bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Development of Multi-Dimensional Plurality Bearing Cup Assembly and Disassembly Tool
Authors: Baladhandapani Vivek Aravind , Kandavel Arunachalam 
Published: October 2023

Abstract
Efficient and safe disassembly of bearing cups is a significant challenge in the automotive sector. This research article presents a novel design, analysis, and applications of a Plurality Bearing Cup Disassembly Tool (PBCDT). The PBCDT is a specialized tool developed to enable the simultaneous disassembly of multiple-bearing cups, addressing the needs of diverse industries, including automotive, aerospace, and heavy machinery. By eliminating the need for individual and stacking tools, the PBCDT overcomes the limitations of existing disassembly techniques, such as local weld and hit practices commonly used in workshops. This article presents a detailed design, with a focus on critical factors like material selection and manufacturing techniques. Structural analysis utilizing Finite Element Analysis (FEA) is conducted to ensure the robustness and durability of the tool. Furthermore, the article explores the ergonomic aspects and user-friendliness of the PBCDT, emphasizing the importance of operator comfort and efficiency during disassembly operations.The insights provided in this research article regarding the design, analysis, and potential applications of the PBCDT serve as a valuable resource for engineers, technicians, and researchers engaged in bearing cup disassembly operations. By employing the PBCDT, professionals can improve productivity, reduce disassembly time, and eliminate the risks associated with traditional disassembly methods.
Life after medicalised conception: An interpretative phenomenological analysis study exploring the experiences of pregnancy and early parenting
Authors: Foyston Zoe , Higgens Lucy , Smith Debbie , Wittkowski Anja 
Published: October 2023

Abstract

Background
Pregnancy resulting from Medicalised Conception (MAC) is increasingly prevalent. In-Vitro Fertilisation (IVF) is the most common type of treatment which has been linked to increased pregnancy-specific anxiety and different approaches to parenting. This study was novel in exploring the lived experiences of pregnancy and early parenthood in individuals who conceived via IVF, identifying how they coped with any psychological difficulties.
Method
Twelve UK participants, who successfully achieved pregnancy via IVF and had given birth to an infant aged 12 weeks to 2 years old currently, were interviewed. Semi-structured interviews were audio-recorded, transcribed and analysed using Interpretative Phenomenological Analysis.
Results
Three superordinate themes were identified: 1) The lasting imprint of IVF: unidentified and unmet psychological needs. The resultant loss, grief and powerlessness associated with the IVF treatment process left individuals emotionally vulnerable entering pregnancy. The lasting impact of IVF was evident, influencing birth preferences and feeding choices. 2) The fragility of pregnancy: helpless and existing in a world of uncertainty. Pregnancy was often approached with caution and trepidation, leading to methods of self-protection, such as difficulties in believing the existence of the pregnancy. 3) The parental function of healthcare systems: needing an anchor and a sense of safety highlighted the pivotal role of health systems and their ability to perpetuate or alleviate distress.
Conclusions
The psychological vulnerability of expectant parents needs to be considered throughout the perinatal period. Routine monitoring of psychological well-being and the implementation of specialist services and peer support for individuals who conceive via IVF is recommended.
The first modified mercalli intensity map of Maku, NW Iran
Authors: UCHTAPEH MOHAMMAD SADEGH MAMSEYDE , AKASHE BAHRAM , POURKERMANI MOHSEN , GHEITANCHI MOHAMMAD REZA , Dorostian Arezou , JARAHI HADI 
Published: October 2023

Abstract
The aim of this study is to provide a probabilistic modified Mercalli intensity (PMMI) map based on seismological studies for the Maku Quadrangle. The study area is located in the NW corner of Iran. The occurrence of several destructive earthquakes and the existence of active faults represent a high level of seismicity in this area. While investigating the seismotectonics and b-value, all active seismic sources were identified and the seismic parameters were calculated for those. Then the PMMI map was calculated using four attenuation equations. The results showed that the maximum intensity is in the form of a strip running NW-SE and showed good compatibility with the Iğdır and Balıkgölü faults. The present results are in good agreement with the shake map of earthquakes which occurred in the region.
An application of Atorvastatin to anti - fungal effects in acute myeloid leukemia: a multicenter, triple-blinded, randomized clinical trial
Authors: Saber-moghaddam Niloufar , nodeh Mohammad Moeini , Ghavami Vahid , Rahimi Hossein , azimi Sajjad Ataei , Seddigh-shamsi Mohsen , Kamandi Mostafa , Allahyari Abolghasem , maghani Somayeh Shariat , Elyasi Sepideh , Arasteh Omid 
Published: October 2023

Abstract
Background:
The development of invasive fungal infections (IFIs) is a serious complication in Acute myeloid leukemia (AML) patients who undergo an induction to remission chemotherapy. Given the increased mortality in AML patients with IFI despite prophylaxis, we need to solve this problem. Statins have traditionally been employed in the clinical setting as agents for reducing lipid levels. Nonetheless, recent investigations have brought to light their antifungal properties in animals, as well as in-vitro studies.
Objectives:
The objective of this study was to assess the effectiveness of Atorvastatin in the treatment of invasive fungal infections in patients diagnosed with acute myeloid leukemia.
Methods:
A randomized, multicenter, triple-blind study was conducted on 76 AML patients aged 18-70, who received either placebo or Atorvastatin in addition to Fluconazole. Patients were followed for 30 days in case of developing IFIs, patients’ survival and Atorvastatin related adverse drug reactions. Data have been analyzed with SPSS version 26.0. A level of significance of 0.05 was utilized as the threshold for all statistical tests.
Results:
The data were analyzed by adjusting for the effect of age, regarding that there was a significant difference between the two groups, and showed that Atorvastatin reduced the development of both probable and proven IFI (based on EORTC/MSGERC criteria) compared to placebo. IFI-free survival was also significantly better in the Atorvastatin group. The incidence of developing Aspergillosis did not differ between the two groups. No serious adverse events related to Atorvastatin were seen.
Conclusion:
The present investigation has substantiated the antecedent in-vitro and animal research on the fungicidal impact of statins and has suggested the need for additional research involving larger sample sizes and an extended duration of follow-up.
Predicting Acute Chest Syndrome Risk in Sickle Cell Anemia Children During Vaso-occlusive Crisis Hospitalizations
Authors: Alghamdi Faisal , Al-Kasim Fawaz , Obied Forat , Gharieb Etedal , Azmet Fauzia , Almudaibigh Adel , Baitalmal Lobna , Alnawfal Beddah , Alluqmani Rehab 
Published: October 2023

Abstract
Sickle cell anemia (SCA) is a globally prevalent inherited condition, with acute chest syndrome (ACS) being one of its most severe complications. ACS frequently leads to hospitalization, necessitates intensive care unit (ICU) admission, and can even result in death. This research aimed to discern early indicators of impending ACS in children with SCA who were initially hospitalized due to painful vaso-occlusive crises (VOC). A retrospective, case-control investigation was carried out at the King Saud Medical City in Riyadh, Saudi Arabia, encompassing 120 patients aged 1 to 14 years from January 2021 to December 2022. Patients were classified into two groups: those who developed ACS during hospital stay (cases) and those who did not develop ACS (controls). The study compared demographic factors, laboratory results, vital and clinical signs, and treatment protocols between these groups. Findings revealed that a previous diagnosis of asthma, a history of ACS, recent upper respiratory tract symptoms prior to admission, and the need for a blood transfusion within the first 24 hours of admission due to a drop in hemoglobin levels were all significant predictors of impending ACS. Further regression analysis indicated that elevated steady-state mean corpuscular volume (MCV), leukocyte count, total bilirubin, and an increased absolute neutrophil count (ANC) level 24 hours post-admission also foreshadowed impending ACS in patients admitted for VOC. Additionally, the location of pain was found to be significant with ACS incidence being higher in patients experiencing back pain, while patients with pain confined to the limbs had a lower incidence of ACS during admission. The average duration of hospital stay was notably longer for the ACS group, averaging 7.6 days compared to 5.8 days for VOC alone. 15.7% of patients initially admitted with VOC were diagnosed with ACS. Most ACS cases were managed with transfusions and antibiotics, and nearly one-third of patients required admission to an ICU or high dependency area.
S9.6-based hybrid capture immunoassay for pathogen detection
Authors: Bothra Ankur , Perry Megan , Wei Elena , Moayeri Mahtab , Ma Qian , Biamonte Marco , Siirin Marina , Leppla Stephen 
Published: October 2023

Abstract
The detection of pathogens is critical for clinical diagnosis and public health surveillance. Detection is usually done with nucleic acid-based tests (NATs) and rapid antigen tests (e.g., lateral flow assays [LFAs]). Although NATs are more sensitive and specific, their use is often limited in resource-poor settings due to specialized requirements. To address this limitation, we developed a rapid DNA-RNA Hybrid Capture immunoassay (HC) that specifically detects RNA from pathogens. This assay utilizes a unique monoclonal antibody, S9.6, which binds DNA-RNA hybrids. Biotinylated single-stranded DNA probes are hybridized to target RNAs, followed by hybrid capture on streptavidin and detection with S9.6. The HC-ELISA assay can detect as few as 104 RNA molecules that are 2.2 kb in length. We also adapted this assay into a LFA format, where captured Bacillus anthracis rpoB RNA of 3.5 kb length was detectable from a bacterial load equivalent to 107 CFU per 100 mg of mouse tissue using either HC-ELISA or HC-LFA. Importantly, we also demonstrated the versatility of HC by detecting other pathogens, including SARS-CoV2 and Toxoplasma gondii, showing its potential for broad pathogen detection. Notably, HC does not require amplification of the target nucleic acid and utilizes economical formats like ELISA and LFA, making it suitable for use in sentinel labs for pathogen detection or as a molecular tool in basic research laboratories. Our study highlights the potential of HC as a sensitive and versatile method for RNA-based pathogen detection.
Unexpectedly detected high-grade plasma fallopian tube cancer: a case report
Authors: Zhou Juanhong , Ma Xinyun , Chen Fan , Fu Jiaojiao , Zhu Jiaojiao , Liu Xiaofeng , Liu Huiling 
Published: October 2023

Abstract
Primary fallopian tube cancer is a rare gynecologic malignancy that accounts for only a small percentage of cases. It can present with nonspecific symptoms such as abdominal pain, vaginal discharge, and pelvic mass, making accurate diagnosis challenging. Confirmation of the disease relies on postoperative histopathology and immunohistochemical staining. The article presents a case of an elderly woman who was diagnosed with primary fallopian tube cancer after undergoing hysterectomy for abnormal uterine bleeding. The patient's subsequent chemotherapy treatment resulted in a positive prognosis, highlighting the importance of clinical diagnosis and management of this rare cancer. Early detection, surgical resection, chemotherapy, and close follow-up are crucial for improving diagnosis and preventing recurrence. Further research is needed to better understand the pathogenesis of primary fallopian tube cancer.
Facilely prepared carbon dots as effective anode modifier for enhanced performance of microbial fuel cells
Authors: Wei Hui-Xu , Qiu Rui , Li Ai-Yi , Liang Liu-Jie , Feng Yan-Nan , Li Shu-Hua , Li Nan 
Published: October 2023

Abstract
Microbial fuel cells (MFCs) are a promising technology for obtaining energy in wastewater. Effective extracellular electron transfer is one of the key factors for its practical application. In this work, carbon dots (CDs) enriched with oxygen-containing groups on the surface were synthesized as an efficient anode modifier using a simple hydrothermal method and common reactants. The experimental results showed that CDs-modified anodes had higher electrical conductivity, and higher hydrophilicity, could load more microorganisms, enhanced electrochemical processes in the anode biofilm, and did not affect the total content of electrobacteria in the biofilm. The CDs-modified MFCs exhibited higher maximum power density (661.1 ± 42.6 mW m− 2) and open-circuit voltage (534.50 ± 6.4 mV), which were significantly better than those of the blank group MFCs (484.1 ± 14.1 mW m− 2 and 447.50 ± 12.1 mV). The use of simple carbon materials to improve the microbial loading on the MFCs anode and the electron transfer between the microbial-electrode may provide a new idea for the design of efficient MFCs.
Does boundary solutions of the Lucas endogenous growth model explain why some countries are not accumulating human capital?
Authors: Bella Giovanni , Kogan Konstantin , Mattana Paolo , Tsadikovich Dmitry , Venturi Beatrice 
Published: October 2023

Abstract
Recent data from World Bank provides evidence that there is a surprisingly large cluster of countries which have not been accumulating human capital since long time. This paper shows that this phenomenon is not necessarily at odds with the Lucas’ model (1988) of endogenous growth, provided that available time is relatively more productive in the goods-producing sector than in the schooling sector, even when all available effort is already committed to work (boundary solution). We also discuss sufficient conditions for the economy to enter a regular regime, starting to also accumulate human capital (interior solution). The elasticity of intertemporal substitution is a particularly relevant element able to shortens the no-human capital accumulation period: other things being equal, the more the economy values future, the quicker the economy is able to jump onto a transient orbit converging to the BGP.
Research on the anatomical application of robot and 3D guide-assisted lumbar cortical bone trajectory screw placement technique
Authors: Maimaiti Abulikemu , Xiao Yang , Zhang Rui , Dadihan Tursunjiang , Wang Yixi , Maitusong Muzaipaer , Sheng Weibin , Rexiti Paerhati , Cao Li 
Published: October 2023

Abstract
Background: To compare the accuracy of robotic and 3D guide-assisted cortical bone trajectory (CBT) screw placement in lumbar spine in human cadaver wet specimens.
Methods:Six lumbar cadaver specimens were included. The left and right sides of L1-L5 vertebrae were randomly selected for screw placement using two techniques. Evaluation of preoperative planning time, intraoperative injury level and postoperative screw placement accuracy, number of cortical bone contact layers, and facet joint invasion rate were performed for two surgical techniques.
Results: A total of 60 screws were implanted. The accuracy of robot-assisted screw placement with 93% were significantly higher than 3D guide-assisted screw placement with 97% (15 screws with level 0, 13 screws with level 1, and 2 screws with level 2). The average number of cortical bone contact layers on the robot-assisted and 3D guide-assisted screw placement side were 4.6 and 4.1 (P<0.05). Four screws on the robot-assisted side were grade 2, and the remaining 26 screws were grade 0. The facet joints invasion rate was 13.3%. Two screws on the 3D guide-assisted side were grade 2, and the remaining 28 screws were grade 0, facet joints invasion rate was 6.7%. There was no statistical difference in facet joint invasion rate between the two screw placement methods (P>0.05).
Conclusion:Robot-assisted screw placement is more accurate, safe, and minimally invasive than 3D guide plate-assisted screw placement. It has advantages over 3D guide plate-assisted screw placement in terms of cortical bone contact, and can further increase the screw-holding force.
Concordance between two monoclonal antibody (mAb)-based enzyme-linked immunosorbent assays for the measurement of cysticercal antigen levels in sera of pigs experimentally infected with Taenia solium and Taenia hydatigena
Authors: Arroyo Gianfranco , Toribio Luz , Garrido Sara , Chile Nancy , Lopez-Urbina Teresa , Gomez-Puerta Luis A. , Muro Miguel , Gilman Robert H. , Castillo Yesenia , Dorny Pierre , O’Neal Seth E. , Gonzalez Armando E. , Garcia Hector H. 
Published: October 2023

Abstract
Background
Antigen detection in Taenia solium cysticercosis confirms viable infection in the intermediate host (either pig or human). The reference B158 / B60 antigen-detection ELISA (Ag-ELISA) has high levels of sensitivity and specificity in human neurocysticercosis (94% and 99% according to the manufacturer), although its sensitivity is lower in cases with single brain cysts, whereas in porcine cysticercosis the assay performance is affected by its frequent cross-reaction with Taenia hydatigena. Our group has produced 21 anti-T. solium monoclonal antibodies (mAbs) reacting against antigens of the whole cyst, vesicular fluid, and secretory/excretory products, identifying TsW8 / TsW5 as the most promising pair of mAbs for an Ag-ELISA.
Methods
We report the use of our TsW8 / TsW5 Ag-ELISA for the measurement of parasite antigen levels in two panels of sera from pigs experimentally infected with T. solium (n = 26) and T. hydatigena (n = 12) from day 0 to day 90 post-infection (PI) and assessed the concordance of our assay with the reference B158 / B60 Ag-ELISA using Bland-Altman (BA) plots and Lin’s concordance coefficients (LCC).
Results
Our TsW8 / TsW5 Ag-ELISA measured antigen levels efficiently during the course of T. solium cysticercosis infections in pigs with a strong agreement with the reference B158 / B60 Ag-ELISA in almost all paired log-transformed optical density (OD) values. The limits of agreement (LoA) in the BA plot at days 0, 28, and 90 PI were 92.3%, 100% and 100%, respectively, and high concordance between assays was also found (LCC: 0.69, 0.92, and 0.96, respectively, all P < 0.001). In pigs infected with T. hydatigena, almost all paired log-transformed ODs were also within the LoA, whereas concordance between assays was low or moderate at days 0 and 28 PI, (LCC: 0.24 and 0.88), but higher at day 90 PI (LCC: 0.98, P < 0.001).
Conclusions / significance:
The TsW8 / TsW5 Ag-ELISA recognizes antigens in pigs with T. solium cysticercosis and is highly concordant with the B158 / B60 Ag-ELISA. However, its diagnostic use is hampered by cross-reactions with T. hydatigena, as in other mAb antigen detection assays.
Metabolomics approach to explore bioactive natural products derived from plant-root-associated Streptomyces
Authors: KUM Ekrem , Ince Ebru 
Published: October 2023

Abstract
Streptomyces, a prominent genus within the Actinobacteria phylum, is responsible for over 60% of clinically relevant antibiotics. Streptomyces strains inhabiting plant roots possess the potential to synthesize bioactive natural products, conferring defense and resilience to plants against pathogenic microorganisms. However, this potential remains largely unexplored. This study aims to screen for bioactive metabolites produced by Streptomyces strains in the plant rhizosphere.
Six Streptomyces isolates were cultivated using three modified media to induce the production of diverse metabolites, employing the OSMAC (One Strain Many Compounds) approach. Metabolite profiles of extracts from fermentation broths were analyzed using a non-targeted LC-MS/MS approach combined with GNPS molecular networking. The antimicrobial activity of the extracts was assessed using the disc diffusion method.
The strains exhibited a broad-spectrum antimicrobial activity against all tested organisms, with particularly pronounced inhibition observed against Gram-positive bacteria and Candida albicans, resulting in inhibition zones exceeding 30 mm. Within the metabolomes of these strains, the antibiotics spiramycin and actinomycin were detected. Additionally, lyngbatoxin, a tumor promoter, and potential new analogs were identified. Notably, a substantial portion of the generated metabolites did not match any known compounds, implying the presence of unidentified metabolites produced by these strains, which could potentially introduce novel chemical entities.
This study illuminates the potential for discovering bioactive compounds from Streptomyces strains associated with plant roots, offering valuable insights for antimicrobial drug development. Furthermore, the metabolomics approach utilized in this study serves as a rapid and valuable tool for the screening of microorganisms capable of producing bioactive metabolites.
Considerations on cataract surgery in wet Age-related Macular Degeneration (wAMD)
Authors: Vingolo Enzo Maria , Nebbioso Marcella 
Published: October 2023

Abstract
Background: Cataract and Age-related Macular Degeneration are two characteristic diseases of the so-called elderly age (75-90 years and older). Both determine an important visual impairment, so it is often difficult to understand how much of the visual loss is given by the cataract opacities and how much by the degeneration of the macula and this assumes a relevant medico-legal query in clinical practice.
Methods: From that pool we randomized in group A 735 eyes with wAMD (males 328, females 407) Average age: 76.23±13.87 years, and in Group B 819 eyes without clear signs of wAMD (males 361, females 451) Average age: was 75.88±18.21 years to randomize them we used the online randomization program (http://www.graphpad.com/quickcalcs/index.cfm) selecting random numbers and then randomly assign subjects to groups to undergo our observational study. All patients were examined with full ophtalmological visit including Best Corrected Visual Acuity (with Bailey-Lawson Chart), Anterior Segment examination, Fundus Examination, in all cases with wAMD was also performed OCT.
Results: number of patients with unsatisfactory surgery is significantly higher in the group of AMD patients, and this is easily understandable from what has been said above, but I would like to underline that in most patients there are very positive results, therefore cataract surgery is also indicated in AMD patients.
Conclusions: Cataract surgery has a positive impact on the patient's life in most cases, you shouldn't be afraid to operate. However, it is necessary to find surgical measures capable of minimizing the consequences of the intervention on the retina.