bluuebunny/crossref_metadata_2025_split huggingface dataset:
A decade of digital maturity models: much ado about nothing?
Authors: Thordsen Tristan , Bick Markus 
Published: October 2023

AbstractThe topic of digital maturity has evolved into a full-grown hype in the last decade. It is widely assumed that the level of an organization’s digital maturity is directly linked to its performance. Digital Maturity Models (DMMs) have been designed specifically to assess an organization’s digital status quo and to provide concrete measures to increase its level of digital maturity. Given this relevance, a multitude of these models have emerged. Still, the development and application of DMMs is controversially discussed within the academic community leading to great uncertainty regarding their value for both theory and practice. In this systematic literature review, we seek to paint a comprehensive picture of the research field by identifying and contrasting the main contentious opinions among IS scholars. An analysis of detailed information regarding the research area – encompassing extensive DMM literature, academic discussion, and feedback – shows that various critical voices question the actual practical and theoretical value of DMMs, underlining the absence of objective evaluation criteria of these models and pointing out the lack of empirical data to prove the suggested relationship between maturity and performance. Based on our experience in this field, we provide a first synthesis of eleven years of DMMs and derive a research agenda.
Osteogenic potential of apical papilla stem cells mediated by platelet-rich fibrin and low-level laser
Authors: Ramírez David Gutiérrez , Inostroza Carolina , Rouabhia Mahmoud , Rodriguez Camilo Alfonso , Gómez Lina Andrea , Losada Mónica , Muñoz Ana Luisa 
Published: October 2023

AbstractTo evaluate the osteogenic potential of platelet-rich fibrin (PRF) and low-level laser therapy (LLLT) on human stem cells from the apical papilla (SCAP) we isolated, characterized, and then cultured in an osteogenic medium cells with PRF and/or LLLT (660 nm, 6 J/m2-irradiation). Osteogenic differentiation was assessed by bone nodule formation and expression of bone morphogenetic proteins (BMP-2 and BMP-4), whereas the molecular mechanisms were achieved by qRT-PCR and RNA-seq analysis. Statistical analysis was performed by ANOVA and Tukey’s post hoc tests (p < 0.05* and p < 0.01**). Although PRF and LLLT increased bone nodule formation after 7 days and peaked at 21 days, the combination of PRF + LLLT led to the uppermost nodule formation. This was supported by increased levels of BMP-2 and -4 osteogenic proteins (p < 0.005). Furthermore, the PRF + LLLT relative expression of specific genes involved in osteogenesis, such as osteocalcin, was 2.4- (p = 0.03) and 28.3- (p = 0.001) fold higher compared to the PRF and LLLT groups, and osteopontin was 22.9- and 1.23-fold higher, respectively (p < 0.05), after 7 days of interaction. The transcriptomic profile revealed that the combination of PRF + LLLT induces MSX1, TGFB1, and SMAD1 expression, after 21 days of osteogenic differentiation conditions exposition. More studies are required to understand the complete cellular and molecular mechanisms of PRF plus LLLT on stem cells. Overall, we demonstrated for the first time that the combination of PRF and LLLT would be an excellent therapeutic tool that can be employed for dental, oral, and craniofacial repair and other tissue engineering applications.
Variability of cardioinhibition in vasovagal syncope: differences between subgroups during cardioinhibition and beyond
Authors: van Rossum Ineke A. , de Lange Frederik J. , Benditt David G. , van Zwet Erik W. , van Houwelingen Marc , Thijs Roland D. , van Dijk J. Gert 
Published: October 2023

Abstract
Purpose
We compared hemodynamic parameters between subjects with marked, intermediate and minimal cardioinhibition during vasovagal syncope.

Methods
The study included subjects with a decrease in heart rate while experiencing a complete vasovagal syncope during tilt-table testing. The subjects were classified as having marked, intermediate or minimal cardioinhibition, based on tertile values of the decrease in heart rate. Hemodynamic parameters between these groups were compared before tilt in the supine position, shortly after tilt and during cardioinhibition.

Results
A total of 149 subjects with a median age of 43 (interquartile range 24–60) years were included in the study. Among the three groups with different levels of cardioinhibition, the highest heart rate was observed in subjects with marked cardioinhibition both before and shortly after tilt and at the start of cardioinhibition. The heart rate decrease in these subjects was both larger and faster compared to subjects with minimal and intermediate cardioinhibition.

Conclusion
Subjects with marked cardioinhibition have both a larger and faster decrease in heart rate compared to subjects with intermediate and minimal cardioinhibition, as early as from the start of cardioinhibition. Marked cardioinhibition is related to differences in hemodynamic profiles already present well before the start of cardioinhibition.
An analysis of the effectiveness of rehabilitation protocols for patients with spinal cord injury: A systematic review
Authors: Lee Kyung Eun , Jeoung Bogja 
Published: October 2023

Abstract
Aim
SCI may cause loss of sensory function, paralysis, and limited functional mobility. The specificity of SCI has expanded the scope of medical trials and given rise to therapeutic options that incorporate new technologies with robotics and electronic devices. We aimed to identify various therapeutic options and develop effective treatment regimens.

Methods
We conducted the systematic review using the following digital databases: MEDLINE/PubMed and Google Scholar. We focused on publications published between 2012 and 2023 and The following primary terms were searched: “Spinal cord injury rehabilitation,” “Spinal cord injury exercise,” and “Spinal cord injury therapy,” with the Boolean operator “AND/OR” used for additional searches. A total of 110 relevant articles were identified during the selection process. After screening and assessing eligibility, the final 17 studies were included in this systematic review

Results & conclusion
The current paper gave a taxonomy of electrical instrumentation and traditional rehabilitation technologies. We also discovered that FES is used as a comprehensive regimen that involves both the upper and lower extremities, and that locomotor training using robots is beneficial in improving walking ability. We discovered that diversified training programs using conventional methods concentrated on the physical independence of patients with chronic SCI.
Characterization of breast changes in the early gestational period on automated breast ultrasound
Authors: Ohta Tomoyuki 
Published: October 2023

Abstract
Purpose
This study was conducted to determine the characteristics of milk duct development in early pregnancy on ultrasound images.

Methods
Automated breast ultrasound (ABUS) images used for breast cancer screening in 332 pregnant women were evaluated retrospectively to determine when and how ductal development becomes evident on ultrasonography. The diagnostic criteria used for mammary gland changes during the gestational period were extension of the ducts to the margins of the breast where little or no echogenic fibroglandular tissue is seen on sonograms and/or the appearance of ductal structures running along the ascending Cooper’s ligament tapering off or ending in a blind end at the superficial layer of the superficial fascia. The correlations between gestational stage and the prevalence of these criteria were verified by Spearman’s rank correlation coefficient (ρ). Assessments were performed by a single radiologist with experience reading ABUS images.

Results
With a few exceptions, the prevalence of the above findings increased sharply beginning at 10 weeks, and then increased with progression of gestation, reaching a plateau after 20 weeks (ρ = 0.766, P < 0.00001).

Conclusion
The findings in this study suggested that development of the milk ducts in early pregnancy can be observed using ABUS. These findings will be useful to gain a better understanding of breast ultrasound imaging characteristics during pregnancy.
Quantitative assessment of human health risks from chemical pollution in the uMsunduzi River, South Africa
Authors: Ngubane Zesizwe , Dzwairo Bloodless , Moodley Brenda , Stenström Thor Axel , Sokolova Ekaterina 
Published: October 2023

AbstractA quantitative chemical risk assessment was performed using published data as well as data from the official monitoring programme for the uMsunduzi River in KwaZulu-Natal, South Africa. The chemicals assessed were organochlorinated pesticides (OCPs), pharmaceuticals and personal care products (PPCPs), heavy metals, and nitrates and phosphates. The water from uMsunduzi River is used locally without treatment. Consequently, the exposure routes investigated were via ingestion during domestic drinking and incidental ingestion during recreational activities, which were swimming and non-competitive canoeing, for both adults and children. For the individual chemicals, non-carcinogenic risks using the hazard quotient (HQ) and carcinogenic risks using the cancer risk (CR) were quantified. It was found that the exposed population is likely to experience non-carcinogenic effects from pesticides and phosphates, but not from PPCPs, heavy metals and nitrates. This study also found that the carcinogenic risks for OCPs were higher than the tolerable limit of 10-5, while for lead the risk was below the tolerable limit. Some of the activities that potentially contribute to chemicals onto the uMsunduzi River are subsistence farming, small plantations, illegal dumping, industries, and broken sewers. The findings of this study may act as the technical foundation for the introduction of pollution reduction measures within the catchment, including public education.
Graphical Abstract
Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
Authors: Nolt Georgia L. , Keeble Alexander R. , Wen Yuan , Strong Aubrey C. , Thomas Nicholas T. , Valentino Taylor R. , Brightwell Camille R. , Murach Kevin A. , Patrizia Sini , Weinstabl Harald , Gollner Andreas , McCarthy John J. , Fry Christopher S. , Franti Michael , Filareto Antonio , Peterson Charlotte A. , Dungan Cory M. 
Published: October 2023

AbstractSkeletal muscle adaptation to external stimuli, such as regeneration following injury and hypertrophy in response to resistance exercise, are blunted with advanced age. The accumulation of senescent cells, along with defects in myogenic progenitor cell (MPC) proliferation, have been strongly linked as contributing factors to age-associated impairment in muscle adaptation. p53 plays an integral role in all these processes, as upregulation of p53 causes apoptosis in senescent cells and prevents mitotic catastrophe in MPCs from old mice. The goal of this study was to determine if a novel pharmaceutical agent (BI01), which functions by upregulating p53 through inhibition of binding to MDM2, the primary p53 regulatory protein, improves muscle regeneration and hypertrophy in old mice. BI01 effectively reduced the number of senescent cells in vitro but had no effect on MPC survival or proliferation at a comparable dose. Following repeated oral gavage with 2 mg/kg of BI01 (OS) or vehicle (OV), old mice (24 months) underwent unilateral BaCl2 injury in the tibialis anterior (TA) muscle, with PBS injections serving as controls. After 7 days, satellite cell number was higher in the TA of OS compared to OV mice, as was the expression of genes involved in ATP production. By 35 days, old mice treated with BI01 displayed reduced senescent cell burden, enhanced regeneration (higher muscle mass and fiber cross-sectional area) and restoration of muscle function relative to OV mice. To examine the impact of 2 mg/kg BI01 on muscle hypertrophy, the plantaris muscle was subjected to 28 days of mechanical overload (MOV) in OS and OV mice. In response to MOV, OS mice had larger plantaris muscles and muscle fibers than OV mice, particularly type 2b + x fibers, associated with reduced senescent cells. Together our data show that BI01 is an effective senolytic agent that may also augment muscle metabolism to enhance muscle regeneration and hypertrophy in old mice.
Application of Situational Action Theory in Japan Using Vignette Survey
Authors: Fujino Kyoko 
Published: October 2023

AbstractThis study applied Wikström’s Situational Action Theory (SAT) of crime causation to Japanese people in their 30 s–40 s (N = 320). Participants in an internet survey were presented with three criminogenic scenarios—traffic crime, individualistic white-collar crime, and corporate white-collar crime—and were asked to rate the likelihood of them committing a crime in these scenarios. They were also asked to evaluate their morality, moral context, and degree of temptation in each scenario, as well as their tendency for self-control, interdependent view of self, and independent view of self. The results supported SAT in that the moral context positively and morality negatively predicted the likelihood of committing a crime. However, the results were inconsistent with SAT’s assertion that other variables influenced those with low morality more than those with high morality. Further, the tendency to have an interdependent view of self affected the likelihood of committing a crime in some scenarios. This result indicates that in some situations, some people are more influenced by expectations of their behavior from their surroundings, in addition to their morality. Future empirical studies of SAT are needed to examine the influence of self-control on criminal phenomena using the ability to exercise self-control in certain situations that conform to the concept of self-control advocated by SAT. Morality is also a crucial concept in the SAT. Therefore, future research should examine how the morality of trying to fulfill social role expectations and previously assessed morality influence the likelihood of committing a crime.
Monotonic and cyclic triaxial testing of untreated and polyurethane-treated soil and soil–rubber mixtures
Authors: Farooq Mohammad Adnan , Nimbalkar Sanjay 
Published: October 2023

AbstractThe present research focuses on developing alternate sustainable base materials for a high-speed slab track. In this study, a series of monotonic triaxial, cyclic triaxial and permeability tests were conducted on four types of materials, viz. mix-A (gravel soil), mix-B (soil mixed with rubber), mix-C (polyurethane foam adhesive (PFA)-treated soil), and mix-D (PFA-treated soil–rubber mixture). The influence of cyclic loading frequency, effective confining pressure, drainage condition and relative density on the deformation, excess pore water pressure, resilient modulus and damping ratio of these different mixes is evaluated. The monotonic triaxial test results indicate that the PFA treatment of mix-A and mix-B increased their shear strength and critical state strength. In contrast, incorporating rubber into mix-A and mix-C helped enhance their ductility. The cyclic triaxial test results show that the PFA treatment of mix-A and mix-B significantly reduced the magnitude of deformation and generation of excess pore water pressure, which caused these untreated mixes to fail prematurely under lower confinement to which a typical base layer is subjected. The influence of cyclic loading frequency and effective confining pressure on the material's response differed for untreated and treated soil. The permeability test results indicate good drainage for mix-D comparable to mix-A.
Frappe: fast fiducial detection on low cost hardware
Authors: Jones Simon , Hauert Sabine 
Published: October 2023

AbstractSquare fiducial markers are widely used in robotics to easily obtain pose and other information about the world from camera images. Processing the images to extract the markers is usually performed centrally with standard libraries but the code is typically aimed at PC-level hardware. Platforms with constrained processing power have difficulty handling multiple camera streams at real-time refresh rates. We introduce theFrappe(Fiducial Recognition Accelerated with Parallel Processing Elements) algorithm for detecting and decoding the popular ArUco tags. Designed to be implemented on the low cost hardware of the Raspberry Pi Zero, we show tag detection and decoding on images of 640 × 480 resolution exceeding 60 Hz, five times faster than the standard ArUco library, while maintaining similar detection performance and using much less energy. Using Frappe, we demonstrate improved real-world performance on a visual navigation task with our DOTS robot.
The Spectrum of Headache in Leptomeningeal Metastases: A Comprehensive Review with Clinical Management Guidelines
Authors: Wilcox Jessica A. , Estrera Rachel , Boire Adrienne 
Published: October 2023

Abstract
Purpose of Review
Headaches are a common, oftentimes debilitating symptom in patients with leptomeningeal metastases.

Recent Findings
The third edition of the International Classification of Headache Disorders provides a useful diagnostic framework for headaches secondary to leptomeningeal metastases based on the temporal relationship of headache with disease onset, change in headache severity in correlation with leptomeningeal disease burden, and accompanying neurologic signs such as cranial nerve palsies and encephalopathy. However, headaches in patients with leptomeningeal metastases can be further defined by a wide range of varying cancer- and treatment-related pathophysiologies, each requiring a tailored approach.

Summary
A thorough review of the literature and expert opinion on five observed headache sub-classifications in patients with leptomeningeal metastases is provided, with attention to necessary diagnostic testing, recommended first-line treatments, and prevention strategies.
Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy
Authors: Häussler Ute , Neres João , Vandenplas Catherine , Eykens Caroline , Kadiu Irena , Schramm Carolin , Fleurance Renaud , Stanley Phil , Godard Patrice , de Mot Laurane , van Eyll Jonathan , Knobeloch Klaus-Peter , Haas Carola A. , Dedeurwaerdere Stefanie 
Published: October 2023

AbstractStructural epilepsies display complex immune activation signatures. However, it is unclear which neuroinflammatory pathways drive pathobiology. Transcriptome studies of brain resections from mesial temporal lobe epilepsy (mTLE) patients revealed a dysregulation of transforming growth factor β, interferon α/β, and nuclear factor erythroid 2-related factor 2 pathways. Since these pathways are regulated by ubiquitin-specific proteases (USP), in particular USP15, we hypothesized that USP15 blockade may provide therapeutic relief in treatment-resistant epilepsies. For validation, transgenic mice which either constitutively or inducibly lack Usp15 gene expression underwent intrahippocampal kainate injections to induce mTLE. We show that the severity of status epilepticus is unaltered in mice constitutively lacking Usp15 compared to wild types. Cell death, reactive gliosis, and changes in the inflammatory transcriptome were pronounced at 4 days after kainate injection. However, these brain inflammation signatures did not differ between genotypes. Likewise, induced deletion of Usp15 in chronic epilepsy did not affect seizure generation, cell death, gliosis, or the transcriptome. Concordantly, siRNA-mediated knockdown of Usp15 in a microglial cell line did not impact inflammatory responses in the form of cytokine release. Our data show that a lack of USP15 is insufficient to modulate the expression of relevant neuroinflammatory pathways in an mTLE mouse model and do not support targeting USP15 as a therapeutic approach for pharmacoresistant epilepsy.
Sevoflurane Exposure Induces Neuronal Cell Ferroptosis Initiated by Increase of Intracellular Hydrogen Peroxide in the Developing Brain via ER Stress ATF3 Activation
Authors: Kang Liheng , Piao Meihua , Liu Nan , Gu Wanping , Feng Chunsheng 
Published: October 2023

AbstractNeuronal cell death is acknowledged as the primary pathological basis underlying developmental neurotoxicity in response to sevoflurane exposure, but the exact mechanism remains unclear. Ferroptosis is a form of programmed cell death characterized by iron-dependent lipid peroxidation that is driven by hydrogen peroxide (H2O2) and ferrous iron through the Fenton reaction and participates in the pathogenesis of multiple neurological diseases. As stress response factor, activating transcription factor 3 (ATF3) can be activated by the PERK/ATF4 pathway during endoplasmic reticulum (ER) stress, followed by increased intracellular H2O2, which is involved in regulation of apoptosis, autophagy, and ferroptosis. Here, we investigated whether ferroptosis and ATF3 activation were implicated in sevoflurane-induced neuronal cell death in the developing brain. The results showed that sevoflurane exposure induced neuronal death as a result of iron-dependent lipid peroxidation damage secondary to H2O2 accumulation and ferrous iron increase, which was consistent with the criteria for ferroptosis. Furthermore, we observed that increases in iron and H2O2 induced by sevoflurane exposure were associated with the upregulation and nuclear translocation of ATF3 in response to ER stress. Knockdown of ATF3 expression alleviated iron-dependent lipid peroxidation, which prevented sevoflurane-induced neuronal ferroptosis. Mechanistically, ATF3 promoted sevoflurane-induced H2O2 accumulation by activating NOX4 and suppressing catalase, GPX4, and SLC7A11 expression. Additionally, an increase in H2O2 was accompanied by the upregulation of TFR and TF and downregulation of FPN, which linked iron overload to ferroptosis induced by sevoflurane. Taken together, our results demonstrated that ER stress-mediated ATF3 activation contributed to sevoflurane-induced neuronal ferroptosis via H2O2 accumulation and the resultant iron overload.
Psychometric properties of the European Portuguese version of the modified perinatal PTSD questionnaire (PPQ-II)
Authors: Alves Stephanie , Claro Mariana , Beato Ana 
Published: October 2023

AbstractChildbirth-related posttraumatic stress symptoms (CB-PTSS) are prevalent and have pervasive consequences for the entire family. The development and validation of tools for screening CB-PTSS are deemed necessary to maximize prevention and intervention efforts. This study aims to examine the psychometric properties of the modified perinatal PTSD questionnaire (PPQ-II) in a sample of European Portuguese mothers. Four hundred and fifty-one women, from 1 to 18 months postpartum, participated in an online cross-sectional study that was conducted between February and March 2020. Participants completed the PPQ-II and the Depression Anxiety Stress Scales – 21 (DASS-21). Factor structure was estimated through an Exploratory (EFA; n = 229) and Confirmatory factor analysis (CFA; n = 222). Convergent and known-groups validity and internal consistency of the scale were also computed. The EFA suggested a 2-structure factor (Factor 1 “Arousal”, containing 7 items; and Factor 2 “Avoidance and Intrusion”, containing 4 items), accounting for 48.3% of the total variance of the scale. This factor structure was supported by the CFA, showing an adequate fit to the data. Convergent validity was shown by significant associations between the PPQ-II and DASS-21 subscales. Overall, the scale discriminated between at-risk and low-risk mothers. The McDonald’ omega coefficients attested the high reliability of the PPQ-2 (ranging from 0.78 to 0.89). The PPQ-II is a valid and reliable instrument to routinely screen for CB-PTSS in perinatal health services. It also adds to prior studies demonstrating its cross-cultural validity.