bluuebunny/crossref_metadata_2025_split huggingface dataset:
Waste‐to‐Energy: Development of a Highly Efficient Keratin Enhanced Chitosan Bio‐Waste‐Derived Triboelectric Nanogenerator for Energy Harvesting and Real Applications
Authors: Motora Kebena Gebeyehu , Wu Chang‐Mou , Jose Cathlene Roi Mongaya , Rani Gokana Mohana 
Published: January 2024

AbstractIn this study, a novel and sustainable triboelectric material is successfully designed and developed by extracting keratin from recycled fur and combining it with chitosan to create a keratin/chitosan triboelectric nanogenerator (CK‐TENG) device. The device is designed for the simultaneous treatment of waste and the generation of green and clean energy, crucial for addressing global challenges. CK is prepared through a freeze‐drying method to overcome the weak mechanical properties of keratin and achieve a high surface contact area, which is important for triboelectric properties. The results showed that the output voltage is improved by 375% compared to the TENG without keratin, with values reaching 322 V under a 6 N. It produced a high power density of 14.4 W m−2 and excellent cyclic stability for more than 8000 cycles, which are crucial for practical applications. Further, the potential applications are also studied, and the results showed that it can turn on over 250 light‐emitting diodes (LEDs), display liquid crystal display (LCD), and charge capacitors under 6 N. Moreover, it is successful in harvesting energy from waste vibrations, acoustic energy, and as a shoe, and the electrical output is utilized to power electronic devices. Furthermore, the power density harvested by the device is higher than that of TENG devices made with keratin‐rich materials. Therefore, this study paves the way for the use of keratin‐based bio‐waste materials for clean and green energy production, which can play significant roles in applications such as the charging of electronic devices, biomedicine, sensors, and smart textiles.
Dynamic Antimicrobial Poly(disulfide) Coatings Exfoliate Biofilms On Demand Via Triggered Depolymerization
Authors: Lou Yang , Palermo Edmund F. 
Published: January 2024

AbstractBacterial biofilms are notoriously problematic in applications ranging from biomedical implants to ship hulls. Cationic, amphiphilic antibacterial surface coatings delay the onset of biofilm formation by killing microbes on contact, but they lose effectiveness over time due to non‐specific binding of biomass and biofilm formation. Harsh treatment methods are required to forcibly expel the biomass and regenerate a clean surface. Here, a simple, dynamically reversible method of polymer surface coating that enables both chemical killing on contact, and on‐demand mechanical delamination of surface‐bound biofilms, by triggered depolymerization of the underlying antimicrobial coating layer, is developed. Antimicrobial polymer derivatives based on α‐lipoic acid (LA) undergo dynamic and reversible polymerization into polydisulfides functionalized with biocidal quaternary ammonium salt groups. These coatings kill >99.9% of Staphylococcus aureus cells, repeatedly for 15 cycles without loss of activity, for moderate microbial challenges (≈105 colony‐forming units (CFU) mL−1, 1 h), but they ultimately foul under intense challenges (≈107 CFU mL−1, 5 days). The attached biofilms are then exfoliated from the polymer surface by UV‐triggered degradation in an aqueous solution at neutral pH. This work provides a simple strategy for antimicrobial coatings that can kill bacteria on contact for extended timescales, followed by triggered biofilm removal under mild conditions.
Anti‐Inflammatory Peptide‐Conjugated Silk Fibroin/Cryogel Hybrid Dual Fiber Scaffold with Hierarchical Structure Promotes Healing of Chronic Wounds
Authors: Fan Ruyi , Zhao Jiebing , Yi Lei , Yuan Jiayi , McCarthy Alec , Li Bo , Yang Ganghua , John Johnson V. , Wan Wenbing , Zhang Yi , Chen Shixuan 
Published: January 2024

AbstractChronic wounds resulting from diabetes, pressure, radiation therapy, and other factors continue to pose significant challenges in wound healing. To address this, this study introduces a novel hybrid fibroin fibrous scaffold (FFS) comprising randomly arranged fibroin fibers and vertically aligned cryogel fibers (CFs). The fibroin scaffold is efficiently degummed at room temperature and simultaneously formed a porous structure. The aligned CFs are produced via directional freeze‐drying, achieved by controlling solution concentration and freezing polymerization temperature. The incorporation of aligned CFs into the expanded fibroin fiber scaffold leads to enhanced cell infiltration both in vitro and in vivo, further elevating the hybrid scaffold's tissue compatibility. The anti‐inflammatory peptide 1 (AP‐1) is also conjugated to the hybrid fibrous scaffold, effectively transforming the inflammatory status of chronic wounds from pro‐inflammatory to pro‐reparative. Consequently, the FFS‐AP1+CF group demonstrates superior granulation tissue formation, angiogenesis, collagen deposition, and re‐epithelialization during the proliferative phase compared to the commercial product PELNAC. Moreover, the FFS‐AP1+CF group displays epidermis thickness, number of regenerated hair follicles, and collagen density closer to normal skin tissue. These findings highlight the potential of random fibroin fibers/aligned CFs hybrid fibrous scaffold as a promising approach for skin tissue filling and tissue regeneration.
Tunable Adhesion for All‐Dry Transfer of 2D Materials Enabled by the Freezing of Transfer Medium
Authors: Chen Sensheng , Chen Ge , Zhao Yixuan , Bu Saiyu , Hu Zhaoning , Mao Boyang , Wu Haotian , Liao Junhao , Li Fangfang , Zhou Chaofan , Guo Bingbing , Liu Wenlin , Zhu Yaqi , Lu Qi , Hu Jingyi , Shang Mingpeng , Shi Zhuofeng , Yu Beiming , Zhang Xiaodong , Zhao Zhenxin , Jia Kaicheng , Zhang Yanfeng , Sun Pengzhan , Liu Zhongfan , Lin Li , Wang Xiaomin 
Published: January 2024

AbstractThe real applications of chemical vapor deposition (CVD)‐grown graphene films require the reliable techniques for transferring graphene from growth substrates onto application‐specific substrates. The transfer approaches that avoid the use of organic solvents, etchants, and strong bases are compatible with industrial batch processing, in which graphene transfer should be conducted by dry exfoliation and lamination. However, all‐dry transfer of graphene remains unachievable owing to the difficulty in precisely controlling interfacial adhesion to enable the crack‐ and contamination‐free transfer. Herein, through controllable crosslinking of transfer medium polymer, the adhesion is successfully tuned between the polymer and graphene for all‐dry transfer of graphene wafers. Stronger adhesion enables crack‐free peeling of the graphene from growth substrates, while reduced adhesion facilitates the exfoliation of polymer from graphene surface leaving an ultraclean surface. This work provides an industrially compatible approach for transferring 2D materials, key for their future applications, and offers a route for tuning the interfacial adhesion that would allow for the transfer‐enabled fabrication of van der Waals heterostructures.
Molecular Engineering Enables Hydrogel Electrolyte with Ionic Hopping Migration and Self‐Healability toward Dendrite‐Free Zinc‐Metal Anodes
Authors: Zhu Kaiping , Luo Jie , Zhang Dehe , Wang Nanyang , Pan Shibo , Zhou Shujin , Zhang Zhenjie , Guo Gengde , Yang Peng , Fan Yuan , Hou Shisheng , Shao Zhipeng , Liu Shizhuo , Lin Lin , Xue Pan , Hong Guo , Yang Yurong , Yao Yagang 
Published: January 2024

AbstractHydrogel electrolytes (HEs), characterized by intrinsic safety, mechanical stability, and biocompatibility, can promote the development of flexible aqueous zinc‐ion batteries (FAZIBs). However, current FAZIB technology is severely restricted by the uncontrollable dendrite growth arising from undesirable reactions between the HEs with sluggish ionic conductivity and Zn metal. To overcome this challenge, this work proposes a molecular engineering strategy, which involves the introduction of oxygen‐rich poly(urea‐urethane) (OR‐PUU) into polyacrylamide (PAM)‐based HEs. The OR‐PUU/PAM HEs facilitate rapid ion transfer through their ionic hopping migration mechanism, resulting in uniform and orderly Zn2+ deposition. The abundant polar groups on the OR‐PUU molecules in OR‐PUU/PAM HEs break the inherent H‐bond network, tune the solvation structure of hydrated Zn2+, and inhibit the occurrence of side reactions. Moreover, the interaction of hierarchical H‐bonds in the OR‐PUU/PAM HEs endows them with self‐healability, enabling in situ repair of cracks induced by plating/stripping. Consequently, Zn symmetric cells incorporating the novel OR‐PUU/PAM HEs exhibit a long cycling life of 2000 h. The resulting Zn–MnO2 battery displays a low capacity decay rate of 0.009% over 2000 cycles at 2000 mA g−1. Overall, this work provides valuable insights to facilitate the realization of dendrite‐free Zn‐metal anodes through the molecular engineering of HEs.
Organocatalytic Activation of Pyruvates Toward Michael Addition to Nitroalkenes: Synthesis of γ‐Aminobutyric Acid (GABA) Derivatives
Authors: Włoszczak Łukasz Adam , Karczewski Romuald , Mlynarski Jacek 
Published: January 2024

AbstractDespite the significant role of pyruvic acid in biotransformations, the utilization of pyruvates in the field of catalytic asymmetric synthesis has been unexpectedly limited. This statement also applies to enamine catalysis, in which pyruvates seem to be challenging substrates. Recently, the first illustration of the asymmetric addition of pyruvic acid to β‐nitrostyrenes, catalyzed by a NahE enzyme using the enamine mechanism, has appeared in the literature. Now, we demonstrate pyrrolidine‐based catalyst can mimick enamine mechanism used by this enzyme to activate pyruvates in the asymmetric addition to structurally diverse nitroalkenes to produce highly enantioenriched Michael adducts without the limitations in substrate structures associated with biocatalysts. In addition to confirming that optically pure pyrrolidines can serve as ultimately small organic catalysts in pyruvate activation, we present an exceedingly simple and versatile method for the synthesis of optically pure γ‐nitro acids, which are precursors for well‐known active pharmaceutical ingredients namely GABA derivatives
Defective Homologous Recombination Repair By Up‐Regulating Lnc‐HZ10/Ahr Loop in Human Trophoblast Cells Induced Miscarriage
Authors: Chen Weina , Mi Chenyang , Zhang Ying , Yang Yang , Huang Wenxin , Xu Zhongyan , Zhao Jingsong , Wang Rong , Wang Manli , Wan Shukun , Wang Xiaoqing , Zhang Huidong 
Published: January 2024

AbstractHuman trophoblast cells are crucial for healthy pregnancy. However, whether the defective homologous recombination (HR) repair of dsDNA break (DSB) in trophoblast cells may induce miscarriage is completely unknown. Moreover, the abundance of BRCA1 (a crucial protein for HR repair), its recruitment to DSB foci, and its epigenetic regulatory mechanisms, are also fully unexplored. In this work, it is identified that a novel lnc‐HZ10, which is highly experssed in villous tissues of recurrent miscarriage (RM) vs their healthy control group, suppresses HR repair of DSB in trophoblast cell. Lnc‐HZ10 and AhR (aryl hydrocarbon receptor) form a positive feedback loop. AhR acts as a transcription factor to promote lnc‐HZ10 transcription. Meanwhile, lnc‐HZ10 also increases AhR levels by suppressing its CUL4B‐mediated ubiquitination degradation. Subsequently, AhR suppresses BRCA1 transcription; and lnc‐HZ10 (mainly 1‐447 nt) interacts with γ‐H2AX; and thus, impairs its interactions with BRCA1. BPDE exposure may trigger this loop to suppress HR repair in trophoblast cells, possibly inducing miscarriage. Knockdown of murine Ahr efficiently recovers HR repair in placental tissues and alleviates miscarriage in a mouse miscarriage model. Therefore, it is suggested that AhR/lnc‐HZ10/BRCA1 axis may be a promising target for alleviation of unexplained miscarriage.
Review of computer‐aided methods in fat crystallization studies
Authors: Qi Ang , Zhang Lu 
Published: January 2024

AbstractWith recent improvements in computer performance, computer‐aided studies have become increasingly important. Computer‐aided methods have been applied in fat crystallization studies for modeling, simulation, optimization, data analysis and visualization. In this paper, various methods, such as molecular dynamic simulation, Monte Carlo, cellular automata modeling, finite element analysis, machine learning and computer vision, are introduced. Applications and advances in mechanism explanation, behavior prediction, process optimization, and so forth, are reviewed for fat crystallization. As a powerful and essential tool, computer‐aided study should play an important role in the field of lipid research in the future.
Antioxidative effects of alkyl esters of sinapic acid on flaxseed oil and its fatty acid methyl esters
Authors: Arslan Derya , Polak Tomaž , Poklar Ulrih Nataša 
Published: January 2024

AbstractAlkyl esters of sinapic acid were enzymatically synthesized by using hexanol CH3(CH2)5OH and palmitoyl chloride CH3(CH2)14COCl as acyl donors. The lipid oxidation retarding activities of these conjugates were determined using different methods in two lipid media; bulk flaxseed oil and its fatty acid methyl esters (FAME). Palmitoyl sinapate more efficiently slowed down the formation of primary and secondary oxidation products in both lipid media. In terms of DPPH radical scavenging activity, β‐carotene bleaching and TEAC assays, it provided higher activity compared to hexyl ester in FAME. Hexyl ester was more active in bulk oil in terms of antioxidant activity analyses. The alkyl side chain length of these molecules had an impact on their antioxidative activity and this effect differed according to the environment in which they were used. The conjugates remained more stable on storage compared to the phenolic compounds originally found in the oil samples.
ESG ratings and green innovation: A U‐shaped journey towards sustainable development
Authors: Yang Cunyi , Zhu Conghao , Albitar Khaldoon 
Published: January 2024

AbstractThis study examines the relationship between corporate ESG ratings and green innovation based on data from Chinese A‐share listed companies for the period between 2011 and 2022. The findings suggest a “U”‐ shaped relationship between ESG ratings and green innovation. Companies with lower ESG ratings (referred to as “bad” companies) tend to focus on improving their corporate governance and operational conditions, often at the expense of green innovation. However, as companies improve their ESG ratings, they increasingly view green innovation as a key growth area. This relationship is particularly evident in companies with low profitability and high operational risks. Additionally, we explore the impact of corporate ESG ratings on different types of green patents. The study finds that “bad” companies can mitigate the negative impact on green innovation through collaborative efforts, while non‐inventive green innovations, they benefit from independent research and development. Furthermore, the study examines the role of government subsidies and executive compensation in influencing this relationship. The results show that government subsidies can both positively and negatively affect green innovation, depending on the company's operational status and ESG rating. The results provide valuable insights for companies, investors, and policymakers regarding the significant role of ESG scores in promoting green innovation and suggest strategies to enhance corporate sustainability performance.
Endothelial‐mesenchymal transition in skeletal muscle: Opportunities and challenges from 3D microphysiological systems
Authors: Francescato Riccardo , Moretti Matteo , Bersini Simone 
Published: January 2024

AbstractFibrosis is a pathological condition that in the muscular context is linked to primary diseases such as dystrophies, laminopathies, neuromuscular disorders, and volumetric muscle loss following traumas, accidents, and surgeries. Although some basic mechanisms regarding the role of myofibroblasts in the progression of muscle fibrosis have been discovered, our knowledge of the complex cell–cell, and cell–matrix interactions occurring in the fibrotic microenvironment is still rudimentary. Recently, vascular dysfunction has been emerging as a key hallmark of fibrosis through a process called endothelial‐mesenchymal transition (EndoMT). Nevertheless, no effective therapeutic options are currently available for the treatment of muscle fibrosis. This lack is partially due to the absence of advanced in vitro models that can recapitulate the 3D architecture and functionality of a vascularized muscle microenvironment in a human context. These models could be employed for the identification of novel targets and for the screening of potential drugs blocking the progression of the disease. In this review, we explore the potential of 3D human muscle models in studying the role of endothelial cells and EndoMT in muscle fibrotic tissues and identify limitations and opportunities for optimizing the next generation of these microphysiological systems. Starting from the biology of muscle fibrosis and EndoMT, we highlight the synergistic links between different cell populations of the fibrotic microenvironment and how to recapitulate them through microphysiological systems.
Chymotrypsin and Trypsin Inhibitory Activity of Some Medicinal Plants Collected from Rize (Türkiye)
Authors: Gunbatan Tugba , Sucu Melike , Gokbulut Alper , Dilmac Elif , Gurbuz Ilhan 
Published: January 2024

AbstractIn this research, the evaluation of in vitro chymotrypsin and trypsin inhibitory activities of ten plant species collected from Rize were aimed, and fractions that showed strong activity were analyzed through HPLC. Daphne pontica L. and Mentha longifolia (L.) L. were found to have the highest chymotrypsin inhibitory activities (87.75 and 84.24 % inhibition). Similarly, the highest trypsin inhibitory activity was observed in D. pontica (%99.93 inhibition), followed by Sambucus ebulus L. flowers (87.47 % inhibition). Extracts showing strong enzyme inhibition were fractioned and subjected to activity tests. The highest chymotrypsin inhibitory activity was observed in the n‐hexane fraction of D. pontica (%80.70 inhibition), while the highest trypsin inhibitory activity was found in the n‐butanol fraction of S. ebulus (%86.81 inhibition). HPLC studies determined that the 80 % ethanol extract of D. pontica and its dichloromethane and ethyl acetate fractions contained umbelliferone. It was found that chlorogenic acid was present in the 80 % ethanol extracts of S. ebulus flowers. M. longifolia was found to contain chlorogenic acid, caffeic acid, luteolin‐7‐glucoside, and rosmarinic acid. M. longifolia has been identified as the plant exhibiting the highest antioxidant activity in ABTS and CUPRAC tests, consistent with its high phenolic and flavonoid content.
Photo‐affinity and Metabolic Labeling Probes Based on the Opioid Alkaloids
Authors: Duque Mark Anthony Leon , Vallavoju Nandini , Zhang Tiffany , Yvon Robert , Pan Ying‐Xian , Woo Christina M. 
Published: January 2024

AbstractThe opioids are powerful analgesics yet possess contingencies that can lead to opioid‐use disorder. Chemical probes derived from the opioid alkaloids can provide deeper insight into the molecular interactions in a cellular context. Here, we designed and developed photo‐click morphine (PCM‐2) as a photo‐affinity probe based on morphine and dialkynyl‐acetyl morphine (DAAM) as a metabolic acetate reporter based on heroin. Application of these probes to SH‐SY5Y, HEK293T, and U2OS cells revealed that PCM‐2 and DAAM primarily localize to the lysosome amongst other locations inside the cell by confocal microscopy and chemical proteomics. Interaction site identification by mass spectrometry revealed the mitochondrial phosphate carrier protein, solute carrier family 25 member 3, SLC25A3, and histone H2B as acylation targets of DAAM. These data illustrate the utility of chemical probes to measure localization and protein interactions in a cellular context and will inform the design of probes based on the opioids in the future.
A challenging transseptal mitral valve in valve case report: Success and safety
Authors: Alizadehasl Azin , Eslami Samira , Vakili Kimia , Abdi Seifollah , Firouzi Ata , Azarfarin Rasoul , Abdi Amir 
Published: January 2024

Key Clinical MessageTranscatheter mitral valve implantation (TMVI) is considered a less‐invasive approach than open‐heart surgery, favored in high‐risk patients elected for valve replacement. Although seemingly suitable, this procedure is highly operator‐dependent.AbstractTranscatheter mitral valve implantation (TMVI) is an alternative in high‐risk patients. We reported a 72‐year‐old patient with mitral bioprosthesis degeneration successfully receiving TMVI. The procedure has lower morbidity and mortality rate than the surgical approach but can be accompanied by several complications, especially when conducted by an inexperienced operator.
Prospects for green steelmaking technology with low carbon emissions in China
Authors: Fucheng Zhang , Lukuo Hong , Ying Xu 
Published: January 2024

AbstractThe steel industry is a major source of CO2 emissions, and thus, the mitigation of carbon emissions is the most pressing challenge in this sector. In this paper, international environmental governance in the steel industry is reviewed, and the current state of development of low‐carbon technologies is discussed. Additionally, low‐carbon pathways for the steel industry at the current time are proposed, emphasizing prevention and treatment strategies. Furthermore, the prospects of low‐carbon technologies are explored from the perspective of transitioning the energy structure to a “carbon–electricity–hydrogen” relationship. Overall, steel enterprises should adopt hydrogen‐rich metallurgical technologies that are compatible with current needs and process flows in the short term, based on the carbon substitution with hydrogen (prevention) and the CCU (CO2 capture and utilization) concepts (treatment). Additionally, the capture and utilization of CO2 for steelmaking, which can assist in achieving short‐term emission reduction targets but is not a long‐term solution, is discussed. In conclusion, in the long term, the carbon metallurgical process should be gradually supplanted by a hydrogen–electric synergistic approach, thus transforming the energy structure of existing steelmaking processes and attaining near‐zero carbon emission steelmaking technology.
Grundlagenuntersuchungen zum Einfluss verschiedener Zerkleinerungsparameter auf die spezifische Zerkleinerungsarbeit von kohlenstofffaserverstärkten Kunststoffen
Authors: Niebel Philipp Karsten , Krampitz Thomas , Lieberwirth Holger , Zeisberg Marcel 
Published: January 2024

AbstractBei kohlenstofffaserverstärktem Kunststoff (CFK) handelt es sich um einen zunehmend eingesetzten Leichtbauwerkstoff mit begrenzter Recyclingfähigkeit. Da die Zerkleinerung von Abfällen einen unvermeidbaren Schritt jeder Recyclingprozesskette für CFK darstellt, werden in diesem Artikel konstruktive, betriebsbedingte und stoffliche Einflussgrößen des Zerkleinerungsprozesses untersucht. Dafür werden an einem Pendelschlagwerk die Beanspruchungsarbeit, die Reibungsverluste sowie die auftretenden Kräfte ermittelt. Die Materialeigenschaften und die Beanspruchungsart haben einen signifikanten Effekt auf das Zerkleinerungsverhalten von CFK. Aus den Ergebnissen können materialspezifisch konstruktive Maßnahmen zur Reduktion der zur Zerkleinerung benötigten Energie abgeleitet werden.