bluuebunny/crossref_metadata_2025_split huggingface dataset:
The test-induced warm-up effect on hamstring flexibility tests
Authors: Lim Wootaek 
Published: November 2023

Background: Although the effect of active warm-up (WU) on acute flexibility enhancement is well documented, the test-induced WU effect in muscle length test has not been widely studied. Objective: This study aimed to verify the test-induced WU effect on hamstring flexibility tests. Methods: The active knee extension (AKE) was performed using the right leg, whereas the straight leg raise (SLR) was performed using the left leg. Ten trials of AKE or SLR were performed: two as the pre-intervention trials (Pre); six as the WU intervention; and another two trials as the post-intervention (Post). During WU, subjects in the WO-Hold group performed six trials of the AKE or SLR without hold, and those in the W-Hold group performed six trials of the AKE or SLR with a 5[Formula: see text]s hold. Results: A significant difference was noted between Pre-AKE and Post-AKE, and between Pre-SLR and Post-SLR, respectively, in both the groups. The effect of WU is clear when performing consecutive AKE or SLR without any additional hold. Conclusion: Practitioners should be cautious in interpreting the testing result to avoid overestimation of the treatment effect since the test itself may induce substantial WU effect to the target tissues.
Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery
Authors: Hajjar Roy , Oliero Manon , Fragoso Gabriela , Ajayi Ayodeji Samuel , Alaoui Ahmed Amine , Vennin Rendos Hervé , Calvé Annie , Cuisiniere Thibault , Gerkins Claire , Thérien Sophie , Taleb Nassima , Dagbert François , Sebajang Herawaty , Loungnarath Rasmy , Schwenter Frank , Ratelle Richard , Wassef Ramses , De Broux Eric , Richard Carole , Santos Manuela M. 
Published: November 2023

Abstract

Purpose:
Anastomotic leak (AL) is a major complication in colorectal cancer surgery and consists of the leakage of intestinal content through a poorly healed colonic wound. Colorectal cancer recurrence after surgery is a major determinant of survival. We hypothesize that AL may allow cancer cells to escape the gut and lead to cancer recurrence and that improving anastomotic healing may prevent local implantation and metastatic dissemination of cancer cells.

Experimental Design:
We investigated the association between AL and postoperative outcomes in patients with colorectal cancer. Using mouse models of poor anastomotic healing, we assessed the processes of local implantation and dissemination of cancer cells. The effect of dietary supplementation with inulin and 5-aminosalicylate (5-ASA), which activate PPAR-γ in the gut, on local anastomotic tumors was assessed in mice undergoing colonic surgery. Inulin and 5-ASA were also assessed in a mouse model of liver metastasis.

Results:
Patients experiencing AL displayed lower overall and oncologic survival than non-AL patients. Poor anastomotic healing in mice led to larger anastomotic and peritoneal tumors. The microbiota of patients with AL displays a lower capacity to activate the antineoplastic PPAR-γ in the gut. Modulation of gut microbiota using dietary inulin and 5-ASA reinforced the gut barrier and prevented anastomotic tumors and metastatic spread in mice.

Conclusions:
Our findings reinforce the hypothesis that preventing AL is paramount to improving oncologic outcomes after colorectal cancer surgery. Furthermore, they pave the way toward dietary targeting of PPAR-γ as a novel way to enhance healing and diminish cancer recurrence.
Preserved Corticospinal Tract Revealed by Acute Perfusion Imaging Relates to Better Outcome After Thrombectomy in Stroke
Authors: Koch Philipp J. , Rudolf Linda F. , Schramm Peter , Frontzkowski Lukas , Marburg Maria , Matthis Christine , Schacht Hannes , Fiehler Jens , Thomalla Götz , Hummel Friedhelm C. , Neumann Alexander , Münte Thomas F. , Royl Georg , Machner Björn , Schulz Robert 
Published: November 2023

BACKGROUND:
The indication for mechanical thrombectomy (MT) in stroke patients with large vessel occlusion has been constantly expanded over the past years. Despite remarkable treatment effects at the group level in clinical trials, many patients remain severely disabled even after successful recanalization. A better understanding of this outcome variability will help to improve clinical decision-making on MT in the acute stage. Here, we test whether current outcome models can be refined by integrating information on the preservation of the corticospinal tract as a functionally crucial white matter tract derived from acute perfusion imaging.

METHODS:
We retrospectively analyzed 162 patients with stroke and large vessel occlusion of the anterior circulation who were admitted to the University Medical Center Lübeck between 2014 and 2020 and underwent MT. The ischemic core was defined as fully automatized based on the acute computed tomography perfusion with cerebral blood volume data using outlier detection and clustering algorithms. Normative whole-brain structural connectivity data were used to infer whether the corticospinal tract was affected by the ischemic core or preserved. Ordinal logistic regression models were used to correlate this information with the modified Rankin Scale after 90 days.

RESULTS:
The preservation of the corticospinal tract was associated with a reduced risk of a worse functional outcome in large vessel occlusion–stroke patients undergoing MT, with an odds ratio of 0.28 (95% CI, 0.15–0.53). This association was still significant after adjusting for multiple confounding covariables, such as age, lesion load, initial symptom severity, sex, stroke side, and recanalization status.

CONCLUSIONS:
A preinterventional computed tomography perfusion–based surrogate of corticospinal tract preservation or disconnectivity is strongly associated with functional outcomes after MT. If validated in independent samples this concept could serve as a novel tool to improve current outcome models to better understand intersubject variability after MT in large vessel occlusion stroke.
Learning Cognitive Flexibility: Neural Substrates of Adapting Switch-Readiness to Time-varying Demands
Authors: Sali Anthony W. , Bejjani Christina , Egner Tobias 
Published: November 2023

Abstract
An individual's readiness to switch tasks (cognitive flexibility) varies over time, in part, as the result of reinforcement learning based on the statistical structure of the world around them. Consequently, the behavioral cost associated with task-switching is smaller in contexts where switching is frequent than where it is rare, but the underlying brain mechanisms of this adaptation in cognitive flexibility are not well understood. Here, we manipulated the likelihood of switches across blocks of trials in a classic cued task-switching paradigm while participants underwent fMRI. As anticipated, behavioral switch costs decreased as the probability of switching increased, and neural switch costs were observed in lateral and medial frontoparietal cortex. To study moment-by-moment adjustments in cognitive flexibility at the neural level, we first fitted the behavioral RT data with reinforcement learning algorithms and then used the resulting trial-wise prediction error estimate as a regressor in a model-based fMRI analysis. The results revealed that lateral frontal and parietal cortex activity scaled positively with unsigned switch prediction error and that there were no brain regions encoding signed (i.e., switch- or repeat-specific) prediction error. Taken together, this study documents that adjustments in cognitive flexibility to time-varying switch demands are mediated by frontoparietal cortex tracking the likelihood of forthcoming task switches.
Can Authorship Representation Learning Capture Stylistic Features?
Authors: Wang Andrew , Aggazzotti Cristina , Kotula Rebecca , Soto Rafael Rivera , Bishop Marcus , Andrews Nicholas 
Published: November 2023

Abstract
Automatically disentangling an author’s style from the content of their writing is a longstanding and possibly insurmountable problem in computational linguistics. At the same time, the availability of large text corpora furnished with author labels has recently enabled learning authorship representations in a purely data-driven manner for authorship attribution, a task that ostensibly depends to a greater extent on encoding writing style than encoding content. However, success on this surrogate task does not ensure that such representations capture writing style since authorship could also be correlated with other latent variables, such as topic. In an effort to better understand the nature of the information these representations convey, and specifically to validate the hypothesis that they chiefly encode writing style, we systematically probe these representations through a series of targeted experiments. The results of these experiments suggest that representations learned for the surrogate authorship prediction task are indeed sensitive to writing style. As a consequence, authorship representations may be expected to be robust to certain kinds of data shift, such as topic drift over time. Additionally, our findings may open the door to downstream applications that require stylistic representations, such as style transfer.
Optimal Transport Posterior Alignment for Cross-lingual Semantic Parsing
Authors: Sherborne Tom , Hosking Tom , Lapata Mirella 
Published: November 2023

Abstract
Cross-lingual semantic parsing transfers parsing capability from a high-resource language (e.g., English) to low-resource languages with scarce training data. Previous work has primarily considered silver-standard data augmentation or zero-shot methods; exploiting few-shot gold data is comparatively unexplored. We propose a new approach to cross-lingual semantic parsing by explicitly minimizing cross-lingual divergence between probabilistic latent variables using Optimal Transport. We demonstrate how this direct guidance improves parsing from natural languages using fewer examples and less training. We evaluate our method on two datasets, MTOP and MultiATIS++SQL, establishing state-of-the-art results under a few-shot cross-lingual regime. Ablation studies further reveal that our method improves performance even without parallel input translations. In addition, we show that our model better captures cross-lingual structure in the latent space to improve semantic representation similarity.1
The effect of dual-task training on cognitive ability, physical function, and dual-task performance in people with dementia or mild cognitive impairment: A systematic review and meta-analysis
Authors: Yu Dan , LI Xun , He Shutang , Zhu Huina , Lam Freddy Man Hin , Pang Marco Yiu Chung 
Published: November 2023

Objective To summarize the effect of dual-task training on cognitive, physical function, and dual-task performance in people with mild cognitive impairment or dementia. Data sources Embase, PEDro, PsycINFO, PubMed, CINAHL, The Cochrane Library, and a forward search conducted via Web of Science have been searched from inception to July 2023. Review methods Good-quality randomized controlled trials compared dual-task training with no/placebo intervention or single-task training among people with a primary diagnosis of mild cognitive impairment or dementia were included. The PEDro scale was used to evaluate the methodological quality of individual studies. The Grading of Recommendations, Assessment, Development and Evaluations system was adopted to appraise the quality of evidence for each outcome. Results Eighteen trials (1325 participants) were included, and 17 provided data for meta-analysis. Comparing with no intervention, dual-task training led to significant improvements on attention (mean difference (MD) = −20.66, 95%CI [−39.42, −1.90]), functional mobility (MD = −2.73; 95%CI [−3.98, −1.49]). Compared with single-task training, dual-task training had greater effects on overall cognitive function (standardized mean difference (SMD) = 0.29, 95%CI [0.09, 0.49]), balance (SMD = 0.78, 95%CI [0.40, 1.15]) and functional mobility (MD = −1.17; 95%CI [−1.77, −0.58]). Its effect on dual-task performance remains inconclusive due to the inconsistent results reported. Conclusion Low- to moderate-quality evidence supports that dual-task training has beneficial effects on cognitive function and physical function in individuals with dementia or mild cognitive impairment. The optimal training protocol of dual-task training on cognitive and physical functions, and dual-task performance remains uncertain. Well-designed, randomized studies with large enough sample sizes are warranted.
Age Changes in Religious Service Attendance in Mexican American Older Adults: A Growth Curve Analysis
Authors: Stroope Samuel , Kroeger Rhiannon A. 
Published: November 2023

Objectives This study examines age patterns in religious attendance in older Mexican Americans. Previous research has focused on majority-white samples, limiting generalizability to other groups. Research in ethnic minority populations is needed. Methods We descriptively analyze Hispanic Established Population for the Epidemiological Study of the Elderly (Hispanic EPESE) data and estimate a mixed effects linear growth curve model to assess the relationship between age and religious attendance. Results: Descriptive results reveal an inverse U-shaped pattern of religious attendance. Results from the growth curve model indicate rising religious attendance after age 65 and a decline after the mid-70s, an earlier decline compared to majority-white studies. Discussion: These findings have implications for individual well-being, the functioning of religious congregations, and for understanding the patterning of a salient form of social participation among older adults. Further research is needed to explore the underlying mechanisms and to examine religious attendance patterns in understudied populations.
Endovascular and Surgical Venous Arterialization for No-Option Patients With Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-Analysis
Authors: Ucci Alessandro , Perini Paolo , Freyrie Antonio , Schreve Michiel A. , Ünlü Çağdaş , Huizing Eline , van den Heuvel Daniel A. , Kum Steven , Shishehbor Mehdi H. , Ferraresi Roberto 
Published: November 2023

Background: Chronic limb-threatening ischemia (CLTI) is known for its high rates of major amputation and mortality. Conventional revascularization techniques often fail in CLTI patients due to the heavily diseased arteries. Foot vein arterialization (FVA) has been proposed as an alternative technique to provide arterial blood to the foot by using the disease-free venous bed. Objectives: This systematic review and meta-analysis aimed to determine outcomes of surgical FVA (sFVA) and percutaneous FVA (pFVA) at 6 and 12 months post-procedure. Data sources: PubMed, Scopus, Web of Science, and the Cochrane Library databases were searched to identify papers reporting clinical outcomes of sFVA and pFVA published between January 1966 and March 2023. Methods: Databases were searched for eligible studies. A meta-analysis was performed to evaluate the limb salvage rate, overall survival rate, and wound healing rate at 6 and 12 months. Results: A total of 27 studies were included, with 753 patients and 793 limbs. Of the included studies, 16 analyzed the sFVA technique and 11 the pFVA technique. Of the included patients, 86.3% were Rutherford 5/6 in the sFVA group versus 98.4% in the pFVA group. The pooled limb salvage rate at 6 and 12 months was 78.1% and 74.1% in the sFVA group and 81.7% and 78.6% in the pFVA group, respectively. Wound healing rates were not reported in the sFVA group. In the pFVA group, the pooled wound healing rates were 48.1% and 64.5% at 6 and 12 months, respectively. Conclusion: This study showed promising results after FVA among a large population of CLTI patients. In high-risk patients, pFVA is a feasible option with favorable limb salvage and wound healing rates.
Quality of patient- and proxy-reported outcomes for children with impairment of the lower extremity: A systematic review using the COnsensus-based Standards for selection of health Measurement INstruments methodology
Authors: Saris Tim FF , Kalle JP Ruben , Sierevelt Inger N , Eygendaal Denise , van Bergen Christiaan JA 
Published: November 2023

Background: Patient-reported outcome measures have become crucial in the clinical evaluation of patients. Appropriate selection, in a young population, of the instrument is vital to providing evidence-based patient-centered healthcare. This systematic review applies the COnsensus-based Standards for selection of health Measurement INstruments methodology to provide a critically appraised overview of patient-reported outcome measures targeted at pediatric orthopedic patients with lower limb impairment. Method: A systematic search of electronic databases was performed to identify original studies reporting the development and/or validation of patient-reported outcome measures evaluating children with impairment of the lower extremity. Data extraction, quality assessment, and risk of bias evaluation were performed following the COnsensus-based Standards for selection of health Measurement INstruments guidelines and Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. Results: A total of 6919 articles were screened. Thirty-three studies were included, reporting evidence on the measurement properties of 13 different patient-reported outcome measures and 20 translations. Four studies reported on content validity and patient-reported outcome measure development. The methodological quality of studies on structural validity, content validity, or patient-reported outcome measure development was mostly rated as “doubtful” or “very good.” The quality of evidence on measurement properties varied noticeably, with most studies needing to perform improve their methodological quality to justify their results. Conclusion: This review provides an extensive overview of all available patient-reported outcome measures for patients with lower extremity impairment within pediatric orthopedics. We cautiously advise the use of four patient-reported outcome measures. However, the scarce availability of research on content validity and patient-reported outcome measure development highlights an area for future research endeavors to improve our knowledge on the currently available patient-reported outcome measures. Level of evidence: Diagnostic level 1
The global impact of the COVID-19 pandemic on pediatric spinal care: A multi-centric study
Authors: Otremski Hila , Dermott Jennifer , Page Kira , Ipp Lisa S , Blanco John S , Studer Daniel , Sigal Amit , Kim Dorothy , Hasler Carol C , Lebel David E , Widmann Roger F , Ovadia Dror 
Published: November 2023

Background:The COVID-19 pandemic has affected healthcare worldwide since December 2019. We aimed to identify the effect of the COVID-19 pandemic on outpatient clinic and surgical volumes and peri-operative complications for pediatric spinal deformities patients.Methods:In this multi-center retrospective study, outpatient visits (in-person and virtual care) and pediatric spine surgeries volumes in four high-volume pediatric spine centers were compared between March and December 2019 and the same period in 2020. Peri-operative complications were collected and compared in the same periods. Descriptive statistics were calculated, and comparative analyses were performed.Results:During the 2020 study period, the outpatient visit (in-person and virtual care) volume decreased during local lockdown periods by 71% for new patients (p < 0.001) and 53% for returning patients (p = 0.03). Overall, for 2020, there was a 20% reduction in new patients (p = 0.001) and 21% decrease in returning patients (p < 0.001). During the pandemic, there was also 20% less overall surgical volume of adolescent idiopathic scoliosis (AIS) patients undergoing primary posterior spinal fusion, with a 70% reduction during lockdown times (p < 0.001). Complication rate and profile were similar between periods.Conclusion:There was a significant decrease in outpatient pediatric spine outpatient visits, particularly new patients, which may increase the proportion of pediatric patients with spinal deformities that present late, meeting surgical indication. This, in combination with the reduction in surgical volume of AIS over the first year of the pandemic, could result in an extended waitlist for surgeries during years to come. Complication rate was similar for both periods, suggesting it is safe to continue elective pediatric spine surgery even in a time of a pandemic.Level of evidence:level IV.
The effectiveness of telehealth interventions for people with multiple sclerosis: A systematic review and meta-analysis protocol
Authors: Heidari-Soureshjani Reza , Daneshvar Mojtaba , Mohammadi Tayeb , Negarandeh Reza , Sayadi Leila 
Published: November 2023

Objective Multiple sclerosis (MS) is a chronic neurological condition that significantly impacts the quality of life of affected individuals. Telehealth interventions (TIs) have emerged as a promising avenue for providing healthcare services remotely, potentially improving outcomes and enhancing the quality of life for people with MS. This systematic review aims to assess the impact and efficacy of TIs on outcomes of people with MS by synthesizing and comparing outcomes from related randomized controlled trials. Methods The systematic review protocol will involve searching electronic databases (PubMed, Web of Science, Scopus, EMBASE, CENTRAL), gray literature resources, and key journals from 1997 to June 2023 for keywords related to Telehealth and MS. The collection of research-related articles will be followed by the removal of duplicates before they are included in the study. During the screening stage, the titles and abstracts of the articles will be reviewed, and irrelevant articles will be excluded. The full text of relevant articles will be independently evaluated by two researchers, and data will be extracted from the final articles. The findings will be classified and recorded in an extraction table. The risk of bias will be assessed using the Cochrane Collaboration tool. The data will be analyzed using STATA version 14.2. The PROSPERO ID for this study is CRD42023450081. Discussion This study aims to address the current knowledge gap by investigating the comparative effectiveness of TIs. The findings of this research will provide valuable insights and evidence regarding the effectiveness of these interventions, assess their feasibility and accessibility, examine patient outcomes, identify research gaps, and offer guidance for clinical practice and policy-making.