bluuebunny/crossref_metadata_2025_split huggingface dataset:
The change of antibiotic resistance rates over the years in Enterococcus spp. isolated from clinical specimens
Authors: GEDİK Tuğba , KİRAZ Nuri , DURAN Hülya 
Published: October 2023

Aims: The aim of this study was to retrospectively evaluate the change in antibiotic resistance rates of Enterococcus species isolated from various clinical samples of outpatients and inpatients in our hospital over the years.
Methods: Between January 2018 and December 2021, various clinical samples sent to Tekirdağ Namık Kemal University Hospital Microbiology Laboratory from outpatients, inpatients and intensive care patients were retrospectively examined. The samples were inoculated on 5% sheep blood agar, chocolate agar and EMB agar media according to their types and incubated at 37°C. The blood cultures were performed by BACTEC 1280 System (Becton Dickinson, MA, USA). Bacterial identification and antimicrobial sensitivity tests were made using conventional methods and automated systems.
Results: A total of 417 Enterococcus strains were isolated in our laboratory at four years and included in the study. Of the 417 isolates, 204 (48.9%) were isolated from male patients and 213 (51.1%) from female patients. The mean age of the patients was 57.79±22.9 years (0-96 years). It was determined that 36.9% of the isolates belonged to outpatients, 33.4% to inpatients and 29.7% to intensive care unit patients. Of the 122 enterococci isolates identified as species, 49.2% were typed as Enterococcus faecalis (E. faecalis) and 40.2% as Enterococcus faecium (E. faecium). Of the 417 isolates, 60.4% were isolated from urine samples, 24.2% from blood samples, and 8.9% from wound samples. Considering the total antibiotic resistance rates; ampicillin was 34.9%, ciprofloxacin was 46.4%, vancomycin was 8.4%, tigecline was 3.2%, high-level gentamicin was 49.0%. Linezolid and nitrofurantoin resistance were not detected. Ampicillin and vancomycin resistance rates were determined to have a statistically significant increase within four years. Ampicillin, ciprofloxacin, vancomycin and high-level gentamicin resistance rates were found to be significantly higher in isolates obtained from inpatients and intensive care patients compared to enterococcal isolates obtained from outpatients.
Conclusion: In our study, it was determined that antibiotic resistance in enterococcal isolates, which are the causative agents of infection in our hospital, increased over the years. In this way, determining the change in antibiotic resistance rates is beneficial in determining appropriate antibiotic use policies. It is thought that conducting surveillance studies on antibiotic resistance periodically and taking new measures according to changing antibiotic resistance rates will be beneficial in terms of treatment.
Characteristics and effects of headaches on quality of life in individuals with epilepsy in Çorum province of Turkey
Authors: ELİAÇIK Sinan , AYKAÇ Serdar 
Published: October 2023

Aims: Varying headache prevalence rates have been reported in individuals with epilepsy in the literature. This study was investigate the frequency and types of headaches in individuals with epilepsy, and the impact of headaches on the clinical features and quality of life in this patient group.
Methods: 150 individuals with epilepsy, 83 female and 67 male, were included in the study sample by random sampling method. Headaches were primarily defined as pre-ictal, ictal, and post-ictal headaches according to the temporal relationship with seizures. Headaches that were not temporally related to seizures were defined as inter-ictal headaches. Types and features of participants’ headaches were evaluated using the headache questionnaire consisting of 35 questions. Individuals’ quality of life was evaluated using the Quality of Life in Epilepsy Inventory (QOLIE-10).
Results: Of the 150 participants included in the study, 73.33% had generalized, 20% focal, and 6.66% combined generalized focal epilepsy, and 41.33% had accompanying headache complaints. Of the participants with headaches, 35.48% were male and 64.51% were female. Inter-ictal headache, which was detected in 72.58% participants, was the most common type of headache. Tension and migrainous type headaches were more common among participants with inter-ictal headache, whereas migrainous type headaches were more common among participants with pre- and post-ictal headaches. There were statistically significant differences in the scores obtained from all three subscales of QOLIE-10 inventory between the participants with and without headache. Accordingly, quality of life was worse in the headache group than in the headache-free group (p
Ultrasonic shear-wave elastography: a novel method for assessing the tumor grade in endometrial cancer: a prospective study
Authors: DESTEGÜL Emre , ÇAKIR PEKÖZ Burçak , SEYFETTİNOĞLU Sevtap , BAŞ Sevda , ADIGÜZEL Fikriye Işıl , NARİN Mehmet 
Published: October 2023

Aims: To evaluate the diagnostic performance of the real time shear-wave elastography in patients with endometrial cancer in terms of tumor grade and myometrial invasion depth preoperatively.
Methods: In this prospective observational study, forty-eight women who were diagnosed with endometrioid type endometrium cancer in our gynecologic oncology clinic of a tertiary hospital between September 2020-January 2021 in Turkey. All patients underwent an ultrasonographic shear-wave measurements. Mean shear-wave values were measured from the tumor itself. Mean elasticity values were assessed in terms of tumor grade and myometrial invasion depth.
Results: The median [%25-%75] shearwave value of the participants was 29.45kPa (5.02-167.21). Shear-wave value for grade 3 endometrial cancer showed a statistically significant difference compared to grade 1 and 2 shear-wave values (p0.05). ROC curve analysis showed significant results to determine the myometrial invasion depth and grade 3 endometrial cancer with the mean shear-wave cut-off values of 28.29 kPa and 57 kPa respectively (p
Quality analysis of YouTube videos in the management of hyperlipidemia in adults
Authors: TAŞTEMUR Mercan , MORDAĞ ÇİÇEK Ceren 
Published: October 2023

Aims: We aimed to evaluate the quality of video content about hyperlipidemia and its treatment on YouTube which is used as an information source.
Methods: This study has a cross-sectional design. A hundred videos were reviewed. Journal of the American Medical Association (JAMA) score, Global quality score (GQS), modified DISCERN and Hyperlipidemia YouTube Score (HYS) were used for the quality analysis of the videos. Video duration (minutes), time since upload (months), Number of views/comments/likes were analyzed.
Results: GQS was 1.58±0.94 for Turkish videos and 2.28±1.21 for English videos (p
Comparative analysis of laparoscopic inguinal hernia surgical training videos on WebSurg vs YouTube platforms: a quality evaluation
Authors: ERTEKİN Süleyman Çağlar 
Published: October 2023

Aims: Minimally invasive surgical techniques, particularly laparoscopic methods for inguinal hernia repair, have gained popularity due to their benefits such as reduced postoperative pain and faster recovery. This study aimed to compare the educational quality of laparoscopic inguinal hernia surgical training videos between YouTube and WebSurg platforms.
Methods: Using the keyword “laparoscopic inguinal hernia” we selected and analyzed top 20 videos based on popularity on both platforms. The study examined video sources, duration, likes, views, upload year, coverage of the entire surgical procedure, and evaluation scores (Global Quality Scale-GQS, American Medical Association-JAMA scores, modified DISCERN score, LAP-VEGaS criteria).
Results: YouTube predominantly featured private hospitals/organizations (30%) and physicians (45%), while WebSurg showcased academic institutions (75%). Notably, YouTube hosted mostly edited/abbreviated videos (95%), whereas WebSurg presented a balanced distribution of full-length (50%) and edited/abbreviated (50%) videos. While engagement metrics were comparable, WebSurg consistently achieved higher evaluation scores across various criteria, including modified DISCERN, GQS, JAMA, and LAP-VEGaS (p
Evolution of Views on the Socio-Economic Role of Information Technology – the Example of the 60-Year History of Central Economics and Mathematics Institute of Russian Academy of Sciences
Authors: Ilmensky Mikhail D. , Parinov Sergey I. 
Published: October 2023

The history of the information technology (IT) development at CEMI RAS and the rethinking of the IT role and associated expectations that has occurred over 60 years in this organization can be an illustration of the evolution of views in the scientific community regarding the socio-economic potential of IT. Over the years of its research work, CEMI RAS worked out the most effective way to use almost all major modifications of computers in scientific research, and also carried out the work related to the development of information and communication technologies, including the Internet. Gradually, views on the IT role as a tool for scientific research evolved into an understanding of the complex impact of IT on socio-economic processes, which has the form of widespread digitalization of socio-economic activities. Under these conditions, one of the key IT-related areas of research and development is the creation of a concept for digitalization of coordination mechanisms, the improvement of which affects the entire socio-economic system. The proposed study briefly presents the main milestones in the use and development of IT over the 60 years of CEMI existence and substantiates a qualitatively new task of using and developing IT to improve methods for coordinating scientific research. The rationale for this task is presented using the example of research activities, but the overall long-term goal of these studies is to develop the concept of digital infrastructure and corresponding institutional structures that will ensure better coordination and act as catalyst for the country's development in all major areas of economic activity.
PENGARUH MODEL PEMBELAJARAN MIND MAPPING BERBANTUAN MEDIA POWER POINT TERHADAP HASIL BELAJAR
Authors: Gozali Imam , Panglipur Indah Rahayu , Putra Eric Dwi 
Published: October 2023

Students' mathematical learning results are influenced by many variables, including students, parents, schools, curricula, and mathematics itself. Preliminary observations showed that 27.7% of students received a score above 75 and 72.3% received a rating below 75. The minimum score for the exam was 75, which is the average grade. Many factors can contribute to poor student learning outcomes, including the role of teachers as instructors and their influence on students in creating and using inappropriate learning strategies. An alternative that can be developed on a model with learning is to use a mind mapping defence model. This survey aims to find out how much influence it has found on the mind mapping defense model with the help of power points. The type of quantitative research used in this study is the design of a single group pretest-posttest. The test results are known to have a thitung value of 3.27. Thitung values are matched to with Table values with a significant upgrade of a=0,05 and obtained Table Values of 2.063. Thitung Values are derived that is greater than Table Value (thitung = 3.27 > ttable = 2.063 then Ha is accepted, that is, using the learning model of Mind Mapping and PowerPoint media, the student's learning results can be influenced.
Genome-scale metabolic models consistently predict in vitro characteristics of Corynebacterium striatum
Authors: Bäuerle Famke , Döbel Gwendolyn O. , Camus Laura , Heilbronner Simon , Dräger Andreas 
Published: October 2023

Introduction: Genome-scale metabolic models (GEMs) are organism-specific knowledge bases which can be used to unravel pathogenicity or improve production of specific metabolites in biotechnology applications. However, the validity of predictions for bacterial proliferation in in vitro settings is hardly investigated.Methods: The present work combines in silico and in vitro approaches to create and curate strain-specific genome-scale metabolic models of Corynebacterium striatum.Results: We introduce five newly created strain-specific genome-scale metabolic models (GEMs) of high quality, satisfying all contemporary standards and requirements. All these models have been benchmarked using the community standard test suite Metabolic Model Testing (MEMOTE) and were validated by laboratory experiments. For the curation of those models, the software infrastructure refineGEMs was developed to work on these models in parallel and to comply with the quality standards for GEMs. The model predictions were confirmed by experimental data and a new comparison metric based on the doubling time was developed to quantify bacterial growth.Discussion: Future modeling projects can rely on the proposed software, which is independent of specific environmental conditions. The validation approach based on the growth rate calculation is now accessible and closely aligned with biological questions. The curated models are freely available via BioModels and a GitHub repository and can be used. The open-source software refineGEMs is available from https://github.com/draeger-lab/refinegems.
Simultaneous immobilization of lead, cadmium and arsenic in soil by iron-manganese modified biochar
Authors: Yang Zhihui , Zeng Gai , Liu Lin , He Fangshu , Arinzechi Chukwuma , Liao Qi , Yang Weichun , Si Mengying 
Published: October 2023

Cationic lead/cadmium and anionic arsenic exhibit opposite geochemical behaviors in soils, which makes the synchronous remediation of As, Cd, and Pb challenging. In this study, we developed an iron-manganese modified biochar (BC-Fe-Mn) that prepared from straw with iron (Fe) and manganese (Mn) loading at a pyrolysis temperature of 550 °C. After BC-Fe-Mn immobilization for 90 days, the simultaneous immobilization efficiency of Pb, Cd, and As reached 57%, 51%, and 35%, respectively. Speciation distributions shows that As transformed from specific bound state into weakly low crystallinity iron bound state. Cd transformed from carbonate fraction into Fe-Mn oxide bound fraction, and Pb transformed from carbonate fraction into residual state. During the procedure, simultaneous immobilization mechanisms might involve heavy metal morphological transformation, precipitation/co-precipitation, and surface complexation. Cd and Pb absorbed onto BC-Fe-Mn. Then the increased free iron oxides (Fed) reacted with the dissolved As to form iron-arsenic precipitation. The results show that BC-Fe-Mn is a promising material for the simultaneous immobilization of Pb, Cd, and As in multi-metal contaminated soil.
CD14highCD16+ monocytes are the main producers of Interleukin-10 following clinical heart transplantation
Authors: Ludwig Kristina , Chichelnitskiy Evgeny , Kühne Jenny F. , Wiegmann Bettina , Iske Jasper , Ledwoch Nadine , Ius Fabio , Beushausen Kerstin , Keil Jana , Iordanidis Susanne , Rojas Sebastian V. , Salman Jawad , Knoefel Ann-Kathrin , Haverich Axel , Warnecke Gregor , Falk Christine S. 
Published: October 2023

IntroductionFollowing heart transplantation, a cascade of immunological responses is initiated influencing the clinical outcome and long-term survival of the transplanted patients. The anti-inflammatory cytokine interleukin-10 (IL-10) was shown to be elevated in the blood of heart transplant recipients directly after transplantation but the releasing cell populations and the composition of lymphocyte subsets following transplantation have not been thoroughly studied.MethodsWe identified immune cells by immunophenotyping and analyzed intracellular IL-10 production in peripheral blood mononuclear cells (PBMC) of heart transplanted patients (n= 17) before, directly after and 24h post heart transplantation. The cells were stimulated with lipopolysaccharide or PMA/Ionomycin to enhance cytokine production within leukocytes in vitro.Results and discussionWe demonstrate that intermediate monocytes (CD14highCD16+), but not CD8+ T cells, CD4+ T cells, CD56+ NK cells or CD20+ B cells appeared to be the major IL-10 producers within patients PBMC following heart transplantation. Consequently, the absolute monocyte count and the ratio of intermediate monocytes to classical monocytes (CD14+CD16-) were specifically increased in comparison to pre transplant levels. Hence, this population of monocytes, which has not been in the focus of heart transplantation so far, may be an important modulator of clinical outcome and long-term survival of heart transplant recipients. Alteration of blood-circulating monocytes towards a CD14highCD16+ phenotype could therefore shift the pro-inflammatory immune response towards induction of graft tolerance, and may pave the way for the optimization of immunosuppression.
Intraocular lens power calculation for silicone oil-dependent eyes
Authors: Wang Leyi , Wang Xin , Yang Xuepeng , Si Yuanyuan , Wu Jiayin , Cui Yan 
Published: October 2023

BackgroundSilicone oil tamponade is widely used in vitreoretinal surgery. In some cases, silicone oil may not be extracted for a long time or even permanently and is referred to as silicone oil-dependent eyes. In this study, we aimed to deduce a theoretical formula for calculating intraocular lens power for silicone oil-dependent eyes and compare it with clinical findings.MethodsA theoretical formula was deduced using strict geometric optical principles and the Gullstrand simplified eye model. The preoperative and postoperative refractive statuses of patients with silicone oil-dependent eyes who underwent intraocular lens implantation were studied (Group A, n = 13). To further test our derived theoretical formula, patients with silicone oil tamponade and first-stage intraocular lens implantation were included (Group B, n = 19). In total, 32 patients (32 eyes) were included in the study.ResultsIn group A, the calculated intraocular lens power based on our formula was 24.96 ± 3.29 diopters (D), and the actual refraction of the patients was 24.02 ± 4.14D. In group B, the theoretical intraocular lens power was 23.10 ± 3.08D, and the clinical intraocular lens power was 22.84 ± 3.42D. There was no significant difference between the theoretical and clinical refractive powers, and the intraclass correlation coefficient was 0.771 for group A and 0.811 for group B (both p ≤ 0.001). The mean absolute error for silicone oil-dependent eyes of the formula was 1.66 ± 2.09D. After excluding data for two patients with a flat cornea (corneal refractive power &lt; 42D), the mean absolute error decreased to 0.83 ± 0.62D.ConclusionA strong correlation between the theoretical and clinical intraocular lens powers was observed, and the formula we deduced can be used to calculate the intraocular lens power for silicone oil-dependent eyes. This formula will help clinicians select a more appropriate intraocular lens for patients with silicone oil-dependent eyes, especially when the corneal refractive power is ≥42D.
Machine learning-based radiomics to differentiate immune-mediated necrotizing myopathy from limb-girdle muscular dystrophy R2 using MRI
Authors: Wei Ping , Zhong Huahua , Xie Qian , Li Jin , Luo Sushan , Guan Xueni , Liang Zonghui , Yue Dongyue 
Published: October 2023

ObjectivesThis study aimed to assess the feasibility of a machine learning-based radiomics tools to discriminate between Limb-girdle muscular dystrophy R2 (LGMDR2) and immune-mediated necrotizing myopathy (IMNM) using lower-limb muscle magnetic resonance imaging (MRI) examination.MethodsAfter institutional review board approval, 30 patients with genetically proven LGMDR2 (12 females; age, 34.0 ± 11.3) and 45 patients with IMNM (28 females; age, 49.2 ± 16.6) who underwent lower-limb MRI examination including T1-weighted and interactive decomposition water and fat with echos asymmetric and least-squares estimation (IDEAL) sequences between July 2014 and August 2022 were included. Radiomics features of muscles were obtained, and four machine learning algorithms were conducted to select the optimal radiomics classifier for differential diagnosis. This selected algorithm was performed to construct the T1-weighted (TM), water-only (WM), or the combined model (CM) for calf-only, thigh-only, or the calf and thigh MR images, respectively. And their diagnostic performance was studied using area under the curve (AUC) and compared to the semi-quantitative model constructed by the modified Mercuri scale of calf and thigh muscles scored by two radiologists specialized in musculoskeletal imaging.ResultsThe logistic regression (LR) model was the optimal radiomics model. The performance of the WM and CM for thigh-only images (AUC 0.893, 0.913) was better than those for calf-only images (AUC 0.846, 0.880) except the TM. For “calf + thigh” images, the TM, WM, and CM models always performed best (AUC 0.953, 0.907, 0.953) with excellent accuracy (92.0, 84.0, 88.0%). The AUCs of the Mercuri model of the calf, thigh, and “calf + thigh” images were 0.847, 0.900, and 0.953 with accuracy (84.0, 84.0, 88.0%).ConclusionMachine learning-based radiomics models can differentiate LGMDR2 from IMNM, performing better than visual assessment. The model built by combining calf and thigh images presents excellent diagnostic efficiency.
Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson’s disease and hypophonia
Authors: Manes Jordan L. , Kurani Ajay S. , Herschel Ellen , Roberts Angela C. , Tjaden Kris , Parrish Todd , Corcos Daniel M. 
Published: October 2023

IntroductionHypophonia is a common feature of Parkinson’s disease (PD); however, the contribution of motor cortical activity to reduced phonatory scaling in PD is still not clear.MethodsIn this study, we employed a sustained vowel production task during functional magnetic resonance imaging to compare brain activity between individuals with PD and hypophonia and an older healthy control (OHC) group.ResultsWhen comparing vowel production versus rest, the PD group showed fewer regions with significant BOLD activity compared to OHCs. Within the motor cortices, both OHC and PD groups showed bilateral activation of the laryngeal/phonatory area (LPA) of the primary motor cortex as well as activation of the supplementary motor area. The OHC group also recruited additional activity in the bilateral trunk motor area and right dorsal premotor cortex (PMd). A voxel-wise comparison of PD and HC groups showed that activity in right PMd was significantly lower in the PD group compared to OHC (p &lt; 0.001, uncorrected). Right PMd activity was positively correlated with maximum phonation time in the PD group and negatively correlated with perceptual severity ratings of loudness and pitch.DiscussionOur findings suggest that hypoactivation of PMd may be associated with abnormal phonatory control in PD.