bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thyroid metastasis from renal cell carcinoma presenting as a solid mass with rapid enlargement
Authors: Chiardi Isabella , Gaffuri Priska , Leoncini Andrea , Trimboli Pierpaolo 
Published: January 2024

Summary
Thyroid metastases from nonthyroidal malignancies (NTMs) represent a diagnostic challenge, often displaying heterogeneous clinical manifestations. These metastases are rare but significant, accounting for approximately 2% of thyroid malignancies. Distinguishing them from primary thyroid malignancies is challenging due to the lack of specific ultrasound features, and the ultrasound-based risk stratification systems offer limited utility in such cases. Fine needle aspiration cytology is crucial for definitive diagnosis, yet it may not always provide accurate results. In this case report, we describe a unique instance of thyroid metastases originating from renal cell carcinoma, emphasizing the complexities in diagnosis and the importance of considering oncological conditions when assessing thyroid masses. Awareness of thyroid metastasis from NTMs, particularly in cases of diffuse thyroid hypoechogenicity and hypothyroidism, is essential for clinicians in their diagnostic approach.

Learning points

Thyroid metastases from nonthyroidal malignancies are diagnostic challenges due to their heterogeneous clinical presentations, often mimicking primary thyroid malignancies.

Thyroid metastases from nonthyroidal malignancies are relatively rare, but they still account for approximately 2% of thyroid malignancies.

It is fundamental to consider oncological conditions when assessing thyroid masses, especially in cases of diffuse thyroid hypoechogenicity, hypothyroidism, and history of other tumors.

Thyroid presentation is quite similar to that of autoimmune hypothyroidism, endocrinologists must be aware of the possibility of thyroid hypofunction due to the massive invasion of the parenchyma.
Coding Examples: Neonatal Critical Care and Intensive Care Services
Authors:   American Academy of Pediatrics
Published: January 2024

The examples in this article promote understanding of the Current Procedural Terminology (CPT®) reporting guidelines for intensive and critical services provided to neonates and infants. Examples of code selection include the following:
Delivery room care and initial intensive or critical care Initial and subsequent days of care Critical care and transfer of care Concurrent critical care services
Characteristics of marine strain Streptomyces sp. with antimicrobial and cytotoxic activity
Authors: Ivanytsia V. O. , Shtenikov М. D. , Strashnova I. V. , Korotaіeva N. V. , Tytarenko N. V. , Gudzenko T. V. , Vasylieva N. Y. , Gorshkova O. G. , G. V. Lisіutin  , Potapenko K. S. , Andriushchenko O. V. , Chaban M. M. 
Published: January 2024

The Black Sea is a unique water basin consisting of a thin superficial oxygenic layer with moderate salinity, and a deep anoxic water mass. The microbiota of the Black Sea remains relatively understudied, which makes it interesting first of all from the most practical point of view of the search for producers of new biologically active compounds. A strain of actinobacteria Streptomyces sp. ONU 561 was isolated from the surface of mussel shells collected in the coastal zone of Odesa. It demonstrated a wide range of antagonistic activity, inhibiting the growth of a set of opportunistic pathogens, including representatives of Staphylococcus aureus, Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae. In addition, bacteria of this strain were able to inhibit the growth of all tested strains of mycelial fungi, including representatives of Aspergillus niger, A. flavus and Fusarium oxysporum species, and Candida albicans yeast. A significant cytotoxic effect was revealed in the cell cultures of human malignant cells – human rhabdomyosarcoma (RD) and human laryngeal adenocarcinoma (Hep-2). Analysis of the exometabolome of the strain did not explain these effects.The strain was comprehensively characterized, including physiological, biochemical, and morphological traits. The complete genome of the strain was sequenced using Illumina HiSeq 4000 (2x150) and ONT and annotated using NCBI PGAP. Its genome has a size of 8 359 197 bp. GC content – 71.59%. Using antiSMASH 7.0, 35 biosynthetic clusters were revealed. The indices of digital DNA-DNA hybridization and orthoANI for all of the type strains with Streptomyces sp. ONU 561 are much lower than threshold values for the species separation. The obtained results, including a comparative analysis of the genome, indicate the possible affiliation of the strain Streptomyces sp. ONU 561 to a new species and the potential ability of these actinobacteria to synthesize previously unknown antibiotic compounds.
Dynamic Location Model of Intermediate nodes within safety zones in focused logistics context
Authors: Kalenatic Dusko , López Bello Cesar Amílcar , González Leonardo José , Rueda Velasco Feizar Javier 
Published: January 2024

This paper presents a mixed integer programming model for multiple logistics node location in order to support decision making processes as a function of combat units movement. The model let us to obtain a dynamic configuration for a supply network in operational logistics. With this purpose focused logistics concepts are employed as a last tendency for sustaining military operations. The model offers the possibility of use safety zones modeled as a spatial constrains which pretend to give warranties about survivability, operability, supplies continuity and flexibility in a hostile environment.
Red derivacional de la palabra godín en el español de México
Authors: Zacarías Ponce de León Ramón 
Published: January 2024

En esta investigación analizaremos el origen de la palabra godín, su estructura morfológica, su ampliación semántica y la red derivacional a la que ha dado lugar. Esta palabra se utiliza para referirse a un tipo de trabajador que se conoce también como burócrata. Son oficinistas que acuden en horario fijo a su lugar de trabajo; suelen llevar comida de casa y establecen camaradería con sus colegas de escritorio. Lo interesante de esta palabra es que ha dado origen a otras palabras derivadas que extienden el concepto y crean una red derivacional neológica. Entre las palabras que podemos mencionar se encuentran: godinato, godinazo, godinear, godinesco, godinista, entre otras. Una red derivacional permite extender un concepto, digamos nominal, para crear verbos, adjetivos y adverbios con rasgos semánticos semejantes pero distinto comportamiento gramatical. Asimismo, estos conceptos nuevos pueden crear a su vez nuevas palabras en un segundo orden de derivación: por ejemplo, el sustantivo godín da lugar al verbo godinear, en un primer orden; a su vez, godinear se puede derivar, en un segundo orden de derivación en un nuevo sustantivo, godineo. En esta contribución demostraremos que esta nueva red derivacional es similar a otras que conforman palabras establecidas (Díaz-Negrillo, 2021), lo cual nos deja entrever que el entramado léxico está organizado de forma lógica y cíclica. Esto nos permite afirmar que el camino que sigue un concepto nuevo en su desarrollo léxico puede ser pronosticado hasta cierto punto.
Monoclonal immunoglobulin as a prognostic factor for the severity of bone damage in paraproteinemic hemoblastoses and Waldenström’s macroglobulinemia
Authors: Pisarevskaya O. N. , Alekseev S. A. , Rukavitsyn O. A. 
Published: January 2024

Aim. Identify risk factors for the development of osteodestructive syndrome. To determine the relationship between the types of secreted monoclonal immunoglobulin (paraprotein) and the severity of osteodestructive syndrome in patients with paraproteinemic hemoblastoses (PH) and Waldenström’s macroglobulinemia (WM).Materials and methods. A retrospective analysis of data from 116 patients with PH and WM was performed. 104 patients (89.6 %) were diagnosed with multiple myeloma. Less commonly observed were WM (in 8 patients – 6.9 %), plasma cell leukemia (in 2 patients – 1.8 %), solitary plasmacytoma and monoclonal gammopathy of unknown significance were diagnosed in one case (0.9 %) each. According to the severity of osteodestructive syndrome, all patients were divided into 4 groups. The first group (0) included patients who did not have osteodestructive changes in the bones. In patients of the second group, a mild degree (I) osteodestructive process was observed, and in patients from the third and fourth groups – moderate (II) and severe (III) degrees, respectively. All patients underwent protein electrophoresis followed by immunofixation to determine the type of paraprotein and its concentration in serum and urine.Results. In the majority of patients, paraproteins were detected in the blood – Gκ (35.1 %), Gλ (24.6 %), Bence Jones protein λ-type (BJλ) (14.9 %); in urine – BJλ protein (14.9 %) and Bence Jones protein κ-type (BJκ) (28.1 %). Secretion of other types of paraproteins in the blood was less frequently detected – Aκ (9.6 %), Aλ (7.0 %), Mκ (3.5 %), Mλ (3.5 %), Dλ (2.6 %), BJκ (4.4 %). Osteodestructive syndrome of I and II severity was diagnosed in 43 (37.1 %) and 40 (34.5 %) patients, respectively; lytic destruction of III degree was less frequently detected in 20 (17.2 %) patients, in 13 (11.2 %) patients osteodestruction was not detected (degree 0). It was noted that a higher degree of destruction (II, III) was observed in patients with multiple myeloma occurring with paraproteinemia Dλ and BJλ in the blood, as well as hypercalcemia. Osteodestructive syndrome of the lowest degree (0, I) was diagnosed in patients with the secretion of monoclonal proteins Ak and Mλ. There was no statistically significant relationship between the type of secretion of paraproteins Gκ, Gλ, Aλ, Mκ, BJκ in the blood, as well as proteins BJκ and BJλ in the urine and the severity of the osteodestructive process.Conclusion. The results obtained in the study make it possible to identify risk groups, and parameters such as the type of paraprotein, the concentration of calcium in the blood serum can be considered as prognostic factors when assessing the severity of osteodestructive syndrome in patients with PH and WM.
Hematological response in patients with paroxysmal nocturnal hemoglobinuria treated with C5-inhibitor
Authors: Latyshev V. D. , Fidarova Z. T. , Ponomarev R. V. , Tsvetaeva N. V. , Mikhaylova E. A. , Lukina E. A. , Parovichnikova E. N. 
Published: January 2024

Background. Paroxysmal nocturnal hemoglobinuria is a rare clonal disease of the hematopoietic system, with the key manifestations of hemolytic anemia, a high thrombosis rate, and bone marrow failure. Despite the high efficacy of C5‑inhibitors in intravascular hemolysis cessation, a significant proportion of patients remain anemic. Causes of a sub‑optimal response may include C3‑mediated extravascular (intracellular) hemolysis, residual intravascular hemolysis, or bone marrow failure.Aim. To analyze the results of pathogenetic therapy in patients with paroxysmal nocturnal hemoglobinuria.Materials and methods. The study included 55 patients with paroxysmal nocturnal hemoglobinuria receiving complement C5 inhibitors for at least 6 months. Results. Suboptimal hematological response was observed in 31/55 (56 %) patients. The most common cause of anemia in the partial response group was C3‑mediated extravascular hemolysis in 8/10 (80 %), while bone marrow failure predominated (57 %) in the minor response group.Conclusion. The study showed a high frequency of suboptimal response to pathogenetic therapy and necessity of ac‑curate determination of leading cause of persistent anemia in order to modify therapy or switch to other drugs.
Earthquake Rupture Forecast Model Construction for the 2023 U.S. 50-State National Seismic Hazard Model Update: Central and Eastern U.S. Fault-Based Source Model
Authors: Shumway Allison M. , Petersen Mark D. , Powers Peter M. , Toro Gabriel , Altekruse Jason M. , Herrick Julie A. , Rukstales Kenneth S. , Thompson Jobe Jessica A. , Hatem Alexandra E. , Girot Demi L. 
Published: January 2024

Abstract
As part of the U.S. Geological Survey’s 2023 50-State National Seismic Hazard Model (NSHM), we make modest revisions and additions to the central and eastern U.S. (CEUS) fault-based seismic source model that result in locally substantial hazard changes. The CEUS fault-based source model was last updated as part of the 2014 NSHM and considered new information from the Seismic Source Characterization for Nuclear Facilities (CEUS-SSCn) Project. Since then, new geologic investigations have led to revised fault and fault-zone inputs, and the release of databases of fault-based sources in the CEUS. We have reviewed these databases and made minor revisions to six of the current fault-based sources in the NSHM, as well as added five new fault-based sources. Implementation of these sources follows the current NSHM methodology for CEUS fault-based sources, as well as the incorporation of a new magnitude–area relationship and updated maximum magnitude and recurrence rate estimates following the methods used by the CEUS-SSCn Project. Seismic hazard sensitivity calculations show some substantial local changes in hazard (−0.4g to 1.1g) due to some of these revisions and additions, especially from the addition of the central Virginia, Joiner ridge, and Saline River sources and revisions made to the Meers and New Madrid sources.
Outcomes of Whipple procedure/pancreaticoduodenectomy- an eighteen-year experience at a tertiary cancer care centre in south India
Authors: Shanmugam Subbiah , R. R. Pravenkumar 
Published: January 2024

Background: Early postoperative mortality rates after pancreaticoduodenectomy are in the range of 2-5%. Nonetheless, morbidity rates are still at 30-50% calling for apt strategies. The goal of this study was to examine the outcomes in terms of postoperative morbidity and 30-day mortality while additionally reviewing the demographic, clinical and pathological features of patients undergoing Whipple procedure at our government institution and comparing the outcomes with literature.
Methods: Data about demographic characteristics, intraoperative findings, postoperative histopathology, postoperative course, early post-operative outcomes, complications, and causes of postoperative death in patients who underwent pancreaticoduodenectomy for periampullary and pancreatic carcinoma between September 2006-August 2023 were collected and analysed.
Results: 45 patients were analysed. Mortality rate was 15.6%. Seven patients died perioperatively; three from cardiac cause (myocardial infarction), two from bile leak and sepsis, one from pulmonary embolism, and one as a result of postoperative hemorrhage. The morbidity rate was 54%. The most common early postoperative complication was delayed gastric emptying (31%) followed by postoperative pancreatic fistula (22%). The median overall survival of 39 patients was 21±6.5 months. The 5-year survival was 17 months.
Conclusions: Considering the fact that postoperative morbidity after Whipple procedure was similar to other centres, but the mortality rate being high, better knowledge about salvage techniques, improvements in perioperative care, use of interventional radiology, and running quality improvement projects to standardize postoperative recovery protocol could help in reducing the mortality and improve the outcome.
Management of idiopathic chylous peritonitis during laparoscopy: a case report and review of literature
Authors: Van Grinsven Vincent , Konsten Joop , Aarts Frits 
Published: January 2024

Chylous ascites is rare. Etiology can be traumatic, atraumatic or idiopathic. We present a case of idiopathic peritonitis managed by laparoscopic drainage and a medium-chain triglyceride diet. We present a case of a 60-year-old white female who presented to the emergency department with diffused abdominal pain, migrated from the back, and clinical signs of peritonitis. Blood works showed high leukocytosis, and computed tomography showed a large amount of intraperitoneal and retroperitoneal fluid. During an emergency laparoscopy, a chylous ascites was seen and drained, but a causing factor was not identified intraoperatively. Postoperatively, medium-chain triglyceride diet was initiated for a period of 6 weeks, cytological, microbiological and chemical analysis showed elevated levels of triglycerides in absence of other disease. Multiple diagnostic tests revealed no malignancy nor another underlying pathological processes. patient recovered well with no complications. When confronted with chylous ascites, surgeons should drain the abdomen and do thorough evaluation. When no cause is found intraoperatively, surgeons should not take aggressive measures but instead initiate a medium-chain triglyceride diet and search for underlying causes by means of further laboratory testing and positron emission tomography combined with computed tomography (PET-CT). When no etiology is found, medium-chain triglyceride diet can be stopped with no reports of recurrence.
An evidence-based approach to physical conditioning in American recruit law enforcement academies
Authors: Melton Bridget F. , Nagel Thomas , Landham Sarah , Anglin Derick , Ryan Gregory 
Published: January 2024

Background: Law enforcement physical fitness training is not standardized in the United States; instead, it relies heavily on training officers or other LEOs with an interest or background in exercise. The aim of the study was to evaluate performance outcomes between a traditionally designed physical conditioning program and an evidence-based conditioning program for law enforcement cadets.
Methods: Two metropolitan state law enforcement training centers in the southeast United States volunteered to participate in this investigation. Each academic program lasted 12 weeks and consisted of 5 days/week of physical training. The experimental group (n=46) was provided with an evidence-based physical conditioning program consisting of anaerobic and aerobic conditioning, agility, power, movement quality, defensive tactics, and muscular endurance.
Results: The control group participants (n=18) were assigned to a traditional instructor-led physical training program consisting of calisthenics and running. Of the 14 fitness variables measured, the intervention group displayed significant improvements in ten variables, whereas the control group significantly improved six.
Conclusions: The results of this study encourage law enforcement departments to make provisions for modifications to enhance traditional cadet physical training programs, with consultation from strength and conditioning subject matter experts.
Modeling and designing the features of inflow to a horizontal gas borehole fitted with coiled tubing within the filtering interval
Authors: Sokhoshko Sergey K. 
Published: January 2024

Relevance. The need to study the parameters of inflow (permeability rates, production inflow profile, flow rate along the horizontal wellbore) into the horizontal gas and gas condensate wellbores, when tubing is at the downhole zone. This allows scheduling well production rates, managing removal of water and mechanical impurities from the bottom-hole, carrying out well stimulation and completion activities, etc. Aim. To substantiate a mathematical model of the perforated horizontal gas borehole when the tubing shoe is within the perforation interval, as well as to calculate gas inflow parameters, flow rate along the wellbore and fluid permeability rates at the bottomhole zone of the wellbore. Object. Horizontal gas and gas condensate boreholes in anisotropic formations, methods for calculating gas inflow into perforated strings of horizontal boreholes, gas inflow rates and flow rates along the wellbore when tubing shoe is within the perforation interval. Methods. Modeling gas inflows into horizontal wellbores using a point source function, as well as the Leibenzon function; the use of local and hydraulic resistances theory in simulation of developing gas flow along the wellbore; determining gas inflow rates into the horizontal wellbore using the Reynolds number value. Results. The authors have carried out design calculation for the Bovanenkovskoe oil and gas condensate field using the model of gas inflow into a perforated horizontal (sloping) wellbore and analyzed the inflow parameters (flow velocity and permeability rates at the bottomhole zone, developing flow velocity along the wellbore) at various tubing shoe positions within the wellbore perforation interval. It was observed that when the tubing moves along the perforation interval the gas inflow to the wellbore can change from linear to non-linear. The authors made a conclusion that whenever extended periods of tubing positioning within the perforation interval is required, it is essential to select a low-pressure area which ensures a linear rate of gas inflow into the wellbore of a horizontal gas well.
Body Condition Score Versus Metabolites in Marwari Sheep under Cold Stress
Authors: Kumari Babita , Pareek Sunita , Maan Ruchi , . Gurvinder 
Published: January 2024

Background: The present study investigates the association between plasma metabolites and body condition score (BCS) in Marwari sheep under cold stress. BCS is considered as an easy, rapid and non-invasive assessment method for determining an animal’s state of health. Animals modify their body’s metabolic state to adapt and combat cold ambient temperature conditions. Methods: The present study was conducted on apparently healthy Marwari sheep by screening 180 animals from marginal farmers in two different ambiences from in and around Bikaner district of Rajasthan. The study included 6 months to 6 years age group animals which were divided in to six different categories as 2.0, 2.5, 3.0, 3.5, 4.0 and 4.5. The technique outlined by Jefferies (1961) and Russel (1968) was used to determine the body condition score of the sheep. Blood samples were collected during moderate and extreme cold ambiences in the morning hours from the slaughter house and health status was monitored by recording rectal temperature, respiratory rate and body condition score. Estimated plasma metabolites were glucose, total proteins, urea, cholesterol and creatinine. Result: The plasma glucose concentration increased significantly in extreme cold environment compared to a moderate environment (increasing by 9.21%), Whereas total plasma protein concentrations decreased significantly under cold conditions by 7.66%. Similarly, plasma urea and cholesterol levels increased significantly (8.81% and 13.81% increase, respectively). The results suggest that a particular BCS is not sufficient to represent the health state of sheep. However, animals with a BCS of 2.5 to 3.5 demonstrated strong physiological adaptability to their surroundings, indicating that Marwari sheep exposed to cold may have an ideal BCS.
Caracterización elemental con elipses tangentes a una recta y un círculo de la envolvente convexa de un cierto par de círculos.
Authors: Itzá Ortiz Benjamín A. , Rodríguez Torres Erika E. , Tetlalmatzi Montiel Margarita 
Published: January 2024

En este trabajo se presenta una caracterización de la envolvente convexa de los círculos (x-1)2 + y2 = 1/4 y (x+1)2 + y2 = 1/4 por medio de la unión de las elipses x2 + 5y2 + 4xy = 1/4 y la familia de las elipses centradas en el origen que, en cuatro puntos diferentes, son tangentes a dichos círculos y a los bordes superior e inferior de la envolvente convexa, empleando geometría analítica y derivación implícita.