bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilizing C. elegans Spermatogenesis and Fertilization Mutants as a Model for Human Disease
Authors: Perez Sofia M. , Augustineli Helena S. , Marcello Matthew R. 
Published: January 2025

The nematode C. elegans is a proven model for identifying genes involved in human disease, and the study of C. elegans reproduction, specifically spermatogenesis and fertilization, has led to significant contributions to our understanding of cellular function. Approximately 70 genes have been identified in C. elegans that control spermatogenesis and fertilization (spe and fer mutants). This review focuses on eight genes that have human orthologs with known pathogenic phenotypes. Using C. elegans to study these genes has led to critical developments in our understanding of protein domain function and human disease, including understanding the role of OTOF (the ortholog of C. elegans fer-1) in hearing loss, the contribution of the spe-39 ortholog VIPAS39 in vacuolar protein sorting, and the overlapping functions of spe-26 and KLHL10 in spermatogenesis. We discuss the cellular function of both the C. elegans genes and their human orthologs and the impact that C. elegans mutants and human variants have on cellular function and physiology. Utilizing C. elegans to understand the function of the genes reviewed here, and additional understudied and undiscovered genes, represents a unique opportunity to understand the function of variants that could lead to better disease diagnosis and clinical decision making.
Crues et structures souterraines de drainage des plateaux jurassiques du Nord-Est de la France
Authors: Fister Vincent , Losson Benoît , Lebaut Sébastien , Gille Emmanuel , Manceau Luc 
Published: January 2025

Floods and underground structures of drainage of the jurassic plateaus of the Northeast of France.

The hydrodynamic functioning of an outlet during floods is governed by the external precipitation forcing and internal control imposed by the drainage structure. Observe and analyze the floods returns to "zoom in" on the drainage characteristics of the monitored systems and, consequently, to refine the understanding of water circulations. It is in this perspective that we decided to follow up hydroclimatic and geochemical variables during various floods the level of four outlets in order to identify and quantify the components of the flow in the low limestones plateaus of the Northeast of France. Through characteristics times, types of water and volumes that illustrate the propagation of the flood wave during hydrological crisis, this is the organization of the rainfall-runoff relationship in the underground drainage structures that is seen at a fine scale. Following the analyses, two types of hydrodynamic behavior are identified :
-in the case where the outlet is supplied in part by rapid infiltration morphologies. Infiltration is concentred and benefits to the drainage structuring in unsaturated zone and satured zone. The karst porosity is proved by sudden hydrogeochemical variations during major rainfall ;
-in the case where the outlet is exclusively supplied by diffuse infiltration. The structures of drainage are not very functional, and flood processes are very slow in response to horizontal and vertical transits which occur in narrow discontinuities systems.
Fantômisation et spéléogenèse : implications et questionnement
Authors: Quinif Yves 
Published: January 2025

Ghost rock karstification and speleogenesis, implications and questions.
The concept of the ghostrock karstification could be demonstrated through three groups of observations. (1) The paleokarsts in Carboniferous carbonates of Hainaut seen in the quarries of Soignies and Tournai constitute ghost-rocks largely still filled with their residual alterite in subterranean forms having strong ties of kinship with traditional endokarstic forms. (2) The “improbable” cave in the Clypot quarry (Soignies) contains a river sedimentary series that erodes the in situ residual alterite of an endokarstic ghost-rock. This series is dated from the Dano-Montien. We have thus the passage between a ghosttype karst to a cave. (3) The observed visual emptying of an endokarstic ghost-rock in the Nocarcentre (Ecaussinnes) quarry was caused by the erosion of residual alterite due to an underground river from the water table surrounding this quarry-pit. This phenomenon constitutes a real experience of the passage from the ghost-rock to the speleological cave. The phenomenon being no longer in doubt, it remains to demonstrate in each case the origin of the speleological karst : does it come from a ghost-rock or a karstification by total removal ? Several facts are striking, notably the genesis of several subterranean microforms characteristic in a context of ghost-rock karstification, thus requiring great caution in their genetic interpretation : can we keep a causal link between the genetic factors and the resulting forms on the basis of traditional concepts ? Here we examine examples of caves where the search for ghost-rocks may have led to their discovery despite the violent and prolonged erosion of galleries by underground river flows (Han-sur-Lesse, Azé cave, Entre-deux-Mers, Charente’s karst). Then, karstification by ghost-rock karstification in Belgium is put back into regional geological history by evoking the application to other karstic systems. We end by the possible generalization of the ghost-rock karstification to all the karstic systems.
Les aménagements préhistoriques de l’aven de Sot Manit (Saint-Maurice-Navacelles, Hérault)
Authors: Bigot Jean-Yves 
Published: January 2025

The prehistoric installations of the Aven de Sot Manit (Saint-Maurice-Navacelles, Hérault).
The Aven de Sot Manit is a cave on the southern border of the Causse du Larzac. The shaft cave, visited in prehistoric times, was explored in 1937 and partially looted in the years after its (re) discovery. The authorities in charge of archeology then ordered the last pots to be removed. This is why today, there are almost no (removable) traces of human occupancy of the cave from neolithic times. The presence of spectacular floor notches led to speculations about a second entrance, however, some more throrough research revealed artificial installations to retain or divert water into different recipients, either ceramics or natural or artificial basins. In the cave, the water drops from the ceiling as rain and forms two small rivulets that follow the natural gradient. They had been deviated by different structures, such as a large basin that is blocked by a large speleothem block. From that place, the water has been redirected to a lower basin which was dammed by the ancient explorers. Detailed observation of the broken rim of the natural basins permitted ideas on the emptying technique used. The presence of a path leading from the bottom of the shaft towards the basins points to a complete equipment of the cave.
La grotte du Pont d’Arcole (Hastière, Belgique) Dépôts et relation avec l’enfoncement de la Meuse
Authors: Quinif Yves , Blockmans Sabine , Verheyden Sophie , Delaby Serge , Cheng Hai , Edwards Laurence R. 
Published: January 2025

<i>The cave of the Pont d’Arcole
(Hastière). Deposits and relation with the sinking of the Meuse</i>.

The Pont d’Arcole cave develops in the limestones of the Dinant basin. The strata are positioned vertically. The cave is located in the valley of the Féron River, tributary of the Meuse River, where it constitutes an underground autocapture of the river. Two galleries connect the upper and lower parts of the cave through a topographically complex zone with a vertical dominance. The upper gallery is a rather straight tunnel between two openings ; it consists of an underground meander cut-off that follows the vertical bedding planes. The walls are carved with scallops and longitudinal channels on the vault. The lower gallery is hollowed out either at the expense
Les gorges de la Cèze. Élaboration d’un modèle chronologique à partir des données géologiques : conséquences sur l’hydrogéologie
Authors: Chapuis Hervé , Ré-Bahuaud Jordan , Jolivet Joël , Graillot Didier 
Published: January 2025

The gorges of the river Cèze -Development of a chronological model based on geological data : implications for hydrogeology.
The content presented in this article is an integral part of the research work carried out with the aim of characterizing, evaluating and modeling the exchanges between the Cèze River and its karstic system that it crosses in the middle part of the valley [ Chapuis, 2017]. This paper presents the Cèze watershed with a lithological description of the terrain to lead to a chronological model in order to better understand the implication on the flow of water. Geological analysis reveals a significant diversity of watershed-wide formations in its downstream portion, leading to the identification of shifting hydrological boundaries over time. Through the threedimensional representation of the study area as a chronological model, there is a structural evolution of the lower Cretaceous limestone from its setting up to the orogenic phases of the Miocene. The analysis of this complex geology, combined with successive tectonic deformations, provides a better understanding of the current arrangement of karst aquifers in the studied area. From the western edge of the Alès graben to the upper Cretaceous formations east of the plateau of Méjannes-le-Clap, geological formations capable of infiltrating surface waters are emerging. These infiltrated waters can be directly connected to the exutory of karst springs by the karstic network itself. However, it is possible that these springs do not return all of the infiltrated waters. This groundwater could therefore have flow beyond the boundaries of the study area and reaches the eastern Rhone Valley.
Efektivitas Terapi Otot Progresif dalam Mengurangi Kram Otot pada Pasien Hemodialisa di RSAU Dr. Esnawan Antariksa
Authors: Deannova Farrel Chandra , Harwina Widya Astuti  , Sinta Fresia  
Published: January 2025

Gagal ginjal kronis adalah kondisi dimana peran ginjal menurun dan tidak dapat diperbaiki penyakit ini banyak diderita orang di dunia. Di Indonesia sendiri pada tahun 2018 terdapat 66.433 pasien baru. Salah satu terapi untuk penyakit gagal ginjal kronis adalah hemodialisa. Salah satu masalah yang kerap dirasakan oleh pasien hemodialisa adalah kram otot, sebanyak 46,9% pasien hemodialisa mengalami kram otot. Dalam mengurangi kram otot diperlukan teknik non-farmakologi, yaitu terapi otot progresif. Tujuan penelitian ini adalah untuk mendeskrisikan kram otot sebelum dan sesudah dilakukan Terapi Otot Progresif pada pasien yang menjalani hemodialisa di RSAU Dr. Esnawan Antariksa. Desain penelitian ini adalah deskriptif dengan studi kasus. Penelitian ini menggunakan 2 subyek penelitian. Instrumen penelitian ini dengan alat ukur yang digunakan adalah Cramp Questionnaire Chart. Hasil penelitian ini menunjukan bahwa terdapat penurunan skor kram otot dengan klasifikasi kram sedang menjadi kram ringan. Kesimpulan penelitian ini adalah terapi otot progresif dapat menurunkan skor kram otot pada pasien yang menjalani terapi hemodialisa.

Chronic kidney failure is a condition where the function of the kidneys decreases and cannot be repaired. This disease affects many people in the world. In Indonesia alone, in 2018 there were 66,433 new patients. One of the therapies for chronic kidney failure is hemodialysis. One of the problems often experienced by hemodialysis patients is muscle cramps. As many as 46.9% of hemodialysis patients experience muscle cramps. To reduce muscle cramps, non-pharmacological techniques are needed, namely progressive muscle therapy. The aim of this study was to describe muscle cramps before and after Progressive Muscle Therapy in patients undergoing hemodialysis at RSAU dr. Esnawan Antariksa. This research design is descriptive with a case study. This study used 2 research subjects. The research instrument used for this research is the Cramp Questionnaire Chart. The results of this study showed that there was a decrease in muscle cramp scores with the classification of moderate cramps to mild cramps. The conclusion of this study is that progressive muscle therapy can reduce muscle cramp scores in patients undergoing hemodialysis therapy.
EFICÁCIA DE TRATAMENTOS ENDODÔNTICOS REGENERATIVOS EM DENTES MADUROS E IMATUROS COM NECROSE PULPAR
Authors: Vasconcelos Maria Eduarda Darigo , Ferreira Ana Karinne da Silva , Santos André Luiz Campos dos , Oliveira Antônio Marcos Barboza de , Bôa-Morte Graziella Valda Oliveira Sousa , Santos Ingrid Carla Mascarenhas , Silva João Henrique Martins Fernandes da , Santos Juliana Patrícia Barboza , Vasconcelos Raylana Vitória da Silva , Fidelis Renata Lira do Nascimento , Reis Rodrigo Cavalcante de Albuquerque , Amaral Romaiana Máximo Rodrigues do , Paula Samantha Soares de , Oliveira Vanessa Maria Alves da Silva Pereira 
Published: January 2025

Objetivos: Avaliar a eficácia dos tratamentos endodônticos regenerativos em dentes maduros e imaturos, necrosados e/ou com periodontite apical, e comparar com o tratamento endodôntico convencional. Revisão de literatura: Trata-se de uma revisão de literatura que foi realizada entre dezembro de 2024 e janeiro de 2025, a pergunta que norteou a busca foi “Os procedimentos endodônticos regenerativos são eficazes para a terapia de dentes necrosados?”. A partir disso, foi feita a busca nas bases de dados PubMed (U.S. National Library of Medicine) e BVS (Biblioteca Virtual em Sa ̇de), com lapso temporal de 5 anos. A estratégia de busca foi formulada pela conjugação dos descritores indexados no DeCS/MeSH “Necrose da polpa dentária”, “Periodontite Apical” e “Endodontia Regenerativa”, combinados ao operador booleano “AND”. Os critérios de seleção foram: estudos publicados nos últimos 5 anos, que estivessem relacionados com a pergunta norteadora, com texto completo disponível em português, inglês e espanhol, revisões sistemáticas de literatura, metanálises e ensaios clínicos randomizados. A busca inicial resultou na identificação de 183 artigos. Destes, 07 artigos foram incluídos na pesquisa. Conclusão: Os tratamentos endodônticos regenerativos (REPs) são eficazes para dentes com necrose pulpar, promovendo cicatrização e desenvolvimento radicular. Apesar de promissores, enfrentam desafios como descoloração da coroa e limitada organização do tecido regenerado.
Gender Digital Divide and Education: A Reflection from the University of Nairobi, Kenya
Authors: Muasya Juliet Njeri 
Published: January 2025

The use of digital technology safely and effectively is increasingly becoming important. Moreover, since the onset of the COVID-19 pandemic, digital technological skills have continued to transform the educational landscape, bringing a wide range of benefits to both students and teachers. This requires both men and women students and teachers to know how to use digital devices and connectivity tools for high-quality and future-focused teaching and learning processes. The objective of the study was to find out the extent to which gender digital divide exists in the Faculty of Education, University of Nairobi. Findings and information presented and discussed in this paper were obtained from a critical review of relevant literature based on gender and digital technology in education. In addition, using documentary analysis guide statistical data based on the number of women and men in selected Information, Communication and Technology courses was derived from the University of Nairobi’s E-Graduation booklets covering three consecutive academic years; 2020, 2021 and 2022. Descriptive data was computed using frequencies and percentages. Findings reveal that gender digital divide gap is clearly visible, for instance, there were only 6 and 8 men and no women graduates in Masters of Science in Computer Science and Masters in Education Technology respectively. Such gender disparity is likely to impact the number of women pursuing Information Communication and Technology-related careers. There is evidence to show that to some extent, the gender digital divide is a result of gendered-related social norms and stereotypes to poor advocacy of digital technological careers. Thus, there is a need to encourage both men and women students to study Information Communication and Technological courses with the aim of ensuring inclusivity and equitable education for everyone, while developing lifelong learning opportunities as stipulated in Sustainable Development Goals 2030
A case report of desmoplastic fibroma in a three-year-old black African girl
Authors: Olaofe Olaejirinde , Okongwu Chigozie , Umerah Godwin , Omoyiola Oluwatosin , Betiku Omolade 
Published: January 2025

Background: Desmoplastic fibroma is a very rare bone tumour that is commonly recognised by its striking resemblance to desmoid fibromatosis, commonly seen in soft tissues.
Case Presentation: A 3-year-old girl presented to the Oral and Maxillofacial Department with swelling on the lower jaw for 4 months duration. Extra-oral examination revealed: Facial asymmetry due to the discrete swelling on the right mandible measuring 14 x 12cm in widest diameter below the right pre-auricular region to the right mental region. The Craniofacial CT scan showed an expansile jaw mass with destruction of the mandible. There was no evidence of bone formation. Histopathology diagnosis was desmoplastic fibroma of the bone. The tumour cells were weakly positive for MyoD1.
Conclusion: Pathologists must know that cells of desmoplastic fibroma may sometimes be weakly positive for MyoD1, as in rhabdomyosarcoma.
High-energy Neutrino Source Cross-correlations with Nearest-neighbor Distributions
Authors: Zhou 周 Zhuoyang 卓扬 , Cisewski-Kehe Jessi , Fang Ke , Banerjee Arka 
Published: January 2025

Abstract
The astrophysical origins of the majority of the IceCube neutrinos remain unknown. Effectively characterizing the spatial distribution of the neutrino samples and associating the events with astrophysical source catalogs can be challenging given the large atmospheric neutrino background and underlying non-Gaussian spatial features in the neutrino and source samples. In this paper, we investigate a framework for identifying and statistically evaluating the cross-correlations between IceCube data and an astrophysical source catalog based on the k-nearest-neighbor cumulative distribution functions (kNN-CDFs). We propose a maximum likelihood estimation procedure for inferring the true proportions of astrophysical neutrinos in the point-source data. We conduct a statistical power analysis of an associated likelihood ratio test with estimations of its sensitivity and discovery potential with synthetic neutrino data samples and a WISE–2MASS galaxy sample. We apply the method to IceCube’s public ten-year point-source data and find no statistically significant evidence for spatial cross-correlations with the selected galaxy sample. We discuss possible extensions to the current method and explore the method’s potential to identify the cross-correlation signals in data sets with different sample sizes.
Magnetic Reconnection between a Solar Jet and a Filament Channel
Authors: Karki Garima , Schmieder Brigitte , Devi Pooja , Chandra Ramesh , Labrosse Nicolas , Joshi Reetika , Gelly Bernard 
Published: January 2025

Abstract
The solar corona is highly structured by bunches of magnetic field lines forming either loops, or twisted flux ropes representing prominences/filaments, or very dynamic structures such as jets. The aim of this paper is to understand the interaction between filament channels and jets. We use high-resolution Hα spectra obtained by the ground-based telescope Télescope Héliographique pour l'Etude du Magnétisme et des Instabilités Solaires on the Canary Islands and data from Helioseismic Magnetic Imager and Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory. In this paper we present a multiwavelength study of the interaction of filaments and jets. They both consist of cool plasma embedded in magnetic structures. A jet is particularly well studied in all the AIA channels with a flow reaching 100–180 km s−1. Its origin is linked to cancelling flux at the edge of the active region. Large Doppler shifts in Hα are derived in a typical area for a short time (order of minute). They correspond to flows around 140 km s−1. In conclusion we conjecture that these flows correspond to some interchange of magnetic field lines between the filament channel and the jets leading to cool plasmoid ejections or reconnection jets perpendicularly to the jet trajectory.
Multiple Episodes of Remote Brightenings Driven by a Coronal Extreme-ultraviolet Jet on the Sun
Authors: Zhang Chao , Huang Zhenghua , Wei Hengyuan , Qi Youqian , Shi Mijie , Fu Hui , Zuo Xiuhui , Liu Weixin , Sun Mingzhe , Xiong Ming , Xia Lidong 
Published: January 2025

Abstract
Remote brightening (RB) is compact brightening at footpoints of magnetic loops, which are remotely connecting to and confining an eruption in the solar atmosphere. Here, we report on observations of an RB resulting from an EUV jet with a speed of about 90 km s−1. The loops connecting the RB and the jet have an apparent length of about 59 Mm. Intriguingly, the RB exhibits at least two episodes of brightenings, as characterized by two peaks in its lightcurve. The energies that sustain the first and second peaks of the RB are 6.3 × 1026 erg and 8.4 × 1026 erg, respectively, and comprise a significant proportion of the total energy. The first peak of the RB brightenings coincides with the jet's peak with a time delay of 12 s, while the second peak lags behind by 108 s. Besides the flows of the ejecta, we have identified two additional flows originating from the eruption site. One is relatively cool with a temperature of

log

10

(
T

/

K

)
=
5.8

–6.1 and a speed of about 275 ± 15 km s−1. The other is hot with a temperature of

log

10

(
T

/

K

)
=
7.0

–7.3 and a much greater speed of about 750 ± 70 km s−1. We attribute the second peak of RB directly to this hot flow, which our numerical experiments suggest is the result of a slow shock wave. Considering the minimal time delay between the first peak of RB and the eruption, we infer that this first episode is due to heating by nonthermal electrons. Our research demonstrates that the dynamics in an RB can offer vital insights into the nature of the corresponding eruption and help understand how energy is distributed throughout the solar atmosphere.
Non-detection of Low-frequency Radio Emission from MTP0015 and MTP044
Authors: Johnson Owen A. , Keane Evan F. , Ashe Charlie K. , McKenna David J. 
Published: January 2025

Abstract
The Irish LOFAR station was used to search for 110–190 MHz radio emission from two recently reported radio transients: MTP0015 and MTP0044. Periodic and single-pulse searches resulted in non-detections; here we report the derived limits.