bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eribulin is an immune potentiator in breast cancer that upregulates human leukocyte antigen class I expression via the induction of NOD‐like receptor family CARD domain‐containing 5
Authors: Wada Asaka , Hirohashi Yoshihiko , Kutomi Goro , Murata Kenji , Iwabuchi Sadahiro , Mizue Yuka , Murai Aiko , Kyuno Daisuke , Shima Hiroaki , Minowa Tomoyuki , Sasaki Kenta , Kubo Terufumi , Kanaseki Takayuki , Tsukahara Tomohide , Nakatsugawa Munehide , Hashimoto Shinichi , Osanai Makoto , Torigoe Toshihiko , Takemasa Ichiro 
Published: November 2023

AbstractEribulin inhibits microtubule polymerization and improves the overall survival of patients with recurrent metastatic breast cancer. A subgroup analysis revealed a low neutrophil to lymphocyte ratio (NLR) (<3) to be a prognostic factor of eribulin treatment. We thus hypothesized that eribulin might be related to the immune response for breast cancer cells and we analyzed the effects of eribulin on the immune system. Immunohistochemical staining revealed that human leukocyte antigen (HLA) class I expression was increased in clinical samples after eribulin treatment. In vitro assays revealed that eribulin treatment increased HLA class I expression in breast cancer line cells. RNA‐sequencing demonstrated that eribulin treatment increased the expression of the NOD‐like family CARD domain‐containing 5 (NLRC5), a master regulator of HLA class I expression. Eribulin treatment increased the NY‐ESO‐1‐specific T‐cell receptor (TCR) transduced T (TCR‐T) cell response for New York oesophageal squamous cell carcinoma 1 (NY‐ESO‐1) overexpressed breast cancer cells. The eribulin and TCR‐T combined therapy model revealed that eribulin and immunotherapy using TCR‐T cells has a synergistic effect. In summary, eribulin increases the expression of HLA class 1 via HLA class 1 transactivatior NLRC5 and eribulin combination with immunotherapy can be effective for the treatment of breast cancer.
Measuring ecosystem services and ecological sensitivity for comprehensive conservation in Giant Panda National Park
Authors: Li Cheng , Hou Rong , Bao Ziqiang , Wu Wei , Owens Jacob R. , Bi Wenlei , Xu Qiang , Gu XiaoDong , Xiang Zuofu , Qi Dunwu 
Published: November 2023

AbstractChina announced the development of its first 5 national parks in 2021, the primary objective of which is to conserve the natural state and integrity of natural ecosystems. As such, ecosystem services and biodiversity levels are crucial assessment factors for the parks. For Giant Panda National Park (GPNP), we evaluated ecological sensitivity based on water and soil erosion and rocky desertification; ecosystem services based on headwater conservation, soil and water conservation, and biodiversity conservation; and presence of giant panda (Ailuropoda melanoleuca) and sympatric species (e.g., takin [Budorcas taxicolor], Asiatic black bear [Ursus thibetanus]) habitat suitability derived from niche modeling to identify the ecosystem status and assess ecological problems within the park. From our results, we proposed ecologically critical areas to target to meet the park's goals. The suitable habitat for pandas and sympatric species encompassed 62.98% of the park and occurred mainly in the Minshan Mountains. One quarter of the total area (25.67%) contained areas important for ecosystem services. Ecologically sensitive and extremely sensitive areas covered 88.78% of the park and were distributed mainly in Qionglaishan and Minshan Mountains. This coverage indicated that there was much habitat for pandas and sympatric species but that the ecosystems in GPNP are vulnerable. Therefore, ecologically critical areas encompassed all suitable habitats for all the species examined and areas important and extremely important to ecosystem service provision,ecologically sensitive and extremely sensitive areas, encompassed 15.17% of panda habitat, accounted for 16.37% of the GPNP area, and were distributed mainly in the Minshan Mountains. Our results indicated where conservation efforts should be focused in the park and that by identifying ecologically critical areas managers can provide targeted protection for wildlife habitat and ecosystems and effectively and efficiently protect the composite ecosystem. Additionally, our methods can be used to inform development of new national parks.
CDK5R1,GSE1,HSPG2andWDFY3as indirect epigenetic‐sensitive genes in atrial fibrillation
Authors: Infante Teresa , Pepin Mark E. , Ruocco Antonio , Trama Ugo , Mauro Ciro , Napoli Claudio 
Published: November 2023

AbstractBackgroundAlthough mounting evidence supports that aberrant DNA methylation occurs in the hearts of patients with atrial fibrillation (AF), noninvasive epigenetic characterization of AF has not yet been defined.MethodsWe investigated DNA methylome changes in peripheral blood CD4+T cells isolated from 10 patients with AF relative to 11 healthy subjects (HS) who were enrolled in the DIANA clinical trial (NCT04371809) via reduced‐representation bisulfite sequencing (RRBS).ResultsAn atrial‐specific PPI network revealed 18 hub differentially methylated genes (DMGs), wherein ROC curve analysis revealed reasonable diagnostic performance of DNA methylation levels found withinCDK5R1(AUC = 0.76;p = 0.049),HSPG2(AUC = 0.77;p = 0.038),WDFY3(AUC = 0.78;p = 0.029),USP49(AUC = 0.76;p = 0.049),GSE1(AUC = 0.76;p = 0.049),AIFM1(AUC = 0.76;p = 0.041),CDK5RAP2(AUC = 0.81;p = 0.017),COL4A1(AUC = 0.86;p < 0.001),SEPT8(AUC = 0.90;p < 0.001),PFDN1(AUC = 0.90;p < 0.01) andACOT7(AUC = 0.78;p = 0.032). Transcriptional profiling of the hub DMGs provided a significant overexpression ofPSDM6(p = 0.004),TFRC(p = 0.01),CDK5R1(p < 0.001),HSPG2(p = 0.01),WDFY3(p < 0.001),USP49(p = 0.004) andGSE1(p = 0.021) in AF patients vs HS.ConclusionsCDK5R1,GSE1,HSPG2andWDFY3resulted the best discriminatory genes both at methylation and gene expression level. Our results provide several candidate diagnostic biomarkers with the potential to advance precision medicine in AF.
The age‐wage‐productivity puzzle: Evidence from the careers of top earners
Authors: Scarfe Rachel , Singleton Carl , Sunmoni Adesola , Telemo Paul 
Published: November 2023

AbstractThere is an inverted u‐shaped relationship between age and wages in most labor markets, but the effects of age on productivity are often unclear. We use panel data in a market of high earners, professional footballers (soccer players) in North America, to estimate age‐productivity and age‐wage profiles. We find stark differences; wages increase for several years after productivity has peaked, before dropping sharply at the end of a career. This poses the question: why are middle‐aged workers seemingly overpaid? We investigate a range of possible mechanisms that could be responsible, only finding evidence that tentatively supports a talent discovery theory.
Does ESG reputational risk affect the efficiency and speed of adjustment of corporate investment?
Authors: Chasiotis Ioannis , Gounopoulos Dimitrios , Konstantios Dimitrios , Naoum Vasilios‐Christos , Patsika Victoria 
Published: November 2023

AbstractThis study explores the relationship between environmental, social, and governance (ESG) reputational risk and investment efficiency. We provide evidence that ESG reputational risk relates to higher corporate suboptimal investment (underinvestment) and a lower speed of adjustment back to the optimal investment level. Our findings hold for parametric and nonparametric estimations of underinvestment and are robust to several techniques that address endogeneity and self‐selection. Overall, our study highlights the important role of ESG reputational risk in determining corporate investment efficiency.
Universities in a contested space: The dominance of calculative accounting practices and the development of a research agenda
Authors: Hyndman Noel , Lapsley Irvine , Liguori Mariannunziata 
Published: November 2023

AbstractOver the last few decades, neoliberal, managerial, reforms have dominated the university sector in a number of different countries. Calculative practices, including performance measures and indicators, have spread and targets, in terms of research outputs and increasing student numbers in order to generate “profit”, have become the norm, despite the many voices seeing this as often clashing with the mission of universities to create knowledge and contribute to social development. The paper provides an overview of the changing focus on how universities have been managed over time and, at the same time, of the emergence and measurementof Public Value themes in the university sector. A future research agenda is proposed for those interested in the study of the university sector, together with possibleresearch questions to further this area.
Research of Maillard reaction and stability of liquid infant formulas during storage
Authors: Liao Minhe , Yang Wei , Jin Ritian , Shang Jiaqi , Li Meng , Kang Jiaxin , Wei Zikai , Teng Xiangyu , Xin Qiuyan , Liu Ning , Ren Haowei 
Published: November 2023

SummaryThis study investigated the Maillard reaction (MR) and the stability of liquid infant formulas (LIFs) stored at 5 °C, 25 °C and 40 °C for 6 months. With the increase in storage temperature, the concentrations of 2‐furoylmethyl‐ε‐lysine (furosine) increased from 60.72 to 109.60 mg/100 g protein and Nɛ‐ Carboxy methyl lysine (CML) increased 106.82 to 197.04 mg/100 g protein. Colour became darker, yellower and redder, and pH values decreased. Negative charges increased during the first 3 months and decreased during the last 3 months. Fat globule sizes increased and particle size distribution (PSD) regressed, and the accumulation of fat was clearly observed by confocal laser scanning microscopy (CLSM). Shear thickened with the increase in shear rate, and the turbiscan stability index (TSI) values increased. In summary, these results indicated that lower storage temperature (5 °C) inhibits the MR and reduces unstable changes of LIF during storage period; thus, the nutritional value of LIF can be largely preserved.
Disparité des trajectoires professionnelles des diplômés australiens en fonction de leur origine sociale: étude longitudinale à partir de données administratives couplées couvrant l'ensemble de la population
Authors: ZAJĄC Tomasz , TOMASZEWSKI Wojtek , PERALES Francisco , XIANG Ning 
Published: November 2023

RésuméS'il est de plus en plus établi que les études supérieures améliorent les perspectives professionnelles, l'inégalité de leur rendement suscite des inquiétudes croissantes. Les auteurs utilisent un nouveau jeu de données administratives couplées couvrant l'ensemble des étudiants diplômés d'une université australienne entre 2005 et 2011 pour comparer, sur dix ans, la trajectoire professionnelle de publics défavorisés à l'aune de différents critères (position socio‐économique, origine ethnique, lieu de résidence, migration, incapacité) à celle de leurs homologues favorisés. Ils constatent une grande hétérogénéité des trajectoires en termes de revenu et de perception de prestations sociales. Ces résultats ont d'importantes implications pour les politiques visant à améliorer l'équité sociale sur le marché du travail.
Trayectorias laborales divergentes de los graduados australianos socialmente favorecidos y desfavorecidos. Análisis longitudinal
Authors: ZAJĄC Tomasz , TOMASZEWSKI Wojtek , PERALES Francisco , XIANG Ning 
Published: November 2023

ResumenPese a la evidencia de que la educación universitaria mejora las perspectivas laborales, preocupan sus desiguales rendimientos. Sobre los datos administrativos de toda la población de graduados en universidades australianas en el periodo 2005‐2011, se estudian las trayectorias laborales de los individuos procedentes de entornos sociales desfavorecidos (por estatus socioeconómico, migración, discapacidad, origen étnico y zona de residencia) en comparación con los más favorecidos, a lo largo de diez años. La heterogeneidad de la evolución de los ingresos laborales y la percepción de prestaciones por desempleo entre los graduados de distintos grupos es notable. Esto tiene hondas implicaciones para las políticas de equidad social.
Is video games' effect on attitudes universal? Results from an empirical study comparing video games' impact on the attitude change of players with different backgrounds
Authors: Kolek Lukáš , Martinková Patrícia , Vařejková Michaela , Šisler Vít , Brom Cyril 
Published: November 2023

AbstractBackgroundExisting studies confirm that some video games can change players' attitudes. However, since we do not know the specific elements responsible for attitude change, the potential of video games to achieve desired educational or behavioural outcomes often remains unfulfilled.ObjectivesTo fill the research gap, our study examined whether the perspective‐taking game mechanic in the serious game Czechoslovakia 38–89: Borderlands, which had previously been shown to affect attitudes, would have the same effect on another sample of players with different characteristics.MethodsWe have assessed the effect of a historical video game using a perspective‐taking mechanic on players' explicit and implicit attitudes. Explicit attitude changes were measured at a general level, meaning a broad evaluation of a depicted historical event, and at a specific level, meaning a more detailed evaluation of specific aspects of the event. Simultaneously, we measured the effect of players' perceived attitude importance on attitude change. The study used a sample of 137 young adults.Results and ConclusionsThis study's results indicate a significant pretest‐posttest explicit attitude change on the general level and on a specific level in comparison to the control group. Perspective‐taking game mechanics is particularly important for explicit attitude change. No change was found in implicit attitudes. The effect of the perceived attitude importance on attitude change was not confirmed.TakeawaysAs one of the first to focus on the effects of specific game mechanics on attitudes, this study confirmed that perspective‐taking has stable, short‐term effects on attitude change even across different research samples.
CNS lymphoma masquerading as stroke: Cases report and literature review
Authors: Liang Xiping , Wang Chaoyu , Liu Yao 
Published: November 2023

AbstractCentral nervous system (CNS) involvement in Hodgkins lymphoma (HL) is extremely rare. There are only two reported case series of intracranial involvement of HL. CNS HL can be presented at any point in the course of HL, most mimicking with a prominent neurological symptom. This challenges the diagnosis of CNS involvement and stroke. Here, we report four cases of patients having refractory HL with CNS involvement to garner attention among neurologists for this rare disease presents with stroke symptoms and reviews its disease characteristics, prognosis, and treatment.
Construction of key quality indicators for aged care facilities in China: A two‐tier Delphi study
Authors: Yan Lichun , Pu Haixu , Shi Xiaoyin , Yu Qian , Wang Zhiyi , Hu Yajing , Zhang Yinhua , Zhang Xiaoqin 
Published: November 2023

AbstractAimTo construct key quality indicators for aged care facilities in China.BackgroundEvaluating the care quality in aged care facilities is problematic. Evaluation of nursing care quality is important for improving nursing and self‐supervision in aged care facilities. However, a few regulations and studies regarding care quality evaluation have been implemented in China.Design and MethodThis two‐tier Delphi study aimed to achieve consensus on key quality indicators for aged care facilities in China. The entry pool was determined by literature review and research team discussion, followed by a discussion by a panel of experts to establish the items of the Delphi study. Finally, key care quality indicators were established through a two‐round Delphi study. This study followed the SQUIRE 2.0 guidelines.ResultsThe initial 16 quality indicators of the entry pool was developed based on a literature review and a group discussion. Sixteen quality indicators were reduced to eight after the expert discussion. After two rounds of expert consultation, the eight quality indicators became nine, which were then evaluated for importance, formula rationality, and operability using Kendall's harmony coefficients (first round: 0.150, 0.143 and 0.169, respectively; second round: 0.209, 0.159 and 0.173, respectively).ConclusionsKey quality indicators provide quantifiable evidence for evaluating the care quality in aged care facilities, but their applicability needs continuous improvement.Relevance to Clinical PracticeNine key quality indicators were selected from numerous indicators for measuring the care quality in aged care facilities, supporting the evaluation of the care quality and self‐supervision for aged care facilities.Elderly or Public ContributionNo elderly or public contribution.
Shipwrecks act as de facto Marine Protected Areas in areas of heavy fishing pressure
Authors: Hickman Jenny , Richards Joe , Rees Adam , Sheehan Emma V. 
Published: November 2023

AbstractUbiquitous, industrial use of bottom‐towed fishing gear since the 1800s has altered marine communities and ecosystem services. Outside of legal protection, only areas inaccessible to trawlers are offered any protection. Shipwrecks present hazards to fishing gear and are rarely subject to trawling pressure. As many have been in situ for >100 years, they offer a baseline of ecological potential when trawling pressure is reduced or removed. Five shipwrecks were surveyed off the Berwickshire coast, some within the Static Gear Reserve and others outside. Video transects were collected of shipwrecks, the surrounding 50 m radius and control locations >150 m from the wreck site. Species identified were assigned a category based on their vulnerability to trawling. The effect of distance from a shipwreck on ecological communities within sites Open and Closed to trawling was investigated. The ecological importance of shipwrecks increased relative to trawling pressure. In Open sites, abundance was 340% greater on Wreck locations than Control. Conversely, within Closed sites, abundance was 149% greater in Control locations than Wreck. In Open sites, shipwreck communities are more similar to those in Closed sites, than to the habitat surrounding the shipwreck. Vulnerable species, mostly large, sessile filter feeders, are almost entirely absent from Open sites, but account for ~28% of the total abundance on shipwrecks in Closed sites. This study offers a quantifiable method to evaluate the ecological contribution of shipwrecks in disturbed areas and suggests their role may warrant further research, and consideration in conservation policy, such as inclusion in 30 × 30 objectives. Our findings also demonstrate the possible ecological gains of expanding or including static gear reserves across Marine Protected Areas.
Unravelling underlying processes in intraprofessional workplace learning in residency
Authors: Teheux Lara , Kuijer‐Siebelink Wietske , Bus Lotte L. , Draaisma Jos M. T. , Coolen Ester H. A. J. , van der Velden Janiëlle A. E. M. 
Published: November 2023

AbstractBackgroundTo deliver high‐quality collaborative care, residents need to be trained across the boundaries of their medical specialty (intraprofessional learning). The current literature does not provide insights into the underlying processes that influence intraprofessional learning. The aim of this study was to gain insight into the processes that occur during intraprofessional workplace learning in residency training, by exploring everyday intraprofessional interactions experienced by residents, with the ultimate objective of improving collaborative practice.MethodWe conducted a focused ethnography using field observations and in‐depth interviews with residents at an academic children's hospital in the Netherlands. In 2022, nine residents from four different medical specialties were shadowed and/or interviewed. In total, >120 hours of observation and 10 interviews were conducted. Data collection and analysis were conducted iteratively and discussed in a research team with diverse perspectives, as well as with a sounding board group of stakeholders.ResultsResidents were involved in numerous intraprofessional interactions as part of their daily work. We identified three themes that shed light on the underlying processes that occur during intraprofessional workplace learning: (1) residents' agency, (2) ingroups and outgroups and (3) communication about intraprofessional collaboration.ConclusionsCollaborative practice offers many intraprofessional learning opportunities but does not automatically result in learning from, with and about other specialties to improve intraprofessional collaborative care. Overarching the identified themes, we emphasise the pivotal role of the resident–supervisor dyad in facilitating residents' engagement in the learning opportunities of complex intraprofessional care. Furthermore, we propose that promoting deliberate practice and shared responsibility in collaborative care are crucial to better prepare residents for their roles and responsibilities in delivering high‐quality collaborative patient care.
The UAE's Foreign Policy Drivers
Authors: Kirmanj Sherko , Tofik Ranj 
Published: November 2023

AbstractA small state with big ambitions, the United Arab Emirates has become a major player in the Middle East region, especially since the Arab Spring. It played a major role in weakening the Muslim Brotherhood by supporting rulers like Abdel Fattah al‐Sisi of Egypt and would‐be leaders such as General Khalifa Haftar of Libya. Abu Dhabi was the critical player behind the blockade of Qatar in 2017, and it has taken a leading role in the normalization of Syrian President Bashar al‐Assad. This article employs a range of theoretical perspectives, including structural realism and liberalism, to explain the UAE's foreign policy and behavior. It argues that there are at least four major drivers: combating political Islam, containing Iran, dominating regional ports and waterways, and increasing economic prosperity.
Advances in understanding grapevine downy mildew: From pathogen infection to disease management
Authors: Peng Junbo , Wang Xuncheng , Wang Hui , Li Xinghong , Zhang Qi , Wang Meng , Yan Jiye 
Published: November 2023

AbstractPlasmopara viticola is geographically widespread in grapevine‐growing regions. Grapevine downy mildew disease, caused by this biotrophic pathogen, leads to considerable yield losses in viticulture annually. Because of the great significance of grapevine production and wine quality, research on this disease has been widely performed since its emergence in the 19th century. Here, we review and discuss recent understanding of this pathogen from multiple aspects, including its infection cycle, disease symptoms, genome decoding, effector biology, and management and control strategies. We highlight the identification and characterization of effector proteins with their biological roles in host–pathogen interaction, with a focus on sustainable control methods against P. viticola, especially the use of biocontrol agents and environmentally friendly compounds.
Cultural and linguistic nationalism in the Esperanto movement: The Catalan case (1887–1928)
Authors: Requejo De Lamo Pilar 
Published: November 2023

AbstractThe emergence of Esperantism in 1887 coincided with a nationalist movement in Catalonia that was gaining momentum. During the first decades of the 20th century, both phenomena became deeply intertwined, as Catalan nationalists embraced the constructed language and used the transnational network that developed around it to revindicate their cultural particularities. This article explores how the relationship between the constructed language and Catalanists evolved between 1887 and 1928, when a political regime unfavourable to regional nationalisms forced the Catalan Esperanto movement to reframe their activities and adopt a more apolitical and neutral position.