bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jacob Mompó Navarro, 'Conversos valencians i Inquisició. Experiències vitals d’una minoria perseguida (1481-1521)', Universitat de València, 2022, 145 p.
Authors: Toldrà i Vilardell Albert 
Published: November 2023

Ressenya sobre el llibre de Jacob Mompó Navarro, Conversos valencians i Inquisició. Experiències vitals d’una minoria perseguida (1481-1521). Universitat de València, 2022, 145 p., ISBN 84-1118-079-5.
Bone marrow mesenchymal stem cell-derived exosomal microRNA regulates microglial polarization
Authors: Huang Xianwei , Liu Xiong , Zeng Jiaqi , Du Penghui , Huang Xiaodong , Lin Jiyan 
Published: November 2023

Objective
This study aimed to explore the effects of bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-146a-5p on microglial polarization and the potential underlying mechanisms in oxygen-glucose deprivation (OGD)-exposed microglial cells.

Methods
Exosomes were isolated from BMSCs, and their characteristics were examined. The effects of BMSC-derived exosomes on microglial polarization were investigated in OGD-exposed BV-2 cells. Differentially expressed miRNAs were identified and their biological function was explored using enrichment analyses. The regulatory role of miR-146a-5p in microglial polarization was studied via flow cytometry. Finally, the downstream target gene Traf6 was validated, and the role of the miR-146a-5p/Traf6 axis in modulating microglial polarization was investigated in OGD-exposed BV-2 cells.

Results
BMSC-derived exosomes were successfully isolated and characterized. A total of 10 upregulated and 33 downregulated miRNAs were identified. Exosomal treatment resulted in significant changes in microglial polarization markers. miR-146a-5p was found to be significantly downregulated in OGD-exposed microglial cells treated with exosomes. Manipulation of miR-146a-5p expression modulated microglial polarization. Moreover, the miR-146a-5p/Traf6 axis regulated microglial polarization.

Conclusion
Our findings demonstrate that BMSC-derived exosomal via miR-146a-5p modulates microglial polarization by targeting Traf6, providing a potential thermal target for the treatment of neurological diseases involving microglial activation.
Navigating the Modernization of Legacy Applications and Data: Effective Strategies and Best Practices
Authors: Ponnusamy Sivakumar , Eswararaj Dinesh 
Published: November 2023

Aims: This research offers an in-depth exploration of the hurdles organizations face during legacy application modernization. The investigation delves into the primary motivations behind modernization, delineates the associated challenges, and proposes viable strategies and best practices to mitigate these issues.
Study Design: This is a Review Article which synthesizes and critically assesses a broad array of sources relevant to legacy application modernization. It amalgamates insights from various studies, offering a comprehensive overview and analysis of existing literature to derive meaningful conclusions and recommendations. Through this approach, the article provides a holistic understanding of the challenges and strategies associated with modernizing legacy systems.
Place and Duration of Study: This global study was conducted over eight years, from January 2016 to August 2023.
Methodology: This research uses a literature review to collect data. In the literature review process, a comprehensive array of data collection methods is strategically employed to ensure the acquisition of a diverse and pertinent body of knowledge concerning the challenges associated with modernizing legacy applications and the effective strategies and best practices to address them. It starts with searching in extensive Online Databases and Repositories, using Keyword Searches and Citation Tracking to find the relevant literature. Systematic reviews and meta-analyses give structured synthesis, while manual searches collect real-world case studies. Grey Literature supplements insights, and Evidence-Based Practices ensure rigor. Thematic Analysis sorts findings, whereas Data Management arranges data, and the Critical Appraisal Skills programme evaluates the credibility of sources. This approach is an important starting point for modernizing legacy systems and developing effective policies and guidelines.
Results: The research identifies business necessities and technological advancements as the predominant catalysts for modernization. It further elucidates the obstacles encountered by organizations during this transition, such as the intricacies of data migration, the complexity inherent in legacy systems, and issues related to user acceptance and integration. The investigation also delves into potential strategies and best practices to navigate these challenges, emphasizing the significance of selecting the right modernization approach.
Conclusion: The existing research underscores that although the path to modernizing legacy applications has obstacles, they can be navigated successfully through astute planning, strategic decision-making, and adept execution. In doing so, organizations have the potential to metamorphose their dated systems into valuable tools that resonate with current business demands and the latest technological advancements.
Conservation Agriculture Strategies Evaluation under Rainfed Conditions
Authors: Devappa  , Rajashekarappa, K. S.  , Mudalagiriyappa  , Devaraj, K.  , Latha, H. S.  
Published: November 2023

Continuous tillage has a significant impact on the characteristics of the soil; therefore, it's critical to use tillage techniques that preserve crop production, prevent soil structure from being destroyed, and provide greater financial returns rather than harming the health of the soil. Practicing agriculture through minimum soil disturbance, incorporation of crop residues through in-situ green manuring enhances the crop growth attributes of pigeon pea under thirsty and nutrient hunger dryland conditions by improving the physicochemical and biological properties of soil. A field investigation was carried out to evaluate conservation agriculture effect on agronomic growth attributes of pigeon pea and set up in spilt plot design. Among all the tillage practices conventional tillage with horse gram in-situ green manuring has recorded maximum plant height, leaves, branches, stem girth at all growth stages and yield attributes. However, M1 witnessed lower benefit to cost ratio than reduced tillage (M2) (1 Harrowing + 1 intercultural operation + pre-emergence herbicide). Farming with zero tillage alone affects the plant growth by excessive weed growth, soil compaction and which results in minimum yield. Therefore optimum number of tillage operations is the key to maintain soil health and to achieve the best benefit for the rupee invested.
Optimization, a Potential Production, GC-MS and Characterization of Dark Green Pigment from New Local Isolate Streptomyces nigra Strain GH12
Authors: Sayed Gehad H. El , Fadel Mohamed , Marzouk Mohamed 
Published: November 2023

Due to increasing health awareness among consumers and the identification of novel pharmacological properties of diverse natural pigments, the market for natural pigments is currently seeing rapid growth. Streptomyces. nigra GH12, a new Actinomycete isolate identified by 16S rRNA used for dark green pigment production. Manipulations of the factors affecting pigment production are the most effective way to have maximum yield of pigment. Starch 2.5% (w/v), ammonium nitrate 0.2% (w/v), dibasic sodium phosphate 0.1% (w/v), inoculums size 6% (v/v), initial pH level of 8, 150 rpm rotation speed, 37 ºC temperature, and 9 days of incubation were found the optimum growth conditions for the highest green pigment production. The extraction of green pigment was performed efficiently with ethanol solvent. Results showed no effect on the pigment content at 40, 50 and 60°C. On heating pigment extract at 70, 80, 90 and 100oC for 60 min, retention of pigment remained as high as 97.4, 93, 86 and 79% of the total pigment density , respectively, even with continuous treatment at 100°C for more 60 min. The results indicated that the pigment extracts exhibited their greatest stabilities at high pH values, i.e. 8.0, 8.5, 9.0 and 10.0, during the entire holding time. The pigment was characterized by full UV-visible spectroscopic screening, where the potential absorption maximum of the target green pigment extract was recorded in the range of 300 ̶ 360 nm, with a λmax at 340 nm. Moreover, the chemical composition diversity of the pigment extract was further investigated by GC/MS analysis that revealed the presence of 57 metabolites in their silylated form.
Hepatitis D
Authors: Negro Francesco , Lok Anna S. 
Published: November 2023

ImportanceHepatitis D virus (HDV) infection occurs in association with hepatitis B virus (HBV) infection and affects approximately 12 million to 72 million people worldwide. HDV causes more rapid progression to cirrhosis and higher rates of hepatocellular carcinoma than HBV alone or hepatitis C virus.ObservationsHDV requires HBV to enter hepatocytes and to assemble and secrete new virions. Acute HDV-HBV coinfection is followed by clearance of both viruses in approximately 95% of people, whereas HDV superinfection in an HBV-infected person results in chronic HDV-HBV infection in more than 90% of infected patients. Chronic hepatitis D causes more rapidly progressive liver disease than HBV alone. Approximately 30% to 70% of patients with chronic hepatitis D have cirrhosis at diagnosis and more than 50% die of liver disease within 10 years of diagnosis. However, recent studies suggested that progression is variable and that more than 50% of people may have an indolent course. Only approximately 20% to 50% of people infected by hepatitis D have been diagnosed due to lack of awareness and limited access to reliable diagnostic tests for the HDV antibody and HDV RNA. The HBV vaccine prevents HDV infection by preventing HBV infection, but no vaccines are available to protect those with established HBV infection against HDV. Interferon alfa inhibits HDV replication and reduces the incidence of liver-related events such as liver decompensation, hepatocellular carcinoma, liver transplant, or mortality from 8.5% per year to 3.3% per year. Adverse effects from interferon alfa such as fatigue, depression, and bone marrow suppression are common. HBV nucleos(t)ide analogues, such as entecavir or tenofovir, are ineffective against HDV. Phase 3 randomized clinical trials of bulevirtide, which blocks entry of HDV into hepatocytes, and lonafarnib, which interferes with HDV assembly, showed that compared with placebo or observation, these therapies attained virological and biochemical response in up to 56% of patients after 96 weeks of bulevirtide monotherapy and 19% after 48 weeks of lonafarnib, ritonavir, and pegylated interferon alfa treatment.Conclusions and RelevanceHDV infection affects approximately 12 million to 72 million people worldwide and is associated with more rapid progression to cirrhosis and liver failure and higher rates of hepatocellular carcinoma than infection with HBV alone. Bulevirtide was recently approved for HDV in Europe, whereas pegylated interferon alfa is the only treatment available in most countries.
Design and implementation of a prototype radiotherapy menu in a patient portal
Authors: O'Sullivan‐Steben Kayla , Galarneau Luc , Judd Susie , Laizner Andrea M. , Williams Tristan , Kildea John 
Published: November 2023

AbstractPurposeRadiotherapy patients often face undue anxiety due to misconceptions about radiation and their inability to visualize their upcoming treatments. Access to their personal treatment plans is one way in which pre‐treatment anxiety may be reduced. But radiotherapy data are quite complex, requiring specialized software for display and necessitating personalized explanations for patients to understand them. Therefore, our goal was to design and implement a novel radiotherapy menu in a patient portal to improve patient access to and understanding of their radiotherapy treatment plans.MethodsA prototype radiotherapy menu was developed in our institution's patient portal following a participatory stakeholder co‐design methodology. Customizable page templates were designed to render key radiotherapy data in the portal's patient‐facing mobile phone app. DICOM‐RT data were used to provide patients with relevant treatment parameters and generate pre‐treatment 3D visualizations of planned treatment beams, while the mCODE data standard was used to provide post‐treatment summaries of the delivered treatments. A focus group was conducted to gather initial patient feedback on the menu.ResultsPre‐treatment: the radiotherapy menu provides patients with a personalized treatment plan overview, including a personalized explanation of their treatment, along with an interactive 3D rendering of their body, and treatment beams for visualization. Post‐treatment: a summary of the delivered radiotherapy is provided, allowing patients to retain a concise personal record of their treatment that can easily be shared with future healthcare providers. Focus group feedback was overwhelmingly positive. Patients highlighted how the intuitive presentation of their complex radiotherapy data would better prepare them for their radiation treatments.ConclusionsWe successfully designed and implemented a prototype radiotherapy menu in our institution's patient portal that improves patient access to and understanding of their radiotherapy data. We used the mCODE data standard to generate post‐treatment summaries in a way that is easily shareable and interoperable.
Synergistic Multilevel Sieving Membranes: Integrating Cellular Graphene Skeleton with Continuous MOFs Nanolayer for Superior Multiphase Water Separation
Authors: Zhang Shizhuo , Yuan Jun , Wang Shuai , Li Yunfan , Xu Yuhang , Sun Dingyue , Liu Feng , Cheng Gary J. 
Published: November 2023

AbstractThe emergence of MOF–based separation membranes has transformed liquid contaminant filtration with impressive sieving properties. However, their use in multiphase water filtration is hindered by a limited sieving range and susceptibility to collapse in solution. To address this challenge, an innovative solution is presented: the Multilevel Cellular Graphene Skeleton (MCGK) induced by femtosecond laser, onto which a continuous MOF nanolayer (CMN), specifically ZIF–8, is grown. This forms a groundbreaking multistage micron/nanocomposite pore membrane. The MCGK/CMN membrane significantly expands the range of filterable contaminants and enhances stability. It utilizes a multilevel, multi–pore size sieving strategy for effective multiphase water filtration, achieving an impressive 90% efficiency in self–driven solar steam generation sieving. Additionally, it excels in removing organic pollutants and over 80% of volatile organic compounds (VOCs), while reducing metal ion concentrations. In liquid pressure–driven filtration, it achieves complete oil adsorption and reduces VOCs and metal ion concentrations. This innovative multistage micron/nanocomposite pore membrane holds great potential for diverse practical applications and provides insights for next–generation nanofiltration membranes, promising more efficient and resilient water purification technologies in the future.
Integrating Fluorescence and Magnetic Resonance Imaging in Biocompatible Scaffold for Real‐Time Bone Repair Monitoring and Assessment
Authors: Yang Ai , Wang Yue , Feng Qian , Fatima Kanwal , Zhang Qianqian , Zhou Xiaojun , He Chuanglong 
Published: November 2023

AbstractIn situ monitoring of bone tissue regeneration progression is critical for the development of bone tissue engineering scaffold. However, engineered scaffolds that can stimulate osteogenic progress and allow for non‐invasive monitoring of in vivo bone regeneration simultaneously are rarely reported. Based on a hard‐and‐soft integration strategy, a multifunctional scaffold composed of 3D printed microfilaments and a hydrogel network containing simvastatin (SV), indocyanine green‐loaded superamphiphiles, and aminated ultrasmall superparamagnetic iron oxide nanoparticles (USPIO‐NH2) is fabricated. Both in vitro and in vivo results demonstrate that the as‐prepared scaffold significantly promotes osteogenesis through controlled SV release. The biocomposite scaffold exhibits alkaline phosphatase‐responsive near‐infrared II fluorescence imaging. Meanwhile, USPIO‐NH2 within the co‐crosslinked nanocomposite network enables the visualization of scaffold degradation by magnetic resonance imaging. Therefore, the biocomposite scaffold enables or facilitates non‐invasive in situ monitoring of neo‐bone formation and scaffold degradation processes following osteogenic stimulation, offering a promising strategy to develop theranostic scaffolds for tissue engineering.
High‐Resolution Intaglio Transfer Printing of Silver Nanowires for Wearable Electrophysiological Sensors
Authors: Kim Hye Hyun , Kim Kiwook , Yang Jiwoong , Choi Moon Kee 
Published: November 2023

Silver nanowires (NWs) are promising materials for flexible electronics, such as electronic skins due to their excellent electrical, thermal, and mechanical properties. Achieving precise patterning of Ag NWs is essential for the successful integration and miniaturization of the electronic device system, but the high aspect ratio (AR) of NWs and the high porosity of NW networks pose challenges in forming high‐resolution patterns. Herein, the intaglio transfer printing technique to create high‐resolution patterning of ultralong Ag NWs (AR≈1000) is presented. During the pattern formation process, the external force becomes concentrated specifically at the edge of the intaglio trench, resulting in the breaking of the entangled Ag NW network in the corresponding region. This simple yet effective technique enables precise high‐resolution (minimum line width: 7 µm) and complicated Ag NW patterns on flexible substrates. The patterned Ag NWs are conformally attached to the various curvilinear surfaces and show high mechanical stability under continuous bending conditions. Wearable electrophysiological sensors are demonstrated to monitor electromyography and electrocardiogram signals in real‐time for continuous healthcare monitoring. This patterning strategy offers an effective approach for achieving high‐resolution patterns of highly anisotropic nanomaterials and highlights the potential of patterned Ag NWs in wearable electronics.
Bimetallic Pd‐Sn Catalytic Electrodes from Deep Eutectic Solvents for Selective Nitrate Reduction Toward Nitrogen
Authors: Kuan Wei‐Fan , Chen Ching‐Lung , Ahmad Muhammad Sheraz , Hsieh Chia‐Hsun , Chen Hao Ming , Su Jenn Fang 
Published: November 2023

AbstractNitrate is one of the most widespread water contaminants globally. Nitrate levels in groundwater and surface water can rise to unhealthy levels as a result of nitrogen fertilizer runoff from lawns and farms. This research aims to selectively convert nitrate to gaseous nitrogen using Palladium‐Tin (Pd‐Sn) bimetallic electrodes electrodeposited on stainless‐steel (SS). Inductively coupled plasma optical emission spectrometry, scanning electron microscope, and X‐ray diffraction are used to analyze the composition, surface morphology, and crystal structure of the electrodes. The XRD analysis reveals that the Pd‐Sn/SS electrode has a crystalline nature when a Pd molar ratio >0.5 while an amorphous phase is detected over a Pd molar ratio (≤0.5). The electrochemical nitrate reduction is carried out in a 0.1 M HClO4 / 8 mM NaNO3 solution for 5 h using electrodes prepared in deep eutectic solvent (DES) system. The Pd0.93Sn0.07/SS electrode shows the best catalytic performance in terms of high nitrate conversion of 97%, N2 selectivity of 88%, and N2 yield of 86% compared to counter electrodes. These findings demonstrate a considerable impact of the electrode preparation process on nitrogen conversion, selectivity, and yield.
Thiol‐Functionalized Conjugated Metal–Organic Frameworks for Stable and Efficient Perovskite Photovoltaics
Authors: Liang Xiao , Singh Mriganka , Wang Fei , Fong Patrick W. K , Ren Zhiwei , Zhou Xianfang , Wan Xuejuan , Sutter‐Fella Carolin M. , Shi Yumeng , Lin Haoran , Zhu Quanyao , Li Gang , Hu Hanlin 
Published: November 2023

AbstractMetal–organic frameworks (MOFs) have been investigated recently in perovskite photovoltaics owing to their potential to boost optoelectronic performance and device stability. However, the impact of variations in the MOF side chain on perovskite characteristics and the mechanism of MOF/perovskite film formation remains unclear. In this study, three nanoscale thiol‐functionalized UiO‐66‐type Zr‐based MOFs (UiO‐66‐(SH)2, UiO‐66‐MSA, and UiO‐66‐DMSA) are systematically employed and examined in perovskite solar cells (PSCs). Among these MOFs, UiO‐66‐(SH)2, with its rigid organic ligands, exhibited a strong interaction with perovskite materials with more efficient suppression of perovskite vacancy defects. More importantly, A detailed and in‐depth discussion is provided on the formation mechanism of UiO‐66‐(SH)2‐assisted perovskite film upon in situ GIWAXS performed during the annealing process. The incorporation of UiO‐66‐(SH)2 additives substantially facilitates the conversion of PbI2 into the perovskite phase, prolongs the duration of stage I, and induces a delayed phase transformation pathway. Consequently, the UiO‐66‐(SH)2‐assisted device demonstrates reduced defect density and superior optoelectronic properties with optimized power conversion efficiency of 24.09% and enhanced long‐term stability under ambient environment and continuous light illumination conditions. This study acts as a helpful design guide for desired MOF/perovskite structures, enabling further advancements in MOF/perovskite optoelectronic devices.
Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy
Authors: Cheng Qian , Shi Xiao‐Lei , Li Qi‐Lin , Wang Lin , Wang Zheng 
Published: November 2023

AbstractIncreasing numbers of studies have shown that tumor cells prefer fermentative glycolysis over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even under oxygen‐sufficient conditions. This metabolic alteration not only favors tumor cell progression and metastasis but also increases lactate accumulation in solid tumors. In addition to serving as a byproduct of glycolytic tumor cells, lactate also plays a central role in the construction of acidic and immunosuppressive tumor microenvironment, resulting in therapeutic tolerance. Recently, targeted drug delivery and inherent therapeutic properties of nanomaterials have attracted great attention, and research on modulating lactate metabolism based on nanomaterials to enhance antitumor therapy has exploded. In this review, the advanced tumor therapy strategies based on nanomaterials that interfere with lactate metabolism are discussed, including inhibiting lactate anabolism, promoting lactate catabolism, and disrupting the “lactate shuttle”. Furthermore, recent advances in combining lactate metabolism modulation with other therapies, including chemotherapy, immunotherapy, photothermal therapy, and reactive oxygen species‐related therapies, etc., which have achieved cooperatively enhanced therapeutic outcomes, are summarized. Finally, foreseeable challenges and prospective developments are also reviewed for the future development of this field.