bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics of asundexian with combined CYP3A and P‐gp inhibitors and an inducer: Target in vitro and in vivo studies
Authors: Kanefendt Friederike , Brase Christine , Jungmann Natalia , Fricke Robert , Engelen Anna , Schmitz Sebastian 
Published: December 2023

AimsAsundexian is an oral, direct and reversible inhibitor of activated factor XI (FXIa) in development for the treatment of thromboembolic events. This article summarizes results from preclinical and clinical studies, including identification of enzymes involved in asundexian pharmacokinetics, and evaluation of potential target drug–drug interactions.MethodsIn vitro studies investigated the substrate characteristics of asundexian towards several cytochrome P450 (CYP) isoforms, hydrolytic enzymes and drug transporters. Inhibition of the amide hydrolysis of asundexian was investigated in vitro for several relevant drugs. Phase 1 studies in healthy male participants investigated the pharmacokinetics (PK) of asundexian upon co‐administration of combined inhibitors or an inducer of P‐gp and CYP3A4 (itraconazole, verapamil or carbamazepine, respectively, or the moderate CYP3A4 inhibitor fluconazole). The pharmacodynamic (PD) markers are activated partial thromboplastin time and FXIa inhibition.ResultsAsundexian was predominantly metabolized via carboxylesterase 1 and, to a lesser extent, via CYP3A4 and is a substrate of P‐gp. The asundexian area under the plasma concentration–time curve (AUC) increased by 103% and 75.6% upon combined inhibition of P‐gp and strong or moderate inhibition of CYP3A4, respectively, but was unaffected by moderate CYP3A4 inhibition. Combined P‐gp and CYP3A4 induction by carbamazepine decreased asundexian AUC by 44.4%. PD is concentration‐dependent, thus no differences in maximum responses and recovery commensurate with PK effect(s) were observed. Adverse events were mild and asundexian was well tolerated.ConclusionsThe presented studies confirmed that CYP3A4 and P‐gp contribute to asundexian metabolism and excretion. Observed effects were in line with data from a previous mass balance study.
Revisiting the first reported case of aplastic anaemia
Authors: Steensma David P. 
Published: December 2023

SummaryThe great pathologist Paul Ehrlich in Berlin is commonly credited with describing the first clear case of aplastic anaemia in 1888: a 21‐year‐old woman who presented with haemorrhage and signs and symptoms of severe anaemia, quickly succumbing to her illness. Ehrlich's description of this patient's background and clinical course allowed individual identification. Re‐analysis of this case suggests an inherited bone marrow failure syndrome as a possible additional diagnosis.
Control–value appraisals and academic emotions: An intensive longitudinal examination of reciprocal effects
Authors: Chen Xin , Leung Frederick K. S. 
Published: December 2023

AbstractThis study examined the reciprocal relation between lesson‐specific perceived cognitive appraisals and academic emotions on an intra‐individual level. A daily diary study was conducted using a sample of 266 Chinese Han students (Grades 7–8; 56.8% boys; Mage = 13.70, SDage = 0.52) during 10 mathematics lessons in 2022. Standardized questionnaires were also administered to these students before the daily diary study. The results of the dynamic structural equation modeling revealed significant reciprocal relations between cognitive appraisals and academic emotions within early adolescents and highlighted the role of emotions in guiding cognitive appraisals. Additionally, the study identified similarities and differences in the inter‐individual relation between appraisals and emotions across self‐reported questionnaires and daily diary measures.
Interspecific competition between ants and African honeybees (Apis mellifera scutellata) may undermine the effectiveness of elephant beehive–deterrents in Africa
Authors: Thornley Reece , Cook Robin , Spencer Matthew , Parr Catherine L. , Henley Michelle 
Published: December 2023

AbstractBeehive deterrents are commonly used to mitigate human–elephant conflict and protect woody vegetation. To ensure hive activity, reduce abscondment risks, and maintain deterrent effectiveness, resident bee colonies require supplementary feeding during periods of low resource availability. However, our study found that ants frequently consume the supplementary feed in open feeders intended for bees. Anoplolepis custodiens was the most numerically dominant species that excluded bees from the feeders, followed by Camponotus and Crematogaster spp. With higher ant abundance, the predicted probability of zero bees being present at feeders increased up to 82%. This competition may undermine the efficacy of beehive deterrents as a conflict mitigation tool. We developed a simple and effective ant exclusion method that raised the overall predicted probability of bees' presence at supplementary feeding stations from 32% to 68%. Our findings suggest that innovative solutions to exclude ants from supplementary feed may improve the implementation and success of this conflict mitigation method across Africa.
Consecutive decentralization: The effect of central bank independence on capital account liberalization
Authors: Lee Joon Hyeok 
Published: December 2023

AbstractCentral bank independence (CBI) has been widely advocated as a means to address the time‐inconsistency problem of controlling inflation. Consequently, many countries have embraced central bank reforms since the 1990s. While extant research in political science has sought to unveil the consequences of CBI, there remains an unexplained variation in the response of countries with regard to capital account openness. Notably, a positive association exists between CBI and capital account openness due to the constraints CBI places on leaders' discretionary monetary and fiscal policies, thereby fostering reliance on financial policy to boost their economies. However, this relationship is contingent on the domestic political contexts of countries. CBI leads to capital account liberalization only when the rule of law is guaranteed, given that CBI is often stipulated by laws. Therefore, in countries where political leaders can easily override formal rules, CBI shows no discernible impact on capital account openness. Employing two‐way fixed‐effects and error‐correction models, the study reveals that CBI increases capital account openness only in democracies, in the presence of multiple veto players, and a high level of transparency. The findings underscore the pivotal role of the domestic political environment in analyzing how CBI constrains political leaders.
Networked feminism in a digital age—mobilizing vulnerability and reconfiguring feminist politics in digital activism
Authors: Vachhani Sheena J. 
Published: December 2023

AbstractIn what ways can we understand the productive tensions and complexities of digital feminist activism? This paper explores the increase of networked feminism, which focuses attention on digital activism and its relation to transformative social change. It suggests that we need a better understanding of how digital feminist activism might be changing the shape of transnational feminist resistance and praxis, and how feminist politics are created and enacted in digitally mediated environments. These result in new forms of feminist consciousness built on affective and embodied engagements. The paper explores the complex and ambivalent role of affective politics and embodied ethics to explore conditions of vulnerability. Using illustrative, global cases to show the nuances across digital activism, the paper contributes to understanding the complexities and differential effects of online environments, the mediation of feminist politics through digital knowledge cultures and the possibilities, challenges, and productive tensions that lie in the ever‐increasing use of digital environments.
Patterns of gastrointestinal injury in patients with chronic kidney disease: Comparison of cases with and without sevelamer crystals
Authors: Shakeri Hania , Panarelli Nicole C 
Published: December 2023

AimsSevelamer is a phosphate‐binding resin implicated in gastrointestinal (GI) injury. This study aimed to investigate the role of sevelamer in GI injury among chronic kidney disease (CKD) patients.Methods and resultsThe study included 17 CKD patients (cases) with and 18 CKD patients (comparisons) without sevelamer crystals in specimens. All cases were on sevelamer. Six comparison patients were also taking sevelamer, but crystals were absent in tissue sections. The comparison group was thus subclassified into patients who were and were not taking sevelamer. The frequency of underlying disorders was similar between two groups, including hypertension (cases = 82%; comparisons = 78%) and diabetes mellitus (cases = 53%, comparisons = 50%). The most common presentation was GI bleeding (cases = 41%, comparisons = 33%). Predominant histological patterns were also similar, with ulcers (cases = 42%; comparisons = 39%) and acute ischaemia (cases = 35%; comparisons = 28%) being predominant in both cohorts. Of note, sevelamer was present with amyloidosis and cytomegalovirus in one study case each. Two study patients who continued sevelamer had follow‐up biopsies; one showed persistent ulceration and the other appeared normal. Crystals were absent in both.ConclusionsGI injury in CKD patients in both groups had similar features regardless of presence of sevelamer, suggesting that it adheres to tissue rather than causes injury. The study highlights other histologically identifiable causes of intestinal injury, as well as injuries unassociated with sevelamer in patients undergoing therapy. Therefore, physicians should be cautious in attributing GI injuries to sevelamer to avoid overlooking other causes and unnecessary treatment discontinuation.
Mesothelioma in the pleura, pericardium and peritoneum: Recommendations from the International Collaboration on Cancer Reporting (ICCR)
Authors: Klebe Sonja , Judge Meagan , Brcic Luka , Dacic Sanja , Galateau‐Salle Francoise , Nicholson Andrew G , Roggli Victor , Nowak Anna K , Cooper Wendy A 
Published: December 2023

AimsMesothelioma is a rare malignancy of the serosal membranes that is commonly related to exposure to asbestos. Despite extensive research and clinical trials, prognosis to date remains poor. Consistent, comprehensive and reproducible pathology reporting form the basis of all future interventions for an individual patient, but also ensures that meaningful data are collected to identify predictive and prognostic markers.Methods and resultsThis article details the International Collaboration on Cancer Reporting (ICCR) process and the development of the international consensus mesothelioma reporting data set. It describes the ‘core’ and ‘non‐core’ elements to be included in pathology reports for mesothelioma of all sites, inclusive of clinical, macroscopic, microscopic and ancillary testing considerations. An international expert panel consisting of pathologists and a medical oncologist produced a set of data items for biopsy and resection specimens based on a critical review and discussion of current evidence, and in light of the changes in the 2021 WHO Classification of Tumours. The commentary focuses particularly upon new entities such as mesothelioma in situ and provides background on relevant and essential ancillary testing as well as implementation of the new requirement for tumour grading.ConclusionWe recommend widespread and consistent implementation of this data set, which will facilitate accurate reporting and enhance the consistency of data collection, improve the comparison of epidemiological data, support retrospective research and ultimately help to improve clinical outcomes. To this end, all data sets are freely available worldwide on the ICCR website (www.iccr‐cancer.org/data‐sets).
Predicted factors of surgical site infection in glioblastoma patients: A meta‐analysis
Authors: Gu Zhaowen , Wang Qiangwei , Chen Jiarui , Zhu Yongjian 
Published: December 2023

AbstractSurgical site infection (SSI) is one of the common postoperative complications after craniotomy for glioblastoma patients. Previous studies have investigated the risk factors for SSI in patients with glioblastoma. Whereas big differences in research results exist, and the correlation coefficients of different research results are quite different. A meta‐analysis was conducted to examine the risk factors related to surgical site infection in patients with glioblastoma. We searched English databases to collect case–control studies or cohort studies published before 15 October 2023 including PubMed, Web of Science, Embase. The risk of bias of the included studies was assessed via Newcastle‐Ottawa Scale. The analysis was performed using RevMan 5.4.1 tool. A total of 4 articles (n = 2222) were selected in this meta‐analysis. The following risk factors were presented to be correlated with SSI in glioblastoma: irradiation (OR = 1.88, 95% CI [0.46, 7.60]), more than 3 surgeries (OR = 2.99, 95% CI [1.47, 6.08]). Occurrence of SSI is influenced by a variety of factors. Thus, we should pay close attention to high‐risk subjects and take crucial targeted interventions to lower the SSI risk following craniotomy. Owing to the limited quality and quantity of the included studies, more rigorous studies with adequate sample sizes are needed to verify the conclusion.
Adaptive interviewing for the inclusion of people with intellectual disability in qualitative research
Authors: McFarland Bridget , Bryant Lia , Wark Stuart , Morales‐Boyce Tyson 
Published: December 2023

AbstractBackgroundHistorically the voices of people with intellectual disability have been occluded by barriers imposed by research practice. More recently, adaptive research approaches have been proposed to enhance the inclusion of people with intellectual disability in qualitative research.MethodThis article presents an adaptive interviewing approach employed with five people ageing with intellectual disabilities in rural South Australia. The interviews were conducted within a broader participatory action research project in which tools and resources were co‐designed for post‐parental care planning.ResultsWe describe our adaptive interviewing approach incorporating multiple methods: (i) responsive communication techniques; (ii) the inclusion and support of family carers; (iii) visual tools; (iv) walking interviews.ConclusionFindings contribute knowledge about how an adaptive interview approach supports the participation of people with an intellectual disability in qualitative research.
Patient‐reported quality of life and acceptance of the extravascular implantable cardioverter‐defibrillator: Results from pivotal study
Authors: Sears Samuel F. , Harrell Rebecca , Crozier Ian , Murgatroyd Francis , Boersma Lucas V. A. , Manlucu Jaimie , Knight Bradley P. , Leclercq Christophe , Birgersdotter‐Green Ulrika Maria , Wiggenhorn Christopher , Hilleren Gregory , Friedman Paul 
Published: December 2023

AbstractIntroductionThe pivotal study of the extravascular implantable cardioverter‐defibrillator (EV ICD) recently demonstrated primary efficacy and safety endpoints comparable to previous ICD systems. Patient experience with this novel device has not been reported. The current study examined the standardized patient‐reported outcome (PRO) metrics of quality of life (QOL) and patient acceptance of the device.MethodsThe EV ICD Pivotal Study was a prospective, single‐arm, nonrandomized, global, premarket approval trial. Patients completed the 12‐Item Short Form Survey (SF‐12) QOL surveys at baseline and at 6 months following implant. Additionally, patients completed the Florida Patient Acceptance Survey (FPAS) QOL survey at 6 months.ResultsFrom baseline to 6 months, patients within the EV ICD Pivotal Study (n = 247) reported statistically significant SF‐12 improvements in physical QOL (45.4 ± 9.4 vs. 46.8 ± 9.1 respectively, p = .020) and no changes in mental QOL (49.3 ± 10.4 vs. 50.5 ± 9.7, p = .061). No differences were noted by sex, atrial fibrillation, or the experience of ICD shock. EV ICD patients reported better total FPAS patient acceptance of their ICD than TV‐ICD or S‐ICD patients using historical norms comparisons (80.4 ± 15.7 vs. 70.2 ± 17.8, p < .0001 for S‐ICD and 73.0 ± 17.4, p = .004 for TV‐ICD).ConclusionThe initial PROs for EV ICD patients indicated that patients had improvements in physical QOL from baseline to 6‐month follow‐up and markedly better overall acceptance of their ICD compared to a previous study with S‐ICD and TV‐ICD data. These initial results suggest that the EV ICD is evaluated positively by patients.
Board talk: How members of executive hospital boards influence the positioning of nursing in crisis through talk
Authors: Verhoeven Arjan , Marres Henri , van de Loo Erik , Lalleman Pieterbas 
Published: December 2023

AbstractTalk by members of executive hospital boards influences the organizational positioning of nurses. Talk is a relational leadership practice. Using a qualitative‐interpretive design we organized focus group meetings wherein members of executive hospital boards (7), nurses (14), physicians (7), and managers (6), from 15 Dutch hospitals, discussed the organizational positioning of nursing during COVID crisis. We found that members of executive hospital boards consider the positioning of nursing in crisis a task of nurses themselves and not as a collective, interdependent, and/or specific board responsibility. Furthermore, members of executive hospital boards talk about the nursing profession as (1) more practical than strategic, (2) ambiguous in positioning, and (3) distinctive from the medical profession. Such talk seemingly contrasts with the notion of interdependence that highlights how actors depend on each other in interaction. Interdependence is central to collaboration in hospital crises. In this paper, therefore, we depart from the members of executive hospital boards as leader and “positioner,” and focus on talk—as a discursive leadership practice—to illuminate leadership and governance in hospitals in crisis, as social, interdependent processes.
The regeneration conferring transcription factor complex ERF115‐PAT1 coordinates a wound‐induced response in root‐knot nematode induced galls
Authors: Ribeiro Cleberson , de Melo Bruno Paes , Lourenço‐Tessutti Isabela Tristan , Ballesteros Helkin Forero , Ribeiro Karla Veloso Gonçalves , Menuet Killian , Heyman Jefri , Hemerly Adriana , de Sá Maria Fatima Grossi , De Veylder Lieven , de Almeida Engler Janice 
Published: December 2023

Summary
The establishment of root‐knot nematode (RKN; Meloidogyne spp.) induced galls in the plant host roots likely involves a wound‐induced regeneration response. Confocal imaging demonstrates physical stress or injury caused by RKN infection during parasitism in the model host Arabidopsis thaliana.
The ERF115‐PAT1 heterodimeric transcription factor complex plays a recognized role in wound‐induced regeneration. ERF115 and PAT1 expression flanks injured gall cells likely driving mechanisms of wound healing, implying a local reactivation of cell division which is also hypothetically involved in gall genesis.
Herein, functional investigation revealed that ectopic ERF115 expression resulted in premature induction of galls, and callus formation adjacent to the expanding female RKN was seen upon PAT1 upregulation. Smaller galls and less reproduction were observed in ERF115 and PAT1 knockouts. Investigation of components in the ERF115 network upon overexpression and knockdown by qRT‐PCR suggests it contributes to steer gall wound‐sensing and subsequent competence for tissue regeneration. High expression of CYCD6;1 was detected in galls, and WIND1 overexpression resulted in similar ERF115OE gall phenotypes, also showing faster gall induction.
Along these lines, we show that the ERF115‐PAT1 complex likely coordinates stress signalling with tissue healing, keeping the gall functional until maturation and nematode reproduction.
Comparison of the anticancer effects of various statins on canine oral melanoma cells
Authors: Ishikawa Takuro , Irie Nanami , Tashiro Jiro , Osaki Tomohiro , Warita Tomoko , Warita Katsuhiko , Naito Munekazu 
Published: December 2023

AbstractCanine oral melanoma is a highly malignant cancer with a poor prognosis. Statins, commonly used drugs for treating dyslipidemia, exhibit pleiotropic anticancer effects and marked anti‐proliferative effects against melanoma cells. The anticancer effects among statins vary; in human cancers, lipophilic statins have shown stronger anticancer effects compared with hydrophilic statins. However, data on the differences in the effects of various statins on canine cancer cells are lacking, hence the optimal statins for treating canine melanoma remain unknown. Therefore, this study aimed to clarify the most effective statin by comparing the anticancer effects of hydrophilic rosuvastatin and lipophilic atorvastatin, simvastatin, fluvastatin and pitavastatin on three canine oral melanoma cell lines. Time‐dependent measurement of cell confluence showed that lipophilic statins had a stronger anti‐proliferative effect on all cell lines than hydrophilic rosuvastatin. Quantification of lactate dehydrogenase release, an indicator of cytotoxicity, showed that lipophilic statins more effectively induced cell death than hydrophilic rosuvastatin. Lipophilic statins affected both inhibition of cell proliferation and induction of cell death. The anticancer effects of statins on canine oral melanoma cells differed in the following ascending order of IC50 values: pitavastatin < fluvastatin = simvastatin < atorvastatin < rosuvastatin. The required concentration of pitavastatin was approximately 1/20th that of rosuvastatin. Among the statins used in this study, pitavastatin had the highest anticancer effect. Our results suggest lipophilic pitavastatin as the optimal statin for treating canine oral melanoma.
Efficacy of therapeutic plasma exchange in a case of severe, generalised canine pemphigus foliaceus
Authors: Edmonds Kaitlyn Bello , Her Jiwoong , Langston Catherine , Jennings Ryan , Diaz Sandra 
Published: December 2023

AbstractSuccessful treatment of pemphigus foliaceus (PF) often requires a multimodal therapeutic approach. The dog described herein underwent four therapeutic plasma exchange treatments for severe, refractory PF, resulting in a 50% reduction of lesional body surface area. This treatment option should be considered for the management of canine PF.