bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting the efficacy of drug therapy in patients with plaque psoriasis
Authors: Khokhlov A. L. , Samarina E. I. , Lileeva E. G. 
Published: February 2025

Relevance. The selection and modification of drug therapy for patients with plaque psoriasis does not have a specific solution for practicing specialists. Factors have been identified that can worsen the course of the disease when therapies with proven clinical efficacy are used and can even increase the severity and prevalence of the psoriatic process, leading to the development of erythroderma or resistance to the therapy. This article analyzed the actual clinical practice of plaque psoriasis therapy and the influence of concomitant diagnoses on the choice of therapy by physicians among patients who were treated in skin and venereal disease dispensaries in the Central Federal District from 2022 to 2023.Objective. To conduct a pharmacoepidemiological analysis of drug prescriptions and the volume of their consumption for plaque psoriasis using frequency analysis and analysis of average daily doses at the outpatient and inpatient stages of treatment, followed by a search for patterns.Materials and methods. An open, non-randomized, cross-sectional prospective study of outpatient records and hospital discharge summaries of 336 patients diagnosed with L40.0 plaque psoriasis was conducted over 2 years. Patients were surveyed by their physicians regarding their adherence to the physician recommendations using a questionnaire on adherence to therapy. The presence of complications of the primary diagnosis, concomitant diagnoses, and factors influencing the prescription of methotrexate and monoclonal antibodies were analyzed.Results. Patients prescribed methotrexate drugs had significantly more concomitant diseases (p <0.05). In addition to the primary diagnosis, patients treated with methotrexate had significantly less of the following: psoriatic arthritis, polyarthritis, spondyloarthritis, dactylitis, enthesitis, and psoriatic onychodystrophy compared with the group of patients who were prescribed genetically engineered biological drugs (p <0.05). The multivariate analysis revealed the influence of skin lesion severity and patient adherence on therapy choice.Conclusions. Among patients prescribed genetically engineered drugs, concomitant complications of an arthropathic nature were significantly more common — in 32.5 % of cases, versus 18.2 % in the group of patients on methotrexate (p <0.05). Therefore, the choice in favor of monoclonal antibodies in most cases was due to the presence of arthropathic psoriatic complications, skin lesion severity, younger age, and high adherence to the innovative therapy prescribed by the doctor (p <0.05).
Prevalence and severity of chronic kidney disease in a therapeutic hospital in patients with hypertension, angina pectoris, and type 2 diabetes mellitus: real practice of treating
Authors: Pegashova M. A. , Chizhov P. A. , Smirnova M. P. , Medvedeva T. V. , Кorkina M. I. 
Published: February 2025

Relevance. Chronic kidney disease (CKD) develops in the context of many diseases and has a progressive course, with the outcome of chronic renal failure.Objective. To study the prevalence and severity of CKD in patients of the therapeutic department with hypertension, coronary heart disease (CHD) by type of angina 2-3 FC (NYHA), type 2 diabetes mellitus (T2DM) and their combinations, as well as the real practice of therapy of such patients.Materials and methods. A total of 193 patients (average age 64.0 ± 18.1 with hypertension, CHD, T2DM, and their combinations were examined and treated in the therapeutic department of the N.A. Semashko City Hospital in the Yaroslavl Region was closed due to deterioration of their condition. The glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. Statistical processing of the results was performed using the Statistica 12.0 program (StatSoft. Inc., USA).Results. CKD stage 1 was diagnosed in 4.3% of the examined patients, stage 2 in 18.2%, stage 3 in 42.6%, and stage 4 in 2.9%. CKD stages 1 and 2 were significantly more common in patients with isolated hypertension, compared with those examined with hypertension + coronary heart disease + T2DM (p = 0.01, p = 0.03, respectively). CKD stage 3 was diagnosed in 100% of patients with T2DM + coronary heart disease. In patients with stage 3 hypertension and 3 FC CHF (NYHA), obesity, the GFR was significantly lower in men than in patients with stage 1 and 2 hypertension, with 2 FC CHF, no obesity, and women. Correlations of GFR with age and duration of hypertension and T2DM were established. The shortcomings of pharmacotherapy of patients with CKD in the hospital were revealed: no one receives IDPP-4 and gliflozins, some patients with low SCF receive metformin, some do not receive angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, statins, and some patients with type 2 diabetes did not undergo proper titration of the dose of hypoglycemic drugs.Conclusions. CKD stages 1–4 were detected in 68% of patients with hypertension, coronary heart disease, and/or type 2 diabetes in the therapeutic hospital, of which 42.6% had stage 3 and 2.9% had stage 4. The GFR value was associated with the degree of hypertension, FC CHF (NYHA), obesity, sex, age, hypertension duration, and type 2 diabetes. In hospitals, recommendations for pharmacotherapy for patients with CKD are not always followed.
Pathogenetic features of functional disorders in the remaining kidney during the early postoperative period of radical nephrectomy
Authors: Shormanov I. S. , Kosenko M. V. , Shchedrov D. N. , Zhigalov S. A. , Solovyov A. S. , Sokolova H. A. 
Published: February 2025

Relevance. Despite the widespread introduction of organ-preserving operations into urological practice, the number of radical nephrectomies has continued to increase. The results of modern research show that the initial stages of diseases of the remaining kidney are already formed at the earliest possible time after radical nephrectomy; therefore, adequate management of the postoperative period is a key factor in the prevention of diseases of the single kidney. However, this approach should be based on a detailed understanding of the mechanisms of adaptive restructuring of the body, which have a key effect on the morphology and function of a single kidney.Objective. To study the features of adaptive body reactions and the dynamics of the functional state of a single kidney following radical nephrectomy.Materials and methods. In the early postoperative period, the clinical and laboratory parameters of 85 patients who underwent radical nephrectomy for renal cell carcinoma in the T2-T3N0M0 stage were studied. The control group comprised 25 patients who underwent similar operations for the same indications within a period of 1.5–12 months. The metabolism of adrenaline, histamine, and serotonin, indicators of psychological and emotional states, vegetative-vascular status, and nitrogen excretion and filtration functions of the remaining kidney were studied.Results. Radical nephrectomy, as well as the period of conscious expectation, is the cause of a stress syndrome that occurs due to an imbalance of the studied biogenic amines, accompanied by disorders of psychological and emotional health and vegetative-vascular disorders observed at least during the 2 weeks of the postoperative period. In addition, the filtration capacity of a single kidney is impaired, and it persists for 14 days at follow-up. Correlation analysis made it possible to establish reliable links between the imbalance of biogenic amine and anxiety levels and the severity of autonomic vascular disorders, which adversely affect kidney filtration.Conclusions. The results of this study indicate the need for pharmacological subsidies during the postoperative period of radical nephrectomy, which makes it possible to offset the negative impact of stress syndrome on the outcome of surgical treatment.
Regional blockage as a component of reduced mammoplasty multimodal pain relief
Authors: Ganert A. N. , Lyuboshevskiy P. A. , Sokolov D. A. 
Published: February 2025

Relevance. Postoperative pain management remains poorly understood. Analgesics traditionally used to treat postoperative pain have numerous side effects. The optimal method for preventing postoperative pain is based on the principle of multimodality, where in addition to the use of analgesics with different application points, regional blockades are applied. In chest wall surgery, blockage of the thoracic nerves (PEC block) and the space of the muscles of the spine straightener (ESP block) under ultrasound control are gaining popularity.Objective. We compared the analgesic efficiency of PEC block and ESP block in multimodal analgesis without opioids during the postoperative period of reduction mammoplasty.Materials and methods. Sixty patients were examined with bilateral reduction mammography. Three groups were selected: PEC group of the block (n=20), ESP group of the block (n=20), and control group (n=20). The amount of fentanyl and inhalant anesthetic consumed, postoperative pain on Visual Analogue Scale (VAS), side effects of analgesics, and patient activation were evaluated.Results. Intraoperative fentanyl and inhalant consumption were significantly lower in the block PEC and block ESP groups than in the control group. The post-wake and 1and 3-hour postoperative pain syndrome rates were significantly lower in the block PEC and block ESP groups than in the control group.Conclusions. ESP-block and PEC-block are effective regional anesthesia methods that provide good intra- and postoperative analgesia. They also have a significant opioid-saving effect. They allow significantly earlier activation of patients. ESPblock slightly surpassed PEC block in duration, but other differences were not.
Clinical and practical use of domestic and imported articaine during difficult clinical situations during maxillofacial surgery in outpatient dentistry: case study
Authors: Put S. A. , Bessonov S. N. , Skukhtorov V. V. 
Published: February 2025

Relevance. The study aimed to compare the depth of anaesthesia, effectiveness, and hemostasis when using two articaine-based drugs: «Articaine-Binergia with epinephrine» 1:200000 and «Ubistesin forte» 1:100000, using a clinical case of the removal of tooth buds 38 and 48 in the lower jaw under conscious sedation in a patient with pronounced dental phobia. Articaine drugs, domestic «Articaine-Binergia with epinephrine» 1:200000 and imported «Ubistesin forte» 1:100000, are approved for use in the Russian Federation. The novelty of this study lies in the application of drugs from the same group of different manufacturers on the same patient under symmetrical clinical conditions by one specialist at the same level of trauma. No such studies were found in the literature.Objective. The aim of this study was to compare the effectiveness of domestic and imported analogues of local anaesthetics based on articaine in a single patient. The methodological objective is to assess the depth of anaesthesia, effectiveness, and hemostasis, as well as the patient’s subjective sensations and level of dental anxiety.Materials and methods. A review of the clinical case allows for the assessment of patients' subjective sensations during sedation with preserved consciousness against the background of taking sedative drugs and central analgesics using the «painno pain» scale. The level of dental anxiety was also determined using the Corah's Dental Anxiety Scale. Sedative drugs were used at doses that did not provide complete anaesthesia in the surgical intervention area, allowing the patient to clearly respond to pain stimuli during local, particularly conductive anaesthesia.Results. Under conditions of intravenous sedation with preserved consciousness, pain sensations are mitigated when local anaesthesia is ineffective, thereby reducing the patient’s psychological discomfort. The use of «Articaine-Binergia with epinephrine» 1:200000 and «Ubistesin forte» 1:100000 allowed for an objective comparison of their effectiveness and safety.Conclusions. Stable hemodynamic indicators on the monitors indicate high-quality anaesthesia and the absence of pain sensations; otherwise, the indicators on the monitor would have fluctuated. The data obtained confirm that both articaine-based drugs have similar effectiveness and provide an adequate level of anaesthesia in clinical intervention conditions, reducing the patient's anxiety and discomfort. One clinical case is not definitive; therefore, further research with a larger amount of statistical data is required.
Analysis of the registration and manufacturing of heparin drugs in Russia
Authors: Lavrentyeva L. I. , Zakharov A. V. 
Published: February 2025

Objective. To analyze the circulation processes of heparin group drugs for 2004–2024 from the point of view of the rates of registration and localization of production of active pharmaceutical substances (APS), finished dosage forms, and prospects for implementing a full production cycle in Russia.Materials and methods. An analysis of information from 693 registry entries in the State Register of Medicines dedicated to heparin-based drugs was conducted, and a database was compiled in Microsoft Excel. Information on registered drugs was classified according to their belonging to the heparin group, the name of the APS, dosage form, date of registration, presence in the list of vital and essential drugs, country of manufacture of the APS, and finished dosage forms.Results. In accordance with the anatomical-therapeutic-chemical classification, more than 20 names of drugs were classified as heparin group drugs: unfractionated heparin, low-molecular-weight heparin, heparinoid, and antithrombin III. 95 current registration certificates (hereinafter referred to as RC) and 13 RC excluded from the State Register of Medicines were studied — a total of 108 RC. Graphs were constructed to reflect the rate of drug registration in each named group. The highest rates of registration are observed in the period from 2020 to 2024 — on average 5.25 drugs are approved per year. The years with the most active registration were 2011 (11 approved drugs), 2017 (8 approved drugs), and 2023 (9 approved drugs). The production localization of heparin drugs for 2024 is presented in the diagrams. The main country producing APS for heparin drugs is China. However, for every fifth heparin drug, the full production cycle can be performed in Russia, including the synthesis of APS.Conclusions. Information was received on the structure of the product range (95 drugs are presented in 10 dosage forms for 5 different routes of administration), rate of registration of drugs in the heparin group, and localization of production of the APS, finished dosage form. The production of APS for sodium heparin is concentrated in China. Information is known about the construction in the coming years in Russia of three production sites for the production of the APS of sodium heparin: by the Chinese company “Hebei Changshan Biochemical Pharmaceutical”, the Russian company’s “Pharmasyntez-Kama” and “Severnyj ocean”. At present, only Russian companies are declared to be suppliers of APS is 3 drugs. Heparin drugs are mainly produced in Russia (75.4 % for sodium heparin drugs and 65.1 % for low-molecular-weight heparin).
Erythrocytic indices of clinical blood analysis and reference intervals among men and women aged 18–45 years
Authors: Rechkina O. P. , Adamov D. D. , Stribets T. B. , Lapkina N. A . , Baranov A. A. , Mineeva L. A. , Belyaeva N. V. , Malakhov N. V. 
Published: February 2025

Relevance. The determination of reference intervals (RI) in clinical blood analysis for erythrocytes and their specific parameters: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW), allows us to use these parameters for differential diagnostics of various pathological conditions from variants of norm.Objective. Calculate the RI for erythrocyte parameters of a complete blood count for patients in a certain age group (18– 45 years) with normal indicators of iron homeostasis. The reference ranges may vary depending on the analytical systems and diagnostic reagents used.Material and methods. The study included blood samples from 158 healthy volunteers aged 18–45 years, of whom 127 (80.4 %) were women and 31 (19.6 %) were men. The data were obtained from the «KDL-TEST» company database for the period from 01.01.2023 to 01.01.2024. The criteria for inclusion in the study were: age from 18 to 45 years, clinical blood test results, and iron homeostasis within the RI of the «KDL-TEST» laboratory, absence of signs of an inflammatory process based on normal levels of C-reactive protein (CRP). Analyses were performed using a hematological analyzer Mindray BC- 6800 (manufactured by Mindray, China) and an automatic biochemical analyzer model AU-5800 (Beckman Coulter, USA) using IRON reagents (Beckman Coulter, USA) for the photometric colorimetric method and CRP-latex (Beckman Coulter, USA) immunoturbidimetric method.Results. The studies revealed a decrease in the upper limit of the RI for red blood cells (RBC) and their indices (RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV) in women compared with the RI of the Russian National Standard (2009), which amounted to 4 % for the number of red blood cells, 5 % for hemoglobin, 2 % for hematocrit, 3.8 % for MCV and 3.5 % for MCH, as well as 4.2 % for MCHC; and a decrease in the upper limit of the RI of erythrocytes and erythrocyte indices (RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV) in relation to the RI of the Russian National Standard (2009) in men for erythrocytes by 3.9 %, hemoglobin by 4, 6 %, MCV — by 1.9 %, MCH — by 4 %, MCHC — by 5.8 %. No significant differences were found in the values of erythrocytes and their specific parameters, hemoglobin, and hematocrit, between the data of the hematology analyzers Mindray BC-6800 and Sysmex XE series (p >0.05).Conclusions. A decrease in the RI of clinical blood analysis in women and men for some hemogram parameters (RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV) in comparison with the RI of clinical blood analysis of the Russian National Standard (2009), which are within the generally accepted statistically acceptable deviations, was found. The use of automated hematology analyzers did not significantly affect the RI of erythrocytes or their specific parameters.
Analysis Of City Branding Strategies In Increasing Visitor Attraction (Case Study On Tourism History Of Marlborough Fort, Bungkarno House In Bengkulu Province)
Authors: Indriani Reni , Veronika Nora 
Published: February 2025

This research aims to analyze the city branding strategy used to increase visitor attraction in Bengkulu Province, with a focus on historical tourism objects such as Fort Marlborough, Bung Karno's House, and the British Cemetery. The research methodology employed was descriptive in nature, utilizing a qualitative approach. Data collection involved conducting interviews with relevant stakeholders and conducting direct observations on-site. Analysis was carried out on the city branding strategy applied to this historical tourism object and its impact on increasing the number of visitors. The research results show that the implementation of city branding in the historical destination of Bengkulu still needs more attention, especially in the aspects of image management, promotion and local community participation.
The Influence Of Time Budget Pressure And Locus Of Control On Audit Judgment Of The BPKP Aceh
Authors: Susanti Eva , Syawalina Cut Fitrika , Khaira Fathul 
Published: February 2025

The purpose of this research is to determine the influence of time budget pressure, internal locus of control and external locus of control on audit judgment. This research is quantitative research and uses a questionnaire which is distributed to respondents. The selection of respondents was based on a purposive sampling technique on 58 auditors at the Aceh Financial and Development Supervisory Agency (BPKP) Representative office. The data analysis method used in this research is multiple linear regression analysis. The research results show that Simultaneously the time budget pressure, internal locus of control and external locus of control abilities influence the audit judgment. Furthermore the results of partial hypothesis testing show that the time budget pressure has a positive abilities influence on audit judgment, internal locus of control has a negative abilities influence on audit judgment, external locus of control has a positive abilities influence on audit judgment.
Analisis Kriminologis Korupsi Perspektif Pendekatan Sobural Sebagai Upaya Pencegahan Korupsi di Indonesia
Authors: Hajairin Hajairin , Ma'arij Aman , Ilham Ilham , Gufran Gufran 
Published: February 2025

Korupsi merupakan fenomena kejahatan yang bersifat kompleks, tidak hanya berkaitan dengan persoalan hukum, melainkan juga persoalan sosial politik dan kebudayaan, sehingga pendekatan penyelesaianya juga dapat menggunakan pendekatan sosial, budaya dan structural. Kerumitan dalam pemberantasan korupsi selalu terjadi, hal ini terlihat semakin meningkatnya tindak pidana korupsi, baik dari segi kuantitas maupun jumlah kerugian negara yang diakibatkan oleh tindak pidana korupsi. Metode sobural bukanlah suatu prinsip yang digunakan untuk menyelesaikan suatu masalah atau kasus, namun metode ini berperan dalam memahami suatu perbuatan jahat secara tepat melalui tiga lensa nilai yang mempengaruhinya, yaitu nilai sosial, nilai kultural, dan unsur struktural. Tujuan penelitian ini untuk mengetahui Analsisi kriminologis korupsi prespektif teori sobural. Metode penelitian yang digunakan adalah Dalam penelitian ini menggunakan metode penelitian hukum normatif, yaitu penelitian yang difokuskan untuk mengkaji penerapan kaidah-kaidah atau norma-norma dalam kehidupan sosial masyarakat. Dengan pendekatan antara lain pertama Pendekatan Historis (Historical Aprroach) dilakukan untuk memahami nilai-nilai sejarah yang menjadi latar belakang pendekatan nilai sosial, nilai budaya dan faktor struktural (Sobural) menjadi pisau analisa kriminologis yang membedah causa kejahatan Korupsi. Kedua Pendekatan Konseptual (Conceptual Approach). Temuan berdasarkan hasil penelitian yakni pertama pendekatan nilai sosial, nilai budaya dan faktor struktural (Sobural) menjadi pisau analisa kriminologis yang membedah causa kejahatan secara utuh, baik diri pelaku maupun masyarakat. Keunggulan pendekatan nilai sosial, nilai budaya dan faktor struktural (Sobural) memberikan cara bagi penegak hukum, terutama hakim untuk memahami perbuatan korupsi dalam memutuskan perkara. Kedua pendekatan sobural dapat menjadi instrument kegiatan pencegahan korupsi, sebab pencegahan korupsi pada dasarnya merupakan bagian dari semangat pemberantasan korupsi. Untuk menghindari korupsi, sangat penting untuk memperhatikan pendekatan Sobural pada masyarakat di mana tindakan tersebut dilakukan dalam hal nilai sosial, budaya, dan variabel struktural sebagai upaya pencegahan korupsi.