bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dense video super-resolution time-differential network with feature enrichment module
Authors: Wu Lijun , Ma Yong , Chen Zhicong 
Published: December 2023

Abstract

Video super-resolution is capable of recovering high-resolution images from multiple low-resolution images, where loop structures are a common frame choice for video super-resolution tasks. BasicVSR employs bidirectional propagation and feature alignment to efficiently utilize information from the entire input video. In this work, we improved the performance of the network by revisiting the role of the various modules in BasicVSR and redesigning the network. Firstly, we will maintain centralized communication with the reference frame through the reference-based feature enrichment module after optical flow distortion, which is helpful for handling complex motion, and at the same time, for the selected keyframe, according to the degree of motion deviation of the adjacent frame relative to the keyframe, it is divided into two different regions, and the model with different receptive fields is adopted for feature extraction to further alleviate the accumulation of alignment errors. In the feature correction module, we modify the simple residual block stack to RIR structure, and fuse different levels of features with each other, which can make the final feature information more comprehensive and abundant. In addition, dense connection are introduced in the reconstruction module to promote the full use of hierarchical feature information for better reconstruction. Experimental verification is carried out on two public datasets: Vid4 and REDS4, and the comparative results show that compared with BasicVSR, the PSNR quantitative indexes of the proposed improved model on the two datasets are improved by 0.20dB and 0.33dB, respectively. In addition, from the point of view of visual perception, the model can effectively improve the clarity of the image and reduce artifacts.
Understanding Consumers’ acceptance of organic food in Nagaland, India
Authors: Savi Seyievono , Barua Rashmita 
Published: December 2023

Abstract
There has been an increasing trend in the demand for organic food over the years, owing to its various health benefits and delectable taste. Furthermore, its positive impact on the environment makes it a prevalent choice among consumers. It is important to note that consumer behaviour is critical in the marketing and supply of organic food. Therefore, this study was conducted to look into the many aspects which impact consumers' acceptance of organic food and the values that are associated with it. The factors which influence consumers’ acceptance of organic food, identified from secondary sources, are that organic food is considered healthy, prevents and treats certain diseases, is free from chemical pesticides and synthetic additives, has higher nutritional values, sustains the environment and supports small and local businesses. Data was collected from 214 respondents across five districts of Nagaland using a structured questionnaire. A descriptive research design was employed to collect information and a factor analysis test was performed to determine the factors that contribute to customers' decision to purchase organic food. The study found that among the various factors, that impact consumers' desire to purchase organic food, the health aspect was considered the most important factor. The research is restricted to the state of Nagaland, and the analysis is predicated on the response of the participants.
Case Report: A rare case of anomalous origin of the left coronary artery from the right coronary artery accompanied by left ventricular dysfunction in a young man
Authors: Tu Kexiang , Zhang Yongxu , Wang Yuesong , Pan Jianyuan , Wang Xuezhong 
Published: December 2023

Abstract
Single coronary artery (SCA) is a rare congenital malformation. In this case report, we present the admission of a young man to our department for the establishment of an antihypertensive program. The physical examination and lab tests did not reveal any obvious abnormalities. However, we found an absent left coronary ostium and a normal right coronary artery (RCA), which branched off the left coronary artery to supply the left heart. Further investigations including coronary computed tomography angiography (CCTA) and coronary angiography ruled out coronary heart disease. Transthoracic echocardiography revealed severe left ventricular dysfunction. Through the implementation of effective drug therapy, the blood pressure met the recommended standard and the young man remained in good clinical condition during follow-up.
LRRC8A contributes to neuroinflammation after acute ischemic stroke by interacting with S1PR1 regulating MAPK signal pathway
Authors: Cao Guihua , Guo Jianbin , Yang Kaikai , Xu Rong , Jin Xin , Hou Liming , Bian Peiyu , Fu Wei , Yang Shanru , Li Jinke , Wang Xiaoming 
Published: December 2023

Abstract
Objective and design:
Neuroinflammation exerts important roles in the progression of acute ischemic stroke (AIS). LRRC8A, an essential component of volume-regulated anion channel (VRAC) is expressed predominantly in central nervous system. The aim of this study is to investigate the role of LRRC8A in microglia-mediated neuroinflammation after AIS and the underlying mechanism.
Materials and methods
TTC assay, HE and Nissl staining, RT-PCR, ELISA assay, flow cytometry, Western blot (WB) and immunofluorescence were used to detect the effect of DCPIB on brain injury, neuroinflammation after AIS. Concomitantly, immunofluorescence, FLIM-FRET, and co-immunoprecipitation were used to examine the interplays between LRRC8A and S1P receptor-1(S1PR1).
Results
In mice tMCAO/R model, the administration of LRRC8A-dependent VRAC blocker DCPIB remarkably increased the survival rate and effectively reduced neuronal injury. In addition, DCPIB markedly reversed microglia polarization toward the M1 phenotype and enhanced M2 phenotype. More importantly, LRRC8A physically interacted with S1PR1 via C-terminal leucine-rich repeat domain (LRRD) and DCPIB weakened their interaction. Meanwhile, DCPIB also eliminated the activation MAPK pathway mediated by S1PR1.
Conclusions
The present study revealed a novel regulatory role of LRRC8A in regulating microglia-mediated neuroinflammation through interacting with S1PR1 by LRRD and elucidated a molecular mechanism for the effects of DCPIB on microglia polarization.
TGFBI promotes proliferation and epithelial–mesenchymal transition in renal cell carcinoma through PI3K/AKT/mTOR/HIF-1α pathway
Authors: Zhan Shanzhi , Bai Xiaojie , Zhao Yiqiao , Tuoheti Kuerban , Yisha Zuhaer , Zuo Yingtong , Lu Peixiang , Liu Tongzu 
Published: December 2023

Abstract

Background
Renal cell carcinoma (RCC) is presently recognized as the most prevalent kidney tumor. However, the role and underlying mechanism of action of the conversion factor-inducible protein (TGFBI), an extracellular matrix protein, in RCC remain poorly understood.
Methods
In this study, we employed Western blot, quantitative real-time polymerase chain reaction (qRT-PCR), and immunohistochemistry techniques to assess the expression of TGFBI in RCC tissues or cells. Furthermore, we analyzed the proliferation and migration of RCC cells using CCK8, cloning, scratching, and migration assays. Additionally, we examined apoptosis and cell cycle progression through flow cytometry, analysis. Lastly, we employed gene set enrichment analysis (GSEA) to investigate the biological processes associated with TGFBI, which were subsequently validated.
Results
The findings indicate that TGFBI exhibits significantly elevated expression levels in both renal cell carcinoma (RCC) tissues and cells. Furthermore, the knockdown of TGFBI in SiRNA transfected cells resulted in the inhibition of RCC cell proliferation, migration, invasiveness, apoptosis, and alteration of the cell cycle. Additionally, TGFBI was found to impede the epithelial-mesenchymal transition (EMT) process in RCC cells. Bioinformatics analysis suggests that TGFBI may exert its influence on various biological processes in RCC through the tumor immune microenvironment. Moreover, our study demonstrates that TGFBI promotes RCC progression by activating the PI3K/AKT/mTOR/HIF-1α
Conclusions
Our research indicates that TGFBI exhibits high expression in RCC and facilitate RCC progression and metastasis through various molecular mechanisms. Hence, TGFBI has the potential to be a novel therapeutic target for the diagnosis and treatment of RCC in the future.
Exosomes Originating from Neural Stem Cells Undergoing Necroptosis Participate in Cellular Communication Following Spinal Cord Injury
Authors: Li Shiming , Li Jianfeng , Chen Guoliang , Zhang Penghui , Tong Kuileung , Chen Ningning , Liu Shaoyu 
Published: December 2023

Abstract
In the aftermath of spinal cord injury (SCI), neural stem cells (NSCs) undergo programmed necroptosis, yet the alterations in exosomes and their associated functions remain unexplored. In this study, our data analysis briefly demonstrated that NSCs originate from ependymal cells and experience necroptosis through the classical pathway. Subsequently, NSCs were extracted from embryonic 16-17 mice. We established an in vitro necroptosis model and conducted exosomes extraction. Our findings revealed that necroptosis did not exert a significant impact on the fundamental properties and yield of exosomes. Subsequent to transcriptome sequencing, differentially expressed 108 mRNAs, 104 lncRNAs, 720 circRNAs, and 14 miRNAs were identified, with the first three significantly enriched for the ubiquitin-mediated proteolysis and autophagy signaling pathways. The construction of the competing endogenous RNA network was continued to screen for hubb genes including Tuberous sclerosis 2(Tcs2), Solute carrier family 16 member 3(Slc16a3) and Forkhead box protein P1(Foxp1). Further analysis of cellular communication after SCI revealed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days after SCI through the EGF and MDK signaling pathways, while Slc16a3 participated in cellular communication in the control group and in ependymal cells at 7 days after SCI through the VEGF and MIF signaling pathways. This study introduces novel perspectives on the impacts of necroptosis in SCI.
Analysing the Outbreaks of Leptospirosis After Floods in Kerala, India
Authors: Ifejube Oluwafemi John , Kuriakose Sekhar Lukose , Anish T S , Westen Cees van , Blanford Justine I. 
Published: December 2023

Abstract
A growing number of studies have linked the incidence of leptospirosis with the occurrence of flood events. Nevertheless, the interaction between flood and leptospirosis has not been extensively studied. This study reviews leptospirosis case in relation to different flood occurrences in Kerala, India. Leptospirosis data were obtained for three years: 2017 (non-flood year) and two years with flooding - 2018 (heavy flooding) and 2019 (moderate flooding). The distribution of cases regarding flooding events was assessed through cluster and trend analyses. A statistical comparison was made for cases of each year to ascertain the differences among the cases over flood phases and years. The cases of leptospirosis can be associated with flood events in space and time. The total cases in both 2018 and 2019 increased in the post-flood phase, with the increase in 2018 being more evident. Unlike the 2019 flood, the flood of 2018 is a significant spatial indicator for post flood cases. This study shows that flooding leads to an increase in leptospirosis cases, and there is stronger evidence for increased leptospirosis cases after a heavy flood event than a moderate flooding event. Flood duration may be the most important factor in determining the increase in leptospirosis infections.
Study on the Changes of Cultural and Educational Facilities in Dali City during the Ming and Qing Dynasties
Authors: BAI 小河 
Published: December 2023

Abstract
During the Ming and Qing dynasties, the central government implemented a policy of Bureau-cratization of Native Officers, in order to develop and consolidate the integration of Yunnan with the mainland. And the official facilities, as a key point in the exercise of power by the central government, were closely related to the policy. Taking the construction of cultural and education-al facilities as a starting point, this article attempts to illustrate the impact of this policy in terms of the number of facilities, the spatial distribution, the comprehensive structure and the spread of Confucianism. Shows that: (1) Bureaucratization of Native Officers was implemented in the Dali city, Dali became a representative of the legitimacy of the ruling class in establishing power, and its form and construction gradually converged with that of the Central Plains. (2) The number of facilities gradually increased, the spatial distribution gradually clustered, the integrated struc-ture gradually formed, and Confucianism gradually spread. (3) Through the evolution of these by Circulating Officials, the role of the state functions is reflected, indicating the presence of govern-ment governance and reinforcing the idea of cultural identity.
Cognitive asymmetry in rats in response to emergent vs. disappearing affordances
Authors: Pisula Wojciech , Modlinska Klaudia , Chrzanowska Anna , Goncikowska Katarzyna 
Published: December 2023

Abstract
This study examines the effects of novel environmental changes on the behavior of rats in an experimental chamber. In the first experiment, rats were habituated to a chamber in which all four tunnels were open, and then two tunnels were closed. The rats responded by spending more time near the open tunnels and less time in the central zone. This suggests that the rats are more triggered by the available affordances (open tunnels) than by the environmental change (closed tunnels). In the second experiment, rats were habituated to a chamber with all four tunnels closed, and then two tunnels were opened. The rats responded by spending more time near the newly opened tunnels and less time near the closed tunnels, the central zone, and the transporter. This suggests that rats are more motivated to investigate the environmental change combined with the emergent affordance (opening of the tunnels) than the environmental change alone. In the third experiment, rats were habituated to a chamber with two open tunnels on one side, and two closed tunnels on the other. Then, the arrangement of open and closed tunnels was changed. The rats responded by spending more time near the newly opened tunnels and less time near the central zone. However, they did not spend less time near the newly closed tunnels. This suggests that rats process both the novelty itself and the emergence/disappearance of available affordances. The results are discussed regarding the cognitive asymmetry in the perception of emergent vs. disappearing affordances. It is proposed that the rat's cognitive system is specialized for detecting newly emergent environmental opportunities/affordances.
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP
Authors: abbas ruqaia , Hartmann Oliver , Asiss Dorin Theodora , Abbas Rabab , Kagan Julia , Kim Hyoung-Tae , Oren Moshe , Diefenbacher Markus , Orian Amir , Larisch Sarit 
Published: December 2023

Abstract

Mutations resulting in decreased activity of p53 tumor suppressor protein promote tumorigenesis. P53 protein levels are tightly regulated through the Ubiquitin Proteasome System (UPS). Several E3 ligases were shown to regulate p53 stability, including MDM2. Here we report that the ubiquitin E3 ligase XIAP (X-linked Inhibitors of Apoptosis) is a direct ligase for p53 and describe a novel approach for modulating the levels of p53 by targeting the XIAP pathway. Using in vivo (live-cell) and in vitro (cell-free reconstituted system) ubiquitylation assays, we show that the XIAP-antagonist ARTS regulates the levels of p53 by promoting the degradation of XIAP. XIAP directly binds and ubiquitylates p53. In apoptotic cells, ARTS inhibits the ubiquitylation of p53 by antagonizing XIAP. XIAP knockout MEFs express higher p53 protein levels compared to wild-type MEFs. Computational screen for small molecules with high affinity to the ARTS-binding site within XIAP identified a small-molecule ARTS-mimetic, B3. This compound stimulates apoptosis in a wide range of cancer cells but not normal PBMC (Peripheral Blood Mononuclear Cells). Like ARTS, the B3 compound binds to XIAP and promotes its degradation via the UPS. B3 binding to XIAP stabilizes p53 by disrupting its interaction with XIAP. These results reveal a novel mechanism by which ARTS and p53 regulate each other through an amplification loop to promote apoptosis. Finally, these data suggest that targeting the ARTS binding pocket in XIAP can be used to increase p53 levels as a new strategy for developing anti-cancer therapeutics.
WITHDRAWN: Pigmented paravenous retinochoroidal atrophy caused by VPS13B gene mutations: a case report
Authors: Yang Mengyao , Zheng Xiaoxia , Wang Zekun , Wang Mengdi , Bao Ying , Cui Wenxuan , Wang Hong 
Published: December 2023

Abstract
Background
This study utilizes multimodal imaging to detail a case of pigmented paravenous retinochoroidal atrophy (PPRCA) with a unique genetic backdrop: compound heterozygous mutations in the VPS13B gene.
Case presentation
A 17-year-old male patient presented to our clinic with a chief complaint of bilateral blurred vision persisting for a duration of 2 years. Funduscopic findings showed retinochoroidal atrophy along the retinal veins, bone-spicule retinal pigmentations, and waxy optic disc pallor. Asymmetrical fundus appeared in both eyes. The patient's father had a history of retinitis pigmentosa (RP). Whole-exome sequencing performed on the patient, complemented by Sanger sequencing of his parents' samples, validated the identified variants. The patient inherited a VPS13B c.10691T>C mutation from his mother and a VPS13Bc.1457T>G mutation from his father. Considering the typical clinical features, ophthalmic examination, and genetic analysis, he was diagnosed with PPRCA.
Conclusions
To our knowledge, this is the first reported case of PPRCA resulting from compound heterozygous mutations in the VPS13B gene. It is necessary to perform genomic sequencing on more PPRCA patients to explore the impact of genetic factors on the onset of PPRCA.
Preoperative somatostatin analogues improve visual function in acromegaly patients
Authors: Chen Jinping , Zhang Shaolin , Yao Shun , Wei Xin , Wang Zongming , Mao Zhigang , Wang Haijun 
Published: December 2023

Abstract

Purpose: Our study was to evaluate the effect of preoperative somatostatin analogues(SSA) on acromegaly patients with visual dysfunction.
Methods: An analysis of 31 eyes of 17 acromegaly patients with visual dysfunction was retrospectively conducted, the best corrected visual acuity and visual field (VF) were mainly evaluated. Pared-samples T test and Wilcoxon signed rank test were used to compare the quantitative analysis of VF standard automated perimetry (SAP) mean deviation (MD) values and pattern standard deviation values (PSD) before and after the treatment of SSA. What’s more, the growth hormone (GH), Insulin-Like Growth Factor 1(IGF1) and tumor size of the 17 patients were also analyzed retrospectively.
Results: In total, sixteen patients (94%) presented with tumors of high Knosp grade, the median preoperative treatment duration of SSA was 3 months. The average MD of visual field parameter in SSA treatment was significantly increased (-7.33 vs. -5.45 dB, P＜0.001), the median PSD of visual field parameter in SSA treatment was significantly decreased (6.50 vs. 2.98 dB; P＝0.003). The median GH fell from 41.43 ng/ml to 17.6 ng/ml (P＝0.015), the IGF1 decreased from an average of 812.2 ng/ml to 647.36 ng/ml (P＝0.010). The tumor size including tumor volumes, maximum diameter, maximum vertical diameter also decreased significantly.
Conclusion: This study has demonstrated beneficial effect of preoperative SSA on visual function in acromegaly patients with high Knosp grade, which provided evidence of the preoperative SSA medication on visual function protection, biochemical control, and tumor size reduction.
Analysis of Bangladesh Earthquake Data Using Data Mining Techniques
Authors: Kais Md. Imrul , Mim Md. Tanvir Islam , Hossain Syed Sabit , Ahamed Md. Sazzadur , Tarif Ejaj , Hossain Md. Sarowar 
Published: December 2023

Abstract
Every year many people perish and abate their living due to earthquakes. In this research, former earthquake data between 1918 and 2018 has been collected for the region, Bangladesh which is at 24°00' N and 90°00' E according to latitude and longitude, respectively. These data have been used as a parameter to determine the relationships among several merits of the data set. Therefore, a linear regression algorithm has been exercised for time series forecasting, and the process gives almost a 75-80% success rate in predicting the earthquake zone along with its magnitude. In addition, a statistical map of earthquake magnitudes has been established from the trained data using Weka Explorer, and the evaluation model depends on the clustered instances. The whole analysis has been implemented to develop a website so that people can be aware of earthquakes before the incident. Finally, the place, Snamganj (25°04' 16'' N and 91°24' 13'' E) has been predicted as the riskiest region in Bangladesh for earthquakes on the Sylhet fault zone.
Development and clinical assessment of new topical cream containing postbiotic in the treatment of pediatric atopic dermatitis
Authors: Moazzen Nasrin , Ahanchian Hamid , Golmohammadzadeh Shiva , Delaram Kiana , Sadeghi Tahereh , Masroor Amir Hosein , Khameneh Bahman 
Published: December 2023

Abstract
Introduction:
Atopic dermatitis (AD) is the major common chronic inflammatory dermatologic disorder in children. Postbiotics are bioactive compounds derived from probiotics, inanimate microorganisms, and/or their components. In the current study, we aimed to prepare, characterize, and clinically evaluate postbiotic cream in pediatric patients.
Methods
After preparing different formulations, the formulations were evaluated for stability and physicochemical properties for semi-solids, such as physical properties, viscosity, temperature cycle, and pH. Finally, a formulation that showed better physical properties was chosen for further investigation. The study was performed on patients with AD referred to the outpatient allergy clinic. The primary outcomes were assessed with the SCORAD index and changes in the proportion of children with clinical improvement/no improvement, deterioration, and recurrence rate.
Results
The final formulation's pH was 6.00 ± 0.02. In addition, the centrifugation test showed that this formulation was completely homogeneous after centrifugation. The temperature cycle test indicated no change in the structure of the cream. After a two-month follow-up, the mean SCOARD score was 50 ± 14.5 at baseline and 27.8 ± 10 at the final visit in the postbiotic group. It was also 43 ± 12 at baseline and 28.2 ± 6 at the final visit in the placebo group. After four months, eleven patients had a recurrence in lesions: 2 in the postbiotic group, 6.9% versus 9 in the placebo group, 30%).
Conclusion
This study demonstrated that postbiotic formulation is cutaneously acceptable and showed a clinically significant improvement, especially in long-term follow-up.