bluuebunny/crossref_metadata_2025_split huggingface dataset:
KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India
Authors: Dutta Avisek , Bankura Biswabandhu , Das Madhusudan , Pal Dilip Kumar 
Published: December 2023

Abstract

Objective:
This study aims at detecting KIBRA promoter methylation and association with clinic-pathological manifestations in renal cancer.

Materials and Methods:
In this study, we have studied the KIBRA promoter methylation in twenty cases of renal cell cancer and compared them to their stage, grade, and histopathology.

Result:
We have found that significant amount of KIBRA promoter methylation is present in high grade tumors irrespective of the stage. 5 out of 6 grade III tumors and all 6 grade IV tumors were positive for significant KIBRA promoter methylation as compared to 1 out of 5 grade I tumor.

Conclusion:
DNA methylation alterations participate in renal carcinogenesis which significantly correlated with the clinicopathological diversity of clear cell renal cell carcinomas and can be considered as potential targets for therapy.
A Case of Tracheal Rent Caused by Blunt Trauma to the Anterior Neck
Authors: Michael Binoy , Goje Harindra Kumar 
Published: December 2023

Abstract
Tracheobronchial injury (TBI) is an uncommon and potentially life-threatening injury, but very little data are available to guide the management of the same. TBI due to blunt or penetrating trauma is rare and most individuals succumb to asphyxiation from airway obstruction or tension pneumothorax even before reaching the hospital. We present the case of a 25-year-old male who was brought to the emergency room with a history of blunt trauma to the anterior neck, leading to swelling and pain at the site of injury associated with progressive loss of speech and worsening dyspnoea. Gradually, increasing neck swelling along with progressive loss of phonation and worsening dyspnoea forced us to consider a tracheal injury in this patient. We discuss the sequence of events that lead to the occurrence of tracheal injury, and the prompt diagnosis and efficient management which are the cornerstones in saving the patient’s life.
Assessment of Choice and Anxiety toward Different Dentist’s Attires among 5–12-Year-Old Children in Dental Operatory
Authors: Singh Vaishnavi , Vashisth Pallavi , Naik Sathyajith , Sharma Shivangi 
Published: December 2023

Abstract

Introduction:
Fear and anxiety toward dentists, syringes, and white coats are significant issues affecting the treatment of pediatric patients. According to D.C.I guidelines for the COVID-19 pandemic, it was made mandatory to wear personal protective equipment (PPE) for dental professionals, adding one more cause of fear and anxiety, which made it more challenging to treat pediatric patients. Friendly dentist attire can make a positive impact on a patient’s behavior.

Aim:
This study aimed to assessment of choice for dentist’s attire and their effect on anxiety of 5–12-year-old children.

Materials and Methods:
The present study was conducted in the Department of Pediatric and Preventive Dentistry, IDS, Bareilly. To assess the choice of dentist’s attire, a questionnaire consisting of 15 closed and open-ended questions was formulated and was asked to be filled by 182 patients with the help of their parents, who reported in our operatory. To assess the pre- and postanxiety levels among patients, vitals (blood pressure and pulse rate) and facial image scores were recorded. Data obtained were subjected to statistical analysis.

Results:
Majority of the children, i.e., 58.8%, showed preference for modified PPE with cartoon characters. Facial Image Scale: Score 2, i.e., sad face, was scored by 7% of children at baseline, and was reduced to only 1% after attire selection. Significant differences were seen in physiological parameters.

Conclusion:
Clinician’s attire and appearance play a major role in behavior modification of anxious children. Modified PPE with cartoon characters was the attire of choice for the majority of children.
Management of Acute Gingival Bleeding in Biphasic Dengue Fever with Zinc Oxide Eugenol Dressing
Authors: Vinodh Gangadharan , Balasubramanian Manonmani 
Published: December 2023

Abstract
Gingival bleeding is a common clinical finding associated with plague. It is also associated with systemic diseases, including viral and bacterial infections. Dengue hemorrhagic fever (DHF) is transmitted by virus belongs to Flaviviridae through infected Aedes mosquitoes. Symptoms of dengue fever occur 3 to 14 days after infection and are biphasic, particularly in DHF. We report a case of gingival bleeding following a dental procedure that was controlled with prolonged application of pressure using zinc oxide eugenol pack and was later diagnosed as DHF.
Complex Malocclusion, an Efficient Treatment Option: Tip-Edge Appliance
Authors: Pothuri Ashok , Sunitha Cathrine , Vijayadhith C. 
Published: December 2023

Abstract
Orthodontic treatment has been a boon for many patients who wish to change their esthetic appearance that goes concomitantly with their psychological well-being. This treatment modality has changed strenuous appliance design to simple but excellent result delivering appliances. The duration of orthodontic treatment has always been a major challenge in relation to the patient’s compliance, so the appliance which an orthodontist delivers to a patient should always be efficient and also produce good results in a short period of time. An 18-year-old female patient came to the department of orthodontics with a chief complaint for forwardly placed upper front teeth; upon examination, the patient showed Class II skeletal and dental relation with increased overjet and overbite with horizontal growth pattern. The patient was given Tip-Edge appliance since it can reduce the large overjet in a short duration, and treatment was completed within 13 months. Tip-Edge appliance delivers faster results when compared with other appliances, which helps a lot in the patient’s compliance and satisfaction.
Repeated dose 90-days oral toxicity study of Tala Sindura: An Ayurvedic mercuro-arsenical formulation
Authors: Nirmal Shivani , Dalvi Atul Tatyasaheb , Nariya Mukesh , Chaudhari Swapnil Yashwant , Patgiri Biswajyoti 
Published: December 2023

Abstract

BACKGROUND:

Tala Sindura is one such mercuro-arsenical formulation extensively used in Ayurvedic therapeutics without any noticeable side effects. Despite this, safety concerns have been raised on such Ayurveda formulations containing heavy metals such as mercury and arsenic as an integral component. So, there is a need to generate scientific evidences on safety aspects of such formulations to prove that they are safe and non-toxic.

METHODS:
In current study, safety profile of Tala Sindura has been evaluated through repeated dose 90-days oral toxicity study. Test drug was administered at TED (22.5 mg/kg), TED ×5 (112.5 mg/kg), TED ×10 (225 mg/kg), and RTED ×10 (225 mg/kg) orally once in a day for 90 days along with honey (vehicle) and distilled water in a dose of 5 mL/kg body weight. Safety of Tala Sindura was assessed on the basis of hematological, biochemical, and histopathological changes in Wistar albino rats.

RESULTS:

Tala Sindura did not produce any significant changes in hematological, biochemical and histopathological parameters at TED and TED ×5 dose levels. Mild cell infiltration with edematous changes were observed in kidney at TED ×10 dose level; however, these changes were reversed in recovery control.

CONCLUSION:
From the present study, it is concluded that Tala Sindura is safe for administration at therapeutic dose level when administered for 90 days in rats.
Comparative pharmacognostical, phytochemical, high-performance thin-layer chromatography, Fourier-transform infrared spectroscopy, and ultraviolet spectral studies on leaf and rhizome of Drynaria quercifolia (L.) J. Smith
Authors: Thulasi Radhakrishnan , Misro Lakshminarayana , Maurya Rahul , Thirupataiah Boini 
Published: December 2023

Abstract

BACKGROUND:

Drynaria quercifolia (L.) J.Smith, belonging to the Polypodiaceae family, is widely used in Ayurvedic formulation preparations and is known commonly as Aswakatri in Sanskrit. Usually, its rhizome part is used in the different formulations of Ayurveda Medicine. Many works in pharmacognostical evaluation and phytochemical analysis help reveal plants’ secondary metabolite constituents. Rhizomes or roots of many plants are the significant part used for medicinal purposes. While using these roots or rhizomes, we have to destroy the whole plant. So if the secondary metabolites in the root or rhizome are also present in aerial parts, there is no need to destroy the plant to get the medicinally important molecule. The available literature comparison of leaf and rhizome needs to be better studied.

METHODS:
The present study aims to compare the pharmacognostical and phytochemical contents of the leaf and rhizome of D. quercifolia using Fourier Transform Infrared Spectroscopy (FTIR), Ultraviolet-visible spectroscopy, and High-Performance Thin-Layer Chromatography (HPTLC). Quantitative analysis of plant parts was carried out by estimating total phenolic content (TPC) and Total Flavonoid Content (TFC). Further qualitative analysis of plant parts was carried out by HPTLC using mobile phase toluene:ethyl acetate (9:1, v/v).

RESULTS:
Different spots were observed in the leaf (@ 254 nm—05, 366 nm—07, and 545 nm—05) and rhizome (@366 nm—08 and 545 nm—06) of D. quercifolia. Gallic acid, quercetin, and β-sitosterol are used as a bioactive marker. The β-sitosterol was characteristically observed at 545 nm at R

f
0.28 in both plant parts.

CONCLUSION:
It has been observed that the leaf part of D. quercifolia exhibited more characteristic phytochemical constituents compared to the rhizome part. The TPC, TFC, and HPTLC fingerprint profiles are observed more in the leaf than in the rhizome part.
Acute oral toxicity study of polyherbal formulation: Constac granules
Authors: Porwal Ashwin D. , Bhagwat Gajanan Bhagwan , Kamble Pravin P. , Borate Sudhir 
Published: December 2023

Abstract

BACKGROUND:
Constipation is a common and frequently persistent gastrointestinal motility condition. It affects the economic burden, the standard of living, social interaction, and the capacity to carry out everyday tasks. This study aimed to evaluate the acute oral toxicity of Constac granules in Wistar rats.

METHODS:
A total of 12 rats were randomly divided into four groups of three each. Group 1 served as the control and received only distilled water, while groups 2 and 3 received doses of 2000 mg/kg body weight of Constac granules, and group 4 received doses of 5000 mg/kg body weight of Constac granules. The rats were observed for 14 days for any signs of toxicity. Necropsy was performed on all rats at the termination of the study and gross pathology was recorded.

RESULTS:
The results showed no clinical signs of toxicity or mortality observed in any of the control and treatment groups rats during the 14-day observation period. The LD50 value was estimated to be greater than 5000 mg/kg body weight.

CONCLUSION:
The acute oral toxicity study of Constac granules in Wistar rats showed no toxicity at doses up to 5000 mg/kg body weight. These findings showed that the oral administration of the Constac granules is safe to use.
Baby Finger Toothbrush as an Innovative Alternative for Finger Method of Teeth Cleaning to Improve Oral Hygiene in Rural India
Authors: Kulkarni Praveena Venkatesh , Chaukaskar Mrudula Santosh , Kulkarni Venkatesh Vamanrao , Deshmane Gourav Bharat 
Published: December 2023

Background:
Most of the rural Indian population cleans the teeth with their finger and they find it difficult to switch to a manual toothbrush. To continue their legacy of cleaning the teeth with their finger, we conducted a study with a baby finger toothbrush, which is used by inserting an index finger for brushing the baby’s teeth.

Objective:
The objective of this study was to compare the efficacy of a baby finger toothbrush with teeth cleaning method using finger.

Materials and Methods:
Sixty adults who cleaned their teeth with their fingers were divided into two groups. Those participants who were willing to use baby finger toothbrushes were included in Group A and the remaining participants were part of Group B. A nonrandomized controlled trial study design was used. Group A Participants were asked to use baby finger toothbrushes for 15 days. The oral hygiene index-simplified (OHI-S) was recorded for both the groups on day 1 and after 15 days. We then compared the oral hygiene status for those who use baby finger toothbrush with those who clean the teeth using finger.

Results:
OHI-S was significantly higher in the participants cleaning teeth with their fingers compared to the participants using baby finger toothbrush after 15 days. It showed that using a baby finger toothbrush is more effective than using your fingers to improve oral hygiene. Participants who used the baby finger toothbrush had the median OHI-S of 1.33, which is close to a good OHI-S (good-OHI-S = 0.0–1.2) and indicates that baby finger toothbrush was able to maintain “Fair” oral hygiene.

Conclusion:
To improve oral hygiene in rural India, where most individuals clean teeth with their fingers, a baby finger toothbrush can be used as an improvised method of tooth cleaning.
Dysfunctional Internet Behavior Patterns and its Relation to Oral Health Status among Adolescents in Coimbatore: A Cross-sectional Study
Authors: Jagan P. , Pauline C. Jemimah , Kumar Suchithra Sampath 
Published: December 2023

Aim:
The aim is to assess dysfunctional Internet behavior patterns and their influence on oral health status among adolescents.

Methodology:
A descriptive cross-sectional study was designed and conducted among college-going adolescents in the Coimbatore district. The estimated sample size was 196. This sample was drawn from across the city through a simple random sampling methodology. Data were collected on a specially designed pro forma, which contained three parts.

Statistical Analysis:
Descriptive analysis was carried out. The Chi-square test was used to test statistical significance. Univariate logistic regression analysis of factors associated with risk at Internet Addiction Test in the study population was carried out. P < 0.05 was considered statistically significant.

Results:
There was a difference in the proportion of oral hygiene index scores (χ2 = 52.06), plaque index scores, and gingival index scores across Internet Addiction Tests and were statistically significant (P < 0.05), whereas the Decayed Missing Filled Teeth index scores across Internet Addiction Test was statistically not significant (P = 0.54). Univariate regression analysis revealed that compared to good oral hygiene, the odds of risk at the Internet Addiction Test was 2.7 (95% confidence interval [CI] = 0.8–8.7) times in fair and the association was statistically not significant (P > 0.05). The odds of risk at Internet Addiction Test in poor oral hygiene was 15.5 (95% CI = 4.16–58.11) times, and the association was statistically significant (P < 0.05).

Conclusion:
Our results have indicated that the time spent on the Internet, which is otherwise labeled as “Addiction” in adolescents, is related to the risk of oral health problems.
Assessment of Nicotine Dependence and Readiness to Change among Patients Attending Tobacco Cessation Clinic: A Cross-sectional Study
Authors: Gupta Vinay Kumar , Kankane Nishita , Mishra Gaurav , Kumar Sumit 
Published: December 2023

Background:
Nicotine is the addictive substance present in tobacco which makes quitting tobacco difficult.

Objective:
This study was done to assess nicotine dependence and stage of readiness to change among tobacco users visiting the Tobacco Cessation Clinic (TCC) Lucknow.

Materials and Methods:
A cross-sectional study was performed in the TCC of a Government Dental College. The data were recorded in the tobacco cessation registration forms of tobacco users and then analyzed through statistical software using the Chi-square test.

Results:
The number of tobacco users was more in males (88%) than in females (12%) with a preference for smokeless type (63.4%) of tobacco usage. Most of the tobacco users were of 25–34 years of age group (34.9%). It was also observed that the maximum number of tobacco users was married (68.3%) and had graduate/postgraduate degree (62.3%). It was also seen that usually, the monthly expense on tobacco products by either gender was Rs. 1000–2400. More than 50% of the tobacco users had tried quitting before because of health issues and craving was the main reason for relapse. We also observed that the highest level of nicotine dependence was amongst the smokeless tobacco users with a history of 5–10 years of tobacco use (43.3%).

Conclusion:
It was found that most of the patients who attended the TCC had medium level of dependence on nicotine and where in the preparation phase to quit the habit.
Relationship of Anthropometric Measurements and Nutritional Status with Early Childhood Caries among Rural Preschool Children – A Cross-sectional Analytical Study
Authors: Phogat Ritu , Rani Geeta , Manjunath B. C. , Kumar Adarsh , Rani Vatchala 
Published: December 2023

Objectives:
The objective is to assess the association between anthropometric measurements and nutritional status with early childhood caries among 3–5 years old rural children.

Materials and Methods:
A cross-sectional study was conducted at rural Anganwadi centers (AWCs) among 868 preschool children selected from 80 AWCs centers using a multistage sampling technique. Anthropometric measurements such as weight, height, mid-arm circumference, and head circumference were assessed. The nutritional status of children was calculated based on Z scores using the World Health Organization Anthropometry software version 3.2.2. Dental caries experience was recorded using the International Caries Detection and Assessment System index. SPSS version 20 was used for statistical analysis. The association between nutritional status and dental caries was obtained using correlation and regression analysis.

Results:
Out of the total children examined for the present study 49.65% were male and 50.34% were female. The prevalence of malnutrition among study participants was stunting (15.4%), underweight (7.4%), and wasting (5.0%), respectively. A study reported a negative correlation between body mass index and caries scores (r = −0.094; P = 0.005). Children with stunting, wasting, and underweight, respectively, had 2.3, 4.5, and 8.3 times odds of having dental caries than well-nourished children.

Conclusion:
Children with malnutrition may have higher chances of developing dental caries than their healthy counterparts.
Determining Mathematical Standards for Smile Designing Using Berry’s Biometric Index and the Golden Proportion
Authors: Mall Vidhi Rajesh , Gaikwad Ashwini , Jadhav Madhura Avinash , Patil Rajlaxmi , Chavan Shivani , Ingale Vinaya 
Published: December 2023

Introduction:
Berry’s biometric index correlates the bizygomatic width to the width of the maxillary central incisors (CIs). It has also been suggested that dental and facial esthetics follow the concept of the golden ratio (1.61803). The present research aims to evaluate the practical applicability of Berry’s bizygomatic index and the golden ratio to the width of the maxillary anterior teeth.

Materials and Methods:
The bizygomatic width and the width of all the maxillary anterior teeth were measured for a total sample of n = 100. The width of maxillary CI was calculated by Berry’s biometric index and the other teeth by golden ratio. The measured and calculated values were compared by means of statistical analysis.

Results:
The age of study participants ranged from 19 to 35 years with a mean of 24.99 years (standard deviation = ±5.098). There was no statistically significant difference between the measured and the calculated values (P > 0.05). The relative Dahlberg’s error was found to be low for all the teeth.

Conclusion:
Berry’s biometric index along with golden proportion can be reliably used to determine the mesiodistal width of the maxillary anterior teeth. The methods can be implemented in cases where there is no reference to determine the width of upper anterior teeth during any esthetic restorative procedure. Maxillary anterior teeth dictate the esthetics of a smile; therefore, this study attempts to shed light on the importance of the coherent use of these mathematical ratios to provide an objective formula for smile rehabilitation.
Baseline Serum Albumin Levels for Predicting Progression-free Survival in Patients with Non-Hodgkin Lymphoma: A Single-center Prospective Study in Syria
Authors: Younis Mariam Deeb , Asaad Remal Abdulaziz , Hussein Firas Hasan 
Published: December 2023

Abstract

BACKGROUND AND AIMS:
A low baseline serum albumin (SA) level is considered an adverse prognostic indicator of various solid tumors and hematological malignancies. However, studies evaluating the relationship between SA levels and survival in non-Hodgkin lymphoma (NHL) patients are limited in Syria. Thus, this is the first study to assess the impact of baseline SA as an independent prognostic factor on progression-free survival (PFS) over 18 months (1.5 years) in Syrian NHL patients.

METHODS:
We prospectively analyzed patients diagnosed with de novo NHL who met the inclusion criteria and were admitted to the Chemotherapy and Radiotherapy Center at Tishreen University Hospital (TUH) in Latakia, Syria, between January 2021 and December 2021. The baseline SA concentration was measured. The PFS rate was estimated using the Kaplan–Meier method. Univariate and multivariate Cox proportional hazard regression analyses were carried out.

RESULTS:
Sixty patients in total were included. SA’s optimal cutoff value for survival analysis was 3.95 g/dL, according to the receiver operating characteristic (ROC) curve. Patients were categorized into two groups based on that value, 25 (41.7%) had low (≤3.95 g/dL) and 35 (58.3%) had high SA levels (>3.95 g/dL). The PFS rate for 18 months was 56.7%. Kaplan–Meier curves showed that patients with low SA had a significantly inferior PFS rate (28% vs. 77.1%, P < .001). The independent prognostic significance of SA was verified by multivariate analysis.

CONCLUSION:
Low baseline SA levels (≤3.95 g/dL) could be a simple and effective factor in predicting poor 18-month PFS in Syrian NHL patients. To verify our findings, more extensive research is advised.