bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice
Authors: Liao Wang , Cao Xinyi , Xia Hui , Wang Shaokang , Chen Liang , Sun Guiju 
Published: December 2023

IntroductionFood proteins have been recognized as an ideal source to release bioactive peptides with the potential to intervene nutrition related chronic diseases, such as cardiovascular diseases, obesity and diabetes. Our previous studies showed that pea protein hydrolysate (PPH) could suppress hepatic glucose production in hepatic cells via inhibiting the gluconeogenic signaling. Thus, we hypothesized that PPH could play the hypoglycemic role in vivo.MethodsIn the present study, the mice model with type 2 diabetic mellitus (T2DM) was developed by high-fat diet and low dose of streptozotocin injections. PPH was administered orally with a dosage of 1000 mg/kg body weight for 9 weeks, followed by the downstream biomedical analyses.ResultsThe results showed that the 9-week treatment of PPH could reduce fasting blood glucose by 29.6% and improve glucose tolerance in the T2DM mice. The associated mechanisms included suppression of the gluconeogenic pathway, activation of the insulin signaling and modulation of the renin angiotensin system in the liver of the diabetic mice. In addition, the levels of pro-inflammatory markers in both liver and serum were reduced by the PPH treatment.ConclusionThe hypoglycemic effect of PPH in T2DM mice was demonstrated in the present study. Findings from this study could provide rationale to incorporate PPH into functional foods or nutraceuticals for glycemic control.
Prognostic significance of HALP score and combination of peripheral blood multiple indicators in patients with early breast cancer
Authors: Zhao Zirui , Xu Lingyun 
Published: December 2023

BackgroundTo assess the prognostic significance of preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score combined with multiple peripheral blood indicators in patients with early breast cancer (EBC).MethodsA total of 411 patients with early invasive breast cancer underwent breast-conserving surgery or radical surgery at Changzhou No.2 People’s Hospital from January 2015 to December 2020. The cut-off values of HALP, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and prognostic nutritional index (PNI) were calculated using the software X-tile. The primary outcomes were recurrence-free survival (RFS), which was analyzed using the Kaplan Meier (K-M) method, while log-rank was used to test the differences between high and low curves. Cox regression analysis was used to analyze the prognostic significance of HALP. Furthermore, the prognostic predictive value of independent prognostic factors was determined using the receiver operating characteristic (ROC) curve.ResultsLow HALP score (P&lt;0.0001), high PLR (P&lt;0.0001), and low LMR (P = 0.0345) were significantly associated with worse RFS. Body mass index (BMI)&lt;24 (P = 0.0036), no diabetes (P = 0.0205), earlier TNM stage (P = 0.0005), and no lymph node metastasis (P = 0.0022) were positively correlated with longer survival HALP scores (hazard ratio [HR] 95% confidence interval [CI]: 0.08 (0.024–0.265), P&lt;0.0001), BMI (HR 95%CI: 0.254 (0.109–0.589), P = 0.001), TNM stage (HR 95%CI: 0.153 (0.041–0.571), P = 0.005), and diabetes (HR 95%CI: 0.259 (0.085–0.785), P = 0.017) were demonstrated as independent prognostic factors by Cox regression analysis. The ROC curves depicted that the two most valuable factors were TNM stage and HALP, and combined independent factors were more accurate in prognostic prediction than any single factor. This further indicated that the TNM stage combined HALP or BMI were more valuable combinations.ConclusionThe HALP score was an independent prognostic factor for EBC and was significantly associated with worse RFS. This score may predict the probability of postoperative tumor recurrence or metastasis before surgery.
Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice
Authors: Dong Wan-Rong , Li Yao-Yao , Liu Tian-Tian , Zhou Gao , Chen Yu-Xin 
Published: December 2023

Background: The Chinese pharmacopeia records Terminalia chebula as effective in treating prolonged diarrhea and dysentery, blood in the stool, and prolapse. Modern pharmacological research proves it has multiple pharmacological benefits, including antioxidant, anti-inflammatory, analgesic, hepatoprotective, neuroprotective, and other properties.Objectives: This study aims to clarify the role of Terminalia chebula’s ethyl acetate extract (TCEA) on ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) in mice, as well as explore the potential mechanism of action.Materials and methods: The variation of different extracts of T. chebula was detected using the HPLC technique, and the main components in TCEA were identified. DSS was used to establish a mouse model to mimic the physiological state of UC in humans; the alleviating effect of TCEA and positive control 5-ASA on UC mice were evaluated by gavage treatment. Disease progression was assessed by monitoring the mouse’s weight change and disease activity index (DAI). The changes in colon tissue were estimated by measuring colon length, HE, and AB-PAS staining and detecting oxidative stress parameters. The results draw from Western blot and real-time PCR showed the TLR4/MyD88/NF-κB pathway may involve in the anti-inflammatory activity of TCEA. Furthermore, the gut flora sequencing technique was employed to monitor the differentiation of intestinal microbiota of mice induced by DSS and TCEA treatment.Results: TCEA significantly lowered DAI scores and inhibited the weight loss and colonic shortening induced by DSS. The colon histomorphology and oxidative stress levels were enhanced after TCEA treatment compared with DSS induced UC group. TCEA attenuated the inflammatory response by regulating TLR4/MyD88/NF-κB pathway activation. Intestinal flora sequencing showed that DSS and TCEA greatly impacted mice’s composition and diversity of intestinal microorganisms. But TCEA increased the abundance of Bacteroidetes and decreased the abundance of Firmicutes and Proteobacteria compared with the DSS group, which contributed a lot to returning the intestinal flora to a balanced state.Conclusion: This study confirms the alleviating effect of TCEA on UC and provides new ideas for developing TCEA into a new drug to treat UC.
NOP58 induction potentiates chemoresistance of colorectal cancer cells through aerobic glycolysis as evidenced by proteomics analysis
Authors: Wang Feifei , Yu Bin , Yu Quanyong , Wang Guanglin , Li Baokun , Guo Ganlin , Wang Handong , Shen Hui , Li Shujin , Ma Chunling , Jia Xianxian , Wang Guiying , Cong Bin 
Published: December 2023

Introduction: The majority of individuals diagnosed with advanced colorectal cancer (CRC) will ultimately acquire resistance to 5-FU treatment. An increasing amount of evidence indicates that aerobic glycolysis performs a significant function in the progression and resistance of CRC. Nevertheless, the fundamental mechanisms remain to be fully understood.Methods: Proteomic analysis of 5-FU resistant CRC cells was implemented to identify and determine potential difference expression protein.Results: These proteins may exhibit resistance mechanisms that are potentially linked to the process of aerobic glycolysis. Herein, we found that nucleolar protein 58 (NOP58) has been overexpressed within two 5-FU resistant CRC cells, 116-5FuR and Lovo-5FuR. Meanwhile, the glycolysis rate of drug-resistant cancer cells has increased. NOP58 knockdown decreased glycolysis and enhanced the sensitivity of 116-5FuR and Lovo-5FuR cells to 5FU.Conclusion: The proteomic analysis of chemoresistance identifies a new target involved in the cellular adaption to 5-FU and therefore highlights a possible new therapeutic strategy to overcome this resistance.
Automatic epileptic seizure detection based on persistent homology
Authors: Wang Ziyu , Liu Feifei , Shi Shuhua , Xia Shengxiang , Peng Fulai , Wang Lin , Ai Sen , Xu Zheng 
Published: December 2023

Epilepsy is a prevalent brain disease, which is quite difficult-to-treat or cure. This study developed a novel automatic seizure detection method based on the persistent homology method. In this study, a Vietoris–Rips (VR) complex filtration model was constructed based on the EEG data. And the persistent homology method was applied to calculate the VR complex filtration barcodes to describe the topological changes of EEG recordings. Afterward, the barcodes as the topological characteristics of EEG signals were fed into the GoogLeNet for classification. The persistent homology is applicable for multi-channel EEG data analysis, where the global topological information is calculated and the features are extracted by considering the multi-channel EEG data as a whole, without the multiple calculations or the post-stitching. Three databases were used to evaluate the proposed approach and the results showed that the approach had high performances in the epilepsy detection. The results obtained from the CHB-MIT Database recordings revealed that the proposed approach can achieve a segment-based averaged accuracy, sensitivity and specificity values of 97.05%, 96.71% and 97.38%, and achieve an event-based averaged sensitivity value of 100% with 1.22 s average detection latency. In addition, on the Siena Scalp Database, the proposed method yields averaged accuracy, sensitivity and specificity values of 96.42%, 95.23% and 97.6%. Multiple tasks of the Bonn Database also showed achieved accuracy of 99.55%, 98.63%, 98.28% and 97.68%, respectively. The experimental results on these three EEG databases illustrate the efficiency and robustness of our approach for automatic detection of epileptic seizure.
Genome-Wide Identification and Expression Analysis of the SWEET Gene Family in Capsicum annuum L.
Authors: Han Xiaowen , Han Shuo , Zhu Yongxing , Liu Yiqing , Gao Shenghua , Yin Junliang , Wang Fei , Yao Minghua 
Published: December 2023

Sugars will eventually be exported transporters (SWEETs) are a novel class of sugar transport proteins that play a crucial role in plant growth, development, and response to stress. However, there is a lack of systematic research on SWEETs in Capsicum annuum L. In this study, 33 CaSWEET genes were identified through bioinformatics analysis. The Ka/Ks analysis indicated that SWEET genes are highly conserved not only among peppers but also among Solanaceae species and have experienced strong purifying selection during evolution. The Cis-elements analysis showed that the light-responsive element, abscisic-acid-responsive element, jasmonic-acid-responsive element, and anaerobic-induction-responsive element are widely distributed in the promoter regions of CaSWEETs. The expression pattern analysis revealed that CaSWEETs exhibit tissue specificity and are widely involved in pepper growth, development, and stress responses. The post-transcription regulation analysis revealed that 20 pepper miRNAs target and regulate 16 CaSWEETs through cleavage and translation inhibition mechanisms. The pathogen inoculation assay showed that CaSWEET16 and CaSWEET22 function as susceptibility genes, as the overexpression of these genes promotes the colonization of pathogens, whereas CaSWEET31 functions as a resistance gene. In conclusion, through systematic identification and characteristic analysis, a comprehensive understanding of CaSWEET was obtained, which lays the foundation for further studies on the biological functions of SWEET genes.
Benefits of Integrating Technology into Home Exercise Therapy in Patients with Lower Extremity Peripheral Artery Disease
Authors: Rotundu Andreea , Oancea Andra , Maștaleru Alexandra , Costache Alexandru-Dan , Cumpăt Carmen Marinela , Abdulan Irina Mihaela , Alexa Anisia Iuliana , Chirica Costin , Russu Mara , Leon Maria Magdalena 
Published: December 2023

(1) Background: Telerehabilitation is an approach that uses digital technology to provide remote medical recovery services. It can be an option for cardiovascular recovery at home in patients with peripheral arterial disease (PAD) of the lower limbs. (2) Methods: We performed literature research through two databases: PubMed and Embase. We included randomized controlled trials and cohort studies that evaluated the effectiveness of a technology-assisted home exercise intervention compared with conventional rehabilitation or the usual care in patients with PAD. We analyzed population, intervention, and outcome data. (3) Results: We identified 2468 studies. After rigorous screening, we included 25 articles in the review. The following results were evaluated: dissemination and acceptance of digital technologies among these people, functional capacity, exercise intensity, patient motivation, sex-specific response differences in mortality and clinical outcomes, quality of life assessment, and changes in values of inflammatory biomarkers. All of these were correlated with the type of intervention and the dose of the exercise. (4) Conclusions: Home-based exercise therapy supervised with the help of specific devices could be successfully implemented in the therapeutic management of the PAD population. Health specialists should take into account the clinical–paraclinical profile and the emotional status of the patients. Such individualized interventions could bring significant benefits for the people with this disease and for the healthcare system, including increasing exercise adherence, engagement, self-care capacity, life expectancy, and quality of life for these patients, as well as reducing their symptoms, cardiovascular complications, and hospitalizations.
Denúncia feita por militar estadual na ouvidoria das polícias versus dever de informar o chefe imediato sobre irregularidade que tomar conhecimento
Authors: Fritola Jorge Aparecido 
Published: December 2023

O presente artigo tem como objetivo uma análise sobre os aspectos legais e doutrinários relacionados ao tema, no intuito específico de esclarecer o cabimento ou não de responsabilização disciplinar do militar estadual da Polícia Militar do Paraná (PMPR) que, devidamente identificado, se vale do canal da Ouvidoria instituída no âmbito da Secretaria de Estado da Segurança Pública do Paraná (SESP/PR) para a apresentação de denúncia sobre irregularidades de que tem conhecimento ou é vítima, desconsiderando por completo o imperativo regulamentar incurso no art. 12 do Decreto nº 4.346, de 26 de Agosto de 2002 (Regulamento Disciplinar do Exército – RDE), que estabelece que todo militar que tiver conhecimento de fato contrário à disciplina, deverá participá-lo ao seu chefe imediato, por escrito, perpassando por nuances dos conceitos de hierarquia e disciplina, lealdade, legalidade, bem como tipicidade das condutas.
Jandarmada Ahlak ve Değer Eğitimi
Authors: DEMİRCİOĞLU İsmail , GÜVEN Onur 
Published: December 2023

Ahlak ve değer eğitimi, toplumların gelişmişlik düzeyini yansıtan önemli göstergelerdendir. Şüphesiz her toplumun kendine özgü değerleri olduğu gibi her mesleğin de kendisini özgün kılan bazı ahlaki ve değer ölçütleri bulunur. Bu kapsamda jandarma mesleği de özellikleri itibariyle diğer mesleklerden ayrılır. Türk jandarması terörle mücadeleden asayişin sağlanmasına, sınır güvenliğinden kaçakçılığa kadar birçok problemle başarıyla mücadele etmektedir. İşte bu başarısının altında ahlak ve değer eğitiminin önemi büyüktür. Bu eğitimlerin yanı sıra yurt sevgisi/bilgisi gibi derslerde vatan sevgisi düsturunu personele kazandırmaktadır.
Kurulduğu günden bugüne hangi rütbede olursa olsun jandarma personeli, nitelikli birer kolluk kuvveti olarak ülke güvenliğine hizmet etmektedir. Şüphesiz bu hizmetin başarılı olabilmesi için sistemli bir eğitim organizasyonu ve hem akademik hem de mesleki bilgi birikim gerekmektedir. Ayrıca bunun yanında ahlaklı, değerlerine bağlı ve yüreği vatan sevgisiyle çarpan personeller yetiştirilmelidir. Bu çerçevede Jandarma Okullarının teşkilatlandığı XX. yüzyılın ilk çeyreğinden 2016 yılında kurulan Jandarma ve Sahil Güvenlik Akademisi’ne kadar geçen süreçte eğitim programları incelendiğinde ahlak, değer ve yurt bilgisi derslerinin bazı dönemlerde müfredata eklendiği ve bu alanlara yönelik konuların önemle üzerinde durulduğu görülmektedir. Bu çalışmada, Erken Cumhuriyet evresinden günümüze jandarma eğitiminde ahlak ve değer eğitimine ne ölçüde yer verildiği, yayımlanan müfredatlar ve çeşitli materyaller aracılığıyla incelemeye tabi tutulmuştur. Neticede jandarma eğitiminde bu konunun önemli bir yer kapladığı sonucuna ulaşılmıştır.
Las tradiciones, el vínculo negador de los derechos de las mujeres
Authors: Venticinque Valeria 
Published: December 2023

Estos trazos pretenden establecer cuáles fueron los desafíos del agenciamiento feminista en Argentina, para garantizar el derecho a la salud de las mujeres en contextos de administraciones conservadoras. En este sentido, nos proponemos describir el vínculo entre las prácticas sanitarias androcéntricas y la negación de las libertades sexuales y (no)reproductivas, en períodos en los que los estilos de gestión se constituyeron de ciertos ejes preponderantes, tales como, la búsqueda de conservar un ordenamiento social y la defensa de cierto tipo de tradiciones presentes en las representaciones societales. Partiremos de suponer que, desde inicios del siglo XX hasta el presente primaron los proyectos tradicionalistas con rasgos liberales clásicos y neoliberales, donde prevaleció el resguardo de un conjunto de creencias y la estratificación social. De esta manera, el presente trabajo trata de buscar respuestas a partir del análisis de fuentes bibliográficas, analizando el vínculo entre los cimientos institucionales de las primeras décadas del siglo XX y las injusticias generadas en el marco del desarrollo de las lógicas neoliberales.
La caracterización conflictiva de la contaminación del río Santiago en El Salto, Jalisco
Authors: Mercier García Heber David 
Published: December 2023

El objetivo de este artículo es identificar cuál enfoque explicativo permite caracterizar el conflicto por la contaminación del río Santiago en el Salto, Jalisco. La finalidad es precisar el marco conceptual que fundamenta su comprensión. Para ello se presentan dos enfoques explicativos del conflicto ambiental, el ecologismo de los pobres y el conflicto de contenido ambiental. Después se muestra históricamente el caso de la contaminación del río Santiago en el Salto. La investigación significó una búsqueda exhaustiva de información en los buscadores de la UDG (Universidad de Guadalajara), Google Scholar, CONRICYT, Scielo, Dialnet y la Plataforma Nacional de Transparencia. Se localizaron cerca de quince fuentes de información, mismas que se diseminaron bajo las siguientes categorías de análisis: “Río Santiago” AND “contaminación”, “Río Santiago” AND “El Salto”, “El Salto” AND “conflicto ambiental”. Se halló que el problema aquí revisado comparte elementos materiales que permiten caracterizarlo desde ambos enfoques.
Pertinencia de la investigación socio-antropológica al fenómeno de la criminalidad compleja
Authors: Bianciotto María Laura 
Published: December 2023

Frente al acuciante contexto donde se produce un incremento de las violencias y las disputas territoriales asociadas al tráfico de drogas ilegalizadas, resulta imperioso trazar nuevos horizontes de articulación con otras disciplinas, o más precisamente con los abordajes vinculados con aquello denominado criminalidad compleja – en tanto involucra diversidad de actores e instituciones. Por tanto, en este artículos nos proponemos realizar un recorrido en torno al enfoque socio-antropológico y de algunas investigaciones y aportes dentro del área de estudios sobre agencias de control social, seguridad y derecho penal. De este modo, pretendemos cimentar nuevos diálogos/intercambios que fortalezcan líneas y escalas de análisis en torno al delito complejo.
Introducción al Dossier. Entre el trabajo y la recreación
Authors: D’Uva Florencia , Martínez Almudevar Paula , Mitidieri Gabriela 
Published: December 2023

Introducción al Dossier Entre el trabajo y la recreación: mundos laborales, entretenimiento y sociabilidad en la Argentina entre los siglos XIX y XX, coordinado por Florencia D’Uva, Paula Martinez Almudevar y Gabriela Mitidieri .
Écritures poétiques modernes et dépaysements dans la langue
Authors: Ducroux Amélie 
Published: December 2023

Cet article tente d’aborder la question du dépaysement dans la langue opéré par l’écriture. La tension possible entre volonté de dire et nécessité d’inventer un nouvel idiome, entre volonté illusoire de se désassujettir de la langue et impossibilité de se départir de la langue, est analysée à la lumière de certaines pratiques d’écriture à même de révéler cette tension. À partir d’une lecture de La Poésie comme expérience, de Philippe Lacoue-Labarthe, et de son commentaire sur Paul Celan, l’article se propose d’interroger ce que la poésie peut faire subir au langage, lorsqu’émerge une parole poétique singulière qui vient creuser son « abîme ». Les possibilités d’émergence d’une parole poétique singulière sont alors interrogées, plus spécifiquement, à la lumière de certaines écritures modernistes anglo-américaines capables de déplacer le sujet de l’écriture dans sa propre langue et de dépayser le lecteur en le confrontant à cette altérité ou en créant un espace où la discontinuité et la dissonance du « discours » mettent en péril toute forme d’ancrage. Une brève analyse d’un texte de Gertrude Stein extrait de Tender Buttons, tente de mettre en évidence une tension entre attention portée à la grammaire et désir d’un rapport au signifiant en tant que pur matériau. Les modalités, différentes, de l’expérience du dépaysement que peut faire le lecteur de The Waste Land, de T.S. Eliot, sont ensuite abordées en termes d’arrachement à tout « pays », de rupture et d’écart. Cet article n’entend nullement rassembler ces poétiques aussi diverses, ni même les comparer, mais simplement esquisser des pistes de réflexion, à partir de la question du dépaysement dans la langue, en s’intéressant notamment à la référentialité, aux possibilités de réinvention et de subversion de la langue et à leurs effets sur le lecteur, ou à l’hermétisme, problématiques liées à la modernité poétique au sens large.