bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost implications of closure of atrial septal defect
Authors: Baker Sherri S. , O'Laughlin Martin P. , Jollis James G. , Harrison J. Kevin , Sanders Stephen P. , Li Jennifer S. 
Published: August 2002

AbstractWe sought to evaluate the relative cost of surgical and device closure of atrial septal defect. Device closure for atrial septal defects is becoming an alternative to surgical closure. We examined the hospital‐generated cost data in 13 patients who underwent surgical repair and 15 patients who underwent device closure of an atrial septal defects (ASD) or patent foramen ovale (PFO) during a prospective clinical trial of the device. The cost of device closure of ASD was $7,837 less on average than surgical closure when the cost of the occlusion device was excluded (device closure cost $7,397 ± $2,822, surgical closure cost $15,234 ± $3,851; P < 0.001). When adjusted for a 5% failure rate of device closure, the cost savings was $7,076. Device closure of ASD results in substantial hospital‐related cost savings that will be an important consideration once new devices are approved for clinical use. Cathet Cardiovasc Intervent 2002;55:83–87. © 2002 Wiley‐Liss, Inc.
Sequential vs. kissing balloon angioplasty for stenting of bifurcation coronary lesions
Authors: Brueck Martin , Scheinert Dierk , Flachskampf Frank A. , Daniel Werner G. , Ludwig Josef 
Published: August 2002

AbstractCoronary angioplasty of bifurcation lesions remains a technical challenge and is believed to result in low procedural success associated with the risk of side‐branch occlusion. Furthermore, long‐term results are associated with a high rate of reintervention. The aim of the study was to evaluate the immediate and long‐term clinical and angiographic results of sequential vs. simultaneous balloon angioplasty (kissing balloon technique) for stenting of bifurcation coronary lesions. Between December 1999 and January 2001, 59 patients underwent coronary angioplasty because of symptomatic bifurcation lesions type III (i.e., side branch originates from within the target lesion of the main vessel, and both main and side branch are angiographically narrowed more than 50%). Twenty‐six patients were treated with simultaneous and 33 patients with sequential balloon angioplasty. Main‐vessel stent placement was mandatory; side‐branch stenting and platelet IIb/IIIa antagonists were allowed at the discretion of the operator. Kissing balloon technique offered no advantage in terms of procedural success or need for repeat target vessel revascularization due to restenosis at 6‐month follow‐up. Using sequential balloon angioplasty, permanent or transient side‐branch compromise rate (TIMI flow < 3) was significantly higher than after kissing balloon technique (33% vs. 0%, respectively; P = 0.003). Major clinical events in‐hospital or at 6‐month follow‐up, however, showed no significant differences. Kissing balloon angioplasty reduces the rate of transient side‐branch occlusion compared to sequential PTCA but does not improve immediate or long‐term outcome compared to sequential PTCA for stenting of bifurcation lesions. Cathet Cardiovasc Intervent 2002;55:461–466. © 2002 Wiley‐Liss, Inc.
Percutaneous reperfusion of left main coronary disease complicated by acute myocardial infarction
Authors: Neri Roberto , Migliorini Angela , Moschi Guia , Valenti Renato , Dovellini Emilio Vincenzo , Antoniucci David 
Published: August 2002

AbstractPrevious studies have shown a benefit of a strategy of direct angioplasty and stenting in patients with acute myocardial infarction (AMI) complicated by early cardiogenic shock. However, few data exist for the subset of patients with left main trunk disease complicated by AMI and cardiogenic shock. We performed an analysis of patients with AMI who underwent mechanical intervention between January 1995 and December 2000. Out of 1,433 patients with ST segment elevation AMI treated with primary coronary angioplasty (PTCA), 22 patients (1.5%) had left main disease (LMD) as the culprit lesion. Baseline characteristics were age, 66 ± 11 years; female gender, 9%; diabetes, 14%; previous myocardial infarction, 14%; mean systolic blood pressure, 77 ± 24 mm Hg; time to treatment, 4.8 ± 2.2 hr; TIMI 0–1, 77%; collateral flow (Rentrop grade ≥ 2) 9%. The primary success rate was 91%. Primary stenting was performed in 17 patients (77%). The in‐hospital mortality rate was 50%. All deaths were due to refractory shock. The 6‐month survival rate was 41% ± 1%, while the event‐free survival rate was 27% ± 10%. At 6‐month follow‐up, the mortality rate increased to 59%; the target vessel revascularization rate was 14%. A percutaneous mechanical intervention strategy in patients with left main disease complicated by AMI is feasible and effective, and patients discharged alive have a good mid‐term prognosis. Cathet Cardiovasc Intervent 2002;56:31–34. © 2002 Wiley‐Liss, Inc.
Evaluation of diastolic function
Authors: Applegate Robert J. , Rankin Kevin M. , Powers John C. , Little William C. 
Published: August 2002

AbstractAbnormalities of diastolic function are increasingly recognized as important components of the abnormal physiology in many patients with heart failure. In order to better understand the role of abnormalities of individual parameters or diastolic function affecting filling of the left ventricular a broader understanding of the relationship of systolic and diastolic performance on overall left ventricular pump performance should be considered. While measurement of diastolic function noninvasively has become the predominant way of assessing diastolic performance, invasive evaluation remains important. Moreover, understanding the physiology of diastolic performance remains essential to proper diagnosis and management. Cathet Cardiovasc Intervent 2001;53:85–93. © 2001 Wiley‐Liss, Inc.
Late (> 48 hr) myocardial infarction after PTCA: Clinical and angiographic characteristics of infarction related or not to the angioplasty site
Authors: Rodés Josep , Tanguay Jean‐François , Bertrand Olivier F. , Malekianpour Mehrdad , Lespérance Jacques , Côté Gilles , Théroux Pierre 
Published: August 2002

AbstractSince late myocardial infarctions after percutaneous coronary interventions have not been well characterized, we intended to evaluate the characteristics of myocardial infarctions occurring > 48 hr after balloon angioplasty of native coronary arteries or saphenous vein grafts. The Montreal Heart Institute database (1985–1996) was interrogated for all patients readmitted with a diagnosis of MI more than 48 hr after successful percutaneous transluminal coronary angioplasty (PTCA). We compared the clinical, procedural, and angiographic variables between MIs related or not to the index PTCA site. One hundred and ninety‐three patients presented with late myocardial infarction (MI) following balloon angioplasty. The median time elapsed between PTCA and MI was 55 days compared to 968 days when MI was unrelated to the PTCA site. MIs related to the PTCA site were more likely non–Q‐wave (76% vs. 35%, P = 0.0001) with less marked CK‐MB rise. Angiography showed less complex lesions (63% vs. 90%, P = 0.001) and better thrombolysis in myocardial infarction (TIMI) grade flow (TIMI II to III, 66% vs. 56%, P = 0.01) when the culprit lesion was at the PTCA site. Independent predictors of MI at the PTCA site were vein graft dilation, female sex, and residual stenosis post‐PTCA. Myocardial infarctions occurring late after PTCA have a distinct time course and present specific characteristics according to their relationship or not to the previously dilated site. Cathet Cardiovasc Intervent 2001;53:155–162. © 2001 Wiley‐Liss, Inc.
Three‐year follow‐up after rotational atherectomy for the treatment of diffuse in‐stent restenosis: Predictors of major adverse cardiac events
Authors: Radke Peter W. , vom Dahl Juergen , Hoffmann Rainer , Klues Heinrich G. , Hosseini Massud , Janssens Uwe , Hanrath Peter 
Published: August 2002

AbstractRestenosis remains the major limitation of coronary stent implantation, especially in diffuse forms of in‐stent restenosis. In this study, rotablation (RA) with adjunct angioplasty of in‐stent restenosis was performed in 84 patients. Clinical follow‐up and control angiography were obtained 6‐month postprocedure. The rate of recurrent restenosis after rotablation for in‐stent restenosis at 6‐month angiographic follow‐up was 45%, resulting in a rate of major adverse cardiac events of 35%. At 3‐year follow‐up, the cumulative event‐free survival rate was 57% for the entire population. The only predictor of MACE at 3‐year clinical follow‐up by multivariate logistic regression analysis was in‐stent lesion length. RA for the treatment of diffuse in‐stent restenosis is thereby characterized by high procedural success rates and recurrent angiographic restenosis in 45% of patients with diffuse lesions. Major adverse cardiac events occur most likely within the first 6 months postprocedure. Three years after rotablation of in‐stent restenosis, 43% of patients had experienced at least one major adverse cardiac event. Cathet Cardiovasc Intervent 2001;53:334–340. © 2001 Wiley‐Liss, Inc.
Inadvertent stent extraction six months after implantation by an entrapped cutting balloon
Authors: Harb Tareq S. , Ling Frederick S. 
Published: August 2002

AbstractWe report a case of extraction of a restenosed aorto‐ostial stent by an entrapped cutting balloon that had inadvertently been passed through a protruding stent cell. Cathet Cardiovasc Intervent 2001;53:415–419. © 2001 Wiley‐Liss, Inc.
Initial results of the quanam drug eluting stent (QuaDS‐QP‐2) registry (BARDDS) in human subjects
Authors: de la Fuente Luis M. , Miano Jorge , Mrad Jorge , Penaloza Eduardo , Yeung Alan C. , Eury Robert , Froix Michael , Fitzgerald Peter J. , Stertzer Simon H. 
Published: August 2002

AbstractThirty‐two patients presenting with varied coronary syndromes and anatomy were treated with a new coronary multisleeve drug delivery coronary stent (QuaDS‐QP‐2) containing up to 4,000 μg of a taxol‐derived lipophilic microtubule inhibitor (QP2). The device was successfully implanted in 32 patients who have been followed for up to 2 years. Twenty‐five patients have undergone stress ECHO or SPECT Thallium and all are currently asymptomatic. Thirteen patients have already been restudied angiographically, by IVUS and/or by SPECT Thallium testing and are detailed in this report. Angiographic, IVUS, and SPECT Thallium have been controlled at a mean of 11.2 months (range, 6–15 months) in this 13‐patient cohort. Although all 13 QuaDS‐QP‐2 (QDES) stents were angiographically and IVUS patent, two reinterventions have been required in the 32‐patient study group thus far, both relate to either new disease or to distal, small‐vessel disease beyond the stent. There was no evidence of significant proliferation in the QDES devices. On the basis of this preliminary data and a European pilot study, a controlled randomized trial (SCORE) is currently in progress in western Europe. Cathet Cardiovasc Intervent 2001;53:480–488. © 2001 Wiley‐Liss, Inc.
Long‐term clinical safety and efficacy of NIROYAL vs. NIR intracoronary stent
Authors: Harding Scott A. , McKenna Charles J. , Flapan Andrew D. , Boon Nicholas A. 
Published: August 2002

AbstractResearch in vitro and in animal models suggested that gold electroplating of stents can attenuate neointimal hyperplasia and reduce thrombogenicity. The objective of this study was to evaluate the safety and efficacy of the gold‐coated NIROYAL stent in the treatment of stenosed coronary arteries and bypass grafts. We retrospectively studied 181 consecutive patients undergoing deployment of NIR (n = 87) or NIROYAL (n = 94) coronary stents in a single tertiary referral center from July 1997 to December 1998. Mean follow‐up duration for the NIR and NIROYAL patient groups were 11.6 and 11.4 (range, 3–12) months, respectively. Stent thrombosis rates were 3/87 (3%) in the NIR and 0/94 (0%) in the NIROYAL group (P = 0.07). The need for target lesion revascularization (TLR) in the NIR patient group was 8/87 (9%) compared to 11/94 (12%) in the NIROYAL patient group (P = 0.6). The overall MACE rates for the NIR and NIROYAL patient groups were 24/87 (28%) and 22/94 (23%), respectively (P = 0.5). The present study, hence, implies equivalence between the stainless steel NIR and the gold‐plated NIROYAL stent with no significant difference in immediate and long‐term clinical performance profiles. Cathet Cardiovasc Intervent 2001;54:141–145. © 2001 Wiley‐Liss, Inc.
Subarachnoidal hemorrhage following carotid stenting with the distal‐balloon protection
Authors: Al‐Mubarak Nadim , Roubin Gary S. , Vitek Jiri J. , Iyer Sriram S. , New Gishel , Leon Martin B. 
Published: August 2002

AbstractA 61‐year‐old man underwent carotid stenting with the distal‐balloon protection system for symptomatic carotid artery stenosis. During the procedure, progressive elevation of the systolic blood pressure occurred, reaching a peak of 220 mm Hg immediately following deflation of the distal balloon. This was associated with severe headaches and progressive deterioration in the mental status to a coma. Head CT scan showed massive subarachnoidal hemorrhage contralateral to the stented side and a secondary intracerebral hemorrhage. Despite immediate successful blood pressure control, his condition deteriorated and he died 2 days later. Cathet Cardiovasc Intervent 2001;54:521–523. © 2001 Wiley‐Liss, Inc.
Sequence search algorithms for single pass sequence identification: does one size fit all?
Authors: Cara Woodwark K. , Hubbard Simon J. , Oliver Stephen G. 
Published: August 2002

AbstractBioinformatic tools have become essential to biologists in their quest to understand the vast quantities of sequence data, and now whole genomes, which are being produced at an ever increasing rate. Much of these sequence data are single‐pass sequences, such as sample sequences from organisms closely related to other organisms of interest which have already been sequenced, or cDNAs or expressed sequence tags (ESTs). These single‐pass sequences often contain errors, including frameshifts, which complicate the identification of homologues, especially at the protein level. Therefore, sequence searches with this type of data are often performed at the nucleotide level. The most commonly used sequence search algorithms for the identification of homologues are Washington University's and the National Center for Biotechnology Information's (NCBI) versions of the BLAST suites of tools, which are to be found on websites all over the world. The work reported here examines the use of these tools for comparing sample sequence datasets to a known genome. It shows that care must be taken when choosing the parameters to use with the BLAST algorithms. NCBI's version of gapped BLASTn gives much shorter, and sometimes different, top alignments to those found using Washington University's version of BLASTn (which also allows for gaps), when both are used with their default parameters. Most of the differences in performance were found to be due to the choices of default parameters rather than underlying differences between the two algorithms. Washington University's version, used with defaults, compares very favourably with the results obtained using the accurate but computationally intensive Smith–Waterman algorithm. Copyright © 2001 John Wiley & Sons, Ltd.
Asymmetric induction in the [4+2]cycloaddition of cyclopentadiene and furan to chiral derivatives of fumaric acid
Authors: Kucharska Anna , Gorczyńska Renata , Chapuis Christian , Jurczak Janusz 
Published: August 2002

Abstract[4+2]Cycloaddition reactions of cyclopentadiene (1a) and furan (1b) to N,N′‐fumaroyldi[(2R)‐bornane‐10,2‐sultam] (2) and to N,N′‐fumaroyldi[(2R)‐bornane‐10,2‐(2′‐phenyl‐pyrazol‐3′‐one)] (3) are presented. A correlation between the solvent polarity and the logarithm of the diastereoisomer ratio (dr) was found for the uncatalyzed [4+2]cycloaddition of 1a to 3. Chirality 13:631–633, 2001. © 2001 Wiley‐Liss, Inc.
Alkylating agents from sugars: Synthesis of chlorambucil derivatives carried by chiral glycosyl glycerols derived from D‐Glucosamine
Authors: Iglesias‐Guerra Fernando , Candela José I. , Blanco Eugenia , Alcudia Felipe , Vega‐Pérez José M. 
Published: August 2002

AbstractChlorambucilamide derivatives involving chiral glycosyl glycerols derived from D‐glucosamine were synthesized in good yield by coupling the chlorambucil moiety to the amino group of ω‐amino‐(ω‐1)‐hydroxyalkyl 2‐acylamino‐4,6‐O‐benzylidene‐2‐deoxy‐β‐D‐glucopyranosides, and subsequent hydrolysis of the benzylidene group. The starting material was easily available from 2‐acetamido‐2‐deoxy‐D‐glucose. The bonding of 2,3,4,6‐tetra‐O‐pivaloyl‐β‐D‐galactopyranosylamine to chlorambucil by formation of an amide function is also described. Chirality Chirality 14:199–203, 2002. © 2002 Wiley‐Liss, Inc.
Synthesis and stereochemistry of dispiro substituted pyridazines: Application of ellipticity‐absorbance ratio spectra for proving enantiomeric relationship by HPLC‐CD/UV detection
Authors: Beke Gyula , Gergely András , Szász György , Szentesi Aletta , Nyitray József , Barabás Orsolya , Harmath Veronika , Mátyus Péter 
Published: August 2002

AbstractThe aim of our study was to synthesize vinylic and pyrido‐fused pyridazines with a spirano moiety and to investigate their stereochemistry by spectroscopic and HPLC analyses. The vinylic compounds 5 were obtained by Knoevenagel condensation of cyclohexylidene malonates 1 with pyridazinecarbaldehyde 2. Compound 5b exhibits geometric isomerism identified by NMR, HPLC, and X‐ray methods. The thermal rearrangement reactions of compounds 5 easily led to the pyridopyridazine derivatives 6. In the case of 6b, possessing both central and axial chirality, both diastereomers and the respective enantiomers were detected. Their stereochemical relationships could be determined by HPLC‐CD/UV analyses with application of anisotropy spectra in a novel way. Chirality 14:365–371, 2002. © 2002 Wiley‐Liss, Inc.
Evaluation of the contribution to enantioselectivity of quinine and quinidine scaffolds in chemically and physically mixed chiral selectors
Authors: Franco Pilar , Klaus Philipp M. , Minguillón Cristina , Lindner Wolfgang 
Published: August 2002

AbstractThree “dimeric” C9‐carbamates of quinine (QN) and quinidine (QD), that is, QN‐QN, QD‐QD, and QN‐QD (chemically prepared mixture of the two cinchona‐derived subunits), separated by an ethylene spacer were synthesized and used as chiral selectors for HPLC and capillary electrophoresis (CE) for the resolution of chiral acids. The chiral recognition abilities of these dimers and of several physically prepared mixtures thereof were compared in order to estimate the contribution of every cinchona scaffold to the overall enantioselectivity. The diverse phenomena observed in nonaqueous capillary electrophoresis (NACE), either using the selector added to the background electrolyte (BGE) in the total filling or partial filling mode, led us to rationalize, taking into account the relative mobilities of the chiral selectors in the capillary. The chromatographic and electrophoretic properties were compared with those of the corresponding “monomeric” QN and QD carbamates. Chirality 13:177–186, 2001. © 2001 Wiley‐Liss, Inc.
First direct discrimination of chiral phosphorus thionate (P=S) derivatives by multinuclear magnetic resonance spectroscopy in the presence of a chiral dirhodium complex
Authors: Rockitt Sven , Duddeck Helmut , Omelanczuk Jan 
Published: August 2002

AbstractEnantiomeric ratios of compounds with P=S functionalities can be determined by 1H, 13C, and 31P NMR spectroscopic inspection of their diastereomeric complexes with (r)‐Rh2(MTPA)4 (MTPA‐H ≡ methoxytrifluoromethylphenylacetic acid; Mosher's acid). This is the first facile and rapid spectroscopic method for chiral recognition in this class of compounds. Whereas complexation shifts Δδ are moderate or even negligible, significant signal dispersions Δν can be observed. Some rationalization about the complexation mode is presented. The NMR spectral characteristics of the free P=S compounds 1–9 are described in detail. Chirality 13:214–222, 2001. © 2001 Wiley‐Liss, Inc.
Solid‐phase synthesis of chiral stationary phases based on 2,4,5,6‐tetrachloro‐1,3‐dicyanobenzene derivatives spaced from N‐3,5‐dinitrobenzoyl α‐amino acids: Comparative study of their resolution efficacy
Authors: Kontrec Darko , Abatangelo Anna , Vinković Vladimir , Šunjić Vitomir 
Published: August 2002

AbstractTwo new chiral stationary phases, 3‐[5‐chloro‐1,3‐dicyano‐2,4‐[2′‐(N′‐1,3‐dinitrobenzoyl‐D‐phenylglycinyl) aminoethyl]aminophen‐1‐yl] aminopropyl silica (CSP‐1) and 3‐[5‐chloro‐1,3‐dicyano‐2,4‐[2′‐(N′‐1,3‐dinitrobenzoyl‐L‐leucinyl) aminoethyl] aminophen‐1‐yl] aminopropyl silica (CSP‐2), were prepared by solid‐phase synthesis. They comprise chiral unit, 3,5‐dinitrobenzoyl derivative of the amino acid, D‐PhGly or L‐Leu, bound via spacer 1,2‐diaminoethane to 2,4‐positions of the persubstituted benzene ring, derived from compound 1, and possess pseudo‐C2 symmetry. Preparation of model compounds 6 and 7 confirmed the structure of chiral selectors, which comprise π‐donor persubsituted aromatic ring and two strong π‐acceptor 3,5‐dinitrobenzoyl amido units. CD spectra of model selectors 6 and 7, run in DMSO above 250 nm, exhibit negative exciton coupling (EC) between π‐acceptor and π‐donor chromophores, C1 symmetric model compound 8 exhibited much weaker EC and 9, devoid of π‐donor unit, does not exhibit any significant CD. Combined π‐donor and π‐acceptor properties enable the new CSPs to separate a broad range of racemates. The columns with CSP‐1 and CSP‐2 were tested for the separation of 22 racemates by HPLC with two different mobile phase systems and the results are compared with those obtained by using a structurally related commercial column. Chirality 13:294–301, 2001. © 2001 Wiley‐Liss, Inc.
Absolute stereochemistry of guaianolides, of matricin and its epimers, of yarrow proazulenes, and of chamazulene carboxylic acid
Authors: Imming Peter , Goeters Susanne , Pawlitzki Gregor , Hempel Bernd 
Published: August 2002

AbstractKnown determinations of the absolute configuration of guaianolides were collected and found to be few. The absolute configurations of guaianolides rest on the assumption that 7‐H always has α‐orientation. For matricin, only the relative configuration was determined. On the basis of a detailed study of the NMR spectra of matricin and its epimers, and of synthetic, NMR, and CD studies with its decomposition product, chamazulene carboxylic acid, we were able to reconfirm the accepted 3S,3aR,4S,9R,9aS,9bS configuration of matricin. Chirality 13:337–341, 2001. © 2001 Wiley‐Liss, Inc.
Novel asymmetric oxy‐michael addition reaction of the chiral ketones to the achiral γ‐ or δ‐hydroxy‐α,β‐unsaturated carbonyl compounds
Authors: Watanabe Hidenori , Machida Kaori , Itoh Daisuke , Nagatsuka Haruki , Kitahara Takeshi 
Published: August 2002

AbstractA novel asymmetric oxy‐Michael addition reaction was developed. In the presence of a catalytic amount of base, chiral ketones 1 and 2, derived from D‐glucose and D‐fructose, respectively, reacted with ω‐hydroxy enones or enoates 3a–e, 17 and 21 to form the hemiacetal‐derived alkoxide which underwent stereoselective intramolecular Michael addition to give cyclic acetals. Although the stereoselectivities in the formation of the five‐membered acetal rings were modest, six‐membered ring formation proceeded with high stereoselectivity and the utility of the reaction was demonstrated by a simple syntheses of natural products. Chirality 13:379–385, 2001. © 2001 Wiley‐Liss, Inc.