bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of meat sold for human consumption in Benue State, Nigeria for antibiotic residues
Authors: Onminyi N.O. , Agada C.A. , Luga I.I. , Ofukwu R.A. , Onyeyeli P.A. 
Published: February 2024

The problem of veterinary drug residues in food of animal origin is of great importance in developing countries. The concerns are mostly related to food safety and the development of antibiotic-resistant pathogens. This study was carried out during the hot dry season (March) between 2016 – 2018 to detect antibiotic presence in beef, chevon and pork sold for human consumption in abattoirs in Benue state. Thirty-nine samples each of 100-150g of kidney, liver and muscle were collected from cattle, goats and pigs making a total of 351 samples from abattoirs across the three geopolitical zones of Benue state. The samples were screened for multidrug residues using the modified agar gel diffusion method. A total of 144 were positive out of which 40.3% (58/144) were beef, while 29.2% (42/144) and 30.5% (44/144) were chevon and pork respectively. From the results of this study, it could be inferred that the meat consumed within Benue State contains residues of antibiotics possibly because of non-adherence to the withdrawal period by farmers and lack of knowledge of its consequences on the consumers.
Venetoclax in combination with azacitidine or decitabine in relapsed/refractory acute myeloid leukemia
Authors: Che Yue , Tan Wanqing , Liu Ying , Liu Haitao , Li Lanlan , Qin Fangmei 
Published: February 2024

Purpose: To investigate the clinical effects of venetoclax combined with azacitidine or decitabine in relapsed/refractory acute myeloid leukemia.
Methods: 208 eligible first-line participants, who were diagnosed and treated for relapsed/refractory acute myeloid leukemia between January 2022 and December 2022, were recruited from the Department of Hematology of Loudi Central Hospital, China. The patients were randomly divided into study and control groups at the point of recruitment. Patients in the control group received venetoclax combined with decitabine, while those in the study group received venetoclax in combination with azacitidine. Clinical data for the two groups were recorded. The primary endpoints of this study included efficacy, routine blood indices, and adverse reactions.
Results: There was no statistically significant difference in baseline characteristics between the two groups (p > 0.05), indicating comparability. The total effectiveness of the treatment (i.e., efficacy) in the study group was higher than in the control group (p < 0.05), while the control group had a higher risk of platelet, red blood cell, and neutrophil absolute count reduction than the study group (p < 0.05). The platelet count and hemoglobin level were lower in the control group after treatment compared to the study group (p < 0.05).
Conclusion: The combination of venetoclax with azacitidine improves the efficacy and blood routine indices of patients with relapsed/ refractory acute myeloid leukemia, while reducing adverse reactions.
Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment
Authors: Hu Wei , Ma Wenzhe , Li Bo , Hou Yu , Dai Rongyang 
Published: February 2024

Glycyrrhiza flavonoids (GF) are essential antitumor components of Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata roots and tubers, with antioxidant, anti-inflammatory, antibacterial, immune-enhancing amongst other properties. In recent years, significant progress has been made in understanding the mechanisms and targets of GF in various pharmacological settings. This review summarizes the clinical value, targets and research progress of the molecular mechanisms underlying GF in the treatment of malignant tumors. This will provide as a theoretical foundation for further studies into GF as a therapeutic option in the management of cancerous tumors.
MiR-128-3p inhibits the proliferation, migration and invasion of human nasopharyngeal carcinoma cells via EMT
Authors: Li Jingli , Wang Hui 
Published: February 2024

Purpose: To investigate the effect of overexpressing miR-128-3p on the migration, invasion, and proliferation of human nasopharyngeal cancer cells, and associated pathways.Methods: Cell counting kit-8 (CCK-8) and clone creation tests were used to investigate the effect of miR-128-3p inhibitor on the growth of C666-1 cells. The inhibitor control and miR-128-3p inhibitor were transfected into human nasopharyngeal cancer cells (C666-1) and allowed to incubate for 48 h. Cell migration and invasion assays were conducted using Transwell and Scratch assays. Cell cycle was assessed using propidium iodide (PI) single-staining method, while expression of miR-128-3p was evaluated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Expression levels of vimentin, E-cadherin, and N-cadherin were determined by Western blot.Results: MiR-128-3p inhibitor transfection in C666-1 cells significantly increased cell proliferation, cell viability, and clonal proliferation, and also significantly reduced miR-128-3p expression levels, and enhanced cell migration and invasion. In C666-1 cells, inhibition of miR-128-3p induced epithelial mesenchymal transition (EMT).Conclusion: MiR-128-3p inhibits nasopharyngeal cancer cells from proliferating, migrating, and invading by regulating epithelial mesenchymal transition. MiR-128-3p may therefore be a viable therapeutic target for nasopharyngeal cancer. Future studies are required to yield pertinent data in support of this hypothesis.
Small molecule inhibitor azd1480 reverses radiotherapy resistance in NSCLC by targeting JAK2/STAT3 pathway
Authors: Mao Ying , Yao Yang , Liu Li 
Published: February 2024

Purpose: To investigate the effect of small molecule inhibitor AZD1480 on radiotherapy resistance in non-small cell lung cancer (NSCLC), and the involvement of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in the process.
Methods: Radiation-resistant cell lines A549-20F, A549-30F, A549-40F and H460, H46040F, H460- 40F, and H460-40F were established, and expressions of proteins related to JAK/STAT pathway, mitogen-activated protein (MAPK) pathway and transforming growth factor-β (TGF- β) were assayed. The JAK2V617FH460 overexpression cell line and JAK2H460 cell line were established, and expressions of ATGL and CPT1A were compared. The H460 cells and H460-40F cells were treated with JAK2 small molecule inhibitor AZD1480, and the expressions of ATGL, CPT1A and JAK2/STAT3 pathway-related proteins were compared. The survival and proliferation of cell lines were also compared.
Results: The JAK/STAT pathway was significantly enriched, and MAPK and TGF-β were up-regulated. In H460 cells, JAK2/STAT3 route was obvious, suggesting that radiotherapy activated JAK2/STAT3 pathway in NSCLC cells. Significant down-regulations of p- JAK2Y1007, JAK2, p-STAT3s727, STAT3, ATGL and CPT1A proteins expressions were seen in H460 + AZD1480 group, relative to H460 group, but protein levels of p-JAK2Y1007, JAK2, p-STAT3s727, STAT3, ATGL and CPT1A were significantly lower in H460-40F + AZD1480 group than in H460-40F group (p < 0.05). The survival and proliferation rates were significantly lower in A549 + AZD1480 group than in A549 and A549-40F groups (p < 0.05).
Conclusion: Radiotherapy up-regulates the expressions of ATGL and CPT1A in NSCLC cells by activating the JAK2/STAT3 pathway, while AZD1480, a small molecule inhibitor, reverses the radiation resistance of NSCLC by targeting JAK2/STAT3 pathway and key enzymes of lipid metabolism. Therefore, azd1480 may enhance clinical treatment efficacy in NSCLC patients by reducing radiation resistance.
Anti-parkinsonian, anti-inflammatory, anti-microbial, analgesic, anti-hyperglycemic and anticancer activities of poly-fused ring pyrimidine derivatives
Authors: Bafail Rawan S.M. , Samman Waad A. 
Published: February 2024

Purpose: To investigate the anti-inflammatory, anti-cancer, anti-parkinsonian, anti-microbial, analgesic, and anti-hyperglycemic properties of a variety of poly-fused pyrimidine derivatives.
Methods: A novel series of fused pyrimidine derivatives 1-6 were synthesized by reacting amino pyrazole derivatives with active methylene derivatives to give the corresponding compounds 1-6. Anti-parkinsonian activity was investigated with benzotropene as a reference drug, anti-inflammatory effect in mice was evaluated using carrageenan in paw edema with indomethacin as reference drug, anti-microbial activity was assessed using nutritional agar with ciprofloxacin and ketoconazole as reference drugs, analgesic activity was evaluated using valdecoxib as reference drug, anti-hyperglycemic activity was investigated using alloxan and sucrose models (SLM) with pioglitazone as reference drug and anticancer activity was investigated using the MTT micro-cultured tetrazolium assay method with doxorubicin as reference drug.
Results: Pyrimidine derivatives 1-6 possess significant active anti-parkinsonian, anti-inflammatory, anti-microbial, analgesic, anti-hyperglycemic and anticancer activities in comparison to the reference drugs used for each model. Compared to Benzotropene®, compounds 1 and 3 showed a significantly stronger anti-parkinsonian activity (p < 0.03). Compound 3 showed a significantly stronger anti-inflammatory effect than Indomethacin® (p < 0.05). Compounds 5 and 6 exhibited significant anti- microbial activity compared to ciprofloxacin® (p < 0.05). Compounds 4 and 6 exhibited significantly improved analgesic activity as compared to Valdecoxib® (p < 0.01). Compounds 1 and 3 exhibited significantly higher anti-hyperglycemic effects in SLM model when compared to pioglitazone® (p < 0.02). Compound 5 demonstrated the highest activity against human colon cancer cell line (HT-29) and human prostate cancer cell line (DU145), and also, significantly improved level of efficacy against human lung cancer cell line (A549) compared to Doxorubicin® (p < 0.02).
Conclusion: Using the six pyrimidine derivatives 1 - 6 as a lead molecule, a novel class of clinically beneficial anti-cancer, anti-inflammatory, anti-microbial, analgesic, and anti-hyperglycemic drugs may be produced.
Examining Digital Divide in Secondary and Primary Education Online Content Users Based in Tanzania
Authors: Wazoel Lubua Edison 
Published: February 2024

This paper determined the digital divide among secondary and primary education online platforms in Tanzania. The study addressed three key aspects: first, it determined the contribution of facilitating conditions in the digital divide among secondary and primary school learners. Secondly, it determined how the quality of existing secondary and primary education digital platforms defines the current status of the digital divide. Lastly, the study provides steps to be taken by stakeholders of education in addressing the digital divide in the context of secondary and primary education. The study used the qualitative approach. First, it used government reports and other organisational publications to obtain statistical information on facilitating conditions for educational digital services. Secondly, it studied 302 online reviews by users of seven (7) digital platforms for secondary and primary education contents in Tanzania. In the first set of results facilitating conditions such as ownership of smartphones, computers, Televisions, and access to the Internet still contribute to the digital divide among users of secondary and primary education platforms. In the second set of reviews, the study observed the following nature of reviews submitted by users to studied online platforms. The first category had a positive view of digital platforms. This is a positive view submitted to the platform on its usefulness. In all platforms, users were of the view that the platforms were useful. Another category was that of poor technical quality. This view reflects the perception of viewers that the quality of the accessed platform was poor. In this category, users were more uncomfortable with the inability of the platform to launch appropriately. The third category was about the quality of the contents. In all platforms, users suggested that the contents were inadequate. With the guidance of policies, all stakeholders need to engage together in addressing observed issues of the digital divide.
PAI Teachers' Creativity in Utilizing Digital-Based Learning Media
Authors: Reksiana Reksiana , Humaeroh Sayyidah 
Published: February 2024

The research raises the issue of the rise of teachers who do not have the power of creativity in the era of digitalization of education. This study aims to analyze the development of creativity of PAI teachers at SMK Miftahul Falah Jakarta in utilizing information technology-based learning media. The research method used in this study is a qualitative method with a descriptive approach. The object of this research is SMK Miftahul Falah Jakarta. The primary data sources of this study are 1 PAI teacher, 1 student and 1 student. While secondary data in the form of books, journals and articles, and documentation sources of learning activities in the classroom, learning media used, and school profiles. Data collection techniques are through observation, interview and documentation methods. The data analysis technique uses Miles and Huberman data analysis with three stages, namely data reduction, data presentation, withdrawal. The findings in the study are that the development of digital-based media creativity carried out by PAI teachers at SMK Miftahul Falah Jakarta has an impact on four aspects. First, the aspect of fluency of thinking is seen from the learning steps carried out. Both aspects of flexibility of thinking are seen from the creation of information technology-based learning media and motivation. The three aspects of originality are seen from trainings on the use of information technology-based learning media. The four aspects of elaboration (elaboration) are seen from the creativity of PAI teachers in developing the potential of students through the use of information technology-based learning media. Another finding is that if PAI teachers use ICT-based learning media, it will have an impact on increasing the motivation and enthusiasm of students in learning PAI.
RELATIONSHIP BETWEEN MOROCCAN CPGE STUDENTS MOTIVATION AND CRITICAL THINKING
Authors: Chana Si Mohamed 
Published: February 2024

Critical thinking is gaining momentum in the digital era, particularly with the propagation of social media. Improving students' cognitive abilities is not just meant to have easy access to the job market, but to be equipped in the time of misinformation and fake news. However, effective enhancement of this cognitive skill in students requires motivation as an important ingredient; without motivation for critical thinking learning, teachers will fail in their attempts to improve their students' thinking skills. This article is an empirical study on the importance of motivation for critical thinking for CPGE students and its relationship with the students' levels of critical thinking. 120 CPGE students, both male and female, were involved in this study. As the study is experimental, the students were divided into two groups: experimental and control groups. The results of the data analysis revealed that the treatment groups outscored the control group students in the motivation for critical thinking learning; the data also showed a positive correlation between the treatment group's motivation for critical thinking and their level of critical thinking.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0605/a.php" alt="Hit counter" /></p>
DÉTERMINANTS DE L’APPROPRIATION DU NUMÉRIQUE PÉDAGOGIQUE ET PRATIQUES ENSEIGNANTES AU CAMEROUN : CAS DE CERTAINS ENSEIGNANTS DU SECONDAIRE PUBLIC / DETERMINANTS OF THE APPROPRIATION OF DIGITAL EDUCATION AND TEACHING PRACTICES IN CAMEROON: CASE OF CERTAIN PUBLIC SECONDARY TEACHERS
Authors: Nana Aicha , Banen John Thierry 
Published: February 2024

<p>La récente crise sanitaire a poussé le système éducatif camerounais à entrer davantage dans l'ère du numérique comme outil et moyen de continuité pédagogique. Dans le même temps, elle a mis en exergue les dysfonctionnements liés à l'applicabilité du numérique dans le secteur de l'enseignement secondaire. L'objectif de cette recherche est d'analyser la corrélation entre certains déterminants de l'appropriation de la pédagogie numérique et les pratiques pédagogiques des enseignants du secondaire dans la ville de Yaoundé, au Cameroun. Les résultats obtenus auprès de 280 participants ciblés indiquent que la faible utilisation, le manque de maîtrise et l'inaccessibilité du numérique constituent de véritables obstacles aux pratiques pédagogiques. Il est donc nécessaire d'aménager le dispositif pédagogique numérique, indispensable à l'efficacité et à la résilience de l'enseignement secondaire au Cameroun.</p><p>The recent health crisis has pushed Cameroon's education system further into the digital age as a tool and means of pedagogical continuity. At the same time, this has highlighted the dysfunctions associated with the applicability of digital technology in the secondary education sector. The aim of this research is to analyze the correlation between certain determinants of the appropriation of digital pedagogy and the teaching practices of secondary school teachers in the city of Yaoundé, Cameroon. The results obtained from 280 targeted participants indicate that the low use, lack of mastery and inaccessibility of digital technology are real obstacles to teaching practices. It is therefore necessary to adapt the digital teaching system, which is essential for the effectiveness and resilience of secondary education in Cameroon.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0014/a.php" alt="Hit counter" /></p>
Survey for Carbapenem Resistant Klebsiella Pneumoniae among Patients Attending Aminu Kano Teaching Hospital, Kano, Nigeria
Authors: Muhammad Binta Aminu 
Published: February 2024

Carbapenem resistant Klebsiella pneumoniae is becoming a more significant pathogen because of the grave clinical risk it poses which affects patient’s treatment outcome. This study aimed to survey for carbapenem resistant Klebsiella pneumoniae (CRKP) among patients attending Aminu Kano Teaching Hospital, Kano State, Nigeria. A total of 600 clinical samples including urine, sputum and swabs were collected and screened. Klebsiella pneumoniae were isolated and confirmed using culture, microscopy and biochemical test according to standard microbiological techniques. Phenotypic carbapenem resistant and carbapenemase production were detected using meropenem discs diffusion method and modified Hodge test respectively. Genotypic carbapenemase productions were confirmed by detecting the presence of blaKPC genes using PCR and Gel electrophoresis. Antibiotics susceptibility profiles of the CRKP isolates were evaluated using disc diffusion method and interpreted using CLSI protocols. The study revealed the incidence of Klebsiella pneumoniae infection as 14% with the highest occurrence in sputum (18%) and the lowest in swab (10%). Of the total number of isolated K. pneumoniae, 14.3% were found to be carbapenem resistant. Up to 75% of CRKP isolates were found to produce carbapenamase and harbor blaKPC genes. Antibiotic susceptibility profile of these isolates revealed colistin and tigecycline as the most active antibiotics in vitro (92%).The isolates were found to be generally resistant to cefepime, ceftriaxone, cefuroxime, cotrimoxazole and ciproflaxin (100%). Up to 8% of the isolates were sensitive to Gentamicin and Nalidixic acid, 25% to Nitrofurantoin, 50% to Minocycline and 17% to Amikacin. This study verifies the existence of carbapenem resistant Klebsiella pneumoniae isolates that are highly resistant to other antibiotics in patients attending AKTH Kano which is an indication of increase in drug resistance. This requires the need for newer tactics in infection control to prevent the spread of carbapenem resistant isolates.
Risk modeling and making relevant management decisions when choosing a construction service provider
Authors: Гуреев К.А. , Наговицын А.А. 
Published: February 2024

Научная статья посвящена моделированию рисков и принятию релевантных управленческих решений при выборе поставщика строительных услуг. Представлена оценка основных критериев при выборе поставщика строительных услуг различными методами, такими как «метод сумм» и «метод средний арифметический». Сравнены критерии по их значимости. При принятии управленческих решений и моделировании рисков применялся программный продукт «Decon на базе MS Excel». Перспективы своих исследований авторы связывают с изучением линейных и матричных моделей оценки рисков строительных работ.
The scientific article is devoted to risk modeling and making relevant management decisions when choosing a construction service provider. An assessment of the main criteria for choosing a construction service provider using various methods such as the "sum method" and the "arithmetic mean method" is presented. The criteria are compared according to their significance. When making management decisions and modeling risks, the software product "Decon based on MS Excel" was used. The authors associate the prospects of their research with the study of linear and matrix models for assessing the risks of construction work.
Miedos y olores. Emociones y sentidos en una cárcel de varones
Authors: Guzmán Ramírez Gezabel 
Published: February 2024

El miedo es inherente a nuestra naturaleza humana. Sin embargo, para Zygmunt Bauman (2008) existen tres peligros que lo acrecientan: 1) los que amenazan el cuerpo; 2) los que amenazan el orden social, y 3) los que afectan el lugar de la persona. En este artículo se abordan algunas amenazas al cuerpo que propician el miedo en un escenario en particular: la cárcel.
Para ello, se empleó el método cualitativo de historias de vida a través de entrevistas abiertas, en las cuales se rescata la narrativa de Raúl, Alberto y Manuel, quienes estuvieron privados de su libertad en una prisión de la Ciudad de México. La experiencia narrada está enmarcada por sentidos como el olfato que acompañan lo vivido en la cárcel.
La apuesta metodológica está orientada desde la antropología de las emociones y de los sentidos a partir de las siguientes preguntas: ¿qué amenazas al cuerpo se experimentan en prisión?, ¿a qué se le teme al estar privado de la libertad?, y ¿qué relación existe entre el miedo y el olfato en un ámbito carcelario?
Las respuestas versan en torno a la enfermedad y su olor, el miedo al contagio y la presencia de plagas, así como el miedo al olvido, el “olor a cárcel” y el miedo constante de morir en reclusión.