bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free Will, Foreknowledge, and Creation: Further Explorations of Kant’s Molinism
Authors: Ertl Wolfgang 
Published: November 2023

AbstractWhile Kant’s position concerning human freedom and divine foreknowledge is perhaps the least Molinist element of his multifaceted take on free will, Kant’s Molinism (minimally defined) is undeniable when it comes to the threat ensuing from the idea of creation. In line with incompatibilism and with careful qualifications in place, he ultimately suggests regarding free agents as uncreated. Given the limitations of our rational insight, this assumption is indispensable for granting that finite free agents can acquire their intelligible characters by themselves. Nonetheless, Kant concedes that creation may, as a matter of fact, be compatible with what for Molina is the pre-volitionality of the counterfactuals of freedom.
Insights Into Lightning K‐Leader Initiation and Development From Three Dimensional Broadband Interferometric Observations
Authors: Jensen Daniel P. , Shao Xuan‐Min , Sonnenfeld Richard G. 
Published: November 2023

AbstractWe report detailed observations of K‐leaders and the activity between them with the three‐dimensional Broadband Interferometric Mapping and Polarization system (BIMAP‐3D) at Los Alamos National Laboratory. It is found that K‐leaders have a general propagation trend of initial acceleration and then gradual deceleration, and the corresponding very high frequency (VHF) radiation power is exponentially correlated with the leader speed. Based on the 3D development and simultaneous electric field change measurement, some simple K‐leaders can be modeled with time‐evolving point charges at the propagating leader tip and at the stationary origin. We found that the charge magnitude increases during the initial acceleration stage and stays relatively constant for the rest of the development. K‐leaders are observed to interact with other branches; the branches affect the leader's propagation speed, and may affect the charge transfer. After the occurrence of a K‐leader, VHF emissions are quenched for several milliseconds. VHF sources then reappear in an impulsive and scattered manner as “twinkling,” and these sources are found not uniquely on the so‐called needles, but also on the main channel. These twinkling sources start near the apparent positive leader tip, and extend back toward the direction of the flash origin at about 105 m/s, while the apparent positive tip continues to extend forward at about 104 m/s. The twinkling extending toward the direction of flash origin appears to initiate the following K‐leader, although it may be interrupted by a K‐leader along a different branch, or simply die out without more K‐leader activity.
Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems
Authors: Barnes Kayla G. , Levy Joshua I. , Gauld Jillian , Rigby Jonathan , Kanjerwa Oscar , Uzzell Christopher B. , Chilupsya Chisomo , Anscombe Catherine , Tomkins-Tinch Christopher , Mbeti Omar , Cairns Edward , Thole Herbert , McSweeney Shannon , Chibwana Marah G. , Ashton Philip M. , Jere Khuzwayo C. , Meschke John Scott , Diggle Peter , Cornick Jennifer , Chilima Benjamin , Jambo Kondwani , Andersen Kristian G. , Kawalazira Gift , Paterson Steve , Nyirenda Tonney S. , Feasey Nicholas 
Published: November 2023

AbstractThe COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020–May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems.
iU-ExM: nanoscopy of organelles and tissues with iterative ultrastructure expansion microscopy
Authors: Louvel Vincent , Haase Romuald , Mercey Olivier , Laporte Marine H. , Eloy Thibaut , Baudrier Étienne , Fortun Denis , Soldati-Favre Dominique , Hamel Virginie , Guichard Paul 
Published: November 2023

AbstractExpansion microscopy (ExM) is a highly effective technique for super-resolution fluorescence microscopy that enables imaging of biological samples beyond the diffraction limit with conventional fluorescence microscopes. Despite the development of several enhanced protocols, ExM has not yet demonstrated the ability to achieve the precision of nanoscopy techniques such as Single Molecule Localization Microscopy (SMLM). Here, to address this limitation, we have developed an iterative ultrastructure expansion microscopy (iU-ExM) approach that achieves SMLM-level resolution. With iU-ExM, it is now possible to visualize the molecular architecture of gold-standard samples, such as the eight-fold symmetry of nuclear pores or the molecular organization of the conoid in Apicomplexa. With its wide-ranging applications, from isolated organelles to cells and tissue, iU-ExM opens new super-resolution avenues for scientists studying biological structures and functions.
A dynamic partitioning mechanism polarizes membrane protein distribution
Authors: Banerjee Tatsat , Matsuoka Satomi , Biswas Debojyoti , Miao Yuchuan , Pal Dhiman Sankar , Kamimura Yoichiro , Ueda Masahiro , Devreotes Peter N. , Iglesias Pablo A. 
Published: November 2023

AbstractThe plasma membrane is widely regarded as the hub of the numerous signal transduction activities. Yet, the fundamental biophysical mechanisms that spatiotemporally compartmentalize different classes of membrane proteins remain unclear. Using multimodal live-cell imaging, here we first show that several lipid-anchored membrane proteins are consistently depleted from the membrane regions where the Ras/PI3K/Akt/F-actin network is activated. The dynamic polarization of these proteins does not depend upon the F-actin-based cytoskeletal structures, recurring shuttling between membrane and cytosol, or directed vesicular trafficking. Photoconversion microscopy and single-molecule measurements demonstrate that these lipid-anchored molecules have substantially dissimilar diffusion profiles in different regions of the membrane which enable their selective segregation. When these diffusion coefficients are incorporated into an excitable network-based stochastic reaction-diffusion model, simulations reveal that the altered affinity mediated selective partitioning is sufficient to drive familiar propagating wave patterns. Furthermore, normally uniform integral and lipid-anchored membrane proteins partition successfully when membrane domain-specific peptides are optogenetically recruited to them. We propose “dynamic partitioning” as a new mechanism that can account for large-scale compartmentalization of a wide array of lipid-anchored and integral membrane proteins during various physiological processes where membrane polarizes.
High-performance van der Waals antiferroelectric CuCrP2S6-based memristors
Authors: Ma Yinchang , Yan Yuan , Luo Linqu , Pazos Sebastian , Zhang Chenhui , Lv Xiang , Chen Maolin , Liu Chen , Wang Yizhou , Chen Aitian , Li Yan , Zheng Dongxing , Lin Rongyu , Algaidi Hanin , Sun Minglei , Liu Jefferson Zhe , Tu Shaobo , Alshareef Husam N. , Gong Cheng , Lanza Mario , Xue Fei , Zhang Xixiang 
Published: November 2023

AbstractLayered thio- and seleno-phosphate ferroelectrics, such as CuInP2S6, are promising building blocks for next-generation nonvolatile memory devices. However, because of the low Curie point, the CuInP2S6-based memory devices suffer from poor thermal stability (<42 °C). Here, exploiting the electric field-driven phase transition in the rarely studied antiferroelectric CuCrP2S6 crystals, we develop a nonvolatile memristor showing a sizable resistive-switching ratio of ~ 1000, high switching endurance up to 20,000 cycles, low cycle-to-cycle variation, and robust thermal stability up to 120 °C. The resistive switching is attributed to the ferroelectric polarization-modulated thermal emission accompanied by the Fowler–Nordheim tunneling across the interfaces. First-principles calculations reveal that the good device performances are associated with the exceptionally strong ferroelectric polarization in CuCrP2S6 crystal. Furthermore, the typical biological synaptic learning rules, such as long-term potentiation/depression and spike amplitude/spike time-dependent plasticity, are also demonstrated. The results highlight the great application potential of van der Waals antiferroelectrics in high-performance synaptic devices for neuromorphic computing.
True prevalence of long-COVID in a nationwide, population cohort study
Authors: Hastie Claire E. , Lowe David J. , McAuley Andrew , Mills Nicholas L. , Winter Andrew J. , Black Corri , Scott Janet T. , O’Donnell Catherine A. , Blane David N. , Browne Susan , Ibbotson Tracy R. , Pell Jill P. 
Published: November 2023

AbstractLong-COVID prevalence estimates vary widely and should take account of symptoms that would have occurred anyway. Here we determine the prevalence of symptoms attributable to SARS-CoV-2 infection, taking account of background rates and confounding, in a nationwide population cohort study of 198,096 Scottish adults. 98,666 (49.8%) had symptomatic laboratory-confirmed SARS-CoV-2 infections and 99,430 (50.2%) were age-, sex-, and socioeconomically-matched and never-infected. While 41,775 (64.5%) reported at least one symptom 6 months following SARS-CoV-2 infection, this was also true of 34,600 (50.8%) of those never-infected. The crude prevalence of one or more symptom attributable to SARS-CoV-2 infection was 13.8% (13.2%,14.3%), 12.8% (11.9%,13.6%), and 16.3% (14.4%,18.2%) at 6, 12, and 18 months respectively. Following adjustment for potential confounders, these figures were 6.6% (6.3%, 6.9%), 6.5% (6.0%, 6.9%) and 10.4% (9.1%, 11.6%) respectively. Long-COVID is characterised by a wide range of symptoms that, apart from altered taste and smell, are non-specific. Care should be taken in attributing symptoms to previous SARS-CoV-2 infection.
Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation
Authors: Burton Alex , Wang Zhong , Song Dan , Tran Sam , Hanna Jessica , Ahmad Dhrubo , Bakall Jakob , Clausen David , Anderson Jerry , Peralta Roberto , Sandepudi Kirtana , Benedetto Alex , Yang Ethan , Basrai Diya , Miller Lee E. , Tresch Matthew C. , Gutruf Philipp 
Published: November 2023

AbstractElectrical stimulation of the neuromuscular system holds promise for both scientific and therapeutic biomedical applications. Supplying and maintaining the power necessary to drive stimulation chronically is a fundamental challenge in these applications, especially when high voltages or currents are required. Wireless systems, in which energy is supplied through near field power transfer, could eliminate complications caused by battery packs or external connections, but currently do not provide the harvested power and voltages required for applications such as muscle stimulation. Here, we introduce a passive resonator optimized power transfer design that overcomes these limitations, enabling voltage compliances of ± 20 V and power over 300 mW at device volumes of 0.2 cm2, thereby improving power transfer 500% over previous systems. We show that this improved performance enables multichannel, biphasic, current-controlled operation at clinically relevant voltage and current ranges with digital control and telemetry in freely behaving animals. Preliminary chronic results indicate that implanted devices remain operational over 6 weeks in both intact and spinal cord injured rats and are capable of producing fine control of spinal and muscle stimulation.
Thermoelectric coupling effect in BNT-BZT-xGaN pyroelectric ceramics for low-grade temperature-driven energy harvesting
Authors: Shen Meng , Liu Kun , Zhang Guanghui , Li Qifan , Zhang Guangzu , Zhang Qingfeng , Zhang Haibo , Jiang Shenglin , Chen Yong , Yao Kui 
Published: November 2023

AbstractPyroelectric energy harvesting has received increasing attention due to its ability to convert low-grade waste heat into electricity. However, the low output energy density driven by low-grade temperature limits its practical applications. Here, we show a high-performance hybrid BNT-BZT-xGaN thermal energy harvesting system with environmentally friendly lead-free BNT-BZT pyroelectric matrix and high thermal conductivity GaN as dopant. The theoretical analysis of BNT-BZT and BNT-BZT-xGaN with x = 0.1 wt% suggests that the introduction of GaN facilitates the resonance vibration between Ga and Ti, O atoms, which not only contributes to the enhancement of the lattice heat conduction, but also improves the vibration of TiO6 octahedra, resulting in simultaneous improvement of thermal conductivity and pyroelectric coefficient. Therefore, a thermoelectric coupling enhanced energy harvesting density of 80 μJ cm−3 has been achieved in BNT-BZT-xGaN ceramics with x = 0.1 wt% driven by a temperature variation of 2 oC, at the optical load resistance of 600 MΩ.
The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation
Authors: Benedum Johannes , Franke Vedran , Appel Lisa-Marie , Walch Lena , Bruno Melania , Schneeweiss Rebecca , Gruber Juliane , Oberndorfer Helena , Frank Emma , Strobl Xué , Polyansky Anton , Zagrovic Bojan , Akalin Altuna , Slade Dea 
Published: November 2023

AbstractTranscription is regulated by a multitude of activators and repressors, which bind to the RNA polymerase II (Pol II) machinery and modulate its progression. Death-inducer obliterator 3 (DIDO3) and PHD finger protein 3 (PHF3) are paralogue proteins that regulate transcription elongation by docking onto phosphorylated serine-2 in the C-terminal domain (CTD) of Pol II through their SPOC domains. Here, we show that DIDO3 and PHF3 form a complex that bridges the Pol II elongation machinery with chromatin and RNA processing factors and tethers Pol II in a phase-separated microenvironment. Their SPOC domains and C-terminal intrinsically disordered regions are critical for transcription regulation. PHF3 and DIDO exert cooperative and antagonistic effects on the expression of neuronal genes and are both essential for neuronal differentiation. In the absence of PHF3, DIDO3 is upregulated as a compensatory mechanism. In addition to shared gene targets, DIDO specifically regulates genes required for lipid metabolism. Collectively, our work reveals multiple layers of gene expression regulation by the DIDO3 and PHF3 paralogues, which have specific, co-regulatory and redundant functions in transcription.
Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment
Authors: Li Ning , Zhu Qin , Tian Yuhua , Ahn Kyung Jin , Wang Xin , Cramer Zvi , Jou Justine , Folkert Ian W. , Yu Pengfei , Adams-Tzivelekidis Stephanie , Sehgal Priyanka , Mahmoud Najia N. , Aarons Cary B. , Roses Robert E. , Thomas-Tikhonenko Andrei , Furth Emma E. , Stanger Ben Z. , Rustgi Anil , Haldar Malay , Katona Bryson W. , Tan Kai , Lengner Christopher J. 
Published: November 2023

AbstractThe initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the complexity of the in vivo microenvironment. Here we predict cancer-TME interactions from single cell transcriptomic maps of both human colorectal cancers (CRCs) and mouse CRC models, ask how these interactions are altered in human tumor organoid (tumoroid) cultures, and functionally recapitulate human myeloid-carcinoma interactions in vitro. Tumoroid cultures suppress gene expression programs involved in inflammation and immune cell migration, providing a reductive platform for re-establishing carcinoma-immune cell interactions in vitro. Introduction of human monocyte-derived macrophages into tumoroid cultures instructs macrophages to acquire immunosuppressive and pro-tumorigenic gene expression programs similar to those observed in vivo. This includes hallmark induction of SPP1, encoding Osteopontin, an extracellular CD44 ligand with established oncogenic effects. Taken together, these findings offer a framework for understanding CRC-TME interactions and provide a reductionist tool for modeling specific aspects of these interactions.
Electrical detection and modulation of magnetism in a Dy-based ferroelectric single-molecule magnet
Authors: Wang Yu-Xia , Su Dan , Ma Yinina , Sun Young , Cheng Peng 
Published: November 2023

AbstractElectrical control of magnetism in single-molecule magnets with peculiar quantum magnetic behaviours has promise for applications in molecular electronics and quantum computing. Nevertheless, such kind of magnetoelectric effects have not been achieved in such materials. Herein, we report the successful realization of significant magnetoelectric effects by introducing ferroelectricity into a dysprosium-based single-molecule magnet through spatial cooperation between flexible organic ligands and halide ions. The stair-shaped magnetization hysteresis loop, alternating current susceptibility, and magnetic relaxation can be directly modulated by applying a moderate electric field. Conversely, the electric polarization can be modulated by applying a small magnetic field. In addition, a resonant magnetodielectric effect is clearly observed, which enables detection of quantum tunnelling of magnetization by a simple electrical measurement. The integration of ferroelectricity into single-molecule magnets not only broadens the family of single-molecule magnets but also makes electrical detection and modulation of the quantum tunnelling of magnetization a reality.
Fast upper-level jet stream winds get faster under climate change
Authors: Shaw Tiffany A. , Miyawaki Osamu 
Published: November 2023

AbstractEarth’s upper-level jet streams influence the speed and direction of travel of weather systems and commercial aircraft, and are linked to severe weather occurrence. Climate change is projected to accelerate the average upper-level jet stream winds. However, little is known about how fast (>99th percentile) upper-level jet stream winds will change. Here we show that fast upper-level jet stream winds get faster under climate change using daily data from climate model projections across a hierarchy of physical complexity. Fast winds also increase ~2.5 times more than the average wind response. We show that the multiplicative increase underlying the fast-get-faster response follows from the nonlinear Clausius–Clapeyron relation (moist-get-moister response). The signal is projected to emerge in both hemispheres by 2050 when considering scenario uncertainty. The results can be used to explain projected changes in commercial flight times, record-breaking winds, clear-air turbulence and a potential increase in severe weather occurrence under climate change.
Both people living in the COVID-19 epicenter and those who have recently left are at a higher risk of loneliness
Authors: Xu Yan-Min , Wang Ming-Fang , Zhong Bao-Liang 
Published: November 2023

AbstractThere is little empirical data on the heightened risk of loneliness among individuals residing in the COVID-19 epicenter or those who have recently left. This study compared the risk of loneliness in individuals residing in Wuhan, the COVID-19 epicenter in China, and those who had recently left during the initial outbreak period to those living in non-epicenter regions. During the COVID-19 outbreak in China in 2020, three samples were obtained using snowball sampling. The samples included 2882 epicenter residents, 1028 left residents, and 2963 non-epicenter residents. Loneliness was assessed using the six-item De Jong Gierveld Loneliness Scale, with a score of two or more indicating the presence of loneliness. 53.5% and 55.2% of epicenter and recently left residents, respectively, experienced loneliness, which was significantly higher than the 43.9% observed in non-epicenter residents. After adjusting for covariates, the risk of loneliness remained statistically significant for both epicenter and left residents (OR = 1.35, P < 0.001 and OR = 1.20, P = 0.017, respectively), when compared to non-epicenter residents. Individuals residing in the COVID-19 epicenter, as well as those who have recently left, are at a heightened risk of loneliness during the outbreak. These individuals need psychosocial support to mitigate their risk of loneliness and promote their psychological wellbeing.
Electrochemical properties of a novel EDLC derived from plasticized biopolymer based electrolytes with valuable energy density close to NiMH batteries
Authors: Aziz Shujahadeen B. , Brza Mohamad A. , Abdulwahid Rebar T. , Hassan Jamal , Tahir Hawzhin B. , Al-Saeedi Sameerah I. , Abdullah Ranjdar M. , Hadi Jihad M. 
Published: November 2023

AbstractThis study introduces a novel system of solid electrolytes for electrical double-layer capacitors (EDLCs) utilizing biopolymer electrolytes with high energy density comparable to NiMH batteries. To prepare the electrolytes, a proton-conducting plasticized chitosan: poly(2-oxazoline) (POZ) with good film-forming properties was fabricated using a solution casting technique, and ammonium trifluoromethanesulfonate (NH4CF3SO3) salt was employed as a proton provider. Various glycerol concentrations were incorporated into the chitosan:POZ: NH4CF3SO3 system to enhance the ionic conductivity and fully transparent films were obtained. The impedance technique was utilized to determine the conductivity and measure the diffusion coefficient, mobility, and number density of ions. The electrochemical measurements, including linear sweep voltammetry (LSV) and cyclic voltammetry (CV), validated the high performance of the system. The EDLC was examined using galvanostatic charge-discharge (GCD) equipment, and the results revealed an energy density of 43 Wh/kg, specific capacitance of 300 F/g, and power density of 1800 W/kg over 500 cycles. These findings suggest that it is plausible to develop EDLCs that resemble batteries, making them a more desirable energy storage option for the industry.