bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive model of acute heart failure rehospitalization: A retrospective study in Prof. I.G.N.G Ngoerah Hospital
Authors: Nyoman Ririn Chandrika Sari  , Hendy Wirawan  , Rani Paramitha Iswari Maliawan  , IGN Putra Gunadhi  
Published: November 2023

Introduction. Heart failure is one of the main causes of cardiovascular morbidity and mortality. Research stated that heart failure patients who have undergone 3 rehospitalizations have a survival rate of <50% within 1 year. Therefore, the purpose of this study is to characterize the risk factors that contribute to the occurrence of heart failure rehospitalization.
Method. This is a retrospective analysis of 113 patients with a first hospitalization for heart failure at Prof. I.G.N.G. Ngoerah Hospital between July 2018–February 2020. We collected and compared demographic data, clinical findings, electrocardiogram, laboratory, and echocardiography parameters during the first hospitalization between rehospitalized and non-rehospitalized patients. Rehospitalization was defined as recurrent hospital admission due to worsening heart failure symptoms. Patients were followed for rehospitalization events until death or November 2021.
Results. The rehospitalization rate in this study was 62.8% during a median follow-up of 234 days (12–1098 days). The average of heart failure rehospitalizations during follow-up was 1.73 times (±1.97), with an average length of stay of 6.40 days (±3.27 days). We discovered that the presence of mid/apical rales at admission (odds ratio [OR] 3.509; p=0.027), hyponatremia (<135 mmol/L) at pre-discharge (odds ratio [OR] 3.840; p=0.015), and tricuspid annular plane systolic excursion (TAPSE) values <1.80 cm (odds ratio [OR] 2.905; p=0.020) were independent risk factors for rehospitalization due to worsening heart failure symptoms. Patients with these three independent risk factors have a probability of 96.24% being readmitted.
Conclusion. Mid/apical rales at admission, hyponatremia at pre-discharge, and TAPSE values <1.80 cm in patients admitted for heart failure are associated with further rehospitalization.
The association of comorbidities with mortality and severity among children with COVID-19
Authors: Riani Ni Made Dwi Angga , Purniti Ni Putu Siadi , Subanada Ida Bagus 
Published: November 2023

Background: Several case series have described the clinical characteristics of COVID-19 in pediatric patients and suggest milder illness severity in children compared with adults. However, some cases presented more severe diseases with small numbers of deaths have been documented. Some studies in developed countries demonstrated that the presence of comorbidities among COVID-19 patients could increase the severity of the disease. Therefore, this study aimed to identify the association of comorbidities with mortality and severity among children with COVID-19.
Methods: This was an analytic retrospective cross-sectional study conducted in Prof. Dr. IGNG Ngoerah Hospital, Denpasar, from May 2020 until March 2022. A total of 94 children aged 28 days-18 years old with confirmed COVID-19 were included in this study and divided into two groups, with comorbidities and without comorbidities. The chi-square test was used to determine the association between comorbidities and their relation to mortality and severity. The statistical significance was set at p less than 0.05.
Results: The normality test showed that the age data distribution is not normal with the median age of 72 months (IQR 45-189) and 108 months (IQR 64-240) in the comorbidities and without comorbidities group, respectively. Bivariate analysis showed there was a significant association between comorbidities with the mortality and severity among children with COVID-19 (PR 3.21; 95% CI 1.04-9.90; p= 0.036) and (PR 10.71; 95%CI 4.12-27.83; p< 0.001), respectively. The multivariate analysis revealed the comorbidities increased risk of mortality and severity with adjusted OR (aOR) 3.74 (95%CI 1.14-12.25) and adjusted OR (aOR) 11.8 (95%CI 4.35-32.41), respectively; after adjusting for age and nutritional status.
Conclusion: Comorbidities significantly affect mortality and severity among children with COVID-19.
Autologous Serum Eye Drops (ASEDs) as dry eye disease treatment option
Authors: Anak Agung Ayu Putri Oktiadewi  , I Putu Rustama Putra  
Published: November 2023

Background: Nowadays, there are a lot of treatment options available for dry eye syndrome (DES) or disease (DED). Autologous Serum Eye Drops (ASEDs) is one of the options that offer a potential advantage over conventional therapy. Biochemical elements in ASEDs resemble real tears and act as a lacrimal substitute to provide lubrication. As a severe dry eye treatment, using ASEDs has grown in favor.
Aim: This review aims to deliver knowledge from the current literature on applying ASEDs for dry eye disease in the medical worker.
Method: The method used was a literature review. A comprehensive search was performed on Pubmed and Google Scholar databases in December 2022 using each of the following keywords “ASEDs”, “serum”, “eyedrop”, “DED” and “DES”.
Conclusion: Dry eye disease is incurable and symptom management is the focus of therapy. Studies have shown that ASEDs reduced dry eye symptoms in over 60% of patients by inhibiting the release of inflammatory cytokines and increasing the number of goblet cells and mucin expression in the conjunctiva. The serum eye drop is typically well tolerated and can be one of the best treatment options for severe DED due to its close resemblance to tears, preservatives free and minimum side effects.
Hubungan antara riwayat hipersensitivitas dan kadar imunoglobulin e (IgE) total serum dengan sindrom koroner akut di unit pelayanan jantung terpadu RSUP sanglah denpasar
Authors: Mataram Kadek Wisnu , Suryana Ketut , Aryadana Wayan 
Published: November 2023

Background: Currently, mast cells are implicated in the pathogenesis of coronary heart disease. Mast cells are the only cell tissue that expresses on the surface of the high affinity receptor for IgE (FCεR) and synthesizes vasoactive, spasmogenic, fibrogenic factors and can damage the connective tissue covering the atheroma plaque so that the plaque is prone to rupture. The aim of this study was to determine the relationship between a history of hypersensitivity and total serum IgE levels with acute coronary syndrome.
Methods: This study was an analytic cross-sectional study to determine the relationship between history of hypersensitivity and total serum IgE levels with acute coronary syndrome. The study was conducted at the Integrated Cardiac Service Unit Sanglah Hospital Denpasar with consecutive sampling according to the inclusion and exclusion criteria of 68 samples.
Results: The results of the history of hypersensitivity analysis with ACS obtained a p value of 0.685; OR 0.778. Analysis of the relationship between total serum IgE levels and ACS resulted in a p value of 0.000; OR 10.385, a history of hypersensitivity with IMA obtained a p value of 0.187; OR 0.281 and total IgE levels with IMA obtained a p value of 0.584; OR 0.273.
Conclusion: There is a relationship between total serum Immunoglobulin E (IgE) levels with acute coronary syndrome and MI. There is no relationship between history of hypersensitivity with acute coronary syndrome or MI.

Latar Belakang: Saat ini, sel mast diimplikasikan dalam patogenesis dari penyakit jantung koroner. Sel mast merupakan satu-satunya jaringan sel yang ekpresinya pada permukaan high affinity receptor untuk IgE (FCεR) dan mensintesis faktor vasoaktif, spasmogenik , fibrogenik dan dapat merusak jaringan ikat yang menutupi plak atheroma sehingga plak rentan pecah. Tujuan Penelitian ini untuk mengetahui hubungan antara riwayat hipersensitivitas dan kadar IgE total serum dengan sindrom koroner akut.
Metode: Penelitian ini merupakan penelitian dengan rancangan potong lintang analitik untuk mengetahui hubungan antara riwayat hipersensitivitas dan kadar IgE total serum dengan sindrom koroner akut. Penelitian dilakukan di Unit Pelayanan Jantung Terpadu RSUP Sanglah Denpasar dengan consecutive sampling sesuai kriteria inklusi dan eksklusi sebesar 68 sampel.
Hasil: Hasil analisis riwayat hipersensitivitas dengan SKA didapatkan nilai p 0,685; OR 0,778. Analisis hubungan antara kadar IgE total serum drngan SKA didapatkan hasil nilai p 0,000; OR 10,385, riwayat hipersensitivitas dengan IMA didapatkan nilai p 0,187;OR 0,281 serta kadar IgE total dengan IMA didapatkan hasil nilai p 0,584; OR 0,273.
Simpulan: Terdapat hubungan antara kadar Immunoglobulin E (IgE) total serum dengan sindrom koroner akut dengan IMA. Tidak terdapat hubungan antara riwayat hipersensitivitas dengan sindom koroner akut maupun IMA.
Tatalaksana kasus trombosis vena dalam iliofemoral akut dengan sistem trombektomi aspirasi mekanik Indigo CAT8
Authors: Wiradana Anak Agung Gde Agung Anom Arie , Wibawa I Gusti Agung Bagus Krisna , Budiarta Ida Bagus 
Published: November 2023

Introduction: Acute deep vein thrombosis is a common cause of morbidity and mortality. Venous thrombosis commonly involves the lower extremities, including the iliac veins, femoral veins and vena cava. Optimal therapy of deep vein thrombosis, both ileofemoral and central can prevent complications.
Case Presentation: A 51 years old man complained of swelling of his right leg accompanied by acute pain. On duplex ultrasonography examination, there was a venous thrombosis in the iliofemoral area descending from the common iliac vein to the deep femoral vein. Endovascular venous mechanical thrombectomy was immediately performed because the symptoms were acute, and signs of swelling and pain intensity did not improve. An 8-F catheter was inserted into the patient's right distal superficial femoral vein under ultrasound guidance after administration of intravenous heparin. The CAT8 was inserted through the 8-F sheath and found the thrombus, then vacuum thrombectomy was performed. Swelling and pain disappeared a few hours after the procedure, and the patient was discharged 2 days later.
Conclusion: The Indigo CAT 8 mechanical aspiration thrombectomy system can be an effective treatment modality for patients with acute iliofemoral or central deep vein thrombosis.

Latar Belakang: Trombosis vena dalam akut adalah penyebab umum morbiditas dan mortalitas. Trombosis vena umumnya melibatkan ekstremitas bawah, termasuk vena iliaka, vena femoralis, dan vena cava. Terapi optimal trombosis vena dalam, baik ileofemoral maupun sentral dapat mencegah komplikasi.
Presentasi Kasus: Seorang laki-laki 51 tahun mengeluh kaki kanan bengkak disertai nyeri akut. Pada pemeriksaan ultrasonografi dupleks, terdapat trombosis vena di daerah iliofemoral turun dari vena iliaka komunis ke vena femoralis dalam. Trombektomi mekanik vena endovaskular segera dilakukan karena gejalanya akut, dan tanda pembengkakan serta intensitas nyeri tidak membaik. Kateter 8-F dimasukkan ke dalam vena femoralis superfisial distal kanan pasien di bawah panduan ultrasonografi setelah pemberian heparin intravena. Kateter CAT8 dimasukkan melalui selubung 8-F dan ditemukan trombus, kemudian dilakukan trombektomi vakum. Bengkak dan nyeri menghilang beberapa jam setelah prosedur, dan pasien dipulangkan 2 hari kemudian.
Simpulan: Sistem trombektomi aspirasi mekanik Indigo CAT 8 dapat menjadi modalitas pengobatan yang efektif untuk pasien dengan trombosis vena dalam sentral atau iliofemoral akut.
Luaran klinis pada pasien dengan penyakit hirschprung paska tindakan transanal Swenson-like dan transanal Soave satu tahap
Authors: Giri Nyoman Rudy Kurniawan , Darmajaya Made , Widiana I Gde Raka 
Published: November 2023

Introduction: Hirsprung's case surgery method is usually done through 3 stages. Since the three-step method greatly influences the incidence of postoperative enterocolitis and malnutrition, a single-stage surgery technique was developed. This technique is safe, cost-effective, and avoid stoma-related morbidity in infants. This study aimed to determine the difference in the clinical outcome between Swenson-like transanal and Soave 1 stage transanal procedures in patients with hirschsprung's disease.
Methods: This was a retrospective cohort study by taking secondary data from patient medical records from years 2017 to 2021. The total sample of 100 Hirschprung patients was divided into two groups; patients with transanal Swenson-like surgical techniques and Soave. Data were tabulated and statistically analyzed with descriptive and association analysis.
Results: There were differences in operating time based on the surgical technique used, with a median of 120.00 minutes in the 1st stage Swenson-like transanal technique group and 150.17 minutes in the transanal Soave group. The length of stay of patients with the Swenson-like surgical technique was shorter than the Soave technique (p <0.001). Postoperative complications of enterocolitis were less common with the Swenson-like technique than with the Soave technique.
Conclusion: There are differences in clinical outcomes in postoperative Hirschsprung patients with the Swenson-like and Soave 1 stage transanal technique..

Pendahuluan: Metode pembedahan kasus hirschsprung pada umumnya dilakukan melalui 3 tahap. Namun metode tiga tahap sangat berpengaruh terhadap kejadian enterokolitis dan malnutrisi paska pembedahan, sehingga dikembangkan pembedahan dengan teknik 1 tahap yang diketahui aman, cost-effective, dan menghindari morbiditas akibat stoma pada bayi. Penelitian ini bertujuan untuk mengetahui perbedaan luara klinis antara tindakan transanal Swenson-like dan transanal Soave 1 tahap pada pasien dengan penyakit Hirschsprung.
Metode: Penelitian ini merupakan penelitian retrospective cohort dengan mengambil data sekunder dari rekam medis pasien dari tahun 2017 sampai 2021. Total sampel sebanyak 100 pasien Hirschprung dibagi menajadi dua kelompok, yaitu teknik operasi transanal Swenson-like dan teknik operasi Soave. Data ditabulasi dan dianalisis statistik dengan menggunakan uji deskriptif dan asosiasi.
Hasil: Terdapat perbedaan lama waktu operasi berdasarkan teknik operasi yang digunakan, dengan median 120,00 menit pada kelompok teknik transanal Swenson-like 1 tahap dan 150,17 menit pada kelompok transanal Soave. Durasi lama rawat inap pasien teknik operasi Swenson-like lebih singkat dibandingkan teknik Soave (p < 0,001). Komplikasi enterokolitis paska bedah lebih jarang terjadi pada teknik operasi Swenson-like dibandingkan dengan Soave.
Simpulan: Terdapat perbedaan luara klinis pada pasien hirschsprung paska tindakan bedah dengan teknik transanal Swenson-like dan Soave 1 tahap.
Omicron tidak meningkatkan Neutrophil to Lymphocyte Ratio (NLR) di Rumah Sakit Darurat Covid-19 (RSDC) Wisma Atlet Kemayoran: studi pendahuluan
Authors: Amelia Winda , Lee Jemimah Kezia , Karina Silvia Yanita , Sidharta Karolin Dwi Setiowati 
Published: November 2023

Background: Neutrophil Lymphocyte Ratio (NLR), which is the sum of neutrophils divided by lymphocytes, has an important role in determining the inflammatory state in the patient. RNL is one of the markers of inflammation that is simple, rapid, and can be performed on routine blood tests.
Methods: This research is a retrospective descriptive study that examined NLR levels in patients confirmed with the Omicron variant of COVID-19 infection at the Wisma Atlet COVID-19 Hospital, Kemayoran, Jakarta. Data were analyzed using SPSS version 20.0 for Windows.
Results: From 331 samples, 187 samples were found to be female and 144 samples were male. A total of 300 samples had no increase in NLR (NLR <3.13), while the other 31 samples had an increase in NLR (NLR >3.13). Cytokine storm associated with immune dysregulation occurs less in women than in men. Almost all patients with confirmed Omicron variant COVID-19 at the Wisma Atlet Kemayoran Hospital did not experience an increase in NLR.
Conclusion: The cytokine storm associated with immune dysregulation occurs less frequently in women than in men. Almost all patients confirmed with the Omicron variant of COVID-19 at Wisma Atlet Hospital Kemayoran did not experience an increase in NLR.

Latar Belakang: Rasio Limfosit Neutrofil (RNL), yang merupakan jumlah neutrofil dibagi dengan limfosit, memiliki peran penting dalam menentukan keadaan inflamasi pada pasien. RNL merupakan salah satu penanda inflamasi yang sederhana, cepat, dan dapat dilakukan pada pemeriksaan darah rutin.
Metode: Penelitian ini merupakan studi deskriptif retrospektif yang meneliti kadar RNL pada pasien terkonfirmasi infeksi COVID-19 varian Omicron di Rumah Sakit COVID-19 Wisma Atlet, Kemayoran, Jakarta. Data dianalisis dengan SPSS versi 20.0 untuk Windows.
Hasil: Dari 331 sampel, ditemukan 187 sampel berjenis kelamin perempuan dan 144 sampel berjenis kelamin laki-laki. Sebanyak 300 sampel tidak mengalami peningkatan NLR (NLR <3,13), sedangkan 31 sampel lainnya mengalami peningkatan NLR (NLR >3,13). Badai sitokin yang terkait dengan disregulasi imun terjadi lebih sedikit pada wanita dibandingkan pada pria. Hampir seluruh pasien terkonfirmasi varian Omicron COVID-19 di RS Wisma Atlet Kemayoran tidak mengalami peningkatan NLR.
Simpulan: Badai sitokin terkait dengan disregulasi imun, terjadi lebih sedikit pada wanita dibandingkan dengan laki-laki.hampir seluruh pasien terkonfirmasi COVID-19 varian Omicron di RSDC Wisma Atlet Kemayoran tidak mengalami peningkatan RNL.
Clinical profile of patients with pseudoexfoliation glaucoma in Bali Mandara Eye Hospital from January to December 2022: a descriptive retrospective Study
Authors: Natan Priscilla Christina , Yinvill  , Rahayu Ni Kompyang 
Published: November 2023

Background: Pseudoexfoliative glaucoma (PEX glaucoma) is a type of secondary either open or closed-angle glaucoma that is characterized by the accumulation of flaky, whitish material on the surface of the eye. This material, known as pseudoexfoliative material (PEX), can clog the eye's drainage system, leading to increased intraocular pressure and eventual optic nerve damage if left untreated. This study aimed to describe the characteristic and management of PEXG in the Bali Mandara Eye Hospital Denpasar.
Methods: A descriptive retrospective study was conducted in March-April 2023 using electronic medical records of PEXG patients in the Bali Mandara Eye Hospital Denpasar from January–December 2022.
Results: There were 26 patients (37 eyes) diagnosed as PEXG; most of them were male (88.4%), aged 60-69 years old (34.4%), and followed by those in the range of age 70–79 years old (42.3%). Most of the cases were bilateral (59.5%) with a decrease of visual acuity of less than 3/60 (54%), an increase of intraocular pressure (IOP) with the majority in the range of 20-29 mmHg (35.1%), and 10-19 mmHg (29.8%), and followed by those who have a history of metabolic disease with Hypertension found on ten patients (38.4%) and Diabetes Mellitus on three patients (11.5%). The treatment combined several types of antiglaucoma medication and glaucoma surgery with patients who had undergone surgery in 19 eyes (51.3%). And the post-operative visual acuity was measured and showed the most favorable results, with normal eyes found in 14 eyes (73.6%).
Conclusion: PEX Glaucoma is commonly found in elderly patients. At the same time, most patients come with high IOP and late stage of the disease. The most frequent treatment is triple procedure surgery which produces a significant visual acuity improvement.
Karakteristik tajam penglihatan, tekanan bola mata dan penyakit mata masyarakat Desa Celuk, Gianyar Provinsi Bali di era pandemi COVID 19
Authors: Ni Kadek Puspa Mega Putri Sudibia  , Ni Made Ari Suryathi  , Ni Made Suryanadi  , I Wayan Eka Sutyawan  , Ni Made Laksmi Utari  , I Gusti Ayu Ratna Suryaningrum  
Published: November 2023

Background: It is an important effort to do a visual and intraocular pressure by conducting examination directly to the community due to support the Indonesian Ministry of Health to reduce the prevalence of blindness by 2030. This examination will produce epidemiological data.
Aim: To find out the characteristics of visual acuity, intraocular pressure and eye disease in the people of Celuk Village, Gianyar, Bali in the Era of Covid 19 pandemic.
Methods: Observational descriptive of the people of Celuk Village, Gianyar Regency, Bali
Results: Visual examination results in the right and left eyes were mostly normal. The results of tonometry showed that most people still have normal eye pressure. The data obtained from the examination results to the public can be used as a reference value in the normal population. Strategies that can be taken to prevent the transmission of COVID-19 during external examinations are choosing a large location, adjusting the seat distance, setting the time of patient arrival, officers must be vaccinated, antigen swabs are carried out, and use PPE.
Conclusion: In this study, the most common visual disturbance was age-related presbyopia.

Latar belakang: Pemeriksaan visus dan tekanan bola mata dengan turun langsung ke masyarakat sangat penting untuk dilakukan karena menunjang harapan Kemenkes RI menurunkan prevalensi kebutaaan tahun 2030. Pemeriksaan ini akan menghasilkan data epidemiologis.
Tujuan: Untuk mengetahui karakteristik tajam penglihatan, tekanan bola mata dan penyakit mata masyarakat Desa Celuk, Gianyar Provinsi Bali di era pandemi COVID 19
Metode: Deskriptif observasional pada masyarakat Desa Celuk, Kabupaten Gianyar, Provinsi Bali.
Hasil: Visus mata kanan dan kiri sebagian besar normal. Hasil tonometri mendapatkan sebagian besar masyarakat masih memiliki tekanan bola mata normal. Data yang diperoleh dari hasil pemeriksaan tersebut ke masyarakat dapat digunakan sebagai referensi nilai normal di populasi. Strategi yang dapat dilakukan untuk pencegahan transmisi COVID-19 selama skrining dan pemeriksaan luar adalah memilih lokasi yang luas, mengatur jarak kursi tunggu, mengatur waktu kedatangan pasien, seluruh petugas wajib divaksinasi, dilakukan swab antigen, dan menggunakan APD.
Simpulan: Pada penelitian ini gangguan penglihatan yang paling banyak adalah presbiopia terkait dengan usia.
Potency of Micro-Gels in Effective Management of Fungal Infection Diseases
Authors: Sisodia Harsh Kr. , Verma Vivek , Khalid Mohd. 
Published: November 2023

Microemulgel has vast application treating and preventing skin infection for better absorption and reducing toxicity. Microemulgel offer new alternation for the design that can be against fungal infection. Microemulgel formulation increase the efficacy, diffusion, permeation of drug and give optimum result. Microemulgel combination of both gel and mcroemulsion so it increases patient compliance. In this review we provide a broad overview on the uses of microemulgel in fight against fungal infection we have analyzed some research on microemulgel as a potential step for fungal treatment. We also give a brief summary of research that has been done and novel development show promise for the further growth of microemulgel in the pharmaceutical field.
, , , ,