bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network analysis of physical activity and depressive and affective symptoms during COVID-19 home confinement
Authors: Cecchini José A. , Carriedo Alejandro , Méndez-Giménez Antonio , Fernández-Río Javier 
Published: October 2023

Abstract
Introduction: The aim of this study was to analyze the network structure of physical activity, frequency, depressive, and affective symptoms in people under home isolation due to COVID-19. Method: A longitudinal study was conducted in two phases (beginning (March 19, 2020) and end of home confinement (April 8, 2020)). The sample consisted of 579 participants from Spain (250 men and 329 women) aged 16 to 92 years (overall sample: M = 47.06, SD = 14.52). A network analysis was performed. Results: Four clusters emerged (PA, depressive symptoms, positive affect, and negative affect). A higher frequency of physical activity was related to better-sustained attention, increased alertness, and enthusiasm. In addition, feelings of guilt and shame were mitigated, and confinement distress and irritability were reduced. Physical activity also mitigated fatigue in women, whereas feelings of unhappiness were reduced in men. Conclusion: Physical activity seems to be an effective option for mitigating the negative effects of the COVID-19 pandemic. Public health policymakers should develop programs to promote physical activity in order to be able to cope with confinement or similar scenarios in the future.
Computational theories should be made with natural language instead of meaningless code
Authors: DeScioli Peter 
Published: October 2023

Abstract
The target article claims that we should speak in code to understand property, because natural language is too ambiguous. Yet the best computer programmers tell us the opposite: Arbitrary code is too ambiguous, so we should use natural language for variables, functions, and classes. I discuss how meaningless code makes Boyer's theory too enigmatic to properly debate.
Primordial feeling of possession in development
Authors: Rochat Philippe 
Published: October 2023

Abstract
Boyer's minimalist model of human ownership psychology overlooks important cues that children provide in their development leading them from pre-conceptual to conceptual (symbolic) expressions of the basic feeling experience of control over things, qua ownership in the most basic psychological sense. Appeal for innate core knowledge and evolutionary logic blows out the light of this rich and unique ontogenetic progression.
Reciprocal contracts – not competitive acquisition – explain the moral psychology of ownership
Authors: André Jean-Baptiste , Fitouchi Léo , Baumard Nicolas 
Published: October 2023

Abstract
We applaud Boyer's attempt to ground the psychology of ownership partly in a cooperative logic. In this commentary, we propose to go further and ground the psychology of ownership solely in a cooperative logic. The predictions of bargaining theory, we argue, completely contradict the actual features of ownership intuitions. Ownership is only about the calculation of mutually beneficial, reciprocal contracts.
No single notion of cooperation explains when we respect ownership
Authors: Fonn Erik Kjos , Zahl Joakim Haugane , Kristensen Bjørn Dahl , Margoni Francesco , Thomsen Lotte 
Published: October 2023

Abstract
Cooperation is fundamentally moderated by the form of relationship between the actors involved, as is normative resource distribution. We argue that possessions are likely treated differently across different types of cooperative relationships. Whereas Boyer's computational model might in principle account for this, the theory would benefit from a specification of how different cooperative contexts can shape the representation of ownership.
Boyer's minimal model should also represent multiple ownership without collective agency
Authors: Umbreș Radu 
Published: October 2023

Abstract
Boyer's minimal model of ownership psychology suggests that joint possession triggers representations of collective agency. However, many forms of co-ownership based on cooperation or competition can be represented as a set of P() or L() tags without inferring a unifying collective entity. Moreover, representations of partible ownership are required to engage in cooperative production and distribution of resources.
Not by intuitions alone: Institutions shape our ownership behaviour
Authors: Blazsek Reka , Heintz Christophe 
Published: October 2023

AbstractEvery day, people make decisions about who owns what. What cognitive processes produce this? The target article emphasises the role of biologically evolved intuitions about competition and cooperation. We elaborate the role of cultural evolutionary processes for solving coordination problems. A model based fully on biological evolution misses important insights for explaining the arbitrariness and historical contingency in ownership beliefs.
Clinical impact of COVID-19 in patients with carbapenem-resistant Acinetobacter baumannii bacteraemia
Authors: Kim Jeong Yeon , Lee Woo Joo , Suh Jin Woong , Kim Sun Bean , Sohn Jang Wook , Yoon Young Kyung 
Published: October 2023

Abstract
The aim of this study was to evaluate the impact of coronavirus disease 2019 (COVID-19) on treatment outcomes in critically ill patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infection (BSI). This single-centre, retrospective cohort study was conducted in a 1,048-bed university-affiliated tertiary hospital in the Republic of Korea from January 2021 to March 2022. The study participants included consecutive hospitalised adult patients (aged ≥18 years) in the intensive care unit with CRAB monomicrobial BSI. During the study period, a total of 70 patients were included in our study, and 24 (34.3%) were diagnosed with COVID-19. The 28-day mortality rate was 64.3%. In the multivariate Cox proportional hazard regression analysis, diagnosis of COVID-19 (hazard ratio (HR), 2.91; 95% confidence interval (CI): 1.45–5.87), neutropenia (HR, 2.76; 95% CI: 1.04–7.29), Pitt bacteraemia score (per point; HR, 1.30; 95% CI: 1.19–1.41), and appropriate definite antibiotic therapy (HR, 0.31; 95% CI: 0.15–0.62) were independent predictors of 28-day mortality in patients with CRAB BSI. In conclusion, our findings suggested that COVID-19 has a negative prognostic impact on patients with CRAB BSI. Further study is needed to investigate the specific mechanisms of how COVID-19 worsens the prognosis of CRAB infection.
Understanding the complexity of individual developmental pathways: A primer on metaphors, models, and methods to study resilience in development
Authors: Hasselman Fred 
Published: October 2023

AbstractThe modern study of resilience in development is conceptually based on a complex adaptive system ontology in which many (intersystem) factors are involved in the emergence of resilient developmental pathways. However, the methods and models developed to study complex dynamical systems have not been widely adopted, and it has recently been noted this may constitute a problem moving the field forward. In the present paper, I argue that an ontological commitment to complex adaptive systems is not only possible, but highly recommended for the study of resilience in development. Such a commitment, however, also comes with a commitment to a different causal ontology and different research methods. In the first part of the paper, I discuss the extent to which current research on resilience in development conceptually adheres to the complex systems perspective. In the second part, I introduce conceptual tools that may help researchers conceptualize causality in complex systems. The third part discusses idiographic methods that could be used in a research program that embraces the interaction dominant causal ontology and idiosyncratic nature of the dynamics of complex systems. The conclusion is that a strong ontological commitment is warranted, but will require a radical departure from nomothetic science.
Alfvén‐Fast Wave Coupling in a 2D Nonuniform Medium
Authors: Davies R. , Wright A. N. 
Published: October 2023

AbstractA 2D Cartesian simulation is presented and used to solve the ideal, low‐beta, linear magnetohydrodynamics equations. A simulation is used to investigate the propagation of Alfvén waves through inhomogeneities in Alfvén speed and density. In particular, the loss of Alfvén wave energy through coupling to the fast wave, and also the form of the Alfvén wave as it emerges from the inhomogeneous region is studied. Potential applications of this include the magnetospheres of both Jupiter and the Earth. The results show that Alfvén waves can be significantly distorted by a nonuniformity and still propagate through the region efficiently, with relatively small amounts of Alfvén wave energy lost through mode conversion and reflection.
A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy
Authors: Hutka Barbara , Várallyay Anett , László Szilvia B. , Tóth András S. , Scheich Bálint , Paku Sándor , Vörös Imre , Pós Zoltán , Varga Zoltán V. , Norman Derek D. , Balogh Andrea , Benyó Zoltán , Tigyi Gábor , Gyires Klára , Zádori Zoltán S. 
Published: October 2023

AbstractLysophosphatidic acid (LPA) is a bioactive phospholipid mediator that has been found to ameliorate nonsteroidal anti-inflammatory drug (NSAID)-induced gastric injury by acting on lysophosphatidic acid type 2 receptor (LPAR2). In this study, we investigated whether LPAR2 signaling was implicated in the development of NSAID-induced small intestinal injury (enteropathy), another major complication of NSAID use. Wild-type (WT) and Lpar2 deficient (Lpar2−/−) mice were treated with a single, large dose (20 or 30 mg/kg, i.g.) of indomethacin (IND). The mice were euthanized at 6 or 24 h after IND treatment. We showed that IND-induced mucosal enteropathy and neutrophil recruitment occurred much earlier (at 6 h after IND treatment) in Lpar2−/− mice compared to WT mice, but the tissue levels of inflammatory mediators (IL-1β, TNF-α, inducible COX-2, CAMP) remained at much lower levels. Administration of a selective LPAR2 agonist DBIBB (1, 10 mg/kg, i.g., twice at 24 h and 30 min before IND treatment) dose-dependently reduced mucosal injury and neutrophil activation in enteropathy, but it also enhanced IND-induced elevation of several proinflammatory chemokines and cytokines. By assessing caspase-3 activation, we found significantly increased intestinal apoptosis in IND-treated Lpar2−/− mice, but it was attenuated after DBIBB administration, especially in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice. Finally, we showed that IND treatment reduced the plasma activity and expression of autotaxin (ATX), the main LPA-producing enzyme, and also reduced the intestinal expression of Lpar2 mRNA, which preceded the development of mucosal damage. We conclude that LPAR2 has a dual role in NSAID enteropathy, as it contributes to the maintenance of mucosal integrity after NSAID exposure, but also orchestrates the inflammatory responses associated with ulceration. Our study suggests that IND-induced inhibition of the ATX-LPAR2 axis is an early event in the pathogenesis of enteropathy.
Generation of evidence-based carboplatin dosing guidelines for neonates and infants
Authors: Barnett Shelby , Makin Guy , Tweddle Deborah A. , Osborne Caroline , Veal Gareth J. 
Published: October 2023

Abstract
Background
To optimally dose childhood cancer patients it is essential that we apply evidence-based dosing approaches. Carboplatin is commonly dosed to achieve a cumulative target exposure (AUC) in children, with target AUC values of 5.2–7.8 mg/ml.min defined. To achieve these exposures patients are dosed at 6.6 mg/kg/day or 4.4 mg/kg for patients <5 kg. The current study uses real world clinical pharmacology data to optimise body weight-based doses to effectively target AUCs of 5.2–7.8 mg/ml.min in infants.

Methods
Carboplatin exposures were determined across 165 treatment cycles in 82 patients ≤10 kg. AUC and clearance values were determined by Bayesian modelling from samples collected on day 1. These parameters were utilised to assess current dosing variability, determine doses required to achieve target AUC values and predict change in AUC using the modified dose.

Results
No significant differences in clearance were identified between patients <5 kg and 5–10 kg. Consequently, for patients <5 kg, 4.4 mg/kg dosing was not sufficient to achieve a target AUC of 5.2 mg/ml.min, with <55% of patients within 25% of this target. Optimised daily doses for patients ≤10 kg were 6 mg/kg and 9 mg/kg for cumulative carboplatin target exposures of 5.2 and 7.8 mg/ml.min, respectively.

Conclusions
Adoption of these evidence-based carboplatin doses in neonates and infants will reduce drug exposure variability and positively impact treatment.
Nystagmus in children with primary brain tumours in Denmark between 2007 and 2017
Authors: Rosenberg Jacqueline Gremaud , Nissen Kamilla , Heegaard Steffen , Ragunathan Suganiah , Schmiegelow Kjeld , Mathiasen René , von Holstein Sarah Linea 
Published: October 2023

Abstract
Background
The aim of the study was to evaluate the prevalence, clinical characteristics, and diagnostic importance of nystagmus in children with brain tumours.

Methods
A nation-wide retrospective review of all children diagnosed with a brain tumour between January the 1st, 2007 and December 31st, 2017, in Denmark. Data is based on information from the Danish Childhood Cancer Registry, hospital records from paediatric- and ophthalmological departments, and records from private ophthalmologists.

Results
Nystagmus was observed in 13.7% (60/437) of children with a brain tumour. In 50/60 children (83.3%) nystagmus was an incidental finding at the clinical examination and only in 10/60 children (16,7%) were nystagmus noticed by patient/caregivers prior to the clinical examination. In 38/60 children nystagmus was observed before the brain tumour diagnosis, most often (16/38, 42%) the same day as the diagnosis was made. In 22/60 children nystagmus was found after the brain tumour diagnosis (prior to any treatment) with a median of four days (range 0-47) after the brain tumour diagnosis. Nystagmus was most commonly binocular (56/60, 93.3%) and gaze-evoked (43/60, 71.7%). The median number of additional symptoms and/or clinical findings was five (range 0–11).

Conclusion
Nystagmus is frequent in children with brain tumours and is typically accompanied by other symptoms and clinical signs. However, nystagmus is often first recognized by the ophthalmologist late in the time course. Therefore, raising awareness of the importance of looking for nystagmus in children with unspecific neurological symptoms might contribute to increased suspicion of brain tumour and thereby faster diagnosis.
Management of functional outcomes after radical prostatectomy in the Nordic countries: A survey of uro-oncological centers
Authors: Nolsøe Alexander Bjørneboe , Holm Henriette Veiby , Murtola Teemu J. , Østergren Peter Busch , Fode Mikkel 
Published: October 2023

AbstractWe aimed to describe the clinical practice regarding erectile dysfunction and urinary incontinence after radical prostatectomy in the Nordic countries. A 37-item survey about pre- and post-prostatectomy evaluation and rehabilitation of sexual and urinary function was sent to 42 uro-oncology centers. Reporting was done according to the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Twenty-seven centers in Denmark (n = 6), Norway (n = 8), Finland (n = 7), and Sweden (n = 6) responded (64.3%). Post-prostatectomy sexual function was evaluated by 25 centers. The majority used validated questionnaires with significant variations across centers. Post-prostatectomy urinary function was evaluated by 24 centers. Again, the majority used validated questionnaires, while 9 centers used objective measures including uroflowmetry, residual urine volume, and pad usage. Twenty-one centers offered sexual rehabilitation and 12 of these described their protocols. All centers administered phosphodiesterase-5 inhibitors and seven centers offered further treatment options. Two centers offered a consultation with a sexologist. Twenty-three centers provided pelvic floor muscle training and one center used medical support with duloxetine. Our study indicates a need for standardized evaluation and management of erectile dysfunction and urinary incontinence following radical prostatectomy. Especially, there is a need for an increased focus on comprehensive sexual rehabilitation.
Natural killer cell activity in metastatic castration resistant prostate cancer patients treated with enzalutamide
Authors: Zedan A. H. , Nederby L. , Volmer L. M. , Madsen C. V. , Sørensen B. E. , Hansen T. F. 
Published: October 2023

AbstractMetastatic castration resistant prostate cancer (mCRPC) is still the lethal stage for the whole spectrum of prostate cancer disease. Even though different treatment options have been introduced in the last decade with a significant survival improvement for this population, a lack of more reliable prognostic and predictive markers is still one of the main clinical challenges in management of mCRPC. The aim of this study was to investigate the correlation between Natural Killer cell activity (NKA) and both treatment effect and outcomes in patients with mCRPC treated with enzalutamide. A total of 87 patients with mCRPC treated with enzalutamide as the first line treatment were enrolled. NKA was estimated at baseline and prior to each treatment cycle. Endpoints included both treatment effect with biochemical response (BR), biochemical progression (BP) and radiological progression (RP), as well as outcome data with overall survival (OS), radiologic progression free survival (rPFS), and time to next treatment (TTT). At the time of BR, interferon-gamma (IFNγ) decreased significantly compared to levels detected at baseline (z-score = 2.33, p = 0.019). Regarding outcome data, the whole cohort was divided into four groups according to the change of IFNγ level during the first 3 cycles of enzalutamide treatment. In group 1 (n = 42) the IFNγ level remained within a normal range (≥ 250 pg/mL),while in group 2 (n = 7) it increased from an abnormal (< 250 pg/mL) to a normal level. In group 3 (n = 13) it dropped to an abnormal level, and it remained at an abnormal level during treatment in group 4 (n = 17). Patients in group 2 showed the worst prognosis with shorter both rPFS and TTT (HR 4.30, p = 0.037; and HR 6.82, p = 0.011, respectively). In this study inverse correlations between NKA and both treatment response and outcomes was observed in mCRPC patients receiving enzalutamide, suggesting an unfavourable role of NK cells in the late stage of PCa.
Shifts of the soil microbiome composition induced by plant–plant interactions under increasing cover crop densities and diversities
Authors: Newberger Derek R. , Minas Ioannis S. , Manter Daniel K. , Vivanco Jorge M. 
Published: October 2023

AbstractInterspecific and intraspecific competition and facilitation have been a focus of study in plant-plant interactions, but their influence on plant recruitment of soil microbes is unknown. In this greenhouse microcosm experiment, three cover crops (alfalfa, brassica, and fescue) were grown alone, in paired mixtures, and all together under different densities. For all monoculture trials, total pot biomass increased as density increased. Monoculture plantings of brassica were associated with the bacteria Azospirillum spp., fescue with Ensifer adhaerens, and alfalfa with both bacterial taxa. In the polycultures of cover crops, for all plant mixtures, total above-ground alfalfa biomass increased with density, and total above ground brassica biomass remained unchanged. For each plant mixture, differential abundances highlighted bacterial taxa which had not been previously identified in monocultures. For instance, mixtures of all three plants showed an increase in abundance of Planctomyces sp. SH-PL14 and Sandaracinus amylolyticus which were not represented in the monocultures. Facilitation was best supported for the alfalfa-fescue interaction as the total above ground biomass was the highest of any mixture. Additionally, the bulk soil microbiome that correlated with increasing plant densities showed increases in plant growth-promoting rhizobacteria such as Achromobacter xylosoxidans, Stentotrophomonas spp., and Azospirillum sp. In contrast, Agrobacterium tumefaciens, a previously known generalist phytopathogen, also increased with alfalfa-fescue plant densities. This could suggest a strategy by which, after facilitation, a plant neighbor could culture a pathogen that could be more detrimental to the other.
Validation of an on-chip p16ink4a/Ki-67 dual immunostaining cervical cytology system using microfluidic device technology
Authors: Hashimoto Kei , Kumagai Tomoo , Nomura Kyosuke , Miyagawa Yuko , Tago Saori , Takasaki Kazuki , Takahashi Yuko , Nishida Haruka , Ichinose Takayuki , Hirano Mana , Hiraike Haruko , Wada-Hiraike Osamu , Sasajima Yuko , Kim Soo Hyeon , Nagasaka Kazunori 
Published: October 2023

AbstractMore specific screening systems for cervical cancer may become necessary as the human papillomavirus (HPV) vaccine becomes more widespread. Although p16/Ki-67 dual-staining cytology has several advantages, it requires advanced diagnostic skills. Here, we developed an automated on-chip immunostaining method using a microfluidic device. An electroactive microwell array (EMA) microfluidic device with patterned thin-film electrodes at the bottom of each microwell was used for single-cell capture by dielectrophoresis. Immunostaining and dual staining for p16/Ki-67 were performed on diagnosed liquid cytology samples using the EMA device. The numbers of p16/Ki-67 dual-stained cells captured by the EMA device were determined and compared among the cervical intraepithelial neoplasia (CIN) lesion samples. Seven normal, fifteen CIN grade 3, and seven CIN grade 2 samples were examined. The percentage of dual-positive cells was 18.6% in the CIN grade 2 samples and 23.6% in the CIN grade 3 samples. The percentages of dual-positive staining increased significantly as the severity of the cervical lesions increased. p16/Ki67 dual immunostaining using the EMA device is as sensitive as the conventional method of confirming the histopathological diagnosis of cervical samples. This system enables a quantified parallel analysis at the individual cell level.