bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indefinite definites in Italian
Authors: Morosi Paolo , Espinal M. Teresa 
Published: February 2025

Abstract
This paper examines indefinite interpretations associated with morphologically definite articles in Italian, such as Ha comprato {i tulipani / l’olio} (‘She bought (the) tulips / (the) oil’), which allow both a default definite reading and an indefinite interpretation. The paper addresses two main research questions: (i) what grammatical conditions allow indefinite definites in Italian?, and (ii) why do only Italo-Romance varieties, and not other Romance languages, allow the presence of indefinite definites (in addition to bare nouns, the so called “partitive article” and even a bare di)? The primary contribution of the paper is to show that the indefinite reading of definite internal arguments in Italian cannot be derived from a weak definite approach, from kind denotation, or from an operation of derived kind predication. Instead, we argue that internal definite (plural and mass) arguments can be interpreted as conveying an indefinite reading, as long as the event in which they participate denotes incremental homogeneity (Landman and Rothstein 2010, 2012a, 2012b). This hypothesis is supported by the productivity of indefinite definites in habitual (and iterative) contexts, which are incrementally homogeneous by definition; and their compatibility with per ‘for’ (and ogni ‘every’ N) temporal modifiers. Concerning the cross-linguistic and cross-dialectal puzzle, the paper highlights that the use of indefinite definites for the expression of weak indefiniteness reveals the bidirectional influence between dialectal substrata and the national language, giving prominence to the role of competing grammars in speakers of informal Italian.
Fluoride Exposure Increases the Activity of the Cystine/Glutamate Exchanger in Glia Cells
Authors: Ocharán-Mercado Andrea , Loaeza-Loaeza Jaqueline , Hernández-Sotelo Daniel , Cid Luis , Hernández-Kelly Luisa C. , Felder-Shmittbuhl Marie-Paule , Ortega Arturo 
Published: February 2025

Abstract
Fluoride exposure in drinking water has been widely related to impairment of cognitive function. Even though this ion has been described as neurotoxic for more than two decades, the molecular mechanisms of fluoride neurotoxicity are not fully understood, however, increasing evidence suggests that glial cells are the site of early injury in fluoride neurotoxicity. Nevertheless, a convergence point of many studies is the effect on glutamatergic neurotransmission and the generation of reactive oxygen species. In this context, we evaluated here the expression and regulation of the cystine/glutamate exchanger upon fluoride exposure since this transporter is in the interface between excitotoxicity and the antioxidant response. We demonstrate here the functional expression of the cystine /glutamate exchanger in both the U373 human glioblastoma cells and chick cerebellar Bergmann glia cells. Using a [3H]-L-Glutamate uptake assay, we demonstrate that fluoride increases the activity of the exchanger in a time and dose-dependent manner. This augmentation is mitigated by the antioxidant Trolox. To gain insight into fluoride neurotoxicity mechanisms, we evaluated its effect on human antigen R, a RNA binding protein, that binds to the 3'-UTR region of exchanger mRNA increasing its half time life. An increase in human antigen R protein was recorded after a 6 h fluoride exposure, suggesting that this ion regulates the exchanger through this RNA-binding protein. Furthermore, we show that fluoride exposure increases both the exchanger and human antigen R mRNAs half-life. These results provide insights into fluoride neurotoxicity mechanisms and support the notion of a central role of glial cells in neuronal glutamatergic transmission disruption that leads to neuronal cell death.
Associations between financial toxicity, health-related quality of life, and well-being in Indonesian patients with breast cancer
Authors: Pangestu Stevanus , Purba Fredrick Dermawan , Setyowibowo Hari , Mukuria Clara , Rencz Fanni 
Published: February 2025

Abstract

Objectives
Financial toxicity (FT) is the impairment of financial well-being experienced by patients with cancer, categorized into subjective (SFT) and objective (OFT) forms. This study aimed to investigate the associations between FT, health-related quality of life, and overall well-being in patients with breast cancer.

Methods
We analyzed baseline data from a single-center longitudinal study in Indonesia. Patients completed the EQ-5D-5L, EQ Health and Wellbeing (EQ-HWB), COST: A FACIT Measure of Financial Toxicity (FACIT-COST, for measuring SFT), and OFT-related questions. Ordinal logistic regression was used to examine the associations between FT and selected EQ-5D-5L and EQ-HWB items. Multivariable linear regression was used to assess the associations of FT and EQ-5D-5L and EQ-HWB-S index values. The main regression models were adjusted for socio-demographic and clinical factors such as age, income, metastasis status, and symptoms.

Results
The survey included 300 female patients with breast cancer undergoing treatment (mean age = 51). Overall, 21% experienced high SFT (FACIT-COST ≤ 17.5) and 51% reported any OFT (e.g., incurring debt). Adjusted for covariates, higher SFT was associated with more problems in EQ-5D-5L pain/discomfort and anxiety/depression, and in EQ-HWB exhaustion, anxiety, sadness/depression, frustration, pain, and discomfort. OFT was associated with more problems in exhaustion. Higher SFT was associated with lower EQ-5D-5L and EQ-HWB-S index values, with explained variances of 46.3% for EQ-HWB-S and 31.2% for EQ-5D-5L.

Conclusions
This study is the first to explore the associations between financial toxicity, EQ-5D-5L, and EQ-HWB outcomes in breast cancer. Our findings provide insight into the cancer burden and its link to health and well-being.
Biogenic synthesis of metal oxide nanoparticles for the elicitation of secondary metabolites in the in vitro propagated plantlets of Rubia cordifolia L.
Authors: Prasad Aparna , Sidhic Jameema , Mohan C. K. Sruthi , Sarbadhikary Paromita , George Satheesh , Narayanankutty Arunaksharan , Tom Renjis T. , George Blassan P. , Abrahamse Heidi 
Published: February 2025

Abstract
In recent decades, nanoparticles (NPs) have become an important focus of research with diverse applications in industries such as food, cosmetics, and medicine. Recent studies have demonstrated that nanomaterials can boost the production of secondary metabolites in plants. In vitro techniques coupled with nanotechnology tools provide an attractive alternative for enhancing the production of targeted dye products (Alizarin and Purpurin) from crops. In this study, biocompatible hexagonal-shaped Zinc oxide nanoparticles and monoclinic-spherical-shaped Copper oxide nanoparticles (CuO NPs) were synthesized from the stem extract of Rubia cordifolia L., with average particle sizes of 17.9 nm and 28.35 nm, respectively. Quantitative phytochemical assessments, HRLC-MS analysis, HPTLC fingerprinting, and antioxidant properties in methanolic extracts of in vitro treated plants with different concentrations of metallic oxide NPs showed variations, in both quality and quantity of secondary metabolites. The treatment of 0.1 mg/L CuO NPs showed the highest level of secondary metabolites including alizarin and purpurin. Notably, concentrations exceeding 10 mg/L transformed these nanoparticles from elicitors to potentially toxic components for the plantlets. The extracts elicited by CuO NPs (0.1 mg/L) exhibited high antioxidant activity due to these metabolic changes. CuO NP treatment provided a useful and efficient in vitro technique to enhance the synthesis of plant based bioactive compounds with potential applications in the pharmaceutical and textile industry.
First Assessment of Freshwater Monitoring Under the Eu National Emission Ceilings Directive: Emerging Issues and Way Forward
Authors: Cesarini Giulia , Fornaroli Riccardo , Boggero Angela , Musazzi Simona , Zaupa Silvia , Dumnicka Elzbieta , Marchetto Aldo , Rogora Michela 
Published: February 2025

Abstract
Air pollution has significantly increased during the Anthropocene, adversely affecting ecosystems and human health. The National Emission Ceilings Directive (NECD, 2016/2284/EU) set targets for reducing emissions and required Member States to establish a national monitoring network to assess ecosystem changes due to air pollution. For freshwaters, the NECD monitoring focused on assessing effects of sulphur and nitrogen deposition and acidification status using chemical parameters and sensitive biological indicators. This paper evaluates the present NECD monitoring scheme and its applicability in Italy, from site selection to initial data collection. High mountain lakes were selected as study sites, because they are free from direct human impacts and sensitive to air pollutant deposition. A two-year survey of chemical and biological components (diatoms and macroinvertebrates) was conducted in eight lakes with the aim to (1) assess the suitability of chemical parameters and biological indices for evaluating air pollutant impacts on sensitive water bodies in Italy, focusing on acidification and nitrogen enrichment, and (2) discuss the current approach's achievements and limitations. Results highlighted the need to develop specific indices for detecting atmospheric pollution impacts on freshwater ecosystems. Beside acidification, other drivers, including nutrients, proved to be important in shaping mountain lakes biological assemblages and affecting their response to pollutant deposition. Our study contributed to a critical assessment of the present freshwater monitoring under the NECD from the Italian perspective, providing indications on future improvement and development of the monitoring scheme itself.
Improving care interactions (and training) in nursing homes with artificial intelligence
Authors: Lefelle Marie , Samy Modeliar Mouny 
Published: February 2025

Abstract
As the population continues to age, nursing homes will increasingly play a key role in caring for dependent individuals. To enhance the well-being of the elderly, it is crucial to focus on the language skills used during care interactions. However, issues such as the taboo surrounding dependency, scandals involving private nursing home management, the pressure for caregiver efficiency, and the variety of care contexts make monitoring these skills challenging. One way to address this is by collecting in situ data, supervised by language researchers and caregivers specialized in elderly care. This is the approach we have followed: the data collected was then analyzed using machine learning models to provide caregivers with crucial insights for improving care outcomes. Our research highlights the importance of specific factors in language-based interactions, especially in varied care situations. Notably, we emphasize the careful use of humor and the impact of caregiver experience on the success of care sessions. Consequently, we advocate for caregiver training that is grounded in real-life practice, focusing on context adaptation, active listening, and dialogue with residents.
Modification of Pure Zinc Surface for Biomedical Applications: The Effect of Oxygen Plasma Immersion Ion Implantation on Tuning the Degradation Rate
Authors: Gambaro S. , Ould Mohamed S. , Beraldo C. H. M. , Paternoster C. , Agbe H. , Lecis N. , Mantovani D. 
Published: February 2025

Abstract
Zinc is a high-potential metal for biodegradable implants. The study of the surface properties, even if at a fundamental level, is of central importance because the surface is the place where electrochemical, physical, and biological interactions take place; this is critical especially for biomedical applications, in which these interactions affect each other. The present work investigates the effect of low-energy oxygen implantation, in the range of − 1 to − 5 kV, for different durations on commercially pure Zn, whose surface had been mechanically polished. The characterization of the as-received and implanted surface was carried out with standard and high-resolution electron microscopy, energy dispersive X-ray spectroscopy, sessile drop contact angle, X-ray photoelectron spectroscopy, and potentiodynamic tests. The plasma-treated surface showed distinct features related to the process parameters, such as the formation of surface waves and oxide agglomerates. The formation of an O-rich layer with specific morphological features was responsible for a slight modification of the corrosion rate, found to be generally lower for longer-time implanted samples being, for instance, ~  78 ± 26 μm year−1 for samples implanted applying − 1 kV for 60 min compared to that of untreated samples, which is ~ 135 ± 9 μm year−1.
A Meta-analytic Review of Platelet-Rich Plasma in Fat Grafting: Enhancing Clinical Outcomes
Authors: Arkoubi Amr Youssef 
Published: February 2025

Abstract
While platelet-rich plasma (PRP) has gained popularity in plastic surgery, the supporting evidence for its use in this field has not been thoroughly evaluated. This meta-analysis investigated the efficacy and safety of PRP combined with fat grafting compared to fat grafting alone, focusing on fat survival rate outcomes. A comprehensive and systematic search of the Cochrane Library, Web of Science, EMBASE, and PubMed databases was conducted for clinical studies on platelet-reconstituted plasma and fat transfer between 2000 and 2024 for this PRISMA-guided meta-analysis. The methodological quality of the included studies was assessed using the Downs and Black measure. Fifteen trials, encompassing 1215 patients, 417 in the autologous fat graft (AFG) group, and 798 in the (PRP) group, were included and evaluated. Patients were monitored from 3 to 12 months after PRP administration, compared to the fat grafting alone group. The PRP + AFG group demonstrated a significantly higher fat survival rate (0.34 [0.33, 0.35], p < 0.00001) and a significantly shorter recovery period (− 2.67 [− 4.95, − 0.40], p = 0.02). Patient satisfaction was also significantly higher in the PRP group (3.81 [2.59, 5.60], p < 0.00001). This research suggests that PRP-enhanced fat transplantation offers advantages over conventional fat grafting alone in terms of fat survival rate and recovery period.
Unequal fields: Political ecology perspective on organic cotton production in Tajikistan
Authors: Zakirova Aksana , Alff Henryk , Schmidt Matthias 
Published: February 2025

Abstract
The paper explores the adoption of organic cotton production by smallholder farmers in Tajikistan’s northern Sughd and southwestern Khatlon regions through the lens of political ecology. The research focuses on the complex interactions among socio-economic, environmental and political variables that influence the decision-making processes of Tajikistani smallholders as they navigate the transition towards adopting organic farming practices. This transition, initiated and guided by the external actors, largely from high-income nations, emphasizes broader power dynamics and asymmetries inherent within the global agricultural system. In addition to illuminating the pivotal role of smallholder farmers in sustainable agriculture and rural development, we ask how power relations, institutional frameworks, and market dynamics impacts the adoption of organic cotton by smallholders in Tajikistan, and the implications this has for local communities. By exploring these dimensions, we emphasize the need for supportive policies and the development of inclusive market mechanisms. This study acknowledges the vulnerability of smallholders to the volatility of the global organic cotton markets, influenced by external shocks such as pandemics, wars, and natural hazards. Considering the absence of domestic markets for organic produce in Tajikistan, we stress the reliance of smallholders on turbulent external markets, highlighting the urgent need for resilient and diversified market linkages to safeguard their livelihoods.
Impact of climate change and land use/cover change on water yield in the Liaohe River Basin, Northeast China
Authors: Lyu Leting , Jiang Ruifeng , Zheng Defeng , Liang Liheng 
Published: February 2025

Abstract
The Liaohe River Basin (LRB) in Northeast China, a critical agricultural and industrial zone, has faced escalating water resource pressures in recent decades due to rapid urbanization, intensified land use changes, and climate variability. Understanding the spatiotemporal dynamics of water yield and its driving factors is essential for sustainable water resource management in this ecologically sensitive region. This study employed the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model to quantify the spatiotemporal patterns of water yield in the LRB (dividing into six sub-basins from east to west: East Liaohe River Basin (ELRB), Taizi River Basin (TRB), Middle Liaohe River Basin (MLRB), West Liaohe River Basin (WLRB), Xinkai River Basin (XRB), and Wulijimuren River Basin (WRB)) from 1993 to 2022, with a focus on the impacts of climate change and land use cover change (LUCC). Results revealed that the LRB had an average annual precipitation of 483.15 mm, with an average annual water yield of 247.54 mm, both showing significant upward trend over the 30-a period. Spatially, water yield demonstrated significant heterogeneity, with higher values in southeastern sub-basins and lower values in northwestern sub-basins. The TRB exhibited the highest water yield due to abundant precipitation and favorable topography, while the WRB recorded the lowest water yield owing to arid conditions and sparse vegetation. Precipitation played a significant role in shaping the annual fluctuations and total volume of water yield, with its variability exerting substantially greater impacts than actual evapotranspiration (AET) and LUCC. However, LUCC, particularly cultivated land expansion and grassland reduction, significantly reshaped the spatial distribution of water yield by modifying surface runoff and infiltration patterns. This study provides critical insights into the spatiotemporal dynamics of water yield in the LRB, emphasizing the synergistic effects of climate change and land use change, which are pivotal for optimizing water resource management and advancing regional ecological conservation.
Comparing the osteogenic effects of sputtered titanium- and strontium titanate (STO)-modified polyetheretherketone
Authors: Ikuta Masato , Harumningtyas Anjar Anggraini , Ito Tomoko , Fujita Kenta , Kitahara Takayuki , Bun Masayuki , Furuichi Takuya , Hirai Hiromasa , Ukon Yuichiro , Tateiwa Daisuke , Kanie Yuya , Furuya Masayuki , Fujimori Takahito , Okada Seiji , Hamaguchi Satoshi , Kaito Takashi 
Published: February 2025

Abstract
Polyetheretherketone (PEEK) is widely used as an interbody cage due to its elastic modulus closely resembles that of human bone. However, its biological inertness is considered a major weakness, as it cannot directly bond with bone (lack of osseointegration capacity). Surface modification can impart bioactivity to PEEK while maintaining its mechanical properties. In this study, the surface of PEEK was modified with titanium or strontium titanate thin films formed by magnetron sputtering deposition. We evaluated the bone formation activity of strontium titanate-modified PEEK (PEEK-STO) by comparing three groups: unmodified PEEK (PEEK), titanium-modified PEEK (PEEK-Ti), and strontium titanate-modified PEEK (PEEK-STO). Osteogenic differentiation of cells, assessed by ALP activity, bone-related gene expression, and mineralization ability, demonstrated that PEEK-STO has the highest osteogenic activity. Furthermore, the evaluation of mineral deposition by non-cellular mechanisms using simulated body fluid showed that PEEK-Ti and PEEK-STO have higher calcium phosphate deposition capacity than PEEK. In vivo implantation of the materials into the rat femur demonstrated that bone-to-implant contact ratio (BIC%) and bone area ratio (BA%) in the proximity zone from the implant were significantly larger in PEEK-STO compared to PEEK-Ti and PEEK at 4 weeks post-surgery. This study demonstrates that surface modification of PEEK with strontium titanate through magnetron sputtering is an attractive option for solving the problems of PEEK’s biological inertness while making the most of the advantages of PEEK as a spinal fusion device.
Analysis of the spatial heterogeneity and influencing factors of music training institutions: a case study of Beijing, Shanghai, Guangzhou, and Shenzhen
Authors: Zhao Jun , Cui Xiangwen , Wang Shaohua , Liu Wenwen , Liu Jiewen , Liu Chang , Zhong Yang , Zhang Zhidong 
Published: February 2025

Abstract
In contemporary society, music art plays a pivotal role in enhancing spiritual quality-of-life and optimizing talent cultivation models. The spatial distribution of music educational resources undoubtedly plays a promotional role in enhancing the quality of music education. However, existing research has not conducted specialized and in-depth studies on this topic. This study uses a geographic information system (GIS) and classical geographical research methods such as the nearest neighbor index, kernel density analysis, and geographic detectors to analyze the spatial distribution and influencing factors of music training institutions in Beijing, Shanghai, Guangzhou, and Shenzhen. The results indicate that the distribution of these institutions is obviously clustered, with a "northeast‒southwest" trend in Beijing and Shenzhen and a "northwest‒southeast" trend in Shanghai and Guangzhou. Among the categories of urban facilities, which encompass sports, leisure, shopping, and dining, sports venues exert the most substantial influence on the spatial distribution characteristics of music training institutions. The location of music training institutions should be closely integrated with the spatial distribution of urban facilities. This study provides theoretical foundations and practical guidance for policy-makers in the refined adjustment of urban layouts, the rational allocation of artistic educational resources, and the promotion of cultural industry development.
Exploring cooperative governance mechanisms for the ecological security of marine ranching: A differential game approach
Authors: Leng Jie 
Published: February 2025

Abstract
Owing to the increasingly critical ecological security challenges of marine ranching, the government and marine ranching enterprises must collaborate effectively to address this issue. This study employs differential game theory to explore collaborative strategies for maintaining marine ranching ecological security. It considers the influence of marine environmental disaster factors and the effect of enterprises’ ecological security investment through advertising. Three collaborative modes are analyzed: No-cost-sharing, cost-sharing, and full collaborative cooperation. Results show that the increased intensity of marine environmental disasters reduces the optimal ecological security effort by the government and enterprises. Government subsidy initiatives can achieve Pareto improvements in total returns for the government, enterprises, and the system as a whole. In the fully cooperative mode, the collective income of the government, enterprises, and system achieves its highest value, reaching Pareto optimality. Introducing an income distribution mechanism can effectively sustain cooperative engagement between the government and enterprises.