bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights into GATOR2-dependent interactions and its conformational changes in amino acid sensing
Authors: Yang Can , Sun Xuan , Wu Geng 
Published: February 2024

Abstract
Eukaryotic cells coordinate growth under different environmental conditions via mechanistic target of rapamycin complex 1 (mTORC1). In the amino-acid-sensing signalling pathway, the GATOR2 complex, containing five evolutionarily conserved subunits (WDR59, Mios, WDR24, Seh1L and Sec13), is required to regulate mTORC1 activity by interacting with upstream CASTOR1 (arginine sensor) and Sestrin2 (leucine sensor and downstream GATOR1 complex). GATOR2 complex utilizes β-propellers to engage with CASTOR1, Sestrin2 and GATOR1, removal of these β-propellers results in substantial loss of mTORC1 capacity. However, structural information regarding the interface between amino acid sensors and GATOR2 remains elusive. With the recent progress of the AI-based tool AlphaFold2 (AF2) for protein structure prediction, structural models were predicted for Sentrin2-WDR24-Seh1L and CASTOR1-Mios β-propeller. Furthermore, the effectiveness of relevant residues within the interface was examined using biochemical experiments combined with molecular dynamics (MD) simulations. Notably, fluorescence resonance energy transfer (FRET) analysis detected the structural transition of GATOR2 in response to amino acid signals, and the deletion of Mios β-propeller severely impeded that change at distinct arginine levels. These findings provide structural perspectives on the association between GATOR2 and amino acid sensors and can facilitate future research on structure determination and function.
Construction of Artificial Vagina
Authors: Banerjee M. S. 
Published: February 2024

Summary1. The present series consists of 11 cases of congenital absence of vagina. Surgical construction of artificial vagina was done in 10 cases following Shears' modification of Wharton's technique.2. Initially, split thickness skin graft was used only in I case. Of the remaining 9, only 6 had spontanous epithelisation of the cavity, 2 subsequently required insertion of skin graft, and I had contracture of vagina.3. Importance of skin grafting of the newly constructed canal is emphasized.4, Long term result was satisfactory in all married women.
Considerations in Management of Contractures of the Neck
Authors: Sawhney Chander Parkash 
Published: February 2024

SummaryBehaviour of skin grafts on neck has been studied and effective measures in the form of a P.O P. splint after 7th postoperative day and subsequently a cervicai collar of simple design are recommended to prevent contracture of skin grafts on neck in cases of cervical contractures. The cervical collar properly used significantly stretches the graft and thereby improve the results of repair.
Unilateral Hyperplasia of the Mandibular Condyle
Authors: Khanna N. N. , Gupta S. K. , Sood P. C. , Khanna S. 
Published: February 2024

SummaryA twenty-two years old patient with a unilateral hyperpiasia of the mandibular condyle has been presented. The clinical and radiological features and the current methods of treatment have been discussed.
Replacement of the Soft Tissue Loss of the Distal Phalanx Index Finger—A Convenient Method
Authors: Bafna P. L. , Pande S. K. , Baid J. C. 
Published: February 2024

SummaryA convenient method for covering the soft tissue loss of the distal phalanx of the index finger is described. This can be done under local Anaesthesia as an outdoor procedure and gives good cosmetic and functional covering.
Oxyphenbutazone in Plastic Surgery
Authors: Chowdhury Joya 
Published: February 2024

SummaryTo summarise, a preliminary report of acontrolled trial with Oxyphenbutazone in 100 cases undergoing plastic surgery is presented and the evaluation assessed in three Grades and expressed in figures.It is felt that this drug has proved useful in alleviating pain and reducing post operative swelling and ecchymosis. The trial is being continued for another year.
Cephalometric studies in Palatopharyngeal Complex
Authors: Rohatgi Sheila , Ganguli A. C. , Kundu R. N. 
Published: February 2024

SummaryA total of 207 cases have been studied for assessing the velopharyngeal dimensions by cephalometry. Of these 106 individuals with normal speech served as a baseline with whom 101 cases of cleft palate were compared to assess the lengths of the hard palate, the axial length of the soft palate and the nasopharyngeal depth.Importance of cephalometry as an investigation to assess the anatomy, speech pathology and for suggsting appropriate surgery have been discussed.At the end I would like to thank all those people who helped me complete this paper for presentation. Mr. S. Ghosh and Mr. Prabir Dey without whose cooperation the X-rays would not have been possible.
Contraction and Relaxation in Split Skin Autografts—A Human Study
Authors: Keswani R. K. , Goel N. K. 
Published: February 2024

Summary1. Intermediate skin grafis were applied in 30 patients after obtaining a clean surgical wound.2. Detailed measurement studies have revealed that such grafts contract during the first four weeks post-operatively.3. Relaxation begins after 4 to 8 weeks so that the ultimate area of skin graft is larger than during its period of maximum contraction.4. Some skin grafts relax/grow to a larger size than the original area of the skin graft applied at time of operation.5. Most skin grafts, however, do not regain the original area.
Behaviour of Skin Grafts as Regards Changes in its Linear Dimensions
Authors: Sawhney C. P. 
Published: February 2024

Summary(1) Behaviour of 60 split skin grafts from various representative regions of the body have been studied by obser vations extending over a period of upto 5 years.(2) The skin grafts pass through three stages during their life:(i) Stage of apparent graft contraction which lasts from 2 weeks to 2 months.(ii) Stage of slow and prolonged relaxation which last upto 10 months.Stage of settlement when the graft finally adjusts to its new surroundings and left to itself does not change its dimensions after wards.(3) Finally the graft is smaller than its original size but this true contraction is less than the earlier apparent contraction.
Congenital Urethral Fistula With Stricture of Glandular Urethra
Authors: Yadava Vishwa Nath Sahai , Chandra Ramesh , Sharma Ravindra Naih 
Published: February 2024

SummaryAn extremely rare congenital abnormality of the urethra characterized by a congenital fistula and associated with a stricture of the glandular portion has been presented.
Role of Groin Flap in Acute Hand Injuries
Authors: Thind Rajinder Singh , Singh Ajaipal 
Published: February 2024

SummaryThe clinical experience of resurfacing acute hand injuries requiring full thickness cover in a series of 25 cases with groin flap has been presented. The anatomical basis of this unique and versatile flap has been discussed and its special merits have been brought out. We recommend the use of this flap as an emergency procedure in cases of acute hand trauma in view of its suitability speed, safety, adaptability and dexetrity.
Ward Infections—A Study of Morbidity During three years
Authors: Chari P. S. 
Published: February 2024

SummaryThe state of infection in the Division of Plastic Surgery at Post-graduate Institute of Medical Education and Research, Chandigarh over a period of three years has been described. The incresing prevalence of gram negative organism in nosocomial infections has been observed. An acceptable rate of wound infection in “clean cases” can be achieved by vigilance and simple measures.
Candida Albicans Infection in Burn
Authors: Sinha R. C. , Sinha B. D. 
Published: February 2024

Summary1. Forty cases of burns were studied to detect the incidence of possible secondary infection by candida albicans.2. In the seven & half percent of cases candida albicans infection have been detected.3. In all the above patients, it was found that patients were run down and their immune mechanism were suppressed due to prelonged used of modern antibiotics and/or steroids.
An Analysis of Faciol Clefts
Authors: Khanna N. N. , Sood P. C. , Tripathi F. M. , Sinha J. K. , Agarwal A. K. 
Published: February 2024

SummaryThis paper is based on our observations in 833 cases of facial clefts seen at Varanasi. The clefts predominated in males in the ratio of 2.1: 1. Isolated cleft palates were equal in the two sexes, Besides this cleft palate alone constituted a much higher percentage in some of the Northern Countries than observed in India. Other congential anomalies were present in 5%, of the cases.
A New Technique of Anchoring the Mabilised Muco-periosteal Flap to the Underlying Bone in Cleft Palate Surgery
Authors: Mohan Madan , Appukuttan P. K. , Sreenivasan A. 
Published: February 2024

SummaryA new technique of anchoring the mobilised muco-periosteal flap in cleft palate surgery is described in detail. The merits of this technique are compared to others and are aiso discussed.
Reconstruction in Congenital Anomalies of Vagina
Authors: Khanam Wazira , Rashid P. A. 
Published: February 2024

SummaryFourteen cases have been studied on congenital anomalies of vagina, viz 5 cases of congenital absence of vagina, 4 septate vagina and 5 imperforated hymen.A detailed clinical history and physical examination was conducted on all such cases. However, special investigations were carried out in 5 cases with congenital absence of vagina.Urological anomalies were detected in 3 cases.Plastic repair of vagina was done in 4 cases of absent vagina, using skin graft over dental material mould, good results were obtained in 3 cases and fair in one case No mayor post operative compitition was observed in the cases among the present series.
Persistent Urogenital Membrane in Femaie Children Over tie Vaginal Vestibule
Authors: Yodava V. N. S. , Tiwari V. S. 
Published: February 2024

SummaryThis article consists of seven female children with alike congenital problem creating great psychological set back to their parents. The children had persistant urogenital membrane in vestibular area except with a very small opening for urinar; passage. This being a rare congenital anomaly with its very simple technique of its cure, to relieve the mental worry of the parents, prompted us to put this in the literature for further exploration of its etiology and existence.
Designs of Splints for Preventing Skin Graft Contraction and Study of their effectiveness
Authors: Sawhney C. P. 
Published: February 2024

SummaryThe rationale and design of splints to be worn after release of contractures has been presented. Whereas compression splints need to be worn for 6 months, the traction splints have to be muaintained for longer peri ds. The compression splints are more crective than traction splints in preventing contraction of skin grafts.
Use of Intravital Dyes in the Assessment of Deep Burns
Authors: Sinha R. C. , Sinha J. D. P. 
Published: February 2024

Summary1. Twenty cases of burns of varying extent were studied in which early excision of areas of deep burn with skin grafting was practised. The deep burn was outlined by Disulphine blue.2. Another 20 cases were studied in which conservative treatment was given and grafting was done in 3-4 weeks after injury when the slough had separated.3. It was observed thatin early excision series the period of hospitalization was 30 to 60% less and development of complications was 20-30% less. The mortality was also found to be nil whereas there was 10% mortality in conservative series.
Carcinoma in Split Skin Graft
Authors: Keswani R. K. , Jain R. L. , Beniwal J. S. , Sunil Kumar 
Published: February 2024

SummaryTwo cases of epidermoid carcinoma following surface SSG-one over the right leg and another over the scalp are reported here, Such a complication should be carefully looked for and kept in mind during followup in all skin grafts.
The Use of Apron Flap in Head and Neck Malignancy (A case report)
Authors: Yaday V. N.S. , Sharma R. N. , Agrawal P. K. 
Published: February 2024

SummaryThe apron flap has been used in a 12 years boy of with giant cell epulis of the Jower jaw with good cosmetic and functional result, accomplished by one stage reconstruction.
Penile Agenesis
Authors: Gupta I. J. , Chandra Ramesh 
Published: February 2024

SummaryThis rare congenital znomaly had been reported in only 37 cases The condition is a result of incomplete development of the genital tubercle. Other urogenital anomaly should be investigated thoroughly. The sex assignment should be done by taking into consideration the psychological aspect, harmonal and chromosomal study. The surgical interference should be done in those cases who survive infancy and childhood.
Accessory Scrotum (A Case Report)
Authors: Joharapurkar S. R. , Gupta A. K. , Shende M. B. , Potwar S. A. 
Published: February 2024

SummaryA case report of accessory scrotum associated with coronal hypospadias with chordee, bifid scrotum and anal stenosis is presented. No corrective surgery was performed as the boy was too young and was asked to come after the age of cne and half years.
Linking institutional context to the community and career embeddedness of skilled migrants: The role of destination- and origin-country identifications
Authors: Stahl Günter K. , Akkan Eren , Reiche B. Sebastian , Hajro Aida , Zellmer-Bruhn Mary , Lazarova Mila , Richter Nicole Franziska , Caprar Dan V. , Zikic Jelena , Björkman Ingmar , Brewster Chris , Cerdin Jean-Luc , Clegg Callen C. , Davoine Eric , Koveshnikov Alexei , Mayrhofer Wolfgang , Zander Lena 
Published: February 2024

AbstractMigration is one of the most pressing global issues of our time. However, relatively little is known about the factors and mechanisms that govern the post-migration experiences of skilled migrants. We adopt an acculturation- and social identity-based approach to examine how differences between institutional characteristics in the destination and origin country, as well as migrants’ experiences with formal and informal institutions shape their identification with the destination and origin country and contribute to their community and career embeddedness. Our study of 1709 highly skilled migrants from 48 origin countries in 12 destination countries reveals that the institutional environment migrants encounter provides both sources of opportunity (potential for human development and value-congruent societal practices) and sources of disadvantage (experienced ethnocentrism and downgrading). These contrasting dynamics affect migrants’ destination-country identification, their origin-country identification and, ultimately, their embeddedness in the destination country. Our results have important implications for multinational enterprises and policy makers that can contribute to enhancing skilled migrants’ community and career embeddedness. For example, these actors may nurture a work environment and provide supportive policies that buffer against the institutional sources of disadvantage we identified in this study, while helping migrants to leverage the opportunities available in the destination country.
Reactive Management of University Reputation During the COVID Crisis: Governance and the Control of Public Narratives in Chinese Higher Education
Authors: Sun Zhuo 
Published: February 2024

AbstractReputation management (RM) is initially applied within business research, whereas under the premise of commercialisation of higher education (HE), this concept has been widely studied in HE realm. China, as one of the emerging countries in global competitions, RM was initially borrowed from Anglo-Saxon HE, and it gradually developed in Chinese HE. However, most of the studies focussing on promotion strategies, which implies crisis management could be dismissed; thus, further studies are needed to develop the holistic picture of RM in Chinese universities. Particularly, how COVID-19 casts an impact on RM in Chinese HE and its link to governance is rarely discussed. This study adopts an active/reactive RM framework to explore the practices of Chinese universities from practitioner’s perspective. The findings suggest that RM in Chinese HE is underdeveloped and overly focussed on external audiences. In response to crises, Chinese universities rely on public narrative control, known as 'Yuqing' management. ‘Yuqing’ directly translates into public opinions, yet it has political impact and reflects the generalisation of prevalence societal opinions and political attitude of people. The rationale of this is deeply rooted within the how Chinese universities are governed, i.e. the financial and political harness.
Exploring socioeconomic similarity-inequality: a regional perspective
Authors: Mouronte-López Mary Luz , Savall Ceres Juana 
Published: February 2024

AbstractSocioeconomic variables have been studied in many different contexts. Considering several socioeconomic variables as well as using the standard series clustering technique and the Ward’s algorithm, we rank the countries in the world and evaluate the similarity and inequality between geographic areas. Various relationships between variables are also identified. Additionally, since the Gini coefficient is one of the most frequently used metrics to measure economic inequality, with a global scope, we model this coefficient utilising machine learning techniques. 16 exploratory variables are utilised, which pertain to the health (9), economic (2), social labour protection (4) and gender (1) fields. International repositories that include time series of variables referred to these domains as well as education and labour market fields are used.
Multimodal metaphors in a Sino-British co-produced documentary
Authors: Wei Xixi 
Published: February 2024

AbstractMetaphor is an important tool for people to use in their perception of the world, but its representational forms vary across genres. Using Nvivo 12 plus as a tool, this study employs a combination of quantitative and qualitative methods to investigate the multimodal metaphorical representations, modal characteristics and cognitive rationales in the Sino-British co-produced documentary Through the Seasons: China. It has been discovered that: (1) Multimodal metaphorical representations in documentaries are found to be divided into two primary categories and five sub-categories. Implicit source-verbal and pictorial target is the primary way of representation for documentaries. (2) Various modes, including verbal mode, pictorial mode, verbal and pictorial mode, and implicit mode are employed in documentaries. However, the most commonly used modes are verbal and pictorial mode as well as implicit mode. The relationship between verbal and pictorial modes in the documentary is primarily characterised by juxtaposition and interpretation. (3) The documentary’s genre attributes and purpose, as well as the target audience’s physical and cultural experiences, are important cognitive justifications for the multimodal approach to metaphorical representation. This study further enriches the study of multimodal metaphorical representations and contributes to the theoretical refinement of multimodal metaphors. Additionally, it offers a theoretical reference for the development of dynamic multimodal discourses, such as documentaries, and aids in the improvement of audiences’ multimodal literacy.
Chlamydia retesting remains low among young women in Australia: an observational study using sentinel surveillance data, 2018–2022
Authors: Munari Stephanie C. , Wilkinson Anna L. , Asselin Jason , Owen Louise , Read Phillip , Finlayson Robert , Martin Sarah , Bell Charlotte , O’Connor Catherine C. , Carter Allison , Guy Rebecca , McNulty Anna , Varma Rick , Chow Eric P. F. , Fairley Christopher K. , Donovan Basil , Stoove Mark , Goller Jane L. , Hocking Jane , Hellard Margaret E. 
Published: February 2024

Background Chlamydia remains the most notified bacterial sexually transmissible infection in Australia with guidelines recommending testing for re-infection at 3 months post treatment. This paper aimed to determine chlamydia retesting and repeat positivity rates within 2–4 months among young women in Australia, and to evaluate what factors increase or decrease the likelihood of retesting. Methods Chlamydia retesting rates among 16–29-year-old women were analysed from Australian Collaboration for Coordinated Enhanced Sentinel Surveillance of sexually transmissible infection and bloodborne virus (ACCESS) sentinel surveillance data (n = 62 sites). Among women with at least one positive test between 1 January 2018 and 31 August 2022, retesting counts and proportions within 2–4 months were calculated. Logistic regression was performed to assess factors associated with retesting within 2–4 months. Results Among 8758 women who were positive before 31 August 2022 to allow time for follow up, 1423 (16.2%) were retested within 2–4 months, of whom 179 (12.6%) tested positive. The odds of retesting within 2–4 months were 25% lower if tested in a coronavirus disease 2019 (COVID-9) pandemic year (2020–2022) (aOR = 0.75; 95% CI 0.59–0.95). Among 9140 women with a positive test before 30 November 2022, 397 (4.3%) were retested too early (within 7 days to 1 month) and 81 (20.4%) of those were positive. Conclusions Chlamydia retesting rates remain low with around a sixth of women retested within 2–4 months in line with guidelines. Re-infection is common with around one in eight retesting positive. An increase in retesting is required to reduce the risk of reproductive complications and onward transmission.
Thin-body effects in double-gate tunnel field-effect transistors
Authors: Chien Nguyen Dang , Thai Bui Huu , Shih Chun-Hsing 
Published: February 2024

Abstract
Scaling down the body thickness (T
b) of double-gate tunnel field-effect transistors (DG-TFETs) is helpful in suppressing short-channel effects, but it may give rise to thin-body effects (TBEs). Based on 2D device simulations, this study examines the mechanisms and influences of TBEs in DG-TFETs as T
b is scaled down. Differently from previous beliefs, the on-current degradation in thin-body DG-TFETs is not mainly caused by the volume effect, but rather by a newly defined TBE named lateralization effect. This is because the lateralization of tunneling direction significantly increases tunnel width, whereas the reduction of tunneling volume is quite limited due to narrow tunneling regions. To study the T
b-dependence of current, therefore, the vertical tunneling has to be taken into consideration. When considered as a TBE, the fringing field effect caused by reduction in T
b is not significant in degrading the on-current of thin-body DG-TFETs because the narrow tunneling regions are strongly gate-controlled. The only TBE that enhances the on-current is the coupling effect, but its role is only significant for low-bandgap bodies in which the coupling effect can efficiently promote the tunneling towards the body center. Not as previously thought that the quantum confinement effect monotonically increased, it even decreases as T
b decreases down to sub-10 nm before turning to increase, thanks to the space sharing between proximate local quantum wells. A comprehensive understanding of the TBEs is useful for providing design insight, especially for determining the optimal T
b to maximize the on-current.
A nanoscale study of hafnium oxide resistive memory switching dynamics
Authors: Blonkowski S , BenYoussef M , Kogelschatz M 
Published: February 2024

Abstract
This paper deals with the set and reset time measurements of a resistive memory consisting of a Ti/TiN/HfO2 layer stack contacted with the tip of a conductive atomic force microscope in ultra high vacuum. We present measurements of the set and reset switching times in voltage pulse regime for different voltages and compliance currents. The experimental results are well reproduced by simulation. We derive analytical expressions for the set and reset times as function of experimental conditions. The effect of voltage and current on reset and set switching times is then discussed with the help of their analytical expressions, which are also applied on standard devices characteristics.