bluuebunny/crossref_metadata_2025_split huggingface dataset:
The patient’s first point of contact (PINPOINT) – protocol of a prospective multicenter study of communication and decision-making during patient assessments by primary care registered nurses
Authors: Sundler Annelie J , Hedén Lena , Holmström Inger K , vanDulmen Sandra , Bergman Karin , Östensson Sofia , Östman Malin 
Published: October 2023

Abstract
Background
A major challenge for primary care is to set priorities and balance demands with available resources. The registered nurses in this study are practice nurses working in primary care offices, playing a large role in initial assessments. The overall objective of this research is to investigate practices of communication and decision-making during nurses’ initial assessment of patients’ health problems in primary care, examine working mechanisms in good practices and develop feasible solutions.
Methods
Project PINPOINT aims for a prospective multicenter study using various methods for data collection and analysis. A purposive sample of 150 patient‒nurse consultations, including 30 nurses and 150 patients, will be recruited at primary care centers in three different geographic areas of southwest Sweden. The study will report on outcomes of communication practices in relation to patient-reported expectations and experiences, communication processes and patient involvement, assessment and decision-making, related priorities and value conflicts with data from patient questionnaires, audio-recorded real-time communication, and reflective interviews with nurses.
Discussion
This research will contribute to the knowledge needed for the guidance of first-line decision-making processes to best meet patient and public health needs. This knowledge is necessary for the development of assessments and decisions to be better aligned to patients and to set priorities. Insights from this research can empower patients and service providers and help understand and enhance feasible person-centered communication strategies tailored to patients’ level of health literacy. More specifically, this research will contribute to knowledge that can strengthen nurses' communication, assessments, and clinical decision-making in primary care. In the long term, this will contribute to how the competencies of practice nurses and other professionals are organized and carried out to make the best use of the resources within primary care.
Trial registration:
ClinicalTrials.gov Identifier: NCT06067672.
Effects of co-sleeping on the sleep pattern in young preschoolers: an observational cross-sectional study
Authors: Garrido Felipe , González-Caballero Juan-Luis , García Pilar , Gianni Maria-Lorella , Garrido Silvia , Gonzalez Lucia , Atance Verónica , Raffaeli Genny , Cavallaro Giacomo 
Published: October 2023

Abstract
Purpose
This study aimed to investigate the association between co-sleeping practiced during the first year of life and preschoolers' sleep patterns.
Methods
A prospective, cross-sectional study was designed to analyze including preschoolers between the ages of 12 and 30 months. The Brief Infant Sleep Questionnaire validated in Spanish was used to measure sleep quality. A latent class analysis was performed to identify qualitative subgroups in the sample and explore the effects of co-sleeping and other variables.
Results
The sleep patterns of 276 children were finally analyzed. A total of 181 (65.6%) mothers reported having practiced co-sleeping with their children. The latent class analysis identified a two-class solution with two different sleep patterns. One of them showed a worse quality sleep pattern. This pattern, defined as "Sleep-Disordered Pattern", showed a significant association with having practiced co-sleeping during the first year of life. In the logistic regression model, having practiced co-sleeping during the first year resulted to be independently associated with the "Sleep-Disordered Pattern" (odds ratio 2.83).
Conclusions
Based on the present findings co-sleeping during the first year of life appears to be associated with poor sleep patterns of young preschoolers.
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis
Authors: Terron Heather M. , Parikh Sagar J. , Abdul-Hay Samer O. , Sahara Tomoko , Kang Dongcheul , Dickson Dennis W. , Saftig Paul , LaFerla Frank M. , Lane Shelley , Leissring Malcolm A. 
Published: October 2023

Abstract
Background
Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined the role of CatD in the development of Aβ pathology and tauopathy in vivo.
Methods
CatD knockout (KO) mice were crossed to human amyloid precursor protein (hAPP) transgenic mice, and amyloid burden was quantified by ELISA and immunohistochemistry (IHC). Tauopathy in CatD-KO mice, as initially suggested by Gallyas silver staining, was further characterized by extensive IHC and biochemical analyses. Controls included human tau transgenic mice (JNPL3) and another mouse model characterized by pronounced lysosomal dysfunction (Krabbe A). Additional experiments examined the effects of CatD inhibition on tau catabolism in vitro and in cultured neuroblastoma cells with inducible expression of human tau.
Results
Deletion of CatD in hAPP transgenic mice triggers large increases in cerebral Aβ, manifesting as intense, exclusively intracellular aggregates; extracellular Aβ deposition, by contrast, is neither triggered by CatD deletion, nor affected in older, haploinsufficient mice. Unexpectedly, CatDKO mice were found to develop prominent tauopathy by just ~ 3 weeks of age, accumulating sarkosyl-insoluble, hyperphosphorylated tau exceeding the pathology in aged JNPL3 mice. CatDKO mice exhibit pronounced perinuclear Gallyas silver staining reminiscent of mature neurofibrillary tangles in human AD, together with widespread phospho-tau immunoreactivity. Striking increases in sarkosyl-insoluble phospho-tau (~ 1250%) are present in CatD-KO mice, but notably absent from Krabbe A mice collected at an identical antemortem interval. In vitro and in cultured cells, we show that tau catabolism is slowed by blockade of CatD proteolytic activity, including via competitive inhibition by Aβ42.
Conclusions
Our findings support a major role for CatD in the proteostasis of both Aβ and tau in vivo. To our knowledge, CatD-KO mice are the only model to develop detectable Aβ acumulation and profound tauopathy in the absence of overexpression of hAPP or human tau with disease-associated mutations. Given that tauopathy emerges from disruption of CatD, which can itself be potently inhibited by Aβ42, our findings suggest that impaired CatD activity may represent a key mechanism linking amyloid accumulation and tauopathy in AD.
Band gaps engineering of the lead-free perovskites FABI3 (B= Sn, Ge or Pb) materials for all Pb-free Tandem Solar Cells: first principle investigation of structural and electronic properties
Authors: Arfaoui Youssef El , Khenfouch Mohammed , Habiballah Nabil 
Published: October 2023

Abstract
Pb-free perovskites are novel compounds that are currently most studied for their photovoltaic application in solar cells due to their less toxicity. In this paper, we are studying the Hybrid-Organic-Inorganic perovskite (HOIP) for photovoltaic application. In fact, we study and discuss the structural and electronic properties of the perovskite FABI3 (B= Sn, Ge or Pb) applying the DFT method executed in the Quantum Espresso framework. The band structure these perovskites has been presented; it is showed that these perovskits has a semi-conductor nature, with a band gap value 1.36eV for FASnI3, 1.72eV for FAGeI3 and 1.61eV for FAPbI3. Also, the DOS and PDOS have been presented and discussed of each one of these materials. Indeed, we investigate the structural properties of these perovskites and demonstrated that the optimized value of lattice parameter is 6.35Å for the FASnI3, While, for the FAGeI3, this value is 6.3Å. And 6.5Å for FAPbI3. Moreover, the impact of the lattice parameter on the band gap value of FABI3 (B =Sn, Ge or Pb) has been investigated, it is demonstrated that the lattice parameter increases, the band gap increases. The results of this work can be utilized as a guideline for the development of new efficient, lead-free perovskite devices including tandem solar cells.
Effects of Romosozumab on Bone Mineral Density and Fractures; a Univariate Meta Analysis
Authors: Dilshani S. D. M. , Jayasekara L. A. L. W. , Liyanage G. , Lekamwasam S. 
Published: October 2023

Abstract
Purpose
Romosozumab, a monoclonal antibody has been approved for the treatment of postmenopausal women with osteoporosis and high fracture risk. This meta-analysis evaluated the effect of romosozumab on Bone Mineral Density (BMD) and fracture occurrence in postmenopausal women with osteoporosis.
Methods
A systematic search was done adhered to the PRISMA guidelines in PubMed, Ovid and Clinicaltrials.gov and eligible studies were selected. In addition to details related to study participants, changes in BMD at the lumber spine (LS), total hip (TH) and femoral neck (FN) and the occurrence of fractures during the study period were extracted. The mean differences of BMDs between the two study groups and odds ratios (OR) of fractures were considered as the outcome of studies.
Results
Of the 11 potentially eligible articles, four were included in the meta-analysis. Romosozumab therapy for 12 months increased mean BMD at the LS by 12.7% (95% CI, 9.7, 15.6), TH by 4.8% (95% CI, 3.3,6.3) and FN by 4.3% (95% CI, 3.1, 5.5). Treatment with romosozumab was associated with 54% and 25% reduction of new vertebral (OR = 0.46, CI, 0.23,0.91) and non-vertebral fractures (OR = 0.75, CI, 0.53,1.06) respectively at the end of 12months.
Conclusion
In conclusion, romosozumab significantly increases BMD at LS, TH and FN and reduces the risk of new vertebral and non-vertebral fractures in postmenopausal women with osteoporosis.
Double-walled carbon nanotubes synthesis by pulsed electric arc discharge with spinning anode
Authors: Saucedo-Jimenez David , Medina-Sánchez Isaac , Padilla-Pérez Diego A. , Couder-Castañeda Carlos , Sanchez Jose Luis Luna 
Published: October 2023

Abstract
This research demonstrates that double-walled carbon nanotubes can be synthesized using the pulsed electric arc discharge with the spinning anode method (PEADSA). This method can be arranged in various experimental configurations to synthesize carbon nanostructures. With this method, the frequency of the pulsed discharge can be controlled, as well as the discharge onset, which directly affects the nucleation and growth of carbon nanotubes. Scanning (SEM) and transmission (TEM) electron microscopy and Raman spectroscopy were used. The desired double-walled carbon nanotubes were obtained with an internal diameter of 0.82 – 1.52 nm and an external diameter of 1.52 – 2.33 nm.
WITHDRAWN: An efficient dual layer data aggregation scheme in clustered wireless sensor networks
Authors: Yang Fenting , Xu Zhen , Yang Lei 
Published: October 2023

Abstract

In wireless sensor network monitoring system, redundant data from sluggish environmental changes and overlapping sensing ranges can increase the volume of data sent by nodes, degrade the efficiency of information collection, and lead to the death of sensor nodes. In order to reduce energy consumption of sensor nodes and prolong the life of wireless sensor networks, this paper proposed a dual layer intra-cluster data fusion scheme based on ring buffer (DLIDF). To reduce redundant data and temporary anomalous data while guaranteeing the temporal coherence of data, the source nodes employ a binarized similarity function and sliding quartile detection based on ring buffer. Based on the improved support degree function of weighted Pearson distance, the cluster head node performs a weighted fusion on the data received from the source nodes. Experiment results reveal that the scheme proposed in this paper has clear advantages in three aspects: the number of remaining nodes, the residual energy, and the number of packets transmitted.
Investigating flow induced mechanics of strain-engineered microcantilevers integrated in a flow-through system
Authors: Islam Mohammad S. , Challa Sushmita , Wei Danming , Beharic Jasmin , Popa Dan O. , Harnett Cindy K. 
Published: October 2023

Abstract
In this work we report the fabrication of stress-driven curled-up microcantilevers based on a metal-oxide bilayer design and their mechanical characterization in a flow-through system. Microcantilever arrays are realized by using conventional micromachining techniques involving optical lithography and etching processes. Due to the geometry of the out-of-plane curled cantilever, the load applied by the fluid flow is distributed along its body. These cantilevers showed mechanical robustness at flow velocity and drag force ranges of 0.48–5.7 mm/s and 0.35–4.23 µN, respectively for operation with glycerol. This fluid-driven approach enables us to measure multiple structures at once and get statistics on their mechanical performance, durability, and applicability in different devices.
Oral expression following COVID-19: A systematic review
Authors: Gibeili Chloé , Marchesseau Louis , Boisramé Sylvie 
Published: October 2023

Abstract
Objective: The aim of this study was to systematically review the literature to gather the oral manifestations of coronavirus disease-2019 (Covid-19), evaluate a direct accountability for severe acute respiratory syndrome-coronavirus 2 (SARS-Cov2), and determine a correlation between ACE2 receptor oral tissue density and Covid-19 lesions. Materials and Methods: PubMed and Web of Science were searched from January 2020 to April 2022; the principal outcome was oral manifestations in PCR-tested patients positive for Covid-19. PRISMA protocol was used to evaluate the results. Results: Among the 535 articles reviewed, 80 were included and analyzed. Oral ulcerations were found most frequently as dermatologic lesions, followed by erythema and macules (as a harbinger or not of ulcerations). Direct accountability was difficult to establish because of the systemic proinflammatory stimulation following Covid-19. Lesion topography was essentially lingual and palatal according to an ACE2 high-density tissue level and recent histologic evidence of SARS-Cov2 presence in the lesions. A direct inflammation of the salivary glands was also reported. Conclusion: Evidence to distinguish direct and indirect etiologies of the SARS-Cov2 virus following Covid-19 infection was poor. It could be deepened by investigating the presence of the SARS-Cov2 virus in tissue lesions and tissue disorders activated by ACE2 pathways.
Unravelling Role of the Microwave Sintering Effects on Microstructure, Density, and Corrosion Behavior of porous Ti-13.3at.% Nb Shape Memory Alloys
Authors: Ibrahim Mustafa K. , Al-Humairi Safaa N. Saud 
Published: October 2023

Abstract
This study investigates the impact of microwave sintering on the microstructure, density, and corrosion behaviour of porous Ti-13.3at.% Nb shape memory alloys (SMAs). The alloys were subjected to microwave sintering at 800°C and 1100°C for 20 and 40 minutes, focusing on understanding the structural changes and corrosion resistance. Microstructural characterization, including scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and electron backscatter diffraction (EBSD), were performed. The results revealed the formation of two distinct needle-like morphologies: straight and cross-linked needles (βSC) and irregular lines or spaghetti-like needles (βS). The area fraction of these needle structures increased with prolonged sintering duration and elevated sintering temperature, indicating enhanced diffusion between Ti and Nb elements. Density measurements showed a range of 73-75.5%, with the highest density (75.5%) achieved for samples sintered at 800°C for 40 minutes. However, a lower density (73%) was observed for samples sintered at 1100°C for 20 minutes, attributed to the rapid heating rate of microwave sintering. Corrosion characteristics were evaluated using potentiodynamic polarization (PDP) and electrochemical impedance spectra (EIS) in simulated body fluid (SBF). The corrosion behaviour was significantly influenced by sintering temperature rather than sintering duration. Samples sintered at 1100°C exhibited larger capacitive loops on their Nyquist plots compared to those sintered at 800°C, indicating improved corrosion resistance. With the 800°C sintering temperature, the sintering duration had a less pronounced impact on corrosion behaviour. The EBSD analysis revealed that Ti-Nb diffusion predominantly occurred at grain boundaries, with reduced diffusion in areas further from the grain boundaries. In conclusion, this study elucidates the profound influence of microwave sintering parameters on the microstructure and corrosion behaviour of porous Ti-13.3at.% Nb SMAs. The findings provide valuable insights into optimizing the sintering process for enhanced material properties, offering potential applications in biocompatible and corrosion-resistant engineering components.
Nuclear factor E2-related factor 2 knockdown alters adipose-phenotype and increases expression of genes involved in longevity in 3T3-L1 cells
Authors: Yuan Xiao-yang , Wang Hua-long , Xie Bingchuan , Ding Yan 
Published: October 2023

Abstract
This study aimed to assess in vitro the impacts of Nuclear factor E2-related factor 2 (Nrf2) knockdown on the transformation of adipose phenotype and the possible mechanisms of resistance to aging in 3T3-L1 cells. In the current study, the Nrf2-knockdown (NK) via siRNA transfection increased the expression of brown adipose tissue (BAT) marker genes including PGC-1α, Dio2 and PRDM16 and lowered the gene and protein expression of white adipose tissue (WAT) marker genes for instance BMP4, Resistin and Rb1 in adipocytes; NK also altered the protein expression of longevity-related genes, such as Sirt1 and AMPKα and increased UCP1 and Cycs, which are involved in mitochondrial generation. These results support the potential of Nrf2 as a possible therapeutic target for delaying aging through the transformation of adipose-phenotype and the effect of longevity factors.
Cost-effectiveness comparison of dalpiciclib and abemaciclib Combined with an aromatase inhibitor as first-line treatment for HR+/ HER2− advanced breast cancer
Authors: Hong Juan , Chen Tujia , Meng Jun , Xia Zhengzheng 
Published: October 2023

Abstract
Background
Dalpiciclib and abemaciclib, both CDK4/6 inhibitors, have been approved by the China National Medical Products Administration for the first-line treatment of postmenopausal women with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2−) advanced breast cancer (ABC). As the first domestically developed CDK4/6 inhibitor in China, there has been no previous economic evaluation of dalpiciclib. This study aimed to assess the cost-effectiveness of dalpiciclib compared to abemaciclib when used in combination with letrozole for the first-line treatment of HR+/HER2 − ABC from the perspective of healthcare payers in China.
Methods
A Markov model with three health states was constructed to evaluate the health and economic outcomes of first-line treatment with dalpiciclib plus letrozole and abemaciclib plus letrozole for HR+/HER2 − ABC. The efficacy data was obtained from the MONARCH3 and DAWNA-2 trials, while utility data was derived from published reports. Quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs) were calculated. Sensitivity analyses were performed to explore variations in the model results.
Results
Compared to abemaciclib plus letrozole, dalpiciclib plus letrozole resulted in 5.13 additional QALYs, with an ICER of $27,305/QALY. At a willingness-to-pay (WTP) threshold of the gross domestic product (GDP) per capita in China for 2022 ($38,223/QALY), the probability of dalpiciclib plus letrozole being cost-effective was 75%. Sensitivity analysis results were consistent with those of the base-case analysis.
Conclusions
From the perspective of Chinese healthcare payers, the combination of dalpiciclib and letrozole appears to be a more cost-effective strategy when compared to abemaciclib plus letrozole for the first-line treatment of patients with HR+/HER2 − ABC in China.
Internally cross-linked wrinkled fibrous silica nanocomposite by bipyridinum dichloride bridge: an efficient catalyst in the synthesis of α,β-unsaturated diketones
Authors: Nasseri Seham , Kiasat Ali Reza 
Published: October 2023

Abstract
In this research, we designed a novel internally cross-linked wrinkled fibrous organo-silica nanocomposite containing bivalent organic cationic bridges in the framework. For this gold, bivalent organosilane bridging agent, Si(OEt)3-BiPy+22Cl--Si(OEt)3 was easily prepared through nucleophilic substitution reaction of (3-chloropropyl) triethoxysilane and bipyridine. In the next step, silanated bivalent cationic bipyridinium dichloride bridge was introduced into the pore walls of dendritic fibrous nanostructured silica through a sol−gel process under open-vessel reflux conditions. The obtained heterogeneous hybrid nanocomposite, KCC-1-Bipy+22Cl-, was characterized by FT-IR, EDX, TGA, and FE-SEM. The rationale was that such wrinkled fibrous, due to its abundant pores and slits, would acts as nanoreactor and would be an excellent catalyst in organic transformation due to the presence of quaternary ammonium units into the pore walls. Owing to the fact that the α-β-unsaturated carbonyl compounds can further be used in the synthesis of valuable intermediates, the catalytic ability of the nanocomposite was tested in the C=C bond formation reaction via Knoevenagel condensation of aldehyde and active methylene compounds under solvent free conditions. In addition to convenience, utilization of the catalyst with high catalytic activity and good reusability, makes this method as an interesting option for facile and efficient synthesis of α,β-unsaturated diketones derivatives.