bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validating the Dutch Eating Behavior Questionnaire for Children (DEBQ-C) among Korean children and adolescents with high weight
Authors: Kim Na Young , Suh Sooyeon , Kim Jieun , Son Kumhee , Woo Sarah , Kim Jia , Park Kyung Hee , Lim Hyunjung 
Published: October 2023

Abstract
Background
Using reliable measurement tools is becoming increasingly important as the prevalence of obesity among children increases in Korea. The Dutch Eating Behavior Questionnaire for Children (DEBQ-C) measures three eating behaviors associated with overeating. This study aims to validate the DEBQ-C for use among Korean children and adolescents with high body weight. It examines the psychometric features of the Korean translation of the DEBQ-C and investigates the relationship between the subscale scores of the DEBQ-C and the weight status of participants (categorized into overweight, obese, and morbidly obese).

Methods
A total of 233 children and adolescents (mean age: 11.4 ± 1.6 years) completed the questionnaire. The study verified the factor structure of the DEBQ-C using confirmatory factor analysis (CFA) and estimated its internal consistency with Cronbach’s alpha. For convergent validity, it employed Pearson’s correlation coefficient to assess relationships between the three eating behaviors of the DEBQ-C and the number of food addiction symptoms of the Yale Food Addiction Scale for Children (YFAS-C). Lastly, it examined the relationship between DEBQ-C scores and weight status via multinomial logistic regression analysis.

Results
The three-factor model demonstrated goodness-of-fit (χ2 = 253, df = 167, χ2/df = 1.515, p < 0.001, CFI = 0.944; TLI = 0.937; RMSEA = 0.047). The internal consistency of the three eating behaviors was also satisfactory (Cronbach’s alpha = 0.707–0.890). The emotional and external eating subscales of the DEBQ-C were positively correlated with the number of symptoms of food addiction of the YFAS-C. Emotional (OR: 2.008; 95% CI 1.973–2.043) and external (OR: 2.074; 95% CI 2.029–2.119) eating were positively associated with obesity status.

Conclusion
The results suggest that the Korean version of the DEBQ-C is suitable for the examination of problematic eating behaviors in Korean children and adolescents with high body weight.
Investigating the association of informal digital learning of English with EFL learners’ intercultural competence and willingness to communicate: a SEM study
Authors: Rezai Afsheen 
Published: October 2023

AbstractInformal Digital Learning of English (IDLE), such as watching online videos, playing games, or chatting with English speakers beyond the classroom, has received increasing attention over recent years as a potential source of intercultural competence (IC) and second language willingness to communicate (L2 WTC) development among English as a Foreign Language (EFL) learners. However, little is known about how IDLE influences IC and L2 WTC among EFL learners, who face various challenges and opportunities in learning and using English in Iran. Thus, this research examined the relationship between IDLE and IC and L2 WTC in Iranian EFL learners. For this purpose, the study was conducted with the participation of 325 EFL learners from a language institute in Arak City, Iran, who were selected using convenience sampling. The participants completed the Digital Informal Learning Scale, the Intercultural Competence Scale, and the Willingness to Communicate Questionnaire. The results of the structural equation modeling revealed that IDLE had a significant positive association with both IC and L2 WTC. Further, the results indicated that IDLE dimensions, such as cognitive, meta-cognitive, social, and motivational aspects were significantly related to IC and L2 WTC. The findings approve that promoting IDLE among Iranian EFL learners could enhance their intercultural awareness and communication skills.
Factors predicting mental health in youth during the first COVID-19 lockdown in Spain
Authors: Vicario-Molina Isabel , Ortega Eva González , González Ruth Pinedo , Picos Andrés Palacios 
Published: October 2023

Abstract
Background
The first COVID-19 lockdown decreed in Spain by the government resulted in a significant disruption in the daily lives of youth that may have affected their mental health. The aim of this study was to identify factors that influenced youth mental health during this period. Methods: Between March and May 2020, a sample of 1205 youths (age range 18–24 years) from across Spain completed a questionnaire that assessed sociodemographic, mental health, loneliness, coping with humour and healthy habits. Data were analysed using Structural Equation Modelling.

Results
The proposed model showed good fit values, and significant variables explained 37% of mental health. loneliness, coping humour, healthy and unhealthy habits, and gender significantly predicted youth mental health.

Conclusions
The consequences of the pandemic and confinement derived from COVID-19 seemed to be especially severe for youth, increasing their mental health vulnerability. It is recommended that evaluating the long-term effects of confinement on this population, the mental health needs they may have and the support resources that would help meet them in situations of isolation, paying special attention to females.
A multi-manifold learning based instance weighting and under-sampling for imbalanced data classification problems
Authors: Feizi Tayyebe , Moattar Mohammad Hossein , Tabatabaee Hamid 
Published: October 2023

AbstractUnder-sampling is a technique to overcome imbalanced class problem, however, selecting the instances to be dropped and measuring their informativeness is an important concern. This paper tries to bring up a new point of view in this regard and exploit the structure of data to decide on the importance of the data points. For this purpose, a multi-manifold learning approach is proposed. Manifolds represent the underlying structures of data and can help extract the latent space for data distribution. However, there is no evidence that we can rely on a single manifold to extract the local neighborhood of the dataset. Therefore, this paper proposes an ensemble of manifold learning approaches and evaluates each manifold based on an information loss-based heuristic. Having computed the optimality score of each manifold, the centrality and marginality degrees of samples are computed on the manifolds and weighted by the corresponding score. A gradual elimination approach is proposed, which tries to balance the classes while avoiding a drop in the F measure on the validation dataset. The proposed method is evaluated on 22 imbalanced datasets from the KEEL and UCI repositories with different classification measures. The results of the experiments demonstrate that the proposed approach is more effective than other similar approaches and is far better than the previous approaches, especially when the imbalance ratio is very high.
Preoperative demographics and laboratory markers may be associated with early dislocation after total hip arthroplasty
Authors: Lung Brandon E. , Donnelly Megan R. , Callan Kylie , McLellan Maddison , Taka Taha , Stitzlein Russell N. , McMaster William C. , So David H. , Yang Steven 
Published: October 2023

AbstractPurposeThe purpose of this study was to identify modifiable medical comorbidities, laboratory markers and flaws in perioperative management that increase the risk of acute dislocation in total hip arthroplasty (THA) patients.MethodsAll THA with primary indications of osteoarthritis from 2007 to 2020 were queried from the National Surgical Quality Improvement Program (NSQIP) database. Demographic data, preoperative laboratory values, recorded past medical history, operative details as well as outcome and complication information were collected. The study population was divided into two cohorts: non‐dislocation and dislocation patients. Statistics were performed to compare the characteristics of both cohorts and to identify risk factors for prosthetic dislocation (α < 0.05).Results275,107 patients underwent primary THA in 2007 to 2020, of which 1,258 (0.5%) patients experienced a prosthetic hip dislocation. Demographics between non‐dislocation and dislocation cohorts varied significantly in that dislocation patients were more likely to be female, older, with lower body mass index and a more extensive past medical history (all p < 0.05). Moreover, hypoalbuminemia and moderate/severe anemia were associated with increased risk of dislocation in a multivariate model (all p < 0.05). Finally, use of general anesthesia, longer operative time, and longer length of hospital stay correlated with greater risk of prosthetic dislocation (all p < 0.05).ConclusionsElderly female patients and patients with certain abnormal preoperative laboratory values are at risk for sustaining acute dislocations after index THA. Careful interdisciplinary planning and medical optimization should be considered in high‐risk patients as dislocations significantly increase the risk of sepsis, cerebral vascular accident, and blood transfusions on readmission.
Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study
Authors: Motevalizadeh Ehsan , Díaz-López Andrés , Martín Francisco , Basora Josep , Arija Victoria 
Published: October 2023

Abstract

Context
Little is known about whether parity is associated with elevated early-pregnancy insulin resistance (IR), or whether overweight/obesity contributes to increasing the possible effect.

Objective
We determined the associations between parity and glucose metabolism parameters in the first trimester of pregnancy in a Mediterranean pregnant population, and whether these associations are affected by overweight/obesity.

Methods
A cross-sectional study was conducted of 264 healthy pregnant women from the ECLIPSES study who were recruited at 12 weeks of gestation. At baseline, details on socioeconomic status, obstetric history (including parity, ie, number of births), lifestyle factors, anthropometry, and blood samples were collected. Fasting serum glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index were assessed in the first trimester. Elevated IR was defined as the upper HOMA-IR tertile (≥1.58). Multivariable linear regression and Cox regression model with constant time were performed.

Results
Parity ranged from 0 to 4. After multivariable adjustment, the insulin levels (β [% change]: 20.92; 95% CI, 4.08-37.71) and HOMA-IR index (β [% change]: 19.72; 95% CI, 2.43-40.49) were positively associated with parity. Additionally, multiparous women, as compared to nulliparous, were more likely to have higher HOMA-IR levels (primiparous [1 birth], β [% change[: 16.88; 95% CI, −1.00 to 37.99; multiparous [≥2 births), β [% change]: 32.18; 95% CI, 3.56-68.71), and an increased relative risk (RR) of an elevated IR (primiparous [1 birth], RR: 1.55; 95% CI, 1.03-2.36; multiparous (≥2 births), RR: 1.72; 95% CI, 1.05-2.83). The combination of multiparity and overweight/obesity conferred a 3.04-fold increase in the RR of elevated IR, which increased proportionally to the number of parities.

Conclusion
This study demonstrates that parity may have a negative effect on early-pregnancy IR and that maternal overweight/obesity appears to further aggravate this relationship.
FRI073 Use Of Obesogenic Medications Among Patients With Type 2 Diabetes In The Dominican Republic
Authors: Agramonte Villar Scarlet P , Gil Vega Carlos R , Reynoso Ortiz Jose M , Sosa Pinedo Lisbeth R , Vasquez Morel Roberto A , Polanco Santos Carmen M , San Martin Vicente T 
Published: October 2023

Abstract
Disclosure: S.P. Agramonte Villar: None. C.R. Gil Vega: None. J.M. Reynoso Ortiz: None. L.R. Sosa Pinedo: None. R.A. Vasquez Morel: None. C.M. Polanco Santos: None. V.T. San Martin: None.
Background: Obesity is a major risk factor for the development and progression of type 2 diabetes mellitus (T2DM). Among the modifiable factors that can promote weight gain is the use of obesogenic medications (OM). The prevalence of the use of OM in patients with T2DM in the Dominican Republic (DR) is unknown. Objective: This study aimed to evaluate the use of OM among patients with T2DM in the DR. Methods: Cross-sectional study based on patient surveys and anthropometric measurements obtained in an outpatient primary care clinic in Santo Domingo, DR between October 2022 and November 2022. Patients aged ≥18 years with a known diagnosis of T2DM were included. Weight status was categorized according to body mass index (BMI). OM were defined according to the study by Hales et al1. Results: A total of 220 patients were surveyed and analyzed. Overall, 57.7% (127/220) of the patients reported a current use of one or more OM; 50.0% (110/220) were using one OM, 6.4% (14/220) were using two OM, and 1.3% (3/220) were using three OM. Among the patients using at least one OM, 45.7% (58/127) had overweight (BMI 25.0-29.9 kg/m2) and 40.9% (52/127) had obesity (BMI &gt;30 kg/m2). The most frequently used antidiabetes OM was insulin [any type] (n=83), followed by glyburide (n=17) and glimepiride (n=13). The most commonly used non-antidiabetes OM was metoprolol (n=8), followed by atenolol (n=6) and pregabalin (n=6). Conclusion: More than half of the patients with T2DM were using at least one OM. The use of OM can contribute to weight gain and may hinder weight loss efforts in these patients, thus potentially negatively impacting the management of their underlying chronic disease. Reference: 1. Hales CM et al. Use of prescription medications associated with weight gain among US adults, 1999-2018: A nationally representative survey. Obesity (Silver Spring). 2022;30:229-239.
Presentation: Friday, June 16, 2023
SAT152 Retrospective Analysis Of HbA1c In Patients Diagnosed With Pancreatic Insulinoma Prior To- And After Surgical Excision
Authors: Lawless Sarah Jean , McGrath Aisling , Campbell Ruth , O'Keeffe Derek , Bell Marcia J 
Published: October 2023

Abstract
Disclosure: S.J. Lawless: None. A. McGrath: None. R. Campbell: None. D. O'Keeffe: None. M.J. Bell: None.
Insulinomas are rare pancreatic tumours characterised by episodes of hyperinsulinaemic hypoglycaemia. Patients may develop secondary diabetes following surgical intervention for insulinoma. Glycated haemoglobin (HbA1c) is a reliable bio-marker for the diagnosis and prognosis of diabetes. HbA1c is a useful surrogate marker for insulinoma (1). A retrospective analysis of patients diagnosed with insulinoma and attending our service in Galway University Hospital (GUH) was performed. Data was collected using the electronic patient correspondence system to gather information from clinic letters, hospital and GP laboratory results were accessed on the Evolve laboratory system. Diagnostic criteria employed a 72-hour fast with plasma glucose levels of ≤2.2 mmol/L, with a corresponding insulin level ≥18 pmol/L and a c-peptide of &lt;200 pmol/l. We analysed their HbA1c at initial presentation and longitudinally following treatment. There are currently six patients carrying a diagnosis of insulinoma attending our service. All of these patients have had surgical intervention. At diagnosis four of the six patients had a HbA1c taken. One patient was diagnosed prior to HbA1c being routinely available and another patient had initial investigations and management elsewhere. The average HbA1c at time of diagnosis was 27.75 mmol/mol (n=4) (reference range 20 to 42 mmol/mol). All insulinoma patients have their HbA1c monitored yearly as part of ongoing follow-up. HbA1c trends upwards with an average HbA1c 18-24 months post surgical excision of 36.25 mmol/mol (n=4). There is a tendency of increased HbA1c post-operatively with a mean increase in HbA1c of 8.5 mmol/mol over 18-24 months. Three of our six patients have developed diabetes on extended follow-up. The average time to diagnosis post-surgical resection was 5.5 years (n=3). HbA1c is a useful tool for monitoring for secondary diabetes post pancreatic surgery. While admitting our number of patients is low, it is interesting to observe the difference in HbA1c pre- and post-operatively in patients with insulinoma. 1.Vaidakis, Dennis, et al. "Pancreatic insulinoma: current issues and trends." Hepatobiliary & pancreatic diseases international: HBPD INT 9.3 (2010): 234-241.
Presentation: Saturday, June 17, 2023
SAT153 A Case Of Hypoglycemia-induced Chest Pain Secondary To Adult Nesidioblastosis: A Case Report
Authors: Medina Espitia Oscar Leonardo , Altare Alejandro Quintero , Clavijo Veronica A , Martínez Delgado Laura C 
Published: October 2023

Abstract
Disclosure: O.L. Medina Espitia: None. A. Quintero Altare: None. V.A. Clavijo: None. L.C. Martínez Delgado: None.
The report of the present case in the medical literature is important in itself because of the infrequency of Nesidioblastosis. Additionally, it allows us to show unusual forms of presentation such as chest pain, and dynamic electrocardiographic changes in the ST segment with negative troponin, which coincide with episodes of hypoglycemia. At admission, the patient consulted the emergency department for a clinical presentation consisting of progressive retrosternal chest pain radiating to the left cervical region associated with dyspnea for medium exertion, palpitations, and dysautonomic symptoms, given by nausea. Due to episodes of chest pain, a coronary arteriography had been performed six months before admission without evidence of obstructive lesions. During hospitalization, episodes of hypoglycemia were observed. Remarkably, it was possible to document Dynamic ST changes in all EKG leads during episodes of hypoglycemia, as shown in Figure 1. Among the differential diagnoses, hypoglycemia secondary to adrenal or thyroid dysfunction was considered a first possibility, which was ruled out in the presence of normal paraclinical tests and medications that could generate hypoglycemia (negative sulfonylurea tests) were ruled out. A fasting test was performed with results showing endogenous hyperinsulinemic hyperinsulinemia with levels of insulin in 35.5 mg/dL, C-peptide 9.34 ng/dL and blood glucose 34 mm/dL. MRI of the abdomen without lesions. Due to a history of gastric bypass, endoscopic ultrasonography was not performed, therefore pancreatic calcium stimulation test was performed with evidence of a significant delta over the territory of the splenic artery. A distal pancreatectomy was obtained. Pathology report with findings suggestive of Nesidioblastosis (Figure 2.). There was a complete resolution of episodes of hypoglycemia and chest pain for two weeks. The recurrence of hypoglycemia episodes led to ambulatory treatment, with diazoxide with complete resolution of events.
Presentation: Saturday, June 17, 2023
SAT654 Regulation Of The Melanocortin-4 Receptor (mc4r) By Attractin Like Protein 1 (alp1)
Authors: Buscaglia Paul , Sebag Julien 
Published: October 2023

Abstract
Disclosure: P. Buscaglia: None. J. Sebag: None.
The Melanocortin-4 Receptor (MC4R) plays a central role in the regulation of energy homeostasis. Mutations in MC4R are responsible for up to 6% of early onset obesity in humans and deletion of MC4R in mice results in severe obesity due to hyperphagia. MC4R is a GPCR expressed in different region of the brains including the paraventricular nucleus of the hypothalamus. Stimulation of MC4R by its agonist αMSH and inhibition by its endogenous inverse agonist AGRP result in inhibition or stimulation of food intake respectively. MC4R is known to interact with two single transmembrane proteins, the Melanocortin Receptor Accessory Protein 2 (MRAP2) and Attractin Like Protein 1 (ALP1). Whereas MRAP2 has been shown to promote MC4R signaling in vitro and in vivo, the pharmacological and physiological relevance of ALP1 for MC4R signaling and actions is not known. To determine if ALP1 alters MC4R signaling, we measured αMSH-stimulated cAMP production in cells transfected with MC4R alone or with either ALP1 or MRAP2. We found that ALP1 increases MC4R signaling to a larger extent than MRAP2. We also showed that ALP1 inhibits β-arrestin recruitment to MC4R, thus likely preventing desensitization of the receptor. To assess the physiological importance of ALP1, we generated an ALP1Flox mouse and bred it to MC4RCRE mice. Deletion of ALP1 in MC4R neurons resulted in increased body weight compared to MC4RCRE control on standard diet. This increase in body weight was further exacerbated when animals were fed a high fat diet. In conclusion our results suggest that ALP1 regulates MC4R signaling and that deletion of ALP1 from MC4R neurons causes weight gain that may be due to decreased MC4R activity.
Presentation: Saturday, June 17, 2023
FRI277 Temporal Coordination Of Female Reproductive Axis Activity By Vasoactive Intestinal Polypeptide (VIP) Expressing Cells In The Suprachiasmatic Nucleus
Authors: Phumsatitpong Chayarndorn , Bever Savannah R , Hu Stacy L , Ambrose Mary C , Kriegsfeld Lance J 
Published: October 2023

Abstract
Disclosure: C. Phumsatitpong: None. S.R. Bever: None. S.L. Hu: None. M.C. Ambrose: None. L.J. Kriegsfeld: None.
Circadian rhythms orchestrated by a master clock in the suprachiasmatic nucleus (SCN) are essential for ovulation in spontaneously-ovulating rodents. SCN signaling integrates with estradiol positive feedback to generate the preovulatory luteinizing hormone (LH) surge. Additionally, subordinate clocks in reproductively-relevant SCN targets temporally gate responsiveness to upstream signaling to coordinate ovulation with the active time of day. We have previously shown that the SCN communicates directly to kisspeptin (Kp) and RFamide-related peptide-3 (RFRP-3) neurons to temporally balance key stimulatory and inhibitory input to GnRH neurons required for LH surge generation. Because VIP-expressing neurons in the SCN have been implicated in the LH surge, we employed a cell-specific chemogenetic approach to determine the functional role of this cell phenotype in female reproductive axis regulation required for surge generation. We hypothesized that temporal gating by subordinate cellular clocks will prevent morning stimulation of VIP-expressing cells from increasing Kp and GnRH, and decreasing RFRP-3, cellular activity. In the afternoon, we expected inhibition of VIP-expressing cells to decrease Kp and GnRH, and increase RFRP-3, cellular activity. Specifically, female VIP-Cre mice were stereotaxically injected with either AAV-hM3Dq or hM4Di to express activating (3Dq) or inhibitory (4Di) DREADDs in VIP-expressing SCN cells. Following recovery, mice were injected clozapine n-oxide (CNO) either in the morning, prior to the LH surge (3Dq experiment), or the afternoon, around the time of the LH surge (4Di experiment). Brains were collected to examine neuronal activation in Kp, GnRH, and RFRP-3 neurons using FOS immunofluorescence as a marker. Morning stimulation of SCN VIP neurons decreased RFRP-3 neuronal activation, whereas Kp and GnRH neurons were unaffected at this time, suggesting a temporal gating mechanism at GnRH and/or Kp cells prevents premature ovulation. In contrast, afternoon inhibition of SCN VIP-expressing neurons led to an increase in neuronal activation in RFRP-3 neurons concomitant with a decrease in GnRH and Kp neurons, suggesting that VIP stimulation is required to remove RFRP-3 inhibition on the GnRH and Kp systems. We confirmed this possibility by localizing afternoon injections of CNO to RFRP-3 cells, which led to comparable decreases in GnRH and Kp cellular activity. These data indicate the importance of SCN VIP neurons in the temporally coordinated disinhibition of RFRP-3 neuronal activity required for stimulation of GnRH and Kp neurons around the time of LH surge. Supported by NIH Grant HD-050470.
Presentation: Friday, June 16, 2023