bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scoping Review of Surgical Rehabilitation of Post Intubation Phonatory Insufficiency
Authors: Ferraro Ellen L. , Blunck Conrad K. , Benninger Michael S. , Lorenz Robert R. , Nelson Rebecca Chota , Tierney William S. , Bryson Paul C. 
Published: November 2023

ObjectivesPost intubation phonatory insufficiency (PIPI) or posterior glottic diastasis describes posterior glottic insufficiency (PGI) caused by prolonged intubation causing medial arytenoid ulceration, mucosal scarring, and incomplete cricoarytenoid joint adduction. The purpose of this review is to showcase diagnostic findings, surgical rehabilitation, and gaps in our treatment algorithm of PIPI.Data SourcesEmbase, PubMed, Scopus, Web of Science.Review MethodsTwo independent reviewers completed a systematic search of the literature studying PIPI. Reported intubation history, laryngeal defect, clinical symptoms, surgical intervention, and outcomes were gathered from included studies.ResultsNine studies met our inclusion criteria for full review, (45 patients) all of which were case reports/series. All patients had posterior glottic defects, most commonly loss of medial arytenoid tissue, causing varying degrees of PGI. Eleven patients had vocal fold (VF) immobility or hypomobility. Treatment interventions were observation (1), speech therapy (2), VF or posterior glottic injection augmentation (15), medialization laryngoplasty (4), arytenoid repositioning (6), endoscopic (19) or open (3) posterior cricoid reduction, local mucosal rotation flap (11), or free mucosal graft (2) to fill the glottic defect. Observation, voice therapy, and augmentation or type 1 laryngoplasty failed to improve symptoms. Other surgical techniques improved symptoms with varying outcomes.ConclusionPIPI is a difficult injury to diagnosis and treat. Conservative measures and augmentation/laryngoplasty often fail to fix the PGI. Our review supports symptom improvement with reconstruction of the posterior glottic defect with cricoid reduction or mucosal grafts. Future investigation is needed to better define the diagnosis and successful treatment algorithm. Laryngoscope, 134:2048–2058, 2024
A novel framework to integrate cropland quantity and quality from pixel to county level: Implications for requisition–compensation balance of farmland policy in China
Authors: Hu Qiong , Chen Yunping , Hu Jie , Cai Zhiwen , Wang Zhen , Yin Gaofei , Xu Baodong 
Published: November 2023

AbstractCropland quantity and quality are two important indicators for determining agricultural production. However, few studies integrate them at the pixel level for a comprehensive assessment of food production potential. Consequently, it is hard to evaluate the implementation effectiveness of China's Requisition–Compensation Balance of Farmland (RCBF) policy, which requires balances in cropland quality and quantity for land exploitation. Here, we presented a novel framework to assess the impacts of cropland change on food production potential by combining cropland quantity and quality from pixel to county level. The cropland quantity was defined as cropland gain or loss calculated by 30‐m land cover datasets, while cropland quality was characterized by the integration of climate, terrain, and soil factors using a fuzzy comprehensive evaluation method. Then, nine distinct patterns, reflecting the interdependence between changed cropland area and production potential, were identified to represent the implementation effectiveness of RCBF policy for each county. Results showed cropland area decreased by 1.85% during 2005–2015 in Hubei Province, which mainly occurred in regions with moisture climate and very flat terrain. A majority of croplands with the best soil fertility remained relatively stable during this period. The pattern “more occupation than compensation” was the dominant way of implementing RCBF in Hubei. Four counties positively responded to RCBF, for which the compensatory croplands had superior quality than occupied croplands. This study presented an efficient way to evaluate the impacts of cropland change on agricultural production potential, which provides valuable insights for researchers and decision‐makers to strengthen practices and improve policies for land reclamation and consolidation.
A descriptive analysis of otolaryngology presence on the social media platform TikTok
Authors: Olsson Sofia Eva , Schmitz Jonah Francis , Huang Alice Elaine , Murray Alan Douglas 
Published: November 2023

AbstractObjectiveIn recent years, the video sharing app TikTok has become a new venue for health care providers and medical educators. Research on health care information within the app has primarily focused on cosmetic and plastic surgery content. TikTok could potentially be a tool used to educate the public on otolaryngology‐related topics. This study is the first to analyze the quality and quantity of otolaryngology‐related TikTok content.MethodsA cross‐sectional study of TikTok accounts using otolaryngology‐related hashtags within the preceding 6 months was conducted on February 4, 2023. Deductive qualitative analysis was performed between two coders to identify themes of the accounts and their content.ResultsA total of 47 accounts were selected for analysis. Facial plastic surgery was the most represented specialty (n = 20; 43%) and pediatric otolaryngology the least represented (n = 1; 2%). Content posted was primarily educational in nature (n = 30; 64%) and 66% (n = 31) of content creators advertised contact information in their account biography. The majority of accounts were in English (n = 30; 64%) and originated in the United States (n = 30; 64%). More accounts were run by male (n = 29; 62%) than female content creators.ConclusionOtolaryngology is a broad specialty with unequal representation of the related subspecialties on TikTok, a popular social media platform. The majority of current content focuses on patient education in facial plastic surgery. Future studies are warranted to examine the potential growth and impact of otolaryngology content on this video‐based platform.Level of Evidence2.
Graphene Oxides as Epsilon‐Near‐Zero Platforms Operating in Terahertz Frequency Range
Authors: Jun Seung Won , Yim Jong Hyuk , Park Ji‐Yong , Lee Soonil , Ahn Yeong Hwan 
Published: November 2023

AbstractEpsilon‐near‐zero (ENZ) materials, with their unique light manipulation capabilities, have fascinating applications such as cloaking, super‐resolution imaging, energy harvesting, and sensing. Herein, free‐standing graphene oxide films are fabricated whose dielectric constant can be engineered by thermal reduction, resulting in ENZ characteristics at the transition between insulating and metallic phases. The ENZ frequency is found to be 0.4–0.5 THz under an annealing temperature of 200 °C, whereas another ENZ phase appeared at 360 °C. ENZ film can be transferred to curved metal surfaces, serving as superabsorbers that suppress wave reflection from underneath metal surfaces. Hyper‐resolution in nondestructive THz imaging is also possible, owing to superior beaming. Spatial resolution is improved two‐fold by adding the ENZ film, even when the metal pattern is enclosed by a paint layer. Lastly, hybrid sensors are developed by incorporating the meta‐pattern on the free‐standing ENZ substrate. The energy splitting of metamaterial resonance originating from the coupling with ENZ mode is observed. Hybridized devices have proven effective in detecting microorganisms with a low refractive index, owing to the unique dielectric configuration offered by ENZ material. Using the novel ENZ platform, a 15‐fold improvement in microbial sensitivity is achieved compared with the conventional sensors.
Blood‐derived product therapies for SARS‐CoV‐2 infection and long COVID
Authors: Wu Junzheng , Yang Huichuan , Yu Ding , Yang Xiaoming 
Published: November 2023

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is capable of large‐scale transmission and has caused the coronavirus disease 2019 (COVID‐19) pandemic. Patients with COVID‐19 may experience persistent long‐term health issues, known as long COVID. Both acute SARS‐CoV‐2 infection and long COVID have resulted in persistent negative impacts on global public health. The effective application and development of blood‐derived products are important strategies to combat the serious damage caused by COVID‐19. Since the emergence of COVID‐19, various blood‐derived products that target or do not target SARS‐CoV‐2 have been investigated for therapeutic applications. SARS‐CoV‐2‐targeting blood‐derived products, including COVID‐19 convalescent plasma, COVID‐19 hyperimmune globulin, and recombinant anti‐SARS‐CoV‐2 neutralizing immunoglobulin G, are virus‐targeting and can provide immediate control of viral infection in the short term. Non‐SARS‐CoV‐2‐targeting blood‐derived products, including intravenous immunoglobulin and human serum albumin exhibit anti‐inflammatory, immunomodulatory, antioxidant, and anticoagulatory properties. Rational use of these products can be beneficial to patients with SARS‐CoV‐2 infection or long COVID. With evidence accumulated since the pandemic began, we here summarize the progress of blood‐derived product therapies for COVID‐19, discuss the effective methods and scenarios regarding these therapies, and provide guidance and suggestions for clinical treatment.
Delirium due to Trousseau syndrome treated with memantine and perospirone: A case report
Authors: Yamaguchi Junji , Hirayama Takatoshi , Sadahiro Ryoichi , Nakahara Rika , Matsuoka Hiromichi 
Published: November 2023

AbstractBackgroundTrousseau syndrome is a hypercoagulability syndrome associated with cancer. It is known that delirium occasionally occurs after the onset of Trousseau syndrome. However, there have been no detailed reports about treatment for psychiatric symptoms of delirium associated with Trousseau syndrome.Case PresentationA 61‐year‐old man with lung cancer was hospitalized due to Trousseau syndrome. Delirium occurred after hospitalization and psychiatric symptoms worsened. Although haloperidol, risperidone, and chlorpromazine were used, severe insomnia persisted. After memantine (5 mg/day) was used with perospirone, the patient's psychiatric symptoms gradually decreased; he could sleep for 4–5 h at night. Due to psychiatric improvement, he was able to return home and resume immunotherapy for lung cancer as scheduled.ConclusionWe report the first case of Trousseau syndrome delirium treated by memantine used with perospirone. Although further studies are needed, memantine and perospirone might be candidates for the management of psychiatric symptoms associated with Trousseau syndrome.
Population pharmacokinetic and exposure‐response analyses of pemigatinib in patients with advanced solid tumors including cholangiocarcinoma
Authors: Gong Xiaohua , Akil Ayman , Ndi Andre , Ji Tao , Liu Xiang , Lovern Mark , Chen Xuejun 
Published: November 2023

AbstractPemigatinib is a selective, potent, oral inhibitor of fibroblast growth factor receptor (FGFR)1–3 with efficacy in patients with previously treated, advanced/metastatic cholangiocarcinoma (CCA) with FGFR2 alterations. A previously developed population pharmacokinetic (PK) model of pemigatinib was refined using an updated dataset with 467 participants from seven clinical studies, including patients with CCA. Updated PK model parameters were used to evaluate the association between pemigatinib exposure and efficacy and safety. Pemigatinib PK was adequately described by a two‐compartment model with linear elimination and sequential zero‐ and first‐order absorption. The final model successfully minimized, had a successful covariance step, and showed unbiased goodness‐of‐fit. Estimated first‐order absorption rate constant and apparent clearance were 3.7/h and 10.7 L/h, respectively. Sex, baseline body weight, and concomitant use of phosphate binders, proton pump inhibitors, or histamine‐2 antagonists significantly impacted PK parameters; however, the impact of covariates on PK exposure was not clinically significant. Steady‐state pemigatinib exposure and mean change from baseline in serum phosphate concentration were associated with objective response rate in a bell‐shaped relationship and were significantly associated with increased hyperphosphatemia. Pemigatinib exposure was associated with treatment‐emergent adverse events, such as decreased appetite, nausea, and stomatitis, although the relationships were shallow. Overall, analyses indicate that 13.5 mg pemigatinib once daily in 21‐day cycles (2 weeks on, 1 week off) offers a favorable benefit–risk profile in patients with advanced/metastatic or surgically unresectable CCA and is the optimal dose for clinical development.
HaploCatcher: An R package for prediction of haplotypes
Authors: Winn Zachary James , Hudson‐Arns Emily , Hammers Mikayla , DeWitt Noah , Lyerly Jeanette , Bai Guihua , St. Amand Paul , Nachappa Punya , Haley Scott , Mason Richard Esten 
Published: November 2023

AbstractWheat (Triticum aestivum L.) is crucial to global food security but is often threatened by diseases, pests, and environmental stresses. Wheat‐stem sawfly (Cephus cinctus Norton) poses a major threat to food security in the United States, and solid‐stem varieties, which carry the stem‐solidness locus (Sst1), are the main source of genetic resistance against sawfly. Marker‐assisted selection uses molecular markers to identify lines possessing beneficial haplotypes, like that of the Sst1 locus. In this study, an R package titled “HaploCatcher” was developed to predict specific haplotypes of interest in genome‐wide genotyped lines. A training population of 1056 lines genotyped for the Sst1 locus, known to confer stem solidness, and genome‐wide markers was curated to make predictions of the Sst1 haplotypes for 292 lines from the Colorado State University wheat breeding program. Predicted Sst1 haplotypes were compared to marker‐derived haplotypes. Our results indicated that the training set was substantially predictive, with kappa scores of 0.83 for k‐nearest neighbors and 0.88 for random forest models. Forward validation on newly developed breeding lines demonstrated that a random forest model, trained on the total available training data, had comparable accuracy between forward and cross‐validation. Estimated group means of lines classified by haplotypes from PCR‐derived markers and predictive modeling did not significantly differ. The HaploCatcher package is freely available and may be utilized by breeding programs, using their own training populations, to predict haplotypes for whole‐genome sequenced early generation material.
Enhancing thermal stability, mechanical properties, and flammability of polyvinyl alcohol using amide‐functionalized hydrogel and zinc oxide nanoparticles
Authors: Hajibeygi Mohsen , Moradi Hesam , Vahabi Henri 
Published: November 2023

AbstractNew polyvinyl alcohol (PVA) nanocomposites containing zinc oxide (ZnO) nanoparticles and a hydrogel were prepared by the solution casting method. ZnO nanoparticles grafted co‐polymer (Zn‐g‐CP) was synthesized through the reaction of ZnO nanoparticles with vinyltriethoxysilane and then the radical co‐polymerization with 2‐acrylamido‐2‐methylpropane sulfonic acid (AMPS). The amide functionalized hydrogel was prepared via an in situ polymerization of acrylamide and N,N′‐methylene bisacrylamide (MBA) as a crosslinker in a solution of PVA. The corresponding results indicated that the simultaneous presence of both Zn‐g‐CP and hydrogel could significantly increase flammability, thermal stability, and the tensile strength of PVA. The results of the X‐ray diffraction (XRD) and field‐emission scanning electron microscopy (FE‐SEM) indicated a uniform dispersion of ZnO nanoparticles and an enhanced compatibility with the PVA matrix. Thermogravimetric analysis (TGA) in both N2 and air atmospheres, indicated that the temperature at 50% mass loss and the char residue values of PVA nanocomposite containing 6 wt% of Zn‐g‐CP in the presence of hydrogel (PZH12 sample) were enhanced, which was evident by the increased thermal decomposition temperature. The peak of heat release rate (pHRR) value of the PZH12 sample was obtained 56.9% lower than that of the neat PVA demonstrating a significant improvement in flammability behavior. Also, the flame‐retardant performance of PZH12 improved, as compared to the pure PVA, with UL‐94 V1 rating and LOI of 27.2%. The tensile strength (Ts) and elongation at break (EB) values for the mentioned sample enhanced by 62.5% and 7.2% compared to those of the neat PVA, respectively.Highlights
Preparation of vinyl functionalized ZnO nanoparticles (VZnO).
ZnO grafted co‐polymer (Zn‐g‐CP) from a radical polymerization on the VZnO surface.
Preparation of an amide‐sulfonated hydrogel in the PVA solution.
The effect investigation of hydrogel and Zn‐g‐CP on the PVA properties.
The results exhibited the enhanced flame retardancy and mechanical properties of PVA.
Theories of Growth, Innovation, and Entrepreneurship
Authors: Braunerhjelm Pontus , Henrekson Magnus 
Published: November 2023

AbstractOne of the most important—and most difficult—areas of research in economics concerns the mechanisms that cause higher growth and increased prosperity. Economists base their work on theoretical models that are expected to capture the complex relationships of real-world behavior. Policy conclusions are then derived from these simplified models. However, if a model is based on incorrect or over-simplified assumptions, these conclusions will likely prove to be just as flawed.
Conclusions: A Framework for Innovation Policy
Authors: Braunerhjelm Pontus , Henrekson Magnus 
Published: November 2023

AbstractIn the previous chapters, we have discussed the future challenges faced by the European welfare states, in particular Sweden. We have also presented the theoretical and empirical foundations for a restructuring of innovation policies in order to handle an uncertain and demanding future. The issue at stake is how well-equipped countries will cope with a novel competitive landscape, characterized by transformations to abate and adapt to climate change, escalating geopolitical tensions paired with an (as it seems) intensified use of state aid and subsidies, new digitized instruments, and the emergence of platform firms. Even though the world seems to have entered a stage of deglobalization, more and more countries have become integrated into the world economy over the last decades. Several of these countries are resolutely and systematically building up their knowledge bases, with a long-term perspective, increasing their innovation capacity and developing their business sectors. These changed circumstances make innovation imperative and warrant new and distinct policy strategies that strengthen the incentives to engage in risky, often experimental, endeavors to deal with these challenges.
Tactical Urbanism to Develop Cycling Infrastructures: The Implementation of COVID Cycle Lanes in Switzerland
Authors: Widmer Hannah , Guinard Noëlle , Rérat Patrick 
Published: November 2023

AbstractAfter the first COVID-19 wave, the end of the first lockdown represented a window of opportunity to develop vélomobility and to reallocate car space. In this context, Geneva and Lausanne implemented new, pop-up cycle infrastructures that came to be known as ‘COVID cycle lanes’. While such processes were time-specific, local authorities seem to have learned new ways of intervening and experimenting with public spaces in terms of temporary urbanism. It is worth noting, however, that most other Swiss cities did not take such measures. First, this chapter analyses how and why Geneva and Lausanne played tactically with the legal framework in order to implement COVID cycle lanes. We identify the conditions that made such measures possible (urgency, the low quality of existing cycling infrastructures, ‘political champions’, and a desire to develop cycling). We then turn to the way the new cycle lanes were received, including oppositions (mainly from right-wing conservative milieus, car lobbyists, and retailers). Finally, we analyse the reasons for which other cities—such as Lucerne and Zurich—did not implement such measures, despite demands from some local organizations and politicians.
Towards the definition of assembly-oriented modular product architectures: a systematic review
Authors: Monetti Fabio Marco , Maffei Antonio 
Published: November 2023

AbstractThe success of a product in the market is largely defined by the quality of design decisions made during the early stages of development. The product design requires designers to balance multiple objectives such as functionality, cost, and user satisfaction, while addressing the challenges posed by increasing product variants and customization demands. To tackle these challenges, one approach is to structure a comprehensive model that incorporates design for assembly (DFA) guidelines during the formulation of product architecture in the conceptual phase of development. While numerous strategies have been proposed in the literature, information is often scattered, making it difficult for readers to gain a comprehensive understanding of the topic. This paper systematically reviews the role and impact of DFA in product development, consolidating and presenting the information coherently. The review provides an overview of the methods developed, along with their potential benefits and limitations. A common framework is identified that defines the structure of the models, helping designers integrate assembly consideration into their design processes, thus reducing assembly time, cost, and complexity. The framework describes the operational setting, including the domain and context in which models operate, and offers a classification of possible methods and desired outputs. Additionally, the review identifies the industry in which case studies have been most frequently presented, and the software used to facilitate the process. By connecting with such a framework, future models can be created following a structured approach, and existing models can be classified and upgraded accordingly.
The abatement game in a dynamic oligopoly: social welfare versus profits
Authors: Buccella Domenico , Fanti Luciano , Gori Luca , Sodini Mauro 
Published: November 2023

AbstractThis article considers an N-firm oligopoly with abating and non-abating firms and analyses a dynamic setting in which the environmental regulator sets the tax rate to incentivise firms to undertake emission-reduction actions according to different hypotheses (fixed rule and optimal rule). The behaviour of the public authority sharply affects the firm’s (individual) incentive to move towards the abatement activity over time. This changes the number of (non)abating firms on the market and the corresponding social welfare outcomes. The article eventually shows that the environmental policy may cause oscillations resulting in a coexistence of the two types of firms in the long term and pinpoints the welfare outcomes emerging in the model.