bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic description of the FeO–Fe2O3–MgO system and its extrapolation to the X–MgO–FeO–Fe2O3 (X = CaO and SiO2) systems
Authors: Zhang Liang , Liu Yuling , Gao Fengyang , Tan Jing , Yang Lianfeng , Deng Tengfei , Chen Wei , Ouyang Yifang , Du Yong 
Published: January 2024

AbstractThe content of iron oxides has a large impact on the properties of magnesium refractories, knowledge about the thermodynamic equilibria of the FeO–Fe2O3–MgO system is important for the design of refractory materials and resource utilization of solid wastes. The phase equilibria and thermodynamic data of the FeO–Fe2O3–MgO system have been critically evaluated and re‐optimized using the CALPHAD method. The ionic two‐sublattice model (Fe+2, Mg+2)P(O−2, Va, FeO1.5)Q was used to describe the liquid phase. A set of self‐consistent thermodynamic model parameters is presented to describe the phase equilibrium of the FeO–Fe2O3–MgO system. The calculated phase diagrams and thermodynamic properties, employing the optimized model parameters, exhibit excellent agreement with the experimental data. Moreover, the results demonstrate improved consistency when extrapolated to the multicomponent system, such as CaO–MgO–FeO–Fe2O3 and SiO2–MgO–FeO–Fe2O3 systems. The present thermodynamic modeling is useful to construct multicomponent oxide thermodynamic database and to guide the utilization of solid waste resources.
Personal support networks of young people with and without intellectual disability. A comparative study
Authors: Freire Ana Rey , Noell Judit Fullana , Díaz Maria Pallisera 
Published: January 2024

AbstractBackgroundPrevious studies show that the personal support networks of people with intellectual disability are smaller and less diverse than those of people without intellectual disability. This article aims to compare the characteristics of the personal networks of young people with and without intellectual disability.MethodThe Personal Network Analysis (McCarty, Revista Hispana Para El Análisis de Redes Sociales, 2010, 19, 242–271) was applied. The participants comprised 51 young people aged between 13 and 19, of whom 27 had an intellectual disability. The Egonet programme was used to compile information, and SPSS v.27 for the statistical analysis.ResultsYoung people with intellectual disabilities have smaller personal networks than people without disability, while they also comprise more people with disability and fewer ‘friends’ and support people.ConclusionsThe full social inclusion of people with intellectual disability requires schools, families, the community and the individual to work together to develop activities that help them initiate and maintain relationships, prioritising mainstream contexts.
Agenesis of the maxillary permanent lateral incisors with the deciduous retained: Conservative and biomimetic approach using the BAIR technique
Authors: Giachetti Luca , Scaminaci Russo Daniele , Cinelli Francesca 
Published: January 2024

AbstractObjectiveAgenesis of the maxillary permanent lateral incisors is a condition that requires treatment aimed at improving the esthetics, even at an early age. However, traditional therapeutic protocols are long, invasive and have limitations and contraindications imposed by the age of the patient.Clinical ConsiderationsRecent developments in restorative dentistry have provided a new approach to this clinical situation, in particular when the deciduous laterals are retained. We report two cases regarding the management of missing lateral incisors using Biologically Active Intrasulcular Restoration (BAIR) technique. The BAIR technique allows us to transform the shape of the deciduous lateral incisor into the permanent, acting both on the dental morphology and proportions, and on the appearance of the soft tissues and the gingival parables.ConclusionsThe BAIR technique is a valid approach to cases of agenesis of the maxillary permanent lateral incisors, when the deciduous are retained. It does not require any preparation of the dental tissues, is reversible and minimally invasive. It is applicable to patients of all ages, and results are obtained in a single appointment.Clinical SignificanceThe BAIR technique allows a biomimetic conservative approach for the rehabilitation of congenitally missing permanent lateral incisors, when the deciduous are retained. It is a non‐invasive protocol and effective in successfully restoring esthetics.
IbNIEL‐mediated degradation of IbNAC087 regulates jasmonic acid‐dependent salt and drought tolerance in sweet potato
Authors: Li Xu , Wang Zhen , Sun Sifan , Dai Zhuoru , Zhang Jun , Wang Wenbin , Peng Kui , Geng Wenhao , Xia Shuanghong , Liu Qingchang , Zhai Hong , Gao Shaopei , Zhao Ning , Tian Feng , Zhang Huan , He Shaozhen 
Published: January 2024

ABSTRACTSweet potato (Ipomoea batatas [L.] Lam.) is a crucial staple and bioenergy crop. Its abiotic stress tolerance holds significant importance in fully utilizing marginal lands. Transcriptional processes regulate abiotic stress responses, yet the molecular regulatory mechanisms in sweet potato remain unclear. In this study, a NAC (NAM, ATAF1/2, and CUC2) transcription factor, IbNAC087, was identified, which is commonly upregulated in salt‐ and drought‐tolerant germplasms. Overexpression of IbNAC087 increased salt and drought tolerance by increasing jasmonic acid (JA) accumulation and activating reactive oxygen species (ROS) scavenging, whereas silencing this gene resulted in opposite phenotypes. JA‐rich IbNAC087‐OE (overexpression) plants exhibited more stomatal closure than wild‐type (WT) and IbNAC087‐Ri plants under NaCl, polyethylene glycol, and methyl jasmonate treatments. IbNAC087 functions as a nuclear transcriptional activator and directly activates the expression of the key JA biosynthesis‐related genes lipoxygenase (IbLOX) and allene oxide synthase (IbAOS). Moreover, IbNAC087 physically interacted with a RING‐type E3 ubiquitin ligase NAC087‐INTERACTING E3 LIGASE (IbNIEL), negatively regulating salt and drought tolerance in sweet potato. IbNIEL ubiquitinated IbNAC087 to promote 26S proteasome degradation, which weakened its activation on IbLOX and IbAOS. The findings provide insights into the mechanism underlying the IbNIEL‐IbNAC087 module regulation of JA‐dependent salt and drought response in sweet potato and provide candidate genes for improving abiotic stress tolerance in crops.
Electrodiagnostic methods to verify Guillain‐Barré syndrome subtypes in Istanbul: A prospective multicenter study
Authors: Tasdemir Volkan , Sirin Nermin Gorkem , Cakar Arman , Culha Ayla , Soysal Aysun , Elmali Ayse Deniz , Gunduz Aysegul , Arslan Beyza , Yalcin Destina , Atakli Dilek , Orhan Elif Kocasoy , Sanli Elif , Tuzun Erdem , Gozke Eren , Gursoy Esra , Savrun Feray Karaali , Uslu Ferda Ilgen , Aysal Fikret , Durmus Hacer , Bulbul Hafsa , Ertas F. Inci , Uluc Kayihan , Tutkavul Kemal , Baysal Leyla , Baslo Mehmet Baris , Kiziltan Meral , Mercan Metin , Pazarci Nevin , Uzun Nurten , Akan Onur , Cokar Ozlem , Koytak Pinar Kahraman , Sürmeli Reyhan , Gunaydin Sefer , Ayas Selahattin , Baslo Sezin Alpaydin , Yayla Vildan , Yilmaz Vuslat , Parman Yesim , Matur Zeliha , Acar Zeynep Unlusoy , Oge Ali Emre 
Published: January 2024

AbstractBackground and AimsThis study aimed to identify the clinical characteristics and electrodiagnostic subtypes of Guillain‐Barré syndrome (GBS) in Istanbul.MethodsPatients with GBS were prospectively recruited between April 2019 and March 2022 and two electrodiagnostic examinations were performed on each patient. The criteria of Ho et al., Hadden et al., Rajabally et al., and Uncini et al. were compared for the differentiation of demyelinating and axonal subtypes, and their relations with anti‐ganglioside antibodies were analyzed.ResultsOne hundred seventy‐seven patients were included, 69 before the coronavirus disease 2019 pandemic (April 2019–February 2020) and 108 during the pandemic (March 2020–March 2022), without substantial changes in monthly frequencies. As compared with the criteria of Uncini et al., demyelinating GBS subtype diagnosis was more frequent according to the Ho et al. and Hadden et al. criteria (95/162, 58.6% vs. 110/174, 63.2% and 121/174, 69.5%, respectively), and less frequent according to Rajabally et al.'s criteria (76/174, 43.7%). Fourteen patients' diagnoses made using Rajabally et al.'s criteria were shifted to the other subtype with the second electrodiagnostic examination. Of the 106 analyzed patients, 22 had immunoglobulin G anti‐ganglioside antibodies (14 with the axonal subtype). They had less frequent sensory symptoms (54.5% vs. 83.1%, p = 0.009), a more frequent history of previous gastroenteritis (54.5% vs. 22.9%, p = 0.007), and a more severe disease as compared with those without antibodies.InterpretationSerial electrodiagnostic examinations are more helpful for accurate subtype diagnosis of GBS because of the dynamic pathophysiology of the disease. We observed no significant increase in GBS frequency during the pandemic in this metropolis.
Superficial radiotherapy (SRT‐100) for refractory plantar warts: An alternative noninvasive treatment strategy
Authors: Song Ying‐hua , Deng Shuang , Cai Wei‐na , Zhang Liang 
Published: January 2024

AbstractBackgroundVerrucas that occur on the soles of the feet are called plantar warts, most of which can recur repeatedly and are difficult to eradicate. Hypertrophic and refractory plantar warts are often accompanied by pain and discomfort, which cause many inconveniences in patients' daily lives.AimThis study aimed to analyze the therapeutic effect of superficial radiotherapy (SRT‐100) on refractory plantar warts and further create favorable conditions for the subsequent treatment of this disease with a high recurrence rate.MethodsA retrospective analysis was conducted for refractory plantar warts treated with superficial radiotherapy in our outpatient department from January to June 2023.ResultsA total of 30 patients were included in our study (median age, 33 years). The female‐to‐male ratio was 1:3.29. Two to six months after radiotherapy, all of the warts subsided in 23 (76.67%) patients, most of the warts subsided in 4 (13.33%) patients, 3 (10%) patients did not respond to treatment, and 7 (23.33%) patients had recurrent or new warts after their warts subsided.ConclusionsMost patients with refractory plantar warts improved after superficial radiotherapy. Our study presented that men are more susceptible to plantar warts than women, and young and middle‐aged people are the main population affected by the disease. Superficial radiotherapy is an effective treatment for refractory plantar warts, which can quickly remove the warts in a short period. It is safe and noninvasive, with minimal adverse reactions. Some patients relapse after the lesion is clear, and superficial radiotherapy can create favorable conditions for the subsequent treatment of viral warts in clinical practice.
Understanding the impact of chronic diseases on COVID‐19 vaccine hesitancy using propensity score matching: Internet‐based cross‐sectional study
Authors: Miao Yudong , Shen Zhanlei , Li Quanman , Ma Mingze , Xu Dongyang , Tarimo Clifford Silver , Gu Jianqin , Wei Wei , Zhou Xue , Zhao Lipei , Feng Yifei , Wu Jian , Wang Meiyun 
Published: January 2024

AbstractAims and ObjectivesTo investigate whether chronic diseases are associated with higher COVID‐19 vaccine hesitancy and explore factors that influence COVID‐19 vaccine hesitancy in patients with chronic diseases.BackgroundVaccine hesitancy has been acknowledged as one of the greatest hazards to public health. However, little information is available about COVID‐19 vaccine hesitancy among patients with chronic diseases who may be more susceptible to COVID‐19 infection, severe disease or death.MethodsFrom 6 to 9 August 2021, we performed an internet‐based cross‐sectional survey with 22,954 participants (14.78% participants with chronic diseases). Propensity score matching with 1:1 nearest neighbourhood was used to reduce confounding factors between patients with chronic diseases and the general population. Using a multivariable logistic regression model, the factors impacting COVID‐19 vaccine hesitancy were identified among patients with chronic diseases.ResultsBoth before and after propensity score matching, patients with chronic diseases had higher COVID‐19 vaccine hesitancy than the general population. In addition, self‐reported poor health, multiple chronic diseases, lower sociodemographic backgrounds and lower trust in nurses and doctors were associated with COVID‐19 vaccine hesitancy among patients with chronic diseases.ConclusionsPatients with chronic diseases were more hesitant about the COVID‐19 vaccine. Nurses should focus on patients with chronic diseases with poor health conditions, low socioeconomic backgrounds and low trust in the healthcare system.Relevance to Clinical PracticeClinical nurses are recommended to not only pay more attention to the health status and sociodemographic characteristics of patients with chronic diseases but also build trust between nurses and patients by improving service levels and professional capabilities in clinical practice.Patient or Public ContributionPatients or the public were not involved in setting the research question, the outcome measures, or the design or implementation of the study. However, all participants were invited to complete the digital informed consent and questionnaires.
Adoption of evidence‐based end‐of‐life and bereavement support to families in cancer care: A contextual analysis study with health professionals
Authors: Riguzzi Marco , Thaqi Qëndresa , Peng‐Keller Simon , Lorch Anja , Blum David , Naef Rahel 
Published: January 2024

AbstractAimsTo investigate the level of adoption of evidence‐based family engagement and support during end‐of‐life cancer care and subsequent bereavement and its contextual facilitators and barriers from health professionals' perspectives, and to explore differences between professional groups.DesignContextual analysis using an online cross‐sectional survey.MethodsThis study was conducted in four Swiss hospitals and three home care oncology and palliative care services. Non‐parametric testing was used to investigate the level of adoption and differences between nurses, physicians, occupational‐ and physiotherapists and psychosocial professionals (chaplains, onco‐psychologists and social workers). The STROBE checklist for cross‐sectional studies was followed.ResultsThe majority of the 111 participating health professionals were nurses. Adoption was statistically significantly higher during end‐of‐life care than bereavement, with nurses and physicians reporting higher levels than the other professional groups. Guidance on end‐of‐life family care was available in about half of the cases, in contrast to a quarter for bereavement care. Self‐perceived knowledge, skills and attitudes were moderate to high, with nurses and physicians reporting higher levels than others, except for general skills in working with families. Organisational structures were experienced as rather supportive, with the psychosocial group appraising the organisational context as significantly less conducive to fully implementing end‐of‐life and bereavement care than others, particularly during the end‐of‐life phase.ConclusionEvidence‐based family engagement and support were better adopted during end‐of‐life care than bereavement. Overall, nurses and physicians felt better enabled to care for families compared to other professional groups.Patient or Public ContributionNo patient or public contribution.Protocol registrationhttps://osf.io/j4kfh.Implications for the profession and/or patient careImplementation and quality improvement efforts should focus particularly on the bereavement phase and be tailored to professional groups.ImpactThe findings show that evidence‐based family engagement and support practices during end‐of‐life were rather well adopted in contrast to subsequent bereavement care, with nurses and physicians better enabled than other professionals to provide care. A better understanding of health professionals' contributions and roles in family care is important to build interprofessional capacity for evidence‐based end‐of‐life and bereavement support.Reporting MethodThe STROBE checklist for reports of cross‐sectional studies was followed (von Elm et al., 2007).
Older persons' experiences of care encounters in their home: A multiple‐case study
Authors: Gerdin Anna Larsson , Hellzén Ove , Alm Annika Kjällman , Rising Malin Holmström 
Published: January 2024

AbstractAimTo explore and describe older persons' unique experiences of care encounters with home care nurses in a real‐life context.BackgroundThe increasing number of older persons in society contributes to increases in age‐related impairments compromising their quality of life. Future care consists of “hospitals at home” where care encounters occur in a person's private domain, partly becoming a clinical workplace. Scant research has focused on how older persons experience care encounters with home care nurses and needs to be highlighted.DesignMultiple‐case study.MethodsThe cases relied on replication logic and five purposive sampled older persons were interviewed. Data were analysed using qualitative content analysis and differences within and between cases were explored and findings across the cases were replicated.FindingsThe cross‐analysis emerged in three categories: “Nursing routine rules the care encounters”, “Lack of knowledge and information” and “Dependency on support from others”.ConclusionsOur research has found that older persons face challenges while receiving home care, including limited engagement in their care and the need for enhanced support. Implementing person‐centred care in homes poses ethical challenges that require careful consideration. Home care nurses should prioritise understanding each patient individually, recognising them beyond their patient role, which necessitates more thorough and time‐sensitive care encounters.Reporting MethodFindings were reported using COREQ guidelines.Patient or Public ContributionPatients were interviewed and contributed with data for this study.Implications for the Profession and Patient CareThis study emphasises the need to prioritise individualised care in home settings and listen to the voices of older individuals to enhance quality.
Novel insights into metabolic‐associated steatotic liver disease preclinical models
Authors: Montero‐Vallejo Rocío , Maya‐Miles Douglas , Ampuero Javier , Martín Franz , Romero‐Gómez Manuel , Gallego‐Durán Rocío 
Published: January 2024

AbstractMetabolic‐associated steatotic liver disease (MASLD) encompasses a wide spectrum of metabolic conditions associated with an excess of fat accumulation in the liver, ranging from simple hepatic steatosis to cirrhosis and hepatocellular carcinoma. Finding appropriate tools to study its development and progression is essential to address essential unmet therapeutic and staging needs. This review discusses advantages and shortcomings of different dietary, chemical and genetic factors that can be used to mimic this disease and its progression in mice from a hepatic and metabolic point of view. Also, this review will highlight some additional factors and considerations that could have a strong impact on the outcomes of our model to end up providing recommendations and a checklist to facilitate the selection of the appropriate MASLD preclinical model based on clinical aims.
Cost‐effectiveness study of FIB‐4 followed by transient elastography screening strategy for advanced hepatic fibrosis in a NAFLD at‐risk population
Authors: Park Huiyul , Yoon Eileen L. , Kim Mimi , Kwon Sun‐Hong , Kim Donghee , Cheung Ramsey , Kim Hye‐Lin , Jun Dae Won 
Published: January 2024

AbstractBackground & AimsThe cost‐effectiveness to screen hepatic fibrosis in at‐risk population as recommended by several professional societies has been limited. This study aimed to investigate the cost‐effectiveness of this screening strategy in the expanded at‐risk population recently proposed by several societies.MethodsA combined model of the decision tree and Markov models was developed to compare expected costs, quality‐adjusted life‐years (QALYs) and incremental cost‐effectiveness ratio (ICER) between screening and no screening groups. The model included liver disease‐related health states and cardiovascular disease (CVD) states as a base‐case analysis. Screening strategy consisted of fibrosis‐4 index (FIB‐4) followed by vibration‐controlled transient elastography (VCTE) and intensive lifestyle intervention (ILI) as a treatment for diagnosed patients.ResultsCost‐effectiveness analysis showed that screening the at‐risk population entailed $298 incremental costs and an additional 0.0199 QALY per patient compared to no screening (ICER $14 949/QALY). Screening was cost‐effective based on the implicit ICER threshold of $25 000/QALY in Korea. When the effects of ILI on CVD and extrahepatic malignancy were incorporated into the cost‐effectiveness model, the ICER decreased by 0.85 times from the base‐case analysis (ICER $12 749/QALY). In contrast, when only the effects of liver disease were considered in the model, excluding cardiovascular disease effects, ICER increased from the baseline case analysis to $16 305. Even when replacing with medical costs in Japan and U.S., it remained cost‐effective with the estimate below the countries' ICER threshold.ConclusionsOur study provides compelling evidence supporting the cost‐effectiveness of FIB‐4‐based screening the at‐risk population for advanced hepatic fibrosis.
Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants
Authors: Rau Fiona , Elsner Carina , Meister Toni Luise , Gömer André , Kallies René , Dittmer Ulf , Steinmann Eike , Todt Daniel 
Published: January 2024

AbstractHepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency of these variants remains unknown in the human population as well as environment due to limited comprehensive data on HEV diversity. In this study, we investigated the HEV prevalence and diversity of circulating variants in environmental samples, that is, wastewater and rivers from North‐Rhine Westphalia, Germany. HEV prevalence could be determined with 73% of samples tested positive for viral RNA via qRT‐PCR. Using high‐throughput sequencing, we were able to assess the overall genetic diversity in these samples and identified the presence of clinically relevant variants associated with drug resistance. In summary, monitoring variants from environmental samples could provide valuable insights into estimating HEV prevalence and identifying circulating variants that can impact treatment outcome.