bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latin-American consensus on the transition into adult life of patients with X-linked hypophosphatemia
Authors: Kastelic Maria Sofia , Roman-González Alejandro , De Paula Colares Neto Guido , De Paula Francisco J. A. , Reza-Albarrán Alfredo Adolfo , Morales Lilian Reyes , Tormo Silvina , Meza-Martínez Adriana Isabel 
Published: December 2023

Abstract
Introduction
X-linked hypophosphatemia is an orphan disease of genetic origin and multisystem involvement. It is characterized by a mutation of the PHEX gene which results in excess FGF23 production, with abnormal renal and intestinal phosphorus metabolism, hypophosphatemia and osteomalacia secondary to chronic renal excretion of phosphate. Clinical manifestations include hypophosphatemic rickets leading to growth abnormalities and osteomalacia, myopathy, bone pain and dental abscesses. The transition of these patients to adult life continues to pose challenges to health systems, medical practitioners, patients and families. For this reason, the aim of this consensus is to provide a set of recommendations to facilitate this process and ensure adequate management and follow-up, as well as the quality of life for patients with X-linked hypophosphatemia as they transition to adult life.

Materials and Methods
Eight Latin American experts on the subject participated in the consensus and two of them were appointed as coordinators. The consensus work was done in accordance with the nominal group technique in 6 phases: (1) question standardization, (2) definition of the maximum number of choices, (3) production of individual solutions or answers, (4) individual question review, (5) analysis and synthesis of the information and (6) synchronic meetings for clarification and voting. An agreement was determined to exist with 80% votes in favor in three voting cycles.

Results and Discussion
Transition to adult life in patients with hypophosphatemia is a complex process that requires a comprehensive approach, taking into consideration medical interventions and associated care, but also the psychosocial components of adult life and the participation of multiple stakeholders to ensure a successful process. The consensus proposes a total of 33 recommendations based on the evidence and the knowledge and experience of the experts. The goal of the recommendations is to optimize the management of these patients during their transition to adulthood, bearing in mind the need for multidisciplinary management, as well as the most relevant medical and psychosocial factors in the region.
Complicated Role of Post-translational Modification and Protease-Cleaved Fragments of Tau in Alzheimer’s Disease and Other Tauopathies
Authors: Yang Jie , Shen Naiting , Shen Jianying , Yang Ying , Li Hong-Lian 
Published: December 2023

AbstractTau, a microtubule-associated protein predominantly localized in neuronal axons, plays a crucial role in promoting microtubule assembly, stabilizing their structure, and participating in axonal transport. Perturbations in tau’s structure and function are implicated in the pathogenesis of neurodegenerative diseases collectively known as tauopathies, the most common disorder of which is Alzheimer’s disease (AD). In tauopathies, it has been found that tau has a variety of post-translational modification (PTM) abnormalities and/or tau is cleaved into a variety of fragments by some specific proteolytic enzymes; however, the precise contributions of these abnormal modifications and fragments to disease onset and progression remain incompletely understood. Herein, we provide an overview about the involvement of distinctive abnormal tau PTMs and different tau fragments in the pathogenesis of AD and other tauopathies and discuss the involvement of proteolytic enzymes such as caspases, calpains, and asparagine endopeptidase in mediating tau cleavage while also addressing the intercellular transmission role played by tau. We anticipate that further exploration into PTMs and fragmented forms of tau will yield valuable insights for diagnostic approaches and therapeutic interventions targeting AD and other related disorders.
Evaluation of Spatio-temporal Variability of a Flood Using the Hydrological Process of Flood Frequency in Ghagra River Basin, India
Authors: Verma Rahul , Rai Suresh Chand 
Published: December 2023

Abstract
The present research study aims to analyze flood frequency to relate flood magnitudes with corresponding return periods. These estimates are crucial for the development of flood-preventive hydrological infrastructures and flood plain zoning, etc. Basin-wide high intensity of rainfall and high discharge from the upper riparian region during monsoon months creates flooding in the middle and lower reaches of the Ghagra River basin. Therefore, the flood estimates for three gauging sites situated on the mainstream of the Ghagra River viz., Elginbridge, Ayodhya, and Turtipar, have been comprehended using the Gumbel distribution (Extreme Value Type I) method and the Log-Pearson Type III distribution method. Flood estimates are calculated for 1.01, 1.05, 1.11, 1.25, 2, 5, 10, 20, 50, 100, 200, and 500 years return periods considering flood time series of 50 years to reduce estimation uncertainty. The findings of flood frequency analysis (FFA) revealed that the probability of occurrence of the flood is more than 80% at all three sites because Ghagra River can carry around 7800 to 9000 m3/s of water discharge without posing a high risk of levee break. The upper and lower limits of discharge carrying capacity depend on the river’s desiltation process. Hence, the flood occurs almost every year in the basin; its only variation is its severity. The rainfall-runoff relationship is estimated by integrating a simple linear model and for rainfall trend analysis Mann-Kendall is applied. Linear regression analysis-based rainfall-runoff relationship outcomes revealed a significant relationship with a positive correlation coefficient i.e., 0.2722 for Elginbridge, 0.39624 for Ayodhya, and 0.4844 for Turtipar gauging site in the monsoon season but other factors like a high amount of water discharge from dams in upper riparian regions, etc. are also responsible for flooding in the middle and lower reaches. The Mann-Kendall trend analysis shows a decrease in annual average rainfall and rainfall in the monsoon season. Discharge variability indicates the direct relationship between flood fury and changes in climatic patterns in recent decades. This paper identifies that future research is needed to better inform the policy planners who strive to design sustainable infrastructure.
Decadal Variations in Area under Different Soil Erosion Classes using RUSLE and GIS: Case Studies of River Basins from Western and Eastern Arunachal Pradesh
Authors: Vese M. , Mishra P. , Singh W. R. , Lowang P. , Assumi S. , Bandyopadhyay A. , Bhadra A. 
Published: December 2023

Abstract
This study provides a comparative evaluation of spatio-temporal distribution of soil erosion in Western (Mago Basin) and Eastern (Dibang Basin) basins of Arunachal Pradesh, India as these two basins are vulnerably exposed to soil erosion due to its topographical characteristics of mountainous steep slope and experiences heavy rainfall. The study was carried out for a ten-years period (2003 to 2014) using RUSLE model which encompasses five important factors contributing to soil erosion. Rainfall erosivity (R factor) map was calculated using Climate Prediction Center gridded precipitation. Soil map and soil samples were used to analyze soil erodibility (K factor) map. Slope length and slope steepness (LS factor) maps were computed from SRTM DEM (30 m resolution). MODIS NDVI images were used to obtain cover management (C factor) map. Landuse Landcover map was used to obtained support practice (P factor) map. Higher value in rainfall erosivity and cover management factor was observed in Mago basin which contributed to higher average annual soil loss of 17.423 t ha−1 y−1 in Mago basin and 5.461 t ha−1 y−1 in Dibang basin, whereas the other three factor values were almost the same. The spatial maps showed 56.65% of Mago basin area and 76.27% of Dibang basin area was under the class of slight erosion, with the remaining areas of moderate to severe erosion risk for both the basins. Temporal average soil erosion in Mago basin varied within moderate to very high erosion classes whereas Dibang basin erosion classes varied from slight to moderate. The temporal trend line showed that the overall soil erosion was increasing at an alarming rate for Mago basin whereas a slight increase in Dibang basin was observed.
Nature of the Two Episodes of Paleoproterozoic Magmatism (2495 Ma and 2190 Ma) in the Trans-North China Orogen, North China, with Implications for the Tectonic Evolution
Authors: Liu Haiyan , Peng Chong , Zhang Ruiying , Kong Dewei , Jofrisse Cremilda Samuel , Xue Linfu , Pan Baozhi 
Published: December 2023

Abstract
Understanding the temporal and spatial evolution of the North China Craton (NCC) basement, formed by amalgamation, is a crucial issue in global geosciences. The Huozhou complex is situated at the core of the Trans-North China Orogen (TNCO) in the NCC and comprises a considerable number of Palaeoproterozoic granitic gneisses, providing valuable insights into the tectonic evolution of the TNCO. In this study, comprehensive field geological surveys, petrology, chronology, geochemistry, and Hf isotope analysis were conducted to investigate the genesis and tectonic context of the Xingtangsi and Zhengnangou granitic gneisses and elucidate the TNCO’s tectonic evolution. The Xingtangsi granite gneiss yielded a magmatic zircon age of 2495±34 Ma, implying its Palaeo-proterozoic or Archean origin, as previously suggested. Its protolith was I-type peraluminous granite, primarily generated through the partial melting of pre-existing continental crust materials with a small quantity of mantle-derived magma. The Zhengnangou granitic gneiss’s protolith was A-type granite, and its magmatic zircon age was 2,190 ±11 Ma, indicating its Palaeoproterozoic origin rather than Archean. TDM1(Ma) for the Zhengnangou granitic gneiss ranged from 2,424 to 2,498 Ma, TDM2(Ma) varied from 2563 to 2684 Ma, and the εHf(t) value ranged from 1.3 to 3.3. These results suggest that it was primarily derived from newly formed crustal materials without any mantle-derived addition. Integrating our data with the literature, the ∼2.5 Ga magmatic activity in the Huozhou area may have formed in the tectonic setting of the continental arc, and ∼2.2 Ga A-type granite may have formed in a post-collisional extensional environment.
Optimized Mask-RCNN model for particle chain segmentation based on improved online ferrograph sensor
Authors: Wang Shuo , Wan Miao , Wu Tonghai , Bai Zichen , Wang Kunpeng 
Published: December 2023

AbstractFerrograph-based wear debris analysis (WDA) provides significant information for wear fault analysis of mechanical equipment. After decades of offline application, this conventional technology is being driven by the online ferrograph sensor for real-time wear state monitoring. However, online ferrography has been greatly limited by the low imaging quality and segmentation accuracy of particle chains when analyzing degraded lubricant oils in practical applications. To address this issue, an integrated optimization method is developed that focuses on two aspects: the structural re-design of the online ferrograph sensor and the intelligent segmentation of particle chains. For enhancing the imaging quality of wear particles, the magnetic pole of the online ferrograph sensor is optimized to enable the imaging system directly observe wear particles without penetrating oils. Furthermore, a light source simulation model is established based on the light intensity distribution theory, and the LED installation parameters are determined for particle illumination uniformity in the online ferrograph sensor. On this basis, a Mask-RCNN-based segmentation model of particle chains is constructed by specifically establishing the region of interest (ROI) generation layer and the ROI align layer for the irregular particle morphology. With these measures, a new online ferrograph sensor is designed to enhance the image acquisition and information extraction of wear particles. For verification, the developed sensor is tested to collect particle images from different degraded oils, and the images are further handled with the Mask-RCNN-based model for particle feature extraction. Experimental results reveal that the optimized online ferrography can capture clear particle images even in highly-degraded lubricant oils, and the illumination uniformity reaches 90% in its imaging field. Most importantly, the statistical accuracy of wear particles has been improved from 67.2% to 94.1%.
Scuffing failure analysis based on a multiphysics coupling model and experimental verification
Authors: Lyu Bugao , Meng Xianghui , Yin Jiabao , Cui Yi , Wang Chengen 
Published: December 2023

AbstractGeneral reductions in lubricant viscosities and increasing loads in machine components highlight the role of tribofilms in providing surface protection against scuffing. However, the relationship between the scuffing process and the growth and removal of tribofilm is not well understood. In this study, a multiphysics coupling model, which includes hydrodynamic lubrication, asperity contact, thermal effect, tribochemistry reaction, friction, and surface wear, was developed to capture the initiation of surface scuffing. Simulations and experiments for a piston ring and cylinder liner contact were conducted following a step-load sequence under different temperature conditions. The results show that high temperature and extreme load could induce the lubricant film collapse, which in turn triggers the breakdown of the tribofilm due to the significantly increased removal process. The failures of both lubricant film and tribofilm progress instantaneously in a coupling way, which finally leads to severe scuffing.
Ultraviolet-Irradiated All-Organic Nanocomposites with Polymer Dots for High-Temperature Capacitive Energy Storage
Authors: Ding Jiale , Zhou Yao , Xu Wenhan , Yang Fan , Zhao Danying , Zhang Yunhe , Jiang Zhenhua , Wang Qing 
Published: December 2023

AbstractPolymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems. While inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers, the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film processing. Herein, zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone) to form the all-organic polymer composites for high-temperature capacitive energy storage. Upon ultraviolet irradiation, the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures, which significantly reduces the high-field energy loss of the composites at 200 °C. Accordingly, the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm−3 at 200 °C. Along with outstanding cyclic stability of capacitive performance at 200 °C, this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites.
Primary Austenite Morphology and Tensile Strength in CGI for Different C Contents, Cooling Conditions and Nodularity
Authors: Fourlakidis Vasilios , Hernando Juan Carlos , Diószegi Attila 
Published: December 2023

AbstractCompacted graphite iron (CGI) is a good option for the blocks and cylinder heads in heavy duty engines due to their well-balanced thermal and mechanical properties. In this work, a remelting technique has been utilized for the production of CGI with different nodularity (10 and 20%), C contents (CE=3.5, 3.8, 4.2) and under different solidification and cooling rates. The employed experimental parameters had a sizeable influence on the morphology and fraction of the inter-dendritic structure and resulted in ultimate tensile strength (UTS) that ranged from 335 to 456 MPa and 371 to 521 MPa for the 10 and 20% nodularity, respectively. The results show that the UTS is linearly related to the solidification time and the microstructural parameter that express the scale length of the inter-dendritic region. Different CE and nodularity provide different relationships between UTS, solidification time and microstructure. Finally, an empirical model has been developed for the prediction of the UTS.
Assessing the Yuli surface deformation from the 20220918 Chishang earthquake: an integrated RTK GNSS network approach
Authors: Widiatmoko Fajar Rizki , Yen Jiun-Yee , Yen I-Chin , Huang Shao-Yi , Shih Nai-Wun 
Published: December 2023

AbstractThe 20220918 Chishang earthquake impacted the Yuli area in the Longitudinal Valley of eastern Taiwan. Longitudinal Valley is situated near the boundary of the Philippine Plate and Eurasian Plate boundary with frequent seismicity and historical earthquakes. This study uses RTK GNSS measurements to characterize the 0918 seismic effects, revealing different coseismic displacement patterns in the Central Range, Coastal Range, and Longitudinal Valley blocks. Ruptures were mainly in the Longitudinal Valley, extending into downtown Yuli township. The influence on these geological formations highlights the complex interactions between the structures and underlying tectonic forces. Our investigations show that the Central Range block experienced a 1.17 m SW horizontal displacement and 1.1 m vertical uplift, while the Coastal Range block displayed a 1.18 m NW horizontal displacement and 0.65 m subsidence. The Longitudinal Valley block was divided by recent ruptures, with its western part impacted by the Central Range block, experiencing a 0.79 m SW displacement and 0.63 m uplift, and its eastern part influenced by the Coastal Range block, experiencing a 1.02 m NW displacement and 0.13 m subsidence. Our data indicates that different blocks were all affected differently, reflecting complex relationships between the subsurface faults to the surface fault traces. The result suggests the Central Range Fault have triggered the Yuli Fault for west-side up motion and possess a westward dip connected to the Central Range Fault. The post-seismic surveys reveal complex interactions between the Central Range and Longitudinal Valley Faults, vital for advancing earthquake mitigation strategies.
‘Vaccines are for children only’? Some institutional roots of popular scepticism about vaccines for COVID-19 in Sierra Leone
Authors: Mokuwa Esther Yei 
Published: December 2023

Abstract
Vaccines for COVID-19 began to be available in Africa from mid-2021. This paper reports on local reactions to the possibility of vaccination in one West African country, Sierra Leone. We show that the history of institutionalisation of vaccine is highly relevant to understanding these reactions. Given lack of testing for the disease, medical authorities could not be sure whether there was a hidden epidemic. In addition, many people associate vaccination with care of children under 5 years, and not adults, and an emphasis on vaccinating the old at first seemed strange and worrying. This paper examines evidence from ethnographic studies in two rural areas selected for varying exposure to Ebola Virus Disease (EVD), supplemented by some interviews in two provincial urban centres, Bo and Kenema. We describe local ideas about vaccination (maklet) and body marking with leaf medicine (tεwi). We asked about attitudes to the idea of COVID-19 vaccination both before and after vaccines were available. A number of reasons were given for scepticism and hesitation. These included lack of experience with vaccines for adults and lack of experience of COVID-19 as a severe disease. Medical evidence suggests the vaccination protects against serious illness, but local people had their own views about control of infection, based both recent experience (notably EVD) and the history and institutionalisation of vaccination and public health measures in Sierra Leone more broadly.
Minding Creation: an overview
Authors: Leidenhag Joanna 
Published: December 2023

AbstractThe doctrine of creation is a teaching shared across many faith traditions that requires urgent interdisciplinary attention today. Joanna Leidenhag's book Minding Creation considers how the philosophy of panpsychism might be beneficial to the Christian articulation of creation. This article is an overview of the book, in order to contextualize the four responses and author's reply that follows.
‘From all quarters of the Indian world’: the temple at Rameshvaram, Hindu kings, and Dutch merchants
Authors: Bes Lennart , Branfoot Crispin 
Published: December 2023

AbstractOn Rameshvaram island in the south-east corner of India lies one of Hinduism's most important temples—the Rāmanāthasvāmi, one of the four dhams (‘holy abodes’) and the site of two Śiva-liṅgas said to have been consecrated by Rāma himself. A temple has existed here since at least the eleventh century, although most of the present temple dates to the seventeenth and eighteenth centuries when the island was protected by the Setupati rulers of nearby Ramnad. In several of the long corridors and halls for which this temple is famous are brightly painted life-sized standing images of over 100 male figures attached to columns. Though such images are characteristic of many south Indian temples from the seventeenth and eighteenth centuries, there are far more at Rameshvaram than at any other south Indian temple. This article examines the number, location, and significance of these numerous standing images within this temple. By exploring the significance of the temple as a long-standing site for the royal performance of devotion, this article seeks to address whether the great number and identity of the life-sized donor images can be explained by both Purāṇic ideas of kingship and seventeenth- and eighteenth-century Dutch observations of the pan-Indian status of the temple.
New Zealand household purchases of sugar-sweetened, artificially sweetened, and unsweetened beverages: 2015–2019
Authors: Eyles Helen , Dodd Sah , Garton Kelly K , Jiang Yannan , Gontijo de Castro Teresa 
Published: December 2023

Abstract

Objective:
To assess annual household purchases of sugar-sweetened beverages (SSBs), artificially sweetened beverages (AFSBs), and unsweetened beverages (USBs) by household composition and income, and over time.

Design:
Observational cohort study using beverage purchasing data linked to a supermarket database. ANOVA was used to compare total household purchase volumes (L) and the contribution of beverages purchased by category, household composition (size), household income (four categories from New Zealand (NZ) < $30 000 to > $90 000), and over time (trend from 2015 to 2019).

Setting:
Aotearoa NZ.

Participants:
∼1800 households in the NielsenIQ Homescan® market research panel.

Results:
In 2019, the mean (sd) annual household purchase volume and relative contribution to total beverage volume of SSBs were 72·3 (93·0) L and 33 %, respectively. Corresponding values for AFSBs were 32·5 (79·3) L (15 %), and USBs were 112·5 (100·9) L (52 %). Larger households purchased more of all beverage types except AFSBs. Total purchases were similar by income, but households earning < $NZ 30 000 purchased fewer AFSBs and USBs (but not SSBs) than households earning > $NZ 90 000. Total and USB purchases were unchanged over time, but SSBs dropped by 5·9 L (P-trend = 0·04), and AFSBs increased by 5·3 L (P-trend = 0·00).

Conclusions:
USBs contributed the most to household beverage purchases. Total purchases were higher for larger households and similar by income, including for SSBs. The reduction over time was too small for health benefits. Findings support policies and interventions to reduce SSB consumption and highlight the importance of focusing on equitable outcomes.