bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Clinical Precision Chemotherapy by Patient‐Derived 3D Bioprinting Models of Colorectal Cancer and Its Liver Metastases
Authors: Sun Hang , Sun Lejia , Ke Xindi , Liu Lijuan , Li Changcan , Jin Bao , Wang Peipei , Jiang Zhuoran , Zhao Hong , Yang Zhiying , Sun Yongliang , Liu Jianmei , Wang Yan , Sun Minghao , Pang Mingchang , Wang Yinhan , Wu Bin , Zhao Haitao , Sang Xinting , Xing Baocai , Yang Huayu , Huang Pengyu , Mao Yilei 
Published: November 2023

AbstractMethods accurately predicting the responses of colorectal cancer (CRC) and colorectal cancer liver metastasis (CRLM) to personalized chemotherapy remain limited due to tumor heterogeneity. This study introduces an innovative patient‐derived CRC and CRLM tumor model for preclinical investigation, utilizing 3d‐bioprinting (3DP) technology. Efficient construction of homogeneous in vitro 3D models of CRC/CRLM is achieved through the application of patient‐derived primary tumor cells and 3D bioprinting with bioink. Genomic and histological analyses affirm that the CRC/CRLM 3DP tumor models effectively retain parental tumor biomarkers and mutation profiles. In vitro tests evaluating chemotherapeutic drug sensitivities reveal substantial tumor heterogeneity in chemotherapy responses within the 3DP CRC/CRLM models. Furthermore, a robust correlation is evident between the drug response in the CRLM 3DP model and the clinical outcomes of neoadjuvant chemotherapy. These findings imply a significant potential for the application of patient‐derived 3DP cancer models in precision chemotherapy prediction and preclinical research for CRC/CRLM.
Pearl Memorial Lecture. Humans at the extremes: Exploring human adaptation to ecological and social stressors
Authors: Leonard William R. 
Published: November 2023

AbstractThe field of human biology has long explored how human populations have adapted to extreme environmental circumstances. Yet, it has become increasingly clear that conditions of social stress, poverty, and lifestyle change play equally important roles in shaping human biological variation and health. In this paper, I provide a brief background on the foundational human adaptability research of the International Biological Programme (IBP) from the 1960s, highlighting how its successes and critiques have shaped current research directions in the field. I then discuss and reflect on my own field research that has examined the influence of both environmental and social stresses on human populations living in different ecosystems: the Peruvian Andes, the Siberian arctic, and the Bolivian rainforest. Finally, I consider how the papers in this special issue advance our understanding of human adaptability to extreme conditions and offer directions for future research. Drawing on our field's distinctive evolutionary and biocultural perspectives, human biologists are uniquely positioned to examine how the interplay between social and ecological domains influences the human condition.
Prevalence and risk factors of low birth weight in the United States: An analysis of 2016–2021 data
Authors: Zheng Shimin , Cao Yan , Strasser Sheryl , Wei Holly 
Published: November 2023

AbstractBackgroundLow birthweight (LBW), infants weighing less than 2,500 g, is a global health concern associated with high infant morbidity and mortality rates. This study investigates LBW prevalence and its relation to maternal sociodemographic characteristics and lifestyle behaviors factors in the United States (US).MethodsThis analysis used the National Survey of Children's Health (NSCH) data from 2016 to 2021, including n = 225,443 children aged 0–17 years. 18,131 had LBW (<2,500 g), and 2810 had very LBW (VLBW) (<1,500 g). Logistic regression calculated odds ratios (OR) using LBW as the dependent variable, adjusting for various factors.ResultsBetween 2016 and 2021 in the United States, LBW prevalence averaged 9.31%, with VLBW at 1.50%. Mothers aged 18–35, White, had the lowest LBW (7.63%) and VLBW (1.17%) rates. Mothers aged ≤18 years, black, had the highest LBW (15.45%) and VLBW infants (4.70%). Maternal age emerged as a significant LBW factor, with an OR of 1.27 for ≤18 and 1.19 for >35. Children in poor health had the highest OR (2.87). Race/ethnicity and other disparities were observed.ConclusionOur study highlights LBW risk among non‐White mothers with specific criteria, emphasizing the need for continued exploration of intersectional targets for change that are exacerbating LBW disparities among marginalized populations which may be artificially attributed to biologic determinants and individual‐level risk factors. In‐depth analysis of repressive structures at the root of inequalities demand continued research on macro levels of influence. Customized healthcare reform holds the greatest potential to disrupt the patterns contributing to poor health outcomes among LBW children, and will ultimately maximize the reach and effectiveness of health promotion strategies and clinical practices aimed to improve universal maternal and infant health.
Frequency‐Scanning Considerations in Axionlike Dark Matter Spin‐Precession Experiments
Authors: Zhang Yuzhe , Tumturk Deniz Aybas , Bekker Hendrik , Budker Dmitry , Kimball Derek F. Jackson , Sushkov Alexander O. , Wickenbrock Arne 
Published: November 2023

AbstractGalactic dark matter may consist of axionlike particles (ALPs) that can be described as an “ultralight bosonic field” oscillating at the ALP Compton frequency. The ALP field can be searched for using nuclear magnetic resonance (NMR), where resonant precession of spins of a polarized sample can be sensitively detected. The ALP mass to which the experiment is sensitive is scanned by sweeping the bias magnetic field. The scanning either results in detection of ALP dark matter or rules out ALP dark matter with sufficiently strong couplings to nuclear spins over the range of ALP masses corresponding to the covered span of Larmor frequencies. In this work, scanning strategies are analyzed with the goal of optimizing the parameter‐space coverage via a proper choice of experimental parameters (e.g., the effective transverse relaxation time).
Antiswelling and robust supramolecular polyurea hydrogels induced by the synergy of hydrogen bond and hydrophobic interaction for constructing durable underwater anti‐oil‐fouling coatings
Authors: Li Bengang , Tian Xin , Cao Xuzhi , Luo Zhenyang 
Published: November 2023

AbstractHydrogels are attractive materials for constructing underwater antifouling coatings on solid substrates. However, the application of hydrogel coatings usually faces the obstacles of complex preparation process and poor durability. Herein, we present a facile method to prepare durable hydrogel coatings on metal foils based on rationally designed supramolecular polyurea (PU) hydrogels. PU hydrogels are designed to be cross‐linked with hydrogen bonds (H‐bonds) and hydrophobic interactions in the hard segment domains by using dihydrazides with different alkyl spacer lengths ((CH2)m) as chain extender. The synergy of H‐bond and hydrophobic interaction can stabilize H‐bonds in water, as confirmed by Raman spectroscopy. As a result, PU hydrogels exhibit antiswelling capacity and robustness in both deionized water and seawater. Subsequently, PU hydrogel coatings on Cu/Al foils are prepared by convenient brush coating and subsequent swelling. The resulting hydrogel coatings exhibit excellent underwater anti‐oil‐adhesion and self‐cleaning property, and are durable enough to withstand various static and dynamic damaging tests. The good durability of PU hydrogel coatings should be ascribed to the robust adhesion interface and excellent antiswelling capacity of PU hydrogels. The combination of facile preparation and good durability makes PU hydrogel coatings promising candidates for reliable underwater antifouling.
Magnetic‐field‐induced Fe3O4@CNTs/PES/SPSf composite membrane for efficient removal of methylene blue by adsorption and catalytic degradation
Authors: Ji Yanhong , Zhang Ruonan , Han Zunbo , Jing Ming , Liu Xi , Cai Jiayi , He Benqiao 
Published: November 2023

AbstractNovel composite membranes are successfully developed for adsorption and catalytic degradation of methylene blue (MB) by blending Fe3O4‐coated CNTs (Fe3O4@CNTs) nanoparticles in polyethersulfone (PES) and sulfonated polysulfone (SPSf) matrix via nonsolvent‐induced phase separation (NIPS) method assisted by magnetic field. Fe3O4@CNTs nanoparticles migrate to the separation layer under the induction of magnetic field, thus Fe3O4@CNTs/PES/SPSf composite membranes prepared under magnetic field exhibit a better dye removal ability compared with that without magnetic field. The MB removal ratio by Fe3O4@CNTs/PES/SPSf composite membrane containing 8 wt% Fe3O4@CNTs (M2−M) can reach up to 99% in 30 min under the conditions of 0.25 g composite membrane, 20 mg/L MB, 0.1 mol/L H2O2, pH = 3 and 80°C. Furthermore, the composite membranes show excellent recycling performance, as the MB removal capacity remains at 99% even after four cycles.
Auswirkungen von Verkehrserschütterungen auf jungen Beton: Teil 1
Authors: Gasser Christian , Hausner Lukas , Vorwagner Alois , Klackl Stefanie , Manninger Tanja , Krispel Stefan 
Published: November 2023

AbstractIm Forschungsprojekt COUNT (Concreting under traffic) werden die Auswirkungen von Verkehrserschütterungen auf jungen Beton umfangreich untersucht. Diese Fragestellung hat in letzter Zeit an Relevanz gewonnen. Bei Erneuerungs‐ oder Erweiterungsarbeiten an Brücken müssen oft Verkehrssperren verhängt werden, da man fürchtet, dass die vom Verkehr verursachten Erschütterungen den jungen (aushärtenden) Beton schädigen. COUNT zielt darauf ab, kritische Erschütterungswerte und zugrunde liegende Schädigungsmechanismen anhand von drei Versuchsserien zu ermitteln. Dabei werden sowohl harmonische als auch reale Brückenschwingungen infolge von Zug‐, Lkw‐ und Pkw‐Verkehr angewendet und es werden die Auswirkungen auf sowohl den Werkstoff Beton selbst, als auch auf das Verbundverhalten zwischen Beton und Bewehrung sowie den Kontakt zwischen bestehenden und neuen Betonteilen untersucht. Im vorliegenden ersten Teil des Aufsatzes wird über die Ergebnisse der Versuchsserien 1 und 2 berichtet, bei welchen Kleinkörper während der Erhärtung systematisch durch künstliche Schwingungen angeregt wurden. Dabei wurde festgestellt, dass herkömmliche Verkehrserschütterungen die Festigkeit von Beton an sich nicht beeinträchtigen, jedoch der Verbund zwischen Beton und Bewehrung geschwächt werden kann, wenn die Erschütterungen zu groß sind. Außerdem wurde herausgefunden, dass (differentielle) Verschiebungen sich besser als Beurteilungsgröße eignen als die Schwinggeschwindigkeit.
Brentuximab vedotin in treating Chinese patients with lymphoma: A multicenter, real‐world study
Authors: Zhang Xudong , Qiao Honghan , Chai Xiaofei , Gao Xue , Ma Rongjun , Li Yufu , Zhu Zunmin , Zhang Mingzhi 
Published: November 2023

AbstractBackgroundBrentuximab vedotin (BV) was approved as a therapy for patients with CD30‐positive lymphoma in China in 2020 based on the results of multiple clinical trails. Few Chinese real‐world data of its use are yet available. Herein, we present the application situation of BV in patients with lymphoma among different hospitals in Henan province in China under real‐world conditions.MethodsThis was a multicenter and retrospective study in 104 patients with lymphoma who received BV for the first time between August 2020 and September 2022 across eight centers in Henan province. Data on the clinical use, effectiveness and adverse events (AEs) of BV were extracted from patient medical records. Short‐term effectiveness was assessed based on objective response rate (ORR), complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Progression‐free survival (PFS) and overall survival (OS) were calculated using Kaplan–Meier method. Safety was also evaluated in our study.Results104 lymphoma patients were enrolled in our study, who had completed a median of two cycles (range,1–8) of BV‐based treatment. A total of 72.1% of patients were relapsed/refractory (R/R) lymphoma, and only 27.9% were previously untreated lymphoma who received BV in frontline treatment settings. Among them who received effectiveness evaluation, the ORR achieved 64.5% (CR 25.8%, PR 38.7%). After a median follow‐up of 11 months, the 6‐month PFS rate and OS rate achieved 77.2% and 90.1% respectively, and the 12‐month PFS rate and OS rate achieved 77.2% and 79.9% respectively. In general, BV‐based treatment was well‐tolerated, with 38.5% incidence of grade ≥3 AEs. The most commonly reported AEs were hematologic disorders, especially neutropenia, with the incidence reaching 50.0%.ConclusionsBV‐based regimens could be a promising therapeutic option with remarkable effectiveness and moderate toxicity in treating Chinese lymphoma patients with CD30 expression.
Efficacy of a patient with scar constitution combined with corrosive esophageal strictures after different endoscopic therapies
Authors: Wang Haixia , Tao Wei 
Published: November 2023

Key Clinical MessageOral corrosive substances can cause esophageal or gastrointestinal strictures, leading to malnutrition and gastrointestinal dysfunction, directly affecting the patients' quality of life. The aim of the case was to compare the efficacy of different endoscopic therapy methods.
Coronary‐cameral fistula in an infant patient: An incidental diagnosis
Authors: Velázquez‐Castañeda Raúl , De La Puente‐Tawil Ilana , Molina‐Castillo Sofía , Proaño‐Bernal Leonardo , Rodríguez‐Salazar Mariell Alejandra , Masso‐Bueso Steve , Alexanderson‐Rosas Erick , Arenas‐Fabbri Vincenzo 
Published: November 2023

Key Clinical MessageCoronary artery fistula is a rare abnormal connection between the heart arteries. Patients may remain asymptomatic until adulthood, potentially experiencing life‐threatening complications. Adequate monitoring and therapeutic management are essential.
Surgical orthodontic intervention for impacted maxillary permanent central incisors: A case series
Authors: Jha Kanistika , Adhikari Manoj 
Published: November 2023

Key Clinical MessageImpacted maxillary central incisors represent a relatively infrequent occurrence. This condition significantly impacts the patient's self‐esteem and aesthetic concerns. Effective resolution is achievable through a combined strategy involving surgical exposure, bracket attachment, and subsequent orthodontic extrusion. The Surgical orthodontic approach is the optimal strategy for addressing impacted maxillary central incisors.AbstractCentral incisor is rarely impacted teeth often associated with supernumerary teeth. This case series includes three cases of central incisor impaction presented with complaints of missing teeth, unesthetic appearance, and unclear speech. All the cases were managed with surgical exposure followed by traction by orthodontic force, restoring smile aesthetics.
Clinical response to therapeutic plasmapheresis and intravenous immunoglobulin in pregnancies complicated by alloimmunization despite persistently high titers: Report of two cases
Authors: Bahkali Nedaa , Alhawsawi Ebtihal , Althakafi Kholoud , Arab Kholoud , Rayes Almotasimbellah , Badawi Maha A. 
Published: November 2023

Key Clinical MessagePlasmapheresis and IVIG use in cases of alloimmunization during pregnancy are effective strategies when severe early fetal anemia is anticipated. Despite no change in antibody titer levels before and after plasmapheresis, clinical response was observed in both fetuses, and both had an excellent obstetrical outcome.AbstractHemolytic disease of the fetus and newborn is a potentially lethal complication of alloimmunization, and intrauterine fetal blood transfusion (IUBT) is the standard treatment and care plan for severe fetal anemia. However, IUBT is technically unattainable before 20 weeks of gestation. Plasmapheresis and intravenous immunoglobulin (IVIG) are the two treatment modalities described in the literature that postpone the need for transfusion until after 20 weeks. Here, we present two cases of alloimmunization (one with anti‐Kell and the other with anti‐D). Both had poor outcomes in previous pregnancies because of the early development of severe fetal anemia and hydrops before 24 weeks of gestation. Both patients underwent three sessions of plasmapheresis before 18 weeks, followed by weekly IVIG infusion, which continued until 23–27 weeks of pregnancy. Antibody titers were measured before and after plasmapheresis. In addition, weekly MCA Doppler was performed to monitor the development of severe fetal anemia requiring blood transfusion, which was diagnosed when the peak systolic velocity (PSV) was 1.5 multiples of the median or more. The first patient underwent IUBT at 24 weeks and the second at 28 weeks, as indicated by the MCA Doppler. Both patients were delivered by cesarean section, the first at 34 weeks and the second at 36 weeks, for different obstetrical indications. Both pregnancies resulted in a live birth. We conclude that the use of plasmapheresis and IVIG in alloimmunization during pregnancy is an effective treatment strategy when severe early fetal anemia is anticipated before 20 weeks of gestation. Despite no change in antibody titer levels before and after plasmapheresis, a clinical response was observed in both fetuses, and both had excellent obstetrical outcomes.
Living with chronic progressive external ophthalmoplegia alongside cataract, peptic ulcer disease, diabetes and hypertension in Ghana
Authors: Boi‐Dsane Naa Adzoa Adzeley , Seidu Anwar Sadat , Simon Judith , Bonsaana Gilbert Batieka 
Published: November 2023

Key Clinical MessageThis is the case of a 51‐year‐old woman with chronic progressive external ophthalmoplegia (CPEO) alongside some comorbidities in a low‐resource setting. This report seeks to sensitise clinicians about this rare condition in order to increase their index of suspicion and avoid misdiagnosis.
A rare case with melatonin‐induced on top of alcohol intoxication Brugada type 2 pattern
Authors: Hassan Muad Abdi , Arbab Fatima Khalid , Alsakaji Obada Adel , Dulli Ahmad , Abdow Mohammad Abdow , Ullah Fatima Moulana Mohammed Jamal , Wali Irfan Ullah 
Published: November 2023

Key Clinical MessageBrugada syndrome (BrS), a genetically inherited ion channelopathy, has been linked to a considerable number of unexplained sudden cardiac deaths in patients without structural heart defects, and Brugada phenocopy (BrP) is a condition where there is an identical electrocardiogram (ECG) pattern to a congenital BrS, but this is due to other reversible etiologies. A 37‐year‐old male patient with a documented history of hypertension presented with vomiting after taking 43, 10 mg, melatonin pills and binge drinking locally made alcohol 2 days before. ECG showed right ventricular conduction delay with a “saddleback” appearance, with the J point elevated more than 2 mm and the terminal portion of the ST‐segment elevated more than 1 mm in leads V1 and/or V2. Which returned to normal after a few hours. The association between the use of melatonin and the finding of the Brugada pattern (BP) in a patient with normal heart structure or abnormal ECGs has been documented in much literature, and although no official melatonin dosage is recommended for adults, melatonin has been reported to cause and protect from arrhythmias through different mechanisms. In our patient, after alcohol intoxication was ruled out as a cause, melatonin was the only significant risk factor related to his ECG findings. The BP can be found in patients with otherwise normal heart structure and ECG records, and an overdose of melatonin, which is used as an over‐the‐counter sleep medication, was found to be a possible cause of finding this pattern in these patients after excluding other known causes.
Controlling the Coke Formation in Dehydrogenation of Propane by Adding Nickel to Supported Gallium Oxide
Authors: Baumgarten Robert , Ingale Piyush , Ebert Fabian , Mazheika Aliaksei , Gioria Esteban , Trapp Katharina , Profita Kevin D. , Naumann d'Alnoncourt Raoul , Driess Matthias , Rosowski Frank 
Published: November 2023

AbstractAtomic layer deposition was applied on mesoporous silica to synthesize a highly dispersed gallium oxide catalyst. This system was used as starting material to investigate different loadings of nickel in the dehydrogenation of propane under industrially relevant, Oleflex‐like conditions. The formation of NiGa alloys was confirmed by X‐ray diffraction analysis and electron microscopy. Surprisingly, the nanoalloys enhanced the selectivity towards C3H6 while decreasing the tendency for coking. Herein, in situ thermogravimetry, and measured mass fractions of carbon revealed that the coking rate was reduced by over 50 % compared to the pristine gallium oxide. Generally, the increased selectivity can be explained by the partial hydrogenation and reduction of the gallium oxide surface. The optimum temperature for the removal of deposited carbon was evaluated by a temperature programmed oxidation. Finally, the best‐performing Ni−GaOx catalyst was employed in a cycled experiment with periodic reaction and regeneration tests. After regeneration, the selected Ni−GaOx catalyst provided a higher yield of propylene compared to the unmodified gallium oxide.
Impact of Built‐in Helical Fins on the Performance of Oil‐Gas Cyclone Separators
Authors: Fu Zeming , Wu Huagen , Liang Mengtao , Guo Zhendong , Hou Liang , Xing Ziwen 
Published: November 2023

AbstractAn improved design was proposed by incorporating helical fins onto the vortex finder, and the impact on the comprehensive performance of the oil‐gas cyclone separator was analyzed based on flow field characteristics. The results revealed that the integration of helical fins led to a slight enhancement in the overall separation efficiency and a significant reduction in pressure drop, thus contributing to the decrease of energy consumption in industrial processes. The orthogonal experimental design (OED) method was utilized for the discussion and optimization of five structural parameters related to the helical fins. This study provides new insights for the design of internal components of oil‐gas separators.
Collective Effects of Multiple Fluorine Atoms Causing π‐philic Characteristic within a Caged Polyoxometalate Framework
Authors: Murata Chinatsu , Nakashuku Akari , Shichibu Yukatsu , Konishi Katsuaki 
Published: November 2023

AbstractPerfluorination brings about distinctive properties arising from the unusual nature of the F element, which have been extensively developed in materials science and chemistry. Herein we report that the construction of F‐rich inner space within a hollowed Mo132O372 cage ([Mo132O372(OCOR)30(H2O)72]42−) leads to the emergence of unique guest binding activities in encapsulation. Prominently, the trifluoroacetate‐modified cage (R=CF3, 2) having as many as 90 F groups inside favors trapping cyclopentadiene (Cp), which is hardly trapped by the non‐fluorinated counterpart (R=CH3, 1). Systematic studies using related hydrocarbons show that the amount of the encapsulated guest is correlated with the unsaturation degree of the guests, implying the involvement of the attractive interaction of the CF3‐modified interior wall with the guest π‐electron clouds. Control experiments using the semi‐fluorinated analogues (R=CF2H, CFH2) reveal that the perfluorination is a critical factor to facilitate the Cp encapsulation by 2, indicating that collective effects of polar C−F bonds spreading over the interior surface, rather than the polarity of the individual C−F bonds, are responsible. We also provide a successful example of the physical molecular confinement within the cage through the “ship‐in‐a‐bottle” Diels‐Alder reaction between trapped diene and dienophile.