bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fats extracted from oil press cakes, fish meat, and chicken hearts as potential CoQ10 supplements
Authors: Semeniuc Cristina Anamaria , Mandrioli Mara , Podar Andersina Simina , Ranga Floricuţa , Socaciu Maria Ioana , Ionescu Simona Raluca , Fogarasi Melinda , Fărcaş Anca Corina , Toschi Tullia Gallina , Vodnar Dan Cristian , Socaci Sonia Ancuţa 
Published: November 2023

Abstract
Coenzyme Q10 (CoQ10) is a liposoluble compound naturally occurring in plant and animal cells, with some benefits for health, mainly due to its antioxidant properties. The food industry gives large quantities of by-products and waste; these could be used to recover the natural form of CoQ10, which has a higher bioavailability than synthetic. The Folch method was used in this study to extract and characterise the fats from some food by-products (oil press cakes of rapeseed, sunflower, pumpkin, linseed, walnut, and hempseed) and waste (fish meat and chicken hearts), previously identified as sources of CoQ10, for potential uses as dietary supplements. The highest CoQ10 content was found in fats extracted from chicken hearts-CH (2041.74 µg/g) and pumpkin press cakes-PPC (661.40 µg/g). Both fats are triglycerides but have a low CVD risk (AI values below the recommended limit). CH fat is dominated by oleic acid (n-9) and PPC fat by linoleic acid (n-6). PUFAs/MUFAs ratio is above the recommended minimum in both fats; however, the n-6/n-3 PUFAs ratio in CH fat exceeds the maximum value. They also contain tocopherols (PPC-138.09 µg/g and CH-54.22 µg/g) that, along with CoQ10, give them antioxidant properties; therefore, they meet the criteria of a food supplement.
Tailoring Vibrational Excitation Pathways for High-Yield Oxidation of Methane to Methanol
Authors: Underwood Thomas , Nallapareddy Charan 
Published: November 2023

Abstract

The direct conversion of methane to methanol under mild conditions is a pathway to utilize methane and form a value-added fuel over distributed scales. However, over-oxidation of methanol limits the maximum methanol yield, energy efficiency, and scalability of the process. For the first time, we show how molecular excitations and reaction timescales can be tailored in thermal non-equilibrium to break this limit. We engineer reaction pathways to form preferential intermediates that restrict the formation of unwanted byproducts. We combine vibrational excitations with synergistic transport timescales in a one-pot reactor that control the accumulation and extraction of methanol to extend high methanol selectivity (> 30%) to high methane conversion (> 50%). We use these methods to demonstrate the highest methanol yield (> 20%) reported via single-step methane conversion at near room temperature and pressure. We generalize these advances using process descriptors to demonstrate a pathway to scalable and efficient methanol synthesis.
The relationship between type D personality and blood groups subtypes, and medication adherence in Iranian patients with type II diabetes mellitus
Authors: Dastjerdi Mahsa , Sabbagh Sima , Aliabadi Maryam Ghasemi , Shafiee Sahar , Najarzadegan Mehdi , Niknam Sara , Aliyari Roqayeh , Meamar Rokhsareh 
Published: November 2023

Abstract
Purpose
The aim of this study was to investigate the relationship between blood groups and personality types, and medication adherence in type 2 diabetes mellitus (T2DM).
Methods
302 patients with T2DM were considered in the study. Their sociodemographic information and medical history were recorded. Type D personality and medical adherence were checked using DS-14 and MMAS-8 questionnaires, respectively. Blood samples were obtained from the patients to determine the types of ABO blood groups, HbA1c, fasting blood sugar and lipid profile.
Results
No significant association was found between the patients' characteristics including demographic and laboratory information and medical adherence to treatment. However, a significant difference in medical adherence was observed between patients with type D personality; According to logistic regression model, patients with type D (OR: 6.23, (95%CI: 2.34–16.55, P < 0.001) had better adherence to medication, while the blood groups was not associated with medical adherence to treatment.
Conclusion
Type D personality cannot impair medical adherence in these patients. There was an association between type D personality and the ABO blood group, but the ABO blood group was not related to medical adherence.
Pre-post evaluation of nursing home residents’ quality of life after 16-20-weeks participation in the trishaw-passenger initiative Cycling Without Age
Authors: Ahrensberg Hannah , Eghøj Martin , Rasmussen Mette , Jørgensen Andreas , Toftager Mette , Petersen Christina Bjørk 
Published: November 2023

Abstract

Background
The "Cycling Without Age" initiative offers trishaw rides to nursing home residents, hoping to promote mobility, social interaction, and engagement, and enhancing mental health. However, empirical research investigating the effect on health and well-being is limited.
Aim
To evaluate if participation in “Cycling Without Age” is associated with increased quality of life.
Methods
The study was a 16-20-week quasi-experimental single-arm study, using a pre-post evaluation with participants acting as their own controls. A total of 52 participants (median age: 79.5 (IQR: 12.0)) from 17 Danish nursing homes were enrolled. Data was obtained through interview-based questionnaires and health examination tests for cognitive and physical functioning. The main outcome was quality of life measured by the 10-point Cantril ladder of life satisfaction. Secondly, mental health, self-efficacy, self-perceived health, loneliness, self-perceived pain, sleep quality, 6-min walk test, handgrip strength, cognitive function, and physical function and mood were examined. Changes in outcomes were analysed as mean differences by paired-sample t-tests, McNemar’s or the Marginal Homogeneity test.
Results
The mean difference from baseline to follow-up in quality of life was + 0.94 (p = 0.040). Subgroup analyses of quality of life showed that the increase was only significant among men, participants with very low physical functioning, participants with probability of cognitive impairment, and residents participating in < 6 trishaw rides. A significant increase in mood-score of 1.01 (p = 0.001) immediately after trishaw rides was also observed.
Conclusion
Findings suggest that participation in “Cycling Without Age” has an immediate significant impact on mood and is associated with a significant improved quality of life among nursing homes residents, escpecially among men and individuals with low cognitive and physical function. The study makes a valuable contribution to the field of public health by showing that trishaw activity for nursing home residents driven by volunteers can offer great potential for community-based health-promotion.
Trial registration: The study was approved by the Scientific Ethical Committee at the Capital Region of Denmark (number H-20010668) and registered in ClinicalTrials.gov (registration number: NCT04536779).
Exploring the Potential of High-Frequency Ultrasound to Enhance Liposomal Curcumin Delivery to HCC 1954 Breast Cancer Cells: A Promising Strategy for Harnessing the Therapeutic Potential of Curcumin in Cancer Treatment
Authors: Radha Remya , Paul Vinod , Anjum Shabana , Bouakaz Ayache , Pitt William , Husseini Ghaleb A. 
Published: November 2023

Abstract
Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained release of therapeutic drugs to cancer cells can reduce the whole-body cytotoxicity of the agent and deliver a safe localized treatment to the patient. There is growing interest in herbal drugs, such as curcumin, which is highly noted as a promising anti-tumor drug, considering its wide range of bioactivities and therapeutic properties against various tumors. Conversely, the clinical efficacy of curcumin is limited because of poor oral bioavailability, low water solubility, instability in gastrointestinal fluids, and unsuitable pH stability. Drug-delivery colloid vehicles like liposomes and nanoparticles combined with microbubbles and ultrasound-mediated sustained release are currently being explored as effective delivery modes in such cases. This study aimed to synthesize and study the properties of curcumin liposomes (CLs) and optimize the high-frequency ultrasound release and uptake by a human breast cancer cell line (HCC 1954) through in vitro studies of culture viability and cytotoxicity. CLs were successfully synthesized with particle sizes of 81 ± 2 nm. The synthesized liposomes were stable, encapsulated curcumin, and released curcumin upon exposure to ultrasound. In vitro studies on HCC1954 cells showed that CLs and the combination of ultrasound in the presence of Definity microbubbles, enhanced the anti-tumor activity of the herbal therapeutic agent compared to treatment without ultrasound. Furthermore, the study delved into curcumin liposomes' cytotoxic effects using an Annexin V/PI-based apoptosis assay. The treatment with CLs, particularly in conjunction with ultrasound and microbubbles, amplified cell apoptosis, particularly in the late apoptosis stage, which was attributed to heightened cellular uptake within cancer cells.
Research activities in the dielectric ceramics: information from data mining in literature
Authors: zhang wenxu , Wang Xiaochao 
Published: November 2023

Abstract
Vast published dielectric ceramics literature is a natural database for big-data analysis, discovering structure-property relationships and property prediction based on experimental conditions. We constructed a data-mining pipeline based on natural language processing (NLP) to extract property information from about 12900 dielectric ceramics articles. The micro-F1 scores for sentence classification, named entities recognition, relation extraction (related), and relation extraction (same) are 0.916, 0.827, 0.909, and 0.9, respectively. We built a dielectric ceramics database containing about 220000 aligned values of properties and normalized about 98000 data. Finally, we demonstrated the distribution of some important properties and the correlation relationships for different properties. We also analyzed the properties distribution for certain dielectric ceramics composites. The development of the dielectric ceramics was outlined. The experimental data enable us to extract the structure-property relationship in the future.
Enhancing ICU care through NGS – based identification of infectious agents : A comparative study
Authors: Ramanathan Aishwariya , Marimuthu Anusuya , Abayasekara Lalanika M. , Jeyaratnam Thurga , Chandrasekaran Vishvanath , Perera Jennifer , Ramasubramanium Venkatasubramanium , Sethuraman Nandini , Samarasinghe Sumudu , Peiris Varuna , Gnanam Vaz S 
Published: November 2023

Abstract
Background:
Use of molecular techniques to accurately identify the infectious disease is well established. Molecular techniques like PCR or RT PCR rely on specific gene targets in a designated pathogen for detection. In contrast, PCR with universal targets along with Next generation sequencing can cover a broad range of organisms including anerobic, fastidious and slow growing organisms and is not limited to a single organism or panel of pathogens. The Bactfast product from Credence Genomics has been previously evaluated for the diagnosis of infections in the clinical samples and showed sensitivity of 91.8% when compared with conventional cultures. The aim of this study is to evaluate the use of Bactfast and Fungifast for the diagnosis of infectious disease in a clinical ICU setting while using conventional culture as a gold standard.
Methods:
Clinical samples from sterile sites including blood were collected and processed using Bactfast and Fungifast product. Results were compared with conventional culture techniques including MALDI-TOF (VITEK-MS, Biomerieux), VITEK-2 compact.
Results:
A total of 490 samples were processed, 111 samples processed with Bactfast showed concordance with culture positive results. 322 samples and 472 samples processed with Bactfast and Fungifast respectively showed a concordance with culture negative results. Bactfast showed sensitivity of 94.1% and specificity of 86.6% compared with culture results. Only 12 fungal culture positives were observed in the total of 490, which is not sufficient to calculate the sensitivity of Fungifast and further studies required.
Conclusion:
Since the fungal culture positive samples are low, the sensitivity of the Fungifast could not be concluded in this study. However, it is clear that these products can be used for the diagnosis of infectious agents within 36 hours in the sterile samples and blood where there are limitations to culture. Furthermore, as these products are designed as pan bacterial and fungal assays, it is a versatile tool that is able to identify rare pathogens as well as conventional microbes. Therefore, Bactfast and Fungifast are useful diagnostic tools for use in the clinical ICU setting.
Liquefaction of latex glove waste for volume reduction
Authors: Kim Sung-Wook , Oh Maeng-Kyo , Jeon Min Ku 
Published: November 2023

Abstract
The accumulation of dry active wastes (DAWs) such as latex gloves in nuclear facilities has become a serious issue because of the high cost and limited storage area for their management. In this study, the liquefaction of latex gloves, which mainly comprise rubber and CaCO3, was investigated as a waste reduction technique. When liquefaction occurred at > 270°C, the latex gloves decomposed into gaseous, liquid, and solid products. Cs-, Sr-, and Co-contaminated latex gloves were liquefied at 350°C, and the solid product was subsequently recovered via distillation. Notably, the contaminants comprising CaCO3 and char only remained in the solid product (~ 33.3 wt.%); thus, the gaseous and liquid products could be regarded as non-radioactive, thereby reducing the volume of radioactive waste (~ 92.7% reduction after compression). Liquefaction is favorable compared to conventional combustion because it generates less harmful gases by converting the organic components to condensed phases.
Effect of Ropivacaine combined with Nalbuphine in Erector Spinae Plane Block on postoperative analgesia in Lumbar trauma surgery
Authors: Zhang Jin , Zhang Fan , Chen Jun , Sun Jinnan , Wang Shaolin 
Published: November 2023

Abstract
Backgroud
Erector spinae plane block (ESPB) has been gradually applied to postoperative analgesia in Thoracic, Abdominal, and Spinal Surgery. However, the action time of local anesthetics is limited. Nalbuphine was used as an adjuvant of Ropivacaine to observe the postoperative analgesic effects of ESPB after lumbar trauma surgery.
Methods
This is a single-center, prospective, randomized, double-blinded, controlled research. Patients aged between 18 and 65 years, with ASA physical status I to Ⅱ, and scheduled for an elective surgical procedure. Ultrasound-guided ESPB was performed with 0.375% ropivacaine in group R and 0.375% ropivacaine combined with 10 mg nalbuphine in group N (each side dose 20 mL). The primary outcome measure was the first postoperative remedy analgesia time. The secondary outcome measures of the study were NRS scores for rest and during movement at 4 hr, 6 hr, 8 hr, 10 hr, 12 hr, 24 hr and 48 hr after extubation, accumulated consumption dose of sufentanil at 0–4 hr, 4–8 hr, 8–12 hr, 12–24 hr and 0–24 hr after surgery, intraoperative dosage of remifentanil and sufentanil, first off-bed time, first exhaust time and length of hospital stay.
Results
A total of 57 participants completed the study. The mean difference of the first postoperative remedy analgesia time(group N vs group R, 489 ± 52 min vs 391 ± 23 min) was 98 min (95%CI, 76 to 119). Kaplan Meier survival analysis showed increasing pain-free population in group N and pain-free time Log-rank (Mantel Cox) test showed the hazard ratio (HR, group N/group R) was 0.225 (95% CI, 0.114 to 0.443). NRS scores at rest at 8 hr, 10 hr and 12 hr after surgery in group N were significantly lower than those in group R(P < 0.05). NRS scores during movement at 8 hr and 10 hr after surgery in group N were significantly lower than those in group R(P < 0.05). Compared with group R, the cumulative consumption dose of sufentanil in group N at 4–8 hr, 8–12 hr and 0–24 hr after surgery was significantly reduced (P < 0.001). There was no statistically significant difference in postoperative complications, first off-bed time, first exhaust time, length of hospital stay and satisfaction situation between the two groups.
Conclusion
Compared with ropivacaine alone, the application of ropivacaine combined with nalbuphine for ESPB in posterior lumbar surgery can prolong the postoperative pain relief time significantly and reduce the patient's demand for analgesics.
Inequalities in the Utilisation of Reproductive, Maternal, Newborn, and Child Health Interventions within Scheduled Tribes in India: An Analysis of Odisha and Jharkhand
Authors: S Rekha , Mohan Varshini Neethi , Vaidyanathan Girija , Dash Umakant , R Muraleedharan V 
Published: November 2023

Abstract
Background: The utilisation of Reproductive, Maternal, Newborn and Child Health (RMNCH) services remains lower among the Scheduled Tribes (ST) in India than among the rest of the country’s population. The tribal population's poorest and least-educated households are further denied access to RMNCH care due to the intersection of their social status, wealth, and education levels. The study analyses the wealth- and education-related inequalities in the utilisation of RMNCH services within the ST population in Odisha and Jharkhand.
Methodology: We have constructed two summary measures, namely Co-coverage indicator and a modified Composite Coverage Index (CC), to determine wealth- and education-related inequalities in the utilisation of RMNCH indicators within the ST population in Odisha and Jharkhand. The absolute and relative inequalities with respect to wealth and education within the ST population are estimated by employing the Slope Index of Inequality (SII) and the Relative Index of Inequality (RII).
Results: The results of the study highlight that access to RMNCH services is easier for women who are better educated and belong to wealthier households. The SII and RII values in the co-coverage indicator and modified CCI exhibit an increase in wealth-related inequalities in Odisha between NFHS-4 (2015-16) and NFHS-5 (2019-21). Whereas, in Jharkhand, the wealth- and education-related absolute and relative inequalities present a reduction between 2016 and 2021. Among the indicators, utilisation of vaccination was high, while the uptake of Antenatal Care Centre Visits and Vitamin A supplementation should be improved.
Interpretation: The study results underscore the urgency of targeted policies and interventions to address the inequalities in accessing RMNCH services among ST communities. A multi-dimensional approach that considers the socioeconomic, cultural and geographical factors affecting healthcare should be adopted while formulating health policies to reduce the inequalities in access to healthcare.
Automated Broad-Spectrum Bacterial Capture from Blood Using Vancomycin and Allantoin-Conjugated Polydopamine-Coated Magnetic Nanoparticles for Sepsis Diagnostics
Authors: Teyib Abafogi Abdurhaman , Lee Jinyeop , Kim Joochan , Lee Sei Won , Jang Seongsoo , Park Sungsu 
Published: November 2023

Abstract
In the realm of sepsis diagnostics, timely and precise identification of causative bacteria is crucial for effective patient care. This study introduces a groundbreaking method that harnesses vancomycin (Van)- and allantoin (Al)-conjugated polydopamine (PDA)-coated magnetic nanoparticles (MNPs) to achieve rapid and automated preconcentration and DNA extraction of sepsis-inducing bacteria from blood. The PDA coating ensures optimal dispersion of MNPs, allowing larger sample volumes to assay sensitivity and specificity. Notably, the immunomagnetic separation (IMS) method, enabled by Al/Van-PDA-MNPs, avoids the need for preliminary sample pretreatments, offering a swift, yet efficient avenue for bacterial preconcentration and DNA extraction. The sample preparation process concludes in less than 1 hour. Short processing times paired with accuracy of the method suggest this as a feasible diagnostic tool for various healthcare settings, from small clinics to expansive hospitals. Moreover, the system's strategic use of nanoparticles for DNA extraction illuminates the potential for breakthroughs in sepsis diagnostics, fostering earlier interventions and better patient outcomes.
Validation of sleep-staging accuracy for an in-home sleep electroencephalography device: A comparison with simultaneous polysomnography in patients with obstructive sleep apnea
Authors: Seol Jaehoon , Chiba Shigeru , Kawana Fusae , Tsumoto Saki , Masaki Minori , Tominaga Morie , Amemiya Takashi , Tani Akihiro , Hiei Tetsuro , Yoshimine Hiroyuki , Kondo Hideaki , Yanagisawa Masashi 
Published: November 2023

Abstract
Efforts to simplify standard polysomnography (PSG) in laboratories, especially for obstructive sleep apnea (OSA), and to assess its agreement with portable electroencephalogram (EEG) devices are limited. We aimed to evaluate the agreement between a portable EEG device and type I PSG in patients with OSA and examined the EEG-based arousal index's ability to estimate apnea severity. We enrolled 77 Japanese patients with OSA who underwent simultaneous type I PSG and portable EEG monitoring. Combining pulse rate, oxygen saturation (SpO2), and EEG data improved sleep staging accuracy. Bland-Altman plots, paired t-tests, and receiver operating characteristics curves were used to assess agreement and screening accuracy. Significant small biases were observed for total sleep time, sleep latency, awakening after falling asleep, sleep efficiency, N1, N2, and N3 rates, and arousal index. All variables showed > 95% agreement in the Bland-Altman analysis, with interclass correlation coefficients ranging from 0.76–0.982, indicating high inter-instrument validity. The EEG-based arousal index demonstrated sufficient power for screening AHI ≥ 15 and AHI ≥ 30. Portable EEG device showed strong agreement with type I PSG in patients with OSA. Additionally, the EEG-based arousal index yielded promising results in predicting apnea severity. This suggests that patients with OSA may assess their condition at home.