bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Multiple Facial Lipomas During Immunotherapy for Metastatic Squamous Cell Carcinoma
Authors: Hall Kathryn , Guevara Adrian 
Published: November 2023

An 85-year-old Caucasian male on immunotherapy for metastatic squamous cell carcinoma presented with enlarging lipomas in the area of his previous invasive squamous cell carcinoma of the lower lip and chin, status post resection, reconstruction and local radiation. The development of multiple lipomas during immunotherapy is a novel association which has yet to be reported in the literature. We discuss a putative mechanism of action of pembrolizumab-induced lipomas and describe the patient's clinical course.
Deucravacitinib Long-term Efficacy With Continuous Treatment in Plaque Psoriasis: 2-Year Results From the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Thaçi Diamant , Lebwohl Mark , Warren Richard B. , Kircik Leon , Banerjee Subhashis , Napoli Andrew , Kisa Renata M. , Linaberry Misti , Hoyt Kim , Blauvelt Andrew 
Published: November 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the US, EU, and other countries for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. Deucravacitinib treatment was superior to placebo and apremilast in the POETYK PSO-1 (NCT03624127) and POETYK PSO-2 (NCT03611751) trials in moderate to severe plaque psoriasis. We evaluated long-term clinical outcomes in patients with ≈2 years (112 weeks) of continuous deucravacitinib exposure.
Methods: PSO-1 and PSO-2 patients were randomized 1:2:1 to oral placebo, deucravacitinib 6 mg once daily, or apremilast 30 mg twice daily. At Week 52, patients were eligible to enroll in the POETYK long-term extension (LTE; NCT04036435) trial and receive deucravacitinib 6 mg once daily. Efficacy outcomes included ≥75%/≥90% reduction from baseline in Psoriasis Area and Severity Index (PASI 75/90) and static Physician Global Assessment score of 0 (clear) or 1 (almost clear) with a ≥2-point improvement from baseline (sPGA 0/1). Efficacy was assessed using modified nonresponder imputation through the data cutoff date of October 1, 2021 (Week 112) in patients receiving continuous deucravacitinib treatment from Day 1 and in patients receiving continuous deucravacitinib treatment who achieved PASI 75 at Week 24. As-observed data and results by treatment failure rules imputation were also analyzed.
Results: A total of 513 patients received continuous deucravacitinib from Day 1 in PSO-1/PSO-2 until Week 112 in the LTE, including 336 patients who had achieved PASI 75 at Week 24. High clinical response rates achieved at Week 52 in PSO-1/PSO-2 (PASI 75, 73.0%; PASI 90, 46.3%; sPGA 0/1, 58.5%) were maintained at Week 112 in the LTE (PASI 75, 76.2%; PASI 90, 48.3%; sPGA 0/1, 58.4%) among patients receiving continuous deucravacitinib treatment from Day 1. High response rates were also maintained in Week 24 PASI 75 responders (Week 52: PASI 75, 90.3%: PASI 90, 62.1%: sPGA 0/1, 73.8%; Week 112: PASI 75, 89.2%; PASI 90, 61.1%; sPGA 0/1, 70.5%). Results were consistent regardless of data imputation methodology.
Conclusion: Deucravacitinib was associated with sustained efficacy through 2 years in patients who received continuous treatment from Day 1 and in patients who achieved PASI 75 at Week 24. High clinical response rates achieved at Week 52 were maintained at Week 112. These findings provide additional support for deucravacitinib as an efficacious long-term treatment for moderate to severe plaque psoriasis.
Abstracts of invited presentations at EuroPD congress in Bruges, 2023-11-27
Authors: EuroPD  
Published: November 2023

This special issue of the Home Dialysis Bulletin (cross-referenced as Bulletin de la Dialyse à Domicile (BDD)) contains abstracts of guest lectures submitted by the authors.
The abstracts are available in English and French.
The abstracts of the free communications are available at this link.
Many of these abstracts reflect work of particular interest to clinicians and nurses and should be developed into a full article. We, therefore, encourage authors to write a full article and submit it to the BDD at https://www.bdd.rdplf.org if it has not been published or submitted elsewhere. They will be double-blind peer-reviewed and, if accepted, will be published promptly in both languages to ensure the widest possible dissemination.
The BDD supports the Diamond Open Access Action Plan and follows its model (Diamond OA scholarly Communication Ecosystem); it is therefore free of charge for authors and readers and accessible to all health professionals and patients.

Ethical considerations: before submitting their abstracts, all authors were informed that their articles would be published in the BDD and translated into French. Authors retain the copyright of their articles.Declaration of interests: Publication of these abstracts is provided free of charge by the French Registry of Peritoneal Dialysis and Home Hemodialysis. No payment or grant has been received from EuroPD or any third party for this work.Copyright: authors retain copyright.
Open data on road traffic accidents accumulation, processing and analysis
Authors: Goryaev N. K. , Lyubetskii S. P. 
Published: November 2023

Introduction. An urgent task for any municipality is the development of an Integrated Traffic Management Scheme, which is based on an analysis of the current situation. At the same time, the most important element is the analysis of road traffic accidents (RTA). The purpose of this study is to develop a methodology for accumulating, processing and analyzing the data on road accidents from the main official source - the State Inspectorate for Road Safety (GIBDD).Description of the problem. The data can be uploaded from the traffic police portal in two formats, but none of them allows for automated analysis of road accidents and presentation of its results using geographic information systems (GIS).Proposed methodology. The paper proposes a methodology for analyzing traffic accidents, including the following steps: uploading data from the site, converting data into convenient formats, entering data into a geographic information system, analyzing data using geographic information systems.Methodology approbation. Using the proposed methodology, an analysis of traffic accidents in the Cheboksary agglomeration was made and its visualization was made using GIS.Conclusions. The use of information about road accidents in the formats offered on the traffic police website is impossible either for analysis or for visualization in a GIS. The proposed method for accumulating, processing and analyzing accidents based on data from an official source using GIS makes it possible to automate the process and improve the quality of accident analysis.
On possible petrol ignition on М<sub>1</sub>, М<sub>1</sub>G car catalyst converters surface
Authors: Nedobitkov A. I. , Yakovlev V. S. 
Published: November 2023

Introduction. Forensic fire and technical examination of a car is of high demand, and at the same time it is one of the most complicated examinations, because of its complicated nature and need in involvement of experts of various specialties. The design of automobiles and their components is continually improving. In this connection the methodological base of fire and technical examination should be duly adapted to present-day requirement. The safety requirements for prevention of fuel ignitions in a motor cabinet of a car have been analyzed during the research.Materials and Methods. Under the conditions of an accredited laboratory specializing in testing automobile fuels and oils, we have carried out the experiments in ignition of K4-class petrol being fed in drops and stream-like fed on a hot surface. We have also undertaken the experimental studies in order to find out an actual temperature of elements of engine exhaust systems of М1 and М1G automobiles of various models under the actual operating conditions. A thermal imaging camera and a thermocouple have been used to measure the surface temperature of the engine exhaust system parts. An elemental composition of a film formed on a hot steel surface upon contact with petrol has been determined with the use of a scanning electron microscopeResults. We have received the actual results on the temperature of the elements of light car exhaust systems under the various operating conditions. There are the results of experiments on the discharge of the petrol in the form of drops and stream on a hot surface presented in the article. An elemental composition of a film formed on a hot steel surface upon contact with petrol has been analyzed, and secondariness of film formation towards the fire cause has been proved.Conclusion. The results of the research could be used in the conduct of fire and technical examination of vehicles of М1 and М1G categories, what could increase reliability and validity of its conclusions.
Analysis of The Effect of Tax Socialization, Tax Sanction, and Quality of Service of Tax Officials on MSME Taxpayer Compliance (Case Study on Individual and Entity Taxpayers in Pati Regency)
Authors: Janan Samahul , Mokhlas Mokhlas 
Published: November 2023

<p> </p><p>This study aims to determine the effect of Tax Socialization, Tax Sanctions, and Service Quality of Tax Officers on MSME Taxpayer Compliance.The population in this study are individual taxpayers and MSME entities registered at the KPP Pratama Pati Regency. Samples were taken as many as 100 respondents using the incidental sampling method, namely a sampling technique where the distribution of questionnaires in this case was carried out to respondents who were willing or willing to be asked for data by researchers. While collecting data using a questionnaire. The results of this study indicate that Tax Socialization has a significant positive effect on Taxpayer Compliance, Tax Sanctions have a significant positive effect on Taxpayer Compliance, and Service Quality of Tax Officers has a significant positive effect on Taxpayer Compliance, and Tax Dissemination, Tax Sanctions and Service Quality of Tax Officers simultaneously significant positive effect on Taxpayer Compliance.</p><p> </p><p> </p>
The Effect of Financial Ratio Performance on Credit Distribution (Study on Commercial Banks in Indonesia for the 2020-2022 Period)
Authors: Charakas Nana Yohana , Putri Ika Swasti 
Published: November 2023

<p>The goal to be realized in this study is to provide partial or simultaneous empirical evidence of the effect of CAR, NPL, LDR, ROA, DPK on lending. In this research using secondary data. The sample in this research amounted to 60 data using a purposive sampling technique. In analyzing the data using multiple linear regression analysis test, t test, F test and the coefficient of determination. Relying on the results obtained in partial and simultaneous research CAR, NPL, ROA have a non-significant positive effect on lending, LDR, DPK have a significant positive influence on lending. The results of the calculation of the coefficient of determination are 99.2% while the remaining 0.8%.</p><p><strong>Keywords </strong>: Lending, CAR, NPL, LDR, ROA, DPK.</p>
Edukasi Kesehatan dan Olahraga Sebagai Pencegahan Obesitas dan Perilaku Sedentari Pada Siswa
Authors: Agafian Dhuha Ahad , Yogaswara Andre , Seh Abu Bakar Sayid Fariz bin , Widodo Agung , Muhibbi Muhammad , Mif Mifbakhuddin , Prasetio Diki Bima , S Sayono , Sumanto Didik 
Published: November 2023

Latar belakang: Obesitas sudah menjadi epidemi global penyakit tidak menular yang mengancam seluruh penduduk dunia. Obesitas merupakan kondisi yang diakibatkan oleh tidak seimbangnya intake makanan yang masuk dengan energi yang dikeluarkan sehingga menyebabkan tumpukan lemak di dalam tubuh. Tujuan: untuk melakukan edukasi remaja terkait kebugaran dan kesehatan agar tidak terjebak dalam perangkap kemajuan teknologi yang membawa pada perilaku sedentary. Metode: Pengabdian dilaksanakan dalam bentuk edukasi melalui ceramah dan praktik latihan langsung di kelas. Pengetahuan responden diambil dengan kuesioner sebelum dan setelah kegiatan berlangsung. Hasil: siswa hanya melakukan aktivitas fisik 1 kali dalam seminggu yaitu saat jam pelajaran penjaskes di sekolah. Rerata denyut nadi siswa berkisar antara 90-100 kali per menit. Pada latihan kebugaran push up, kategori kurang sebanyak 28 siswa, kategori cukup 7 siswa, dan kategori baik 3 siswa. Tes kebugaran sit up, kategori kurang sebanyak 26 siswa, kategori cukup 6 siswa, kategori baik 6 siswa. Kesimpulan: Sebagian besar tingkat kebugaran jasmani siswa SMA MIBS Kebumen dalam kategori kurang. Edukasi meningkatkan pengetahuan siswa tentang kesehatan dan kebugaran.
Kata kunci: obesitas, sedentari, kebugaran
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Abstract
Background: Obesity has become a global epidemic of non-communicable diseases threatening the entire world's population. Obesity is caused by an imbalance between incoming food intake and expended energy, causing fat deposits in the body. Objective: educate youth about fitness and health so they don't get caught in the trap of technological advances that lead to sedentary behavior. Method: Community service is done through education through lectures and hands-on practice in class. Respondents' knowledge was taken with a questionnaire before and after the activity. Result: students only do physical activity once a week at school, namely during physical education lessons. The average student's pulse ranges from 90-100 beats per minute. In the push-up fitness exercise, there were 28 students in the less category, seven students in the sufficient, and three in the good. Sit-up fitness test, 26 students were lacking, six were adequate, and six students were good. Conclusion: Most of the physical fitness levels of SMA MIBS Kebumen students are in the poor category. Education increases students' knowledge about health and wellness.
Keywords: obesity, sedentary, fitness
Efficient removal of lead(II) ions in water using functionalized poly(styrene) oligomers
Authors: Sánchez Anguiano Maria G. , Oliva de Dios Mauricio L. , Chan Navarro Rodrigo , Elizondo Martínez Perla , Rosa M.  , García López María Concepción 
Published: November 2023

In this research, chemically functionalized polystyrene oligomers with acrylamide monomers were applied as alternative adsorbent towards Pb(II) from aqueous solutions. Adsorption process of Pb(II) was optimized using the 2*' fractional factorial design with replicates at the central point supplemented with the central composite design where the percentage adsorption was chosen as the response variable. This variable was simultancously optimized using the desirability functions approach to select the best conditions for the adsorption process. The experimental data reveal that after the optimization, the maximal response was exhibited at 38 °C, pH 5.80, initial adsorbate concentration (36.40 mg L™, and adsorbent dosage (10.77 mg) with the desirability function of 0.9260. Theoretical values and experimental data determined by the central composite design showed a high correlation with a R? value of 0.9810. Under these optimal conditions, the theoretical value for the removal of Pb(II) was 93.12%, while that experimental assay gives a maximum value of 91.23%. Likewise, the analysis of surface charge distribution, the structural and morphological characteristics confirmed the successful chemical modification of poly(styrene) oligomers.
EDUKASI DAN PELATIHAN PEMERIKSAAN INFEKSI SALURAN KEMIH (ISK) PADA SISWA SMK TEKNOLOGI LABORATORIUM MEDIS (TLM) DI KOTA BEKASI
Authors: Anindita Reza , Nurfajriah Siti , Amelia Ria , Andryan Ilsan Noor , Inggraini Maulin , Maya Sari Elfira 
Published: November 2023

Infeksi Saluran Kemih (ISK) merupakan penyakit infeksi yang disebabkan kolonisasi bakteri di dalam salurah kemih. Secara bakteri yang paling banyak ditemukan pada pasien ISK adalah E. coli. Penyakit ISK banyak ditemukan pada perempuan (79%) daripada laki-laki (21 %) dengan usia 17-35 tahun. Masalah penyakit ISK menyebabkan peningkatan angka morbiditas (kesakitan) sehingga meningkatkan biaya pengobatan. Oleh sebab itu, diperlukan upaya pencegahan sejak dini, salah satunya melalui edukasi dan pengenalan pemeriksaan ISK melalui kegiatan Pengabdian Kepada Masyarakat (PKM) pada siswa sekolah menengah. Tujuan PKM ini memberikan edukasi dan pelatihan sederhana mengenai pemeriksaan ISK pada siswa SMK jurusan TLM di Kota Bekasi. PKM ini juga memberikan pengalaman kepada pada siswa untuk melakukan pemeriksaan ISK secara laboratorium. Kegiatan ini dilaksanakan di STIKES mitra keluarga dengan jumlah peserta SMK jurusan TLM sebanyak 43 siswa. Tahap kegiatan ini meliputi perencanaan, pelaksanaan, dan evaluasi. Analisis data dilakukan dengan uji deskriptif dan komparatif 2 sampel menggunakan uji t-tes berpasangan (paired t-test). Hasil kegiatan ini menunjukkan peserta perempuan berjumlah 37 (86,04%) orang sedangkan laki-laki berjumlah 6 (13,95%) orang. Nilai rata-rata pre-test sebesar 3,48 sedangkan post-test sebesar 8,76 atau mengalami peningkatan sebesar 15,17 %. Hasil uji t-tes berpasangan menunjukkan perbedaan secara nyata antara pre-test dan post-test dengan nilai signifikansi sebesar (0,306<0,05). Kesimpulan dari PKM ini adalah evaluasi menggunakan instrumen tes (pre test dan post test) dalam bentuk 10 soal pilihan ganda mampu meningkatkan pengetahuan mengenai ISK terhadap 43 siswa SMK Kesehatan Jurusan TLM di Kota Bekasi secara nyata.
A EFEKTIVITAS EKSTRAK DAUN BAWANG DAYAK SEBAGAI PENGHAMBAT BIOFILM PADA BAKTERI Escherichia coli
Authors: Lihawa Riska Narti K. , M.Hasan Ani , Kibu Alfandi 
Published: November 2023

Escherichia coli merupakan flora normal pada saluran pencernaan tetapi mempunyai potensi menimbulkan penyakit E. coli menjadi patogen jika jumlahnya dalam saluran pencernaan meningkat seperti mengkonsumsi air maupun makanan yang terkontaminasi atau masuk ke dalam tubuh dengan sistem kekebalan yang rendah seperti pada bayi, anak, lansia dan orang yang sedang sakit. Beberapa strain E. coli seperti EPEC dan ETEC bersifat patogenik maupun toksigenik sehingga pertumbuhannya harus dihambat (Jawetz E, dkk. 2013). Biofilm adalah komunitas mikroorganisme yang terdiri dari sel-sel mikroba yang terhubung satu sama lain dalam matriks yang diproduksi sendiri yang terbentuk dari komponen polimer ekstraseluler pada atau dalam organisme inang. Tujuan dari peneliatian ini yaitu untuk melihat apakah ekstrak daun bawang dayak dapat menghambat biofilm pada bakteri Escherichia coli. Penelitian ini menggunakan metode pendekatan kualitatif, di mana Pendekatan kualitatif merupakan pendekatan yang lebih menekankan pada aspek pemahaman secara mendalam terhadap suatu masalah daripada melihat permasalahan untuk melihat generalisasi Penelitian ini menggunaka metode kualitatif dan data dianalisis secara deskriptif. Hasil yang didapatkan bahwa ekstrak daun bawang dayak dengan konsentrasi 2ml Escherichia coli mampu menghambat pembentukan biofilm pada bakteri Escherichia coli
Pelatihan Pembuatan Spesimen Tumbuhan Dalam Blok Resin Untuk Media Pembelajaran Biologi Bagi Siswa
Authors: Kamilah Santi Nurul Kamilah , Helmiyetti Helmiyetti , Supriati Rochmah , Astuti Sri , Nurliana Steffanie , Atmaja Vestidhia Yunisya 
Published: November 2023

Spesimen awetan biologi di dalam blok resin merupakan salah satu alat peraga yang menarik dan bermanfaat untuk meningkatkan minat serta pemahaman siswa dalam pelajaran biologi. Namun ketersediaannya masih sangat terbatas di sekolah-sekolah, termasuk di SMA Negeri 6 Kota Bengkulu. Oleh karena itu kami melakukan pelatihan pembuatan spesimen awetan biologi ini dengan sasarannya siswa dari sekolah tersebut dengan tujuan untuk meningkatkan pemahaman dan kreativitas siswa mengenai pembuatan spesimen awetan biologi dalam blok resin. Pelaksanaan kegiatan diawali dengan pemaparan materi, praktik pembuatan spesimen awetan daun dengan berbagai tipe ujung daun, evaluasi pencapaian dari pelaksanaan pelatihan. Hasil evaluasi menunjukkan bahwa 96% siswa telah memahami cara dan mampu membuat spesimen awetan daun dalam blok resin dengan hasil yang cukup baik, namun kualitas dan tampilannya masih perlu ditingkatkan. Karya siswa ini dapat dimanfaatkan menjadi salah satu alat peraga pembelajaran khususnya mengenai variasi tipe ujung daun pada mata pelajaran biologi. Rangkaian kegiatan yang dilaksanakan ini telah memberi manfaat dalam meningkatkan pengetahuan siswa mengenai pembuatan awetan spesimen dalam blok resin. Rencana lanjutan dari siswa adalah meneruskan informasi dan keterampilannya pada siswa lainnya, membuat awetan spesimen serangga dalam blok resin serta membuat karya seni berbahan resin berupa suvenir yang akan dipergunakan dalam kegiatan lomba karya seni siswa.

Biological specimens preserved in resin blocks are fascinating instruments that can be used as a teaching aid to boost students' interest and comprehension in biology lectures. However, its availability in schools remains limited, especially at SMA Negeri 6 Bengkulu. Therefore, we conducted training on how to make the biological specimens preserved in resin blocks to boost students' awareness and inventiveness about the biological specimens preserved in resin blocks. The activity begins with an explanation of biological specimens, followed by a hands-on experiment of making preserved leaf specimens with various types of leaf tips and an evaluation of the activity's achievement. The evaluation results showed that about 96% of students understood how to prepare and were able to create specimens preserved in resin blocks, however, the quality still needed to be improved. This student's work can be used as a learning tool, particularly in biology classes on the lesson of leaf tip variances. The activities carried out contributed to enhancing students' knowledge of how to create preserved specimens in resin blocks. The students’ next plan is to share their skills and experience with other students, preserve insect specimens in resin blocks, and create resin art in the form of souvenirs to be applied in student art contest activities.