bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone histology supports gregarious behavior and an early ontogenetic stage to Decuriasuchus quartacolonia (Pseudosuchia: Loricata) from the Middle‐Late Triassic of Brazil
Authors: de Farias Brodsky Dantas Macedo , Desojo Julia Brenda , Cerda Ignacio Alejandro , Ribeiro Ana Maria , Ferigolo Jorge , Carlisbino Thiago , Schultz Cesar Leandro , Mastrantonio Bianca Martins , Soares Marina Bento 
Published: December 2023

AbstractDecuriasuchus quartacolonia is a middle‐sized basal “rauisuchian” (Pseudosuchia, Loricata) from the Triassic beds of Brazil, whose original description was based on 10 specimens of equivalent size found in aggregation. In this contribution, we explore the osteohistology of its appendicular bones and a rib, aiming to infer growth patterns and ontogeny. In all analyzed bones (except in the rib) from three individuals, we found fibrolamellar bone (FLB) throughout the cortices, a pattern shared with other histologically sampled basal loricatans. We found evidence that suggests an early ontogenetic stage for all studied specimens: absence of secondary osteons, lack of transition from an inner highly vascularized FLB matrix to a poor vascularized parallel‐fibred bone, one line of arrested growth, open vascular canals in the external surface of the cortex and absence of an external fundamental system. In addition, we observed that the neurocentral sutures in the caudal to cervical vertebrae of the holotype are unfused, strongly suggesting that these individuals were not skeletally mature, as had been previously assumed. In addition, our data support the prior hypothesis that Decuriasuchus is the oldest‐known archosaur to show evidence of gregarious behavior and adds a probable cause of this as a strategy to obtain food and avoid predation until becoming independent as adults. Furthermore, our results open the possibility that Decuriasuchus may represent an earlier growth stage of the larger Prestosuchus chiniquensis, with two specimens recovered from the same stratigraphic level and paleontological site. Since the adult form of Decuriasuchus remains unknown, a deeper anatomical study is needed to discuss the validity of the species. This study case exemplifies the importance of paleohistology as an essential complementary tool to describe a new morphospecies in vertebrate paleontology.
An unusual non‐hematopoietic bone marrow finding
Authors: Altahan Rahaf , Alanazi Mohammed Lafi , Alharbi Mohammed Abdulaziz , Almalki Salman , Alswayyed Aziza , Alsuhaibani Laila 
Published: December 2023

Key Clinical MessageWe present an interesting case that showed a non‐hematopoietic structure embedded in the bone marrow biopsy. Given the clinical and morphological difficulties, it was challenging to identify this artifact's nature. Publishing this case would familiarize pathologists with this artifact and save additional testing and delays in reporting.
Intravenous methadone in the management of acute postoperative pain in a chronic cancer pain patient: A case report and review of the literature
Authors: Le Khang Duy Ricky , Hua Jean 
Published: December 2023

Key Clinical MessageThe current landscape of literature highlights that there is insufficient well‐powered and robust evidence to support the integration of intravenous methadone into current guidelines and frameworks in supporting the pain management of cancer patient with complex pain syndromes. However, there is preliminary evidence, both from the literature as well as this case study that highlights intravenous methadone may be efficaciously and safety used for the management of postoperative pain in cancer patients with chronic pain undergoing operative management. Further research is required to fully elucidate key considerations of integrating this medication into clinical practice including consideration into dosing, opioid conversion, tolerance, and safety.AbstractMethadone is a broad‐spectrum analgesic with long duration of effect. Its multimodal mechanism of action, such as through effects on mu‐opioid receptor and presynaptic N‐methyl‐D‐aspartate receptors, has led to its current use in the management of opioid dependence in the community and in palliative care. These properties however make methadone appealing in the management of postoperative pain, particularly for patients with complex analgesic requirements. We report on an interesting case whereby intravenous methadone was effectively used for postoperative analgesia in a 56‐year‐old female with complex chronic pain secondary to a mucinous pelvic neoplasm of unclear primary who underwent palliative resection. Further, we review the literature surrounding usage of methadone in this setting to understand current challenges and barriers to implementation of methadone as an analgesia option for chronic pain patients following surgery. To do this, a case report and literature review was conducted in accordance to the CARE case report guidelines. The patient provided written consent for the de‐identification and use of their medical information and data for the generation and publication of this case report. Our case report and literature review demonstrate there remains significant heterogeneity, unfamiliarity, and scarce use of intravenous methadone in the perioperative and postoperative space in the management of patients with complex pain regimens such as chronic cancer pain patients. Despite this, our case report and literature review highlight as a broad analgesic, intravenous methadone warrants consideration following more rigorous research and development of safe use guidelines into its use for this purpose.
Modelling High‐Temperature Electrochemical Cells: An Engineering Perspective
Authors: Murmura Maria Anna 
Published: December 2023

AbstractHigh‐temperature electrochemical cells have received increasing interest in the past years as important elements in an energy transition scenario. Their employment in power‐to‐gas or gas‐to‐power systems naturally requires an accurate design that takes into account the effect of operating conditions and geometries on both the performance of the cells themselves and their integration with other units. To this end, it is important to develop flexible yet comprehensive models for their description and to identify performance parameters that allow a concise assessment of their efficiency. The aim of the present work is to identify the limitations – in terms of applicability and consistency – of the mathematical models developed to date to describe high‐temperature electrochemical cells, as well as the key characteristics that they should possess. A brief review of literature in this field is then reported, to identify the research areas that still need to be explored.
Alkynylation of Aldehydes Initiated by Cathodic Reduction
Authors: Sato Eisuke , Fujii Mayu , Mitsudo Koichi , Suga Seiji 
Published: December 2023

AbstractAlkynylation of aldehydes initiated by cathodic reduction was performed. The cathodic alkynylation required only a semi‐catalytic amount of electricity to consume the starting material completely. Cyclic voltammetry and some control experiments suggest that the electron‐generated base derived from the cathodic reduction of benzaldehyde promotes alkynylation.
Single‐molecule Conductance and Electrochemical Measurements of Electron Transfer in β‐strand Peptides
Authors: Mo Wenjing , Horsley John R. , Li Xiaohui , Sheng Shiqi , Jong Bianca , Abell Andrew D. , Hong Wenjing , Yu Jingxian 
Published: December 2023

AbstractA series of β‐strand peptides comprising redox‐active amino acids in the P2 position were synthesized to investigate the effects of electron‐rich side chains on charge transfer and possible coupling interactions between side chains. Electrochemical results indicated a direct link between aromaticity of the side chains and electron transfer rate constants, while single‐molecule conductance studies supported the ability of the electron‐rich side chains to behave as ‘stepping stones’ to facilitate electron transfer through the peptides. Additional electrochemical analysis of the analogue containing D‐Tyr in the P2 position was undertaken at various pH levels and revealed intramolecular coupling interaction between the side chains, providing further insights on proton coupled electron transfer (PCET). These findings progress the established fundamental knowledge of charge transfer kinetics and explore new pathways for advancement in the architecture of molecular‐based electronic components and devices.
Conformer aggregates exhibit dual wavelength emissions on chiral binaphthyl‐based triphenylethylenes and acetone detection
Authors: Zhang Qing , Meng Xin , Qu Jun , Zhao Fapeng , Liao Xiaoming , Li Zan , He Yuanchun , Zhang Xiaoxiang , Cao Ziping 
Published: December 2023

AbstractThe study on structure‐property relationship has been a significant focus in the field of organic molecular luminescence. In the present work, three chiral binaphthyl‐based triphenylethylene (HTPE) derivatives were prepared through condensation reactions. Despite their similar structures, these compounds exhibited distinct luminescent properties. Diphenylmethane‐derived HTPE displayed dual‐state emissions, characterized by dual‐wavelength emissions which were insensitive to the polarity of solvents. The dual emissions in solution state could be attributed to the different locally excited (LE) excitons. However, upon aggregation, two stable conformers were generated, probably leading to different emission peaks. In contrast, dibenzocycloheptadiene‐derived HTPE aggregates showed only a single emission peak. Surprisingly, fluorene‐derived HTPE exhibited obvious luminescence in neither solution nor aggregate states due to inherent π‐π interactions. These conclusions were substantiated by X‐ray analysis, spectroscopic analysis, and theory calculations. Application studies demonstrated that fluorescence on/off switches could be achieved through exposure to acetone. More importantly, trace amounts of acetone could be detected using luminescent materials in both organic and aqueous phases with a detection limit of 0.08 %. Thus, this work not only presents a strategy for designing chiral triphenylethylene fluorophores but also provides valuable information for dual wavelength emissions resulting from two stable conformations.
Molecular Accessibility and Diffusion of Resorufin in Zeolite Crystals
Authors: Maris J. J. Erik , Parker Luke A. , Stanciakova Katarina , Nikolopoulos Nikolaos , Berendsen Koen M. H. , van Blaaderen Alfons , Meirer Florian , Rabouw Freddy T. , Weckhuysen Bert M. 
Published: December 2023

AbstractInvited for the cover of this issue is the group of Professor Bert Weckhuysen at Utrecht University. The image depicts the change in fluorescence color of a resorufin dye molecule when it is protonated and confined inside the micropores of zeolite‐β. Read the full text of the article at 10.1002/chem.202302553.
Calamitic Liquid Crystals for Reversible Light‐Modulated Phase Regulation Based on Arylazopyrazole Photoswitches
Authors: Trân Hoàn Quân , Kawano Shinichiro , Thielemann Rebecca E. , Tanaka Kentaro , Ravoo Bart Jan 
Published: December 2023

AbstractInvited for the cover of this issue are the groups of Kentaro Tanaka at Nagoya University and Bart Jan Ravoo at the University of Münster. The image depicts the photoisomerization of a mesogen upon irradiation with different wavelengths of light. Read the full text of the article at 10.1002/chem.202302958.
A secondary‐side semi‐active series resonant converter employing hybrid modulation scheme for on‐board chargers
Authors: Liu Hongjing , Tang Yu , Zhao Baolin , Yao Fang , Jia Guanlong 
Published: December 2023

AbstractThis paper proposes a secondary‐side semi‐active series resonant converter with hybrid control. Compared with the traditional series resonant converter (SRC), the converter only replaces two diodes with metal oxide semiconductor field effect transistors (MOSFETs) on the secondary side of the transformer, without adding any auxiliary components. By employing hybrid modulation scheme, the proposed converter can achieve a wide output voltage range in a narrow switching frequency range with high efficiency and has excellent soft‐switching performance. Due to the large magnetizing inductor and narrow switching frequency range, the proposed converter can achieve energy delivery with high efficiency and high power density. This paper provides a detailed introduction to the working principle, circuit characteristics, and design process of the converter. Finally, a 3.3 kW SiC‐based experimental prototype with 400 V input, 250–430 V output, and a switching frequency of 120–140 kHz is built to verify the theoretical analysis, and the peak efficiency reaches 97.82%.
Label‐free cell detection of acute leukemia using ghost cytometry
Authors: Kawamura Yoko , Nakanishi Kayoko , Murata Yuri , Teranishi Kazuki , Miyazaki Ryusuke , Toda Keisuke , Imai Toru , Kajiwara Yasuhiro , Nakagawa Keiji , Matsuo Hidemasa , Adachi Souichi , Ota Sadao , Hiramatsu Hidefumi 
Published: December 2023

AbstractEarly diagnosis and prompt initiation of appropriate treatment are critical for improving the prognosis of acute leukemia. Acute leukemia is diagnosed by microscopic morphological examination of bone marrow smears and flow cytometric immunophenotyping of bone marrow cells stained with fluorophore‐conjugated antibodies. However, these diagnostic processes require trained professionals and are time and resource‐intensive. Here, we present a novel diagnostic approach using ghost cytometry, a recently developed high‐content flow cytometric approach, which enables machine vision‐based, stain‐free, high‐speed analysis of cells, leveraging their detailed morphological information. We demonstrate that ghost cytometry can detect leukemic cells from the bone marrow cells of patients diagnosed with acute lymphoblastic leukemia and acute myeloid leukemia without relying on biological staining. The approach presented here holds promise as a precise, simple, swift, and cost‐effective diagnostic method for acute leukemia in clinical practice.
On the reactivity of a masked N‐heterocyclic phosphinidene towards carbonyls and isonitriles
Authors: Lüdtke Karsten Paul , Suhrbier Tim , Bresien Jonas , Villinger Alexander , Schulz Axel 
Published: December 2023

AbstractReactions of a masked N‐heterocyclic phosphinidene (mNHP, 1), a four‐membered heterocycle with a divalent P atom, with various isonitriles (tBu−NC, Dmp−NC) and carbonyls (CO, Fe(CO)5, and benzalacetone) have been studied. The isonitriles (tBu−NC and Dmp−NC) insert into a P−N bond of the four‐membered ring of 1, leading to the formation of a five‐membered heterocycle (2tBu, 2Dmp), indicating carbene‐like reactivity of the isonitriles. In exactly this way, CO, which is isolobal to isonitriles, reacts to form a five‐membered ring (3) with an exocyclic C=O double bond. If, on the other hand, Fe(CO)5 is used as a CO source, a CO molecule is inserted analogously, however, the remaining Fe(CO)4 fragment is bound via a phosphorus‐iron dative bond to the five‐membered heterocycle. When mNHP 1 reacts with the α,β‐unsaturated ketone benzalacetone, phosphinidene reactivity is observed for 1. This means that the four‐membered ring opens and the P atom reacts with the benzalacetone in a cyclization reaction to form a 1,2‐oxaphospha‐cyclopentene. Theoretical studies of the five‐membered heterocycles 2 and 3 carrying eight π electrons show that zwitterionic Lewis representations dominate in the resonance scheme and only a very low biradical character (<5 %) is found.
The impact of an additional copy of chromosome 21 in B‐cell precursor acute lymphoblastic leukemia
Authors: Hormann Femke M. , Mooij Eva J. , van de Mheen Marieke , Beverloo H. Berna , den Boer Monique L. , Boer Judith M. 
Published: December 2023

AbstractA common finding in pediatric B‐cell precursor acute lymphoblastic leukemia (BCPALL) is that chromosome 21 is never lost and an extra chromosome 21 is often gained. This implies an important role for chromosome 21 in the pathobiology of BCPALL, emphasized by the increased risk of BCPALL in children with Down syndrome. However, model systems of chromosome 21 gain are lacking. We therefore developed a BCPALL cell line (Nalm‐6, DUX4‐rearranged) with an additional chromosome 21 by means of microcell‐mediated chromosome transfer. FISH, PCR, multiplex ligation‐dependent probe amplification, and whole exome sequencing showed that an additional chromosome 21 was successfully transferred to the recipient cells. Transcription of some but not all genes on chromosome 21 was increased, indicating tight transcriptional regulation. Nalm‐6 cells with an additional chromosome 21 proliferated slightly slower compared with parental Nalm‐6 and sensitivity to induction chemotherapeutics was mildly increased. The extra copy of chromosome 21 did not confer sensitivity to targeted signaling inhibitors. In conclusion, a BCPALL cell line with an additional human chromosome 21 was developed, validated, and subjected to functional studies, which showed a minor but potentially relevant effect in vitro. This cell line offers the possibility to study further the role of chromosome 21 in ALL.
Machine learning approach to predict tracheal necrosis after total pharyngolaryngectomy
Authors: Hidaka Takeaki , Miyamoto Shimpei , Furuse Kiichi , Oshima Azusa , Matsuura Kazuto , Higashino Takuya 
Published: December 2023

AbstractBackgroundTracheal necrosis is a potentially severe complication of total pharyngolarynjectomy (TPL), sometimes combined with total esophagectomy. The risk factors for tracheal necrosis after TPL without total esophagectomy remain unknown.MethodsWe retrospectively reviewed data of 395 patients who underwent TPL without total esophagectomy. Relevant factors associated with tracheal necrosis were evaluated using random forest machine learning and traditional multivariable logistic regression models.ResultsTracheal necrosis occurred in 25 (6.3%) patients. Both the models identified almost the same factors relevant to tracheal necrosis. History of radiotherapy was the most important predicting and significant risk factor in both models. Paratracheal lymph node dissection and total thyroidectomy with TPL were also relevant. Random forest model was able to predict tracheal necrosis with an accuracy of 0.927.ConclusionsRandom forest is useful in predicting tracheal necrosis. Countermeasures should be considered when creating a tracheostoma, particularly in patients with identified risk factors.
Pharmacist dispensing of mifepristone: An opinion of the Women's Health Practice and Research Network of the American College of Clinical Pharmacy
Authors: Rafie Sally , Majerczyk Daniel , Cieri‐Hutcherson Nicole , Campbell Nicole , Stone Rebecca , Leader Lauren D. , Weddendorf Elizabeth , McBane Sarah , Karaoui Lamis R. , Herman Alexandra , Kaczmarski Katie 
Published: December 2023

AbstractA rising percentage of patients are electing medication abortion over procedural abortion for increased safety and privacy. Access to medication abortion is essential healthcare, but many Americans face unsurmountable barriers when pursuing this option. This has been in large part due to unnecessary restrictions imposed by the United States Food and Drug Administration (FDA) Risk Evaluation and Mitigation Strategy (REMS) for mifepristone, used in combination with misoprostol for medication abortion. Moreover, many states have imposed additional restrictions on abortion, further impeding access to care. Since its original approval in 2000, mifepristone can only be prescribed by certified prescribers. Until recently, mifepristone could only be dispensed by certified prescribers, whereby more accessible community and mail‐order pharmacies were prohibited from dispensing mifepristone. During the Coronavirus disease 2019 public health emergency, there was a temporary allowance for certified prescribers to utilize mail or mail‐order pharmacies to deliver medications to patients. In January 2023, the FDA approved modifications to the mifepristone REMS to allow certified pharmacies to dispense the medication. Given the established safety and effectiveness of mifepristone, the evidence supports its distribution via pharmacies and leveraging pharmacists to expand medication abortion access. Pharmacists are one of the most widely accessible healthcare providers and their responsibility centers on patient and medication safety and improving health outcomes. This article, an opinion of the American College of Clinical Pharmacy Women's Health Practice and Research Network, adds the voice of members of the pharmacy profession to the collective efforts to ensure access to medication abortion, including pharmacist dispensing of mifepristone. We encourage pharmacists to embrace this fresh opportunity to provide medication abortion care in their communities.
Ground and excited electronic structures of electride and alkalide units: The cases of Metal‐Tren, ‐Azacryptand, and ‐TriPip222 complexes
Authors: Ariyarathna Isuru R. 
Published: December 2023

AbstractA systematic electronic structure analysis was conducted for M(L)n molecular electrides and their corresponding alkalide units M(L)n@M′ (M/M′ = Na, K; L = Tren, Azacryptand, TriPip222; n = 1, 2). All complexes belong to the “superalkali” category due to their low ionization potentials. The saturated molecular electrides display M+(L)n− form with a greatly diffuse quasispherical electron cloud. They were identified as “superatoms” considering the contours of populating atomic‐type molecular orbitals. The observed superatomic Aufbau order of M(Tren)2 is 1S, 1P, 1D, 1F, 2S, 2P, and 1G and it is consistent with those of M(Azacryptand) and M(TriPip222) up to the analyzed 1F level. Their excitation energies decrease gradually moving from M(Tren)2 to M(Azacryptand) and to M(TriPip222). The studied alkalide complexes carry [M(L)n]+@M′− ionic structure and their dissociation energies vary in the sequence of K(L)n@Na > Na(L)n@Na > K(L)n@K > Na(L)n@K. Similar to molecular electrides, the anions of alkalide units occupy electrons in diffuse Rydberg‐like orbitals. In this work, excited states of [M(L)n@M′]0/+/− and their trends are also analyzed.