bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome
Authors: Venkatraman Kailash , Lee Christopher T , Garcia Guadalupe C , Mahapatra Arijit , Milshteyn Daniel , Perkins Guy , Kim Keun‐Young , Pasolli H Amalia , Phan Sebastien , Lippincott‐Schwartz Jennifer , Ellisman Mark H , Rangamani Padmini , Budin Itay 
Published: November 2023

AbstractCristae are high‐curvature structures in the inner mitochondrial membrane (IMM) that are crucial for ATP production. While cristae‐shaping proteins have been defined, analogous lipid‐based mechanisms have yet to be elucidated. Here, we combine experimental lipidome dissection with multi‐scale modeling to investigate how lipid interactions dictate IMM morphology and ATP generation. When modulating phospholipid (PL) saturation in engineered yeast strains, we observed a surprisingly abrupt breakpoint in IMM topology driven by a continuous loss of ATP synthase organization at cristae ridges. We found that cardiolipin (CL) specifically buffers the inner mitochondrial membrane against curvature loss, an effect that is independent of ATP synthase dimerization. To explain this interaction, we developed a continuum model for cristae tubule formation that integrates both lipid and protein‐mediated curvatures. This model highlighted a snapthrough instability, which drives IMM collapse upon small changes in membrane properties. We also showed that cardiolipin is essential in low‐oxygen conditions that promote PL saturation. These results demonstrate that the mechanical function of cardiolipin is dependent on the surrounding lipid and protein components of the IMM.
Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions
Authors: Ko Chih-Hung , Király Orsolya , Demetrovics Zsolt , Griffiths Mark D. , Kato Takahiro A. , Tateno Masaru , Yen Ju-Yu 
Published: November 2023

AbstractBackgroundThe eleventh revision of the International Classification of Diseases (ICD-11) defines the three key diagnostic criteria for gaming disorder (GD). These are loss of control over gaming, gaming as a priority over daily activities, and impaired functioning due to gaming. While this definition has implications for the prevention and treatment of GD, there is significant heterogeneity in the symptoms and etiology of GD among individuals, which results in different treatment needs. Cognitive control, emotional regulation, and reward sensitivity are three critical dimensions in the etiology model for GD. Aspects such as gender, comorbidity, motivation for gaming, stage or severity of GD, and risk factors all contribute to the heterogeneity of etiology among individuals with the disorder.MethodOn the basis of clinical symptoms and comorbidity characteristics among approximately 400 patients with gaming disorder, the present paper proposes a clinical typology of patients with GD based on the authors' clinical experience in treating individuals with GD.ResultsThe findings indicated three common types of patients with GD: (i) impulsive male patients with attention deficit hyperactivity disorder (ADHD), (ii) dysphoria patients with dysfunctional coping skills, and (iii) isolated patients with social anxiety. The paper also discusses the presentation and treatment priority for these patients.ConclusionPersonalized treatments for patients with GD should be developed to fit their individual needs. Future studies should examine the heterogeneity of GD and confirm these types, as well as obtain evidence-based information that can help in the development of personalized treatment. Treatment resources should be developed, and professionals should be trained to provide integrated individualized treatment.
Chorus angelorum. Uno sguardo allapartecipazione attiva dell’assemblealiturgica e alla funzionalità del coro
Authors: Marinčák Šimon 
Published: November 2023

The issue of the active participation of the liturgical assembly in worship is a question to which it is difficult to find a satisfactory answer. The choir plays a key role in this problem. While some see its performance as enriching and enhancing the solemnity of the service, others see it as a hindrance or even a limitation to the active participation of the people. Certain indications are offered by the documents of the Second Vatican Council, but these cannot be applied unreservedly to another tradition, in the case of Slovakia and the Byzantine tradition. This study thus attempts to gain insight into this issue, offering some facts that speak mainly in favor of the participation of the choir, but at the same time confirming that the activity of the choir does not prevent the full and active participation of the people in the liturgy.
Clinically significant CYP2C19 genotypes in patients with myocardial infarction in the northern region of Russia
Authors: Vorobyov A. S. , Lifshits G. I. , Zelenskaya E. M. , Batueva K. Yu. , Kovalenko L. V. , Urvantseva I. A. , Donnikov M. Yu. , Morozkina A. V. , Nikolaev K. Yu. 
Published: November 2023

Aim. To determine the associations of allelic variants of the CYP2C19 gene with coronary atherosclerosis and ischemic events in patients with myocardial infarction (MI) living in the Khanty-Mansi Autonomous Okrug — Yugra.Material and methods. This prospective observational study included 203 patients with acute MI who underwent percutaneous coronary intervention. Patients also underwent genetic testing using real-time polymerase chain reaction to determine allelic variants of the CYP2C19 gene. Using biostatistical analysis methods, associations were established between the genotypes of patients with MI, their clinical characteristics and major ischemic events over 7-year follow-up.Results. Significant associations were identified between allelic variants of CYP2C19*2 (*1/*2 and *2/*2) and smoking, right ventricular volume and glomerular filtration rate (GFR). The presence of the allelic variant CYP2C19*3 (*3/*3) was associated with GFR ³90 ml/min/1,73 m2 and impaired glucose tolerance. A significant association was established between the CYP2C19*17 alleles (*1/*17, *17/*17) with coronary atherosclerosis, smoking, levels of troponin T, aspartate aminotransferase, total cholesterol, left ventricular posterior wall thickness, and a history of myocardial infarction. Data from multivariate analysis showed a clear association of allelic variants of CYP2C19*2 (*1/*2 and *2/*2) with the composite endpoint of 7-year follow-up (death, recurrent myocardial infarction, stent/bypass thrombosis, myocardial revascularization). A significant influence of CYP2C19*17 genotypes (*1/*17 and *17/*17) on myocardial revascularization in patients in the post-infarction period was also determined.Conclusion. CYP2C19*2 genotypes (*1/*2 and *2/*2) in MI patients living in Khanty-Mansi Autonomous Okrug — Yugra are clearly associated with ischemic events during a 7-year follow-up. CYP2C19*17 genotypes (*1/*17 and *17/*17) are clearly associated with coronary atherosclerosis and myocardial revascularization in the long-term post-infarction period.
Diversified Nature of the Principle of Good Faith in Russian Law
Authors: Bogdanova E. E. 
Published: November 2023

In the article, the author examines the processes of changing legislation in Russia that reflect the general trends formed in society. The author concludes that by analyzing the trends in the development of domestic and foreign law, it is possible to predict the main directions of the development of legislation, including specific nature of the application of the principle of good faith.The paper notes that one of the trends that have developed in foreign legal systems is the constitutionalization of private law and the strengthening of the principles of socialization of law, expressed in the evolution of the principle of good faith. Dissemination of the principle of good faith in public legal relations forms another direction in law that, according to the author, means dissemination of the principle of good faith in public legal relations, which is why this principle is applied, in particular, in tax relations.As a result of the study, the author comes to the conclusion that in order to ensure uniformity of the constitutional law approach to the application of the principle of good faith, given that constitutional norms, principles and values should act as direct regulators of public relations within the process of socialization of law that is carried out simultaneously with the gradual blurring of the dividing line between private and public law, it is advisable to distribute civil law approaches to applying the principle of good faith as the most effective and developed, to other branches of law, which will correspond to the diversified nature of this principle.
Bringing Medical Workers to Disciplinary Responsibility: Current Problems in context of Introduction of Digital Technologies in Medical Activities
Authors: Shonia G. V. 
Published: November 2023

Digital technologies have become an integral part of modern life. Digital medical services is one of the forms of activity of almost any medical organization. For this reason, the problems of implementation of the work function of medical personnel are relevant. When a medical worker is performing a medical intervention using digital medical technologies, other criteria for evaluating the proper performance of their work function should be taken into account. The specifics of these criteria have an impact on the establishment of grounds for bringing a medical professional to disciplinary responsibility. The work of medical workers is of special social significance. Nowadays, almost no medical intervention is performed without the use of artificial intelligence, artificial intelligence technologies, robots, applications, bots, etc. They became widespread during the introduction of remote labor formats and lock downs, when various software tools were used for remote provision of medical services.The labor legislation establishes general grounds for bringing medical workers to disciplinary responsibility, as well as traditional disciplinary measures. We believe that bringing medical workers to disciplinary responsibility has a strongly pronounced specificity. This is especially evident in the context of introduction of digital technologies in medical activities.Based on the analysis of modern legislation and law enforcement practice, we have identified special grounds for bringing medical workers to disciplinary responsibility, analyzed typical cases of labor discipline violations by medical workers, and developed recommendations on the tactics of conducting a disciplinary internal investigation by an employer (medical organization). The author provides recommendations for fixing certain conditions in the explanatory note of a medical worker.
Exonerative and Non-Exonerative Grounds for Administrative Offense Case Dismissal
Authors: Morozova N. A. 
Published: November 2023

In the paper, the author proposes to divide all the circumstances entailing the termination of proceedings in a case of an administrative offense into three groups. The first unites grounds that should be regarded as irremediable procedural obstacles and in the presence of which this particular proceeding is impossible due to procedural obstacles, but at the same time, the issue of the offender’s responsibility can be resolved in another case. In the second group, the author proposes to include grounds resulting in impossibility of holding a person liable due to the lack of cause. The dismissal of the proceedings under these circumstances makes reopening of the case impossible; at the same time the innocence of the person is considered established. The third group includes grounds in the presence of which the offender, whose guilt is established, is released from the obligation to undergo punishment, while the conclusion about the illegality of his actions remains valid.The author believes that the lack of legislative regulation of this issue generates legal disputes and may negatively affect the effectiveness of the protection of the rights of persons against whom a case on administrative liability has been unreasonably initiated.
State Development Institutions in the System of Innovation Cooperation: Asian Countries Experience
Authors: Kravets V. D. 
Published: November 2023

In modern conditions, the main direction of the technological policy of the Russian Federation is to ensure technological sovereignty. The creation of critical and end-to-end technologies of proper development and production of goods, works and services based thereon is possible only in the conditions of integration and cooperation of research and production and technical activities. The functioning of the innovation cooperation system is impossible without the direct participation of state development institutions that perform an organizing role, ensure the creation and development of infrastructure.The paper analyzes the activities of state development institutions in Asian countries (the People’s Republic of China, Japan, the Republic of India, the Republic of Kazakhstan and the Republic of Singapore), their functions, including ensuring the commercialization of scientific research and technology transfer. The experience of building a system of innovation cooperation of these countries is of direct interest, firstly, due to the existence of developed economic relations between the Russian Federation and a number of analyzed countries, and secondly, because it was the Asian countries that managed to make a technological breakthrough in a fairly short time.The analysis showed that state development institutions in the analyzed countries are created as state-owned companies subordinate to government structures and perform functions for the implementation of state strategies for scientific and technological development. The activities of the institutions under consideration depend on the level of economic development and the chosen type (nature) of technological modernization. State development institutions are holdings, while there is a tendency to merge and consolidate them. However, the reforms carried out by states do not always have positive results.
Evaluation of Station Performance of the Indonesian Seismic Network Using the Primary Location Parameter
Authors: Puspito Nanang T. , Prayitno Bambang S. , Nugraha Andri D. , Sahara David P. , Kusumawati Dian , Zulfakriza Zulfakriza , Rosalia Shindy , Daryono Daryono , Heryandoko Nova , Sudrajat Ajat , Supendi Pepen , Adi Suko P. , Karnawati Dwikorita 
Published: November 2023

Abstract
Indonesia’s tectonic setting has resulted in a high level of seismic activity, which makes seismic networks and early warning systems vital for this country. Indonesia’s seismic stations, a total of 411 stations in 2021, are maintained by the Meteorological, Climatological, and Geophysical Agency (BMKG). This study attempts to evaluate station performance, because these are crucial in monitoring seismic activity. We utilized information from the BMKG 2020 and 2019 seismic catalogs to analyze the performance of the stations. A total of 13,798 events were reported in 2019 with magnitudes (MLv) of up to 8, whereas 10,163 events with similar magnitudes were reported in 2020. Stations in the eastern part of Indonesia (Sulawesi, Lesser Sunda Islands, the Moluccas, and Papua) detected more events compared to stations in the western part of Indonesia (Borneo, Sumatra, and Java). Up to 1651 events were detected by a single station in eastern Indonesia, compared to 847 events in western Indonesia. BMKG stations in eastern Indonesia have recorded ample amounts of events, which is consistent with the high seismic activity found there. In terms of station coverage, events in the eastern part have better station coverage due to smaller azimuthal gaps, considering the geographic location. We also analyzed station performance and the number of recorded stations in terms of a function of time for each event in the Sumatra, Sulawesi, Lesser Sunda Islands, and Papua regions. Although the number of recordings obtained by stations was high after 15 s since the origin time, the azimuthal gap progression in Sumatra and Java remained large. Therefore, an additional ocean-bottom seismometer needs to be installed in the Sumatra–Java trench.
Fine-Tuning IndoBERT for Indonesian Exam Question Classification Based on Bloom's Taxonomy
Authors: Baharuddin Fikri , Naufal Mohammad Farid 
Published: November 2023

Background: The learning assessment of elementary schools has recently incorporated Bloom's Taxonomy, a structure in education that categorizes different levels of cognitive learning and thinking skills, as a fundamental framework. This assessment now includes High Order Thinking Skill (HOTS) questions, with a specific focus on Indonesian topics. The implementation of this system has been observed to require teachers to manually categorize or classify questions, and this process typically requires more time and resources. To address the associated difficulty, automated categorization and classification are required to streamline the process. However, despite various research efforts in questions classification, there is still room for improvement in terms of performance, particularly in precision and accuracy. Numerous investigations have explored the use of Deep Learning Natural Language Processing models such as BERT for classification, and IndoBERT is one such pre-trained model for text analysis.
Objective: This research aims to build classification system that is capable of classifying Indonesian exam questions in multiple-choice form based on Bloom's Taxonomy using IndoBERT pre-trained model.
Methods: The methodology used includes hyperparameter fine-tuning, which was carried out to identify the optimal model performance. This performance was subsequently evaluated based on accuracy, F1 Score, Precision, Recall, and the time required for the training and validation of the model.
Results: The proposed Fine Tuned IndoBERT Model showed that the accuracy rate was 97%, 97% F1 Score, 97% Recall, and 98% Precision with an average training time per epoch of 1.55 seconds and an average validation time per epoch of 0.38 seconds.
Conclusion: Fine Tuned IndoBERT model was observed to have a relatively high classification performance, and based on this observation, the system was considered capable of classifying Indonesian exam questions at the elementary school level.
Keywords: IndoBERT, Fine Tuning, Indonesian Exam Question, Model Classifier, Natural Language Processing, Bloom’s Taxonomy
Effectiveness of Thromboprophylaxis Agents Following Hip Fracture
Authors: Negm Ahmed M. , Yamaura Lisa , Clarke Ashley , Chaudhry Daniyya , Cherppukaran Tanya , Schneider Prism 
Published: November 2023

Background:
Multiple studies have compared different pharmacologic thromboprophylaxis agents after hip fracture surgery, including aspirin, unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), direct oral anticoagulants (DOAC), and warfarin, resulting in variability in clinical practice. To guide clinical management, a systematic review and network meta-analysis (NMA), which enables the simultaneous assessment of the effects of multiple interventions for the same patient population, was performed. This study aimed to determine the comparative effectiveness of thromboprophylaxis in reducing venous thromboembolism (VTE) in patients with surgically treated hip fractures.

Methods:
The primary outcome was the effect of the treatment on the VTE rate, and the secondary outcome was the treatment effect on the bleeding rate. Relevant studies were identified by a systematic search of Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from January 2000 to February 2022. Title, abstract, and full-text screening; data extraction; and risk-of-bias assessment were performed. All studies examining thromboprophylaxis interventions (DOAC, LMWH, UFH, aspirin, and warfarin) in patients with a surgically treated hip fracture were included. Bayesian NMA was performed, and dichotomous outcome data were pooled using the odds ratio. Interventions were ranked using the surface under the cumulative ranking curve (SUCRA) for each outcome.

Results:
A total of 19 studies were included after the screening of 466 citations and 77 full-text articles. Of the included studies, 15 studies had a high overall risk of bias. The NMA of the VTE outcome included 19 studies, 49,409 participants, and 6 thromboprophylaxis interventions. The NMA of the bleeding outcome included 3 studies, 18,163 participants, and 3 interventions. The mean age ranged from 43.5 to 86.2 years among the included studies. No thromboprophylaxis intervention was statistically different from any other intervention in its effect on the VTE or bleeding rate in hip fracture patients.

Conclusions:
This NMA demonstrated that there was no difference between the thromboprophylaxis interventions in reducing VTE or bleeding rates in hip fracture patients. More robust randomized controlled trials are needed to determine the most effective thromboprophylaxis interventions for patients with hip fractures.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Optimal Adaptive Sliding Mode Controller Design for a Wavelet-based Approximated Nonlinear System
Authors: PATHAK RAJEEV RANJAN , Paul Rimi , Sengupta Anindita 
Published: November 2023

Abstract
This work presents an optimization-based robust Adaptive Gain Sliding Mode (AGSM) controller for a nonlinear system where wavelet-based approximation technique is employed in contrary to the linearization technique. To find out the mother wavelet corresponding to the best approximation of nonlinear model, Minimum Description Length (MDL) criterion is utilized. Three different wavelet series are considered to find the best mother wavelet function. The constant of the sliding surface follows dynamical adaptive nature using Harmony Search Algorithm (HSA) based optimization technique to mitigate the extent of chattering. On the other hand, the gain adaptation method is used to calculate the gain of the switching control law of Sliding Mode Control. To ensure the stability of the closed-loop system with adapted gain as well as optimal sliding constants, Lyapunov Stability Criterion is exploited. To validate the performance of the proposed controller (Optimal AGSM Controller) in real time, an Inverted Pendulum System is taken with its wavelet approximated model. The results obtained from simulation as well as hardware validate the efficacy of the proposed design with the assurance of handling unbounded disturbances, parametric uncertainties, and chattering.