bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness and safety of temporary transvenous cardiac pacing leads placement into coronary sinus vein in patients with sick sinus syndrome
Authors: Chen Mingxian , Wu Zhihong , Hu Lin , Li Xuping , Yang Hui , Liu Zhenjiang , Xiao Yichao , Liu Qiming , Zhou Shenghua 
Published: November 2023

AbstractBackgroundThe temporary pacing lead routinely is placed into right ventricular (RV), which pose a risk of dislocation and cardiac perforation.ObjectiveWe aim to evaluate the effectiveness and safety of temporary transvenous cardiac pacing (TTCP) leads placement into the coronary sinus vein (CSV) in patients with sick sinus syndrome (SSS).MethodsWe investigated patients with SSS who underwent TTCP lead placement into the CSV under the guidance of X‐ray between January 2013 and May 2023. Patients were randomly divided into two groups: RV group (n = 33) and CSV group (n = 22). The ordinary passive bipolar electrodes were applied in both groups. In RV groups, electrodes were placed into RV. In CSV group, electrodes were placed into CSV. We evaluated the operation duration, fluoroscopic exposure, first‐attempt success rate of leads placement, pacing threshold, success rate of leads placement, rate of leads displacement, and complications.ResultsCompared with that in RV group, the procedure time, fluoroscopic exposure was significantly prolonged, while the first‐attempt success rate of lead placement was obviously increased in CSV group (both p < .05). Compared with that in RV group, the rate of leads displacement is lower in CSV group (both p < .05). There were three patients occurred cardiac perforation in RV group, but no cardiac perforation was reported in CSV group (p > .05).ConclusionTTCP leads placement into the CSV is an effective and safe strategy in patients with SSS. It indicates a high rate of pacing effectiveness with low device replacement and complication rates.
Grassland Geopoetics: Son Jarocho and the Black Sense of Place of Plantations and Pastures
Authors: Astorga de Ita Diego 
Published: November 2023

AbstractThis essay considers how the grasslands of the Mexican region of El Sotavento entangle with the history of racial capitalism and with traditional Sotaventine music. Throughout this text, I argue that son Jarocho music and its poetics counterpoint racist colonial discourses making space for ways of being beyond racial capitalism. I review the history of Sotaventine grasslands, counterpointing their historical becomings with ethnographic materials and current poetic expressions. I especially focus on two sones: La Caña, written in the 1990s by Patricio Hidalgo Belli regarding sugarcane, and the 18th century Toro Zacamandú that speaks of cowboying. Using scholarly writings on the plantation and plantation histories from McKittrick and Glissant, King's work on fungibility, scholarship on Maroon landscapes and marronage, and an array of writers who explore poetics and geopoetics, we shall see how racial capitalism and the historical becomings of plantations and pastures are reflected and overturned in Sotaventine sounds.
Comparing the outcomes of laparoscopic proximal and laparoscopic total gastrectomy: A retrospective analysis of a single center in Japan
Authors: Aizawa Masaki , Yabusaki Hiroshi , Aoki Ryota , Bamba Takeo , Nakagawa Satoru 
Published: November 2023

AbstractIntroductionDespite the increasing performance of laparoscopic proximal gastrectomy (LPG) for proximal gastric cancer and esophagogastric junction cancer, the benefit of LPG over laparoscopic total gastrectomy (LTG) remains to be established. Therefore, this study was conducted to compare postoperative outcomes between LPG and LTG.MethodsData from 141 patients who underwent LPG or LTG for gastric neoplasm with curative intent between 2016 and 2022 were retrospectively reviewed. Clinicopathological findings, body weight changes, and serological nutritional markers during the postoperative course were evaluated.ResultsLPG and LTG were performed in 78 patients and 63 patients, respectively. Patients' characteristics did not differ; however, tumor stages in patients who underwent LTG were more advanced than those who underwent LPG. The mean (± standard deviation) weight loss rate after 1 year was −13.5 (±6.9)% and −18.7 (±6.6)% for LPG and LTG, respectively (p < .01). LTG (OR: 3.326, p < .01), pT disease (OR: 3.000, p = .01), pN disease (OR: 2.708, p = .02), and postoperative chemotherapy (OR: 2.488, p = .05) were correlated with severe weight loss (16% or more) 1 year after surgery, then multivariate analysis identified LTG as an independent factor (p = .01). The mean (± standard deviation) serum total protein level of LPG was significantly higher than that of LTG at 3 months (6.8 ± 0.5 vs. 6.6 ± 0.4 g/dL, p = .02) and 1 year (6.9 ± 0.4 vs. 6.7 ± 0.5 g/dL, p = .01) postoperatively. No difference was observed in postoperative serum hemoglobin and albumin levels.ConclusionLPG more improved postoperative weight loss than LTG.
When pink is a question: Comparative gross and microscopic skin structure analyses reveal the histological basis of skin colour in Galápagos pink land iguanas (Conolophus marthae)
Authors: Lewbart Gregory A. , Colosimo Giuliano , Gaudette Christopher , Negrão Watanabe Tatiane T. , Parker Joshua , Sevilla Christian , Gerber Glenn P. , Gentile Gabriele 
Published: November 2023

AbstractOne of the rarest and most unusual iguanas on the planet is the Galápagos pink land iguana (Conolophus marthae). There have been a number of hypotheses on the source of their pink coloration, including that the colour is from blood and a relative lack of dermal pigmentation. We obtained full thickness skin biopsies of three species and compared tissue from darkly pigmented areas and lightly pigmented surfaces. “Pink” areas of pink iguanas are devoid of pigment cells (e.g. melanophores) and the dermal tissue is rich with aggregates of confluent capillaries. This was in sharp contrast to the minimally vascular (only capillaries were observed) dermal areas of the marine and yellow iguanas. The dermal stratum laxum of every biopsy site contained melanophores except for the pink skin of pink iguanas. Interestingly, marine iguanas have a much thicker epidermal stratum germinativum/granulosum, between 2 and 10 cells thick depending on location, compared to the thinner epidermal stratum germinativum/granulosum of land iguanas (one to three cells thick with most areas possessing just one or two cell layers). These microscopic differences might reflect differences in habitat and ecology of the three species.
Are female CEOs greener? Female CEOs and green innovation: The role of their political embeddedness
Authors: Tang Fei , Li Dayuan 
Published: November 2023

AbstractAre female CEOs greener? Few studies have explicitly scrutinised the roles of female CEOs and their political embeddedness in green innovation. In the present work, the influence of female CEOs on green innovation is first examined. Then, the effect of politically embedded female CEOs on green innovation is explored by differentiating female CEOs as those who are and who are not politically embedded, respectively. Furthermore, the moderating effects of external environmental factors on this relationship, namely market competition and market development, are investigated. Using data on China's publicly operated firms from 2008 to 2017, the findings suggest the following: (1) female CEOs negatively affect green innovation; (2) politically embedded female CEOs positively affect green innovation; (3) the positive influence of politically embedded female CEOs on green innovation is strengthened when firms are situated in less competitive industries and more developed markets. This article extends the research and current knowledge base about female CEOs, political embeddedness, and green innovation.
Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids
Authors: Toyohara Yusuke , Taguchi Ayumi , Ishii Yoshiyuki , Yoshimoto Daisuke , Yamazaki Miki , Matsunaga Hiroko , Nakatani Kazuma , Hoshi Daisuke , Tsuchimochi Saki , Kusakabe Misako , Baba Satoshi , Kawata Akira , Ikemura Masako , Tanikawa Michihiro , Sone Kenbun , Uchino‐Mori Mayuyo , Ushiku Tetsuo , Takeyama Haruko , Oda Katsutoshi , Kawana Kei , Hippo Yoshitaka , Osuga Yutaka 
Published: November 2023

AbstractHuman papillomavirus 18 (HPV18) is a highly malignant HPV genotype among high‐risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its high prevalence in adenocarcinomas. The cellular targets and molecular mechanisms underlying its infection remain unclear. In this study, we aimed to identify the cells targeted by HPV18 and elucidate the molecular mechanisms underlying HPV18 replication. Initially, we established a lentiviral vector (HPV18LCR‐GFP vector) containing the HPV18 long control region promoter located upstream of EGFP. Subsequently, HPV18LCR‐GFP vectors were transduced into patient‐derived squamocolumnar junction organoids, and the presence of GFP‐positive cells was evaluated. Single‐cell RNA sequencing of GFP‐positive and GFP‐negative cells was conducted. Differentially expressed gene analysis revealed that 169 and 484 genes were significantly upregulated in GFP‐positive and GFP‐negative cells, respectively. Pathway analysis showed that pathways associated with cell cycle and viral carcinogenesis were upregulated in GFP‐positive cells, whereas keratinization and mitophagy/autophagy‐related pathways were upregulated in GFP‐negative cells. siRNA‐mediated luciferase reporter assay and HPV18 genome replication assay validated that, among the upregulated genes, ADNP, FHL2, and NPM3 were significantly associated with the activation of the HPV18 early promoter and maintenance of the HPV18 genome. Among them, NPM3 showed substantially higher expression in HPV‐related cervical adenocarcinomas than in squamous cell carcinomas, and NPM3 knockdown of HPV18‐infected cells downregulated stem cell‐related genes. Our new experimental model allows us to identify novel genes involved in HPV18 early promoter activities. These molecules might serve as therapeutic targets in HPV18‐infected cervical lesions.
Children's overestimation of performance across age, task, and historical time: Ameta‐analysis
Authors: Xia Mengtian , Poorthuis Astrid M. G. , Thomaes Sander 
Published: November 2023

AbstractChildren tend to overestimate their performance on a variety of tasks and activities. The present meta‐analysis examines the specificity of this phenomenon across age, tasks, and more than five decades of historical time (1968–2021). Self‐overestimation was operationalized as the ratio between children's prospective self‐estimates of task performance and their actual (i.e., objectively measured) task performance. A total of 246 effect sizes from 43 published articles were analyzed (4277 participants; 49.6% girls; sample mean ages range from 4 to 12; 86.0% of studies conducted in North America or Europe). Children's self‐overestimation was robust across tasks, with their estimates of performance being 1.3 times their actual performance. In addition, children's self‐overestimation decreased with sample age and increased with the year of data collection.
Computer‐assisted and robotic implant surgery: Assessing the outcome measures of accuracy and educational implications
Authors: Pimkhaokham Atiphan , Chow James , Pozzi Alessandro , Arunjaroensuk Sirida , Subbalehka Keskanya , Mattheos Nikos 
Published: November 2023

AbstractObjectiveThis scoping review aimed to (1) critically evaluate the outcomes measures used to assess the accuracy of implant placement with Computer Assisted Implant Surgery (CAIS) and (2) review the evidence supporting the efficient implementation of CAIS in training and education of clinicians.MethodsA scoping literature review was conducted aiming to identify (a) clinical trials assessing accuracy of implant placement with CAIS, and (b) clinical trials or simulation/cadaver studies where CAIS was utilised and assessed for the training/education of clinicians. Studies since 1995 were assessed for suitability and data related to the outcomes measures of accuracy and educational efficacy were extracted and synthesised.ResultsAccuracy of CAIS has been mainly assessed through surrogate measures. Individual clinical trials have not shown any difference between static and dynamic CAIS, but recent meta‐analyses suggest an advantage of dynamic CAIS in reducing angular deviation. The combination of static and dynamic CAIS might offer higher accuracy than each of the two used alone. Dynamic CAIS is suitable for novice surgeons and might even have added value as an education tool for implant surgery, although mastering the technique requires longer training than static.ConclusionMeta‐analyses of large samples, new and diverse outcomes measures, as well as benchmarking of levels of accuracy with specific clinical outcomes will help to better understand the potential and limitations of CAIS. Dynamic CAIS is suitable for novice operators, but educational interventions distributed over longer periods of time will be required for mastery of the process.
Paraventricular thalamus‐insular cortex circuit mediates colorectal visceral pain induced by neonatal colonic inflammation in mice
Authors: Zhang Fu‐Chao , Wei Ying‐Xue , Weng Rui‐Xia , Xu Qi‐Ya , Li Rui , Yu Yang , Xu Guang‐Yin 
Published: November 2023

AbstractAimsIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, but its pathogenesis remains incompletely understood, particularly the involvements of central nervous system sensitization in colorectal visceral pain. Our study was to investigate whether the paraventricular thalamus (PVT) projected to the insular cortex (IC) to regulate colorectal visceral pain in neonatal colonic inflammation (NCI) mice and underlying mechanisms.MethodsWe applied optogenetic, chemogenetic, or pharmacological approaches to manipulate the glutamatergicPVT‐IC pathway. Fiber photometry was used to assess neuronal activity. Electromyography activities in response to colorectal distension (CRD) were measured to evaluate the colorectal visceral pain.ResultsNCI enhanced c‐Fos expression and calcium activity upon CRD in the ICGlu, and optogenetic manipulation of them altered colorectal visceral pain responses accordingly. Viral tracing indicated that the PVTGlu projected to the ICGlu. Optogenetic manipulation of PVTGlu changed colorectal visceral pain responses. Furthermore, selective optogenetic modulation of PVT projections in the IC influenced colorectal visceral pain, which was reversed by chemogenetic manipulation of downstream ICGlu.ConclusionsThis study identified a novel PVT‐IC neural circuit playing a critical role in colorectal visceral pain in a mouse model of IBS.
The phosphokinase activity of IRE1ɑ prevents the oxidative stress injury through miR‐25/Nox4 pathway after ICH
Authors: Liao Yuhui , Huang Juan , Wang Zhenhua , Yang Zhengyu , Shu Yue , Gan Shengwei , Wang Zhixu , Lu Weitian 
Published: November 2023

AbstractBackgroundEndoplasmic reticulum (ER) stress and oxidative stress are the major pathologies encountered after intracerebral hemorrhage (ICH). Inositol‐requiring enzyme‐1 alpha (IRE1α) is the most evolutionarily conserved ER stress sensor, which plays a role in monitoring and responding to the accumulation of unfolded/misfolded proteins in the ER lumen. Recent studies have shown that ER stress is profoundly related to oxidative stress in physiological or pathological conditions. The purpose of this study was to investigate the role of IRE1α in oxidative stress and the potential mechanism.MethodsA mouse model of ICH was established by autologous blood injection. The IRE1α phosphokinase inhibitor KIRA6 was administrated intranasally at 1 h after ICH, antagomiR‐25 and agomiR‐25 were injected intraventricularly at 24 h before ICH. Western blot analysis, RT‐qPCR, immunofluorescence staining, hematoma volume, neurobehavioral tests, dihydroethidium (DHE) staining, H2O2 content, brain water content, body weight, Hematoxylin and Eosin (HE) staining, Nissl staining, Morris Water Maze (MWM) and Elevated Plus Maze (EPM) were performed.ResultsEndogenous phosphorylated IRE1α (p‐IRE1α), miR‐25‐3p, and Nox4 were increased in the ICH model. Administration of KIRA6 downregulated miR‐25‐3p expression, upregulated Nox4 expression, promoted the level of oxidative stress, increased hematoma volume, exacerbated brain edema and neurological deficits, reduced body weight, aggravated spatial learning and memory deficits, and increased anxiety levels. Then antagomiR‐25 further upregulated the expression of Nox4, promoted the level of oxidative stress, increased hematoma volume, exacerbated brain edema and neurological deficits, whereas agomiR‐25 reversed the effects promoted by KIRA6.ConclusionThe IRE1α phosphokinase activity is involved in the oxidative stress response through miR‐25/Nox4 pathway in the mouse ICH brain.
Transient receptor potential vanilloid 1: A potential therapeutic target for the treatment of osteoarthritis and rheumatoid arthritis
Authors: Liao Zhidong , Umar Muhammad , Huang Xingyun , Qin Ling , Xiao Guozhi , Chen Yan , Tong Liping , Chen Di 
Published: November 2023

AbstractThis study aims to determine the molecular mechanisms and analgesic effects of transient receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid arthritis (RA). We summarize and analyse current studies regarding the biological functions and mechanisms of TRPV1 in arthritis. We search and analyse the related literature in Google Scholar, Web of Science and PubMed databases from inception to September 2023 through the multi‐combination of keywords like ‘TRPV1’, ‘ion channel’, ‘osteoarthritis’, ‘rheumatoid arthritis’ and ‘pain’. TRPV1 plays a crucial role in regulating downstream gene expression and maintaining cellular function and homeostasis, especially in chondrocytes, synovial fibroblasts, macrophages and osteoclasts. In addition, TRPV1 is located in sensory nerve endings and plays an important role in nerve sensitization, defunctionalization or central sensitization. TRPV1 is a non‐selective cation channel protein. Extensive evidence in recent years has established the significant involvement of TRPV1 in the development of arthritis pain and inflammation, positioning it as a promising therapeutic target for arthritis. TRPV1 likely represents a feasible therapeutic target for the treatment of OA and RA.
Epidemiology of acute infections in people who inject drugs in Australia
Authors: Attwood Lucy O. , O'Keefe Daniel , Higgs Peter , Vujovic Olga , Doyle Joseph S. , Stewardson Andrew J. 
Published: November 2023

AbstractIssuesPeople who inject drugs are at risk of acute infections, such as skin and soft tissue infections, infective endocarditis, bone and joint infections and bloodstream infections. There has been an increase in these infections in people who inject drugs internationally over the past 10 years. However, the local data regarding acute infections in Australia has not been well described.ApproachWe review the epidemiology of acute infections and associated morbidity and mortality amongst people who inject drugs in Australia. We summarise risk factors for these infections, including the concurrent social and psychological determinants of health.Key FindingsThe proportion of people who report having injected drugs in the prior 12 months in Australia has decreased over the past 18 years. However, there has been an increase in the burden of acute infections in this population. This increase is driven largely by skin and soft tissue infections. People who inject drugs often have multiple conflicting priorities that can delay engagement in care.ImplicationsAcute infections in people who inject drugs are associated with significant morbidity and mortality. Acute infections contribute to significant bed days, surgical requirements and health‐care costs in Australia. The increase in these infections is likely due to a complex interplay of microbiological, individual, social and environmental factors.ConclusionAcute infections in people who inject drugs in Australia represent a significant burden to both patients and health‐care systems. Flexible health‐care models, such as low‐threshold wound clinics, would help directly target, and address early interventions, for these infections.
Genomic evidence for climatic adaptation in Fejervarya multistriata
Authors: Lei Zhaoxia , Yan Chaochao , Jin Long , Li Jiatang , Yan Chengzhi , Liao Wenbo 
Published: November 2023

AbstractAimGenetic diversity driven by natural selection contributes to population divergence in amphibians, thus facilitating local adaptation to climate change. Understanding the mechanisms of genetic adaptation is one of the important issues in evolutionary biology. This study set out to reveal drivers responsible for intraspecific divergence in Fejervarya multistriata and further investigate the potential involvement of selected genes in responding to climate challenges.LocationChina.MethodTo identify adaptive traits associated with climate change, we conducted genome RAD‐seq of 300 F. multistriata individuals from 15 locations across a bio‐geographical range with gradual climatic variation in China.ResultsThe results indicate a substantial genetic diversity among populations of F. multistriata and highlight specific genes and pathways that likely contribute to intraspecific divergence. The demographic history of F. multistriata can be traced back to the last interglacial period, during which elevated temperatures may have led to a significant decline in effective population size. The analysis of genome‐climate association identified five candidate genes (BMP2K, NRAP, ZW10, MYH1 and PLB1) potentially involved in local climate adaptation.Main ConclusionsOur findings have shed light on the genetic mechanisms of local adaptation to climate change in F. multistriata, thereby aiding in determining the possible fate of populations under future climate change.
Longitudinal caregiver‐reported motor development in infants born at term and preterm
Authors: Warschausky Seth , Gidley Larson Jennifer C. , Raghunathan Trivellore , Berglund Patricia , Huth‐Bocks Alissa , Taylor H. Gerry , Staples Angela D. , Lukomski Angela , Barks John , Lajiness‐O'Neill Renee ,   the PediaTrac Project Consortium
Published: November 2023

AbstractAimTo examine the extent to which estimates of a latent trait or underlying construct of motor ability differ in infants born at term and preterm, based on caregiver ratings of the motor domain of PediaTrac v3.0.MethodThe sample consisted of 571 caregiver–infant dyads (331 born at term, 240 born preterm), 48% female, with 51.7% of caregivers identifying as an ethnic minority. Latent trait of motor ability was estimated based on item response theory modeling. Gestational group differences (term and preterm birth) were examined at the newborn/term‐equivalent, 2‐, 4‐, 6‐, 9‐, and 12‐month time points.ResultsCaregiver ratings of latent trait of motor ability were reliably modeled across the range of abilities at each time point. While the group born preterm exhibited significantly more advanced motor abilities at the term‐equivalent time point, by 6 months the group born at term was more advanced. Biological sex difference main and interaction effects were not significant.InterpretationCaregivers provided reliable, longitudinal estimates of motor ability in infancy, reflecting important differences in the motor development of infants born at term and preterm. The findings suggest that significant motor development occurs in infants born preterm from birth to the term‐equivalent time point and provide a foundation to examine motor growth trajectories as potential predictors in the early identification of neurodevelopmental conditions and needs.What this paper adds

Longitudinal caregiver ratings of motor function in early infancy yielded reliable estimates of the latent trait of motor ability.
Motor ability at the term‐equivalent time point was higher in infants born preterm than infants born at term.