bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical application of two-port laparoscopic surgery in sigmoid colon and upper rectal cancer resection
Authors: Jiang Feng , Ji Mengmeng , Jin Fangtong , Liu Junfeng , Liu Xiaoping 
Published: November 2023

BackgroundIn the field of minimally invasive surgery, the two-port laparoscopic surgery is on the rise. This study investigated the safety and efficacy of two-port laparoscopic surgery (TLS) for resecting sigmoid colon and upper rectal cancers compared with conventional laparoscopic surgery (CLS).MethodsThe clinical data of patients undergoing laparoscopic sigmoid colon cancer and upper rectal cancer resection at the Department of General Surgery of the First Affiliated Hospital of Gannan Medical College between July 2019 and January 2022 were retrospectively collected. Grouped according to different laparoscopic surgery. Based on the inclusion and exclusion criteria,A total of 81 patients were enrolled, of the 25 patients from the TLS group,and of the 56 patients from the CLS group. We mainly compared whether there were statistical differences between the two groups in terms of operative time, intraoperative bleeding, incision length, time to first ambulation, time to first flatus, time to first defecation, postoperative complication rate, and other surgical outcomes.ResultsThere was no statistical difference between the two groups in terms of baseline clinical characteristics (P &gt; 0.05). In terms of the surgical outcomes, there were statistical differences in the total incision length (TLS: 6.21 ± 0.67 cm, CLS: 8.64 ± 1.08 cm, P &lt; 0.001)), time to first ambulation (TLS: 2.0 ± 0.7 d, CLS:3.1 ± 0.9 d, P &lt; 0.001), time to first flatus (TLS: 2.5 ± 0.8 d, CLS: 3.0 ± 0.8 d, P = 0.028), time to first defecation (TLS: 3.8 ± 1.3 d, CLS: 5.1 ± 2.1 d, P = 0.010), and time for liquid diet (TLS: 4.3 ± 1.4 d, CLS: 5.3 ± 1.9 d, P = 0.021). There was no statistical difference between the two groups in terms of the pathology (P &gt; 0.05).ConclusionIn terms of safety, TLS in sigmoid colon and upper rectal cancer resection is comparable to CLS. However, its incision is smaller and more aesthetic, and it causes lesser trauma than CLS. Additionally, it is also superior to CLS in postoperative recovery.
Intranasal dexmedetomidine vs. oral midazolam for premedication in children: a systematic review and meta-analysis
Authors: Zhang Guangxuan , Xin Li , Yin Qingtang 
Published: November 2023

ObjectiveTo compare the effects of intranasal dexmedetomidine (Dex) and oral midazolam in the preoperative medication of children by using a method of meta-analysis.MethodsCochrane Library, Pubmed, Embase, and Web of Science were searched from inception to July 2023. Randomized controlled trials (RCTs) of intranasal Dex vs. oral midazolam in pediatric premedication were collected. Stata 15.0 statistical software was used to analyze the collected data. Relative risk (RR) and 95% confidence interval (CI) were used as effect sizes.ResultsA total of 11 studies with 824 children were included, containing 415 patients in the Dex group and 409 patients in the midazolam group. Compared with the oral midazolam group, the intranasal Dex group had a better preoperative sedation effect at parent-child separation (RR = 1.37, 95% CI: 1.14–1.64) and anesthesia induction (RR = 2.08, 95% CI: 1.03–4.22). In addition, there was no significant difference in the incidence of analgesia remedy (RR = 0.60, 95% CI: 0.36–1.00) the acceptance of anesthesia masks (RR = 0.97, 95% CI: 0.83–1.12), and incidence of adverse events between (RR = 0.25, 95% CI: 0.06–1.13, P = 0.072) between the intranasal Dex and oral midazolam groups.ConclusionCompared with oral midazolam, intranasal Dex has better sedative effects of parent-child separation and anesthesia induction in pediatric premedication, but there was no difference in the incidence of anesthesia remedy, anesthesia mask acceptance, and incidence of adverse events. Therefore, compared with oral midazolam, intranasal Dex is a better choice for premedication in children.
Antihypertensive medications and risk of colorectal cancer in British Columbia
Authors: Qi Jia , Bhatti Parveen , Spinelli John J. , Murphy Rachel A. 
Published: November 2023

Introduction: There is conflicting evidence for the association between antihypertensive medications and colorectal cancer risk, possibly reflecting methodological limitations of previously conducted studies. Here, we aimed to clarify associations between commonly prescribed antihypertensive medication classes and colorectal cancer risk in a large, retrospective, cohort study.Methods: Using linked administrative data between 1996 and 2017 from British Columbia, we identified a cohort of 1,693,297 men and women who were 50 years of age or older, initially cancer-free and nonusers of antihypertensive medications. Medication use was parameterized as ever use, cumulative duration, and cumulative dose. Cox proportional hazard models were used to estimate hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) for associations of time-varying medication use [angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), beta-blockers (BBs), calcium channel blockers (CCBs), and diuretics] with colorectal cancer risk.Results: There were 28,460 incident cases of colorectal cancer identified over the follow-up period (mean = 12.9 years). When medication use was assessed as ever/never, diuretics were associated with increased risk of colorectal cancer (HR 1.08, 95% CI 1.04–1.12). However, no similar association was observed with cumulative duration or cumulative dose of diuretics. No significant associations between the other four classes of medications and colorectal cancer risk were observed.Conclusion: No compelling evidence of associations between antihypertensive medications and colorectal cancer were observed.
Molecular mechanisms underpinning quantitative resistance to Phytophthora sojae in Glycine max using a systems genomics approach
Authors: Million Cassidy R. , Wijeratne Saranga , Karhoff Stephanie , Cassone Bryan J. , McHale Leah K. , Dorrance Anne E. 
Published: November 2023

Expression of quantitative disease resistance in many host–pathogen systems is controlled by genes at multiple loci, each contributing a small effect to the overall response. We used a systems genomics approach to study the molecular underpinnings of quantitative disease resistance in the soybean-Phytophthora sojae pathosystem, incorporating expression quantitative trait loci (eQTL) mapping and gene co-expression network analysis to identify the genes putatively regulating transcriptional changes in response to inoculation. These findings were compared to previously mapped phenotypic (phQTL) to identify the molecular mechanisms contributing to the expression of this resistance. A subset of 93 recombinant inbred lines (RILs) from a Conrad × Sloan population were inoculated with P. sojae isolate 1.S.1.1 using the tray-test method; RNA was extracted, sequenced, and the normalized read counts were genetically mapped from tissue collected at the inoculation site 24 h after inoculation from both mock and inoculated samples. In total, more than 100,000 eQTLs were mapped. There was a switch from predominantly cis-eQTLs in the mock treatment to an almost entirely nonoverlapping set of predominantly trans-eQTLs in the inoculated treatment, where greater than 100-fold more eQTLs were mapped relative to mock, indicating vast transcriptional reprogramming due to P. sojae infection occurred. The eQTLs were organized into 36 hotspots, with the four largest hotspots from the inoculated treatment corresponding to more than 70% of the eQTLs, each enriched for genes within plant–pathogen interaction pathways. Genetic regulation of trans-eQTLs in response to the pathogen was predicted to occur through transcription factors and signaling molecules involved in plant–pathogen interactions, plant hormone signal transduction, and MAPK pathways. Network analysis identified three co-expression modules that were correlated with susceptibility to P. sojae and associated with three eQTL hotspots. Among the eQTLs co-localized with phQTLs, two cis-eQTLs with putative functions in the regulation of root architecture or jasmonic acid, as well as the putative master regulators of an eQTL hotspot nearby a phQTL, represent candidates potentially underpinning the molecular control of these phQTLs for resistance.
Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia
Authors: Pelegrino Ana , Guimaraes Anna Luiza , Sena Walter , Emele Nwabunwanne , Scoriels Linda , Panizzutti Rogerio 
Published: November 2023

IntroductionThe locus coeruleus-noradrenaline (LC-NA) system is involved in a wide range of cognitive functions and may be altered in schizophrenia. A non-invasive method to indirectly measure LC activity is task-evoked pupillary response. Individuals with schizophrenia present reduced pupil dilation compared to healthy subjects, particularly when task demand increases. However, the extent to which alteration in LC activity contributes to schizophrenia symptomatology remains largely unexplored. We aimed to investigate the association between symptomatology, cognition, and noradrenergic response in individuals with schizophrenia.MethodsWe assessed task-evoked pupil dilation during a pro- and antisaccade task in 23 individuals with schizophrenia and 28 healthy subjects.ResultsBoth groups showed similar preparatory pupil dilation during prosaccade trials, but individuals with schizophrenia showed significantly lower pupil dilation compared to healthy subjects in antisaccade trials. Importantly, reduced preparatory pupil dilation for antisaccade trials was associated with worse general symptomatology in individuals with schizophrenia.DiscussionOur findings suggest that changes in LC-NA activity – measured by task-evoked pupil dilation – when task demand increases is associated with schizophrenia symptoms. Interventions targeting the modulation of noradrenergic responses may be suitable candidates to reduce schizophrenia symptomatology.
Severity identification for internet gaming disorder using heart rate variability reactivity for gaming cues: a deep learning approach
Authors: Hong Sung Jun , Lee Deokjong , Park Jinsick , Kim Taekyung , Jung Young-Chul , Shon Young-Min , Kim In Young 
Published: November 2023

BackgroundThe diminished executive control along with cue-reactivity has been suggested to play an important role in addiction. Hear rate variability (HRV), which is related to the autonomic nervous system, is a useful biomarker that can reflect cognitive-emotional responses to stimuli. In this study, Internet gaming disorder (IGD) subjects’ autonomic response to gaming-related cues was evaluated by measuring HRV changes in exposure to gaming situation. We investigated whether this HRV reactivity can significantly classify the categorical classification according to the severity of IGD.MethodsThe present study included 70 subjects and classified them into 4 classes (normal, mild, moderate and severe) according to their IGD severity. We measured HRV for 5 min after the start of their preferred Internet game to reflect the autonomic response upon exposure to gaming. The neural parameters of deep learning model were trained using time-frequency parameters of HRV. Using the Class Activation Mapping (CAM) algorithm, we analyzed whether the deep learning model could predict the severity classification of IGD and which areas of the time-frequency series were mainly involved.ResultsThe trained deep learning model showed an accuracy of 95.10% and F-1 scores of 0.995 (normal), 0.994 (mild), 0.995 (moderate), and 0.999 (severe) for the four classes of IGD severity classification. As a result of checking the input of the deep learning model using the CAM algorithm, the high frequency (HF)-HRV was related to the severity classification of IGD. In the case of severe IGD, low frequency (LF)-HRV as well as HF-HRV were identified as regions of interest in the deep learning model.ConclusionIn a deep learning model using the time-frequency HRV data, a significant predictor of IGD severity classification was parasympathetic tone reactivity when exposed to gaming situations. The reactivity of the sympathetic tone for the gaming situation could predict only the severe group of IGD. This study suggests that the autonomic response to the game-related cues can reflect the addiction status to the game.
The impact of DRG on resource consumption of inpatient with ischemic stroke
Authors: Wei Anle , Ren Jianing , Feng Wen 
Published: November 2023

BackgroundDiagnosis-related group (DRG) payments were gradually introduced and used in 12 public hospitals in L city. Given the high incidence and burden of ischemic stroke, the study aimed to assess the impact of DRG payment reform on inpatient medical resource utilization.MethodsData were obtained from the DRG local database of the new Chinese cooperative medical program in L city. The study used interrupted time series analysis to examine changes in length of stay and medical costs before and after the reform, and also assessed changes in different subgroups.ResultsThere were 763 and 4,731 ischemic stroke patients in tertiary hospitals and 1953 and 10,439 patients in secondary hospitals before and after the DRG payment reform, respectively. After the reform, LOS was reduced 0.047 and 0.47 days in tertiary and secondary hospitals, respectively. Medical expenses decreased by 30.189 yuan in tertiary hospitals, but those increased by 44.918 yuan in secondary hospitals monthly. For gender, the average LOS reduced by 0.462 and 0.471 days for male and female in secondary hospitals. The change in medical expenses for male patients in tertiary hospitals and female in secondary hospitals were more significant, with a decrease of 65.396 yuan and increase of 56.257 yuan. The most pronounced change in resource consumption was seen for patients aged 85 years and older, with an increase in average LOS and medical expenses by 0.394 days and 382.422 yuan in tertiary hospitals. They showed a reduction in the average LOS by 1.480 days, and increase in the average medical expenses by 133.485 yuan in secondary hospitals monthly. Regarding disease severity, the most significant changes were seen in MCC patients. The average LOS decreased by 0.197 and 0.928 days and the average medical expenses decreased by 131.526 and 21.631 yuan in tertiary and secondary hospitals, respectively.ConclusionThe implementation of DRG payment system has led to a reduction in the LOS in various levels of hospitals, which would save in bed resources. However, DRG payment reform can help to control medical expenses for ultra-high cases, but it may not be useful to control the overall increase in medical expenses.
Reduced abundance of Faecalibacterium prausnitzii in the gut microbiota of children diagnosed with cancer, a pilot study
Authors: de Muinck Eric J. , Trosvik Pål , Nguyen Nga , Fashing Peter J. , Stigum Vetle M. , Robinson Nina , Hermansen Johanne U. , Munthe-Kaas Monica C. , Baumbusch Lars O. 
Published: November 2023

BackgroundThere is an increasing awareness of the importance of the gut microbiome in disease progression and the maintenance of human health. However, links between the microbiome and cancer onset remain relatively unexplored. This is especially the case for childhood cancers, which although rare, are the predominant cause of death among children in Western countries.MethodsFecal samples were collected from patients, before the onset of treatment, by the Norwegian Childhood Cancer Biobank in Oslo and from children attending kindergartens in Oslo, Norway. Using 16S rRNA gene amplicon sequencing, we compared the gut microbiome compositions of the children diagnosed with cancer with children attending kindergarten.ResultsWe observed significant differences in the relative abundances of several taxa, including a striking depletion of Faecalibacterium prausnitzii, an important taxa linked to gut health maintenance.ConclusionsOur observations provide evidence that the gut microbiome may play an important role in physiological changes associated with the onset of childhood cancer. However, further studies should be designed in order to validate our findings. Furthermore, these results suggest that variations in the microbial community could potentially be used as an early indicator of childhood cancer.
Evaluating cognitive performance using virtual reality gamified exercises
Authors: Borghetti Davide , Zanobini Carlotta , Natola Ilenia , Ottino Saverio , Parenti Angela , Brugada-Ramentol Victòria , Jalali Hossein , Bozorgzadeh Amir 
Published: November 2023

Virtual Reality (VR) environments have been proven useful in memory assessment and have shown to be more sensitive than pen-and-paper in prospective memory assessment. Moreover, these techniques provide the advantage of offering neuropsychological evaluations in a controlled, ecologically valid, and safe manner. In the present study, we used Enhance VR, a cognitive training and assessment tool in virtual reality. User performance was evaluated by means of the in-game scoring system. The primary goal of this study was to compare Enhance VR in-game scoring to already existing validated cognitive assessment tests. As a secondary goal, we tested the tolerance and usability of the system. 41 older adults took part in the study (mean age = 62.8 years). Each participant was evaluated with a predefined set of traditional pen-and-paper cognitive assessment tools and played four VR games. We failed to find a significant positive impact in explaining the variability of the Enhance VR game scores by the traditional pen-and-paper methodologies that addressed the same cognitive ability. This lack of effect may be related to the gamified environment of Enhance VR, where the players are awarded or subtracted points depending on their game performance, thus deviating from the scoring system used in traditional methodologies. Moreover, while the games were inspired by traditional assessment methodologies, presenting them in a VR environment might modify the processing of the information provided to the participant. The hardware and Enhance VR games were extremely well tolerated, intuitive, and within the reach of even those with no experience.
Pengenalan Pola Serangan pada Internet of Thing (IoT) Menggunakan Support Vector Mechine (SVM) dengan Tiga Kernel
Authors: Tasmi Tasmi , Antony Ferry , Dhamyanti Dhamyanti , Setiawan Herri , Oklilas Fali 
Published: November 2023

Internet of things (IoT) teknologi yang sangat populer akhir-akhir ini di seluruh dunia, Dengan berkembangnya teknologi IoT ini memunculkan dampak ancaman keamanan dan serangan terhadap perangkat IoT. Salah satu yang paling banyak adalah pencurian data dan informasi, salah satu bentuk ancaman dalam IoT adalah malware. Dalam penelitian ini menggunakan serangan dalam bentuk bontet untuk mendeteksi serangan pada Internet of Things IoT) dan menggunakan Machine Learning untuk melakukan deteksi data terhadap serangan pada perangkat IoT. Metode yang digunakan dalam peneltian ini adalah Support Vector Mechine (SVM) dengan membandingkan tiga kernel yaitu Liner, polynominal dan Radial Basis Function (RBF). Metode ini digunakan untuk mengetahui tingkat akurasi pada proses deteksi dan melakukan pebandingan antara kernel. Hasil yang didapatkan nilai akurasinya 0.997 untuk kernel liner artinya kernel ini mampu dengan baik untuk memisahkan kelas dengan baik, sedangan kernel Polynomial nilai akurasinya sebesar 0.993 ini hasilnya baik dalam memisahkan kelas walaupun nilai lebih kecil dari liner. Sedangkan Kernel RBF (Radial Basis Function) memiliki akurasi sebesar 1.0 (100%)
GAMBARAN PENGETAHUAN IBU NIFAS TENTANG PERAWATAN LUKA PERINEUM (LITERATURE REVIEW)
Authors: Sakti Bani , Ramadhiany Ayu Aulia , Kusniasih Susi 
Published: November 2023

ABSTRAK

Penelitian ini dilatarbelakangi oleh angka kematian ibu di Indonesia masih tinggi sebesar 339/100.000 KH. Angka kematian ibu di Indonesia masih didominasi oleh perdarahan (42%), eklampsia/preeklampsia (13%), abortus (11%), infeksi (10%), partus lama/persalinan macet (9%). Infeksi masa nifas masih berperan sebagai penyebab kematian ibu terutama di Indonesia, infeksi tersebut mencakup semua peradangan yang disebabkan oleh masuknya kuman-kuman kedalam alat genital pada waktu persalinan dan nifas yang terjadi pada perineum bisa terjadi di vu lva, vagina, serviks dan endometrium. Pada ibu primigravida maupun multigravida ssat persalinan sering mengalami robekan pada jalan lahir dan perlu pengetahuan yang luas terhadap perawatan

luka perineum. Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan ibu nifas tentang perawatan luka perineum. Jenis Penelitian yang digunakan adalah deskriptif dengan desai penelitian literature review, yaitu merujuk pada riset yang berfokus pada topik tertentu. Data yang digunakan dalam penelitian ini adalah data sekunder berupa buku atau artikel yang dicari melalui situs pencarian seperti google scholar, PubMed, atau Portal garuda dengan kata kunci pengetahuan, ibu nifas, perawatan luka perineum. Hasil penelitian menunjukkan bahwa pada jurnal 1 pengetahuan ibu nifas tentang perawatan luka perineum baik sebesar (97,5%) 39 orang, jurnal 2 pengetahuan cukup sebesar (53,3%) 16 orang, dan jurnal 3 pengetahuan baik sebesar (54%) 27 orang. Dapat disimpulkan sebagian besar ibu nifas sudah mengetahui tentang perawatan luka perineum. Pengetahuan dikatakan kurang karena belum mengetahui perawatan luka perineum, tanda bahaya selama nifas dan kebutuhan perawatan luka untuk penyembuhan luka. Direkomendasikan kepada profesi keperawatan untuk memberikan pendidikan kesehatan dalam meningkatkan pengetahuan ibu nifas tentang perawatan luka perineum.

Kata Kunci : Pengetahuan, Ibu nifas, Perawatan luka perineum
PEMBERDAYAAN KELUARGA MELALUI PENDAMPINGAN IBU HAMIL BERBASIS LOVES BUMIL (LOGBOOK TO PREVENT STUNTING) MELALUI SWAP (SHARING VIA WHATSAPP)
Authors: Astuti Maya Astuti 
Published: November 2023

Angka kejadian stunting di Kabupaten Bogor tahun 2020 yaitu 12,69% kasus dan menurun ditahun 2021 menjadi 9,89% kasus. Stunting adalah masalah kurang gizi kronis dalam jangka waktu yang lama. Salah satu penyebab tidak langsung stunting adalah rendahnya pengetahuan ibu tentang pola asuh dan nutrisi. Dibutuhkan media untuk membantu meningkatkan pengetahuan ibu sekaligus menjadi media kontrol tentang asuhan yang sudah dan belum dilakukan. Agenda Ibu Hamil yang disebut Logbook system to prevent stunting (LOVES BUMIL) adalah sebuah buku yang dirancang menjadi dokumen penting untuk mencatat setiap asuhan dalam mencegah stunting. Tujuan kegiatan IbM adalah menurunkan faktor risiko stunting melalui kegiatan pendampingan ibu hamil via kelas online berbasis LOVES BUMIL. Metode pengabdian masyarakat dilakukan dengan melibatkan 2 mitra yaitu RW.2 dan RW.3 Kelurahan Bojong, dengan jumlah mitra sebanyak 20 orang ibu hamil trimester 1-3. Terdiri dari 7 kegiatan untuk masing-masing mitra yang diawali dengan pretest, sosialisasi LOVES BUMIL dan pemberian materi melalui metode sharing via whatsapp (SWAP). Evaluasi kepada mitra dilakukan dengan post test dan penilaian asuhan yang sudah mitra dapatkan. Hasil, terdapat peningkatan rata-rata pengetahuan pada kedua kelompok mitra. Mitra 1 meningkat dari 71.28 menjadi 89.4 dan mitra 2 dari 64.35 menjadi 82.4. Dari segi asuhan kehamilan, semua mitra telah mendapatkan asuhan yang tepat sesuai kebutuhannya. Saran, kegiatan pendampingan ibu hamil berbasis logbook sistem to prevent stunting ini dapat dilakukan secara terus menerus didaerah lain.