bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of marine hydraulic structures under seismic effects
Authors: Aslanov Latif F. , Aslanli Ulvi L. 
Published: December 2023

Abstract
A new era of development in the oil and gas sector of Azerbaijan, started from the moment of signing a contract with the world's leading oil companies, predetermines the intensive design and construction of new and modernization of existing oilfield facilities. The development of new oil and gas fields at great depths (Н≥500m) is largely associated with the construction of flexible hydraulic structures, one of the main features of which is their affiliation with flexible structures, which determines the need for dynamic calculations when designing for the joint effects of seismic, taking into account the load from waves, wind, currents. On the other hand, it is known that the Caspian region is a seismically active zone, which confirms the latest seismic disturbances with the epicenter in the Caspian Sea. This puts more stringent and high requirements for the calculation of seismic resistance and seismic resistance of such important, and one might say, strategic objects as offshore fixed platforms. Thus, it is possible to determine the seismic stresses for a given movement for each block support, taking into account the physical and mechanical properties of the soil and the depth of the foundation. During the study, earthquakes that occurred in the region were analyzed and their accelerograms were used as input data. The applied analytical methods in solving boundary value problems and the numerical implementation of analytical solutions give accurate results. On the basis of the conducted research and in-depth analysis of the data, the following were determined: the influence of the deck load on seismic stability; the internal forces of multi-tiered structures with various elements of diaphragms were calculated; calculation models of platforms were selected, both for the drilling phase and for the production phase; the dynamic characteristics of deep-water platforms in the vertical direction were modeled; seismic load distributions in elements of offshore platforms are calculated; computer programs have been developed for calculating the support block.
Patients with acute poisoning in Emergency Department – Presentation of modern data search and results of pilot analysis
Authors: Uslin Veronika , Hällberg Ville , Lukkarinen Timo , Niskanen Marjo , Koivistoinen Teemu , Palomäki Ari 
Published: December 2023

Abstract
Background
When studying Emergency Department (ED) visits due to intoxications, it is essential to have comprehensive and accurate baseline data. Electronic health record systems of hospitals provide a good basis for retrospective studies. However, many intoxication patients arriving at the ED may not be identified retrospectively if only one single search method is applied, such as reason for attending, laboratory findings, or International Classification of Diseases (ICD-10) code.
Methods
In this single centre study, a novel four-way combined patient search method was used to retrospectively identify intoxication patients attending the ED of Kanta-Häme Central Hospital, Finland, in 2019. The search included reason for attending, laboratory results related to intoxication diagnostics, ICD-10 codes, and a novel free word search in the patient records. After the automated search, the researcher read the medical records of potential intoxication patients to form comprehensive profiles and to exclude irrelevant cases.
Results
When retrospectively extracting patient data from electronic hospital records, addition of a free word search identified 36% more intoxication patients than the combination of the three methods listed above. The leading substances causing intoxication were ethanol and benzodiazepines, followed by prescription and over-the-counter medications, such as antidepressants and paracetamol. Amphetamine was the most used illegal substance.
Conclusion
Free word search complemented and, in many ways, replaced traditional patient search methods, such as ICD-10 code search. These results highlight the importance of a combined patient search method for retrospective data collection.
Associations Between Over-the-Counter Analgesics Usage and Symptoms of Anxiety and Depression in Adolescents: A Network Analysis
Authors: Roalsø Elise Solbu , Klonteig Sandra , Kraft Brage , Skarstein Siv , Aalberg Marianne , Jonassen Rune 
Published: December 2023

Abstract
Background
The use of over-the-counter analgesics (OTCA) is common among adolescents, particularly females. Previous research has linked symptoms of anxiety and depression (AD) with OTCA usage, even after controlling for pain. AD encompasses a wide array of both psychological and physiological symptoms, and little is known about which of these symptoms are most strongly connected to OTCA usage. In the current study we assessed differences in associations between specific AD symptoms and OTCA usage in a large sample of adolescents. Furthermore, we examined whether the associations between AD symptoms and OTCA usage differed across genders.
Method
We included 626,581 participants from the Ungdata survey. AD symptoms were measured with an adapted version of Hopkins Symptom Checklist-10 and the Depression Mood Inventory, while a 5-point scale assessed OTCA usage. Non-regularized partial-correlation networks were constructed to explore conditional dependent relations between the use of OTCA and AD symptoms, including a separate network controlling for symptoms of pain. Gender-specific networks containing all symptoms were created. The networks were visualized and described statistically in terms of edge weights and bridge centrality (bridge expected influence).
Results
OTCA usage demonstrated associations with most AD symptoms, with the strongest links to “sleep problems”, “stiff or tense”, “everything is a struggle” and “suddenly scared”. When including pain symptoms as covariates, OTCA-AD edges weakened, but most edges persisted as significant. The strongest links were observed between OTCA usage and pain symptoms. Key bridging nodes between communities included “headache” and “stiff or tense”. OTCA usage demonstrated higher bridge expected influence in the female network than in the male. Further, “sleep problems” and “hopeless” showed stronger links to OTCA usage among females, whereas “stiff or tense” was more strongly related to OTCA usage among males.
Conclusion
Our study assessed the relationship between OTCA usage and specific symptoms of anxiety and depression in adolescents. Our results indicate that somatic expressions of AD, such as sleep disturbances and tension, displayed stronger associations with OTCA usage than more conventional AD symptoms. This pattern might be even more pronounced in males than females.
DAB2IP maintains intestinal epithelial homeostasis by modulating the DNA replication stress response
Authors: SHANG ZENG-FU , Yu Lan , Lang Yue , Li Ming , Gu Meng-Meng , Newman Ciara , Chen Wei-Min , Story Michael , Chen Benjamin , Davis Anthony , Saha Debabrata 
Published: December 2023

Abstract
The proliferative activity of undifferentiated cells in intestinal crypts is essential for maintaining intestinal homeostasis and facilitating regeneration in response to both pathophysiological conditions and stress. DAB2IP (Disabled homolog 2 interacting protein), a tumor suppressor, plays a crucial role in regulating various oncogenic pathways. Our previous study unveiled that DAB2IP serves as a cell cycle regulator by facilitating PLK1-mediated mitosis progression. In this study, we uncovered a novel DAB2IP function as it mediates the maintenance and regeneration of intestinal epithelial homeostasis in normal conditions and following irradiation (IR)-induced gastrointestinal (GI) injury. Mechanistically, we identified that DAB2IP interacts with the histone acetyltransferase HBO1 and promotes PLK1-mediated phosphorylation of HBO1. This phosphorylation event leads to HBO-directed lysine 14 acetylation on histone 3 (H3K14Ac), the loading of the minichromosome maintenance protein (MCM) complex onto chromatin, progression of DNA replication, and maintenance of genome integrity. Furthermore, we found that ATR regulates Cdk1-mediated phosphorylation of DAB2IP and that phosphorylation of DAB2IP is crucial for the formation and activation of the HBO1-PLK1 complex. Finally, ablating DAB2IP phosphorylation results in increased genomic instability due to incomplete replication of genomic DNA, as shown via the accumulation of anaphase ultrafine bridges and 53BP1 nuclear bodies in the G1 cell cycle phase. Collectively, our findings highlight the regulatory role of DAP2IP in DNA replication-an essential process for maintaining genomic stability and intestinal homeostasis.
Assessment of Alvarado criteria, ultrasound, CRP, and their combination in patients with suspected acute appendicitis: a single centre study
Authors: Tayebi Ali , Olamaeian Faranak , Mostafavi Keihan , khosravi Kasra , tizmaghz Adnan , Bahardoust Mansour , Zakaryaei Alireza , Mehr Daniyal Enayat 
Published: December 2023

Abstract

Background: Acute appendicitis (AA) is one of the most common reasons for visiting the emergency room. The lack of proper diagnosis and rapid treatment of AA may lead to severe complications such as intestinal perforation and increased mortality. This study aimed to evaluate the diagnostic accuracy of the Alvarado criteria, ultrasound, and CRP criteria in comparison with their combined use in patients with suspected AA who presented to the emergency room.
Methods: In this diagnostic accuracy study, 1411 patients with suspected AA who presented to the emergency department of Firoozabadi Hospital affiliated with Iran University of Medical Sciences and underwent appendectomy from October 2019 to October 2021 were examined. Nine hundred eighty-eight patients were enrolled. All patients were assessed using Alvarado, CRP, and ultrasound. The definitive diagnosis of AA was based on pathological findings and was considered the gold standard. Statistical analyses were performed with STATA VER 11.5. The diagnostic accuracy for each group was compared using the Pearson chi-square test. A value of p<0.05 was considered statistically significant.
Results: The mean age was 29.57±13.66 years. The sensitivity and specificity of Alvarado in the diagnostic accuracy of appendicectomy were 75.2% and 61.3% (CI=95%), respectively. The sensitivity of ultrasound and CRP for predicting appendicitis was significantly higher than the Alvarado criteria. The diagnostic accuracy for CRP was significantly higher than ultrasound (64.9% vs. 60.7%, P: 0.003). The diagnostic accuracy of the simultaneous use of Alvarado + CRP and CRP + Ultrasound was significantly higher than that of Alvarado + ultrasound. The sensitivity, specificity, and diagnostic accuracy of the simultaneous use of all three criteria together (Alvarado + Ultrasound + CRP) were estimated to be 94.9%, 25.8%, and 81.5% (CI=95%), respectively, which were significantly higher than the use of other criteria.
Conclusion: This study showed that the Alvarado criteria had inadequate diagnostic sensitivity and accuracy for diagnosing acute appendicitis. The diagnostic accuracy of acute appendicitis increases to over 90% using the three Alvarado, ultrasound, and CRP criteria at the same time.
Are all high-volume surgeons equally good outcome? A survival analysis of patients with oral cavity squamous cell carcinoma in relation to surgical margin status based on propensity score matching analysis
Authors: Kang Chung-Jan , Wen Yu-Wen , Chien Chih-Yen , Lee Shu-Ru , Ng Shu-Hang , Lee Li-Yu , Lin Jin-Ching , Wang Cheng Ping , Terng Shyuang-Der , Hua Chun-Hung , Chen Tsung-Ming , Chen Wen-Cheng , Tsai Yao-Te , Tsai Chi-Ying , Lin Chien-Yu , Fan Kang-Hsing , Wang Hung-Ming , Hsieh Chia-Hsun , Yeh Chih-Hua , Lin Chih-Hung , Tsao Chung-Kan , Cheng Nai-Ming , Fan Tuan-Jen , Huang Shiang-Fu , Lee Li-Ang , Fang Ku-Hao , Wang Yu-Chien , Lin Wan-Ni , Hsin Li-Jen , Yen Tzu-Chen , Liao Chun-Ta 
Published: December 2023

Abstract
Background
In this retrospective study, we assessed whether Taiwanese high-volume surgeons performing oral cavity squamous cell carcinoma (OCSCC) removal may differ in terms of margin status, and examined how this variable – as a quality standard – could have an impact on clinical outcomes after adjustment for clinicopathological risk factors and treatment modalities.
Methods
On analyzing a nationwide dataset, margins < 5 mm (including positive margins) were identified in 49.5% (6927/13984) of patients with OCSCC. We subsequently identified the surgeon with the highest absolute volume (number of operated patients = 560), who was located below the mean value (49.5%). Among surgeons above the mean, we identified the two surgeons with the highest volumes (termed as Surgeon 2 and Surgeon 3). The number of patients and survival operated by Surgeon 2 and Surgeon 3 were similar (number 229 and 221, respectively, totaling 450 patients; 5-year overall survivals [OSs] 64% and 65%, respectively) and thus they were grouped together for the purpose of analysis (Surgeons 2–3).
Results
The patient proportion of margins ≥ 5 mm was markedly higher in Surgeon 1 than Surgeons 2 − 3 (75.4% and 22.5%, respectively). Compared to Surgeons 2 − 3, the tumor severity was higher in Surgeon 1 (mainly a higher frequency of pT4a status, p-Stage IV, and poorly differentiated tumor). The clinical outcomes of patients treated by Surgeon 1 were more favorable than those treated by Surgeons 2 − 3 and these survival differences were even more pronounced after adjusting for baseline differences using propensity score matching (before propensity score: disease-specific survival [DSS], 83%/70%, p < 0.0001; OS, 77%/64%, p < 0.0001; after propensity score: DSS, 87%/68%, p < 0.0001; OS, 81%/63%, p < 0.0001). When patients were stratified according to the operating surgeon and margin status, we found that Surgeon 1 consistently outperformed Surgeons 2 − 3 in terms of clinical outcomes, regardless of surgical margin status (i.e., ≥ 5 mm, < 5 mm, and positive margins).
Conclusions
We conclude that the achievement of clear margins (≥ 5 mm) is a surgeon-dependent variable which is not necessarily related to hospital and/or surgeon volumes, therefore surgeons should strive to achieve adequate margins to optimize survival in OCSCC.
g-C3 N4 /N-doped CeO2 nanocomposites as effective dye catalyst: Fabrication, characterization and methylene blue dye degradation
Authors: Sekar Karthik Arasampatti , Sengodan Senthil 
Published: December 2023

Abstract
A New series of g-C3N4/N-doped CeO2 nanocomposites(g-C3N4/N-doped CeO2NCs) were prepared by using a simple dispersion method and its efficacy towards the photocatalytic activity has been studied. photocatalytic degradation of an organic dye(methylene blue) using the synthesized nanocomposites has been carried out. A detailed material characterization of fabricated g-C3N4/N-CeO2 NCs was also performed, including crystallinity, surface properties, band gap energy, excitation electron property, and chemical interaction analysis. The study reveals that coupling of g-C3N4/N-doped CeO2NCs improved the photocatalytic activity by diminishing the optical band gap energy of 2.85 eV of N-doped CeO2 photocatalyst. Furthermore, the g-C3N4/N-CeO2NCs exhibited an improved photocatalytic efficiency of methylene blue (MB) degradation viz., 97% while comparing the native form of N-doped CeO2 nanoparticles and g-C3N4 which showed 40% and 32% (60 min) efficiency respectively. This improvement in the efficiency of photocatalytic activity of g-C3N4/N-CeO2NCs may be ascribed to the strong electron transport abilities of g-C3N4 layers that could separate electron-hole pairs effectively.
Chitosan modified with PAP as a Promising Delivery System for Melatonin in the Treatment of Osteoporosis : Targeting the DMT1
Authors: Zhang Weilin , Rong Hongrui , Liang Jinguo , Mao Chao , Li Zhencong , Dai Zhiwen , Li Dingbin , Guo Weixiong , Chen Siyuan , Wang Zhongwei , Wei Jinsong 
Published: December 2023

Abstract
The demand of novel and efficient therapy gradually increased with the rising concerns of Osteoporosis (OP). The hottest topic to promote bone regeneration under osteoporotic conditions consists of loading bioactive materials with different drugs to treat osteoporotic bone by either promoting the osteogenesis process or inhibiting the activity of osteoclasts. By analyzing the single-cell sequencing results, we found that divalent metal transporter 1 (DMT1) has a function in osteoporosis. Based on our previous research foundation, Melatonin(MT) could suppress DMT1 express induced by high glucose in Osteoporosis. So, we are more determined to choose MT for the treatment of osteoporosis. However, the curative effect of MT in osteoporosis was dissatisfied in clinical. To enhance its biological performance, we combined MT with porous gelatin Chitosan (CS) and conductive material PLA-b-AP-b-PLA (PAP), we investigated how MT incorporation in CS@PAP nanoparticles impacts their ability to promote MC3T3-E1 osteogenesis and mineralization in vitro and vivo. Herein, the present study confirms the effect of MT in DMT1, prepared and explore available on composites prepared as nanofibers characteristics, the efficacy of MT combined CS-PAP modified hydrogels slow release systems in femur model of osteoporosis mice, associated properties found suitable for bone tissue engineering. May present a new strategy for OP patients management. The results indicate that MT-loaded CS@PAP nanospheres shows favorable osteogenic function in vivo and vitro.
Genome of Bifidobacterium longum subsp. infantis YLGB-1496 provides insights into its carbohydrate utilization and genetic stability
Authors: Li Xiaoxia , Yang Jianjun , Shi Shaoqi , Lan Hanglian , Zhao Wen , Hong Weilian , Wang Ran 
Published: December 2023

Abstract
Background
Bifidobacterium longum subsp. infantis YLGB-1496 is a probiotic strain isolated from human breast milk. The application of B. infantis YLGB-1496 is influenced by carbohydrate utilization and genetic stability. This study used genome sequencing to determine the carbohydrate utilization characteristics and genetic stability of YLGB-1496.
Results
The genome sequence of YLGB-1496 consists of 275,8242 bp base pairs, 2442 coding sequences, and a GC content of 59.87%. A comparison of carbohydrate transport and metabolism genes of B. infantis showed that YLGB-1496 was rich in GH13, 20, 25, and 109 gene families. Growth characteristic analysis, scanning electron microscopy, and SNP assays were performed in consecutive subcultures, and it was found that the growth characteristics and fermentation activity of the strain were highly stable. The surface and edges of the 1000th generation strains were progressively smoother and well-defined, with no perforations or breaks in the cell wall. There were 20 SNP loci at the 1000th generation, fulfilling the requirement of belonging to the same strain. The presence of genes associated with cell adhesion and the absence of resistance genes supported the probiotic characteristics of the strain.
Conclusion
This is the report on the whole genome sequence of B. infantis YLGB-1496 isolated from human breast milk of China. The data obtained in this study provide insights into broad-spectrum carbohydrate utilization, genomic stability, and probiotic properties of YLGB-1496, which provide theoretical support to promote the use of YLGB-1496 in infant foods.
A dual role of ERGIC-localized Rabs in TMED10-mediated
unconventional protein secretion
Authors: Ge Liang , Sun Yuxin , Tao Xuan , Han Yaping , Tian Rui , Wang Haodong , Sun Qiming , Zhang Min 
Published: December 2023

Abstract

Cargo translocation into dedicated secretory compartments is a crucial aspect of secretion. In conventional secretion, signal peptide-equipped proteins enter the endoplasmic reticulum (ER), while a subset of cargo lacking signal peptides were found to translocate into the ER-Golgi intermediate compartment (ERGIC) in unconventional protein secretion (UcPS). The regulatory events at the ERGIC in UcPS is unclear. Here we reveal the involvement of ERGIC-localized small GTPases, Rab1s (Rab1A and Rab1B), and Rab2A in regulating UcPS cargo transport via TMED10 on the ERGIC. Rab1s enhance TMED10 translocator activity, promoting cargo translocation into the ERGIC, while Rab2A, in collaboration with KIF5B, regulates ERGIC compartmentalization, establishing a UcPS-specific compartment. This investigation highlights the pivotal role of ERGIC-localized Rabs in governing cargo translocation and specifying the ERGIC's function in UcPS.
Depression, Anxiety or both? Perspectives on Suicidal Ideation in Young People Following Acute Stressful Events
Authors: Wang Hao , Xu Jingzhou , Cui Yi , Su Tong , Xu Shuyu , Xiao Lei , Zhang Ruike , Liu meishan , Cai wenpeng , Tang yunxiang 
Published: December 2023

Abstract
Background: Suicide is the fourth leading cause of death among young individuals, with the number of suicide-related fatalities escalating annually, which gets widespread concern worldwide. A substantial body of evidence suggests that suicidal ideation serve as a crucial predictive factor of suicidal actions. In particular, individuals are vulnerable to develop negative cognitions, suicidal ideation and subsequent suicidal behavior following an acute stressful event. The objective of this study is to examine the correlation between emotions and suicidal ideation in a youthful population before and after a stressful event.
Methods:The psychological status and suicidal ideation of the group were conducted by adopting a whole group sampling method before and after the acute stressful event. The data were analyzed utilizing SPSS Version 26 (IBM, Illinois, USA), including the Spearman correlation analysis, meditating effect analysis, the binary logistic regression analysis.
Results: The findings demonstrated that individuals with suicidal ideation exhibited higher levels of stress perception, depression and anxiety compared to those without suicidal ideation at all times. Comparing to the results of daily screening, the mediating effect of depression between stress and suicidal ideation was significantly more pronounced (53.11% - 79.66%) in the group following the stressful event, while the mediating effect of anxiety was smaller (33.48% - 31.03%). Logistic regression analysis revealed that depression subsequent to a stressful event increased the risk of suicidal ideation (OR: 1.74). The results of the logistic
regression analysis corroborated the alterations in the mediating effects, suggesting that depression play a more crucial role in prompting suicidal ideation after a stressful event.
Conclusions:The findings offer an enhanced and refined theoretical foundation for both crisis and clinical interventions, providing greater efficacy and specificity.
Waste furniture-derived biofuel production through steam explosion torrefaction
Authors: Lee Joon-Pyo , Park Gwon Woo , Lee Jin-Suk , Lee Hyung-Woo , Jeong So-Yeon , Lee Jae-Won , Min Kyoungseon 
Published: December 2023

Abstract
Bioenergy utilizing carbon-neutral biomass is significant for power generation. For economic feasibility and to avoid food vs. energy issues, various types of waste biomass have been studied as renewable feedstock. Herein, medium-density fiberboard (MDF) and particle board (PB), which are main components of waste furniture, were used for steam explosion torrefaction. The optimum torrefaction conditions were controlled by the severity index (Ro), resulting in an optimum Ro of 3.72 and 4.01 for MDF and PB, respectively. Additionally, steam explosion torrefied MDF and PB were suitable for Bio-Solid Refuse Fuel (SRF) quality standard, thereby indicating that steam explosion-torrefied MDF and PB can use for solid-type biofuel. This is the first report presenting the potential of waste furniture as a biofuel source for power generation. The results provide insights on the valorization of municipal waste (e.g., waste furniture) and suggest strategies to address recent climate crisis by providing solutions for waste management.