bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kronotipler Depresyon Riskini Etkiler mi?
Authors: YURT TÜRER Büşra , YILDIRIM İlknur Gökçe 
Published: November 2023

Sirkadiyen işlevsellik açısından bireylerin tercih ettiği davranışlarda ve uyku zamanlamasında farklılıklar gözlenmektedir. Bu farklılıklara göre insanlar “sabah” “akşam” “ara tip” gibi çeşitli koronotiplere göre kategorize edilmektedir. Akşam kronotipli bireylerin gün içinde daha fazla enerji aldıkları, daha düşük diyet kalitesine sahip oldukları ve sağlıksız beslenme davranışları sergilemeye daha yatkın oldukları gösterilmiştir.
Krono-beslenme günümüzde beslenme döngüsünün organizma üzerindeki etkilerini araştıran bir alan olarak daha çok ilgi görmektedir. Bu yaklaşıma göre diyetin içeriğinin yanında aydınlık-karanlık döngü içerisinde beslenme zamanlanmasının metabolik ve psikolojik sağlık için önemi vurgulanmaktadır. Yapılan çalışmalarda sirkadiyen ritimdeki bozulmaların kardiyovasküler bozukluklar, diyabet, endokrin-metabolik bozukluklar ve uyku bozukluklarını etkilemesinin yanında depresyon gibi psikiyatrik bozukluklara da nasıl yol açabileceğine dair çeşitli mekanizmalar öne sürülmektedir. Bu derlemede, kronotiplere göre depresyon gelişme riski ve krono-beslenme ile depresyon ilişkisinin literatür ışığında açıklanması amaçlanmaktadır.
Andean giants: Priscula spiders from Ecuador, with notes on species groups and egg-sac troglomorphism (Araneae: Pholcidae)
Authors: Huber Bernhard A. , Meng Guanliang , Dupérré Nadine , Astrin Jonas , Herrera Mauricio 
Published: November 2023

The Andean genus Priscula Simon, 1893 includes the largest Neotropical pholcid spiders, but due to their mostly cryptic lifestyle they remain poorly collected and poorly studied. Many species available in collections remain undescribed and nothing has been published about the phylogeny and the biology of the genus. Here, we deal with a recent collection of Priscula spiders from Ecuador, the country of origin of the type species, P. gularis Simon, 1893. We describe eight new species, collected at 17 localities at altitudes from 640–3160 m, all based on males and females: P. azuay sp. nov., P. llaviucu sp. nov., P. espejoi sp. nov., P. esmeraldas sp. nov., P. chapintza sp. nov., P. pastaza sp. nov., P. bonita sp. nov., and P. lumbaqui sp. nov. We use a sample of approximately 26 species-level taxa, mostly from Ecuador and Venezuela, to propose a first hypothesis about relationships within the genus. Our data (mainly CO1) suggest the existence of five species groups, three of which are represented in Ecuador. The cave-dwelling P. pastaza sp. nov. is only slightly troglomorphic (paler than usual; anterior median eyes strongly reduced or lost) but differs dramatically from forest-dwelling congeners in its biology: it hangs fully exposed in its web during the day; it produces egg sacs with only 6–7 eggs (average in 15 other species: 42 eggs); and it produces the largest eggs relative to body size of all studied species.
Real-World Evidence of Intra-institutional Performance Variation in Indefinite Diagnosis of Pleural Effusion Cytology
Authors: Chen Kuang-Hua , Kuo Chien-Yi , Chen Tai-Di 
Published: November 2023

Context.—
Pleural effusion cytology has been widely used in the investigation of pathologic fluid accumulation in pleural spaces. However, up to one-tenth of the cases were not given a definitive diagnosis. These cases have largely been neglected in the bulk of the literature.

Objective.—
To provide real-world data on indefinite diagnoses including “atypia of uncertain significance” (AUS) and “suspicious for malignancy” (SFM) in pleural effusion cytology and to investigate pathologists’ practice patterns on using these diagnostic categories.

Design.—
We reported the diagnoses of 51 675 cases. Descriptive statistics and correlation coefficients were used to analyze the relationships between different diagnostic categories and pathologists’ practice patterns and possible explanatory variables.

Results.—
The diagnoses AUS and SFM were reported in 4060 cases (7.86%) and 1554 cases (3.01%) in the cohort, respectively. The mean rates for these indefinite diagnoses varied up to 3-fold between pathologists. Correlations were found between AUS and SFM, as well as between indefinite diagnoses and negative for malignancy (NFM). No correlations were found between pathologists’ years of experience or case volume and the rates of indefinite diagnosis or diagnostic certainty.

Conclusions.—
A real-world baseline for the rates of indefinite diagnoses in pleural effusion cytology is provided in this large retrospective study. Pathologists show significant variation in their use of indefinite diagnostic categories, and the tendency to use these ambiguous terms was not correlated with individuals’ experience or case volume. How to untangle the intertwined relationship between the uncertainty of indefinite diagnoses and that of NFM requires future prospective studies.
Novel Dosing and Monitoring of Aspirin in Infants With Systemic-to–Pulmonary Artery Shunt Physiology: the SOPRANO Study
Authors: Branstetter Joshua W. , Woods Gary , Zaki Hania , Coolidge Nicole , Zinyandu Tawanda , Shashidharan Subhadra , Aljiffry Alaa 
Published: November 2023

OBJECTIVES
Provision of pulmonary blood flow with a systemic-to–pulmonary artery shunt is essential in some patients with cyanotic congenital heart disease. Traditionally, aspirin (ASA) has been used to prevent thrombosis. We evaluated ASA dosing with 2 separate antiplatelet monitoring tests for accuracy and reliability.

METHODS
This is a retrospective, pre-post intervention single center study. Two cohorts were evaluated; the pre-intervention group used thromboelastography platelet mapping (TPM) and post-intervention used VerifyNow aspirin reactivity unit (ARU) monitoring. The primary endpoint was to compare therapeutic effect of TPM and ARU with regard to platelet inhibition. Inadequate platelet inhibition was defined as TPM &lt;50% inhibition and ARU &gt;550.

RESULTS
Data from 49 patients were analyzed: 25 in the TPM group and 24 in the ARU group. Baseline characteristics were similar amongst the cohorts. The TPM group had significantly more patients with inadequate platelet inhibition (14 [56%] vs 2 [8%]; p = 0.0006) and required escalation with additional thromboprophylaxis (15 [60%] vs 5 [21%]). There was no difference in shunt thrombosis (1 [2%] vs 0 [0%]; p = 0.32), cyanosis requiring early re-intervention (9 [36%] vs 14 [58%]; p = 0.11), or bleeding (15 [60%] vs 14 [58%]; p = 0.66).

CONCLUSION
With similar cohorts and the same ASA-dosing nomogram, ARU monitoring resulted in a reduced need for escalation of care and concomitant thromboprophylaxis with no difference in adverse outcomes. Our study suggests ARU monitoring compared with TPM may be a more reliable therapeutic platelet inhibition test for determining ASA sensitivity in children with congenital heart disease requiring systemic-to–pulmonary artery shunt.
Melatonin Use in Infants Admitted to Intensive Care Units
Authors: Bradford Caitlyn , Miller Jamie L. , Harkin Maura , Chaaban Hala , Neely Stephen B. , Johnson Peter N. 
Published: November 2023

OBJECTIVES
Sleep deprivation is a risk factor for delirium development, which is a frequent complication of intensive care unit admission. Melatonin has been used for both delirium prevention and treatment. Melatonin safety, efficacy, and dosing information in neonates and infants is lacking. The purpose of this study was to describe melatonin use in infants regarding indication, dosing, efficacy, and safety.

METHODS
This descriptive, retrospective study included infants &lt;12 months of age admitted to an intensive care unit receiving melatonin. Data collection included demographics, melatonin regimen, sedative and analgesic agents, antipsychotics, and delirium-causing medications. The primary objective was to identify the melatonin indication and median dose. The secondary objectives included change in delirium, pain, and sedation scores; change in dosing of analgesic and sedative agents; and adverse event identification. Wilcoxon signed rank tests and linear mixed models were employed with significance defined at p &lt; 0.05.

RESULTS
Fifty-five patients were included, with a median age of 5.5 months (IQR, 3.9–8.2). Most (n = 29; 52.7%) received melatonin for sleep promotion. The median body weight–based dose was 0.31 mg/kg/dose (IQR, 0.20–0.45). There was a statistical reduction in cumulative morphine equivalent dosing 72 hours after melatonin administration versus before, 17.1 versus 21.4 mg/kg (p = 0.049). No adverse events were noted.

CONCLUSIONS
Most patients (n = 29; 52.7%) received melatonin for sleep promotion at a median dose was 0.31 mg/kg/dose. Initiation of melatonin was associated with a reduction of opioid exposure; however, there was no reduction in pain/sedation scores.
The efficacy of clinacanthus nutans (burm.f.) lindau against cyprinid herpesvirus 3 in koi fin cell line and fancy carp (cyprinus carpio koi)
Authors:   , Haetrakul Thanida 
Published: November 2023

Cyprinid herpesvirus 3 (CyHV-3) or Koi herpesvirus (KHV) is a virulence viral infection in common carp and koi. The disease has caused global epizootic and economic loss in fish aquaculture and in the wild. Clinacanthus nutans (Burm. f.) Lindau is a well-known medicinal plant used in Thai traditional medicine. Virucidal effects of the plant extract against human herpes simplex virus have been reported. In this study, C. nutans crude extract, dichloromethane fraction and n-butanol fraction were tested for antiviral activities against CyHV-3 in koi fin cell line. The 50% cytotoxic concentration of crude extract was at 1,701.57 µg/ml, dichloromethane fraction at 522.47 µg/ml and n-butanol fraction at 1,797.98 µg/ml. Effective concentrations of the crude extract pre and post-infection were at 250, 500 and 1,000 µg/ml. The dichloromethane fraction and n-butanol fraction did not have antiviral activity. The C. nutans crude extract was chosen to perform antiviral activity test in koi carp. The results showed effective antiviral activity against CyHV-3 pre and post infection. The 50% lethal concentration of extract was higher than 5,000 µg/ml. The 50% effective doses (ED50) were 991.59 µg/ml, 782.72 µg/ml, 749.05 µg/ml and 707.80 µg/ml at 1, 2, 3 and 4 hours pre-infection, respectively. The ED50 from post infection test were 2,050.88 µg/ml and 2,337.74 µg/ml at 0 and 24 hours, respectively. The results showed that crude extract expressed antiviral activity against CyHV-3 can be applied as therapeutic agent in common carp and koi aquacultures.
Technology in Distance Learning
Authors: Bochorishvili Nino , Lomsadze Nino , Bochorishvili Irakli 
Published: November 2023

Since there are no scheduled classes to attend and all necessary information is available online, distance education has replaced synchronous learning for many students and teachers during the pandemic. However, we are still unsure of the long-term effects of distance learning and whether it provides the same value as learning in a classroom face-to-face.
This article discusses important challenges that colleges must take into account, such as how to help students without dependable internet access or technology participate in digital learning, as well as some specific issues related to the management of remote learning.
Lymphoid-specific helicase inhibits cervical cancer cells ferroptosis by promoting Nrf2 expression
Authors: Tie Weiwei , Ge Fenfen 
Published: November 2023

Background
Cervical cancer is a major cause of morbidity and mortality in women worldwide. The underlying mechanisms of its progression are not well understood. In this study, we investigated the role of lymphoid-specific helicase (HELLS) in cervical cancer.

Methods
We measured HELLS expression in cervical cancer and assessed its function using gain- and loss-of-function experiments. Cell viability was measured using the Cell Counting Kit-8 (CCK8 ) assay, and cell proliferation was analyzed using colony formation and EdU assays.

Results
We found that HELLS was significantly increased in cervical cancer and that its overexpression promoted cell viability (P < 0.01) and colony formation (P < 0.001). In contrast, si-HELLS suppressed these effects. Moreover, HELLS overexpression inhibited cell death induced by the ferroptosis inducer erastin (P < 0.01). Mechanistically, we found that HELLS promoted cervical cancer proliferation by regulating nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated ferroptosis.

Conclusion
Our data suggest that HELLS promotes cervical cancer proliferation by inhibiting Nrf2 expression. Therefore, HELLS knockdown may be an effective treatment for cervical cancer.
High‐Performance Memristors Based on Few‐Layer Manganese Phosphorus Trisulfide for Neuromorphic Computing
Authors: Weng Zhengjin , Zheng Haofei , Lei Wei , Jiang Helong , Ang Kah‐Wee , Zhao Zhiwei 
Published: November 2023

AbstractWhile transition‐metal thiophosphate (MPX3) materials have been a subject of extensive research in recent years, experimental studies on MPX3‐based memristors are still in their early stages, with device performance being less than ideal. Here, the successful fabrication of high‐yield, high‐performance, and uniform memristors are demonstrated to possess desired characteristics for neuromorphic computing using a single‐crystalline few‐layered manganese phosphorus trisulfide (MnPS3) as a resistive switching medium. The Ti/MnPS3/Au memristor exhibits small switching voltage (<1 V), long memory retention (104 s), fast switching speed (≈20 ns), high On/Off ratio (nearly two orders of magnitude), and simultaneously achieves emulation of synaptic weight plasticity. The microscopic investigation of the structural and chemical characteristics of the few‐layer MnPS3 reveals the presence of structural defects and residual Ti throughout the stacked layer following the application of voltage, which contributes to the uniformity of switching with a low set voltage. With highly linear and symmetric analog weight updates coupled with the capability of accurate decimal arithmetic operations, a high accuracy of 95.15% in supervised learning using the MNIST handwritten recognition dataset is achieved in the artificial neural network. Furthermore, convolutional image processing can be implemented using hardware multiply‐and‐accumulate operation in an experimental memristor crossbar array.
A Safe Separator with Heat‐Dispersing Channels for High‐Rate Lithium‐Ion Batteries
Authors: Yuan Botao , Feng Yuhan , Qiu Xinghan , He Yuhui , Dong Liwei , Zhong Shijie , Liu Jipeng , Liang Yifang , Liu Yuanpeng , Xie Haodong , Liu Zhezhi , Han Jiecai , He Weidong 
Published: November 2023

AbstractSeparators are becoming increasingly important in both academic research and industrial production as a means of enhancing the performance of lithium‐ion batteries (LIBs), particularly at a high rate. However, fast charge–discharge processes will produce local heat accumulation, which accelerates the local reaction rate of Li+ to form lithium dendrites. Commercial polyolefin separators fail to tackle the above issue due to inferior thermal stability. Herein, a core–shell structure is proposed to reinforce the polyvinylidene fluoride‐hexafluoropropylene (PVDF‐HFP) matrix through encircling carbon nanotube (CNT) by adherent polydopamine (PDA). The core–shell 3D structure with PDA avoids the short circuits caused by the electrically conductive CNT, and meantime, the CNT serves as an effective radiator for dispersing local heat sources verified through finite element analysis. The composite separator allows LIBs to achieve high Li+ conductivity (0.49 × 10−3 S cm−1) and Li+ transfer number (0.74), resulting in a high capacity retention of 87.35% after 800 cycles at 5C. In particular, the safety is confirmed that the composite separator avoids violent growth of lithium dendrites caused by local heat accumulation through phase‐field simulations. This work suggests a promising approach for the fabrication of core–shell nanotube composite separators for high‐rate and safe LIBs.
Bandgap Engineering of Two‐Step Processed Perovskite Top Cells for Perovskite‐Based Tandem Photovoltaics
Authors: Pappenberger Ronja , Diercks Alexander , Petry Julian , Moghadamzadeh Somayeh , Fassl Paul , Paetzold Ulrich W. 
Published: November 2023

AbstractFor high‐performance application of perovskite solar cells (PSCs) in monolithic perovskite/silicon tandem configuration, an optimal bandgap and process method of the perovskite top cell is required. While the two‐step method leads to regular perovskite film crystallization, engineering wider bandgaps (Eg > 1.65 eV) for the solution‐based two‐step method remains a challenge. This work introduces an effective and facile strategy to increase the bandgap of two‐step solution‐processed perovskite films by incorporating bromide in both deposition steps, the inorganic precursor deposition (step 1, PbBr2) and the organic precursor deposition (step 2, FABr). This strategy yields improved charge carrier extraction and quasi‐Fermi level splitting with power conversion efficiencies (PCEs) of up to 15.9%. Further improvements are achieved by introducing CsI in the bulk and utilizing LiF as surface passivation, resulting in a stable power output exceeding 18.5% for Eg = 1.68 eV. This additional performance boost arises from enhanced perovskite film crystallization, leading to improved charge carrier extraction. Laboratory scale monolithic perovskite/silicon solar cells (TSCs) (1 cm2 active area) achieve PCEs up to 23.7%. This work marks a significant advancement for wide bandgap two‐step solution‐processed perovskite films, enabling their effective use in high‐performance and reproducible PSCs and perovskite/silicon TSCs.
Structural and Chemical Evolution of Highly Fluorinated Li‐Rich Disordered Rocksalt Oxyfluorides as a Function of Temperature
Authors: Sunariwal Neelam , Dogan Fulya , Roy Indrani , Kumar Khagesh , Nordlund Dennis , Ma Qing , Cabana Jordi 
Published: November 2023

AbstractLi‐rich disordered rocksalt (DRS) oxyfluorides have emerged as promising high‐energy cathode materials for lithium‐ion batteries. While a high level of fluorination in DRS materials offers performance advantages, it can only be achieved via mechanochemical synthesis, which poses challenges of reproducibility and scalability. The definition of relationships between fluorination and structural stability is required to devise alternative methods that overcome these challenges. In this study, the thermal evolution of three highly fluorinated phases, Li2TMO2F (TM = Mn, Co, and Ni), is investigated in an inert atmosphere. Diffraction and spectroscopic techniques are utilized to examine their electronic and chemical states up until conditions of decomposition. The analysis reveals that the materials phase‐separate above 400 °C, at most. It is also observed that heat‐treated DRS materials exhibit intricate changes in the local coordination of the metals, including their spin, and ordering compared to the pristine states. The changes upon annealing are accompanied by a modulation of the voltage profile, including reduced hysteresis, when used as electrodes. These results provide an in‐depth understanding of the fundamental crystal chemistry of DRS oxyfluorides in view of their promising role as the next generation of Li‐ion cathodes.
Insights into Materials, Physics, and Applications in Flexible and Wearable Acoustic Sensing Technology
Authors: Lin Zhiwei , Duan Shengshun , Liu Mingyang , Dang Chao , Qian Shengtai , Zhang Luxue , Wang Hailiang , Yan Wei , Zhu Meifang 
Published: November 2023

AbstractSound plays a crucial role in the perception of the world. It allows to communicate, learn, and detect potential dangers, diagnose diseases, and much more. However, traditional acoustic sensors are limited in their form factors, being rigid and cumbersome, which restricts their potential applications. Recently, acoustic sensors have made significant advancements, transitioning from rudimentary forms to wearable devices and smart everyday clothing that can conform to soft, curved, and deformable surfaces or surroundings. In this review, the latest scientific and technological breakthroughs with insightful analysis in materials, physics, design principles, fabrication strategies, functions, and applications of flexible and wearable acoustic sensing technology are comprehensively explored. The new generation of acoustic sensors that can recognize voice, interact with machines, control robots, enable marine positioning and localization, monitor structural health, diagnose human vital signs in deep tissues, and perform organ imaging is highlighted. These innovations offer unique solutions to significant challenges in fields such as healthcare, biomedicine, wearables, robotics, and metaverse. Finally, the existing challenges and future opportunities in the field are addressed, providing strategies to advance acoustic sensing technologies for intriguing real‐world applications and inspire new research directions.
Engineering a Macroscopic Adhesion System Inspired by Mucilaginous Seeds
Authors: Gürer Ufuk , Usslar Felicitas von , Zollfrank Cordt , Lieleg Oliver 
Published: November 2023

AbstractWet adhesion is a challenging process that requires successful interactions between the two surfaces of interest. Current adhesives may offer sufficient strength but often contain toxic components. Thus, when the field of adhesion meets bioinspiration, there is lots of potential for finding an innovative solution. Here, inspired by mucilaginous seeds and by using refined fiber structures provided by renewable materials, it is demonstrated how to build a comparably strong wet adhesive system. The process involves the controlled fibrillation of a wood surface followed by the application of a macromolecular coating employing the main component found in mucilaginous seeds. Moreover, the additional introduction of a thermo‐responsive polymer into the system allows for obtaining control over the strength and the compliance of the detachment process. Thus, this study demonstrates how combining renewable materials with a multi‐step coating process offers an environmentally friendly solution that pinpoints a promising path toward bio‐based wet adhesives.
In Situ Observation of Perovskite Quantum Dots Driven by Photopolymerization Controlled Using a Digital Micromirror Device
Authors: Tanaka Hayato , Lagzi István , Nakanishi Hideyuki 
Published: November 2023

AbstractPerovskite quantum dots (PQDs) are inherently unstable under environmental conditions, making it difficult to form patterns using conventional techniques. Herein, a unique approach is reported for patterning PQDs by the nonuniform photopolymerization of the liquid monomer. The demonstrated approach employs a PQD‐dispersed photocurable liquid, which is illuminated with the patterned light formed using a digital micromirror device (DMD). As the monomers are photopolymerized, the PQDs in the solution are patterned by diffusion (migration), and eventually, their pattern is imprinted on the film after photopolymerization. The migration process of the PQDs is in situ observed using an inverted‐type confocal microscope, and the patterning principle is examined by fine‐tuning the spatial distribution of the light intensity using the DMD. These findings will promote the generation of clear nanocrystal patterns with high contrasts and narrow line widths on films.