bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sunitinib in Patients With Breast Cancer With FGFR1 or FGFR2 Amplifications or Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study
Authors: Calfa Carmen J. , Rothe Michael , Mangat Pam K. , Garrett-Mayer Elizabeth , Ahn Eugene R. , Burness Monika L. , Gogineni Keerthi , Rohatgi Nitin , Al Baghdadi Tareq , Conlin Alison , Gaba Anu , Hamid Omid , Krishnamurthy Jairam , Gavini Naga Jyothi , Gold Philip J. , Rodon Jordi , Rueter Jens , Thota Ramya , Grantham Gina N. , Hinshaw Dominique C. , Gregory Abigail , Halabi Susan , Schilsky Richard L. 
Published: February 2024

PURPOSE The Targeted Agent and Profiling Utilization Registry Study is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer and genomic alterations known to be drug targets. Results from cohorts of patients with metastatic breast cancer (BC) with FGFR1 and FGFR2 alterations treated with sunitinib are reported. METHODS Eligible patients had measurable disease, Eastern Cooperative Oncology Group performance status 0-2, adequate organ function, and no standard treatment options. Simon's two-stage design was used with a primary end point of disease control (DC), defined as objective response (OR) or stable disease of at least 16 weeks duration (SD16+) according to RECIST v1.1. Secondary end points included OR, progression-free survival, overall survival, duration of response, duration of stable disease, and safety. RESULTS Forty patients with BC with FGFR1 (N = 30; amplification only n = 26, mutation only n = 1, both n = 3) or FGFR2 (N = 10; amplification only n = 2, mutation only n = 6, both n = 2) alterations were enrolled. Three patients in the FGFR1 cohort were not evaluable for efficacy; all patients in the FGFR2 cohort were evaluable. For the FGFR1 cohort, two patients with partial response and four with SD16+ were observed for DC and OR rates of 27% (90% CI, 13 to 100) and 7% (95% CI, 1 to 24), respectively. The null hypothesis of 15% DC rate was not rejected ( P = .169). No patients achieved DC in the FGFR2 cohort ( P = 1.00). Thirteen of the 40 total patients across both cohorts had at least one grade 3-4 adverse event or serious adverse event at least possibly related to sunitinib. CONCLUSION Sunitinib did not meet prespecified criteria to declare a signal of antitumor activity in patients with BC with either FGFR1 or FGFR2 alterations. Other treatments and clinical trials should be considered for these patient populations.
Height Restoration for Vertebra Plana Using a Mechanical Lamellar Vertebral Body Reduction Device: 2-Dimensional Operative Video
Authors: Ramadani Fatos , Valsecchi Daniele , Goga Cristina , Otten Philippe , Maestretti Gianluca 
Published: February 2024

Compression fractures of thoracolumbar vertebra are the most common vertebral fracture.
1
Associated with osteoporosis, the compression can progress until reach vertebra plana and cause a kyphosis.
2
The reduction of the fresh fracture and restoration of the height are the purposes of the kyphoplasty.
3
We present a modified technique adapted for the treatment of vertebral plana using a mechanical flexible lamellar vertebral body reduction device (Tektona, Spinart).
4

We present the case of a 77-year-old woman with back pain after a fall. The radiological investigations show a compressive fracture type AO A1 of T7. After an initial conservative management, the patient presented persistence of the pain with a visual analog scale of 9/10 and progression of the fracture at the 2-week follow-up. On the x-ray, focal kyphosis with vertebra plana was observed. A kyphoplasty for pain management and kyphosis correction was performed. The patient consented to the procedure.
A bipedicular approach to the vertebra was performed. The correction of the height was done using 2 mechanical devices. The lamellar device allowed a progressive height restoration of the fracture. On one side, the cannula was used as a support to maintain the correction during the contralateral cementing. The postoperative imaging confirmed a maintained vertebral restoration with kyphosis correction. At 1 year, the patient reported a pain at 1 of 10 on the visual analog scale.
In our opinion, this technique is adapted for fresh osteoporotic vertebral compression fractures. Surgical experience in osteoporotic fracture treatment and kyphoplasty is recommended before the management of vertebra plana.
Nutrition Strategies for Optimizing Performance and Health in Young Athletes
Authors: Woźniak Kinga , Hedesz Patryk , Żuk-Łapan Aleksandra , Jung Magdalena , Gardian-Baj Monika , Popczyńska Justyna , Doryń Aleksandra , Jung Maximilian , Babula Emilia , Włodarczyk Aleksandra , Taras Andrzej 
Published: February 2024

Introduction: The increasing participation of young individuals in sports necessitates a comprehensive understanding of the intricate relationship between nutrition and athletic performance during the critical adolescent years. This introduction sets the stage for an exploration of the dynamic nutritional needs of young athletes, emphasizing the pivotal role of nutrition in supporting growth, energy metabolism, and overall athletic achievement.
Current State of Knowledge: The current state of knowledge encompasses an in-depth analysis of key nutritional considerations for young athletes. Examining energy and macronutrient requirements, micronutrient considerations, hydration strategies, and optimal timing of nutrition, this section synthesizes existing research to provide evidence-based guidelines. Furthermore, it addresses the unique challenges posed by different sports and the importance of tailored nutritional approaches for diverse athletic endeavors. The evolving landscape of sports nutrition is also explored, with a specific focus on the benefits and potential risks associated with protein and creatine supplementation.
Summary: In summary, this article serves as a comprehensive resource for athletes, coaches, and parents seeking to navigate the intricate intersection of nutrition and young athletes. By elucidating evidence-based strategies and addressing the potential drawbacks and risks associated with certain supplements, the article aims to empower stakeholders with the knowledge needed to make informed decisions regarding the nutritional well-being of young athletes. It underscores the importance of individualized approaches, recognizing the diversity of young athletes and advocating for adaptable nutritional strategies that contribute to both immediate performance gains and sustained health and athletic success.
Mathematical Programming-Driven Daily Berth Planning in Xiamen Port
Authors: Zhen Lu , Li Haolin , Xiao Liyang , Lin Dayu , Wang Shuaian 
Published: February 2024

In this paper, we introduce the daily berth planning problem for Xiamen Hai-Tian Container Terminal (XHCT) at the Port of Xiamen, China, and propose the development and implementation of a berth planning system. The aim of the berth planning problem is to optimize daily berth plans by considering various decisions, including berth allocation, quay crane assignment, fairway traffic control, and berthing safety requirements. Among these decisions, the berthing safety requirement is a novel but practical problem in berth allocation that concerns the resource allocation related to berthing safety and interrelation with other decisions. A mathematical programming-driven methodological framework is designed with a 0-1 integer linear programming model for problem formulation and a highly efficient decomposition heuristic algorithm for solving the problem. This framework establishes the core for the berth planning system. The adoption of the berth planning system contributes to the increase of container throughput and berth capacity by transforming the planning process of XHCT. Moreover, the mathematical programming-driven daily berth planning informs further intelligent operations development in the Port of Xiamen and other container ports. History: This paper was refereed. Funding: This research was supported by the National Natural Science Foundation of China [Grants 72394360, 72394362, 72025103, 71831008, 72361137001, 72071173, and 72371221].
Combinatorial Optimization-Enriched Machine Learning to Solve the Dynamic Vehicle Routing Problem with Time Windows
Authors: Baty Léo , Jungel Kai , Klein Patrick S. , Parmentier Axel , Schiffer Maximilian 
Published: February 2024

With the rise of e-commerce and increasing customer requirements, logistics service providers face a new complexity in their daily planning, mainly due to efficiently handling same-day deliveries. Existing multistage stochastic optimization approaches that allow solving the underlying dynamic vehicle routing problem either are computationally too expensive for an application in online settings or—in the case of reinforcement learning—struggle to perform well on high-dimensional combinatorial problems. To mitigate these drawbacks, we propose a novel machine learning pipeline that incorporates a combinatorial optimization layer. We apply this general pipeline to a dynamic vehicle routing problem with dispatching waves, which was recently promoted in the EURO Meets NeurIPS Vehicle Routing Competition at NeurIPS 2022. Our methodology ranked first in this competition, outperforming all other approaches in solving the proposed dynamic vehicle routing problem. With this work, we provide a comprehensive numerical study that further highlights the efficacy and benefits of the proposed pipeline beyond the results achieved in the competition, for example, by showcasing the robustness of the encoded policy against unseen instances and scenarios. History: This paper has been accepted for the Transportation Science special issue on DIMACS Implementation Challenge: Vehicle Routing Problems. Funding: This work was supported by Deutsche Forschungsgemeinschaft [Grant 449261765].
A study of the impact of an interprofessional education module in Vietnam on students’ readiness and competencies
Authors: Nguyen Huyen Thi Thanh , Wens Johan , Tsakitzidis Giannoula , Valcke Martin , Nguyen Hoa Thi , Duong Tuan Quang , Nguyen Cuc Thi , Hoang Dao Anh , Hoang Yen Thi Bach , Duong Lan Thi Ngoc , Nguyen Hung Van , Truong Thanh Viet , Nguyen Huy Vu Quoc , Nguyen Tam Minh 
Published: February 2024

Introduction
The literature puts forward a range of challenges of interprofessional education (IPE) related to its planning, initiation, implementation, and especially to IPE assessment. The present study aims to map changes in students’ readiness and interprofessional collaboration competence (IPCC) in implementing an innovative IPE module. Potential differences in impact related to the health education programs and IPCC scores resulting from self-, peer-, and tutor assessments will also be analysed.

Methods
A pre-post design was adopted. The student’s readiness for interprofessional learning was assessed using the Readiness for Interprofessional Learning Scale, and the student’s IPCC score was calculated based on self-, peer-, and tutor assessments with the interprofessional collaborator assessment rubric.

Results
Students’ mean post-test readiness scores and mean post-test IPCC scores were significantly higher than the total and subscales/domain pre-test scores (p<0.01). No significant within-subject differences were observed in students’ readiness total or subscale scores when comparing health educational programs. However, significant differences were observed in students’ mean total IPCC scores between programs (p<0.01). Significant differences in students’ average IPCC scores were found when comparing self-, peer- and tutor assessment scores in six domains (p<0.01). Also, significant correlations between peer and tutor assessment scores were observed (p<0.01).

Conclusion
The IPE module, designed and implemented to focus on patient-centred practice within a primary care context, positively impacted students’ readiness and IPCC development. These results offer insights to expand the implementation of the IPE module to all health educational programs.
Association of dietary carbohydrate and fiber ratio with postmenopausal bone mineral density and prevalence of osteoporosis: A cross-sectional study
Authors: Zhang Lushuang , Zhao Liubiqi , Xiao Xinyu , Zhang Xiaobin , He Li , Zhang Qiang 
Published: February 2024

Background
This study aimed to investigate the associations of carbohydrate to dietary fiber ratio with bone mineral density (BMD) and the prevalence of osteoporosis in postmenopausal women.

Methods
This cross-sectional study retrieved the data of 2829 postmenopausal women from the National Health and Nutrition Examination Survey (NHANES) database. Weighted univariable logistic regression models were used to investigate the correlations of carbohydrate, dietary fiber, or carbohydrate to fiber ratio with osteoporosis.

Results
Higher dietary fiber intake was correlated with decreased odds ratio of osteoporosis [odds ratio(OR) = 0.96, 95% confidence interval (CI): 0.93 to 0.99]. The odds ratio of osteoporosis in postmenopausal women was elevated as the increase of carbohydrate to fiber ratio (OR = 1.80, 95%CI: 1.10 to 2.96). Carbohydrate to fiber ratio >17.09 was related to increased odds ratio of osteoporosis (OR = 1.63, 95%CI: 1.04 to 2.56). Compared to the carbohydrate to fiber ratio ≤11.59 group, carbohydrate to fiber ratio >17.09 was associated with decreased total femur BMD (β = -0.015, 95%CI: -0.028 to -0.001) and femur neck BMD (β = -0.020, 95%CI: -0.033 to -0.006) in postmenopausal women. The femur neck BMD in postmenopausal women was decreased with the increase of carbohydrate to fiber ratio (β = -0.015, 95%CI: -0.028 to -0.001).

Conclusion
In postmenopausal women, a high carbohydrate/fiber ratio >17.09 is associated with an increased risk of osteoporosis and lower hip BMD and high fiber intake is associated with less osteoporosis and higher hip BMD.
SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells
Authors: Tian Ping , Du Dajun , Yang Li , Zhou Nan , Tao Ling 
Published: February 2024

Background
Timeless is well-known for its key role in replication checkpoints. Recent studies reveal the involvement of Timeless and specificity protein (SP) 1 in human malignancies. However, no evidence proved the interaction between SP3 and Timeless in lung adenocarcinoma (LUAD).

Methods
The expression and clinical significance of Timeless were analyzed using the LUAD dataset downloaded from the Cancer Genome Atlas (TCGA). Lentivirus-mediated Timeless knockdown in A549 cells was used to examine the role of Timeless in cell proliferation and pemetrexed (PEM) resistance. Transcription factors (TFs) bound to the Timeless promoter were identified by DNA pull-down technology with HPLC-MS/MS analysis and analyzed by the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Dual-luciferase reporter assay was used to determine the activity of SP3 in Timeless transcription.

Results
Timeless was overexpressed in LUAD samples, and it could serve as a potential diagnostic or prognostic biomarker for LUAD patients. shTimeless-mediated knockdown of Timeless reduced cell viability and proliferation and sensitized PEM-resistant A549 cells to PEM. Four fragments (F1: 1–373 bp), (F2: 374–962 bp), (F4: 1274–1645 bp), and (F5: 1646-2000bp) were confirmed as the TF binding profiles of the Timeless promoter. KEGG analysis showed that the TFs bound to the Timeless promoter had relevance to spliceosome, RNA transport, and mRNA surveillance pathways. SP3 promoted the transcription of Timeless via the F2 fragment (374–962 bp) binding motif.

Conclusion
Upregulation of Timeless mediated by SP3 promotes LUAD cell proliferation, providing evidence to support that targeting the SP3/Timeless axis may be a potential therapeutic strategy against LUAD.
Like a Prisoner: Stories of Endurance (Trans. J. Hodgson), Fatos Lubonja (2022)
Authors: Lambert Zoe 
Published: February 2024

Review of: Like a Prisoner: Stories of Endurance (Trans. J. Hodgson), Fatos Lubonja (2022)
London: Istros Books, 180 pp.,
ISBN 978-1-91254-585-8, p/bk, £9.99
The Writer’s Torch: Reading Stories from The Bell, Phyllis Boumans, Elke D’hoker and Declan Meade (eds) (2023)
Authors: Rutter John D. 
Published: February 2024

Review of: The Writer’s Torch: Reading Stories from The Bell, Phyllis Boumans, Elke D’hoker and Declan Meade (eds) (2023)
Dublin: The Stinging Fly Press, 329 pp.,
ISBN 978-1-90653-991-7, p/bk, £17.99
Detection of giant cytoplasmic inclusions in a pediatric patient with recurrent infections: a case report
Authors: Saiz-Sierra Leire , Marull Arnall Anna , Nieto-Moragas Javier , Deulofeu Meritxell , Jiménez Romero Orlando , Mademont Irene , Obón Ferrer María , Serrando Querol María Teresa 
Published: February 2024

Abstract

Objectives
Giant inclusions in leukocytes is a common feature that can be observed in some infections but can be also related to rare genetic disorders such as Chédiak-Higashi syndrome (CHS). A differential diagnosis between these groups of diseases has to be performed using specific genetic tests. Clinical and pathological history is relevant for a diagnostic orientation due to the difficulty and specificity of the diagnostic confirmation.

Case presenation
We present the case of a 3-years-old male patient with recurrent respiratory infections. It is important to highlight the presence of a lock of white hair on the front of the head and some hypopigmentation of the skin. In the blood smear, the presence of big cytoplasm granules in all the leukocytes, especially in neutrophils.

Conclusions
CHS is an uncommon genetic disorder caused by the mutation in the LYST gene situated in chromosome 1q42.3 which codified for LYST protein. Molecular genetic testing also can be done to detect the biallelic variants in the LYST gene. It is essential to perform peripheral blood smears in the presence of changes in quantitative and/or qualitative values in the complete blood count as a first step in the diagnosis algorithm.
Biomarcadores séricos para la evaluación de la fibrosis hepática
Authors: Maroto-García Julia , Moreno-Álvarez Ana , Sanz de Pedro María P. , Buño-Soto Antonio , González Álvaro 
Published: February 2024

Resumen
La fibrosis hepática se desarrolla como respuesta a la presencia de daño hepático crónico de diferentes etiologías, provocando un desequilibrio entre la síntesis y degeneración de la matriz extracelular y la desregulación de diversos mecanismos fisiológicos. En los estadios iniciales de las patologías crónicas, el hígado posee una elevada capacidad de regeneración, por lo que la detección temprana de la fibrosis hepática resulta esencial. En este contexto, es preciso contar con herramientas sencillas y económicas que permitan detectar la fibrosis hepática en sus fases iniciales. Para evaluar la fibrosis hepática, se han propuesto multitud de biomarcadores séricos no invasivos, tanto directos, como el ácido hialurónico o las metaloproteasas, como indirectos. Así mismo, se han desarrollado diversas fórmulas que combinan dichos biomarcadores junto con parámetros demográficos, como el índice FIB-4, el índice de fibrosis en la enfermedad de hígado graso no alcohólico (NFS, por sus siglas en inglés), la prueba ELF o el score de fibrosis Hepamet (HFS, por sus siglas en inglés). En el presente manuscrito, realizamos una revisión crítica del valor diagnóstico y pronóstico de los diferentes biomarcadores séricos y fórmulas actualmente existentes.
Incidental vocabulary learning from listening, reading, and viewing captioned videos: frequency and prior vocabulary knowledge
Authors: Teng Mark Feng 
Published: February 2024

Abstract
The present study, given increasing attention to incidental vocabulary learning, explores how different input modes (i.e., listening, reading, and viewing captioned videos) affect such learning while considering frequency and prior vocabulary knowledge. One hundred twenty Chinese university students learning English as a foreign language were allocated to three treatment groups and one (test-only) control group. Target words included 48 terms appearing at various frequencies (1–6 occurrences) in a documentary video. Incidental vocabulary learning outcomes were measured through form and meaning recognition. Mixed effects models showed that the caption viewing condition led to the most pronounced incidental vocabulary learning and retention outcomes, followed by the reading and listening conditions. A significant interaction effect was identified between time, group, and prior vocabulary knowledge. A significant interaction effect was also observed between time, group, and frequency. Meanwhile, frequency was less important for incidental vocabulary learning than prior vocabulary knowledge. Pedagogical implications are discussed based on these findings.
Facemask comfort enhancement with graphene oxide from recovered carbon waste tyres
Authors: Aziz Ungku Nur Ainaa Ungku Mohd , Nor Affandi Nor Dalila , Harun Ahmad Mukifza , Rahman Mohd Azizi Abdul , Indrie Liliana , Bonnia Noor Najmi 
Published: February 2024

Abstract
Commercial disposable facemasks have lower breathability and may cause discomfort after hours of wearing them. Graphene oxide (GO) nanoparticles offer a significant opportunity to improve the breathability of facemask materials. Hence, the current study aimed to investigate the feasibility of incorporating GO in facemask materials. The GO was synthesized from recovered carbon of waste carbon tyre. In this study, two concentrations of GO (0.01 and 0.02%) were used to enhance the comfort properties of the polypropylene (PP) facemask fabric. The GO-coated PP facemask fabrics were characterized for scanning electron microscopy, energy dispersive X-ray, and Raman spectroscopy. The comfort properties were determined using air permeability, water vapour permeability, and moisture management test. Raman analysis revealed distinctive peaks corresponding to GO at approximately 1,300 and 1,500 cm−1. The GO displayed bumping pieces of particles and a textured surface, with a diameter ranging from 30 to 80 nm. The result of mercury porosimetry shows that the PP fabric coated with 0.02% of GO provided a higher pore diameter and porosity at approximately 21.31 µm and 82.79%, respectively. Due to its high pore diameter and porosity, the PP filter facemask fabric coated with 0.02% GO demonstrated enhanced air permeability, water vapour permeability, and moisture management. These results suggested that the sample possesses favourable breathability properties as compared to the sample without GO. By undertaking this study, GO synthesized from the waste carbon tyre was developed, which can enhance the breathability of fabric materials.