bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
Authors: Wassmann Barbara , Pfeifer Heike , Stadler Michael , Bornhaüser Martin , Bug Gesine , Scheuring Urban J. , Brück Patrick , Stelljes Matthias , Schwerdtfeger Rainer , Basara Nadezda , Perz Jolanta , Bunjes Donald , Ledderose Georg , Mahlberg Rolf , Binckebanck Anja , Gschaidmeier Harald , Hoelzer Dieter , Ottmann Oliver G. 
Published: April 2005

Abstract
In adult Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL), minimal residual disease (MRD) after stem cell transplantation (SCT) is associated with a relapse probability exceeding 90%. Starting imatinib in the setting of MRD may decrease this high relapse rate. In this prospective multicenter study, 27 Ph+ ALL patients received imatinib upon detection of MRD after SCT. Bcr-abl transcripts became undetectable in 14 (52%) of 27 patients, after a median of 1.5 months (0.9-3.7 months) (earlyCRmol). All patients who achieved an earlyCRmol remained in remission for the duration of imatinib treatment; 3 patients relapsed after imatinib was discontinued. Failure to achieve polymerase chain reaction (PCR) negativity shortly after starting imatinib predicted relapse, which occurred in 12 (92%) of 13 patients after a median of 3 months. Disease-free survival (DFS) in earlyCRmol patients is 91% ± 9% and 54% ± 21% after 12 and 24 months, respectively, compared with 8% ± 7% after 12 months in patients remaining MRD+ (P &lt; .001). In conclusion, approximately half of patients with Ph+ ALL receiving imatinib for MRD positivity after SCT experience prolonged DFS, which can be anticipated by the rapid achievement of a molecular complete remission (CR). Continued detection of bcr-abl transcripts after 2 to 3 months on imatinib identifies patients who will ultimately experience relapse and in whom additional or alternative antileukemic treatment should be initiated.
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
Authors: Lee Na Kyung , Choi Young Geum , Baik Ji Youn , Han Song Yi , Jeong Dae-won , Bae Yun Soo , Kim Nacksung , Lee Soo Young 
Published: April 2005

Abstract
Signaling by receptor activator of NF-κB (nuclear factor-κB) ligand (RANKL) is essential for differentiation of bone marrow monocyte-macrophage lineage (BMM) cells into osteoclasts. Here, we show RANKL stimulation of BMM cells transiently increased the intracellular level of reactive oxygen species (ROS) through a signaling cascade involving TNF (tumor necrosis factor) receptor-associated factor (TRAF) 6, Rac1, and NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (Nox) 1. A deficiency in TRAF6 or expression of a dominant-interfering mutant of TRAF6 blocks RANKL-mediated ROS production. Application of N-acetylcysteine (NAC) or blocking the activity of Nox, a protein leading to the formation of ROS, with diphenylene iodonium (DPI) inhibits the responses of BMM cells to RANKL, including ROS production, activation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein (MAP) kinase, and extracellular signal-regulated kinase (ERK), and osteoclast differentiation. Moreover, both RANKL-mediated ROS production and osteoclast differentiation were completely blocked in precursors depleted of Nox1 activity by RNA interference or by expressing a dominant-negative mutant of Rac1. Together, these results indicate that ROSs act as an intracellular signal mediator for osteoclast differentiation.
The Blood Pressure "Uncertainty Range" – a pragmatic approach to overcome current diagnostic uncertainties (II)
Authors: Pater Cornel 
Published: April 2005

Abstract
A tremendous amount of scientific evidence regarding the physiology and physiopathology of high blood pressure combined with a sophisticated therapeutic arsenal is at the disposal of the medical community to counteract the overall public health burden of hypertension. Ample evidence has also been gathered from a multitude of large-scale randomized trials indicating the beneficial effects of current treatment strategies in terms of reduced hypertension-related morbidity and mortality.
In spite of these impressive advances and, deeply disappointingly from a public health perspective, the real picture of hypertension management is overshadowed by widespread diagnostic inaccuracies (underdiagnosis, overdiagnosis) as well as by treatment failures generated by undertreatment, overtreatment, and misuse of medications.
The scientific, medical and patient communities as well as decision-makers worldwide are striving for greatest possible health gains from available resources.
A seemingly well-crystallised reasoning is that comprehensive strategic approaches must not only target hypertension as a pathological entity, but rather, take into account the wider environment in which hypertension is a major risk factor for cardiovascular disease carrying a great deal of our inheritance, and its interplay in the constellation of other, well-known, modifiable risk factors, i.e., attention is to be switched from one's "blood pressure level" to one's absolute cardiovascular risk and its determinants. Likewise, a risk/benefit assessment in each individual case is required in order to achieve best possible results.
Nevertheless, it is of paramount importance to insure generalizability of ABPM use in clinical practice with the aim of improving the accuracy of a first diagnosis for both individual treatment and clinical research purposes. Widespread adoption of the method requires quick adjustment of current guidelines, development of appropriate technology infrastructure and training of staff (i.e., education, decision support, and information systems for practitioners and patients). Progress can be achieved in a few years, or in the next 25 years.
Risk factors for fatal candidemia caused by Candida albicans and non-albicans Candida species
Authors: Cheng Ming-Fang , Yang Yun-Liang , Yao Tzy-Jyun , Lin Chin-Yu , Liu Jih-Shin , Tang Ran-Bin , Yu Kwok-Woon , Fan Yu-Hua , Hsieh Kai-Sheng , Ho Monto , Lo Hsiu-Jung 
Published: April 2005

Abstract

Background
Invasive fungal infections, such as candidemia, caused by Candida species have been increasing. Candidemia is not only associated with a high mortality (30% to 40%) but also extends the length of hospital stay and increases the costs of medical care. Sepsis caused by Candida species is clinically indistinguishable from bacterial infections. Although, the clinical presentations of the patients with candidemia caused by Candida albicans and non-albicans Candida species (NAC) are indistinguishable, the susceptibilities to antifungal agents of these species are different. In this study, we attempted to identify the risk factors for candidemia caused by C. albicans and NAC in the hope that this may guide initial empiric therapy.

Methods
A retrospective chart review was conducted during 1996 to 1999 at the Veterans General Hospital-Taipei.

Results
There were 130 fatal cases of candidemia, including 68 patients with C. albicans and 62 with NAC. Candidemia was the most likely cause of death in 55 of the 130 patients (42.3 %). There was no significant difference in the distribution of Candida species between those died of candidemia and those died of underlying conditions. Patients who had one of the following conditions were more likely to have C. albicans, age ≧ 65 years, immunosuppression accounted to prior use of steroids, leukocytosis, in the intensive care unit (ICU), and intravascular and urinary catheters. Patients who had undergone cancer chemotherapy often appeared less critically ill and were more likely to have NAC.

Conclusion
Clinical and epidemiological differences in the risk factors between candidemia caused by C. albicans and NAC may provide helpful clues to initiate empiric therapy for patients infected with C. albicans versus NAC.
First Dominique Dormont international conference on "Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections"
Authors: Menu Elisabeth , Müller-Trutwin Mickaela C , Pancino Gianfranco , Saez-Cirion Asier , Bain Christine , Inchauspé Geneviève , Gras Gabriel S , Mabondzo Aloïse M , Samri Assia , Boutboul Françoise , Grand Roger Le 
Published: April 2005

Abstract
The first Dominique Dormont International Conference on "Viral and host determinantsof HCV, HCMV, and HIV infections "was held in Paris, Val-de-Grâce, on December 3–4, 2004. The following is a summary of the scientific sessions of this meeting (http://www.congres-evenement.fr/ddormont).
Single Cell Array of Biotinylated Cells Using Surface Functionalization and Microcontact Printing
Authors: Lee Zee-Won , Lee Kyung-Bok , Hong Jang-Hee , Kim Jae-Hong , Choi Inpyo , Choi Insung S 
Published: April 2005

Abstract
This paper describes a versatile method for generating single cell arrays on a glass substrate, which could be applicable to any arbitrary cell types, by a combination of surface functionalization, biotinylation of cells, and microcontact printing (μCP).
Models for Iterative Multiattribute Procurement Auctions
Authors: Parkes David C. , Kalagnanam Jayant 
Published: April 2005

Multiattribute auctions extend traditional auction settings to allow negotiation over nonprice attributes such as weight, color, and terms of delivery, in addition to price and promise to improve market efficiency in markets with configurable goods. This paper provides an iterative auction design for an important special case of the multiattribute allocation problem with special (preferential independent) additive structure on the buyer value and seller costs. Auction Additive&Discrete provides a refined design for a price-based auction in which the price feedback decomposes to an additive part with a price for each attribute and an aggregate part that appears as a price discount for each supplier. In addition, this design also has excellent information revelation properties that are validated through computational experiments. The auction terminates with an outcome of a modified Vickrey-Clarke-Groves mechanism. This paper also develops Auction NonLinear&Discrete for the more general nonlinear case—a particularly simple design that solves the general multiattribute allocation problem, but requires that the auctioneer maintains prices on bundles of attribute levels.
WiKo – Eine integrierte Wissens- und Kooperations-Plattform (WiKo – An Integrated Knowledge and Cooperation Platform)
Authors: Fuchs-Kittowski Frank , Faust Daniel , Loroff Claudia , Reuter Patrick 
Published: April 2005

Zusammenfassung
Zur Unterstützung von Wissensarbeitern wird eine innovative Wissens- und Kooperations-Plattform (WiKo) für ein interaktionsorientiertes Wissensmanagement vorgestellt. Diese verbindet die Wissensbereitstellung und die Wissenserzeugung zu einem zyklischen Prozess, so dass einerseits das Wissen der Organisation durch den einzelnen Wissensarbeiter genutzt und andererseits darauf aufbauend neues Wissen in einem sozialen, kooperativen Prozess erzeugt werden kann, welches wiederum für die Organisation, die Gruppe und den Einzelnen verfügbar wird. Es wurde eine Web-basierte Plattform konzipiert, implementiert und exemplarisch erprobt, die einerseits Softwarebausteine für die verschiedenen Strategien des Wissensmanagements zur Wissensbereitstellung und -bewahrung sowie andererseits Werkzeuge für verschiedene Formen kooperativer Wissenserzeugung integriert und diese miteinander verbindet.
ContextDrive – Individuelles Informationsmanagement für das Ubiquitous Computing (ContextDrive – Personal Information Management for Ubiquitous Computing)
Authors: Prante Thorsten , Petrovic Kostanija , Stenzel Richard 
Published: April 2005

Zusammenfassung
In diesem Beitrag wird das ContextDrive vorgestellt, ein kontext-bewusstes System, das Benutzer in Ubiquitous-Computing Umgebungen beim Rückgriff auf Informationen im Rahmen der Wiederaufnahme von Aufgaben oder allgemein bei der Wiederbenutzung von Informationen unterstützt. Dazu wird werkzeug- und geräteübergreifend hybrider Nutzungskontext protokolliert. Die so aufgebaute Kontexthistorie ist die Basis für den zusammenführenden Rückgriff auf zuvor benutzte Informationen. Dies wird anhand einer zeitorientierten Benutzungsoberfläche und mit Aufgabenkarten exemplarisch gezeigt. Bei dem vorliegenden Artikel handelt es sich um eine aktualisierte und erweiterte Version des Beitrags auf der Mensch-und-Computer-Tagung 2004, der den zweiten Platz im Wettbewerb um den Best-Paper-Award erzielen konnte.
The Extension of the Stability Range of the Reconstructed Au(111) Surface by Propanal
Authors: Skołuda Piotr 
Published: April 2005

Abstract
The impact of propanal on the stability range of the reconstructed Au(111) surface has been investigated by cyclic voltammetry and capacity measurements. The results show that propanal extends the stability of the Au(111) in a larger range than that of Au(100) surface.
Theoretical Study of the Electronically Excited States of B4, B4
+ and B4
−
Authors: Gillery Claire , Linguerri Roberto , Rosmus Pavel , Maier John P. 
Published: April 2005

Abstract
First-principle full valence complete active space calculations (CASSCF) are reported for the electronic states of the D2

h
and C2

v
planar isomers of B4, B4
+ and B4
−. This approach is found to reproduce well the experimentally known transition energies for the two lowest excited triplet states of the most stable rhombic B4 isomer. The pattern of electronic transitions up to about 4.5 eV for B4 singlet and B4
+ doublet states calculated in similar way should guide an UV spectroscopic search.
High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma
Authors: Lo Chung-Yau , Lam Kin-Yin , Leung Pauline P , Luk John M 
Published: April 2005

Background: Cyclooxygenase-2 (COX-2) seems to play a role in the development and carcinogenesis of papillary thyroid carcinoma. Its incidence of expression and potential application as a tumor marker remain to be elucidated.
Materials and methods: Immunohistochemical staining for COX-2 expression was performed for 30 papillary thyroid carcinoma (PTC) and 40 benign thyroid specimens. COX-2 mRNA expression was analyzed using a reverse transcriptase-polymerase chain reaction (RT-PCR) for paired fresh frozen tissues removed from surgically resected PTC specimens.
Results: COX-2 expression was detected by immunohistochemistry in 27 of 30 (90%) PTC but was absent in 40 benign thyroid specimens, including 27 nodular hyperplasia, 7 follicular adenoma and 6 lymphocytic thyroiditis. Two of the three COX-2 negative carcinomas were follicular variant of PTC. RT-PCR analysis confirmed COX-2 mRNA over-expression in 14 of 20 (70%) paired specimens of PTC. Real-time quantitative RT-PCR showed that the level of COX-2 mRNA expression was significantly higher in PTC than in both the adjacent non-cancerous tissues and the benign thyroid specimens.
Conclusion: COX-2 is frequently expressed in PTC but not in benign thyroid specimens. COX-2 expression may serve as a useful molecular marker for PTC in cases of diagnostic difficulty.
Tools for Visualizing Multidimensional Images from Living Specimens
Authors: Eliceiri Kevin W. , Rueden Curtis 
Published: April 2005

ABSTRACTOver the last 50 years modern cell biology has been driven by the development of powerful imaging techniques. In particular, new developments in light microscopy that provide the potential to image the dynamics of biological events have had significant impact. Optical sectioning techniques allow three‐dimensional information to be obtained from living specimens noninvasively. When used with multimodal fluorescence microscopy, advanced optical sectioning techniques provide multidimensional image data that can reveal information not only about the changing cytoarchitecture of a cell but also about its physiology. These additional dimensions of information, although providing powerful tools, also pose significant visualization challenges to the investigator. Particularly in the current postgenomic era there is a greater need than ever for the development of effective tools for image visualization and management. In this review we discuss the visualization challenges presented by multidimensional imaging and describe three open‐source software programs being developed to help address these challenges: Image J, the Open Microscopy Environment, and VisBio.
Structure and Mechanism of Monoamine Oxidase
Authors: Edmondson D. E. , Mattevi A. , Binda C. , Li M. , Hubálek F. 
Published: April 2005

Abstract

Monoamine oxidases A and B (MAO A and MAO B) are mitochondrial outer membrane‐bound flavoproteins that catalyze the oxidative deamination of neurotransmitters and biogenic amines. A number of mechanism‐based inhibitors (MAOIs) have been developed for clinical use as antidepressants and as neuroprotective drugs. To facilitate the development of more effective and specific inhibitors, a detailed understanding of the structures and catalytic mechanisms of these enzymes is required. The recent development of high level expression systems for producing recombinant human liver MAO A and MAO B in
Pichia pastoris
has facilitated the determination of the three‐dimensional crystal structures of MAO B (up to 1.7 Å resolution) in complex with different reversible (isatin, 1,4‐diphenyl‐2‐butene) and irreversible inhibitors (pargyline,
N
‐(2‐aminoethyl)‐
p
‐chlorobenzamide, and
trans
‐2‐phenylcyclopropylamine). The binding of substrates or inhibitors to MAO B involves an initial negotiation of a protein loop occurring near the surface of the membrane and two hydrophobic cavities; an “entrance” cavity and an “active site” cavity. These two cavities can either be separate or in a fused state depending on the conformation of the Ile199 side chain, which appears to function as a gate. The amine function of the bound substrate approaches the
re
face of the bent and “puckered” covalent FAD through an “aromatic cage” formed by two tyrosine residues that are perpendicular to the plane of the flavin ring. No amino acid residues that could function as acids or bases are found near the catalytic site. The existing structural data on MAO B support previous QSAR results and are also supportive of a proposed polar nucleophilic mechanism for MAO A and B catalysis rather than the alternatively proposed single electron transfer (SET) mechanism.
Irrigation in the
U
nited
S
tates
Authors: Lasserre Frederic 
Published: April 2005

Abstract
The total amount of farmland, comprising both cropland and pastureland, is slowly decreasing in the United States at 71.2 million hectares (M ha) (176 million acres) in 1998, but irrigated lands kept increasing from 16.7 Mha in 1974, 19.8 Mha in 1982, 19.9 Mha in 1992, and 25 Mha in 2000. The geography of the increase in irrigated lands is contrasted. The national yearly increase for the period 1974–2000 is 1.57%, but east central and Atlantic states witnessed much stronger growth, well above 4%, on average, whereas Arizona, Montana, Nevada, Texas, Oklahoma, and Wyoming saw their irrigated lands shrink overall.
Microbial Quality of Reclaimed Irrigation: International Perspective
Authors: Alum Absar 
Published: April 2005

Abstract
Wastewater reuse has been practiced in different forms throughout the history of human civilization. Previously, sewage had been dumped in rivers and lakes or used locally to irrigate crops. Explosive population growth and diminishing fresh water resources around the globe have now made wastewater a valuable resource, especially in arid and semiarid areas of the world. The introduction of modern wastewater treatment processes has given new dimensions to water reuse. Reclaimed waters are commonly used for landscape or recreational irrigation (parks, golf courses, athletic fields, school yards, highway medians, and public and private lands) and agricultural crop irrigation (field crops, vegetables, orchids, and tree plantations).
Human feces, which may have microbial constituents as high as 10–30%, are one of the major sources of infectious and noninfectious agents found in municipal wastewater. Thus, wastewater can contain high concentrations of excreta‐related microorganisms. The principal microorganisms (infectious agents) that may be present in raw sewage can be classified into three broad groups: bacteria, parasites (protozoa and helminths), and viruses. During an outbreak, pathogen numbers in local sewage go up. More than 30 excreta‐related diseases of public health importance have been documented, and many of these are of specific importance in wastewater reuse schemes. Table 1 summarizes the major infectious agents potentially present in raw domestic wastewater and their respective diseases.
Microirrigation: An Approach to Efficient Irrigation
Authors: Chauhan Harenda Singh 
Published: April 2005

Abstract
Microirrigation, earlier known as Drip or Trickle irrigation is a highly efficient method of water application. It developed and expanded globally at a fast rate in the last two decades in more than 35 countries with maximum coverage in the United States. This is most appropriately applicable to widely spaced crops such as fruits, vegetables and field crops. Its different variations consist of surface trickle, bubbler, microsprinkler, spray, mechanical move, pulse, subsurface drip, all of which are covered under a single term microirrigation. In the present article, its advantages, components, system design, fertigation, automation and other aspects has been described. Also the extent of application to different crops, and in different countries, limitations, scope, research trends and strategies of promotion has been discussed.
Remediation of Pesticide‐Contaminated Soil at Agrichemical Facilities
Authors: Roy William R. 
Published: April 2005

AbstractThe remediation of contaminated soil also requires establishing some type of cleanup goals or objectives. Such objectives are used to determine whether the soil is “contaminated” in a regulatory context. Depending on the specific type, agrichemicals are subject to various physicochemical and biological processes that can reduce their concentrations in soil and groundwater. Unlike other common contaminants such as chlorinated hydrocarbons, agrichemicals areintentionallyreleased into the environment to promote plant growth and to limit the spread of weeds. A mixture of application‐rate equivalents and risk‐based processes to derive soil cleanup objectives have been promulgated in the Midwest. For example, the Illinois Department of Agriculture provides a default soil‐cleanup objective (SCO) for surface soil (0 to 12 inches) and subsurface soil (12 to 60 inches) for each major pesticide used in Illinois. A facility also has the option of developing site‐specific SCOs. These SCOs were derived from the application of soil screening levels (SSLs) developed by the U.S. Environmental Protection Agency. The resulting SCOs take into account the movement and chemical fate of a given chemical in soil–water systems. In the application of the SSL concepts, three physicochemical‐fate mechanisms are considered: dilution in groundwater, adsorption by soil organic matter, and volatilization. Degradation by biotic or abiotic mechanisms is not considered.