bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten-year outcomes of anterior cruciate ligament reconstruction with hamstring tendon autograft and femoral fixation with a cortico-cancellous screw suspension device
Authors: Senigagliesi Elisa , Farinelli Luca , Aquili Alberto , Canè Pier Paolo , Fravisini Marco , Gigante Antonio Pompilio 
Published: September 2023

Abstract
Purpose
To evaluate the clinical and radiographic outcomes of anterior cruciate (ACL) reconstruction at minimum 10-year follow-up.

Methods
Ninety-three patients who underwent primary unilateral ACL reconstruction with hamstring tendon autograft, transtibial technique and femoral cortico-cancellous screw suspension device (Athrax, Leader Medica s.r.l) between 2010 and 2012 were retrospectively reviewed. Mean follow-up was 136 months. Evaluation was performed using the International Knee Documentation Committee score (IKDC), Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score and Tegner Activity Level Scale. Incidence of OA was determined by comparing standard anteroposterior and lateral weightbearing radiographs of the ACL-reconstructed and contralateral knee. Osteoarthritis severity was graded according to the Kellgren–Lawrence (KL) score.

Results
Median Tegner activity level was 6 (5–7). Lysholm and IKDC scores were 100 (95–100) and 90 (86–95), respectively, KOOS was 98 (95–100). Of ACL-reconstructed knees, 41 (50%) had radiographic OA, of which 6 (7.3%) had severe OA (KL III). Of the contralateral healthy knees, 28 (34.1%) had radiographic evidence of OA. Of these 22 (26.8%) and 6 (7.3%) patients had, respectively, KL-I and KL-II. 11 patients (11.8%) underwent subsequent knee surgery: 5 (5.4%) revisions, 3 (3.2%) meniscal surgeries, 2 (2.2%) other surgeries, 1 (1.1%) contralateral ACL reconstruction.

Conclusions
The study demonstrates that ACL reconstruction with HT autograft and cortico-cancellous screw suspension device determines satisfying clinical results after 10 years of follow-up. From our cohort, a low rate of graft failure has been reported, even though almost 50% of patients present a knee OA greater or equal to grade II KL.
Viscous and thermal velocity slip coefficients via the linearized Boltzmann equation with ab initio potential
Authors: Basdanis Thanasis , Valougeorgis Dimitris , Sharipov Felix 
Published: September 2023

AbstractThe viscous and thermal velocity slip coefficients of various monatomic gases are computed via the linearized classical Boltzmann equation, with ab initio potential, subject to Maxwell and Cercignani–Lampis boundary conditions. Both classical and quantum interatomic interactions are considered. Comparisons with hard sphere and Lennard–Jones potentials, as well as the linearized Shakhov model are performed. The produced database is dense, covers the whole range of the accommodation coefficients and is of high accuracy. Using symbolic regression, very accurate closed form expressions of the slip coefficients, easily implemented in the future computational and experimental works, are deduced. The thermal slip coefficient depends, much more than the viscous one, on the intermolecular potential. For example, in the case of diffuse scattering, the relative differences in the viscous slip coefficient data between HS and AI potentials are less than 4%, whilst the corresponding ones in the thermal slip coefficient data are about 6% for He, reaching 15% for Xe. Quantum effects are considered for He, at temperatures 1–104 K to deduce that deviations from the classical behaviour are not important in the viscous slip coefficient, but they become important in the thermal slip coefficient, where the differences between the classical and quantum approaches reach 15% at 1 K. The computational effort of solving the linearized Boltzmann equation with ab initio and Lennard–Jones potentials is the same. Since ab initio potentials do not contain any adjustable parameters, it is recommended to use them at any temperature.
New ethnographic perspective on relational ethics in the field of Artificial intelligence
Authors: Pavlović Pavle , Hafner Fink Mitja 
Published: September 2023

AbstractThis article was created on the wave of the ubiquitous and already-saturated topic of ethics in the field of artificial intelligence. We were motivated by the proliferation of rules within this field and by a posthumanism critique of this topic. We attempt to nurture a new research platform for a social science analysis of the “How of ethics” issue by providing an argument for the study of algorithms and ethical issues by expanding the usability of the concept of niche construction and environmental perspectives in ethnographic studies. From a design perspective, this means expanding the quest related to the ethical matter by intensifying the inquiry in a design that includes not just the design process but also a more comprehensive environment. Inspired by current trends in evolutionary anthropology, science studies, and the philosophy of science, we are in line with approaches that reaffirm ethical issues from standpoint theory in the current scientific debate about trust in science. The results of our historical perspective on the issue of value neutrality point out that the position where the tool is not neutral does not mean that it is biased but that it is deeply involved in the network of relationships that influence it to be biased, and that threatens its autonomy. By providing argumentation based on the issue of ethics, we have nurtured the so-called ecology of practice and connoisseurs as a new practice and perspective that ethnography can take on the issue of accountable, ethical, and trustable science.
Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
Authors: Elblehi Samar S. , Hafez Mona H. , El-Far Ali H. 
Published: September 2023

AbstractCypermethrin (CYP) is a synthetic pyrethroid utilized as an insecticide in agriculture and various pest eradication programs. However, it induces numerous health hazards for animals and humans. Therefore, the current study used Panax ginseng root extract (ginseng) to reduce the hepatorenal damage caused by commercially used CYP. Thirty-two male Wistar albino rats were distributed into control, ginseng (300 mg/kg B.W/day), CYP (4.67 mg/kg B.W.), and Ginseng+CYP (rats received both CYP and ginseng). All treatments were administered orally for 30 consecutive days. Cypermethrin induced harmful effects on hepatic and renal tissues through a substantial decline in body weight in addition to a considerable increase in liver enzymes, functional renal markers, and cholesterol. Also, CYP significantly decreased acetylcholinesterase (AChE) activity and increased pro-inflammatory cytokines (interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α)). Moreover, a marked increase in malondialdehyde level with a significant drop in reduced glutathione level and total superoxide dismutase (T-SOD) and catalase (CAT) activities was reported in the CYP group in kidney and liver tissues. Additionally, CYP exhibited affinities to bind and inhibit AChE and antioxidant enzymes (T-SOD and CAT) in rats following the molecular docking modeling. The apparent hepatorenal oxidative damage was linked with obvious impairments in the liver and kidney histoarchitecture, immunohistochemical staining of B cell lymphoma-2 (Bcl-2), and caspase-3 proteins. Ginseng reduced CYP’s oxidative alterations by repairing the metabolic functional markers, improving antioxidant status, reducing the inflammatory response, and enhancing the molecular docking evaluation. It also ameliorated the intensity of the histopathological alterations and improved the immunohistochemical staining of Bcl-2 and caspase-3 proteins in the liver and kidney tissues. Finally, concomitant oral administration of ginseng mitigated CYP-prompted hepatorenal damage through its antioxidant, anti-inflammatory, and anti-apoptotic potentials.
Graphical Abstract
CO2 emissions in Latin America: a time series perspective based on fractional integration
Authors: Asturias-Schaub Luis Rodrigo , Gil-Alana Luis Alberiko 
Published: September 2023

AbstractThis article deals with the analysis of $${\mathrm{CO}}_{2}$$

CO
2

emissions in Latin America by using a long memory process based on fractional integration. Using data of $${\mathrm{CO}}_{2}$$

CO
2

emission and $${\mathrm{CO}}_{2}$$

CO
2

emissions per capita, for 32 Latin American and Caribbean countries, the results show significant differences according to the variable examined, the model used, and the country under examination. In particular, for the $${\mathrm{CO}}_{2}$$

CO
2

emissions, mean reversion is found in Belize and also under some circumstances in Antigua and Barbuda, Colombia, Dominica, Dominican Republic, Ecuador, Grenada, Honduras, Nicaragua, Panama, Peru, and Uruguay. Thus, shocks in these series have a transitory effect. With respect to the time trends, only for some Caribbean countries, namely, Antigua and Barbuda, Aruba, Bahamas, Cuba, and Jamaica, the trend is insignificant; on the other hand, large countries like Brazil, Mexico, and Argentina display the highest time trend coefficients; for the $${\mathrm{CO}}_{2}$$

CO
2

emissions per capita, there are eleven countries where mean reversion is detected, and there are ten that share a lack of significance for the trend. The most significant trends now take place in Trinidad and Tobago, British Virgin Islands, Barbados, and Guyana. Policy implications of the results obtained are reported at the end of the paper.
Accumulation and contamination of gully pot sediments from varied land-use types: metal loads, concentrations and speciation
Authors: Gavrić Snežana , Flanagan Kelsey , Wei Haoyu , Österlund Heléne , Lundy Lian , Viklander Maria 
Published: September 2023

AbstractUrban stormwater typically enters sewer networks through gully pots, which allow a primary sedimentation of solids upstream of the piped network. The regular removal and disposal of retained sediment are necessary, costly and can involve environmental risks due to the contamination of sediments with substances from the urban environment such as metals. The concentrations and speciation of Cd, Cr, Cu, Ni, Pb and Zn were analysed in sediments from 26 gully pots located in different land use areas in Stockholm, Sweden. In addition, accumulation rates of both sediment and metal masses were evaluated, providing a basis for optimising maintenance practices and better understanding of impacts of characteristic urban land use types. Metal concentrations varied by at most a factor of eight between samples and were always below Swedish polluted site guidelines for less sensitive land use, with only eight samples exceeding the guideline values for Cu and Zn for sensitive land use. Sequential extraction showed Pb and Zn to be the most mobile metals. Sediment accumulation rates varied from 0.003 to 0.197 kg/m2 impermeable surface/year. Metal accumulation rates were much more variable than metal concentrations, with a factor of up to 172 between the highest and lowest rates and the highest metal accumulation rates corresponding to the lower range of mass loads in road runoff. Differences in metal concentrations, sediment or metal mass accumulations could not be solely attributed to either traffic or catchment land use. In contrast, traction grit used for winter road maintenance, which has low (but detectable) metal concentrations, is identified as a major component of gully pot sediments, with a combined effect of both moderating metal concentrations and contributing to total mass.
Balanced scorecard: trends, developments, and future directions
Authors: Kumar Satish , Lim Weng Marc , Sureka Riya , Jabbour Charbel Jose Chiappetta , Bamel Umesh 
Published: September 2023

AbstractBalanced scorecard (BSC) is widely studied and practiced. As research on the BSC has matured since its introduction in 1992, it is timely to assess its progress and outline future directions. This study synthesizes extant research and presents avenues to advance the BSC. To accomplish these objectives, we undertake a review employing a bibliometric and systematic methodology on a corpus of 1294 BSC-related studies. The review reveals that the more than 30-year history of BSC research has followed a bell-curve trajectory, with publications appearing in high-quality, multidisciplinary journals and contributions from numerous author groups worldwide. Moreover, the review highlights the evolution of major themes and topics on the BSC, encompassing customer orientation, financial management, integrated reporting, strategic performance management, sustainable development, and systems thinking. Sustainability BSC has also gained prominence due to sustainability firmly establishing itself as a global agenda and grand challenge. Taken collectively, this review serves as a one-stop resource for gaining a state-of-the-art understanding of the trends, developments, and future directions of the BSC.
Local interactions affect spread of resource in a consumer-resource system with group defense
Authors: Arroyo-Esquivel Jorge , Hastings Alan , Baskett Marissa L. 
Published: September 2023

AbstractIntegrodifference equations are a discrete-time spatially explicit model that describes the dispersal of ecological populations through space. This framework is useful to study spread dynamics of organisms and how ecological interactions can affect their spread. When studying interactions such as consumption, dispersal rates might vary with life cycle stage, such as in cases with dispersive juveniles and sessile adults. In the non-dispersive stage, resources may engage in group defense to protect themselves from consumption. These local nondispersive interactions may limit the number of dispersing recruits that are produced and therefore affect how fast populations can spread. We present a spatial consumer-resource system using an integrodifference framework with limited movement of their adult stages and group defense mechanisms in the resource population. We model group defense using a Type IV Holling functional response, which limits the survival of adult resource population and enhances juvenile consumer production. We find that high mortality levels for sessile adults can destabilize resource at carrying capacity. Furthermore, we find that at high resource densities, group defense leads to a slower local growth of resource in newly invaded regions due to intraspecific competition outweighing the effect of consumption on resource growth.
Leveraging Digital Health to Improve the Cardiovascular Health of Women
Authors: Azizi Zahra , Adedinsewo Demilade , Rodriguez Fatima , Lewey Jennifer , Merchant Raina M. , Brewer LaPrincess C. 
Published: September 2023

Abstract
Purpose of Review
In this review, we present a comprehensive discussion on the population-level implications of digital health interventions (DHIs) to improve cardiovascular health (CVH) through sex- and gender-specific prevention strategies among women.

Recent Findings
Over the past 30 years, there have been significant advancements in the diagnosis and treatment of cardiovascular diseases, a leading cause of morbidity and mortality among men and women worldwide. However, women are often underdiagnosed, undertreated, and underrepresented in cardiovascular clinical trials, which all contribute to disparities within this population. One approach to address this is through DHIs, particularly among racial and ethnic minoritized groups. Implementation of telemedicine has shown promise in increasing adherence to healthcare visits, improving BP monitoring, weight control, physical activity, and the adoption of healthy behaviors. Furthermore, the use of mobile health applications facilitated by smart devices, wearables, and other eHealth (defined as electronically delivered health services) modalities has also promoted CVH among women in general, as well as during pregnancy and the postpartum period. Overall, utilizing a digital health approach for healthcare delivery, decentralized clinical trials, and incorporation into daily lifestyle activities has the potential to improve CVH among women by mitigating geographical, structural, and financial barriers to care.

Summary
Leveraging digital technologies and strategies introduces novel methods to address sex- and gender-specific health and healthcare disparities and improve the quality of care provided to women. However, it is imperative to be mindful of the digital divide in specific populations, which may hinder accessibility to these novel technologies and inadvertently widen preexisting inequities.
RNA-Binding Proteins: A Role in Neurotoxicity?
Authors: Ocharán-Mercado Andrea , Loaeza-Loaeza Jaqueline , Castro-Coronel Yaneth , Acosta-Saavedra Leonor C. , Hernández-Kelly Luisa C. , Hernández-Sotelo Daniel , Ortega Arturo 
Published: September 2023

AbstractDespite sustained efforts to treat neurodegenerative diseases, little is known at the molecular level to understand and generate novel therapeutic approaches for these malignancies. Therefore, it is not surprising that neurogenerative diseases are among the leading causes of death in the aged population. Neurons require sophisticated cellular mechanisms to maintain proper protein homeostasis. These cells are generally sensitive to loss of gene expression control at the post-transcriptional level. Post-translational control responds to signals that can arise from intracellular processes or environmental factors that can be regulated through RNA-binding proteins. These proteins recognize RNA through one or more RNA-binding domains and form ribonucleoproteins that are critically involved in the regulation of post-transcriptional processes from splicing to the regulation of association of the translation machinery allowing a relatively rapid and precise modulation of the transcriptome. Neurotoxicity is the result of the biological, chemical, or physical interaction of agents with an adverse effect on the structure and function of the central nervous system. The disruption of the proper levels or function of RBPs in neurons and glial cells triggers neurotoxic events that are linked to neurodegenerative diseases such as spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), fragile X syndrome (FXS), and frontotemporal dementia (FTD) among many others. The connection between RBPs and neurodegenerative diseases opens a new landscape for potentially novel therapeutic targets for the intervention of these neurodegenerative pathologies. In this contribution, a summary of the recent findings of the molecular mechanisms involved in the plausible role of RBPs in RNA processing in neurodegenerative disease is discussed.
Identifying the effectiveness of 3D culture systems to recapitulate breast tumor tissue in situ
Authors: Ludwik Katarzyna A. , Greathouse Frances R. , Han Samuel , Stauffer Kimberly , Brenin David R. , Stricker Thomas P. , Lannigan Deborah A. 
Published: September 2023

Abstract
Purpose
Breast cancer heterogeneity contributes to chemotherapy resistance and decreased patient survival. To improve patient outcomes it is essential to develop a technology that is able to rapidly select the most efficacious therapy that targets the diverse phenotypes present within the tumor. Breast cancer organoid technologies are proposed as an attractive approach for evaluating drug responses prior to patient therapy. However, there remain challenges in evaluating the effectiveness of organoid cultures to recapitulate the heterogeneity present in the patient tumor in situ.

Method
Organoids were generated from seven normal breast and nineteen breast cancer tissues diagnosed as estrogen receptor positive or triple negative. The Jensen-Shannon divergence index, a measure of the similarity between distributions, was used to compare and evaluate heterogeneity in starting tissue and their resultant organoids. Heterogeneity was analyzed using cytokeratin 8 and cytokeratin 14, which provided an easily scored readout.

Results
In the in vitro culture system HER1 and FGFR were able to drive intra-tumor heterogeneity to generate divergent phenotypes that have different sensitivities to chemotherapies.

Conclusion
Our methodology, which focuses on quantifiable cellular phenotypes, provides a tractable system that complements omics approaches to provide an unprecedented view of heterogeneity and will enhance the identification of novel therapies and facilitate personalized medicine.
Multilevel Monte Carlo FEM for elliptic PDEs with Besov random tree priors
Authors: Schwab Christoph , Stein Andreas 
Published: September 2023

AbstractWe develop a multilevel Monte Carlo (MLMC)-FEM algorithm for linear, elliptic diffusion problems in polytopal domain $${\mathcal {D}}\subset {\mathbb {R}}^d$$

D
⊂

R

d

, with Besov-tree random coefficients. This is to say that the logarithms of the diffusion coefficients are sampled from so-called Besov-tree priors, which have recently been proposed to model data for fractal phenomena in science and engineering. Numerical analysis of the fully discrete FEM for the elliptic PDE includes quadrature approximation and must account for (a) nonuniform pathwise upper and lower coefficient bounds, and for (b) low path-regularity of the Besov-tree coefficients. Admissible non-parametric random coefficients correspond to random functions exhibiting singularities on random fractals with tunable fractal dimension, but involve no a-priori specification of the fractal geometry of singular supports of sample paths. Optimal complexity and convergence rate estimates for quantities of interest and for their second moments are proved. A convergence analysis for MLMC-FEM is performed which yields choices of the algorithmic steering parameters for efficient implementation. A complexity (“error vs work”) analysis of the MLMC-FEM approximations is provided.
The short- and long-term properties of welded high-temperature-resistant thermoplastics
Authors: Vogtschmidt Sascha , Schoeppner Volker 
Published: September 2023

AbstractHigh-performance plastics, such as polyphenylene sulfide or polyphthalamide, are increasingly being used in highly stressed areas, primarily due to their outstanding thermal and mechanical properties. Due to the increasing demands on plastic components in terms of geometry, functional integration, etc., components produced by primary molding often have to be welded in an additional process step. Furthermore, there are often restrictions with regard to component cleanliness, which is why converting, non-contact welding processes are of great industrial interest. However, as a result of the changeover-step in these processes, the previously plasticized areas cool down. For materials with high melt temperatures this circumstance can lead to inadequate weld seam qualities.The aim of the investigations was therefore to expand the understanding of the process of welding high-temperature-resistant plastics, to identify optimum welding parameters and to determine the mechanical short- and long-term properties of the welds. Furthermore, a comparison was made between the changeover welding processes and single-stage vibration welding in order to clarify the relevance of short changeover times.It could be shown that a significant correlation exists between the changeover time, the melting temperature and the resulting weld strength. Furthermore, the selection of the welding process and thus the type of heat input seems to have an influence on the long-term properties of the welds at high test temperatures.