bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exosomes as Theranostic Agents in Reproduction System
Authors: Izadpanah Melika , Yalameha Banafsheh , Sani Maryam Zamani , Cheragh Parisa Khani , Mahdipour Mahdi , Rezabakhsh Aysa , Rahbarghazi Reza 
Published: November 2023

AbstractExosomes (Exos), belonging to extracellular vesicles, are cell‐derived nano‐sized vesicles with the potential to carry different kinds of biological molecules. Many studies have proved the impacts of exosomal cargo on several biological processes in female and male reproductive systems. It is also hypothesized that changes in exosomal cargo are integral to the promotion of certain pathological conditions, thus Exos can be used as valid biomarkers for the diagnosis of infertility and other abnormal conditions. Here, efforts are made to collect some recent data related to the physiological significance of Exos in the reproductive system, and their potential therapeutic effects. It is anticipated that the current review article will lay the groundwork for elucidating the source and mechanisms by which Exos control the reproductive system additionally supplying fresh methods and concepts for the detection and treatment of disorders associated with fertility for future studies.
Comprehensive Matrisome Profiling of Human Adipose Tissue for Soft Tissue Reconstruction
Authors: Major Gretel , Simcock Jeremy , Kumar Abhishek , Kleffmann Torsten , Woodfield Tim B. F. , Lim Khoon S. 
Published: November 2023

AbstractFor effective translation of research from tissue engineering and regenerative medicine domains, the cell‐instructive extracellular matrix (ECM) of specific tissues must be accurately realized. As adipose tissue is gaining traction as a biomaterial for soft tissue reconstruction, with highly variable clinical outcomes obtained, a quantitative investigation of the adipose tissue matrisome is overdue. In this study, the human adipose tissue matrisome is profiled using quantitative sequential windowed acquisition of all theoretical fragment ion spectra ‐ mass spectrometry (SWATH‐MS) proteomics across a cohort of 13 fat‐grafting patients, to provide characterization of ECM proteins within the tissue, and to understand human population variation. There are considerable differences in the expression of matrisome proteins across the patient cohort, with age and lipoaspirate collection technique contributing to the greatest variation across the core matrisome. A high abundance of basement membrane proteins (collagen IV and heparan sulfate proteoglycan) is detected, as well as fibrillar collagens I and II, reflecting the hierarchical structure of the tissue. This study provides a comprehensive proteomic evaluation of the adipose tissue matrisome and contributes to an enhanced understanding of the influence of the matrisome in adipose‐related pathologies by providing a healthy reference cohort and details an experimental pipeline that can be further exploited for future biomaterial development.
Hydrodynamic Assembly of Astrocyte Cells in Conductive Hollow Microfibers
Authors: Ouedraogo Lionel J. , Trznadel Mychal J. , Kling McKayla , Nasirian Vahid , Borst Alexandra G. , Shirsavar Mehran Abbasi , Makowski Andrew , McNamara Marilyn C. , Montazami Reza , Hashemi Nicole N. 
Published: November 2023

AbstractThe manufacturing of 3D cell scaffoldings provides advantages for modeling diseases and injuries as it enables the creation of physiologically relevant platforms. A triple‐flow microfluidic device is developed to rapidly fabricate alginate/graphene hollow microfibers based on the gelation of alginate induced with CaCl2. This five‐channel microdevice actualizes continuous mild fabrication of hollow fibers under an optimized flow rate ratio of 300:200:100 µL min−1. The polymer solution is 2.5% alginate in 0.1% graphene and a 30% polyethylene glycol solution is used as the sheath and core solutions. The biocompatibility of these conductive microfibers by encapsulating mouse astrocyte cells (C8D1A) within the scaffolds is investigated. The cells can successfully survive both the manufacturing process and prolonged encapsulation for up to 8 days, where there is between 18–53% of live cells on both the alginate microfibers and alginate/graphene microfibers. These unique 3D hollow scaffolds can significantly enhance the available surface area for nutrient transport to the cells. In addition, these conductive hollow scaffolds illustrate unique advantages such as 0.728 cm3 gr−1 porosity and two times more electrical conductivity in comparison to alginate scaffolds. The results confirm the potential of these scaffolds as a microenvironment that supports cell growth.
Impact of a Short‐Pulse High‐Intense Proton Irradiation on High‐Performance Perovskite Solar Cells
Authors: Parkhomenko Hryhorii P. , Solovan Mykhailo M. , Sahare Sanjay , Mostovyi Andriy I. , Aidarkhanov Damir , Schopp Nora , Kovaliuk Taras , Kaikanov Marat , Ng Annie , Brus Viktor V. 
Published: November 2023

AbstractThis work investigates the radiation resistance of high‐performance multi‐component perovskite solar cells (PSCs) for the first time under extreme short‐pulse proton irradiation conditions. The devices are subjected to high‐intensity 170 keV pulsed (150 ns) proton irradiation, with a fluence of up to 1013 p cm−2, corresponding to ≈30 years of operation at low Earth orbit. A complex material characterization of the perovskite active layer and device physics analysis of the PSCs before and after short‐pulse proton irradiation is conducted. The obtained results indicate that the photovoltaic performance of the solar cells experiences a slight deterioration up to 20 % and 50 % following the low 2 × 1012 p cm−2 and high 1 × 1013 p cm−2 proton fluences, respectively, due to increased non‐radiative recombination losses. The findings reveal that multi‐component PSCs are immune even to extreme high‐intense short‐pulse proton irradiation, which exceeds harsh space conditions, including intense coronal ejection events usually associated with solar flares.
Biomimetic Metal–Organic Framework Combats Biofilm‐Associated Infections via Hyperthermia‐Enhanced Bacterial Metabolic Interference and Autophagy‐Promoted Adaptive Immunity
Authors: Hu Xianli , Ma Ruixiang , Zhang Peng , Dong Jiale , Sun Jiaxuan , Wang Wenzhi , Liu Quan , Kong Lingtong , Zhang Xudong , Wang Zhengxi , Mei Jiawei , Shang Xifu , Zhu Wanbo , Su Zheng , Zhu Chen 
Published: November 2023

AbstractRobust bacterial metabolism and the immunosuppression on peripheral immune cells cause biofilm‐associated infections (BAIs) extremely refractory to be eradicated via antibiotics alone. Herein, hierarchical mesoporous UiO‐66 metal–organic framework is decorated with selenite, polypyrrole, and macrophage membrane (MM) to develop a biomimetic nanosphere (USPM). Following the recruitment of USPM to the biofilm microenvironment (BME) via the pathogen‐targeting ability derived from MM. The BME‐responsive USPM can precisely release selenite to penetrate the loosened biofilm in synergy with near‐infrared‐induced mild photothermal therapy (mPTT). Selenite can quickly react with reducing substances to generate hydrogen selenide (H2Se) inside the biofilm. H2Se can competitively inhibit bacterial metabolic processes and disrupt biofilm metabolic homeostasis by cascade amplification effects. Furthermore, H2Se inside the biofilm further sensitizes photothermia to exert a precise local photothermal effect. Outside the biofilm, USPM can simultaneously promote the phagocytosis and autophagy of macrophages to kill and decompose the phagocytosed bacteria. Finally, the well‐decomposed bacterial antigens in macrophages can be presented to antigen‐presenting cells to arouse adaptive immune responses and enhance anti‐biofilm effectiveness further. Such powerful mPTT‐enhanced bacterial metabolic disruption and macrophagic autophagy‐promoted adaptive immune activation suggest an alternative therapeutic strategy to cure refractory BAIs.
Novel Dibenzofulvene‐Based NIR‐II Emission Phototheranostic Agent with an 82.6% Photothermal Conversion Efficiency for Photothermal Therapy
Authors: Liu Yan‐Zhao , Ran Xiao‐Yun , Zhou Ding‐Heng , Zhang Hong , Chen Yu‐Jin , Xu Ji‐Xuan , Chen Shan‐Yong , Kong Qing‐Quan , Yu Xiao‐Qi , Li Kun 
Published: November 2023

AbstractOrganic molecules with second near‐infrared (NIR‐II, 1000–1700 nm) emission have significant advantages over NIR‐I (600–900 nm) dyes, and have been widely used as phototheranostic agents (PTAs) and fluorescent probes. However, the two biggest challenges for such reagents are improving photothermal conversion efficiency (PCE), and simplifying tedious synthetic procedures. Herein, different from the traditional NIR skeleton, for the first time, it develops two novel dibenzofulvene‐based NIR‐II emission PTAs via D‐π‐A concept with high PCEs through two simple synthetic steps. The increased intramolecular charge transfer effect and extended π‐conjugation effectively red‐shift their emissions to the NIR‐II region. In addition, the introduction of molecular rotors/vibrators and the formation of π–π stacking prompt the two PTAs to exhibit high PCEs. Notably, FE‐IDMN nanoparticles (FE‐IDMN NPs) achieve an exciting PCE of 82.6%, higher than most reported photothermal agents with NIR‐II emission. FE‐IDMN NPs also possess good colloidal, pH, and photothermal stabilities, as well as excellent photoacoustic response, which is further successfully applied for NIR‐II fluorescence/photoacoustic/photothermal imaging‐guided photothermal therapy. This work provides a simple strategy for constructing new D‐π‐A PTAs with low molecular weight, NIR‐II emission, and high PCE for cancer therapy.
Hydrogel‐Embedded Precision‐Cut Lung Slices Model Lung Cancer Premalignancy Ex Vivo
Authors: Blomberg Rachel , Sompel Kayla , Hauer Caroline , Smith Alex J. , Peña Brisa , Driscoll Jennifer , Hume Patrick S. , Merrick Daniel T. , Tennis Meredith A. , Magin Chelsea M. 
Published: November 2023

AbstractLung cancer is the leading global cause of cancer‐related deaths. Although smoking cessation is the best prevention, 50% of lung cancer diagnoses occur in people who have quit smoking. Research into treatment options for high‐risk patients is constrained to rodent models, which are time‐consuming, expensive, and require large cohorts. Embedding precision‐cut lung slices (PCLS) within an engineered hydrogel and exposing this tissue to vinyl carbamate, a carcinogen from cigarette smoke, creates an in vitro model of lung cancer premalignancy. Hydrogel formulations are selected to promote early lung cancer cellular phenotypes and extend PCLS viability to six weeks. Hydrogel‐embedded PCLS are exposed to vinyl carbamate, which induces adenocarcinoma in mice. Analysis of proliferation, gene expression, histology, tissue stiffness, and cellular content after six weeks reveals that vinyl carbamate induces premalignant lesions with a mixed adenoma/squamous phenotype. Putative chemoprevention agents diffuse through the hydrogel and induce tissue‐level changes. The design parameters selected using murine tissue are validated with hydrogel‐embedded human PCLS and results show increased proliferation and premalignant lesion gene expression patterns. This tissue‐engineered model of human lung cancer premalignancy is the foundation for more sophisticated ex vivo models that enable the study of carcinogenesis and chemoprevention strategies.
Post‐Graphene 2D Materials: Structures, Properties, and Cancer Therapy Applications
Authors: Kuang Fei , Hui Tiankun , Chen Yingjie , Qiu Meng , Gao Xiang 
Published: November 2023

AbstractCancer is one of the most serious diseases challenging human health and life span. Cancer has claimed millions of lives worldwide. Early diagnosis and effective treatment of cancer are very important for the survival of patients. In recent years, 2D nanomaterials have shown great potential in the development of anticancer treatment by combining their inherent physicochemical properties after surface modification. 2D nanomaterials have attracted great interest due to their unique nanosheet structure, large surface area, and extraordinary physicochemical properties. This article reviews the advantages and application status of emerging 2D nanomaterials for targeted tumor synergistic therapy compared with traditional therapeutic strategies. In order to investigate novel potential anticancer strategies, this paper focuses on the surface modification, cargo delivery capability, and unique optical properties of emerging 2D nanomaterials. Finally, the current problems and challenges in cancer treatment are summarized and prospected.
Realizing Superior Luminescence in Oxyfluoride Glass‐Ceramics by Enhancing Nano‐Micro Phase Separation
Authors: Li Zhencai , Li Junhao , Chen Chunying , Li Sai , Hu Jie , Christensen Johan F. S. , Zhou Dacheng , Jensen Lars R. , Ni Jiachuan , Qiao Xvsheng , Du Jincheng , Smedskjaer Morten M. , Shinozaki Kenji , Zhang Yanfei , Qiu Jianbei , Ren Jinjun , Yue Yuanzheng 
Published: November 2023

AbstractIn this work, a novel series of oxyfluoride glasses‐ceramics (GCs) is developed by enhancing the phase separation through the substitution of LaF3 for La2O3. The thus‐derived GCs exhibit a remarkable 2700‐fold increase in up‐conversion (UC) luminescence of Er3+ ions compared to the precursor glass. From the 19F Nuclear Magnetic Resonance analysis, this enhancement is attributed to the structural disorder‐to‐order transition in the fluoride‐rich phase. Upon isothermal heat treatment, the translucent GCs transform into transparent ones, making UC luminescence even stronger. The enhanced UC luminescence leads to strong temperature‐sensing ability of the studied glasses. The nano‐micro phase separation is clarified by atomistic simulations and scanning electron microscopy. This study implies that phase separation engineering is a powerful way to achieve superior photonic performances.
Serum Metabolic Fingerprints Characterize Systemic Lupus Erythematosus
Authors: Li Shunxiang , Ding Huihua , Qi Ziheng , Yang Jing , Huang Jingyi , Huang Lin , Zhang Mengji , Tang Yuanjia , Shen Nan , Qian Kun , Guo Qiang , Wan Jingjing 
Published: November 2023

AbstractMetabolic fingerprints in serum characterize diverse diseases for diagnostics and biomarker discovery. The identification of systemic lupus erythematosus (SLE) by serum metabolic fingerprints (SMFs) will facilitate precision medicine in SLE in an early and designed manner. Here, a discovery cohort of 731 individuals including 357 SLE patients and 374 healthy controls (HCs), and a validation cohort of 184 individuals (SLE/HC, 91/93) are constructed. Each SMF is directly recorded by nano‐assisted laser desorption/ionization mass spectrometry (LDI MS) within 1 minute using 1 µL of native serum, which contains 908 mass to charge features. Sparse learning of SMFs achieves the SLE identification with sensitivity/specificity and area‐under‐the‐curve (AUC) up to 86.0%/92.0% and 0.950 for the discovery cohort. For the independent validation cohort, it exhibits no performance loss by affording the sensitivity/specificity and AUC of 89.0%/100.0% and 0.992. Notably, a metabolic biomarker panel is screened out from the SMFs, demonstrating the unique metabolic pattern of SLE patients different from both HCs and rheumatoid arthritis patients. In conclusion, SMFs characterize SLE by revealing its unique metabolic pattern. Different regulation of small molecule metabolites contributes to the precise diagnosis of autoimmune disease and further exploration of the pathogenic mechanisms.
The Interplay Between Ferroelectricity and Electrochemical Reactivity on the Surface of Binary Ferroelectric AlxB1‐xN
Authors: Liu Yongtao , Ievlev Anton , Casamento Joseph , Hayden John , Trolier‐McKinstry Susan , Maria Jon‐Paul , Kalinin Sergei V. , Kelley Kyle P. 
Published: November 2023

AbstractPolarization dynamics and domain structure evolution in ferroelectric Al0.93B0.07N are studied using piezoresponse force microscopy and spectroscopies in ambient and controlled atmosphere environments. The application of negative unipolar and bipolar first‐order reverse curve (FORC) waveforms leads to a protrusion‐like feature on the Al0.93B0.07N surface and a reduction of electromechanical response due to electrochemical reactivity. A surface change is also observed on the application of fast alternating current bias. At the same time, the application of positive biases does not lead to surface changes. Comparatively in a controlled glove box atmosphere, stable polarization patterns can be observed, with minuscule changes in surface morphology. This surface morphology change is not isolated to applying biases to free surface, a similar topographical change is also observed at the electrode edges when cycling a capacitor in an ambient environment. The study suggests that surface electrochemical reactivity may have a significant impact on the functionality of this material in the ambient environment. However, even in the controlled atmosphere, the participation of the surface ions in polarization switching phenomena and ionic compensation is possible.
Built‐In Electric Fields and Interfacial Electron Modulation: Enhancement of Oxygen Reduction Reaction in Alkaline Seawater
Authors: Mao Huimin , Liu Xiaobin , Wu Siqi , Sun Guiru , Zhou Guizhong , Chi Jingqi , Wang Lei 
Published: November 2023

AbstractThe development of an electrocatalyst for oxygen reduction reaction (ORR) in a seawater electrolyte is the key to realizing the utilization of marine resources and application of Zn–air batteries (ZABs). Exploring the adsorption and desorption behavior of oxygen can guide the design of catalysts fundamentally and improve the catalytic performance. On this basis, WC and Co on nitrogen‐doped carbon (WC‐Co@NC) with an interfacial built‐in electric field (BEF) is designed as an ORR catalyst. The theoretical calculation certifies that the BEF of W─C─Co connections promote charge separation and directional migration, thus realizing the oxygen adsorption equilibrium and speeding up the process of ORR. These give WC‐Co@NC a high half‐wave potential of 0.872 V, and the alkaline seawater‐based ZAB with WC‐Co@NC as the air cathode has a peak power density of 188.8 mW cm−2 and excellent stability. This work can provide a basis for the rational design of the cathode of alkaline seawater‐based ZAB, and can also give a new direction for the utilization of seawater resources.
Highly Stable Vertically Oriented 2H‐NbS2 Nanosheets on Carbon Nanotube Films toward Superior Electrocatalytic Activity
Authors: Peng You , Zhu Lijie , Li Chenyu , Hu Jingyi , Lu Yue , Fu Jiatian , Cui Fangfang , Wang Xiangzhuo , Cao Anyuan , Ji Qingqing , Huan Yahuan , Zhang Yanfeng 
Published: November 2023

Abstract2D metallic transition‐metal dichalcogenides (MTMDCs) have attracted widespread research interest in the exploration of fundamental physical issues and energy‐related fields. Although relatively high catalytic activity has been predicted theoretically in the new type MTMDCs‐based electrocatalysts, their hydrogen evolution reaction (HER) performance is severely hampered by the insufficient catalytic stability due to structural degradation during long‐time use and limited active sites in planar electrode structures. Herein, the scalable synthesis of vertically‐oriented 2H‐NbS2 nanosheets is reported on low‐cost carbon nanotube (CNT) film substrates by a facile chemical vapor deposition route. The 3D vertically‐oriented 2H‐NbS2 nanosheets present abundant edge active sites and strong interface coupling with CNT thus possessing exceptional mechanical stability. These features impart the 3D nanosheets catalysts with remarkably low overpotentials of ≈55 mV at 10 mA cm−2 and ultra‐high exchange current density of ≈1445 µA cm−2, and negligible performance degradation after 200 h operation at the large current density, which are superior to those of other TMDCs‐based catalysts. This work hereby provides novel perspectives for the batch synthesis and application of 3D MTMDCs‐based electrocatalysts with greatly improved electrocatalytic performance and stability that are needed for practical applications.
Thin, Highly Ionic Conductive, and Mechanically Robust Frame‐Based Solid Electrolyte Membrane for All‐Solid‐State Li Batteries
Authors: Kim Dohwan , Lee Hyobin , Roh Youngjoon , Lee Jongjun , Song Jihun , Dzakpasu Cyril Bubu , Kang Seok Hun , Choi Jaecheol , Kim Dong Hyeon , Hah Hoe Jin , Cho Kuk Young , Lee Young‐Gi , Lee Yong Min 
Published: November 2023

AbstractA thin but robust solid electrolyte layer is crucial for realizing the theoretical energy density of all‐solid‐state batteries (ASSBs) beyond state‐of‐the‐art Li‐ion batteries (LIBs). This study proposes a simple but practical strategy for fabricating thin solid electrolyte membranes using 5‐µm perforated polyethylene separators with 35% open areas as the supporting component, which ensures mechanical robustness for commercial‐level cell assembly. The thickness of this frame‐based solid electrolyte (f‐SE) membrane can be reduced to ≈45 µm, even after coating the Li6PS5Cl (LPSCl) solid electrolyte composite. Despite a slightly lower ionic conductivity compared to that of thick LPSCl pellets, the f‐SE membranes show high conductance and low overpotential in Li||Li symmetric cells. Their incorporation into LiNi0.7Co0.15Mn0.15O2 full cells increases the reversible capacity and rate capability compared to those of cells with conventional LPSCl pellets. The f‐SE membrane cells exhibit excellent cycling stability over 250 cycles, while maintaining high‐capacity retention and Coulombic efficiency. Notably, the f‐SE membranes significantly increase the energy density of ASSBs (314 Wh kg−1), exceeding the values reported for sulfide‐based cells. These results highlight the crucial role of f‐SE membranes in improving the mechanical properties and energy density of ASSBs, thereby contributing to the development of next‐generation Li battery technologies.
Hydrodynamics and model of gas‐liquid flow in microbubble column reactors
Authors: Xie Bingqi , Liu Wei , Jiang Yifan , Chen Junxin , Zhou Caijin , Zhang Jisong 
Published: November 2023

AbstractMicrobubble column reactors (MBCRs) have the significant advantages of high gas holdup, large gas‐liquid interfacial area, and excellent mass transfer performance, making them attractive for applications such as hydrogenation and oxidation. However, there is still a lack of comprehensive understanding of the gas‐liquid flow behavior in MBCRs. In this work, the effects of gas and liquid superficial velocities on flow regimes, residence time distribution, and gas holdup are investigated. The gas holdup increases linearly with the increase of gas superficial velocity, even in heterogeneous regimes, ranging from 0% to 60% at gas superficial velocities of 0–25 mm/s. Additionally, the gas‐liquid interfacial areas in MBCRs are 1–2 orders of magnitude larger than those in traditional bubble column reactors. A prediction model for gas holdup is established, and the predicted values are in good agreement with the experimental values.