bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful desensitization in a patient with recurrent anaplastic oligodendroglioma presenting with procarbazine-mediated anaphylaxis
Authors: Kayikçi Hazal , Can Bostan Özge , Tuncay Gülseren , Cihanbeylerden Melek , Tüccar Çise , Damadoglu Ebru , Karakaya Gül , Kalyoncu Ali Fuat 
Published: January 2024

Introduction Procarbazine is an oral chemotherapeutic agent used in the treatment of brain malignancies and is associated with hypersensitivity reactions. In case of grade 4 reactions, rechallenge should be avoided, and the agent should be replaced, unless the treatment is curative, in which case the application of a desensitization protocol should be considered. We present a successful case of desensitization in procarbazine anaphylaxis. Case report A 53-year-old male patient was diagnosed with recurrent anaplastic oligodendroglioblastoma. The patient received three cycles of procarbazine, lomustine, and vincristine chemotherapy for malignancy recurrence. In the fourth cycle, on the 12th day of procarbazine treatment, the patient developed anaphylaxis. Procarbazine was given together with premedication as part of the 12-step desensitization process, and the fourth cycle was successfully completed. Management and outcome Procarbazine hypersensitivity reactions are observed less frequently than reactions to other chemotherapeutics. We presented a case of procarbazine-associated severe anaphylaxis that was able to continue procarbazine chemotherapy with successful desensitization. This case is important in terms of confirming the procarbazine desensitization protocol. Discussion In literature there is only one protocol developed was successfully applied in one patient with procarbazine anaphylaxis. In the current case, we took this protocol into consideration in the management of our patient. Following the use of this protocol, the patient was able to continue procarbazine chemotherapy successfully. Procarbazine anaphylaxis is rare, and more cases are needed to be reported to confirm the desensitization protocol and when to continue procarbazine treatment.
The absence of antibodies in longitudinally extensive transverse myelitis may predict a more favourable prognosis
Authors: Rocchi Chiara , Forcadela Mirasol , Kelly Patricia , Linaker Samantha , Gibbons Emily , Bhojak Maneesh , Jacob Anu , Hamid Shahd , Huda Saif 
Published: January 2024

Background: Isolated first episodes of longitudinally extensive transverse myelitis (LETM) have typically been associated with neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, in some cases, serological testing and screening for other aetiologies are negative, a condition referred to as double seronegative longitudinally extensive transverse myelitis (dsLETM). Objective: The objective of this study was to evaluate comparative outcomes of dsLETM, MOGAD-LETM and NMOSD-LETM. Methods: Cohort study of LETM cases seen in the UK NMOSD Highly Specialised Service between January 2008 and March 2022. Results: LETM = 87 cases were identified (median onset age = 46 years (15–85); median follow-up = 46 months (1–144); 47% NMOSD-LETM = 41 (aquaporin-4 antibodies (AQP4-IgG) positive = 36), 20% MOGAD-LETM = 17 and 33% dsLETM = 29). Despite similar Expanded Disability Status Scale (EDSS) at nadir, last EDSS was higher in AQP4-IgG and seronegative NMOSD-LETM (sNMOSD) ( p = 0.006). Relapses were less common in dsLETM compared to AQP4-IgG NMOSD-LETM and sNMOSD-LETM (19% vs 60% vs 100%; p = 0.001). Poor prognosis could be predicted by AQP4-IgG (odds ratio (OR) = 38.86 (95% confidence interval (CI) = 1.36–1112.86); p = 0.03) and EDSS 3 months after onset (OR = 65.85 (95% CI = 3.65–1188.60); p = 0.005). Conclusion: dsLETM remains clinically challenging and difficult to classify with existing nosological terminology. Despite a similar EDSS at nadir, patients with dsLETM relapsed less and had a better long-term prognosis than NMOSD-LETM.
Use of pragmatic randomized trials in multiple sclerosis: A systematic overview
Authors: Hirt Julian , Janiaud Perrine , Düblin Pascal , Nicoletti Giovanni Jacopo , Dembowska Kinga , Nguyen Thao Vy Thi , Woelfle Tim , Axfors Cathrine , Yaldizli Özgür , Granziera Cristina , Kuhle Jens , Kappos Ludwig , Hemkens Lars G 
Published: January 2024

Background: Pragmatic trials are increasingly recognized for providing real-world evidence on treatment choices. Objective: The objective of this study is to investigate the use and characteristics of pragmatic trials in multiple sclerosis (MS). Methods: Systematic literature search and analysis of pragmatic trials on any intervention published up to 2022. The assessment of pragmatism with PRECIS-2 (PRagmatic Explanatory Continuum Indicator Summary-2) is performed. Results: We identified 48 pragmatic trials published 1967–2022 that included a median of 82 participants (interquartile range (IQR) = 42–160) to assess typically supportive care interventions ( n = 41; 85%). Only seven trials assessed drugs (15%). Only three trials (6%) included >500 participants. Trials were mostly from the United Kingdom ( n = 18; 38%), Italy ( n = 6; 13%), the United States and Denmark (each n = 5; 10%). Primary outcomes were diverse, for example, quality-of-life, physical functioning, or disease activity. Only 1 trial (2%) used routinely collected data for outcome ascertainment. No trial was very pragmatic in all design aspects, but 14 trials (29%) were widely pragmatic (i.e. PRECIS-2 score ⩾ 4/5 in all domains). Conclusion: Only few and mostly small pragmatic trials exist in MS which rarely assess drugs. Despite the widely available routine data infrastructures, very few trials utilize them. There is an urgent need to leverage the potential of this pioneering study design to provide useful randomized real-world evidence.
Virtual agents among participants with methamphetamine use disorders: Acceptability and usability study
Authors: Li Shuo , Wang Yue , Chen Liyu , Chen Tianzhen , Du Jiang , Su Hang , Jiang Haifeng , Wu Qianying , Zhang Lei , Bao Jiayi , Zhao Min 
Published: January 2024

Introduction While the potential future role of virtual agents (VAs) in treating addiction is promising, participants’ attitudes toward the use of VAs in psychotherapy remain insufficiently investigated. This lack of investigation could pose barriers to the adoption of VA-led psychotherapy for people with substance use disorders (SUD). This research aims to explore the acceptability and usability of VAs for people with methamphetamine use disorder. Methods Following a single session of psychotherapy led by VAs through the Echo-app, a group of 49 individuals actively seeking treatment for current DSM-V substance dependence (with a mean age of 39.06 ± 8.02) completed self-administered questionnaires and participated in focus group interviews. These questionnaires aimed to investigate participants’ preference regarding the type of psychotherapy and their willingness to engage in VA-led psychotherapy, taking into account their diverse psychological needs. Results Quantitative data were subjected to analysis through both descriptive and inferential statistical methods. Interestingly, participants exhibited a significantly higher acceptability for traditional face-to-face psychotherapy compared to email-based psychotherapy ( p = 0.042), but there was no statistically significant difference between their acceptance of traditional psychotherapy and VA-led psychotherapy ( p = 0.059). The questionnaire outcomes indicated participants’ willingness to engage in VA-led psychotherapy for purposes such as relapse prevention intervention, addressing emotional issues, managing somatic experiences, and facilitating social and family functional recovery. Furthermore, the participants’ attitudes toward VA-led psychotherapy were predicted by factors including the need for anxiety-focused psychotherapy ( p = 0.027; OR [95%CI] = 0.14[0.03,0.80]), the presence of chronic somatic diseases ( p = 0.017; OR [95%CI] = 13.58[1.59,116.03]), and marital status ( p = 0.031; OR [95%CI] = 5.02[1.16,21.79]). Discussion Through the interviews, the study uncovered the factors that either supported or hindered participants’ experiences with VA-led psychotherapy, while also gathering suggestions for future improvements. This research highlights the willingness and practicality of individuals with SUD in embracing VA-led psychotherapy. The findings are anticipated to contribute to the refinement of VA-led tools to better align with the preferences and needs of the users.
The association between post-injury chronic physical health conditions, health status, and survival time in people with serious orthopaedic injuries
Authors: Gelaw Asmare Yitayeh , Gabbe Belinda J , Arnup Sarah J , Reeder Sandra , Fitzgerald Mark , Lyons Ronan Anthony , Ponsford Jennie Louise , Collie Alex , Christie Nicola , Nunn Andrew , Harrison James E , Cameron Peter , Ekegren Christina L 
Published: January 2024

Background A better understanding of how chronic physical health conditions affect long-term outcomes following injury is essential for quantifying the burden of serious orthopaedic injuries. We aimed to describe the association between the presence of post-injury chronic physical health conditions and (i) the change in health status from before injury to six different follow-up time points after injury; and (ii) survival time. Methods A cohort study was conducted using linked data from the REcovery after Serious Trauma: Outcomes, Resource Use, and Patient Experiences study, the Victorian Registry of Births, Deaths and Marriages (BDM) (2009–2017), the victorian admitted episodes dataset (2009–2017) and the victorian emergency minimum dataset (2009–2017). Adults (≥ 18 years old) with serious orthopaedic injuries who survived to discharge from their trauma admission were included. Multivariable linear regression analysis was conducted to evaluate the association between post-injury chronic physical health conditions and the mean change in health status (EuroQol-Visual Analogue Scale) from before injury to six follow-up time points post-injury. Survival analysis was conducted to estimate the probability of survival for people with and without chronic physical health conditions following injury. Results Out of 894 participants, 177 (19.8%) had at least one chronic physical health condition recorded up to five years post-injury. People with post-injury conditions reported a greater mean decline in health status than people without post-injury conditions (difference, (95% CI): −6.9 (−9.7, −4.2), p = 0.01). Over the study period, almost six times as many people with chronic physical health conditions post-injury died as people without these conditions (AHR (95% CI): 5.7 (2.9, 11.3), p < 0.01). Conclusions Chronic physical conditions after serious orthopaedic injuries were associated with a lower survival probability and a deteriorating health status. Orthopaedic injury survivors may benefit from early detection and treatment of chronic conditions.
Protection of unaccompanied child and adolescent migrants in Catalonia: Inhabited places, occupied places or non-places?
Authors: Vilà Baños Ruth , Sánchez-Martí Angelina , Freixa Niella Montserrat , Venceslao Pueyo Marta 
Published: January 2024

Summary In response to the so-called “refugee crisis,” the Catalan regional government set up experimental services for children migrating without guardians, with the explicit aim of safeguarding their rights. With their continued arrival, however, overcrowding in the facilities and the youths’ educational and life prospects have become topics of fierce debate. This article investigates whether young migrants can live in the educational centers that host them. Basing ourselves on the distinction between occupying and living in a place, we call into question the conditions of non-life that, from the educational perspective, the reception system offers migrant youth. A qualitative study was undertaken to gather and triangulate the views of the young migrants ( n = 42), and that of their social educators ( n = 15), and of the management of the reception centers ( n = 2). Findings Despite efforts to put in place policies affording quality attention, a series of contradictions cause the system to favor the homogenization of outcomes rather than adequately acknowledging and addressing the youths’ individual needs. This added to the lack of resources mobilized, has yielded the result that the system that supposedly provides protection for minors, rather than being a lived-in place, has become a classical example of a non-occupied space. Applications Providing a habitable place depends on the pedagogical commitment of social educators and managers to offering these children the chance to build emotional ties with the center, so that it may become a proper place in the world despite the bureaucratic and structural hurdles.
‘You have to let them do it themselves’: Analyzing professional support in a befriending project
Authors: Naessens Liesbeth , Dury Sarah , Raeymaeckers Peter 
Published: January 2024

Summary In Western welfare states, public and non-profit service organizations are increasingly looking for ways to combine the efforts and expertise of professionals and volunteers to provide support and services to vulnerable target groups. However, little is known about how professionals and volunteers collaborate to provide these social services and support. The aim of this qualitative study is to analyze how professionals support volunteers in a befriending project, where volunteers provide support to people after they are released from prison. Therefore, we interviewed social workers (n = 4) and volunteers (n = 13). Findings Our results show that professionals provide tailor-made support to volunteers through different interventions: they share their knowledge and expertise, provide emotional support, and advise and coach the volunteers. Furthermore, in complex cases, professionals intervene to access appropriate social support and realize the rights of those involved. Applications Our findings provide a comprehensive perspective on how complementarity is constructed in the daily practice of collaboration between volunteers and professionals. Although professional interventions and support are necessary to address the needs of vulnerable people, volunteers offer a wider range of support than professionals alone can provide. Consequently, close collaboration between volunteers and professionals can result in a valuable response to the needs of people who have recently left prison. However, when a client's situation becomes complex and volunteers lack the skills, experience, and status to deal with it, professionals are advised to take over.
Preparation of intercalated hydrotalcite materials and its effect on thermal stability properties of polyvinyl chloride
Authors: Du Guifang , Duan Jinsheng , Jia Peijie , Liu Zhaogang , Feng Fushan , Hu Yanhong , Wu Jinxiu , Zhang Xiaowei , Li Jianfei 
Published: January 2024

In this study, ZnAlLa-maleate-LDHs was synthesized using the co-precipitation-hydrothermal method. The effects of aluminum-lanthanum ratio, co-precipitation time, hydrothermal time, and hydrothermal temperature on the crystal structure were investigated. As indicated by the result, the optimal condition was n (Al3+): n (La3+) = 10:1, the co-precipitation time reached 24 h, the hydrothermal time was 8 h, and the hydrothermal temperature reached 180°C. The effect of hydrotalcite on the thermal stability properties and plasticizing properties of PVC was analyzed. The result suggested that ZnAlLa-maleate-LDHs enhanced the thermal stability, plasticizing properties, and mechanical properties of PVC compared with ZnAlLa-CO3-LDHs. The layer spacing of hydrotalcite was increased with the introduction of maleic acid, such that the entry of Cl− into the interlayer guest was facilitated, and the decomposition of PVC was inhibited. Moreover, the long-term thermal stability mechanism was analyzed using FTIR before and after hydrochloric acid treatment. As revealed by the above result, the thermal stabilizer ZnAlLa-maleate-LDHs are capable of hindering the breakage of C-Cl bonds in PVC, inhibiting the formation of HCl, and playing a certain role in thermal stabilization.
Effect of False Lumen Occlusion Treatment With AFX VELATM, Candy-Plug Technique for Chronic Aortic Dissection
Authors: Yasuhara Kiyomitsu , Obayashi Tamiyuki , Ohki Satoshi , Okonogi Shuichi , Nagasawa Ayako , Yamaguchi Ryo , Kato Yusuke , Miki Takao , Abe Tomonobu 
Published: January 2024

Introduction We sought to examine midterm results and remodeling effect of false-lumen occlusion treatment using AFX VELA in case of chronic dissection repair. Material and Methods From June 2019 to May 2022, we performed false lumen occlusion treatment using a modified Candy-Plug technique with AFX VELA on 8 chronic aortic dissection patients with a patent false lumen. We collected operative data, short-term clinical outcomes, mid-term clinical outcomes and imaging test results. We conducted follow-up examinations at postoperative, 6-month and 1-, 2- and 3-year intervals, including contrast-enhanced computed tomography to evaluate the diameter, false lumen thrombosis and any events. Results The average time from the symptom onset to the thoracic endovascular repair was 81.5 (35-155) months. The aorta showed aneurysmal dilation with an average maximum short-axis diameter of 58.9 (41-91) mm. Two cases needed emergency surgery due to rupture and impending rupture. There were no postoperative deaths. Complete thrombosis within the false lumen was achieved in 6 cases (75%), but 2 cases had incomplete thrombosis, requiring additional treatment. The mean maximum diameter showed a significant decrease at 6 months, 1 year and 2 years postoperatively compared to preoperative measurements ( P < .05). Conclusion We showed the results of false lumen occlusion treatment using the AFX VELA cuff. We observed favorable clinical outcomes and remodeling effects. While the long-term durability and efficacy of this technique in aortic remodeling will need to be monitored with further observation, the use of this cuff is considered a reliable approach to false lumen occlusion treatment.
The Computational Interaction Analyses of Some Vitamin D-Related Compounds with Sterol 14-Demethylase (CYP51) – Could It Be a Glimmer of Hope to Find New Anti-Mucormycotic Drugs Extracted from Plants-Derived Sterols?
Authors: Faris Shalayel Mohammed Helmy , Al-Mazaideh Ghassab M. , Almutairi Majed Meshal , Alsubhi Wael A. , Althaiban Abdullah K. 
Published: January 2024

Introduction Many vitamin D analogs and sterols-related compounds have been identified and extracted from several plants including Solanaceae species. The aim of our study was to evaluate the antifungal potential of 15 vitamin D, D3 analogs, and some sterols-related compounds that have been detected in some plants along with 3 standard antifungal drugs, Isavuconazole, Fluconazole, and Voriconazole, on the Mucormycosis-sterol 14-alpha demethylase (CYP51) enzyme by in silico study. Methods In this work, the molecular simulation was used to prepare the specific enzyme and the antifungal profiles utilized for the molecular docking of the contemplated compounds and subsequent prediction for the mechanism of binding within the catalytic site of Sterol 14-Demethylase (CYP51) to speculate their binding affinities. Anti-fungal medications, Fluconazole and Voriconazole revealed drugs bound distant from the binding sites, but Isavuconazole bound close to the binding site. In this context, the 15 vitamin D and D3 compounds were somewhat seen in binding proximity, especially for Alfacalcidol, Eldecalcitol, and Inecalcitol. Results Seocalcitol and Isavuconazole had the lowest binding energies and were the closest ones connected to the binding cavities with the best binding free energies equal −13.21 ± 0.24 and −15.29 ± 0.25, respectively. Conclusion Isavuconazole and Seocalcitol could potentially be further assessed to be adjuvantly used as drugs to inhibit the fungal activity by targeting CYP51, a significant target for anti-fungal as well as anti-protozoan drugs, and hence could be efficient against mucormycosis.
Navigating the asthma network on Twitter: Insights from social network and sentiment analysis
Authors: Pratiwi Hening , Benkő Ria , Kusuma Ikhwan Yuda 
Published: January 2024

Background Asthma is a condition in which the airways become inflamed and constricted, causing breathing difficulties, wheezing, coughing, and chest tightness. Social networks can have a substantial effect on asthma management and results. However, no studies of social networks addressing asthma have been undertaken. Objective The aim of this research was to identify the significant social network structures, key influencers, top topics, and sentiments of asthma-related Twitter conversations. Methods All the tweets collected for this study included the keyword “asthma” or were mentioned in or in replies to tweets that were performed. For this study, a random sample of Twitter data was collected using NodeXL Pro software between December 1, 2022, and January 29, 2023. The data collected includes the user's display name, Twitter handle, tweet text, and the tweet's publishing date and time. After being imported into the Gephi application, the NodeXL data were then shown using the Fruchterman-Reingold layout method. In our study, SNA (Social Network Analysis) metrics were utilized to identify the most popular subject using hashtags, sentiment-related phrases (positive, negative, or neutral), and top influencer by centrality measures (degree, betweenness). Results The study collected 48,122 tweets containing the keyword “asthma” or mentioned in replies. News reporters and journalists emerged as top influencers based on centrality measures in Twitter conversations about asthma, followed by government and healthcare institutions. Education, trigger factors (e.g., cat exposure, diet), and associated conditions were highly discussed topics on asthma-related social media posts (e.g., sarscov2, copd). Our study's sentiment analysis revealed that there were 8427 phrases associated neutral comments (18%), 12,582 words reflecting positive viewpoints (26%), and 27,111 words reflecting negative opinions (56%). Conclusion This study investigates the relevance of social media influencers, news reporters, health experts, health organizations, and the government in the dissemination and promotion of asthma-related education and awareness during public health information.
Time Series Data Analysis of Mindfulness Breathing Method Using Electroencephalogram
Authors: Togo Eiichi 
Published: January 2024

Introduction Workers and students are often stressed and distressed by a variety of factors, including work and study. However, support for individual psychological stress is not yet well established. Objective This study aimed to evaluate the effect of mindfulness breathing on the mental load of college students using an electroencephalogram (EEG). Methods Twenty participants were randomly allocated into treatment or control groups, with 10 participants in each group. Mindfulness breathing was applied to participants in the treatment group, while those in the control group received no treatment. The regression equation was evaluated from the EEG, and time series analysis was performed based on autocorrelation and partial autocorrelation. Results In the After condition after mindfulness breathing exercises in the Mi group, the alpha wave content of the regression equation at eye closure after task performance showed an upward trend, and the autocorrelation coefficient showed repeated upward and downward fluctuations. Conclusion It was suggested that alpha wave content may increase over time with mindfulness breathing exercises. The EEG after mindfulness breathing exercises was shown not to be constant and to have non-linear characteristics. This suggested that the effects of mindfulness breathing exercises could be evaluated using time series data.