bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inverted U-shaped relationship between coffee consumption and serum uric acid in American chronic kidney disease population
Authors: Song Jianling , Li Hong , Fang Xiangdong 
Published: November 2023

ObjectiveThe objective of this study was to examine the contentious relationship between coffee consumption and serum uric acid (SUA) levels, specifically within American population with chronic kidney disease (CKD).MethodsA total of 23,381 participants from the 2001–2018 National Health and Nutrition Examination Survey (NHANES) were selected for inclusion in this investigation. Linear regression models and generalized additive models with smooth curve fitting were employed to analyze the association between log coffee consumption and serum uric acid levels. Furthermore, the robustness of the findings was assessed across diverse populations.ResultsThe results of the linear regression analysis indicate a positive and marginally statistically significant (p = 0.0307) association between log coffee consumption and SUA, even after controlling for other variables. Furthermore, the generalized additive model revealed a nonlinear relationship characterized by an inverted U-shape between log coffee consumption and SUA. The inflection point, identified as 11.43 g/day, marks the point at which this relationship changes direction. Moreover, this inverted U-shaped relationship was consistently observed across various subgroups, including gender, age (&lt;60 and ≥ 60 years), hypertensive and non-hypertensive individuals, those with and without cardiovascular disease, non-diabetic individuals, and those who consumed coffee with or without caffeine or sugar.ConclusionAn inverse U-shaped correlation has been observed between log coffee consumption and SUA levels. This finding implies that once coffee consumption surpasses a specific threshold, it promotes a decline in SUA levels.
Harnessing the translational power of bleomycin model: new insights to guide drug discovery for idiopathic pulmonary fibrosis
Authors: Murgo Annalisa , Bignami Fabio , Federico Giuseppina , Villetti Gino , Civelli Maurizio , Sala Angelo , Miglietta Daniela 
Published: November 2023

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, age-related interstitial lung disease (ILD) with limited therapeutic options. Despite the wide variety of different in vivo models for IPF, these preclinical models have shown limitations that may significantly impair their translational potential. Among the most relevant limitations are the methodologies used to assess the efficacy of anti-fibrotic treatments, that are not the ones used in humans. In this scenario, the goal of the work presented in this paper is to provide translational relevance to the bleomycin (BLM)-induced pulmonary fibrosis mouse model, introducing and validating novel readouts to evaluate the efficacy of treatments for IPF.Methods: The BLM model was optimized by introducing the use of functional assessments such as the Forced Vital Capacity (FVC) and the Diffusion Factor for Carbon Monoxide (DFCO), that are respectively the primary and secondary endpoints in clinical trials for IPF, comparing them to more common readouts such as lung histology, improved by the application of Artificial Intelligence (AI) to detect and quantify fibrotic tissue deposition, and metalloproitenase-7 (MMP-7), a clinical prognostic biomarker.Results: Lung function measurement and DFCO changes well correlated with Ashcroft score, the current gold-standard for the assessment of pulmonary fibrosis in mice. The relevance and robustness of these novel readouts in the BLM model was confirmed by the results obtained testing Nintedanib and Pirfenidone, the only drugs approved for the treatment of IPF patients: in fact, both drugs administered therapeutically, significantly affected the changes in these parameters induced by BLM treatment, with results that closely reflected the efficacy observed in the clinic. Changes in biomarkers such as MMP-7 were also evaluated, and well correlated with the modifications of FVC and DFCO.Conclusion: Novel functional readouts such as FVC and DFCO can be efficiently used to assess pathology progression in the BLM-induced pulmonary fibrosis mouse model as well as compound efficacy, substantially improving its translational and predictivity potential.
Future expectation levels of adolescents during the COVID-19 pandemic
Authors: Küçükkelepçe Osman , Parlak Mehmet Emin , Öz Erdoğan , Kapıcı Yaşar , Ener Dilek 
Published: November 2023

IntroductionThis study was aimed at examining the future expectations of high school students during the COVID-19 pandemic.MethodsA future expectation questionnaire was administered to 412 high school students, and the change in their expectations for the future during the COVID-19 pandemic period was questioned in this questionnaire.ResultsScale sub-scores and total scores of those who were infected with COVID-19 were significantly lower than those who were not (p &lt; 0.001). The scale sub-scores and total scores of those whose relatives were infected with COVID-19 were significantly lower than those who were not (p &lt; 0.05). The scale sub-scores and total scores of those who think that the pandemic will always continue, those who think that their education is disrupted due to the pandemic, those who think that the pandemic affects their choice of profession, and those who express that they look to the future with more hope than before the pandemic were found to be significantly lower (p &lt; 0.05).DiscussionThe future expectation is a more sensitive concept among adolescents than adults. During and after the pandemic, activities should be organized by considering the sensitivity of young people about their future expectations, and families and society should be made aware of this issue.
Admission rates and clinical profiles of children and youth with eating disorders treated as inpatients before and during the COVID-19 pandemic in a German university hospital
Authors: Silber Ann-Sophie , Platte Simeon , Kumar Afsheen , Arora Sukhdeep , Kadioglu Dennis , Schmidt Marvin , Storf Holger , Chiocchetti Andreas G. , Freitag Christine M. 
Published: November 2023

IntroductionChildren and youth at risk for mental health disorders, such as eating disorders (ED), were particularly affected by the COVID-19 pandemic, yet evidence for the most seriously affected and thus hospitalized youth in Germany is scarce.MethodsThis crosssectional study investigated anonymized routine hospital data (demographic information, diagnoses, treatment modalities) of patients admitted (n = 2,849) to the Department of Child and Adolescence Psychiatry, Psychosomatics and Psychotherapy (DCAPPP) of a German University Hospital between 01/2016 and 02/2022. Absolute and relative number of inpatients with or without ED prior to (01/2016–02/2020) and during the COVID-19 pandemic (03/2020–02/2022) were compared. The effect of school closures as part of social lockdown measures for COVID-19 mitigation on inpatient admission rate was explored as it has been discussed as a potential risk factor for mental health problems in youth.ResultsDuring the COVID-19 pandemic, ED inpatient admission rate increased from 10.5 to 16.7%, primarily driven by Anorexia Nervosa (AN). In contrast to previous reports, we found no change in somatic and mental disorder comorbidity, age or sexratio for hospitalized youth with ED. However, we did observe a shortened length of hospital stay (LOS) for hospitalized youth with and without ED. In addition, non-ED admissions presented with an increased number of mental disorder comorbidities. In contrast to our hypothesis, school closures were not related to the observed increase in ED.DiscussionIn summary, the COVID-19 pandemic was associated with an increased rate of inpatient treatment for youth suffering from AN, and of youth affected by multiple mental disorders. Accordingly, we assume that inpatient admission was prioritized for individuals with a higher burden of disease during the COVID-19 pandemic. Our findings pinpoint the need for adequate inpatient mental health treatment capacities during environmental crises, and a further strengthening of child and adolescence psychiatry services in Germany.
Exploring the Nexus of lower extremity proprioception and postural stability in older adults with osteoporosis: a cross-sectional investigation
Authors: Ahmad Irshad , Reddy Ravi Shankar , Alqhtani Raee S. , Tedla Jaya Shanker , Dixit Snehil , Ghulam Hussain Saleh H. , Alyami Abdullah Mohammed , Al Adal Saeed , Jarrar Mohammad A. M. 
Published: November 2023

BackgroundOsteoporosis, characterized by reduced bone mass and micro-architectural deterioration, poses a significant public health concern due to increased fracture susceptibility. Beyond bone health, this cross-sectional study aimed to assess and compare lower extremity proprioception and postural stability in individuals with and without osteoporosis and to explore their correlation within the osteoporosis group.MethodIn this prospective cross-sectional study, 80 participants were divided into two groups: osteoporosis (n = 40) and control (n = 40). The demographic characteristics and clinical parameters of the participants were as follows: Age (years) – Osteoporosis group: 65.04 ± 4.33, Control group: 65.24 ± 4.63; Sex (%) – Osteoporosis group: Male 30%, Female 70%; Control group: Male 30%, Female 70%; Body mass index (kg/m2) – Osteoporosis group: 23.7 ± 3.2, Control group: 24.5 ± 4.6; T-score (Lumbar) – Osteoporosis group: −2.86 ± 1.23, Control group: 0.27 ± 0.58; T-score (hip) – Osteoporosis group: −2.28 ± 0.79, Control group: 0.68 ± 0.86. Joint Position Sense (JPS) at the hip, knee, and ankle was assessed using a digital inclinometer, and postural stability was measured using computerized force platforms.ResultOsteoporosis participants exhibited higher errors in hip (5.63° vs. 2.36°), knee (4.86° vs. 1.98°), and ankle (4.46° vs. 2.02°) JPS compared to controls. Postural stability measures showed increased anterior–posterior sway (10.86 mm vs. 3.98 mm), medial-lateral sway (8.67 mm vs. 2.89 mm), and ellipse area (966.88 mm2 vs. 446.19 mm2) in osteoporosis participants. Furthermore, correlation analyses within the osteoporosis group unveiled significant positive associations between lower extremity proprioception and postural stability. Specifically, hip JPS exhibited a strong positive correlation with anterior–posterior sway (r = 0.493, p = 0.003), medial-lateral sway (r = 0.485, p = 0.003), and ellipse area (r = 0.496, p &lt; 0.001). Knee JPS displayed a moderate positive correlation with anterior–posterior sway (r = 0.397, p = 0.012), medial-lateral sway (r = 0.337, p = 0.032), and ellipse area (r = 0.378, p &lt; 0.001). Similarly, ankle JPS showed a moderate positive correlation with anterior–posterior sway (r = 0.373, p = 0.023), medial-lateral sway (r = 0.308, p = 0.045), and ellipse area (r = 0.368, p = 0.021).ConclusionThese findings underscore the interplay between proprioceptive deficits, compromised postural stability, and osteoporosis, emphasizing the need for targeted interventions to improve fall prevention strategies and enhance the quality of life for individuals with osteoporosis.
UPAYA KEBERLANJUTAN DESAIN PADA RAK PAJANG MENGGUNAKAN METODE ATUMICS
Authors: Wismoyo Erlana Adli , Hadiansyah Mahendra Nur , Muarrafah Annisa , Kurnia Dewanti Anggun , Nursetyo Raudinahaq Syarafina , Nursa’adah Silvy Amelia 
Published: November 2023

Penelitian ini bertujuan untuk memaparkan solusi desain untuk rak pajang pada toko sembako dengan menggunakan metode atumics dengan mempertimbangkan keberlanjutan desain. Keberlanjutan desain merupakan upaya yang dibuat untuk mengatasi kondisi serta dampak negatif dalam sebuah krisis lingkungan, kesehatan, kenyamanan pengguna, dan sebagai salah satu upaya pengembangan desain agar dapat sesuai dengan aktivitas manusia. Penelitian ini mencoba untuk mengatasi permasalahan dari salah satu elemen ruang, yaitu furnitur berupa rak pajang toko sembako yang digunakan untuk menyimpan kebutuhan toko dan memajang produk jual, menggunakan model atumics. Model atumics merupakan penggabungan unsur tradisi dan unsur furnitur modern melalui penyatuan dari eksisting produk lama dan beberapa referensi desain yang didapat sehingga membentuk desain keberlanjutan. Penelitian ini menggunakan metode kualitatif dengan mengolah data hasil observasi dan studi literatur. Hasil penelitian ini diharapkan menjadi landasan dari terciptanya sebuah inovasi furnitur baru dengan desain yang lebih umum sehingga dapat didistribusikan dalam pasar yang lebih luas. Dengan bentuk dan ukuran yang lebih kecil dan mudah untuk dapat disesuaikan dengan keadaan pasar yang ada. Tidak hanya digunakan dalam sebuah retail toko sembako, furnitur juga dapat diletakkan dalam toko retail lainnya hingga rumah tinggal sebagai tempat penyimpanan.
Planning the activities of a metallurgical company based on the integration of S&OP and CPFR
Authors: Chernikova O. P. , Tushev A. A. 
Published: November 2023

Supply chain management of large metallurgical companies is complicated by working in conditions of risk and high uncertainty of activity. The traditional planning system does not allow for sufficient consistency and synchronization of the plans of structural units with each other and with the external environment of interaction. Based on the analysis of the economic planning management of the leading companies in the industry, it was found that the integrated planning system of the company currently contributes to solving these problems. The authors propose its formation based on the use of two information practices: S&OP (sales and operations planning) and CPFR (collaborative planning, forecasting, and replenishment with trading partners).Planning the activities of a metallurgical company based on the integration of S&OP and CPFR will allow: to increase the accuracy of forecasts of demand for the range of products offered; to more effectively manage the stocks of raw materials, rolled products and metal products; to improve coordination between the functional areas of the company; to provide flexibility in production planning.At the same time, the transformation of the planning and economic practice of a metallurgical company should take into account the risks of emerging difficulties in collecting and exchanging big data with counterparties, errors in forecasting indicators, as well as coordination of plans between integration participants, restructuring of business processes and organizational cultures of partners.
El Martín Fierro como causa justa
Authors: Montaldo Graciela 
Published: November 2023

Este artículo explora las funciones del poema de José Hernández dentro de la institución literaria, considerando las tensiones que el autor mismo experimenta con la obra al problematizar cuestiones centrales a la literatura: el realismo, la ficción, la representación. En ese marco, se enfoca principalmente en dos tópicos. El primero es la idea de “intraducible” (B. Cassin), que quiere indagar cómo la lengua del Martín Fierro funciona como un lugar de opacidad y resistencia a las prácticas literarias (a la vez que se incluye en la institución). Para ello, se estudian algunos casos de “traducción” del poema y la explicitación de los problemas que entraña.
El segundo tópico se centra en la idea de archivo y canon, y estudia cómo el Martín Fierro se comporta en una literatura como la argentina, que se reescribe y que lo adopta tempranamente como clásico. La hipótesis del artículo sostiene que el poema de Hernández, en sus numerosas reescrituras, no se comportó solo como un precursor, sino que la obra generó un relato maestro a través de una historia de rebeldía y negociación. Ese relato dirige buena parte de aquellas producciones posteriores que reescribieron el clásico.
Respon Agronomi Padi Gogo lokal Sulawesi Tenggara pada Berbagai Kondisi Lingkungan Tumbuh
Authors: Sanjaya Muhammad Fahyu , Afa La Ode , M Amir , Utami Rahmawati Ning 
Published: November 2023

AbstrakPadi (Oryza sativa L.) merupakan komoditi utama dalam menyediakan sumber karbohidrat di Indonesia. Produktivitas budidaya tanaman padi selalu terkendala pada ketersediaan air, karena mayoritas padi dibudidayakan pada kondisi lahan basah irigasi, sehingga membutuhkan banyak pasokan air. Kondisi ini membuat budidaya padi hanya dapat dilakukan satu musim tanam per tahun sedangkan kebutuhan masyarakat terhadap beras terus meningkat, untuk itu perlu adanya pengujian tanaman padi gogo lokal yang dapat memenuhi kebutuhan musim tanam baik dalam kondisi lingkungan kering maupun lahan basah. Penelitian ini bertujuan untuk mengetahui respon agronomi tanaman padi gogo lokal Sultra dilahan kering dan lahan basah serta adanya sumber genetik baru untuk pengembangan padi yang berproduksi tinggi pada berbagai lingkungan tumbuh. Penelitian ini dilaksanakan di Lahan Percobaan Fakultas Pertanian Universitas Halu Oleo. Rancangan penelitian menggunakan rancangan acak kelompok dengan perlakuan Rancangan Petak Terpisah. Petakan Utama ialah Lahan Basah dan Lahan Kering. Anakan Petak ialah kultivar padi gogo lokal Sultra. Masing-masing perlakuan diulang sebanyak 3 ulangan. Hasil pengamatan dianalisis menggunakan sidik ragam, jika F-Hitung menunjukan pengaruh nyata atau sangat nyata maka dilanjutkan dengan uji lanjut Duncan pada taraf kepercayaan 95%. Hasil penelitian menunjukkan perbedaan nyata antara perlakuan mandiri yang diuji dengan perlakuan lainnya pada variable pengamatan yang diukur dengan kultivar terbaik adalah pae wuna dan Indalibana. Kultivar Pae Wuna dan Indalibana adalah dua kultivar padi gogo lokal Sultra yang memiliki potensi untuk tumbuh baik dalam dua kondisi lahan yang berbeda, sehingga bisa dijadikan sebagai sumber genetik padi yang dapat dikembangkan dalam berbagai lingkungan tumbuh. Kata Kunci: Kultivar, Lahan Kering, Lahan Basah, Padi Gogo
Analisis Hygiene dan Sanitasi Peralatan pada Pedagang Penjual Makanan Jajanan di Pasar Tradisional di Kabupaten Semarang
Authors: Siswanto Yuliaji , Pertiwi Kartika Dian 
Published: November 2023

Hygiene food equipment is one of the important things in determining the quality of a food. Food equipment will have an impact on the quality of the food to be made. Based on data from the Ministry of Health of the Republic of Indonesia, the prevalence of diarrhea in 2018 was 37.88% or around 1,516,438 cases. Food Born Disease is still a public health problem in Indonesia. Food safety is a public need, because safe food will protect and prevent disease or other health problems. This study aims to describe the hygiene and sanitation equipment used by food vendors in traditional markets in Semarang Regency. This research is descriptive in nature by determining the sample using purposive sampling technique, as many as 108 food vendors in traditional markets in Semarang district. Data were obtained using a questionnaire with observation and interview methods, and data were analyzed descriptively. The results of this study indicate that the implementation of hygiene and sanitation for processing and serving food in traditional markets in Semarang Regency does not meet health requirements.
ABSTRAK
Hygiene peralatan makanan menjadi salah satu hal penting dalam menentukan kualitas suatu makanan. Peralatan makanan akan berdampak pada kualitas makanan yang akan dibuat. Berdasarkan data Kementreian Kesehatan Republik Indonesia prevalensi diare pada tahun 2018 sebanyak 37,88% atau sekitar 1.516.438 kasus. Penyakit akibat makanan (Food Born Disease) masih menjadi masalah kesehatan masyarakat di Indonesia. Keamanan makanan merupakan kebutuhan masyarakat, karena makanan yang aman akan melindungi dan mencegah terjadinya penyakit atau gangguan kesehatan lainnya. Penelitian ini bertujuan untuk mengetahui gambaran hygiene sanitasi peralatan yang digunakan pedagang penjual makanan di pasar tradisional di Kabupaten Semarang. Penelitian ini bersifat deskriptif dan sampel diambil dengan teknik Quota Sampling, sebanyak 108 pedagang makanan di Pasar Tradisional di Kabupaten Semarang. Data diperoleh menggunakan kuesioner dengan metode observasi dan wawancara, dan data dianalisis secara deskriptif. Hasil penelitian ini menunjukkan penerapan hygiene dan sanitasi peralatan pengolah dan penyajian makanan jajanan di Pasar Tradisional di Kabupaten Semarang belum memenuhi syarat kesehatan.
PERBANDINGAN DESTRUKSI BASAH DAN KERING DENGAN VARIASI ZAT PENGOKSIDASI PADA ANALISIS TIMBAL DALAM RAMBUT PETUGAS OPERATOR SPBU SECARA AAS
Authors: Talitha Rahma Faisa , Ayu Puspitasari , Lully Hanni Endarini 
Published: November 2023

Lead (Pb) is a heavy metal that can cause poisoning and accumulate in the human body. Determination of lead levels by using AAS the condition is that the sample must be a solution, then it is necessary to destruct first. There are two types of destruction that can be done, namely wet destruction using acid reagents to decompose samples and dry destruction by heating or destruction using very high temperatures. HNO3 oxidizing agent and HNO3 mixture with HClO4 are the main oxidizing agents that can provide the best destructive results compared to other oxidizing agents. This study aims to determine the best oxidizing and destructive substances present in the hair using Atomic Absorption Spectrophotometry (AAS). The research was conducted at surabaya regional health laboratory in April - May 2021. This research is comparative research. The sample used is the hair of gelam gas station operator officer, Candi. There are two ways of preparing samples that can be done in pb analysis on hair, namely proses wet and dry destruction. The result of destruction is determined by the level of lead using Atomic Absorption Spectrophotometry (AAS). The results of the analysis pno dry destructionHNO3 as a whole has rentang lead levels 0.1281-0.1958 mg / L. Dry destruction HNO3 : HClO4 secara overall has rentang lead levels 0.1457-0.2159 mg /L. HNO3 closed wet construction has lead content range 0.1431-0.2034 mg/L and wet destructive closed HNO3 : HClO4 has lead content range 0.1080-0.5371 mg/L. Based on these results, it can be known that all hair samples tested in this study contain lead levels that are still within normal limits or within the tolerance limit of < 12 μg/g.
PERSEPSI PETANI CABAI TERHADAP PEMBIAYAAN BERBASIS TEKNOLOGI DI KECAMATAN KABANDUNGAN, KABUPATEN SUKABUMI
Authors: Khoirunnisa Nida'a , Karyani Tuti 
Published: November 2023

Cabai merupakan salah satu komoditas sayuran yang berkontribusi dalam menyumbang PDB. Provinsi Jawa Barat termasuk salah satu daerah yang memproduksi cabai dan Kecamatan Kabandungan Kabupaten Sukabumi merupakan daerah yang petaninya aktif melakukan usaha tani cabai. Dalam menjalankan usaha tani, permasalahan mendasar yang sering dihadapi petani adalah keterbatasan modal. Financial technology (fintech) sebagai produk dari keuangan dan layanan permodalan yang baru diharapkan dapat memberikan kemudahan kepada petani dalam mengakses modal dan mendorong kemajuan teknologi di pembiayaan pertanian. Sebagai lembaga keuangan, fintech memiliki karakteristik produk dan layanan yang berbeda dengan lembaga keuangan konvensional. Penelitian ini bertujuan untuk mengidentifikasi persepsi petani cabai di Kecamatan Kabandungan terhadap pembiayaan berbasis teknologi. Analisis data yang digunakan dalam penelitian ini adalah analisis statistik deskriptif, skala likert, dan Cross Tabulation. Hasil penelitian menunjukkan bahwa mayoritas petani setuju dengan pernyataan persepsi harapan kinerja, harapan usaha, pengaruh sosial, dan kondisi fasilitas pendukung.