bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal methanogen overgrowth (IMO) is associated with delayed small bowel and colonic transit time (TT) on the wireless motility capsule (WMC)
Authors: Talamantes Sarah , Steiner Faye , Spencer Sean , Neshatian Leila , Sonu Irene 
Published: February 2024

Abstract

Background
Methanogens are associated with gut dysmotility in animal models but have not been robustly studied in humans. The WMC assesses regional transit (TT) and pH in the GI tract.
Aims
To study the segmental TT and pH among patients with SIBO or IMO utilizing WMC.
Methods
We conducted a retrospective study of 207 patients who underwent a glucose or lactulose BT and WMC from 2010–2022. Diagnosis of SIBO and IMO were based on the 2017 North American consensus criteria. TT and pH were extracted from WMC recordings. We tested for differences in means of continuous variables and frequencies of categorical variables using two-sample t-tests, Chi-square, and Fisher exact tests. We used R version 3.3.1 (2016-06-21) for all statistical analyses.
Results
A total of 196 patients met criteria, mean age 47.4 years, 155 (79.1%) females. Of the 86 (43.9%) patients with SIBO, 42 (58.3%) had only IMO and 30 (34.9%) met both hydrogen and methane criteria for SIBO. Small bowel TT was longer in patients with IMO compared to negative patients (5h:49min vs 4hr:49min, p = 0.029). Colonic TT was longer in patients with SIBO compared to negative patients (48h:32min vs 39h:25min, p = 0.050). There were no significant differences in segmental pH compared to negative patients.
Conclusions
To our knowledge, this is the largest study of patients who have undergone BT and WMC. SIBO was associated with delayed CTT and IMO with delayed SBTT, but neither with pH. Future investigation is needed to elucidate whether changes in intestinal microbiota affect gut transit.
Research on Historical Value Evaluation and Protection Strategies of Traditional Courtyards in Yulin Ancient City, Shaanxi Province, China
Authors: Ge Xin , Chen Yang , Wang Lu , Chen Yirui 
Published: February 2024

Abstract
Historic towns and traditional houses are an important part of architectural heritage. Heritage has a dual dimension of time and space, the time dimension reflects "historic", the space dimension expresses "regional", is the core value of urban cultural inheritance and sustainable development. At present, most studies on the preservation and renewal of ancient cities are mainly evaluated from the material space or historical dimension, weakening the value analysis from the full cycle time dimension, while the value evaluation system is mainly divided from the material space and weakens the time dimension. At the same time, most of the research focuses on the historical dimension of time, but the present use and future development are often ignored. Therefore, this paper analyzes the value dimension of the whole cycle, uses the literature analysis method to obtain the evaluation content and indicators, adopts the survey questionnaire and surveying and mapping method to evaluate the quantitative value, establishes the historical value evaluation system, and puts forward the classification principle of the historical value of traditional houses and the corresponding protection strategy. In addition, the paper analyzes the use status and space requirements of traditional courtyards, and summarizes the transformation strategies of use value and sustainable value. Finally, a whole-cycle value assessment framework of the ancient city and residential courtyards was formed, protection and renewal strategies were proposed, and case transformation was carried out to provide reference for historical and regional protection in the development of ancient city heritage.
On a Semi-analytical Method for Solution of the 2d Laplace Equation in Arbitrary Domains
Authors: Kelly David Matthew , Roberts Keith , Kurum Onur 
Published: February 2024

Abstract
This study presents a semi-analytical approach to solve the Laplace equation in arbitrarily shaped two-dimensional domains. The method is meshless and addresses boundary value problems that include both pure Dirichlet and mixed Dirichlet-Neumann boundary conditions. The solution is obtained via a weighted superposition of harmonic polynomials which are obtained via an orthonormalization approach. We show that the approach is efficient in terms of number of operations. The numerical solution is convergent and exact (within machine precision) given a sufficient number of terms in the series. Moreover, the method offers several advantages over traditional approaches. Advantages include providing analytical expressions for the stream function and velocity components when solving potential flow problems. There are also important implications for the storage of model results; the method offers extremely low cost data storage. In the paper, several example applications involving arbitrary domains are presented. The results obtained are compared with known analytical solutions.
Genome-Wide Identification and Characterization of Lipases from Ascomycetes, and Molecular Docking Analysis with Various Plastics
Authors: Amjad Khadija , Shah Tariq , Khan Zeeshan , Haider Ghulam , Sheikh Zeeshan , Adnan Fazal , Bhatti Muhammad Faraz 
Published: February 2024

Abstract
The widespread utilization and inadequate management of plastic products have contributed to a significant increase of microplastics (MPs) in natural environments. MPs persist in the environment and are resistant to degradation. However, certain microorganisms possess the ability to degrade them. This study focuses on the in silico identification and molecular docking analysis of different lipases found in various fungal species, specifically aiming to assess their catalytic potential for microplastic degradation. In addition to observing enzyme-substrate interactions at the active site, hydrophobic interactions, highest binding affinity and hydrogen bonds were also examined. A total of 71 lipases were identified from 13 fungal species on the basis of presence of the lipase 3 domain. Most of the proteins were predicted to be extracellularly localized. Based on the results of molecular dockings, in terms of binding affinities, polycarbonate (PC) was found to have the highest binding affinities with all the docked proteins which suggests that it is the most biodegradable plastic type. However, polyvinyl chloride (PVC) exhibited low binding energies with all the lipases indicating its resistance against degradation via fungal lipases. Key amino acids involved in binding interactions of PC were found to be glycine, alanine and valine. The binding interactions encompass hydrogen bonding, Van der Waals forces and Pi-interactions. These findings highlighted the potential of enzymes sourced from fungal species for microplastic degradation purposes. The role of lipase in the germination of A. oryzae was also predicted under soy sauce koji fermentation. It was found that 4 proteins were upregulated whereas 4 proteins were downregulated.
PLPP2 as a metabolic and immune marker for predicting survival and enhancing response to anti-PD1 therapy in pancreatic cancer
Authors: Sheng Guannan , Du Xiaoyan , Ni Bo , Liu Ziyun , Wu Chenyan , Meng Kewei , Xie Yongjie , Yang Tao 
Published: February 2024

Abstract
Objective
The aim of this study was to establish genetic markers based on metabolic, stromal, and immune factors by analyzing pancreatic cancer (PC) transcriptome datasets to predict prognosis and response to PD-1 therapy in patients with PC.
Methods
We used the pancreatic cancer data set from the TCGA database to identify metabolic-related genetic markers through statistical analysis of artificial intelligence technology. The association between these markers and overall survival (OS) in PC patients was then analyzed. Metabolism, stroma, and immunity were evaluated using GSEA and EPIC algorithms. Finally, external validation was performed on the GEO data set.
Results
PLPP2 was found to be associated with PC metabolism and can effectively predict OS and disease-free survival. Internal verification confirms the accuracy of the mark. PLPP2 was also found to be involved in the metabolism of tumor cells and to regulate the immune system. PLPP2 was evaluated based on clinical relevance, metabolic relevance, immune landscape, and immune checkpoint therapy potential. In vivo experiments showed the potential of PLPP2 as a marker for predicting metabolic status, immune landscape, and response to immune checkpoint inhibitors in PC patients.
Conclusion
PLPP2 is a newly identified marker that predicts stromal, metabolic, and immune features in PC. These findings have potential applications in therapeutic strategies, particularly in the context of immune checkpoint blocking. This study provides crucial insights into the molecular mechanisms of PC, genetic markers that predict prognosis and treatment response, and guides personalized treatment and improved patient outcomes.
Solid Lubrication Performance of Hybrid Ti3C2Tx/MoS2 Coatings
Authors: Boidi Guido , Zambrano Dario , Schwarz Sabine , Marquis Edoardo , Varga Markus , Ripoll Manel Rodríguez , Badisch Ewald , Righi Maria Clelia , Gachot Carsten , Grützmacher Philipp G. , Rosenkranz Andreas 
Published: February 2024

Abstract
MXenes have gained notable attention in tribology due to their excellent wear resistance based on the formation of beneficial tribofilms. However, studies using MXenes as solid lubricants have mainly focused on multi-layer Ti3C2Tx coatings, while little is known about the tribological performance of MXene composites. Therefore, our study aims at scrutinizing and understanding the tribological behavior of MXenes and MXene composites as solid lubricants under reciprocating sliding conditions. Theoretical predictions regarding the resulting interlayer adhesion and coating-substrate adhesion helped to design the hybrid coatings. Multi-layer Ti3C2Tx, molybdenum disulfide (MoS2) and two hybrid coatings using Ti3C2Tx and MoS2 (random mixture and sandwich-like) were spray-coated onto steel substrates with a coating thickness of about 800 nm. Dry sliding tests using a steel ball as counter-body were carried out at room temperature. The coatings’ morphology and formed tribofilms were holistically characterized by scanning and transmission electron microscopy (SEM, TEM) as well as X-ray photoelectron spectroscopy (XPS). Our results demonstrated that both hybrid coatings notably reduced friction and wear, which was traced back to synergic effects between Ti3C2Tx and MoS2 thus enhancing the formation of a stable tribofilm. Consequently, our work demonstrated the potential of Ti3C2Tx/MoS2 hybrid coatings to further optimize friction and wear.
CRISES E PERSPECTIVAS PARA OS OBJECTIVOS DO DESENVOLVIMENTO SUSTENTÁVEL EM MOCAMBIQUE
Authors: Cacilda Maria André Zaqueu Ligia 
Published: February 2024

Este artigo emerge devido ao marco de inicio da agenda, o ano 2020 do qual, coincidi com a eclosão da Covid-19 no mundo, tornando o projeto um desafio. Um Sec. XXI imbuído de guerras resultando em crise global e no contexto em que Moçambique é assolado por intempéries, conflitos partidários, domínio de insurgentes nas províncias do norte de Moçambique, fatores climáticos e dívidas ocultas, todos esses elementos colocam o Governo de Moçambique à prova da integridade política para o cumprimento desta Agenda 30, alinhado aos projetos nacionais: o Plano Quinquenal do Governo, e outros instrumentos nacionais de Planificação. Nesse imbróglio, constitui objetivo geral analisar os mecanismos implantados para o Desenvolvimento Sustentável (ODS), e os objetivos específicos identificar as ações que sustentem a implementação dos ODS; integrando neste processo, a descentralização como instrumento de participação. Para tal, o artigo foi desenvolvido de forma minuciosa, no âmbito de pesquisa bibliográfica nacional e estrangeira, adotando como metodologia a análise documental sobre o assunto e aplicou-se o questionário para 26 gestores nas diferentes Direções do distrito, dos quais só 05 responderam e dois devolveram alegando não ter o domínio dos planos da Agenda 30, levando a crer na necessidade de formação do gestores naquele distrito sobre a matéria de ODS, Ainda, constatou-se no estudo que, as crises internas e externas têm abalado os diferentes Municípios, neste caso antes da pesquisa o Município, era distrito de Marracuene até novembro de 2022.Mesmo assim envidando esforços para contornar as crises globais.
“EU SOU A BRANQUINHA DO PAPAI”
Authors: Santos Mariana dos Reis 
Published: February 2024

Esta pesquisa procurou evidenciar um relato de experiência de uma professora e pesquisadora dentro de uma instituição especializada em deficiência visual (DV). O estudo enfatizou a interseccionalidade de “gênero”, “raça” e “DV” como elementos a serem abordados em duas rodas de conversas versando sobre os temas “A condição da mulher e violência93 na nossa sociedade” e “Racismo e escravidão”. A ausência destas temáticas no cotidiano destes educandos DV tanto no convívio com os familiares como por parte do corpo docente desta instituição evidencia a construção de estereótipos destes sujeitos enquanto passíveis de subjetividade ou dependentes da construção da identidade do “outro”. Sendo assim, a expressão “Eu sou a branquinha do papai” proferida por uma educanda deficiente visual negra em sala de aula revela a ausência de identificação dela com sua própria autodeclaração étnica. Por isso, a metodologia das rodas de conversa adotada levou em consideração os questionamentos e colocações previamente levantados pelos educandos com deficiência visual e a construção do conhecimento a partir de um processo dialógico e aberto. Com isso, constatou-se nas vivências docentes da roda de conversa que embora o assunto de “Gênero e Sexualidade” seja muito provocativo e instigante no coletivo de estudantes e em âmbito individual, as questões de raça e negritude produzem um silenciamento do grupo, reverberando o apagamento das questões curriculares sobre “Raça” num espaço de Educação Especial.
PROJETO ESCOLA SEM HOMOFOBIA E A INVENÇÃO DO “KIT GAY”
Authors: Hilgemberg Larissa Priscila Bredow , Andrade Ana Paula 
Published: February 2024

A proposta deste estudo é compreender o projeto Escola sem Homofobia, sua alcunha “kit gay” e as possíveis heranças à sociedade e educação brasileira tendo como ponto de partida a análise foucaultiana. A partir da diálogo com Foucault, a pesquisa pretende delinear quatro questões relacionadas à invenção do “kit gay”: a primeira é a criação de uma verdade em função das relações de poder para apoiar uma demanda política e social, aliada ao conservadorismo; a segunda, se refere às estratégias de marginalização de sujeitos que não seguem as regras heteronormativas; a terceira é a invenção de um pseudoconceito para barrar a entrada oficial de um tema incômodo – a sexualidade – nas escolas, auxiliando uma estrutura disciplinar historicamente constituída; a quarta questão é o silenciamento não apenas dos sujeitos, mas dos conteúdos e temáticas, transformando o Escola sem Homofobia em “kit gay”.
Who are “the least?” Ἐλάχιστος (Mt 25:31-46) – a hermeneutical reconsideration
Authors: CIUCIU Hrisostom 
Published: February 2024

The present paper deals with the interpretation of one of the Matthean texts that still raises problems to modern exegesis, namely the one relating to the Last Judgment (Mt 25:31-46), and this because of a term – ἐλάχιστος (v. 40) – translated with “the least”. The question to which the author tries an answer is: “Who are the little ones?” The approach of the work is not so much one of an exegetical nature, but it is of a hermeneutical nature. Beyond the difficulties that modern exegesis seems to have failed to overcome, the real challenge is the spiritual interpretation of this text, an interpretation which depends very much on identifying those who are “the least”.
This work attempts to harmonize the textual exegesis with the patristic interpretation, having the stated purpose of applying this text to the spiritual life, both relating to the person and community.
Short-term parenteral infusions with high-osmolality amino acid solutions can be safely administered through peripheral catheters in dogs treated for hypoaminoacidemia-related conditions
Authors: Arsenault Anne C. , Loftus John P. , Rishniw Mark 
Published: February 2024

Abstract

OBJECTIVE
To compare complications between central and peripheral administration of high-osmolarity (approx 700 to 1,000 mOsm/L) amino acid (± lipid) infusions.

ANIMALS
18 client-owned dogs diagnosed with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome or superficial necrolytic dermatitis receiving parenteral amino acid ± lipid infusions.

METHODS
In this retrospective case series, medical records were reviewed for administration route (central vs peripheral), catheter details and infusion characteristics (product osmolarity, concurrent lipid administration, infusion volume, duration, and rate), and complications for each infusion.

RESULTS
18 dogs received 277 infusions (median, 8.5; range, 1 to 84). Effective infusion osmolarities were 683 mOsm/L in 22% of infusions, 791 mOsm/L in 8%, 802 mOsm/L in 2%, 837 mOsm/L in 45%, and 998 mOsm/L in 23% (65% peripheral, 35% central). Most (n = 230 [83%]) infusions were given peripherally. The osmolarities of solutions administered by each route (P = .53), the infusion rate indexed to body weight (P = .17), or the lipid infusion rates indexed to body weight (P = .89) did not differ. One dog suffered 2 complications in 63 infusions—1 mild, 1 severe—both occurring with peripheral infusions. Thus, the overall complication rate was 2 of 277 (0.9%) infusions.

CLINICAL RELEVANCE
Short-term peripherally administered amino acid ± lipid infusions < 1,000 mOsm/L confer little risk compared to centrally administered infusions. Additional studies are needed to determine the safety of infusions with longer durations. Due to the relative ease of peripheral catheterization, clinicians should consider this route for medically managing aminoaciduric canine hypoaminoacidemic hepatopathy syndrome and superficial necrolytic dermatitis in dogs.
A Highly Selective Real-Time Electroanalytical Detection of Sulfide Via Laser-Induced Graphene Sensor
Authors: Singh Ritesh Kumar , Amreen Khairunnisa , Dubey Satish Kumar , Goel Sanket 
Published: February 2024

Abstract
Herein, a novel miniaturized sensor for sulfide detection is presented. The sensor was fabricated over a flexible polyimide substrate via CO2 laser ablation followed by surface modification with methylene blue acting as a redox mediator. The sensor showed an acceptable linear detection range (0.5 μM–1 mM), and excellent limit of detection (0.435 μM) and limit of quantification (2.45 μM). Further, remarkable sensitivity of 0.295 μA/(μM mm2) for 0.5–50 μM and 0.0047 μA/(μM mm2) for 100–1 mM was obtained. The signal-to-noise ratio was found to be 2.76 and the performance was validated by real lake water samples.
Comparison of outlier detection approaches in a Smart Cities sensor data context
Authors: Zafeirelli Sofia , Kavroudakis Dimitris 
Published: February 2024

Abstract
This study examines outlier detection in time-series sensor data from PurpleAir low-cost sensors in Athens, Greece. Focusing on key environmental parameters such as temperature, humidity, and particulate matter (PM) levels, the study utilizes the Interquartile Range (IQR) and Generalized Extreme Studentized Deviate (GESD) methods on hourly and daily basis. GESD detected more outliers than IQR, most of them in PM, while temperature and humidity data had fewer outliers; applying filters before outlier detection and adjusting alpha values based on time scales were crucial, and outliers significantly affected spatial interpolation, emphasizing the need for spatial statistics in smart city air quality management.
Efek Temperatur dan Waktu Terhadap Total Kandungan Antioksida Dari 5 Jenis Tanaman Herbal dengan Metode Phenanthroline Termodifikasi
Authors: Arman Etriyanto , Yefrida Y. , Refinel R. 
Published: February 2024

This research determines the effect of temperature, maceration time, extract storage time at room temperature and refrigerator temperature of the total antioxidant content in miana leaves (Plectranthus scutellarioides (L.)R. Br), papaya leaves (Carica papaya), rambutan leaves (Nephelium lappaceum), bay leaves (Eugenia polyantha) and green betel leaves (Piper betel L). The determination of total antioxidant content was carried out by modified phenanthroline method. Based on the research data. It was found that the optimum conditions for total antioxidant content in the samples above were at 100oC with 60 minutes of maceration time and without storage time of the extracted samples before being analyzed. The total antioxidant content of miana leaves, papaya leaves, rambutan leaves, bay leaves, and green betel leaves analyzed in the optimum conditions are 3.0865; 1.1554; 0.4641; 0.6764; and 3.3630 mmol Fe/g DW, respectively.
أثر القيادة التشاركية في تعزيز روحانية مكان العمل دراسة تحليلية لآراء عينة من العاملين في دائرة صحة نينوى
Authors: شويت العلي محمد ظاهر , أحمد ميسون عبدالله 
Published: February 2024

يهدف البحث الحالي إلى التعرف على الأثر الذي تحدثه القيادة التشاركية بأبعادها (تفويض السلطة، المشاركة في اتخاذ القرار، العلاقات الانسانية، والاتصال وبناء المعلومات) في روحانية مكان العمل بأبعادها (العمل الهادف، الاحساس بالمجموعة، الملاءمة بين قيم الفرد والمنظمة، والاستغراق الوظيفي) في المنظمة المبحوثة. تم وضع مخطط افتراضي يوضح الباحثان من خلاله طبيعة العلاقات بين متغيري البحث المستقل والتابع، ولتحقيق أهداف البحث تم الاعتماد على استمارة الاستبانة بوصفها الأداة الرئيسة في جمع بيانات الجانب الميداني للدراسة، إذ تم تصميم الاستبانة بواقع (49) فقرة غطت كل أبعاد البحث. فيما يتعلق بميدان البحث فقد تم اختيار (دائرة صحة نينوى) بوصفها ميدانا للدراسة، وتم استقصاء آراء عينة يبلغ حجمها (407) مبحوث من دائرة صحة نينوى بكافة اقسامها. واعتمد الباحثان على عدد من الأساليب الإحصائية لتحليل بيانات الجانب الميداني باستخدام (AMOS. V24)، توصل الباحثان بعد اختبار الفرضيات الموضوعة التي اجابت على المشاكل البحثية إلى عدد من الاستنتاجات أهمها نتائج التحليل الإحصائي للمعادلة البنائية وأظهرت النمذجة (SEM) تأثيرًا كبيرًا لمتغير القيادة التشاركية على متغير الروحانية في مكان العمل، مما يشير إلى أن أبعاد القيادة التشاركية تساهم بشكل مباشر في إظهار أبعاد الروحانية في مكان العمل بين الأفراد العاملين في المنظمة التي تم فحصها. في ضوء الاستنتاجات المقدمة قدم الباحثان مجموعة من التوصيات أبرزها استغلال كل ما يؤدي إلى روحانية أعلى في مكان العمل، وعليه يتطلب استخدام مفاهيم القيادة التشاركية في المنظمة التي يتم التحقيق فيها بشكل يسهم في رفع المستوى من الروحانية في مكان العمل.