bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic Motivation of Master Students Studying Pedagogical Science: Case of KFU
Authors: Ibragimov G. I. , Kalimullina A. A. , Ibragimov M. G. 
Published: November 2023

The relevance of the study is due to the contradiction between the objective need for developing the academic motivation of Master students by means of research-oriented education and the insufficient development of the corresponding didactic conditions. The purpose of this paper is to identify the research-based learning potential in the development of Master students academic motivation and reasoning the didactic conditions promoting its effective implementation. In order to achieve it, the following tasks were solved: to reveal the essence of academic motivation and its features among Master’s students studying “Pedagogical science”; to promote theoretically and experimentally the didactic conditions for the effective implementation of the motivational potential of research-oriented learning. To identify the features of academic motivation, the methodology “Scale of Academic Motivation” was used.Research results: the essence of academic motivation as a set of motives that are the reason for the conscious inclusion of a student in educational activities is revealed; the features of the academic motivation of Master students studying Pedagogical science were revealed (the conscious choice of the program of training by the vast majority of students; different students’ background – previous education, work experience, age, that determines the polymotivation of educational activity with the dominance of internal motivation). It is shown that the motivational potential of researchoriented teaching of students is associated with its main characteristics: the purpose, content, nature of studying and research activities, features of results evaluation. Didactic conditions were experimentally promoted that enhance the motivational potential of research-oriented learning (taking into account the characteristics and levels of development of the corresponding types of students’ motivation; creating real opportunities for free choice of research topics for Master students; using work in pairs as a form of organizing educational and research activities; using a complex of stimulating methods for evaluating the study results). Perspective paths for study of the students’ academic motivation are indicated.
An International Multi-Stakeholder Delphi Survey Study on the Design of Disease Modifying Parkinson’s Disease Trials
Authors: Zeissler Marie-Louise , McFarthing Kevin , Raphael Karen G. , Rafaloff Gary , Windle Richard , Carroll Camille B. 
Published: November 2023

Background: Design of disease modification (DM) trials for Parkinson’s disease (PD) is challenging. Successful delivery requires a shared understanding of priorities and practicalities. Objective: To seek stakeholder consensus on phase 3 trials’ overall goals and structure, inclusion criteria, outcome measures, and trial delivery and understand where perspectives differ. Methods: An international expert panel comprising people with Parkinson’s (PwP), care partners (CP), clinical scientists, representatives from industry, funders and regulators participated in a survey-based Delphi study. Survey items were informed by a scoping review of DM trials and PwP input. Respondents scored item agreement over 3 rounds. Scores and reasoning were summarized by participant group each round until consensus, defined as≥70% of at least 3 participant groups falling within the same 3-point region of a 9-point Likert scale. Results: 92/121 individuals from 13 countries (46/69 PwP, 13/18 CP, 20/20 clinical scientists, representatives from 8/8 companies, 4/5 funders, and 1/1 regulator) completed the study. Consensus was reached on 14/31 survey items: 5/8 overall goals and structure, 1/8 Eligibility criteria, 7/13 outcome measures, and 1/2 trial delivery items. Extent of stakeholder endorsement for 428 reasons for scores was collated across items. Conclusions: This is the first systematic multi-stakeholder consultation generating a unique repository of perspectives on pivotal aspects of DM trial design including those of PwP and CP. The panel endorsed outcomes that holistically measure PD and the importance of inclusive trials with hybrid delivery models. Areas of disagreement will inform mitigating strategies of researchers to ensure successful delivery of future trials.
PENDAMPINGAN PENYULUH LAPANGAN KELUARGA BERENCANA (PLKB) DALAM VERIFIKASI DAN PELACAKAN FAKTOR DETERMINAN STUNTING-WASTING DI DESA BENGLE
Authors: Simatupang Abdul Malik , Hariyanti Lusiana Pradana , Yanti Wandecha Rahma , Wiboworini Budiyanti 
Published: November 2023

Desa Bengle terletak di Kecamatan Wonosamodro merupakan salah satu desa lokus stunting dengan prevalensi stunting berdasarkan E-PPGBM Maret 2023 sebesar 9,23% dan data pendataan keluarga (PK-21) dengan presentasi keluarga berisiko stunting sebesar 6,7%. Adanya selisih antara data balita stunted dan keluarga berisiko stunting memerlukan solusi yang dapat dilakukan melalui pendampingan PLKB. Tujuan dari pengabdian masyarakat ini yaitu mendampingi PLKB dalam verifikasi dan pelacakan faktor determinan stunting-wasting. Metode yang digunakan yaitu wawancara langsung kepada ibu balita stunting-wasting dengan tahapan prosedur yaitu tahap persiapan dan tahap pelaksanaan. Dalam tahap persiapan dilakukan proses pengumpulan data, memastikan data serta melakukan verifikasi data dari sumber data yang digunakan, selanjutnya pada tahap pelaksanaan balita yang terdeteksi stunting-wasting kemudian dilakukan audit dan pelacakan terhadap faktor determinan stunting-wasting agar dapat dilakukan tindak lanjut yang lebih tepat sesuai akar masalah. Dari kegiatan pendampingan ini didapatkan hasil 2 balita terdiagnosis stunting-wasting dengan faktor determinan dominan yaitu panjang badan lahir, MP-ASI, tinggi badan ibu, pendapatan orang tua dan asupan makan. Kesimpulan yang diperoleh dari hasil kegiatan pengabdian masyarakat ini adalah balita yang teridentifikasi stunted berdasarkan indikator TB/U <-2 SD belum dapat dikatakan stunting. Kegiatan ini telah berhasil menetapkan diagnosis stunting-wasting pada 2 balita dan didapatkan hasil faktor determinan yang dominan antara lain panjang badan saat lahir, MP-ASI, tinggi badan ibu, pendapatan orang tua dan asupan makan balita. Saran yang dapat dilakukan setelah kegiatan pengabdian masyarakat ini yaitu kepada pihak PLKB melalui BKKBN dan Dinas Kesehatan secara bersama melakukan verifikasi dan sinkronisasi data balita stunted agar mendapatkan data balita stunting yang valid.
Prevalence and Impact of BRAF mutation in patients with concomitant papillary thyroid carcinoma and Hashimoto’s thyroiditis: a systematic review with meta-analysis
Authors: Janicki Lukasz , Patel Agastya , Jendrzejewski Jarosław , Hellmann Andrzej 
Published: November 2023

BackgroundEvidence suggests that patients with Hashimoto thyroiditis (HT) are at significantly higher risk of developing papillary thyroid cancer (PTC). However, the course of PTC in patients with both diseases concomitantly has been found to be more indolent than conventional PTC. Additionally, it has been well proven that BRAF mutation results in an aggressive course of PTC. The aims of this meta-analysis were to identify prevalence of BRAF mutation and its impact on clinicopathological features in patients with concomitant PTC-HT. MethodsMedline, Cochrane Library, Scopus, and Web of Science were searched until 16.09.2022, resulting in 227 articles, of which nine studies were included. Summary estimates, comparing patients with (A) BRAF (+) PTC-HT versus BRAF (+) PTC, and (B) BRAF (+) PTC-HT versus BRAF (-) PTC-HT, were generated with Review Manager 5.0. ResultsIn total, 6395 patients were included in this review. PTC-HT patients had significantly less BRAF mutation than PTC patients (Odds Ratio (OR) (95% Confidence Interval (CI))=0.45 (0.35-0.58), P&lt;0.001). BRAF (+) PTC-HT patients were significantly more likely to have multifocal lesions (OR (95% CI)=1.22 (1.04-1.44), P=0.01) but less likely to have lymph node metastasis (OR (95% CI)=0.65 (0.46-0.91), P=0.01) and extrathyroidal extension (OR (95% CI)=0.55 (0.32-0.96), P=0.03) compared to BRAF (+) PTC patients. BRAF (+) PTC-HT patients were more likely to have multifocal lesions (OR (95% CI)=0.71 (0.53-0.95), P=0.02), lymph node metastasis (OR (95% CI)=0.59 (0.44-0.78), P&lt;0.001) and extrathyroidal extension (OR (95% CI)=0.72 (0.56-0.92), P=0.01) compared to BRAF (-) PTC-HT patients. ConclusionThis meta-analysis highlights that the lower prevalence of BRAF mutation in patients with PTC-HT than conventional PTC may explain the indolent clinicopathological course in this cohort.
Risk factors of local control in adrenal metastases treated by stereotactic body radiation therapy - a systematic review and meta-analysis
Authors: Liao Xuehong , Kishi Kazushi , Du Kaixin , Komaki Ritsuko , Mizoe Junetsu , Aikawa Gosuke , Zheng Wei , Pan Chao 
Published: November 2023

PurposeThis study is aimed to explore risk factors affect the therapy outcomes of adrenal metastases (AM) for stereotactic body radiation therapy (SBRT) and guide clinical dose selection.Methods and materialsPubMed, Embase and Web of Science were searched in September 22, 2022 in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Subgroup analysis and meta-regression were used to search for sources of heterogeneity and identify risky outcomes factors. Publication bias test and sensitivity analysis were also conducted.ResultsThirty-three studies with full text from 2009 to 2022 about AM with SBRT on 1483 patients were included. Pooled 1- and 2-year local control (LC) and overall survival(OS) were 81.7% (95% confidence interval [CI], 75.6%-86.5%), 62.8% (95% CI, 53.8%-71.8%), 67.4% (95%CI, 61.8%-73.1%) and 46.5% (95%CI, 40.4%-52.6%), respectively. Biological effective dose (BED, α/β=10Gy) and dose per fraction affected 1-year LC (Qm=23.89, 15.10; P&lt;0.0001, 0.0001). In the range of 60-80Gy (BED10), the group of dose per fraction ≥ 9Gy achieved the excellent 1-year LC (&lt; 9Gy: ≥ 9Gy =78%, 91%; χ2 = 10.16, P = 0.001). Tracking technology significantly affected 1- and 2-year OS (Qm = 5.73, 8.75; P = 0.017, 0.003) and high tracking adoption group showed excellent 1- and 2- year OS (78.7% [95%CI, 68.6%- 88.9%]; and 62.9% [95%CI, 53.1%-72.7%]).ConclusionIncreasing the dose per fraction appropriately may help control locally AM lesious. Tracking technology might contribute to improve survival of advanced patients with AM. But these results need prospective studies to verify them.
Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma
Authors: Raters Verena Maria , Gebauer Florian , Löser Heike , Schröder Wolfgang , Schlösser Hans Anton , Fuchs Hans , Bruns Christiane , Quaas Alexander , Zander Thomas 
Published: November 2023

BackgroundStaging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated combined molecular markers to predict prognosis.Patients and methods890 tumor tissue samples were obtained from patients who underwent surgery for esophageal adenocarcinoma with curative intent. These were stained by tissue micro array for 48 markers which are associated with tumorigenesis and correlated with clinical data (TNM-staging, overall survival) by multivariate Cox regression.ResultsTwo markers (preserved Y chromosome and high grade of (CD3+) T-cell infiltration) were found to be significantly and independently associated with better overall survival. We formed a score (called CY score) from the two markers. The more markers are positive and thus the higher the score (ranging from 0 to 2), the better the overall survival, independently of UICC. Moreover, we developed a combination score of the UICC and CY score based on cluster analysis. Patients with a UICC stage of III with the presence of both traits (CY=2) can be assigned to a better prognosis group (group II), whereas patients with a UICC stage of I without both traits (CY=0) must be assigned to a worse prognosis group (group II). Therefore, patients in stage I with adverse molecular signature might benefit of multimodal therapy.ConclusionIn summary, the CY score adds prognostic information to the UICC stage based on tumor biology in esophageal adenocarcinoma and warrants further evaluations in independent clinical cohorts.
Using digital assessment technology to detect neuropsychological problems in primary care settings
Authors: Libon David J. , Matusz Emily Frances , Cosentino Stephanie , Price Catherine C. , Swenson Rod , Vermeulen Meagan , Ginsberg Terrie Beth , Okoli-Umeweni Adaora Obiageli , Powell Leonard , Nagele Robert , Tobyne Sean , Gomes-Osman Joyce Rios , Pascual-Leone Alvaro 
Published: November 2023

IntroductionScreening for neurocognitive impairment and psychological distress in ambulatory primary and specialty care medical settings is an increasing necessity. The Core Cognitive Evaluation™ (CCE) is administered/scored using an iPad, requires approximately 8 min, assesses 3- word free recall and clock drawing to command and copy, asks questions about lifestyle and health, and queries for psychological distress. This information is linked with patients’ self- reported concerns about memory and their cardiovascular risks.MethodsA total of 199 ambulatory patients were screened with the CCE as part of their routine medical care. The CCE provides several summary indices, and scores on 44 individual digital clock variables across command and copy tests conditions.ResultsSubjective memory concerns were endorsed by 41% of participants. Approximately 31% of participants reported psychological distress involving loneliness, anxiety, or depression. Patients with self-reported memory concerns scored lower on a combined delay 3- word/ clock drawing index (p &lt; 0.016), the total summary clock drawing command/ copy score (p &lt; 0.050), and clock drawing to command Drawing Efficiency (p &lt; 0.036) and Simple and Complex Motor (p &lt; 0.029) indices. Patients treated for diabetes and atherosclerotic cardiovascular disease (ASCVD) scored lower on selected CCE outcome measures (p &lt; 0.035). Factor analyses suggest that approximately 10 underlying variables can explain digital clock drawing performance.DiscussionThe CCE is a powerful neurocognitive assessment tool that is sensitive to patient’s subjective concerns about possible decline in memory, mood symptoms, possible cognitive impairment, and cardiovascular risk. iPad administration ensures total reliability for test administration and scoring. The CCE is easily deployable in outpatient ambulatory primary care settings.
Internalization of negative societal views on old age into self-perceptions of aging: exploring factors associated with self-directed ageism
Authors: Ishikawa Motoko 
Published: November 2023

IntroductionA growing number of research has provided evidence for the negative impact of ageism on older people’s health and well-being. Among the three different manifestations of ageism, namely institutional, interpersonal and self-directed ageism, significant ageism-health associations have been proved to be strongest for self-directed ageism. This supports stereotype embodiment theory, which maintains that lifetime exposure to negative age stereotypes leads to the internalization of ageism as a form of negative attitudes towards own aging and it adversely affects health and well-being in old age. However, little is known about how people internalize negative age stereotypes held in the society into self-perceptions of aging.MethodsThis study aimed to explore how socially shared beliefs about old age are internalized into self-perceptions of aging focusing on uncovering factors related to self-directed ageism. Data were derived from the survey that had examined citizen’s attitudes towards old age and aging in Finland. Multinominal logistic regression models were performed to examine the association of sociodemographic and contextual factors with different combinations of societal age stereotypes and two indicators of self-perceptions of aging: subjective views on old age and personal feelings of own old age.ResultsThe analyses showed that being female, attaining tertiary education, evaluating poor quality of life and awareness of institutional old age discrimination were related to holding negative views on aging towards both society and oneself.DiscussionThe findings from univariate and multivariate models suggest that it is not age per se, but structural and cultural circumstances shaped with growing older that turns socially shared negative age stereotypes into negative self-perceptions of aging. Even though the study addressed situations in one country, the findings have an important implication for other rapidly aging societies regarding how social and cultural contexts are closely linked to the formation of self-directed ageism.
Comparing Effects of Tolvaptan and Instruction to Increase Water Consumption in ADPKD: Post Hoc Analysis of TEMPO 3:4
Authors: Gobburu Joga , Ivaturi Vijay , Wang Xiaofeng , Shoaf Susan E. , Jadhav Pravin , Perrone Ronald D. 
Published: November 2023

Key Points

In a post hoc analysis, short-term reduction in spot urine osmolality (Uosm) was associated with decreased kidney volume growth in autosomal dominant polycystic kidney disease for both tolvaptan and instruction to increase hydration alone.For the same spot Uosm reduction, however, the kidney volume benefit was greater with tolvaptan, possibly because of greater cumulative 24-hour Uosm suppression by tolvaptan.

Background
In addition to decreasing water excretion and increasing urinary concentration, the antidiuretic hormone vasopressin plays a role in the pathophysiology of autosomal dominant polycystic kidney disease. It has been hypothesized that by suppressing vasopressin release, drinking large amounts of water might exert therapeutic effects in autosomal dominant polycystic kidney disease similar to those of tolvaptan, an antagonist of the vasopressin type 2 receptor, but evidence is lacking. We analyzed data from tolvaptan clinical trials to evaluate relationships among water intake, urine osmolality (Uosm), and change in total kidney volume (TKV).

Methods
Analysis of the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes 3:4 clinical trial in which participants were randomized to tolvaptan or placebo and instructed to drink large amounts of water. The relationship between change in spot Uosm from baseline to week 3 and change in TKV to month 12 was assessed using linear regression modeling. Two short-term tolvaptan trials were analyzed to explore relationships between intermittent Uosm sampling and 24-hour Uosm suppression.

Results
With both tolvaptan and placebo (i.e., mandated high water intake alone), Uosm reduction at week 3 was associated with reduction in TKV growth at month 12. However, for the same decrease in spot Uosm, the corresponding reduction in TKV growth was greater for tolvaptan (e.g., a −250 mOsm/kg reduction in Uosm at week 3 was associated with a −1% change in TKV at month 12 for tolvaptan versus +4.5% for placebo). In short-term trials, similar reductions in spot or trough Uosm values were achievable with tolvaptan and high water intake, but cumulative 24-hour suppression was greater with tolvaptan.

Conclusions
This analysis supports a relationship between effects on Uosm and inhibition of disease progression by tolvaptan and high water intake alone. The findings further suggest that 24-hour Uosm measurement is superior to spot Uosm for assessing suppression of vasopressin activity by tolvaptan.
External Validation of a Novel Multimarker GFR Estimating Equation
Authors: Tio Maria Clarissa , Zhu Xiaoqian , Lirette Seth , Rule Andrew D. , Butler Kenneth , Hall Michael E. , Dossabhoy Neville R. , Mosley Thomas , Shafi Tariq 
Published: November 2023

Key Points

Using multiple markers may improve GFR estimation especially in settings where creatinine and cystatin C are known to be limited.Panel eGFR is a novel multimarker eGFR equation consisting of age, sex, cystatin C, and nuclear magnetic resonance–measured creatinine, valine, and myo-inositol.eGFR-Cr and eGFR-Cr-CysC may underestimate measured GFR, while panel eGFR was unbiased among younger Black male individuals.

Background
Using multiple markers may improve accuracy in GFR estimation. We sought to externally validate and compare the performance of a novel multimarker eGFR (panel eGFR) equation among Black and White persons using the Genetic Epidemiology Network of Arteriopathy cohort.

Methods
We included 224 sex, race/ethnicity, and measured GFR (mGFR) category–matched persons, with GFR measured using urinary clearance of iothalamate. We calculated panel eGFR using serum creatinine, valine, myo-inositol, cystatin C, age, and sex. We compared its reliability with current eGFR equations (2021 CKD Epidemiology Collaboration creatinine [eGFR-Cr] and creatinine with cystatin C [eGFR-Cr-CysC]) using median bias, precision, and accuracy metrics. We evaluated each equation's performance in age, sex, and race subgroups.

Results
In the overall cohort, 49% were Black individuals, and mean mGFR was 79 ml/min per 1.73 m2. Panel eGFR overestimated mGFR (bias: −2.4 ml/min per 1.73 m2; 95% confidence interval [CI], −4.4 to −0.7), eGFR-Cr-CysC underestimated mGFR (bias: 4.8 ml/min per 1.73 m2; 95% CI, 2.1 to 6.7), while eGFR-Cr was unbiased (bias: 2.0 ml/min per 1.73 m2; 95% CI, −1.1 to 4.6). All equations had comparable accuracy. Among Black male individuals younger than 65 years, both eGFR-Cr (bias: 17.0 ml/min per 1.73 m2; 95% CI, 8.6 to 23.5) and eGFR-Cr-CysC (bias: 14.5 ml/min per 1.73 m2; 95% CI, 6.0 to 19.7) underestimated mGFR, whereas panel eGFR was unbiased (bias: 1.7 ml/min per 1.73 m2; 95% CI, −3.4 to 10.0). Metrics of accuracy for all eGFRs were acceptable in all subgroups except for panel eGFR in Black female individuals younger than 65 years (P30: 73.3%).

Conclusions
Panel eGFR can be used to estimate mGFR and may have utility among Black male individuals younger than 65 years where current CKD Epidemiology Collaboration equations are biased.
ANALISIS KEPATUHAN PERPAJAKAN BENDAHARAWAN PEMERINTAH DI DINAS PARIWISATA DAERAH PROVINSI SULAWESI UTARA
Authors: Pangkey Maria , Warongan Jessy D. L. , Wangkar Anneke 
Published: November 2023

Pajak mempunyai peranan yang sangat penting dalam kehidupan bernegara, khususnya di dalam pelaksanaan pembangunan. Salah satu upaya dalam meningkatkan kepatuhan Wajib Pajak adalah memberikan pelayanan yang baik kepada Wajib Pajak. Peningkatan kualitas dan kuantitas pelayanan diharapkan dapat meningkatkan kepuasan kepada Wajib Pajak sebagai pelanggan sehingga meningkatkan kepatuhan dalam bidang perpajakan. Penelitian ini bertujuan untuk mengetahui bagaimana kepatuhan perpajakan Bendaharawan Pemerintah di Dinas Pariwisata Daerah Provinsi Sulawesi Utara. Penelitian ini menggunakan pendekatan kualitatif dengan metode analisis deskriptif. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu wawancara dan dokumentasi. Analisis data yang dilakukan dalam penelitian ini yaitu dengan mengumpulkan data, mereduksi data, menyajikan data kemudian menarik kesimpulan. Hasil penelitian ini menunjukkan bahwa Bendaharawan Pemerintah pada Dinas Pariwisata telah patuh dalam menjalankan kewajibannya sebagai wajib pajak pihak ketiga dalam menyetorkan pajak terutang, melaporkan pajak, menghitung pajak terutang dan memotong maupun memungut pajak.

Kata Kunci: kepatuhan perpajakan