bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Fast Decliner of Diabetic Kidney Disease Using Chiral Amino Acid Profiling: A Pilot Study
Authors: Hirakawa Yosuke , Kimura Tomonori , Sakai Shinsuke , Mizui Masayuki , Mita Masashi , Isaka Yoshitaka , Nangaku Masaomi , Inagi Reiko 
Published: January 2025

ABSTRACTBiomarkers for the prediction of diabetic kidney disease are still unsatisfactory. Although D‐amino acids have been shown to reflect kidney conditions, their efficacy in treating diabetic kidney disease (DKD) has not been demonstrated. This study explored the potential role of D‐amino acids as progression markers for DKD, an aspect not addressed previously. We performed comprehensive D‐amino acid measurements and collected the longitudinal estimated glomerular filtration rate (eGFR) data of 135 patients. We defined fast decliners (FDs) as patients exhibiting >10% decline from baseline eGFR per year and compared the D‐amino acid levels of FDs and non‐FDs. Then, we verified that D‐amino acids could predict FDs independent of creatinine levels. In patients with diabetic kidney disease, D‐serine, D‐alanine, and D‐proline were only detected in the blood, while 15 D‐amino acids were detected in the urine. Using supervised orthogonal partial least squares analysis, blood D‐serine and urine D‐amino acid levels were identified as features characterizing diabetic kidney disease. Baseline blood D‐serine levels and ratios did not differ between the FD and non‐FD groups; however, short‐term changes in blood D‐serine levels differed. This study emphasized the significance of D‐serine as a prognostic marker for DKD, an aspect not identified in previous research.
Balloon Dilation Technique Influences Stent Shortening and Intentional Stent Fracture During Overexpansion of Drug‐Eluting Stents: A Bench‐Testing Study
Authors: Gupta Mudit , Leeth Ella B. , Barak‐Corren Yuval , Gartenberg Ari J. , Silvestro Elizabeth , O'Byrne Michael L. , Callahan Ryan 
Published: January 2025

ABSTRACTBackground and AimsDrug‐eluting stents (DES) are not designed for overexpansion to supra‐nominal diameters or intentional stent fracture (ISF). The optimal dilation technique to minimize stent shortening (SS) and achieve ISF to accommodate pediatric somatic growth has not been described.MethodsThree sizes of two commonly used DES were implanted within a silicone model to simulate blood vessels. Each stent was serially dilated in 1 mm increments under fluoroscopy using three techniques: 2 cm length, semi‐compliant balloons (Technique 1), 2 cm, noncompliant balloons straddling the entire stent (Technique 2), or noncompliant balloons in an “inside‐out” manner (balloon shorter than stent or 2 cm balloon aligned with distal end of stent (no straddle); (Technique 3). Technique 1 crossed over to noncompliant balloons once stent “napkin‐ringed” (NR). Percent SS = (Lnominal – Lfinal)/Lnominal * 100.ResultsTechnique 1 resulted in the greatest SS (median 85%, IQR 82, 87) and universal napkin ringing. Technique 2 caused less SS (median 14%, IQR 7, 15), and Technique 3 caused the least SS (median 7%, IQR 3, 11). ISF was achieved in all, however, the inside–out technique caused ISF at smaller stent diameters (median 114% recommended postdilation limit vs. 122%–131%) and lower inflation pressures (median 15 vs. 28–29 ATM). ISF was achieved in Technique 1 after napkin ringing but required larger noncompliant balloons than other techniques (median 8.5 vs. 7 mm).ConclusionInside–out dilation resulted in less SS and fracture at smaller diameters with lower inflation pressures. This technique may improve the ISF success rate of DES in pediatric patients.
Presacral Lipoblastoma Presenting With Urinary Retention
Authors: Abera Michael Teklehaimanot , Abdo Isa Salo , Damtew Henok Dessalegn , Yaynishet Yodit Abraham , Abdela Abubeker Fedlu , Mohammed Hidaya Yahya , Zewdie Atiklet Zerihun , Waktola Misiker Gebremariam , Hailu Samuel Sisay , Bonger Mulugeta Temesgen 
Published: January 2025

ABSTRACTLipoblastoma is a rare fatty tumor that can uncommonly arise in the presacral space. When the lesions attain sufficient size, they can cause a multitude of infiltrative and obstructive symptoms. In this report, we present the case of a 1‐year‐old infant who presented with recurrent urinary retention for 4 months due to a large presacral lipoblastoma, which was successfully resected. This case is unique as it highlights the lesion's rare location in the presacral space and the possibility of such lesions presenting with urinary retention.
Electrocatalytic Reduction of CO2 to Long‐Chain Hydrocarbons: Investigating the Asymmetric C−C Coupling Mechanism on Pd3Au Catalysts
Authors: Zheng Ming , Lv Chade , Zhou Xin 
Published: January 2025

AbstractThe electrochemical reduction of CO2 to high‐energy‐density hydrocarbons is pivotal for addressing energy and environmental challenges. Understanding the mechanisms underlying the conversion of CO2 to long‐chain hydrocarbons is both crucial and complex. In this study, we employed density functional theory (DFT) calculations to investigate the C−C coupling mechanisms responsible for the formation of C2‐C4 products on Pd3Au catalysts. Our findings highlight the sequential formation of C2−C1 bonds via asymmetric C−C coupling as a critical pathway for generating C3 product, which is essential for controlling product selectivity. Detailed analysis of coupling reactions involving CCH2* and CCH3* intermediates with various C1 species indicates that these asymmetric coupling events are energetically favorable and play a decisive role in the selective assembly of carbon atoms into longer hydrocarbon chains. Moreover, we propose a mechanism wherein the asymmetric coupling of C1‐C3 intermediate leads to a diverse array of C4 products. This process underscores the importance of CH2 group coupling with C3 intermediates in forming long‐chain hydrocarbons. Our work provides valuable insights into optimizing catalyst design for improved selectivity towards higher hydrocarbons in CO2 reduction processes.
Efficient Blue Electroluminescence Based on a Donor‐π‐Acceptor with Pyrene Bridge: Weak Charge‐Transfer (CT) for High Luminescence and Considerable Exciton Utilization
Authors: Yao Mingming , Men Shuyi , Yu Kuo , Wei Jinbei , Zhang Shi‐Tong , Yang Bing 
Published: January 2025

AbstractBlue emitters are crucial in the organic light emitting diode (OLED) industry and scientific field. In this work, we prepared a novel donor‐π‐acceptor (D‐π‐A) molecular PCZ−P‐PY using pyrene as a bridge to construct hybrid local and charge‐transfer (HLCT) state with weak charge‐transfer (CT) property. This excited state design give rise to the high photoluminescent quantum yield (PLQY), more importantly, it is also responsible for the high exciton utilization efficiency (EUE) by constructing efficient hot‐exciton channel. As a result, exceeding external quantum efficiency (EQE) of 5.7 % is achieved in the non‐doped OLED of PCZ−P‐PY with exceeding EUE of up to 90 %.
Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group
Authors: Chaidali Andriani G. , Terzidis Michael A. , Lykakis Ioannis N. 
Published: January 2025

AbstractCyclopropane derivatives serve as important building blocks in organic synthesis, due to their three‐membered stretched ring. Nitro‐substituted cyclopropanes (NCPs) represent a special class of donor‐acceptor cyclopropanes (DACs) that contain a strong electron‐withdrawing nitro group as substituent on the cyclopropyl moiety. Due to the versatile nature of the nitro group, which can be converted into other functional azo groups or heterocyclic scaffolds, NCPs are considered important building blocks in the design of complex organic compounds. Herein, the present review is organized in two main sections focused on the synthesis and application of NCPs. The part containing the synthetic methodologies of NCPs has been further divided into distinct sections based mainly on the nature of the starting materials, such as: a) from nitroalkenes, b) from nitro‐bearing diazo compounds, c) from nitroalkanes in combination with alkenes, d) from aminocyclopropanes under oxidative conditions, and e) from various nitro compounds, through miscellaneous processes. In the part concerning the applications and use of NCPs, the categorization includes three main subcategories, concerning their reduction to 1‐aminocyclopropane‐1‐carboxylic acids (ACC), the ring opening of NCPs leading to valuable open‐chain heterocycles, and the ring expansion to larger cyclic and heterocyclic compounds.
Helicene–Fluorescein Hybrids: A Reversible Base‐Triggered (Chir)optical Switch with Sign Inversion of Circularly Polarized Luminescence
Authors: Miwa Sorachi , Mizutani Daichi , Kawano Kenichi , Matsuzaki Katsumi , Nagata Yuuya , Tsubaki Kazunori , Takasu Kiyosei , Takikawa Hiroshi 
Published: January 2025

AbstractNovel circularly‐polarized‐luminescence (CPL) materials were designed and synthesized by integrating the intrinsic chirality of helicene with the acid/base‐responsive properties of fluorescein. The synthesized helicene–fluorescein hybrids exhibit reversible switching between blue fluorescence under neutral conditions and red fluorescence under basic conditions. Furthermore, these hybrid compounds demonstrate unique chiroptical switching behavior with a rare base‐triggered CPL sign inversion, where (P)‐isomers show a negative CPL signal around 450 nm under neutral conditions and a positive signal around 620 nm under basic conditions, with three‐fold enhanced dissymmetry factors (|glum|) under basic conditions. The structural basis for this switching was elucidated through TD‐DFT calculations, revealing distinct angles between magnetic and electric transition dipole moments in closed versus open forms. Live‐cell imaging experiments using HeLa cells revealed that the hybrid compounds exhibit intracellular red emission with minimal cytotoxicity, thus promising potential as chiral fluorescent probes for biological applications.
Lamellarin D Acts as an Inhibitor of Type I Collagen Production
Authors: Okuno Daisuke , Sakamoto Noriho , Hayashi Hideki , Fukuda Tsutomu , Akiyama Yoshiko , Iketani Chiaki , Murakami Ritsuko , Tokito Takatomo , Miyamura Takuto , Yura Hirokazu , Kido Takashi , Ishimoto Hiroshi , Takemoto Shinnosuke , Takazono Takahiro , Nishino Tomoya , Ishimatsu Yuji , Ishihara Jun , Takeda Kohsuke , Tanaka Yoshimasa , Mukae Hiroshi 
Published: January 2025

AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive and chronic interstitial lung disease characterized by irreversible loss of lung function and a poor prognosis. Type I collagen, a major component of the extracellular matrix, plays a central role in the pathogenesis of fibrosis and is considered a key molecular target for therapeutic intervention. While current anti‐fibrotic therapies demonstrate limited efficacy in slowing disease progression, their clinical impact remains suboptimal due to poor pharmacokinetic properties and non‐curative therapy. Moreover, the development of effective anti‐fibrotic agents targeting collagen synthesis is hindered by the absence of robust, cost‐effective, high‐throughput drug screening platforms. In this study, we established a novel screening system designed to identify small molecules that inhibit the expression of the COL1A2 gene, which encodes type I collagen. Utilizing this system, we screened a library of natural and synthetic compounds developed at Nagasaki University and identified lamellarin D as a potent inhibitor of COL1A2 expression and subsequent type I collagen production. These findings suggest that lamellarin D, through its unique molecular mechanism, may serve as the foundation for the development of a new class of IPF treatments aimed at targeting the underlying fibrotic processes.
Integrating UAV‐based multispectral remote sensing and machine learning for detection and classification of chocolate spot disease in faba bean
Authors: Mohammadi Shirin , Uhlen Anne Kjersti , Aamot Heidi Udnes , Dieseth Jon Arne , Shafiee Sahameh 
Published: January 2025

AbstractChocolate spot (CS), caused by Botrytis fabae, is one of the most destructive fungal diseases affecting faba bean (Vicia faba L.) globally. This study evaluated 33 faba bean cultivars across two locations and over 2 years to assess genetic resistance and the effect of fungicide application on CS progression. The utility of unmanned aerial vehicle–mounted multispectral camera for disease monitoring was examined. Significant variability was observed in cultivar susceptibility, with Bolivia exhibiting the highest level of resistance and Louhi, Sampo, Vire, Merlin, Mistral, and GL Sunrise proving highly susceptible. Fungicide application significantly reduced CS severity and improved yield. Analysis of canopy spectral signatures revealed the near‐infrared and red edge bands, along with enhanced vegetation index (EVI) and soil adjusted vegetation index, as most sensitive to CS infection, and they had a strong negative correlation with CS severity ranging from −0.51 to −0.71. In addition, EVI enabled early disease detection in the field. Support vector machine accurately classified CS severity into four classes (resistant, moderately resistant, moderately susceptible, and susceptible) based on spectral data with higher accuracy after the onset of disease compared to later in the season (accuracy 0.75–0.90). This research underscores the value of integrating resistant germplasm, sound agronomic practices, and spectral monitoring for effectively identification and managing CS disease in faba bean.
Impact of sleep disruptions on gray matter structural covariance networks across the Alzheimer's disease continuum
Authors: Luo Xiao , Li Kaicheng , Zeng Qingze , Liu Xiaocao , Li Jixuan , Zhang Xinyi , Zhong Siyan , Liu Lingyun , Wang Shuyue , Wang Chao , Chen Yanxing , Zhang Minming , Huang Peiyu ,   for the Alzheimer's Disease Neuroimaging Initiative (ADNI)
Published: January 2025

AbstractBACKGROUNDThis study explores the impact of sleep disturbances on gray matter structural covariance networks (SCNs) across the Alzheimer's disease (AD) continuum.METHODSAmyloid‐negative participants served as controls, whereas amyloid positive (A+) individuals were categorized into six groups based on cognitive status and sleep quality. SCNs for the default mode network (DMN), salience network (SN), and executive control network (ECN) were derived from T1‐weighted magnetic resonance images.RESULTSIn the DMN, increased structural associations were observed in cognitive unimpaired (CU) A+ and mild cognitive impairment (MCI) groups regardless of sleep quality, whereas AD with poor sleep (PS) showed a decrease and AD with normal sleep (NS) an increase. For the ECN, AD‐NS showed increased and AD‐PS showed reduced associations. In the SN, reduced associations were observed in CU A+ NS and MCI‐NS, whereas AD‐NS displayed increased associations; only AD‐PS had decreased associations.CONCLUSIONDistinct SCN damage patterns between normal and poor sleepers provide insights into sleep disturbances in AD.Highlights
We delineated distinct patterns of structural covariance networks (SCN) impairment across the Alzheimer's disease (AD) continuum, uncovering significant disparities between individuals with normal sleep architecture and those afflicted by sleep disturbances.
These observations underscore the pivotal importance of addressing sleep disruptions in AD therapeutics, providing a refined understanding of their detrimental impact on brain networks implicated in the disease.
Our investigation epitomizes methodological precision by constructing an AD continuum using amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers to minimize diagnostic heterogeneity, further enhanced by a substantial cohort size that bolsters the robustness and generalizability of our findings.
TR(Acking) Individuals Down: Exploring the Effect of Temporal Resolution in Resting‐State Functional MRI Fingerprinting
Authors: Cassone Barbara , Saviola Francesca , Tambalo Stefano , Amico Enrico , Hübner Sebastian , Sarubbo Silvio , Van De Ville Dimitri , Jovicich Jorge 
Published: January 2025

ABSTRACTFunctional brain fingerprinting has emerged as an influential tool to quantify reliability in neuroimaging studies and to identify cognitive biomarkers in both healthy and clinical populations. Recent studies have revealed that brain fingerprints reside in the timescale‐specific functional connectivity of particular brain regions. However, the impact of the acquisition's temporal resolution on fingerprinting remains unclear. In this study, we examine for the first time the reliability of functional fingerprinting derived from resting‐state functional MRI (rs‐fMRI) with different whole‐brain temporal resolutions (TR = 0.5, 0.7, 1, 2, and 3 s) in a cohort of 20 healthy volunteers. Our findings indicate that subject identifiability within a fixed TR is successful across different temporal resolutions, with the highest identifiability observed at TR 0.5 and 3 s (TR(s)/identifiability(%): 0.5/64; 0.7/47; 1/44; 2/44; 3/56). We discuss this observation in terms of protocol‐specific effects of physiological noise aliasing. We further show that, irrespective of TR, associative brain areas make an higher contribution to subject identifiability (functional connections with highest mean ICC: within subcortical network [SUB; ICC = 0.0387], within default mode network [DMN; ICC = 0.0058]; between DMN and somato‐motor [SM] network [ICC = 0.0013]; between ventral attention network [VA] and DMN [ICC = 0.0008]; between VA and SM [ICC = 0.0007]), whereas sensory‐motor regions become more influential when integrating data from different TRs (functional connections with highest mean ICC: within fronto‐parietal network [ICC = 0.382], within dorsal attention network [DA; ICC = 0.373]; within SUB [ICC = 0.367]; between visual network [VIS] and DA [ICC = 0.362]; within VIS [ICC = 0.358]). We conclude that functional connectivity fingerprinting derived from rs‐fMRI holds significant potential for multicentric studies also employing protocols with different temporal resolutions. However, it remains crucial to consider fMRI signal's sampling rate differences in subject identifiability between data samples, in order to improve reliability and generalizability of both whole‐brain and specific functional networks' results. These findings contribute to a better understanding of the practical application of functional connectivity fingerprinting, and its implications for future neuroimaging research.
Stage‐specific characterization of “early‐onset colorectal cancer”: Localized and synchronous metastatic disease
Authors: Akkus Erman , Karaoğlan Beliz Bahar , Kayaalp Mehmet , Turmuş Utkucan , Akyol Cihangir , Utkan Güngör 
Published: January 2025

AbstractEarly‐onset colorectal cancer (EOCRC) is an alarming entity worldwide. Yet, stage‐specific characteristics and prognosis in localized and synchronous metastatic EOCRC are not well‐defined. Two cohorts of CRC patients (localized and synchronous metastatic) were evaluated, defining EOCRC as the diagnosis <50 years old. Five hundred sixty‐eight patients were included (n = 432 localized, 14.4% [n = 62] EOCRC and n = 136 synchronous metastatic, 20.6% [n = 28] EOCRC). 93.5% of localized and 96.5% of synchronous metastatic EOCRC patients were symptomatic at diagnosis. Among localized patients, female gender (58.1% vs. 40%, p = .008), perineural invasion (41.9% vs. 24.9%, p = .005), folinic acid, 5‐fluorouracil, and oxaliplatin chemotherapy (45.2% vs. 25.2%, p = .003), and perioperative chemotherapy cycles (9.21 [± 3.10] vs. 7.98 [± 2.92], p = .006) were higher in EOCRC compared with ≥50‐year. Median recurrence‐free survival (RFS) and overall survival were not reached in either group (p = .234 and p = .831). Only RAS mutant status was associated with RFS (Hazard ratio: 7.09 [95% confidence interval (CI): 1.87–26.76], p < .001) in EOCRC. Among synchronous metastatic patients, urgent surgery (32.1% vs. 11.1%, p = .014) and local treatments (39.3% vs. 20.4%, p = .037) were more frequent in EOCRC. Median progression‐free survival and overall survival in the EOCRC and ≥50 years were 8.07 months (95% CI: 5.03–12.97) vs. 10.03 months (95% CI, 8.40–13.10) (p = .450) and 18.57 months (95% CI, 13.33–43.03) vs. 19.83 months (95% CI, 16.07–27.30) (p = .833), respectively. Synchronous metastatic EOCRC more frequently underwent urgent surgery (32.1% vs. 8%, p = .008) and had RAS mutation (43.5% vs. 16.7%, p = .032) than localized EOCRC. This study suggests that localized and synchronous metastatic EOCRC patients may have different characteristics than average onset, without survival differences. Implementation of stage‐specific characteristics into daily practice is necessary for decision‐making processes in these young patients.
Evaluation of plasma alpha‐1‐antichymotrypsin as a marker for pulmonary Kaposi sarcoma
Authors: Nalwoga Angela , Jackson Conner , Fiorillo Suzanne , Manyeruke Felix , Makoni Tobias , Nyagura Tatenda , White Irene E. , Rapaport Eric , Rochford Rosemary , Borok Margaret , Campbell Thomas B. 
Published: January 2025

AbstractIndividuals with AIDS and Kaposi sarcoma (AIDS‐KS) with pulmonary involvement have high‐risk of poor outcomes but diagnosis of pulmonary KS in low‐resource settings is difficult. We aimed to discover plasma proteins that distinguish individuals with pulmonary KS from those without pulmonary involvement. SomaScan proteomics screen measured 7288 plasma proteins in 22 cases and 17 controls selected from 181 participants with HIV‐1 and cutaneous KS who underwent bronchoscopy. Cases had KS in the lower respiratory tract by bronchoscopy. Controls had no KS lesions detected by bronchoscopy. Results of the proteomics screen were confirmed by ELISA measurement of plasma alpha‐1‐antichymotrypsin (SERPINA3) in 18 cases and 13 controls and in an additional 162 individuals with AIDS‐KS who were not included in the case–control analysis. Proteomics identified 12 plasma proteins with differential levels in controls and cases. Plasma alpha‐1‐antichymotrypsin (SERPINA3) complex was consistently higher in cases compared to controls in the proteomics assay. Measurement of plasma alpha‐1‐antichymotrypsin by ELISA confirmed higher levels in cases (median 399.4, IQR 95.77–766.4 μg/ml) versus controls (median 39.98, IQR 31.2–170.2 μg/ml; p = .001). Plasma alpha‐1‐antichymotrypsin correlated with the estimated burden of pulmonary KS in the respiratory tract (r = 0.439; p = .0002) and 234 μg/ml had 51% sensitivity and 94% specificity for detection of pulmonary KS by bronchoscopy. Measurement of plasma alpha‐1‐antichymotrypsin has potential for identifying persons with pulmonary AIDS‐KS and estimating the burden of KS in the lower respiratory tract.