bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic literature review of the human papillomavirus prevalence in locally and regionally advanced and recurrent/metastatic head and neck cancers through the last decade: The “ALARM” study
Authors: Agelaki Sofia , Boukovinas Ioannis , Athanasiadis Ilias , Trimis Georgios , Dimitriadis Ioannis , Poughias Lazaros , Morais Edith , Sabale Ugne , Bencina Goran , Athanasopoulos Charalampos 
Published: January 2024

AbstractAimsThe aim of this systematic literature review was to provide updated information on human papillomavirus (HPV) prevalence in locally and regionally advanced (LA) and recurrent/metastatic (RM) head and neck cancer (HNC) worldwide.MethodsElectronic searches were conducted on clinicaltrials.gov, MEDLINE/PubMed, Embase, and ASCO/ESMO journals of congresses for interventional studies (IS; Phase I–III trials) as well as MEDLINE and Embase for non‐interventional studies (NIS) of LA/RM HNC published between January 01, 2010 and December 31, 2020. Criteria for study selection included: availability of HPV prevalence data for LA/RM HNC patients, patient enrollment from January 01, 2010 onward, and oropharyngeal cancer (OPC) included among HNC types. HPV prevalence per study was calculated as proportion of HPV+ over total number of enrolled patients. For overall HPV prevalence across studies, mean of reported HPV prevalence rates across studies and pooled estimate (sum of all HPV+ patients over sum of all patients enrolled) were assessed.ResultsEighty‐one studies (62 IS; 19 NIS) were included, representing 9607 LA/RM HNC cases, with an overall mean (pooled) HPV prevalence of 32.6% (25.1%). HPV prevalence was 44.7% (44.0%) in LA and 24.3% (18.6%) in RM. Among 2714 LA/RM OPC patients from 52 studies with available data, mean (pooled) value was 55.8% (50.7%). The majority of data were derived from Northern America and Europe, with overall HPV prevalence of 46.0% (42.1%) and 24.7% (25.3%) across studies conducted exclusively in these geographic regions, respectively (Northern Europe: 31.9% [63.1%]). A “p16‐based” assay was the most frequently reported HPV detection methodology (58.0%).ConclusionOver the last decade, at least one quarter of LA/RM HNC and half of OPC cases studied in IS and NIS were HPV+. This alarming burden is consistent with a potential implication of HPV in the pathogenesis of at least a subgroup of HNC, underscoring the relevance of HPV testing and prophylaxis to HNC prevention and management.
Proximate and fatty acid compositions oft en wild‐caught and farmed fish species in mato grosso state, brazil
Authors: Mariotto Sandra , Moriely Ramos Prado Railine , Nascimento Edgar , Rodrigues de Souza Xisto , de Abreu Sousa Demétrio 
Published: January 2024

AbstractThis study analyzed ten fish species (three farmed and seven wild‐caught) to determine their centesimal composition (assessed by AOAC methods) and lipid profile (analyzed by GC‐MS). Notably, “tambatinga” (farmed) and “piraputanga” (wild‐caught) stood out with 28.66 % and 26.44 % protein content and 2.32 % and 3.71 % lipid content, respectively. Across all species, oleic acid was the predominant fatty acid, followed by linoleic acid. The sum of PUFAs ranged from 17.84 % in “matrinchã” to 7.85 % in “piraputanga”. SFA varied from 49.93 % in “tambacu” to 39.90 % in “matrinchã”, while MUFAs ranged from 44.34 % in “palmito” to 38.39 % in “tambaqui”. “Matrinchã” had the highest average ω6 acid content (16.83 %), while “cachara” had the highest average for ω3 acids (5.73 %). “Piraputanga”. “cachara”, and “pincachara” exhibited the lowest ω6 levels. The analysis shows that fish have excellent nutritional values (proximate compositions) with few differences between species. “Pacu”, “matrinchã”, and “cachara” (wild‐caught) demonstrated positive attributes, while “pincachara” (farmed) exhibited the highest nutritional quality in terms of fatty acid fraction. Based on quality indices (H/H), “pacu”, “matrinchã” and “pincachara” are recommended choices for a healthy diet. This study adds valuable insights into the nutritional composition of fish species, which is essential for promoting regional development and local aquaculture.
Two New Isocoumarins Isolated from the Marine‐Sponge‐Derived Fungus Setosphaeria sp. SCSIO41009
Authors: Pang Xiaoyan , Yang Bin , Zhou Xuefeng , Wang Junfeng , Yang Jie , Liu Yonghong 
Published: January 2024

AbstractTwo new dihydroisocoumarins, exserolides L and M (1 and 2), along with six known compounds (3–8) were isolated from the extract of the marine‐sponge‐derived fungus Setosphaeria sp. SCSIO41009. Their structures were established by spectroscopic analyses. The absolute configurations of two new compounds were determined by modified Mosher's method and ECD data. Compounds 1 and 4 showed significant antiviral activities against A/Puerto Rico/8/34 H274Y (H1 N1) with IC50 values of 4.07±0.76 μM and 20.06±4.85 μM, respectively.
Mechanism of crack formation in corn during microwave drying process
Authors: Sun Tongsheng , Cao Ran , Liu Jiahao , Wang Kai 
Published: January 2024

AbstractBackground and ObjectivesDuring microwave drying process of corn, temperature and moisture content are the main reasons for crack formation, which reduces the drying quality. Therefore, it is necessary to study the effects of temperature and moisture content on crack generation.FindingsUnder the set drying conditions, as the temperature increases, cracks gradually increase, deformation gradually increases, and the crack index increases exponentially. As the moisture content decreases, deformation first increases and then decreases, single cracks first increase and then decrease and then increase, double cracks gradually decrease, multiple cracks continue to increase, and the crack index increases linearly. The deformation reaches its maximum value at a moisture content of 31%.ConclusionsThe results indicate that the generation of cracks is mainly influenced by water content. The maximum errors between the simulated and experimental values of temperature and moisture content are 4.73% and 7.76%, respectively, indicating that the model can be used to study the distribution patterns of temperature, moisture content, and deformation during corn drying.Significance and NoveltyThis study established a mathematical model for electromagnetic, mass, energy, and deformation of corn, coupled the model for the solution, and conducted experimental verification. The relationship between the generation of cracks during microwave drying of corn kernels and temperature and moisture content was revealed.
Air‐Stable Manganese NNS Pincer Complexes Enable Ketone Reduction at Room Temperature
Authors: Both Niklas F. , Fessler Johannes , Vicenzi Andrea , Andres Katja , Spannenberg Anke , Junge Kathrin , Beller Matthias 
Published: January 2024

AbstractA series of air‐stable Mn complexes bearing NNS pincer ligands have been synthesized and fully characterized. The activity of the complexes as (transfer) hydrogenation catalysts was investigated in detail, and a variety of ketones (>20 examples) were converted to the corresponding secondary alcohols at room temperature. The synthetic applicability of this class of catalysts is demonstrated by the tolerance of several functional groups including halides, primary amines, nitriles, esters, and nitro‐groups. Moreover, the optimal catalytic system 5c displayed a high chemoselectivity in the presence of other reducible groups such as nitriles, esters, and alkynes. Competitive catalytic experiments with the analogous bidentate NN complex 8 indicated decoordination of the hemilabile thioether‐moiety during formation of the catalytically active hydrido species.
Probing the Electrochemical Processes of Niobium Pentoxides (Nb2O5) for High‐Rate Lithium‐ion Batteries: A Review
Authors: Lin Jie , Zhao Siyu , Jervis Rhodri , Shearing Paul 
Published: January 2024

AbstractThe rising demand to electrify power‐intensive energy devices and systems, as well as fast charging, has imposed a great challenge in current chemistries for lithium‐ion batteries (LIBs), whose rate capabilities are predominantly restricted by the conventional graphite anode. Niobium pentoxide (Nb2O5) is a promising high‐rate anode material for LIBs with extraordinary rate performance beyond 5 C and good theoretical capacity (~202 mAh ⋅ g−1). With many possible crystal structures, Nb2O5 has a complicated family of different polymorphs, each of which can possess distinct electrochemical properties, specific capacity, cycling stability, and rate capability. This special feature of Nb2O5 makes it a challenging material to understand and requires a comprehensive investigation of every one of its polymorphs. In this paper, we summarize the state‐of‐the‐art research on Nb2O5 polymorphs for LIBs, with an emphasis on the advanced characterisation techniques that have been used to probe the electrochemical processes of Nb2O5. Key findings related to Nb2O5 that have emerged from the previous studies are highlighted, and new scientific questions that are important for its scale‐up and commercialization are proposed for future research.
New Insights into Fundamental Processes and Physical Degradation Mechanisms in Rechargeable Lithium‐Oxygen Batteries Providing Suitably High Energy Densities
Authors: Matsuda Shoichi 
Published: January 2024

AbstractLithium‐oxygen batteries (LOBs) can exhibit high energy densities and so have attracted much attention as next‐generation energy storage devices. Although 500 Wh/kg LOBs have recently been demonstrated, the performance of these batteries could still be greatly improved. This Concept article highlights the importance of exploring new technologies, such as gas‐diffusion layers and lightweight protective membranes for lithium metal electrodes, as an approach to realizing LOBs having energy densities sufficient for practical applications. In addition, the physical degradation phenomenon specific to LOBs designed with high energy density is also introduced, such as the volume change of the positive electrode and the movement of the electrolyte associated with the progress of repeated discharge/charge cycles. We believe that the topics presented in this article will promote new research directions in the future development of high energy density and long cycle life LOB.
Investigation of the properties of ZrC nanopowder synthesized by the carbothermal reduction method using phenolic resin
Authors: Rad Farhad Farhang , Mashhadi Mehri , Arateh Kianoosh Akbari 
Published: January 2024

AbstractOwing to economic reasons and the morphology of the surface of particles, carbothermal reduction is a suitable method for the synthesis of the desired materials. In this research, ZrC nanopowder was synthesized using phenolic resin as the carbon source and ZrO2 powder as the source of zinc by the carbothermal method. ZrO2 powder was milled for 1, 2, 3, 4, 6, and 7 h followed by combining with phenolic resin and ethanol with stoichiometric and nonstoichiometric ratios, and then the samples were pyrolyzed for 60 min at 800°C. Then, the samples were heat treated in an argon atmosphere in two stages at 1,600°C for 60 and 90 min. XRD and FE‐SEM were used to investigate the microstructure of the samples. By increasing the molar ratio and increasing the heat treatment time, the ZrC phase content in the samples increased so that the highest amount of ZrC phase was observed in the samples with the carbon to zirconium ratios of 1:6 and 1:9 and the holding time of 90 min. By increasing the heat treatment time, the average size of ZrC particles increased from 130 to 180 nm and the size of crystallites increased from 36 to 46 nm.
Recent progress on mechanisms, principles, and strategies for high‐activity and high‐stability non‐PGM fuel cell catalyst design
Authors: Yuan Yuping , Zheng Yun , Luo Dan , Qiu Weibin , Wang Jiantao , Wang Xin , Chen Zhongwei 
Published: January 2024

AbstractThe commercialization of a polymer membrane H2–O2 fuel cell and its widespread use call for the development of cost‐effective oxygen reduction reaction (ORR) nonplatinum group metal (NPGM) catalysts. Nevertheless, to meet the requests for the real‐world fuel cell application and replacing platinum catalysts, it still needs to address some challenges for NPGM catalysts regarding the sluggish ORR kinetics in the cathode and their poor durability in acidic environment. In response to these issues, numerous efforts have been made to study NPGM catalysts both theoretically and experimentally, developed these into the atomically dispersed coordinated metal–nitrogen–carbon (M–N–C) form over the past decades. In this review, we present a comprehensive summary of recent advancements on NPGM catalysts with high activity and durability. Catalyst design strategies in terms of optimizing active‐site density and enhancing catalyst stability against demetalization and carbon corrosion are highlighted. It is also emphasized the importance of understanding the mechanisms and principles behind those strategies through a combination of theoretical modeling and experimental work. Especially, further understanding the mechanisms related to the active‐site structure and the formation process of the single‐atom active site under pyrolysis conditions is critical for active‐site engineering. Optimizing the active‐site distance is the basic principle for improving catalyst activity through increasing the catalyst active‐site density. Theoretical studies for the catalyst deactivation mechanism and modeling stable active‐site structures provide both mechanisms and principles to improve the NPGM catalyst durability. Finally, currently remained challenges and perspectives in the future on designing high‐performance atomically dispersed NPGM catalysts toward fuel cell application are discussed.
Micelle‐Promoted Reductive Amination of DNA‐Conjugated Amines for DNA‐Encoded Library Synthesis
Authors: Anderson Matthew J. , Carton Thomas P. , Salvini Catherine L. A. , Crawford James J. , Pairaudeau Garry , Waring Michael J. 
Published: January 2024

AbstractDNA‐encoded libraries (DELs) have become a leading technology for hit identification in drug discovery projects as large, diverse libraries can be generated. DELs are commonly synthesised via split‐and‐pool methodology; thus, chemical transformations utilised must be highly efficient, proceeding with high conversions. Reactions performed in DEL synthesis also require a broad substrate scope to produce diverse, drug‐like libraries. Many pharmaceutical compounds incorporate multiple C−N bonds, over a quarter of which are synthesised via reductive aminations. However, few on‐DNA reductive amination procedures have been developed. Herein is reported the application of the micelle‐forming surfactant, TPGS‐750‐M, to the on‐DNA reductive amination of DNA‐conjugated amines, yielding highly efficient conversions with a broad range of aldehydes, including medicinally relevant heterocyclic and aliphatic substrates. The procedure is compatible with DNA amplification and sequencing, demonstrating its applicability to DEL synthesis.
Understanding the Chemical Bond in Semiconductor/MXene Composites: TiO2 Clusters Anchored on the Ti2C MXene Surface
Authors: García‐Romeral Néstor , Keyhanian Masoomeh , Morales‐García Ángel , Viñes Francesc , Illas Francesc 
Published: January 2024

AbstractFirst‐principles calculations on titania clusters (TiO2)n (n=5 and 10) supported on the pristine Ti2C (0001) surface were carried out to understand the properties of semiconductor/MXene composites with implications in (photo)‐catalysis. The reported results reveal a high exothermic interaction accompanied by a substantial charge transfer with a concomitant, notorious, deformation of the titania nanoclusters. The analysis of the density of states analysis of the composite systems evidences a metallic character with titania related states crossing the Fermi level. The picture of the chemical bonds is completed by the analysis of X‐Ray Photoelectron Spectra (XPS) features, evidencing clear shifts of the C(1s) and O(1s) related peaks relative to the isolated systems that have a quite complex origin. This detailed analysis provides insights to experimentalists interested in the design and synthesis of these systems with possible applications in catalysis.
Method of computational design for additive manufacturing of hip endoprosthesis based on basic‐cell concept
Authors: Bolshakov Pavel , Kuchumov Alex G. , Kharin Nikita , Akifyev Kirill , Statsenko Evgeny , Silberschmidt Vadim V. 
Published: January 2024

AbstractEndoprosthetic hip replacement is the conventional way to treat osteoarthritis or a fracture of a dysfunctional joint. Different manufacturing methods are employed to create reliable patient‐specific devices with long‐term performance and biocompatibility. Recently, additive manufacturing has become a promising technique for the fabrication of medical devices, because it allows to produce complex samples with various structures of pores. Moreover, the limitations of traditional fabrication methods can be avoided. It is known that a well‐designed porous structure provides a better proliferation of cells, leading to improved bone remodeling. Additionally, porosity can be used to adjust the mechanical properties of designed structures. This makes the design and choice of the structure's basic cell a crucial task. This study focuses on a novel computational method, based on the basic‐cell concept to design a hip endoprosthesis with an unregularly complex structure. A cube with spheroid pores was utilized as a basic cell, with each cell having its own porosity and mechanical properties. A novelty of the suggested method is in its combination of the topology optimization method and the structural design algorithm. Bending and compression cases were analyzed for a cylinder structure and two hip implants. The ability of basic‐cell geometry to influence the structure's stress–strain state was shown. The relative change in the volume of the original structure and the designed cylinder structure was 6.8%. Computational assessments of a stress–strain state using the proposed method and direct modeling were carried out. The volumes of the two types of implants decreased by 9% and 11%, respectively. The maximum von Mises stress was 600 MPa in the initial design. After the algorithm application, it increased to 630 MPa for the first type of implant, while it is not changing in the second type of implant. At the same time, the load‐bearing capacity of the hip endoprostheses was retained. The internal structure of the optimized implants was significantly different from the traditional designs, but better structural integrity is likely to be achieved with less material. Additionally, this method leads to time reduction both for the initial design and its variations. Moreover, it enables to produce medical implants with specific functional structures with an additive manufacturing method avoiding the constraints of traditional technologies.
A novel approach for constructing privacy‐aware architecture utilizing Shannon's entropy
Authors: Dwivedi Pankaj Prasad , Sharma Dilip Kumar 
Published: January 2024

SummaryThe right to privacy refers to an individual's decision about how personal information can be gathered, utilized, and disseminated. Individual consent and openness are the most important foundations for gaining consumers' confidence, and this pushes businesses to use privacy‐enhancing techniques while developing systems. The purpose of a privacy‐aware design is to safeguard data in such a manner that it does not expand an adversary's current understanding of an individual beyond what would be permitted. When these data pieces are coupled with the plethora of source data accessible outside the system to identify a user, this becomes crucial. Individual privacy is protected by privacy rules all around the globe, but they are often complicated and ambiguous, making their translation into practical and technologically privacy‐friendly structures difficult. The main contribution of this article is that we use Shannon's entropy (SE) to construct an objective measure that may guide our major technical design choices. And for privacy‐aware architecture, simplifying the state‐of‐the‐art security approaches given in the literature.
5‐Aryl Substituted 2‐(2‐Methoxyphenyl)benzoxazoles with Large Stokes Shifts: Synthesis, Crystal Structures and Optical Properties
Authors: López‐Márquez Isaí , López‐Ruiz Heraclio , Merino Gabriel , Vázquez‐García Rosa A. , Corona‐Díaz Alejandro , Pérez‐Estrada Salvador , Rojas‐Lima Susana 
Published: January 2024

Abstract2‐(2‐methoxyphenyl)benzoxazole (MBO) displays similar photophysical properties to 2‐(2‐hydroxyphenyl)benzoxazole (HBO), but it lacks the large Stokes shifts necessary for fluorescence microscopy applications. In this paper, we report the 5‐substitution of MBO with aryl groups to produce 2‐(4‐methoxy‐[1,1’‐biphenyl]‐3‐yl)benzoxazoles (MBBOs) with large Stokes shifts. The synthesis of MBBOs 6–15 was accomplished in moderate to good yields by microwave‐assisted Sonogashira cross couplings. Crystal structures for compounds 6–9 and 15 are provided. MBBOs 6–10, 12, and 14 displayed considerably blue‐shifted absorption maxima and slight bathochromic shifts of their fluorescence maxima relative to the unsubstituted MBO.
Sustainable development during economic uncertainty: What drives large construction firms to perform corporate social responsibility?
Authors: Van Nguyen Minh , Ha Khanh Duy , Phan Chien Thanh 
Published: January 2024

AbstractWhile the world is grappling with economic uncertainty, corporate social responsibility (CSR) has been extensively studied with a focus on favorable economic conditions. This study aims to investigate and prioritize the drivers for CSR in large‐sized construction organizations during economic uncertainty. Based on the literature review and discussions with experienced professionals, 13 critical drivers for CSR were identified and categorized into four clusters. Using the combination of fuzzy Decision Making Trial and Evaluation Laboratory and fuzzy Analytic Network Process (DANP), drivers for CSR performance during economic uncertainty were ranked regarding their interrelationships. Among 13 drivers, the results illustrated that enhancing company reputation was the most critical driver for CSR, followed by long‐term economic benefit, employee commitment and loyalty, and credibility gain. This study expands the current understanding of CSR practices in the construction industry, shedding light on its unique characteristics during economic uncertainty.