bluuebunny/crossref_metadata_2025_split huggingface dataset:
Striae distensae of pregnancy. An in vivo biomechanical evaluation
Authors: Henry Frédérique , Piérard‐Franchimont Claudine , Pans Alain , Piérard Gérald E. 
Published: November 2003

Abstract Background and objective Striae distensae of pregnancy is a common finding. There is currently a lack of information about the rheological characteristics of such lesions. The purpose of this study was to compare the mechanical properties of striae distensae before and after delivery. Patients and methods A total of 79 primigravid entered the study. Rheological properties of skin were evaluated in vivo using a Cutometer® equipped with a 2‐mm probe. Results Mechanical properties of striae distensae developing during pregnancy resembled those of the surrounding skin. By contrast, significant differences were yielded during post‐partum. Extensibility of striae distensae was increased although parameters of elasticity remained normal. Conclusions Rheological properties of striae distensae of pregnancy vary in time. This might reflect the changes in hormones and in the mechanical stresses normally setting the skin under tension.
Mikrographisch kontrollierte Chirurgie (3D‐Histologie) beim Melanom
Authors: Möhrle Matthias 
Published: November 2003

ZusammenfassungDie mikrographisch kontrollierte Chirurgie (3D‐Histologie) wird im englischen Sprachraum nach ihrem Begründer Frederic E. Mohs überwiegend als Mohs Micrographic Surgery (MMS) bezeichnet. Methoden der 3D‐Histologie kamen bislang bei verschiedenen Hauttumoren zum Einsatz. Die 3D‐Histologie ist indiziert bei Tumoren, die sich per continuitatem ausbreiten. Exzisionen mit 3D‐Histologie erfolgen mit primär kleineren Sicherheitsabständen. Hierbei können gesundes Gewebe geschont und bessere kosmetische Ergebnisse erzielt werden.Verschieden Verfahren der 3D‐Histologie, wie die Technik nach Mohs (MMS) und die „Tübinger Torte”, werden im Vergleich zur konventionellen histopathologischen Aufarbeitung vorgestellt. Der Stellenwert der 3D‐Histologie beim Melanom wird anhand der bisher publizierten Arbeiten diskutiert.Auch wenn prospektiv‐randomisierte Untersuchungen zur 3D‐Histologie beim Melanom fehlen, sollte die 3D‐Histologie bei Lentigo‐maligna‐Melanomen grundsätzlich eingesetzt werden. An funktionell bedeutsamen Arealen (Gesicht, Hand, Fuß) ist bei reduzierten Sicherheitsabständen der Einsatz der 3D‐Histologie auch bei anderen histologischen Melanomtypen sinnvoll.
Use of terbinafine for tinea in Australian Aboriginal communities in the Top End
Authors: Koh Karen J , Parker Colin J , Ellis David H , Pruim Bert , Leysley Loyla , Currie Bart J 
Published: November 2003

SUMMARYTinea of the skin and nails is a common problem in remote Aboriginal communities of the Top End of Australia. A retrospective study was performed on data collected from 104 patients from several indigenous communities. Worksheets were filled in by district medical officers and rural general practitioners, detailing the extent of the tinea. Patients were prescribed between 4 and 12 weeks of 250 mg daily oral terbinafine. Fifty‐two patients were followed up, with 45 having a good response to treatment (87%) and with 22 of these patients having full clearance of tinea (42%).A prospective study with 44 subjects was performed. The extent of the tinea was documented and fungal scrapings/clippings were taken. Forty subjects were recruited and given oral terbinafine (2–12 weeks depending on skin/nail involvement) or topical terbinafine if oral treatment was contraindicated. Twenty‐five of the 40 (63%) subjects were reviewed. Twenty‐three (92%) subjects that were followed up improved clinically, with 8/25 (32%) clearing completely. Twenty (80%) of followed‐up patients complied fully with treatment. Terbinafine was found to be a well‐tolerated and effective treatment of tinea of the skin and nails.
Multiple trichoepitheliomas in a mother and daughter
Authors: Crotty Kerry , Dutta Bishnu , Hogan Peter 
Published: November 2003

SUMMARYA 38‐year‐old mother and her 8‐year‐old daughter presented with multiple facial papules. In both cases, the papules had started to develop at about the age of 4–5 years. Biopsy of one of the mother's papules revealed a trichoepithelioma. With time the lesions had become less obvious in the mother, so she and her daughter elected to have no treatment. Both mother and daughter were otherwise well. However, there have been rare reports of multiple trichoepitheliomas being associated with systemic conditions. Multiple trichoepitheliomas are inherited in an autosomal dominant manner and have been mapped to chromosome 9p21.
Porokeratosis of Mibelli: Successful treatment with topical 5% imiquimod cream
Authors: Harrison Shannon , Sinclair Rodney 
Published: November 2003

SUMMARYA 77‐year‐old woman with a large porokeratosis of Mibelli on the left shin was successfully treated with topical 5% imiquimod cream applied to the entire lesion once daily without occlusion three times a week. A strong inflammatory reaction was achieved in 6 weeks of treatment. The lesion had been present for approximately 6 years and prior treatments included curettage and electrocautery, cryotherapy and topical 5‐fluorouracil under occlusion. At the end of treatment with topical 5% imiquimod cream, punch biopsy was negative for porokeratosis. The lesion healed without scarring. At 24‐month follow up there had been no sign of clinical recurrence.
Necrotizing eosinophilic folliculitis with mucinosis
Authors: Kossard Steven 
Published: November 2003

SUMMARYA 23‐year‐old woman presented with a 2‐week history of an extensive facial eruption consisting of markedly crusted arciform plaques covered with a haemorrhagic eschar that commenced as pruritic follicular pustules. These were associated with facial oedema but no systemic symptoms or fever. Two skin biopsies revealed prominent tissue eosinophilia with eosinophilic folliculitis and areas of follicular mucinosis, as well as haemorrhagic scale crust over the surface. The clinical and histological findings may represent an example of a necrotizing variant of eosinophilic folliculitis that has recently been reported in atopic individuals. This patient, however, did not have evidence of atopy and appeared to have a florid form of Ofuji's disease that responded rapidly to indomethacin treatment.
“Brain Abuse”, or the Devaluation of Immigrant Labour in Canada
Authors: Bauder Harald 
Published: November 2003

Many professional and skilled Canadian immigrants suffer from de‐skilling and the nonrecognition of their foreign credentials. Consequently, they are underrepresented in the upper segments of the Canadian labour market. Rather than accepting this devaluation of immigrant labour as a naturally occurring adjustment period, I suggest that regulatory institutions actively exclude immigrants from the upper segments of the labour market. In particular, professional associations and employers give preference to Canadian‐born and educated workers and deny immigrants access to the most highly desired occupations.Pierre Bourdieu's notion of institutionalised cultural capital and his views of the educational system as a site of social reproduction provide the entry point for my theoretical argument. I find that the nonrecognition of foreign credentials and dismissal of foreign work experience systematically excludes immigrant workers from the upper segments of the labour market. This finding is based on data from interviews with institutional administrators and employers in Greater Vancouver who service or employ immigrants from South Asia and the former Yugoslavia.
Interests, Institutions and Industrial Relations
Authors: Wailes Nick , Ramia Gaby , Lansbury Russell D. 
Published: November 2003

AbstractIn the comparative politics literature there are two main approaches to the impact of international economic change on national policy patterns. The first — new institutionalism — has been very influential in comparative industrial relations scholarship. The second, which focuses on the role of interests, has been less prominent. Comparing industrial relations reform in Australia and New Zealand during the 1980s and 1990s, this paper argues that there are a number of limitations to an institutionalist approach and outlines a framework for the comparative study of the impact of international economic change on national patterns of industrial relations which integrates both institutionalist and interest‐based approaches.
Gendering Industrial Citizenship
Authors: Zetlin Di , Whitehouse Gillian 
Published: November 2003

AbstractIn this paper we analyse the gendered construction of ‘industrial citizenship’ from the model envisaged by Marshall in 1950 to possibilities suggested in ‘Third Way’ thinking. We argue that the Marshallian model, while clearly exclusive to men, provided a framework on to which a more inclusive industrial citizenship could be built, primarily through its recognition of a social component to citizenship. Rather than giving an uncritical endorsement of Marshall's vision, we seek to highlight the benefits for women of viewing citizenship as inclusive of social rights, and the problems associated with dismantling this type of vision of the relationship between citizenship and work.
Regulated binding of the fibrinogen‐like domains of tenascin‐R and tenascin‐C to the neural EGF family member CALEB
Authors: Schumacher Stefan , Stübe Eva‐Maria 
Published: November 2003

AbstractThe neural transmembrane protein CALEB was discovered in a screen for novel molecules implicated in neuronal differentiation processes and was found to bind to two proteins of the extracellular matrix, tenascin‐C and tenascin‐R. The expression of different isoforms of CALEB in axon‐ and synapse‐rich areas in the nervous system is regulated during development. Here we show that an unusual acidic peptide segment of CALEB is sufficient to mediate the binding of CALEB to the fibrinogen‐like globes of both tenascin family members as well as to native tenascin‐C. We idengify a small sequence element within the acidic peptide segment of CALEB as important for this binding. Interestingly, the interactions of CALEB and tenascin‐C and ‐R seem to be regulated during development. We demonstrate that only CALEB‐80, the expression of which is up‐regulated in the chicken retina during synaptogenesis, but not CALEB‐140, expressed later on in development, can bind to the fibrinogen‐like domains of tenascin‐R or tenascin‐C and to native tenascin‐C. While both CALEB‐80 and CALEB‐140 are expressed in the plexiform layers and the optic fiber layer of embryonic chicken retina, CALEB‐140 labeling is more intense in the optic fiber layer in comparison to the inner plexiform layer.
Isolation, characterization and cross‐species amplification of eight microsatellite DNA loci in the migratory locust (Locusta migratoria)
Authors: Zhang De‐Xing , Yan Lu‐Na , Ji Ya‐Jie , Kang Le , Hewitt Godfrey M. , Huang Zu‐Shi 
Published: November 2003

AbstractEight polymorphic di‐ and trinucleotide microsatellite loci suitable for population genetic analysis were developed in Locusta migratoria from a partial phagemid genomic library enriched for microsatellite inserts. The expected heterozygosity at these loci ranges from 0.45 to 0.97, with the observed allele numbers varying between nine and 45. The overall microsatellite cloning efficiency in L. migratoria is 14%, suggesting that in migratory locusts, microsatellite sequences are abundant and should provide a valuable and easily accessible source of nuclear markers for genetic studies. These microsatellite loci were highly Locusta‐specific, with only very limited cross‐species applicability.
Characterization of microsatellite loci isolated from the blacktip shark and their utility in requiem and hammerhead sharks
Authors: Keeney Devon B. , Heist Edward J. 
Published: November 2003

AbstractWe isolated and characterized 16 microsatellite loci from the blacktip shark, Carcharhinus limbatus, and tested cross‐species amplification in 11 Carcharhinus species and five additional shark genera. Thirty‐six (1.6%) and 180 (48%) colonies were positive for dinucleotide repeat motifs from unenriched and enriched libraries, respectively. Heterozygosities of polymorphic loci ranged from 0.04 to 0.96 with two to 22 alleles per locus. Amplification products were observed at nine to 13 loci (five to 11 of which where polymorphic) in 10 Carcharhinus species. Several loci were also polymorphic in each of the additional genera examined.
Isolation and characterization of 16 microsatellite loci in the Great Tit Parus major
Authors: Saladin Verena , Bonfils Danielle , Binz Thomas , Richner Heinz 
Published: November 2003

AbstractSix dinucleotide, three trinucleotide and seven tetranucleotide microsatellite loci developed for the great tit Parus major are presented. Thirty individual birds were screened at each locus. Loci were polymorphic (four to 19 alleles per locus). These markers provide a system to study paternity, genetic diversity in natural populations, gene flow, dispersal and inbreeding.
Primers for the amplification of sequence‐characterized loci in Cryphonectria cubensis populations
Authors: Van Der Merwe N. A. , Wingfield B. D. , Wingfield M. J. 
Published: November 2003

AbstractWe describe the development of DNA markers for the fungal pathogen of Eucalyptus, Cryphonectria cubensis. These markers originated from cloned intershort sequence repeat polymerase chain reactions, which enrich for medium to highly repetitive DNA sequences. In total, 10 markers were isolated, eight of which were polymorphic, and these can subsequently be applied to study populations of C. cubensis.
Isolation and characterization of polymorphic microsatellite markers in the white‐winged chough (Corcorax melanorhamphos)
Authors: Beck N. , Peakall R. , Heinsohn R 
Published: November 2003

AbstractWe have isolated and characterized seven polymorphic microsatellite loci in the white‐winged chough (Corcorax melanorhamphos), a highly social, cooperatively breeding bird of Australian eucalypt woodlands. In analyses of 100 samples from 16 family groups, the number of alleles per locus ranged from four to 18, and observed heterozygosity ranged between 0.46 and 0.93. One locus appears to be sex‐linked. The primers were also tested in apostlebirds (Struthidera cinerea), the only other species in the subfamily Corcoracinae. Five loci were successfully amplified and three were polymorphic.
New microsatellite markers for the snow crab Chionoecetes opilio (Brachyura: Majidae)
Authors: Puebla O. , Parent É. , Sévigny J.‐M. 
Published: November 2003

AbstractFive microsatellite markers were developed for the snow crab (Chionoecetes opilio) and polymerase chain reaction conditions and/or primer sequences of three previously developed microsatellites were adapted for fluorescent labelling analysis. All loci were analysed in 449 individuals from 11 sampling sites in the northwest Atlantic. The high degree of polymorphism exhibited by these microsatellites (mean of 34 alleles per locus and mean observed heterozygosity of 0.76) suggests that they will be suitable for spatial and temporal genetic analysis of C. opilio populations.
Perceived locus of control and satisfaction in same–sex friendships
Authors: Morry Marian M. 
Published: November 2003

AbstractTwo studies examined perceptions of locus of control (LofC) and friendship satisfaction. Study 1 tested the accuracy of college students’ perceptions of a friend's LofC and their friendship satisfaction. Participants perceived their friends to be similar to themselves on LofC and satisfaction but these perceptions did not match the friends’ self–ratings. Instead, the perceptions reflected a belief in the similarity to the self—the Attraction–Similarity Hypothesis. Study 2 tested whether own and perceived friend's LofC predicted own satisfaction. The Internality Hypothesis indicates that an external LofC would predict dissatisfaction but an internal LofC would predict satisfaction. It was also predicted that these effects would be stronger for women's friendships than for men's friendships. For female, but not male, friendships, perceptions of the friend's external LofC predicted dissatisfaction.
Treatment of Helicobacter pylori infection
Authors: Perri Francesco , Qasim Asghar , Marras Lea , O'Morain Colm 
Published: November 2003

ABSTRACTReview of the recently published data on Helicobacter pylori management highlights various interesting aspects. Current H. pylori eradication guidelines generally suggest a noninvasive ‘test and treat’ strategy for all dyspeptic patients with certain age limits depending on the local gastric neoplasia risk. According to the ‘Maastricht 2–2000 Consensus Report’ treatment should be thought of as a ‘package’ considering first‐ and second‐line eradication therapies together. Various centres have published their results using novel antimicrobial formulations and ‘rescue’ and ‘sequential’ therapies. Review suggests that care at the specialist level remains a challenge and guidelines are deficient particularly as regards the selection and duration of eradication therapies. Results indicate that differences for CYP2C19 genotype and the selection of proton pump inhibitors have no significant role in determining eradication rates whereas antibiotic resistance and socio‐economic factors play a variable role according to different geographical areas. Compliance remains an important factor in determining clinical outcome at the primary and secondary levels worldwide.
Pathogenesis of Helicobacter pylori infection
Authors: Lamarque Dominique , M. Peek Richard 
Published: November 2003

ABSTRACT Helicobacter pylori induces persistent inflammation in the human stomach, yet only a minority of colonized persons develop peptic ulcer disease or gastric malignancy. Numerous studies published in the last year have demonstrated that H. pylori isolates possess substantial phenotypic and genotypic diversity, which may engender differential host inflammatory responses that influence clinical outcome. Results from these recent investigations have more precisely delineated the mechanisms of H. pylori pathogenesis, which will ultimately help to define colonized persons bearing the highest risk for disease, and enable physicians to appropriately focus diagnostic testing and eradication therapy.
Dissociated Pulmonary Vein Arrhythmia:
Authors: WEERASOORIYA RUKSHEN , JAÏS PIERRE , SCAVÉE CHRISTOPHE , MACLE LAURENT , SHAH DIPEN C. , ARENTZ THOMAS , SALERNO JORGE A. , RAYBAUD FLORENCE , CHOI KEE‐JOON , HOCINI MÉLÈZE , CLÉMENTY JACQUES , HAÏSSAGUERRE MICHEL 
Published: November 2003

Introduction: The incidence and characteristics of dissociated arrhythmia confined to the pulmonary vein (PV) following disconnection have not been described in a large number of patients with paroxysmal atrial fibrillation. Methods and Results: This was a prospective study of 152 patients (29 female, mean age 51 ± 11 years) referred for catheter ablation of drug‐refractory paroxysmal atrial fibrillation. Following ostial ablation, the rate and regularity of any dissociated venous activity was analyzed with and without isoproterenol infusion (to achieve a heart rate of 120–140 beats/min). Patients then were classified according to their venous dissociated activity. Group 1 consisted of patients in whom the dissociated PV spike had a slow rhythm >1,200 ms. Group 2 consisted of patients with spontaneous repetitive dissociated discharges confined in the vein with a cycle length <400 ms. A total of 384 PVs were ablated in 152 patients. Disappearance of all venous potentials was observed in 88% of the treated veins; at least one dissociated venous potential was observed in the remaining 12%. Group 1 activity was seen more often than group 2 (23 patients, mean cycle length 2,300 ± 1,100 ms vs 13 patients, mean cycle length 179 ± 77 ms). Dissociated PV arrhythmia was seen most often in the right superior PV (19%). Conclusion: Dissociation as the endpoint of PV disconnection was observed in 12% of PVs. Due to the capricious nature of this activity, the actual incidence is almost certainly higher. The dissociated venous rhythm usually is slow and, less commonly, is rapid and repetitive. (J Cardiovasc Electrophysiol, Vol. 14, pp. 1173‐1179, November 2003)
Phosphorylation of
Streptococcus salivarius
Lactose Permease (LacS) by HPr(His∼P) and HPr(Ser-P)(His∼P) and Effects on Growth
Authors: Lessard Christian , Cochu Armelle , Lemay Jean-Dominique , Roy Denis , Vaillancourt Katy , Frenette Michel , Moineau Sylvain , Vadeboncoeur Christian 
Published: November 2003

ABSTRACT

The oral bacterium
Streptococcus salivarius
takes up lactose via a transporter called LacS that shares 95% identity with the LacS from
Streptococcus thermophilus
, a phylogenetically closely related organism.
S. thermophilus
releases galactose into the medium during growth on lactose. Expulsion of galactose is mediated via LacS and stimulated by phosphorylation of the transporter by HPr(His∼P), a phosphocarrier of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS). Unlike
S. thermophilus
,
S. salivarius
grew on lactose without expelling galactose and took up galactose and lactose concomitantly when it is grown in a medium containing both sugars. Analysis of the C-terminal end of
S. salivarius
LacS revealed a IIA-like domain (IIA
LacS
) almost identical to the IIA domain of
S. thermophilus
LacS. Experiments performed with purified proteins showed that
S. salivarius
IIA
LacS
was reversibly phosphorylated on a histidine residue at position 552 not only by HPr(His∼P) but also by HPr(Ser-P)(His∼P), a doubly phosphorylated form of HPr present in large amounts in rapidly growing
S. salivarius
cells. Two other major
S. salivarius
PTS proteins, IIAB
L
Man
and IIAB
H
Man
, were unable to phosphorylate IIA
LacS
. The effect of LacS phosphorylation on growth was studied with strain G71, an
S. salivarius
enzyme I-negative mutant that cannot synthesize HPr(His∼P) or HPr(Ser-P)(His∼P). These results indicated that (i) the wild-type and mutant strains had identical generation times on lactose, (ii) neither strain expelled galactose during growth on lactose, (iii) both strains metabolized lactose and galactose concomitantly when grown in a medium containing both sugars, and (iv) the growth of the mutant was slightly reduced on galactose.
New Bacterial Pathway for 4- and 5-Chlorosalicylate Degradation via 4-Chlorocatechol and Maleylacetate in
Pseudomonas
sp. Strain MT1
Authors: Nikodem Patricia , Hecht Volker , Schlömann Michael , Pieper Dietmar H. 
Published: November 2003

ABSTRACT

Pseudomonas
sp. strain MT1 is capable of degrading 4- and 5-chlorosalicylates via 4-chlorocatechol, 3-chloromuconate, and maleylacetate by a novel pathway. 3-Chloromuconate is transformed by muconate cycloisomerase of MT1 into protoanemonin, a dominant reaction product, as previously shown for other muconate cycloisomerases. However, kinetic data indicate that the muconate cycloisomerase of MT1 is specialized for 3-chloromuconate conversion and is not able to form
cis
-dienelactone. Protoanemonin is obviously a dead-end product of the pathway. A
trans
-dienelactone hydrolase (
trans
-DLH) was induced during growth on chlorosalicylates. Even though the purified enzyme did not act on either 3-chloromuconate or protoanemonin, the presence of muconate cylcoisomerase and
trans
-DLH together resulted in considerably lower protoanemonin concentrations but larger amounts of maleylacetate formed from 3-chloromuconate than the presence of muconate cycloisomerase alone resulted in. As
trans
-DLH also acts on 4-fluoromuconolactone, forming maleylacetate, we suggest that this enzyme acts on 4-chloromuconolactone as an intermediate in the muconate cycloisomerase-catalyzed transformation of 3-chloromuconate, thus preventing protoanemonin formation and favoring maleylacetate formation. The maleylacetate formed in this way is reduced by maleylacetate reductase. Chlorosalicylate degradation in MT1 thus occurs by a new pathway consisting of a patchwork of reactions catalyzed by enzymes from the 3-oxoadipate pathway (catechol 1,2-dioxygenase, muconate cycloisomerase) and the chlorocatechol pathway (maleylacetate reductase) and a
trans
-DLH.