bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anomalous Right Coronary Artery Managed with Bypass and Proximal Ligation
Authors: Ramcharran Harry , Nazem Ahmad 
Published: November 2023

Abstract
Background:
An anomalous origin and inter-arterial course of the right coronary artery is a rare anomaly that can lead to sudden ischemic cardiac death if left untreated. We present a case of a patient with an anomalous right coronary artery originating from the left coronary cusp and an inter-arterial course that was managed with coronary artery bypass surgery using a right internal mammary artery conduit. The proximal right coronary artery was ligated to prevent competitive flow.
Case Presentation:
A 69 year-old-male with a ten-year history of intermittent chest pain and dyspnea with a negative workup underwent a cardiac catheterization, which showed an anomalous right coronary artery (RCA) originating from the left coronary cusp, with an inter-arterial course between the ascending aorta and pulmonary artery, and greater than 70% narrowing of the proximal RCA. The patient underwent coronary artery bypass grafting via a median sternotomy and was cannulated for hypothermic cardiopulmonary bypass. The right internal mammary artery (RIMA) was skeletonized and used as a conduit, with the distal RCA being the target. A silastic band was placed around the proximal RCA, and a 2.0mm coronary flow probe (Transonic, Ithaca, NY, USA) was used to measure flow via the conduit with the proximal RCA occluded and un-occluded. With the proximal RCA occluded, peak flow via the conduit was greater due to the elimination of any competitive flow. The proximal RCA was ligated with a 2 − 0 silk suture and three metal clips. Intra-operatively, there were no signs of ischemia or arrhythmia. The patient was successfully taken off cardiopulmonary bypass. Post-operatively, he did well and was discharged on postoperative day 4.
Conclusions:
Symptomatic anomalous origin of the right coronary artery with an inter-arterial course can be treated successfully with coronary artery bypass surgery with the internal mammary artery as a conduit. Ligation of the proximal right coronary artery can minimize competitive flow through the bypass graft.
Note on Occurrence of Areca White Grub (Coleoptera, Scarabaeidae, Melolonthinae, Leucopholini) from Northern Western Ghats and its Implications
Authors: Jagdale Pranil , Magdum Sujata , Kalawate Aparna , Lole Kavita , Ramdasi Ashwini 
Published: November 2023

Abstract
Species of the genus Leucopholis are agricultural pests with an enigmatic taxonomic position and inadequate information on its diversity and ecology, particularly in the oriental region. We report the first ever distribution record of an Areca white grub, Leucopholis burmeisteri Brenske, 1894 from the Northern Western Ghats, Maharashtra, India. It is an economically important pest reported to be damaging the cash crops viz., sugarcane, coconut, Areca nut and several other vegetables. In this study the species was re-described with illustration of female specimens. The identity of the species was reconfirmed using DNA barcoding by sequencing the 5’ region of mitochondrial cytochrome oxidase subunit I (mtCOI-5P). The evolutionary history inferred by constructing a phylogenetic tree using Maximum Likelihood method based on the General Time Reversible model showed that L. burmeisteri formed clustered with L. burmeisteri reported from Karnataka thus reconfirming, by molecular means, the evolutionary affinity of the species with other species complex. The threats for the host plants are also discussed. Collection locality map and the images to facilitate the identification are also provided.
Identification of potent allosteric inhibitors of PRMT3: pharmacophore based 3D-QSAR modeling and molecular simulations approach
Authors: Mubarak Shoufia Jabeen , Vedagiri Hemamalini 
Published: November 2023

Abstract
Protein arginine methyltransferases are a family of proteins that play an important role in the regulation of gene expression, mainly involved in epigenetic modifications like DNA methylation and histone acetylation. Protein arginine methyltransferase 3 (PRMT) is a member of the PRMT family of enzymes involved in various cellular processes, including transcriptional regulation, RNA processing, and signal transduction. PRMT3 levels are considerably enhanced in certain types of cancers particularly breast, colorectal, lung and ovarian cancers. Studies have indicated that PRMT3 promotes tumor growth by activating oncogenes and suppressing tumor suppressor genes. PRMT3 is a histone-modifying enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine (SAM) to specific arginine residues in target proteins, thereby modulating their function. However, the activity of PRMT3 is not only regulated by its catalytic domain but also by allosteric mechanisms that control its enzymatic activity. Furthermore, targeting PRMT3 could potentially serve as a therapeutic strategy for treating various types of cancer. This study focuses on targeting the allosteric regulation of PRMT3 by exploring diverse compound libraries to identify potential inhibitors that would modify its cellular function. This computational approach involves the generation of pharmacophore hypothesis with 3D-QSAR validation, followed by virtual screening, docking and dynamic simulations to identify potent bioactive compounds as PRMT3 inhibitors. Virtual screening of natural products and PRMT specific libraries revealed the top lead molecules as cladribine, capecitabine, gefitinib, D175-0195, F602-1150 and F1361-0042. However, further validation studies are warranted to confirm these findings.
Effects of Different Forced-air Warming systems on the Core Temperature of Patients: A Manikin and Multi-center Clinical Study
Authors: Yang Heng , Hu Jicheng , Luo Hong , Wang Hao , Wang Xin , Zhang Chaofeng , Wang Yanjun , Yang Chai , Hu Xiaoxuan , Chai Xiaoqing 
Published: November 2023

Abstract
Purpose: The purpose of this study was to investigate the thermal protective function and running properties of different forced-air warming (FAW) systems in manikin and clinical study.
Methods:
Manikin study: Details of methods are provided in the following article.
Clinical study: Patients were randomly divided into four groups (Group A; Group B; Group C and Group D), with 30 cases in each group. At the beginning of anesthesia induction, the FAW blanket was turned on and adjusted to 43°C until the end of the operation. The primary outcome was the mean core body temperature in each group during the intraoperative period. Secondary outcomes included the incidence of perioperative surgical-related variables.
Results:
Manikin study: The detailed results are shown in the following article.
Clinical study: Though the mean perioperative core body temperature was all higher than 36°C in different groups (group A: 36.31±0.04; group B: 36.26±0.06; group C: 36.17±0.03; group D: 36.25±0.05), the core body temperature of patients in group A was higher than the other three groups (P<0.001). The incidence of perioperative hypothermia was lowest in group A, but the difference between the four groups was not statistically significant (group A:4 (13%); group B:7 (23%); group C:11 (37%); group D:7 (23%), P=0.212).
Conclusion: For patients undergoing laparoscopic radical resection of colorectal cancer under general anesthesia, four types of FAW systems can effectively prevent the occurrence of perioperative hypothermia, but group A warming system reduced heat loss to a greater extent than other blankets and achieved a better warming effect.
Trial registration: ChiCTR2200065394. (Data of Registration: November 3rd, 2022)
Real Life Event-Based Outcomes of Patients With Gaucher Disease Receiving ERT
Authors: Kılıç Ayşe , Inci Aslı , Okur Ilyas , Tümer Leyla , Ezgü Fatih Süheyl 
Published: November 2023

Abstract
Purpose
Gaucher Disease (GD) is a lysosomal storage disease. Mutations in GBA1 gene cause glucocerebrosidase enzyme deficiency that leads accumulation of its substrates. Clinical presentations of GD are cytopenia, hepatosplenomegaly, bone involvement and neurological impairment. Besides; abdominal pain, painful bone crises, bleeding, growth retardation, delayed puberty, pulmonary involvement, fatigue are other manifestations. This study has revealed event-based outcomes in GD patients undergoing ERT to evaluate real-life data to assess the impact of ERT on GD patients' lives.
Methods
The events consist of hematopoietic system related events, musculoskeletal system related events, gastrointestinal system related events, growth and puberty related events, respiratory system related events, neurological system related, routine daily activities related events and tumoral formation. Events were collected starting from 1 year before and up to 3 years form initiation of ERT and all events were collected every 6 months periods.
Results
Total of 31 events were reported between − 12 to -6 months and 17 events from − 6 months to baseline in all patients. After the initiation of ERT, the number of events decreased to 10 in 6–12 months. At the end of the follow-up period, between 30–36 months, only 1 event was recorded, the minimum event number overall. For all groups, there was a trend to decrease or stabilization of the events.
Conclusion
In conclusion, this is the first study that evaluate event-based outcomes in GD patients receiving ERT and show the real-life data by evaluating not only laboratory parameters but also clinical consequences of the treatment, providing practical clinical follow up.
A Controlled Study on the Application of Modified Internet-based Peyton Teaching Method in Clinical Skills Training
Authors: CHEN CHUANHUANG , Hu Zhi-Li , Chen Tan-Peng , Wu Wen-Shen , Chen Zhi-Qing , Chen Zhi-Hui , Xie Pei-Jun , Kuang Yi-Hua , Wang Zi-Mei 
Published: November 2023

Abstract
Objective
To compare the effects of the modified Internet-based Peyton teaching method and the traditional teaching method on clinical skills training.
Methods
Fourth-year medical students at Shenzhen University were randomly divided into two groups, the intervention group and the control group. The intervention group were trained using the modified internet-based Peyton method while the control group were trained in a traditional way. Their learning outcomes were assessed through student questionnaires and their final OSCE scores.
Results
Four items on the questionnaires showed staistical significance (P < 0.05) between the two groups, namely "I think the course helped me learn skills", "The course achieved my expected results", "I accept the format of the course", and "I think the class time is sufficient". The final OSCE results also showed statistical difference (P < 0.05) between the groups.
Conclusion
The application of the modified internet-based Peyton teaching method in clinical skills training can promote students' learning interest, stimulate their initiative for active learning, reduce their brain load to understand the in-class information, and increase the cooperation and mutual evaluation among students. It enriches the traditional teaching content and teaching modes, improving the students’ learning efficiency and skills retention.Therefore, the method is a beneficial tool for basic clinical skills training in the new era.
Development of Microwave Kinetic Inductance Detectors for a THz On-Chip Spectrometer
Authors: Brooks Elyssa , Barry Peter , Nie Rong , Shirokoff Erik , Filippini Jeffrey , Connors Jake , Gradziel Marcin , Mercado Dale , Spencer Locke , Tramm Serena , Trappe Neal , Zemcov Michael 
Published: November 2023

Abstract
Far-infrared (FIR) wavelength light provides a wealth of information about astrophysical processes. Large field-of-view FIR spectrometers face a variety of challenges that can be bypassed by utilizing on-chip filter bank technology. To this end, we have been developing microwave kinetic inductance detectors (MKIDs) to couple to on-chip spectrometric technologies. We utilize a unique two-silicon wafer design to create a waveguide for an on-chip spectrometer between 1.4 and 2 THz. The spectrometer's principle of operation is electromagnetic radiation traveling down a center waveguide before being picked off by a resonance cavity and absorbed by a detector. The MKIDs are designed to couple directly to the waveguide using an annular antenna shape for the inductor. Alignment of the two-wafer design is achieved with two dowel pins and a hole and slot pattern in our custom designed box. We present the design and early test data from a 18-channel prototype device. The prototype yielded the full 18 resonances with quality factors Qc of about 5 ∗ 104 and Qi of about 1 ∗ 104. We plan to use the technology we developed to create an n × n pixel device targeting R = 100.
The study of the relationships between diastasis recti abdominis and transversus abdominal: a scoping review
Authors: Luo Xiang , Leng Xiaohui , Li Zhenhong , Li Yuefeng , Ma Rui , Yang Kun 
Published: November 2023

Abstract
Background The main treatment for diastasis recti abdominis (DRA) is physical therapy. Most existing research focuses on the types of intervention to take, the effects of exercise, and the evaluation methods of these effects. So far, there are no recognized exercise programs. Perhaps researchers have overlooked the changes in trunk mechanics caused by pregnancy, as well as the relationship between biomechanics and exercises for DRA. This study aims to explore the mechanisms of rehabilitation exercise for DRA from a biomechanical perspective.
Methods PubMed, EMBASE, CNKI, and Web of Science databases were consulted using the terms 'Diastasis rectus abdominis, Abdominis Muscle,' 'Biomechanics,' 'Linea alba,' 'Physical therapy,' 'transversus abdominis,' and 'trunk stabilization.' All English and Chinese-written published articles were included until Oct, 2023.
Results The transverse abdominis muscle (TrA) is located deep within the abdominal wall and is attached to the fascia (aponeurosis) at both the front and back ends. During the Abdominal Drawing-In Maneuver, the muscles contract centrally. They shorten and thicken, resulting in reduced abdominal volume, increased abdominal pressure, and improved trunk stability. It also causes the displacement of the aponeurosis on both sides, resulting in centripetal force. The transverse fiber constitutes the main structure of the dorsal rectus sheath and the posterior layer of the linea alba. According to measurements obtained through shear wave elastic ultrasonic imaging and other equipment, the transverse stress is high and the compliance is low. Its biomechanical characteristics facilitate the transverse transfer of force generated by the TrA to the linea alba, and the force on both sides ends in the linae alba, which increases the tension. In patients with DRA, the linea alba undergoes significant deformation, and its stiffness decreases.
Conclusions The deformation of the linea alba is the main feature of DRA. TrA is the only muscle in the abdominal region that can increase the tension of the linea alba and improve the stability of the trunk by increasing internal abdominal pressure. Therefore, exercising TrA is the best treatment for the rehabilitation of DRA from mechanisms.
Clinical features and ALDH5A1 gene findings in 13 Chinese cases with succinic semialdehyde dehydrogenase deficiency
Authors: Dong Hui , Ma Xue , Chen Zhehui , Zhang Huiting , Song Jinqing , Jin Ying , Li Mengqiu , Lu Mei , He Ruxuan , Zhang Yao , Yang Yanling 
Published: November 2023

Abstract

Background and aims: To investigate the clinical features, ALDH5A1gene variations, treatment, and prognosis of patients with succinic semialdehyde dehydrogenase (SSADH) deficiency.
Materials and methods: This retrospective study evaluated the findings in 13 Chinese patients with SSADH deficiency admitted to the Pediatric Department of Peking University First Hospital from September 2013 to September 2023.
Results: 13 patients (seven male and six female patients; two sibling sisters) were diagnosed as SSADH deficiency aged from 4 months to 15 years. Their urine 4-hydroxybutyrate acid levels were elevated and were accompanied by mildly increased serum lactate levels. Brain MRI showed symmetric abnormal signals in both sides of the globus pallidus and other areas. All 13 patients had psychomotor retardation, with seven showing epileptic seizures. Among the 18 variants of the ALDH5A1 gene identified in these 13 patients, six were previously reported, while 12 were novel variants. Among 12 novel variants, three (c.85_116del, c.206_222dup, c.762C>G) were pathogenic variants; four (c.427delA, c.515G>A, c.755G>T, c.1274T>C) were likely pathogenic; and the remaining five (c.454G>C, c.479C>T, c.637C>T, c.1480G>A, c.1501G>C) were variants of uncertain significance (VUS). The patients received drugs such as L-carnitine, vigabatrin and taurine, along with symptomatic treatment. Their urine 4-hydroxybutyric acid levels showed variable degrees of reduction.
Conclusions: A cohort of 13 cases with early-onset SSADH deficiency were analyzed. Onset of symptoms occurred from 1 month to 1 year of age. 12 novel variants were identified from ALDH5A1 Gene.
Force Free Magnetic Field and Modifications in Kerr Black Hole
Authors: Sheikhahmadi Haidar 
Published: November 2023

Abstract
A recent research, presented a solution for a Schwarzschild black hole with a force-free magnetic field showing how the canonical form of background metric changes, [1]. Therefore, it is logical that this research seeks the modified solutions for the Kerr black hole as well. The goal of this paper is, thereby, to pinpoint an exact solution for the Kerr black holes perturbed by force-free magnetic fields. However, to do this we use a well known tetrad formalism and obtain an explicit expression for the electromagnetic strength tensor in the background metric, that is Kerr, based on the tangent space calculations. Analyzing the stress-energy tensor reveals the perturbed factors in the metric that allow us to understand better the physics of the disks around massive and supermassive black holes. These results show that it is not enough to depend solely on perturbation theory set against the background metric, without considering the backreaction of the force-free magnetufluid on it. This research indicates the necessity of studying the impact of force-free magnetic fields on the structure and evolution of mysterious cosmic objects.
Omics reveal the difference between PTDM and T2D among the liver, pancreas and adipose tissue
Authors: Liu Yuan , Wen Peizhen , Yang Yang , He Qining , Shi Wenjie , Xia Yan , Wang Haoyu , Tang Yangyang , Wang Rui , Zhang Tao , Fan Junwei , Peng Zhihai 
Published: November 2023

Abstract
Backgroud: This research delved into the underlying mechanisms responsible for post-transplant diabetes mellitus (PTDM) and comparisons with type 2 diabetes (T2D).
Methods: Comprehensive analyses, encompassing both transcriptomics and metabolomics, were conducted on liver and pancreatic tissues from the PTDM and T2D groups. Furthermore, distinctions in competing endogenous RNA (ceRNA) networks were explored. Weighted gene co-expression network analysis (WGCNA)was implemented to identify clusters of genes exhibiting strong correlations among the liver, pancreas, and adipose tissue.
Results: Compared to their T2D counterparts, PTDM mice exhibited notable differences in higher body weight (P <0.05), lower blood glucose levels (P <0.05), and enhanced insulin tolerance (P <0.05). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses indicated significant alterations in the MAPK pathway and leukocyte migration within the liver, as well as variations in the differentiation of Th17, Th1, and Th2 cells, along with T cell activation, within the pancreas. In addition, the MAPK signaling pathway and leukocyte migration pathways were significantly modified in adipose tissue. The ceRNA network analysis highlighted substantial changes, revealing 164 long intergenic non-coding RNA (lincRNA) and 154 circular RNA (circRNA) networks significantly changed in the liver, and 445 lincRNA and 135 circRNA networks in the pancreas that were significantly altered in the PTDM group compared to T2D group. Notably, the metabolites Resveratrol, Aldehydo-D-xylose, 3-Hydroxybutyric acid, 5-Aminoimidazole-4-carboxamide, Leucinic acid and (R)-lipoic acid displayed significant changes in the liver in PTDM mice, with their regulation attributed to 2510002D24RIK.
Conclusion:In summary, PTDM mice exhibited distinctive multi-omics and pathological characteristics compared to their T2D counterparts.
A Probabilistic Pluvial Flood Warning Model Based on Nest SOM Using Radar Reflectivity Data
Authors: Pan Tsung-Yi , Chen Lo-Yi , Hsieh Yi-Huan , Chen Buo-Fu , Lai Jihn-Sung 
Published: November 2023

Abstract

The occurrence and intensity of extreme weather events have increased under climate change, making flooding disasters more likely during the flood season from May to November in Taiwan. The current early warning system for flooding disasters developed by the Water Resources Agency in Taiwan relies on the density of rain gauges, which limits its effectiveness. To improve this system, our research collected historical radar reflectivity and rainfall data in the flood-prone area at the Zhonghua village of Taipei City. An unsupervised neural network called the self-organizing map (SOM) is applied to establish the relationship between radar reflectivity and rainfall observations, enabling the analysis of clustering vectors corresponding to pluvial flood disaster events. A Nest SOM-based pluvial flood warning model was proposed in identifying flooding hot zones and delivering probabilistic flood warning information. Based on radar reflectivity characteristics along with corresponding rainfall intensity and frequency, the proposed model was evaluated during extreme events to demonstrate its applicability and provide probabilistic warning information prior to flood disasters. Consequently, the model provides considerable practical value in enhancing flood disaster management.
Measurment of Natural Radioactivity and Evaluation of Radiation Hazards in Rock Samples of Seashore, Kanyakumari District
Authors: M suji , Shanthi G 
Published: November 2023

Abstract
The goal of the current research was to examine the radiation environment, along the most visited seashores in Tamil Nadu, India, Kanyakumari District. Gamma ray spectrometry was used to determine the average activity concentrations of radioactive elements such as 238U, 232Th, and 40K in seashore rock samples. Objective of this study is to quantify the amounts of natural radioactivity present in the chosen samples. Additionally, an evaluation of radiological risks posed by naturally occurring radionuclides was conducted, and the average activity-concentrations of 238U, 232Th, and 40K are 37.93, 187.51, and 461.95 (Bq/Kg) respectively. In this study, the yearly effective radiation dosage, air absorbed gamma radiation dose rate, and hazard index (Hin, Hex), alpha index, gamma index, representative level index value, activity utilization index, annual gonald dose equivalent were estimated. Results of this were little high recommended safe and criterion limit given by UNSCEAR. Statistical method was used to study the relation between radionuclides and also calculated radiation parameters. Result of this study revealed a selected seashore rock is high in emitting gamma radionuclides, but it doesn’t lead to significant health hazards to the exposed populace. The current findings provided as a crucial benchmark for any upcoming radiological research in Kanyakumari District, Tamil Nadu.