bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Topological Indices for Analyzing Chemical and Metallic Frameworks: A Focus on Connection Numbers
Authors: . Dilawaiz , Umer Muhammad , Iqbal Hifza , Olejnik Pawel 
Published: October 2023

Abstract
In the study of molecular atoms, numerous topological indices possess useful properties. This paper examines different types of topological indices, including the first Zagreb connection index, second Zagreb connection index, forgotten index, redefined Zagreb index, general randic index, and symmetric division degree index, to analyze the chemical and metallic structure. Furthermore, we explore the Zagreb Connection indices of Concealed non-kekulean benzenoid hydrocarbons (CNBH) and the Face Centered Cubic Lattice (FCC). The results are presented through mathematical quantities and visualized using 3D plots.
Alpha1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in the human vas deferens
Authors: Britto-Júnior José , Guimarães Renan Arthur Bosio , Oliveira Denis Lima , Lima Antonio Tiago , Junior Gilberto Quirino , Stocco Gabriel Augusto Oliveira , Uramoto Edson Hiroshi Salgado , Fregonesi Adriano , Antunes Edson , De Nucci Gilberto 
Published: October 2023

Abstract
Background: 6-Nitrodopamine (6-ND) is released from human vas deferens and plays a modulatory role in the male ejaculation. Therapeutical use of α1-adrenoceptor antagonists is associated with ejaculatory abnormalities.
Objectives: To evaluate the effect of α1-adrenoceptor antagonists on the contractions induced by 6-ND, dopamine, noradrenaline, and adrenaline in the human epididymal vas deferens (HEVD).
Methods: HEVD strips were suspended in glass chambers containing heated and oxygenated Krebs-Henseleit’s solution. Cumulative concentration-response curves to catecholamines (10 nM-300 mM) were constructed in HEVD strips pre-incubated (30 min) with doxazosin (0.1-1nM), tamsulosin (1-10 nM), prazosin (10-100 nM) and/or silodosin (0.1-10 nM). The effects of these α1-adrenoceptor antagonists were also evaluated in the electric-field stimulation (EFS, 2-32 Hz)-induced contractions.
Results: Doxazosin (0.1 nM) caused significant reductions in 6-ND-induced HEVD contractions without affecting the contractions induced by dopamine, noradrenaline, and adrenaline. Similar results were observed with tamsulosin (1 nM) and prazosin (10 nM). At these concentrations, these α1-adrenoceptor antagonists largely reduced the EFS-induced contractions. Silodosin (1 nM) caused concentration-dependent rightward shifts of the concentration-response curves to 6-ND but had no effect on the contractions induced by dopamine and adrenaline. Silodosin (0.1 nM) only inhibited the contractions induced by noradrenaline. Silodosin at 1 nM, but not at 0.1 nM, caused significant reductions in the EFS-induced contractions.
Discussion and conclusion: The results indicate that 6-ND plays a major role in the human vas deferens contractility and doxazosin, tamsulosin, prazosin and silodosin cause ejaculation disorders in man by blocking the 6-ND receptor rather than α1-adrenoceptors.
Factors affecting delays in seeking treatment among malaria patients in the post-elimination phase in China
Authors: Jia Lianyu , Chen Xiaoyu , Feng Zhanchun , Tang Shangfeng , Feng Da 
Published: October 2023

Abstract
Background
Delays in malaria treatment can not only lead to severe and even life-threatening complications, but can also be a source of malaria re-transmission, putting more people at risk of infection. This study aimed to investigate the influencing factors influencing treatment delays among malaria patients and their health-seeking behavior.
Methods
The medical records of 494 patients diagnosed with malaria from 6 different malaria-endemic provinces in China were analyzed. A bivariate and multivariable regression model was used to investigate the association between delays in seeking treatment and various factors. A Sankey diagram was used to visualize the trajectories of malaria patients seeking medical care. Total treatment delays were categorized as patient delays and docotor delays.
Results
The incidence of total delays in seeking malaria treatment was 81.6%, of which 28.4% were delayed by patients alone and 34.8% by doctors. The median time of patient delays was 1 day (IQR, 0-20 days), and the median time of doctor delays was 2 days (IQR, 0-90 days). After being subjected to multiple logistic regression analysis, the factor significantly associated with patient delays was living in central China (OR=0.43, 95% CI: 0.24-0.78). The factors significantly associated with doctor delays were: age between 30 to 49 years old (OR=0.43, 95% CI: 0.23-0.81), being sigle/divorce/separated (OR = 0.48, 95% CI: 0.24-0.95), mixed infections (OR = 2.04, 95% CI: 1.02-4.08), first visiting a county-level health institution (OR = 0.25, 95% CI: 0.14-0.45), first visiting a prefectural health institution (OR = 0.06, 95% CI: 0.03-0.12), first visiting a provincial health institution (OR = 0.05, 95%CI: 0.02-0.12), and having periodic symptoms (OR=1.71, 95% CI: 1.00-2.92). Furthermore, higher financial burden and complications were found to be associated with patient delays. Doctor delays, in addition to incurring these two consequences, were associated with longer hospital stays.
Conclusion
There was a substantial delay in access to health care for malaria patients before China was certified malaria free. Region, marital status, periodic symptoms and the level of health institutions were factors contributing to delays in treatment-seeking among malaria patients.
Pollen microbiomes of solitary bees (Osmia rufa L. syn. O. bicornis) from seed orchards
Authors: Kęsy Mateusz , Cłapa Tomasz , Narożna Dorota 
Published: October 2023

Abstract
The red mason (Osmia rufa L. syn. O. bicornis) is a solitary bee that is commonly used for pollination of fruit crops. Given the declining numbers of pollinators in various environments, the mason bee has not only become an effective insect as an additional pollinator, but sometimes it becomes the main species that is used to increase the yield of crops. Due to easy rearing and not showing aggressiveness towards people. The individual features of the mason bee have made the interest in this species constantly growing. Currently, the wild bees is more important for the forestry and production the seeds. So far, only the honeybee (Apis mellifera mellifera) has been successfully used to work in forest areas, especially with the flowers of Tilia cordata Mill. The rearing of mason bee (Osmia rufa L.) in forest areas is new. The paper presents information on the microbiome of pollen collected from the brood chambers of the solitary bee Osmia rufa L. in various forest biotopes: Tilia cordata Mill, Quercus petraea Liebl. and Prunus avium L. The presence of five groups of bacteria was found in all analyzed pollens were rich in α-Proteabacteria, Actinobacteria and Firmicutes, while β-Proteobacteria and Bacteroides were present in a lower level. Despite the presence of bacteria in the pollen, no increased bee mortality was observed in any of the bee nests of forest biotopes. It was found that the forest environment does not pose a threat to the development of Osmia rufa L. bees.
How environmental, geographic, socio-demographic, and epidemiological indicators influence malaria prevalence
Authors: Villena Oswaldo C. , Arab Ali , Lippi Catherine A. , Ryan Sadie J. , Johnson Leah R. 
Published: October 2023

Abstract
Background: The interactions of environmental, geographic, socio-demographic, and epidemiological factors in shaping mosquito-borne disease transmission dynamics are complex and changeable, influencing the abundance and distribution of vectors and the pathogens they transmit. In this study, 27 years of prevalence data (1990-2017) were used to examine the effects of environmental (temperature, precipitation, normalized difference vegetation index, isothermality), geographic (elevation), socio-economic (population density, gross domestic product per capita, human development index), and epidemiological (basic reproductive number) factors on Plasmodium falciparum and Plasmodium vivax malaria in Africa and Asia.
Methods: Monthly long-term, open-source data for each factor were compiled and analyzed using two approaches: generalized linear models (GLM) and classification and regression trees (CART). Both approaches were used to identify associations between environmental, geographic, socioeconomic, and epidemiological factors with malaria prevalence (the proportion of people infected with malaria in a given time period). Plasmodium. falciparum and P. vivax malaria prevalence were examined in Asia, and only P. falciparum in Africa. Model fit was assessed, estimating the accuracy, precision, recall, and the f1-score of the models.
Results: Both CART and GLMs provided robust predictions of malaria prevalence, but the CART model exhibited slightly better accuracy and precision. An optimum temperature for malaria prevalence around 25 ◦C for P. falciparum prevalence was observed in Africa but not for P. falciparum and P. vivax in Asia which was below 25 ◦C. The decline of malaria prevalence from 2000 to 2012 was well capture by the models as well as the resurgence of P. falciparum prevalence in Africa and Asia. Precipitation showed a unimodal response to malaria prevalence with a positive effect up to a point of 200 - 400 mm of rainfall; then a negative effect was observed as precipitation increased. Higher predicted malaria prevalence in regions with lower GDPPC and lower HDI and a positive correlation with the basic reproductive number.
Conclusion: This study showed that there was a combination of environmental, geographic, socioeconomic, and epidemiological indicators driving malaria prevalence. Identifying these, and describing their associations provides key information to inform planning strategies and interventions to reduce malaria burden in Africa and Asia.
WITHDRAWN: A Multi-Graph Neural Networks Based on Dynamic Spatio-temporal for Urban Traffic Flows Prediction
Authors: Ali Ahmad , Zakarya Muhammad , Qazani Mohammad Reza Chalak , Khan Ayaz Ali , Ahmed Aftab , Al-Bahri Mahmood 
Published: October 2023

Abstract

The primary function of an intelligent transportation system (ITS) is traffic prediction. Perfect traffic forecasting can largely enhance the use of public incomes. It is, however, difficult due to the dynamic and complex nature of spatial-temporal dependencies. Largely, the existing methods rely on static adjacency matrices, which do not reflect the simultaneous collaboration of several spatial-temporal correlations and therefore limit the accuracy and correctness of forecasting. In order to address this issue, and to illustrate the dynamic interplay of various spatial-temporal correlations in the traffic flows network, this research suggests a unified simultaneous Multi Fusion Graph Network (DMFGNet) model. The dynamic graph fusion in the proposed DMFGNet model is intended to extract dynamic spatial-temporal dependencies among different areas. Meanwhile, the model Spatial-Temporal attention Unit (DSTAU) is proposed to regulate the weights of aggregation of various neighbours. It may carefully aggregate spatiotemporal properties from various neighbours. To display the usefulness and practicality of the suggested model, extensive evaluation and experiments were conducted on two large scale real-world traffic flow data-sets. The experimental findings validate the benefit of the advised model over prevailing state-of-the-art baseline techniques. Furthermore, the outcomes show that the suggested approach is efficient and practical.
Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial
Authors: Menz Hylton , Lim Polly Q. X. , Hurn Sheree E. , Mickle Karen J. , Buldt Andrew K. , Cotchett Matthew P. , Roddy Edward , Wluka Anita E. , Erbas Bircan , Batra Mehak , Munteanu Shannon E. 
Published: October 2023

Abstract

Background Hallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aimed to determine the feasibility of conducting a parallel group randomised trial to evaluate the effectiveness of a nonsurgical intervention for reducing pain associated with hallux valgus. Methods Twenty-eight community-dwelling women with painful hallux valgus were randomised to receive either a multifaceted, nonsurgical intervention (footwear, foot orthoses, foot exercises, advice, and self-management) or usual care (advice and self-management alone). Outcome measures were obtained at baseline, 4, 8 and 12 weeks. The primary outcome was feasibility, evaluated according to demand (recruitment rate and conversion rate), acceptability, adherence, adverse events, and retention rate. Limited efficacy testing was conducted on secondary outcome measures including foot pain, foot muscle strength, general health-related quality of life, use of cointerventions, and participants’ perception of overall treatment effect. Results Between July 8, 2021, and April 22, 2022, we recruited and tested 28 participants (aged 44 to 80 years, mean 60.7, standard deviation 10.7). This period encompassed two COVID-related stay-at-home orders (July 16 to July 27, and August 5 to October 21, 2021). The predetermined feasibility thresholds were met for retention rate, foot pain, mental health-related quality of life, and use of cointerventions, partly met for acceptability, adverse events, and muscle strength, and not met for demand (recruitment rate or conversion rate), adherence, physical health-related quality of life and perception of overall treatment effect. Conclusion In its current form, a randomised trial of footwear, foot orthoses, foot exercises, advice and self-management for relieving pain associated with hallux valgus is not feasible, particularly due to the low adherence with the intervention. However, it is difficult to determine whether the trial would be feasible under different circumstances, particularly due to COVID-19 stay-at-home orders. Future trials will need to consider improving the aesthetics of the footwear and making the exercise program less burdensome. Trial registration Australian and New Zealand Clinical Trial Registry (ACTRN12621000645853).
Toxicity effects of zinc supply on growth revealed by physiological and transcriptomic evidences in sweet potato (Ipomoea batatas(L.) Lam)
Authors: Meng Yusha , Xiang Chao , Huo Jinxi , Shen Shengfa , Tang Yong , Wu Liehong 
Published: October 2023

Abstract
Zinc toxicity affects crop productivity and threatens food security and human health worldwide. Unfortunately, accumulation patterns of zinc and the harm of excessive zinc on sweet potato have not been well explored. In present research, two genotypes sweet potato varieties with different accumulation patterns of zinc were selected for analyzing the effects of excessive zinc on sweet potato via hydroponic and field cultivation experiments. The results indicated that transfer coefficient was closely related to zinc concentration in storage root of sweet potato. Excessive zinc inhibited the growth of sweet potato plants by causing imbalanced mineral concentration, destroying the cellular structure and reducing photosynthesis. Further, a total of 17,945 differentially expressed genes were identified in in the two genotypes under zinc stress by transcriptomic analysis. And differentially expressed genes involved in absorption and transport of zinc, defense network and transcription factors played important roles in responding to zinc stress. In conclusion, this study provides a reference for the selection of sweet potato varieties in zinc contaminated soil and lays a foundation of investigating the tolerance of sweet potato for excessive zinc, which is meaningful for environmental safety and human health.
Bayesian-frequentist hybrid inference framework for single cell RNA-seq analyses
Authors: Han Gang , Yan Dongyan , Sun Zhe , Fang Jiyuan , Chang Xinyue , Wilson Lucas , Liu Yushi 
Published: October 2023

Abstract

Background: Single cell RNA sequencing technology (scRNA-seq) has been proven useful in understanding cell-specific disease mechanisms. However, identifying genes of interest remains a key challenge. Pseudo-bulk methods that pool scRNA-seq counts in the same biological replicates have been commonly used to identify differentially expressed genes. However, such methods may lack power due to the limited sample size of scRNA-seq datasets, which can be prohibitively expensive.
Results: Motivated by this, we proposed to use the Bayesian-frequentist hybrid (BFH) framework to increase the power.
Conclusion: In our idiopathic pulmonary fibrosis (IPF) case study, we demonstrated that with a proper informative prior, the BFH approach identified more genes of interest. Furthermore, these genes were reasonable based on the current knowledge of IPF. Thus, the BFH offers a unique and flexible framework for future scRNA-seq analyses.
Comparison of Plasmodium Vivax Infections in Duffy Negatives From Community and Health Center Collections in Ethiopia
Authors: Bradley Lauren , Yewhalaw Delenasaw , Hemming-Schroeder Elizabeth , Jeang Brook , Lee Ming-Chieh , Zemene Endalew , Degefa Teshome , Lo Eugenia , King Christopher , Kazura James , Yan Guiyun 
Published: October 2023

Abstract
Background
Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 4.2 million annual cases and 61% of the population living in areas at risk of malaria transmission. Throughout the country Plasmodium vivax and P. falciparum are co-endemic, and Duffy expression is highly heterogeneous. The public health significance of Duffy negativity in relation to P. vivax malaria in Ethiopia, however, remains unclear.
Methods
A total of 9,580 and 4,667 subjects from community and health facilities from a malaria endemic site and an epidemic-prone site in western Ethiopia were enrolled and examined for P. vivax infection and Duffy expression. Association between Duffy expression, P. vivax and P. falciparum infections were examined for samples collected from asymptomatic community volunteers and symptomatic subjects from health centers.
Results
Among the community-based cross-sectional samples, infection rate of P. vivax among the Duffy positives was 2–22 fold higher than among the Duffy negatives. Parasite positivity rate was 10–50 fold higher in Duffy positive than Duffy negatives among samples collected from the health center settings and mixed P. vivax and P. falciparum infections were significantly more common than P. vivax mono infections among Duffy negative individuals. P. vivax parasitemia measured by 18sRNA parasite gene copy number was similar between Duffy positives and Duffy negatives.
Conclusions
Duffy negativity does not offer complete protection against infection by P. vivax, and cases of P. vivax in Duffy negatives are widespread in Ethiopia, being found in asymptomatic volunteers from communities and in febrile patients from health centers. These findings offer evidence for consideration when developing control and intervention strategies in areas of endemic P. vivax and Duffy heterogeneity.
Axial intensity of Bessel higher-order cosh-Gaussian beam propagating in a turbulent atmosphere
Authors: Dalil-Essakali L. , Nossir N. , Belafhal A. 
Published: October 2023

Abstract
In the present paper, the effects of the turbulent atmosphere on the propagation properties of Bessel higher-order cosh-Gaussian (BHChG) beam are investigated. Based on the Rytov approximation and the extended Huygens-Fresnel integral diffraction, analytical expression of the axial intensity for BHChG beam is evaluated and the results of some laser beams are deduced as particular cases from our research. Some graphical representations have been carried out to study the influence of the incident beam parameters and the atmospheric turbulence on the considered beam. The obtained results can be useful for atmospheric optics applications in free-space optical communications.
Pruned Broad Learning System Based on Sparse Ridge Fusion
Authors: Chu Fei , Lu Xinyu , Su Jiaming , Liang Tao , Chen C. L. Philip , Wang Xuesong 
Published: October 2023

Abstract

Broad learning system is an emerging method, which has achieved outstanding performance in regression and classification problems. This paper proposes a novel algorithm called Pruned Broad Learning System (PBLS) to reduce model size and improve model interpretability. The proposed PBLS introduces the sparse ridge fusion penalty into BLS, which combines the \({L_1} - norm\) regularizer and second order difference penalty together. The \({L_1} - norm\) regularizer is used to sparse the model by making insignificant output weights toward zero, while second order difference penalty is used to smooth output weights by penalizing the roughness of the model. Then, the unimportant nodes are pruned from the model. The remaining useful nodes are divided in the form of block structure, and their output weights change slowly and smoothly in their respective block structure. The experiments on several commonly used regression data sets are carried out to verify the feasibility of the proposed pruned BLS. The experiment results indicate that pruned BLS can reduce model complexity without loss of prediction accuracy and improve the model interpretability.
Reporting of Mammary Tumours in Indigenously developed Spontaneous NIN/Sprague Dawley Mutant (Nude) Rat Strain
Authors: Vani Motha Satya , Patil Pradeep Bhatu , V. Surekha M. , B. Tulja , Naik Ravinder , M. Srinivas , Qadri SSYH 
Published: October 2023

Abstract

Background:
Breast cancer has been linked with many causes including nutrition. However spontaneous mammary tumour rodent model will unlock many such mechanisms. The past five decades, the ICMR-NIN animal facility has diligently maintained a colony of Sprague Dawley rats. Around a decade ago, a spontaneous mutation emerged within this colony. This mutation, rather than being discarded, was intentionally nurtured to comprehend its phenotype and its potential utility as a research model. This manuscript is dedicated to presenting significant insights into its immunological and histological characteristics.
Materials and Methods:
Selective breeding of nude rats (SD/NINhr−/− animals) was carried out by maintaining and crossing them with both their heterozygous phenotype (SD/NINhr+/−) and homozygous phenotype (SD/NINhr−/−). Throughout their entire life cycles, these animals were closely monitored for any development of abnormalities or distinctive traits. The spontaneous development of tumours was recorded under close observation of 24 animals to detect the extent of tumours. Apart from routine body composition, animals were evaluated for their serum biochemistry and CD 4/8 profile.
Results and Discussion:
No significant alterations were observed in the vital organs when compared to the heterozygous animals. Nevertheless, both the homozygous (nude) animals and the heterozygous rats exhibited the spontaneous development of fibroadenomas in the mammary glands during the adult stage, as opposed to the parent colony of NIN/SD rat. Interestingly, the biochemical and T/B cell profiles displayed no correlation with the presence of these tumours. The tumour presented histological pattern similar to mammary tumour in human.
Conclusion:
This unique hairless SD rat model has the capacity to be a suitable choice for research focused on cancer, particularly in the area of mammary tumours. It possesses an immunocompetent nature, mirroring real-life human scenarios, and it has been developed locally, adding to its distinct advantages.