bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of widespread annular secondary syphilis: An unusual instance
Authors: Choubey Shini , Sethy Mitanjali , Mishra Jeebanjyoti , Raj Chinmoy , Panda Sibaram 
Published: January 2025

Abstract
Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, is a globally significant health concern. While the disease is well known for its diverse clinical manifestations, its presentation can be particularly challenging, especially in immunocompromised individuals or those with comorbidities. This case report highlights an unusual presentation of secondary syphilis in a hepatitis B-positive patient, characterized by widespread annular lesions.
Pigmented fungus as a cause of chronic otitis externa: A rare case report
Authors: Macwan Pankti , Mohanty Madhusmita , Singh Ajit Kumar , Giri Ranjana 
Published: January 2025

Abstract
A sporadic infection by a pigmented fungus called chromoblastomycosis is seen in tropical and subtropical climates. It can affect lower extremities most commonly followed by upper extremities. Here, we report an unusual case of chromoblastomycosis causing otitis media in a young female. The ear is an uncommon site of involvement. She presented to the ear, nose, and throat outpatient department with a complaint of left earache for 1 week. On ear examination, the external auditory canal was occluded by debris. Debridement was done from the lesion and was sent for histopathological examination which revealed granulation tissue and fungal spores. Special stains were used to identify the fungus and the patient was treated with antifungals. We report this case to conclude that chromoblastomycosis though rare should be considered as one of the etiologies for otitis externa.
Stemless shoulder arthroplasty in the young: A case report and literature review
Authors: Sondur Suhas , Sarkar Sayantan , Mishra Debashish 
Published: January 2025

Abstract
Shoulder arthroplasty has undergone significant evolution, with the development of stemless shoulder prostheses representing a paradigm shift. This case description is of a 43-year-old young male with osteoarthritis of the right shoulder who underwent stemless shoulder arthroplasty. The patient presented with persistent right shoulder pain and restricted range of motion. Radiographic and magnetic resonance imaging findings confirmed shoulder osteoarthritis. The patient underwent a standard deltopectoral approach for stemless total shoulder arthroplasty. The subscapularis tendon was anatomically repaired. Postoperatively, the patient underwent a structured rehabilitation program, achieving a near-normal range of motion and significant pain improvement at the 6-month follow-up. Radiographic evaluation showed a well-positioned implant with no signs of loosening. The use of stemless implants in shoulder arthroplasty offers several potential advantages, including bone preservation and reduced surgical complications. However, appropriate patient selection and meticulous surgical technique are crucial, as long-term outcomes data are still limited. This case demonstrates the feasibility and short-term success of stemless shoulder arthroplasty in a relatively young patient with osteoarthritis. Ongoing research is focused on optimizing implant design and expanding indications for this innovative approach. A long-term follow-up studies will be essential to fully assess the durability and potential limitations of stemless shoulder arthroplasty.
Localized pityriasis rosea: A case series with review of the literature
Authors: Reddy Vinisha Vintha , Behera Debasmita , Raj Chinmoy , Begum Farheen 
Published: January 2025

Abstract
Pityriasis rosea (PR) is a self-limiting inflammatory skin condition primarily affecting adolescents, with a slight female predominance. It typically presents with a herald patch followed by smaller lesions in a characteristic “Christmas tree” distribution. Uncommon presentations localized to atypical sites are rarely reported. This case series highlights the potential for PR to present in atypical localized patterns. Dermatologists should consider PR in the differential diagnosis of localized erythematous plaques and rely mostly on histopathological confirmation for accurate diagnosis.
Evaluating the Effectiveness of Virgin Coconut Oil Effleurage in Alleviating Pain in Hemodialysis Patients with Chronic Kidney Disease: A Study in an Urban Tertiary Care Center in South India
Authors: Angelina Kirubakaran Amutha , Vaithilingan Sasi , Ragunathan Latha , Kannan Vetriselvi 
Published: January 2025

ABSTRACT

Background:
The study investigates the impact of effleurage massage using coconut oil on pain in chronic renal failure (CRF) patients undergoing hemodialysis. The research aims to explore the potential therapeutic benefits of this intervention in alleviating pain associated with hemodialysis.

Methods:
A quasi-experimental design was used, with 150 individuals with mild to moderate leg discomfort aged 30–70 chosen. The Wong–Baker pain scale was used for pretest. After a month, a posttest was conducted.

Results:
Results showed that 70% of the patients had moderate levels of leg pain, while 30% had mild pain. After the intervention, 36% had no pain, 42% had mild pain, and 22% had moderate pain.

Conclusion:
The study concluded that effleurage massage with coconut oil is effective in reducing leg pain among CRF patients undergoing hemodialysis.
Assessing Knowledge and Attitudes Regarding Organ Donation among Medical Students in South India: A Cross-Sectional Study
Authors: Ragupathy Sreekumar , Sadasivam Kanimozhi , Thirumalai Raju Prasath , Kanagaraj Thamarai Selvi , Ayyavoo Saravanan 
Published: January 2025

ABSTRACT

Background:
This research assesses the level of knowledge and attitudes of medical students in South India on organ donation and transplantation, focusing on cultural and psychological barriers that hinder these practices, especially in developing regions.

Methods:
The cross-sectional research was carried out at SRM Medical College and Hospital and Research Centre in Chennai, Tamil Nadu, involving 207 undergraduate medical students. Data were collected through a structured questionnaire, evaluating knowledge and attitudes toward organ donation. The Knowledge Subscale contained 13 questions, while the Attitude Subscale had 13 items rated on a five-point Likert scale.

Results:
The study found that 57.59% of participants were female and aged 18–21, with 97.58% aware of organ donation and the “Transplantation of Human Organs Act.” However, only 7.73% knew where to obtain donation cards. Attitudes toward organ donation were mixed, with discomfort and religious beliefs being significant barriers. Concerns about body disfigurement and premature medical treatment persisted.

Conclusion:
The study emphasizes the need for educational interventions to improve medical students’ understanding and attitudes toward organ donation in South India, considering demographic, personal, and cultural factors, and suggests a multifaceted approach for community engagement.
The Efficacy of Benson Relaxation for Managing Psychological Distress in Primipostpartum Women: A Systematic Review
Authors: Lakshmi Munusamy , Naganandini Raju 
Published: January 2025

ABSTRACT

Background:
The Benson Relaxation Technique, a mind-body approach, has been proposed as an effective intervention for prime-postnatal mothers to alleviate stress, anxiety, and depression.

Objective:
The study aims to comprehensively analyze and synthesize the existing literature on the influence of the Benson Relaxation Technique on psychological factors such as stress, anxiety, and depression among primi-postnatal mothers.

Methods:
A literature search spanning 2013-2024 analyzed studies on Benson Relaxation Technique’s impact on psychological parameters in primi-postnatal mothers, assessing changes in these parameters through validated scales.

Results:
The Benson Relaxation Technique significantly reduced stress, anxiety, and depression in primi-postnatal mothers, with some studies showing moderate to large effects.

Conclusion:
The Benson Relaxation Technique, a potentially effective intervention for reducing stress and anxiety in postnatal mothers, warrants further research for its long-term effects and mechanisms.
Role of Genetic Mutations in Periodontitis Patients with Cardiovascular Diseases and Allied Ailments: A Systematic Review and Meta-analysis
Authors: Yatham Pragathi , Jaideep Mahendra , Ramadevi V. , Pogula Asha L. , Periasamy Panneerselvam 
Published: January 2025

ABSTRACT

Background:
Periodontal disease, a chronic inflammatory condition, has been increasingly associated with systemic health issues, particularly cardiovascular diseases. This systematic review and meta-analysis explores the role of genetic mutations in periodontitis patients with cardiovascular diseases and allied ailments.

Methodology:
Conducted a comprehensive search across databases including PubMed, EMBASE, and Cochrane Library to identify relevant studies on the association between genetic mutations, periodontal disease severity, and cardiovascular outcomes. Sixteen studies met the inclusion criteria, primarily comprising observational studies with varying levels of risk of bias.

Results:
Our analysis revealed that specific genetic mutations, such as those in TLR 2, TLR 4, NF-kB, and IL-4 genes, significantly increase the risk of periodontitis and exacerbate cardiovascular conditions like coronary artery disease, myocardial infarction, and stroke. These findings underscore the importance of integrating genetic screening into the management of periodontal and cardiovascular diseases. The results also emphasize the need for interdisciplinary collaboration between dental and medical professionals to develop personalized treatment strategies.

Conclusion:
In conclusion, genetic mutations play a pivotal role in the susceptibility and severity of periodontitis in patients with cardiovascular diseases. Understanding these genetic factors could lead to improved diagnostic tools and therapeutic approaches, addressing the dual burden of periodontal disease and cardiovascular ailments. Future research should focus on large-scale, longitudinal studies to further elucidate the molecular mechanisms and develop targeted interventions for these interconnected health issues.
A Comparative Analysis of Diagnostic Accuracy: Vibration Perception Threshold vs. Diabetic Neuropathy Examination for Diabetic Neuropathy
Authors: Subramani Arulmozhi , Periasamy Panneerselvam , Gunasekaran Sasikala 
Published: January 2025

ABSTRACT

Background:
Diabetes mellitus has emerged as a global health crisis, with its prevalence escalating dramatically. Diabetic peripheral neuropathy (DPN) stands out as one of the most frequent complications, leading to significant morbidity, including foot ulcers and amputations, if not identified and managed promptly. Effective screening methods are essential for early detection, which can significantly improve patient outcomes and reduce the risk of severe complications.

Aim and Objectives:
This study aims to evaluate the sensitivity and specificity of the Diabetic Neuropathy Examination (DNE) score in comparison to the vibration perception threshold (VPT) test. Both methods will be assessed individually and in combination to determine their effectiveness in diagnosing DPN among patients with diabetes. The study also seeks to establish a correlation between these screening tests.

Materials and Methods:
A case-control study was conducted involving 100 subjects, comprising 50 patients diagnosed with DPN and 50 healthy controls. The participants were aged between 30 and 70 years, and various parameters such as fasting blood sugar, anthropometric measurements, DNE scores, and VPT readings were recorded. Ethical clearance was obtained, and informed consent was secured from all participants.

Results:
The findings indicated that the DNE score demonstrated a sensitivity of 80% and a specificity of 73.33%, while VPT exhibited a sensitivity of 70% and a specificity of 86.67%. When both tests were combined, the sensitivity increased to 90%, highlighting the potential for enhanced diagnostic accuracy through a multimodal approach.

Conclusion:
The DNE score, when utilized alongside VPT, provides a robust framework for the early detection of DPN, particularly in community settings where resources may be limited. This study underscores the importance of integrating simple, effective screening techniques into routine clinical practice to mitigate the risks associated with diabetic complications.
Radiographic Assessment of the Marginal Bone Loss Around the Implant Before and After the Prosthesis Placement—A Comparative Study
Authors: Jalaluddin Mohammad , Rathod Aradhana , Mailankote Shilpa , Bipinchandra Liya Neha , Raj BS Harsha , Ahirwar Anupama 
Published: January 2025

ABSTRACT

Aim:
The present investigation performed the CBCT to measure the marginal bone loss surrounding the implant both before and after the prosthesis was placed.

Materials and Methods:
Within the age range of 21 to 45 years, a total of 20 patients were involved, and all participants gave their informed consent. Immediate implant was inserted and ceramic prosthesis was prepared and given to the patients. Radiographic assessment was carried out using the CBCT at baseline, three months, and six months following the prosthesis. The circumference of the crestal bone level around the implant was measured in all directions (mesial, distal, buccal, and palatal), using the implant’s first thread as a standard reference point.

Results:
The change of the mean marginal bone level at the time of implant placement to three months after the prosthesis was at mesial 1.32 ± 0.02 to 1.46 ± 0.10, at distal 1.46 ± 0.08 to 1.94 ± 0.14, at buccal 1.28 ± 0.01 to 1.40 ± 0.06, at palatal 1.20 ± 0.03 to 1.22 ± 0.04. The change of the mean marginal bone level at the time of implant placement to six months after the prosthesis was at mesial 1.32 ± 0.02 to 1.84 ± 0.12, at distal 1.46 ± 0.08 to 2.38 ± 0.02, at buccal 1.28 ± 0.01 to 1.78 ± 0.04, at palatal 1.20 ± 0.03 to 1.34 ± 0.01.

Conclusion:
The current investigation came to the conclusion that the CBCT provides all the diagnostic information required for an implant to be placed successfully.
Effect of MMP Inhibitors on Shear Bond Strength of Adhesive to Dentin after Different Drying Techniques: An In-Vitro Study
Authors: Narayanan Sheethal K. , Hari Krishnan , Mathew Joy , Sukumaran Anila , Joy Basil , Mathew Joel 
Published: January 2025

ABSTRACT

Background and Objective:
Instead of excessive drying or wetness, maintaining an optimal moisture level on the dentin surface may enhance the polymerization process of certain monomers. The study was intended to contrast and evaluate the effect of Matrix metalloproteinases (MMPs) inhibitors (Chlorhexidine (CHX) and Doxycycline (DOX)) on the shear bond strength (SBS) of adhesive dentin interface after different drying techniques (blotting with tissue paper (TP) and damp cotton pellet (CP)).

Materials and Methods:
Ninety molars collected were split into three groups according to the materials used during the acid etching step: Group A (control): 37% phosphoric acid only; Group B: 37% phosphoric acid followed by 2% CHX; Group C: 37% phosphoric acid followed by 2% DOX. Each group was categorized into 2 subgroups based on the drying methods used after etching (TP and damp CP). A universal bonding agent was applied after this and composite restoration was placed onto the dentin and cured. The samples underwent thermocycling for 500 thermocycles for degradation of the adhesive surface. The SBS of the specimens was appraised with a universal testing machine until fracture.

Results:
The CHX group blotted with TP (20.98 ± 0.29 MPa) had the highest SBS among the study sample. This was eventually followed by the CHX group blotted with the CP (18.99 ± 0.28 MPa), DOX blotted with TP (19.73 ± 0.51 MPa), and DOX blotted with the CP (17.09 ± 0.55 MPa). The least SBS was observed in the control group blotted with TP (16.9 ± 0.22 MPa) and then by CP (13.78 ± 0.55 MPa).

Conclusion:
The study showed that CHX had a superior effect on the SBS when compared to DOX. Among the drying agents used TP yielded better results than drying with a damp CP. The overall SBS was high in the CHX group dried with TP and the least strength was shown by the control group where treatment with an MMP inhibitor was done.
Evaluating Anti-ESKAPE Potential of Valeriana Officinalis L. Extract against Healthcare-Associated Infections in Tertiary Hospitals of Al-Kharj Governorate: An In Vitro Study
Authors: Khan Mohammed S. , Bari MD Nadeem 
Published: January 2025

ABSTRACT

Background:
Healthcare-associated infections (HAIs) caused by ESKAPE pathogens are a significant concern in tertiary hospitals worldwide, including those in Al-Kharj, Saudi Arabia. This study aimed to explore the bioactive compounds from Valeriana officinalis and evaluate their antimicrobial activity against ESKAPE pathogens.

Materials and Methods:
Methanolic extracts of the Valeriana officinalis stem were prepared and subjected to phytochemical analysis, thin-layer chromatography (TLC), and antimicrobial testing using the well-diffusion method. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and cytotoxicity (MTT assay) were also evaluated.

Results:
The extract contained several major phytochemicals with significant activity against ESKAPE pathogens. The MIC values were 50 mg/mL for Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, 100 mg/mL for Enterococcus faecalis and Staphylococcus aureus, and 25 mg/mL for Escherichia coli. The MBC values were 25 mg/mL for Escherichia coli and 100 mg/mL for the other ESKAPE pathogens.

Conclusion:
The methanolic extract of Valeriana officinalis L. demonstrated potent antimicrobial activity, with relatively low MIC and MBC values against ESKAPE pathogens responsible for HAIs.
Colchicine in the Management of Oral Submucous Fibrosis – A Systematic Review and GRADE Assessment
Authors: Chellapandian Naveenaa , Sekizhar Vandana , Ammayappan Pavithranand , Srivastava Kumar Chandan , Nagy Ahmed Ismail Abdelrahman , Kengadaran Shivashankar , Heboyan Artak , Shrivastava Deepti 
Published: January 2025

ABSTRACT

Background and Objectives:
Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder affecting the oral mucosa. The habit of areca nut chewing is established to be the causative factor. Various treatment modalities are available for managing OSMF. Colchicine obtained from plants of the Colchicum genus can downregulate collagen synthesis and upregulate collagenolytic activity, thereby establishing its antifibrotic property. Hence, the objective of the current study is to assess the efficacy of colchicine in the treatment of OSMF.

Methods:
A comprehensive search was conducted in MEDLINE via PubMed, Cochrane, ProQuest, Ovid, and Google Scholar, and the clinical trials evaluating the efficacy of oral colchicine for the treatment of OSMF were included. The Cochrane risk of bias tool and GRADE were utilized for assessing the quality.

Results:
Three clinical trials (one randomized and two non-randomized trials) comprising 110 OSMF patients followed the eligibility criteria. The follow-up time for the patients was between 3 and 6 months. Mouth opening and burning sensation were the primary outcomes of interest. The risk of bias was found to be high in the studies included. GRADE quality assessment showed moderate quality for one study and two studies to be of low-quality evidence.

Conclusion:
This review suggests that oral colchicine is efficacious in the management of OSMF and more distinctly in improving mouth opening. Considering the significant side effects from conventional treatment for OSMF, colchicine can be an effective modality in improving burning sensation and mouth opening in patients with OSMF.
Comparative Efficacy of Conventional Versus Diode Laser Assisted Root Canal Treatment in Reduction of Postoperative Pain and Healing of Periapical Lesion: A Randomized Controlled Clinical Trial
Authors: Dubey Priyanka , Savita Anjali , Khan Ruba , Saxena Rupal , Dubey Kriti , Verma Purva 
Published: January 2025

ABSTRACT

Background:
Laser assisted root canal treatment has emerged as a promising adjunct to conventional randomized controlled trials (RCTs).

Material and method:
To evaluate the same, we observed 90 patients (98 roots) with chronic periapical lesions; they were randomized into two groups (n = 45): diode laser and control. The level of pain was measured before and at 6, 12, 24, 48, and 72 hours after treatment using a visual analog scale. Cone beam computed tomography images were obtained before and 6 months after treatment to assess the healing of periapical lesions based on their apicocoronal, mesiodistal, and buccolingual diameters.

Result and conclusion:
It was observed that root canal disinfection by diode laser significantly decreased the postendodontic pain and resulted in a higher success rate in lesion resolution.
Identification of Filifactor Alocis in Periodontal Biofilms using Polymerase Chain Reaction Technique: A Cross-Sectional Study
Authors: Poorana Kaliaperumal , Lavanya Nallasivam , Rekha Munuswamy Jeeva , Maheaswari Rajendran 
Published: January 2025

ABSTRACT

Background and Aim:
Contribution of organisms causing periodontal disease remains unclear. Strong association has emerged between the presence of gram-positive Filifactor alocis (F.alocis) and periodontitis. Hence, we aimed to identify the presence of F.alocis in periodontal biofilms through PCR technique in health and disease.

Settings and Design:
A cross-sectional study was conducted among 45 participants divided into three equal groups based on their periodontal conditions, namely, healthy, generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAP).

Methods and Materials:
Subgingival plaque samples were obtained, and real-time PCR was used to identify the presence of F.alocis. The clinical parameters, plaque index, sulcus bleeding index, probing pocket depth, and clinical attachment level were determined.

Statistical Analysis:
The statistical analysis was done using the software SPSS (Statistical package for social science). All the data were analyzed using the ANOVA test.

Results:
The difference between mean plaque index, sulcus bleeding index, probing pocket depth, and clinical attachment level was statistically significant between healthy and periodontitis (chronic and aggressive) sites. F.alocis was identified in all samples. The mean cycle threshold (CT) values of healthy, GCP, and GAP were 38.01, 30.85, and 28.92, respectively, and the results are statistically significant.

Conclusion:
The load of organism was significantly higher in the GAP group followed by the GCP group and lowest in the healthy group. Bacterial load was highest in teeth with deep pockets. Hence, F.alocis seems to be a powerful diagnostic marker organism for periodontal disease, and it should be considered an important periodontal pathogen.
Various Methods for Measuring Gingival Thickness – A Comparative Analysis of Three Different Methodologies
Authors: Pati Ankita , Manohar Balaji , Kaur Awneet , Sagar Snigdha , Sharma Shruti , Bhuvaneshwari S. 
Published: January 2025

ABSTRACT

Introduction:
Measuring gingival thickness (GT) is crucial in periodontal and implant dentistry as it impacts clinical decisions and outcomes.

Materials and methods:
Several methods are employed to assess GT, including conebeam computed tomography (CBCT), transgingival probing, and ultrasonography. Each technique has distinct advantages and limitations in terms of accuracy, invasiveness, and practical application.

Results:
This study has established that transgingival probing is the gold standard technique for measuring GT.