bluuebunny/crossref_metadata_2025_split huggingface dataset:
The microneme adhesive repeat domain of MIC3 protein determined the site specificity of Eimeria acervulina, Eimeria maxima, and Eimeria mitis
Authors: Zhang Yang , Lu Mingmin , Zhang Zhenchao , Huang Xinmei , Huang Jingwei , Liu Jiabin , Huang Jianmei , Song Xiaokai , Xu Lixin , Yan Ruofeng , Li Xiangrui 
Published: November 2023

Understanding the determinants of host and tissue tropisms among parasites of veterinary and medical importance has long posed a substantial challenge. Among the seven species of Eimeria known to parasitize the chicken intestine, a wide variation in tissue tropisms has been observed. Prior research suggested that microneme protein (MIC) composed of microneme adhesive repeat (MAR) domain responsible for initial host cell recognition and attachment likely dictated the tissue tropism of Eimeria parasites. This study aimed to explore the roles of MICs and their associated MARs in conferring site-specific development of E. acervuline, E. maxima, and E. mitis within the host. Immunofluorescence assays revealed that MIC3 of E. acervuline (EaMIC3), MIC3 of E. maxima (EmMIC3), MIC3 of E. mitis (EmiMIC3), MAR3 of EaMIC3 (EaMIC3-MAR3), MAR2 of EmMIC3 (EmMIC3-MAR2), and MAR4 of EmiMIC3 (EmiMIC3-MAR4), exhibited binding capabilities to the specific intestinal tract where these parasites infect. In contrast, the invasion of sporozoites into host intestinal cells could be significantly inhibited by antibodies targeting EaMIC3, EmMIC3, EmiMIC3, EaMIC3-MAR3, EmMIC3-MAR2, and EmiMIC3-MAR4. Substitution experiments involving MAR domains highlighted the crucial roles of EaMIC3-MAR3, EmMIC3-MAR2, and EmiMIC3-MAR4 in governing interactions with host ligands. Furthermore, animal experiments substantiated the significant contribution of EmiMIC3, EmiMIC3-MAR4, and their polyclonal antibodies in conferring protective immunity to Eimeria-affiliated birds. In summary, EaMIC3, EmMIC3, and EmiMIC3 are the underlying factors behind the diverse tissue tropisms exhibited by E. acervuline, E. maxima, and E. mitis, and EaMIC3-MAR3, EmMIC3-MAR2, and EmiMIC3-MAR4 are the major determinants of MIC-mediated tissue tropism of each parasite. The results illuminated the molecular basis of the modes of action of Eimeria MICs, thereby facilitating an understanding and rationalization of the marked differences in tissue tropisms among E. acervuline, E. maxima, and E. mitis.
Increased cranio-caudal spinal cord oscillations are the cardinal pathophysiological change in degenerative cervical myelopathy
Authors: Pfender Nikolai , Rosner Jan , Zipser Carl M. , Friedl Susanne , Schubert Martin , Sutter Reto , Klarhoefer Markus , Spirig José M. , Betz Michael , Freund Patrick , Farshad Mazda , Curt Armin , Hupp Markus 
Published: November 2023

IntroductionDegenerative cervical myelopathy (DCM) is the most common cause of non-traumatic incomplete spinal cord injury, but its pathophysiology is poorly understood. As spinal cord compression observed in standard MRI often fails to explain a patient's status, new diagnostic techniques to assess DCM are one of the research priorities. Minor cardiac-related cranio-caudal oscillations of the cervical spinal cord are observed by phase-contrast MRI (PC-MRI) in healthy controls (HCs), while they become pathologically increased in patients suffering from degenerative cervical myelopathy. Whether transversal oscillations (i.e., anterior–posterior and right–left) also change in DCM patients is not known.MethodsWe assessed spinal cord motion simultaneously in all three spatial directions (i.e., cranio-caudal, anterior–posterior, and right–left) using sagittal PC-MRI and compared physiological oscillations in 18 HCs to pathological changes in 72 DCM patients with spinal canal stenosis. The parameter of interest was the amplitude of the velocity signal (i.e., maximum positive to maximum negative peak) during the cardiac cycle.ResultsMost patients suffered from mild DCM (mJOA score 16 (14–18) points), and the majority (68.1%) presented with multisegmental stenosis. The spinal canal was considerably constricted in DCM patients in all segments compared to HCs. Under physiological conditions in HCs, the cervical spinal cord oscillates in the cranio-caudal and anterior–posterior directions, while right–left motion was marginal [e.g., segment C5 amplitudes: cranio-caudal: 0.40 (0.27–0.48) cm/s; anterior–posterior: 0.18 (0.16–0.29) cm/s; right–left: 0.10 (0.08–0.13) cm/s]. Compared to HCs, DCM patients presented with considerably increased cranio-caudal oscillations due to the cardinal pathophysiologic change in non-stenotic [e.g., segment C5 amplitudes: 0.79 (0.49–1.32) cm/s] and stenotic segments [.g., segment C5 amplitudes: 0.99 (0.69–1.42) cm/s]). In contrast, right–left [e.g., segment C5 amplitudes: non-stenotic segment: 0.20 (0.13–0.32) cm/s; stenotic segment: 0.11 (0.09–0.18) cm/s] and anterior–posterior oscillations [e.g., segment C5 amplitudes: non-stenotic segment: 0.26 (0.15–0.45) cm/s; stenotic segment: 0.11 (0.09–0.18) cm/s] remained on low magnitudes comparable to HCs.ConclusionIncreased cranio-caudal oscillations of the cervical cord are the cardinal pathophysiologic change and can be quantified using PC-MRI in DCM patients. This study addresses spinal cord oscillations as a relevant biomarker reflecting dynamic mechanical cord stress in DCM patients, potentially contributing to a loss of function.
Predicting short-term outcomes in atrial-fibrillation-related stroke using machine learning
Authors: Jeon Eun-Tae , Jung Seung Jin , Yeo Tae Young , Seo Woo-Keun , Jung Jin-Man 
Published: November 2023

BackgroundPrognostic prediction and the identification of prognostic factors are critical during the early period of atrial-fibrillation (AF)-related strokes as AF is associated with poor outcomes in stroke patients.MethodsTwo independent datasets, namely, the Korean Atrial Fibrillation Evaluation Registry in Ischemic Stroke Patients (K-ATTENTION) and the Korea University Stroke Registry (KUSR), were used for internal and external validation, respectively. These datasets include common variables such as demographic, laboratory, and imaging findings during early hospitalization. Outcomes were unfavorable functional status with modified Rankin scores of 3 or higher and mortality at 3 months. We developed two machine learning models, namely, a tree-based model and a multi-layer perceptron (MLP), along with a baseline logistic regression model. The area under the receiver operating characteristic curve (AUROC) was used as the outcome metric. The Shapley additive explanation (SHAP) method was used to evaluate the contributions of variables.ResultsMachine learning models outperformed logistic regression in predicting both outcomes. For 3-month unfavorable outcomes, MLP exhibited significantly higher AUROC values of 0.890 and 0.859 in internal and external validation sets, respectively, than those of logistic regression. For 3-month mortality, both machine learning models exhibited significantly higher AUROC values than the logistic regression for internal validation but not for external validation. The most significant predictor for both outcomes was the initial National Institute of Health and Stroke Scale.ConclusionThe explainable machine learning model can reliably predict short-term outcomes and identify high-risk patients with AF-related strokes.
Emerging trends and hot spots of sleep and genetic research: a bibliometric analysis of publications from 2002 to 2022 in the field
Authors: Tao Ying , Qin Yi , Chen Sifan , Xu Tian , Lin Junhui , Su Diansan , Yu Weifeng , Chen Xuemei 
Published: November 2023

BackgroundSleep is an important biological process and has been linked to many diseases; however, very little is known about which and how genes control and regulate sleep. Although technology has seen significant development, this issue has still not been adequately resolved. Therefore, we conducted a bibliometric analysis to assess the progress in research on sleep quality and associated genes over the past 2 decades. Through our statistical data and discussions, we aimed to provide researchers with better research directions and ideas, thus promoting the advancement of this field.MethodsOn December 29, 2022, we utilized bibliometric techniques, such as co-cited and cluster analysis and keyword co-occurrence, using tools such as CiteSpace, VOSviewer, and the Online Analysis Platform of Literature Metrology (http://bibliometric.com/), to conduct a thorough examination of the relevant publications extracted from the Web of Science Core Collection (WoSCC). Our analysis aimed to identify the emerging trends and hot spots in this field while also predicting their potential development in future.ResultsCluster analysis of the co-cited literature revealed the most popular terms relating to sleep quality and associated genes in the manner of cluster labels; these included genome-wide association studies (GWAS), circadian rhythms, obstructive sleep apnea (OSA), DNA methylation, and depression. Keyword burst detection suggested that obstructive sleep apnea, circadian clock, circadian genes, and polygenic risk score were newly emergent research hot spots.ConclusionBased on this bibliometric analysis of the publications in the last 20 years, a comprehensive analysis of the literature clarified the contributions, changes in research hot spots, and evolution of research techniques regarding sleep quality and associated genes. This research can provide medical staff and researchers with revelations into future directions of the study on the pathological mechanisms of sleep-related diseases.
Predictors of length of hospital stay for preterm infants in Ethiopia: a competing risk analysis
Authors: Bonger Zelalem Tazu , Mamo Biniyam Tedla , Birra Sosna Bayu , Yalew Alemayehu Worku 
Published: November 2023

BackgroundLength of hospital stay (LOS) is one of the essential indicators for evaluating the efficiency and the quality-of-care service delivered. predicting LOS is critical for resource allocation, decision-making, lowering neonatal morbidity and death, enhancing clinical outcomes and parent counseling. In addition, extended hospital stays (long LOS_NICU) place a burden on the healthcare systems decreasing bed turnover rates as well as their financial stand and the mental stress on families. In Ethiopia, there is limited evidence on the determinant factors that influence on LOS.ObjectivesTo determine factors affecting neonatal intensive care unit length of stay for all preterm newborns who were discharged alive.MethodThe study used a secondary data source, was collected for the Study of Illness in Preterm (SIP) infants project. The research study was a multicenter, cross-sectional, observational clinical study that took place in five Ethiopia hospitals from July 1, 2016, to May 31, 2018. The predictors of LOS were determined using Fine-Gray's competing risk analysis.ResultsFor this study 3,511 preterm infants admitted to the NICU were analyzed. About 28.8% of the preterm infants died during their time in neonatal care while 66.6% were discharged alive. At the end of the study 4.6% babies were still in the NICU. The overall median LOS (death or discharge) was 7 days, with an interquartile range of 8 days. The cumulative incidence of discharge rose with increasing in gestational age and birth weight, on the contrary, the rate of discharge was decreased by 45.7% with the development of RDS (SDH ratio: 0.543), by 75.9% with the development of apnea (SDH ratio: 0.241), by 36.2% with sepsis, and by 43.6% with pneumonia (SDH ratio: 0.564).ConclusionsPreterm newborns with a low gestational age and birth weight have a greater probability of having a prolonged LOS. Complications of the medical conditions RDS, apnea, sepsis, pneumonia, anemia, asphyxia, and NEC substantially raise LOS considerably.
Efficacy of RUTI® immunotherapy against active tuberculosis in a mouse model challenges the Koch phenomenon
Authors: Soldevilla Pablo , Buisan Anna , Diaz Jorge , Saladrigas Sergi , Rosales Yaiza , Arias Lilibeth , Jimenez-Melsio Alexandra , Vilaplana Cristina , Amat Fabregat Merce , Cardona Pere-Joan 
Published: November 2023

ObjectivesThe objective of this study was to evaluate the safety and efficacy of the therapeutic vaccine RUTI® with or without the standard of care (SOC) chemotherapy for TB in an experimental murine model.MethodsWe assessed the efficacy of RUTI®, a vaccine based on pasteurized and freeze-dried cell-wall fragments from Mycobacterium tuberculosis (Mtb), the SOC for sensitive TB (isoniazid, rifampicin, ethambutol, and pyrazinamide) in the murine active TB model in C3HeB/FeJ strain (Kramnik model). We evaluated the bacillary load in the lungs and spleen, the immune response against specific Mtb antigens (PPD, HSP16.3, ESAT-6, and PsTS1), and lung damage in paraffined tissues for qualitative and quantitative analysis.ResultsRUTI® significantly reduces the pulmonary damage (x3) and the bacterial burden in the lungs (1.5 log10) and spleen (1 log10), and maintains the cellular immune response against ESAT-6, compared to SOC. There was also an additive effect when administered in combination with SOC, increasing the reduction of the lung damage (x2), the bacillary load in lungs (1 log10) and increasing the immune response against PPD, HSP16.3 and PsTS1.DiscussionTherapeutic vaccination against TB has been avoided for decades due to fear of toxicity through the Koch phenomenon. These data show for the first time the safety of immunotherapy with Mtb antigens in an active TB model, adding efficacy to SOC. This encourages the beginning of clinical studies to evaluate the safety and efficacy of RUTI® in TB patients to improve their health, reduce its potential infectiousness, and reduce the length of treatment.
TiO2/Arabic Gum for Degradation of Pollutants in Water
Authors: Lopes Anderson , Araújo Francisca P. , Damasceno Dihego , Honório Luzia M. C. , Morais Alan I. S. , Almeida Luciano C. , Garcia Ramón Peña , Silva-Filho Edson C. , Furtini Marcelo B. , Osajima Josy A. 
Published: November 2023

Emerging contaminants and pollution are environmental problems threatening public health. Antibiotic ciprofloxacin and methylene blue dye are pollutants frequently detected in water systems worldwide. Photocatalysis is a process for water treatment. TiO2-based catalysts synthesized with natural gums show improved photocatalytic properties. Here, the sol–gel method synthesized TiO2/Arabic gum for photocatalytic performance. The innovation of this work was synthesized at 400 °C and investigated their photocatalytic proprieties using methylene blue and ciprofloxacin as model pollutants. XRD showed that the photocatalyst was in the anatase phase. The result showed that TiO2 with a band gap of 3.29 eV was achieved at a calcination temperature of 400 °C. Corresponding FTIR results suggest only the existence of functional groups related to TiO2. The SEM and BET method characterization indicated that TiO2/Arabic gum were spherical-shaped nanoparticles arranged in clusters with a mesoporous structure, contributing to photocatalytic performance. In addition, photocatalytic studies showed that the methylene blue dye and ciprofloxacin antibiotic degradation rates reached 99% and 94% under UV light, respectively. The hole (h+) and OH ⦁ radicals are essential in photodegradation. The synthesized material showed excellent photostability and maintained almost the same degradation percentage in the three consecutive cycles tested on the different pollutants. The TiO2/Arabic gum is an excellent candidate for future use in treating contaminants in aqueous media using photocatalysis. Therefore, TiO2/Arabic gum nanoparticles are a promising material for wastewater treatment.
La Cène est-elle la vraie icône du Christ ? (aux origines du dogme eucharistique)
Authors: Pérès Jacques-Noël 
Published: November 2023

Prenant comme point de départ le Concile de Nicée II (7S7) qui condamne l'iconoclasme, Jacques-Noël Pérès s'interroge sur le rapport entre l'image et l'eucharistie : le synode de Hiéria (754) n'a-t-il pas parlé de ce sacrement comme de la seule vraie image du Christ ?
Il expose les différentes positions que, du IXe au XIIe s., adoptent les théologiens de l'Église franque, et en souligne le caractère médiateur.
Introduction aux lectures féministes de la christologie
Authors: Van de Kerk Arina 
Published: November 2023

Jésus a été un homme : ce détail biographique est devenu un élément constitutif de la christologie et lui a permis de justifier l’exclusion des femmes des ministères de l’Église.
Arina Van de Kerk montre pourquoi des théologiennes travaillant dans une perspective féministe contestent la légitimité des interprétations andocentriques de la christologie. Pour ce faire, elles se réfèrent au Jésus des Évangiles et mettent en cause la divinisation du Christ.
L’ecclésiologie en héritage : de l’impasse au passage
Authors: Graesslé Isabelle 
Published: November 2023

Le contexte dans lequel se déploie le christianisme aujourd’hui, du moins en Europe occidentale, oblige à se poser la question de sa visibilité, de sa parole et de sa pertinence. A l’heure de la recomposition du religieux, n’est-il pas temps de reprendre le travail ecclésiologique et de proposer, au moins comme hypothèse, un fondamental changement de paradigme ecclésial ?
Après une reprise critique des traditionnelles «marques de l’Église», à propos desquelles un moratoire est préconisé, et une brève présentation de l’ecclésiologie féministe, modèle d’une réflexion «en passage», Isabelle Graesslé délimite les sites du passage : l’espace de l’Église, le sens et la fonction de la communauté chrétienne, le renouvellement des images, la mission, la spiritualité.
THE WORKERS’CONTRIBUTION’S FACTORS TOWARD SOCIAL ENTERPRISE
Authors: Makerd Pawaris , Siriwichai Chalermporn 
Published: November 2023

This research examines the trends and elements of workers' contributions to social enterprises. The research applies the quantitative research method, the sample size calculated from G power 3.1.9, Pearson's correlation the sufficient sample size must be greater than 312. The reviewed questionnaire was used to collect data and analyzed using the descriptive and Pearson's correlation
Research result: most of the respondent is female, aged between 41-45, married, has no children, with college/university background education, income between 10,001-20,000 Baht, experienced job changes 1-2 times, and obtained 1 - 3 years the current job experience.
Respondents' perception of Intrinsic Factors and Achievement of the outcome of Extrinsic Factors are considered the most significant factors. The respondent's perception of Extrinsic Factors and Organizational Context is likely the same. Social enterprise worker contributions seem to be a less important issue than others.
THz wave Mux/DeMux operation using bearded-type topological photonic crystal waveguide structure
Authors: Hata Remma , Fujikata Junichi 
Published: November 2023

Abstract
Terahertz (THz)wave wireless communication technologies have been developed to increase transmission capacity in 6G communications. Although the realization of integrated waveguides in THz wave transmitters and receivers is essential, bending loss in THz waveguides is important as well. This study investigated a THz waveguide based on a valley photonic crystal (VPC) structure. We numerically investigated a THz waveguide with sharp bending and Mux/DeMux filters based on the oblique rectangular resonator of a bearded-type VPC waveguide.
Modulation of Point Spread Function for Super-Resolution Imaging
Authors: Lu Jian-yu 
Published: November 2023

<p>A four-dimensional (4D) super-resolution imaging method (called PSF modulation method) was developed via modulation of an arbitrary point-spread-function (PSF) of an imaging system. The highest image resolution achievable will only be limited by the noises in the images. Theory, computer simulations, and experiments were presented. </p>
<p>A pulse-echo image of a super-resolution (0.65 mm versus a two-way diffraction-limited resolution of 2.65 mm) and 31-dB signal-to-noise ratio (SNR) was obtained with an ultrasound experiment using a 0.5-mm diameter modulator and 1.483-mm wavelength. Another ultrasound experiment shows that a wave source was imaged at a super-resolution (0.5 mm versus a one-way diffraction limited resolution of 3.63 mm) at about 30-dB SNR, using the same modulator size and wavelength. </p>
<p>In addition, a PSF-weighted super-resolution imaging method based on the PSF modulation method was developed. This method is easier to implement but may have some limitations. With a proper choice of a modulator and imaging system, nanoscale imaging is possible using the methods developed. </p>
Tad: A Domain-Aware Framework Learning to Adapt Target Shifts of Hate Speech
Authors: Xi Ruijie , Yuan Jiaqing , Singh Munindar P. 
Published: November 2023

<p>Hate speech targets different social groups such as race and gender, and poses a significant threat to social harmony. Researchers are increasingly motivated to devise efficient techniques to improve automatic hate speech detection on social media platforms. However, current models are usually evaluated without considering hate speech targets and fail when the targets are unseen in the training data.</p>
<p>In this study, we examine target (domain) shifts of hate speech and propose, \emph{Tad}, an adaptation framework for neural models that adopts domain-aware networks to improve cross-domain hate speech detection. Tad features a hate knowledge lexicon infusion network, a domain-specific network, and a weighting network. We demonstrate that incorporating Tad improves the performance of leading neural models in hate speech detection when tested on unseen domains. Specifically, Tad yields improvements of up to 8$.1\%$ and an average of $2.4\%$ in macro F1-scores. Moreover, we identify data quality and quantity as vital factors to address performance gaps between models tested on seen and unseen domains. Our results reveal that excessive knowledge infusion may result in a decrease in performance such as for \textsl{Religion}. </p>
<p>In addition, we find trade-offs in cross-domain hate speech detection. For example, weighted loss for heavily imbalanced data generally improves performance.</p>
The consequences of stress experienced by emergency department nurses during the COVID-19 emergency detected through the "Screening Questionnaire for Disaster Mental Health (SQD)", a survey conducted in a Local Health Unit in Northern Italy
Authors: Lucenti Enrico , Casella Giovanna , Schiavone Federica , Beretta Maurizio , Gheri Flavio , Gubbelini Mirella , Guasconi Massimo 
Published: November 2023

Introduction: Nurses are at high risk of developing a psychiatric disorder as a result of exposure to stressful and/or traumatic events experienced in the work time slot. Specifically, long-term depression or post-traumatic stress disorder (PTSD) could arise. The spread of the COVID-19 pandemic has subjected nurses to stressful working conditions. This research aimed to investigate the effects of mental and physical stress faced by nurses who provided assistance to the Emergency Department (ED) of the Piacenza Hospital during the COVID-19 pandemic detected through the "Screening Questionnaire for Disaster Mental Health (SQD)."
Methods: 47 nurses who provided care in the ED from March 8 to May 3, 2020 were sampled. Each nurse was asked to complete a form containing socio-demographic data and the SQD questionnaire. The study was approved by the Area Vasta Emilia Nord Ethics Committee.
Results: 88% of the sample presents "mildly likely depression," the remaining 12% present "likely depression." 67% appeared "moderately affected" by PTSD and 14% presented as "severely affected."
Conclusions: The study shows that there is a percentage of nurses with a high probability of developing depression or PTSD in stressful work situations such as those caused by the covid-19 emergency. Through these data, prevention measures such as psychological support can be proposed.