bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRTUIN 1 ISOFORMS DIFFERENTIALLY IMPACT MITOCHONDRIAL GENE EXPRESSION AND FUNCTION IN MUSCLE CELLS
Authors: Zhang Xiaomin , Patyal Pankaj , Verma Ambika , Sharma Shakshi , Azhar Gohar , Ameer Fathima , Che Yingni , Wei Jeanne 
Published: December 2023

Abstract

Background
Alternative splicing (AS) is a mechanism that generates multiple mRNA transcripts and protein isoforms from a single gene, thereby increasing transcriptomic and proteomic diversity. The spliced isoforms commonly lack one or more exons, which may have similar or even opposite functions. Alternatively spliced isoforms tend to increase during aging. The sirtuin-1 gene contains multiple exons and undergoes alternative splicing, which generates multiple isoforms. In this study, we assessed the impact of three sirtuin-1 isoforms on mitochondrial gene expression and function in muscle cells.

Methods
Three sirtuin-1 isoforms (V1, V2, V3) were subcloned into expression vectors. Muscle cell lines (H9C2 and C2C12) were transfected with sirtuin-1 isoforms, respectively. Microscopic images were obtained using a Nikon microscope. Gene expression was determined by quantitative RT-PCR and Western blotting. The mitochondrial function was determined with a Seahorse XFe96 Analyzer. Results and conclusions The sirtuin-1 V1 isoform significantly increased the oxygen consumption rate (OCR) and decreased glycolysis (ECAR) in muscle cells, while V2 and V3 isoforms had slight or no significant effect on OCR and ECAR. V1 isoform was localized in the nucleus, whereas V2 and V3 were localized in the cytoplasm. Sirtuin-1 isoforms differentially impacted mitochondrial complex genes, including NDUFS1, NDUFV1, NDUFV2, NDUFA5. Our data indicate that the domain loss changed sirtuin-1 isoform subcellular localization, differentially impacted mitochondrial gene expression, and affected mitochondrial function. The age-related change in the expression of sirtuin-1 isoforms could affect cardiac and skeletal muscle function in aging and senescence. Further exploration of the sirtuin-1 isoforms’ functions is warranted.
DIGNITY THERAPY FOR OLDER ADULTS WITH CANCER: COMMUNION FACILITATES DIGNITY
Authors: Bluck Susan , Koch Mary Kate , Maggiore Sophia , Wilkie Diana , Chocninov Harvey , Bylund Carma 
Published: December 2023

Abstract
Nearly 600,000 older Americans die a cancer-related death annually. Maintaining dignity is central to their quality of life. Dignity Therapy (DT; Chochinov, 2005) was designed to preserve dignity despite health declines. Patients report benefits of DT but mechanisms have not been empirically investigated. Grounded in gerontological life review research, DT involves therapists guiding patients to tell their unique life story and leave a legacy. This study investigates level of communion in the life story told in DT as a mechanism for DT efficacy. Communion reflects personal strivings for warm and close relationships (McAdams, 1986). Participants were 204 older cancer patients receiving outpatient palliative care (Mage= 66 years, SD = 7.43, 65% female) who participated in DT. Session narratives were audio-recorded and reliably (κ=.71–1) content-analyzed for communion themes (McAdams, 2001). Participants completed pre-post measures, including the Dignity Impact Scale. Mediation analyses showed significance for the direct effect of Dignity Impact from pre- to post-test, B = .50(.06), p &lt; .001 as well as for paths from pre-test Dignity to Communion, B = .20(.08), p &lt;.01 and from Communion to post-test Dignity, B = .20(.06), p = .001. Sobel test for the mediation effect of Communion between pre- to post-test Dignity was z = 2.06(.02), p = .039; point effect = .04. Participating in DT is shown to increase older cancer patients’ feelings of dignity. That is partially explained by the extent to which these older adults tell a life story rich in communion, reflecting on loving, caring relationships, during DT.
ECONOMIC BOOM AND FINANCIAL RECESSION—WHAT ARE THE EFFECTS ON RELOCATION PATTERNS FOR OLDER ADULTS?
Authors: Dahlgren David , Hansson Asa , Iwarsson Susanne , Schmidt Steven , Kylén Maya 
Published: December 2023

Abstract
While previous research shows that older adults choose to relocate to a different home for numerous reasons (e.g., changes in the household composition, health decline), little is known about the influence of economic factors. The economic situation on aggregated level can influence the individual in more ways than by consumer demand and income, for example, financial crisis, fluctuating housing prices, and more general uncertainties about the future. Representing a novel approach, the aim of this study was to investigate the impact of macroeconomic events on relocation rates among older adults in Sweden. We used high quality panel data from Swedish registers, based on a random sample made 1994 with 300,000 individuals. Data was analyzed from 1970-2016 using a repeated cross-sectional design. Preliminary results show that the number of relocations was volatile the first year of a financial crisis. Depending on the characteristics of the crisis, the number of relocations decreased or increased; crises that are less connected to the property market had a reduction in number of relocations. This effect was observed for 1-2 years and stabilized to “normal levels” in the subsequent years. Especially high volatility was observed for the older age groups (75-84 and 85-90), which could be because they have a shorter time horizon for investment planning and great need to transfer housing wealth to liquidity. Knowledge in this field enables policymakers to plan housing investment, and negative shocks to the economy may lead to short term impacts on the housing market for older adults.
FORGING COMMUNITY–ACADEMIC PARTNERSHIPS FOR HEALTHY AGING: A COMMUNITY-LED TOOLKIT TO COMBAT AGEISM
Authors: Urbanski Dana , Johnson Elma , Almiron Maby , Chapman Steve , Keinan Amina , Thomas Phyllis , Yang Mayla , Frazier Robbin 
Published: December 2023

Abstract
There is growing recognition that community-engaged research approaches are essential for bridging the evidence-to-practice gap, especially for minoritized communities underrepresented among academic researchers. Such approaches often adopt a consultative model in which community members provide insights, perspectives, and feedback to support academic-driven projects. This strategy can be mutually beneficial when paired with cultural sensitivity and humility; however, there is a pressing need to form community-academic partnerships that flip this consultative relationship—placing university researchers as advisers on community-led projects that reflect local needs, priorities, and values. Here, we highlight the work of one such community-academic partnership led by the Center for Healthy Aging and Innovation’s (CHAI’s) Community Advisory Board with support from University of Minnesota faculty, staff, and graduate students. First, we describe the vision and formation of our Community Advisory Board (CAB), along with recruitment of its diverse membership representing eight cultural communities of the Twin Cities. We then outline the collaborative needs assessment process by which the CAB identified and prioritized action areas to advance healthy aging and health equity. Finally, we present preliminary results and early lessons learned from the CAB’s first project initiative—creation of a community-led, culturally responsive toolkit to address and reframe community-based sources of age-related stigma and discrimination. Findings from this project: 1) offer a plausible model and process for community-academic engagement which may be adapted and refined to fit local contexts; 2) underscore the value of community-led academic partnerships for addressing age-related stigma and other social factors associated with poor aging outcomes.
HOW NOT TO DATA ARCHIVE IN 10 WAYS
Authors: Millenbah Ashley , Albers Elizabeth , Louwagie Katie 
Published: December 2023

Abstract
Data sharing offers opportunities to replicate published findings, improves transparency in science, and increases the impact of the research by allowing other researchers to conduct new analyses. Effective January 25, 2023, the National Institute on Aging has new mandates for data sharing. However, many researchers are not experienced in data sharing and curation. Researchers will need to become more familiar with data sharing, specifically archiving data in data repositories. With these new requirements, many teams are attempting data sharing or archiving for the first time. We present 10 lessons learned the hard way, from real experience, prohibiting successful data archiving. Many of the challenges encountered could be avoided by effective planning, such as securing funding for curation and/or de-identification, adding data archiving details into the grant, and finding multiple repositories to potentially use. Other problems can be avoided by writing a consent form that allows for data archiving, such as by not limiting access to data, or limiting the type or format of data to be shared. Consulting with a legal team with experience in data archiving, such as at a data repository, is also recommended. By avoiding these pitfalls, researchers can successfully archive their data, ensuring their data are maintained and usable for other researchers in the future.
UTILIZING CARE PREFERENCE ASSESSMENT TO UNDERSTAND THE NEEDS OF OLDER ADULTS AT ADULT DAY SERVICES (ADS) IN TAIWAN
Authors: Liou Chih-ling 
Published: December 2023

Abstract
Understanding individuals’ preferences and honoring them throughout the care delivery process is essential for care services. When preferences are understood and honored, care recipients perceive a greater sense of autonomy, which improves their quality of life and emotional well-being. Adult Day Services (ADS), a fast-growing community service offers daytime programs for those with physical and/or cognitive impairments. In order to better understand ADS attendees’ care preferences and to help ADS staff to deliver person-centered care in Taiwan, this study adapted the Preferences for Everyday Living Inventory for ADS in Chinese (PELI-ADS-C) to assess preferences for activities and lifestyle experiences. Forty-three interviews were conducted with older adults recruited from three different ADS centers in Taiwan. The majority of participants were females (85%) with ages ranging from 67 to 93 years old. Among the 43 preference items, “do things with groups of people” and “participate in religious services or practices” were rated as most important followed by “reminisce about the past” and “exercise.” “Volunteer your time” and “gender of the staff taking care of you” were rated as least important. Participants shared that “It is not good for us to be alone.” “It is more fun for me to be with a group of people.” “I had no time to be a volunteer when I was younger. Now, I have to attend the center every day with no time to be a volunteer.” Results can be shared with ADS staff to develop care and activities that corresponded with attendees’ preferences.
ALCOHOL CONSUMPTION AMONG ADULTS IN WISCONSIN
Authors: Carney Amy Knepple , Manders Imagine , Hammond Allison , Wessel Leslie 
Published: December 2023

Abstract
Alcohol usage as we age can lead to worsening health conditions and higher rates of accidents. There have been mixed results on alcohol use in adulthood, and many of these studies use only one metric of alcohol consumption. With higher-than-average (55.1%) drinking rates in the United States, Wisconsin currently ranks third highest for adult alcohol consumption (64.4%), it is essential to understand age trends for nondrinking, binge drinking, and heavy drinking. Using 2021 data from the CDC, we examined a series of logistic regressions to determine age differences in alcohol consumption. First, whether a person had at least one drink in the past 30 days, odds ratios show that relative to older adults (65+), 45-to-64-year-olds are 1.35 times more likely, 25-to-44-year-olds are 1.72 times more likely, and 18–to-24-year-olds are 1.09 times more likely to have reported having at least one drink in the last 30 days. Second, binge drinking, odds ratios show that relative to older adults (65+), 45-to-64-year-olds are 2.95 more likely, 25-to-44-year-olds are 5.41 times more likely, and 18-to-24-year-olds are 3.86 times more likely to binge drink. Last, heavy drinking, odds ratios show that relative to older adults (65+), 45-to-64-year-olds are 1.84 more likely, 25-to-44-year-olds are 1.94 times more likely, and 18-to-24-year-olds are 1.71 times more likely to drink heavily. Implications of these results are examined more fully but include the adverse effects on health for young-to-middle-aged adults, the potential to die younger for heavy drinkers, and the positive effects of lower drinking rates in later adulthood.
ASSOCIATIONS BETWEEN DAILY STRESSORS AND ALCOHOL USE IN THE MIDUS STUDY
Authors: Miller Sara , Almeida David 
Published: December 2023

Abstract
Daily stressors are minor but frequent challenges of everyday life (e.g., arguments). Although daily stressors are typically less severe than stressful life events, daily stressors can have more immediate effects on wellbeing. Despite this relevance, there is limited research evaluating the influence of daily stressors on alcohol use in older populations. This study examined daily associations between stressor characteristics (exposure, type, and severity) and alcohol use and evaluated differences in associations for younger/middle-aged (&lt; 65 years) vs older adults (65+ years). Participants (n=1,603; Mage=52.82) were non-abstaining adults from the Midlife in the United States (MIDUS) study and the MIDUS Refresher who participated in 8-day diary projects. Survey items included stressor exposure (1=yes), stressor types (interpersonal, work, home, network), stressor severity (0=not at all; 1=not very; 2=somewhat; 3=very), and number of drinks. Covariates included the day of the week, sociodemographic characteristics, personality traits, psychological factors, and health behaviors. Multilevel linear regression analysis revealed that neither daily stressor exposure nor stressor severity was associated with reported alcohol use (p&gt;0.05), but there were differences in alcohol use by stressor type. Specifically, days with interpersonal stressors were associated with reporting more drinks (p=.049), while days with work stressors were associated with reporting fewer drinks (p=.001). Further, age significantly moderated the relationship between any stressor exposure and reported alcohol use (p=.035), such that stronger relationships were observed for older adults than younger/middle-aged adults. Study findings highlight the importance of considering stressor characteristics when evaluating the covariation of daily stressors and alcohol use.
RISKY BEHAVIORS WITH NONALCOHOLIC FATTY LIVER (NAFLD) AND NONALCOHOLIC STEATOHEPATITIS (NASH) AMONG OLDER ADULTS
Authors: Tseng Tung-Sung , Lin Wei-Ting , Ting Peng-sheng , Huang Chiung-Kuei , Chen Po-Hung , Lin Hui-Yi 
Published: December 2023

Abstract

Background
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging public health concerns among older adults, particularly those with risk behaviors.

Objectives
We evaluate the association between risk behavior and the prevalence of NAFLD and NASH in older adults.

Methods
A total of 1444 US individuals aged 60 years and older were included from the 2017- 2020 NHANES survey. Dietary, Sugar-sweetened beverages, smoking, physical activities, stiffness, controlled attenuation parameters, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured. We performed multivariable logistic regression models with interaction terms and stratified analysis to assess the interplay effect between soda intake and body mass index (BMI) on liver stiffness measurements. All statistical analyses were under survey modules with an appropriate sampling weight.

Results
The prevalence of NAFLD/NASH varied significantly by age, gender, race, alcohol use, BMI, total energy consumption, ALT, and (all p≤0.001). The results showed that several risk behaviors, including smoking, physical inactivity, and sweetened beverage consumption, were not significantly associated with developing and worsening NAFLD and NASH among elderly individuals. However, higher total energy consumption, obesity, and alcohol use were risk factors for NAFLD/NASH.

Conclusion
Our study findings highlight the importance of promoting some healthy lifestyle behaviors among elderly individuals to prevent the development and progression of NAFLD and NASH. Further research is needed to investigate optimal strategies for promoting healthy beh
EFFECTS OF ACTIVITIES ON THE PSYCHOLOGICAL WELL-BEING OF CAREGIVERS OF OLDER ADULTS
Authors: Won Sarah , Regier Natalie 
Published: December 2023

Abstract
It is well-known that the caregiving role is perceived as stressful and is often associated in the literature with decreased well-being. Given that approximately 41.8 million Americans provide unpaid care to an older adult, it is critical to identify strategies or interventions to maximize their well-being. Activity engagement is one such promising intervention. Consequently, the goal of this study was to investigate which activities of caregivers of older adults significantly improve their well-being. To that end, a three-stage literature review (title/abstract review, full-text review, reference list review) was conducted, resulting in a total of 2,959 articles identified in PsycINFO. Inclusion/exclusion criteria narrowed this down to 24 relevant full-text research articles. Results showed a total of eight cohesive categories of activities for caregivers: Physical (n=5), Social (n=5), Arts/entertainment in the home (n=2), Arts/entertainment outside of the home (n=2), Religious/Spiritual (n=4), Psychotherapy (n=5), Psychoeducation (n=3), and Multimodal (n=4). Indicators of caregiver well-being in the outcome variables of studies included depressive symptoms, overall mental health, stress-induced cellular aging, life satisfaction, distress, quality of life, caregiver burden, satisfaction with the caregiving role, salivary cortisol, caregiver mastery, and stress. Activity categories that had the greatest frequency of positively impacting caregiver well-being were physical activities, social activities, religious/spiritual activities, and psychoeducational activities. All other activity categories except for arts/entertainment activities outside of the home were effective in some studies in improving caregiver well-being. Findings suggest that caregivers of older adults should seek opportunities for engagement in meaningful activity, particularly physical, social, religious/spiritual, and psychoeducational activities.
PERCEPTIONS ON A DIGITAL HEALTH PHYSICAL ACTIVITY PROGRAM IN OLDER FAMILY CARE PARTNERS OF PERSONS WITH HEART FAILURE
Authors: Baik Dawon 
Published: December 2023

Abstract
Many family care partners (FCPs) neglect managing their own health and wellness when providing care to others. Older FCPs are more vulnerable in managing their health because of physical and psychological distress, age-related health needs, and less social support. We developed a digital health physical activity (PA) program, TPA4You, to begin to address these issues. We elicited perceptions of the integrated components of TPA4You (i.e., Zoom PA with a health coach, Fitbit, motivational text messaging) among older FCPs of persons with heart failure (HF-FCPs) using scenario-based design methods. Participants were recruited at the University of Colorado Hospital between September and December 2022. Fifteen qualitative interviews were conducted. Mean age was 65.9±4.4 years, 73% female, 93% White, and 13/15 were spouses. The perceived value of TPA4You was reported as (1) convenience because travel not required, (2) increased motivation from being held accountable by the separate technology components, and (3) consideration of improving FCPs’ health and wellness. Challenges described were (1) scheduling, finding time dedicated to exercising with the health coach by Zoom and (2) feeling overwhelmed, integrating the technology components in the FCP’s life. The keys to motivating PA and exercise through TPA4You were (1) usefulness of content in text messages and a good relationship with the health coach, (2) encouragement provided by TPA4You engagement, and (3) desire to improve their health and quality of life. Future studies should conduct field-testing of TPA4You in older HF-FCPs by providing one-on-one, hands-on sessions using the integrated technology components to optimize usability and acceptability.
BARRIERS TO DISEASE SELF-CARE AMONG OLDER NON-HISPANIC BLACK AND HISPANIC MEN WITH CHRONIC CONDITIONS
Authors: Smith Matthew , Bergeron Caroline , Sherman Ledric , Oloruntoba Oluyomi , Merianos Ashley 
Published: December 2023

Abstract
Disease self-care is multi-faceted and influenced by physical, mental, social, and environmental factors. Because males traditionally underutilize preventive healthcare services, self-care is increasingly important to manage disease symptomatology and slow disease progression. This study examines factors associated with barriers to disease self-care among Hispanic and non-Hispanic Black men ages ≥65 years with ≥1 chronic condition. Data were analyzed from a national sample of 470 Hispanic (43.2%) and non-Hispanic Black (56.8%) men and collected with an internet-delivered questionnaire. The 5-item Barriers to Self-Care Scale served as the dependent variable (range=5-20). A least squares regression model was fitted to identify factors associated with barriers to disease self-care. The model adjusted for sociodemographics, disease characteristics, health status, and social engagement and support. On average, participants were age 70.1 (±4.5) years and reported 3.9 (±2.6) chronic conditions. Men with higher body mass index (β=0.13, P=0.001), more depressive symptomatology (β=0.09, P=0.046), and lower self-rated quality of life (β=-0.23, P&lt; 0.001) reported higher barriers to disease self-care. Further, men with poorer access to healthcare (β=-0.17, P&lt; 0.001) and higher healthcare frustrations (β=0.17, P&lt; 0.001) reported higher barriers to disease self-care. Barriers to self-care were positively associated with being more socially disconnected (β=0.09, P=0.049) and higher reliance on others to manage health problems (β=0.14, P&lt; 0.001). Findings reinforce the importance of mental health, healthcare access, and social support for disease self-management among Hispanic and non-Hispanic Black men. Efforts are needed in clinical and community-based settings to reduce self-care barriers through culturally appropriate self-management education, interventions, and services.