bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partnership Cooperation Agreement between Cooperatives and Private Companies to Improve the Economic Competitiveness of the Community in Pasir Jambu, Bandung, West Java
Authors: Azhar Siregar Hamdan 
Published: January 2024

The partnership agreement between cooperatives and the private sector in Ciwidey Pasir Jambu, Bandung is very important to improve the competitiveness of cooperatives. In addition, the importance of the agreement is to create certainty of the legal relationship between the parties, therefore the law must be able to encourage the parties to work in order to improve the ability of cooperatives to compete, especially in Pasirjambu. The problems in this study are as follows, how to cooperate in partnership between cooperatives and private companies, what are the obstacles in partnerships between cooperatives and private companies in Pasirjambu. While its use in research is as a contribution to cooperatives and private companies in carrying out development, as well as a contribution to ideas for cooperatives and private companies to look for obstacles in partnerships, while the research method carried out, namely normative jurisprudence, considering that this research is legal research, while data, namely secondary, primary and tertiary data, also field data as support. In increasing competitiveness in the form of partnerships without definite legal rules, the relationship between the two parties has regressed and uncertain. The implementation of partnerships, based on legal aspects that can provide justice, with the aim of empowering small businesses, cooperatives in national development, namely equal employment and business opportunities, income equality, growing and improving business capabilities, increasing competitiveness, increasing exports, equitable distribution of business ownership and strengthening the structure of the national economy. Through the national business partnership movement, all development actors together renew their determination to mobilize all potentials and strengths to accelerate the growth rate of a just Indonesian nation. Through this movement, the Indonesian nation is prepared to face the challenges and opportunities that open up in free trade
PENGARUH BRAND IMAGE DAN BRAND TRUST TERHADAP LOYALITAS ANGGOTA
Authors: Al Satria Muhammad Idris , Firmansyah Fani 
Published: January 2024

Loyalitas konsumen adalah faktor penting yang harus dievaluasi dan dipahami oleh perusahaan untuk mempertahankan pelanggan. Bagaimana sebuah perusahaan menghasilkan citra merek adalah salah satu hal yang mendorong orang untuk tetap setia kepada perusahaan. Kepercayaan konsumen terhadap merek merupakan aspek lain yang mempengaruhi loyalitas konsumen. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh brand image dan brand trust terhadap loyalitas konsumen. Penelitian ini menggunakan metode kuantitatif. Populasi dalam penelitian ini adalah anggota KSPPS BMT Peta Tulungagung. Survei digunakan untuk memperoleh data. Purposive sampling digunakan dalam penelitian ini, dengan 167 responden yang merupakan anggota KSPPS BMT Peta Tulungagung. Analisis regresi linier berganda digunakan untuk menganalisis data dalam penelitian ini. Sofware SPSS digunakan untuk menganalisis data. Hasil penelitian menunjukkan pengaruh positif dan signifikan secara parsial dari brand image dan brand trust terhadap loyalitas konsumen. Secara bersamaan, brand image dan brand trust memiliki dampak yang luar biasa pada loyalitas konsumen.
Comparative analysis of functional components in Sakekasu (Sake lees)
Authors: Nishidono Yuto , Misaka Shingen , Maejima Yuko , Shimomura Kenju , Tanaka Ken 
Published: January 2024

Background:Sake lees (Sakekasu), a byproduct of sake production, has been recently attracting attention as a functional food. Sakekasu is rich in nutrients and contains glycerophosphocholine (GPC) and S-adenosylmethionine (SAM), which are well-known functional compounds. The content of these compounds in Sakekasu depends on a variety of factors, including fermentation conditions, especially the method and length of ripening. These differences are reflected prominently in the color of Sakekasu, which becomes darker due to the long ripening period and high drying temperature. Objective: This study aimed to clarify the contents of functional components in Sakekasu with different color tones (i.e., ripening period).Methods:Three types of Sakekasu with different color tones (white, ocher, and brawn) were collected from several breweries. The contents of multiple functional components in their extracts were determined by liquid chromatography coupled to high resolution ion-trap/time-of-flight mass spectrometry.Results: Sakekasu with white color had more abundant GPC, SAM, and fatty acids than those with darker color. However, ethyl glucoside and glyceryl glucosides did not differ significantly by color tone. Furthermore, the Maillard reaction products of sugar and dipeptide were mainly found in dark-colored Sakekasu, and their structures were annotated by tandem mass spectrometry.Conclusions:This study has clarified many functional compounds in Sakekasu in relation to color tone (i.e., ripening period) and highlighted the potential of Sakekasu with white color tone as a functional food.Keywords: Sakekasu, functional components, glycerophosphocholine, S-adenosylmethionine, tandem mass spectrometer
C5 nerve root palsy (without prior cervical decompression) case series: 9 patients with critical delay to presentation
Authors: Silver Jacob , Mancini Michael , Pavano Colin , Bauer Jordan , Barkay Gal , Moss Isaac , Mallozzi Scott 
Published: January 2024

BACKGROUND: Distinguishing between cervical nerve root and intrinsic shoulder pathology can be a difficult task given the overlapping and often coexisting symptoms. OBJECTIVE: The objective of this study was to highlight the often-complicated presentation of these symptoms and the subsequent potential for delay in care regarding this subset of patients. METHODS: A total of 9 patients, managed by one of two different surgeons, were identified with a history of C5 nerve root palsy. A chart review was conducted, and the following information was recorded: presenting complaint, time from symptom onset to diagnosis, time from symptom onset to presentation to a spine surgeon, first specialist seen for symptoms, non-spinal advanced imaging and treatment conducted before diagnosis, preoperative and postoperative exam, time to recovery, and type of surgery. RESULTS: We observed an average time from onset of symptoms to presentation to a spine surgeon to be 31.6 weeks. These patients’ time to full recovery after cervical decompression was 15 weeks. CONCLUSION : We observed a critical delay to presentation in this series of patients with C5 nerve palsy. C5 nerve palsy should remain an elemental part of the differential diagnosis in the setting of any shoulder or neck pain presenting with weakness.
Identification of TNFRSF1A as a potential biomarker for osteosarcoma
Authors: Zhang Yuke , Liu Kai , Wang Jianzhong 
Published: January 2024

BACKGROUND: Osteosarcoma (OS) is a relatively rare malignant bone tumor in teenagers; however, its molecular mechanisms are not yet understood comprehensively. OBJECTIVE: The study aimed to use necroptosis-related genes (NRGs) and their relationships with immune-related genes to construct a prognostic signature for OS. METHODS: TARGET-OS was used as the training dataset, and GSE 16091 and GSE 21257 were used as the validation datasets. Univariate regression, survival analysis, and Kaplan-Meier curves were used to screen for hub genes. The immune-related targets were screened using immune infiltration assays and immune checkpoints. The results were validated using nomogram and decision curve analyses (DCA). RESULTS: Using univariate Cox regression analysis, TNFRSF1A was screened from 14 NRGs as an OS prognostic signature. Functional enrichment was analyzed based on the median expression of TNFRSF1A. The prognosis of the TNFRSF1A low-expression group in the Kaplan-Meier curve was notably worse. Immunohistochemistry analysis showed that the number of activated T cells and tumor purity increased considerably. Furthermore, the immune checkpoint lymphocyte activation gene 3 (LAG-3) is a possible target for intervention. The nomogram accurately predicted 1-, 3-, and 5-year survival rates. DCA validated the model (C [Formula: see text] 0.669). Conclusion: TNFRSF1A can be used to elucidate the potential relationship between the immune microenvironment and NRGs in OS pathogenesis.
Real-World Evaluation of the Feasibility, Acceptability and Safety of a Remote, Self-Management Parkinson’s Disease Care Pathway: A Healthcare Improvement Initiative
Authors: Kehagia Angie A. , Chowienczyk Sarah , Helena van Velthoven Michelle , King Emma , North Tracie , Shenton Deb , Abraham Jane , Langley Joseph , Partridge Rebecca , Ankeny Ursula , Gorst Terry , Edwards Emma , Whipps Sue , Batup Martha , Rideout Jane , Swabey Mat , Inches Jemma , Bentley Sue , Gilbert Georgina , Carroll Camille 
Published: January 2024

Background: There is significant unmet need for effective and efficiently delivered care for people with Parkinson’s disease (PwP). We undertook a service improvement initiative to co-develop and implement a new care pathway, Home Based Care (HBC), based on supported self-management, remote monitoring and the ability to trigger a healthcare contact when needed. Objective: To evaluate feasibility, acceptability and safety of Home Based Care. Methods: We evaluated data from the first 100 patients on HBC for 6 months. Patient monitoring, performed at baseline and 6-monthly, comprised motor (MDS-UPDRS II and accelerometer), non-motor (NMSQ, PDSS-2, HADS) and quality of life (PDQ) measures. Care quality was audited against Parkinson’s UK national audit standards. Process measures captured feasibility. Acceptability was assessed using a mixed-methods approach comprising questionnaires and semi-structured interviews. Results: Between October 2019 and January 2021, 108 PwP were enrolled onto HBC, with data from 100 being available at 6 months. Over 90% of all questionnaires were returned, 97% were complete or had < 3 missing items. Reporting and communications occurred within agreed timeframes. Compared with baseline, after 6m on HBC, PD symptoms were stable; more PwP felt listened to (90% vs. 79%) and able to seek help (79% vs. 68%). HBC met 93% of national audit criteria. Key themes from the interviews included autonomy and empowerment. Conclusions: We have demonstrated acceptability, feasibility and safety of our novel remotely delivered Parkinson’s care pathway. Ensuring scalability will widen its reach and realize its benefits for underserved communities, enabling formal comparisons with standard care and cost-effectiveness evaluation.
Meningkatkan Kualitas Pembelajaran Parasitologi: Keberhasilan Kelas Kolaborasi Praktisi Mengajar dalam Mengembangkan Kompetensi Mahasiswa IKIP Budi Utomo
Authors: Qomariyah Ismi Nurul , Hindun Nurmala 
Published: January 2024

This research explores the potential for a collaborative approach between parasitology practitioners and Budi Utomo Teacher Training and Education Institute (IKIP) students in improving parasitology education. The background of this research arises from the urgent need to develop student competence in understanding the increasingly complex and diverse world of parasitology. The purpose of this study is to identify the effectiveness of collaborative classroom teaching practitioners in increasing students' understanding of the basic concepts of parasitology and developing their practical skills.
This research method involves the development of a collaborative curriculum and the implementation of structured teaching practices involving teachers, practitioners, and students simultaneously. The results showed significant improvements in students' understanding of parasitic nature, life cycles, and control strategies. In addition, direct interaction with practitioners provides deep insight into the practical application of theory in real-world situations.
The study provides strong evidence that collaborative classroom teaching practitioners can enhance the effectiveness of parasitology education, enrich students' learning experiences, and prepare them with skills relevant for industry or future research. These findings provide a foundation for the development of innovative teaching methods in parasitology education and are suggested for adoption in various higher education institutions.
Marketing mix Framework as a Tool to Enhance Women’s Business Viability in Limpopo-South Africa
Authors: Mvunabandi Jean Damascene , Nomala Bomi , Gadzikwa Lawrence 
Published: January 2024

Motivated by lack of empirical research on how the marketing mix (price, place, product promotion, process, packaging, physical evidence, people, programming and partnership) directly or indirectly enhance the women’s business viability and sustainability in South Africa and elsewhere. This research empirically investigated how marketing mix can be used to enhance women’s business viability among 301 registered business owners trained in marketing and participated in the survey and answered details questions focusing on Limpopo province -South Africa. AIDA theory, diffusion of innovation theory and Marketing Mix Theory underpinned the study. Quantitative descriptive survey research strategy was adopted, Robustness analysis was entirely performed using SPSS version 28. The study’s findings were that women’s businesses in Musina and Blouberg in Limpopo province use the 10Ps. The four most used marketing strategies were, price, place promotion and product. The averagely used marketing strategies were: people, packaging, programming, physical evidence and partnership. This study contributes to the current body of knowledge and further contributes to the use of 10Ps marketing mix strategies and framework by women’s businesses. The study’s main implication is that business entities may not achieve their full financial performance potential due to little or no attention to the use of 10Ps marketing mix components and training. This study provides robust recommendations and insights into marketing practices applicable to other business entities globally.
PENGARUH JUMLAH CABANG TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN UBI KAYU (Manihot esculenta Crantz)
Authors: Wahyudi  , Ezward Chairil , Haitami A 
Published: January 2024

Tanaman ubi kayu (Manihot esculenta crantz) merupakan tanaman yang penting bagi negara beriklim tropis termasuk Indonesia. Bahkan tanaman ubi kayu menjadi sumber karbohi­drat utama setelah beras dan jagung. Salah satu permasalahan dalam budidaya tanaman ubi kayu adalah belum diketahui jumlah cabang untuk dipelihara pada saat melakukan budidaya. Penelitian ini memiliki tujuan untuk mengetahui pertumbuhan dan produksi tanaman ubi kayu dengan perlakuan pengaturan jumlah cabang. Penelitian berbentuk percobaan lapangan yang dilakukan di Kebun Percobaan Fakultas Pertanian Universitas Islam Kuantan Singingi. Penelitian dilaksanakan selama 9 bulan menggunakan rancangan acak kelompok non faktorial dengan perlakuan pengaturan jumlah cabang yang terdiri 4 taraf perlakuan, masing-masing perlakuan diulang sebanyak 4 ulangan sehingga diperoleh 16 unit percobaan. Perlakuan yang diberikan adalah dengan memelihara tanaman dengan 1 cabang, 2 cabang, 3 cabang dan 4 cabang. Hasil penelitian ini diuji secara statistik dengan uji F. Berdasarkan hasil penelitian yang telah dilakukan bahwasannya perlakuan jumlah cabang tidak memberikan pengaruh terhadap semua parameter pengamatan, tinggi tanaman (cm), diameter batang (cm), jumlah umbi pertanaman (buah) dan bobot umbi pertanaman (kg).
ANALISIS FAKTOR YANG MEMPENGARUHI PEMANFAATAN POSYANDU REMAJA
Authors: Avelina Yuldensia , Nababan Sudarwati , Anita Delang Margaretha 
Published: January 2024

Tujuan: Penyelenggaraan posyandu remaja diharapkan dapat menjadi wadah untuk memfasilitasi remaja dalam memahami permasalahan kesehatan remaja, menemukan alternatif pemecahan masalah, namun masih ada remaja yang tidak datang ke Posyandu remaja sehingga remaja banyak yang tidak mengetahui tentang kesehatannya. Cakupan pelayanan di posyandu remaja Desa Tebuk tahun 2022 yaitu 18%. Penelitian ini bertujuan untuk menjelaskan analisis faktor yang mempengaruhi remaja dalam pemanfaatan posyandu remaja.
Metode: Penelitian ini menggunakan desain analitik crossectional. Sampel dalam penelitian ini adalah remaja yang mengikuti posyandu remaja di Desa Tebuk, dengan kriteria inklusi: berusia 10-19 tahun dan bertempat tinggal di wilayah kerja posyandu remaja Desa Tebuk . Menggunakan Teknik purposive sampling dengan besar sampel 157 orang. Pengumpulan data menggunakan kuesioner dan buku register kunjungan posyandu remaja. Analisis data menggunakan uji Koefisien Kontingensi.
Hasil: Hasil uji koefisien kontingensi faktor pengetahuan diperoleh nilai p-value 0.000 <α 0.05, hal ini menunjukkan ada pengaruh pengetahuan terhadap pemanfaatan posyandu remaja. Faktor sarana prasarana diperoleh nilai p-value 0.000 < α 0.05 menunjukkan ada pengaruh sarana prasarana terhadap pemanfaatan posyandu remaja. Faktor dukungan teman sebaya diperoleh nilai p-value 0.048 < α 0.05, menunjukkan ada pengaruh dukungan teman sebaya terhadap pemanfaatan posyandu remaja. Faktor dukungan keluarga diperoleh nilai p-value 0.002 < α 0.05, menunjukkan ada pengaruh dukungan keluarga terhadap pemanfaatan posyandu remaja. Faktor peran kader diperoleh nilai p-value 0,000 < α 0.05, menunjukkan ada pengaruh peran kader terhadap pemanfaatan posyandu remaja.
Simpulan: Pihak puskesmas diharapkan untuk memilih kader usia remaja sehingga mereka lebih saling mendukung dalam mengikuti posyandu remaja.
Pengaruh Pemberian Vermikompos dan PGPR terhadap Pertumbuhan dan Kadar Gula Semangka (Citrullus vulgaris)
Authors: Widodo Dido Ari , Santoso Juli , Kusumaningrum Nora Augustien 
Published: January 2024

Tanaman semangka menjadi salah satu komoditas unggulan di Indonesia dan mempunyai daya tarik ekonomis yang tinggi. Upaya peningkatan pertumbuhan dan hasil tanaman terus dilakukan, salah satunya menggunakan vermikompos dan PGPR. Penelitian ini dilakukan untuk memperoleh dosis vermikompos dan konsentrasi PGPR yang tepat guna meningkatkan pertumbuhan serta hasil tanaman semangka. Penelitian menggunakan Rancangan Acak Lengkap (RAL) 2 faktor. Faktor pertama adalah dosis vermikompos terdiri dari 4 perlakuan (0, 100, 150 dan 200 gram vermikompos). Faktor kedua adalah konsentrasi PGPR yang terdiri dari 4 perlakuan (0, 15, 20 dan 25 ml/l air). Hasil penelitian menunjukkan bahwa terjadi interaksi antara dosis vermikompos dengan konsentrasi PGPR terhadap panjang tanaman usia 42 dan 49 HST serta kadar gula buah semangka. Dosis vermikompos (200 gram) secara tunggal berpengaruh nyata terhadap panjang tanaman usia 21, 35 dan 49 HST dan diameter batang usia 14, 21, 28, 35, 42 dan 49 HST.
Nanoemulsion and nanoencapsulation of a hydroethanolic extract of Nettle (Urtica dioica) and Wormwood (Artemisia absinthium): comparison of antibacterial and anticancer activity
Authors: Rahmani Zeinab , Karimi Merat , Saffari Iman , Mirzaei Hamed , Nejati Majid , Sharafati Chaleshtori Reza 
Published: January 2024

Introduction: Nanoemulsion and nanoencapsulation are attractive novel methods that can be used for incorporating active plant extracts in food preparations and pharmaceutical formulations. In the current study, we aimed to investigate the anticancer and antibacterial effects of hydroethanolic extracts of Nettle (NE), Wormwood (WE), and the combination of the two plants (CNWE), as well as their nanoemulsion forms (NN, NW, CNNW) and nanoencapsulation forms (CN, CW, and CCNW).Methods: The morphology and structure of the nanoemulsion and nanoencapsulation preparations were assessed utilizing dynamic light scattering (DLS) along with transmission electron microscopy (TEM). The antibacterial activity of the prepared formulations were assessed by determining minimum inhibitory concentration (MIC), zone of inhibition diameter, minimum bactericidal concentration (MBC), along with biofilm growth inhibition against Salmonaella typhimurium and Klebsiella. pneumoniae. The anticancer activity was evaluated via a MTT assay in the colon cancer cell line (HCT116).Results: The nanoemulsion and nanoencapsulation particle size varied between 10 and 50 nm and 60 and 110 nm, respectively. The MIC values were between 11.25 and 95 µg/mL along with MBC values between 11.25 and 190 µg/mL. The highest inhibition of biofilm formation was observed with CCNW against K. pneumoniae (∼78.5%) and S. typhimurium (∼73%). In descending order, the inhibition of biofilm formation was CCNW &gt; CW &gt; CN &gt; CNNW &gt; NN &gt; NW &gt; CNWE &gt; NE &gt; WE against the tested bacteria. The IC50 values for NE, WE, CNWE, NN, NW, CNNW, CN, CW, and CCNW were determined as 250, 170, 560, 380, 312, 370, 250, 420, and 700 µg/mL, respectively. Exposure to a high concentration of NW resulted in a significantly lower HCT116 viability compared to other groups. Taken together, CNNW, and CCNW showed the highest antibacterial and anticancer activitiy.Discussion: Nanoemulsion and nanoencapsulation were effective ways to increase the antibacterial and anticancer activity of the extracts and could be used in the food and pharmaceutical industries.
Clinical predictors of left ventricular thrombus after myocardial infarction as detected by magnetic resonance imaging
Authors: Fardman Alexander , Massalha Eias , Natanzon Sharon Shalom , Brodov Yafim , Goitein Orly , Chernomordik Fernando , Herscovici Romana , Grupper Avishay , Kuperstein Rafael , Mazin Israel , Matetzky Shlomi , Beigel Roy 
Published: January 2024

BackgroundThe diagnosis of a left ventricular (LV) thrombus in patients with ST-segment elevation myocardial infarction (STEMI) remains challenging. The aim of the current study is to characterize clinical predictors for LV thrombus formation, as detected by cardiac magnetic resonance imaging (CMRI).MethodsWe retrospectively evaluated 337 consecutive STEMI patients. All patients underwent transthoracic echocardiography (TTE) and CMRI during their index hospitalization. We developed a novel risk stratification model (ThrombScore) to identify patients at risk of developing an LV thrombus.ResultsCMRI revealed the presence of LV thrombus in 34 patients (10%), of whom 33 (97%) had experienced an anterior wall myocardial infarction (MI), and the majority (77%) had at least mildly reduced left ventricular ejection fraction (LVEF &lt; 45%). The sensitivity for thrombus formation of the first and second TTE was 5.9% and 59%, respectively. Multivariate logistic regression model revealed that elevated C-reactive protein levels, lack of ST-segment elevation (STe) resolution, elevated creatine phosphokinase levels, and STe in anterior ECG leads are robust independent predictors for developing an LV thrombus. These variables were incorporated to construct the ThrombScore: a simple six-point risk model. The odds ratio for developing thrombus per one-point increase in the score was 3.2 (95% CI 2.1–5.01; p &lt; 0.001). The discrimination analysis of the model revealed a c-statistic of 0.86 for thrombus development. The model identified three distinct categories (I, II, and III) with corresponding thrombus incidences of 0%, 1.6%, and 27.6%, respectively.ConclusionThrombScore is a simple and practical clinical model for risk stratification of thrombus formation in patients with STEMI.