bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress response and safety of lidocaine combined with dexmedetomidine in patients undergoing laparoscopic hysterectomy
Authors: Zhang Jiao , Chen Jun 
Published: February 2024

Purpose: To investigate the anesthetic effect and safety issues when lidocaine is combined with dexmedetomidine in laparoscopic hysterectomy.
Methods: The data for 100 patients from the Anesthesiology Department of Changzhou Second People's Hospital Affiliated to Nanjing Medical University who underwent laparoscopic total hysterectomy were randomly but equally divided into a control group and a combination group. Lidocaine hydrochloride was administered by infusion in the control group, while dexmedetomidine and lidocaine were administered together in the combination group. Inflammatory factors and stress hormone levels before and after the operation, as well as the incidence of adverse reactions following the operation, hemodynamic index, visual pain simulation (VAS) score, and sedation score at various times after the operation were evaluated in the two groups. Furthermore, the incidence of postoperative adverse reactions were also recorded and compared between the two groups.
Results: The combination group's recovery time was significantly longer than that of the control group (p < 0.05). At the point of extubation and 10 min after, mean arterial pressure (MAP) and heart rate (HR) in the combination group were significantly lower than those of the control group, respectively (p < 0.05), while the combination group's VAS and Ramsay scores were statistically lower than those of the control group at 30 min, 24 h, and 48 h following surgery, respectively (p < 0.05). The incidence of nausea and vomiting in the combination group was significantly lower than that in the control group (28.0% vs 58.0%, p < 0.05).
Conclusion: Lidocaine and dexmedetomidine, when combined, enhance hemodynamics, postoperative analgesia, and sedation in laparoscopic hysterectomy patients. The combination also lowers inflammatory stress and stress hormone levels, as well as the risk of nausea and vomiting, leading to better safety in the patients. However, multicenter trials are recommended to validate these findings prior to its use clinical practice.
Investigation of the efficacy of beta-blockers and reninangiotensin-aldosterone system inhibitors in chronic heart failure with preserved ejection fraction
Authors: Zhao Di , Bu Yanling , Guo Jiarui , Huo Yanping , Zhang Na , Shao Haifeng 
Published: February 2024

Purpose: To investigate the clinical effectiveness of beta-blockers (BBs) and renin-angiotensinaldosterone system (RAAS) inhibitors in chronic heart failure with preserved ejection fraction (HFpEF).
Methods: 100 patients with HFpEF admitted to The Third Affiliated Hospital of Qiqihar Medical University, China, between April and June 2023 were stratified into five groups. Beta-blocker (BB) group received bisoprolol, angiotensin-converting enzyme inhibitor (ACEI) group received benazepril hydrochloride, angiotensin II receptor blocker (ARB) group received candesartan, angiotensin receptor neprilysin inhibitor (ARNI) group received sacubitril valsartan, and mineralocorticoid receptor antagonist (MRA) group received spironolactone. Differences in clinical effectiveness, six-minute walking distance (6MWD), cardiac functionality, quality of life, and survival rate were compared among the groups.
Results: Beta-blocker group showed the highest efficacy. After treatment, all groups except MRA showed significant improvement in 6MWD. Also, ACEI, ARB, and ARNI groups exhibited significantly longer 6 MWD than MRA group (p < 0.05). Left ventricular ejection fraction levels showed significant improvement in the ACEI, ARNI, and MRA groups (p < 0.05), while pulmonary artery pressure (PAP) decreased in the BB, ACEI, ARNI, and MRA groups (p < 0.05). After treatment, the Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores of BB, ACEI, ARB, and ARNI groups were significantly lower than before treatment (p < 0.05). All five groups significantly exhibited decline in NTproBNP levels after treatment (p < 0.05). However, at 18-month follow-up, there was no significant difference in survival rates among the groups (p > 0.05).
Conclusion: Beta-blockers (BBs) and RAAS inhibitors show promising activity in HFpEF, bisoprolol enhances cardiac function, benazepril improves symptoms, candesartan aids exercise and sacubitril valsartan elevates cardiac class. However, none of these drugs significantly improves clinical outcomes.
Impact of nutritional intervention on concurrent chemoradiotherapy outcomes in locally advanced esophageal cancer: A pharmacological perspective
Authors: Liu Jie , Lu Hong , Wang Pei , Zhao Yuexin , Gu Xin , Zuo Yaqin , Yu Dahai 
Published: February 2024

Purpose: To determine the pharmacological implications of nutritional intervention and the occurrence of toxic side effects in patients with locally advanced esophageal cancer undergoing concurrent chemoradiotherapy.
Methods: An extensive retrospective analysis of clinical data was carried out on individuals who received concurrent chemo-radiotherapy. 150 patients were included in the study, with 85 patients receiving nutritional management (intervention group) and 65 patients without nutritional support (control group). Assessments were conducted for Nutritional Risk Screening-2002 (NRS-2002) and patient-generated subjective global assessment (PG- SGA) scores, serum nutritional parameters, toxic side effects and treatment completion rates at 2, 4, and 6 weeks before and during chemo-radiotherapy.
Results: After concurrent chemo-radiotherapy, intervention group exhibited significantly lower NRS2002 and PG- SGA scores compared to control group (p = 0.002 and 0.001, respectively). Intervention group had a statistically significant increase in PALB (p = 0.001) and ALB, while control group experienced a significant decline in ALB (albumin) and PALB (pre-albumin) levels. Grip strength also significantly decreased in control group compared to intervention group (p = 0.003). Intervention group showed a significantly lower incidence of radiation esophagitis. Moreover, a smaller proportion of patients in intervention group experienced interruptions or delays in radiotherapy compared to control group (95 % vs. 83.3 %).
Conclusion: Nutritional intervention has a pharmacological impact on maintaining nutritional status, reducing treatment toxicities and improving the completion rates of chemo- radiotherapy in patients with locally advanced esophageal cancer. Further investigations and longer-term studies are warranted to shed more light on the potential impact of nutritional interventions on the overall survival rates of these patients
Honokiol inhibits gallbladder cancer proliferation and epithelial mesenchymal transformation by suppressing TMPRSS4-induced PI3K/AKT activation
Authors: Lin Conglin , Wang Congren , Li Mingzhu , Cai Zhibing 
Published: February 2024

Purpose: To determine the role of TMPRSS4 in gallbladder cancer (GBC).
Methods: Quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) and western blotting were used to evaluate the expression of genes, while CCK-8 kit and foci formation assay were used to assess cell growth in GBC-SD and non-obliterative zone (NOZ) cell lines. Cell apoptosis was evaluated by flow cytometry, while cell migration and cell invasion were determined by Transwell assay in GBCSD and NOZ cell lines.
Results: TMPRSS4 was highly expressed in GBC cells, compared to normal cell, HIBEC. Overexpression of TMPRSS4 enhanced cell viability and 2D foci formation in GBC-SD (stratified) and NOZ; however, knockdown of TMPRSS4 reduced cell proliferation and colony formation in the cell lines (p < 0.05). TMPRSS4 deficiency increased cell apoptosis but its reinforced expression decreased cell apoptosis in GBC cell lines (p < 0.05). Moreover, TMPRSS4 positively regulated cell invasion and migration in GBC cells by upregulating TWIST1, vimentin and N- cadherin. TMPRSS4 also regulated the activation of PI3K/AKT signal pathway. Furthermore, honokiol inhibited gallbladder cancer proliferation and migration, and induced cell apoptosis by suppressing TMPRSS4-induced PI3K/AKT activation (p < 0.05).
Conclusion: TMPRSS4 plays an important role in regulating cell growth, apoptosis and metastasis of gallbladder cancer cells (GBC). Thus, TMPRSS4 might be a new biomarker in gallbladder cancer.
Catalpol attenuates EMT by inhibiting Wnt/β-catenin and TGF-β/Smads signaling to alleviate kidney fibrosis
Authors: Gao Hong-yan , Ruan Tao-ren , Xing Mao , Chen Yi , Bai Shu-tong , Liu Jin-kun , Yu Xiao-wen , Feng Jing , Xu Xiao-yu , Wang Qin 
Published: February 2024

Purpose: To determine the anti-fibrosis effect and underlying mechanism of action of catalpol (CAT) in chronic kidney disease (CKD).
Methods: Forty (40) rats were randomly divided into a sham group (10 rats) and a unilateral ureteral obstruction (UUO) model group (30 rats) which was further randomly subdivided into three groups of ten (10) rats each: the UUO model group, UUO + CAT low-dose group, and UUO + CAT high-dose group. HK-2 cells were stimulated with TGF-β1 for in vitro studies. Renal injury and fibrotic lesions were determined by H&E and Masson’s staining. Key proteins of TGF-β/Smads and Wnt/β-catenin signaling pathways involved in epithelial- mesenchymal transition (EMT) were determined by immunohistochemistry, immunofluorescence staining and Western blotting.
Results: Catalpol downregulated the expression of α-SMA (p < 0.05) and upregulated the expression of E-cadherin (p < 0.05) stimulated by TGF-β1 and LiCl in HK-2 cells, which is consistent with the role of DKK1 in vitro. CAT ameliorated renal fibrosis and repressed the expression of key proteins of TGFβ/Smads and Wnt/β-catenin pathways in UUO rats.
Conclusion: Catalpol inhibits EMT and alleviates kidney fibrosis by suppressing the hyperactivation of TGF-β/Smad and Wnt/β-catenin signaling pathways. Therefore, CAT is a promising therapeutic drug for renal fibrosis.
Information needs and sources used by small-scale horticulture farmers in Morogoro urban, Tanzania
Authors: Masele Juma James 
Published: February 2024

While the role of information in improving small-scale horticultural farming in urban areas is widely acknowledged in the literature, its potential cannot be realized unless the information needs that enlighten the stakeholders about the appropriate information sources are known. This is because horticultural farming is an information intensive endeavour and it is full of uncertainties. This study investigated information needs and the sources used by small-scale horticulture farmers in Morogoro Urban in Tanzania. A mixed-method research design was used to collect data from 133 respondents. Questionnaires, observation, and interviews were used in the data collection process. Descriptive analysis was used inanalysing quantitative data, while content analysis was used for qualitative data. The findings of the study show that farmers needed information on sowing/harvesting time, disease and pest control, erosion control, harvest storage, and produce markets. Friends/colleagues ranked as important information sources, followed by extension officers, libraries, Internet, colleagues, cooperatives, Nanenane exhibitions, radio, and newspapers. The challenges faced including the unavailability of extension officers, and long distances to/from libraries were mentioned as significant factors hindering farmers’ use of small-scale horticultural farming information and horticultural development in general. Recommendations have been provided that, equip small-scale horticultural crop farmers with up-to-date knowledge and skills to shape the farmers' thinking, knowledge, and attitude. Such awareness will add value to the information exchanged through interpersonal relationships. Employing more skilled extension officers and the use of modern ICT to improve horticulture farmers’ information access is also recommended.
KNOWLEDGE HIDING TRENDS: SYSTEMATIC LITERATURE REVIEW (SLR)
Authors: Sari Annisa , Suyono Joko 
Published: February 2024

This research was conducted by systematic literature review (SLR) analysis using PRISMA assistance in Watase. The purpose of this study is to answer questions related to the trend of knowledge hiding in the last five years. To find out this, this study uses grounded theory which helps in the development of SLR content analysis. The results obtained are that it can be seen that the knowledge hiding is a topic that is of great interest to researchers for further research. This can also be seen from the increase in knowledge hiding articles every year. This study also shows some recommendations obtained from the limitations of previous studies that can help future researchers in exploring and developing research related to knowledge hiding.
TEACHERS’ CHARACTERISTICS AND ITS IMPACT ON STUDENTS' PROFESSIONAL TRAINING IN THE TEACHERS' TRAINING COLLEGES IN FAKO DIVISION, CAMEROON
Authors: Mbeng Etang Samuel Manyi 
Published: February 2024

The purpose of this study was to examine teachers’ characteristics and their impact on students’ professional training in some teacher training schools in Fako Division, the south west region of Cameroon. This study employed a descriptive survey research design with a target population of 100 teachers in two teachers’ training colleges as respondents. Three research objectives were formulated for that purpose which was later transformed into research questions. Data was gathered through the use of questionnaires and was analyzed using Statistical Package for the Social Sciences. The findings reveal there was a positive relationship between teachers’ content mastery, communication, motivation, and personality on student’s professional training. Thus, based on the findings the following recommendations were made; teachers should communicate instructions in simple and clear language so that students will be able to understand also government should constantly organize seminars that will enable teachers to upgrade their knowledge, learn new skills, and become productive.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0214/a.php" alt="Hit counter" /></p>
AN INVESTIGATION OF PRIMARY SCHOOL STUDENTS’ SCIENTIFIC LITERACY
Authors: Tsoumanis Konstantinos G. , Stylos Georgios , Kotsis Konstantinos T. 
Published: February 2024

<p>Scientific literacy (SL) is critical for individuals to cope effectively with the everyday life situations of modern society. On this premise, this survey aims threefold: to validate the Greek version of the SL Assessment (SLA) tool, examine the SL of 425 Greek primary school students, and understand their attitudes and beliefs about science. Reliability and validity were investigated through statistical techniques, including exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and the alpha-Cronbach coefficient. According to the statistical analyses, students have moderate to low SL levels. Variables such as gender and urban vs. rural setting appear to significantly impact the performance of the study’s participants, and of particular interest are students’ attitudes and beliefs about science. The research findings enhance concern over students' low SL level and the extent to which the school establishment responds to society’s science needs and expectations.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/lit/0758/a.php" alt="Hit counter" /></p>
SOFT SKILLS TEACHING AND LEARNING IN MOROCCO: A META ANALYSIS
Authors: Elouaali Soukaina , Hdouch Youcef , Chana Si Mohamed 
Published: February 2024

Soft skills have become a debatable topic, and they have become one of the requirements of the workplace, especially in the era of globalization. That is to say, university graduates, for instance, need to master various soft skills before applying for a job such as communication, cooperation, leadership, and problem-solving, to mention a few. Hence, it is important to integrate and incorporate soft skills in the educational curriculum in order to enable the young generation to join the labor market. Regarding the importance of these skills, this meta-analysis is conducted to explore the situation of soft skills teaching and learning in Morocco. It is based on nine studies on soft skills teaching and learning in Morocco. The analysis supports the importance of soft skills’ inclusion in the Moroccan curriculum; the analyzed articles highly recommend role-play, problem-solving, task-based learning, and debates as effective teaching techniques for soft skills enhancement.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/lit/0758/a.php" alt="Hit counter" /></p>
Insuficiencia suprarrenal aguda secundaria a hemorragia adrenal espontánea por síndrome antifosfolipídico: serie de casos
Authors: Benzaquén Nadia , Riera Julia , Giménez Sebastián , Castro Maximiliano 
Published: February 2024

En la insuficiencia suprarrenal (ISR) la destrucción progresiva del tejido adrenal conduce a la disminución de la secreción de corticoides suprarrenales de forma tal que, una vez instalada, el cuadro clínico reviste gravedad y, sin tratamiento, una elevada mortalidad. El síndrome antifosfolipídico (SAF) es una rara causa de la ISR. En virtud de esto y de la escasez de la literatura disponible se presentan dos casos de ISR asociada a SAF en un sanatorio privado de la ciudad de Santa Fe.
Ambos se caracterizaron por ser del sexo femenino, tener diagnóstico previo de SAF y no presentar otros sitios de trombosis al momento de la consulta. La presentación como hemorragia suprarrenal y estar previamente en tratamiento anticoagulante constituyeron un desafío diagnóstico.
Si bien la ISR es una enfermedad infrecuente, y más aún los casos asociados a SAF, la gravedad de la patología, así como la rapidez de su instalación, ameritan tener una elevada sospecha clínica cuando el cuadro sindrómico es orientador.
Peran Guru Kelas Dalam Menumbuhkan Karakter Religius Siswa Sekolah Dasar Melalui Program Keagamaan
Authors: Rahmawati Rizka , Supriyadi Supriyadi 
Published: February 2024

The research objectives to be achieved are to describe the role of the classroom teacher in cultivating the religious character of elementary school students through religious programs and to describe what factors support and hinder the implementation of religious programs in cultivating religious character at Muhammadiyah 1 Krian Elementary School. is a qualitative descriptive method. The subjects in this study were Class V teachers as well (Heads of Islamic affairs). Methods of data collection using the method of observation, interviews, and documentation. The data analysis technique uses interactive analysis with data reduction, data presentation, and conclusion drawing steps. The results of the study show that the role of the classroom teacher in cultivating the religious character of students through religious programs includes the role of the teacher educating students to get used to reading the Koran for 1 hour before learning takes place. Second, the teacher sets an example in carrying out Duha, Dhuhr and Asr prayers in congregation at school. Third, the teacher guides in carrying out the memorization of the Qur'an. The supporting factors in cultivating students' religious character include support from parents, commitment with school members, and adequate facilities. While the inhibiting factors include different student backgrounds, lack of student awareness, and student environment or association.
Keywords: Teacher's Role, Religious Character, Religious Program
Dampak Pendidikan Multikultural Diberikan kepada Siswa Dalam Meningkatkan Rasa Nasionalisme dan Sikap Toleransi Atas Perbedaan di Lingkungan Sekolah:
Authors: Daulay Nadia Saputri , Siahaan Parlaungan Gabriel , Purba Novridah Reanti , Siagian Nancy Octavia , Betsya Della , Damayanti Putri , Clever Desswan 
Published: February 2024

This examination expects to decide the effect of multicultural training given to understudies in expanding a feeling of patriotism and a mentality of capacity to bear contrasts in the school climate. For this situation, schools need to do exchange by putting each current social development on fair terms. Second, schools need to foster resilience to give chances to each culture to see one another. The examination utilized by the creator is subjective exploration, where the exploration is completed in a smaller however more top to bottom extension. To carry out this, the job of instructors is extremely fundamental since they can assist with imparting life esteems so they can frame characters that reflect public personality. In this examination we incorporated a few respondents comprising of Pancasila Training subject educators, direction and guiding educators and understudies of Medan 27 State Center School in class IX-5. The outcomes we got were that at SMP Negeri 27 MEDAN in class IX-5, 89% of understudies and educators were carrying out multicultural training and practically all understudies and instructors had a feeling of patriotism and a demeanor of capacity to bear contrasts in the school climate. Despite the fact that there were still A few understudies have not taken on a mentality of resilience and a feeling of patriotism in the school climate. So a few arrangements are expected to work on multicultural training in study hall learning.
Watchwords: Resilience, Multicultural Instruction, School
The role of migration processes in the economic development of Russia
Authors: Газизова Т.Р. , Стратиевская Е.С. 
Published: February 2024

В статье рассмотрена роль миграционных процессов в развитии экономики России в связи с актуальными политическими и социальными событиями страны и мира. Было выявлено, что мигранты вносят значительный вклад в экономику страны, увеличивая производительность труда и стимулируя экономический рост. Экономическое положение русских мигрантов в других странах имеет важное значение для экономики России, поскольку они отправляют значительную часть своих заработков в Россию, что способствует укреплению рубля. Авторы отмечают необходимость обеспечения более благоприятных условий для трудовой миграции в России, которые будут способствовать привлечению высококвалифицированных специалистов и укреплению экономической позиции страны в мировом сообществе. Поднимается вопрос важности учета уровня миграции для экономики России и необходимости разработки эффективной миграционной политики.
The article examines the role of migration processes in the development of the Russian economy in connection with current political and social events in the country and the world. It was revealed that migrants make a significant contribution to the country’s economy, increasing labor productivity and stimulating economic growth. The economic situation of Russian migrants in other countries is important for the Russian economy, as they send a significant part of their earnings to Russia, which contributes to the strengthening of the ruble. The authors note the need to ensure more favorable conditions for labor migration in Russia, which will help attract highly qualified specialists and strengthen the country’s economic position in the world community. The issue of the importance of taking into account the level of migration for the Russian economy and the need to develop an effective migration policy is raised.