bluuebunny/crossref_metadata_2025_split huggingface dataset:
A national assessment of standards of care for inherited bleeding disorders in Canada
Authors: Page David , Crymble Sarah , Jardine Lawrence , Nilson JoAnn , Mulder Kathy , Pardy Natasha , Pirnat Bojan , Pirnat Milena , Quinn Wendy , Sims Karen , Thompson Marie‐Hélène , Wilton Pam 
Published: September 2023

AbstractAimThe Canadian Integrated and Comprehensive Care Standards for Inherited Bleeding Disorders were adopted in June 2020. In early 2023, a self‐assessment of each of the 26 Canadian inherited bleeding disorder treatment centre's (IBDTCs) capacity to meet the Standards was conducted. The goal was to validate the standards by assessing appropriateness and adherence. As a result, centres can compare their own practices and capacity against those of all centres, identify barriers to adherence, identify opportunities for remedial actions and use the results locally as evidence for needed resources.MethodsHealthcare providers (HCPs) in the 26 IBDTCs were provided with a checklist to assess adherence to each of the 66 standards of care. Centre participation was voluntary but strongly encouraged by the healthcare provider and patient associations.ResultsAll 26 centres completed the self‐assessments. Collectively, centres reported meeting 88.8% of the standards. Adherence to each standard ranged from 40% to 100%. Forty‐one (41) of the standards were adhered to by 90% or more of the centres, 12 by 80%–89% of the centres and 13 by fewer than 80% of the centres. A report consolidating all the assessments was sent to the 26 centres.ConclusionNone of the comments received in the self‐assessment reports indicated that a given standard was irrelevant, unrealistic or unnecessary. These data are strong indicators that the standards, as written, are appropriate. The self‐assessments, however, reveal alarming deficiencies in staffing levels, notably in physiotherapy, psychosocial support and data entry and data management. These constitute a barrier to comprehensive care for many centres. The findings echo similar conclusions from a previous assessment conducted in 2015.
Oropharyngolaryngeal manifestations in severe toxic epidermal necrolysis: a single‐center's retrospective case series
Authors: Glasson Nicolas , De Sandre Cécile , Pantet Olivier , Reinhard Antoine , Lambercy Karma , Sandu Kishore , Gorostidi François 
Published: September 2023

AbstractBackgroundToxic epidermal necrolysis is a rare and life‐threatening mucocutaneous disease. Although mucosal ear, nose, and throat (ENT) involvement is common, little is known about the characteristics, treatment modalities, and outcomes of these lesions. The aim of this study was to evaluate ENT mucosal lesions in severe toxic epidermal necrolysis patients and analyze their characteristics, treatment modalities, and outcomes, as well as proposing a management algorithm to prevent long‐term debilitating sequalae of these lesions.MethodsThis is a retrospective review of toxic epidermal necrolysis cases treated at the tertiary burns unit of the Lausanne University Hospital CHUV, Switzerland, between 2006 and 2019.ResultsOut of 19 patients with severe toxic epidermal necrolysis, 17 (89%) underwent a complete ENT examination at admission and 14 (82%) had ENT mucosal involvement. Five (26.3%) patients died during the stay in the intensive care unit. Of the 16 patients who received maximal care, 13 (81%) required orotracheal intubation for a median time of 16 (IQR: 14) days. Out of the 14 patients who survived, four (29%) had long‐term ENT complications consisting of synechiaes necessitating subsequent endoscopic procedures. Those four patients all required mechanical ventilation with an orotracheal tube and suffered from hypopharyngeal synechiaes as well as oral and endonasal synechiaes in individual cases.ConclusionThis study suggests a high prevalence of ENT synechiaes in patients with severe toxic epidermal necrolysis and requiring orotracheal intubation. Periodic ENT examination could prevent mature synechiae formation in these patients. We propose an algorithm to prevent long‐term sequalae in ENT mucosal involvement.
Clinicopathological characteristics of fibrosing alopecia in a pattern distribution: a single‐center, retrospective study
Authors: Wei Kelu , Ni Chunya , Huang Qiong , Yang Kai , Zhang Yue , Liu Qingmei , Sha Yuou , Zhang Qiaoan , Lin Jinran , Wu Wenyu 
Published: September 2023

AbstractBackgroundFibrosing alopecia in a pattern distribution (FAPD) is a distinct entity of primary cicatricial alopecia (PCA), mimicking diffuse hair loss of androgenetic alopecia (AGA) with trichoscopic and histopathologic features of both AGA and lichen planopilaris (LPP).MethodsClinical, demographic, and histopathological data of 20 FAPD patients were retrospectively collected.ResultsAll patients presented with female pattern hair loss with a median Sinclair grade of 3. Trichoscopic findings revealed hair diameter variability (20/20), perifollicular erythema (mild 7/20, moderate 11/20, severe 2/20), peripilar casts (none 2/20, mild 12/20, moderate 5/20, severe 1/20), and loss of follicular ostia (+12/20, ±7/20, −1/20). Histopathologic examination revealed perifollicular lymphocytic infiltration at the infundibulum or isthmus level and an increase of vellus‐like hairs. All cases showed interface dermatitis with concentric perifollicular lamellar fibrosis and follicular scars. Infundibular or isthmic infiltration of mast cells was found.ConclusionsThe uniqueness of our study lies in perifollicular mast cells and discovering that the young population is at higher risk than previously thought. Clinicopathological features of FAPD were identified, filling the void of much‐needed details for FAPD diagnosis tailored to the Chinese population.
Do supplementary jobs for welfare recipients increase the chance of welfare exit? Evidence from Germany
Authors: Mosthaf Alexander , Schank Thorsten , Schwarz Stefan 
Published: September 2023

AbstractWelfare recipients in Germany are allowed to take up supplementary jobs while receiving welfare. In the present study, we use the German Panel Study “Labour Market and Social Security” (PASS) for the years 2006–2014 to analyze the impact of these supplementary jobs on the chances of welfare exit. Dynamic multinomial logit models controlling for unobserved heterogeneity and endogenous initial conditions reveal that full‐time employed men and women are more likely to exit welfare into employment than their non‐employed counterparts. For supplementary part‐time jobs, however, we find no or (only in some specifications for men) much smaller stepping stone effects.
Study of platelet‐rich fibrin combined with rat periodontal ligament stem cells in periodontal tissue regeneration
Authors: Duan Xuejing , Lin Zhiyong , Lin Xiujuan , Wang Zhiqiang , Wu Yihua , Ji Mei , Lu Wei , Wang Xiaoyang , Zhang Dongsheng 
Published: September 2023

AbstractThe objective of this study was to investigate the advantages and feasibility of periodontal tissue regeneration using platelet‐rich fibrin (PRF) combined with rat periodontal ligament stem cells (PDLSCs) for the first time. We first determined the effect of PRF on rat PDLSCs in vitro. We next conducted an in vivo study, in which a tissue engineering technique was performed to repair periodontal defects in five groups: a blank group, collagen group (implanted collagen membrane), collagen + cells group (implanted collagen membrane and rat PDLSCs), PRF group (implanted PRF membrane) and PRF + cells group (implanted PRF membrane and rat PDLSCs). PRF greatly enhanced cell proliferation, mRNA and protein expression levels of bone sialoprotein (BSP), osteocalcin (OC), and runt‐related transcription factor 2 (RUNX2) and activity of alkaline phosphatase (ALP) in vitro. Transplantation of PRF combined with rat PDLSCs resulted in higher expression of osteopontin (Opn), collagen I (COL1A) and RUNX2 at both 12 and 24 days after surgery. Micro‐computed tomography and histological analysis showed substantially more new bone formation in the PRF + cells group at 24 days after surgery. Based on these results, we discuss the role of PRF in the proliferation and differentiation of rat PDLSCs and suggest that PRF combined with rat PDLSCs provides a valuable tool for periodontal tissue engineering.
The role of reflectance confocal microscopy in the diagnosis and management of pigmentary disorders: A review
Authors: Farabi Banu , Khan Samavia , Jamgochian Marielle , Atak Mehmet Fatih , Jain Manu , Rao Babar K. 
Published: September 2023

AbstractBackgroundReflectance confocal microscopy (RCM) has quickly transitioned from a research tool to an adjunct diagnostic bedside tool, providing the opportunity for noninvasive evaluation of skin lesions with histologic resolution. RCM is an optical imaging technique that uses near‐infrared excitation wavelengths and safe low‐power lasers. En‐face images of different skin layers (up to the superficial dermis) are acquired in grayscale based on the reflective indices of tissue components. Melanin has the highest reflective index (contrast) and appears bright on RCM.AimsWe present a review of the current literature on the use of RCM in the diagnosis and management of pigmentary disorders.MethodsWe reviewed PubMed and Ovid Medline databases from January 2000 to June 2021, using MeSH key terms: “reflectance confocal microscopy, confocal laser scanning microscopy, pigmentary disorders, treatment, melasma, vitiligo, freckles, solar lentigo, lentigo, tattoo, complications, melanoma, skin cancers, pigmented lesions, post inflammatory, melanin, photoaging” to identify studies and review articles discussing the use of RCM in the diagnosis and management of pigmentary disorders.ResultsRCM findings of pigmentary disorders were divided into the following categories: (1) disorders of increased pigmentation (post‐inflammatory hyperpigmentation, melasma, Riehl's melanosis, solar lentigines, ephelides, hori nevus, naevus of Ota, café‐au‐lait macules, melanocytic nevus, melanoma, nevus spilus, labial mucosal melanosis, and mucosal melanoma), (2) disorders of decreased pigmentation or depigmentation (post‐inflammatory hypopigmentation, vitiligo, nevus depigmentosus, halo nevus), and (3) exogenous pigmentation (tattoo, ochronosis).ConclusionRCM has been explored and proven valuable for the evaluation and management of pigmentary disorders including melasma, vitiligo, solar lentigines, tattoo, and tattoo‐related complications.
Recreational cannabis policy reform—What mental health nurses need to know about minimising harm and contributing to the reform debate
Authors: Murta Janina Catalao Dionisio , Easpaig Brona Nic Giolla , Hazell‐Raine Karen , Byrne Mitchell K. , Lertwatthanawilat Wanchai , Kritkitrat Preeyakamon , Bressington Daniel 
Published: September 2023

AbstractThe recently rapidly evolving legal status of recreational cannabis in various countries has triggered international debate, particularly around measures required to minimise resulting harms. The present article argues that mental health nurses should have a key role in promoting safe and appropriate use of recreational cannabis, and minimising harm based on the extant evidence. The article summarises the factors driving legalisation, outlines the evident medicinal benefits of cannabis, and appraises the evidence on the negative mental health impacts associated with use. We go on to discuss research findings on the potentially deleterious mental health effects resulting from legalising recreational cannabis and strategies to minimise these harms, including directions for future research and evaluation. Further, we consider the importance of the implementation of harm minimisation measures that are context‐specific, using Thailand as an example. Finally, we present the key health promotion messages that mental health nurses should aim to convey to people who use or consider using recreational cannabis. Ultimately, we aim to provide a summary of the existing evidence that mental health nurses can draw upon to promote mental health and engage with the policy reform debate.
Extracellular vesicles biogenesis and uptake concepts: A comprehensive guide to studying host–pathogen communication
Authors: Sabatke Bruna , Rossi Izadora Volpato , Sana Abel , Bonato Leticia Bassani , Ramirez Marcel I. 
Published: September 2023

AbstractThe study of host–pathogen interactions has increased considerably in recent decades. This intercellular communication has been mediated by extracellular vesicles (EVs) that play an important role during the interaction. EVs are particles of lipid bilayer and described in different types of cells, eukaryotic or prokaryotic. Depending on their biogenesis they are described as exosomes (derived from multivesicular bodies) and microvesicles (derived from the plasma membrane). The EVs carry biomolecules, including nucleic acids, lipids, and proteins that can be released or internalized by other cells in different pathways (endocytosis, macropinocytosis, phagocytosis, or membrane fusion) in the process described as uptake. The balance between biogenesis and uptake of EVs could modify physiological and pathophysiological processes of the cell. This review is focusing on the dynamic roles of release and capture of EVs during host–pathogen interaction. We also do a critical analysis of methodologies for obtaining and analyzing EVs. Finally, we draw attention to critical points to be considered in EV biogenesis and uptake studies.
Food and non‐alcoholic beverage marketing in children and adults: A systematic review and activation likelihood estimation meta‐analysis of functional magnetic resonance imaging studies
Authors: Boyland Emma , Maden Michelle , Coates Anna E. , Masterson Travis D. , Alblas Monique C. , Bruce Amanda S. , Roberts Carl A. 
Published: September 2023

SummaryFood marketing impacts the food behaviors of children and adults, but the underpinning neural mechanisms are poorly understood. This systematic review and meta‐analysis pooled evidence from neuroimaging studies of exposure to food marketing stimuli (vs. control) on brain activations in children and adults to clarify regions associated with responding. Databases were searched for articles published to March 2022. Inclusion criteria included human functional magnetic resonance imaging (fMRI) studies employing a contrast between a food marketing stimulus and a non‐food/non‐exposure control, published in English in a peer‐reviewed journal, reporting whole brain (not Region of Interest [ROI] only) co‐ordinates. Eleven studies met inclusion criteria, of which eight were included in the quantitative synthesis (Activation Likelihood Estimation [ALE] meta‐analysis). Food marketing exposures (vs. controls) produced greater activation in two clusters lying across the middle occipital gyrus, lingual gyrus, and cuneus (cluster 1), and the postcentral gyrus, precentral gyrus, and the inferior parietal lobule/supramarginal gyrus (cluster 2). Brain responses to food marketing are most consistently observed in areas relating to visual processing, attention, sensorimotor activity, and emotional processing. Subgroup analyses (e.g., adults vs. children) were not possible because of the paucity of data, and sensitivity analyses highlighted some instability in the clusters; therefore, conclusions remain tentative pending further research.
Scoping review of outcome measures in cleft care used in research and reports
Authors: Sarilita Erli , Sjamsudin Endang , Mossey Peter A. 
Published: September 2023

AbstractTreatment outcome measures are critical in the decision making of best practices in the OFC field. OFC consortium working groups provided standardization of outcome measures based on previous treatment outcome studies. However, the implementation of such standardization in OFC centres worldwide is unknown. This study presented mapped outcome measures in cleft care using a structured review method complemented by quantitative overview of the relevant published research to provide initial guidelines for the implementation of treatment outcome standardization. A scoping review of the literature of treatment outcomes in cleft care following Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Reviews guidelines was performed. The selected indexed paper in outcome measures mapped following the international consortium in standard set of outcome measures in cleft care. Three hundred and sixty‐five articles were filtered. The most discussed domains of cleft care were dental and oral health, appearance and speech/communication. Overall, the majority of publications were produced in high‐income countries. The current review indicates that there are inequalities of treatment outcome studies among the domain of cleft care. In addition, there are also inequalities of published articles from HIC versus LMIC in treatment outcomes. This information can be used to develop targeted interventions aimed at encouraging cleft centres worldwide to adapt standardized outcome measures.
Impact of the COVID‐19 pandemic on sleep bruxism among adolescents in Brazil: A longitudinal study
Authors: Lito Marcia Farias Pereira , Knorst Jessica Klöckner , Noronha Thaís Gioda , Pohl Marina Blanco , Brondani Bruna , de Araújo Gabriela , Ardenghi Thiago Machado , Tomazoni Fernanda 
Published: September 2023

AbstractAimTo evaluate the immediate and late impact of the COVID‐19 pandemic on the occurrence of possible sleep bruxism (SB) among adolescents in Brazil.DesignThis is a longitudinal study performed with adolescents (11–15 years old) from Southern Brazil. Baseline data were collected before the Brazilian COVID‐19 outbreak (T1). Posteriorly, data were collected after 3 (T2) and 15 months under the Brazilian COVID‐19 outbreak. The possible SB was evaluated by the question: ‘Do you grind your teeth during your sleep?’. Sociodemographic, psychosocial and clinical variables were also collected. Changes in SB were evaluated by multilevel logistic regression models for repeated measures.ResultsOf the 290 adolescents assessed at T1, 182 were reassessed at both follow‐ups. The prevalence of possible SB was 13% at T1, 11% at T2 and 22% at T3. There were no immediate effects of the COVID‐19 pandemic on the occurrence of possible SB (T2). Adolescents had odds 2.77 times greater of presented possible SB after 15 months (T3) of COVID‐19 pandemic scenarios when compared to T1.ConclusionThere was a considerable and late increase in the possible SB in adolescents in Brazil during the COVID‐19 pandemic.
Gender inequality among the editorial boards of periodontology and implantology journals
Authors: Pekin Sevgi , Buduneli Nurcan , Ellidokuz Hülya , Akcalı Aliye 
Published: September 2023

AbstractObjectivesThe aim of the present study was to investigate gender composition of the editorial board members of the journals in the field of periodontology and implantology.Materials and MethodsA rigorous search was performed through Web of Science database to identify journals, scoping on the periodontology and implantology research fields. Data on journal's demographic information, gender of the editorial board members were gathered from the journals fulfilling the predefined inclusion/exclusion criteria. Variables including journal impact factor and quartiles were extracted as well.ResultsThe proportion of women in the editorial team in periodontology journals was 27.3%, whereas it was almost 19% in implantology journals. As for editorial leadership, these ratios were 22.1% and 19.8%, respectively. There were significantly less women than men in editor‐in‐chief position in periodontology journals (p = 0.042). Journal metrics had no impact on the gender distribution of editor‐in‐chief positions in both fields.ConclusionsWomen seem to be under‐represented as editorial leaders or board members in journals of periodontology and implantology. The proportion of women in periodontology journals has increased in the last decade; however, there is still a clear need for further increase to have a gender balance.
One Step Double Augmentation with Human Dermis Allograft and Homologous PRP in Misdiagnosed and or Chronic Achilles Tendon Ruptures
Authors: Lughi Marcello , Bondioli Elena , Moretti Cinzia , Maitan Nicolò , Ferretti Matteo , Casadei Roberto 
Published: September 2023

ObjectiveMisdiagnosed/chronic Achilles tendon injuries are rare and disabling for patients. The surgical treatment of these rare injuries aims to ensure the tendon heals mechanically and biologically. This is the prerequisite for a good clinical and functional outcome and reduces recurrences. The main aim of the study is to present a surgical technique that has proven to be original, reproducible, and capable of guaranteeing solid tendon repair and optimal tissue regeneration.MethodsWe treated five patients, four males and one female, with the one‐step double augmentation technique. All patients of this study complained of pain, but above all severe functional limitation that Achilles tendon injury had been causing for more than a month. In this study, we widely described the surgical technique, original and not found in the literature, which provides a biological graft (allograft of decellularized dermis) and homologous, thrombin‐activated, platelet‐rich plasma (H‐PRP) in a single step. Surgical approach, always used by the first author, respected predefined steps: careful dissection and preparation of the peritendinous tissues from suture to the end of the procedure, tenorrhaphy, and augmentation with allopatch to obtain a mechanically effective repair to avoid recurrences, and finally “biological” augmentation with a unit of homologous, thrombin activated, PRP. We offered to all patients a regenerative rehabilitation program post‐operatively.ResultsAll patients were evaluated clinically (functional clinical tests and questionnaires) and instrumentally (elastic‐sonography and perfusion MRI). The obtained results have been evaluated at a minimum follow‐up of 18 months and a maximum of 24 months. In all patients pain was resolved, and district function and kinetic chains improved with resumption of daily activities, work, and sports.ConclusionThe present study confirmed the regenerative potential of decellularized dermis allograft and PRP (homologous and thrombin‐activated). The same approach can also be exploited in cases of severe tendon destructuring and limited “intrinsic” regenerative potential at any age. The proposed one‐step surgical technique of a double augmentation therefore appears useful, safe, reproducible, and applicable in all chronic tendon lesions with low regenerative potential.