bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dramatic response and acquired resistance to savolitinib in advanced intrahepatic cholangiocarcinoma with MET amplification: a case report and literature review
Authors: Zhou Kexun , Liu Yingping , Zhu Hong 
Published: November 2023

BackgroundCholangiocarcinoma (CCA) is an aggressive disease with limited treatment options. Despite substantial efforts to explore better regimens, gemcitabine-based chemotherapy has been the standard first-line treatment for decades. With the growing field of precision medicine, biomarker-guided treatments are gaining popularity. MET alteration is a frequent occurrence in various cancer types, making it a promising target.Case presentationA 53-year-old man visited our hospital with a complaint of upper abdominal pain. Advanced CCA was diagnosed based on the biopsy of the metastatic lymph nodes and immunohistochemistry. Next-generation sequencing revealed MET amplification. As the patient was intolerant to traditional chemotherapy, savolitinib (a c-MET inhibitor) was administered. Partial response was achieved, and the treatment was well tolerated. After 1 year, the patient developed progressive disease, to which the emergence of epidermal growth factor receptor amplification may have contributed.ConclusionOur study verified the therapeutic value of a c-MET inhibitor in advanced CCA-harboring MET amplification and provides an alternative strategy for patients who are intolerant to chemotherapy.
Antiparasitic activity of FLLL-32 against four Babesia species, B. bovis, B. bigemina, B. divergens and B. caballi, and one Theileria species, Theileria equi in vitro, and Babesia microti in mice
Authors: El-Sayed Shimaa Abd El-Salam , El-Alfy El-Sayed , Baghdadi Hanadi B. , Sayed-Ahmed Mohamed Z. , Alqahtani Saad S. , Alam Nawazish , Ahmad Sarfaraz , Ali Md. Sajid , Igarashi Ikuo , Rizk Mohamed Abdo 
Published: November 2023

Introduction: FLLL-32, a synthetic analog of curcumin, is a potent inhibitor of STAT3’s constitutive activation in a variety of cancer cells, and its anticancer properties have been demonstrated both in vitro and in vivo. It is also suggested that it might have other pharmacological activities including activity against different parasites.Aim: This study therefore investigated the in vitro antiparasitic activity of FLLL-32 against four pathogenic Babesia species, B. bovis, B. bigemina, B. divergens, and B. caballi, and one Theileria species, Theileria equi. In vivo anti-Babesia microti activity of FLLL-32 was also evaluated in mice.Methods: The FLLL-32, in the growth inhibition assay with a concentration range (0.005–50 μM), was tested for it’s activity against these pathogens. The reverse transcription PCR (RT-PCR) assay was used to evaluate the possible effects of FLLL-32 treatment on the mRNA transcription of the target B. bovis genes including S-adenosylhomocysteine hydrolase and histone deacetylase.Results: The in vitro growth of B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi was significantly inhibited in a dose-dependent manner (in all cases, p &lt; 0.05). FLLL-32 exhibits the highest inhibitory effects on B. bovis growth in vitro, and it’s IC50 value against this species was 9.57 μM. The RT-PCR results showed that FLLL-32 inhibited the transcription of the B. bovis S-adenosylhomocysteine hydrolase gene. In vivo, the FLLL-32 showed significant inhibition (p &lt; 0.05) of B. microti parasitemia in infected mice with results comparable to that of diminazene aceturate. Parasitemia level in B. microti-infected mice treated with FLLL-32 from day 12 post infection (pi) was reduced to reach zero level at day 16 pi when compared to the infected non-treated mice.Conclusion: The present study demonstrated the antibabesial properties of FLLL-32 and suggested it’s usage in the treatment of babesiosis especially when utilized in combination therapy with other antibabesial drugs.
Apoptosis mechanisms induced by 15d-PMJ2 in HCT116 colon cancer cells: insights into CHOP10/TRB3/Akt signaling
Authors: Albassam Hussam , Ladin Daniel A. , Elhassanny Ahmed , Burns Colin , Van Dross-Anderson Rukiyah 
Published: November 2023

Agents that stimulate the endoplasmic reticulum (ER) stress pathway are being exploited pharmacologically to induce cancer cell death. Cytotoxic ER stress is typically regulated by the transcription factor, C/EBP homologous protein 10 (CHOP10). Products of CHOP10 transcription include the pro-apoptotic proteins: ER oxidoreductase 1α (ERO1α), death receptor-5 (DR5), and tribbles-related protein 3 (TRB3). Our previous findings showed cell death induced by 15-deoxy- Δ12,14 prostamide J2 (15d-PMJ2) occurred in an ER stress-dependent manner. However, the pathway by which 15d-PMJ2 regulates ER stress-mediated death downstream of CHOP10 has not been identified. Our results demonstrate 5 µM 15d-PMJ2 increased CHOP10 expression and apoptosis in HCT116 colon cancer cells. In cells treated with pharmacological inhibitors of ER stress, 15d-PMJ2-induced apoptosis was reliant upon the ER stress pathway. To investigate the role of CHOP10 and its transcriptional products in apoptosis, genetic deletion of CHOP10 (CHOP10-KO) was performed using the CRISPR/Cas9 system. The apoptotic action of 15d-PMJ2 was blunted in cells lacking CHOP10 expression. The deletion of CHOP10 reduced the expression of DR5, ERO1α, and TRB3 although only the expression of TRB3 was significantly reduced. Therefore, we overexpressed TRB3 in CHOP10-KO cells and observed that the activation of Akt was inhibited and 15d-PMJ2-induced apoptosis was restored. Thus, a mechanism of apoptosis elicited by 15d-PMJ2 includes the stimulation of CHOP10/TRB3/Akt inhibition. Given the important role these signaling molecules play in cancer cell fate, 15d-PMJ2 may be an effective inducer of apoptosis in cancer cells.
The influence of physical education courses integrated with civic education on prosocial behavior among college students: the chain mediating effect of cultural confidence and self-esteem
Authors: Huang Changchang , Li Geng , Zhang Yuantong , Aphichaithawon Nalatporn , Deng Zhile , Zhang Zhihua , Zhang Yihan , Ding Jianjun 
Published: November 2023

ObjectiveThis study sought to uncover the relationship between physical education courses integrated with civic education (PECICE) and prosocial behavior among university students. Additionally, we aimed to decipher the mediating roles of cultural confidence and self-esteem within this relationship.MethodsEmploying a questionnaire-based approach, we assessed the relationship among PECICE, cultural confidence, self-esteem, and prosocial behavior in university students. The instrument comprised four distinct scales: the Perceived Effectiveness Scale for PECICE, the Cultural Confidence Scale, the Self-Esteem Scale, and the Prosocial Behavior Scale. Our sample encompassed 293 Chinese college students, consisting of 137 men and 156 women, with an average age of 21.39 years (SD = 2.1).ResultsPECICE demonstrated significant positive associations with cultural confidence (r = 0.29, p &lt; 0.001), self-esteem (r = 0.35, p &lt; 0.001), and prosocial behavior (r = 0.40, p &lt; 0.001). The influence of PECICE on prosocial behavior among university students was mediated through three channels: solely via cultural confidence (mediating effect value: 0.14), solely via self-esteem (mediating effect value: 0.22), and through the combined influence of both cultural confidence and self-esteem (mediating effect value: 0.2).ConclusionThe intertwined mediating roles of cultural confidence and self-esteem highlight their pivotal significance in enhancing the efficacy of PECICE. These insights offer a valuable reference for both educators and policymakers striving to augment prosocial behavior in university students.
The health perception of urban green spaces and its emotional impact on young adults: an empirical study from three cities in China
Authors: Wang Jinsong , Liu Nan , Zou Jiaying , Guo Yanlong , Chen Hong 
Published: November 2023

IntroductionExposure to green space can bring many benefits to physical and mental health, but in China, the attractiveness of green space to youth groups seems to be not significant. The question of how to encourage young people to go out of the house to better perceive green space, enjoy nature, and promote physical and mental health is on our minds.MethodsThis study combines young people’s green space perception, green space use, and purpose of visit to explore its impact on the emotional health of youth groups, combined with the PANAS psychological data scale, an online questionnaire survey of 426 residents (18–35  years old) in three Chinese cities, and was used to construct a multiple regression model and AMOS structural equations.Results and discussionThe results of the study showed that, firstly, environmental attractiveness, environmental odor, and number of facilities were the key factors influencing adolescents’ landscape perception evaluation, while activity space, environmental odor, and environmental attractiveness had a greater impact on adolescents’ emotional well-being. Second, among adolescents’ visit purposes, socializing and fitness were more likely to help them generate positive emotions while resting and viewing activities were effective in helping them alleviate negative emotions. In addition, in terms of usage, residents who took public transportation as well as those who arrived on foot were the most emotionally healthy. The findings of this paper provide insights for public policymakers, urban planners, and landscape architects to better encourage youth participation in green spaces when they are installed.
Pemertahanan Leksikon Fauna Air Tawar di Kalangan Remaja
Authors: Hidayatullah Fathi Ridwan , Rosidin Odien , Damanhuri Yudi 
Published: November 2023

In Sundanese, there is a lexicon of freshwater fauna. This article will describe how the freshwater fauna lexicon of Sundanese society is maintained among teenagers in Leuwiliang sub-district. Lexicon of aquatic fauna which still survive and which have become extinct or displaced. This is sociolinguistic research with an ecological approach. The research uses descriptive analysis methods with qualitative and quantitative data sources. The results of the research show that the lexicon of freshwater fauna among teenagers has begun to shift. The research data amounts to 84 freshwater fauna lexicons. From the results of interviews and questionnaires, information was obtained that 19 (22.6%) freshwater fauna lexicons were no longer used in daily activities, while 65 (77.4%) freshwater fauna lexicons were still used. It is hoped that the results of the research will become a cultural record in the treasures of the Sundanese language so that it can reduce the extinction of the freshwater fauna lexicon of the Sundanese people.Kesywords: lexicon; maintenance; sociolinguisticsAbstrakDalam bahasa Sunda terdapat leksikon fauna air tawar. Artikel ini akan mendeskripsikan bagaimana pemertahanan leksikon fauna air tawar masyarakat Sunda pada kalangan remaja di kecamatan Leuwiliang. Leksikon fauna air apa yang masih bertahan dan yang sudah punah atau tergeser. Ini adalah penelitian sosiolinguistik dengan ancangan ekologi. Penelitian menggunakan metode analisis deskriptif dengan sumber data kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa leksikon fauna air tawar pada kalangan remaja sudah mulai bergeser. Data penelitian berjumlah 84 leksikon fauna air tawar. Dari hasil wawancara dan penyebaran kuisioner diperoleh informasi bahwa 19 (22,6%) leksikon fauna air tawar sudah tidak lagi digunakan dalam kegiatan sehari-hari sedangkan 65 (77,4%) leksikon fauna air tawar masih digunakan. Hasil penelitian diharapkan menjadi sebuah catatan budaya dalam khazanah kebahasan Sunda sehingga dapat mengurangi kepunahan leksikon fauna air tawar masyarakat Sunda. Kata kunci: leksikon; pemertahanan; sosiolinguistik
Elimination of zero-field splitting frequency drift of nitrogen vacancy center ensembles in diamond induced by temperature noise
Authors: Gao Zi Heng , Wen Huan Fei , Wang Ding , Li Xin , Hao Wen Yuan , Liu Yan Jie , Li Zhong Hao , Guo Hao , Ma Zong Min , Tang Jun , Liu Jun 
Published: November 2023

Abstract
The electron spin state of the NV color center in the diamond is optically polarized and read out by laser. However, laser irradiation introduces additional temperature noise, and the zero-field splitting term in the Hamiltonian becomes unstable. The main objective of this study is to explain and eliminate the influence of temperature noise generated by laser power and to propose a laser pulse shaping for detection. Experimental results show that the additional −2.8 MHz frequency drift introduced by the high-power laser is suppressed, under the condition of achieving the same resonance peak contrast of the high-power laser.
Pengaruh Brand Image dan Product Quality Terhadap Purchase Intention Melalui Customer Satisfaction pada Kopi di Coffeeshop di Kota Pekanbaru
Authors: Saputra Yoga Fahmi , Syaefulloh Syaefulloh 
Published: November 2023

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh <em>brand image </em>dan <em>product quality </em>terhadap <em>purchase intention </em>melalui <em>costumer satisfaction </em>pada kopi di <em>coffeeshop </em>di Kota Pekanbaru. Penelitian ini terdiri dari dua variabel independen yaitu <em>brand image </em>dan <em>product quality </em>dan satu variabel dependen yaitu <em>purchase intention </em>serta <em>customer satisfaction </em>sebagai variabel intervening. Metode analisis yang digunakan adalah analisis jalur. Metode pengumpulan data pada penelitian ini adalah dengan menggunakan kuesioner yang diisi oleh responden yaitu konsumen<em> </em>kopi di <em>coffeeshop </em>di Kota Pekanbaru. Hasil penelitian yang didapatkan berdasarkan Uji Parsial (Uji t) diperoleh: a) terdapat pengaruh signifikan <em>brand image </em>terhadap <em>customer satisfaction</em>, b) terdapat pengaruh signifikan <em>product quality </em>terhadap <em>customer satisfaction</em>, c) terdapat pengaruh signifikan <em>brand image </em>terhadap <em>purchase intention</em>, d) terdapat pengaruh signifikan <em>product quality </em>terhadap<em> purchase intention</em>, e) terdapat pengaruh signifikan <em>customer satisfaction </em>terhadap <em>purchase intention</em>, f) <em>customer satisfaction </em>dapat memediasi pengaruh <em>brand image </em>terhadap <em>purchase intention </em>g) <em>customer satisfaction</em> dapat memediasi pengaruh <em>product quality </em>terhadap <em>purchase intention.</em>
IMPLEMENTATION OF THE KLANGEN COFFEE & ROASTERY MARKETING PUBLIC RELATIONS STRATEGY IN FORMING A POSITIVE IMAGE IN THE EYES OF THE PUBLIC
Authors: Pramasti Adiyatni Pranoto  , Niken Ayu Salsabila Putri  
Published: November 2023

TThe development of coffee shop business trends in Indonesia has increased over the last few years. Even though Indonesia was hit by the COVID-19 pandemic, it did not discourage businessmen in the industry. In fact, several businessmen started their businesses during the pandemic, including Klangen Coffee & Roastery. As a businessman who operated during the pandemic, Klangen Coffee & Roastery employed a Marketing Public Relations strategy to survive in the competitive coffee shop business and create a positive image in the public eye. This study uses Harold Lasswell's Propaganda theory and a focus method that includes five elements of communication: source, message, channel or media, receiver, and effect. The research aims to understand Klangen Coffee & Roastery's Marketing Public Relations strategy in shaping a positive image in the public eye. The interpretive qualitative research methodology involves conducting in-depth interviews and observations. The study's results suggest that Klangen Coffee & Roastery's Marketing Public Relations strategy has been successful but not yet fully maximized. Researchers also see that the use of content can have a fairly good impact or effect when delivered through Instagram and TikTok.
Мотиваційні чинники забезпечення якості освіти в закладах вищої освіти в умовах дистанційного навчання
Authors: Джеджера Клавдія 
Published: November 2023

У статті наголошується на необхідності забезпечення якості освіти під час дистанційного навчання. Зазначається, що виконання цього завдання стає можливим за умови засвоєння науково-педагогічними працівниками ІКТ-технологій та методик взаємодії зі здобувачами вищої освіти на відстані, застосування додаткових інтелектуальних і часових витрат з боку педагогів, що значною мірою зумовлене сформованістю в них мотивів удосконалення та інтенсифікації своєї діяльності. Відповідно до цього схарактеризовано актуальні зовнішні та внутрішні демотиваційні чинники професійного самовдосконалення науково-педагогічних працівників у зазначеному напрямі.
Автор статті акцентує увагу на тому, що підвищенню мотивації щодо забезпечення якості освіти сприяє популяризація технологій дистанційного навчання; формування культури якості дистанційної освіти в закладах вищої освіти; спеціальна підготовка, що забезпечує підвищення ІКТ-компетентності педагогів; широке інформування викладачів про новації в системі дистанційної освіти; збагачення академічного середовища закладів вищої освіти цифровими інструментами, засобами візуалізації освітнього процесу, інтенсифікації електронного документообігу та ін.; забезпечення психологічної підтримки викладачів, створення комфортного клімату на кафедрах і факультетах (інститутах) закладів вищої освіти; використання системи адекватних матеріальних та нематеріальних стимулів щодо забезпечення педагогами якісної освіти.
Методологічні аспекти Концепції духовного національного відродження
Authors: Гриців Тетяна 
Published: November 2023

У статті окреслено актуальність та доцільність наукового пошуку, обумовленого Концепцією реалізації державної політики у сфері реформування загальної середньої освіти «Нова українська школа» на період до 2029 року, що спрямована на створення школи, яка мотивуватиме навчатися та даватиме знання, необхідні у повсякденному житті.
Обґрунтовано шляхи розвитку освітнього простору на основі народознавчого потенціалу України та створення виховної моделі Школи духовного національного відродження на основі Концепції національного відродження. Проаналізовано методологічні аспекти Концепції національного відродження, зокрема завдання, наукові підходи, принципи, методи у контексті соціально-культурної парадигми та особливості реалізації програми «Народознавство в дії».
Означено особливості організації освітнього процесу в закладах освіти за виховною моделлю Школи духовного національного відродження, а також визначено освітні пріоритети цієї Школи – дитиноцентризм, педагогіку співробітництва, наскрізний процес виховання на основі духовно-моральних цінностей українського народу й новий зміст освіти на основі народознавства.
Jahnsite-(NaMnMn), a New Jahnsite-Group Mineral from the Wiperaminga Hill West Quarry, Boolcoomatta Reserve, South Australia, Australia
Authors: Elliott Peter , Kampf Anthony R. 
Published: November 2023

Abstract
Jahnsite-(NaMnMn), NaMn2+(Mn2+Fe3+)2Fe3+2(PO4)4(OH)2·8H2O, is a new mineral from the Wiperaminga Hill West Quarry, Boolcoomatta Reserve, Olary Province, South Australia, Australia. The mineral occurs in seams in a matrix comprising triplite, quartz, fluorapatite, and minor pyrite and formed as a result of hydrothermal alteration. Associated minerals are bermanite, phosphosiderite, strengite, and an unknown Mn-Fe phosphate. The mineral occurs as orange-yellow prismatic crystals, elongated parallel to [100], flattened on {001}, exhibiting the forms {001}, {100}, {011}, and {201} that are twinned on {001}. Crystals are up to 80 μm in length and 25 μm across. The Mohs hardness is about 4, the tenacity is brittle, the fracture is splintery, and there is one good cleavage on {001}. The calculated density is 2.774 g/cm3. Jahnsite-(NaMnMn) is biaxial (−) with α = 1.645(3), β = 1.671(3), and γ = 1.674(3) (white light). The measured 2V is 36(1)°. Dispersion could not be observed, and the optical orientation is Z = b. Pleochroism is X = pale yellow brown, Y and Z = light yellow brown; absorption X &lt; Y ≈ Z. Electron probe microanalysis gave the empirical formula (Na0.61Ca0.38)Σ0.99Mn2+(Mn2+1.11Fe3+0.53Mg0.29Mn3+0.07)Σ2(Fe3+1.68Mn3+0.26Al0.06)Σ2(PO4)3.98(OH)2.03·8.05H2O based on 26 O atoms per formula unit. Jahnsite-(NaMnMn) is monoclinic, P2/a, a = 15.1359(10), b = 7.2035(3), c = 9.9876(6) Å, β = 110.361(5)°, V = 1020.92(11) Å3, and Z = 2. The crystal structure has been refined to R1 = 5.70% for 2406 observed reflections with I &gt; 2σI. The new mineral is isostructural with other members of the jahnsite group.
Contextual Teaching And Learning (CTL) Sejarah Batik Dan Pengembangan Potensi Wirausaha Melalui Praktik Kemitraan Membatik
Authors: Siregar Jenny Sista , Djatmiko Wisnu , Nursetiawati Sitti , Josua Diah Pertiwi , Ramadhani Salsabila Tri , Shapira Lidia yULIANTI , Sianturi Ristawati 
Published: November 2023

Kegiatan dilakukan dalam bentuk pelatihan soft skill berupa edukasi budaya dan sejarah Batik, serta hard skill keterampilan bagi peserta didik di SMP Negeri 158 Jakarta. Pelatihan keterampilan untukmencapai kompetensi melukis dan melilin kain. Hasil akhir yang ingin dicapai berupa pengenalan produk guna mengembangkan potensi wirausaha berbasis budaya lokal Jakarta.Proses edukasi Pengabdian Kepada Masyarakat mengacu pada Contextual Teacing and Learning (CTL), yakni; a. Siswa terlibat aktif dalam pembelajaran 4 pertemuan tatap muka dan 2 pertemuan daring, b. Siswa diarahkan menemukan dan menghubungkan materi membatik melalui realita dan situasi kehidupan Jakarta dan Batik dari masa ke masa. Metode pelatihan pada kegiatan ini adalah; 1) analisa situasi, 2) metode tutorial, 3) metode demonstrasi, dan 4) evaluasi. Hasil dari Pengabdian kepada Masyarakat sebagai berikut; a. Siswa antusias mengikuti rangkaian kegiatan terutama pada saat praktik, dan b.Siswa kurang tertarikmengikuti kelas daring,kurangnya minat belajar daring didorong oleh siswa masih menganggap nilai akademis di sekolah lebih penting daripada keterampilan tambahan dari luar sekolah.
The activities carried out took the form of soft skills training in the form of batik culture and history education, as well as hard skills for students at SMP Negeri 158 Jakarta. Skills training to achieve competence in painting and waxing fabrics. The final result to be achieved is product introduction to develop entrepreneurial potential based on Jakarta's local culture.The Community Service education process refers to Contextual Teaching and Learning (CTL), namely; A. Students are actively involved in learning in 4 face-to-face meetings and 2 online meetings, b. Students aredirected to find and connect batik material through the realities and life situations of Jakarta and batik fromtime to time.The training method for this activity is; 1) situation analysis, 2) tutorial method, 3) demonstration method, and 4) evaluation. The results of Community Service are as follows; A. Students enthusiastically participate in a series of activities, especially during practicum, and b. Students are less interested in taking online classes, the low interest in online learning is driven by students still considering academic grades at school to be more important than additional skills from outside school.