bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Enriched Culture Media for Culturing Streptococcus pyogenes by using Spirulina Powder
Authors: Abdelazim Ahmed Mohammed , Mohammed Abdelrahman Eldaw , Arabi Omer Hassan 
Published: February 2024

Background and Aim: Fastidious bacteria require special nutrients and growth factors to grow on enriched culture media. Many enriched culture media were developed for culturing and isolating fastidious bacteria in pure cultures. The present study investigates the ability of spirulina powder to support the fastidious bacteria growth in pure culture compared to ordinary enriched media, e.g., Blood agar and Chocolate agar.
Methods: Spirulina powder was used as a nutrient source with some additives to prepare different types of Spirulina media. Reference strain ATCC (19615) and three clinical isolates of Streptococcus pyogenes were examined for their growth on the developed candidate medium. Three formulations of spirulina powder were used: Medium 1, Medium 2, and Medium 3.
Results: All spirulina media supported the growth of streptococcus pyogenes and there was no significant difference in the morphology and cultural characteristics on the blood agar and chocolate agar media. Colonies size of streptococcus pyogenes were slightly smaller size on spirulina media.
Conclusion: Spirulina media is a possible candidate that can be used as enriched culture media for culturing and isolating fastidious bacteria such as Streptococcus pyogenes.
Keyword: Spirulina powder, enriched culture media, Streptococcus pyogenes.
Optimization of extraction and lyophilization conditions of Feretia apodanthera (Rubiaceae) leaf powders for galenic formulation
Authors: Ouédraogo Salfo , TRAORE Tata Kadiatou , Ishola Taofick , Ouédraogo Benjamin , Boly Abdoul Laurent Gilchrist , Silué Gniènèfèrètien Nounaféri Awa , Ngolsou Françis , Semdé Rasmané 
Published: February 2024

Feretia apodanthera (Rubiaceae) is used in traditional medicine for the treatment of various pathologies. Its leaves are chewed and swallowed to treat stomach aches, sleep disorders, etc. With the aim of improving the extraction method in order to obtain high contents of phytochemical compounds and good antioxidant activity, this study aimed to highlight the extraction and lyophilization conditions of two extracts (aqueous and hydro-ethanolic) leaves of Feretia apodanthera.
An aqueous and hydro-ethanolic extraction was carried out from the leaf powder of Feretia apodanthera, after a maceration plan (mass/volume ratio and extraction time). The extracts obtained were freeze-dried (flask size, filling volume and freeze-drying time) in order to determine the optimal extraction conditions. A phytochemical screening of the extracts with extreme yields of different solvents was carried out by TLC, which led to the determination of certains compounds of interest and the evaluation of the antioxidant activity by the DPPH and FRAP method.
The optimal maceration conditions were 02 hours and m/V ratio of 1/20 for the aqueous extract and those of the ethanolic extract were 30 min and m/V ratio of 1/20. The optimal freeze-drying conditions were 60h and a 500ml flask 1/3 filled. The presence of flavonoids, tannins, saponosides, coumarins, triterpenes and sterols has been highlighted. The phenolics compounds contents of hydro-ethanolic lyophilisates were higher than those of aqueous lyophilisates. There was no statistical difference between the antioxidant activity of the different extracts.
The optimal conditions will serve as a standard for the production of the extract necessary for the formulation.
Keywords : Feretia apodanthera, extraction, freeze-drying, phenolics compounds, antioxidant.
Evaluation of Therapeutic Response Under Biologic Therapy in Patients with Rheumatoid Arthritis
Authors: Djebbar Badia , BOUDJELLA Mohamed Lotfi 
Published: February 2024

Biotherapy has revolutionized the therapeutic management of rheumatoid arthritis (RA). The objective of the study was to evaluate and compare the efficacy and tolerance of biological disease modifying antirheumatic drugs (bDMARDs) and conventional disease modifying antirheumatic drugs ( cDMARDs) used in RA.
It was a retrospective study covering 13 years at the level of the immunology unit of the UHU Hassiba Ben Bouali Blida and functional rehabilitation service of the CHU Frantz Fanon Blida. We identified 1866 records of patients with RA, 75 receiving biotherapy and 71 receiving conventional treatment. The therapeutic response was evaluated by the DAS 28-ESR (disease activity score based on erythrocyte sedimentation rate) and interpreted according to the EULAR (European league against rheumatism) judgements criteria.
A female predominance of 83%, the average age of RA patients was 49.3 ±13.42 years, the mean starting DAS28-ESR was 5.625± 1.4. 84% of patients initially received MTX (methotrexate) on the front line, the decrease in DAS28-ESR was non- significant, with patients exhibiting intolerance (41%), and (45%) ineffectiveness. The introduction of biotherapy mainly Actemra allowed a decrease of DAS28-ESR of - 1.842±0.3812, a significant decrease according to the criteria of the EULAR. Humira had an adverse efficacy and tolerance profile (including the occurrence of severe adverse effects (AEs)).
In conclusion, biotherapy is more effective than conventional treatments, while in terms of tolerance data are insufficient to make a judgment on it.
Keywords: Rheumatoid arthritis – Biotherapy.
Formulating and evaluating a gel that contains Eletriptan-loaded transferosomes
Authors: Begum Mobina , Rawoof Abdul , Jasmine D , Fatima Sana 
Published: February 2024

Transdermal-vesicular drug delivery systems offer various advantages over conventional drug delivery systems, such as bypassing first-pass metabolism, site-specific delivery, reduced dosing frequency, and more. The objective of the present research involves the formulation and in-vitro evaluation of Eletriptan transferosomal gel to reduce dosing frequency. Transferosomes act as vehicles for on-site drug delivery, and they are vesicular systems with a flexible membrane. By formulating this type, we can achieve a higher concentration at the site of action, thereby reducing dosing frequency.
Fourier-transform infrared spectra revealed that there was no interaction between the drug and excipients. Transferosomal formulations were prepared by the thin-film hydration technique and were incorporated into 1.5% Carbopol gel. From the results, Formulation code-ET6, containing Lecithin: Tween-80, has higher entrapment efficiency and maximum drug release, and is hence considered the optimized formulation. Stability studies performed for optimized transferosomal gel formulations indicate that the prepared transferosomal gel has more stability at a lower temperature.
The conclusion is that, based on the above data, it is confirmed that the prepared Eletriptan transferosomal gels can be considered as one of the promising approaches to reducing dosing frequency and maintaining drug concentration at the desired site for a longer time.
Keywords: Transdermal drug delivery, Eletriptan, Transferosomes, Thin Film Hydration Method, Carbopol gel.
Effectiveness of Botulinum Toxin for Oncologic Pain
Authors: Hernández-Rodríguez Daniela , Guillén-Núñez María del Rocío , Juárez-Lemus Angel Manuel , Plancarte-Sánchez Ricardo , Aguilera-Elizalde Blanca Betsabé , González-Vega Oliver Humberto 
Published: February 2024

Introduction: The use of botulinum toxin for medical purposes has expanded nowadays through the extensive study of its complex structure and mechanism of action, highlighting its ability to inhibit the release of acetylcholine, and its impact on the chemical signaling cascade involved in different models of pain.
Objective: To evaluate the association of the use of botulinum toxin A with the reduction of pain in oncologic patients at Instituto Nacional de Cancerología, México.
Methodology: A retrospective, observational, descriptive, and cross-sectional study was performed. Data were obtained from patients attended during the period from January 1, 2022 to September 30, 2023 in whom botulinum toxin was applied as an adjuvant for pain management.
Results: Thirty-two patients who met the inclusion criteria were included. After the application of botulinum toxin there was a statistically significant reduction in pain, as measured by the Numeric Pain Rating Scale and Verbal Rating Scale. The degree of satisfaction after the application of botulinum toxin was measured by a Likert-type scale, and 68% satisfaction was found in the patients who underwent the onotoxin treatment.
Conclusions: The use of botulinum toxin proved to be an effective and safe therapy, complementary to the multimodal approach for the treatment of different pain patterns in oncologic patients. It can be considered as a pharmacological option for use in this group of patients.
Keywords: Oncologic pain, Pain management, Botulinum toxin
Histochemical Investigation of Exotic Weed Lantana camara Linn
Authors: Adsare A. M. , Khalkar K. M. , Gaikwad Saurav Somnath 
Published: February 2024

The histochemical Studies of leaves, Root and Stem of Lantena camara Linn.(Verbenaceae) in Maharashtra. It is a annual shrub grown widely in different places of India. The species has been investigated for the phytochemical, anti-oxidant and antimicrobial Potential. This paper encompasses a comprehensive review on histochemical and Biological aspects of Lantena camara L. For histochemical studies the freehand sections of leaves, stem and root were taken and treated with respective reagent in localize component, viz. Starch, protein, tannin, saponin, fat, and alkaloids in the tissues.
Keywords: Histochemistry, Lantena, Alkaloids, Protein
Inspira 1 2020
Authors: Leonardsen Ann-Chatrin Linqvist 
Published: February 2024

Dette er en fulltekst av tidsskriftet Inspira nummer 1, 2020. Merk at tidsskriftet publiseres av Cappelen Damm Akademisk fra og med 15. januar 2021.
Innhold:
Redaktøren uttaler seg: Ann-Chatrin Leonardsen
Observasjonsskjema for måling av ISBAR: Linda Skaug Tangvik, Mats A. Kinn-Mikalsen,Tone Johnsgaard, Marit Hegg Reime
Effekt av sedasjonsprotokoll til respiratorpasientar – ei systematisk oversikt og metaanalyse: Leni Jektvik Haugland, Marit Hegg Reime, Pål Andre Hegland
Bruk av dagbok hos intensivpasienter: Sophie Baastad, Vivian Nystrøm, Ann-Chatrin Leonardsen
STØY øker sederingsbehov: Vivian Nystrøm, Idunn Brekke
Approaches to building communication and interaction with modern children in the context of ensuring their psychological safety
Authors: Пазухина Светлана Вячеславовна 
Published: February 2024

Актуальность исследования состоит в выявлении новых вызовов и угроз, связанных с проблемой организации педагогического общения и учебного взаимодействия с детьми поколения Z. Новизна заключается в том, что проблема обеспечения психологической безопасности личности в образовательной среде рассматривается с позиции двух подходов: возрастно-психологического и информационно-педагогического. Первый из них связан с учетом особенностей поколения Z при выстраивании общения и учебного взаимодействия с ними, второй предполагает спецификацию использования цифровых технологий в образовательной среде с учетом рисков и угроз, которые могут возникать при их применении. Традиционные общепсихологические закономерности обучения, развития, воспитания школьников пересматриваются в контексте необходимости учета особенностей цифрового поколения и современных условий реализации образовательного процесса. Подчеркивается значимость повышения авторитета учителя, развития у него востребованных педагогических способностей, формирования ценностных отношений к детям, профессии, себе как постоянно развивающейся личности и профессионалу. Выявленные риски и угрозы составляют особый пласт воспитательной работы современного учителя в контексте обеспечения психологической безопасности обучающихся как в учебном процессе, так и за его пределами.
The relevance lies in identifying new challenges and threats related to the problem of organizing pedagogical communication and educational interaction with children of generation Z. The novelty lies in the fact that the problem of ensuring the psychological security of the individual in the educational environment is viewed from the perspective of two approaches: age-psychological and information-pedagogical. The first of them is associated with taking into account the peculiarities of the Z-generation when building communication and educational interaction with them, the second involves the specification of the use of digital technologies in the educational environment, taking into account the risks and threats that may arise when using them. The traditional general psychological patterns of teaching, development, and education of schoolchildren are being revised in the context of the need to take into account the features of the digital generation and modern conditions for the implementation of the educational process. The importance of increasing the authority of the teacher, the development of his demanded pedagogical abilities, the formation of value relations to children, profession, himself as a constantly developing personality and professional is emphasized. The identified risks and threats constitute a special layer of the educational work of a modern teacher in the context of ensuring the psychological safety of students both in the educational process and beyond.
To the problem of meaning formation in the professional training of students – future envi-ronmental designers
Authors: Колесник Надежда Борисовна 
Published: February 2024

Рассматривается проблема качества профессиональной подготовки средовых дизайнеров, выраженная в отсутствии у студентов личностно-смыслового включения в профессиональную деятельность. Анализируются причины, оказывающие влияние на уровень смыслообразования и целеполагания в процессе обучения средовому дизайну в высшей школе. Охарактеризованы пути осмысления и формирования профессиональной идентичности. Установлено, что усилению смысловой компоненты в системе профессиональной подготовки средовых дизайнеров в вузе способствует моделирование образа самого себя в будущей профессии в контексте личностных характеристик, имеющегося опыта у студентов и перспективного видения. Выявлены механизмы профессионального смыслообразования, приводящие в действие сущностные силы человека на формирование личностных качеств, социальной активности и способности к самостоятельному целеполаганию и готовности к самореализации в сфере дизайна. Определены положения методики обучения средовому дизайну, эффективно формирующие у студентов мотивационные установки в получении профессии и саморазвитии своих профессиональных умений и навыков. Описаны условия личностно ориентированного обучения студентов – будущих средовых дизайнеров с учетом смыслообразования.
The problem of the quality of professional training of environmental designers is considered, expressed in the absence of students of personal and semantic inclusion in professional activity. The reasons affecting the level of meaning and goal setting in the process of teaching environmental design in higher education are analyzed. Ways of understanding and formation of professional identity are characterized. It has been established that the strengthening of the semantic component in the system of professional training of environmental designers at the university is facilitated by the semantic modeling of the image of oneself in the future profession in the context of personal characteristics and existing experience. Mechanisms of professional self-determination have been identified, involving semantic modeling of the image of oneself in the future profession, which actuates the essential forces of a person on the formation of personal qualities, social activity and the ability to independently target and readiness for self-realization in the field of design. The provisions of the methodology for teaching environmental design have been determined, effectively forming motivational attitudes among students in obtaining a profession and developing their professional skills and skills. The conditions for the personal-oriented training of students - future environmental designers, taking into account the formation of meaning, are described.
Pengaruh Layanan Informasi Menggunakan Teknik Sosiodrama terhadap Peran Sosial Peserta Didik SMA Muhammadiyah 1 Metro
Authors: Wibowo Agus , Muzni Achmad Irfan , Handiliana Baqista 
Published: February 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh layanan informasi menggunakan teknik sosiodrama terhadap peran sosial peserta didik SMA Muhammadiyah 1 Metro Tahun Pelajaran 2019/2020.Penelitian ini menggunakan desain kuantitatif eksperimen dengan One Group Pretest-Posttest Design. Populasi penelitian sebanyak 159 dengan total peran sosial rendah sebanyak 19 peserta didik. Sampel penelitian berjumlah 19 peserta didik total dari populasi. Instrumen dalam pengambilan data menggunakan metode kuesioner model skala likert. Analisis data yang digunakan yaitu uji t. Hasil perhitungan data adalah diperoleh thitung= 59983 > 1,729 dari signifikasi 0,05, selain itu diketahui bahwa terjadi peningkatan skor pre-test sebesar 88,9 dan post-test sebesar 115,8 sehingga terjadi kenaikan skor sebanyak 22,2. Hal itu menunjukkan bahwa layanan informasi menggunakan teknik sosiodrama berpengaruh terhadap peran sosial peserta didik.Kesimpulan pada penelitian ini adalah ada pengaruh pemberian layanan informasi menggunakan teknik sosiodrama terhadap peran sosial peserta didik SMA Muhammadiyah 1 Metro Tahun Pelajaran 2029/2020. Saran sebaiknya kegiatan layanan bimbingan dan konseling guru BK sering memberikan layanan dalam pemahaman peran sosial peserta didik, agar lebih paham dengan peran yang dijalankan, memberikan layanan informasi terkait peran sosial kepada peserta didik agar mengetahui informasi tentang peran sosial dan menerapkan peran yang dijalankan.

The purpose of this study was to determine the effect of information services using sociodrama techniques on the social role of students of Muhammadiyah High School1 of Metro Academic Year in 2019/2020.This study uses a quantitative experimental design with One Group Pretest-Posttest Design. The study population was 159 with a total low social role of 19 students. The study sample numbered 19 students in total from the population. The instrument in data collection used a Likert scale model questionnaire method. Analysis of the data used is the t test. The results of the calculation of the data is obtained t-count = 59983 > 1,729 from the significance of 0.05, in addition it is known that an increase in pre-test scores of 88.9 and post-test of 115.8 resulting in an increase in scores of 22.2. It shows that information services using sociodrama techniques affect the social role of students.The conclusion of this study is that there is an effect of providing information services using sociodrama techniques on the social role of students of Muhammadiyah High School 1 of Metro in Academic Year 2019/2020. Suggestions should guidance and counseling service activities given by counseling teacher often provide services in understanding the social role of students, so that they are more familiar with the roles being carried out, providing information services related to social roles to students in order to know information about social roles and implement the roles played.
KARAKTERISTIK SPEKTRUM GETARAN MESIN BOR LISTRIK DENGAN KONDISI TANPA DAN DENGAN BEBAN
Authors: MUSLIM AZIS 
Published: February 2024

Penelitian difokuskan pada penggunaan sensor getaran accelerometer di Hand-Phone (HP) dimana dilihat respon dinamis sensor tersebut berdasarkan spektrum yang dihasilkan dari data domain waktu menjadi data domain frekuensi dengan menggunakan transformasi fourier yang dilakukan pada PC. Objek penelitian adalah mesin listrik yaitu bor listrik sebagai sumber getaran dengan sistem akuisisi data spektrum analyzer getaran berbasis HP-PC untuk mengetahui karakteristik ketika tanpa dan dengan beban. Frekuensi kerja mesin listrik bor dalam keadaan tanpa beban adalah 40Hz dibawah frekeuensi PLN yang sebesar 50Hz. Respon frekuensi juga dapat memperlihatkan karakteristik ketika bor listrik dioperasikan dengan adanya beban.Kata kunci:getaran, accelerometer, smart-phone, antarmuka, PC
Comparison of the Parameters of Textile Antennas Manufactured Using Three Techniques: Magnetron Sputtering, Ink-Jet Printing and Embroidery
Authors: Nowak Iwona , Januszkiewicz Łukasz , Krucińska Izabella 
Published: February 2024

Abstract
In this work, three textile antennas with the same geometry were produced using three different technologies: magnetron sputtering (PVD), ink-jet printing and embroidery using electroconductive yarn. In all three cases, the electrically conductive medium was the same, which was silver, known for centuries for its very good conductive properties. In order to show how the method of manufacturing antennas affects their operational parameters, the following measurements were carried out: surface resistivity, impedance, standing wave coefficient of antenna radiators, and their radiation characteristics were assessed. The surface resistivity value of the antenna paths obtained ranged from 0.05 to 1.2 Ωm/m.
Evaluation of Problems While Marketing Clothing on Instagram with the Pythagorean Fuzzy AHP Method
Authors: Özbek Ahmet 
Published: February 2024

Abstract
Due to the fierce international competition in today’s clothing market, businesses have started to pay more attention to marketing activities. One of the most popular of these marketing activities is Instagram marketing. For this reason, the aim of this study was to identify the problems faced by clothing businesses that perform garment marketing on Instagram, to rank them in order of importance and to develop solutions to the most important problems. Within the scope of the research, firstly, the problems encountered by businesses while marketing clothing on Instagram were determined through data obtained from 14 businesses through a designed questionnaire. The problems identified are technical problems, cargo-related problems, difficulty in increasing the number of followers, and various other issues. Secondly, all the problems identified in the research were ranked by the Pythagoras Fuzzy AHP Method according to the degree of importance; increasing the number of followers, technical problems, lack of trust and others. In the last stage of the research, expert opinion from Instagram marketing experts of 14 businesses was used to develop solutions to the three most important problems previously identified. The solution suggestions developed are as follows: to increase the number of followers of businesses, to increase the number and variety of advertisements and to make advertising campaigns continuous; for technical problems - to share purchase links to customers, to keep the programs used constantly updated, to get professional support and to focus more on story ads instead of post ads; and for the problem of lack of trust - honesty, phenomenon support, product photo shoots within the business.