bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RRI Citizen Review Panel: a public engagement method for supporting responsible territorial policymaking
Authors: Bidstrup Maya Vestergaard , Gabova Snezhina , Kilintzis Pavlos , Samara Elpida , Kouskoura Amalia , Bakouros Yiannis , Roth Florian 
Published: January 2024

AbstractResponsible Territorial Policymaking incorporates the main principles of Responsible Research and Innovation (RRI) into the policymaking process, making it well-suited for guiding the development of sustainable and resilient territorial policies that prioritise societal needs. As a cornerstone in RRI, public engagement plays a central role in this process, underscoring the importance of involving all societal actors to align outcomes with the needs, expectations, and values of society. In the absence of existing methods to gather sufficiently and effectively the citizens’ review of multiple policies at a territorial level, the RRI Citizen Review Panel is a new public engagement method developed to facilitate citizens’ review and validation of territorial policies. By using RRI as an analytical framework, this paper examines whether the RRI Citizen Review Panel can support Responsible Territorial Policymaking, not only by incorporating citizens’ perspectives into territorial policymaking, but also by making policies more responsible. The paper demonstrates that in the review of territorial policies, citizens are adding elements of RRI to a wide range of policies within different policy areas, contributing to making policies more responsible. Consequently, the RRI Citizen Review Panel emerges as a valuable tool for policymakers, enabling them to gather citizen perspectives and imbue policies with a heightened sense of responsibility.
Study on Crack Resistance and Calculation Model of RAC Beams Strengthened with Prestressed CFRP
Authors: Ji Yanting , Sun Sheng , Chen Aijiu , Yang Fen , Bai Shihua , Han Xiaoyan 
Published: January 2024

AbstractWith the development of recycled aggregate concrete (RAC), the recovery rate of construction waste is improved, and the pollution problem is alleviated. In particular, RAC beams strengthened with prestressed carbon fiber reinforced plastics (CFRP) can exhibit improved mechanical properties, expanding RAC application. Four groups of reinforced RAC beam specimens contained 0%, 40%, 70%, and 100% recycled coarse aggregate, respectively. Each group of beams was first pre-cracked and then strengthened by prestressed CFRP with one layer and two layers respectively. Finally, the bearing capacity tests were performed for these beams. The test results show that as the recycled coarse aggregate content increases, the cracking moment and ultimate load capacity of the beam decrease, while its crack width increases. As the CFRP layer increases, the deformation and crack width of the beam decreases, while the number of cracks increases. The prestressed CFRP also exhibited tensile and peeling failure. A beam deflection calculation model was established by introducing a coefficient k representing the interaction between recycled aggregate and CFRP. The influence coefficient of concrete elongation on the crack width and average crack spacing of the beam was modified, and the crack width analysis model of the beam was established. The calculated results are in good agreement with the experimental observations. It can provide reference for the application and design of recycled concrete beams strengthened with prestressed CFRP.
How do professionals and non-professionals respond to non-suicidal self-injury? Lived experiences of psychiatric outpatients in Singapore
Authors: Tan Rachel Hsiao Shen , Shahwan Shazana , Zhang Yunjue , Sambasivam Rajeswari , Ong Say How , Subramaniam Mythily 
Published: January 2024

Abstract
Background
For young people who engage in non-suicidal self-injury (NSSI), receiving negative responses to their NSSI can pose a barrier to future help-seeking. This qualitative study aimed to explore helpful and unhelpful ways in which professionals and non-professionals respond to NSSI, from the perspectives of individuals with lived experiences of NSSI.

Methods
Semi-structured interviews were conducted with 20 outpatients (6 males, 14 females) aged 17 to 29 years from a tertiary psychiatric hospital in Singapore, who had reported engaging in NSSI behavior in an earlier study. The interviews were audio recorded and transcribed verbatim. Thematic analysis was used to identify themes and subthemes in the data.

Results
Professionals’ responses were organized into three main themes: ‘prescribing solutions without understanding needs’, ‘disapproval or judgment’, and ‘helpful responses’. Non-professionals’ responses were organized into four main themes: ‘emotionally charged responses’, ‘avoidance and inaction’, ‘poor understanding of reasons for NSSI’, and ‘providing tangible support and acknowledging NSSI’. Participants also described how unhelpful responses negatively impacted their willingness to seek help.

Conclusions
Our findings provide a better understanding of responses to NSSI that are considered helpful and unhelpful, and can be used to improve existing guidelines on responding to NSSI.
SnO2 nanostructure-based acetone sensors for breath analysis
Authors: Shanmugasundaram Arunkumar , Munirathinam Karthikeyan , Lee Dong-Weon 
Published: January 2024

AbstractThe World Health Organization reports that metabolic disorders are responsible for a significant proportion of global mortality. Considering this, breath sensors have gained prominence as effective tools for monitoring and diagnosing metabolic disorders, thanks to recent advancements in science and technology. In human exhaled breath, over 870 distinct volatile organic components (VOCs) have been identified. Among several VOCs, the detection of acetone in exhaled breath has received considerable attention in biomedical applications. Research indicates a strong correlation between high acetone levels in human breath and several diseases, such as asthma, halitosis, lung cancer, and diabetes mellitus. For instance, acetone is particularly noteworthy as a biomarker in diabetes, where its concentration in exhaled breath often surpasses 1.76 parts per million (ppm), compared to less than 0.8 ppm in healthy individuals. Early diagnosis and intervention in diseases associated with elevated acetone levels, aided by such non-invasive techniques, have the potential to markedly reduce both mortality and the financial burden of healthcare. Over time, various nanostructured gas sensing technologies have been developed for detecting acetone in both ambient air and exhaled breath. This article presents a mini review of cutting-edge research on acetone gas sensing, focusing specifically on nanostructured metal oxides. It discusses critical factors influencing the performance of acetone gas sensors, including acetone concentration levels and operational temperature, which affect their sensitivity, selectivity, and response times. The aim of this review is to encourage further advancements in the development of high-performance acetone gas sensors utilizing nanostructured materials, contributing to more effective management of metabolic disorders.
Antioxidant and antimicrobial activities of lignin-derived products from all steam-exploded palm oil mill lignocellulosic biomass waste
Authors: Sholahuddin Sholahuddin , Arinawati Dian Yosi , Nathan Vinod Kumar , Asada Chikako , Nakamura Yoshitoshi 
Published: January 2024

Abstract
Background
Steam explosion pretreatment has been proven to be an effective treatment for breaking down the recalcitrant character of lignin–carbohydrate complexes (LCC) in lignocellulosic biomass. This study investigated the production of lignin-derived products from steam-exploded palm oil mill lignocellulosic biomass waste (POMLBW), that is, empty fruit bunches (EFB), kernel shells (KS), and kernel fibers (KF), also known as mesocarp fibers. Steam explosions cause lignin depolymerization, which forms various polyphenols. The low average molecular weight of the steam-exploded lignin-derived products and their antioxidant activities could potentially enhance their antimicrobial activities.

Methods
POMLBW was steam-exploded with various degrees of severity factors (R0: 4.03, 4.91, 5.12, 5.35, and 5.65). Steam-exploded POMLBW produces lignin-derived products such as low-molecular-weight lignin (LML) and water-soluble lignin (WSL). Antioxidant activity was evaluated using 0.5 mM 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Polyphenol content was evaluated using the Folin–Ciocalteu method. The antimicrobial activity was evaluated using an agar diffusion assay with Gram-positive and Gram-negative bacteria, and the thermal characteristics were evaluated using differential scanning calorimetry and thermogravimetric analysis.

Results
WSL and LML resulted in high radical scavenging activity (RSA) of approximately 95% and 80%, with 0.25 g/L and 0.5 g/L of EC50, where the polyphenol amount was 242–448 mg/g (catechin eq.) and 20–117 mg/g (catechin eq.) under all LML and WSL conditions, respectively. The steam-exploded POMLBW had an average molecular weight of 1589–2832 Da, and this condition, including high RSA and polyphenol amounts, was responsible for the high antimicrobial activities of LML against both Gram-positive (Salmonella enterica, Pseudomonas aeruginosa, and Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Additionally, the thermal properties investigations revealed that the glass transition temperature was 80–90 °C (Tg), the melting temperature (Tm) was 338–362 °C, and the start temperature was 101–128 °C at the beginning of mass loss.

Conclusions
These results show that the lignin-derived product from steam-exploded POMLBW has the potential for antioxidant (LML and WSL) and antimicrobial (LML) applications with good thermal resistance.

Graphical Abstract
Estimating hourly surface shortwave radiation over northeast of the Tibetan Plateau by assimilating Himawari-8 cloud optical thickness
Authors: Zhang Tianyu , Letu Husi , Dai Tie , Shi Chong , Lei Yonghui , Peng Yiran , Lin Yanluan , Chen Liangfu , Shi Jiancheng , Tian Wei , Shi Guangyu 
Published: January 2024

AbstractTo reduce the uncertainty estimation of clouds and improve the forecast of surface shortwave radiation (SSR) over the Tibetan Plateau, a new cloud assimilation system is proposed which is the first attempt to directly apply the four-dimensional local ensemble transform Kalman filter method to assimilate the cloud optical thickness (COT). The high-resolution spatial and temporal data assimilated from the next-generation geostationary satellite Himawari-8, with the high-assimilation frequency, realized an accurate estimation of the clouds and radiation forecasting. The COT and SSR were significantly improved after the assimilation by independent verification. The correlation coefficient (CORR) of the SSR was increased by 11.3%, and the root-mean-square error (RMSE) and mean bias error (MBE) were decreased by 28.5% and 58.9%, respectively. The 2-h cycle assimilation forecast results show that the overestimation of SSR has been effectively reduced using the assimilation system. These findings demonstrate the high potential of this assimilation technique in forecasting of SSR in numerical weather prediction. The ultimate goal that to improve the model forecast through the assimilation of cloud properties requires further studies to achieve.
Have the extraordinary circumstances of the COVID-19 outbreak and the Russian–Ukrainian conflict impacted the efficiency of cryptocurrencies?
Authors: Maghyereh Aktham , Al-Shboul Mohammad 
Published: January 2024

AbstractThis study explores whether the COVID-19 outbreak and Russian–Ukrainian (R–U) conflict have impacted the efficiency of cryptocurrencies. The novelty of this study is the use of the Cramér-von Mises test to examine cryptocurrency efficiency. We used a sample of daily prices for the six largest cryptocurrencies, covering the period from September 11, 2017, to September 30, 2022. Cryptocurrencies are found to be weakly efficient but exhibit heterogeneous levels of efficiency across currencies. Extraordinary events (COVID-19 and R–U) play a vital role in the degree of efficiency, where a trend toward inefficiency appears in all cryptocurrencies except for Ethereum Classic and Ripple. During the COVID-19 pandemic, the degree of inefficiency was higher than the level of inefficiency during R–U. This study provides useful guidance for investors and portfolio diversifiers to adjust their asset allocations during normal and stressful market periods.
Posterior lumbar interbody fusion using single PEEK cage without pedicle screw fixation for lumbar disc herniation; Initial experience in Menoufia University Hospital
Authors: Elnaggar Ahmed Gabry , Elsisi Yasser Bahgat , Shereef Osama Saber 
Published: January 2024

AbstractBackgroundLumbar discectomy has successful initial clinical outcome; its long-term success rate decreases to 40–80% due to chronic low back pain and recurrent disc herniation.ObjectiveTo evaluate the clinical results of Posterior Lumbar Interbody Fusion with a single unilateral stand-alone PEEK (Poly-Ether-Ether-Ketone) cage without pedicle screw fixation for single level lumbar disc herniation.MethodsA retrospective study of 40 patients (24 men and 16 women) with lumbar disc herniation, was conducted in the period from January 2016 through January 2021. The follow-up continued till December 2021. All patients suffered from single level lumbar disc herniation and were treated with Posterior Lumbar Interbody Fusion with a single unilateral stand-alone PEEK cage without pedicle screw fixation.ResultsThe affected levels were L2–3 in 2 cases, L3–4 in 8 cases, L4–5 in 18 cases and L5–S1 in 12 cases. On 18th month follow-up, significant decrease in leg pain, LBP and ODI scores was detected (p< 0.001).ConclusionsThis technique produced satisfying clinical enhancement in residual LBP, accepted radiological outcome such as maintaining the proper intervertebral disc space and prevention of recurrent disc herniation.
Portal vein embolization following arterial portography for the management of an active portal bleeding after blunt liver trauma in a cirrhotic patient
Authors: L’Huillier Romain , Cayot Bénédicte , Turc Jean , Milot Laurent 
Published: January 2024

Abstract
Background
The management of blunt liver trauma in cirrhotic patients is challenging, because while bleeding is most often of arterial origin, the increased pressure in the portal system associated with cirrhosis can increase the risk of portal bleeding, which is sometimes difficult to confirm on contrast-enhanced abdominal computed tomography.

Case presentation
We managed a 54-year-old cirrhotic patient who presented with blunt liver trauma. Computed Tomography showed active intraperitoneal bleeding presumed to be of hepatic origin. Given the patient's hemodynamic stability, the decision was made to manage the patient non-surgically. The patient underwent hepatic arteriography to rule out an arterial origin to the bleeding. A superior mesenteric arterial portography confirmed the portal venous origin of the bleeding. To stop the bleeding, a distal portal vein embolization using coils and glue was performed by approaching a large paraumbilical vein.

Conclusions
Our case study shows the value of arterial portography in the management of these patients, when they are clinically stable enough to benefit from non-surgical management; This allows arterial bleeding to be excluded on hepatic arteriography, portal bleeding to be confirmed on portography following arteriography in the superior mesenteric artery, and guidance of portal vein embolization.
Simulating long-term wildfire impacts on boreal forest structure in Central Yakutia, Siberia, since the Last Glacial Maximum
Authors: Glückler Ramesh , Gloy Josias , Dietze Elisabeth , Herzschuh Ulrike , Kruse Stefan 
Published: January 2024

Abstract
Background
Wildfires are recognized as an important ecological component of larch-dominated boreal forests in eastern Siberia. However, long-term fire-vegetation dynamics in this unique environment are poorly understood. Recent paleoecological research suggests that intensifying fire regimes may induce millennial-scale shifts in forest structure and composition. This may, in turn, result in positive feedback on intensifying wildfires and permafrost degradation, apart from threatening human livelihoods. Most common fire-vegetation models do not explicitly include detailed individual-based tree population dynamics, but a focus on patterns of forest structure emerging from interactions among individual trees may provide a beneficial perspective on the impacts of changing fire regimes in eastern Siberia. To simulate these impacts on forest structure at millennial timescales, we apply the individual-based, spatially explicit vegetation model LAVESI-FIRE, expanded with a new fire module. Satellite-based fire observations along with fieldwork data were used to inform the implementation of wildfire occurrence and adjust model parameters.

Results
Simulations of annual forest development and wildfire activity at a study site in the Republic of Sakha (Yakutia) since the Last Glacial Maximum (c. 20,000 years BP) highlight the variable impacts of fire regimes on forest structure throughout time. Modeled annual fire probability and subsequent burned area in the Holocene compare well with a local reconstruction of charcoal influx in lake sediments. Wildfires can be followed by different forest regeneration pathways, depending on fire frequency and intensity and the pre-fire forest conditions. We find that medium-intensity wildfires at fire return intervals of 50 years or more benefit the dominance of fire-resisting Dahurian larch (Larix gmelinii (Rupr.) Rupr.), while stand-replacing fires tend to enable the establishment of evergreen conifers. Apart from post-fire mortality, wildfires modulate forest development mainly through competition effects and a reduction of the model’s litter layer.

Conclusion
With its fine-scale population dynamics, LAVESI-FIRE can serve as a highly localized, spatially explicit tool to understand the long-term impacts of boreal wildfires on forest structure and to better constrain interpretations of paleoecological reconstructions of fire activity.
The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases
Authors: Tao Min , Shi Yingfeng , Chen Hui , Li Jinqing , Wang Yi , Ma Xiaoyan , Du Lin , Wang Yishu , Yang Xinyu , Hu Yan , Zhou Xun , Zhong Qin , Yan Danying , Qiu Andong , Zhuang Shougang , Liu Na 
Published: January 2024

AbstractThe disruptor of telomeric silencing 1-like (DOT1L), a specific histone methyltransferase that catalyzed methylation of histone H3 on lysine 79, was associated with the pathogenesis of many diseases, but its role in peritoneal fibrosis remained unexplored. Here, we examined the role of DOT1L in the expression and activation of protein tyrosine kinases and development of peritoneal fibrosis. We found that a significant rise of DOT1L expression in the fibrotic peritoneum tissues from long-term PD patients and mice. Inhibition of DOT1L significantly attenuated the profibrotic phenotypic differentiation of mesothelial cells and macrophages, and alleviated peritoneal fibrosis. Mechanistically, RNA sequencing and proteomic analysis indicated that DOT1L was mainly involved in the processes of protein tyrosine kinase binding and extracellular matrix structural constituent in the peritoneum. Chromatin immunoprecipitation (ChIP) showed that intranuclear DOT1L guided H3K79me2 to upregulate EGFR in mesothelial cells and JAK3 in macrophages. Immunoprecipitation and immunofluorescence showed that extranuclear DOT1L could interact with EGFR and JAK3, and maintain the activated signaling pathways. In summary, DOT1L promoted the expression and activation of tyrosine kinases (EGFR in mesothelial cells and JAK3 in macrophages), promoting cells differentiate into profibrotic phenotype and thus peritoneal fibrosis. We provide the novel mechanism of dialysis-related peritoneal fibrosis (PF) and the new targets for clinical drug development. DOT1L inhibitor had the PF therapeutic potential.
Telemedicine use and decrements to type 2 diabetes and hypertension care during the COVID-19 pandemic
Authors: Rodriguez Hector P. , Ciemins Elizabeth , Rubio Karl , Rattelman Cori , Cuddeback John K. , Mohl Jeff T. , Bibi Salma , Shortell Stephen M. 
Published: January 2024

Abstract
Background
We examine pandemic-era quality of care changes associated with telemedicine use among adults with type 2 diabetes and/or hypertension across ten health systems.

Methods
Patient-level encounter and laboratory data (n = 1,963,563) were analyzed for pre-pandemic (March 13, 2019 to December 31, 2019) and pandemic (March 13, 2020 to December 31, 2020) periods. Generalized linear models with binomial distribution functions and log links estimated the association of telemedicine use with four outcomes: 1) hemoglobin A1c (HbA1c) testing, 2) HbA1c control (< 8.0%), 3) blood pressure (BP) testing, and 4) BP control (< 140 / 90 mmHg), controlling for patient characteristics, system fixed effects, and with propensity score weights.

Results
In adjusted analyses, telemedicine use was associated with lower odds of HbA1c (aOR = 0.74, p < 0.05) and BP (aOR = 0.40, p < 0.01) testing for adults with type 2 diabetes, but not HbA1c or BP control. Among hypertension-only patients, telemedicine use was associated with lower odds of BP testing (aOR = 0.10, p < 0.001), but not BP control. Compared to pre-pandemic telemedicine use, pandemic period telemedicine use was associated with lower odds of HbA1c and BP monitoring.

Discussion
Telemedicine use was associated with lower odds of HbA1c monitoring for adults with type 2 diabetes and lower odds of BP testing for adults with type 2 diabetes and/or hypertension.

Conclusion
As telemedicine continues to be used for diabetes and hypertension care, remote monitoring, standing orders, and community pharmacy partnerships may be necessary supplements to telemedicine to assure high quality care, especially when in-person care options are limited.
The process and perspective of serious incident investigations in adult community mental health services: integrative review and synthesis
Authors: Haylor Helen , Sparkes Tony , Armitage Gerry , Dawson-Jones Melanie , Double Keith , Edwards Lisa 
Published: January 2024

Aims and methodSerious incident management and organisational learning are international patient safety priorities. Little is known about the quality of suicide investigations and, in turn, the potential for organisational learning. Suicide risk assessment is acknowledged as a complex phenomenon, particularly in the context of adult community mental health services. Root cause analysis (RCA) is the dominant investigative approach, although the evidence base underpinning RCA is contested, with little attention paid to the patient in context and their cumulative risk over time.ResultsRecent literature proposes a Safety-II approach in response to the limitations of RCA. The importance of applying these approaches within a mental healthcare system that advocates a zero suicide framework, grounded in a restorative just culture, is highlighted.Clinical implicationsAlthough integrative reviews and syntheses have clear methodological limitations, this approach facilitates the management of a disparate body of work to advance a critical understanding of patient safety in adult community mental healthcare.