bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytologic, histologic, and clinical correlation of minor mutations in pancreatic cysts
Authors: Kwan Melanie C. , Pitman Martha B. , Zhang M. Lisa 
Published: January 2025

AbstractBackgroundMajor mutations (e.g., KRAS, GNAS, TP53, SMAD4) in pancreatic cyst fluid (PCF) are useful for classifying and risk stratifying certain cyst types, particularly in cases with nondiagnostic cytology. However, the significance of uncommon minor mutations in PCF has yet to be reported.MethodsIn total, 127 PCF specimens (2014–2021) from 121 patients that underwent molecular analysis were identified, and detailed clinicopathologic data were recorded. Molecular testing was performed using a laboratory‐developed next‐generation sequencing panel.ResultsForty‐five variants other than KRAS, GNAS, RNF43, TP53, CDKN2A, and SMAD4 were detected. Variants that were detected in five or more cases included ARID1A (n = 28), VHL (n = 17), BRAF (n = 12), ATM (n = 8), APC (n = 8), MEN1 (n = 5), serine threonine kinase 11 (STK11; n = 5), PIK3CA (n = 5), and CDH1 (n = 5). Thirty‐eight of 121 patients (31%) had histologic confirmation on follow‐up resection. Twenty‐seven of 28 cysts (96%) with ARID1A mutations had concurrent KRAS/GNAS mutations; 17 (61%) were diagnosed as neoplastic mucinous cysts on cytology, and 10 (36%) were diagnosed as intraductal papillary mucinous neoplasm (IPMN) on histology (80% low grade). No patients developed disease recurrence or died of disease. Cysts with STK11 mutations had RAS co‐mutations (KRAS, n = 5; NRAS, n = 1), and four of those five cysts (80%) were mucinous neoplasms with high‐grade atypia on cytology. All three resection specimens were IPMNs with high‐grade dysplasia or invasive carcinoma, and two of those patients died of disease.ConclusionsIn PCFs, ARID1A mutations were consistently associated with IPMNs (predominantly low grade) with no recurrences or deaths from disease. STK11 mutations appeared to be associated with high‐risk mucinous cysts. The detection of minor variants may provide useful preoperative information and add value beyond single‐gene genotyping of major mutations.
A Dynamic Energy‐Efficient Scheduling Method for Periodic Workflows Based on Collaboration of Edge‐Cloud Computing Resources
Authors: Chen Hong , Liu Jianxun , Zhu Zhifeng 
Published: January 2025

ABSTRACTEdge‐cloud computing offers an efficient method to flexibly allocate various computing resources for periodic workflow applications commonly employed in industrial production, commercial operations, and scientific research. Rationalized allocation of computational resources for scheduling in the edge‐cloud environment is the key to reducing energy consumption of the periodic workflows scheduling process. To this end, this paper proposes an optimization method for dynamic energy‐efficient scheduling of periodic workflows based on the collaboration of edge‐cloud computational resources while satisfying the constraints of workflow deadlines. In our method, periodic workflow scheduling is defined to be performed on a three‐tier integrated scheduling architecture of user terminals, edge computing platform, and cloud computing platform. Task groups are generated based on workflow critical paths, and appropriate edge‐cloud computing resources are selected for workflow tasks using corresponding scheduling policies at each scheduling stage. It reduces energy consumption during task scheduling while satisfying workflow deadline constraints. Comparative experiments in a simulated edge‐cloud environment show that our method reduces energy consumption of the scheduling process by 19.38%, 22.7%, and 37.34% compared to GA, PSO, and cloud computing, respectively. That is, the method effectively reduces the scheduling energy consumption during periodic workflow processing and significantly improves computational resource utilization.
Microwave‐Assisted Rapid Hydrothermal Synthesis of Vanadium‐Based Cathode: Unravelling Charge Storage Mechanisms in Aqueous Zinc‐Ion Batteries
Authors: Sariyer Selin , Keppetipola Nilanka M. , Sel Ozlem , Demir‐Cakan Rezan 
Published: January 2025

AbstractThis contribution uses a rapid microwave‐assisted hydrothermal synthesis method to produce a vanadium‐based K1.92Mn0.54V2O5 ⋅ H2O cathode material (quoted as KMnVOH). The electrochemical performance of KMnVOH is tested in an aqueous electrolyte, which exhibits a remarkable specific capacity of 260 mAh g−1 at 5 C and retains 94 % of its capacity over 2000 cycles. In contrast to the aqueous electrolyte, the KMnVOH electrode tested in the organic electrolyte provides a modest discharge capacity of 60 mAh g−1 at C/10, and the electrogravimetric analysis indicates that the charge storage mechanism is solely due to non‐solvated Zn2+ intercalation. In aqueous electrolyte tests, Zn species insertion, interfacial pH increase, and subsequent formation of Znx(OH)y(CF3SO3)2x‐y ⋅ nH2O (ZHT) are supported by in‐situ EQCM. Ex‐situ XRD measurements also confirm the ZHT formation and its characteristic plate‐like structure is observed by SEM. The ion diffusion coefficient values in aqueous and non‐aqueous electrolytes are very similar according to the GITT analysis, while it is expected to be higher in aqueous electrolytes. These results may further emphasize the complex redox dynamics in the aqueous electrolyte, namely the difficulty of intercalation of bare Zn2+, strong Zn2+ solvation in the bulk electrolyte, solvent or proton intercalation, and ZHT formation.
Boosting Light‐Driven CO2 Conversion Into CO by a Polypyridine Iron(II) Catalyst Using an Organic Sensitizer
Authors: Droghetti Federico , Villa Lucrezia , Sartorel Andrea , Dell'Amico Luca , Ruggi Albert , Natali Mirco 
Published: January 2025

AbstractDirect photochemical conversion of CO2 into a single carbon‐based product currently represents one of the major issues in the catalysis of the CO2 reduction reaction (CO2RR). In this work, we demonstrate that the combination of an organic photosensitizer with a heptacoordinated iron(II) complex allows to attain a noble‐metal‐free photochemical system capable of efficient and selective conversion of CO2 into CO upon light irradiation in the presence of N,N‐diisopropylethylamine (DIPEA) and 2,2,2‐trifluoroethanol (TFE) as the electron and proton donor, respectively, with unprecedented performances (ΦCO up to 36 %, TONCO >1000, selectivity >99 %). As shown by transient absorption spectroscopy studies, this can be achieved thanks to the fast rates associated with the electron transfer from the photogenerated reduced dye to the catalyst, which protect the dye from parallel degradation pathways ensuring its stability along the photochemical reaction. These results point out how the profitable merging of molecular species based on cheap and abundant elements can have great potential to target efficient and selective transformations crucial for the conversion of solar energy into fuels.
Diagnosing Broken Rotor Bar Faults in Speed‐Sensorless Squirrel Cage Induction Motors Using Principal Component Analysis and Knowledge Graph
Authors: Bai Xusong , Song Xiangjin , Wang Zhaowei , Zhao Wenxiang , Chen Qian 
Published: January 2025

ABSTRACTSquirrel cage induction motors (SCIMs) are integral to numerous industrial applications, and the accurate monitoring and diagnosis of rotor bar conditions are paramount for enhancing system productivity and minimizing maintenance expenditures. However, the existing techniques for diagnosing broken rotor bars (BRBs) faults are often constrained by the voltage imbalance conditions and the low slip in practical applications. This paper introduces an innovative approach to BRBs fault diagnosis, using principal component analysis (PCA) and knowledge graph (KG) methodologies. PCA, which is robust to imbalanced conditions, is employed to demodulate the stator current signals and isolate the phase modulation (PM) component. The calculated PM index serves as a fault indicator. Concurrently, the KG framework is introduced to detect the BRB fault and quantify the severity. Experimental results demonstrate the effectiveness and reliability of the proposed method under different load levels and fault severities.
IoT Integration With CMPA‐PINN for Islanding Detection Through Microgrid Hierarchical Control
Authors: Komala C. R. , Jeyakumar S. , Deepika G. , Swaroopa K. , Rangaree Pankaj , Arif Mohammad , Saikia Bhargabjyoti , BalaSubramanyam P. N. V. 
Published: January 2025

ABSTRACTInternet of Things (IoT) and cloud computing are becoming increasingly important in the solution of many industrial problems. Effective management of microgrid (MG) requires a strong and scalable information and communication technology (ICT) infrastructure. IoT devices with effective measurement and control capabilities have the potential to be very important in the MG environment. MG was run in both grid‐connected and island mode. This paper proposes to improve the MG hierarchical control with IoT using CMPA‐PINN techniques for islanding detection. The proposed hybrid method is the joint execution of both the Coronavirus Mask Protection Algorithm (CMPA) and physics‐informed neural networks (PINNs). Hence, it is named as CMPA‐PINN approach. The major goal of this proposed method is to reduce the deviation of voltage, frequency, and total harmonic distortion (THD). The proposed CMPA is used to optimize the traffic flow over a communication network, and the PINNs are used to predict the optimized traffic flow. By then, the MATLAB platform has adopted the proposed method, and the current process is used to compute its execution. The proposed technique outperforms all current systems, including maximum power point tracking (MPPT), multi‐agent reinforcement learning (MARL), and deep reinforcement learning (DRL). The proposed approach shows the THD is 2%, which is lower than other existing systems.
Improving Smallholder Maize Production in KwaZulu‐Natal, South Africa
Authors: Ono‐Raphel Joe G. , du Preez Lisa , Cherry Audie L. , Jacobson Michael G. 
Published: January 2025

ABSTRACTMaize production contributes to food security and economic stability among smallholder farmers in the KwaZulu‐Natal (KZN) province of South Africa, but it faces major challenges. Obstacles in smallholder maize production include limited water supplies, soil degradation, and biotic stressors such as pests and diseases. This study uses a case study methodology incorporating primary observations, secondary referencing, and literature reviews to examine the intricate relationship between smallholder maize production and agricultural/natural resources. The recommendations offered here focus on improving food security in KZN, including the integration of scientific and indigenous knowledge systems, farmer participation in decision‐making processes, and the provision of educational programs tailored to smallholder farmers. Taken together, these recommendations can help strengthen smallholder participation in maize production in KZN.
Structural Variant Analysis of Complex Karyotype Myelodysplastic Neoplasia Through Optical Genome Mapping
Authors: Valkama Andriana , Vorimo Sandra , Tervasmäki Anna , Räsänen Hannele , Savolainen Eeva‐Riitta , Pylkäs Katri , Mantere Tuomo 
Published: January 2025

ABSTRACTMyelodysplastic neoplasia with complex karyotype (CK‐MDS) poses significant clinical challenges and is associated with poor survival. Detection of structural variants (SVs) is crucial for diagnosis, prognostication, and treatment decision‐making in MDS. However, the current standard‐of‐care (SOC) cytogenetic testing, relying on karyotyping, often yields ambiguous results in cases with CK. Here, SV detection by novel optical genome mapping (OGM) technique was explored in 15 CK‐MDS cases, which collectively harbored 85 chromosomes with abnormalities reported by SOC. Additionally, OGM was utilized in the discovery of novel SVs. Altogether, OGM detected corresponding > 5 Mbp alterations for 73 out of 85 SOC reported abnormalities, resulting in an 86% concordance rate. OGM provided further specification of these abnormalities, revealing that 64% of the altered chromosomes were affected by multiple SVs or chromoanagenesis. Prominently, only 5% of missing chromosomes reported by SOC were true monosomies. In addition, OGM detected alterations in chromosomes not reported as abnormal by karyotyping in 93% of cases and provided clinically relevant gene‐level information, such as SVs in TP53, MECOM, NUP98, IKZF1, and ETV6. Analysis of novel SVs revealed two previously unreported gene‐fusions (SCFD1::ZNF592 and VPS8::LRBA), both confirmed by transcriptome sequencing. Furthermore, the repositioning of CCDC26 (8q24.21) was identified as a potential cause of inappropriate gene activation in two cases, affecting MECOM and SOX7, respectively. This study shows that OGM can significantly enhance the diagnostic analysis of SVs in CK‐MDS and highlights the utility of OGM identifying novel SVs in complex cancer genomes.
Nickel Aluminum Spinel Derived Ni‐F‐Al Active Site for the Catalytic Dehydrofluorination of Potent Greenhouse Gas 1,1,1,2‐Tetrafluoroethane
Authors: Liu Fangcao , Liu Bing , Sun Yiwei , Liu Jinru , Bi Yubao , Zhao Jiaming , Wei Xiaoli , Han Wenfeng 
Published: January 2025

ABSTRACTHFC‐134a (1,1,1,2‐tetrafluoroethane) is one of the most common refrigerants with global warming potential (100 years) of 1300. It is regulated to be phased out gradually according to the Kigali Amendment to the Montreal Protocol. Treatment of this stable chemical poses significant challenge. Highly efficient nickel aluminum spinel catalysts were fabricated by sol–gel method for the catalytic dehydrofluorination of HFC‐134a. The effect of Ni/Al ratio in the NiAl2O4 spinel precursors on the performance of NiAl catalysts was studied by x‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), scanning electron microscope (SEM), transmission electron microscopy (TEM), NH3‐TPD, and XPS. Nickel–aluminum ratio in the nickel–aluminum spinel precursor plays a major role on the formation of strong acid and active species Ni‐F‐Al. With Ni/Al ratio of 4, the (3 1 1) crystal face of NiAl2O4 interfaced with the (1 1 1) crystal face of NiO and the (4 0 0) crystal face of NiAl2O4. This interaction facilitates the formation of Ni‐F‐Al active species following the dehydrofluorination reaction. Furthermore, the Ni‐F‐Al species altered the acid structure of NiAl catalysts. It was found that NiAl catalyst with a Ni/Al ratio of 4 has the best catalytic performance compared with other catalysts (with conversion of 35%), and no deactivation trend was observed after 50 h of time on stream. (Reaction conditions: N2/CF3CH2F = 10, T = 450°C, GHSV = 660 h−1).
Shift‐and‐Persist Strategies and Psychological Well‐Being: Where Adolescents Stand on Social Ladder Matters
Authors: Chen Lihua , Lin Weijie , Zhao Shan , Chi Peilian 
Published: January 2025

ABSTRACTObjectivesShift‐and‐persist coping strategies have been demonstrated to be beneficial for physical health of individuals in low socioeconomic status (SES); however, their impacts on psychological well‐being remain less clear. This study aimed to examine: (1) whether the protective effects of shift‐and‐persist with respect to psychological well‐being (i.e., depressive symptoms and subjective well‐being) only exist among adolescents with lower (vs. higher) subjective SES, and (2) what drives the potential benefits, shifting strategy or persisting strategy, or both of them?MethodsThis study recruited 686 middle school students (54.5% male; Mage = 12.57 years, SD = 0.65) from Guangdong Province, China, in January 2019, and they completed measures of subjective SES (i.e., perceived family social status), shift‐and‐persist strategies, depressive symptoms, subjective well‐being, and demographic information.ResultsAdolescents who engaged in more shift‐and‐persist strategies reported fewer depressive symptoms and higher levels of subjective well‐being, with stronger effects among those lower (vs. higher) in subjective SES. When further exploring what drove these effects, results showed that persisting strategy was associated with fewer depressive symptoms and higher levels of subjective well‐being, with more pronounced effects for adolescents with lower (vs. higher) subjective SES. The shifting strategy was associated with fewer depressive symptoms only among those with lower subjective SES, while associated with higher levels of subjective well‐being regardless of subjective SES levels.ConclusionsFindings support the applicability of the shift‐and‐persist model to both positive and negative indicators of psychological well‐being and enrich the theory by providing preliminary evidence for the domain‐specific roles of shifting strategy in buffering the negative psychological effects of low‐SES contexts.
Molecular insights into the unique properties of the blood‐circulating proteasome
Authors: Leushkin Yegor , Morgenstern David , Ben‐Dor Shifra , Haffner‐Krausz Rebecca , Zittlau Katharina , Ben‐Nissan Gili , Sharon Michal 
Published: January 2025

AbstractProteasomes are essential for protein degradation and maintaining cellular balance, yet their roles in extracellular fluids are not well understood. Our study investigates the freely circulating proteasome in blood, to uncover its unique molecular characteristics, compared to its intracellular counterparts. Using a transgenic mouse model, mass spectrometry, and biochemical tools, we show that the predominant proteasome in serum is the free uncapped 20S particle, which seems to assemble intracellularly before entering the bloodstream. This serum proteasome is composed of constitutive and immuno subunits and exhibits all three catalytic activities. Moreover, the complex displays distinct post‐translational modifications, indicating specialization for extracellular roles, as demonstrated by its enhanced caspase‐like activity. We also found that physiological stress significantly upregulates serum 20S proteasome levels, paralleling human data. This research highlights the specialized characteristics of circulating proteasomes, offering new insights into protein turnover in the blood with significant implications for understanding proteostasis beyond the intracellular environment.
Temperature‐Dependent Kinetic Study of the Gas Phase Ozonolysis of Linalool, Nerol, and Citronellol
Authors: Alossaily Mohamad Ghaleb , Shamas Mirna , Chakir Abdelkhaleq , Roth Estelle 
Published: January 2025

ABSTRACTThe gas phase reactions of the ozonolysis of three monoterpene alcohols: linalool, nerol, and citronellol, were investigated using a rigid atmospheric simulation chamber coupled to a proton transfer reaction‐mass spectrometer (PTR‐ToF‐MS) to monitor the concentrations of the investigated compounds. Reaction rate constants were determined over the temperature range of 298–353 K at atmospheric pressure. Reaction rate constants (×1016 cm3 molecule−1 s−1) at 298 K are 3.12 ± 0.30 for linalool, 8.89 ± 0.90 for nerol, and 2.11 ± 0.10 for citronellol. The following Arrhenius expressions were established (cm3 molecule−1 s−1):
The obtained rate constants are presented and compared to those found in the literature at room temperature, as well as to homologous alkenes. Based on the obtained rate constants, the tropospheric lifetimes of the studied compounds due to their elimination by ozonolysis were estimated to be about 1 hour.
Hearing Loss and Discrimination: Evidence of Intersectionality in the All of Us Research Program
Authors: Denham Michael W. , Tucker Lauren H. , Golub Justin S. 
Published: January 2025

ObjectivesHearing loss (HL) has significant implications on social functioning. Here, we study the relationship between HL, race, and these combined categories as risk factors for discrimination in the large national All of Us cohort.MethodsThe National Institutes of Health All of Us dataset was analyzed after including individuals who completed the Everyday Discrimination Survey between November 2021 and January 2022. HL and potential medical confounders were defined per ICD‐10 codes or demographics. Multivariable linear regressions analyzing the relationship between HL and discrimination were adjusted for potential confounders, including age, gender, race, ethnicity, other demographic factors, and relevant medical conditions, such as depression and dementia. Additional regressions were conducted to evaluate how combined HL and race categories associated with discrimination risk.ResultsTotally 8,722 individuals ≥18 years old had complete data. The mean age was 65 years (SD = 13.0 years), and 41% were women. Individuals with HL, compared with those without, were more likely to report discrimination in six out of nine questions on the Everyday Discrimination Survey (p < 0.05, with effect sizes ranging from −0.05 to −0.16 on a 6‐point scale from 0 = “Almost everyday” to 5 = “Never”). Notably, for four out of those six questions, combined Black race and HL was associated with a risk of discrimination independent from the risk conveyed by race and/or HL individually.ConclusionsThis study offers evidence of HL as a risk factor for self‐reported discrimination. Further, this study provides support for an intersectional understanding between discrimination, race, and HL.Level of EvidenceIII, Laryngoscope, 2024 Laryngoscope, 2025
An interracial Mendelian analysis revealed a link between lipid‐lowering drugs and renal failure
Authors: Zhang Naidan , Ji Chaixia , Xie Baibing , Liu Yaoyang , Yuan Chengliang 
Published: January 2025

AbstractLipid‐lowering drugs have been used in clinics widely. It is unclear whether the drugs have an effect on renal failure. We chose high‐density lipoprotein cholesterol (ieu‐b‐109), low‐density lipoprotein cholesterol (ieu‐a‐300), triglyceride (ieu‐b‐111), and total cholesterol (ebi‐a‐GCST90038690) as exposures. SNPs near drug genes served as instrumental variables. Acute renal failure (ARF) and chronic renal failure (CRF) in Europeans from the GWAS catalog were selected as outcomes. Datasets on renal failure in East Asians and South Asians were used for validation. Inverse variance weighted (IVW) was the primary method for drug‐targeted Mendelian randomization. In the Europeans, people who used PPARG reduced ARF risk by 69.3% (OR: 0.307, 95% CI: 0.171–0.553, p = 0.015). NPC1L1 inhibitors increased ARF risk by 2.684 times (OR: 2.684, 95% CI: 2.027–3.341, p = 0.003). APOE increased ARF risk by 1.987 times (OR: 1.987, 95% CI: 1.062–3.716, p = 0.032) but decreased CRF risk by 49.7% (OR: 0.503, 95% CI: 0.283–0.894, p = 0.019). TNFSF12 increased CRF risk by 3.866 times (OR: 3.866, 95% CI: 1.174–12.729, p = 0.026). In the East Asians, PPARG reduced CRF risk by 85.8% (OR: 0.142, 95% CI: 0.054–0.371, p < 0.001). And in the South Asians, APOE decreased ARF risk by 99.8% (OR: 0.002, 95% CI: 2.12e‐05‐0.179, p = 0.007). We revealed that PPARG could reduce the risk of renal failure in Europeans and Asians. APOE could cause ARF in the Europeans, but it was protective in the South Asians. Clinicians need to consider the characteristics of the local population before administering drugs to patients of different ethnicities.