bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaling‐up PEM Electrolysis Production: Challenges and Perspectives
Authors: Locci Carlo , Mertens Mara , Höyng Stefan , Schmid Günter , Bagus Thomas , Lettenmeier Philipp 
Published: January 2024

AbstractElectrolysis is fundamental to meet the Paris agreement targets, as it serves as an energy storage technology, with hydrogen being a major energy vector to decarbonize the industry sector. In particular, proton exchange membrane (PEM) electrolysis is well suited for coupling with renewables such as wind turbines and PV. The worldwide objectives for hydrogen ramping up are very ambitious and can only be satisfied with rapid and efficient production. This paper describes how the giga‐factory from Siemens Energy installed in Berlin will play a significant role in satisfying the rising demand of PEM stacks for the company. In addition, challenges such as catalytic material shortage and the need for industrial eco‐systems are discussed.
Real‐world study of palbociclib combined with endocrine therapy for patients with metastatic breast cancer: A comparison of subsequent treatment patterns and HER2 expression analysis
Authors: Liang Xu , Zhang Linhui , Gui Xinyu , Di Lijun , Li Huiping , Song Guohong 
Published: January 2024

AbstractBackgroundCyclin‐dependent kinase 4/6 inhibitors combined with endocrine therapy (ET) comprise the standard treatment for patients with hormone receptor‐positive and human epidermal growth factor 2 (HER2)‐negative metastatic breast cancer. The optimal systematic treatment after progression on palbociclib and the role of HER2 expression among these patients remain unclear.MethodsThe authors retrospectively identified 361 patients who received palbociclib combined with ET. Progression‐free survival (PFS) and overall survival (OS) were analyzed based on subsequent treatments and HER2 status (PFSsub and OSsub, respectively). PFS1 and OS1 were calculated from palbociclib administration to disease progression/death and death from any cause, respectively. PFSsub and OSsub were calculated from subsequent treatment initiation.ResultsThe median PFS1 and OS1 were 10.2 and 39.9 months, respectively. The median PFSsub and OSsub of 111 patients (54.7%) who received chemotherapy were 4.9 months and 20.0 months, respectively, whereas those of 89 patients (43.8%) who received endocrine backbone therapy were 5.9 months and 29.3 months, respectively. Among them, 31 patients (15.3%) who received abemaciclib combined with new ET showed better PFSsub and OSsub (12.2 months and not reached, respectively). The median PFS1 was significantly shorter in the HER2‐low subgroup than in the HER2‐zero subgroup among patients who received second‐line or later palbociclib (6.1 vs. 7.8 months; p = .040) but did not differ among patients who received first‐line palbociclib.ConclusionsVarious regimens after palbociclib use were received. An improvement was noted in PFS among patients who received endocrine backbone therapy relative to chemotherapy, which may have been secondary to the receipt of chemotherapy by patients with more aggressive disease. HER2 status was not related to the effect of first‐line palbociclib, but it may play a role in later lines.
Incorporating patient‐reported outcome data into a predictive calculator for allogeneic hematopoietic cell transplantation recipients
Authors: Shaw Bronwen E. , Flynn Kathryn E. , He Naya , Cusatis Rachel , D'Souza Anita , Hamilton Betty K. , Horowitz Mary M. , Mattila Deborah , Phelan Rachel , Lee Stephanie J. , Brazauskas Ruta 
Published: January 2024

AbstractBackgroundThe Center for International Blood and Marrow Transplant Research (CIBMTR) provides a 1‐year overall survival calculator to estimate outcomes for individual patients before they undergo allogeneic hematopoietic cell transplantation (HCT) to inform risk. The calculator considers pre‐HCT clinical and demographic characteristics, but not patient‐reported outcomes (PROs). Because pre‐HCT PRO scores have been associated with post‐HCT outcomes, the authors hypothesized that adding PRO scores to the calculator would enhance its predictive power.MethodsClinical data were obtained from the CIBMTR and the Blood and Marrow Transplant Clinical Trials Network. The PRO measures used were the 36‐Item Short Form Survey (SF‐36) and the Functional Assessment of Cancer Therapy‐Bone Marrow Transplantation. One thousand thirty‐three adult patients were included.ResultsWhen adjusted for clinical characteristics, the SF‐36 physical component score was significantly predictive of 1‐year survival (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.81–0.95; p = .0015), whereas the mental component score was not (HR, 1.02; 95% CI, 0.95–1.10; p = 0.6396). The baseline single general health question on the SF‐36 was also significantly associated with mortality (HR, 1.91 for those reporting fair/poor health vs. good, very good, or excellent health; 95% CI, 1.33–2.76; p = .0005). The addition of PRO scores to the calculator did not result in a significant change in the model’s predictive ability. Self‐reported pre‐HCT scores were strongly predictive of self‐reported health status (odds ratio, 3.35; 95% CI, 1.66–6.75; p = .0007) and quality of life (odds ratio, 3.24; 95% CI, 1.93–5.41; p < .0001) after HCT.ConclusionsThe authors confirmed the significant, independent association of pre‐HCT PRO scores with overall survival, although adding PRO scores to the survival calculator did not improve its performance. They also demonstrated that a single general health question was as accurate as the full measure for predicting survival, an important finding that may reduce respondent burden and promote its inclusion in routine clinical practice. Validation of these findings should be performed.
Hemophagocytic lymphohistiocytosis induced by nivolumab/ipilimumab combination therapy: A case of lung adenocarcinoma that responded to early steroid pulse therapy
Authors: Hagiwara Satoru , Tanizaki Junko , Hayashi Hidetoshi , Komeda Yoriaki , Nishida Naoshi , Yoshida Akihiro , Yamamoto Tomoki , Matsubara Takuya , Kudo Masatoshi 
Published: January 2024

AbstractBackgroundImmune checkpoint inhibitors have been reported to have excellent therapeutic effects on various malignant tumors. However, immune‐related adverse events can occur, targeting various organs.Case presentationA 49‐year‐old male with lung carcinoma was started on carboplatin + pemetrexed + nivolumab (every 3 weeks) + ipilimumab (every 6 weeks), and nivolumab/ipilimumab was administered in the 3rd course. Subsequently, fever and fatigue developed, and grade 3 liver damage was also noted, so he was admitted to Kindai University Hospital. A bone marrow aspirate examination was performed on the third day of illness, and a definitive diagnosis of hemophagocytic lymphohistiocytosis (HLH) was made. It was determined that immediate therapeutic intervention was necessary, and pulse therapy with methylprednisolone was started on the third day of illness. After 3 days of pulse treatment, a rapid recovery of platelet values, a decrease in ferritin levels, and a decrease in lactate dehydrogenase were observed. Subjective symptoms such as fever and fatigue also quickly improved.ConclusionEarly diagnosis and treatment for HLH resulted in a positive response. The number of HLH cases may increase in the future due to the expansion of immune checkpoint inhibitor indications.
Bloom filter empowered smart storage/access in IoMT [edge‐fog‐cloud] hierarchy for health‐care data ingestion
Authors: Kumar Mandeep , Singh Amritpal 
Published: January 2024

AbstractToday's era of smart technologies has shifted the paradigm of how things work in almost every domain. This change has also affected the utmost need of human beings, that is, sustainability in healthcare. With the help of technologies like the Internet of medical things (IoMT) devices and cloud‐based applications, doctors can now monitor and diagnoses their patients remotely. In the data analytics process for health‐care data, more precision and challenges are present. Data must be transferred from a lower layer to final storage (cloud‐based) during data ingestion so that subsequent operations such as mining, accessing, and streaming can be performed on these data. This article addresses some of the important issues to maintain sustainability in healthcare like authentication, smart scheduling of devices, the removal of redundant data on the final layer, and improving access times for stored data. Bloom filter (a probabilistic data structure)‐based solutions are proposed at different layers of IoMT (edge‐fog‐cloud). The comparative analysis of state‐of‐art techniques with the proposed has shown significant improvement over various metrics. The proposed framework has been evaluated experimentally on real health‐care datasets.
Confucianism and employee treatment: Evidence from China
Authors: Xu Xixiong , Wang Maochuan 
Published: January 2024

AbstractThis study examines the effect of Confucianism, an influential cultural belief and ethical philosophy in East Asia, on employee treatment policies within Chinese listed companies from 2010 to 2020. Our key finding is that Confucianism is positively associated with employee‐friendly practices. We further identify three plausible economic channels through which Confucianism shapes employee‐friendly treatment: valuing human‐centric ethics, mitigating managerial myopia, and alleviating agency conflicts. Cross‐sectionally, the documented impact is more prominent for firms operating with weaker union power and those with executives lacking overseas experience. Additionally, employee‐friendly firms exhibit higher employee efficiency, innovation output, and firm value, indicating that investing in employee benefits ultimately translates into better financial performance. Collectively, we shed light on the unique role of cultural norms in fostering employee treatment policies and their consequential effects on organizational value.
Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms
Authors: Kagerer Sonja M. , Awasthi Swapnil , Ripke Stephan , Maceski Aleksandra , Benkert Pascal , Fall Aïda B. , Riederer Peter , Fischer Peter , Walitza Susanne , Grünblatt Edna , Kuhle Jens , Unschuld Paul G. 
Published: January 2024

AbstractINTRODUCTIONEstablishing valid diagnostic strategies is a precondition for successful therapeutic intervention in Alzheimer's disease (AD).METHODSOne hundred forty‐four healthy 75‐year‐old participants from the Vienna‐Transdanube‐Aging longitudinal cohort study were tested for neuroaxonal damage by single molecular array (Simoa) plasma neurofilament light chain (NfL) levels at baseline, 30, 60, and 90 months, and onset of AD dementia. Individual risk for sporadic AD was estimated by continuous shrinkage polygenic risk score (PRS‐CS, genome‐wide association study).RESULTSNineteen participants developed AD after a median of 60 months (interquartile range 30). In participants with AD, baseline NfL plasma levels correlated with PRS‐CS (r = 0.75,p < 0.001; difference to controls: Fisher'sr‐to‐z:z = 3.89,p < 0.001). PRS‐CS combined with baseline plasma NfL predicted onset of AD (p < 0.01).DISCUSSIONOur data suggest that polygenic risk for AD and plasma NfL closely interact years before onset of clinical symptoms. Peripheral NfL may serve as a diagnostic measure supporting early therapeutic intervention and secondary prevention in AD.
Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation
Authors: Hunter Sharon K. , Hoffman M. Camille , D'Alessandro Angelo , Freedman Robert 
Published: January 2024

AbstractCholine and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods during gestation, choline stimulation of α7‐nicotinic receptors facilitates the conversion of γ‐aminobutyric acid (GABA) receptors from excitatory to inhibitory and recruitment of GluR1‐R2 receptors for faster excitatory responses to glutamate. The outcome of the fetal development of inhibition and excitation was assessed in 159 newborns by P50 cerebral auditory‐evoked responses. Paired stimuli, S1 and S2, were presented 500 ms apart. Higher P50 amplitude in response to S1 (P50S1microV) assesses excitation, and lower P50S2microV assesses inhibition in this paired‐stimulus paradigm. The development of inhibition was related solely to maternal choline plasma concentration and folate supplementation at 16 weeks’ gestation. The development of excitation was related only to maternal choline at 28 weeks. Higher maternal choline concentrations later in gestation did not compensate for earlier lower concentrations. At 4 years of age, increased behavior problems on the Child Behavior Checklist 1.5–5 years were related to both newborn inhibition and excitation. The incomplete development of inhibition and excitation associated with lower choline and folate during relatively brief periods of gestation thus has enduring effects on child development.
Significant Effect of 2nd Sphere Interactions on the Reductive Activation of O2 by non‐heme Iron(II) Complexes – Application to the Electroassisted Oxidation of Thioanisole
Authors: Robinson Amanda Lyn , Bannerman Eva , Guillot Régis , Herrero Christian , Sénéchal‐David Katell , Rivière Eric , Banse Frédéric , Rebilly Jean‐Noël 
Published: January 2024

AbstractNew mononuclear non‐heme FeII complexes derived from a well‐known pentadentate amine/pyridine ligand were synthesized. The new ligand bears an additional OH group on one pyridyl aimed at developing second sphere hydrogen bonds. Two binding modes of the ligand were observed that can be selectively obtained through the choice of the counterion: the OH group develops an intramolecular H‐bond with the 6th exogenous ligand in the classical mode, or an intermolecular one with the unbound triflate counterion in the alternative mode. The complexes were studied by cyclic voltammetry in the reductive activation of O2. The addition of an H‐bond improves the O2 activation potential with a gain of 90 mV in the classical case and 220 mV in the alternative one. The difference is ascribed to the development of stabilizing H‐bonds within the FeIII‐peroxo intermediate with the proximal O atom of peroxo (classical mode) or the distal one (alternative mode). Ultimately, the complex in the alternative mode activates O2 at −0.5 V vs SCE (500 mV gain compared to free O2). We took advantage of this significantly reduced energetic cost to carry out and achieve the electroassisted oxidation of thioanisole by O2 at −0.5 V vs SCE.
How are elite tennis matches won at Wimbledon? A comparison of close and one‐sided contests
Authors: Fitzpatrick Anna , Stone Joseph A. , Choppin Simon , Kelley John 
Published: January 2024

AbstractNotational analysis investigations of several sports have suggested that the performance characteristics associated with success differ by match closeness. It is not known whether this is the case in tennis. Therefore, this study aimed to first develop operational definitions for closely contested and one‐sided tennis matches, then establish whether the important performance characteristics in elite grass court tennis differ by match closeness. Data from 365 men and 374 women's Wimbledon single matches played between 2015 and 2017 were analyzed. Irrespective of match closeness, points won of 0–4 shot rally length, first serve points won and baseline points won were associated with winning matches, and forced errors and unforced errors were associated with losing matches, for both sexes. Spearman's rank‐order correlations demonstrated excellent agreement between the importance of the performance characteristics in closely contested and one‐sided men (rs = 0.89, p < 0.001) and women's matches (rs = 0.90, p < 0.001), respectively. Findings suggest that expected match closeness (of an upcoming match) should not necessarily influence decision‐making around practice design and match‐play strategy. Additionally, the operational definitions developed for closely contested and one‐sided matches developed here could be used in future studies to investigate different competitive contexts.
Synthesis strategies of smart 3D nanoarchitectures and their applications in energy storage and conversion
Authors: Loura Nisha , Mor Sumit , Nandal Deepak , Nandal Vikas , Dhull Vikas 
Published: January 2024

AbstractThe creation of effective and clean energy storage technologies has advanced dramatically due to growing worldwide worries over the depletion of fossil fuels and environmental issues. Energy storage and conversion systems have emerged as a crucial component with the development of numerous electronic devices, enabling the devices to function for extended periods of time. Due to their enormous surface area, strong electrical conductivity, and ion transport, 3D self‐supported nanoarchitectures associated with electrochemical energy storage (EES) devices can offer alternatives for enhancing the performance and advancement of existing EES systems. Here, we present the results of our findings regarding the design, production, and use of self‐supported 3D nanostructures in energy storage and conversion systems such as supercapacitors, batteries, solar cells, and fuel cells. A variety of advanced 3D nanomaterials may be readily created on an immense scale using various synthetic techniques, and they have a great deal of potential for use as electrodes in energy storage and conversion devices with much better performance. These fabrication techniques include electrochemical deposition, electrospinning, chemical precipitation, spray pyrolysis, sol‐gel method, hydrothermal method, chemical vapor deposition, and so forth.
Microencapsulation of anthocyanins extracted from black soybean peels by whey protein/fructo‐oligosaccharide contributes to improved stability, bioavailability, and ability to regulate glycolipid metabolism
Authors: Zhang Wenbao , Li Xusheng , Ma Xiaoqiang , Li Haoyu , Liu Jia , Zeng Yingyu , Cai Dongbao , Xu Qingjie , Chen Guobing , Tian Lingmin , Sun Jianxia , Bai Weibin 
Published: January 2024

AbstractBlack soybean peels (BSPs) are rich in anthocyanins (ANCs), a naturally active substance added to manufactured foods. However, the instability of the ANC structure limits its application in the food industry. In the present study, an efficient and simple microencapsulation method to improve the stability of ANC was successfully established. BSP ANCs were encapsulated in a microencapsulated complex with fructo‐oligosaccharide (FOS) and whey protein (WP) associated with a high encapsulation rate (65.41%) and drug‐loading capacity (6.13%). The particle size and polydispersity index of anthocyanin‐loaded microencapsulation (ALM) were 4.648 ± 0.350 µm and 0.405 ± 0.107, respectively. The ANC stability test showed that ALM performed enhanced thermostability, pH stability, storage stability, and light stability. Meanwhile, in vitro release experiments indicated that ALM dramatically delayed the contact time of ANC with the environment and reduced the degradation. Moreover, animal experiments demonstrated that ALM better improved blood glucose homeostasis and lipid homeostasis in high‐fat‐ and high‐fructose‐treated mice and reduced liver lipid accumulation and damage. Additionally, the better in vivo bioactivity could be attributed to the extended bioavailability that was proved by a pharmacokinetics test. These results suggested that the microencapsulation employed WP‐FOS complexes as the wall materials are of great potential to improve the stability and health‐promoting properties of ANC, providing a promising solution as dietary supplementation.
Danish consumers’ knowledge about and willingness to buy dairy products close to the best‐before‐date
Authors: Melgaard Carina V. , Voss Emily , Hansen Majken F. , Lassen Marlene , Hvidtfeldt Michelle , Pandey Sujita , Rasmussen Morten Arendt , Thomsen Marianne 
Published: January 2024

AbstractMore than 700,000 tons of food are wasted annually in Denmark where dairy products are among the 10 most wasted food products. Therefore, this study aims to analyze Danish consumers’ understanding of the best‐before‐date label and relational patterns for different knowledge‐attitude‐behavior factors influencing their willingness to buy (WTB) dairy products close to the best‐before‐date. Respondents (n = 436) from an online survey were segmented into four segments based on (i) their frequency of purchasing and (ii) their WTB dairy products close to the best‐before‐date: low/low (n = 53), medium/low (n149), medium/high (n = 190), and high/high (n = 44). All four segments had a relatively high understanding of the best‐before‐date label (total mean score = 2.43). For the medium/high and high/high segments, drivers for buying dairy products close to the best‐before‐date were avoidance of food waste, reduced price, and organic certification. However, the low/low and medium/low segments refrained from purchasing dairy products close to the best‐before‐date due to health concerns and low‐quality perception and found them unappetizing. Furthermore, there seems to be a tendency for an age‐dependent pattern. Older respondents (low/low and medium/low) had a higher risk perception than the younger respondents (medium/high and high/high). Consumers’ level of risk perception and food disgust sensitivity are the actual drivers or barriers for consumers’ WTB dairy products close to the best‐before‐date and not their level of knowledge. The results obtained from this study contribute valuable insights into consumer values and can be crucial for developing strategies to reduce food waste in an environment where consumers make their purchasing decisions.
Paternal preconceptional supplementation of n‐3 polyunsaturated fatty acids alleviates offspring nonalcoholic fatty liver disease in high‐fat diet‐induced obese mice
Authors: Shi Qiaoyu , Fan Xiuqin , Yang Mengyi , Tang Tiantian , Wang Rui , Li Ping , Qi Kemin 
Published: January 2024

AbstractExposure to nutritional or environmental factors in early life determines susceptibility to nonalcoholic fatty liver disease (NAFLD). The effect of paternal preconceptional n‐3 polyunsaturated fatty acids (n‐3 PUFAs) on offspring NAFLD development remains unknown. Herein, a mouse model that weaning male mice (F0) received diet supplementation of normal n‐3 PUFA content (n‐6:n‐3 PUFA ratio = 4.3:1) or high n‐3 PUFA content (n‐6:n‐3 ratio = 1.5:1) for 12 weeks, and an n‐3 PUFA‐deficient diet as control, was used for the production of next generation. The F1 and F2 offspring were generated by mating F0 and F1 male mice with virgin female mice, respectively, and after weaning, were fed a high‐fat diet to induce NAFLD. The paternal n‐3 PUFA supplementation improved the scores of steatosis, inflammation and ballooning, and the fibrosis in the liver of two generations, with expressional upregulation of genes associated with fat oxidation (Atgl, Ppara, or Cpt1a), and downregulation of inflammatory genes (Ccl2, Tnf‐α, F4/80, CD206, or CD11c) and fibrosis genes (Tgf‐β, Timp1, or Col1a1). The lessened brown adipose tissue whitening, altered gut bacterial compositions, and altered expression of the imprinted genes (H19, Igf2, and Plagl1) might mediate the impact of paternal n‐3 PUFAs on offspring's NAFLD development, which was dose‐dependent. The data indicate that preconceptional higher paternal intake of n‐3 PUFAs might have intergenerational and transgenerational alleviating impact on obesity‐associated NAFLD development in the offspring through multiple pathways.