bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating inflammatory cytokines and psoriasis risk: A systematic review and meta-analysis
Authors: Liu Xiao-Qing , Zhou Pei-Lin , Yin Xin-Yu , Wang Ai-Xue , Wang Da-Hu , Yang Yun , Liu Qiang 
Published: October 2023

Background
Psoriasis is a systemic immune-mediated chronic inflammatory skin disease; its systemic manifestations and periodic recurrence negatively affect a patient’s quality of life. Inflammatory cytokines are known to have an important role in the onset and progression of psoriasis, however, data on the association between circulating inflammatory cytokines and psoriasis risk is inconclusive. Here, we explore the relevance of circulating proinflammatory factors to the pathogenesis of psoriasis using a meta-analysis.

Objective
To explore the association between circulating levels of inflammatory factors and psoriasis to elucidate the mechanisms underlying psoriasis and improve clinical diagnosis and treatment.

Methods
We systematically retrieved articles published in PubMed, EMBASE, the Cochrane Library and the Web of Science from the establishment of each database to January 2023. The standard mean difference (SMD) in cytokine levels of individuals with psoriasis and healthy controls was used to check for correlations between circulating inflammatory factor levels and psoriasis.

Results
Fifty-seven studies, with data from 2838 patients, were retrieved and included in the meta-analysis. Eleven inflammatory factors were studied (circulating interleukin-2 (IL-2), IL-4, IL-12, IL-17, IL-18, IL-22, IL-23, IL-35, IL-36, transforming growth factor-beta (TGF-β) and gamma-interferon (IFN-γ)). Of these, IL-2 [SMD = 1.29 (95% CI: 0.61–1.97; P <0.001)], IL-17 [SMD = 0.71 (95% CI: 0.12–1.30; P = 0.018)], IL-18 [SMD = 1.27 (95% CI: 0.64–1.90; P <0.001)], and IFN-γ [SMD = 1.90 (95% CI: 1.27–2.52; P <0.001)] levels had significant correlations with psoriasis.

Conclusion
Increased serum concentrations of the circulating inflammatory cytokines IL-2, IL-17, IL-18 and IFN-γ were significantly correlated with psoriasis.
Health-related quality of life and its associated factors in patients with chronic obstructive pulmonary disease
Authors: Jarab Anan S. , Al-Qerem Walid , Alzoubi Karem H. , Abu Heshmeh Shrouq , Mukattash Tareq L. , Naser Abdallah Y. , Al Hamarneh Yazid N. 
Published: October 2023

ObjectiveThe present study aimed to evaluate HRQOL and to explore the factors associated with poor HRQOL among patients with COPD.MethodsIn the present cross-sectional study, the validatedSt George’s Respiratory Questionnaire for COPD patients(SGRQ-C) was used to evaluate HRQOL among 702 patients with COPD at two major hospitals in Jordan in the period between January and April 2022. Quantile regression analysis was used to explore the factors associated with HRQOL among the study participants.ResultsAccording to SGRQ-C, the HRQOL of the study participants was greatly impaired with a total SGRQ of 55.2 (34–67.8). The highest impairment in the HRQOL was in the impact domain with a median of 58.7 (29–76.3). Increased number of prescribed medications (β = 1.157, P<0.01), older age (β = 0.487, P<0.001), male gender (β = 5.364, P<0.01), low education level (β = 9.313, P<0.001), low and moderate average income (β = 6.440, P<0.05, and β = 6.997, P<0.01, respectively) were associated with poorer HRQOL. On the other hand, being married (β = -17.122, P<0.001), living in rural area (β = -6.994, P<0.01), non-use of steroids inhalers (β = -3.859, P<0.05), not receiving long acting muscarinic antagonists (LAMA) (β = -9.269, P<0.001), not receiving LABA (β = -8.243, P<0.001) and being adherent to the prescribed medications (β = -6.016, P<0.001) were associated with improved HRQOL. Furthermore, lower disease severity (stage A, B, and C) (β = -23.252, -10.389, and -9.696 respectively, P<0.001), and the absence of comorbidities (β = -14.303, P<0.001) were associated with better HRQOL.ConclusionsIn order to maximize HRQOL in patients with COPD, future COPD management interventions should adopt a multidisciplinary approach involving different healthcare providers, which aims to provide patient-centered care, implement personalized interventions, and improve medication adherence, particularly for patients who are elderly, males, have low socioeconomic status, receive multiple medications and have multiple comorbid diseases.
Relationship between evacuation after the Great East Japan Earthquake and new-onset hyperuricemia: A 7-year prospective longitudinal study of the Fukushima Health Management Survey
Authors: Honda Kazuya , Okazaki Kanako , Tanaka Kenichi , Kobari Eri , Kazama Sakumi , Hashimoto Shigeatsu , Ohira Tetsuya , Sakai Akira , Yasumura Seiji , Maeda Masaharu , Yabe Hirooki , Hosoya Mitsuaki , Takahashi Atsushi , Harigane Mayumi , Nakano Hironori , Hayashi Fumikazu , Nagao Masanori , Shimabukuro Michio , Ohto Hitoshi , Kamiya Kenji , Kazama Junichiro J. 
Published: October 2023

Introduction
On March 11, 2011, the Great East Japan Earthquake occurred in Japan, with a nuclear accident subsequently occurring at the Fukushima Daiichi Nuclear Power Plant. The disaster forced many evacuees to change particular aspects of their lifestyles. However, the effect of evacuation on the new-onset of hyperuricemia have not been sufficiently elucidated. This study assessed the association between evacuation and new-onset hyperuricemia after the earthquake based on the Fukushima Health Management Survey from a lifestyle and socio-psychological perspective.

Materials and methods
This is a 7-year prospective longitudinal study included 18,140 residents (6,961 men and 11,179 women) with non-hyperuricemia who underwent both the Comprehensive Health Check and the Mental Health and Lifestyle Survey in fiscal year 2011. Associations between new-onset hyperuricemia and lifestyle- and disaster-related factors, including evacuation, were estimated using a Cox proportional hazards regression model analysis. Hyperuricemia was defined as uric acid levels > 7.0 mg/dL for men and > 6.0 mg/dL for women.

Results
During a median follow-up of 4.3 years, 2,996 participants (1,608 men, 23.1%, 1,388 women, 12.4%) newly developed hyperuricemia. Significant associations were observed between evacuation and onset of hyperuricemia in women (adjusted hazard ratio 1.18, 95% confidence interval, 1.05–1.32, p = 0.007), but not in men (adjusted hazard ratio 1.11, 95% confidence interval, 0.99–1.24, p = 0.067).

Discussion
Evacuation after a natural disaster is an independent risk factor for the new-onset of hyperuricemia in women. The possibility of hyperuricemia developing in response to natural disasters should be considered.
Para-perirenal fat thickness is associated with reduced glomerular filtration rate regardless of other obesity-related indicators in patients with type 2 diabetes mellitus
Authors: Xu Sunan , Ma Junqing , Zheng Yongze , Ren Ruichen , Li Wenting , Zhao Wei , Ma Yu , Zhou Tao , Zhang Yang 
Published: October 2023

PurposeTo investigate the relationship between estimated glomerular filtration rate (eGFR) and para-perirenal fat thickness in comparison with other indices of adiposity in type 2 diabetes mellitus (T2DM).MethodsThis single-center, retrospective and cross-sectional study evaluated 337 patients with T2DM. The obesity-related indicators including height, weight, body surface area (BSA), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), para-perirenal fat thickness (PRFT), total abdominal fat (TAF), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT). eGFR was calculated by CKD-EPI equation. The correlation between eGFR and obesity-related indicators was performed by pearson or spearman correlation analysis and multivariate linear regression.Results337 subjects (mean age, 60.2 ± 11.6 years; 195 males, 57.9%) were evaluated. eGFR was negatively correlated with height, weight, BMI, PRFT, TAF, SAT, and VAT, among which the correlation between eGFR and PRFT was the strongest (r = -0.294, p< 0.001). eGFR remained the strongest correlation with PRFT in the subgroup separated by sex (r = -0.319 in the male subgroup, and -0.432 in the female subgroup, respectively, p < 0.001). Age and PRFT were the independent predictive factors for eGFR. PRFT was the best predictor of chronic kidney disease (CKD) in T2DM (AUC = 0.686, p = 0.001, 95% CI: 0.582–0.791). CKD in T2DM can be predicted well by linking age with PRFT (AUC = 0.708, p<0.001, 95% CI = 0.605–0.812).ConclusionsPRFT is more closely related to glomerular filtration rate than other obesity-related indicators in T2DM. The model combining age with PRFT could predict CKD in T2DM well.
Nursing students’ perceived anxiety and heart rate variability in mock skill competency assessment
Authors: Wong Cho Lee , Chien Wai Tong , Waye Mary Miu Yee , Szeto Mark Wun Chung , Li Huiyuan 
Published: October 2023

Background
Skill competency assessments induce stress and anxiety and may affect nursing student performance. Little is known about stress and perceived anxiety levels and their relationship in the mock skill competency assessment.

Methods
A cross-sectional study was conducted to examine the stress levels (as assessed by heart rate variability, HRV) and perceived anxiety before, during and after the mock skill competency assessment, and to explore their relationships to performance in a total of ninety first-year undergraduate nursing students.

Results
The HRV decreased significantly during the assessment and increased significantly 10 min after the assessment (p < 0.01). Higher performers showed significantly lower HRV during and after the assessment (p < 0.01). The assessment score was negatively correlated with HRV during and after the assessment (p < 0.05).

Conclusions
Considering assessment-related stress and anxiety through a mock assessment prior to the actual skill assessment provides implications for future nursing education.
Mental illness and help-seeking behaviours among Middle Eastern cultures: A systematic review and meta-synthesis of qualitative data
Authors: Elshamy Farah , Hamadeh Ayah , Billings Jo , Alyafei Aisha 
Published: October 2023

Background
Western literature has long explored help-seeking behaviours related to mental health issues. However, this has been relatively neglected in the Middle East despite an increase in mental health needs in the region. The purpose of this review was to conduct a systematic review and qualitative meta-synthesis exploring help-seeking behaviours related to mental health issues in the Middle East.

Methods
We conducted a systematic review and meta-synthesis to gain a comprehensive overview of what is known about mental health and help-seeking behaviours in the Middle East from published qualitative research in the Middle Eastern region. A search of electronic databases (MEDLINE, Embase, CINAHL, PsycINFO and QScience) was carried out from inception to July 2022. The quality of the included studies was assessed using the Critical Appraisal Skills Programme tool, and the review protocol was pre-registered with PROSPERO (Ref: CRD42022311494).

Results
We identified 16 qualitative studies exploring mental health-seeking behaviours in Middle East countries. Facilitators and barriers to help-seeking were captured under six overarching themes. Across all studies, we identified negative attitudes towards seeking help for mental health issues, economic and structural barriers to accessing mental healthcare, and misconceptions surrounding religious beliefs, all of which had a critical role in impacting decisions to seek mental healthcare services. Many sought help from alternative sources, such as traditional healers or family members before consulting a healthcare professional. The role of the family and cultural norms was also identified as key contributors to people’s help-seeking behaviours.

Conclusions
This meta-synthesis indicates the existence of many challenges surrounding mental health-seeking in the Middle East, including public and internalizing stigmas. This suggests an urgent need for an increase in psychoeducation and mental health awareness in the region.
Endoscopic Internal Drainage Achieving Successful Closure of Iatrogenic Pharyngoesophageal Fistula
Authors: Rimawi Ahmad , Al-Turk Yahia , Swied Abdul Monem 
Published: October 2023

ABSTRACT
Endoscopic internal drainage (EID) is a minimally invasive endoscopic technique that effectively closes upper gastrointestinal fistulas. We report the successful closure of an oropharyngeal fistula in a 78-year-old man with a history of supraglottic squamous cell carcinoma. He presented with inspiratory stridor after biopsy of a lateral wall lesion in the piriformis sinus. Imaging showed a fistula tract between the piriformis sinus and the esophagus. EID was performed using a double-pigtail stent inserted inside the fistula. Eventually, repeat imaging showed evidence of fistula closure. To our knowledge, this is the first reported case of using EID for repairing an oropharyngeal fistula.
A Unique Management Strategy for Migrated Biliary Stent Causing Duodenal Perforation
Authors: Walradt Trent , Ryou Marvin , Shah Raj 
Published: October 2023

ABSTRACT
Distal stent migration leading to duodenal perforation is an uncommon complication of endoscopic biliary plastic stent placement. We present a case in which a patient with a migrated biliary plastic stent that perforated through the duodenum was managed expectantly until a duodenocolic fistula formed prior to endoscopic removal.
Analisis Sosial terhadap Program KPR Rumah Bersubsidi Perumahan Pesona Estetika Cikembulan di Kabupaten Pangandaran
Authors: Sugiyantoro Yayan , Sulardjaka Sulardjaka , Buchori Luqman 
Published: October 2023

Abstrak Backlog rumah di Indonesia masih sangat tinggi. Berdasarkan data sensus BPS pada tahun 2015 backlog perumahan di Indonesia untuk tahun 2015 adalah 11.459.875 unit. Hal ini berkaitan dengan kemampuan untuk memiliki rumah, khususnya masyarakat yang berpenghasilan rendah (MBR). Pemerintah meluncurkan program kepemilikan rumah bersubsidi dengan menggandeng perbankan dan developer yang terdaftar sebagai penyedia unit rumah yang dijual ke konsumen. Peneliti ingin melihat sejauh mana respon masyarakat terhadap program KPR Rumah Bersubsidi berdasarkan pengalaman peneliti sebagai pelaku pembangunan (developer) dengan mengambil studi kasus di salah satu perumahan bersubsidi yang peneliti kembangkan yaitu Perumahan Pesona Estetika Cikembulan di Kabupaten Pangandaran, Jawa Barat-Indonesia. Berdasarkan hasil penelitian, program KPR rumah subsidi ini mendapat respon yang sangat tinggi dari masyarakat, terbukti melalui penelitian yang dilakukan oleh Peneliti berdasarkan data penjualan dari perumahan bersubsidi yang dibangun pada tahun 2016, total sebanyak 51 unit rumah subsidi laku terjual dan diserah-terimakan ke konsumen hanya dalam jangka waktu kurang dari 1 tahun sejak dipasarkan. Hal ini tentu menjadi capaian yang positif bagi pemerintah karena menurunkan angka backlog perumahan. Pada pelaksanaannya di lapangan, mayoritas calon konsumen tidak hanya kalangan MBR ingin membeli rumah dengan skema subsidi, sehingga hal tersebut berpotensi terjadi manipulasi-manipulasi. Diperlukan komitmen yang tinggi dari semua stakeholder; pemerintah sebagai pembuat program untuk menerapkan aturan dan pengawasan, perbankan sebagai penyedia jasa keuangan tidak hanya capaiannya target KPR, dan tentunya yang paling penting adalah komitmen developer untuk menyaring calon konsumen yang benar-benar berkategori MBR untuk dapat membeli rumah subsidi sehingga program ini dapat berhasil dan tepat sasaran. Kata kunci: backlog; kpr subsidi; masyarakat berpenghasilan rendah; respon masyarakat; rumah subsidi
Continuous differentiability of a weak solution to very singular elliptic equations involving anisotropic diffusivity
Authors: Tsubouchi Shuntaro 
Published: October 2023

Abstract
In this paper we consider a very singular elliptic equation that involves an anisotropic diffusion operator, including the one-Laplacian, and is perturbed by a p-Laplacian-type diffusion operator with

1
<
p
<
∞

{1<p<\infty}

. This equation seems analytically difficult to handle near a facet, the place where the gradient vanishes. Our main purpose is to prove that weak solutions are continuously differentiable even across the facet. Here it is of interest to know whether a gradient is continuous when it is truncated near a facet. To answer this affirmatively, we consider an approximation problem, and use standard methods including De Giorgi’s truncation and freezing coefficient methods.
Global sharp gradient estimates for a nonlinear parabolic equation on Riemannian manifolds
Authors: Chuan Le Huy , Dung Nguyen Thac , Manh Nguyen Tien 
Published: October 2023

Abstract
In this paper, we employ the techniques in
[C. Cavaterra, S. Dipierro, Z. Gao and E. Valdinoci,
Global gradient estimates for a general type of nonlinear parabolic equations,
J. Geom. Anal. 32 2022, 2, Paper No. 65]
and the approach in
[H. T. Dung and N. T. Dung,
Sharp gradient estimates for a heat equation in Riemannian manifolds,
Proc. Amer. Math. Soc. 147 2019, 12, 5329–5338]
to derive sharp gradient estimates for a positive solution to the heat equation

u
t

=

Δ
⁢
u

+

a
⁢
u
⁢

log
⁡
u

u_{t}=\Delta u+au\log u

in a complete noncompact Riemannian manifold (where a is a real constant). This is an extension of the gradient estimates of Dung and Dung.
Biomechanical comparison of three fixation strategies for radial head fractures: a biomechanical study
Authors: Tsai Yao-Tung , Lin Kun-Jhih , Lin Jui-Cheng 
Published: October 2023

Abstract
Second-generation headless compression screws (HCSs) are commonly used for the fixation of small bones and articular fractures. However, there is a lack of biomechanical data regarding the application of such screws to radial head fractures. This study evaluated the mechanical properties of the fixation of radial head fractures using a single oblique HCS compared with those obtained using a standard locking radial head plate (LRHP) construct and a double cortical screw (DCS) construct. Radial synbone models were used for biomechanical tests of HCS, LRHP, and DCS constructs. All specimens were first cyclically loaded and then loaded to failure. The stiffness for the LRHP group was significantly higher than that for the other two groups, and that for the HCS group was significantly higher than that for the DCS group. The LRHP group had the greatest strength, followed by the HCS group and then the DCS group. The HCS construct demonstrated greater fixation strength than that of the commonly used cortical screws, although the plate group was the most stable. The present study revealed the feasibility of using a single oblique HCS, which has the advantages of being buried, requiring limited wound exposure, and having relatively easy operation, for treating simple radial head fractures.
Pediatric reference intervals for serum neurofilament light and glial fibrillary acidic protein using the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort
Authors: Stukas Sophie , Cooper Jennifer , Higgins Victoria , Holmes Daniel , Adeli Khosrow , Wellington Cheryl L. 
Published: October 2023

Abstract

Objectives
Blood biomarkers have the potential to transform diagnosis and prognosis for multiple neurological indications. Establishing normative data is a critical benchmark in the analytical validation process. Normative data are important in children as little is known about how brain development may impact potential biomarkers. The objective of this study is to generate pediatric reference intervals (RIs) for serum neurofilament light (NfL), an axonal marker, and glial fibrillary acidic protein (GFAP), an astrocytic marker.

Methods
Serum from healthy children and adolescents aged 1 to <19 years were obtained from the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort. Serum NfL (n=300) and GFAP (n=316) were quantified using Simoa technology, and discrete RI (2.5th and 97.5th percentiles) and continuous RI (5th and 95th percentiles) were generated.

Results
While there was no association with sex, there was a statistically significant (p<0.0001) negative association between age and serum NfL (Rho −0.400) and GFAP (Rho −0.749). Two statistically significant age partitions were generated for NfL: age 1 to <10 years (lower, upper limit; 3.13, 20.6 pg/mL) and 10 to <19 years (1.82, 7.44 pg/mL). For GFAP, three statistically significant age partitions were generated: age 1 to <3.5 years (80.4, 601 pg/mL); 3.5 to <11 years (50.7, 224 pg/mL); and 11 to <19 years (26.2, 119 pg/mL).

Conclusions
Taken together with the literature on adults, NfL and GFAP display U-shaped curves with high levels in infants, decreasing levels during childhood, a plateau during adolescence and early adulthood and increasing levels in seniors. These normative data are expected to inform future pediatric studies on the importance of age on neurological blood biomarkers.
The p-Bohr radius for vector-valued holomorphic and pluriharmonic functions
Authors: Das Nilanjan 
Published: October 2023

Abstract
We study a “p-powered” version

K
n
p

⁢

(

F
⁢

(
R
)

)

{K_{n}^{p}(F(R))}

of the well-known Bohr radius problem for the family

F
⁢

(
R
)

{F(R)}

of holomorphic functions

f
:

R
→
X

{f:R\to X}

satisfying

∥
f
∥

<
∞

{\lVert f\rVert<\infty}

, where

∥
⋅
∥

{\lVert\,\cdot\,\rVert}

is a norm in the function space

F
⁢

(
R
)

{F(R)}

,

R
⊂

ℂ
n

{R\subset{\mathbb{C}}^{n}}

is a complete Reinhardt domain, and X is a complex Banach space. For all

p
>
0

{p>0}

, we describe in full detail the asymptotic behavior of

K
n
p

⁢

(

F
⁢

(
R
)

)

{K_{n}^{p}(F(R))}

, where

F
⁢

(
R
)

{F(R)}

is: (a) the Hardy space of X-valued holomorphic functions defined in the open unit polydisk

𝔻
n

{{\mathbb{D}}^{n}}

; and (b) the space of bounded X-valued holomorphic or complex-valued pluriharmonic functions defined in the open unit ball

B
⁢

(

l
t
n

)

{B(l_{t}^{n})}

of the Minkowski space

l
t
n

{l_{t}^{n}}

. We give an alternative definition of the optimal cotype for a complex Banach space X in the light of these results.
In addition, the best possible versions of two theorems from
[C. Bénéteau, A. Dahlner and D. Khavinson,
Remarks on the Bohr phenomenon,
Comput. Methods Funct. Theory 4 2004, 1, 1–19]
and
[S. Chen and H. Hamada,
Some sharp Schwarz–Pick type estimates and their applications of harmonic and pluriharmonic functions,
J. Funct. Anal. 282 2022, 1, Paper No. 109254]
have been obtained as specific instances of our results.
On skew derivations and antiautomorphisms in prime rings
Authors: Alali Amal S. , Alnoghashi Hafedh , Nisar Junaid , ur Rehman Nadeem , Alqarni Faez A. 
Published: October 2023

Abstract
According to Posner’s second theorem, a prime ring is forced to be commutative if a nonzero centralizing derivation exists on it. In this article, we extend this result to prime rings with antiautomorphisms and nonzero skew derivations. Additionally, a case is shown to demonstrate that the restrictions placed on the theorems’ hypothesis were not unnecessary.