bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alveolar Ridge Augmentation: A Comparative Longitudinal Study Between Calvaria and Iliac Crest Bone Grafts
Authors: Carinci Francesco , Farina Antonio , Zanetti Umberto , Vinci Raffaele , Negrini Stefano , Calura Giorgio , Laino Gregorio , Piattelli Adriano 
Published: February 2005

AbstractInsertion of endosseous implants is often difficult because of lack of supporting bone. In the case of severe atrophy of the jaws, a large volume of autogenous bone can be harvested from the iliac crest and calvaria. Both grafts undergo partial resorption with time, but the rate of bone loss has not been fully elucidated. The aim of this study was to evaluate the alveolar bone height gain (ABHG) obtained with iliac crest and calvaria bone grafts. Twenty-five patients had mandibular bone grafts, 32 had maxillary bone grafts, and 11 had both mandibular and maxillary bone grafts. Measures were made on preoperative, postoperative, and follow-up radiographs. A general linear model was used to evaluate the rate of ABHG plotted against months elapsed from the time of the operation to the time of follow-up. General linear model output showed a statistically significant effect for only the type of donor bone graft (P = .004), with a better ABHG for calvaria. The iliac crest bone grafts lost most of the ABHG in the first 6 months, whereas calvaria bone grafts lost ABHG over a greater interval of time. The type of bone graft is the strongest predictor of ABHG, and calvaria bone graft had a higher stability than did iliac bone graft. However, the gap in ABHG between the 2 grafts tended to decrease over time.
Bone Remodeling in Immediately Loaded and Unloaded Titanium Dental Implants: A Histologic and Histomorphometric Study in Humans
Authors: Degidi Marco , Scarano Antonio , Piattelli Maurizio , Perrotti Vittoria , Piattelli Adriano 
Published: February 2005

Abstract
Remodeling is thought to prevent microdamage accumulation caused by repetitive loading and to increase the fatigue life of bone. The bone remodeling rate (BRR) is the period of time needed for new bone to replace the existing bone and to allow for the adaptation of bone to its environment. BRR is expressed as a percentage or volume of new bone within a specific time period. The aim of the present study was to evaluate bone remodeling events on submerged and immediately loaded dental implants. Twelve patients with edentulous mandibles participated in this study. All patients were rehabilitated with fixed mandibular prostheses, with 10 dental implants per patient. An additional implant was inserted in the most distal posterior mandibular jaw region. In 6 patients, these additional implants were loaded with a fixed provisional prosthesis the same day of the implant surgery and loaded. In the other 6 patients, the additional implants were left submerged and not loaded. After 6 months, all the additional implants were retrieved with a trephine. The percentage of woven and lamellar bone, number of osteoclasts and osteoblasts, and percentage of bone labeled by tetracycline at 0.5 mm and 2 mm from the implant surface were evaluated. The percentage of lamellar bone, number of osteoblasts, and percentage of bone tetracycline labeling was significantly higher in the loaded implants than in the unloaded implants (P = .0001). Also in the loaded implants, the percentage of woven and lamellar bone, number of osteoclasts and osteoblasts, and percentage of bone tetracycline labeling was significantly higher at 0.5 mm than at 2 mm from the implant surface (P = .0001). No such differences were found in unloaded implants (P = .377). In conclusion, we found that (1) loading appeared to stimulate bone remodeling at the interface, (2) a higher percentage of lamellar bone was found in loaded implants, (3) the percentage of bone labeling was higher at the interface of loaded implants, (4) no differences were found in the BRRs between immediately loaded and unloaded implants, and (5) immediate loading had not interfered on the lamellar bone formation at the interface and had not produced formation of woven bone at the interface.
A 7-year Follow-up of 93 Immediately Loaded Titanium Dental Implants
Authors: Degidi Marco , Piattelli Adriano 
Published: February 2005

Abstract
Recently, several experimental and clinical investigations found that immediately loaded implants obtained satisfactory levels of osseointegration with high success percentages. Only a few long-term studies of immediately loaded implants have been reported in the literature. The aim of this study was a 7-year clinical and radiographic follow-up of 93 immediately loaded dental implants in human patients. Eleven patients were consecutively enrolled in this study. A total of 7 full and 9 partial edentulous arches were rehabilitated. Patients presented a completely edentulous mandible (n = 6), a completely edentulous maxilla (n = 1), mandibular posterior edentulous areas (n = 5), or a posterior maxillary edentulous area (n = 1). Patients were rehabilitated with a bar and an overdenture (n = 4), a provisional prosthesis of 3 to 12 elements (n = 11), or a metal-ceramic bridge of 10 elements (n = 1). A total of 93 implants were inserted and loaded within a 24-hour time frame. Six implants failed in the first year after loading. No more failures were observed in the following 6 years, and all the other implants were well integrated from a clinical and radiographic point of view. The cumulative success rate at 7 years was 93.5%, and the prostheses survival rate was 98.5%. The mean marginal bone loss was 0.6 mm after the first year and 1.1 mm at the 7-year evaluation. Primary stability is one of the most important parameters in immediately loaded implants because it avoids micromotion at the bone-implant interface. Four of the 6 failures in our patients occurred in partially edentulous patients; an excessive load applied to these small bridges could be the reason for the failure. Also, the bone quality is important, for 3 of our failed implants had been inserted in D3 bone. Our clinical and radiographic results have shown that these immediately loaded implants have remained osseointegrated for a long period. Our results point to the possibility of using the immediate loading technique in selected and well-informed cases.
Comparing faculty information seeking in teaching and research: Implications for the design of digital libraries
Authors: Borgman Christine L. , Smart Laura J. , Millwood Kelli A. , Finley Jason R. , Champeny Leslie , Gilliland Anne J. , Leazer Gregory H. 
Published: February 2005

AbstractADEPT is a 5‐year project whose goals are to develop, deploy, and evaluate inquiry learning capabilities for the Alexandria Digital Library, an extant digital library of primary sources in geography. We interviewed nine geography faculty members who teach undergraduate courses about their information seeking for research and teaching and their use of information resources in teaching. These data were supplemented by interviews with four faculty members from another ADEPT study about the nature of knowledge in geography. Among our key findings are that geography faculty are more likely to encounter useful teaching resources while seeking research resources than vice versa, although the influence goes in both directions. Their greatest information needs are for research data, maps, and images. They desire better searching by concept or theme, in addition to searching by location and place name. They make extensive use of their own research resources in their teaching. Among the implications for functionality and architecture of geographic digital libraries for educational use are that personal digital libraries are essential, because individual faculty members have personalized approaches to selecting, collecting, and organizing teaching resources. Digital library services for research and teaching should include the ability to import content from common office software and to store content in standard formats that can be exported to other applications. Digital library services can facilitate sharing among faculty but cannot overcome barriers such as intellectual property rights, access to proprietary research data, or the desire of individuals to maintain control over their own resources. Faculty use of primary and secondary resources needs to be better understood if we are to design successful digital libraries for research and teaching.
parva germina, a gene involved in germ cell maintenance during male and female Drosophila gametogenesis
Authors: Riparbelli Maria Giovanna , Inoue Yoshihiro , Glover David M. , Callaini Giuliano 
Published: February 2005

AbstractWe report the initial characterization of a gene, parva germina (pag), required for germ cell maintenance in both males and females. pag gonads contain a small number of germline stem cells at the onset of gametogenesis. In contrast, adult mutant gonads are either empty or have a very small number of germ cells that never develop in 16‐cell cysts. Ovarioles and testes, therefore, are rudimentary, and the very few germ cells they contain are unable to differentiate into eggs or sperm. Germline stem cells are progressively depleted over time. The average number of germ cells, therefore, decreases in pag mutant ovarioles with the age of the mother, whereas the proportion of agametic germaria goes up. These observations suggest that the pag gene product is involved in germ cell maintenance in both male and female gametogenesis. Developmental Dynamics 232:835–844, 2005. © 2005 Wiley‐Liss, Inc.
Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development
Authors: Sotillos Sol , De Celis Jose F. 
Published: February 2005

AbstractThe formation of longitudinal veins in the Drosophila wing involves cell interactions mediated by the conserved signaling pathways Decapentaplegic (Dpp), Notch, and epidermal growth factor receptor (EGFR). Interactions between Notch and EGFR taking place in the wing disc divide each vein into a central domain, where EGFR is active, and two boundary domains where Notch is active. The expression of decapentaplegic (dpp) is activated in the veins during pupal development, and we have generated Gal4 drivers using the regulatory region that drives dpp expression at this stage. By using these drivers, we studied the relationships between the Notch, EGFR, and Dpp signaling pathways that occur during pupal development. Our results indicate that the interactions between EGFR and Notch initiated in the imaginal disc are maintained throughout pupal development and contribute to determine the places where dpp is expressed. Once dpp expression is initiated, Dpp and EGFR activities in the provein maintain each other and, in cooperation, determine vein cell differentiation. Developmental Dynamics 232:738–752, 2005. © 2005 Wiley‐Liss, Inc.
L1 augments cell migration and tumor growth but not β3 integrin expression in ovarian carcinomas
Authors: Gast Daniela , Riedle Svenja , Riedle Svenja , Schabath Heidi , Schlich Sabine , Schneider Annette , Issa Yasmin , Stoeck Alexander , Fogel Mina , Joumaa Safwan , Wenger Till , Herr Ingrid , Gutwein Paul , Altevogt Peter 
Published: February 2005

AbstractL1 is a neural cell adhesion molecule involved in cell migration, axon growth and guidance. Recent data have shown that L1 is overexpressed in ovarian and endometrial tumors and is associated with bad prognosis. How L1 promotes tumor progression is presently unknown. Here we show that L1 expression is predominantly confined to the invasive front of ovarian carcinomas. Overexpression of L1 in carcinoma cell lines by adenovirus‐mediated gene transfer enhanced the haptotactic cell migration on extracellular matrix proteins. Expression of L1 augmented tumor growth of carcinomas xenografted in nonobese diabetic/severe combined immunodeficient mice (NOD/SCID). A recent report has demonstrated L1‐dependent upregulation of β3 integrin involving activation of the extracellular signal‐regulated kinase (erk) pathway. We find that L1 and β3 integrin are not coexpressed in ovarian carcinoma tissues. Overexpression of L1 did not upregulate β3 integrin in ovarian carcinoma cell lines but could do so in HEK293 cells. Our results suggest that L1 could drive progression by enhancing cell migration and tumor growth but that L1 dependent and erk‐regulated gene expression requires cell‐type specific elements. © 2005 Wiley‐Liss, Inc.
IL1RN polymorphic gene and cagA‐positive status independently increase the risk of noncardia gastric carcinoma
Authors: Rocha Gifone Aguiar , Guerra Juliana Becattini , Rocha Andreia Maria Camargos , Saraiva Ivan Euclides Borges , da Silva Deborah Alves , de Oliveira Celso Affonso , Queiroz Dulciene Maria Magalhães 
Published: February 2005

AbstractHelicobacter pylori cagA‐positive strains and host cytokine proinflammatory polymorphisms have been associated with gastric carcinoma. However, the individual role of each factor has not been evaluated yet. Our aim was to evaluate whether IL‐1 gene cluster and tumor necrosis factor‐α (TNFA)‐307 polymorphisms, as well as cagA‐positive status, are associated with gastric carcinoma in a non‐Caucasian population by analyzing the data in logistic regression models. We evaluated 166 patients with noncardia gastric carcinoma and 541 blood donors. Among them, 702 were successfully genotyped for all cytokine studied: 166 with gastric carcinoma and 536 controls. The carcinoma patients were considered to be H. pylori‐positive if culture alone or 2 among preformed urease test, stained smear or histologic section, serology, polymerase chain reaction (PCR) for ureA and urea breath test were positive. In blood donors, H. pylori status was based on enzyme‐linked immunosorbent assay. The cagA status was determined by PCR or serology. IL1B‐511/‐31, IL1RN (interleukin‐1 receptor antagonist) and TNFA‐307 polymorphisms were genotyped by PCR, PCR with restriction fragment length polymorphism, or PCR with confronting 2‐pair primers. We found that the IL1RN2 polymorphic allele (OR = 1.93) was associated with noncardia gastric carcinoma, even after inclusion of age, gender and cagA status in the logistic models. However, the cagA‐positive status was the strongest independent factor associated with gastric carcinoma (OR = 11.89). The other polymorphisms were not significantly associated with the disease when they were evaluated in logistic models. This study provides evidence supporting the independent associations of cagA‐positive H. pylori status and IL1RN polymorphisms with noncardia gastric carcinoma. © 2005 Wiley‐Liss, Inc.
Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas
Authors: Körner Meike , Waser Beatrice , Reubi Jean Claude 
Published: February 2005

AbstractNumerous peptide receptors are overexpressed in human cancer, permitting in vivo tumor targeting. Among such receptors, those for the neurotransmitter neuropeptide Y (NPY) are overexpressed in various tumors. Since NPY can play a role in the kidney, NPY receptor expression and/or endogenous production of peptides of the NPY family (NPY, PYY, PP) were evaluated in 40 renal cell carcinomas (RCCs) and 18 nephroblastomas. NPY receptor protein expression was investigated by in vitro autoradiography using 125I‐labeled PYY in competition with NPY receptor subtype‐selective analogs. NPY, PYY and PP production was assessed immunohistochemically. Fifty‐six percent of RCCs expressed the Y1 receptor subtype in moderate density, and 80% of nephroblastomas expressed Y1 and Y2 subtypes in moderate to high density. Y1 was also highly expressed in intratumoral blood vessels. In selected cases, NPY was observed in nerve fibers in close association with intratumoral blood vessels and in the vicinity of tumor cells, while no PYY or PP was detected immunohistochemically in these sites. NPY receptors on renal tumor cells and tumor blood vessels may therefore be the molecular targets of endogenous NPY released by intratumoral nerve fibers. With regard to clinical applications, NPY receptors may act as in vivo targets for receptor‐directed therapy of RCCs and nephroblastomas for which alternative therapeutic approaches are still required. © 2005 Wiley‐Liss, Inc.
D. Liu and X. Zhu, Erratum to: “Fractional chromatic number and circular chromatic number for distance graphs with large clique size”. Journal of Graph Theory47(2) 2004, 129–146
Authors: Liu Daphne Der‐Fen , Zhu Xuding 
Published: February 2005

AbstractThe original article to which this Erratum refers was published in Journal of Graph Theory 47:129–146,2004.
The efficiency of laser for the treatment of Ehlers–Danlos syndrome
Authors: Mueller Daniel F. , Zimmermann Alexander , Borelli Claudia 
Published: February 2005

AbstractBackground and ObjectivesA 61‐year‐old woman presented herself with extensive elastosis of the facial skin caused by Ehlers–Danlos syndrome (EDS).Study Design/Materials and MethodsTwo laser skin resurfacings reduced the wrinkles significantly better than the two preceding conventional facelifts. For the first time, we have been able to compare two treatments with different laser systems on the same patient. The first treatment was performed with a high energy pulsed CO2 laser, which has been in use for 8 years. The second treatment was performed by us using the latest technology CO2/erbium:YAG combination laser.Results/ConclusionResulting in a similar degree of wrinkle reduction, the treatment with the combination laser markedly reduced the duration of the healing process and erythema phase. Lasers Surg. Med. 36:76–78, 2005. © 2005 Wiley‐Liss, Inc.
Long‐term in vivo stability of rabbit nasal septal cartilage following laser cartilage reshaping: A pilot investigation
Authors: Karamzadeh Amir M. , Chang John C. , Diaz Sergio , Milner Thomas E. , Wong Brian J.F. 
Published: February 2005

AbstractBackground and ObjectivesTo evaluate the long‐term effect of laser cartilage reshaping on rabbit nasal septal cartilage viability and mechanical integrity in an in vivo model.Study Design/Materials and MethodsIn vivo animal investigation. Rabbit septal cartilage specimens were laser (Nd:YAG, λ = 1.32 μm, spot size 5.4‐mm diameter, 10 W, 10 seconds, 50 Hz PPR) reshaped and subsequently reimplanted into an interscapular subcutaneous pocket. Specimens were harvested at 8 and 12 months and evaluated using photography, flow cytometry, and histology.ResultsGrossly, specimens showed alteration in the physical integrity with varying degrees of tissue resorption. The non‐irradiated control specimens demonstrated significantly increased stiffness. Histologically, there was marked depletion of the extracellular matrix and an overall reduction in tissue mass in laser irradiated tissues. However, flow cytometry data identified viable chondrocytes in laser‐irradiated specimens that were identical to those observed in controls.ConclusionsStudy results demonstrate that the rabbit nasal septal cartilage model can be effectively used to study laser reshaping, however alternative recipient sites with perichondrial lining, such as the pinna, may provide a more realistic physiologic environment for reshaped graft tissue. The dosimetry used in this pilot study likely led to significant thermal injury. Study results underscore the importance of elucidating the optimal laser dosimetry required to initiate permanent shape change while minimizing thermal damage. Lasers Surg. Med. 36:147–154, 2005. © 2005 Wiley‐Liss, Inc.
Laser treatment of leg veins: Physical mechanisms and theoretical considerations
Authors: Ross Edward Victor , Domankevitz Yacov 
Published: February 2005

AbstractBackground and ObjectivesA discussion of laser treatment of leg veins is based on a review of the literature, theoretical analysis, and the clinical experiences of the authors. Theoretical computations are discussed within the context of clinical observations.Study Design/Materials and MethodsA Monte Carlo model is used to examine volumetric heat production, fluence rate, and temperature profiles in blood vessels at 1,064 and 532 nm wavelengths with various beam diameters, vessel diameters, and pulse durations.ResultsClinical observations, Monte Carlo results, and a review of the literature suggest that longer wavelengths and longer pulses durations favor vessel contraction over intraluminal thrombosis. Monte Carlo simulations show that longer wavelengths are more likely to uniformly heat the vessel compared to highly absorbing wavelengths. Methemoglobin production causes deeply penetrating wavelengths to generate more volumetric heat for the same input radiant exposure.ConclusionsClinical observations and models support the role of long wavelengths and long pulses in optimal clearance of most leg telangiectasias. Lasers Surg. Med. 36:105–116, 2005. © 2005 Wiley‐Liss, Inc.
Effects of hypobaric pressure on human skin: Implications for cryogen spray cooling (Part II)
Authors: Aguilar Guillermo , Franco Walfre , Liu Jie , Svaasand Lars O. , Nelson J. Stuart 
Published: February 2005

AbstractBackground and ObjectivesClinical results have demonstrated that dark purple port wine stain (PWS) birthmarks respond favorably to laser induced photothermolysis after the first three to five treatments. Nevertheless, complete blanching is rarely achieved and the lesions stabilize at a red‐pink color. In a feasibility study (Part I), we showed that local hypobaric pressure on PWS human skin prior to laser irradiation induced significant lesion blanching. The objective of the present study (Part II) is to investigate the effects of hypobaric pressures on the efficiency of cryogen spray cooling (CSC), a technique that assists laser therapy of PWS and other dermatoses.Study Design/Materials and MethodsExperiments were carried out within a suction cup and vacuum chamber to study the effect of hypobaric pressure on the: (1) interaction of cryogen sprays with human skin; (2) spray atomization; and (3) thermal response of a model skin phantom. A high‐speed camera was used to acquire digital images of spray impingement on in vivo human skin and spray cones generated at different hypobaric pressures. Subsequently, liquid cryogen was sprayed onto a skin phantom at atmospheric and 17, 34, 51, and 68 kPa (5, 10, 15, and 20 in Hg) hypobaric pressures. A fast‐response temperature sensor measured sub‐surface phantom temperature as a function of time. Measurements were used to solve an inverse heat conduction problem to calculate surface temperatures, heat flux, and overall heat extraction at the skin phantom surface.ResultsUnder hypobaric pressures, cryogen spurts did not produce skin indentation and only minimal frost formation. Sprays also showed shorter jet lengths and better atomization. Lower minimum surface temperatures and higher overall heat extraction from skin phantoms were reached.ConclusionsThe combined effects of hypobaric pressure result in more efficient cryogen evaporation that enhances heat extraction and, therefore, improves the epidermal protection provided by CSC. Lasers Surg. Med. 36:130–135, 2005. © 2005 Wiley‐Liss, Inc.
Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: First case report
Authors: Suzuki Masahiko , Hattori Nobutaka , Orimo Satoshi , Fukumitsu Nobuyoshi , Abo Masahiro , Kono Yu , Sengoku Renpei , Kurita Akira , Honda Hidehiko , Inoue Kiyoharu 
Published: February 2005

AbstractA decrease in myocardial uptake of iodine‐123–labeled metaiodobenzylguanidine (123I‐MIBG) has been reported in idiopathic Parkinson's disease (PD) using 123I‐MIBG myocardial scintigraphy. However, the patient with autosomal recessive juvenile parkinsonism (AR‐JP), caused by the parkin gene, presented here showed normal 123I‐MIBG myocardial uptake, suggesting that AR‐JP is a distinct disease entity from PD. Although the clinical features of AR‐JP are sometimes quite similar to those of late‐onset idiopathic PD, 123I‐MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR‐JP. © 2005 Movement Disorder Society