bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREVALENCE OF MIGRAINE, PEPTIC ULCER, CORONARY HEART DISEASE AND HYPERTENSION IN CLUSTER HEADACHE
Authors: Kudrow Lee 
Published: June 2005

SYNOPSIS The prevalence of migraine, peptic ulcer disease, coronary heart disease and hypertension was compared in 140 patients with cluster headache and in two control groups.Cluster headache women have a significantly higher incidence of migraine than controls. Migraine was more common among cluster headache males, but the difference was not statistically significant.Peptic ulcer in males with cluster headache was significantly more prevalent than in controls, but this difference was not significant statistically for women.Coronary heart disease was more common in cluster males but this was not statistically significant. None of the cluster women had evidence of coronary heart disease.The incidence of hypertension in cluster patients was less than in controls though the difference was not statistically significant.
RELATIVE POTENCY SCALE FOR ANALGESIC DRUGS: USE OF PSYCHOPHYSICAL PROCEDURES WITH CLINICAL JUDGMENTS
Authors: Coyne Lolafaye , Sargent Joseph , Segerson Jack , Obourn Robert 
Published: June 2005

SYNOPSIS A clinically useful scale to measure differences in effectiveness between various commonly used analgesics in the treatment of migraine headache is described. Except for oral Demerol, which is not often used for the treatment of migraine, other analgesics can be compared numerically in their potency with each other.
HUMAN PLASMA LEVELS OF SOME ANTI‐MIGRAINE DRUGS
Authors: Meier J. , Schreier E. 
Published: June 2005

SYNOPSISFour compounds of therapeutic value in the treatment of migraine attacks or for the prophylaxis of migraine and other vascular headaches, ergotamine, dihydroergotamine, methysergide and pizotifen are given in low dosages and achieve low in vivo concentration. Human plasma levels were determined by measurement of radioactivity after oral administration of the corresponding radioactively labeled compounds. The labeling of the four compounds with tritium or carbon‐14 is briefly described. The procedure to measure radioactivity of the blood samples is given. The values from single dose experiments in healthy volunteers were analysed based on a compartment model which allows for the formation of metabolites. The calculated pharmacokinetic constants have been used for simulations and predictions of plasma levels after different therapeutic dosages.
RAT FUNDUS STRIP AND UTERUS CONTRACTING ACTIVITY OF SERA: RELATIONSHIP TO MIGRAINE ATTACKS
Authors: Nattero G. , Lisino F. , Brandi G. , Bisbocci D. , Bernardi V. , Bottini A. , Griffa G. , Ramella M.R. , Scalabrino M. 
Published: June 2005

SYNOPSISSera from ten migraineurs were examined in headache free periods and during spontaneous attacks for their capacity to contract the rat fundus and uterus in vitro. Sera from two controls were similarly tested.A “pool” of vasoactive substances which contracted the rat uterus in vitro was always present in the pre attack stage, during the attack and immediately after the migrainous attack.The contracting activity of sera from migraineurs was also confirmed on the rat fundus strip in vitro. These sera contained serotonin or a serotonin‐like substance. The level of this contracting substance in the sera from migraineurs was lowest during migraine attacks.Control sera also induced rat uterus contractions in vitro. However, this contracting activity was not always present, whereas sera from migraineurs always contracted rat uterus preparations during migraine headache.
BROMOCRIPTINE IN MIGRAINE
Authors: Hockaday Judith M. , Peet Katherine M.S. , Hockaday T.D.R. 
Published: June 2005

SYNOPSISSeven women with early menstrual or premenstrual migraine were given CB154 (Bromocriptine) over 15 menstrual cycles. In 12 menstrual cycles only one migraine attack occurred. Bromocriptine in a dose of 1 mg tid. at 4 day intervals was effective in relieving menstrual migraine and major symptoms of the premenstrual syndrome in these patients. However, the observations are preliminary but they suggest that a controlled trial of the drug in selected patients is justified.
BIOFEEDBACK THERAPY FOR MIGRAINE
Authors: Medina Jose L. , Diamond Seymour , Franklin Mary A. 
Published: June 2005

SYNOPSISObjective evaluation of biofeedback for vascular headache has not been carried out. We report on a retrospective study of twenty‐seven patients with migraine or mixed migraine and muscle contraction headache. They were followed for a mean of 10.9 months before training in skin‐temperature and electromyogram biofeedback. After training, they were under our care for an average of 14.2 months. The severity and frequency of headaches and the amount of medication token during the post‐biofeedback period was compared with the last two months prior to biofeedback. A significant improvement was obtained in thirteen patients. Biofeedback is important in the treatment of migraine.
BIOCHEMICAL COMPARISON OF MIGRAINE AND STROKE
Authors: Welch K.M.A. , Chabi Eva , Nell Janet H. , Bartosh K. , Chee A.N.C. , Mathew N.T. , Achar V.S. 
Published: June 2005

SYNOPSISGamma‐aminobutyric acid (GABA) and 3′, 5′‐cyclic adenosine monophosphate (cyclic AMP) were measured in cerebrospinal fluid (CSF) of patients with stroke and vascular headache of migraine type. GABA was elevated in CSF of patients with recent onset of thromboembolic occlusive cerebrovascular disease (CVD) and within 48 hours of an attack of vertebrobasilar ischemia (VBI). Similarly, GABA was elevated in CSF of all patients studied during a migraine attack but not in asymptomatic migraine patients or patients with muscle contraction (tension) headache. CSF cyclic AMP was also elevated in patients with recent onset of thromboembolic occlusive CVD and in patients studied during or within 48 hours of a migraine attack.Since biochemical abnormalities reported herein were common to occlusive CVD and migraine headache, it seems probable that they are due to ischemia associated with both conditions and possibly related to the resultant disorder of cerebral energy metabolism.
RENIN RESPONSE DURING HEMODIALYSIS HEADACHE
Authors: Bana Dhirendra S. , Graham John R. 
Published: June 2005

SYNOPSISOf thirteen patients on chronic hemodialysis, nine had headache during dialysis and four did not. Plasma renin levels were low in patients with headaches and even lower when the sample was obtained during headache. There was one exception to this general trend (described in the text). Patients with no history of headache at all had normal or high plasma renin values.
EFFECTS OF BIOFEEDBACK UPON SUPPRESSION OF MIGRAINE SYMPTOMS AND PLASMA DOPAMINE‐β‐HYDROXYLASE ACTIVITY
Authors: Kentsmith D. , Strider F. , Copenhaver J. , Jacques D. 
Published: June 2005

SYNOPSISThis study demonstrates symptomatic improvement of migraine achieved by combined methods of concentrative meditation, biofeedback, and relaxation training. As a correlate of this treatment, the plasma levels of dopamine‐β‐hydroxylase activity decreased. An identical treatment regime in a control subject produced only transient minimal decreases in blood levels of DBH activity.
CONTROL OF MIGRAINE HEADACHE BY BEHAVIORAL SELF‐MANAGEMENT: A CONTROLLED CASE STUDY
Authors: Mitchell Kenneth R. , White Ronald G. 
Published: June 2005

SYNOPSISThe reactive effects of self‐recording and self‐monitoring of behavior on the frequency of migraine headaches were examined over a period of 75 weeks and were compared with two stages of semiautomated training in behavioral self‐management. Stage One included training in and application of problem analysis, goal setting, self‐recording, self‐monitoring, environmental planning and manipulation, muscle, mental and differential relaxation, self‐desensitization and self‐evaluation of change. Stage Two continued with training in 13 additional self‐change skills. The results suggest that self‐recording and self‐monitoring alone were not effective in reducing the frequency of migraine headaches. The training for Stage One of behavioral self‐management resulted in a 52% reduction in headaches, while for Stages One and Two, 72% reduction was noted. Over an eight month follow‐up period the incidence of migraine was reduced to zero.
FENFLURAMINE HEADACHE
Authors: Sicuteri F. , Del Bene E. , Anselmi B. 
Published: June 2005

SYNOPSISDrug acting on brain monoamines (5HT) were tested on EH sufferers. Fenfluramine, an anorectic agent, acts principally on brain 5HT. This drug, when given to EH sufferers, precipitates and aggravates pain. The headache provoked by fenfluramine is tachyphylactic, suggesting involvement of central transmitters. Therapeutic doses of fenfluramine do not affect blood vessel diameter. This further supports a biochemical mechanism for fenfluramine headache. A reversible systemic pain syndrome has been observed in two EH sufferers, treated chronically with fenfluramine. This syndrome appears indistinguishable from that previously observed in EH sufferers, given parachlorophenylalanine, an inhibitor of 5HT synthesis. The effect of fenfluramine supports the hypothesis that established and other experimental anti‐migraine drugs act centrally by correcting abnormalities in the 5HT nociceptive system.
BIOFEEDBACK‐PSYCHOTHERAPY FOR THE TREATMENT OF HEADACHES: A 5‐YEAR FOLLOW‐UP
Authors: Adler Charles Spencer , Adler Sheila Morrissey 
Published: June 2005

SYNOPSISA psychodynamic approach to the use of biofeedback with chronically disabled headache patients was effective in 86% causing a 75‐100% reduction of headache frequency which has persisted over a 5‐year period.
VASCULAR REACTIVITY OF MIGRAINEURS AND NON‐MIGRAINEURS: A COMPARISON OF RESPONSES TO SELF‐CONTROL PROCEDURES
Authors: Price Kenneth P. , Tursky Bernard 
Published: June 2005

SYNOPSISThe responses to training of an autonomic relaxation response (peripheral vasodilatation) were studied. Forty migraine sufferers and forty controls were assigned to one of four treatments: (1) binary and analog feedback, (2) yoked (false) feedback, (3) relaxation‐tape induction, and (4) neutral‐tape control. The integral change of digital and extracranial blood volume was measured during one session. Responses of migraine sufferers were markedly different from normal subjects. No incremental utility of biofeedback over a simple relaxation procedure in the production of peripheral vasodilatation was found. High positive correlations were found between digital and extracranial blood volume changes.
“MIGRAINOUS” NEUROLOGIC DYSFUNCTION IN PATIENTS WITH PROSTHETIC CARDIAC VALVES
Authors: Caplan Louis R. , Weiner Howard , Weintraub Ronald M. , Austen W. Gerald 
Published: June 2005

SYNOPSISTwo patients developed frequent, multifocal, transient episodes of central nervous system dysfunction, frequently accompanied by headache, 14 and 42 months after insertion of prosthetic cardiac valves. The disorder satisfied the criteria for the diagnosis of classic migraine; it was self‐limited in one patient and remitted after diphenylhydantoin in the other. Three other patients with “migrainous accompaniments” after cardiac surgery have been seen. “Symptomatic migraine” may occur in patients with prosthetic cardiac valves. The mechanism and etiology of this disorder is obscure.
ICE CREAM HEADACHE AND ORTHOSTATIC SYMPTOMS IN PATIENTS WITH MIGRAINE
Authors: Raskin Neil H. , Knittle Steve C. 
Published: June 2005

SYNOPSISMigraine is arbitrarily defined; biological markers for the condition are needed. Two stereotyped phenomena which may be manifestations of central vasomotor instability have been studied in migraineurs and in control subjects. These phenomena are (1) “ice cream headache”, the brief frontal pain that results from cold food contacting the roof of the oropharynx and (2) the presence of vertigo, visual obscurations, and/or scintillating scotomata following rapid postural shifts of the head.Hospitalized (non‐neurologic) patients (60 women, 48 men) were interviewed regarding the presence, quality, and intensity of the two phenomena. A history of headache was then elicited in some detail. The headache histories were assessed by the usual arbitrary criteria for migraine; this was done by an independent observer without knowledge of the presence of ice cream headache or postural symptoms. In the non‐headache, control population (49), 31% had experienced mild ice cream headache; in the migraine group (59), 93% had experienced ice cream headache (p<.001), usually (77%) as a moderate to severe discomfort. Half of the migraineurs took precautions when ingesting cold foods. Of the controls, 8% had brief vertigo or lightheadedness with rapid postural shifts; postural symptoms were present in 68% of the migraine group (p>.001), most of whom (75%) reported that scintillating scotomata accompanied vertigo. Both syndromes occurred more regularly and more prominently in the migraine population.
ERGOTAMINE AND METHYSERGIDE AS SEROTONIN PARTIAL AGONISTS IN MIGRAINE
Authors: Fanciullacci M. , Granchi G. , Sicuteri F. 
Published: June 2005

SYNOPSISPotentiation of venospastic action of 5‐HT by methysergide and ergotamine was demonstrated in man by using venomotor receptors as substrate in a venoconstriction test. 5‐HT facilitation was observed only when anti‐migraineous drugs were tested in concentrations similar to those expected after therapeutic administration. When ergotamine and methysergide were used in higher concentrations, the expected antagonism to 5‐HT was clearly demonstrated. It is concluded that methysergide and ergotamine therapy is not antiserotonergic. These drugs act as partial agonists of 5‐HT. Methysergide and ergotamine facilitation of 5‐HT activity may occur at peripheral vasomotor receptors, or centrally in the brain. This latter probably is consistent with the postulated central nature of pain in essential headache.
CEPHALIC VASOMOTOR AND ELECTROMYOGRAPHIC FEEDBACK IN THE TREATMENT OF COMBINED MUSCLE CONTRACTION AND MIGRAINE HEADACHES IN A GERIATRIC CASE
Authors: Feuerstein Michael , Adams Henry E. , Beiman Irving 
Published: June 2005

SYNOPSISThe effects of cephalic vasomotor response (CVMR) feedback and electromyographic (EMG) feedback on control of CVMR, frontalis EMG and temporal artery vasospasms in muscle contraction and migraine headaches were investigated in a 67 year old woman. Systematic reductions in EMG activity were not achieved during EMG feedback. The frequency of temporal artery vasospams declined. No changes in amplitude of blood volume pulse (BVP) were observed during EMG feedback. A decrease in headache activity was associated with EMG feedback which may have been due to the reduction in temporal artery vasospasms. A treatment withdrawal condition was introduced after six EMG feedback sessions during which an increase in headache activity occurred. When CVMR feedback was introduced, the patient achieved significant BVP reductions. This control was related to the largest reduction in headache frequency and duration. Ratings representing subjective perception of the degree of disability because of headache also decreased during EMG feedback, CVMR feedback, and follow‐up. At follow‐up, there was a moderate increase in headache activity which was partially attributed to limited home practice.This case demonstrates the successful use of biofeedback therapy in the treatment of combined vascular and muscle contraction headaches in an elderly patient and suggests that age not be a criterion for eliminating patients from this treatment. In addition, this case further supports the use of cephalic vasomotor feedback as an alternative to temperature training in the treatment of migraine.
PROPRANOLOL FOR MIGRAINE PROPHYLAXIS
Authors: Forssman Bengt , Henriksson K‐G , Johannsson Valur , Lindvall Lars , Lundin Hakan 
Published: June 2005

SYNOPSISThe preventive effect of propranolol on migraine attacks was compared to placebo in a double‐blind cross‐over trial. Thirty‐two patients with serious and prolonged migraine participated in the 12‐week study. The effect of propranolol was significantly better than that of placebo. The number of migraine attacks during the propranolol period was reduced in 22 patients (69%), and in 11 of these (34%) a reduction of more than 50% was seen. The intensity of headache was significantly reduced during the propranolol period. The intake of analgesics and preparations containing ergotamine was significantly reduced during the propranolol period also. No serious side effects were noted.
PERSONALITY, DEPRESSION AND HEADACHE TYPE
Authors: Davis Roger A. , Wetzel Richard D. , Kashiwagi Tetsuo , McClure James N. 
Published: June 2005

SYNOPSISSeventy‐four subjects with a chief complaint of headache of functional origin were tested using the California Psychological Inventory (CPI). No associations were found between individual headache types and personality dimension factors on the CPI. The differences found related to the effect of depression on psychologic test performance. Future studies of personality and headache types need to control for the effect of depression on psychologic testing.
BRIEF REPORT: HEADACHE AND DEPRESSION
Authors: Barolin G. S. 
Published: June 2005

SYNOPSISHeadache is the formost somatic symptom among depressed patients. Patients from an outpatient headache clinic, and from a field study were examined to determine the incidence of depression among headache sufferers. A preponderance of depressive criteria in the headache population was found. Depression was more common in non‐paroxysmal headache sufferers than in migraine patients. Subjects with headache and depression required twice as many leave days per year as those suffering from headache alone. Vertebral‐basilar insufficiency is a frequent cause of “depressive headache”. Anti‐depressant drugs should be used along with headache medication when depression is found. The relationship of depression and headache in the same patient is also discussed.
ABNORMAL CT‐SCANS IN MIGRAINE
Authors: Mathew Ninan T. , Meyer John Stirling , Welch K.M.A. , Neblett Charles R. 
Published: June 2005

SYNOPSISTwenty‐nine patients with migraine were examined by CT‐Scans. Ten of these had abnormalities on the scans which consisted of cerebral parenchymal low densitometric areas, ventricular enlargements and conical atrophy. The cerebral parenchymal low densitometer zones tended to disappear on repeat scanning. Four cases in the series had hemiparetic migraine and all showed abnormalities on CT‐scans. The incidence of complicated migraine was higher in patients who showed abnormalities on the scans than in those with normal scans. It is suggested that the parenchymal low density areas on CT‐scans are the result of cerebral edema, but that repeated insults might lead to permanent changes in brain parenchyma which might be recognizable as cortical atrophy and ventricular enlargement.
MIGRAINE THERAPY WITH HEPARIN: PATHOPHYSIOLOGIC BASIS
Authors: Thonnard‐Neumann Ernst 
Published: June 2005

SYNOPSISDuring headache‐free intervals, migraine patients had in their blood fewer basophilic leukocytes, which also contained less than a normal amount of heparin, and excreted less uroheparin than did controls. During migraine attacks the levels of basophils and of uroheparin rose but did not reach normal values.Sixty patients with severe vascular headaches (fifty‐three migraine and seven cluster) were treated with heparin by intravenous injections or aerosol inhalations. After repeated treatments, basophilic leukocytes and uroheparin levels rose to normal values and remained normal for varying periods, up to 14 months, after the end of therapy.Of the two treatment forms, aerosol therapy was the more effective. It reduced the migraine index of all but two of thirty‐three patients by an average of 86 (75–100) percent, whereas after intravenous therapy eighteen of twenty‐seven patients showed a better than 75 percent improvement.Three to 14 months after the end of therapy, seven patients were entirely free from migraine headaches and three more reported an average improvement of 90 percent.The role of endogenous heparin in migraine and the fate of injected and inhaled heparin are reviewed.
CHANGES IN BLOOD CLOTTING SYSTEMS DURING MIGRAINE ATTACKS
Authors: Kalendovsky Zdenka , Austin James H. 
Published: June 2005

SYNOPSISThe activity of various blood clotting systems was measured during attacks of migraine complicated by prolonged focal cerebral dysfunction and contrasted with those observed when the same and other patients had uncomplicated migraine. Results differed in the two groups.In patients with complicated migraine, plasma coagulability rose during both complicated and uncomplicated attacks. During a complicated migraine attack, platelet aggregability to ADP also rose in all but one patient. Platelet aggregability fell in the same patients when they had uncomplicated migraine. Plasma coagulability consistently increased more when the headache was associated with focal cerebral dysfunction.In patients with uncomplicated migraine, plasma coagulability dropped during the later phase of their attacks. This finding may reflect the release of endogenous heparin from mast cells and basophilic leucocytes. Platelet aggregability to ADP decreased in some but rose in others.The results support the hypothesis that prolonged focal cerebral dysfunction may reflect thromboembolic phenomena. The influence of estrogens and genetic factors on clotting systems is reviewed.
FRONTALIS EMG RESPONSE TO STRESS IN SUBJECTS WITH FREQUENT MUSCLE‐CONTRACTION HEADACHES
Authors: Vaughn Richard , Pall Michael L. , Haynes Stephen N. 
Published: June 2005

SYNOPSISFrontalis electromyogram (EMG) activity was monitored in ten subjects with a high frequency of muscle contraction headaches, and ten subjects with low frequency of muscle contraction headaches at rest, during stressful mental artithmetic and after stress. The frontalis EMG activity of the high‐frequency headache group was significantly greater than that of the low‐frequency headache group in the pre‐stress condition. Significant increases in EMG activity from pre‐stress to stress were found in the low‐frequency headache group but not the high‐frequency headache group. Significant correlations were found between perceived level of relaxation and EMG in the low‐frequency headache group, but not for the high frequency headache group.
A NEW TREATMENT FOR HEADACHE: PATHOPHYSIOLOGIC CONSIDERATIONS
Authors: Lechin Fuad , Van Der Dijs Bertha 
Published: June 2005

SYNOPSISThe oral administration of d‐amphetamine with propranolol led to an immediate improvement of 161 out of 163 treated headache patients. Total disappearance of headache and other associated symptoms occurred after a few days. No relapses were observed while on this therapy. This therapeutic trial lasted 16 months and indicated the safety of the treatment. The addition of the beta‐blocker propranolol appears necessary to counteract undesirable side effects of amphetamines. Low doses of d‐amphetamine are necessary for therapeutic success. We suggest that headache and depression are due to a predominance of the serotonergic over the noradrenergic system. Activation of the serotonergic system could be triggered by beta‐adrenergic effects of the noradrenergic system. We postulate also that serotonin acts like a weak alpha‐adrenergic agonist and competes with nor‐epinephrine for alpha‐receptors on cell membranes. Low doses of d‐amphetamine, by stimulating the noradrenergic system only, and propranolol by interfering with serotonin synthesis in neurons, reestablish normal physiologic conditions.
HEADACHE IN GENERAL PRACTICE
Authors: Philips Clare 
Published: June 2005

SYNOPSISCharacteristics of headache sufferers and their headaches were investigated in a random sample of general practice patients by way of postal questionnaire.The results are consistent with previous studies in respect to prevalence, and the relation of headache to sex, age, and social class. Features of headache were found to be more closely associated with headache severity and sufferer's sex, than diagnositic group. Little justification was found for sharp division into migraine and muscle tension groups.