bluuebunny/crossref_metadata_2025_split huggingface dataset:
Context‐based generic cross‐lingual retrieval of documents and automated summaries
Authors: Lam Wai , Chan Ki , Radev Dragomir , Saggion Horacio , Teufel Simone 
Published: November 2004

AbstractWe develop a context‐based generic cross‐lingual retrieval model that can deal with different language pairs. Our model considers contexts in the query translation process. Contexts in the query as well as in the documents based on co‐occurrence statistics from different granularity of passages are exploited. We also investigate cross‐lingual retrieval of automatic generic summaries. We have implemented our model for two different cross‐lingual settings, namely, retrieving Chinese documents from English queries as well as retrieving English documents from Chinese queries. Extensive experiments have been conducted on a large‐scale parallel corpus enabling studies on retrieval performance for two different cross‐lingual settings of full‐length documents as well as automated summaries.
The utility of mixed‐effects covariate analysis in rapid selection of doses in pediatric subjects: A case study with fexofenadine hydrochloride
Authors: Krishna Rajesh , Krishnaswami Sriram , Kittner Barbara , Sankoh Abdul J. , Jensen Bradford K. 
Published: November 2004

AbstractFexofenadine hydrochloride is a non‐sedating antihistamine that is used in the treatment of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria. A pooled analysis of pharmacokinetic data from children 6 months to 12 years of age and adults was conducted to identify the dose(s) in children that produce exposures comparable to those in adults for the treatment of seasonal allergic rhinitis. The pharmacokinetic parameter database included peak and overall exposure data from 269 treatment exposures from 136 adult subjects, and 90 treatment exposures from 77 pediatric allergic rhinitis patients. The data were pooled and analysed using NONMEM software, version 5.0. A covariate model based on body weight and age and a power function model based on body weight were identified as appropriate models to describe the variability in fexofenadine oral clearance and peak concentration, respectively. Individual oral clearance estimates were on average 44%, 36% and 61% lower in children 6 to 12 years (n = 14), 2 to 5 years (n = 21), and 6 months to 2 years (n = 42), respectively, compared with adults. Trial simulations (n = 100) were carried out based on the final pharmacostatistical models and parameter estimates to identify the appropriate dose(s) in children relative to the marketed dose of 60 mg fexofenadine hydrochloride in adults. The trials were designed as crossover studies in 18 subjects comprising various potential dosing regimens with and without weight stratification. Pharmacokinetic parameter variability was assumed to have a log‐normal distribution. Individual weights and ages were simulated using mean (SD) estimates derived from the studies used in this analysis and proportional measurement/model mis‐specification errors derived from the analysis were incorporated into the simulation. The results indicated that a 30 mg dose of fexofenadine hydrochloride administered to children 1 to 12 years of age and weighing >10.5 kg and a 15 mg dose administered to children 6 months and older and weighing ⩽10.5 kg produces exposures similar to those seen with the 60 mg dose in adults. Copyright © 2004 John Wiley & Sons, Ltd.
Clerical child sex abuse: the response of the Roman Catholic Church
Authors: Dunne Elizabeth A. 
Published: November 2004

AbstractThe response of the Roman Catholic Church (RCC) to the clergy child sex abuse crisis is examined in the context of six cases in an Irish archdiocese. The RCC was not proactive in engaging with complainants and did not accept organizational responsibility for its personnel. Its statements on the crisis were abstract and sometimes transcendent in tone and its attempts to account for its inaction used apologia rather than apology. The Church's reliance on apologia is similar to that found in secular bureaucracies that believe themselves to be ‘client‐independent’. It is argued the Church needs to implement a ‘client complaint’ procedure similar to that found in ‘client‐dependent’ commercial enterprises and that it must also reconnect with its own core values. Copyright © 2004 John Wiley & Sons, Ltd.
Action research, emancipation and design thinking
Authors: Romme A. Georges L. 
Published: November 2004

AbstractThis article evaluates the notion and practice of action research, as defined by contributors to the recent special issue ‘Action Research and Emancipation’ in this journal. The author argues that, although action research implicitly has a design orientation, it largely draws on the humanities and sciences as its main role models. As a result, action researchers nowadays do not see themselves as design professionals. Idealized design methods serve to illustrate how design research can help realize the emancipatory intentions of action researchers. Copyright © 2004 John Wiley & Sons, Ltd.
Rendering natural waters taking fluorescence into account
Authors: Cerezo By E. , Seron F. J. 
Published: November 2004

AbstractThe aim of the work presented here is to generalize a system, developed to treat general participating media, to make it capable of considering volumetric inelastic processes such as fluorescence. Our system, based on the discrete ordinates method, is adequate to treat a complex participating medium such as natural waters as it is prepared to deal with not only anisotropic but also highly peaked phase functions, as well as to consider the spectral behaviour of the medium's characteristic parameters. It is also able to generate detailed quantitative illumination information, such as the amount of light that reaches the medium boundaries or the amount of light absorbed in each of the medium voxels. First, we present an extended form of the radiative transfer equation to incorporate inelastic volumetric phenomena. Then, we discuss the necessary changes in the general calculation scheme to include inelastic scattering. We have applied all this to consider the most common inelastic effect in natural waters: fluorescence in chlorophyll‐a. Copyright © 2004 John Wiley & Sons, Ltd.
Motion Panoramas
Authors: Bartoli Adrien , Dalal Navneet , Horaud Radu 
Published: November 2004

AbstractIn this paper we describe a method for analysing video sequences and for representing them as mosaics or panoramas. Previous work on video mosaicking essentially concentrated on static scenes. We generalize these approaches to the case of a rotating camera observing both static and moving objects where the static portions of the scene are not necessarily dominant, as it has been often hypothesized in the past. We start by describing a robust technique for accurately aligning a large number of video frames under unknown camera rotations and camera settings. The alignment technique combines a feature‐based method (initialization and refinement) with rough motion segmentation followed by a colour‐based direct method (final adjustment). This precise frame‐to‐frame alignment allows the dynamic building of a background representation as well as an efficient segmentation of each image such that moving regions of arbitrary shape and size are aligned with the static background. Thus a motion panorama visualizes both dynamic and static scene elements in a geometrically consistent way. Extensive experiments applied to archived videos of track‐and‐field events validate the approach. Copyright © 2004 John Wiley & Sons, Ltd.
A comparison of four stent designs on arterial injury, cellular proliferation, neointima formation, and arterial dimensions in an experimental porcine model
Authors: Taylor Allen J. , Gorman Patrick D. , Kenwood Bruce , Hudak Craig , Tashko Gerti , Virmani Renu 
Published: November 2004

AbstractThe stent‐artery interactions of different stent designs have implications for their clinical effects. We studied four different stent designs to compare their effects on arterial injury, cellular proliferation, neointima formation, and arterial dimensions. Eighteen nonatherosclerotic miniswine underwent random placement of 52 coronary stents (3.0 mm), including self‐expanding nitinol stents (no postdilation; Radius, n = 13) and balloon‐expandable stents (8 atm × 45 sec; Palmaz‐Schatz, n = 13; BX, n = 12; and Multilink, n = 14). Cellular proliferation was determined by S‐phase labeling with BrdU at 7, 14, and 28 days. Proliferation, injury scores, and arterial morphometry were blindly evaluated. All four stent designs had similar injury scores, cellular proliferation indexes (neointimal and medial), and adventitial areas. Nitinol stents resulted in a twofold increase in neointimal area and thickness in 28‐day vessels (P = 0.002). However, lumen area was similar for all stent designs because of an offsetting expansion in vessel area in nitinol stents (20% greater than balloon‐expandable stents) occurring between 7 and 14 days after stent deployment (P = 0.03). Reduced neointimal cell density in nitinol stents (20% less than balloon‐expandable stents, P = 0.012) suggests that extracellular matrix expansion accounts for the larger neointima in nitinol stents. Self‐expansion of nitinol stents within normal porcine arteries results in a similar degree of arterial injury compared to balloon‐expandable stent designs. Progressive enlargement of nitinol stents between 7 and 14 days after deployment is associated with the development of a larger, matrix‐rich neointima, with a preserved lumen area. Cathet Cardiovasc Intervent 2001;53:420–425. Published 2001 Wiley‐Liss, Inc.
Cutting balloon angioplasty for treatment of calcified coronary lesions
Authors: Karvouni Evangelia , Stankovic Goran , Albiero Remo , Takagi Takuro , Corvaja Nicola , Vaghetti Marco , Di Mario Carlo , Colombo Antonio 
Published: November 2004

AbstractThe aim of the study was to evaluate the feasibility, safety, and efficacy of cutting balloon angioplasty in treatment of angiographically moderate and severe calcified coronary lesions. Thirty‐seven calcified coronary lesions (29 patients) detected by angiography were dilated with cutting balloon. Predilatation with plain balloon was performed in 27 (73.0%) lesions and stent was implanted in 23 (62.2%) lesions following cutting balloon. Acute gain following cutting balloon in predilated lesions was compared to the acute gain following plain balloon predilatation. For predilated lesions, acute gain after cutting balloon was significantly greater compared with plain balloon predilatation (1.51 ± 0.49 vs. 0.77 ± 0.42; P = 0.01). This result was achieved with larger size and lower pressure of cutting balloon compared with plain balloon (3.28 ± 0.46 vs. 2.94 ± 0.55, P = 0.01; 10.38 ± 1.64 vs. 13.19 ± 3.63, P = 0.001, respectively). The final gain following cutting balloon dilatation was significantly higher than the expected gain obtained by using a plain balloon of the same size (1.51 ± 0.49 vs. 0.93 ± 0.48; P < 0.0001), which was inflated at significantly higher pressure compared with cutting balloon. When we compared acute gain following cutting balloon in lesions with and without predilatation, we found no significant difference (P = 0.31). Angiographic success was achieved in 36 (97.3%) lesions and procedural success in 33 (89.1%) lesions. In‐hospital major adverse cardiac event (MACE) occurred in three (10.3%) patients. Follow‐up MACE was reported from three (10.3%) patients. In conclusion, cutting balloon angioplasty is feasible and safe in treatment of angiographically moderate and severe calcified lesions. Dilating efficiency of cutting balloon seems to be greater compared with a plain balloon of the same size, which was inflated at significantly higher pressure compared with cutting balloon. These results can be achieved with low in‐hospital MACE and are associated with a good long‐term outcome. Cathet Cardiovasc Intervent 2001;54:473–481. © 2001 Wiley‐Liss, Inc.
Formation of a Novel Type of Reverse Microemulsion System and Its Application in Synthesis of the Nanostructured La0.95Ba0.05MnAl11O19 Catalyst.
Authors: Teng Fei , Xu Jinguang , Tian Zhijian , Wang Junwei , Xu Yunpeng , Xu Zhusheng , Xiong Guoxing , Lin Liwu 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Properties of Azoles and Their Derivatives. Part 52. Periselectivity of [2 + 3] Cycloaddition of Nitrones to trans‐β‐Cyanonitroethylene in the Light of FMO Theory.
Authors: Jasinski R. , Ciezkowska A. , Baranski A. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reactions of Cyclopropyl Aryl Ketones with Sulfonamides Mediated by Zr(OTf)4: Cascade Preparation of 5‐Aryl‐3,4‐dihydro‐2H‐pyrrole.
Authors: Shi Min , Yang Yong‐Hua , Xu Bo 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Oxidative ipso‐Fluorination of para‐Substituted Phenols Using Pyridinium Polyhydrogen Fluoride in Combination with Hypervalent Iodine(III) Reagents.
Authors: Karam Omar , Martin‐Mingot Agnes , Jouannetaud Marie‐Paule , Jacquesy Jean‐Claude , Cousson Alain 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Development of Highly Diastereo‐ and Enantioselective Direct Asymmetric Aldol Reaction of a Glycinate Schiff Base with Aldehydes Catalyzed by Chiral Quaternary Ammonium Salts.
Authors: Ooi Takashi , Kameda Minoru , Taniguchi Mika , Maruoka Keiji 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Direct Preparation of Allylic Indium(III) Reagents from Allylic Alcohols via a Reductive Transmetalation of π‐Allylnickel(II) with Indium(I) Iodide.
Authors: Hirashita Tsunehisa , Kambe Shinya , Tsuji Hiromitsu , Omori Hideki , Araki Shuki 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enzyme Catalyzed Hydroxymethylation of Aromatic Aldehydes with Formaldehyde. Synthesis of Hydroxyacetophenones and (S)‐Benzoins.
Authors: Demir Ayhan S. , Ayhan Peruze , Igdir A. Cigdem , Duygu A. Nese 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Facile Conversion of Aryl Alkyl Ketones into Methyl 2‐Arylalkanoates Using Poly[4‐(diacetoxyiodo)styrene].
Authors: Sheng Shou‐Ri , Zhong Ming‐Hua , Liu Xiao‐Ling , Luo Qiu‐Yan , Chen Hui‐Zong 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Aryl Perfluoroalkyl Sulfides from Aromatic Disulfides.
Authors: Sipyagin A. M. , Enshov V. S. , Kashtanov S. A. , Potemkin V. A. , Thrasher J. S. , Waterfeld A. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Pressure Control of Diastereodifferentiating [2 + 2] Photocycloaddition of (E)‐Stilbene to Chiral Fumarate upon Direct and Charge‐Transfer Excitation.
Authors: Saito Hideaki , Mori Tadashi , Wada Takehiko , Inoue Yoshihisa 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Tandem Free‐Radical Cyclization Reaction of Alkylenecyclopropanes: A Novel and Efficient Method for the Preparation of 2‐(3,4‐Dihydronaphthalen‐2‐yl)malonic Acid Diethyl Esters.
Authors: Zhou Hongwei , Huang Xian , Chen Wanli 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Benzofurans from Isovanillin via C‐Propenylation‐o‐Vinylation and Ring‐Closing Metathesis.
Authors: Tsai Tzu‐Wei , Wang Eng‐Chi , Huang Keng‐Shiang , Li Sie‐Rong , Wang You‐Feng , Lin Yu‐Li , Chen Yung‐Hua 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiproliferative Activity of 3‐Aryl‐2‐[1H(2H)‐benzotriazol‐1(2)‐yl]acrylonitriles Variously Substituted. Part 4.
Authors: Carta Antonio , Palomba Michele , Boatto Gianpiero , Busonera Bernardetta , Murreddu Marta , Loddo Roberta 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Synthesis of 10‐Aryl‐2,7‐dimethyl‐4,5‐dioxo‐3,6,9‐trioxa‐3,4,5,6,9,10‐hexahydroanthra cene Catalyzed by KF‐Alumina.
Authors: Feng Youjian , Gao Yuan , Zhu Songlei , Li Tuanjie , Zhang Xiaojing , Tu Shujiang , Shi Daqing 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Photochemically Catalyzed Diels—Alder Reaction of N‐Arylimines by 2,4,6‐Triphenylpyrylium Salt: Synthesis of Furo‐ and Pyranoquinoline Derivatives.
Authors: Zhang Wei , Guo Yanping , Yang Li , Liu Zhong‐Li 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Synthesis of 2‐ and 3‐Substituted‐2,3‐dihydro[1,4]dioxino[2,3‐b]pyridine Derivatives.
Authors: Lazar S. , Soukri M. , Leger J. M. , Jarry C. , Akssira M. , Chirita R. , Grig‐Alexa I. C. , Finaru A. , Guillaumet G. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantioselective Synthesis of (+)‐Nuciferal, (+)‐(E)‐Nuciferol and (+)‐α‐Curcumene by Chiral Hydrogenesterification Reaction.
Authors: Du Zhenting , Yue Guoren , Ma Junying , She Xuegong , Wu Tongxing , Pan Xinfu 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of Quaternary α‐ and β‐Amino Acids and β‐Lactams via Proline‐Catalyzed Mannich Reactions with Branched Aldehyde Donors.
Authors: Chowdari Naidu S. , Suri Jeff T. , Barbas Carlos F. III 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Polymer‐Bound Diphenylphosphane Hydrobromide, a Mild Acid for the Activation of Enol Ethers: Applications in Polymer‐Assisted Glycosidations.
Authors: Jaunzems Janis , Kashin Dmitri , Schoenberger Andreas , Kirschning Andreas 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Concise Asymmetric Synthesis of (‐)‐Halosaline and (2R,9aR)‐(+)‐2‐Hydroxy‐quinolizidine by Ruthenium‐Catalyzed Ring‐Rearrangement Metathesis.
Authors: Lesma Giordano , Crippa Sergio , Danieli Bruno , Passarella Daniele , Sacchetti Alessandro , Silvani Alessandra , Virdis Andrea 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Structure—Affinity Relationships of 5′‐Aromatic Ethers and 5′‐Aromatic Sulfides as Partial A1 Adenosine Agonists, Potential Supraventricular anti‐Arrhythmic Agents.
Authors: Morrison Christopher F. , et al. et al. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel δ2‐Isoxazolines as Group II Phospholipase A2 Inhibitors.
Authors: Basappa Basappa , Kumar M. Satish , Swamy S. Nanjunda , Mahendra M. , Prasad J. Shashidhara , Viswanath B. S. , Rangappa K. S. 
Published: November 2004

AbstractFor Abstract see ChemInform Abstract in Full Text.
Intratumoral administration of a 1,2‐dimyristyloxypropyl‐3‐ dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine formulation of the human interleukin‐2 gene in the treatment of metastatic renal cell carcinoma
Authors: Galanis Evanthia , Burch Patrick A. , Richardson Ronald L. , Lewis Bradley , Pitot Henry C. , Frytak Stephen , Spier Catherine , Akporiaye Emmanuel T. , Peethambaram Prema P. , Kaur Judith S. , Okuno Scott H. , Unni Krishnan K. , Rubin Joseph 
Published: November 2004

AbstractBACKGROUNDLeuvectin (Vical Inc., San Diego, CA) is a gene transfer product in which a plasmid encoding the human interleukin‐2 (IL‐2) gene is complexed with the cationic lipid 1,2‐dimyristyloxypropyl‐3‐dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine (DMRIE/DOPE). In the current study, the authors investigated the safety and efficacy of in situ vaccination with Leuvectin in patients with metastatic renal cell carcinoma.METHODSThirty‐one patients with metastatic renal cell carcinoma were treated with intratumorally administered Leuvectin at doses ranging from 0.75 to 4 mg. These patients subsequently were evaluated for response and for treatment‐related toxicity.RESULTSTreatment was well tolerated: no Grade 3 or 4 toxicities were observed in association with the study agent. Documented side effects included Grade 1 pain at the injection site (20%); mild (i.e., Grade 1 or 2) constitutional symptoms, including malaise/myalgia, low‐grade fever, and chills (74%); Grade 1 fatigue (19%); Grade 1 or 2 nausea (10%); and Grade 2 allergy (1 occurrence). Two patients experienced partial responses, which endured for 32 months and 6 years, respectively, and 1 patient currently is experiencing a pathologic complete response, which, to date, has persisted for 50 months; thus, the overall response rate was 10%. In addition, 7 patients (23%) experienced disease stabilization for a median of 8 months (range, 4–48 months). The median duration of survival from the start of Leuvectin treatment was 11 months (range, 2–72 months), with a 1‐year survival rate of 48% and a 3‐year survival rate of 19%. Laboratory analysis of tumor samples revealed the presence of IL‐2 plasmid DNA in six of eight patients posttreatment, increased IL‐2 expression in tumor cells in four of eight patients posttreatment, and increased tumor infiltration by CD8‐positive lymphocytes in five of eight patients posttreatment.CONCLUSIONSImmunotherapy with intratumorally administered Leuvectin is safe and can lead to durable objective responses in patients with metastatic renal cell carcinoma. Cancer 2004. © 2004 American Cancer Society.
Expression of the pro‐apoptotic protein ARTS in astrocytic tumors
Authors: Gottfried Yossi , Voldavsky Eugene , Yodko Lena , Sabo Edmond , Ben‐Itzhak Ofer , Larisch Sarit 
Published: November 2004

AbstractBACKGROUNDApoptosis (i.e., programmed cell death) plays a major role in the development of astrocytic tumors, which are the most common tumors of the central nervous system. ARTS, a proapoptotic protein that is localized in the mitochondria, promotes apoptosis by functioning as an XIAP antagonist and a caspase activator.METHODSTo investigate the role of ARTS in astrocytoma, the authors examined protein expression and apoptotic activity in 72 astrocytic tumors, which included low‐grade astrocytomas, anaplastic astrocytomas, and glioblastomas.RESULTSWhereas normal astrocytes did not express the ARTS protein, astrocytoma cells strongly expressed ARTS, and the expression of this protein increased with increasing tumor grade. Furthermore, increased levels of ARTS were significantly associated with higher rates of apoptosis (as measured using the terminal deoxynucleotidyltransferase–mediated deoxyuridine triphosphate nick end‐labeling [TUNEL] assay as well as an immunohistochemical staining assay for active caspase‐3) in these tumors. Levels of two other apoptosis‐related proteins, p53 and Bcl‐2, also were examined using immunohistochemical methods; ARTS expression was found to be positively correlated with expression of the former and negatively correlated with expression of the latter, which is known to possess antiapoptotic activity.CONCLUSIONSThe results of the current study suggest that ARTS levels reliably reflect the ability of cells to undergo apoptosis, which serves as a defense mechanism against the development and progression of astrocytoma. Furthermore, ARTS expression, when taken into consideration in combination with tumor grade, was the only independent predictor of survival identified in the current analysis. Thus, the authors conclude that ARTS may possess utility as a prognostic marker, as well as a therapeutic tool, for patients with astrocytoma. Cancer 2004. © 2004 American Cancer Society.