bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination
Authors: Tong Xin , Deng Yixiang , Cizmeci Deniz , Fontana Laura , Carlock Michael A , Hanley Hannah B , McNamara Ryan P , Lingwood Daniel , Ross Ted M , Alter Galit 
Published: November 2023

Abstract
Influenza viruses infect 5–30% of the world’s population annually, resulting in millions of incidents of hospitalization and thousands of mortalities worldwide every year. Although annual vaccination has significantly reduced hospitalization rates in vulnerable populations, the current vaccines are estimated to offer a wide range of protection from 10 to 60% annually. Such incomplete immunity may be related to both poor antigenic coverage of circulating strains, as well as to the insufficient induction of protective immunity. Beyond the role of hemagglutinin (HA) and neuraminidase (NA), vaccine-induced Abs have the capacity to induce a broader array of Ab effector functions, including Ab-dependent cellular cytotoxicity, that has been implicated in universal immunity against influenza viruses. However, whether different vaccine platforms can induce functional humoral immunity in a distinct manner remains incompletely defined. In this study, we compared vaccine-induced humoral immune responses induced by two seasonal influenza vaccines in Homo sapiens, the i.m. inactivated vaccine (IIV/Fluzone) and the live attenuated mucosal vaccine (LAIV/FluMist). Whereas the inactivated influenza vaccine induced superior Ab titers and FcγR binding capacity to diverse HA and NA Ags, the live attenuated influenza mucosal vaccine induced a more robust functional humoral immune response against both the HA and NA domains. Multivariate Ab analysis further highlighted the significantly different overall functional humoral immune profiles induced by the two vaccines, marked by differences in IgG titers, FcR binding, and both NK cell–recruiting and opsonophagocytic Ab functions. These results highlight the striking differences in Ab Fc-effector profiles induced systemically by two distinct influenza vaccine platforms.
An In Vivo Evaluation of Postoperative Pain after Root Canal Instrumentation Using Manual K-files and Kedo-S Rotary files in Primary Molars
Authors: Bohidar Subhajit , Goswami Poulami , Arya Ashtha , Singh Sumit , Samir P V , Bhargava Triveni 
Published: November 2023

ABSTRACT

Aim:
To determine postoperative pain after root canal instrumentation using manual K-file and rotary Kedo-S files in primary molars.

Material and Method:
Thirty-six primary mandibular molars from 4- to 8-year-old children requiring pulpectomy were randomly split into two groups of 18 teeth each, that is, manual file K-file (Group I) and Kedo-S rotary file (Group II). Children’s pre- and postoperative pain was assessed using a four-point scale at different time intervals.

Results:
From the result of the present study, it was observed that the Kedo-S group showed significantly less pain after 24, 48, and 72 h.

Conclusion:
It was concluded from the present research that patients enrolled in the Kedo-s group experienced less pain.
Comparative Evaluation of Cutting Efficiency of Three File Systems—Kedo-SH Manual, Pedoflex Rotary, and Manual K File: An In Vitro Study
Authors: Kesri Rituraj , Pardhi Nikita , Surana Pratik , Ukey Ankita , Agrawal Pankaj K. , Agrawal Sonam 
Published: November 2023

ABSTRACT

Aims:
The purpose of this study was to comparatively evaluate the cutting efficiency of Pedoflex rotary, Kedo SH manual file, and manual K file systems used in root canal instrumentation while performing pulp therapy of deciduous teeth with a stereomicroscope.

Materials and Methods:
Forty-five extracted primary human root canals were chosen, and following the removal of pulp tissue, the canals were dyed with Indian ink and left to dry for 2 h. The samples were randomly divided into three groups, Group A: Kedo SH manual file system (n = 15), Group B: Pedoflex rotary file system (n = 15), and Group C: Manual K files (n = 15). After root canal instrumentation, all the root canals were cleared to make them transparent. The teeth after clearing were observed under stereomicroscope and scored according to the amount of dye present in the root canals. The data were tabulated and statistically analyzed with SPSS version 16 using Chi-square, Kruskal–Wallis, and Dunn’s test (post-hoc).

Results:
With regards to cutting efficiency, there was a statistically noteworthy difference among groups A and C [P = 0.000] and groups B and C [P = 0.000]. Furthermore, groups A and B did not differ statistically significantly [P = 0.950].

Conclusions:
Cutting efficacy of the Pedoflex rotary files was seen to be superior to that of Kedo SH and manual K files.

Clinical Significance:
Rotary files in deciduous teeth have various benefits over manual files, resulting in a noticeable reduction in working time, which has aided in maintaining patient participation by reducing the risk for fatigue. We conclude that NiTi rotary devices result in a superior cutting efficiency and, as a result, greater clinical success.
Frontier Orientalism in D.A. Milyutin's Descriptions of the North Caucasus in the 1840s
Authors: Tkachenko Dmitry S. 
Published: November 2023

The article delves into the analysis of Orientalist conceptions put forth by the Russian military scholar, D. A. Milyutin, in his narrative about the peoples of the North Caucasus. This study is anchored in “postcolonial critiques”, a lens extensively applied by international researchers to evaluate the actions of European powers in global peripheries. The aim of this research is to introduce the hitherto overlooked unpublished manuscripts of D. A. Milyutin into academic discourse. Specifically, this focuses on his descriptions of Kabarda and Chechnya, which form the foundation for analyzing the scholarly issue discussed.
The paper reveals that, when describing local populations, Russian military scholars actively leaned on Orientalist conceptions. They not only furnished those conceptions with empirical data but also interpreted them in context of the realities faced on the Russo-Caucasian frontier. Assertions that juxtapose Europe with the East, the interplay between the scholarly study of the region and its governance structure, and notions about the inherent stagnation of Eastern societies, as well as the belief in the necessity of external control for the development of Eastern communities, are all echoed in D. A. Milyutin’s works. Concurrently, his rendition of pan-European thoughts introduces a unique “frontier Orientalism”. This perspective captures descriptions of the militarized lifestyle of local residents, their raiding habits along the Line, and provides reasoning for the extended duration of Russian military engagements in the ethnic territories of the Caucasus.
This article is tailored for a diverse range of scholars, as well as anyone with a keen interest in the intellectual history of the Caucasus and the evolution of socio-political thought in the mid-19th century Russian Empire.
The School System of the Transcaspian Region in the 1890s‑1910s as a Reflection of Imperial Unification Policy
Authors: Besherov Pena , Zhukovskaya Tatiana N. 
Published: November 2023

The article delves into the historical examination of Russian and Russian-Native elementary schools within the Trans-Caspian region, an autonomous territory under the dominion of the Russian Empire, which over the course of three decades of imperial rule, transformed into a cultural frontier. Given the economic advancement of this region characterized by military-administrative governance, the school emerged as a significant socio-cultural institution, serving as a pivotal conduit for the dissemination of Russian influence throughout the area. Concurrently, it functioned as a platform for imperial social and cultural assimilation. While by the conclusion of the imperial era, this process had not yet yielded in substantial transformations within the local society due to the limited number of educational institutions and students, it nonetheless laid the foundation for a model of educational administration that functioned as a tool of imperial influence.
The study draws upon both published and archival documents to provide a comprehensive overview of all the elementary Russian-Turkic schools that operated within the Trans-Caspian region, encompassing relatively understudied Russian-Tatar and Russian-Persian schools as well. The article identifies a range of salient characteristics inherent to Russian-Turkic schools. It expounds upon the daily routines of these institutions, their curricula, pedagogical methods, teacher status, and related data. Through an exploration of the organization and activities of all Russian-Turkmen schools within the region, the analysis reveals that the most distinguished among them served as platforms for fostering ethno-cultural interactions and subsequently contributed to the emergence of a novel Turkmen elite.
The Russian Frontier in the North Caucasus: Issues of Periodization
Authors: Magaramov Sharafutdin A. 
Published: November 2023

The article addresses the challenge of periodizing the Russian frontier in the North Caucasus by establishing chronological boundaries and characterizing the major stages of the region's frontier history evolution. The periodization of the Caucasus frontier is rooted in the unique dynamics and nuances of ethnocultural interactions between the North Caucasus and the Muscovite state/Russian Empire, as well as the transformation of different frontier elements. Although the periodization of the North Caucasian frontier introduced in this article is a novel contribution to academic literature, scholars have tackled the issue of periodizing the Russian frontier in the North Caucasus before. The author's conceptual framework identifies four distinct stages in the history of the Caucasus frontier, each with its specific label: the “Terek” phase (second half of the 16th century – 1721), the “Persian” phase (1722–1735), the “Kizlyar-Mozdok” phase (1735–1817), and the “Caucasian War” period (1817–1864). Throughout each stage, Russian boundaries advanced further into the region, and at times, Russia was compelled to cede territories it had recently annexed. Following the end of the Caucasian War, the North Caucasian frontier reached its terminus, leading to the region's integration into the political and legal framework of the Russian Empire. Assertions by some scholars that the North Caucasus remains an “eternal frontier” and that its frontier phase never truly concluded are at odds with historical facts. Over the past 150 years, there's no evidence pointing to the North Caucasus fulfilling the generally recognized criteria of a frontier zone.
The Specifics of the Functioning of Lübeck Law in Narva within the Context of Hanseatic Trade in the 15th to the First Half of the 16th Century
Authors: Yakunina Valentina A. 
Published: November 2023

Medieval Narva was the easternmost city of Livonia, falling within the purview of Lübeck law. Due to a range of political and economic factors, Narva’s legal system experienced dynamic transformations throughout the 15th and the first half of the 16th centuries. Alongside the Lübeck code, norms of customary, seigniorial, and merchant law were in effect. This study delves into the evolution of Lübeck law and the city’s judicial system in the context of legal pluralism and is contextualized within the broader framework of Russian-Hanseatic trade. The research suggests that Narva’s legal system was tailored primarily to serve the economic and political interests of the city’s leadership. Lübeck law, serving as the official regulatory system for its citizens, seamlessly incorporated foreign elements, which, over time, were perceived as integral. Lübeck’s political and economic approaches towards Narva in the late 15th and early 16th centuries left a mark on several developmental facets of the city. From the last quarter of the 15th century onwards, Narva had the recourse to appeal to Lübeck as its supreme judicial authority, even though Revel initially held this position. A detailed examination of the city’s evolving legal structures, influenced by trade and political dynamics, will likely intrigue historians focused on the Baltic region as well as those specialized in legal history.
Relato de experiência de vivências práticas em instituições de longa permanência para idosos (ILPI) com jogos cognitivos
Authors: Bonotto Mariana , Rangel de Oliveira Sandra 
Published: November 2023

Este trabalho é um compilado das vivências práticas realizadas pelos alunos do 5º Semestre noturno do curso de enfermagem da Faculdade Cleber Leite, na disciplina Saúde do Idoso com o objetivo de levar os alunos a buscarem referencial teórico que os ajudassem a selecionar jogos de raciocínio para atividades com os idosos em situação de abrigo, analisando os resultados e comparando com o referencial teórico por eles estudado. Trabalhos como esses, objetivam uma formação mais humanizada dos profissionais da saúde através da vivência prática e reflexão das ações desses futuros enfermeiros em intervenções em diversos contextos.
Cuidados com idosos. Recriação Geriátrica. Enriquecimento Cognitivo. Aprendizado do Enfermeiro
STRATEGI PENINGKATAN DAYA SAING PERAJIN LONTONG DI ERA INDUSTRI 4.0 (Studi Kasus Kampung Lontong Banyu Urip Lor di Kota Surabaya)
Authors: Agung Bayu Murti  , Erma Tri Wahyuningdyah  
Published: November 2023

Tujuan umum penelitian ini adalah adanya strategi dan kebijakan yang tepat sasaran terkait upaya peningkatan daya saing agar pengrajin lontong khususnya UMK Kampung Lontong di Kupang Krajan Surabaya mampu berdaya saing dan masuk dalam supply chain industri kuliner Kota Surabaya sehingga meningkatkan pertumbuhan ekonomi di Kota Surabaya. Dalam penelitian ini digunakan pendekatan Aset-Proses-Kinerja (Asset-Process-Performance) atau lebih dikenal dengan sebutan Pendekatan APP sebagai basis penyusunan kerangka konseptual. Pendekatan APP muncul sebagai gagasan yang mengintegrasikan berbagai sumber daya yang kemudian mengalami proses dan selanjutnya menghasilkan kinerja sebagai suatu kesatuan ukuran daya saing (Momaya, 1998; Shee, 2002). Metode Penelitian yang digunakan adalah penelitian deskriptif dengan menggunakan survey. Penelitian deskriptif dapat diartikan sebagai proses pemecahan masalah yang diselidiki dengan melukiskan keadaan subyek dan obyek penelitian pada saat sekarang berdasarkan fakta-fakta yang tampak atau bagaimana adanya. Populasi dalam penelitian ini adalah seluruh pengrajin lontong di Kampung Lontong RW 6 Kelurahan Kupang Krajan yaitu sebanyak 30 perajin dan yang bersedia dan bisa diwawancarai sebanyak 17 orang. Hasil Penelitian menunjukkan untuk peningkatan daya saing dari sisi Asets adalah perlu pelatihan bagi pengusaha untuk menambah kompetensinya dengan menguasai manajemen keuangan dan manajemen sumber daya manusia, sedangkan dari sisi Proses adalah dengan melakukan kerjasama dengan akademisi dalam memanfaatkan hasil penelitian dan pengembangan melakukan tertib administrasi SDM dan organisasinya meskipun skala usahanya masih UMK, mengikutsertakan diri dan pegawainya bila ada pelatihan serta meningkatkan kemampuan kerjasama pengusaha lontong dalam pemenuhan pasokan bahan dan pemasaran, terakhir dari sisi Performa adalah perlu integrasi peran pengusaha, pemerintah dan akademisi dalam penelitian dan pengembangan inovasi teknologi dan produk baru.
The effects of diachronous surface uplift of the European Alps on regional climate and the oxygen isotopic composition of precipitation
Authors: Boateng Daniel , Mutz Sebastian G. , Ballian Armelle , Meijers Maud J. M. , Methner Katharina , Botsyun Svetlana , Mulch Andreas , Ehlers Todd A. 
Published: November 2023

Abstract. This study presents the simulated response of regional climate and the oxygen isotopic composition of precipitation (δ18Op) to different along-strike topographic evolution scenarios. These simulations are conducted to determine if the previously hypothesized diachronous surface uplift in the Western and Eastern Alps would produce δ18Op signals in the geologic record that are sufficiently large and distinct to be detected using stable isotope paleoaltimetry. We present a series of topographic sensitivity experiments conducted with the water-isotope-tracking atmospheric general circulation model (GCM) ECHAM5-wiso. The topographic scenarios are created from the variation of two free parameters, (1) the elevation of the Western–Central Alps and (2) the elevation of the Eastern Alps. The results indicate Δδ18Op values (i.e., the difference between δ18Op values at the low- and high-elevation sites) of up to −8 ‰ along the strike of the Alps for the diachronous uplift scenarios, primarily due to changes in orographic precipitation and adiabatic lapse rate driven localized changes in near-surface variables. These simulated magnitudes of Δδ18Op values suggest that the expected isotopic signal would be significant enough to be preserved and measured in geologic archives. Moreover, the simulated slight δ18Op differences of 1 ‰–2 ‰ across the low-elevation sites support the use of the δ–δ paleoaltimetry approach and highlight the importance of sampling far-field low-elevation sites to differentiate between the different surface uplift scenarios. The elevation-dependent rate of change in δ18Op (“isotopic lapse rate”) varies depending on the topographic configuration and the extent of the surface uplift. Most of the changes are significant (e.g., −1.04 ‰ km−1 change with slope error of ±0.09 ‰ km−1), while others were within the range of the statistical uncertainties (e.g., −0.15 ‰ km−1 change with slope error of ±0.13 ‰ km−1). The results also highlight the plausible changes in atmospheric circulation patterns and associated changes in moisture transport pathways in response to changes in the topography of the Alps. These large-scale atmospheric dynamics changes can complicate the underlying assumption of stable isotope paleoaltimetry and therefore require integration with paleoclimate modeling to ensure accurate reconstruction of the paleoelevation of the Alps.
Estudantes-atletas: reflexões acerca de seu desenvolvimento
Authors: Peruchi Giovana , Victor Alves Melo Sandro , Teixeira Quinaud Ricardo 
Published: November 2023

Este estudo teve como objetivo refletir sobre o desenvolvimento do estudante-atleta tendo como modelo teórico o Modelo de Desenvolvimento Esportivo proposto pelo Comitê Olímpico do Brasil- COB. Ao longo do texto, é discutido o estudante-atleta e seus desafios ao seguir a carreira-dupla, bem como sobre a dupla carreira no Brasil e no mundo. Por fim, sugere-se a criação de uma legislação nacional e de políticas institucionais que promovam o acesso, a permanência e a finalização da formação destes estudantes-atletas.
Resistencias caleidoscópicas al capitalismo contemporáneo: género, trabajo y despojo
Authors: Brown Brenda , Cufré Sara , Garcés Santiago 
Published: November 2023

Escribir la introducción a este número especial nos llena de alegría. Es el signo de la inminente llegada de ese final que cristaliza, en papel, el trabajo de muchos años. La síntesis colectiva de vínculos interdisciplinarios, de reflexiones transfronterizas, de cuerpos rebeldes con miradas críticas. Quienes editamos este dossier nos conocimos compartiendo espacios dedicados al estudio de la relación entre capital y trabajo, entre tesis de maestrías y de doctorados. Compartimos jornadas académicas y también días de lucha. Dedicamos horas de debate y trabajo colectivo que condujeron a este punto de llegada en el que reivindicamos una mirada caleidoscópica del capitalismo en el siglo XXI.
Abya Yala (América Latina) atraviesa una crisis multifacética que combina la intensificación del extractivismo con el avance de las “nuevas derechas”, reformas que marcan retrocesos en derechos sociales con la precarización de las vidas, crisis de ingresos y endeudamiento masivo, nuevas formas de desposesión a partir del terror y el avance del crimen organizado.
Las múltiples formas de precarización de las vidas están ancladas en una matriz extractivista, de explotación y desposesión que se reactualiza y se intensifica cada vez más. Y que se resiste. Esa resistencia a las formas de despojo y a las diversas formas de explotación se puede rastrear a lo largo de todo el continente y del mundo. En este dossier, cada uno de los textos nos ilustra sobre cómo se están llevando a cabo estos procesos en territorios y cuerpos concretos.
Recuperamos la idea del caleidoscopio porque es un artefacto que permite crear diferentes figuras geométricas a partir del juego de colores, luces y sombras. Arroja imágenes en un momento determinado que luego desaparecen y reaparecen transformadas en la medida en que se utiliza. A partir de esta metáfora, pensamos al capitalismo como una totalidad simultáneamente constituida por relaciones económicas, políticas, sociales, culturales, ambientales, emocionales, subjetivas, que puede arrojar diferentes imágenes a partir de la rotación del “cilindro” teórico y metodológico, en función del momento histórico, de los cuerpos y del territorio. Cada texto de este dossier puede pensarse en sí mismo como una propuesta para jugar con el caleidoscopio. En su conjunto, constituyen un aporte para los estudios feministas que, desde hace tiempo, hacen mover ese cilindro para ampliar la crítica clásica del marxismo al capitalismo, extender las fronteras para su aprehensión y, en consecuencia, ampliar los horizontes para su transformación.
Avoiding Compartment Syndrome, Vascular Injury, and Neurologic Deficit in Tibial Osteotomy: An Observational Study of 108 Limbs
Authors: Hoellwarth Jason Shih , Geffner Adam , Fragomen Austin T. , Reif Taylor J. , Rozbruch S. Robert 
Published: November 2023

Introduction:
Tibial deformities are common, but substantial concern may be associated with corrective osteotomy regarding major complications reported in classic literature. Such studies chiefly focused on high tibial osteotomy, with relatively little investigation of other areas and types of deformity. The primary aim of this study was to identify the rate of compartment syndrome, vascular injury, nerve injury, and other major complications after elective tibial osteotomy.

Methods:
One hundred eight tibia osteotomies performed during 2019 to 2021 were evaluated, representing all tibia osteotomies except situations of existing infection. A retrospective chart review was performed to identify patient demographics, surgical indications, anatomic location of osteotomy, fixation used, and complications prompting additional surgery.

Results:
The most common osteotomy locations were high tibial osteotomy (35/108 = 32%, 32/35 = 91% medial opening, and 3/35 = 9% medial closing), proximal metaphysis (30/108 = 28%), and diaphysis (32/108 = 30%). The most common fixation was plate and screw (38/108 = 35%) or dynamic frame (36/108 = 33%). Tranexamic acid was administered to 107/108 = 99% of patients and aspirin chemoprophylaxis was used for 83/108 = 86%. A total of 33/34= 97% of anterior compartment prophylactic fasciotomies were performed for diaphyseal or proximal metaphysis osteotomies. No events of compartment syndrome, vascular injury, nerve injury, or pulmonary embolism occurred. One patient required débridement to address infection. Additional surgery for delayed/nonunion occurred for nine segments (8%). Additional surgery for other reasons were performed for 10 segments (9%), none resulting in reduced limb function.

Conclusion:
Tibial osteotomy can be safely performed for a variety of indications in a diverse range of patients, without a notable risk of the most feared complications of compartment syndrome, vascular injury, and neurologic deficit. Prophylactic fasciotomy and reducing postoperative bleeding using tranexamic acid, along with location-specific safe surgical techniques, may help prevent major complications and thereby facilitate optimized deformity care.