bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular biological methods to assess differentBotrytis cinereastrains on grapes
Authors: Backmann Louis , Schmidtmann Katharina , Wegmann-Herr Pascal , Jürgens Andreas , Scharfenberger-Schmeer Maren 
Published: January 2024

AbstractBotrytis cinereais a well-known pathogen that can be challenging to control in crops, such as wine grapes. To adapt to the increasing problems of climate change and strain resistance it is important to find new methods to detectBotrytis cinereaand differentiate strains. These methods include strain differentiation and classification by simple sequence repeats (SSRs) and early detection of the fungus by qPCR. Various strains were analysed using SSR markers and either agarose gel electrophoresis or capillary sequencing via PCR. A sensitive qPCR method was refined to achieve an early detection method for the pathogen. The results demonstrate promising ways to distinguish between strains using both agarose gel electrophoresis and capillary sequencing as well as to detect infection before it becomes visible on grapes. This can be used to further understand and analyse differentBotrytis cinereastrain characteristics such as laccase activity, regional or annual effects. The early detection method can be used to better prepare growers for an impending infection so that targeted efforts can be made.
Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy
Authors: Montani Caterina , Galbusera Alberto , D’Epifanio Bianca , Ghirardini Elsa , Cornuti Sara , Pasquin Mariani Jean-Charles Rene’ , Guzman A. Elizabeth De , Bertozzi Sine Mandrup , Armirotti Andrea , Baroncelli Laura , Gozzi Alessandro 
Published: January 2024

AbstractCreatine Transporter Deficiency (CTD) is an X-linked disease due to the loss ofSLC6A8gene and presenting with low brain creatine, intellectual disability, autistic-like behavior and seizures. No treatments are available yet for CTD, and little is known about the brain circuit alterations underlying its pathological endophenotypes. Here, we tracked brain network and behavioral dysfunction in a murine model of CTD at two stages of disease progression. fMRI mapping revealed widespread disruption of brain connectivity in Slc6a8-KO mutants, with prominent somato-motor dysconnectivity in juvenile mice, and weaker and more focal cortical and subcortical hypoconnectivity in adults. Notably, perinatal AAV-mediated expression of humanSLC6A8in Slc6a8-KO mutants significantly rescued juvenile fMRI hypoconnectivity. This effect was paralleled by a regression of translationally relevant phenotypes, including a reduction in stereotyped movements and increased body weight which persisted into adulthood. Cognitive deficits and residual fMRI hypoconnectivity in adult mice were instead not reverted by gene therapy. Finally, multivariate modeling in adult mice revealed a basal forebrain network whose activity was associated with behavioral performance, and modulated by brain creatine levels. This brain-behavior relationship was disrupted in Slc6a8-KO mutants. Our results document robust network disruption in CTD and demonstrate that CTD pathology can be partially reversed by perinatal genetic expression ofSLC6A8, thus laying the basis for the development of experimental therapies for this genetic disorder.
Exploring the role of workforce agility on digital transformation: a systematic literature review
Authors: Muduli Ashutosh , Choudhury Anuva 
Published: January 2024

PurposeSuccessful digital transformation requires a change in organisational structures, processes, capabilities and competencies. Digital transformation research is more influenced by the technology adaptation model and hence focuses on people's attitudes, behaviour and abilities. Recently, employee agility has attracted attention in the context of technology adoption and Industry 4.0. The current research explores the relationship between employee agility and digital technology adoption in the context of digital transformation by adopting the systematic literature review method.Design/methodology/approachFollowing the attitude–ability-behaviour–outcome framework, the research explored the specific agile ability, attitude and behaviour characteristics useful for digital transformation. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) framework consisting of (1) initiation, (2) screening, (3) evaluation and (4) confirming inclusion (Ambika et al., 2023), the study identified 19 papers from SCOPUS indexed journals.FindingsThe study result found that agile attitude characteristics such as collaborative mindset, computer self-efficacy, ambiguity aversiveness, etc. are influencing the digital transformation process. Agile abilities like basic computer knowledge, previous technical experience, cognitive abilities, innovation capability, digital competence training and supporting proper knowledge management practices also influence digital transformation. Finally, agile behaviour such as relationship building, knowledge-sharing behaviour, promoting values of learning, risk-taking and experimenting, rewarding innovativeness and customer-centric innovation and displaying adaptability, resilience and commitment to change, etc. are found to drive digital transformation.Originality/valueResearch on workforce agility and digital transformation is scarce. The current study contributes to benchmarking research by exploring specific agile attitudes, abilities and behaviour characteristics relevant to digital transformation, especially in the era of Industry 4.0.
Is your employer branding strategy effective? The role of employee predisposition in achieving employer attractiveness
Authors: Hein Antonia Z. , Elving Wim J.L. , Koster Sierdjan , Edzes Arjen 
Published: January 2024

PurposeEmployer branding (EB) has become a powerful tool for organizations to attract employees. Recruitment communication ideally reveals the image that companies want to portray to potential employees to attract talents with the right skills and competences for the organization. This study explores the impact of EB on employer attractiveness by testing how pre-existing employee preferences interact with EB and how this interaction affects employer attractiveness.Design/methodology/approachA quasi-experiment among 289 final-year students was used to test the relationships between EB, perceived employer image, person-organization (P-O) fit and employer attractiveness, and the potential moderating variables of pre-existing preferences, in this case operationalized as locational preferences. Students are randomly assigned to four vacancies: one with and one without EB cues in two different locations: Groningen and Amsterdam. The authors used standard scales for attractiveness, perceptions of an employer and person-organization fit. The authors test the relationships using a regression analysis.FindingsResults suggest that if respondents have previous predispositions, then their preference can be enhanced using an EB-targeted strategy. Based on these results, the authors can conclude that EB and related practices can be successful avenues for organizations in the war for talent, particularly if they reaffirm previous preferences of potential employees.Originality/valueThe research is original in the way it provides empirical evidence on the relationship between EB and attractiveness, particularly when previous employee preferences exist. This is of value to employers using EB as a tool to influence employer attractiveness.
Actor-agency and institutional complexity: multinational corporations’ strategies to combat the framework convention on tobacco control in Brazil
Authors: Baldi Mariana , de Bakker Frank G.A. , Melz Rodrigo Luís 
Published: January 2024

Purpose
This study aims to analyse the strategic moves used by major tobacco corporations to thwart the ratification of the World Health Organization’s Framework Convention on Tobacco Control (FCTC) in Brazil.

Design/methodology/approach
The authors conducted a detailed historical case study spanning 1988–2005 and encompassing the period leading up to Brazil’s FCTC ratification. The authors collected qualitative data from various sources to triangulate and develop a comprehensive historical account.

Findings
The historical analysis identified three distinct phases. First, the acquisition of a Brazilian cigarette factory, Souza Cruz, by British American Tobacco dramatically altered power dynamics, strengthening the position of the tobacco industry. The second phase regards the era of dictatorship and the efforts of various actors advocating against smoking and the tobacco industry. The third phase involved Brazil’s re-democratisation and the challenges of securing FCTC ratification, during which fierce industry opposition had to be overcome. Throughout these phases, the authors identified four key strategies used by multinational corporations (MNCs) in Brazil to uphold unsustainable practices and products that contradicted public interests instead of reforming them: shaping collective memory, dissimulation, re-presentation and redirecting attention.

Originality/value
This study contributes to critical international business research on emerging economies by examining how Brazil’s position in the global capitalist system has influenced its dependency and how MNCs produce and maintain cycles of poverty and unsustainable practices through the exploitation of power dynamics within the country.
Targeted placement for people with disabilities in Italy: a perspective from Lombardian companies
Authors: Moscatelli Matteo , Pavesi Nicoletta , Ferrari Chiara 
Published: January 2024

PurposeThe United Nations Convention on the Rights of Persons with Disabilities (2006) recognizes the right of disabled people to access work. Against this legislative backdrop, this study explores the strengths and weaknesses of the Italian system of targeted placement for disabled people, based on Law 68/1999, which delegates to regional authorities the management of the labor market. The examination centers on the perspective of companies, the primary stakeholders in the inclusion of persons with disabilities within organizational structures.Design/methodology/approachThe article discusses the results of focus groups conducted with 28 managers of large, medium and small enterprises in Lombardy (Italy). Qualitative analysis was employed, and the results were structured using a simplified strengths, weaknesses, opportunities and threats (SWOT) analysis, incorporating practical recommendations.FindingsThe analysis leads to practical suggestions to improve the entire targeted placement process at the regional level, from selection and accompaniment to evaluation, such as improving the networking of local stakeholders who deal with the inclusion of disabled people, homogeneity of the procedures in different regions, making all employees aware of diversity management, etc. The territorial network and the welfare environment are particularly important in achieving a successful targeted placement and to promote an inclusive corporate culture.Research limitations/implicationsThis study is not representative of Italy as a whole, as it remains a qualitative investigation focused on a single region.Originality/valueThis contribution accomplishes an in-depth study of the law of labor inclusion of people with disabilities observed from the point of view of companies, which are still usually reluctant to integrate people with disabilities into their organizations or encounter difficulties in doing so.
Does national intellectual capital matter for economic growth in the Asia–Pacific economies?
Authors: Vo Duc Hong , Tran Ngoc Phu 
Published: January 2024

PurposeCountries worldwide aim to improve their comparative advantages by efficiently using scarce resources for economic growth and development. While many studies have been conducted to measure intellectual capital at the firm's level, measuring it at the national level has been under-examined. In addition, while the important role of national intellectual capital in economic growth has been theoretically recognized in literature, this important link has largely been ignored in empirical analyses.Design/methodology/approachThis study uses the newly developed index of national intellectual capital from Vo and Tran's (2022) study to examine its effects on national economic growth in the long run. The dynamic common correlated effects technique and the pooled mean group estimation are used on the sample of 23 economies in the Asia–Pacific region from 2000 to 2020.FindingsFindings from this study confirm the positive and significant contribution of the national intellectual capital to economic growth in the region. The authors also find that, as a feedback effect, economic growth will also enhance and improve the accumulation of national intellectual capital.Practical implicationsThe findings of this paper provide valuable evidence and implications for policymakers in managing and improving national intellectual capital in the Asia–Pacific region.Originality/valueTo the best of the authors’ knowledge, this is the first empirical study to examine the impact of national intellectual capital on economic growth in the long run in the Asia–Pacific economies.
More vocal when satisfied: the effect of need satisfaction on employees' voice to coworkers
Authors: Hu Hong , Chen Liying , Zheng Yuxiang 
Published: January 2024

PurposeThis study aimed to explore the effects of the satisfaction of employees' need for autonomy, relatedness and competence on their voice behavior through the mediation of self-efficacy for voice and perceived risk for voice.Design/methodology/approachThe theoretical model is tested using survey data collected from 209 employees of information technology (IT) firms located in five major cities in China.FindingsThe study found that satisfaction of employees' need for autonomy, relatedness and competence facilitated their self-efficacy for voice and inhibited perceived risk for voice. Self-efficacy for voice was positively related to voice, whereas perceived risk for voice was negatively related to it. Perceived risk for voice hampered self-efficacy for voice.Practical implicationsThe findings indicate that organizations can boost employees' voice behavior by making them feel that they have autonomy in their work, by helping them maintain good relationships with others in the workplace and by enabling their competence in accomplishing their job.Originality/valueThis study highlights that satisfying employees' psychological needs plays a pivotal role in facilitating their voice behavior. The authors provide new insights into the relationship between need satisfaction and voice behavior and into the mediating roles of self-efficacy for voice and perceived risk for voice.
Providers or users of Industry 4.0-based solutions: how does the innovation ecosystem affect a company’s decision to engage in Industry 4.0?
Authors: Boyer James , Kokosy Annemarie 
Published: January 2024

PurposeCompany goals, behaviors and decision-making processes may differ depending on whether a given company decides to engage in the Industry 4.0 (I4.0) paradigm as a user or as a provider of I4.0-based solutions. This paper will consider this question in-depth by focusing on the extent to which the innovation ecosystem (IES) affects these two main strategies.Design/methodology/approachThe authors' study aims to analyze the impact of a regional information and communication technology (ICT) ecosystem on the implementation of I4.0 at the company level by using an original survey of 123 companies that are already engaged in the implementation of I4.0 in the French region of Hauts-de-France and by employing two sets of logit models.FindingsThe authors' empirical study demonstrates the importance of an innovation ecosystem-based strategy for I4.0 technology provision. It reveals that engaging in R&D collaborative projects and developing links and complex relationships with heterogeneous actors within the IES positively affects the likelihood of a given firm deciding to implement I4.0 as a provider of I4.0-based solutions. This does not, however, affect the probability of a firm engaging in the I4.0 paradigm as a user of technologies and solutions.Practical implicationsFrom a policy standpoint, this study could encourage decision-makers to engage with I4.0 development by developing policies targeting the reinforcement of IES at a regional level. This could also help to accelerate the adoption of I4.0 technologies by manufacturing companies and foster the development of I4.0-based solutions through specific company-targeted policies. The authors' study supports the need for manufacturing company managers to evaluate and identify the best technological strategies related to the I4.0 paradigm that meet their specific needs.Originality/valueThe authors' study shows that the decision to engage in the I4.0 paradigm as providers of I4.0-based solutions is more likely to rely on an innovation ecosystem-based strategy, while the decision to engage in the I4.0 paradigm as users of I4.0-based solutions is more likely to rely on the company’s internal strategies, resources and demand-side benefits.
Crowdfunding adoption in emerging economies: insights for entrepreneurs and policymakers
Authors: Kumar Jitender , Rani Manju , Rani Garima , Rani Vinki 
Published: January 2024

PurposeCrowdfunding has emerged as an alternative financing tool and recently gained attention to foster entrepreneurial dynamism and innovation. The current research has identified the determinants impacting the behavioral intentions of entrepreneurs to use crowdfunding for financing their small and medium-sized enterprises (SMEs).Design/methodology/approachThe current article is based on a cross-sectional research design. This research collected the data of 422 owners and managers of SMEs through self-administered questionnaires in the Indian National Capital Region (NCR). The responses were collected from July 17 to October 27, 2022. This article used “partial least squares structural equation modeling” (PLS-SEM) for data analysis.FindingsThis article offered a robust model with a high explanatory value of 66% of behavioral intention and 62.1% variance in crowdfunding use behavior. The finding also highlighted that performance expectancy, social influence, facilitating conditions, trialability and perceived value significantly impact behavioral intention. However, effort expectancy and perceived risk insignificantly influence behavioral intention. Notably, facilitating conditions, trialability and behavioral intention positively impact use behavior.Practical implicationsThe results of this study will bridge the gap in empirical research on crowdfunding adoption, shedding light on why entrepreneurs hesitate to adopt crowdfunding for financing. Moreover, these results will offer strategic insights for crowdfunding managers and policymakers, aiding them in making informed decisions.Originality/valueTo the best of the authors' knowledge, this pioneering study built the theoretical framework using three credible technology determinant models. The authors examined crowdfunding-specific contextual factors to improve understanding of the positive effect of technological orientation. This addition assists in strategically arranging entrepreneurs' fundraising conversations more efficiently.
The emergence of preprints: comparing publishing behaviour in the Global South and the Global North
Authors: Biesenbender Kristin , Smirnova Nina , Mayr Philipp , Peters Isabella 
Published: January 2024

PurposeThe recent proliferation of preprints could be a way for researchers worldwide to increase the availability and visibility of their research findings. Against the background of rising publication costs caused by the increasing prevalence of article processing fees, the search for other ways to publish research results besides traditional journal publication may increase. This could be especially true for lower-income countries.Design/methodology/approachTherefore, the authors are interested in the experiences and attitudes towards posting and using preprints in the Global South as opposed to the Global North. To explore whether motivations and concerns about posting preprints differ, the authors adopted a mixed-methods approach, combining a quantitative survey of researchers with focus group interviews.FindingsThe authors found that respondents from the Global South were more likely to agree to adhere to policies and to emphasise that mandates could change publishing behaviour towards open access. They were also more likely to agree posting preprints has a positive impact. Respondents from the Global South and the Global North emphasised the importance of peer-reviewed research for career advancement.Originality/valueThe study has identified a wide range of experiences with and attitudes towards posting preprints among researchers in the Global South and the Global North. To the authors' knowledge, this has hardly been studied before, which is also because preprints only have emerged lately in many disciplines and countries.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-04-2023-0181
Epidermal turnover and iron metabolism in senile lentigo
Authors: Odawara Mikiko , Mezaki Minori , Yoshimura Tomohisa , Takaoka Akiko , Oda Fumino , Saeki Hidehisa , Funasaka Yoko 
Published: January 2024

AbstractSenile lentigo (SL) is a pigmentary disorder associated with disrupted epidermal turnover. Trace minerals in the skin are known to regulate keratinocyte proliferation and differentiation. To clarify the role of iron in SL, we compared the expression of molecules related to iron metabolism between SL lesion (lesion) and the surrounding normal skin (nonlesion). Our results revealed that proteins involved in iron uptake and utilization such as transferrin receptor 1, iron regulatory protein 1, mitoferrin 1, and divalent metal transporter 1 were expressed in the lower epidermis in the nonlesion, while expression of them was also observed in the upper epidermis in the lesion. Ferroportin (FPN), involved in iron export, was expressed in the upper epidermis in the nonlesion, but was only scarcely expressed in the upper epidermis in the lesion. Hepcidin, which promotes FPN degradation, was expressed in the lower epidermis in the nonlesion; however, its expression was also observed in the upper epidermis in the lesion. These changes in the expression of molecules involved in iron uptake/export/utilization might reflect the altered iron utilization state in SL, resulting in disruption of keratinocyte differentiation and disturbing epidermal turnover. Our results suggest that the metabolism of iron in keratinocytes in SL differs from that in the normal epidermis, and these changes could be associated with the abnormal epidermal turnover and decreased melanin excretion in SL.