bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Lung Cancer Cases in Chest CT Scans Utilizing Artificial Intelligence: A Retrospective Analysis of Data During the COVID-19 Pandemic
Authors: Zukov R.A , Safontsev I.P. , Klimenok M.P , Zabrodskaya T.E. , Merkulova N.A. , Chernina V.Yu , Belyaev M.G. , Goncharov M.Yu , Omelyanovsky V.V. , Ulyanova K.A. , Soboleva E.A. , Donskova M.A , Blokhina M.E. , Nalivkina E.A , Gombolevskiy V.A 
Published: December 2023

AbstractPurposeTo evaluate the potential of using artificial intelligence (AI) focused pulmonary nodule search on chest CT data obtained during the COVID-19 pandemic to identify lung cancer (LC) patients.MethodsA multicenter, retrospective study in the Krasnoyarsk region, Russia analyzed CTs of COVID-19 patients using the automated algorithm, Chest-IRA by IRA Labs. Pulmonary nodules larger than 100 mm³ were identified by the AI and assessed by four radiologists, who categorized them into three groups: “high probability of LC”, “insufficiently convincing evidence of LC”, “without evidence of LC”. Patients with findings were analyzed by radiologists, checked with the state cancer registry and electronic medical records. Patients with confirmed findings that were not available in the cancer registry were invited for chest CT and verification was performed according to the decision of the medical consilium. The study also estimated the economic impact of the AI by considering labor costs and savings on treatment for patients in the early stages compared to late stages, taking into account the saved life years and their potential contribution to the gross regional product.ResultsAn AI identified lung nodules in 484 out of 10,500 chest CTs. Of the 484, 355 could be evaluated, the remaining 129 had de-anonymization problems and were excluded. Of the 355, 252 cases having high and intermediate probabilities of LC, 103 were found to be false positives. From 252 was 100 histologically verified LC cases, 35 were in stages I-II and 65 were in stages III-IV. 2 lung cancers were diagnosed for the first time. Using AI instead of CT review by radiologists will save 2.43 million rubles (23,786 EUR/ 26690 USD/ 196,536 CNY) in direct salary, with expected savings to the regional budget of 8.22 million rubles (80,463 EUR/ 90,466 USD/ 666,162 CNY). The financial equivalent of the life years saved was 173.25 million rubles (1,695,892 EUR/ 1905750 USD/ 14,033,250 CNY). The total effect over five years is estimated at 183.9 million rubles (1,800,142 EUR/ 2,022,907 USD/ 14,895,949 CNY).ConclusionUsing AI to evaluate large volumes of chest CTs done for reasons unrelated to lung cancer screening may facilitate early and cost-effective detection of incidental pulmonary nodules that might otherwise be missed.
Genome-wide analysis of brain age identifies 25 associated loci and unveils relationships with mental and physical health
Authors: Jawinski Philippe , Forstbach Helena , Kirsten Holger , Beyer Frauke , Villringer Arno , Witte A. Veronica , Scholz Markus , Ripke Stephan , Markett Sebastian 
Published: December 2023

AbstractNeuroimaging and machine learning are opening up new opportunities in studying biological aging mechanisms. In this field, ‘brain age gap’ has emerged as promising MRI-based biomarker quantifying the deviation between an individual’s biological and chronological age of the brain – an indicator of accelerated/decelerated aging. Here, we investigated the genetic architecture of brain age gap and its relationships with over 1,000 health traits. Genome-wide analyses in 32,634 UK Biobank individuals unveiled a 30% SNP-based heritability and highlighted 25 associated loci. Of these, 23 showed sign-consistency and 16 replicated in another 7,259 individuals. The leading locus encompassesMAPT, encoding the tau protein central to Alzheimer’s disease. Genetic correlations revealed relationships with various mental health (depression), physical health (diabetes), and socioeconomic variables (education). Mendelian Randomization indicated a causal role of enhanced blood pressure on accelerated brain aging. This work refines our understanding of genetically modulated brain aging and its implications for human health.
A Scoping Review of Deaf Awareness Programs in Health Professional Education
Authors: Terry Julia , Meara Rhian 
Published: December 2023

AbstractDeaf awareness aims to promote understanding about Deaf and hard of hearing people, with the goal of reducing barriers between Deaf and hearing populations; and is particularly pertinent for health professional students as they need to learn to communicate effectively with a range of population groups. This scoping review aims to provide an overview of literature examining Deaf awareness programs provided to health professional students during their initial training. We searched four medical and public health databases and registers using terms related to Deaf awareness. We used the PRISMA-ScR reporting standards checklist for scoping reviews. We identified 10,198 citations, with 15 studies included in the final review. Searches were performed during August to September 2022, and April 2023. Studies were included provided they examined Deaf awareness content or programs within health professional education. Data were extracted by two independent reviewers who screened all abstracts using Rayyan software, followed by discussion to achieve knowledge synthesis and agreement. In all, a total of 15 articles from six countries were identified across health professional student disciplines including pharmacy, nursing, audiology, inter-professional and medical programs. The review found sparse evidence of research into Deaf awareness programs delivered to health professional students, with delivery often solely to small groups of students, indicating why so few students can access information about how to communicate effectively with Deaf and hard of hearing patients during their initial training programs. This scoping reviewed showed evidence of promising benefits for health professional students undertaking Deaf and hard of hearing awareness programs during their undergraduate education. The importance of communicating with Deaf and hard of hearing patients and attaining Deaf cultural competencies for health professional students should be investigated in future research.
Neuroimaging markers of patient-reported outcome measures in acute ischemic stroke
Authors: Oliveira Lara C. , Bonkhoff Anna K. , Regenhardt Robert W. , Alhadid Kenda , Tuozzo Carissa , Etherton Mark R. , Rost Natalia S. , Schirmer Markus D. 
Published: December 2023

ABSTRACTObjectivesTo determine the relationship between patient-reported outcome measures (PROMs) and volumetric imaging markers in acute ischemic stroke (AIS).Patients and MethodsPatients presenting at Massachusetts General Hospital between February 14, 2017 and February 5, 2020 with a confirmed AIS by MRI were eligible and underwent a telephone interview including PROM-10 questionnaires 3-15 months after stroke. White matter hyperintensity (VWMH) and brain volumes (VBrain) were automatically determined using admission clinical MRI. Stroke lesions were manually segmented and volumes calculated (VLesion). Multivariable and ordinal regression analyses were performed to identify associations between global and PROM-10 subscores with brain volumetrics and clinical variables.ResultsUtilizing data from 167 patients (mean age: 64.7; 41.9% female), higher VWMHwas associated with worse global physical (β=-0.6), global mental (β=-0.65), physical health (OR=0.68), social satisfaction (OR=0.66), fatigue (OR=0.69) and social activities (OR=0.59) scores. Higher VLesionwas associated with poorer global mental (β=-0.79), mental health (OR=0.68), physical (OR=0.66) and social activities (OR=0.55), and emotional distress (OR=0.68) scores. Higher VBrainwas linked to better global mental (β=0.93), global physical (β=0.79), mental health (OR=1.54) and physical activities (OR=1.72) scores.ConclusionsNeuroimaging biomarkers were significantly associated with PROMs, where higher VWMHand VLesionled to worse outcome, while higher VBrainwas protective. The inclusion of neuroimaging analyses and PROMs in routine assessment provides enhanced understanding of post-stroke outcomes.
Projected health and economic effects of nonavalent versus bivalent human papillomavirus vaccination in preadolescence in the Netherlands
Authors: Sollie Birgit , Berkhof Johannes , Bogaards Johannes A. 
Published: December 2023

AbstractBackgroundMost European countries offer human papillomavirus (HPV) vaccination through organized immunisation programmes, but the choice of vaccine varies. We compared the expected health and economic effects of the currently used bivalent vaccine, targeting HPV-16/18, and the nonavalent vaccine, targeting seven additional genotypes, for the Netherlands.MethodsWe estimated the incremental impact of nonavalent versus bivalent vaccination in a cohort of 100,000 girls and 100,000 boys offered vaccination at age 10, by projecting type-specific infection risk reductions onto expected number of cervical screening outcomes, HPV-related cancers, and treatments for anogenital warts and recurrent respiratory papillomatosis (RRP). In the base-case, we assumed two-dose vaccination with 60% uptake, lifelong partial cross-protection against HPV-31/33/45 for the bivalent vaccine and EUR 25 extra costs per dose for the nonavalent vaccine. Cost-effectiveness was assessed by comparing the incremental cost-effectiveness ratio (ICER) per life-year gained (LYG) with the Dutch threshold of EUR 20,000/LYG.FindingsCompared with bivalent vaccination, nonavalent vaccination prevents an additional 1320 high-grade cervical lesions, 70 cancers, 34,000 anogenital warts episodes and 30 RRPs; and generates EUR 4·0 million discounted savings from fewer treatments. The ICER is EUR 6192 (95% credible interval: 4166; 7916)/LYG in the base-case, but exceeds the cost-effectiveness threshold when cross-protection for the bivalent vaccine extends to non-31/33/45 genotypes or when vaccine efficacy wanes past age 20 with either vaccine.InterpretationSex-neutral vaccination with the nonavalent vaccine is likely to be cost-effective. Long-term monitoring of type-specific vaccine effectiveness is essential because of the impact of cross-protection and waning efficacy on cost-effectiveness.
Geometric Quantification of Cell Phenotype Transition Manifolds with Information Geometry
Authors: Huang Miao , Ying Junda , Wang Yuxuan , Zhou Haijun , Zhang Lei , Wang Weikang 
Published: December 2023

AbstractCell phenotype transition (CPT) plays a pivotal role in various biological processes like development. Recent advancements in single-cell sequencing techniques have uncovered that cell transition dynamics during development are confined on low-dimensional manifolds. However, existing methods are inadequate for directly quantifying the manifolds from experimental data. Here we present SCIM (single cell information manifolds), a novel geometry-guided method to quantify the CPT manifolds using information geometry. In particular, we convert single cells’ high-dimensional gene vectors into probability distributions via Gaussian embedding. The Fisher metric is naturally defined in this embedding space. With the transformed Gaussian distributions, we calculate the coarse Ricci curvature of each single cell. Our analyses reveal that the cells with low curvature are associated with critical transitions. To further examine the invariant characteristics of the manifolds of CPT, we compute the information velocity of each single cell based on RNA velocity. Remarkably, the regions with high information velocity correspond with the low curvature regions, indicating that the geometry can guide the dynamics of single cells on the manifolds. The proposed method not only unveils the invariant characteristics of the CPT manifolds, but also establishes a generic approach for quantifying the intricate dynamics on the CPT manifolds.
Molecular identification of wide-field amacrine cells in mouse retina that encode stimulus orientation
Authors: Park Silvia J. , Lei Wanyu , Pisano John , Orpia Andrea , Minehart Jacqueline , Pottackal Joseph , Hanke-Gogokhia Christin , Zapadka Thomas E. , Clarkson-Paredes Cheryl , Popratiloff Anastas , Ross Sarah E. , Singer Joshua H. , Demb Jonathan B. 
Published: December 2023

SUMMARYVisual information processing is sculpted by a diverse group of inhibitory interneurons in the retina called amacrine cells. Yet, for most of the >60 amacrine cell types, molecular identities and specialized functional attributes remain elusive. Here, we developed an intersectional genetic strategy to target a group of wide-field amacrine cells (WACs) in mouse retina that co-express the transcription factor Bhlhe22 and the Kappa Opioid Receptor (KOR; B/K WACs). B/K WACs feature straight, unbranched dendrites spanning over 0.5 mm (∼15° visual angle) and produce non-spiking responses to either light increments or decrements. Two-photon dendritic population imaging reveals Ca2+signals tuned to the physical orientations of B/K WAC dendrites, signifying a robust structure-function alignment. B/K WACs establish divergent connections with multiple retinal neurons, including unexpected connections with non-orientation-tuned ganglion cells and bipolar cells. Our work sets the stage for future comprehensive investigations of the most enigmatic group of retinal neurons: WACs.
MetDecode: methylation-based deconvolution of cell-free DNA for non-invasive multi-cancer typing
Authors: Sudhakaran Dhanya , Tuveri Stefania , Passemiers Antoine , Jatsenko Tatjana , Laga Tina , Punie Kevin , Tejpar Sabine , Coosemans An , Nieuwenhuysen Els Van , Timmerman Dirk , Floris Giuseppe , Rompuy Anne-Sophie Van , Sagaert Xavier , Testa Antonia , Ficherova Daniela , Raimondi Daniele , Amant Frederic , Lenaerts Liesbeth , Moreau Yves , Vermeesch Joris R. 
Published: December 2023

AbstractCell-free DNA (cfDNA) mediated early cancer detection is based on detecting alterations in the cfDNA components. However, the underlying pathology can usually not be readily identified. We built a reference atlas based on the methylome of multiple cancer and blood-cell types and developed MetDecode, an epigenetic signature-based deconvolution algorithm. MetDecode accurately estimates the tumour proportion inin-silicomixtures and identifies the tissue of origin in 81.25% cfDNA samples from cancer patients. This method will complement cancer screening programs and guide clinical follow-up.
Bidirectional Modulation Of Synaptic Transmission By Insulin-Like Growth Factor I
Authors: Noriega-Prieto José Antonio , Maglio Laura Eva , Dávila José Carlos , Gutiérrez Antonia , Alemán Ignacio Torres , de Sevilla David Fernández 
Published: December 2023

ABSTRACTInsulin-like growth factor-I (IGF-I) plays a key role in the modulation of synaptic plasticity, and is an essential factor in learning and memory processes. Indeed, we have demonstrated that IGF-IR activation induces long-term potentiation (LTP) of synaptic transmission (LTPIGF-I) both in the barrel cortex, improving object recognition (Noriega-Prieto et al., 2021), and in the prefrontal cortex, facilitating the extinction of conditioned fear (Maglio et al., 2021). However, during aging, IGF-I levels are decreased, and the effect of this decrease in the induction of synaptic plasticity remains unknown. Here we show that the induction of NMDAR-dependent LTP at layer 2/3 PNs of the mouse barrel cortex is favored or prevented by IGF-I (10nM) or IGF-I (7nM), respectively, when IGF-I is applied 1 hour before the induction of Hebbian LTP. Analyzing the cellular basis of this bidirectional control of synaptic plasticity, we observed that while 10nM IGF-I generates LTP (LTPIGF-I) of the post-synaptic potentials (PSPs) by inducing LTD of the inhibitory post-synaptic currents (IPSCs), 7nM IGF-I generates LTD of the PSPs (LTDIGF-I) by inducing LTD of the excitatory post-synaptic currents (EPSCs). This bidirectional effect of IGF-I is supported by the observation of IGF-IR immunoreactivity at both excitatory and inhibitory synapses. Therefore, IGF-I controls the induction of Hebbian NMDAR-dependent plasticity depending on its concentration, revealing novel cellular mechanisms of IGF-I on synaptic plasticity and in the learning and memory machinery of the brain.SIGNIFICANCE STATEMENTInsulin-like growth factor-I (IGF-I) signalling plays key regulatory roles in multiple processes of brain physiology, such as learning and memory, and brain pathology, such as Alzheimer disease. Yet, the underlying mechanisms remain largely undefined. Here we demonstrate that IGF-I signalling triggers long-term potentiation (LTP) or long-term depression (LTD) of synaptic transmission at cortical synapses in a concentration dependent manner, thus regulating the induction of Hebbian synaptic plasticity. The present work represents an important conceptual advance in our knowledge of the cellular basis of IGF-I signalling in brain function.
The puzzling association between accounting conservatism and corporate social responsibility
Authors: Daryaei Abbas Ali , Fattahi Yasin , Aldbs Ali 
Published: December 2023

PurposeThe purpose of this paper is to focus on exploring the mutual impact of accounting conservatism and corporate social responsibility (CSR).Design/methodology/approachTo empirically assess the theoretical arguments the authors estimate a simultaneous equations system for accounting conservatism and corporate social responsibility determination by two-stage least squares in a sample of 175 firms listed on the Tehran Stock Exchange (TSE) for the period 2009–2019.FindingsThe results of the present study showed that accountability in companies listed on the TSE has led to an increase in the use of conservative practices. Therefore arguably, companies that seek CSR activities are more conservative in preparing and presenting financial reports. Also, companies that engage in conservative practices for the benefit of stakeholders are better able to implement CSR activities to meet stakeholder obligations. These results show a two-way relationship between CSR and accounting conservatism.Practical implicationsAccording to the results obtained from this study and the elimination of conservatism from the qualitative features of financial reporting in International Accounting Standards, it is recommended for the trustees and authorities of national accounting standards to decide whether this qualitative feature is effective or not.Originality/valueFurthermore, the findings of this study suggest that the application of corporate social responsibility theories calls for more inquiry.
Authenticity, health concern and sustainable intelligence in the farm restaurant context: applying extended theory of planned behaviour
Authors: Girish V.G. , Saha Anindita , Immanuel R. Rex , Kim Bona 
Published: December 2023

Purpose The study aims to analyse the structural relationships of authenticity, health concern and sustainable intelligence in the farm restaurant context. Different types of restaurants have been targeted to understand consumer behaviour; however, the behavioural intention of visitors dining at the farm restaurants was rarely explored.Design/methodology/approach With the backdrop of the theory of planned behaviour (TPB), this study highlights the understanding, particularly on personal values associated with the behavioural intention of consumers visiting the farm restaurant. Data were collected, circulating questionnaires onsite and online at a farm restaurant. Structural equation modelling was employed to analyse the data.Findings Study findings reveal that personal values such as authenticity, health concern and sustainable intelligence positively influence the mediating constructs of TPB towards behavioural intention to revisit the farm restaurant.Originality/value This research might be the first one, exclusively focused on understanding the behavioural intention of the consumers visiting the farm restaurant, based on their personal values. This study specifically enriches the farm restaurant literature from the academic perspective and offers insights to farm restaurant owners and managers about the priorities of the consumers visiting the farm restaurant.
Proactive personality and turnover intentions of nurses: the roles of professional recognition and their supervisor’s proactive personality
Authors: Kim Mijeong , Oh Jinuk 
Published: December 2023

PurposeGiven that the relationship between proactive personality and turnover intention is not straightforward in the literature, the authors address two research questions focusing on the nursing profession: does proactive personality negatively influence nurses' turnover intention by alleviating their lack of professional recognition? And does a supervisor’s proactive personality act as a boundary condition for the mediating effects of the lack of professional recognition in the link between proactive personality and turnover intentions?Design/methodology/approachA moderated mediation model linking proactive personality and turnover intentions was developed and tested on a sample of 579 nurses in 88 work units in general hospitals in South Korea.FindingsThe results of multilevel path analysis reveal that proactive personality has a negative indirect relationship with turnover intention via lack of professional recognition. Additionally, the indirect relationship is strengthened when the supervisor’s proactive personality is low.Originality/valueThese findings provide valuable empirical evidence on the inconclusive relationship between proactive personality and turnover intention by highlighting the role of proactive personality in attenuating the influence of negative occupational factors. Moreover, proactive personality as a boundary condition for the aforementioned relationship was empirically examined.
Accounting conservatism, timeliness and interactions in the Scandinavian stock markets
Authors: Kyriakou Maria I. , Koulakiotis Athanasios , Babalos Vassilios 
Published: December 2023

PurposeThe purpose of this study is to examine within a unified framework the timeliness and conservatism of accounting disclosure accommodating the transmission of news among the Scandinavian stock markets.Design/methodology/approachTo this end the authors have used an augmented ordinary least squares (OLS) approach and univariate generalized autoregressive conditional heteroskedastic and vector autoregressive (VAR) modeling. The sample covers the period from 1987 to 2020, totaling 1452 observations. The sample was collected from the datastream database.FindingsThe empirical results of this study are consistent with previous findings and provide evidence that accounting reporting is timely and conservative while news is transmitted amongst the Scandinavian stock markets.Practical implicationsThe findings could be important for investors, firms and regulators since failure of considering information that is derived from more advanced approaches could result in lower quality of annual reports of companies.Originality/valueThe authors examined the relationship between earnings yield and conditional risk using an augmented OLS model and the transmission of news among Scandinavian stock markets using a VAR model.