bluuebunny/crossref_metadata_2025_split huggingface dataset:
The applied principles of EEG analysis methods in neuroscience and clinical neurology
Authors: Zhang Hao , Zhou Qing-Qi , Chen He , Hu Xiao-Qing , Li Wei-Guang , Bai Yang , Han Jun-Xia , Wang Yao , Liang Zhen-Hu , Chen Dan , Cong Feng-Yu , Yan Jia-Qing , Li Xiao-Li 
Published: December 2023

AbstractElectroencephalography (EEG) is a non-invasive measurement method for brain activity. Due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals, EEG has aroused much interest in scientific research and medical fields. This article reviews the types of EEG signals, multiple EEG signal analysis methods, and the application of relevant methods in the neuroscience field and for diagnosing neurological diseases. First, three types of EEG signals, including time-invariant EEG, accurate event-related EEG, and random event-related EEG, are introduced. Second, five main directions for the methods of EEG analysis, including power spectrum analysis, time–frequency analysis, connectivity analysis, source localization methods, and machine learning methods, are described in the main section, along with different sub-methods and effect evaluations for solving the same problem. Finally, the application scenarios of different EEG analysis methods are emphasized, and the advantages and disadvantages of similar methods are distinguished. This article is expected to assist researchers in selecting suitable EEG analysis methods based on their research objectives, provide references for subsequent research, and summarize current issues and prospects for the future.
Engineering TGF-β inhibitor-encapsulated macrophage-inspired multi-functional nanoparticles for combination cancer immunotherapy
Authors: Kim Jaehyun , Kim Minjeong , Yong Seok-Beom , Han Heesoo , Kang Seyoung , Lahiji Shayan Fakhraei , Kim Sangjin , Hong Juhyeong , Seo Yuha , Kim Yong-Hee 
Published: December 2023

Abstract

Background
The emergence of cancer immunotherapies, notably immune checkpoint inhibitors, has revolutionized anti-cancer treatments. These treatments, however, have been reported to be effective in a limited range of cancers and cause immune-related adverse effects. Thus, for a broader applicability and enhanced responsiveness to solid tumor immunotherapy, immunomodulation of the tumor microenvironment is crucial. Transforming growth factor-β (TGF-β) has been implicated in reducing immunotherapy responsiveness by promoting M2-type differentiation of macrophages and facilitating cancer cell metastasis.

Methods

In this study, we developed macrophage membrane-coated nanoparticles loaded with a TGF-βR1 kinase inhibitor, SD-208 (M

ϕ

-SDNP). Inhibitions of M2 macrophage polarization and epithelial-to-mesenchymal transition (EMT) of cancer cells were comprehensively evaluated through in vitro and in vivo experiments. Bio-distribution study and in vivo therapeutic effects of M

ϕ

-SDNP were investigated in orthotopic breast cancer model and intraveneously injected metastasis model.

Results

M

ϕ

-SDNPs effectively inhibited cancer metastasis and converted the immunosuppressive tumor microenvironment (cold tumor) into an immunostimulatory tumor microenvironment (hot tumor), through specific tumor targeting and blockade of M2-type macrophage differentiation. Administration of M

ϕ

-SDNPs considerably augmented the population of cytotoxic T lymphocytes (CTLs) in the tumor tissue, thereby significantly enhancing responsiveness to immune checkpoint inhibitors, which demonstrates a robust anti-cancer effect in conjunction with anti-PD-1 antibodies.

Conclusion

Collectively, responsiveness to immune checkpoint inhibitors was considerably enhanced and a robust anti-cancer effect was demonstrated with the combination treatment of M

ϕ

-SDNPs and anti-PD-1 antibody. This suggests a promising direction for future therapeutic strategies, utilizing bio-inspired nanotechnology to improve the efficacy of cancer immunotherapy.

Graphical Abstract
3D printing for an anterolateral thigh phalloplasty
Authors: Walker Maxwell W. , Kaoutzanis Christodoulos , Jacobson Nicholas M. 
Published: December 2023

Abstract
Background
Phalloplasty procedures are performed to create a phallus, typically as a gender-affirming surgery for treating gender dysphoria. Due to the controversial nature of this specific procedure, more innovation is needed to directly assist surgical teams in this field. As a result, surgeons are left to improvise and adapt tools created for other procedures to improve surgical outcomes. This study developed a patient-specific 3D printed model from segmented computed tomography (CT) scans to accurately represent the relevant vasculature necessary for anterolateral thigh (ALT) flap phalloplasty. The surgical procedure seeks to maintain intact vessels that derive from the descending branch of the lateral circumflex femoral artery, typically found traveling within the intermuscular septum between the rectus femoris and vastus lateralis.

Methods
In this study, we created and printed 3D models of the leg and vasculature using two techniques: (1) a standard segmentation technique with the addition of a reference grid and (2) a bitmap method in which the total CT volume is colorized and printed.

Results
The results gathered included the physician’s view on the model’s accuracy and visualization of relevant anatomy. Bitmap-printed models resulted in a high amount of detail, eliciting surgeons’ undesirable reactions due to the excess of information. The hybrid method produced favorable results, indicating positive feasibility.

Conclusions
This study tested the ability to accurately print a patient-specific 3D model that could represent the vasculature necessary for ALT flap procedures and potentially be used in surgical reference and planning in the future. A surgeon performing phalloplasty procedures discussed their approval of both models and their preference for grid creation and application.
Canine panosteitis and preventive veterinary measures: insights from a case series
Authors: Moreira Luciano de Paulo , Zocatelli Taís Fracalossi , Amaral Camila Barbosa 
Published: December 2023

Abstract
Background
Canine panosteitis is a self-limiting developmental orthopedic disease that, despite its name, causes bone marrow adipocyte degeneration and replacement by fibrous tissue. Pain-related lameness is the main clinical sign in young dogs from predisposed breeds such as German Shepherd. Etiology is unknown, and characteristic radiographic sign is increased medullary opacity of affected bone. This case series describes clinical course, radiographic findings, therapy and vaccination schemes adopted in four non-related German Shepherd dogs affected by panosteitis and attended sequentially at a private veterinary diagnostic center.

Case presentation
Lameness was the unanimous clinical sign, accompanied by increased medullary radiopacity of the affected bone. Prescription medication included analgesic drugs and in two cases, nutraceuticals. Calcium supplement was prescribed for one of the dogs, but it was not administered by the owner. All dogs had full recovery from 2 to 14 days followed drug administration. Despite commonly described features, a high number of vaccine doses per patient, in the first months of age, were an intriguing observation, raising question about vaccination and the immune system influence in triggering such diseases in predisposed dogs.

Conclusions
Although a common disease, panosteitis etiology remains undefined. Under this scenario and the presented cases, further research in order to revise vaccination protocols is advised for panosteitis predisposed breeds such as German Shepherd. Besides, local veterinary clinicians’ unawareness of the disease was evident in many aspects and affected therapeutic prescription although not compromising patient recovery.
Mepiquat chloride priming confers the ability of cotton seed to tolerate salt by promoting ABA-operated GABA signaling control of the ascorbate–glutathione cycle
Authors: Qi Qian , Wang Ning , Ruan Sijia , Muhammad Noor , Zhang Hengheng , Shi Jianbin , Dong Qiang , Xu Qinghua , Song Meizhen , Yan Gentu , Zhang Xiling , Wang Xiangru 
Published: December 2023

Abstract
Background
Ensuring that seeds germinate and emerge normally is a prerequisite for cotton production, esp. in areas with salinized soil. Priming with mepiquat chloride (MC) can promote seed germination and root growth under salt stress, but its mechanism has not been fully elucidated. In this study, physiological and biochemical experiments revealed that MC-priming promotes the tolerance of cotton seeds to salt stress by increasing the ability of antioxidant enzymes related to the ascorbate–glutathione (AsA-GSH) cycle to scavenge reactive oxygen species (ROS).

Results
Results revealed that treatment with inhibitors of abscisic acid (ABA) and γ-aminobutyric acid (GABA) biosynthesis reduced the positive effects of MC-priming. Similarly, MC-priming increased the contents of ABA and GABA under salt stress by stimulating the expression levels of GhNCED2 and GhGAD4 and the activity of calmodulin-binding (CML) glutamate decarboxylase (GAD). Further analysis showed that an inhibitor of ABA synthesis reduced the positive impacts of MC-priming on the content of GABA under salt stress, but the content of ABA was not affected by the GABA synthesis inhibitor. Furthermore, a multi-omics analysis revealed that MC-priming increased the abundance and phosphorylation levels of the proteins related to ABA signaling, CML, and Ca2+ channels/transporters in the MC-primed treatments, which resulted in increased oscillations in Ca2+ in the MC-primed cotton seeds under salt stress.

Conclusion
In summary, these results demonstrate that MC-mediated ABA signaling operates upstream of the GABA synthesis generated by GAD by activating the oscillations of Ca2+ and then enhancing activity of the AsA-GSH cycle, which ensures that cotton seeds are tolerant to salt stress.
Some examples of quasiperiodic tilings obtained with a simple grid method
Authors: Sadoc Jean-François , Impéror-Clerc Marianne 
Published: December 2023

Abstract
A grid method using tiling by fundamental domain of simple bi-dimensional lattices is presented. It refers to a previous work done by Stampfli in 1986 using two grids by regular hexagons, one rotated by

relatively to the other. This leads to a quasiperiodic structure with a twelvefold symmetry made of regular triangles, squares and rhombuses. The tessellation of the plane by the overlap domains of two hexagons, each belonging to one of the two grids is considered. Vertices of the quasiperiodic tiling are the mid-point of the centers of the two overlapping hexagons. Edges of the quasiperiodic tiling are obtained by a Delaunay triangulation of the set of reference points. This method is extended to two other types of quasiperiodic tilings with other fundamental domains. A first example uses two square grids leading to the octagonal Ammann-Beenker quasiperiodic tiling. The second example is also based on the hexagonal lattice, but with grids defined by the lattice fundamental rhombic cell.
Purity
Authors: Derry Margaret 
Published: December 2023

Abstract
This article uses the concept of purity to explore the thinking of purebred animal breeders and that of eugenicists in Britain and North America between 1880 and 1920. It begins with an explanation of why such a study is important and continues with the historical background of purity's role in animal breeding over the nineteenth century and an assessment of the theoretical foundations of Francis Galton's eugenics. The article argues that the shared concern with pedigree keeping, which characterized both purebred breeding and eugenics, made it easy for historians to assume that the two fields were more connected than they actually were. In fact, the basis for purity in animal breeding—namely, inbreeding and marketability—could not migrate to eugenics. Pedigree use in animal breeding (inbreeding, consistency, and marketability) actually had little in common with pedigree use in eugenics (evidence of inheritance via statistical quantification). Unpacking this historic connection between animal breeding and eugenics has significance today for such disciplines as animal breeding itself, genetics, politics, and ethics.
Development and Evaluation of an MRI Artifact-Free Aneurysm Clip
Authors: Senger Sebastian , Fischer Gerrit , Mühl-Benninghaus Ruben , Backens Martin , Reisel Jan René , Fritz Tobias , Brack Alexander , Reith Wolfgang , Oertel Joachim 
Published: December 2023

BACKGROUND AND OBJECTIVES:
The digital subtraction angiography is still the gold standard in the follow-up after aneurysm surgery, although it remains a repeating invasive technique with accumulating X-ray exposure. An alternative magnetic resonance angiography has the disadvantage of metal-related artifacts. A metal-free aneurysm clip could overcome this problem. Recent advances in manufacturing technologies of fiber-reinforced plastics might allow developing a prototype of a metal-free clip.

METHODS:
The prototype was formed out of carbon fiber–reinforced polyetheretherketone (CF-PEEK) in accordance with the standard clip design. In vivo and in vitro studies were performed to analyze the central nervous system biocompatibility. The prototype was tested in a phantom in a 3 T MRI scanner and microtomography scanner. For in vivo assessment, the left renal artery of rats was either ligated with a suture, clipped with a regular titanium clip or with the CF-PEEK prototype clip. The animals underwent standard MRI sequences and magnetic resonance angiography and assessment by a blinded neuroradiologist.

RESULTS:
Phantom studies showed no signs of artifacts. The prototype showed a reliable clamping and reopening after clip application, although the clamping force was reduced. In vivo studies showed a successful occlusion of the renal artery in all cases in the magnetic resonance angiography. Clip artifacts were statistically significant reduced in the prototype group (P < .01). CF-PEEK showed no signs of impaired biocompatibility compared with the titanium samples in vitro and in vivo.

CONCLUSION:
Former attempts of metal-free aneurysm clips did not meet the criteria of the standard clip design. In this study, the practicability of this new CF-PEEK artifact-free aneurysm clip has been proven. The further fabrication developments should overcome the problem of a reduced clamping force in the future. After clinical approval, it will improve the magnetic resonance image quality and might help to reduce the amount of digital subtraction angiography in the follow-up.
CAREER ATTITUDES AND PROACTIVE BEHAVIOR OF EMPLOYEE
Authors: Gurieva Svetlana D. , Yumkina Ekaterina A. , Timofeeva Alena S. 
Published: December 2023

Proactivity today is one of the concepts actively developed in applied psychology and is considered as a key feature of job crafting or constructive design by a person of his work.
The purpose of this article is to study personal proactivity in mediating the career orientations of working professionals. The study involved 40 sales managers. Data collection methods: questionnaire “Career Anchors” by E. Shane and “PVQ self-rating” (author’s development). The construct of proactivity was presented in the self-assessment methodology through the qualities of initiative, independence, perseverance, responsibility.
Conclusions. Initiative, as the central link of proactivity, is associated with a whole range of properties that are responsible both for the general self-confidence of the individual and with specific skills to express and implement their goals. Factor analysis showed that initiative and responsibility are different aspects of personal proactivity. Proactive personal qualities indirectly mediate success in the implementation of career strategies and subjective satisfaction with professional self-realization.
Long-term patient-centred outcomes of periacetabular osteotomy in a large consecutive series
Authors: Berwin James T. , Duffy Sean D. X. , Gargan Martin F. , Barnes James R. 
Published: December 2023

AimsWe assessed the long-term outcomes of a large cohort of patients who have undergone a periacetabular osteotomy (PAO), and sought to validate a patient satisfaction questionnaire for use in a PAO cohort.MethodsAll patients who had undergone a PAO from July 1998 to February 2013 were surveyed, with several patient-reported outcome measures (PROMs) and radiological measurements of preoperative acetabular dysplasia and postoperative correction also recorded. Patients were asked to rate their level of satisfaction with their operation in achieving pain relief, restoration of activities of daily living, ability to perform recreational activity, and their overall level of satisfaction with the procedure.ResultsA total of 143 PAOs were performed between 1998 and 2013. Of those, 90 postoperative surveys were returned. Only 65 patients (73 hips) had both pre- and postoperative radiographs available for measurement. The mean time to follow-up was 15 years (6.5 to 20). Most patients were female (91%), with a mean age of 26.4 years (14.9 to 48.3) at the time of their surgery. A statistically significant improvement in radiological correction was detected in all hips (p < 0.001). A total of 67 patients (92.3%) remained either very satisfied or satisfied with their PAO. The internal consistency of the patient satisfaction questionnaire, measured using Cronbach’s α, ranged from 0.89 to 0.94 indicating ‘good’ to ‘excellent’ reliability.ConclusionOutcomes of importance to patients undergoing a PAO include several key domains: pain relief, improve activities of daily living, and improve recreational ability. Our study demonstrates high rates of long-term patient satisfaction in all domains, and found the patient satisfaction questionnaire to be a valid and reliable instrument for use in this cohort.Cite this article: Bone Jt Open 2023;4(12):964–969.
Design of a highly sensitive terahertz temperature and refractive index composite sensor based on an InSb–Ag composite grating
Authors: Zhang Chunli , Liu Yanfei , Li Jing , Wu Qiannan , Li Mengwei 
Published: December 2023

This paper introduces an exceptionally highly sensitive sensor developed using InSb–Ag composite gratings for sensing temperature and refractive index in the terahertz region. The structural parameters of the sensor were optimized to produce two transmission spectra at frequencies of 2.016 THz and 10.428 THz, respectively, under T=290K with transverse magnetically polarized vertical incidence. The simulation results demonstrate that the temperature sensor displays a sensitivity of 25.27 GHz/K and 4.53 GHz/K; the respective refractive index sensor shows a sensitivity of 0.48 THz/RIU and 3.60 THz/RIU. The current paper analyzes the effects of incidence and polarization angles on the performance of the sensors. The findings indicate that polarization significantly correlates with the sensor. Regarding the incidence angle range of 0°–30°, the performance of the sensors is uncorrelated with the angle of incidence. Compared to other temperature and refractive index sensors, the composite grating sensor demonstrates superior sensing performance and holds great potential for developing high-performance dual-function sensors.
Die ethischen Implikationen von Prozessdaten: Eine systematische Literaturanalyse von Datenethik und Process Mining
Authors: Gabdoulline Gulnara , Kern Christopher Julian , Krönung Julia 
Published: December 2023

ZusammenfassungProcess Mining (PM) stellt eine wachsende Disziplin dar, die aufgrund ihres Potenzials zur Verbesserung von Geschäftsprozessen immer mehr Aufmerksamkeit von Forschern und Anwendern auf sich zieht. Wie jede neue Technologie gibt es jedoch auch im Kontext von PM-Bedenken hinsichtlich der ethischen Anwendung. Gerade bezogen auf Erhebung, Verarbeitung und Nutzung von Daten kann es hierbei zu Problemen kommen. Dieser Artikel zielt daher darauf ab, anhand einer Literaturanalyse ethische Implikationen im Process Mining herauszuarbeiten. Dabei wurden 39 Artikel aus sechs Zeitschriften im Bereich PM und 24 Artikel aus vier Zeitschriften im Bereich Datenethik analysiert. Die Ergebnisse zeigen das wachsende Interesse an der Datenethik und PM, aber es befasst sich nur ein geringer Anteil der analysierten PM-Artikel mit datenethischen Grundsätzen. Weitere Forschung ist in Bereichen bestimmter datenethischer Grundsätze, wie Datenqualität und der informierten Zustimmung, erforderlich. Insgesamt bietet diese Studie einen Ausgangspunkt für weitere Forschungen zur ethischen Nutzung von Daten bei der Anwendung von PM und verdeutlicht, dass diesem Bereich mehr Aufmerksamkeit gewidmet werden sollte.
Novel five nucleotide deletion in dysferlin leads to autosomal recessive limb‐girdle muscular dystrophy
Authors: Chen Yen‐Lin , Wu Wen‐Bin , Wang Pei , Yip Ping‐Keung , Wu Yi‐No , Lin Ying‐Hung , Lin Wei‐Ning 
Published: December 2023

AbstractMuscular dystrophy (MD) is a genetic disorder that causes progressive muscle weakness and degeneration. Limb‐girdle muscular dystrophy (LGMD) is a type of MD that mainly causes muscle atrophy within the shoulder and pelvic girdles. LGMD is classified into autosomal dominant (LGMD‐D) and autosomal recessive (LGMD‐R) inheritance patterns. Mutations in the Dysferlin gene (DYSF) are common causes of LGMD‐R. However, genetic screening of DYSF mutations is rare in Taiwan. Herein, we identified a novel c.2867_2871del ACCAG deletion and a previously reported c.937+1G>A mutation in DYSF from a Taiwanese family with LGMD. The primary symptoms of both siblings were difficulty climbing stairs, walking on the toes, and gradually worsening weakness in the proximal muscles and increased creatine kinase level. Through pedigree analysis and sequencing, two siblings from this family were found to have compound heterozygous DYSF mutations (c. 937+1G>A and c. 2867_2871del ACCAG) within the separated alleles. These mutations induced early stop codons; if translated, truncated DYSF proteins will be expressed. Or, the mRNA products of these two mutations will merit the nonsense‐mediated decay, might result in no dysferlin protein expressed. To our knowledge, this is the first report of a novel c.2867_2871del ACCAG deletion in DYSF. Further research is required to examine the effects of the novel DYSF mutation in Taiwanese patients with LGMD.
Everyday referenced use of a digital temperature sensor – how well do alternative ice cubes really cool a drink?
Authors: Fleischer Timo , Feichtner Julia , Strauß Isabella , Strahl Alexander 
Published: December 2023

Abstract
In this paper, the cooling effect of alternative ice cubes made of granite, soapstone and ceramic is experimentally examined with the help of a digital temperature sensor and compared with that of a conventional ice cube. Digital sensors can be integrated in an everyday referenced way in the sense of inquiry-based learning during experimentation in chemistry lessons, since the use of ice cubes is a typical everyday situation that many students know and is therefore well suited for everyday referenced chemistry lessons. The advantages of digital sensors include the easy recording of measured values, the automatic creation of tables and graphs, and the direct link between the experiment and the representation. The results of the experiment reveal that the water ice cube has by far the greatest cooling effect compared to the alternative ice cubes. The entire cooling process of the ice cubes is explained and calculated, which essentially consists of three sub-steps: heating the ice cubes to melting temperature, melting the ice cubes, mixing the melted ice cube with the drink. The comparison of calculated and experimentally measured values shows that the cooling effect of all ice cubes could be determined very accurately experimentally using the digital temperature sensor.