bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peranan Kerajaan Dalam Pendidikan Antirasuah Di Malaysia Dan Impaknya Terhadap Masyarakat
Authors: Rahman Azman Ab , Abd Aziz Md Yunus , Salleh Ahmad Zaki , Kamarulzaman Anis Nabilah 
Published: January 2024

Rasuah merupakan fenomena sosial yang telah diwarisi oleh hampir setiap masyarakat sejak awal peradaban. Ia menjadi isu yang polemik dan hangat diperkatakan serta merosakkan imej terhadap negara. Menurut laporan SPRM, statistik jumlah tangkapan dari tahun 2014 sehingga 2021 berlaku kenaikan setiap tahun iaitu 552 kes kepada 847 kes. Bahkan Malaysia turut mencatatkan kehilangan hampir RM 1.8 trillion disebabkan kegiatan amalan rasuah. Justeru artikel ini membincangkan peranan kerajaan dalam memerangi rasuah di Malaysia. Artikel ini juga akan mengkaji usaha dan inisiatif kerajaan dalam pendidikan antirasuah serta meneliti impak pendidikan antirasuah terhadap pelajar dan masyarakat di Malaysia. Kajian ini adalah kajian kualitatif dan pengumpulan data menggunakan kaedah pemerhatian dan analisis dokumen. Hasil kajian mendapati bahawa program pendidikan antirasuah amat penting dalam membendung isu rasuah yang berlaku pada hari ini. Justeru menjadi satu perkara yang penting bagi kerajaan dalam memberi kesedaran di peringkat awal pembelajaran melalui pendedahan pendidikan antirasuah dalam silibus belajar dan program bagi mengelakkan rasuah berleluasa.
DESAIN KOMUNIKASI DALAM UPAYA MENYELESAIKAN KONFLIK ANTAR AKTOR PADA KASUS PULAU REMPANG
Authors: Octavyanida Ni’matus Gesa , Putri Tiara Cahaya , Fathurrahman Reza 
Published: January 2024

This study discusses the role of the government in providing public services and infrastructure development to increase economic growth and community productivity. The case study focuses on the development of Rempang Eco City in Indonesia, which faced challenges due to the lack of involvement of the local community and the reliance on technical aspects only. The relocation efforts did not consider the social and emotional aspects of the community, leading to conflicts and human rights violations. It highlights the need for an effective communication strategy involving multi-actors to ensure that development projects are sustainable and do not discriminate against local indigenous populations. The government, indigenous communities, and BP Batam need to understand each other's interests and concerns to minimize the emergence of sectoral egos, dominance, and asymmetric information. The research study used a qualitative approach with descriptive methods to explore the conflict between sectors on Rempang Island. Data collection was conducted through document study, gathering information from various credible secondary sources. The data analysis was descriptive, aiming to provide an interpretation of the conflicts and their implications. The theoretical basis of the text is the importance of effective communication in policy formulation and implementation, which is crucial for the proper functioning of democracy in a developing country like Indonesia.
Circulating IL-6 and not its circulating signaling components sIL-6R and sgp130 demonstrate clinical significance in NSCLC patients treated with immune checkpoint inhibitors
Authors: Nakahara Yoshiro , Kouro Taku , Motoyama Satoru , Miura Masatomo , Fujita Kazuma , Igarashi Yuka , Higashijima Naoko , Matsuo Norikazu , Himuro Hidetomo , Wei Feifei , Horaguchi Shun , Tsuji Kayoko , Mano Yasunobu , Komahashi Mitsuru , Saito Haruhiro , Azuma Koichi , Sasada Tetsuro 
Published: January 2024

Introduction: Clinical roles of plasma IL-6 levels have been reported in patients with various cancers, including non-small cell lung cancer (NSCLC), treated with immune checkpoint inhibitors (ICIs). However, the roles of other IL-6 signaling components, soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130), in the plasma have not been elucidated.Methods: Blood was collected from 106 patients with NSCLC before initiation of ICI treatment (anti-PD-1 or anti-PD-L1 antibody). Plasma levels of IL-6, sIL-6R, sgp130, and their complexes were assessed by Cox regression hazard model to evaluate their clinical significance. The clinical role of IL-6 or IL-6R genetic polymorphisms was also analyzed.Results: Cox regression analysis showed that higher plasma IL-6 levels significantly predicted unfavorable overall survival (OS; hazard ratio [HR] 1.34, 95% confidence interval [CI] 1.05–1.68, p = 0.012) in NSCLC patients treated with ICIs. However, plasma sIL-6R and sgp130 levels showed no prognostic significance (p = 0.882 and p = 0.934, respectively). In addition, the estimated concentrations of binary IL-6:sIL-6R and ternary IL-6:sIL-6R:sgp130 complexes and their ratios (binary/ternary complex) were not significantly associated with OS (p = 0.647, p = 0.727, and p = 0.273, respectively). Furthermore, the genetic polymorphisms of IL-6 (−634G&gt;C) and IL-6R (48892A&gt;C) showed no clinical role by Kaplan-Meier survival analysis (p = 0.908 and p = 0.639, respectively).Discussion: These findings demonstrated the clinical significance of plasma levels of IL-6, but not of other IL-6 signaling components, sIL-6R and sgp130, suggesting that classical IL-6 signaling, but not trans-signaling, may be related to anti-tumor immune responses in cancer patients treated with ICIs.
Plant mediated synthesis of flower-like Cu2O microbeads from Artimisia campestris L. extract for the catalyzed synthesis of 1,4-disubstituted 1,2,3-triazole derivatives
Authors: Abdelbaki Halla , Djemoui Amar , Souli Lahcene , Souadia Ahmed , Ouahrani Mohammed Ridha , Djemoui Brahim , Lahrech Mokhtar Boualem , Messaoudi Mohammed , Ben Amor Ilham , Benarfa Adel , Alsalme Ali , Bechelany Mikhael , Barhoum Ahmed 
Published: January 2024

This study presents a novel method for synthesizing 1,4-disubstituted 1,2,3-triazole derivatives through a one-pot, multi-component addition reaction using flower-like Cu2O microbeads as a catalyst. The flower-like Cu2O microbeads were synthesized using an aqueous extract of Artimisia Campestris L. This extract demonstrated the capability to reduce and stabilize Cu2O particles during their initial formation, resulting in the formation of a porous flower-like morphology. These Cu2O microbeads exhibit distinctive features, including a cubic close-packed (ccp) crystal structure with an average crystallite size of 22.8 nm, bandgap energy of 2.7 eV and a particle size of 6 µm. Their catalytic activity in synthesizing 1,4-disubstituted 1,2,3-triazole derivatives was investigated through systematic exploration of key parameters such as catalyst quantity (1, 5, 10, 15, 20, and 30 mg/mL), solvent type (dimethylformamide/H2O, ethanol/H2O, dichloromethane/H2O, chloroform, acetone, and dimethyl sulfoxide), and catalyst reusability (four cycles). The Cu2O microbeads significantly increased the product yield from 20% to 85.3%. The green synthesis and outstanding catalytic attributes make these flower-like Cu2O microbeads promising, efficient, and recyclable catalysts for sustainable and effective chemical transformations.
Gender disparities in patients undergoing extracorporeal cardiopulmonary resuscitation
Authors: Springer A. , Dreher A. , Reimers J. , Kaiser L. , Bahlmann E. , van der Schalk H. , Wohlmuth P. , Gessler N. , Hassan K. , Wietz J. , Bein B. , Spangenberg T. , Willems S. , Hakmi S. , Tigges E. 
Published: January 2024

IntroductionThe use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in extracorporeal cardiopulmonary resuscitation (eCPR) has emerged as a treatment option for selected patients who are experiencing refractory cardiac arrest (CA). In the light of increasing availability, the analyses of outcome-relevant predisposing characteristics are of growing importance. We evaluated the prognostic influence of gender in patients presenting with out-of-hospital cardiac arrest (OHCA) treated with eCPR.MethodsWe retrospectively analysed the data of 377 consecutive patients treated for OHCA using eCPR in our cardiac arrest centre from January 2016 to December 2022. The primary outcome was defined as the survival of patients until they were discharged from the hospital, with a favourable neurological outcome [cerebral performance category (CPC) score of ≤2]. Statistical analyses were performed using baseline comparison, survival analysis, and multivariable analyses.ResultsOut of the 377 patients included in the study, 69 (21%) were female. Female patients showed a lower prevalence rate of pre-existing coronary artery disease (48% vs. 75%, p &lt; 0.001) and cardiomyopathy (17% vs. 34%, p = 0.01) compared with the male patients, while the mean age and prevalence rate of other cardiovascular risk factors were balanced. The primary reason for CA differed significantly (female: coronary event 45%, pulmonary embolism 23%, cardiogenic shock 17%; male: coronary event 70%, primary arrhythmia 10%, cardiogenic shock 10%; p = 0.001). The prevalence rate of witnessed collapse (97% vs. 86%; p = 0.016) and performance of bystander CPR (94% vs. 85%; p = 0.065) was higher in female patients. The mean time from collapse to the initiation of eCPR did not differ between the two groups (77 ± 39 min vs. 80 ± 37 min; p = 0.61). Overall, female patients showed a higher percentage of neurologically favourable survival (23% vs. 12%; p = 0.027) despite a higher prevalence of procedure-associated bleeding complications (33% vs. 16%, p = 0.002). The multivariable analysis identified a shorter total CPR duration (p = 0.001) and performance of bystander CPR (p = 0.03) to be associated with superior neurological outcomes. The bivariate analysis showed relevant interactions between gender and body mass index (BMI).ConclusionOur analysis suggests a significant survival benefit for female patients who obtain eCPR, possibly driven by a higher prevalence of witnessed collapse and bystander CPR. Interestingly, the impact of patient age and BMI on neurologically favourable outcome was higher in female patients than in male patients, warranting further investigation.
School improvement and peer learning partnerships: building organizational resilience in primary schools in England
Authors: Godfrey David , Munoz-Chereau Bernardita 
Published: January 2024

IntroductionThis article looks at organizational resilience (OR) through the analysis of a sub-set of data gained from an independent and embedded mixed methods implementation and process evaluation (IPE) of the Schools Partnership Program (SPP) implemented over 3 years (2018–2021) and funded by the Education Endowment Foundation (EEF) in England. We describe ways in which SPP ‘learning map’ addresses the (i) anticipation, (ii) coping and (iii) adaptation stages and the extent to which SPP helped building organizational resilience. Taking this theoretical framework as a foundation is a novelty, as despite OR has become prominent in the academic literature apart from a few exceptions there is a dearth of international research examining OR within the school sector.MethodsA sample of 422 primary schools that took part in SPP (treatment schools) and their comparisons are analyzed applying the organizational capability-based framework. Drawing on SPP empirical data from numerous data collection strategies (interviews, surveys, shadowing school reviews and improvement workshops), the extent to which schools’ resilience capacities were improved is analyzed.ResultsOur findings suggest that SPP supported the development of OR in SPP primary schools. Despite facing several challenging external factors (student deprivation, the COVID disruption, changes to the external accountability framework and competing demands of other partner organizations) and internal factors (teacher attrition, need to developing leaders, upgrade pedagogical skills and encourage student subgroups who were underperforming) SPP schools exert (1) knowledge building through training, the review process, professional dialogue, learning from each other, as well as receiving and giving feedback. Regarding (2) resource availability, schools used SPP as a scaffold to build improvised strategies to access and mobilize shared human and physical resources; (3) social resources were built in the SPP through social capital, sharing of knowledge, enhancing a shared vision and trust. Finally, (4) SPP promoted lateral power dynamics driven by professional learning and accountability.DiscussionOverall, the paper extends the understanding of school peer review approaches for school improvement and adds to the OR international literature by presenting features that extend it toward building system resilience.
Performance evaluation of solar PV mini grid system in Nepal: a case study Thabang and Sugarkhal
Authors: Karna Sanjay Lal , Jha Ajay Kumar , Yadav Kishori , Kumar Mallik Jiwan 
Published: January 2024

This article investigates the performance metrics of two solar mini-grid systems, Thabang Solar Mini-Grid (TSMG) and Sugarkhal Solar Mini-Grid (SSMG), based on secondary live data, collected from Renewable Energy for Rural Livelihood (RERL) and PVsyst software 7.4 spanning the years 2021–2023. Notably, the highest irradiance levels were recorded in April for both TSMG and SSMG. TSMG exhibited an energy generation of 83.206 MWh/year in 2021 and 112.140 MWh/year in 2022, with a peak sun hour (PSH) of 5.5 h. Conversely, SSMG energy generated 64.14 MWh/year in 2021 and 68.79 MWh/year in 2022, with a PSH of 5.7 h. The capture loss of SSGM recorded 0.239 kWh/day to 3.322 kWh/day in 2021 and 0.082 kWh/day to 2.086 kWh/day in 2022. Also, the capture loss of TSGM recorded 1.573 kWh/day to 5.011 kWh/day in 2021 and 0.470 kWh/day to 4.261 kWh/day in 2023. The efficiency of SSMG is consistently higher efficiency compared to TSMG. The capture factor of SSMG increased from 9.76% in 2021 to 10.47% in 2022, while of TSMG 6.33% in 2021 to 8.53% in 2023. The findings provide valuable insights into the comparative performance of these solar mini-grid systems, contributing to the optimization and improvement of solar energy generation in diverse environmental conditions.
Safety and efficacy of COVID-19 vaccine immunization during pregnancy in 1024 pregnant women infected with the SARS-CoV-2 Omicron virus in Shanghai, China
Authors: Deng Hongmei , Jin Yinpeng , Sheng Minmin , Liu Min , Shen Jie , Qian Wei , Zou Gang , Liao Yixin , Liu Tiefu , Ling Yun , Fan Xiaohong 
Published: January 2024

BackgroundLarge sample of pregnant women vaccinated with COVID-19 vaccine has not been carried out in China. The objective of this study was to evaluate the safety and effectiveness of COVID-19 inactivated vaccine in pregnant women infected with the SARS-CoV-2 Omicron variant.MethodsA total of 1,024 pregnant women and 120 newborns were enrolled in this study. 707 pregnant women received one to three doses of the inactivated COVID-19 vaccine, and 317 unvaccinated patients served as the control group. A comparison was made between their clinical and laboratory data at different stages of pregnancy.ResultsThe incidence rate of patients infected with Omicron variant in the first, the second, and the third trimesters of pregnancy was 27.5%, 27.0%, and 45.5% in patients during, respectively. The corresponding length of hospital stay was 8.7 ± 3.3 days, 9.5 ± 3.3 days, and 11 ± 4.3 days, respectively. The hospitalization time of pregnant women who received 3 doses of vaccine was (8.8 ± 3.3) days, which was significantly shorter than that of non-vaccinated women (11.0 ± 3.9) days. (P&lt;0.0001). The positive rate of SARS-CoV-2 IgG in patients in the early stage of pregnancy was 28.8%, while that in patients in the late stage of pregnancy was 10.3%. However, three-doses of vaccination significantly increased the SARS-CoV-2 IgG positive rate to 49.5%. The hospitalization time of SARS-CoV-2 IgG-positive patients was shorter than that of negative patients (9.9 ± 3.5 days), which was 7.4 ± 2.0 days. 12.2% of vaccinated women experienced mild adverse reactions, manifested as fatigue (10.6%) and loss of appetite (1.6%). The vaccination of mother did not affect her choice of future delivery mode and the Apgar score of their newborn. All newborns tested negative for SARS-CoV-2 nucleic acid, as well as for IgG and IgM antibodies.ConclusionsWomen in the third trimester of pregnancy are highly susceptible to infection with the Omicron strain. The vaccination of pregnant women with COVID-19 vaccine can accelerate the process of eliminating SARS-CoV-2 virus, and is considered safe for newborns. The recommended vaccination includes three doses.
Analysis of clinical characteristics and factors influencing herpes simplex virus keratitis
Authors: Zhang Shuai , Mi Jinhua , Ge Shengmei , Wang Guoqiang , Zhou Zhongyou , Zhao Yantao , Zhao Yan 
Published: January 2024

ObjectiveTo investigate the clinical characteristics and factors associated with herpes simplex virus keratitis.MethodsPatients with herpes simplex virus keratitis who came to our hospital from January 2018 to June 2022 were selected and divided into a good prognosis group and a poor prognosis group according to their prognosis. The clinical data of the two groups were compared, and univariate/multivariate logistic regression was used to analyze the factors influencing the poor prognosis of herpes simplex virus keratitis.ResultsA one-way analysis of variance showed that, compared with the good prognosis group, the poor prognosis group had more elderly patients and a longer course of disease, and the difference was statistically significant (p &lt; 0.05). There were significant differences in the types of patients between the two groups (p &lt; 0.05). Univariate logistic regression analysis also showed that age (≥65 years) (OR: 1.557, 95%CI: 1.081–2.183, p &lt; 0.05), course of disease (&gt; 7 months) (OR: 1.303, 95%CI: 1.003–1.829, p &lt; 0.05), epithelial type (OR: 2.321, 95%CI: 1.198–4.321, p &lt; 0.05), and stromal type (OR: 2.536, 95%CI: 1.672–3.871, p &lt; 0.05) were risk factors for poor prognosis. Multivariate logistic regression analysis showed that age (≥65 years) (OR: 1.656, 95%CI: 1.168–2.357, p &lt; 0.05) and course of disease (&gt; 7 months) (OR: 1.461, 95%CI: 1.031–2.001, p &lt; 0.05) were independent risk factors for the prognosis of herpes simplex keratitis.ConclusionThe clinical symptoms of herpes simplex virus keratitis include corneal opacity, corneal posterior elastic layer folds, corneal infiltration, posterior corneal mass, corneal edema, and ocular pain. Age and course of disease are important factors in the prognosis of herpes simplex virus keratitis.
Perinatal outcome and timing of selective fetal reduction in dichorionic diamniotic twin pregnancies: a single-center retrospective study
Authors: Zou Gang , Ji Qingfang , Chen Jianping , Zhang Luye , Sun Qianqian , Shi Yaqi , Yang Yingjun , Zhou Fenhe , Wei Xing , Sun Luming 
Published: January 2024

ObjectiveThe study aimed to evaluate the pregnancy outcomes of dichorionic diamniotic twin pregnancies that were reduced to singletons at different gestational ages.Study designThis was a retrospective cohort study of twin pregnancies that underwent fetal reduction to singletons in a single tertiary referral center between 2011 and 2020. A total of 433 cases were included. The cohort was divided into five groups according to gestational age at surgery: Group A: &lt;16 weeks (125 cases); Group B: 16–19+6 weeks (80 cases); Group C: 20–23+6 weeks (74 cases); Group D: 24–26+6 weeks (48 cases); and Group E: ≥27 weeks (106 cases). Outcome data were obtained by reviewing the electronic medical records or interviews.ResultsSelective reduction was technically successful. The clinical characteristics of the population were not different. The overall live birth rate and the survival rate were 96.5 and 95.4%, respectively. Although the rate of spontaneous miscarriage was comparable, gestational age at delivery significantly differed among groups (p &lt; 0.001). Additionally, there was a trend that gestational age at delivery decreased with the increasing gestational age at surgery in Groups A, B, C, and D, whereas gestational age at delivery in Group E was later than that in Group D. In Groups A, B, C, and D, the rates of preterm birth at &lt;32 weeks and &lt;34 weeks increased with the increasing gestational age at surgery, while the rates in Group E were significantly lower than that in Group D. Regression analysis showed that timing of reduction may be an independent factor after adjusting for maternal age, parity, pre-pregnancy BMI, ART, and cervical length.ConclusionSelective reduction performed by experienced hands for a dizygotic abnormal twin is safe and effective. Gestational age at surgery (&lt;26+6 weeks) was inversely correlated with gestational age at delivery and positively with the rate of preterm birth. Reduction after 27 weeks, where legal, can be performed with a good outcome for the retained fetus.
Long-term bilateral change in pain and sensitivity to high-frequency cutaneous electrical stimulation in healthy subjects depends on stimulus modality: a dermatomal examination
Authors: Escobar-Sánchez Isabel , Ríos-León Marta , Taylor Julian 
Published: January 2024

IntroductionContradictory changes in pain and sensitivity at long-term following cutaneous 100 Hz high frequency stimulation (HFS) have been previously observed. Thus, we aimed to document long-lasting changes in multimodal sensitivity following HFS, and factors influencing them.MethodsLong-lasting changes were assessed with mechanical [brush, von Frey filament (588.2 mN)] and thermal [heat (40°C)/cold (25°C)] bedside sensory testing, and electrical TS (0.2 ms single electrical stimuli), at the homotopic (ipsilateral C6 dermatome), adjacent heterotopic (ipsilateral C5 and C7 dermatomes) and contralateral (contralateral C6 dermatomes) dermatomal sites in a single testing session. TS were applied before and after application of 100 Hz HFS at the ipsilateral C6 dermatome. Subjects rated their sensation and pain intensity to TS, and completed questionnaires related to pain descriptors and quality of life.ResultsLong-lasting changes in mechanical and cold sensitivity was detected up to 45 min after HFS at homotopic C6 dermatome, and a temporary increase in cold sensitivity at 20 min in the contralateral C6 dermatome (p &lt; 0.05). A slow development of bilateral depotentiation to electrical pain TS was also detected from 40 min after HFS (p &lt; 0.05). Higher HFS-induced mechanical and cold sensitivity was identified in women (p &lt; 0.05). Age and quality of life were associated with pain intensity (p &lt; 0.05).ConclusionLong-term unilateral and bilateral changes in sensation and pain following electrical HFS have been found. These findings may suggest a new insight into the development of persistent pain mechanisms. Further studies are now needed.