bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of severe infection associated with immunoglobulin deficiency under rituximab therapy in immune-mediated inflammatory disease
Authors: Rempenault Claire , Lukas Cédric , Tardivon Léa , Daien Claire Immediato , Combe Bernard , Guilpain Philippe , Morel Jacques 
Published: January 2024

ObjectivesWe evaluated the risk of severe infection in patients with immune-mediated inflammatory disease (IMID) treated with RTX and with Ig deficiency.MethodsThis was an observational, retrospective single-centre study of patients undergoing treatment with at least one rituximab (RTX) infusion for an IMID until 31 May 2020. Patients were followed up for at least 12 months after the last infusion or until severe infection or death. Ig deficiency was classified as prevalent (before RTX) or acquired (normal Ig assay results before RTX but Ig deficiency during a follow-up).ResultsOf 311 patients, 10.6% had prevalent and 19.6% acquired Ig deficiency. Prevalent Ig deficiency was related to concomitant treatment with glucocorticoids (GCs), in particular with a high daily dose at baseline; and acquired Ig deficiency to cumulative dose of RTX, mean Disease Activity Score in 28 joints (DAS28), immunosuppressor or GCs therapy at baseline, diabetes mellitus and obesity. Overall, 14.5% of patients had a severe infection during follow-up, which was numerically but not statistically more frequent in patients with prevalent Ig deficiency than normal Ig level. On multivariate analysis, risk of severe infection was associated with chronic pulmonary disease, GCs dose and mean DAS28-C reactive protein. In a time-dependent analysis, risk of severe infection was not associated with Ig deficiency, either acquired or prevalent (adjusted HR 1.04 (95% CI 0.5 to 2.3), p=0.92).ConclusionRisk of severe infection was not associated with RTX-induced Ig deficiency in patients with an IMID. RTX management should be discussed according to an individual assessment of the infectious risk, especially in patients with GC therapy or chronic lung disease.
Dynamics of inflammation-associated plasma proteins following faecal microbiota transplantation in patients with psoriatic arthritis and healthy controls: exploratory findings from the FLORA trial
Authors: Kragsnaes Maja Skov , Jensen Jennifer Rugaard Bregndahl , Nilsson Anna Christine , Malik Muhammad Irfan , Munk Heidi Lausten , Pedersen Jens Kristian , Horn Hans Christian , Kruhøffer Mogens , Kristiansen Karsten , Mullish Benjamin H , Marchesi Julian R , Kjeldsen Jens , Röttger Richard , Ellingsen Torkell 
Published: January 2024

ObjectivesThe gut microbiota can mediate both pro and anti-inflammatory responses. In patients with psoriatic arthritis (PsA), we investigated the impact of faecal microbiota transplantation (FMT), relative to sham transplantation, on 92 inflammation-associated plasma proteins.MethodsThis study relates to the FLORA trial cohort, where 31 patients with moderate-to-high peripheral PsA disease activity, despite at least 3 months of methotrexate treatment, were included in a 26-week, double-blind, randomised, sham-controlled trial. Participants were allocated to receive either one gastroscopic-guided healthy donor FMT (n=15) or sham (n=16). Patient plasma samples were collected at baseline, week 4, 12 and 26 while samples from 31 age-matched and sex-matched healthy controls (HC) were collected at baseline. Samples were analysed using proximity extension assay technology (Olink Target-96 Inflammation panel).ResultsLevels of 26 proteins differed significantly between PsA and HC pre-FMT (adjusted p<0.05), of which 10 proteins were elevated in PsA: IL-6, CCL20, CCL19, CDCP1, FGF-21, HGF, interferon-γ (IFN-γ), IL-18R1, monocyte chemotactic protein 3, and IL-2. In the FMT group, levels of 12 proteins changed significantly across all timepoints (tumour necrosis factor (TNF), CDCP1, IFN-γ, TWEAK, signalling lymphocytic activation molecule (SLAMF1), CD8A, CD5, Flt3L, CCL25, FGF-23, CD6, caspase-8). Significant differences in protein levels between FMT and sham-treated patients were observed for TNF (p=0.002), IFN-γ (p=0.011), stem cell factor (p=0.024), matrix metalloproteinase-1 (p=0.038), and SLAMF1 (p=0.042). FMT had the largest positive effect on IFN-γ, Axin-1 and CCL25 and the largest negative effect on CCL19 and IL-6.ConclusionsPatients with active PsA have a distinct immunological plasma protein signature compared with HC pre-FMT. FMT affects several of these disease markers, including sustained elevation of IFN-γ.Trial registration numberNCT03058900.
Sex differential impact of comorbidities in spondyloarthritis: data from COMOSPA study
Authors: Llop Maria , Gratacós Jordi , Moreno Mireia , Arevalo Salaet Marta , Calvet Joan , Berenguer-Llergo Antoni , Dougados Maxime , Molto Anna , López-Medina Clementina 
Published: January 2024

ObjectivesTo describe and compare the prevalence of comorbidities in female and male patients with spondyloarthritis (SpA) and to assess whether comorbidities had a different impact on disease outcomes in male and female patients.MethodsThis is a post hoc analysis of the COMOrbidities in SPondyloArthritis study. Differences in comorbidities regarding sex were assessed using logistic regression models. Comorbidities were evaluated for their impact on disease outcomes (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Functional Index, European health-related quality of life questionnaire) with linear models, which included sex and comorbidity as explanatory variables and their interaction. Age and treatment with biological synthetic disease-modifying antirheumatic drugs were included as confounders.ResultsWe included 3982 patients with SpA (65% male, mean age 43.6 years). Male and female patients with SpA exhibited similar comorbidity profiles, except for a low prevalence of fibromyalgia in males and a higher prevalence of certain cardiovascular risk factors in males (hypertension, dyslipidaemia, renal impairment and ischaemic heart disease). Comorbidities, especially fibromyalgia, correlated with higher disease activity, decreased physical function and reduced health-related quality of life in both sexes. Some comorbidities exhibited sex-specific associations with disease outcomes. Peptic ulcers and high waist circumference had a greater impact on disease activity in females (with a higher impact in BASDAI than in ASDAS). In contrast, osteoporosis had a more pronounced effect on physical function in male patients.ConclusionsComorbidities exert distinct influences on disease activity, physical function and health-related quality of life in male and female patients with SpA. Understanding these sex-specific effects is crucial for improving SpA management, emphasising the importance of assessing disease activity using ASDAS when comorbidities are present to mitigate sex-related disparities in disease assessment.
Searching for sbottom LSP at the LHC
Authors: Knees Paulina , Kpatcha Essodjolo , Lara Iñaki , López-Fogliani Daniel E. , Muñoz Carlos 
Published: January 2024

AbstractAssuming that the sbottom is the lightest supersymmetric particle (LSP), we carry out an analysis of the relevant signals expected at the LHC. The discussion is established in the framework of the $$\mu \nu $$

μ
ν

SSM, where the presence of R-parity violating couplings involving right-handed neutrinos solves simultaneously the $$\mu $$
μ
-problem and the accommodation of neutrino masses and mixing angles. The sbottoms are pair produced at the LHC, decaying to a lepton and a top quark or a neutrino and a bottom quark. The decays can be prompt or displaced, depending on the regions of the parameter space of the model. We focus the analysis on the right sbottom LSP, since the left sbottom is typically heavier than the left stop because of the D-term contribution. We compare the predictions of this scenario with ATLAS and CMS searches for prompt and long-lived particles. To analyze the parameter space we sample the $$\mu \nu $$

μ
ν

SSM for a right sbottom LSP, paying special attention to reproduce the current experimental data on neutrino and Higgs physics, as well as flavor observables. For displaced (prompt) decays, our results translate into lower limits on the mass of the right sbottom LSP of about 1041 GeV (1070 GeV). The largest possible value found for the decay length is about 3.5 mm.
Time-discrete momentum consensus-based optimization algorithm and its application to Lyapunov function approximation
Authors: Ha Seung-Yeal , Hwang Gyuyoung , Kim Sungyoon 
Published: January 2024

In this paper, we study a discrete momentum consensus-based optimization (Momentum-CBO) algorithm which corresponds to a second-order generalization of the discrete first-order CBO [S.-Y. Ha, S. Jin and D. Kim, Convergence of a first-order consensus-based global optimization algorithm, Math. Models Methods Appl. Sci. 30 (2020) 2417–2444]. The proposed algorithm can be understood as the modification of ADAM-CBO, replacing the normalization term by unity. For the proposed Momentum-CBO, we provide a sufficient framework which guarantees the convergence of algorithm toward a global minimum of the objective function. Moreover, we present several experimental results showing that Momentum-CBO has an improved success rate of finding the global minimum compared to vanilla-CBO and show the stability of Momentum-CBO under different initialization schemes. We also show that Momentum-CBO can be used as the alternative of ADAM-CBO which does not have a proper convergence analysis. Finally, we give an application of Momentum-CBO for Lyapunov function approximation using symbolic regression techniques.
Phase I Study of GS-3583, an FMS-like Tyrosine Kinase 3 Agonist Fc Fusion Protein, in Patients with Advanced Solid Tumors
Authors: Tolcher Anthony W. , Brody Joshua D. , Rajakumaraswamy Nishanthan , Kuhne Michelle , Trowe Torsten , Dauki Anees M. , Pai Shantheri , Han Ling , Lin Kai-Wen , Petrarca Michael , Kummar Shivaani 
Published: January 2024

Abstract

Purpose:
GS-3583, an FMS-like tyrosine kinase 3 (FLT3) agonist Fc fusion protein, expanded conventional dendritic cells (cDC) in the periphery of healthy volunteers, suggesting potential for GS-3583 to increase cDCs in the tumor microenvironment and promote T cell–mediated antitumor activity in cancer patients. This phase Ib open-label study assessed GS-3583 in adults with advanced solid tumors.

Patients and Methods:
Multiple escalating doses of GS-3583 (standard 3+3 design) were administered intravenously on days 1 and 15 of cycle 1 and day 1 of each subsequent 28-day cycle for up to 52 weeks. Dose-limiting toxicity (DLT) was evaluated during the first 28 days of GS-3583 at each dose level.

Results:
Thirteen participants enrolled in four dose-escalation cohorts, after which the study was terminated following safety review. Median (range) age was 71 (44–79), and 7 (54%) participants were male. There were no DLTs. Seven participants had grade ≥3 AEs; 2 participants had grade 5 AEs, including a second primary malignancy (acute myeloid leukemia) considered treatment-related. Dose-dependent increase in GS-3583 serum exposure was observed in the dose range of 2–20 mg with GS-3583 accumulation at higher dose levels. Expansions of cDCs occurred at all four doses with a dose-dependent trend in the durability of the cDC expansion.

Conclusions:
GS-3583 was relatively well tolerated and induced dose-dependent expansion of cDCs in the periphery of patients with advanced solid tumors. However, development of a second primary malignancy provides a cautionary tale for the FLT3 agonist mechanism.
See related commentary by Raeder and Drazer, p. 2857
Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional‐Based Italian Database
Authors: Tikhonoff Valérie , Casiglia Edoardo , Virdis Agostino , Grassi Guido , Angeli Fabio , Arca Marcello , Barbagallo Carlo M. , Bombelli Michele , Cappelli Federica , Cianci Rosario , Cicero Arrigo F. G. , Cirillo Massimo , Cirillo Pietro , Dell'oro Raffaella , D'elia Lanfranco , Desideri Giovambattista , Ferri Claudio , Galletti Ferruccio , Gesualdo Loreto , Giannattasio Cristina , Iaccarino Guido , Mallamaci Francesca , Maloberti Alessandro , Masi Stefano , Masulli Maria , Mazza Alberto , Mengozzi Alessandro , Muiesan Maria Lorenza , Nazzaro Pietro , Palatini Paolo , Parati Gianfranco , Pontremoli Roberto , Quarti‐Trevano Fosca , Rattazzi Marcello , Reboldi Gianpaolo , Rivasi Giulia , Russo Elisa , Salvetti Massimo , Temporelli Pier Luigi , Tocci Giuliano , Ungar Andrea , Verdecchia Paolo , Viazzi Francesca , Volpe Massimo , Borghi Claudio 
Published: January 2024

Background
Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, the exact level at which risk begins to rise is unclear. The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension has conceived a protocol aimed at searching for the prognostic cutoff value of triglycerides in predicting cardiovascular events in a large regional‐based Italian cohort.

Methods and Results

Among 14 189 subjects aged 18 to 95 years followed‐up for 11.2 (5.3–13.2) years, the prognostic cutoff value of triglycerides, able to discriminate combined cardiovascular events, was identified by means of receiver operating characteristic curve. The conventional (150 mg/dL) and the prognostic cutoff values of triglycerides were used as independent predictors in separate multivariable Cox regression models adjusted for age, sex, body mass index, total and high‐density lipoprotein cholesterol, serum uric acid, arterial hypertension, diabetes, chronic renal disease, smoking habit, and use of antihypertensive and lipid‐lowering drugs. During 139 375 person‐years of follow‐up, 1601 participants experienced cardiovascular events. Receiver operating characteristic curve showed that 89 mg/dL (95% CI, 75.8–103.3, sensitivity 76.6, specificity 34.1,
P
<0.0001) was the prognostic cutoff value for cardiovascular events. Both cutoff values of triglycerides, the conventional and the newly identified, were accepted as multivariate predictors in separate Cox analyses, the hazard ratios being 1.211 (95% CI, 1.063–1.378,
P
=0.004) and 1.150 (95% CI, 1.021–1.295,
P
=0.02), respectively.

Conclusions
Lower (89 mg/dL) than conventional (150 mg/dL) prognostic cutoff value of triglycerides for cardiovascular events does exist and is associated with increased cardiovascular risk in an Italian cohort.
Comparison of Effectiveness Among Different Sodium‐Glucose Cotransoporter‐2 Inhibitors According to Underlying Conditions: A Network Meta‐Analysis of Randomized Controlled Trials
Authors: Kani Ryoma , Watanabe Atsuyuki , Miyamoto Yoshihisa , Ejiri Kentaro , Iwagami Masao , Takagi Hisato , Slipczuk Leandro , Tsugawa Yusuke , Aikawa Tadao , Kuno Toshiki 
Published: January 2024

Background
To investigate the individual profile of each SGLT2 (sodium‐glucose cotransoporter‐2) inhibitor in patients with different backgrounds.

Methods and Results
This study included 21 placebo‐controlled randomized controlled trials with a total of 96 196 participants, investigating empagliflozin, ertugliflozin, dapagliflozin, canagliflozin, and sotagliflozin. The primary efficacy end point was the composite of cardiovascular death and hospitalizations for heart failure. The secondary efficacy end points were all‐cause death, cardiovascular death, hospitalizations for heart failure, kidney disease progression, and acute kidney injury. We conducted subgroup analyses based on the underlying comorbidities, including diabetes and chronic kidney disease. Safety end points were also assessed among SGLT2 inhibitors in the overall cohort. In the overall cohort, there were no significant differences in the primary efficacy outcome among the SGLT2 inhibitors, while empagliflozin (hazard ratio [HR], 0.70 [95% CI, 0.53–0.92]) and dapagliflozin (HR, 0.73 [95% CI, 0.56–0.96]) were associated with lower risk of acute kidney injury than sotagliflozin. The presence or absence of diabetes did not alter the results. In patients with chronic kidney disease, there were no differences in the efficacy outcomes among SGLT2 inhibitors, while in patients without chronic kidney disease, empagliflozin was associated with lower risk of the primary outcome compared with ertugliflozin (HR, 0.77 [95% CI, 0.60–0.98]). For safety outcomes, no significant differences were observed in amputation, urinary tract infection, genital infection, hypoglycemia, and diabetic ketoacidosis.

Conclusions
The differences in reducing cardiovascular and kidney outcomes as well as safety profiles across SGLT2 inhibitors were not consistently significant, although empagliflozin might be preferred in patients without chronic kidney disease. Further investigations are needed to better understand the mechanism and clinical effectiveness of each SGLT2 inhibitor in certain populations.
The Aqedah (Gen 22:1–19) and Euripides’s Iphigenia in Aulis
Authors: Kozlowski Jan M. , Poloczek Sławomir 
Published: January 2024

Abstract
Scholars have long recognized the narrative similarities between the story of the Aqedah (Gen 22:1–19) and Euripides’s Iphigenia in Aulis. The aim of this paper is to present the most plausible explanation of the similarities between these narratives: Aqedah’s dependence upon Euripides’s tragedy.
Evaluating the Categorical Exclusion of Khasi Women from Inheritance and Property Rights
Authors: Singh Jyoti , Bhatnagar Kajori 
Published: January 2024

Abstract
Customary laws govern inheritance among many tribal communities that fall within the ambit of the fifth and sixth schedules of the Indian Constitution. Under this paper’s scope, we shall look at the Khasi community hailing from the state of Meghalaya which is a matrilineal community. Where the Khasis draw their lineage from their mothers, there is a misnomer that women inherit and own the entire property. In light of the abovementioned background, the paper makes an analytical study of the customary inheritance rights of Khasi women, the nature of resource ownership and attempts to understand the grounds behind the claims of gender preference in the existing matrilineal system practised by the Khasis of Meghalaya. We also look at the intersection of gender and matrilineal system of inheritance in the Khasi community, the dispute between customs and legislations and examine whether there exists a need for codification. The paper also discusses the findings of the survey and focus group discussions including 90 Khasi women from East Khasi Hills and their growing consensus on equal inheritance rights but resistance towards statutory laws to govern their lives.
Human Right Violation Through State Terrorism in Indonesia
Authors: Liem Justiani , Kadi Saurip , Neonbasu Gregorius 
Published: January 2024

Abstract
Indonesia is essentially pluralistic and multicultural. As a diverse country, Indonesia has the largest number of Muslim adherents in the world. The country commits itself on religious tolerance, democratic transformation, and the promotion of human rights. However, many Indonesians face religious discrimination. Laws, policies, and practices contrary to international human rights continue, and the State has been failing to protect its citizens from religious intolerance and violence. Concentration of power, wealth in the hand of oligarchy has caused state terrorism and capital violence. People’s initiatives to solve their own daily lives can be easily crushed. This paper chooses the case of Gafatar to show how state apparatus executed Three Ministerial Decrees as the legal justification of violence to its citizens, besides The Indonesian Council of Religious Scholars banned the Millah Abraham’s teaching, and until today, The Government has not revised it. Indonesia’s commitment to human dignity and harmony is questioned.
Desire, Marriage, and Overpopulation: The Sexual Lives of Insects in the Enlightenment (Tome 145, 7e Série, n°1-2, (2024))
Authors: Lidwell-Durnin John , Roy-di Piazza Vincent 
Published: January 2024

Abstract
During the eighteenth century, the discovery of sexual reproduction in insect species prompted the demise of spontaneous generation and new developments in natural history, theology, and political economy. The sexual lives of insects prompted debates on whether insects were governed by desire, free will, and even marital tendency. Fuelled by the democratisation of microscopy, early modern entomology took a new turn and breadth: the study of insects and of their sexual lives provided unexpected new insights into human sexuality, reproduction, and Malthusian fears of overpopulation. This article surveys the intellectual culture of entomology and natural history during the crucial decades when entomologists worked to quantify the reproductive capacities of insect species. Assessing the influences these entomological works had within political economy and theology, we argue that the sexual lives of insects − once analysed and delineated − influenced familiar ideological features of the intellectual landscape of the late Enlightenment, particularly in the theological philosophies of northern Europe and in the political economy of population in Britain.
The Near-Infrared Airglow Camera on the International Space Station
Authors: Gelinas L. J. , Hecht J. H. , Rudy R. J. 
Published: January 2024

Abstract
The OH airglow layer is a persistent feature of Earth’s upper mesosphere, centered near 87 km altitude, that can be perturbed by atmospheric gravity waves (AGWs) and instabilities. While ground-based airglow imaging has been used to study these perturbations locally, this technique is limited by tropospheric weather. Space-based remote sensing provides a platform to measure these processes globally. In addition, portions of the OH airglow band span an atmospheric window, allowing airglow illumination of the ground for imaging of nighttime clouds and Earth terrain features. The Near-Infrared Airglow Camera (NIRAC) images the airglow at 1.6 μm and while deployed to the International Space Station (ISS) from May 2019 to November 2021 demonstrated these applications. The camera uses a patented motion-compensation system with a custom rectilinear lens that allows multisecond, nearly smear-free imaging (∼<1.5 pixels) at a ground pixel resolution of ∼83 m. With a ∼170 km × 170 km ground swath, NIRAC acquires overlapping images at a 7–10-s cadence. Parallax considerations enable detection of both AGWs and instabilities in the airglow, and scenes can be analyzed for terrain and cloud height. NIRAC also has a short-exposure daytime mode for cloud and ground imagery. This study describes NIRAC and its operations on the ISS and presents imagery examples of Earth terrain and surface phenomenology (such as fires), cloud imagery at all moon phases day and night, and the nighttime detection of AGWs and instabilities above 80 km altitude.

Significance Statement
The Near-Infrared Airglow Camera (NIRAC) is the first space-based instrument to exploit the bright 1.6 μm OH Meinel airglow emission band for Earth surface imager at resolution of ∼83 m. During its 2.5-yr deployment on the International Space Station (ISS), NIRAC obtained over a half million images of Earth’s surface and OH airglow layer. NIRAC has been able to capture images of the very small-scale (<30 km) AGWs and instabilities under a wide range of viewing conditions, including (i) in the vicinity of city lights, (ii) over complex cloud scenes, and (iii) under both moondown and moonup illumination. NIRAC also acquired daytime and nighttime images of clouds, hurricanes and typhoons, human lighting, and forest fires in the 1.6 μm band.