bluuebunny/crossref_metadata_2025_split huggingface dataset:
Box–Behnken design in optimizing heavy metal removal from wastewater using selenium hybridized graphitic carbon nitride nanocomposites
Authors: Mohamed Yasser M. A. , Elgohary Elzahraa A. , El Nazer Hossam A. 
Published: December 2023

AbstractIn this study Box–Behnken designs and response surface methodology (BBD-RSM) was used for optimizing heavy metal adsorption. The hazardous effect of wastewater on agriculture, animals and human as well makes its remediation is being considered a global challenge. Herein, a novel visible-light-responsive selenium-doped graphitic carbon nitride composites via the exfoliation of g-C3N4 polymer with different concentrations of selenium precursor (1 w%, 2.5 w%, 5 w%, with respect to the weight of g-C3N4) under ultrasound irradiation condition to produce the hybridized the corresponding polymeric nanocomposites (5%Se/g-C3N4), (10%Se/g-C3N4) and (25%Se/g-C3N4) denoted names C1, C2, C3; respectively. Full chracterization for the nanocomposites was performed using scanning electron microscope (SEM), X-ray diffraction (XRD), UV–Vis diffuse reflection spectroscopy. The as-prepared nanocomposites compared to pure g-C3N4 were applied in wastewater treatment for a real sample collected from Siwa Lake that suffered from increasing the heavy metal ions due to industrial drainage. Testing the catalytic activity of the prepared composites in treatment of wastewater sample collected from Siwa Lake in Egypt affected by the industrial drainage that was analyzed to determine the occurred polluted heavy metal ions. It was indicated that this sample contained Ca(II), Zn(II), Fe(II), Cu(II), Mn(II) and Cd(II) ions. The metal adsorption measurements were developed using atomic absorption spectroscopy (AAS) to show the removal efficiency of metal ions.
Clinical features that predict the mortality risk in older patients with Omicron pneumonia: the MLWAP score
Authors: Pei Yongjian , Li Ting , Chen Chen , Huang Yongkang , Yang Yun , Zhou Tong , Shi Minhua 
Published: December 2023

AbstractIn December 2022, the Chinese suffered widespread Omicron of SARS-CoV-2 with variable symptom severity and outcome. We wanted to develop a scoring model to predict the mortality risk of older Omicron pneumonia patients by analyzing admission data. We enrolled 227 Omicron pneumonia patients aged 60 years and older, admitted to our hospital from December 15, 2022, to January 16, 2023, and divided them randomly into a 70% training set and a 30% test set. The former were used to identify predictors and develop a model, the latter to verify the model, using the area under the receiver operating characteristic curve (AUC), the Hosmer–Lemeshow goodness-of-fit test, a calibration curve to test its performance and comparing it to the existing scores. The MLWAP score was calculated based on a multivariate logistic regression model to predict mortality with a weighted score that included immunosuppression, lactate ≥ 2.4, white blood cell count ≥ 6.70 × 109/L, age ≥ 77 years, and PaO2/FiO2 ≤ 211. The AUC for the model in the training and test sets was 0.852 (95% CI, 0.792–0.912) and 0.875 (95% CI, 0.789–0.961), respectively. The calibration curves showed a good fit. We grouped the risk scores into low (score 0–7 points), medium (8–10 points), and high (11–13 points). This model had a sensitivity of 0.849, specificity of 0.714, and better predictive ability than the CURB-65 and PSI scores (AUROC = 0.859 vs. 0.788 vs. 0.801, respectively). The MLWAP-mortality score may help clinicians to stratify hospitalized older Omicron pneumonia patients into relevant risk categories, rationally allocate medical resources, and reduce the mortality.
The left ventricular “lining” technique for repair of ischemic ventricular septal rupture
Authors: Katsumata Takahiro , Shimada Ryo , Uchida Hiroaki , Suzuki Tatsuya , Ozawa Hideki , Daimon Masahiro 
Published: December 2023

AbstractWe describe a technique to repair ischemic ventricular septal rupture via a left ventriculotomy. It employs a large endoventricular patch as a “lining” over the locally patched septal defect and the free wall defect which is going to be roofed with an external patch. Both defects are then closed in double layers, holding a single continuous patch. The technique enhances the advantage of the left ventriculotomy in the repair and minimizes ventriculotomy-related morbidity.
Bioorthogonal Chemistry in Cellular Organelles
Authors: Šlachtová Veronika , Chovanec Marek , Rahm Michal , Vrabel Milan 
Published: December 2023

AbstractWhile bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular organelles. These innovations hold great promise for therapeutic interventions in personalized medicine and precision therapies. We also address existing challenges related to the selectivity and trafficking of subcellular dynamics. Organelle-targeted bioorthogonal reactions have the potential to significantly advance our understanding of cellular organization and function, provide new pathways for basic research and clinical applications, and shape the direction of cell biology and medical research.
Defaulting peripherally inserted central catheter (PICC) orders to single lumen: A quality improvement initiative at a Midwestern academic center 2022–2023
Authors: Trautman Kathryn , Kobayashi Takaaki , McPherson Chad , Brust Karen 
Published: December 2023

Abstract
Defaulting the order for peripherally inserted central catheters (PICCs) placement to single lumen increased proportion of single-lumen insertions over total insertions from 42/126 (33%) to 57/104 (51)%. Single-lumen PICCs had a nonsignificant lower rate of central line-associated bloodstream infection compared to double-lumen PICCs.
Impact of the COVID-19 pandemic on the Thai population: Delineating the effects of the pandemic and policy measures
Authors: Kasatpibal Nongyao , Viseskul Nongkran , Untong Akarapong , Thummathai Kwaunpanomporn , Kamnon Kampong , Sangkampang Srisakul , Tokilay Rusila , Assawapalanggool Srisuda , Apisarnthanarak Anucha 
Published: December 2023

Abstract

Objectives:
This study aimed to determine the impacts of the COVID-19 pandemic and policy measures and delineate the impact of each on a cohort of Thai citizens.

Methods:
A cross-sectional study was conducted among 2,500 Thai people from October 2020 to January 2021. A questionnaire collecting demographic information and other data was sent to eligible subjects.

Results:
Overall, 51.6% and 49.5% of participants felt the impacts of COVID-19 and policy measures at the highest level, respectively. The study demonstrated that the weighted effect of the impact of the COVID-19 outbreak was statistically (p < .001) greater than that of policy measures on family (0.664 vs 0.618), education (0.562 vs 0.557), and the economy (0.643 vs 0.572). The weighted effect of the impact of policy measures was statistically (p < .001) greater than that of the COVID-19 pandemic on people’s daily activities (0.675 vs 0.651), cultural/traditional or community way of life (0.769 vs 0.736), access to healthcare services and infection prevention supplies (0.410 vs 0.390), and mental health (0.625 vs 0.584).

Conclusions:
About half of the participants had a high level of impact from both the COVID-19 pandemic and policy measures. The results of this study suggest that policy measures need to be judged with caution, and the government should provide more comprehensive support to reduce the impact on people’s lives.
Lim Ulrich sequences and Boij-Söderberg cones
Authors: Iyengar Srikanth B. , Ma Linquan , Walker Mark E. 
Published: December 2023

Abstract
This paper extends the results of Boij, Eisenbud, Erman, Schreyer and Söderberg on the structure of Betti cones of finitely generated graded modules and finite free complexes over polynomial rings, to all finitely generated graded rings admitting linear Noether normalizations. The key new input is the existence of lim Ulrich sequences of graded modules over such rings.
E-Polynomials of Generic -Character Varieties: Branched Case
Authors: Shu Cheng 
Published: December 2023

Abstract
For any branched double covering of compact Riemann surfaces, we consider the associated character varieties that are unitary in the global sense, which we call

$\operatorname {\mathrm {GL}}_n\rtimes \!<\!\sigma {>}$

-character varieties. We restrict the monodromies around the branch points to generic semi-simple conjugacy classes contained in

$\operatorname {\mathrm {GL}}_n\sigma $

and compute the E-polynomials of these character varieties using the character table of

$\operatorname {\mathrm {GL}}_n(q)\rtimes \!<\!\sigma \!>\!$

. The result is expressed as the inner product of certain symmetric functions associated to the wreath product

$(\mathbb {Z}/2\mathbb {Z})^N\rtimes \mathfrak {S}_N$

. We are then led to a conjectural formula for the mixed Hodge polynomial, which involves (modified) Macdonald polynomials and wreath Macdonald polynomials.
THE REBELLION OF CONSTITUTIONAL COURTS AND THE NORMATIVE CHARACTER OF EUROPEAN UNION LAW
Authors: Nagy Csongor Istvan 
Published: December 2023

AbstractThis article offers a reconstruction and assessment of the emerging rebellion of European constitutional courts against the exceptionless supremacy of European Union (EU) law. It presents the ontological theories of supremacy and how the Court of Justice of the EU (CJEU) overcame the first two major challenges of its history: the existential challenge of canonizing the general doctrine of supremacy and the Solange challenge of national fundamental rights. It provides an account of the emerging ultra vires challenge, including its root cause and evolvement, and provides an assessment and sets out proposals. The article demonstrates that the crux of the matter is not the primacy of EU law but the interpretive primacy of the CJEU. It argues that the rebellion was triggered by the perception that the CJEU case law features a declining normative and an increasing policy character. The debate about the CJEU's evolutionary interpretation, in a certain sense, parallels US constitutional law's debate between originalism and the living constitution, with the difference that the EU is a pluralist legal order.
Reducing ‘avoidable research waste’ in applied linguistics research: Insights from healthcare research
Authors: Isaacs Talia , Chalmers Hamish 
Published: December 2023

Abstract
This paper explores Chalmers and Glasziou's (2009) notion of ‘research waste’ from healthcare research to examine what it can offer the field of applied linguistics. Drawing on examples from both disciplines, we unpack Macleod et al.'s (2014) five research waste categories: (1) asking the wrong research questions, (2) failing to situate new research in the context of existing research, (3) inefficient research regulation/management, (4) failing to disseminate findings, and (5) poor research reporting practices. We advance this typology to help applied linguists identify and reduce avoidable research waste and improve the relevance, quality, and impact of their research.
Linking Water Age, Nitrate Export Regime, and Nitrate Isotope Biogeochemistry in a Tile‐Drained Agricultural Field
Authors: Yu Zhongjie , Hu Yinchao , Gentry Lowell E. , Yang Wendy H. , Margenot Andrew J. , Guan Kaiyu , Mitchell Corey A. , Hu Minpeng 
Published: December 2023

AbstractAccurately quantifying and predicting the reactive transport of nitrate () in hydrologic systems continues to be a challenge, due to the complex hydrological and biogeochemical interactions that underlie this transport. Recent advances related to time‐variant water age have led to a new method that probes water mixing and selection behaviors using StorAge Selection (SAS) functions. In this study, SAS functions were applied to investigate storage, water selection behaviors, and export regimes in a tile‐drained corn‐soybean field. The natural abundance stable nitrogen and oxygen isotopes of tile drainage were also measured to provide constraints on biogeochemical transformations. The SAS functions, calibrated using chloride measurements at tile drain outlets, revealed a strong young water preference during tile discharge generation. The use of a time‐variant SAS function for tile discharge generated unique water age dynamics that reveal an inverse storage effect driven by the activation of preferential flow paths and mechanically explain the observed variations in isotopes. Combining the water age estimates with isotope fingerprinting shed new light on export dynamics at the tile‐drain scale, where a large mixing volume and the lack of a strong vertical contrast in concentration resulted in chemostatic export regimes. For the first time, isotopes were embedded into a water age‐based transport model to model reactive transport under transient conditions. The results of this modeling study provided a proof‐of‐concept for the potential of coupling water age modeling with isotope analysis to elucidate the mechanisms driving reactive transport.
Ferritinophagy: research advance and clinical significance in cancers
Authors: Wang Jiewen , Wu Nayiyuan , Peng Mingjing , Oyang Linda , Jiang Xianjie , Peng Qiu , Zhou Yujuan , He Zuping , Liao Qianjin 
Published: December 2023

AbstractFerritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear receptor coactivator 4 (NCOA4), entails the recognition of ferritin by NCOA4 and subsequent delivery to the autophagosome. Within the autophagosome, ferritin undergoes degradation, leading to the release of iron in the lysosome. It is worth noting that excessive iron levels can trigger cell death. Recent evidence has elucidated the significant roles played by ferritinophagy and ferroptosis in regulation the initiation and progression of cancer. Given the crucial role of ferritinophagy in tumor biology, it may serve as a potential target for future anti-tumor therapeutic interventions. In this study, we have provided the distinctive features of ferritinophagy and its distinctions from ferroptosis. Moreover, we have briefly examined the fundamental regulatory mechanisms of ferritinophagy, encompassing the involvement of the specific receptor NCOA4, the Nrf2/HO-1 signaling and other pathways. Subsequently, we have synthesized the current understanding of the impact of ferritinophagy on cancer progression and its potential therapeutic applications, with a particular emphasis on the utilization of chemotherapy, nanomaterials, and immunotherapy to target the ferritinophagy pathway for anti-tumor purposes.
CB2 regulates oxidative stress and osteoclastogenesis through NOX1-dependent signaling pathway in titanium particle-induced osteolysis
Authors: Tao Huaqiang , Li Xueyan , Chu Miao , Wang Qiufei , Li Ping , Han Qibin , Chen Kai , Zhu Pengfei , Hao Yuefeng , Yang Xing , Geng Dechun , Gu Ye 
Published: December 2023

AbstractPeriprosthetic osteolysis (PPO) induced by wear particles at the interface between the prosthesis and bone is a crucial issue of periprosthetic bone loss and implant failure. After wear and tear, granular material accumulates around the joint prosthesis, causing a chronic inflammatory response, progressive osteoclast activation and eventual loosening of the prosthesis. Although many studies have been conducted to address bone loss after joint replacement surgeries, they have not fully addressed these issues. Focusing on osteoclast activation induced by particles has important theoretical implications. Cannabinoid type II receptor (CB2) is a seven-transmembrane receptor that is predominantly distributed in the human immune system and has been revealed to be highly expressed in bone-associated cells. Previous studies have shown that modulation of CB2 has a positive effect on bone metabolism. However, the exact mechanism has not yet been elucidated. In our experiments, we found that NOX1-mediated ROS accumulation was involved in titanium particle-stimulated osteoclast differentiation. Furthermore, we confirmed that CB2 blockade alleviated titanium particle-stimulated osteoclast activation by inhibiting the NOX1-mediated oxidative stress pathway. In animal experiments, downregulation of CB2 alleviated the occurrence of titanium particle-induced cranial osteolysis by inhibiting osteoclasts and scavenging intracellular ROS. Collectively, our results suggest that CB2 blockade may be an attractive and promising therapeutic scheme for particle-stimulated osteoclast differentiation and preventing PPO.
Fast and scalable production of crosslinked polyimide aerogel fibers for ultrathin thermoregulating clothes
Authors: Xue Tiantian , Zhu Chenyu , Yu Dingyi , Zhang Xu , Lai Feili , Zhang Longsheng , Zhang Chao , Fan Wei , Liu Tianxi 
Published: December 2023

AbstractPolyimide aerogel fibers hold promise for intelligent thermal management fabrics, but their scalable production faces challenges due to the sluggish gelation kinetics and the weak backbone strength. Herein, a strategy is developed for fast and scalable fabrication of crosslinked polyimide (CPI) aerogel fibers by wet-spinning and ambient pressure drying via UV-enhanced dynamic gelation strategy. This strategy enables fast sol-gel transition of photosensitive polyimide, resulting in a strongly-crosslinked gel skeleton that effectively maintains the fiber shape and porous nanostructure. Continuous production of CPI aerogel fibers (length of hundreds of meters) with high specific modulus (390.9 kN m kg−1) can be achieved within 7 h, more efficiently than previous methods (>48 h). Moreover, the CPI aerogel fabric demonstrates almost the same thermal insulating performance as down, but is about 1/8 the thickness of down. The strategy opens a promisingly wide-space for fast and scalable fabrication of ultrathin fabrics for personal thermal management.
Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort
Authors: Fukagawa Akihiko , Hama Natsuko , Totoki Yasushi , Nakamura Hiromi , Arai Yasuhito , Saito-Adachi Mihoko , Maeshima Akiko , Matsui Yoshiyuki , Yachida Shinichi , Ushiku Tetsuo , Shibata Tatsuhiro 
Published: December 2023

AbstractRenal cell carcinoma (RCC) comprises several histological types characterised by different genomic and epigenomic aberrations; however, the molecular pathogenesis of each type still requires further exploration. We perform whole-genome sequencing of 128 Japanese RCC cases of different histology to elucidate the significant somatic alterations and mutagenesis processes. We also perform transcriptomic and epigenomic sequencing to identify distinguishing features, including assay for transposase-accessible chromatin sequencing (ATAC-seq) and methyl sequencing. Genomic analysis reveals that the mutational signature differs among the histological types, suggesting that different carcinogenic factors drive each histology. From the ATAC-seq results, master transcription factors are identified for each histology. Furthermore, clear cell RCC is classified into three epi-subtypes, one of which expresses highly immune checkpoint molecules with frequent loss of chromosome 14q. These genomic and epigenomic features may lead to the development of effective therapeutic strategies for RCC.
Interaction of in-plane Drude carrier with c-axis phonon in PdCoO2
Authors: Seo Dongmin , Ahn Gihyeon , Rimal Gaurab , Khim Seunghyun , Chung Suk Bum , Mackenzie A. P. , Oh Seongshik , Moon S. J. , Choi Eunjip 
Published: December 2023

AbstractWe performed polarized reflection and transmission measurements on the layered conducting oxide PdCoO2thin films. For theab-plane, an optical peak near Ω ≈ 750 cm−1drives the scattering rate 1/τ(ω) and effective massm*(ω) of the Drude carrier to increase and decrease respectively forω ≧ Ω. For thec-axis, a longitudinal optical phonon (LO) is present at Ω as evidenced by a peak in the loss function Im[−1/εc(ω)]. Further polarized measurements in different light propagation (q) and electric field (E) configurations indicate that the Peak at Ω results from an electron-phonon coupling of theab-plane carrier with thec-LO phonon, which leads to the frequency-dependent 1/τ(ω) andm*(ω). This unusual interaction was previously reported in high-temperature superconductors (HTSC) between a non-Drude, mid-infrared (IR) band and ac-LO. On the contrary, it is the Drude carrier that couples in PdCoO2. The coupling between theab-plane Drude carrier andc-LO suggests that thec-LO phonon may play a significant role in the characteristicab-plane electronic properties of PdCoO2, including the ultra-high dc-conductivity, phonon-drag, and hydrodynamic electron transport.
Hall anomalies of the doped Mott insulator
Authors: Khait Ilia , Bhattacharyya Sauri , Samanta Abhisek , Auerbach Assa 
Published: December 2023

AbstractThe Hall coefficient of the strongly interacting square lattice Hubbard model is calculated for temperatures between the antiferromagnetic interaction and the Mott gap scales. The leading order thermodynamic formula is evaluated for all doping concentrations. Second-order corrections of the thermodynamic formula are calculated and found to be negligible. The Hall coefficient diverges toward the Mott insulator. Below 45% doping the Hall sign is reversed relative to band structure-based Boltzmann’s equation. These results elucidate the effects of the Mott insulator on the charge carriers and their non-Fermi liquid transport.
Learning and navigating digitally rendered haptic spatial layouts
Authors: Tivadar Ruxandra I. , Franceschiello Benedetta , Minier Astrid , Murray Micah M. 
Published: December 2023

AbstractLearning spatial layouts and navigating through them rely not simply on sight but rather on multisensory processes, including touch. Digital haptics based on ultrasounds are effective for creating and manipulating mental images of individual objects in sighted and visually impaired participants. Here, we tested if this extends to scenes and navigation within them. Using only tactile stimuli conveyed via ultrasonic feedback on a digital touchscreen (i.e., a digital interactive map), 25 sighted, blindfolded participants first learned the basic layout of an apartment based on digital haptics only and then one of two trajectories through it. While still blindfolded, participants successfully reconstructed the haptically learned 2D spaces and navigated these spaces. Digital haptics were thus an effective means to learn and translate, on the one hand, 2D images into 3D reconstructions of layouts and, on the other hand, navigate actions within real spaces. Digital haptics based on ultrasounds represent an alternative learning tool for complex scenes as well as for successful navigation in previously unfamiliar layouts, which can likely be further applied in the rehabilitation of spatial functions and mitigation of visual impairments.