bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Flash Cards Media in Reducing Speech Delay Symptoms in Children (A Case Study in BA Aisyiyah Prembun, Tambak District, Banyumas Regency)
Authors: Sajawandi Labib , Kurniati Yulia , Muslim Aji Heru , Huda Tesa Nurul 
Published: November 2023

The background of this study is to describe the process of using flashcard media to reduce the symptoms of speech delay in children, implemented by class teachers in BA Aisyiyah Prembun. It was found to have a significant impact on children's speech development. This study adopted a qualitative method with a case study approach. The qualitative method is used because this study aims to discuss the factors influencing children's speech delay and how the flashcards enhance the speaking skills of children with speech delays in BA Aisyiyah Prembun. Using the qualitative research method for this is more straightforward and more effective. Data collection methods in this research included observation, interviews, and documentation. The findings indicated improved speech development in the subjects after the class teacher continuously used flash cards five times a week. Initially, the subjects had difficulty speaking. However, by the 6th month, there was a significant improvement in the child's speech. They can speak fluently and clearly after the intervention using flash cards.
Teaching Speaking Using Youtube to Eleventh Grade Students in SMK PGRI 4 Kediri
Authors: Nurfaid Roni 
Published: November 2023

The ability of English speaking skills at SMK PGRI 4 Kediri can still be said to be low, they need to learn a lot more about speaking, the researcher wants to apply the learning media, namely YouTube to students' speaking skills, whether there will be changes in their skills later. Therefore, researchers wanted to do this research aims to know there are any significant differences or not after give the learning media, namely YouTube in students’ speaking skills in Eleventh Grade SMK PGRI 4 Kediri. This research questions are: 1) How are students' speaking skills before being given YouTube videos?, and 2) How significance is the effect after being taught using YouTube? The subject of this research is eleventh grade TKRO 2 in SMK PGRI 4 Kediri which consist 25 students. This research used a quantitative method and used a pretest and posttest data collection. Then, the researcher analyzed the data by paired t-test in SPSS. The result of research showed significant increasing in the effect of YouTube. The T-Test had been found 25.067>-1.350, so tcount > ttable, then the score of pretest and posttest any significant increase, namely from 41,60 to 65,60. So the researcher concluded if YouTube is worth it to apply in students learning in speaking.
Implementasi Model Pembelajaran Predict-Observe-Explain (POE) untuk Meningkatkan Keterampilan Proses Sains Dasar Siswa Kelas 8A di SMPN 2 Jatilawang
Authors: Rabany Putri Sabiq Shidiqia , Nofiana Mufida 
Published: November 2023

Penelitian ini bertujuan untuk meningkatkan keterampilan proses sains dasar siswa kelas 8A di SMPN 2 Jatilawang melalui model Predict-Observe- Explain (POE) dan mengetahui peningkatan aspek KPS setelah diterapkan model POE. Penelitian ini merupakan penelitian tindakan kelas yang telah dilaksanakan dalam 2 siklus. Subyek penelitian adalah kelas 8A tahun ajaran 2022/2023 berjumlah 36 siswa. Instrumen penelitian berupa lembar observasi, test, angket dan wawancara. Pengambilan data menggunakan triangulasi data. Kesimpulan rata-rata nilai KPS pra siklus 43,09% dengan kategori kurang sekali dan mengalami peningkatan pada siklus I sebesar 50,36% kategori kurang sekali dan meningkat pada siklus II 63,65% dengan kategori cukup. Rata-rata respon siswa 77,35% dengan kategori positif. Aspek KPS yang meningkat yaitu mengamati, meramalkan, mengkomunikasikan. Hal ini menunjukkan bahwa model POE dapat meningkatkan keterampilan proses sains dasar siswa dengan peningkatan aspek yang optimal pada aspek mengamati, meramalkan dan mengkomunikasikan.
PERANAN KELOMPOK TANI DALAM PENINGKATAN PRODUKTIVITAS PADI SAWAH DI DESA WAIMITAL KECAMATAN KAIRATU KABUPATEN SERAM BAGIAN BARAT
Authors: Souhaly Neva , Tahitu Meilvis E , Damanik Inta P. N. 
Published: November 2023

Penelitian ini bertujuan untuk menganalisis peran kelompok tani terhadap peningkatan produktivitas padi sawah di Desa Waimital. Peran kelompok tani dimaksudkan sebagai wadah belajar dan berorganisasi, wadah kerja sama, dan sebagai unit produksi. Data yang dikumpulkan dalam penelitian ini merupakan data primer (wawancara dengan responden) dan data sekunder (data yang dikumpulkan melalui instansi dan literatur). Data yang telah terkumpul ditabulasi dan dianalisis secara deskriptif kualitatif dengan dukungan analisis Chi Square. Hasil penelitian menunjukkan bahwa kelompok tani telah menjalankan peran sebagai wadah belajar dan berorganisasi, wadah kerja sama, serta unit produksi usahatani dalam kategori baik. Ditemukan pula bahwa ada hubungan antara ketiga peran kelompok tani tersebut dengan peningkatan produktivitas usahatani.
Noninvasive µ-XRF Analysis of Ancient Silver Object
Authors: Oudbashi Omid , Carò Federico , de Lapérouse Jean-Francois 
Published: November 2023

Abstract
This case study details the noninvasive analysis of an 5000-year-old silver figurine from Iran, now in the collection of The Metropolitan Museum of Art. The The object of this study, a figure of a kneeling bull clothed in a robe with a stepped linear pattern and holding up a spouted vessel, is composed of 15 pieces of worked silver joined together with silver solder. The aim of the study is to apply noninvasive micro-xray fluorescence spectroscopy (μ-XRF) analysis to characterize the silver alloy compositions and compare the new data with previously obtained results from invasive chemical analyses of samples performed by thermal neutron activation.
Exploring Nitinol’s Billion Cycle Fatigue Life
Authors: Berg Brian T. , Aycock Kenneth I. , Falk Wayne M. , Weaver Jason D. 
Published: November 2023

Abstract
This article reports on a multifaceted testing and modeling approach to investigate the fatigue life of medical grade Nitinol to one billion cycles. The goal of a the research is to understand the mechanism of Nitinol ultra-high cycle fatigue and to eventually be able to predict when fracture will occur.
Fluorescence quenching-based immunological probe for ticagrelor monitoring
Authors: Zhang Shengshuo , Cheng Yueqing , Gao Yujie , Zou Yujie , Xiao Weiling , Li Tianyi , Li Mei , Yu Bowen , Dong Jinhua 
Published: November 2023

Introduction: Ticagrelor is extensively utilized for the treatment of acute coronary syndromes (ACS), but its platelet aggregation inhibitory effects can potentially result in tissue bleeding, posing a serious risk to patients’ lives.Methods: In this study, we developed highly sensitive full length anti-ticagrelor Quenchbodies (Q-bodies) for fast monitoring of ticagrelor both in solution and serum for the first time. Ticagrelor coupled with N- hydroxysuccinimide (Ticagrelor-NHS) ester was also designed and synthesized for interaction and biological activity detection.Results: Both ATTO-labeled MEDI2452 (2452A) Q-body and TAMRA-labeled IgG 152 (152T) Q-body demonstrated efficient detection of ticagrelor and its active metabolite (TAM). The 2452A Q-body exhibited a broader detection range, while the 152T Q-body displayed a lower limit of detection (LOD). Under physiological conditions (Ticagrelor:TAM, 3:1), the concentration of ticagrelor was further measured, yielding LOD values of 4.65 pg/mL and 2.75 pg/mL for the two Q-bodies, with half-maximal effect concentrations of 8.15 ng/mL and 3.0 ng/mL, respectively.Discussion: Compared with traditional liquid chromatography-mass spectrometry (LC-MS) methods, anti-ticagrelor Q-bodies have higher sensitivity and detection speed. It enabled the completion of analysis within 3 min, facilitating rapid preoperative detection of blood drug concentration in ACS to determine the feasibility of surgery and mitigate the risk of intraoperative and postoperative hemorrhage. The swift detection of ticagrelor holds promise for enhancing individualized drug administration, preventing adverse reactions, and providing preoperative guidance.
Assessing health science students’ gaming experience: a cross-sectional study
Authors: Rodríguez-Roca Beatriz , Calatayud Estela , Gomez-Soria Isabel , Marcén-Román Yolanda , Cuenca-Zaldivar Juan Nicolas , Andrade-Gómez Elena , Subirón-Valera Ana Belén 
Published: November 2023

BackgroundDigital gamification applied to university students enrolled in health-related degrees is considered an innovative and beneficial tool that complements traditional teaching.ObjectivesTo analyze the enjoyment experience obtained by university students in the Faculty of Health Sciences and to know the gender differences after participating in a digital game.DesignCross-sectional descriptive study.ParticipantsA total of 156 university students from the Faculty of Health Sciences, University of Zaragoza.MethodsThe activity of a digital game took place in the academic year 2021–2022 and was carried out as a teaching innovation project with the final approval of the University of Zaragoza. The tools used were the Spanish version of the Gameful Experience Scale and a self-administered questionnaire on satisfaction and suitability reported by the activity.ResultsA total of 156 students participated with an age of 21.2 ± 6.2 years. The highest score is the enjoyment dimension (4 ± 0.7), and the lowest score is the negative affect dimension (1.5 ± 0.9). Cronbach’s alpha for the whole Gameful Experience Scale was 0.95. There were significant differences in three dimensions of the Gameful Experience Scale: male students had more enjoyment than female students (p = 0.05), enjoyed a greater sense of domination (p = 0.01), and had fewer negative effects (p = 0.0). In the highest corresponding positions it was used for other topics such as learning (m 4.4; SD 0.5), motivation to learn (m 4.1; SD 0.8) or helping memorize concepts (m 4.4).4; SD 0.5).ConclusionGender influences student satisfaction after carrying out a gamification activity, especially after a digital game. The dimensions in which gender differences were found were fun, absence of negative effects, and dominance.
Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China
Authors: Ren Xue-Wen , Chen Kang , Wu Jue , Yang Zhang-Lin , Ji Tao , Zhang Qing-Hong 
Published: November 2023

PurposeWe sought to identify distinct risk factors for hyperuricemia in native Tibetan and immigrant Han populations in Tibet, China.MethodsThree cohorts of male participants aged between 20 and 40 years were enrolled in this study. Biochemical parameters including serum uric acid (UA), fasting plasma glucose, insulin, lactate dehydrogenase (LDH), thyroxin, blood cell count, aminotransferase, and lipid profiles were analyzed. The association of risk factors with UA levels was evaluated using a multivariable line regression model. The effect of UA level on the biochemical parameters between the Hans and Tibetans was evaluated by two-way ANOVA.ResultsThe prevalence of hyperuricemia (≥420 μmol/L) was 24.8% (62/250) in the Hans, similar to 23.8% (29/136) in the Tibetans. In the regression analysis, the risk factors that were significantly associated with UA in Hans did not apply to Tibetans. Tibetans had higher fasting insulin (P&lt;0.05) and LDH (P&lt;0.01) levels, in contrast with lower levels of triglycerides (P&lt;0.05), total cholesterol (P&lt;0.01), and low-density lipoprotein-cholesterol (P&lt;0.01) than Hans in normal UA populations. Biochemistry analysis revealed lower albumin levels (P&lt;0.001) and higher levels of all aminotransaminase and especially alkaline phosphatase (P&lt;0.01) in Tibetans than in Hans in both populations. Compared with Hans, Tibetans had lower serum levels of urea, creatinine, and electrolytes in the normal UA population, which were further exacerbated in the high UA population. Tibetans had comparable white blood cell counts as Hans in both normal and high UA populations. In contrast, the red blood cell count and hemoglobin concentration were much lower in Tibetans than in Hans under high UA conditions.ConclusionsThe distinctive biochemistry between Tibetans and Hans may underlie the different etiologies of hyperuricemia in Tibet, China.
Associations between body composition profile and hypertension in different fatty liver phenotypes
Authors: Huang Xiaoyin , Zeng Yuchen , Ma Mingyang , Xiang Liangguang , Liu Qingdan , Xiao Ling , Feng Ruimei , Li Wanxin , Zhang Xiaoling , Lin Moufeng , Hu Zhijian , Zhao Hongwei , Du Shanshan , Ye Weimin 
Published: November 2023

BackgroundIt is currently unclear whether and how the association between body composition and hypertension varies based on the presence and severity of fatty liver disease (FLD).MethodsFLD was diagnosed using ultrasonography among 6,358 participants. The association between body composition and hypertension was analyzed separately in the whole population, as well as in subgroups of non-FLD, mild FLD, and moderate/severe FLD populations, respectively. The mediation effect of FLD in their association was explored.ResultsFat-related anthropometric measurements and lipid metabolism indicators were positively associated with hypertension in both the whole population and the non-FLD subgroup. The strength of this association was slightly reduced in the mild FLD subgroup. Notably, only waist-to-hip ratio and waist-to-height ratio showed significant associations with hypertension in the moderate/severe FLD subgroup. Furthermore, FLD accounted for 17.26% to 38.90% of the association between multiple body composition indicators and the risk of hypertension.ConclusionsThe association between body composition and hypertension becomes gradually weaker as FLD becomes more severe. FLD plays a significant mediating role in their association.
Association between the neutrophil-to-lymphocyte ratio and cognitive impairment: a meta-analysis of observational studies
Authors: Hung Kuo-Chuan , Liu Chien-Cheng , Wu Jheng-Yan , Ho Chun-Ning , Lin Ming-Chung , Hsing Chung-Hsi , Chen I-Wen 
Published: November 2023

BackgroundSystemic inflammation is one of the underlying mechanisms of cognitive impairment. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a systemic inflammation indicator. This meta-analysis aimed to evaluate the association between high NLR and cognitive impairment (CI) risk.MethodA comprehensive systematic search was conducted to identify eligible studies published until May 30, 2023. The reference group comprised patients with the lowest NLR level, whereas the exposure group comprised those with the highest NLR level. The main outcome was to examine the relationship between NLR and CI risk. The secondary outcome included the association between patient characteristics or comorbidities and CI risk.ResultsThis meta-analysis included 11 studies published between 2018 and 2023, involving 10,357 patients. Patients with CI had a higher NLR than those without (mean difference=0.35, 95% confidence interval [CI]: 0.26–0.44, p &lt; 00001, I2 = 86%). Consistently, pooled results revealed an association between high NLR and CI risk (odds ratio [OR]=2.53, 95% CI:1.67–3.82, p&lt;0.0001, I2 = 84%). Furthermore, aging (mean difference =4.31 years, 95% CI:2.83–5.8, p &lt; 0.00001, I2 = 92%), diabetes (OR=1.59, 95% CI:1.35–1.88, p &lt; 0.00001, I2 = 66%), and hypertension (OR=1.36, 95% CI:1.19–1.57, p &lt; 0.00001, I2 = 0%) were significant risk factors for CI. However, no significant associations were observed between CI and male gender (OR = 0.84, 95% CI:0.64–1.11, p = 0.22, I2 = 81%), body mass index (mean = −0.32 kg/m2, 95% CI: −0.82, 0.18, p = 0.2, I2 = 82%), alcohol consumption (OR = 1.11, 95% CI:0.95−1.3, p = 1.35, I2 = 0%), and smoking (OR = 0.99, 95% CI:0.87–1.13, p = 0.86, I2 = 0%). Meta-regression found that diabetes and hypertension, but not age, significantly moderated the association between NLR and CI.ConclusionThis meta-analysis showed a significant association between high NLR and increased CI risk. Moreover, meta-regression identified diabetes and hypertension, but not age, as significant moderating factors in the relationship between NLR and CI. To validate and strengthen these findings, further large-scale studies are required.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023430384, identifier CRD42023430384.
Techno-economic and environmental evaluation of the production of biodiesel from rice-straw in China
Authors: Hu Yixuan , Chen Jiajun , Tian Hong , Hu Zhangmao 
Published: November 2023

Rice straw (RS) is the residue obtained during the rice processing process, and is recognized as one of the most abundant biomass resources in the world. Approximately 800 million to 1 billion tons of rice straw are produced globally every year, and most of them are considered general waste and typically end up in landfills or incineration. This approach wastes resources and can also lead to environmental pollution. In the current study, the RS was used as the source of biodiesel production and a comprehensive process model of the RS valorization process was developed to evaluate the energy flow, production efficiency, production costs, and greenhouse gas emissions in Hunan Province, China. The evaluation results showed that the energy efficiency of biodiesel production from rice straw and the overall energy efficiency of the rice straw valorization process are reported as 52.1% and 56.1%, respectively. The minimum selling price of biodiesel, which is CNY 3.03/kg, is considerably lower than the current market prices for similar products in China. The largest proportion of the production cost of biodiesel is the cost of natural gas, followed by utilities, capital, transportation, plant maintenance and overheads, consumables, labor, and waste disposal. For the current RS valorization plant with a 5000 kg/h RS feed rate, the investment payback times are 8.9 yr and 7.1 yr when the biodiesel is sold at the lowest (CNY 4/kg) and highest (CNY 4.6/kg) market price, respectively. Environmental analysis shows that the greenhouse gas emissions intensity of biodiesel production is 75.8 g CO2eq/MJ, which is only about 52% of traditional fossil diesel and indicating that biodiesel is an environmentally friendly energy source.
Predicting the response of three common subtropical tree species in China to climate change
Authors: Jin Songheng , Chi Yi , Li Xueqin , Shu Pengzhou , Zhu Mengxun , Yuan Zheng , Liu Yang , Chen Wenjing , Han Yini 
Published: November 2023

IntroductionClimate is crucial factor influencing species distribution, and with global climate change, the potential geographic distribution of species will also alter. In this study, three subtropical tree species (Cunninghamia lanceolata, Pinus taiwanensis, and Quercus glauca) of great ecological values were selected as research objects.MethodsWe applied a maximum entropy (MaxEnt) to predict their potential distributions under different climate scenarios in both present and future conditions based on 37 environmental factors. Jackknife test was used in key factors affecting species distribution. In addition, we explored the key environmental variables that affect their distributions and revealed the evolutionary patterns and migration trends of these tree species under future climate.ResultsThe main findings are as follows: (1) Winter temperature, winter precipitation, and annual temperature range are identified as the key environmental variables affecting the potential geographic distribution of the three tree species; moreover, precipitation-related factors have a greater impact than temperature-related factors; (2) Currently suitable habitats for these three tree species are primarily located in subtropical China with decreasing suitability from south to north; (3) Under future climate conditions, the area of potentially suitable habitat for C. lanceolata continues to expand, while P. taiwanensis and Q. glauca tend to experience a reduction due to increasing greenhouse gas emissions over time; and (4) The centroid of suitable habitat for C. lanceolata shifts northward under future climate change, while the centroid of P. taiwanensis and Q. glauca move southward along with shrinking suitable habitat area.DiscussionOur predictions highlight a high risk of habitat loss of Q. glauca under climate change, recommending management and conservation references for these three commonly used afforestation species under current and future climate change scenarios in China.
Appraising the causal relationship between thyroid function and rheumatoid arthritis: a two-sample bidirectional Mendelian randomization study
Authors: Gu Peng , Pu Bin , Ma YangCheng , Yue Dan , Xin Qiao , Li HaiShan , Liu Teng , Zheng XiaoHui , Ouyang ChongZhi 
Published: November 2023

BackgroundHypothyroidism and hyperthyroidism are observationally associated with rheumatoid arthritis (RA), but causality is unclear. To evaluate the causal relationship between thyroid function and RA, we conducted a two-Sample bidirectional Mendelian Randomization (MR) study.MethodsSingle nucleotide polymorphisms associated with six phenotypes were selected from the FinnGen biobank database, The ThyroidOmics Consortium database, and the IEU Open GWAS database. For the forward MR analysis, we selected hypothyroidism (N=213,390), Graves’ disease (GD) (N=199,034), other types of hyperthyroidism (N=190,799), free thyroxine (FT4, N=49,269), and thyroid-stimulating hormone (TSH, N=54,288) as the five related thyroid function phenotypes for exposure, with RA (N=58,284) as the outcome. Reverse MR analysis selected RA as the exposure and five phenotypes of thyroid function as the outcome. The Inverse variance weighting (IVW) method was used as the primary analysis method, supplemented by weighted median (WM) and MR-Egger methods. Cochran’s Q test, MR-PRESSO, MR-Egger regression methods, and leave-one-out analysis were employed to assess sensitivity and pleiotropy.ResultsForward MR evidence indicates that genetic susceptibility to hypothyroidism is associated with an increased risk of RA (ORIvw=1.758, P=7.61×10-5). Reverse MR evidence suggests that genetic susceptibility to RA is associated with an increased risk of hypothyroidism (ORIvw=1.274, P=3.88×10-20), GD (ORIvw=1.269, P=8.15×10-05), and other types of hyperthyroidism (ORIvw=1.141, P=1.80×10-03). There is no evidence to support a forward or reverse causal relationship between genetic susceptibility to RA and FT4, TSH.ConclusionOur results provide genetic evidence supporting bidirectional causal relationships between thyroid function and RA. These findings inform preventive strategies and interventions targeting RA and thyroid dysfunction.