bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust assembly of the aldehyde dehydrogenase Ald4p in Saccharomyces cerevisiae
Authors: Nasalingkhan Channarong , Sirinonthanawech Naraporn , Noree Chalongrat 
Published: September 2023

ABSTRACT
As part of our studies of yeast aldehyde dehydrogenase (Ald4p) assembly, we identified a population of transformants (SWORD strain) that show more robust filament formation of GFP-tagged Ald4p (Ald4p-GFP) than that of a wild type ALD4::GFP strain. Sequencing of the ALD4 gene in the SWORD strain showed that the increased assembly was not due to changes to the ALD4 coding sequence, suggesting that a second mutation site was altering Ald4p assembly. Using short-read whole-genome sequencing, we identified spontaneous mutations in FLO9. Introduction of the SWORD allele of FLO9 into a wild-type ALD4::GFP yeast strain revealed that the changes to FLO9 were a contributor to the increased length of Ald4p-GFP filaments we observe in the SWORD strain and that this effect was not due to an increase in Ald4p protein levels. However, the expression of the FLO9 (SWORD) allele in wild-type yeast did not fully recapitulate the length control defect we observed in SWORD strains, arguing that there are additional genes contributing to the filament length phenotype. For our future work, this FLO9 from SWORD will be tested whether it could show global effect, promoting the assembly of some other filament-forming enzymes.
“Researches into the nature of the Involuntary Muscular Fibre.”
Authors: Ellis George Viner , Sharpey Dr. 
Published: September 2023

ABSTRACT
Having been unable to confirm the statements of Professor Kölliker respecting the cell-structure of the involuntary muscular fibre, the author was induced to undertake a series of researches into the nature of that tissue, by which he has been led to entertain views as to its structure in vertebrate animals, but more especially in man, which are at variance with those now generally received. The present communication contains the results of these inquiries, which tend to show that the voluntary and involuntary muscles resemble each other very closely in the arrangement and constitution of their fibres.
Limits to sustained energy intake. XXXIII. Thyroid hormones play important roles in milk production but do not define the heat dissipation limit in Swiss mice
Authors: Yang Rui , Cao Jing , Speakman John R. , Zhao Zhijun 
Published: September 2023

ABSTRACT
The limits to sustained energy intake set physiological upper boundaries that affect many aspects of human and animal performance. The mechanisms underlying these limits, however, remain unclear. We exposed Swiss mice to either supplementary thyroid hormones (THs) or the inhibitor methimazole during lactation at 21 or 32.5°C, and measured food intake, resting metabolic rate (RMR), milk energy output (MEO), serum THs and mammary gland gene expression of females, and litter size and mass of their offspring. Lactating females developed hyperthyroidism following exposure to supplementary THs at 21°C, but they did not significantly change body temperature, asymptotic food intake, RMR or MEO, and litter and mass were unaffected. Hypothyroidism, induced by either methimazole or 32.5°C exposure, significantly decreased asymptotic food intake, RMR and MEO, resulting in significantly decreased litter size and litter mass. Furthermore, gene expression of key genes in the mammary gland was significantly decreased by either methimazole or heat exposure, including gene expression of THs and prolactin receptors, and Stat5a and Stat5b. This suggests that endogenous THs are necessary to maintain sustained energy intake and MEO. Suppression of the thyroid axis seems to be an essential aspect of the mechanism by which mice at 32.5°C reduce their lactation performance to avoid overheating. However, THs do not define the upper limit to sustained energy intake and MEO at peak lactation at 21°C. Another, as yet unknown, factor prevents supplementary thyroxine exerting any stimulatory metabolic impacts on lactating mice at 21°C.
Exploring the adaptability of the secondary structure of mRNA to temperature in intertidal snails based on SHAPE experiments
Authors: Zhu Ya-Jie , Liao Ming-Ling , Dong Yun-Wei 
Published: September 2023

ABSTRACT
RNA-based thermal regulation is an important strategy for organisms to cope with temperature changes. Inhabiting the intertidal rocky shore, a key interface of the ocean, atmosphere and terrestrial environments, intertidal species have developed variable thermal adaptation mechanisms; however, adaptions at the RNA level remain largely uninvestigated. To examine the relationship between mRNA structural stability and species distribution, in the present study, the secondary structure of cytosolic malate dehydrogenase (cMDH) mRNA of Echinolittorina malaccana, Echinolittorina radiata and Littorina brevicula was determined using selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE), and the change in folding free energy of formation (ΔGfold) was calculated. The results showed that ΔGfold increased as the temperature increased. The difference in ΔGfold (ΔΔGfold) between two specific temperatures (25 versus 0°C, 37 versus 0°C and 57 versus 0°C) differed among the three species, and the ΔΔGfold value of E. malaccana was significantly lower than those of E. radiata and L. brevicula. The number of stems of cMDH mRNA of the snails decreased with increasing temperature, and the breakpoint temperature of E. malaccana was the highest among these. The number of loops was also reduced with increasing temperature, while the length of the loop structure increased accordingly. Consequently, these structural changes can potentially affect the translational efficiency of mRNA. These results imply that there were interspecific differences in the thermal stability of RNA secondary structures in intertidal snails, and these differences may be related to snail distribution.
Το Διδακτικό Μοντέλο Kirkpatrick στη διαδικτυακή μάθηση
Authors: Σπατιώτη (Spatioti) Αδαμαντία (Adamantia) Γεράσιμος (Gerasimos) , Καζανίδης (Kazanidis) Ιωάννης (Ioannis) , Παγγέ (Pange) Τζένη (Jenny) 
Published: September 2023

Η παρούσα εργασία έχει ως θέμα τη μελέτη του μοντέλου Kirkpatrick σε διαδικτυακά περιβάλλοντα μάθησης. Ειδικότερα, είναι σημαντικό να εξεταστεί η αποτελεσματικότητα του συγκεκριμένου μοντέλου σε ψηφιακά εξ αποστάσεως εκπαιδευτικά περιβάλλοντα. Επίσης, εκτιμάται η συμβολή του στη βελτίωση τόσο των προγραμμάτων σπουδών όσο και των εκπαιδευτικών που υιοθετούν την ηλεκτρονική μάθηση. Απώτερος στόχος είναι μέσα από την αξιολόγησή του να αναδειχθούν καλές πρακτικές εφαρμογής και βελτίωσης του συγκεκριμένου τρόπου εκπαίδευσης. Με βάση τη σχετική βιβλιογραφία, διατυπώθηκαν τα ερευνητικά ερωτήματα και υπο-ερωτήματα. Ως μεθοδολογία στην παρούσα έρευνα επιλέχθηκε η μετα-ανάλυση (meta-analysis), η οποία είναι άρρηκτα συνδεδεμένη με τη συστηματική βιβλιογραφική επισκόπηση (systematic review) και συνδυαστικά μπορεί να επιτευχθούν ασφαλή συμπεράσματα.. Ειδικότερα, αξιοποιήθηκαν συνολικά 21 άρθρα εκ των οποίων 9 κρίθηκαν κατάλληλα για το κυρίως στάδιο της μετα-ανάλυσης. Σύμφωνα με τα αποτελέσματα της έρευνας φαίνεται ότι το μοντέλο Kirkpatrick χρησιμοποιείται για τη μέτρηση της αποτελεσματικότητας προγραμμάτων κατάρτισης, κυρίως, σε σχέση με τα δύο πρώτα επίπεδα και λιγότερο και για το τρίτο επίπεδο ενώ το τέταρτο επίπεδο είναι πιο σπάνιο. Επίσης, γίνεται χρήση του, κυρίως, σε μαζικά διαδικτυακά μαθήματα (MOOCs) από Σχολές Ιατρικής. Τέλος, από τις βασικές εφαρμογές της διαδικτυακής μάθησης, η ασύγχρονη προσέγγιση προτιμήθηκε κατά την εφαρμογή του.
Case Report: A successful treatment approach of rituximab and azathioprine for pemphigus vulgaris
Authors: Potdukhe Ashwini , Sharma Ranjana , Ankar Ruchira , Wanjari Mayur 
Published: September 2023

Pemphigus Vulgaris is an uncommon autoimmune skin disorder that is characterized by persistent and blistering lesions. In approximately 50% of patients, mucous membrane erosions are the initial symptom. The primary presenting symptom is often oral mucosal erosions. Affected individuals frequently experience flaccid blisters and erosions on healthy skin and mucous membranes, and other areas of the body may also be affected. This condition is the result of autoantibodies that target desmosomal antigens. We are presenting a case of a 28-year-old male who presented to the hospital with fluid-filled lesions on his forehead and in his oral cavity. A skin biopsy was performed, and he was diagnosed with pemphigus vulgaris. Initially, he was started on a combination of steroids and azathioprine, but he did not respond to this treatment regimen. However, he was successfully treated with injection rituximab. Rituximab has been found to be an effective treatment approach towards pemphigus vulgaris. It can help prevent further complications and reduce the severity of the disease. By targeting the autoantibodies that cause the disorder, rituximab can help control the patient's symptoms and improve their quality of life. It is important to note that early diagnosis and treatment can play a critical role in the management of pemphigus vulgaris.
Marfan’s Syndrome and associated pathologies: An integrative systematic review of randomised controlled trials
Authors: Pashine Aishwarya A. , Naqvi Waqar M. , Arora Sakshi P. 
Published: September 2023

Background Marfan’s syndrome (MFS) is an autosomal dominant hereditary connective tissue disorder associated with numerous skeletal, ocular, cardiovascular, and respiratory pathologies which advance with age. Following multiple system involvement of body, the clinical presentation and management of MFS with associated pathologies are an area of cautious focus. Therefore, this review focused on highlighting various management options that are currently being supported for the MFS patients. Methodology The search methodology involved randomized controlled trials (RCTs) published between 2018 to 2022 from PubMed and Google Scholar databases. Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) were followed for reviewing the data extracted following the inclusion and exclusion criteria using the keywords “Marfan’s Syndrome”, “Irbesartan”, “Aortic Dilatation”, “Atenolol”, and “Lens Subluxation.” Results A total of eight articles were reviewed for the preferred distribution of population and the management options followed in the studies consisting of medical, psychological, and surgical interventions. Also, the associated pathologies related to MFS patients were analysed and found to have significant impact on health-related quality of life of MFS patients. Conclusions The review concluded that a combination of drugs atenolol, a β-blocker, and losartan which is an angiotensin receptor blocker, is beneficial in case of aortic root dilatation and higher aortic root stiffness. Additionally, ADRB1 testing may determine patients that are more likely to respond therapeutically to atenolol in comparison to losartan. Cionni modified capsular tension rings (MCTR) have been acknowledged as an effective device for delivering good capsular bag stabilization in cases of lens subluxation in MFS patients.
Pomnik, który nie powstał, i ofiary, których nie było?
Authors: Kumala Aleksandra 
Published: September 2023

A NON-EXISTENT MONUMENT AND NON-EXISTENT VICTIMS? ON POLISH RIVAL POSTMEMORY
The article presents a case study of a yet-to-be-realized queer monument in Warsaw, a project that originated in 2007. The monument was intended to commemorate the alleged non-existence of nonheteronormative victims of both Nazi and communist persecutions. The author examines the controversies surrounding the project and analyzes the responses from the media, politicians and Internet users, who are viewed as various types of mnemonic actors. While acknowledging valid criticisms leveled at the project, the article also explores manifestations of “Polish rival postmemory,” a notion derived from Marianne Hirsch’s concept of “postmemory” and Michael Rothberg’s “multidirectional memory.” To illustrate the mechanism whereby the process of revictimization replaces commemoration, the article also references the concepts of “mnemonic wars” and “mnemonic mobilization.”
Disclosure in Incentivized Reviews: Does It Protect Consumers?
Authors: Park Sungsik , Shin Woochoel , Xie Jinhong 
Published: September 2023

The well-documented rating inflation of incentivized reviews (IRs) can mislead consumers into choosing a product that they would otherwise not buy. To protect consumers from this undesirable influence, the U.S. Federal Trade Commission recommends that reviewers conspicuously disclose any material connection they may have with sellers. In theory, such disclosures safeguard consumers by motivating reviewers to be truthful and inducing consumers to discount inflated IR ratings. Our research finds, however, that IR disclosure accomplishes neither. Specifically, our empirical analysis of consumer reviews on Amazon reveals that, even with disclosure, (1) rating inflation of IRs remains, and (2) this inflation boosts sales at consumers’ expense. Finally, we propose an alternative approach to eliminate rating inflation of IRs and empirically demonstrate its effectiveness. These findings have important implications for consumers, firms, and ongoing policy discussions around IRs. This paper was accepted by Duncan Simester, marketing. Funding: S. Park gratefully acknowledges financial support from the Darla Moore School of Business Research Grant Program at the University of South Carolina. W. Shin gratefully acknowledges financial support from the Brian R. Gamache Endowed Professorship at the University of Florida. J. Xie gratefully acknowledges financial support from the JCPenney Endowed Professorship at the University of Florida. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.00930 .
Dynamic Placement in Refugee Resettlement
Authors: Ahani Narges , Gölz Paul , Procaccia Ariel D. , Teytelboym Alexander , Trapp Andrew C. 
Published: September 2023

Boosting Employment of Resettled Refugees Whether a resettled refugee finds employment in the United States depends in no small part on which host community they are first welcomed to. Every week, resettlement agencies are assigned a group of refugees who they are required to place in communities around the country. In “Dynamic Placement in Refugee Resettlement,” Ahani, Gölz, Procaccia, Teytelboym, and Trapp develop an allocation system that recommends where to place an incoming refugee family with the aim of boosting the overall employment success. Should capacities in high-employment areas be used up as quickly as possible, or does it make sense to hold back for a perfect match? The simple algorithm, based on two-stage stochastic programming, achieves over 98% of the hindsight-optimal employment, compared with under 90% for the greedy-like approaches that were previously used in practice. Their algorithm is now part of the Annie™ MOORE optimization software used by a leading American refugee resettlement agency.
Prevalence of work-related low back pain and associated risk factors among physiotherapists in Dhaka, Bangladesh: a cross-sectional study
Authors: Ahmed Sohel , Numan Sharker Md , Rahman Mohammad Habibur 
Published: September 2023

Background/AimsLow back pain is one of the most widespread public health concerns and physiotherapists frequently experience work-related low back pain. The aim of this study was to find out the prevalence of low back pain and the factors associated with the consequences of work-related low back pain among physiotherapists in Bangladesh.MethodsA cross-sectional study was conducted from August 2021 to January 2022 among physiotherapists working in Dhaka. A total of 212 male and female physiotherapists, aged between 22 and 40 years, participated in this study. Descriptive statistics (number and percentage) were used to express the prevalence rate and the association between pain and professional practice-related variables was measured by using the Chi-square test or Fisher's exact test where appropriate.ResultsThere were more male physiotherapists (67%) than female therapists (33%). Overall, 25% of participants reported that they had low back pain before they started working as a physiotherapist, which increased to 87.3% after they had started working as a physiotherapist. The most common therapist-related risk was incorrectly using body mechanics (50.5%), working in an awkward position (50%) and repeated bending and twisting movements (49.1%). The most common patient-related risk factor was reported as dealing with a patient who was overweight (44.8%) and the most common work-related factor was reported as lack of sufficient resting time between patients (44.8%). There was a significant association between low back pain with the designation of the therapist, working hours and the number of patients treated in a day.ConclusionsWork-related low back pain is prevalent among physiotherapists in Dhaka city. The pain was significantly associated with the designation of the therapist, working hours, and the number of patients treated by the therapist in a day. Preventive strategies, as well as proper patient handling techniques, should be followed while handling patients.
Low dark current density extended short-wavelength infrared superlattice photodetector with atomic layer deposited Al2O3 passivation
Authors: Li Hao , Lu Lidan , Yu Jing , Zheng Xiantong , Zhang Dongliang , Chen Weiqiang , Feng Yulin , Ren Guanghui , Zhu Lianqing 
Published: September 2023

We report on a low dark current density P-B-i-N extended short-wavelength infrared photodetector with atomic layer deposited (ALD) Al2O3 passivation based on a InAs/GaSb/AlSb superlattice. The dark current density of the Al2O3 passivated device was reduced by 38% compared to the unpassivated device. The cutoff wavelength of the photodetector is 1.8 µm at 300 K. The photodetector exhibited a room-temperature (300 K) peak responsivity of 0.44 A/W at 1.52 µm, corresponding to a quantum efficiency of 35.8%. The photodetector exhibited a specific detectivity (D∗) of 1.08×1011cm⋅Hz1/2/W with a low dark current density of 3.4×10−5A/cm2 under −50mv bias at 300 K. The low dark current density Al2O3 passivated device is expected to be used in the fabrication of extended short-wavelength infrared focal plane arrays for imaging.
Protocol for a cluster randomised waitlist-controlled trial of a goal-based behaviour change intervention for employees in workplaces enrolled in health and wellbeing initiatives
Authors: Alidu Lailah , Al-Khudairy Lena , Bharatan Ila , Bird Paul , Campbell Niyah , Currie Graeme , Hemming Karla , Jolly Kate , Kudrna Laura , Lilford Richard , Martin James , Quinn Laura , Schmidtke Kelly Ann , Yates James ,   On behalf of the Prevention Workplace Collaboration West Midlands
Published: September 2023

Many workplaces offer health and wellbeing initiatives to their staff as recommended by international and national health organisations. Despite their potential, the influence of these initiatives on health behaviour appears limited and evaluations of their effectiveness are rare. In this research, we propose evaluating the effectiveness of an established behaviour change intervention in a new workplace context. The intervention, ‘mental contrasting plus implementation intentions’, supports staff in achieving their health and wellbeing goals by encouraging them to compare the future with the present and to develop a plan for overcoming anticipated obstacles. We conducted a systematic review that identified only three trials of this intervention in workplaces and all of them were conducted within healthcare organisations. Our research will be the first to evaluate the effectiveness of mental contrasting outside a solely healthcare context. We propose including staff from 60 organisations, 30 in the intervention and 30 in a waitlisted control group. The findings will contribute to a better understanding of how to empower and support staff to improve their health and wellbeing.
Trial registration: ISRCTN17828539.
Light therapy for sleep disturbance comorbid depression in relation to neural circuits and interactive hormones—A systematic review
Authors: Yaodong Chen , Zhang Yingzi , Feng Guo , Lei Yuanfang , Liu Qiuping , Liu Yang 
Published: September 2023

AimTo provide an overview of the evidence on the effect of light therapy on sleep disturbance and depression, identify the light-active neural and hormonal correlates of the effect of light therapy on sleep disturbance comorbid depression (SDCD), and construct the mechanism by which light therapy alleviates SDCD.MethodsArticles published between 1981 and 2021 in English were accessed using Science Direct, Elsevier, and Google Scholar following a three-step searching process via evolved keywords. The evidence level, reliability, and credibility of the literature were evaluated using theevidence pyramidmethod, which considers the article type, impact factor, and journal citation report (JCR) partition.ResultsA total of 372 articles were collected, of which 129 articles fit the inclusion criteria and 44% were at the top of the evidence pyramid hierarchy; 50% were in the first quarter of the JCR partitions. 114 articles provided specific neural and hormonal evidence of light therapy and were further divided into three groups: 37% were related to circadian regulation circuits, 27% were related to emotional regulation circuits, and 36% were related to hormones.ConclusionsFirst, neural and hormonal light-active pathways for alleviating sleep disturbance or depression were identified, based on which the neural correlates of SDCD were located. Second, the light responses and interactions of hormones were reviewed and summarized, which also provided a way to alleviate SDCD. Finally, the light-active LHb and SCN exert extensive regulation impacts on the circadian and emotional circuits and hormones, forming a dual-core system for alleviating SDCD.
Non-invasive assessment of steatohepatitis indicates increased risk of coronary artery disease
Authors: Beer Sebastian , Babel Jonas , Martin Neef , Blank Valentin , Wiegand Johannes , Karlas Thomas 
Published: September 2023

Introduction
Fatty liver diseases (FLD), especially defined as metabolic dysfunction-associated FLD (MAFLD), is of growing importance for patients and health-care providers. Extrahepatic comorbidities, predominantly coronary artery disease (CAD), contribute to excess morbidity and mortality in FLD. Although the association of FLD and CAD is well known, underlying pathophysiological links are not fully understood. Non-invasive means of liver diagnostic enable a fast and thorough characterization of FLD. We therefore assessed the severity of FLD in a cohort of patients at risk of CAD.

Methods
Patients scheduled for coronary angiography were characterized by anthropometry, serum-based indices of liver fibrosis (NFS, FIB4), abdominal ultrasound and vibration controlled transient elastography (VCTE) including controlled attenuation parameter (CAP) and the Fibroscan-AST (FAST) score. Patients were stratified according to indication of therapeutic coronary intervention.

Results
120 patients were recruited, MAFLD was found in 41%, while advanced fibrosis or cirrhosis were present in only 5%. Coronary vascular intervention was indicated in 42% (n = 50). Severity of steatosis assessed by CAP and risk of fibrosis defined by elevated liver stiffness (VCTE>8 kPa) and fibrosis indices were associated with the need for coronary intervention. FAST score, a marker of fibrotic steatohepatitis, was elevated in the intervention group (0.22 vs. 0.12, p<0.001). Multivariate regression analysis revealed FAST score as strongest predictor of CAD (OR 2.3 95%, CI 1.40–2.96).

Discussion
MAFLD is a frequent comorbidity in patients at CAD risk, but advanced liver disease has a low prevalence in patients undergoing elective coronary angiography. Therefore, a routine VCTE-based screening for FLD cannot be recommended in cardiac patients. The association of indicators of steatohepatitis with advanced CAD points to inflammatory processes as a conjoint mechanism of both diseases.