bluuebunny/crossref_metadata_2025_split huggingface dataset:
SAKARATUL MAUT DALAM PERSPEKTIF Al-QUR’AN MENURUT NASKAH SYEIKH ZAINAL ABIDIN BIN MUHAMMAD ALFATONI
Authors: Rapiqi Apzalul , Hanisah Pipit , Zilpa Indah , Kalsum Umi 
Published: October 2023

Abstract: Every living thing must die. Death must be understood as something that must happen so that humans can live well and face death with good preparation. The purpose of this research is to understand the meaning of sakaratul maut according to the book of Syeikh Abidin. This research is a library study. The results show that (a) death is a condition in which the spirit begins to separate from the body, (b) the virtue of remembering death is that it can increase human fear of Allah SWT. So that they can continue to prepare for death, (c) the sense of Sakaratul is divided into three stages of disaster, the testimony of the angel of death, which can cause feelings of horror and fear in the heart for a year, like those who commit immorality, who witness hell, and where they are very afraid. the dark places are full of worms, and the conditions that people receive are according to their deeds in the world.

Abstrak: Setiap yang hidup hidup pasti mati. Kematian harus dipahami sebagai sesuatu yang pasti terjadi agar manusia dapat hidup dengan baik dan menghadapi kematian dengan persiapan yang matang. Tujuan dari penelitian ini adalah untuk memahami pengertian sakaratul maut menurut dalam kitab Syeikh Abidin. Penelitian ini merupakan studi kepustakaan.. Hasil penelitian menunjukkan bahwa (a) kematian adalah keadaan dimana ruh mulai terpisah dari jasad, (b) keutamaan mengingat kematian adalah dapat meningkatkan rasa takut manusia kepada Allah SWT. Agar mereka dapat terus mempersiapkan kematian, (c) rasa Sakaratul dibagi menjadi tiga tahap bencana, yaitu rasa sakit yang begitu mengerikan ketika nyawa dicabut, kesaksian malaikat maut, dan kondisi yang diterima manusia sesuai dengan perbuatan mereka di dunia.
BID’AH DALAM KEHIDUPAN BERKELUARGA MENURUT KITAB AL HABIB USMAN BIN ABDULLAH BIN ‘AQIL BIN YAHYA
Authors: Triwahyuni Firly , Niken Niken , Asvania Selvy , Utami Tera 
Published: October 2023

Abstract: The difference in understanding among Muslims is a social and historical reality that has been going on since the first time after the death of Rasulullah SAW. This is caused by the conflict of interpretation in understanding religious texts. One of the religious terms that is always popular in modern times, namely "Bid'ah". In Indonesia, bid'ah is often a topic of prolonged religious polemic that has no resolution. Moreover, bid'ah has become a daily habit and a hereditary tradition that is difficult to get rid of. This study aims to determine heresy in family life, especially from marriage to childbirth. The method used is qualitative through a literature study using the book Al Habib Usman bin Abdullah bin 'Aqil bin Yahya and various literature.

Abstrak: Perbedaan pemahaman di antara umat Islam merupakan realitas sosial dan sejarah yang telah berlangsung sejak dulu setelah Rasulullah SAW wafat. Hal ini disebabkan oleh adanya konflik interpretasi dalam memahami naskah-naskah keagamaan. Salah satu istilah keagamaan yang senantiasa populer di zaman modern ini, yaitu “Bid’ah”. Di Indonesia sendiri, bid’ah sering kali menjadi topik polemik keagamaan berkepanjangan yang tiada penyelesaiannya. Apalagi bid’ah telah menjadi kebiasaan sehari-hari dan tradisi turun-temurun yang sulit untuk dihilangkan. Penelitian ini bertujuan untuk mengetahui bid’ah-bid’ah dalam kehidupan berkeluarga khususnya dari menikah hingga melahirkan. Metode yang digunakan, yaitu kualitatif melalui studi kepustakaan yang menggunakan kitab Al Habib Usman bin Abdullah bin ‘Aqil bin Yahya dan berbagai literatur. Dapat disimpulkan bahwa bid’ah yang terjadi di Indonesia merupakan hasil turun-temurun yang disebabkan oleh lemahnya pemahaman masyarakat terhadap agama islam.
PROBLEMATIKA PERBEDAAN LATAR BELAKANG MAHASISWA DI PRODI PSIKOLOGI ISLAM FDKI IAIN SAS BANGKA BELITUNG
Authors: Tsana Al-Fiyyah 
Published: October 2023

This research examines the problems of different backgrounds of students in the Islamic psychology study program, Faculty of Da’wah and Islamic Communication, Syaikh Abdurrahman Siddik Islamic Institute, Bangka Belitung. This research aims to describe the background and explain the problems that occur in the lecture process at the Islamic psychology study program, Faculty of Da’wah and Islamic Communication, Syaikh Abdurrahman Siddik Islamic Institute, Bangka Belitung. This type of research is qualitative research. Data collection techniques are interviews, observation and documentation. This study concludes that the difference between one individual or group and another lies in the differences in traditions that have been passed down from generation to generation by the local community. In responding to the differences in the cultural background of each individual, cultural awareness is needed. This is because of the frequent differences in cultural backgrounds that cause conflicts in society
misoprostol como fármaco abortivo: el proceso de co-construcción de su posología
Authors: Mateo Natacha 
Published: October 2023

En la actualidad, el misoprostol es la droga recomendada por la Organización Mundial de la Salud para realizar abortos de forma segura y ambulatoria. En este artículo exploraremos la controversia en torno al proceso de co-construcción de sus indicaciones como droga abortiva en Argentina durante la década del 2000. A diferencia de otros países latinoamericanos, sus primeros usos como inductor contráctil en el campo de la gastroenterología no se habían realizado para este tipo de prácticas. Proponemos una estrategia metodológica diversificada que incorpora no solo los discursos, sino también las prácticas de los actores involucrados en el período analizado a partir del análisis de fuentes escritas y entrevistas en profundidad.
A partir de una problematización de la búsqueda de una posología efectiva del misoprostol desde la perspectiva de la construcción social de la tecnología, proponemos una serie de discusiones en torno de la evidencia científica y las indicaciones por parte de los/as profesionales de la salud, las mujeres que utilizaron la medicación y el movimiento feminista. A diferencia de la propuesta analítica de visiones lineales de la innovación tecnológica, en este artículo indagamos en la centralidad de estos actores durante la década analizada en la controversia en torno de una posología efectiva del misoprostol como droga abortiva.
O Legado do COVID-19: Uma análise das principais complicações e sequelas
Authors: Carneiro Maria Fernanda Salles , Sarto Livia Legati , Miranda Renata Pinto Ribeiro 
Published: October 2023

Introdução: A COVID-19 é uma infecção respiratória aguda causada pelo vírus SARS-CoV-2 e representa um grande problema de saúde em enfrentamento na atualidade, podendo cursar desde quadros leves até a morte. Indivíduos que apresentam quadro clínico com maior comprometimento podem ter sequelas diversas. Objetivo: Descrever as principais complicações e sequelas associadas ao quadro pós-COVID-19. Métodos: Trata-se de uma revisão da literatura que utilizou dados das bases Pubmed e LILACS, limitados no período de 2019 a 2023. A busca foi feita a partir do cruzamento dos descritores “COVID longa”, “COVID-19” e “SARS-CoV-2” de acordo com o DeCS para responder à questão formulada através da estratégia PICO. Resultados e Discussão: A síndrome pós-COVID (SPC) representa a sintomatologia presente após a infecção aguda pelo vírus do COVID-19, sendo a condição definida a partir de 4 semanas ou 3 meses após o início dos sintomas, a depender das determinações das autoridades de saúde. Da mesma forma que a doença aguda, a SPC afeta diversos sistemas, mas de forma tardia, sendo aqui retratadas as sequelas relacionadas aos sistemas respiratório, cardiovascular, nervoso e musculoesquelético, envolvendo complicações como pneumonia, fibrose pulmonar e cardíaca, miocardite, problemas cognitivos, fadiga, ansiedade, depressão e mialgias. Conclusão: Simultaneamente, o SARS-CoV-2 tem ações pulmonares e extrapulmonares e, como as complicações tardias ainda são objetos de estudo recentes, os resultados ainda divergem em muitos pontos. Assim, faz-se necessário o desenvolvimento de mais pesquisas para o estabelecimento de um consenso.
Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model
Authors: Ko Eunkyung Clare , Spitz Sarah , Pramotton Francesca Michela , Barr Olivia M. , Xu Ciana , Pavlou Georgios , Zhang Shun , Tsai Alice , Maaser-Hecker Anna , Jorfi Mehdi , Choi Se Hoon , Tanzi Rudolph E. , Kamm Roger D. 
Published: October 2023

High failure rates in clinical trials for neurodegenerative disorders such as Alzheimer’s disease have been linked to an insufficient predictive validity of current animal-based disease models. This has created an increasing demand for alternative, human-based models capable of emulating key pathological phenotypes in vitro. Here, a three-dimensional Alzheimer’s disease model was developed using a compartmentalized microfluidic device that combines a self-assembled microvascular network of the human blood-brain barrier with neurospheres derived from Alzheimer’s disease-specific neural progenitor cells. To shorten microfluidic co-culture times, neurospheres were pre-differentiated for 21 days to express Alzheimer’s disease-specific pathological phenotypes prior to the introduction into the microfluidic device. In agreement with post-mortem studies and Alzheimer’s disease in vivo models, after 7 days of co-culture with pre-differentiated Alzheimer’s disease-specific neurospheres, the three-dimensional blood-brain barrier network exhibited significant changes in barrier permeability and morphology. Furthermore, vascular networks in co-culture with Alzheimer’s disease-specific microtissues displayed localized β-amyloid deposition. Thus, by interconnecting a microvascular network of the blood-brain barrier with pre-differentiated neurospheres the presented model holds immense potential for replicating key neurovascular phenotypes of neurodegenerative disorders in vitro.
3D-printed custom implant for the management of “locked” posterior dislocation of the shoulder joint with reverse Hill-Sachs lesion: a case report
Authors: Hu Yongrong , Yang Kunhai , Liu Hao , Wang Liping , Wang Song , Zhang Xiang , Qu Bo , Yang Hongsheng 
Published: October 2023

Introduction: Irregular bone defects of the humerus are common in clinical practice, but there are fewer reported cases of irregular humeral defects accompanied by shoulder joint “locking” dislocation and reverse Hill-Sachs injury caused by an electric shock. The choice of treatment for such cases is closely related to the extent of shoulder joint function recovery. This is a case report of a 60-year-old male patient who suffered from a shoulder joint “locking” dislocation with accompanying reverse Hill-Sachs injury due to muscle contraction after being electrically shocked at work. The patient was treated with a 3D-printed custom humeral head prosthesis for the treatment of the shoulder joint “locking” dislocation and reverse Hill-Sachs injury.Case presentation: A 60-year-old male patient, working as a construction worker, presented to our emergency department with right shoulder pain and restricted movement for more than 30 min after an electric shock. Right humeral CT revealed a comminuted fracture of the right humeral head. D-dimer levels were significantly elevated at 3239.00 ng/mL, and oxygen partial pressure was slightly decreased at 68 mmHg. Treatment included emergency wound debridement and dressing for the electrical injury, cardioprotective measures, anticoagulation, and symptomatic management. After stabilizing the patient’s condition, the patient underwent 3D-printed custom prosthesis-assisted partial replacement of the right humeral head and rotator cuff repair in the orthopedic department. Postoperatively, the patient’s right shoulder joint wound healed well, and mobility was restored.Conclusion: This case report demonstrates that the use of a 3D-printed custom prosthesis for the treatment of irregular humeral bone defects caused by specific injury mechanisms, especially cases involving shoulder joint “locking” dislocation and reverse Hill-Sachs injury, can achieve precise bone defect repair, minimize surgical trauma, and provide superior outcomes in terms of postoperative functional rehabilitation.
Modified gefitinib conjugated Fe3O4 NPs for improved delivery of chemo drugs following an image-guided mechanistic study of inner vs. outer tumor uptake for the treatment of non-small cell lung cancer
Authors: Thangudu Suresh , Tsai Ching-Yi , Lin Wei-Che , Su Chia-Hao 
Published: October 2023

Gefitinib (GEF) is an FDA-approved anti-cancer drug for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC). However, the efficacy of anticancer drugs is limited due to their non-specificity, lower accumulation at target sites, and systemic toxicity. Herein, we successfully synthesized a modified GEF (mGEF) drug and conjugated to Iron oxide nanoparticles (Fe3O4 NPs) for the treatment of NSCLC via magnetic resonance (MR) image-guided drug delivery. A traditional EDC coupling pathway uses mGEF to directly conjugate to Fe3O4 NPs to overcom the drug leakage issues. As a result, we found in vitro drug delivery on mGEF- Fe3O4 NPs exhibits excellent anticancer effects towards the PC9 cells selectively, with an estimated IC 50 value of 2.0 μM. Additionally, in vivo MRI and PET results demonstrate that the NPs could accumulate in tumor-specific regions with localized cell growth inhibition. Results also revealed that outer tumor region exhibiting a stronger contrast than the tinner tumor region which may due necrosis in inner tumor region. In vivo biodistribution further confirms Fe3O4 NPs are more biocompatible and are excreated after the treatment. Overall, we believe that this current strategy of drug modification combined with chemical conjugation on magnetic NPs will lead to improved cancer chemotherapy as well as understanding the tumor microenvironments for better therapeutic outcomes.
Association between lipoprotein(a) and insulin resistance in Chinese adults: results from the China health and nutrition survey
Authors: Wang Heng , Fan Jia-Li 
Published: October 2023

BackgroundLipoprotein(a) [Lp(a)] is a well-established risk factor for cardiovascular diseases. However, the relationship between Lp(a) and insulin resistance (IR) remains controversial. The aim of the current study was to investigate the association between Lp(a) concentrations and IR in Chinese adults.MethodsCross-sectional study of 1908 cases and 5725 controls was performed for identifying the association of Lp(a) with IR. IR was assessed using the triglyceride glucose (TyG) index, and patients with a TyG index greater than the third quartile were defined as having IR.ResultsThe distribution of Lp(a) in Chinese adults was skewed, with a median of 7.90mg/dL. Lp(a) concentrations were significantly and progressively lower with increasing TyG index values in Chinese adult males, but not in females. Multiple regression analysis adjusted for a wide range of risk factors showed that Lp(a) concentrations were inversely and independently associated with IR in Chinese adult males, but not in females. The suggested Lp (a) cutoff for discriminating IR from non-IR was 4.7 mg/dL in Chinese adult males. Lp(a) interacts with gender in IR on both additive and multiplicative scale in Chinese adults.ConclusionLp(a) concentrations inversely associated with IR in Chinses adult males, but the association in women needs further study. In Chinese adults, Lp(a) interacts with gender in IR.
Inflammatory arthritis and eye diseases: a Mendelian randomization study
Authors: Nie Xinlin , Liu Zhaoliang , Xie Dongheng , Sun Yang 
Published: October 2023

ObjectivesThe aim of this study was to determine causal associations between inflammatory arthritis and eye diseases (disorders of sclera, cornea, iris, and ciliary body [DSCIC] and disorders of choroid and retina [DCR]).MethodsGenome-wide association studies’ summary data of rheumatoid arthritis (RA) from a large-scale meta-analysis were used to identify genetically predicted RA. UK Biobank source data predicted ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). Furthermore, data from the FinnGen Biobank were used to identify genetically predicted eye diseases. Two-sample Mendelian randomization analysis was used to assess the causal relationship between inflammatory arthritis and eye diseases in the European population. Inverse-variance weighting (IVW) was used as the primary method, while MR-Egger, weighted median, and MR-PRESSO outlier test were used to detect heterogeneity and pleiotropy.ResultsGenetically determined RA was indeed observed to have a causal effect on DSCIC (odds ratio [OR] = 1.084, p = 2.353 × 10−10) and DCR (OR = 1.151, p = 1.584 × 10−19). AS was causally associated with DSCIC (OR = 1.068, p &lt; 2.024 × 10−8). In addition, PsA was also found to have a causal association with an increased risk of 17.9% for the development of DSCIC (OR = 1.179, p = 0.003). On the flip side, DSCIC increased the risk of JIA (OR = 2.276, p = 0.003).ConclusionOur study provided genetic evidence for the causal associations of RA, AS, and PsA with an increased risk of DSCIC, and a causal association between RA and DCR was also identified. In addition, DSCIC greatly increased the risk of JIA.
Occurrence and ecological risk assessment of antibiotics in manure and the surrounding soil from typical chicken farms in Hangzhou, China
Authors: Zha Yan , Li Qinghai , Liu Hang , Ge Ying , Wei Yinghui , Wang Huanhuan , Zhang Lei , Fan Jinghui , Chen Yi , Zhang Chengxian , Zhou Tiefeng , Zhang Weiwu 
Published: October 2023

The widespread use of antibiotics in animal and human medication has raised global concerns over environmental contamination caused by antibiotic residues. This research investigated the occurrence of 12 kinds of antibiotics belonging to three groups, sulfonamides (SAs), tetracyclines (TCs), and fluoroquinolones (FQs), in chicken manure and the surrounding soil from different chicken farms in Hangzhou, South China, were detected in the samples via ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) and the contamination characteristics of each type of antibiotic and the correlations between each antibiotic and environmental factors were analyzed to identify the key influencing factors. An ecological risk assessment of antibiotics in the soil environment was conducted using the risk quotient (RQ) method to analyze the potential hazard level. The results indicated that: the total concentration of FQs was much higher than those of SAs and TCs in chicken manures and the soil samples. The mean concentration of FQs (39.17 μg·kg–1), TCs (34.37 μg·kg–1), and SAs (20.24 μg·kg–1) in chicken manure were significantly higher than those in the soil samples. Ciprofloxacin (CIP) was the main antibiotics detected in manure (19.42 μg·kg–1) and the soils samples (near soil: 18.42 μg·kg–1, far soil: 10.29 μg·kg–1), followed by enrofloxacin (ENR), tetracycline (TC), and ofloxacin (OFL). The redundancy analysis (RDA) showed that moisture content (MS), total organic carbon (TOC) and total nitrogen (TN) had a greater influence on the antibiotic concentration in the soil samples. Basis on the calculated risk quotient (RQs) values, the risk assessment indicated Sulfamerazine (SD) and Sulfamethoxazole (SMX) in soil posed a high risk, while trimethoprim (TMP), TC, CIP, and OFL in soils posed a medium or low risk. This research provides control and environmental monitoring data about chicken farms and scientific information that can be used to alleviate antibiotics pollution.
Knowledge, attitude, and practice of coral reef conservation among Terengganu community of Malaysia
Authors: Marzo Roy Rillera , Chen Hana W. Jun , Anuar Haryati , Abdul Wahab Mohamad Khairuddin , Arifin Mohamad Hairul Nizam , Ariffin Indang Ariati , Hamzah Hazian , Ahmad Azral Ismawy , Kawuki Joseph , Halim Shariff , Aljuaid Mohammed 
Published: October 2023

Background: Malaysia’s coral reefs, primarily threatened by overfishing, pollution, and climate change, face significant challenges despite conservation efforts. Researchers from Management and Science University have taken a holistic approach towards coral reef conservation. This multi-stakeholder strategy, which involves local communities, government agencies, and private sectors, underscores the importance of collective action. A notable initiative within this approach is the coral transplantation program on Geluk Island, aiming to restore and bolster these crucial marine ecosystems.Objective: This study aimed to investigate the knowledge, attitudes, and practices of the Terengganu community towards coral reef conservation and identify sociodemographic variables associated with community member practices.Methodology: This was a cross-sectional study conducted from July to October 2022 in Setiu, Terengganu and recruited 338 adult local villagers. Data on participants’ sociodemographic characteristics, knowledge of coral reefs, awareness and attitude towards the MYCoral 5.0 MSU Eco-Marine Project, and practice of coral reef conservation were collected via validated interviewer-rated questionnaires. Logistic regression analysis was conducted to identify factors associated with good coral reef conservation practices, using SPSS version 2.Results: Out of the 338 participants, 55.3% had acceptable knowledge on coral reefs, 29.0% had good practice of coral reef conservation. Additionally, 44.7% had good knowledge of the MyCoral 5.0 project, and 68.9% were willing to volunteer for coral reef conservation. Knowledge of coral reefs (AOR = 1.22, 95% CI: 1.15–2.52), knowledge of MyCoral project (AOR = 2.64, 95% CI: 1.47–4.74), and willingness to volunteer for conservation (AOR = 1.66, 95% CI: 1.36–3.64) were significantly associated with good practice of coral reef conservation.Conclusion: The study results highlight a need for education and awareness programs to improve the knowledge and practices of coral reef conservation. Moreover, consideration of socio-demographic dynamics of the local communities in designing targeted conservation strategies could also be vital.