bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a synthesis of cognitive behaviour therapy via component analysis of self‐regulation
Authors: Arco Lucius 
Published: October 2023

AbstractThe cognitive behavioural therapies (CBTs) are the choice psychotherapies for many clinicians treating a wide range of adult psychological disorders including various anxieties, mood, substance use, eating, schizophrenia and personality‐related. Empirical research in the CBTs is ever increasing, and the accumulating evidence supporting efficacious treatments is substantial and well documented. However, with prolific research comes a seemingly accelerating and worrying trend of purportedly different therapies, and numerous hybrids and combinations of therapies and techniques. For many clinicians this is increasingly confusing and not helpful in clinical practice. This article is a critique of current trends and directions in clinical research, which show signs of limited effectiveness, fragmentation, and obfuscation. An alternative strategy is proposed—examining transdiagnostic therapeutic effects, which appear related to treating pervasive dysregulated emotions, with component analyses of four principal self‐regulation components (viz., self‐monitoring; functional analysis; identifying values, goals and treatment‐plans; and feedback). Such a strategy is likely to lead to a more coherently synthesized and effective CBT.
Testing geological proxies for deep‐time tidal model simulations
Authors: Guo B. , Fitzgerald L. A. M. , Hewitt J. M. , Pampaloni O. , Green J. A. M. 
Published: October 2023

AbstractTides are a key driver of a range of Earth system processes, and we now have the capacity to simulate tidal dynamics on a range of temporal and spatial scales. Deep‐time tidal model simulations have been used to provide insight into past ocean circulation patterns, evolution of life and the developments of the Earth‐Moon system's orbital configuration. However, these tidal model simulations are relatively poorly constrained and validated because of a lack of readily available proxies. The feasibility of using two types of proxy is explored here; (1) sedimentary deposits which can directly estimate palaeotidal ranges, and (2) black shale, to constrain three palaeotidal model simulations for different time slices. Specifically, three palaeotidal range proxies were used for the early Devonian (400 Ma), three palaeotidal range proxies and five black shales for the lower Jurassic (185 Ma), and eight black shales for the early Cretaceous (95 Ma). Both tidal proxies confirm the tidal model results in most locations. The model results for 400 Ma and 185 Ma matched 2/3 of the palaeotidal range proxies for each of these periods. The locations of black shale were compared with tidal front locations predicted by the model outputs based on the Simpson–Hunter parameter and the model results from 95 to 185 Ma agree with the black shale proxies in 10/13 of the locations. In the cases where there is a disagreement, the model resolution is probably too low to fully resolve the details of the coastal topography, or—in one case—the palaeobathymetry is incorrect. Consequently, it is argued that it is worth expanding this type of work, and that such data can be used to validate both models and reconstructions.
A multifaceted review on aureusidin in planta distribution, (bio)synthesis, and bioactivities
Authors: Huang Wenqi , Lin Shiye , Farag Mohamed , Xiao Jianbo 
Published: October 2023

AbstractAureusidin, a derivative of aurone, imparts a vibrant yellow hue to numerous yellow‐rich plants, such as sunflowers and snapdragons. The bright yellow color provides an excellent pigment of choice for plant breeders to cultivate different‐colored hybrid species. The biosynthesis of aureusidin relies on a key aureusidin synthase enzyme, which belongs to the plant polyphenol oxidase family. The revelation of its DNA sequence, coupled with transgenic technology, has opened up possibilities for producing exceptionally stunning flower plants. Moreover, aureusidin exhibits remarkable bioactivities in vitro, including anti‐microbial, anti‐viral, anti‐cancer, anti‐inflammatory, anti‐oxidant, anti‐diabetic, anti‐hypercholesterolemic, anti‐hyperuricemia, histone deacetylase inhibitory, and neuropharmacological properties. However, the majority of studies have focused on in vitro experiments, rather than in vivo disease models, toxicological assessments, and human clinical trials. This review provides a comprehensive overview of all research advancements pertaining to aureusidin highlighting future perspectives to maximize its value, hereby contributing to the application of medicine, agricultural, and biotechnology fields. More studies are needed in the future to assess its toxicology, safety, and biotransformation for potential incorporation in future nutraceuticals.
Dehydroepiandrosterone mediates associations between trauma‐related symptoms and anterior pituitary volume in children and adolescents
Authors: Picci Giorgia , Casagrande Chloe C. , Ott Lauren R. , Petro Nathan M. , Christopher‐Hayes Nicholas J. , Johnson Hallie J. , Willett Madelyn P. , Okelberry Hannah J. , Wang Yu‐Ping , Stephen Julia M. , Calhoun Vince D. , Wilson Tony W. 
Published: October 2023

AbstractIntroductionThe anterior pituitary gland (PG) is a potential locus of hypothalamic–pituitary–adrenal (HPA) axis responsivity to early life stress, with documented associations between dehydroepiandrosterone (DHEA) levels and anterior PG volumes. In adults, elevated anxiety/depressive symptoms are related to diminished DHEA levels, and studies have shown a positive relationship between DHEA and anterior pituitary volumes. However, specific links between responses to stress, DHEA levels, and anterior pituitary volume have not been established in developmental samples.MethodsHigh‐resolution T1‐weighted MRI scans were collected from 137 healthy youth (9–17 years; Mage = 12.99 (SD = 1.87); 49% female; 85% White, 4% Indigenous, 1% Asian, 4% Black, 4% multiracial, 2% not reported). The anterior and posterior PGs were manually traced by trained raters. We examined the mediating effects of salivary DHEA on trauma‐related symptoms (i.e., anxiety, depression, and posttraumatic) and PG volumes as well as an alternative model examining mediating effects of PG volume on DHEA and trauma‐related symptoms.ResultsDHEA mediated the association between anxiety symptoms and anterior PG volume. Specifically, higher anxiety symptoms related to lower DHEA levels, which in turn were related to smaller anterior PG.ConclusionsThese results shed light on the neurobiological sequelae of elevated anxiety in youth and are consistent with adult findings showing suppressed levels of DHEA in those with greater comorbid anxiety and depression. Specifically, adolescents with greater subclinical anxiety may exhibit diminished levels of DHEA during the pubertal window, which may be associated with disruptions in anterior PG growth.
A tough injectable self‐setting cement‐based hydrogel for noninvasive bone augmentation
Authors: Jin Peng , Xia Mingjie , Hasany Masoud , Feng Pan , Bai Jing , Gao Jian , Zhang Wei , Mehrali Mehdi , Wang Ruixing 
Published: October 2023

AbstractComposite hydrogels with excellent properties can open new opportunities to terminate the need for auto/allografts in bone augmentations. However, their clinical application has been limited by their insufficient mechanical strength and lack of osteoinductivity. Here we report a new strategy to design an injectable bioactive double network hydrogel reinforced by inorganic calcium/magnesium phosphate cement (CMPC) hydrates to meet the mechanical performance requirements for bone regeneration. The engineered CMPC hydration endows the composite hydrogel with an appropriate gelation time and temperature for injection, which shows no harm in the defect site. CMPC hydrates could also provide a lower swelling ratio and higher biodegradation rate fitting the in vivo bone regeneration needs. In vitro and in vivo experiments prove that the ions released from inorganic particles endow biocompatibility, cell migration, adhesion, differentiation, and significantly higher bone regeneration capacity. Taken together, the simple addition of CMPC particles imparts in‐demand features that bring us closer to the clinical utilization of hydrogel‐based materials for bone regeneration.
Clinical performance of the novel full‐genotyping OncoPredict HPV Quantitative Typing assay using the VALGENT framework
Authors: Cocuzza Clementina Elvezia , Dhillon Sharonjit Kaur , Martinelli Marianna , Giubbi Chiara , Njoku Ruth Chinyere , Bhatia Ramya , Cuschieri Kate , Arbyn Marc 
Published: October 2023

AbstractClinical validation of human papillomavirus (HPV) assays according to international criteria is prerequisite for their implementation in cervical cancer screening. OncoPredict HPV Quantitative Typing (QT) assay (Hiantis Srl, Milan, Italy) is a novel full‐genotyping multiplex real‐time PCR quantitative assay targeting E6/E7 genes, allowing individual viral load determination of 12 high‐risk (HR) HPV types. Quality controls for sample adequacy, efficiency of nucleic acid extraction and PCR inhibition are included in the assay. Clinical performance of OncoPredict HPV QT test was assessed as part of the “Validation of HPV Genotyping Tests” (VALGENT‐2) framework, consisting of 1300 cervical liquid‐based cytology (LBC) samples of women aged between 20 and 60 years who had originally attended for routine cervical screening in Scotland. The clinical accuracy of the OncoPredict HPV QT (index test) for the detection of CIN2+ was assessed relative to the GP5+/6+ Enzyme ImmunoAssay (GP5+/6+ EIA) (comparator test), using noninferiority criteria. Intra‐ and interlaboratory reproducibility of the assay was assessed on a subpopulation, comprising 526 samples. The relative sensitivity and specificity for OncoPredict HPV QT vs GP5+/6+‐PCR‐EIA were 1.01 (95% CI: 0.99‐1.03) and 1.03 (95% CI: 1.0‐1.06) respectively. The P‐values for noninferiority were ≤0.001. The intra‐ and inter‐laboratory reproducibility demonstrated a high concordance (>98.7%) with kappas for individual types ranging from 0.66 to 1.00. OncoPredict HPV QT fulfills the international validation criteria for the use of HPV tests in cervical cancer screening.
Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis
Authors: Yu Ziqi , Dong Xue , Song Mei , Xu Aizhang , He Qing , Li Huilin , Ouyang Wen , Chouchane Lotfi , Ma Xiaojing 
Published: October 2023

AbstractUBR5 is a HECT domain E3 ubiquitin ligase that is frequently amplified in breast, ovarian and prostate cancers. Heightened UBR5 expression plays a profound role in tumor growth through immune‐dependent mechanisms; however, its mode of action in driving tumor metastasis has not been definitively delineated. Herein, we used a tetracycline (Tet)‐inducible RNAi‐mediated expression silencing cell system to investigate how UBR5 enables postsurgical mammary tumor metastatic growth in mouse lungs without the continuous influence of the primary lesion. In vitro, Ubr5 knockdown induces morphological and molecular changes characteristic of epithelial‐mesenchymal transition (EMT). In vivo, UBR5 promotes lung metastasis in an E3 ubiquitin ligase‐dependent manner. Moreover, doxycycline‐induced UBR5 expression knockdown in metastatic cells in the lungs, following removing the primary tumors, resulted in increased apoptosis, decreased proliferation and prolonged survival, whereas silencing the expression of cell division cycle 73 (CDC73), a tumor suppressor and E3 ligase substrate of UBR5, reversed these effects. Transcriptome analyses revealed a prominent role of the p53 pathway in dovitinib‐induced apoptosis of tumor cells differentially regulated by UBR5 and CDC73. In human triple‐negative breast cancer (TNBC) patient specimens, a strong inverse correlation was observed between UBR5 and CDC73 protein levels, with reduced CDC73 expression at metastatic sites compared to primary lesions. Furthermore, a xenograft model of human TNBC recapitulated the metastatic properties and characteristics of the unique UBR5‐CDC73 functional antagonism. This study reveals the novel and critical roles and intricate relationships of UBR5, CDC73 and p53 in postsurgical breast cancer metastasis and indicates the potential of targeting this pathway in cancer therapy.
Multiencoder‐based federated intelligent deep learning model for brain tumor segmentation
Authors: Soni Vaibhav , Singh Nikhil Kumar , Singh Rishi Kumar , Tomar Deepak Singh 
Published: October 2023

AbstractGlioma, a primary tumor derived from brain glial cells, is around 45% of all intracranial tumors. Magnetic resonance imaging's (MRI's) precise glioma segmentation is crucial for clinical purposes. This article presents a novel automatic brain tumor segmentation approach based on a multi‐encoder‐based federated intelligent deep learning framework. The suggested method uses a U‐shaped network design that multiplies the single contraction path into several paths to explore semantic information modalities deeply. The basic convolutional layer uses an Inception module and dilated convolutions to extract multi‐scale features from the images using artificial intelligent. To emphasize segmentation‐related information while ignoring redundant channel dimension information and improving the accuracy of network segmentation, lightweight channel attention efficient channel attention (ECA) modules are inserted into the bottleneck layer and decoder. The collection of data for the 2018 Brain Tumor Segmentation Challenge (BraTS 2018) is used to test the effectiveness of the suggested structure, and the findings indicate that the growth core, for the entire tumor and the augmented tumor regions, respectively, the average Dice coefficients are 0.880, 0.784, and 0.757. These findings support the proposed algorithm's ability to accurately and successfully segregate multimodal MRI brain tumors.
A community‐driven social knowledge management framework for bridging rural–urban knowledge divide using social technology
Authors: Basak Jayanta , Bhaumik Parama 
Published: October 2023

AbstractThis article illustrates how a social knowledge management (SKM) platform can be conceptualized, developed and implemented that can provide users with multi‐community connectivity, making it quicker and easier for members to connect, communicate, collaborate, and learn. By conducting case studies on rural craft producers in West Bengal, India, we have demonstrated how this platform fosters meaningful collaboration among rural artisans and various stakeholders within the craft production system, ultimately resulting in the formation of vibrant virtual communities. The platform promotes purposeful knowledge exchanges among variety of agents, which helps to reduce the knowledge divide and the market isolation that rural artisans experience. The platform enhances inter and intra‐group communication that supports rural artisans to establish their independent credibility in their trade without the assistance of intermediaries or middlemen.
Comorbidity in lipoprotein apheresis: Their role in the era of new lipid‐lowering therapies
Authors: Sbrana Francesco , Pianelli Mascia , Luciani Roberta , Bigazzi Federico , Corciulo Carmen , Ripoli Andrea , Sampietro Tiziana , Dal Pino Beatrice 
Published: October 2023

AbstractBackgroundDespite advance in pharmacotherapy of lipid disorders, lipoprotein apheresis (LA) plays a leading role in the management of severe hypercholesterolemia and in atherosclerosis prevention.MethodsAim of this study was to retrospectively evaluate Charlson Comorbidity Index (CCI), presence of major comorbidity, and/or concomitant polypharmacy (definite as 5+ drugs daily) in patients with inherited dyslipidemias on chronic LA.ResultsSince 1994, we performed more than 500 LA treatment/year and followed a total of 83 patients (age 56 [47–65] years, male 75%). In subjects with more than 5 years of LA treatment (38 patients, age 54 [45–62] years, male 66%), at the end of the observation time (9 [7–16] years), patients had higher CCI, polypharmacy, anemia, heart failure, peptic ulcer disease, and benign prostatic hyperplasia.DiscussionEven in the era of new lipid‐lowering therapies, the LA treatment established itself as a safe and lifesaving intervention. Patients on chronic LA require a multidisciplinary approach to address their comorbidity and the apheresis unit's medical staff (doctors and nurses) play a pivotal role creating a bridge toward the general practitioner and other specialists for overcoming clinical issues.
Sketching assessment in engineering education: A systematic literature review
Authors: Merzdorf Hillary E. , Jaison Donna , Weaver Morgan B. , Linsey Julie , Hammond Tracy , Douglas Kerrie A. 
Published: October 2023

AbstractBackgroundSketching exists in many disciplines and varies in how it is assessed, making it challenging to define fundamental sketching skills and the characteristics of a high‐quality sketch. For instructors to apply effective strategies for teaching and assessing engineering sketching, a clear summary of the constructs, metrics, and objectives for sketching assessment across engineering education and related disciplines is needed.PurposeThis systematic literature review explores sketching assessment definitions and approaches across engineering education research.Methodology/ApproachWe collected 671 papers from five major engineering and education databases at all skill levels for reported sketching constructs and metrics, cognition, and learning contexts. Based on the selection criteria, we eliminated all but 41 papers, on which we performed content analysis.Findings/ConclusionsEngineering, design, and art emerged as three major disciplines in the papers reviewed. We found that sketching assessment most often employs metrics on accuracy, perspective, line quality, annotations, and aesthetics. Most collected studies examined beginners in undergraduate engineering design sketching or drawing ability tests. Cognitive skills included perceiving the sketch subject, creatively sketching ideas, using metacognition to monitor the sketching process, and using sketching for communication.ImplicationsSketching assessment varies by engineering discipline and relies on many types of feedback and scoring metrics. Cognitive theory can inform instructional activities as a foundation for sketching skills. There is a need for robust evidence of high‐quality assessment practices in sketching instruction. Assessment experts can apply their knowledge toward improving sketching assessment development, implementation, and validation.
Impact of apoptotic biomarkers for prognosis of dengue disease severity among eastern Indian patients
Authors: Sengupta Siddhartha , Manna Srijan , Saha Bibhuti , Tripathi Anusri 
Published: October 2023

AbstractDengue virus (DENV) induced severe manifestations is a precursor for fatality among infected patients. Previous autopsy examinations of severe dengue (SD) patients reported presence of apoptotic cells in liver, brain, intestinal and lung tissues. Thus, serum‐level of major apoptotic proteins of dengue patients was evaluated in the current study, along with their biochemical parameters. Patients were categorized according to World Health Organization (WHO)‐defined classification. DENV‐infection was screened among 165 symptomatic patients by quantitative reverse transcription polymerase chain reaction, antidengue IgM, and IgG ELISA. Serum levels of apoptotic (Capase‐3,7,8, Bcl‐2 and FasL) and hepatic‐markers, lipid profile, hematological parameters of 78 dengue‐positive patients were determined by sandwich‐ELISA/immunoturbidimetry/auto‐analyzer. Significantly higher levels of caspase‐3,7,8 and FasL was detected among SD patients compared to those without warning (WOW) signs. Amongst biochemical parameters, bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase serum concentrations significantly increased among severe patients. Principal component analysis followed by hierarchical clustering differentiated severe and with warning dengue patient groups from those WOW using caspase‐3,7,8 and FasL biomarkers—thus clearly distinguishing severe‐dengue group. Correlation analyses also established strong positive correlation between caspase‐3,7,8 and FasL. Thus, serum level of caspase‐3,7,8 and FasL during early stage of infection could be used as biomarkers for WHO‐defined dengue disease severity.
A spacer design strategy for CRISPR‐Cas12f1 with single‐nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens
Authors: Gao Panqi , Yang Maoyi , Chen Yi , Yan Jun , Han Miaomiao , Deng Haijun , Qian Keli , Yang Jiandong , Lu Yaoqin , Zhou Ling , Huang Ailong , Li Xiaosong , Deng Wanyan , Long Quanxin 
Published: October 2023

AbstractInfectious diseases remain a major global issue in public health. It is important to develop rapid, sensitive, and accurate diagnostic methods to detect pathogens and their mutations. Cas12f1 is an exceptionally compact RNA‐guided nuclease and have the potential to fulfill the clinical needs. Based on the interaction between crRNA‐SSDNA binary sequence and Cas12f1, here, we addressed the essential features that determine the recognition ability of CRISPR‐Cas12f1 single‐nucleotide polymorphism (SNP), such as the length of spacer region and the base pairing region that determines the trans‐cleavage of ssDNA. A fine‐tuning spacer design strategy is also proposed to enhance the SNP recognition capability of CRISPR‐Cas12f1. The optimized spacer confers the Cas12f1 system a strong SNP identification capability for viral or bacterial drug‐resistance mutations, with a specificity ratio ranging from 19.63 to 110.20 and an admirable sensitivity up to 100 copy/μL. Together, the spacer screening and CRISPR‐Cas12f1 based SNP identification method, is sensitive and versatile, and will have a wide application prospect in pathogen DNA mutation diagnosis and other mutation profiling.
The Role of Ultrasound Semi‐Quantitative Scoring in the Diagnosis and Assessment of Gout and Hyperuricemia
Authors: Shao Qin , Wang Jing 
Published: October 2023

ObjectivesTo develop an ultrasound semi‐quantitative scoring system for the diagnosis and evaluation of gout and hyperuricemia.MethodsThis study included 348 male patients: 81 patients with asymptomatic hyperuricemia, 182 patients with gout, and 85 patients with other arthritis. Clinical data were collected, ultrasound was detected, gout activity score was calculated to assess disease activity, and statistical analysis was performed.ResultsMonosodium urate crystal deposition and subclinical arthritis were detected in 17 patients with asymptomatic hyperuricemia, with lesions concentrated in the metatarsophalangeal joint, ankle and peroneus‐longus and brevis at rate of 91.8%. Gout was significantly higher than non‐gouty arthritis in crystal scores (sum scores of double contour, aggregates, and tophi), but not in inflammation scores (sum scores of synovial hypertrophy, power Doppler [PD] activity, and tenosynovitis) and bone erosion. The optimal cut‐off score for the diagnosis of gout by the crystal score was 2. The sensitivity, specificity, and AUC were 95.4%, 97.1%, and .965, respectively. Gout flare had higher inflammation scores than intercritical gout, while bone erosion scores were lower than intercritical gout. The active gout patients had higher ultrasound scores of tophi, bone erosion, and PD activity than the remission group (P < .001). The sensitivity, specificity and area under the receiver operating characteristic curve (AUC) for the identification with high disease activity gout by ultrasound semi‐quantitative composite score were 76.2%, 84.2%, and .812, respectively.ConclusionUltrasound helps early identification of patients at risk in asymptomatic hyperuricemia. Ultrasound semi‐quantitative scoring allows for more objective and accurate assessment of gout lesions, correlates with disease activity, and helps in the diagnosis and assessment of gout.