bluuebunny/crossref_metadata_2025_split huggingface dataset:
A User Pairing Algorithm for the Uplink NOMA With Imperfect CSI
Authors: Sameti Zahra , Abolhassani Bahman , Farahmand Shahrokh 
Published: January 2025

ABSTRACTIn this paper, the problem of user pairing across subcarriers is investigated for the uplink non‐orthogonal multiple‐access (NOMA) systems, in which every subcarrier is assigned to exactly two users. Considering fixed transmit power for all users, we pair users such that sum‐rate is maximized over all subcarriers. While different (near) optimum allocation schemes exist in the literature, they pertain to perfect channel state information (CSI), which is impractical. To overcome this limitation, we assume statistical CSI is available in the form of the first two moments of channel gains. Then, we maximize a lower bound on the sum rate over user pairings utilizing a block coordinate ascent (BCA) approach with guaranteed convergence to a suboptimal solution. Numerical results corroborate a satisfactory performance for our proposed algorithm versus the perfect CSI benchmark and a simple random assignment approach. For high signal to noise ratios (SNRs) and the more challenging frequency selective fading setup, the solution of our proposed algorithm comes close to those of the optimal pairing with perfect CSI. Furthermore, simulations revealed that if the proposed BCA is utilized assuming perfect CSI, it performs similar to the well‐known global optimum in the frequency flat fading setup and outperforms the best existing near‐optimal solution in the frequency selective fading scenario. These observations offer a testament to the strength of the proposed BCA algorithm in both perfect and imperfect CSI conditions.
Novel Distributed Downlink Resource Allocation Methods for Heterogeneous Networks
Authors: Altin Ilke , Akar Mehmet 
Published: January 2025

ABSTRACTThis paper proposes novel distributed subchannel and power allocation algorithms for heterogeneous networks. First, we introduce a subchannel allocation algorithm that minimizes the maximum effective interference experienced by users in the network. We analytically prove that the proposed subchannel allocation algorithm minimizes the effective interference in the network. Subsequently, two power control algorithms are presented for the power allocation problem, and their convergence analysis is given. Afterward, the improvement in throughput by utilizing the proposed power control algorithm is shown by simulations. Finally, the proposed subchannel and power allocation algorithms are combined to form a joint resource allocation method, which is shown to outperform existing distributed resource allocation methods in the literature.
Recent Update on Teledermatology
Authors: Babaei Mahsa , Gholizadeh Nasim , Rokni Ghasem Rahmatpour 
Published: January 2025

ABSTRACTIntroductionTeledermatology, a branch of telemedicine, utilizes telecommunication technologies for remote dermatological care, covering diagnosis, treatment planning, and patient monitoring. This study presents a review of the latest advances in teledermatology.MethodDatabase searches were performed within PubMed, EMBase, and Google Scholar using the keywords “Artificial Intelligence,” “Teledermatology,” “Telemedicine,” and “Dermatology.” All relevant documents were screened and included in the study.ResultsTeledermatology employs synchronous and asynchronous interactions alongside remote monitoring, breaking geographical barriers to access dermatologic expertise. Supported by digital imaging, secure communication platforms, and artificial intelligence, teledermatology aids in diagnosis, treatment, and follow‐up. In education, teledermatology facilitates remote learning, case review, and interdisciplinary collaboration, providing access to diverse patient populations and mentorship opportunities. It also contributes to continuing medical education and telemedicine skill development. In research, teledermatology supports epidemiological studies, diagnostic accuracy assessments, clinical trials, and quality improvement initiatives. Despite its benefits, challenges like image quality, regulatory issues, and the digital divide persist.ConclusionThe evolution of teledermatology depends on technological advancements, regulatory frameworks, and reimbursement models. By addressing challenges and embracing innovation, teledermatology promises to enhance dermatologic care, patient outcomes, and healthcare efficiency in the digital era.
Continuous risk monitoring and management of heart failure: Rationale and design of the ALLEVIATE‐HF trial
Authors: Butler Javed , Kahwash Rami , Khan Muhammad Shahzeb , Gerritse Bart , Laechelt Aimee , Wehking Jennifer , Sarkar Shantanu , van Dorn Brian , Laager Verla , Patel Nirav , Zile Michael R. ,   on behalf of the ALLEVIATE‐HF Investigators
Published: January 2025

AbstractAimsEarly identification and management of worsening heart failure (HF) is necessary to prevent disease progression and hospitalizations. The ALLEVIATE‐HF (Algorithm Using LINQ Sensors for Evaluation and Treatment of Heart Failure) trial is a prospective, randomized, controlled, double‐blind, multicentre trial that aims to assess the safety and efficacy of using the Reveal LINQ™ insertable cardiac monitor (ICM) in patients with HF to continuously monitor and evaluate HF risk status and guide timely interventions.MethodsThe ICM algorithm uses parameters derived from electrocardiogram (atrial fibrillation [AF], ventricular rate during AF, heart rate variability, and night heart rate), three‐axis accelerometer (patient activity duration), and subcutaneous bioimpedance (fluid volume, respiration rate). The trial will enroll ~760 patients with New York Heart Association class II or III HF with recent hospitalization for HF or needing intravenous diuretics in the outpatient setting or elevated natriuretic peptide levels, who do not have an implanted cardiac implantable electronic device or haemodynamic monitor. Patients are randomized to an observation or an intervention arm, where the latter will receive an intervention pathway with remote nurses implementing individualized pro re nata (PRN or ‘as needed’) 4‐day medication interventions for acute volume management upon high risk. After 13 months of randomized follow‐up, all patients enter an unblinded prolonged follow‐up phase with PRN interventions upon high risk. The primary hierarchical composite endpoint for the study includes cardiovascular death, HF events, Kansas City Cardiomyopathy Questionnaire score, and 6‐min walk test distance.ConclusionALLEVIATE‐HF will evaluate how ICM‐based HF management can impact the outcomes of patients with HF regardless of ejection fraction.
Pitfalls in Early Bioprocess Development Using Shake Flask Cultivations
Authors: Brauneck Gesa , Engel Dominik , Grebe Luca Antonia , Hoffmann Maximilian , Lichtenberg Philipp Georg , Neuß Anne , Mann Marcel , Magnus Jorgen Barsett 
Published: January 2025

ABSTRACTFor about 100 years, the shake flask has been established for biotechnological cultivations as one of the most important cultivation systems in early process development. Its appeal lies in its simple handling and highly versatile application for a wide range of cell types—from bacteria to mammalian cells. In recent decades, extensive research has been conducted on the shake flask, to not perform processes blindly but to gain a deeper understanding of the various process parameters, phenomena, and their impact on the process. Although the characterization of the shake flask is now well‐established in literature, many publications show that this knowledge is often inadequately applied. Therefore, this review provides an overview of the current state of knowledge on various topics related to the shake flask. We first present the key process parameters and their influence on different physical phenomena, such as power input, the largely unknown in‐phase/out‐of‐phase phenomenon, as well as temperature and mass transfer. Then, the most common online monitoring systems that have been established for shake flasks are discussed. Finally, various pitfalls that often arise from inadequate knowledge of handling shake flask cultivations are discussed and guidance on how to avoid them is provided.
Effective Charging Scheduling of Electric Vehicles Using a Hybrid Deep Learning Network
Authors: Ananth J. P. , Kumar Pankaj , Belsam Jeba Ananth M. , Cristin R. 
Published: January 2025

ABSTRACTElectric vehicles (EVs) are developed by diverse industries as a substitute for vehicles with internal combustion engines, with many compensations that are environment‐friendly. The amount of EVs is likely to rise fast in the approaching ages. However, uncoordinated vehicle charging may significantly stress the power grid. The main objective of the devised model is to minimize the charging time and waiting time for EVs by distributing equal power resources. Therefore, an energy‐aware multi‐objective system in a cloud‐internet of things (IoT)‐based electric vehicular network for a priority‐based charge‐scheduling scheme is proposed here and established as follows. Initially, the network with the EV location as well as the charge station (CS) location is simulated. Then, the charging planning is performed by determining the CS selection using the fractional spotted hyena jellyfish optimization (FSHJSO) considering a multi‐objective function. Subsequently, the charge scheduling is performed using the established hybrid deep learning (DL) approach namely MobileNet neural network (MNN‐Net) based on various objectives. The integration of MobileNet with deep neural network (DNN) forms the MNN‐Net. By employing deep neuro‐fuzzy network (DNFN), the power prediction is done. The efficiency of the developed MNN‐Net is validated with some methods and achieved superior performance with an average waiting time of 11.796 s, distance 0.067 m, available power 53.657 W and number of EVs charged 63.
Advancing health equity: Why guideline development must prioritize fairness and justice
Authors: Dewidar Omar , Pardo Jordi Pardo , Peña‐Rosas Juan Pablo , Thomas Rebecca , Welch Vivian , Tugwell Peter 
Published: January 2025

AbstractHealth equity should be regarded as a fundamental principle and a priority for all guideline development organizations. Yet, this principle has not been consistently prioritized in the creation of mainstream guidelines. In this commentary, we examine a real‐world example from leprosy management, where the initial lack of integration of health equity considerations in the guideline recommendations did not consider the potential impact of the recommendations on the health of populations most affected by leprosy. We also highlight subsequent changes in the guideline development process that reflect stronger consideration of health equity, addressing some of the previous issues propagated with historical practices. We also draw on other examples from several fields to further illustrate the impact of integrating health equity considerations in guidelines. Building on evaluations of guidelines for health equity and real‐world experiences, we highlight some of the common challenges in integrating health equity considerations in the guideline development process. We propose potential solutions using existing tools and frameworks and outlining key research priorities to further advance this goal.
C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS‐STING Pathway
Authors: Wang Yue , Xu Ting , Wang Wenjun 
Published: January 2025

ABSTRACTPurposeC9orf72 deficiency contributes to severe inflammation in mice. Ulcerative colitis (UC) is a chronic inflammatory disorder with the shortage of clinical success. However, whether C9orf72 is involved in the progression of UC is not fully understood. This study investigated whether C9orf72 could alleviate dextran sulfate sodium (DSS)‐induced colitis in mice and lipopolysaccharide (LPS)‐induced colitis in Caco‐2 cells.MethodsMice were injected AAV9‐C9orf72 lentivirus through tail vein and fed 3% DSS for a week. Caco‐2 cells were cultured to establish C9orf723 overexpressed model. Histopathological examination, level of inflammation, cGAS‐STING pathway, and gut barrier function were detected in mice and cells.ResultsC9orf72 overexpression in mice attenuated DSS‐induced colitis and intestinal epithelial barrier damage by stimulating ZO‐1 and Occludin expression. In LPS‐induced Caco‐2 cells, C9orf72 overexpression increased cell viability and the expression of ZO‐1 and Occludin. C9orf72 overexpression alleviated inflammation by inhibiting the cGAS‐STING pathway in colonic tissue and Caco‐2 cells.ConclusionC9orf72 overexpression attenuated DSS‐induced colitis and intestinal epithelial barrier damage by inhibiting the cGAS‐STING pathway. C9orf72 may present a target for mitigating UC.
COLOR OUTPUT GENERATION SYSTEM
Authors: Dinwiddie James H. , Mullens Robert C. 
Published: January 2025

ABSTRACTThe computing industry's development of visual display hardware, including printers, cathode ray devices and plotters has presented a unique problem to the user of such equipments. In addition to being familiar with the idiosyncracies of these display devices, the user must be a capable computer programmer to gather and convert the data to be displayed.The general purpose Color Output Generation System (COGS) is a research vehicle for exploring the future development of general purpose programming languages for display devices. COGS enables the user to quickly specify display equipment and to easily and efficiently specify the acquisition and format of the data to be represented. Scaling, framing and data conversions are handled within the system and need not be considered by the user.COGS can be a highly efficient short cut in the complex field of data representation. Most advanced techniques of graphic representation have been incorporated into the system which has been designed and implemented exclusively by Datatrol Corporation for the National Military Command System Support Center. Displays have been programmed for the NMCSSC full color system and the on‐line printer. It is anticipated that displays for plotters and cathode ray devices can be handled with equal ease.
Scan Converter Tubes And Their Applications
Authors: Nagy G. T. 
Published: January 2025

SummaryThe scan converter tube described in this paper is a special Cathode Ray Tube used for the bright display conversion of air traffic control displays. In recent years, this device was further developed for or several other display systems, for storage, scan conversion and signal integration. The tubes developed by several manufacturers are designed with different target systems and, therefore, different operation principles. The theory of the target systems and operation principles, storage capabilities and properties are discussed. The two major types of tubes, the single and dual gun tube construction and their applications, are described in a form which shows the usefulness and further potential for the future of this device.
Contracting Incentives, XBRL Adoption, and Accounting Conservatism: Empirical Evidence in a European Context
Authors: Dalci Ilhan , Tarzibash Omar Fikrat Fateh , Ozyapici Hasan 
Published: January 2025

ABSTRACTThis study aims to explore how XBRL adoption affects conditional conservatism and moderates the financial leverage and conditional conservatism relationship. Using the financial data between 2000 and 2022 for 332 listed firms in Belgium, Spain, and Denmark, the empirical results, first, demonstrate that financial leverage positively influences conditional conservatism. The results also reveal that XBRL adoption has a negative impact on conditional conservatism and negatively moderates the positive effect of financial leverage on conditional conservatism. The results overall imply that XBRL adoption reduces the impact of contracting incentives on conditional conservatism. In this regard, the results suggest that XBRL adoption substitutes for the contractual role of conditional conservatism. The results contribute to the ongoing discussion regarding the influence of technological developments on financial reporting systems, and they are expected to have important implications for managers, potential investors, creditors, and regulators.
Theoretical Study on Adsorption of Halogenated Benzenes on Montmorillonites Modified With M(I)/M(II) Cations
Authors: Tunega Daniel , Gerzabek Martin H. , Böhm Leonard 
Published: January 2025

ABSTRACTHalogenated benzenes (HBs) are hydrophobic organic chemicals belonging to persistent organic pollutants. Owing to their persistence, they represent a serious problem in environmental contamination, specifically of soils and sediments. One of the most important physical processes determining the fate of HBs in soils is adsorption to main soil components such as soil organic matter and soil minerals. Smectites, layered clay minerals of the 2:1 type, are common minerals in clay‐rich soils, of which montmorillonite (Mt) is a typical representative. This work focuses on a systematic modeling study of the adsorption mechanism of selected HBs interacting with the basal (001) surface, which is the dominant surface of Mt particles. The HB···Mt interactions were studied by means of a quantum chemical approach based on the density functional theory method. HBs were represented by five molecules, particularly C6F6, C6Cl3F3, C6Cl6, C6Br3Cl3, and C6Br6. In mixed HBs (C6Cl3F3 and C6Br3Cl3) Cl atoms are in 1,3,5 or rather 2,4,6 positions. The effect of a different cation type on adsorption was investigated for M+/M2+‐Mt models with cations from alkali group (M+: Li, K, Na, Rb, Cs) and alkaline earth metal group (M2+: Mg, Ca, Sr., Ba). The calculations were also performed on the gas phase HB···M+/M2+ complexes for comparison. Adsorption energies and distances of the main HB molecular plane from the Mt surface were calculated as a measure of the adsorption strength. The results showed that the strongest HB adsorption is for the Na+‐Mt and Ca2+‐Mt surfaces. The strongest affinity was observed for hexabromobenzene, while the weakest adsorption was found for hexafluorobenzene. The decomposition of the adsorption energy showed that its dominant component is dispersion energy and less important is the cation‐π interaction. The calculated adsorption energies showed a good correlation with experimentally determined log Kd values.
Aptamer‐Conjugated Exosomes Ameliorate Diabetes‐Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a‐Mediated Mitochondrial Function
Authors: Song Jia , Yang Mengmeng , Xia Longqing , Wang Liming , Wang Kewei , Xiang Yingyue , Cheng Jun , Chen Jun , Liu Jidong , Zhao Ruxing , Liu Fuqiang , Sun Zheng , Hou Xinguo , Zang Nan , Chen Li 
Published: January 2025

ABSTRACTBackgroundMuscle atrophy is associated with Type 2 diabetes mellitus, which reduces the quality of life and lacks effective treatment strategies. Previously, it was determined that human umbilical cord mesenchymal stromal cell (hucMSC)–derived exosomes (EXOs) ameliorate diabetes‐induced muscle atrophy. However, the systemic application of EXOs is less selective for diseased tissues, which reduces their efficacy and safety associated with their nonspecific biological distribution in vivo. Therefore, improving exosomal targeting is imperative. In this study, a skeletal muscle–specific aptamer (Apt) was used to explore the effects of Apt‐functionalized EXOs derived from hucMSCs in diabetes‐associated muscle atrophy and its specific mechanisms.MethodsDiabetic db/db mice and C2C12 myotubes were used to explore the effects of MSC‐EXOs or Apt‐EXOs in alleviating muscle atrophy. Grip strength, muscle weight and muscle fibre cross‐sectional area (CSA) were used to evaluate skeletal muscle strength and muscle mass. Western blot analysis of muscle atrophy signalling, including MuRF1 and Atrogin 1 and the mitochondrial complex and Seahorse analysis were performed to investigate the underlying mechanisms of MSC‐EXOs or Apt‐EXOs on muscle atrophy.ResultsMSC‐EXOs increased grip strength (p = 0.0002) and muscle mass (p = 0.0044 for tibialis anterior (TA) muscle, p = 0.002 for soleus (SO) muscle) in db/db mice. It also increased the CSA of muscle fibres (p = 0.0011 for all fibres, p = 0.0036 for slow muscle fibres and p = 0.0089 for fast muscle fibres) and the percentage of slow‐to‐fast muscle fibres (p = 0.0109). However, Atrogin 1 (p = 0.0455) and MuRF1 expression (p = 0.0168) was reduced. MSC‐EXOs activated SIRT1/FoxO1/3a signalling and enhanced mitochondrial function in db/db mice and C2C12 myotubes. SIRT1 knockdown decreased the beneficial antiatrophic effects of MSC‐EXOs. Additionally, Apt conjugation increased the effect of MSC‐EXOs on muscle atrophy and myofiber‐type transition (p = 0.0133 for grip strength, p = 0.0124 for TA muscle weight, p = 0.0008 for SO muscle weight, p < 0.0001 for CSA of all muscle fibres, p = 0.0198 for CSA of slow muscle fibres, p = 0.0213 for CSA of fast muscle fibres, p = 0.011 for percentage of slow–fast muscle fibres, p = 0.0141 for Atrogin 1 expression and p = 0.005 for MuRF1 expression).ConclusionsThe results suggest that hucMSC‐derived exosomes ameliorate diabetes‐associated muscle atrophy by enhancing SIRT1/FoxO1/3a‐mediated mitochondrial function and that Apt conjugation strengthens the effects of MSC‐EXOs on muscle atrophy. These findings demonstrate the therapeutic potential of muscle‐targeted MSC‐EXOs for the treatment of muscle atrophy.
The Combined and Isolated Impacts of El Niño and Positive Indian Ocean Dipole Events on South American Precipitation During Austral Winter and Spring Depending on the Atlantic Multidecadal Oscillation Phases
Authors: Souza Itamara P. , Andreoli Rita V. , Kayano Mary T. , Costa Jean A. C. , Mamani Leonardo , Souza Rodrigo A. F. , Cerón Wilmar L. 
Published: January 2025

ABSTRACTThe isolated/combined impacts of the positive Indian Ocean Dipole (pIOD) and El Niño (EN) events on precipitation in South America (SA) were investigated during austral winter and spring for the 1901–2012 period, considering both Atlantic Multidecadal Oscillation (AMO) phases. Under the warm phase (WAMO), EN events are well characterised in winter and, in spring, are accompanied by anomalous warming of the Tropical North Atlantic (TNA); thus, variations in the Walker circulation and the northward shifted Intertropical Convergence Zone (ITCZ) reduce precipitation over northern SA. In the cold AMO phase (CAMO), EN events are weak in winter. At the same time, an intense cooling in the equatorial North Atlantic, favoured by the CAMO, enhances moisture transport from the Amazon to central and southeastern Brazil, increasing precipitation in the South Atlantic Convergence Zone region. As EN develops in spring, the anticyclone off the east coast of SA associated with the Pacific‐South American (PSA) pattern decreases (increases) precipitation in central (southeastern) SA. The pIOD events predominantly occur during WAMO phase, when warming in the TNA is favoured by AMO. In winter, the moisture transport to northern SA is weakened, and the ITCZ remains northward shifted, inhibiting the precipitation over northeastern Brazil and southeastern Amazon. In spring, pIOD intensified ascending motions in equatorial Atlantic, increasing precipitation over northeastern Brazil. A wave train from the Indian Ocean strengthens the South Atlantic subtropical high, suppressing precipitation in central and eastern SA. EN‐pIOD events are well established in both AMO phases, though the sea surface temperature anomalies in the TNA depend on the AMO. During WAMO, reduced precipitation in western Amazon and northeastern SA is influenced by the Walker circulation, while in CAMO, TNA cooling enhances moisture transport from the Amazon into southeastern SA, where the PSA pattern and wave train from the Indian Ocean increase precipitation.