bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local‐ and network‐scale influence of peatlands on boreal catchment response to rainfall events
Authors: Karimi Shirin , Leach Jason , Karlsen Reinert Huseby , Seibert Jan , Bishop Kevin , Laudon Hjalmar 
Published: September 2023

AbstractBoreal catchments are composed of different land covers, such as forests, peatlands and lakes, which differ in their runoff response to rainfall events. Understanding the individual and combined responses to rainfall events of these different land cover types is crucial for predicting potential impacts of future climate conditions on boreal water cycling. A common assumption is that peatlands attenuate peak flows, which is used as a motivation to restore drained boreal wetlands. However, it remains unclear how and to what extent peatlands can affect peak flow response. Only a few previous studies have looked at the hydrologic dynamics of peatlands in response to specific rainfall events across a wide range of nested sub‐catchments with varying peatland cover. In this study, we use nine years of hourly hydrometric data from 14 catchments within the Krycklan Catchment Study in northern Sweden to examine how peatlands contribute to flood attenuation at both local and stream network scales. Our analysis at the local scale demonstrated that during large events with low antecedent wetness conditions, peatland‐dominated catchment exhibited more muted responses compared to the similar‐sized forest‐dominated catchment. However, during events with high antecedent wetness conditions, the peatland‐dominated catchment exhibited flood magnitudes similar to the forest‐dominated catchment, although the elevated flow condition at the peatland‐dominated catchment persisted for longer periods. Finally, our analysis revealed no significant influence of peatlands on the attenuation or amplification of floods at the stream network scale.
The uterine tourniquet, a simple maneuver that may facilitate surgical management of postpartum hemorrhage
Authors: Nieto‐Calvache Albaro José , Barona Juan Sebastián , Burgos‐Luna Juan Manuel , Muñoz‐Córdoba Laura , Sarria‐Ortiz Daniela , Galindo‐Velasco Valentina , Meade Triviño Paulo , Mondragón Karen , Messa‐Byron Adriana 
Published: September 2023

SynopsisThe uterine tourniquet is a temporary intervention that facilitates the application of other procedures for definitive control of postpartum hemorrhage.
Quality testing of mifepristone and misoprostol in 11 countries
Authors: Bower Jason , Chinery Lester , Fleurent Alessandra , Gülmezoglu A. Metin , Im‐Amornphong Wallada , Kilfedder Catherine , Procter Petra , Tomazzini Alessandra 
Published: September 2023

AbstractObjectivePrevious studies have demonstrated quality concerns with misoprostol. Mifepristone, however, has not been extensively assessed for quality. Between 2020 and 2021, Concept Foundation and the International Planned Parenthood Federation conducted a study to determine the quality of these medical abortion drugs in low‐ and middle‐income countries (LMIC).MethodsThe collection of batch samples of misoprostol and mifepristone was carried out by trained sampling agents in selected LMIC. Single drug packs and combipacks were sampled. A World Health Organization prequalified laboratory conducted testing method verifications and subsequent sample analysis. Tests included identification, assay, related substances, and content uniformity for misoprostol, and identification, assay, related substances, and dissolution for mifepristone.ResultsSamples were collected from Burkina Faso, Cambodia, Democratic Republic of Congo, India, Kyrgyzstan, Moldova, Nepal, Nigeria, Pakistan, Uganda and Vietnam. Sixty‐four pooled batch samples were tested, consisting of 31 combipacks, 26 misoprostol‐only and seven mifepristone‐only products. Overall, 54.7% of samples were non‐compliant with one or more of the specifications, representing 51.6% of combipack products, 57.1% of misoprostol tablets analyzed and 23.7% of mifepristone tablets. One falsified misoprostol‐only product was found.ConclusionThe present study confirms that a significant problem still exists in relation to the quality of medical abortion drugs in LMIC. For misoprostol, our findings suggest that historical concerns around primary packaging may have been largely resolved but that manufacturing processes for both finished product and active pharmaceutical ingredient need to be improved. The present study also provides evidence of mifepristone quality issues.
Outcomes of a novel modified total colpocleisis for advanced pelvic organ prolapse in elderly women and its efficacy on lower urinary tract symptoms
Authors: Wang Qi , Lin Hongbiao , Wu Nengxiu , Li Ying , Zhao Rong , Xu Ying , Lin Chaoqin 
Published: September 2023

AbstractObjectivesTo evaluate the effectiveness of modified total colpocleisis for advanced pelvic organ prolapse (POP) in elderly women and to assess the improvement in lower urinary tract symptoms (LUTS) of the patients.MethodsAn observational cohort study was conducted, including 105 POP patients who underwent modified total colpocleisis between April 2020 and December 2022. The study analyzed the patients' demographic characteristics, perioperative outcomes, and follow‐up outcomes, including complications, remission of LUTS, satisfaction rates, and regret rates. Confirming the safety, durability, and patient satisfaction of modified total colpocleisis.ResultsMost patients (95/105, 90.5%) had more than one comorbidity. Eighty‐six (81.9%) had a concomitant hysterectomy, the average operative time was 112.78 ± 34.92 min, with a median estimated bleeding of 50 mL (10–300 mL). Perioperative changes in hemoglobin and hematocrit were 11.64 ± 10.03 g/L and 3.87% ± 3.05%, respectively. Urinary retention was the most common complication (10/105, 9.5%). With a median follow up of 16 months (3–35 months), 101 patients (96.2%) reported satisfaction with the results of the procedure, with none reporting regret. Both subjective and anatomical recurrence rates were quite low (2.9% and 5.7%, respectively). Twenty‐three (21.9%) had de novo urinary incontinence, and the remaining LUTS such as frequent, urgent, hesitation, and difficulty emptying were significantly improved (P < 0.05).ConclusionModified total colpocleisis is an effective treatment option for elderly women with severe POP. This procedure can significantly improve several LUTS, and most de novo incontinence is mild and has a limited impact on patients' quality of life.
Necrostatin‐1 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes
Authors: Smink Alexandra M. , Medina Juan D. , de Haan Bart J. , García Andrés J. , de Vos Paul 
Published: September 2023

AbstractImmunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in the absence of immunosuppression but graft survival time is still limited. This limited graft survival is caused by a combination of tissue responses to the encapsulating biomaterial and islets. A significant loss of islet cells occurs in the immediate period after transplantation and is caused by a high susceptibility of islet cells to inflammatory stress during this period. Here we investigated whether necrostatin‐1 (Nec‐1), a necroptosis inhibitor, can reduce the loss of islet cells under stress in vitro and in vivo. To this end, we developed a Nec‐1 controlled‐release system using poly (D,L‐lactide‐co‐glycolide) (PLGA) nanoparticles (NPs) as the application of Nec‐1 in vivo is limited by low stability and possible side effects. The PLGA NPs stably released Nec‐1 for 6 days in vitro and protected beta cells against hypoxia‐induced cell death in vitro. Treatment with these Nec‐1 NPs at days 0, 6, and 12 post‐islet transplantation in streptozotocin‐diabetic mice confirmed the absence of side effects as graft survival was similar in encapsulated islet grafts in the absence and presence of Nec‐1. However, we found no further prolongation of graft survival of encapsulated grafts which might be explained by the high biocompatibility of the alginate encapsulation system that provoked a very mild tissue response. We expect that the Nec‐1‐releasing NPs could find application to immunoisolation systems that elicit stronger inflammatory responses, such as macrodevices and vasculogenic biomaterials.
Recent advances in glass‐ceramics: Performance and toughening mechanisms in restorative dentistry
Authors: Liu Xiaoming , Yao Xuemin , Zhang Ran , Sun Lingxiang , Zhang Zheyuan , Zhao Yifan , Zhang Tong , Yan Jingyu , Zhang Yanjie , Wu Xiuping , Li Bing 
Published: September 2023

AbstractThe use of glass‐ceramics in the medical field has grown significantly since the 1980s. With excellent aesthetic properties, semi‐translucency, outstanding mechanical properties, corrosion resistance, wear resistance and great biocompatibility and workability glass‐ceramics is one of the most commonly used materials in restorative dentistry and is widely used in veneers, inlays, onlays, all‐ceramic crowns, and implant abutments. This review provides an overview of the research progress of glass‐ceramics in restorative dentistry, focusing on the classification, performance requirements, toughening mechanisms and their association with clinical performance, as well as the manufacturing and fabrication of glass‐ceramics in restorative dentistry. Finally, the developments and prospects of glass‐ceramics in restorative dentistry are summarized and discussed.
The Association between Sleep and Bone Mineral Density: Cross‐Sectional Study Using Health Check‐up Data in a Local Hospital in Japan
Authors: Yamaura Reiko , Kasahara Hideko , Iimuro Satoshi , Yamazaki Tsutomu 
Published: September 2023

ABSTRACTThis study aimed to investigate the association between daily sleep duration of <7 hours and lower bone mineral density (BMD) using data from annual health check‐ups conducted in Japan between 2020 and 2022. Multivariate regression models were used, where BMD was the objective variable and daily sleep duration (<5 hours, 5 to <7 hours, 7 to <9 hours [reference], ≥9 hours) was the exposure variable adjusted for age, body mass index, physical activity, smoking status, and alcohol intake for men and women and further adjusted for menopausal status for women. The association between insomnia and BMD was also investigated. BMD was determined using calcaneal quantitative ultrasound and expressed as a percentage of the young adult mean (%YAM). In total, 896 men and 821 women were included. Median age was 54 years (interquartile range [IQR]: 46 to 64) for men and 55 years (IQR: 46 to 64) for women). Median BMD for men and women was 79%YAM (IQR: 71 to 89) and 75%YAM (IQR: 68 to 84), respectively. Approximately 80% of men and women slept <7 hours daily. Multivariate regression showed no association between sleep duration and BMD in men. However, women who slept 5 to <7 hours daily had significantly higher BMD by 3.9% compared with those who slept 7 to<9 hours (p = 0.004). No association between insomnia and BMD was found. Overall, a daily sleep duration of <7 hours was not independently associated with lower BMD compared to those who slept 7 to <9 hours in men and women. However, as there is evidence of both shorter and longer sleep durations being associated with an increased risk of adverse events, including cardiovascular events, our result needs to be interpreted with caution. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Current directions in the treatment of classical Hodgkin lymphoma
Authors: Keller Frank G. , Kahl Brad , Friedberg Jonathan W. 
Published: September 2023

AbstractOptimal management of patients who present with Hodgkin lymphoma continues to evolve. Most patients are cured with current treatment strategies, some but both short and long‐term morbidity and mortality from treatment have particular relevance given the youth of the patient population. Combininations of targeted agents together with conventional chemotherapy have recently been investigated in phase 3 cliniial trials for advanced‐stage Hodkgkin lymphoma, and have demonstrated improved efficacy compared with chemotherapy alone. These include both antibody‐drug conjugates and PD‐1 blockade. Treatment approaches have historically differed between pediatric and adult groups, but recent collaborations between adullt and pediatric groups via the NCTN mechanism have resulted in the successful completion of enrollment in an advanced‐stage Hodgkin lymphoma and the opening of an early‐stage trial that will enroll patients accross a broad age spectrum. Novel approachs incorporating targeted and immunomodulatory agents in the relapse setting are being actively investagated in the relapse setting as well.
The pathobiology of select adolescent young adult lymphomas
Authors: Steidl Christian , Kridel Robert , Binkley Michael , Morton Lindsay M. , Chadburn Amy 
Published: September 2023

AbstractLymphoid cancers are among the most frequent cancers diagnosed in adolescents and young adults (AYA), ranging from approximately 30%–35% of cancer diagnoses in adolescent patients (age 10–19) to approximately 10% in patients aged 30–39 years. Moreover, the specific distribution of lymphoid cancer types varies by age with substantial shifts in the subtype distributions between pediatric, AYA, adult, and older adult patients. Currently, biology studies specific to AYA lymphomas are rare and therefore insight into age‐related pathogenesis is incomplete. This review focuses on the paradigmatic epidemiology and pathogenesis of select lymphomas, occurring in the AYA patient population. With the example of posttransplant lymphoproliferative disorders, nodular lymphocyte‐predominant Hodgkin lymphoma, follicular lymphoma (incl. pediatric‐type follicular lymphoma), and mediastinal lymphomas (incl. classic Hodgkin lymphoma, primary mediastinal large B cell lymphoma and mediastinal gray zone lymphoma), we here illustrate the current state‐of‐the‐art in lymphoma classification, recent molecular insights including genomics, and translational opportunities. To improve outcome and quality of life, international collaboration in consortia dedicated to AYA lymphoma is needed to overcome challenges related to siloed biospecimens and data collections as well as to develop studies designed specifically for this unique population.
Scientific techniques in adolescent and young adult classic Hodgkin lymphoma
Authors: Maura Francesco , Adams Ragini M. , Aoki Tomohiro 
Published: September 2023

AbstractUnderstanding the tumor microenvironment and genomic landscape is crucial for better prediction of treatment outcomes and developing novel therapies in Hodgkin lymphoma (HL). Recent advancements in genomics have enabled researchers to gain deeper insights into the genomic characteristics of HL at both single‐cell resolution and the whole genome level. The use of noninvasive methods such as liquid biopsies and formalin‐fixed paraffin‐embedded‐based imaging techniques has expanded the possibilities of applying cutting‐edge analyses to routine clinically available samples. Collaborative efforts between adult and pediatric group are imperative to translate novel findings into routine patient care.
Grip strength in patients with galactosemia and in a galactose‐1‐phosphate uridylyltransferase (GALT)‐null rat model
Authors: Druss Jared J. , Rudd Zhong Manis Josephine , Potter Nancy L. , Fridovich‐Keil Judith L. 
Published: September 2023

AbstractClassic galactosemia (CG) and clinical variant galactosemia (CVG) are allelic inborn errors of metabolism that result from profound deficiency, and near‐profound deficiency, respectively, of galactose‐1‐P uridylyltransferase (GALT). Despite early detection and lifelong dietary restriction of galactose, which is the current standard of care, most patients with CG/CVG grow to experience a range of long‐term developmental and other complications. One of the less well‐understood complications of CG/CVG is decreased hand grip strength, as reported by Potter et al. (2013). Here, we confirm this phenotype in an independent cohort of 36 cases (4–18 years) and 19 controls (4–17 years), and further demonstrate that the grip strength deficit observed in cases may be secondary to growth delay. Specifically, we found that when grip strength of cases and controls in a new cohort recruited in 2022 was plotted by weight, rather than age, the difference between cases and controls for both sexes disappeared. Reanalyzing data from the original 2013 cohort, we found that differences in weight accounted for grip strength differences between cases and controls in girls and young women, but not in boys and young men. Finally, we tested whether a GALT‐null rat model of CG also showed a grip strength deficit—it did—and again the difference between GALT‐null and wild‐type rats associated with differences in body mass. Combined, these results confirm that GALT deficiency is associated with a grip strength deficit in both young patients with CG/CVG and GALT‐null rats, and further demonstrate that this phenotype may be secondary to growth delay, and therefore not evidence of a muscle abnormality.
Simulation and analysis of edge ghosting for microcapsule e‐paper based on particle dynamics and light scattering model
Authors: Zeng Zheng , Liu Yunhe , Liu Guangyou , Yang Jinlan , Yang Mingyang , Zou Guowei , Qin Zong , Wang Xidu , Deng Shaozhi , Yang Bo‐Ru 
Published: September 2023

AbstractElectronic paper (e‐paper) is a reflective display technology with unique advantages, such as bistability, low‐power consumption, and high ambient contrast ratio. These features make e‐paper a promising candidate for future Internet of Things applications. Among different technologies of e‐paper, electrophoretic display (EPD) is the most successful one for commercialization. However, the edge ghosting (also known as the fringing effect) still limits the performance of EPD. Herein, we established a model of particle dynamics of electrophoresis, simulated the edge ghosting of microcapsule EPD, analyzed the edge ghosting effect, and revealed the relationship between thicknesses, dielectric constants of the back binder layer, and the edge ghosting. Two EPD panels with different thicknesses of back binder layer were demonstrated, which verifies the accuracy of this simulation model. With the proposed model, many device mechanisms and product issues can be analyzed and illustrated, which is supposed to guide the researchers in optimizing the device structure design of EPD.
Challenges and Advances of Inland Waters Monitoring: A Case Study Highlighting the Use of Satellite Imagery and Cloud Computing in Brazil
Authors: Carvalho Breylla Campos , Collares Maria Fernanda Antunes , Barbosa Carolina Cerqueira , Figueira Raquel Medeiros Andrade , Fortunato Humberto Freitas de Medeiros 
Published: September 2023

AbstractMonitoring of the quality of inland waters is important to maintain the aquatic ecosystems health and to ensure water quality standards established by environmental laws in each country. Our goal here is to present the possibilities and challenges of water quality mapping based on Sentinel 2 and Landsat 8 satellite images in geographically distinct Brazilian reservoirs as a study case. The satellite images were able to show chlorophyll a, turbidity, and Secchi data trends over 8 years of remote sensing monitoring. The time savings in the analysis of a large dataset and the availability to a wide range of stakeholders make remote sensing a good tool for monitoring inland waters. However, water quality parameters were highly influenced by cloud cover and the accuracy was low at the margin of tributary rivers. The integration of remote sensing and in situ data are needed to increase the effectiveness and accuracy of the remote sensing tools.
BH organization launches AI platform to address recovery gap
Authors: Canady Valerie A. 
Published: September 2023

Observing the need to address the one‐year recovery gap when industry relapse rates are exceedingly high, an Irvine, California‐based behavioral health organization last week announced the launch of a new artificial intelligence (AI)‐driven platform to track patient progress for 12 months after discharge from a behavioral health treatment program.
Agaricus blazei Murrill Polysaccharide Attenuates Periodontitis via H2S/NRF2 Axis‐Boosted Appropriate Level of Autophagy in PDLCs
Authors: Yuan Wenxiu , Huang Maotuan , Wu Yange , Liu Jiaqi , Zhou Xueman , Wang Jun , Liu Jin 
Published: September 2023

ScopePeriodontitis is one of the most prevalent chronic inflammatory diseases with impaired autophagy. Agaricus blazei Murrill polysaccharide (ABMP) shows beneficial effects in various inflammatory diseases. However, whether ABMP is involved in autophagy regulation and periodontitis attenuation remains to be elucidated.Methods and resultsThis study firstly shows the dynamic changes in inflammatory and autophagy levels in silk ligature periodontitis model. Then the positive regulation effect of autophagy on inflammation and its vital role in ABMP inhibiting PDLCs inflammatory response are testified in LPS‐treated PDLCs. Secondly, the Micro‐CT, quantitative RT‐PCR, Western Blot, TRAP, and immunofluorescence staining analysis are performed to assess the effects of ABMP on periodontitis and autophagy. The data show the augmented autophagy and alleviated gingival recession, inflammatory cell infiltration, alveolar bone resorption, and reduced osteoclasts in periodontitis by ABMP treatment. Further experiments using chemical inhibitors demonstrate the vital role of H2S/NRF2 axis in ABMP‐induced appropriate level of autophagy augmentation against periodontitis.ConclusionsCollectively, the findings not only reveal the unrecognized capacity and mechanism of ABMP as an effective and potential dietary intake against periodontitis, but also suggest the possibility for ABMP to be used in the treatment of other autophagy‐related diseases.
Studying the interaction of glycans with intact virions and virus‐like particles by ligand‐observed NMR spectroscopy
Authors: Haselhorst Thomas 
Published: September 2023

AbstractVirus‐glycan interactions play a crucial role in the infection process of many viruses. NMR spectroscopy has emerged as a powerful tool for studying these interactions at the molecular level. In this article, we review several published papers and reports that have highlighted the application of NMR spectroscopy in understanding the complex questions of how viruses engage with and bind to receptor glycans. The use of saturation transfer difference (STD) NMR spectroscopy has demonstrated itself as highly advantageous in investigating the interaction between glycans and intact virions or virus‐like particles (VLPs). The broad NMR signal linewidth of virions and VLPs allows efficient saturation without affecting the glycan signals. The advantage of this approach is that the viral capsid environment in protein organization and function is not ignored and therefore provides a more biologically relevant model for exploring the interactions between the virus and the host cell glycans. We will review some examples of using NMR spectroscopy to study influenza cell tropism, rotaviruses, and noroviruses.