bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of monosodium urate monohydrate crystal–induced acute inflammation by retrovirally transfected prostaglandin D synthase
Authors: Murakami Yousuke , Akahoshi Tohru , Hayashi Izumi , Endo Hirahito , Hashimoto Atsushi , Kono Shizuka , Kondo Hirobumi , Kawai Shinichi , Inoue Matsuhisa , Kitasato Hidero 
Published: June 2004

AbstractObjectiveHematopoietic prostaglandin D synthase (H‐PGDS) is a key enzyme in the production of prostaglandin D and its J series metabolites. We evaluated the antiinflammatory effect of retrovirally transfected H‐PGDS in order to investigate the role of H‐PGDS in monosodium urate monohydrate (MSU) crystal–induced acute inflammation.MethodsExpression of endogenous PGDS in a murine air‐pouch model of MSU crystal–induced acute inflammation was determined by real‐time polymerase chain reaction. H‐PGDS complementary DNA (cDNA) was retrovirally transfected into C57BL/6J fibroblasts, and the cells were designated as C57‐PGDS cells. Production of prostaglandins by C57‐PGDS cells was measured by enzyme immunoassay. The effect of C57‐PGDS cells on crystal‐induced inflammation was investigated.ResultsInjection of the crystals caused a rapid decrease in H‐PGDS expression by infiltrating cells and by the soft tissues around the air pouches. In contrast, expression of interleukin‐1β (IL‐1β) and macrophage inflammatory protein 2 (MIP‐2) as well as cellular infiltration were significantly increased during the early stage of inflammation. C57‐PGDS cells, but not control cells, produced an increased amount of PGD2 in vitro, but suppressed production of PGE2. Injection of C57‐PGDS cells into air pouches inhibited cellular infiltration and MIP‐2 and IL‐1β expression.ConclusionIn this murine air‐pouch model of MSU crystal–induced inflammation, retrovirally transfected H‐PGDS cDNA could reduce cellular infiltration, at least partly by inhibiting MIP‐2 and IL‐1β. These findings suggest that gene therapy with H‐PGDS may be useful for treating inflammatory diseases.
Induction of arthritis in SCID mice by T cells specific for the “shared epitope” sequence in the G3 domain of human cartilage proteoglycan
Authors: Hanyecz Anita , Bárdos Tamás , Berlo Suzanne E. , Buzás Edit , Nesterovitch Andrew B. , Mikecz Katalin , Glant Tibor T. 
Published: June 2004

AbstractObjectiveTo study the immunologic function and determine the fine epitope structure of a synthetic peptide p135H (2373TTYKRRLQKRSSRHP) of the G3 domain of human cartilage proteoglycan (aggrecan), which contains a highly homologous sequence motif of the shared epitope (QKRAA), the most common sequence motif in HLA–DR4 alleles, which predispose humans to the development of rheumatoid arthritis (RA).MethodsSynthetic p135 peptides with altered sequences were used for (hyper)immunization of arthritis‐susceptible BALB/c mice and then challenged with a single dose of cartilage proteoglycan. Human p135 (p135H) and mouse p135 (p135M) synthetic peptides of the G3 domain of aggrecan were used to prime lymphocytes, which were then used for adoptive transfer of arthritis into “presensitized” SCID mice, determining cross‐reactivity among p135 peptides and their analogous sequences, and generating T cell hybridomas. T cell hybridomas were also used for arthritis transfer into SCID mice and for characterizing the fine epitope structure of T cell receptor (TCR) and major histo‐compatibility complex (MHC) binding sites of the immunogenic/arthritogenic p135H sequence.ResultsWhile p135H peptide‐(hyper)immunized mice became sensitized, they developed arthritis only after injection of a single dose of cartilage proteoglycan aggrecan. An altered peptide sequence (p135H‐AA) carrying the shared epitope motif (QKRAA) was as effective as the natural peptide p135H sequence for inducing arthritis. Mouse p135M‐specific lymphocytes induced arthritis with a lower incidence, but synthetic peptides to Escherichia coli heat‐shock protein (DnaJ) or HLA–DR4 allele (both having the shared epitope sequence with different flanking regions) were also positive. Fine epitope sequence recognition of an arthritogenic T cell hybridoma derived from p135H‐primed lymphocyte population was determined. Interestingly, in the most central position, a basic amino acid triplet of p135H peptide was found to be the MHC‐binding motif, whereas the flanking amino acids bound to the TCR.ConclusionPeptide p135H, corresponding to the peptide sequence in the G3 domain of human cartilage proteoglycan aggrecan, is immunogenic/arthritogenic in BALB/c mice. Peptide p135H includes a highly homologous motif of the shared epitope, a sequence that is overrepresented in bacterial heat‐shock proteins, envelope protein of human JC polyomavirus, and numerous HLA–DR4 alleles. Since the G3 domain of cartilage proteoglycan aggrecan with the p135 sequence is “lost” during the normal metabolic turnover of cartilage proteoglycan or in pathologic conditions, an antigenoriented T cell migration into joints of presensitized (susceptible) individuals may contribute to the organ‐specificity of RA.
Neuronal and astrocytic damage in systemic lupus erythematosus patients with central nervous system involvement
Authors: Trysberg Estelle , Nylen Karin , Rosengren Lars E. , Tarkowski Andrej 
Published: June 2004

AbstractObjectiveSymptoms originating from the central nervous system (CNS) frequently occur in patients with systemic lupus erythematosus (SLE). CNS involvement in lupus is associated with increased morbidity and mortality. Currently, reliable markers for activity in this condition are absent. The goal of this study was to determine the level of the light subunit of the neurofilament triplet protein (NFL) and that of glial fibrillary acidic protein (GFAP) in the cerebrospinal fluid of SLE patients with clinically verified CNS involvement and compare them with the levels in SLE patients without CNS involvement.MethodsWe assessed cerebrospinal fluid obtained from 99 patients with SLE and 99 age‐matched controls for the presence of soluble molecules indicating neuronal destruction and astrogliosis—NFL and GFAP, respectively. Patients were evaluated clinically, with magnetic resonance imaging (MRI) of the brain, cerebrospinal fluid analyses, and neuropsychiatric tests.ResultsIn the group of lupus patients with CNS involvement, intrathecal levels of NFL and GFAP were increased an average of 7‐fold (P ≤ 0.0001) and 3‐fold (P ≤ 0.05), respectively, compared with the levels in SLE patients without overt CNS disease. Intrathecal levels of NFL correlated significantly with cerebrospinal fluid levels of interleukin‐6 (IL‐6) (P ≤ 0.005), IL‐8 (P ≤ 0.005), pleocytosis (P ≤ 0.05), the albumin ratio (P ≤ 0.0005), and the presence of oligoclonal IgG bands (P ≤ 0.005). Cerebrospinal fluid levels of both NFL and GFAP also showed a significant correlation with MRI abnormalities (P ≤ 0.001). Successful cyclophosphamide treatment of CNS lupus resulted in significantly decreased levels of both proteins; levels of GFAP reached those observed in healthy subjects.ConclusionThis study is the first to show biochemical signs of neuronal and astrocytic damage in patients with neuropsychiatric lupus. It is suggested that biochemical markers of brain damage should be used as a followup tool in this patient group.
Stellar kinematics in the centers of globular clusters
Authors: Gerssen J. 
Published: June 2004

AbstractThe high central stellar densities in globular clusters provide a unique environment to study the fundamental dynamical process of two‐body relaxation. This process is the main driver of the dynamical evolution in the center of a globular cluster and has a profound effect on the structure of the cluster and on its stellar environment. We have obtained stellar absorption line spectra with STIS to measure the radial velocities of individual stars in the crowded center of the globular cluster M15. These data increase the number of stars with known radial velocities within the central arcsec by a factor of about three and significantly improve the constraints on the mass distribution in M15. The data provide the most detailed look of the central structure of any globular cluster and show that there is a compact dark central mass component. Similar studies using ground based facilities can be efficiently performed by employing Integral Field Units. We have started a project to better constrain the central mass density in the globular cluster M3 using the GMOS‐IFU on Gemini North. The data will also allow us to better understand the central rotation which is neither explained nor predicted by any globular cluster model. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Morphology and kinematics in thick box‐peanut bulge galaxies
Authors: Vergani D. , Dettmar R.‐J. 
Published: June 2004

AbstractBoth, observational and theoretical results support the close connection between bars and box/peanut‐shaped bulges in spiral galaxies. However, for the sub‐class of thick box/peanut‐shaped bulges, an environmental process instead of an internal mechanism is suggested to account for the prominence of the box/peanut component. In this paper a multiwavelength study of the morphology and the kinematics of a sample of thick box/peanut‐shaped bulges is presented. The results suggest a scenario in which interaction events play a significant role in the history of thick box/peanut‐shaped bulge galaxies. Most likely these sources have experienced a mass infall. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
First results from SPIFFI, II: The luminous infrared galaxy NGC 6240 and the luminous sub‐millimeter galaxy SMMJ 14011+0252
Authors: Eisenhauer F. , Tecza M. , Thatte N. , Genzel R. , Abuter R. , Iserlohe C. , Schreiber J. , Horrobin M. , Schegerer A. , Baker A.J. , Bender R. , Davies R. , Lehnert M. , Lutz D. , Nesvadba N. , Seitz S. , Tacconi L.J. 
Published: June 2004

AbstractThis is the second of two papers (I: Horrobin et al. 2003) on the first scientific results from the SPIFFI integral field spectrometer at the VLT. Here we discuss the observations and properties of the prototypical luminous infrared galaxy NGC 6240 and the luminous sub‐millimeter galaxy SMMJ 14011+0252. Taking full advantage of the excellent seeing conditions of 0.27″, our integral field spectroscopy data allow us for the first time to study in detail the stellar and gas dynamics in NGC 6240 on scales of 125 pc, and to establish a galactic shock as the origin of the strong emission from molecular hydrogen. Our observations of SMMJ 14011+0252 provide us with deep, spatially resolved near infrared spectra of the SCUBA selected luminous submillimeter galaxy at a redshift of z = 2.565, revealing a remarkably old, massive and metal‐rich starburst galaxy for the early epoch at which it is observed. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Crowded field 3D spectroscopy
Authors: Becker T. , Fabrika S. , Roth M.M. 
Published: June 2004

AbstractThe quantitative spectroscopy of stellar objects in complex environments is mainly limited by the ability of separating the object from the background. Standard slit spectroscopy, restricting the field of view to one dimension, is obviously not the proper technique in general. The emerging Integral Field (3D) technique with spatially resolved spectra of a two‐dimensional field of view provides a great potential for applying advanced subtraction methods. In this paper an image reconstruction algorithm to separate point sources and a smooth background is applied to 3D data. Several performance tests demonstrate the photometric quality of the method. The algorithm is applied to real 3D observations of a sample Planetary Nebula in M31, whose spectrum is contaminated by the bright and complex galaxy background. The ability of separating sources is also studied in a crowded field in M33. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Euro3D data format: A common FITS data format for integral field spectrographs
Authors: Kissler‐Patig M. , Copin Y. , Ferruit P. , Pécontal‐Rousset A. , Roth M.M. 
Published: June 2004

AbstractAs integral field spectrographs have become more common around the world and in Europe in particular, the need for a common data format has been recognized. Here, we present the Euro3D format that is adapted as a post‐instrumentalsignature‐removal format for all instruments within the Euro3D network. It follows the FITS standard, and includes several extensions, all of them being binary FITS tables. This article is intended to give a comprehensive overview, but does not attempt to serve as a full definition document. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Euro3D LCL I/O library
Authors: PéContal‐Rousset A. , Copin Y. , Ferruit P. 
Published: June 2004

AbstractThe Euro3D Research Training Network, dedicated to promote the use of 3D spectrography in the astronomical community, has setup a new data format, adhering to the FITS standards, to facilitate data exchange and common software developments. This article is intended to present the C library handling this format. It is not intended to be a full description of the possibilities offered by the library, but attempts to enlighten the philosophy and illustrate with some examples how powerful it can be. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
E3D, the Euro3D visualization tool II: Mosaics, VIMOS data and large IFUs of the future
Authors: Sánchez S.F. , Becker T. , Kelz A. 
Published: June 2004

AbstractIn this paper, we describe the capabilities of E3D, the Euro3D visualization tool, to handle and display data created by large Integral Field Units (IFUs) and by mosaics consisting of multiple pointings. The reliability of the software has been tested with real data, originating from the PMAS instrument in mosaic mode and from the VIMOS instrument, which features the largest IFU currently available. The capabilities and limitations of the current software are examined in view of future large IFUs, which will produce extremely large datasets. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Value of positron emission tomography in the diagnosis of recurrent oesophageal carcinoma
Authors: Kato H , Miyazaki T , Nakajima M , Fukuchi M , Manda R , Kuwano H 
Published: June 2004

Abstract

Background
Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) might be useful for staging oesophageal squamous cell carcinoma (SCC). FDG-PET may be more accurate than computed tomography (CT) in diagnosing lymph node metastasis. This retrospective study compared the ability of FDG-PET and CT to diagnose recurrent oesophageal carcinoma.

Methods
Fifty-five patients with thoracic oesophageal SCC who had undergone radical oesophagectomy were studied. The accuracy of FDG-PET and CT in detecting recurrence during follow-up was calculated using data from the first images generated by either modality that suggested the presence of recurrent disease. Lesions deemed to be equivocal on these scans were considered as positive for recurrence.

Results
Twenty-seven of the 55 patients had recurrent disease in a total of 37 organs. Locoregional recurrence was observed in 19 patients (35 per cent). Distant recurrent disease occurred in 15 patients (27 per cent) in 18 organs. Six patients had recurrence in the liver, four in the lung, six in bone and two in distant lymph nodes. FDG-PET showed 96 per cent sensitivity, 68 per cent specificity and 82 per cent accuracy in demonstrating recurrent disease. The corresponding values for CT were 89, 79 and 84 per cent. The sensitivity of FDG-PET was higher than that of CT in detecting locoregional recurrence, but its specificity was lower because of FDG uptake in the gastric tube and thoracic lymph nodes. In distant organs the sensitivity of PET in detecting lung metastasis was lower than that of CT, but its sensitivity for bone metastasis was higher.

Conclusion
FDG-PET has a larger field than CT. Combined PET–CT would appear to be an appropriate modality for the detection of recurrent oesophageal cancer.
Urinary trypsinogen activation peptide as a marker of severe acute pancreatitis
Authors: Johnson C D , Lempinen M , Imrie C W , Puolakkainen P , Kemppainen E , Carter R , McKay C 
Published: June 2004

AbstractBackgroundTrypsinogen activation peptide (TAP) may be an early marker of severe pancreatitis. Previous studies have included all patients with organ failure in the group with severe pancreatitis, although patients with transient organ failure may have a good prognosis. The aim of this study was to determine the value of urinary TAP estimation for prediction of severity of acute pancreatitis, and to validate use of several markers of prediction of severity against a new, stringent definition of severity.MethodsPatients with acute pancreatitis were recruited within 24 h of onset of symptoms. Urine and blood samples were collected for 24 h, and Acute Physiology And Chronic Health Evaluation (APACHE) II (24 h), Ranson (48 h) and Glasgow (48 h) scores were calculated. Severe acute pancreatitis was defined by the presence of a local complication or the presence of organ failure for more than 48 h.ResultsUrinary TAP levels were significantly greater in patients with severe pancreatitis than in those with mild disease during the first 36 h of admission. The highest of three estimations of TAP in the first 24 h was as effective as APACHE II at 24 h in predicting severity. At 24 h after admission, urinary TAP was better than C-reactive protein (CRP) in predicting severity. The combination of TAP and CRP at 24 h allowed identification of high- and low-risk groups. The new definition of severity excluded 24 of 190 patients with transient organ failure; none of these patients died.ConclusionUse of TAP improved early prediction of the severity of acute pancreatitis. Organ failure that resolves within 48 h does not signify a severe attack of acute pancreatitis.
Laparoscopically assisted distal gastrectomy for early gastric cancer in the elderly
Authors: Yasuda K , Sonoda K , Shiroshita H , Inomata M , Shiraishi N , Kitano S 
Published: June 2004

Abstract

Background
Open gastrectomy is associated with increased morbidity and a longer hospital stay than laparoscopically assisted gastrectomy. The aim of this study was to clarify the value of laparoscopically assisted distal gastrectomy (LDG) in the elderly, in whom co-morbid disease is generally more common.

Methods
Forty-five elderly patients (aged 70 years or more) and 57 younger patients who underwent LDG, and 28 elderly patients who underwent open distal gastrectomy (ODG) for early gastric cancer between January 1994 and April 2003 were studied. Demographics and postoperative outcomes were compared.

Results
Co-morbidity was more common in elderly patients than in younger patients who underwent LDG (25 of 45 versus 16 of 57; P = 0·004). The postoperative complication rate, time to solid diet and postoperative hospital stay were similar in these two groups. Elderly patients who underwent LDG had a significantly reduced medical complication rate (two of 45 versus six of 28; P = 0·023), time to first flatus (3·7 versus 4·2 days; P = 0·042), time to solid diet (4·6 versus 5·5 days; P = 0·011) and postoperative hospital stay (16·3 versus 23·9 days; P = 0·011) than elderly patients who had ODG.

Conclusion
LDG offers particular advantages to elderly patients with early gastric cancer, including rapid return of gastrointestinal function, fewer complications and a shorter hospital stay.
Experimental and Theoretical Investigation on the Relative Stability of the PdS2‐ and Pyrite‐Type Structures of PdSe2.
Authors: Soulard C. , Rocquefelte X. , Petit P.‐E. , Evain M. , Jobic S. , Itle J.‐P. , Munsch P. , Koo H.‐J. , Whangbo M.‐H. 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Yb8Ge3Sb5, a Metallic Mixed‐Valent Zintl Phase Containing the Polymeric 1∞[Ge4‐3] Anions.
Authors: Salvador James R. , Bilc Daniel , Mahanti S. D. , Hogan Tim , Guo Fu , Kanatzidis Mercouri G. 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Polyoxometalate Containing the {Ni2N3} Fragment: Ferromagnetic Coupling in a NiII μ‐1,1 Azido Complex with a Large Bridging Angle.
Authors: Mialane Pierre , Dolbecq Anne , Riviere Eric , Marrot Jerome , Secheresse Francis 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Crystal Structures, and Nonlinear Optical Properties of Two Cubane‐Like Cluster Compounds [(n‐Bu)4N]3 [MoS4Ag3Cl4] and [Et4N]3[WOS3Cu3I4].
Authors: Zhou Jian‐Liang , Song Ying‐Lin , Li Yi‐Zhi , Zheng He‐Gen , Xin Xin‐Quan 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Dihydroxy Bis(oxazoline) Ligands for the Palladium‐Catalyzed Asymmetric Allylic Alkylation: Experimental Investigations of the Origin of the Reversal of the Enantioselectivity.
Authors: Ait‐Haddou Hassan , Hoarau Olivier , Cramailere Dimitri , Pezet Frederic , Daran Jean‐Claude , Balavoine Gilbert G. A. 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diastereoselective Baylis—Hillman Reaction Using N‐Glyoxyloyl Camphorpyrazolidinone as an Electrophile: Synthesis of Optically Pure 2‐Hydroxy‐3‐methylene Succinic Acid Derivative.
Authors: Pan Jia‐Fu , Chen Kwunmin 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Boron Trifluoride Catalyzed Reaction of Alkyl Fluoride with Silyl Enolate, Allylsilane, and Hydrosilane.
Authors: Hirano Koji , Fujita Kazuya , Yorimitsu Hideki , Shinokubo Hiroshi , Oshima Koichiro 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
“Acetylene Zipper” Reactions and Pd—Cu‐Catalyzed Cross‐Coupling in the Synthesis of Vicinal 1,3‐Alkadiynylarylamines and Aminopyridines.
Authors: Balova I. A. , Morozkina S. N. , Sorokoumov V. N. , Vinogradova O. V. , Vasilevskii S. F. 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bicyclo[3.2.1]octane Synthons from Cyclopropenes: Functionalization of Cycloadducts by Nucleophilic Additions.
Authors: Orugunty Ravi S. , Wright Dennis L. , Battiste Merle A. , Helmich Richard J. , Abboud Khalil 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Metalation of α‐Diazocarbonyl Compounds Using Grignard Reagents. A Convenient Synthesis of α‐Diazo‐β‐ketoesters and Mixed Esters of α‐Diazomalonate.
Authors: Cuevas‐Yanez Erick , Muchowski Joseph M. , Cruz‐Alamanza Raymundo 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Oxazolidine Ring Opening and Isomerization to (E)‐Imines. Asymmetric Synthesis of Aryl‐α‐fluoroalkyl Amino Alcohols.
Authors: Gosselin Francis , Roy Amelie , O'Shea Paul D. , Chen Cheng‐yi , Volante Ralph P. 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Efficient Aza‐Baylis—Hillman Reaction of N‐Tosylated Imines with MVK, Acrolein, and Phenyl Acrylate or α‐Naphthyl Acrylate: Lewis Base Effects and A Convenient Method to Synthesize α,β‐Unsaturated β‐Amino Carbonyl Compounds.
Authors: Xu Yong‐Mei , Shi Min 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Studies on Novel Synthetic Methodologies. Part 34. Convenient and Efficient Stereoselective Synthesis of (2Z)‐2‐(Chloromethyl)alk‐2‐enoates Using Iron(III) or Indium(III) Chloride.
Authors: Das Biswanath , Banerjee Joydeep , Ravindranath Nasi , Venkataiah Bollu 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Oxime Carbapalladacycle Covalently Anchored to High Surface Area Inorganic Supports or Polymers as Heterogeneous Green Catalysts for the Suzuki Reaction in Water.
Authors: Baleizao Carlos , Corma Avelino , Garcia Hermenegildo , Leyva Antonio 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Selenobenzophenones and Diazoalkanes: Isolation of Tetraarylethylenes by the Reaction of Benzophenone Hydrazones with Diselenium Dibromide.
Authors: Okuma Kentaro , Kojima Kazuki , Oyama Kosuke , Kubo Kento , Shioji Kosei 
Published: June 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.