bluuebunny/crossref_metadata_2025_split huggingface dataset:
Igniting a movement in a dual‐licensed dental workforce: The Minnesota model
Authors: Brickle Colleen M. , Jacobi Deborah A. , Larkin Clare E. 
Published: October 2023

AbstractAimsIncreased awareness of oral health disparities in the United States has highlighted the need to expand the workforce and access to both primary and preventive dental care. Achieving the goal of oral health equity will require dental team members with appropriate clinical skills dedicated to reaching historically marginalized populations through intra‐ and interprofessional practice.Materials and MethodsCollective efforts by healthcare advocates in Minnesota led to legislation that created a dental hygiene‐based workforce model inspired by the vision and foresight of the American Dental Hygienists' Association's ‘Advanced Dental Hygiene Practitioner’.ResultsIn July 2023, there were 141 licensed dental therapists and 99 certified advanced dental therapists, the majority dually licensed as dental hygienists/dental therapists, providing primary care services in a variety of settings throughout the state. Current data confirm the contributions of this workforce model to increasing access to primary oral health care for Minnesotans across the lifespan.ConclusionsWhile challenges remain, new opportunities are emerging for dual‐licensed dental hygienists/dental therapists to reach intended populations. Minnesota's challenges and successes with the authorization and implementation of a dental hygiene‐based workforce model can serve to assist others in developing their own intra‐ and interprofessional oral health care practitioners.
Long‐pulsed 1,064‐nm gallium arsenide laser surgical device treatment for improving symptoms of onychomycosis: a comparative analysis
Authors: Choi Sun Young , Shin Sun Hye , Seok Joon , Ko Eun Jung , Yoo Kwang Ho , Kim Beom Joon 
Published: October 2023

AbstractBackgroundOnychomycosis is the most common infective nail disease, and treatment includes topical and systemic antifungal medications. Recently, laser therapy has emerged as a therapeutic option for patients who are unable to take oral antifungal agents. We investigated the effectiveness and safety of a novel long‐pulsed 1,064‐nm gallium arsenide (GaAs) laser surgical device for onychomycosis.MethodsThis 24‐week single‐center, single‐blind, active‐controlled exploratory clinical study comparatively evaluated the long‐pulsed 1,064‐nm GaAs laser (Healer1064) with the short‐pulsed Nd:YAG laser surgical device in 20 participants randomly assigned to receive either test or control treatment at 4‐week intervals during the 12‐week treatment period. The rate of clinical improvement was evaluated by two independent dermatologist evaluators using the Onychomycosis Severity Index‐score (OSI‐score) and Turbidity Scale with standard photographs. Overall improvement and patient satisfaction were evaluated. Safety evaluation included pain intensity and adverse events.ResultsIn 44 (test: 25; control: 19) cases in 19 participants who completed treatment, the clinical improvement rate in the test and control groups was 52.00% (13/52 cases) and 44.44% (9/19 cases), respectively, with significantly lower pain scores in the test than the control group for every treatment visit (P < 0.05) and without severe adverse events.ConclusionsThe novel long‐pulsed 1,064‐nm GaAs laser showed greater, albeit nonsignificant, clinical improvement and was associated with less pain during treatment. Thus, the Healer1064 can provide satisfactory treatment outcomes through painless and effective improvement in onychomycosis symptoms.
Effect of intramedullary nail fixation and internal plate fixation in distal tibia fracture surgery on post‐operative wound infection in patients: A meta‐analysis
Authors: Lv Changli , Jiang Cuifeng , Lv Weifeng , Zhang Shanshan , Li Chengxue 
Published: October 2023

AbstractDistal tibial fracture is the most commonly seen type of fracture of the lower extremities. Both intramedullary nail fixation (INF) and plate fixation (PF) have been used to treat distal tibial fractures, but the best way to treat them is still in dispute. The purpose of this meta‐analysis is to compare INF versus PF fixation with respect to the incidence of injury. For studies that have been published between inception and June 2023, a systematic review has been carried out on PubMed, Embase, Cochrane Library and Web of Scientific databases. All of the trials that looked at INF and PF‐related complications were enrolled. Data from the 13 primary results were analysed with RevMan 5.3. The meta‐analyses comprised 13 randomized controlled trials (RCTs). INF indicates that there is a tendency for patients with distal tibia fractures to reduce the risk of operative site infection (odds ratio [OR], 2.09; 95% confidence interval [CI], 1.40, 3.13; p = 0.0003) after surgery compared with PF. INF resulted in a reduction in total wound complications (OR, 14.20; 95% CI, 1.81, 111.57; p = 0.01) but shortened operation time (mean difference, 13.03; 95% CI, 2.08, 23.99; p = 0.02). In view of these findings, INF seems to be a preferred method of surgery for the treatment of distal tibial fractures with respect to the reduction of post‐operative wound complications.
Opening Up Opportunities: Trainee Teachers Experiences of Teaching Pupils with Visual Impairment
Authors: Dunn Harriet 
Published: October 2023

AbstractPostgraduate Certificate in Education (PGCE) secondary art and design trainees facilitated an art education project for pupils at a specialist school for visual impairment (VI) in the Northwest of England. This paper focuses on the ways in which the art education project was designed to better prepare PGCE trainees for working with pupils with VI. There is an exploration of a series of reflections at the end of the art education project and again upon completion of the PGCE course. Feedback provided by PGCE trainees indicated the ways they were able to transfer the skills learnt regarding teaching pupils with VI into practice, as they embark upon their careers. Existing literature highlights variation across initial teacher training (ITT) in relation to what is taught regarding special educational needs, this is generally due to time constraints on one year ITT courses. The findings indicate these experiences have implications for practice. through following their journey, initially PGCE trainees were apprehensive about working with pupils with VI. However, facilitating the art education project enabled PGCE trainees to become more confident working with pupils. PGCE trainees were able to develop as teachers.
Friction and Failure in the Secondary Art Classroom: Cultivating Decolonial Transformative Pedagogies of Hope
Authors: Stanhope Clare 
Published: October 2023

AbstractThis article explores how the colonisation of womens bodies, as perpetuated through the art trope of the female nude, has constructed a specific bodily ideal that still resonates and informs how we view women's bodies in contemporary life. I address how the same narratives that restrict our understanding of the female body, also restrict our understanding of drawing. I share part of my PhD practice research: PhEminist Skins of Resistance, a project conducted in my school, which sought to decolonise the legacy of the female nude and support the empowerment of the young women artists who populate the classrooms in which I teach. Theoretically informed by PhEmaterialism (feminist posthumanism and new materialism research methodologies in education), material agency is positioned as vital to an embodied learning experience and situates how I (re)position life drawing as a tool to re‐imagined and disrupt heteronormative and raced colonial imaginings of the female body. I further explore how this project created space within the secondary art classroom for creative‐activism, and the power of such learning environments to reach out beyond the constraints of neo‐liberal educational structures and inspire transformative pedagogies of hope.
Eristic Legitimation of Controversial Managerial Decisions
Authors: Kurdoglu Rasim Serdar , Islam Gazi 
Published: October 2023

AbstractThis paper investigates the eristic legitimation of managerial decisions – managerial interactions to win without reasoned persuasion of the counterparty – in the context of career‐advancement disputes. This mode of legitimation can be ethically questionable, particularly when powerful managers have the licence for it, while less powerful subordinates may have ‘no other choice’ than reasoned persuasion to address their concerns. The present study involves two sets of interviews to explore eristic legitimations and associated moral and political processes. The first involves former employees who had career advancement disputes with their former managers, and the second, HR professionals with expertise in dealing with employee complaints. Our analysis suggests that managing unfairness concerns can be destructive when managerial authorities argue eristically by exploiting ambiguities around performance, tasks, goals and moral principles. The novelty of this study is that it explores how ambiguities shape managerial handling of employees’ justice concerns and how eristic legitimations during ethical decision‐making can have deleterious consequences for organizations and individual careers. While this study contributes to research on the rhetorical strategies of managers, it has important implications for interactional justice and ethical decision‐making research.
Causal effects of life course adiposity on temporomandibular disorders: A Mendelian randomization study
Authors: Chen Xin , Cheng Zheng , Xu Junyu , Wang Qianyi , Zhao Zhibai , Jiang Qianglin 
Published: October 2023

AbstractBackgroundPrevious studies investigated the associations between obesity and temporomandibular disorders (TMDs), but the evidence for the causal inferences was unclear.ObjectiveWe aimed to investigate the causal link between life course adiposity and TMDs.MethodsMendelian randomization (MR) studies were performed using genetic instruments for birth weight (BW) (N = 261 932), childhood body mass index (BMI) (N = 39 620), childhood body size (N = 454 718), adult BMI (N = 99 998), body fat percentage (N = 454 633) and TMDs (N = 211 023). We assessed the overall effect of each life course adiposity factor via inverse‐variance weighted (IVW), weighted median, and MR‐Egger methods and performed extensive sensitivity analyses. Additionally, multivariable MR was conducted to evaluate the direct and indirect effects of childhood BMI on TMDs while accounting for BW and adult BMI, and vice versa.ResultsUnivariable MR analyses revealed a causal effect of low childhood adiposity on an increased risk of TMDs (childhood BMI: IVW OR: 0.65, 95% CI: 0.54–0.78,p < .001; childhood body size: IVW OR: 0.56, 95% CI: 0.43–0.73,p < .001). No causal association existed between genetically predicted BW, adult BMI, or body fat percentage and TMDs. In the multivariable MR analyses, the effects of childhood BMI on TMDs occurrence remained significant and direct, even after adjusting for BW and adult BMI (multivariable IVW OR: 0.78, 95% CI: 0.61–0.99,p = .048). No pleiotropy and heterogeneity were detected (p > .05).ConclusionLow childhood BMI might causally increase the risk of TMDs through a direct pathway.
Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma
Authors: Yuan Dong , Li Xin‐Qiang , Qu Fang‐wen , Wang Yue 
Published: October 2023

AbstractBackgroundOral squamous cell carcinoma is an increasingly prevalent cancer type characterized by high incidence and mortality rates. Its early detection is challenging, primarily because of the absence of early molecular markers. Cuproptosis is a novel regulatory mechanism of cell death with implications in various cancers. In this study, we aimed to study cuproptosis‐related genes in oral squamous cell carcinoma to identify their prognostic value.MethodsBy analyzing genomic, bulk RNA‐seq, and single‐cell RNA‐seq data, we investigated 13 cuproptosis‐related genes in The Cancer Genome Atlas‐Oral Squamous Cell Carcinoma dataset and Gene Expression Omnibus repository (GSE172577).ResultsATP7A, ATP7B, and DLST were the most frequently mutated genes, with nine of our studied genes associated with overall survival. Single‐cell analysis was conducted to identify cuproptosis‐related tumor cells in oral squamous cell carcinoma, which revealed two distinct patterns based on the expression of cuproptosis‐related genes. These patterns exhibit differences in genetic alterations and tumor immune microenvironment. Finally, we developed a cuproptosis index using a random forest algorithm based on cuproptosis pattern‐related genes in which higher levels were linked to poorer prognosis.ConclusionOur findings provide valuable insights into the mechanisms underlying oral squamous cell carcinoma‐associated cuproptosis.
Volatiles, vesicles, and vugs: Unraveling the magmatic and eruptive histories of Steno crater basalts
Authors: Wilbur Z. E. , Barnes J. J. , Eckley S. A. , Ong I. J. , Brounce M. , Crow C. A. , Erickson T. , Kent J. J. , Boyce J. W. , Mosenfelder J. L. , Hahn T. , McCubbin F. M. , Zega T. J. ,   the ANGSA Science Team
Published: October 2023

AbstractIn 1972, Apollo 17 astronauts returned 170.4 kg of lunar material. Within 1 month of their return, a subset of those samples was specially curated with the forethought that future analytical techniques would offer new insight into the formation and evolution of the Moon. Of interest in this work is sample 71036, a basalt collected from the rim of Steno crater in the Taurus–Littrow Valley, which was stored frozen and was processed and released for study 50 years later. We report, for the first time, the detailed mineralogy and petrology of 71036 and its companion samples 71035, 71037, and 71055 using a novel combination of 2‐D and 3‐D methods. We investigate lunar volatiles through in situ measurements of apatite and 3‐D measurements of vesicles to understand the degassing histories of the Steno crater basalts. Our coupled 2‐D petrography and 3‐D tomography data sets support a model of the Steno crater basalts crystallizing in the upper crust of a mare lava flow. Apatite F and OH chemistry and the late‐stage deformation of voids and formation of smaller vesicles provide evidence supporting coeval degassing of volatiles and crystallization of mesostasis apatite in Apollo 17 basalts. This work helps to close knowledge gaps surrounding the origin, magmatic evolution, emplacement, and crystallization history of high‐titanium basalts.
Psychometric validation of the Chinese digital health literacy instrument among Chinese older adults who have internet use experience
Authors: Xie Luyao , Hu Huahua , Lin Jiaer , Mo Phoenix K. H. 
Published: October 2023

AbstractIntroductionIn this digital age, the Internet has become a major source of health information, and electronic health (eHealth) literacy becomes increasingly important for older individuals to properly use the extensive eHealth resources for self‐care. A valid and reliable tool for assessing older people's eHealth literacy would help healthcare workers identify those disadvantaged groups in digital health and provide relevant health education.ObjectivesThis study aimed to evaluate the psychometric properties of the Chinese version of DHLI in assessing eHealth literacy among older adults in China.MethodsA web‐based, cross‐sectional study was conducted among 277 Chinese older adults from September to November 2021. Two weeks after the first completion, 62 of them answered the C‐DHLI again. The reliability (e.g. internal consistency and test–retest reliability), factorial structure and validity (i.e. content validity and convergent validity) of the C‐DHLI were evaluated based on the survey data.ResultsThe results demonstrated good internal consistency (Cronbach's alpha: 0.94) and test–retest reliability (total intraclass correlation coefficient [ICC]: 0.94) of the C‐DHLI. Principal component analysis revealed that the 18 items of C‐DHLI loaded on three factors, accounting for 74.69% of the total variance; CFA supported its three‐factor structure with good model fits. Convergent validity was examined by the significant associations between C‐DHLI and C‐eHEALS (r = 0.61), health literacy (r = 0.56), and whether having used the Internet for health information (ρ = 0.43) (ps <.001). A cut‐off score of 45 was recommended for determining higher and lower literacy using the C‐DHLI, with the area under curve of 0.82 (95% CI = 0.77–0.88).Conclusions and Implications for PracticeThe C‐DHLI showed good psychometric performance in assessing eHealth literacy among Chinese older adults. The findings can support healthcare professionals to effectively measure eHealth literacy among older adults and conduct tailored eHealth interventions or training.
Reducing chlorophyll levels in seed‐filling stages results in higher seed nitrogen without impacting canopy carbon assimilation
Authors: Cho Young B. , Boyd Ryan A. , Ren Yudong , Lee Moon‐Sub , Jones Sarah I. , Ruiz‐Vera Ursula M. , McGrath Justin M. , Masters Michael D. , Ort Donald R. 
Published: October 2023

AbstractChlorophyll is the major light‐absorbing pigment for plant photosynthesis. While evolution has been selected for high chlorophyll content in leaves, previous work suggests that domesticated crops grown in modern high‐density agricultural environments overinvest in chlorophyll production, thereby lowering light use and nitrogen use efficiency. To investigate the potential benefits of reducing chlorophyll levels, we created ethanol‐inducible RNAi tobacco mutants that suppress Mg‐chelatase subunit I (CHLI) with small RNA within 3 h of induction and reduce chlorophyll within 5 days in field conditions. We initiated chlorophyll reduction later in plant development to avoid the highly sensitive seedling stage and to allow young plants to have full green leaves to maximise light interception before canopy formation. This study demonstrated that leaf chlorophyll reduction >60% during seed‐filling stages increased tobacco seed nitrogen concentration by as much as 17% while canopy photosynthesis, biomass and seed yields were maintained. These results indicate that time‐specific reduction of chlorophyll could be a novel strategy that decouples the inverse relationship between yield and seed nitrogen by utilising saved nitrogen from the reduction of chlorophyll while maintaining full carbon assimilation capacity.
The FLOWERING LOCUS T 5b positively regulates photoperiodic flowering and improves the geographical adaptation of soybean
Authors: Su Qiang , Chen Li , Cai Yupeng , Wang Liwei , Chen Yingying , Zhang Jialing , Liu Luping , Zhang Yan , Yuan Shan , Gao Yang , Sun Shi , Han Tianfu , Hou Wensheng 
Published: October 2023

AbstractPlants can sense the photoperiod to flower at the right time. As a sensitive short‐day crop, soybean (Glycine max) flowering varies greatly depending on photoperiods, affecting yields. Adaptive changes in soybeans rely on variable genetic loci such as E1 and FLOWERING LOCUS T orthologs. However, the precise coordination and control of these molecular components remain largely unknown. In this study, we demonstrate that GmFT5b functions as a crucial factor for soybean flowering. Overexpressed or mutated GmFT5b resulted in significantly early or later flowering, altering expression profiles for several downstream flowering‐related genes under a long‐day photoperiod. GmFT5b interacts with the transcription factor GmFDL15, suggesting transcriptional tuning of flowering time regulatory genes via the GmFT5b/GmFDL15 complex. Notably, GmFT5a partially compensated for GmFT5b function, as ft5a ft5b double mutants exhibited an enhanced late‐flowering phenotype. Association mapping revealed that GmFT5b was associated with flowering time, maturity, and geographical distribution of soybean accessions, all associated with the E1 locus. Therefore, GmFT5b is a valuable target for enhancing regional adaptability. Natural variants or multiple mutants in this region can be utilized to generate optimized soybean varieties with precise flowering times.
Risk factors and clinical characteristics of acute and chronic cutaneous graft‐versus‐host disease in pediatric patients undergoing hematopoietic stem cell transplantation
Authors: González‐Cruz Carlos , Repiso Trinidad , Ferrándiz‐Pulido Carla , Navarro Alexandra , García‐Patos Vicente 
Published: October 2023

AbstractAcute and chronic cutaneous graft‐versus‐host disease (GVHD) are common complications following hematopoietic stem cell transplantation (HSCT) in pediatric patients. In this retrospective study, we explored the risk factors and clinical characteristics of acute and chronic cutaneous GVHD in a case series of children undergoing HSCT at a tertiary referral hospital. We found that 36% of acute cutaneous GVHD was severe and these patients were more likely to have an unrelated donor, and that children with acute cutaneous GVHD who progressed to chronic cutaneous GVHD had a higher proportion of malignant diseases, total body irradiation, and bronchiolitis obliterans compared to those who did not progress to chronic cutaneous GVHD. Our study highlights the importance of identifying and monitoring these high‐risk patients to improve the clinical management and outcomes of cutaneous GVHD in pediatric HSCT recipients.
Donepezil attenuates inflammation and apoptosis in ulcerative colitis via regulating LRP1/AMPK/NF‐κB signaling
Authors: Li Angqing , Zhang Junyi , Chen Ke , Wang Jian , Xu Aman , Wang Zhengguang 
Published: October 2023

AbstractThis article focuses on the specific effects and mechanisms of donepezil (DNPZ) hydrochloride on inflammation and apoptosis in ulcerative colitis (UC). In vivo and in vitro models of UC were established using dextran sodium sulfate (DSS)‐induced mice and NCM460 cells, respectively. Following oral administration of DNPZ, body weight, disease activity index (DAI) scores and colon lengths of mice were recorded. Histopathological damage was detected employing hematoxylin and eosin (H&E) staining. Inflammatory factors were tested using enzyme‐linked immunosorbent assay and quantitative reverse transcription polymerase chain reaction, respectively. Apoptosis was estimated utilizing terminal deoxynucleotidyl transferase dUTP nick‐end labeling and western blot. Low‐density lipoprotein receptor‐related protein 1 (LRP1)/AMP activated protein kinase (AMPK)/nuclear factor‐κB (NF‐ κB) signaling proteins were detected utilizing western blot. NCM460 cell viability was assessed by cell counting kit (CCK)‐8. We found that DNPZ partially restored body weight, reduced DAI scores and attenuated intestinal pathological damage in DSS‐induced mice. Additionally, inflammatory factors decreased significantly after DNPZ treatment, accompanied by reduced apoptosis level. Phosphorylation (p)‐AMPK increased and p‐p65 decreased after DNPZ treatment, whereas LRP1 knockdown showed the opposite effect. Moreover, DNPZ treatment greatly restored NCM460 cell viability after DSS stimulation. DNPZ attenuated DSS‐induced inflammation and apoptosis in NCM460 cells, which was reversed by LRP1 knockdown. In summary, DNPZ hydrochloride attenuates inflammation and apoptosis in UC via LRP1/AMPK/NF‐κB signaling.