bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial activity of human natural killer cells in the absence of accessory cells against extracellularStaphylococcus aureusand hypervirulentPseudomonas aeruginosabacteria
Authors: Guilbaud Audrey , Lottin Baptiste , Cadiou Gwenann , Beauvais Tiffany , Lambot Sylvia , Mouratou Barbara , Labarrière Nathalie , Davodeau François , Pecorari Frédéric 
Published: November 2023

ABSTRACTNatural killer (NK) cells play a crucial role in the innate immune response to bacterial infections, including those due toPseudomonas aeruginosa(P. aeruginosa) andStaphylococcus aureus(S. aureus).In vivo, it has been shown that NK cells are activated by innate accessory cells that detect the presence of bacteria and activate NK cells via a cytokine network.In vitro, several studies have shown that NK cells can also be activated without the help of accessory cells by direct contact with some bacteria species such as extracellularP. aeruginosa. Whether this phenomenon of direct activation is restricted to certain bacterial species, or whether it can be generalized, is still debated, as for example in the case of NK cell activation byS. aureus, which seems to require the intervention of accessory immune cells. Here, we show with co-incubation experiments between NK cells and two bacterial species, that, in the absence of accessory cells, NK cells are able to impede bacterial growth. This has been demonstrated for theP. aeruginosaPA14 strain, which is hypervirulent and known for its deleterious effects on NK cells, as well as for theS. aureusNewman strain. The monitoring of CD107a by flow cytometry suggests that NK cells degranulate after contact withS. aureusbacteria. Our study contributes to the idea that NK cells can be activated in the absence of any accessory cells by various species of bacteria, even an hypervirulent one, and therefore that NKs can directly have an antibacterial effect. This important insight may pave the way for new therapeutic approaches using antibacterial NK-cell engagers.
Host kinase regulation ofPlasmodium vivaxdormant and replicating liver stages
Authors: Glennon Elizabeth KK , Wei Ling , Roobsoong Wanlapa , Primavera Veronica I , Tongogara Tinotenda , Yee Conrad B , Sattabongkot Jetsumon , Kaushansky Alexis 
Published: November 2023

AbstractUpon transmission to the liver,Plasmodium vivaxparasites form replicating schizonts, which continue to initiate blood-stage infection, or dormant hypnozoites that reactivate weeks to months after initial infection.P. vivaxphenotypes in the field vary significantly, including the ratio of schizonts to hypnozoites formed and the frequency and timing of relapse. Evidence suggests that both parasite genetics and environmental factors underly this heterogeneity. We previously demonstrated that data on the effect of a panel of kinase inhibitors with overlapping targets onPlasmodiumliver stage infection, in combination with a computational approach called kinase regression (KiR), can be used to uncover novel host regulators of infection. Here, we applied KiR to evaluate the extent to whichP. vivaxliver-stage parasites are susceptible to changes in host kinase activity. We identified a role for a subset of host kinases in regulating schizont and hypnozoite infection and schizont size and characterized overlap as well as variability in host phosphosignaling dependencies between parasite forms and across multiple patient isolates. Striking, our data point to variability in host dependencies acrossP. vivaxisolates, suggesting one possible origin of the heterogeneity observed acrossP. vivaxin the field.
The LINC complex regulates Achilles tendon elastic modulus, Achilles and tail tendon collagen crimp, and Achilles and tail tendon lateral expansion during early postnatal development
Authors: Pancheri Nicholas M. , Daw Jordan T. , Ditton Destinee , Schiele Nathan R. , Birks Scott , Uzer Gunes , Jones Calvin L. , Penney Brian T. , Theodossiou Sophia K. 
Published: November 2023

AbstractThere is limited understanding of how mechanical signals regulate tendon development. The nucleus has emerged as a major regulator of cellular mechanosensation, via the linker of nucleoskeleton and cytoskeleton (LINC) protein complex. Specific roles of LINC in tenogenesis have not been explored. In this study, we investigate how LINC regulates tendon development by disabling LINC-mediated mechanosensing via dominant negative (dn) expression of the Klarsicht, ANC-1, and Syne Homology (KASH) domain, which is necessary for LINC to function. We hypothesized that LINC regulates mechanotransduction in developing tendon, and that disabling LINC would impact tendon mechanical properties and structure in a mouse model of dnKASH. We used Achilles (AT) and tail (TT) tendons as representative energy-storing and limb-positioning tendons, respectively. Mechanical testing at postnatal day 10 showed that disabling the LINC complex via dnKASH significantly impacted tendon mechanical properties and cross-sectional area, and that effects differed between ATs and TTs. Collagen crimp distance was also impacted in dnKASH tendons, and was significantly decreased in ATs, and increased in TTs. Overall, we show that disruption to the LINC complex specifically impacts tendon mechanics and collagen crimp structure, with unique responses between an energy-storing and limb-positioning tendon. This suggests that nuclear mechanotransduction through LINC plays a role in regulating tendon formation during neonatal development.
Impact of habitual betel quid chewing on cardiovascular risk and outcomes: a systematic review
Authors: Itaki Rodney , Taufa Shalon 
Published: November 2023

AbstractObjectivesHabitual betel quid chewing is a leading cause of oral cancer in Asia-Pacific countries where this practice is prevalent. While health policies have focused on countering betel quid chewing concerning cancer, current policies and health promotion strategies overlook the emerging link to adverse cardiovascular outcomes. This oversight could be due to inadequate studies demonstrating the association between betel quid chewing and cardiovascular risk. To address this gap, we conducted a systematic literature review and narrative synthesis of peer-reviewed published studies showing habitual betel quid use as a cardiovascular risk factor.MethodsWe searched PubMed for studies assessing betel quid chewing and its impact on cardiovascular health. We included primary research on human subjects. Next, we extracted data from eligible studies and stratified by geographical location, study designs and cardiovascular outcomes. Finally, we did a narrative synthesis of the data to identify adverse cardiovascular outcomes associated with chronic betel quid use. We did not do a meta-analysis because of the different study designs, cardiovascular outcomes, and statistical measures.ResultsWe reviewed data from 19 studies that met the inclusion criteria. Habitual betel quid chewing is associated with ischemic heart disease, obstructive coronary artery disease, acute coronary syndrome, and re-hospitalisation following an acute coronary event. Additionally, betel quid use is a risk factor for atrial fibrillation and premature ventricular contractions. Long-term betel quid consumption was associated with elevated risks of all-cause mortality, cancer-related mortality, cardiovascular diseases, and cerebrovascular diseases. Moreover, habitual betel quid users had a higher overall cardiovascular risk. The regular use of betel quid was positively correlated with arterial wall stiffness and was independently associated with heart disease in women. Habitual betel quid use is associated with hypertension.ConclusionsHabitual betel quid chewing is an important cardiovascular risk factor in populations where the practice is prevalent.
Dynamics of property prices and asymmetrical impacts of economic policy uncertainty: new evidence from Indian cities
Authors: Sreenu Nenavath 
Published: November 2023

Purpose
This research study aims to delve into the enduring relationship between housing property prices and economic policy uncertainty across eight major Indian cities.

Design/methodology/approach
Using the panel non-linear autoregressive distributed lag model, this study meticulously investigates the asymmetric impact of economic policy uncertainty on apartment and house (unit) prices in India during the period from 2000 to 2022.

Findings
The findings of this study indicate that economic policy uncertainty exerts a negative influence on property prices, but noteworthy asymmetry is observed, with positive changes in effect having a more pronounced impact than negative changes. This asymmetrical effect is particularly prominent in the case of unit prices.

Originality/value
This research reveals that long-run price trends are also influenced by factors such as interest rates, building costs and housing loans. Through a comprehensive analysis of these factors and their interplay with property prices, this research paper contributes valuable insights to the understanding of the real estate market dynamics in Indian cities.
Contouring of the regulatory governance framework in emerging economies: a novel multidimensional approach
Authors: Mishra Brajesh , Kumar Avanish 
Published: November 2023

PurposeGlobally, the governance has shifted from positivist to the regulatory-centric approach, necessitating accurate contouring of regulatory governance framework. The study proposes a novel approach to unravel the regulatory governance framework in the context of the Indian electronics industry – extendable to other sectors in India and other emerging economies.Design/methodology/approachThe research objective has been operationalized through document analysis and thematic analysis of semi-structured interview transcripts in three steps: (1) arrive at parameters of the regulatory governance framework, (2) identify instruments against each parameter and (3) characterize parameters in terms of dominant instruments and their underlying modalities. The authors have adopted a set of 6 Cs modalities (control, communications, competition, consensus, code and collaboration) and regulatory space theory to analyze existing modalities mix in the dominant instruments.FindingsIn summary, the study has (1) identified eight macro and twenty micro regulatory governance parameters, (2) mapped regulatory governance parameters with instruments and institutions (3) revealed the top two dominant modalities for each regulatory governance parameter.Practical implicationsThe existing modality characteristics of regulatory governance parameters can be used by manufacturers, investors and other stakeholders to make a realistic assessment of regulatory governance and reduce regulatory risk and regulatory burden.Originality/valueThe multidimensional use of parameters, instruments and modalities broadens the understanding of the existing regulatory governance framework and may assist the regulators in optimizing it to meet market requirements.
Mercaptobenzothiazole functionalized ionic liquids as additive in lithium complex grease: rheological and tribological performances
Authors: Yang Huimin , Ye Chunlin , Li Yi , Zhang Songwei 
Published: November 2023

Purpose
This study aims to probe the applicability of 2-mercaptobenzothiazole (MBT) functionalized ionic liquids (ILs) as additives in lithium complex grease (LCG) by researching the corrosion inhibiting, rheological and tribological performances.

Design/methodology/approach
Electrochemical tests such as electrochemical impedance spectroscopy and potentiodynamic polarization curves were used on Gamry electrochemical workstation to research the corrosion inhibition properties of ILs in 1.0 M HCl corrosive solution. The rheological properties of different grease samples were tested on a rheometer. The tribological properties were investigated on SRV-V oscillating reciprocating friction and wear tester. Scanning electron microscope, X-ray spectrometer and X-ray photoelectron spectrometer were used to characterize the lubricating mechanism.

Findings
The 2-MBT functionalized ILs have excellent corrosion inhibition properties. When used as additives in LCG, they both exhibited enhancing effects on thermostability, colloid stability and structural recoverability, and furthermore, outstanding friction-reducing and antiwear properties were also obtained. Surface analysis indicated that the superior lubricating performances of 2-MBT functionalized ILs were mainly ascribed to the formation of tribochemical products on wear tracks, including organic compounds with C–O bond, Fe2O3 and FeS2.

Originality/value
The 2-MBT-based ILs synthesized in this study were multifunctional additives with excellent corrosion inhibiting and tribological properties, which would have a very broad application prospect in lubricating grease industry.
Behavioral biases and the rational decision-making process of financial professionals: significant factors that determine the future of the financial market
Authors: Khare Tanu , Kapoor Sujata 
Published: November 2023

PurposeThis paper describes how financial professionals' behavioral biases influence their financial forecast and decision-making process. Most of the earlier studies are focused on well-developed financial markets, and little is researched about financial professionals, such as institutional investors, portfolio managers, investment advisors, financial analysts, etc., in emerging markets.Design/methodology/approachAn expert-validated questionnaire measure four prominent behavioral biases and Indian financial professionals' rational decision-making process. The final sample consists of 274 valid responses using the purposive sampling technique. IBM SPSS and AMOS structural equation modeling (SEM) software are used to build measurement and structural models, multivariate analysis including regression, factor analysis, etc.FindingsThe results provide empirical insights into the relationship between behavioral biases and the decision-making process. The results suggest that the structural path model closely fits the sample data. The presence of behavioral biases indicates that financial professionals' forecasting and decision-making is not always rational but bounded rational or irrational due to these factors. Furthermore, these biases (except overconfidence bias) have a markedly significant and positive relationship with irrational decision-making.Research limitations/implicationsIt is critical to eradicate these psychological errors, but awareness and attentiveness toward behavioral biases may help financial professionals to make informed decisions. Investors can improve their portfolio decisions and investments by recognizing their judgment errors and focusing on specific investment strategies to mitigate the impact of these biases. It is necessary to incorporate behavioral insights while developing training techniques for financial professionals. Rules of thumb, visual tools, financial coaching and implementing social-cultural elements in training programs enable financial professionals to develop simple, engaging, appealing and customized approaches for their clients.Originality/valueThis novel study is the first of this kind of research that examines the relationship between financial professionals' behavioral biases and rational decision-making process. This study significantly and remarkably provides insights into irrationality in financial professionals' decision-making.
Greening the bottom line: a new scale to discern consumer perceptions of a firm’s green orientation
Authors: Ramirez Edward , Moreno Gabriel , Hadjimarcou John 
Published: November 2023

Purpose
The purpose of this paper is to introduce a new scale designed to assess a firm's green orientation from the consumer's perspective. Its effects are tested on a managerially relevant outcome variable and an objectively measured product-performance indicator.

Design/methodology/approach
Four studies based on various data sources identify and operationalize a green-oriented firm. Leveraging signaling theory, a model tests the orientation’s impact on two outcome variables, behavioral intentions and revenue, demonstrating its relevance to both scholars and practitioners.

Findings
Previous research has explored consumers’ reactions to green products, announcements and initiatives in a piecemeal fashion. This study suggests that firms are perceived as green-oriented when they operate in an environmentally friendly manner, develop green products and publicize these accomplishments. Consequently, consumers’ identification of a firm as green-oriented affected their behavioral intentions, which positively influenced firms’ revenues.

Research limitations/implications
Green-oriented firms must incorporate environmental standards into production efforts and confidently trumpet such behaviors if they wish to profit from consumer perceptions.

Practical implications
To accrue positive behavioral intentions from consumers and to increase the firm’s revenues, marketers should invest in developing green-oriented products, operating in an environmentally friendly manner and publicizing these efforts. Understanding consumer perceptions is critical, as they are a leading indicator of firm performance.

Originality/value
This novel operationalization of a green orientation captures consumers’ perceptions, demonstrating that firms can significantly benefit from this consumer-aligned strategy.
GPT revolution and digital entrepreneurial intentions
Authors: Abaddi Samer 
Published: November 2023

Purpose
Generative pretrained transformers (GPTs), soaring to one million users at lightning speed, outpaced social media giants (15 times faster) (Buchholz, 2023). Despite this, scant research explored GPT’s impact on the digital entrepreneurial intentions (EIs) of students and tech-savvy generations. This study aims to pioneer a fusion of the technology acceptance model (TAM) and the theory of planned behavior (TPB), bridging the gap in research.

Design/methodology/approach
In this bold quantitative quest, business administration students became fearless participants, engaging in a survey of profound significance. Guided by the mighty powers of G*Power and Stata’s structural equation modeling builder, the intricate relationships within a robust sample of (n = 400) were unraveled.

Findings
The mediating power of GPT usefulness and GPT ease of use part of the TAM emerges, paving the way for a future brimming with digital entrepreneurship (DE) boundless possibilities. Predictably, the study found that TPB constructs also affect the EI of students.

Originality/value
This groundbreaking study brings together the powerful combination of TAM and TPB, while pioneering the exploration of GPT models’ mediating role. Its findings offer invaluable contributions to the field of DE and policymakers.
Fast-food consumption and individual time preferences in Russia: evidence for the social policy
Authors: Kossova Tatiana , Sheluntcova Maria 
Published: November 2023

PurposeThis article aims to investigate the role of socioeconomic factors and individual time preferences in the demand for fast-food in Russia. An individual discount rate shows the ability of a person to postpone utility from consumption to future periods.Design/methodology/approachAn individual discount rate is measured through a hypothetical money experiment. The database is the special survey of the Levada analytical center conducted in 2017. Multivariate probit model enables the authors to consider the possible endogeneity of individual discount rate and reveal the relationship between socioeconomic factors and frequent fast-food consumption.FindingsResults show that a higher individual discount rate is related to frequent consumption of fast-food. At the same time, there are factors that provoke both a higher individual discount rate and the refusal of frequent consumption of fast-food. Findings advise the prioritization of measures highlighting the short-term benefits of healthy eating and the short-term costs of avoiding it.Originality/valueTo the authors' knowledge, this article is the first one which presents comprehensive investigation of microeconomic factors of fast-food consumption in Russia including individual time preferences of consumers.
How does your cultural intelligence contribute to your adjustment? Unveiling the link between cultural intelligence and cross-cultural adjustment using meta-analysis
Authors: Tripathi Chhaya Mani , Kaurav Rahul Pratap Singh , Singh Tripti 
Published: November 2023

PurposeThe purpose of this study is to examine the relationship between cultural intelligence (CQ) and cross-cultural adjustment (CCA) using meta-analytic methods. The paper serves a dual purpose as it critically examines the CQ-CCA literature and provides summary effects using meta-analysis to determine how CQ and its facets affect CCA and its three dimensions.Design/methodology/approachA meta-analysis of 77 studies involving 18,399 participants was conducted to obtain the summary effects. The studies reporting the relationship of CQ and/or its facets with CCA or any of its dimensions were included in the analysis.FindingsResults revealed that CQ (overall) and all individual CQs were positively and significantly related to CCA and its three subdimensions. Although CQ (overall) had a strong effect on CCA and moderate to strong effects on all the subdimensions of CCA, the strongest effect size was measured for the relationship of motivational CQ with CCA. Not only this, when individual CQs' relationships were assessed with the individual adjustment dimensions, the motivational aspect of CQ happened to be the most influencing factor, having a close to strong effect on interaction adjustment.Research limitations/implicationsSince the study combines the results from numerous empirical research conducted over time, it avoids the limitations that an individual study has, which is carried out at a single point in time and on a limited sample.Originality/valueThis study adds to the academic research by critically reviewing the CQ-CCA literature. It also works as a guiding map for future research in the area. The study highlights the summary effects for each association between CQ and CCA and their dimensions, elucidating the mixed findings reported in previous research.