bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost of ambulatory care of diabetes mellitus: a study from north India
Authors: Grover S , Avasthi A , Bhansali A , Chakrabarti S , Kulhara P 
Published: June 2005

Abstract

Background
Diabetes mellitus is a chronic and potentially disabling disease that represents an important public health and clinical concern because of the economic burden it imposes on the person, family, and society. Despite this, data regarding cost of care of diabetes mellitus from developing countries are scarce. This study aimed to assess the cost of care of Indian patients with diabetes mellitus.

Methods
Cost of illness in 50 outpatients with diabetes mellitus (diagnosed according to WHO criteria, Expert Committee, 1997) was assessed over a six month period using a specially designed questionnaire, together with structured assessments of disability.

Results
Total annual cost of care was 14 508 rupees (263.78 euros). The largest proportion of the total cost was made up of direct costs (68%), followed by indirect costs (28.76%) and provider’s costs (2.8%). Drug costs were high. Total treatment cost was significantly higher in those who were more educated, those who visited the hospital more often, and those receiving a greater number of drugs.

Conclusion
From this study it can be concluded that diabetes mellitus is an expensive illness to treat even in developing countries. The main brunt of financial burden is borne by the family. Any efforts at cost reduction should, therefore, have the family as its focus, and relieving the family of this financial burden needs to be prioritised.
Direct thrombin inhibitors: novel antithrombotics on the horizon in the thromboprophylactic management of atrial fibrillation
Authors: Katira R , Chauhan A , More R S 
Published: June 2005

AbstractAntithrombotic agents have verified efficacy in reducing the thromboembolic risk associated with atrial fibrillation. This article focuses on the emergence of a new oral direct thrombin inhibitor, ximelagatran, into the arena of atrial fibrillation thromboprophylaxis. This review does not cover atrial fibrillation in the context of valvular heart disease. The efficacy of aspirin and warfarin will be discussed briefly.
Management of chronic hepatitis C
Authors: Lo Re V , Kostman J R 
Published: June 2005

AbstractHepatitis C virus (HCV) infection is transmitted primarily through percutaneous exposure to blood, and most infections are associated with injection drug use. Progression to chronic HCV occurs in 55% to 86% of infected people, and persistent infection is a major cause of cirrhosis, end stage liver disease, and hepatocellular carcinoma. The detection of HCV antibodies should be performed initially to screen at risk populations. In those who are seropositive, HCV viraemia should be assessed to determine if chronic HCV is present. The HCV genotype should also be determined, as this is the strongest predictor of response to available treatment. A liver biopsy is very often helpful because it can estimate degree of hepatic fibrosis, identify concurrent diseases that might contribute to hepatic injury, and aid in selection of patients for treatment. The decision to start antiviral therapy should take into account potential contraindications to therapy, patient motivation, severity of disease, age, and HCV genotype. Combination therapy with weekly subcutaneous pegylated interferon and daily oral ribavirin is the standard of care for treating patients with chronic HCV.
Evaluation of the status of tuberculosis as part of the clinical case definition of AIDS in India
Authors: Attili V S S , Singh V P , Rai M , Varma D V , Sundar S 
Published: June 2005

Abstract

Aim
To assess HIV associated tuberculosis in a high tuberculosis prevalence setting and its status in the clinical case definition of AIDS.

Methods
All HIV patients attending the infectious disease clinic, Varanasi, India between January 2001 and December 2003 were included in the study. They were stratified into three distinct immunological categories depending on their CD4 levels in accordance to Centers for Disease Control (CDC) classification. Tuberculosis of different organs was defined as detailed below.

Results
Tuberculosis was the commonest opportunistic disease, seen in 163 patients. Of these, 68 had exclusively pulmonary tuberculosis, 55 extrapulmonary disease, and 40 the disseminated form. Pulmonary and extrapulmonary tuberculosis had low positive predictive value (PPV) (51% and 42%) for CD4 levels of &lt;200 when compared with the disseminated form (specificity 87% and PPV 75%). Among 86 patients with radiological evidence of tuberculosis, typical radiological features of post-primary tuberculosis were present in 60 cases (70%). Other features such as effusion (14 patients, 16%) and miliary shadows (12 patients, 14%) were comparatively rare.

Conclusion
Keeping pulmonary and extrapulmonary forms of tuberculosis in AIDS defining illness should be reconsidered. In a similar way tuberculosis in HIV patients from areas endemic with tuberculosis occurs in patients with a wide range of immune status and has a better prognosis than other AIDS defining illnesses. Therefore the inclusion of tuberculosis in clinical case definition of AIDS is not justified.
Advances in wound healing: topical negative pressure therapy
Authors: Jones S M , Banwell P E , Shakespeare P G 
Published: June 2005

Abstract
In clinical practice many wounds are slow to heal and difficult to manage. The recently introduced technique of topical negative pressure therapy (TNP) has been developed to try to overcome some of these difficulties. TNP applies a controlled negative pressure to the surface of a wound that has potential advantages for wound treatment and management. Although the concept itself, of using suction in wound management is not new, the technique of applying a negative pressure at the surface of the wound is. This paper explores the origins and proposed mechanisms of action of TNP therapy and discusses the types of wounds that are thought to benefit most from use of this system.
Cognitive aging and Alzheimer’s disease
Authors: Vandenberghe R , Tournoy J 
Published: June 2005

AbstractCognitive aging and clinically probable Alzheimer’s disease can be discriminated by means of clinical and neuropsychological testing, and structural and functional imaging techniques. Research at the level of cognitive brain systems and at the molecular level provides exciting new insights into the relation between aging and neurodegeneration. The advances at the clinical and at the basic research levels are necessary if we wish to meet the formidable challenge that the increasing prevalence of Alzheimer’s disease poses to the medical community.
PATH PROPERTIES OF THE LINEAR MULTIFRACTIONAL STABLE MOTION
Authors: STOEV STILIAN , TAQQU MURAD S. 
Published: June 2005

The linear multifractional stable motion (LMSM) processes Y = {Y(t)}t∈ℝis an α-stable (0 < α < 2) stochastic process, which exhibits local self-similarity, has heavy tails and can have skewed distributions. The process Y is obtained from the well-known class of linear fractional stable motion (LFSM) processes by replacing their self-similarity parameter H by a function of time H(t).We show that the paths of Y(t) are bounded on bounded intervals only if 1/α ≤ H(t) < 1, t ∈ ℝ. In particular, if 0 < α ≤ 1, then Y has everywhere discontinuous paths, with probability one. On the other hand, Y has a version with continuous paths if H(t) is sufficiently regular and 1/α < H(t), t ∈ ℝ. We study the Hölder regularity of the sample paths when these are continuous and establish almost sure bounds on the pointwise and uniform pointwise Hölder exponents of the (random) function Y(t,ω), t ∈ ℝ, in terms of the function H(t) and its corresponding Hölder exponents.The Gaussian multifractional Brownian motion (MBM) processes are LMSM processes when α = 2. We obtain some new results on the Hölder regularity of their paths.
Western Esotericism and the Science of Religions
Authors: Voss Karen-Claire , Faivre Antoine 
Published: June 2005

AbstractThe term “esotericism” refers here to the modern esoteric currents in the West (15th to 20th centuries), i.e. to a diverse group of works, authors, trends, which possess an “air de famille” and which must be studied as a part of the history of religions because of the specific form it has acquired in the West from the Renaissance on. This field is comprised of currents like: alchemy (its philosophical and/or “spiritual” aspects); the philosophia occulta; Christian Kabbalah; Paracelsianism and the Naturphilosophie in its wake; theosophy (Jacob Boehme and his followers, up to and including the Theosophical Society); Rosicrucianism of the 17th century and the subsequent similarly-oriented initiatic societies; and hermetism, i.e. the reception of the Greek Hermetica in modern times.
Authority and Orality in the Mahāyāna
Authors: Lopez Donald 
Published: June 2005

AbstractThe Mahāyāna sūtras, acknowledged by scholars to have been composed centuries after the death of the Buddha, almost invariably begin with the stock phrase, “thus did I hear,” thereby maintaining the conceit of orality. The paper explores the role of this orality as it figures in strategies of authority for the Mahāyāna sūtras in Indian Buddhism. The paper considers at some length recent scholarship (notably that of Richard Gombrich) on the question of when Buddhist texts were first written down, in light of the widely read but highly problematic theories of orality put forth by Walter Ong and Jack Goody. The paper next compares the positions on speech (and by extension, orality) in the Mīmāmsaka view of the Vedas and in the Buddhist view of the word of the Buddha. Although Buddhist scholastics devoted a great deal of energy to attacking the Mīmāmsaka position of the eternal nature of the Vedas as sound and although scholars have tended to regard the Hindu and Buddhist positions as antithetical, there are significant unacknowledged affinities between the Mīmāmsaka and Buddhist positions which help explain why the Mahāyāna sūtras begin, “thus did I hear.” The paper concludes with a discussion of the possible significance of writing in the rise of the diverse association of cults of the book which we have come to call the Mahāyāna.
Relation between oxidation/crystallization and degassing upon reheating of basalt glass from Kilauea, Hawaii
Authors: Burkhard D. J. M. 
Published: June 2005

AbstractBasalt glass from Kilauea, Hawaii (SBG) starts to crystallize upon heat treatment in air at ∽840°C. In addition, oxidation takes place. The kinetics of both processes may be readily quantified though the mechanism is difficult to access. This work investigates the relationship between these processes, crystallization and oxidation, and the escape of volatiles from the glass/liquid upon reheating. Evolved gas analyses and differential scanning calorimetry are the techniques used. In addition, isothermal heat treatment in argon is carried out in order to eliminate the external reason for oxidation, the oxygen gradient, and to focus on intrinsic oxidation. Products are examined with 57Fe Mössbauer spectroscopy. As expected, degassing temperatures of SBG, and of two MORB samples, considered for comparison, are above the glass transition temperature. We find no convincing evidence of intrinsic oxidation. Degassing is likely to induce interface-controlled crystallization.
Ilmenite exsolution in olivine from the serpentinite body at Zöblitz, Saxonian Erzgebirge – microstructural evidence using EBSD
Authors: Massonne H.-J. , Neuser R. D. 
Published: June 2005

AbstractIn the large serpentinite body at Zöblitz, which is part of the Gneiss-Eclogite Unit of the Saxonian Erzgebirge, ilmenite rods have been detected in olivine. Although these rods are ≤1 μm wide, they can be unequivocally identified as ilmenite using electron backscatter diffraction. We also applied this method to prove that ilmenite is topotactically intergrown with the olivine host ([100]ol ‖ [001]ilm). This relation was found previously, e.g. for ilmenite exsolved from olivine of garnet peridotite from Alpe Arami, Swiss Alps. The degree of this exsolution phenomenon in the Alpe Arami rocks was taken as an indication of the original formation of a Ti-bearing mineral at depths of ∽300 km. As in the olivines of the serpentinite from Zöblitz, the density of the ilmenite rods is significantly less than in the rock from Alpe Arami. We think that our observation is compatible with previous P-T estimates of close to 4 GPa and 1000–1100°C for the ultramafic bodies in the central Saxonian Erzgebirge.
A silica-deficient, shallow-marine zeolite assemblage in the Foveaux Formation, Bluff Peninsula, New Zealand
Authors: Coombs D. S. , Bosel C. A. , Kawachi Y. , Paterson L. A. 
Published: June 2005

AbstractA gonnardite-thomsonite-chabazite-calcite assemblage forms a cement in the Foveaux Formation, a fossiliferous gabbroic boulder bed that accumulated at the base of a sea cliff cut in a Permian igneous complex during late Oligocene±early Miocene time. Gonnardite was the earliest zeolite to form, locally following minor calcite. It was followed epitaxially by thomsonite, co-precipitating with chabazite. Crystal habits indicate a low-temperature origin. The maximum temperature to which the deposit may have been subjected is estimated as not more than ∽30°C. The chabazites are Ca-poor chabazite-K and chabazite-Na. Representative electron microprobe analyses are as follows, all + nH2O:thomsonite: Na3.77Ca7.73(Al19.39Si20.65)O80 and Na3.78K0.04Ca7.25Mg0.05(Al19.13Si21.05)O80;gonnardite: Na6.95K0.03Ca4.73(Al16.99Si23.15)O80 and Na8.56K0.03Ca4.05(Al17.32Si22.84)O80;chabazite-K: Na1.18K1.72Ca0.08Mg0.23(Al3.51Si8.49)O24 and Na1.67K1.92Ca0.18Mg0.17(Al4.11Si7.85)O24;chabazite-Na: Na2.51K1.13Ca0.17Mg0.02(Al4.08Si7.93)O24.Such a Si-poor zeolite assemblage is unusual for marine sediments and is attributed to precipitation from marine water impoverished in silica in the gabbroic boulder bed and interacting with shell material and calcic plagioclase. In contrast, a dioritic clast in the boulder bed provides an example of less silica-poor zeolites originally formed in the parent igneous complex. Veinlets in the clast contain scolecite averaging Na1.19Ca7.36(Al15.84Si24.14)O80.nH2O, and mesolite averaging Na5.13K0.03Ca5.24 (Al15.93Si24.13)O80.nH2O, in part as sub-microscopic intergrowths. The composition of scolecite closely corresponds to the most Na-rich scolecite reported hitherto.
Identification of mixite minerals – an SEM and Raman spectroscopic analysis
Authors: Frost R. L. , Weier M. , Martens W. , Duong L. 
Published: June 2005

AbstractTwo mixites from Boss Tweed Mine, Tintic District, Juab County, Utah and Tin Stope, Majuba Hill, Pershing County, Nevada, USA, were analysed by scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis and by Raman spectroscopy. The SEM images show the mixite crystals to be elongated fibres up to 200 μm long and 2 μm wide. Detailed images of the mixite crystals show the mineral to be composed of bundles of fibres. The EDX analyses depend on the crystal studied, though the Majuba mixite gave analyses which matched the formula BiCu6(AsO4)3(OH)6.3H2O. Raman bands observed in the 880–910 cm−1 and 867–870 cm−1 regions are assigned to the AsO-stretching vibrations of (HAsO4)2− and (H2AsO4)− units, whilst bands at 803 and 833 cm−1 are assigned to the stretching vibrations of uncomplexed (AsO4)3- units. Intense bands observed at 473.7 and 475.4 cm−1 are assigned to the v4 bending mode of AsO4 units. Bands observed at 386.5, 395.3 and 423.1 cm−1 are assigned to the v2 bending modes of the HAsO4 (434 and 400 cm−1) and the AsO4 groups (324 cm−1). Raman spectroscopy lends itself to the identification of minerals on host matrices and is especially useful for the identification of mixites.
Determination of the Eu(II)/Eu(III) ratios in minerals by X-ray absorption near-edge structure (XANES) and its application to hydrothermal deposits
Authors: Takahashi Y. , Kolonin G. R. , Shironosova G. P. , Kupriyanova I. I. , Uruga T. , Shimizu H. 
Published: June 2005

AbstractEuropium LIII-edge X-ray absorption near-edge structure (XANES) was employed to determine the Eu(II)/Eu(III) ratios in minerals. This ratio can be determined based on the peak-area ratio of white lines, the resonance peak, in normalized XANES spectra for Eu(II) and Eu(III) species. For precise determination of the Eu(II)/Eu(III) ratios, however, it was revealed that the transition probabilities for each individual Eu(II) and Eu(III) species in the system must be quantified, because we found that the peak area in normalized XANES spectra is different in each Eu(II) and Eu(III) species. Despite this ambiguity, the method was applied to Eu in natural hydrothermal apatites (Eu = 39 and 64 ppm) and fluocerite (Eu = 282 ppm). The relationship between the Eu(II)/Eu(III) ratio in these hydrothermal minerals, and the distribution coefficients of Eu(II) and Eu(III) were discussed, taking into account Eu anomalies in their REE patterns. It is considered that by combining the Eu(II)/Eu(III) ratios determined by XANES and the degree of Eu anomaly in REE patterns, we can provide new information on the distribution of Eu(II) and Eu(III) in various geochemical studies.
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
Authors: Giuliani Nicola , Colla Simona , Morandi Francesca , Lazzaretti Mirca , Sala Roberto , Bonomini Sabrina , Grano Maria , Colucci Silvia , Svaldi Mirija , Rizzoli Vittorio 
Published: June 2005

AbstractDecreased bone formation contributes to the development of bone lesions in multiple myeloma (MM) patients. In this study, we have investigated the effects of myeloma cells on osteoblast formation and differentiation and the potential role of the critical osteoblast transcription factor RUNX2/CBFA1 (Runt-related transcription factor 2/core-binding factor Runt domain α subunit 1) in the inhibition of osteoblastogenesis in MM. We found that human myeloma cells suppress the formation of human osteoblast progenitors in bone marrow (BM) cultures. Moreover, an inhibitory effect on osteocalcin, alkaline phosphatase, collagen I mRNA, protein expression, and RUNX2/CBFA1 activity by human preosteoblastic cells was observed in cocultures with myeloma cells. The inhibitory effect was more pronounced in the cell-to-cell contact conditions compared with those without the contact and involved the very late antigen 4 (VLA-4) integrin system. Among the soluble osteoblast inhibitors screened, we show the potential contribution of interleukin-7 (IL-7) in the inhibitory effect on osteoblast formation and RUNX2/CBFA1 activity by human myeloma cells in coculture. Finally, our in vitro results were supported in vivo by the finding of a significant reduction in the number of Runx2/Cbfa1-positive cells in the BM biopsies of patients with MM who had osteolytic lesions compared with those who did not have bone lesions, suggesting the critical involvement of RUNX2/CBFA1 in the decreased bone formation in MM. (Blood. 2005;106:2472-2483)
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells
Authors: Baumforth Karl R. N. , Flavell Joanne R. , Reynolds Gary M. , Davies Gillian , Pettit Trevor R. , Wei Wenbin , Morgan Susan , Stankovic Tanya , Kishi Yasuhiro , Arai Hiroyuki , Nowakova Marketa , Pratt Guy , Aoki Junken , Wakelam Michael J. O. , Young Lawrence S. , Murray Paul G. 
Published: June 2005

AbstractA proportion of patients with Hodgkin lymphoma carry Epstein-Barr virus (EBV), an oncogenic herpesvirus, in their tumor cells. Although it is generally assumed that EBV contributes to the malignant phenotype of Hodgkin lymphoma cells, direct evidence in support of this is lacking. Here we show that EBV infection of Hodgkin lymphoma cells results in the induction of autotaxin, a secreted tumor-associated factor with lysophospholipase-D activity. Up-regulation of autotaxin increased the generation of lysophosphatidic acid (LPA) and led to the enhanced growth and survival of Hodgkin lymphoma cells, whereas specific down-regulation of autotaxin decreased LPA levels and reduced cell growth and viability. In lymphoma tissues, autotaxin expression was mainly restricted to CD30+ anaplastic large-cell lymphomas and Hodgkin lymphoma; in the latter, high levels of autotaxin were strongly associated with EBV positivity (P = .006). Our results identify the induction of autotaxin and the subsequent generation of LPA as key molecular events that mediate the EBV-induced growth and survival of Hodgkin lymphoma cells and suggest that this pathway may provide opportunities for novel therapeutic intervention. (Blood. 2005;106:2138-2146)
Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo
Authors: Little Mark A. , Smyth C. Lucy , Yadav Rashmi , Ambrose Lyn , Cook H. Terence , Nourshargh Sussan , Pusey Charles D. 
Published: June 2005

AbstractSystemic small vessel vasculitis is associated with antineutrophil cytoplasm antibodies (ANCAs). While there is mounting in vitro evidence to suggest that ANCAs are capable of enhancing leukocyte-endothelial interactions, no in vivo evidence for this has been provided. In this study a novel rat model of ANCA-associated experimental autoimmune vasculitis (EAV), induced by immunization with human myeloperoxidase (MPO), was used to analyze directly the potential effect of ANCAs on leukocyte-venular wall interactions in vivo as observed by intravital microscopy. These rats developed anti-MPO antibodies directed against rat leukocytes, showed pathologic evidence of small vessel vasculitis, and had enhanced leukocyte adhesion and transmigration in response to the chemokine Groα (CXCL1 [CXC ligand 1]). Passive transfer of immunoglobulin from rats with EAV to naive rats conferred enhanced adhesion and transmigration responses in the recipients. Furthermore, rats with EAV and recipients of ANCA-positive immunoglobulin developed extensive microvascular injury, as manifested by mesenteric hemorrhage, in response to CXCL1. This study provides the first direct in vivo evidence for the ability of ANCAs to enhance leukocyteendothelial interactions and cause microvascular hemorrhage, thereby providing a mechanism by which ANCAs could exert pathogenic effects in systemic vasculitis. (Blood. 2005;106:2050-2058)
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells
Authors: Calmels Boris , Ferguson Cole , Laukkanen Mikko O. , Adler Rima , Faulhaber Marion , Kim Hyeoung-Joon , Sellers Stephanie , Hematti Peiman , Schmidt Manfred , von Kalle Christof , Akagi Keiko , Donahue Robert E. , Dunbar Cynthia E. 
Published: June 2005

Abstract
Recent reports linking insertional activation of LMO2 following gene therapy for X-linked severe combined immunodeficiency (X-SCID) have led to a re-evaluation of risks following gene therapy with retroviral vectors. In our analysis of 702 integration sites in rhesus macaques that underwent transplantation up to 7 years earlier with autologous CD34+ cells transduced with amphotropic murine leukemia virus (MLV)-derived retroviral vectors containing marker genes, we detected insertion into one locus, the Mds1/Evi1 region, a total of 14 times in 9 animals. Mds1/Evi1 integrations were observed stably long term, primarily in myeloid cells. We hypothesize that this over-representation likely results from an impact on the self-renewal and engraftment potential of CD34+ progenitor cells via insertional mutagenesis at this specific locus. There is no evidence of ongoing in vivo clonal expansion of the Mds1/Evi1 populations, and all animals are hematologically normal without evidence for leukemia. Characterization of integration sites in this relevant preclinical model provides critical information for gene therapy risk assessment as well as identification of genes controlling hematopoiesis. (Blood. 2005;106:2530-2533)