bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring gene signatures and regulatory networks in a rat model of sciatica: implications and validation in neuropathic pain
Authors: Xu Mu , Wang Zhijian , Xu Gang , Zhu Mengye , Zhang Daying , Yan Yi 
Published: February 2024

BackgroundSciatica (neuropathic pain [NP]) is a common disease characterized by pain from radiation along the sciatic nerve. The aim of this study was to study the genes associated with chronic systolic injury of sciatic nerve (SCN-CCI) in rats by RNA-Seq technique, and to explore their potential as therapeutic targets.MethodsSciatic nerve rat model was obtained by ligation of sciatic nerve and divided into two groups: SCN-CCI group and Sham group. Behavioral assessments were performed to evaluate pain sensitivity, following which their spinal cord dorsal horn were resected and RNA sequencing was conducted to identify differentially expressed genes (DEGs). Bioinformatics and functional enrichment analysis was performed to identify promising DEGs and their related biological processes and pathways associated with SCN-CCI. PPI network analysis and hub gene identification were conducted. QRT-PCR, western blot, ELISA, and immunofluorescence staining were performed on rat models to validate the expression of these hub genes and investigate related proteins and inflammatory markers.ResultsThe SCN-CCI rat model was successfully obtained, exhibiting increased pain sensitivity compared to the Sham group, as indicated by decreased mechanical allodynia thresholds, thermal latencies, and increased paw withdrawals. RNA-Seq analysis identified 117 DEGs in the SCN-CCI rat model, involved in various biological processes and pathways related to sciatica. PPI network analysis revealed hub genes, including Ly6g6e, which exhibited significant differential expression. QRT-PCR and Western blot analysis confirmed the expression patterns of these hub genes. Pain behavior assessment demonstrated reduced pain thresholds and increased paw flinching responses in the SCN-CCI group. Furthermore, the SCN-CCI group showed upregulated expression of Ly6g6e, increased protein levels of Ly6g6e, CGRP, and NGF, as well as elevated levels of IL-1β, MCP-1, and IL-6, and microglial cell activation in the spinal dorsal horn. ELISA results confirmed the increased levels of IL-1β, MCP-1, and IL-6 in the spinal dorsal horn.ConclusionThese comprehensive findings provide valuable insights into the SCN-CCI rat model, DEGs associated with sciatica, hub genes (Ly6g6e as promising targets), pain behavior changes and molecular alterations.
High-risk prostate cancer treated with a stereotactic body radiation therapy boost following pelvic nodal irradiation
Authors: Lischalk Jonathan W. , Akerman Meredith , Repka Michael C. , Sanchez Astrid , Mendez Christopher , Santos Vianca F. , Carpenter Todd , Wise David , Corcoran Anthony , Lepor Herbert , Katz Aaron , Haas Jonathan A. 
Published: February 2024

PurposeModern literature has demonstrated improvements in long-term biochemical outcomes with the use of prophylactic pelvic nodal irradiation followed by a brachytherapy boost in the management of high-risk prostate cancer. However, this comes at the cost of increased treatment-related toxicity. In this study, we explore the outcomes of the largest cohort to date, which uses a stereotactic body radiation therapy (SBRT) boost following pelvic nodal radiation for exclusively high-risk prostate cancer.Methods and materialsA large institutional database was interrogated to identify all patients with high-risk clinical node-negative prostate cancer treated with conventionally fractionated radiotherapy to the pelvis followed by a robotic SBRT boost to the prostate and seminal vesicles. The boost was uniformly delivered over three fractions. Toxicity was measured using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Oncologic outcomes were assessed using the Kaplan–Meier method. Cox proportional hazard models were created to evaluate associations between pretreatment characteristics and clinical outcomes.ResultsA total of 440 patients with a median age of 71 years were treated, the majority of whom were diagnosed with a grade group 4 or 5 disease. Pelvic nodal irradiation was delivered at a total dose of 4,500 cGy in 25 fractions, followed by a three-fraction SBRT boost. With an early median follow-up of 2.5 years, the crude incidence of grade 2+ genitourinary (GU) and gastrointestinal (GI) toxicity was 13% and 11%, respectively. Multivariate analysis revealed grade 2+ GU toxicity was associated with older age and a higher American Joint Committee on Cancer (AJCC) stage. Multivariate analysis revealed overall survival was associated with patient age and posttreatment prostate-specific antigen (PSA) nadir.ConclusionUtilization of an SBRT boost following pelvic nodal irradiation in the treatment of high-risk prostate cancer is oncologically effective with early follow-up and yields minimal high-grade toxicity. We demonstrate a 5-year freedom from biochemical recurrence (FFBCR) of over 83% with correspondingly limited grade 3+ GU and GI toxicity measured at 3.6% and 1.6%, respectively. Long-term follow-up is required to evaluate oncologic outcomes and late toxicity.
Clinical characteristics and risk factors analysis of 505 cases of infusion reactions in a tertiary hospital
Authors: Yin Weiwei , Wen Bingqin , Wang Guoan , Wang Zhipeng , Kong Xuetao , Wu Yaozhou , Meng Xiao , Ou Xinyi , Wei Li , Yu Pengjiu 
Published: February 2024

Background: The clinical characteristics and risk factors of infusion reactions (IRs) are inadequately described in clinical practice due to underreported cases. In the present study, we reported the current status of IRs based on an in-hospital pharmacovigilance database of a tertiary care hospital.Methods: Our study conducted a retrospective analysis of drug-induced IRs recorded at an in-hospital pharmacovigilance center between January 2015 to December 2019. The descriptive statistical analysis encompassed main causative agents, clinical manifestations, organ/system involvement and outcome. The severity of IRs was assessed with reference to the CTCAE version 5.0 criteria and we investigated risk factors associated with severe IRs.Results: During the study period, a total of 505 cases of inpatient drug-induced IRs were detected, of which 79.2% (400 cases) were classified as general IRs and 20.8% (105 cases) were categorized as severe IRs. The primary drugs responsible for these reactions were antibiotics (23%, 116 cases), with piperacillin sodium—sulbactam sodium being the most prevalent, followed by antineoplastic agents (18.4%, 93 cases) and traditional Chinese medicine injections (TCMIs) (12.9%, 65 cases). The administration of cefoperazone - sulbactam, mannatide, Shenqi Fuzheng, elemene, and diterpene ginkgolides meglumine resulted in a higher incidence of critical IRs. Among all cases of IRs, 43.2%, 41.2%, and 23.4% showed signs and symptoms of circulation, skin mucosa, and respiratory organs/systems, respectively. 9.1% of cases experienced systemic damage, while 7.1% and 5.9% of cases reported neurological and gastrointestinal related adverse reactions, respectively. The multivariate analysis revealed that alcohol consumption (OR = 2.389%, 95% CI 1.141–5.002, p = 0.021), age over 65 (OR = 1.814%, 95% CI 1.052–3.127, p = 0.032) and the utilization of contrast media (OR = 4.072%, 95% CI 1.903–8.713, p &lt; 0.001) were identified as risk factors for the development of severe IRs.Conclusion: Understanding the clinical characteristics of IRs helps to implement effective pharmaceutical monitoring and appropriate preventive measures for susceptible populations with risk factors.
A lighthearted approach to mindfulness: development and evaluation of a humor-enriched mindfulness-based program in a randomized trial
Authors: Kastner Christian T. 
Published: February 2024

ObjectivesRecently, research on mindfulness and humor has begun to spark interest, both being essential contributors to well-being. This article proposes that forms of humor that share intention and attitudinal foundations with mindfulness, constitute the foundation of a mindful-humorous perspective and mindful humor. Once intention and attitude are in alignment, shared mechanisms underlying a mindful-humorous perspective may lead to synergetic effects (e.g., reinforcing a shift in perspective and attitudinal foundations) as summarized in the proposed mindful humor filter model (MHFM). Based on this theoretical framework, the humor-enriched mindfulness-based program (HEMBP) was developed and evaluated for validity and efficacy in a randomized controlled trial as a first step to test the newly introduced model.MethodsA total of 60 participants were randomly allocated to either the HEMBP or a wait-list control group. Participants' mindfulness, comic styles (e.g., benevolent humor, sarcasm, and cynicism), psychological well-being, life satisfaction, stress, and gelotophobia (fear of being laughed at) were assessed 1 week before and after training, and at a 1-month follow-up. Linear mixed-effects models were fitted to model changes in outcome variables over time.ResultsThe HEMBP was effective in increasing mindfulness, benevolent humor, and psychological well-being, and in reducing sarcasm, cynicism, stress, and gelotophobia, compared to the control group.ConclusionResults support the validity and efficacy of the HEMBP as a promising approach for improving well-being and reducing stress. The HEMBP broadens the scope of existing mindfulness-based programs by cultivating a mindful-humorous outlook on life, facilitating mindfulness practice and insights, and fostering positive emotions and relationships with others through mindful humor. Results are also suggestive of the validity of the mindful humor filter model.
The hemophilia quality of life scale: a systematic review
Authors: Wang Xin , Li Zhixiao , Li Lele 
Published: February 2024

PurposeQuality of life refers to the degree of well-being a person feels. The development of a hemophilia-targeting quality of life scale is important for hemophiliacs and their treating physicians.MethodsTextual analysis. First, a review of studies on quality of life, hemophilia and related quality of life scales was conducted; Subsequently, two rounds of systematic searches of the Springer database were conducted to filter the literature on universal quality of life scale studies and hemophilia-targeting quality of life scale studies by title and abstract, and then textual analysis was performed.ResultsThe former included 77,456 articles, 26,117 chapters and 7,086 related bibliographies, while the latter initially retrieved 211 entries articles, 118 chapters and 43 related bibliographies. Through filtering, the former contains 22 documents, yielding 1,431 valid word stems, and the latter contains 9 documents, yielding 1,541 valid word stems.ConclusionWhile universal quality of life scales mostly fit into the broad framework of WHOQOL- BREF, the development of hemophilia-targeting quality of life scales inclines towards pains that patients suffer and technology advances in pharmaceutical. The current hemophilia QOL scales are mainly based on the HR-QoL, others mainly based on the HR-QoL as the master version. At the same time, the popularization of existing hemophilia quality of life scales in developing countries like China is not high, and the development of hemophilia quality of life scales is insufficient.
Effects of medical interventions on health-related quality of life in chronic disease – systematic review and meta-analysis of the 19 most common diagnoses
Authors: Riecke Franziska , Bauer Leandra , Polzer Hans , Baumbach Sebastian Felix , Neuerburg Carl , Böcker Wolfgang , Grill Eva , Saller Maximilian Michael 
Published: February 2024

IntroductionThe demographic shift leads to a tremendous increase in age-related diseases, which are often chronic. Therefore, a focus of chronic disease management should be set on the maintenance or even improvement of the patients’ quality of life (QoL). One indicator to objectively measure QoL is the EQ-5D questionnaire, which was validated in a disease- and world region-specific manner. The aim of this study was to conduct a systematic literature review and meta-analysis on the QoL across the most frequent chronic diseases that utilized the EQ-5D and performed a disease-specific meta-analysis for treatment-dependent QoL improvement.Materials and methodsThe most common chronic disease in Germany were identified by their ICD-10 codes, followed by a systematic literature review of these ICD-10 codes and the EQ-5D index values. Finally, out of 10,016 independently -screened studies by two persons, 538 studies were included in the systematic review and 216 studies in the meta-analysis, respectively.ResultsWe found significant medium to large effect sizes of treatment effects, i.e., effect size &gt;0.5, in musculoskeletal conditions with the exception of fractures, for chronic depression and for stroke. The effect size did not differ significantly from zero for breast and lung cancer and were significantly negative for fractures.ConclusionOur analysis showed a large variation between baseline and post-treatment scores on the EQ-5D health index, depending on the health condition. We found large gains in health-related quality of life mainly for interventions for musculoskeletal disease.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020150936, PROSPERO identifier CRD42020150936.
Differences in surgical outcomes between cervical goiter and retrosternal goiter: an international, multicentric evaluation
Authors: Cappellacci Federico , Canu Gian Luigi , Rossi Leonardo , De Palma Andrea , Mavromati Maria , Kuczma Paulina , Di Filippo Giacomo , Morelli Eleonora , Demarchi Marco Stefano , Brazzarola Paolo , Materazzi Gabriele , Calò Pietro Giorgio , Medas Fabio ,   our Mediastinal Goiter Study Collaborative Group
Published: February 2024

IntroductionGoiter is a common problem in clinical practice, representing a large part of clinical evaluations for thyroid disease. It tends to grow slowly and progressively over several years, eventually occupying the thoracic inlet with its lower portion, defining the situation known as retrosternal goiter. Total thyroidectomy is a standardized procedure that represents the treatment of choice for all retrosternal goiters, but when is performed for such disease, a higher risk of postoperative morbidity is variously reported in the literature. The aims of our study were to compare the perioperative and postoperative outcomes in patients with cervical goiters and retrosternal goiters undergoing total thyroidectomy.MethodsIn our retrospective, multicentric evaluation we included 4,467 patients, divided into two groups based on the presence of retrosternal goiter (group A) or the presence of a classical cervical goiter (group B).ResultsWe found statistically significant differences in terms of transient hypoparathyroidism (19.9% in group A vs. 9.4% in group B, p &lt; 0.001) and permanent hypoparathyroidism (3.3% in group A vs. 1.6% in group B, p = 0.035). We found no differences in terms of transient RNLI between group A and group B, while the occurrence of permanent RLNI was higher in group A compared to group B (1.4% in group A vs. 0.4% in group B, p = 0.037). Moreover, no differences in terms of unilateral RLNI were found, while bilateral RLNI rate was higher in group A compared to group B (1.1% in group A vs. 0.1% in group B, p = 0.015).DiscussionWound infection rate was higher in group A compared to group B (1.4% in group A vs. 0.2% in group B, p = 0.006). Based on our data, thyroid surgery for retrosternal goiter represents a challenging procedure even for highly experienced surgeons, with an increased rate of some classical thyroid surgery complications. Referral of these patients to a high-volume center is mandatory. Also, intraoperative nerve monitoring (IONM) usage in these patients is advisable.
Wafer-scale characterization for two-dimensional material layers
Authors: Moussa A. , Bogdanowicz J. , Groven B. , Morin P. , Beggiato M. , Saib M. , Santoro G. , Abramovitz Y. , Houchens K. , Ben Nissim S. , Meir N. , Hung J. , Urbanowicz A. , Koret R. , Turovets I. , Lee B. , Lee W.T. , Lorusso G. F. , Charley A.-L. 
Published: February 2024

AbstractLogic devices based on two-dimensional (2D) channel materials require highly crystalline monolayers. Despite various laboratory-scale metrology techniques being intensively used to characterize 2D materials on small coupons, the development of in-line and routine characterization of 2D material monolayers grown on 300 mm wafers remains in its early stages. In this work, we evaluate and combine different in-line metrologies to characterize the thickness and morphology of tungsten disulfide (WS2) monolayers at the 300 mm wafer level. By combining complementary metrology techniques, we reveal the morphology of WS2, the WS2layer thickness and within-wafer uniformity for different WS2deposition conditions across 300 mm wafers.
One-dimensional assemblies of magnetic iron-oxide nanoparticles
Authors: Shiojima Takumi , Sakurai Junpei , Hata Seiichi , Oka Chiemi 
Published: February 2024

Abstract
Although high-aspect-ratio iron-oxide nanoparticles (IONPs) are known to have higher heating efficiency than spherical and cubic IONPs and focused in cancer treatment areas, their synthesis methods require high temperatures, vacuum, reduction conditions, and substantial time. In this study, we proposed and established a facile manufacturing method for one-dimensional assemblies of IONPs, expected to increase heating efficiency similar to high-aspect-ratio IONPs. We investigated how the fabrication conditions affect the length of the assemblies and found that the average length of the one-dimensional assemblies increased with the extension of magnetic-field-application time. This result demonstrates that the length could be controlled by adjusting the duration of the magnetic field application.
Demonstration of recycling process for GaN substrates using laser slicing technique towards cost reduction of GaN vertical power MOSFETs
Authors: Ishida Takashi , Ushijima Takashi , Nakabayashi Shosuke , Kato Kozo , Koyama Takayuki , Nagasato Yoshitaka , Ohara Junji , Hoshi Shinichi , Nagaya Masatake , Hara Kazukuni , Kanemura Takashi , Taki Masato , Yui Toshiki , Hara Keisuke , Kawaguchi Daisuke , Kuno Koji , Osajima Tetsuya , Kojima Jun , Uesugi Tsutomu , Tanaka Atsushi , Sasaoka Chiaki , Onda Shoichi , Suda Jun 
Published: February 2024

Abstract
To address the issue of the high cost of GaN substrates, a recycling process for GaN substrates using a laser slicing technique was investigated. The channel properties of lateral MOSFETs and the reverse characteristics of vertical PN diodes, which represent the main components of vertical power devices, exhibited no degradation either before and after laser slicing or due to the overall GaN substrate recycling process. This result indicates that the proposed recycling process is an effective method for reducing the cost of GaN substrates and has the potential to encourage the popularization of GaN vertical power devices.
Riwayat Menstruasi, Kehamilan yang Tidak Direncanakan dan Paparan Asap Rokok pada Anemia Ibu Hamil Suku Bajo
Authors: Banudi La , Nurfitrah Endang , Arsulfa Arsulfa , Reyana Hesti 
Published: February 2024

Latar Belakang: Anemia pada ibu hamil adalah keadaan dimana kadar hemoglobin (Hb) pada wanita hamil Trimester I dan III adalah < 11 gr/dl sedangkan pada Trimester II kadar Hb adalah <10,5 gr/dl. Anemia pada kehamilan disebabkan karena kebutuhan zat besi selama hamil cenderung mengalami peningkatan. Tujuan : Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan riwayat menstruasi berlebih, kehamilan yang tidak direncanakan dan paparan asap rokok terhadap kejadian anemia pada ibu hamul. Metode: Studi Cross-sectional. Populasi pada penelitian ini adalah seluruh ibu hamil suku bajo yang berada di wilayah kerja Puskespas Soropia yang berjumlah 53 orang. Instrument penelitian yang digunakan adalah lembar koesioner sedangkan analisis data yang digunakan adalah uji Chi Square. Hasil: hasil analisis bivariat menunjukkan bahwa terdapat hubungan antara riwayat menstruasi berlebih dengan kejadian anemia pada ibu hamil (p = 0,009), terdapat hubungan antara paparan asap rokok terhadap kejadian anemia pada ibu hamil (p = 0,020). Tidak terdapat hubungan antara kehamilan yang tidak direncanakan dengan kejadian anemia pada ibu hamil (p = 0,901). Simpulan: hasil penelitian ini menunjukkan terdapat hubungan antara riwayat menstruasi berlebih dan paparan asap rokok terhadap kejadian anemia pada ibu hamil dan tidak terdapat hubungan antara riwayat menstruasi berlebih terhadap kejadian anemia pada ibu hamil.
Kata kunci : Riwayat menstruasi berlebih, Kehamilan yang tidak direncanakan, Paparan asap rokok, Anemia ibu hamil.
Efek Pemberian Formula Tepung Mocaf, Kacang Merah Dan Ikan Bandeng Untuk Balita Gizi Kurang Di Puskesmas Sabokingking
Authors: Delmi Zahroh Istantini , Podojoyo Podojoyo , Muzakar Muzakar , Nazarena Yunita , Sriwiyanti Sriwiyanti 
Published: February 2024

Background : One of the nutrition major problems in Indonesia is malnutrition. Age <5 years is a very important period in the process of child development. Therefore, during this period, child nutritional intake and health care must be considered . Purpose : To see the effect of giving biscuits formula of mocaf, red bean, and milkfish flour on the body weight of undernourished children at the Sabokingking Health Center. Methods : This research was conducted in 2 stages. In the first stage, it uses an experimental research type with a completely randomized non-factorial design. Then the second stage uses a quasi-experimental type of research with pre-test and post-test designs with two groups. This research was conducted in January-April 2022 at the Sabokingking Health Center with a total sample of 30 children under five in each group, which was determined by a non-random method based on inclusion criteria. Results : The results of the Independent T-Test showed that there was no significant difference in the average weight gain in the treatment and comparison groups with a p-value of 0.15 (> 0.05). Conclusion : There is no effect of giving the formulated cookies to the body weight of children under 5.
Objective and Automated Quantification of Instrument Handling for Open Surgical Suturing Skill Assessment: A Simulation-Based Study
Authors: Singh Simar 
Published: February 2024

Goal: Vascular surgical procedures are challenging and require proficient suturing skills. To develop these skills, medical training simulators with objective feedback for formative assessment are gaining popularity. As hardware advancements offer more complex, unique sensors, determining effective task performance measures becomes imperative for efficient suturing training. Methods: 97 subjects of varying clinical expertise completed four trials on a suturing skills measurement and feedback platform (SutureCoach). Instrument handling metrics were calculated from electromagnetic motion trackers affixed to the needle driver. Results: The results of the study showed that all metrics significantly differentiated between novices (no medical experience) from both experts (attending surgeons/fellows) and intermediates (residents). Rotational motion metrics were more consistent in differentiating experts and intermediates over traditionally used tooltip motion metrics. Conclusions: Our work emphasizes the importance of tool motion metrics for open suturing skills assessment and establishes groundwork to explore rotational motion for quantifying a critical facet of surgical performance.
Impact Statement–This study aims to determine the effectiveness of metrics derived from needle driver rotational and tooltip motion tracking to determine differences in clinical expertise in open needle driving.