bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binucleated lymphocytes on peripheral blood smear associated with poor prognosis in chronic lymphocytic leukemia
Authors: Wang Yan , Zhong Miao , Chen Lvwen , Liu Hailing , Wang Hui , Zhang Jianfu , Wu Yujie , Qiao Chun , Chou Hairong , Yang Hui , Li Jianyong , Fan Lei , Wang Rong 
Published: December 2023

Abstract
Background: Chronic lymphocytic leukemia (CLL) is a common lymphoproliferative disease involving B cells, and small lymphocytic lymphoma (SLL) is regarded as the solid tumor counterpart of CLL. Both of them share the same morphology, which appear as small, mature-appearing lymphocytes with a scanty amount of cytoplasm and a clumped nuclear chromatin. While some cases have reported the presence of binucleated lymphocytes on peripheral blood smears of a small part of CLL patients. However, the prognostic value of this atypical morphologyin CLL patients has not been well acknowledged.
Method: We retrospectively reviewed 325 newly diagnosed CLL/SLL patients. Blood smears were performed by Wright-Giemsa stain and used for morphometric assessment. Cytogenetic aberrations were assessed by chromosome banding analysis. Genetic characterization was analyzed by direct Sanger sequencingor FISH.
Result: Binucleated lymphocytes observed on peripheral blood smear presented with two similar size and relatively symmetrical nuclei, but varied in size and forms. 308 patients (94.8%) were defined as binucleated lymphocytes negative (BLN) and 17 patients (5.2%) as binucleated lymphocytes positive (BLP). In particular, multinucleated lymphocytes were found in 2 cases. Binucleated lymphocytes were highly correlated with prolymphocytes and dividing lymphocytes. BLP had a higher proportion of complex karyotypes, unmutated IGHV, TP53 mutation or depletion, and a lower proportion of 13q deletion. In addition, there was a significant association between the presence of binucleated lymphocytes and overall survival. In cases withmutated IGHV or without TP53 mutation or deletion, overall survival of BLP was significantly shorter.
Conclusion: The observation of binucleated lymphocytes should be considered as a negative prognostic parameter for CLL, especially in lower genetic-risk CLL population. The morphological examination of blood smear in CLL is still worthy, for its advantages of saving of time, laboratory technique, and simplicity and convenience.
The Temporal Relationship between Social Adaptation and Depression: The Moderating Role of Social Isolation
Authors: Li Xiaowen , He Yuanqing , Zhang Jun , Chen Shuhu 
Published: December 2023

Abstract
Background Social Adaptation(SA) and Depression significantly challenge the elderly's psychological health. The complex interplay between these conditions, particularly in the context of varying different levels of social isolation(SI), is not well-understood.
Methods In this study, we utilized the China Longitudinal Aging Social Survey (CLASS) database to classify participants into groups of low and high SI, based on their scores. Network analysis was used to examine the relationships between symptoms of SA and Depression at two distinct time points across different levels of SI. We then applied Cross-Lagged Panel Network (CLPN) analysis to assess the longitudinal causal relationships between these symptoms, focusing on the moderating role of SI.
Results Our findings reveal that, compared to the Low-SI group, the High-SI group exhibits more intricate relationships between social adaptation and depression, indicating a significant modulatory effect of SI on these correlations. Key symptoms identified as bridge items in the networks of SA and Depression include "Not accepting new ideas," "Do something more," and "Sad." In the cross-lagged analysis, "Loss of appetite" showed the greatest impact in the Low-SI group, while "Good mood" was predominant in the High-SI group.
Conclusions This research provides valuable insights into the underlying mechanisms of interaction between SA and Depression, underscoring SI pivotal role in this dynamic.
Reexplain the Liquid Junction Potential according to the force equilibrium of ions
Authors: Wang Xuefei , Wang Yang , Yang Junyi , Wang Kaiyang , Shi Shuaian , Liu Yun 
Published: December 2023

Abstract
Liquid junction potential (LJP) is an important term in electrochemical system. As known, LJP is caused by the different diffusion ration of cations and anions. We found that in most textbooks and literatures, the value of LJP was expressed as a function of ions transfer numbers, rather than diffusion coefficients. This makes students feel confused. In the present work, based on the force equilibrium of ions at the liquid-liquid interface, an equation including the diffusion coefficient is given to highlight the physical cause of LJP.
HMGN1 is a potential chemotherapeutic target for lung adenocarcinoma.
Authors: Wu Xianli , Cai Geqi , Feng Jing , Lin Wenchu 
Published: December 2023

Abstract

The high mobility group nucleosome binding (HMGN) family, constitutes a large family of non-histone protein family known to bind the acidic patch of the nucleosomes with various key cellular functions. Several studies have highlighted the pivotal roles of HMGNs in the pathogenic process of various cancer types. However, the roles of HMGN family in lung adenocarcinoma (LUAD) have not been fully elucidated. Herein, integrative analyses of multiple-omics data revealed that HMGNs frequently exhibit dysregulation in LUAD. Subsequent analysis of the clinical relevance of HMGN1 demonstrated its association with poor prognosis in LUAD and its potential as a diagnostic marker to differentiate LUAD from heathy controls. Additionally, functional enrichment analysis suggested that HMGN1 was mainly involved in DNA repair. To corroborate these findings, cellular experiments were conducted, confirming HMGN1’s crucial involvement in homologous recombination repair and its potential to enhance the sensitivity of LUAD cells to standard chemotherapeutic drugs. This study proposes HMGN1 as a novel prognostic biomarker and a promising target for chemotherapy in lung adenocarcinoma.
Effect of Cervical Paraesophageal Lymph Node Metastasis Versus Supraclavicular Lymph Node Metastasis on the Overall Survival of Patients with Thoracic Esophageal Squamous Cell Carcinoma: A Long-term Survival Analysis
Authors: Li Kexun , Li Changding , Lu Simiao , Wang Chenghao , Han Yongtao , Leng Xuefeng , Peng Lin 
Published: December 2023

Abstract
Background: Esophageal cancer (EC) is a major global health burden, with a particularly high incidence in East Asia. Supraclavicular lymph node metastasis(LNM) has notable effects on the overall survival (OS) of patients with EC after esophagectomy. We aimed to investigate the effect of LNM in cervical paraesophageal lymph nodes (station 101) and supraclavicular lymph nodes (station 104) on the OS of patients who underwent esophagectomy for esophageal squamous cell carcinoma (ESCC).
Methods: Data were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management (SCH-ECCM) database. We retrospectively analyzed the patients with EC who underwent esophagectomy from January 2010 to December 2017. These patients were allocated into two groups based on the presence of LNM in the cervical paraesophageal or supraclavicular regions. Clinical outcomes and survival data were compared using the TNM staging system of the 8th edition of American Joint Committee on Cancer (AJCC).
Results: After a median follow-up of 62.1 months, 122 patients with LNM in the supraclavicular region were included in the study. Among these patients, 53 showed cervical paraesophageal LNM and an OS of 19.9 months (95% CI: 16.3-23.5). In contrast, 69 patients showed supraclavicular LNM with an OS of 34.9 months (95% CI 25.7-44.1). The OS rates at 1, 3, and 5 years were 77%, 29%, and 21%, respectively, for patients with cervical paraesophageal LNM. Moreover, patients with supraclavicular LNM demonstrated OS rates of 88%, 48%, and 34%, respectively (HR: 0.634, 95% CI: 0.402-1.000, P = 0.042).
Conclusions: Patients with ESCC with cervical paraesophageal LNM had significantly worse OS than those with supraclavicular LNM. This study underscores the importance of accurately identifying and managing ESCC with cervical paraesophageal LNM, as it may require more tailored and aggressive treatment strategies to prolong patient survival.
Selection of families obtained from caryopsis in a polyploid species (Saccharum spp.) using multicategory model
Authors: Borsuk Luiz Gustavo da Mata , Montini Leticia Martins , Neto Hugo Zeni , Machado Maria de Fátima pires da Silva , Mangolin Claudete Aparecida , Cristina Joseli Silva , Santos Renato Frederico 
Published: December 2023

Abstract
Genetic diversity analysis is essential for sugarcane (Saccharum spp.) breeding programs. Crossbreeding based on genetic distances between the parental plants is one of the tools to increase genetic variability and enhance plant selection. The present study aimed to evaluate diversity within and between twelve families (A, B, C, D, E, F, G, H, I, J, K, and L) of sugarcane, derived from caryopses, using primers for sixteen microsatellite loci, five SSR (Simple Sequence Repeats) loci, and eleven EST-SSR (Expressed Sequence Tag-SSR) loci. Similarity calculations used the Bruvo`s distances among individuals and RST distances among families. The analysis of molecular variance (AMOVA) indicated that the majority of genetic variability is within families (72%), with only 28% found between families. The highest genetic similarity was observed between families E and I, while the lowest genetic similarity was between families K and D. Despite the high genetic similarity observed among the twelve sugarcane families in this study, the percentage of genetic variation within families in the 16 SSR and EST-SSR loci was high (72%), showing promise for exploitation in breeding programs to expand or restrict genetic variability in the selection of desirable morpho-agronomic traits in the crop. Furthermore, the study highlights the importance of using appropriate distances for diversity studies with co-dominant markers such as microsatellites in polyploid species.
A Note on Two of Ramanujan's Mock Theta Functions
Authors: McIntosh Richard John 
Published: December 2023

Abstract
In the “Lost” Notebook Ramanujan defined two mock theta functions (which we denote by φR and ξR) and gave relations connecting them to some of the sixth-order mock theta functions. It turns out that these mock theta functions are related to each other by modular transformation. Their transformation formulas are similar to the transformation formulas for the second-order mock theta functions, and involve the same Mordell integrals. We prove several relations involving φR and ξR, and some relations connecting them to some of the second-order mock theta functions. Some alternate formulas for the second-order mock theta function µ are given.
2010 Mathematics Subject Classification: Primary – 11F27, 11F37, 11F50
Gradient Deformation Criterion of Brittle Fracture. Analytical Grounds and Experimental Confirmation
Authors: Kuliev Valeh Dzhafarovich , Morozov Evgeny Mikhailovich , Kurbanmagomedov Arslan Kurbanmagomedovich 
Published: December 2023

Abstract
In the article [1], we propose a new fracture criterion based on the assumption that brittle fracture occurs when the deformation gradient modulus reaches a limit value. We consider in more detail the fact that the modulus of the temperature gradient, and, consequently, that of the deformation, becomes significant in a thin boundary layer where a quick temperature change occurs. We also present the solution of a new thermoelastic problem of a quick temperature change in a circular area. As it turned out, in the case of a curved boundary of the cooled area E2, where E2 is the Euclidean plane, the fracture criterion becomes complicated and gets a form of a limit value of the gradient modulus of the main deformations sum or just of the main stresses sum. Destruction is determined by the criterion the time of which setting in is less. It is also shown in the aticle that in the case of a heated circular area in E2 the criterion for brittle fracture of a continuum medium is the limit value of the gradient modulus of the main deformations sum. The results of the preliminary experiment with organic glass samples during a quick temperature change in the area with a rectilinear boundary are presented. During the experiment, there appeared a crack along the boundary of the temperature leap, although the stresses across this boundary are equal to zero, but there is a significant deformation gradient.
Establishment of a synchronized tyrosinase transport system revealed a role of Tyrp1 in efficient melanogenesis by promoting tyrosinase targeting to melanosomes
Authors: Nakamura Hikari , Fukuda Mitsunori 
Published: December 2023

Abstract
Tyrosinase (Tyr) is a key enzyme in the process of melanin synthesis that occurs exclusively within specialized organelles called melanosomes in melanocytes. Tyr is synthesized and post-translationally modified independently of the formation of melanosome precursors and then transported to immature melanosomes by a series of membrane trafficking events that includes endoplasmic reticulum (ER)-to-Golgi transport, post-Golgi trafficking, and endosomal transport. Although several important regulators of Tyr transport have been identified, their precise role in each Tyr transport event is not fully understood, because Tyr is present in several melanocyte organelles under steady-state conditions, thereby precluding the possibility of determining where Tyr is being transported at any given moment. In this study, we established a novel synchronized Tyr transport system in Tyr-knockout B16-F1 cells by using Tyr tagged with an artificial oligomerization domain FM4 (named Tyr-EGFP-FM4). Tyr-EGFP-FM4 was initially trapped at the ER under oligomerized conditions, but at 30 min after chemical dissociation into monomers, it was transported to the Golgi and at 9 h reached immature melanosomes. Melanin was then detected at 12 h after the ER exit of Tyr-EGFP-FM4. By using this synchronized Tyr transport system, we were able to demonstrate that Tyr-related protein 1 (Tyrp1), another melanogenic enzyme, is a positive regulator of efficient Tyr targeting to immature melanosomes. Thus, the synchronized Tyr transport system should serve as a useful tool for analyzing the molecular mechanism of each Tyr transport event in melanocytes as well as in the search for new drugs or cosmetics that artificially regulate Tyr transport.
The CCL2-CCR2 axis contributes to acquired osimertinib resistance in lung cancer by upregulating Zeb1 expression
Authors: Chang Tzu-Hua , Tsai Meng-Feng , Wu Shang-Gin , Liu Yi-Nan , Wu Huey-Dong , Tsai Tzu-Hsiu , Lu Pei-Hua , Jheng Han-Nian , Hsu Chia-Lang , Yeh Pu Sheng , Shih Jin-Yuan 
Published: December 2023

Abstract

Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), effectively treats non-small-cell lung cancer patients with EGFR activation mutations or those with acquired T790M resistance mutation following EGFR-TKIs therapy. However, the development of drug resistance remains a significant clinical challenge. Therefore, we aimed to investigate novel cytokine signaling pathways contributing to osimertinib resistance in lung cancer. Our findings revealed that the CCL2-CCR2 signaling pathway is pivotal in osimertinib resistance development. We observed elevated CCL2 expression in EGFR TKIs-resistant lung cancer cells compared to treatment-naive EGFR mutant cells. Furthermore, ectopic expression of CCL2 in osimertinib-sensitive lung cancer cells conferred resistance to osimertinib in vitro and in vivo. CCL2 knockdown improved osimertinib-induced apoptosis in lung cancer cells. Osimertinib-resistant cells exhibited epithelial-mesenchymal transition phenotypes. We demonstrated that CCL2 primarily confers osimertinib resistance through CCR2, STAT3, and ERK, upregulating Zeb1 expression. Finally, combining a STAT3 inhibitor with osimertinib overcoming resistance in vivo. In conclusion, CCL2 significantly contributes to acquired osimertinib resistance in lung cancer. Targeting the CCL2-CCR2-STAT3/ERK-Zeb1 signaling pathway holds therapeutic potential for overcoming osimertinib resistance and improving treatment outcomes.
Analytical Determination of Nusselt Numbers for Convective Heat Transfer Coefficients in Macroporous Absorbers of High-Temperature Solar Receivers
Authors: Cheilytko Andrii , Schwarzbözl Peter , Broeske Robin Tim 
Published: December 2023

Abstract
The article presents a new analytical equation for calculating the Nu number in a macroporous structure of channel absorbers for high- temperature solar receivers. This equation is characterized by including the processes of heat and mass transfer in the boundary layers when the flow passes through a macroporous absorber channel of complex shape. The necessity of considering the length of the thermodynamic boundary layer in a macroporous medium of channel type, when calculating the heat transfer coefficient according to the Nusselt equation, is shown. Including the proposed indicators of porosity and flow characteristics in a macroporous channel significantly increases the accuracy of calculations of the heat transfer coefficient for macroporous channel media. The lack of consideration of certain of the proposed values in the Nusselt number for macroporous media explains the discrepancies in the existing calculation relationships and experiments. The empirical coefficients for the Nusselt number are proposed and obtained by the statistical method. The new semi-empirical equation obtained for macroporous channel media is applied to macroporous absorbers of solar receivers. The obtained results will help to predict the characteristics of future macroporous absorbers much more accurately than before to make them more efficient. The obtained equation for calculating the Nusselt number for channel-like macroporous absorbers has been successfully tested for the receiver of concentrated solar power plants with different geometric structure of the absorber.
Vid-dsa and Glorot-hs-cnn-based Secure Request Scheduling in Urban Vanet
Authors: Velayudhan Nitha C , Madanan Mukesh , Pradeep Arun 
Published: December 2023

Abstract
Advancement in technology, which has solved greater traffic problems utilizing Vehicular Adhoc NETwork (VANET), has made vehicles communicate with each other by means of Road Side Units (RSU). But, in urban areas, reducing traffic is quite difficult owing to the random movement of vehicles. Thus, this paper proposes a secured routing framework utilizing Vehicle ID-based Digital Signature Algorithm(VID-DSA) and Glorot-Hyperbolic Sine-CNN (Glorot-HS-CNN) techniques. Primarily, the number of vehicles on the road is initialized and registered in the Trusted Authority (TA). During registration, the certificate is issued utilizing VID-DSA. After that, certificate verification takes place when the new user vehicle sends a request to the RSU. Then, for efficient route generation, attributes are extracted from the verified user utilizing the Vectorized-Street RAndom Waypoint (V-STRAW) traffic model. Afterward, the optimal path is selected for the corresponding user vehicles' requests utilizing the Constriction Factor-Battle Royale Optimization (CF-BRO) algorithm for avoiding data collision along with uneven delay. Now, the optimal path is transferred to the user vehicle. At last, grounded on the optimal path, the RSU schedules the requests centered on the network entry time. Lastly, the proposed technique’s performance is validated by analogizing it with the prevailing approaches. The outcomes displayed that when contrasted with other systems, the proposed technique achieves enhancement in performance.
Hybrid Optimization Algorithm of OAFS and ICS with CNN-based Energy Level Prediction for Wireless Sensor Networks
Authors: Jagadeesh S. , Mahesh C. , Kumar A. Narendra , Alleema N. Noor 
Published: December 2023

Abstract
In order to maximize network duration and attain power efficiency in wireless sensor networks, clustering, and routing are two notable optimization problems (WSNs). The clustering and routing procedure is an example of an NP-hard issue that can be solved using a metaheuristic optimization method. Clustering is a suitable procedure that is frequently used to improve network power efficiency. Concurrently, difficult cluster head (CH) election and potential Base Station (BS) pathways increase energy consumption and cut down the lifetime of the WSN. This paper proposes an Improved Cuckoo Search (ICS) routing method along with Oppositional Artificial Fish Swarm (OAFS) based clustering as a solution to this issue. The OAFS-ICS approach that has been suggested makes good use of OAFS-based clustering to choose the CHs. In this case, a refined Deep Convolutional Neural Network (DCNN) is worn to make predictions about the energy level. The CH parameters like distance to BS (DBS), residual energy, node degree (ND) and node centrality are used to calculate a fitness function (FF). Several scenarios are utilised to calculate the performance of the current technique depending on the number of nodes. Numerous simulations were conducted in order to confirm the supplied model's superiority. The simulation results demonstrated that the OAFS-ICS technique beat the comparison methods in terms of a variety of criteria.
A model on transitions between steady states of sub-Keplerian accretion discs
Authors: Ajay Arunima , Rajesh S R , Singh Nishant K 
Published: December 2023

Abstract
We present here a simple hydrodynamic model based on a sequence of steady states of the inner sub-Keplerian accretion disc to model its spectral states. Correlations between different hydrodynamic steady states are studied with a goal to understand the origin of, e.g., the aperiodic variabilities. The plausible source of corona/outflow close to the central compact object is shown to be a consequence of steady state transition in the underlying accretion flow. We envisage that this phenomenological model can give insight on the influence of environment on the inner sub-Keplerian accretion disc.
Enhancing precision in quantification and spatial distribution of logging residues in plantation stands
Authors: Udali Alberto , Talbot Bruce , Ackerman Simon , Crous Jacob , Grigolato Stefano 
Published: December 2023

Abstract
Forests, essential components of ecosystems, are managed for sustainable timber production in forest plantations to meet the growing demand for wood products. The intricate balance between sustainable forest management and logging residue practices is crucial for ecological integrity and economic viability. Logging residues, byproducts of timber harvesting, significantly influence carbon and nutrient cycling, soil structure, and overall ecosystem health. Recent technological advancements, particularly the use of drones integrated with artificial intelligence, enable the processing of large datasets, providing meaningful insights into logging residues and forest dynamics. This study aims to evaluate the quantification and distribution of logging residues in forest plantations, utilizing machine learning classification models fed with drone-based images. The classification was performed using a Random Forest model fed with spectral and terrain variables, whereas the volume estimations were derived from field measurements and from the drone classification. Overall the classification achieved solid results (Overall Accuracy of 0.89), and the volume estimation resulting in solid comparison with field estimation (ratio 0.43–1.37), but poor correlation (R2 of 0.17 and 0.31). We concluded that the proposed methodology is suitable for classifying and assessing residues distribution over recently harvested areas, but further improvement of the volume estimation methodology is necessary to ensure comprehensive and precise assessment of residue distribution over recently harvested areas.