bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN STRATEGI KOMUNIKASI PEMASARAN PELAKU USAHA MIKRO MAKANAN RINGAN DALAM MENARIK MINAT BELI KONSUMEN (Studi Kasus pada Gipang Lestari di Kecamatan Citangkil Kota Cilegon)
Authors: Diah Delima Isniyunisyafna , Salsabil Luna Safitri , Widyatari Delima 
Published: November 2023

Dalam dunia bisnis, manajemen strategi pemasaran memiliki peran yang amat sangat penting dalam tahap pembentukan kesadaran dan pemahaman konsumen terhadap produk yang ditawarkan. Dengan demikian, sebuah perusahaan membutuhkan perencanaan strategi yang tepat agar dapat diterima dengan mudah oleh masyarakat. Penelitian ini dengan judul Penerapan strategi komunikasi pemasaran pelaku usaha mikro makanan ringan Gipang Lestari” dalam menarik minat beli konsumen. Tujuan penelitian ini adalah untuk menganalisis strategi komunikasi pemasaran pelaku usaha mikro makanan ringan “Gipang Lestari” di Kecamatan Citangkil Kota Cilegon dalam menarik minat beli konsumen dan menentukan dan menganalisis strategi pemasaran yang dilakukan oleh pelaku usaha mikro makanan ringan “Gipang Lestari” di Kecamatan Citangkil Kota Cilegon dalam menarik minat beli konsumen dengan menggunakan metode analisis SWOT. Penelitian ini menggunakan metode kualitatif pendekatan studi kasus. Adapun sumber data yang digunakan adalah data-data primer dan sekunder dari wawancara mendalam, studi kepustakaan dan dokumentasi. Data akan dianalisa dengan metode deskriptif analisis. Landasan teori yang digunakan adalah teori bauran pemasaran dan analisis SWOT. Berdasarkan analisa data yang dilakukan, diperoleh kesimpulan bahwa penerapan strategi komunikasi pemasaran yang dilakukan oleh pelaku usaha makanan ringan Gipang Lestari ini adalah dengan menggunakan direct marketing, personal selling atau penjualan langsung tatap muka dengan cara berjualan langsung dirumah dan media sosial marketing dengan menggunakan pemasaran online berupa SW atau Story WhatsApp untuk mempromosikan produknya kepada konsumen. Whatsapp sebagai salah satu media sosial saat ini banyak yang menggunakan untuk kepentingan bersosialisasi maupun sebagai penyampaian pesan baik oleh individu maupun kelompok. Berdasarkan analisis SWOT strategi dalam pengembangan strategi komunikasi pemasaran yang bisa dilakukan oleh Pelaku Usaha Makanan Ringan Gipang Lestari diantaranya: meningkatkan strategi pemasaran melalui sosial media dengan mengikuti kemajuan teknologi, melakukan kegiatan sebagai event agar dapat meningkatkan kepopularitas merek Gipang Lestari dimata masyarakat, mempertahankan harga produk makanan ringan yang terjangkau agar tidak kalah saing dengan pelaku usaha mikro yang mengeluarkan produk yang sama dan harus memanfaatkan teknologi komunikasi dengan baik.
In vitro drug interaction of ionophores with artemisinin and chloroquine against Plasmodium falciparum 3D7 blood-stage infection
Authors: Rajendran Vinoth , Gurukkalot Keerthana 
Published: November 2023

The prevalence of clinical resistance of P. falciparum towards artemisinin and its partner drugs has significantly hampered malarial chemotherapy. To circumvent this situation, identifying a new class of partner drugs with significant anti-malarial efficacy and multi-stage activity can slow the development of resistance. This study demonstrates the potential interactions of carboxylic ionophores such as monensin (MON), maduramicin (MAD) or salinomycin (SAL) with standard antimalarial drugs artemisinin (ART) or chloroquine (CQ). The in vitro drug interactions were studied in P. falciparum 3D7 strain by a growth inhibition SYBR green 1 assay. The asynchronized parasites were exposed for 48 h in the presence of varying proportions of two drug concentrations using the modified fixed-ratio isobologram method. We determined the growth inhibition response and the sums of the fractional inhibitory concentrations (ΣFICs) of the following drug combinations (4:1, 3:2, 2:3, 1:4) and (1:1, 1:3, 3:1) were calculated for 50% inhibitory concentrations (IC50s). Combining artemisinin with monensin, maduramicin, or salinomycin showed significant additive interaction. A combination of chloroquine with monensin, maduramicin, or salinomycin showed slight synergism to additive interaction. None of the drug combinations displayed an antagonistic effect indicating ionophores usage in combination therapy to treat drug-resistant malarial infections.
Cumulative live birth rate in mild versus conventional stimulation in progestin-primed ovarian stimulation protocols for individuals with low prognosis
Authors: Zhang Junwei , Du Mingze , Zhang Caihua , Wu Yanli , Guan Yichun 
Published: November 2023

ObjectiveThe purpose of this study was to evaluate the cumulative live birth rate (CLBR) of mild stimulation and conventional stimulation for the low-prognosis population undergoing PPOS protocols.MethodsThis was a retrospective cohort study. We included women with a low prognosis. All women underwent PPOS protocols, and the starting gonadotropin (Gn) dose was 150 IU or 300 IU. The primary outcome measure was CLBR. The secondary outcome measures were the number of oocytes retrieved, number of 2PN oocytes and number of available embryos.ResultsIn total, 171 women with mild stimulation and 1810 women with conventional stimulation met the criteria. In the PSM model, 171 mild stimulation cycles were matched with 513 conventional stimulation cycles. The gonadotropin dosage in the mild stimulation group was significantly lower than that in the conventional stimulation group (1878.6 ± 1065.7 vs. 2854.7 ± 821.0, P&lt;0.001). The numbers of oocytes retrieved, 2PN oocytes, available embryos and high-quality embryos were also higher in the conventional stimulation group than in the mild stimulation group (P&lt;0.05). There was no significant between-group difference in the cumulative clinical pregnancy rate (26.3% vs. 27.5%, P=0.77). The CLBR after mild stimulation was similar to that after conventional stimulation (21.1% vs. 22.0%, P=0.79).ConclusionIn our study, we found that the CLBRs of mild stimulation and conventional stimulation were similar, despite conventional stimulation resulting in significantly more oocytes and embryos. Thus, mild stimulation can be considered an option for women with a low prognosis in PPOS protocols.
Recent advances in the applications of machine learning methods for heat exchanger modeling—a review
Authors: Zou Junjia , Hirokawa Tomoki , An Jiabao , Huang Long , Camm Joseph 
Published: November 2023

Heat exchanger modeling has been widely employed in recent years for performance calculation, design optimizations, real-time simulations for control analysis, as well as transient performance predictions. Among these applications, the model’s computational speed and robustness are of great interest, particularly for the purpose of optimization studies. Machine learning models built upon experimental or numerical data can contribute to improving the state-of-the-art simulation approaches, provided careful consideration is given to algorithm selection and implementation, to the quality of the database, and to the input parameters and variables. This comprehensive review covers machine learning methods applied to heat exchanger applications in the last 8 years. The reviews are generally categorized based on the types of heat exchangers and also consider common factors of concern, such as fouling, thermodynamic properties, and flow regimes. In addition, the limitations of machine learning methods for heat exchanger modeling and potential solutions are discussed, along with an analysis of emerging trends. As a regression classification tool, machine learning is an attractive data-driven method to estimate heat exchanger parameters, showing a promising prediction capability. Based on this review article, researchers can choose appropriate models for analyzing and improving heat exchanger modeling.
Diversity of classic and novel human astrovirus in outpatient children with acute gastroenteritis in Shanghai, China
Authors: Lu Lijuan , Zhong Huaqing , Xu Menghua , Jia Ran , Liu Pengcheng , Su Liyun , Cao Lingfeng , Zhu Xunhua , Xu Jin 
Published: November 2023

IntroductionHuman astrovirus (HAstV) is an important pathogen of acute gastroenteritis (AGE) in children. This study was aimed at investigating the diversity and epidemiology of classic and novel HAstV in outpatient children aged 0–16 years old with AGE in Shanghai.MethodsFrom May 2020 to December 2022, a total of 1,482 stool samples were collected from children diagnosed as AGE from the Children’s Hospital of Fudan University. HAstV was identified using pan-astrovirus consensus primers by Reverse transcription PCR.ResultsDuring the study period, 3.3% (49/1,482) of specimens were identified as HAstV, with a detection rate of 2.5% (37/1,482) for classic HAstV and 0.8% (12/1,482) for novel HAstV. Among the 12 novel HAstV strains, 11 (91.7%) belonged to the HAstV-MLB and 1 (8.3%) was HAstV-VA. Genotyping revealed six circulating genotypes. Strain HAstV-1 was predominant in the study population with a detection rate of 1.8% (26/1,482) followed by HAstV-MLB1 (0.7%, 10/1,482) and HAstV-4 (0.6%, 9/1,482). Of note, all the HAstV-4 strains detected in this study were close to one astrovirus strain isolated from Bactrian camels with 99.0-100.0% amino acid sequences identity. In this study, HAstV was detected in all age groups with the highest detection rate of HAstV-positive specimens observed in children older than 73 months (5.7%, 12/209).DiscussionThis study provided useful information and contributed to the molecular epidemiology of both classic and novel HAstV, which were simultaneously characterized and reported for the first time in Shanghai.
Elucidating the causal association between gut microbiota and intrahepatic cholangiocarcinoma through Mendelian randomization analysis
Authors: Chen Zhitao , Shi Weiguang , Chen Kailei , Lu Chicheng , Li Xinyuan , Li Qiyong 
Published: November 2023

BackgroundIntrahepatic cholangiocarcinoma (ICC) is an aggressive liver cancer with poor prognosis. The gut microbiota has been linked to ICC, but evidence for causality is lacking. Elucidating causal gut microbiota-ICC links could inform prevention and treatment strategies.Materials and methodsWe performed a bidirectional two-sample Mendelian randomization (MR) study to investigate causal associations between gut microbiota and ICC risk. Genome-wide significant single nucleotide polymorphisms (SNPs) associated with gut microbiota abundances were utilized as instrumental variables (IVs). Multiple methods assessed causality and sensitivity analyses evaluated result robustness. Bioinformatics analysis of genetic loci linked to gut microbiota and ICC examined potential mechanisms.ResultsGenetically predicted increases in Veillonellaceae, Alistipes, Enterobacteriales, and Firmicutes were suggestively associated with higher ICC risk, while increases in Anaerostipes, Paraprevotella, Parasutterella, and Verrucomicrobia appeared protective. Bioinformatics analysis revealed differentially expressed genes near gut microbiota-associated loci may influence ICC through regulating pathways and tumor immune microenvironment.ConclusionOur findings provide suggestive evidence for causal links between specific gut microbiota and ICC risk.
A nomogram to predict the treatment benefit of perampanel in drug-resistant epilepsy patients
Authors: Zhu Chaofeng , Li Juan , Wei Dazhu , Wu Luyan , Zhang Yuying , Huang Huapin , Lin Wanhui 
Published: November 2023

ObjectiveThe objective of this study was to identify the factors that affect the efficacy of added perampanel for the treatment of drug-resistant epilepsy (DRE), and to develop a reliable nomogram to predict the benefit of this addition.MethodsA retrospective clinical analysis was conducted on DRE patients who received perampanel treatment and who were followed up for at least 6 months from January 2020 and September 2023 at the Epilepsy Center of Fujian Medical University Union Hospital. Data from January 2020 to December 2021 were used as development dataset to build model, while the data from January 2022 to September 2023 were used as validation dataset for internal validation. The predictive factors that affected the efficacy of perampanel as DRE treatment were included in the final multivariate logistic regression model, and a derived nomogram was established.ResultsA total of 119 DRE patients who received perampanel treatment were included in this study (development datasets: n = 76; validation data: n = 43). Among them, 72.3% (n = 86) showed a 50% or greater reduction in seizure frequency after perampanel treatment. Of all the parameters of interest, sex, age, history of generalized tonic-clonic seizures, and the number of antiseizure medications were identified as significant predictors for estimating the benefit of adding perampanel for the treatment of DRE. A model incorporating these four variables was developed, and a nomogram was constructed to calculate the probability of benefit of adding perampanel using the model coefficients. The C-index of the predictive model was 0.838, and the validation C-index was 0.756. The goodness-of-fit test showed good calibration of the model (p = 0.920, 0.752 respectively).ConclusionThe proposed nomogram has significant clinical potential for predicting the probability of benefit of perampanel as DRE treatment. This nomogram can be used to identify DRE patients who could benefit from the early addition of perampanel to their treatment regimen.
Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
Authors: Weiler Marina , Stieger Kevin C. , Shroff Kavisha , Klein Jessie P. , Wood William H. , Zhang Yongqing , Chandrasekaran Prabha , Lehrmann Elin , Camandola Simonetta , Long Jeffrey M. , Mattson Mark P. , Becker Kevin G. , Rapp Peter R. 
Published: November 2023

IntroductionTranscranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several neurological conditions, but its complex molecular basis is largely unexplored.MethodsUtilizing three experimental rat models (in vitro, ex vivo, and in vivo) and employing genome-wide microarray analysis, our study reveals the extensive impact of rTMS treatment on gene expression patterns.ResultsThese effects are observed across various stimulation protocols, in diverse tissues, and are influenced by time and age. Notably, rTMS-induced alterations in gene expression span a wide range of biological pathways, such as glutamatergic, GABAergic, and anti-inflammatory pathways, ion channels, myelination, mitochondrial energetics, multiple neuron-and synapse-specific genes.DiscussionThis comprehensive transcriptional analysis induced by rTMS stimulation serves as a foundational characterization for subsequent experimental investigations and the exploration of potential clinical applications.
Epidemiology of classic psychedelic substances: results from a Norwegian internet convenience sample
Authors: Kvam Tor-Morten , Uthaug Malin V. , Andersen Kristoffer A. A. , Refsum Birk Berggrav , Tunstad Paula Aarseth , Stewart Lowan Han , Jacobsen Henrik Børsting , Grønnerød Cato 
Published: November 2023

ObjectiveIn recent years, there has been a renewed interest in investigating the use of classic psychedelics such as psilocybin and lysergic acid diethylamide (LSD) in the treatment of mental disorders and substance use disorders. However, knowledge about the epidemiology of classic psychedelics in the Nordic countries is limited.MethodsWe recruited adult, Norwegian participants who have had a memorable experience after taking a classic psychedelic substance. They filled in an anonymous internet survey with 119 items covering matters related to recreational use of psychedelics using a secure, web-based application. Data are presented by using descriptive statistics (frequencies, means, and standard deviations).ResultsWe recruited 841 participants, 770 (72% male; 88% 45 years or younger) of which were included in the data analysis. The intentions behind taking the psychedelic substance were mainly recreational (46.1%) or therapeutic (42.3%). Most participants reported that their most memorable experience was with psilocybin. As in modern era clinical trials, most participants were well-prepared before, did processing during, and did integration work after the experience, whereas only a minority were supported by a therapist. Self-perceived symptoms of various mental disorders and substance use disorders were prevalent in the sample. Most subjects reported improvements in their condition. Although adverse reactions were usually mild and short-lived, 4.2% lasted for 1 year or more. Persisting flashbacks were present for a year or more among 2.9% of the participants.ConclusionIn this cross-sectional sample of Norwegian, self-selecting adults, we shed light on what characterizes the most memorable experience with a classic psychedelic substance, including short- and long-term risks and benefits. For the most part, the psychedelic experience led to improvements in self-perceived symptoms of mental disorders and substance use disorders. However, a small subset experienced persisting adverse reactions.
Association between dietary protein intake, diet quality and diversity, and obesity among women of reproductive age in Kersa, Ethiopia
Authors: Roba Aklilu Abrham , Assefa Nega , Roba Kedir Teji , Dessie Yadeta , Hamler Elena , Fawzi Wafaie 
Published: November 2023

IntroductionIn Ethiopia, there is limited evidence on the effect of dietary protein intake on women’s body mass index. Therefore, this study investigated the association between dietary protein intake, diet quality, and overweight and obesity.MethodsA cross-sectional study was conducted among 897 women of reproductive age. Food frequency questionnaires were used to assess 7-day dietary intake. It was converted into protein and other macro-nutrient intakes, Minimum Dietary Diversity for Women, and Global Dietary Quality Score. Body Mass Index (BMI) of overweight &amp; obese women were defined as ≥25 kg/m2. An adjusted odds ratio with a 95% confidence interval (in a multivariate logistic regression model) was used to determine the strength of the association between BMI and dietary protein intake, adjusting for potential confounders.ResultsThe median dietary protein intake was 41.3 (32.9, 52.6) grams/day or 0.8 (0.6, 1.0) grams/kilogram of body weight/day. The prevalence of overweight and obesity was 7.5% (n = 67). Only 220 (24.5%) women could meet the recommended minimum dietary diversity of five or more food groups out of 10 per day. Furthermore, only 255 (28.4%) women were found to have a low risk for nutrient adequacy. Interestingly, women who consumed moderate dietary protein had a significantly lower likelihood of being overweight or obese, with AOR of 0.21 (95% CI 0.10–0.48). Similarly, those who consumed a high amount of protein had even lower odds, with AOR of 0.03 (95% CI 0.01–0.14), compared to those who consumed a low amount of dietary protein. Age of 40–49 years (AOR = 3.33, 95% CI 1.24–8.95) compared to 18–29 years, non-farmers (AOR = 3.21, 95% CI 1.55–6.62), higher consumption of food from unhealthy groups (AOR = 1.30, 95% CI 1.05–1.61), and high fat intake (AOR = 1.06, 95% CI 1.04–1.09) were associated with overweight and obesity.Conclusions and recommendationsThe study indicated an inverse relationship between BMI and dietary protein intake. It also revealed that women who consumed foods from unhealthy or unhealthy when consumed in excessive amounts were more likely to be overweight or obese. Increasing dietary protein consumption can help reproductive-age women reduce the odds of obesity and overweight. Furthermore, community-based educational programs, policy changes, and healthcare services can support this effort.
Effectiveness of a positive deviance approach to improve mother’s nutritional knowledge, attitude, self-efficacy, and child’s nutritional status in Maji District, West Omo Zone, South West region, Ethiopia: a cluster randomized control trial
Authors: Gizaw Abraham Tamirat , Sopory Pradeep , Sudhakar Morankar 
Published: November 2023

BackgroundAchieving appropriate feeding for infants and young children continues to be a struggle. These impediments are not only due to limited food availability but also inadequate knowledge, unfavorable attitudes, and low self-efficacy. A positive deviant approach (PDA) addressing positive and possible solutions inherent in a community focusing on problems is applied in Africa and particularly to Ethiopia. Therefore, this trial is aimed at evaluating the effectiveness of PDA in improving mothers’ nutritional knowledge, attitudes, self-efficacy, and children’s nutritional status.MethodThis was a cluster randomized control trial in which 516 mothers were randomly assigned to either an intervention or control group after collecting baseline data. The trial participants in the intervention cluster received a positive deviant intervention for 6 months, whereas those in the control group received only the usual care. Trained positive deviant mothers (PDM) delivered the intervention. A pretested, structured, interviewer-administered questionnaire was used for data collection. Generalized estimating equation regression analysis adjusted for baseline covariates and clustering was used to test the intervention effect.ResultThe results showed that PDA improved breastfeeding outcomes in the intervention groups compared to their counterparts. A mean difference (MD) of breastfeeding (BF) knowledge (MD = 6.47; 95% CI: 6.45–6.49), BF attitude (MD = 12.68; 95% CI: 11.96–13.40), and BF self-efficacy (MD = 3.13; 95% CI: 3.05–3.21) was observed favoring the intervention. The intervention group showed better improvement in complementary feeding (CF) knowledge, attitude, and self-efficacy among mothers compared to the control group. A mean difference in CF knowledge (MD = 4.53, 95% CI: 4.31–4.75), CF attitude (MD = 9.14, 95% CI: 8.52–9.75), and CF self-efficacy (MD = 11.64, 95% CI: 11.16–12.12) were observed favoring the intervention. At the end of the 6-month follow-up, children in the intervention group showed a lower prevalence of underweight (18.23%) (95% CI: 4.55, 22.54%; p = 0.004) compared with the control group.ConclusionPDA was effective in improving mothers’ nutritional knowledge, attitude, and self-efficacy and reducing children’s underweight in the intervention area.Clinical trial registration:ClinicalTrials.gov, identifier PACTR202108880303760.
Optimal Conservative Therapy Use among Adult Cure Glomerulonephropathy Participants with IgA Nephropathy
Authors: Rajasekaran Arun , Larkina Maria , Julian Bruce A. , Canetta Pietro A. , Roehm Bethany A. , Khalid Myda , Mariani Laura H. , Rizk Dana V. 
Published: November 2023

Key Points

Optimal supportive therapy with BP and proteinuria control is pivotal in treating patients with IgA nephropathy.Suboptimal treatment of hypertension and proteinuria persisted in many patients with IgA nephropathy in the Cure Glomerulonephropathy Network study.Many patients had above-target proteinuria despite optimal BP control and may benefit from novel therapies or clinical trials.