bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of COVID-19 patients in the use of bioethical principles and the physician-patient relationship: a qualitative approach
Authors: Cantú Quintanilla Guillermo , Gómez-Guerrero Irma Eloisa , Aguiñaga-Chiñas Nuria , López Cervantes Mariana , Jaramillo Flores Ignacio David , Slon Rodríguez Pedro Alonso , Bravo Vargas Carlos Francisco , Arroyo-Valerio America , García-Higuera María del Carmen 
Published: February 2024

Abstract
Background
The COVID-19 pandemic has influenced the approach to the health-disease system, raising the question about the principles of bioethics present in physician–patient relations. The principles while widely accepted may not be sufficient for a comprehensive ethical analysis. Therefore, the aim of this study was to explore the perception of these principles and the physician–patient relationship during a hospital stay through a qualitative approach.

Method
Sixteen semi-structured interviews took place to know the patients’ perception during their 2020 hospitalization for COVID-19. The data was analyzed through the constant comparison method, creating categories and comparing them. In the end, seven categories were established and were grouped in three: bioethical principles (dignity, charity, vulnerability, autonomy), doctor-patient relationship (participant commitment, informed consent, health staff-patient relationship) and the experience of the disease (illness, the role of the family).

Results
The research found that most patients described a positive experience, with the feeling of having been well cared for with no sense of discrimination or injustice done. The majority also reported that their autonomy was respected in the treatment decisions. The evaluation of these attitudes is an area of opportunity, especially when the patients' vulnerability is at risk.

Conclusions
The ethics of virtue offers a better reflection of how human beings manifest themselves by emphasizing the development of virtuous character and behaviors that allow them to realize their values in life. Authorized by the Research Ethics Committee with registration: DI/18/105-B/3/308.
Individual and community-level factors associated with women’s utilization of postnatal care services in Uganda, 2016: a multilevel and spatial analysis
Authors: Towongo Moses Festo , Ngome Enock , Navaneetham Kannan , Letamo Gobopamang 
Published: February 2024

Abstract
Background
Over time, Uganda has experienced high levels of maternal mortality (435 deaths per 100,000 live births in 2006 to 336 deaths per 100,000 live births in 2016). The persistence of high levels of maternal mortality jeopardizes the achievement of Sustainable Development Goal (SDG) 3.1, which calls for reducing maternal mortality to 70 deaths per 100,000 live births by 2030. Conversely, the utilization of postnatal care (PNC) services in Uganda remained very low and has varied across regions. This study examined the individual and community-level factors influencing women’s utilization of postnatal care services in Uganda.

Methods
Secondary data from the 2016 Uganda Demographic and Health Survey (UDHS) were used in this study. The study population consisted of women aged 15 to 49 who reported giving birth in the five years preceding the 2016 UDHS survey. The factors associated with postnatal care services were identified using multilevel binary logistic regression and spatial analysis.

Results
The result shows that the prevalence of postnatal care service utilization in Uganda was low (58.3%) compared to the World Health Organization (WHO) target of 100%. The univariate analysis shows that 13.7% of women were adolescents, 79% were of higher parity, and 70.4% had primary/no formal education, of which 76.6% resided in rural areas. On the other hand, the multilevel analysis results showed that women aged 20-29 years and 30-39 years were also found to be more likely to use PNC services (AOR = 1.2, 95% CI: 1.01-1.47). Women who received quality ANC (AOR = 2.1, 95% CI: 1.78–2.36) were more likely to use postnatal care services than their counterparts. At the community level, women who lived in media-saturated communities were more likely to use postnatal care services (AOR = 1.3, 95% CI: 1.01–1.65). The spatial analysis found that the Central, Eastern, and Northern regions were the areas of hotspots in the utilization of postnatal care services.

Conclusion
This study found that age, parity, level of education, place of residence, employment status, quality of the content of antenatal care, and community media saturation were the predictors of postnatal care service utilization. The spatial analysis showed that the spatial distributions of postnatal care service utilization were significantly varied across Uganda. The government must expand access to various forms of media throughout the country to increase PNC utilization.
Peripheral vertigo and subsequent risk of depression and anxiety disorders: a prospective cohort study using the UK Biobank
Authors: Chen Xiaowan , Wei Dang , Fang Fang , Song Huan , Yin Li , Kaijser Magnus , Gurholt Tiril Pedersen , Andreassen Ole Andreas , Valdimarsdóttir Unnur , Hu Kejia , Duan Maoli 
Published: February 2024

Abstract
Background
Peripheral vertigo is often comorbid with psychiatric disorders. However, no longitudinal study has quantified the association between peripheral vertigo and risk of psychiatric disorders. Furthermore, it remains unknown how the white matter integrity of frontal-limbic network relates to the putative peripheral vertigo-psychiatric disorder link.

Methods
We conducted a cohort study including 452,053 participants of the UK Biobank with a follow-up from 2006 through 2021. We assessed the risks of depression and anxiety disorders in relation to a hospitalization episode involving peripheral vertigo using Cox proportional hazards models. We also examined the associations of peripheral vertigo, depression, and anxiety with MRI fractional anisotropy (FA) in a subsample with brain MRI data (N = 36,087), using multivariable linear regression.

Results
Individuals with an inpatient diagnosis of peripheral vertigo had elevated risks of incident depression (hazard ratio (HR) 2.18; 95% confidence interval (CI) 1.79–2.67) and anxiety (HR 2.11; 95% CI 1.71–2.61), compared to others, particularly within 2 years after hospitalization (HR for depression 2.91; 95% CI 2.04–4.15; HR for anxiety 4.92; 95% CI 3.62–6.69). Depression was associated with lower FA in most studied white matter regions, whereas anxiety and peripheral vertigo did not show statistically significant associations with FA.

Conclusions
Individuals with an inpatient diagnosis of peripheral vertigo have increased subsequent risks of depression and anxiety disorders, especially within 2 years after hospitalization. Our findings further indicate a link between depression and lower microstructural connectivity as well as integrity beyond the frontal-limbic network.
Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response
Authors: Sevoz-Couche Caroline , Patout Maxime , Charbit Beny , Similowski Thomas , Straus Christian 
Published: February 2024

AbstractAfter a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.Clinical Trials Identifier NCT01243697
Case report of penile squamous cell carcinoma continuous treatment with BRCA2 mutation
Authors: Zhang Qing , Li Yaping , Zhang Yanrui , Deng Zhiping , Ding Yi 
Published: February 2024

Abstract
Background
Penile squamous cell carcinoma (PSCC) is a highly aggressive malignancy with a poor prognosis. BRCA1/2 mutations are associated with impaired DNA double-strand break repair and are among the common mutations in penile cancer, potentially paving the way for poly ADP-ribose polymerase inhibitor therapy.

Case presentation
We report a 65-year-old male with PSCC who progressed to thigh metastasis at 10 months after partial penectomy. Next-generation sequencing showed that the penis primary lesion and metastatic thigh lesion harboured a BRCA2 mutation. Chemotherapy plus immunotherapy was used for treatment, and the thigh metastasis was found to involve no tumour. Progression-free survival (PFS) lasted for 8 months until the appearance of lung metastasis. Afterwards, the patient benefited from second-line therapy of olaparib with pembrolizumab and anlotinib, and his disease was stable for 9 months. The same BRCA2 was identified in the lung biopsy. Given the tumour mutation burden (TMB, 13.97 mutation/Mb), the patient received third-line therapy with nivolumab plus ipilimumab, but PFS only lasted for 3 months, with the appearance of right frontal brain metastasis. Then, the patient was treated with radiation sequential fluzoparib therapy as fourth-line treatment, and the treatment efficacy was evaluated as PR. Currently, this patient is still alive.

Conclusions
This is the first report of penile cancer with BRCA2 mutation, receiving a combination treatment with olaparib and experiencing a benefit for 9 months. This case underscores the pivotal role of BRCA2 in influencing treatment response in PSCC, providing valuable insights into the application of targeted therapies in managing recurrent PSCC with BRCA2 alterations. This elucidation establishes a crucial foundation for further research and clinical considerations in similar cases.
The role of Aquaporins in tumorigenesis: implications for therapeutic development
Authors: Bhattacharjee Arkadyuti , Jana Ankit , Bhattacharjee Swagato , Mitra Sankalan , De Swagata , Alghamdi Badrah S. , Alam Mohammad Zubair , Mahmoud Ahmad Bakur , Al Shareef Zainab , Abdel-Rahman Wael M. , Woon-Khiong Chan , Alexiou Athanasios , Papadakis Marios , Ashraf Ghulam Md 
Published: February 2024

AbstractAquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes. Tumour cells of varying sources express AQPs significantly, especially in malignant tumours with a high propensity for metastasis. New insights into the roles of AQPs in cell migration and proliferation reinforce the notion that AQPs are crucial players in tumour biology. AQPs have recently been shown to be a powerful tool in the fight against pathogenic antibodies and metastatic cell migration, despite the fact that the molecular processes of aquaporins in pathology are not entirely established. In this review, we shall discuss the several ways in which AQPs are expressed in the body, the unique roles they play in tumorigenesis, and the novel therapeutic approaches that could be adopted to treat carcinoma.
A call for change: addressing the implementation strategy using pre exposure Prophylaxis for combating the escalating HIV crisis in Zanzibar’s key populations
Authors: Mshenga Mansour Maulid , Tang Weiming 
Published: February 2024

AbstractThe Integrated Bio-Behavioural Surveillance Survey of 2022–2023 among key populations report from Zanzibar has been released. The prevalence of HIV is estimated to be 21.1%, 11.4%, and 9.3% among Female Sex Workers, Men who have Sex with Men, and People Who Injected Drugs, respectively. This has prompted a closer examination of the factors contributing to this trend, with a particular focus on the low coverage of Pre-Exposure Prophylaxis in these key populations. The current prevalence reported in December 2023 signals a critical turning point that necessitates a reevaluation of the barriers and facilitators of Pre Exposure Prophylaxis intervention to combat the epidemic. It is imperative to acknowledge the severity of the situation and take decisive action to prevent further spread of the virus in the Isles.
Cerebrotendinous Xanthomatosis patients with late diagnosed in single orthopedic clinic: two novel variants in the CYP27A1 gene
Authors: Köroğlu Muhammed , Karakaplan Mustafa , Gündüz Enes , Kesriklioğlu Betül , Ergen Emre , Aslantürk Okan , Özdemir Zeynep Maraş 
Published: February 2024

Abstract
Background
Cerebrotendinous Xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder caused by loss of function variants in the CYP27A1 gene which encodes sterol 27-hydroxylase, on chromosome 2q35. Although the symptoms begin commonly in infancy, CTX diagnosis is often delayed. The aim of this study is to review the orthopedic findings of the disease by providing an overview of the clinical features of the disease. It is to raise awareness of this condition for which early diagnosis and treatment are important.

Methods
We retrospectively evaluated the clinical, laboratory, radiological, and genetic findings of eight patients from four families who were admitted to our Orthopedics and Traumatology Department between 2017 and 2022 due to bilateral Achilles tendon xanthomas, were found to have high cholestanol and CYP27A1 gene mutations.

Results
The mean age of patients was 37, and five of them were male. The mean age at the onset of symptoms was 9.25 years. The mean age of initial diagnosis was 33.75 years. Between symptom onset and clinical diagnosis, an average delay of 24.5 years was observed. All patients had bilateral Achilles tendon xanthoma. Notably, a novel variant (c.670_671delAA) in CYP27A1 gene was identified in three patients who also presented with peripheral neuropathy and bilateral pes cavus. One patient had osteoporosis and four patients had osteopenia. Five patients had a history of bilateral cataracts. Furthermore, three of the patients had early-onset chronic diarrhea and three of the patients had ataxia. Two of the patients had epilepsy and seven of the patients had behavior-personality disorder. All patients had low intelligence, but none of them had cardiac disease.

Conclusion
We present the diagnostic process and clinical features which the largest CTX case series ever reported from single orthopedic clinic. We suggest that patients with normal cholesterol levels presenting with xanthoma being genetically analyzed by testing at their serum cholestanol level, and that all siblings of patients diagnosed with CTX be examined.
Engaging Black youth in depression and suicide prevention treatment within urban schools: study protocol for a randomized controlled pilot
Authors: Lindsey Michael A. , Mufson Laura , Vélez-Grau Carolina , Grogan Tracy , Wilson Damali M. , Reliford Aaron O. , Gunlicks-Stoessel Meredith , Jaccard James 
Published: February 2024

Abstract
Background
Depression continues to be an ongoing threat to adolescent well-being with Black adolescents being particularly vulnerable to greater burdens of depression as well as lower mental health service utilization. Black adolescents are likely to have untreated depression due to social network influences, varied perceptions of services and providers, or self-stigma associated with experiencing depressive symptoms. Furthermore, if or when treatment is initiated, low engagement and early termination are common. To address this gap, a trial is being conducted to preliminarily test the effectiveness of an engagement intervention targeting Black adolescents with depression in school mental health services in New York City.

Methods
A total of 60 Black middle and high school adolescents displaying depressive symptoms are equally randomized (based on school site) to the treatment arms. Both trial arms deliver Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), a time-limited, evidence-based treatment for depression. Additionally, one arm pairs IPT-A with a brief, multi-level engagement intervention, the Making Connections Intervention (MCI), involving adolescents, caregivers, and clinicians. Outcomes of interest are group differences in depression and suicide ideation, adolescent and caregiver engagement, and mental health service use.

Discussion
This trial will serve as an efficacy assessment of the MCI among a sample of Black adolescent students with depressive symptoms. Clinical and implementation results will be used to inform future research to further test the MCI intervention in a larger sample.

Trial registration
Registered by ClinicalTrials.gov on May 3, 2019, identifier: NCT03940508.
TFRC, associated with hypoxia and immune, is a prognostic factor and potential therapeutic target for bladder cancer
Authors: Tang Runhua , Wang Haoran , Liu Jianyong , Song Liuqi , Hou Huimin , Liu Ming , Wang Jianye , Wang Jianlong 
Published: February 2024

Abstract
Background
Bladder cancer is a common malignancy of the urinary system, and the survival rate and recurrence rate of patients with muscular aggressive (MIBC) bladder cancer are not ideal. Hypoxia is a pathological process in which cells acquire special characteristics to adapt to anoxic environment, which can directly affect the proliferation, invasion and immune response of bladder cancer cells. Understanding the exact effects of hypoxia and immune-related genes in BLCA is helpful for early assessment of the prognosis of BLCA. However, the prognostic model of BLCA based on hypoxia and immune-related genes has not been reported.

Purpose
Hypoxia and immune cell have important role in the prognosis of bladder cancer (BLCA). The aim of this study was to investigate whether hypoxia and immune related genes could be a novel tools to predict the overall survival and immunotherapy of BLCA patients.

Methods
First, we downloaded transcriptomic data and clinical information of BLCA patients from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A combined hypoxia and immune signature was then constructed on the basis of the training cohort via least absolute shrinkage and selection operator (LASSO) analysis and validated in test cohort. Afterwards, Kaplan–Meier curves, univariate and multivariate Cox and subgroup analysis were employed to assess the accuracy of our signature. Immune cell infiltration, checkpoint and the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm were used to investigate the immune environment and immunotherapy of BLCA patients. Furthermore, we confirmed the role of TFRC in bladder cancer cell lines T24 and UMUC-3 through cell experiments.

Results
A combined hypoxia and immune signature containing 8 genes were successfully established. High-risk group in both training and test cohorts had significantly poorer OS than low-risk group. Univariate and multivariate Cox analysis indicated our signature could be regarded as an independent prognostic factor. Different checkpoint was differently expressed between two groups, including CTLA4, HAVCR2, LAG3, PD-L1 and PDCD1. TIDE analysis indicated high-risk patients had poor response to immunotherapy and easier to have immune escape. The drug sensitivity analysis showed that high-risk group patients were more potentially sensitive to many drugs. Meanwhile, TFRC could inhibit the proliferation and invasion ability of T24 and UMUC-3 cells.

Conclusion
A combined hypoxia and immune-related gene could be a novel predictive model for OS and immunotherapy estimation of BLCA patients and TFRC could be used as a potential therapeutic target in the future.
From COVID-19 to the war in Ukraine: evidence of a Schumpeterian transformation of food logistics
Authors: Andrés González-Moralejo Silvia 
Published: February 2024

AbstractThis study analyzes the changes that have occurred in food logistics in the three years since the emergence of the COVID-19 pandemic and the one year since the war in Ukraine commenced. Food logistics companies are highly sensitive to demand shocks, energy prices, and staff availability. In this study, “first-hand” information was collected in the Iberian Peninsula, and it showed a process of Schumpeterian transformation. This crisis environment in which food logistics companies have been operating has opened a unique opportunity to renew operating procedures and seek new solutions, products, and markets. Therefore, food logistics companies have developed more effective communication strategies and innovative, profitable, and forward-looking commercial strategies to adapt to the new needs of their clients, applied more efficient transport planning and management methods, implemented new technologies to increase automation and digitization in warehouses, transport platforms, and trucks, and boosted market concentration and investment in infrastructure. Therefore, public authorities and top executives must focus on promoting and facilitating these improvements.
Salivary apelin hormone response and dysfunctional attitudes in adolescents in Türkiye: a relational screening model
Authors: Kirbaş Zila Özlem , Bayraktar Bülent , Aktaş Elif Odabaşi 
Published: February 2024

Abstract
Background
Adolescence is the period in which physical and emotional changes occur through hormones, the individual acquires gender characteristics and prepares for the adult role psychologically and physically. Dysfunctional attitudes are beliefs and attitudes that can lead to depression by causing negative thoughts about oneself, others, and the future.Dysfunctional attitudes negatively affect children’s mental health. Hormones have a significant impact on human behavior and cognitive functions. However, little is known about the role and influence of hormones on dysfunctional attitudes. Apelin is a hormone responsible for controlling emotions by regulating emotional behavior. The level of dysfunctional attitudes is one of the important issues in nursing practice in terms of protecting and improving children’s mental health. However, little is known about the role and impact of hormones on dysfunctional attitudes.This study aimed to examine adolescents’ dysfunctional attitudes and salivary apelin hormone levels in terms of sociodemographic variables.

Methods
The study was conducted in a relational screening model with 151 adolescents aged 9–14 years who were reported to be clinically healthy in Türkiye. Apelin hormone levels were analyzed by ELISA technique in the saliva samples of the participants. In the evaluation of dysfunctional attitudes, the relationship between the score obtained from the dysfunctional attitude scale and salivary hormone levels was evaluated.

Results
In the study, a negative, strong and statistically significant correlation was found between the average salivary apelin hormone level and dysfunctional attitudes of adolescents (p =.000). Mean salivary hormone levels of apelin in adolescent girls and boys were 0.696 (SD 0.052) ng/ml, respectively; while 0.671 (SD 0.047) ng/ml was determined (p =.002), dysfunctional attitudes scale scores were 52.95 (SD 14.43); it was determined as 59.04 (SD 14.22) (p =.006). On the other hand, the highest average salivary apelin hormone level (p =.038). and the lowest level of dysfunctional attitudes were determined in adolescent girls aged 13–14 years (p =.028).

Conclusions
In our study, we found that while the salivary apelin hormone levels of adolescents decreased, their dysfunctional attitudes increased. We found that adolescents’ dysfunctional attitudes decreased with age. In contrast, apelin hormone levels increased with age.