bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular vesicles in ageing cold‐stored whole blood may not compensate for the decreasing haemostatic function in vitro
Authors: Ilvonen Petra , Susila Sanna , Impola Ulla , Pusa Reetta , Helin Tuukka , Joutsi‐Korhonen Lotta , Laitinen Saara , Lauronen Jouni , Ilmakunnas Minna 
Published: January 2025

AbstractBackgroundExtracellular vesicles (EVs) have procoagulative properties. As EVs are known to accumulate in stored blood products, we compared the EV content and coagulation capacity of leukoreduced cold‐stored whole blood (CSWB) with current prehospital and in‐hospital component therapies to understand the role of EVs in the haemostatic capacity of ageing CSWB.Materials and MethodsBlood was obtained from 12 O RhD‐positive male donors. CSWB was compared with in‐hospital component therapy of red blood cells (RBCs), OctaplasLG and buffy‐coat platelets and prehospital component therapy of RBC and lyophilized plasma. Samples were drawn on Days 1 and 14 of CSWB and RBC cold storage. Blood count, haemolysis markers, rotational thromboelastometry, sonorheometry and thrombin generation were analysed. EVs were analysed using nanoparticle tracking analysis and cellular origin was determined using imaging flow cytometry.ResultsThere was a trend towards increased production of both platelet and RBC‐derived EVs during CSWB storage. Particle count increased during storage, whereas thrombin generation slowed down and in viscoelastic assays, clotting times prolonged, clot formation became impaired, and stiffness of the resulting clot decreased.ConclusionBoth platelet and RBC‐derived EVs increased in number in CSWB during storage. This did not appear to compensate for the in vitro decreasing haemostatic capacity of ageing CSWB, suggesting EVs produced during storage may not have active procoagulative effects, but rather reflect the ageing of blood cells.
Alloanti‐Hy in antenatal patients: A multi‐case review
Authors: Lewis S. , Kirkpatrick N. , Nawrocki A. , Reyland L. , Jones B. , Laundy R. , McNeil A. , Crew V. Karamatic , Stutt T. , Clinton D. , Anbazhagan A. , Harris C. , Skidmore I. , Bullock T. , Hazell M. 
Published: January 2025

AbstractIntroductionIntroduction The Hy antigen is one of ten red cell antigens belonging to the Dombrock blood group system, with an antigen frequency of almost 100% in the majority of populations. Alloantibodies to high prevalence antigens cause difficulties with antibody identification and exclusion in serological investigations.Case PresentationThis review describes the management of four antenatal cases where the presence of alloanti‐Hy had been identified. Hy‐red blood cell units may be required for the transfusion of patients with alloanti‐Hy, but currently, there are no published reports of alloanti‐Hy causing haemolytic disease of the fetus and newborn (HDFN). A previous case report involving the care and management of antenatal patients with alloanti‐Hy antibodies indicates a lack of evidence that alloanti‐Hy causes clinical HDFN.ResultsAll cases discussed in this review demonstrate a reduction in the strength of alloanti‐Hy levels as pregnancy progressed. Signs or symptoms of HDFN were not observed with any of the pregnancies.ConclusionFactors such as antibody levels, antigenic expression, and varying clinical responses enhance our understanding of why alloanti‐Hy has not been known to cause clinical HDFN. The cases presented here aim to improve understanding of alloanti‐Hy in pregnancy and how to manage such cases.
Comparison of conventional coagulation tests and ROTEM in identifying trauma‐induced coagulopathy for massive haemorrhage protocol activation
Authors: Hutspardol Sakara , Borja Tyrone , Kroeker Jenna , Wang Xiu Qing , Mi Jian , Zamar David , Chan Geoffrey , Smith Tyler , Hawes Harvey , Shih Andrew W. 
Published: January 2025

AbstractObjectivesTrauma‐induced coagulopathy (TIC) can be fatal but preventable if recognised early. With emerging uses of rotational thromboelastometry (ROTEM) to guide transfusions in trauma, patient outcomes with TIC‐defined by initial ROTEM and conventional coagulation tests (CCTs) during massive haemorrhage protocol (MHP) activations were evaluated at a primary trauma centre in British Columbia.MethodsThis retrospective observational study included adult trauma patients requiring MHP from June 1, 2020, to May 31, 2022. TIC, defined by initial results including (1) ROTEM‐based EXTEM A10 <40 mm, EXTEM CT >100 s, EXTEM ML30 >10%, FIBTEM A10 <10 mm; and (2) CCT‐based INR ≥1.8, PTT ≥1.5 times of upper normal limit, platelets <50 x 109/L, and Clauss Fibrinogen <1.5 g/L, was assessed for its correlation with mortality. Modified Poisson regression was used to model 28‐day mortality.ResultsTwenty‐two of sixty‐eight patients (32%) had abnormal ROTEM but normal CCTs. TIC defined by CCTs was associated with increased mortality [24 h: 5/13 (38%) vs. 5/55 (9%), p = 0.025; 28d: 8/13 (62%) vs. 11/55 (20%), p = 0.002]; compared to ROTEM, which was not [24 h: 7/35 (20%) vs. 3/33 (9%), p = 0.307; 28d: 11/35 (31%) vs. 9/33 (27%), p = 0.594], despite requiring significantly higher blood component transfusion within the first 4 and 24 h of MHP (p‐values<0.05).ConclusionsROTEM is more sensitive in identifying TIC. Patients with abnormal CCTs had a higher death rate, and those with abnormal ROTEM had no significantly increased mortality. A prospective study is required to assess the effects of ROTEM further.
An international survey of patient blood management practices
Authors: Gammon Richard , Jindal Aikaj , Dubey Rounak , Shipp Cathy , Tayal Amit , Rajbhandary Srijana , Bocquet Christopher 
Published: January 2025

AbstractBackgroundThe Association for the Advancement of Blood and Biotherapies (AABB) conducted a global survey of patient blood management (PBM) practices. It determined changes in PBM practices since the last survey.Study Design and MethodsA working group of AABB's PBM Subsection and AABB staff designed the survey using the Qualtrics™ platform. The survey collected data from January 1, 2021, through December 31, 2021, and data analysis was conducted.ResultsResponses were received from 274 facilities across five World Health Organization (WHO) regions, from which 205 (74.8%) were from North America (NA), and 25.2% (69/274) were from outside of NA or the rest of the world (RoW). Of all respondents, 46.0% (126/274) had a PBM program. NA at 50.2% (103/205) was significantly higher than RoW at 33.3% (23/69) (p = .0049). In NA AABB transfusion guidelines, 36.8% (179/486) were the most followed versus RoW, with the Ministry of Health at 23.2% (29/125). The hemoglobin transfusion threshold of ≤7.0 g/dL (inpatients and outpatients) and platelet transfusion threshold of 5000/μL −10,000/μL (prophylaxis for inpatients and outpatients) were most commonly followed. Areas of improvement since the last AABB 2013 survey included providing PBM training increased to 61.7% (103/167) from 36.5% (219/600) and evaluation of patients undergoing elective surgical procedures for factors predictive of anemia to 46.0% (125/272) from 28% (144/507).ConclusionsWhile gains have been made in certain areas of PBM, there remains room for improvement, as more than half of respondents did not have a PBM program.
A Case of Prostatic Lymphoma in a Dog with Symptoms of a Uroperitoneum Evaluated with Ultrasonography and Fluoroscopy
Authors: Seshadri Ashika , Thevelein Britt , Huber Brian Thomas , Perlini Michael 
Published: January 2025

ABSTRACTA 10‐year‐old neutered male Labrador mix dog presented with a few‐day history of stranguria and dysuria. Results of physical examination, laboratory findings, and imaging were consistent with a uroperitoneum and prostatomegaly. Ultrasound showed an enlarged, heterogeneous, and lobular prostate with mineralization, and fluoroscopy showed extravasation of contrast from the prostatic urethra through the prostatic parenchyma into the abdomen. The dog was diagnosed with prostatic lymphoma via cytology and ultimately euthanized. This is the first report of prostatic lymphoma with a concurrent uroperitoneum due to urine leakage from the prostatic urethra through the prostatic parenchyma and capsule into the abdomen.
Implementation of Conventional and Smart Weed Management Strategies in Sustainable Agricultural Production
Authors: Xuan Tran Dang , Khanh Tran Dang , Minh Tran Thi Ngoc 
Published: January 2025

ABSTRACTConventional weed management is known for the use of selective herbicides, tackling issues of herbicide‐resistant weeds, and endeavors to reduce reliance on herbicides, such as employing biological control of weeds and incorporating allelopathy. These strategies are integrated with traditional and other conventional weed management techniques. New challenges in agricultural production, such as declining population involved in agriculture, global warming, and climate changes make conventional weed management inadequate. Rapid advancements over the past decade in artificial intelligence (AI), unmanned aerial vehicles (UAVs), cameras, and sensors, necessitate the development and implementation of smart weed management (SWM) approaches for the 21st century. Wise weed management practices can control weeds and reduce emissions of methane (CH4), carbon dioxide (CO2), and nitrogen dioxide (NO2). Minimizing the use of herbicides in tandem with the application of smart technologies, like weed mapping and identifying spatial variability of weeds using proximal and remote sensors, multispectral and RGB cameras, can effectively manage weeds while also reducing labor costs. The SWM strategies also encompass the integrated use of organic herbicides, bioherbicidal products, and the judicious application of both organic fertilizers and inorganic fertilizers for weed management. Some approaches, such as alternate wetting and drying (AWD), can contribute to both SWM and carbon credits to farmers. The utilization of computing power, weed control robotics, and big data, combined with the education of the next generation of weed scientists and efforts to shift growers' attitudes and behaviors in weed management, may vary among countries. It requires active collaboration between agricultural extensionists and policymakers.
EXPERIMENTAL STUDY ON NOTCH SHAPE AND LIQUID CARBONITRIDING SPECIMENS UNDER BENDING LOADING
Authors: H. Nasser Sajjad , Shakir Dumoaa Haider 
Published: January 2025

The current work includes studying the effect of heat treatment using liquid carbon nitriding technology on steel notched (Mechanical testing is part of the process; include tests for surface microhardness, fatigue before and after treatment,tensile testing and chemical analysis of the material. Before treatments, fatigue testing was done on the notched specimens at room temperature under full reverse bending stress. Obusirved that V-notching the specimen reduced strength and fatigue life of steel. The results showed that heat treatments significantly increased strength and fatigue life; in comparison to untreated samples, heat treatments increased fatigue life by 12.5% and 20%, respectively. Finding that the carbonitriding method of hardening produced a surface hardness of 868.71HV, which was 73% higher than the non-hardened samples.The fatigue strength increased to 338.55 MPa and 455.56 MPa at 30° and 90 °, respectively, at the highest temperature due to saturation of the surface with carbon and nitrogen atoms.
How do socioeconomic inequalities and preterm birth interact to modify health and education outcomes? A narrative systematic review
Authors: McHale Philip , Fahy Katie , Pennington Andy , Schlüter Daniela K , Barr Ben , Taylor-Robinson David 
Published: January 2025

ObjectivesHow are socioeconomic inequalities modified by, or how do they interact with, preterm birth?DesignNarrative systematic review of quantitative observational studies of an interaction, or effect modification, between preterm birth and socioeconomic status.Data sourcesFive databases were searched for studies published between January 2000 and June 2020. Title and abstract were reviewed to identify articles for dual screening. All included studies were citation searched.Eligibility criteriaInclusion criteria were comparison across socioeconomic status and gestational age, interaction between the two, or stratification by either, and health or education as outcome.Data extraction and synthesisData extracted included study design, sample size, outcome, interaction measure, effect and significance. Included studies were assessed for methodological quality and synthesised narratively.ResultsAfter searches, 52 studies were identified for full-text screening and, with supplementary citation searches, we identified 21 included studies. Eighteen studies studied interaction between gestational age or preterm birth, and socioeconomic status. Three groups of outcomes were identified: cognitive, mental health and developmental. Age at outcome measurement was divided into four categories: preschool, primary school (5–11), secondary school (11–18) and post school (18–29). Seven studies found a significant interaction between the effect of preterm birth and socioeconomic status. Six of these interactions demonstrate that the negative influence of low socioeconomic status was stronger for those born preterm (and vice versa) for cognitive and mental health outcomes, all in studies with a sample size of more than 100 000. One study found that negative effects of low socioeconomic status were reduced for those born preterm (and vice versa) for communication delay.ConclusionsOur findings suggest that the impact of low socioeconomic status on cognitive and mental health outcomes is exacerbated by preterm birth. The remaining evidence suggests the effects are not modified; however, this is potentially due to underpowered studies. Public health action is indicated to support babies born preterm, particularly for disadvantaged families, to improve educational attainment and mental health.PROSPERO registration numberCRD42020203613.
Protocol for a systematic review and individual participant data meta-analysis for risk factors for lung cancer in individuals with lung nodules identified by low-dose CT screening
Authors: Alexandris Panos , Quaife Samantha , Berg Christine D , Callister Matthew , Crosbie Philip AJ , Davies Michael PA , de Koning Harry J , Field John K , Hammer Mark M , Horst Carolyn , Janes Sam , Nair Arjun , Rintoul Robert C , Gabe Rhian , Duffy Stephen 
Published: January 2025

BackgroundWorldwide, lung cancer (LC) is the second most frequent cancer and the leading cause of cancer related mortality. Low-dose CT (LDCT) screening reduced LC mortality by 20–24% in randomised trials of high-risk populations. A significant proportion of those screened have nodules detected that are found to be benign. Consequently, many individuals receive extra imaging and/or unnecessary procedures, which can have a negative physical and psychological impact, as well as placing a financial burden on health systems. Therefore, there is a need to identify individuals who need no interval CT between screening rounds.Methods and analysisThe aim of this study is to identify risk factors predictive of LC, which are known at the time of the scan, in patients with LDCT screen-detected lung nodules. The MEDLINE and EMBASE databases will be searched and articles that are on cohorts or mention cohorts of screenees with nodules will be identified. A data extraction framework will ensure consistent extraction across studies. Individual participant data (IPD) will be collected to perform a one-stage IPD meta-analysis using hierarchical univariate models. Clustering will be accounted for by having separate intercept terms for each cohort. Where IPD is not available, the effects of risk factors will be extracted from publications, if possible. Effects from IPD cohorts and aggregate data will be reported and compared. The PROBAST (Prediction model Risk Of Bias ASsessment Tool) will be used for assessment of quality of the studies.Ethics and disseminationEthical approval was not required as this study is a secondary analysis. The results will be disseminated through publication in peer-reviewed journals and presentations at relevant conferences.PROSPERO registration numberCRD42022309515
Path analysis of factors influencing length of stay and hospitalisation expenses for oral cancer patients in tertiary hospitals in southeastern China: a cross-sectional study
Authors: Fan Yi , Yang Qiujiao , Chen Chen , Hu Xiaoying , Xu Mingming , Weng Yanfeng , Li Yanni , Wang Yaping , Lin Lisong , Qiu Yu , Wang Jing , Chen Fa , He Baochang , Liu Fengqiong 
Published: January 2025

AimsTo investigate the associations between influencing factors with length of stay (LOS) and hospitalisation expenses in oral cancer (OC) patients, and to explore the potential pathways through which these factors influence hospitalisation expenses using path analysis.DesignCross-sectional.SettingA comprehensive tertiary hospital in southeastern China.ParticipantsA total of 810 patients with histologically confirmed primary OC admitted to the First Affiliated Hospital of Fujian Medical University, Fujian Province, between 2015 and 2020.Main outcome measuresLOS and hospitalisation expenses for OC patients.ResultsThe median hospitalisation expenses and LOS for OC patients in southeastern China were substantial, amounting to $6330 and 29 days, respectively. Treatment and surgery fees constituted the largest proportion of total expenses (28.59%), followed by inspection and laboratory test fees (20.63%), comprehensive medical service fees (19.27%), drug fees (18.09%) and medical consumables fees (11.69%). LOS was significantly associated with tumour site, surgery and chemotherapy. Factors such as longer LOS, poor oral hygiene, advanced tumour stage (II–IV), larger tumour size (>2 cm3), surgery and bilateral neck dissection were strongly linked to higher hospitalisation expenses. Path analysis revealed that neck dissection had the highest total effect on hospitalisation expenses (β=0.307), while surgery exerted an indirect effect on expenses via LOS (β=0.021).ConclusionThis study highlights the significant economic burden imposed by OC on patients and healthcare systems. While prevention and early diagnosis remain critical, our findings underscore several modifiable factors, including improving oral hygiene and optimising surgical protocols, such as chemotherapy and lymph node dissection, that present opportunities to reduce costs and enhance cost-effectiveness. These insights provide actionable targets for mitigating financial burdens and improving patient outcomes.
Exploratory study of patients’ and carers’ preferences for postdischarge surgical wound monitoring using survey and interviews
Authors: Tanner Judith , Brierley Jones Lyn , Westwood Nigel , Rochon Melissa , Wloch Catherine , Rogers Luke J , Vaja Ricky , Dearling Jeremy , Wilson Keith , Harrington Pauline , Brown Colin S , Murphy Gavin 
Published: January 2025

ObjectivesTo explore patients’ and carers’ preferences for postdischarge surgical wound monitoring.DesignExplanatory mixed methods study with an online survey followed by online interviews.SettingThe online survey was distributed via the Cardiothoracic Interdisciplinary Research Network and cardiac surgery patient and public involvement groups in London and Leicester, UK. Participants were invited to share the survey link with other patients and carers. Interviewees were recruited through the survey.ParticipantsSeventy participants completed the survey: 74% patients and 26% carers. A range of ages, sex, ethnicities and geographical locations were represented. Six survey patient participants volunteered to be interviewed.FindingsThemes identified were the impact on patients of having a surgical site infection, patients’ preferences for postdischarge surgical wound follow-up, access to specialist support, wound monitoring using digital technology and receiving information from the hospital about wounds and wound care. Interviewees described feeling isolated after discharge from hospital and 10% of survey patient respondents, including four of the six interviewees, reported hospital readmissions. Survey respondents’ preferred routes for providing hospitals with wound information were over the telephone (30%), emails (24%), text messages (16%) and photos sent securely (14%). All six interviewees’ preference was for digital approaches using images. Survey respondents were least likely (50%) to reply to questionnaires that required software to be downloaded and installed. Interviewees considered digital wound monitoring to be convenient and the best use of patient and staff resources. A new theme was identified where patients wanted to become more involved in treating their surgical wounds at home.ConclusionExperiences described by participants suggests there is a need to improve post-discharge wound monitoring. A new approach should be proactive, ongoing and provide easy access to healthcare services. Digital surgical wound monitoring offers these benefits and is acceptable to patients.Trial registration numberISRCTN13950775; Post-results.
How can cervical screening meet the needs of vulnerable women? A qualitative comparative study with stakeholder perspectives from seven European countries
Authors: Bøje Rikke Buus , Bardou Marc , Mensah Keitly , Rico Berrocal Raquel , Bonvicini Laura , Iorio Giusy , Auzzi Noemi , Taut Diana , Pașca Nicoleta-Monica , Tisler Anna , Reintamm Kerli , Uusküla Anneli , Teixeira Margarida , Firmino-Machado João , Amorim Mariana , Baia Ines , Lunet Nuno , Panayotova Yulia , Kotzeva Tatyana , Todorova Irina , Andersen Berit , Kirkegaard Pia 
Published: January 2025

ObjectiveThis study explored and compared stakeholder perspectives on enhancements to cervical cancer screening for vulnerable women across seven European countries.DesignIn a series of Collaborative User Boards, stakeholders were invited to collaborate on identifying facilitators to improve cervical cancer screening.SettingThis study was part of the CBIG-SCREEN project which is funded by the European Union and targets disparities in cervical cancer screening for vulnerable women (www.cbig-screen.eu). Data collection took place in Bulgaria, Denmark, Estonia, France, Italy, Portugal and Romania.ParticipantsRepresented stakeholders at various levels, including user representatives (vulnerable women), healthcare professionals, social workers, programme managers and decision makers.Methods14 meetings lasting 2 hours each were held in these seven countries between October 2021 and June 2022. The meetings were audio or video recorded, transcribed and translated into English for qualitative framework analysis.ResultsWe engaged 120 participants in the Collaborative User Boards. Proposed solutions targeted both provider and system levels. In all countries, fostering trusting relationships between vulnerable women and social or healthcare professionals, coupled with community outreach for awareness and access to testing was a consistent recommendation. Participants in Estonia, Denmark, France, Italy, Portugal and Romania advocated for tailoring healthcare services to meet the unique needs of vulnerable populations through a holistic approach. In Bulgaria and Romania, participants advocated for the need to secure free access, from screening to follow-up, and emphasised the need for organised screening with target population screening registries.ConclusionThe study offers insights into stakeholders' recommendations for enhancing cervical cancer screening services for vulnerable women across seven European countries. Despite variations in the implementation level of population-based screening programmes, the imperative to optimise outreach and proximity work to improve cervical cancer screening resonated across all countries.