bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transoral traumatic perforation of the pyriform sinus by a marker pen: report of an infant case
Authors: Oyachi Noboru , Numano Fuminori , Saito Tomohiro , Hoshiai Minako , Koizumi Keiichi 
Published: November 2023

Abstract
Background
Perforation of the pyriform sinus, included in hypopharyngeal injury, is a rare condition typically caused by iatrogenic factors. We present a case of an infant who developed deep cervical and mediastinal abscesses due to a traumatic pyriform sinus perforation caused by accidentally falling with a marker pen in the mouth.

Case presentation
An 11-month-old healthy male infant fell on a trampoline with a marker pen in his mouth. The patient developed swelling in the neck 3 h after the incident and was taken to a regional general hospital. Although a laryngoscopy showed no perforation in the oral cavity or posterior pharynx, a computed tomography (CT) scan revealed significant emphysema extending from the cervix to the mediastinum. The patient was transferred to our tertiary hospital and admitted to the intensive care unit, where he was mechanically ventilated, and antibiotic therapy was initiated. On day 3 of admission, a CT scan revealed deep abscesses in the cervical and upper posterior mediastinum with pneumomediastinum. Although his respiratory status stabilized and he was temporarily weaned, the fever recurred. Pharyngoesopagography revealed significant leakage of contrast from the left pyriform sinus to the mediastinum. Consequently, surgical drainage of the abscess was performed on day 10. Two low-pressure continuous suction drains were placed, one in the posterior mediastinum and the other close to the pyriform sinus. Pharyngoesophagography on postoperative day (POD) 7 demonstrated decreased contrast leakage into the posterior mediastinum. The patient was initiated on enteral nutrition through a nasogastric tube. The patient was discharged on POD 31 after the suction drains were replaced with open Penrose drains, and enteral nutrition via nasogastric tube was continued at home. The Penrose drains were removed on POD 54, and salivary leakage ceased on POD 111.

Conclusions
Although injuries to the oral cavity and posterior pharynx are more easily recognized, the existence of injury in the pyriform sinus can be challenging to evaluate. However, prompt and appropriate management, including intubation, antibiotic therapy, surgical drainage, and nutritional support, is critical in preventing life-threatening complications.
Ocular manifestations and diagnosis of tuberculosis involving the uvea: a case series
Authors: Tsui Jennifer KS , Poon Stephanie Hiu Ling , Fung Nicholas Siu Kay 
Published: November 2023

Abstract
Background
Ocular tuberculosis (TB) affects 1–2% of patients with TB, with TB uveitis being the most common. This series aims to look at different manifestations of tuberculosis associated uveitis and the different tests used to make a presumptive or definitive diagnosis.

Methods
Patients diagnosed with TB related uveitis in Hong Kong SAR between 2017 and 2020 were reviewed. Demographics, clinical features, investigations and treatments of patients were collected.

Results
Fifteen eyes in 10 patients with a mean age 57.30 ± 10.17 years were included. The ocular manifestations on presentation included anterior uveitis (50%), posterior uveitis (40%) and panuveitis (10%), where 70% of them were unilateral and 30% were bilaterally infected; on subsequent visits the manifestations further developed into posterior uveitis (40%), panuveitis (40%) and anterior uveitis (20%), where 50% of them were unilateral and 50% bilateral infected. Tuberculosis tests were positive in 5 out of 7 Mantoux tests, 4 out of 4 T-SPOT TB tests, 3 out of 4 QuantiFERON-TB gold tests, 1 out of 1 lymph node biopsy, 0 out of 9 chest x-rays, and no aqueous fluid polymerase chain reaction (PCR) was tested. Vision impairing complications were seen in 6 patients where retinal vasculitis was most commonly seen. With anti-TB treatment prescribed in 9 patients, side effects occurred in 5 patients, including ocular hypertension, disc swelling, and hepatitis.

Conclusions
Ocular TB infections may manifest in various forms, and can involve different parts of the eye. Bilateral involvement of TB is commonly presented, and both eyes should be evaluated at every follow up. When TB is suspected in a patient, diagnostic confirmation requires multimodal investigations where a negative chest x-ray is not useful in ruling out ocular TB infections, especially in an endemic region like Hong Kong. In these patients, it is crucial to have a high index of suspicion for TB, even when they do not demonstrate classical respiratory signs and symptoms of TB.
Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci
Authors: Yokota Chieko , Fujimoto Kosuke , Yamakawa Natsuko , Kono Masamitsu , Miyaoka Daichi , Shimohigoshi Masaki , Uematsu Miho , Watanabe Miki , Kamei Yukari , Sugimoto Akira , Kawasaki Natsuko , Yabuno Takato , Okamura Tomotaka , Kuroda Eisuke , Hamaguchi Shigeto , Sato Shintaro , Hotomi Muneki , Akeda Yukihiro , Ishii Ken J. , Yasutomi Yasuhiro , Sunami Kishiko , Uematsu Satoshi 
Published: November 2023

Abstract
Background
Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In fact, no vaccines are effective for all pneumococcal serotypes. Fusion pneumococcal surface protein A (PspA) has been shown to induce a broad range of cross-reactivity with clinical isolates and afford cross-protection against pneumococcal challenge in mice. Furthermore, we developed prime-boost-type mucosal vaccines that induce both antigen-specific IgG in serum and antigen-specific IgA in targeted mucosal organs in previous studies. We investigated whether our prime-boost-type immunization with a fusion PspA was effective against pneumococcal infection in mice and cynomolgus macaques.

Methods
C57BL/6 mice were intramuscularly injected with fusion PspA combined with CpG oligodeoxynucleotides and/or curdlan. Six weeks later, PspA was administered intranasally. Blood and bronchoalveolar lavage fluid were collected and antigen-specific IgG and IgA titers were measured. Some mice were given intranasal Streptococcus pneumoniae and the severity of infection was analyzed. Macaques were intramuscularly injected with fusion PspA combined with CpG oligodeoxynucleotides and/or curdlan at week 0 and week 4. Then, 13 or 41 weeks later, PspA was administered intratracheally. Blood and bronchoalveolar lavage fluid were collected and antigen-specific IgG and IgA titers were measured. Some macaques were intranasally administered S. pneumoniae and analyzed for the severity of pneumonia.

Results
Serum samples from mice and macaques injected with antigens in combination with CpG oligodeoxynucleotides and/or curdlan contained antigen-specific IgG. Bronchial samples contained antigen-specific IgA after the fusion PspA boosting. This immunization regimen effectively prevented S. pneumoniae infection.

Conclusions
Prime-boost-type immunization with a fusion PspA prevented S. pneumoniae infection in mice and macaques.
Successful treatment of esophageal perforation due to black esophagus (acute esophageal necrosis): a case report
Authors: Ochiai Takahiro , Takeno Shinsuke , Kawano Fumiaki , Tashiro Kousei , Nanashima Atsushi , Tsuzuki Ryo , Doi Kouichi 
Published: November 2023

Abstract
Background
Black esophagus, or acute esophageal necrosis (AEN), is a rare disease with a poor prognosis in which the esophageal mucosa is black in color. We report a case of esophageal perforation due to AEN that was successfully treated.

Case presentation
An 88-year-old woman presented to her local hospital with the chief complaint of abdominal pain. Endoscopic and radiological examinations revealed esophageal perforation due to AEN and duodenal perforation. Omental patch repair was performed for the esophageal perforation, and the duodenal ulcer perforation was treated by simple closure and gastrojejunostomy at the local hospital. Following refractory esophageal and duodenal perforations after the initial surgery, the patient was transferred to our hospital where emergent surgery was performed, comprising thoracoscopic esophagectomy, cervical esophagostomy, T-tube drainage, and omentopexy for duodenal perforation, as well as thoracic and abdominal drainage. Mucosal regeneration of the esophagostomy was confirmed endoscopically on postoperative day 19.

Conclusions
Appropriate surgical intervention may be an optimal option in patients with esophageal perforation due to AEN.
Numerical simulation and interpretation of sonic arrival times in high-angle wells using the eikonal equation
Authors: Liu Jingxuan , Torres-Verdín Carlos 
Published: November 2023

Unlike the common situation for which vertical wells penetrate horizontal layers, the trajectory of high-angle wells is usually not aligned with the principal axes of elastic rock properties. Borehole sonic measurements acquired in high-angle wells in general do not exhibit axial symmetry in the vicinity of bed boundaries and thin layers, and sonic waveforms remain strongly affected by the corresponding contrast in elastic properties across bed boundaries. The latter conditions often demand sophisticated and time-consuming numerical modeling to reliably interpret borehole sonic measurements into rock elastic properties. The problem is circumvented by implementing the eikonal equation based on the fast marching method to (1) calculate first-arrival times of borehole acoustic waveforms and (2) trace raypaths between sonic transmitters and receivers in high-angle wells. Furthermore, first-arrival times of P and S waves are calculated at different azimuthal receivers included in wireline borehole sonic instruments and are verified against waveforms obtained via 3D finite-difference time-domain simulations. Calculations of traveltimes, wavefronts, and raypaths for challenging synthetic examples with effects due to formation anisotropy and different inclination angles indicate a transition from a head wave to a boundary-induced refracted wave as the borehole sonic instrument moves across bed boundaries. Apparent slownesses obtained from first-arrival times at receivers can be faster or slower than the actual slownesses of rock formations surrounding the borehole, depending on formation dip, azimuth, anisotropy, and bed boundaries. Differences in apparent acoustic slownesses measured by adjacent azimuthal receivers reflect the behavior of wave propagation within the borehole and across bed boundaries and can be used to estimate bed-boundary orientation and anisotropy. The high-frequency approximation of traveltimes obtained with the eikonal equation saves more than 99% of calculation time with acceptable numerical errors, with respect to rigorous time-domain numerical simulation of the wave equation, and is therefore amenable to inversion-based measurement interpretation. Apparent slownesses extracted from acoustic arrival times suggest a potential method for estimating formation elastic properties and inferring boundary geometries.
Highly dispersive solitons in polarization-preserving fibers by Adomian decomposition method
Authors: Asma Mir , Ali A. K. Shafeeque , Alotaibi Abdulaziz , Abolaban Fouad A. 
Published: November 2023

Abstract
This paper numerically studies the existence and characteristics of highly dispersive bright optical solitons in polarization-preserving fibers. The numerical strategy adopted here is the Adomian decomposition method (ADM). The governing model is without self-phase modulation as its influence is negligible. We consider the impacts of group velocity dispersion, third-order dispersions, spatiotemporal dispersion, and nonlinear dispersions on the evolution of bright soliton. We have numerically obtained the bright soliton, which is formed as a result of robust balance among linear and nonlinear temporal as well as spatiotemporal dispersions. To check the accuracy of our numerical results we compare them with the analytical solution. The absolute error is very small and negligible even at large values of propagation time.
The Dangers of Drawing Cohort Profiles From Period Data: A Research Note
Authors: van Raalte Alyson A. , Basellini Ugofilippo , Camarda Carlo Giovanni , Nepomuceno Marília R. , Myrskylä Mikko 
Published: November 2023

Abstract
Drawing cohort profiles and cohort forecasts from grids of age–period data is common practice in demography. In this research note, we (1) show how demographic measures artificially fluctuate when calculated from the diagonals of age–period rates because of timing and cohort-size bias, (2) estimate the magnitude of these biases, and (3) illustrate how prediction intervals for cohort indicators of mortality may become implausible when drawn from Lee–Carter methods and age–period grids. These biases are surprisingly large, even when the cohort profiles are created from single-age, single-year period data. The danger is that we overinterpret deviations from expected trends that were induced by our own data manipulation.
Effects of Preoperative Use of Povidone-Iodine–Impregnated Dressing on Postoperative Rate of Surgical Site Infection in Patients Undergoing Posterolateral Lumbar Spinal Fusion Surgery: A Randomized, Nonblinded, Active-Controlled Trial
Authors: Tavanaei Roozbeh , Ashghani Mohammad Nasirzadeh , Ahmadi Pooria , Alizadeh Sajjad , Yazdani Kaveh Oraii , Zali Alireza , Oraee-Yazdani Saeed 
Published: November 2023

BACKGROUND AND OBJECTIVES:
No study has evaluated the efficacy of using preoperative antiseptic dressings in reducing the rate of surgical site infection (SSI) in spine surgery thus far. To investigate the efficacy of the use of preoperative povidone-iodine–impregnated antiseptic dressings in patients undergoing instrumented posterolateral lumbar spinal fusion.

METHODS:
This was a randomized, nonblinded, active-controlled, parallel-group clinical trial. Patients were randomly assigned to the 2 study groups, including treatment and control. Patients in the treatment group received povidone-iodine–impregnated antiseptic dressing applied to the anticipated incision site 12 hours before the operation. The control group merely received the standard perioperative care with no additional intervention or placebo. Patients were followed up for 90 days, and SSIs were recorded.

RESULTS:
A total of 200 patients were included in this study (100 in each arm). Three cases of SSI were observed in the treatment group compared with 12 in the control one. A significant reduction in the postoperative rate of SSI was observed in the treatment group compared with the control one (P = .029). In addition to study intervention (P = .029), body mass index (P = .005), smoking status (P = .005), duration of the procedure (P = .003), American Society of Anesthesiologists class (P = .002), and diabetes mellitus (P < .001) were significantly associated with the postoperative rate of SSI.

CONCLUSION:
To the best of our knowledge, this study for the first time showed that preoperative use of antiseptic dressings is significantly effective in reducing the rate of SSI in instrumented posterior lumbar spinal fusion surgery. Future studies are warranted to evaluate the efficacy of different preparations or the effectiveness of the present one in patients undergoing spine procedures with other surgical characteristics.
APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway
Authors: Zhu Jun-yi , Lee Jin-Gu , Fu Yulong , van de Leemput Joyce , Ray Patricio E. , Han Zhe 
Published: November 2023

ABSTRACT
People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 and APOL1-G2 risk alleles affect these cells through similar mechanisms. Previously, we have developed transgenic Drosophila melanogaster lines expressing either the human APOL1 reference allele (G0) or APOL1-G1 specifically in nephrocytes, the cells homologous to mammalian podocytes. We have found that nephrocytes that expressed the APOL1-G1 risk allele display accelerated cell death, in a manner similar to that of cultured human podocytes and APOL1 transgenic mouse models. Here, to compare how the APOL1-G1 and APOL1-G2 risk alleles affect the structure and function of nephrocytes in vivo, we generated nephrocyte-specific transgenic flies that either expressed the APOL1-G2 or both G1 and G2 (G1G2) risk alleles on the same allele. We found that APOL1-G2- and APOL1-G1G2-expressing nephrocytes developed more severe changes in autophagic pathways, acidification of organelles and the structure of the slit diaphragm, compared to G1-expressing nephrocytes, leading to their premature death. We conclude that both risk alleles affect similar key cell trafficking pathways, leading to reduced autophagy and suggesting new therapeutic targets to prevent APOL1 kidney diseases.
Should Gig Platforms Decentralize Dispute Resolution?
Authors: Lee Wee Kiat , Cui Yao 
Published: November 2023

Problem definition: Disputes on online labor platforms have traditionally been mediated by the platform itself, which is often viewed as unhelpful or biased. However, there are emerging platforms that promise to resolve disputes with a novel tribunal system and relegate dispute resolution to individual platform users through a voting mechanism. We aim to examine the dispute resolution systems used by traditional platforms (i.e., the centralized dispute system) and emerging platforms (i.e., the decentralized dispute system) in order to assess whether the latter has an advantage over the former. Methodology/results: We use game theory to analyze both the centralized and decentralized dispute systems, and we model the tribunal’s voting game using the global games framework. Our findings indicate that in order to achieve a fair voting outcome, it is crucial to have sufficient heterogeneity in the assessments of tribunal members. Moreover, the decentralized dispute system outperforms the centralized dispute system only when the freelancer’s skill level is sufficiently high. Lastly, the decentralized dispute system has the potential to induce a more socially optimal quality level from the freelancer. Managerial implications: Our findings provide insights on the optimal adoption and implementation of the decentralized dispute system. The decentralized dispute system is more effective for tasks that involve subjective evaluations, and platforms should avoid strategies that homogenize the assessments of tribunal members. Moreover, platforms should consider switching to the decentralized dispute system only if they are able to verify the skill level of freelancers through certification or other means. Lastly, the decentralized dispute system may be more appealing to policy makers because of its potential to induce a more socially optimal outcome. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0398 .
Clinical study of NFNC in the treatment of acute exacerbation chronic obstructive pulmonary disease patients with respiratory failure
Authors: Chen Xiang , Dai Ling , Ma Jin-Zhu , Chu Xin-Xu , Dai Liang , Liu Jian-Ming , Guo Si-Wei , Ru Xin-Wei , Zhuang Xue-Shi 
Published: November 2023

BACKGROUND
Most patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) have respiratory failure that necessitates active correction and the improvement of oxygenation is particularly important during treatment. High flow nasal cannula (HFNC) oxygen therapy is a non-invasive respiratory aid that is widely used in the clinic that improves oxygenation state, reduces dead space ventilation and breathing effort, protects the loss of cilia in the airways, and improves patient comfort.
AIM
To compare HFNC and non-invasive positive pressure ventilation in the treatment of patients with AECOPD.
METHODS
Eighty AECOPD patients were included in the study. The patients were in the intensive care department of our hospital from October 2019 to October 2021. The patients were divided into the control and treatment groups according to the different treatment methods with 40 patients in each group. Differences in patient comfort, blood gas analysis and infection indices were analyzed between the two groups.
RESULTS
After treatment, symptoms including nasal, throat and chest discomfort were significantly lower in the treatment group compared to the control group on the 3rd and 5th days (P < 0.05). Before treatment, the PaO2, PaO2/FiO2, PaCO2, and SaO2 in the two groups of patients were not significantly different (P > 0.05). After treatment, the same indicators were significantly improved in both patient groups but had improved more in the treatment group compared to the control group (P < 0.05). After treatment, the white blood cell count, and the levels of C-reactive protein and calcitonin in patients in the treatment group were significantly higher compared to patients in the control group (P < 0.05).
CONCLUSION
HFNC treatment can improve the ventilation of AECOPD patients whilst also improving patient comfort, and reducing complications. HFNC is a clinically valuable technique for the treatment of AECOPD.
Analysis of the effectiveness of cognitive rehabilitation for patients with chronic mental illness: A meta-analysis
Authors: Jang Jong-Sik , Oh Seri , Kim Geonwoo , Lee Narae , Song Hyesu , Park Jihye , Lee Yushin , Kim Minji , Kwon Mihwa 
Published: November 2023

BACKGROUND
People suffering from chronic mental illness are sensitive to stressful stimuli, lack coping skills, and have low self-esteem due to problems such as social situations. They also experience depression, isolation, fear, and frustration. Due to cognitive dysfunction, people suffering from chronic mental illness have inadequate cognitive processes that lead to distorted thinking.
AIM
To confirm the effectiveness of cognitive rehabilitation therapy in improving cognitive function and alleviating behavioral and psychological symptoms in patients with chronic mental illness, and to identify the cognitive function that had the main effect.
METHODS
The quality of the studies was evaluated using the Assessment of Multiple Systematic Reviews criteria, and data published from 2011 to December 2022 were searched using PubMed, Cochrane, RISS, KISS, and DBpia. The keywords used in the search were “mental illness,” “cognitive rehabilitation,” “cognition,” and “mental.” A meta-analysis was conducted on the 12 selected papers.
RESULTS
The level of evidence for the 12 documents was that of a randomized experimental study. Intervention types in cognitive rehabilitation can be divided into cognitive behavior, cognitive training, cognitive rehabilitation, and computerized cognitive programs. Most of the studies were on schizophrenia, and the measurement areas were cognitive functions (e.g ., concentration, memory, and executive function) as well as depression, sociability, and quality of life. As a result of the meta-analysis of each variable, the effect size for cognitive rehabilitation treatment was in the following order: Sociability, memory, concentration, executive function, quality of life, and depression. Particularly, sociability and memory exhibited significant effects.
CONCLUSION
Cognitive rehabilitation aids cognitive function and sociability in patients with chronic mental illness and can be used as evidence for cognitive rehabilitation in mental health and occupational therapy.