bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaya Kepemimpinan, Motivasi Dan Kinerja Karyawan Akper Saifuddin Zuhri Indramayu Tahun 2022
Authors: Kuspini Ani 
Published: September 2023

Institusi yang mampu bersaing dalam pasar adalah institusi yang mampu menyediakan gaya kepemimpinan yang berkualitas dan efektif sehingga dapat meningkatkan kualitas pendidikan. Organisasi akan stabil dan kondusif bila adanya kerjasama dan hubungan yang baik antara pemimpin dengan bawahannya dan peningkatan kinerja yang baik serta membawa kemajuan bagi organisasi untuk dapat bertahan dalam suatu persaingan lingkungan bisnis yang tidak stabil. Oleh karena itu, upaya untuk meningkatkan kinerja karyawan merupakan tantangan bagi pemimpin dalam memilih gaya kepemimpinan yang diterapkan pada organisasi. Sebagai objek penelitian adalah Akademi Keperawatan Saifuddin Zuhri Indramayu dengan metode total sampling , tujuan dari penelitian adalah untuk mengetahui pengaruh gaya kepemimpinan dan motivasi terhadap kinerja karyawan . Penelitian ini merupakan penelitian kausal dengan menggunakan pendekatan survei. Data yang digunakan adalah informasi primer dan sekunder, soal kuesioner disediakan pilihan jawaban dengan aturan berdasarkan skala Likert 5 poin . Tahapan pengujian data yaitu validasi data dan uji reliabilitas serta uji hipotesis. Variabel dalam penelitian ini adalah variabel bebas Gaya Kepemimpinan dan Motivasi, variabel dependen adalah Kinerja. Analisis data menggunakan metode partial least squares (PLS) dalam model persamaan struktural (SEM). Dari hasil penelitian dapat disimpulkan bahwa uji validitas dan uji reliabilitas semua kuesioner memenuhi persyaratan. Dari uji parsial variabel gaya kepemimpinan berpengaruh positif terhadap kinerja karyawan sementara motivasi kerja secara parsial berpengaruh positif dan signifikan terhadap kinerja karyawan dan berdasarkan persamaan regresi menunjukkan bahwa variabel motivasi berpengaruh lebih besar terhadap kinerja karyawan . Secara simultan uji kedua variabel berpengaruh postif dan signifikan terhadap kinerja karyawan, dan uji koefisien determinasi kedua variabel gaya kepemimpinan dan motivasi, dapat menjelaskan variabel kinerja karyawan.
A holistic approach to preventing type 2 diabetes in Asian women with a history of gestational diabetes mellitus: a feasibility study and pilot randomized controlled trial
Authors: Liew Seaw Jia , Soon Chun Siong , Chooi Yu Chung , Tint Mya Thway , Eriksson Johan Gunnar 
Published: September 2023

BackgroundGestational Diabetes Mellitus (GDM) exposes women to future risk of Type 2 Diabetes. Previous studies focused on diet and physical activity, less emphasis was given to tackle intertwined risk factors such as sleep and stress. Knowledge remains scarce in multi-ethnic Asian communities. This study explored the: (1) feasibility of a holistic digital intervention on improving diet, physical activity (PA), sleep and stress of Asian women with a history of GDM, and (2) preliminary efficacy of the holistic intervention on women’s physical and mental well-being via a pilot randomized controlled trial.MethodsFemale volunteers with a history of GDM but without pre-existing diabetes were recruited from multi-ethnic Singaporean community. Each eligible woman was given a self-monitoring opportunity using Oura Ring that provided daily feedback on step counts, PA, sleep and bedtime heart rate. Intervention group additionally received personalized recommendations aimed to reinforce healthy behaviors holistically (diet, PA, sleep and stress). Dietary intake was evaluated by a research dietitian, while step counts, PA, sleep and bedtime heart rate were evaluated by health coaches based on Oura Ring data. Perceived physical and mental health and well-being were self-reported. Clinical outcomes included glycemic status determined by HbA1c and OGTT tests, body mass index, blood pressures and lipid profile.ResultsOf 196 women from the community, 72 women completed diabetes screening, 61 women were eligible and 56 women completed the study. The 56 completers had mean age of 35.8 ± 3.7 years, predominantly Chinese, majority had their first GDM diagnosed at least 2 years ago and had two GDM-affected pregnancies. After intervention period, more women in the Intervention group achieved at least 8,000 steps/day and had at least 6 hours of sleep per night. Noticeable reduction of added sugar in their food and beverages were observed after the dietary intervention. Changes in body weight and mental well-being were observed but group differences were not statistically significant.ConclusionsThe holistic approach appeared feasible for personalizing lifestyle recommendations to promote physical and mental well-being among women with a history of GDM. Larger studies with sufficient assessment timepoints and follow-up duration are warranted to improve the evaluation of intervention effects on clinical outcomes.Clinical trial registration numberhttps://clinicaltrials.gov/show/NCT05512871, NCT05512871.
An insight into the functional alterations in the gut microbiome of healthy adults in response to a multi-strain probiotic intake: a single arm open label trial
Authors: Rodenes-Gavidia Andrea , Lamelas Araceli , Bloor Sarah , Hobson Anthony , Treadway Sam , Haworth Jordan , Vijayakumar Vineetha , Naghibi Malwina , Day Richard , Chenoll Empar 
Published: September 2023

BackgroundProbiotic supplements, by definition, provide a benefit to the host, but few studies have investigated the effect of probiotic supplements in healthy adult populations.PurposeThe present, single arm, open label clinical trial, evaluated compositional and functional changes in the fecal microbiome of healthy adults after supplementation with a 14-strain probiotic.MethodsWe analysed the effect of a 14-strain probiotic blend (Bacillus subtilis NCIMB 30223, Bifidobacterium bifidum NCIMB 30179, B. breve NCIMB 30180, B. infantis NCIMB 30181, B. longum NCIMB 30182, Lactobacillus helveticus NCIMB 30184, L. delbrueckii subsp. bulgaricus NCIMB 30186, Lacticaseibacillus paracasei NCIMB 30185, Lactiplantibacillus plantarum NCIMB 30187, Lacticaseibacillus rhamnosus NCIMB 30188, L. helveticus NCIMB 30224, Lactobacillus salivarius NCIMB 30225, Lactococcus lactis subsp. lactis NCIMB 30222, and Streptococcus thermophilus NCIMB 30189), on the faecal microbiota of healthy young adults (n=41) in a single arm study. The adults consumed 4 capsules daily of the 14 strain blend(8 billion colony forming units/day) for 8 weeks. Compositional and functional changes in faecal microbiota before and after supplementation were assessed using shotgun metagenomic sequencing. Fasting breath analysis, faecal biochemistry and bowel habits were also assessed.ResultsIn healthy adult participants, no significant changes to the overall alpha- or beta-diversity was observed after 8 weeks of multi-strain probiotic supplementation. However, in a simplified model that considered only time and individual differences, significant decreases (p &lt; 0.05) in family Odoribacteraceae and Bacteroidaceae abundance and a significant increase (p &lt; 0.05) in genus Megamonas abundance were observed. At a functional level, there were significant changes in functional gene abundance related to several functional pathways, including phenylalanine metabolism, O-antigen nucleotide sugar biosynthesis, bacterial chemotaxis, and flagellar assembly. No significant changes in stool form or frequency, fecal biochemistry, or methane and hydrogen breath tests were observed.ConclusionIn healthy young adults, overall alpha- and beta-diversity did not change in response to probiotic intake even though modest compositional changes at the family and genus level were observed. However, at functional level, results identified changes in gene abundance for several functional pathways.
Microbiome–transcriptome analysis reveals that dietary supplementation with macleaya cordata extract alters multiple immune pathways with minimal impact on microbial structure
Authors: Wu Jian , Zhang Xiaoli , Zhou Chuanshe , Jiao Jinzhen , Tan Zhiliang 
Published: September 2023

BackgroundAs a potential antibiotic alternative, macleaya cordata extract (MCE) has anti-inflammatory, antioxidant, and antimicrobial properties. This study was conducted to assess the impact of MCE supplementation on the gut microbiota and its interplay with the host in young goats. Thirty female black goats with similar body weight (5.63 ± 0.30 kg) were selected and randomly allotted into one of three diets: a control diet (Control), a control diet with antibiotics (Antibiotics, 21 mg/kg/day vancomycin and 42 mg/kg/day neomycin), and a control diet with MCE (MCE, 3.75% w/w premix).ResultsPrincipal coordinate analysis of the microbial community showed that samples of Antibiotic clustered separately from both Control and MCE (p &lt; 0.001). The random forest analysis revealed that, in comparison to the Control group, the impact of Antibiotics on the microbiota structure was more pronounced than that of MCE (number of featured microbiota, 13 in Antibiotics and &gt;6 in MCE). In addition, the pathways of significant enrichment either from DEGs between Antibiotics and Control or from DEGs between MCE and Control were almost identical, including Th17 cell differentiation, butanoate metabolism, T-cell receptor signaling pathway, intestinal immune network for IgA production, antigen processing and presentation, and ABC transporters. Furthermore, an integrative analysis indicated that significant positive correlations (p &lt; 0.05) were observed between HEPHL1 and the featured biomarkers Atopostipes, Syntrophococcus, Romboutsia, and Acinetobacter in the MCE group. Conversely, several significant negative correlations (p &lt; 0.05) were identified between HEPHL1 and the featured biomarkers Clostridium_XlVa, Phascolarctobacterium, Desulfovibrio, Cloacibacillus, Barnesiella, Succinatimonas, Alistipes, Oscillibacter, Ruminococcus2, and Megasphaera in the Antibiotics group.ConclusionCollectively, the analysis of microbiome–transcriptome data revealed that dietary supplementation with MCE produced significant alterations in multiple immune pathways, while having minimal impact on the microbial structure.
Guidance on left bundle branch pacing using continuous pacing technique and changes in lead V1 characteristics under real-time monitoring
Authors: Zheng Nan , Jiang Longfu , Shen Jiabo , Zhong Jinyan 
Published: September 2023

BackgroundThe changes in the morphology and characteristics of the V1 leads during left bundle branch capturing still need to be fully understood.ObjectiveThis study aims to provide some suggestions about the LBB capture process through the morphology and characteristics of the V1 lead.MethodLBBP using the continuous pacing and morphology monitoring technique during screw-in using a revolving connector (John Jiang's connecting cable). The morphology and features of V1 leads are recorded by continuous monitoring technology.ResultsThe most common morphology in the LVSP stage is QR, while in the NS-LBBP (low output) stage and the NS-LBBP (lower output) stage, it is rSR. In the S-LBBP stage, it is rsR. The predominant morphology is with r/R waves in S-LBBP, which includes variations like rSR, rsR, rSr, rsr, rR, rs, rS, and R type, making up 96.7% of the total. The r waves in lead V1 are associated with agitated myocardium conducted from the left bundle branch.ConclusionThe initial r-wave in lead V1 may be a marker during the follow-up of patients with selective LBB capture.
Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death
Authors: Carignon Sandra , De Moura Rodrigues Dorian , Gosset David , Culerier Elodie , Huot-Marchand Sarah , Savigny Florence , Kaya Eric , Quesniaux Valerie , Gombault Aurélie , Couillin Isabelle , Ryffel Bernhard , Le Bert Marc , Riteau Nicolas 
Published: September 2023

IntroductionThe pathogenesis of chronic lung diseases is multifaceted with a major role of recurrent micro-injuries of the epithelium. While several reports clearly indicated a prominent role for surfactant-producing alveolar epithelial type 2 (AT2) cells, the contribution of gas exchange-permissive alveolar epithelial type 1 (AT1) cells has not been addressed yet. Here, we investigated whether repeated injury of AT1 cells leads to inflammation and interstitial fibrosis.MethodsWe chose an inducible model of AT1 cell depletion following local diphtheria toxin (DT) administration using an iDTR flox/flox (idTRfl/fl) X Aquaporin 5CRE (Aqp5CRE) transgenic mouse strain.ResultsWe investigated repeated doses and intervals of DT to induce cell death of AT1 cells causing inflammation and interstitial fibrosis. We found that repeated DT administrations at 1ng in iDTRfl/fl X Aqp5CRE mice cause AT1 cell death leading to inflammation, increased tissue repair markers and interstitial pulmonary fibrosis.DiscussionTogether, we demonstrate that depletion of AT1 cells using repeated injury represents a novel approach to investigate chronic lung inflammatory diseases and to identify new therapeutic targets.
AutoML accurately predicts endovascular mechanical thrombectomy in acute large vessel ischemic stroke
Authors: Raj Rishi , Kannath Santhosh Kumar , Mathew Jimson , Sylaja P. N. 
Published: September 2023

Background and objectiveAutomated machine learning or autoML has been widely deployed in various industries. However, their adoption in healthcare, especially in clinical settings is constrained due to a lack of clear understanding and explainability. The aim of this study is to utilize autoML for the prediction of functional outcomes in patients who underwent mechanical thrombectomy and compare it with traditional ML models with a focus on the explainability of the trained models.MethodsA total of 156 patients of acute ischemic stroke with Large Vessel Occlusion (LVO) who underwent mechanical thrombectomy within 24 h of stroke onset were included in the study. A total of 34 treatment variables including clinical, demographic, imaging, and procedure-related data were extracted. Various conventional machine learning models such as decision tree classifier, logistic regression, random forest, kNN, and SVM as well as various autoML models such as AutoGluon, MLJAR, Auto-Sklearn, TPOT, and H2O were used to predict the modified Rankin score (mRS) at the time of patient discharge and 3 months follow-up. The sensitivity, specificity, accuracy, and AUC for traditional ML and autoML models were compared.ResultsThe autoML models outperformed the traditional ML models. For the prediction of mRS at discharge, the highest testing accuracy obtained by traditional ML models for the decision tree classifier was 74.11%, whereas for autoML which was obtained through AutoGluon, it showed an accuracy of 88.23%. Similarly, for mRS at 3 months, the highest testing accuracy of traditional ML was that of the SVM classifier at 76.5%, whereas that of autoML was 85.18% obtained through MLJAR. The 24-h ASPECTS score was the most important predictor for mRS at discharge whereas for prediction of mRS at 3 months, the most important factor was mRS at discharge.ConclusionAutomated machine learning models based on multiple treatment variables can predict the functional outcome in patients more accurately than traditional ML models. The ease of clinical coding and deployment can assist clinicians in the critical decision-making process. We have developed a demo application which can be accessed at https://mrs-score-calculator.onrender.com/.
Analysis of public food procurement in relation to dairy products and their quality criteria
Authors: Brukało Katarzyna M. , Nowak Justyna , Fras Neza , Kowalski Oskar , Gabrijelčič Blenkuš Mojca 
Published: September 2023

IntroductionPublic procurement of food is key to ensuring proper nutrition with high-quality products in public institutions such as schools and kindergartens. However, it should not be considered a mandatory expenditure from public finances but rather an investment in health promotion.Materials and methodsA total of 1,126 public procurement orders processed by schools and kindergartens in Poland during the period from November 2022 to March 2023 were analyzed. Ultimately, 197 public procurement orders meeting the inclusion criteria were considered for analysis. Based on these orders, 2,753 food products classified as dairy and its derivatives were extracted. The ordered quantities of individual products were analyzed, as well as their descriptions (quality characteristics).ResultsCriteria related to composition were most commonly described, the most common criterion was the fat content and the absence of preservatives. On the second places were organoleptic characteristics, where taste and consistency expectations were most frequently specified. Sustainable public procurement criteria were the least frequently mentioned and were treated as highly marginal.ConclusionIntroducing minimum standards for the descriptions of dairy products in terms of organoleptic characteristics, composition features, and sustainability criteria will improve the quality of dairy products supplied to public institutions, particularly schools and kindergartens.
Effects of high-definition transcranial direct current stimulation on the cortical−muscular functional coupling and muscular activities of ankle dorsi−plantarflexion under running-induced fatigue
Authors: Zhan Jianglong , Yu Changxiao , Xiao Songlin , Shen Bin , Zhang Chuyi , Zhou Junhong , Fu Weijie 
Published: September 2023

Transcranial direct current stimulation (tDCS) can improve motor control performance under fatigue. However, the influences of tDCS on factors contributing to motor control (e.g., cortical−muscular functional coupling, CMFC) are unclear. This double-blinded and randomized study examined the effects of high-definition tDCS (HD-tDCS) on muscular activities of dorsiflexors and plantarflexors and CMFC when performing ankle dorsi–plantarflexion under fatigue. Twenty-four male adults were randomly assigned to receive five sessions of 20-min HD-tDCS targeting primary motor cortex (M1) or sham stimulation. Three days before and 1 day after the intervention, participants completed ankle dorsi–plantarflexion under fatigue induced by prolonged running exercise. During the task, electroencephalography (EEG) of M1 (e.g., C1, Cz) and surface electromyography (sEMG) of several muscles (e.g., tibialis anterior [TA]) were recorded synchronously. The corticomuscular coherence (CMC), root mean square (RMS) of sEMG, blood lactate, and maximal voluntary isometric contraction (MVC) of ankle dorsiflexors and plantarflexors were obtained. Before stimulation, greater beta- and gamma-band CMC between M1 and TA were significantly associated with greater RMS of TA (r = 0.460–0.619, p = 0.001–0.024). The beta- and gamma-band CMC of C1-TA and Cz-TA, and RMS of TA and MVC torque of dorsiflexors were significantly higher after HD-tDCS than those at pre-intervention in the HD-tDCS group and post-intervention in the control group (p = 0.002–0.046). However, the HD-tDCS-induced changes in CMC and muscle activities were not significantly associated (r = 0.050–0.128, p = 0.693–0.878). HD-tDCS applied over M1 can enhance the muscular activities of ankle dorsiflexion under fatigue and related CMFC.
Being more satisfied with romantic relationship status is associated with increased mental wellbeing in people with experience of psychosis
Authors: White Rebecca , Haddock Gillian , Haarmans Maria , Varese Filippo 
Published: September 2023

AimsRomantic relationships represent one of the most salient sources of social support. In general population studies, they are associated with both physical and psychological benefits. Research suggests that for people with psychosis, romantic relationships may also have a positive impact on a range of outcomes, but the reasons for these associations are still unclear. This study aims to investigate whether satisfaction with romantic relationships status is associated with better wellbeing outcomes in people with experience of psychosis and explore three possible psychological mediators of this relationship.MethodsParticipants who had previously sought support for psychosis (n = 190) completed an online survey including measures of relationship status satisfaction (the Satisfaction with Relationship Scale) as well as measures of psychotic symptoms (the CAPE-42), general well-being (Short Warwick-Edinburgh Mental Wellbeing Scale) and several psychological variables relevant to the pathway between romantic relationships and well-being outcomes, namely loneliness, internalised stigma, self-esteem and attachment.ResultsFearful attachment and partner criticism were negatively associated with relationship status satisfaction. Having a partner was positively associated with relationship status satisfaction. Higher levels of relationship status satisfaction were associated with lower psychotic symptoms and higher mental wellbeing. This relationship was mediated by loneliness, internalised stigma, and self-esteem.ConclusionMental health services should be mindful of the associations between romantic relationship satisfaction and wellbeing. Service users with a fearful attachment style may particularly benefit from support in this area.
VIVÊNCIAS DE UNIVERSITÁRIOS DE ENFERMAGEM E MEDICINA SOBRE A VIOLÊNCIA CONTRA A PESSOA IDOSA
Authors: Juliana Ribeiro da Silva Vernasque  , Maria Clara de Sousa Santos  , Ana Laura Lopes Loosli  , Laura Vezali Santiago  , Larissa Rodrigues  , Maria José Sanches Marin  
Published: September 2023

Com o aumento da expectativa de vida e a redução da taxa de natalidade, no Brasil, assim como no mundo todo, tem ocorrido um intenso processo de envelhecimento da população, sendo que as pessoas idosas são consideradas mais vulneráveis, devido a diminuição da autonomia, por ficarem expostas a mais fatores de risco, conflitos sociais, familiares e a violência. Sendo assim, a violência contra a pessoa idosa trata-se de um importante problema de saúde pública e carece de intervenções dos profissionais da saúde, os quais devem receber formação para tal abordagem. Objetivo: Interpretar as vivências de jovens universitários dos cursos de enfermagem e medicina, de uma instituição brasileira do interior paulista, sobre a violência contra pessoa idosa. Método: Trata-se de uma pesquisa qualitativa, que utilizou a Teoria Fundamentada nos Dados e como técnica de coleta de dados, entrevistas semiestruturadas com oito estudantes dos cursos de enfermagem e de medicina de uma instituição do interior do estado de São Paulo. Realizou-se análise dos dados no software NVIVO, seguindo as etapas propostas pelo referencial escolhido. Resultados e discussão: Os entrevistados percebem que a violência contra a pessoa idosa tem pouca visibilidade, relataram aproximações com a temática, além de citarem os tipos de violência que a pessoa idosa pode sofrer. Reconheceram as necessidades de saúde da pessoa idosa relacionando com a integralidade do cuidado, interligando com pensamentos sobre o envelhecimento como uma causa natural e propondo intervenções para diminuição deste agravo. Finalizando, expuseram suas ações caso vivenciem uma situação de violência e a possibilidade do tema violência contra a pessoa idosa ser introduzido na grade curricular formal. Conclusão: Evidenciou a pouca visibilidade da pessoa idosa, bem como a necessidade de ações e intervenções educativas para o reconhecimento deste agravo, sendo um passo possível e viável.