bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal P‐gp activity is reduced in postmenopausal women under breast cancer therapy
Authors: Ximenez Joao Paulo B. , de Andrade Jurandyr Moreira , Rocha Adriana , Barbosa Coelho Eduardo , Suarez‐Kurtz Guilherme , Lanchote Vera Lucia 
Published: January 2024

AbstractIntestinal P‐glycoprotein (P‐gp) activity plays a crucial role in modulating the oral bioavailability of its substrates. Fexofenadine has commonly been used as a P‐gp probe, although it is important to note the involvement of other drug transporters like, OATP1B1, OATP1B3, and OATP2B1. In vitro studies demonstrated an upregulation of P‐gp protein in response to exposure to pregnancy‐related hormones. The objective of this study was to investigate how intestinal P‐gp activity is impacted by menopausal status. This study sampled fexofenadine plasma concentrations over 0–12 h after probe drug administration from two groups of patients with breast cancer: premenopausal (n = 20) and postmenopausal (n = 20). Fexofenadine plasma concentrations were quantified using liquid‐chromatography tandem mass spectrometry. Area under the plasma concentration‐time curve from zero to infinity (AUCinf) was calculated through limited sampling strategies equation. Multiple linear regression was applied on AUCinf, maximum plasma concentration (Cmax), and time to Cmax. Postmenopausal patients showed a significant increase in Cmax (geometric mean and 95% confidence interval [CI] 143.54, 110.95–176.13 vs. 223.54 ng/mL, 161.02–286.06 and in AUCinf 685.55, 534.98–878.50 vs. 933.54 ng·h/mL 735.45–1184.99) compared to premenopausal patients. The carriers of the ABCB1 3435 allele T displayed higher Cmax values of 166.59 (95% CI: 129.44–214.39) compared to the wild type at 147.47 ng/mL (95% CI: 111.91–194.34, p = 0.02). In postmenopausal individuals, the decrease in P‐gp activity of ~40% may lead to an increased plasma exposure of orally administered P‐gp substrates.
The role of translation equivalents in bilingual word learning
Authors: Tan Alvin W. M. , Marchman Virginia A. , Frank Michael C. 
Published: January 2024

AbstractBilingual environments present an important context for word learning. One feature of bilingual environments is the existence of translation equivalents (TEs)—words in different languages that share similar meanings. Documenting TE learning over development may give us insight into the mechanisms underlying word learning in young bilingual children. Prior studies of TE learning have often been confounded by the fact that increases in overall vocabulary size with age lead to greater opportunities for learning TEs. To address this confound, we employed an item‐level analysis, which controls for the age trajectory of each item independently. We used Communicative Development Inventory data from four bilingual datasets (two English–Spanish and two English–French; total N = 419) for modeling. Results indicated that knowing a word's TE increased the likelihood of knowing that word for younger children and for TEs that are more similar phonologically. These effects were consistent across datasets, but varied across lexical categories. Thus, TEs may allow bilingual children to bootstrap their early word learning in one language using their knowledge of the other language.Research highlights
Bilingual children must learn words that share a common meaning across both languages, that is, translation equivalents, like dog in English and perro in Spanish.
Item‐level models explored how translation equivalents affect word learning, in addition to child‐level (e.g., exposure) and item‐level (e.g., phonological similarity) factors.
Knowing a word increased the probability of knowing its corresponding translation equivalent, particularly for younger children and for more phonologically‐similar translation equivalents.
These findings suggest that young bilingual children use their word knowledge in one language to bootstrap their learning of words in the other language.
Association of Onnia subtriquetra with living and dead bishop pine (Pinus muricata) and shore pine (Pinus contorta var. contorta) in California, USA
Authors: Lee Christopher A. , Hawkins Ashley , Suli Hannah , Belisle Wei , Rooney‐Latham Suzanne 
Published: January 2024

AbstractWe report observations of Onnia subtriquetra on bishop pine (Pinus muricata) and shore pine (Pinus contorta var. contorta) from north coastal California. Our identification of this fungus is supported by molecular information, morphological characteristics, and and a description of the observed range of the fungus on the West Coast. These observations represent an expansion of the geographic and host ranges of Onnia subtriquetra, which on the observed sites is generally associated with declining tree condition and the presence of other native forest pathogens and insects.
Update on monkeypox virus infection: Focusing current treatment and prevention approaches
Authors: Dhapola Rishika , Kumari Sneha , Sharma Prajjwal , KumarKushawaha Pramod , HariKrishnaReddy Dibbanti 
Published: January 2024

AbstractBackgroundWhile the world is still facing the global pandemic COVID‐19, another zoonosis monkeypox (Mpox) has emerged posing a great threat to society. Insight into the pathogenesis, symptoms, and management strategies will aid in the development of potent therapeutics for the treatment of monkeypox virus infection.ObjectivesTo get insight into the current treatment and prevention strategies will aid in effectively coping with the disease.MethodsFor obtaining information regarding the ongoing treatment and prevention strategies and the drugs under pipeline, we referred to Google Scholar, Pub Med, Pub Chem, and WHO official site.ResultsThere are a few drugs that came out to be effective for the treatment of Mpox. Tecovirimat acts by inhibiting viral replication and viral wrapping. Another drug is cidofovir, which hinders the activity of viral DNA polymerase but has the drawback of nephrotoxicity. To overcome this, a conjugate of cidofovir is being used—known as brincidofovir—which has a similar mechanism as cidofovir but lesser toxicity. Ribavirin acts via inhibiting inosine monophosphate dehydrogenase (IMPDPH) thus disrupting viral translation. It also interferes with helicase activity. Tiazofurin, Adenosine N1 oxide, and HPMPA have shown efficacy in in‐vitro studies by inhibiting IMPDH, DNA polymerase, and viral mRNA translation respectively. In‐silico studies have proven the effect of nilotinib, simeprevir, and dihydroergotamine for Mpox treatment. They have shown binding affinity for proteins required for the growth and release of MPXV. Vaccines have also been employed for the prevention of Mpox, which includes JYNNEOS, ACAM2000, and VIGIV.ConclusionThis review highlights the pathogenesis of the virus, disease manifestations, drugs, and vaccines that are being used and those under pipeline for the treatment and prevention of Mpox.
Patient partner perspectives on compensation: Insights from the Canadian Patient Partner Survey
Authors: Dhamanaskar Roma , Tripp Laura , Vanstone Meredith , Canfield Carolyn , Levasseur Mary Anne , Abelson Julia 
Published: January 2024

AbstractIntroductionThere is a growing role for patients, family members and caregivers as consultants, collaborators and partners in health system settings in Canada. However, compensation for this role is not systematized. When offered, it varies in both type (e.g., one‐time honorarium, salary) and amount. Further, broad‐based views of patient partners on compensation are still unknown. We aimed to describe the types and frequency of compensation patient partners have been offered and their attitudes towards compensation.MethodsThis study uses data from the Canadian Patient Partner Study (CPPS) survey. The survey gathered the experiences and perspectives of those who self‐identified as patient partners working across the Canadian health system. Three questions were about compensation, asking what types of compensation participants had been offered, if they had ever refused compensation, and whether they felt adequately compensated. The latter two questions included open‐text comments in addition to menu‐based and scaled response options. Basic frequencies were performed for all questions and open‐text comments were analyzed through inductive qualitative content analysis.ResultsA total of 603 individuals participated in the CPPS survey. Most respondents were never or rarely offered salary (81%), honorarium (64%), gift cards (80%) or material gifts (93%) while half were offered conference registration and expenses at least sometimes. A total of 129 (26%) of 499 respondents reported refusing compensation. Of 511 respondents, half felt adequately compensated always or often, and half only sometimes, rarely or never. Open‐text comments revealed positive, ambivalent and negative attitudes towards compensation. Attitudes were framed by perceptions about their role, sentiments of giving back to the health system, feelings of acknowledgement, practical considerations, values of fairness and equity and accountability relationships.ConclusionsOur findings confirm that compensation is not standardized in Canada. Half of survey respondents routinely feel inadequately compensated. Patient partners have diverse views of what constitutes adequate compensation inclusive of personal considerations such as a preference for volunteering, and broader concerns such as promoting equity in patient partnership. Organizations should attempt to ensure that compensation practices are clear, transparent and attentive to patient partners' unique contexts.Patient ContributionTwo patient partners are members of the CPPS research team and have been fully engaged in all study phases from project conception to knowledge translation. They are co‐authors of this manuscript. The survey was co‐designed and pilot tested with patient partners and survey participants were patient partners.
Investigating the impact of sebum secretion on liquid makeup foundation darkening and its solution
Authors: Zhang Qi , Chen Gang , Hou Yifan , Wang Sijing , Xia Qianru , Yu Jing 
Published: January 2024

AbstractObjectivesDarkening has been an issue of concern for foundation products. The secretion of sebum plays a significant role in the process of foundation darkening, but the underlying mechanisms and solutions have been rarely reported. The aim of this study was to explore the relationship between sebum secretion and liquid foundation darkening and to provide possible solutions for reducing sebum‐induced darkening in liquid foundation.MethodsArtificial sebum in different concentrations was added to a basic liquid foundation to simulate different stages of sebum secretion. The colour of the mixture was then measured by a spectrophotometer on the standard opacity chart. Potential technical solutions for anti‐darkening were applied to a basic liquid foundation, and its ability to anti‐darkening was further verified in vivo.Results(1) The influences of sebum addition on liquid foundation darkening had a significant positive correlation with the increase in transmissivities (R2 = 0.852, p < 0.01). (2) A certain range of sebum addition can reduce the darkening of volatile foundations. (3) The liquid foundations using pigments with high dispersibility in sebum were less influenced by sebum. (4) The replacement of pigments with oil‐fixing ability could effectively reduce the darkening of liquid foundations induced by sebum (p < 0.01).ConclusionThe effect of sebum on the darkening of liquid foundation was accompanied by a greater transmissivity as its pigment concentration decreased. Balanced volatility, the addition of powders with higher sebum dispersibility and the replacement of oil‐fixing powders could reduce the darkening of the liquid foundation caused by sebum secretion.
How workers meet new expertise needs throughout their careers: An integrative review revealing a dynamic process model of flexpertise
Authors: Frie Lonneke S. , Van der Heijden Beatrice I. J. M. , Korzilius Hubert P. L. M. , Sjoer Ellen 
Published: January 2024

AbstractIn expertise research, the focus is shifting from how one becomes an expert in a specific field towards understanding how workers sustain the value and recognition of their expertise by being flexible. This so‐called flexpertise requires that workers meet new expertise needs within and across the boundaries of their current expertise domains and working contexts. The current study grounds a new theoretical paradigm regarding this individual adaptivity by introducing a ‘dynamic process model of flexpertise’. By deploying a system dynamics lens, it synthesizes the scholarly knowledge from different disciplines about flexible or adaptive forms of expertise. The model incorporates six categories of adaptation processes that involve intra‐individual changes and social interactions over time, and that are interconnected by means of feedback loops without a single start‐ or endpoint. This enables scholars and practitioners to identify leverage points where small interventions can have a large effect on the individual's adaptivity. As such, the dynamic model provides a new paradigm on how to foster workers’ continued possession of expertise that is valuable to organizations’ competitive advantage and enables organizational and societal transitions and innovations, while safeguarding an individual's career sustainability.
Perceived algorithmic fairness: An empirical study of transparency and anthropomorphism in algorithmic recruiting
Authors: Ochmann Jessica , Michels Leonard , Tiefenbeck Verena , Maier Christian , Laumer Sven 
Published: January 2024

AbstractDespite constant efforts of organisations to ensure a fair and transparent personnel selection process, hiring is still characterised by systematic inequality. The potential of algorithms to produce fair and objective decision outcomes has attracted the attention of academic scholars and practitioners as a conceivable alternative to human decision‐making. However, applicants do not necessarily consider an objective algorithm as fairer than a human decision maker. This study examines the conditions under which applicants perceive algorithms as fair and establishes a theoretical foundation of algorithmic fairness perceptions. We further propose and investigate transparency and anthropomorphism interventions as strategies to actively shape these fairness perceptions. In an online application scenario with eight experimental groups (N = 801), we analyse determinants for algorithmic fairness perceptions and the impact of the proposed interventions. Embedded in a stimulus‐organism‐response framework and drawing from organisational justice theory, our study reveals four justice dimensions (procedural, distributive, interpersonal, informational justice) that determine algorithmic fairness perceptions. The results further show that transparency and anthropomorphism interventions mainly affect dimensions of interpersonal and informational justice, highlighting the importance of algorithmic fairness perceptions as critical determinants for individual choices.
RETRACTED: Effects of quality nursing on the surgical site wound infections in patients undergoing cardiothoracic surgery: A meta‐analysis
Authors: Lv Xiuhong , Zhou Anyi , Chen Min , Qi Chunhua , Zhang Qiwen 
Published: January 2024

AbstractThe aim of this study is to systematically evaluate the effects of quality nursing on wound infections and postoperative complications in patients undergoing cardiothoracic surgery. Computerised searches of the PubMed, Web of Science, Cochrane Library, Embase, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang databases were conducted from database inception to October 2023 for randomised controlled trials (RCTs) on the application of quality nursing to patients undergoing cardiothoracic surgery. The studies were screened and evaluated by two researchers based on the inclusion and exclusion criteria, and data were extracted from the included studies. Stata software (version 17.0) was used for all analyses performed. A total of 18 RCTs and 1742 patients were included, including 972 in the quality nursing group and 870 in the routine nursing group. The analysis revealed that compared with routine nursing, patients undergoing cardiothoracic surgery who received quality nursing care were significantly less likely to experience postoperative wound infections (OR = 0.31, 95% CI: 0.19–0.51, p < 0.001) and complications (OR = 0.24. 95% CI: 0.17–0.33, p < 0.001). The implementation of quality nursing in clinical care after cardiothoracic surgery can effectively reduce the incidence of wound infections and postoperative complications, and is worthy of promotion and clinical application.
A review on wound management strategies in enhanced recovery after craniotomy: An in‐depth analysis of their influence on patient recovery and surgical outcomes
Authors: Wu Nan , Li Luping 
Published: January 2024

AbstractCraniotomy, an essential neurosurgical operation, poses distinct difficulties in the realm of post‐operative care, specifically with regard to the management of wounds. Efficient wound management is critical in order to optimize the surgical outcomes, reduce complications and facilitate a speedier recovery. The purpose of this comprehensive review was to assess contemporary wound management approaches as they pertain to improved recovery following craniotomy. This was achieved by contrasting conventional methods with more recent and innovative techniques and analysing the effects of these approaches on patient recovery and surgical results. An exhaustive literature search was undertaken, comprising narrative reviews, clinical studies, peer‐reviewed articles and expert opinions. The emphasis was on the evolution of wound management strategies and techniques utilized after cranial section, as well as their contributions to patient recovery. The analysis reveals that while conventional wound management methods, including suturing and antiseptics, continue to be essential, innovative strategies such as negative pressure wound therapy, skin adhesives and advanced pain management protocols are becoming increasingly recognized. It has been demonstrated that these novel approaches improve recovery by decreasing the incidence of infections, enhancing patient comfort and producing superior cosmetic results. Nevertheless, obstacles continue to endure, including patient‐specific variables, technological and financial considerations and the enduring consequences of recovery. Thus the treatment of wounds during craniotomy recuperation necessitates an integrated strategy that incorporates conventional techniques alongside contemporary advancements. Progress in this domain necessitates the customization of approaches to suit the unique requirements of each patient, the resolution of identified obstacles and an emphasis on ongoing investigation and interdisciplinary cooperation. The ever‐changing terrain of wound management approaches underscores the ever‐changing character of neurosurgical treatment and the continuous endeavour to enhance patient results following cranial resection.
State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding
Authors: Feng Changsheng , Yang Liang 
Published: January 2024

AbstractTraumatic haemorrhage is a prevalent clinical condition, and effective and timely haemostasis is crucial for the preservation of patients' lives. In recent years, injectable hemostatic materials have gained significant attention due to their excellent hemostatic efficacy, biocompatibility, and biodegradability, making them widely applied in the treatment of incompressible traumatic haemorrhage. Systematic analysis of injectable hemostatic materials is crucial for research in this area. This article provides a comprehensive review of the development and research trends of injectable hemostatic materials over the past 20 years using visualization techniques. Analysis of collaboration and co‐citation networks revealed localized research collaboration networks, highlighting the need for enhanced international collaboration in the field of injectable hemostatic materials. Current research focuses primarily on hemostatic materials, hemostatic processes, and hemostatic mechanisms. Injectable hemostatic materials with excellent performance offer promising strategies for wound healing. This review provides a comprehensive and systematic summary of injectable hemostatic materials, offering valuable guidance for the development and clinical application of novel injectable hemostatic materials. Additionally, visualized methodology and mapping analysis are effective data mining methods that provide approaches and strategies for clear knowledge network analysis. These methods facilitate better understanding and interpretation of research dynamics in the field of injectable hemostatic materials, thereby guiding and inspiring future research.
Developing an early warning system for detecting sepsis in patients with trauma
Authors: Guo Kucun , Pan Bao , Zhang Xinliang , Hu Dezheng , Xu Guangyue , Wang Lin , Dong Shimin 
Published: January 2024

AbstractThe purpose of this study was to analyse the risk factors for sepsis in patients with trauma and develop a new scoring system for predicting sepsis in patients with trauma based on these risk factors. This will provide a simple and effective early warning method for the rapid and accurate detection and evaluation of the probability of sepsis in patients with trauma to assist in planning timely clinical interventions. We undertook a retrospective analysis of the clinical data of 216 patients with trauma who were admitted to the emergency intensive care unit of the emergency medicine department of the Hebei Medical University Third Hospital, China, between November 2017 and October 2022. We conducted a preliminary screening of the relevant factors using univariate logistic regression analysis and included those factors with a p value of <0.075 in the multivariate logistic regression analysis, from which the risk factors were screened and assigned, and obtained a total score, which was the sepsis early warning score. The incidence of sepsis in patients in the intensive care unit with trauma was 36.9%, and the mortality rate due to sepsis was 19.4%. We found statistically significant differences in several factors for patients with sepsis. The risk factors for sepsis in patients with trauma were the activated partial thromboplastin time, the New Injury Severity Score, growth differentiation factor‐15 levels, shock, mechanical ventilation and the Acute Physiology and Chronic Health Evaluation II score. The area under the receiver operating characteristic curve of the sepsis early warning score for predicting sepsis in patients with trauma was 0.725. When the cutoff value of the early warning score was set at 5.0 points, the sensitivity was 69.9% and the specificity was 60.3%. The incidence of sepsis in patients with trauma can be reduced by closely monitoring patients' hemodynamics, implementing adequate fluid resuscitation promptly and by early removal of the catheter to minimize the duration of unnecessary invasive mechanical ventilation. In this study, we found that the use of the sepsis early warning score helped in a more accurate and effective evaluation of the prognosis of patients with trauma.