bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of educational intervention on the quality of life of women suffering from pregnancy-related nausea and vomiting: A systematic review
Authors: Piri Mahsa , Maleki Azam , Saed Omid 
Published: October 2023

Abstract

Background
Various interventions have been implemented to improve the quality of life for women suffering from pregnancy-related nausea and vomiting.
Objective
The present study aimed to determine the influence of educational interventions on improving the quality of life of women suffering from pregnancy-related nausea and vomiting as a systematic review.
Methods
The current Systematic Review followed the standard PRISMA checklist guideline. The English electronic databases were used to identify relevant studies published until 14 August 2023. The search strategies employed were based on Mesh browser keywords. and free-text words. The study risk of bias was evaluated using the Cochrane Collaboration's tool for assessing the risk of bias tools and publication bias was evaluated using a funnel plot and Begg and Egger tests. The heterogeneity of the studies was evaluated using I2 and tau-squared tests. Data were analyzed using the RevMan 5 software. Results of the random-effects meta-analysis were presented using the standard mean difference, along with a 95% confidence interval.
Results
Out of the 7 RCT studies with a total of 946 subjects included in the review, five studies reported a significant result, indicating that the interventions had a statistically significant effect on the quality of life of women suffering pregnancy-related nausea and vomiting and in two studies did not have a significant result. A subgroup analysis was done based on the type of quality-of-life measurements.
The pooled standardized mean difference (SMD) of four articles (NVPQOL) with a total of 335 subjects was -2.91, and (CI) of -4.72 to -1.11, p-value= 0.002, I2=97.2%). The pooled standardized mean difference (SMD) of three articles (SF36) with a total of 611 subjects was -0.05, and (CI) of -0.23 to -0.12, p-value = 0.550, I2=10%.
Conclusion
The overall results of the analysis indicated that educational intervention had a small positive impact on the quality of life of women experiencing pregnancy-related nausea and vomiting. However, to draw a better conclusion, it is recommended to conduct further studies with larger sample sizes and longer follow-up periods.
The relationship between preoperative blood pressure during anesthetic examinations and pre-intubation blood pressure
Authors: Koibuchi Ikuya , Kadoi Yuji , Asou Chizu , Saito Shigeru 
Published: October 2023

Abstract
Background
There have been few reports showing the relationship between blood pressure (BP) measured at clinics preoperatively and BP measured immediately before intubation. The purpose of this study was to examine the relationship between BP measured at different times and settings preoperatively and BP measured before intubation.
Methods
A total of 182 patients who underwent general anesthesia between March 2021 and April 2022 in a university hospital were examined. In addition to self-reported BP asked on an anesthetic examination sheet completed by each patient, BPs were measured three times, before, during, and after preoperative examination by the anesthesiologist. The derived parameter was compared with BP measured immediately before intubation at the time of general anesthesia induction.
Results
The systolic BP in the intra-examination period had the most significant correlation with pre-intubation systolic BP (r = 0.5230, p < 0.0001, 95% CI = 0.4050 to 0.6238). On Bland-Altman analysis, the intra-examination systolic BP seemed to be similar and showed better agreement with pre-intubation systolic BP than other measured BPs, with a mean bias of 2.2 mmHg and the narrowest 95% limits of agreement (-33.7 to + 38.1 mmHg).
Conclusions
The preoperative systolic BP value measured during the examination by the anesthesiologist was found to be closely related to pre-intubation systolic BP measured in the operating room. Higher BP during the preoperative examination may be a result of anxiety-induced stress or white-coat hypertension. Measuring BP during the anesthesiologist’s examination may be useful for predicting hypertension in the pre-intubation period.
A combination of human activity and climate drives forest fire occurrence in Central Europe: case of the Czech Republic
Authors: Berčák Roman , Holuša Jaroslav , Trombik Jiří , Resnerová Karolina , Hlásny Tomáš 
Published: October 2023

Abstract
Background
Central Europe is not a typical wildfire region; however, an increasingly warm and dry climate and model-based projections indicate that the number of forest fires are increasing. This study provides new insights into the drivers of forest fire occurrence in the Czech Republic, during the period 2006 to 2015, by focusing on climate, land cover, and human activity factors.
Results
The average annual number of forest fires during the study period was 728, with a median burned area of 0.01 ha. Forest fire incidence showed distinct spring (April) and summer (July to August) peaks,with median burned areas of 0.04 ha and 0.005 ha, respectively. Relationships between the predictors (climate data, forest-related data, socioeconomic data, and landscape-context data) and the number of forest fires in individual municipality districts were analyzed using Generalized Additive Models (GAM) on three time scales (annually, monthly, and during the summer season). The constructed GAMs explained 48.7 and 53.8% of forest firevariability when fire occurrence was analyzedon a monthly scale and during thesummer season, respectively. On an annual scale, the models explained 71.4% of the observed forest fire variability. The number of forest fires was related to the number of residents and overnight tourists in the area. The effect of climate was manifested on monthly and summer season scales only, with warmer and drier conditions associated with higher forest fire frequency. A higher proportion of conifers and the length of the wildland–urban interface were also positively associated with forest fire occurrence.
Conclusions
Forest fire occurrence was influenced by a combination of climatic, forest-related, and social activity factors. The effect of climate was most pronounced on a monthly scale, corresponding with the presence of two distinct seasonal peaks of forest fire occurrence. The significant effect of factors related to human activity suggests that measures to increasepublic awareness about fire risk and targeted activity regulation are essential in controlling the risk of fire occurrence in Central Europe. An increasing frequency of fire-conducive weather, forest structure transformations due to excessive tree mortality, and changing patterns of human activity on the landscape require permanent monitoring and assessment of possible shifts of forest fire risk.
Comparison of Light Transmittance and Color Changes between Polyurethane and Copolyester Retainer Materials after Staining and Destaining.
Authors: Viana Grace , Virji Insia , Susarchick Laurie , Allareddy Veerasathpurush , Lown Sullivan , Gruber Max , Lukic Henry , Megremis Spiro , Atsawasuwan Phimon 
Published: October 2023

Abstract
Background
Retainers are the only effective approach to prevent orthodontic relapse. The aim of this study was to compare the changes in color and light-transmittance of rough and smooth thermoformed polyurethane and copolymer retainer samples after staining in different solutions and destaining with different approaches.
Methods
Four hundred copolyester (Essix® ACE) and 400 polyurethane (Zendura®) samples with different surface textures, smooth and rough, were stained in 4 different solutions (n = 100 per solution) over 28 days. Each of the four groups of 100 stained samples of each material was subdivided into 5 groups of 20 samples and subjected to different destaining solutions. Light transmittance and color changes were evaluated using a spectrometer and a spectrophotometer. Mean differences were compared using appropriate statistical tests at P = 0.05.
Results
No significant differences in light transmittance were found between both untreated materials. Both materials were stained in a similar fashion and showed no significant differences between two materials. Coffee and tea stained both materials more significantly than wine, but there was a significant difference of changes of color and light transmittance between rough and smooth surfaces during the destaining in coffee- and tea-stained samples of copolyester material. All destaining solutions were effective at removing all stains on the samples. The surface roughness of the material plays a significant role in the ability of the materials to be destained, demonstrating a more significant greater effect on cleaning rough samples for improvements in light-transmittance and greater changes in color.
Conclusions
This study concluded that the surface of materials plays a significant role in the material destaining and staining. In addition, the different polymer used for retainer fabrication exhibited different responses during the destaining process depending on types of stains.
The clinicopathological and prognostic value of CLDN18.2 expression in gastric cancer: A meta-analysis
Authors: Ma Luyao , Qin Xiaobing , Yu Aoyang , Liu Haonan , Gao Ying , Ma Xiao , Pan Di , Wu Zichen , Chen Zihan , Zhang Xinran , Han Zhengxiang 
Published: October 2023

Abstract
Objective
The tight junction protein Claudin-18.2 is a potential target for gastric cancer therapy. Given the divergent results of multiple published studies on the expression of CLDN18.2, this meta-analysis aimed to assess its clinicopathologic and prognostic significance in gastric cancer.
Method
We identified 14 eligible studies in the PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wangfangdate, and CBM databases from their inception to August 2023 and performed meta-analyses using STATA version 15.0.
Result
14 eligible studies including 2908 patients were subjected to analysis. High CLDN18.2 expression was associated with a poorer OS (HR = 1.171, 95% CI: 1.035–1.325, p = 0.012), as well as a poorer PFS (HR = 1.307, 95% CI: 1.041–1.642, p = 0.021). Furthermore, CLDN18.2 expression in gastric cancer was apparently correlated with EBV status (OR = 3.082, 95% CI: 1.024-9.20, p = 0.045), ECOG score (OR = 1.750, 95% CI: 1.029–2.977, p = 0.039), HER2 expression (OR = 0.650, 95% CI: 0.455–0.929, p = 0.018), grade level (OR = 0.504, 95% CI = 0.299–0.849, p = 0.01), presence of liver metastases (OR = 0.586, 95% CI: 0.363–0.945, p = 0.029), PD-L1 expression (OR = 1.684, 95% CI: 1.132–2.506, p = 0.01), and TNM stage (OR = 2.028, 95% CI: 1.056–3.896, p = 0.034).
Conclusion
Elevated expression of CLDN18.2 has been observed to be correlated with poor OS and PFS in cases of gastric cancer. This finding suggests that CLDN18.2 is a valuable prognostic marker in addition to being a therapeutic target in gastric cancer.
The sexed retina: a combined single-cell and bulk RNA sequencing analysis of healthy aging human retina
Authors: Tan Qiang , Liu Hongling , Bian Baishijiao , Liu Yong 
Published: October 2023

Abstract
Background
The human retina is subjected to age-related neurodegenerative diseases like other CNS tissues, but little attention is paid to sex. Previous studies have exhibited divergent sexual responses to aging, but how gene expression profiles differ between males and females and how these differences could be associated with age-related retinal diseases remains elusive. As such, we performed a combined analysis of single-cell RNA (scRNA) and bulk RNA sequencing of the healthy aged retina of females and males.
Results:
We discovered significant differences in transcriptome profiles in the macular and peripheral retina regions between the two sexes. Despite all major retinal cell types being identified in female and male healthy aging retinas, sex specificity is prominent in gene expression and retinal disease-related genes. Cell-to-cell communication analysis revealed an elevated CCL7/TGFB1/VEGFA-associated interaction in the glial cells of the female retina. Finally, we identified MC1 as a subpopulation of microglia responsible for the susceptibility to immune inflammation in the macular retina of females. In males, the differentially expressed genes of retinal glial cells were associated with regeneration and protection.
Conclusions:
This study provides a comprehensive comparison between females and males and found a profound dissimilarity between sexes in healthy aging human retinas, suggesting that age-related changes in the retina are sex-related and that the female retina is more susceptible to neuroinflammation. This study provides valuable insights into identifying therapeutic and prevention targets in retinal aging diseases by considering sex as an important factor.
Disseminated multi-organ aspergillosis with acute cerebral infarction in a patient with myelodysplastic syndrome. A case report.
Authors: Wang Zhao , Wang Xiaofang , Zhang Huan , Xiao Xia , Lv Hairong , Zhao Minfeng 
Published: October 2023

Abstract
Background:
Central nervous system invasive aspergillosis (CNS-IA) is a relatively uncommon but frequently fatal infectious disease, especially in immunodeficiency patients. The clinical manifestations of CNS-IA are diverse; however, the cases with blindness and cerebrovascular events as the main clinical manifestations are extremely rare. We present, herein, the case of a patient with myelodysplastic syndrome, who was diagnosed with disseminated aspergillosis involving the CNS, lungs, and eyeballs, followed by a fatal basal ganglia infarction as the major cause of death. This report reveals the diversity of clinical manifestations in the patients with CNS-IA, and essence of a dreadful infectious disease.
Case presentation:
A 48-year-old male patient with myelodysplastic syndrome was admitted to the hospital with progressive visual extinction in the left eye and recurrent fever. Imaging examination showed multiple intracranial and pulmonary lesions. The metagenomic next-generation sequencing (mNGS) test of the patient’s peripheral blood and cerebrospinal fluid both positive for Aspergillus nidulans. Endophthalmitis was diagnosed based on the patient’s clinical symptoms and mass-like echogenicity observed in the atrium on ophthalmologic ultrasound. Combined antifungal therapy (voriconazole + caspofungin) was provided to the patient, followed by significant symptom relief and imaging improvement at the time of one week post treatment. However, after the continued antifungal treatment for another four days, the patient suddenly suffered from new-onset acute infarcts in the left basal ganglia, and died five days later.
Conclusions:
CNS-IA is an infectious disease with diverse clinical manifestations and high mortality. Due to the angio-invasive capacity of Aspergillus, multiple organ involvement, especially more severe cerebrovascular events may occur in patients with CNS-IA, which is worth clinicians to be alert to this complication.
Blockchain-enabled Crafts Supply Chain for Rural Handicraft Artisans: An Implementation Approach
Authors: Basak Jayanta , Saha Advaita , Bhaumik Parama , Roy Siuli 
Published: October 2023

Abstract
The rural handicrafts industry is a highly fragmented industry with many small-scale businesses. Despite its cultural and economic importance, this industry encounters challenges like intermediary exploitation, restricted market entry, and lack of a credible product authentication system, making it susceptible to competition from cheaper machine-made alternatives. It can lead to loss of sales and reputational damage endangering both the artisans' livelihoods and the craft's sustainability. To address these challenges, establishing end-to-end visibility within the rural handicrafts supply chain offers enhanced transparency, traceability, and authentication. This fosters trust among the various participants in the supply chain. However, ensuring the integrity of the supply chain data is essential, necessitating a mechanism to secure production process information, verify product and artisan authenticity, and enable transparent transactions. This paper proposes a blockchain-enabled crafts supply chain for rural artisans and presents an innovative implementation approach using the real data (artisan and product profiles) from rural kantha artisans in Birbhum district, West Bengal. By leveraging the decentralized, immutable, and transparent nature of blockchain, our approach provides a practical framework that could be adapted to other similar contexts.
Effect of immune-modulating metronomic capecitabine as an adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma
Authors: He Qianyong , Luo Xiuling , Liu Lina , Zhao Chaofen , Li Zhuoling , Jin Feng 
Published: October 2023

Abstract

Introduction Metronomic capecitabine used as an adjuvant therapy improves survival in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). This therapeutic approach may also contribute to improved immune function, consequently enhancing overall therapeutic efficacy.
Aim We aimed to evaluate the effect of metronomic capecitabineas an adjuvant therapy on immune function and survival in cases of LA-NPC.
Subjects and methods Enrolled in the study were 28 patients with LA-NPC, who were equally assigned to two groups of 14 each: experimental and control group. The experimental group received induction chemotherapy + concurrent chemotherapy + adjuvant chemotherapy as well as oral capecitabine at a dose of 650 mg/m² of body surface area twice daily for 1 year, with the option to discontinue in case of intolerance. The control group did not receive additional chemotherapy or targeted drugs after the induction chemotherapy + concurrent chemoradiotherapy; however, they were followed up regularly. Immune function changes and survival were compared between the two groups.
Results The median follow-up time was 43.5 months. The experimental group exhibited higher levels of CD8+, CD28+, CD8+, and activated CD8+ cells 1 year after adjuvant chemotherapy compared to the control group (P < 0.05). The CD4/CD8 ratio and proportion of monocyte-derived dendritic cells of the experimental group were also higher than those of the control group, but the difference was not statistically significant (P ≥ 0.05). The comparisons of overall survival, local-regional recurrence-free survival, progression-free survival, and distant metastasis-free survival between the experimental group and the control group showed percentages of 92.9% vs. 78.6%, 92.9% vs. 92.9%, 78.6% vs. 71.4%, and 85.7% vs. 78.6%, respectively, but these differences were not significant (P > 0.05).
Conclusion It was observed that metronomic capecitabine chemotherapy induces an immunomodulatory effect in LA-NPC.
Trial registration: NCT02958111, date of registration 04-11-2016.
Impact of autonomic symptoms on the clinical course of Parkinson’s disease
Authors: Fujita Hiroaki , Ogaki Keitaro , Shiina Tomohiko , Sakuramoto Hirotaka , Nozawa Narihiro , Suzuki Keisuke 
Published: October 2023

Abstract

Purpose
Autonomic dysfunction is a candidate marker for predicting clinical outcomes in patients with Parkinson's disease (PD), butthe impact of the severity of autonomic symptoms on the subsequent progression of PD has not been fully elucidated. The purpose of this study was to investigate the impact of the severity of autonomic symptoms on the clinical prognosis of patients with PD.
Methods
Seventy-four consecutive patients with PD were classified into two groups, defined by severe or mild autonomic symptoms, using the Scales for Outcomes in PD–autonomic dysfunction (SCOPA-AUT). The time to endpoints (discontinuation of visits because of hospital admission, death, or institutionalization) was evaluated retrospectively four to six years after the initial evaluation and compared between the two groups. We also investigated factors associated with poor prognosis.
Results
The patients with high SCOPA-AUT scores reached the endpoints in a shorter time than those with low SCOPA-AUT scores (median time, 1452 days vs. 1699 days; P=0.006). The proportion of patients who were admitted or died was significantly higher among the patients with high SCOPA-AUT scores than among those with low SCOPA-AUT scores (43.9% vs. 12.1%, P =0.003). In the Cox survival analysis, high SCOPA-AUT (hazard ratio, 3.646; 95% CI, 1.143-11.633; p = 0.029) and Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III (hazard ratio, 1.036; 95% CI, 1.005-1.069; p = 0.024) scores were associated with faster progression.
Conclusions
The clinical course of PD was poor when autonomic symptoms were severe.
Research on the Prediction of Mine Water Inrush Disasters Based on Multi-Factor Spatial Game Reconstruction
Authors: Zheng Qiushuang , Wang Changfeng , Zhu Zhenhao 
Published: October 2023

Abstract
Water damage in mines pose a widespread challenge in the coal mining industry. Gaining a comprehensive understanding of the multi-factor spatial catastrophe evolution mechanism and process of floor water inrush is crucial, which will enable the achievement of dynamic, quantitative, and precise early warning systems. It holds significant theoretical guidance for implementing effective water prevention and control measures in coal mines.This study focuses on the issue of water inrush in the coal seam floor, specifically in the context of Pengzhuang Coal Mine. By utilizing a small sample of non-linear characteristics derived from drilling geological data, we adopt a multifactor spatial perspective that considers geological structure and hydrogeological conditions. In light of this, we propose a quantitative risk prediction model that integrates the coupled theoretical analysis, statistical analysis, and machine learning simulation methods.Firstly, the utilization of a quantification approach employing a triangular fuzzy number allows for the representation of a comparative matrix based on empirical values. Simultaneously, the networked risk transmission effect of underlying control risk factors is taken into consideration. The application of Principal Component Analysis (PCA) optimizes the entropy weight method, effectively reducing the interference caused by multifactor correlation. By employing game theory, the subjective and objective weight proportions of the control factors are reasonably allocated, thereby establishing a vulnerability index model based on a comprehensive weighting of subjective and objective factors.Secondly, the WOA-RF-GIS approach is employed to comprehensively explore the interconnectedness of water diversion channel data. Collaborative Kriging interpolation is utilized to enhance the dimensionality of the data and facilitate spatial information processing.Lastly, the representation of risk is coupled with necessary and sufficient condition layers, enabling the qualitative visualization of quantitative results. This approach aims to accurately predict disaster risk with limited sample data, ultimately achieving the goal of precise risk assessment.The research findings demonstrate that the reconstructed optimization model based on multi-factor spatial game theory exhibits high precision and generalization capability. This model effectively unveils the non-linear dynamic processes associated with floor water inrush, which are influenced by multiple factors, characterized by limited data volume, and governed by complex formation mechanisms. The identification of high-risk areas for water inrush is achieved with remarkable accuracy, providing invaluable technical support for the formulation of targeted water prevention and control measures. Consequently, this research proactively ensures the safety of coal mining operations.