bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow
Authors: Zhang Yongli , Lin Chenxiang 
Published: January 2024

AbstractNonvesicular lipid transport among different membranes or membrane domains plays crucial roles in lipid homeostasis and organelle biogenesis. However, the forces that drive such lipid transport are not well understood. We propose that lipids tend to flow towards the membrane area with a higher membrane protein density in a process termedlipid osmosis. This process lowers the membrane tension in the area, resulting in a membrane tension difference calledosmotic membrane tension. We examine the thermodynamic basis and experimental evidence of lipid osmosis and osmotic membrane tension. We predict that lipid osmosis can drive bulk lipid flows between different membrane regions through lipid transfer proteins, scramblases, or other similar barriers that selectively pass lipids but not membrane proteins. We also speculate on the biological functions of lipid osmosis. Finally, we explore other driving forces for lipid transfer and describe potential methods and systems to further test our theory.
Regulation of the aurantio-obtusin accumulation by StTCP4.1-mediated StDA1-StHDR1 module inSenna toraseeds
Authors: Liu Shuang , Liu Jinling , Abozeid Ann , Yin Xuecui , Dong Juane , Liang Zongsuo 
Published: January 2024

AbstractSenna tora(S. tora) is a commonly used Chinese medicinal plant due to the presence of the bioactive compounds anthraquinones in its mature seeds. Seed size is an important factor that affectS. torayield quantity and quality. However, the mechanism regulating seed size and aurantio-obtusin biosynthesis inS.torais still unclear. In this study, we identified the ubiquitin receptor StDA1 inS.torathat served as a negative regulator to seed formation and limited seed enlargement. Antisense overexpression of StDA1 led to larger seeds inS. toraand promoted the accumulation of aurantio-obtusin. In contrast, overexpression of StDA1 inS.toraresulted in a relative decrease in aurantio-obtusin accumulation. Moreover, StDA1 can directly bind to StHDR1and regulate its degradation through the 26S proteasome to regulate seed size and aurantio-obtusin accumulation. We also found that the StDA1-StHDR1 module is responsive to the MeJA via StTCP4.1, which in turn affects the accumulation of aurantio-obtusin. Overall, we have identified a protein complex that regulates the accumulation of aurantio-obtusin, StTCP4.1-StDA1-StHDR1, as a potential target for improvingS.torayield quantity and quality.
Identification of candidate genes controlling red seed coat color in cowpea (Vigna unguiculata[L.] Walp)
Authors: Herniter Ira A. , Muñoz-Amatriaín María , Lo Sassoum , Guo Yi-Ning , Lonardi Stefano , Close Timothy J. 
Published: January 2024

AbstractSeed coat color is an important consumer-related train in cowpea (Vigna unguiculata[L.] Walp.) and has been a subject of study for over a century. Utilizing newly available resources, including mapping populations, a high-density genotyping platform, and several genome assemblies, red seed coat color has been mapped to two loci,Red-1(R-1) andRed-2(R-2), on Vu03 and Vu07, respectively. A gene model (Vigun03g118700) encoding a dihydroflavonol 4-reductase, a homolog of anthocyanidin reductase 1, which catalyzes the biosynthesis of epicatechin from cyanidin, has been identified as a candidate gene forR-1. Possible causative variants have been also identified forVigun03g118700. A gene model on Vu07 (Vigun07g118500), with predicted nucleolar function and high relative expression in the developing seed, has been identified as a candidate forR-2. The observed red color is believed to be the result of a buildup of cyanidins in the seed coat.
A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinson’s disease: key roles for TRPM2, Zn2+and complex III
Authors: AlAhmad Maali , Isbea Hala , Shitaw Esra , Li Fangfang , Sivaprasadarao Asipu 
Published: January 2024

ABSTRACTReactive oxygen species (ROS) serve vital physiological functions, but aberrant ROS production contributes to numerous diseases. Unfortunately, therapeutic progress targeting pathogenic ROS has been hindered by limited understanding of whether the mechanisms driving pathogenic ROS differ from those governing physiological ROS generation. To address this knowledge gap, we utilised a cellular model of Parkinson’s disease (PD), as an exemplar of ROS-associated diseases. We exposed SH-SY5Y neuroblastoma cells to the PD-toxin, MPP+(1-methyl-4-phenylpyridinium) and studied ROS upregulation leading to cell death, the primary cause of PD. We demonstrate: (i) MPP+stimulates ROS production by raising cytoplasmic Ca2+levels, rather than acting directly on mitochondria. (ii) To raise the Ca2+, MPP+co-stimulates NADPH oxidase-2 (NOX2) and the TRPM2 (Transient Receptor Potential Melastatin2) channel that form a positive feedback loop to support each other’s function. (iii) Ca2+exacerbates mitochondrial ROS (mtROS) production not directly, but via Zn2+. (iv) Zn2+promotes electron escape from respiratory complexes, predominantly from complex III, to generate mtROS. These conclusions are drawn from data, wherein inhibition of TRPM2 and NOX2, chelation of Ca2+and Zn2+, and prevention of electron escape from complexes -all abolished the ability of MPP+to induce mtROS production and the associated cell death. Furthermore, calcium ionophore mimicked the effects of MPP+, while Zn2+ionophore replicated the effects of both MPP+and Ca2+. Thus, we unveil a previously unrecognized signalling circuit involving NOX2, TRPM2, Ca2+, Zn2+, and complex III that drives cytotoxic ROS production. This circuit lies dormant in healthy cells but is triggered by pathogenic insults and could therefore represent a safe therapeutic target for PD and other ROS-linked diseases.
Complex interplay of R&D, advertising and exports in USA manufacturing firms: differential effects of capabilities
Authors: Kwon He-Boong , Lee Jooh , Brennan Ian 
Published: January 2024

PurposeThis study aims to explore the dynamic interplay of key resources (i.e. research and development (R&D), advertising and exports) in affecting the performance of USA manufacturing firms. Specifically, the authors examine the dynamic impact of joint resources and predict differential effect scales contingent on firm capabilities.Design/methodology/approachThis study presents a combined multiple regression analysis (MRA)-multilayer perceptron (MLP) neural network modeling and investigates the complex interlinkage of capabilities, resources and performance. As an innovative approach, the MRA-MLP model investigates the effect of capabilities under the combinatory deployment of joint resources.FindingsThis study finds that the impact of joint resources and synergistic rents is not uniform but rather distinctive according to the combinatory conditions and that the pattern is further shaped by firm capabilities. Accordingly, besides signifying the contingent aspect of capabilities across a range of resource combinations, the result also shows that managerial sophistication in adaptive resource control is more than a managerial ethos.Practical implicationsThe proposed analytic process provides scientific decision support tools with control mechanisms with respect to deploying multiple resources and setting actionable goals, thereby presenting pragmatic benchmarking options to industry managers.Originality/valueUsing the theoretical underpinnings of the resource-based view (RBV) and resource orchestration, this study advances knowledge about the complex interaction of key resources by presenting a salient analytic process. The empirical design, which portrays holistic interaction patterns, adds to the uniqueness of this study of the complex interlinkages between capabilities, resources and shareholder value.
Exploring the application of PLS-SEM in construction management research: a bibliometric and meta-analysis approach
Authors: Batra Sachin 
Published: January 2024

PurposeThe partial least squares structural equation modeling (PLS-SEM) approach for construction management (CM) scholars has become the preferred approach for its capability of assessing the complex relationship and relaxed normality and sample size assumptions. This paper systematically maps the structure of knowledge about PLS-SEM in CM using bibliometric analysis. Also, the study employs meta-analysis to explore how data and model characteristics, model evaluation and advanced modeling techniques have been utilized in the CM domain.Design/methodology/approachThis study integrated two methods: bibliometric analysis on a sample of 211 articles identified using the PRISMA framework and meta-analysis on 163 articles identified based on the availability of full-length articles and relevant information.FindingsThe results revealed the leading knowledge formation entities (countries, institutions, authors, sources and documents). Also, the study employs full content analysis to identify six research themes, and meta-analysis is used to explore the use of PLS-SEM based on the following criteria: (1) reasons for using PLS-SEM in CM, (2) data characteristics, (3) model characteristics and evaluation and (4) use of advanced modeling and analysis techniques. Further, the study uses regression analysis and identifies “advanced modeling and analysis techniques” as the critical feature responsible for the publication in a journal with high scientific prestige. Finally, the study presented the comprehensive guidelines to be used by construction management scholars who wish to use PLS-SEM in their research work.Originality/valueTo the author’s knowledge, it is the first study of this kind to use PLS-SEM in CM research. This study provides an extensive analysis of the Scopus database and an in-depth review of the data characteristics, model characteristics and use of advanced modeling techniques in CM research.
The valuation and determinants of franking account balances
Authors: Han Lin , Hu Hansi , Walter Terry 
Published: January 2024

PurposeAre franking credit balances priced? This paper aims to investigate the valuation of franking credit balances via a determinant analysis and value relevance analysis.Design/methodology/approachThe determinant analysis examines the factors that contribute to the increasing cumulative level of franking credit balances. Value relevance studies explore whether franking credit balances are priced in the market.FindingsThe results provide strong evidence of a size effect that the level of franking credit balances increases with firm size and weak evidence of an international focus effect that the level of franking credit balances increases with international ownership. They also find an individual dividend clientele effect that the level of franking credit balances decreases with individual ownership. They find significant evidence that franking credit balances are priced in the market. One dollar of franking credit is worth 1.4 dollars in firm value. That franking balances are capitalized at more than their face value suggests that franking credits signal firms' future dividend policy. They also find that the market valuation of franking balances increases with firm size but decreases with international focus.Originality/valueThis study provides direct evidence that franking credit balances are capitalized into equity prices. In the determinant analysis, this paper improves Heaney's (2009) model by using the percentage of international ownership as the proxy of international focus, thus addressing the limitation of his measure. In the value relevance tests, the study uses a modified model that includes log-transformation to reduce the skewness of variables based on Tanza's (2014) value relevance model. Moreover, the study suggests that the market valuation of franking credit balances increases with firm size, which contradicts Heaney's (2009) findings.
Impact of dividend policy on corporate social responsibility: the role of board governance mechanism
Authors: Farooq Muhammad , Ahmed Asrar , Khan Imran , Munir Muhammad 
Published: January 2024

Purpose
This study aims to investigate the impact of dividend policy on a firm’s participation in corporate social responsibility (CSR)-related activities in the context of Pakistani firms. Furthermore, the role of the board governance mechanism in dividend policy-CSR is investigated.

Design/methodology/approach
The study’s sample consists of 115 nonfinancial Pakistan Stock Exchange-listed firms from 2010 to 2021. A multidimensional financial method is used to assess the firm’s CSR engagement, and dividend policy is assessed using the dividend payout ratio and dividend yield. The authors used the fixed effect model and the random effect model to fulfill the study’s objectives. Furthermore, the system-generalized method of moment estimation technique is used to test the robustness of the result. In addition, the authors perform reverse causality analysis and investigate the effect of financial constraints on the dividend policy–CSR relationship.

Findings
The authors find that dividend policy has a significant positive impact on CSR. The authors also find that dividend policy is significantly positively associated with components of CSR, i.e. donation, employee welfare and research and development. Furthermore, the authors find that the board governance mechanism strengthens this positive relationship between dividend policy and CSR.

Practical implications
The government and authorities must mandate or at least encourage enterprises to pay dividends as doing so not only keeps shareholders happy but also encourages firms to make CSR initiatives to balance stakeholders. Furthermore, the regulator should take steps to strengthen the board governance structure as it strengthens the positive dividend policy–CSR relationship.

Originality/value
Although little previous research has focused on the CSR-dividend policy link, the authors believe that this is the first study to look at the influence of dividend policy on CSR and the moderating impact of board governance mechanisms in an emerging country, namely, Pakistan.
Users' involvement in digital health collaborative projects
Authors: García-Rayado Jaime , Callens Chesney 
Published: January 2024

PurposeThis research analyzes the roles of users in innovative digital health collaborative projects from the perspective of the user by considering three dimensions: their motivation, project activities and the support of the partnership for their effective involvement.Design/methodology/approachThe authors unraveled profiles of users by using a Q-methodological analysis of 24 statements and 44 service users. The statements for the three dimensions were designed according to previous models of stakeholder identification and customer participation in new product management.FindingsThe authors obtained two profiles that advocate active participation of users, though with a different degree of involvement. One of them supports the role of users as “advisors” of users' preferences and needs, and the other indicates a higher involvement of users as “cocreators” of the innovation, with the same contribution and responsibility as the other partners.Originality/valuePrevious research has analyzed user involvement in digital health, as part of wider research on factors leading to the success and adoption of innovations. Moreover, previous research has analyzed user involvement in innovation projects, but without differentiating between projects carried out by an individual organization and those conducted by a partnership. This research contributes to filling this gap by revealing users' expectations about their involvement and how they think they will fit in with the dynamics of collaborative projects.
Fast, fresh, healthy and halal: a mobile food app recipe for Muslim millennial loyalty
Authors: Suhartanto Dwi , Dean David , Amin Hanudin , Sugiama Aceng Gima , Amalia Fatya Alty 
Published: January 2024

Purpose
The purpose of this study is to apprise mobile loyalty to halal food purchasing, including food quality, mobile quality, perceived value and satisfaction as its causes, and analyze the halal trust and health risk moderating role on the connections between mobile loyalty and its determinants.

Design/methodology/approach
A total of 307 responses from millennial Muslims were collected from the Bandung region of Indonesia via an online survey. Partial least squares modeling was applied to review the proposed mobile loyalty model.

Findings
This research found that the mobile loyalty model integrating halal food quality, mobile service quality, perceived value and satisfaction has satisfactory goodness of fit. The research confirms the function of mobile service quality but not halal food quality as drivers of mobile loyalty. Next, this study suggests that halal trust and health risks do not moderate the association between mobile loyalty and its determinants.

Practical implications
This study recommends that managers devote resources to upgrading the quality of their mobile apps to build loyalty. Offering high-quality halal food is also an important driver of millennial Muslim satisfaction.

Originality/value
To the best of the authors’ knowledge, this research is the first to investigate mobile loyalty in halal food.
Does managerial overconfidence affect capital structure rebalancing for entrepreneurial firms?
Authors: Carvalho António , Pacheco Luís Miguel , Sardo Filipe , Serrasqueiro Zelia 
Published: January 2024

PurposeThe behavioural theory adds a new paradigm of analysis with the assumptions of the decision maker’s cognitive biases and their repercussions on financing decisions. The aim of the study is to analyse the repercussions of these biases on the adjustment speed of firm’s capital structure toward the optimal level.Design/methodology/approachBased on a partial adjustment model, the study uses the Dynamic Panel Fractional estimator to analyse panel data from 4,990 Portuguese entrepreneurial firms.FindingsThe results show that the cognitive overconfidence bias impacts the entrepreneurial firm’s capital structure. In fact, the firms run by overconfident managers adjust more slowly than their counterparts. Furthermore, the findings suggest that entrepreneurial firms make relatively fast adjustments toward the optimal debt level and follow a hierarchical financing order in the funding process.Practical implicationsThe results of this paper are not only interesting to the academia, but also contain practical implications for corporate, institutional and business policy and governance. First, the paper introduces a new measure of cognitive bias in optimistic managers, which is useful for current and future academic research. Also, in practical terms, the findings of the paper reveal that when a company is contemplating hiring a manager, it should consider whether they need an optimistic or non-optimistic manager based on the company's present life cycle or situation.Originality/valueThe current analysis extends the existing literature. The study suggests that financial classical and behavioural paradigms should not be separated, which can provide evidence to help narrow the gap between these two major perspectives.
Waste management behaviour in the most populated capital city of the world
Authors: Chawla Raunaq , Soreng Eric , Kumar Avinash 
Published: January 2024

PurposeA prime objective of the Swachh Bharat Abhiyan (SBA; Clean India Mission) is to motivate people to segregate their household waste. The purpose of this study is to assess the ground reality of waste management behaviour of Delhi residents with the help of a modified Value–Belief–Norm (VBN) model. Past researches point the need to include cost as a variable in the VBN model. This study fulfils this need and tests cost as one of the variables on the gathered data.Design/methodology/approachThe research data were gathered by interacting with the people and the civic staff in the jurisdiction of the three Delhi municipalities through a stratified sampling technique (N = 250). The structural equation modelling was used to analyse the collected data.FindingsThe modified VBN model explains the waste management behaviour, but the variables do not follow the exact causal chain. Values, awareness of consequences, ascription of responsibility and personal norms all explain the resident's waste management behaviour. However, cost limits the resident's waste management behaviour.Research limitations/implicationsThe study could only achieve a moderate model fit; its sample size was small; and data were collected through self-reported questionnaire.Practical implicationsThree main practical implications of the study are: (1) While designing waste management solutions, due importance must be given to the cost to be borne by people for adopting these solutions. (2) Design such interventions that target residents' values to convince them to make the desired behavioural change. (3) People need be educated about the ways to sort waste and made aware of the importance of waste segregation in eradicating the urban waste mess.Originality/valueThe paper is an original contribution to testing a modified VBN model in predicting waste management behaviour. The modified model includes cost as a variable missing in the previous research. This research is useful in the backdrop of the SBA and provides suggestions for policymakers and pro-environment researchers.
Lessons learned through interprofessional education: exploring collaboration with elementary education, special education and communication sciences and disorders pre-service professionals
Authors: Bowers Lisa M. , Young Heather D. , Speight Renee 
Published: January 2024

PurposeInterprofessional practice (IPP) is one way to structure collaborations to more effectively meet the complex needs of students in educational settings. This article explores the lessons learned when one research team implemented interprofessional education (IPE) experiences in partnership with a public elementary school and pre-service professionals from elementary education, special education and communication science and disorders.Design/methodology/approachThis reflective article explores the lived experiences of researchers and partners who completed an IPE experience within one professional development school’s site. Researcher anecdotes are included to support the viewpoints shared.FindingsIt was discovered that IPE experiences are essential to facilitate meaningful collaborations for pre-service professionals to learn with and from one another; however, this requires time, preparation and is most effective when teacher mentors and university professors lead with vulnerability and model flexibility. Investment in IPE is challenging but worth the effort when learning outcomes are realized.Originality/valueSpecific details regarding the structure of this experience are shared as well as future directional goals for programs hoping to implement IPE in their professional practice programs.