bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial screening instruments to assist support consultants in patients with cancer
Authors: Driessen Helen Pieternel Antonie , van der Rijt Carin C D , Busschbach Jan J V , Elfrink Erna J , Kranenburg Leonieke W 
Published: January 2024

ObjectivesAround 30% of patients with cancer suffer from psychosocial problems requiring formal care; however, these problems are often not identified. Support consultants may play a role in identifying these problems. This study investigates the feasibility of using validated screening instruments to assist support consultants in identifying psychosocial problems.MethodsProspective observational study focusing on patients visiting support consultants at hospital-affiliated centres for information and support. The feasibility of using screening instruments was assessed based on the percentage of patients willing to participate. For these patients, possible psychosocial problems were objectified, and referral to formal care was assessed.ResultsOut of 227 eligible patients at IntermeZZo, 48 participated (21.1%). At PATIO, over 141 consultations took place and 27 patients participated. Main reason for non-participation was that patients did not feel such a need. The majority showed elevated scores, indicating possible psychosocial problems and around half were referred. Respecting the individual needs of patients and offering them with what benefits them is crucial, including screening instruments does not match their needs nor did support consultants feel it was appropriate in certain cases.ConclusionGiven the low percentage of questionnaires administered, it does not seem feasible to systematically administer them to patients visiting support consultants.
Expanding single-trace YMS amplitudes with gauge-invariant coefficients
Authors: Wei Fang-Stars , Zhou Kang 
Published: January 2024

AbstractIn this note, we use the new bottom-up method based on soft theorems to recursively construct the expansion of single-trace Yang–Mills-scalar amplitudes. The resulting expansion manifests the gauge invariance for any polarization carried by external gluons, as well as the permutation symmetry among external gluons. Our result is equivalent to that found by Clifford Cheung and James Mangan via the so-called covariant color–kinematics duality approach.
DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance
Authors: Wang Hui , Zhang Yanyang , Tian Yu , Yang Wanlin , Wang Yan , Hou Hui , Pan Hanbo , Pei Siyu , Zhu Hongda , Gu Zenan , Zhang Yanyun , Dai Dongfang , Chen Wei , Zheng Mingyue , Luo Qingquan , Xiao Yichuan , Huang Jia 
Published: January 2024

Abstract

Detection of cytoplasmic DNA is an essential biological mechanism that elicits IFN-dependent and immune-related responses. A better understanding of the mechanisms regulating cytoplasmic DNA sensing in tumor cells could help identify immunotherapeutic strategies to improve cancer treatment. Here we identified abundant cytoplasmic DNA accumulated in lung squamous cell carcinoma (LUSC) cells. DNA-PK, but not cGAS, functioned as a specific cytoplasmic DNA sensor to activate downstream ZAK/AKT/mTOR signaling, thereby enhancing the viability, motility, and chemoresistance of LUSC cells. DNA-PK–mediated cytoplasmic DNA sensing boosted glycolysis in LUSC cells, and blocking glycolysis abolished the tumor-promoting activity of cytoplasmic DNA. Elevated DNA-PK–mediated cytoplasmic DNA sensing was positively correlated with poor prognosis of human patients with LUSC. Targeting signaling activated by cytoplasmic DNA sensing with the ZAK inhibitor iZAK2 alone or in combination with STING agonist or anti-PD-1 antibody suppressed the tumor growth and improved the survival of mouse lung cancer models and human LUSC patient-derived xenografts model. Overall, these findings established DNA-PK–mediated cytoplasmic DNA sensing as a mechanism that supports LUSC malignancy and highlight the potential of targeting this pathway for treating LUSC.

Significance:
DNA-PK is a cytoplasmic DNA sensor that activates ZAK/AKT/mTOR signaling and boosts glycolysis to enhance malignancy and chemoresistance of lung squamous cell carcinoma.
A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer
Authors: Lechner Melissa G. , Brent Gregory A. 
Published: January 2024

SummaryAdvanced differentiated thyroid cancer that is resistant to radioactive iodine therapy may become responsive with a unique treatment combination of chloroquine and vorinostat. This treatment was demonstrated in cellular and animal models of thyroid cancer to inhibit endocytosis of the plasma membrane–bound iodine transporter, NIS, and restore iodine uptake.See related article by Read et al., p. 1352
Micronuclei and Cancer
Authors: Di Bona Melody , Bakhoum Samuel F. 
Published: January 2024

Abstract

Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our understanding of the mechanisms that govern micronuclei formation and their role in tumor progression. In this review, we provide a brief historical account of micronuclei, depict the mechanisms underpinning their creation, and illuminate their capacity to propel tumor evolution through genetic, epigenetic, and transcriptional transformations. We also posit the prospect of leveraging micronuclei as biomarkers and therapeutic targets in chromosomally unstable cancers.

Significance:
Micronuclei in chromosomally unstable cancer cells serve as pivotal catalysts for cancer progression, instigating transformative genomic, epigenetic, and transcriptional alterations. This comprehensive review not only synthesizes our present comprehension but also outlines a framework for translating this knowledge into pioneering biomarkers and therapeutics, thereby illuminating novel paths for personalized cancer management.
Tomar a favela para Jesus: ethos heróico, juventudes e pentecostalismos em territórios de exceção ordinária
Authors: Pereira Reia Sílvia Gonçalves , Mesquita Wania Amélia Belchior 
Published: January 2024

In the article, we present excerpts from the trajectory of Carlos, a young man who, after having his life threatened by members of a drug trafficking faction, joins a pentecostal church located in Campos do Goytacazes, Rio de Janeiro. The objective of this work is to analyze an aspect of the relations between drug dealers and Pentecostals in a favela territory. The study was divided into two parts: we present ethnographic data in the period between 2018 and 2020, of the favela Tira-Gosto, the church Caminhos das Águas and Carlos' trajectory. In the second part, the relationship between Pentecostals and traffickers, in favela territories. We argue that such relationships should also be analyzed from the perspective of the spiritual battle and what we call the heroic trajectory. We also argue that Pentecostal adherence in a context of ordinary exception, such as the daily life of the favela in question, is a possibility of affirming life.
Vocal performance of one affects that of another
Authors: Sockman Keith W. , Lyons Susan M. , Caro Samuel P. 
Published: January 2024

Abstract
The trill elements of many bird species’ songs have been hypothesized as honest signals of performance. However, the breadth of receiver responses to variation in the signaller’s trill performance is unknown. We exposed wild male Lincoln’s sparrows (Melospiza lincolnii) to two song treatments, one with low- and another with high-performance trills. We found no effect of treatment on measures of agonistic behaviour and song length. However, relative to the subjects’ trills following the high-performance treatment, those following the low-performance treatment were elevated in performance due to trill types with high frequency bandwidth in the third trill of songs. Treatment also affected trill duration through its syllable count in a manner that varied by the song’s trill number. Thus, the performance of a signal to which a receiver is exposed drives plasticity in his own performance in sequence-specific manner. Males may showcase their own performance in the presence of lower-performing rivals.
Worship, Culture, and the Contested Past
Authors: Wogu Chigemezi Nnadozie 
Published: January 2024

Abstract
This article is a product of an empirical study that argues that denominational worship praxis is a contested issue among Seventh-day Adventists (SDA s) in Nigeria today. Using analysis from fieldnotes and interviews, this article shows that there are some congregants who prefer to do worship as it was practiced by their denominational pioneers. This group keeps this memory sacred. Another group of Adventists contest the same past by leaning toward the Nigerian Pentecostal ethos. This contestation regarding the past combined with acceptance or rejection of cultural matters in the worship arena shows the diversity of Adventism in Nigeria. It also reveals how cultural and missionary traditions intersect and influence the local contemporary worship praxis of Adventist Christianity. Based on ethnographic findings, the article concludes that the example of conflicting visions of the past in one denomination (Seventh-day Adventists) in Nigeria contributes to a richer perspective in studies in world Christianity.
Xylodon asiaticus (Hymenochaetales, Basidiomycota), a new species of corticioid fungus from southern China
Authors: ZHANG XUNCHI , LI YUNCHAO , WANG YUYUN , XU ZHAN , ZHAO CHANGLIN , ZHOU HONGMIN 
Published: January 2024

The corticioid fungi are a cosmopolitan group and show a rich diversity, growing in the vegetation of boreal, temperate, subtropical, and tropical regions. Xylodon daii sp. nov. was found in the Yunnan Province, China, which suggested here to be new fungal species in light of their morphology and phylogeny. Xylodon daii has a coriaceous basidiomata with a hydnoid hymenophore and a monomitic hyphal system having generative hyphae with clamp connections, and ellipsoid to subcylindrical basidiospores measuring as 4–5.2 × 2.8–3.5 µm. Sequences of the ITS and nLSU rRNA markers of the studied samples were generated, and phylogenetic analyses were performed using the maximum likelihood, maximum parsimony, and Bayesian inference methods. After a series of phylogenetic studies, the ITS+nLSU analysis of the order Hymenochaetales indicated that, at the generic level, six genera, (i.e., Fasciodontia, Hastodontia, Hyphodontia, Lyomyces, Kneiffiella and Xylodon) were accommodated the members of Hyphodontia sensu lato, and the genus Xylodon grouped with Lyomyces within the Hymenochaetales. According to a further analysis of the ITS dataset, X. daii was nested into the genus Xylodon, in which it was retrieved as a sister to X. pseudotropicus.
Determination of Alzheimer's disease based on morphology and atrophy using machine learning combined with automated segmentation
Authors: Ikemitsu Natsuki , Kanazawa Yuki , Haga Akihiro , Hayashi Hiroaki , Matsumoto Yuki , Harada Masafumi 
Published: January 2024

Background To evaluate the degree of cerebral atrophy for Alzheimer's disease (AD), voxel-based morphometry has been performed with magnetic resonance imaging. Detailed morphological changes in a specific tissue area having the most evidence of atrophy were not considered by the machine-learning technique. Purpose To develop a machine-learning system that can capture morphology features for determination of atrophy of brain tissue in early-stage AD and classification of healthy participants or patients. Material and Methods Three-dimensional T1-weighted (3D-T1W) data were obtained from AD Neuroimaging Initiative (200 healthy controls and 200 patients with early-stage AD). Automated segmentation of 3D-T1W data was performed. Deep learning (DL) and support vector machine (SVM) were trained using 66-segmented volume values as input and AD diagnosis as output. DL was performed using 66 volume values or gray matter (GM) and white matter (WM) volume values. SVM learning was performed using 66 volume values and six regions with high variable importance. 3D convolutional neural network (3D-CNN) was trained using the segmented images. Accuracy and area under curve (AUC) were obtained. Variable importance was evaluated from logistic regression analysis. Results DL for GM and WM volume values, accuracy 0.6; SVM for all volume values, accuracy 0.82 and AUC 0.81; DL for all volume values, accuracy 0.82 and AUC 0.8; 3D-CNN using segmental images of the whole brain, accuracy 0.5 and AUC 0.51. SVM using volume values of six regions, accuracy 0.82; image-based 3D-CNN, highest accuracy 0.69. Conclusion Our results show that atrophic features are more considerable than morphological features in the early detection of AD.
Revisiting the Case of Ethnography and International Relations
Authors: Rio Anna Eriksen 
Published: January 2024

This article revisits the debate on the role of ethnography in International Relations. It primarily does this by elucidating three points of tension in the literature on ethnography in International Relations. Firstly, it tackles the challenges related to ‘getting on’ with ethnography after the reflexive methodological developments that have taken place within anthropology since the 1980s. Secondly, it investigates how to overcome certain matters of scale and how to conceptualise the ‘international’ methodologically, or more specifically, ethnographically. When looking at issues that somehow exist and operate on the international scale, the ethnographic task of immersion in local scenes does sometimes seem like an ill-suited approach. However, I argue, this problematisation is dependent on a certain methodological understanding of what the international is. I attempt to formulate an alternative methodological approach that takes seriously the idea that international relations always can be accessed locally. This paper suggests that one of the main solutions to the obstacle of scale is methodologically abandon the imaginary of totalities as a higher level. In this way, ethnography can enable important understandings of social relations that exist across scales of local and global. Repenser le rapport entre l’ethnographie et les relations internationales
Diagnostic evaluation of deep learning accelerated lumbar spine MRI
Authors: Awan Komal M , Goncalves Filho Augusto Lio M , Tabari Azadeh , Applewhite Brooks P , Lang Min , Lo Wei-Ching , Sellers Robert , Kollasch Peter , Clifford Bryan , Nickel Dominik , Husseni Jad , Rapalino Otto , Schaefer Pamela , Cauley Stephen , Huang Susie Y , Conklin John 
Published: January 2024

Background and Purpose Deep learning (DL) accelerated MR techniques have emerged as a promising approach to accelerate routine MR exams. While prior studies explored DL acceleration for specific lumbar MRI sequences, a gap remains in comprehending the impact of a fully DL-based MRI protocol on scan time and diagnostic quality for routine lumbar spine MRI. To address this, we assessed the image quality and diagnostic performance of a DL-accelerated lumbar spine MRI protocol in comparison to a conventional protocol. Methods We prospectively evaluated 36 consecutive outpatients undergoing non-contrast enhanced lumbar spine MRIs. Both protocols included sagittal T1, T2, STIR, and axial T2-weighted images. Two blinded neuroradiologists independently reviewed images for foraminal stenosis, spinal canal stenosis, nerve root compression, and facet arthropathy. Grading comparison employed the Wilcoxon signed rank test. For the head-to-head comparison, a 5-point Likert scale to assess image quality, considering artifacts, signal-to-noise ratio (SNR), anatomical structure visualization, and overall diagnostic quality. We applied a 15% noninferiority margin to determine whether the DL-accelerated protocol was noninferior. Results No significant differences existed between protocols when evaluating foraminal and spinal canal stenosis, nerve compression, or facet arthropathy (all p > .05). The DL-spine protocol was noninferior for overall diagnostic quality and visualization of the cord, CSF, intervertebral disc, and nerve roots. However, it exhibited reduced SNR and increased artifact perception. Interobserver reproducibility ranged from moderate to substantial (κ = 0.50–0.76). Conclusion Our study indicates that DL reconstruction in spine imaging effectively reduces acquisition times while maintaining comparable diagnostic quality to conventional MRI.
Stifle arthrodesis in a feline pelvic limb amputee
Authors: Goh Wei Tze , Drew Jarrod 
Published: January 2024

Case summary A domestic shorthair cat presented to the Animal Referral Hospital (Brisbane, Australia) after having the left pelvic limb incorrectly amputated. The cat was unable to ambulate on the remaining right pelvic limb due to a chronically subluxated stifle. A stifle arthrodesis was performed on the right pelvic limb to manage the injury. Follow-up radiographs performed 5 months postoperatively demonstrated stifle arthrodesis with no detectable complications. The owner reported that aside from some difficulties in toileting, the cat had a good quality of life and was capable of performing the majority of daily activities. Stifle arthrodesis in a feline pelvic limb amputee appears to be a viable treatment option. After a period of rehabilitation and adaptation, the cat in the case report has been able to lead a near-normal lifestyle. Relevance and novel information To the authors’ knowledge, this is the first report of the outcome and complications associated with stifle arthrodesis in a feline pelvic limb amputee. This is also the first report of stifle arthrodesis in a cat using the bilateral plating technique.
Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia
Authors: Eldfors Samuli , Saad Joseph , Ikonen Nemo , Malani Disha , Vähä-Koskela Markus , Gjertsen Bjørn T. , Kontro Mika , Porkka Kimmo , Heckman Caroline A. 
Published: January 2024

Abstract
Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of patients with acute myeloid leukemia (AML). Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-7q. Therefore, we aimed to identify novel vulnerabilities. Through an analysis of data from ex vivo drug screens of 114 primary AML samples, we discovered that -7/-7q AML cells are highly sensitive to the inhibition of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is the rate-limiting enzyme in the nicotinamide adenine dinucleotide salvage pathway. Mechanistically, the NAMPT gene is located at 7q22.3, and deletion of 1 copy due to -7/-7q results in NAMPT haploinsufficiency, leading to reduced expression and a therapeutically targetable vulnerability to the inhibition of NAMPT. Our results show that in -7/-7q AML, differentiated CD34+CD38+ myeloblasts are more sensitive to the inhibition of NAMPT than less differentiated CD34+CD38– myeloblasts. Furthermore, the combination of the BCL2 inhibitor venetoclax and the NAMPT inhibitor KPT-9274 resulted in the death of significantly more leukemic blasts in AML samples with -7/-7q than the NAMPT inhibitor alone. In conclusion, our findings demonstrate that AML with -7/-7q is highly sensitive to NAMPT inhibition, suggesting that NAMPT inhibitors have the potential to be an effective targeted therapy for patients with monosomy 7 or del(7q).
RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer
Authors: Lai Yuexing , Dong Hairong , Xu Ping , Wang Jing , Feng Wen , Zhao Zhenya , Sha Linyu 
Published: January 2024

Abstract
Background
The m6A modified demethylase FTO affects the progression of gastric cancer (GC), and the role mechanism of FTO in GC is still unclear. We, here, explored the role of FTO and unrevealed the mechanisms of its function in GC.

Methods
The expression and clinical prognosis of FTO in GC were examined via UALCAN and GEPIA online databases. Effect of FTO shRNA on GC cellular malignant phenotype were proved by CCK-8, Transwell, Wound healing assay and Flow cytometric assay. RNA-sequencing data of FTO depleted AGS cells were downloaded to analyze differentially expressed genes of FTO downstream. The GO and KEGG pathway enrichment were performed for the DEGs by DAVID. RT-qPCR and RIP-qPCR assay were applied to verify the MOXD1 mRNA and methylated mRNA in FTO shRNA group. The expression and clinical prognosis of MOXD1 in GC were explored via UALCAN, GEPIA and Kaplan-Meier plotter. The role and mechanism and of MOXD1 in GC cell lines were detected and analyzed.

Results
The expression of FTO was found to be elevated in GC tissues compared with normal tissues, and worse survival were strongly related to high expression of FTO in GC. FTO silencing suppressed the proliferation, migration and promoted apoptosis of GC cells. A total of 5856 DEGs were obtained in between NC and FTO depleted AGS cell groups, and involved in the cancer related pathways. Here, FTO targets MOXD1 mRNA and promotes its expression via m6A methylation. MOXD1 upregulation was associated to poor prognosis of GC. MOXD1 silencing suppressed the malignant phenotype of GC cells. MOXD1 activated cancer -related signaling pathway (MAPK, TGF-β, NOTCH and JAK/STAT).

Conclusions
Our study demonstrated that FTO silencing decreased MOXD1 expression to inhibit the progression of GC via m6A methylation modification. FTO/MOXD1 may be potential targets for the treatment and prognosis of GC.
Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China
Authors: Huang Rui , Shang Jia , Chen Hong , Li Jun , Xie Qing , Feng Jiajun , Wei Lai , Rao Huiying 
Published: January 2024

Abstract
Background
To investigate the trends in health-related quality of life (HRQoL) among hepatitis C virus (HCV) patients and to assess the longitudinal impact of antiviral therapy on their well-being.

Methods
In this prospective multicenter observational study in adults with HCV infection, sociodemographic, clinical characteristics and EQ-5D questionnaires were collected. Generalized estimating equation (GEE) models were used to assess the associations between these variables and changes in HRQoL over time.

Results
456 patients were included, with a median age of 46.5 (36.5–57.0) years, of which 262 (57.5%) were males and 44 (9.6%) had cirrhosis. 335 patients (73.5%) receiving antiviral therapy and 61.8% achieved sustained virologic response (SVR). The baseline EQ-5D utility and EQ-VAS were 0.916 ± 0.208 and 80.6 ± 13.0. In multivariable analysis of GEE estimation, achieving SVR24 was positively associated with EQ-5D utility (p = 0.000) and EQ-VAS (p = 0.000) over time. Age and income were shown to be significant predictors of EQ-5D utility, while gender, age and genotype were associated with EQ-VAS over time.

Conclusions
SVR improved long-term HRQoL in HCV patients in the first few years following viral clearance. Certain sociodemographic factors, such as gender, age, income as well as genotype, significantly influenced long-term changes in patients’ quality of life.

Trial registration
NCT01594554. Registration date: 09/05/2012.