bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desalination of seawater using integrated microbial biofilm/cellulose acetate membrane and silver NPs/activated carbon nanocomposite in a continuous mode
Authors: El Bestawy Ebtesam , El-Hameed Adel Salah Abd , Fadl Eman 
Published: January 2024

AbstractThe main objective of the present study was to desalinate seawater using Bacillus cereus gravel biofilm and cellulose acetate (CA) membranes with and without silver nanoparticles (AgNPs) as a potent and safe disinfectant for the treated water. Six desalination trials (I, II, III, IV, V and VI) were performed using the proposed biofilm/cellulose membrane. Results confirmed that Bacillus cereus gravel biofilm (microbial desalination) is the optimal system for desalination of seawater. It could achieve 45.0% RE (initial salinity: 44,478 mg/L), after only 3 h compared to the other tested treatments. It could also achieve 42, 42, 57, 43 and 59% RE for TDS, EC, TSS, COD and BOD, respectively. To overcome the problem of the residual salinity and reach complete elimination of salt content for potential reuse, multiple units of the proposed biofilm can be used in sequence. As a general conclusion, the Bacillus cereus biofilm system can be considered as remarkably efficient, feasible, rapid, clean, renewable, durable, environmentally friendly and easily applied technology compared to the very costly and complicated common desalination technologies. Up to our knowledge, this is the first time microbial biofilm was developed and used as an effective system for seawater desalination.
Modeling the compaction of bacterial chromosomes by biomolecular crowding and the cross-linking protein H-NS
Authors: Jung Youngkyun , Sadeghi Amir , Ha Bae-Yeun 
Published: January 2024

AbstractCells orchestrate the action of various molecules toward organizing their chromosomes. Using a coarse-grained computational model, we study the compaction of bacterial chromosomes by the cross-linking protein H-NS and cellular crowders. In this work, H-NS, modeled as a mobile “binder,” can bind to a chromosome-like polymer with a characteristic binding energy. The simulation results reported here clarify the relative role of biomolecular crowding and H-NS in condensing a bacterial chromosome in a quantitative manner. In particular, they shed light on the nature and degree of crowder and H-NS synergetics: while the presence of crowders enhances H-NS binding to a chromosome-like polymer, the presence of H-NS makes crowding effects more efficient, suggesting two-way synergetics in chain compaction. Also, the results show how crowding effects promote clustering of bound H-NS. For a sufficiently large concentration of H-NS, the cluster size increases with the volume fraction of crowders.
Effectiveness of a collagen matrix seal and xenograft in alveolar ridge preservation: an experimental study in dogs
Authors: Han Hee-seung , Lee Jung-Tae , Oh Seunghan , Cho Young-Dan , Kim Sungtae 
Published: January 2024

AbstractMajority of previous studies on alveolar ridge preservation (ARP) used collagen membranes as barrier membranes, and further evidence for ARP in dehiscent extraction sockets with a deproteinized bovine bone mineral (DBBM) and matrix is needed. The aim of this study is to assess the impact of non-cross linked collagen membranes (membrane) and crosslinked collagen matrices (matrix) on ARP using DBBM in extraction sockets with buccal dehiscence. In six mongrel dogs, the mesial roots of three mandibular premolars (P2, P3, and P4) were extracted 1 month after dehiscence defect induction. Two experimental groups were randomly assigned: (1) DBBM with a membrane (DBBM/membrane group) and (2) DBBM with a matrix (DBBM/matrix group). Three-dimensional (3D) volumetric, microcomputed tomography (μCT), and histologic analyses were performed to assess the ridge preservation. Both groups were effective to maintain the ridge width (p > 0.05), and the DBBM/matrix group showed more favorable soft tissue regeneration and bone quality in the histological analysis (p = 0.05). Based on these results, DBBM/matrix could be better choice for ARP in cases of buccal dehiscence defects.
Patient-related factors influencing the effectiveness and safety of Janus Kinase inhibitors in rheumatoid arthritis: a real-world study
Authors: Martinez-Molina Cristina , Gich Ignasi , Diaz-Torné Cesar , Park Hye S. , Feliu Anna , Vidal Silvia , Corominas Hèctor 
Published: January 2024

AbstractIn real-world scenarios, Janus Kinase (JAK) inhibitors are often offered to "difficult-to-treat" rheumatoid arthritis patients, quite different from those included in randomized controlled trials. Our study aimed to evaluate the influence of patient-related factors on the effectiveness and safety of JAK inhibitors in real-world clinical practice. This observational retrospective study involved rheumatoid arthritis patients who received treatment with either tofacitinib, baricitinib, upadacitinib, or filgotinib. At 12 months of treatment, reasons for and rates of JAK inhibitor treatment discontinuation were examined. Treatment retentions were analyzed through Cox proportional hazard regression models and Kaplan–Meier estimates. Patient-related factors that could influence treatment retention were evaluated for the discontinuation reasons of lack of effectiveness and adverse events. At 12 months of treatment, discontinuation rates for 189 JAK inhibitor treatments were: lack of effectiveness (24.3%), adverse events (20.6%), and other reasons (3.7%). The remaining 51.4% represents the treatment continuation rate. No patient-related factors evaluated had an influence on treatment discontinuation due to lack of effectiveness. Ae significantly increased the risk of treatment discontinuation due to adverse events (p = 0.030). In terms of age, at 12 month of treatment, discontinuation rates due to adverse events were: < 65 years, 14.4% vs. 65 years or older, 26.3% (p = 0.019). Rheumatoid arthritis patients aged 65 years or older showed an increased risk of JAK inhibitor treatment discontinuation due to adverse events. Factors not related to treatment discontinuation were: sex, rheumatoid arthritis disease duration, rheumatoid arthritis disease activity, seropositivity for rheumatoid factor, seropositivity for anti-cyclic citrullinated peptides, number of prior biologic treatments, number of prior JAK inhibitor treatments, concomitant use of glucocorticoids, and concomitant use of conventional synthetic disease-modifying antirheumatic drugs.
Changes in the equine facial repertoire during different orthopedic pain intensities
Authors: Ask Katrina , Rhodin Marie , Rashid-Engström Maheen , Hernlund Elin , Andersen Pia Haubro 
Published: January 2024

AbstractA number of facial expressions are associated with pain in horses, however, the entire display of facial activities during orthopedic pain have yet to be described. The aim of the present study was to exhaustively map changes in facial activities in eight resting horses during a progression from sound to mild and moderate degree of orthopedic pain, induced by lipopolysaccharides (LPS) administered in the tarsocrural joint. Lameness progression and regression was measured by objective gait analysis during movement, and facial activities were described by EquiFACS in video sequences (n = 348, total length 892.5 min) of the horses obtained when resting in their box stalls. Predictive modeling identified 16 action units and action descriptors, related to ears, eyes, and lower face. Lower lip depressor (AU16), lips part (AU25), half blink (AU47), single ear forward (SEAD101) and single ear rotator (SEAD104) were selected as co-occurring significantly more in horses with pain than in horses without pain. The major change in co-occurring facial activities occurred in the transition from no pain to mild pain. In conclusion, resting horses with induced orthopedic pain showed a dynamic upper and lower facial repertoire and the relationship between level of pain intensity and facial activity appears complex.
Identification of potential diagnostic biomarkers associated with periodontitis by comprehensive bioinformatics analysis
Authors: Gao Sixue , Lin Meina , Chen Wei , Chen Xinren , Tian Zhiying , Jia Tong , Xue Yang , Song Jie , Lu Yongping , Zhou Linxi , Wu Liuzhong 
Published: January 2024

AbstractPeriodontitis is a chronic inflammatory disease that affects the tissues surrounding the teeth, including the gums and the bones supporting the teeth. Early detection and intervention are crucial for effective management of periodontitis. Our study aims to identify a diagnostic biomarker for periodontitis and explore the pathways associated with the occurrence and development of periodontitis. The expression of gingival tissue from periodontitis and healthy control were downloaded from the Gene Expression Omnibus. The weighted gene co-expression network analysis (WGCNA) were used to analyze module genes associated with periodontitis and DESeq2 were performed to identify differently expressed genes (DEGs) between periodontitis and healthy control. Then the candidate genes were obtained by intersecting the genes from interest modules and DEGs. Functional enrichment analysis was performed using gene ontology and kyoto encyclopedia of gene and genomes, followed by the protein–protein interaction (PPI) network analysis. The hub genes were identified by the cytoCNA plugin in Cytoscape. Finally, immunohistochemical staining of the hub genes was performed to validate the findings. WGCNA analysis found that the expression of the MEblack module was significantly higher in individuals with periodontitis compared to those in the healthy control group. A total of 888 DEGs, including 750 upregulated and 138 downregulated genes, were identified. Finally, 427 candidate genes were identified potentially associated with periodontitis after intersecting the DEGs and the black module genes. Several critical signaling pathways were identified associated with periodontitis by functional enrichment analysis, including cytokine–cytokine receptor interaction, neutrophil extracellular trap formation, Staphylococcus aureus infection, and Interleukin-17 signaling pathway. The PPI network analysis revealed that C-X-C motif chemokine ligand 5 (CXCL5) and C-X-C motif chemokine ligand 6 (CXCL6) could play an important role in the process of periodontitis. The gene expression level of CXCL5 and CXCL6 detected using immunohistochemical verified the findings. In conclusion, we found that CXCL5 and CXCL6 are closely associated with the occurrence of periodontitis. Our present pilot study suggests that CXCL5 and CXCL6 have the potential to be used as a diagnostic biomarker of periodontitis.
Biomarker and isotopic characteristics of Miocene condensates and natural gases, West Delta deep marine concession, Eastern Mediterranean, Egypt
Authors: Lotfy Naira M. , Farouk Sherif , Hakimi Mohammed Hail , Ahmad Fayez , El Shennawy Tamer , El Nady Mohamed M. , Salama Ahmad , Shehata Amr M. 
Published: January 2024

AbstractThe Western Delta Deep Marine Concession (WDDM) in the Eastern Mediterranean Sea is one of northern Africa's most recent petroleum-potential regions for gas and condensate exploration. The present study aims to determine the characteristics of the 15 natural gases and 5 associated condensate samples, using molecular compositions and isotopes from the Miocene reservoir rocks in the various wells located in the WDDM. The results of this study are also used to determine the gas-condensate correlation for their probable source rocks as well as the methane-generating mechanisms (i.e., thermogenic or microbiological). Results highlighted in this research reveal that most of the natural gases in WDDM are mainly thermogenic methane gases, with small contributions of biogenic methane gases that were generated from mainly mixed sources, with a high sapropelic organic matter input for biogenic gases. The thermogenic methane gases were formed from secondary oil and oil/gas cracking at the high maturity stage of the gas window. The biogenic gases are also contributed to the Miocene reservoirs, which are formed from the primary cracking of kerogen at low maturity stage by the action of CO2 bacterial reduction. In addition, the saturated and aromatic biomarker results show that the condensate samples were generated from clay-rich source rocks. This source unit of the Miocene condensates were deposited in a fluvial deltaic environmental setting, containing mixed kerogen type II/III and accumulated during the Jurassic–Cretaceous, as evidenced by the age dating indicators. The properties of the natural gases and associated condensates in the Miocene reservoir rocks suggest that most of the thermogenic methane gases, together with the condensate, are derived primarily from mature Jurassic–Cretaceous source rocks and formed by secondary oil and oil/gas cracking at the gas generation window, as demonstrated by the 1-D basin modelling results highlighted in the prior works. Therefore, most of the natural gases in WDDM are non-indigenous and migrated from more mature Jurassic–Cretaceous source rocks in the nearby Northern Sinai provinces or the deeper sequences in the offshore Nile Delta provinces.
Research on the interaction between energy consumption and power battery life during electric vehicle acceleration
Authors: Liu Qin , Zhang Zhongbo , Zhang Jingjing 
Published: January 2024

AbstractMost studies on the acceleration process of electric vehicle focus on reducing energy consumption, but do not consider the impact of the power battery discharge current and its change rate on the battery life. Therefore, this paper studied the interaction between electric vehicle energy consumption and power battery capacity attenuation during acceleration. First, a power battery life model for electric vehicle under driving conditions is established, and the percentage of battery capacity loss per kilometer is used to measure the capacity loss under different acceleration conditions. Then, the relationship between the percentage of battery capacity loss per kilometer and velocity and acceleration is explored, and the capacity attenuation mechanism of power battery under different acceleration processes is analyzed. Finally, the energy consumption and battery capacity attenuation is studied when the electric vehicle accelerated with multiple accelerations curves, and the interaction of the first acceleration and acceleration time on the electric vehicle energy consumption and the power battery capacity attenuation characteristics is discussed. The research results indicate that when the electric vehicle accelerates with different multiple accelerations curves, the change of energy consumption per kilometer and percentage of battery capacity loss per kilometer with acceleration and acceleration time is different, and the change of the two is basically opposite.
A randomized double-blind placebo-controlled trial of an inhibitor of plasminogen activator inhibitor-1 (TM5614) in mild to moderate COVID-19
Authors: Hirai Toyohiro , Asano Koichiro , Ito Isao , Miyazaki Yasunari , Sugiura Hisatoshi , Agirbasli Mehmet , Kobayashi Seiichi , Kobayashi Makoto , Shimada Daishi , Natsume Ichiro , Kawasaki Tsutomu , Ohba Takehiko , Tajiri Sakurako , Sakamaki Fumio , Mineshita Masamichi , Takihara Takahisa , Sekiya Kiyoshi , Tomii Keisuke , Tomioka Hiromi , Kita Hideo , Nishizaka Yasuo , Fukui Motonari , Miyata Toshio , Harigae Hideo 
Published: January 2024

AbstractAn inhibitor of plasminogen activator inhibitor (PAI)-1, TM5614, inhibited thrombosis, inflammation, and fibrosis in several experimental mouse models. To evaluate the efficacy and safety of TM5614 in human COVID-19 pneumonia, phase IIa and IIb trials were conducted. In an open-label, single-arm trial, 26 Japanese COVID-19 patients with mild to moderate pneumonia were treated with 120–180 mg of TM5614 daily, and all were discharged without any notable side effects. Then, a randomized, double-blind, placebo-controlled trial was conducted in Japanese COVID-19 patients with mild to moderate pneumonia. The number of study participants was set to be 50 in each arm. Even after extension of the enrollment period, the number of study participants did not reach the initially intended sample size, and 75 patients were enrolled in the study. The total oxygenation scale from Day 1 to Day 14 as the primary endpoint was 1.5 in the TM5614 group vs 4.0 in the placebo group (p = 0.22), and the number of days of oxygen administration required as the secondary endpoint was 2.0 days in the TM5614 group vs 3.5 days in the placebo group (p = 0.34). Further studies will be necessary to verify the efficacy of PAI-1 inhibition for the treatment of COVID-19 pneumonia.Clinical trial registration: Two studies were conducted: a prospective, multicenter, open-label phase II study at https://jrct.niph.go.jp (jRCT2021200018) (First registration date 18/08/2020) and a prospective, multicenter, randomized, double-blind, placebo-controlled, phase II study at https://jrct.niph.go.jp (jRCT2021210006) (First registration date 28/05/2021).
Dual-band 5G MIMO antenna with enhanced coupling reduction using metamaterials
Authors: Khan Daud , Ahmad Ashfaq , Choi Dong-You 
Published: January 2024

AbstractThis article introduces a miniaturized dual-band multiple input multiple output (MIMO) antenna with wide bandwidth and high isolation. The design incorporates ground plane modifications and utilizes metamaterials to achieve dual-band operation in the millimeter wave spectrum for 5G applications, specifically operating at the 28/38 GHz frequency bands. The proposed antenna maintains its dual-band functionality despite its compact size of 3.8 $$\times$$
×
3.7 $$\times$$
×
0.787 $$\text {mm}^3$$

mm
3

(without the feed line). The antenna is fabricated on a Rogers RT5880 substrate with a thickness of 0.787 mm and with relative permittivity $$\varepsilon _r$$

ε
r

= 2.2. The MIMO system comprises two symmetric radiating elements positioned in close proximity, resulting in mutual coupling levels of $$-$$
-
20 dB and $$-$$
-
12 dB at 25 GHz and 37 GHz, respectively. Modifications are made to the ground length to enhance the isolation at the higher frequency band while embedding metamaterials effectively reduces the coupling at the lower frequency band. The incorporation of metamaterials leads to an enhanced bandwidth from 3.8 to 4.8 GHz in the desired lower band (24–28.8 GHz) and from 3.8 to 4.2 GHz in the higher band (36.6–40.8 GHz). The proposed system can operate across the 28/38 GHz bands using a compact design, thus offering reasonable isolation, an envelope correlation coefficient below 0.0001, and a significant diversity gain (> 9.99 dB). These attributes emphasize the system’s suitability for 5G millimeter-wave cellular communications.
Spatio-temporal interactions between the red fox and the wolf in two contrasting European landscapes
Authors: Lazzeri Lorenzo , Ferretti F. , Churski M. , Diserens T. A. , Oliveira R. , Schmidt K. , Kuijper D. P. J. 
Published: January 2024

AbstractRelationships among carnivore species are complex, potentially switching from competition to facilitation on a context-dependent basis. Negative associations are predicted to increase with latitude, due to limited resources emphasising competition and/or intra-guild predation. Accordingly, a stronger negative correlation between large- and meso-carnivore abundances should be expected at higher latitudes, with a substantial spatio-temporal partitioning favouring interspecific coexistence. Human presence may influence spatio-temporal relationships between (meso)carnivore species, as it can be perceived as a risk factor, but anthropogenic food can also provide an important additional food resource. Using camera-trap data, we studied the spatio-temporal associations between two of the most widespread carnivores in Europe, i.e., the red fox and wolf. We compared their monthly/daily spatio-temporal partitioning between two different landscapes: Białowieża Primeval Forest (Poland) and the Mediterranean Maremma Regional Park (Italy). We predicted a stronger interspecific partitioning, as well as more attraction of red foxes to humans in the northern site (Poland). Temporal activity patterns of the two carnivores overlapped in both sites, and their detection rates were positively associated, even though in weaker way in Poland. We observed a positive spatial association of red foxes with human activity in Białowieża, but not in Maremma. This association occurred only at a monthly temporal scale and disappeared at a daily scale, suggesting some disturbance in the shorter term. Our results provided partial support to our predictions and suggest that, despite the ecological differences between our study areas, only weak differences in wolf-fox relations were observed, suggesting that red fox responses to wolves may be relatively comparable over large spatial scales.
A Mendelian randomization study on the effects of plasma lipids on irritable bowel syndrome and functional dyspepsia
Authors: Xu Mengmeng , Liu Deliang , Tan Yuyong , He Jian , Zhou Bingyi 
Published: January 2024

AbstractAlthough functional gastrointestinal disorder (FGID) is a common clinical condition, its risk factors remain unclear. We performed a Mendelian randomization study to explore the association between plasma lipids and the risk of FGID. Instrumental variables closely related to six plasma lipids were obtained from the corresponding genome-wide association studies, and summary-level data on FGID, including irritable bowel syndrome (IBS) and functional dyspepsia (FD), were extracted from the FinnGen study. The primary inverse variance weighted method and other supplementary analyses were used to evaluate the causal relationship between diverse plasma lipids and FGID. For each increase in the standard deviation of triglyceride levels, there was a 12.0% increase in the risk of IBS rather than that of FD. Low- and high-density lipoprotein cholesterol, total cholesterol, apolipoprotein A, and apolipoprotein B levels were not associated with the risk of IBS or FD. Through this study, we identified the causal role of triglycerides in the pathogenesis of IBS, which could benefit further basic and clinical research.
Phase coexistence in the fully heterogeneous Hegselmann–Krause opinion dynamics model
Authors: Perrier Rémi , Schawe Hendrik , Hernández Laura 
Published: January 2024

AbstractWe present an extensive study of the joint effects of heterogeneous social agents and their heterogeneous social links in a bounded confidence opinion dynamics model. The full phase diagram of the model is explored for two different network’s topologies and compared to two opposed extreme cases: on one hand, the heterogeneous agents constitute a mixed population and on the other, their interactions are modeled by a lattice. The results show that when agents prone to compromise coexist with close-minded ones, the steady state of the dynamics shows coexistent phases. In particular, unlike the case of homogeneous agents in networks, or heterogeneous agents in a fully mixed population, it is possible that the society ends up in consensus around one extreme opinion. Moreover, during the dynamics, the consensus may be overturned from one extreme to the other of the opinion space. We also show that the standard order parameter, the normalized average size of the largest opinion cluster, may be misleading in this case, as it hides the existence of these phases. The phase where the opinion of the society is overturned does not require the presence of agents with special characteristics, (stubborn, extremists, etc.); it results from the interplay of agents which have agreed on an extreme opinion with the remaining group that holds the opposite one. Among the former, some may be prone to compromise with other agents which are out of the majority group, these agents, according to their location in the network, may act like bridges between the two groups and slowly attract the whole society to the other extreme.