bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between serum cholinesterase and the prevalence of atrial fibrillation in Chinese hypertensive population: a cross-sectional study
Authors: Xue Wenjing , Wei Yi , Hu Yuanhui 
Published: November 2023

Abstract
Background
Atrial fibrillation (AF) is a very common arrhythmia with significant incidence rate and mortality. Several studies have shown a notable correlation between non-alcoholic fatty liver disease (NAFLD) and AF. It has been observed that serum cholinesterase (SChE) levels are elevated in individuals with fatty liver. However, the relationship between the SChE index and AF is still unclear. Therefore, the purpose of this study is to explore the association between the SChE index and the prevalence of AF in patients with hypertension.

Method
We collected cross-sectional data from January 2018 to April 2021 based on a retrospective study of cardiovascular disease. A total of 748 patients with hypertension were included, of whom 165 had AF. We used logistic regression models to test the relationship between SChE and the prevalence of AF in hypertensive patients.

Result
In hypertensive patients, the SChE index was significantly associated with AF (OR = 0.723, P < 0.001). After adjusting for potential confounding factors, this correlation was still significant (OR = 0.778, P < 0.001). The stability of the model was verified by adjusting the variable type of SChE. The data were further stratified according to whether the patient had fatty liver. In the stratified data, the correlation between SChE and atrial fibrillation was still significant (P < 0.05).

Conclusion
Our study showed that SChE was significantly negatively correlated with the occurrence of AF in patients with hypertension. And this correlation was not affected by whether the patient had fatty liver.
LncRNA MAFG-AS1 is involved in human cancer progression
Authors: Li Penghui , Ma Xiao , Gu Xinyu 
Published: November 2023

AbstractLong noncoding RNAs (lncRNAs) refer to a type of non-protein-coding transcript of more than 200 nucleotides. LncRNAs play fundamental roles in disease development and progression, and lncRNAs are dysregulated in many pathophysiological processes. Thus, lncRNAs may have potential value in clinical applications. The lncRNA, MAF BZIP Transcription Factor G (MAFG)-AS1, is dysregulated in several cancer, including breast cancer, lung cancer, liver cancer, bladder cancer, colorectal cancer, gastric cancer, esophagus cancer, prostate cancer, pancreatic cancer, ovarian cancer, and glioma. Altered MAFG-AS1 levels are also associated with diverse clinical characteristics and patient outcomes. Mechanistically, MAFG-AS1 mediates a variety of cellular processes via the regulation of target gene expression. Therefore, the diagnostic, prognostic, and therapeutic aspects of MAFG-AS1 have been widely explored. In this review, we discuss the expression, major roles, and molecular mechanisms of MAFG-AS1, the relationship between MAFG-AS1 and clinical features of diseases, and the clinical applications of MAFG-AS1.
A review on factors related to patient comfort experience in hospitals
Authors: Tian Yu 
Published: November 2023

AbstractThe creation of a welcoming hospital atmosphere is necessary to improve patient wellbeing and encourage healing. The goal of this study was to examine the variables affecting hospitalised patients' comfort. The study procedure included a thorough search of the Web of Science and Scopus databases, as well as the use of software analytic tools to graphically map enormous literature data, providing a deeper understanding of the linkages within the literature and its changing patterns. Insights from a range of disciplines, including engineering, psychology, immunology, microbiology, and environmental science, were included into our study using content analysis and clustering approaches. The physical environment and the social environment are two crucial factors that are related to patient comfort. The study stress the need of giving patient comfort a top priority as they heal, especially by tackling indoor air pollution. Our research also emphasises how important hospital care and food guidelines are for improving patient comfort. Prioritising patients who need specialised care and attention, especially those who have suffered trauma, should be the focus of future study. Future research in important fields including trauma, communication, hospital architecture, and nursing will be built on the findings of this study. To enhance research in these crucial areas, worldwide collaboration between experts from other nations is also advised. Although many studies stress the significance of patient comfort, few have drawn conclusions from a variety of disciplines, including medicine, engineering, immunology, microbiology, and environmental science, the most crucial issue of thoroughly researching the improvement of patient comfort has not been addressed. Healthcare workers, engineers, and other professions will benefit greatly from this study's investigation of the connection between hospital indoor environments and patient comfort.
Association between prognostic nutritional index and peritoneal dialysis discontinuation: a retrospective cohort study
Authors: Miyasato Yoshikazu , Morinaga Jun , Inoue Hideki , Nakayama Yushi , Adachi Masataka , Izumi Yuichiro , Kakizoe Yutaka , Mizumoto Teruhiko , Nakagawa Terumasa , Fujimoto Daisuke , Ono Makoto , Oda Akira , Kuwabara Takashige , Mukoyama Masashi 
Published: November 2023

Abstract
Background
Malnutrition is associated with discontinuing peritoneal dialysis (PD). The prognostic nutritional index (PNI), composed of serum albumin level and total lymphocyte count, has been suggested as a prognostic marker for mortality in patients undergoing PD. However, the relationship between PNI and PD discontinuation has not yet been well addressed. We evaluated the relationship between PNI and PD discontinuation in patients with end-stage kidney disease who initiated PD treatment.

Methods
This retrospective cohort study included patients who underwent PD at a single academic hospital between 2007 and 2022. We examined the association between PNI (< 40 vs. ≥ 40) and PD discontinuation using Cox proportional hazards regression models. We used restricted cubic spline analysis to examine the continuous associations between the PNI and outcomes.

Results
The mean age (and standard deviation) of the 91 patients was 57.1 ± 13.4 years; 72 (79.1%) discontinued PD during the median follow-up period of 25.0 months. Lower PNI was associated with an increased risk of PD discontinuation. The hazard ratios (95% confidence intervals) with three levels of adjustments were 1.74 (1.08, 2.79), 2.21 (1.32, 3.66), and 1.81 (1.01, 3.24) (reference: PNI ≥ 40). Restricted cubic spline analysis showed that a PNI < 40 was continuously associated with a higher risk of PD discontinuation.

Conclusion
A lower PNI (< 40) was associated with a higher risk of PD discontinuation. Our findings suggest that evaluating the PNI may help identify patients at high risk of PD discontinuation and lead to appropriate nutritional management for dialysis maintenance.
Development and psychometric evaluation of TEXP-Q: a questionnaire measuring transition and transfer experiences in emerging adults with type 1 diabetes
Authors: Vallmark Mikaela , Brorsson Anna Lena , Sparud-Lundin Carina , Bratt Ewa-Lena , Moons Philip , Saarijärvi Markus , Mora Mariela Acuña 
Published: November 2023

Abstract
Background
During transition to adulthood and transfer to adult healthcare, emerging adults with chronic conditions are at risk of deteriorating disease control, well-being, and acute, as well as long-term complications. Despite an increasing call for person-centred healthcare services attuned to young peoples’ needs, few validated instruments exist pinpointing adolescents’ and emerging adults’ experiences of preparation for transition and transfer. Thus, the overarching purpose of this study was to develop a person-centred, clinically applicable instrument (Transitional care EXPeriences Questionnaire, TEXP-Q) adjustable to different chronic conditions, although the focus in the present study was Type 1 Diabetes. The specific aim was, therefore, to describe the development and psychometric evaluation of TEXP-Q in emerging adults with Type 1 Diabetes.

Methods
Initial development of the TEXP-Q was inspired by existing research. Items were formulated in accordance with consensus recommendations for developing patient-reported measures, and extra consideration was taken to ensure person-centredness. Psychometric evaluation comprised two phases: In phase I, data from cognitive interviews, content validity indexing, and judgement of an expert panel provided information on face and content validity. In phase II, data from a cross-sectional study conducted at eight adult diabetes outpatient clinics in Sweden (n = 163) allowed for explorative factor analysis (EFA), as well as calculation of content validity, reliability and responsiveness.

Results
Combining results from cognitive interviews, content validity index values and expert panel judgement, a test version of TEXP-Q was developed, the content and face validity of which were considered good. This version consisted of 17 items answered on a five-point Likert scale, and three open-ended questions answered in free text. During EFA, four items were removed, and a three-factor solution was recognised as most adequate, accounting for 60% cumulative variance and one single cross-loading. After EFA, the instrument comprised 13 questions, divided into three latent factors. Cronbach’s alpha for the complete instrument was 0.866, which indicates good internal consistency. Crohnbach’s alpha approximated to 0.8 for all factors respectively.

Conclusion
TEXP-Q is a newly developed, person-centred instrument which has proven to be both valid and reliable when applied to youths with T1D. The questionnaire fills a need for instruments focusing on emerging adults’ experiences of preparation for transition and transfer.
Effect of primary versus secondary splinting impression techniques on the passive fit of screw-retained implant prosthesis: a randomized clinical trial
Authors: Algabri Radwan Saleh , Altayyar Sadeq Ali , Abo-Alrejal Hanan Omar , Alsourori Ali Abdulghani , Alshaibani Dhafer Abdulwasea , Mostafa Marwa Hassan 
Published: November 2023

Abstract
Background
The utilization of splinting techniques for impression copings is commonly advised for complex implant-supported prostheses, as it can enhance the fit of these prostheses. However, there is limited understanding regarding the impact of the secondary splinting of implant analogues, on the passive fit of the prostheses. Limited data are available on the secondary splinting of implant analogues before pouring the impression and its comparison with the primary technique of intraoral splinting of impression copings prior to impression making.

Objectives
This study's objective was to determine the impact of the primary versus secondary impression splinting techniques using resin on the passive fit of screw-retained prosthesis.

Material and methods
This randomized clinical trial (RCT) involved two parallel groups consisting of 14 completely edentulous patients, with seven patients in each group. Each patient received a total of eight implants, four implants per arch, resulting in a total of 28 screw-retained prostheses. Two different impression splinting techniques were employed. Group (1) utilized the primary splinting technique, where the impression copings were splinted before taking the impression. In contrast, Group (2) utilized the secondary splinting technique, where the implant analogues were splinted before pouring the impression material. To evaluate the passivity of the screw-retained prostheses in both groups, a single-screw test (one-screw test) was used. Additionally, supplementary methods, including the screw resistance test, were employed.

Results
The findings of this RCT revealed higher passivity scores for secondary splinting impression pouring technique with a statistically significant difference (P = 0.082). There was a 2.2-fold greater frequency of non-passivity in the primary splinted method. In group (2), the likelihood of non-passivity was four times higher for upper arches prostheses, while there was no significant difference (P = 0.5) observed in both groups for lower arches prostheses.

Conclusions
The study found that using the secondary splinting impression pouring technique resulted in greater passivity of the implant prostheses compared to the primary splinting impression technique.
A review of radial basis function with applications explored
Authors: Arora Geeta , KiranBala  , Emadifar Homan , Khademi Masoumeh 
Published: November 2023

AbstractPartial differential equations are a vital component of the study of mathematical models in science and engineering. There are various tools and techniques developed by the researchers to solve the differential equations. The radial basis functions have proven to be an efficient basis function for approximating the solutions to ordinary and partial differential equations. There are different types of radial basis function methods that have been developed by the researchers to solve various well known differential equation. It has been developed for approximation of the solution with various approaches that lead to the development of hybrid methods. Radial basis function methods are widely used in numerical analysis and statistics because of their ability to deal with meshless domain. In this work, the different radial basis function approaches were investigated along with the focus on the strategies being addressed to find the shape parameter value. The mathematical formulations of the various radial basis function methods are discussed along with the available shape parameters to get the optimal value of the numerical solutions. The present work will lay a foundation to understand the development of the radial basis functions that could lead to a play an important role in development of method thereafter.
Empagliflozin versus Sitagliptin as add-on dual therapy in Egyptian patients with type 2 diabetes inadequately controlled with Metformin: a 12-week randomized, open-label, parallel-group trial
Authors: Zakaraia Haitham G. , Salem Heba F. , Mostafa Mostafa A. A. , Ali Ahmed M. , Rabea Hoda M. 
Published: November 2023

Abstract
Background
Diabetes is one of the world’s most widespread conditions, and diabetic patients are among the most likely to engage in fierce battles with this chronic disease. Which group should be added-on as a dual therapy for Egyptian patients with type 2 diabetes and inadequate glycemic management, HbA1c ≥ 7.0% and ≤ 10% (≥ 53 and ≤ 86 mmol/mol), following not less than 3 months of metformin and diet therapy, is still up for debate. Based on this ambiguity, we designed our study to compare the safety and efficacy of sitagliptin 50 mg (n = 85) with empagliflozin 12.5 mg (n = 85) twice daily as an adjunctive therapy to metformin and diet for a further 12 weeks. HbA1c after 12 weeks of open-label therapy was the major outcome measure.

Results
After 12 weeks of treatment, empagliflozin drastically lowered HbA1c, FPG, PP, body weight, and triglycerides from baseline while significantly increasing LDL, total cholesterol, and HDL. On the other hand, sitagliptin significantly reduced FPG, PP (with a no discernable alteration in HbA1c), body weight, and triglycerides while significantly increasing HDL (P ≤ 0.001 for all comparisons). Comparing the two groups, empagliflozin significantly reduced HbA1c, FPG, and PP while significantly increasing LDL and triglycerides than sitagliptin (P < 0.001 for all except FPG, P = 0.005). More patients receiving empagliflozin 12.5 mg than sitagliptin 50 mg twice daily reported adverse events during open-label treatment (11.8% vs. 8.2%, respectively).

Conclusions
In type 2 diabetic Egyptian patients uncontrolled with metformin and diet, empagliflozin was superior to sitagliptin as regards glycemic control, weight, and SBP/DBP reduction.
Mitral annular disjunction in surgical mitral valve prolapse: prevalence, characteristics and outcomes
Authors: Gray Rhys , Indraratna Praveen , Cranney Gregory , Lam Hebe , Yu Jennifer , Mathur Gita 
Published: November 2023

Abstract
Background
There is a paucity of literature regarding outcomes of patients with mitral valve prolapse (MVP) and mitral annular disjunction (MAD) after mitral surgery, with many unanswered questions including the post-surgical persistence of MAD, effect of MAD on mitral valve reparability, and incidence of arrhythmia after mitral valve surgery. We aimed to examine the prevalence, imaging characteristics and clinical associations of mitral annular disjunction among patients undergoing mitral valve surgery for mitral valve prolapse, as well as outcomes after surgery including the persistence of MAD, arrhythmic events and excess mortality.

Results
A retrospective analysis of 111 consecutive patients who underwent mitral valve surgery for MVP was performed. A total of 32 patients (28.8%) had MAD. Patients with MAD were younger (64 vs 67 yrs, p = 0.04), with lower rates of hypertension (21.9% vs 50.6%, p = 0.01) and hyperlipidaemia (25% vs 50.6%; p = 0.01) and were more likely to be female (43.8% vs 21.4%, p = 0.04) with myxomatous leaflets > 5mm (90.6% vs 15.2%, p =  < 0.01) and bileaflet prolapse (31.3% vs 10.1%, p = 0.02). Mitral valve repair was performed in 29/32 patients (90.6%) in the MAD positive group, and no patients had the persistence of MAD post-surgery. Post-operative ventricular arrhythmia was higher in the MAD positive group (28.13% vs 11.69%, p = 0.04) with no difference in mortality, 30-day hospital re-admission, or post-operative mitral regurgitation between patients with and without MAD over 3.91 years of follow up.

Conclusion
In this study of consecutive patients with MVP undergoing surgery, MAD was a common finding (almost 1 in 3). MAD does not compromise mitral valve surgical reparability, and both repair and replacement are effective at correcting disjunction. Our data suggest that concurrent MAD in MVP patients undergoing surgery has no significant effect on post surgical outcomes. Further research as to whether this patient cohort requires post-surgical arrhythmia monitoring is warranted.
A research of a strategy to balance the importance and dispersion of multiple critical nodes
Authors: Cui Dong-Xu , He Jia-Lin , Lin Feng , Ru Jie , Ren Wei-Ping 
Published: November 2023

Abstract
Maximizing the range of disease or information spread is a hot research topic in complex networks. In particular, the dispersion among a group of nodes and the spreading ability of a single node are two vital factors in the propagation process. However, although some traditional algorithms have considered both factors, they have failed to address the balance between them. To solve this problem, this paper first proposes two metrics to quantify the dispersion of a group of nodes and the local spreading ability of a single node, then designs an objective function fusing these two metrics, which automatically searches for a balance between these two vital factors during the optimization process. We evaluate the proposed algorithm against seven baseline algorithms on three synthetic networks and nine real networks based on the classic susceptible-infected-recovered (SIR) model. Experimental results show that our algorithm is better than some of the centrality-based and heuristic algorithms in the final propagation scale.
Insights into RNA N6-methyladenosine in Glucose and Lipid Metabolic Diseases and Their Therapeutic Strategies
Authors: Wu Yifan , Zeng Yuan , Ren Yaolin , Yu Jie , Zhang Qian , Xiao Xinhua 
Published: November 2023

Abstract
The incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease, is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is 1 type of posttranscriptional RNA modification, and research has shown that it plays a crucial role in several metabolic diseases. m6A methylation is reversibly and dynamically regulated by methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). Dysregulation of RNA m6A modification is related to different metabolic processes. Targeting RNA m6A methylation is a potential treatment strategy for these chronic metabolic diseases. This review discusses studies on RNA m6A modification in metabolic diseases and existing therapeutic drugs, with the aim of providing a concise perspective on its potential applications in managing metabolic disorders.
Impact of paramedics carrying just-in-case end-of-life care medication
Authors: O'Brian Edward , Chohan Andeep , Sewell Bernadette , Pease Nikki 
Published: November 2023

Background:Early in the COVID-19 pandemic, it was predicted that frail community patients with symptoms of severe COVID-19 infection may need urgent symptom management—and that unless they had already been identified as being in their last weeks of life, they would be unlikely to have just-in-case (JIC) medications at home. The Welsh Ambulance Services NHS Trust therefore placed JIC medications on emergency ambulances to increase symptom management options for paramedics treating patients with symptoms of severe COVID-19 infection and/or associated with advanced end-stage illness.Methods:A review of medications to palliate symptoms of severe COVID-19 infection and advanced and terminal illness was undertaken. A verbal order process was implemented, allowing prescription-only medications to be administered by paramedics. Guidance, training and data capture processes were designed and implemented.Results:Symptoms associated with advanced cancer were the main reason for giving ambulance-based JIC medications, and midazolam and morphine were the most administered medicines. No adverse incidents were reported or recorded.Conclusion:Ambulance-based JIC medications were and continue to be appropriately administered, irrespective of life-limiting illness diagnosis. Although carrying JIC medicines on ambulances was introduced in response to the COVID-19 pandemic, 12 months of data collection indicates this is a safe, cost-effective, patient-centred practice.
LA HIJRA DE LAS MENORES EN EL CINE FRANCÉS: LE CIEL ATTENDRA Y NE M’ABANDONNE PAS
Authors: GEORGEAULT LENA 
Published: November 2023

En 2014, la marcha de varios adolescentes franceses hacia la zona sirio-iraquí alertó a la opinión pública sobre la captación de menores de edad por organizaciones yihadistas y despertó el interés de los cineastas. Estrenadas en 2016 y centradas en chicas menores de edad cuyo deseo es hacer la hijra, las películas Le ciel attendra, de Marie-Castille Mention-Schaar, y Ne m’abandonne pas, de Xavier Durringer, constituyen dos percepciones sobre la hijra entre menores. Este artículo analiza las visiones reflejadas en los dos filmes y discute si estas dejan espacio para la crítica a las autoridades. Pretende así indagar sobre el papel de estas películas como aliadas de la democracia en la lucha contra el yihadismo e identificar los paradigmas que sustentan sus representaciones. El análisis concluye que los dos filmes asumen un importante compromiso social, puesto que constituyen obras divulgativas y herramientas de prevención y apuntan los fallos de las autoridades. Sin embargo, al coincidir directamente con las narrativas oficiales debido a la influencia de la antropóloga Dounia Bouzar, que colaboró tanto con el Gobierno de Francia en materia de prevención de la radicalización como con los realizadores de las películas, estas renuncian a la posibilidad de ampliar las perspectivas sobre el fenómeno. Más bien, se limitan a reproducir la visión de Dounia Bouzar, quien concibe la radicalización yihadista como un proceso de adoctrinamiento sectario, relativizando así la responsabilidad de las adolescentes radicalizadas.