bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels
Authors: Svensson Maria K. , James Stefan , Ravn-Fischer Annica , Villa Guillermo , Schalin Lovisa , Cars Thomas , Gustafsson Stefan , Hagström Emil 
Published: February 2024

Background: Treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors reduces low-density lipoprotein cholesterol (LDL-C) levels and decreases the incidence of major ischaemic events in clinical trials. However, less is known about the efficacy of PCSK9 inhibition in clinical practice. This study aimed to describe the change in LDL-C levels over time and LDL-C goal achievement in patients with/without atherosclerotic cardiovascular disease (ASCVD), who were prescribed evolocumab in clinical practice, and to describe adherence to and persistence with treatment.
Methods: Patients in Sweden with at least one evolocumab prescription filled between July 2015 and May 2020 were included. Medical history and lipid-lowering therapy (LLT) were sourced from national registries. LDL-C levels before and after treatment initiation were assessed using medical records. Persistence with and adherence to evolocumab and oral LLT were assessed up to 12 months after treatment initiation using the refill-gap method and proportion of days covered, respectively.
Results: Of the 2,360 patients with at least one prescription for evolocumab, 2,341 were included; 1,858 had ASCVD. Persistence with (76%) and adherence to (86%) evolocumab were high throughout the 12 months following initiation. Mean LDL-C levels decreased by 53% (95% confidence interval [CI]: 51–55%) in patients adherent to evolocumab (n = 567) and 59% (95% CI: 55–63%) in patients adherent to evolocumab and oral LLT (n = 186). Similar reductions in LDL-C were observed in patients with/without ASCVD. Reduced LDL-C levels remained stable during follow-up. Amongst patients adherent to evolocumab and those adherent to evolocumab and oral LLT, 23 and 55% achieved the LDL-C goal of <1.4 mmol/L, respectively.
Conclusions: The evolocumab LDL-C-lowering effect observed in clinical trials was confirmed in clinical practice in Sweden, particularly in patients also treated with oral LLT. During follow-up, adherence to and persistence with evolocumab were high, with stable reduced levels of LDL-C during observation.
Covid-19 Pandemic and the Green Open Space Concept of Balinese Traditional Community
Authors: Waisnawa I Made Jayadi 
Published: February 2024

Purpose: The purpose of this research was to determine the relationship between the concept of Green Open Space (Ruang Terbuka Hijau/RTH) of traditional Balinese society and the Covid-19 disease.
Methodology: The method used in this research is a literature study which will be presented qualitatively.
Results and duscussion: The meaning of the Green Open Space in the concept of hulu-teben, tri mandala, karang embang, sanga mandala, natah, karang tuang, kahyangan tiga and setra is an effort to minimize interactions that threaten the harmony of nature.
Implication: The dominant spread of the virus in closed spaces can also be minimized through the concept of structuring the Green Open Space, both on a residential and public scale.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN BERKEMIH JONGKOK PADA PRIA DEWASA
Authors: Astuti Anita , Astuti Anita 
Published: February 2024

Banyak pria dewasa tidak berkemih jongkok karena berbagai alasan seperti kebiasaan berkemih berdiri sejak usia dini dan karena jenis toilet. Studi pendahuluan di Lingkungan Graha Kelurahan Urung Kompas diketahui bahwa keluhan perkemihan pada pria dewasa meliputi urin yang terputus-putus serta sensasi tidak tuntas saat berkemih. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan berkemih jongkok pada pria dewasa di Lingkungan Graha Kelurahan Urung Kompas Sumatera Utara. Penelitian ini berjenis kuantitatif dengan desain korelasi dan pendekatan yang dilakukan adalah cross sectional. Populasi penelitian ini pria dewasa usia 26 tahun sampai 45 tahun di lingkungan Graha kelurahan Urung Kompas sebanyak 204 jiwa. Sampel penelitian ini 135 orang dengan teknik purposive sampling. Pengumpulan data menggunakan kuesioner yang disebar dengan google form dan langsung. Analisis data dengan analisis univariat dan bivariat menggunakan uji chi-square. Hasil penelitian ini ada hubungan signifikan antara perilaku sosial pria dewasa dengan berkemih jongkok (p = 0,000; OR = 11,200), ada hubungan signifikan antara LUTS dengan berkemih jongkok (p = 0,000; OR = 8,870), ada hubungan signifikan antara pengetahuan ilmu agama dengan berkemih jongkok (p = 0,000; OR = 11,229), dan ada hubungan signifikan antara jenis toilet dengan berkemih jongkok (p = 0,008; OR = 2,716). Disarankan kepada pria dewasa untuk membiasakan berkemih jongkok untuk menjaga kesehatan sistem perkemihan.
HUBUNGAN PENGETAHUAN DAN SIKAP IBU DENGAN PEMBERIAN ASI EKSLUSIF PADA BAYI DI PUSKESMAS PINANGSORI KABUPATEN TAPANULI TENGAH TAHUN 2022
Authors: Batubara Novita Sari , Batubara Rini Amalia 
Published: February 2024

ABSTRACK

Breastfeeding is one of the efforts to improve the nutritional status of children in the First 1000 Days of Birth (FDB). Malnutrition at the age of less than 2 years will have an impact on decreased physical growth, brain development, intelligence, and productivity. These impacts are largely irreversible. Breastfeeding in the world is around 50%. Breastfeeding coverage in Latin America and the Caribbean is 32% and 46 % in the developing countries. The purpose of this study was to determine the relationship between knowledge and attitudes of mothers with exclusive breastfeeding for infants at the Pinangsori Public Health Center, Central Tapanuli District in 2022. The type of research used was quantitative with a cross sectional study approach. The population of the research were all mothers who had babies at the age of 6-12 months who came to the Pinangsori Public Health Center in January-July 2022 about 51 people by using the total sampling method. The analysis used was Chi-square test and the results showed that value of (p = 0.017), which mean that there was a relationship between attitude and exclusive breastfeeding for infants. It is suggested for mothers to dig up information about exclusive breastfeeding for babies as a provision of knowledge. Further, mother can give exclusive breastfeeding for their baby for six months.
ABSTRAK

Pemberian ASI salah satu upaya untuk meningkatkan status gizi anak dalam 1000 Hari Pertama Kelahiran (HPK). Gizi kurang pada usia kurang dari 2 tahun akan berdampak terhadap penurunan pertumbuhan fisik, perkembangan otak, kecerdasan, dan produktivitas; dampak ini sebagian besar tidak dapat diperbaiki. Pemberian ASI di dunia berkisar 50%. Cakupan ASI di Amerika Latin dan Karibia sebanyak 32% dan Negara berkembang 46%. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dan sikap ibu dengan pemberian ASI ekslusif pada bayi di Puskesmas Pinangsori Kabupaten Tapanuli Tengah Tahun 2022. Jenis penelitian yang digunakan adalah kuantitatif dengan pendekatan cross sectional study. Populasi penelitian adalah adalah semua ibu yang mempunyai bayi 6-12 bulan yang datang di Puskesmas Pinangsori Januari-Juli Tahun 2022 sebanyak 51 orang., dengan sampel 51 orang menggunakan metode total sampling. Analisa yang digunakan adalah uji Chi-square dengan hasil menunjukkan bahwa (p= 0,017), artinya ada hubungan sikap dengan pemberian ASI ekslusif pada bayi. Saran bagi ibu dapat menggali informasi mengenai pemberian ASI ekslusif pada bayi sebagai bekal pengetahuan. Kemudian ibu dapat memberikan ASI eksklusif kepada bayinya yaitu hanya memberikan ASI saja selama enam bulan penuh
FAKTOR – FAKTOR YANG MEMPENGARUHI KEJADIAN ANEMIA IBU HAMIL DI RUMAH BERSALIN CITRA
Authors: Anur Rohmin  , Siti Amallia  , Annisa Melinda  , Desti Ayu  
Published: February 2024

Anemia pada ibu hamil meningkatkan risiko terjadinya Bayi Berat Lahir Rendah (BBLR), kelahiran prematur, kematian ibu dan bayi. Hasil Riskesdas 2018 diketahui prevalensi anemia pada ibu hamil meningkat dari 37,1% pada tahun 2013 menjadi 48,9% pada tahun 2018. Tujuan penelitian ini ketahuinya faktor yang mempengaruhi kejadian anemia ibu hamil di Rumah Bersalin Citra. Metodelogi penelitian ini adalah survey analitik dengan pendekatan crossectional. Sampel penelitian adalah ibu hamil trimester I, II dan III yang berkunjung di Rumah Bersalin Citra berjumlah 94 orang diambil secara purposive sampling. Penelitian ini dilaksanakan pada tanggal 11 September – 13 November 2022. Hasil penelitian ini terdapat hubungan yang signifikan antara umur kehamilan (p-value:0,014), Paritas (p-value:0,046), Jarak Kehamilan (p-value:0,019), dan Kepatuhan minum Tablet Fe (p-value:0,009 ) dengan kejadian anemia pada ibu hamil. Variabel kepatuhan minum tablet Fe merupakan variabel yang paling dominan mempengaruhi kejadian anemia pada ibu hamil dengan OR. 2.9698: Kejadian anemia pada ibu hamil dipengaruhi oleh faktor umur kehamilan, paritas, jarak kehamilan dan kepatuhan minum tablet Fe dimana faktor kepatuhan minum tablet Fe merupakan faktor dominan mempengaruhi kejadian anemia ibu hamil. Diharapakan penelitian ini meningkatkan edukasi suplementasi tablet Fe pada wanita usia subur dan ibu hamil untuk mencegah terjadinya anemia pada kehamilan dan melakukan pemantauan kehamilan secara berkesinambungan.
Corporate Resilience and Competitiveness Relying on System Digitalization Through Ambidextrous Innovation
Authors: Sijabat Eduard Alfian Syamsya , Hidayati Hosianna Ayu 
Published: February 2024

The business process of shipping agencies in the post-pandemic is facing adjustments in providing services to customers. A digitalization system carried out by shipping agencies is a solution to respond to these changes and enable shipping agency businesses to survive. This study explored the extent of the impact of system digitalization on the resilience of shipping agency companies and also on the company's competitive advantage mediated by ambidextrous innovation. This study was conducted on 192 shipping agency companies that are members of shipping agency associations in Indonesia's main ports. Data collection was carried out by distributing questionnaires online then data processing was carried out and analysis was carried out, both descriptive statistical analysis and inferential statistics using WarPLS. The research results showed that the existence of a system digitalization program increases company resilience. Likewise, the existence of a system digitalization program also increases the company's competitive advantage. With a proactive response in the form of ambidextrous innovation from the company, digitalization is increasingly showing a significant influence on the company's resilience and also on the company's competitive advantage. The results of this research provide additional empirical contributions in proving the RBV-based theory of competitive advantage where with breakthrough innovation and adaptation to digitalization of the system which is part of the empowerment of company resources aimed at producing service products that are of unique value and cannot be imitated by competitors so that they have a competitive advantage for the company. The results of this research also provide a practical contribution to the shipping agency industry where it cannot be denied that the system digitalization process followed by ambidextrous innovation will increase the company's resilience and produce competitive advantage for the company as well.
Unveiling consumer perspectives on district heating: A Q methodology study
Authors: Radtke Uwe 
Published: February 2024

This study uses the Q methodology to investigate consumer perspectives on district heating, combining qualitative and quantitative methods across five research phases: foundation development, statement compilation (the Q-set), participant selection (the P-set), Q sorting and data analysis. The foundation was built using diverse sources yielding 39 statements. Experts from various disciplines were involved in the selection of statements using a two-round Delphi-like method to ensure objectivity. Subsequent steps included recruiting participants with varied perspectives, conducting Q sorting and analyzing data to reveal thought patterns. This research aims to shed light on consumer viewpoints regarding district heating, sustainability and general attitudes, assisting policymakers in promoting environmentally friendly energy practices. This research employs the Q methodology to collect and analyze subjective viewpoints concerning district heating, enhancing our understanding of consumer perspectives and their implications for sustainable energy systems. The results indicate a positive attitude towards district heating with strong support for further research and investment. Additionally, it aims to clarify the paper's results by highlighting the diverse consumer attitudes towards pricing mechanisms. The findings suggest transparent pricing mechanisms influenced by user behavior are more likely to gain acceptance. Four groups were found by using K-means clustering to analyse the data. These clusters showed preferences for longer, steady operating hours with low demand followed by shorter hours with low demand and resistance towards low operating hours with high demand. Future research could explore specific consumer profiles, private data or leverage waste heat from sources.
Il trattamento osteopatico nel paziente pediatrico cardiochirurgico: uno studio osservazionale retrospettivo
Authors: Trani Alessia , D'Antonio Alessandro , Zenobi Adriano , Cannarozzo Annalisa , Felici Valentina , Baldoni Monica , Mercuri Maurizio , Gatti Chiara 
Published: February 2024

BACKGROUND: L’osteopatia è una modalità di terapia manuale che, attraverso valutazioni dell’equilibrio neurovegetativo e trattamenti di tipo manipolativo, è in grado di individuare le rigidità presenti nel corpo e rimuoverle, in condizioni di salute e malattia.
OBIETTIVI: Valutare l’efficacia del trattamento manipolativo osteopatico, in base ai cambiamenti osservati nei parametri vitali, pianto e alimentazione, nel paziente pediatrico affetto da cardiopatia congenita, sottoposto a procedure cardiochirurgiche, aritmologiche ed emodinamiche.
METODI: È stato condotto uno studio osservazionale retrospettivo, in cui sono stati inclusi i pazienti sottoposti a procedure cardiochirurgiche, emodinamiche ed aritmologiche, con età compresa tra 0 e 18 anni. I dati sono stati raccolti attraverso la consultazione della documentazione clinica ed infermieristica, per un totale di 120 pazienti, suddivisi in due gruppi: gruppo non trattato (N= 67), sottoposto a nessun trattamento; gruppo trattato (N= 53), che ha ricevuto le cure osteopatiche. I dati sono stati elaborati tramite il programma Excel, i software SPSS versione 24.0 ed R© 3.6.3.
RISULTATI: L’analisi dei dati ha evidenziato una variazione assoluta Pre-Post trattamento in due dei parametri vitali considerati, quali la frequenza respiratoria (variazione assoluta di -4,43) e la frequenza cardiaca (variazione assoluta di -6,7), statisticamente significativa in entrambi i casi (p ≤0,002).
CONCLUSIONI: Lo studio descritto documenta come la co-terapia osteopatica è associata ad un cambiamento delle condizioni del bambino cardiochirurgico in termini di frequenza respiratoria e cardiaca. Considerando questi risultati, l’osteopatia sembrerebbe essere un supporto efficace della medicina convenzionale nella cura del bambino nel periodo post operatorio.
Biosensors Precision in Healthcare: A Scientific Odyssey
Authors: Hayat Khizar 
Published: February 2024

Biosensors have been the beacon of precision in the ever-evolving landscape of health care and offer a profound impact on diagnostics and patient care. These devices are designed to detect specific biological markers and convert then into measurable signals, seamlessly blending biology with cutting-edge technology. The diverse tapestry of biosensors encompass enzyme based sensors, immuno-assays, photo-biosensors, tissue-based sensors, DNA biosensors and nano-biosensors. Enzyme-based biosensors showcase unparalleled catalytic precision exemplified by glucose biosensors. Glucose oxidase serves as the biological catalyst and converts glucose into gluconic acid and hydrogen peroxide. Electrodes of the sensor then transduce this reaction into measurable signals which enables the precise quantification of glucose levels in diabetes management. Similarly, immunoassays rely on the specificity of antigen-antibody interactions. Most widely used immunoassay, Enzyme-linked immunosorbent assay (ELISA) exemplify this category, which finds applications in a number of diagnostics and provide a window into immunological responses and diseases such as HIV. Advancing the field of biosensing are the photobiosensors which utilize diverse technologies such as fluorescence resonance energy transfer (FRET) to illuminate biological processes. Genetically encoded biosensors that employ proteins like green fluorescent protein (GFP), enable non-invasive monitoring of cellular dynamics and offer real-time insights. Another cateogory, tissue-based biosensors converge the technology with the physiological environments. For instance, implantable glucose sensors that continuously monitor blood glucose concentrations and provide real-time data for personalized treatment approaches. At the core of precision diagnostics lie DNA biosensors such as DNA microarrays. They offer parallel analysis of gen expression, influencing decisions in cancer diagnostics and pharmacogenomics. Nanobiosensors, represented by nanoparticle-based sensors, navigate the nano-frontiers with exceptional sensitivity. For example, quantum dots exhibit unique optical properties for sensitive detection. Likewise, gold nanoparticles based biosensors enable real-time monitoring of drug release in drug delivery systems and emphasize their role in precision medicine. As biosensors advance, ethical considerations come to the forefront. Issues such as data privacy, consent, and equitable access to these technologies demand careful attention. It becomes imperative to ensure that biosensors are developed and deployed responsibly with a keen awareness of potential societal implications in navigating the ethical landscape. In the symphony of precision that biosensors bring to healthcare, their types and applications reflect not only technological prowess but also the ethical responsibility inherent in their development and deployment. As these devices continue to evolve, the healthcare landscape stands on the brink of a new era, where precision and ethics intertwine for the betterment of patient outcomes.
Associations Between Child Maltreatment Types and Pre- and Post-Partum Posttraumatic Stress Disorder Symptoms: A Brief Report
Authors: Frederickson Alesha , Pigeon Sereena , Hébert Martine , Bernier Annie , Frappier Jean-Yves , Langevin Rachel 
Published: February 2024

Objective: To foster resilience through reducing posttraumatic stress disorder (PTSD) symptoms in pregnant mothers with child maltreatment (CM) histories, it is important to understand factors impacting their well-being. This study explored whether CM predicted the severity of PTSD symptoms and symptom clusters during pregnancy and change in symptoms from pregnancy (Time 1; T1) to 3 months postpartum (Time 2; T2).
Methods: 88 pregnant women (aged 18 to 29) completed surveys on CM exposure, adult interpersonal trauma experiences, and PTSD symptoms at T1; 58 participated at T2.
Results: Stepwise regressions were conducted with the covariates age, family status, and adult interpersonal traumas. When accounting for all CM types, only neglect remained associated with overall PTSD symptoms (Ft1(1, 71) = 28.93, p < .001) and for each of the PTSD symptom clusters (ps < .01). Physical abuse remained associated with the alterations in cognition and mood cluster. No CM types were associated with changes in PTSD symptoms from T1 to T2.
Implications: In future research, the implications of neglect for pregnant mothers should be explored in depth. Perinatal care should be trauma-informed, including assessing for CM histories, to foster greater resilience by reducing perinatal PTSD symptoms.
BOWEL OBSTRUCTION FROM COMPLETE TRANSMURAL MIGRATION OF A GOSSYPIBOMA INTO THE ILEUM; A RARE OCCURRENCE
Authors: Agada Horace , MALGWA ISHAKU YAKUBU , Iliya Joel 
Published: February 2024

Gossypibomas are infrequent abdominal pathology associated with increased morbidity and mortality. They are foreign bodies of predominantly cotton material that are erroneously left in body cavities following surgery. They represent an extremely rare but avoidable cause of bowel obstruction and should be considered as a differential diagnosis in patients presenting with Bowel obstruction following previous abdominal surgery.
We present the case of a young woman with clinical features in keeping with mechanical bowel obstruction from suspected post-operated adhesion. However, intra-operative finding revealed a complete transmural migration of a Gossypiboma into the terminal ileum. She had segmental ileal resection, extraction of the gossypiboma and primary end-to-end ileo-ileal anastomosis. Her recovery period was uneventful.
Keywords; Anastomosis, Bowel obstruction, Gossypiboma, laparotomy
PATTERN OF MANDIBULAR FRACTURES IN A NIGERIAN TERTIARY HEALTH INSTITUTION; A 4-YEAR RETROSPECTIVE STUDY
Authors: Adeyemi Moshood , Ernest Moninuola Adebusola , Sanni-Abdullahi Shakira , Igben Ehigie , Garba Ashiru , Nnebedum Mirian 
Published: February 2024

Background: According to surveys, mandibular injuries aetiology varies between countries and even between centers in the same country. Mandibular fractures are the second most frequent facial injury, accounting for 15.5% to 59% of all facial fractures globally. The study aimed to find out if there were predictable patterns of fractured in the north central part of Nigeria.
Materials and Methods: Mandibular fracture patients treated during a 4-year period were identified in a retrospective analysis and examined based on factors including age, sex, mode of trauma, month and day of the week of presentation, number and anatomic location, treatment method and sequelae.
Results: The study reviewed 75 participants between the ages of 2 and 70. The mean age was 30.69 ± 11.22 years, and the gender split was 70 males (93.20%) and 5 females (6.80%), with a p-value of 0.09. The main cause was motorbike accident (68%) and head on collision was the major mechanism of trauma road traffic accidents (RTAs, 68.8%) and none of motorbike riders nor did passengers wear crash helmet. A total of ninety-nine fractures out of one hundred and six fractures were observed in males. A small percentage of patients (33%) exhibited altered consciousness, however there was no statistically significant link between the aetiology and level of consciousness (p=0.818).
Conclusion: The mandibular body was most severely impacted and the primary mechanism of injury was head-on collision between two motorbikes. Speed restrictions and legislative law should be placed on the use of crash helmet.