bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Impella Device Support and Elevated Rates of Gout Flares: A Retrospective Analysis
Authors: Sinclair Jorge , Isha Shahin , Olivero Lorenzo , Raavi Lekhya , Narra Sai Abhishek , Paghdar Smit , Jonna Sadhana , Satashia Parthkumar , Hannon Rachel , Blasavage Jessica , White Layton , Olanipekun Titilope , Bansal Pankaj , Kiley Sean , Leoni Juan Carlos , Nativí Jose N. , Lyle Melissa , Thomas Mathew , Sareyyupoglu Basar , Pham Si , Smith Michael , Franco Pablo Moreno , Patel Parag , Sanghavi Devang 
Published: November 2023

Abstract
Background
Impella is an advanced ventricular assist device frequently used as a bridge to heart transplantation. The association of Impella with increased rates of gout flares has not been studied. Our primary aim is to determine the rates of gout flares in patients on Impella support.
Methodology
A retrospective study was conducted between January 2017 and September 2022 involving all patients who underwent heart transplantation. The cohort was divided into groups based on Impella support for statistical analysis. In patients receiving Impella support, outcome measures were compared based on the development of gout flares.
Results
213 patients were analyzed, with 19.71% supported by Impella. Impella and non-Impella groups had similar age, race, and BMI, but more males were in the Impella group. Gout and chronic kidney disease were more prevalent in Impella-supported patients, while coronary artery disease was less common. The incidence of gout flare was significantly higher in Impella patients (31% vs. 5.3%). The Impella group had an adjusted odds ratio for in-hospital gout flare of 8.069 (95% CI = 2.13–35.08, P = 0.003). Impella-supported patients with gout flares had longer intensive care unit and hospital stays but no difference in mortality or other outcomes.
Conclusion
Our study is the first to identify the potential association between Impella support and increased rates of gout flares in hospitalized patients. Future studies are required to confirm this association and further elucidate the biological pathways. It is imperative to consider introducing appropriate measures to prevent and promptly manage gout flares in Impella-supported patients.
The sex ratio after IVF long-time vs. short-time insemination and ICSI vs. Re-ICSI fertilization
Authors: Jiang Yan , Geng Cai-Ping , Wang Xiao-dan , Pan Shu-hong , Wu Xiao-hua 
Published: November 2023

Abstract

Context: The live birth sex ratio in IVF/ICSI babies was influenced by the use of ICSI, or blastocyst transfer.
Aims: To investigate the live birth sex ratio after IVF long-time vs. short-time insemination and ICSI vs. Re-ICSI fertilization.
Methods: We conducted a retrospective cohort study including patients undergoing IVF or ICSI with autologous oocytes from 2012.1 to 2023.8. A total of 5565 babies were born from 4393 women. The secondary sex ratio (SSR) was analyzed between IVF long-time vs. short-time insemination and ICSI vs. Re-ICSI fertilization.
Key Results: The SSR of IVF/ICSI babies in our center 52.69% (2932/5565). And comparing to long-time IVF, short-time insemination decrease the percentage of male babies in singleton in fresh ET and D6 blastocyst in FET. Comparing to ICSI, Re-ICSI decrease the percentage of male babies in D5 blastocyst ET.
Conclusions: SSR was associated with long-time vs. short-time IVF and ICSI vs. Re-ICSI fertilization methods.
Angiotensin II receptor blockers reduce the need to perform a prostate biopsy
Authors: Uemura Hiroji , Kawahara Takashi , Itoh Yusuke , Kobayashi Kazuki , Takizawa Akitoshi , Ohta Jun-ichi , Udagawa Kouichi , Maeda-Minami Ayako , Mano Yasunari , Mutoh Michihiro , Matsuyama Yutaka , Ishikawa Hideki 
Published: November 2023

Abstract
BACKGROUND
The prevalence of prostate cancer (PCA) in elderly men increases with age. Various studies have reported the impact of antihypertensive drug exposure on PCA patients. We focused on the use of angiotensin II receptor blockers (ARBs) in men undergoing a prostate biopsy using real clinical practice and large medical information data.
Methods
The JMDC Claims database (MC) [name JMDC data as MC] was used, which contains information on Japanese employment-based health insurance programs. We selected patients with a suspected PCA diagnosis in 2016 and examined them by age in the non-antihypertensive, non-ARB, and ARB groups. As practice data, we investigated 858 patients with suspected PCA who underwent a prostate biopsy (PB) [name prostate biopsy data as PB] in 2016 at 7 affiliated hospitals for urological sites. The number of biopsies by age was compared between the ARB, non-ARB, and non-antihypertensive groups.
Results
According to the JMDC data, the percentage of individuals using antihypertensive medications was 47.4% in the non-ARB (MC) group and 31.2% in the ARB (MC) group. In both groups, the proportion tended to increase with age. Based on data from the seven affiliated hospitals, the number of individuals receiving biopsies increased with age in both the non-ARB (PB) and ARB (PB) groups. The overall rates were 45.7% in the PB (PB) group and 24.4% in the PB (PB) group. The biopsy recipient risk ratio was 0.78 (0.69–0.88) in the ARB (PB) group. The ARB (PB) group had significantly lower rates of prostate biopsies than the non-ARB (PB) group. The cancer positivity rates in the non-ARB (PB) group and PB groups (PB) were 53.8% and 53.6%, respectively.
ConclusionS
Although the cancer-positive rates did not differ markedly between the non-ARB (PB) and ARB (PB) groups, we confirmed that ARB reduced the likelihood of a biopsy requirement compared to non-ARB.
3D Imaging as a Method of Measuring Serotiny
Authors: Mantgem Carolyn van 
Published: November 2023

Abstract

Background: Serotiny refers to delayed seed dissemination within plants. Serotiny, or pyriscence, plays an important role in species’ reaction to fire thus accurately understanding the variation of adaptations falling under the umbrella term of serotiny is crucial to predicting the ecosystems reaction to changing fire regimes. Due to the irregular shape of cones, surface area measurement is problematic. Past studies have relied on visual estimation to determine the openness of cones or to identify when cones become open. Subjective assessments of cone opening potentially could be subject to measurement errors. In this study I demonstrate the effectiveness of 3D modeling using a readily available phone camera to quantify differences in surface area of cones before and after heating treatments. I demonstrate this method by comparing two serotinous conifer species, Monterey cypress (Hesperocyparis macrocarpa) and Bishop pine (Pinus muricata).
Results: Bishop pine had an average surface area increase of 175.7% while Monterey cypress had an average surface area increase of 43.5%. Paired t-tests showed that surface area significantly increased following heating for both species.
Conclusions: Bishop pine showed a much greater surface area change relative to Monterey cypress. 3D imaging with Polycam proved to be a successful method of quantifying cone opening, creating a mesh that could be measured with Blender. Using a readily available phone camera, one can create an accurate 3D model to measure changes in surface area of cones before and after fire. Further experimentation using this method could include comparisons between serotinous species, facultative serotinous species, as well as non-serotinous species. Simple methods for quantifying serotiny, such as demonstrated here, allows for improved understanding and predictions of how species respond to fire and other environmental triggers. This method of quantifying the reactiveness of species’ cone opening to heat requires further investigation but holds promise in further defining the role in which fire plays in seed dispersal due to cone opening.
Research on Design and Cutting Performance of Revolving Lemniscate Milling Cutter
Authors: Fan Mengchao , Bi Chunxu , Liu Xianli , Ding Mingna , Song Huixu 
Published: November 2023

Abstract
An increasing number of cutting tools with different geometric shapes are needed owing to the increasing complexity of the workpiece surfaces in aerospace and automotive molding. A new kind of milling cutter is designed, which is named as revolving lemniscate milling cutter(RLMC for short). The parametric mathematical models of RLMC are proposed. Mathematical models of cutting edge curves are proposed to provide the theoretical basis for RLMC precision manufacturing. Equivalent helix angle, curvature radius of tool rotation surface, effective cutting linear velocity and scallop height are studied. Corresponding numerical simulation results are also provided as graphical representations. Three RLMC with different tool parameters are manufactured and contrast experiments are conducted to prove that using RLMC in end milling can achieve better machining quality. The parametric design and application research provides a new method and theoretical basis for other new types of milling cutters.
Screening and identification of key biomarkers in osteoarthritis: evidence from experiment and bioinformatics analysis
Authors: Zhang Dejian , yin haoran , qiao haoran , Luo Shengfei , Zhao Lixi , min hongwei 
Published: November 2023

Abstract

Objective we screened and identified key genes and pathways related to the synovial inflammatory response in KOA to better study the molecular mechanism of action.Methods Two main datasets from a professional comprehensive gene expression database were downloaded; namely, GSE55235 and GSE55457. GEO2R is a tool for analysis of differentially-expressed genes (DEGs) based on the Gene Expression Omnibus (GEO) database, and we used this to identify DEGs, then performed RNAseq from samples of KOA and normal synovium (Experimental Group, EG). Based on these three datasets, a total of 49 DEGs were identified, consisting of 36 downregulated genes and 13 upregulated genes. GO enrichment analysis and KEGG enrichment analysis of data were performed with the help of Webgestalt and metascape. Cytoscape software was used to import the PPI network, and then the first five percent of genes were tagged as Hub genes.Results Three hub genes–FOSL2, NR4A1, and ATF3–were identified and may be involved in the pathogenesis of KOA.Conclusions This study analyzed DEGs and hub genes in inflamed KOA synovium, which may help us understand the pathogenesis of KOA and provide candidate targets for diagnosis and treatment of OA.
Protocol for A systematic review and meta-regression On Effectiveness of Problem-solving therapy for management of Geriatric Depression
Authors: Antony Annu , Rajan Varsha , Kumbha Gopi , Parida Swayam Pragyan , Behra Priyamadaba , Padhi Susanta K 
Published: November 2023

Abstract
Introduction
The fast-ageing world, with the increasing prevalence of Mental health disorders, requires strengthening primary health care equipped with innovative interventions. Problem solving therapy is cognitive behavioural therapy which can be administered in primary health care effectively by a trained primary health care professional without increasing mean consultation time. Thus, a comprehensive update on the literature focusing on various settings and types of healthcare professionals administering problem-solving therapy for geriatric depression will enhance the knowledge about a possible intervention for geriatric depression at resource-limited settings.
Methodology
This protocol follows Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic search was done in four electronic databases MEDLINE (via PubMed), Web of Science, Cochrane Library, and CINAHL. We will also search for grey literatures and missed out literatures in trial registers, cross references, LILACS, Open Grey, dissertations/thesis and reports. We will include randomised controlled trials, in which any problem solving intervention is compared with usual care or alternative treatment and reports depression as an outcome. Both title and abstract screening and full-text screening will be done by two reviewers. The Cochrane Collaboration revised tool of Risk of Bias will be applied to perform risk of bias assessment. The data will be extracted using a pilot tested extraction form. We will categorise the results separately for every setting. If a group of sufficiently comparable studies will be identified, we will perform a meta-analysis applying random effects model. We will investigate heterogeneity using a combination of visual inspection of the forest plot along with consideration of the χ2 test and the I2 statistic results. A meta-regression will be done to assess the heterogenicity due to different variables.
Ethics and Patient Participation
As this is a protocol for a systematic review and no participant recruitment will take place, no human participant will be involved in study design, data collection or outcome measure. The results of the review will be disseminated in an open-access journal to ensure access to all.
Effect on Tall Building at Distinct Wind Angle
Authors: Sharma Niraj , Roy Amrit Kumar 
Published: November 2023

Abstract
The aim or objective of the project is to determine interference among two adjacent tall buildings. Computational fluid dynamics was used after modelling the structures in stiff full-scale forms. Using the interference effects from another square plan tall buildings of the same height at 0° WIA, ANSYS CFX analyses pressure variations on sidewalls of a square plan tall building. It can be said that these buildings are closely located – from 0.4h to h, h being a height of a building. Using the square plan shaped building in its isolated condition as a point of comparison, the analysis also compares it to square shape buildings located in other places. Comparisons are illustrated using the interference factors (IF) and IF contours. At times there is recorded a deviant pressure distribution. Apart from that, it is noticed that the interfering buildings have a shielding and channelling influence over the square plan formed building. When there is interference on square plan-shaped building faces, the pressure distribution becomes unpredictable. We get the Cp for each face of the square plan-shaped building in each interfering situation by simply multiplying IF and Cp separately with the integral factor of two situations in an isolated case.
Defining Applicability Domain in Biodegradation Pathway Prediction
Authors: Dost Katharina , Tam Jason Y C , Lorsbach Tim , Schmidt Sebastian , Wicker Jörg 
Published: November 2023

Abstract
When developing a new chemical, investigating its long-term influences on the environment is crucial to prevent harm. Unfortunately, these experiments are time-consuming. In silico methods can learn from already obtained data to predict biotransformation pathways, and thereby help focus all development efforts on only the most promising chemicals. As all data-based models, these predictors will output pathway predictions for all input compounds in a suitable format, however, these predictions will be faulty unless the model has seen similar compounds during the training process.
A common approach to prevent this for other types of models is to define an Applicability Domain for the model that makes predictions only for in-domain compounds and rejects out-of-domain ones. Nonetheless, although exploration of the compound space is particularly interesting in the development of new chemicals, no applicability Domain method has been tailored to the specific data structure of pathway predictions yet.
In this paper, we are the first to define Applicability Domain specialized in biodegradation pathway prediction. Assessing a model’s reliability from different angles, we suggest a three-stage approach that checks for applicability, reliability, and decidability of the model for a queried compound and only allows it to output a prediction if all three stages are passed. Experiments confirm that our proposed technique reliably rejects unsuitable compounds and therefore improves the safety of the biotransformation pathway predictor.
A Satellite Network Service Function Chain Orchestration Method Based on Node Stability
Authors: Hu Hefei , Qi Panjie , Wu You , Zhang Ziyi 
Published: November 2023

Abstract
Satellite networks are on the brink of becoming pivotal components in future communication systems, thanks to their extensive coverage and multicast capabilities, especially in the context of the emergence of Software-Defined Networking (SDN) and Software-Defined Satellite Networks (SDSN), which enable the provisioning of services within orbit. However, the changes in satellite network topology inevitably result in a degradation of service quality and significantly improve the expenditure for ensuring the quality of service for users. It’s noteworthy that existing research predominantly focuses on deploying service function chains(SFCs) within satellite networks, with relatively less attention devoted to the intricate challenges associated with SFC readjustments caused by the movements of satellites. To address this pressing issue, we introduce the innovative definition of ”satellite node stability.” This definition effectively utilizes information on the adjacent time-slice network topology to evaluate the importance of nodes within the SFC orchestration process in satellite networks. Furthermore, we propose a methodology for assessing the quality of SFC orchestration schemes within satellite networks. Building upon this approach, we present a tailored SFC orchestration method designed to suit the unique characteristics of satellite networks. Simulation results indicate that this approach can enhance the overall revenue for service providers by approximately 9% without compromising the service deployment success rate. Even more noteworthy is its ability to reduce the total expenditure on service function chain readjustments resulting from satellite movements by around 20%.
Correction of over-dosed insulin in a type-2- diabetic led to a better control of glycemia and arterial hypertension: a case report
Authors: Abobarin-Adeagbo Abimbola , Kraya Torsten , Girndt Matthias , Pliquett Rainer Ullrich 
Published: November 2023

Abstract
Background:An association between hypoglycemia and arterial hypertension has been proposed. Here, for the first time, we report a case of a chronically over-dosed insulin therapy with uncontrolled hypertension, which improved after insulin-dose reduction.Case Presentation: A 73-year-old, male type-2 diabetic of Caucasian ethnicity was hospitalized for uncontrolled arterial hypertension and weakness. Prior to hospitalization, a fixed-dose insulin therapy (160 units per day) and antihypertensive medication with urapidile, valsartan and bisoprolol were prescribed. Hemoglobin A1c was 11.2%, symptomatic hypoglycemic episodes were not reported. During hospitalization, metformin, empagliflozin, and dulaglutide (1.5 mg per week) were added to insulin. Conventional insulin therapy was switched to an intensified insulin therapy with a cumulative daily dose of 46 units. 22 months after discharge, the medical therapy consisted of metformin, liraglutide, and insulin glargine (26 units per day), antihypertensive medication was reduced to bisoprolol and valsartan. Blood pressure was well controlled, hemoglobin A1c was 6.6%. As a likely explanation, undocumented, asymptomatic hypoglycemic events with a post-hypoglycemic hormonal stimulation were the cause for the poor glycemic and blood-pressure control. A step-wise reduction of insulin translated into a better glycemic and blood-pressure control.Conclusions: Undocumented, asymptomatic hypoglycemic events and post-hypoglycemic hormonal stimulation were the likely cause for the poor glycemic and blood-pressure control prior to index hospitalization. A step-wise reduction of insulin concurrently translated into a better glycemic and blood-pressure control.
Pembuatan Antarmuka Website Desa Jambuwuluk Menggunakan Metode User Centered Design
Authors: Sambo Denis Irwanto , Nugraha Kristian Adi , Delima Rosa 
Published: November 2023

The information technology used in Jambuluwuk Village Office consists of computer devices that utilize a system provided by the village government to assist in the administrative services of Jambuluwuk Village. This system can be accessed easily by the community and village staff anytime and anywhere through the village's website at https://jambuluwuk.online/, using an internet connection. Despite the positive aspects of the website, there are some issues identified on the Jambuluwuk Village website. One of the problems is the inconsistent display in one of the menus, namely the Village Government menu, which discusses the organizational structure of the village administration. The organizational structure is important information for the residents, particularly the Jambuluwuk Village staff. Currently, the Village Government menu only displays the names of the village staff without utilizing charts or structures. This makes it difficult for the village staff to understand the organizational structure as there is no information explaining the hierarchy or levels of each division in Jambuluwuk Village.
During the design and implementation of the Jambuluwuk Village website, the researcher utilized the User-Centered Design (UCD) method. This was done because the researcher focused on user requirements, and the method was optimized to fulfill the needs and desires of end users. Subsequently, the researcher conducted testing using the System Usability Scale (SUS) method.
The website of Jambuluwuk Village has two actors: the admin and the users (village residents). The website is built using PHP, the Laravel framework, XAMPP, and the MySQL database.
Comparative evaluation of daily streamflow prediction by ANN and SWAT models in two karst watersheds in central south Texas
Authors: Mei Xiaohan , Smith Patricia K. , Li Jing 
Published: November 2023

Abstract

This work compares the accuracy of streamflow estimated by a data-driven artificial neural network (ANN) and the physically based soil and water assessment tool (SWAT). The models were applied in two small watersheds, one highly urbanized and the other primarily covered with evergreen forest and shrubs, in the San Antonio region of central south Texas, where karst geologic features are prevalent. Both models predicted daily streamflow in the urbanized watershed very well, with the ANN and SWAT having the Nash–Sutcliffe coefficient of efficiency (NSE) values of 0.76 and 0.72 in the validation period, respectively. However, both models predicted streamflow poorly in the nonurban watershed. The NSE values of the ANNs significantly improved when a time series autoregressive model structure using historical streamflow data was implemented in the nonurban watershed. The SWAT model only achieved trivial performance improvement after using the SWAT-CUP SUFI-2 calibration procedure. This result suggests that an ANN model may be more suitable for short-term streamflow forecasting in watersheds heavily affected by karst features where the complex processes of rapid groundwater recharge and discharge strongly influence surface water flow.