bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel use of cryogenic cooling conditions in improving the machining performance of Al 8011/nano-SiC composites
Authors: Ross Nimel Sworna , Manasea Selvin Belsam Jeba Ananth , Nagarajan Srinivasan , Mashinini Peter Madindwa , Dharmalingam Satish Kumar , Savio Akash Paul , Gupta Munish Kumar , Korkmaz Mehmet Erdi 
Published: October 2023

AbstractThe inclusion of nanoparticles makes the composite not only stronger but also lighter and highly resistant towards wear among many other positive attributes. However, the high hardness and abrasive characteristics of the composites make machining a formidable task. Hence to surmount these challenges, various coolant conditions have been entailed like dry machining, flood cooling, minimum quantity lubrication (MQL), and cryogenic (cryo) CO2 cooling. This investigation encompasses the influence of diverse coolant techniques during the machining of as casted aluminium with nano silicon carbide (Al/n-SiC) composite. This study further incites the analysis of the machining temperature, surface characteristics, flank wear, and chip morphology under each coolant techniques. The outcomes of this investigation furnish a comprehensive understanding of the impact of distinct coolant environments on the machining performance of Al/n-SiC composite. The cutting temperature under cryo-CO2 was found to be lowered by 41–47%, 15–21%, and 8–12% when compared to the usage of dry, flood, and MQL, respectively. The study unveils that cryo-CO2 cooling developed the lowest machining temperature, followed by MQL, flood cooling, and dry machining. Furthermore, cryo-CO2 cooling and MQL exhibited the best outcome in terms of flank wear and surface characteristics. The verdicts of this investigation suggest the use of cryo-CO2 cooling and MQL makes eloquent improvement in the machining performances of Al/n-SiC composites.
Impact of body mass index in patients with tricuspid regurgitation after transcatheter edge-to-edge repair
Authors: Vogelhuber Johanna , Tenaka Tetsu , Sudo Mitsumasa , Sugiura Atsushi , Öztürk Can , Kavsur Refik , Donner Anika , Nickenig Georg , Zimmer Sebastian , Weber Marcel , Wilde Nihal 
Published: October 2023

Abstract
Background
Obesity and underweight represent classical risk factors for outcome in patients treated for cardiovascular disease. This study describes the impact of different body mass index (BMI) categories on 1-year clinical outcome in patients with tricuspid regurgitation (TR) undergoing transcatheter-edge-to-edge repair (TEER).

Methods
We analyzed 211 consecutive patients (age 78.3 ± 7.2 years, 55.5% female, median EuroSCORE II 9.6 ± 6.7) with tricuspid regurgitation undergoing TEER from June 2015 until May 2021. Patients were prospectively enrolled in our single center registry and were retrospectively analyzed. Patients were stratified according to body mass index (BMI) into 4 groups: BMI < 20 kg/m2 (underweight), BMI 20.0 to < 25.0 kg/m2 (normal weight), BMI 25.0 to > 30.0 kg/m2 (overweight) and BMI ≥ 30 kg/m2 (obese).

Results
Kaplan–Meier survival curves demonstrated inferior survival for underweight and obese patients, but comparable outcomes for normal and overweight patients (global log rank test, p < 0.01). Cardiovascular death was significantly higher in underweight patients compared to the other groups (24.1% vs. 7.0% vs. 6.3% vs. 6.4%; p < 0.01). Over all, there were comparable rates of bleeding, stroke and myocardial infarction. Multivariable Cox regression analysis (adjusted for age, gender, coronary artery disease, chronic obstructive pulmonary disease, tricuspid annular plane systolic excursion, left-ventricular ejection fraction) confirmed underweight (HR 3.88; 95% CI 1.64–7.66; p < 0.01) and obesity (HR 3.24; 95% CI 1.37–9.16; p < 0.01) as independent risk factors for 1-year all-cause mortality.

Conclusions
Compared to normal weight and overweight patients, obesity and underweight patients undergoing TEER display significant higher 1-year all-cause mortality.

Graphical abstract
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Authors: Kaludercic Nina , Arusei Ruth Jepchirchir , Di Lisa Fabio 
Published: October 2023

AbstractNumerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen species (ROS). However, the individual contribution of different mitochondrial processes independently of bioenergetics remains elusive and clinical treatments unavailable. A notable exception to this complexity is found in the case of monoamine oxidases (MAOs). Unlike other ROS-producing enzymes, especially within mitochondria, MAOs possess a distinct combination of defined molecular structure, substrate specificity, and clinically accessible inhibitors. Another significant aspect of MAO activity is the simultaneous generation of hydrogen peroxide alongside highly reactive aldehydes and ammonia. These three products synergistically impair mitochondrial function at various levels, ultimately jeopardizing cellular metabolic integrity and viability. This pathological condition arises from exacerbated MAO activity, observed in many cardiovascular diseases, thus justifying the exploration of MAO inhibitors as effective cardioprotective strategy. In this context, we not only summarize the deleterious roles of MAOs in cardiac pathologies and the positive effects resulting from genetic or pharmacological MAO inhibition, but also discuss recent findings that expand our understanding on the role of MAO in gene expression and cardiac development.
Silica-based microencapsulation used in topical dermatologic applications
Authors: Green Lawrence J. , Bhatia Neal D. , Toledano Ofer , Erlich Maya , Spizuoco Amy , Goodyear Benjamin C. , York Jean Philippe , Jakus Jeannette 
Published: October 2023

AbstractMicroencapsulation has received extensive attention because of its various applications. Since its inception in the 1940s, this technology has been used across several areas, including the chemical, food, and pharmaceutical industries. Over-the-counter skin products often contain ingredients that readily and unevenly degrade upon contact with the skin. Enclosing these substances within a silica shell can enhance their stability and better regulate their delivery onto and into the skin. Silica microencapsulation uses silica as the matrix material into which ingredients can be embedded to form microcapsules. The FDA recognizes amorphous silica as a safe inorganic excipient and recently approved two new topical therapies for the treatment of rosacea and acne. The first approved formulation uses a novel silica-based controlled vehicle delivery technology to improve the stability of two active ingredients that are normally not able to be used in the same formulation due to potential instability and drug degradation. The formulation contains 3.0% benzoyl peroxide (BPO) and 0.1% tretinoin topical cream to treat acne vulgaris in adults and pediatric patients. The second formulation contains silica microencapsulated 5.0% BPO topical cream to treat inflammatory rosacea lesions in adults. Both formulations use the same amorphous silica sol–gel microencapsulation technology to improve formulation stability and skin compatibility parameters.
Effects of intermittent pneumatic compression on the recovery of cardiovascular parameters after repeated sprint exercise
Authors: Artés Arnau , Ferrer-Ramos Pau , Javierre Casimiro , Viscor Ginés , García Iker 
Published: October 2023

Abstract
Purpose
Intermittent pneumatic compression (IPC) applies gradual pressure to facilitate lymph and blood flow movement to reduce exercise-induced tissue fluid accumulation and plasma volume loss. This study aimed to evaluate the cardiovascular system response during the recovery with IPC compared with passive recovery (Sham).

Methods
Sixteen volunteers (7 females and 9 males) executed a cycling-based exhausting sprint interval exercise (8 × 20 s all out), followed by a 30-min IPC or Sham condition. Participants performed two trials in a randomised, counterbalanced, and crossover design. Several cardiovascular parameters (blood pressure, heart function, and peripheral vascular resistance) were recorded at baseline (5ʹ), through the recovery protocol (30ʹ), and afterwards (5ʹ).

Results
The use of IPC during the recovery phase led to a faster recovery, stated in relative values to pre-exercise, in mean blood pressure (102.5 ± 19.3% vs. 92.7 ± 12.5%; P < 0.001), and cardiac output (139.8 ± 30.0% vs. 146.2 ± 40.2%; P < 0.05) in comparison to Sham condition. Furthermore, during the IPC-based recovery, there was a slower recovery in cardiac pressure change over time (92.5 ± 25.8% vs. 100.5 ± 48.9%; P < 0.05), and a faster return to pre-exercise values in the peripheral vascular resistance (75.2 ± 25.5% vs. 64.8 ± 17.4%; P < 0.001) compared to Sham.

Conclusion
The application of IPC after high-intensity exercise promotes the recovery of the cardiovascular system, reducing cardiovascular strain. Future investigations should consider the effects on the sympathetic-parasympathetic balance, such as heart rate variability, to assess further bonds between the use of IPC and autonomous control.
Resting-state functional connectivity in an auditory network differs between aspiring professional and amateur musicians and correlates with performance
Authors: Papadaki Eleftheria , Koustakas Theodoros , Werner André , Lindenberger Ulman , Kühn Simone , Wenger Elisabeth 
Published: October 2023

AbstractAuditory experience-dependent plasticity is often studied in the domain of musical expertise. Available evidence suggests that years of musical practice are associated with structural and functional changes in auditory cortex and related brain regions. Resting-state functional magnetic resonance imaging (MRI) can be used to investigate neural correlates of musical training and expertise beyond specific task influences. Here, we compared two groups of musicians with varying expertise: 24 aspiring professional musicians preparing for their entrance exam at Universities of Arts versus 17 amateur musicians without any such aspirations but who also performed music on a regular basis. We used an interval recognition task to define task-relevant brain regions and computed functional connectivity and graph-theoretical measures in this network on separately acquired resting-state data. Aspiring professionals performed significantly better on all behavioral indicators including interval recognition and also showed significantly greater network strength and global efficiency than amateur musicians. Critically, both average network strength and global efficiency were correlated with interval recognition task performance assessed in the scanner, and with an additional measure of interval identification ability. These findings demonstrate that task-informed resting-state fMRI can capture connectivity differences that correspond to expertise-related differences in behavior.
A multiphase-field approach to small strain crystal plasticity accounting for balance equations on singular surfaces
Authors: Prahs Andreas , Schöller Lukas , Schwab Felix K. , Schneider Daniel , Böhlke Thomas , Nestler Britta 
Published: October 2023

AbstractAn implementation of the crystal plasticity theory in the context of the multiphase-field method provides a numerically efficient tracking of evolving grain boundaries, modeled as diffuse interfaces. In literature, several approaches exist for the implementation of the plastic material behavior within the diffuse interface, based on interpolation, homogenization, or the mechanical jump conditions. Among these, only the jump condition approach exhibits an intrinsic relationship to the sharp interface (SI) theory. Therefore, in the work at hand, the implementation of the crystal plasticity theory within the jump condition approach, referred to as phase-specific plastic fields approach (PSPFA), is discussed in detail. The PSPFA is compared to the interpolation approach, referred to as common plastic fields approach (CPFA), using three-dimensional benchmark simulations of a bicrystal set-up. The comparison reveals that the PSPFA and SI coincide convincingly regarding the accumulated plastic slip and the Mises stress. In contrast, a significant deviation of CPFA and SI is observed both quantitatively and qualitatively, not only within the diffuse interface region, but throughout the complete simulation domain. A variation of the interface width illustrates that this observation can be transferred to the normal components of the total strain, even for smaller interface widths. Consequently, a quantitative estimate of the plastic material behavior, which is crucial for the prediction of the dynamic behavior of grain boundaries, is only provided by the PSPFA. The application of the crystal plasticity in the context of PSPFA to more complex microstructures is illustrated with respect to a periodic honeycomb-structure and an octotuple.
Controllability of periodic linear systems, the Poincaré sphere, and quasi-affine systems
Authors: Colonius Fritz , Santana Alexandre , Setti Juliana 
Published: October 2023

AbstractFor periodic linear control systems with bounded control range, an autonomized system is introduced by adding the phase to the state of the system. Here, a unique control set (i.e., a maximal set of approximate controllability) with nonvoid interior exists. It is determined by the spectral subspaces of the homogeneous part which is a periodic linear differential equation. Using the Poincaré sphere, one obtains a compactification of the state space allowing us to describe the behavior “near infinity” of the original control system. Furthermore, an application to quasi-affine systems yields a unique control set with nonvoid interior.
“The song remains the same”: not really! Vocal flexibility in the song of the indris
Authors: Zanoli Anna , Raimondi Teresa , De Gregorio Chiara , Valente Daria , Carugati Filippo , Torti Valeria , Friard Olivier , Miaretsoa Longondraza , Giacoma Cristina , Gamba Marco 
Published: October 2023

AbstractIn studying communicative signals, we can think of flexibility as a necessary correlate of creativity. Flexibility enables animals to find practical solutions and appropriate behaviors in mutable situations. In this study, we aimed to quantify the degree of flexibility in the songs of indris (Indri indri), the only singing lemur, using three different metrics: Jaro Distance, normalized diversity, and entropy. We hypothesized that the degree and the co-variation of the flexibility of indris singing together would vary according to their status and sex. We found that dominant females were more flexible than dominant males when concatenating elements into strings (element concatenation). The number of different elements in a song contribution normalized by the contribution length (contribution diversity) of dominant individuals positively co-varied for seven duetting pairs. Non-dominant individuals were more variable in element concatenation than dominant individuals, and they were more diverse in phrase type than dominant females. Independently from sex and status, individual contributions did not differ in entropy (a measure of the predictability of contributions). These results corroborate previous findings regarding the dimorphism by sex and by status of individual contributions to songs. Thus, they shed light on the presence and expression of flexibility in the behavior of a non-human primate species. Indeed, they potentially show an effect of social features in shaping vocal flexibility, which underlies many communication systems, including human language. We speculate that this degree of flexibility may account for creativity.
Compound hazards of climate change, forestry, and other encroachments on winter pasturelands: a storyline approach in a forest reindeer herding community in Northern Sweden
Authors: Harnesk David , Pascual Didac , Olsson Lennart 
Published: October 2023

AbstractThe impacts of climate change on rural cultures and livelihoods depend on how the resulting complex biophysical processes may transform people’s land use practices. We argue that research can incorporate local concerns of compound hazards through deterministic rather than probabilistic approaches to better understand the multiple causations involved in such climate change impacts. We apply mixed methods within a storyline approach to examine how a forest reindeer herding community in Northern Sweden copes with and experiences basal ice formation on their winter pasturelands under the influence of climatic and environmental change. Our results show that the detrimental impact of basal ice formation on the availability of winter forage for reindeer is amplified by the directional effects of climate change and encroachments, especially particular forestry practices and their surrounding infrastructure. On the one hand, we show that policy action can address local concerns through ecological interventions that improve the amount and distribution of ground and pendulous lichens at the pastoral landscape scale. On the other hand, we show that policy inaction can threaten the community’s desired experience of human-animal relations in their landscape, which was inextricably connected to ecological conditions for natural pasture-based reindeer pastoralism.
Associations Between Sexual Behavior Stigma and HIV Risk Behaviors, Testing, Treatment, and Infection Among Men Who have Sex with Men in Ukraine
Authors: Alvey Ben , Stone Jack , Salyuk Tetyana , Barzilay Ezra J. , Doan Ivan , Vickerman Peter , Trickey Adam 
Published: October 2023

AbstractStigma toward same-sex behaviors may be a structural driver of HIV epidemics among men who have sex with men (MSM) in Eastern Europe and has been linked to adverse HIV-outcomes elsewhere. We explored associations between sexual behavior stigma with HIV risk behaviors, testing, treatment, and infection. From November 2017 to February 2018, MSM across 27 Ukrainian cities were recruited to cross-sectional surveys using respondent driven sampling. Eligible participants were cisgender males aged ≥ 14 years residing in participating cities that reported ≥ 1 sexual contact with another man in the prior 6 months. Participants self-reported experience of stigma (ever) and various HIV-outcomes and were tested for HIV antibodies. Regression models were used to explore associations between three sexual behavior stigma variables with demographic and HIV-related variables. Of 5812 recruited cisgender MSM, 5544 (95.4%) were included. 1663 (30.0%) MSM reported having experienced stigma due to being MSM from family and friends, 698 (12.6%) reported anticipated healthcare stigma, and 1805 (32.6%) reported general public/social stigma due to being MSM (enacted). All forms of stigma were associated with heightened HIV risk behaviors; those experiencing stigma (vs not) had more anal sex partners in the prior month and were less likely to have used condoms during their last anal intercourse. Stigma was not associated with HIV infection, testing, or treatment variables. A sizeable proportion of Ukrainian MSM reported ever experiencing stigma due to being MSM. MSM that had experienced stigma had higher odds of HIV sexual risk behaviors. Further study using longitudinal designs is required to determine causality.
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
Authors: Kubatka Peter , Koklesova Lenka , Mazurakova Alena , Brockmueller Aranka , Büsselberg Dietrich , Kello Martin , Shakibaei Mehdi 
Published: October 2023

AbstractCancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the multiple cancer defense mechanisms associated with therapy resistance and therapy evasion. Cancer resistance represents one of the significant obstacles in the clinical management of cancer. Some reversal chemosensitizing agents have been developed to resolve this serious clinical problem, but they have not yet been proven applicable in oncological practice. Activated nuclear factor kappa B (NF-κB) is a frequently observed biomarker in chemoresistant breast cancer (BC). Therefore, it denotes an attractive cellular target to mitigate cancer resistance. We summarize that flavonoids represent an essential class of phytochemicals that act as significant regulators of NF-κB signaling and negatively affect the fundamental cellular processes contributing to acquired cell plasticity and drug resistance. In this regard, flavokawain A, icariin, alpinetin, genistein, wogonin, apigenin, oroxylin A, xanthohumol, EGCG, hesperidin, naringenin, orientin, luteolin, delphinidin, fisetin, norwogonin, curcumin, cardamonin, methyl gallate and catechin-3-O-gallate, ampelopsin, puerarin, hyperoside, baicalein, paratocarpin E, and kaempferol and also synthetic flavonoids such as LFG-500 and 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone have been reported to specifically interfere with the NF-κB pathway with complex signaling consequences in BC cells and could be potentially crucial in re-sensitizing unresponsive BC cases. The targeting NF-κB by above-mentioned flavonoids includes the modification of tumor microenvironment and epithelial-mesenchymal transition, growth factor receptor regulations, and modulations of specific pathways such as PI3K/AKT, MAP kinase/ERK, and Janus kinase/signal transduction in BC cells. Besides that, NF-κB signaling in BC cells modulated by flavonoids has also involved the regulation of ATP-binding cassette transporters, apoptosis, autophagy, cell cycle, and changes in the activity of cancer stem cells, oncogenes, or controlling of gene repair. The evaluation of conventional therapies in combination with plasticity-regulating/sensitizing agents offers new opportunities to make significant progress towards a complete cure for cancer.
Graphical abstract
Foreign Supply Shocks and the Structure of Trade in a Small Open Economy
Authors: Böschemeier Jonas , Mau Karsten 
Published: October 2023

AbstractWe evaluate how imports of a small open economy adjusted to foreign supply disruptions in the first year of the COVID-19 pandemic. Exploiting information on the timing, stringency, and persistence of coronavirus containment measures, we estimate their impact on the value and composition of imports. About half of the total contraction is attributed to foreign supply-sided disruptions. Contractions were more pronounced in concentrated import markets, but more severe contractions were prevented by trade partner substitution. We document systematic reallocation of market shares towards countries with large supply capacity and low COVID-19 incidence rates in the second half of 2020.