bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of abdominal metastatic dermatofibrosarcoma protuberans misdiagnosed as gastrointestinal stromal tumor
Authors: Deng Minying , Liu Qingxiao , Ren Lei , Yuan Wei , Xu Chen , Hou Yingyong 
Published: February 2024

AbstractDermatofibrosarcoma protuberans (DFSP) is a low-grade malignant soft-tissue tumor that originates from the skin. It has a slow onset in the early stages, non-specific clinical symptoms, low specificity, and can easily be overlooked, missed, or misdiagnosed by clinicians and pathologists. In addition, DFSP is prone to recurrence after local surgical treatment; however, distant metastasis, especially abdominal metastasis, is rare, which is also a challenge for the accurate diagnosis of DFSP when it progresses distantly. Now a case of abdominal metastasis of DFSP is reported. The patient has been treated with imatinib for ten years, and the lesion has shrunk, but because the patient has been receiving imatinib treatment, his abdominal lesion was once misdiagnosed as gastrointestinal stromal tumor. Therefore, we report on this case to enhance the understanding of the diagnosis and treatment of DFSP, and to provide reference for the pathological diagnosis and precise treatment of such patients.
Structured 3′ UTRs destabilize mRNAs in plants
Authors: Zhang Tianru , Li Changhao , Zhu Jiaying , Li Yanjun , Wang Zhiye , Tong Chun-Yip , Xi Yu , Han Yi , Koiwa Hisashi , Peng Xu , Zhang Xiuren 
Published: February 2024

Abstract
Background
RNA secondary structure (RSS) can influence the regulation of transcription, RNA processing, and protein synthesis, among other processes. 3′ untranslated regions (3′ UTRs) of mRNA also hold the key for many aspects of gene regulation. However, there are often contradictory results regarding the roles of RSS in 3′ UTRs in gene expression in different organisms and/or contexts.

Results
Here, we incidentally observe that the primary substrate of miR159a (pri-miR159a), when embedded in a 3′ UTR, could promote mRNA accumulation. The enhanced expression is attributed to the earlier polyadenylation of the transcript within the hybrid pri-miR159a-3′ UTR and, resultantly, a poorly structured 3′ UTR. RNA decay assays indicate that poorly structured 3′ UTRs could promote mRNA stability, whereas highly structured 3′ UTRs destabilize mRNA in vivo. Genome-wide DMS-MaPseq also reveals the prevailing inverse relationship between 3′ UTRs’ RSS and transcript accumulation in the transcriptomes of Arabidopsis, rice, and even human. Mechanistically, transcripts with highly structured 3′ UTRs are preferentially degraded by 3′–5′ exoribonuclease SOV and 5′–3′ exoribonuclease XRN4, leading to decreased expression in Arabidopsis. Finally, we engineer different structured 3′ UTRs to an endogenous FT gene and alter the FT-regulated flowering time in Arabidopsis.

Conclusions
We conclude that highly structured 3′ UTRs typically cause reduced accumulation of the harbored transcripts in Arabidopsis. This pattern extends to rice and even mammals. Furthermore, our study provides a new strategy of engineering the 3′ UTRs’ RSS to modify plant traits in agricultural production and mRNA stability in biotechnology.
Statistical analysis plan for the phaco TIp position during clear corneal Phacoemulsification Surgery (TIPS) randomized controlled trial
Authors: Kaup Soujanya , Kondal Dimple , Shivalli Siddharudha , Buchan John 
Published: February 2024

Abstract
Background
Cornea is the most important refractive media in the eye, and damage to the corneal endothelium is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with predisposing factors. The role of phaco tip position during phacoemulsification on corneal endothelial damage is ambiguous, and there is no consensus regarding the most cornea-friendly phaco tip position (bevel-up or bevel-down). The objective of the trial is to compare the effect of phaco tip position (bevel-up vs. bevel-down) during phacoemulsification using direct chop technique on corneal endothelial cell count.

Methods and design
TIPS is a randomised, multicentre, parallel-group, triple-masked (participant, outcome assessor, and statistician) trial with 1:1 allocation ratio. A total of 480 eligible participants, aged > 18 years with immature cataract, will be randomly allocated into bevel-up and bevel-down groups at two centres. Randomisation will be stratified according to the cataract grade. The primary outcome is postoperative endothelial cell count at 1 month. Secondary outcomes are central corneal thickness on postoperative days 1, 15, and 30 and difference in intraoperative complications.

Conclusion
In this paper, we describe the detailed statistical analysis plan (SAP) for the TIPS trial, which was prepared prior to database lock. The SAP includes details of planned analyses and unpopulated tables, which will be reported in the publications. We plan to lock the database in July 2023 and publish the results later in the same year.
SAP Version 0.1 (dated: 28 April 2023)
Protocol version:2.0

Trial registration
Clinical Trial Registry of India CTRI/2019/02/017464. Registered on 5 February 2019; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=29764&EncHid=&userName=2019/02/017464
Prediction modeling of cigarette ventilation rate based on genetic algorithm backpropagation (GABP) neural network
Authors: Wei Jiaxin , Wang Zhengwei , Li Shufang , Wang Xiaoming , Xu Huan , Wang Xiushan , Yao Sen , Song Weimin , Wang Youwei , Mei Chao 
Published: February 2024

AbstractThe ventilation rate of cigarettes is an important indicator that affects the internal quality of cigarettes. When producing cigarettes, the unit may experience unstable ventilation rates, which can lead to a decrease in cigarette quality and pose certain risks to smokers. By establishing the ventilation rate prediction model, guide the design of unit parameters in advance, to achieve the goal of stabilizing unit ventilation rate, improve the stability of cigarette ventilation rate, and enhance the quality of cigarettes. This paper used multiple linear regression networks (MLR), backpropagation neural networks (BPNN), and genetic algorithm-optimized backpropagation (GABP) to construct a model for the prediction of cigarette ventilation rate. The model results indicated that the total ventilation rate was significantly positively correlated with weight (P < 0.01), circumference, hardness, filter air permeability, and open resistance. The results showed that the MLR models' (RMSE = 0.652, R2 = 0.841) and the BPNN models’ (RMSE = 0.640, R2 = 0.847) prediction ability were limited. Optimization by genetic algorithm, GABP models were generated and exhibited a little better prediction performance (RMSE = 0.606, R2 = 0.873). The results indicated that the GABP model has the highest accuracy in the prediction of predicting ventilation rate and can accurately predict cigarette ventilation rate. This method can provide theoretical guidance and technical support for the stability study of the ventilation rate of the unit, improve the design and manufacturing capabilities and product quality of short cigarette products, and help to improve the quality of cigarettes.
“For and against” factors influencing participation in personalized breast cancer screening programs: a qualitative systematic review until March 2022
Authors: Laza Celmira , Niño de Guzmán Ena , Gea Montserrat , Plazas Merideidy , Posso Margarita , Rué Montserrat , Castells Xavier , Román Marta 
Published: February 2024

Abstract
Background
Personalized breast cancer screening is a novel strategy that estimates individual risk based on age, breast density, family history of breast cancer, personal history of benign breast lesions, and polygenic risk. Its goal is to propose personalized early detection recommendations for women in the target population based on their individual risk. Our aim was to synthesize the factors that influence women’s decision to participate in personalized breast cancer screening, from the perspective of women and health care professionals.

Methods
Systematic review of qualitative evidence on factors influencing participation in personalized Breast Cancer Screening. We searched in Medline, Web of science, Scopus, EMBASE, CINAHL and PsycINFO for qualitative and mixed methods studies published up to March 2022. Two reviewers conducted study selection and extracted main findings. We applied the best-fit framework synthesis and adopted the Multilevel influences on the cancer care continuum model for analysis. After organizing initial codes into the seven levels of the selected model, we followed thematic analysis and developed descriptive and analytical themes. We assessed the methodological quality with the Critical Appraisal Skills Program tool.

Results
We identified 18 studies published between 2017 and 2022, conducted in developed countries. Nine studies were focused on women (n = 478) and in four studies women had participated in a personalized screening program. Nine studies focused in health care professionals (n = 162) and were conducted in primary care and breast cancer screening program settings. Factors influencing women’s decision to participate relate to the women themselves, the type of program (personalized breast cancer screening) and perspective of health care professionals. Factors that determined women participation included persistent beliefs and insufficient knowledge about breast cancer and personalized screening, variable psychological reactions, and negative attitudes towards breast cancer risk estimates. Other factors against participation were insufficient health care professionals knowledge on genetics related to breast cancer and personalized screening process. The factors that were favourable included the women’s perceived benefits for themselves and the positive impact on health systems.

Conclusion
We identified the main factors influencing women’s decisions to participate in personalized breast cancer screening. Factors related to women, were the most relevant negative factors. A future implementation requires improving health literacy for women and health care professionals, as well as raising awareness of the strategy in society.
[89Zr]Zr-PSMA-617 PET/CT characterization of indeterminate [68Ga]Ga-PSMA-11 PET/CT findings in patients with biochemical recurrence of prostate cancer: lesion-based analysis
Authors: Rosar Florian , Burgard Caroline , Larsen Elena , Khreish Fadi , Marlowe Robert J. , Schaefer-Schuler Andrea , Maus Stephan , Petto Sven , Bartholomä Mark , Ezziddin Samer 
Published: February 2024

Abstract
Background
The state-of-the-art method for imaging men with biochemical recurrence of prostate cancer (BCR) is prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) with tracers containing short-lived radionuclides, e.g., gallium-68 (68Ga; half-life: ∼67.7 min). However, such imaging not infrequently yields indeterminate findings, which remain challenging to characterize. PSMA-targeted tracers labeled with zirconium-89 (89Zr; half-life: ∼78.41 h) permit later scanning, which may help in classifying the level of suspiciousness for prostate cancer of lesions previously indeterminate on conventional PSMA-targeted PET/CT.

Methods
To assess the ability of [89Zr]Zr-PSMA-617 PET/CT to characterize such lesions, we retrospectively analyzed altogether 20 lesions that were indeterminate on prior [68Ga]Ga-PSMA-11 PET/CT, in 15 men with BCR (median prostate-specific antigen: 0.70 ng/mL). The primary endpoint was the lesions’ classifications, and secondary endpoints included [89Zr]Zr-PSMA-617 uptake (maximum standardized uptake value [SUVmax]), and lesion-to-background ratio (tumor-to-liver ratio of the SUVmax [TLR]). [89Zr]Zr-PSMA-617 scans were performed 1 h, 24 h, and 48 h post-injection of 123 ± 19 MBq of radiotracer, 35 ± 35 d post-[68Ga]Ga-PSMA-11 PET/CT.

Results
Altogether, 6/20 previously-indeterminate lesions (30%) were classified as suspicious (positive) for prostate cancer, 14/20 (70%), as non-suspicious (negative). In these two categories, [89Zr]Zr-PSMA-617 uptake and lesional contrast showed distinctly different patterns. In positive lesions, SUVmax and TLR markedly rose from 1 to 48 h, with SUVmax essentially plateauing at high levels, and TLR further steeply increasing, from 24 to 48 h. In negative lesions, uptake, when present, was very low, and decreasing, while contrast was minimal, from 1 to 48 h. No adverse events or clinically-relevant vital signs changes related to [89Zr]Zr-PSMA-617 PET/CT were noted during or ~ 4 weeks after the procedure.

Conclusions
In men with BCR, [89Zr]Zr-PSMA-617 PET/CT may help characterize as suspicious or non-suspicious for prostate cancer lesions that were previously indeterminate on [68Ga]Ga-PSMA-11 PET/CT.

Trial registration
Not applicable.
The volatility mechanism and intelligent fusion forecast of new energy stock prices
Authors: Fan Guo-Feng , Zhang Ruo-Tong , Cao Cen-Cen , Peng Li-Ling , Yeh Yi-Hsuan , Hong Wei-Chiang 
Published: February 2024

AbstractThe new energy industry is strongly supported by the state, and accurate forecasting of stock price can lead to better understanding of its development. However, factors such as cost and ease of use of new energy, as well as economic situation and policy environment, have led to continuous changes in its stock price and increased stock price volatility. By calculating the Lyapunov index and observing the Poincaré surface of the section, we find that the sample of the China Securities Index Green Power 50 Index has chaotic characteristics, and the data indicate strong volatility and uncertainty. This study proposes a new method of stock price index prediction, namely, EWT-S-ALOSVR. Empirical wavelet decomposition extracts features from multiple factors affecting stock prices to form multiple sub-columns with features, significantly reducing the complexity of the stock price series. Support vector regression is well suited for dealing with nonlinear stock price series, and the support vector machine model parameters are selected using random wandering and picking elites via Ant Lion Optimization, making stock price prediction more accurate.
Characteristics of patients with non-cancer pain and long-term prescription opioid use who have used medical versus recreational marijuana
Authors: Davidson Whitney M. , Mahavni Anika , Chrusciel Timothy , Salas Joanne , Miller-Matero Lisa R. , Sullivan Mark D. , Zabel Celeste , Lustman Patrick J. , Ahmedani Brian K. , Scherrer Jeffrey F. 
Published: February 2024

Abstract
Objective
Marijuana use is increasingly common among patients with chronic non-cancer pain (CNCP) and long-term opioid therapy (LTOT). We determined if lifetime recreational and medical marijuana use were associated with more frequent and higher dose prescription opioid use.

Design
Cross-sectional

Subjects
Eligible patients (n=1,037), who had a new period of prescription opioid use lasting 30-90 days, were recruited from two midwestern health care systems to a study of long-term prescription opioid use and mental health outcomes. The present cross-sectional analyses uses baseline data from this on-going cohort study.

Methods
Primary exposures were participant reported lifetime recreational and medical marijuana use versus no lifetime marijuana use. Prescription opioid characteristics included daily versus non-daily opioid use and ≥50 morphine milligram equivalent (MME) dose per day vs. <50 MME. Multivariate, logistic regression models estimated the association between lifetime recreational and medical marijuana use vs. no use and odds of daily and higher dose prescription opioid use, before and after adjusting for confounding.

Results
The sample was an average of 54.9 (SD±11.3) years of age, 57.3% identified as female gender, 75.2% identified as White, and 22.5% identified as Black race. Among all participants, 44.4% were never marijuana users, 21.3% were recreational only, 7.7% medical only and 26.6% were both recreational and medical marijuana users. After controlling for all confounders, lifetime recreational marijuana use, as compared to no use, was significantly associated with increased odds of daily prescription opioid use (OR=1.61; 95%CI:1.02-2.54). There was no association between lifetime recreational or medical marijuana use and daily opioid dose.

Conclusion
Lifetime medical marijuana use is not linked to current opioid dose, but lifetime recreational use is associated with more than a 60% odds of being a daily prescription opioid user. Screening for lifetime recreational marijuana use may identify patients with chronic pain who are vulnerable to daily opioid use which increases risk for adverse opioid outcomes. Prospective data is needed to determine how marijuana use influences the course of LTOT and vice versa.
Fenfluramine for the treatment of status epilepticus: use in an adult with Lennox–Gastaut syndrome and literature review
Authors: Strzelczyk Adam , Becker Hendrik , Tako Lisa , Hock Susanna , Hattingen Elke , Rosenow Felix , Mann Catrin 
Published: February 2024

Abstract
Background
Novel treatments are needed to control refractory status epilepticus (SE). This study aimed to assess the potential effectiveness of fenfluramine (FFA) as an acute treatment option for SE. We present a summary of clinical cases where oral FFA was used in SE.

Methods
A case of an adult patient with Lennox–Gastaut syndrome (LGS) who was treated with FFA due to refractory SE is presented in detail. To identify studies that evaluated the use of FFA in SE, we performed a systematic literature search.

Results
Four case reports on the acute treatment with FFA of SE in children and adults with Dravet syndrome (DS) and LGS were available. We report in detail a 30-year-old woman with LGS of structural etiology, who presented with generalized tonic and dialeptic seizures manifesting at high frequencies without a return to clinical baseline constituting the diagnosis of SE. Treatment with anti-seizure medications up to lacosamide 600 mg/d, brivaracetam 300 mg/d, valproate 1,600 mg/d, and various benzodiazepines did not resolve the SE. Due to ongoing refractory SE and following an unremarkable echocardiography, treatment was initiated with FFA, with an initial dose of 10 mg/d (0.22 mg/kg body weight [bw]) and fast up-titration to 26 mg/d (0.58 mg/kg bw) within 10 days. Subsequently, the patient experienced a resolution of SE within 4 days, accompanied by a notable improvement in clinical presentation and regaining her mobility, walking with the assistance of physiotherapists. In the three cases reported in the literature, DS patients with SE were treated with FFA, and a cessation of SE was observed within a few days. No treatment-emergent adverse events were observed during FFA treatment in any of the four cases.

Conclusions
Based on the reported cases, FFA might be a promising option for the acute treatment of SE in patients with DS and LGS. Observational data show a decreased SE frequency while on FFA, suggesting a potentially preventive role of FFA in these populations.

Key points

We summarize four cases of refractory status epilepticus (SE) successfully treated with fenfluramine.

Refractory SE resolved after 4–7 days on fenfluramine.

Swift fenfluramine up-titration was well-tolerated during SE treatment.

Treatment-emergent adverse events on fenfluramine were not observed.

Fenfluramine might be a valuable acute treatment option for SE in Dravet and Lennox–Gastaut syndromes.
Successful surgical intervention for acute pyothorax caused by methicillin-resistant Staphylococcus aureus thoracic pyogenic spondylitis: a case report
Authors: Kitamura Naoya , Shimada Yoshifumi , Futakawa Hayato , Makino Hiroto , Takegoshi Yusuke , Kawasuji Hitoshi , Tanabe Keitaro , Ojima Toshihiro , Shimoyama Koichiro , Yamamoto Yoshihiro , Kawaguchi Yoshiharu , Tsuchiya Tomoshi 
Published: February 2024

Abstract
Background
Pyogenic spondylitis or intervertebral discitis rarely spreads into the thoracic cavity, resulting in pyothorax. Moreover, no study has reported methicillin-resistant Staphylococcus aureus (MRSA) as a cause. Conservative and surgical treatments are reportedly effective for the above-mentioned situations; however, there have been no comprehensive reports owing to the disease’s rarity. This report described a case of acute pyothorax due to MRSA-caused pyogenic spondylitis in which surgical intervention with curettage of the intrapleural abscess and simultaneous thoracic vertebral debridement and anterior fixation were effective.

Case presentation
A 60-year-old female with Parkinson’s disease was diagnosed with pyogenic spondylitis caused by MRSA and managed with antibiotics. Subsequently, a right encapsulated pleural effusion was observed, and thoracentesis was performed. No bacteria were identified in the pleural fluid culture; nonetheless, the leukocytes in the fluid increased, and the patient was diagnosed with right acute pyothorax caused by pyogenic spondylitis. Management of the spondylitis and pyothorax before the disease became severe was necessary.
We performed curettage of the intrapleural abscess and vertebral debridement and anterior fixation using an autogenous rib through open thoracotomy. The inflammation or accompanying symptoms did not worsen 3 months after hospital discharge.

Conclusions
Acute pyothorax is rare but may develop from pyogenic spondylitis, for which MRSA is a rarer causative agent. Simultaneous vertebral debridement and anterior fixation, with curettage of the thoracic cavity abscess, may be useful in its management.
frequency of coffee consumption in the Slavic population and its impact on health
Authors: Czchowski Konrad , Kościołek Aleksandra , Misiak Jakub , Kościołek Dawid , Kępczyk Martyna , Ojdana Miłosz , Urbaś Michał , Surowiecka Kaja , Szalbot Konrad , Tokarski Mikołaj 
Published: February 2024

Introduction and purpose:
There are many articles specifying coffee's influence on the health and behavior of consumers. However, most of the studies are conducted on populations living in the United States, Western Europe or China. We did not find many studies reporting the effects of coffee consumption on the Slavic population. The aim of our study was to determine the frequency of coffee consumption in this population and its impact on such health elements as insomnia, body weight, well-being, irritation, hypertension or headache.
Material and method:
The anonymous survey included questions about the frequency of coffee consumption and selected health effects was created and subsequently distributed through social media (Telegram platform) in August 2023.
Results:
We collected a total of 89 surveys. The median age of participants was 31 (IQR: 24-38). 27 individuals indicated that they do not consume coffee at all (30.34%). The rest of the group most often choose the following options: I drink it several times a day - 24 individuals (26.97%) and 26 individuals drink it once a day (29.21%). We demonstrated a correlation between the amount of coffee consumption and the frequency of insomnia (r=0.39, p=0.028). Additionally, we observed a negative correlation between coffee consumption and body weight (r=0.18, p=0.048). However, we did not find a relationship between coffee consumption and elevated or lowered mood (p>0.05).
Conclusions:
In the study group, the frequency of coffee consumption was higher than the global average and in some cases led to insomnia. The positive aspects of drinking coffee outweighed the side effects and lead to the conclusion that it is a safe drink in the group of surveyed Slavs.