bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Cardiac Dysfunctions in Patients with Liver Cirrhosis Admitted in a Tertiary Care Centre
Authors: Kasthuri Ramachandran Pillai  , Selvarajan Chettiar K. P.  , Suresh M. K.  
Published: November 2023

BACKGROUND
The presence of cardiovascular dysfunction in liver cirrhosis has been studied over the past several years. Cardiovascular dysfunctions in cirrhosis increase the risk of coronary artery disease and mortality after TIPSS insertion and liver transplantation. Cirrhotic cardiomyopathy also plays an important role in the pathogenesis of hepatorenal syndrome. All these data highlight the need for rigorous cardiovascular risk assessment in patients with liver cirrhosis.
METHODS
After obtaining institutional approval, we analysed 96 consenting patients with liver cirrhosis satisfying inclusion criteria. Relevant history of the cases was sought through a structured questionnaire. Appropriate clinical examinations were done. Echocardiogram, ECG and biochemical parameters of the patients were examined and recorded. Data analysis was done using SPSS software.
RESULTS
51% of the patients had QTc > 0.44 seconds in ECG which was suggestive of electrophysiological abnormality. The systolic dysfunction was assessed by presence of left ventricular ejection fraction below 55%, which was detected in 4.2% of the patients. E/A ratio less than 1 and deceleration time more than 200 msec were taken as parameters suggestive of the presence of diastolic dysfunction. 34.4% had an E/A ratio < 1 and 42.7% of the patients had a deceleration time more than 200 msec. 53% were found to have cirrhotic cardiomyopathy. The prevalence of CCM was increasing with the severity of liver disease. 53.1% of the patients had left ventricular hypertrophy and there was significant association between the prevalence of LVH and severity of cirrhosis. 38.5% of the patients had coronary artery disease as per history and ECG findings. No significant association was obtained between the prevalence of CAD and severity of CLD. 4.2% patients had arrhythmia and there was a significant association with the severity of disease. Troponin I was elevated in 20.8% of the patients.
CONCLUSIONS
Liver cirrhosis is a risk factor for cardiovascular dysfunctions. Most of the patients with cardiac compromise were asymptomatic. 53% patients were diagnosed to have cirrhotic cardiomyopathy. The prevalence of cardiovascular dysfunctions was found to increase with the rising severity of cirrhosis as per CTP score. Diastolic dysfunction was more prevalent than systolic dysfunction. The prevalence of cardiovascular dysfunctions was lesser among patients with regular follow-up and treatment for cirrhosis liver. 38.5% of the patients had coronary artery disease. The prevalence of arrhythmias was 4.2%. Troponin levels were elevated in 20.8% patients.
PENTINGNYA SIKAP BIJAK DALAM BERMEDIA SOSIAL
Authors: Sudarsih Sri , Widisuseno Iriyanto 
Published: November 2023

Pengabdian masyarakat ini konsentrasi pada urgensi sikap bijaksana dalam menggunakan media sosial bagi pengemudi becak pariwisata di Yogyakarta. Media sosial merupakan salah satu media yang dapat menunjang pengembangan pariwisata di Yogyakarta. Metode yang digunakan dalam pengabdian masyarakat ini adalah sosialisasi dan diskusi interaktif. Sosialisasi ditujukan agar para pengemudi becak memahami mengenai sikap bijak dalam bermedia sosial. Diskusi interaktif bertujuan agar lebih mudah memahami materi dan realisasinya dalam masyarakat. Media sosial merupakan suatu sarana yang dapat dimanfaatkan untuk sarana berkomunikasi. Sikap bijak bermedia sosial yang seharusnya ditunjukkan oleh pengemudi becak adalah media sosial seharusnya menjadikan seseorang semakin memahami makna hidupnya, mampu menyelesaikan persoalan hidupnya dengan bijaksana, memahami orang lain dengan berempati, dan mengedepankan integritas, sikap dan tingkah lakunya selalu mencerminkan nilai-nilai etika yang mendasari setiap aspek hidupnya. Integritas harus dijaga karena menentukan kualitas seseorang. Kata kunci: bijak, media sosial, pariwisata, pengemudi becak This community service focuses on the urgency of being wise in using social media for tourist pedicab drivers in Yogyakarta. Social media is one of the media that can support tourism development in Yogyakarta. The methods used in this community service are socialization and interactive discussions. The outreach is intended so that pedicab drivers understand wise attitudes in using social media. The interactive discussion aims to make it easier to understand the material and its realization in society. Social media is a tool that can be used as a means of communication. The wise attitude in using social media that should be shown by rickshaw drivers is that social media should make a person understand the meaning of his life more, be able to solve his life problems wisely, understand other people with empathy, and prioritize integrity, his attitudes and behavior always reflect the underlying ethical values. every aspect of his life. Integrity must be maintained because it determines a person's quality.Keywords: wise, social media, tourist, rickshaw driver
Optimised feature selection-driven convolutional neural network using gray level co-occurrence matrix for detection of cervical cancer
Authors: Sudhakar K. , Saravanan D. , Hariharan G. , Sanaj M. S. , Kumar Santosh , Shaik Maznu , Gonzales Jose Luis Arias , Aurangzeb Khursheed 
Published: November 2023

Abstract
Cervical cancer is one of the most dangerous and widespread illnesses afflicting women throughout the globe, particularly in East Africa and South Asia. In industrialised nations, the incidence of cervical cancer has consistently decreased over the past few decades. However, in developing countries, the reduction in incidence has been considerably slower, and in some instances, the incidence has increased. Implementing routine screenings for cervical cancer is something that has to be done to protect the health of women. Cervical cancer is famously difficult to diagnose and cure due to the slow rate at which it spreads and develops into more advanced stages of the disease. Screening for cervical cancer using a Pap smear, more often referred to as a Pap test, has the potential to detect the illness in its earlier stages. For the purpose of selecting features for this article, a gray level co-occurrence matrix (GLCM) technique was used. Following this step, classification is performed with methods such as convolutional neural network (CNN), support vector machine, and auto encoder. According to the findings of this experiment, the GLCM-CNN classifier proved to be the one with the highest degree of precision.
Antibacterial, antifungal, antioxidant, and cytotoxicity activities of the aqueous extract of Syzygium aromaticum-mediated synthesized novel silver nanoparticles
Authors: Muruganandham Moorthy , Al-Otibi Fatimah Oleyan , Alharbi Raedah Ibrahim , Sivasubramanian Kanagasabapathy , Raja Ramalingam Karthik , Velmurugan Palanivel , Basavegowda Nagaraj 
Published: November 2023

Abstract
The synthesis of silver nanoparticles using plant-based materials has seen a surge in recent years. This study used the Syzygium aromaticum (clove) buds extract as a reducing agent for synthesizing silver nanoparticles (Sa-AgNPs). The presence of Sa-AgNPs (440 nm) was confirmed by UV-Vis spectroscopy. The optimization of nanoparticle production with pH, metal ions, and substrate concentration (clove extract) was studied. The transmission electron microscopy analysis revealed that Sa-AgNPs had a size distribution predominantly below the range of 10–100 nm. The investigation of Sa-AgNPs using EDX revealed the presence of an optical absorption silver peak at 3 keV. The involvement of phenolic chemicals and carboxylic acids in stretching O–H, N–O, and C═O bonds, forming Sa-AgNPs has been identified by Fourier transform infrared spectroscopy. Klebsiella pneumoniae and Trichophyton rubrum exhibited a higher inhibition zone of 26 ± 0.48 mm and 21 ± 0.48 mm in antibacterial and antifungal activity, respectively. In the 2,2-diphenyl-1-picrylhydrazyl experiment, at a maximum concentration of 500 μg·mL−1, Sa-AgNPs exhibited a scavenging efficiency of 79.98%. Cytotoxicity was observed in the treated cells due to the presence of biologically synthesized Sa-AgNPs. An IC50 value of 48 μg·mL−1 was determined by treating L929 human fibroblast cells.
SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice
Authors: Hammond Haylee R. , Eans Shainnel O. , Cirino Thomas J. , Ananthan Subramaniam , Jimenez-Torres Ana Catya , Zhu Jun , McLaughlin Jay P. 
Published: November 2023

Abstract

Objectives
HIV-1 Tat (transactivator of transcription) protein disrupts dopaminergic transmission and potentiates the rewarding effects of cocaine. Allosteric modulators of the dopamine transporter (DAT) have been shown to reverse Tat-induced DAT dysfunction. We hypothesized that a novel DAT allosteric modulator, SRI-30827, would counteract Tat-induced potentiation of cocaine reward.

Methods
Doxycycline (Dox)-inducible Tat transgenic (iTat-tg) mice and their G-tg (Tat-null) counterparts were tested in a cocaine conditioned place preference (CPP) paradigm. Mice were treated 14 days with saline, or Dox (100 mg/kg/day, i.p.) to induce Tat protein. Upon induction, mice were place conditioned two days with cocaine (10 mg/kg/day) after a 1-h daily intracerebroventricular (i.c.v.) pretreatment with SRI-30827 (1 nmol) or a vehicle control, and final place preference assessed as a measure of cocaine reward.

Results
Dox-treatment significantly potentiated cocaine-CPP in iTat-tg mice over the response of saline-treated control littermates. SRI-30827 treatment eliminated Tat-induced potentiation without altering normal cocaine-CPP in saline-treated mice. Likewise, SRI-30827 did not alter cocaine-CPP in both saline- and Dox-treated G-tg mice incapable of expressing Tat protein.

Conclusions
These findings add to a growing body of evidence that allosteric modulation of DAT could provide a promising therapeutic intervention for patients with comorbid HIV-1 and cocaine use disorder (CUD).
Mesolithic Occupations During the Boreal Climatic Fluctuations at La Baume de Monthiver (Var, France)
Authors: Ricci Giulia , Audiard Benjamin , Tomasso Antonin , Hoareau Leïla , Julien Marie-Anne , Mologni Carlo , Purdue Louise , Porraz Guillaume 
Published: November 2023

AbstractThe Mesolithic technology in Western Europe depicts the last cultural expressions and adaptations of hunter-gatherers before the adoption of Neolithic agro-pastoral practices. Many questions arise when investigating the timing, nature, and historical significance of the Mesolithic. The development of the Mesolithic culture is usually associated with the onset of milder environmental conditions at the beginning of the Holocene. Hunter-gatherer societies would have adopted new subsistence and territorial strategies in response to environmental changes, which would have consecutively impacted their technological system. This assertion considers the Mesolithic in South-western Europe as one homogeneous phenomenon and eludes the putative role that early Holocene climatic fluctuations may have played in hunter-gatherer organizations. In this study, we aimed at questioning the archaeological variability of the first Mesolithic by taking benefit from new data provided by recent excavations at La Baume de Monthiver (Comps-sur-Artuby, France). La Baume de Monthiver is a small rock shelter located along the Jabron Valley in the southern French pre-Alps. The rock shelter records several Mesolithic occupations documenting Sauveterrian technological traditions. By studying the Baume de Monthiver, we take the opportunity to explore the Sauveterrian in itslongue duréeand address the question of its diachronic variability. In this study, we investigated the M-B′ archaeological assemblage and question its homogeneity at the transition of the 10th- and 9th-millennium cal. BP. Our results document stable technological and subsistence practices before and after the climatic fluctuations at the end of the 10th-millennium cal. BP, supporting the hypothesis of well-adapted Mesolithic societies to the climatic “instability” characterizing the early Holocene.
Wotan’s Biopunk: The Grim(m) German God and His English Bloodsport in Sarban’s The Sound of His Horn
Authors: Winthrop-Young Geoffrey 
Published: November 2023

Abstract
The essay analyzes Sarban’s 1952 novel The Sound of His Horn, one of the first alternate histories to depict a victorious Third Reich. The depiction of the latter is a strange mixture. On the one hand, the novel is a product of its day by presenting a regressive, resolutely anti-modern Nazi Germany headed back into a barbarian past. On the other hand, it anticipates later depictions (both in the alternate history genre as well as in historiography proper) by highlighting the constitutive role of technology and the regime’s inner divisions. The latter results in narrowing the gap between the (British) observer and his (German) environment. I argue that this narrowing can be traced by analyzing both the chief villain Hackelnberg, a figure borrowed from German folklore that Jacob Grimm associated with the Germanic god Wotan, and the key motif of hunting. Second, the narrowing is structurally embedded in the novel by virtue of the fact that the counterfactual Nazi domain is confined to a nested narrative. It may be a mere projection, in which case Hackelnberg’s deadly hunts and English bloodsports are not that far apart.
Strategi Pengembangan Ekowisata Gunung Api Purba Nglanggeran Sebagai Penunjang Pertumbuhan Ekonomi di Gunungkidul Yogyakarta
Authors: Saripurnadinata Ronny 
Published: November 2023

Dari kekayaan alam flora dan kondisi geografis Indonesia memiliki berbagai potensi ekowisata.Salah satu daerah Indonesia yang memiliki destinasi ekowisata yang cukup banyak terdapat di Daerah Istimewa Yogyakarta, tepatnya di Gunungkidul.Ekowisata Gunung Api Purba yang terletak di Desa Nglanggeran termasuk dalam destinasi wisata Gunungkidul yang menjadi bagian dari Gunung Sewu.Banyaknya potensi di Desa Nglanggeran untuk dikembangkan menjadi destinasi pariwisata yang tidak hanya bertujuan pada Gunung api purba saja. Pengelolaan pariwisata dan kurangnya strategi mengakibatkan tidak berkembangnya industri pariwisata khususnya Ekowisata Gunung api purba Nglanggeran. Pengelolaan yang tepat dan informai yang lengkap dapat meningkatkan industri pariwisata dan dapat peningkatkan pertumbuhan perekonomian terutama di Kabupaten Gunungkidul.Maka harus diciptakan ide baru dalam pengembangan Ekowisata.Mengingat masih rendahnya SDM, lapangan usaha berbasis pengelolaan sumberdaya alam, pertanian, kehutanan, perikanan, dan lingkungan hidup khususnya dalam bentuk ekowisata.pentingnya konservasi keanekaragaman hayati dan budaya lokal. Dengan adanya strategi pengembangan ekowisata dapat memberikan pendapatan untuk kegiatan konservasi dan keuntungan ekonomi bagi masyarakat yang tinggal di sekitar lokasi ekowisata Gunung Api Purba Nglanggeran.
Analisis Analisis Pelaksanaan Program Asi Eksklusif di Posyandu
Authors: Harshindy Noviani Ade , Rahardjo Bambang Budi 
Published: November 2023

Latar Belakang: ASI Eksklusif adalah Air Susu Ibu yang diberikan kepada bayi sampai bayi berusia 6 bulan tanpa diberikan makanan dan minuman, kecuali obat dan vitamin. Capaian pemberian ASI Eksklusif di Posyandu adalah 50% dari 80% target Progam ASI Eksklusif. Tujuan penelitian ini yaitu untuk mengatahui sejauhmana pelaksanaan Progam ASI Eksklusif di Posyandu Nusa Indah.
Metode: Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif yang berfokus pada pelaksanaan program ASI Eksklusif di Posyandu Nusa Indah. Instrumen yang digunakan adalah panduan wawancara mendalam, observasi, dan dokumentasi. Teknik analisis data menggunakan 3 langkah yaitu : reduksi data, penyajian data, dan penarikan kesimpulan.
Hasil: Hasil penelitian menunjukkan bahwa pelaksanaan program ASI Eksklusif di Posyandu Nusa Indah belum maksimal, dikarenakan SDM yang kurang dan pelatihan konselor tidak diadakan secara rutin, kurangnya sarana dan prasarana, kegiatan yang dilakukan belum optimal dikarenakan pemberdayaan petugas kurang dan informasi yang tidak merata.
Kesimpulan: Pelaksanaan program ASI Eksklusif di Posyandu Nusa Indah V belum berjalan dengan maksimal, saran untuk posyandu yaitu dengan penambahan petugas program ASI Eksklusif, melengkapi sarana prasarana, adanya penyuluhan dan konseling, dan dapat membentuk kelompok pendukung ASI agar cakupan ASI Eksklusif dapat meningkat.
Faktor yang Berhubungan dengan Kejadian Gizi Lebih dan Obesitas pada Remaja
Authors: Masyitoh Masyitoh , Budiono Irwan 
Published: November 2023

Background: The prevalence of overweight and obesity in adolescents in Kelurahan Pela Mampang, Kecamatan Mampang Prapatan, South Jakarta has increased 31,1%. due to the COVID-19 pandemic. This study aims to analyze the factors that associated with the incidence of overweight and obesity in adolescents. Methods: This research is an observational analytic study conducted in a cross sectional design. The sample used in this study were 62 adolescents in Kelurahan Pela Mampang, Kecamatan Mampang Prapatan, South Jakarta, which were selected by using random sampling technique. Results: The analysis used univariate and bivariate analysis with Chi Square test and alternative test using fisher's test. The result of bivariate analysis showed a relevance between the incidence of overweight and obesity with energy intake, physical activity, frequency consumption of junk food, sleep quality, and frequency of ordering food with online applications (p-value<0,05). While from other variables such as family income the education level of mothers, history of parents with overweight and obesity, time screen, and home quarantine has no connection between the incidence of overweight and obesity (p-value>0,05). Conclusions: Based on this research, it was recommended for adolescents to care about their nutritional status and concern to factors that can affect the incidence of overweight and obesity.
Perilaku Kepatuhan Masyarakat dalam Menerapkan Protokol Kesehatan Covid-19
Authors: Alfiyah Fifi , Santik Yunita Dyah Puspita 
Published: November 2023

Background: The Covid-19 pandemic in Indonesia is a health problem that has not yet ended. Covid-19 cases in Indonesia on 31 May 2022 were 6.054.973 cases. Indonesia ministry of Health informed that SARS-CoV-2 continues to mutate to form new variants. Therefore, efforts are needed to prevent the transmission of Covid-19 through the implementation of the Covid-19 health protocol. The purpose of this studi was to determine the factors related to community adherence in implementing the Covid-19 health protocol in the Karangsari Healthcare Center, Cirebon Regency. Method: This type of research uses an analytical survey with a cross sectional design. The research sampel is 99 respondents, with cluster sampling technique. The instrument used a questionnaire. Data were analyzed by chi square test and logostic regression. Results: The result show that knowledge (P=0,009, RP=1,470) and attitude (P=0,003, RP=1,564) are related to community adherence in implementing the Covid-19 health protocol in the Karangsari Healthcare Center, Cirebon Regency. Conclusion: There is a significant related between knowledge and attitude with adherence in implementing the Covid-19 health protocol. Attitude is the factors that most influence the adherence in implementing the Covid-19 health protocol in the Karangsari Healthcare Center, Cirebon Regency.
Aprendizaje-Servicio en México: Participación solidaria en pro de la equidad de género
Authors: Quiroga Garza Angélica 
Published: November 2023

Con un objetivo de acción solidaria, se involucró a estudiantes de pregrado del curso de nivel avanzado PS3105 Aplicaciones en Psicología Clínica en procesos de investigación-acción sobre violencia de pareja para posteriormente aplicar un programa de intervención orientado al empoderamiento de la mujer. Método. Se realizaron dos estudios con participación de 28 y 30 alumnos, respectivamente. El Estudio 1 fue correlacional, transversal de corte cuantitativo, con mujeres mayores de edad (N=134) con el fin de evaluar el índice y severidad de violencia en pareja, el empoderamiento, la ideología de rol y las actitudes sexistas. El Estudio 2 fue una investigación experimental con diseño de preprueba/posprueba con un solo grupo (N=64) orientado al empoderamiento de la mujer a través del desarrollo de una autoestima realista y positiva con vistas a salir del ciclo de la violencia. Resultados. En el Estudio 1 los casos de violencia se presentaron con 28.6% de frecuencia y 29.3% de severidad. El empoderamiento de la mujer aparece asociado al sexismo ambivalente en tanto que la ideología de rol se relaciona con las actitudes sexistas, no así con la severidad de violencia. Después de la intervención en el Estudio 2, hubo un incremento estadísticamente significativo en la autoestima de las participantes. Discusión. Los estudiantes con fundamento en el método científico estudian situaciones relacionadas con su profesión de manera que en forma innovadora y comprometida, basados en principios de bienestar social, generan conocimiento y aplican la inteligencia humana en la transformación de la realidad.
Liderando Escuelas Justas para la Justicia Social
Authors: Murillo F. Javier , Hernández-Castilla Reyes 
Published: November 2023

Partiendo del concepto de Justicia Social entendido como Redistribución, Reconocimiento y Representación (las tres Rs), en este artículo se justifica la necesidad de que las escuelas que trabajen para la justicia social sean, de forma simultánea, escuelas que aborden en sus procesos de enseñanza temáticas y enfoques que desarrollen una educación en justicia social, y escuelas con una organización y funcionamiento justo (escuelas desde la justicia social). A partir de ahí, se aborda desde investigaciones propias y ajenas cómo son estas escuelas. Los comportamientos y valores de los y las líderes que están el frente de esas escuelas es la temática de la segunda parte del texto: Así se tratan temas como la importancia de soñar, de trabajar por el cambio cultural de la escuela, de potenciar el desarrollo de todos los miembros de la comunidad escolar, de favorecer procesos de enseñanza y aprendizaje justos y en justicia social, de potenciar la creación de comunidades profesionales de aprendizaje, de promover la colaboración entre la escuela y la familia, y de expandir el capital social de los estudiantes.
Elemental analysis of wild Eriocheir sinensis: Determining the geographic origin and human health risk assessment
Authors: Bai Shuyan , Wang Shihui , Qin Dongli , Gao Lei , Hao Qirui , Du Ningning , Wang Peng 
Published: November 2023

Identification of composition characteristics of major and trace elements in wild mitten crabs (Eriocheir sinensis) from different water systems is important for protected geographical indication as well as food quality control and safety. In this study, inductively coupled plasma-mass spectrometry was employed to measure the contents of 23 elements in the muscle samples of wild Eriocheir sinensis from three water systems (Suifenhe, Nanliujiang, and Liaohe). The results of Kruskal–Wallis one-way ANOVA test comparisons revealed that most elements were significantly different in the samples collected from three water systems (P < 0.05). Geographic origin discrimination was achieved using principal component analysis in combination with hierarchical cluster analysis (HCA) and stepwise linear discriminant analysis (S-LDA). The HCA results showed the potential of eight characteristic elements for exploratory hierarchical clustering of the samples from three water systems; however, the clustering effect was unsatisfactory. The discrimination accuracy of S-LDA model for the samples from three water systems and that in cross-validation reached 100%. The health risk assessment further revealed that the normal level consumption of wild Eriocheir sinensis did not pose an appreciable health risk to consumers.