bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-adjusted Three-Dimensional Plate Employing Printing versus Conventional Plate in the Management of Mandibular Fractures - A Comparative Study
Authors: Kende Prajwalit P. , Sarda Ashish Sunilkumar , Landge Jayant , Wadewale Maroti , Kri Mrimingsi , Ranganath Suleka 
Published: December 2023

Abstract

Introduction:
The aim of this study was to compare the efficacy of pre-adjusted three-dimensional (3D) plating system employing 3D printing with conventional 3D plating in the management of mandibular fractures.

Materials and Methods:
A randomised, clinical trial was conducted where the study sample (n = 20) was divided into two groups. In Group 1, 3D plate and in Group 2, pre-bent 3D plate was fixed to the fracture site. The parameters assessed were number of bends required for adaptation, duration of fixation, pain, occlusal stability, reduction in lingual splaying and post-operative complications.

Results:
Statistically significant difference was seen for the number of bends required (P = 0.000, P < 0.01) and duration of fracture fixation (P = 0.001, P < 0.01). There was statistically significant difference between the values of pain during the adaptation of 3D plate (P = 0.033, P < 0.05).

Discussion:
The application of pre-adjusted 3D plate is superior to conventional 3D plating in terms of reducing number of bends, duration of fixation and pain during adaptation.
Robot-assisted Surgery with Para-aortic Lymphadenectomy for Endometrial Cancer: A Preliminary Report
Authors: Hayashi Shigehiro , Kojima Junya , Sasaki Toru , Yamamoto Akiko , Kato Kazuyoshi , Nishi Hirotaka 
Published: December 2023

Abstract

Objectives:
There are few reported cases of robot-assisted surgery for endometrial cancer with para-aortic lymphadenectomy (PAL) in Japan. Therefore, this study aimed to examine the clinical outcomes of robot-assisted surgery with PAL for endometrial cancer.

Materials and Methods:
This retrospective cohort study was analyzed 13 endometrial cancer patients who underwent robotic surgery with PAL between January 2011 and October 2018 at our hospital. We examined their perioperative complications and oncological outcomes.

Results:
The median follow-up period, median overall survival, and disease-free interval were 80 months, 79 months (61–120), and 79 months (5–120), respectively. There were two (15.3%) cases of perioperative complications of Clavien–Dindo Class II or higher and three (23.0%) cases of recurrence.

Conclusion:
Our results showed that the surgical and oncological outcomes of robot-assisted surgery for endometrial cancer with PAL were comparable with those of other developed countries.
The Current Trend of Fertility Preservation in Patients with Cervical Cancer
Authors: Liu Chih-Ku , Huang Kuan-Gen , Chen Ming-Jer , Lu Chien-Hsing , Hwang Sheau-Feng , Sun Lou , Hsu Shih-Tien 
Published: December 2023

Abstract
Although the incidence of most cancers increases with age, a considerable number of patients receive a diagnosis of cancer during their reproductive years. Young women wishing to get pregnant after cancer treatment should be provided consultation for fertility preservation and possible options. In patients with cervical cancer, hysterectomy is often inevitable because the uterus is located too close to the cervix. For young patients with cervical cancer who desire to get pregnant and whose lesion is confined to the cervix, sparing the uterus and, partially, the cervix should be prioritized as much as possible, while simultaneously ensuring favorable oncologic outcomes. In this review, we explore how to choose an adequate fertility-preserving procedure to achieve a balance between favorable oncologic outcomes and fertility and management during pregnancy after a radical trachelectomy in women with early-stage cervical cancer. For patients who require hysterectomy or radiation, evaluation of the ovarian condition and laparoscopic ovarian transposition followed by the use of artificial reproduction techniques and pregnancy by surrogacy should be discussed as options to achieve a successful pregnancy.
Does Local Infiltration of Anesthesia Reduce Port-site Pain in Gynecological Laparoscopic Surgeries? A Pilot Study
Authors: Malik Roopa , Verma Renu 
Published: December 2023

Objectives:
The objectives of this study were to evaluate the visual analog scale (VAS) score in patients receiving port-site bupivacaine infiltration in gynecological laparoscopic surgeries and to compare it with those receiving placebo and to evaluate the additional analgesic requirement in the first 24 h after surgery.

Materials and Methods:
A prospective interventional study was conducted on 60 women scheduled for benign gynecological laparoscopic surgeries. Patients were randomized into two groups using an alternative sequential method of allocation. Approval from the Institute’s Ethics Committee was sought. Informed written consent was taken from all the patients. All laparoscopic surgeries were performed under general anesthesia. Double-blinding was done. A VAS with a 10 cm vertical score ranging from “no pain” to “worst possible pain” was used to assess the postoperative pain when the patient awakened in the operating room (2 h after surgery), then after 6 and 24 h. The primary outcome measured was pain perception by the patient (as VAS scores), and the secondary outcome was the need for additional analgesia.

Results:
Comparison of both groups with the VAS score shows P > 0.001, i.e., nonsignificant in all the groups. Additional analgesics were required in 56% of the patients in the intervention group and 60% of the patients in the control group; however, 44% and 40% of the patients from the intervention and control groups, respectively, do not require any additional analgesic in the postoperative period.

Conclusion:
The local infiltration of bupivacaine does not significantly reduce the port-site postoperative pain in gynecological laparoscopic surgeries.
Vaginal Vault Closure Following Total Laparoscopic Hysterectomy: Laparoscopic versus Conventional Technique – A Comparative Study
Authors: Agarwal Mukta , Sinha Shivangni , Singh Smita , Haripriya H. , Simran S 
Published: December 2023

Objectives:
Vault closure is the final step to hysterectomy, protecting the abdominal cavity from the exterior environment. Thus, closure becomes crucial in preventing ascend of infection to the peritoneal cavity. Our study aims to compare vault closure between laparoscopic and vaginal routes, their operating time, and postoperative complications.

Materials and Methods:
The ambispective comparative study was done in a tertiary care teaching center from June 2016 to December 2022. Three hundred and forty-four patients were included in the study that underwent a total laparoscopic hysterectomy. Interventions – Patients who had laparoscopic vault closure were in Group 1 (N = 198) and those who had vaginal closure were in Group 2 (N = 146). The results were compared. It included age, body mass index of the patient, the indication of surgery, intraoperative blood loss, size of the uterus, time taken during vault closure, and postoperative complications.

Results:
The time taken by laparoscopic vault repair was significantly less than vaginal repair (19.7 ± 13.3 min vs. 30.1 ± 6.6 min, P < 0.001). There was postoperative vault infection (2.7%), vault hematoma (1.3%), and no vault prolapse seen in vaginal repair. The organisms isolated were mainly Pseudomonas aeruginosa, Escherichia coli, and Klebsiella.

Conclusion:
Laparoscopic vault closure has shown significantly improved results compared to vaginal route repair.
Robot-Assisted Versus Laparoscopic Surgery for Pelvic Lymph Node Dissection in Patients with Gynecologic Malignancies
Authors: Aiko Kiyoshi , Kanno Kiyoshi , Yanai Shiori , Sawada Mari , Sakate Shintaro , Andou Masaaki 
Published: December 2023

Abstract

Objectives:
The objective of this study was to compare the surgical outcomes for pelvic lymph node dissection (PLND) performed through conventional laparoscopic surgery (CLS) versus robot-assisted surgery (RAS) in patients with gynecologic malignancies.

Materials and Methods:
Perioperative data, including operative time, estimated blood loss, and complications, were retrospectively analyzed in 731 patients with gynecologic malignancies who underwent transperitoneal PLND, including 460 and 271 in the CLS and RAS groups, respectively. Data were statistically analyzed using the Chi-square test or Student’s t-test as appropriate. P < 0.05 was considered statistically significant.

Results:
The mean age was 50 ± 14 years and 53 ± 13 years in the RAS and CLS groups (P < 0.01), respectively. The mean body mass index was 23.4 ± 4.8 kg/m2 and 22.4 ± 3.6 kg/m2 in the RAS group and CLS groups (P < 0.01), respectively. The operative time, blood loss, and number of resected lymph nodes were 52 ± 15 min, 110 ± 88 mL, and 45 ± 17, respectively, in the RAS group and 46 ± 15 min, 89 ± 78 mL, and 38 ± 16, respectively, in the CLS group (all P < 0.01). The rate of Clavien-Dindo Grade ≥ III complications was 6.3% and 8.7% in the RAS and CLS groups, respectively (P = 0.17).

Conclusion:
Shorter operative time and lower blood loss are achieved when PLND for gynecologic malignancies is performed through CLS rather than RAS. However, RAS results in the resection of a greater number of pelvic lymph nodes.
Bipolar affective disorder in India: A multi-site population-based cross-sectional study
Authors: Vajawat Bhavika , Suhas Satish , Moirangthem Sydney , Kumar Channaveerachari Naveen , Varghese Mathew , Gururaj Gopalkrishna , Benegal Vivek , Rao Girish N. ,   NMHS National Collaborators Group
Published: December 2023

Introduction:
Bipolar Affective Disorder (BPAD) merits careful consideration within the medical and healthcare communities, researchers, and policymakers. This is due to its substantial disability burden, elevated prevalence of co-morbidities, heightened lifetime risk of suicidality, and a significant treatment gap. This article focuses on the lifetime and current prevalence, correlates, co-morbidities, associated disabilities, socio-economic impact, and treatment gap for BPAD in the adult population of the National Mental Health Survey (NMHS) 2016.

Materials and Methods:
The NMHS 2016 was a nationally representative study conducted across 12 Indian states between 2014 and 2016. A multi-stage, stratified, random cluster sampling technique based on probability proportionate to size at each stage was used. The diagnosis of BPAD was based on Mini-International Neuropsychiatric Interview 6.0.0. Sheehan's Disability Scale was used to assess the disability.

Results:
A total of 34,802 adults were interviewed. The overall weighted prevalence of BPAD was 0.3% [95% confidence interval (CI): 0.29–0.31] for current and 0.5% (95% CI: 0.49–0.51) for lifetime diagnosis. Male gender [odds ratio (OR) 1.56] and residence in urban metropolitans (OR 2.43) had a significantly higher risk of a lifetime diagnosis of BPAD. Substantial cross-sectional co-morbidities were noted as per MINI 6.0.0 with the diagnosis of current BPAD such as tobacco use disorder (33.3%), other substance use disorders (14.6%), and anxiety disorders (10.4%). Two-thirds of persons with current BPAD reported disability of varying severity at work (63%), social (59.3%), and family life (63%). The treatment gap for current BPAD was 70.4%.

Conclusion:
Most individuals with current BPAD reported moderate–severe disability. There were substantial co-morbidities and a large treatment gap. These warrant concentrated efforts from policymakers in devising effective strategies.
Ocular manifestations in a case of herpes zoster ophthalmicus with human immunodeficiency virus
Authors: Bindiya Chalattil , Veluri Haritha , Singh Manmeet 
Published: December 2023

Abstract
This is a case report of human immunodeficiency virus infection whose primary presentation was with herpes zoster ophthalmicus with sterile corneal perforation which is unusual. A 48-year-old female patient presented with redness and painful decrease in vision in the right eye for the past two weeks. Examination revealed skin lesions in right side of face, with complete ptosis in right eye with restricted ocular movements suggestive of third nerve palsy. Slit lamp examination revealed sterile perforated peripheral corneal ulcer in right eye. Screening of viral markers revealed that patient was positive for human immunodeficiency virus. The case was treated conservatively with oral antivirals, topical antibiotics, and lubricants. The patient was started on highly active antiretroviral therapy from nearby antiretroviral therapy centre. We planned to do a corneal patch graft for the patient but the patient was not willing for any surgical intervention.
Tear cytokines and their relevance as biomarkers in ocular surface inflammatory diseases
Authors: Gurumurthy Srividya , Bhambhani Varsha , Agarwal Shweta , Srinivasan Bhaskar , Iyer Geetha 
Published: December 2023

Abstract
Ocular surface disorders (OSDs) are complex, multifactorial diseases, often coexisting and with overlapping symptoms leading to discomfort and visual compromise. OSD is driven by chronic inflammation and its pathogenesis involves multiple ocular surface structures such as the cornea, conjunctiva, lacrimal glands, and meibomian glands.
Diagnosing and monitoring disease progression based on clinical features is crucial for effective treatment implementation. However, achieving a differential diagnosis solely through clinical features can be challenging. The evaluation of biomarkers can facilitate disease diagnosis, aid in classification, and offer insights into disease progression and treatment effectiveness. There remains an unmet clinical need for biological tools to manage ocular surface diseases (OSDs).
Tear fluid serves as a readily accessible source of biological material that has undergone extensive analysis in the quest for biomarkers related to OSD. Numerous studies have contributed to the extensive catalog of biomarkers found in tear fluid for OSD. The objective of this review is to provide a comprehensive and up-to-date overview of the most pertinent biomarkers for various OSDs, with a specific focus on quantitative analyses and their correlations with clinical parameters.
To achieve this objective, we conducted a review of the PubMed database from January 2013 to June 2023, including original articles that investigated tear cytokines in various OSD pathologies. These studies unveiled a dysregulated interplay of pro- and anti-inflammatory cytokines within these disease pathologies. Pro-inflammatory interleukins (IL-1β, IL-2, IL-8, and IL-17), tumor necrotic factor (TNF-α), interferon-gamma (IFN-γ), as well as IL-4, IL-5, and IL-13 (Th2 pathway), and chemokines such as CCL5, IP-10 (CXCL10), and CX3CL, appear to represent similar inflammatory mechanisms in OSD pathologies.
The cytokines identified through tear fluid analysis can aid in categorizing the disease as either pro-inflammatory or pro-fibrotic based on its severity, or they may serve as potential targets for intervention. This, in turn, can facilitate the planning of appropriate management strategies. The integration of biomarker testing into clinical settings holds the potential to advance personalized medicine and represents the next significant step in managing OSD.
Coronavirus Disease Outbreak: Assessing the Level of Preparedness for Containment in Healthcare Facilities in Nigeria: Qualitative Research Findings
Authors: Ayowole Damilola , Abdul-Azeez Muhammed , Uvere Ezinne O. , Adebayo Oladimeji , Okunade Praise T. , Oghenechodja Josephine 
Published: December 2023

Background:
The COVID-19 pandemic has raised serious public health concerns globally. Cases keep increasing across countries: exposing the emergency-containing capability, level of preparedness, emergency disease prevention, and risk management alertness of various healthcare facilities in managing the crisis.

Aim:
to assess the level of preparedness for the containment of the COVID-19 disease outbreak across health-care facilities in Nigeria.

Materials and Methods:
Participants were the stakeholders within selected healthcare facilities. Data were collected via in-depth interviews using a list of 37 structured questions to assess the level of preparedness of the Nigerian health-care facilities in containing the COVID-19 pandemic. The findings were manually and thematically analysed using the constructivist variant of the grounded theory methodology.

Results:
Overall, the level of preparedness across the selected health facilities was estimated as average, as several facilities were fairly prepared while a few others were relatively unprepared for the COVID-19 pandemic containment.

Conclusion:
The COVID-19 virus disease outbreak can be said to be fairly contained by the Nigerian health system from the standpoint of the available mortality and incidence indices. Meanwhile, there are still loopholes around financial, structural, and material provisions which are essential needs for better and sustainable pandemic containment.
Incidence and Predictive Factors of Lower Extremity Deep-vein Thrombosis in Patients with Neurological Diseases in a Sub-Saharan Tertiary Hospital
Authors: Campbell Francis Chukwuebuka , Ajare Enyereibe Chuks , Ndukuba Kelechi Onyenekeya , Okwunodulu Okwuoma , Hart Idawarifagha , Nnama Sunday Samuel , Azaatse Terngu Titus , Ndubuisi Chika Anele , Ohaegbulam Samuel 
Published: December 2023

Background:
Deep-vein thrombosis (DVT) is a major cause of morbidity among patients with neurological disease and is implicated in 50%–90% of pulmonary embolisms (PE).

Aim:
This study aims to identify the incidence and predictive factors of lower extremity (LE) DVT in high-risk neurological patients.

Materials and Methods:
All patients with neurological diseases who were confined to bed for three days or more, or had elevated D-dimer over a 22 months were included in the study. They all had routine mechanical and chemical prophylaxis. Serial color duplex ultrasonography of the LE was performed for all the patients, and the results were used to stratify them into two groups: DVT positive and DVT negative, and their clinical parameters were recorded and utilised for statistical analysis. Multivariate logistic regression analysis was used to determine the predictive risk factors.

Results:
A total of 611 patients were admitted, and 107 met the inclusion criteria. The mean age was 57 ± 17 years, with a male-to-female ratio of 1.7:1. Forty-four (41.4%) patients had DVT (overall incidence was 7.2%). Primary intracranial tumours and craniocerebral trauma accounted for 27.2% and 20.5% of aetiology, respectively. The comparative DVT-positive versus DVT-negative group D-dimer levels were 7.9 versus 4.9 mg/L (P = 0.0065), duration of immobility 65.0 versus 35.3 days (P = 0.0001), and length of hospital (LOH) stay 32.5 versus 18.2 days (P = 0.0001). The proximal LE vessels were involved in 64.2%. The PE risk was 0.98%, with three mortalities. The predictive factors on multivariate logistic regression were elevated D-dimers (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.1–4.45 P = 0.030) and preoperative immobility >seven days ([OR] 2.38, 95% [CL] 1.28–4.39 P = 0.042). Gender, C-reactive protein, Glasgow Coma Scale, comorbidities, LOH, and chronic steroid use were not predictive.

Conclusion:
The overall incidence of DVT and mortality from PE were low among patients with neurological diseases. Most thrombi involved proximal LE veins. Elevated D-dimers and preoperative immobility >seven days were predictive factors for LE DVT.
Pengaruh Modernisasi Sistem Administrasi, Peraturan, Kesadaran, Sanksi Perpajakan Terhadap Kepatuhan Wajib Pajak Orang Pribadi Di Wilayah Kabupaten Sleman
Authors: Priyani Septi , As’ari Hasim 
Published: December 2023

Penelitian ini bermaksud guna mengetahui pengaruh modernisasi sistem administrasi, Peraturan, Kesadaran, dan sanksi perpajakan terhadap kepatuhan wajib pajak orang pribadi di wilayah kabupaten Sleman tahun 2023. Karena jumlah individu dalam populasi tidak diketahui, maka digunakan non-probability sampling untuk pengumpulan sampel, dan purposive sampling digunakan untuk penentuan sampelnya dengan 99 responden. Metode kuesioner digunakan sebagai metode pengumpulan data. Sebelum dilakukan pembagian koesioner, agar diperoleh hasil yang sesuai dengan fakta, maka diperlukan uji coba instrumen guna diuji validitas serta reliabilitasnya. Teknik analisis data dikerjakan dengan uji asumsi klasik yakni uji heteroskedastisitas, uji multikolinearitas serta uji normalitas, sebagai syarat uji regresi dalam pengujian hipotesis. Uji koefisien korelasi dan uji koefisien determinasi merupakan rangkaian uji hipotesis yang diterapkan pada penelitian ini. Temuan dari penelitian ini: Modernisasi sistem administrasi perpajakan serta peraturan perpajakan mempunyai pengaruh signifikan positif terkait kepatuhan wajib pajak orang pribadi yang bekerja di rumah sakit wilayah kabupaten Sleman, sedangkan Kesadaran perpajakan serta sanksi perpajakan tidak berdampak terhadap kepatuhan wajib pajak pajak orang pribadi yang bekerja di rumah sakit di wilayah kabupaten Sleman
INTERTEXTUALITY AND INTERDISCURSIVITY IN POST-COLONIAL LANGUAGE POLICIES IN KENYA
Authors: Nganga Chege Samuel , Maroko Geoffrey , Ong’onda Anashia Nancy 
Published: December 2023

Addressing the intricate challenges within the realm of language planning and policy involves establishing meaningful connections between language policy texts, discourse, and actual language practices. Moreover, navigating connections across diverse domains, contexts, levels, layers, and scales presents a formidable challenge. Therefore, this study endeavours to unravel intertextual connections as a means of comprehending language-policy texts in the Kenyan context. Focusing on post-colonial language policies in Kenya, this paper explores intertextuality and interdiscursivity. Employing Fairclough's (1992) Critical Discourse approach, this analysis explores how language policy documents undergo decontextualization from prior discourses (intertextuality) and examine their correlation with different generic chains (interdiscursivity). The study employs a qualitative research design, specifically historical and documentary analysis. The study's findings reveal that post-colonial language policies exhibit links to both pre-colonial and current policy documents, showcasing vertical and horizontal intertextuality. Additionally, these policies are linked to a myriad of past and present discourses, such as those related to culture and diversity (interdiscursivity). Notably, the analysis of intertextuality and interdiscursive discourse reveals revisions to language policy and tracks the shifts in discourses surrounding this policy over time. In conclusion, this study emphasises that the meaningful interpretation of intertextuality and interdiscursivity renders language policy texts significant. It is anticipated that this research will shed light on understanding language policy through the lens of intertextuality and interdiscursivity, contributing to a more comprehensive perspective on language policy dynamics.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0089/a.php" alt="Hit counter" /></p>