bluuebunny/crossref_metadata_2025_split huggingface dataset:
MHD nonlinear natural convection from a uniformly moving porous vertical plate with constant heat and mass flux in the presence of thermal radiation, diffusion‐thermo, heat sink, and chemical reaction
Authors: Khanam Masuma , Ahmed Nazibuddin 
Published: December 2023

AbstractAn attempt has been made to investigate the problem of nonlinear free convection heat and mass transfer flow past an infinite vertical porous plate embedded in a porous medium by taking into account thermal radiation and heat sink with constant heat and mass flux. Transversely oriented and of uniform strength , a magnetic field has been introduced to the fluid area. The nonlinear density variation with temperature as well as concentration are the basis for the current physical situation, which is explained by this mathematical model. Exact solutions are derived for momentum equation, energy equation, and species continuity equation under the relevant boundary conditions. The dimensionless governing equations are analytically solved. The influence of various physical parameters, such as Dufour number, Schmidt number, thermal Grashof number, magnetic parameter, mass Grashof number, heat sink, thermal radiation, Prandtl number, chemical reaction parameter on the flow, and transport characteristic, has been presented graphically and in tabular form. The novelty of the present investigation is that here both constant heat and mass flux at the plate are taken into account in addition to thermal radiation and heat sink. The findings of the mathematical study demonstrate that velocity, temperature, and skin friction intensify with a rise in the Dufour number this is due to the fact that the convection current becomes stronger as the Dufour number rises. Fluid's concentration declines as the Schmidt number grows, or the concentration rises as the mass diffusivity rises. Fluid temperature is enhanced with high thermal diffusivity. Frictional resistance on the plate hikes due to thermal buoyancy force.
An empirical investigation of the relationship between brand value and firm value: Evidence from Turkey
Authors: Konuk Serhat , Doruk Ömer Tuğsal , Önal Yıldırım Beyazıt 
Published: December 2023

AbstractThis paper aims to investigate the relationship between brand value and firm value by using a two‐step approach. In the first step, we use the financial‐based brand valuation model (FBVEM) to obtain the brand value of firms that operated in the Turkish manufacturing industry during the period between 2014 and 2018. In the second step, we examine the effect of brand value on Tobin's Q. In doing so, we use a novel GMM, with a measurement errors model, which takes into account mismeasurements of the financial variables. We try to get an accurate estimation of the link between brand value and Tobin's Q in our analysis. The obtained findings show that the effect of brand value on firm value is positive in the Turkish manufacturing sector. Our results remain stable after robustness checks. This is the first well‐controlled study that considers the endogeneity problem and consequent measurement errors in the relationship between brand value and firm value.
Functional connectome hierarchy dysfunction in Alzheimer's disease and its relationship with cognition and gene expression profiling
Authors: Zheng Chuchu , Zhao Wei , Yang Zeyu , Guo Shuixia ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: December 2023

AbstractNumerous researches have shown that the human brain organizes as a continuum axis crossing from sensory motor to transmodal cortex. Functional network alterations were commonly found in Alzheimer's disease (AD). Whether the hierarchy of AD brain networks has changed and how these changes related to gene expression profiling and cognition is unclear. Using resting‐state functional magnetic resonance imaging data from 233 subjects (185 AD patients and 48 healthy controls), we studied the changes in the functional network gradients in AD. Moreover, we investigated the relationships between gradient alterations and cognition, and gene expression profiling, respectively. We found that the second gradient organizes as a continuum axis crossing from the sensory motor to the transmodal cortex. Compared to the healthy controls, the secondary gradient scores of the visual and somatomotor network (SOM) increased significantly in AD, and the secondary gradient scores of default mode and frontoparietal network decreased significantly in AD. The secondary gradient scores of SOM and salience network (SAL) significantly positively correlated with memory function in AD. The secondary gradient in SAL also significantly positively correlated with language function. The AD‐related second gradient alterations were spatially associated with the gene expression and the relevant genes enriched in neurobiology‐related pathways, specially expressed in various tissues, cell types, and developmental stages. These findings suggested the changes in the functional network gradients in AD and deepened our understanding of the correlation between macroscopic gradient structure and microscopic gene expression profiling in AD.
Catheter ablation of typical right atrial flutter in a 20‐day‐old neonate with tachycardiomyopathy
Authors: Leiria Tiago Luiz Luz , Cabral Israel Wolski , Schäfer Stephanie , Nicoloso Luiz Henrique Soares , Filho Raul Ivo Rossi , Kruse Marcelo Lapa , Saffi Marco Aurélio Lumertz , de Lima Gustavo Glotz 
Published: December 2023

AbstractBackgroundFetal echocardiography can diagnose neonatal atrial flutter, which can cause heart failure in newborns. Little is known about catheter ablation in this population.MethodsCase report that aimed to review a successful ablation in a 20‐day‐old patient with refractory atrial flutter.ResultsThis is the first report of a successful neonatal atrial flutter ablation without any early recurrence after the procedure.ConclusionsAtrial flutter ablation performed on newborns is a reliable and long‐lasting treatment option.
Preoperative optimization of the radical cystectomy patient: Current state and future directions
Authors: Ellis Jeffrey L. , Dalimov Zafardjan , Chew Lauren , Quek Marcus L. 
Published: December 2023

AbstractRadical cystectomy (RC) is associated with high rates of morbidity and mortality despite adoption of robotics and implementation of enhanced recovery after surgery protocols. There have been increased efforts to investigate preoperative optimization through comprehensive nutritional evaluation, preoperative supplementation, and prehabilitation outside of previously described enhanced recovery after surgery protocols to reduce mortality and morbidity from RC. In this review, we summarize and evaluate the current literature on preoperative assessment and optimization in RC.
Bioremediation of mercury contaminated soil and water: A review
Authors: Kumar Amit , Kumar Vinod , Chawla Mrinalini , Thakur Monika , Bhardwaj Renu , Wang Jianxu , O'Connor David , Hou Deyi , Rinklebe Jörg 
Published: December 2023

AbstractMercury (Hg) pollution of soil and water environments is a major global threat to human health, agri‐food systems and ecosystems and industrial activities mainly coal combustion augmented their content in different environmental media. Bioremediation is a nature‐based solution involving microbial‐ and plant‐based (phytoremediation) technologies that clean‐up Hg contaminated sites. Here, we review Hg‐resistant bacteria and how latest insights in our understanding of the cellular and biochemical mechanisms of the mer operon genes responsible for Hg resistance and transformation have facilitated developments in microbial Hg‐bioremediation. We also review the phytoremediation mechanisms, including those of bacterial‐ and fungi‐assisted phytoremediation processes, which have shown promising results in reducing Hg2+ to Hg0. This review provides a detailed knowledge of novel Hg bioremediation mechanisms and methods. Consequently, microbial‐ and phyto‐based bioremediation technologies have a critical role in the reclamation of Hg‐contaminated environments and the protection of human health and ecosystems.
Harnessing Macromolecular Chemistry to Design Hydrogel Micro‐ and Macro‐Environments
Authors: Soliman Bram G. , Longoni Alessia , Major Gretel S. , Lindberg Gabriella C. J. , Choi Yu Suk , Zhang Yu Shrike , Woodfield Tim B.F. , Lim Khoon S. 
Published: December 2023

AbstractCell encapsulation within three‐dimensional hydrogels is a promising approach to mimic tissues. However, true biomimicry of the intricate microenvironment, biophysical and biochemical gradients, and the macroscale hierarchical spatial organizations of native tissues is an unmet challenge within tissue engineering. This review provides an overview of the macromolecular chemistries that have been applied toward the design of cell‐friendly hydrogels, as well as their application toward controlling biophysical and biochemical bulk and gradient properties of the microenvironment. Furthermore, biofabrication technologies provide the opportunity to simultaneously replicate macroscale features of native tissues. Biofabrication strategies are reviewed in detail with a particular focus on the compatibility of these strategies with the current macromolecular toolkit described for hydrogel design and the challenges associated with their clinical translation. This review identifies that the convergence of the ever‐expanding macromolecular toolkit and technological advancements within the field of biofabrication, along with an improved biological understanding, represents a promising strategy toward the successful tissue regeneration.
Chimeric antigen receptor natural killer cells: a promising antitumor immunotherapy
Authors: Wang Yan , Jin Shengjie , Zhuang Qiqi , Liu Na , Chen Ruyi , Adam Sofia Abdulkadir , Jin Jie , Sun Jie 
Published: December 2023

AbstractChimeric antigen receptor (CAR) T cells have been successfully used in adoptive cell therapy for malignancies. However, some obstacles, including side effects such as graft‐versus‐host disease and cytokine release syndrome, therapy resistance, limited sources, as well as high cost, limited the application of CAR T cells. Recently, CAR natural killer (NK) cells have been pursued as the effector cells for adoptive immunotherapy for their attractive merits of strong intrinsic antitumor activity and relatively mild side effects. Additionally, CAR NK cells can be available from various sources and do not require strict human leukocyte antigen matching, which suggests them as promising “off‐the‐shelf” products for clinical application. Although the use of CAR NK cells is restrained by the limited proliferation and impaired efficiency within the immunosuppressive tumor microenvironment, further investigation in optimizing CAR structure and combination therapies will overcome these challenges. This review will summarize the advancement of CAR NK cells, CAR NK cell manufacture, the clinical outcomes of CAR NK therapy, the challenges in the field, and prospective solutions. Besides, we will discuss the emerging application of other immune cells for CAR engineering. Collectively, this comprehensive review will provide a valuable and informative summary of current progress and evaluate challenges and future opportunities of CAR NK cells in tumor treatment.
Musculoskeletal physiotherapists' discharge practices for people treated with low back pain: A United Kingdom survey
Authors: Smith Toby , Singh Gurpreet , Mcnamee George , Newton Christopher 
Published: December 2023

AbstractBackgroundPersistent low back pain (LBP) is the leading cause of disability, and a major burden on the healthcare system globally. Many people with LBP experience recurrent pain flares and receive repeated appointments and re‐referrals to services such as physiotherapy. However, it is not clear what the criteria are for discharging people with LBP from physiotherapy services. This study aims to describe the current practices for discharging people from physiotherapy for LBP in the United Kingdom (UK).MethodsA cross‐sectional study using an anonymous online national (UK) survey was conducted among qualified physiotherapists who treat people with LBP in UK musculoskeletal out‐patient services.ResultsA total of 104 surveys were completed. The majority of respondents reported using (i) a shared decision‐making (77%) and (ii) person‐physiotherapist goal attainment (74%) approach to discharging people with LBP. Sixty‐three percent of respondents reported using a patient‐initiated follow‐up (PIFU) approach. Only 8% of respondents reported using a graded discharge approach with ‘booster’ appointments. A PIFU or graded discharge approach was considered most pertinent for people at higher risk of a pain flare (97%; 86%) and with low self‐efficacy to self‐manage their LBP.ConclusionsThis UK survey established that discharge practices for people with LBP after physiotherapy vary. Whilst the majority of people are currently discharged with a PIFU appointment, a graded discharge approach may be more beneficial for people who are less likely to initiate a PIFU appointment. Further consideration on the development of such a pathway is now required.
Parameter identification of minifrac numerical tests using a gradient boosting‐based proxy model and genetic algorithm
Authors: Abreu Rafael , Mejia Cristian , Roehl Deane , Pereira Leonardo Cabral 
Published: December 2023

AbstractIn recent years, the petroleum industry has devoted considerable attention to studying fluid flow inside fracture channels due to the discovery of naturally fractured reservoirs. The behavior prediction of these reservoirs is a well‐known challenging task, in which the initial stage consists of identifying reservoir hydromechanical parameters. This work proposes an artificial intelligence‐based approach to identify hydromechanical parameters from borehole injection pressure curves acquired through minifrac tests. This approach combines proxy modeling with a stochastic optimization algorithm to match observed and predicted borehole pressure curves. Therefore, a gradient boosting‐based proxy model is built to predict borehole pressure curves, considering a proper strategy to develop time series modeling. Moreover, a Bayesian optimization algorithm is applied to compute the gradient boosting hyperparameters. In this optimization scenario, this paper proposes an appropriate objective function established from the assumed time series prediction strategy and the k‐fold cross‐validation. Finally, a genetic algorithm is adopted to identify unknown hydromechanical parameters, solving an inverse problem. Based on the proposed workflow, a study of the importance of the hydromechanical parameters is developed. To assess the methodology applicability, the approach is employed to identify parameters in synthetic and field minifrac tests. The results present how this approach can adequately identify hydromechanical parameters of hydraulic fracturing problems.
Nondestructive rapid identification of wild Cordyceps sinensis with portable instrument
Authors: Zhang Mengqi , Li Qin , Nie Lei , Hai Ping , Zhang Wei , Caiji Wangmao , Liang Wenyan , Zhang Hui , Zang Hengchang 
Published: December 2023

AbstractIntroductionCordyceps sinensis (CS) is a precious medicinal fungus. Wild CS (WCS) and artificial CS (ACS) are destroyed for their identification using traditional methods, which are time consuming and labor‐intensive. Therefore, it is crucial to establish a nondestructive identification method to rapidly screen WCS.ObjectiveThe aim of this study was to provide technical support for rapid screening of CS and evaluation of its quality. The applicability of the model was improved through model transfer.MethodsIn this study, continuous wavelet transform was used to analyze the differences in moisture content and active components between WCS and ACS from the perspective of characteristic molecular groups. A portable instrument and a laboratory benchtop instrument were used to determine CS spectra. Partial least squares discrimination analysis was conducted for the identification of WCS and ACS while preserving the original shape of CS. Moreover, improved principal component analysis was utilized to transfer the model between the two types of near‐infrared spectroscopy (NIRS) instruments.ResultsThe results demonstrated that three peaks, at 1443, 1941, and 2183 nm, were characteristic absorption peaks. The model based on NIRS could initially provide rapid differentiation between WCS and ACS. At the same time, the accuracy of the external test set was further improved to over 95% through forward transfer.ConclusionTherefore, this method could be used for rapid screening of WCS and provides technical support for the nondestructive identification of CS and initial assessment of CS quality.
The photovoltaic potential for electric vehicle charging along highways: A Dutch case study
Authors: Peerlings Jordi , Reinders Angèle , Catita Cristina , Brito Miguel Centeno 
Published: December 2023

AbstractThe large‐scale deployment of photovoltaics (PVs) along highways has the potential for the generation of clean electricity without competing for land use or burdening the power grid since energy for electric vehicles (EVs) can be generated locally on wastelands along highways near service stations. An analysis was carried out to evaluate the feasibility of integrating vertical bifacial solar modules into noise barriers. The approach involved integrating geospatial data with PV potential data using geographic information systems (GIS) technology. The results show a potential of around 200 GWh/year if all current noise barriers along highways in the Netherlands are considered suitable for PV module integration. Three case studies have been analysed regarding specific service stations for specific road orientations. It is shown that solar energy can charge more than 300 vehicles per day by combining bifacial PV noise barriers and standard mono‐facial PV modules on publicly available land along the highway in all three case studies, which is sufficient to meet 80% of the expected EV charging demand along highways in 2030.
Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles
Authors: Useckaite Zivile , Newman Lauren A. , Hopkins Ashley M , Klebe Sonja , Colella Alex D. , Chegeni Nusha , Williams Ruth , Sorich Michael J. , Rodrigues A. David , Chataway Tim K. , Rowland Andrew 
Published: December 2023

AbstractAdvances in technologies to isolate extracellular vesicles (EVs) and detect/quantify their cargo underpin the novel potential of these circulating particles as a liquid biopsy to understand physiology and disease. One organ of particular interest in terms of utilizing EVs as a liquid biopsy is the liver. The extent to which EVs originating from the liver reflect the functional status of this organ remains unknown. This is an important knowledge gap that underpins the utility of circulating liver derived EVs as a liquid biopsy. The primary objective of this study was to characterize the proteomic profile of EVs isolated from the extracellular space of liver tissue (LEV) and compare this profile to that of paired tissue (LH). LCMS analyses detected 2892 proteins in LEV and 2673 in LH. Of the 2673 proteins detected in LH, 1547 (58%) were also detected in LEV. Bioinformatic analyses demonstrated comparable representation of proteins in terms of biological functions and cellular compartments. Although, enriched representation of membrane proteins and associated functions was observed in LEV, while representation of nuclear proteins and associated functions was depleted in LEV. These data support the potential use of circulating liver derived EVs as a liquid biopsy for this organ.
The effects of inspiratory muscle training on cardiorespiratory functions in juvenile idiopathic arthritis: A randomized controlled trial
Authors: Sarac Devrim Can , Bayraktar Deniz , Ozer Kaya Derya , Altug Gucenmez Ozge , Oskay Deran 
Published: December 2023

AbstractIntroductionAlthough inspiratory muscle training (IMT) has proven effective in adult rheumatic diseases, its impact on juvenile idiopathic arthritis (JIA) remains unexplored. The present study aimed to investigate the effects of IMT in children with JIA.MethodsThirty‐three children (13–18 years) with JIA were divided into two groups as exercise (n = 17) and control (n = 16). The exercise group performed IMT at home daily for 8 weeks. The initial IMT load was set as 60% of maximal inspiratory pressure (PImax) and increased by %10 of the initial load every 2 weeks. The control group received no additional intervention. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FVC/FEV1, PImax, and maximal expiratory pressure (PEmax) were evaluated. Peak oxygen consumption (VO2max), metabolic equivalents (METs), and maximal heart rate were measured with cardiopulmonary exercise test. Functional capacity and quality of life were assessed with 6‐min walk distance and Pediatric Quality of Life Inventory 3.0 Arthritis Module. All participants were evaluated at baseline and post‐treatment.ResultsFVC ( ↑ 0.20 (95% CI: 0.07/0.32) liters), FEV1 ( ↑ 0.14 (95% CI: 0.02/0.25) liters), PImax (↑19.11 (95% CI: 9.52/28.71) cmH2O), PEmax (↑12.41 (95% CI: 3.09/21.72) cmH2O), VO2peak (↑158.29 (95% CI: 63.85/252.73) ml/min), and METs (↑0.92 (95% CI: 0.34/1.49) [ml/kg/min]) significantly improved only in the exercise group (p < .05). The difference over time in FVC, FEV1, PImax, VO2peak, and METs were significantly higher in exercise group compared to control group (p < .05).ConclusionsIMT seems to be an effective option for improving respiratory functions and aerobic exercise capacity in JIA.
Left ventricular underfilling in PAH: A potential indicator for adaptive‐to‐maladaptive transition
Authors: Guo Jiajun , Wang Jiaqi , Wang Lili , Li Yangjie , Xu Yuanwei , Li Weihao , Chen Chen , He Juan , Yin Lidan , Pu Shoufang , Wen Bi , Han Yuchi , Chen Yucheng 
Published: December 2023

AbstractPulmonary arterial hypertension (PAH) still remains a life‐threatening disorder with poor prognosis. The right ventricle (RV) adapts to the increased afterload by a series of prognostically significant morphological and functional changes, the adaptive nature should also be understood in the context of ventricular interdependence. We hypothesized that left ventricle (LV) underfilling could serve as an important imaging marker for identifying maladaptive changes and predicting clinical outcomes in PAH patients. We prospectively enrolled patients with PAH who underwent both cardiac magnetic resonance and right heart catheterization between October 2013 and December 2020. Patients were categorized into four groups based on their LV and RV mass/volume ratio (M/V). LV M/V was stratified using the normal value (0.7 g/mL for males and 0.6 g/mL for females) to identify patients with LV underfilling (M/V ≥ normal value), while RV M/V was stratified based on the median value. The primary endpoint was all‐cause mortality, and the composite endpoints included all‐cause mortality and heart failure‐related readmissions. A total of 190 PAH patients (53 male, mean age 37 years) were included in this study. Patients with LV underfilling exhibited higher NT‐proBNP levels, increased RV mass, larger RV but smaller LV, lower right ventricular ejection fraction, and shorter 6‐min walking distance. Patients with LV underfilling had a 2.7‐fold higher risk of mortality than those without and LV M/V (hazard ratio [per 0.1 g/mL increase]: 1.271, 95% confidence interval: 1.082–1.494, p = 0.004) was also independent predictors of all‐cause mortality. Moreover, patients with low LV M/V had a better prognosis regardless of the level of RV M/V. Thus, LV underfilling is an independent predictor of adverse clinical outcomes in patients with PAH, and it could be an important imaging marker for identifying maladaptive changes in these patients.