bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential Design for Quantile Estimation in Multifactor Sensitivity Experiments
Authors: Bai Tian , Wang Dianpeng , Chen Kuangqi , Tian Yubin 
Published: February 2025

ABSTRACTCavitation in hydrofoil experiments is a critical physical phenomenon, which is primarily influenced by three key factors. Efficiently identifying the combination of factor levels at which cavitation occurs with 50% probability presents a significant challenge in sensitivity testing, particularly when constrained by the high cost of hydrofoil experiments. Despite its importance, sensitivity experiments with multiple factors have received scant attention in literature. In order to tackle this challenge, we propose a novel sequential design based on the upper credible bound criterion for the generalised Gaussian process models, which is used to model the hydrofoil experimental data. Some numerical simulation studies demonstrate that the proposed method effectively balances exploitation and exploration, achieving superior performance compared to existing approaches. Finally, a practical application to hydrofoil cavitation experiments validates the superiority of the proposed method.
Exploring Smart Life
Authors: Kornyshova Elena , Deneckère Rébecca , Benramdane Kamal Mustapha , Brinkkemper Sjaak 
Published: February 2025

Abstract
In the contemporary landscape of technological advancement, the concept of Smart Life has emerged as a multifaceted domain, encapsulating a myriad of interconnected elements that deeply influence our daily experience. A lot of research works are published on this topic each month, and new devices continue to appear. However, after examining the existing literature, we found out the need for a consistent definition of Smart Life. This chapter addresses this limitation by providing a more precise definition of the Smart Life concept. We present various terms related to “Smart,” characterize in detail the concept of Smart Life, present a systemic view on this topic, and, finally, introduce the basic elements for Smart Life governance.
ADR for Consumer Disputes in the Consumer Protection Legislation of North Macedonia
Authors: Zdraveva Neda 
Published: January 2025

Abstract
Alternative Dispute Resolution (ADR) is a mechanism that allows consumers and traders to resolve disputes efficiently and effectively. The European Union (EU) has a comprehensive framework for ADR, which is currently under revision. This revision aims to adapt the ADR framework to digital markets, enhance access to ADR in cross-border disputes through digital tools, and streamline ADR procedures. The Directive on Consumer ADR encompasses all categories of disputes pertaining to EU consumer rights and encourages traders to increase their participation in ADR claims through the duty to respond. In North Macedonia, a new Consumer Protection Law, transposing various EU directives related to consumer protection, came into effect in 2022. This law contributes to establishing a legal framework that ensures a higher level of consumer rights protection. It also provides mechanisms for swiftly resolving disputes between traders and consumers. The law favours alternative dispute resolution mechanisms, but the legal framework for ADR in consumer disputes is yet to be fully established. In summary, both the EU and North Macedonia have robust frameworks for consumer protection. These frameworks aim to safeguard consumer rights, ensure fair trade practices, and provide effective mechanisms for dispute resolution. As the EU legislation and practices in this field are evolving and improving, policymakers and enforcement agencies in North Macedonia are yet to catch up and provide an environment conducive to ADR for consumer disputes.
A Note on the Historiography of Pre-modern Connexive Logic
Authors: Wansing Heinrich , Omori Hitoshi 
Published: February 2025

Abstract
The historiography of connexive logic has seen some pitfalls. In the present note, we show that the reception of principles characteristic of connexive logic provides an example of how an unwarranted bias in favor of what is now called ‘classical logic’ and an often accompanying aversion against contradictions can negatively affect the historiography of logic. Moreover, we briefly outline the coverage of the present volume 60 Years of Connexive Logic.
Ten Open Problems in Connexive Logic
Authors: Omori Hitoshi , Wansing Heinrich 
Published: February 2025

Abstract
In this short note, which is the final chapter of the volume 60 Years of Connexive Logic, we list ten open problems. Some of these problems are technical and precisely stated, while others are less technical and even speculative. We hope that the list inspires some readers to contribute to the field by tackling one or many of the problems.
A family affair? Long-term economic and mental health effects of spousal cancer
Authors: Böckerman Petri , Kortelainen Mika , Salokangas Henri , Vaalavuo Maria 
Published: February 2025

Abstract
Research on the family spillover effects of health shocks, which has focused mainly on labor market outcomes, has yielded inconclusive results, with limited insight into long-term consequences or underlying mechanisms. We analyze the short- and long-term impacts of cancer on the unaffected spouse’s labor supply and mental health as well as marital stability, considering gender and relative income status within the households. Using population-based register data from Finland (1995–2019) and a dynamic difference-in-differences design, we observe two key findings. First, a cancer diagnosis leads to very modest changes in a spouse’s labor supply but significant increases in the likelihood of psychotropic drug use and psychiatric outpatient visits. Second, the main results mask considerable heterogeneity regarding relative income within the household. Secondary earners increase their labor supply in response to fatal cancers but decrease it in non-fatal cases, while breadwinners show small negative responses in both. Bereaved women with lower income share experience more psychiatric symptoms, a trend not observed in men. Our findings reveal the importance of pre-shock breadwinner status in family responses to health shocks, suggesting the need for targeted support for caregiving and bereaved spouses.
Tat_BioV: tattoo ink exposure and biokinetics of selected tracers in a short-term clinical study of 24 subjects
Authors: Kochs Susanne , Schiewe Sandra , Foerster Milena , Hillmann Kathrin , Blankenstein Claudia , Meinke Martina C. , Kugler Josephine , Kocovic David , Luch Andreas , Blume-Peytavi Ulrike , Schreiver Ines 
Published: January 2025

Abstract
About one-fifth of people in industrialised countries are tattooed, potentially putting them at risk of exposure to possible carcinogenic or otherwise harmful substances. This study aims to determine the exposure to soluble tattoo ink ingredients and their excretion within 24 h after tattooing. In this clinical study, 24 subjects were tattooed with black or red tattoo ink to which the 3 tracer substances, potassium iodide, 4-aminobenzoic acid (PABA) and 2-phenoxyethanol (PEtOH), had been added to mimic known substances found in tattoo inks. Tracers and their metabolites were quantified in blood, urine, ink and consumables pre- and post-tattooing. Tattooed skin area was determined using picture analysis. PABA metabolism upon tattooing was compared to peroral administration. Skin fibroblasts and macrophages were tested in vitro for their ability to metabolise PABA. All tracers or their metabolites were identified in urine; iodide and the PABA metabolite 4-acetamidobenzoic acid (ACD) were identified in plasma. The worst-case scenario for systemic ink exposure was estimated to be 0.31 g ink per tattoo session (75th percentile). Peroral administration resulted in lower levels of ACD than tattooing. Fibroblasts and macrophages were capable of converting PABA into ACD. Our results are the first human in vivo data on soluble tattoo ink ingredients and suggest that the overall exposure might be lower than the estimates previously used for regulatory purposes. In addition, the first-pass effect by skin metabolism leads to an altered metabolite profile compared to oral exposure. Skin metabolism might also contribute to detoxification of certain carcinogenic substances through N-acetylation.
Influence of cognitive demand and auditory noise on postural dynamics
Authors: Carey Sam , Balasubramaniam Ramesh 
Published: February 2025

Abstract
The control of human balance involves an interaction between the human motor, cognitive, and sensory systems. The dynamics of this interaction are yet to be fully understood, however, work has shown the performance of cognitive tasks to have a hampering effect on motor performance, while additive sensory noise to have a beneficial effect. The current study aims to examine whether postural control will be impacted by a concurrent working memory task, and similarly, if additive noise can counteract the expected negative influence of the added cognitive demand. Postural sway of healthy young adults was collected during the performance of a modified N-back task with varying difficulty, in the presence and absence of auditory noise. Our results show a reduction in postural stability scaled to the difficulty of the cognitive task, but this effect is less prominent in the presence of additive noise. Additionally, by separating postural sway into different frequency bands, typically used to assess the exploratory vs feedback-driven stabilizing dynamics of sway, we found a differential effect between the cognitive task and additive noise, thus demonstrating that both frequency regimes of postural sway are sensitive to high cognitive load and increased sensory information.
Slide laryngotracheopexy for idiopathic subglottic stenosis
Authors: Tóbiás Zoltán , Bach Ádám , Szakács László , Csanády Miklós , Ambrus Andrea , Rovó László 
Published: February 2025

Abstract

Objectives
Idiopathic subglottic stenosis (iSGS) is a rare fibroinflammatory disorder characterized by scar tissue formation in the subglottic and tracheal regions. This study evaluated the long-term outcomes of a novel, single-step surgical technique that redefines the glottic and subglottic airway using local tracheal grafts.

Methods
Thirteen patients (2 male and 11 female) diagnosed with iSGS who underwent slide laryngotracheopexy were enrolled in this study. The diagnosis of iSGS was confirmed through endoscopic assessment, CT scanning, and autoimmune blood testing. Patients completed post-operative Voice Handicap Index (VHI), Quality of Life (QoL), and MD Anderson Dysphagia Inventory (MDADI) questionnaires, and spirometry assessments were conducted.

Results
All patients were successfully extubated in the operating room following surgery. None of the patients required intensive care unit treatment. The average hospital stay was 14 days. A temporary tracheotomy was needed in one case because of excessive crusting. Adjuvant endolaryngeal laser surgery was performed in three cases. In one case, mitomycin-C therapy was administered to treat granulation. Post-operative quality of life (QoL) assessment, peak inspiratory flow (PIF), and scores from the MDADI and VHI questionnaires were 9.0 (± 2.2), 2.8 l/s (± 0.83), 95.6 (± 4.3), and 18.7 (± 13.4), respectively.

Conclusion
Slide laryngotracheopexy was a safe and dependable technique for cases classified as Cotton-Myers II-IV grade iSGS. The use of a tracheal flap was advantageous to ensure optimal mucosal function. Slide laryngotracheopexy may be employed following multiple endolaryngeal interventions, whereas adjuvant CO2 laser surgery or mitomycin-c therapy may be considered in cases involving granulation tissue formation.

Level of evidence
4.

Study Design
Retrospective case series review.
Hippocampal dysfunction after autoimmune encephalitis depending on the antibody type
Authors: Hänsel Martin , Reichmann Heinz , Haehner Antje , Schmitz-Peiffer Henning , Schneider Hauke 
Published: February 2025

Abstract

Background
Comprehensive neurocognitive function analyses of autoimmune encephalitis (AE) patients, especially long-term ones, are rare. This study aims to measure cognitive function in patients diagnosed with AE.

Methods
This case–control study included AE patients (n = 11) with antibodies against NMDA receptor (NMDAR) (n = 4), VGKC (n = 3), GAD (3), and one antibody-negative patient. The control group contained 12 pneumococcal meningo-encephalitis patients (PC). Subgroup analyses compared AE patients with and without NMDAR antibodies. Neurocognitive tests were performed to evaluate verbal and visual memory, face recognition, attentional capacity, incidental learning capacity, and overall cognitive function (Montreal cognitive assessment, MoCA). Limbic structural involvement was assessed through magnetic resonance imaging (MRI). Statistical analyses investigated correlations between antibody status, results of neurocognitive tests, and MRI findings.

Results
Follow-up (AE vs. PC) was 33 (11–95) vs. 96 (26–132) months after diagnosis. Neurocognitive functions were normal in both AE and PC groups in all tests except face recognition, which was pathological in both groups. The overall/recognition/long-delay visual memory (p = 0.009/0.008/0.005) and incidental learning (p = 0.017) scores were significantly higher in NMDAR patients compared to non-NMDAR patients. Non-NMDAR patients with right-sided limbic MRI pathologies had significantly lower overall/recognition/long-delay visual memory (p = 0.006/0.044/0.024) and incidental learning (p = 0.009) scores compared to NMDAR patients.

Conclusions
We observed mainly normal neurocognitive functions after autoimmune and bacterial encephalitis. However, compared to NMDAR patients, patients with non-NMDAR autoimmune encephalitis showed a significant and material-specific association between a right-sided hippocampal lesion and limitations in figural-mnestic and incidental learning capacities. Neurocognitive functions in AE patients should be further evaluated prospectively and in more detail.
Serum chitotriosidase-1 (CHIT1) as candidate biomarker for mitochondriopathies
Authors: Foerster Laura , Scholle Leila , Mayer Tobias , Schneider Ilka , Stoltenburg-Didinger Gisela , Delank Karl-Stefan , Kraya Torsten , Hahn Andreas , Strube David , Koelsch Anna Katharina , Naegel Steffen , Barba Lorenzo , Volk Alexander E. , Otto Markus , Mensch Alexander 
Published: February 2025

Abstract

Background
Neuromuscular diseases (NMDs) and mitochondriopathies are rare and heterogeneous disorders. Diagnosis is often difficult and delayed, partly due to the lack of reliable biomarkers. Chitotriosidase (CHIT1) as a candidate marker for lysosomal storage diseases is elevated in Niemann pick disease type C as a prototype of this group of diseases. Most recently, a relevant role of the lysosomal pathway in mitochondriopathies has been discussed, but markers of lysosomal involvement have not been investigated. Therefore, the aim of this study was to evaluate CHIT1 concentrations in a broad spectrum of NMDs and mitochondriopathies.

Methods
CHIT1 serum concentration of 151 patients with NMD or primary mitochondriopathy was determined by enzyme-linked immunosorbent assay, and compared to 38 healthy controls and 8 patients with Niemann pick disease type C. Results were controlled for age, sex, CRP and CHIT1 polymorphism, and compared to several established markers (CK, FGF21, GDF15).

Results
CHIT1 levels were not altered in NMDs, but significantly increased in mitochondriopathies, within the range of Niemann-Pick patients. Compared to the established biomarkers, CHIT1 and FGF21 showed a similar diagnostic performance, while better results were found for GDF15. However, there was a tendency for higher CHIT1 concentrations in patients with central nervous system involvement (MELAS syndrome), while FGF21 and GDF15 were not relevantly altered in these patients. Consequently, a combination of biomarkers including CHIT1 provided the best overall diagnostic performance.

Conclusions
Serum CHIT1 concentration is significantly elevated in mitochondriopathies compared to healthy controls and other NMD, identifying CHIT1 as potential complementary biomarker in mitochondriopathies.
Shifting perspectives: an investigation of a virtual reality awe experience in people going through cancer treatment
Authors: Tao V. , Tennant G. , Clayden C. , Reynolds Lisa M. 
Published: February 2025

Abstract

Purpose
Evoking awe using virtual reality appears to be a promising intervention that has potential to positively impact physical and psychological well-being. The purpose of this exploratory study was to investigate the acceptability and potential benefits of a VR experience of awe for patients undergoing cancer treatment.

Methods
Twenty cancer patients viewed a 5-min VR nature experience designed to induce awe and completed questionnaires assessing anxiety, symptom distress, spirituality, and connectedness to nature. Qualitative interviews assessed acceptability and ways to improve the intervention.

Results
The VR experience effectively induced awe. Following the experience, participants reported decreased anxiety and symptom distress and increased feelings of spirituality and connectedness to nature. Participants enjoyed the experience and said they would use it again and would recommend it to others.

Conclusion
VR nature interventions that induce awe are worthy of future investigation as a psychological approach to support cancer patients undergoing treatment.
Isoperistaltic hand-sewn side-to-side bowel primary anastomosis: a safe approach after bowel resection in children with neutropenic enterocolitis
Authors: Taher Mohammad , Elshafiey Maged , Refaat Ahmed , Nasr Eman , Ahmed Gehad 
Published: February 2025

Abstract

Background and aim
Whether to perform primary anastomosis (PA) or create a stoma after bowel resection has always been a dilemma in pediatric cancer patients with neutropenic enterocolitis (NEC). The risk of leakage after PA must be weighed against the risk of stoma complications. We evaluated the outcomes of managing NEC patients with either PA or stoma and the utility of the isoperistaltic hand-sewn side-to-side anastomosis (ISSA) technique in PA.

Patients and methods
A retrospective study on all Children's Cancer Hospital Egypt patients with NEC who underwent surgical exploration at our hospital from 2008 to 2022.

Results
Of 153 children, 80 (52.3%) underwent PA and 73 (47.7%) underwent stoma formation. Among the 80 PA patients, 68 (85%) underwent ISSA, 9 (11.2%) end-to-end anastomosis (EEA), and 3 (3.8%) end-to-side anastomosis (ESA). The perioperative complication rate was 38/73 (52.1%) in the stoma patients and 35/80 (43.8%) in the PA patients. Leakage occurred in 6/68 (8.8%) ISSA patients, 5/9 (55.6%) EEA patients, and 1/3 (33.3%) of ESA patients.

Conclusions
In pediatric cancer patients with NEC, PA using ISSA after bowel resection is considered a better approach than any other anastomotic configuration.
Hydrazine imprinted electrochemical sensor based on cobalt-barium stannate nanoparticles incorporated-functionalized MWCNTs nanocomposite for hydrazine determination in tap water samples
Authors: Gül Fatma Hazan , Deveci Hacı Ahmet , Deveci Ayla , Akyıldırım Onur , Yola Mehmet Lütfi 
Published: February 2025

Abstract
A hydrazine (HYD) detection method is presented based on molecularly imprinting polymers (MIPs) and cobalt-barium stannate nanoparticles incorporated-functionalized MWCNTs (CBSNPs/f-MWCNTs) nanocomposite. Firstly, co-precipitation and sonication techniques were applied to the preparations of CBSNPs and CBSNPs/f-MWCNTs nanocomposite, respectively. Since waste generation occurs at a minimum level in these techniques, an environmentally friendly nanocomposite was prepared. After the glassy carbon electrode modification with CBSNPs and CBSNPs/f-MWCNTs nanocomposite, HYD imprinted electrodes were fabricated using cyclic voltammetry (CV) with a dispersion containing 100.0 mM pyrrole (Py) monomer and 25.0 mM HYD molecule. The resulting electrochemical sensor demonstrated a detection span of 1.0 × 10−9 M to 1.0 × 10−8 M HYD and achieved a detection limit (LOD) of 3.0 × 10−10 M. Furthermore, the developed electrochemical sensor was used for actual tap water samples, and the obtained values close to 100.00% in recovery experiments showed the high accuracy of the developed sensor in real sample analysis. Finally, the selectivity, stability, and reproducibility of the created electrochemical sensor were investigated, and the developed sensor has been demonstrated to have high stability for at least 7 weeks, high reproducibility with a relative standard deviation (RSD) value of 0.14%, and high selectivity in real samples.

Graphical Abstract
Rebamipide for management of methotrexate-induced oral ulcers: a three-arm randomized clinical trial
Authors: Abdelaziz Amira , Shamma Rehab Nabil , Fayed Hala Lotfy , Ali Shereen 
Published: February 2025

Abstract

Objectives
This RCT aimed to evaluate the effect of topical Rebamipide (regular and nanoparticulated) in comparison to topical Clobetasol propionate in the management of methotrexate-induced oral ulcers in rheumatoid arthritis patients.

Materials and methods
Patients were divided randomly into three parallel arms: 1% Rebamipide; 1% nanoparticulated Rebamipide, Clobetasol propionate. The outcome measures included WHO oral mucositis grading, pain (NRS), ulcer size, and healing time. The data was analyzed for any statistical significance.

Results
Intragroup comparisons of mucositis grade improvement and pain reduction revealed significant differences in all the groups. All intergroup comparisons demonstrated non-significant difference, yet nanoparticulated Rebamipide was leading, and all group participants achieved complete healing earlier than the other groups.

Conclusion
Rebamipide, regular and nanoparticulated forms, showed comparable results to potent Corticosteroid, Clobetasol propionate in management of the oral ulcers.

Clinical relevance
Rebamipide is an efficient promising alternative modality for management of methotrexate-induced oral ulcers in rheumatoid arthritis patients.
Genome-Assisted Gene-Flow Rescued Genetic Diversity Without Hindering Growth Performance in an Inbred Coho Salmon (Oncorhynchus kisutch) Population Selected for High Growth Phenotype
Authors: Kobayashi Junya , Honda Ryo , Hosoya Sho , Nochiri Yuki , Matsuzaki Keisuke , Sugimoto Koichi , Nagano Atsushi J. , Kumagai Akira , Kikuchi Kiyoshi , Kurokawa Tadahide 
Published: February 2025

Abstract
Selective breeding is a powerful tool for improving aquaculture production. A well-managed breeding program is essential, as populations can otherwise lose genetic diversity, leading to reduced selection response and inbreeding excesses. In such cases, genetic diversity in broodstock must be restored by introducing individuals from external populations. However, this can reduce the accumulated genetic gains from selective breeding. However, the selective introduction of individuals with superior phenotypes will allow the restoration of genetic diversity without sacrificing these gains. In this study, we demonstrated this possibility using a selectively bred (SB) and a randomly bred (RB) population of coho salmon (Oncorhynchus kisutch). Forty males with superior growth were selected from the RB population using genomic selection and crossed with 127 randomly collected females from the SB population, producing a newly bred (NB) population. Genetic diversity, assessed from population statistics such as effective number of alleles, allele richness, and observed heterozygosity of 11 microsatellite markers, was higher in NB than in SB and RB. Additionally, fork length and body weight were compared among the three populations after 12 months of growth post-fertilization in common tanks. The least-squares means of fork length and body weight were similar between NB (164.9 mm and 57.9 g) and SB (161.1 mm and 53.7 g), while both were significantly greater than RB (150.4 mm and 43.0 g). Our results highlight the effectiveness of genome-assisted gene flow in restoring the genetic diversity of a population without compromising accumulated genetic gain in growth.