bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents' Efforts in Instilling Religious Attitudes for Early Childhood through a Religious Psychology Approach in Kp. Bojong
Authors: Suhulah Ghina Agniya , Yulianty Nadya 
Published: October 2023

Children at an early age are a very valuable part, therefore it is termed the golden age, this period will not be repeated a second time. This paper discusses how the internalization of religious attitudes that we must give since early childhood (age 0-6 years). Because at this age, we can instill the values of faith (tawhid), the value of worship and also moral values. These values if internalized at an early age, it will be a provision for the growth and development of children later. Because these values can form a religious attitude in accordance with the basic values of Islam. Islamic education is able to give birth to a religious attitude in children from an early age, if internalized on an ongoing basis. Because Islamic education is an educational system that demands to train students to have values and personalities in accordance with religious demands.
Sumber Kebijakan Luar Negeri Amerika Serikat Di Balik Penandatanganan Abraham Accords
Authors: Lantang Arvy Chrisando , Purnama Chandra 
Published: October 2023

<p>Dalam konteks dinamika politik di Timur Tengah, selain melibatkan peranan dari para aktor regional, terdapat aktor eksternal yang memiliki kepentingan di wilayah tersebut, salah satunya adalah Amerika Serikat. Komitmen Amerika Serikat terhadap para sekutu serta keamanan pasukan militer mereka, salah satunya diimplementasikan melalui kebijakan luar negeri yang dikeluarkan untuk memastikan penandatanganan <em>Abraham Accords</em> antara Israel dengan Uni Emirat Arab, Bahrain, Sudan, dan Maroko. Kebijakan yang diimplementasikan cukup beragam, mulai dari bantuan ekonomi hingga pengakuan politik. Terdapat beberapa sumber yang menjadi dasar dari perumusan kebijakan luar negeri ini. Artikel ini bertujuan untuk memahami apakah atribut nasional dan perilaku aktor lainnya menjadi sumber kebijakan luar negeri Amerika Serikat dalam mencapai penandatanganan <em>Abraham Accords.</em></p><p><em> </em></p><p>Artikel ini menggunakan metode penelitian kualitatif dan konsep sumber kebijakan luar negeri yang dikemukakan oleh K.J. Holsti. Sumber yang digunakan adalah atribut nasional serta perilaku aktor lainnya. Setelah melalui proses analisis, artikel ini menunjukkan bahwa atribut nasional dalam bentuk ukuran dan kapabilitas ekonomi yang dimiliki oleh Amerika Serikat, serta perilaku dan kebijakan dari aktor di Timur Tengah, menjadi salah satu sumber internal dan eksternal yang dapat memberikan pengaruh terhadap perumusan kebijakan luar negeri Amerika Serikat dalam penandatangan <em>Abraham Accords</em></p>
Upaya Pengendalian Kualitas Kadar Moishture Terigu Menggunakan Metode Failure Mode Effect Analysis dan Analisis Cost Of Poor Quality Pada PT. XYZ
Authors: Mu'is Abdul Ghoni , Ismiyah Elly , Rizqi Akhmad Wasiur 
Published: October 2023

PT. XYZ merupakan produsen makanan yang memproduksi tepung terigu. Perusahaan ini memiliki pangsa pasar domestik dan internasional. Tepung terigu ada bermacam-macam merk, salah satunya adalah "AA". Tepung terigu mempunyai standar baku yang beragam, diantaranya kadar air atau moishture. Produk merek AA mempunyai kadar air 14,00%. Namun pada tahun 2022, perusahaan hanya berhasil mendapatkan 13,47% kadar air. Kadar air tepung terigu mempengaruhi berat produk, sehingga kualitas hasil yang buruk dapat menurunkan harga jual. Estimasi COPQ dengan menggunakan rumus dari perusahaan menunjukkan kerugian material akibat kualitas kadar air tepung terigu merk AA pada tahun 2022 yaitu sebesar Rp 11.325.600.000. Diagram tulang ikan digunakan untuk menganalisis sebab dan akibat masalah ini. FMEA dilakukan dengan menggunakan temuan diagram tulang ikan. Menurut penelitian, banyaknya kesalahan yang dilakukan Moish Control menyebabkan kegagalan yang sering terjadi, oleh karena itu penjadwalan pemeliharaan preventif sangatlah penting.
AİHM’İN ÇEVRE İÇTİHATLARININ İKLİM DEĞİŞİKLİĞİ DAVALARINA UYGULANABİLİRLİĞİ
Authors: ALÇIK ENGÜRÜLÜ Merve 
Published: October 2023

Çevre hakkını ayrıca ve açıkça düzenlemeyen Avrupa İnsan Hakları Sözleşmesinin (Sözleşme veya AİHS) denetim mekanizması olan Avrupa İnsan Hakları Mahkemesinin (AİHM) önüne çevre ile ilgili uyuşmazlıklar sıklıkla gelmektedir. Mahkemenin bugüne kadar çevresel meselelerle ilgili vermiş olduğu kararlar özellikle yaşam hakkı, özel ve aile hayatına saygı hakkı ile ilişkilendirilmektedir. Ayrıca Mahkemenin yargı yetkisine dair içtihatları bulunmaktaysa da sınır aşan çevresel zararlara dair yargı yetkisine ilişkin henüz verilmiş bir karar bulunmamaktadır. Yanı sıra son zamanlarda Mahkemeye iklim değişikliğinin zararlı etkileri sebebiyle Sözleşmedeki haklarının ihlal edildiğinden bahisle davalar da açılmaktadır. AİHM önüne gelen iklim değişikliği davaları yeni bir olgu olmasına karşılık henüz bu konuda Mahkeme tarafından verilmiş bir karar bulunmamaktadır.
İklim değişikliği davaları, iklim değişikliğinin zamana yayılan kümülatif etkileri sebebiyle, zarar riskinin ve mağduriyetin kanıtlanması; sınır aşan çevresel zararların meydana gelmesiyle devletlerin yargı yetkisinin belirlenmesi açısından zorluklar taşımaktadır. Bu makale mahkemenin daha önceden verdiği çevre içtihatlarının derdest olan iklim değişikliği davalarında uygulanabilirliğini özellikle sınır aşan çevresel zararlar karşısında mahkemenin yargı yetkisini nasıl belirleyeceği, başvurucuların mağdur statüsünü nasıl değerlendireceği ve yaşam hakkı ile özel ve aile hayatının korunması hakkının ihlal edilip edilmediğini inceleme yöntemi açısından ele almaktadır.
Detection of environmental nanoplastics via surface-enhanced Raman spectroscopy using high-density, ring-shaped nanogap arrays
Authors: Luo Sihai , Zhang Junjie , de Mello John C. 
Published: October 2023

Micro- and nano-plastics (MNPs) are global contaminants of growing concern to the ecosystem and human health. In-the-field detection and identification of environmental micro- and nano-plastics (e-MNPs) is critical for monitoring the spread and effects of e-MNPs but is challenging due to the dearth of suitable analytical techniques, especially in the sub-micron size range. Here we show that thin gold films patterned with a dense, hexagonal array of ring-shaped nanogaps (RSNs) can be used as active substrates for the sensitive detection of micro- and nano-plastics by surface-enhanced Raman spectroscopy (SERS), requiring only small sample volumes and no significant sample preparation. By drop-casting 0.2-μL aqueous test samples onto the SERS substrates, 50-nm polystyrene (PS) nanoparticles could be determined via Raman spectroscopy at concentrations down to 1 μg/mL. The substrates were successfully applied to the detection and identification of ∼100-nm polypropylene e-MNPs in filtered drinking water and ∼100-nm polyethylene terephthalate (PET) e-MNPs in filtered wash-water from a freshly cleaned PET-based infant feeding bottle.
Challenging DESs and ILs in the valorization of food waste: a case study
Authors: Mero Angelica , Moody Nicholas R. , Husanu Elena , Mezzetta Andrea , D’Andrea Felicia , Pomelli Christian Silvio , Bernaert Nathalie , Paradisi Francesca , Guazzelli Lorenzo 
Published: October 2023

In this study, the efficacy of two of the best performing green solvents for the fractionation of lignocellulosic biomass, cholinium arginate (ChArg) as biobased ionic liquid (Bio-IL) and ChCl:lactic acid (ChCl:LA, 1:10) as natural deep eutectic solvent (NADES), was investigated and compared in the pretreatment of an agri-food industry waste, apple fibers (90°C for 1 h). For the sake of comparison, 1-butyl-3-methylimidazolium acetate (BMIM OAc) as one of the best IL able to dissolve cellulose was also used. After the pretreatment, two fractions were obtained in each case. The results gathered through FTIR and TG analyses of the two materials and the subsequent DNS assay performed after enzymatic treatment led to identify ChArg as the best medium to delignify and remove waxes, present on the starting apple fibers, thus producing a material substantially enriched in cellulose (CRM). Conversely, ChCl:LA did not provide satisfactorily results using these mild conditions, while BMIM OAc showed intermediate performance probably on account of the reduced crystallinity of cellulose after the dissolution-regeneration process. To corroborate the obtained data, FTIR and TG analyses were also performed on the residues collected after the enzymatic hydrolysis. At the end of the pretreatment, ChArg was also quantitatively recovered without significant alterations.
A scoring system based on fusion genes to predict treatment outcomes of the non-acute promyelocytic leukemia pediatric acute myeloid leukemia
Authors: Weng Wenwen , Chen Yanfei , Wang Yuwen , Ying Peiting , Guo Xiaoping , Ruan Jinfei , Song Hua , Xu Weiqun , Zhang Jingying , Xu Xiaojun , Tang Yongmin 
Published: October 2023

BackgroundFusion genes are considered to be one of the major drivers behind cancer initiation and progression. Meanwhile, non-acute promyelocytic leukemia (APL) pediatric patients with acute myeloid leukemia (AML) in children had limited treatment efficacy. Hence, we developed and validated a simple clinical scoring system for predicting outcomes in non-APL pediatric patients with AML.MethodA total of 184 non-APL pediatric patients with AML who were admitted to our hospital and an independent dataset (318 patients) from the TARGET database were included. Least absolute shrinkage and selection operation (LASSO) and Cox regression analysis were used to identify prognostic factors. Then, a nomogram score was developed to predict the 1, 3, and 5 years overall survival (OS) based on their clinical characteristics and fusion genes. The accuracy of the nomogram score was determined by calibration curves and receiver operating characteristic (ROC) curves. Additionally, an internal verification cohort was used to assess its applicability.ResultsBased on Cox and LASSO regression analyses, a nomogram score was constructed using clinical characteristics and OS-related fusion genes (CBFβ::MYH11, RUNX1::RUNX1T1, KMT2A::ELL, and KMT2A::MLLT10), yielded good calibration and concordance for predicting OS of non-APL pediatric patients with AML. Furthermore, patients with higher scores exhibited worse outcomes. The nomogram score also demonstrated good discrimination and calibration in the whole cohort and internal validation. Furthermore, artificial neural networks demonstrated that this nomogram score exhibits good predictive performance.ConclusionOur model based on the fusion gene is a prognostic biomarker for non-APL pediatric patients with AML. The nomogram score can provide personalized prognosis prediction, thereby benefiting clinical decision-making.
Analysis of damage-associated molecular patterns in amyotrophic lateral sclerosis based on ScRNA-seq and bulk RNA-seq data
Authors: Shi Yue , Zhu Ruixia 
Published: October 2023

BackgroundAmyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive loss of motor neurons. Despite extensive research, the exact etiology of ALS remains elusive. Emerging evidence highlights the critical role of the immune system in ALS pathogenesis and progression. Damage-Associated Molecular Patterns (DAMPs) are endogenous molecules released by stressed or damaged cells, acting as danger signals and activating immune responses. However, their specific involvement in ALS remains unclear.MethodsWe obtained single-cell RNA sequencing (scRNA-seq) data of ALS from the primary motor cortex in the Gene Expression Omnibus (GEO) database. To better understand genes associated with DAMPs, we performed analyses on cell–cell communication and trajectory. The abundance of immune-infiltrating cells was assessed using the single-sample Gene Set Enrichment Analysis (ssGSEA) method. We performed univariate Cox analysis to construct the risk model and utilized the least absolute shrinkage and selection operator (LASSO) analysis. Finally, we identified potential small molecule drugs targeting ALS by screening the Connectivity Map database (CMap) and confirmed their potential through molecular docking analysis.ResultsOur study annotated 10 cell types, with the expression of genes related to DAMPs predominantly observed in microglia. Analysis of intercellular communication revealed 12 ligand-receptor pairs in the pathways associated with DAMPs, where microglial cells acted as ligands. Among these pairs, the SPP1-CD44 pair demonstrated the greatest contribution. Furthermore, trajectory analysis demonstrated distinct differentiation fates of different microglial states. Additionally, we constructed a risk model incorporating four genes (TRPM2, ROCK1, HSP90AA1, and HSPA4). The validity of the risk model was supported by multivariate analysis. Moreover, external validation from dataset GSE112681 confirmed the predictive power of the model, which yielded consistent results with datasets GSE112676 and GSE112680. Lastly, the molecular docking analysis suggested that five compounds, namely mead-acid, nifedipine, nifekalant, androstenol, and hydrastine, hold promise as potential candidates for the treatment of ALS.ConclusionTaken together, our study demonstrated that DAMP entities were predominantly observed in microglial cells within the context of ALS. The utilization of a prognostic risk model can accurately predict ALS patient survival. Additionally, genes related to DAMPs may present viable drug targets for ALS therapy.
Abnormal phase entrainment of low- and high-gamma-band auditory steady-state responses in schizophrenia
Authors: Nakanishi Shoichiro , Tamura Shunsuke , Hirano Shogo , Takahashi Junichi , Kitajima Kazutoshi , Takai Yoshifumi , Mitsudo Takako , Togao Osamu , Nakao Tomohiro , Onitsuka Toshiaki , Hirano Yoji 
Published: October 2023

IntroductionGamma-band oscillatory deficits have attracted considerable attention as promising biomarkers of schizophrenia (SZ). Notably, a reduced auditory steady-state response (ASSR) in the low gamma band (40 Hz) is widely recognized as a robust finding among SZ patients. However, a comprehensive investigation into the potential utility of the high-gamma-band ASSR in detecting altered neural oscillations in SZ has not yet been conducted.MethodsThe present study aimed to assess the ASSR using magnetoencephalography (MEG) data obtained during steady-state stimuli at frequencies of 20, 30, 40, and 80 Hz from 23 SZ patients and 21 healthy controls (HCs). To evaluate the ASSR, we examined the evoked power and phase-locking factor (PLF) in the time-frequency domain for both the primary and secondary auditory cortices. Furthermore, we calculated the phase-locking angle (PLA) to examine oscillatory phase lead or delay in SZ patients. Taking advantage of the high spatial resolution of MEG, we also focused on the hemispheric laterality of low- and high-gamma-band ASSR deficits in SZ.ResultsWe found abnormal phase delay in the 40 Hz ASSR within the bilateral auditory cortex of SZ patients. Regarding the 80 Hz ASSR, our investigation identified an aberrant phase lead in the left secondary auditory cortex in SZ, accompanied by reduced evoked power in both auditory cortices.DiscussionGiven that abnormal phase lead on 80 Hz ASSR exhibited the highest discriminative power between HC and SZ, we propose that the examination of PLA in the 80 Hz ASSR holds significant promise as a robust candidate for identifying neurophysiological endophenotypes associated with SZ. Furthermore, the left-hemisphere phase lead observed in the deficits of 80 Hz PLA aligns with numerous prior studies, which have consistently proposed that SZ is characterized by left-lateralized brain dysfunctions.
ITC study on the interaction of some bile salts with tragacanth, Arabic, and guar gums with potential cholesterol-lowering ability
Authors: Massa Michele , Compari Carlotta , Fisicaro Emilia 
Published: October 2023

IntroductionThe urge of designing new safe and natural functional foods to control blood lipids and dispensable without the need of physician supervision, has increased especially after the coming into effect of the recent EU Commission regulation 2022/860, that regulates the consumption of “red yeast rice,” made by fermentation of rice with Monascus purpureus, and perceived as a natural functional food, due to a health risk for frail consumers. The results of the present work are a part of the systematic study we are carrying out of the binding ability of some soluble dietary fibers (SDF) from different natural sources toward selected bile salts (BS).MethodsMeasurements were carried out by isothermal titration calorimetry (ITC) with the idea to shed light on the mechanism, if any, by which they show cholesterol-lowering activity.Results and discussionEpidemiological studies are sometimes conflicting and offer only hypothesis about the mechanism of action, the most accredited being the reduction of reabsorption of BS in the gut. Previous measurements done on negatively charged pectin and alginate, showed specific binding interaction with monomer NaDC for pectin and no interaction at all for alginate. Chitosan, positively charged and soluble only at low pH, in 100 mM acetate buffer at pH = 3 shows strong exothermic interactions with NaTC and NaTDC. Here we considered two plant exudates (Arabic gum and tragacanth gum) and guar gum, extracted from guar beans, and their interaction with the same bile salts. ITC measurements do not evidence specific interactions between gums and the studied BS, so that their cholesterol lowering ability, if any, is due to a different mechanism very probably bound to the viscosity increase. Moreover, the addition of NaC, the most abundant BS in the bile, at very low concentration (under the cmc) causes a structural change of the solution. The obtained results seem to corroborate the hypothesis that the cholesterol lowering activity is related to the increase in viscosity of guar solution favored by NaC, the major component of the bile.
Analysis of the COVID-19 vaccine willingness and hesitancy among parents of healthy children aged 6 months–4 years: a cross-sectional survey in Italy
Authors: Postiglione Mario , Miraglia del Giudice Grazia , Della Polla Giorgia , Angelillo Italo Francesco 
Published: October 2023

IntroductionIn Italy, since December 2022, the COVID-19 vaccination has been extended to children aged 6 months–4 years with conditions of fragility and to those healthy at the request of the parent. The purposes of the cross-sectional survey were to determine the willingness and hesitancy of the parents/guardians to have their healthy children vaccinated against COVID-19.MethodsThe survey was performed among 389 parents/guardians with a child aged 6 months–4 years randomly selected from seven kindergartens and eight nursery schools in the geographic area of Naples, Italy.ResultsOnly 10.5% were very concerned about the risk of infection, and the mean values regarding the perceived utility and safety of the COVID-19 vaccine were 3.3 and 3.2, respectively. Only 13.7% of participants were willing to consent to vaccinate the selected child against COVID-19, while 20.1% were uncertain and 66.2% did not intend. Parents/guardians of older children, those who received information about the COVID-19 vaccine from physicians or pediatricians, those who believed that the COVID-19 vaccine was useful, and those with lower hesitancy regarding the COVID-19 vaccine were more willing to vaccinate their child. The mean Parent Attitudes About Childhood Vaccines (PACV-5) score was 5.6, with 33.1% of respondents who were identified as highly hesitant toward COVID-19 vaccination (score ≥ 7). Parents/guardians with a lower perceived safety of the COVID-19 vaccine were more likely to be highly hesitant.DiscussionThe findings reveal the need to improve community-based education campaigns and effective promotion of the COVID-19 vaccination to increase willingness and address parental safety concerns.
Implementation of California COVIDNet – a multi-sector collaboration for statewide SARS-CoV-2 genomic surveillance
Authors: Wadford Debra A. , Baumrind Nikki , Baylis Elizabeth F. , Bell John M. , Bouchard Ellen L. , Crumpler Megan , Foote Eric M. , Gilliam Sabrina , Glaser Carol A. , Hacker Jill K. , Ledin Katya , Messenger Sharon L. , Morales Christina , Smith Emily A. , Sevinsky Joel R. , Corbett-Detig Russell B. , DeRisi Joseph , Jacobson Kathleen ,   the COVIDNet Consortium
Published: October 2023

IntroductionThe SARS-CoV-2 pandemic represented a formidable scientific and technological challenge to public health due to its rapid spread and evolution. To meet these challenges and to characterize the virus over time, the State of California established the California SARS-CoV-2 Whole Genome Sequencing (WGS) Initiative, or “California COVIDNet”. This initiative constituted an unprecedented multi-sector collaborative effort to achieve large-scale genomic surveillance of SARS-CoV-2 across California to monitor the spread of variants within the state, to detect new and emerging variants, and to characterize outbreaks in congregate, workplace, and other settings.MethodsCalifornia COVIDNet consists of 50 laboratory partners that include public health laboratories, private clinical diagnostic laboratories, and academic sequencing facilities as well as expert advisors, scientists, consultants, and contractors. Data management, sample sourcing and processing, and computational infrastructure were major challenges that had to be resolved in the midst of the pandemic chaos in order to conduct SARS-CoV-2 genomic surveillance. Data management, storage, and analytics needs were addressed with both conventional database applications and newer cloud-based data solutions, which also fulfilled computational requirements.ResultsRepresentative and randomly selected samples were sourced from state-sponsored community testing sites. Since March of 2021, California COVIDNet partners have contributed more than 450,000 SARS-CoV-2 genomes sequenced from remnant samples from both molecular and antigen tests. Combined with genomes from CDC-contracted WGS labs, there are currently nearly 800,000 genomes from all 61 local health jurisdictions (LHJs) in California in the COVIDNet sequence database. More than 5% of all reported positive tests in the state have been sequenced, with similar rates of sequencing across 5 major geographic regions in the state.DiscussionImplementation of California COVIDNet revealed challenges and limitations in the public health system. These were overcome by engaging in novel partnerships that established a successful genomic surveillance program which provided valuable data to inform the COVID-19 public health response in California. Significantly, California COVIDNet has provided a foundational data framework and computational infrastructure needed to respond to future public health crises.