bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 pandemic shifted epidemiology for cancer screening sites: breast, cervix, colon, and rectum
Authors: Ishkinin Yevgeniy , Kaidarova Dilyara , Nazarbek Serzhan , Zhylkaidarova Alma , Ossikbayeva Saniya , Mussina Kamilla , Omarbayeva Nazgul 
Published: January 2025

BackgroundThis study aimed to assess the epidemiological changes in breast, cervical, colon, and rectal cancers in Kazakhstan before and during COVID-19, including early-onset cancer (EOC) diagnosed between the ages of 20 and 49, using data from the oncological service of the Republic of Kazakhstan for the 2017–2022 period.MethodsThe cohort comprised patients aged 20 to 49 years (EOC) and 50 years and older [late-onset cancer (LOC)] from the total number of patients diagnosed each year during the study period of 2017 to 2022 for breast, cervical, colon, or rectal cancer. In order to indicate a difference in one-time intervals and characterize the global trend over the entire study period, annual percentage change (APC) and average APC (AAPC) were calculated, respectively.ResultsBreast cancer detection rates increased by 22.8% for EOC and 15.9% for LOC from 2017 to 2022, and AAPC increased by 4.3% for EOC and 3.6% for LOC. During the COVID-19 restriction period, breast cancer detection rates decreased by 6.1% for EOC and 15.6% for LOC. Cervical cancer detection rates increased by 2.3% for EOC and 7.5% for LOC from 2017 to 2022, and AAPC increased by 0.9% for EOC and 1.6% for LOC. During the COVID-19 restriction period, cervical cancer detection rates decreased by 11.3% for EOC and 3.1% for LOC. Colon cancer detection rates increased by 18.4% for EOC and 14.3% for LOC from 2017 to 2022, and AAPC increased by 3.7% for EOC and 2.9% for LOC. During the COVID-19 restriction period, colon cancer detection rates decreased by 14.4% for EOC and 5.8% for LOC. Rectal cancer detection rates increased by 13.6% for EOC and 19.2% for LOC from 2017 to 2022, and AAPC increased by 3.0% for EOC and by 3.9% for LOC. During the COVID-19 restriction period, rectal cancer detection rates increased by 18.6% for EOC and decreased by 12.0% for LOC.ConclusionThe epidemiological indicators of population cancer screening worsened during the COVID pandemic; the detection rate decreased by 6.1% for breast EOC and 11.3% for cervical EOC, while there was an increase by 38.0% in EOC for colon cancer in men and by 8.0% in EOC for rectal cancer in men and 31.1% in women.
Analysis of the diagnostic efficacy of ultrasound, MRI, and combined examination in benign and malignant breast tumors
Authors: Ma Dianpei , Wang Changliang , Li Jie , Hao Xiaohan , Zhu Yun , Gao Zhizhen , Liu Chun , Luo Changfan , Huang Yu 
Published: January 2025

BackgroundTo compare the diagnostic effectiveness of ultrasound (US), magnetic resonance imaging (MRI), and their combined application in distinguishing between benign and malignant breast tumors, with particular emphasis on evaluating diagnostic performance in different breast densities—fatty breast tissue, where fat predominates, and dense breast tissue, which contains a significant amount of fibroglandular tissue.Materials and methodsA retrospective analysis was conducted on 185 patients with breast tumors, including 90 malignant and 95 benign cases. All patients underwent both US and MRI examinations within one week prior to surgery. The diagnostic accuracy of US, MRI, and their combined use in differentiating benign and malignant tumors was evaluated.ResultsThe combined examination demonstrated the highest area under the curve (AUC), sensitivity, and negative predictive value (NPV) (0.904, 90%, 90.4%), outperforming US (0.830, 73.3%, 78.6%) and MRI (0.897, 89.7%, 88.8%). DeLong test results revealed statistically significant differences in AUC between US and MRI, as well as between US and the combined examination (P &lt; 0.05). However, the difference in AUC between MRI and the combined examination was not significant (P = 0.939). In patients with fatty breast tissue, no significant differences were found between MRI and US, or between MRI and the combined examination (P = 0.708 and P = 0.317, respectively). However, the diagnostic performance between US and the combined examination was statistically significant (P &lt; 0.05). For patients with dense breast tissue, the differences in diagnostic performance between US and MRI, and between US and the combined examination, were significant (P &lt; 0.05), while the difference between MRI and the combined examination was not significant (P = 0.317).ConclusionMRI and combined examination methods significantly enhance the ability to differentiate benign and malignant breast tumors and provide important clinical value for early breast cancer detection.
Risk factors for malignancy in pediatric subacute/chronic focal craniocervical lymphadenopathy
Authors: Haimi-Cohen Yishai , Elron Eyal , Oz-Alcalay Lital , Hejly Lama , Hod Roy , Ashkenazi-Hoffnung Liat 
Published: January 2025

AimsTo describe the factors associated with malignancy in otherwise healthy children with focal persistent isolated craniocervical lymphadenopathy at low risk for malignancy, in order to aid in decisions of nodal surgical excision.Material and methodsDemographic and clinical data were retrospectively obtained for children with subacute and chronic craniocervical lymphadenopathy, treated from January 2008 to December 2020 at a general pediatric ambulatory clinic of a tertiary center. Univariate and multivariate analyses of risk factors for malignancy were performed.ResultsOf the 450 children included, median age 4.2 years (interquartile age: 2.4–8.7), 25 (5.6%) were eventually diagnosed with a malignancy. In univariate analysis, factors associated with malignancy included older age, increased nodal size, location (supraclavicular and lateral cervical), systemic signs such as decreased appetite and weight loss, and abnormal imaging studies. Referral by an ear, nose, throat specialist vs. a family physician or a pediatrician was also associated with malignancy. Fever, night sweats, pruritus, hepatosplenomegaly and laboratory workup were not associated with malignancy. Twenty percent of the children older than 12.5 years and 12% of those with a lymph node diameter &gt;31 mm were diagnosed with malignancy. Multivariate analysis showed associations with malignancy of older age and larger lymph nodes; the respective odds ratios were 1.649 (95%CI: 1.197–2.349, p = 0.004) for every 3 years and 2.080 (95%CI: 1.292–3.330, p = 0.002) for every one centimeter.ConclusionsOlder age and increased nodal size can help identify children with focal craniocervical lymphadenopathy who are at increased risk for malignancy and for whom surgical intervention should be strongly considered.
Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage
Authors: Hanna Mira , Akabawy Ahmed M. A. , Khalifa Mohamed Mansour , Elbaset Marawan Abd , Imam Reda Abdelnasser , Seddiek Hanan 
Published: January 2025

Sepsis, the most common cause of acute kidney injury, remains a major socioeconomic burden. A dysregulated immune response leads to progressive organ dysfunction. Although numerous inflammatory pathways were described, most are still vague and need to be studied in terms of the mechanisms to improve the therapeutic intervention. We tackled the relationship between intracellular iron overload and macrophage polarization within 6, 24, and 72 h of sepsis induction. In our study, sepsis-induced kidney injury was caused by using the cecal ligation and puncture (CLP) model. Our results indicated severe renal tissue damage with a progressive increase in serum BUN and creatinine with architectural tissue damage and positive PAS staining. There was increased expression of CD8+ CD68+ M1 macrophage markers with upregulation of iNOS and co-expression of CD163+. Alternatively, Arg1+ Fizz1+ M2 macrophage markers were downregulated with increased iNOS/Arg1 ratio. TFR1, cubilin, and DMT1, as iron transport systems, were increased compared to sham but were significant after 72 h, while ZIP8 showed no significant change. There was a correlation between iron overload and M1 macrophage polarization with CD163+ phenotype, together with fibrotic changes. The intracellular iron overload with downregulation of ferritin was strongly related to macrophage polarization that was exaggerated at 72 h. Finally, early introduced therapy to target free iron during sepsis is a proposed novel solution for protecting the renal tissue from acute injury due to macrophage activation that may end up with chronic kidney injury, if not mortality.
Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation
Authors: Barrett Douglas W. , Davis Roger E. , Siegel-Ramsay Jennifer E. , Bichlmeier Amy , Almeida Jorge R. C. , Gonzalez-Lima F. 
Published: January 2025

BackgroundConverging evidence suggests that bipolar disorder (BD) involves mitochondrial dysfunction and prefrontal cortex (PFC) hypometabolism associated with cognitive impairment, which persists in remitted BD individuals. Transcranial infrared laser stimulation (TILS) provides safe, non-invasive brain stimulation that enhances PFC metabolism via photobiomodulation of mitochondrial respiration and tissue oxygenation. We tested the hypothesis that the neurocognitive deficits found in BD may be ameliorated by TILS treatments.MethodsThis is the first study to explore neurocognitive effects of repeated TILS administration in BD. Using an open-label design, 29 individuals with remitted BD received six weekly TILS treatments. Working memory and attention were assessed with trail-making and 2-back tasks sensitive to TILS cognitive effects in individuals with BD. Changes in PFC network interactions were measured with functional near-infrared spectroscopy (fNIRS) because this method can measure TILS effects on oxygen metabolism in the PFC of individuals with BD.ResultsParticipants reported no adverse effects from treatment, confirming the safety of this intervention in individuals with BD. Cognitive test results showed that in people with remitted BD, TILS was effective at improving cognition, i.e., enhanced speed and accuracy in tasks reflecting cognitive flexibility, working memory, and attentional control. Antipsychotic medication improved TILS cognitive effects. The fNIRS results showed a significant reduction in PFC network correlations of oxygenated hemoglobin changes driven by cognitive task performance. The right-hemisphere frontopolar cortex showed greater TILS effects than its left-hemisphere counterpart.ConclusionsRepeated TILS is a safe intervention to improve cognition in people with remitted BD. Continued antipsychotic medication may have contributed to the cognitive improvement. To confirm TILS efficacy, a sham-controlled, double-blinded randomized trial is needed.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT05354895.
The double-edged sword effect of conscientiousness on the work engagement of medical staff in Chinese public hospitals
Authors: Sun Hui , Hua Xuelu , Wu Shibing , Sun Ling 
Published: January 2025

BackgroundIn China, medical staff in public hospitals are the primary providers of healthcare services. Their work engagement directly affects patients’ perceptions of the level and quality of their medical services. Conscientiousness has a significant impact on the work engagement of medical staff, but the mechanism between the two is not yet clear.ObjectiveThis study examined the double-edged sword effect of conscientiousness on medical staff work engagement, with a particular focus on exploring the mediating effects of thriving at work (TAW) and workload, as well as the moderating effect of perceived insider status (PIS).MethodsThe study sample was drawn from four public hospitals in the Jiangsu Province, Shanghai City, and Zhejiang Province. Data were statistically analyzed using SPSS, and mediation and moderations effects tested were conducted through the Bootstrap method.ResultsThe results demonstrate the following: (1) conscientiousness has a positive effect on the work engagement of medical staff; (2) conscientiousness has a positive effect on work engagement through thriving at work (TAW), and a negative effect on work engagement through workloads; (3) perceived insider status (PIS) moderates the relationship between conscientiousness and TAW, and the relationship between conscientiousness and workloads; and (4) PIS moderates the indirect effect of conscientiousness on work engagement through TAW, whereas the mediated relationship is strengthened when medical staff members exhibit a higher PIS. Simultaneously, PIS moderates the indirect effect of conscientiousness on work engagement through workload, and the mediating relationship is weakened for medical staff members who have a higher PIS.ConclusionThis study provides a balanced and dialectical understanding of the impact of conscientiousness, providing significant reference for enhancing the work engagement of medical staff in public hospitals.
Wildfire indicators modeling for reserved forest of Vellore district (Tamil Nadu, India)
Authors: Sultan Yara EzAl Deen , Pillai Kanni Raj Arumugam , Sharma Archana 
Published: January 2025

Forest fires significantly impact ecosystems; thus, identifying characteristics that increase the danger of fires is critical to mitigating their negative impacts. This study examines the parameters contributing to wildfires in the Vellore Reserve Forest This paper aims to develop GIS-based risk maps and models to enhance fire protection, fuel mitigation strategies, and land use decisions by improving wildfire risk recognition and prediction. This research discusses Wildfire Modeling in Vellore Reserve Forest, Tamil Nadu, India. This field is large and rich in knowledge on the study of wildfires in the study area. Tamil Nadu, India’s southernmost state, is divided into 32 districts with diverse landscapes and ecosystems. The Vellore district, covering 6,077 square kilometers, has a significant 27% forest cover, covering 162,286 ha. This forest is primarily found between latitudinal and longitudinal coordinates in the calm taluks of Gudiyatham, Tirupattur, and Vellore—the Vellore Reserve Forest Report 2023 highlights this ecological diversity. Geographic information systems (GIS) based analysis of forest fire was done using normalized difference vegetation index, normalized difference moisture index, fuel danger index (human) activity danger index, weather danger index, topographic danger index, normalized burn ratio index, and differenced Normalized Burn Ratio. The geographical scope of this research encompasses the entire Vellore district of Tamil Nadu, India. Real-time maps were photographed by MODIS and Landsat nine satellites to obtain a normalized difference in vegetation and moisture index. Initially, data are converted to digital maps. The most helpful fuel, activity, weather, and topography danger indexes are calculated using the Raster Calculator utility, Euclidean Distance tool, Kriging tool, and Digital Elevation Model, respectively. In the Vellore district, the calculated activity danger index ranges from 0 to 12,000, showing that the high risk emanates from human activities. The climate is dry from May to July, and the weather danger index is 345–348. In other seasons, the weather index is 338–341, indicating a low-risk level. In Vellore, low to medium-risk values for the topography index are 56.5–933, and high-risk values are 934–1,690. Fire severity is indexed in terms of both NBR and dNBR. NBR and dNBR are calculated from the NIR-SWIR ratio. Despite the limited data sources being a big challenge in this paper, the innovative elements of this study are characterized by a comprehensive, integrated strategy that employs GIS technology, providing an understanding of localized factors influencing wildfire ignition. This research contributes significant data and insights regarding the metrics that govern wildfire dynamics, serving as a vital resource for wildfire management efforts in the region. This paper assists in applying the models to predict the future wildfire risk under climate change and land use conditions.
Relationship between physical activity during pregnancy and maternal health outcomes: evidence from the MAASTHI cohort study in Bengaluru, India
Authors: Ana Yamuna , van den Brand Floor A. , van Schayck Onno C. P. , Babu Giridhara R. 
Published: January 2025

BackgroundSedentary behavior is one of the major modifiable behavioral risk factors for non-communicable diseases. Physical activity (PA) is crucial during pregnancy but pregnant women may become sedentary, leading to adverse health outcomes. Our study aimed to explore the association between social support and PA levels during pregnancy and the relationship between sedentary behavior and adverse pregnancy health outcomes including delivery.MethodsThe study used a validated physical activity questionnaire to assess the physical activity levels of pregnant women. We collected detailed sociodemographic information, pregnancy characteristics, assessed social support. We assessed presence of depressive symptoms and conducted oral glucose tolerance tests, hemoglobin and blood pressure assessments, anthropometric measurements, and collected delivery details. We used linear logistic regression to assess the association between a continuous measure of physical activity level and maternal outcomes and performed multivariable logistic regression analysis to understand the association between sedentary behavior and maternal health outcomes and mode of delivery after adjusting for potential confounders.ResultsWe interviewed 2,424 eligible pregnant women at baseline and 1,317 were considered in the final analysis after excluding those who missed follow-ups. We observed that one unit increase in physical activity level was associated with reduced prenatal depressive symptoms (β = −6.36, p &lt; 0.001), fasting (β = 2.06, p = 0.04), and postprandial blood sugar levels (β = −0.99, p = 0.01), respectively. Pregnant women who had good social support tended to engage in higher levels of activity. In addition, women who engaged in sedentary behavior during pregnancy were 1.07 times more likely to be obese and 4.32 times more likely to have elective cesarean section (C-section) delivery than those who engaged in moderate activity.ConclusionThe study found that physical activity during pregnancy has several beneficial effects on maternal prenatal health outcomes, including a reduced risk of obesity and C-section delivery, lower blood glucose levels, and improved mental health. Therefore, it is essential to adhere to the recommended guidelines for physical activity during pregnancy. Healthcare providers and policymakers in India should consider promoting physical activity as part of comprehensive routine prenatal care.
Les ambassades grecques à la cour du Grand Roi. Des missions pas comme les autres ?
Authors: Lenfant Dominique 
Published: January 2025

Aux Ve et IVe siècles av. J.-C., des cités grecques d’Europe envoyèrent régulièrement des ambassades à la cour du roi de Perse. On indique d’abord ici les particularités et limites de nos principales sources sur le sujet, avant d’analyser successivement les critères de choix des ambassadeurs, les modalités de leur voyage jusqu’au cœur de l’empire, les traits distinctifs de leur séjour à la cour et les conditions de leur retour dans leur cité, avec ses répercussions culturelles. Ces ambassades n’étaient pas des missions diplomatiques comme les autres. Il s’agissait d’une expérience sans équivalent, marquée par la découverte d’un univers nouveau, celui de l’empire perse, avec son territoire immense, son administration vigilante, son organisation logistique, ses richesses matérielles et son roi tout-puissant. Bien que les récits grecs n’y insistent guère, les ambassadeurs surent parfaitement s'adapter aux différences culturelles auxquelles ils firent face.
Rancang Bangun Sistem Informasi Akuntansi Berbasis Web pada Toko Sparepart Sepeda Motor
Authors: Selaningrum Ika Fitria , Ediraras Dharma Tintri 
Published: January 2025

<p>Penelitian ini bertujuan untuk merancang Sistem Informasi Akuntansi (SIA) untuk pelaporan keuangan Toko Sparepart Sepeda Motor. Objek penelitian ini adalah Toko Lancar Motor 2, di kota Bekasi. Penelitian ini dibatasi pada luaran Sistem Informasi Akuntansi yaitu laporan arus kas. Unit analisis adalah bukti transaksi berupa bukti penerimaan dan pengeluaran kas dari data pemilik toko. Pada penelitian ini dirancang sistem informasi akuntansi laporan keuangan berbasis web pada Toko Lancar Motor 2 dengan menggunakan perancangan sistem diagram UML. Pada tahap ini, tiga jenis diagram UML akan digunakan yaitu use case diagram, activity diagram, dan sequence diagram. Lalu dilakukan perancangan antarmuka pengguna yang intuitif, user-friendly, dan memudahkan pengguna dengan aplikasi desain Figma. Hasil dari penelitian ini adalah rancangan sistem informasi akuntansi yang mengatasi masalah-masalah yang diidentifikasi sebelumnya. Sistem ini diharapkan dapat mempercepat dan memudahkan proses pengelolaan laporan keuangan serta menghasilkan data yang akurat dan up-to-date bagi Toko Lancar Motor 2.</p>
Meta Analisis : Dialectical Behavioral Therapy dalam Menangani Binge Eating Disorder
Authors: Kirana Tesya 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui efektivitas Dialectical Behavioral Therapy dalam menangani Binge Eating Disorder dengan menggunakan metode meta-analysis. Penelitian ini dilakukan dengan cara melakukan literature review pada 14 jurnal internasional yang relevan dengan variabel penelitian. Effect size yang diperoleh dari random effect adalah sebesar 0,762 (95% CI = 0,98 sampai dengan 0,53, p = 0,0001), dengan I2 (inconsistency) 50,8% (95% CI = 0% to 71,9%). Dengan demikian, dapat dikatakan bahwa intervensi Dialectical Behavioral Therapy merupakan intervensi yang efektif secara signifikan dalam menurunkan intensitas Binge Eating Disorder dengan effect size yang cukup besar.
IMPACT OF GREEN PARTS POWDER OF LOCALLY CULTIVATED CARROT (DAUCUS CAROTA L.) ON QUALITATIVE AND SENSORY PROPERTIES OF BISCUITS AND CAKE
Authors: N. S. Mahdi  , K. A. Shakir  
Published: January 2025

The current study aimed to identify the effect of adding different concentrations (0%, 1%, 2%, 3%, and 4%) of carrot green parts powder (CGP) into biscuit and cake mixes on final products qualitative and sensory characteristics. The chemical analysis showed that the protein, ash, and fiber contents for wheat flour and for CGP were (10.64%, 0.88%, and 0.48%) and (16.4%, 19.4%, and 18.65%) respectively. While for the final products the percentages of protein and ash ranged from (10.36% -12.80% protein, 1.03%-1.53% ash) for cake treatments and (13.00 % -20.00% protein, 0.92%-1.43%ash) for biscuits treatments respectively. There was no significant variation among the width averages of biscuit treatments. The highest value for both spread ratio and spread factor were seen in treatments with 2 and 3% added powder. The sensory evaluation analysis indicated that there were no notable differences among the treatments in terms of external characteristics (the nature of surface and crust color). Although the internal characteristics were significantly affected by CGP concentrations, the overall scores for acceptance of the final product showed no significant differences among treatments. Regarding the cake samples, there were no significant differences in external characteristics among the treatments, except the color of the crust for treatment with 2% CGP and the crumb texture (porosity) and the overall acceptance in treatments with 1 and 2%of CGP which showed, significant differences.