bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased IL-4 is the risk factor of depression in patients with Takayasu arteritis
Authors: Zhang Yaxin , Yang Shiyu , Fan Anyuyang , Du Juan , Gao Na , Pan Lili , Li Taotao 
Published: February 2024

ObjectiveDepression is a common complication in Takayasu arteritis (TA). Disorders of the immune system play an important role in both diseases. This study aimed to clarify the feature of cytokines in TA patients with depression.MethodsIn this cross-sectional study, serum cytokines were tested in 40 TA patients and 11 healthy controls using the Bio-Plex Magpix System (Bio-Rad®). The state of depression was measured by the Zung Self-Rating Depression Scale (SDS) in TA patients. Logistic regression analysis was performed to find the risk factors of depression in patients with TA.ResultsTA patients with depression had higher ESR, hsCRP, NIH, and ITAS.A than patients without depression (16.00 [10.00, 58.50]mm/H vs. 7.50 [4.50, 17.75]mm/H, p = 0.013; 7.60 [2.32, 46.52]mg/L vs. 0.71 [0.32, 4.37]mg/L, p = 0.001; 2.00 [2.00, 3.00] vs. 1.00 [0.00, 2.00], p = 0.007; 7.00 [4.00, 9.50] vs. 1.50 [0.00, 5.75], p = 0.012, respectively). Additionally, the lower age of onset and levels of IL-4, IL-13, eotaxin, and IP-10 were observed in the depressed group compared with the non-depressed (23.50 [19.25, 32.50]pg./ml vs. 37.00 [23.25, 42.50]pg./ml, p = 0.017; 2.80 [2.17, 3.18]pg./ml vs. 3.51 [3.22, 4.66]pg./ml, p &lt; 0.001; 0.66 [0.60, 1.12]pg./ml vs. 1.04 [0.82, 1.25]pg./ml, p = 0.008; 46.48 [37.06, 61.75]pg./ml vs. 69.14 [59.30, 92.80]pg./ml, p = 0.001; 184.50 [138.23, 257.25]pg./ml vs. 322.32 [241.98, 412.60]pg./ml, p = 0.005, respectively). The lower level of IL-4 and age of onset were the independent risk factors for depression in TA patients (OR [95% CI] 0.124 [0.018, 0.827], p = 0.031; 0.870 [0.765, 0.990], p = 0.035, respectively).ConclusionOur data suggested that lower cytokine levels, especially IL-4, might be involved in the development of TA patients with depression. Clinicians can probably use serum IL-4 level testing as a potential indicator of depression in TA.
Dosimetric benefit of online treatment plan adaptation in stereotactic ultrahypofractionated MR-guided radiotherapy for localized prostate cancer
Authors: Fink Christoph A. , Buchele Carolin , Baumann Lukas , Liermann Jakob , Hoegen Philipp , Ristau Jonas , Regnery Sebastian , Sandrini Elisabetta , König Laila , Rippke Carolin , Bonekamp David , Schlemmer Heinz-Peter , Debus Juergen , Koerber Stefan A. , Klüter Sebastian , Hörner-Rieber Juliane 
Published: February 2024

BackgroundApart from superior soft tissue contrast, MR-guided stereotactic body radiation therapy (SBRT) offers the chance for daily online plan adaptation. This study reports on the comparison of dose parameters before and after online plan adaptation in MR-guided SBRT of localized prostate cancer.Materials and methods32 consecutive patients treated with ultrahypofractionated SBRT for localized prostate cancer within the prospective SMILE trial underwent a planning process for MR-guided radiotherapy with 37.5 Gy applied in 5 fractions. A base plan, derived from MRI simulation at an MRIdian Linac, was registered to daily MRI scans (predicted plan). Following target and OAR recontouring, the plan was reoptimized based on the daily anatomy (adapted plan). CTV and PTV coverage and doses at OAR were compared between predicted and adapted plans using linear mixed regression models.ResultsIn 152 out of 160 fractions (95%), an adapted radiation plan was delivered. Mean CTV and PTV coverage increased by 1.4% and 4.5% after adaptation. 18% vs. 95% of the plans had a PTV coverage ≥95% before and after online adaptation, respectively. 78% vs. 100% of the plans had a CTV coverage ≥98% before and after online adaptation, respectively. The D0.2cc for both bladder and rectum were &lt;38.5 Gy in 93% vs. 100% before and after online adaptation. The constraint at the urethra with a dose of &lt;37.5 Gy was achieved in 59% vs. 93% before and after online adaptation.ConclusionOnline adaptive plan adaptation improves target volume coverage and reduces doses to OAR in MR-guided SBRT of localized prostate cancer. Online plan adaptation could potentially further reduce acute and long-term side effects and improve local failure rates in MR-guided SBRT of localized prostate cancer.
Individually optimized estimation of energy expenditure in rescue workers using a tri-axial accelerometer and heart rate monitor
Authors: Ogata Hitomi , Negishi Yutaro , Koizumi Nao , Nagayama Hisashi , Kaneko Miki , Kiyono Ken , Omi Naomi 
Published: February 2024

Objectives: This study aimed to provide an improved energy expenditure estimation for heavy-load physical labor using accelerometer data and heart rate (HR) measured by wearables and to support food preparation and supply management for disaster relief and rescue operations as an expedition team.Methods: To achieve an individually optimized estimation for energy expenditure, a model equation parameter was determined based on the measurements of physical activity and HR during simulated rescue operations. The metabolic equivalent of task (MET), which was measured by using a tri-axial accelerometer and individual HR, was used, where two (minimum and maximum) or three (minimum, intermediate, and maximum) representative reference points were selected for each individual model fitting. In demonstrating the applicability of our approach in a realistic situation, accelerometer-based METs and HR of 30 males were measured using the tri-axial accelerometer and wearable HR during simulated rescue operations over 2 days.Results: Data sets of 27 rescue operations (age:34.2 ± 7.5 years; body mass index (BMI):22.9 ± 1.5 kg/m2) were used for the energy expenditure estimation after excluding three rescue workers due to their activity type and insufficient HR measurement. Using the combined approach with a tri-axial accelerometer and HR, the total energy expenditure increased by 143% for two points and 133% for three points, compared with the estimated total energy expenditure using only the accelerometer-based method.Conclusion: The use of wearables provided a reasonable estimation of energy expenditure for physical workers with heavy equipment. The application of our approach to disaster relief and rescue operations can provide important insights into nutrition and healthcare management.
Cost-effectiveness of first-line versus second-line use of brigatinib followed by lorlatinib in patients with ALK-positive non-small cell lung cancer
Authors: Liu Wenjie , Huo Gengwei , Chen Peng 
Published: February 2024

BackgroundThe ALTA-1 L trial and EXP-3B arm of NCT01970865 trial found that both brigatinib and lorlatinib showed durable and robust responses in treating ALK-positive non-small cell lung cancer (NSCLC) patients. However, brigatinib and lorlatinib treatments are costly and need indefinite administration until the disease progression. Thus, it remains uncertain whether using brigatinib followed by lorlatinib before chemotherapy is cost-effective compared to reserving these two drugs until progression after chemotherapy.MethodsWe used a Markov model to assess clinical outcomes and healthcare costs of treating ALK-positive NSCLC individuals with brigatinib followed by lorlatinib before chemotherapy versus a strategy of reserving these drugs until progression after chemotherapy. Transition probabilities were estimated using parametric survival modeling based on multiple clinical trials. The drug acquisition costs, adverse events costs, administration costs were extracted from published studies before and publicly available data. We calculated lifetime direct healthcare costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios from the perspective of a United States payer.ResultsOur base-case analysis indicated that the incremental cost-effectiveness ratios of using first-line brigatinib followed by lorlatinib compared with second-line brigatinib followed by lorlatinib is $-400,722.09/QALY which meant that second-line brigatinib followed by lorlatinib had less costs and better outcomes. Univariate sensitivity analysis indicated the results were most sensitive to the cost of brigatinib. Probability sensitivity analysis revealed that using brigatinib followed by lorlatinib before chemotherapy had a 0% probability of cost-effectiveness versus delaying these two drugs until progression after chemotherapy at a willingness-to-pay threshold of $150,000 per QALY. Sensitivity analyses conducted revealed the robustness of this result, as incremental cost-effectiveness ratios never exceeded the willingness-to-pay threshold.ConclusionUsing brigatinib as first-line treatment followed by lorlatinib for ALK-positive NSCLC may not be cost-effective given current pricing from the perspective of a United States payer. Delaying brigatinib followed by lorlatinib until subsequent lines of treatment may be a reasonable strategy that could limit healthcare costs without affecting clinical outcomes. More mature data are needed to better estimate cost-effectiveness in this setting.
Detection of spondylosis deformans in thoracolumbar and lumbar lateral X-ray images of dogs using a deep learning network
Authors: Park Junseol , Cho Hyunwoo , Ji Yewon , Lee Kichang , Yoon Hakyoung 
Published: February 2024

IntroductionSpondylosis deformans is a non-inflammatory osteophytic reaction that develops to re-establish the stability of weakened joints between intervertebral discs. However, assessing these changes using radiography is subjective and difficult. In human medicine, attempts have been made to use artificial intelligence to accurately diagnose difficult and ambiguous diseases in medical imaging. Deep learning, a form of artificial intelligence, is most commonly used in medical imaging data analysis. It is a technique that utilizes neural networks to self-learn and extract features from data to diagnose diseases. However, no deep learning model has been developed to detect vertebral diseases in canine thoracolumbar and lumbar lateral X-ray images. Therefore, this study aimed to establish a segmentation model that automatically recognizes the vertebral body and spondylosis deformans in the thoracolumbar and lumbar lateral radiographs of dogs.MethodsA total of 265 thoracolumbar and lumbar lateral radiographic images from 162 dogs were used to develop and evaluate the deep learning model based on the attention U-Net algorithm to segment the vertebral body and detect spondylosis deformans.ResultsWhen comparing the ability of the deep learning model and veterinary clinicians to recognize spondylosis deformans in the test dataset, the kappa value was 0.839, indicating an almost perfect agreement.ConclusionsThe deep learning model developed in this study is expected to automatically detect spondylosis deformans on thoracolumbar and lumbar lateral radiographs of dogs, helping to quickly and accurately identify unstable intervertebral disc space sites. Furthermore, the segmentation model developed in this study is expected to be useful for developing models that automatically recognize various vertebral and disc diseases.
Proportion of At-Risk Alcohol Consumers According to the New French Guidelines: Cross-Sectional Weighted Analyses From the CONSTANCES Cohort
Authors: El Haddad Rita , Renuy Adeline , Wiernik Emmanuel , Melchior Maria , Zins Marie , Airagnes Guillaume 
Published: February 2024

Objective: To estimate the proportion of the participants of the French national population-based CONSTANCES cohort exceeding the new low-risk drinking guidelines according to sociodemographic and clinical factors.Methods: From 34,470 participants with follow-up data in 2019, among volunteers aged 18–69 years and invited to enroll in the CONSTANCES cohort in 2016 and 2017, weighted prevalence and odds ratios with 95% confidence intervals (CI) exceeding the guidelines using logistic regressions were presented stratified for age, gender, education, occupational grade, employment, income, marital status, pregnancy, work stress, depression, alcohol dependence, binge drinking, cannabis use, smoking status, e-cigarette use, cardiovascular diseases, and cancer.Results: The guidelines were exceeded more by men at 60.2% (95%CI: 59.3%–61.0%) than by women at 36.6% (95%CI: 35.9%–37.4%). Exceeding the guidelines increased with age, socioeconomic status, smoking, vaping, using cannabis, binge drinking, and alcohol dependence. Being depressed was associated with exceeding the guidelines in women. Even though pregnant women were less likely to exceed the guidelines, 7.6% (95%CI: 5.4%–10.6%) were at-risk drinkers.Conclusion: These findings highlight the need to implement effective prevention measures for at-risk alcohol use among the French population.
Genomic Surveillance Uncovers a 10-Year Persistence of an OXA-24/40 Acinetobacter baumannii Clone in a Tertiary Hospital in Northern Spain
Authors: Aranzamendi Maitane , Xanthopoulou Kyriaki , Sánchez-Urtaza Sandra , Burgwinkel Tessa , Arazo del Pino Rocío , Lucaßen Kai , Pérez-Vázquez M. , Oteo-Iglesias Jesús , Sota Mercedes , Marimón Jose María , Seifert Harald , Higgins Paul G. , Gallego Lucía 
Published: February 2024

Infections caused by carbapenem-resistant Acinetobacter baumannii are a global threat causing a high number of fatal infections. This microorganism can also easily acquire antibiotic resistance determinants, making the treatment of infections a big challenge, and has the ability to persist in the hospital environment under a wide range of conditions. The objective of this work was to study the molecular epidemiology and genetic characteristics of two blaOXA24/40 Acinetobacter baumannii outbreaks (2009 and 2020-21) at a tertiary hospital in Northern Spain. Thirty-six isolates were investigated and genotypically screened by Whole Genome Sequencing to analyse the resistome and virulome. Isolates were resistant to carbapenems, aminoglycosides and fluoroquinolones. Multi-Locus Sequence Typing analysis identified that Outbreak 1 was mainly produced by isolates belonging to ST3Pas/ST106Oxf (IC3) containing blaOXA24/40, blaOXA71 and blaADC119. Outbreak 2 isolates were exclusively ST2Pas/ST801Oxf (IC2) blaOXA24/40, blaOXA66 and blaADC30, the same genotype seen in two isolates from 2009. Virulome analysis showed that IC2 isolates contained genes for capsular polysaccharide KL32 and lipooligosacharide OCL5. A 8.9 Kb plasmid encoding the blaOXA24/40 gene was common in all isolates. The persistance over time of a virulent IC2 clone highlights the need of active surveillance to control its spread.
Nota editorial - A la memoria de Jairo Urrea Henao
Authors: Fisgativa Carlos Mario 
Published: February 2024

Este número de la revista Disertaciones se presenta como un homenaje en memoria del profesor Jairo Urrea Henao. Nuestra portada lo presenta sentado en las inmediaciones del espacio de arte y memoria “Fragmentos” del Museo Nacional en Bogotá, un contra-monumento a la memoria de las victimas del conflicto en Colombia. Agradecemos a María Teresa Cruz Restrepo por su gentileza al aportarnos la fotografía que ella misma tomara de su compañero de vida.
Incluso en diciembre del año 2020 contamos con la compañía de Jairo. Gracias a las mediaciones tecnológicas que el contexto de pandemia había impuesto, su voz circulaba entre estudiantes y docentes del Programa de filosofía y de la Universidad del Quindío. A los cuales dedicó comprometida y tenazmente largos años de su enseñanza y de su comprensión del quehacer filosófico.
Uji antibakteri gel hand sanitizer ekstrak etanol bunga krisan (Chrysanthemum segetum) terhadap bakteri Staphylococcus aureus
Authors: Rumanti Ruth Mayana , Nasution Rizka Hasmi , Naldi Jefri 
Published: February 2024

Gel hand sanitizer memiliki kemampuan aktivitas bakteriosida yang baik terhadap bakteri dikulit. Adanya kandungan senyawa flavonoida dalam bunga krisan (Chrysanthemum segetum) berperan sebagai antibakteri aktif dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Studi ini bertujuan untuk menguji aktivitas antibakteri sediaan gel antiseptik tangan (hand sanitizer) ekstrak etanol bunga krisan terhadap bakteri Staphylococcus aureus. Prosedur meliputi pengumpulan, pembuatan simplisia, karakterisasi simplisia, pembuatan ekstrak dengan metode maserasi, sediaan gel dibuat menjadi konsentrasi 10%, 15% dan 20% dilanjutkan pengujian antibakteri metode difusi agar. Hasil uji zona hambat bakteri pada konsentrasi 10% dengan nilai rata-rata 3,76 mm, konsentrasi 15% sebesar 4,71 mm dan konsentrasi 20% sebesar 5,31 mm dengan kategori sedang.
Arahan Pengendalian Terhadap Banjir di Perumahan BTN Mutiara Indah Permai di Kecamatan Somba Opu Kabupaten Gowa
Authors: Yuniarto Eka , Latief Rudi , Ridwan Ridwan 
Published: February 2024

Banjir merupakan salah satu bencana alam yang banyak terjadi belakangan ini, terutama disaat musim penghujan. Selain kerugian material, bencana banjir dapat menimbulkan korban jiwa. Faktor utama penyebab terjadinya bencana adalah manusia yang dapat melakukan pengalihan fungsi lahan dari daerah yang seharusnya dapat meresap air menjadi lahan perumahan dan permukiman, perkebunan bahkan lahan perindustrian. Faktor lain yang dapat menimbulkan banjir adalah faktor alam, seperti kelerengan disuatu daerah dan juga kemampuan tanah dalam menyerap air hujan. Kondisi eksisiting pemanfaatan lahan di Kecamatan Somba Opu terdiri dari berbagai macam aktivitas seperti pemukiman penduduk, perdagangan dan jasa. Tujuan dari penelitian ini mengidentifikasi penyebab terjadinya banjir di Perumahan BTN Mutiara Indah Permai Kabupaten Gowa serta menentukan arahan pengendalian banjir yang tepat dan dapat dilaksanakan. Metode penelitian dilakukan dengan observasi langsung di lokasi, melakukan wawancara terhadap masyarakat yang terdampak. Analisa data menggunakan analisis hidrologi dengan berdasar pada identifikasi penyebab banjir untuk menghitung debit limpasan, debit rencana dan daya tampung sistem drainase. Hasil dari penelitian ini diperolaeh bahwa sistem jaringan drainase di BTN Mutiara Indah Permai tidak dapat menampung debit air ketika musim penghujan akibat adanya limpasan air berupa banjir kiriman, upaya mitigasi banjir dilakukan dengan memperbesar kapasitas debit saluran drainase serta memperkecil debit limpasan.
Flooding is one of the most common natural disasters in recent time especially during in rainy season. Besides material losses, flood disasters can cause loss of life. The main factor causing disaster is human who can divert land function from area that be able to absorb water into housing and settlement, plantation and even industrial land. Other factors that can cause flooding are natural factor, such as the slope in an area and also the ability of the soil to absorb rainwater. The existing condition of land use in Somba Opu sub-district consists of various activities such as residential, trade and service. The purpose of this study was to identify the causes of flooding in the BTN Mutiara Indah Permai Gowa and determine appropriate flood control direction that can be implemented. The research method was carried out by direct observation at the location through interview with affected community. Data analysis using hydrological analysis based on the identification of flood causes to calculate runoof discharge, plan discharge and drainage system capacity. The result of this study found that the drainage network system in BTN Mutiara could not accommodate water discharge during the rainy season due to water runoff in the form of flood shipments, flood mitigation efforts are carried out by increasing the discharge capacity of drainage channels and minimizing runoff discharge
Pengaruh Media Pakapindo (Papan Kantong Pintar Doraemon) terhadap Hasil Belajar Tematik Kelas III SD YPK Inamo Kabupaten Sorong
Authors: Irianti Rindiani Putri , Fitriani Anis Alfian , Kusumaningrum Syams 
Published: February 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Media PAKAPINDO Terhadap Hasil Belajar Tematik kelas III SD YPK Inamo Kabupaten Sorong. Penelitian ini merupakan Pre-Exprerimental Design. Variabel bebas dalam penelitian ini adalah pengaruh penggunaan media papan kantong pintar doraemon sedangkan variabel terikatnya adalah hasil belajar peserta didik. Sampel dalam penelitian ini berjumlah 14 peserta didik. Teknik pengumpulan data yang digunakan adalah tes performance, lembar observasi dan dokumentasi kegiatan proses pembelajaran. Teknik analisis data terdiri dari tahap uji validitas, uji reliabilitas, uji normalitas, uji hipotesis, dan uji N-Gain. Hasil uji reliabilitas diperoleh Cronbach’s Alpha sebesar 0,803 yang berarti reliabiltas baik. Uji normalitas hasil belajar pretest peserta didik kelas III memiliki signifikan 0,234 0,05 edangkan posttest memiliki signifikansi 0,059 0,05 Uji hipotesis diperoleh Thitung sebesar 25.480 dengan dk = n – 1 (14-1 = 13) diperoleh ttabel sebesar 1.771 hasil sig (2-tailed) sebesar 0,000. Berdasarkan hasil nilai 0,000 lebih kecil dari 0,05 dimana 0,000 0,05 maka nilai sig lebih kecil dari 0,05 hasil dari pengujian ini menunjukkan bahwa H1 diterima dan H0 ditolak artinya ada pengaruh penggunaan media papan kantong pintar doraemon terhadap hasil belajar tematik kelas III SD YPK Inamo Kabupaten Sorong.
موقف بريطانيا من إنشاء مكتب جامعة الدول العربية في إمارات الساحل المتصالح سنة 1965م (قراءة في الوثائق البريطانية – لندن)
Authors: الشحي أحمد , شـترة خير الديـــن 
Published: February 2024

تتناول هذهِ الدّراسة فحوى وغايات الزيارة الودية التي أدّاها وفد جامعة الدول العربية برئاسة أمينها العام آنذاك السيد عبد الخالق حسونة إلى منطقة إمارات الساحل المتصالح عام 1964م، والتي تعتبر منعرجاً حاسماً في تاريخ العلاقات الدولية بين إمارات الساحل المتصالح، والعالم الخارجي؛ إذ ترتب عليها انعكاسات غيَّرت من مجرى الأحداث السياسية بالمنطقة في اتجاه مسعى فك الارتباط مع الطرف البريطاني والتخلص من تبعات الاتفاقيات والمعاهدات التي أبرمت بين الطرفين.
لقد سلطت هذه الدراسة الضوء على ما تضمنته هذه التقارير والمراسلات الرسمية بما يتيح لها استجلاء الموقف البريطاني حينها من هذا الاختراق لمجال نفوذها الذي احتكرته لنفسها على مدى ما يقرب من قرن ونصف القرن، خصوصاً أن أكثر ما كانت تخشاه الدبلوماسية البريطانية هو انتشار المد القومي العربي (الناصري) في الخليج العربي، فما القيمة السياسية والاستراتيجية لهذه الزيارة؟ وما مدى التأثير المتوقع لجامعة الدول العربية على إمارات الساحل المتصالح بعد اقتراح إنشاء مكتب تنمية عربي؟ وما الإجراءات التي اتخذتها الحكومة البريطانية عن طريق وكلائها بالمنطقة لإفشال هذا المسعى؟ وافــــتـرضت الدّراسة أنَّ الزيارة الودية لوفد الجامعة العربية إلى منطقة الخليج العربي، وإن لم تُوفق في تحقيق كل أهدافها إلا أنها أسهمت بشكل مؤثر في إعادة إحياء جذوة الروح القومية والانتماء إلى الأمة العربية.
مسؤولية الدولة عن تعويض المجني عليه "دراسة مقارنة"
Authors: غانم امنة , العاني محمد 
Published: February 2024

إن أهم الالتزامات والواجبات التي تقع على عاتق الدولة تتمثل بكفالة حماية أفراد المجتمع من أي عدوان أو سلوك إجرامي يقع عليهم، وتمارس الدولة هذا الحق بمختلف أجهزتها وسلطاتها بما يحول دون وقوع الاعتداء على أفراد المجتمع، وإذا ما أخفقت الدولة في ذلك الالتزام تحققت مسؤوليتها عن هذا الاعتداء، وكثيراً يحصل أن يعجز المجني عليه من الحصول على التعويض العادل عن الضرر الذي تعرض له، مما يفضي ذلك إلى ضياع حقه، وبناء على ذلك ظهرت دعوات عديدة تدعو إلى ضرورة تحمل الدولة لواجبها في تعويض المجني عليه عن الضرر، كما حرصت العديد من المواثيق الدولية والمؤتمرات العلمية على اعتبار أن التعويض من قبل الدولة يعد حقاً من حقوق المجني عليه في الدعوى الجزائية، فمسؤولية الدولة بكفالة حقوق الأفراد وضمانها ليست مجرد ادعاء وإنما هو التزام على الدولة بتهيئة الوسائل اللازمة لحماية هذه الحقوق وتطبيق العقوبة المناسبة لها عند المساس بها.