bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereoelectroencephalography in the setting of a previously implanted responsive neural stimulation device: illustrative case
Authors: Kusyk Dorian M , Blaney Nicholas , Quezada Timothy , Whiting Alexander C 
Published: December 2023

BACKGROUND
Responsive neural stimulation (RNS) is a relatively novel procedure for drug-resistant epilepsy, which involves implantation of a device into the skull and brain. As more devices are implanted, there may be an increasing need to perform intracranial electrocorticography in implant patients with persistent seizures. Given the device location, imaging difficulties with implanted devices, and other technical hurdles, stereoelectroencephalography (SEEG) could be especially challenging. The authors describe the first reported SEEG investigation in a patient with an RNS device, highlighting the technical challenges and clinical data ascertained.

OBSERVATIONS
A 41-year-old male with drug-resistant epilepsy presented several years after a local surgeon had placed an RNS device with two electrodes in the bilateral parieto-occipital lobes. Because of inadequate seizure control, the patient was offered a repeat SEEG investigation to characterize his epilepsy better. Although more technically challenging than a traditional SEEG implantation, the SEEG investigation was successfully performed, which led to a confirmation of bilateral hippocampal seizure onset. The patient underwent repositioning of his RNS leads with a significant decrease in his seizure frequency.

LESSONS
Concurrent implantation of SEEG electrodes in a functioning RNS device can be safely performed and can augment our understanding of a patient’s seizures.
New concept of orthosis treatment for knee osteoarthritis: Clinical and radiological outcomes
Authors: Huizinga Maarten R. , de Vries Astrid J. , Verkerke G.J. , Brouwer Reinoud W. 
Published: December 2023

BACKGROUND: Given the increasing numbers of young patients with knee osteoarthritis there is a need for treatments that can postpone a joint prosthesis (total knee replacement). OBJECTIVE: As an alternative to the effective yet invasive knee joint distraction procedure, a knee orthosis was developed aiming to unload the affected knee and improving synovial fluid flow. The aim of this study was to examine the effectiveness of using a load-reducing orthosis for two months on functioning, pain, and disease progression (e.g. amount of damaged cartilage) in patients with symptomatic osteoarthritis of the knee for at least one year. METHODS: This is an interventional single-center pilot study. Ten patients with symptomatic osteoarthritis of one knee (5 males/5 females; median age 57; age range 42–59) used a custom-made orthosis for 60 days during daily life activities that involved knee loading (e.g. standing, walking, but not during stair climbing). Cycling was not allowed. Clinical outcomes were assessed up to 24 months after intervention at 6 timepoints using patient reported-outcome measures Western Ontario and McMaster Universities Osteoarthritis (WOMAC) range 0–100; Visual Analogue Scale (VAS), range 0–100 for pain. Minimum joint space width (mJSW) was assessed using knee images digital analysis (KIDA) and articular cartilage volume with magnetic resonance imaging (MRI) using custom software at baseline and at 12 and 24 months follow-up. RESULTS: Clinically beneficial effects were found for functioning (WOMAC improvement compared to baseline ranged between 18 points at 3 months follow-up and 31 points at 12 months follow-up, with only the 24-months follow-up (improvement of 27 points) not reaching statistical significance (p< 0.05)) and for pain (VAS improvement compared to baseline at follow-up time points ranged between 41–56 points; all p< 0.05). No improvements in mJSW- or MRI-derived parameters were found. CONCLUSION: This study demonstrates that use of a custom-made knee-unloading orthosis for 60 days can result in improved functional ability and decrease in pain in relatively young patients with knee osteoarthritis. No effect on disease progression could be evidenced.
Substantiation for a new non-contact measurement technique in electrical resistance surveys
Authors: Karinskiy A. D. , Ivanov A. A. , Zudenkov I. A. , Matyushenko A. A. , Novikov Р. V. 
Published: December 2023

Background. Methods for electrical resistance surveys include those of electrical sounding and electrical profiling with various arrays. Measurements were originally carried out at direct current, although low-frequency alternating current was used later. In the case of direct current, the sole sources of the primary electric field in these methods comprise the charges of the A, B current electrodes, with the measured value being the electric field voltage E equal to the potential difference ΔUMN in the MN line with the measuring electrodes M, N. According to the measurement results, the apparent electrical resistivity is determined, which is convenient for interpreting the measurement results ρк. However, in some cases, e.g., when conducting measurements in permafrost areas, it can be difficult to ensure reliable grounding of the electrodes. Therefore, half a century ago, research was initiated to substantiate the possibility of contactless measurements in the method of electrical profiling with the alternating current I in the AB line. Until recently, the technique of non-contact measurements and interpretation of the results obtained has been based on approximate approaches, rather than on a strict solution of the forward problem of electrodynamics.Aim. Objective substantiation of the non-contact measurement technique based on the solution of a forward electrodynamics problem.Materials and methods. The data obtained by mathematical simulation were analyzed.Results. The results of calculations for a model corresponding to the possible conditions for contactless measurements in electrical exploration by the resistance method are presented. A case is considered when a generator line AB of a harmonically varying current I is located in the air, at a height h above a homogeneous conducting half-space with a specific electrical ρ2.Conclusion. In comparison with the method currently used for non-contact measurements, it seems more effective to determine the apparent electrical resistivity from the reactive component of the electric field voltage E in the measuring line MN that varies in phase with the current I in the generator line AB.
Forecast of oil and gas reservoirs of the Sea of Okhotsk based on interpretation processing of seismic material
Authors: Shatyrov А. К. 
Published: December 2023

Background.This article analyses the results of geological and geophysical studies conducted in the Okhotsk Sea area with the purpose of developing methods for processing seismic information in combination with other data to solve the problems of forecasting hydrocarbon deposits.Aim. Solving problems of forecasting hydrocarbon deposits through the development of a structural and technological scheme for prospecting and evaluation of a geological and geophysical model to identify images of oil and gas deposits.Materials and methods. The research methodology included selection of the location of points for simulating “vertical wells” in order to analyze the geodynamics of the medium; multiplex parametric transformations of wave fields taking into account diagnostic significant attributes and building a multiparametric cluster; selection of oil and gas deposits; formation of images of oil and gas deposits; local forecast of improved reservoir properties and saturation; refinement of the geometry of target surfaces with forecast data in actual points (vertical wells); forecast of the area of target surfaces; spatial mapping of the largest hydrocarbon deposits.Results. Forecasting of oil and gas prospects in the Okhotsk Sea in areas where there is no deep drilling can be carried out using the following technologies: detailing the structural and tectonic structure of hydrocarbon traps; multi-feature prediction of hydrocarbon deposits; decomposition of the dispersion of the wave field; low-frequency resonance of seismic emission geodynamic noise; selection of oil and gas-containing objects.
ANALISIS PENDAPATAN USAHA PENGGEMUKAN SAPI POTONG KTT PADUSAN KABUPATEN CIREBON
Authors: Arisandi Bayu , Aruman Asep 
Published: December 2023

Tujuan penelitian ini untuk mengetahui berapa pendapatan peternak sapi potong yang ada di Kelompok Tani Ternak Sapi Padusan. Materi yang menjadi obyek pengamatan dalam kegiatan Praktik Kerka Lapangan adalah peternak sapi yang menjadi anggota Kelompok Tani Ternak Sapi Padusan. Jumlah peternak kelompok sapi padusan berjumlah 16 orang. Pengumpulan Data dilakukan dengan Observasi dan wawancara. Observasi yaitu melakukan pengamatan langsung terhadap usaha peternakan sapi potong yang dilakukan oleh anggota Kelompok Tani Ternak Sapi Padusan. Sedagkan wawancara yaitu pengambilan data dengan memberikan pertanyaan kepada peternak serta berkomunkasi langsung untuk memperoleh data-data yang diperlukan. Berdasarkan hasil dan pembahasan maka dapat ditarik kesimpulan, bahwa keuntungan Kelompok Tani Ternak Sapi Padusan adalah Rp. 446,429,000. Keuntungan diperoleh dari hasil pengurangan anatara Penerimaan (Penjualan Sapi) dengan total biaya produksi (Biaya Tetap dan Biaya Variabel) selama periode pemeliharaan. Perbedaan penerimaan yang diperoleh oleh masing- masing peternak berbeda-beda disebabkan karena perbedaan jenis sapi, jumlah ternak sapi potong yang di miliki dan jenis pakan yang digunakan. Belum adanya pengelolan limbah di Kelompok Tani Ternak Sapi Padusan merupakan salah satu faktor yang menyebabkan belum maksimalnya pendapatan Kelompok Tani Ternak Sapi Padusan. Oleh karena itu Kelompok Tani Ternak Sapi Padusan harus melakukan pengelolaan limbah peternakan antara lain dengan pengolahan pupuk padat (kompos), pupuk cair (urine) dan biogas, dengan adanya pengolahan tersebut maka pencemaran lingkungan dapat diatasi dan dapat menghasilkan penerimaan dari penjualan pupuk organik tersebut.
Kata Kunci: Analisis Pendapat, KTT, Sapi Potong.
Four poems, Transcendental Friend
Authors: Nguyen Hoa 
Published: December 2023

<p>Four poems: </p>
<p><strong>[Unorthodox & impractical one not led]</strong></p>
<p><strong>[Flying colors land divide a place You]</strong></p>
<p><strong>[Exhaustion break through challenges]</strong></p>
<p><strong>[Grow baby grow a brain with curly]</strong></p>
Pola Kepemimpinan Kepala Madrasah dan Relevansi Terhadap Mutu Pendidikan di Madrasah Aliyah Al-Islam Kemuja
Authors: Rohati Siti 
Published: December 2023

Penelitian ini didasarkan pada pertimbangan bahwa pola kepemimpinan kepala madrasah memiliki andil terbesar dalam proses peningkatan mutu pendidikan. Kepala madarasah merupakan pemimpin tertinggi serta yang paling bertanggung jawab terhadap maju atau mundurnya kualitas pendidikan. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pola kepemimpinan kepala madrasah serta relevansi terhadap mutu pendidikan di Madrasah Aliyah Al Islam Kemuja. Penelitian ini merupakan penelitian lapangan yang bersifat kualitatif deskriptif. Pengumpulan data diperoleh melalui wawancara, observasi, dokumentasi serta analisis data. Hasil penelitian menunjukkan bahwa, pertama pola kepemimpinan kepala Madrasah Aliyah Al Islam Kemuja merupakan pola kepemimpinan yang demokratis, berfokus pada hubungan kerja sama internal maupun eksternal, serta termasuk ke dalam kepemimpinan yang berpola pada hasil yang ingin dicapai. Kedua, relevansi pola kepemimpinan kepala madrasah terhadap mutu pendidikan di Madrasah Aliyah Al Islam Kemuja sangat mendukung kualitas mutu pendidikan di Madrasah Aliyah Al Islam Kemuja. Dalam kepemimpinannya kepala madrasah melakukan perencanaan, pengorganisasian, pelaksanaan, serta controlling dengan baik, sehingga hal-hal tersebut mendukung perkembangan mutu pendidikan di Madrasah Aliyah Al Islam Kemuja. Kesimpulan dari penelitian ini adalah kepemimpinan kepala madrasah yang demokratis, berfokus pada hubungan kerja, dan berpola pada hasil yang ingin dicapai mendukung peningkatan kualitas mutu pendidikan di Madrasah Aliyah Al Islam Kemuja
Population-based incidence of all-cause anaphylaxis and its development over time: a systematic review and meta-analysis
Authors: Pühringer Vanessa , Jilma Bernd , Herkner Harald 
Published: December 2023

IntroductionIt is extremely difficult to compare studies investigating the frequency of anaphylaxis making it challenging to satisfactorily assess the worldwide incidence rate. Using a systematic review and meta-analysis, this publication aims to determine the current incidence of all-cause anaphylaxis worldwide. Additionally, we investigated whether the incidence of anaphylaxis has changed over time and which factors influence the rates determined by individual studies.MethodsA literature search was performed in four databases. All articles that reported relevant information on population-based incidence rates of all-cause anaphylaxis were included. The protocol was published on INPLASY, the International Platform of Registered Systematic Review and Meta-analysis Protocols.ResultsThe database query and screening process resulted in 46 eligible articles on anaphylaxis. The current incidence worldwide was found to be approximately 46 cases per 100,000 population per year (95% CI 21–103). Evaluating confounding factors showed that studies using allergy clinics and hospitalizations as data source result in comparably low rates. Moreover, children are less prone to develop anaphylaxis compared to the general population. Using a random effects Poisson model we calculated a yearly increase of anaphylaxis incidence by 7.4% (95% CI 7.3–7.6, p &lt; 0.05).DiscussionThis seems to be the first approach to analyze every reported all-cause anaphylaxis incidence rate until 2017 for an at most accurate determination of its epidemiology. Based on these results, future research could investigate the underlying causes for the rising incidence in order find ways to decrease the condition’s frequency.Systematic Review Registrationinplasy.com, identifier [INPLASY202330047]
Au nanorod assembly for sensitive SERS detection of airway inflammatory factors in sputum
Authors: Yang An-qi , Zheng Wentong , Chen Xiaoyang , Wang Jiayin , Zhou Shuang , Gao Hongzhi 
Published: December 2023

In this paper, we demonstrate a surface-enhanced Raman spectroscopy (SERS) biosensor based on the self-assembly of gold nanorods (AuNRs) for the specific detection of airway inflammatory factors in diluted sputum. The AuNR surface was modified with an antibody that was able to specifically recognize an airway inflammatory factor, interleukin-5 (IL-5), so that a end-to-end self-assembly system could be obtained, resulting in an order of magnitude amplification of the Raman signal and greatly improved sensitivity. Meanwhile, the outer layer of the biosensor was coated with silicon dioxide, which improved the stability of the system and facilitated its future applications. When the detected concentration was in the range of 0.1–50 pg/mL, the SERS signal generated by the sensor showed a good linear relationship with the IL-5 concentration. Moreover, it had satisfactory performance in diluted sputum and clinical subjects with asthma, which could achieve sensitive detection of the airway inflammatory factor IL-5. Overall, the developed biosensor based on the SERS effect exhibited the advantages of rapid and sensitive detecting performance, which is suitable for monitoring airway inflammatory factors in sputum.
Preparation and reverse recycling logistics of a new type of nano-filled antibacterial layer packaging film for dairy products
Authors: Li Quan , Zhou Xiaorong , Wu Hong 
Published: December 2023

Introduction: Dairy products are loved by people because of their high nutritional value, but they have also become the most ideal breeding places for microorganisms. Some dairy packaging has the problem of lax sealing, resulting in products susceptible to contamination and deterioration. The harmful microorganisms and bacteria contained in them will pose a serious threat to people’s health. Therefore, a good antibacterial protection is very important for dairy products. The purpose of this paper is to study the preparation and reverse recycling logistics of a new type of nano-filled antibacterial layer packaging film for dairy products.Methods: A new type of nano-filled antibacterial layer packaging film is prepared by extrusion casting method, and its mechanical properties and antibacterial properties are analyzed.Results: The experimental results in this article show that the prepared new nano-filled antibacterial layer packaging film has lower light transmittance and water vapor transmission rate, and has obvious antibacterial properties against Staphylococcus aureus and Escherichia coli, and has good barrier properties.Discussion: The antibacterial rate of the bacteria in the petri dish is as high as 99.97% after being placed for 120 days, and the antibacterial performance can be enhanced by the ratio of glycerol and starch content, and the new nano-filled antibacterial film prepared is degradable Sex, can be better recycled.
Type 2 diabetes mellitus and the risk of male infertility: a Mendelian randomization study
Authors: Zhu Xiao-Bin , Niu Zhi-Hong , Fan Wei-Min , Sheng Chang-Sheng , Chen Qian 
Published: December 2023

ObjectiveTo assess the causal effect of type 2 diabetes mellitus (T2DM) on male infertility (MI) and erectile dysfunction (ED) by Mendelian randomization (MR) analysis.MethodsData for T2DM, MI, and ED were obtained from genome-wide association studies (GWAS) involving 298, 957, 73, 479, and 223, 805 Europeans, respectively. We performed univariate MR analysis using MR Egger, Weighted median (WM) and Inverse variance weighted (IVW) methods to assess causal effects among the three. Through the Genotype Tissue Expression (GTEx) database, single-nucleotide polymorphisms (SNPs) that affect the expression levels of T2DM-related genes were located using expression quantitative trait loci (eQTL).ResultsMR analysis showed a significant causal relationship between T2DM and ED (WM, OR: 1.180, 95%CI: 1.010-1.378, P = 0.037; IVW, OR: 1.190, 95%CI: 1.084-1.300, P &lt; 0.001). There is also a significant causal relationship between T2DM and MI (MR Egger, OR: 0.549, 95%CI: 0.317-0.952, P = 0.037; WM, OR: 0.593, 95%CI: 0.400, P = 0.010; IVW, OR: 0.767, 95%CI: 0.600-0.980, P = 0.034). ED may not cause MI (P &gt; 0.05). We also found that rs6585827 corresponding to the PLEKHA1 gene associated with T2DM is an eQTL variant affecting the expression of this gene.ConclusionT2DM has a direct causal effect on ED and MI. The level of PLEKHA1 expression suppressed by rs6585827 is potentially associated with a lower risk of T2DM.
Causal effects of non-alcoholic fatty liver disease on osteoporosis: a Mendelian randomization study
Authors: Zhou Yue , Ni Yunzhi , Wang Zhihong , Prud’homme Gerald J. , Wang Qinghua 
Published: December 2023

BackgroundOsteoporosis (OP) is a systemic skeletal disease characterized by compromised bone strength leading to an increased risk of fracture. There is an ongoing debate on whether non-alcoholic fatty liver disease (NAFLD) is an active contributor or an innocent bystander in the pathogenesis of OP. The aim of this study was to assess the causal association between NAFLD and OP.MethodsWe performed two‐sample Mendelian randomization (MR) analyses to investigate the causal association between genetically predicted NAFLD [i.e., imaging‐based liver fat content (LFC), chronically elevated serum alanine aminotransferase (cALT) and biopsy-confirmed NAFLD] and risk of OP. The inverse variant weighted method was performed as main analysis to obtain the causal estimates.ResultsImaging-based LFC and biopsy-confirmed NAFLD demonstrated a suggestive causal association with OP ([odds ratio (OR): 1.003, 95% CI: 1.001-1.004, P &lt; 0.001; OR: 1.001, 95% CI: 1.000-1.002, P = 0.031]). The association between cALT and OP showed a similar direction, but was not statistically significant (OR: 1.001, 95% CI: 1.000-1.002, P = 0.079). Repeated analyses after exclusion of genes associated with confounding factors showed consistent results. Sensitivity analysis indicated low heterogeneity, high reliability and low pleiotropy of the causal estimates.ConclusionThe two‐sample MR analyses suggest a causal association between genetically predicted NAFLD and OP.
Comprehensive analysis of the prognostic implication and immune infiltration of CISD2 in diffuse large B-cell lymphoma
Authors: Zhang ChaoFeng , Lin Qi , Li ChunTuan , Qiu Yang , Chen JingYu , Zhu XiongPeng 
Published: December 2023

BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common B-cell lymphoma in adults. CDGSH iron sulfur domain 2 (CISD2) is an iron–sulfur protein and plays a critical role of cell proliferation. The aberrant expression of CISD2 is associated with the progression of multiple cancers. However, its role in DLBCL remains unclear.MethodsThe differential expression of CISD2 was identified via public databases, and quantitative real-time PCR (qRT-PCR) and western blot were used to identifed the expression of CISD2. We estimated the impact of CISD2 on clinical prognosis using the Kaplan-Meier plotter. Meanwhile, the drug sensitivity of CISD2 was assessed using CellMiner database. The 100 CISD2-related genes from STRING obtained and analyzed using the LASSO Cox regression. A CISD2 related signature for risk model (CISD2Risk) was established. The PPI network of CISD2Risk was performed, and functional enrichment was conducted through the DAVID database. The impacts of CISD2Risk on clinical features were analyzed. ESTIMATE, CIBERSORT, and MCP-counter algorithm were used to identify CISD2Risk associated with immune infiltration. Subsequently, Univariate and multivariate Cox regression analysis were applied, and a prognostic nomogram, accompanied by a calibration curve, was constructed to predict 1-, 3-, and 5-years survival probabilities.ResultsCISD2 was upregulated in DLBCL patients comparing with normal controls via public datasets, similarly, CISD2 was highly expressed in DLBCL cell lines. Overexpression of CISD2 was associated with poor prognosis in DLBCL patients based on the GSE31312, the GSE32918, and GSE93984 datasets (P&lt;0.05). Nine drugs was considered as a potential therapeutic agents for CISD2. By using the LASSO cox regression, twenty seven genes were identified to construct CISD2Risk, and biological functions of these genes might be involved in apoptosis and P53 signaling pathway. The high CISD2Risk value had a worse prognosis and therapeutic effect (P&lt;0.05). The higher stromal score, immune score, and ESTIMATE score were associated with lowe CISD2Risk value, CISD2Risk was negatively correlated with several immune infiltrating cells (macrophages M0 and M1, CD8 T cells, CD4 naïve T cells, NK cell, etc) that might be correlated with better prognosis. Additionally, The high CISD2Risk was identified as an independent prognostic factor for DLBCL patients using both univariate and multivariate Cox regression. The nomogram produced accurate predictions and the calibration curves were in good agreement.ConclusionOur study demonstrates that high expression of CISD2 in DLBCL patients is associated with poor prognosis. We have successfully constructed and validated a good prognostic prediction and efficacy monitoring for CISD2Risk that included 27 genes. Meanwhile, CISD2Risk may be a promising evaluator for immune infiltration and serve as a reference for clinical decision-making in DLBCL patients.