bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simplified analysis method for estimating the peak responses of recentering structures with viscous damping systems
Authors: Li Junlin , Wang Wei , Kusunoki Koichi , Maida Yusuke , Wang Zelin 
Published: October 2023

AbstractRecentering structure with a viscous damping system is an emerging structural system with remarkable seismic resilience. This system can exhibit sufficient energy‐dissipating capacity during a major earthquake and eliminate the residual deformation through recentering mechanism afterward. However, the seismic response of the considered system is still confusing due to its complex dynamic behavior. Thus, it is hard to estimate the peak responses of the system during a major earthquake. This study proposes a simplified analysis method for estimating the peak responses of recentering structures with viscous damping systems based on an equivalent two‐stage substitute model. Considering the considerable strain energy of recentering structures during vibrations, this method proposes to employ effective stiffness based on the equal‐energy principle in an equivalent two‐stage substitute model. Based on this concept, corresponding equations are derived for capturing the peak transient responses of the considered system. Results of response history analysis validate that the proposed method can reasonably estimate maximum relative displacement, relative velocity, and absolute acceleration. Given its satisfactory accuracy, this method is promising while conducting seismic design of recentering structures with viscous damping systems.
Rooting performance of cassava cuttings due to the number of nodes and rooting media
Authors: Muktar Halima , Beshir Hussien Mohammed , Tadesse Tesfaye , Haile Ashenafi 
Published: October 2023

AbstractCassava is a major food security crop in the developing world, providing a basic diet for over half a billion people. Stem cutting is the major propagation technique in commercial cassava production, despite its limitations in bulkiness and high cost. Research is lacking in optimizing the number of nodes for the most economical use of the planting material. It can be hypothesized that one or two node cuttings can be used in proper rooting media. Hence, a study was conducted to determine the appropriate number of nodes on selected rooting media for better rooting and shoot growth of cassava. A factorial combination of four number nodes (one, two, three, and standard, or 4–6 nodes) and four types of rooting media (sawdust, cocopeat, topsoil, and sand) was used in a completely randomized design with three replications. Nursery and field establishment data were collected. The result revealed that the interaction between the number of nodes and the media significantly (p < 0.05) affected all fresh and dry weights of root and shoot. Sawdust and cocopeat performed best in terms of root number, root length, leaf number, branch number, shoot length, and rooting percentage. Root fresh weight, root dry weight, shoot fresh weight, and shoot dry weight were higher when stem cuttings were planted using two or more nodes on cocopeat or sawdust as compared to planting them on topsoil or sand. The use of two or more nodes on cuttings using cocopeat or sawdust found outstanding results for rooting. However, the standard cutting was better for survival percentage during field establishment. The result confirmed that two nodes of cassava stem cutting are enough for the successful rooting of cassava, and sawdust promotes the rooting of cuttings. Hence, we recommend sawdust as a rooting medium and two or more nodes of stem cuttings of cassava.
Comparison of the effect of hydroxyl propyl methyl cellulose, pectin, and concentrated raisin juice on gluten‐free bread based on rice and foxtail millet flour
Authors: Abdollahzadeh Abolghasem , Vazifedoost Mohsen , Didar Zohreh , Haddadkhodaprast Mohammad Hossein , Armin Mohammad 
Published: October 2023

AbstractThe nutritional and technological challenges of gluten‐free (GF) bread have increased the need for its modification due to the growing demand for this product, especially from celiac patients. Therefore, the present study aims at evaluating the influence of hydroxyl propyl methyl cellulose (HPMC) at 1% and 2% levels, pectin at 1.5% and 2.5% levels, and concentrated raisin juice (CRJ) at 3% and 4% levels on the dough rheological properties and quality of GF bread based on rice and millet flour. The GF bread prepared with HPMC and incorporating CRJ had higher water absorption, dough development time, and dough stability. In addition, the firmness of GF bread during 24–72 h after baking in the presence of 1% HPMC with 3% and 4% CRJ followed by 2.5% pectin incorporating 3% and 4% CRJ showed a significant decrease compared to the control sample. Further, the color index of GF bread was improved with the addition of HPMC and pectin and the L* index decreased in all GF breads with CRJ. The highest volume was occupied by bread containing 1% HPMC. The results demonstrated that GF bread could be produced from a mixture of rice and millet flour and its technological quality was improved by using 1% HPMC and 3% CRJ. Therefore, it has the necessary potential for high‐scale production and consumption among members of the society.
Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease
Authors: Zhang Xuanming , Wang Rongchun , Finiuk Nataliya , Stoika Rostyslav , Lin Houwen , Wang Xue , Jin Meng 
Published: October 2023

AbstractCalendula officinalis flowers, associated with diverse biological effects, could be utilized as functional food ingredients to play a crucial role in human health. In this study, we examined the anti‐PD activity of C. officinalis flower extracts and investigated their bioactive compounds and molecular mechanisms based on LC–MS/MS assay, bioinformatic exploration and in vitro treatment of SH‐SY5Y cells. C. officinalis extracts exhibited significant positive effects on the length and fluorescence density of the dopaminergic neuron region in zebrafish larvae. At 10 μg/mL, the extract restored the length to 96.54% and fluorescence density to 87.77% of the control values, which was equivalent to the effect of a positive drug, indicating the extract's powerful potential to alleviate PD symptoms. Five active compounds, including chlorogenic acid, 3,4‐dicaffeoylquinic acid (DA), rutin, isorhamnetin 3‐O‐glucoside (IG) and calenduloside E (CE) were identified in extracts by LC‐QTOF‐MS/MS. Hsp90α, PI3K and ERK were revealed as core targets of DA, IG and CE in relation to anti‐PD activity. The compounds docked deeply within the pocket region of Hsp90α protein, and their binding energies (∆Gb) were −6.93 kcal/mol (DA), −6.51 kcal/mol (IG) and −3.03 kcal/mol (CE), respectively. Subsequently, they concurrently activated the PI3K/Akt signaling pathway and inhibited the ERK signaling pathway, thereby preventing neuronal death and alleviating neuronal degeneration. These compounds from C. officinalis could be potent nutraceutical agents with protective properties that may shield dopaminergic neurons against the damage caused by PD. Our findings provide a basis for utilizing the C. officinalis flowers in functional foods.
A brief introduction to the detrital zircon U–Pb and Hf isotopic datasets for mainland China and adjacent regions
Authors: Yang Jianghai , Wang Ping , Huang Hu , Hu Xiumian 
Published: October 2023

AbstractImprovements in analytical technique and data processing lead to a large deposit of detrital zircon U–Pb and Hf isotopic data in published journal articles, thesis and reports. With the support of Deep‐time Digital Earth Big Science Program, OneSediment Project conducted a team‐working effort to assemble the detrital zircon U–Pb and Hf isotopic data for mainland China and adjacent regions. Entity‐relationship diagram was constructed for detrital zircon data to determine what information need to be collected. Researchers and students from 13 institutions were organized together to fulfil this task and generated 13 detrital zircon datasets. The assembled datasets totally include 6635 samples and 560,596 analyses. The samples were checked in terms of lithology and stratigraphy according to the latest stratigraphic framework. Collected detrital zircon U–Pb and Hf isotopic data were recalculated for the best U–Pb age and εHf(t) values. They can be used to track crustal growth, tectonic evolution, provenance analysis and palaeogeographical change in regional and, when combined with other dataset, global scales.
Teachers matter in early childhood: The relation between teacher behaviours and executive function development in toddlerhood
Authors: Koşkulu‐Sancar Sümeyye , Blom Elma , van de Weijer‐Bergsma Eva , Grandfield Elizabeth , Verhagen Josje , Mulder Hanna 
Published: October 2023

AbstractThe current study investigates the role of teacher behaviors in toddlers' executive function development. Teachers' (N = 215) emotional and behavioral support and instructional support were observed through classroom observations when children were 2 years old. Selective attention, verbal short‐term memory, and visuospatial working memory of children (N = 876, 48.4% female) were assessed at age 2 (Mage = 28.60 months, SD = 2.83) and 3 (Mage = 42.38 months, SD = 2.47). Teachers' instructional support positively predicted growth in selective attention, but not verbal short‐term memory or visuospatial working memory. Teachers' emotional and behavioral support did not predict the growth in executive function measures. Findings have implications for understanding the role of teacher‐child interactions in executive function development in toddlerhood.
Brain tumor image pixel segmentation and detection using an aggregation of GAN models with vision transformer
Authors: Datta Priyanka , Rohilla Rajesh 
Published: October 2023

AbstractA number of applications in the field of medical analysis require the difficult and crucial tasks of brain tumor detection and segmentation from magnetic resonance imaging (MRI). Given that each type of brain imaging provides distinctive information about the specifics of each tumor component, in order to create a flexible and successful brain tumor segmentation system, we first suggest a normalization preprocessing method along with pixel segmentation. Then creating synthetic images is advantageous in many fields thanks to generative adversarial networks (GANs). In contrast, combining different GANs may enable understanding of the distributed features but it can make the model very complex and confusing. Standalone GAN may only retrieve the localized features in the latent version of an image. To achieve global and local feature extraction in a single model, we have used a vision transformer (ViT) along with a standalone GAN which will further improve the similarity of the images and can increase the performance of the model for detection of tumor. By effectively overcoming the constraint of data scarcity, high computational time, and lower discrimination capability, our suggested model can comprehend better accuracy, and lower computational time and also give the understanding of the information variance in various representations of the original images. The proposed model was evaluated on the BraTS 2020 dataset and Masoud2021 dataset, that is, a combination of the three datasets SARTAJ, Figshare, and BR35H. The obtained results demonstrate that the suggested model is capable of producing fine‐quality images with accuracy and sensitivity scores of 0.9765 and 0.977 on the BraTS 2020 dataset as well as 0.9899 and 0.9683 on the Masoud2021 dataset.
Hemodynamic Effects of Intravenous Famotidine in Patients Undergoing Cardiac Surgery
Authors: Wagner Bertil K.J. , DiFazio Louis T. , Amory David W. , Scott Gregory E. , Spotnitz . Alan J. 
Published: October 2023

Study Objective. To determine the hemodynamic effects of famotidine in patients undergoing cardiac surgery.Design. A prospective, randomized, double‐blinded, placebo‐controlled study.Setting. A large university teaching hospital.Patients. Twenty‐one patients undergoing elective cardiac surgery with cardiopulmonary bypass.Interventions. The patients received a rapid intravenous bolus injection of famotidine 20 mg or saline placebo after anesthesia induction. A second dose was given 12 hours after surgery in the intensive care unit.Measurements and Main Results. Serial hemodynamic measurements (heart rate, arterial blood pressure, cardiac index, pulmonary arterial pressure, central venous pressure, systemic vascular resistance) were obtained after each famotidine or placebo dose and analyzed by ANOVA. The values were not altered (p>0.05) after intraoperative or postoperative famotidine or placebo administration.Conclusions. Rapid intravenous bolus administration of famotidine does not alter patient hemodynamics after anesthesia induction or in the intensive care unit after cardiac surgery.
Lymphocyte β2‐Receptor Activity, Metoprolol Kinetics, and Response to Metoprolol in Hypertensive Black Men
Authors: Johnson Julie A. , Akers Wendell S. , Miller Stephen T. , Applegate William B. 
Published: October 2023

Study Objectives. To evaluate whether variability in S‐metoprolol kinetics and lymphocyte β2‐receptor‐mediated cyclic adenosine monophosphate (cAMP) accumulation is related to the variability in antihypertensive response to metoprolol of black men.Design. Prospective, unblinded study.Setting. University‐based preventive medicine clinic.Patients. Twelve hypertensive black men.Measurements and Main Results. Ambulatory blood pressure was measured over 24 hours before and after metoprolol administration. Ex vivo responsiveness of lymphocyte β2‐receptors to isoproterenol was established for each subject before initiating metoprolol therapy. Plasma samples were collected over 12 hours at the conclusion of the study, from which metoprolol enantiomer concentrations were determined by chiral high‐performance liquid chromatography, and kinetic values were calculated. The 24‐hour ambulatory blood pressure responses to metoprolol were highly variable, with systolic blood pressure responses ranging from −13 to +33 mm Hg and diastolic blood pressure responses ranging from −15 to +15 mm Hg. There was a significant relationship between the metoprolol‐induced change in systolic blood pressure and the maximum lymphocyte β2‐receptor cAMP production (y = 0.47x −7.79; r2 = 0.49, p<0.05) such that those with the highest maximum cAMP production had the greatest blood pressure increases during metoprolol therapy. There was no relationship between S‐metoprolol concentration and blood pressure response. Mean oral clearance values for S‐ and R‐metoprolol were 1320 and 2346 ml/minute, respectively.Conclusions. Lymphocyte β2‐receptor data suggest that individuals most responsive to β‐receptor stimulation may be at greatest risk of blood pressure elevation during β2‐receptor blockade. The metoprolol enantiomer kinetic data are markedly different from previously published data and may represent racial differences in pharmacokinetics.
The long arm of rejection sensitivity and young adults' romantic relationships: An extension and a replication
Authors: Shulman Shmuel , Yonatan‐Leus Refael 
Published: October 2023

AbstractIntroductionIn an earlier study, we followed adolescents from age 16 to 23, examining the effect of rejection sensitivity (RS) on the quality of future romantic relationships. Findings showed that RS decreased over time, and the decrease associated with a higher quality of future romantic relationships. In contrast, the effect of the earlier level of RS on the quality of future romantic relationships was minor.MethodsExtending the earlier study, these 101 Israeli young adults (69 females, mean age = 22.79) were followed again from age 23 to 28. At age 28, the level of RS was assessed again. In addition, participants reported about the quality of their current or most recent romantic relationship.ResultsContrary to the earlier study, findings of the current study show that the earlier higher level of RS at age 23 was associated with a higher likelihood of maintaining distance and self concealing from one's partner, feeling less certain, and reporting greater tension in future relationships. In contrast, the effect of change in RS between ages 23 and 28 on future relationships was minimal.ConclusionsIntegrating the findings of the current and earlier studies underscores the role of earlier RS and its change over time during different developmental periods. RS decreases during the transition from adolescence to adulthood, and this decrease associates with a future higher quality of romantic relationships. In contrast, during the latter 20s RS stabilizes, and therefore, its earlier level associates with future romantic outcomes.
On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters
Authors: Javelle Florian , Schlagheck Marit L. , Broos Hannah C. , Timpano Kiara R. , Joormann Jutta , Zimmer Philipp , Johnson Sheri L. 
Published: October 2023

AbstractBackgroundResearchers have increasingly differentiated trait‐like tendencies toward impulsivity occurring during emotional states (emotion‐related impulsivity [ERI]) from impulsivity not tied to emotion (non‐ERI). Relative to non‐ERI, ERI has shown robust correlations with psychopathology and mild to moderate associations with physical health parameters (e.g., physical activity, poor sleep quality, body mass index [BMI]). Therefore, we first aimed to investigate the unique contributions of ERI and non‐ERI to psychopathology symptoms while controlling for neuroticism. Second, we sought to explore the combined associations of physical health parameters with several impulsivity forms.MethodsGerman‐speaking adults (N = 350, 35.9 ± 14.6 years, 69.1% female, BMI: 24.0 ± 4.8 kg/m2, mostly students or employees) completed measures of impulsivity, psychopathology symptoms, neuroticism, and physical health. We gathered measures of two ERI forms: Feelings Trigger Action and Pervasive Influence of Feelings. As a control comparison, we gathered a measure of non‐ERI, the Lack of Follow‐Through scale. We conducted separate path models for Aims 1 and 2.ResultsFor Aim 1, Pervasive Influence of Feelings showed strong links with internalizing symptoms. Feelings Trigger Action and Lack of Follow‐Through showed small links with alcohol use. For Aim 2, poor sleep quality was related to all three impulsivity factors, while physical activity was only related to Pervasive Influence of Feelings and Lack of Follow‐Through. BMI showed a curvilinear association with impulsivity.ConclusionsERI is more directly relevant than non‐ERI for psychopathology symptoms, emphasizing the need to differentiate between the two ERI types. The association of ERI and non‐ERI with physical activity and poor sleep quality may serve as potential treatment targets for impulsivity‐related problems.
Intrapersonal dynamics of closeness versus distance: Qualities of the self‐concept distinguish destructive overdependence, dysfunctional detachment, and healthy dependency
Authors: Bornstein Robert F. , Thomson Shannon M. 
Published: October 2023

AbstractIntroductionPeople vary in the degree to which they affiliate with others; exaggerated efforts maintain interpersonal closeness versus distance are codified in longstanding categorical models of personality pathology, and in contemporary dimensional frameworks as well.ObjectiveTo examine associations between destructive overdependence (DO), dysfuntional detachment (DD), and healthy dependency (HD) and qualities of the self‐concept.MethodA mixed‐sex sample of 229 adults completed the Relationship Profile Test to assess DO, DD, and HD, and the Object Relations Inventory (ORI) to assess qualities of the self‐concept.Results and ConclusionAnalyses indicated that (1) the ORI Strong dimension was uniquely predictive of DO (inversely related); (2) ORI Warm and Nurturing were unique predictors of DD (both inversely related); and (3) ORI Nurturing and Successful were unique predictors of HD. This study illuminates key intrapersonal features of these three personality styles.
Cumulative trauma and perceived community resilience: A serial mediation model
Authors: Cardinali Paola , Olcese Martina , Antichi Lorenzo , Migliorini Laura 
Published: October 2023

AbstractCommunities affected by cumulative trauma can experience negative psychological reactions but also posttraumatic growth and community resilience, which promote adaptation and preparation for future traumatic events. This study aims to investigate the mechanisms that mediate the relationship between traumatic events and perceived community resilience. Participants were 118 Italian adults who experienced cumulative trauma and were recruited to complete an online survey. A serial multiple mediation model was estimated to assess whether the impact of the Morandi bridge collapse and posttraumatic growth mediated the relationship between the psychological impact of the Covid‐19 pandemic and perceived community resilience. The impact of the collapsed bridge and posttraumatic growth in serial partially mediated the relationship between the impact of the Covid‐19 pandemic and perceived community resilience. The impact of cumulative trauma can be considered through an ecological perspective that considers the consequences of these events in relation to community resilience.
Activation of ITLN‐1 attenuates oxidative stress injury via activating SIRT1/PGC1‐α signaling in neuroblastoma cells
Authors: Niu Xiaochen , Di Wencheng , Zhang Zhe , Li Ning , Qiu Zhenye , Shi Wenzhen , Lei Wangrui , Tang Jaiyou , Yang Yang , Xu Biao , Tian Ye 
Published: October 2023

AbstractCerebral injury is closely associated with enhanced oxidative stress. A newly discovered secretory adipocytokine, intelectin‐1 (ITLN‐1), has been shown to have beneficial effects in neuroprotection in epidemiological studies. However, the specific molecular mechanism of ITLN‐1 in protecting against cerebral oxidative stress needs further investigation. In this study, we hypothesize that ITLN‐1 plays a protective role against oxidative stress injury through the SIRT1/PGC1‐α signaling pathway in neuromatocytes. We used hydrogen peroxide (H2O2) as a oxidative stress model to simulate oxidative stress injury. Then, small interfering RNAs (siRNAs) was used to knock down SIRT1 in N2a cells with or without ITLN overexpression, followed by H2O2‐induced injury. We observed that H2O2 injury significantly decreased the levels of ITLN‐1, SIRT1, and PGC‐1α. However, ITLN overexpression reversed H2O2‐induced decline in cell viability and rise in apoptosis and intracellular ROS levels in N2a cells, while ITLN siRNA worsened the neurocyte injury. Furthermore, SIRT1 knockdown reversed the positive effect of ITLN overexpression on oxidative stress injury in N2a cells. Taken together, these findings suggest that ITLN‐1 exerts neuroprotective effects against oxidative stress injury primarily through the SIRT1/PGC‐1α axis.