bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulphide petrology and ore genesis of the stratabound Sheep Creek sediment-hosted Zn–Pb–Ag–Sn prospect, and U–Pb zircon constraints on the timing of magmatism in the northern Alaska Range
Authors: Dusel-Bacon Cynthia , Aleinikoff John N. , Paradis Suzanne , Slack John F. 
Published: December 2023

The Sheep Creek prospect is a stratabound Zn–Pb–Ag–Sn massive sulfide occurrence in the Bonnifield mining district, northern Alaska Range. The prospect is within a quartz–sericite–graphite–chlorite schist unit associated with Devonian carbonaceous and siliceous metasedimentary rocks. Volcanogenic massive sulfide (VMS) deposits in the district are hosted in felsic metavolcanic rocks (362 ± 2 Ma) associated with siliciclastic and carbonaceous sedimentary rocks that overlie the stratigraphic sequence hosting the Sheep Creek prospect. Felsic metaigneous rocks in underlying units are 372 ± 4 to 366 ± 4 Ma. Sheep Creek is atypical of the other sulfide deposits in the district in (1) having Sn grades up to 1.2%; (2) being contained in fine-grained, quartz-rich rocks and quartz–pebble conglomerate that likely originated as chert and chert-clast sediment, respectively; and (3) showing minimal evidence of volcanic components in the host rocks. Comparison of immobile trace-element proportions for graphitic and siliceous rocks from the Sheep Creek area with those for argillite associated with the Bonnifield VMS deposits indicates a continental volcanic-arc provenance for the former and a within-plate and passive margin provenance for the latter. In contrast to previously published interpretations, our data analysis supports a clastic-dominated (CD) rather than a VMS affinity for the Sheep Creek prospect. In our model, Zn–Pb–Ag–Sn mineralization formed by syngenetic or early diagenetic processes on or beneath the seafloor, possibly in the shallow-water environment of an outer continental shelf setting. Potential analogues are the Paleozoic CD deposits in the Canadian Selwyn Basin outboard of the Laurentian continental margin.
Integrable scattering theory with higher derivative Hamiltonians
Authors: Fring Andreas , Turner Bethan 
Published: December 2023

AbstractWe discuss how a standard scattering theory a of multi-particle theory generalises to systems based on Hamiltonians that involve higher-order derivatives in their quantum mechanical formulation. As concrete examples, we consider Hamiltonian systems built from higher-order charges of Calogero and Calogero-Moser systems. Exploiting the integrability of these systems, we compute the classical phase shifts and briefly comment on the quantum versions of these types of theories.
Overtaking interactions in a strongly coupled inhomogeneous dusty plasma: the role of polarization force
Authors: Abd-Elzaher M. , Atteya A. 
Published: December 2023

AbstractThe nonlinear propagation of dust-acoustic waves (DAWs) is considered in a collisionless, inhomogeneous, weakly and strongly coupled dusty plasma composed of negatively charged dust, electrons, and ions. The reductive perturbation method is used to derive a Korteweg–de Vries equation (KdV). It is found that the KdV solitons are affected by the plasma parameters, whereas only rarefactive DAWs are obtained. Hirota’s bilinear approach is used to investigate the overtaking collision of two and three-soliton solutions. Physical parameters such as polarization, and the ions and electrons density gradient scale lengths have a significant impact and cause alterations in the behaviour of the solitons. Notably, as the polarization and ion density gradient scale length increase, the amplitude and width of the solitons decrease. Furthermore, the system parameters also affect the phase shifts of the solitons. The findings presented here have potential applications in the study of acoustic waves in compact astrophysical systems, where quantum polarization and inhomogeneity effects cannot be ignored, as well as in laboratory plasmas.
THE EFFECTS OF INDIVIDUAL ENTREPRENEURIAL ORIENTATION AND SELF-EFFICACY DIMENSIONS ON PROJECT PERFORMANCE AMONG UNIVERSITY STUDENTS
Authors: SAFARI ARSALAN , PARAST MAHOUR , PETROVSKA ILIJANA , AL-KWIFI OSAMA S. 
Published: December 2023

The literature on corporate entrepreneurship has discussed the role of entrepreneurship orientation (EO) and self-efficacy in enhancing venture creation and a firm’s growth. In contrast, the effect of EO and self-efficacy on project performance outcomes has been relatively overlooked. In this study, we examine how an individual’s entrepreneurship orientation (IEO), entrepreneurship self-efficacy (ESE), and entrepreneurship management skills (EMS) affect both entrepreneurship projects and non-entrepreneurship projects. Using a sample of 308 observations, our analyses reveal that while various dimensions of IEO, ESE, and EMS can significantly influence project performance, the effect is more pronounced for non-entrepreneurship projects. Furthermore, in all three ESE dimensions, we find that the effect on individual project performance is almost double the effect on team project performance. This implies that individuals consider their efforts and contributions to be more significant than the collective team efforts when completing a group project. This study contributes to the literature by providing a new perspective to assess the effect of each dimension of IEO, ESE, and EMS at both the individual level and the project level. For students, entrepreneurs, and policymakers, this study presents important insights into two areas: the influence of entrepreneurship education on an individual’s performance on individual projects and team projects; and how entrepreneurial characteristics can be nurtured to produce good entrepreneurs and project managers. This is especially significant for emerging countries, where entrepreneurship education plays a key role in supporting economic transition, promoting the private sector, and encouraging the establishment of small- and medium-sized enterprises (SMEs).
PATHOMORPHOLOGICAL CHANGES IN THE LIVER CAUSED BY HEPATITIS B, C, B+C VIRUSES IN THE DECEASED HIV-INFECTED PERSONS
Authors: Prokopovych M. V. , Hryzhak I. H. , Bahrii M. M. , Kostyuk V. M. 
Published: December 2023

Pathohistological peculiarities of liver histological preparations of 75 HIV-infected deceased people with chronic viral hepatitis which diagnosed during their life: hepatitis B was in 8, C – in 24, B+C – in 43 patients. It was determined that in all patients (100.0 %), with any type of chronic hepatitis (B, C or B+C) there was a lymphocyte-macrophage infiltration of portal tracts and stroma. In persons with hepatitis B there were a focal and periportal necrosis of hepatocytes in 100.0 % of patients, hydropic dystrophy of hepatocytes - in 87.5 % and liver cirrhosis – in 25.0 %. In patients with hepatitis C a fatty dystrophy of the liver was found in 91.7 % that more often than in patients with hepatitis B (12.5 %, p<0.001), the focal periportal necrosis of hepatocytes was less (12.5 % vs. 100.0 %, respectively, p<0.001) and liver cirrhosis was in 41.7 %.
In patients with hepatitis B+C, the liver tissue included signs characteristic of both hepatitis B and C: a hydropic dystrophy (69.8 %), fatty dystrophy (30.2 %), periportal bridging necrosis (51.2 %), liver fibrosis (34.9 %). As a result of these complex pathological processes in the liver, a cirrhosis was found more often than in other groups of patients (67.4 % vs. 41.7 % of patients with hepatitis C, p=0.041, and vs. 25.0 % of patients with hepatitis B, p=0.024). Histology activity index of hepatitis and stage of liver fibrosis according to Knodell R.G. (1981) did not differ in frequency in all groups of patients. In all patients a strong negative correlation was found between them (r=-0.607, p<0.001). This finding reflects a decrease in the histological activity of hepatitis against the background of increased fibrotic changes in the body.
Conclusion. It has been found that the hydropic dystrophy and focal intralobular and periportal bridging necrosis of hepatocytes are characteristic of hepatitis B infection in HIV-infected deceased persons. Hepatitis C is characterized by the fatty dystrophy and cirrhosis of the liver. The presence of hepatitis B+C causes the liver changes characteristic of both hepatitis B and C simultaneously: the hydropic dystrophy, fatty dystrophy, necrosis of hepatocytes. The liver cirrhosis is most often present in patients with hepatitis B+C. The degree of liver fibrosis negatively correlated with the histology activity index of hepatitis.
ОСОБЛИВОСТІ БЕШИХИ ОБЛИЧЧЯ НА ТЛІ ВТОРИННОГО ІМУНОДЕФІЦИТУ
Authors: Копча В. С. 
Published: December 2023

Описано випадок первинної бешихи обличчя в імуноскомпрометованої особи. У представленому випадку діагноз бешихи обличчя був утруднений через нетиповість клінічних і лабораторно-інструментальних проявів, зумовлену, очевидно, вторинним імунодефіцитом:

початок хвороби без продрому не з проявів загальної інтоксикації, а безпосередньо із локального ураження шкіри, що випередило гарячку на 2 доби;
відсутність класичної еритеми у вигляді язиків полум’я і чітких меж ділянки запалення без периферійного валика;
бешиха обличчя набуває вигляду метелика: майже симетрична еритема вилиць, яка, однак, суттєво поступається набряку, що поширюється за межі еритеми і значніший у місцях з розвинутою підшкірною клітковиною (передусім повіки);
відсутність нейтрофільного лейкоцитозу із зрушення формули вліво;
ділянки гіпертермії на термограмі не яскраві, перепад температури не досягає значних цифр (ΔТ=0,8-1,1 °С проти 3-8 °С за відсутності імунодефіциту);
нормалізація термографічної картини суттєво відстає від клінічних ознак реконвалесценції, що вимагає подовження антибіотикотерапії та/або її доповнення чи зміни препарату.

Розпізнавання подібних випадків важливе для забезпечення швидкого та адекватного терапевтичного втручання.
СУЧАСНА СИСТЕМА САНІТАРНОЇ ОСВІТИ В УКРАЇНІ ЯК СКЛАДОВА ПРОГРАМ У СФЕРІ ГРОМАДСЬКОГО ЗДОРОВ’Я
Authors: Лінніков С. В. , Миронюк І. С. 
Published: December 2023

Мета: визначити стан і місце санітарної освіти і промоції здоров’я серед населення та перспективи їх розвитку в системі громадського здоров’я України на сучасному етапі.
Матеріали і методи. У роботі використано бібліосемантичний метод та методи контент- та структурно-логічного аналізу. Матеріалами дослідження став світовий досвід розробки, реалізації інформаційно-комунікаційних кампаній у сфері громадського здоров’я, напрацьовані методологічні підходи до організації і впровадження санітарної освіти та промоції здоров’я.
Результати. Проаналізовано історичний аспект становлення санітарної освіти як важливого і самостійного напряму роботи системи громадського здоров’я. Критично осмислено сучасні підходи до визначення детермінант здоров’я як базису формування підходів до змістовного наповнення санітарної освіти. Окреслено сучасне бачення дефініцій обізнаності з питань здоров’я та проаналізовано структурно-функціональне наповнення сучасних моделей освіти з питань здоров’я. Визначено стан санітарної освіти в Україні, її проблемні моменти й окреслено напрями можливого розвитку.
Висновки. Потенціал санітарної освіти як інструменту соціальних змін політичної діяльності в сучасній охороні здоровʼя було дещо забуто. Сьогоднішнє розуміння санітарної освіти було обмежене міжособистим спілкуванням та медіа-кампаніями, спрямованими на індивідуальні здоровʼязберігаючі практики і дії та використання профілактичних медичних послуг. Якщо досягнення санітарної освіти, як визначено Всесвітньою організацією охорони здоровʼя, є ціллю, то потрібно провести певну переоцінку важливості санітарної освіти, а також значного розширення змісту і методів, які використовуються.
РОЗБУДОВА СПРОМОЖНОСТЕЙ ІЗ ПІДГОТОВКИ МАГІСТРІВ ГРОМАДСЬКОГО ЗДОРОВ’Я В ТЕРНОПІЛЬСЬКОМУ НАЦІОНАЛЬНОМУ МЕДИЧНОМУ УНІВЕРСИТЕТІ ІМЕНІ І. Я. ГОРБАЧЕВСЬКОГО МОЗ УКРАЇНИ
Authors: Сатурська Г. С. , Ульрікс Т. , Лаксі М. , Шульгай А. Г. , Фельдманн Г. , Петрашик Ю. М. 
Published: December 2023

Мета: дослідити історію зусиль та заходів із розвитку спроможностей із підготовки магістрів громадського здоров’я в Тернопільському національному медичному університеті імені І. Я. Горбачевського МОЗ України.
Матеріали і методи. Методологічною основою дослідження є аналіз наукових публікацій і даних архівних матеріалів із застосуванням історико-бібліографічного методу.
Результати. У Тернопільському національному медичному університеті імені І. Я. Горбачевського МОЗ України було успішно розвинуто спроможності з підготовки магістрів громадського здоров’я. Історія розвитку магістерської програми «Громадське здоров’я» свідчить про спрямованість на постійну еволюцію та адаптацію до змін суспільних потреб. Створена відповідно до вимог часу, магістерська програма відзначилася значущими досягненнями у підготовці кваліфікованих фахівців галузі громадського здоровʼя. Магістерську програму «Громадське здоров’я» у ТНМУ запроваджено у 2019 р., і з того часу успішно пройдено акредитацію (2020), здійснено 3 випуски фахівців та проведено 5 наборів на навчання здобувачів вищої освіти, кількість яких демонструє позитивну динаміку (2019 р. – 11 здобувачів, 2020 р. – 6, 2021 р. – 6, 2022 р. – 41, 2023 р. – 31). З 2019 по 2023 р. захищено 23 магістерські роботи.
Висновки. Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України безперервно працює над розвитком спроможностей із підготовки магістрів громадського здоров’я. Сьогодні програма підготовки магістрів громадського здоров’я є важливим складником навчального процесу університету.
Abstract 13338: Intravenous Iron for Patients With Iron Deficiency and Acute or Chronic Heart Failure, a Meta Analysis
Authors: K. Awad Ahmed , Abdeljalil Mahmoud Shabaan , Mouffokes Adel , Elbadawy Merihan A , K. Awad Ayman , Nabeel Ambreen , Gardezi Syed Karam , Awan Rehmat Ullah 
Published: December 2023

Iron deficiency is very common in heart failure (HF), both with preserved and reduced ejection fraction (HFp/rEF); and has significant impact on both symptoms and prognosis. This review highlights the effect of use of intravenous iron (IVI) therapy in patients with HFrEF
Several databases were searched to identify RCTs that investigate the efficacy and safety of IVI therapy in patients with acute or chronic HF. A meta-analysis was performed using RevMan using random effect model. We used the odds ratio (OR) and mean difference (MD) for dichotomous and continuous outcomes, respectively presented with the corresponding 95% confidence interval (CI).
A total of 18 studies were included with 3,436 patients with mean age of 68 years old. There was no statistically significant difference between IVI and placebo in terms of cardiovascular death or all-cause hospital admission. However, IVI was associated with statistically significant lower risk for hospitalization for any cardiovascular disorder and all cause death with OR 0.42 [95% CI 0.28, 0.64, p<0.0001] and 0.61 [95% CI 0.39, 0.96, p=0.03], respectively. Additionally, there was statistically significant variation in serum ferritin and serum transferrin from baseline favoring intravenous iron with MD -189.62 [95%CI -236.55, -142.69, p=0.01], and -7.65 [95% CI -13.43, -1.87, p=0.009], respectively. Furthermore, IVI was associated with a significant improvement in HF patients’ functional status, evaluated by both Kansas City Cardiomyopathy Questionnaire (KCCQ), and changes from baseline in left ventricular ejection fraction (LVEF) with MD -7.14 [95% CI -10.52, -3.76, p<0.0001], and 3.76 [95% CI 2.32, 5.21, p<0.00001], respectively.
Our meta-analysis demonstrated the capability of IVI to improve clinically meaningful outcomes as HF-related cardiovascular-related hospitalization as well as functional status; however, intravenous iron showed no difference in term of mortality.
Abstract 14254: Myocarditis in Athletes and Non-Athletes: Evaluating the Persistence and Degree of Myocardial Fibrosis at Follow Up
Authors: Abela Mark , Demanuele Joseph , Buttigieg Lisa , Farrugia Mark , Borg Bernard , Yamagata Lara , YAMAGATA KENTARO , Borg Alexander 
Published: December 2023

Introduction:
Myocarditis is a common acquired cardiac disorder that may lead to persistent scar. Current guidelines recommend follow up cardiac MRI (CMR) in 3-6 months for athletes. Data supporting this recommendation is unfortunately very limited.

Aim:
The aim of this study was to evaluate the demographic and clinical variables of patients diagnosed with myocarditis. Clinical data for those who had a follow up CMR was also evaluated separately.

Methodology:
Patients who had a cardiac MRI (CMR) organised between July 2019 till December 2022 because of a MINOCA/Myocarditis hospital admission were retrospectively reviewed. Those with a myocarditis diagnosis were included. An athlete was defined as an individual who engaged in >4 hours of physical activity weekly or underwent organized sport.

Results:
105 patients were included (mean age 35.4±15.6 years, 83.8% male). 34.3% were athletes. 12.4% had possible acute myocarditis, 10.5% had likely myocarditis and 77.1% had confirmed myocarditis on cardiac MRI (median 4 days from presentation). ECG was abnormal in 60.0%. 8.6% had arrhythmias. Echocardiography was abnormal in 26.7%. CMR revealed 15.2% reduced LV EF, 57.1% regional wall motion abnormalities, 5.7% reduced RV EF, 25.7% pericardial effusion, 84.5% myocardial oedema. Most (88.5%) had late gadolinium enhancement (LGE). 56.2% were started on anti-heart failure medical therapy.

29.5% had a CMR repeated (interval between scans 14.7±14.2 months). 77.4% showed persistent LGE, less pronounced in most (71.0%). Diffuse LGE at baseline was the only predictor for persistent scar (p=0.004). Scar persisted equally in athletes and non-athletes (p=0.666). Clinical variables were similar in both.
At follow-up (24.6±15.3 months), 8.6% had adverse outcomes. The event rate was similar in athletes and non-athletes. A low LV EF on CMR (p=0.011) and abnormal ECHO (p=0.027) were the only variables that could predict outcome.

Conclusion:
LGE after myocarditis persists in 77.4% of cases, albeit better. No variable could predict the persistence of LGE in this cohort. Athletes and non-athletes had a similar clinical course, suggesting that repeat CMR in non-athletes is reasonable. The diagnostic utility of repeat CMR after myocarditis remains questionable.
Abstract 14933: A Rare Case of Cardiac Angiosarcoma Presenting as Hemorrhagic Pericardial Effusion
Authors: Mansour Christina , Jun Judy , Ranches Gregory 
Published: December 2023

Cardiac sarcomas are exceptionally rare, with an incidence of only 0.02% and comprising less than 1% of all primary cardiac tumors. Consequently, diagnosis of the disease can be challenging due to non-specific presenting symptoms and diverse clinical manifestations. We present a unique case of cardiac sarcoma that highlights these challenges.
A 70-year-old man with a history of hypertension, hyperlipidemia, and latent tuberculosis presented with palpitations, chest pain, and dyspnea, was found to have hemorrhagic pericardial effusion with tamponade. Pericardial fluid studies were negative for malignancy, and echo not suggestive of cardiac mass or pericardial abnormalities. He presented several months later with hemoptysis and was found to have innumerable pulmonary nodules on CT chest and a mediastinal mass adjacent to the right atrium. Bronchoscopy was negative for infection or malignancy. Ultimately the patient underwent CT-guided lung biopsy, which showed a malignant spindle cell neoplasm with a positive stain for vimentin and vascular markers suggestive of angiosarcoma of unknown primary. Given unclear relation of his mediastinal mass, cardiac MRI was done which showed a rapidly enhancing bulky neoplasm with abnormal contrast enhancement arising from the lateral right atrium (Figure 1) consistent with metastatic cardiac angiosarcoma. Patient was started on systemic anthracycline-based chemotherapy; however the overall prognosis remains poor.
Given the rarity of cardiac sarcomas, prognosis is generally poor due to the advanced stage at the time of diagnosis. These tumors exhibit aggressive behavior and have a high propensity for metastasis. Due to their infrequency, knowledge and research is limited regarding effective treatments. This case highlights the significance of considering cardiac angiosarcoma in cases of hemorrhagic pericardial effusion even in the absence of obvious cardiac mass or pericardial nodularity on initial presentation.
Abstract 16589: Predicting Cardiovascular Risk in Participants Treated With Tirzepatide in the SURPASS 1-5 Trials
Authors: Wiese Russell J , Wang Hui , Mody Reema , Benneyworth Brian D 
Published: December 2023

Predicting atherosclerotic cardiovascular disease (ASCVD) risk considers factors that individually influence the likelihood of experiencing a major cardiovascular (CV) event. Tirzepatide (TZP) is a GIP and GLP-1 receptor agonist that improved risk factors such as lipid profile and systolic blood pressure across the Phase 3 SURPASS T2D program. We compared the effect of TZP versus the comparator on calculated ASCVD risk from baseline to endpoint in each of the 5 SURPASS (S) studies.
We assessed the ASCVD risk in T2D participants without CVD history from S 1-5 studies using an American College of Cardiology/American Heart Association risk engine. The risk engine considers the factors: sex, age, race, total cholesterol, high density lipoprotein, systolic blood pressure, antihypertensive medication use, smoking and diabetes status. Risk scores and categories are summarized by treatment group.
The baseline characteristics vary between studies (female sex ranges from 44.9% to 54.6%, mean age in years ranges from 53.6 to 64.3) but were similar among treatment groups within each study. The median baseline risk score across the TZP dose range were 6.5-11.5 for S-1, 9.3-10.8 for S-2, 12.4-15.4 for S-3, 22.9-26.0 for S-4, and 14.8-19.1 for S5. At the primary endpoint (40 or 52 Weeks), the ASCVD risk category for 10.9-21.4% of TZP-treated participants improved versus 2.9-12.7% for placebo/comparator (Table). Also, the risk category for 1.2-9.4% of TZP-treated participants worsened versus 6.3-14.9% for placebo/comparator. The median CV risk score was decreased in all TZP treatment groups while the median CV risk score was increased in the placebo/basal insulin groups. In SURPASS-2, the decreases in CV risk score were qualitatively greater in the TZP groups compared to the semaglutide group.
TZP treatment lowers CV risk and significantly more participants shift to a lower CV risk category when compared to placebo, basal insulins, and semaglutide.