bluuebunny/crossref_metadata_2025_split huggingface dataset:
Typification and nomenclatural notes on four species of Rhynchosia (Leguminosae, Phaseoleae, Cajaninae)
Authors: Mishra Ajay Kumar , Wagh Vijay V. 
Published: February 2024

AbstractDuring revisionary work on the genus Rhynchosia Lour. in India, it was observed that four names need to be typified to stabilize their nomenclatural use. As a result, lectotypes are designated for the four names, namely, Rhynchosia cana (Willd.) DC., R. falconeri Baker, R. filipes Benth., and R. veutina Wight & Arn. The original protologs of these names along with the original herbarium material were evaluated. Nomenclatural remarks discussing the selection of type specimens are given for each name and known isolectotypes are also cited.
Impact of lipase treatment on cuticle wax structure and anthocyanin metabolism in postharvest blueberries
Authors: Ding Mingke , Zong Zihao , Han Yanchao , Wang Lishu , Kong Qi , Chen Hangjun , Xiao Shangyue , Liu Ruiling , Wu Weijie , Gao Haiyan 
Published: February 2024

AbstractIn this paper, we explored the influence of lipase on cuticle wax and anthocyanin metabolism in blueberries. The results demonstrated a progressive alteration in wax crystal structure, transitions from rod‐like to short rod‐like and flaky, and even disappearance of the cuticle wax. Gas chromatography–mass spectrometry analysis revealed a reduction in esters, aldehydes, long‐chain alkanes, and total wax content following lipase treatment of blueberry fruits. Additionally, ultra high performance liquid chromatography–mass spectrometry analysis showed significant decreases in peonidin, petunidin, cyanidin, and delphinidin, accompanied by an increase in malvidin content due to lipase treatment. Subsequent investigations uncovered that lipase treatment inhibited the activities of key anthocyanin synthetic enzymes, namely phenylalanine ammonia‐lyase (PAL), chalcone isomerase (CHI), and dihydroflavonol reductase (DFR). Moreover, lipase treatment downregulated the expression of synthesis‐related genes, including PAL, 4‐coumarate: CoA ligase, chalcone synthase (CHS), CHI, and DFR. In summary, our findings indicate that lipase disrupts the integrity of cuticle wax structure, inhibits anthocyanin synthesis, and reduces anthocyanin content. Accordingly, our studies suggest that inhibiting lipase could offer a novel approach to preserving the freshness and anthocyanin concentration of blueberries.
A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application
Authors: Li Shiyu , Chen Jin , Hao Xiyu , Ji Xiaolong , Zhu Yingying , Chen Xin , Yao Yang 
Published: February 2024

AbstractOwing to concerns about animal proteins, resource limitations, and population growth, there is growing interest in exploring soybeans as animal protein alternatives to fulfill consumption requirements. Black soybean (BS) has superior nutritional and health benefits, compared to yellow soybean (YS). However, BS has been explored less often than YS. While previous reviews have individually focused on the nutritional composition, bioactive compounds, or health benefits of BS, they have not delved into the intricate mechanisms underlying these interactions, especially the distinct roles of the individual components. This comprehensive review aims to bridge this gap by providing an overview of the key nutritional composition and bioactive compounds in BS associated with health benefits, as well as the possible mechanisms underlying these changes. Various processing technologies (physical, biological, and thermal) have been applied to BS. Additionally, the bioavailability, biotransformation, and safety concerns of BS were studied, as these factors are crucial for its potential application, such as natto, films, and microcapsules. However, there are some gaps in the application of BS and YS. In the future, it will be worth exploring the effects of BS protein as meat analogs, 3D printing constituents, and amyloid fibrils, as well as BS lipids as oleogels and BS seed coats as bioactive ingredients in pharmaceutical products.
The relationship between emotional eating, mindful eating, and depression in young adults
Authors: Metin Ziya Erokay , Bayrak Nursena , Mengi Çelik Özge , Akkoca Muzaffer 
Published: February 2024

AbstractThe aim of this study was to examine the relationship between eating behavior, eating awareness, and depression in young adults. Young adults aged between 18 and 25 years were included in the study. Questionnaires and body composition measurements were made face‐to‐face by the researcher in the interview room. The demographic characteristics were questioned through the questionnaire form. Three Factor Eating Questionnaire (TFEQ), Mindful Eating Questionnaire (MEQ), and Beck Depression Inventory (BDI) were used. It was determined that the Mindful Eating Questionnaire total score and Beck Depression Inventory total score affected emotional eating. A statistically significant positive correlation was found between the Beck Depression Inventory total score and the Three Factor Eating Questionnaire sub‐scores. There was a statistically significant negative correlation Beck Depression Inventory total score and the Mindful Eating Questionnaire total score and sub‐scores of mindless eating and emotional eating. In summary, depression seems to be a factor that triggers emotional eating, and emotional eating is a factor that negatively affects mindful eating.
Pyruvate dehydrogenase kinase 2 knockdown restores the ability of amyotrophic lateral sclerosis‐linked SOD1G93A rat astrocytes to support motor neuron survival by increasing mitochondrial respiration
Authors: Miquel Ernesto , Villarino Rosalía , Martínez‐Palma Laura , Cassina Adriana , Cassina Patricia 
Published: February 2024

AbstractAmyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron (MN) degeneration. Various studies using cellular and animal models of ALS indicate that there is a complex interplay between MN and neighboring non‐neuronal cells, such as astrocytes, resulting in noncell autonomous neurodegeneration. Astrocytes in ALS exhibit a lower ability to support MN survival than nondisease‐associated ones, which is strongly correlated with low‐mitochondrial respiratory activity. Indeed, pharmacological inhibition of pyruvate dehydrogenase kinase (PDK) led to an increase in the mitochondrial oxidative phosphorylation pathway as the primary source of cell energy in SOD1G93A astrocytes and restored the survival of MN. Among the four PDK isoforms, PDK2 is ubiquitously expressed in astrocytes and presents low expression levels in neurons. Herein, we hypothesize whether selective knockdown of PDK2 in astrocytes may increase mitochondrial activity and, in turn, reduce SOD1G93A‐associated toxicity. To assess this, cultured neonatal SOD1G93A rat astrocytes were incubated with specific PDK2 siRNA. This treatment resulted in a reduction of the enzyme expression with a concomitant decrease in the phosphorylation rate of the pyruvate dehydrogenase complex. In addition, PDK2‐silenced SOD1G93A astrocytes exhibited restored mitochondrial bioenergetics parameters, adopting a more complex mitochondrial network. This treatment also decreased lipid droplet content in SOD1G93A astrocytes, suggesting a switch in energetic metabolism. Significantly, PDK2 knockdown increased the ability of SOD1G93A astrocytes to support MN survival, further supporting the major role of astrocyte mitochondrial respiratory activity in astrocyte‐MN interactions. These results suggest that PDK2 silencing could be a cell‐specific therapeutic tool to slow the progression of ALS.
Associations of visual, hearing, and dual sensory impairment with motoric cognitive risk syndrome: Observational and Mendelian randomization analyses
Authors: Liang Haixu , Liang Yinhao , Zheng Yixuan , Fang Ya 
Published: February 2024

AbstractBackgroundDementia is associated with individual vision impairment (VI) and hearing impairment (HI). However, little is known about their associations with motoric cognitive risk syndrome (MCR), a pre‐dementia stage. We investigated the association of VI, HI, and dual sensory impairment (DSI) with MCR and to further evaluate causal relationships using Mendelian randomization (MR) approach.MethodsFirst, an observational study was conducted in the China Health and Retirement Longitudinal Study (CHARLS). Evaluate the cross‐sectional and longitudinal associations of VI, HI, and DSI with MCR using the logistic regression models and Cox proportional hazard models, respectively. Second, evaluate the causal association between VI and HI with MCR using MR analysis. The GWAS data was used for genetic instruments, including 88,250 of European ancestry (43,877 cases and 44,373 controls) and 504,307 with “white British” ancestry (100,234 cases and 404,073 controls), respectively; MCR information was obtained from the GWAS with 22,593 individuals. Inverse variance weighted was the primary method and sensitivity analysis was used to evaluate the robustness of MR methods.ResultsIn the observational study, VI (HR: 1.767, 95%CI: 1.331–2.346; p < 0.001), HI (HR: 1.461, 95%CI: 1.196–1.783; p < 0.001), and DSI (HR: 1.507, 95%CI: 1.245–1.823; p < 0.001) were significantly associated with increased risk of MCR. For the MR, no causal relationship between VI (OR: 0.902, 95% CI: 0.593–1.372; p = 0.631) and HI (OR: 1.016, 95% CI: 0.989–1.043; p = 0.248) with MCR risk, which is consistent with the sensitivity analysis.ConclusionVI, HI, and DSI were significantly associated with MCR, but MR analysis failed to provide evidence of their causal relationship. Emphasized the importance of sensory impairment screening in identifying high‐risk populations for dementia.
Clinical characteristics and prognosis of acute myeloid leukemia patients with Runt‐related transcription factor 1 mutation: A single‐center retrospective analysis
Authors: Wang Lin‐Ya , Li Yao , Jiang Qian , Jiang Hao , Wang Yu , Xu Lan‐Ping , Zhang Xiao‐Hui , Liu Kai‐Yan , Tang Fei‐Fei 
Published: February 2024

AbstractThis study aimed to investigate the clinical characteristics and prognosis of Runt‐related transcription factor 1 (RUNX1) mutant acute myeloid leukemia (AML) patients by comparing the features of AML patients with or without RUNX1 mutation. We retrospectively analyzed 180 AML patients including 36 AML patients with mutant RUNX1(AML‐RUNX1mut) and 144 AML patients with wild‐type RUNX1(AML‐RUNX1wt) were selected using the case‐pair method(1:4). Compared to AML‐RUNX1wt, AML‐RUNX1mut showed higher frequency of ASXL1 (p < 0.001), SRSF2 (p < 0.001), BCORL1 (p < 0.001), RAS (p = 0.010) mutations, and absent NPM1 mutations (p = 0.022). The 3‐year overall survival (OS) and disease‐free survival (DFS) of AML‐RUNX1mut and AML‐RUNX1wt were 73.1% versus 68.0% (p = 0.64) and 80.7% versus 71.6% (p = 0.37), respectively. AML‐RUNX1mut receiving allogeneic hematopoietic cell transplantation (allo‐HSCT) showed better survival than those who did not receive allo‐HSCT (3‐year OS, 84.3% vs. 52.7%; p = 0.006). Multivariate analysis showed that EZH2 mutation (p = 0.003), white blood cell (WBC) ≥30 × 109/L (p = 0.036) and age ≥60 years (p = 0.038) were significant independent risk factors for inferior OS of AML‐RUNX1mut; WBC ≥30 × 109/L (p = 0.013) and DNMT3A mutation (p = 0.045) were significant independent risk factors for shorter DFS of AML‐RUNX1mut. In conclusion, AML‐RUNX1mut showed unique clinical characteristics, but the survival between AML‐RUNX1mut and AML‐RUNX1wt were comparable. EZH2 co‐mutation, DNMT3A co‐mutation, old age and high WBC count were associated with inferior survival of AML‐RUNX1mut. Allo‐HSCT can significantly improve the prognosis of AML‐RUNX1mut.
The workforce crisis in healthcare: Moving the debate to bridge evidence and policy
Authors: Kuhlmann Ellen , Lotta Gabriela , Dussault Gilles , Falkenbach Michelle , Correia Tiago 
Published: February 2024

AbstractThis Special Issue aims to advance the healthcare workforce (HCWF) debate by directing its attention to the implementation of policy recommendations and identifying weaknesses. The selection of articles highlights a wide range of HCWF policies and interventions across various countries. The challenges faced often stem from policy failures and governance gaps at the macro‐, meso‐ and micro‐levels of health systems. Recommendations to mitigate the HCWF crisis include interconnected strategies, multi‐/transsectoral policies, solidarity‐based efforts, collaboration, skill‐mix reforms, equity measures, global approaches, and crucially, strong political will. In addition, specific policy solutions are explored, such as community‐centred action and employment of community health workers, mental health support initiatives, inclusion of refugees and displaced healthcare workers into the labour market, and preparing the HCWF for the impact of climate change. This Special Issue calls for transformative HCWF policies and multi‐level transsectoral governance as essential components needed to effectively address the crisis. This will only be possible, if HCWF policy moves higher up in the public policy arena leading, among other things, to the establishment of HCWF research as a distinct academic field.
Substance use‐related problems in mild intellectual disability: A Swedish nationwide population‐based cohort study with sibling comparison
Authors: Påhlsson‐Notini Andreas , Liu Shengxin , Tideman Magnus , Latvala Antti , Serlachius Eva , Larsson Henrik , Hirvikoski Tatja , Taylor Mark J. , Kuja‐Halkola Ralf , Lichtenstein Paul , Butwicka Agnieszka 
Published: February 2024

AbstractBackgroundEvidence for substance use‐related problems in individuals with mild intellectual disability is sparse and mainly limited to selected psychiatric populations. We evaluated the risk of substance use‐related problems in individuals with mild intellectual disability compared to the general population. Additionally, we have performed secondary sibling comparison analyses to account for familial confounding.MethodsWe conducted a population‐based cohort study of individuals born in Sweden between 1973 and 2003. A total of 18,307 individuals with mild intellectual disability were compared to 915,350 reference individuals from the general population and 18,996 full siblings of individuals with mild intellectual disability. Information on mild intellectual disability and substance use‐related problems was obtained from several Swedish national and regional school and healthcare registers. Substance use‐related problems were measured via corresponding diagnostic and legal codes and included alcohol use disorder, drug use disorder, alcohol‐related somatic disease, conviction for a substance‐related crime, and substance‐related death.ResultsIndividuals with mild intellectual disability had a higher risk of any substance use‐related problem compared to the general population (HR, 1.81; 95% CI, 1.72–1.91), both in males (HR, 1.76; 95% CI, 1.65–1.89) and females (HR, 1.89; 95% CI, 1.74–2.05). The risks of substance use‐related problems were particularly elevated among individuals with mild intellectual disability and psychiatric comorbidities (HR, 2.21–8.24). The associations were attenuated in the sibling comparison models.ConclusionsIndividuals with mild intellectual disability, especially those with psychiatric comorbidity, are at an elevated risk of substance use‐related problems. Familial factors shared by full siblings contribute considerably to the association between mild intellectual disability and substance use‐related problems.
Chronic myeloproliferative neoplasm in adulthood in CBL syndrome harboring a splice‐site CBL variant alongside a novel constitutional CSF3R variant
Authors: Mason George , Aghajani Rhian , Dance Brieanna , Othman Jad , Goodwin Linda , Stevenson William , Mackinlay Naomi 
Published: February 2024

AbstractCasitas B‐cell lineage (CBL) syndrome is a rare RASopathy known to predispose to CBL‐mutated juvenile myelomonocytic leukemia (JMML) in childhood. Adulthood acute myeloid leukemia arising out of a genetic aberrancies consistent with prior CBL‐mutated JMML has been twice previously described, but chronic myeloproliferative neoplasia has not. We present a case of progressive myeloproliferative neoplasm in adulthood in the context of CBL syndrome alongside a novel CSF3R variant. We also review pathogenic splice‐site mutations in CBL‐mutated JMML.
Time series prediction of insect pests in tea gardens
Authors: Chen Xuanyu , Hassan Md. Mehedi , Yu Jinghao , Zhu Afang , Han Zhang , He Peihuan , Chen Quansheng , Li Huanhuan , Ouyang Qin 
Published: February 2024

AbstractBACKGROUNDTea‐garden pest control is crucial to ensure tea quality. In this context, the time‐series prediction of insect pests in tea gardens is very important. Deep‐learning‐based time‐series prediction techniques are advancing rapidly but research into their use in tea‐garden pest prediction is limited. The current study investigates the time‐series prediction of whitefly populations in the Tea Expo Garden, Jurong City, Jiangsu Province, China, employing three deep‐learning algorithms, namely Informer, the Long Short‐Term Memory (LSTM) network, and LSTM‐Attention.RESULTSThe comparative analysis of the three deep‐learning algorithms revealed optimal results for LSTM‐Attention, with an average root mean square error (RMSE) of 2.84 and average mean absolute error (MAE) of 2.52 for 7 days’ prediction length, respectively. For a prediction length of 3 days, LSTM achieved the best performance, with an average RMSE of 2.60 and an average MAE of 2.24.CONCLUSIONThese findings suggest that different prediction lengths influence model performance in tea garden pest time series prediction. Deep learning could be applied satisfactorily to predict time series of insect pests in tea gardens based on LSTM‐Attention. Thus, this study provides a theoretical basis for the research on the time series of pest and disease infestations in tea plants. © 2024 Society of Chemical Industry.
Oligosaccharides from black ginseng innovatively prepared by low‐temperature steam‐heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap‐1/Nrf2 pathway
Authors: Xu Weiyin , Yu Peng , Shao Simeng , Xie Zhaoyang , Wu Yi , Liu Jianing , Xu Tianyang , Cai Guangzhi , Yang Hongmei 
Published: February 2024

AbstractBACKGROUNDOur objective in this study was to evaluate the effectiveness of oligosaccharides extracted from black ginseng (OSBG), innovatively prepared by a low‐temperature steam‐heating process, in the improvement of learning and memory impairment in mice, as well as the mechanism(s).RESULTSEight carbohydrates involving isomaltose and maltotetraose were detected in black gensing; monosaccharide residues including mannose and rhamnose were also discovered. OSBG‐treated mice showed significant amelioration in recognition and spatial memory deficits compared to the scopolamine group. OSBG could decrease acetylcholinesterase activity in a tissue‐dependent fashion but not in a dose‐dependent manner. Furthermore, in contrast, OSBG administration resulted in significant upregulation superoxide dismutase, glutathione, glutathione peroxidase (GPx), and Kelch‐like ECH‐associated protein 1, downregulation of malondialdehyde and nuclear factor erythroid 2‐related factor 2 in the tissues. Finally, at the genus level, we observed that the OSBG interventions increased the relative abundance of probiotics (e.g., Barnesiella, Staphylococcus, Clostridium_XlVb) and decreased pernicious bacteria such as Eisenbergiella and Intestinimonas, compared to the Alzheimer's disease mouse model group. Herein, our results demonstrate that OSBG restores the composition of the scopolamine‐induced intestinal microbiota in mice, providing homeostasis of gut microbiota and providing evidence for microbiota‐regulated therapeutic potential.CONCLUSIONOur results showed for the first time a clear role for OSBG in improving scopolamine‐induced memory impairment by inhibiting cholinergic dysfunction in a tissue‐dependent manner. Additionally, OSBG administration relieved oxidative stress by activating the Keap‐1/Nrf2 pathway and modulating the gut microbiota. Collectively, OSBG may be a promising target for neuroprotective antioxidants for improving memory and cognition in Alzheimer's disease patients. © 2024 Society of Chemical Industry.
Association Between Vestibular Aqueduct Morphology and Meniere's Disease
Authors: Huang Yan , Tang Ruowei , Xu Ning , Ding Heyu , Pu Wei , Xie Jing , Yang Zhenghan , Liu Yuhe , Gong Shusheng , Wang Zhenchang , Zhao Pengfei 
Published: February 2024

ObjectiveTo investigate the relationship between vestibular aqueduct (VA) morphology and Meniere's disease (MD) using ultrahigh‐resolution computed tomography (U‐HRCT).MethodsRetrospective data were collected from 34 patients (40 ears) diagnosed with MD in our hospital who underwent temporal bone U‐HRCT with isotropic 0.05‐mm resolution, magnetic resonance with gadolinium‐enhanced, and pure‐tone audiometry; 34 age‐ and sex‐matched controls (68 ears) who underwent U‐HRCT were also included. VA patency was qualitatively classified as locally not shown (grade 1), locally faintly shown (grade 2), or clearly shown throughout (grade 3). The width of the outer orifice and VA length and angle were quantitatively measured. Differences in VA morphology between the MD and control groups were analyzed. The correlations between VA morphology and the degrees of hearing loss and endolymphatic hydrops (EH) were also analyzed.ResultsVA was classified as grades 1–3 in 11, 17, and 12 ears in the MD group and 5, 26, and 37 ears in the control group, respectively. The patency differed significantly between the groups (p < 0.01). The width of the outer orifice and length of VA were significantly smaller in the MD group than those in the control group (p < 0.05). Both VA patency and length were correlated with the degree of EH in the cochlea and the vestibule (p < 0.05). No difference was found between VA morphology and the degree of hearing loss (p > 0.05).ConclusionThe morphological characteristics of VA were found to be associated with the occurrence of MD and the degree of EH.Level of Evidence4 Laryngoscope, 134:3349–3354, 2024
Efficacy of Adjuvant Sublingual Immunotherapy After Septomeatoplasty
Authors: Hsieh Bing‐Han , Kuo Yu‐Chun , Yong Su‐Boon , Tien Hui‐Chi , Hsu Chun‐chieh , Hsu Che‐Lun , Tsou Yung‐An , Lin Chia‐Der , Tai Chih‐Jaan , Wang Jiu‐Yao , Shih Liang‐Chun 
Published: February 2024

BackgroundThe efficacy of adjuvant sublingual immunotherapy (SLIT) in correcting structural problems in patients with allergic rhinitis (AR) caused by mite who have undergone septomeatoplasty (SMP) has not been studied.MethodsThis non‐randomized controlled study recruited patients with AR (caused by mite) and concurrent septal deviation and inferior turbinate hypertrophy, at a tertiary hospital in Taiwan. SMP was performed on all patients as a surgical intervention. The patients were then divided into two groups: the control group, which underwent surgery only, and the experimental group, which received SLIT as an adjuvant treatment. Demographic data and rhinitis control assessment test (RCAT) results were analyzed.ResultsA total of 96 patients were enrolled in the study (SMP + SLIT group, n = 52; SMP only group, n = 44). No significant differences were observed in any of the variables between the two groups before and one month after surgery. However, during evaluations at the third and sixth month, the SMP + SLIT group showed significant improvement in the total RCAT scores compared to the SMP only group (28.6 ± 1.56 vs. 24.5 ± 3.66, p < 0.001; 27.1 ± 2.87 vs. 19.9 ± 5.56, p < 0.001). In addition, significantly better control of all RCAT sub‐categories was observed in the SMP + SLIT group at the third and sixth month evaluations.ConclusionsSLIT may serve as an ideal adjuvant therapy after SMP in patients with AR.Level of Evidence3 Laryngoscope, 134:3073–3079, 2024