bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common Migraine Attack: Platelet Modifications Are Mainly Due to Plasma Factor(s)
Authors: Launay J.M. , Pradalier A. 
Published: June 2005

SYNOPSISVarious biochemical determinations were performed on plasma and platelets of unmedicated common migrainous patients, either during crisis or in attack‐free intervals. The main change occurring during crisis appears to be a release of dense bodies and a‐granules, with a concomitant decrease of platelet serotonin uptake but without important modifications of the platelet metabolism of bioamines. From the data concerning platelet serotonin uptake, a slight platelet defect cannot be excluded. Nevertheless, the role of unidentified plasma factor(s) appears to be much more important in the genesis of the biochemical changes observed during common migraine attack.
Relationship Between HLA System in Cluster Headache and Clinical Response to Lithium Therapy
Authors: Giacovazzo M. , Martelletti R , Romiti  , Gallo M.F. , Iuvara E. 
Published: June 2005

SYNOPSISThe relationship between the major system of histocompatibility antigens and cluster headache has already been studied by our group, and decreased frequency of HLA‐B14 antigen shown in cluster headache patients in comparison to a control population.The therapy of cluster headache with lithium salts is already widely acclaimed; nevertheless there are patients who derive no benefit or must suspend treatment due to side‐effects. Thus we wanted to study the relationship between genetic markers of patients with the illness and the therapeutic efficacy of lithium salts.35 episodic cluster headaches have been studied; they had been already typed for the HLA antigens. The patients were treated with lithium carbonate for a period of 3 months. As parameters for evaluation of the efficacy of treatment, the headache index ratio, the wake‐sleep rhythm and the pupil diameter measurement were studied.Statistical evaluation was made and it was possible to separate two subgroups of patients: “responders” and “non responders” to lithium therapy. The phenotypical frequencies in the two subgroups was analyzed using the X2 test.A higher frequency of HLA‐B18 antigen (23.8% vs 0%; p< 0.0005; pc<0.06) and of HLA‐A9 antigen (42.9% vs 14.3%) showed in the “responders” group. In the “non responders” group was found a higher frequency in HLA‐A1 antigen (35.7% vs 14.3%).
Non‐Migrainous Headache and Transient Neurological Deficits
Authors: Neufeld Miriam Y. , Nisipanu Puiu F. , Korczyn Amos D. 
Published: June 2005

SYNOPSISTwo young patients experienced transient and recurrent neurological deficits, associated with headache, without fever, signs of meningeal irritation or systemic disease.This situation in a young patient is usually a manifestation of migraine, but none of our patients had a history f vascular headache. Lumbar puncture was performed, and CSF pleocytosis found in both cases. These cases may represent a poorly recognized benign syndrome of transient neurological signs of headache and a sterile inflammatory reaction in the CSF.
Pain Response to Voluntary Muscle Tension Increases and Biofeedback Efficacy in Tension Headache
Authors: Borgeat François , Elie Robert , Larouche Léon M. 
Published: June 2005

SYNOPSISThe hypothesis that patients reporting an association between head pain and voluntary muscle tension increases could react more positively to EMG biofeedback was evaluated in 33 tension headache sufferers involved in a program of six training sessions and of a follow‐up two months later. These patients were taught to increase their frontal muscle tension over 10 μvolts through biofeedback for a period of one minute at the first session and of two minutes at the second one. According to their subjective pain response, 14 patients were considered to show a positive association between head pain and muscle tension increases while the 19 others did not show such an association. The group of patients with a positive association between head pain and muscle tension showed a rapid symptomatic improvement which was partially lost as the training progressed, while the other reported a more linear gradual improvement. At follow‐up, there was no difference in headache, drug usage and frontal EMG between the two groups. The differences in the shapes of the symptomatic responses are discussed in terms of patients’ expectations from the training.
Lithium‐Triggered Chronic Cluster Headache
Authors: Brainin M. , Eisenstädter A. 
Published: June 2005

SYNOPSISLithium carbonate, usually helpful in the treatment of cluster headache, showed a paradoxical effect in a patient now being seen for over one year. Chronic cluster headache developed after she had been taking lithium for more than eight years for psychiatric indications. Only by total discontinuation of lithium therapy could a complete remission of the headaches be brought about. This effect was observed repeatedly. It is suggested that a chronic effect of lithium at the receptor sites of the central trigeminovascular pathways plays a role.
Basilar Migraine Manifesting as Transient Global Amnesia in a 9‐Year‐Old Child
Authors: Amit R. , Shapira Y. , Flusser H. , Aker M. 
Published: June 2005

SYNOPSISA case of transient global amnesia in a nine year old child with a history of recurrent episodes of vertigoand a family history of migraine headache is described. The possibility that acute confusional state inchildren, presenting as transient global amnesia may represent a variant of basilar migraine is discussed.
The Headache Scale: an Examination of its Reliability and Validity
Authors: Jahanshahi M. , Hunter M. , Philips C. 
Published: June 2005

SYNOPSIS360 Migraine and tension headache sufferers attending a specialist headache clinic completed theHeadache Scale (HS), the McGill Pain Questionnaire (MPQ) and the Pain Behaviour Checklist. Mood andpersonality were also assessed. The test‐retest reliability of the HS over a one week period was examinedand found to be adequate. Cluster analysis of the HS adjectives resulted in 5 clusters labelled tight, sharp,dull (sensory), discomfort and autonomic (affective). When the severity of headaches was partialled out, asensory and an affective cluster corresponding to the two major components of subjective pain experiencewere obtained. The concurrent validity of the HS was further demonstrated by its having an identicalpattern of association as the MPQ to the Pain Behaviour Checklist, the Wakefield Depression Inventory andthe Eysenck Personality Questionnaire. Scores of the classical and common migraineurs and tensionheadache sufferers on the HS were quantitatively but not qualitatively different. Situations in which the HSmay be used instead of the MPQ are outlined and suggestions for further examination of the validity of theHS are made.
Multiple Headaches in a Case of Multiple Personality Disorder
Authors: Packard Russell C. , Brown Frank 
Published: June 2005

SYNOPSISA female with multiple personality disorder (MPD) was referred for treatment of several different anddistinct headache problems. This case is presented in detail and the literature is reviewed in regard toheadaches occurring in cases of MPD.In an extensive review of 52 previously reported cases of MPD, headaches was the most frequent somaticcomplaint, occurring in over 60%. Headaches previously reported, however, have never been well definedas to etiology, type or treatment. This paper addresses these areas and the problems involved in makingsuch determinations in this unusual personality disorder.The curious clinical observations about the headaches observed in this case of MPD suggest that thisgroup of headache patients might prove to be a unique population for further study, especially in regard tosolving some of the biochemical and emotional mechanisms of headache, and their possible interactions.
The Diagnostic Value of High Resolution Computerized Tomography in Post‐traumatic Head Pain Patients
Authors: Tilds Barry N. , Miller Peter R. , Guidice Mary Ann 
Published: June 2005

SYNOPSISHigh resolution CT scanning in patients with post‐traumatic head pain is superior to conventional radiography fordetecting fractures and other lesions of the facial structures. This is an important consideration, since suchlesions may be responsible for the post‐traumatic pain. Direct axial and coronal scanning is adequate fordiagnosis in most cases; multiplanar reconstructions can be done to obtain sagittal and other views. The radiationdose and cost of CT are comparable to those of conventional tomography.
Propranolol in the Prophylaxis of Migraine
Authors: Nadelmann J.W. , Phil. M. , Stevens J. , Saper J.R. 
Published: June 2005

SYNOPSISThis 34‐week, placebo‐controlled, single crossover study with a double‐blind randomized treatment sequence evaluated the effects of propranolol as a prophylactic agent in individualized doses ranging from 60–320 mg/day given to 62 patients who had common and/or classic migraine. Variables reflecting efficacy were the frequency, severity, and persistency of acute migraine attacks expressed as Headache Unit Index (HUI) and the therapeutic medication required for acute attacks during the study expressed as the Relief Medication Unit Index (RMUI). Both HUI and RMUI were significantly reduced from baseline after the six weeks of propranolol titration (p<0.0001) reflecting fewer and/or less severe headaches. During the crossover treatment periods, propranolol, in comparison with placebo, was significantly more effective in the reduction of HUI (p<0.01) and RMUI (p<0.05). Data at the end of the dose finding (titration) period were analyzed separately for patients whose final prescribed doses were 60‐240 mg or 320 mg/day propranolol. Significant reductions in HUI and RMUI (p< 0.0001) were shown at this time at each dose level. At all dose levels, propranolol was well tolerated. This was the first study in which the propranolol dose for migraine extended above the usual recommended 240 mg/day, i.e., up to 320 mg/day. This higher dose was administered if the drug had been well tolerated, even if only one headache in 2 weeks occurred at lower doses. The data suggest that there is an option to prescribe propranolol at higher doses as a preventive measure, thus reducing the need for ancillary medications.
Inpatient Treatment of Headache: Long‐Term Results
Authors: Diamond Seymour , Freitag Frederick G. , Maliszewski Michael 
Published: June 2005

SYNOPSISIn certain refractory cases of headache, inpatient therapy in a headache treatment unit may prove beneficial. Strict criteria for admission to this unit have been developed. To ascertain the long‐term benefits of treatment, a survey was sent to 372 consecutive patients. A 41% response rate was achieved. Fifty‐four percent of the patients had a greater than 50% reduction in headache unit index at the time of the survey and 59.6% had a greater than 50% reduction in the corrected headache unit index. Approximately 10% of those responding to the survey had become and remained completely headache‐free. Medical management and non‐drug therapies such as biofeedback and dietary instruction were viewed as being the most important treatment modalities by the patients. Psychological modalities were of benefit to 72% of the patients and biofeedback was useful to 54% of the patients. These results prompt us to believe that the multidisciplinary inpatient treatment of headache is beneficial to the majority of patients whose headaches have been refractive to traditional outpatient treatment.
Observations on Prodromes of Classic Migraine in a Headache Clinic Population
Authors: Bana Dhirendra S. , Graham John R. 
Published: June 2005

SYNOPSISProdromes of classic migraine were retrospectively studied from the records of 325 patients as regards their type, number, duration, frequency and sidedness in relation to the headache phase. We conclude:1. Prodromes can affect any of the senses, but most commonly affect the visual field.2. When more than one prodrome was present, the most common combinations were: Visual + Sensory for two prodromes; visual + sensory + speech for three prodromes; and visual + sensory + speech + motor for four prodromes,3. Duration and Frequency of prodromes vary widely.4. A definite statement about sidedness of headache in relation to prodrome could not be made.We feel a prospective study of prodromes is necessary to examine prodrome phenomena in greater detail.
Copper as a Factor in the Dietary Precipitation of Migraine
Authors: Harrison Dennis R 
Published: June 2005

SYNOPSISSubstances such as chocolate and glutamate are triggers of migraine. These and some other “migrainous substances” contain little or no tyramine. This suggests that other dietary factors are involved in the precipitation of migraine. These food substances play a role in the utilization of copper, which is known to be involved in the metabolism of vasoneuroactive amines such as serotonin, tyramine and the catecholamines.This paper suggests that it is the effects that these substances have on the copper pathway (i.e. its absorption and utilization) that is the primary consideration in the precipitation of migraine. Chocolate contains high levels of copper. Glutamate acts to bind and transport significant amounts of copper between blood and tissues. Citrate, found in “migrainous citrus fruits,” increases the intestinal absorption of copper; and both ascorbate and citrate may act to decrease oxidation of tyramine and serotonin, thereby raising the effective levels of these substances and perhaps triggering a migraine attack.A migraine episode would be made more likely upon the ingestion of these substances by susceptible individuals with abnormal copper metabolism such as lowered levels or altered ceruloplasmin, transferrin or albumin (known to bind copper), or a change in copper transport.
An Unusual Case of Migraine Accompaniments With Permanent Sequela ‐ A Case Report
Authors: Fisher C.M. 
Published: June 2005

SYNOPSISA woman aged 44 had recurrent migrainous scintillating scotomas without headache one or more times daily beginning before the age of 7. Spells were brought on by hunger, anger and regularly by straining to have a bowel movement. At age 44, while straining, she experienced a sharp pain in the head, a buzzing sound, virtual blindness and numbness of the left side. A left homonymous hemianopia persisted. During convalesence she experienced unusually vivid hallucinations in the hemianopic field and on phenytoin sodium therapy two sets of hallucinations ran at the same time. The head pain of this type of “catastrophic migraine” may be a third type of migraine pain.
Platelet Activation and Migraine: A Study with Flunarizine
Authors: D'Andrea Giovanni , Cananzi Antonio R. , Toldo Moreno , Ferro‐Milone Francesco 
Published: June 2005

SYNOPSISAlthough in common and classic migraine there is platelet activation both during painful attack and headache‐free periods, the role of platelets in migraine pathogenesis is not yet understood. Therefore, in order to investigate the relationship between platelets and migraine pathogenesis, β‐thromboglobulin (β‐TG) and platelet factor four (PF4), both platelet‐specific alpha granule proteins, were assayed in a group of patients with classic and complicated migraine before and after administration of an anti‐migraine drug, flunarizine, at a dose of 10 mg/daily. Blood samples for β‐TG and PF4 assay were collected for ten days in which the patients were headache‐free. β‐TG and PF4 plasma levels were elevated in all patients in comparison with control subjects. The patients with complicated migraine showed the highest plasma values. During flunarizine treatment β‐TG and PF4 levels persisted elevated in all patients, although a slight decrease of β‐TG plasma levels was observed. This data confirmed, as our previous works, that classic migraine is characterized by platelet activation “in vivo,” but that this may not be strictly related to migraine pathogenesis.
The Effect of Muscle Contraction Headache Chronicity on Frontal EMG
Authors: Callon Eleanor B. , Brantley Phillip J. , McAnulty David R , Waggoner Craig D. , Rappaport Neil B. , Goreczny Anthony J. , Jones Glenn N. 
Published: June 2005

SYNOPSISThe purpose of this study was to test the effect of muscle contraction headache chronicity on electromyographic (EMG) response.Frontal EMG was measured under two stress conditions and three baselines for subjects complaining of muscle contraction headaches for (1) 3 19 years, (2) £ 10 years, and (3) subjects not complaining of headaches of any kind. There were ten subjects in each group. The three groups were equivalent in age and sex distribution. They did not differ in their ratings of the stressfulness of the experimental conditions. Neither ANOVA nor ANCOVA with frequency of headache as the covariate supported Group differences or Group X Trials interactions. The results do not support the hypothesis that changes in frontal musculature occur as a function of the number of years that an individual has had a problem with muscle contraction headaches. The results are consistent with those of other EMG investigations employing an adaptation period of 3 5 minutes. They are also supportive of the recent skepticism about frontal EMG biofeedback as a critical component in the treatment of muscle contraction headaches.
Cephalic Hyperemia During Migraine Headaches. A Prospective Study
Authors: Meyer John Stirling , Zetusky Walter , Jonsdottir Maria , Mortel Karl 
Published: June 2005

SYNOPSISFor the past 6 years, patients with headaches followed and treated by this laboratory have undergone ateach visit serial measurements of regional cephalic blood flow (rCBF) with neurological and medicalexaminations, direct interviews and completion of questionnaires regarding type, frequency, presence andseverity of head pain. Of 369 patients referred with recurrent headaches, 324 were classified classic,common, or complicated migraine, either alone or in combination with muscle contraction headaches(mixed headaches) and 45 were considered to have pure muscle contraction headaches. For purposes ofthis report, patients with cluster headaches were excluded. Forty‐two percent (136) complained ofheadaches at the time or rCBF measurements. Of these 136, 60 cases had paired CBF measurementsduring headache and when headache‐free and comprise the case material analyzed. Most headaches (61%)occurred during the initial visit. During spontaneous migraine headaches, rCBF increases (hyperemia)were present among 58% of patients classified as classic migraine, 53% classified as common migraine,25% classified as complicated and 31% classified as mixed. Cephalic blood flow values were reducedduring prodromes of classic migraine. Patchy zones of oligemia and hyperemia appeared at the onset ofheadache. Cephalic hyperemia usually returned to normal values a few days after headaches subsided.During headache, 32% of the patients showed gross dysautoregulation with paradoxical flow increasesduring 100% oxygen inhalation. Results are consonant with a vascular pathogenesis for prodromes andheadaches of migraine.
Immunological Studies in Cluster Headache and Migraine
Authors: Visintini D. , Trabattoni G. , Manzoni G.C. , Lechi A. , Bortone L. , Behan P.O. 
Published: June 2005

SYNOPSISSerum complement component concentrations and immune complexes were studied in 47 patients withcluster headache, 32 with common migraine, 12 with classical migraine and two with possible milk‐allergicmigraine. No significant differences were found between the groups and two control populations: 63neurological patients without migraine and 30 normal healthy volunteers. The findings were similar both inand out of active periods of cluster headache and before and during migraine attacks. Bovine serumalbumin was detectable in the serum of the two cases postulated to have milk‐allergic migraine afteringestion of milk, but in neither case was an attack of migraine precipitated. Our results do not supportimplication of the complement system in either type of headache.
ATP Hyposecretion From Platelet Dense Bodies ‐‐ Evidence for the Purinergic Hypothesis and a Marker of Migraine
Authors: Joseph Rajiv , Welch K.M.A. , D'Andrea Giovanni , Levine Steven R. 
Published: June 2005

SYNOPSISWe tested the hypothesis that in migraineurs, there is hypofunction of the cerebral vasodilator purinergicsystem, which utilizes ATP and other adenine nucleotides as neurotransmitters. Besides being present inneuronal vesicles, ATP exists in a uniquely sequestered form in the dense bodies of platelets which are amodel for the study of neuronal vesicular function. Platelet ATP‐release and aggregation were measured inwhole blood by the newly developed impedance technique using collagen and epinephrine as inducingagents. Consistent with other reports, no responses were seen with epinephrine. With collagen induction,aggregation was nearly equal in controls and migraineurs. However, ATP‐release was significantly lowerin migraineurs with the higher collagen concentration. Stepwise logistic regression predicts that for each100 unit decrease in ATP‐release, the chances of being a migraineur increases by 1.89. We believe thatdecreased platelet ATP‐release is a marker of migraine reflecting hypofunction of the purinergic system,and as a result a relatively greater tendency for vasoconstriction which predisposes to migraine attacks.
Cardiovascular Reflex Responses During Migraine Attack
Authors: Havanka‐Kanniainen H 
Published: June 2005

SYNOPSISThe cardiovascular reflex responses of 10 migraine patients were recorded during both migraine attacks andheadache‐free intervals. Ten healthy subjects of similar age and sex served as a control group.When the results of the measurements for migraine patients performing an isometric work test duringmigraine attacks and during headache‐free intervals were compared, during migraine attacks a statisticallysignificant smaller increase in diastolic B.P. was encountered than interictally (p<0.05).When the results for migraine patients during migraine attack, and controls, were compared, statisticallysignificant differences were encountered in the pulse rate variation in Valsalva manoeuvre, in an orthostatictest, and in the systolic and diastolic blood pressure reactions in an isometric work test. The mean Valsalvaratio and R‐R‐interval ratio during the orthostatic test were lower in migraine patients during migraine attackthan in controls, and the mean blood pressure rise in the isometric work test was also lower in the migrainepatients group during attacks.There were no statistically significant differences between the results of the migraine patients duringheadache‐free intervals and those of the control subjects.
Differential Effects of Training in Relaxation and Stress‐Coping in Patients with Migraine
Authors: Sorbi Marjolijn , Tellegen Bert 
Published: June 2005

SYNOPSISThe effects of a psychophysiological treatment (relaxation training) and a psychological treatment(stress‐coping training) were tested in 29 patients suffering from migraine.There were significant pre‐post reductions in migraine variables and drug consumption. The effects didnot differ between the types of training, and remained stable for a medium‐term follow‐up of 8 months. Wethink, however, that stress‐coping training may in course of time be superior in maintaining training gains.Although this assumption cannot yet be tested for longer follow‐up periods, there was a non‐significanttrend for stress‐coping training to be more effective in migraine 8 months after training.There were different effects on social behavior: patients receiving relaxation training became moresocially withdrawn, while patients who underwent stress‐coping training increased their socialassertiveness. Furthermore, according to the participants, relaxation training had a stronger impact onmigraine, whereas stress‐coping training was more directed at migraine‐related stress. However, pre‐postcomparisons of the patients' coping with stress for the most part did not reveal significantly differenteffects between the two types of training.