bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Characterization of Electrospinning Gelatin Nanofiber Membranes Containing Carvacrol Nanoparticles
Authors: Wang Yanan , Li Shiqing , Shi Wenhui , Li Shujing 
Published: January 2024

AbstractThe purpose of this study was to analyse the potential prospect of electrospinning gelatin nanofiber membranes containing carvacrol nanoparticles (G−Car−NPs−NF) as packaging material in food field. Sustained‐release antioxidant and antibacterial nanofiber membranes were prepared by incorporating the carvacrol nanoparticles (Car−NPs). Carvacrol (Car) was used to form nanoparticles with zein and sodium caseinate, and then electrospinning with gelatin‐based solution to form nanofiber membranes. The biological activities of composite nanofiber membranes were exhibited. The antioxidant capacity was characterized by the scavenging rate of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical. With the increase of the concentration of Car, the antioxidant capacity of G−Car−NPs−NF was gradually improved. In addition, G−Car−NPs−NF exhibited inhibitory effect on Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) and the inhibitory effect was positively correlated with the concentration. Moreover, the nanofiber membranes showed the slow‐release rate in vitro release and kept the appropriate concentration. These results were directly showed that G−Car−NPs−NF could be used as an effective packaging material for Car in food industry.
Pre‐equilibrium Approximation for Analysis of Chemical Kinetics in Chromatography: Application to Reversed‐Phase On‐column Kinetics of Decomposition of Murexide
Authors: Sangawitayakorn Chaksawat , Chantiwas Rattikan , Wilairat Prapin 
Published: January 2024

AbstractA kinetic process can sometimes be observed during a chromatographic separation. The chemical reaction is coupled with the rapid distribution of the reacting compounds between the mobile and stationary phases. The use of the pre‐equilibrium approximation enables the derivation of the rate law for the chemical reaction(s) taking place in the mobile and/or stationary phase. A simple procedure is proposed for writing down this rate equation. It can be applied to any on‐column reaction, whether reversible or irreversible. For first‐ or pseudo‐first‐order kinetics, integration of the rate equation gives an exponential function of concentration with respect to time. To demonstrate the application of the proposed method, the kinetics of the decomposition of murexide in a reversed‐phase C8 column was studied. Murexide decomposes through a fast reversible protonation process to give purpuric acid, which then decomposes irreversibly. The stopped‐flow HPLC technique was used to obtain the entire kinetic profile for the on‐column reaction. Additionally, the kinetics was measured off‐column using the same mobile phase. The values of the kinetic parameters obtained from the batch experiments enabled the determination of all kinetic parameters of the on‐column reaction using non‐linear least squares fitting of the derived rate equation.
Design, Synthesis, Biological Evaluation and Docking Study of A New Series of 9‐aminoacridine Derivatives as Anti‐inflammatory Agents
Authors: Zhao Zhanqiang , Song Jinqian , Shang Yehan , Shan Mengyi , Tang Leilei , Pang Tao , Ye Qing , Cheng Gang , Jiang Guojun 
Published: January 2024

Abstract9‐aminacrine (9‐AA), an external antibacterial agent, possesses important bioactivities for the treatment of cancer, viruses, and prion diseases. Recent research has revealed that 9‐AA has anti‐inflammatory effects through the up‐regulation of nuclear receptor subfamily 4 group A member 1 (NR4A1), but it is highly cytotoxic. To mitigate its toxicity, three series of novel 9‐AA derivatives were synthesized. The toxicity of all compounds was assessed, and some of the less toxic compounds were tested for in vitro anti‐inflammatory activities, leading to the establishment of structure‐activity relationships. In particular, 9‐amino‐8‐bromo‐3,4‐dihydroacridin‐1(2H)‐one exhibited relatively low toxicity and retained anti‐inflammatory activity, with a higher selectivity index compared to 9‐AA (3.44 versus 0.68). Expression experiments of inflammatory mediators revealed that this compound not only inhibited the gene expression of pro‐inflammatory factors, but also promoted the gene expression of anti‐inflammatory factors. Preliminary mechanistic studies suggested that it exerted anti‐inflammatory effects through the NR4A1/Interleukin‐10 (IL‐10)/suppressors of cytokine signalling 3 (SOCS3) signaling pathway. Furthermore, molecular docking studies indicating that it may exhibit anti‐inflammatory activity by inhibiting the protein targets phosphodiesterase‐4 (PDE‐4) and p38 mitogen‐activated protein kinases (MAPK). Based on our data, 9‐amino‐8‐bromo‐3,4‐dihydroacridin‐1(2H)‐one with its low toxicity and anti‐inflammatory properties, holds promise for further development as an anti‐inflammatory agent.
HA/PLA Composite Nanoparticles for Enhanced Oral Bioavailability of Capsaicin: Fabrication, Characterization and in vitro‐in vivo Evaluation
Authors: Zhu Yuan , Wang Haiqiao , Adu‐Frimpong Michael , Zou Zhihui , Jin Zhou , Zhang Peiyao , Xue Yuanyuan , Li Shuang , Xu Ying , Yu Jiangnan , Xu Ximing 
Published: January 2024

AbstractIn this paper, hydroxylapatite (HA) nanoparticles were constructed through the ultrasound‐assisted dispersion method. Using scanning electron microscopy (SEM), we studied the preparation methods of HA nanoparticles, and spherical HA nanoparticles with a size of about 50 nm were prepared. Besides, we constructed the HA/PLA composite nanoparticles with polylactic acid (PLA) as the material. The effects of different composite proportions on the HA/PLA composite nanoparticles were investigated before Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), Transmission electron microscope (TEM), and SEM, were applied to preliminary evaluate the effects of the above‐mentioned nanoparticles on capsaicin release. Through an in vitro study, we found that the release rate of the drug could be influenced by various release media and different compounding ratios (of HA and PLA). Furthermore, the pharmacokinetics study of capsaicin powder and capsaicin‐loaded HA/PLA composite nanoparticles demonstrated marked increased Cmax, prolongation of Tmax to 8 h, increased T1/2 and mean retention time (MRT) by 6.7 and 5.6 times respectively, coupled with 9240.2 % increase in relative bioavailability. Of note, HA/PLA composite nanoparticles showed good biocompatibility and exhibited good long‐term controlled release carriers, coupled with the ability to improve the solubility and bioavailability of a lipophilic drug.
Selective Functionalization of Indole: Synthesis of Bioinspired 2,2′‐thiobisindoles, 3‐substituted Oxindoles, and 1‐(chloromethyl) Indoline‐2‐dione in One‐pot manner
Authors: Sharma Supriya , Kumar Akhilesh , Erande Rohan D. 
Published: January 2024

AbstractIndolyl thioethers and indolin‐2‐one motifs are extremely common in pharmaceuticals and organic materials, therefore developing a method to create these scaffolds is considered to be a vital endeavour in the chemical sciences. Here we have reported a unified strategy developed by the fine‐tuning of catalyst‐solvent combination [SOCl2 /AlCl3 in CHCl3 and SOCl2/DMSO (1 : 1) in CHCl3 at 25 °C] towards selective functionalization of Indole to synthesize 2,2′‐thiobisindoles and 3‐chloro‐3‐alkyl substituted oxindoles selectively in one‐pot manner with good to satisfactory yield (52‐86 %; 26 Examples). In application, reactions of 3‐subsituted indole and isatin derivatives produced the 1‐(chloromethyl) indoline‐2,3‐diones by just changing the reaction condition (60 °C), which shows the synthetic utility of the developed method.
MnO2 Nanoparticle‐Loaded Self‐Doped (N/O) Porous Carbon Derived from Orychophragmus Violaceus for Application as a High‐Performance Supercapacitor
Authors: Ma Zihan , Li Shaoqi , Wang Lishuang , Chen Tingting , Wang Guangning 
Published: January 2024

AbstractWaste orychophragmus violaceus was used to prepare a novel 3D self‐doped (N/O) porous carbon (OPC). The aim was to expand the application and increase the value of waste orychophragmus violaceus. In order to improve its specific capacitance, composites OPC@MnO2x of OPC and MnO2 were prepared by simple hydrothermal method. In 6 M KOH, specific capacitance obtained by OPC at 1 A g−1 is 268 F g−1, surprisingly, specific capacitance of OPC@MnO232 can be up to 419 F g−1 at 1 A g−1 and its capacitance retention rate is as high as 83.62 % after 10000 cycles (20 A g−1). The energy density of OPC@MnO232//OPC asymmetric supercapacitor in 1 M Na2SO4 can even reach 14.22 Wh kg−1 at 400 W kg−1, besides, it showed good cycling stability after 10000 cycles (20 A g−1), with capacitance retention rate of up to 86.64 %. Finally, the device is tested in an application. Connecting two identical asymmetric supercapacitors in series enables red LED to emit greater than 90 s. Overall, this study confirms that the waste orychophragmus violaceus derived porous carbon can reduce the wastage of waste resource, additionally, the composite material prepared is an electrode material for high‐performance supercapacitors with broad prospects.
Dipyridine‐Thiophene‐Based Fluorescent Probe: Synthesis, Crystal Structure, and Selective Recognition of Cu2+ Ions
Authors: Zalmi Geeta. A. , Nadimetla Dinesh N. , Puyad Avinash L. , Narvekar Kedar U. , Hangarge Rahul V. , Bhosale Sheshanath V. 
Published: January 2024

AbstractAn efficient fluorescent sensory platform was designed and synthesized for recognition of copper ion (Cu2+) in presence over other competing ions. The probe DTBPA 1 was displayed fluorescence color change upon addition of Cu2+ ion which was also characterized by spectroscopic techniques especially the fluorescence and colorimetric methods. The probe showed turn‐off fluorescence response to the Cu2+ ion. The limit of detection for the probe was found to be 0.789 μM while binding stoichiometry for the probe to metal ion was found to be 2 : 1 tested by Jobs analysis. The binding constant for the probe was found to be 1.13×106 M−1. Further the probe was utilized for detection of trace amount of Cu2+ ion in real water sample with recoveries 98.24 %~104 %. The molecule was further utilized in test strip application. The calculated fluorescence quantum yield was found to be 3.2. The theoretically Density Functional Theory (DFT) calculations were performed for the probe using Gaussian 16 ab initio/DFT quantum chemical simulation and the DFT calculations were supporting the experimental findings.
In‐vitro evaluation of antimicrobial and anti‐inflammatory efficacy of the gelatin‐β‐cyclodextrin hydrogels as biodegradable carriers for rutin
Authors: Mourad Reda , El Mogy Soma A. , Darwesh Osama , Abdel‐Hakim Ahmed 
Published: January 2024

AbstractThis work targeted synthesizing covalently crosslinked gelatin‐βcyclodextrin (Gel‐βCD) hydrogels via the Schiff‐base reaction between the amino groups of Gel and aldehydic groups of βCD produced from periodate oxidation. Fourier transform infrared (FTIR) spectra, scanning electron microscope (SEM), water uptake (WU) and thermogravimetric analysis (TGA) showed the chemical structure, surface morphology and thermal properties of the crosslinked Gel‐βCD hydrogels. Rutin was loaded into the crosslinked hydrogels (Gel‐βCD‐R) and release profile was investigated. The antimicrobial and anti‐inflammatory activities of Gel‐βCD‐R hydrogels were assessed against Pseudomonas aeruginosa (gram negative), Staphylococcus aureus (gram positive) and Candida albicans (fungal strain) and human red blood cells membrane protection as well. Results of FTIR spectra, SEM, WU and TGA analysis showed the successful Schiff‐base Gel‐βCD hydrogels synthesis having porous structure, high swelling behavior and good thermal stability. Rutin release behavior was controlled in the developed hydrogels and after 24 h at pH 7.4 about 88 % and 95 % for Gel‐βCD2‐R and Gel‐βCD4‐R, respectively. The formulation Gel‐βCD2‐R hydrogel showed a significant antimicrobial activity; 98.35 %, 75.26 % and 94.67 % inhibition growth for P. aeruginosa, S. aureus and C. albicans respectively. Besides, the anti‐inflammatory result was 92 % that nominates the formulation Gel‐βCD2‐R hydrogel as a promising antimicrobial and anti‐inflammatory alternative in drug delivery.
Iron‐catalyzed, elemental selenium‐promoted cyclization of 2‐nitrobenzonitriles with arylacetic acids
Authors: Nguyen Thao T. , Chung Duy T. M. , Nguyen Khang X. , Nguyen Vy P. T. , Phan Nam T. S. , Nguyen Tung T. 
Published: January 2024

AbstractWe report herein a method for synthesis of 2‐arylquinazolin‐4(3H)‐ones via an iron‐catalyzed, elemental selenium‐promoted cascade annulation of 2‐nitrobenzonitriles with arylacetic acids. The reactions proceeded in the presence of iron(III) acetylacetonate catalyst, elemental selenium, and DABCO base. A wide range of functionalities, including unprotected alcohols, amines, methylsulfonyl, and halogen groups, were compatible with reaction conditions.
Synthesis and Anti‐inflammatory Effect of Simple 2,3‐Diarylindoles. On Route to New NSAID Scaffolds
Authors: Segura‐Quezada Luis A. , Alba‐Betancourt Clara , Chacón‐García Luis , Chávez‐Rivera Rubén , Navarro‐Santos Pedro , Ortiz‐Alvarado Rafael , Tapia‐Juárez Melissa , Negrete‐Díaz José V. , Martínez‐Morales Jesús F. , Deveze‐Álvarez Martha A. , Zapata‐Morales Juan R. , Solorio Alvarado César R. 
Published: January 2024

AbstractNitrogen‐containing drugs represent one of the worldwide most extensive sources of treatments for different diseases. Indomethacin as example, is one of the most important non‐steroidal anti‐inflammatories (NSAID) indol‐containing drug. Its relevance has been demonstrated the last 50 years with excellent pharmacological results. Its efficacy as an anti‐inflammatory treatment, inspired us the exploration of indol‐containing structurally less elaborated compounds which kept and/or improve the anti‐inflammatory activity compared with indomethacin. Herein is summarized and discussed our initial findings on the synthesis and anti‐inflammatory effect of different 2,3‐diarylindoles, designed for strategically favoring the plausible and selective interactions with COX‐2, on route to new simple NSAID scaffolds. The TPA model and formalin test were used in this study to generate inflammation in mice for conducting the assays with the synthesized 2,3‐diarylindoles. Docking analysis revealed stronger N−H indolic interactions with COX‐2 for 6‐methoxy‐2‐phenyl‐3‐(4‐chlorophenyl)‐1H‐indole, one of the most active of the synthesized compounds when compared with indomethacin. This, experimentally match with the anti‐inflammatory observed effect and putatively indicates the biochemical action mechanism.
Chiral Macroheterocycles as Inducers of Helical Liquid Crystals: Molecular Design, Specialty of Functioning
Authors: Burmistrov Vladimir A. , Aleksandriiskii Viktor V. , Novikov Igor , Koifman Oskar 
Published: January 2024

AbstractThe mini‐review is devoted to the influence of the structure and properties of chiral macroheterocyclic dopants on the induction of helical liquid‐crystalline phases. Using the example of solutions of synthetic porphyrins, camphor substituted hemiporphyrazines and tetrapyrazinoporphyrazines, as well as chemically modified natural macrocycles based on chlorin e6 derivatives and their metal complexes in nematic liquid crystals, the features of the mesomorphic, dielectric and rheological properties of induced spiral mesophases are discussed.
An Alternative Pathway for the Synthesis of Glycerol Phenylbutyrate
Authors: Suchetti Laura , Foray Gabriela , Tempesti Tomas C. , Ferrayoli Carlos 
Published: January 2024

AbstractHyperammonemia is a life‐threatening condition which can affect patients at any age. In pediatric patients, hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle deficiencies or organic acidemias. Glycerol phenylbutyrate (GPB) is an orphan drug used in the treatment of hyperammonemia. GPB is a triglyceride composed of three phenylbutyric acid (PBA) molecules esterified to a glycerol molecule, which is synthesized through the acyl chloride route using thionyl chloride as an acylating agent. In this work we have developed an alternative synthesis method to obtain GPB directly under ambient conditions and avoiding the use of chlorinated solvents. Moreover, the use of carbodiimides as coupling agents, instead of thionyl chloride, allowed the conversion to the GPB in higher yields and with higher purity, without the need for column purification. We present a methodology that allows the production of GPB in a simple, efficient and environmentally and human health friendly way.
Synthesis and Characterization of Pyrazole‐Triazolone Compound with Exceptional Heat Resistance
Authors: Zhang Han , Zhang Lu , Tariq Qamar‐un‐Nisa , Dong Wen‐Shuai , Zhang Chao , Zhang Jian‐Guo 
Published: January 2024

AbstractEfficiently constructing structures with high thermal stability is a key objective in the development of energetic compounds. However, the existing synthesis processes for heat‐resistant energetic materials are frequently hampered by their complexity and low yields. This study presents a significant breakthrough in addressing these challenges. It successfully synthesizes 4‐amino‐5‐(3‐amino‐1H‐pyrazole‐4‐yl)‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐one (APTO) using a streamlined two‐step process, achieving an impressive high yield of 87.5 %. The structure was determined through X‐ray single crystal diffraction analysis, revealing a nearly planar intramolecular structure. Hirshfeld surface analysis, weak interaction analysis, and aromaticity analysis were conducted, illustrating a substantial presence of hydrogen bonds and π ‐ π stacking interactions within and between molecules. These interactions contribute significantly to exceptional thermal stability of ATPO. Furthermore, the thermal stability of ATPO was confirmed through DSC analysis, exhibiting a decomposition temperature as high as 365.2°C. This temperature surpasses that of the heat‐resistant explosive HNS (325°C), further validating its excellent thermal stability. The construction of this conjugated structure offers valuable guidance for the future structural design of heat‐resistant energetic materials. It opens up possibilities for the development of novel compounds with improved thermal stability based on similar conjugated architectures.
A Metal‐Free KOtBu‐Mediated Protocol towards the Synthesis of Quinolines, Indenoquinolines and Acridines
Authors: Satya Kishore Pendyala , Gujjarappa Raghuram , Jagdishbhai Patel Mayur , Polina Saibabu , Kishore Putta V. P. Rama , Singh Virender , Malakar Chandi C. , Pralhad Pujar Prasad 
Published: January 2024

AbstractAn expeditious strategy has been developed for the synthesis of diverse quinolines, indenoquinolines and acridines using KOtBu‐mediated reaction conditions. The designed process utilizes 2‐aminoaryl carbaldehydes/2‐aminoaryl ketones and methyl/methylene group containing ketones as readily available feedstock. The chemical transformation was affected at room temperature within a short duration of time to obtain diverse N‐heterocycles yields up to 92 %. The established process also exhibits considerable functional group tolerance with an operational simplicity.
Porous Microneedles Through Direct Ink Drawing with Nanocomposite Inks for Transdermal Collection of Interstitial Fluid
Authors: Pang Yushuang , Li Yanyan , Chen Kerong , Wu Ming , Zhang Jiaxue , Sun Yuping , Xu Yurui , Wang Xiaoliang , Wang Qian , Ning Xinghai , Kong Desheng 
Published: January 2024

AbstractInterstitial fluid (ISF) is an attractive alternative to regular blood sampling for health checks and disease diagnosis. Porous microneedles (MNs) are well suited for collecting ISF in a minimally invasive manner. However, traditional methods of molding MNs from microfabricated templates involve prohibitive fabrication costs and fixed designs. To overcome these limitations, this study presents a facile and economical additive manufacturing approach to create porous MNs. Compared to traditional layerwise build sequences, direct ink drawing with nanocomposite inks can define sharp MNs with tailored shapes and achieve vastly improved fabrication efficiency. The key to this fabrication strategy is the yield‐stress fluid ink that is easily formulated by dispersing silica nanoparticles into the cellulose acetate polymer solution. As‐printed MNs are solidified into interconnected porous microstructure inside a coagulation bath of deionized water. The resulting MNs exhibit high mechanical strength and high porosity. This approach also allows porous MNs to be easily integrated on various substrates. In particular, MNs on filter paper substrates are highly flexible to rapidly collect ISF on non‐flat skin sites. The extracted ISF is used for quantitative analysis of biomarkers, including glucose, = calcium ions, and calcium ions. Overall, the developments allow facile fabrication of porous MNs for transdermal diagnosis and therapy.
Supramolecular Engineering of Ti3C2Tx MXene ‐Perylene Diimide Hybrid Electrodes for the Pseudocapacitive Electrochemical Storage of Calcium Ions
Authors: Goudar Soujanya H , Bhoi Shubham , Sahoo Saroj Kumar , Rao Kotagiri Venkata , Kurra Narendra 
Published: January 2024

AbstractThe rare combination of metallic conductivity and surface redox activity enables 2D MXenes as versatile charge storage hosts for the design of high‐rate electrochemical energy storage devices. However, high charge density metal ions including but not limited to Ca+2 and Mg+2 pose challenges such as sluggish solid‐state diffusion and also inhibiting the charge transfer across electrode‐electrolyte interfaces. In this work, free‐standing hybrid electrode architectures based on 2D titanium carbide‐cationic perylene diimide (Ti3C2Tx@cPDI) via supramolecular self‐assembly are developed. Secondary bonding interactions such as dipole‐dipole and hydrogen bonding between Ti3C2Tx and cPDI are investigated by zeta potential and Fourier‐transformed infrared (FTIR) spectroscopy . Ti3C2Tx@cPDI free‐standing electrodes show typical volumetric capacitance up to 260 F cm−3 in Mg2+ and Ca2+ aqueous electrolytes at charging times scales from 3 minutes to a few seconds. Three‐dimensional (3D) Bode maps are constructed to understand the charge storage dynamics of Ti3C2Tx@cPDI hybrid electrode in an aqueous Ca‐ion electrolyte. ,Pseudocapacitance is solely contributed by the nanoscale distribution of redox‐active cPDI supramolecular polymers across 2D Ti3C2Tx. This study opens avenues for the design of a wide variety of MXene@redox active organic charge hosts for high‐rate pseudocapacitive energy storage devices.