bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring health related quality of life for women with breast cancer in Ireland and Québec, Canada throughout the COVID-19 pandemic
Authors: Myers Charlotte , Bennett Kathleen , Cahir Caitriona , Savard Josée , Lauzier Sophie 
Published: February 2025

Abstract
The long-term consequences from the COVID-19 pandemic on breast cancer (BC) is highly unknown, however persisting unmet needs and psychosocial difficulties are likely. The objectives of this study were to evaluate the change in health-related quality of life (HR-QoL) from the pandemic to post-pandemic for women living with a diagnosis of BC and to assess the association between COVID-19 stressor impact and HR-QoL in Ireland and Québec, Canada. Women with a diagnosis of BC were initially enrolled in the cohort study. HR-QoL was assessed during the pandemic (2020–2021) and post-pandemic periods (2022). COVID-19 stressor impact was computed post-pandemic, and change in HR-QoL during and post-pandemic was compared between Ireland and Québec using independent t-tests. Multivariable analysis of covariance (ANCOVA) was used to evaluate the association between COVID-19 stressor impact and changes in HR-QoL, and compare it between Ireland and Québec. 405 participants were included from both settings (Ireland n = 267; Québec n = 138). The average HR-QoL improved from the COVID-19 pandemic to post-pandemic, and there were no differences between Ireland and Québec. Women with high COVID-19 stressor impact (18.9% of participants) had a significantly smaller improvement in their overall HR-QoL compared to those with low COVID-19 stressor impact, and this was evident in Ireland (p < 0.004) and Québec (p < 0.0001) but there were no significant differences between Ireland and Québec (interaction p-value > 0.05). Overall, HR-QoL for women with BC improved from pandemic to post-pandemic period. However, similarly in both settings, women who experienced higher levels of COVID-19-related stress had a slower recovery in HR-QoL. These results can guide decisions about health services and policies to adequately address the on-going effect of the pandemic and also prepare for future health crises.
Changes in optic nerve head microvasculature following disc hemorrhage absorption in glaucomatous eyes
Authors: Yoon Jooyoung , Sung Kyung Rim , Kim Ko Eun , Han Hyo Ji , Kim Joon Mo 
Published: February 2025

Abstract
This study investigated the changes in optic nerve head (ONH) microvasculature, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and visual field (VF) sensitivity following the absorption of optic disc hemorrhage (DH). Intradisc vessel density (dVD) was calculated using a 3 × 3 mm optic disc scan in 60 eyes of 60 patients with primary open angle glaucoma and DH who had undergone two or more swept-source optical coherence tomography angiography exams. Clinical parameters at the time of DH occurrence and after absorption, as well as those between the subgroups based on DH recurrence and location, were compared. Linear regression analysis was performed to identify factors associated with changes in cpRNFL thickness in the DH-affected quadrant. Mean dVD, cpRNFL thickness, and VF sensitivity significantly decreased after DH absorption (all P < 0.05). The reduction in dVD was more pronounced in eyes with recurrent DH compared to those with a single episode (P = 0.032). Eyes with DH occurring within or at the margin of the disc cup showed a greater dVD reduction than those with DH occurring outside the disc cup (P = 0.049). The reduction in cpRNFL thickness in the DH-affected quadrant correlated with dVD reduction in the same quadrant (β = 0.370, P = 0.013) and DH recurrence (β = -2.617, P = 0.033). This finding suggests that DH pathogenesis may be associated with changes in optic disc vasculature, contributing to glaucomatous progression.
University digital media co-occurrence networks reveal structure and dynamics of brand visibility in the attention economy
Authors: Petersen Alexander Michael 
Published: February 2025

Abstract
As universities compete for visibility to attract student enrollment and build scientific reputation, the management of institution of higher education (IHE) brand has emerged as an important strategic endeavor. Yet our understanding of the factors that condition the structure and dynamics of brand stratification within regional IHE ecosystems is limited. Instead, our best approximation for brand equity derives from widespread IHE rankings, which lack contextual and relational features for understanding the patterns of engagement in the fast-moving attention economy, and in particular how institutional partnerships can generate brand equity by leveraging ecosystem network effects. To this end, here we develop a framework for measuring two dimensions of brand equity, namely visibility, and association, according to the frequency of digital media articles featuring a university’s official name. We demonstrate this approach for 29 universities in California and Texas based upon 2 million media articles published between 2000 and 2020 and validate our approach by correlating university digital media visibility with ARWU Shanghai rankings and freshman enrollment growth. As roughly 10% of the article sample features >1 university, longitudinal analysis of institutional co-occurrence reveals the extent to which brand association stratifies according to regional proximity, institutional specialization, and prestige. Interestingly, despite the shared value generated from media co-visibility, the frequency of multi-university media articles has declined over time, which we attribute to paradigm shifts in media content production following the 2007–08 financial crisis and the COVID-19 infodemic, in addition to increased competitiveness of the attention economy. Topic classification of media article titles shows how specialized institutions may strategically manage their brand equity by aligning content production with dominant media topics to reinforce brand visibility with broader social, technological, and environmental narratives.
Prevalence and Mortality Trends of Hypertension Subtypes Among US Adults: An Analysis of the National Health and Nutrition Examination Survey
Authors: Tang Kevin S , Jones Jeffrey E , Fan Wenjun , Wong Nathan D 
Published: February 2025

Abstract

BACKGROUND
Hypertension (HTN) has been demonstrated as one of the leading risk factors for development of cardiovascular disease (CVD) and CVD mortality.

METHODS
This study examines the prevalence and distribution of HTN subtypes (isolated diastolic hypertension [IDH], isolated systolic hypertension [ISH], and systolic-diastolic hypertension [SDH]) across age, sex, and race/ethnicity per the nationally representative National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020 based on the updated 2017 ACC/AHA HTN definition. We further examined for associations of each subtype with CVD and all-cause mortality using Cox regression analysis.

RESULTS
Among US adults, the overall prevalence of HTN is 47.4%. Across increasing age, the prevalence of IDH decreased, ISH increased, and SDH increased and peaked in the 6th decade of life after which SDH prevalence decreased. By age 80, over 80% of persons with HTN demonstrated ISH. A subcohort from NHANES 1999–2008 with follow-up until 2018 showed that ISH and SDH were most strongly associated with increased risk for CVD (HR = 1.18, 95% CI, 1.01–1.38; HR = 1.31, 95% CI, 1.07–1.60, respectively) and all-cause mortality (HR = 1.17, 95% CI, 1.06–1.28; HR = 1.21, 95% CI, 1.08–1.37, respectively).

CONCLUSIONS
Our data demonstrate the continuing importance of HTN subtype transitions across age and their differences in predicting future CVD and total mortality.
The Use of a Proprietary Near-Infrared Laser to Enhance Wound Healing: A Preliminary Pre-Clinical and Clinical Study
Authors: Glass Graeme E , Mérai András , Molnár Szabolcs , Clayton Paul 
Published: February 2025

Abstract

Background
Non-thermal light energy has been used to enhance wound healing. This is known as photobiomodulation (PBM). While preclinical evidence is largely based on laser light, light-emitting diodes (LEDs) form the mainstay of clinical studies owing to the lack of available lasers for non-clinical use. However, it is speculated the two technologies exhibit dissimilar biological responses.

Objectives
The influence of a new, commercially available near-infrared laser device on the gene expression profile of human skin relative to an equivalent, near-infrared LED device was evaluated. Additionally, the wound healing potential of the device was examined in practice.

Methods
Defatted human skin was exposed to the laser (3), LED (3) or negative control (3) for 5 days. On day 6, skin samples were biopsied for RNA extraction and gene expression assays run for 107 genes of interest. Twenty patients with chronic wounds were randomized to receive standard wound care ± laser therapy 3 times weekly for 4 weeks and wounds were analyzed for healing.

Results
The laser altered expression of 45 genes. Highly upregulated genes (&gt;5-fold change) included those implicated in wound healing and anti-ageing while highly downregulated genes included those implicated in inflammation and extracellular matrix integrity. The LED device altered expression of only one gene relative to negative controls. The laser reduced mean wound area by 78% and healed 4 of 10 wounds completely. By contrast, 8 of 10 of those receiving standard care exhibited no change.

Conclusions
A proprietary near-infrared laser exhibited superior ability to influence gene expression in healthy skin than an equivalent LED device and induced the healing of chronic wounds.
DNAdesign: feature-aware in silico design of synthetic DNA through mutation
Authors: Wang Yingfei , Li Jinsen , Chiu Tsu-Pei , Gompel Nicolas , Rohs Remo 
Published: February 2025

Abstract

Motivation
DNA sequence and shape readout represent different modes of protein–DNA recognition. Current tools lack the functionality to simultaneously consider alterations in different readout modes caused by sequence mutations. DNAdesign is a web-based tool to compare and design mutations based on both DNA sequence and shape characteristics. Users input a wild-type sequence, select sites to introduce mutations and choose a set of DNA shape parameters for mutation design.

Results
DNAdesign utilizes Deep DNAshape to provide ultra-fast predictions of DNA shape based on extended k-mers and offers multiple encoding methods for nucleotide sequences, including the physicochemical encoding of DNA through their functional groups in the major and minor groove. DNAdesign provides all mutation candidates along the sequence and shape dimensions, with interactive visualization comparing each candidate with the wild-type DNA molecule. DNAdesign provides an approach to studying gene regulation and applications in synthetic biology, such as the design of synthetic enhancers and transcription factor binding sites.

Availability and implementation
The DNAdesign webserver and documentation are freely accessible at https://dnadesign.usc.edu.
Forecasting interannual abundance of Helicoverpa zea (Lepidoptera: Noctuidae)
Authors: Wallace Samuel T , Nelson Natalie G , Reisig Dominic D , Huseth Anders S 
Published: February 2025

Abstract
Corn earworm, Helicoverpa zea Boddie (Lepidoptera: Noctuidae), is a common herbivore that causes economic damage to agronomic and specialty crops across North America. The interannual abundance of H. zea is closely linked to climactic variables that influence overwintering survival, as well as within-season host plant availability that drives generational population increases. Although the abiotic and biotic drivers of H. zea populations have been well documented, prior temporal H. zea modeling studies have largely focused on mechanistic/simulation approaches, long term distribution characterization, or degree day-based phenology within the growing season. While these modeling approaches provide insight into H. zea population ecology, growers remain interested in approaches that forecast the interannual magnitude of moth flights which is a key knowledge gap limiting early warning before crops are planted. Our study used trap data from 48 site-by-year combinations distributed across North Carolina between 2008 and 2021 to forecast H. zea abundance in advance of the growing season. To do this, meteorological data from weather stations were combined with crop and soil data to create predictor variables for a random forest H. zea forecasting model. Overall model performance was strong (R2 = 0.92, RMSE = 350) and demonstrates a first step toward development of contemporary model-based forecasting tools that enable proactive approaches in support of integrated pest management plans. Similar methods could be applied at a larger spatial extent by leveraging national gridded climate and crop data paired with trap counts to expand forecasting models throughout the H. zea overwintering range.
The impact of bicuspid valve morphology on the selection of TAVI devices: an in-silico study
Authors: Grossi Benedetta , Luraghi Giulia , Barati Sara , Forte Chiara , Gerosa Luca , Cozzi Ottavia , D’Ascenzo Fabrizio , Condorelli Gianluigi , Migliavacca Francesco , Stefanini Giulio 
Published: February 2025

Abstract

Aims
Bicuspid aortic valve (BAV) represents a challenge for transcatheter aortic valve implantation (TAVI). Few data are reported about the procedural implications of BAV using different self-expandable devices. The aim of this study is to investigate how BAV and tricuspid aortic valve (TAV) morphologies influence device selection and their impact on the potential development of post-operative conduction disturbances, using a novel in-silico approach.

Methods and Results
Five patients with BAV undergoing TAVI were enrolled. TAVs were virtually modeled within each BAV patient-specific anatomy, resulting in ten virtual patients. Acurate Neo2 and Evolut R implantations were subsequentially simulated across all cases. Post-implantation stresses exerted on both the stent and aortic root were measured, allowing a comparative analysis of the impact of the two valve morphologies.
Comparing stent stresses between BAV and TAV configurations, the stress gap increased by 21.96 ± 5.35 % (p = 0.01) in Acurate Neo2 cases (n = 6) compared to Evolut R cases (n = 4). The analysis of aortic root stresses showed no significant differences between BAV (n = 5) and TAV (n = 5) configurations, with a mean stress difference of 5.1 ± 8.17 % (p &gt; 0.05).

Conclusion
Our patient-specific model shows that high radial force devices, such as Evolut R, demonstrate consistent expansion regardless of valve morphology, without increasing the risk of post-implantation conduction disturbances, hence resulting more suitable for BAV cases. Incorporating this methodology into pre-operative planning could support clinicians in selecting the most suitable device with a patient-specific approach.
Antithrombotic therapy following transcatheter aortic valve implantation: a Danish nationwide study
Authors: Vistisen Helene Ø , Graversen Peter L , Havers-Borgersen Eva , Strange Jarl E , Østergaard Lauge , Butt Jawad H , Dahl Jordi S , Povlsen Jonas A , Terkelsen Christian Juhl , Freeman Phillip , Nissen Henrik , Køber Lars , de Backer Ole , Fosbøl Emil L 
Published: February 2025

Abstract

Background
Antithrombotic therapy post-transcatheter aortic valve implantation (TAVI) has been widely debated in the past two decades. Data describing practice patterns of antithrombotic therapy are warranted. This study examined the trends in use of antithrombotic therapy post-TAVI in Denmark.

Methods
Danish patients with aortic stenosis who underwent first-time TAVI from 2008 to 2021 were identified from Danish registries. Patients were categorized according to atrial fibrillation (AF) status and antithrombotic therapy post-TAVI based on prescription fillings. The antithrombotic therapy groups: No antithrombotic therapy, single antiplatelet therapy (SAPT), dual antiplatelet therapy (DAPT), oral anticoagulant therapy (OAC), and oral anticoagulant therapy with antiplatelet therapy (OAC+). Use of antithrombotic therapy among survivors at 15 months was examined to assess persistence and possible changes in treatment.

Results
This study included 6447 patients undergoing TAVI. Among patients without AF (n = 3975), most patients received SAPT or DAPT. In AF-patients (n = 2472), most patients received OAC or OAC + . During the first 14 years of TAVI, there was a shift in the antithrombotic treatment pattern: For patients without AF, SAPT increased from 15.6% to 69.5% with a concomitant decrease in DAPT from 56.3% to 9.1%. For AF-patients OAC increased from 13.0% to 77.9% and OAC + decreased to 9.1%. Most patients without AF either remained with or shifted to SAPT. AF-patients either remained in or shifted to the OAC group.

Conclusion
Antithrombotic therapy patterns post-TAVI has changed over the first 14 years of TAVI in Denmark. Use of DAPT and OAC + decreased with a concomitant increase in SAPT and OAC.
The materials synthesized in deep eutectic solvents for the detection of food contaminants
Authors: Fan Chen , Zhang Ruixue , Jin Ming 
Published: February 2025

Abstract
The present review delves into the burgeoning field of deep eutectic solvents (DESs) and their application in the synthesis of materials for detecting food contaminants. DESs, as a green alternative to conventional solvents, offer a sustainable platform for material synthesis with unique properties such as low toxicity, biodegradability, and excellent solvation capabilities. This review comprehensively discusses the classification, preparation methods, and properties of the materials synthesized in DESs that make them ideal for the development of sensitive and selective analytical methods for food safety. It covers the synthesis of various functional materials in DESs, including noble metal nanoparticles, metal oxides, conductive polymers, hydrogels, carbon-based materials, molecularly imprinted polymers, chalcogenide materials, and metal-organic frameworks. These materials have demonstrated enhanced stability, selectivity, and sensitivity in the detection of food contaminants such as heavy metals, pesticides, and mycotoxins. The review also highlights the challenges and future directions in the application of DES-based materials, emphasizing the need for innovative materials to address the growing demand for rapid, accurate, and cost-effective food contaminant detection methods. By showcasing the latest research and developments, this review underscores the potential of materials synthesized with DESs in revolutionizing food safety monitoring through the detection and monitoring of contaminants in food products.
“Where it’s okay if we die”: exploring older Canadians’ perspective on long-term care through found poetry
Authors: Joanisse Camille , Oostlander Samantha A , Mulvey Michael S , Garcia Linda , Harrisson Sandra , Lagacé Martine , Fraser Sarah , Robitaille Annie , Gillis Margaret , Courtemanche Jill , O’Sullivan Tracey L 
Published: February 2025

Abstract
The thought of living in a nursing home may be disheartening as long-term care establishments have been poorly perceived for decades. The government oversight for quality of care in long-term care homes (LTCH) has resulted in persistent shortcomings when it comes to residents’ well-being and health. The COVID-19 pandemic both exacerbated and unveiled long-standing issues regarding the treatment of older adults. Public perceptions about quality of care provided in LTCH declined during the pandemic. With magnification focused on organizational issues in LTCH, future care receivers expressed firm reluctance to consider residence in such facilities. Understanding of older adults’ perspectives on LTCH is essential for tailoring care practices and policies. In this study we conducted two rounds of interviews with community-dwelling older adults aged 65 or over to better understand their perceptions of LTCH. The narrative data were analyzed using found poetry as an artistic inquiry. Six poems were composed, combining participants’ words into one poetic voice - addressing themes such as death, isolation, ongoing healthcare challenges and private care. Found poetry allowed for salient words to emerge, creating space for nuanced expression of emotions. The combination of multiple voices added to the depth of the poems, which were grounded in the participants’ reality.
Haplotype-resolved genome of Agastache rugosa (Huo Xiang) provides insight into monoterpenoid biosynthesis and gene cluster evolution
Authors: Liu Chanchan , Li DiShuai , Dang Jingjie , Shu Juan , Smit Samuel J , Wu QiNan , Lichman Benjamin R 
Published: February 2025

Abstract
Monoterpenoids are small volatile molecules produced by many plants that have applications in consumer products and healthcare. Plants from the mint family (Lamiaceae) are prodigious producers of monoterpenoids, including a chemotype of Agastache rugosa (Huo Xiang), which produces pulegone and isomenthone. We sequenced, assembled and annotated a haplotype-resolved chromosome-scale genome assembly of A. rugosa with a monoterpene chemotype. This genome assembly revealed that pulegone biosynthesis genes are in a biosynthetic gene cluster, which shares a common origin with the pulegone gene cluster in Schizonepeta tenuifolia. Using phylogenetics and synteny analysis, we describe how the clusters in these two species diverged through inversions and duplications. Using Hi-C analysis, we identified tentative evidence of contact between the pulegone gene cluster and an array of pulegone reductases, with both regions also enriched in retrotransposons. This genome and its analysis add valuable and novel insights to the organization and evolution of terpenoid biosynthesis in Lamiaceae.