bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Positive Leadership on Intrinsic Motivation of Inter-professional Collaboration among Medical Staff : A Moderated Effect of Culture
Authors: Zhang Hao , Wu Yan , Hu Zhuomu , Huang Zhen , Wang Jialin , Wu Mengjie , Cao Menglei , Sun Tao 
Published: October 2023

Abstract

Background
Inter-professional collaboration (IPC) is critical to address the issues of fragmented healthcare; however, intrinsic motivation of IPC among medical staff is at a low level. Positive leadership is supposed to have an inference on the intrinsic motivation of IPC; however, the mechanism is not clear at present.
Methods
this study explored the effect of positive leadership on intrinsic motivation of IPC of medical staff, as well as the moderating role of culture, from 1324 valid questionnaires of medical staff in China, with SEM, hierarchical linear regression, simple slope test.
Results
The SEM results indicated that positive leadership had a direct effect on self-efficacy and a mediating effect on self-efficacy via career identity and achievement motivation. The hierarchical linear regression analysis showed that the interactive items of positive leadership and culture had a positive effect on career identity (β = 0.089), indicating that culture has a positive moderating effect on the relationship between positive leadership and career identity. The simple slope test indicated that in the hospitals, positive leadership had a significant effect on career identity for both the high level of culture group (β = 0.382) and the low level of culture group (β = 0.297).
Conclusion
These findings suggest that the positive leadership promotes the intrinsic motivation of IPC, while culture plays a moderating role in the relationship between positive leadership and career identity.
Urban Growth and Landscape Change in Three Bangladesh Cities: Dhaka, Chattogram, and Sylhet
Authors: Jahan Israt , DeLiberty Tracy , Walter Matthew , Mondal Pinki 
Published: October 2023

Abstract

Bangladesh is one of the fastest-growing developing countries in the world, experiencing rapid unplanned and haphazard urbanization. This unplanned development leads to environmental degradation, threatening ecosystems and human well-being. Planned urbanization is vital in reducing ecosystem stress and ensuring sustainable urban development. An intensive study of the urbanization patterns over the last 20 years will aid in future development planning to ensure a better living environment. Our study examines the urbanization trend over the last two decades in Bangladesh's three main cities: Dhaka, Chattogram (previously called Chittagong), and Sylhet. The study compares each city's growth within its present municipal boundary and surrounding periphery buffer area. The municipal authority designates this buffer area as the future city expansion area. These three cities' land surfaces were classified using Landsat 5 and Landsat 8 satellite data (spatial resolution: 30m) on the Google Earth Engine (GEE) cloud computing platform. Using a three-year composite image, a pixel-based Random Forest (RF) supervised classification was used for land use classification, achieving an overall accuracy of over 94%. In 2021, the core city area of Dhaka was 47% built-up, Chattogram was 37%, and Sylhet was 49%. Comparatively, the cities' proposed future expansion area is less built-up, with impervious areas covering only 18% in Dhaka, 13% in Chattogram, and 19% in Sylhet. Over the last two decades, Dhaka experienced the most significant change (65%) across all the land use types, with Sylhet second at 52% change and Chattogram at 48%. Following this trend, municipal authorities can preplan for accommodating the increased urban population in a sustainable manner, parallelly reducing the adverse impacts of unplanned city growth.
Systemic and cyber-physical methodology for the implementation of Industry 4.0 in Mexican automotive manufacturing companies
Authors: Romeo Lorenzo L. González , Reyes Juan Bory , Ramírez Jorge A. Rojas 
Published: October 2023

Abstract

The transition toward the new technological paradigm in production systems resulting from Industry 4.0 (hereinafter I4.0) pursues, among its main objectives, greater operational efficiency and productivity, a greater scope of automation, customization, and flexibility in production, an increase in man-machine interaction, and the creation of more complex but better-paid jobs and new business models. For this reason, a broad understanding of what constitutes I4.0 today and what can represent the future requires knowledge about the technologies that make it up, as well as different tools that can help to carry out a correct and comprehensive implementation. The relevance of the Mexican automotive manufacturing industry in the national economy, as well as the importance of the I4.0 transition in this sector, is addressed. As a fundamental component of this work, a new methodology with a systemic character, given by the use of the Soft Systems Methodology, and with a cyber-physical character, given by the use of tools such as a Reference Architecture, is presented, and the tools used and its different stages are described. As an added element, an illustrative example is provided of how the application of the proposed methodology would be in an automotive manufacturing company.
Efficacy and safety of percutaneous ultrasound-guided thermal ablation in the treatment of cervical metastatic lymph nodes from papillary thyroid carcinoma
Authors: Zhang Shen , Liu Yunyun , Zhou Bangguo , Xu Hui-Xiong 
Published: October 2023

Abstract

Purpose This study aimed to evaluate the efficacy and safety of percutaneous ultrasound-guided thermal ablation in the treatment of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma (PTC).Methods A total of 77 patients with 79 LNs ablated by microwave ablation (MWA) or radiofrequency ablation (RFA) between September 2018 and October 2022 were enrolled in this study. After treatment, patients were followed up with measurement of diameters of LNs and serum thyroglobulin (s-Tg) at 1, 3, 6, and 12 months and annually thereafter. The paired t-test was used to compare the changes of s-Tg level, diameters of LNs before and after ablation.Results There were no serious complications related to ablation while one case of incomplete ablation in MWA was found during follow-up. The mean longest and shortest diameter of the ablated LNs reduced from 11.6 ± 4.3 mm to 5.0 ± 4.1mm (p < 0.001), and from 6.1 ± 1.9 mm to 3.0 ± 2.5 mm (p < 0.001) at the last follow-up visit. Besides, the final volume reduction rate (VRR) was 61.8 ± 56.4% (range, -67.0 -100%). The complete disappearance rate was 46.8%, but there were 4 (5.1%) LNs becoming bigger than before. The average s-Tg level was 9.2 ± 26.6 ng/mL, a data significantly decreased to 3.7 ± 7.0 ng/mL at the last follow-up, but no statistical difference was shown.Conclusion Thermal ablation is an effective and safe modality for the treatment of metastatic LNs from PTC.
The impact of obesity on chronic oedema/lymphoedema of the leg – An international multicenter cross-sectional study (LIMPRINT)
Authors: Burian Ewa , Rungby Jørgen , Karlsmark Tonny , Nørregaard Susan , Cestari Marina , Franks Peter , Moffatt Christine 
Published: October 2023

Abstract
Background/Objectives: Obesity and chronic oedema/lymphoedema are two distinct but related conditions, rarely investigated together. The aim was to study the impact of increased weight on chronic oedema and related factors.
Subjects/Methods: A cross-sectional study (2014-2017), in 38 centers, nine countries. Patients with clinically confirmed chronic oedema/lymphoedema of the leg were included. Normal weight was judged as BMI 20-30, obesity BMI 30-40 or morbidly obese BMI >40. Factors were tested for an association with increased weight, using a multivariable model.
Results: In total 7397 patients were included; 43% being normal weight, 36% obese and 21% morbidly obese. Patients with increased weight had significantly more advanced stages of chronic oedema (ISL stage III; the most advanced form); affecting 14% of normal weight, 18% in obesity and 39% in morbid obesity (p<0.001). Ten factors were independently associated with increased weight: diabetes (OR 2.4), secondary lymphoedema (OR 2.7), cellulitis/erysipelas within 12 months (OR 1.2), bilateral lymphoedema (OR 3.6), compression therapy (OR 2.1), increased swelling duration (1-2 years OR 1.3, 2-5 years OR 2.5, 5-10 years OR 3.6, >10 years OR 3.5) decreased mobility (walking with aid OR 1.9, being chair bound OR 1.2) and age (reference <45 years; 45-64 years OR 1.5, 75-84 years OR 0.6, 85+ years OR 0.2). Increased weight was associated with a lower presentation of peripheral arterial disease (OR 0.7) and poorer chronic oedema control (OR 0.8). Patients with obesity/morbid obesity had a lower function, appearance and more severe symptoms as assessed by LYMQOL and lower quality of life using EuroQol.
Conclusions: Obesity negatively impacts chronic oedema, leading to more advanced stages. Achieving good control of swelling with compression is more difficult in these patients. Increased awareness of chronic oedema/lymphoedema as a complication of obesity is important for early detection and for developing effective strategies to prevent and manage them.
Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases
Authors: Tizabi Yousef , Getachew Bruk , Aschner Michael 
Published: October 2023

Abstract
Toxic exposures to heavy metals, such as iron (Fe) and manganese (Mn), can result in long-range neurological diseases and are therefore of significant environmental and medical concerns. We have previously reported that damage to neuroblastoma-derived dopaminergic cells (SH-SY5Y) by both Fe and Mn could be prevented by pre-treatment with nicotine. Moreover, butyrate, a short chain fatty acid (SCFA) provided protection against salsolinol, a selective dopaminergic toxin, in the same cell line. Here, we broadened the investigation to determine whether butyrate might also protect against Fe and/or Mn, and whether, if combined with nicotine, an additive or synergistic effect might be observed. Both butyrate and nicotine concentration-dependently blocked Fe and Mn toxicities. The ineffective concentrations of nicotine and butyrate, when combined, provided full protection against both Fe and Mn. Moreover, the effects of nicotine but not butyrate could be blocked by mecamylamine, a non-selective nicotinic antagonist. On the other hand, the effects of butyrate, but not nicotine, could be blocked by beta-hydroxy butyrate, a fatty acid-3 receptor antagonist. These results not only provide further support for neuroprotective effects of both nicotine and butyrate but indicate distinct mechanisms of action for each one. Furthermore, potential utility of the combination of butyrate and nicotine against heavy metal toxicities is suggested.
KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma
Authors: Wei Denghui , Yang Zhenyu , Peng Yanfu , Wang Yaqin , Yang Panyang , Huang Zhuohui , Quan Tingqiu , Xu Xudong , Sun Ying , Zhou Guan-Qun 
Published: October 2023

Abstract
Transcription factors (TFs) engage in various cellular essential processes including differentiation, growth and migration. However, the master TF involved in distant metastasis of nasopharyngeal carcinoma (NPC) remains largely unclear. Here we show that KLF5 regulates actin remodeling to enhance NPC metastasis. We analyzed the msVIPER algorithm-generated transcriptional regulatory networks and identified KLF5 as a master TF of metastatic NPC linked to poor clinical outcomes. KLF5 regulates actin remodeling and lamellipodia formation to promote the metastasis of NPC cells in vitro and in vivo. Mechanistically, KLF5 preferentially occupies distal enhancer regions of ACTN4 to activate its transcription, whereby decoding the informative DNA sequences. ACTN4, extensively localized within actin cytoskeleton, facilitates dense and branched actin networks and lamellipodia formation at the cell leading edge, empowering cells to migrate faster. Collectively, our findings reveal that KLF5 controls robust transcription program of ACTN4 to modulate actin remodeling and augment cell motility which enhances NPC metastasis, and provide new potential biomarkers and therapeutic interventions for NPC.
Chemically Activated Natural Clay as Effective Scavenger for Cd(II) and Co(II): Isotherms, Kinetics and Thermodynamic Evaluations
Authors: OFUDJE Edwin A. , OGUNDIRAN Abimbola A. , AKANDE James Asamu , SODIYA Ezekiel F. , ADEMOYEGUN Adeniyi John 
Published: October 2023

Abstract

The investigation of the impact of sulphuric acid activation on natural clay in Cd(II) and Co(II) ions scavenger from aqueous medium under various experimental factors was carried out. The clay samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray Fluorescent (XRF), X-ray diffraction (XRD). The FT-IR results revealed the presence of prominent absorption bands of kaolinite at 3695.63, 3627.52, 1113.54, 918.50, 790.40, 537.93, and 446.95 cm-1. The adsorption process of Co(II) demonstrated good correlation with pseudo-second-order kinetic for both adsorbents, while that of Cd(II) depicted better conformity with pseudo-first-order kinetic model indicating physical adsorption mechanism. The maximum adsorption capacities predicted by Langmuir isotherm for natural clay (NC) and chemically modified natural clay (CMNC) are 86.341 and 158.760 mg/g for Co2+, 78.221 and 136.671 mg/g for Cd2+ respectively with the activated clay showing better adsorption capacity. Values of thermodynamic parameter of ΔH° for NC and CMNC was estimated and found to be 2.534 x 106 and 2.309 x 106 kJ mol−1 for Co2+ and 1.020 x 106 kJ mol−1 and 1.591 x 106 kJ mol−1 for Cd2+ thus indicating endothermic process. The results derived from this present study revealed that the chemically modified natural clay is better adsorbent for the scavenger of Co(II) and Cd(II) ions in contaminated water over natural clay.
A Relationship Between Jet Activity and Strike-Slip Motion over the Tiger Stripes on Enceladus
Authors: Berne Alexander , Simons Mark , Keane James T. , Leonard Erin J. , Park Ryan S. 
Published: October 2023

Abstract

At Enceladus, jets along four distinct fractures, called `Tiger Stripes', erupt ice crystals into a broad plume above the South Pole. The Tiger Stripes experience variations in tidally-driven shear and normal traction as Enceladus orbits Saturn. We show that this traction may produce quasi-periodic strike-slip motion with two peaks in activity during each orbit. To the extent that friction modulates the response of Tiger Stripes to driving stresses, the tidal traction on the faults result in a difference in the magnitudes of peak strike-slip motion and cause a delay in the timing of the first peak in fault motion. The predicted double-peaked and asymmetric strike-slip motion of the Tiger Stripes closely tracks diurnal variations in jet activity inferred from Cassini images of plume brightness. The spatial distribution of strike-slip motion also matches Cassini infrared observations of heat flow which indicate maximal activity along Baghdad Sulcus and near the center of the Tiger Stripes. We hypothesize that strike-slip motion may open pull-apart structures along geometric irregularities over the Tiger Stripes and thus modulate jet activity. Tidally-driven fault motion may also influence longer term tectonic evolution near the South Pole of the satellite.
Facial nerve palsy (Bell's palsy) (a cross-sectional study)
Authors: Bakleh Frial Mohammad Mamoun , Sherkatly Joudy Ahmad samer , Al-Fawares Maamoun Ayman , AlMansour Rana Molham , Najati Ghena Mohammed Khalid 
Published: October 2023

Abstract

Objectives: Our objective was to identify the possible etiologies of facial nerve palsy while highlighting the possible psychological aspects of this condition. We also reviewed treatment recommendations and provided advice on how to avoid complications and ensure rapid recovery.
Materials and Methods: We reviewed some of the available literature on facial nerve paralysis and conducted our own survey on general knowledge of facial nerve paralysis and its possible psychological causes in people aged 15 years and over. We also provided a summary of possible causes, symptoms, diagnosis, treatment methods, and recommendations. Our study type was cross-sectional, and data were collected through electronic questionnaires.
Results: The number of participants was 200, including inclusion criteria and exclusion criteria Most of our responders were aged between 15 and 25 years. Half of them had met a person who suffered from facial nerve palsy after being exposed to some psychological distress. Most of these patients went to see a neurologist instead of seeking a psychiatrist help. And most changed their lifestyle after their injury.
Conclusion: This study emphasizes the importance of mental health support, mental health is as equally important as physical health and patients must be aware of its contribution to physical illnesses. Patients must be encouraged to seek psychiatric help in order to reduce the incidence of facial nerve palsy.
Entry of cannabidiol into the fetal, postnatal and adult rat brain.
Authors: G Fitzpatrick , Y Huang , F Qiu , Habgood  , RL Medcalf , H Ho , KM Dziegielewska , NR Saunders 
Published: October 2023

Abstract
Cannabidiol is a major component of cannabis but without known psychoactive properties. A wide range of properties have been attributed to it, such as anti-inflammatory, analgesic, anti-cancer, anti-seizure and anxiolytic. However, being a fairly new compound in its purified form, little is known about cannabidiol brain entry, especially during development. Sprague Dawley rats at four developmental ages: embryonic day E19, postnatal day P4 and P12 and non-pregnant adult females were administered intraperitoneal cannabidiol at 10 mg/kg with [3H] labelled cannabidiol. To investigate the extent of placental transfer the drug was injected intravenously into E19 pregnant dams. Levels of [3H]-cannabidiol in blood plasma, cerebrospinal fluid and brain were estimated by liquid scintillation counting. Plasma protein binding of cannabidiol was identified by polyacrylamide gel electrophoresis and its bound and unbound fractions measured by ultrafiltration. Using available RNA-sequencing datasets of E19 rat brain, choroid plexus and placenta, as well as P5 and adult brain and choroid plexus, expression of 13 main cannabidiol receptors was analysed. Results showed that cannabidiol rapidly entered both the developing and adult brains. Entry into CSF was more limited. Its transfer across the placenta was substantially restricted as only about 50% of maternal blood plasma cannabidiol concentration was detected in fetal plasma. Albumin was the main, but not exclusive, cannabidiol binding protein at all ages. Several transcripts for cannabidiol receptors were expressed in age- and tissue-specific manner indicating that cannabidiol may have different functional effects in the fetal compared to adult brain.
Expression Analysis of Genes Responsible for Rosmarinic acid Biosynthesis and HPLC Quantification Method Development and Validation of Rosmarinic acid from Isodon rugosis
Authors: khan Saira , Imtiaz Anum , Taning Clauvis Nji Tizi , Haq Ihsan Ul , Smagghe Guy , Shah Mohammad Maroof 
Published: October 2023

Abstract

Natural products from plants, either as pure compounds or as standardized extracts, offer unlimited prospects for new pesticide discovery. In screening programs, because of increased chemical diversity demand, in search of pesticides from natural products, interest mainly in harmless plants has developed all over the world. Botanicals comprise of several types of bioactive compounds. In our previous publications, bioactive pesticidal compound; rosmarinic acid (RA) was isolated from the plant, Isodon rugosus and was identified by using various analytical techniques. In this study two key genes, hydroxyphenylpyruvate reductase (HPPR) and rosmarinic acid synthase (RAS), known to involve in biosynthesis of RA were targeted to clone from Isodon rugosus. Only one of these genes, HPPR was successfully cloned in I. rugosus and its cDNA was fully sequenced through RACE (Rapid Amplified cDNA ends) PCR, which consequently will open the way to explore all other genes responsible for biosynthesis of rosmarinic acid. The expression of HPPR was analyzed in different parts of plant and it was found that RA was expressed in all parts of the plant. Further, RA quantification was performed on RP-HPLC using C18 column, giving a maximum absorbance at 310 nm in isocratic conditions. The methodology was found selective and robust to quantify 1.60+0.14gm/kg RA in I. rugosus with sensitivity of LOD 1.32 µg/ml, and LOQ 4.41 µg/ml. The molecular knowledge regarding biosynthetic pathway and significant quantity of RA in this plant will help in biotechnological production of RA and to produce insect resistant plants through genetic engineering approaches.
Design of a liposome with the property to induce CD16 on cervical cancer cells with a purified spermidine-cholesterol
Authors: Weiss-Steider Benny , Marcelin-Jiménez Gabriel , Soto-Vazquez Ramón , Ramírez Adelfo N. Reyes , Rangel-Corona Rosalva , Vargas-Angeles Carlos Adrian , Corona-Ortega María Teresa 
Published: October 2023

Abstract

Purpose Use of a purified cationic lipid for fabricate liposomes capable of inducing the appearance of CD16 receptors on the membranes of cervical carcinoma cells.Methods Chemical synthesis of purified spermidine-cholesterol; liposome fabrication; UPLC-MS analysis; Cell culture; Flow cytometry.Results The construction of a liposomal system with a highly purified spermidine-cholesterol with CD16 inducing capacity on cervical cancer cells.Conclusion We were able to synthetize a highly purified spermidine-cholesterol to fabricate a liposomal system capable to induce CD16 on cervical cancer cells.
Psychometric properties of the Meaning in Life Questionnaire in Spanish people diagnosed with Borderline Personality Disorders
Authors: García-Alandete Joaquín , Pére Sandra , Lorca-Alamar Fátima , Guillén Verónica , Marco José H. 
Published: October 2023

Abstract

This study analyzed the psychometric properties of the Meaning in Life Questionnaire (MLQ), one of the most important scales used to assess Meaning in Life (MiL), in a sample of Spanish people diagnosed with Borderline Personality Disorder (BPD). Participants were 102 Spanish people (72.55% women) from 18 years to 68 years old (M = 37.69; SD = 12.66) diagnosed with BPD, who completed the MLQ, Purpose in Life Test-10 Items (PIL-10), and Dissociative Experiences Scale II (DES-II). The bidimensional model for the MLQ showed adequate internal consistency and an excellent fit. The MLQ-P and MLQ-S scales correlated positively. The MLQ-P scale showed a positive correlation with the PIL-10 and a negative correlation with the DES-II. Introducing MiL into interventions with BPD patients can be a useful way to help them to find purpose in their lives, alleviate their existential suffering, and cope with the clinical symptomatology of BPD.