bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Notch signaling-related lncRNA signature for predicting prognosis and therapeutic response in clear cell renal cell carcinoma
Authors: Zhang Lulu , Li Yulei , Cai Bin , Chen Jiajun , Zhao Keyuan , Li Mengyao , Lang Juan , Wang Kaifang , Pan Shouhua , Zhu Ke 
Published: November 2023

AbstractIncreasing evidence has confirmed the vital role of Notch signaling in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). The underlying function of long non-coding RNA (lncRNA) related to Notch signaling in ccRCC remains unclear. In present study, the prognostic value and therapeutic strategy of Notch signaling-related lncRNA are comprehensively explored in ccRCC. In total, we acquired 1422 NSRlncRNAs, of which 41 lncRNAs were identified the key NSRlncRNAs associated with the occurrence of ccRCC. The prognostic signature containing five NSRlncRNAs (AC092611.2, NNT-AS1, AGAP2-AS1, AC147651.3, and AC007406.3) was established and validated, and the ccRCC patients were clustered into the high- and low-risk groups. The overall survival of patients in the low-risk group were much more favorable than those in the high-risk group. Multivariate Cox regression analysis indicated that the risk score was an independent prognostic biomarker. Based on the risk score and clinical variables, a nomogram for predicting prognosis of ccRCC patients was constructed, and the calibration curves and DCA curves showed the superior predictive ability of nomogram. The risk score was correlated with immune cell infiltration, targeted therapy or chemotherapy sensitivity, and multiple oncogenic pathways. Additionally, consensus clustering analysis stratified the ccRCC patients into four clusters with obvious different outcomes, immune microenvironments, and expression of immune checkpoints. The constructed NSRlncRNA-based signature might serve as a potential biomarker for predicting prognosis and response to immunotherapy or targeted therapy in patients with ccRCC.
Modelling local and general quantum mechanical properties with attention-based pooling
Authors: Buterez David , Janet Jon Paul , Kiddle Steven J. , Oglic Dino , Liò Pietro 
Published: November 2023

AbstractAtom-centred neural networks represent the state-of-the-art for approximating the quantum chemical properties of molecules, such as internal energies. While the design of machine learning architectures that respect chemical principles has continued to advance, the final atom pooling operation that is necessary to convert from atomic to molecular representations in most models remains relatively undeveloped. The most common choices, sum and average pooling, compute molecular representations that are naturally a good fit for many physical properties, while satisfying properties such as permutation invariance which are desirable from a geometric deep learning perspective. However, there are growing concerns that such simplistic functions might have limited representational power, while also being suboptimal for physical properties that are highly localised or intensive. Based on recent advances in graph representation learning, we investigate the use of a learnable pooling function that leverages an attention mechanism to model interactions between atom representations. The proposed pooling operation is a drop-in replacement requiring no changes to any of the other architectural components. Using SchNet and DimeNet++ as starting models, we demonstrate consistent uplifts in performance compared to sum and mean pooling and a recent physics-aware pooling operation designed specifically for orbital energies, on several datasets, properties, and levels of theory, with up to 85% improvements depending on the specific task.
Nearly half of the world is suitable for diversified farming for sustainable intensification
Authors: Kamau Hannah , Roman Shahrear , Biber-Freudenberger Lisa 
Published: November 2023

AbstractSustainable intensification, defined as increasing production per unit without harming the environment, has potential to transform agricultural systems. While questions persist about which practices and conditions lead to sustainable intensification, diversification has gained prominence as a proposed solution. Here we apply niche modelling using maximum entropy modelling approach to predict the global spatial distribution of profitable diversified farming systems under different socio-economic conditions. We found about 47% of the world is suitable for profitable diversified systems with a larger area in the global North. When we combined our findings with knowledge about biophysical potential for cropland expansion and intensification, we found that different areas could benefit from diversification to achieve sustainable intensification through cropland expansion (e.g., Europe), intensification (e.g., sub-tropics and tropics), or both (e.g., West Africa). With these results, we provide insights in which way diversification can support sustainable intensification and contribute to the debate on land sharing vs sparing.
Les tumeurs hépato-biliaires chez le chien et le chat
Authors: Sayag David 
Published: November 2023

Les tumeurs hépatobiliaires représentent approximativement 2 % de l’ensemble des néoplasies chez le chien et le chat, et peuvent être primitives (adénomes, hépatocarcinomes, cholangiocarcinomes, hémangiosarcomes, lymphomes, tumeurs neuroendocrines…) ou secondaires à une maladie métastatique. Les signes cliniques d’appel sont généralement non spécifiques, bien qu’une hypoglycémie paranéoplasique soit rarement identifiée en pratique. Les examens d’imagerie, et notamment l’échographie et la tomodensitométrie, permettent d’identifier une masse, des nodules ou une modification de l’aspect du parenchyme hépatique compatible avec une infiltration diffuse. Le diagnostic de certitude repose sur un examen histopathologique. Les stratégies thérapeutiques demeurent dépendantes de la nature primitive de la tumeur, et peuvent inclure la chirurgie (notamment lors de forme massique), la chimiothérapie (notamment dans les lymphomes et mastocytomes), les thérapies ciblées, et la radiothérapie. L’oncologie interventionnelle (ablation micro-ondes, chimio-embolisation) tend à offrir de nouvelles perspectives dans la prise en charge future de ces tumeurs.
Es ist kompliziert
Authors: Heinrich Jörg 
Published: November 2023

ZusammenfassungAuch für die Pädiatrie ist die PPR 2.0 ein großer Fortschritt und wird zukünftig den Personalbedarf realistischer abbilden. Beim Start in die Testphase haperte es aber schon mal gewaltig am Zeitplan, an den Materialien und an der Unterstützung.
Das Fibromyalgie-Syndrom ganzheitlich behandeln
Authors: Lohmann Maria 
Published: November 2023

ZusammenfassungBeim Fibromyalgie-Syndrom handelt es sich um eine chronische Schmerzerkrankung, die in der Regel lebenslang besteht. Wichtig ist, gemeinsam mit dem Patienten realistische Ziele zu setzen im Sinne einer Verbesserung der Lebensqualität und Funktionsfähigkeit sowie der Erlangung eines Gefühls der Selbstwirksamkeit. Grundprinzip der klassischen, ganzheitlichen Naturheilkunde ist die Umstimmung des Organismus. Konkret heißt das beim Fibromyalgie-Syndrom, Impulse zu geben, die den Körper zu heilsamen Reaktionen befähigen. Als Bausteine gehören zu diesen Regulationsimpulsen Heilfasten, basenreiche Ernährung, unspezifische Reiztherapien (in erster Linie Wärmeanwendungen), Hydrotherapie, Bewegung und Anpassung der Lebensführung.
PPR im Praxistest
Authors: Winkel Nicole 
Published: November 2023

ZusammenfassungBevor die PPR 2.0 2024 bundesweit eingeführt wird, fanden in den vergangenen Monaten Testläufe in ausgewählten Kliniken statt. Das Ziel: eine empirische Auswertung von Daten zur Ist- und Soll-Besetzung nach der PPR 2.0. Lesen Sie hier von den Erfahrungen der Knappschaft Kliniken.
Way Forward in Improving Rhinoplasty Outcomes
Authors: Xavier Rui 
Published: November 2023

AbstractRhinoplasty is an elective surgical procedure to attain an aesthetic and functional improvement of the nose. The level of expectation of the patient—and the surgeon—regarding the outcome of a rhinoplasty is usually high, and any result that is less than perfect can be seen as a failure. To achieve consistently good results in rhinoplasty, the surgeon should be meticulous at every step of the procedure. Fully understanding the patient's desires, careful preoperative evaluation of the face, and proper selection of patients are crucial to achieving improved outcomes. Furthermore, an individually tailored surgical planning according to the unique features of the specific case, preferring remodeling over resection and reinforcing the nasal framework support, and careful surgical execution will likely ensure a satisfactory and long-lasting surgical outcome. Rhinoplasty requires lifelong dedication of the surgeon for providing the best outcomes to patients entrust their noses to the surgeon's surgical skills. The rhinoplasty surgeon has been labeled an “eternal student,” and this should reflect the delicateness and humbleness of the rhinoplasty surgeon.
Effectiveness of ChatGPT in Identifying and Accurately Guiding Patients in Rhinoplasty Complications
Authors: Soto-Galindo Germán A. , Capelleras Marta , Cruellas Marc , Apaydin Fazil 
Published: November 2023

AbstractPostoperative complications in rhinoplasty require prompt intervention for optimal outcomes. ChatGPT, an artificial intelligence (AI) tool, offers potential for assisting in postoperative care.This study aims to assess ChatGPT's effectiveness in providing guidance for various rhinoplasty complications.Different complication scenarios were input into ChatGPT. Responses were categorized into “Contact Surgeon” or “Follow Postoperative Instructions.”ChatGPT consistently advised immediate surgeon contact for infection. For other complications, it recommended monitoring and adhering to instructions while suggesting surgeon contact if concerns persisted.ChatGPT shows promise in aiding patients' postoperative care by accurately identifying cases necessitating communication with surgeons or emergency care. This research underscores AI's potential in enhancing patient-centered care and contributes to the evolving landscape of health care practices.
Mild Metal-Free 1,2-Dichlorination of Alkynes by NCS-PPh3-H2O System
Authors: Umezawa Taiki , Yuan Jianan , Prakoso Nurcahyo Iman , Morozumi Tatsuya 
Published: November 2023

AbstractFacile dichlorination of alkynes to give 1,2-dichloroalkenes is described. Previous studies for the synthesis of the 1,2-dichloroalkenes from the corresponding alkynes require stoichiometric amount of copper salt, preparation of the chlorinating reagent from hazardous compounds such as molecular chlorine, and highly acidic conditions. In this paper, only ubiquitous reagents, NCS-PPh3-H2O, are used to prepare the 1,2-dichloroalkenes from the alkynes under mild conditions. Various functional groups such as esters, ethers or carbamates were tolerated under these reaction conditions.
Cobalt Catalysis: C7 Alkynylation of Indolines with a Bromoalkyne
Authors: Sharma Upendra , Manisha Manisha , Gupta Shiv Shankar 
Published: November 2023

AbstractA method for the cobalt-catalyzed C-7 alkynylation of indolines with (bromoethynyl)triisopropylsilane under mild conditions is described, leading to a diverse range of alkynylated indolines in good to excellent yields. Kinetic isotope studies indicate that the formation of a cobaltacycle might be the turnover-limiting step. Additionally, a gram-scale synthesis and oxidation of an indoline to an indole have been carried out successfully with excellent yields.
One-Flow Operation via 4-Bromopyridine Enables Flash Synthesis of AChE Inhibitor
Authors: Nagaki Aiichiro , Soutome Hiroki , Kimuro Yusuke , Kawaguchi Tomoko , Yoo Dong-eun , Yao Yiyue , Oshida Shuto , Nakayama Hiroki , Iwata Masatomo , Ebisawa Ruka , Kikuchi Ryuhei , Tomite Kyosuke , Wada Shuto , Ashikari Yosuke 
Published: November 2023

Abstract4-Bromopyridine is a building block that can be converted into valuable compounds, but due to its low stability, it is commercially available in the form of hydrochloride salt. Therefore, the hydrochloride salt is usually desalted with a basic aqueous solution and dried before organic reaction. In this study, to simplify the preparation and reaction procedure of 4-bromopyridine, multiple operations, desalting with a base, separation of the aqueous layer, and subsequent halogen–lithium exchange reaction were integrated into a single flow reaction. The reaction sequence was completed within 20 seconds and the yields were higher than the conventional methods. This is because the subsequent reaction can be performed immediately after the generation of 4-bromopyridine, which is unstable under ambient conditions.
New Synthesis of Pyrazolo[3,4-b]pyridine Derivatives Based on 5-Aminopyrazole and Azlactones
Authors: Fisyuk Alexander S. , Shuvalov Vladislav Yu. , Shatsauskas Anton L. , Zheleznova Tatyana Yu. , Kostyuchenko Anastasia S. 
Published: November 2023

AbstractReaction of 5-amino-3-methyl-1-phenyl-1H-pyrazole with azlactones under solvent-free conditions with heating furnished tetrahydro-1H-pyrazolo[3,4-b]pyridines. The latter were converted to oxazolo[5,4-b]pyrazolo[4,3-e]pyridines by the action with POCl3 on air. Further reaction of oxazolo[5,4-b]pyrazolo[4,3-e]pyridines with hydrazine hydrate and alkali led to the formation of 5-amino-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-ones, which reacted with aluminum chloride to yield 3,4-dihydro-5H-pyrazolo[4,3-f][1,7]naphthyridin-5-ones. Some of the synthesized compounds show antioxidant activity or are effective phosphors.
Quality and Reliability Analysis of YouTube as a Source of Patient Information on de Quervain's Tenosynovitis
Authors: Kim Jason H. , Hoy John F. , Shuman Samuel L. , Ahmad Farhan , Simcock Xavier C. 
Published: November 2023

Abstract
Purpose This study seeks to evaluate the quality and reliability of information regarding de Quervain's tenosynovitis on YouTube.
Materials and Methods A search on the YouTube was performed using the keywords de Quervain's tenosynovitis, and the first 50 videos were evaluated. Video characteristics including views, content type, and video upload source were recorded. Video reliability was assessed using the Journal of the American Medical Association (JAMA) benchmark criteria. Video quality was assessed using the Global Quality Score (GQS) and a novel de Quervain's Tenosynovitis-Specific Score (DQT-SS).
Results The total number of views for all videos evaluated was 5,508,498 (mean, 110,169.96 ± 155,667.07). Video reliability and quality metrics were low, with a mean JAMA score of 2.17 ± 0.82 out of 4, a mean GQS of 2.49 ± 1.28 out of 5, and a mean DQT-SS of 4.53 ± 2.35 out of 11. Significant between-group effects were found for the video source and DQT-SS (p = 0.027), as well as between content type and JAMA score (p = 0.027), GQS (p = 0.003), and DQT-SS (p = 0.003). Positive independent predictors of DQT-SS included video duration in seconds (β = 0.391) and disease-specific information content type (β = 0.648).
Conclusion Videos on YouTube regarding de Quervain's tenosynovitis were frequently viewed; however, the information present was of low quality and reliability. Physician-uploaded videos had the highest mean JAMA scores, GQS, and DQT-SS, but had the second-lowest mean number of views of video sources. Patients should receive proper in-office education and be directed toward reputable resources for their orthopaedic conditions.
DIEP Flap for Head and Neck Reconstruction: An Underutilized Option!
Authors: Jaiswal Dushyant , Borle Firoz , Mathews Saumya , Mantri Mayur , Kumar Vineet , Bindu Ameya , Yadav Prabha , Shankhdhar Vinay Kant 
Published: November 2023

Abstract
Background The deep inferior epigastric artery perforator (DIEP) flap is a workhorse flap for breast reconstruction. Its use for head and neck (HN) reconstruction is rare. Abdomen provides a donor site abundant in skin and subcutaneous tissue, amenable to primary closure; sizeable, robust, and consistent perforators and a long, sizeable pedicle for comfortable microvascular anastomosis. Its offers all the donor variables needed for HN reconstruction in abundance.
Methods It is a quasiexperimental design study. DIEP flap use for HN reconstruction in our series was opportunistic, that is, when donor site matched the defect. Cases that had very thick thighs and lesser bulk in abdomen and cases that had very thin thighs but much more bulk in abdomen were considered for reconstruction using DIEP flap.
Results The DIEP flap was done in 11 cases for HN reconstruction. There were two re-explorations during postoperative period: one flap loss and another had partial necrosis.
Conclusion Abdomen is an excellent donor site option for HN reconstruction in selected cases, especially when harvested as a perforator flap.
European Paediatric Surgeons' Association Survey on the Adherence to EAU/ESPU Guidelines in the Management of Undescended Testes
Authors: Aubert Ophelia , Zaidan Hind , Garnier Hanna , Saxena Amulya K. , Cascio Salvatore 
Published: November 2023

Abstract
Introduction The aim of this study was to assess the adherence to the European Association of Urology (EAU)/European Society for Pediatric Urology (ESPU) 2016 guidelines in the management of undescended testes (UDT).
Materials and Methods An online questionnaire was sent in 2023 to members of the European Paediatric Surgeons' Association (EUPSA).
Results Among 157 members, 46 and 44% perform orchidopexy before 12 and 18 months, respectively. In total, 92% recommend conservative management of retractile testes and 58% offer close follow-up. In case of nonpalpable testes, 78% favor laparoscopy and 18% ultrasonography. If a peeping testicle is identified at laparoscopy, 76% perform a single-stage orchidopexy. In case of a high testicle, a staged procedure is preferred (84%). Management of blind-ending spermatic vessel is heterogenous with a majority ending the operation, followed by exploration of the inguinal canal and removal of the testicular nubbin with optional fixation of the contralateral testis. Only a minority recommends hormonal therapy to improve fertility potential in bilateral UDT. A majority (59%) discuss testis removal in UDT in postpubertal boys. In addition, 77% declare following the EAU/ESPU guidelines. Unawareness of guidelines was the most common reason cited for nonadherence. International guidelines were found to have the greatest influence on clinical practice; however, personal experience and institutional practice seem to play an important role.
Conclusion Most recommendations of the EAU/ESPU guidelines are being followed by EUPSA members; however, personal and institutional practice impact decision making. Hormonal therapy in bilateral UDT, management of vanishing testes, and UDT in postpubertal boys could be improved.
Internet use and higher farmer participation in domestic waste sorting: micro-survey data from 2126 farming households in rural China
Authors: Chen Fan , Zhang Can , Wang Wenna , Wei Hong 
Published: November 2023

AbstractIn the context of the digital economy, understanding the impact of digital participation on farmers’ environmental behavior is crucial for promoting environmental literacy and improving quality of life. This study focuses on the influence of internet use on domestic waste sorting among farm households in rural areas of eastern, central, and western China, based on data from a micro survey conducted in 2126 households. The study utilizes an ordered probability model to examine the impact of internet use on waste sorting behavior and explores any heterogeneity in this relationship. The results reveal that internet use significantly increases the likelihood of farmers participating in domestic waste sorting. This finding remains consistent even after conducting robustness tests. Furthermore, the study demonstrates that internet use reduces the probability of non-participation in waste separation by 14.9%, while increasing the proportion of waste sorting into two, three, and four categories by 3.86, 5.99, and 5.04%, respectively. In other words, farmers who use the internet are more likely to engage in proper waste separation practices. Heterogeneity analysis indicates that the promotion of internet use facilitates information access for traditionally marginalized groups, such as women, older individuals, those with low income, and those with low education levels. Consequently, these groups are more likely to participate in household waste sorting. This study serves as an important reference for developing countries and regions that aim to enhance residential waste participation through internet use.
Emergence of high-level azithromycin-resistant Neisseria gonorrhoeae causing male urethritis in Johannesburg, South Africa, 2021
Authors: Müller Etienne E. , Gumede Lindy Y. E. , Maseko Dumisile V. , Mahlangu Mahlape P. , Venter Johanna M. E. , Da Costa Dias Bianca , Nhlapho Duduzile , Kularatne Ranmini S. 
Published: November 2023

Background In South Africa, Neisseria gonorrhoeae, which is the predominant cause of male urethritis, is treated syndromically using dual ceftriaxone and azithromycin therapy. We determined antimicrobial susceptibilities of N. gonorrhoeae isolates from urethral discharge specimens, and genetically characterised those with elevated minimum inhibitory concentrations (MICs) for first-line antimicrobials. Methods Routine antimicrobial susceptibility testing (AST) of N. gonorrhoeae isolates included E-test for ceftriaxone, cefixime and gentamicin and agar dilution for azithromycin and spectinomycin. Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) was performed for isolates with elevated MICs to identify antimicrobial resistance (AMR) determinants, and Neisseria gonorrhoeae Multi-Antigen Sequence Typing (NG-MAST) was used to determine strain relatedness. Results N. gonorrhoeae was cultured from urethral discharge swab specimens obtained from 196 of 238 (82.4%) men presenting to a primary healthcare facility in Johannesburg in 2021. All viable isolates were susceptible to extended-spectrum cephalosporins. Four isolates had high azithromycin MICs ranging from 32 mg/L to >256 mg/L and grouped into two novel NG-MAST and NG-STAR groups. Two isolates from Group 1 (NG-MAST ST20366, NG-STAR ST4322) contained mutated mtrR (G45D) and 23S rRNA (A2059G) alleles, while the two isolates from Group 2 (NG-MAST ST20367, NG-STAR ST4323) had different mutations in mtrR (A39T) and 23S rRNA (C2611T). Conclusions We report the first cases of high-level azithromycin resistance in N. gonorrhoeae from South Africa. Continued AMR surveillance is critical to detect increasing azithromycin resistance prevalence in N. gonorrhoeae, which may justify future modifications to the STI syndromic management guidelines.
Tuning electrical and optical properties of InAs/GaAs1−x
Sb
x
quantum dots
Authors: Bao Yidi , Liu Wen , Liu Qing , Chen Xiaoling , Yang Fuhua , Wang Xiaodong 
Published: November 2023

Abstract
Understanding the electrical and optical properties of InAs/GaAs(Sb) quantum dots (QDs) is essential for designing and improving the performance of related semiconductor QD devices. In this paper, the effects of In segregation, QD size, capping layer thickness and Sb composition on the electrical and optical properties of type I and type II InAs/GaAs1−x
Sb
x
(

0

⩽
x
⩽

1

) QDs are systematically investigated and general regularities are summarized. The comparisons of electron distribution probabilities, interband and intraband transition energies and absorption coefficients show that In segregation and QD size have a strong influence on the electron energy level positions of InAs QDs and that the trade-offs between absorption peak energy, absorption intensity and radiative lifetime of InAs/GaAs1−x
Sb
x
QDs can be optimized by adjusting the thickness and Sb composition of the GaAs1−x
Sb
x
capping layer. The results obtained are promising for the applications in the pre-design and performance feedback of the QD devices such as QD lasers, QD infrared detectors and intermediate band solar cells.