bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumption of ultra-processed foods and risk for Alzheimer’s disease: a systematic review
Authors: Claudino Paola Alves , Bueno Nassib Bezerra , Piloneto Sabrina , Halaiko Dieniffer , Azevedo de Sousa Leticia Priscila , Barroso Jara Maia Cassia Helena , Netto Bárbara Dal Molin 
Published: January 2024

ObjectiveTo investigate the association of the consumption of ultra-processed foods with the risk of developing Alzheimer’s disease in adults and the elderly. The review protocol was registered on PROSPERO (CRD42022375944).MethodsThis is a systematic review reported according to PRISMA guidelines. Observational studies were included without language or publication year restrictions. Studies assessing only other types of dementia as outcomes, not considering Alzheimer’s disease, were excluded. The research was carried out in the Medline, Embase, Lilacs databases, and a survey of the gray literature between April and November 2023, in addition to citation search in the included studies. Data extraction was performed by two independent reviewers. The risk of bias and methodological quality of the included studies were assessed using the Joanna Briggs Institute checklist for cohort studies.ResultsA total of 5 studies involving 617,502 adults and elderly people were included. All studies had a cohort design and were considered of high methodological quality. Of the included studies, 4 demonstrated a risk association between the consumption of ultra-processed foods and the development of Alzheimer’s disease, while 1 study showed a risk association only with the development of cognitive decline.DiscussionThe association between ultra-processed foods consumption and the risk of developing Alzheimer’s disease is a recent topic in scientific studies, given that the oldest study identified by our review dates back to 2017. Of the four included studies, three showed a significant association between ultra-processed foods consumption and the risk of developing Alzheimer’s disease.
Clear cell renal cell carcinoma: immunological significance of alternative splicing signatures
Authors: Zhang Jiayu , Jiang Hongyi , Rao Dapang , Jin Xishi 
Published: January 2024

BackgroundRenal cell carcinoma (RCC) accounts for 90% of renal cancers, of which clear cell carcinoma (ccRCC) is the most usual histological type. The process of alternative splicing (AS) contributes to protein diversity, and the dysregulation of protein diversity may have a great influence on tumorigenesis. We developed a prognostic signature and comprehensively analyzed the role of tumor immune microenvironment (TIME) and immune checkpoint blocking (ICB) treatment in ccRCC.MethodsTo identify prognosis-related AS events, univariate Cox regression was used and functional annotation was performed using gene set enrichment analysis (GSEA). In this study, prognostic signatures were developed based on multivariate Cox, univariate Cox, and LASSO regression models. Moreover, to assess the prognostic value, the proportional hazards model, Kruskal–Wallis analysis, and ROC curves were used. To obtain a better understanding of TIME in ccRCC, the ESTIMATE R package, single sample gene set enrichment analysis (ssGSEA) algorithm, CIBERSORT method, and the tumor immune estimation resource (TIMER) were applied. The database was searched to verify the expression of C4OF19 in tumor and normal samples. Regulatory networks for AS-splicing factors (SFs) were visualized using Cytoscape 3.9.1.ResultsThere were 9,347 AS cases associated with the survival of ccRCC patients screened. A total of eight AS prognostic signatures were developed with stable prognostic predictive accuracy based on splicing subtypes. In addition, a qualitative prognostic nomogram was developed, and the prognostic prediction showed high effectiveness. In addition, we found that the combined signature was significantly associated with the diversity of TIME and ICB treatment-related genes. C4ORF19 might become an important prognostic factor for ccRCC. Finally, the AS-SF regulatory network was established to clearly reveal the potential function of SFs.ConclusionWe found novel and robust indicators (i.e., risk signature, prognostic nomogram, etc.) for the prognostic prediction of ccRCC. A new and reliable prognostic nomogram was established to quantitatively predict the clinical outcome. The AS-SF networks could provide a new way for the study of potential regulatory mechanisms, and the important roles of AS events in the context of TIME and immunotherapy efficiency were exhibited. C4ORF19 was found to be a vital gene in TIME and ICB treatment.
Summary of the evidence of best practices for the prevention and treatment of embolism syndrome after TACE in primary liver cancer
Authors: Yao Yanrong , Huang Xi , Zhao Chengsi , Wang XiaoYan , Mi Guangli , Liu Jingli 
Published: January 2024

ObjectiveThis study aims to retrieve, evaluate, and summarize domestic and foreign evidence on the prevention and treatment of embolism syndrome following transcatheter arterial chemoembolization (TACE) for primary liver cancer and to provide an evidence-based foundation for clinical practice.MethodsUtilizing the “6S” model, we conducted a systematic search of UpToDate, BMJ Best Practice, domestic and foreign guidelines, and related databases on the prevention and treatment of embolism syndrome following TACE for primary liver cancer. This search included clinical decision-making, guidelines, systematic reviews, evidence summaries, randomized controlled trials, and expert consensus. The search time frame extended from January 1, 2013 to May 1, 2023. Evidence was synthesized after an independent review of the included studies by two investigators.ResultsA total of 11 articles were included in the analysis, comprising one clinical decision-making article, three clinical guidelines, six expert consensus articles, and one randomized controlled trial. We summarized 31 pieces of evidence across three categories: preoperative preparation, intraoperative interventions, and postoperative symptom management.ConclusionThis study presents a comprehensive summary of the best available evidence on the prevention and treatment of embolism syndrome following TACE for primary liver cancer. These findings can serve as a valuable reference for clinical practitioners, enabling nurses to deliver individualized care based on the symptoms and specific needs of liver cancer patients.Systematic review registrationhttp://ebn.nursing.fudan.edu.cn, identifier ES20232398.
Robotic assisted minimally invasive esophagectomy versus minimally invasive esophagectomy
Authors: Xue Mengchao , Liu Junjie , Lu Ming , Zhang Huiying , Liu Wen , Tian Hui 
Published: January 2024

BackgroundEsophagectomy is the gold standard treatment for resectable esophageal cancer; however, there is insufficient evidence to indicate potential advantages over standard minimally invasive esophagectomy (MIE) in treating thoracic esophageal cancer. Robot-assisted minimally invasive esophagectomy (RAMIE) bridges the gap between open and minimally invasive surgery. In this single-center retrospective review, we compare the clinical outcomes of EC patients treated with MIE and RAMIE.MethodWe retrospectively reviewed the clinical data of patients with esophageal cancer who underwent surgery at Qilu Hospital between August 2020 and August 2022, including 159 patients who underwent MIE and 35 patients who received RAMIE. The intraoperative, postoperative, and preoperative patient characteristics in both groups were evaluated.ResultsExcept for height, the MIE and RAMIE groups showed no significant differences in preoperative features (P&gt;0.05). Further, there were no significant differences in intraoperative indices, including TNM stage of the resected tumor, tumor tissue type, or ASA score, between the two groups. However, statistically significant differences were found in some factors; the RAMIE group had a shorter operative time, less intraoperative bleeding, and more lymph nodes removed compared to the MIE group. Patients in the RAMIE group reported less discomfort and greater chest drainage on the first postoperative day than patients in the MIE group; however, there were no differences in other features between the two datasets.ConclusionBy comparing the clinical characteristics and outcomes of RAMIE with MIE, this study verified the feasibility and safety of RAMIE for esophageal cancer. Overall, RAMIE resulted in more complete lymph node clearance, shorter operating time, reduced surgical hemorrhage, reduced postoperative discomfort, and chest drainage alleviation in patients. To investigate the function of RAMIE in esophageal cancer, we propose undertaking a future clinical trial with long-term follow-up to analyze tumor clearance, recurrence, and survival after RAMIE.
Prognostic significance of Wilms’ tumor gene 1 expression in children with B-cell precursor acute lymphoblastic leukemia
Authors: Xue Yu-juan , Wang Yu , Zhang Le-ping , Lu Ai-dong , Jia Yue-ping , Zuo Ying-xi , Zeng Hui-min 
Published: January 2024

IntroductionThe prognostic role of Wilms’ tumor 1 (WT1) gene expression at diagnosis in children with B cell precursor acute lymphoblastic leukemia (BCP-ALL) is still controversial.MethodsWe detected the WT1 transcript levels of 533 de novo pediatric BCP-ALL patients using TaqMan-based real-time quantitative PCR and analyzed their clinical features.ResultsThe WT1 transcript levels differed among the distinct molecularly defined groups, with the highest levels in the KMT2A rearrangements (KMT2A-r) group. According to the results of the X-tile software, all patients were divided into two groups: WT1/ABL ≥ 0.24% (group A) and &lt;0.24% (group B). The proportions of patients whose age was ≥10 years old, with immunophenotype of Pro-B, belonging in high-risk group, or with minimal residual disease (MRD) ≥ 0.01% at week 12 were significantly higher in group A than in group B. In the B-other group, WT1 overexpression was an independent risk factor of overall survival (OS) rate (P = 0.042), and higher MRD ≥ 0.01% at week 12 was associated with lower OS rate (P&lt;0.001) and event-free survival rate (P&lt;0.001). Moreover, the subgroup analysis revealed that, in patients with initial WBC&lt;50 × 109/L or MRD&lt;0.1% at day 33 or MRD&lt;0.01% at week 12 or in the standard-risk group, WT1 overexpression led to a poorer outcome in comparison with those with WT1 downexpression (P&lt;0.05).DiscussionTherefore, pediatric BCP-ALL with WT1 overexpression had unique clinico-pathological characteristics and poor treatment response. In B-other patients, WT1 overexpression at diagnosis predicted an inferior prognosis. The WT1 gene may serve as a biomarker for monitoring residual disease in the B-other population, especially in children in the standard-risk group.
Successful inguinal interstitial brachytherapy in metastatic cervical carcinoma: a case report
Authors: Qin Yi , Guan Ping , Li Dan , He Huailin , He Wenfeng , Tan Longjing , Deng Xiangyu , Liao Bizhen , Wen Qinglian , Zhang Zhenhua 
Published: January 2024

BackgroundTreatment of metastatic cervical cancer is a tricky issue. Currently, the National Comprehensive Cancer Network (NCCN) guideline recommends chemotherapy combined with bevacizumab for recurrent or metastatic cervical cancer. Still, the recurrence rate is high and the survival rate is low after standard treatment. We urgently need to achieve a multimodal therapy approach for recurrent or metastatic cervical cancer.Case descriptionWe report the case of a patient with stage IB2 cervical squamous carcinoma who developed multiple metastases within a short term after receiving first-line standard treatment, and she underwent interstitial brachytherapy after systemic therapy with an encouraging outcome. The patient developed suspected inguinal lymph node metastases after 9 months at the end of first-line therapy and multiple metastases in the inguinal lymph nodes, anterior abdominal wall, and right lung after 17 months. As the patient had residual inguinal lymph nodes after systemic therapy, she received 3D-printed template-guided interstitial brachytherapy to the inguinal lymph nodes and maintenance therapy. By Sep 2023, she had achieved a good treatment outcome with a progression-free survival (PFS) of 36 months.ConclusionBased on our patient response, when multiple metastases develop in the short term in early-stage cervical squamous carcinoma after first-line therapy, we may consider implementing local therapy combined with systemic therapy.
Inhibition of NOX2 or NLRP3 inflammasome prevents cardiac remote ischemic preconditioning
Authors: Benavides Sandra , Palavecino Rodrigo , Riquelme Jaime A. , Montecinos Luis , Finkelstein José Pablo , Donoso Paulina , Sánchez Gina 
Published: January 2024

Introduction: Short episodes of ischemia-reperfusion (IR) in the heart (classical ischemic preconditioning, IPC) or in a limb (remote ischemic preconditioning, RIPC) before a prolonged ischemic episode, reduce the size of the infarct. It is unknown whether IPC and RIPC share common mechanisms of protection. Animals KO for NOX2, a superoxide-producing enzyme, or KO for NLRP3, a protein component of inflammasome, are not protected by IPC. The aim of this study was to investigate if NOX2 or NLRP3 inflammasome are involved in the protection induced by RIPC.Methods: We preconditioned rats using 4 × 5 min periods of IR in the limb with or without a NOX2 inhibitor (apocynin) or an NLRP3 inhibitor (Bay117082). In isolated hearts, we measured the infarct size after 30 min of ischemia and 60 min of reperfusion. In hearts from preconditioned rats we measured the activity of NOX2; the mRNA of Nrf2, gamma-glutamylcysteine ligase, glutathione dehydrogenase, thioredoxin reductase and sulfiredoxin by RT-qPCR; the content of glutathione; the activation of the NLRP3 inflammasome and the content of IL-1β and IL-10 in cardiac tissue. In exosomes isolated from plasma, we quantified NOX2 activity.Results: The infarct size after IR decreased from 40% in controls to 9% of the heart volume after RIPC. This protective effect was lost in the presence of both inhibitors. RIPC increased NOX2 activity in the heart and exosomes, as indicated by the increased association of p47phox to the membrane and by the increased oxidation rate of NADPH. RIPC also increased the mRNA of Nrf2 and antioxidant enzymes. Also, RIPC increased the content of glutathione and the GSH/GSSG ratio. The inflammasome proteins NLRP3, procaspase-1, and caspase-1 were all increased in the hearts of RIPC rats. At the end of RIPC protocol, IL-1β increased in plasma but decreased in cardiac tissue. At the same time, IL-10 did not change in cardiac tissue but increased by 70% during the next 50 min of perfusion.Conclusion: RIPC activates NOX2 which upregulates the heart’s antioxidant defenses and activates the NLRP3 inflammasome which stimulates a cardiac anti-inflammatory response. These changes may underlie the decrease in the infarct size induced by RIPC.
Nutrient addition alters plant community productivity but not the species diversity of a mountain meadow in Tajikistan
Authors: Mekhrovar Okhonniyozov , Li Yao-ming , Abdullo Madaminov , Sino Yusupov , Fan Lianlian 
Published: January 2024

IntroductionTajikistan is a typical mountainous country covered by different mountain grasslands that are important pasture resources. Recently, grassland degradation has become widespread due to climate change and human activities and fertilization has been used to improve grassland production. However, fertilizer inputs can substantially alter species diversity, but it is uncl\ear how productivity and species diversity respond to nutrient enrichment in the mountain meadows of Tajikistan.MethodsTherefore, a 5-year (2018–2022) continuous in-situ mineral fertilizer experiment was conducted to examine the effects of three nitrogen (N) levels (0, 30, and 90 kg N ha–1 year–1), two phosphorus (P) levels (0 and 30 kg P ha–1 year–1), and their combinations on above-ground biomass (AGB) and species diversity in a mountain meadow grassland in Ziddi, Varzob region, Tajikistan. Five species diversity metrics—Margalef’s species richness (Dma), the Shannon–Wiener index (H), the Simpson index (C), Pielou’s equitability index (Epi), and the Evar Species Evenness index (Evar)—were used to measure species diversity.Results and discussionsThe results indicated that the addition of different N and P amounts and their various combinations considerably increased both total and dominant species AGB, with the highest increase occurring in the N90P30 (90 kg N ha–1 year–1 combined with 30 kg P ha–1 year–1) treatment in 2022; during the experiment, the importance value of Prangos pabularia (dominant species) first decreased and then increased, but its dominant status did not change or fluctuate among the years. Furthermore, N, P, and their different combinations had no significant effect on species diversity (Dma, H, C, Epi, and Evar). All the species diversity indexes fluctuated among years, but there was no interaction with mineral fertilizer addition. Total AGB had a negative relationship with species diversity and low concentration N fertilizer addition (N30; P30) strengthened this negative trend. However, this trend decreased under the high N fertilizer condition (N90P30). Overall, nutrient addition to the natural mountain grassland of the Varzob region improved AGB, which meant that there was more forage for local animals. Mineral fertilizers had no significant effect on species diversity, but may enhance P. pabularia dominance in the future, which will help maintain the stability of the plant community and improve the quality of the forage because P. pabularia is an excellent and important winter fodder. Our study suggests that scientific nutrient management could effectively promote grassland production, conserve plant variety, and regenerate degraded grassland, which will counteract the desertification process in northwest Tajikistan mountain meadows.
Cyberbullying and mental health: past, present and future
Authors: Bansal Suhans , Garg Naval , Singh Jagvinder , Van Der Walt Freda 
Published: January 2024

PurposeCyberbullying has attracted the world's attention, and therefore researchers across the world have contributed to the literature on cyberbullying and mental health. Amongst others, they have conducted bibliometric analyses and associated cyberbullying with various factors but have not determined the impact of cyberbullying on people's mental health. Hence, the aim of this study was to conduct bibliometric analyses of cyberbullying and mental health to analyze the academic performance of the literature on impact of cyberbullying on people's mental health; and to propose future research avenues to make further contributions to this field of study.MethodologySpreadsheets and VOSviewer were used to conduct the bibliometric analysis. The data were extracted from the SCOPUS database which provided an extensive collection of data and journals.FindingsHaving explored the top active countries publishing on the impact of cyberbullying on people's mental health and the academic performance of such research articles by means of a qualitative bibliometric analysis, the results revealed that this research topic is still to be researched extensively. The study also suggests countries/regions where this research topic can be explored further, as well as possible journals for publication of research results, and further studies to be conducted.DiscussionThe literature presents a fragmented view on the impact of cyberbullying on people's mental health. Studies on cyberbullying are limited for the reasons as discussed in this article. Hence, bibliometric analysis was conducted to analyze the performance of academic literature on the impact of cyberbullying on people's mental health; the academic performance of research articles on cyberbullying and mental health; and to make proposals toward a future research agenda.
Using temperament and character dimensions (TCI) to analyze the personality profiles of adults and older adults with cancer managed in outpatient settings
Authors: Vespa Anna , Giulietti Maria Velia , Fabbietti Paolo , Di Rosa Mirko , Gattafoni Pisana , Berardi Rossana , Arnaldi Giorgio , Balercia Giancarlo , Spatuzzi Roberta 
Published: January 2024

IntroductionThis study aimed to investigate profiles of personality evaluated by temperament and character dimensions (TCI) in 638 adult and older adult patients (CP) who had recently been diagnosed with breast, colon, lung, and other kinds of cancer (female and male subjects were assessed). Tests: Temperament and Character Inventory (TCI). Statistical analysis: cluster K-means analysis for personality traits.ResultsTwo different personality profiles emerged: “Low self-determination and pessimism” (Profile 1) and “Self-determination and self-caring (medium)” (Profile 2). The following significant differences were observed in the TCI dimensions between the two profiles: Temperament-Novelty-Seeking (NS) (p &lt; 0.001); Harm-Avoidance (HA) (p &lt; 0.001); Reward-Dependence (RD) (p &lt; 0.001); Persistence (PS) (p &lt; 0.001); Character-Self-Directness (SD) (p &lt; 0.001); Cooperativeness (C) (p &gt; 0.001); Self-Transcendence (ST) (p &lt; 0.001). No differences in the two profiles were found between adult and elderly patients. Profile 1 - “Low self-determination and pessimism”: Patients with this profile present low resistance to frustration, poor search for novelty and solutions (NS), anxiety and pessimism (medium HA), high social attachment and dependence on the approval of others (medium-high RD), and low self-determination (PS) as temperament dimensions; and medium-low self-direction, low autonomy and ability to adapt (SD-medium-low), medium cooperativeness (C), and low self-transcendence (ST) as character dimensions. Profile 2 - “Self-determination and self-caring (medium)”: Patients with this profile have resistance to frustration, ability to search for novelty and solutions (medium-NS), low anxiety and pessimism (HA), low social attachment and dependence on approval (medium-low-RD), and determination (medium-high PS) as dimensions of temperament; and autonomy and capacity for adaptation and self-direction (SD), capacity for cooperation (high-CO), and self-transcendence (medium-high-ST) as character dimensions.ConclusionPersonality screening allows a better understanding of the difficulties of the individual patient and the planning of targeted psychotherapeutic interventions that promote quality of life and good adaptation to the disease course.
Impact of motor self-efficacy on cyberbullying in adolescents and pre-adolescents in physical education
Authors: Rojo-Ramos Jorge , Castillo-Paredes Antonio , Mayordomo-Pinilla Noelia , Galán-Arroyo Carmen 
Published: January 2024

IntroductionIn recent years, cyberbullying rates have increased, especially among adolescents in the school environment. According to the literature, the factors that influence this type of behavior are access to technologies, physical activity and BMI, among others.AimThe aim is to find correlations between motor self-efficacy and cyberbullying.MethodsThe ECIP-Q and E-AEM questionnaire was applied to 1,232 students from Spanish schools and institutes (8–18 years old) in a cross-sectional study.ResultsSignificant inverse correlations were found between the ECIP-Q and the E-AEM on the variables of gender, educational stage, daily physical activity, BMI, telephone ownership and hours spent on the Internet.ConclusionIn conclusion, it can be understood that the higher the level of self-efficacy, the lower the level of abuse and victimization. Therefore, physical activity could be considered to act as a regulator of cyberbullying. And it would be interesting for public administrations to increase the number of hours of physical education, to expand out-of-school physical activities and to promote an active lifestyle in order to eradicate this type of abusive school behavior.