bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT OF RELIGIOUS MODERATION IN NORTH SUMATERA COMMUNITIES BY STRENGTHENING CROSSCULTURAL COMMUNICATION BASED ON LOCAL WISDOM VALUES
Authors: Mailin Mailin , Sazali Hasan , Dharma Suhesti Wira 
Published: November 2023

<p class="07AbstrakInggris">The application of religious moderation using a cultural approach and local wisdom is very necessary because of the multicultural conditions of the North Sumatera region then there was the ambush of modernization and the presence of global culture hegemony. While the cultural approach and local wisdom can be done by using cross-cultural communication to avoid conflicts between different cultural groups And also maintain harmony between cultural groups. This study aims to determine the understanding of the people of North Sumatra on religious moderation and to find out the local wisdom that exists in the people of North Sumatra in line or not with the concept of religious moderation. This research uses qualitative methods with a descriptive approach, data wascollected using unstructured interviews and documentation. The determination of informants is carried out using purposive sampling techniques. The data analysis process is carried out by reducing data, presenting data and verifying. The results of the research showed that the people of North Sumatera Utara understand religious moderation through tolerance and harmony among religious people and among the values of local wisdom that exist in the people of North Sumatera is in line with the concept of religious moderation pioneered by the Ministry of Religious Affairs of the Republic of Indonesia, this has beeb proven by the culture that exists in North Sumatera since a long time ago has embraced an attitude of tolerance and harmony in carrying out daily life so as to create a harmonious relationship among the existing diversity.</p>
Descriptive study of Extragastrointestinal Manifestations of Ulcerative Colitis and their relation to disease activity in 100 Iraqi patients
Authors: Al-Khazraji Khalid A. 
Published: November 2023

Background: Ulcerative colitis is a chronic inflammatory bowel disease (IBD); its extragastrointestinal manifestations vary from one country to another. This study identifies the prevalence of the extragastrointestinal manifestations in a sample of Iraqi patients with ulcerative colitis and their relation to disease activity.Patients and Methods: A descriptive study was conducted on 100 patients with established diagnosis of ulcerative colitis, who attended Baghdad Teaching hospital and Gastroenterology center in Baghdad during the period from May 2009 to January 2010. A direct interview and thorough clinical examination were done to determine the history of the disease, its severity and the presence or absence of the extraintestinal manifestations.Result: The Extragastrointestinal manifestations were observed in 17 patients (17%). The most common EGlMs were the peripheral arthritis and mouth ulcer. The EGlMs were more common in patients with severe disease.Conclusion: The EGlMs of ulcerative are less common in Iraqi patients than in patients from western countries, but their relation with disease activity was relatively similar.
Management of Esophageal Foreign Bodies, retrospective study.
Authors: Nemat Mohammed H. , Hussein Abdulameer M. , Juma Uday H. 
Published: November 2023

Background: Foreign body impaction in the esophagus is a common problem. Our Objective is to draw conclusions from a retrospective over viewing a number of cases to assess current methods of management and to come out with recommendation from collected experience.Patient and method: A retrospective study of (62) patients admitted to the Department of Thoracic and Cardiovascular Surgery at Medical City Teaching Hospital from January 2002 to December 2004 with history of foreign body swallowing and impaction. Six patients excluded from the (62) patients after having negative esophgoscpic findings. On presentation, history about type and time of ingestion, associated signs and symptoms were recorded, x- ray was taken. Rigid esophagoscopy or direct laryngoscopy and Magill forceps has been used. After the procedure completion, type and site of the foreign body and state of esophageal mucosa at the site of impaction were recorded. Chest Xray done postoperatively in certain patients when we had peroperative findings of bleeding, suspicion of perforation. All patients except 2 were discharged within 24 hours after the procedure.Results: The results showed that the commonest age group was among children between 1-10 years (27) patients, and 77% of the patients presented with dysphagia as the most common presenting symptom, site of impaction mostly in upper third of esophagus 68%, and 68% of the FB were radiopaque. Types of the FB were versatile but 50% of them were metalic objects.Conclusion: Esophageal FB is a common problem especially among children; it requires urgent intervention because of its deleterious complications if left untreated.Suspecion is enough indication especially in children. Management requires good experience in using the appropriate tools like Magill forceps, which is safe and quick in good hands.
Relationship Between Sphingomyelin and Risk of Alzheimer’s Disease: A Bidirectional Mendelian Randomization Study
Authors: Zhu Haohao , Lu Rongrong , Zhou Qin , Du Zhiqiang , Jiang Ying 
Published: November 2023

Background: Alzheimer’s disease (AD) is a complex neurodegenerative disorder whose etiology involves multiple genetic and environmental factors. Sphingomyelin (SM) is a type of sphingolipid found in cell membranes, and recent evidence suggests a potential link between SM and AD. However, the nature of this relationship remains unclear. Objective: To elucidate the potential causal relationship between SM levels and the risk of developing AD using a two-sample Mendelian randomization approach. Methods: The study utilized data extracted from the genome wide association study database. The primary analysis method was the inverse variance weighted (IVW) method, which was supplemented by weighted median, weighted mode, and MR Egger methods. The study specifically investigated the bidirectional causal relationship between SM and AD, evaluating odds ratios (OR) with a 95% confidence interval (95% CI). Results: Elevated levels of SM were found to be a risk factor for AD, as shown by IVW(MRE) [OR: 1.001, 95% CI: 1.000 to 1.002; p = 0.020 < 0.05], IVW(FE) [OR: 1.001, 95% CI: 1.001 to 1.002; p = 3.36e-07 < 0.05], and MR Egger. Conversely, AD was demonstrated to lead to an increase in SM levels [IVW(MRE): OR: 5.64e+08, 95% CI: 1.69e+05 to 1.89e+12; p = 1.14e-06 < 0.05], with consistent findings across the IVW(FE), MR Egger, weighted median, and weighted mode methods. Conclusions: The study establishes a bidirectional positive correlation between SM and AD. Increased SM levels are associated with a higher risk of developing AD, and the presence of AD can further elevate SM levels, potentially exacerbating the disease’s progression.
Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma
Authors: Hammad Gehan , Mamdouh Samah , Seoudi Dina Mohamed , Seleem Mohamed Ismail , Safwat Gehan , Mohamed Rania Hassan 
Published: November 2023

BACKGROUND: P-Element-induced wimpy testis (PIWI) proteins, when in combination with PIWI-interacting RNA (piRNA), are engaged in the epigenetic regulation of gene expression in germline cells. Different types of tumour cells have been found to exhibit abnormal expression of piRNA, PIWIL-mRNAs, and proteins. We aimed to determine the mRNA expression profiles of PIWIL1, PIWIL2, PIWIL3, & PIWIL4, in hepatocellular carcinoma patients, and to associate their expression patterns with clinicopathological features. METHODS: The expression patterns of PIWIL1, PIWIL2, PIWIL3, PIWIL4 mRNA, was assessed via real-time quantitative polymerase chain reaction (RT-QPCR), on tissue and serum samples from HCC patients, their impact for diagnosis was evaluated by ROC curves, prognostic utility was determined, and In Silico analysis was conducted for predicted variant detection, association with HCC microRNAs and Network Analysis. RESULTS: Expression levels were significantly higher in both HCC tissue and serum samples than in their respective controls ([Formula: see text] 0.001). Additionally, the diagnostic performance was assessed, Risk determination was found to be statistically significant. CONCLUSION: PIWIL mRNAs are overexpressed in HCC tissue and serum samples, the expression patterns could be valuable molecular markers for HCC, due to their association with age, tumour grade and pattern. To the best of our knowledge, our study is the first to report the expression levels of all PIWIL mRNA and to suggest their remarkable values as diagnostic and prognostic biomarkers, in addition to their correlation to HCC development. Additionally, a therapeutic opportunity might be also suggested through in silico miRNA prediction for HCC and PIWIL genes through DDX4 and miR-124-3p.
Long-Term Outcome of Infantile Onset Pompe Disease Patients Treated with Enzyme Replacement Therapy - Data from a German-Austrian Cohort
Authors: Pfrimmer Charlotte , Smitka Martin , Muschol Nicole , Husain Ralf A. , Huemer Martina , Hennermann Julia B. , Schuler Rahel , Hahn Andreas 
Published: November 2023

Background: Enzyme replacement therapy (ERT) with recombinant human alglucosidase alfa (rhGAA) was approved in Europe in 2006. Nevertheless, data on the long-term outcome of infantile onset Pompe disease (IOPD) patients at school age is still limited. Objective: We analyzed in detail cardiac, respiratory, motor, and cognitive function of 15 German-speaking patients aged 7 and older who started ERT at a median age of 5 months. Results: Starting dose was 20 mg/kg biweekly in 12 patients, 20 mg/kg weekly in 2, and 40 mg/kg weekly in one patient. CRIM-status was positive in 13 patients (86.7%) and negative or unknown in one patient each (6.7%). Three patients (20%) received immunomodulation. Median age at last assessment was 9.1 (7.0–19.5) years. At last follow-up 1 patient (6.7%) had mild cardiac hypertrophy, 6 (42.9%) had cardiac arrhythmias, and 7 (46.7%) required assisted ventilation. Seven patients (46.7%) achieved the ability to walk independently and 5 (33.3%) were still ambulatory at last follow-up. Six patients (40%) were able to sit without support, while the remaining 4 (26.7%) were tetraplegic. Eleven patients underwent cognitive testing (Culture Fair Intelligence Test), while 4 were unable to meet the requirements for cognitive testing. Intelligence quotients (IQs) ranged from normal (IQ 117, 102, 96, 94) in 4 patients (36.4%) to mild developmental delay (IQ 81) in one patient (9.1%) to intellectual disability (IQ 69, 63, 61, 3x <55) in 6 patients (54.5%). White matter abnormalities were present in 10 out of 12 cerebral MRIs from 7 patients. Conclusion: Substantial motor, cardiac, respiratory, and cognitive deficits are frequent in IOPD long-term survivors who started ERT before 2016. The findings of this study can be valuable as comparative data when evaluating the impact of newer treatment strategies including higher enzyme dosage, immunomodulation, modified enzymes, or early start of treatment following newborn screening.
Nasal continuous positive airway pressure practices in preterm infants: A survey of neonatal providers
Authors: Mamidi R.R. , MacDonald K.D. , Brumbach B.H. , Go M.D.A. , McEvoy C.T. 
Published: November 2023

BACKGROUND: The standard of care for respiratory support of preterm infants is nasal continuous positive airway pressure (CPAP), yet practices are not standardized. Our aim was to survey CPAP practices in infants < 32 weeks gestation among the American Academy of Pediatrics Neonatal-Perinatal section. METHODS: A US, web-based survey inquired about the initiation, management, and discontinuation of CPAP, and chinstrap use and oral feedings on CPAP. RESULTS: 857 providers consented. Regarding criteria to discontinue/wean CPAP: 69% use specific respiratory stability criteria; 22% a specific post-menstrual age; 8% responded other. 64% did not have guidelines for CPAP discontinuation; 54% did not have guidelines for CPAP initiation. 66% believe chinstraps improve CPAP efficacy; however, 11% routinely apply a chinstrap. 22% allow oral feeds on CPAP in certain circumstances. CONCLUSION: There are meaningful variabilities in CPAP practices among neonatal providers across the US. Given the potential long-term implications this can have on the growth and development of the preterm lung, further evidence-based research is needed in relation to respiratory outcomes to optimize and standardize CPAP strategies.
The effects of physical treatment on physicochemical and biological properties of water and aqueous solutions
Authors: Don E. S. , Stepanov G. O. , Tarasov S. A. 
Published: November 2023

Objectives. Changes to the properties of water caused by factors such as pressure or temperature, can only be explained by its structural changes. Scientists study changes to the properties of water due to various physical stimuli only without the addition of any substances. Examples of stimuli are acoustic exposure, thermal exposure, pressure variation, shaking, intensive vibration treatment followed by dilutions, vortexing, bubble generation, inter alia.The aim of the present review article is to summarize the available data on how the above processes affect the physicochemical and biological properties of water and aqueous solutions.Results. It has been shown that heating makes water less compressible and decreases air solubility in water, while cooling enhances its viscosity. Acoustic exposure makes the structure of water become coarse-grained, followed by an increase the number of large clusters, pH and temperature inside a cavitation bubble. High pressure enhances the viscosity, self-diffusion, and compressibility of water. For bubble processed water, there are changes in the spin-spin and spin-lattice relaxation times. Reactive oxygen species are formed, as well as increased solubility of gases in liquids and reduced friction. Vortex process technology causes an increase of electrical conductivity of water and reduced viscosity. Intensive vibration treatment and dilution processes result in changes in electrical conductivity of water, dissolved gas concentration, ultrasonic wave velocity, рН, surface tension, dielectric constant, and spectral response. There is also data to support the biological effects of different types of physical treatment of solutions.Conclusions. This review shows that physical treatment of water can induce changes both in physicochemical and biological properties of water and aqueous solutions.
KARAKTERISTIK TENAGA KERJA INDONESIA MENJELANG ERA BONUS DEMOGRAFI
Authors: Heryani  , Siagian Tiodora Hadumaon 
Published: November 2023

Jumlah penduduk Indonesia hasil sensus penduduk 2020 sejumlah 275 juta jiwa. Sebesar 62,28 persen merupakan penduduk usia produktif. Pada penelitian ini akan dikaji terkait puncak bonus demografi tersebut dengan karakteristik tenaga kerja. Dengan menggunakan data Badan Pusat Statistik akan di analisis secara deskriptif dan disajikan dalam bentuk tabel dan grafik. Penduduk usia produktif di Indonesia lebih dari 90 persen adalah penduduk yang bekerja. Penduduk tersebut merupakan penduduk yang pendidikan tertingginya sekolah dasar kebawah. Hal ini akan menjadi ancaman bagi Indonesia dalam menyongsong puncak bonus demografi yang diperkirakan akan terjadi pada tahun 2030. Tidak hanya pendidikan tenaga kerja yang rendah, lapangan usaha di dominasi pada sektor pertanian dengan status berusaha sendiri. Fenomena ini selaras dengan karakteristik penduduk miskin Indonesia. Penduduk miskin Indonesia lebih dari 50 persen pendidikan yang ditamatkan adalah sekolah dasar kebawah. Selain itu sumber penghasilan utamanya berasal dari sektor pertanian. Untuk mengatasi hal tersebut bukanlah solusi jika mereka yang berpendidikan dasar kebawah dipaksa untuk melanjutkan pendidikan formalnya. Tetapi bisa diberikan pelatihan dan kursus yang dapat meningkatkan keahlian mereka. Pemerintah juga perlu memperbanyak lapangan kerja bagi penduduk Indonesia.
DETERMINAN SOSIAL EKONOMI KEJADIAN STUNTING
Authors: Maulia Siti Mukharohmah  , Mulyaningsih Tri , Wiyono Vincentius Hadi 
Published: November 2023

Kabupaten Sragen adalah salah satu daerah dengan fokus pengentasan stunting di Indonesia. Pada tahun 2022 rata-rata prevalensi balita stunting di Kabupaten Sragen yakni sebesar 24,3% dimana angka tersebut lebih tinggi dibandingkan dengan rata-rata prevalensi balita stunting di Jawa Tengah (20,8%) dan juga rata-rata nasional (21,6%) (SSGI Kemenkes RI, 2022). Berbagai upaya telah dilakukan pemerintah untuk mencegah anak stunting, namun prevalensi anak stunting di Kabupaten Sragen masih sangat tinggi sehingga diperlukan inovasi kebijakan untuk mempercepat penurunan angka stunting. Penelitian ini bertujuan untuk mengetahui determinan sosial ekonomi terhadap kejadian stunting di Desa Wonorejo. Penelitian ini menggunakan data primer dengan metode pengumpulan data melalui survey dan wawancara. Teknik pengambilan sampel menggunakan systematic random sampling, data kemudian dianalisis dengan menggunakan metode deskriptif kuantitatif dan regresi logistik. Hasil penelitian diperoleh 73 sampel, dimana 21 rumah tangga (28,76%) memiliki anak dengan status gizi stunting. Prevalensi anak stunting lebih tinggi pada anak-anak dengan ibu yang memiliki pendidikan di bawah SMP, ibu yang tidak bekerja, pendapatan per kapita rendah serta anak dengan jenis kelamin laki-laki. Berdasarkan temuan ini, diperlukan intervensi yang tepat dan efektif sesuai dengan faktor penentu anak stunting.
STRATEGI PENGUATAN PERAN KELEMBAGAAN DESA DALAM PENINGKATAN KETAHANAN PANGAN DI DESA KENDALBULUR, KABUPATEN TULUNGAGUNG
Authors: Irawati Riya Irawati , Ginting Reza Pirgianta , Rahayu Neneng Sri 
Published: November 2023

Kabupaten Tulungagung berdasarkan indeks ketahanan pangan komposit termasuk dalam klasifikasi baik atau sangat tahan terhadap kerentanan. Namun masih terdapat permasalahan dalam kelembagaan Desa Kendalbulur, diantaranya kurangnya sumber daya manusia di bidang pemerintahan desa. Penelitian ini bertujuan untuk menggambarkan peran kelembagaan desa dalam mengelola ketahanan pangan dan strategi penguatan kelembagaan. Metode pengumpulan data dilakukan dengan telaah dokumen, wawancara, dan pengamatan di lapangan. Analisis yang dilakukan meliputi analisis potensi desa, kelembagaan pemerintah desa, pengelolaan anggaran desa, regulasi, pengembangan desa, otonomi desa, dan strategi penguatan peran kelembagaan desa dalam meningkatkan ketahanan pangan menggunakan instrument SWOT dan matriks IFAS-EFAS. Hasil penelitian ini menunjukkan peran kelembagaan desa dalam mengelola ketahanan pangan sangat penting. Lebih lanjut, strategi penguatan peran kelembagaan Desa Kendalbulur dalam meningkatkan ketahanan pangan yaitu Rapid Growth Strategy. Oleh karena itu Desa Kendalbulur perlu konsisten mengimplementasikan regulasi dan dukungan kelembagaan yang ada dalam peningkatan pertanian dan budidaya perikanan serta memaksimalkan potensi pertanian, perikanan, peternakan dan wisata.
Pol&iacute;ticas que promueven la justicia ambiental en Argentina: Participiaci&oacute;n comunitaria en la protecci&oacute;n de bosques
Authors: Figueroa Lucas Martín 
Published: November 2023

Abstract: Policies that promote environmental justice in Argentina: Community participation in forest protection
In light of the historical inequalities that indigenous and peasant communities have suffered, the increasing economic pressure over their territories, and considering the emergency of environmental policies in the region, this paper asks, how the participation of indigenous and peasant communities can contribute to the implementation of policies that seek to promote the environmental justice? I compare the implementation of the Native Forest National Law in two Argentinian provinces (Chaco and Santiago del Estero) between 2008 and 2019. The results show that the implementation of the National Forest Law has been successful in reducing deforestation in Santiago del Estero, where indigenous and peasant communities were more protagonists, than in Chaco, where they have not been considered by the provincial authorities.
Resumen

Frente a las históricas desigualdades que han sufrido las comunidades indígenas y campesinas, ante el aumento de la presión económica sobre sus territorios desde comienzos del presente siglo y considerando la emergencia de distintas políticas ambientales en la región, este trabajo se pregunta ¿de qué manera la participación de comunidades indígenas y campesinas contribuye en la implementación de políticas (regionales o nacionales) que buscan promover la justicia ambiental? Para dar respuesta a este interrogante, se compara la implementación de la Ley Nacional de Bosques Nativos en dos provincias argentinas (Chaco y Santiago del Estero) entre 2008 y 2019. Los hallazgos muestran que la Ley Nacional de Bosques Nativos tuvo mayor éxito en reducir la deforestación en Santiago del Estero donde las comunidades indígenas y campesinas tuvieron mayor participación en la aplicación de la normativa en comparación con Chaco en donde no fueron contempladas por las autoridades provinciales.
Pemberdayaan Keluarga dalam Peningkatan Kesehatan Ibu dan Anak Melalui Pendekatan Continuity of Care (COC) di Desa Penfui Timur
Authors: Kiah Firda Kalzum , Saleh Ummi Kaltsum S , Mau Barbara S. Bere , Risyati Linda 
Published: November 2023

ABSTRAK Penyebab kematian langsung maternal adalah gangguan hipertensi dalam kehamilan, pendarahan obstetrik, komplikasi non-obstetrik, komplikasi obstetrik lainnya, infeksi yang berkaitan dengan kehamilan, dan penyebab lain. Kematian maternal dapat dicegah apabila cakupan pelayanan diimbangi dengan mutu pelayanan secara berkelanjutan yang baik. Desa Penfui Timur memiliki cakupan pemeriksaan kehamilan K4 yang masih dibawah target sebesar 73,9% dan masih ada ibu hamil yang melahirkan dirumah. Tujuan yaitu melakukan penyuluhan dan mengevaluasi pelayanan kebidanan berkelanjutan pada ibu hamil. Kegiatan yang dilakukan adalah penyuluhan tentang pelayanan kehamilan, persalinan, nifas, bayi dan KB, serta evaluasi pelayanan kebidanan berkelanjutan pada ibu hamil. Hasil evaluasi menunjukkan peserta mengalami peningkatan pengetahuan dan ibu-ibu telah memanfaatkan pelayanan kebidanan secara berkelanjutan. Kata Kunci: Pemberdayaan, Kesehatan Ibu dan Anak, COC ABSTRACT Direct maternal causes of death are hypertensive disorders in pregnancy, obstetric bleeding, non-obstetric complications, other obstetric complications, pregnancy-related infections, and other causes. Maternal deaths can be prevented if the coverage of services is balanced with good quality of sustainable care. East Penfui Village has K4 pregnancy check coverage which is still below the target of 73.9% and there are still pregnant women who give birth at home. The purpose is to conduct counseling and evaluate sustainable midwifery services for pregnant women. The activities carried out were counseling on pregnancy, childbirth, postpartum, infant and family planning services, as well as evaluation of continuous midwifery services for pregnant women. The evaluation results showed that participants had increased knowledge and mothers had used midwifery continuity of cares. Keywords: Empowerment, Maternal and Child Health, COC