bluuebunny/crossref_metadata_2025_split huggingface dataset:
The new corruption crusaders: Security sector ties as an anti-corruption voting heuristic
Authors: Vilaça Luiz , Turner Jacob R. 
Published: January 2024

AbstractDespite the salience of corruption in elections in Latin America and beyond, it remains unclear what makes certain candidates attractive to voters as solutions to address corruption. Building on studies about the effect of candidates’ professional affiliation on voting behavior, we hypothesize that police and military officers are perceived to be more competent to address corruption. We test our theoretical expectations through an online survey of Brazilian voters with an image-based factorial experiment that presents respondents with three randomly generated handbills, varying candidates’ professional affiliations and potential confounders, such as economic policy, insider versus outsider status, and demographic features. Our results demonstrate that candidates affiliated with the police or the military are perceived to be more effective at reducing corruption, all else equal. The effect of police or military professions on candidates’ perceived effectiveness to fight corruption varies according to respondents’ ideology and is particularly significant among conservative voters.
Vote Choices and Valence: Intercepts and Alternate Specifications
Authors: Mauerer Ingrid , Tutz Gerhard 
Published: January 2024

AbstractValence is a crucial concept in studying spatial voting and party competition. The widely adopted approach is to rely on intercepts of vote choice models and to infer, based on their size and direction, how valence affects party strategies in empirical settings. The approach suffers from fundamental statistical flaws. This contribution provides the statistical fundamentals to advance the empirical modeling of valence. It proposes an appropriate modeling approach to interpret intercepts as valences and alternate specifications to parameterize the effects of valence.
Palaeoparasitology confirms Early Lapita evidence of pig and dog at Kamgot, Bismarck Archipelago
Authors: Horrocks M. , Summerhayes G. , Presswell B. 
Published: January 2024

Abstract
Little is known about helminth parasites of the Bismarck Archipelago, in either archaeological or modern contexts. This study presents a parasitological analysis of soil samples from Early Lapita habitation layers at Kamgot (3300–3000 BP). Evidence for the presence of pigs and dogs and the timing of their arrival in Early Lapita contexts have been contested in the literature. The finding of parasite eggs in samples from Kamgot supports the presence of pigs and dogs at the site. Six types of helminth eggs were identified: pig nematode Trichuris suis, dog nematode Toxocara canis, and cestode Dipylidium caninum, as well as two unknown trematodes and a possible anoplocephalid cestode, thereby indicating the local presence of other mammals or birds. This study represents the first confirmed record of ancient helminth parasites in tropical Oceania.
A critique of motivation constructs to explain higher-order behavior: We should unpack the black box
Authors: Murayama Kou , Jach Hayley K. 
Published: January 2024

Abstract
The constructs of motivation (or needs, motives, etc.) to explain higher-order behavior have burgeoned in psychology. In this article, we critically evaluate such high-level motivation constructs that many researchers define as causal determinants of behavior. We identify a fundamental issue with this predominant view of motivation, which we call the black-box problem. Specifically, high-level motivation constructs have been considered as causally instigating a wide range of higher-order behavior, but this does not explain what they actually are or how behavioral tendencies are generated. The black-box problem inevitably makes the construct ill-defined and jeopardizes its theoretical status. To address the problem, we discuss the importance of mental computational processes underlying motivated behavior. Critically, from this perspective, motivation is not a unitary construct that causes a wide range of higher-order behavior – it is an emergent property that people construe through the regularities of subjective experiences and behavior. The proposed perspective opens new avenues for future theoretical development, that is, the examination of how motivated behavior is realized through mental computational processes.
Voluntary and Involuntary Migrants: On Migration, Safe Third Countries, and the Collective Unfreedom of the Proletariat
Authors: Blake Michael 
Published: January 2024

AbstractThe claims of those who are compelled to migrate are, in general, taken to be more urgent and pressing than the claims of those who were not forced to do so. This article does not defend the moral relevance of voluntarism to the morality of migration, but instead seeks to demonstrate two complexities that must be included in any plausible account of that moral relevance. The first is that the decision to start the migration journey is distinct from the decision to stop that journey, through resettlement; the latter may involve voluntary choice, without that voluntarism impugning the involuntary nature of the former. The second is that the migration decision of the individual might be voluntary, even while that individual's family or social network might be compelled to insist upon some particular individual member's migration. That is, the fact that any particular person might be free to refuse migration does not contradict the fact that the group in question does not have the effective freedom to avoid the migration of some group members. Once these two complexities are understood, I argue, the moral relevance of voluntarism in the ethics of migration becomes more complex and nuanced than is generally understood.
International Law and the Humanization of Warfare
Authors: Regan Mitt 
Published: January 2024

AbstractThe trend toward the “humanization” of international law reflects a greater emphasis on individuals rather than simply states as objects of concern. The advance of human rights law (HRL) has been an important impetus for this trend. Some observers suggest that humanization can be furthered even more by applying HRL rather than international humanitarian law (IHL) to hostilities between states and nonstate armed groups, unless a state explicitly declares that it is engaged in an armed conflict. This essay argues, however, that a court should not defer to a state's characterization of hostilities, but should base its analysis on whether hostilities meet the criteria for an armed conflict. Applying HRL to hostilities that effectively are an armed conflict but not acknowledged as such risks diluting the legitimacy and normative force of HRL. On the one hand, if a court applies conventional stringent HRL standards, this body of law may be seen as unrealistic and is likely to be ignored. On the other hand, a court that adapts HRL standards to armed conflict may need to take a consequentialist approach at odds with HRL's deontological foundations. Clearly differentiating between HRL and IHL may thus best promote the humanization of warfare.
Maternal pea fiber supplementation to a high calorie diet in obese pregnancies protects male offspring from metabolic dysfunction in adulthood
Authors: Andreani Gabriella A. , Mahmood Saleh , Patel Mulchand S. , Rideout Todd C. 
Published: January 2024

AbstractWe investigated the influence of maternal yellow-pea fiber supplementation in obese pregnancies on offspring metabolic health in adulthood. Sixty newly-weaned female Sprague-Dawley rats were randomized to either a low-calorie control diet (CON) or high calorie obesogenic diet (HC) for 6-weeks. Obese animals were then fed either the HC diet alone or the HC diet supplemented with yellow-pea fiber (HC + FBR) for an additional 4-weeks prior to breeding and throughout gestation and lactation. On postnatal day (PND) 21, 1 male and 1 female offspring from each dam were weaned onto the CON diet until adulthood (PND 120) for metabolic phenotyping. Adult male, but not female, HC offspring demonstrated increased body weight and feed intake vs CON offspring, however no protection was offered by maternal FBR supplementation. HC male and female adult offspring demonstrated increased serum glucose and insulin resistance (HOMA-IR) compared with CON offspring. Maternal FBR supplementation improved glycemic control in male, but not female offspring. Compared with CON offspring, male offspring from HC dams demonstrated marked dyslipidemia (higher serum cholesterol, increased number of TG-rich lipoproteins, and smaller LDL particles) which was largely normalized in offspring from HC + FBR mothers. Male offspring born to obese mothers (HC) had higher hepatic TG, which tended to be lowered (p = 0.07) by maternal FBR supplementation.Supplementation of a maternal high calorie diet with yellow-pea fiber in prepregnancy and throughout gestation and lactation protects male offspring from metabolic dysfunction in the absence of any change in body weight status in adulthood.
Rights of Nature on the Island of Ireland: Origins, Drivers, and Implications for Future Rights of Nature Movements
Authors: Killean Rachel , Gilbert Jérémie , Doran Peter 
Published: January 2024

AbstractOver the course of 2021, several local councils across the island of Ireland introduced motions recognizing the ‘Rights of Nature’. To date, little research has been conducted into these nascent Rights of Nature movements, even though they raise important questions about the philosophical, cultural, political, and legal drivers in pursuing such rights. Similarly, much remains unclear as to the implications of such initiatives, both in their domestic context and for Rights of Nature movements around the world. This article contributes to addressing this gap by exploring these themes through an analysis of interviews with key stakeholders conducted across the island of Ireland in June 2022. In particular, it explores the impact of international movements, colonial legacies, cultural heritage, and years of inadequate environmental governance, in motivating local councils to pursue a Rights of Nature strategy.
Coupling Physical Factors for Precipitation Forecast in China With Graph Neural Network
Authors: Chen Yutong , Wang Ya , Huang Gang , Tian Qun 
Published: January 2024

AbstractPrecipitation exerts far‐reaching impacts on both socio‐economic fabric and individual well‐being, necessitating concerted efforts in accurate forecasting. Deep learning (DL) models have increasingly demonstrated their prowess in forecasting meteorological elements. However, traditional DL prediction models often grapple with heavy rainfall forecasting. In this study, we propose physics‐informed localized graph neural network models called ω‐GNN and ω‐EGNN, constrained by the coupling of physical variables and climatological background to predict precipitation in China. These models exhibit notable and robust improvements in identifying heavy rainfall while maintaining excellent performance in forecasting light rain by comparing to numerical weather prediction (NWP) and other DL models with multiple perturbation experiments in different data sets. Surprisingly, within a certain range, even when a DL model utilizes more input variables, GNN can still maintain its advantage. The methods to fuse physics into DL model demonstrated in this study may be promising and call for future studies.
Weakened Increase in Global Near‐Surface Water Vapor Pressure During the Last 20 Years
Authors: Xu Wenfang , Xia Xiaosheng , Piao Shilong , Wu Donghai , Li Weibiao , Yang Song , Yuan Wenping 
Published: January 2024

AbstractIt is well known that global warming increases the atmospheric water vapor content, which results in substantial changes in the hydrological cycle. Using five observational data sets, the results show that an increasing trend of near‐surface water vapor pressure (AVP) over land and ocean was significant from 1975 to 1998, while such an increasing trend in AVP subsequently weakened from 1999 to 2019. This phenomenon is associated with decreased oceanic evaporation and land surface evapotranspiration in response to recent climate variations. One consequence of such a phenomenon is a large increase in near‐surface vapor pressure deficit (VPD), which in turn increases atmospheric demand for water vapor and thus aridity and drought over land. This result emphasizes the importance of water vapor change under global warming.
Coupled Transport, Reactivity, and Mechanics in Fractured Shale Caprocks
Authors: Murugesu M. P. , Vega B. , Ross C. M. , Kurotori T. , Druhan J. L. , Kovscek A. R. 
Published: January 2024

AbstractShales are low‐permeability caprocks that confine fluid, such as CO2, nuclear waste, and hydrogen, in storage formations. Stress‐induced fractures in shale caprocks provide pathways for fluid to leak and potentially contaminate fresh water aquifers. Fractured shales are also increasingly considered as resources for CO2 sequestration, enhanced geothermal, and unconventional energy recovery. Injecting reactive fluids into shales introduces chemical disequilibrium, causing an onset of a series of dissolution, precipitation, and fines mobilization mechanisms. The reactions have rapid kinetics and significant impact on porosity and permeability; consequently, flow and storage properties of caprocks. While previous research has explored the separate effects of these reactions, this study aims to uncover their simultaneous occurrence and collective influence. This study unveils these highly coupled transport and reactivity mechanisms by tracking and visualizing the reaction‐induced alterations in the matrix, microcracks, and fractures of shales over time. We conducted brine injection experiments sequentially at pH 4 and 2 in a naturally fractured Wolfcamp shale sample while simultaneously imaging the dynamic processes using X‐ray computed tomography (CT). CT images are validated by finer resolution images obtained using micro‐CT and scanning electron microscopy. We also tracked the sample permeability and fluid chemistry using brine permeability and inductively coupled plasma mass spectrometry, respectively. Findings show that fluid primarily flowed through fractures, dissolving reactive minerals and mobilizing fines on fracture surfaces. Dissolution of fracture asperities under confining stress resulted in the closing of fractures. Clogging in narrow fracture pathways, caused by fines accumulation, diverted fluid flow into matrix pores.
Waveguide-based augmented reality displays: a highlight
Authors: Rolland Jannick P. , Goodsell Jeremy 
Published: January 2024

AbstractAugmented reality (AR), which emerged in the 1960s, remains a focal point of interest given its capacity to overlay the real world with digitally presented information through optical combiners. The prevalent combiner, commonly known as the waveguide in the AR literature, is prized for its compact design and generous eyebox—essential elements in human-centric technology. Nonetheless, these combiners encounter unique challenges in meeting various other requirements of the human visual system. This paper highlights a recent review of technological advancements and presents a forward-looking perspective on the future of AR technology.
One thousand patients with essential thrombocythemia: the Florence-CRIMM experience
Authors: Loscocco Giuseppe G. , Gesullo Francesca , Capecchi Giulio , Atanasio Alessandro , Maccari Chiara , Mannelli Francesco , Vannucchi Alessandro M. , Guglielmelli Paola 
Published: January 2024

AbstractWe describe 1000 patients with essential thrombocythemia seen at the Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Florence, Italy, between 1980 and 2023: median age 59 years (18–95), females 65%, JAK2/CALR/MPL-mutated 66%/19%/4%, triple-negative (TN) 11%. Extreme thrombocytosis (ExT, platelets ≥1000 × 109/L) in 16%, leukocytosis (leukocytes >11 × 109/L) in 16%, and at least one cardiovascular risk factor in 52% of cases. JAK2-mutated patients were older (median 62 years) and CALR-mutated and TN (53 years for both) younger (p < 0.001). Female gender clustered with TN (76%) and JAK2 (67%) vs CALR (46%) mutations (p < 0.001). ExT clustered with CALR (type-2 more than type-1), TN and MPL, and leukocytosis with JAK2 mutation (p < 0.001). In multivariable analysis, risk factors for arterial thrombosis-free survival were age ≥60 years (HR 2.0; p < 0.001) and JAK2 mutation (HR 1.3; p = 0.02) with borderline significance for male gender (p = 0.08) and cardiovascular risk factors (p = 0.08); for venous thrombosis-free survival, JAK2 mutation (HR 1.9; p = 0.03) with borderline significance for venous thrombosis history (p = 0.07); for overall survival, older age (p < 0.001), male gender (HR 1.9; p < 0.001), absolute neutrophil count (ANC) ≥ 8 × 109/L (HR 1.8; p = 0.01), absolute lymphocyte count (ALC) < 1.7 × 109/L (HR 1.2; p = 0.03); for myelofibrosis-free survival, CALR mutation (HR 2.7; p < 0.001, particularly for CALR type 1/1-like, HR 3.3) and MPL mutation (HR 3.9; p = 0.001); for leukemia-free survival, older age (p = 0.03). Cytoreductive therapy appeared to mitigate both venous (HR 0.3; p = 0.01) and arterial thrombosis (HR 4; p = 0.04); there was a trend for aspirin in preventing arterial thrombosis recurrence. The current study provides real-world observations in essential thrombocythemia, representing a valid source document for interpreting current literature and planning future studies.
Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21
Authors: Sui Yue , Liu Qingqing , Xu Cong , Ganesan Kumar , Ye Zhen , Li Yan , Wu Jianmin , Du Bing , Gao Fei , Song Cailu , Chen Jianping 
Published: January 2024

AbstractNon-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer progression, but the underlying mechanisms remain unclear. In this study, we investigated the impact of NAFLD on breast cancer tumor growth and cell viability through the potential mediator, hepatic fibroblast growth factor 21 (FGF21). Both peritumoral and systemic administration of FGF21 promoted breast cancer tumor growth, while FGF21 knockout attenuated the tumor-promoting effects of the high-fat diet. Mechanistically, exogenous FGF21 treatment enhanced the anti-apoptotic ability of breast cancer cells through STAT3 and Akt/FoXO1 signaling pathways, and mitigated doxorubicin-induced cell death. Furthermore, we observed overexpression of FGF21 in tumor tissues from breast cancer patients, which was associated with poor prognosis. These findings suggest a novel role for FGF21 as an upregulated mediator in the context of NAFLD, promoting breast cancer development and highlighting its potential as a therapeutic target for cancer treatment.
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Authors: Holling G. Aaron , Chavel Colin A. , Sharda Anand P. , Lieberman Mackenzie M. , James Caitlin M. , Lightman Shivana M. , Tong Jason H. , Qiao Guanxi , Emmons Tiffany R. , Giridharan Thejaswini , Hou Shengqi , Intlekofer Andrew M. , Higashi Richard M. , Fan Teresa W. M. , Lane Andrew N. , Eng Kevin H. , Segal Brahm H. , Repasky Elizabeth A. , Lee Kelvin P. , Olejniczak Scott H. 
Published: January 2024

AbstractMetabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic flexibility of T cells have not been determined. In this study, we investigated the influence of the nuclear cap-binding complex (CBC) adaptor protein ARS2 on mature T cells. In doing so, we discovered a novel signaling axis that endows activated CD8+ T cells with flexibility of glucose catabolism. ARS2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing events. Among these effects, the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2, a key determinant of CD8+ T-cell glucose utilization, interferon gamma production, and antitumor effector function. Importantly, PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation, revealing a novel means by which costimulation reprograms glucose metabolism in CD8+ T cells.
Quantum fluctuations drive nonmonotonic correlations in a qubit lattice
Authors: Lopez-Bezanilla Alejandro , King Andrew D. , Nisoli Cristiano , Saxena Avadh 
Published: January 2024

AbstractFluctuations may induce the degradation of order by overcoming ordering interactions, consequently leading to an increase of entropy. This is particularly evident in magnetic systems characterized by nontrivial, constrained disorder, where thermal or quantum fluctuations can yield counterintuitive forms of ordering. Using the proven efficiency of quantum annealers as programmable spin system simulators, we present a study based on entropy postulates and experiments on a platform of programmable superconducting qubits to show that a low level of uncertainty can promote ordering in a system impacted by both thermal and quantum fluctuations. A set of experiments is proposed on a lattice of interacting qubits arranged in a triangular geometry with precisely controlled disorder, effective temperature, and quantum fluctuations. Our results demonstrate the creation of ordered ferrimagnetic and layered anisotropic disordered phases, displaying characteristics akin to the elegant order-by-disorder phenomenon. Extensive experimental evidence is provided for the role of quantum fluctuations in lowering the total energy of the system by increasing entropy and defect clustering. Our thorough and comprehensive application of an intentionally introduced noise on a quantum platform provides insight into the dynamics of defects and fluctuations in quantum devices, which may help to reduce the cost associated with quantum processing.
Sox9 regulates alternative splicing and pancreatic beta cell function
Authors: Puri Sapna , Maachi Hasna , Nair Gopika , Russ Holger A. , Chen Richard , Pulimeno Pamela , Cutts Zachary , Ntranos Vasilis , Hebrok Matthias 
Published: January 2024

AbstractDespite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator of pancreas development, also functions in mature beta cells. Our results show that Sox9-depleted rodent beta cells have defective insulin secretion, and aging animals develop glucose intolerance, mimicking the progressive degeneration observed in T2D. Using genome editing in human stem cells, we show that beta cells lacking SOX9 have stunted first-phase insulin secretion. In human and rodent cells, loss of Sox9 disrupts alternative splicing and triggers accumulation of non-functional isoforms of genes with key roles in beta cell function. Sox9 depletion reduces expression of protein-coding splice variants of the serine-rich splicing factor arginine SRSF5, a major splicing enhancer that regulates alternative splicing. Our data highlight the role of SOX9 as a regulator of alternative splicing in mature beta cell function.