bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oviposition Dynamics and Niche Utilization in Two Sympatric Drosophila Species
Authors: Moreira-Soto Rolando D. , Hansson Bill S. , Knaden Markus 
Published: February 2025

Abstract
Many Drosophila species coexist by sharing their feeding and breeding sites, which may influence their oviposition choices in an interspecies social context. Whether and where to lay eggs is a crucial decision for female flies as it influences the success of their offspring, by minimizing the risk of predation, competition, or cannibalism. Significant gaps exist in our understanding of Drosophila oviposition dynamics in co-occurring species. Here we tested oviposition strategies of Drosophila melanogaster and its close relative Drosophila simulans under different conditions, to assess whether a single female would prefer to oviposit separately or together with another female, be it a conspecific or not. We find that ovipositing females, regardless whether they are conspecifics or not, prefer to oviposit at the same site. This might suggest that the flies regard the benefits of sharing oviposition sites as higher than the potential risks of competition or cannibalism. The willingness to share oviposition sites was lower when the nutritional value of the medium was increased by adding yeast, and was lost when flies were allowed to lay the eggs consecutively, instead of being tested together. The latter might be explained by our additional finding that females become attracted by the presence of other females on oviposition substrates and that this attraction is partly driven by visual cues. Ovipositing in groups might facilitate intra- and interspecific social feeding of same age offspring, as well as enrichment of microbes. However, this cooperation dynamic might change if another female’s offspring is already present, as it might be perceived as danger of competition or cannibalism.
Dynamic responses of a vibro-impact capsule robot self-propelling in the large intestine via multibody dynamics
Authors: Wang Zepeng , Tian Jiyuan , Liu Yang , Neves Ana , Prasad Shyam 
Published: February 2025

Abstract
In recent years, colonic capsule endoscopy has become available in clinical practice as an alternative modality to colonoscopy. However, it faces challenges such as prolonged examination time and the absence of clinician navigation. Leveraging their pioneering work in the field of vibro-impact self-propulsion technique for gastrointestinal endoscopy, Zhang et al. (IEEE Robot. Autom. Lett. 8:1842–1849, 2023) developed a novel, untethered, self-propelled, endoscopic capsule robot, with the aim of providing a new means of examining bowel cancer in real time. To evaluate and optimize the passage of this capsule robot self-propelling in the large intestine, this work adopts multibody dynamics analysis and experimental investigation to study the robot’s dynamics and its interaction with the intestinal environment. Considering the complex anatomy of the large intestine, containing different sections, e.g., cecum, ascending, transverse, descending, and sigmoid colon, and variations of the haustra, e.g., with various radii, lengths, and heights, the robot was driven by the square-wave excitation of an inner mass interacting with the capsule body and tested on a real porcine colon. The robot’s driving parameters, including the excitation frequency, amplitude, and duty cycle, and the dimensions of the haustra are the two main factors influencing the robot’s progression in the intestine. By comparing with the experimental results, the proposed multibody dynamics model developed using MSC Adams can estimate the movement of the capsule robot and the intestinal resistance quantitatively. Extensive numerical and experimental studies suggest an excitation frequency of 60 Hz and a duty cycle of 0.4 as the optimal parameters for driving the robot, and the longer the haustral length is, the faster the robot passes through. These results ensure the validity of the proposed multibody dynamics platform, which can be used by robotic engineers for developing medical robots for intestinal examinations.
Sonodynamic therapy with a single neoadjuvant, diffuse delivery of low-intensity ultrasound with 5-ALA in treatment naïve glioblastoma results in tumor-specific cytotoxic edema and increased apoptosis
Authors: Stummer Walter , Gerwing Mirjam , Bilgin Sabriye Sennur , Thomas Christian , Villanueva-Meyer Javier , Agarwal Vijay , Stögbauer Louise , Schroeteler Juliane , Müther Michael 
Published: February 2025

Abstract

Purpose
Sonodynamic therapy, which combines a tumor cell-selective sonosensitizer with ultrasound, is gaining attention as a promising new treatment approach for glioblastoma. The objective of this case study is to report on the first applications of 5-aminolevulinic acid (5-ALA) in combination with low-intensity, non-targeted ultrasound as neo-adjuvant treatment in therapy naïve glioblastoma.

Methods
Three patients with therapy naïve newly diagnosed glioblastoma were treated once before cytoreductive surgery with 5-ALA in combination with hemispheric, low-intensity, non-targeted ultrasound, assuming cell death to be triggered by non-ablative activation of 5-ALA-induced, tumor selective porphyrins.

Results
No adverse effects were noted. Post-procedural MRI indicated a decrease in apparent diffusion coefficient values in tumors, suggesting cytotoxic effects. Relative cerebral blood volumes and leakage were increased for two patients with available perfusion imaging. Tissue obtained during surgery suggested increased cleaved-caspase III expression, a marker of apoptosis.

Conclusion
We saw an immediate marked imaging response indicating cytotoxic edema and indications of a histopathology response from just a single treatment. Correlation to clinical outcomes and extension of overall survival remains to be seen. A Phase 1 safety study has been submitted for regulatory approval.
Analysis of Density-Dependent Cell Structure of EPP Bead Foams Under Compression
Authors: Koch I. , Preiß G. , Müller-Pabel M. , Grüber B. , Gude M. 
Published: February 2025

Abstract

Background
Closed cell polymer bead foams are widely used in industrial applications due to their extraordinary damping and insulation properties. To understand the structure-property-relations at different deformation states the volumetric structure of polymer walls, cells and beads should be statistically analysed.

Objective
The presented work is focused on the statistical analysis of the changing cell structure of expanded polypropylene bead foams of different density at distinct compression states.

Methods
Cylindrical bead foam specimens are scanned by x-ray computed tomography at 3-5 different compression states. The reconstructed volume information is segmented and statistically analysed.

Results
It could be shown that, among others, the cell sphericity and their orientation relative to the plane normal to the loading direction are sensitive parameters to the deformation state. With regard to the material symmetry level, a shift of the isotropic foam to transversal isotropic structure was observed. No sudden, stability related, deformation or failure could be observed.

Conclusions
Good metrics for the deformation analysis of expanded polypropylene bead foams from in-situ computed tomography tests are the cell sphericity and orientation. Compression deformation leads to a gradually change of material symmetry level from isotropy to anisotropy.
Real Emotions for Unreal Fictional Objects: A Brentanean Perspective
Authors: Kroon Frederick William 
Published: February 2025

Abstract
The best-known arguments for the reality of emotions to fictional characters are (on their own) unable to show that appreciators of fiction have genuine emotional attitudes to fictional characters. At best, they point to the need to distinguish fictional emotions as states from fictional emotions as (relational) attitudes. I argue for this position by using an argumentative strategy that parallels one found in Brentano’s reist account of intentional states involving non-existent objects. The conception of emotional states that emerges yields a natural anti-realist conception of the intentional objects of such states and supports the view that we can have genuine emotions for unreal fictional objects. I contrast this view with Tim Crane’s and Mark Sainsbury’s well-known anti-realist views of intentionality.
Who influences family tourism decisions? Incorporating children’s perceptions
Authors: Rojas-de-Gracia María-Mercedes 
Published: February 2025

Abstract
This article continues the work of Rojas-de-Gracia et al. (2019) in which they question the appropriateness of relying on a single partner, male or female, to identify the decision-maker in tourism decisions. That study concluded that there is no general consensus among the members of the couple. As a solution, they proposed including the child as an impartial observer. This research tests that suggestion and shows that children’s perceptions differ from those of their parents, considering tourism decisions mostly autonomous and mainly dominated by the mother, contrary to parents’ perceptions of joint decision making. The practical implications of this finding are discussed.
Differential Risk Factors for Hematoma Expansion in Deep and Lobar Intracerebral Hemorrhage
Authors: Zhang Kangwei , Yang Baoqing , Wei Lai , Zhou Xiang , Han Fushi , Meng Jinxi , Zhao Xingyu , Zhang Bo , Chen Daxiao , Wang Peijun 
Published: February 2025

Abstract

Background
Understanding the risk factors for hematoma expansion (HE) in different regions of intracerebral hemorrhage (ICH) can help in the development of more accurate HE prediction tools and in implementing more effective clinical treatment interventions. This study aims to investigate the risk factors for HE in patients with lobar and deep ICH.

Methods
A retrospective analysis was conducted on 558 cases of primary supratentorial ICH from Tongji Hospital Affiliated to Tongji University. Patients were categorized into lobar ICH and deep ICH groups. Differential analysis of ICH characteristics at different locations was performed, followed by subgroup analysis based on HE occurrence. Binary logistic regression was used to identify independent risk factors for HE in each group.

Results
Among the 404 patients with ICH who underwent follow-up noncontrast computed tomography (NCCT) scans, the proportion with HE was similar in the deep ICH group (23.2%) and the lobar ICH group (22.7%). Binary logistic regression analysis revealed that fluid level (odds ratio [OR] 4.77, 95% confidence interval [CI] 1.74–13.06), admission Glasgow Coma Scale score (OR 0.87, 95% CI 0.80–0.96), and time from onset to NCCT examination (OR 0.84, 95% CI 0.75–0.94) were independently associated with HE in the deep ICH group. In the lobar ICH group, irregular shape (OR 4.96, 95% CI 1.37–18.01) and fibrinogen level (OR 0.42, 95% CI 0.21–0.86) were significant risk factors.

Conclusions
Fluid level, low admission Glasgow Coma Scale score, and shorter time from onset to NCCT are independent predictors of HE in deep ICH, whereas irregular shape and low fibrinogen levels are independent predictors of HE in lobar ICH. These findings are of great significance for elucidating the mechanisms underlying HE in different locations of ICH and for developing precise predictive models of HE.
How parentification relates to obsessive-compulsive disorder (OCD) and relationship obsessive-compulsive disorder (ROCD): the mediating role of obsessive beliefs
Authors: Trak Ezgi , Acar Sukriye , Inozu Mujgan 
Published: February 2025

Abstract
OCD is characterized by obsessions (intrusive thoughts, images or urges) and compulsions (repetitive behaviors or cognitive acts) to alleviate anxiety caused by the obsessions. Parentification is the phenomenon whereby parents assign adult roles to their children, expecting them to perform practical and emotional tasks. Previous research has linked parentification to both beneficial and detrimental consequences for the child. Despite previous research suggesting that parent-child interactions are a contributor to the development and persistence of obsessive tendencies, research investigating the role of parentification in OCD and the relationship obsessive-compulsive disorder (ROCD) is lacking. This study evaluates the relationship between benefits and negative aspects of parentification, OCD, and ROCD symptoms. In addition, the study examines the mediating role of obsessive beliefs in these associations. A community sample of 788 participants responded to self-report questionnaires of parentification, obsessive beliefs, OCD, and ROCD. Findings revealed that parent and sibling-focused parentification were positively associated with OCD and ROCD symptoms, whereas perceived benefits of parentification were negatively associated with OCD and ROCD. Furthermore, obsessive beliefs mediated the relationship between parentification and obsessive tendencies. Findings suggest that individuals who have undergone parentification may be more susceptible to developing maladaptive beliefs that may subsequently lead to obsessive preoccupation. The study contributes to the clarification of complex interplay between developmental factors such as parentification, cognitive factors such as obsessive beliefs, and obsessive tendencies.
Efficiency criteria and dual models for multi-objective semi-infinite constrained minimization problems with vanishing restrictions
Authors: Roy Murari Kumar , Joshi Bhuwan Chandra , Treanţă Savin , Marghescu Cristina-Florentina 
Published: February 2025

Abstract
This article delves into the analysis of semi-infinite multi-objective optimization problems characterized by constraints that gradually vanish. We establish sufficient efficiency criteria to determine whether a feasible solution attains a Pareto solution in the given multi-objective optimization problem considering the presence of vanishing constraints and suitable generalized convexity assumptions. We provide illustrative examples to confirm the validity of our findings. Additionally, we derive weak, converse, strong converse, and strong duality theorems for a dual model based on Mond–Weir principles, relying on generalized convexity assumptions.
The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction
Authors: Marchette Renata C. N. , Vendruscolo Leandro F. , Koob George F. 
Published: February 2025

Abstract

Purpose of Review
Drug addiction is characterized by compulsive drug seeking and use, accompanied by negative emotional states (hyperkatifeia) and heightened pain sensitivity (hyperalgesia) during withdrawal. Both hyperalgesia and hyperkatifeia are integral components of substance use disorders, negatively impacting treatment and recovery. The underlying neurobiological mechanisms of hyperalgesia and hyperkatifeia involve alterations of brain reward and stress circuits, including the dynorphin/κ-opioid receptor (KOR) system. The dynorphin/KOR system modulates pain perception, negative affect, and addictive behaviors. Here, we review the preclinical evidence of dynorphin/KOR signaling in opioid withdrawal-induced hyperalgesia and hyperkatifeia.

Recent Findings
In opioid dependence models, pharmacological and genetic interventions of the dynorphin/KOR system attenuate somatic and motivational signs of withdrawal and addictive-like behaviors, highlighting its therapeutic potential. Understanding the intricate interplay between dynorphin/KOR signaling, hyperalgesia, hyperkatifeia, and addiction offers novel insights into treatment strategies for opioid use disorder and other substance use disorders.

Summary
Further research is needed to elucidate precise mechanisms of the sexual dimorphism of dynorphin/KOR signaling and identify targeted interventions to mitigate hyperalgesia and hyperkatifeia and facilitate recovery from addiction.
Technology-Based Interventions for the Treatment of Peripartum Depression: An In-Depth Systematic Review
Authors: Aștefanei Andreea , Miclea Mircea 
Published: February 2025

Abstract
Technology-based interventions have the potential to be effective in reducing peripartum depression and to increase the access to treatment. Previous systematic reviews focus on the efficacy of the interventions, giving little attention to the programs themselves. The aims of this review are to provide a comprehensive inventory of the program’s components and structure, to analyze their efficacy, and to offer general guidelines for interventions development. A systematic search was conducted in five databases and reported using PRISMA guidelines. An in-depth synthesis and analysis was performed globally as well as on each intervention program. Eighteen reports were included covering 11 different interventions. Overall, the interventions are effective, leading to medium-large reductions of peripartum depression symptoms. All relevant aspects were analyzed such as the most common components, number of sessions, completion rates, extra features, or screening procedure. Guidelines for program development were formulated based on the analysis, covering elements relevant for increasing efficacy as well as treatment adherence. Aspects regarding content as well as mode of delivery are considered.
Levelling up the Recycling Experience: Gamification of Recycling through an Innovative Recycling Station
Authors: Rosenlund Joacim , Helmefalk Miralem , Stenfelt Sofie , Palmquist Adam 
Published: February 2025

Abstract
This paper aims to explore the relation between gamification and recycling of household waste by answering the question of how a gamified recycling station can make recycling a more engaging experience. The station was designed to make recycling a smart, neat and engaging experience for fifteen households during six months. A smartphone application based on gamification mechanics was developed including missions, achievements, quizzes and a visual progression map. Participants were using the smartphone application providing data during the project, as well as were interviewed before and after the period. Results show that when examining recycling experiences in terms of interaction, knowledge, attitudes, and perception, three different groups of participants could be identified. It was shown that the connection between the physical environment and smartphone application was important to consider as these had to be congruent. Further, it was revealed that such intervention via gamification and a new recycling station could contribute to a better recycling experience and increase knowledge, depending on the type of user ranging from engaged, partly engaged to not engaged.
Mitigating ammonia inhibition in anaerobic digestion with lignin-based carbon materials synthesized by hydrothermal carbonization
Authors: Ma Shuaishuai , Wang Hongliang , Gao Xin , Bian Chuanfei , Zhu Wanbin 
Published: February 2025

Abstract
Ammonia inhibition poses a significant challenge to the efficient and stable operation of anaerobic digestion (AD) systems by leading to the inhibition of volatile fatty acid conversion and reduced methane production. This study explores the utilization of lignin-based hydrochar (LHC) and carbon quantum dots (CQDs) produced via hydrothermal carbonization of alkali lignin to alleviate ammonia inhibition in AD processes. The results showed that both LHC and CQDs help counter the decline in methane yield and production rate typically associated with ammonia inhibition. Notably, the addition of 1 g/L CQDs significantly increased methane production by 24.25% compared to the control group. While LHC showed limited ammonia adsorption, its primary impact was enhancing direct interspecies electron transfer (DIET) through improved redox capacity and promoting humic acid-like organics formation. In contrast, CQDs reduced charge transfer resistance, significantly enhancing system redox capacity. Optimizing the hydrothermal carbonization temperature of LHC to 250 °C further optimized its redox properties, boosting methane production by 30.53% at a concentration of 3 g/L. Microbial community and metabolic pathway analyses indicated that LHC and CQDs enriched hydrolytic and acidifying bacteria, as well as DIET-associated microorganisms, facilitating efficient volatile fatty acid production and conversion. This process enabled the sustained operation of both acetoclastic and hydrogenotrophic methanogenic pathways, effectively mitigating the adverse effects of high ammonia nitrogen concentrations.

Graphical Abstract
Does being financially resilient lead to better economic outcomes?
Authors: Clark Robert L. , Lusardi Annamaria , Mitchell Olivia S. 
Published: February 2025

Abstract
Some Americans prepare for unanticipated adverse economic events, plan for the future, and keep their debt at manageable levels, but others do not. Using four waves of the Understanding America Study during the pandemic period, we compare middle-aged and older Black, Hispanic, and White Americans’ financial resilience from 2020 to 2024. After uncovering significant initial differences in their financial preparedness at the outset of the pandemic, we confirm that greater financial resilience enhanced peoples’ chances of realizing better economic outcomes when confronting adverse economic shocks. The 2024 wave shows systematic differences in financial resilience across the demographic groups and indicates how greater resilience affects financial satisfaction.
Lifetime and past-year suicidal behaviors among adolescents in Bangladesh: A two-stage stratified cluster sampling study
Authors: Al-Mamun Firoj , Al Habib Abdullah , Islam Johurul , ALmerab Moneerah Mohammad , Mamun Mohammed A. , Muhit Mohammad 
Published: February 2025

Abstract
Adolescence is a critical period marked by significant physical and psychological changes, yet there is limited understanding of suicidal behaviors among adolescents in Bangladesh. To address this gap, the MeLiSA study utilizing a two-stage stratified cluster sampling approach was conducted to investigate the prevalence and associated factors of suicidal ideation, plans and attempts among adolescents. A total of 1,496 participants were recruited from urban and rural areas, and their socio-demographic characteristics and data on smoking, alcohol use, depression, anxiety and insomnia were obtained. Chi-square and Fisher’s exact tests were used for univariate analyses, followed by multivariable logistic regression to identify factors associated with suicidal behaviors. The findings revealed that 6.8% reported experiencing lifetime suicidal ideation, with 2.3% suicide plans and 0.8% suicide attempts. The 12-month prevalence rates were 3.2% for suicidal ideation, 1.5% for suicide plans and 0.6% for suicide attempts. Smoking emerged as a significant predictor of suicidal ideation, plans and attempts, while alcohol use was strongly linked to past-year suicide attempts. Depression was associated with lifetime suicidal ideation, whereas anxiety significantly influenced both lifetime and past-year suicide plans. These results provide valuable insights that could inform evidence-based interventions and policies to address prevalent mental disorders and suicidal behaviors among adolescents in Bangladesh.