bluuebunny/crossref_metadata_2025_split huggingface dataset:
The synergistic role of virtual coaching with simulation‐based mastery learning for upper endoscopy
Authors: Nguyen‐Vu Tiffany , Chin YungKa , Malvar Carmel , Cabral‐Prodigalidad Patricia Anne , De Lusong Mark , Maulahela Hasan , Mekaroonkamol Parit , Ong Andrew , Djajakusuma Angela , Myint Thomas , Nurmalihah Hilda , Asokkumar Ravishankar , Francisco Carlos , Liu Jesse , Rerknimitr Rungsun , Shergill Amandeep , Sanduleanu Silvia , Kaltenbach Tonya , Soetikno Roy 
Published: January 2024

AbstractIntroductionOur simulation‐based mastery learning (SBML) curriculum, delivered in person, has been shown to successfully train novices in structured esophagogastroduodenoscopy (EGD). SBML with virtual coaching (VC) has the potential to improve the effectiveness and efficiency of endoscopy training and expand access to trainees from around the world. We share our observations conducting an EGD training course using SBML with VC.MethodsWe conducted a 1‐week virtual SBML course for novice trainees across seven academic centers in the USA and Asia. The cognitive component was delivered using an online learning platform. For technical skills, a virtual coach supervised hands‐on training and local coaches provided assistance when needed. At the end of training, an independent rater assessed simulation‐based performance using a validated assessment tool. We assessed the clinical performance of 30 EGDs using the ASGE Assessment of Competency in Endoscopy tool. We compared the trainees’ scores to our cohort trained using in‐person SBML training using non‐inferiority t‐tests.ResultsWe enrolled 21 novice trainees (mean age: 30.8 ± 3.6 years; female: 52%). For tip deflection, the trainees reached the minimum passing standard after 31 ± 29 runs and mastery after 52 ± 37 runs. For structured EGD, the average score for the overall exam was 4.6 ± 0.6, similar to the in‐person cohort (4.7 ± 0.5, p = 0.49). The knowledge‐based assessment was also comparable (virtual coaching: 81.9 ± 0.1; direct coaching: 78.3 ± 0.1; p = 0.385). Over time, our novice trainees reached clinical competence at a similar rate to our historical in‐person control.ConclusionsVC appears feasible and effective for training novice gastroenterology trainees. VC allowed us to scale our SBML course, expand access to experts, and administer SBML simultaneously across different sites at the highest standards.
Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis
Authors: Hulscher Nicolas , Hodkinson Roger , Makis William , McCullough Peter A. 
Published: January 2024

AbstractCOVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis. We performed a systematic review of all published autopsy reports involving COVID‐19 vaccination‐induced myocarditis through 3 July 2023. All autopsy studies that include COVID‐19 vaccine‐induced myocarditis as a possible cause of death were included. Causality in each case was assessed by three independent physicians with cardiac pathology experience and expertise. We initially identified 1691 studies and, after screening for our inclusion criteria, included 14 papers that contained 28 autopsy cases. The cardiovascular system was the only organ system affected in 26 cases. In two cases, myocarditis was characterized as a consequence from multisystem inflammatory syndrome. The mean age of death was 44.4 years old. The mean and median number of days from last COVID‐19 vaccination until death were 6.2 and 3 days, respectively. We established that all 28 deaths were most likely causally linked to COVID‐19 vaccination by independent review of the clinical information presented in each paper. The temporal relationship, internal and external consistency seen among cases in this review with known COVID‐19 vaccine‐induced myocarditis, its pathobiological mechanisms, and related excess death, complemented with autopsy confirmation, independent adjudication, and application of the Bradford Hill criteria to the overall epidemiology of vaccine myocarditis, suggests that there is a high likelihood of a causal link between COVID‐19 vaccines and death from myocarditis.
Inflation forecasting with rolling windows: An appraisal
Authors: Hall Stephen G. , Tavlas George S. , Wang Yongli , Gefang Deborah 
Published: January 2024

AbstractWe examine the performance of rolling windows procedures in forecasting inflation. We implement rolling windows augmented Dickey–Fuller (ADF) tests and then conduct a set of Monte Carlo experiments under stylized forms of structural breaks. We find that as long as the nature of inflation is either stationary or non‐stationary, popular varying‐length window techniques provide little advantage in forecasting over a conventional fixed‐length window approach. However, we also find that varying‐length window techniques tend to outperform the fixed‐length window method under conditions involving a change in the inflation process from stationary to non‐stationary, and vice versa. Finally, we investigate methods that can provide early warnings of structural breaks, a situation for which the available rolling windows procedures are not well suited.
Can night trading reduce price volatility? Evidence from China's corn and corn starch futures markets
Authors: Xia Weiyi , Xiong Tao , Li Miao 
Published: January 2024

AbstractSince 2013, China's futures exchanges have implemented night trading for agricultural futures to reduce the overnight risk and price jump of futures products by extending trading hours. This study uses difference‐in‐differences (DID) to examine the impacts of night trading on daytime price volatility in corn and corn starch futures markets. On the basis of tick‐by‐tick data for these futures, we find that night trading has significantly reduced daytime volatility and contributed to price volatility stability in the corresponding futures market. Moreover, we make DID estimations for separate daytime sessions and find that the reduction of the daytime volatility takes place mainly during the first trading session. Robustness and placebo tests further support our main conclusions. Our results provide valuable guidance for futures exchanges and regulators seeking to formulate night trading policies for futures and options.
Transoral robotic vertical partial laryngectomy (hemilaryngectomy) extended to the hypopharynx
Authors: Meliante Piero Giuseppe , Battilocchi Ludovica , Costantino Andrea , Lee Kyuin , Moon Seo Jin , Ralli Massimo , Minni Antonio , Capaccio Pasquale , Pignataro Lorenzo , de Vincentiis Marco , Kim Se‐Heon 
Published: January 2024

AbstractLocally advanced laryngeal cancers treatment often involves total laryngectomy, which some patients are unwilling to undergo, even if this choice reduces their survival probability. Therefore, the objective of laryngeal oncologic surgery is not only to remove the tumor, but also to preserve the organ and its functions. To overcome these concerns, several partial laryngectomy techniques have been developed. This article describes the surgical technique and a case study of a 64‐year‐old male patient with locally advanced laryngeal squamous cell carcinoma who underwent vertical partial laryngectomy extending to the subglottis and hypopharynx using transoral robotic surgery (TORS) with a da Vinci Single Port surgical robot. The video and article provide a detailed description of the surgical technique, which resulted in successful tumor removal with excellent oncological and functional outcomes.
Heat transfer characteristics of thermo‐diffusion (Soret) and diffusion‐thermo (Dufour) effects in a square cavity containing a non‐Darcy porous medium
Authors: Krishnamoorthy Seenuvasan , Ramachandra Prasad Vallampati 
Published: January 2024

AbstractThe impact of the double‐diffusive natural convection of water in a square enclosure with diffusion‐thermo and thermo‐diffusion around the non‐Darcy porous medium is studied numerically. The top and bottom side walls of the cavity are maintained at constant temperatures, while the vertical left and right walls are considered to be cold. Water is considered the working fluid. The resulting nondimensional partial differential equation is solved by the Marker and Cell (MAC) method by using a staggered grid system. The Dufour and Soret effects processes will be a significantly essential role in the double‐diffusive velocity flow processes. For different values of the relevant parameters, the fluid flow velocity, temperature, and concentration are presented for various Rayleigh numbers, Prandtl numbers, non‐Darcy, thermo‐diffusion, and diffusion‐thermo. The streamlines, isotherms, and iso‐concentration contours are obtained using the MATLAB software. Finally, it is observed that the Nusselt numbers increased with non‐Darcy, thermo‐diffusion, and Rayleigh numbers and decreased with diffusion‐thermo effects.
Monitoring of optical properties of tumors during laser plasmon photothermal therapy
Authors: Genin Vadim D. , Bucharskaya Alla B. , Kirillin Mikhail Yu. , Kurakina Daria A. , Navolokin Nikita A. , Terentyuk Georgy S. , Khlebtsov Boris N. , Khlebtsov Nikolai G. , Maslyakova Galina N. , Tuchin Valery V. , Genina Elina A. 
Published: January 2024

AbstractWe studied grafted tumors obtained by subcutaneous implantation of kidney cancer cells into male white rats. Gold nanorods with a plasmon resonance of about 800 nm were injected intratumorally for photothermal heating. Experimental irradiation of tumors was carried out percutaneously using a near‐infrared diode laser. Changes in the optical properties of the studied tissues in the spectral range 350–2200 nm under plasmonic photothermal therapy (PPT) were studied. Analysis of the observed changes in the absorption bands of water and hemoglobin made it possible to estimate the depth of thermal damage to the tumor. A significant decrease in absorption peaks was observed in the spectrum of the upper peripheral part and especially the tumor capsule. The obtained changes in the optical properties of tissues under laser irradiation can be used to optimize laboratory and clinical PPT procedures.
Theoretical insights into photoinduced excited‐state behaviors for the novel CHPPhl fluorophore: Effects of solvent polarity
Authors: Li Chaozheng , Hou Mengmeng , Dong Hao , Liu Rivaille 
Published: January 2024

AbstractInspired by the distinguished photochemical and photophysical properties of novel hydroxyl‐substituted tetraphenylimidazole (HPI) derivatives that could be potentially applied across various disciplines, in this work, effects of solvent polarity on excited‐state hydrogen bond effects and excited‐state intramolecular proton transfer (ESIPT) reaction of 3‐(6,9‐Diphenyl‐1H‐phenanthro[9,10‐d]imidazole‐2‐yl)‐9‐phenyl‐9H‐carbazol‐4‐ol (CHPPhl) are focused. By comparing the structural changes and infrared (IR) vibrational spectra of the E‐HBT fluorophore in polar acetone, moderate polar tetrahydrofuran and non‐polar hexane solvents, combined with the preliminary detection of hydrogen bond interaction by core–valence bifurcation (CVB) index, we can conclude that the hydrogen bond could be strengthened in S1 state, which is favorable for the occurrence of ESIPT reactions. The charge recombination behavior of hydrogen bond induced by photoexcitation also further illustrates this point. Via constructing potential energy curves (PECs) based on restrictive optimization and searching transition state (TS) form, we confirm change of surrounding solvent polarity has a regulatory effect on the ESIPT behavior for CHPPhl; that is, the lower the solvent polarity is more conducive to the ESIPT reaction.
Analysis of extracellular vesicle microRNA profiles reveals distinct blood and lymphatic endothelial cell origins
Authors: Pultar Marianne , Oesterreicher Johannes , Hartmann Jaana , Weigl Moritz , Diendorfer Andreas , Schimek Katharina , Schädl Barbara , Heuser Thomas , Brandstetter Marlene , Grillari Johannes , Sykacek Peter , Hackl Matthias , Holnthoner Wolfgang 
Published: January 2024

AbstractExtracellular vesicles (EVs) are crucial mediators of cell‐to‐cell communication in physiological and pathological conditions. Specifically, EVs released from the vasculature into blood were found to be quantitatively and qualitatively different in diseases compared to healthy states. However, our understanding of EVs derived from the lymphatic system is still scarce. In this study, we compared the mRNA and microRNA (miRNA) expression in blood vascular (BEC) and lymphatic (LEC) endothelial cells. After characterization of the EVs by fluorescence‐triggered flow cytometry, nanoparticle tracking analysis and cryo‐transmission electron microscopy (cryo‐TEM) we utilized small RNA‐sequencing to characterize miRNA signatures in the EVs and identify cell‐type specific miRNAs in BEC and LEC. We found miRNAs specifically enriched in BEC and LEC on the cellular as well as the extracellular vesicle level. Our data provide a solid basis for further functional in vitro and in vivo studies addressing the role of EVs in the blood and lymphatic vasculature.
miR‐451a suppresses the proliferation and migration of high‐grade serous ovarian cancer by targeting RAB5A through the Ras/Raf/MEK/ERK pathway
Authors: Liu Shujie , Wang Kun , Zhao Zhendan , Pang Yu , Liu Fang , Wang Pengling , Wang Zhiling , Yang Xingsheng 
Published: January 2024

AbstractBackgroundOvarian cancer is one of the most common cancers in women. Profiles changes of microRNAs (miRNAs) are closely linked to malignant tumors. In the present study, we investigated expression of miR‐451a in high‐grade serous ovarian cancer (HGSOC). We also investigated the potential pathological roles and the likely mechanism of miR‐451a in the development of HGSOC using animal models and cell lines.MethodsUsing bioinformatics techniques and a real‐time PCR, we analyzed differently expressed miRNAs in HGSOC compared to normal tissue. MTT (i.e. 3‐[4, 5‐dimethyl thiazol‐2‐yl]‐2,5‐diphenyl tetrazolium bromide), EDU (i.e. 5‐ethynyl‐2′‐deoxyuridine) and transwell assays were performed to investigate the effect of miR‐451a on the proliferation and migration of HGSOC SKOV‐3 cells. A dual luciferase reporter assay was performed to verify the targeting relationship of miR‐451 and RAB5A (one of the Rab GTPase proteins that regulates endocytosis and vesicle transport). Also, we analyzed levels of the RAB5A mRNA and protein by real‐time PCR, western blotting and immunohistochemistry assays in HGSOC cells and tissues. Finally, we performed in vivo experiments using HGSOC mice.ResultsmiR‐451a was substantially upregulated in HGSOC and associated with favorable clinical characteristics. miR‐451a knockdown significantly increased growth and metastasis of HGSOC cell line SKOV‐3 through Ras/Raf/mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK) signaling. In addition, RAB5A, an early endosome marker, was shown to be a direct target of miR‐451a. Moreover, RAB5A is correlated with unfavorable clinical features and shows independent prognostic significance in HGSOC.ConclusionsWe found that the miR‐451a/RAB5A axis is associated with tumorigenesis and progression through the Ras/Raf/MEK/ERK pathway, providing prognostic indicators and therapeutic targets for patients with HGSOC.
Impact of bare fallow management on soil carbon storage and aggregates across a rock fragment gradient
Authors: Schweizer Steffen A. , Aehnelt Michaela , Bucka Franziska , Totsche Kai Uwe , Kögel‐Knabner Ingrid 
Published: January 2024

AbstractBackgroundOur understanding of C storage in soils lacks insights investigating organic matter (OM) depletion, often studied in bare fallow systems. The content of coarse rock fragments is often excluded, whereas it may affect C storage.AimsWe aim to contribute to a better understanding of the impact of bare fallow on C storage mechanisms in the soil as influenced by its coarse rock fragment contents. We investigated whether bare fallow induced a depletion of C in OM fractions and analyzed to which extent this affected soil aggregate size distribution and the C loading of the clay‐sized fraction.MethodsA comparison of 14 years bare fallow management with adjacent cropped soils located in Selhausen (Germany) provided a gradient of coarse rock fragments of 34%–71%, from which sites with three different fine earth (FE) contents were compared. Across the FE gradient, we isolated particulate OM and mineral‐associated OM fractions, obtained microaggregate and macroaggregate size fractions, and quantified the C loading.ResultsBare fallow management induced an OM depletion at lower contents of FE. There, the management influence was more concentrated onto less FE volume. The contribution of both particulate and mineral‐associated OM fractions to the C in the low‐FE soils decreased. The C loading increased under bare fallow, compared to cropped soil. In the low‐FE soil, we also found less macroaggregates, whereas the C content decreased in some microaggregate size fractions.ConclusionsA high content of coarse rock fragments can enhance OM depletion decreasing mineral‐associated and particulate C under bare fallow.
Tolerance development in cow's milk‐allergic children receiving amino acid‐based formula with synbiotics: 36‐Months follow‐up of a randomized controlled trial (PRESTO Study)
Authors: Chatchatee Pantipa , Nowak‐Wegrzyn Anna , Lange Lars , Benjaponpitak Suwat , Chong Kok W. , Sangsupawanich Pasuree , Eussen Simone R. B. M. , van Ampting Marleen T. J. , Oude Nijhuis Manon M. , Langford Jane E. , Trendelenburg Valerie , Pesek Robert , Davis Carla M. , Muraro Antonella , Erlewyn‐Lajeunesse Michel , Fox Adam T. , Michaelis Louise J. , Beyer Kirsten ,   PRESTO study team
Published: January 2024

AbstractThe objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid‐based formula with synbiotics (AAF‐S) or amino acid‐based formula without synbiotics (AAF) during a 1‐year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.8 ± 0.27 years) who developed CM tolerance after 36 months was similar in the group receiving AAF‐S (47/60 [78%]) and in the group receiving AAF (49/66 [74%]) (p = 0.253), that is, figures comparable to natural outgrowth of CM allergy. Our data suggest that the consumption of AAF and absence of exposure to CM peptides do not slow down CM tolerance acquisition.
Identification and molecular docking of tyrosinase inhibitory peptides from allophycocyanin in Spirulina platensis
Authors: Yu Zhipeng , Lv Hong , Zhou Mingjie , Fu Pengcheng , Zhao Wenzhu 
Published: January 2024

AbstractBACKGROUNDTyrosinase, a copper‐containing metalloenzyme with catalytic activity, is widely found in mammals. It is the key rate‐limiting enzyme that catalyzes melanin synthesis. For humans, tyrosinase is beneficial to the darkening of eyes and hair. However, excessive deposition of melanin in the skin can lead to dull skin color and lead to pigmentation. Therefore, many skin‐whitening compounds have been developed to decrease tyrosinase activity. This study aimed to identify a new tyrosinase inhibitory peptide through enzymatic hydrolysis, in vitro activity verification, molecular docking, and molecular dynamics (MD) simulation.RESULTSA tripeptide Asp‐Glu‐Arg (DER) was identified, with a ‘‐CDOCKER_Energy’ value of 121.26 Kcal mol−1. DER has effective tyrosinase inhibitory activity. Research shows that its half maximal inhibitory concentration value is 1.04 ± 0.01 mmol L−1. In addition, DER binds to tyrosinase residues His85, His244, His259, and Asn260, which are key residues that drive the interaction between the peptide and tyrosinase. Finally, through MD simulation, the conformational changes and structural stability of the complexes were further explored to verify and supplement the results of molecular docking.CONCLUSIONThis experiment shows that DER can effectively inhibit tyrosinase activity. His244, His259, His260, and Asn260 are the critical residues that drive the interaction between the peptide and tyrosinase, and hydrogen bonding is an important force. DER from Spirulina has the potential to develop functional products with tyrosinase inhibition. © 2024 Society of Chemical Industry.
To study the survival analysis and recurrence pattern in women treated for breast cancer: Retrospective study, a tertiary cancer center experience from Sub‐Himalayan Region of India
Authors: Sundram Shivangi , Nandi Sourabh , Arora Anshika , Saini Sunil 
Published: January 2024

AbstractBackgroundBreast cancer is a leading health concern in India, comprising 25% of female cancers with significant mortality. This study was conducted at the Cancer Research Institute in the Northern Sub‐Himalayan region of India from 2016 to 2021, evaluated 674 breast cancer cases to analyze factors that influence recurrence.MethodologyRetrospective clinical audit assessing patients’ survival outcomes using Kaplan–Meier curves and Cox proportional hazard regression. Factors including age, molecular subtype, TNM staging, and treatment modalities were evaluated.ResultsNotable findings include a high occurrence of breast cancer in young patients (24.48% ≤ 40 years) and varying recurrence rates among molecular subtypes with human epidermal growth factor receptor 2 neu‐enriched (25.24%) and triple‑negative breast cancer (22.58%) being the most common. Advanced T and N stages, neoadjuvant chemotherapy, and the number of nodes dissected showed significant associations with higher recurrence rates.ConclusionThis study sheds light on survival and recurrence patterns in Northern Sub‐Himalayan breast cancer patients, emphasizing the need for tailored treatment strategies, comprehensive follow‐up care, with improved understanding of regional outcomes. These findings contribute valuable insights for optimizing patient care and improving survival rates in this region.
Impact of travelers' consumer ethnocentrism on purchase and behavior intention: moderating effect of implicit prejudice
Authors: Kim Haeok Liz , Hyun Sunghyup Sean 
Published: January 2024

AbstractThis study investigated the effects of rigid thinking, ideology, and explicit and implicit prejudices on consumer ethnocentrism. Explicit and implicit prejudices significantly affected consumer ethnocentrism, but not travel behavioral intention. Among the three variances—Asian–European American, skin tone, and Arab‐Muslim Implicit Association Test (IAT)—used as implicit prejudice control variables, only implicit prejudice regarding Arab‐Muslim names significantly affected travel product purchase intention and travel behavior. The results revealed that consumers with strong consumer ethnocentrism are likely to avoid purchasing overseas travel products. These findings suggest the introduction of customized tourism marketing methods in countries with strong ethnocentrism.
Characteristics of market segmentation for sustainable medical tourism
Authors: Cha Jaebin , Jo Mina , Lee Timothy J. , Hyun Sunghyup Sean 
Published: January 2024

AbstractThis study investigated the characteristics of markets segmented by the push–pull factors associated with medical tourists. The questionnaire sought information on attributes of medical tourism motivations and included eight push factor attributes, 10 pull factor attributes, and 13 demographic and medical tourism behavior variables, for a total of 31 items. The surveys were translated into Chinese, Japanese, and English. This paper proposes a market segmentation that consists of three significant segments, the quality seeker, the essential services seeker, and the rest seeker. The results indicate that these segments have strategic implications for reaching individual markets in the medical tourism industry.