bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Fracture Resistance among Different Post Placement Strategies and Core Build-up Materials in Endodontically Treated Maxillary Premolars: In Vitro Study
Authors: Alshali Shatha , Mously Hisham , Abulhamael Ayman , Shikdar Narmeen 
Published: January 2024

Abstract

Objectives: The aim was to compare the fracture resistance of endodontically treated premolars reinforced by one or two fiber-reinforced composites and different core build-up materials. Materials and methods: 40 double rooted maxillary premolars were collected and divided into four groups (n=10). After endodontic treatment, teeth were prepared and received fiber posts as follow: group #1: single fiber post with Luxacore Z as luting cement and core build-up material, group #2: two fiber posts with Luxacore Z as luting cement and core build-up material, group #3: single fiber post cemented with RelyX Unicem followed by packable composite as a core build-up material, group #4: two fiber posts cemented with RelyX Unicem followed by packable composite as a core build-up material. The specimens were placed in the Universal testing machine for testing of the fracture resistance. Specimens were axially loaded on the center of the occlusal surface. Results: Group 4 (two fiber posts with resin cement & packable composite resin) had significantly higher fracture resistance (1051.7 N) compared to group 1 and 2 (single and double posts with luxacora Z build up) respectively at p-value < 0.05. Conclusion: The restoration of endodontically treated double rooted premolars using two fiber posts luted with resin cement, followed by packable composite build up showed promising performance regarding fracture-resistance.
Investigating perceptions and attitude toward telenursing among undergraduate nursing students for the future of nursing education: A cross-sectional study
Authors: Mun Minji , Choi Subin , Woo Kyungmi 
Published: January 2024

Abstract
Background
Telenursing is poised to emerge as a novel healthcare delivery system in the digital age. Hence, understanding nursing students' perspectives and readiness is pivotal for its effective implementation. This study investigated nursing students' perceptions regarding and attitudes toward telenursing and the factors that influenced their attitudes based on the technology acceptance model.
Methods
This study used a cross-sectional descriptive approach. The participants were nursing students (first to fourth year) enrolled in the College of Nursing in Korea. Differences in attitudes toward telenursing were analyzed using independent t-test and one-way analysis of variance. Pearson’s correlation coefficient was used to examine the correlations between the main variables. Factors that influenced attitudes toward telenursing were analyzed using multiple regression.
Results
Of the participants, 65.4% lacked substantial awareness of telenursing and 19.1% had prior telenursing experience. Although prospects on telenursing indicated that 90.4% had an optimistic view, face-to-face nursing was heavily preferred for both satisfactory and favored healthcare delivery. Many cited the Internet as their source of knowledge, and only 18.6% had received telenursing education. Attitude toward telenursing was significantly more positive among those with telenursing education and experience and experience of observing telenursing during clinical practice. The regression model was statistically significant (F = 67.445, p < .000). Factors, such as perceived usefulness, social influence, innovativeness, and self-efficacy, influenced attitudes toward telenursing.
Conclusions
Nursing students exhibited a lack of substantial awareness of telenursing; however, they simultaneously displayed a positive outlook. This lack of comprehensive understanding could stem from the absence of formal education in telenursing. Understanding and utilizing the potential of telenursing could be significantly aided by nursing students' education and knowledge. Thus, including telenursing education in the nursing curriculum is necessary. The skills and knowledge required for telenursing clinical practice can be developed through telenursing education. Such preparedness will affect nurses’ attitudes and intentions and the quality of telenursing offered to patients in the future.
Value Added Decomposition of Iran's Gross Exports
Authors: Jahangard Esfandiar , Jahangard Alireza 
Published: January 2024

Abstract

The objective of this article is the implementation of various methodological approaches for decomposing the value-added of Iran's gross exports and calculating the differences in the results of these approaches in the Iranian economy. This paper provides a systematic analytical framework and evaluates different methodologies and their fundamental differences in the Iranian economy. The Borin, Mancini (2023) decomposition method, utilizing a resource-based approach and the perspective of the exporting country, is considered as the foundational analysis for the value-added decomposition in gross exports. The contribution of this paper can be summarized in the following four contexts: Firstly, it presents a brief overview of computations using various methodologies for the value-added decomposition of Iran's gross exports. Secondly, it utilizes inter-country input-output database (ICIO) for the year 2016, considering Iran, for empirical documentation. Thirdly, among the proposed theoretical frameworks, it focuses on the Borin, Mancini (2023) framework with a resource-based approach and the perspective of the exporting country. Fourthly, it provides a structural interpretation of all methods for the Iranian economy in 2016.
JEL Classification: D57, F14
Targeting mosquito X-chromosomes reveals complex transmission dynamics of sex ratio distorting gene drives
Authors: Papathanos Philippos , Haber Daniella , Arien Yael , Lamdan Lee , Alcalay Yehonathan , Zecharia Chen , Krsticevic Flavia , Yonah Elad , Avraham Rotem , Krzywinska Elzbieta , Krzywinski Jaroslaw , Marois Eric , Windbichler Nikolai 
Published: January 2024

Abstract

Engineered sex ratio distorters (SRDs) have been proposed as a powerful component of genetic control strategies designed to suppress harmful insect pests. Two types of CRISPR-based SRD mechanisms have been proposed: X-shredding eliminates X-bearing sperm, while X-poisoning eliminates daughters inheriting disrupted X-chromosomes. These differences can have a profound impact on the population dynamics of SRDs when linked to the Y-chromosome: an X-shredder is invasive constituting a classical meiotic Y-drive, whereas X-poisoning is self-limiting, unable to invade but also insulated from selection. Here, we established the first X-poisoning strains in the malaria vector Anopheles gambiae targeting three X-linked genes during spermatogenesis resulting in male bias. Surprisingly, we found that sex distortion was primarily driven by a loss of X-bearing sperm with limited evidence for postzygotic lethality of daughters. By leveraging a Drosophila melanogaster model, we show unambiguously that engineered SRD traits can operate differently in these two insects. Unlike X-shredding, X-poisoning could theoretically operate at early stages of spermatogenesis. We therefore explored premeiotic Cas9 expression to target the mosquito X-chromosome. We find that, by pre-empting the onset of meiotic sex chromosome inactivation, this approach may enable the development of Y-linked SRDs if mutagenesis of spermatogenesis-essential genes is functionally balanced.
The Effect of Telemedicine on Readmissions of Patients with Heart Failure and/or COPD: a Systematic Review
Authors: Stergiopoulos Georgios M. , Elayadi Anissa N. , Chen Edward S. , Galiatsatos Panagis 
Published: January 2024

Abstract

Background Hospital readmissions pose a challenge for modern healthcare systems. Our aim was to assess the efficacy of telemedicine incorporating telemonitoring technologies in decreasing hospital readmissions with a focus on specific patient populations particularly prone to rehospitalization: patients with heart failure (HF) and/ or chronic obstructive pulmonary disease (COPD) through a systematic review.
Methods Three major electronic databases, including PubMed, Scopus, and ProQuest’s ABI (Abstracted Business Information)/INFORM Global, were searched for trials employing telemedical technologies and quantifying the effect on the readmission rates in the HF and/or COPD populations. Our search was limited to English-language articles published between 2012 and 2022.
Results Eighteen scientific articles referencing seventeen different clinical trials were isolated. Most studies were randomized controlled trials and the readmission related outcome most studied was all-cause readmissions followed by HF and acute exacerbation of COPD readmissions. 47% of the studies suggested that telemedicine might decrease the readmission related burden, while most of the remaining studies suggested that telemedicine had a neutral effect on hospital readmissions. Comparative analysis of studies focusing on the COPD or HF populations resulted in the observation of a clearer association in the reduction of the readmission-related burden in patients with COPD compared to patients with HF (83% vs 27%). Data regarding other relevant outcomes often assessed including all-cause mortality emergency department visits, healthcare costs, quality of life, medication adherence and reconciliation were extracted and qualitatively assessed.
Conclusion This systematic review highlights the uncertainty surrounding the effectiveness of telemedicine in reducing the readmission rates of high-risk patients with chronic illnesses, with much of the uncertainty linked to the variability of the deliverable of telemedicine. Nonetheless, the fact that almost all trials found that patients receiving telemedicine benefited to some extent and the strong association in the reduction of readmissions in the COPD population are encouraging. Conduction of more high-quality studies is necessary to draw definitive conclusions.
Preoperative risk factors and cumulative incidence of temporary ileostomy non-closure after sphincter-preserving surgery for rectal cancer: a meta-analysis
Authors: He Fan , tang Chenglin , Yang Fuyu , Chen Defei , Xiong junjie , Zou yu , zhao Dongqin , Qian Kun 
Published: January 2024

Abstract
Background
Temporary ileostomy (TI) has proven effective in reducing the severity of anastomotic leakage after rectal cancer surgery; however, some ileostomies fail to reverse over time, leading to conversion into a permanent stoma (PS). In this study, we aimed to investigate the preoperative risk factors and cumulative incidence of TI non-closure after sphincter-preserving surgery for rectal cancer.
Materials and Methods
We conducted a meta-analysis after searching the Embase, Web of Science, PubMed, and MEDLINE databases from their inception until November 2023. We collected all published studies on the risk factors related to TI non-closure after sphincter-preserving surgery for rectal cancer.
Results
A total of 1610 studies were retrieved, and 13 studies were included for meta-analysis, comprising 3026 patients. The results of the meta-analysis showed that the identified risk factors included older age (p = 0.03), especially > 65 years of age (p = 0.03), male sex (p = 0.009), American Society of Anesthesiologists score ≥ 3 (p = 0.004), comorbidity (p = 0.001), and distant metastasis (p < 0.001). Body mass index, preoperative hemoglobin, preoperative albumin, preoperative carcinoma embryonic antigen, tumor location, neoadjuvant chemoradiotherapy, smoking, history of abdominal surgery, and open surgery did not significantly change the risk of TI non-closure
Conclusion
We identified five preoperative risk factors for TI non-closure after sphincter-preserving surgery for rectal cancer. This information enables surgeons to identify high-risk groups before surgery, inform patients about the possibility of PS in advance, and consider performing protective colostomy or Hartmann surgery.
WITHDRAWN: Investigation of Turbulence Flow Field and Pressure Pulsation in 3D Impeller Axial Pump Based on Inner Dynamic Simulation and Vibration Technique Analyses
Authors: Al-Obaidi Ahmed Ramadhan , Alhamid Jassim 
Published: January 2024

Abstract

The axial pump's big flow and low head features make it a popular choice for pumping station installationsThe purpose of this study is to determine how transiently changing flow circumstances affect the relative flow channel between the impeller and the flow field, thereby affecting pulsation. Through the use of physical model testing, the reliability of both experimental and numerical simulations of the device's flow channel was verified. The analysis conducted in the study focused on investigating the flow field and pressure pulsation characteristics of the impeller across different flow rates, while also exploring the impact of blade angle (-3°, 0°, and 3°) under five distinct operational conditions, ranging from optimal to flow conditions at best efficiency point (QBEP) plus value. According to the study, the axial pump's flow stability declined with decreasing flow rate, which resulted in increased pressure pulsations across various flow regions. Additionally, Most flow regions were affected by an increase in flow instability, levels of the pressure pulsation, and frequencies of the dominant rotor-stator interaction when the blade angle was increased from -3° to 3°. As a result of these findings, it may be possible to optimize axial flow pump device designs and enhance their stability. Furthermore, they are helpful for researchers and engineers interested in improving their understanding of pump flow dynamics.
Association of accelerometer-determined physical activity and sedentary behavior with the gut microbiome in middle-aged women: A compositional data approach
Authors: Pérez-Prieto Inmaculada , Migueles Jairo H. , Molina Nerea M. , Sola-Leyva Alberto , Salas-Espejo Eduardo , Arffman Riikka K. , Nurkkala Marjukka , Niemelä Maisa , Lüll Kreete , Org Elin , Franks Stephen , Tapanainen Juha S. , Salumets Andres , Piltonen Terhi T. , Ortega Francisco B. , Altmäe Signe 
Published: January 2024

Abstract

The beneficial effects of physical activity (PA) on gut microbiome have been reported, nevertheless the findings are inconsistent, with the main limitation of subjective methods for assessing PA. It is well-accepted that using an objective assessment of PA reduces the measurement error and allows also objective assessment of sedentary behavior (SB). We aimed to study the associations between accelerometer-assessed behaviors (i.e., SB, light-intensity physical activity -LPA- and moderate-to-vigorous physical activity -MVPA) with the gut microbiome using compositional data analysis, a novel approach that enables to study these behaviors accounting for their inter-dependency. This cross-sectional study included 289 women from the Northern Finland Birth Cohort 1966. Movement behaviors were measured during 14 days by wrist-worn accelerometers. Analyses based on the combined effect of MVPA and SB, and compositional data analyses in association with the gut microbiome data were performed. The microbial alpha- and beta-diversity were not significantly different between the MVPA-SB groups, and no differentially abundant microorganisms were detected. Compositional data analysis did not show any significant associations between increasing one behavior while proportionally reducing the others on microbial alpha-diversity. Butyrate-producing microbes such as Agathobacter and Lachnospiraceae CAG56 were significantly more abundant when reallocating time from LPA or SB to MVPA (γ = 0.609 and 0.113, both p-values = 0.007). While PA and SB did not seem to have a significant effect on microbial diversity, we found associations of these behaviors with specific gut bacteria, suggesting that PA of at least moderate intensity (i.e., MVPA) could exert beneficial effects on short-chain fatty acids-producing microbes.
Uptake and correlates of influenza vaccine among older adults residing in rural regions of China: a cross-sectional study
Authors: Zhao Peizhen , Xu Wenqian , Wang Jinshen , Liang Peng , Li Haiyi , Wang Cheng 
Published: January 2024

Abstract
Objectives
This study aimed to investigate the extent of influenza vaccine coverage and identify the factors influencing vaccine uptake among older adults in rural regions of China.
Design
A cross-sectional study utilizing convenience sampling was conducted.
Setting
Two rural sites in Guangdong Province.
Participants
Individuals needed to meet specific inclusion criteria: (1) attainment of 60 years of age or older; (2) originating from rural households; (3) demonstrating a voluntary desire to partake in the survey, either through written or verbal informed consent.
Outcome measure
The rate of influenza vaccination in the past year.
Results
A total of 423 participants were ultimately included in this study, with the majority falling within the age range of 60 to 75 years (81.3%). Only one-third of the participants had received an influenza vaccine in the past year (30.0%, 127 out of 423). Notably, more than half of the older adults exhibited no hesitancy towards influenza vaccination (54.9%, 232 out of 423). The multivariable analysis revealed that rural elderly individuals with a robust understanding of influenza vaccines and a positive attitude towards them (adjusted odds ratio [aOR] = 2.60, 95% confidence interval [CI]: 1.41–4.81), along with a high level of trust in vaccination service providers (aOR = 2.58, 95% CI: 1.01–6.63), were positively associated with receiving influenza vaccination in the past year.
Conclusion
This study reveals a low rate of influenza vaccine uptake among older adults residing in rural areas of China. Given the limited adoption of influenza vaccination and the significant threat it poses, there is an urgent imperative to devise precise interventions aimed at enhancing the effectiveness of influenza vaccination programs.
Immunoinflammatory Features and Cognitive Function in Treatment-Resistant Schizophrenia: Unraveling Distinct Patterns in Clozapine-Resistant Patients
Authors: Li Yanzhe , Zhu Minghuan , Dong Yeqing , Liu Nannan , Wang Xinxu , Yang Bing , Li Zezhi , Li Shen 
Published: January 2024

Abstract
Patients with treatment-resistant schizophrenia (TRS), particularly those resistant to clozapine (CTRS), pose a clinical challenge due to limited response to standard antipsychotic treatments. Inflammatory factors like tumor necrosis factor-alpha (TNF-α), interleukin 2 (IL-2), and interleukin 6 (IL-6) are implicated in schizophrenia's pathophysiology. Our study examines cognitive function, psychopathological symptoms and inflammatory factors in TRS patients, focusing on differences between CTRS and non-CTRS individuals, as well as healthy controls. A cohort of 115 TRS patients were recruited, assessing IL-2, IL-6 and TNF-α. The Positive and Negative Syndrome Scale (PANSS) was applied to assess psychopathological symptoms, while the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was applied to assess cognitive functioning. CTRS patients showed lower visuospatial constructional score (p = 0.015), higher PANSS scores, higher levels of IL-2 and reduced TNF-α than non-CTRS patients (p < 0.05). Notably, IL-2 was independently associated with psychopathology symptoms in CTRS patients (Beta = 0.268, t = 2.075, p = 0.042), while IL-6 was associated with psychopathology symptoms in non-CTRS patients (Beta = -0.327, t = -2.109, p = 0.042). Sex-specific analysis in CTRS patients revealed IL-2 associations with PANSS total and positive symptoms in females, and TNF-α associations with PANSS positive symptoms in males. Furthermore, IL-2, IL-6, and TNF-α displayed potential diagnostic value in TRS patients and CTRS patients (p < 0.05). Clozapine‑resistant symptoms represent an independent endophenotype in schizophrenia with distinctive immunoinflammatory characteristics, potentially influenced by sex.
Elucidating the Role of Pro-renin Receptors in Pancreatic Ductal
Adenocarcinoma Progression: A Novel Therapeutic Target in Cancer
Therapy
Authors: Aliakbarian Mohsen , Ferns Gordon A. , Mohamadzadeh Shabestari Mahmoud , Ahmadzadeh Amir Mahmoud , Abdollahzade Aref , Rahimi Hoda , Khodashahi Rozita , Arjmand Mohammad-Hassan 
Published: January 2024

Abstract:
Pancreatic cancer is a highly aggressive malignancy with a very poor prognosis. The 5-
year survival in these patients is very low, and most patients develop drug resistance to current
therapies, so additional studies are needed to identify the potential role of new drug targets for the
treatment of pancreatic cancer. Recent investigations have been performed regarding the roles of
pro-renin receptors (PRR) in the initiation and development of cancers. PRR is a component of
the local renin-angiotensin system (RAS). Local tissue RAS has been known in diverse organ systems,
including the pancreas. Various investigations have implicated that PRRs are associated
with the upregulation of various signaling pathways, like the renin-angiotensin system pathway,
PI3K/Akt/mTOR, and the Wnt-signaling pathways, to contribute to pathological conditions, including
cancer. In this review, we presented an overview of the role of PRR in the progression of
pancreatic adenocarcinoma.
The Upper-gastrointestinal Endoscopic Findings of People Living with
HIV: A Systematic Review
Authors: SeyedAlinaghi SeyedAhmad , Janfaza Nazanin , Mirzapour Pegah , Siami Haleh , Ali Zoha , Matini Parisa , Karimi Elaheh , Mahrokhi Sona , Varshochi Sanaz , Sanaati Foziye , Fathi Amrollah Masoomeh , Saki Sobhan , Mehraeen Esmaeil , Dadras Omid 
Published: January 2024

Objective:
This article aimed to analyze upper endoscopic findings in the HIV patient
population to elucidate the upper-gastrointestinal complications related to HIV infection. Gastrointestinal
(GI) disorders in individuals living with HIV/AIDS exhibit diverse and often nonspecific
manifestations, imposing substantial morbidity and mortality burdens. Endoscopic evaluation
with biopsies is essential in the diagnosis and management of these conditions. Delayed treatment
due to undetected GI abnormalities during endoscopic examinations can lead to poorer health outcomes.

Methods:
This systematic review has determined the findings of upper-GI endoscopy of HIV-infected
patients. Online databases of PubMed, Web of Science, Jisc Library Hub Discover, and Library
of Congress have been searched using relevant keyword combinations. We have retrieved
all the pertinent papers and reports published in English and screened them against inclusion/exclusion
criteria for data extraction in two steps. First, titles/abstracts have been evaluated and then
full-text screening has been performed by independent researchers. This study has adhered to the
Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist.

Results:
In this review, 24 articles have been included in the final analysis. The study has focused
on the characteristics of participants and the findings of endoscopic evaluations. The participants
of the study have been HIV-positive patients, and the majority of them have undergone endoscopy
due to gastrointestinal symptoms. The biopsy regions primarily targeted have been observed
to be the esophagus, stomach, and duodenum. The most common result of the biopsy specimens
has been chronic active gastritis.

Conclusion:
To improve clinical practice, this systematic review sought to provide an up-to-date
reference for upper gastrointestinal endoscopic findings of HIV-infected persons. Our results are
in line with earlier research showing how effective endoscopy is for determining a precise diagnosis
and directing care. The majority of HIV patients with gastrointestinal symptoms have been
found to have opportunistic infections and persistent active gastritis as well as mucosal abnormalities
of the upper gastrointestinal tract. Studies have shown that endoscopic and histological assessment
can aid in the early detection and management of issues involving the upper gastrointestinal
tract.