bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimated Glomerular Filtration Rate and Implantable Cardioverter‐Defibrillator in Nonischemic Systolic Heart Failure: Extended Follow‐Up of DANISH
Authors: Doi Seiko N. , Thune Jens Jakob , Nielsen Jens C. , Haarbo Jens , Videbæk Lars , Yafasova Adelina , Bruun Niels E. , Gustafsson Finn , Eiskjær Hans , Hassager Christian , Svendsen Jesper H. , Høfsten Dan E. , Torp‐Pedersen Christian , Pehrson Steen , Køber Lars , Butt Jawad H. 
Published: January 2024

Background
Patients with heart failure and chronic kidney disease (CKD) may have an increased risk of death from causes competing with arrhythmic death, which could have implications for the efficacy of implantable cardioverter‐defibrillators (ICDs). We examined the long‐term effects of primary prophylactic ICD implantation, compared with usual care, according to baseline CKD status in an extended follow‐up study of DANISH (Danish Study to Assess the Efficacy of ICDs in Patients With Nonischemic Systolic Heart Failure on Mortality).

Methods and Results

In the DANISH trial, 1116 patients with nonischemic heart failure with reduced ejection fraction were randomized to receive an ICD (N=556) or usual care (N=550). Outcomes were analyzed according to CKD status (estimated glomerular filtration rate ≥/<60 mL/min per 1.73 m
2
) at baseline. In total, 1113 patients had an available estimated glomerular filtration rate measurement at baseline (median estimated glomerular filtration rate 73 mL/min per 1.73 m
2
), and 316 (28%) had CKD. During a median follow‐up of 9.5 years, ICD implantation, compared with usual care, did not reduce the rate of all‐cause mortality (no CKD, HR, 0.82 [95% CI, 0.64–1.04]; CKD, HR, 1.02 [95% CI, 0.75–1.38];
P
interaction
=0.31) or cardiovascular death (no CKD, HR, 0.77 [95% CI, 0.58–1.03]; CKD, HR, 1.05 [95% CI, 0.73–1.51];
P
interaction
=0.20), irrespective of baseline CKD status. Similarly, baseline CKD status did not modify the beneficial effects of ICD implantation on sudden cardiovascular death (no CKD, HR, 0.57 [95% CI, 0.32–1.00]; CKD, HR, 0.65 [95% CI, 0.34–1.24];
P
interaction
=0.70).

Conclusions
ICD implantation, compared with usual care, did not reduce the overall mortality rate, but it did reduce the rate of sudden cardiovascular death, regardless of baseline kidney function in patients with nonischemic heart failure with reduced ejection fraction.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00542945.
Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress
Authors: Jochems Angela C. C. , Muñoz Maniega Susana , Clancy Una , Arteaga Carmen , Jaime Garcia Daniela , Chappell Francesca M. , Hewins Will , Locherty Rachel , Backhouse Ellen V. , Barclay Gayle , Jardine Charlotte , McIntyre Donna , Gerrish Iona , Kampaite Agniete , Sakka Eleni , Valdés Hernández Maria , Wiseman Stewart , Bastin Mark E. , Stringer Michael S. , Thrippleton Michael J. , Doubal Fergus N. , Wardlaw Joanna M. 
Published: January 2024

BackgroundWhite matter hyperintensities (WMHs) might regress and progress contemporaneously, but we know little about underlying mechanisms. We examined WMH change and underlying quantitative magnetic resonance imaging tissue measures over 1 year in patients with minor ischemic stroke with sporadic cerebral small vessel disease.Methods and ResultsWe defined areas of stable normal‐appearing white matter, stable WMHs, progressing and regressing WMHs based on baseline and 1‐year brain magnetic resonance imaging. In these areas we assessed tissue characteristics with quantitative T1, fractional anisotropy (FA), mean diffusivity (MD), and neurite orientation dispersion and density imaging (baseline only). We compared tissue signatures cross‐sectionally between areas, and longitudinally within each area. WMH change masks were available for N=197. Participants' mean age was 65.61 years (SD, 11.10), 59% had a lacunar infarct, and 68% were men. FA and MD were available for N=195, quantitative T1 for N=182, and neurite orientation dispersion and density imaging for N=174. Cross‐sectionally, all 4 tissue classes differed for FA, MD, T1, and Neurite Density Index. Longitudinally, in regressing WMHs, FA increased with little change in MD and T1 (difference estimate, 0.011 [95% CI, 0.006–0.017]; −0.002 [95% CI, −0.008 to 0.003] and −0.003 [95% CI, −0.009 to 0.004]); in progressing and stable WMHs, FA decreased (−0.022 [95% CI, −0.027 to −0.017] and −0.009 [95% CI, −0.011 to −0.006]), whereas MD and T1 increased (progressing WMHs, 0.057 [95% CI, 0.050–0.063], 0.058 [95% CI, 0.050 –0.066]; stable WMHs, 0.054 [95% CI, 0.045–0.063], 0.049 [95% CI, 0.039–0.058]); and in stable normal‐appearing white matter, MD increased (0.004 [95% CI, 0.003–0.005]), whereas FA and T1 slightly decreased and increased (−0.002 [95% CI, −0.004 to −0.000] and 0.005 [95% CI, 0.001–0.009]).ConclusionsQuantitative magnetic resonance imaging shows that WMHs that regress have less abnormal microstructure at baseline than stable WMHs and follow trajectories indicating tissue improvement compared with stable and progressing WMHs.
Thrombolytic Treatment in Wake‐Up Stroke: A Propensity Score–Matched Analysis of Treatment Effectiveness in the Norwegian Stroke Registry
Authors: Søyland Mary‐Helen , Tveiten Arnstein , Eltoft Agnethe , Øygarden Halvor , Varmdal Torunn , Indredavik Bent , Mathiesen Ellisiv B. 
Published: January 2024

Background
Previous clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake‐up stroke (WUS) selected by advanced imaging techniques. The authors assessed the effectiveness of thrombolytic treatment in patients with WUS in a nationwide stroke registry.

Methods and Results

Using propensity score matching, the authors assessed the effectiveness and safety of thrombolytic treatment versus no thrombolytic treatment in 726 patients (363 matched pairs) with WUS in the Norwegian Stroke Registry in 2014 to 2019. Thrombolytic treatment in WUS versus known‐onset stroke was compared in 730 patients (365 matched pairs). Functional outcomes were assessed by the modified Rankin Scale (mRS) at 3 months. A significant benefit of thrombolytic treatment in WUS was seen in ordinal analysis (odds ratio [OR], 1.48 [95% CI, 1.15–1.91];
P
=0.003) and for mRS 0 to 2 (OR, 1.81 [95% CI, 1.29–2.52];
P
=0.001) but not for mRS 0 or 1 (OR, 1.32 [95% CI, 1.00–1.74];
P
=0.050). The proportion of patients with mRS 0 or 1 was lower in patients with WUS who underwent thrombolysis versus those with known‐onset stroke (50.4% versus 59.5%; OR, 0.69 [95% CI, 0.52–0.93];
P
=0.013), while outcomes were similar between groups for mRS 0 to 2 and ordinal analysis. Symptomatic intracranial hemorrhage after thrombolytic treatment occurred in 4.4% of patients with WUS and 3.9% of patients with known‐onset stroke (OR, 1.14 [95% CI, 0.54–2.41];
P
=0.726).

Conclusions
Thrombolytic treatment in patients with WUS was associated with improved functional outcome compared with patients with no thrombolytic treatment and was not associated with increased rates of symptomatic intracranial hemorrhage compared with known‐onset stroke. The results indicate that thrombolytic treatment is effective and safe in WUS in a real‐life setting.
Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization Study
Authors: Salih Ahmed M. , Galazzo Ilaria Boscolo , Menegaz Gloria , Altmann André 
Published: January 2024

Background
Existing research demonstrates the association of shorter leukocyte telomere length with increased risk of age‐related health outcomes including cardiovascular diseases. However, the direct causality of these relationships has not been definitively established. Cardiovascular aging at an organ level may be captured using image‐derived phenotypes of cardiac anatomy and function.

Methods and Results

In the current study, we use 2‐sample Mendelian randomization to assess the causal link between leukocyte telomere length and 54 cardiac magnetic resonance imaging measures representing structure and function across the 4 cardiac chambers. Genetically predicted shorter leukocyte telomere length was causally linked to smaller ventricular cavity sizes including left ventricular end‐systolic volume, left ventricular end‐diastolic volume, lower left ventricular mass, and pulmonary artery. The association with left ventricular mass (
β
=0.217, P
false discovery rate
=0.016) remained significant after multiple testing adjustment, whereas other associations were attenuated.

Conclusions
Our findings support a causal role for shorter leukocyte telomere length and faster cardiac aging, with the most prominent relationship with left ventricular mass.
Preliminary Views on Yanxinglu Studies
Authors: Qi Yongxiang 
Published: January 2024

Abstract
“Yanxinglu studies” is a field of study dedicated to the research of Yanxinglu (Kor: Yŏnhaengnok), the travel records of Korean diplomatic envoys to China during the Koryŏ and Chosŏn periods. Yanxinglu should be distinguished from travel records of a more general nature and can be further classified as follows: Yanxinglu writings in a broad or a narrow sense; and Yanxinglu writings with a single or multiple titles. This article investigates a number of pertinent questions such as the concept of Yanxinglu itself, the titles of individual travel accounts, the creation and periodization of Yanxinglu writings, the collection and compilation of primary sources and their translation, the creation of databases, and the search for suitable research methods. This analysis shows that it is time to establish “Yanxinglu studies” as an independent field of study in China and to create a scholarly society to guide and coordinate future research efforts.
The “Riben dao ge” and the Sinosphere
Authors: Jin Chengyu 
Published: January 2024

Abstract
The “Riben dao ge” is a well-known poem in the history of East Asian literary exchanges. The poem was written by Sima Guang during his appointment at the Palace Library, expressing his cultural expectations as well as some satirical remarks about Qian Gongfu. The earliest proponent of the theory that the “Riben dao ge” was written by Sima Guang was the Japanese Meiji-era scholar Kusaka Hiroshi, who influenced Yang Shoujing. From the standpoint of cultural history, the “Riben dao ge” is intimately connected to the Edo-era concept of lost and surviving books; Chosŏn’s goodwill missions, moreover, played a vital role in the dissemination of the poem in Japan. The “Riben dao ge’s” many influences across Japan and Chosŏn demonstrated an interest in the Chinese cultural issue of “searching for lost rituals among the people.”
Ketamine for treatment-resistant major depressive disorder: Double-blind active-controlled crossover study
Authors: Glue Paul , Neehoff Shona , Beaglehole Ben , Shadli Shabah , McNaughton Neil , Hughes-Medlicott Natalie J 
Published: January 2024

Background: The N-methyl-D-aspartate antagonist ketamine has rapid onset antidepressant activity in treatment-resistant depression (TRD). Aims: To evaluate mood rating, safety and tolerability data from patients with TRD treated with ketamine and the psychoactive control fentanyl, as part of a larger study to explore EEG biomarkers associated with mood response. Methods: We evaluated the efficacy and safety of intramuscular racemic ketamine in 25 patients with TRD, using a double-blind active-controlled randomized crossover design. Ketamine doses were 0.5 and 1 mg/kg, and the psychoactive control was fentanyl 50 mcg, given at weekly intervals. Results/outcomes: Within 1 h of ketamine dosing, patients reported reduced depression and anxiety ratings, which persisted for up to 7 days. A dose–response profile for ketamine was noted for dissociative side effects, adverse events and changes in blood pressure; however, changes in mood ratings were broadly similar for both ketamine doses. Overall, 14/25 patients (56%) were responders (⩾50% reduction at 24 h compared with baseline) for either ketamine dose for the Hospital Anxiety and Depression Scale (HADS), and 18/25 (72%) were responders for the HADS-anxiety scale. After fentanyl, only 1/25 (HADS-depression) and 3/25 (HADS-anxiety) were responders. Ketamine was generally safe and well tolerated in this population. Conclusions: Our findings add to the literature confirming ketamine’s activity against depressive and anxiety symptoms in patients with TRD.
Role of α1-GABAA receptors in the serotonergic dorsal raphe nucleus in models of opioid reward, anxiety, and depression
Authors: Li Chen , McElroy Bryan D , Phillips Jared , McCloskey Nicholas S , Shi Xiangdang , Unterwald Ellen M , Kirby Lynn G 
Published: January 2024

Background: The serotonin (5-hydroxytryptamine (5-HT))-mediated system plays an important role in stress-related psychiatric disorders and substance abuse. Our previous studies showed that stress and drug exposure can modulate the dorsal raphe nucleus (DRN)-5-HT system via γ-aminobutyric acid (GABA)A receptors. Moreover, GABAA receptor-mediated inhibition of serotonergic DRN neurons is required for stress-induced reinstatement of opioid seeking. Aim/methods: To further test the role of GABAA receptors in the 5-HT system in stress and opioid-sensitive behaviors, our current study generated mice with conditional genetic deletions of the GABAA α1 subunit to manipulate GABAA receptors in either the DRN or the entire population of 5-HT neurons. The GABAA α1 subunit is a constituent of the most abundant GABAA subtype in the brain and the most highly expressed subunit in 5-HT DRN neurons. Results: Our results showed that mice with DRN-specific knockout of α1-GABAA receptors exhibited a normal phenotype in tests of anxiety- and depression-like behaviors as well as swim stress-induced reinstatement of morphine-conditioned place preference. By contrast, mice with 5-HT neuron-specific knockout of α1-GABAA receptors exhibited an anxiolytic phenotype at baseline and increased sensitivity to post-morphine withdrawal-induced anxiety. Conclusions: Our data suggest that GABAA receptors on 5-HT neurons contribute to anxiety-like behaviors and sensitivity of those behaviors to opioid withdrawal.
Comparative study of ventilation techniques with supraglottic airway devices in cats: volume-controlled vs pressure-controlled techniques
Authors: Niyatiwatchanchai Nutawan , Rattanathanya Hathaipat , Thengchaisri Naris 
Published: January 2024

Objectives This study compared the effectiveness of a new supraglottic airway device (SGAD) in cats undergoing anaesthesia using two types of mechanical ventilation: volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV). Methods A total of 13 healthy cats (five male, eight female; median age 2 years [range 1–3]) were randomly allocated to either VCV or PCV. Five tidal volumes (6, 8, 10, 12 and 14 ml/kg) and five peak inspiratory pressures (4, 5, 6, 7 and 8 cmH2O) were randomly applied with a minute ventilation of 100 ml/kg/min. Various parameters, such as blood pressure, gas leakage, end-tidal CO2 (ETCO2) and work of breathing (WOB), were measured while using VCV or PCV. Results The occurrence of hypotension (mean arterial blood pressure <60 mmHg) was slightly less frequent with VCV (38 events, 65 ventilating sessions) than with PCV (40 events, 65 ventilating sessions), but this difference did not reach statistical significance ( P = 0.429). The number of leakages did not differ between the VCV group (3 events, 65 ventilating sessions) and the PCV group (3 events, 65 ventilating sessions) ( P = 1.000). Hypercapnia was identified when using VCV (10 events, 65 ventilating sessions) less frequently than when using PCV (17 events, 65 ventilating sessions), but this difference did not reach statistical significance ( P = 0.194). The study found a significantly higher WOB in the PCV group compared with the VCV group ( P <0.034). Conclusions and relevance The present results suggested that both VCV and PCV can be used with an SGAD during anaesthesia, with VCV preferred for prolonged mechanical ventilation due to its lower workload. Adjusting tidal volume or inspiratory pressure corrects hypercapnia.
Development of a dental diet-tracking mobile app for improved caries-related dietary behaviours: Key features and pilot evaluation of quality
Authors: Goh Charlene Enhui , Zheng Kaiping , Chua Wen Yong , Nguyen Thao , Liu Changshuo , Koh Chun Keat , Lee Gabriel Keng Yan , Tay Chong Meng , Ooi Beng Chin , Wong Mun Loke 
Published: January 2024

ObjectiveDiet significantly contributes to dental decay (caries) yet monitoring and modifying patients’ diets is a challenge for many dental practitioners. While many oral health and diet-tracking mHealth apps are available, few focus on the dietary risk factors for caries. This study aims to present the development and key features of a dental-specific mobile app for diet monitoring and dietary behaviour change to prevent caries, and pilot data from initial user evaluation.MethodsA mobile app incorporating a novel photo recognition algorithm and a localised database of 208,718 images for food item identification was developed. The design and development process were iterative and incorporated several behaviour change techniques commonly used in mHealth. Pilot evaluation of app quality was assessed using the end-user version of the Mobile Application Rating Scale (uMARS).ResultsUser feedback from the beta-testing of the prototype app spurred the improvement of the photo recognition algorithm and addition of more user-centric features. Other key features of the final app include real-time prompts to drive actionable behaviour change, goal setting, comprehensive oral health education modules, and visual metrics for caries-related dietary factors (sugar intake, meal frequency, etc.). The final app scored an overall mean (standard deviation) of 3.6 (0.5) out of 5 on the uMARS scale.ConclusionWe developed a novel diet-tracking mobile app tailored for oral health, addressing a gap in the mHealth landscape. Pilot user evaluations indicated good app quality, suggesting its potential as a useful clinical tool for dentists and empowering patients for self-monitoring and behavioural management.
The 100 Top-Cited Articles on Medial Patellofemoral Ligament: A Bibliometric Analysis and Review
Authors: Panagopoulos Andreas , Giannatos Vasileios , Antzoulas Panagiotis , Lakoumentas John , Raoulis Vasileios , Hantes Michael 
Published: January 2024

Background: The medial patellofemoral ligament (MPFL) has been investigated widely in the past 30 years, resulting in many research achievements in this field. Purpose: To perform a comprehensive bibliometric analysis to evaluate the 100 top-cited articles on the MPFL. Study Design: Cross-sectional study. Methods: We searched the Scopus database in December 2022 using the terms “medial patellofemoral ligament” OR “MPFL.” The search was confined to English-language articles, including technical notes, systematic reviews on clinical outcomes and/or complications, clinical studies, studies regarding complications, and basic science articles (either cadaveric or biomechanical); we excluded letters, case reports, personal opinions, guidelines, editorials, and narrative or other types of reviews. Analysis of the 100 top-cited articles was performed according to total number of citations, average citations per year (ACY), study type, country of origin, journal of publication, affiliated institution, and most published authors. Results: The total number of citations was 16,358 (range of citations per article, 72-692). The majority of articles were published as clinical studies (54%), with cadaveric studies being the second most common (21%). Most studies originated in the United States (32%), with Japan (15%) and Germany (13%) following. The American Journal of Sports Medicine published the majority of the 100 top-cited articles (37/100; 6304 citations) as well as the 10 top-cited articles according to ACY (7/10; mean, 285.14 citations). The most prolific authors were Nomura (8 articles); Burks (6 articles); and Inoue, Sillanpää, and Dreyhaupt (5 articles each). Conclusion: By analyzing the characteristics of the 100 top-cited articles, this study demonstrated that the MPFL is a growing and popular area of research, with the focus varying through timeline trends. Questions regarding MPFL anatomy, isometry, and biomechanics might have been answered adequately, but research regarding optimal fixation technique under various circumstances is still ongoing.
Multivariate pattern analysis: a method and software to reveal, quantify, and visualize predictive association patterns in multicollinear data
Authors: Baumeister Tim U. H. , Aadland Eivind , Linington Roger G. , Kvalheim Olav M. 
Published: January 2024

Abstract
Background
Strongly multicollinear covariates, such as those typically represented in metabolomics applications, represent a challenge for multivariate regression analysis. These challenges are commonly circumvented by reducing the number of covariates to a subset of linearly independent variables, but this strategy may lead to loss of resolution and thus produce models with poorer interpretative potential. The aim of this work was to implement and illustrate a method, multivariate pattern analysis (MVPA), which can handle multivariate covariates without compromising resolution or model quality.

Results
MVPA has been implemented in an open-source R package of the same name, mvpa. To facilitate the usage and interpretation of complex association patterns, mvpa has also been integrated into an R shiny app, mvpaShiny, which can be accessed on www.mvpashiny.org. MVPA utilizes a general projection algorithm that embraces a diversity of possible models. The method handles multicollinear and even linear dependent covariates. MVPA separates the variance in the data into orthogonal parts within the frame of a single joint model: one part describing the relations between covariates, outcome, and explanatory variables and another part describing the “net” predictive association pattern between outcome and explanatory variables. These patterns are visualized and interpreted in variance plots and plots for pattern analysis and ranking according to variable importance. Adjustment for a linear dependent covariate is performed in three steps. First, partial least squares regression with repeated Monte Carlo resampling is used to determine the number of predictive PLS components for a model relating the covariate to the outcome. Second, postprocessing of this PLS model by target projection provided a single component expressing the predictive association pattern between the outcome and the covariate. Third, the outcome and the explanatory variables were adjusted for the covariate by using the target score in the projection algorithm to obtain “net” data. We illustrate the main features of MVPA by investigating the partial mediation of a linearly dependent metabolomics descriptor on the association pattern between a measure of insulin resistance and lifestyle-related factors.

Conclusions
Our method and implementation in R extend the range of possible analyses and visualizations that can be performed for complex multivariate data structures. The R packages are available on github.com/liningtonlab/mvpa and github.com/liningtonlab/mvpaShiny.