bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social factors influencing behavioral intentions to vaccinate: personality traits and cues to action
Authors: Li Zeming , Sun Xinying 
Published: January 2025

ObjectivesThis study integrates the Five-Factor Model (FFM) of personality traits with the Health Belief Model (HBM) to examine associations among personality traits, cues to action, and vaccination intentions.MethodAn online survey was conducted in April 2021, with 2,098 participants (mean age = 31.22 years, SD = 8.29) completing the study. The questionnaire assessed HBM constructs and the FFM personality traits. Spearman correlation coefficients were used to evaluate associations among ordinal variables, while Structural Equation Modeling (SEM) explored complex relationships between latent variables.ResultsThe findings indicate that self-efficacy (β = 0.198) and perceived barriers (β = 0.515) exert the most significant direct positive influences on vaccination intentions. Cues to action, particularly recommendations from family members (β = 0.113) and doctors (β = 0.092), also significantly affect vaccination intentions. Notably, personality traits indirectly influence vaccination intentions through self-efficacy and perceived barriers. Furthermore, agreeableness most significantly affects family suggestions, while neuroticism strongly influences recommendations from authority figures and healthcare providers, with extraversion notably impacting suggestions from peers.ConclusionsThe study highlights the influence of personality traits on cues to action, with neuroticism linked to authority influence, extraversion to peer influence, and agreeableness to familial influence. These findings emphasize the importance of incorporating individual differences into public health policies and vaccination promotion strategies. Future research should further explore the effects of diverse personality traits and community-specific profiles on vaccination behaviors to enhance intervention effectiveness.
Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper
Authors: Joury Easter , Nakhleh Eliana , Beveridge Ed , Tracy Derek , Heidari Ellie , Shiers David , Vereeken Silke , Peckham Emily , Gilbody Simon , Das-Munshi Jayati , Fortune Farida , Aggarwal Vishal R. , Mishu Masuma , Firth Joseph , Bhui Kamaldeep 
Published: January 2025

BackgroundClustering mental, physical and oral conditions reduce drastically the life expectancy. These conditions are precipitated and perpetuated by adverse social, economic, environmental, political and healthcare contextual factors, and sustained through bidirectional interactions forming potentially a ‘syndemic’. No previous study has investigated such potential syndemic. Thus, the present project aimed to (i) test for syndemic interactions between social adversity (socioeconomic adversity and traumatic events) and mental, physical and oral multimorbidity using the syndemic theoretical framework; and (ii) determine whether the syndemic relationships vary by age, sex and ethnicity.MethodsData from three large-scale population-based databases: UK BioBank, US National Health and Nutrition Examination Survey (NHANES) and the Research with East London Adolescents Community Health Survey (RELACHS) will be analysed. Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. Such syndemic care aims to address the social determinants of health, whilst simultaneously managing all interlocked conditions.
The experience of bodily image for patients with left ventricular assist device
Authors: Milaniak Irena , Witkowska Emilia , Cebula Marta , Tomsia Paulina , Wasilewski Grzegorz , Górkiewicz-Kot Izabela , Wiśniowska-Śmiałek Sylwia , Kaleta Michał , Wierzbicki Karol 
Published: January 2025

IntroductionMechanical Cardiac Support and Left Ventricular Assist Devices (LVAD) have been demonstrated to prolong Heart Failure patients' survival and improve their quality of life. LVAD implantation has a considerable effect on patients' body image. Patients find it hard to accept the device as an extension of their body, especially the driveline. The study aimed to examine the relationships between anxiety and depressive symptoms, acceptance of illness, beliefs about pain control, and quality of life with body image among LVAD-implanted patients.MethodsThe cross-sectional study included 54 conveniently recruited patients who completed the Body Image Scale, SF-12, Acceptance of Illness Scale, Beliefs about Pain Control Questionnaire, NRS, HADS, and demographic and clinical data. Multiple regression analyses examined the associations between the research variable.ResultsThe mean Age of the participants was 59.64 (SD=9.63), and 96.3% were men. The mean scores were: Body Image Scale – 28.33 (SD=5,91); Acceptance of Illness Scale – 25.51 (SD=5.92); beliefs about pain control: internal factors – 15.85 (SD=4.96), the influence of physicians – 17.57 (SD=3.15), random events – 14.37(SD=3.32), NRS=2.80(SD=1.86), HADS anxiety – 5.33 (SD=4.12), HADS depression – 4.66 (SD=3.10), SF12MCS-45.49 (SD=6.48), SF-12PCS-41,33 (SD=6.48). The presence of anxiety and depressive symptoms and complications after LVAD significantly predicted low body image concerns.DiscussionHealthcare professionals should be aware of challenges regarding body image faced by LVAD-implanted patients and address related factors, especially anxiety and depression.
The effect of a one-time mindfulness intervention on body and mind in healthy adolescents using multimodal measurements
Authors: Ecker Angelika , Fritsch Charlotte , Schleicher Daniel , Jacob Ricarda , Kandsperger Stephanie , Brunner Romuald , Jarvers Irina 
Published: January 2025

BackgroundMindfulness-based interventions can improve psychological well-being and reduce symptoms of mental burden, including among adolescents. Relationships between basic mindfulness (trait mindfulness) and the immediate effects of a single mindfulness intervention have not been thoroughly researched, especially in adolescents. In this study, we aimed to elucidate these aspects by using a multimodal approach—measuring the effect of a single mindfulness intervention on both subjective and physiological parameters.MethodsA total of 78 healthy adolescents (12–19 years of age, 50% female) were assigned to either a mindfulness or an active control group. Before and after the interventions, subjective parameters (mood, stress, and state mindfulness) were assessed using bipolar visual analogue scales. Physiological parameters (heart rate and heart rate variability) were measured before and during the interventions. Participants also completed the Self-Compassion Scale (SCS-D) with the subscale “mindfulness” as an assessment of trait mindfulness, and the State-Trait Anxiety-Depression Inventory (STADI).ResultsOur results showed no significant interactions between time and intervention, either subjectively or physiologically. For heart rate, we found a main effect of time. For all subjective parameters, we observed a main effect of trait mindfulness. Age was a relevant factor for heart rate and state mindfulness, suggesting age effects. We also observed strong correlations between trait mindfulness, trait anxiety, and depression scores.ConclusionA single mindfulness intervention had no immediate observable effects in our healthy adolescent sample, and possible reasons for this finding are discussed. Nevertheless, the present data show the potential for increased resilience through mindfulness in adolescence.
Heart rate variability, a potential assessment tool for identifying anxiety, depression, and sleep disorders in elderly individuals
Authors: Liu Wenna , Wang Shutong , Gu Hanyang , Li Rong 
Published: January 2025

IntroductionThis study investigates how anxiety, depression, and sleep disorders impact heart rate variability (HRV) in the elderly, exploring the clinical implications of HRV changes.MethodsWe examined 355 patients (163 men, 192 women) at Xijing Hospital from July 2021 to December 2022 during health check-ups. Demographics were recorded, and emotional status was assessed using the Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD). The Pittsburgh Sleep Quality Scale (PSQI) evaluated sleep quality. Patients were categorized into groups A-G based on the presence of emotional states and sleep disorders. HRV indices—SDNN, SDANN, RMSSD, PNN50, LF/HF, LF, and HF—were analyzed using ANOVA and multivariate logistic regression.ResultsNo statistically significant differences were observed in demographic, clinical, and lifestyle factors across the eight groups. Variables assessed included age, sex, body mass index (BMI), fasting blood glucose, glycated hemoglobin (HbA1c), blood lipids, blood pressure, heart rate, and histories of smoking and alcohol consumption. Additionally, the presence of hypertension, diabetes, coronary heart disease, marital status, income, and education level were evaluated, with all showing equivalence (P &gt; 0.05). Significant differences in HRV indices were observed across groups, particularly in group G (patients with anxiety, depression and sleep disorders), which showed decreased HRV parameters except LF/HF, and group H (control group), which showed increased parameters, also except LF/HF (P &lt; 0.01). Anxiety was an independent risk factor for reduced SDNN, SDANN, and LF (P ≤ 0.01), and increased LF/HF ratio (P &lt; 0.01). Depression was linked to decreased SDNN, RMSSD, PNN50, and HF (P &lt; 0.05). Sleep disorders independently predicted reduced PNN50 and SDANN (P &lt; 0.01).ConclusionHRV indices of individuals with varying emotional states and sleep disorders exhibited varying degrees of decrease. Anxiety, depression, and sleep disorders presented a superimposed effect on HRV. SDNN, SDANN, RMSSD, PNN50, HF and LF of HRV are of great reference value in the diagnosis of emotional and sleep disorders. For elderly patients experiencing cognitive impairment, HRV is anticipated to serve as a convenient and effective tool for assessing mood and sleep disorders.
Impact of childhood trauma on cognitive function in patients with bipolar disorder
Authors: Zhang Zhiyang , Zhou Chenyu , Mao Zhen , Sun Yue , Zhao Lei , Li Tian , Wang Chuanyue , Bo Qijing 
Published: January 2025

BackgroundPatients with bipolar disorder (BD) frequently exhibit cognitive impairments. However, the association between childhood trauma as a risk factor for BD and cognitive deficits remains ambiguous.ObjectiveTo investigate the relationship between childhood trauma and cognitive function among patients with BD.MethodsThe study included 90 patients with BD and 94 healthy controls (HC). Childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ), and cognitive function was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The relationships between childhood trauma and cognitive function.ResultsIn BD group, childhood abuse and neglect were more prevalent than in HC group. Mood stabilizer use was positively associated with language abilities, while antipsychotic use negatively impacted attention. Emotional abuse predicted impaired immediate memory, with the number of episodes and valproate dosage negatively correlating with total RBANS scores, whereas education and mood stabilizer use showed positive correlations.ConclusionsThe incidence of childhood trauma was higher among BD than HC, and different types of childhood trauma had varying effects on different aspects of cognition. These studies will deepen the understanding of the complexity of BD and support the development of more effective treatment methods.
Stigma and fear during the COVID-19 pandemic: a qualitative study on the perceptions of healthcare workers in Canada and Singapore
Authors: Fahim Christine , Yu Chou Chuen , Cooper Jeanette , Theivendrampillai Suvabna , Lee Taehoon (Tom) , Wai-Ki Lau Michelle , Marquez Christine , Tang Bernard , Mathew Mathews , Sharma Malika , Wong Eric , O'Sullivan Tracey , Low James Alvin , Straus Sharon E. 
Published: January 2025

IntroductionWe sought to explore healthcare providers (HCPs)' perceptions of and experiences with stigma during the COVID-19 pandemic in Canada and Singapore.MethodsWe conducted a qualitative study (May 2020–February 2021) with HCPs in Canada and Singapore and developed a semi-structured interview guide rooted in the Health Stigma and Discrimination Framework (HSDF). We recruited participants online and through word of mouth via newsletters, blogs and social media. Participants were eligible to participate if they worked as a healthcare provider in Singapore or Canada during COVID-19. Following participant consent, data were recorded, transcribed verbatim, and coded using a framework approach. Coded data were charted into a framework matrix and used to compare themes in each country.ResultsWe conducted 51 interviews (23 in Canada; 28 in Singapore). HCPs perceived that patient fears coupled with mistrust of the health system impacted health behaviors. HCPs reported discrimination and stigmatization of population subsets. In Singapore, this included Chinese tourists and migrant workers and in Canada, this included people of Chinese ethnicity and people experiencing homelessness. This stigma was often attributed to pre-existing prejudices including perceptions that these populations were at increased risk of COVID-19 or not adhering to public health recommendations. HCPs feared spreading COVID-19 to family, peers and patients, often resulting in participants choosing to isolate from social circles. HCPs in both countries experienced occupation-based stigma, including stigma related to public health practices (masking, testing); in Canada, this intersected with race-based prejudice for participants of Chinese ethnicity. HCPs in both samples witnessed and experienced stigmatizing behavior; some participants also experienced discrimination.ConclusionsSecondary stigma related to occupation was experienced by HCPs during COVID-19. HCPs experienced intersecting stigma based on race/ethnicity and observed stigmatization of marginalized patient populations. Most themes were consistent across Canada and Singapore. Strategies to mitigate COVID-19 related stigma toward HCPs and at-risk patient populations are warranted.
Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal
Authors: Herrera Bobby Brooke , Chaplin Beth , MBoup Souleymane , Abdullahi Adam , He Michelle , Fisher Sydney M. , Akanmu Sulaimon , Chang Charlotte A. , Hamel Donald J. , Gupta Ravindra K. , Kanki Phyllis J. 
Published: January 2025

BackgroundThe COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. We investigated the potential role of pre-existing immunity in shaping the epidemiology of COVID-19 in Africa.MethodsPlasma collected from Senegalese female sex workers prior to the COVID-19 pandemic was screened for SARS-CoV-2 and human coronavirus (hCoV) antibodies by virion immunoblots. For antibody-reactive plasma, paired peripheral blood mononuclear cells were stimulated by fusion proteins and IFN-γ cellular responses were assessed via ELISPOT.ResultsWe observed substantial levels of pre-existing cross-reactive immunity to SARS-CoV-2, stemming from prior exposure to seasonal hCoVs. Our antibody analysis revealed a 23.5% (47/200) seroprevalence rate against SARS-CoV-2 nucleocapsid (N). These samples were then probed for antibodies against hCoV spike (S) and/or N antigens; 85.1% (40/47), 70.2% (33/47), and 95.7% (45/47) were antibody reactive against hCoV-229E, hCoV-OC43, or hCoV-HKU1, respectively. Our analysis of cellular responses also demonstrated cross-reactivity to SARS-CoV-2 with 80.0% (36/45) and 82.2% (37/45) showing IFN-γ responses against S and N, respectively. A unique pre-pandemic subject had cross-reactive SARS-CoV-2 S antibodies with detectable neutralization and cross-reactive cellular responses.ConclusionThese findings suggest that prior hCoV exposure may induce cross-reactive adaptive immunity, potentially contributing to protection against COVID-19. Our study provides unique data on the dynamics of hCoV and SARS-CoV-2 immunity in Senegal and underscores the importance of understanding the role of pre-existing immunity in shaping COVID-19 outcomes globally.
Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreationally active men
Authors: Salter Dawna , Yalamanchi Himana , Yalamanchi Aiswarya , Yalamanchi Amulya 
Published: January 2025

Extracts derived from Indian frankincense (Boswellia serrata) effectively reduce the pain and swelling associated with osteoarthritis. It is unknown whether the anti-inflammatory and analgesic properties of B. serrata extend to muscle and joint pain resulting from high-impact eccentric exercise. This pilot study evaluated the efficacy of a standardized B. serrata extract LI51202F1 (SBS) to decrease soreness and improve recovery after repeated bouts of downhill running (DHR) compared to placebo (PLA). In total, 50 men (mean age 28 ± 4) were randomly allocated to consume 60 mg SBS or PLA once per day for 10 days (6 days before, the day of, and 3 days after DHR). On day 7, delayed soreness was induced by three 15-min DHR episodes on a 10% declined treadmill. Visual analog scale (VAS) scores of joint and muscle soreness, in addition to the maximal weight lifted for a one-repetition leg extension (1RM-LE) were assessed at baseline (pre-supplementation) and on days 8, 9, and 10. Blood and urine samples collected at baseline, before, and after DHR were analyzed for inflammation-related biomarkers. VAS scores significantly increased while muscle strength decreased from baseline measures after DHR regardless of group assignment (main effect of time p &lt; 0.001). However, the subjects who received the supplement reported reduced muscle soreness on days 8, 9, and 10 compared to those who received the PLA. On day 9, peak soreness scores were lower in the SBS group than in the PLA group (p = 0.001). On day 10, the SBS group’s VAS scores were 8.0 ± 1.6 mm lower than the PLA group (p &lt; 0.001). Supplementation improved recovery time as the 1RM-LE returned to baseline strength by day 10, with the subjects who received the supplement lifting 3.4 ± 1.2 kg more than the PLA group (p = 0.006). The SBS-supplemented subjects reported less knee joint pain after DHR than the PLA group (p &lt; 0.05 on days 8, 9, and 10). C-reactive protein and interleukin-6 increased after DHR, but by day 10, SBS reduced these markers compared to the PLA (p &lt; 0.05). This study suggests that SBS, a novel, standardized extract derived from the gum resin of B. serrata, improves recovery and reduces soreness following high-impact eccentric exercise.Clinical Trial Registrationhttps://ctri.nic.in/Clinicaltrials/pubview2.php, Clinical Trial Registry of India (CTRI/2019/07/020323).
Факторы риска повторных сердечно-сосудистых событий после неосложненного острого коронарного синдрома
Authors: Берштейн Л. Л. , Лунина М. Д. , Евдокимов Д. C. , Найден Т. В. , Гумерова В. Е. , Кочанов И. Н. , Иванов А. А. , Болдуева С. А. , Реснянская Е. Д. , Збышевская Е. В. , Евтушенко А. Е. , Пилтакян В. Х. , Сайганов С. А. 
Published: January 2025

Цель. Выявить факторы риска повторных серьезных сердечно-сосудистых событий (МАСЕ) у пациентов с неосложненным острым коронарным синдромом (ОКС), имеющих атеросклеротическую бляшку брахиоцефальных артерий (АСБ БЦА) и получивших современное интервенционное и медикаментозное лечение. Материал и методы. В исследование включали пациентов с ОКС любого типа, которым выполнялось интервенционное лечение, имевших АСБ БЦА по данным ультразвукового исследования. Не включались пациенты, умершие или имевшие значимое кровотечение в период первичной госпитализации; с фракцией выброса левого желудочка <30%; тяжелой коморбидностью; с непереносимостью статинов. Оценивали полученные в период госпитализации клинические, инструментальные и лабораторные параметры, влияющие на сердечно-сосудистый прогноз после ОКС. После выписки осуществлялось наблюдение с регистрацией МАСЕ. Результаты. Обследован 251 пациент, 69,7% мужчин, в возрасте 65 [59; 73] лет. Период наблюдения составил 364 [235; 386] дня. Зарегистрировано 29 МАСЕ (11,6%): острый инфаркт миокарда (ОИМ) / госпитализация по поводу нестабильной стенокардии – 21 (8,4%); острый ишемический инсульт – 4 (1,6%); сердечная смерть – 4 (1,6%). Независимое влияние на риск MACE продемонстрировали сахарный диабет (СД), HR 3,13, 95% ДИ 1,49 - 6,60, р=0,003; курение (25 пачка/лет), HR 1,95, 95% ДИ 1,24 - 3,06, р=0,004; ОИМ в анамнезе, HR 2,26, 95% ДИ 1,07 - 4,77, р=0,033; инфаркт миокарда без подъема ST (ИМбпST), HR 2,39, 95% ДИ 1,09 - 5,24, р=0,029. В отдельной модели показано независимое прогностическое влияние индекса коморбидности Charlson. Одномоментная полная реваскуляризация при ИМбпST сопровождалась тенденцией к снижению числа МАСЕ (31% против 69%). Тяжесть атеросклероза БЦА не продемонстрировала влияния на МАСЕ. Заключение. Частота повторных МАСЕ в течение 1 г после неосложненного ОКС у пациентов с сопутствующим атеросклерозом БЦА достаточна высока. Наиболее значимые факторы риска МАСЕ - курение, СД, ОИМ в анамнезе, ОКС в форме ИМбпST. Данных о прогностической значимости тяжести атеросклероза БЦА не получено.
Показатели липидного спектра и системы гемостаза у пациентов с артериальной гипертензией и мультифокальным атеросклерозом, перенесших ишемический инсульт
Authors: Веденская С. С. , Смоленская О. Г. , Грачев В. Г. , Клячина Е. С. 
Published: January 2025

Абстракт Цель: оценить значение показателей липидного спектра, системы гемостаза и их взаимосвязь у пациентов с артериальной гипертензией (АГ) и мультифокальным атеросклеротическим поражением (МФАП), перенесших ишемический инсульт (ИИ). Материалы и методы. В исследование были включены 108 больных с АГ и МФАП, перенесших ИИ, медиана возраста 63 (57,0; 67). Из них 28 пациентов с достигнутыми целевыми показателями холестерина липопротеидов низкой плотности (ХС-ЛНП) <1,4 ммоль/л (группа 1), у 80 пациентов показатели ХС-ЛНП составили > 1,4 ммоль/л (группа 2). Пациенты обеих групп получали гиполипидемическую и сопоставимую антигипертензивную, антиагрегантную терапию. Для выявления нарушений гемостаза проводили тест на анализаторе «Регистратор тромбодинамики Т-2» (ООО «ГемаКор», Москва, Россия). Результаты. Большинство пациентов не имели целевых уровней ХС-ЛНП. Показатели классических локальных тестов гемостаза у пациентов обеих групп не выходили за пределы референсных значений и не отличались между группами. При исследовании коагуляционного звена гемостаза отмечались нарушения в сторону гиперкоагуляции у пациентов с недостигнутыми целевыми показателями липидного спектра. Анализ корреляционных взаимосвязей выявил зависимости между показателями липидного спектра, локальными и глобальными параметрами гемостаза, особенно у пациентов группы 2. Заключение. Пациенты с АГ и МФАП, перенесшие ишемический инсульт, нуждаются в интенсивной гиполипидемической терапии, так как часто не достигают целевых показателей липидного спектра. Это приводит к дальнейшим изменениям в глобальной системе гемостаза несмотря на постоянный прием антиагрегантной терапии. Наши результаты подтверждают целесообразность интенсификации липидснижающей терапии у пациентов с АГ и МФАП до целевых уровней с целью снижения сердечно-сосудистого риска в виде атеротромботических осложнений.