bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza vaccine effectiveness in Europe: Results from the 2022–2023 VEBIS (Vaccine Effectiveness, Burden and Impact Studies) primary care multicentre study
Authors: Maurel Marine , Pozo Francisco , Pérez‐Gimeno Gloria , Buda Silke , Sève Noémie , Oroszi Beatrix , Hooiveld Mariette , Gomez Verónica , Domegan Lisa , Martínez‐Baz Iván , Ilić Maja , Carnahan Anna Sara , Mihai Maria Elena , Martínez Ana , Goerlitz Luise , Enouf Vincent , Horváth Judit Krisztina , Dijkstra Frederika , Rodrigues Ana Paula , Bennett Charlene , Trobajo‐Sanmartín Camino , Mlinarić Ivan , Latorre‐Margalef Neus , Ivanciuc Alina , Lopez Aurora , Dürrwald Ralf , Falchi Alessandra , Túri Gergő , Meijer Adam , Melo Aryse , O'Donnell Joan , Castilla Jesús , Vučina Vesna Višekruna , Hagey Tove Samuelsson , Lazar Mihaela , Kaczmarek Marlena , Bacci Sabrina , Kissling Esther ,   VEBIS study team
Published: January 2024

AbstractBackgroundInfluenza A(H3N2) viruses dominated early in the 2022–2023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test‐negative study.Materials and MethodsPrimary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We measured VE against any influenza, influenza (sub)type and clade, by age group, by influenza vaccine target group and by time since vaccination, using logistic regression.ResultsWe included 38 058 patients, of which 3786 were influenza A(H3N2), 1548 influenza A(H1N1)pdm09 and 3275 influenza B cases. Against influenza A(H3N2), VE was 36% (95% CI: 25–45) among all ages and ranged between 30% and 52% by age group and target group. VE against influenza A(H3N2) clade 2b was 38% (95% CI: 25–49). Overall, VE against influenza A(H1N1)pdm09 was 46% (95% CI: 35–56) and ranged between 29% and 59% by age group and target group. VE against influenza A(H1N1)pdm09 clade 5a.2a was 56% (95% CI: 46–65) and 79% (95% CI: 64–88) against clade 5a.2a.1. VE against influenza B was 76% (95% CI: 70–81); overall, 84%, 72% and 71% were among 0–14‐year‐olds, 15–64‐year‐olds and those in the influenza vaccination target group, respectively. VE against influenza B with a position 197 mutation of the hemagglutinin (HA) gene was 79% (95% CI: 73–85) and 90% (95% CI: 85–94) without this mutationConclusionThe 2022–2023 end‐of‐season results from the VEBIS network at primary care level showed high VE among children and against influenza B, with lower VE against influenza A(H1N1)pdm09 and A(H3N2).
Chemical co‐precipitation synthesis of high‐entropy rare‐earth silicate nanopowders
Authors: Wei Peng , Zhao Shixin , Zhuang Lei , Yu Hulei , Qin Yexia , Chu Yanhui 
Published: January 2024

AbstractThe synthesis of high‐quality nanopowders is crucial to developing high‐performance, high‐entropy rare‐earth silicates (HERESs). Herein, we report the synthesis of HERES nanopowders, including high‐entropy rare‐earth monosilicates (HEREMs) and high‐entropy rare‐earth disilicates (HEREDs), via a simple chemical co‐precipitation method for the first time. By rationally optimizing the synthesis conditions, monoclinic HEREM nanopowders can be well synthesized with highly uniform element distributions. The formation of HEREM nanoparticles is governed by the production of the precursor from the co‐precipitation reactions between rare‐earth hydroxide and silicic acid at the atomic scale, followed by the dehydration of precursor skeletons. Furthermore, the validation of using this approach to prepare HERED nanopowders is also confirmed. This research will open up a new research area in synthesizing HERES nanopowders.
Periodontitis and hypertension are linked through systemic inflammation: A 5‐year longitudinal study
Authors: Torrungruang Kitti , Vathesatogkit Prin , Mahanonda Rangsini , Thienpramuk Lalitsara 
Published: January 2024

AbstractAimTo investigate the associations between periodontitis and hypertension and potential mediation via systemic inflammation through a 5‐year longitudinal study.Materials and MethodsThe severity and extent of periodontitis were determined using probing depth (PD). Oral hygiene was assessed using plaque scores. The associations between periodontal variables and 5‐year blood pressure changes or incident hypertension were analysed using linear or Poisson regression, adjusting for potential confounders. Mediation analysis of two systemic inflammatory biomarkers, namely white blood cell count (WBC) and C‐reactive protein (CRP) levels, was performed.ResultsThe study population included 901 hypertension‐free participants, aged 50–73 years. Greater mean PD, higher percentage of sites with PD ≥ 6 mm and poor oral hygiene were associated with elevated systolic blood pressure and increased hypertension risk (relative risks = 1.17 [95% confidence interval [CI]: 1.02–1.34], 1.13 [95% CI: 1.02–1.26] and 1.08 [95% CI: 1.03–1.13], respectively). Periodontitis and poor oral hygiene were associated with higher WBC and CRP levels (p < .05), which, in turn, were associated with increased hypertension risk (p < .05). WBC and CRP jointly mediated 14.1%–26.9% of the associations between periodontal variables and incident hypertension.ConclusionsPeriodontitis and poor oral hygiene were associated with increased hypertension risk, and systemic inflammation was, in part, a mediator of these associations.
Comparison of holotomographic microscopy and coherence‐controlled holographic microscopy
Authors: Chvalova Vera , Vomastek Tomas , Grousl Tomas 
Published: January 2024

AbstractQuantitative phase imaging (QPI) is a powerful tool for label‐free visualisation of living cells. Here, we compare two QPI microscopes – the Telight Q‐Phase microscope and the Nanolive 3D Cell Explorer‐fluo microscope. Both systems provide unbiased information about cell morphology, such as individual cell dry mass, perimeter and area. The Q‐Phase microscope uses artefact‐free, coherence‐controlled holographic imaging technology to visualise cells in real time with minimal phototoxicity. The 3D Cell Explorer‐fluo employs laser‐based holotomography to reconstruct 3D images of living cells, visualising their internal structures and dynamics. Here, we analysed the strengths and limitations of both microscopes when examining two morphologically distinct cell lines – the cuboidal epithelial MDCK cells which form multicellular clusters and solitary growing Rat2 fibroblasts. We focus mainly on the ability of the devices to generate images suitable for single‐cell segmentation by the built‐in software, and we discuss the segmentation results and quantitative data generated from the segmented images. We show that both microscopes offer slightly different advantages, and the choice between them depends on the specific requirements and goals of the user.
Healthcare provision for Swedish persons with intellectual and developmental disabilities
Authors: Björne Petra , Flygare Wallén Eva 
Published: January 2024

AbstractThis paper aims to give a short description of Swedish healthcare provision for persons with intellectual and developmental disabilities (IDD). Swedish persons with IDD should have access to the general healthcare system on the same terms as the general population, and thereby enjoy equal opportunities for healthcare of good quality. Reports from government agencies and interest groups, however, describe a decentralised and fragmented healthcare system that requires significant coordination; a lack of adjustments; a lack of specialised healthcare professionals; and gaps in healthcare provision. Research in recent years has reported unequal access to planned healthcare; excess mortality and premature deaths; and insufficient or inadequate support in end‐of‐life care. We conclude that health inequalities and healthcare challenges faced by Swedish persons with IDD might be caused by obstacles at several structural levels. Allowing persons with IDD to access timely and adequate healthcare requires the development of better opportunities for coordination of healthcare and social services, as well as training for healthcare professionals and direct support staff.
Cognitive performance of air personnel following sleep deprivation
Authors: Algranati Daniela , Nakdimon Idan , Levkovsky Anna , Gordon Barak , Ben‐Ari Oded 
Published: January 2024

SummaryAir forces have developed several methods for reducing fatigue‐related accidents. In the Israeli Air Force, the “Dead Tired” workshop was developed with the purpose of presenting aircrew with their objective performance under sleep deprivation conditions. The aim of this study was to examine the cognitive abilities of both aircrew and unmanned aerial vehicle operators, both objectively and subjectively. All Israeli aircrew and unmanned aerial vehicle operators participated in a “Dead Tired” workshop. During the workshop, the participants performed the Psychomotor Vigilance Task, a task that tests their attention abilities, while gathering information on their subjective sleepiness in the form of a Karolinska Sleepiness Scale. Data of 366 participants (25 females), of whom 187 were unmanned aerial vehicle operators and 179 were aircrew, were obtained; and the mean age was 21.8 ± 1.2 years (range 19–26 years). A significant decline in task performance was seen following 20 hr of wakefulness in both unmanned aerial vehicle operators and aircrew (p < 0.001). Unmanned aerial vehicle operators' performance was significantly better throughout the majority of the workshop (p < 0.001). Recovery after the full‐night's sleep was seen for unmanned aerial vehicle operators, but not for aircrew (p = 0.008). A high correlation was seen between Psychomotor Vigilance Task performance and Karolinska Sleepiness Scale responses (correlation coefficient = 0.93). Sleep deprivation negatively impacted the performance of both groups of participants. Unmanned aerial vehicle operators were found to be more resilient to the effects of sleep deprivation and were quicker to recover in comparison to aircrew.
Aging later but faster: how StCDF1 regulates senescence in Solanum tuberosum
Authors: Shi Li , de Biolley Laura , Shaikh Maroof Ahmed , de Vries Michiel E. , Mittmann Sybille Ursula , Visser Richard G. F. , Prat Salome , Bachem Christian W. B. 
Published: January 2024

Summary
In potato, maturity is assessed by leaf senescence, which, in turn, affects yield and tuber quality traits. Previously, we showed that the CYCLING DOF FACTOR1 (StCDF1) locus controls leaf maturity in addition to the timing of tuberization. Here, we provide evidence that StCDF1 controls senescence onset separately from senescence progression and the total life cycle duration.
We used molecular–biological approaches (DNA‐Affinity Purification Sequencing) to identify a direct downstream target of StCDF1, named ORESARA1 (StORE1S02), which is a NAC transcription factor acting as a positive senescence regulator.
By overexpressing StORE1S02 in the long life cycle genotype, early onset of senescence was shown, but the total life cycle remained long. At the same time, StORE1S02 knockdown lines have a delayed senescence onset. Furthermore, we show that StORE1 proteins play an indirect role in sugar transport from source to sink by regulating expression of SWEET sugar efflux transporters during leaf senescence.
This study clarifies the important link between tuber formation and senescence and provides insight into the molecular regulatory network of potato leaf senescence onset. We propose a complex role of StCDF1 in the regulation of potato plant senescence.
Physicochemical characterization of novel biomass‐based microcrystalline cellulose derived from agro‐industrial residues of Rosa indica petals
Authors: G Suganya Priyadharshini , Sivanantham Gokulkumar , Divakaran Divya , Suyambulingam Indran , P Senthamaraikannan , Murugan Aravindh , M.R. Sanjay , Siengchin Suchart 
Published: January 2024

AbstractThe growing demand for sustainable materials is driving the adoption of microcrystalline cellulose (MCC) from renewable plant sources. This study investigated the isolation of MCC from Rosa indica petal (RIP) waste via acid hydrolysis. RIP was pretreated with alkali extraction and bleaching prior to acid hydrolysis. Chemical analysis revealed the composition of pretreated RIP was 79.56 wt.% cellulose, 9.87 wt.% hemicelluloses, and 5.69 wt.% lignin. Fourier‐transform infrared spectroscopy (FTIR) showed reduced peaks at 3332.88, 2851.95, and 1577.75 cm−1 after alkali treatment, indicating removal of hemicelluloses and lignin. X‐ray diffraction (XRD) found the crystallinity index of the isolated Rose indica petals cellulose (RIPC) MCC was 72.31%, suggesting effective purification. Thermogravimetric analysis (TGA) revealed RIPC MCC had a decomposition temperature of 296.65°C, superior to raw RIP at 211.25°C. In addition, atomic force microscopy (AFM) and scanning electron microscopy (SEM) showed RIPC MCC had fibrous morphology with fiber diameters ranging from 16.2–22.4 nm. In summary, RIPC MCC with high purity, crystallinity and thermal stability was successfully isolated from RIP waste via acid hydrolysis. The high performance of RIPC MCC demonstrates the potential of RIP leftovers as a renewable source for MCC production. RIPC MCC could serve as a promising reinforcement filler in nanocomposites due to its advantageous properties.
Risk‐based thinking for extreme events: What do terrorism and climate change have in common?
Authors: Stewart Mark 
Published: January 2024

AbstractTerrorism and climate change debates are often characterized by worst‐case thinking, cost neglect, probability neglect, and avoidance of the notion of acceptable risk. This is not unexpected when dealing with extreme events. However, it can result in a frightened public, costly policy outcomes, and wasteful expenditures. The paper will describe how risk‐based approaches are well suited to infrastructure decision‐making for extreme events. Risk management concepts will be illustrated with current research of risk‐based assessment of climate adaptation engineering strategies including designing new houses in Australia subject to cyclones and extreme wind events. It will be shown that small improvements to house designs at a one‐off cost of several thousand dollars per house can reduce damage risks by 70%–80% and achieve billions of dollars of net benefit for community resilience—this helps offset some the predicted adverse effects of climate change for a modest cost. The effect of risk perceptions, insurance, and economic incentives is explored for another climate adaption measure. The paper will also highlight that there is much to be optimistic about the future, and in the ability of risk‐based thinking to meet many challenges.
A compendium of evidence‐based practice instruments for nursing education, practice and research
Authors: Halm Margo A. 
Published: January 2024

AbstractBackgroundEvidence‐based practice (EBP) is a cornerstone for safe, high‐quality care. Implementation science recognizes that many factors influence the successful use of EBP, from attitudes and beliefs, self‐efficacy, and knowledge and skills to contextual factors related to unit and organizational culture. This integrative review aimed to identify valid and reliable instruments measuring critical EBP domains with nursing professionals.MethodsA systematic search of the literature was conducted. CINAHL, PubMed, EMBASE, Cochrane, and Joanna Briggs were searched to identify original research publications testing the reliability and validity of EBP nursing instruments.ResultsOf 347 records, 48 studies representing 50 instruments were identified as having undergone psychometric testing, thus meeting the inclusion criteria. Most instruments were validated in English‐speaking countries. Content validity, construct validity, and internal consistency standards were met for 70%, 62%, and 94% of instruments, respectively. Limited testing was found for other types of validity, test–retest reliability, acceptability, feasibility, or responsivity and sensitivity, thus representing gaps in psychometric validation. Less than 20% of instruments have been translated to other languages limiting their use to advance EBP worldwide.Linking Evidence to ActionEighty‐two percent of instruments met minimal psychometric standards and are sound for education, practice, and research. Expanding psychometric testing and utilizing validated EBP instruments will further the EBP movement to improve global population health.
Numerical Study of Eccentric Jet Impingement Cooling on a Heated Cylindrical Surface
Authors: Chauhan Vikash Kumar Singh , Kumari Karuna , Kumar Pankaj , Venkiteswaran Vinod Kumar , Awad Mohamed M. 
Published: January 2024

Abstract
This article presents a comprehensive numerical analysis of the effects of cooling a cylinder using an eccentric slot jet impingement cooling (SJIC). The study focuses on examining the thermal and fluid behavior when the slot jet is offcenter, during impingement cooling. Several turbulence models from the k–ε and k–ω families were compared by evaluating the local Nusselt number profiles at different locations around the cylinder, and these results were compared to experimental data. The findings indicate that the SST k–ω model outperforms the other turbulence models in estimating the Nusselt number in the stagnation region, while the standard k–ω model shows improved performance elsewhere on the cylinder. Furthermore, this study reveals a decrease in the maximum local Nusselt number and a shift in the direction of the nozzle displacement. The presence of swirling/recirculating fluid at the trailing end of the cylinder enhances heat transfer near the back end of the cylinder. The separation and the reattachment of the fluid stream differ depending on the Reynolds number, with low Reynolds numbers resulting in reattachment on the side of the slot jet and higher Reynolds numbers leading to reattachment in the opposite direction. Additionally, the length of the recirculation and swirling zones increases as the nozzle-to-cylinder spacing (H/S) increases. However, as the eccentricity (E/S) increases, the size of the swirl circulation zones decreases and completely vanishes for E/S = 4. This study provides valuable insights for optimal cooling design.
Nosocomial surveillance of multidrug-resistant
Acinetobacter baumannii
: a genomic epidemiological study
Authors: Duan Zhimei , Li Xuming , Li Song , Zhou Hui , Hu Long , Xia Han , Xie Lixin , Xie Fei 
Published: January 2024

ABSTRACT

Acinetobacter baumannii
is a major opportunistic pathogen causing hospital-acquired infections, and it is imperative to comprehend its evolutionary and epidemiological dynamics in hospitals to prevent and control nosocomial transmission. Here, we present a comprehensive genomic epidemiological study involving the genomic sequencing and antibiotic resistance profiling of 634
A
.
baumannii
strains isolated from seven intensive care units (ICUs) of a Chinese general hospital over 2 consecutive years. Our study reveals that ST2 is highly dominant (90.54%) in the ICUs, with 98.90% of the ST2 exhibiting multidrug resistant or extensively drug resistant. Phylogenetic analyses of newly sequenced genomes and public data suggest that nosocomial isolates originated outside the hospital but evolved inside. The major lineages appear to be stable, with 9 of the 28 identified nosocomial epidemic clones infecting over 60% of the affected patients. However, outbreaks of two highly evolved clones have been observed in different hospitals, suggesting significant inter-hospital transmission chains. By coupling patient medical records and genomic divergence of the ST2, we found that cross-ward patient transfer played a crucial role in pathogen’s nosocomial transmission. Additionally, we identified 831 potential adaptive evolutionary loci and 44 associated genes by grouping and comparing the genomes of clones with different prevalence. Overall, our study provides a comprehensive and contemporary survey on the epidemiology and genomic evolution of
A. baumannii
in a large Chinese general hospital. These findings shed light on the nosocomial evolution and transmission of
A. baumannii
and offers valuable information for transmission prevention and antibiotic therapy.

IMPORTANCE

This study delved into the genomic evolution and transmission of nosocomial
Acinetobacter baumannii
on a large scale, spanning both an extended time period and the largest sample size to date. Through molecular epidemiological investigations based on genomics, we can directly trace the origin of the pathogen, detecting and monitoring outbreaks of infectious diseases in a timely manner, and ensuring public health safety. In addition, this study also collects a large amount of genomic and antibiotic resistance detection data, which is helpful for phenotype prediction based on genomic sequencing. It enables patients to receive personalized antibiotic treatment quickly, helps doctors select antibiotics more accurately, and contributes to reducing the use of antibiotics and lowering the risk of antibiotic resistance development.
Analysis of SARS-CoV-2 genome evolutionary patterns
Authors: Gupta Shubhangi , Gupta Deepanshu , Bhatnagar Sonika 
Published: January 2024

ABSTRACT

The spread of SARS-CoV-2 virus accompanied by public availability of abundant sequence data provides a window for the determination of viral evolutionary patterns. In this study, SARS-CoV-2 genome sequences were collected from seven countries in the period January 2020–December 2022. The sequences were classified into three phases, namely, pre-vaccination, post-vaccination, and recent period. Comparison was performed between these phases based on parameters like mutation rates, selection pressure (d
N
/d
S
ratio), and transition to transversion ratios (T
i
/T
v
). Similar comparisons were performed among SARS-CoV-2 variants. Statistical significance was tested using Graphpad unpaired
t
-test. The analysis showed an increase in the percent genomic mutation rates post-vaccination and in recent periods across all countries from the pre-vaccination sequences. Mutation rates were highest in NSP3, S, N, and NSP12b before and increased further after vaccination. NSP4 showed the largest change in mutation rates after vaccination. The d
N
/d
S
ratios showed purifying selection that shifted toward neutral selection after vaccination. N, ORF8, ORF3a, and ORF10 were under highest positive selection before vaccination. Shift toward neutral selection was driven by E, NSP3, and ORF7a in the after vaccination set. In recent sequences, the largest d
N
/d
S
change was observed in E, NSP1, and NSP13. The T
i
/T
v
ratios decreased with time. C→U and G→U were the most frequent transitions and transversions. However, U→G was the most frequent transversion in recent period. The Omicron variant had the highest genomic mutation rates, while Delta showed the highest d
N
/d
S
ratio. Protein-wise d
N
/d
S
ratio was also seen to vary across the different variants.

IMPORTANCE
To the best of our knowledge, there exists no other large-scale study of the genomic and protein-wise mutation patterns during the time course of evolution in different countries. Analyzing the SARS-CoV-2 evolutionary patterns in view of the varying spatial, temporal, and biological signals is important for diagnostics, therapeutics, and pharmacovigilance of SARS-CoV-2.