bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing the gap in health economics data to support national cancer control plans in low‐ and middle‐income countries: The Childhood Cancers Budgeting Rapidly to Incorporate Disadvantaged Groups for Equity (CC‐BRIDGE) tool
Authors: Bolous Nancy S. , Chokwenda‐Makore Nester , Bonilla Miguel , Chingo Grace , Kambugu Joyce , Mulindwa Justin M. , Noleb Mugisha , Chitsike Inam , Bhakta Nickhill 
Published: December 2023

AbstractBackgroundNational cancer control plans (NCCPs) are complex public health programs that incorporate evidence‐based cancer control strategies to improve health outcomes for all individuals in a country. Given the scope of NCCPs, small and vulnerable populations, such as patients with childhood cancer, are often missed. To support planning efforts, a rapid, modifiable tool was developed that estimates a context‐specific national budget to fund pediatric cancer programs, provides 5‐year scale‐up scenarios, and calculates annual cost‐effectiveness.MethodsThe tool was codeveloped by teams of policymakers, clinicians, and public health advocates in Zimbabwe, Zambia, and Uganda. The 11 costing categories included real‐world data, modeled data, and data from the literature. A base‐case and three 5‐year scale‐up scenarios were created using modifiable inputs. The cost‐effectiveness of the disability‐adjusted life years averted was calculated. Results were compared with each country’s projected gross domestic product per capita for 2022 through 2026.ResultsThe number of patients/total budget for year 1 was 250/$1,109,366 for Zimbabwe, 280/$1,207,555 for Zambia, and 1000/$2,277,397 for Uganda. In year 5, these values were assumed to increase to 398/$5,545,445, 446/$4,926,150, and 1594/$9,059,331, respectively. Base‐case cost per disability‐adjusted life year averted/ratio to gross domestic product per capita for year 1, assuming 20% survival, was: $807/0.5 for Zimbabwe, $785/0.7 for Zambia, and $420/0.5 for Uganda.ConclusionsThis costing tool provided a framework to forecast a budget for childhood‐specific cancer services. By leveraging minimal primary data collection with existing secondary data, local teams obtained rapid results, ensuring that childhood cancer budgeting is not neglected once in every 5 to 6 years of planning processes.
Nickel Oxide Decorated MWCNTs Wrapped Polypyrrole: One Dimensional Ternary Nanocomposites for Enhanced Thermoelectric Performance
Authors: Bourenane Cherif Younes , Mekhalif Zineb , Abdous Slimane , Nedjar Linda , Mekki Ahmed , Bekkar Djelloul Sayah Zakaria , Rafai Souleymen 
Published: December 2023

AbstractThis study reports on a customized and revised approach to fabricate “nickel oxide decorated multi‐walled carbon nanotubes (MWCNTs) wrapped polypyrrole (PPy)” nanocomposite with enhanced room‐temperature thermoelectric (TE) properties. The nanocomposite is formed through three steps: MWCNTs functionalization via diazonium salt grafting of 5‐amino‐1,2,3‐benzene tricarboxylic acid; in situ generation on their surfaces of NiO nanoparticles with a homogenous distribution; the chemical polymerization of pyrrole using methyl orange as templating and dopant to wrap the MWCNTs‐(COOH)3‐NiO. Various techniques were used as characterization tools, including XRD, TEM, FTIR, Raman, TGA, XPS, and TE measurements. The PPy‐MWCNTs‐(COOH)3‐NiO nanocomposite exhibits significantly higher Seebeck coefficient, electrical conductivity, and power factor than PPy and PPy‐MWCNTs‐(COOH)3. The achieved enhancement in TE properties (figure of merit, ZTPPy‐MWCNTs‐(COOH)3‐NiO=1.51×10−2) is attributed to the presence of NiO, which acts as a dopant and improves the charge carrier density in the nanocomposite. These results offer the potential for waste heat recovery and large‐scale fabrication of high‐performance composites.
Kinetic and Thermodynamic Studies of Precious Metals Sorption on Impregnated Lewatit VP OC 1026 from Chloride Solutions
Authors: Zinkowska Karolina , Hubicki Zbigniew , Wójcik Grzegorz 
Published: December 2023

AbstractPrecious metals are used in many branches of industries. Due to their rarity and diminishing natural resources, more and more new methods are being sought to recover them from secondary sources, which can be electronic waste or spent car exhaust converters. This paper presents the research on the recovery of precious metals from chloride solutions using the Aliquat 336‐impregnated Lewatit VP OC 1026 sorbent. The study used a warm impregnation method without toxic solvents, which is beneficial for the environment. The maximal sorption capacities obtained for model solutions in 0.1 M HCl were: 95.6 mg/g for gold, 38.2 mg/g for palladium, and 36.2 mg/g for platinum. There were studied: kinetics and thermodynamics of sorption, as well as amounts of the sorbent, effects of phase contact time and HCl concentration on the sorption of precious metals. Positive values of enthalpy change ΔH° validate that the process is endothermic. The research was also carried out on a real leaching solution obtained by digesting a spent catalytic converter, containing small amounts of platinum group metals. Desorption of precious metal ions was conducted using 1 M thiourea in 1 M hydrochloric acid. The obtained impregnated sorbent proved to be effective for sorption of Au(III), Pd(II), Pt(IV) ions.
How gender diversity in boards affects disclosure? A literature review
Authors: Centinaio Alessandra 
Published: December 2023

AbstractA more gender‐balanced working environment is both a necessity and an opportunity for society. Women representation on corporate boards is among the most debated topics, and several legislative measures have recently been adopted to improve gender equality in boards. However, real progress requires firms to appoint women on boards not just as a matter of compliance. Thus, assessing the business implications of board gender diversity can support the adoption of new policies and prevent their reduction to mere tokenism. By applying a dynamic literature review method called ‘Systematic Literature Network Analysis’, this study provides an overview of the existing literature investigating the impact of board gender diversity on companies' level and quality of disclosure. Overall, researchers report a positive relationship. Some notable exceptions nevertheless call for further research to deepen our understanding of how enhanced gender equality in boards can improve corporate communication and transparency.
Preface to Special Issue on Sustainable Ammonia Synthesis
Authors: Macfarlane Douglas R. , Skúlason Egill , Hosono Hideo , Shao Minhua 
Published: December 2023

AbstractIn this Editorial, Guest Editors Douglas R. MacFarlane, Egill Skúlason, Hideo Hosono and Minhua Shao discuss the newly emerging field of electrochemical nitrogen reduction reaction (NRR) in the Special Issue of ChemSusChem on Sustainable Ammonia Synthesis.
Cognitive behavior therapy for adult eating disorders in routine clinical care: A systematic review and meta‐analysis
Authors: Öst Lars‐Göran , Brattmyr Martin , Finnes Anna , Ghaderi Ata , Havnen Audun , Hedman‐Lagerlöf Maria , Parling Thomas , Welch Elisabeth , Wergeland Gro Janne 
Published: December 2023

AbstractObjectiveCognitive behavior therapy (CBT) is a recommended treatment for eating disorders (ED) in adults given its evidence, mainly based on efficacy studies. However, little is known about how CBT works in routine clinical care. The goal of the present meta‐analysis is to investigate how CBT works for various ED when carried out in routine clinical settings.MethodOvid MEDLINE, Embase OVID, and PsycINFO were systematically searched for articles published until June 2023. The outcome of CBT, methodological quality, risk of bias (RoB), and moderators of treatment outcome were examined and benchmarked by meta‐analytically comparing with efficacy studies for ED. Fifty studies comprising 4299 participants who received CBT were included.ResultsLarge within‐group effect sizes (ES) were obtained for ED‐psychopathology at post‐treatment (1.12), and follow‐up (1.22), on average 9.9 months post‐treatment. Attrition rate was 25.5% and RoB was considerable in the majority of studies. The benchmarking analysis showed that effectiveness studies had very similar ESs as efficacy studies (1.20 at post‐treatment and 1.28 at follow‐up).ConclusionCBT for ED is an effective treatment when delivered in routine clinical care, with ESs comparable to those found in efficacy studies. However, the evidence needs to be interpreted with caution due to the RoB in a high proportion of studies.Public SignificanceEating disorders are common in the population and often lead to multiple negative consequences. CBT has been found effective for ED and is recommended in clinical guidelines. Since these recommendations are primarily based on university studies we wanted to investigate how CBT performs in routine clinical care. Our meta‐analysis found that CBT worked as well in routine care as in university setting studies.
Antiretroviral therapy and HIV‐associated cardiovascular disease: a prospective cardiac biomarker and CMR tissue characterization study
Authors: Robbertse Pieter‐Paul S. , Doubell Anton F. , Esterhuizen Tonya M. , Herbst Philip G. 
Published: December 2023

AbstractAimsBiochemical markers are fundamental in cardiac evaluation, and various novel assays have recently been discovered. We prospectively evaluated the hearts of newly diagnosed people living with human immunodeficiency virus (PLWH) using cardiac biomarkers, compared them with human immunodeficiency virus (HIV)‐uninfected controls, and correlated our prospective findings with cardiovascular magnetic resonance imaging (CMR).Methods and resultsNewly diagnosed, antiretroviral therapy (ART)‐naïve PLWH were recruited along with HIV‐uninfected, age‐matched, and sex‐matched controls. All participants underwent measurement of high‐sensitivity cardiac troponin T (hs‐cTnT), N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), soluble ST2 (sST2), and galectin‐3, as well as a CMR study with multiparametric mapping. The HIV group started ART and was re‐evaluated 9 months later. The cardiac biomarkers and their correlation with CMR parameters were evaluated in and between groups. Compared with controls (n = 22), hs‐cTnT (4.0 vs. 5.1 ng/L; P = 0.004), NT‐proBNP (23.2 vs. 40.8 ng/L; P = 0.02), and galectin‐3 (6.8 vs. 9.0 ng/mL; P = 0.002) were all significantly higher in the ART‐naïve group (n = 73). After 9 months of ART, hs‐cTnT (5.1 vs. 4.3 ng/L; P = 0.02) and NT‐proBNP (40.8 vs. 28.5 ng/L; P = 0.03) both decreased significantly and a trend of decrease was seen in sST2 (16.5 vs. 14.8 ng/L; P = 0.08). Galectin‐3 did not demonstrate decrease over time (9.0 vs. 8.8 ng/mL; P = 0.6). The cardiac biomarkers that showed the best correlation with CMR measurements native T1, T2, and extracellular volume were NT‐proBNP (rs ≥ 0.4, P < 0.001) and galectin‐3 (rs ≥ 0.3, P < 0.01).ConclusionsOur cardiac biomarker data support the presence of subclinical myocardial injury, remodelling, and fibrosis at HIV diagnosis, and ART had a positive influence on these blood markers. It remains unclear if the underlying pathological processes were fully addressed by ART. The ability of cardiac biomarkers to detect and track tissue abnormalities diagnosed with CMR showed promise. With additional research, this could lead to improvements in screening and monitoring myocardial abnormalities, even in CMR‐limited settings.
Sulfur‐Containing 1,2,3‐Triazoles: Synthesis and Properties
Authors: Peng Lifen , Chen Jiayi , Chen Yi , Lu Hao , Okuda Yasuhiro , Tang Zilong , Orita Akihiro , Qiu Renhua , Yin Shuang‐Feng 
Published: December 2023

AbstractSulfur‐containing 1,2,3‐triazoles display bioactivities like antidepressant, antifungal activity, antitumor, etc. Numerous approaches have been established to form sulfur‐containing 1,2,3‐triazoles. 4‐Sulfanyl‐ and 5‐sulfanyl‐1,2,3‐triazoles were produced by metal‐catalyzed azide‐alkyne cycloaddition (AAC), etc. N‐Sulfonyl‐1,2,3‐triazoles were generated via the reaction of acetylides with sulfonyl azides, CuAAC. 4‐Sulfonyl‐1,2,3‐triazoles were produced through [3+2] cycloaddition and reaction of azide with bromovinylsulfonyl fluoride. Although 5‐sulfonyl‐1,2,3‐triazoles were formed successfully via RuAAC, their synthetic approaches were very limited. 1‐Phosphinyl‐2‐sulfanylethynes were suitable substances to access sulfur‐ and phosphorus‐containing triazoles. In this review, the synthesis and properties of sulfur‐containing 1,2,3‐triazoles were highlighted. Initially, the properties of organosulfurs, 1,2,3‐triazoles and sulfur‐containing 1,2,3‐triazoles were briefly introduced. After stating the general procedures to construct 1,2,3‐triazole skeleton, the synthetic approaches and properties of sulfur‐involved 1,2,3‐triazoles were sorted and described in details. According to different kinds of sulfur‐containing 1,2,3‐triazoles, synthetic methods and features of 4‐sulfanyl‐1,2,3‐triazoles, 5‐sulfanyl‐1,2,3‐triazoles, N‐sulfonyl‐1,2,3‐triazoles, 4‐sulfonyl‐1,2,3‐triazoles, 5‐sulfonyl‐1,2,3‐triazoles, sulfur‐ and heteroatom‐containing 1,2,3‐triazoles were summarized.
Effect of sodium hypochlorite and ethylenediaminotetraacetic acid activated by laser and ultrasonic energy on surface morphology and chemical composition of intracanal dentin
Authors: Katunarić Adriana , Grgac Sandra Flinčec , Gabrić Dragana , Pavelić Božidar , Bago Ivona 
Published: December 2023

AbstractThe aim of the study was to evaluate the structural and chemical changes in intracanal dentin after root canal irrigation with sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) using additional activation with a novel Er:YAG Shock Wave‐Enhanced Emission Photoacoustic Streaming (SWEEPS), ultrasonic irrigation (UI), and Nd:YAG irradiation. Root canals of extracted human premolars were instrumented with distilled water and distributed into groups according to the irrigation protocol used: Group 1: conventional needle irrigation (CI) with 3% NaOCl; group 2: CI with 15% EDTA; and group 3: CI with NaOCl+EDTA. In group 4, root canals were irrigated with NaOCl+EDTA+NaOCl using the following techniques: CI (group 4A), SWEEPS (group 4B), UI (group 4C). In group 4D, root canals were finally irradiated with Nd:YAG laser. After the irrigation, the intracanal dentin sample was collected and analyzed using spectroscope with a Fourier transformation of infrared spectrum in Attenuated total reflection technique (FTIR‐ATR) to calculate apatite/collagen ratio. Scanning electron microscopy (SEM) and energy dispersive x‐ray spectrometry (EDS) were used to determine its chemical composition. FTIR‐ATR showed no significant difference in the phosphate/amid I ratio between the control and the experimental groups (p > 0.05). SWEEPS and UI of NaOCl+EDTA+NaOCl caused the most pronounced decrease of Ca and P (p < 0.05) value compared to CI and control group, and canal wall erosion. SWEEPS and UI of NaOCl+EDTA+NaOCl caused the most pronounced decrease of Ca and P value and significant canal wall erosion. However, no difference in phosphate/amide ratio was reported among groups.Research Highlights
SWEEPS and UI of NaOCl+EDTA+NaOCl caused the most pronounced decrease of Ca and P values and significant canal wall erosion.
There was no difference in phosphate/amide ratio among the irrigation protocols.
Free Water MR Imaging of White Matter Microstructural Changes is a Sensitive Marker of Amyloid Positivity in Alzheimer's Disease
Authors: Sun Xuan , Zhao Cui , Chen Si‐Yu , Chang Yan , Han Yu‐Liang , Li Ke , Sun Hong‐Mei , Wang Zhen‐Fu , Liang Ying , Jia Jian‐Jun 
Published: December 2023

BackgroundExtracellular free water (FW) resulting from white matter degeneration limits the sensitivity of diffusion tensor imaging (DTI) in predicting Alzheimer's disease (AD).PurposeTo evaluate the sensitivity of FW‐DTI in detecting white matter microstructural changes in AD. To validate the effectiveness of FW‐DTI indices to predict amyloid‐beta (Aβ) positivity in mild cognitive impairment (MCI) subtypes.Study TypeRetrospective.PopulationThirty‐eight Aβ‐negative cognitively healthy (CH) controls (68.74 ± 8.28 years old, 55% female), 15 Aβ‐negative MCI patients (MCI‐n) (68.87 ± 8.83 years old, 60% female), 29 Aβ‐positive MCI patients (MCI‐p) (73.03 ± 7.05 years old, 52% female), and 29 Aβ‐positive AD patients (72.93 ± 9.11 years old, 55% female).Field Strength/Sequence3.0T; DTI, T1‐weighted, T2‐weighted, T2 star‐weighted angiography, and Aβ PET (18F‐florbetaben or 11C‐PIB).AssessmentFW‐corrected and standard diffusion indices were analyzed using trace‐based spatial statistics. Area under the curve (AUC) in distinguishing MCI subtypes were compared using support vector machine (SVM).Statistical TestsChi‐squared test, one‐way analysis of covariance, general linear regression analyses, nonparametric permutation tests, partial Pearson's correlation, receiver operating characteristic curve analysis, and linear SVM. A P value <0.05 was considered statistically significant.ResultsCompared with CH/MCI‐n/MCI‐p, AD showed significant change in tissue compartment indices of FW‐DTI. No difference was found in the FW index among pair‐wise group comparisons (the minimum FWE‐corrected P = 0.114). There was a significant association between FW‐DTI indices and memory and visuospatial function. The SVM classifier with tissue radial diffusivity as an input feature had the best classification performance of MCI subtypes (AUC = 0.91), and the classifying accuracy of FW‐DTI was all over 89.89%.Data ConclusionFW‐DTI indices prove to be potential biomarkers of AD. The classification of MCI subtypes based on SVM and FW‐DTI indices has good accuracy and could help early diagnosis.Evidence Level4Technical EfficacyStage 2
mRNA‐HPV vaccine encoding E6 and E7 improves therapeutic potential for HPV‐mediated cancers via subcutaneous immunization
Authors: Lee Seonghyun , Yoon Hyunho , Hong Seol Hee , Kwon Sung Pil , Hong Jung Joo , Kwak Hye Won , Park Hyeong‐Jun , Yoo Soyeon , Bae Seo‐Hyeon , Park Hyo‐Jung , Lee Jisun , Bang Yoo‐Jin , Lee Yu‐Sun , Kim Jae‐Yong , Yoon Subin , Roh Gahyun , Cho Youngran , Kim Yongkwan , Kim Daegeun , Park Sang‐In , Kim Do‐Hyung , Lee Sowon , Oh Ayoung , Ha Dahyeon , Lee Soo‐Yeon , Park Misung , Hwang Eun‐Ha , Bae Gyuseo , Jeon Eunsu , Park Sung Hyun , Choi Won Seok , Oh Ho Rim , Kim In Woo , Youn Hyewon , Keum Gyochang , Bang Eun‐Kyoung , Rhee Joon Haeng , Lee Shee Eun , Nam Jae‐Hwan 
Published: December 2023

AbstractThe E6 and E7 proteins of specific subtypes of human papillomavirus (HPV), including HPV 16 and 18, are highly associated with cervical cancer as they modulate cell cycle regulation. The aim of this study was to investigate the potential antitumor effects of a messenger RNA‐HPV therapeutic vaccine (mHTV) containing nononcogenic E6 and E7 proteins. To achieve this, C57BL/6j mice were injected with the vaccine via both intramuscular and subcutaneous routes, and the resulting effects were evaluated. mHTV immunization markedly induced robust T cell‐mediated immune responses and significantly suppressed tumor growth in both subcutaneous and orthotopic tumor‐implanted mouse model, with a significant infiltration of immune cells into tumor tissues. Tumor retransplantation at day 62 postprimary vaccination completely halted progression in all mHTV‐treated mice. Furthermore, tumor expansion was significantly reduced upon TC‐1 transplantation 160 days after the last immunization. Immunization of rhesus monkeys with mHTV elicited promising immune responses. The immunogenicity of mHTV in nonhuman primates provides strong evidence for clinical application against HPV‐related cancers in humans. All data suggest that mHTV can be used as both a therapeutic and prophylactic vaccine.
Autoantibodies against angiotensin‐converting enzyme 2 (ACE2) after COVID‐19 infection or vaccination
Authors: Tsoi James Yiu Hung , Cai Jianpiao , Situ Jianwen , Lam Winston Jim , Shun Estie Hon Kiu , Leung Joy Ka Yi , Chen Lin Lei , Chan Brian Pui Chun , Yeung Man Lung , Li Xin , Chan Kwok Hung , Wong Joshua Sung Chih , Kwan Mike Yat Wah , To Kelvin Kai Wang , Yuen Kwok Yung , Sridhar Siddharth 
Published: December 2023

AbstractAutoantibodies against angiotensin‐converting enzyme 2 (ACE2) are frequently reported in patients during coronavirus disease 2019 (COVID‐19) with evidence for a pathogenic role in severe infection. However, little is known of the prevalence or clinical significance of ACE2 autoantibodies in late convalescence or following COVID‐19 vaccination. In this study, we measured ACE2 autoantibodies in a cohort of 182 COVID‐19 convalescent patients, 186 COVID‐19 vaccine recipients, and 43 adolescents with post‐mRNA vaccine myopericarditis using two ACE2 enzymatic immunoassays (EIAs). ACE2 IgM autoantibody EIA median optical densities (ODs) were lower in convalescent patients than pre‐COVID‐19 control samples with only 2/182 (1.1%) convalescents testing positive. Similarly, only 3/182 (1.6%) convalescent patients tested positive for ACE2 IgG, but patients with history of moderate‐severe COVID‐19 tended to have significantly higher median ODs than controls and mild COVID‐19 patients. In contrast, ACE2 IgG antibodies were detected in 10/186 (5.4%) COVID‐19 vaccine recipients after two doses of vaccination. Median ACE2 IgG EIA ODs of vaccine recipients were higher than controls irrespective of the vaccine platform used (inactivated or mRNA). ACE2 IgG ODs were not correlated with surrogate neutralizing antibody levels in vaccine recipients. ACE2 IgG levels peaked at day 56 post‐first dose and declined within 12 months to baseline levels in vaccine recipients. Presence of ACE2 antibodies was not associated with adverse events following immunization including myopericarditis. One convalescent patient with ACE2 IgG developed Guillain−Barre syndrome, but causality was not established. ACE2 autoantibodies are observed in COVID‐19 vaccine recipients and convalescent patients, but are likely innocuous.
How trace plots help interpret meta‐analysis results
Authors: Röver Christian , Rindskopf David , Friede Tim 
Published: December 2023

AbstractThe trace plot is seldom used in meta‐analysis, yet it is a very informative plot. In this article, we define and illustrate what the trace plot is, and discuss why it is important. The Bayesian version of the plot combines the posterior density of , the between‐study standard deviation, and the shrunken estimates of the study effects as a function of . With a small or moderate number of studies, is not estimated with much precision, and parameter estimates and shrunken study effect estimates can vary widely depending on the correct value of . The trace plot allows visualization of the sensitivity to along with a plot that shows which values of are plausible and which are implausible. A comparable frequentist or empirical Bayes version provides similar results. The concepts are illustrated using examples in meta‐analysis and meta‐regression; implementation inRis facilitated in a Bayesian or frequentist framework using thebayesmetaandmetaforpackages, respectively.