bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavioral factors influencing the acceptance and usage of waste bins in Ghana: application of the extended theory of planned behavior (TPB)
Authors: Boakye Maxwell Kwame , Adanu Selase Kofi , Agbosu Worlanyo Kwabena , Lissah Samuel Yaw , Abdul-Aziz Abdul-Rahaman , Owusu Anita Gyamea 
Published: January 2024

PurposeSeveral waste bin sanitation initiatives have been introduced in Ghana to address the surge in indiscriminate solid waste disposal in households. What is not known are the behavior factors that determine the acceptability and use of waste bins. This study aimed to identify the determinants of waste bin acceptability and use in Ghana using the theory of planned behavior (TPB).Design/methodology/approachData on waste bin acceptability and usage were collected from 881 households in the Volta and Oti regions of Ghana. The data were analyzed using the partial least squares-structural equation modeling technique in SmartPLS 3 software.FindingsThe coefficient of determination (R-squared value) of the original TPB and the extended model explained 39.9 and 44.7% of the variance in waste bin acceptability and use intentions, respectively. The results revealed that attitudes (ß = 0.114, t = 3.322, p < 0.001), subjective norms (ß = 0.306, t = 6.979, p < 0.001) and perceived moral obligation (ß = 0.352, t = 8.062, p < 0.001) significantly predicted household waste bin acceptability and use behavior intentions, but perceived behavioral control (ß = −0.003, t = 0.064, p < 0.949) did not influence behavior intentions significantly.Practical implicationsThe study provides valuable insights into the behavioral factors to be prioritized by waste management service providers to improve household waste bin acceptability and usage.Originality/valueThis is one of Ghana's first studies investigating the behavioral determinants of waste bin acceptability and usage.
Dépenses militaires et croissance économique dans l'UEMOA: une analyse des effets de seuil et des canaux de transmission
Authors: Bayale Nimonka , Gado Babatunde Mohamed Sanny , Sambieni Niim‐Bénoua Nahum , Tchala Komla Kuma Esobiyu 
Published: January 2024

RésuméCet article détermine, à travers une approche non linéaire, le seuil de dépenses militaires compatible avec l'objectif de croissance économique. En appliquant un modèle de seuil endogène sur les données en panel des huit pays membres de l'UEMOA, sur la période 1995–2019, les estimations mettent en évidence l'existence d'un seuil de dépenses militaires estimé à 2,48% du PIB dans l'Union. Elles indiquent également que lorsque les dépenses militaires sont à un niveau inférieur à ce seuil, leur effet sur la croissance des États de l'Union est positif et significatif. En revanche, les valeurs supérieures à ce seuil n'apparaissent pas favorables à la croissance économique dans l'UEMOA. En outre, l'étude a identifié deux principaux canaux de transmission des dépenses militaires à la croissance économique dans ces pays, à savoir le capital humain et la stabilité politique. A cet égard, les pays de l'UEMOA devraient limiter les dépenses de défense et de sécurité à 2,48% du PIB au maximum, sauf si le niveau de l'insécurité justifie le dépassement de ce seuil.
Toward a Climate‐Ready Health Care System: Institutional Motivators and Workforce Engagement
Authors: DRESSER CALEB , JOHNS ZACHARY , PALARDY AVERY , McKINNON SARAH , BREAKEY SUELLEN , ROS ANA M. VIAMONTE , NICHOLAS PATRICE K 
Published: January 2024

Policy Points
The US health care system faces mounting pressure to reduce greenhouse gas emissions and adapt to the impacts of climate change; motivated institutions and an engaged health care workforce are essential to the development, implementation, and maintenance of a climate‐ready US health care system.
Health care workers have numerous profession‐specific and role‐specific opportunities to address the causes and impacts of climate change.
Policies must address institutional barriers to change and create incentives aligned with climate readiness goals.
Institutions and individuals can support climate readiness by integrating content on the health care implications of climate change into educational curricula.
Lithium use and bone health in women with bipolar disorder: A cross‐sectional study
Authors: Williams Lana J. , Agustini Bruno , Stuart Amanda L. , Pasco Julie A. , Hodge Jason M. , Samarasinghe Rasika M. , Bjerkeset Ottar , Quirk Shae E. , Koivumaa‐Honkanen Heli , Honkanen Risto , Heikkinen Jeremi , Berk Michael 
Published: January 2024

AbstractIntroductionSeveral psychiatric disorders and medications used to treat them appear to be independently associated with skeletal deficits. As there is increasing evidence that lithium possesses skeletal protective properties, we aimed to investigate the association between lithium use and bone health in a group of women with bipolar disorder.MethodWomen with bipolar disorder (n = 117, 20+ years) were recruited from south‐eastern Australia. Bipolar disorder was confirmed using a clinical interview (SCID‐I/NP). Bone mineral density (BMD; g/cm2) was measured at the spine, hip and total body using dual‐energy x‐ray absorptiometry and low bone mass determined by BMD T‐score of <−1.0. Weight and height were measured, socioeconomic status (SES) determined and information on medication use and lifestyle factors self‐reported. Linear and logistic regression were used to test associations between lithium and (i) BMD and (ii) low bone mass, respectively.ResultsThirty‐five (29.9%) women reported current lithium use. Lithium users and non‐users differed in regard to SES and BMD; otherwise, groups were similar. After adjustments, mean BMD among lithium users was 5.1% greater at the spine (1.275 [95% CI 1.229–1.321] vs. 1.214 [1.183–1.244] g/cm2, p = 0.03), 4.2% greater at the total hip (0.979 [0.942–1.016] vs. 0.938 [0.910–0.966] g/cm2, p = 0.03) and 2.2% greater at the total body (1.176 [1.148–1.205] vs. 1.150 [1.129–1.171] g/cm2, p = 0.08) compared to participants not receiving lithium. Lithium users were also less likely to have low bone mass (22.9% vs. 43.9%, p = 0.031). Associations persisted after adjustment for confounders.ConclusionThese data suggest lithium is associated with greater BMD and reduced risk of low bone mass in women with bipolar disorder. Research into the underlying mechanisms is warranted.
Human social enrichment is linked with reduced mortality in artificially reared ewe lambs
Authors: Cowie Sarah 
Published: January 2024

AbstractGrowth of lambs in an artificial rearing system is key to the economic success of sheep‐milking farms. Social enrichment in the form of quiet human contact has been shown to increase growth rates of lambs after weaning, perhaps by reducing stress and enhancing immune function. One hundred fourteen artificially reared dairy ewe lambs were assigned either to a Social condition receiving quiet human company in three 20‐min segments per day, or a Control condition without quiet human contact. Feeding and housing conditions were otherwise identical. Starting weights for the Social (M = 6.29 kg; SD = 1.19 kg) and Control (M = 6.38 kg; SD = 0.93 kg) lambs were the same, as were their weights after 3 weeks (Mcontrol = 8.89 kg, SD = 2.55 kg, Msocial = 8.63 kg, SD = 2.16 kg). Mortality rates were significantly lower (p = 0.041) in the Social condition (0%) than Control (8%). Thus, social enrichment may be important for the wellbeing of lambs and for economic viability in lamb‐rearing.
Preparing for colorectal surgery: a feasibility study of a novel web‐based multimodal prehabilitation programme in Western Canada
Authors: Ip Nathanael , Zhang Kexin , Karimuddin Ahmer A. , Brown Carl J. , Campbell Kristin L. , Puyat Joseph H. , Sutherland Jason M. , Conklin Annalijn I. 
Published: January 2024

AbstractAimPrehabilitation for colorectal cancer has focused on exercise‐based interventions that are typically designed by clinicians; however, no research has yet been patient‐oriented. The aim of this feasibility study was to test a web‐based multimodal prehabilitation intervention (known as PREP prehab) consisting of four components (physical activity, diet, smoking cessation, psychological support) co‐designed with five patient partners.MethodA longitudinal, two‐armed (website without or with coaching support) feasibility study of 33 patients scheduled for colorectal surgery 2 weeks or more from consent (January–September 2021) in the province of British Columbia, Canada. Descriptive statistics analysed a health‐related quality of life questionnaire (EQ5D‐5L) at baseline (n = 25) and 3 months postsurgery (n = 21), and a follow‐up patient satisfaction survey to determine the acceptability, practicality, demand for and potential efficacy in improving overall health.ResultsPatients had a mean age of 52 years (SD 14 years), 52% were female and they had a mean body mass index of 25 kg m−2 (SD 3.8 kg m−2). Only six patients received a Subjective Global Assessment for being at risk for malnutrition, with three classified as ‘severely/moderately’ malnourished. The majority (86%) of patients intended to use the prehabilitation website, and nearly three‐quarters (71%) visited the website while waiting for surgery. The majority (76%) reported that information, tools and resources provided appropriate support, and 76% indicated they would recommend the PREP prehab programme. About three‐quarters (76%) reported setting goals for lifestyle modification: 86% set healthy eating goals, 81% aimed to stay active and 57% sought to reduce stress once a week or more. No patients contacted the team to obtain health coaching, despite broad interest (71%) in receiving active support and 14% reporting they received ‘active support’.ConclusionThis web‐based multimodal prehabilitation programme was acceptable, practical and well‐received by all colorectal surgery patients who viewed the patient‐oriented multimodal website. The feasibility of providing active health coaching support requires further investigation.
Emulative envy and loving admiration
Authors: Brunning Luke 
Published: January 2024

AbstractWould you rather your friends, family, and partners envy you, or admire you, when you flourish? Many people would prefer to be admired, and so we often strive to tame our envy. Recently, however, Sara Protasi offered an intriguing defence of “emulative envy” which apparently improves us and our relationships, and is compatible with love. I find her account unconvincing, and defend loving admiration in this article. In Section 2, I summarize Protasi's nuanced account of envy. In Section 2, I argue that irrespective of how we analyze emotions in general we can argue that it is preferable to prioritize the cultivation of some emotions over others. In Section 4, I challenge Protasi's assumptions about the affinity between love and envy. My core argument is in Section 5 where I examine envy's impact on the envier, the envied, and relationships. Envy impedes an authentic relationship to the goods and goals in the envier's life, alienates the envied, and stifles joint‐action. From all perspectives admiration typically fares better. After briefly considering the objection that admiration may impede love in Section 6, I conclude, in section seven, that admiration should be preferred to emulative envy in our intimate relationships.
KCTD7‐related progressive myoclonic epilepsy: Report of 42 cases and review of literature
Authors: Yoganathan Sangeetha , Whitney Robyn , Thomas Maya , Danda Sumita , Chettali Akbar Mohamed , Prasad Asuri N. , Farhan Sali M. K. , AlSowat Daad , Abukhaled Musaad , Aldhalaan Hesham , Gowda Vykuntaraju K. , Kinhal Uddhava V. , Bylappa Arun Y. , Konanki Ramesh , Lingappa Lokesh , Parchuri Bindu Madhavi , Appendino Juan P. , Scantlebury Morris H. , Cunningham Jessie , Hadjinicolaou Aristides , El Achkar Christelle Moufawad , Kamate Mahesh , Menon Ramshekhar N. , Jose Manna , Riordan Gillian , Kannan Lakshminarayanan , Jain Vivek , Manokaran Ranjith Kumar , Chau Vann , Donner Elizabeth J. , Costain Gregory , Minassian Berge A. , Jain Puneet 
Published: January 2024

AbstractObjectiveKCTD7‐related progressive myoclonic epilepsy (PME) is a rare autosomal‐recessive disorder. This study aimed to describe the clinical details and genetic variants in a large international cohort.MethodsFamilies with molecularly confirmed diagnoses of KCTD7‐related PME were identified through international collaboration. Furthermore, a systematic review was done to identify previously reported cases. Salient demographic, epilepsy, treatment, genetic testing, electroencephalographic (EEG), and imaging‐related variables were collected and summarized.ResultsForty‐two patients (36 families) were included. The median age at first seizure was 14 months (interquartile range = 11.75–22.5). Myoclonic seizures were frequently the first seizure type noted (n = 18, 43.9%). EEG and brain magnetic resonance imaging findings were variable. Many patients exhibited delayed development with subsequent progressive regression (n = 16, 38.1%). Twenty‐one cases with genetic testing available (55%) had previously reported variants in KCTD7, and 17 cases (45%) had novel variants in KCTD7 gene. Six patients died in the cohort (age range = 1.5–21 years). The systematic review identified 23 eligible studies and further identified 59 previously reported cases of KCTD7‐related disorders from the literature. The phenotype for the majority of the reported cases was consistent with a PME (n = 52, 88%). Other reported phenotypes in the literature included opsoclonus myoclonus ataxia syndrome (n = 2), myoclonus dystonia (n = 2), and neuronal ceroid lipofuscinosis (n = 3). Eight published cases died over time (14%, age range = 3–18 years).SignificanceThis study cohort and systematic review consolidated the phenotypic spectrum and natural history of KCTD7‐related disorders. Early onset drug‐resistant epilepsy, relentless neuroregression, and severe neurological sequalae were common. Better understanding of the natural history may help future clinical trials.
An augmented fuzzy decision support system to analyse compatible cosmetic face masks for various complexions
Authors: Brainy Joseph Raj Vikilal Joice , Narayanamoorthy Samayan , Kalaiselvan Samayan , Saraswathy Ranganathan , Ahmadian Ali , Senu Norazak , Jeon Jeonghwan 
Published: January 2024

AbstractBeauty face masks (BFM) are becoming increasingly popular among both men and women since they provide quick refreshment and nurture the skin. Given the wide range of skin types and the chemicals used in their formulation, it can be difficult to find a product that not only complements the skin type but is also free of potentially harmful ingredients that could endanger the consumer's health. When dealing with ambiguous situations, the multi‐attribute decision making (MADM) approach combined with fuzzy set theory is more effective. Type‐2 fuzzy sets (T2FS) provide greater flexibility in dealing with uncertainty in real‐world issues since they are characterised by a main and secondary membership function. In this research, we present the innovative idea of type‐2 linear diophantine fuzzy set (T2LDFS) as an intriguing tool for capturing expert reluctance about an issue. For analysing the discussed problem, a hybrid fuzzy VIKOR enhanced with the proposed fuzzy logic is suggested. A sensitivity and comparative analysis is carried out to establish the validity of the recommended approach.
GTP‐dependent regulation of heterochromatin fluctuations at subtelomeric regions in Saccharomyces cerevisiae
Authors: Ayano Takahito , Yokosawa Takuma , Oki Masaya 
Published: January 2024

AbstractIn eukaryotes, single cells in a population display different transcriptional profiles. One of the factors regulating this heterogeneity is the chromatin state in each cell. However, the mechanisms of epigenetic chromatin regulation of specific chromosomal regions remain unclear. Therefore, we used single‐cell tracking system to analyze IMD2. IMD2 is located at the subtelomeric region of budding yeast, and its expression is epigenetically regulated by heterochromatin fluctuations. Treatment with mycophenolic acid, an inhibitor of de novo GTP biosynthesis, triggered a decrease in GTP, which caused heterochromatin fluctuations at the IMD2 locus. Interestingly, within individually tracked cells, IMD2 expression state underwent repeated switches even though IMD2 is positioned within the heterochromatin region. We also found that 30% of the cells in a population always expressed IMD2. Furthermore, the addition of nicotinamide, a histone deacetylase inhibitor, or guanine, the GTP biosynthesis factor in salvage pathway of GTP biosynthesis, regulated heterogeneity, resulting in IMD2 expression being uniformly induced or suppressed in the population. These results suggest that gene expression heterogeneity in the IMD2 region is regulated by changes in chromatin structure triggered by slight decreases in GTP.
Safety and efficacy of damoctocog alfa pegol prophylaxis in patients with severe haemophilia A: Results of an interventional, post‐marketing study
Authors: Holme Pål André , Poulsen Lone Hvitfeldt , Tueckmantel Claudia , Maas Enriquez Monika , Alvarez Román María Teresa , De Cristofaro Raimondo 
Published: January 2024

AbstractIntroductionDamoctocog alfa pegol (BAY 94‐9027, Jivi®) is an approved extended half‐life factor VIII (FVIII) for treatment of previously treated patients with haemophilia A aged ≥12 years. We report the final results of an interventional, post‐marketing study of damoctocog alfa pegol prophylaxis in patients with severe haemophilia A.MethodsIn this open‐label, interventional, post‐marketing, phase 4 trial (NCT04085458), previously FVIII‐treated patients with severe haemophilia A aged ≥18 years received damoctocog alfa pegol for ≥100 exposure days (EDs). Patients initially received 45 IU/kg every 5 days (recommended) or 40 IU/kg twice‐weekly. At Visit 3, patients’ doses could be increased, or treatment frequency adapted. The primary endpoint was FVIII inhibitor development (titre ≥.6 Bethesda units). Secondary endpoints included anti‐polyethylene glycol (PEG) antibody development, treatment‐emergent adverse events (AEs) and annualized bleeding rate (ABR).ResultsOverall, 36 patients were enrolled; 32 patients received treatment, of whom, 27 completed the study. No patients developed FVIII inhibitors; three tested transiently positive for low‐titre anti‐PEG antibodies without clinical relevance. Three patients reported study‐drug‐related AEs of mild or moderate intensity. Two patients discontinued the study due to AEs. No deaths occurred. Most patients (70%) were treated with E5D/E7D regimens. The median (Q1;Q3) total ABR (N = 30) was 3.0 (.0;9.0) pre‐study and 1.8 (.7;5.9) during the study.ConclusionDamoctocog alfa pegol individualized prophylaxis regimens were well‐tolerated with no immunogenicity concerns. ABRs improved following the switch from pre‐study prophylaxis to damoctocog alfa pegol prophylaxis. These results support the favourable safety and efficacy profile of damoctocog alfa pegol prophylaxis.
Co‐producing a board game to learn and engage about dementia inequalities: First impacts on knowledge in the general population
Authors: Giebel Clarissa , Hanna Kerry , Tetlow Hilary , Gabbay Mark , Cannon Jacqui 
Published: January 2024

AbstractBackgroundReceiving and accessing care after a diagnosis of dementia, both for the person and their carer, are fraught with inequalities. The aim of this public engagement activity was to co‐produce a board game about dementia inequalities to facilitate learning, dialogue and educate about different barriers, and facilitators, to diagnosis and care and to test the game's impact on dementia knowledge with the general public.MethodsTwo virtual and two face‐to‐face workshops with people with dementia, unpaid carers, health and social care professionals and Third Sector representatives were held between October 2022 and June 2023. Virtual workshops involved discussions of inequalities and how a board game may feature inequalities. The first face‐to‐face workshop was split into the same activities, aided by outcomes from workshops 1 and 2. Workshop 4 attendees tested the prototype. The impact of the game on knowledge about dementia and inequalities was tested at a game play workshop in October 2023.ResultsForty stakeholders attended four workshops. Workshops provided step‐by‐step thoughts on how the game could be designed or modified. The final game, prototype tested in workshop 4, consists of a one‐sided, two‐half board depicting the prediagnosis process (left half) and postdiagnosis process (right half). Fifty‐two members of the general public participated in the game play workshop, which led to significant improvements in knowledge about dementia (p < .001) and inequalities (p < .001).DiscussionThe game can be used to improve knowledge about dementia inequalities for health and social care professionals, carers, people living with dementia, decision makers and the general public.Patient or Public ContributionThis engagement activity fully involved people with dementia, unpaid carers, health and social care professionals and Third Sector representatives throughout, with two unpaid carers as public advisers on the team.
The impact of different antibiotic injection regimens on patients with severe infections: A meta‐analysis
Authors: Li Da , Mo Kanglin , Liang Binqi , Huang Yunsheng , Tan Xingling , Wang Zengrui , Yang Xia 
Published: January 2024

AbstractSevere infection is a critical health threat to humans, and antibiotic treatment is one of the main therapeutic approaches. Nevertheless, the efficacy of various antibiotic injection regimens in severe infection patients remains uncertain. This study aimed to comprehensively evaluate the impact of various antibiotic injection strategies on patients with severe infection through a meta‐analysis. Relevant research literature was collected by searching databases such as PubMed, Embase, and Cochrane Library. The retrieved literature was screened according to inclusion and exclusion criteria. Relevant data, including study design, sample size, and antibiotic regimens, were extracted from the included studies. The Cochrane Collaboration's Risk of Bias tool was employed to assess the risk of bias in each study. Statistical analysis was performed based on the results of the included studies. A total of 15 articles were included, covering various types of severe infection patients, including pulmonary and abdominal infections. The analysis provided insights into mortality rates, treatment efficacy, adverse reactions (ARs), Acute Physiology and Chronic Health Evaluation (APACHE) scores, among other outcomes. The results indicated that combination therapy was superior to monotherapy in terms of mortality rate, treatment efficacy, and APACHE scores, while the incidence of ARs was lower in the monotherapy group compared to the combination therapy group (p < 0.05). Combination therapy showed better treatment efficacy compared to monotherapy, although it was associated with a higher incidence of ARs.