bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sirt3 Regulates Proliferation and Progesterone Production in Leydig Cells via Suppression of Reactive Oxygen Species
Authors: Matoba Hisanori , Fujii Chifumi , Maruyama Kazuaki , Kawakubo Masatomo , Momose Masanobu , Sano Kenji , Imamura Hitomi , Kurihara Hiroki , Nakayama Jun 
Published: February 2024

AbstractSirt3 is a mitochondrial protein deacetylase functioning in energy metabolism, regulation of intracellular reactive oxygen species (ROS) levels, and aging. Although Sirt3 loss has negative effects on fertility of oocytes during in vitro fertilization and on progesterone production in granulosa cells, Sirt3's function in Leydig cells remains unclear. Therefore, we investigated Sirt3 activity in Leydig cells, focusing on androgen production. To do so, we performed immunohistochemistry to confirm Sirt3 localization in gonads and observed strong Sirt3 immunostaining in Leydig cells of human testes and of Sirt3+/+ and Sirt3+/− mouse testes, while Sirt3−/− mouse testis tissue was negative. In human ovary, hilus cells were strongly Sirt3-positive, theca cells showed weak positivity, and granulosa cells showed very weak or almost no immunostaining. Next, we used the murine Leydig tumor cell line MA-10 as a model. We overexpressed Sirt3 but observed no changes in proliferation, expression of Star, Cyp11a1 (p450scc gene), and Hsd3b, or progesterone production in MA-10 cells. Sirt3 knockdown significantly reduced proliferation, suppressed expressions of steroidogenic enzymes and of transcription factors Ad4bp (Sf-1 gene) and Gata4, and decreased progesterone production. Sirt3 knockdown in MA-10 cells also increased intracellular ROS levels based on CM-H2DCFDA fluorescence dye analysis and increased the proportion of both early and late apoptotic (necrotic) cells based on Annexin V/7AAD assays. These results indicate that Sirt3 has a potential function in androgen production in Leydig cells by regulating intracellular ROS levels.
Mother-Daughter Ventricular Endoscopy: A Technical Note and 2-Dimensional Video
Authors: Koueik Joyce , Sivan Vivek , Chebel Roy , Peek Michael , Iskandar Bermans J. 
Published: February 2024

BACKGROUND AND IMPORTANCE:
While navigating the ventricles with a rigid endoscope provides excellent visualization and the ability to use endoscopic instruments for complex surgery, these endoscopes are often too large to navigate tight areas. We present a surgical video showing the technique of mother-daughter endoscopy, which consists of the introduction of a flexible 1-mm fiberoptic endoscope through the channel of a large rigid endoscope to allow visualization across small spaces or channels, in this case, the cerebral aqueduct. This combination of superior visualization and handling of rigid endoscopes and flexibility and small size of fiberoptic endoscopes enhances safety and broadens possibilities in ventricular surgery.

CLINICAL PRESENTATION:
A 64-year-old woman with prior endoscopic aqueductoplasty for triventricular hydrocephalus and a failed endoscopic third ventriculostomy presented with focal restenosis of the aqueduct. A repeat endoscopic aqueductoplasty with stent placement were performed. Mother-daughter endoscopy was used to explore the occluded aqueduct for improved safety before fenestration and to ensure proper stent placement after fenestration.

CONCLUSION:
Mother-daughter endoscopy can add safety to complex or high-risk endoscopic procedures, particularly those with tight spaces that the large mother endoscope cannot visualize.
Hibernating female big brown bats (Eptesicus fuscus) adjust huddling and drinking behaviour, but not arousal frequency, in response to low humidity
Authors: Muise Kristina A. , Dzal Yvonne A. , Fletcher Quinn E. , Willis Craig K. R. 
Published: February 2024

ABSTRACT
Many mammals hibernate during winter, reducing energy expenditure via bouts of torpor. The majority of a hibernator's energy reserves are used to fuel brief, but costly, arousals from torpor. Although arousals likely serve multiple functions, an important one is to restore water stores depleted during torpor. Many hibernating bat species require high humidity, presumably to reduce torpid water loss, but big brown bats (Eptesicus fuscus) appear tolerant of a wide humidity range. We tested the hypothesis that hibernating female E. fuscus use behavioural flexibility during torpor and arousals to maintain water balance and reduce energy expenditure. We predicted: (1) E. fuscus hibernating in dry conditions would exhibit more compact huddles during torpor and drink more frequently than bats in high humidity conditions; and (2) the frequency and duration of torpor bouts and arousals, and thus total loss of body mass would not differ between bats in the two environments. We housed hibernating E. fuscus in temperature- and humidity-controlled incubators at 50% or 98% relative humidity (8°C, 110 days). Bats in the dry environment maintained a more compact huddle during torpor and drank more frequently during arousals. Bats in the two environments had a similar number of arousals, but arousal duration was shorter in the dry environment. However, total loss of body mass over hibernation did not differ between treatments, indicating that the two groups used similar amounts of energy. Our results suggest that behavioural flexibility allows hibernating E. fuscus to maintain water balance and reduce energy costs across a wide range of hibernation humidities.
The Frequency of Dedicated Coursework in Behavior Change in Accredited Baccalaureate Exercise Science Programs
Authors: Stapleton Drue T. , Kerner Lauren , Guers John J. 
Published: February 2024

ABSTRACT

Introduction/Purpose
Despite the well-established benefits of physical activity (PA), low levels of participation in PA remain a concern. Professional programmatic standards including behavior modification techniques are outlined by the Commission on Accreditation of Allied Health Education Programs (CAAHEP) and the Commission on the Accreditation of Exercise Science (CoAES), but it is not clear how these competencies are being met. Given the complexities of PA behavior, dedicated coursework addressing the fundamentals of behavior modification is valuable. The purpose of this study was to examine the prevalence of dedicated coursework focused on behavior change in CAAHEP/CoAES-accredited baccalaureate exercise science (EXS) programs.

Methods
We searched the curricula of CAAHEP/CoAES-accredited baccalaureate EXS programs to determine if dedicated behavior modification courses were required. We organized programs by American College of Sports Medicine region and Carnegie Classification.

Results
Of the 65 accredited programs found, 19 (29%) had specific courses in behavior modification. Of these 19 programs, New England (57%) and Northland (50%) regions had the highest percentage of required coursework. Carnegie master’s colleges and universities had the highest percentage of programs containing dedicated courses on behavior change (42%), compared with baccalaureate colleges (21%) and doctoral universities (37%).

Conclusions
Despite established educational competencies, many accredited EXS programs do not include dedicated coursework in behavior modification. Although CAAHEP/CoAES accreditation standards include behavior modification competencies, to maximize the benefits of PA and exercise and prepare the next generation of exercise professionals, dedicated coursework in behavior change should be incorporated into EXS curricula.
current possible treatment approaches of Polycystic Ovary Syndrome (PCOS)
Authors: Lipińska Justyna , Kowalczuk Maria , Lipiński Łukasz , Kopeć Izabela , Kamiński Jakub , Klimczak Klaudia , Loryś Laura , Narloch Marcin , Kasprzak Stanisław , Kasprzak Karolina 
Published: February 2024

Introduction
Polycystic ovary syndrome (PCOS), first described by Stein and Leventhal in 1935, is one of the most prevalent endocrine system conditions affecting women of reproductive age. It affects between 6% and 13% of women and the majority of cases are identified between the ages of 20 and 30. Unfortunately, the disease is usually diagnosed only when bothersome symptoms such as hair loss, alopecia, acne, and infertility-related problems occur. Based on the Rotterdam criteria, four phenotypes of PCOS are distinguished.
Aim of the study
This review aims to present the current state of knowledge about possible treatment approaches, both non-pharmacological and pharmacological.
Materials and methods
The paper was created based on the Pubmed database. The literature was reviewed using the keywords: ”PCOS”, ”PCOS treatment” and “ PCOS medications “.
The current state of knowledge
Treatments for PCOS must be tailored to the specific needs of each patient. In the management of PCOS, special attention is paid to diet, physical activity, and restoration of the Gut Microbiome. Medications used in therapy are oral contraceptives and anti-androgens, insulin sensitizers, ovulation inducers, calcium and vitamin D supplements, statins, Glucagon-like-peptide-1 (GLP-1) agonists, inositols and interleukin 22 (IL-22) therapy.
Summary
Treatment options for menstrual irregularities and hirsutism are based on the clinical goals and preferences of the patient. The ideal would be causal treatment, but due to the ongoing lack of full understanding of the pathogenesis of the syndrome, is not entirely feasible. The ideal would be causal treatment, but due to the ongoing lack of full understanding of the pathogenesis of the syndrome, is not entirely feasible. The most important is a multimodal approach to treat comorbid conditions such as diabetes mellitus type 2, obesity, hyperlipidemia, depression, and infertility.
Factors influencing the length of the recovery period after blepharoplasty: a review of the latest data
Authors: Nieć Maria , Olejarz Zuzanna , Nowak Karolina , Drygała Zuzanna , Wyrwał Julia , Zielińska Zuzanna , Słowik Magdalena , Nowak Karolina , Gierlach Katarzyna , Krasuska Martyna 
Published: February 2024

Introduction and purpose
Blepharoplasty is a surgical procedure aimed at restoring the functionality and/or aesthetics of the eyelids. The aim of the study is to draw attention to the factors influencing the recovery period at successive stages of therapeutic procedures.
A brief description of the state of knowledge:
Preoperative consultation is important in selecting patients, planning surgical procedures, identifying potential complications and meeting patients' expectations. In patients with hypertension, diabetes, smoking, and anticoagulant treatment, a worse scar assessment, longer recovery period and more complications have been observed. Patients who have undergone refractive surgery within the last 6 months are not suitable candidates for blepharoplasty. Nutrition status has a significant impact on wound healing and tissue repair after aesthetic medicine procedures. The use of continuous sutures compared to tissue glue results in similar wound healing time and postoperative discomfort level. Postoperative wound care is essential for the healing process. Electrostimulation of the wound does not accelerate edema reduction. We have focused on many complications, such as swelling, bleeding, infections, eyelid malposition, dry eye syndrome, wound dehiscence, ways to cope with these problems, and the role of lasers.
Summary (conclusions):
Important is the proper preparation of the patient for the procedure. A detailed interview and examination influence therapeutic decisions, allowing the doctor to choose the most optimal treatment methods that will shorten the recovery time. Blepharoplasty is one of the most commonly performed aesthetic procedures, so we propose the development of publicly accessible standards that should be included in the initial interview.
FrFT-based estimation of linear and nonlinear impairments using Vision Transformer
Authors: Jiang Ting , Gao Zheng , Chen Yizhao , Hu Zihe , Tang Ming 
Published: February 2024

To comprehensively assess the conditions of an optical fiber communication system, it
is essential to implement joint estimation of the following four
critical impairments: nonlinear signal-to-noise ratio (SNRNL), optical signal-to-noise ratio
(OSNR), chromatic dispersion (CD), and differential group delay (DGD).
However, current studies only achieve identifying a limited number of
impairments within a narrow range, due to a lack of high-performance
computing algorithms and a unified representation of impairments. To
address these challenges, we adopt time-frequency signal processing
based on the fractional Fourier transform (FrFT) to achieve the
unified representation of impairments, while employing a
Transformer-based neural network (NN) to break through network
performance limitations. To verify the effectiveness of the proposed
estimation method, numerical simulations were conducted on a
five-channel polarization-division-multiplexed quadrature phase shift
keying (PDM-QPSK) long haul optical transmission system with the
symbol rate of 50 GBaud per channel. The mean absolute error
(MAE) for SNRNL, OSNR, CD, and DGD estimation is
0.091 dB, 0.058 dB, 117 ps/nm, and
0.38 ps, and the monitoring window ranges from 0−20dB, 10−30dB, 1700−51,000ps/nm, and 0−100ps, respectively. Our proposed method
achieves accurate estimation of linear and nonlinear impairments over
a broad range, representing a significant advancement in the field of
optical performance monitoring (OPM).
Mannose and glycine: Metabolites with potentially causal implications in chronic kidney disease pathogenesis
Authors: Hu Yongzheng , Jiang Wei 
Published: February 2024

Background
Chronic Kidney Disease (CKD) represents a global health challenge, with its etiology and underlying mechanisms yet to be fully elucidated. Integrating genomics with metabolomics can offer insights into the putatively causal relationships between serum metabolites and CKD.

Methods
Utilizing bidirectional Mendelian Randomization (MR), we assessed the putatively causal associations between 486 serum metabolites and CKD. Genetic data for these metabolites were sourced from comprehensive genome-wide association studies, and CKD data were obtained from the CKDGen Consortium.

Results
Our analysis identified four metabolites with a robust association with CKD risk, of which mannose and glycine showed the most reliable causal relationships. Pathway analysis spotlighted five significant metabolic pathways, notably including "Methionine Metabolism" and "Arginine and Proline Metabolism", as key contributors to CKD pathogenesis.

Conclusion
This study underscores the potential of certain serum metabolites as biomarkers for CKD and illuminates pivotal metabolic pathways in CKD’s pathogenesis. Our findings lay the groundwork for potential therapeutic interventions and warrant further research for validation.
Nuevos datos y reflexiones sobre CILC IV 1159 (Grimaldo, Cáceres): ¿un miliario palimpsesto?
Authors: Paredes Martín Enrique 
Published: February 2024

El miliario CILC IV 1159 es uno de los más problemáticos de la comúnmente conocida como Vía de la Plata. Procedente de la localidad cacereña de Grimaldo y actualmente depositado en la Catedral de Plasencia, desde su descubrimiento y edición original este miliario lleva décadas planteando serios problemas en cuanto a su lectura y a su comprensión. Dado el deterioro de la pieza y lo irregular de su inscripción, han sido muy distintas las propuestas de restitución textual que se han dado a este hito por parte de diferentes investigadores, si bien lo cierto es que ninguna de ellas ha permitido una correcta comprensión de la inscripción en él grabada. No obstante, a través de un detallado estudio de la pieza, que ha conllevado por primera vez la elaboración de un calco del texto y la confección de distintos modelos fotogramétricos de la pieza por medio del software Agisoft Metashape, ofrecemos en estas páginas una nueva propuesta interpretativa, según la cual creemos estar en disposición de plantear que nos hallamos en realidad ante un miliario palimpsesto, es decir, un miliario cuya inscripción original fue parcialmente borrada para dar cabida a un segundo texto posterior. Esto permitiría explicar, en nuestra opinión, ciertas anomalías textuales que tantos problemas han planteado en la bibliografía previa acerca de este hito. Los escasos caracteres todavía apreciables de la primera inscripción y, sobre todo, la identidad del emperador nombrado en el segundo texto nos llevan a presentar la hipótesis de atribución de sendas inscripciones respectivamente al usurpador Magnencio y a Constancio II, pudiendo ofrecer, por tanto, un marco cronológico entre los años 350-353 (texto A) y 353-361 d. C. (texto B) para este problemático miliario.
A History of Gambyong: From Folk Art to Classical Dance. By Sri Rochana Widyastutieningrum. Translated by Maho Ishiguro, Rajendra Amira L.S., Sonia Pangesti Lambangsari, and Thow Xin Wei.
Authors: Ishiguro Maho , Widyastutieningrum Sri Rochana , Rajendra Amira L.S.  , Thow Xin Wei  , Lambangsari Sonia Pangesti 
Published: February 2024

Gambyong is a Central Javanese dance form with folk origins. Today, it is performed in royal courts, at opening ceremonies for official municipal events, as well as at other social events such as weddings, performing arts festivals, and the anniversaries of establishments. While gambyong developed within the two court cities of Yogyakarta and Surakarta, it is in the latter where the dance has been more prominently cultivated and woven into the social fabric of today. Infused with the aesthetics and prestige of the Central Javanese courts, gambyong characteristically portrays the elegance, amorousness, and alluring liveliness of its female dancers. In this monograph, Sri Rochana Widyastutieningrum discusses the history and recent developments of gambyong, the content and context of its performance, and its practice in the present day. The author also explores gambyong’s sociocultural values and symbolism, its educational value for women’s minds and souls, its aesthetics and philosophical underpinnings, and its musical accompaniment.
Citation: Widyastutieningrum, Sri Rochana. A History of Gambyong: From Folk Art to Classical Dance. Translated by Maho Ishiguro, Rajendra Amira L.S., Sonia Pangesti Lambangsari, and Thow Xin Wei. Ethnomusicology Translations, no. 14. Bloomington, IN: Society for Ethnomusicology, 2024.
Originally published as: Widyastutieningrum, Sri Rochana. Sejarah Tari Gambyong: Seni Rakyat Menuju Istana. Surakarta, Indonesia: Citra Etnika Surakarta, 2004.
To Bee, or Not to Bee: A Commentary on International Neonicotinoid Regulation
Authors: Sykes Cooper 
Published: February 2024

Amidst a time of dramatic climate change and exponential population growth, sustaining food production, and the pollinators essential to that production, has taken on increased importance. The current global system of industrial agriculture, however, relies on chemical pesticides, including neonicotinoids. A growing number of studies convincingly demonstrate that neonicotinoids are killing bees and their colonies. With bees and other pollinator populations in danger, an integral part of the world’s food system is at risk.
This paper focuses on the dangers of neonicotinoid use and the need for international neonicotinoid regulation. The paper analyzes the emergence of neonicotinoids in the global agrochemical market, their negative impact on the health of pollinators, and the current legal regulations that govern neonicotinoid use. It recommends greater use of multilateral, international agreements to more comprehensively regulate neonicotinoids to protect bees and other pollinator populations. Other environmental treaties, such as the Montreal Protocol and the Stockholm Convention, provide accessible frameworks for cooperative regulation. If international communities act quickly, there may still be time to sufficiently protect pollinator populations from further catastrophic harm from neonicotinoid use. Bees and other pollinators are essential for global food production, and this paper provides a path forward for policy-makers and law-makers to better protect these species from the harms of neonicotinoids.
Preparing to View the 2024 Total Eclipse Safely: A Video Article
Authors: McConnell Tom J. 
Published: February 2024

The total solar eclipse coming in April, 2024, is naturally drawing a great deal of attention from scientists, science educators, and casual science enthusiasts. Indiana is expected a large contingent of visitors from around the world for the event. Science educators can use this exciting natural phenomenon as teaching tool, and we can all look forward to a once-in-a-lifetime experience.
A partial eclipse in 2017 taught us some lessons about solar eclipse viewing with a public audience. One of those lessons is that school administrators tend to react with extreme caution when eclipses occur. Principals and superintendents across the state directed teachers to not let students go outside during the eclipse to avoid potential injuries from viewing the eclipse without proper safety precautions.
As a life-long science educator, the author suggests a different approach. With proper planning and preparation, including educating our school administrators, the 2024 total eclipse can be a fun and educational… and safe! The tools to view and eclipse safely are easy to find, and there are excellent materials that even young children can make and use at school, at home, or at a public eclipse viewing event.
To help teachers and administrators learn more about how to prepare for safe eclipse viewing, the science education community at Ball State University offers a video article. You can view the article by clicking the following link to the YouTube video:
Preparing to View the 2024 Total Eclipse Safely: A Video Article
The myopic focus on decoloniality in applied linguistics and English language education: citations and stolen subjectivities
Authors: Selvi Ali Fuad 
Published: February 2024

Abstract
The recent surge in acknowledging and critically engaging with identity, advocacy, social justice, criticality, anti-racism, and decolonization in applied linguistics has initiated a process aimed at destabilizing, disrupting, and eventually transforming the geopolitics of knowledge, epistemological orientations, ideological commitments, and methodological practices in research. The current study investigates the evolutionary trajectory of decoloniality in applied linguistics, specifically focusing on citation practices as a point of entry in knowledge building, theorization, and dissemination in major journals over the past 5 years. The findings uncover the consistent invisibility of scholars from the Global South as authors (who use their voices [in]form the knowledge building and dissemination), cited authors (whose voices are used to [in]form the knowledge building and dissemination), and editors/editorial board members (whose vision and practices that ultimately [in]form disciplinary norms, expectations, and directions about knowledge building and dissemination). These (in)advertent (self-) exclusionary trends relegate Southern voices, subjectivities, and epistemological perspectives, perpetuating the dominance of the Anglosphere and obscuring ongoing epistemic appropriation. It concludes that resisting epistemic injustices (erasure, silence, and theft) must be regarded as an ethical, ideological, and professional imperative and demand the deployment of rhetorical strategies, equitable citation practices, collaborative initiatives, and a sustained commitment to decolonial skepticism.