bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis: A Multicenter Experience
Authors: Berinstein Jeffrey A. , Karl Taylor , Patel Anish , Dolinger Michael , Barrett Terrence A. , Ahmed Waseem , Click Ben , Steiner Calen A. , Dulaney David , Levine Jake , Hassan Syed Adeel , Perry Courtney , Flomenhoft Deborah , Ungaro Ryan C. , Berinstein Elliot M. , Sheehan Jessica , Cohen-Mekelburg Shirley , Regal Randolph E. , Stidham Ryan W. , Bishu Shrinivas , Colombel Jean-Frederic , Higgins Peter D.R. 
Published: January 2024

INTRODUCTION:
A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.

METHODS:
Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.

RESULTS:
Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.

DISCUSSION:
Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC.
Vitamin D metabolism in diabetic nephropathy
Authors: Abilov Z. V. , Salimkhanov R. Kh. , Povaliaeva A. A. , Zhukov A. Yu. , Pigarova E. A. , Dzeranova L. K. , Rozhinskaya L. Ya. 
Published: January 2024

Diabetic nephropathy (DN) is a specific kidney involvement in diabetes mellitus (DM), caused by hemodynamic and metabolic factors. In the kidneys takes place an important step in the metabolism of vitamin D — 1α-hydroxylation, which results in the formation of its biologically active form. Reduced number of functioning nephrons in DN leads to impaired vitamin D metabolism, contributing to the development of a number of complications. In this review, we have focused in detail on both normal vitamin D metabolism and the features of vitamin D metabolism in chronic kidney disease (CKD). DN is the most common cause of CKD and, as a consequence, of kidney transplantation and one of the leading causes of cardiovascular morbidity and mortality in patients with DM. Bone mineral disorders resulting from abnormal vitamin D metabolism are also independent factors of high mortality among patients with DM. The final part of our review briefly highlights current approaches to vitamin D therapy in CKD and, in particular, in DN. It is worth noting that, despite the increasing number of patients with DN, there is currently no unified view on the use of vitamin D as a therapeutic agent in this pathology.
1166A>C polymorphism of the <i>AGTR1</i> gene as a marker metabolic disorders in the North residents
Authors: Bezmenova I. N. , Averyanova I. V. 
Published: January 2024

BACKGROUND:dyslipidemia is currently considered to be one of cardiovascular risk factors. Angiotensin II receptor type I (AGTR1) genetic polymorphisms are known as candidate genes for hypertension, diabetes, as well as for diabetes and obesity complications. Until now, there are not much data on how 1166A>C (rs5186) polymorphism of the AGTR1 gene correlates with Northerners’ carbohydrate and lipid metabolism disorders. In addition, the data are contradictory. Following on from this, we see it is relevant to study the subject.AIM:this research assessed variants of 1166A>C (rs5186) polymorphism of the AGTR1 gene as a predictor of dyslipidemia, carbohydrate metabolism disorders, overweight, and hypertension.MATERIALS AND METHODS: the North residents from Magadan Region, Caucasian by ethnicity, aged from 24 to 56 (average age 43.7± 1.4 yrs) participated in the survey. By real-time polymerase chain reaction we determined the single nucleotide polymorphism of the AGTR1 (rs5186) gene. We also analyzed physical development and cardiovascular variables as well as the concentrations of glucose, insulin, glycosylated hemoglobin, C-reactive protein, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. The insulin resistance index and the atherogenicity coefficient were calculated using standard methods.RESULTS:the examined subjects were one hundred and one volunteers. According to the results of genetic analysis, 55 people were assigned to the group of homozygotes for the wild type (AA) and 46 people were assigned to the group of the AGTR1*C allele variant carriers (heterozygotes and homozygotes AC+CC). Our findings contributed to the evidence on more unfavorable lipid pictures showed by the AGTR1*C allele variant carriers: significantly high values of total cholesterol (5,77±0,11, р=0.045), low-density lipoproteins (3,87±0,09, р=0.009), triglycerides (1,43±0,06, р=0.035), and atherogenicity coefficient (3,61±0,10, р=0.001), along with significantly low values of high-density lipoproteins (1,30±0,03, р=0,008). The above indicators were observed as opposed to significantly high fasting glycemia (5,74±0,14, р=0.006) and glycosylated hemoglobin (5,74±0,09, р=0.001) exhibited by the AA homozygotes subjects whose indices could be defined as the state of prediabetes. No intergroup differences were found in anthropometric or cardiovascular variables.CONCLUSION:thus, we could see impairments in the lipid pictures of the AGTR1*С polymorphic variant carriers along with the optimization of carbohydrate metabolism and no effect on the blood pressure or anthropometric characteristics.
De la protection de l’environnement dans les Constitutions Algeriennes
Authors: Tabti Rabah 
Published: January 2024

Depuis son indépendance en 1962, l’Algérie a subi des transformations politiques et environnementales. Malgré les obstacles de la reconstruction, la préoccupation environnementale s’est graduellement inscrite dans les textes fondamentaux du pays, notamment les chartes et les constitutions. Même si la constitution de 1963 était muette sur l’environnement, révélant un manque d’attention à l’époque ; mais depuis 1976, des évolutions significatives ont surgi, avec l’implémentation de politiques environnementales axées sur la préservation de la nature. Les chartes nationales de 1976 et 1986, ainsi que les constitutions de 1976, 1989, 1996, 2008, 2016 et particulièrement celle de 2020, ont toutes impulsé des mesures pour la protection de l’environnement. Ces textes fondamentaux sont sans équivoque quant à l’urgence de préserver la nature face au dérèglement climatique et à la nécessité d’une action immédiate. Ces évolutions législatives, notables et révolutionnaires, ont élevé le statut de l’environnement dans le cadre législatif et juridique algérien, témoignant d’une harmonie retrouvée entre l’Algérie, ses valeurs culturelles, son histoire et ses engagements internationaux.
Dans ce contexte, une lecture critique a scruté la prise en charge de l’environnement et du climat dans les diverses constitutions et textes juridiques algériens. Les résultats mettent en avant l’importance attribuée à la protection de la nature dans ces documents, tout en soulignant le besoin d’une mise en œuvre plus efficace sur le terrain. Malgré les progrès notables depuis l’indépendance, avec l’émergence de politiques environnementales et l’intégration de la question environnementale dans les textes fondamentaux, l’Algérie doit encore déployer d’importants efforts pour concrétiser ces lois et véritablement préserver la nature sur son territoire.
Bringing the campaign closer to the voters: Facebook in partisan-managed campaigning in France
Authors: Neihouser Marie , Figeac Julien 
Published: January 2024

Abstract
During presidential campaigns, party members often operate Facebook pages or groups concurrently with the official communications of their respective political parties. However, there is limited evidence regarding the true motivations of these partisans, and how their efforts supplement the online strategies of the parties. Our study is based on interviews conducted with party members who ran Facebook pages to support a candidate during the 2022 French presidential campaign. It sheds light on how they managed their Facebook pages, often autonomously, to serve as supplementary tools to their grassroots tactics and ultimately to bring the campaign closer to the voters. This finding highlights the emergence of a hybrid model of online campaign organization, the partisan-managed campaigning model, which challenges both the traditional top-down model, in which the campaign is managed by the central party, and the more recent citizen-initiated campaign model.
Atomic-level mechanisms of short-circuit diffusion in materials
Authors: Chesser Ian , Koju Raj K. , Mishin Yuri 
Published: January 2024

Abstract
This paper reviews the recent progress in understanding the atomic mechanisms of short-circuit diffusion along materials interfaces, such as grain and interphase boundaries, as well as lattice and interfacial dislocations/disconnections. Recent atomistic computer simulations have shown that short-circuit diffusion is dominated by collective atomic rearrangements in the form of strings and rings of mobile atoms. The process is dynamically heterogeneous in space and time and has many features in common with atomic dynamics in supercooled glass-forming liquids. We discuss examples of grain boundary, interphase boundary, and dislocation diffusion in metals and alloys, including the solute effect on the diffusion rates and mechanisms. Interphase boundaries are exemplified by Al–Si interfaces with diverse orientation relationships and atomic structures. The hierarchy of short-circuit diffusion paths in materials is reviewed by comparing the rates of grain boundary, interphase boundary, and dislocation diffusion. Future directions in the field of short-circuit diffusion in defect core regions are discussed.
Magnetic properties of NdFeB-based alloy under high-pressure torsion
Authors: Mazilkin Andrey , Protasova Svetlana , Straumal Boris , Davdyan Gregory 
Published: January 2024

Abstract
When a multicomponent NdFeB-based magnetic alloy is deformed using high-pressure torsion (HPT), a quasi-stationary state is reached after 2.5 anvil revolutions, which corresponds to an equivalent strain of ∼40 at the sample mid-radius. In this state, torque self-oscillations are observed with a period of about 1.5 s and an amplitude of ∼10 % around the average value of 550 N m−1. Such self-oscillations are accompanied by strong acoustic emission. Before HPT, the alloy under study has an almost rectangular hysteresis loop with saturation magnetization J
s = 135 emu g−1 and coercivity H
c = 34.8 kOe. HPT deformation at initial stages transforms this alloy to the class of soft magnets: H
c drops to 1.35 × 10−4 kOe, while J
s practically does not change. An increase in strain leads to a gradual increase in H
c to 9.61 kOe and a decrease in J
s to ∼100 emu g−1 at the number of anvil revolutions n = 7. This is explained by HPT modification of the regular grain-boundary network of neodymium-rich paramagnetic phase layers. These layers provide magnetic isolation between grains of the Nd2Fe14B ferromagnetic phase. Periodic changes in torque and J
s with increasing torsion angle are caused by transitions from the amorphous phase to the crystalline one and vice versa.
Experimental investigation on the mechanical and wear behavior of epoxy/Indian almond/peepal hybrid composites
Authors: Xavier X. Roshan , Suderson K. , Viswanath K. , Velmurugan D. 
Published: January 2024

Abstract
Natural fiber-based hybrid composites are gaining more attention in industrial usage due to their low cost, environmental friendliness, and simplicity of processing. In this research, an effort was made to create hybrid natural composites using Indian almond and peepal fibers for applications in the automotive industry. Composites were prepared with different volume fractions of Indian almond and peepal fibers using the hand layup process. The mechanical and tribological properties of the composites were tested. The epoxy/40 wt% peepal composite showed superior performance compared to all other composites due to the better strength of peepal fiber. Moreover, the same composite displayed the least wear loss and coefficient of friction (COF). The present study confirms that peepal fiber composites match the strength properties of existing industrial composite materials, and that they may be some of the alternative composites for automotive applications.
A round altar with a Carian inscription from Euromos
Authors: Kızıl Abuzer , Adiego Ignasi-Xavier 
Published: January 2024

Abstract
This article presents a new Carian inscription found in the Temple of Zeus Lepsynos in the Carian city of Euromos during excavations carried out in 2022. The inscription is carved on a round altar from the archaic period. The text is brief and incomplete, but its reading does not pose serious problems and an onomastic formula is recognisable.
Shaping the Pamphylian alphabet: the puzzle of the two digammas
Authors: Selvi Eleonora , Santamaria Andrea 
Published: January 2024

Abstract
The origins and development of the Pamphylian alphabet and its relations with the other Greek alphabetic traditions have so far remained obscure. This study aims at elucidating the feature that, more than any other, has resisted a safe interpretation: the coexistence, without parallels in the Greek world, of at least two graphemes, namely <Ͷ> and <Ϝ>, representing the posterior approximant. To unravel the intricacy, we adopt a novel perspective, namely the ‘corpus doctrinae theory’, in order to address potential biases arisen from structuralist approaches. Preliminarily, we argue, on the basis of the distribution of the two graphemes, that such a cohabitation cannot always be explained by phonetic reasons. Therefore, we discuss the selection of <Ͷ> and <Ϝ> in the broader frame of the formation and transmission of the Greek alphabets, showing that Pamphylian did not stem from a single matrix-script, but rather goes back to the NE Peloponnesian corpus doctrinae. Such a filiation explains the origins of <Ͷ>, as both its paleography and phonetic value show that it is an adaptation of the Corinthian- type <B>.
New Lycian and Greek graffiti from Patara: edition and onomastic commentary
Authors: Réveilhac Florian , Dündar Erkan 
Published: January 2024

Abstract
In this article are published four new graffiti found in the Tepecik settlement in the Lycian harbour of Patara. These inscriptions, three of which are written in Lycian, and one in Greek, are dated from the mid-fifth to the first quarter of the third century BC. They correspond to Lycian personal names, most of which are new. Each of these forms is discussed in detail and compared with related names attested in other Anatolian languages.
Effect of welding parameters on cruciform weld joints made of armor steel
Authors: Uzunali Umut Yasar , Cuvalci Hamdullah 
Published: January 2024

Abstract
It is aimed to examine the effect of welding parameters on cruciform welded joints. Armor steels are used in military applications such as tracked and wheeled armored vehicles. These steels are quenched and tempered steels and have high yield stress and hardness. Although the increase in carbon equivalent increases the ballistic level together with the hardness value, weldability decreases. Therefore, the welding parameters of these steels must be determined carefully. Before the welding, chemical analysis, macro examination, hardness test, tensile tests and ultrasonic examination were carried out to verify the material properties. After the verification tests, plates were welded with three different welding parameters to observe the changing of the mechanical properties. After the welding process, welded pieces were subjected to non-destructive tests to inspect the weld imperfections. After the inspection, welded specimens were subjected to hardness test, macro examination and tensile tests. In addition to these tests, weld penetration (WP) measurements were performed with a new assessment method. In this measurement method, unit of area takes into consideration instead of the unit of length. As a result, it is determined that with the increasing welding parameters although WP increase, hardness values in heat affected zone decrease.
Influence of water on microstructure and mechanical properties of a friction stir spot welded 7075-T651 Al alloy
Authors: Ekinci Omer , Imak Anil 
Published: January 2024

Abstract
7075-T651 Al alloy sheets were welded by friction stir spot welding (FSSW) method without and with tap water. Conducting FSSW with water reduced the weld microstructure grain size and the hook defect formation at the weld, resulting in an increase in the hardness and tensile strength of the weld. The joint made with water showed an average tensile load of 4237 N, whereas the joint made without water exhibited 3690 N. Using water enhanced the strength of the joint, but slightly decreased its ductility. The hardness of the joint made with water presented slightly higher, probably due to the formation of smaller grains in its microstructure as a result of the water leading to a decrease in the welding process temperature. In both joints, the highest hardness measurements in the stir zones (SZs) and the lowest ones in the heat-affected zone (HAZ) and thermo-mechanically affected zone (TMAZ) were found as the SZs had a finer-grained microstructure. Furthermore, the application of water noticeably, though not completely, inhibited the occurrence of the hook defect in the joint and also reduced the sizes of HAZ and TMAZ. According to the weld fracture surface analysis, both joints failed in a ductile manner.
Agencia y transgresión en los personajes femeninos migrantes de Claudia Hernández y
Antonio Ortuño
Authors: Galvez Cuen Marissa 
Published: January 2024

El presente trabajo analiza la configuración de los personajes femeninos
inmigrantes y transmigrantes en las obras “La han despedido de nuevo” de Claudia
Hernández y La fila india de Antonio Ortuño y observa los mecanismos de adaptación, las
estrategias y las dinámicas sociales de las que se basan como forma de auto protección o
de cuidado mutuo. Proponemos una lectura de la representación de las mujeres migrantes
como sujetos complejos, activos, dotados de agencia y transgresores como forma de
contrarrestar los imaginarios consolidados por narrativas anteriores en los que los
sujetos femeninos no han tenido protagonismo en su representación o en su estudio.
Palabras clave: Literatura salvadoreña, literatura mexicana, migración, violencia,
género.
Load Balancing Algorithm of API Gateway Based on Microservice Architecture for a Smart City
Authors: Cao Xiaoming , Zhang Huabing , Shi Hongyu 
Published: January 2024

Abstract
As the entrance of the computer systems, the API gateway is an indispensable part of the microservice architecture. To realize the load balancing of API gateway, this paper studies the load balancing algorithm of the API gateway based on the microservice architecture. In doing this, we analyze the microservice architecture level from the data layer, the basic layer, and other levels, take the container cloud as the carrier of the microservice architecture, combine it with the client and API gateway, and design the API gateway based on the microservice architecture. We then judge whether the microservice identifier in the request source of the API gateway client is included in the API gateway routing table and determine the service cluster to which the microservice belongs according to the microservice identifier. After retrieving the qualified backend microservice container list according to the service cluster information, it adopts a load balancing algorithm based on dynamic weight, takes central processing unit (CPU) utilization and memory utilization as parameters to evaluate the resource load of microservers, uses an extreme gradient lifting model to predict CPU utilization and memory utilization, calculates the weight of microservers based on the prediction results, selects the microserver with the highest weight value to make API gateway service requests, and initiates API gateway service calls to specific backend microservice containers, thereby completing the load balancing of the API gateway. The experimental results show that the average load balancing degree of the algorithm is about 95 %, the average network resource utilization rate is as high as 89 %, and the algorithm execution time is short.
Enhancing Mechanical Properties of PC/ABS Compound through Compatibilizers and Investigation of Morphology and Flammability of the Improved Compound: A Comprehensive Study
Authors: Mostaani Farzaneh , Khosravi SeyyedSajjad , Jalilian Milad 
Published: January 2024

Abstract
This work investigates the effect of four different compatibilizers on the mechanical and thermal properties (impact, tensile strength, elongation, flexural modulus, and heat deflection temperature) of polycarbonate (PC)/acrylonitrile-butadiene-styrene (ABS) blends. The compatibilizers studied were styrene-ethylene-butylene-styrene (SEBS) grafted (g) with maleic anhydride (MAH), polystyrene (PS)-g-MAH, ABS-g-MAH, and ethylene-vinyl acetate (EVA)-g-MAH. The compatibility of the improved sample was also studied using scanning electron microscope images. In addition, the flammability of the improved sample with 8 % decabromodiphenyl ethane (DBDPE) as a flame-retardant (FR) additive was measured by limiting oxidation index and UL 94. The blends with a 70/30 ratio of PC/ABS and varying percentages of compatibilizers (1, 3, and 6 %) were prepared using a twin-screw extruder, and samples for mechanical tests were produced by injection molding. The mechanical properties indicated that PS-g-MAH was better than other compatibilizers. Compared with pure PC and ABS, the PC30P3-FR blend was an economical and versatile compound with potential applications in the electrical and electronic industries.
Comparative analysis of essential oil containing raw materials of honeyherb (Lippia dulcis Trevir.) under different growing conditions
Authors: Marchyshyn Svitlana , Slobodianiuk Liudmyla , Budniak Liliia , Dakhym Iryna , Boyko Larysa , Kyryliv Mariia , Bekus Iryna 
Published: January 2024

The use of plant raw materials is one of the areas of modern pharmaceutical science in the production of herbal drugs. In this regard, one of the oldest medicinal plants, Lippia dulcis Trevir (Phyla scaberrima (Juss. ex Pers.) Moldenke) from Verbenaceae family, is of great interest. According to traditional Mexican medicine, Lippia dulcis is used in the treatment of colds, coughs, bronchitis, and digestive disorders as an anti-inflammatory, antitussive, antipyretic, expectorant, emollient and diuretic agent.
The aim. The aim of our study was to identify and determine the quantitative content of essential oils by GC/MS method in Lippia dulcis herb shoots.
Materials and methods. The determination of the essential oil composition of Lippia dulcis was conducted using Agilent Technologies' 6890 chromatograph with mass spectrometric detector 5973 (Agilent Technologies, USA).
Results. The GC/MS method 19 components of essential oil were identified in L. dulcis shoots grown in open soil conditions, the total content of which was 1274.82 μg/g, in L. dulcis shoots grown in closed soil conditions - 23, the total content of which was 2361.11 μg/g. Thus, the total content of essential oil in shoots of L. dulcis grown in closed soil conditions was 1.8 times higher than in shoots of L. dulcis grown in open soil conditions.
Conclusions. The component composition of the essential oil of L. dulcis shoots harvested from plants grown in open soil conditions (LD-1) and closed soil conditions (LD-2) was investigated using the chromato-mass spectrometric method. The following pharmacologically important components - camphor, germacrene D, caryophyllene, α-bisabolene - were found in both samples of the essential oil of L. dulcis shoots in significant quantities, which indicates the prospects for further technological and pharmacological studies of honey herb raw materials