bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term safety and efficacy of cipaglucosidase alfa plus miglustat in individuals living with Pompe disease: an open-label phase I/II study (ATB200-02)
Authors: Byrne Barry J. , Schoser Benedikt , Kishnani Priya S. , Bratkovic Drago , Clemens Paula R. , Goker-Alpan Ozlem , Ming Xue , Roberts Mark , Vorgerd Matthias , Sivakumar Kumaraswamy , van der Ploeg Ans T. , Goldman Mitchell , Wright Jacquelyn , Holdbrook Fred , Jain Vipul , Benjamin Elfrida R. , Johnson Franklin , Das Sheela Sitaraman , Wasfi Yasmine , Mozaffar Tahseen 
Published: December 2023

Abstract
Cipaglucosidase alfa plus miglustat (cipa + mig) is a novel, two-component therapy for Pompe disease. We report data from the Phase I/II ATB200-02 study for up to 48 months of treatment. Four adult cohorts, including one non-ambulatory ERT-experienced (n = 6) and three ambulatory cohorts, (two enzyme replacement therapy [ERT]-experienced cohorts [2–6 years (n = 11) and ≥ 7 years (n = 6)]), one ERT-naïve cohort (n = 6), received 20 mg/kg intravenous-infused cipa plus 260 mg oral mig biweekly. Change from baseline (CFBL) for multiple efficacy endpoints at 12, 24, 36, and 48 months, pharmacodynamics, pharmacokinetics, safety, and immunogenicity data were assessed. Six-minute walking distance (% predicted) improved at 12, 24, 36, and 48 months: pooled ambulatory ERT-experienced cohorts, mean(± standard deviation [SD]) CFBL: 6.1(± 7.84), n = 16; 5.4(± 10.56), n = 13; 3.4(± 14.66), n = 12; 5.9(± 17.36), n = 9, respectively; ERT-naïve cohort: 10.7(± 3.93), n = 6; 11.0(± 5.06), n = 6; 9.0(± 7.98), n = 5; 11.7(± 7.69), n = 4, respectively. Percent predicted forced vital capacity was generally stable in ERT-experienced cohorts, mean(± SD) CFBL − 1.2(± 5.95), n = 16; 1.0(± 7.96), n = 13; − 0.3(± 6.68), n = 10; 1.0(± 6.42), n = 6, respectively, and improved in the ERT-naïve cohort: 3.2(± 8.42), n = 6; 4.7(± 5.09), n = 6; 6.2(± 3.35), n = 5; 8.3(± 4.50), n = 4, respectively. Over 48 months, CK and Hex4 biomarkers improved in ambulatory cohorts. Overall, cipa + mig was well tolerated with a safety profile like alglucosidase alfa. ATB200-02 results show the potential benefits of cipa + mig as a long-term treatment option for Pompe disease. Trial registration number: NCT02675465 January 26, 2016.
The views of parents of children with cancer and pediatric physical therapists on a network for continuity and optimal quality of care for children with cancer: KinderOncoNet
Authors: Kleinlugtenbelt L. B. , Tissing W. J. E. , Solkema W. J. M. Plieger-van , van der Torre P. , Kollen W. J. W. , Gorter J. W. 
Published: December 2023

Abstract
Purpose
Children with cancer require specific therapeutic guidance. Parents prefer physical therapy close to home, while pediatric physical therapists (PPTs) working in the community may lack specific knowledge. The aim of this study is to determine the needs of parents of children with cancer and PPTs to inform the design and development of a care network, named “KinderOncoNet.”

Methods
We explored the perspectives and needs of parents of children with cancer and PPTs in the community, and we investigated the added value that KinderOncoNet could offer. We used an iterative process; data collection consisted of (1) gathering information from parents of children with cancer and PPTs through a survey and (2) co-creation sessions with stakeholders.

Results
In total, 98 parents and 177 PPTs participated in the survey. Parents (97%) and PPTs (93%) indicated that the care network would bring added value. All but one parent stressed the importance of a local PPT being aware of both the condition and the side and late effects of oncological treatment. Moreover, 40% of PPTs thought they do not have sufficient knowledge to provide high-quality therapy and that they would embrace opportunities for education. Through the co-creation sessions, a prototype of the care network was conceptualized.

Conclusion
KinderOncoNet can contribute to the continuity and quality of physiotherapy care for children with cancer during and after the oncological treatment. Such a network would allow for sharing knowledge, developing skills, and improving accessibility and communication in the Netherlands.
Exploring price tolerance in online retail: A comparative analysis of price comparison website use and repeat purchases
Authors: Berends Jan , Gerpott Torsten J. 
Published: December 2023

AbstractThe present empirical study is the first research to examine how the price tolerance of online buyers correlates with price comparison website (PCW) usage and customer relationship status (CRS). Longitudinal sales data of power tools and household appliances in 8,097 transactions from a German online shop and scraped PCW price data over a 6-months period in 2021 are used for the analysis. Consumer demand falls on average by around 80% per less favorable PCW rank. In addition, PCW (new) customers show significantly less price tolerance than organic (existing) customers. A small but significant interaction effect induces that the correlation of CRS and price tolerance is stronger for organic than for PCW customers.
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
Authors: Giotopoulou Nikolina , Shi Wenyang , Parniewska Malgorzata Maria , Sun Wenwen , Fuxe Jonas 
Published: December 2023

AbstractThe lymphatic system is a major gateway for tumor cell dissemination but the mechanisms of how tumor cells gain access to lymphatic vessels are not completely understood. Breast cancer cells undergoing epithelial-mesenchymal transition (EMT) gain invasive and migratory properties. Overexpression of the cytokine transforming growth factor β1 (TGFβ1), a potent inducer of EMT, is frequently detected in the tumor microenvironment and correlates with invasion and lymph metastasis. Recently, we reported that TGFβ1 stimulated breast cancer cells with mesenchymal properties to migrate in a targeted fashion towards the lymphatic system via CCR7/CCL21-mediated chemotaxis, similar to dendritic cells during inflammation. Here, we aimed to identify additional chemotactic factors and corresponding receptors that could be involved in guiding breast cancer cells through the lymphatic system. Through a combination of RNA sequencing analysis, database screening and invasion assays we identified IL7/IL7R and IL15/IL15R as pairs of chemokines and receptors with potential roles in promoting chemotactic migration of breast cancer cells with mesenchymal properties towards the lymphatics. The results demonstrate the capacity of TGFβ1 to orchestrate crosstalk between tumor cells and lymphatic endothelial cells and warrant further studies to explore the roles of IL7 and IL15 in promoting lymph metastasis of breast cancer.
Electronic Medication Reconciliation Tools Aimed at Healthcare Professionals to Support Medication Reconciliation: a Systematic Review
Authors: Ciudad-Gutiérrez Pablo , del Valle-Moreno Paula , Lora-Escobar Santiago José , Guisado-Gil Ana Belén , Alfaro-Lara Eva Rocío 
Published: December 2023

Abstract
The development of health information technology available and accessible to professionals is increasing in the last few years. However, a low number of electronic health tools included some kind of information about medication reconciliation. To identify all the electronic medication reconciliation tools aimed at healthcare professionals and summarize their main features, availability, and clinical impact on patient safety. A systematic review of studies that included a description of an electronic medication reconciliation tool (web-based or mobile app) aimed at healthcare professionals was conducted. The review protocol was registered with PROSPERO: registration number CRD42022366662, and followed PRISMA guidelines. The literature search was performed using four healthcare databases: PubMed, EMBASE, Cochrane Library, and Scopus with no language or publication date restrictions. We identified a total of 1227 articles, of which only 12 met the inclusion criteria.Through these articles,12 electronic tools were detected. Viewing and comparing different medication lists and grouping medications into multiple categories were some of the more recurring features of the tools. With respect to the clinical impact on patient safety, a reduction in adverse drug events or medication discrepancies was detected in up to four tools, but no significant differences in emergency room visits or hospital readmissions were found. 12 e-MedRec tools aimed at health professionals have been developed to date but none was designed as a mobile app. The main features that healthcare professionals requested to be included in e-MedRec tools were interoperability, “user-friendly” information, and integration with the ordering process.
Subjektive Fortbildungsbedarfe von Lehrkräften an Schulen in herausfordernden Lagen
Authors: Weber Kira Elena , Hawlitschek Patrick , Richter Dirk , Klusmann Uta 
Published: December 2023

ZusammenfassungDie Professionalisierung von Lehrkräften durch Fortbildungsmaßnahmen wird als eine zentrale Maßnahme zur Förderung von leistungsschwächeren Schülerinnen und Schülern benannt. Die Entscheidung darüber, welche Fortbildungen Lehrkräfte besuchen, hängt neben der Verfügbarkeit der Angebote auch von individuellen Faktoren wie dem Interesse und den akuten beruflichen Anforderungen der Lehrkräfte ab. Um eine möglichst hohe Passung zwischen den Bedarfen der Lehrkräfte und den Angeboten herzustellen, ist es wichtig, die Bedarfe von Lehrkräften zu kennen. Vor diesem Hintergrund geht die Arbeit der Frage nach, welche subjektiven Fortbildungsbedarfe Lehrkräfte an Schulen in herausfordernden Lagen haben, da diese Gruppe von Lehrkräften vor besonderen Anforderungen in Schule und Unterricht steht. Die vorliegende Studie beschreibt anhand einer Stichprobe von 2923 Lehrkräften aus 196 Schulen in herausfordernden Lagen, in welchen fachübergreifenden Kompetenzbereichen Lehrkräfte einen Fortbildungsbedarf angeben. Darüber hinaus untersucht sie, welche sozio-demographischen und motivational-emotionalen Merkmale die fachübergreifenden Fortbildungsbedarfe vorhersagen können. Die Ergebnisse aus latenten Strukturgleichungsmodellen zeigen, dass Lehrkräfte einen erhöhten Fortbildungsbedarf im Bereich Lernförderung und Digitaler Medieneinsatz sehen. Die Befunde aus offenen Antworten ergänzen diesen Bedarf um die Themen Umgang mit sonderpädagogischem Förderbedarf und Umgang mit Heterogenität. Zudem zeigen die Analysen, dass sowohl sozio-demographische Merkmale (Geschlecht, Berufserfahrung und Quer- und Seiteneinstieg) als auch motivational-emotionale Lehrkraftmerkmale (subjektive Kompetenzeinschätzungen, emotionale Erschöpfung und Attributionen von Schülerinnen- und Schülerleistung) relevante Prädiktoren für spezifische, fachübergreifende Fortbildungsbedarfe darstellen. Die Arbeit diskutiert mögliche Konsequenzen für das Angebot von Fortbildungsmaßnahmen.
Sustainability of international research: evidence from an H2020 European project
Authors: Fabiani Claudia , Frota de Albuquerque Landi Fabiana , Cabeza Luisa F. , Pisello Anna Laura 
Published: December 2023

AbstractGreenhouse gas emissions reduction is a critical topic in the scientific community, as researchers strive to produce knowledge for the betterment of society. However, it is important to acknowledge that researchers themselves engage in activities that have a significant environmental impact. Group meetings and conferences are under the spot due to their extensive contribution to emissions through travel, catering, hosting, and other event-related activities. To address this issue, our work aims to conduct an environmental diagnosis of an ongoing H2020 European project, focusing on the impacts associated with the periodical group meetings organized in each country involved. We also sought to evaluate researchers’ stance on online meetings and collected environmental and personal opinions through dedicated online forms. Results show that while travel is the primary contributor to emissions, catering, meeting structures, and hosting support should not be overlooked. Conference location and availability of public transportation also play a crucial role in the final impact of the event, as they affect directly the 87% share of emissions due to travels. Besides, using local distributors and reducing hotel stays (representing about 5% of the final impact) may reduce the potential environmental burden of these events. On the other side, besides the obtained positive feedback from online meetings, in-person activities are still more effective for reinforcing human bonds and collaborations.
Generative artificial intelligence
Authors: Banh Leonardo , Strobel Gero 
Published: December 2023

AbstractRecent developments in the field of artificial intelligence (AI) have enabled new paradigms of machine processing, shifting from data-driven, discriminative AI tasks toward sophisticated, creative tasks through generative AI. Leveraging deep generative models, generative AI is capable of producing novel and realistic content across a broad spectrum (e.g., texts, images, or programming code) for various domains based on basic user prompts. In this article, we offer a comprehensive overview of the fundamentals of generative AI with its underpinning concepts and prospects. We provide a conceptual introduction to relevant terms and techniques, outline the inherent properties that constitute generative AI, and elaborate on the potentials and challenges. We underline the necessity for researchers and practitioners to comprehend the distinctive characteristics of generative artificial intelligence in order to harness its potential while mitigating its risks and to contribute to a principal understanding.
Ultrastructural, Secondary Metabolite, and Antioxidant Modulation in Response to Salt-Affected Habitats Induced Oxidative Stress and Their Accumulation in Malva parviflora L. and Rumex dentatus L.
Authors: Kazamel Amany M. , Haroun Samia A. , Noureldin Alshaymaa A. , El-Sherbiny Ghada A. , El-Shahaby Omer A. , Sofy Mahmoud R. , AlBakry Alaa F. , Gamel Rasha M. E. 
Published: December 2023

AbstractSalinity stress is a major abiotic factor that affects medicinal plant growth, performance, and secondary compounds. Malva parviflora L. and Rumex dentatus L. plants were collected from three habitats in the northeastern Nile Delta governorates of Damietta and El-Dakahlia. Conductivity (salinity) classified the habitats as mesophytic, moderately saline, and saline. Chemical and physical soil characteristics varied by habitat. Results show that M. parviflora L. and R. dentatus L. had high soluble sugars, total carbohydrates, electrolyte leakage, and proline in the saline habitat. In contrast, mesophytic habitats showed low content. In addition, R. dentatus L. had more antioxidant enzymes and elements in saline habitats than in mesophytic habitats. In saline habitats, M. parviflora L. and R. dentatus L. were characterized by more calcium and sodium increase than mesophytic habitats. Moreover, R. dentatus L. had more phenols, alkaloids, flavonoids, anthocyanin, and tannins under saline conditions than M. parviflora. Meanwhile, in the saline habitat, plant hormones, i.e., indole acetic acid and gibberellic acid, decreased significantly in both M. parviflora and R. dentatus than in the mesophytic habitat. Scanning Electron Microscopy (SEM) of the tested plants showed the highest stomatal frequency and area on the lower surface of mesophytic plant leaves compared to either its upper surface or both leaf surfaces in saline habitat. Hence, it can be concluded that R. dentatus plant can mitigate the negative effects of salinity by improving the qualitative and quantitative performance under salinity stress more than M. parviflora plant.
Update of the year 2019 modeling emission inventory in China
Authors: Kim Seoyeon , Kim Jinseok , Hu Hyejung , Jang Meongdo , Lee Jae-Bum , Hong Sung Chul , Kim Okgil , Woo Jung-Hun 
Published: December 2023

AbstractUsing updated emission inventories can enhance the accuracy of air quality forecast models. Given China’s rapid economic growth and Korea’s geographical and meteorological position on the windward side of China, updating China’s emission inventory has become particularly crucial for Korea’s air quality modeling. This study aimed to develop an updated version of China’s Emission Inventory in Comprehensive Regional Emissions for Atmospheric Transport Experiments version 3 for the base year of 2019 (CREATEv3 (YR 2019)). To achieve this goal, we utilized the Chinese emission inventory of CREATEv3 for the base year of 2015 (CREATEv3 (YR 2015)) as a framework to incorporate the latest Chinese emission data from the Multi-resolution Emission Inventory Model for Climate and Air Pollution Research for the base year of 2019 (MEIC COVID-19 (YR 2019)) and update the inventory. The updated China’s annual emissions are now reflected in CREATEv3 (YR 2019), and the amounts are as follows: 132 Tg for CO, 21 Tg for NOx, 8 Tg for SO2, 7 Tg for PM2.5, 9 Tg for NH3, and 28 Tg for volatile organic compound (VOC). By comparing previous Chinese emission inventories with the updated inventory developed in this study, it was found that SO2, NOx, VOC, and NH3 emissions were decreased. Therefore, using the updated inventory seemingly reduces the impact of China’s fine dust on Korea. By comparing emissions by pollutant and region in China using CREATEv3 (YR 2019), it was found that regions with high emissions of targeted pollutants strongly correlated with major industries operating in those areas. This study is expected to provide insights into China’s emission changes in 2019 and support air quality forecasting.
Association Between Stroke Severity and Serum Troponin in Acute Stroke
Authors: Kuczynski Andrea M. , Rzyczniak Grace , Cheong Gee Hung Leo , Famiyeh Petra , Vyas Manav V. 
Published: December 2023

ABSTRACT:Serum troponin is often elevated in patients with acute stroke and its mechanism is unknown. In a retrospective single-center cohort study, we evaluated the association between stroke severity and serum troponin in 187 patients with acute stroke using multivariable modified Poisson models. A one-point increase in the National Institutes of Health Stroke Scale (measure of stroke severity) was associated with a marginally higher serum troponin level in adjusted models (aIRR 1.03; 1.01–1.05, P = 0.001). The modest, yet potentially independent, association between stroke severity and serum troponins could suggest a neurogenic basis for a cardiac injury in patients with acute stroke.
DIVIDING LINES BETWEEN POSITIVE THEORIES
Authors: DMITRIEVA ANNA , GALLINARO FRANCESCO , KAMSMA MARK 
Published: December 2023

AbstractWe generalise the properties$\mathsf {OP}$,$\mathsf {IP}$,k-$\mathsf {TP}$,$\mathsf {TP}_{1}$,k-$\mathsf {TP}_{2}$,$\mathsf {SOP}_{1}$,$\mathsf {SOP}_{2}$, and$\mathsf {SOP}_{3}$to positive logic, and prove various implications and equivalences between them. We also provide a characterisation of stability in positive logic in analogy with the one in full first-order logic, both on the level of formulas and on the level of theories. For simple theories there are the classically equivalent definitions of not having$\mathsf {TP}$and dividing having local character, which we prove to be equivalent in positive logic as well. Finally, we show that a thick theoryThas$\mathsf {OP}$iff it has$\mathsf {IP}$or$\mathsf {SOP}_{1}$and thatThas$\mathsf {TP}$iff it has$\mathsf {SOP}_{1}$or$\mathsf {TP}_{2}$, analogous to the well-known results in full first-order logic where$\mathsf {SOP}_{1}$is replaced by$\mathsf {SOP}$in the former and by$\mathsf {TP}_{1}$in the latter. Our proofs of these final two theorems are new and make use of Kim-independence.
Beyond the limitations of any imaginable mechanism: Large language models and psycholinguistics
Authors: Houghton Conor , Kazanina Nina , Sukumaran Priyanka 
Published: December 2023

Abstract
Large language models (LLMs) are not detailed models of human linguistic processing. They are, however, extremely successful at their primary task: Providing a model for language. For this reason LLMs are important in psycholinguistics: They are useful as a practical tool, as an illustrative comparative, and philosophically, as a basis for recasting the relationship between language and thought.
Psychophysics may be the game-changer for deep neural networks (DNNs) to imitate the human vision
Authors: Chandran Keerthi S. , Paul Amrita Mukherjee , Paul Avijit , Ghosh Kuntal 
Published: December 2023

Abstract
Psychologically faithful deep neural networks (DNNs) could be constructed by training with psychophysics data. Moreover, conventional DNNs are mostly monocular vision based, whereas the human brain relies mainly on binocular vision. DNNs developed as smaller vision agent networks associated with fundamental and less intelligent visual activities, can be combined to simulate more intelligent visual activities done by the biological brain.
OffensEval 2023: Offensive language identification in the age of Large Language Models
Authors: Zampieri Marcos , Rosenthal Sara , Nakov Preslav , Dmonte Alphaeus , Ranasinghe Tharindu 
Published: December 2023

AbstractThe OffensEval shared tasks organized as part of SemEval-2019–2020 were very popular, attracting over 1300 participating teams. The two editions of the shared task helped advance the state of the art in offensive language identification by providing the community with benchmark datasets in Arabic, Danish, English, Greek, and Turkish. The datasets were annotated using the OLID hierarchical taxonomy, which since then has become the de facto standard in general offensive language identification research and was widely used beyond OffensEval. We present a survey of OffensEval and related competitions, and we discuss the main lessons learned. We further evaluate the performance of Large Language Models (LLMs), which have recently revolutionalized the field of Natural Language Processing. We use zero-shot prompting with six popular LLMs and zero-shot learning with two task-specific fine-tuned BERT models, and we compare the results against those of the top-performing teams at the OffensEval competitions. Our results show that while some LMMs such as Flan-T5 achieve competitive performance, in general LLMs lag behind the best OffensEval systems.
The Onset of Recrystallization in Polar Firn
Authors: Ogunmolasuyi Ayobami , Murdza Andrii , Baker Ian 
Published: December 2023

AbstractConstraining the onset of dynamic recrystallization (DRX) and its effects on the mechanical properties of firn is crucial for firn densification modeling. To that end, samples from a depth of 13 m in a Summit, Greenland (72°35′N, 38°25′W) firn core were subjected to creep tests at −14°C and 0.21 MPa compressive stress to strains of 7%, 12%, 18%, and 29%. Microstructural analyses using thin‐section imaging and microcomputed x‐ray tomography (micro‐CT) revealed smaller grain sizes, reduced specific surface area and connectivity, and increased density in relation to reduced porosity as the strain increases. These results show that DRX occurs in firn under creep, with strain‐induced boundary migration (SIBM) and nucleation and growth starting at ∼7%. DRX leads to elongated grains, reduced grain size, and the development of a preferred crystallographic orientation, indicating that DRX occurs by both SIBM and nucleation and growth.