bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circumstances of Occurrence and Post-Exposure Management of Body Fluids related Injuries Among Healthcare Workers in a Regional Level Referral Hospital (Bertoua, Cameroon)
Authors: Takougang Innocent , Cheuyem Fabrice Zobel Lekeumo , Ze Billy Ralph Sanding , Tsamoh Forlemu Fabiola , Moneboulou Hortense Mengong 
Published: October 2023

Abstract
Background
Healthcare workers (HCW) are exposed to infectious agents within biological materials including blood, tissues, other body fluids and on medical supplies, contaminated surfaces within the care delivery environment. The present study aimed to assess the level of exposure to body fluids and their related health risks at the Bertoua Regional Hospital.
Methods
We carried out a hospital-based cross-sectional study from 1st November 2020 to 31st May 2021. The exhaustive sampling method was used and all consenting HCWs were invited to participate. The study instrument was a pre-tested self-administered questionnaire addressing issues related to the experiences, circumstances of occurrence, reporting and management of occupational exposures to body fluids. Data were analyzed using IBM SPSS version 20.4.
Results
The prevalence of accidental exposure to body fluids was 39.2%. Most cases of AEB occurred in the obstetrics and laboratory wards (p = 0.001). Nurses were the most affected professional group (51.7%). Lack of knowledge (79%), patient agitation (49%) were the most reported reasons explaining AEBs occurrence. Half of participants reported using PPE systematically. Face mask (59.2%) and gowns (30.8%) were the most mentioned PPE used to prevent splashes. Most HCWs did not report AEB (62%). Half of the affected HCWs (50.8%) reported that they received a course of post-exposure antiretroviral therapy. The Hepatitis B vaccination coverage was low (8.3%).
Conclusion
Accidental exposure to body fluids affected over 50% of HCWs in the studied Regional Hospital. Most cases of AEB occurred in the obstetrics and laboratory wards and nurses were the most affected professional group. Half of participants reported using PPE systematically. Hepatitis B vaccination coverage was low. There is need to strengthen the observance of standard precautions, including preventive vaccination and the systematic reporting of AEB.
Inhibition of Rab25 correlates with proliferation, apoptosis, and migration of foreskin fibroblasts via the β1- integrin/EGFR pathway in hypospadias
Authors: Zhang Qiang , Zhang Zhicheng , Liu Zhenmin , He Xueyu , Wang Chong , Luo Xingguo , Shen Lianju , Long Chunlan , Wei Guanghui , Liu Xing 
Published: October 2023

Abstract
Hypospadias is a common congenital abnormality of the penile. Abnormal spatiotemporal regulation of critical genes interfering with urethral development leads to hypospadias. This study investigated the role of Rab25 in hypospadias. The expression levels of various molecules in foreskin tissues and fibroblasts were confirmed using PCR, immunohistochemistry, and western blotting. Foreskin fibroblasts of silencing Rab25 were constructed by lentivirus transfection. Using CRISPR/Cas9 technology, Rab25−/− mice were generated. The biological functions of Rab25 were investigated using Cell Counting Kit-8 solution, flow cytometry, and wound scratch assays. The genital tubercles (GTs) of male wild-type (WT) and Rab25−/− fetal mice were collected on gestation day (GD) 18.5, and a scanning electron microscope (SEM) was used to visualize the external morphology of GT. We observed that the foreskin tissues of patients with hypospadias expressed less Rab25, β1-integrin, and EGFR. Moreover, Rab25 inhibition downregulated the β1-integrin and EGFR expressions, restrained proliferation and migration, and promoted apoptosis in foreskin fibroblasts. Abnormal GT morphology with incomplete fusion of the urethral fold and expanded distal cleft was observed in Rab25−/− fetal mice. The distal mild hypospadias phenotype is reproduced in Rab25−/− fetal mice. It suggests that Rab25 plays an important role in the hypospadias via the β1-integrin/EGFR pathway.
Toxicological assessments of agrochemicals in stingless bees in Brazil: a systematic review
Authors: Botina Lorena Lisbetd , Barbosa Wagner Faria , Martins Gustavo Ferreira 
Published: October 2023

Abstract

The growing concern with the decline of pollinators worldwide is centered on honey bees, due to their wide distribution, economic, and ecological importance. This type of concern remained less evident for stingless bees, which are widely distributed in the Neotropics, until recently. Since exposure to agrochemicals has been identified as one of the potential threats to bees, the present systematic review compiled information from toxicological evaluations in stingless bees in Brazil, home to a considerable portion of the existing species. This systematic review was performed considering species, research institutions, scientific journals, metrics, experimental set ups, and agrochemicals. The first article in this topic was published in 2010. Since then, 85 scientific papers were published, which showed that there are few species of stingless bees used for toxicological evaluations and Brazilian institutions lead these evaluations. Only 3.69% of the stingless bees’ species that occur in Brazil were assessed through chronic exposure in the larval stage. The Universidade Federal de Viçosa is responsible for 36.47% of the total publications. The main route of exposure was acute, using adults in laboratory conditions. The main group of agrochemicals studied were insecticides, in particular the neonicotinoids. The current results reveal the advances achieved and point out the gaps that still need to be filled considering toxicological evaluations in stingless bees.
The problem of dairy products adulteration: analysis of the state and ways of resolution
Authors: Khan A. , Lazareva E. , Fomenko O. 
Published: October 2023

The article discusses the problem of the quality of dairy products on the Russian market. The strategic importance of identifying cases of falsification is emphasized Existing methods for its detection are considered, their advantages and disadvantages are described. It is shown that in order to ensure the safety and quality standards of dairy products, it is necessary to regularly monitor raw materials and finished products, introduce a certification system for dairy group products and periodically improve the skills of production employees. Such measures will help prevent the manipulation of dairy products which can adversely affect the health of consumers. To achieve this goal, it is advisable to expand the area of evaluation criteria by a number of methods, including electrophoresis, chromatography, enzyme immunoassay, mass spectrometry, molecular genetics, etc. The article provides recommendations on the most appropriate methods for determining various sources of illegal milk substitution, including the replacement of valuable types of milk cheaper cow. The problem of falsification of dairy products remains relevant, especially in developing and underdeveloped countries. Solving this problem requires the
joint efforts of scientific and regulatory bodies.
Numerical investigation of hydraulic jumps with USBR and wedge-shaped baffle block basins for lower tailwater
Authors: Zaffar Muhammad Waqas , Hassan Ishtiaq , Ali Zulfiqar , Sarwar Kaleem , Hassan Muhammad , Mustafa Muhammad Taimoor , Waris Faizan Ahmed 
Published: October 2023

Abstract

The stilling basin of the Taunsa barrage is a modified form of the United States Bureau of Reclamation (USBR) Type-III basin, which consists of baffle and friction blocks. Studies revealed uprooting of baffle blocks due to their vertical face. Additionally, the literature highlighted issues of rectangular face baffle blocks: less drag, smaller wake area, and flow reattachment. In contrast, the use of wedge-shaped baffle blocks (WSBBs) is limited downstream of open-channel flows. Therefore, this study developed numerical models to investigate the effects of USBR and WSBB basins on the hydraulic jump (HJ) downstream of the Taunsa barrage under lower tailwater conditions. Surface profiles in WSBB and modified USBR basins showed agreement with previous studies, for which the coefficient of determination (R2) reached 0.980 and 0.970, respectively. The HJ efficiencies reached 57.9 and 58.6% in WSBB and modified USBR basins, respectively. The results of sequent depths, roller length, and velocity profiles in the WSBB basin were found more promising than the modified USBR basin, which further confirmed the suitability of the WSBB basin for barrages. Furthermore, WSBB improved flow behaviors in the basin, which showed no fluid reattachment on the sides of WSBB, increased wake regions, and decreased turbulent kinetic energies.
Developing a primal-dual algorithm for optimal planning of groundwater resources
Authors: Zheng Bohong , Huang Yuanyuan 
Published: October 2023

Abstract
The exploitation of water resources to provide water for agriculture follows methods that increase the efficiency of adopted policies. One of the effective ways to improve the efficiency of these systems is to evaluate the role of flow estimation in improving performance indicators such as reliability and vulnerability. In the correlation of water, energy and food, the purpose of decision-making is to achieve a balance between water extraction and energy consumption, which will lead to a reduction in the risk of supplying the water needed by the plant during periods of drought stress. In this article, a decision-making method using discrete wavelet transform and primal-dual algorithm is introduced to estimate the amount of monthly groundwater extraction. The proposed model has been evaluated by the Nash–Sutcliffe method and the mean squared error and optimized to increase the reliability of agricultural water supply. The results indicate the strong role of the accuracy of the proposed method in the efficiency of the aforementioned policies, as it has shown an 8% increase in reliability.
Multimodal Medical Image Fusion based on the VGG19 Model in the
NSCT Domain
Authors: Liu ChunXiang , Wang Yuwei , Cheng Tianqi , Guo Xinping , Wang Lei 
Published: October 2023

Aim:
To deal with the drawbacks of the traditional medical image fusion methods, such
as the low preservation ability of the details, the loss of edge information, and the image distortion,
as well as the huge need for the training data for deep learning, a new multi-modal medical image
fusion method based on the VGG19 model and the non-subsampled contourlet transform (NSCT)
is proposed, whose overall objective is to simultaneously make the full use of the advantages of the
NSCT and the VGG19 model.

Methodology:
Firstly, the source images are decomposed into the high-pass and low-pass subbands by NSCT, respectively. Then, the weighted average fusion rule is implemented to produce
the fused low-pass sub-band coefficients, while an extractor based on the pre-trained VGG19
model is constructed to obtain the fused high-pass subband coefficients.

Result and Discussion:
Finally, the fusion results are reconstructed by the inversion transform of
the NSCT on the fused coefficients. To prove the effectiveness and the accuracy, experiments on
three types of medical datasets are implemented.

Conclusion:
By comparing seven famous fusion methods, both of the subjective and objective
evaluations demonstrate that the proposed method can effectively avoid the loss of detailed feature
information, capture more medical information from the source images, and integrate them into the
fused images.
Computational Investigation of Endophytic Fungal (Penicillium citrinum
CGJ-C2) Compound and Its In-silico Derivatives for the Inhibition of
RNA-Dependent RNA Polymerase of SARS-CoV-2
Authors: Poyya Jagadeesha , Danagoudar Ananda , Joshi Chandrasekhar G , Khandagale Ajay S , Narayanappa Govinda Raju 
Published: October 2023

Background:
The SARS-CoV2 was responsible for the pandemic situation across the
world. SARS-CoV2 is an RNA virus, and its replication depends on RNA Dependent RNA Polymerase (RdRp). Hence, blocking of RdRP would be an alternative strategy to inhibit the virus multiplication without affecting the host physiology.

Objective:
The current study investigated the inhibitory effect of bioactive compound F3 isolated
from P. citrinum CGJ-C2 and its in-silico derivates against RdRp of COVID using computational
methods.

Methods:
Compound F3 and its derivatives were generated computationally, and the crystal structure
of RdRp was processed prior to docking. The RdRp and the bioactive compounds were docked using
Glide with three levels of precisions. Post-docking MMGBSA analysis and Molecular Dynamic simulations were carried out to study the stability of the docking interactions.

Results:
Based on the Glide XP score and MMGBSA analysis of fifteen ligands, three leads were
selected, compound F3 (-8.655 Kcal/mol), D-1(-8.295 Kcal/mol), and D-14(-8.262 Kcal/mol). These
leads (Compound F3, D-1, and D-14) were further evaluated using molecular dynamics (MD) simulation. MD simulations studies showed the stable bonding interaction between LYS500 and ARG569
residues of RdRp with the three lead molecules.

Conclusion:
Our study highlighted the potential of compounds in terms of binding, interaction stability, and structural integrity. Therefore, these leads can be chosen for further studies in in vitro and
in vivo to develop a novel anti-SARS-CoV2 agent with minimal side effects.
Evaluation of the effect of the relationship between diet and microbia on mental health
Authors: Nur Yüksel Gülay , Keskin Gülseren 
Published: October 2023

Introduction. The human body is home to hundreds of different types of microbes [bacteria, viruses, fungi], most of which are found in the gut. In recent years, studies have evaluated the impact of the gut microbiota on brain health, and there has been increasing emphasis on the role of dietary habits in supporting optimal mental health.
Aim. In this study, it is aimed to review the studies on the effect of the relationship between the microbiota-gut-brain axis and nutrition on mental health. This study will guide us on which nutrients we should add to our diet for mental health.
Methods. In this study, a narrative synthesis of observational studies covering diet, microbiota, nutrition and mental health was made using pubmed, sciencedirect and google scholar’s databases. Studies are included if they include the result of microbiota and mental health, diet and mental health, the effect of nutrition on mental health, food groups and its relationship with mental diseases.
Overview. The regulation of the interaction between the gut and the brain through a healthy diet is important in the treatment of common mental disorders and in the prevention of disease.
Conclusions. By changing nutritional habits, microbiota can be changed, mental health can be protected and mental disorders that may occur can be prevented. Healthy eating habits can be emphasized by working on more food and patient groups in this area.
Narcissism and Entrepreneurship: Evidence from Malaysia Realm
Authors: Ali Azrin , Khan Yasmin Kamall 
Published: October 2023

In ensuring the success of an entrepreneurial endeavor, multiple factors come into play. One important aspect is the personality trait of said individual such as narcissism. In Malaysia, there are studies conducted on narcissism in publicly listed companies and CEOs’ earnings management, but lacking research on entrepreneurs and their impact on business performance. This conceptual paper aims to explore the level of narcissism in Malaysian entrepreneurs and how narcissistic traits impact businesses. The theory of Stimulus-Organism-Response is used as the underpinning foundation for framing the relations of the variables to narrow the gap of understanding entrepreneurs’ narcissistic traits impact specifically in the Malaysian region. After reviewing abundant related literature, three main factors are poised as the stimulus portion of the framework; risk-taking activities, propensity towards entrepreneurship, and business competencies. Meanwhile, the organism portion is represented by the narcissistic trait, and the response portion is evaluated in terms of business performance. The implication of this paper is to spur a more in-depth probe into this matter and further enhance entrepreneurs’ successes in the future with preventive measures.
Emotional intelligence, sociodemographic, and investment decision: the moderating effect of financial literacy
Authors: Puspita Nindi Vaulia , Mansor Aida Azlina , Yuliari Kartika 
Published: October 2023

This study aims to determine the effect of emotional intelligence,
sociodemographic factors on investment decisions, and financial literacy as moderating variables of emotional intelligence and sociodemographic factors on investment decisions. The research population is investor saham pemula (ISP) community, a sample of 106 investors. The analysis technique used in this research uses the help of the Smart PLS 3.0 data processing application. the results of the study indicate that Emotional Intelligence has a positive and significant effect on investment decisions; Sociodemography has no effect on investment decisions; Emotional intelligence is positive and significant to investment decisions moderated by financial literacy; positive and significant sociodemography on investment decisions moderated by financial literacy
UPAYA MENINGKATKAN HASIL DAN MINAT BELAJAR MATEMATIKA SISWA SAAT MENERAPKAN PTMT
Authors: Rizki Nanda Arista , Asnawati Asnawati , Watulingas Jefferson R. 
Published: October 2023

This study aims to determine how implementing the Project Based Learning (PjBL) learning model can improve the results and interest in learning mathematics for Class VII Students of SMPN 27 Samarinda when implementing Limited Face-to-Face Meetings (LFFM) in the pandemic situation. This study used a qualitative approach with the Classroom Action Research (CAR) type. Data collection techniques in this study used instruments, i.e., observation sheets, LKPD, LKPJ, final cycle tests, and questionnaires on students' interest in learning mathematics. The research subjects were 31 students in class VII-A, and the object of research was the PjBL model with a scientific approach. The research subjects were 31 students in class VII-A, and the object of research was the PjBL model with a scientific approach. The results of the data analysis showed an increase in the average value of student learning outcomes and interest in each cycle and ended up in the third cycle. The percentage of students who completed increased starting from 25.8% in Cycle I, then 74.2% in Cycle II, and ended with 87.1% in Cycle III. Meanwhile, the number of students who were at least interested also increased from 55% in Cycle I, then 65% in Cycle II, ending with 87% in Cycle III. The PjBL model was successfully implemented due to discussions on different action plans with observers, which were carried out following the results of the previous cycle's reflections.
SOLVING WORD PROBLEMS STRATEGIES BY FIFTH-GRADE STUDENTS
Authors: Mardliyana Millah , Amir Mohammad Faizal 
Published: October 2023

This study aims to identify fifth-grade elementary school students' problem-solving strategies for solving word problems. This research uses a qualitative research approach with a case study research type. Data collection techniques employed tasks, observation, interviews, and documentation. The data analysis techniques used are data reduction, data presentation, and conclusion drawing or verification. The subjects in this study were 32 fifth-grade students of SDN Winong II. This study found four strategies that students used to solve word problems about arithmetic: applying reasoning, multiplying a set of objects, adding parts, and dividing the whole by the unit. The results of this study show that students at the elementary school level have their own strategies for solving word problems. The results of this study have implications for learning. Teachers should provide opportunities for students to explore and use their respective student strategies first in solving word problems. This is done before the teacher explains the correct solution to avoid learning and teaching that requires students to imitate the teacher's word problem solving strategy.
PENGEMBANGAN BAHAN AJAR BERBASIS PROBLEM BASED LEARNING (PBL) BERBANTUAN MEDIA ISPRING UNTUK MENINGKATKAN HASIL BELAJAR SISWA
Authors: Manurung Muhammad Zakaria , Irawan Bambang , Siregar Rosliana 
Published: October 2023

This research produced a Problem Based Learning (PBL)-based teaching material product assisted by iSpring Suite 10 on geometry transformation material. Private high school student Amir Hamzah has no electronic teaching material, so students study hard. The technique used in this study was to provide questionnaire sheets to measure product validation and practicality, and test sheets to measure the improvement of student learning outcomes. The sample of this study was all grade XI students of SMAS Amir Hamzah Medan. This research uses the Dick and Carey development model. The instruments used in this study are observation sheets, interview sheets, a valiantal questionnaire, a practical questionnaire, a pretest sheet, and a posttest sheet. Based on the results of material validation, media and language obtained an overall average of 88% with reliability of 1,382. This shows that this teaching material is very valid and the level of feasible is high and can be used. The results of the trial obtained student responses based on questionnaires of 66% with practical criteria and student learning outcomes showed an average percentage of 79% with effective criteria. The increase in student learning outcomes was obtained 0.54 with moderate criteria using the N-gain scale. This shows that there is an improvement in student learning outcomes after using iSpring Suite 10-assisted Problem Based Learning (PBL) teaching materials on geometry transformation materials.
PENGEMBANGAN E-MODUL INTERAKTIF DISERTAI NILAI-NILAI ISLAM PADA MATERI MATRIKS
Authors: Ramadhani Neli , Farida Nurul , Anwar Rahmad Bustanul 
Published: October 2023

This study aims to produce an interactive e-module accompanied by Islamic values on a valid and practical matrix material. This type of research is Research and Development (R&D). The subjects of this research are students of class XI Multimedia at SMK Negeri 1 Purbolinggo. The development steps in this research use ADDIE (Analysis, Design, Development, Implementation and Evaluation). The instruments used in this study were expert validation questionnaire sheets and student response questionnaire sheets. An expert validation questionnaire was used to assess the validity of the interactive e-module and a student response questionnaire to assess the practicality of the interactive e-module. The results of the study concluded that the interactive e-module accompanied by Islamic values in the matrix material developed had met the valid criteria. Based on the results of the assessment of material experts, design experts and Islamic values experts, a percentage of 87.8% was obtained in the very feasible category. Based on the practical results of the interactive e-module, it meets the very practical criteria with a practicality percentage of 99%. Based on the criteria obtained, the interactive e-module accompanied by Islamic values in the matrix material developed meets the valid and practical criteria