bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which factors drive the choice of the French‐speaking Quebec population towards a COVID‐19 vaccination programme: A discrete‐choice experiment
Authors: Morillon Gabin F. , Poder Thomas G. 
Published: January 2024

AbstractObjectivesThe aims of this study were to elicit preferences about the coronavirus disease 2019 (COVID‐19) vaccine campaign in the general French‐speaking adult Quebec population and to highlight the characteristics of the vaccine campaign that were of major importance.MethodsA discrete‐choice experiment (DCE) was conducted between April and June 2021, in Quebec, Canada. A quota sampling method by age, gender and educational level was used to achieve a representative sample of the French‐speaking adult population. The choice‐based exercise was described by seven attributes within a vaccine campaign scenario. A mixed logit (MXL) model and a latent class logit (LCL) model were used to derive utility values. Age, gender, educational level, income and fear of COVID‐19 were included as independent variables in the LCL.ResultsA total of 1883 respondents were included for analysis, yielding 22,586 choices. From these choices, 3425 (15.16%) were refusals. In addition, 1159 (61.55%) individuals always accepted any of the vaccination campaigns, while 92 individuals (4.89%) always refused vaccine alternatives. According to the MXL, relative weight importance of attributes was effectiveness (32.50%), risk of side effects (24.76%), level of scientific evidence (22.51%), number of shots (15.73%), priority population (3.60%), type of vaccine (0.61%), and vaccination location (0.28%). Four classes were derived from the LCL model and attributes were more or less important according to them. Class 1 (19.8%) was more concerned about the effectiveness (27.99%), safety (24.22%) and the number of shots (21.82%), class 2 (55.3%) wanted a highly effective vaccine (40.16%) and class 3 (17.6%) gave high value to the scientific evidence (42.00%). Class 4 preferences (7.4%) were more balanced, with each attribute having a relative weight ranging from 1.84% (type of vaccine) to 21.32% (risk of side effects). Membership posterior probabilities to latent classes were found to be predicted by individual factors such as gender, annual income or fear of COVID‐19.ConclusionsVaccination acceptance relies on multiple factors. This study allowed assessment of vaccination‐specific issues through a choice‐based exercise and description of factors influencing this choice by segmenting the sample and drawing profiles of individuals. Moreover, besides effectiveness and safety, a major point of this study was to show the importance given by the general population to the level of scientific evidence surrounding vaccines.Patient or Public ContributionA small group of citizens was involved in the conception, design and interpretation of data. Participants of the DCE were all from the general population.
Older versus younger patients in robot‐assisted radical cystectomy with intracorporeal ileal conduit comparing safety and clinical outcomes
Authors: Sowanthip Dutsadee , Zennami Kenji , Bejrananda Tanan , Nukaya Takuhisa , Takenaka Masashi , Ichino Manabu , Takahara Kiyoshi , Sasaki Hitomi , Kusaka Mamoru , Sumitomo Makoto , Shiroki Ryoichi 
Published: January 2024

ObjectiveTo evaluate the safety and efficacy of robot‐assisted radical cystectomy using an intracorporeal ileal conduit in older compared to younger patients.MethodsWe retrospectively analyzed 122 patients who underwent robot‐assisted radical cystectomy with an intracorporeal ileal conduit at Fujita Health University Hospital and Fujita Health University Okazaki Medical Center between 2012 and 2022. Patients were categorized into two groups: older (age ≥ 75 years; n = 53) and younger (age < 75 years; n = 69). Perioperative outcomes, complications, recurrence‐free survival, cancer‐specific survival, and overall survival were compared between the cohorts.ResultsThe groups had no significant differences in perioperative outcomes, such as estimated blood loss, operative time, and blood transfusion rate. However, hospital stay was longer in the older patients than in the younger group (19 vs. 16 days; p < 0.001). The 30‐day minor and major complication rates were 33.3% and 13.0%, respectively, for the younger group and 50.9% and 9.4% for the older group (p = 0.11). Urinary tract infection and bowel ileus were the most common complications in both groups. No significant differences were observed in recurrence‐free survival, cancer‐specific survival, and overall survival between the groups (p = 0.58, p = 0.75, and p = 0.78), and subgroup analysis in ≥cT3 revealed the older group tended to have poorer cancer‐specific survival and overall survival (p = 0.07 and p = 0.01). Multivariate analysis indicated that older age was not associated with high‐grade complications and cancer‐specific survival.ConclusionsRobot‐assisted radical cystectomy with an intracorporeal ileal conduit is a safe and effective treatment option for older patients.
Calcium–magnesium–aluminum‐silicate melt viscosities influenced by lanthanides, yttrium, and zirconium
Authors: Müller Dirk , Dingwell Donald B. 
Published: January 2024

AbstractLanthanides (Ln2O3) and elements like Zr and Y find application in the highest temperature‐resistant thermal and/or environmental barrier coatings. Such coatings are routinely exposed to silicate particles (e.g., sand, dust, volcanic ash), leading to chemical reactions that degrade the coating. The dissolution of 13.5 wt.% Ln2O3 into a calcium–magnesium–aluminum‐silicate (CMAS) melt leads to a viscosity reduction for the light lanthanides, while viscosity increases toward heavier lanthanides. For Gd, Y, and Zr, various amounts up to 13.5 wt.% (Gd2O3, Y2O3, ZrO2) were added to the CMAS melt, showing a tendency of increased viscosity for low concentrations (2.5‐3 wt.%) and a decreasing viscosity for higher values of the added component.
Accessibility and feasibility of experience sampling methods for mental health research with people with intellectual disability: Scoping of research and stakeholder views
Authors: Bakkum Lianne , Paalman Célinde , Müller Annelieke , van Eeghen Agnies , Schuengel Carlo 
Published: January 2024

AbstractBackgroundExperience sampling may be useful for mental health research with people with intellectual disability, and evidence of the potential benefits is starting to emerge. This multiple‐method study identified potential avenues for tailoring this method to the needs of people with intellectual disability.MethodA scoping review was conducted. Five databases were searched for experience sampling studies involving people with intellectual disability. In addition, seven adults with an intellectual disability tested experience sampling apps with standardised questions about mental health and were interviewed about their experiences in semi‐structured interviews.ResultsSeven studies were included in the scoping review. Two studies investigated acceptability and feasibility. In the interviews, participants reported on the acceptability, availability, and appropriateness of experience sampling applications.ConclusionsThere are still important gaps in knowledge about acceptability, availability, and appropriateness of experience sampling for this population. Researchers are recommended to tailor experience sampling applications to the needs and interests of individual users.
Modeling non‐isothermal pathogen inactivation during liquid foods processing by pulsed light technology
Authors: Pihen Christelle , Mani‐López Emma , López‐Malo Aurelio , Ramírez‐Corona Nelly 
Published: January 2024

AbstractPulsed light (PL) technology has received significant attention as a sustainable alternative for food processing. PL involves a photochemical and photothermal mechanism for microbial inactivation. However, the simultaneous description of both effects to evaluate the technology's efficiency remains unexplored. Furthermore, the process efficiency strongly depends on the optical properties of treated food products. This work evaluated the performance of a non‐isothermal model, previously reported in the literature for different emergent technologies, compared to the conventional Weibull model to describe the inactivation of Escherichia coli ATTC 25922 and Listeria monocytogenes Scott A by pulsed light (from 0 to 300 J/cm2) inoculated in the tested systems. Five food products and two model solutions with different optical characteristics were treated, and their optical properties were correlated to both microbial inactivation and temperature increase, resulting from the photothermal effect. The non‐isothermal mathematical model effectively captures both aspects within the PL mechanism. The inclusion of ascorbic acid in the analyzed samples significantly (p < 0.05) reduced the efficiency of microbial inactivation.Practical applicationsUsing pulsed light technology in food processing is a remarkable innovation that harnesses the potential to amplify and optimize natural resources while reducing energy consumption and time processing. This approach harnesses the controlled application of short, intense light bursts to perform various tasks such as preservation, disinfection, and decontamination. By effectively targeting and inactivating harmful microorganisms, pulsed light avoids the need for excessive chemical treatments or prolonged exposure to high temperatures, thus preserving the innate nutritional value, flavor, and texture of food products. This method avoids the generation of hazardous by‐products or excess waste, aligning perfectly with sustainable practices.
The role of nursing care continuity report in predicting length of hospital stay in older people: A retrospective cohort study
Authors: Montero‐Marco Jesica , Charlo‐Bernardos Marta , Subirón‐Valera Ana Belén , Erickson Hunter , Herrero‐Cortina Beatriz , Altarribas‐Bolsa Elena 
Published: January 2024

AbstractBackgroundThe Nursing Care Continuity Report (NCCR) is a tool for evaluating the quality of nursing care during hospital admission.AimTo explore the role of the NCCR in predicting longer length of stay (LOS) in older adults (≥65 years) admitted to a tertiary hospital and determine possible clinical differences at discharge between patients who had a short LOS (≤7 days) and a prolonged LOS (>7 days).Research Design and SettingA retrospective cohort study was conducted including all patients with a completed NCCR admitted to the hospital between 2015 and 2019. Sociodemographic data, risk of pressure injuries, level of dependence, presence and intensity of pain, and presence and type of pressure injury were the variables registered in the NCCR.ResultsA total of 41,354 patients were included in this study, with a mean age of 78 years, of whom 47% were female. At admission, 21% of patients were at potential risk of developing pressure ulcers. Age, admission to the internal or respiratory medicine unit, and having at least medium risk of developing pressure ulcers were the predictors of prolonged LOS using a random sample of 950 patients. At discharge, patients with prolonged LOS presented higher risk of pressure ulcers and a higher level of dependency and were more likely to present hospital‐acquired pressure ulcers.ConclusionsOlder adults from the internal or respiratory medicine unit who exhibited higher risk of pressure ulcers were related to a prolonged LOS, a higher level of dependency, and hospital‐acquired ulcers at hospital discharge.Relevance to Clinical PracticeIdentifying clinical data that have a greater relationship with LOS could be a useful tool for nursing management and for the implementation of strategies to prevent adverse events during hospitalisation.No Patient or Public ContributionNo direct patient contact was made during the data collection.
Patient competence in chronic illness: A concept derivation
Authors: Crowder Vivian , Brady Veronica , Johnson Constance , Whisenant Meagan 
Published: January 2024

AbstractAims and ObjectivesThis paper aims to inform nursing and other healthcare disciplines by clearly defining patient competence and the skills required to improve self‐care behaviours.BackgroundCompetence has been defined in education and leadership. However, competence in persons with chronic disease has not been expanded upon since one publication in 1983. Patient competence needs to be developed and defined so that healthcare disciplines can understand the attributes necessary for a patient to be deemed competent to promote self‐care behaviours.DesignA concept derivation.MethodsWalker and Avant's approach to concept derivation was used to identify a base concept (competence) that is well‐defined in another field, define the concepts associated with the parent field, and transpose that definition to a new field to formulate a redefined concept. PsycINFO, Scopus, Web of Science and Medline were searched, and 21 articles were included.ResultsPatient competence is defined as the ability of a person with a chronic illness to reach skill mastery, achieve knowledge, maintain a positive attitude and develop trust in themselves and in healthcare providers that will facilitate active engagement to improve self‐care behaviours.ConclusionsDefining patient competence is important in assisting nurses and other healthcare providers in understanding the attributes needed to deem a patient competent, especially those living with chronic illnesses requiring lifelong self‐care behaviours. More research is needed to aid in the designing of a precise instrument for measuring this phenomenon.Relevance to Clinical PracticeConcept derivation of patient competence provides a framework for nurses and other members of the healthcare profession to understand the attributes needed to determine patient competence.
Precision medicine using whole genome sequencing identifies a novel dystrophin (DMD) variant for X‐linked muscular dystrophy in a cat
Authors: Shelton G. Diane , Tucciarone Fabrizio , Guo Ling T. , Coghill Lyndon M. , Lyons Leslie A. 
Published: January 2024

AbstractBackgroundMuscular dystrophies (MDs) are a large, heterogeneous group of degenerative muscle diseases. X‐linked dystrophin‐deficient MD in cats is the first genetically characterized cat model for a human disease and a few novel forms have been identified.Hypothesis/ObjectivesMuscular dystrophy was suspected in a young male domestic shorthair cat. Clinical, molecular, and genetic techniques could provide a definitive diagnosis.AnimalsA 1‐year‐old male domestic shorthair cat presented for progressive difficulty walking, macroglossia and dysphagia beginning at 6 months of age. The tongue was thickened, protruded with constant ptyalism, and thickening and rigidity of the neck and shoulders were observed.MethodsA complete neurological examination, baseline laboratory evaluation and biopsies of the trapezius muscle were performed with owner consent. Indirect immunofluorescence staining of muscle cryosections was performed using several monoclonal and polyclonal antibodies against dystrophy‐associated proteins. DNA was isolated for genomic analyses by whole genome sequencing and comparison to DNA variants in the 99 Lives Cat Genome Sequencing dataset.Results and Clinical ImportanceAspartate aminotransferase (687 IU/L) and creatine kinase (24 830 IU/L) activities were increased and mild hypokalemia (3.7 mmol/L) was present. Biopsy samples from the trapezius muscle confirmed a degenerative and regenerative myopathy and protein alterations identified by immunohistochemistry resulted in a diagnosis of a in dystrophin‐deficient form of X‐linked MD. A stop gain variant (c.4849C>T; p.Gln1617Ter) dystrophin was identified by genome sequencing. Precision/genomic medicine efforts for the domestic cat and in veterinary medicine support disease variant and animal model discovery and provide opportunities for targeted treatments for companion animals.
Spatiotemporal variation in clam recruitment among beaches in Washington State (USA)
Authors: Kobelt J. N. , Yiu D. S. , Dethier M. N. , Ruesink J. L. 
Published: January 2024

AbstractAbundant clam populations provide ecosystem services and commercial and recreational shellfish harvests worldwide. Two non‐native clams (Manila clams, Ruditapes philippinarum; eastern soft‐shell clams, Mya arenaria) commonly populate mid‐intertidal zones of coarse‐sediment beaches in Washington State, USA. To better understand factors influencing their abundance, we used passive mid‐intertidal spat collectors to determine the density and distribution of clam recruits (150–500 μm shell length) at eight beaches spanning over 500 km and over two reproductive seasons (2016 and 2017). Cumulative seasonal recruitment (clams <500 μm) in 2016 and 2017 at +1.0 m MLLW ranged from 800 to 125,000 m−2 for Ruditapes philippinarum and 50–85,000 m−2 for M. arenaria, and did not differ by substrate type at small scales (gravel vs. crushed shell). At larger scales, different interannual recruitment patterns across sites did not dramatically shift the ranked order of highest and lowest recruitment sites. Cumulative recruitment tended to be lower at warmer sites, while timing of peak recruitment was not consistently related to temperature. Sites also differed in the relative recruitment of the two clam species, but most beaches had greater densities of R. philippinarum than M. arenaria at both recruitment and juvenile stages. Although recruitment densities differed by two orders of magnitude across sites, post‐settlement factors eliminated initial spatial variation within a year, dampening recruitment variability among these beaches that all contribute to commercial and recreational clam production.
Identifying and understanding barriers to optimal complementary feeding in Kenya
Authors: Kamudoni Penjani , Kiige Laura , Ortenzi Flaminia , Beal Ty , Nordhagen Stella , Kirogo Veronica , Arimi Caroline , Zvandaziva Charity , Garg Aashima , Codjia Patrick , Rudert Christiane 
Published: January 2024

AbstractOptimal complementary feeding between the ages of 6 and 23 months provides children with the required range of nutritious and safe foods while continuing to be breastfed to meet their needs for essential nutrients and develop their full physical and cognitive potential. The rates of exclusive breastfeeding in the first 6 months of life have increased from 32% in 2008 to 60% in 2022 in Kenya. However, the proportion of children between 6 and 23 months receiving a minimum acceptable diet remains low and has declined from 39% in 2008 to 31% in 2023. The Kenyan Ministry of Health, GAIN and UNICEF collaborated to understand the drivers of complementary feeding practices, particularly proximal determinants, which can be directly addressed and acted upon. A secondary analysis of household surveys and food composition data was conducted to outline children's dietary patterns within the different regions of Kenya and the extent to which the affordability of animal‐source foods could be improved. Ethnographic data were analyzed to identify socio‐cultural barriers to optimal complementary feeding. Furthermore, we outlined the critical steps for developing user‐friendly and low‐cost complementary feeding recipes. The results of all the analyses are presented in five of the six papers of this Special Issue with this additional paper introducing the Kenyan context and some of the critical findings. The Special Issue has highlighted multidimensional barriers surrounding the use and availability of animal‐source foods. Furthermore, it emphasizes the need for a multi‐sectoral approach in enacting policies and programmes that address these barriers.
Phased genome assemblies reveal haplotype‐specific genetic load in the critically endangered Chinese Bahaba (Teleostei, Sciaenidae)
Authors: Cui Rongfeng , Wu Jinxian , Yan Kuoqiu , Luo Sujun , Hu Yuting , Feng Wei , Lu Bingqian , Wang Junjie 
Published: January 2024

AbstractWhile haplotype‐specific genetic load shapes the evolutionary trajectory of natural and captive populations, mixed‐haplotype assembly and genotyping hindered its characterization in diploids. Herein, we produced two phased genome assemblies of the critically endangered fish Chinese Bahaba (Bahaba taipingensis, Sciaenidae, Teleostei) and resequenced 20 whole genomes to quantify population genetic load at a haplotype level. We identified frame‐shifting variants as the most deleterious type, followed by mutations in the 5′‐UTR, 3′‐UTR and missense mutations at conserved amino acids. Phased haplotypes revealed gene deletions and high‐impact deleterious variants. We estimated ~1.12% of genes missing or interrupted per haplotype, with a significant overlap of disrupted genes (30.35%) between haplotype sets. Relative proportions of deleterious variant categories differed significantly between haplotypes. Simulations suggested that purifying selection struggled to purge slightly deleterious genetic load in captive breeding compared to genotyping interventions, and that higher inter‐haplotypic variance of genetic load predicted more efficient purging by artificial selection. Combining the knowledge of haplotype‐resolved genetic load with predictive modelling will be immensely useful for understanding the evolution of deleterious variants and guiding conservation planning.
Deconstructing spiritual care: Discursive underpinnings within palliative care research
Authors: Lundberg Emma , Öhlén Joakim , Dellenborg Lisen , Ozanne Anneli , Enstedt Daniel 
Published: January 2024

AbstractReligion and spirituality are integral to the philosophy of palliative care, shaping its approach to spiritual care. This article aims to examine the discourses within palliative care research to illuminate prevailing assumptions regarding spiritual care. Eighteen original articles were analyzed to examine how spiritual care is understood within palliative care. The analysis, informed by Foucault, aimed to identify recurring discourses. The finding reveals that, in palliative care research, spirituality is viewed as enigmatic yet inherently human and natural, assuming that every individual has a spiritual dimension. The analysis points to healthcare professionals being expected to hold certain qualities to put spiritual care into practice. The analysis also reveals that in the analyzed articles, the concept of spiritual care is rooted in a Christian context, with the belief that all individuals possess inherent spirituality or religiosity, a concept often associated with Christian theology. The included articles often utilize theological terms and emphasize a monotheistic viewpoint. Spirituality is articulated as a complex, distinct concept, challenging clear definitions and professional responsibilities. Further, a moral formation of healthcare professionals is described, interpelling and ascribing qualities that healthcare professionals need to provide spiritual care.
Haploid rhapsody: the molecular and cellular orchestra of in vivo haploid induction in plants
Authors: Quiroz Luis Felipe , Gondalia Nikita , Brychkova Galina , McKeown Peter C. , Spillane Charles 
Published: January 2024

SummaryIn planta haploid induction (HI), which reduces the chromosome number in the progeny after fertilization, has garnered increasing attention for its significant potential in crop breeding and genetic research. Despite the identification of several natural and synthetic HI systems in different plant species, the molecular and cellular mechanisms underlying these HI systems remain largely unknown. This review synthesizes the current understanding of HI systems in plants (with a focus on genes and molecular mechanisms involved), including the molecular and cellular interactions which orchestrate the HI process. As most HI systems can function across taxonomic boundaries, we particularly discuss the evidence for conserved mechanisms underlying the process. These include mechanisms involved in preserving chromosomal integrity, centromere function, gamete communication and/or fusion, and maintenance of karyogamy. While significant discoveries and advances on haploid inducer systems have arisen over the past decades, we underscore gaps in understanding and deliberate on directions for further research for a more comprehensive understanding of in vivo HI processes in plants.