bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present
Authors: Rosalki Sidney B , Roberts Robert , Katus Hugo A , Giannitsis Evangelos , Ladenson Jack H , Apple Fred S 
Published: October 2004

AbstractEditor’s Note: With great pleasure and anticipation in recognition of Clinical Chemistry’s 50th anniversary, I have been able to arm-twist four talented scientists to document their impressive marks on the science of diagnostics in the field of cardiac biomarkers and detection of myocardial infarction. Their exciting discoveries and applications have dramatically influenced the fields of laboratory medicine and cardiology and have greatly influenced the care and management of thousands of patients suffering from coronary artery disease leading to acute myocardial infarction. As a matter of historical record, I owe a great deal of thanks to each one of the coauthors of this special report because each one has personally influenced my scientific career. I met Dr. Rosalki, during my postdoctoral training, at a national AACC meeting, where he kindly answered my numerous queries regarding creatine kinase enzymology and muscle physiology. Dr. Roberts, while serving as Director of the Coronary Care Unit at Washington University in St. Louis, generously allowed this fledgling fellow into his laboratory and shared many of his clinical and experimental findings with me. Dr. Katus, whom I first met at a scientific meeting sponsored by Boehringer Mannheim in 1986 in Bavaria, where I first became fascinated with cardiac troponin T, has remained a friend and colleague. Lastly, Dr. Ladenson, who as mentor, scientific colleague, and close friend remains ultimately responsible for both my professional growth as a clinical chemist (he was my postdoctoral fellowship advisor) and for stimulating and encouraging my goals and aspirations in the field of cardiac biomarkers. With the descriptions of the ground-breaking science described below, I am extremely excited and optimistic that the future of cardiac biomarkers is secure and open to new discoveries by the Rosalkis, Robertses, Katuses, and Ladensons of the future.—Fred Apple
Yeast and Bacteria as Biological Control Agents Against Fungal Discolouration of Pinus sylvestris Blocks in Laboratory-Based Tests and the Role of Antifungal Volatiles
Authors: Payne C. , Bruce A. , Staines H. 
Published: October 2004

Summary
This paper reports on the use of yeast as biological control agents against mould and blue-stain fungi in
laboratory-based Pinus sylvestris sapwood wood block incubation tests. All 5 yeast isolates tested significantly
reduced discolouration of wood surfaces by moulds and most were also effective against staining
fungi. The 2 most promising yeast isolates also significantly reduced radial growth of selected mould
and stain fungi in vitro solely through the liberation of volatile compounds. Five bacterial isolates were
also tested for antagonism toward mould and stain fungi and were effective biological control agents in
wood block tests. Again, volatile production alone by the bacteria was shown to be sufficient to significantly
reduce fungal growth in vitro. Most of the bacteria and yeasts significantly reduced wood discolouration
by fungi when inoculated onto block surfaces 7 days before, or at the same time as the target
fungi, and in some cases even when inoculated 7 days after the fungi. The possibility of using yeasts
as biological control agents to prevent wood spoilage during kiln drying and short-term storage at
sawmills is considered.
Chromated Copper Arsenate Preservative Treatment of North American Hardwoods. Part 1. CCA Fixation Performance
Authors: Janezic T. Stevanovic , Cooper P.A. , Ung Y.T. 
Published: October 2004

Summary
We have examined chromated copper arsenate (CCA) wood preservative fixation at two selected temperatures
in seven common North American hardwood species: red maple (Acer rubrum L.), white birch
(Betula papyrifera Marsh.), yellow poplar (Liriodendron tulipifera L.), trembling aspen (Populus tremuloides
Michx.), red oak (Quercus rubra L.), basswood (Tilia americana L.) and American beech (Fagus
grandifolia Ehrh.). The softwood red pine (Pinus resinosa Ait.) was included for comparison. CCA component
fixation was monitored by the expressate method at both 21°C and 50°C under non-drying conditions.
Hexavalent chromium (CrVI) and total Cr, Cu and As contents of the expressate were determined
at different times during fixation. Based on CCA fixation results it was possible to divide the examined
hardwoods into a fast fixing group (beech, red oak and red maple), intermediate group (white birch and
red pine) and slow fixing group (aspen, yellow poplar and basswood). The variable fixation rates for the
different species could not be directly related to different anatomical and chemical attributes of the studied
hardwoods, although there was an apparent relationship with density with more dense species fixing
faster than low density species. However, the species differences appeared to be mainly influenced by
types and amounts of extractives in the woods. In red maple, extraction resulted in a slowing of the fixation
rate, while the opposite effect was seen in red oak.
Neolignan Skeletons and Benzodioxanes Through Chiral Aryl Alkyl Ether Formation
Authors: Li K. , Helm R.F. 
Published: October 2004

Summary
Several chiral neolignan skeletons and a benzodioxane were prepared from a tartrate derivative with the
crucial chiral aryl alkyl ether formation being accomplished with cesium phenolate and 18-crown-6.
These compounds have greater than 96% enantiomeric excess, and this work represents the first successful
synthetic preparation of optically active 8-O-4′ type neolignan skeletons. The chiral aryl alkyl
ethers were also synthesized from several protected carbohydrates, which can serve as chiral auxiliaries
for a wide variety of target molecules.
The Kismet of Residual During LMS Delignification of High-Kappa Kraft Pulps
Authors: Chakar F.S. , Ragauskas A.J. 
Published: October 2004

SummaryA series of laccase-mediator treatments (LMS) with 1-hydroxybenzotriazole (HBT) andN-acetyl-Nphenylhydroxylamine(NHAA) (Fig. 1) as the mediators were performed on a laboratory prepared southern softwood conventional kraft pulp (kappa # 75.4). Subsequent to the LMS treatments, the treated pulps were subjected to various oxidatively reinforced alkaline extraction stages (E*). The kappa results suggested that both LMSHBTand LMSNHAAtreatments delignified this high-kappa pulp. The E* stages were beneficial in countering the darkening effect observed after the LMS treatments. Structural changes in residual lignins isolated before and after laccase-mediator (LMSNHAA(E*) and LMSHBT(E*)) treatments were explored. The spectral analysis of phosphitylated residual lignins revealed an increase in carboxylic acid content and a depletion of phenolic hydroxyl groups in non-condensed at C-5 lignin moieties. Aliphatic hydroxyl groups were substantially decreased when NHAA was used. Overall, it appears that LMSHBTand LMsNHAAtreatments on high-kappa kraft pulps primarily attack phenolic hydroxyl groups in non-condensed at C-5 lignin structures.
Strain Changes on the Inner Bark Surface of an Inclined Coniferous Sapling Producing Compression Wood
Authors: Yoshida M. , Yamamoto O. , Okuyama T. 
Published: October 2004

Summary
The tangential strain on the inner bark of Cryptomeria japonica saplings grown in a growth chamber was
continuously measured using strain gauges. Compression wood formation was induced by artificial
inclination. The diurnal changes in tangential strain during light/dark cycles in the growth chamber differed
from those observed in the field. The total strain increased daily, increasing incrementally during
dark periods and decreasing in the light, as observed in the field. In the growth chamber, however, steep
increases and rapid decreases in strain were found immediately following lights-off and lights-on. In the
inclined saplings, the strain increased more on the lower side of the stem than on the upper side; and the
increment of the strain in the dark and the decrement in the light were larger on the lower side than on
the upper side. The change in tangential strain on the inner bark surface arises from changes in the volume
of differentiating cells, corresponding to turgor pressure changes and cell-wall extensibility
changes. Therefore, the differentiating tracheids into compression wood appear to expand at night and
shrink in the daytime more than the differentiating tracheids into normal wood.
Nanoporous Dna Field Effect Transistor with Potential for Random‐Access Memory Applications: A Selectivity Performance Evaluation
Authors: Kilinc Volkan , Hayakawa Ryoma , Yamauchi Yusuke , Wakayama Yutaka , Hill Jonathan P. 
Published: February 2024

AbstractMethods to encode digital data items as strands of synthetic DNA followed by selective data retrieval have been demonstrated. However, these initially bio‐oriented processes remain slow and not optimized. DNA field‐effect transistor (DNA‐FET) is studied here as a possible random‐access memory (RAM) device for simple, selective and rapid ssDNA fragment retrieval used as data pool identifier. The DNA‐FET is based on a co‐planar Au‐gated fully organic transistor appended with short single‐stranded DNA (ssDNA) probes bearing a blocking molecule to prevent partial hybridization and achieve near perfect selectivity for short length ssDNA (up to 45 nt). Examination of transconductance of the novel active layer incorporating a DNA nanopore architecture reveals enhanced binding site accessibility. This, in turn, facilitates discriminatory hybridization, particularly in the physical retrieval of short‐length ssDNA from a competitive, concentrated ssDNA background pool consisting of nine different sequences, with at least one nucleotide difference. The DNA‐FET exhibits rapid operation (9 min) in the millivolt range, low detection limit (sub‐femtomolar), high selectivity and reusability. Considering the straightforward concept, near error‐free identification capacity and hypothetically outstanding scalability, the DNA‐FET described here has potential as a foundation for further exploration of advanced RAM technology in the DNA data storage process.
ZSM‐5 zeolite incorporated flow battery membranes with regulated pore channels for high proton conduction
Authors: Cai Yekai , Lin Shuhao , Xia Yu , Hou Qingming , Lu Yuqin , Cao Hongyan , Wang Yixing , Huang Kang , Xu Zhi 
Published: February 2024

AbstractFast proton conduction plays an essential role in ion conductive membranes (ICMs) for energy conversion and storage technologies, but the demand for low reactive species permeation always limits further enhancement in proton transport rate. Herein, an ICM incorporating ZSM‐5 zeolite with optimized physicochemical property of pore channels was developed to achieve highly conductive ion transport via regulating the silicon‐aluminum atomic (Si/Al) ratio of ZSM‐5. Benefiting from the regulation of pore channels of zeolites, the proton conductivity of the pristine membrane was remarkably improved to 1.7‐fold. As expected, the optimized membrane exhibited outstanding voltage efficiency (VE) of 85.7% and energy efficiency (EE) of 85.1% at 120 mA/cm2, which is considerably better than pure polymer membrane (VE of 80.5% and EE of 79.4%) and commercial Nafion 212 (VE of 81.3% and EE of 77.4%) membrane, respectively.
Nontargeted metabolomics reveals sequential changes in amino acid and ferroptosis‐related metabolism in Parkinson's disease
Authors: Xu Delai , Dai Jing , Tang Liuxing , Pan Jie , Zhang Hua 
Published: February 2024

AbstractParkinson's disease (PD) is inseparable from metabolic disorders but lacks assessment of specific metabolite alteration. To explore the sequential metabolic changes in PD progression, we evenly divided 78 C57BL/6 mice (10 weeks) into six groups (one control group and five experimental groups) and collected the hippocampus tissue of mice after treating with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine, and probenecid (twice a week) at five periods (1, 2, 3, 4, and 5 weeks) for metabolome analysis. Our study identified 567 differentially abundant metabolites (DAMs) (total 4348 metabolites). Compared with controls, 145, 146, 171, 208, and 213 DAMs were obtained from the five experimental groups, respectively. Notably, 40 shared DAMs were present in five experimental groups, of which 22 shared DAMs formed a new metabolic network based on amino acid metabolism. Compared with group W3, 84 DAMs were identified in group W5, including 12 unique DAMs. DAMs in different stages of PD were significantly enriched in amino acid metabolism pathway, lipid metabolism pathway, and ferroptosis pathway. l‐Glutamine, spermidine, and l‐tryptophan were the key hubs in the whole metabolic process of PD. N‐Formyl‐l‐methionine gradually increased in abundance with PD progression, whereas 5‐methylcytosine gradually decreased. The study emphasized the sequential changes in DAMs in PD progression, stimulating subsequent studies.
Double‐input triple‐output non‐isolated DC–DC converter based on coupled inductor with high step‐up output voltages
Authors: Saadatizadeh Zahra , Babaei Ebrahim , Hosseini Seyed Hossein 
Published: February 2024

SummaryThis paper introduces a new non‐isolated double‐input triple‐output (DITO) high voltage gain DC–DC converter with a wide range of applications, including hybrid voltage source systems, solar home appliances, DC‐bus power distribution systems, and electrical vehicles (EVs). The proposed DITO converter interfaces two hybrid voltage sources to supply three different output loads with varying voltage and power levels. Compared to conventional converters of the same type, the proposed DITO converter offers several advantages, including operation for all duty cycles, integration of hybrid energy sources to transfer power to multiple loads, high voltage conversion ratio for all three‐output ports, a higher ratio of total voltage gain to total components number, common grounded input and output DC ports, simultaneous DC voltage regulation of three‐output ports by tuning separate controlling parameters of duty cycles, an additional turns ratio of coupled inductors to increase the voltage gain of output ports, and medium voltage stress on switches. The proposed DITO converter utilizes a new single‐switch single‐coupled‐inductor DC–DC structure, which is analyzed and verified through a prototype implementation for 25 and 30 V input voltages and 210, 330, and 400 V output voltages with a total power of 480 W. The experimental results confirm the simulation results and theoretical analysis.
Coupled inductor‐based buck power factor correction (PFC) converter with soft switching
Authors: Ortatepe Zafer , Karaarslan Ahmet , Akgül Hüseyin 
Published: February 2024

SummaryIn this study, couple inductor‐based buck power factor correction (PFC) converter is designed to mitigate dead zones of the converter. To minimize switching losses, all switches are controlled using a soft switching method, eliminating the need for snubber circuits. The circuit is controlled by an analog UC3843 pulse width modulation (PWM) integrated circuit (IC), providing natural PFC capability, which simplifies control and offers advantages in terms of size and cost compared to conventional ones. Simulation studies and prototype implementation are carried out to evaluate performance of the topology. The converter operates within a voltage range of 90–280 Vrms and has a power rating of 150 W. The results from both simulation and experimental analyses indicate that power factor (PF) of the circuit exceeds 98% and total harmonic distortion (THD) of the input current is found to be below 5% under various input voltage and load conditions. Furthermore, proposed topology demonstrated high efficiency, with measurements of 93% at full load and 95.6% at half load under 220 Vrms input voltage and 80 Vdc output voltage conditions. Outcomes highlight that the proposed topology achieves pure sinusoidal input current and exhibits competitive performance compared to other topologies used in the industry.
Application of geochemical tracers for the investigations of groundwater resources in semi‐arid region (Central‐East Tunisia)
Authors: Gammoudi Amal , Trabelsi Rim , Zouari Kamel 
Published: February 2024

AbstractGroundwater resources in Mahdia‐Ksour Essef region, located in the central‐eastern part of Tunisia, suffer from intensive exploitation and degradation of water quality. The assessment of groundwater vulnerability, the well‐understanding of geochemical processes and the investigation of groundwater quality variations are of particular importance for water resources management in this semi‐arid region. The results of this multi‐disciplinary investigation show that groundwaters of Mahdia‐Ksour Essef region are flowing from El Jem and Boumerdes regions in the South, towards the Mediterranean Sea and the sebkha of Moknine in the North. The groundwaters are classified as either Na‐Cl or Ca‐SO4. Stable oxygen and hydrogen isotope compositions (δ18O and δ2H) confirm a recharge by rapid water infiltration, evaporate surface water and water‐rock interaction processes in the salinity increase. The rock‐water interaction processes of the mineralization of groundwaters include the cation‐exchange reactions and the dissolution of carbonates and evaporate. The high values of the water quality index (WQI) and of the total dissolved solids (TDS) (3.7–11 g/L) of these groundwaters indicate their unsuitability for drinking purpose. Moreover, the combination of the WQI, TDS and nitrate results prove the vulnerability of the studied groundwater to the anthropogenic pollution linked to agriculture and domestic activities and to the salt water contamination.
What do we need in order to successfully treat persons with pathological narcissism? How does change happen? Treatment principles and mechanisms of change emerging from single cases treated by experts: A commentary
Authors: Dimaggio Giancarlo , Weinberg Igor 
Published: February 2024

AbstractPersons with pathological narcissism (PN) or narcissistic personality disorder present with a wide array of symptoms and social problems. They need effective psychotherapies but empirical evidence for what works with them is mostly lacking. In this issue of the Journal and Clinical Psychology: In Session four authors from different orientations described single cases of patients suffering from different manifestations of PN. In this commentary we reviewed in detail the four cases and tried to distill (a) the treatment principles adopted; (b) the actual mechanisms of therapeutic change. We hope that the list of principles and mechanisms and change we identified here can help both clinicians and researchers develop and test effective options for persons with PN who are difficult to treat but do have chances to change in a meaningful way in treatment.
UBC9‐mediated SUMOylation of Lamin B1 enhances DNA‐damage‐induced nuclear DNA leakage and autophagy after spinal cord injury
Authors: Fan Yun‐peng , Lou Jun‐sheng , Jin Meng‐ran , Zhou Cong‐hui , Shen Hong‐hao , Fu Chun‐yan , Mao Xing‐jia , Chen Ying‐ying , Zhong Jin‐jie , Wang Lin‐lin , Wu Jun‐song 
Published: February 2024

AbstractRecent studies have shown that nucleophagy can mitigate DNA damage by selectively degrading nuclear components protruding from the nucleus. However, little is known about the role of nucleophagy in neurons after spinal cord injury (SCI). Western blot analysis and immunofluorescence were performed to evaluate the nucleophagy after nuclear DNA damage and leakage in SCI neurons in vivo and NSC34 expression in primary neurons cultured with oxygen–glucose deprivation (OGD) in vitro, as well as the interaction and colocalization of autophagy protein LC3 with nuclear lamina protein Lamin B1. The effect of UBC9, a Small ubiquitin‐related modifier (SUMO) E2 ligase, on Lamin B1 SUMOylation and nucleophagy was examined by siRNA transfection or 2‐D08 (a small‐molecule inhibitor of UBC9), immunoprecipitation, and immunofluorescence. In SCI and OGD injured NSC34 or primary cultured neurons, neuronal nuclear DNA damage induced the SUMOylation of Lamin B1, which was required by the nuclear Lamina accumulation of UBC9. Furthermore, LC3/Atg8, an autophagy‐related protein, directly bound to SUMOylated Lamin B1, and delivered Lamin B1 to the lysosome. Knockdown or suppression of UBC9 with siRNA or 2‐D08 inhibited SUMOylation of Lamin B1 and subsequent nucleophagy and protected against neuronal death. Upon neuronal DNA damage and leakage after SCI, SUMOylation of Lamin B1 is induced by nuclear Lamina accumulation of UBC9. Furthermore, it promotes LC3‐Lamin B1 interaction to trigger nucleophagy that protects against neuronal DNA damage.
Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans
Authors: Wang Lin , Li Peiyu , Zheng Fuping , Zhu Zhiling , Bai Fan , Gao Ruichang 
Published: February 2024

AbstractBACKGROUNDSturgeon is a popular aquaculture species in many countries. Its swim bladder is rich in collagen but has not yet been exploited scientifically.RESULTSCollagen peptides (CPs) prepared from sturgeon swim bladder by trypsinolysis had an average molecular weight of 528.5 Da and consisted of 407 peptides, 16.1% of the content of which was GFPGADGSAGPK. The CPs at 25 mg mL‐1 extended the lifespan of Caenorhabditis elegans by 22.6%, which was significantly higher than the extension achieved by other hydrolysis methods and source materials. They also improved fitness‐related traits (body size, motor capacity, oxidative stress, cell apoptosis, and epidermal barrier function), indicating prolonged healthspan. Transcriptome analysis showed that the effect was mediated by the mitogen‐activated protein kinase pathway, which enhanced stress resistance, the insulin/IGF‐1 pathway, which inhibited protein aggregation, and the NHR‐80/FAT‐6 pathway, which regulated lipid metabolism.CONCLUSIONCollagen peptides from sturgeon swim bladder by trypsinolysis prolonged the lifespan and healthspan in C. elegans, and might be promising anti‐aging agents. © 2024 Society of Chemical Industry.
Partial Replacement of NaCl with KCl in Cooked Meat Could Reduce the Liver Damage Through Renin–Angiotensin System in Mice
Authors: Zou Lifang , Yu Xia , Xiong Jiahao , Chen Conggui , Xiao Guiran 
Published: February 2024

ScopeDietary salt (sodium chloride, NaCl) is necessary for processed meat products, but intake of a high‐sodium diet carries serious health risks. Considerable studies indicate that the partial substitution of NaCl with potassium chloride (KCl) can produce sodium‐reduced cooked meat. However, most studies of sodium‐reduced cooked meat focus on the production process in vitro, and the effect of cooked meat on health has not been well clarified in vivo.Methods and resultsThis study finds that compared to the high‐sodium group (HS), serum renin, angiotensin‐converting enzyme (ACE), angiotensin (Ang) II, and the levels of some indicators of dyslipidemia are decreased in the reduced salt by partial substitution of NaCl with KCl group (RS + K). Furthermore, RS + K increases the antioxidation abilities, inhibits the renin–angiotensin system (RAS) through ACE/Ang II/Ang II type 1 receptor axis pathway, reduces synthesis of triglyceride and cholesterol and protein expressions of inflammatory factors interleukin‐17A and nuclear factor‐kappa B in the liver.ConclusionPartial substitution of NaCl with KCl in cooked meat can be a feasible approach for improving the health benefits and developing novel functional meat products for nutritional health interventions.