bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consciência jurídica relacional e anticorrupção: Lava Jato, interações em redes sociais e a coprodução da detração do direito no Brasil (2017-2019)
Authors: de Sa e Silva Fabio , Stewart Michael López 
Published: February 2025

Resumo
A partir de 2014, a política brasileira foi sacudida pela operação Lava Jato (LJ), uma iniciativa anticorrupção centrada no direito. A LJ expôs um grande esquema de corrupção na empresa nacional de petróleo, a Petrobras, envolvendo seus diretores, dirigentes de partidos políticos e grandes empreiteiras. Para alguns, a LJ representou um marco, um novo capítulo na história do Brasil, promovendo o “estado de direito” e um desejo coletivo de “acabar com a impunidade” na política e nos negócios. Para outros, a operação enfraqueceu a democracia e o estado de direito, abrindo caminho para uma liderança autocrática sob o ex-presidente Jair Bolsonaro. Este artigo contribui para esses debates ao analisar a LJ como um espaço de produção de “consciência jurídica.” Empiricamente, examina conversas lideradas por procuradores da LJ no Facebook entre 2017 e 2019. A questão central abordada é: “Quando os procuradores e o público falavam sobre a LJ, sobre o que falavam?” Os resultados se alinham às visões céticas sobre a operação, sugerindo que as interações entre os procuradores da LJ e seus seguidores no Facebook ajudaram a co-criar um quadro cultural que conflita com o “estado de direito.” Essas percepções oferecem implicações para estudos sobre consciência jurídica e esforços anticorrupção.
The gaps and opportunities for non-state actors in plastics circular economy approaches
Authors: Vince Joanna , Willis Kathryn A. 
Published: February 2025

Abstract
On all levels of governance, there have been varied policy responses to the marine plastic pollution issue. These responses include the development of innovative waste management, circular economy, extended producer responsibility and product stewardship approaches. Non-state actors play important roles in these approaches across global and national levels. Regulatory bodies often experience challenges with implementing sustainable, conservation measures, demonstrating that regulatory measures alone cannot generate the required change to effectively stop marine and terrestrial plastic pollution. Effective plastic pollution governance requires participation from non-state actors in its design, development and implementation. This article examines the gaps that exist in the governance of a plastics circular economy, including the focus on recycling and end-of-pipe/down-cycling solutions and the lack of attention on the other ‘Rs’ that are required for true circularity, for example, refuse, reduce, resell, reuse, repair, refurbish, remanufacture, repurpose and recover energy. We argue that non-state actors can help fill these gaps through multi-stakeholder partnerships, community-led plastic programmes and policies and environmentally and socially responsible industry-based solutions that utilise market-based initiatives. This article explores the roles of non-state actors in plastic policymaking and the gaps and opportunities for non-state actors in the development and implementation of holistic, integrated, ‘whole of life cycle’ and circular economy policies.
Sublethal effects of flonicamid on the population growth of the grain aphid Rhopalosiphum padi (L.) (Hemiptera: Aphididae)
Authors: Kong Fan-Bin , Cui Ling-Ling , Jiang Yu-Tai , Lv Yong-Po , Li Ren-Jie , Wang Yang , Li Xin-An , Zhang Bai-Zhong , Liu Run-Qiang 
Published: February 2025

Abstract
Rhopalosiphum padi is an important grain pest, causing severe losses during crop production. As a systemic insecticide, flonicamid can control piercing-sucking pests efficiently. In our study, the lethal effects of flonicamid on the biological traits of R. padi were investigated via a life table approach. Flonicamid is highly efficiently toxic to R. padi, with an LC50 of 9.068 mg L−1. The adult longevity and fecundity of the R. padi F0 generation were markedly reduced under the LC25 and LC50 concentrations of flonicamid exposure. In addition, negative transgenerational effects on R. padi were observed under exposure to lethal concentrations of flonicamid, with noticeable decreases in the reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation under the LC25 concentration of flonicamid. Furthermore, the third nymph stage (N3), preadult stage, duration of the adult pre-reproductive period, duration of the total pre-reproductive period, reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation were significantly lower under treatment with the LC50 concentration of flonicamid. The life table parameters were subsequently analysed, revealing that the intrinsic rate of increase (rm) and the net reproductive rate (R0) were significantly lower but that the finite rate of increase (λ) and the mean generation time (T) were not significantly different under the LC25 and LC50 concentrations of flonicamid. These data are beneficial for grain aphid control and are critical for exploring the role of flonicamid in the integrated management of this key pest.
The problem with the problem of mourning
Authors: Vicens Leigh 
Published: February 2025

Abstract
In her recent book The Image of God: The Problem of Evil and the Problem of Mourning (2022), Eleonore Stump takes up a question she thinks has been unduly neglected by contemporary philosophers of religion: Is the world as good as it would have been had original sin, and all subsequent sin and suffering, not occurred? Stump contends that if we do not answer this question in the affirmative, we are left with a problem – a picture of a world which is a disappointment to God; and this picture could in turn undermine belief in an omnipotent, omniscient, perfectly good Creator. In response to this problem, Stump sets out to defend the felix culpa view, according to which the world is even better with the Fall than it would have been without. However, I argue in this article that the felix culpa view has unacceptable consequences regarding God’s desires and will, that we can live with the problem of mourning unresolved, and that we need not affirm the felix culpa view to resolve the problem of mourning anyway.
Turner, Bird, Eratosthenes: An eternal burning thread
Authors: GIBBONS JEREMY 
Published: February 2025

Abstract
Functional programmers have many things for which to thank the late David Turner: design decisions he made in his languages SASL, KRC, and Miranda over the last 50 years are still influential and inspirational now. In particular, Turner was a strong advocate of lazy evaluation and of list comprehensions. As an illustration of these techniques, he popularized a one-line recursive “sieve” to generate the infinite list of prime numbers.
Turner called this algorithm The Sieve of Eratosthenes. In a lovely paper called “The Genuine Sieve of Eratosthenes”, Melissa O’Neill argued that Turner’s program is not in fact a faithful implementation of the algorithm, and gave a detailed presentation using priority queues of the real thing. She included a variation by Richard Bird, which uses only lists but makes clever use of circular programming. Bird describes his circular program again in his textbook “Thinking Functionally with Haskell”, and sets its proof of correctness as an exercise. In particular, why is this circular program productive? Unfortunately, Bird’s hint for a solution is incorrect. So what should a proof look like?
One of the last projects Turner worked on was the notion of “Total Functional Programming”. He observed that most programs are already structurally recursive or corecursive, therefore guaranteed respectively terminating or productive; he conjectured that “with more practice we will find this is always true”. We explore Bird’s circular Sieve of Eratosthenes as a challenge problem for Turner’s Total Functional Programming.
Understanding the Relationship Between South Pacific Oscillation and ENSO
Authors: Hu Suqiong , Zhang Wenjun , Jiang Feng 
Published: February 2025

AbstractThe boreal summer South Pacific Oscillation (SPO), the dominant mode of atmospheric variability over the South Pacific, has been proposed as a potential precursor to the development of El Niño‐Southern Oscillation (ENSO). However, this study demonstrates that the SPO signal during the developing summer of ENSO events is primarily driven by the concurrent ENSO‐related tropical Pacific sea surface temperature anomalies, challenging its role as an independent predictor of ENSO. We further show that those winter ENSO events preceded by a summer SPO signal begin to develop before the SPO signal in the extratropics appear, and incorporating the summer SPO signal into ENSO persitence model does not add additional information for ENSO hindcast. The observational findings are further corroborated by evidence that the lead relationship of SPO over ENSO in climate models is mainly determined by their simulated ENSO teleconnection to SPO during summer.
Seasonal Variations in the Strength of Sporadic Meteor Sources Observed by Meteor Radar
Authors: Luo Jiahui , Gong Yun , Zhang Shaodong , Zhou Qihou , Ma Zheng 
Published: February 2025

AbstractSporadic meteors are a significant source of metals in the Earth's atmosphere and ionosphere, and the understanding of the seasonal variations of their strengths can provide valuable insights into the origins and orbits of cosmic dust particles near Earth. This study analyzes meteor echo data collected by an all‐sky interferometric meteor radar in Ledong (LD, 18.4°N, 109.0°E) to quantify the strengths of sporadic meteor sources and their seasonal variations. The results indicate that the helion, antihelion, and apex sources are stronger than the north toroidal source, highlighting a concentration of sporadic meteors near the ecliptic plane and fewer near the ecliptic poles. Distinct seasonal variations are observed, with meteor activity peaking in April and September, likely corresponding to periods of increased meteor and dust particle density in Earth's orbit. Moreover, eight meteor showers are identified as significantly influencing the apparent radiant distributions and have comparable strengths with sporadic meteor sources. To enhance the analysis, a monthly radiant weighting system in ecliptic coordinates is developed, enabling precise calculation of source strengths and improved characterization of seasonal variations in radiant distributions. This research advances our understanding of sporadic meteors and their role in Earth's atmospheric processes, providing a foundation for future investigations into cosmic dust dynamics.
N-acetylcysteine for youth cannabis use disorder: randomized controlled trial main findings
Authors: Gray Kevin M. , Tomko Rachel L. , Baker Nathaniel L. , McClure Erin A. , McRae-Clark Aimee L. , Squeglia Lindsay M. 
Published: February 2025

Abstract
Cannabis use disorder is particularly prevalent and impairing among young people, and evidence-based treatments are limited. Prior trials of N-acetylcysteine, added to contingency management as a platform behavioral intervention, yielded positive findings in youth but not in adults. This trial sought to rigorously evaluate whether N-acetylcysteine is efficacious in youth when not paired with a robust behavioral treatment platform. Treatment-seeking youth with cannabis use disorder (N = 192, ages 14–21) were randomized to receive a double-blind 12-week course of oral N-acetylcysteine 1200 mg or placebo twice daily; all received weekly medical management and brief behavioral counseling. The primary efficacy outcome was the proportion of negative urine cannabinoid tests during treatment, compared between groups. An array of self-report and urine testing measures were examined secondarily to assess cannabis use reduction and cessation outcomes. The N-acetylcysteine and placebo groups did not differ in proportion of negative urine cannabinoid tests (RR = 0.93, 95% CI = 0.53, 1.64; p = 0.80) or self-reported cannabis abstinence (RR = 1.02, 95% CI = 0.63, 1.65; p = 0.93) during treatment. The mean percentage of cannabis use days and grams of cannabis used per using day decreased over time during treatment but did not differ between groups. More N-acetylcysteine than placebo treated participants reported gastrointestinal adverse events (63/98 versus 37/94, χ2
1 = 11.9 p < 0.001); adverse events were otherwise similar between groups. Findings indicate that N-acetylcysteine is not efficacious for youth cannabis use disorder when not paired with contingency management, highlighting the potentially crucial role of a robust behavioral treatment platform in facilitating prior positive efficacy findings with N-acetylcysteine.
Trial Registration: Clinicaltrials.gov identifier NCT03055377
Confirmation of successful supraglottic airway device placement in neonates using a respiratory function monitor
Authors: Dvorsky Robyn , Werther Tobias , Bibl Katharina , Schneider Michael , Binder Christoph , Habrina Lisa , Klebermaß-Schrehof Katrin , Kranebitter Veronika , Schmölzer Georg M. , Berger Angelika , Wagner Michael 
Published: February 2025

Abstract

Background
This study investigated the use of a respiratory function monitor (RFM) to guide the placement of a supraglottic airway device (SAD) in neonates during intensive care interventions. We hypothesized that using a RFM would decrease the number of attempts needed for a successful placement.

Methods
This single-center pilot study was carried out at a tertiary NICU at the Medical University of Vienna. Patients were ventilated using a SAD during neurosurgical or endoscopic interventions. A RFM was either hidden (but recording) or visible to providers during SAD placement. Feedback from the RFM was used to assess correct/incorrect placement and optimize ventilation quality. The parameter leakage was used for assessment: if leak was <30%, correct placement was assumed. The primary outcome was the number of attempts until correct placement. Secondary outcomes included ventilation parameters recorded by the RFM and the duration of SAD placement.

Results
Six patients were included in this pilot trial. Using a RFM to guide SAD placement led to fewer attempts (median attempts: 3 [hidden] vs. 1 [visible]). Furthermore, using the RFM, necessary adaptations were made to the SAD position to decrease leakage (mean leakage: 74.8% [hidden] vs. 17.8% [visible]), subsequently endoscopy after insertion of SAD using the RFM then confirmed anatomically correct position.

Conclusion
This pilot study indicated that a RFM might be useful to provide guidance during SAD placement.

Impact statement

Feedback from a RFM reliably indicated correct anatomical placement of a SAD by correlating low leakage values with proper SAD positioning.

RFM guidance could improve neonatal airway management, reducing procedural time and number of attempts.

We present promising preliminary results. Further research is needed to confirm these findings.
Urbanisation and mental health in left-behind children: systematic review and meta-analysis using resilience framework
Authors: Lin Kelly , Mak Leona , Cai Jinxuan , Jiang Stephen , Fayyaz Nawaal , Broadley Simon , Sun Jing 
Published: February 2025

Abstract

Background
Prolonged parental separation at young ages has significant adverse effects on development in left-behind-children (LBC). We aimed to compare mental health status, emotional and behavioural problems, and their association with socioemotional development between LBC and their counterparts.

Methods
Cross-sectional studies comparing LBC and non-LBC published from 2000 onwards were searched. Primary outcomes included depression, anxiety emotional and behavioural problems. Secondary outcomes included loneliness, self-harm, suicide, and risk-related behaviours. Quality of all included articles was assessed by Joanna Briggs Institute (JBI) critical appraisal. Data was analyzed by random model-based effect method.

Results
78 observational studies comprising of 394,308 children aged 2–18 were included. Compared to NLBC, LBC had significantly more depression, anxiety, emotional and behavioural problems, conduct problems, self-harm, loneliness, peer bullying, attempts of smoking and alcohol consumption. Subgroup analyses found that younger LBC between the ages of 6 to 12 were at greater risks of poor mental health, emotional and behavioural problems.

Conclusion
Absent parental care prevents healthy socio-emotional development and hinder the formation of secure attachment. Poor social-emotional development leads to worse emotional resilience against psychological stressors, while LBC residing in rural areas also experience additional risk factors of low household income and poor access to mental health services.

Impact statement

Prolonged parental separation negatively influences mental health, especially in younger children between the ages 6 to 12.

Poor social-emotional development in left-behind children is associated with worse emotional resilience against psychological stressors.

Additional risk factors including residing in rural areas, low household income, and poor access to mental health services predisposes left-behind children to high risks of mental illness.

Timely support services targeted towards strengthening resilience factor such as learning better emotional and behavioural coping strategies and improving school and peer support to address increased risk of mental health problems are required for current left-behind children.
Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease
Authors: He Yihuai , Jiang Jinlian , Ou Lili , Chen Yunfen , Abudukeremu Aikedaimu , Chen Guimei , Zhong Weiwei , Jiang Zhigang , Nuermaimaiti Nuerbiye , Guan Yaqun 
Published: February 2025

Abstract
RelA, also known as nuclear factor kappa B p65, plays a crucial role in the pathogenesis of various liver diseases. However, the specific role of RelA in hepatocytes during the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) is not well understood. This study explored the relationship between impaired RelA signaling and lipid metabolism disorders in hepatocytes, and how they synergistically contribute to the advancement of MASLD. We assessed the changes, regulatory relationships, and impacts of RelA signaling and lipid metabolism remodeling on disease progression both in vitro and in vivo. During MASLD, there was a decrease in the expression of RelA and hepatocyte nuclear factor 1 alpha (HNF1α), with both factors showing mutual enhancement of each other’s expression under normal conditions. This synergistic effect was absent during hepatocyte steatosis. RelA or HNF1α depletion in hepatocytes intensified MASLD symptoms, whereas overexpression of RELA or treatment with necrostatin-1 (a necroptosis inhibitor) or Z-VAD (a caspase inhibitor) significantly mitigated these effects. Mechanistically, during hepatic steatosis, altered lipid profiles exhibited lipotoxicity, inducing hepatocyte apoptosis and necroptosis, whereas endoplasmic reticulum (ER) stress triggered lipid remodeling processes similar to those observed in MASLD. RelA signaling upregulated the expression of activating transcription factor 4 and glucose-regulated protein 78, thereby alleviating ER stress. Impaired RelA signaling remodeled the ER stress response and lipid metabolism, and enhanced lipid accumulation and lipid toxicity. In conclusion, impaired RelA signaling and disrupted lipid metabolism form a detrimental feedback loop in hepatocytes that promotes MASLD progression. Lipid accumulation suppresses RelA signaling, remodeling the ER stress response and exacerbating lipid metabolism disorder, ultimately leading to hepatocyte apoptosis and necroptosis.
Peroxisome proliferator-activated receptor alpha is an essential factor in enhanced macrophage immune function induced by angiotensin-converting enzyme
Authors: Saito Suguru , Cao Duo-Yao , Bernstein Ellen A. , Shibata Tomohiro , Jones Anthony E. , Rios Amy , Hoshi Aoi O. , Stotland Aleksandr B. , Nishi Erika E. , Van Eyk Jennifer E. , Divakaruni Ajit , Khan Zakir , Bernstein Kenneth E. 
Published: February 2025

Abstract
Increased expression of angiotensin-converting enzyme (ACE) by myeloid lineage cells strongly increases the immune activity of these cells, as observed in ACE10/10 mice, which exhibit a marked increase in antitumor and antibactericidal immunity. We report that peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor that regulates genes critical for lipid metabolism, is a key molecule in the enhanced macrophage function induced by ACE. Here, we used a Cre–LoxP approach with LysM-Cre to create a modified ACE10/10 mouse line in which macrophages continue to generate abundant ACE but in which monocyte and macrophage PPARα expression is selectively suppressed. These mice, termed A10-PPARα-Cre, have significantly increased growth of B16-F10 tumors compared with ACE10/10 mice with Cre expression. PPARα depletion impaired cytokine production and antigen-presenting activity in ACE-expressing macrophages, resulting in reduced tumor antigen-specific CD8+ T-cell generation. Additionally, the elevated bactericidal resistance typical of ACE10/10 mice was significantly reduced in A10-PPARα-Cre mice, such that these mice resembled WT mice in their resistance to methicillin-resistant Staphylococcus aureus (MRSA) infection. THP-1 cells expressing increased ACE (termed THP-1-ACE) constitute a human macrophage model with increased PPARα that shows enhanced cytotoxicity against tumor cells and better phagocytosis and killing of MRSA. RNA silencing of PPARα in THP-1-ACE cells reduced both tumor cell death and bacterial phagocytosis and clearance. In contrast, the in vivo administration of pemafibrate, a specific agonist of PPARα, to WT and A10-PPARα-Cre mice reduced B16-F10 tumor growth by 24.5% and 25.8%, respectively, but pemafibrate reduced tumors by 57.8% in ACE10/10 mice. With pemafibrate, the number of antitumor CD8+ T cells was significantly lower in A10-PPARα-Cre mice than in ACE10/10 mice. We conclude that PPARα is important in the immune system of myeloid cells, including wild-type cells, and that its increased expression by ACE-expressing macrophages in ACE10/10 mice is indispensable for ACE-dependent functional upregulation of macrophages in both mice and human cells.