bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Assessment of Novel (Bncs Formulation) against Brain Tumor
Authors: Mishra Anuradha , Ahmad Afza , Ansari Irfan Ahamad , Tiwari Rohit Kumar 
Published: January 2024

Background:
Oxidative stress refers to non-homeostatic elevation within intracellular
reactive oxygen species (ROS) levels and is associated with several neuro-related pathological
conditions. Diclofenac is a commonly prescribed non-steroidal anti-inflammatory drug
(NSAID) for treating aches and pain by reducing inflammation. Diclofenac is also associated
with the induction of apoptotic cell death by altering the homeostatic balance within mitochondria.
In the present report, the neuroprotective effects of BNC formulation constituted by Bacopa
monnieri leaves, Nigella sativa and Curcuma longa rhizome seeds were investigated.

Methods:
The synthesized formulation was characterized using FT-IR and LC-MS along with
organoleptic evaluation. Thereafter neuroprotective efficacy of BNC formulation was subsequently
investigated against Diclofenac-induced oxidative stress in SH-SY5Y cells. The cells
were pretreated with synthesized formulation and subsequently evaluated for amelioration in
Diclofenac-induced cytotoxicity, and ROS augmentation. The neuroprotective effect of synthesized
formulation was further explored by evaluating the changes in nuclear morphology, and
apoptosis alleviation with concomitant regulatory effects on caspase-3 and -9 activation.

Results:
Diclofenac was found to be considerably cytotoxic against human neuroblastoma SHSY5Y
cells. Intriguingly, Diclofenac-mediated toxicity was reduced significantly in SH-SY5Y
cells pretreated with BNC formulation. Augmented ROS levels within Diclofenac-treated SHSY5Y
cells were also reduced in the BNC formulation pretreated SH-SY5Y cells. Furthermore,
BNC formulation pretreated SH-SY5Y cells also exhibited reduced dissipation of mitochondrial
membrane potential, caspase-3 and -9, along with apoptosis after Diclofenac treatment.

Conclusion:
These findings indicated that, indeed, Diclofenac induces considerable ROSmediated
apoptosis in SH-SY5Y cells, which further intriguingly ameliorated Diclofenacmediated
cytotoxic effects on SH-SY5Y cells. This manuscript further collected information
about available National and International patents published or granted in preparation of and
thereof applications against motor and non-motor brain dysfunctions.
Vestibular disorders in blast injuries: additional symptoms
Authors: Byelyavsky S.K. , Borysov B.M. , Lutsenko V.I. , Trinus K.F. , Shipilo L.M. , Trishchynska M.A. 
Published: January 2024

Previously, we showed that Anti-Terrorist Operation (ATO) participants had significant complaints of vestibular disturbances, objective and subjective vertigo, kinetosis. One hundred and ten patients were examined, including 65 participants of ATO with mild traumatic brain injury (mTBI), 44 non-ATO without mTBI. The questionnaire “Types of dizziness” was used according to the International Clinical Protocol for Vertigo Disorders (Dizziness). Complaints of optokinetic nystagmus (OKN) were found in 27 (43.08 %) ATO and 7 (15.91 %) non-ATO patients, F-test = = 0.04, T-test = 0.0026. Thus, complaints of OKN turned out to be a specific feature of patients with blast injury syndrome. Complaints of nausea were detected in 38 (58.46 %) ATO and 11 (25.00 %) non-ATO patients, F-test = 0.38, T-test = 0.00035, indicating that this complaint is present and quantitatively more pronounced in ATO patients, but it is not specific for patients with mTBI. Complaints of vomiting were found in 19 (29.23 %) ATO and 11 (13.64 %) non-ATO patients, F-test = 0.055, T-test = 0.046, showing that this complaint is not typical for patients with mTBI. Complaints of anxiety without a reason were detected in 35 (53.85 %) ATO and 15 (34.09 %) non-ATO patients, F-test = 0.75, T-test = 0.041. Thus, this complaint is present and quantitatively more significant in ATO patients. Complaints of blackout were found in 41 (63.08 %) ATO and 16 (36.36 %) non-ATO patients, F-test = 0.98, T-test = 0.006, demonstrating that this complaint is present and quantitatively more pronounced in ATO patients, but it is not specific for patients with mTBI. Complaints of depression and numbness did not differ reliably according to the statistical indicators used. There were certain correlations. OKN: with scotomas in migraine headaches, kinetoses, descendophobia, and nyctophobia. Nausea: with severity of dizziness, vomiting episodes, blackouts, migraine headaches, increased heart rate, kinetoses, nyctophobia, claustrophobia. Vomiting: with ascendophobia, migraine headaches, increased heart rate. Anxiety without a reason: with impaired movement coordination, depression, blackouts, hyperacusis, weather sensitivity, ascendophobia. Depression without a reason: with subjective vertigo, agoraphobia, blackouts, numbness, throbbing headaches, weather sensitivity, electromagnetic hypersensitivity, increased heart rate. Blackouts: with weight gain, objective vertigo, orthostatic and throbbing headache. Numbness: with dizziness and its severity, agoraphobia, ascendophobia, migraine headaches and increased heart rate. Correlations are discussed from the point of view of vestibular dysfunction.
UMA ANÁLISE QUANTITATIVA SOBRE O ESTADO TRÓFICO EM RESERVATÓRIOS NO CEARÁ, SEMIÁRIDO BRASILEIRO
Authors: Rodrigues Ferreira Luciana Kamila , Cardoso Freitas Luciane Mara , Ribeiro Lima Gustavo Ross , Limaverde de Araújo Andrea , Araújo da Silva Fernando José 
Published: January 2024

O grau de eutrofização de estruturas lênticas artificiais localizadas em região do semiárido brasileiro foi investigado. Foram considerados 14 reservatórios com coletas de amostras trimestralmente no período de 2015 a 2021. As variáveis de estudo compreenderam a fração de volume disponível (VD) no dia de coleta, pluviometria (PP), nitrogênio total (N), fósforo total (P), clorofila a (Cla), transparência (Z) e densidade de cianobactérias (CB). Foi determinado o Índice de Estado Trófico (IET) nos reservatórios. Também, entre as informações do estudo efetuaram-se análise bivariada (através de correlações) e multivariada (através de Análise de Componentes Principais). Os valores de IET mostram carácter Eutrófico e que os resultados anuais podem ser baseados em média aritmética ou geométrica. As variáveis de associação climática (VD e PP) apresentaram efeito negativo sobre o acúmulo de nutrientes, com consequente incremento de eutrofização. A análise multivariada sugere resultados semelhantes. Entretanto, fenômenos no interior dos reservatórios parecem ser mais fortes que os de clima. Os resultados mostraram que a densidade de cianobactérias é potencializada por razões N:P < 20 e tem associação não relevante com as variáveis climáticas.
Analisis Kualitas Dodol dengan Bahan Campuran Tepung Kulit Manggis
Authors: Devi Ayu Ade Risma , Koeswiryono Dika Pranadwipa 
Published: January 2024

Dodol merupakan salah satu makanan atau bisa disebut jajanan khas Indonesia, berasal dari daerah Jawa Barat dengan bahan dasar pembuatannya adalah tepung beras ketan, santan dan gula. Tujuan dari penelitian Dodol dengan Bahan Campuran Tepung Kulit Manggis ini adalah untuk mengetahui kualitas Dodol yang berbahan campuran tepung kulit manggis dari segi rasa, aroma, tekstur dan warna, kemudian untuk mengetahui daya tahan serta menganalisis seberapa besar biaya yang diperlukan dalam pembuatan dodol berbahan campuran tepung kulit manggis. Waktu penelitian Januari 2022-Juli 2022. Pendekatan penelitian yang digunakan adalah penelitian eksperimen, penelitian eksperimen ini dilakukan dengan membuat dodol berbahan campuran tepung kulit manggis, kemudian diuji oleh 15 panelis dengan tes organoleptik, observasi, dan analisis biaya. Jenis penelitian ini menggunakan 3 perlakuan yaitu, perlakuan 0 (P0) Dodol tanpa bahan campuran tepung kulit manggis, perlakuan 1 (P1) Dodol dengan campuran tepung kulit manggis sebanyak 15%, perlakuan 2 (P2) Dodol dengan campuran tepung kulit manggis sebanyak 30%. Hasil akhir yang didapat adalah dodol berbahan campuran tepung kulit manggis memiliki rasa, aroma dan warna yang memuaskan, dan juga memiliki tekstur yang kenyal. Memiliki daya tahan selama 30 hari pada suhu ruangan dan masyarakat menyukai dodol dengan perlakuan (P2) sebanyak 30% campuran tepung kulit manggis.

Dodol is one of the typical Indonesian foods, originating from the West Java area with the basic ingredients of making it glutinous rice flour, coconut milk and sugar. The purpose of this research is to determine the quality of Dodol which is made from a mixture of mangosteen rind flour in terms of taste, aroma, texture and color, then to determine the durability and analyze how much cost is required in making dodol made from a mixture of flour. mangosteen skin. The research time is January 2022-July 2022. The research approach used is experimental research, this experimental research was carried out by making dodol made from a mixture of mangosteen rind flour, then tested by 15 panelists with organoleptic tests, observations, and cost analysis. This type of research uses 3 treatments, namely, treatment 0 (P0) Dodol without a mixture of mangosteen rind flour, treatment 1 (P1) Dodol with a mixture of 15% mangosteen rind flour, treatment 2 (P2) Dodol with a mixture of 30% mangosteen rind flour . The final result obtained is that dodol made from a mixture of mangosteen rind flour has a satisfying taste, aroma and color, and also has a chewy texture. It has a shelf life of 30 days at room temperature and people like lunkhead with treatment (P2) as much as 30% of the mangosteen peel flour mixture.
Erdogan's Foreign Policy Against Kurds in Syria: A Turkish Military and Political Strategy
Authors: Setiawati Diana , Enno Haya Gladya Naranta  
Published: January 2024

The situation in the Middle East is complicated by the need for Turkey to formulate a new military and political strategy . Relations between the Kurds and Turkey since the collapse of the Ottoman caliphate have been strained by the Kurds' desire for autonomous power. Until now, Kurds are still struggling to gain this legitimacy and are transforming into radical and separatist groups. Turkey under Erdogan's leadership underwent political reform from secular to democratic Islam. This includes changing Turkey's strategy to deal with Kurdish militias in Syria because Kurdish militias in Syria are considered dangerous by forming the PKK. The PKK occupies Syria's border with Turkey, so Erdogan devised a special military and political- strategic framework to stem the power of Kurdish militias. Since Turkey was ruled by Recep Tayyip Erdogan, Turkey's foreign policy has used the concept of "strategic depth" which is essential "zero problems with neighbors". Turkey in the Erdogan era tries to represent a modern and Muslim country that encourages democracy and social justice. This affected the perspective and strategy of Turkey being used to paralyze the Kurds. In the political strategy, Turkey conducts relations with various state and non-state actors to be able to exert influence at the international level. This research aims to know how Erdogan’s foreign policy against Kurd in Syria. This research method is using normative legal research with data analyzing using case approach. This research will explain on; a) The conflict between Turkey and Kurds, b) Characteristics of Erdogan's Government, c) Turkey's Involvement in the Syrian Conflict. This research finding will be the discussion analysis on Turkey's Military and Political Strategy against Kurds in Syria and Implications of Military and Political Strategy.
Contemporary International Treaties Seen From the Principles of Maqasid Ash-Shariah
Authors: Nugraha Amal Teguh 
Published: January 2024

Along with the times, the pattern of human interaction continues to evolve. Finally the human communication penetrates the boundaries of nation and state. The pattern which forms the inevitable urgency produces an International Treaties. However, an international treaty in Islam could be accepted if it is in line with Islamic Law, then it is processed into Maqasid Ash-Shariah. This research includes two important issues, ''Islamic relation and global society" and "the existence of Maqashid principles in contemporary International Treaties". This research is normative juridical legal research. It used a conceptual approach, comparative and statutory. From this discussion, it is concluded that the contemporary international treaties mostly contains Maqasid Asy-sharia principles, even a product of an international agreement can be accepted even though the agreement was not initiated by an Islamic country or Muslims.
Choosing Not to Have Children in the Perspective of Hadits and Maslahah
Authors: Asrori Khozinatul 
Published: January 2024

Salah satu tujuan pernikahan adalah untuk memiliki anak. Seiring waktu, memiliki anak tidak lagi menjadi tujuan dalam pernikahan, hal ini disebabkan oleh faktor-faktor yang mendasar baik secara internal maupun eksternal. Artikel ini bertujuan untuk menjelaskan posisi fenomena childfree dalam pandangan maslahah dan hubungannya dengan hadis yang menjelaskan anjuran untuk menambah keturunan. Penelitian ini adalah penelitian kepustakaan dengan menggunakan metode analisis deskriptif. Dalam hadis yang diriwayatkan oleh Imam Ahmad, terdapat nasihat dalam pernikahan untuk memilih wanita yang penuh cinta dan kasih sayang serta wanita yang subur dengan tujuan dan niat untuk menciptakan generasi berkualitas. Bagi Muslim yang memiliki komitmen untuk tidak memiliki anak setelah menikah, perlu dipertimbangkan apakah pilihan tersebut didasarkan pada dharurot atau tidak, jika terkait dengan hadis mengenai anjuran untuk menambah jumlah keturunan, pilihan untuk tidak memiliki anak setelah menikah (childfree) dianggap makruh. Namun, jika terdapat faktor-faktor lain yang bersifat dhoruriyah, seperti ancaman terhadap kelangsungan hidup, maka status hukum childfree dapat berubah, yang awalnya makruh menjadi diperbolehkan karena 'ilat' di baliknya.

One of the goals of marriage is to have children. Over time, having children is no longer a goal in marriage, this is due to the underlying factors both internally and externally. This article aims to explain the position of the childfree phenomenon in the view of maslahah and its relation to the hadith which explains the recommendation to increase offspring. This research is a literature research using descriptive analysis method. In the hadith narrated by Imam Ahmad there is advice in marriage to choose women who are filled with love and affection as well as women who are fertile with the aim and intention of trying to create a quality generation. For Muslims who have a commitment not to have children after marriage, it is necessary to consider whether the choice is based on dharurot or not, if it is related to the hadith regarding the recommendation to increase the number of offspring, the choice not to have children after marriage (childfree) is considered makruh . Nevertheless, if there are other factors that are dhoruriyah in nature , such as the threat of survival, then the legal status of childfree can change, which was originally makruh to become permissible due to the 'ilat' behind it.
Implementation of Informed Consent by HealthCare Professionals to Ensure Patient Safety in Hospitals
Authors: Muhammad Nur Aji Basuki  , Yuspin Wardah 
Published: January 2024

Penyelenggaraan pelayanan kesehatan dapat dipandang dari tiga subyek yaitu Pemakai, Penyelenggara, serta Penyandang dana pelayanan kesehatan. Bagi pemakai jasa pelayanan kesehatan, kualitas pelayanan lebih terkait pada dimensi ketanggapan petugas memenuhi kebutuhan pasien, kelancaran komunikasi petugas dengan pasien. Pelaksanaan Informed Consent haruslah mencerminkan asas umum pemerintahan yang baik karena hal tersebut berkaitan terhadap administrasi pemerintah. hal tersebut perlulah diperhatikan karena untuk menjaga marwah profesi kedokteran dan/ atau tenaga kesehatan, marwah rumah sakit penyedia layanan serta marwah hak dari pasien itu sendiri. Keadaan gawat darurat Informed consent tetap merupakan hal yang paling penting walaupun prioritasnya diakui paling bawah. Prioritas yang paling utama adalah tindakan menyelamatkan nyawa. Budaya keselamatan yang kuat tidak hanya menjadi inti untuk mengurangi bahaya terhadap pasien, tetapi juga penting untuk menyediakan lingkungan kerja yang aman bagi petugas kesehatan.

The implementation of health services can be seen from three subjects, namely Users, Organizers, and Presentation of health funds. For health service users, service quality is more related to the dimensions of staff responsiveness in meeting patient needs, smooth communication between staff and patients. The implementation of Informed Consent must reflect good general governance because it is related to government administration. This needs to be taken into account because it is to maintain the dignity of the medical profession and/or health workers, the dignity of the hospital providing services and the dignity of the rights of the patients themselves. emergency department Informed consent The situation remains the most important thing even though the priority is acknowledged to be the lowest. The most important priority is action to save lives. A strong safety culture is not only central to reducing harm to patients, but is also essential to providing a safe work environment for healthcare workers.
Dinamika Kelompok Wanita Tani Di Kota Bandar Lampung
Authors: Riyansyah Muhammad , K. Rangga Kordiyana , Effendi Irwan , Silviyanti Serly 
Published: January 2024

Tujuan penelitian adalah untuk mengetahui tingkat dinamika kelompok wanita tani di Kota Bandar Lampung. Penelitian ini dilakukan di Kota Bandar Lampung. Pengambilan data pada penelitian ini dilakukan pada bulan Februari 2022. Responden pada penelitian ini adalah 75 orang yang tergabung dalam kelompok wanita tani yang dilakukan secara acak proporsional untuk anggota kelompok wanita tani. Penelitian ini menggunakan metode analisis deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa tingkat dinamika kelompok wanita tani di Kota Bandar Lampung dinamika kelompok wanita tani (KWT) di Kota Bandar Lampung tergolong dalam kategori cukup dinamis, akan tetapi dalam aspek agenda terselubung berada dalam klasifikasi rendah dengan persenrase 86,67 persen atau 65 orang responden anggota KWT di Kota Bandar Lampung hal tersebut disebabkan oleh banyaknya anggota KWT tidak mengetahui yang dimaksud dengan agenda terselubung, mereka menjadi anggota KWT hanya untuk mencapai tujuan KWT. Hasil penelitian menunjukkan dari 10 KWT terdapat tiga KWT yang memiliki kedinamisan cukup dinamis yaitu KWT sukawangi sejahtera, KWT makmur dan KWT anggrek, sedangkan 7 KWT lainnya masuk dalam kategori dinamis. Pengukuran dinamika kelompok menggunakan 9 indikator yaitu : tujuan kelompok jelas dengan persentase 62,67 persen, struktur kelompok tahu dengan persentase 74,67 persen, fungsi tugas kelompok puas dengan persentase 62,67 persen, pembinaan dan pengembangan kelompok Puas dengan persentase 64,00 persen, kekompakkan kelompok puas dengan persentase 65,34 persen, suasana kelompok nyaman dengan persentase 58,66 persen, tekanan pada kelompok sedang dengan persentase 81,33 persen, keefektifan kelompok cukup efektif dengan persentase 90,67 persen, dan agenda terselubung rendah dengan persentase 86,67 persen.
Analisis Visual Kemasan Kue Gabin Samarinda Untuk Pengembangan Desain Kemasan
Authors: Hidayanto Andi Farid , Atmono Yohanes Firananta Setyo 
Published: January 2024

Heritage typical traditional food is the region typical food that is different from those from other regions. In carrying it, the food needs a container in the form of packaging. As a souvenir, the packaging needs to have a uniqueness that can differentiate it from other packages and at the same time can show its identity. One of the difference comes from the attributes of the packaging from the visual side. Because the visual appearance is the first thing that catch the costumers attention and also influences purchasing decisions. So it needs to be analyzed what attributes are required from the visual side.
This is a qualitative reasearch. Preliminary data were obtained from a literature study on food packaging design which was analyzed for its attributes, the results were qualitativeized using the NVivo application. NVivo is used to illustrate the decision analysis results framework by coding the data according to the classification scheme.
The result of this study is the arrangement of the visual attributes of traditional food packaging, which will be applied to develop the packaging design for the Samarinda gabin biscuit, to reconstruct the packaging which is suitable to current taste without losing its original identity.
The perioral muscular phenomenon: Part II.
Authors: Frederick Sidney 
Published: January 2024

Abstract
Over twenty-five years of studying the perioral musculature, clinical observation of the dental and peridental tissues of hundreds of patients, and examining seven anatomy books — have revealed that there is a serious deficiency in our knowledge of this musculature and its effects on the dental tissues and this part of the face. Believed to be of no unusual significance, it has been almost ignored through the years. One hears vague terms such as lip pressure and cheek pressure; but no comprehensive studies of this musculature, how it functions and the effects of these functions are to be found in literature. By its actions, this musculature effects many phases of dentistry, directly or indirectly; and orthodontics is affected most of all. By its manipulations of the dental tissues, the alveolar bone and gingiva, it ultimately determines the position of the teeth. Almost every person exhibits pressure signs or damage to the tissues. The only exceptions are babies. By reading these signs, the strength and physical configuration of the pertinent parts of the musculature can be determined. This ability to ‘read the signs’ should be developed since it helps fine tune the diagnostic process. Only by this means may the correct surgical procedures be carried out. A representative sample from over 1200 cases treated in this manner in more than twenty years will be shown.
Analysis of activator treatment changes
Authors: Hashim Hanizah Aman 
Published: January 2024

AbstractThe effects of functional appliance treatment have been reported in numerous studies in the literature with great variability in the findings. It is generally agreed that they can be used successfully to treat Class II malocclusions in growing and cooperative patients. However, there is a lack' of consensus regarding the relative orthodontic and orthopedic correction obtained by functional appliances in Class II correction. Lateral cephalometric radiographs from a sample (n=36) of patients who had undergone a phase of treatment with activator appliances were measured and analysed for changes using a modified version of the method described by Johnston (Hashim and Godfrey 1990). In this method, the treatment changes were broken down into: tooth movement relative to basal bone; and the translatory growth of the jaws, both with respect to the cranial base and to each other. The results show that the treatment effects were mainly dentoalveolar. There was a slight orthopedic effect on the maxilla, but no significant mandibular growth was observed, above that which can be expected from normal growth.