bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 on medical students well-being and psychological distress
Authors: Tyagi Kashish , Chaudhari Bhushan , Ali Tahoora , Chaudhury Suprakash 
Published: January 2024

Background:
Mental well-being is important for medical students to perform effectively. The COVID-19 pandemic posed different stressors to medical students increasing their vulnerability to distress and impaired well-being.

Aim:
To assess the effect of the COVID-19 pandemic on the well-being of medical students and its relation with COVID-related psychological distress and fear as well as sleep quality.

Materials and Methods:
We planned a cross-sectional study on medical students with the help of an online Google Form including sociodemographic data, medical students well-being index (MSWBI), Psychological Distress Scale, fear of COVID-19 Scale (FCV-19S), and Pittsburgh Sleep Quality Index (PSQI).

Results:
48.13% of students reported higher distress and impaired mental well-being. Impaired well-being is correlated with COVID-related psychological distress, fear of COVID-19, and disturbed sleep quality. Regression analysis showed that joint family and sleep disturbances significantly predicted distress or poor well-being in medical students.

Conclusion:
Almost half of the medical students revealed impaired mental well-being underlining the role of COVID-related stressors in worsening the psychological health of students. In this situation, it is important to take prompt measures to identify vulnerable students and help them.
The correlation between pre-treatment CEA levels and the EGFR mutation status in advanced lung adenocarcinoma
Authors: Uysal Mukremin , Beypinar Ismail , Araz Murat 
Published: January 2024

ABSTRACT

Background:
The discovery of the epidermal growth factor receptor (EGFR) mutation, especially in adenocarcinoma, has led to a major change in the treatment of non-small-cell lung cancer (NSCLC). This study investigated the relationship between the EGFR mutation status and the carcinoembryonic antigen (CEA) levels at the time of diagnosis.

Materials and Methods:
A total of 102 patients with EGFR mutation and tested CEA levels were recruited for this study. Of the patients, 24 were EGFR mutants (23.5%), while 78 patients (76.5%) did not harbor any EGFR mutations.

Results:
The CEA levels did not differ across groups. Additionally, the CEA levels were analyzed between female and male patients separately due to EGFR mutations; no difference was observed. When the CEA levels were categorized as positive or negative based on different cut-off values, such as 5 and 10 ng/ml, no statistical difference was found between groups.

Conclusion:
In this study, no relationship between EGFR mutation and pre-treatment CEA levels was observed. Despite positive trials having shown a predictive value of CEA levels for EGFR mutation, more clinical trials are needed to elucidate the racial, clinical, and pathological differences of the study populations. Most studies have been located in the Far East, but new trials in Caucasian, African, and Hispanic populations are still lacking.
Volumetric and geometric changes in the parotid glands and target volume during image-guided radiotherapy for locally advanced oropharyngeal cancers
Authors: Gayakwad Sagar , Budrukkar Ashwini , Murthy Vedang , Laskar Sarbani G. , Upreti Ritu Raj , Upreti Udita , Gupta Tejpal , Agarwal Jai Prakash 
Published: January 2024

ABSTRACT

Purpose:
This study aimed to evaluate the volumetric and geometric changes in the parotid glands and target volume during image-guided radiotherapy (IGRT) for locally advanced oropharyngeal cancers.

Materials and Methods:
Twenty patients receiving radiotherapy using IGRT at a dose of 70 Gy/35 fractions/7 weeks for locally advanced oropharyngeal cancers were accrued. Radiotherapy planning computed tomography (CT) scans were performed at pre-radiotherapy (RT), 20, 40, and 60 Gy for each patient. Volume changes in target and parotids along with shifts of parotids were assessed with respect to pre-RT scan after co-registration. In study scans, GTVp and GTVn were recontoured as per particular CT. CTV and PTV were copied from planning CT to study CT. CTV was edited from anatomical barriers, and PTV was edited only from the skin in the study CT. The parotids were recontoured on each study scan. The center of mass (COM) of C2 vertebral body was considered as the reference to evaluate its shifts.

Results:
There was a statistically significant percentage regression of ipsilateral and contralateral parotid mean volumes at the rate of 0.85%/0.207 cc and 0.98%/0.26 cc per day, respectively. We observed the mean medial shift of center of mass of ipsilateral parotid of 2.23 mm (p = 0.011) and contralateral parotid of 2.67 mm (p = 0.069) at the end of 60 Gy. GTVp (mean) reduced from 41.87 cc at 0 Gy to 31.13 cc (25.65%) at 60 Gy (p = 0.003), while GTVn (mean) reduced from 19.98 cc at 0 Gy to 10.79 cc (45.99%) at 60 Gy (p = 0.003). There was a statistically significant reduction in CTV and PTV volumes at 60 Gy.

Conclusion:
Statistically significant volumetric and geometric changes occurred during intensity-modulated radiation (IMRT), which were most prominent after 40 Gy and were maximum at 60 Gy. There was a medial shift of parotid glands toward the high-dose region. This study can be useful to devise an adaptive radiotherapy strategy.
Utility of guided FNAC and cell block preparation from liver and gall bladder masses: Learning experience from a tertiary care center
Authors: Bohara Sangita , Shukla Prakriti , Shah Saman , Chaturvedi Rashmi , Singh Kushal 
Published: January 2024

ABSTRACT

Introduction:
Ultrasound- and CT-guided fine needle aspiration cytology (FNAC) increases the accessibility of intra-abdominal masses to the liver and gall bladder with the advantages of low cost and high diagnostic yield. Cell block technique has been known for further increasing the diagnostic accuracy.

Aims and Objectives:
We aimed to study the effectiveness of FNAC and the cell block method in cytological diagnosis of liver and gall bladder masses. We also followed a step-wise approach to increase the success rate.

Materials and Methods:
A 2-year observational study was done from July 2020 to June 2022. Total 80 guided (CT and ultrasound) aspirations were done from space occupying/mass lesions in the liver [74 (92.5%)] and gall bladder [6 (7.5%)], out of which cell blocks by the plasma thrombin method were prepared in 12 cases (15%). The on-site radiological details were noted, and rapid on-site evaluation was done in 65 cases (81.25%). The prepared cytology slides were stained with Papanicolaou, H and E and May-Grunwald Giemsa (MGG) stain. The cytological diagnosis was noted, and the uses and limitations (if any) were observed in each case. A step-wise structured questionnaire format was developed to assist the reporting pathologist so as not to miss out on important diagnostic observations, if present.

Results:
FNAC in 71 cases (88.7%) gave a conclusive diagnosis. The maximum number of cases were of adenocarcinoma [38 (51.3%)] from the liver followed by hepatocellular carcinoma in 10 cases (13.5%). In gall bladder masses, all 6 cases (100%) were positive for malignancy, out of which 4 cases (66.7%) could be characterized as adenocarcinoma. The cell block preparation was helpful in reaching the diagnosis as well as typing the malignancy in 10 cases (83.3%). The chief limitation observed on conventional cytology smears was inadequate cellularity, which caused inconclusive diagnosis in 9 cases (11.25%). The reporting questionnaire was helpful chiefly in terms of time-efficient reporting in 34 cases (42.5%), increasing the ease and confidence in 69 cases (86.25%) and the advantage of reproducibility of data in all cases (100%) according to the case-by-case evaluation by the reporting pathologists.

Conclusion:
Guided FNAC in conjunction with the cell block technique is extremely helpful in the evaluation of mass lesions of the liver and gall bladder for cytological diagnosis. A proper step-wise approach may be useful to reach a quick and effective diagnosis.
Pattern and trend of cancer in Saurashtra region in Gujarat state of India, a hospital-based study
Authors: Saini Surendra K. , Srivastava Shelly , Patel Pritesh , Sarvaiya Jitesh 
Published: January 2024

Background:
Cancer is growing concern for every country. Reliable data is a source to define the magnitude of the problem, which then helps to plan for necessary action. This epidemiological study involves the collection and analysis of hospital registry data to assess the quantum of the problem of cancer over a five-year period from 2012–16 and to plan priority action.

Materials and Methods:
Hospital-based data for five years from 2012–2016 was retrieved from the department of radiotherapy at M. P. Shah Government Medical College, Jamnagar, Gujarat, India, and analysed to define the magnitude of the problem. All data was studied using Microsoft Excel 2016.

Results:
A total of 7355 patients were registered between 2012 and 2016, out of which 62 percent were male. Cancers of the cervix and uterus were discernibly less common in the Saurashtra region and accounted for only 12.37% of all cancers in females. Lung cancer was the leading cancer as a single site in males (24.13% of all cancers in males) and breast cancer in females (37.36% of all cancers in females). Head and neck cancer, all sites clubbed, was most common in males (42%). Jamnagar taluka represented around 50% of all cases at the study center.

Conclusion:
Tobacco-related cancers were most common in the male population, and stringent implementation of a national tobacco control program is the most appropriate measure to curtail incidences and hence mortality in this male population. Non-modifiable risk factors like gender-related cancer were more common in the female population, and resource-appropriate screening is a suitable option for these diseases. A population-based cancer registry is required to further define the pattern pertinently, or an epidemiological study is required to find causes of the noticeably lower incidence of cancer of the cervix,.
Epithelial myoepithelial carcinoma: A case report
Authors: Kaur Ravinder , Melgandi Wineeta , Rathi Arun Kumar , Singh Kishore , Rahman Fazlu , Mandal Shramana 
Published: January 2024

ABSTRACT
Epithelial myoepithelial carcinoma is a rare tumor with the parotid gland being the most common primary site of origin. The tumor may also very rarely originate in minor salivary glands of the soft palate. Due to the rarity of its occurrence and histogenesis, clear-cut therapeutic guidelines are not defined. The present report describes the case of a 56-year-old female patient who was diagnosed to have epithelial myoepithelial carcinoma (EMC) of the minor salivary gland of the soft palate, Stage T2 N0 M0 (Stage group II). The patient was treated with radical radiotherapy followed by adjuvant chemotherapy and is alive with no evidence of disease after 12 months following the end of treatment.
Three-way Philadelphia Translocation [t(46, XX, t(9;22;16) (q34;q11.2;q24)] in Chronic Myeloid Leukemia: A Report of Two Cases with Review of the Literature
Authors: Bhardwaj Mohit , Mishra Sourav K. , Gupta Aastha , Mehta Prashant , Sharma Shivani , Mohanty Sambit K. 
Published: January 2024

ABSTRACT
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm that is genetically characterized by the presence of the Philadelphia (Ph) chromosome. Variant Ph translocation has been observed in 5% to 10% of the CML cases. In the previous studies, many different types of variant Ph translocations have been observed involving chromosomes 1p36, 3p21, 5q13, 6p21, 9q22, 11q13, 12p13, 17p13, and 10p15. According to the published literature, only two cases with the complex translocations involving long arm of chromosome 16 at band q24 have been reported. We report two female patients with complex translocation (three-way) involving chromosomes 9, 22, and 16 at breakpoint q24 and both patients responded well to Imatinib. The present study included 469 patients of clinically diagnosed CML patients who were referred for cytogenetic analysis to our laboratory. Cytogenetic analysis was performed by GTG banding, and the karyotype was designated according to the International System for Human Cytogenetic Nomenclature. Fluorescence in situ hybridization (FISH) analysis was performed for complex and variant BCR-ABL cases. Of total 469 cases, 248 patients showed classical Ph chromosome [t(9;22)(q34;q11.2)], 198 cases were normal, and 23 patients had variant and complex Ph chromosome translocation. Two patients showed three-way translocation involving long arm of chromosomes 9, 22, and 16 at band 9q34, 22q11.2, and 16q24. In this report, patients with variant Ph translocation did not have a significantly different outcome as compared to the classical translocation. Both cases responded well to Imatinib.
Investigating Pre-Columbian Gold and Copper in Costa Rica – Ores, Mines and Artefact Production
Authors: Gassmann Guntram , Klein Sabine , Schäfer Andreas , Welk Elias , Wester Katrin 
Published: January 2024

The wealth of pre-Columbian gold, copper and guanín (an alloy consisting mainly of gold and copper; also tumbaga) artwork of Costa Rica suggests that exploitation of its abundant ore deposits goes back way before the Spanish conquest. The name of Costa Rica itself in fact alludes to the large numbers of golden metal objects worn by the indigenous peoples upon arrival of the conquistadors. Up to now, however, very little is known about pre-Columbian mining in the country or the raw material provenance of these artefacts.In a transdisciplinary project, we aim to reconstruct the metallurgical process chain by combining (mining) archaeological research with geochemical analysis of local ores and metal artefacts using a combination of different techniques. We identified four major gold and copper districts with different mineralisation types, which are the focus of our fieldwork-based research. They are surveyed for potential signs of pre-Columbian metal production and sampled for ores and their processing remains. On the other side of the process chain, we focus on the metal artefacts in museum collections. They are systematically registered in a database, which serves as a basis to identify correlations with the geochemical signatures of the artefacts, and to retrace potential links to possible areas of origin or different workshops. Once the necessary basic data have been collected, we will focus on economic and socio-cultural aspects of metal production and circulation. The results from Costa Rica will be put into perspective of New World early metallurgy and can provide a starting point for future research between Mesoamerica and the Isthmo-Colombian region.
Innovación en Chile y Perú: análisis de las dimensiones del índice global de innovación
Authors: Pincheira Varas Andrea 
Published: January 2024

Con los datos recogidos del Índice Global de Innovación (GII) de la World Intellectual Property Organization (WIPO), y procesados estadísticamente a partir del procedimiento de correlación de Pearson y del análisis de comparación de medias para muestras independientes bajo la prueba t-Student, se analiza el desempeño innovador que Chile y Perú han tenido en el último quinquenio a partir del análisis de las siete dimensiones del GII. Este se compone de una serie de indicadores de insumos y de resultados, que permiten dentro de las singularidades que presentan los contextos latinoamericanos, conocer de la actividad innovadora de estas dos economías. La investigación busca aportar a la comprensión del fenómeno de la innovación en países en desarrollo de América Latina, cuyo estado del arte es aún incipiente. En términos concretos, los resultados muestran diferencias significativas tanto en el Índice Global de Innovación como en las dimensiones: Instituciones; Infraestructura; Desarrollo empresarial; Producción científica y tecnológica; y Producción creativa, más no, en el Capital humano e investigación ni en Desarrollo de mercado.
La investigación busca aportar a la comprensión del fenómeno de la innovación en países en desarrollo de América Latina, cuyo estado del arte es aún incipiente. En términos concretos, los resultados muestran diferencias significativas tanto en el Índice Global de Innovación como en las dimensiones: Instituciones; Infraestructura; Desarrollo empresarial; Producción científica y tecnológica; y Producción creativa, más no, en el Capital humano e investigación ni en Desarrollo de mercado.
Sistem Informasi Pendaftaran Pelatihan Calon Tenaga Kerja Dan Tenaga Kerja Berbasis Web
Authors: Fajar Mochamad , Lutvi Azizah Nuril , Sumarno Sumarno , Suprianto Suprianto 
Published: January 2024

The Sidoarjo District Manpower Office has the task of assisting the Sidoarjo Regent in carrying out government affairs which fall under regional authority in the field of employment. The Sidoarjo District Manpower Office manages employment data which includes data on job seekers, companies, job vacancies and job training. This still needs special attention because current employment management is not well managed, job seekers in Sidoarjo Regency still have difficulty in choosing job vacancy information. In addition, the Sidoarjo Regency Manpower Office has difficulty in preparing training programs that are in accordance with the needs of the labor market because data processing is not yet online and integrated. This research was conducted with the aim of building an Employment Management Information System application at the Sidoarjo Regency Manpower Office. It is expected that the application built by the author is able to facilitate the Sidoarjo Regency Manpower Office in managing employment data and providing the best service to residents in Sidoarjo Regency.
Keywords: Website, Information System, Sidoarjo Regency, Manpower Office.
Adaptasi Pendidikan Islam Nonformal di Era Percepatan Teknologi Informasi
Authors: Mahsun Mahsun 
Published: January 2024

Penelitian pustaka ini melihat bahwa sejarah pendidikan Islam di Nusantara sudah dimulai bersamaan dengan proses masuknya Islam dalam bentuk pendidikan nonformal. Ciri yang paling menonjol berupa materi pembelajaran keilmuan agama seperti tauhid, fiqih, tasawuf, ahlak, tafsir, dan hadis. Pembelajarannya terkonsentrasi kepada kajain kitab-kitab kuning melalui metode sorogan, wetonan dan muzakarah dengan memraktekkan sistem halaqah. Dan di era percepatan teknologi informasi (milenium ketiga) ini bertahannya pendidikan Islam nonformal memiliki tantangan kualitas, budaya dan kompetisi. Penelitian ini menggunakan content analisis sebagai teknik pengumpulan data. Sumber data diambil dari kajian tentang tema penelitian. Data yang terkumpul dilihat validitasnya dengan triangulasi sumber. Hasil penelitian menunjukkan bahwa adaptasi lembaga pendidikan Islam nonformal sebagai sebuah model pendidikan dapat mengambil bentuk pembaruan pada kualitas komponen pendidikan, penerapan nilai nilai agama menjadi nilai operasional, dan pembaruan mutu sehingga pendidikan Islam nonformal tidak ditinggalkan masyarakat.
Impact of Green Credit Incentives on Operational Decisions of Green Supply Chain
Authors: Zhan Keyu , Wu Dongxiu 
Published: January 2024

Financial incentives have been introduced to guide financial institutions to increase green credit allocation, strengthen environmental risk management, and enhance support for green and low-carbon development. This paper investigated the government’s support for the carbon-emission supply chain by implementing green credit incentives. Two financial incentives are explored: performance-based incentives and interest subsidies. We conduct game-theoretic models to examine the characteristics and effects of two financial incentives on the supply chain. Our results reveal that: (1) both incentives are effective in scaling up supply chain performance and stimulate investment in emission reduction, while the mechanism differs according to the direct beneficiaries; (2) performance-based incentives are more sensitive to environmental damage, while the optimal subsidy ratio is more sensitive to consumer green awareness, indicating that the bank has an instinctive aversion to the risks inherent in abatement investments; (3) it is optimal for the government to intervene in green credit financing activities when environmental advantages and costs and consumer green consciousness are recognized. Our conclusions suggest the government can determine financial incentives for green credit based on the stage of green transition development and the real, demanding requirements of transition goals.

Received: 7 September 2023 | Revised: 4 December 2023 | Accepted: 15 January 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
All data generated or analyzed during this study are included inthis study.

Author Contribution Statement
Keyu Zhan: Methodology, Software, Investigation, Data curation, Writing - review & editing, Visualization, Supervision, Project Administration. Dongxiu Wu: Conceptualization, Validation, Formal analysis, Resources, Writing - original draft, Funding acquisition.