bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Gaya Belajar terhadap Prestasi Belajar pada Peserta Didik
Authors: Budi Eko Setia 
Published: January 2024

Abstract. This research aims to find out the influence of learning styles on the learning achievements of MTs.Darul Karomah Singosari students. The method used in this study is exposed facto. The study's population of 50 students was selected using simple random sampling techniques. Data collection is carried out by disseminating learning style questionnaires and documenting students' raport within 1 semester. This study uses quantitative data analysis techniques, normality and homogeneity tests, as well as anova tests. Hypothetical testing uses a single-track anova test with data processing using SPSS 16.0 for windows. The results showed that learning styles had no significant influence or contribute to the students' learning achievements. This can be seen from the result of a significance score of 0.990 so that the value of the anova test significance of the learner is more than 0.05.
Keywords: Learning Style, Achievement Learning, Learners

Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh gaya belajar terhadap prestasi belajar peserta didik MTs.Darul Karomah Singosari. Metode yang digunakan dalam penelitian ini adalah ekspos fakto. Populasi penelitian ini berjumlah 50 peserta didik yang dipilih menggunakan teknik simple random sampling. Pengumpulan data dilaksanakan dengan menyebar angket gaya belajar dan melakukan dokumentasi raport peserta didik dalam kurun waktu 1 semester. Penelitian ini menggunakan teknik analisis data kuantitatif, uji normalitas dan homogenitas, serta uji anova. Pengujian hipotesis menggunakan uji anova satu jalur dengan pengolahan data menggunakan SPSS 16.0 for windows. Hasil penelitian menunjukkan bahwa gaya belajar tidak memiliki pengaruh atau sumbangan yang signifikan terhadap prestasi belajar peserta didik. Hal ini dapat dilihat dari hasil nilai signifikansi sebesar 0,990 sehingga nilai signifikansi uji anova peserta didik lebih dari 0,05.
Kata kunci: gaya belajar, prestasi belajar, peserta didik
Literature Review: Keefektifan Metode Blended Learning untuk Meningkatkan Motivasi Belajar Siswa
Authors: Herlina Herlina 
Published: January 2024

Abstract. The purpose of this literature review article is to see how the effectiveness of a blended learning method in increasing student motivation. The method used in searching for articles using a database in the form of google search, google schoolar and DOAJ with the keywords blended learning, learning motivation, and students. The results of the data search used the keywords blended learning, learning motivation, and students, and collected 11 articles in full text form and were published in the last ten years. The result of this literature review is that the use of the blended learning method is effective in increasing students' learning motivation.
Keywords: Blended Learning, Learning Motivation, Student

Abstrak. Tujuan dari artikel literature review ini adalah ingin melihat bagaimana keefektifan sebuah metode pembelajaran blended learning dalam meningkatkan motivasi belajar para siswa. Metode yang dilakukan dalam pencarian artikel menggunakan database berupa google search, google schoolar dan DOAJ dengan keyword blended learning, motivasi belajar, dan siswa. Hasil pencarian data menggunakan keyword blended learning, motivasi belajar, dan siswa, dan didapatkan sebanyak 11 artikel dengan bentuk fulltext serta merupakan terbitan dalam sepuluh tahun terakhir. Hasil dari literature review ini adalah bahwa penggunaan metode blended learning efektif untuk meningkatkan motivasi belajar para siswa.
Kata kunci: Blended Learning, Motivasi Belajar, Siswa
Peranan Tenaga Pendidik Untuk Mencapai Implementasi Pendidikan Yang Cerdas Dan Berakter
Authors: Windasari Aulia , Hariyadi Bagus , Firman Radiatama , Alvinita Nurlaely 
Published: January 2024

Abstract. Intelligent and character education is carried out by educating and accompanied by a learning process that deepens and shapes the character of students with the hope that as a result, students with personalities who have strong characters and intellectual principles are realized. The results of this education cannot be separated from the participation and contribution of educators who have quality human resources, which are expected to be able to direct and be able to become role models in the scope of intelligent and characterized education. In this article, we discuss several analytical data materials about research related to the title of our article, which are then concluded to become an article that focuses on the information we need. The embodiment of the education effort is a learning process that must be conceptualized to design and be able to shape the character of students' intelligence which involves the important role of educators who should be able to convey and be able to practice it as an embodiment and or model by students.Keywords: Intelligent character, education

Abstrak. Pendidikan yang cerdas dan berkarakter dilakukan dengan mendidik dan di sertai dengan proses pembelajaran yang memperdalam dan membentuk karakter siswa dengan harapan hasilnya terwujudlah siswa dengan pribadi yang memiliki karakter kuat dan berprinsip intelektual. Hasil pendidikan tersebut tentunya tak lepas dari keikutsertaan dan andil dari para tenaga pendidik yang memiliki SDM yang berkualitas, yang mana para tenaga pendidik di harapkan mampu mengarahkan dan turut bisa menjadi percontohan dalam ruang lingkup penididikan yang cerdas dan berkarakter tersebut. Dalam artikel ini merupakan bahasan atas beberapa bahan data analisa tentang penelitian yang terkait dengan judul artikel kami, yang kemudian ditarik kesimpulan hingga menjadi suatu artikel yang fokus terhadap informasi yang kami perlukan. Perwujudan dari usaha Pendidikan adalah dengan proses pembelajaran yang diharus dikonsep untuk merancang dan dapat membentuk kecerdasan siswa yang berkarakter yang mana didalamnya melibatkan peran penting para tenaga pendidik yang seharusnya mampu menyampaikan sekaligus mampu mempraktikkannya sebagai perwujudan dan atau percontohan oleh siswa.Kata kunci: Pendidikan, Karakter, Cerdas
Peran Lingkungan Pendidikan dalam Implementasi Pendidikan Karakter
Authors: Kasandra Adelina , Hendrawan Frandika Eggi , Amisar Sendika Romzi Fallah , Abdila Yeyiko Eyo 
Published: January 2024

Abstract. The purpose of this article is to discuss the role of the educational environment in character education. The analysis method used is an effectual causal analysis model by reviewing rational relationships, which analyzes the causal relationship between the educational environment in character education and sources from the review literature. The results of this discussion show that the environment has a great influence on character education. The conclusion of this article is that the implementation of character education needs to be supported by a good educational environment.Keywords: environment, learning, Character education

Abstrak. Tujuan artikel ini ialah membahas mengenai peran lingkungan pendidikan dalam Pendidikan karakter. Metode analisis yang dipakai adalah model analisis causal efektual degan meninjau hubungan rasional, yang menganalisa hubungan sebab akibat antara lingkungan Pendidikan pada Pendidikan karakter dengan sumber dari literatur review. Hasil pembahasan ini memperlihatkan bahwasanya lingkungan memberikan pengaruh besar dalam Pendidikan karakter. Kesimpulan dari artikel ini yakni untuk penyelenggaraan Pendidikan karakter perlu ditopang oleh lingkungan Pendidikan yang baik.Kata kunci: lingkungan, pembelajaran, Pendidikan karakter
Aydın’ın İncirliova ve Muğla’nın Yatağan İlçelerinde Kaya Yüzeyine Yapılmış Bizans Dönemine Ait Bir Grup Duvar Resmi
Authors: ÖZYURT ÖZCAN Hatice 
Published: January 2024

Aydın’ın İncirliova ilçesine bağlı Dereağzı köyünün yukarısında Ballıkaya ve Muğla İline bağlı Yatağan ilçesinin Yava köyü sınırları içinde kaya yüzeyine yapılmış dört resimli yüzey tespit edilmiştir. Aydın, Ballıkaya’da oldukça sarp bir alanda bulunan mağaranın girişinin sağ tarafında, sıvalı yüzeyinin üzeri mavimsi-gri bir fondan oluşan panonun içerisine tek figür olarak cepheden ve ayakta Başmelek Mikhail resmedilmiştir. Melek bir tunik üzerine, önü işlemeli bir zırh giymiştir. İki yana yayılmış açık kanatları yere kadar uzanan melek, bir eliyle omzuna dayanan kılıcı, diğeriyle kını aşağıya doğru tutmaktadır. Yatağan’da tespit edilen resimlerin ilki halk arasında Resimli Kaya olarak anılan anıtsal kaya kütlesinin güneybatısında yer almaktadır. Sıvasız yüzeye yapılmış olan resimler, doğu-batı doğrultusunda uzanan iki şerit üzerinde yer almaktadır. Üst şeritte tanımlanabilen ilk sahne Yahuda’nın ihanetidir. Tasvirin orta bölümünde ayakta, birinin gövdesi cepheden, diğerininki yandan resmedilmiş iki figür yer almaktadır. Soldaki İsa’yı, sağdaki Yahuda’yı temsil eden bu figürlerin birbirine yaslanmış başları cephedendir. Tasvirin devamına İsa’nın Çarmıha Gerilmesi resmedilmiştir. Kompozisyonun orta kısmında, çarmıhta İsa, Meryem ve Yahya yer almaktadır. Alt şeritte içinde büst formunda aziz, piskopos ya da kilise babalarına ait portelerin resmedildiği altı madalyan yer alır. Yatağandaki üçüncü resim, Resimli Kaya Kütlesinin kuzeyinde, taş bloklarının oluşturduğu Rozetli Mağara olarak adlandırdığımız küçük bir mekândadır. Sıva üzerine yapılmış resimlerde figüre yer verilmemiştir. Mekân içinde doğal yolla oluşmuş kubbemsi formun etrafı siyah, ince bir çizgiyle çerçevelenerek içerisi açık yeşil renkli kalın dairesel bir bordürle sınırlandırılmıştır. Dairesel çerçevenin sol dış köşesinin alt bölümünde, uzun yeşil yapraklı bir lale motifi yer almaktadır. Yatağan’daki dördüncü resimli yüzey, Resimli kayanın kuzeybatısında, Nişli Kaya olarak adlandırdığımız kaya kütlesinin batı yüzünde bulunan derin bir nişin içindedir. Nişin içi sıvanarak, tek sahneli bir resimle bezenmiştir. Sahnenin ortasına, Meryem ve kucağında çocuk İsa resmedilmiştir. Rozetli Mağara haricindeki resimlerin, üslupsal ve ikonokrafik özelliklerinden hareketle Orta Bizans dönemi içinde yapıldığı Resimli Kaya’nın 1. grup resimlerinin 2. evresinin de yine bu dönem içerisinde yenilendiği anlaşılmaktadır. Rozetli kayada yer alan resimlerin ise, üslup ve motif seçimleri İkonoklazma dönemine işaret etmektedir.
Coronaviruses in rodents and insectivores in Altai Republic
Authors: Yashina L. N. , Abramov S. A. , Smetannikova N. A. , Malyshev B. S. , Krivopalov A. V. , Dupal T. A. 
Published: January 2024

Coronaviruses (family Coronaviridae, genera Alphacoronavirus, Betacoronavirus) are dangerous viral pathogens that have caused three outbreaks of severe respiratory diseases, SARS, MERS, COVID-19. In Russia, data on coronaviruses in natural reservoirs are limited, as investigations began only during the COVID-19 pandemic.The aim. To study the diversity of coronaviruses among rodents and insectivores in the Republic of Altai.Materials and methods. Rodents (n = 67) and shrews (n = 52) were captured in 2022. Samples were analyzed by reverse transcription-polymerase chain reaction followed by sequencing.Results and conclusions. Four samples from rodents (Myodes rutilus, M. glareolus, Apodemus peninsulae, A. agrarius) and two samples from an insectivore (Crocidura sibirica) were positive for coronaviruses, among which three different coronaviruses were detected. Rodent-borne coronaviruses are classified in the genus Betacoronavirus, subgenera Embecovirus, and have shown host associated clustering. The nucleotide sequences of Siberian coronaviruses from rodents were identical for closely related species (M. rutilus and M. glareolus, A. agrarius and A. peninsulae) and close (> 94 % homology) to previously published sequences in each of the groups of carriers found in the territory Novosibirsk region, Europe and China. The coronavirus identified from the insectivore, possibly belonging to a new subgenera of the family Coronaviridae, has also been assigned to the genus Betacoronavirus.Conclusion. Five species of natural carriers of three different coronaviruses were detected in the Altai Republic. A high level of identity of coronaviruses genomes from rodents has been revealed, indicating a relatively low rate of their evolution.
Online service for interpretation of the resistance prediction results to bedaquiline by the molecular data
Authors: Sinkov V. V. , Kondratov I. G. , Ogarkov O. B. , Zhdanova S. N. , Noskov A. P. , Khromova P. A. , Orlova E. A. , Labygina A. V. , Rychkova L. V. , Kolesnikova L. I. 
Published: January 2024

Background. Bedaquiline is a new and promising anti-tuberculosis drug, but longterm use requires resistance. This is due to mutations in the atpE and mmpR genes in M. tuberculosis (MBT).The aim of the research was to test a system for automated interpretation of results for predicting resistance to bedaquiline by the molecular data.Materials and methods. DNA was isolated from strains of M. tuberculosis in the Irkutsk region and Yakutia. The total quantity of DNA samples was 27 strains from Yakutia and 21 strains from the Irkutsk region. The study of MBT genomes was carried out on the DNA previously obtained by the authors in the territories of the Irkutsk region (n = 5), Yakutia (n = 4), Buryatia (n = 3), Zabaykalskiy kray (n = 4) and the Far East (n = 8). We used the BSATool program to detect bedaquiline resistance based on Sanger and genomic data. Sanger sequencing analyzed the atpE and mmpR genes, and whole genome sequencing examined mutations in the same sequences, as well as additionally in mmpL5, mmpS5, Rv0678, Rv1979c, and pepQ.Results. Complete agreement between the phenotypic and genotypic analysis of resistance to bedaquiline was found for three strains from Yakutia. One genome with significant mutations to bedaquiline was identified. A conclusion was made about the importance of molecular analysis of target genes with subsequent detection of resistance to bedaquiline in silico.
Cytotoxic effect of the VVGMCSF-Lact oncolytic virus against 3D cultures of human glioblastoma cells U-87 MG
Authors: Dymova M. A. , Shnaider T. A. , Chechetkina S. A. , Petrov G. O. , Malysheva D. O. , Drokov D. V. , Ageenko A. B. , Vasileva N. S. , Richter V. A. , Kuligina E. V. 
Published: January 2024

Background. One of the promising methods of treating tumors is virotherapy, which is based on direct lysis of cancer cells by a virus and a virus-mediated antitumor immune response of the body. For the recombinant vaccinia virus strain VVGMCSF-Lact, producing human GMCSF and the oncotoxic protein lactaptin, cytotoxic and antitumor effects were shown in experiments in vitro and in vivo, respectively, when using adhesive cultures of U-87 MG human glioblastoma cells. 3D cultures are a more relevant tumor model than adhesive models, as they more fully reflect the realistic scenario of cancer development, as well as the response of the tumor to anticancer therapy.The aim. To evaluate the cytotoxic effect of the oncolytic virus VV-GMCSF-Lact against 3D cultures of human glioblastoma U-87 MG.Materials and methods. The following methods were used in the work: cultivation of 3D cell cultures, cytofluorometry, microscopic analysis, virus titration, statistical analysis.Results. U-87 MG cells were transduced with a lentiviral vector carrying the GFP reporter gene. The cytotoxicity of the VV-GMCSF-Lact virus (IC50) against the studied cells was 0.024 PFU/cell. U-87 MG cells were cultured under conditions for the formation of 3D structures. Microscopic analysis showed the oncolytic effect of the virus on the cells of 3D cultures as early as 24 hours after the start of incubation. Flow cytometry showed an increase in the granularity of glioblastoma cells under the action of the virus, which indicates active replication of the virus in the cells. The virus titer was 0.44 PFU/cell.Conclusions. The recombinant VV-GMCSF-Lact virus has a cytotoxic effect on 3D human glioblastoma U-87 MG cell cultures and actively replicates in them. In the future, to test the oncolytic effect of VV-GMCSF-Lact, it is planned to use not only 3D human glioblastoma cultures, but also cerebral organelles obtained in the process of cocultivation of glioblastoma cells and induced human pluripotent cells.
Attitude and awareness of Indian parents from Kerala state towards children’s vaccination at the COVID-19 pandemic background
Authors: Aaromal Sureshkumar Ajitha , Novikova E. A. , Abhiramy Suprasannan , Manu Krishna Maniyan Girija , Vanyarkinа A. S. , Moskaleva E. V. , Kazantseva E. D. , Petrova A. G. , Rychkova L. V. 
Published: January 2024

Background. Vaccination coverage of children in India is not sufficient since the COVID-19 pandemic (less than 90 %). This may lead to low adherence of parents to children’s vaccination.The aim. To study parental attitudes and awareness towards children vaccination programs in India at the COVID-19 pandemic background.Methods. Two hundred and fourteen participants from Kerala state (India) took part in the descriptive cross-sectional study via survey method. The survey was prepared with Google form according the principles of anonymity.Results. Indian parents demonstrated good adherence towards children’s vaccination, 98.6 % (95% confidence interval (CI): 95.9–99.5) of them vaccinated their child, and if vaccination appointment had to be rescheduled 84.6 % (95% CI: 79.1–88.8) of them vaccinated children after. Most of Indians (68.7 %; 95% CI: 62.1–74.5) preferred to vaccinate children in state clinics, however, 28.5 % (95% CI: 22.8–34.8) chose private clinics. Information about diseases that vaccines can prevent, vaccine safety, and side effects 47.2 % (95% CI: 40.6–53.8) of parents got from public pediatricians, 50.9 % (95% CI: 44.2–57.5) – from private pediatricians, and 10.3 % (95% CI: 6.8–15.0) – from complementary and alternative medicine practitioners. Over 80 % of Indians were informed about vaccination through mass media (83.6%; 95% CI: 78.1–87.9). Indian parents showed low awareness about vaccination, because 63.1 % (95% CI: 56.4–69.2) of parents wanted to know more about vaccination. Moreover, before vaccination 21.5 % (95% CI: 16.5–27.4) of them were not informed by a doctor about health benefits and possible risks for their children.Conclusion. In the COVID-19 pandemic Indian parents showed good attitude towards vaccination and low awareness in vaccination questions.
Assessment of the actual nutrition of rural adolescents of the Irkutsk region because of revision of the norms of physiological needs for energy and nutrients
Authors: Rychkova L. V. , Pogodina A. V. , Astakhova T. A. , Lebedeva L. N. 
Published: January 2024

Background. The rational nutrition of the child population is given great medical importance as a factor in preserving the health and development of the child. A complete and balanced diet in terms of the content of basic nutrients ensures the normal growth and development of the child’s body.The aim. To analyze of the actual nutrition of adolescents living in rural areas of the Irkutsk region.Materials and methods. The study involved 69 rural adolescents aged 11–17 years (34 boys, 35 girls). The actual nutrition was studied by the method of 24-hour nutrition reproduction. The energy value of the diet was determined, the nature of the provision of the diet with basic macro- and microelements was studied. The obtained values were compared with the norms of physiological needs for energy and nutrients in 2008 and 2021.Results. The analysis of actual nutrition revealed deviations from the principles of healthy nutrition: insufficient energy value of the diet, deficiency of proteins and fats. The diet of adolescents was characterized by an insufficient content of the main groups of macro- and micronutrients – vitamins A, C and D, essential trace elements, and a deficiency of dietary fiber. The diet of adolescents was characterized by increased sodium intake. The calculated ratio of proteins, fats, carbohydrates indicated a carbohydrate type of diet.Conclusion. Despite the great attention to the problem of balanced nutrition of adolescents, the question of the impact of nutrition on the health of a teenager, considering the regional factor, remains open. Recommendations for the development of a regional program for the organization of proper nutrition for school-age children are of great practical importance.
Features of drug-drug interactions rivaroxaban and calcium channel blockers depending on the ABCB1 genotype (rs1045642 and rs4148738) in patients 80 years of age and older with non-valvular atrial fibrillation
Authors: Sychev D. A. , Mirzaev K. B. , Cherniaeva M. S. , Shakhgildyan N. V. , Abdullaev Sh. P. , Denisenko N. P. , Sozaeva Zh. A. , Kachanova A. A. , Shastina V. R. , Gorbatenkova S. V. 
Published: January 2024

Background. The use of P-glycoprotein (P-gp) inhibitors and carriage of certain ABCB1 polymorphisms can lead to increased concentrations of rivaroxaban and the development of bleeding.The aim of the study. To study the features of drug-drug interactions (DDI) of rivaroxaban in patients over 80 years of age with non-valvular atrial fibrillation depending on the ABCB1 genotype (rs1045642 and rs4148738) using the example of verapamil (P-gp inhibitor) and amlodipine.Materials and methods. One hundred and twenty-eight patients were examined (median age – 87.5 [83–90] years). Genotyping, determination of the minimum equilibrium concentration of rivaroxaban (Cmin, ss), with standardization for the daily dose (Cmin, ss/D), coagulogram and analysis of medical documentation for the presence of clinically relevant non-major bleeding (CRNM) were carried out. Analysis of CRNM was performed depending on the ABCB1 genotype.Results. The use of rivaroxaban with verapamil in comparison with patients not taking calcium channel blockers (CCBs) leads to high Cmin, ss values in the CC genotype (rs1045642, rs4148738); Сmin, ss and Сmin, ss/D in the CT genotype (rs1045642); prothrombin time in the CC genotype (rs1045642), more frequent occurrence of CRNM in the TT genotype (rs1045642, rs4148738). In comparison with patients taking amlodipine, it leads to high Cmin, ss values in the CT genotype (rs1045642), a more frequent occurrence of CRNM in the TT genotype (rs1045642, rs4148738). The use of rivaroxaban with amlodipine in comparison with patients not taking CCBs leads to high Cmin, ss and Cmin, ss/D values in the CC genotype (rs1045642) (p < 0.017).Conclusion. The use of verapamil with rivaroxaban in ABCB1 TT carriers (rs4148738 and rs4148738) leads to the development of CRNM in 75 and 78 % of cases, respectively. In patients taking rivaroxaban, it is advisable to test the ABCB1 genotype (rs4148738 and rs4148738) before adding a P-gp inhibitor to therapy.