bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum 25-hydroxyvitamin D threshold and risk of rickets in young children: a systematic review and individual participant data meta-analysis to inform the development of dietary requirements for vitamin D
Authors: Rios-Leyvraz Magali , Thacher Tom D. , Dabas Aashima , Elsedfy Heba Hassan , Baroncelli Giampiero I. , Cashman Kevin D. 
Published: January 2024

Abstract
Purpose
The objective of this systematic review was to determine a minimum serum 25-hydroxyvitamin D (25OHD) threshold based on the risk of having rickets in young children. This work was commissioned by the WHO and FAO within the framework of the update of the vitamin D requirements for children 0–3 years old.

Methods
A systematic search of Embase was conducted to identify studies involving children below 4 years of age with serum 25OHD levels and radiologically confirmed rickets, without any restriction related to the geographical location or language. Study-level and individual participant data (IPD)-level random effects multi-level meta-analyses were conducted. The odds, sensitivity and specificity for rickets at different serum 25OHD thresholds were calculated for all children as well as for children with adequate calcium intakes only.

Results
A total of 120 studies with 5412 participants were included. At the study-level, children with rickets had a mean serum 25OHD of 23 nmol/L (95% CI 19–27). At the IPD level, children with rickets had a median and mean serum 25OHD of 23 and 29 nmol/L, respectively. More than half (55%) of the children with rickets had serum 25OHD below 25 nmol/L, 62% below 30 nmol/L, and 79% below 40 nmol/L. Analysis of odds, sensitivities and specificities for nutritional rickets at different serum 25OHD thresholds suggested a minimal risk threshold of around 28 nmol/L for children with adequate calcium intakes and 40 nmol/L for children with low calcium intakes.

Conclusion
This systematic review and IPD meta-analysis suggests that from a public health perspective and to inform the development of dietary requirements for vitamin D, a minimum serum 25OHD threshold of around 28 nmol/L and above would represent a low risk of nutritional rickets for the majority of children with an adequate calcium intake.
Perioperatives Management bei der Versorgung mit aktiven Rhythmusimplantaten
Authors: Krieger Konstantin , Park Innu , Althoff Till , Busch Sonia , Chun K. R. Julian , Estner Heidi , Iden Leon , Maurer Tilman , Rillig Andreas , Sommer Philipp , Steven Daniel , Tilz Roland , Duncker David 
Published: January 2024

ZusammenfassungDie Implantation aktiver Herzrhythmusimplantate („cardiovascular implantable electronic device“, CIED) stellt einen relevanten Teil der modernen Kardiologie dar, und eine sorgfältige perioperative Planung dieser Eingriffe ist notwendig. Präoperativ müssen alle Informationen vorliegen, die für die Indikation, den Eingriff und die Aufklärung relevant sind. Dies stellt die Basis für eine adäquate Geräteauswahl dar. Von entscheidender Bedeutung ist die Vorbeugung von Infektionen, u. a. durch die präoperative Gabe von Antibiotika und den perioperativen Umgang mit der Antikoagulation. Nach erfolgter Operation sind eine postoperative Überwachung, Systemkontrolle und apparative Diagnostik vor der Entlassung erforderlich. Die zunehmende Ambulantisierung erfordert eine Anpassung dieser Prozesse. Die vorliegende Übersichtsarbeit fasst das perioperative Management anhand praktischer Überlegungen zusammen.
Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?
Authors: Kuhn Christian , Mohebbi Nilufar , Ritter Alexander 
Published: January 2024

AbstractMetabolic acidosis is a frequent complication in non-transplant chronic kidney disease (CKD) and after kidney transplantation. It occurs when net endogenous acid production exceeds net acid excretion. While nephron loss with reduced ammoniagenesis is the main cause of acid retention in non-transplant CKD patients, additional pathophysiological mechanisms are likely inflicted in kidney transplant recipients. Functional tubular damage by calcineurin inhibitors seems to play a key role causing renal tubular acidosis. Notably, experimental and clinical studies over the past decades have provided evidence that metabolic acidosis may not only be a consequence of CKD but also a driver of disease. In metabolic acidosis, activation of hormonal systems and the complement system resulting in fibrosis have been described. Further studies of changes in renal metabolism will likely contribute to a deeper understanding of the pathophysiology of metabolic acidosis in CKD. While alkali supplementation in case of reduced serum bicarbonate < 22 mmol/l has been endorsed by CKD guidelines for many years to slow renal functional decline, among other considerations, beneficial effects and thresholds for treatment have lately been under intense debate. This review article discusses this topic in light of the most recent results of trials assessing the efficacy of dietary and pharmacological interventions in CKD and kidney transplant patients.
Bioinformatics analysis of GPS1 expression and biological function in breast cancer
Authors: Wei Hong , Niu Zhaocan , Ji Ruixue , Jiang Wenwen , Tang Jiawei , Meng Zhexuan , Cao Xiaoyang , Zhang Xinyi , Liu Xue 
Published: January 2024

AbstractG protein pathway suppressor 1 (GPS1) is involved in the development of many diseases including tumors, but its specific regulatory mechanism in breast cancer is not clear. The goal of the present study was to explore the biological effects and underlying mechanism of GPS1 in breast cancer. Public databases were used to analyze GPS1 expression and the relationship with clinicopathological characteristics and prognosis of breast cancer patients, combined with in vitro experiments to analyze the mechanism of action and immune relevance of GPS1 in breast cancer. Data analysis showed that the expression of GPS1 in breast cancer tissues was significantly higher than that in paracancerous tissues (p < 0.001), and the receiver operating curve (ROC) revealed a higher diagnostic efficiency (AUC = 0.832). Survival analyses indicated that patients with high GPS1 expression made the prognosis worse in Luminal B, low to intermediate-grade breast cancers. Enrichment analysis showed that GPS1 was involved in the formation of ribonucleoprotein complexes, which dynamically altered the fate of RNA; it could also enhance the responsiveness of the Wnt pathway by interacting with WBP2. In addition, GPS1 expression was closely related to the immune microenvironment. GPS1 knockdown inhibits the proliferation, invasion and migration of MCF7 and MDA-MB-231 cells in vitro. This study suggests that the upregulation of GPS1 is associated with the malignant biological behavior and prognosis of breast cancer and may promote cancer progression. The correlation between GPS1 and the immune microenvironment suggests that it may be a potential target for immunotherapy.
Hydrochemical stratigraphic analysis of the filling of the Meirama mine shaft I: monitoring and filling
Authors: Juncosa Ricardo , Delgado Jorge , Cereijo José Luis 
Published: January 2024

AbstractThe application of an old open-pit lignite mine as an auxiliary reservoir for the supply of the city of La Coruña has involved a detailed analysis of the chemical quality of the vertical profile. The study has shown that a stratified lake is formed where the shape of the filling (first with groundwater and later surface waters from the nearby rivers were added) has influenced the formation of the lake profile. The Meirama mine is an open-pit brown lignite mine located in NW Spain. Exploitation ended in March 2008, leaving a pit of approximately 146 hm3 with a maximum depth of 205 m. The rehabilitation of the pit consisted of the creation of a lake that will serve as an auxiliary water reservoir for the city of La Coruña. The filling process lasted approximately 8 years (March 2008–May 2016) with subterranean and surface contributions from the environment. The formation of an invariant chemocline and a seasonal thermocline was observed. Therefore, in this work, (the first of a series of two articles), an analysis of the evolution of various physicochemical parameters, elements, and compounds at certain heights (the surface, the first 2 m (2 mbs), at 59 masl, and at the bottom (2 masl)). In this first article, the physicochemical parameters of pH, dissolved oxygen, temperature, and some metallic elements (iron and manganese) are analysed. From the analyzed parameters it can be seen the creation of a surface thermocline and a chemocline at a depth of 59 masl with the beginning of the formation of anoxic conditions of the bottom of the pit through the consumption of oxygen.
Contractor selection by using multi-criteria decision-making for Egyptian road maintenance
Authors: Fawzy Mohamed Mahmoud , Elsharkawy Ahmed Shawky , Khalifa Yasser Aly , hassan Abbas Atef 
Published: January 2024

AbstractEgypt has witnessed a revolution in all fields and the establishment of giant projects, which require the selection of the appropriate contractor for their implementation. The major factor for evaluating contractors is the tender price of the project. The lowest price is not always a guarantee of the quality or time of a building project. Recently, there has been a shift away from the “lowest-price-wins” concept and a subjective judgment towards multi-criteria decision-making of selecting the project's contractors aiming to help owners in making decisions. The manuscript presents a multi-criteria decision-making strategy to optimize the selection of contractors for construction projects. The calculation of this strategy is divided into two phases. The first phase is designed to identify contractor prequalification criteria and utilize the AHP approach based on current Egyptian practice to calculate their weight. The second phase provides two techniques: (1) technique for order preference by similarity to ideal solution (TOPSIS) and (2) vlsekriterijumska optimization I kompromisno resenje (VIKOR) to optimize the selection of the available contractors for construction projects. Contractor 2 has the highest prices and lower values in technical capability, economic status, and management capability, it emerges as the top-ranked contractor in both methods due to its exceptional expertise and safety standards. These elevated levels of expertise and safety, coupled with the higher weights assigned by decision-makers to these criteria, contribute significantly to Contractor 2's superior ranking. A real-life case study improvement and refurbishment project is examined to demonstrate the value and highlight capabilities.
A Deep Ensemble Approach for Long-Term Traffic Flow Prediction
Authors: Cini Nevin , Aydin Zafer 
Published: January 2024

AbstractIn the last 50 years, with the growth of cities and increase in the number of vehicles and mobility, traffic has become troublesome. As a result, traffic flow prediction started to attract attention as an important research area. However, despite the extensive literature, traffic flow prediction still remains as an open research problem, specifically for long-term traffic flow prediction. Compared to the models developed for short-term traffic flow prediction, the number of models developed for long-term traffic flow prediction is very few. Based on this shortcoming, in this study, we focus on long-term traffic flow prediction and propose a novel deep ensemble model (DEM). In order to build this ensemble model, first, we developed a convolutional neural network (CNN), a long short-term memory (LSTM) network and a gated recurrent unit (GRU) network as deep learning models, which formed the base learners. In the next step, we combine the output of these models according to their individual forecasting success. We use another deep learning model to determine the success of the individual models. Our proposed model is a flexible ensemble prediction model that can be updated based on traffic data. To evaluate the performance of the proposed model, we use a publicly available dataset. Experimental results show that the developed DEM model has a mean square error of 0.06 and a mean absolute error of 0.15 for single-step prediction; it shows that achieves a mean square error of 0.25 and a mean absolute error of 0.32 for multi-step prediction. We compared our proposed model with many models in different categories; individual deep learning models (i.e., LSTM, CNN, GRU), selected traditional machine learning models (i.e., linear regression, decision tree regression, k-nearest-neighbors regression) and other ensemble models such as random-forest regression. These results also support the claim that ensemble learning models perform better than individual models.
Numerical and experimental assessment of liquid metal embrittlement in externally loaded spot welds
Authors: Prabitz Konstantin Manuel , Antretter Thomas , Rethmeier Michael , El-Sari Bassel , Schubert Holger , Hilpert Benjamin , Gruber Martin , Sierlinger Robert , Ecker Werner 
Published: January 2024

AbstractZinc-based surface coatings are widely applied with high-strength steels in automotive industry. Some of these base materials show an increased brittle cracking risk during loading. It is necessary to examine electrogalvanized and uncoated samples of a high strength steel susceptible to liquid metal embrittlement during spot welding with applied external load. Therefore, a newly developed tensile test method with a simultaneously applied spot weld is conducted. A fully coupled 3D electrical, thermal, metallurgical and mechanical finite element model depicting the resistant spot welding process combined with the tensile test conducted is mandatory to correct geometric influences of the sample geometry and provides insights into the sample’s time dependent local loading. With increasing external loads, the morphology of the brittle cracks formed is affected more than the crack depth. The validated finite element model applies newly developed damage indicators to predict and explain the liquid metal embrittlement cracking onset and development as well as even ductile failure.
MR imaging characterization of pheochromocytoma: a comparison between typical and atypical tumor lesions
Authors: Maurea Simone , Attanasio Ludovica , Galatola Roberta , Romeo Valeria , Stanzione Arnaldo , Camera Luigi , Klain Michele , Simeoli Chiara , Modica Roberta , Mascolo Massimo , Aprea Giovanni , Musella Mario , Brunetti Arturo 
Published: January 2024

Abstract
Purpose
The aim of this retrospective study was to compare the MRI features between typical and atypical pheochromocytomas (Pheos) to specifically illustrate MRI features of atypical tumors for helping tumor diagnosis.

Methods
A total of 22 patients (14 women and 8 men, median age: 53 years, age range: 25–82 years) with Pheos evaluated using a 3 T MRI scanner were retrospectively collected; in particular, all patients had one tumor lesion, except in two cases who had two and three lesions, respectively, for a total of 25 tumor lesions.

Results
Of the total 25 tumor lesions included in our series, 12 lesions were classified as typical for their classical appearance on MRI (T1 hypointensity, T2 hyperintensity, no signal drop on T1 out-of-phase, restricted diffusion and persistent contrast enhancement). Conversely, the other 13 tumors were classified as having atypical lesions because they did not show the MRI features observed in typical Pheos; in particular, 3 lesions showed signal intensity suggestive of tumor hemorrhagic changes, 2 lesions were totally cystic with an internal fluid–fluid level and a thin capsula, 3 lesions showed predominantly cystic signal intensity with residual solid tissue in the peripheral capsula, and the remaining 5 lesions appeared as rounded partially cystic lesions with associated areas of solid tissue.

Conclusion
The imaging characterization of typical Pheos may be performed using MRI with specific imaging features; however, atypical Pheos represents a diagnostic challenge using MRI; in these tumors, cystic, necrotic, hemorrhagic, or fat changes may occur; thus, diagnostic pitfalls should be taken into consideration for MRI interpretation of such tumor type in clinical practice.
Comparison of the cost-effectiveness of sequential treatment with abaloparatide in US men and women at very high risk of fractures
Authors: Hiligsmann Mickael , Silverman Stuart L. , Singer Andrea J. , Pearman Leny , Wang Yamei , Caminis John , Reginster Jean-Yves 
Published: January 2024

Abstract
Background
Osteoporotic-related fractures represent an increasing burden to patients, health care systems and society.

Aims
This study estimated cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) compared to relevant alternative strategies in US men and women aged 50 to 80 years at very high fracture risk (bone mineral density T-score ≤  − 2.5 and a recent fracture).

Methods
A lifetime Markov-based microsimulation model was used to estimate healthcare costs and quality-adjusted life years (QALYs). Comparators were sequential treatment with unbranded teriparatide (TPTD)/ALN, generic ALN monotherapy, and no treatment. Analyses were conducted based on initial fracture site (hip, vertebral, or any fracture) and treatment efficacy data (derived from clinical trials or a recent network meta-analysis).

Results
From all analyses completed, sequential ABL/ALN demonstrated more QALYs for lower healthcare costs versus unbranded TPTD/ALN. No treatment was dominated (higher costs for less QALYs) versus ALN monotherapy. Sequential ABL/ALN resulted in favorable cost-effectiveness (at US threshold of $150,000/QALY) versus generic ALN monotherapy in men aged ≥ 50 years with any fracture type, women aged ≥ 65 years with any fracture type, and women aged ≥ 55 years having a hip or vertebral fracture.

Discussion
Similar cost-effectiveness of sequential ABL/ALN versus unbranded TPTD/ALN, ALN monotherapy, and no treatment was observed in both US men and women at very high fracture risk, with a moderate improvement in cost-effectiveness in men versus women and in patients with a hip or vertebral fracture.

Conclusions
Sequential therapy with ABL/ALN was cost-effective in US men and women at very high risk of fractures.
A Framework for Protecting and Promoting Employee Mental Health through Supervisor Supportive Behaviors
Authors: Hammer Leslie B. , Dimoff Jennifer , Mohr Cynthia D. , Allen Shalene J. 
Published: January 2024

AbstractThe attention to workplace mental health is timely given extreme levels of burnout, anxiety, depression and trauma experienced by workers due to serious extraorganizational stressors – the COVID-19 pandemic, threats to climate change, and extreme social and political unrest. Workplace-based risk factors, such as high stress and low support, are contributing factors to poor mental health and suicidality (Choi, 2018; Milner et al., 2013, 2018), just as low levels of social connectedness and belonging are established risk factors for poor mental health (Joiner et al., 2009), suggesting that social support at work (e.g., from supervisors) may be a key approach to protecting and promoting employee mental health. Social connections provide numerous benefits for health outcomes and are as, or more, important to mortality as other well-known health behaviors such as smoking and alcohol consumption (Holt-Lundstad et al., 2015), and can serve as a resource or buffer against the deleterious effects of stress or strain on psychological health (Cohen & Wills, 1985). This manuscript provides an evidence-based framework for understanding how supervisor supportive behaviors can serve to protect employees against psychosocial workplace risk factors and promote social connection and belongingness protective factors related to employee mental health. We identify six theoretically-based Mental Health Supportive Supervisor Behaviors (MHSSB; i.e., emotional support, practical support, role modeling, reducing stigma, warning sign recognition, warning sign response) that can be enacted and used by supervisors and managers to protect and promote the mental health of employees. A brief overview of mental health, mental disorders, and workplace mental health is provided. This is followed by the theoretical grounding and introduction of MHSSB. Suggestions for future research and practice follow, all with the focus of developing a better understanding of the role of supervisors in protecting and promoting employee mental health in the workplace.
Wish You Were Here? The Economic Impact of the Tourism Shutdown from Australia’s 2019-20 ‘Black Summer’ Bushfires
Authors: Reiner Vivienne , Pathirana Navoda Liyana , Sun Ya-Yen , Lenzen Manfred , Malik Arunima 
Published: January 2024

AbstractTourism, including education-related travel, is one of Australia’s top exports and generates substantial economic stimulus from Australians travelling in their own country, attracting visitors to diverse areas including World Heritage rainforests, picturesque beachside villages, winery townships and endemic wildlife. The globally unprecedented 2019-20 bushfires burned worst in some of these pristine tourist areas. The fires resulted in tourism shutting down in many parts of the country over the peak tourist season leading up to Christmas and into the New Year, and tourism dropped in many areas not physically affected by the fires. Our research quantified the cost of the short-term shock from tourism losses across the entire supply chain using input-output (IO) analysis, which is the most common method for disaster analysis; to this end, we also developed a framework for disaggregating the direct fire damages in different tourism sectors from which to quantify the impacts, because after the fires, the economy was affected by COVID-19. We calculated losses of AU$2.8 billion in total output, $1.56 billion in final demand, $810 million in income and 7300 jobs. Our estimates suggest aviation shouldered the most losses in both consumption and wages/salaries, but that accommodation suffered the most employment losses. The comprehensive analysis highlighted impacts throughout the nation, which could be used for budgeting and rebuilding in community-and-industry hotspots that may be far from the burn scar.
Gravitational Influence on a Nonlocal Thermoelastic Solid with a Heat Source via L–S Theory
Authors: Said Samia M. 
Published: January 2024

Abstract
Purpose
The purpose is to obtain precise expressions of physical fields using the appropriate non-dimensional variables and normal mode analysis.

Methods
Based on the Lord–Shulman (L-S) theory and taking into account gravitational influences as well as temperature-dependent features, the fundamental equations for a nonlocal thermoelastic solid are developed.

Results
When a nonlocal thermoelastic media is swapped out for a thermoelastic one, this approach still holds true. Comparisons are done between the outcomes obtained and those expected for various nonlocal parameter values and for an empirical material constant. Additionally, comparisons are done between the outcomes for various gravity field values.

Conclusion
The nonlocal parameter plays a big part in how the physical fields are distributed. The distributions of the physical fields are significantly influenced by the gravity field.