bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermo-Rheological Structure of the Southern Section of the Tan-Lu Fault Zone and Surrounding Areas: Tectonic and Geodynamic Implications
Authors: Wu Jinhui , Wang Yibo , He Lijuan , Wang Zhuting , Hu Jie , Wang Yaqi , Hu Shengbiao 
Published: January 2025

Abstract
Research into the thermo-rheological structure of the lithosphere not only offers substantial constraints on the lithospheric thickness, geophysical characteristics, and tectonic evolution but also provides crucial insights into the causes of earthquakes and tectonic deformation. The southern section of the Tan-Lu Fault Zone, serving as an ancient plate boundary, divides the South China Block in the Lower Yangtze region and the North China Craton in the northern Anhui region. Studies on heat flow across the fault zone reveal significant lateral differences in thermal states on either side of the fault. However, the distribution pattern of heat flow lacks supportive evidence from thermal structure and rheological studies. In this research, we conducted detailed simulations of the thermo-rheological structure using two-dimensional seismic profiles that traverse the southern section of the Tan-Lu Fault Zone. The results indicate no significant anomalies in surface heat flow perpendicular to the fault zone. However, deep temperature anomalies are present. Additionally, the lithospheric rheological strength increases gradually from east to west, transitioning from the “jelly sandwich” model in the east to the “crème brûlée” model in the west, likely due to the dual control of lithospheric thermal structure and crustal compositional differences.
Timelapse Fluid Properties Analysis for Monitoring and Management of a Miscible Flood Operations in a Giant Carbonate Oil Field
Authors: Saduakassov B. , Azhigaliyeva A. , Bopiyev C. , Mussayev G. , Ghomian Y. 
Published: January 2025

Summary
Tengiz oil field has several decades of production history. Over the years since Tengizchevroil joint venture was formed, numerous PVT samples have been collected to describe fluid properties within the reservoir and identify any potential variations across the field. More than hundreds of reservoir oil samples have been collected at wellhead and downhole single-phase conditions covering all regions within the field. Our study indicates that there have been no significant measurable variations in original reservoir fluid across the field areally or vertically.
With the introduction of Sour Gas Injection (SGI) in the platform area in 2008, sample collection was more focused on this region. As injectant agent has elevated H2S content compared to original fluid, upon mixing resulting saturation pressure and GOR (gas oil ratio) are expected to increase. Studies reconfirm miscible process with indications of up to 50% sour gas mixture ratio from samples in the injection area. Periodic PVT sampling in SGI area ensured to be a reliable way to monitor SGI maturing process. Besides of standard compositional PVT analyses, fluid samples were taken in 2019 sampling campaign with the objective of capturing possible changes in fluid properties due to ongoing miscible sour gas flood and to conduct specialized studies such as Minimum Miscibility Pressure (MMP) and Asphaltene Onset Pressure (AOP) measurements.
Comparing fluid samples taken from the same well outside of SGI in 1997 and 2019 indicate no significant variations in original reservoir fluid.
The laboratory data was also cross-referenced with the measurements from multi-phase flow meters (MPFM) across the field. This helped to produce correlations between main fluid characteristics (e.g., GOR, H2S mole %, bubble point pressure, sour gas mixing ratio, etc.) from different sources. These correlations along with fluid modeling studies can be used to extrapolate our current understanding of fluid properties to potential changes in reservoir fluid helping to save costs and reduce frequency of future sampling operations.
This paper will summarize different PVT studies performed on Tengiz fluid and provide a holistic view of changes in the fluid properties at the different stages of field life; it should also serve as a guideline for understanding fluid properties in Tengiz.
Retarded DSB repair kinetics suggestive of augmented radiation sensitivity and genetic instability in Wiskott-Aldrich syndrome patients
Authors: Pathak Ranjana S. , Chaurasia Rajesh Kumar , Sapra B.K. , Gaikwad Pallavi , Bargir Umair , Madkaikar Manisha , Shirsath K.B. , Goel Anjana , Bhat N.N. , Khan Arshad 
Published: January 2025

Abstract

Wiskott-Aldrich Syndrome (WAS) is a rare X-linked recessive disorder characterized by microthrombocytopenia, eczema, combined immunodeficiency, and an increased risk of malignancies. Previous research has highlighted genomic instability in WAS patients; however, the specific dynamics of double-strand break (DSB) repair in these individuals are not fully understood. Phosphorylation of γH2AX serves as an early indicator of DSBs, while 53BP1 binds to damaged chromatin in a γH2AX-dependent manner, stabilizing DNA ends and facilitating repair and hence serves as a marker for assessing DNA repair kinetics. In this study, we investigated the kinetics of DSBs in WAS patients and their carrier mothers using markers such as γH2AX and 53BP1. To evaluate radiation sensitivity, lymphocytes from WAS patients were exposed to 2 Gy of gamma radiation, and repair kinetics were recorded over 24 hours. Immunofluorescence staining for γH2AX and 53BP1 was performed on both irradiated and non-irradiated lymphocytes from patients, carrier mothers, and healthy controls at various time points. Notably, WAS patients exhibited a significant increase in baseline levels of γH2AX and 53BP1 (16 to 24 times higher) compared to healthy controls. Post-radiation decay model revealed a significantly prolonged DSB repair rate in WAS patients, with a repair half-life 1.5 to 1.9 times longer than that of controls. Additionally, at 24 hours, WAS patients showed 37–39% and 33–43% excess γH2AX and 53BP1 foci per cell, respectively, indicating increased genomic instability and radiosensitivity. This study provides the first evidence of delayed repair kinetics in WAS patients, which may impact clinical decisions regarding radiation or genotoxic exposure during diagnosis and treatment.
Quantifying Service Sector Waste: Insights from the Spanish Economy
Authors: Rodríguez Mercedes , Camacho José A. 
Published: January 2025

Abstract

Global waste generation is projected to rise significantly in the coming decades, with high-income countries contributing disproportionately to per capita waste production. While the European Union’s Circular Economy Action Plans prioritize resource-intensive sectors, the service sector’s contributions to waste generation remain underexplored. This study offers a detailed assessment of waste generation in Spain, distinguishing between direct and indirect contributions as well as their domestic and foreign origins, with a particular focus on disaggregated data for service activities. By employing environmentally extended input-output (IO) modeling, this research reveals the significant indirect contributions of the service sector, driven by complex supply chain interactions. The findings underscore the critical need to integrate detailed service sector data into waste management strategies, offering actionable insights to enhance the design and implementation of circular economy policies. This study contributes valuable knowledge of the service sector’s role in waste generation and highlights key areas for future research aimed at fostering sustainable economic practices.
The Relation Between Sleep Quality, Suicidal Thoughts &amp; Job Efficacy Among Healthcare Workers in Public Hospitals of Kabul City
Authors: Sultani Abdul Ahad , Ayubi Bezhan , Sediqi Khwaja Zabihullah 
Published: January 2025

Abstract

Background: Sleep quality is an important factor in the health and well-being of healthcare workers. Poor sleep quality has been associated with a number of negative outcomes, including lower job efficacy and higher suicidal thoughts.
Objective: The purpose of this study was to investigate the relationship between sleep quality, suicidal thoughts and job efficacy in healthcare workers.
Methods: A correlational study was conducted with a sample of 130 healthcare workers employed in governmental hospitals in Kabul City, Afghanistan. Data were collected using the Pittsburgh Sleep Quality Index (PSQI), the Job Efficacy Scale, and the Beck Scale for Suicidal Ideation (BSSI).
Results: This study found that 60% of healthcare workers experience poor sleep quality, sleep quality and suicidal thoughts were interrelated but there was no significant correlation between job efficacy, suicidal thoughts and sleep quality. Poor sleep quality was associated with higher suicidal thoughts.
Conclusion: The findings of this study highlight the importance of addressing sleep problems in healthcare workers. Understanding sleep quality can inform healthcare policies and interventions aimed at improving sleep quality among this population. Highlighting the correlation between sleep quality and suicidal thoughts can lead to increased awareness and prompt the development of mental health support systems within healthcare settings. Future research should investigate the effectiveness of interventions to improve sleep quality in healthcare workers.
A Descriptive Correlational Study on the Impact of Educational Technology in Shaping the Level of Students' Self-efficacy During Physical Activities
Authors: Estopil Jhon Roy A. 
Published: January 2025

Abstract

The study investigated the significant correlation between educational technology standards in physical education and the physical activity self-efficacy of students. This research employed a quantitative research method using a descriptive correlational design. This study involved 303 respondents and utilized a stratified random sampling technique for data gathering, done electronically through email with a link to the Google form-made questionnaire sent to the respondents. Mean, and Pearson r were the statistical tools used to describe the significant level and correlation of the contrasts in this study. The results found a high descriptive level for the educational technology standards in physical education and a moderate descriptive level for physical activity self-efficacy. Finally, bivariate correlation analysis using “Pearson r Product Moment Correlation” was employed to determine the relationship between the variables. The correlation analysis involving educational technology standards and physical activity self-efficacy yielded an r-value = (0.259) with a probability value of p (<0.000), less than the alpha value = (0.05), and the decision on Ho was rejected. Thus, there is a piece of sufficient evidence to reject the null hypothesis of no meaningful relationship between variables. This means that there is a significance in the relationship between educational technology standards and physical activity self-efficacy in physical education classes.
Use and Implications of the Apgar score in Evaluating Resuscitation of
Newborns with Birth Asphyxia in Ghana
Authors: Ramasethu Jayashree , Narayanan Indira , Arhin Jeffery , Yeboah Rita , Insaidoo Genevieve , Mintah Eunice , Awutey Evans 
Published: January 2025

Abstract

Objective
To evaluate lack of impact of Helping Babies Breathe Program on neonatal mortality in four Ghana hospitals despite quality improvement measures.
Methods
Analyzed correlations between Apgar scores and outcome in newborns ≥ 34 weeks gestation who had birth asphyxia (BA, 1 minute Apgar score < 7) and severe BA (1 minute Apgar score ≤ 3).
Results
Among 12,702 live births, 18.9% had BA and 2.8% had severe BA. Among 2044 newborns with 1 minute Apgar score of 4–6, 16 (0.8%) died, compared to 15.6% mortality in 352 newborns with severe BA (p < 0.0001). In newborns with severe BA, the mortality rate was higher in those whose scores remained ≤ 3, than in those whose scores rose to 4–6 or more by 5 minutes (OR 19.93, 95% CI 9.4; 42.1;p < 0.0001).
Conclusions
The Apgar score is helpful in understanding where additional interventions may improve BA related neonatal mortality in low and middle income countries.
Bioaccumulation of heavy metals in benthic and nektonic tadpoles inhabiting impacted areas after the tailings dam rupture in Mariana, MG, Brazil
Authors: Ramos Juliana Conceição , de Santana Carolina , de Jesus Taíse Bomfim , Juncá Flora Acuña 
Published: January 2025

Abstract

The harmful effects of chemical contamination of the environment have motivated the search for tools for the assessment of environmental quality, including bioindicators. Here we evaluate the bioaccumulative potential of benthic and nektonic tadpoles occurring in areas affected by iron ore tailings. We analyzed the concentrations of Al, Ba, Cd, Cr, Cu, 34 Fe, Mn, Ni, Pb, Ti, V and Zn in the water, sediment, and in benthic tadpoles with intestine (BI) and surgically removed intestine (BR), and nektonic tadpoles with intestine (NI) and 36 removed intestine (NR). We collected tadpoles in seven sites directly affected by the tailings and in seven sites without direct contact with the tailings mud. There were no differences in concentrations of heavy metals between the sampling points for water and sediment. Benthic tadpoles (BI) from sites directly affected by the tailings showed higher concentrations of metals Al, Ba, Fe, Mn and Ti, than nektonic tadpoles (NI). On the other hand, NR showed higher concentrations of Cr, Al, Ni, Mn, Zn, Cu and Ti than BR. The highest concentration of metals BI may be linked to the association of the group with the metals adsorbed to the sediment, where there were the highest concentrations. The metals associated with NR are due to accumulation in different tissues of the body. In general, the concentrations of metals in the environment are reflected in the tadpoles’ tissues. Additionally, the differences between benthic and nektonic tadpoles show the movement of these metals along the trophic chain in this ecosystem.
Integrating AI-Driven Emotional Intelligence in Language Learning Platforms to Improve English Speaking Skills through Real-Time Adaptive Feedback
Authors: Tajik Aliakbar 
Published: January 2025

Abstract

This groundbreaking study introduces the first-ever integration of emotional intelligence (EI) with artificial intelligence in English-speaking instruction through an emotionally adaptive language learning system. Through a mixed-method design, the research examined this innovative approach’s impact on speaking proficiency among 40 high school students (aged 15-18) from Varamin County, Iran. The experimental group (n=20) engaged with the novel “Amazon Alexa-Speak” Speaking Assessment System, featuring AI-driven EI-based real-time feedback; in contrast, the control group (n=20) received conventional instruction over six sessions following a pretest to ensure group homogeneity. The study employed a concurrent mixed method design, collecting quantitative data through the “Amazon Alexa-Speak” Speaking Assessment System and the researcher-made perception questionnaire; qualitative data came from researcher-made classroom observation checklists and researcher-made semi-structured interviews (n=20), focusing on emotional state monitoring and anxiety reduction patterns. Statistical analyses revealed a significant positive correlation between EI and speaking performance (p < 0.05, η2 = 0.42), with the experimental group showing substantially enhanced proficiency (F(1,38) = 24.63, p < 0.05). The system’s emotional state detection algorithm demonstrated 94% accuracy in identifying and responding to learners’ affective states. This study presents a paradigm shift in language education technology by introducing the first system that simultaneously addresses cognitive and emotional aspects of language acquisition. The findings have significant implications for the global language learning market, particularly in addressing speaking anxiety and emotional barriers in language learning. This technology’s scalability and cross-cultural applicability make it a potentially transformative solution for language education worldwide, opening new avenues for emotionally intelligent educational technology development.
Enzyme Activity and Genetic Polymorphisms of Paraoxonase 1 in Patients With Type 2 Diabetes Mellitus: A Case-Control Study
Authors: Kocyigit Emine , Karadağ Makbule Gezmen , Akturk Mujde , Varis Ahmet 
Published: January 2025

Abstract

Paraoxonase-1 (PON1) plays a role in the prevention of lipid peroxidation and has been linked to type 2 diabetes mellitus, which is characterised by elevated oxidative stress. In this case-control study, 102 patients with T2DM and 102 healthy controls aged 30 to 60 were included. Anthropometric and body composition measurements of individuals were taken. Total antioxidant status (TAS), total oxidant status (TOS), PON1 activity, and metabolic parameters were analyzed in serum samples of all participants. These samples were genotyped by TaqMan. Dietary antioxidant capacity (DTAC) of individuals was assessed using 3-day food records. No statistically significant difference was observed between groups in the alleles and the genotype frequencies of SNPs. PON1 activity was significantly higher in controls compared to patients with T2DM. Furthermore, RR and LL genotypes were significantly associated with higher PON1 activity. In T2DM patients, HbA1c, fasting blood sugar (FBG), and LDL-cholesterol (LDL-c) were more elevated in all genotypes of the Q192R gene; triglyceride (TG) was higher in QQ and QR genotypes of the gene; TAS was higher in the RR genotype of the gene; and DTAC was lower in the QQ genotype of the gene compared to their respective controls. In controls, LDL-c and TG were lower in all genotypes of the L55M gene; HbA1c and FBG were lower in the LL and LM genotypes of the gene; total body fat was more down in MM genotype, but total body water, fat-free mass, and MET score were higher in MM genotype of the gene compared to their respective controls. Multiple linear regression analyses showed that several factors associated with the activity of PON1 were the PON1 genotypes, HDL-c, TAS, and TOS. Our study supports that the PON1 polymorphisms are associated with PON1 activity, glucose, and lipid metabolism parameters in patients with T2DM.
The Expression of Pax6 Genes in an Eyeless Arachnid Suggests Their Ancestral Role in Arachnid Head Development
Authors: Joyce Isabella , Barnett Austen A. 
Published: January 2025

Abstract

Background: Many animal lineages utilize Pax6 transcription factors during eye development. Within Arthropoda, evidence suggests that Pax6genes are necessary for the specification of eyes in myriapods, crustaceans, and insects. However, recent data have argued that Pax6 genes lack a role in the development of the eyes in Chelicerata (=arachnids, horseshoe crabs, and sea spiders). An alternative hypothesis argues that the absence of Pax6 expression in developing chelicerate eyes could be explained by an earlier role for these genes in patterning eye precursor cells. The arachnid mite Archegozetes longisetosus lacks eyes, however it retains two Pax6 paralogs in its genome. By leveraging these aspects of A. longisetosus, we tested the hypothesis that ancestrally chelicerates did not use Pax6 genes to pattern their eyes but rather used them to pattern the central nervous system. We reasoned that if we observed comparable expression patterns of Pax6 genes in A. longisetosusin comparison to those in arachnids that have retained eyes, then this would support the hypothesis that Pax6genes were not ancestrally used for eye specification in chelicerates.
Results: We followed the expression of canonical arthropod retinal determination genes to confirm that A. longisetosus does not develop vestigial eyes. We found that the expression of the Pax6 paralogs was consistent with their roles in the development of the ocular region and central nervous system. By co-staining for these genes simultaneously with the conserved head patterning gene orthodenticle, we also observed early expression patterns of these genes in the protocerebrum of early A. longisetosus embryos that are comparable to those arachnids with embryonic eyes.
Conclusions: Our data provide support for the hypothesis that Pax6 genes were not ancestrally used to pattern chelicerate eyes. The expression patterns of Pax6 genes in A. longisetosus were comparable to those of other arachnids that have eyes. This suggests that the retention of Pax6genes in A. longisetosus is due to their ancestral, non-eye patterning roles. Further supporting this hypothesis is our observation that A. longisetosusdoes not pattern vestigial eyes. Lastly, our data suggests that the Pax6 genes, with orthodenticle, acted to specify the ancestral arachnid protocerebrum.
Clinical Oral Investigations Biological and Physicochemical Characterization of Nanoemulsions Containing Morin and its Derivatives for Endodontic Purposes
Authors: Pereira Jesse Augusto , Rios Rafael Araújo , Duarte Jonatas Lobato , Moraes Graciele Ribeiro , Ramos Ana Paula , Guiotti Aimée Maria , Kishen Anil , Regasini Luís Octavio , Chorilli Marlus , Duque Cristiane 
Published: January 2025

Abstract

Objectives
Considering the lack of medications with a wide range of therapeutic effects for the endodontic treatment of immature teeth, this study aimed at synthesizing two morin (Mo) derivatives and testing their cytotoxicity and effect on multispecies biofilm in solution and loaded in nanoemulsions (NE).
Material and methods
Minimum inhibitory and bactericidal concentration (MIC/MBC) of Mo, penta-acetylated Mo (Ac-Mo), Mo complexed with strontium (Sr-Mo) and control chlorhexidine (CHX) were determined against some oral bacteria. NE were physiochemically characterized by analysis of particle size, polydispersity index and zeta potential. NE containing Mo, its derivatives and CHX were evaluated against multispecies biofilms by bacterial counts, scanning electron microscopy and confocal microscopy. The cytotoxicity of the compounds and NE was also determined in fibroblasts using resazurin assays. The data were statistically evaluated (p < 0.05).
Results
All compounds presented bactericidal action against all bacteria tested (MIC/MBC from 0.125 to 1 mg/mL). Metabolic activity of fibroblasts was higher than 70% after treatment with compounds at 0.25mg/mL or lower. NE showed good droplet size distribution in nanoscale and stability. The highest bacterial reduction in multispecies biofilms was observed in NE + Ac-Mo, followed by NE + Mo, CHX and NE + Sr-Mo groups. All NE diluted at 12.5% did not affect fibroblast metabolism after 24h of treatment.
Conclusions
Morin and its derivatives, either alone or loaded in nanoemulsions, were effective against oral bacteria and showed cytocompatibility at lower concentrations.
Clinical Relevance:
Nanoemulsion containing penta-acetylated morin could be an alternative intracanal medication for reducing residual bacteria between clinical appointments in regenerative endodontic approaches for immature teeth.