bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global malaria predictors at a localized scale
Authors: Skinner Eloise B. , Childs Marissa L. , Thomas Matthew B. , Cook Jackie , Sternberg Eleanore D. , Koffi Alphonsine A. , N’Guessan Raphael , Wolie Rosine Z. , Oumbouke Welbeck A. , Ahoua Alou Ludovic P. , Brice Serge , Mordecai Erin A. 
Published: November 2023

AbstractMalaria is a life-threatening disease caused byPlasmodiumparasites transmitted byAnophelesmosquitoes. In 2021, more than 247 million cases of malaria were reported worldwide, with an estimated 619,000 deaths. While malaria incidence has decreased globally in recent decades, some public health gains have plateaued, and many endemic hotspots still face high transmission rates. Understanding local drivers of malaria transmission is crucial but challenging due to the complex interactions between climate, entomological and human variables, and land use. This study focuses on highly climatically suitable and endemic areas in Côte d’Ivoire to assess the explanatory power of coarse climatic predictors of malaria transmission at a fine scale. Using data from 40 villages participating in a randomized controlled trial of a household malaria intervention, the study examines the effects of climate variation over time on malaria transmission. Through panel regressions and statistical modeling, the study investigates which variable (temperature, precipitation, or entomological inoculation rate) and its form (linear or unimodal) best explains seasonal malaria transmission and the factors predicting spatial variation in transmission. The results highlight the importance of temperature and rainfall, with quadratic temperature and all precipitation models performing well, but the causal influence of each driver remains unclear due to their strong correlation. Further, an independent, mechanistic temperature-dependent R0model based on laboratory data aligns well with observed malaria incidence rates, emphasizing the significance and predictability of temperature suitability across scales. By contrast, entomological variables, such as entomological inoculation rate, were not strong predictors of human incidence in this context. Finally, the study explores the predictors of spatial variation in malaria, considering land use, intervention, and entomological variables. The findings contribute to a better understanding of malaria transmission dynamics at local scales, aiding in the development of effective control strategies in endemic regions.
Post-ischemic triiodothyronine treatment improves stroke outcome by stabilizing the blood-brain barrier
Authors: Ullrich Daniel , Führer-Sakel Dagmar , Heuer Heike , Mayerl Steffen , Haupeltshofer Steffen , Schmitt Linda-Isabell , Leo Markus , Hagenacker Tim , Kleinschnitz Christoph , Langhauser Friederike 
Published: November 2023

AbstractThyroid hormones control a variety of processes in the central nervous system and influence its response to different stimuli, such as ischemic stroke. Post-stroke administration of triiodothyronine (T3) has been reported to substantially improve outcomes, but the optimal dosage and time window remain elusive. To this end we investigated the consequences of T3 treatment in an experimental model of ischemic stroke in mice. Our research demonstrated a dose-dependent protective effect of T3 by reducing infarct volumes, with the optimal T3 dosage identified as 25 µg/kg. In addition, we observed a time-dependent effectiveness that was most pronounced when T3 was administered 1 h after transient middle cerebral artery occlusion, with a gradual reduction in efficacy at 4.5 h, and no reduction in infarct volumes when T3 was injected with an 8 h delay. This protective effect persisted for 72 h post-tMCAO, and had accelerated the recovery of motor function by day 3. In-depth investigations further revealed stabilization of the blood-brain barrier, indicated by reduced extravasation of Evans Blue and diminished aquaporin-4 expression, with reduced inflammation and less cell death as underlying reasons. Our findings suggest that thyroid hormones may be a promising intervention for clinical stroke.
The unique function of Runx1 in skeletal muscle differentiation and regeneration is mediated by an ETS interaction domain
Authors: Yu Meng , Thorner Konrad , Parameswaran Sreeja , Wei Wei , Yu Chuyue , Lin Xinhua , Kopan Raphael , Hass Matthew R. 
Published: November 2023

AbstractThe conserved Runt-related (RUNX) transcription factor family are well-known master regulators of developmental and regenerative processes.Runx1andRunx2are both expressed in satellite cells (SC) and skeletal myotubes. Conditional deletion ofRunx1in adult SC negatively impacted self-renewal and impaired skeletal muscle maintenance.Runx1-deficient SC retainRunx2expression but cannot support muscle regeneration in response to injury. To determine the unique molecular functions of Runx1 that cannot be compensated by Runx2 we deletedRunx1in C2C12 that retainRunx2expression and established that myoblasts differentiation was blockedin vitrodue in part to ectopic expression ofMef2c,a target repressed byRunx1. Structure-function analysis demonstrated that the Ets-interacting MID/EID region of Runx1, absent from Runx2, is critical to regulating myoblasts proliferation, differentiation, and fusion. Analysis of in-house and published ChIP-seq datasets fromRunx1(T-cells, muscle) versusRunx2(preosteoblasts) dependent tissue identified enrichment for a Ets:Runx composite site inRunx1-dependent tissues. Comparing ATACseq datasets from WT and Runx1KO C2C12 cells showed that the Ets:Runx composite motif was enriched in peaks open exclusively in WT cells compared to peaks unique to Runx1KO cells. Thus, engagement of a set of targets by the RUNX1/ETS complex define the non-redundant functions ofRunx1.
Transcriptional drift in aging cells: A global de-controller
Authors: Matsuzaki Tyler , Weistuch Corey , de Graff Adam , Dill Ken A , Balázsi Gábor 
Published: November 2023

AbstractAs cells age, they undergo a remarkable global change: Intranscriptional drift, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from agingCaenorhabditis elegansworms, we find that the upregulated genes code for sensory proteins upstream of stress responses and downregulated genes are growth- and metabolism-related. We propose a simple mechanistic model for how such global coordination of multi-protein expression levels may be achieved by the binding of a single ligand that concentrates with age. A key implication is that a cell’s own responses are part of its aging process, so unlike for wear-and-tear processes, intervention might be able to modulate these effects.
Prevalence of plasmodium infection and associated risk factors among household members in Southern Ethiopia: Mult-site cross-sectional study
Authors: Yutura Girma , Massebo Fekadu , Eligo Nigatu , Kochora Abena , Wegayehu Teklu 
Published: November 2023

AbstractDespite continuous prevention and control strategies in place, malaria remains a major public health problem in sub-Saharan Africa including Ethiopia. This study is, therefore, aimed to determine the prevalence of plasmodium infection and associated risk factors in selected ruralkebelesin southern Ethiopia. A community-based cross-sectional study was conducted between January and June 2019. Mult-stage sampling techniques were employed to select the study districts andkebelesfrom four zones. Blood sample were taken from 1674 participants by finger prick and thin and thick smears were examined by microscopy. Socio-demographic data as well as risk factors for malaria infection were collected using questionnaires. Bivariate and multivariate logistic regressions were used to analyze the data. The overall prevalence of malaria in the study localities was 4.5% (76/1674). The prevalence was varied among the study localities with high prevalence in Bashilo (14.6%; 33/226) followed by Mehal Korga (12.1%; 26/214).Plasmodium falciparumwas the dominant parasite accounted for 65.8% (50/76), whileP. vivaxaccounted 18.4% (14/76). Co-infection ofP. falciparumandP. vivaxwas 15.8% (12/76). The prevalence of malaria was 7.8% (27/346) in age less than 5 years and 7.5% (40/531) in 5-14 years. The age groups >14years were less likely infected with plasmodium parasite (AOR=0.14, 95% CI 0.02-0.82). Asymptomatic individuals more likely had malaria infection (AOR = 28.4, 95% CI 011.4-70.6). Individuals living proximity to mosquito breeding sites have higher malaria infection (AOR = 6.17, 95% CI 2.66 - 14.3). Malaria remains a public health problem in the study localities with lower age group and asymptomatic individuals had higher plasmodium infection. Thus, malaria prevention and control strategies targeting children and asymptomatic cases are crucial to reduce malaria related morbidity and mortality.
Prediction of soil degree of compaction based on machine learning: a case study of two fine-grained soils
Authors: Ran Yuling , Bai Wei , Kong Lingwei , Fan Henghui , Yang Xiujuan , Li Xuemei 
Published: November 2023

PurposeThe purpose of this paper is to develop an appropriate machine learning model for predicting soil compaction degree while also examining the contribution rates of three influential factors: moisture content, electrical conductivity and temperature, towards the prediction of soil compaction degree.Design/methodology/approachTaking fine-grained soil A and B as the research object, this paper utilized the laboratory test data, including compaction parameter (moisture content), electrical parameter (electrical conductivity) and temperature, to predict soil degree of compaction based on five types of commonly used machine learning models (19 models in total). According to the prediction results, these models were preliminarily compared and further evaluated.FindingsThe Gaussian process regression model has a good effect on the prediction of degree of compaction of the two kinds of soils: the error rates of the prediction of degree of compaction for fine-grained soil A and B are within 6 and 8%, respectively. As per the order, the contribution rates manifest as: moisture content > electrical conductivity >> temperature.Originality/valueBy using moisture content, electrical conductivity, temperature to predict the compaction degree directly, the predicted value of the compaction degree can be obtained with higher accuracy and the detection efficiency of the compaction degree can be improved.
The dark side of advertising: promoting unhealthy food consumption
Authors: Deshpande Bilwa , Kaur Puneet , Ferraris Alberto , Yahiaoui Dorra , Dhir Amandeep 
Published: November 2023

Purpose
Scholars have noted the impact of advertising on unhealthy food consumption. However, a systematic literature review (SLR) on this topic is currently lacking. This study aims to find, analyze and synthesize prior literature to set the stage for future researchers and practitioners. It also uncovers research gaps, suggests potential research questions and presents a conceptual framework for use in future research.

Design/methodology/approach
This paper catalogs and synthesizes topic-related literature by using the time-tested SLR methodology. It identifies and analyzes 99 relevant studies that have addressed the impact of advertising on unhealthy food consumption. Research profiling of the selected studies supported the synthesis of key themes in the extant literature.

Findings
The authors identify three key thematic foci: a) viewer attributes pertaining to excessive unhealthy food consumption, b) advertisement attributes pertaining to excessive unhealthy food consumption and, c) unhealthy food consumption regulation. Within these themes, the authors also identify some subthemes, presenting specific advertising and viewer attributes that contribute to unhealthy food consumption. The authors further develop a conceptual framework based on the stimulus-organism-response (S-O-R) model, summarizing the findings of the study. This could aid future researchers and practitioners in their design of certain strategies.

Research limitations/implications
The study uncovers various gaps in the extant literature and suggests potential areas that can be examined by scholars. From a practical perspective, the study recommends certain actionable strategies for policymakers, helping customers to achieve the long-term goal of obesity reduction.

Practical implications
From the perspective of practice, the study recommends certain actionable strategies for policymakers helping customers achieve the long-term goal of obesity reduction.

Originality/value
The current study makes a novel contribution to the research on advertising and unhealthy food consumption by identifying theme-based research gaps in the existing literature, mapping those with potential research questions and presenting a conceptual framework based on the S-O-R model. Based on the findings, the study also proposes five potential research models examining diverse aspects of advertising and unhealthy food consumption to guide interested scholars and practitioners to shape the future research discourse.
Friend or Foe? A mixed method analysis of YouTube users’ replies to top comments of femvertising
Authors: Chen Huan , Feng Yang 
Published: November 2023

Purpose
This study aims to investigate replies to the top 10 comments under Always “Like a Girl” YouTube femvertising video to gauge consumers’ responses regarding femvertising as well as relationships among commenters.

Design/methodology/approach
This study adopted a mixed research methods design. A user analysis and a qualitative content analysis were conducted to examine the replies of the top 10 comments with the most replies to reveal not only the topics but also relationships and patterns among those comments and commenters.

Findings
The user analysis found that across all the 10 comment-and-reply units, in 8 units, the user of the original primary comment, the conversation starter, was also the user who was targeted most often. The qualitative content analysis revealed four themes from the 10 comment-and-reply units: multilayered emotional responses, a gendered society, complex coexisting relationships and a melting pot.

Research limitations/implications
The findings of this research offer significant extensions to the understanding of public sphere theory within the contemporary digital media landscape. By analyzing the nature of replies to digital advertisements, the study illuminates how various types of user engagement–whether it be inquiry, laudation, debate, or flame–play a critical role in shaping the digital public sphere.

Practical implications
The study underscores the importance for marketers to scrutinize both comments and replies to effectively utilize femvertising on social media, particularly YouTube. By understanding the emotional dynamics of user interactions, marketers can craft strategies that evoke positive responses and mitigate negative ones. Engaging with users who are open to changing their views or mediating discussions can also be beneficial, as can the use of AI tools to maintain focus on the content rather than on individual commenters. Such approaches can enhance the perception of femvertising campaigns and foster a more constructive dialogue within the social media space.

Originality/value
This study contributes to the literature by investigating the replies of comments, interactions, relationships and patterns among YouTube commenters that may generate valuable insights for advertisers and marketers to be aware of the possible issues and monitor the sentiment of commentaries, thus, developing effective strategies to better connect with consumers. This extends the understanding of public sphere theory in the contemporary digital media landscape.
Inter‐sectoral economic linkages in the Australian mining industry: Analysis using partial hypothetical extraction method
Authors: Weldegiorgis Fitsum S. , Dietsche Evelyn , Ahmad Shabbir , Franks Daniel M. , Cust James 
Published: November 2023

AbstractThe mining industry is not only one of Australia's main economic sectors but also one that the country is considered to have managed well. However, little is known about the industry's potential to contribute to the structural change of Australia's economy. We use the national input–output (IO) tables and apply the partial hypothetical extraction method (P‐HEM) within both the Leontief and Gosh IO frameworks to examine the inter‐sectoral linkages of the Australian mining and quarrying sector. Ee find that this sector demonstrates strong backward linkages (BL), but forward linkages (FL) appear to be weak, and they mainly involve non‐metallic materials. The mining and quarrying sector appears to generate linkages with the business services sector and the construction sector, which can potentially contribute to diversifying the economy. Such linkages may be realised via skilling and reallocating skilled labour and technical supplier capacity as well as via developing physical infrastructure that supports existing and new economic sectors. We find that the identified linkage pathways via the construction sector are tied to energy‐intensive but coal‐dependent sectors. Thus, these pathways are vulnerable because of the climate‐related need to move away from combusting coal and invest in cleaner sources of energy.
‘Real Orthodox men’: religious masculinities and the new Russian culture of military patriotism
Authors: Fomina Victoria 
Published: November 2023

AbstractThroughout the 1990s and early 2000s, radical nationalist and quasi‐fascist movements defining themselves in opposition to the Russian government dominated the country's paramilitary scene. This trend was almost completely reversed in the 2010s, with the relative decline of grassroots Slavic ethno‐nationalism and the emergence of a statist military‐patriotic culture centred on ‘traditional values’ and Orthodox faith. Drawing on field research with members of a Moscow‐based military‐patriotic club, this article shows how Orthodoxy emerged as an attractive ideological framework to give meaning to individual and communal practices of moral and physical self‐cultivation among patriotically oriented young middle‐class men. I argue that rather than a process of militarization of a religious public, the establishment of the Orthodox military‐patriotic milieu in the late 2000s is better understood as the Orthodoxization of the Russian paramilitary sphere, driven by young militaristically minded men's search for a sense of purpose and belonging. This post‐Soviet Orthodox paramilitary scene that combines militant masculinities with promotion of law abidance and civic values effectively works to curtail more extreme forms of ethno‐nationalism and thus invites us to rethink conventional wisdom on the relationship between religion, militarism, and violent radicalization.
Microscopical recognition and characterization of solution dyed fibers
Authors: Brinsko‐Beckert Kelly , Palenik Skip , Abraham Otyllia R. , Groves Ethan , Palenik Christopher S. 
Published: November 2023

AbstractSolution dyed fibers are synthetic fibers colored through the addition of insoluble pigmentation to the polymer prior to extrusion. This is in contrast to most textile fibers, which are traditionally colored via immersion in liquid dyebaths following extrusion. Solution dyed fibers are increasing in market share in numerous applications (e.g., apparel, carpet, upholstery), and thus, the microscopic characteristics and variety of pigments used to color them represent unexploited properties in forensic fiber comparisons. This paper presents the development of a microscopical process to first recognize a fiber as solution dyed and subsequently characterize the color and optical properties of each type of pigment found in a given fiber. To this end, a set of 76 fibers, representing polypropylene, nylon, polyester, and rayon, spanning all nominal colors and several consumer applications were analyzed longitudinally and in cross section using a combination of polarized light, fluorescence, and oil immersion microscopy. A given fiber contained between one and six different pigments, and a total of 260 pigments (not all unique) were recognized within this set of fibers. Pigment morphologies were categorized as angular, elongated, rounded, finely divided, or streaky, and about 40% of the pigments fluoresced. Ultimately, this body of data is intended to provide trace evidence examiners with a specific approach to recognize and begin to exploit pigmented fibers encountered in casework.
Streptomyces global regulators AfsR and AfsS interact to co‐regulate antibiotic production and morphological development
Authors: Hao Yi , Liu Wenshuai , Li Xingwang , Wen Ying 
Published: November 2023

AbstractStreptomyces species have a complex life cycle and are the producers of ~70% of commercial antibiotics. Global regulators AfsR and AfsS are widespread among Streptomyces and have been identified as key activators of antibiotic production in several species. However, their roles as repressors of antibiotic production are unclear; in particular, nothing is known regarding the regulatory mechanism of AfsS, despite many decades of research, because it has no DNA‐binding domain. Here, we demonstrate that AfsR and AfsS negatively regulate avermectin production and morphological development in the industrially important species S. avermitilis. AfsR directly represses ave structural genes (aveA1, aveA4), cluster‐situated activator gene aveR, and eight key developmental genes, whereas it directly activates afsS, aco (for autoregulator avenolide biosynthesis), and avaR1 (encoding avenolide receptor). GST pull‐down, microscale thermophoresis, co‐immunoprecipitation, and chromatin immunoprecipitation‐quantitative PCR assays demonstrated that AfsS interacts with AfsR to co‐regulate target genes involved in avermectin production and development and that this interaction requires intact AfsS repeated sequences and enhances the binding affinity of AfsR to target promoters. AfsR/AfsS interaction also occurs in model species S. coelicolor and S. roseosporus (producer of daptomycin, a cyclic lipopeptide antibiotic widely used for the treatment of human infections), suggesting that such interaction is conserved in Streptomyces species. The master developmental repressor BldD acts as a direct activator of both afsR and afsS. Deletion of afsR or afsS strongly enhances avermectin production in wild‐type and industrial S. avermitilis strains. Our findings demonstrate novel regulatory roles and mechanisms of AfsR and AfsS in Streptomyces and facilitate methods for antibiotic overproduction.
The new audit report with key audit matters: Lessons from Thailand's first implementation
Authors: Kitiwong Weerapong , Ekasingh Erboon , Sarapaivanich Naruanard 
Published: November 2023

AbstractUsing a mixed method research design, this study is the first to provide comprehensive evidence of the impacts of Thailand's first implementation of the new audit report with key audit matters (KAMs), which took place in 2016. Survey evidence shows that the new audit report improves the informative value and effectively narrows the deficient‐standards and deficient‐performance gaps. Nonetheless, financial statement users have made new demands for information that lie beyond auditors' traditional responsibility. Moreover, marginally significant evidence from archival data shows that although the disclosure of KAMs increases audit fees and audit delays, it improves audit quality. However, the market does not value KAMs.