bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-proliferative and Pro-apoptotic Activity of a Novel Oil-in-Water Nanoemulsion Containing Tea Tree Oil, Quercetin, and Rosmarinic Acid in Breast Cancer Cells
Authors: Medina-Magariño Esther de J. , Pinos-Rodríguez Juan M. , Pulido-Capiz Ángel , García-González Víctor , Torres-Maravilla Edgar , Quiroz-Mercado Joaquín A. , Cano-Sarmiento Cynthia 
Published: January 2025

Abstract
Cancer is one of the main causes of death across major mammalian orders, being the mammary gland tumor the most frequent in females. Surgery is the most widely used prescription for this condition; however, due to its side effects, new and less invasive treatments using bioactive compounds are being sought. Nanostructured systems, such as nanoemulsions (NEs), enable more efficient delivery and protection of these compounds, allowing it to reach its site of action more effectively. The present study aimed to develop oil-in-water (O/W) NEs with tea tree essential oil integrating quercetin, rosmarinic acid, or both and evaluate them as potential therapeutic agents in breast cancer cells. The NEs were characterized by particle size distribution and Z-potential for 4 weeks. Subsequently, their impact on cell viability was assessed in MDA-MB-231 cells, a triple-negative breast cancer cell line. The four NEs had an average size within the nanometer scale (10–9 m), ideal to passive target the anticancer effect (< 200 nm) due to the retention effect and facilitate its permeability. These vehicles were kept stable at 4 °C for 4 weeks. Our findings demonstrate that with initial doses of 3.9 μg/mL of these NEs, significant antiproliferative activity is achieved in cancer cells (~ 80%, p < 0.001); furthermore, the induction of apoptosis through caspase activation was demonstrated in MDA-MB-231 cells. In summary, our preliminary results suggest that nanoemulsions (NEs) of tea tree oil incorporating the bioactive compounds uercetin and rosmarinic acid may have potential therapeutic applications as co-adjuvant treatment of human breast cancer.
Unravelling the Potential of Anticancer Drugs for SARS-CoV-2
Authors: Low Zheng Yao , Wong Ka Heng , Yip Ashley Jia Wen , Liew Hern Liang , Farouk Isra Ahmad , Lal Sunil Kumar , Choo Wee Sim 
Published: January 2025

Abstract

Purpose of Review
Concerning the COVID-19 pandemic, repositioning several anticancer drugs has modulated SARS-CoV-2-induced inflammatory responses and disrupted viral replication. This review aims to discuss the potential of anticancer drug repositioning (DR) for anti-SARS-CoV-2 RdRp, its limitations, and other notable successes of DR against COVID-19.

Recent Findings
The emergence of SARS-CoV-2, an etiological agent that accounted for the current chaotic COVID-19 episode, has brought many lives away. Notably, the viral RNA-dependent RNA polymerase (RdRp) has contributed significantly to the viral replication of all RNA viruses, including SARS-CoV-2, making it a promising target for drug treatment. The lack of efficacious drugs combined with the prolonged duration of the drug discovery process has prompted many to opt for drug repositioning (DR) as an alternative route to combat current or emerging diseases. The human telomerase reverse transcriptase (hTERT), a telomerase catalytic subunit in cancers, has been identified with functional and structural similarities to the viral RdRp, making it a potential target to explore drug repositioning of current anticancer drugs for antiviral usage.

Summary
Taken together, the investigation of hTERT and other anticancer drugs is essential to explore other uses of existing drugs for COVID-19, especially in such an urgent time of need. This review highlights the prospects of repositioning anticancer drugs against COVID-19 and its limitations.
Bridges monitoring and assessment using an integrated bim methodology
Authors: Rodriguez Polania D. , Tondolo F. , Osello A. , Piras M. , Di Pietra V. , Grasso N. 
Published: January 2025

Abstract
Risk assessment of long-existing infrastructure has become one of the main challenges in civil engineering. Major efforts have been made in recent years to develop new techniques for rapid damage identification and ensure proper management of these structures. This paper presents a data management approach utilizing BIM methodology to create a digital database for bridge monitoring procedures. Initially, two BIM methodologies for creating a damage database are introduced, focusing on beams from a dismantled urban viaduct. Subsequently, the most suitable methodology is applied to an existing bridge in Turin, Italy. Through the chosen methodology a damage identification and classification process based on a triangular mesh is performed, assisted by a convolutional neural network (CNN) for automatic damage detection. Additionally, the paper outlines a digitalization process within a BIM environment, integrating official guidelines for bridge risk evaluation, classification, and monitoring in Italy. By employing programming tools, all data required by the guidelines is efficiently incorporated into the database. The outcomes demonstrate the effectiveness of remote sensing applications for bridge inspection and the possibility of merging BIM methodology into the inspection process to enhance the damage assessment of existing structures.
Evaluating Deep Learning Advances for Point Cloud Semantic Segmentation in Urban Environments
Authors: Yan Hailun , Lau Albert , Fan Hongchao 
Published: January 2025

Abstract
The rapid evolution of deep learning technologies has substantially influenced the field of urban-scene point cloud semantic segmentation (USPCSS), a cornerstone for various applications ranging from road-level applications such as autonomous driving, traffic management, and railway track inspection to urban-level applications such as disaster management, urban planning, and rail infrastructure monitoring. Despite remarkable progress, the complexity of urban environments presents unique challenges. This study conducts an in-depth review of both state-of-the-art and pioneering deep learning models and datasets specifically tailored for USPCSS. First, we categorize the existing mainstream USPCSS datasets into road-level and urban-level, summarize their metadata and unique characteristics, and discuss their associated challenges in semantic segmentation. Second, we classify the USPCSS deep learning models into four categories—image-based, voxel-based, point-based, and fusion-based—highlighting unique strengths and weaknesses, architectures, and innovations. Third, we introduce the mainstream USPCSS evaluation metrics, and conduct comparative analyses of these models on selected datasets. Findings reveal that the recent point-based methods such as PTv3 significantly dominate the accuracy metrics across road-level benchmarks, indicating the robustness of using transformer-based architectures for the direct processing of complex urban-scene point clouds. In the end, we address the pressing challenges and gaps in current research, offering insights into future directions for advancing the USPCSS field. Through this review study, we aim to provide thorough guidance to researchers, engineers, and decision-makers who are seeking comprehensive understanding and cutting-edge solutions in the current field of USPCSS.
Megaproject responsible innovation: Concept, framework, and governance
Authors: Lin Han , Nie Shangyao , Wu Pingping , Yuan Ming , Yu Mingchuan , Tam Vivian 
Published: January 2025

Abstract
The reliability and sustainability of innovation in megaprojects are of critical importance with complex stakeholders and substantial resource investments. In that respect, responsible innovation management is the key to the sustainable development of megaprojects. This paper proposes the concept of megaproject responsible innovation (MRI) and develops a holistic framework for MRI with four dimensions: (1) anticipation across the megaproject life cycle, (2) inclusion of various parties in a relationship of symbiosis, competition, and cooperation, (3) reflexivity of social responsibility, and (4) responsiveness to social expectations. Based on an ecosystem approach to megaproject innovation, we propose an ecological governance strategy for MIR. Moreover, different approaches are needed in innovation organizations which are part of specific ecological niches for effective and efficient governance.
Violence, change and continuity in times of transition
Authors: Schwarz Alexander W. , Kühn Florian P. , Eichenberg Julia 
Published: January 2025

Abstract
This article discusses how analyses of conflict often overlook competing interpretations of violence in times of change and transition. As a result, in historiography as well as in public discourse, wars just ‘end’ while neglecting the phenomena that are overlapping war and peaceful periods. This article argues that, along the dimensions of state domination, economy and law, alternative periodizations are required to do justice to actors whose politics are often not very strategic yet important for the political dynamics of transitions. Violence, we argue, can be used as a marker and entry point into the complex politics of change, which are motivated by ideology, opportunity, societal dynamics and lack of coherent control by the state or other institutions.
Plant metabolomics: applications and challenges in the era of multi-omics big data
Authors: Hao Yingchen , Zhang Zhonghui , Luo Enxi , Yang Jun , Wang Shouchuang 
Published: January 2025

Abstract
Plant metabolites are crucial for the growth, development, environmental adaptation, and nutritional quality of plants. Plant metabolomics, a key branch of systems biology, involves the comprehensive analysis and interpretation of the composition, variation, and functions of these metabolites. Advances in technology have transformed plant metabolomics into a sophisticated process involving sample collection, metabolite extraction, high-throughput analysis, data processing, and multidimensional statistical analysis. In today’s era of big data, the field is witnessing an explosion in data acquisition, offering insight into the complexity and dynamics of plant metabolism. Moreover, multiple omics strategies can be integrated to reveal interactions and regulatory networks across different molecular levels, deepening our understanding of plant biological processes. In this review, we highlight recent advances and challenges in plant metabolomics, emphasizing the roles for this technique in improving crop varieties, enhancing nutritional value, and increasing stress resistance. We also explore the scientific foundations of plant metabolomics and its applications in medicine, and ecological conservation.
Education for sustainable development: analyzing research trends in higher education for sustainable development goals through bibliometric analysis
Authors: Tafese Mestawot Beyene , Kopp Erika 
Published: January 2025

Abstract
Education is a critical component in the advancement of global sustainable development. In recent years, there has been a notable increase in research output within higher education institutions dedicated to this pivotal area. This study aims to identify emerging trends in higher education research on sustainable development goals and examine the specific focus areas in which researchers are engaged. A comprehensive bibliometric analysis was conducted on scholarly articles on education for sustainable development (ESD), utilizing data from the Scopus database. 2221 documents were extracted from the database of scientific articles published between 1990 and 2023. After a thorough screening, 1013 articles met the eligibility criteria and were subsequently analyzed using the R-Studio software platform. The findings indicate a significant increase in scientific output in this area since 2018, peaking in 2022 and then declining in 2023. The most prominent journal in this field is Sustainability, published in Switzerland. Gericke is identified as the most prolific author, followed by notable contributions from Leal and Kopnina, who have the highest H-index impact. Regarding publication volumes, China, Spain, and Germany are the leading countries. Thematic analysis revealed a predominant emphasis on the environmental and economic dimensions of sustainable development, with a comparatively less focus on social sustainability. This imbalance has significant implications, as social sustainability is critical to achieving societal stability. The findings of this research highlight the necessity for a comprehensive approach to higher education research that considers social sustainability, intending to promote a more holistic and enduring sustainability in the future.
Systematic Review of Pre-Clinical Systems Using Artificial Microenvironments and Anti-Migratory Drugs to Control Migration of Glioblastoma Cells
Authors: Selvi Hana , Brüning-Richardson Anke , Danovi Davide 
Published: January 2025

Abstract

Background
Glioblastoma multiforme (GBM) is the most prevalent primary brain tumour, with an incidence of 2 per 100,000. The standard clinical treatments do not sufficiently target cell migration and invasion, leading to recurrence after surgical resection and resistance after chemotherapy and radiotherapy. Pre-clinical studies are being conducted to construct artificial substrates that can mimic the tumour microenvironment (TME) to prevent GBM cells from migrating along their primary route through blood vessels and white matter tracts. Alongside, targeted therapies using anti-migratory or ‘migrastatic’ drugs are also being developed. This study aimed to review the therapeutic translational strategies emerging from the study of the GBM microenvironment and anti-migratory drugs.

Methods
A systematic literature search was carried out using search key terms and synonyms. Full-paper screening was performed based on specific inclusion and exclusion criteria.

Results
From the systems interrogated, the ‘Nanofibre’ assay is suitable to simulate white matter tracts, while hydrogel-based invasion assays and GBM cerebral organoid (GLICO) mimic the brain extracellular matrix. Inhibitors with anti-migratory activity found in this study are active involving distinct molecular mechanisms and have been tested on cell migration assays.

Conclusion
Overall, we have analysed therapeutic strategies emerging from an artificial GBM TME approach and from the identification of anti-migratory inhibitors. Both carry potential to improve treatment options to prevent tumour dissemination and spread for GBM.
Wearable technology and daily diaries for studying mental health: lessons learned from pilot studies in Kampala, Uganda
Authors: Nielsen Karen E. , Mobley Kate , Culbreth Rachel , Palmier Jane B. , Matovu Gideon , Nabulya Anna , Swahn Monica H. 
Published: January 2025

Abstract
Wearable technology and daily diaries offer insights into everyday behaviors that can further health research and treatment globally. However, the use of these methodologies outside of high-income settings has been limited. We conducted two pilot studies that enrolled 60 young women in the urban slums of Kampala, Uganda to understand design considerations associated with using wearable technology and daily diaries in this context. Each participant in the pilot studies was asked to wear a wearable activity tracker and complete daily diary questionnaires for 5 days. Based on our experiences, we identified several lessons that may be beneficial to others interested in implementing wearable technology and daily self-reports in their research and interventions, particularly when working in low-resource contexts. We discuss the importance of designing solutions tailored to the available resources, building validation for the most critical measures, investing in data management efforts and providing transparent and culturally accessible information to participants. Examples from our study are provided. These lessons may reduce the barriers and improve data quality for future researchers and practitioners interested in using these data collection methods globally.
Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders
Authors: Ormerod Monica B.E.G. , Ueland Thor , Aas Monica , Hjell Gabriela , Rødevand Linn , Sæther Linn Sofie , Lunding Synve Hoffart , Johansen Ingrid Torp , Mlakar Vid , Andreou Dimitrios , Ueland Torill , Lagerberg Trine V. , Melle Ingrid , Djurovic Srdjan , Andreassen Ole A. , Steen Nils Eiel 
Published: January 2025

Abstract

Objective:
Accelerated ageing indexed by telomere attrition is suggested in schizophrenia spectrum- (SCZ) and bipolar disorders (BD). While inflammation may promote telomere shortening, few studies have investigated the association between telomere length (TL) and markers of immune activation and inflammation in severe mental disorders.

Methods:
Leucocyte TL defined as telomere template/amount of single-copy gene template (T/S ratio), was determined in participants with SCZ (N = 301) or BD (N = 211) and a healthy control group (HC, N = 378). TL was analysed with linear regressions for associations with levels of 12 immune markers linked to SCZ or BD. Adjustments were made for a broad range of potential confounding variables. TL was measured by quantitative polymerase chain reaction (qPCR) and the immune markers were measured by enzyme immunoassays.

Results:
A positive association between levels of soluble tumour necrosis factor receptor 1A (sTNF-R1) and TL in SCZ (β = 0.191, p = 0.012) was observed. Plasma levels of the other immune markers were not significantly associated with TL in the BD, SCZ or HC groups.

Conclusion:
There was limited evidence of association between immune markers and TL in SCZ and BD. The results provide little support for involvement of immune dysregulation, as reflected by current systemic markers, in telomere attrition-related accelerated ageing in severe mental disorders.
Conditions for the supersolvability of $\mathcal{F}_{S}(G)$
Authors: Ru Guotuan , Zhang Shengmin , Shen Zhencai 
Published: January 2025

Abstract
In this article,

$\mathcal{F}_{S}(G)$

denotes the fusion category of G on a Sylow p-subgroup S of G where p denotes a prime. A subgroup K of G has normal complement in G if there is a normal subgroup T of G satisfying that G = KT and

$T \cap K = 1$

. We investigate the supersolvability of

$\mathcal{F}_{S}(G)$

under the assumption that some subgroups of S are normal in G or have normal complement in G.
Crude Knowledge: Petro-Periodicals and Resource Sovereignty
Authors: Khalili Laleh 
Published: January 2025

AbstractThe period of struggle over hydrocarbon sovereignty in the Arab world –the 1950s-1970s– saw a spate of periodicals in Arabic about oil. These included periodicals produced by the public relations departments of Euro-American oil companies, as well as monthlies, weeklies and quarterlies produced by Arab journalists, experts, and former oil revolutionaries in Cairo, Baghdad, Beirut and Kuwait. This essay argues that the trajectory of these latter publications –both their context and content– traces the massive political transformations that saw a shift of power in the region, alongside a radical transformation in the representation of oil from a public good into a private property.
Removal of the mucilage reduces intact seed passage through the digestive system of birds
Authors: Kreitschitz A. , Haase E. , Gorb S.N. 
Published: January 2025

Abstract
Many plants developed unique adaptations such as protective seed coatings or eatable fruits/seeds that aid in seed dispersal by animals. Birds are among the animals that perform endozoochoric diaspore dispersal. In this study, we used mechanically demucilaginated seeds and seeds covered with artificial mucilage with the aim of determining the protective potential of the mucilage envelope against seed digestion during endozoochory by birds. We removed the mucilage from the seeds of Plantago lanceolata, Plantago ovata, Plantago psyllium, and Linum usitatissimum and fed the seeds to pigeons. Using naturally non-mucilaginous seeds of Amaranthus albus, Brassica napus and Nigella sativa, we tested the survival of diaspores covered with artificial mucilage (P. ovata husk) in the digestive systems of pigeons. Among the demucilaginated diaspores (2700 per taxon), no seeds of L. usitatissimum, 1 seed of P. lanceolata, 1 seed of P. ovata and 7 seeds of P. psyllium passed through the bird gut intact. This indicated that after removing the mucilage envelope, few diaspores can pass through the digestive system. Among diaspores with artificial mucilage, 7 seeds (from 8100 total) passed through the bird gut intact. This indicated that the artificial mucilage did not support the survival of the seeds as they passed through the pigeon digestive system. Furthermore, germination experiments revealed a decrease in the germination rate of demucilaginated seeds. They moulded rapidly, and only a few of the seeds germinated. The results of this study demonstrate the significant role of the mucilage in preventing digestion and supporting diaspore germination during endozoochory.
Mapping the concept of fundamentalism: a scoping review
Authors: Kindermann Nora , Peels Rik , Liefbroer Anke I. , Schoonmade Linda 
Published: January 2025

AbstractThis scoping review of conceptualizations of fundamentalism scrutinizes the concept's domain of application, defining characteristics, and liability to bias. We find fundamentalism in four domains of application: Christianity, other Abrahamic religions, non-Abrahamic religions, and non-religious phenomena. The defining characteristics which we identify are organized into five categories: belief, behavior, emotion, goal, and structure. We find that different kinds of fundamentalisms are defined by different characteristics, with violent and oppressive behaviors, and political beliefs and goals being emphasized for non-Christian fundamentalisms. Additionally, we find that the locus of fundamentalism studies is the Global North. Based on these findings, we conclude that the concept is prone to bias. When conceptualizing fundamentalism, three considerations deserve attention: the mutual dependency between the domain of application and the specification of defining characteristics; the question of usefulness of scientific concepts; and the connection between conceptual ambiguity and the risk of bias in the study of fundamentalism.