bluuebunny/crossref_metadata_2025_split huggingface dataset:
RARRES2 is involved in the “lock-and-key” interactions between osteosarcoma stem cells and tumor-associated macrophages
Authors: Ma Jingjin , Chen Zhiyu , Li Qiaochu , Wang Linbang , Chen Jiaxing , Yang Xinyu , Yang Chaohua , Quan Zhengxue 
Published: January 2024

AbstractOsteosarcoma (OS) is a type of tumor. Osteosarcoma stem cells (OSCs) are responsible for drug resistance, recurrence, and immunosuppression in OS. We aimed to determine the heterogeneity of OSCs and the immunosuppression mechanisms underlying the interactions between OSCs and tumor-associated macrophages (TAMs). The cell components, trajectory changes, and cell communication profiles of OS cells were analyzed by transcriptomics at the single-cell level. The intercellular communication patterns of OSCs were verified, and the role of the cell hub genes was revealed. Hub geneS are genes that play important roles in regulating certain biological processes; they are often defined as the genes with the strongest regulatory effect on differentially expressed gene sets. Moreover, various cellular components of the OS microenvironment were identified. Malignant cells were grouped, and OSCs were identified. Further regrouping and communication analysis revealed that the genes in the stemness maintenance and differentiation subgroups were involved in communication with macrophages. Key receptor–ligand pairs and target gene sets for cell communication were obtained. Transcriptome data analysis revealed the key gene RARRES2, which is involved in intercellular communication between OSCs and TAMs. In vitro studies confirmed that macrophages promote RARRES2-mediated stemness maintenance in OSCs via the TAM-secreted cytokine insulin-like growth factor 1. Patient studies confirmed that RARRES2 could be a biomarker of OS. OSCs are highly heterogeneous, and different subgroups are responsible for proliferation and communication with other cells. The IGF-RARRES2 axis plays a key role in maintaining OSC stemness through communication with TAMs.
Limited ability of increased sequencing depth in detecting cases missed by noninvasive prenatal testing: a comparative analysis of 3 clinical cases
Authors: Lu Yinghong , Zuo Na , Ning Minxia , Xie Yuling , Liu Weiwu , Ning Sisi , Liang Yi , Chen Xiao , Zhang Yuping , Feng Jun , Qin Yunrong 
Published: January 2024

AbstractIncreased sequencing depth can improve the detection rate of noninvasive prenatal testing (NIPT) for chromosome aneuploidies and copy number variations (CNVs). However, due to the technical limitations of NIPT, false-positives and false-negatives are inevitable. False-positives for aneuploidy and CNVs have been widely reported, but few missed cases have been reported. In this study, we report 3 patients missed by NIPT, which were still missed after increasing the sequencing depth. To verify the detection efficiency of the platform, the results of NIPT in 32,796 patients treated in Yulin Women and Children Health Care Hospital from 2020 to 2022 were retrospectively analyzed. Data on false-negative cases found by postnatal follow-up or amniocentesis were collected, and the sequencing data, pregnancy examination data, and postnatal follow-up results of these missed patients were summarized. Five patients missed by NIPT were found, and they were missed again by retesting or increasing the sequencing depth. Except for hypospadias found in 1 patient, ultrasonography of the other 4 patients showed no obvious abnormalities during the whole pregnancy. Our results suggest that pregnant women should be fully informed of the benefits and limitations of NIPT before undergoing the examination to avoid unnecessary medical disputes.
Ironing process optimization for enhanced properties in material extrusion technology using Box–Behnken Design
Authors: Alzyod Hussein , Ficzere Peter 
Published: January 2024

AbstractMaterial Extrusion (MEX) technology, a prominent process in the field of additive manufacturing (AM), has witnessed significant growth in recent years. The continuous quest for enhanced material properties and refined surface quality has led to the exploration of post-processing techniques. In this study, we delve into the ironing process as a vital processing step, focusing on the optimization of its parameters through the application of Design of Experiments (DoE), specifically the Box–Behnken Design (BBD). Through a systematic examination of ironing process parameters, we identified optimal conditions that resulted in a substantial reduction in surface roughness (Ra) by approximately 69%. Moreover, the integration of optimized ironing process parameters led to remarkable improvements in mechanical properties. For instance, the Ultimate Tensile Strength (UTS) saw a substantial improvement of approximately 29%, while the compressive strength (CS) showed an increase of about 25%. The flexural strength (FS) witnessed a notable enhancement of around 35%, and the impact strength (IS) experienced a significant boost of about 162%. The introduction of ironing minimizes voids, enhances layer bonding, and reduces surface irregularities, resulting in components that not only exhibit exceptional mechanical performance but also possess refined aesthetics. This research sheds light on the transformative potential of precision experimentation, post-processing techniques, and statistical methodologies in advancing Material Extrusion technology. The findings offer practical implications for industries requiring high-performance components with structural integrity and aesthetic appeal.
Colorful graphene-based wearable e-textiles prepared by co-dyeing cotton fabrics with natural dyes and reduced graphene oxide
Authors: Moon Sungwoo , Chae Youngjoo 
Published: January 2024

AbstractIn addition to the functionality of electronic textiles (e-textiles), their aesthetic properties should be considered to expand their marketability. In this study, premordanted cotton fabrics were co-dyed with reduced graphene oxide (rGO) and natural dyes to develop ecofriendly and colorful graphene-based wearable e-textiles. The color attributes of the textiles were analyzed in terms of the dyeing conditions, namely, rGO loading, mordant type, and natural dye type. The lightness of the dyed samples increased in the order of cochineal < gardenia blue < rhubarb. Regardless of the natural dye and rGO loading, the lightness of the fabrics mordanted with Fe was lower than that with Al and Cu. Moreover, the rhubarb- and gardenia blue-dyed fabrics exhibited broad chroma and hue dispersions, indicating the strong impact of the dyeing conditions. With increasing rGO loading, the chroma of the rhubarb-dyed fabrics substantially decreased, resulting in decreased color saturation. The initial greenish-blue color of the gardenia blue-dyed fabrics gradually changed to yellowish-green and then yellow. Regardless of the natural dye, drastic overall color changes were observed, with average values of 7.60, 11.14, 12.68, and 13.56 ΔECMC(2:1) at increasing rGO loadings of 1, 3, 5, and 7% owb, respectively.
Temporal elevation of blood pressure is associated with increased risk of sudden cardiac arrest
Authors: Kim Yun Gi , Min Kyongjin , Jeong Joo Hee , Roh Seung-Young , Han Kyung-Do , Shim Jaemin , Choi Jong-Il , Kim Young-Hoon 
Published: January 2024

AbstractHypertension is a known risk factor for sudden cardiac arrest (SCA). However, the role of temporal changes in blood pressure on the risk of SCA is not fully understood. This study was conducted to determine whether a temporal increase or decrease in blood pressure is associated with the risk of SCA. This study was based on nationwide healthcare insurance data. Individuals who underwent nationwide health check-ups in 2009 and 2011 were analyzed. A total of 2,801,153 individuals were evaluated for 8100 SCA events during the 17, 740, 420 person-years of follow-up. In a multivariate analysis, there were linear association between the degree of temporal elevation of systolic blood pressure (SBP) and the risk of SCA: (i) adjusted-hazard ratio (HR) 1.11 (p = 0.001) in 10 ≤ ΔSBP < 20 (mmHg) group; (ii) adjusted-HR 1.40 (p < 0.001) in 20 ≤ ΔSBP < 40 group; and (iii) adjusted-HR 1.88 (p < 0.001) in 40 ≤ ΔSBP group as compared with the reference group (− 10 ≤ ΔSBP < 10). Temporal increase in diastolic blood pressure (DBP) also a showed significant association with SCA risk with the highest risk observed in ∆DBP ≥ 25 group (adjusted-HR 1.61; p < 0.001) as compared with the reference group (− 5 ≤ ΔDBP < 5). The association between SBP and SCA was not affected by age, sex, presence of diabetes mellitus, or baseline SBP. In conclusion, a temporal increase in blood pressure was significantly associated with the occurrence of SCA, and this association was consistent across all subgroups. However, a temporary decrease in blood pressure does not reduce the risk of SCA. Prevention of elevated blood pressure may play an important role in preventing SCA.
Second haploidentical bone marrow transplantation with antithymocyte antibody-containing conditioning regimen for graft failure in eight patients with severe aplastic anemia
Authors: Zhang Chengtao , Hou Yutong , Yang Yan , Zhang Jingjing , Zheng Xiaoli , Yan Jinsong 
Published: January 2024

AbstractThe effects of a second haploidentical bone marrow transplantation with an antithymocyte antibody-containing conditioning regimen after graft failure in patients with severe aplastic anemia remain unclear. Eight severe aplastic anemia patients with graft failure with a median age of 12.5 (range, 3–22) years were retrospectively reviewed. At the second transplantation, they received a median mononuclear cell number of 15.7 (range, 11.2–20.9) × 108/kg or a median CD34+ cell number of 6.2 (range, 2.5–17.5) × 106/kg. They were all successfully engrafted, with a median time of 12.5 (range, 11–16) days for neutrophils and 24 (range, 14–50) days for platelets. Three patients developed skin acute graft-versus-host disease Grades I–II, and another 3 developed limited chronic graft-versus-host disease. All patients successfully recovered after treatment with methylprednisolone (0.5–1 mg/kg/day) and tacrolimus. One patient each died of respiratory failure caused by multidrug-resistant Klebsiella pneumoniae at 8 months and invasive fungal disease at 23 months after transplantation. Six patients survived with a 5-year estimated overall survival of 75% and a median follow-up time of 61 (range, 8–129) months. A second haploidentical bone marrow transplantation with an antithymocyte antibody-containing conditioning regimen was feasible for saving severe aplastic anemia patients with graft failure.
A fragmented neural network ensemble method and its application to image classification
Authors: Zhang Xu , Liu Shuai , Wang Xueli , Li Yumei 
Published: January 2024

AbstractIn recent years, deep neural networks have evolved rapidly in engineering technology, with models becoming larger and deeper. However, for most companies, developing large models is extremely costly and highly risky. Researchers usually focus on the performance of the model, neglecting its cost and accessibility. In fact, most regular business scenarios do not require high-level AI. A simple and inexpensive modeling method for fulfilling certain demands for practical applications of AI is needed. In this paper, a Fragmented neural network method is proposed. Inspired by the random forest algorithm, both the samples and features are randomly sampled on image data. Images are randomly split into smaller pieces. Weak neural networks are trained using these fragmented images, and many weak neural networks are then ensembled to build a strong neural network by voting. In this way, sufficient accuracy is achieved while reducing the complexity and data volume of each base learner, enabling mass production through parallel and distributed computing. By conducting experiments on the MNIST and CIFAR10 datasets, we build a model pool using FNN, CNN, DenseNet, and ResNet as the basic network structure. We find that the accuracy of the ensemble weak network is significantly higher than that of each base learner. Meanwhile, the accuracy of the ensemble network is highly dependent on the performance of each base learner. The accuracy of the ensemble network is comparable to or even exceeds that of the full model and has better robustness. Unlike other similar studies, we do not pursue SOTA models. Instead, we achieved results close to the full model with a smaller number of parameters and amount of data.
Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo)
Authors: Chondrelli Niki , Kuehn Emily , Meurling Sara , Cortázar-Chinarro Maria , Laurila Anssi , Höglund Jacob 
Published: January 2024

AbstractBatrachochytrium dendrobatidis (Bd) is a fungal pathogen that has decimated amphibian populations worldwide for several decades. We examined the changes in gene expression in response to Bd infection in two populations of the common toad, Bufo bufo, in a laboratory experiment. We collected B. bufo eggs in southern and northern Sweden, and infected the laboratory-raised metamorphs with two strains of the global panzoonotic lineage Bd-GPL. Differential expression analysis showed significant differences between infected and control individuals in both liver and skin. The skin samples showed no discernible differences in gene expression between the two strains used, while liver samples were differentiated by strain, with one of the strains eliciting no immune response from infected toads. Immune system genes were overexpressed in skin samples from surviving infected individuals, while in liver samples the pattern was more diffuse. Splitting samples by population revealed a stronger immune response in northern individuals. Differences in transcriptional regulation between populations are particularly relevant to study in Swedish amphibians, which may have experienced varying exposure to Bd. Earlier exposure to this pathogen and subsequent adaptation or selection pressure may contribute to the survival of some populations over others, while standing genetic diversity in different populations may also affect the infection outcome.
The influence of tactical formation on physical and technical performance across playing positions in the Chinese super league
Authors: Zhang Wei , Gong Bo , Tao Rancheng , Zhou Fei , Ruano Miguel Ángel Gómez , Zhou Changjing 
Published: January 2024

AbstractThis study aimed to investigate the impact of tactical formations on the physical and technical performance of professional football players in the Chinese Super League (CSL). A sample of 800 games from the 2015–2021 CSL was analyzed, and players' physical (total distance covered, distance covered while ball in play, number of sprints, sprint distance, and high/middle/low-speed running) and technical (gain/loss of possession, ball retention percentage, challenges, challenge success percentage, passes, and pass success percentage) performance was assessed across six team formations: 3-5-2 (n = 137), 4-3-3 (n = 77), 4-2-3-1 (n = 391), 4-4-2 (n = 257), 3-4-3 (n = 41), and 4-1-4-1 (n = 107). Linear mixed models were used to assess variations in performance indicators across positions and formations. The results demonstrated that central defenders traveled significantly more total and low-speed running distances in the 3-5-2 formation than in the 4-2-3-1 formation (ES range: 0.33–0.34, p < 0.01). Fullbacks in the 3-5-2 formation demonstrated more high-speed running than did those in the 4-4-2 formation (ES = 0.27, p = 0.04). The central midfielders exhibited significantly more sprints and longer sprint distances in the 4-2-3-1 formation than in the 4-4-2 formation (ES range: 0.2–0.24, p < 0.01). Regarding technical performance, central defenders displayed significantly greater ball retention percentages, passes, and pass success rates in the 3-4-3 than in the 3-5-2 formations (ES range: 0.58–0.65, p < 0.01). Moreover, fullbacks and central midfielders executed markedly more passes with superior pass success rates in 4-back formations than in 3-5-2 formations (ES range: 0.2–0.53, p < 0.01). These findings can help coaches and academic staff understand the physical and technical requirements of various positions in various tactical formations, thus optimizing the training process.
Understanding climate change impacts on drought in China over the 21st century: a multi-model assessment from CMIP6
Authors: Xu Feng , Qu Yanping , Bento Virgílio A. , Song Hongquan , Qiu Jianxiu , Qi Junyu , Wan Lingling , Zhang Rongrong , Miao Lijuan , Zhang Xuesong , Wang Qianfeng 
Published: January 2024

AbstractThe future state of drought in China under climate change remains uncertain. This study investigates drought events, focusing on the region of China, using simulations from five global climate models (GCMs) under three Shared Socioeconomic Pathways (SSP1-2.6, SSP3-7.0, and SSP5-8.5) participating in the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP3b). The daily Standardized Precipitation Evapotranspiration Index (SPEI) is employed to analyze drought severity, duration, and frequency over three future periods. Evaluation of the GCMs’ simulations against observational data indicates their effectiveness in capturing historical climatic change across China. The rapid increase in CO2 concentration under high-emission scenarios in the mid- and late-future century (2040–2070 and 2071–2100) substantially influences vegetation behavior via regulation on leaf stomata and canopy structure. This regulation decelerates the increase in potential evapotranspiration, thereby mitigating the sharp rise in future drought occurrences in China. These findings offer valuable insights for policymakers and stakeholders to develop strategies and measures for mitigating and adapting to future drought conditions in China.
Optimal thermodynamic conditions to minimize kinetic by-products in aqueous materials synthesis
Authors: Wang Zheren , Sun Yingzhi , Cruse Kevin , Zeng Yan , Fei Yuxing , Liu Zexuan , Shangguan Junyi , Byeon Young-Woon , Jun KyuJung , He Tanjin , Sun Wenhao , Ceder Gerbrand 
Published: January 2024

AbstractPhase diagrams offer substantial predictive power for materials synthesis by identifying the stability regions of target phases. However, thermodynamic phase diagrams do not offer explicit information regarding the kinetic competitiveness of undesired by-product phases. Here we propose a quantitative and computable thermodynamic metric to identify synthesis conditions under which the propensity to form kinetically competing by-products is minimized. We hypothesize that thermodynamic competition is minimized when the difference in free energy between a target phase and the minimal energy of all other competing phases is maximized. We validate this hypothesis for aqueous materials synthesis through two empirical approaches: first, by analysing 331 aqueous synthesis recipes text-mined from the literature; and second, by systematic experimental synthesis of LiIn(IO3)4 and LiFePO4 across a wide range of aqueous electrochemical conditions. Our results show that even for synthesis conditions that are within the stability region of a thermodynamic Pourbaix diagram, phase-pure synthesis occurs only when thermodynamic competition with undesired phases is minimized.
Second International Conference and Workshop on Interventional Radiology 2023, Dhaka, Bangladesh: Advancements, Achievements, and Challenges
Authors: Datta Anindita , Bhowmik Bishwajit , Alam Syed Zoherul , Islam Md Tariqul , Sultana Syeda Naheed 
Published: January 2024

AbstractInterventional radiology, which combines diagnostic and therapeutic approaches to address and treat a variety of medical diseases, has emerged as an expeditiously developing area at the confluence of radiology and minimally invasive procedures. The authors provide a general overview of the Bangladesh Society of Vascular and Interventional Radiology (BSVIR), including its goals, contributions, and effect on the Bangladeshi healthcare sector. The second interventional radiology conference was held in Dhaka and was organized by the Bangladesh Society of Radiology and Imaging, and BSVIR, in alliance with the Indian Society of Vascular and Interventional Radiology. This allowed the exchange of ideas and innovations as well as a discussion of recent advances in this dynamic field. This manuscript also highlights the key points, emerging trends, and scientific sessions that were presented at the conference.
Reporting of Participants' Sex, Race, Ethnicity, and Socioeconomic Status in Pituitary Surgery Literature
Authors: Nourmahnad Anahita , Purrinos Julian A. , Grozovsky Renata , Richardson Angela M. , Levine Corinna G. 
Published: January 2024

Abstract
Introduction Social determinants of health (SDOH) are associated with differential outcomes after pituitary tumor treatment. However, the specific impact of SDOH is not well characterized. One reason may be the lack of collection and reporting of sociodemographic variables in the literature. This study aims to evaluate the frequency of reporting and distribution of participants' sex, race, ethnicity, income, and education level within pituitary surgery literature. We will compare the reported clinical research population demographics to the 2020 U.S. census.
Methods A systematic review was performed by searching PubMed, Cochrane, and Embase databases for pituitary surgery clinical research published between July 1, 2021 to June 30, 2022. We excluded studies that lacked a comparison group, were not original research (i.e., systematic reviews, meta-analysis), or included national databases and registry data.
Results The final analysis included 92 studies. A total of 99% of studies collected data on subject sex. On average 49% (range: 14–100%) of study populations were male. Only 4% (n = 4) studies included racial demographic data. Two studies included information on participants' ethnicity and two included education background. No studies included income or insurance data. Four U.S. studies included demographic distribution, and the reported race and ethnicity percentages are similar to the U.S. 2020 census distribution.
Conclusion Most clinical pituitary research collects and reports data on participant sex. However, very few studies collect and report data on other sociodemographic variables that can play a role in outcomes. The lack of sociodemographic information in clinical research literature makes it difficult to determine the role of SDOH on pituitary surgery outcomes.
Brainwave implanted reservoir computing
Authors: Chen Li-Yu , Chen Yi-Chun , Huang Jason C. , Sok Sophie , Armbruster Vincent , Chen Chii-Chang 
Published: January 2024

This work aims to build a reservoir computing system to recognize signals with the help of brainwaves as the input signals. The brainwave signals were acquired as the participants were listening to the signals. The human brain in this study can be regarded as the assistant neural networks or non-linear activation function to improve the signal recognition. We showed that within the brainwave frequency ranges from 14 to 16, 20, 30, and 32 Hz, the mean squared errors of the input signal recognition were lower than those without brainwaves. This result has demonstrated that the reservoir computing system with the help of human responses can obtain more precise results.