Child Neurodevelopment After Multidomain Interventions From Preconception Through Early Childhood
Authors: Upadhyay Ravi Prakash , Taneja Sunita , Chowdhury Ranadip , Dhabhai Neeta , Sapra Savita , Mazumder Sarmila , Sharma Sitanshi , Tomlinson Mark , Dua Tarun , Chellani Harish , Dewan Rupali , Mittal Pratima , Bhan M. K. , Bhandari Nita ,   Women and Infants Integrated Interventions for Growth Study (WINGS) Group, Shekhawat Ratan , Siraj Sabreen , Nagpal Sugandhi , Abbasi Farah , Chaudhary Heena , Sharma Karishma , Rafiqui Farhana , Bhatia Kiran , Kaur Jasmine , Shekhar Medha , Kate Anita , Aggarwal Gunjan , Ghosh Runa , Kishore Kunal , Mehra Navneet , Arya Nikita , Chaudhary Ritu , Tamaria Anuradha , Kumar Tivendra , Karantha C Sowmya , Modi Purnima , Kaur Neelam , Tyagi Neha , Mehto Geeta , Khatun Afifa , Ahmed Sayeed , Singh Aparna , Ansari Gulafshan , Kaur Ramanjeet , Gupta Manisha , Pant Girish Chand , Dutta Ankita , More Deepak , Kumar Mukesh , Kuruvilla Sonia , Chandra Anjali , Debata Pradeep , Yadav Anita , Jain Abhinav , Sachdev Rahul , Bansal Omprakash , Agarwal Raghav 
Published: January 2024

ImportanceMultidomain interventions in pregnancy and early childhood have improved child neurodevelopment, but little is known about the effects of additional preconception interventions.ObjectiveTo evaluate the effect of a multifaceted approach including health; nutrition; water, sanitation, and hygiene (WASH); and psychosocial support interventions delivered during the preconception period and/or during pregnancy and early childhood on child neurodevelopment.Design, Setting, and ParticipantsIn this randomized trial involving low- and middle-income neighborhoods in Delhi, India, 13 500 participants were assigned to preconception interventions or routine care for the primary outcome of preterm births and childhood growth. Participants who became pregnant were randomized to pregnancy and early childhood interventions or routine care. Neurodevelopmental assessments, the trial’s secondary outcome reported herein, were conducted in a subsample of children at age 24 months, including 509 with preconception, pregnancy, and early childhood interventions; 473 with preconception interventions alone; 380 with pregnancy and early childhood interventions alone; and 350 with routine care. This study was conducted from November 1, 2020, through February 25, 2022.InterventionsHealth, nutrition, psychosocial care and support, and WASH interventions delivered during preconception, pregnancy, and early childhood periods.Main Outcomes and MeasuresCognitive, motor, language, and socioemotional performance at age 24 months, assessed using the Bayley Scales of Infant and Toddler Development 3 tool.ResultsThe mean age of participants at enrollment was 23.8 years (SD, 3.0 years). Compared with the controls at age 24 months, children in the preconception intervention groups had higher cognitive scores (mean difference [MD], 1.16; 98.3% CI, 0.18-2.13) but had similar language, motor, and socioemotional scores as controls. Those receiving pregnancy and early childhood interventions had higher cognitive (MD, 1.48; 98.3% CI, 0.49-2.46), language (MD, 2.29; 98.3% CI, 1.07-3.50), motor (MD, 1.53; 98.3% CI, 0.65-2.42), and socioemotional scores (MD, 4.15; 98.3% CI, 2.18-6.13) than did controls. The pregnancy and early childhood group also had lower incidence rate ratios (RRs) of moderate to severe delay in cognitive (incidence RR, 0.62; 98.3% CI, 0.40-0.96), language (incidence RR, 0.73; 98.3% CI, 0.57-0.93), and socioemotional (incidence RR, 0.49; 98.3% CI, 0.24-0.97) development than did those in the control group. Children in the preconception, pregnancy, and early childhood intervention group had higher cognitive (MD, 2.60; 98.3% CI, 1.08-4.12), language (MD, 3.46; 98.3% CI, 1.65-5.27), motor (MD, 2.31; 98.3% CI, 0.93-3.69), and socioemotional (MD, 5.55; 98.3% CI, 2.66-8.43) scores than did those in the control group.Conclusions and RelevanceMultidomain interventions during preconception, pregnancy and early childhood led to modest improvements in child neurodevelopment at 24 months. Such interventions for enhancing children’s development warrant further evaluation.Trial RegistrationClinical Trials Registry–India CTRI/2017/06/008908