bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the effect of land use patterns on cooling energy demand for residential buildings in Montreal: A Weather Research and Forecasting (WRF) model approach
Authors: ERREBAI Farid BOUDALI , STREBEL Dominik , CARMELIET Jan , DEROME Dominique 
Published: February 2024

Abstract

The relationship between Urban Heat Island (UHI) phenomenon and cooling energy use in buildings has been widely observed and studied. In this paper, the effect of land use (river, urbanization, and vegetation) is investigated to examine how vegetation and river can dampen the effect of the UHI in various locations and its influence on the cooling energy demand of Montreal residential buildings. The climatic data for the period of interest from May 15th to June 29th, 2020 covering two heatwave periods are simulated by Weather Research and Forecasting (WRF) modeling, and validated by data against weather observing stations (WOS). The results show that the average reduction in the cooling energy demand (CED) of the urbanization scenario compared to the river scenario is: 7% for the suburban location, 10.8% for locations facing the river, 1.2% for the rural location, and ranges from 3.4–7.6% for the urban locations, whereas compared to the vegetation scenario, the reduction in the CED is less compared to the river scenario except for locations facing the river. The daily average of CED during the heatwave period is almost twice as high compared to that of the remaining summer period. This study provides insights in the potential of cooling mitigation solutions.
Activity-Induced Annealing leads to Ductile-to-Brittle Transition in Amorphous Solids
Authors: Karmakar Samarajit , Sharma Rishabh 
Published: February 2024

Abstract

Active glasses are dense and disordered systems consisting of motile particles, capturing the phenomenology observed in many biological systems. We investigate motility-driven annealing and fluidization in these systems, offering new perspectives on cellular ageing and maturation. Our study establishes a correspondence between the yielding behavior of glassy systems under active dynamics and their yielding under oscillatory shear, revealing strikingly similar phase diagrams with areas of annealing and fluidization. The yielded region of the phase diagram may correlate with tissue fluidization, while the annealing region may explain age-related maturation and stiffening. This suggests that some mechanical changes observed in ageing tissues may partially stem from processes analogous to enhanced ageing observed in active glasses. Furthermore, by studying the mechanical response to tension in such systems, we establish that the degree of annealing alone cannot elicit a brittle response; the sample's geometry, particularly its ability to accommodate a shear band, is crucial. Thus, one must consider the embedding geometry for a complete picture of yielding and mechanical response in biological matter. Additionally, we explore the interplay between imposed and internal time scales in active glasses, shedding light on their complex mechanical responses.
Fourier perspectives on Gegenbauer polynomial smoothing
Authors: Wang Yue , Healy John 
Published: February 2024

Abstract
Gibbs ringing is an artifact that occurs physically in many signal and image acquisition modalities. Gegenbauer reconstruction is an approach to reducing Gibbs artifacts based on polynomial smoothing of continuous regions of the signal using Gegenbauer polynomials. In this work, we systematically explain Gegenbauer reconstruction in the signal processing context. We investigate how the parameters, lambda and m, impact the behavior of Gegenbauer reconstruction. We make a quantitative comparison between Gegenbauer reconstruction and other Gibbs suppression methods. Gegenbauer reconstruction assumes that the locations of the discontinuities are known, so we examined how faulty edge detection results could impact Gegenbauer reconstruction. Our results question the standing of Gegenbauer reconstruction in the literature as an exceptionally high performing method of Gibbs ringing reduction.
First-in-human comparison of second- versus third-generation L1CAM-specific CAR T cells in patients with primary refractory or relapsed neuroblastoma
Authors: Pinto Navin , Künkele Annette , Albert Catherine , Taylor Mallory , Ullom Heidi , Wilson Ashley , Huang Wenjun , Wendler Jason , Seidel Kristy , Brown Christopher , Gustafson Joshua , Rawlings-Rhea Stephanie , Beebe Adam , Mgebroff Stephanie , Gardner Rebecca , Jensen Michael , Park Julie 
Published: February 2024

Abstract
Outcomes for children with relapsed and refractory neuroblastoma are dismal. ENCIT-01 is our first-in-human experience in patients with relapsed and refractory neuroblastoma using chimeric antigen receptor (CAR) T cells targeting L1-CAM, an adhesion molecule that is overexpressed in neuroblastoma with limited normal tissue expression. This trial evaluated three different CAR constructs: a short spacer second-generation 4-1BB CAR (Arm A), a short spacer third-generation 4-1BB+CD28 CAR (Arm B) and a long spacer second-generation 4-1BB CAR (Arm C). Thirty-six patients were enrolled and 22 were treated (Arm A n=11, Arm B n=8 and Arm C n=3). Cytokine-release syndrome, skin rash and dose-limiting hyponatremia were recurrently encountered toxicities. Patterns of toxicity appeared at lower dose levels on Arm B and Arm C compared to Arm A, suggesting enhanced potency of the third generation and long spacer products. No objective responses were seen. Correlative analyses demonstrated CAR T cells infiltration into tumor and skin, with evidence of macrophage tumor infiltration. In addition, enhanced CD107a production in the third-generation products when compared to patient matched second generation product, potentially explaining the observation of toxicities at lower dose levels. While feasible to manufacture in a heavily pretreated population, additional engineering safety of L1CAM CAR T cells and/or strategies to target the immunosuppressive tumor microenvironment may be needed to prevent toxicity and provide durable anti-tumor effects.
Characteristics That Affect the Long-term Clinical Outcome and Stroke Recurrence in Ischaemic Stroke Patients With Basilar Artery Atherosclerosis
Authors: dinç yasemin , ozpar rifat , MESUT Gizem , hojjati farid , gokce serhat , sigirli deniz , oguz-akarsu emel , saridas furkan , bakar mustafa , hakyemez bahattin 
Published: February 2024

Abstract
İntroduction: Posterior circulation stroke differs from anterior circulation stroke in etiopathogenesis. Studies have shown that the most common stroke aetiology in posterior circulation stroke is ischemic stroke due to large vessel atherosclerosis. However, even under aggressive medical treatment, the risk of recurrent ischemic stroke in ischemic stroke due to intracranial atherosclerotic stenosis remains high. This study aims to obtain the rate of atherosclerotic disease of the BA in our ischemic stroke population, to determine its symptomatology, and to determine the factors affecting clinical outcome and ischaemic stroke recurrence in the symptomatic group. Material method: we included 107 patients who were diagnosed with acute ischemic stroke with basilar artery stenosis. Results According to the results of our study, the degree of stenosis in atherosclerotic stenosis of the symptomatic BA was found to be an independent risk factor for stroke recurrence. Independent risk factors for unfavourable clinical outcomes in these patients were determined as female gender, stenosis being in the proximal segment, stroke mechanism being from artery to artery embolism, and congestive heart failure. Discussion The most striking result of our study is that clinical outcome was found to be closely related to the female gender, the stroke mechanism being artery-to-artery embolism, and the stenosis is in the proximal segment. If stroke mechanisms were evaluated more clearly, it would likely help provide individualized treatments.
An intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally-deposited yolk lipids
Authors: Sun Yonghua , Chen Zhengfang , He Mudan , Wang Houpang , Li Xuehui , Qin Ruirui , Ye Ding , Zhai Xue , Zhu Junwen , Zhang Quanqing , Hu Peng , Shui Guanghou 
Published: February 2024

Abstract

Although the metabolism of yolk lipids such as docosahexaenoic acid (DHA) is known to play important roles in embryonic development, the underlying mechanism remains unclear. Here we found that the zebrafish hsd17b12a, which encodes an intestinal epithelial-specific enzyme, is crucial for the biosynthesis of long-chain fatty acids (LCFAs) in primitive intestine of larval fish. The deficiency of hsd17b12a leads to severe developmental defects in the primitive intestine and exocrine pancreas. Mechanically, hsd17b12a deficiency interrupts DHA synthesis from essential fatty acids (EFAs) derived from yolk-deposited triglycerides (TAGs), and consequently disrupts an intestinal DHA-phosphatidic acid (PA)-phosphatidylglycerol (PG) axis. This ultimately results in developmental defects of digestive organs, primarily driven by ferroptosis. Our findings indicate that the DHA-PA-PG axis in the primitive intestine facilitates the uptake of yolk lipids and promotes the expansion of digestive organs, thereby uncovering a novel mechanism through which DHA regulates embryonic development.
Evolutionarily conserved fMRI network dynamics in the mouse, macaque and human brain
Authors: Gozzi Alessandro , Gutierrez-Barragan daniel , Ramirez Julian , Panzeri Stefano , Xu Ting 
Published: February 2024

Abstract

Evolutionarily relevant networks have been previously described in several mammalian species using time-averaged analyses of fMRI time-series. However, fMRI network activity is highly dynamic and continually evolves over timescales of seconds. Whether the dynamic organization of resting-state fMRI network activity is conserved across mammalian species remains unclear. Using frame-wise clustering of fMRI time-series, we find that intrinsic fMRI network dynamics in awake macaques and humans is characterized by recurrent transitions between a set of 4 dominant, neuroanatomically homologous fMRI coactivation modes (C-modes), three of which are also plausibly represented in the rodent brain. Importantly, in all species C-modes exhibit species-invariant dynamic features, including preferred occurrence at specific phases of fMRI global signal fluctuations, and a state transition structure compatible with infraslow coupled oscillator dynamics. Moreover, dominant C-mode occurrence reconstitutes the static organization of the fMRI connectome in all species, and is predictive of ranking of corresponding fMRI connectivity gradients. These results reveal a set of species-invariant principles underlying the dynamic organization of fMRI networks in mammalian species, and offer novel opportunities to relate fMRI network findings across the phylogenetic tree.
Epidemiological, multidisciplinary analysis using molecular, morphological, and immunological approaches in the Diplostomasis infections in Oreochromis niloticus
Authors: Mahdy Olfat A. , Attia Marwa A. , Salem Mai A. , Mahdy Olfat A. 
Published: February 2024

Abstract
We aim to describe the epidemiological, multidisciplinary analysis using molecular, morphological, and immunological approaches in the Diplostomasis infections on Oreochromis niloticus in different localities in Egypt. This was a descriptive retrospective study that collected 470 Nile tilapia samples from 4 governorates, in Egypt during the period from January 2022 and December 2023. The variables studied were epidemiological, molecular, morphological, and immunological approaches. For the isolates D. ardeaeand D. spathaecum, entirely sequences of the ITS2 region genes and partial sequences of the cytochrome C oxidase subunit 1 (Cox1) "barcode" area was amplified. Cox1 partial sequences were utilized to analyze the haplotype diversity and potential host-associated structures of the most prevalent parasite species, as well as for the genetic determination of isolates. New primers were designed for the amplification of the investigated genes. Therefore, this study aimed to detect various pro-inflammatory cytokines in fish infected with Diplostomum MCs using an immunological approach. (IFN-γ, IL-2, IL-6, TNF-α, & TNF-β) in the infected muscles contain Diplostomum sp. using quantitative real-time PCR (qRT-PCR). In addition, histopathological alterations of EMCs induced Zenkers necrosis and mononuclear inflammatory cells of fish muscle bundles response with muscular inflammation of infected fishes. In Egypt, an epidemiological study of two Diplostomid trematodes either metacercarial (D. spathaceum) in the eye and encysted metacercarial (D.ardeae) infections in the muscles of O. niloticus fish from four geographically different areas. The first genetic characterizations and immunological approach of two Diplostomum spp.; D. spathaceum and D.ardeae were all deposited in GenBank under the accession numbers (OR763842.1) and (OR755782.1).
Development and psychometric properties of a perceived social support scale for nurses returning to work after childbirth
Authors: Li Suya , Fan Junyao , Liu Yu , Yu Mingfeng , Jiang Yaqian 
Published: February 2024

Abstract

Background:There has been an increase in the number of nurses returning to work after childbirth (NRWCs) in Chinese hospital. Social support is important for NRWCs.
Objective: To develop and validate a perceived social support scale for NRWCs in China.
Method: The original items were based on a literature review, the social support theory, and semi-structured interviews. The Delphi technique was used to adjust further and screen the scale entries to form an initial draft of the scale. From February to October 2023, we recruited 627 NRWCs from hospitals in 12 provinces of China. The psychometric attributes of the scale were examined by construct validity, content validity, test–retest reliability, and internal consistency reliability. The STROBE checklist was used to guide the submission.
Results: 4 dimensions and 22 items compose the initial scale. Exploratory factor analysis verified a four-factor scale structure. The confirmatory factor analysis results showed that the four-factor structure model fitted well. The resulting scale contains 4 dimensions with 18 items. The item-level content validity index ranged from 0.83 to 1.00. The Cronbach's alpha coefficient of four dimensionsand total scale were respectively 0.957, 0.899, 0.870, 0.945, 0.967. The reliability of the scale over time was further verified, with a coefficient of 0.809 for the overall scale and a range from 0.682 to 0.718for each domain.
Conclusion: Theperceived social support scale for NRWCs is a reliable and valid instrument. The application of the Perceived Social Support Scale for NRWCs would improve the assessment of social support among NRWCs.
Phase-precession-like Effects in the Anterior Insula Cortex during Reward Expectancy
Authors: Yang Linglin , Lehongre Katia , Ye Hongyi , Yu XinFeng , Navarro Vincent , Cheng Sen , Lin Zheng , Axmacher Nikolai , Wang Shuang , Zhang Hui 
Published: February 2024

Abstract
Reward expectancy shapes behavioral performance by coordinating the allocation of cognitive resources, which incorporates the involvement of the anterior insular cortex (AIC). To investigate AIC’s electrophysiological mechanisms during reward expectancy, we collected intracranial electroencephalographic data from epilepsy patients implanted for clinical purposes. During recording, they navigated a virtual T-maze where they encountered rewards at three predetermined locations. We focused on the time window proximal to entering the reward zone, defined as the expectancy stage. During this stage, a robust phase-amplitude coupling (PAC) between theta oscillation and gamma activity was found within the AIC. This PAC exhibited a specific temporal structure, with peak gamma activity progressively coupling to an earlier theta phase before each reward onset. These phase shift phenomena mirrored the phase precession effect, termed phase-precession-like effects (PPLEs). Meanwhile, the reward-specific neural patterns were pre-activated during the expectancy stage of rewards, coinciding with peak gamma activities across trials. Additionally, subjects exhibiting PPLEs in the AIC presented reduced variability and a more pronounced enhancement in response latency across trials. These results revealed potential electrophysiological mechanisms of the AIC underlying reward expectancy.
Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology
Authors: Kawaoka Yoshihiro , Ueki Hiroshi , Wang I-Hsuan , Kiso Maki , Horie Kenta , Iida Shun , Mine Sohtaro , Ujie Michiko , Hsu Hung-Wei , Henry Chen-Hui , Imai Masaki , Suzuki Tadaki , Kamitani Wataru , Kawakami Eiryo 
Published: February 2024

Abstract

Microthrombus formation is associated with COVID-19 severity; however, the detailed mechanism remains unclear. In this study, we investigated mouse models with severe pneumonia caused by SARS-CoV-2 infection by using our in vivo two-photon imaging system. In the lungs of SARS-CoV-2-infected mice, increased expression of adhesion molecules in intravascular neutrophils prolonged adhesion time to the vessel wall, resulting in platelet aggregation and impaired lung perfusion. Re-analysis of scRNA-seq data from peripheral blood mononuclear cells from COVID-19 cases revealed increased expression levels of CD44 and SELL in neutrophils in severe COVID-19 cases compared to a healthy group, consistent with our observations in the mouse model. These findings suggest that pulmonary perfusion defects caused by neutrophil adhesion to pulmonary vessels contribute to COVID-19 severity.
Rosiglitazone promotes oligodendrocyte development and myelin formation of repeated neonatal sevoflurane exposure via PPARγ signaling
Authors: Cao Tianyu , Jiang Sufang , Wang Xueji , Huang Peiying , Zhou Lijie , Di Lichao , Han Shuang , Huang Lining 
Published: February 2024

Abstract

One of the most prevalent general anesthetics for kids and infants is sevoflurane. According to recent research, repeated exposure to sevoflurane in neonates induces cognitive and motor deficits. Peroxisome proliferator-activated receptor-γ (PPARγ) agonists have drawn plenty of attention recently as possible therapies for a variety of neurological conditions. In this research, we evaluated whether pretreatment with rosiglitazone in neonatal mice can repair myelination defects, cognitive impairment, and motor dysfunction via PPARγ. The mice were treated with 3% sevoflurane for two hours on postnatal days 6–8. The behavioral tests were conducted from P29 to P34. Additionally, we evaluated morphological and functional symptoms related to myelin.Our results showed that rosiglitazone pretreatment significantly ameliorated the cognitive and motor impairments of repeated neonatal sevoflurane exposure. Meanwhile, rosiglitazone pretreatment promoted oligodendrocyte precursor cell (OPCs) differentiation and myelination.This suggests that rosiglitazone may be used in clinical settings to increase the security of neonatal sevoflurane exposure. Furthermore, PPARγ and FASN may be mediators of rosiglitazone, which alleviates myelination defects, cognitive impairment, and motor dysfunction.
Efficient plant regeneration through callus culture in Hedychium spicatum Buch.Ham. ex. D. Don using response surface methodology
Authors: Dhyani Vibhash , Bhatt Indra D , Pandey Veena 
Published: February 2024

Abstract

Hedychium spicatum(Family-Zingiberaceae), commonly known as Kapoor Kachri is widely known for its medicinal properties and high market demand. The species is harvested mainly from the wild to meet the raw material requirements for the pharmaceutical and cosmaceutical industries; therefore, it needs urgent attention for its conservation and mass production. The present study developed an efficient in vitro propagation protocol for large-scale species production. The central composite design- response surface methodology (CCD-RSM) experiment was designed to optimize the plant growth regulators (PGRs) concentration for maximum callus production, shoot regeneration and rooting. Seed radicle was used as explants in Murashige and Skoog (MS) medium supplemented with different concentrations of naphthalene acetic acid (NAA; 2.5-5.0 µM) in combination with thidiazuron (TDZ; 2.5-5.0 µM) for callus induction. TDZ (5µM) with NAA (2.5µM) showed maximum callus induction (98%) after 6 weeks of incubation. Callus pieces were transferred to MS medium supplemented with different concentrations of TDZ, NAA and Indole-3-butyric acid (IBA) for shoot regeneration. The highest regeneration frequency (100 %) was observed on MS medium enriched with 2.5 µM TDZ and 3.5 µM NAA that showed a maximum number of shoots/explants (16.19 no.). Regenerated shoots were rooted better (average number of roots/shoot - 11.71) on MS medium supplemented with 2 µM NAA and 1.5 µM IBA in combination. After subsequent acclimatization and hardening process in the greenhouse, the plantlets were planted in the experimental field with a survival rate of 83% after 4 months. The protocol established in the present study has prospects to meet the challenges of quality planting material for large-scale cultivation and raw material sources for industrial utilization.
The Evaluation of risk factors and prognostic impact of glucocorticoid therapy among non-HIV patients with Pneumocystis Jirovecii Pneumonia (PCP) Running title：Glucocorticoid therapy among non-HIV patients with PCP
Authors: Li Jun , Mu Xiangdong , Li Haichao , Liu Xinmin 
Published: February 2024

Abstract

Background
Glucocorticoids have been shown to be very effective in the treatment of Human Immunodeficiency Virus (HIV) associated Pneumocystis jirovecii Pneumonia (PCP). However, risk factors and the impact on prognosis in non-HIV-PCP patients remain unclear. Our study aimed to early identification risk factors and prognostic impact of glucocorticoids therapy in non-HIV-PCP patients to decrease patients’ mortality.
Methods
A retrospective study was conducted on adult (≥ 18 years old) patients diagnosed with non-HIV-PCP in Peking University First Hospital from April 2007 to October 2022. A total of 269 patients with non-HIV-PCP were hospitalized during the period, and 200 patients were eventually included. Demographic data and related clinical data were collected. Univariate and multivariate logistic regression were used to analyze the relationship between variables and poor prognosis.
Results
A total of 200 non-HIV-PCP patients were included. 29% (58/200) patients died during admission. Univariate analysis showed that age, history of chemotherapy, history of glucocorticoid, autoimmune disease, organ transplantation, respiratory failure, platelet count, neutrophil/lymphocyte ratio, highly sensitive C-reactive protein, albumin, lactic dehydrogenase, d-dimer, bronchoalveolar lavage fluid (BALF)-neutrophil percentage, BALF-lymphocyte percentage, hospital-acquired pneumonia associated pathogen infection, pneumothorax, mediastinal emphysema, caspofungin therapy and high dose (≥ 1mg/(kg· d)) glucocorticoids therapy have a risk of death due to PCP patients. Multivariate analysis showed that age (OR = 1.062, 95%CI 1.021–1.104, P = 0.003), hospital-acquired pneumonia associated pathogen infection (OR = 4.170, 95%CI 1.407–12.357, P = 0.010) and high dose glucocorticoid therapy (OR = 7.047, 95%CI 2.482–20.006, P < 0.001) were independent risk factors for in-hospital death in non-HIV-PCP patients.
Conclusions
Considering the rapid course of the disease in non-HIV-infected immunocompromised patients. Early identification of high-risk PCP patients is critical to reduce morbidity and mortality. Our study found that non-HIV-PCP patients treated with high doses of glucocorticoids, old age, history of chemotherapy and hospital-acquired pneumonia associated pathogen infection had worse outcomes during hospitalization.