bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interphase Regulation by Multifunctional Additive Empowering High Energy Lithium‐Ion Batteries with Enhanced Cycle Life and Thermal Safety
Authors: Zhuang Xiangchun , Zhang Shenghang , Cui Zili , Xie Bin , Gong Tianyu , Zhang Xiaohu , Li Jiedong , Wu Rongxian , Wang Shitao , Qiao Lixin , Liu Tao , Dong Shanmu , Xu Gaojie , Huang Lang , Cui Guanglei 
Published: December 2023

AbstractHigh energy density lithium‐ion batteries (LIBs) adopting high‐nickel layered oxide cathodes and silicon‐based composite anodes always suffer from unsatisfied cycle life and poor safety performance, especially at elevated temperatures. Electrode /electrolyte interphase regulation by functional additives is one of the most economic and efficacious strategies to overcome this shortcoming. Herein, cyano‐groups (−CN) are introduced into lithium fluorinated phosphate to synthesize a novel multifunctional additive of lithium tetrafluoro (1,2‐dihydroxyethane‐1,1,2,2‐tetracarbonitrile) phosphate (LiTFTCP), which endows high nickel LiNi0.8Co0.1Mn0.1O2/SiOx‐graphite composite full cell with an ultrahigh cycle life and superior safety characteristics, by adding only 0.5 wt % LiTFTCP into a LiPF6‐carbonate baseline electrolyte. It is revealed that LiTFTCP additive effectively suppresses the HF generation and facilitates the formation of a robust and heat‐resistant cyano‐enriched CEI layer as well as a stable LiF‐enriched SEI layer. The favorable SEI/CEI layers greatly lessen the electrode degradation, electrolyte consumption, thermal‐induced gassing and total heat‐releasing. This work illuminates the importance of additive molecular engineering and interphase regulation in simultaneously promoting the cycling and thermal safety of LIBs with high‐nickel NCMxyz cathode and silicon‐based composite anode.
Volatile Perovskite Precursor Ink Enables Window Printing of Phase‐Pure FAPbI3 Perovskite Solar Cells and Modules in Ambient Atmosphere
Authors: Yuan Linhao , Chen Xining , Guo Xianming , Huang Shihao , Wu Xiaoxiao , Shen Yunxiu , Gu Hao , Chen Yujin , Zeng Guixiang , Egelhaaf Hans‐Joachim , Brabec Christoph J. , Yang Fu , Li Yaowen , Li Yongfang 
Published: December 2023

AbstractDespite the great success of perovskite photovoltaics in terms of device efficiency and stability using laboratory‐scale spin‐coating methods, the demand for high‐throughput and cost‐effective solutions remains unresolved and rarely reported because of the complicated nature of perovskite crystallization. In this work, we propose a stable precursor ink design strategy to control the solvent volatilization and perovskite crystallization to enable the wide speed window printing (0.3 to 18.0 m/min) of phase‐pure FAPbI3 perovskite solar cells (pero‐SCs) in ambient atmosphere. The FAPbI3 perovskite precursor ink uses volatile acetonitrile (ACN) as the main solvent with DMF and DMSO as coordination additives is beneficial to improve the ink stability, inhibit the coffee rings, and the complicated intermediate FAPbI3 phases, delivering high‐quality pin‐hole free and phase‐pure FAPbI3 perovskite films with large‐scale uniformity. Ultimately, small‐area FAPbI3 pero‐SCs (0.062 cm2) and large‐area modules (15.64 cm2) achieved remarkable efficiencies of 24.32 % and 21.90 %, respectively, whereas the PCE of the devices can be maintained at 23.76 % when the printing speed increases to 18.0 m/min. Specifically, the unencapsulated device exhibits superior operational stability with T90>1350 h. This work represents a step towards the scalable, cost‐effective manufacturing of perovskite photovoltaics with both high performance and high throughput.
Deconstructive Carboxylation of Activated Alkenes with Carbon Dioxide
Authors: Yuan Pan‐Feng , Yang Zhao , Zhang Shan‐Shan , Zhu Can‐Ming , Yang Xiu‐Long , Meng Qing‐Yuan 
Published: December 2023

AbstractCarboxylation with carbon dioxide (CO2) represents one notable methodology to produce carboxylic acids. In contrast to carbon–heteroatom bonds, carbon–carbon bond cleavage for carboxylation with CO2 is far more challenging due to their inherent and less favorable orbital directionality for interacting with transition metals. Here we report a photocatalytic protocol for the deconstructive carboxylation of alkenes with CO2 to generate carboxylic acids in the absence of transition metals. It is emphasized that our protocol provides carboxylic acids with obviously unchanged carbon numbers when terminal alkenes were used. To show the power of this strategy, a variety of pharmaceutically relevant applications including the modular synthesis of propionate nonsteroidal anti‐inflammatory drugs and the late‐stage carboxylation of bioactive molecule derivatives are demonstrated.
Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block β‐amyloid aggregation
Authors: Khudina Olga G. , Grishchenko Maria V. , Makhaeva Galina F. , Kovaleva Nadezhda V. , Boltneva Natalia P. , Rudakova Elena V. , Lushchekina Sofya V. , Shchegolkov Evgeny V. , Borisevich Sophia S. , Burgart Yanina V. , Saloutin Victor I. , Charushin Valery N. 
Published: December 2023

AbstractNew amiridine‐thiouracil conjugates with different substituents in the pyrimidine fragment (R = CH3, CF2Н, CF3, (CF2)2H) and different spacer lengths (n = 1–3) were synthesized. The conjugates rather weakly inhibit acetylcholinesterase (AChE) and exhibit high inhibitory activity (IC50 up to 0.752 ± 0.021 µM) and selectivity to butyrylcholinesterase (BChE), which increases with spacer elongation; the lead compounds are 11c, 12c, and 13c. The conjugates are mixed‐type reversible inhibitors of both cholinesterases and practically do not inhibit the structurally related off‐target enzyme carboxylesterase. The results of molecular docking to AChE and BChE are consistent with the experiment on enzyme inhibition and explain the structure–activity relationships, including the rather low anti‐AChE activity and the high anti‐BChE activity of long‐chain conjugates. The lead compounds displace propidium from the AChE peripheral anion site (PAS) at the level of the reference compound donepezil, which agrees with the mixed‐type mechanism of AChE inhibition and the main mode of binding of conjugates in the active site of AChE due to the interaction of the pyrimidine moiety with the PAS. This indicates the ability of the studied conjugates to block AChE‐induced aggregation of β‐amyloid, thereby exerting a disease‐modifying effect. According to computer calculations, all synthesized conjugates have an ADME profile acceptable for drugs.
Covalent Organic Framework‐derived Composite Membranes for Water Treatment
Authors: Elmerhi Nada , Kumar Sushil , Abi Jaoude Maguy , Shetty Dinesh 
Published: December 2023

AbstractWater treatment has experienced a surge in the adoption of membrane separation technology. Covalent organic frameworks (COFs), a class of metal‐free and open‐framework materials, have emerged as potential membrane materials owing to their interconnected periodic porosity, tunability, and chemical stability. However, the challenges associated with processing COF powders into self‐standing membranes have spurred the emergence of COF composite membranes. This review article highlights the rationale behind developing COF composite membranes and their categories, including mixed matrix membranes (MMMs) and thin film composite (TFC) membranes. The common fabrication techniques of each category are presented. In addition, the influence of COF additives on the performance of the resultant composite membranes is systematically discussed, with a focus on the recent progress in applying COF composite membranes in the separation of different categories of water pollutants, including organic ions/molecules, toxic solvents, proteins, toxic heavy metals, and radionuclides.
Two‐dimensional liquid chromatography measurement of meropenem concentration in synovial fluid of patients with periprosthetic joint infection
Authors: Jia‐Wei He , Jing Wang , Li Cao , Xiao‐Gang Zhang , Guo‐Qing Li , Bo‐Yong Xu , Bao‐Chao Ji , Jun‐jie Huang , Jun Zhao 
Published: December 2023

AbstractPeriprosthetic joint infection (PJI) is a catastrophic complication following joint replacement surgery. One potential treatment approach for PJI could be the combination of one‐stage revision and intra‐articular infusion of antibiotics. Meropenem is one of the commonly used intra‐articular antibiotics in our institution. Determining the concentration of meropenem in the joint cavity could be crucial for optimizing its local application, effectively eradicating biofilm infection, and improving PJI treatment outcomes. In this study, we developed a simple, precise, and accurate method of two‐dimensional liquid chromatography (2D‐LC) for determining the concentration of meropenem in human synovial fluid. The method was then validated based on the guidelines of the Food and Drug Administration and the Chinese Pharmacopoeia. Meropenem showed good linearity in the range of 0.31–25.01 μg/mL (r ≥ .999). Selectivity, intra‐day and inter‐day precision and accuracy, extraction recovery, and stability validation results were all within the acceptance range. This method has been successfully applied to the determination of synovial fluid samples from PJI patients, providing a useful detection method for meropenem therapeutic drug monitoring (TDM) in PJI patients.
The antianxiety effects of koumine and gelsemine, two main active components in the traditional Chinese herbal medicine Gelsemium: A comprehensive review
Authors: Long Jiangyu , Tang Mohuan , Zuo Mengting , Xu Wenbo , Meng Siyu , Liu Zhaoying 
Published: December 2023

AbstractThe genus Gelsemium belongs to the family Loganiaceae, one of the traditional Chinese herbs. Gelsemium is traditionally used to treat rheumatoid and neuropathic pain. Its root extracts were found to protect against anxiety, especially the alkaloids koumine and gelsemine. Indeed, koumine and gelsemine can act as positive agonists of the glycine receptor (GlyR), which reduces neuronal excitability through chloride influx and can also increase neuroactive steroid content by enhancing 3alpha‐hydroxysteroid oxidoreductase (3α‐HSOR) expression. The latter can activate the excitation‐inhibitory response via the γ‐aminobutyric acid type A receptor (GABAAR), reduce the abnormal corticotropin‐releasing hormone (CRH) increase in the hypothalamus, inhibit adrenocorticotropic hormone (ACTH) secretion, and effectively inhibit the abnormal ACTH and corticosterone increases in the circulation. In addition, koumine and gelsemine inhibited the expression of the NLR family pyrin domain containing 3 (NLRP3) inflammasome, inhibiting the release of inflammatory factors and regulating anxiety‐related neural circuits. Gelsemine also inhibited the overexpression of brain‐derived neurotrophic factor (BDNF) and cAMP response element‐binding protein (CREB) in the hypothalamus to maintain the plasticity of brain neurons and protect neurogenesis to achieve anxiety regulation. In general, this article reviews the recent studies on Gelsemium in the anxiety field, discusses its possible antianxiety mechanism, and confirms the potential of Gelsemium as a therapeutic drug for anxiety‐related diseases.
Advances in the treatment of IgA nephropathy with biological agents
Authors: Zhuang Yongze , Lu Hailing , Li Junxia 
Published: December 2023

AbstractImmunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease, and the “four‐hit” theory represents its currently accepted pathogenic mechanism. Mucosal immunity triggered by infections in the respiratory tract, intestines, or other areas leads to antigen presentation, T cell stimulation, B cell maturation, and the production of IgA‐producing plasma cells. The proteins B‐lymphocyte stimulator (BLyS) and a proliferation‐inducing ligand (APRIL) are involved in this process, and alternative complement and lectin pathway activation are also part of the pathogenic mechanism. Kidney Disease Improving Global Outcomes guidelines indicate that a specific effective treatment for IgAN is lacking, with renin–angiotensin–aldosterone system inhibitors being the primary therapy. Recent research shows that biological agents can significantly reduce proteinuria, stabilize the estimated glomerular filtration rate, and reverse some pathological changes, such as endocapillary proliferation and crescent formation. There are four main categories of biological agents used to treat IgA nephropathy, specifically anti‐CD20 monoclonal antibodies, anti‐BLyS or APRIL monoclonal antibodies, monoclonal antibodies targeting both BLyS and APRIL (telitacicept and atacicept), and monoclonal antibodies inhibiting complement system activation (narsoplimab and eculizumab). However, further research on the dosages, treatment duration, long‐term efficacy, and safety of these biological agents is required.
Tau and neurodegeneration
Authors: Goedert Michel , Crowther R. Anthony , Scheres Sjors H. W. , Spillantini Maria Grazia 
Published: December 2023

AbstractFirst identified in 1975, tau was implicated in Alzheimer's disease 10 years later. Filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. In 1998, mutations in MAPT, the gene that encodes tau, were identified as the cause of a dominantly inherited form of frontotemporal dementia with abundant filamentous tau inclusions. While this result indicated that assembly of tau into aberrant filaments is sufficient to drive neurodegeneration and dementia, most cases of tauopathy are sporadic. More recent work in experimental systems showed that filamentous assemblies of tau may first form in one brain area, and then spread to others in a prion‐like fashion. Beginning in 2017, work on human brains using high‐resolution techniques has led to a structure‐based classification of tauopathies, which has opened the door to a better understanding of the significance of tau filament formation.
Population‐Based Characterization of the Pharmacokinetics and Food Effect of ANAVEX3‐71, a Novel Sigma‐1 Receptor and Allosteric M1 Muscarinic Receptor Agonist in Development for Treatment of Frontotemporal Dementia, Schizophrenia, and Alzheimer Disease
Authors: Fadiran Emmanuel O. , Hammond Edward , Tran James , Missling Christopher U. , Ette Ene 
Published: December 2023

AbstractPharmacokinetic (PK) data from 28 subjects who received 5‐200‐mg single ascending doses of ANAVEX3‐71, formerly AF710B, were analyzed to characterize the PK of ANAVEX3‐71 and its M8 metabolite. PK data from 12 subjects who received 160 mg ANAVEX3‐71 under fed and fasted conditions were analyzed to characterize the effect of food on the PK of the drug and its M8 metabolite. PK was characterized using the standard 2‐stage approach and the nonlinear mixed‐effects modeling approach. Dose proportionality was determined using the power model. Two‐ and 3‐compartment linear PK models were tested for the characterization of the PK of ANAVEX3‐71 and its M8 metabolite. The PK of ANAVEX3‐71 is linear, dose proportional, and time invariant. The drug is rapidly eliminated with a mean (standard deviation) apparent terminal elimination half‐life of 3.56 (4.09) hours, while the M8 metabolite was eliminated with a mean (standard deviation) apparent terminal elimination half‐life of 6.59 (1.64) hours. The population PK model was used to investigate the effects of covariates on the PK of ANAVEX3‐71 and M8. Age, weight, and creatinine clearance were not explanatory of the variability in apparent clearance and apparent volume of the central compartment of ANAVEX3‐71. Food had no effect on the PK of ANAVEX3‐71 and its M8 metabolite.
Adolescent morphine exposure changes the endogenous vlPAG opioid response to inflammatory pain in rats
Authors: Alami Kawsar , Ghasemi Elmira , Semnanian Saeed , Azizi Hossein 
Published: December 2023

AbstractAdolescence is one of the most critical periods for brain development, and exposure to morphine during this period can have long‐life effects on pain‐related behaviors. The opioid system in the periaqueductal gray (PAG) is highly vulnerable to drug exposure. However, the impact of adolescent morphine exposure (AME) on the endogenous opioid system in the PAG is currently unknown. This study aims to investigate the long‐lasting effects of AME on the endogenous opioid system and its involvement in altering nociceptive behaviors. Adolescent rats were given escalating doses of morphine (2.5–25 mg/kg, subcutaneous) or an equal volume of saline twice daily for 10 consecutive days (PND 31–40). After a 30‐day washout period, adult rats underwent formalin tests following microinjection of morphine, naloxone, or saline into the ventrolateral PAG (vlPAG) region. The results indicated that morphine microinjection into the vlPAG of the adolescent morphine‐treated group significantly reduced the nociceptive score. However, the analgesic response to morphine in this group was significantly lower compared to the saline‐treated group during adolescence. Additionally, the nociceptive score significantly increased following naloxone but not saline microinjection into the vlPAG of the saline‐treated group during adolescence, rather than the morphine‐treated one. These findings indicate that AME has long‐lasting effects on the endogenous opioid system in the vlPAG, which can consequently alter behaviors related to inflammatory pain in adulthood.
Gravity‐driven flow control in a fully integrated microfluidic cartridge for molecular point‐of‐care testing
Authors: Zai Yunfeng , Wang Zunliang , Ding Yongjun , Min Chao , Liu Yuan , Zhao Huan , Su Enben , He Nongyue 
Published: December 2023

AbstractMolecular point‐of‐care testing (POCT) system is crucial for the timely prevention and control of infectious diseases. We recently proposed a gravity‐driven microfluidic cartridge for molecular POCT detection, without the need for external sources or actuators, demonstrating the advantages in terms of the reduced cartridge size and low development costs. How to achieve precise control of liquid flow behavior is challenging for the gravity‐driven cartridge. In this work, we explored the underlying mechanism of flow control in the cartridge and offered optimized solutions for our cartridge design to achieve precise control of dynamic flow rates and enhance pumping efficiency significantly. Through the computational fluid dynamics simulations, we demonstrated that adopting an asymptotic contraction chamber geometry design and a closed‐loop air flow channel design with the cartridge inlet can facilitate stable laminar flow of the liquid in our microfluidic cartridge, enabling precise control of flow velocity. We further optimized the microchannel diameter and the contact angle of the liquid with the microchannel wall. The effectiveness of the optimized cartridge for POCT detection was well validated by the accurate detection of the human papillomavirus type 16 virus in the 120 clinical swab samples.
Carbon Pricing is not Unjust
Authors: Mintz‐Woo Kian 
Published: December 2023

AbstractThe aim of this perspective is to argue that carbon pricing is not unjust. Two important dimensions of justice are distributive and procedural (sometimes called “participatory”) justice. In terms of distributive justice, it is argued that carbon pricing can be made distributionally just through revenue recycling and that it should be expected that even neutral reductions in emissions will generate progressive benefits, both internationally and regionally. In terms of procedural justice, it is argued that carbon pricing is in principle compatible with any procedure; however, there is also a particular morally justifiable procedure, the Citizens’ Assembly, which has been implemented in Ireland on this precise question and has generated broad agreement on carbon pricing. It is suggested that this morally matters because such groups are like “ideal advisors” that offer morally important advice. Finally, an independent objection is offered to some ambitious alternatives to carbon pricing like Green New Deal‐type frameworks, frameworks that aim to simultaneously tackle multiple social challenges. The objection is that these will take too long to work in a climate context, both to develop and to iterate.
Towards inclusive transport: The responsiveness of intercity bus services to the needs of people with disabilities in Tamale, Ghana
Authors: Akaateba Millicent Awialie , Adumpo Emile Akangoa , Yakubu Ibrahim 
Published: December 2023

AbstractPeople with disabilities (PWDs) have an equal right to independent mobility and dignified involvement in society, which is intrinsically related to their access to inclusive public transit systems. Yet, very often PWDs face injustices of unequal mobilities emanating from a combination of access barriers. Based on qualitative interviews and Focus Group Discussions with PWDs and station managers, this exploratory study assessed the responsiveness of public intercity bus services to the needs of PWDs with vision, hearing and walking/climbing difficulties. The findings show that, despite the Persons with Disabilities Act's passage in 2006, intercity public bus transportation services in Tamale, Ghana, do not meet the needs of PWDs. Intercity bus stations and vehicles are not disability‐friendly, leading to people with disabilities facing severe discrimination and having a more difficult time using intercity bus services. This is due to a combination of environmental barriers, legislative/policy inadequacies, negative public attitudes and low compliance of transport operators to transport provisions in the Disability Act. PWDs express deep‐seated feelings of marginalisation and resentment about the uneven access to transport services and the violation of their rights to autonomy in movement. It is concluded that the journey experiences of PWDs have a significant adverse influence on their travel decisions and full participation in society. Hence, suggestions for further research and policy recommendations to promote inclusive transport systems have been proffered.