bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ein schwieriges Feld: Betriebliche Gesundheitsförderung in
der stationären Altenpflege
Authors: Huber Gerhard , Peters Stefan , Weiß Klaus 
Published: October 2023

ZusammenfassungDas Aufsuchen in Betrieb und Arbeitsplatz ist für viele Menschen die
einzige Option, um sie mit dem Thema
„Gesundheitsförderung“ zu erreichen. Dies gilt besonders
für das Arbeitsfeld der stationären Altenpflege, da wir
denjenigen, die für die Gesundheit und Pflege anderer Menschen sorgen,
besondere Aufmerksamkeit widmen sollten. Die hohen Arbeitsbeanspruchungen und
die hohen Arbeitsunfähigkeitszahlen wurden im Rahmen des Projekts POLKA
ausführlich analysiert und an anderer Stelle publiziert.Das POLKA-Projekt ist durch den Einsatz professioneller Lotsen und Experten zur
Implementation gekennzeichnet. In Ergänzung zu den quantitativen
Forschungsansätzen wurden deren konkrete Erfahrungen und Erkenntnisse
qualitativ durch semi-strukturierte Interviews erschlossen. Die
computergestützte Auswertung der Interviews ergab einen substantiierten
Einblick in die Förderfaktoren und Barrieren der Projektumsetzung. Die
Adhärenz der Mitarbeiter sowie die Heimleitung konnten als relevante
übergeordnete Kategorien, für die Handlungsbedarf besteht,
identifiziert werden. Dies wird differenziert dargestellt.
Morbidity in Patients with Chronic Adrenal Insufficiency –
Cardiovascular Risk Factors and Hospitalization Rate Compared to Population
Based Controls
Authors: Burger-Stritt Stephanie , Hahner Stefanie , Chifu Irina , Quinkler Marcus , Altieri Barbara , Hannemann Anke , Völzke Henry , Lang Katharina , Reisch Nicole , Pamporaki Christina , Willenberg Holger Sven , Beuschlein Felix 
Published: October 2023

AbstractPatients with adrenal insufficiency (AI) have been found to have increased
cardiovascular morbidity, partly associated with nonphysiologic glucocorticoid
replacement. We included two separate cohorts (cohort 1 n=384 patients,
cohort 2 n=180 patients) of patients with chronic primary and secondary
AI under standard replacement therapy and compared them to two age- and
sex-matched population-based studies (SHIP-TREND/DEGS). Odds ratios with
95% CI for hypertension, hyperlipidemia/HLP, type 2
diabetes/T2DM, obesity, and hospitalization with adjustment for
confounders were evaluated by logistic regression. Patient cohort 1 had
significantly lower ORs for obesity [0.4 (0.3–0.6), p<0.001] and
hypertension [0.5 (0.3–0.6), p<0.001] compared to SHIP-TREND and
for obesity [0.7 (0.5–0.9), p=0.01], hypertension [0.4
(0.3–0.5), p<0.001] and HLP [0.4 (0.3–0.6),
p<0.001] compared to DEGS. In cohort 2, ORs were significantly lower for
HLP compared to both SHIP-TREND [0.4 (0.2–0.7), p=0.001] and
DEGS [0.3 (0.2–0.5), p<0.001] and for hypertension [0.7
(0.4–0.9), p=0.04] compared to SHIP-TREND. In patients with SAI
from cohort 2, ORs for DM2 [2.5 (1.3–4.9) p=0.009], hypertension
[2.5 (1.4–4.5), p=0.002] and obesity [1.9 (1.1–3.1),
p=0.02] were significantly higher compared to DEGS, whereas ORs for HLP
were significantly lower compared to both SHIP [0.3 (0.1–0.6),
p=0.002] and DEGS [0.3 (0.1–0.6), p<0.001]. In most of
our AI patients treated with conventional glucocorticoid doses, the risk for
T2DM, obesity, hypertension, and HLP was not increased. The number of
hospitalizations was significantly higher in AI patients compared to controls,
which might reflect increased susceptibility but also a more proactive
management of concomitant diseases by physicians and patients.
Effect of Health Insurance Status and Visitation Restrictions on Virtual Visitation Technology in the Neonatal Intensive Care Unit
Authors: Henderson-Sears Susan E. , Stefanescu Andrei R. , Stefanescu Beatrice M. , Allen Jayme D. 
Published: October 2023

Objective This study aimed to examine the relationship between virtual technology system utilization and insurance status or type of visitation restrictions in a single-center neonatal intensive care unit.
Study Design Prospective cohort study with separate analyses performed based on insurance status (public vs. nonpublic) and “in effect” unit visitation restrictions. The three study epochs based on patient visitation restrictions were Epoch 1 (July to October 2019) with standard visitation restrictions, Epoch 2 (November 2019 to February 2020) with respiratory syncytial virus/influenza visitation restrictions, and Epoch 3 (March to June 2020) with coronavirus disease 2019 (COVID-19) visitation restrictions, respectively.
Results Families of 357 infants used web-based cameras through most of the infant's hospitalization (median: 86.05%, Q3: 97.9%) with 165,795 total camera logins, indicating consistent utilization. There was a trend for fewer logins per infant and significantly longer time to consent (p = 0.03) in the Public Insurance group. Unit visitation restrictions impacted the time to consent, the shortest being in Epoch 3 during the COVID-19 pandemic (p = 0.03).
Conclusion Virtual visitation technology is well embraced by neonatal instensive care unit families; however, gaps in access and use among subgroups signals a form of social inequality that needs to be explored further.
Key Points
Platelet Activation is Upregulated in Cirrhotic Patients with Portal Vein Thrombosis
Authors: Zhao Fazhi , Ding Jingnuo , Cui Juanjuan , Zhu Mingqing , Zhao Weifeng 
Published: October 2023

Objective Platelet plays a key role in thrombosis formation, especially that the alteration of platelet function may influence the thrombosis development. This study aimed to investigate platelet function alterations in the formation of portal vein thrombosis (PVT) in cirrhosis.
Methods Cirrhotic patients admitted to The First Affiliated Hospital of Soochow University between October 2021 and April 2023 were recruited and divided into PVT and non-PVT groups according to radiological results. Clinical parameters and prognosis were also collected and assessed to identify potential risk factors. Flow cytometry was used to detect the expression of CD62p, CD63, monocyte–platelet aggregates (MPAs), neutrophil–platelet aggregates (NPAs), and von Willebrand factor antigen (vWF-Ag) to evaluate platelet activation and adhesion function.
Results A total of 145 subjects were enrolled in our study including 60 cirrhotic PVT patients, 60 cirrhotic non-PVT patients, and 25 healthy volunteers. Multivariate analysis suggested that esophageal gastric varices, splenectomy, and D-dimer were independent risk factors for PVT pathogenesis in cirrhosis. The vWF-Ag expression level was reduced in the PVT group compared with the non-PVT group (p = 0.046) but was not an independent risk factor for PVT formation pathogenesis. The expression of CD41+CD62p+ and CD41+CD63+ platelets in the PVT group was significantly elevated compared with that in the non-PVT group (p < 0.05). There were no significant differences in MPAs and NPAs between the two cirrhotic groups. Subgroup analysis showed that the mean fluorescence intensity (MFI) of CD62p and CD63 was associated with portal hypertension-related complications (p = 0.008, p < 0.001), and CD63 MFI was significantly associated with thrombosis burden (p = 0.019). CD41+CD62p+ and CD41+CD63+ platelets as well as MPAs and NPAs were highly expressed in the splenectomy group compared with those in the nonsplenectomy group in cirrhotic patients (p < 0.05). Positive correlations were found between CD62p MFI and CD63 MFI, MPAs and NPAs (r = 0.642, p < 0.001; r = 0.378, p = 0.003; r = 0.430, p < 0.001). In addition, platelet counts were also correlated with MPAs (r = 0.556, p < 0.001) and NPAs (r = 0.467, p < 0.001). Cirrhotic patients with PVT had higher mortality and were more likely to experience portal hypertension-related complications in the prognostic analysis (p < 0.05).
Conclusion Highly activated platelet function exists in patients with cirrhosis, and platelet activation was elevated during PVT formation, suggesting that activated platelets may participate in the formation of PVT in patients with cirrhosis.
Distinctive Amplitude-Integrated EEG Ictal Pattern and Targeted Therapy with Carbamazepine in KCNQ2 and KCNQ3 Neonatal Epilepsy: A Case Series
Authors: Vilan Ana , Grangeia Ana , Ribeiro José Mendes , Cilio Maria Roberta , de Vries Linda S. 
Published: October 2023

Abstract
Background Carbamazepine (CBZ) is effective in treating KCNQ2/3-related seizures, which may present with a distinctive amplitude-integrated electroencephalography (aEEG) pattern.
Objective To assess how improved recognition of the distinctive aEEG ictal pattern associated with KCNQ2/3 variants has enabled early and effective targeted therapy with CBZ.
Methods Retrospective descriptive study of five neonates with KCNQ2/3 pathogenic gene variants admitted at a level 3 neonatal intensive care unit (NICU) over an 8-year period.
Results The distinctive ictal aEEG pattern was recognized in four neonates after an average of 61.5 hours (minimum 12 hours, maximum 120 hours) from the first electroclinical seizure and prompted the use of CBZ that was effective in all. The two most recently diagnosed patients could avoid polytherapy as they received CBZ as the first and second antiseizure medication, respectively. Three out of five patients with continuous normal voltage (CNV), sleep–wake cycling (SWC), and shorter postictal suppression had normal neurodevelopmental outcome. Regarding the remaining two infants, one was not trialed with CBZ and had a high seizure burden, both presented with a prolonged postictal suppression, no SWC, and had moderate-to-severe developmental delay. Genetic results became available after the neonatal period in all but one of the infants, who had a prenatal diagnosis.
Conclusion Recognition of the distinctive ictal aEEG pattern in the NICU allowed early and effective targeted therapy with CBZ in four neonates, well before genetic results became available. Furthermore, a CNV background pattern with SWC and short postictal suppression were associated with normal developmental outcomes.
The Assessment and Management of Childhood Masturbation: An Analysis of 90 Cases
Authors: Güleç Ayten , Öztürk Selcan , Acer Hamit , Canpolat Mehmet , Gümüş Hakan , Per Hüseyin 
Published: October 2023

Abstract
Aim The child's self-stimulating pleasure behavior is defined as childhood masturbation (CM). Diagnosis of CM is mainly based on behavior and analysis of video recordings. This study aims to investigate etiological factors, movement patterns, and treatment options.Medical records and video recordings of CM in our clinic between 2015 and 2020 were retrospectively reviewed.
Results Ninety patients aged 8 months to 9 years were included in our study. The male-to-female ratio was 23/67. The mean age at onset of masturbation (mean ± standard deviation) was 21.42 ± 18.44 (6–107) months. Note that 27.7% (32) of the patients were taking antiepileptic drugs before admission.Eight of the 90 patients had abnormal electroencephalograms. The time of onset of CM was related to cessation of breast milk in 24.4%, separation from the mother in 43.3%, new siblings in 16.6%, initiation of toilet training in 7.7%, and parental divorce in 6.6%. Behavioral therapy was sufficient in 71.1%. Hydroxyzine hydrochloride in 19 (21.1%) and risperidone in 9 (10%) were given in the remaining cases. Overall, 23/28 of the cases receiving medication improved during follow-up.
Conclusion Physicians may have difficulty identifying repetitive movements in CM. Misdiagnosis or delayed diagnosis may lead to unnecessary use of antiepileptic drugs, delayed initiation of treatment, and prolonged treatment duration. Video recordings are important in the differential diagnosis of CM. CM may have psychosocial causes and can often be effectively treated with behavioral therapy. Pharmacological treatment (hydroxyzine hydrochloride and risperidone) may be considered in cases that do not respond to behavioral treatment.
Profile of Enteric Fever in Children Admitted to a Tertiary Care Center in North India
Authors: Joshi Disha , Gupta Veenu , Bhat Deepak , Gupta Menal , Dhooria Gurdeep Singh 
Published: October 2023

Background Enteric fever is a community-acquired systemic infection which is more common in resource-limited overcrowded communities with poor access to sanitation and its management is compounded by the increasing antimicrobial resistance to the first-line antibiotics used.
Materials and Methods This descriptive study reports the clinical profile of children with enteric fever managed at the departments of pediatrics and microbiology of a tertiary care hospital from February 2020 to August 2021. All inpatients who were confirmed (blood culture positive) or probable cases (clinical and serological evidence by Widal test) of enteric fever were included. Profile of all cases and antibiotic sensitivity pattern in culture positive cases were studied.
Results Of the 70 cases enrolled, 40% were females and 60% males, and majority (52.9%) was in the age group of > 5 years. At admission, fever was the most common presentation along with abdominal symptoms. Widal test was positive in 84.6% cases and was found to be 80% sensitive when compared to the gold-standard blood culture. Both Salmonella Typhi (74.3%) and S. Paratyphi (12.9%) isolates were 100% sensitive to azithromycin, cotrimoxazole, and ceftriaxone. Quinolones and second-generation cephalosporin cefuroxime showed high resistance in comparison. None of the isolates was multidrug resistant. All cases were discharged after successful treatment.
Conclusion The burden of disease and antibiotic susceptibility of enteric fever needs to be monitored to guide clinicians in selection of antibiotics.
Evaluation of the contamination droplet model used for the assessment of skin dose during the manipulation of radiopharmaceuticals
Authors: Wicks Sarah , Heraghty Neil 
Published: October 2023

Abstract
The manipulation of radiopharmaceuticals in nuclear medicine can result in the droplet contamination of operators resulting in the accumulation of a significant skin dose. Current methods to estimate this skin dose often utilise a 50 μl cylindrical droplet model, which can lead to unrealistically high estimated skin doses for some radiopharmaceuticals. By conducting experiments to measure the volume of real droplets arising from simulating the manipulation of radiopharmaceuticals, this work found that 50 μl is an overestimation of a realistic contamination droplet. For almost all radiopharmaceuticals considered in this work, incorporating a smaller droplet volume into skin dose simulations resulted in higher estimates of skin dose rate per unit of activity, which, when combined with appropriate activity concentrations and droplet volumes, resulted in lower skin doses for contamination droplet incidents. The results presented in this work challenge the 50 μl contamination droplet volume and highlight the importance of having an accurate model when estimating the skin dose for contamination scenarios.
Micromagnetic and quantitative prediction of yield strength and tensile strength in DP590 steels based on ReliefF + Clustering feature selection method
Authors: Wang Xianxian , He Cunfu , Li Peng , Liu Xiucheng , Xing Zhixiang , Zhang Yangyang , Li Jinrun 
Published: October 2023

Abstract
The correlation between multiple patterns of micromagnetic signatures and the mechanical properties (yield strength (Rp) and tensile strength (Rm) of high-strength steel (referred to as DP590 steel in Chinese standards) was investigated in this study. Feedforward neural network (FF-NN) models with carefully selected magnetic features as input nodes were established for quantitative prediction of yield strength and tensile strength. The accuracy FF-NN models highly relied on the quality of calibration specimens and the way of selecting magnetic features. The variations of the measured target properties were used to evaluate the quality of the calibration specimens. The specimens with similar yield strength (or tensile strength) were merged to share the same target properties in the model training process. The results demonstrated that merging proper target properties (label) could improve the performance of the models in quantitative prediction of yield strength and tensile strength in DP590 steels. In addition, the performances of FF-NN models combined with the algorithms of ReliefF and ReliefF + clustering were evaluated. The comparison results proved that the FF-NN models employing input nodes selection strategy of ReliefF + clustering realized the advantages of smaller dimensions of input nodes, less training time consumption at the cost of slight accuracy reduction.
Online detection of analog signal anomaly based on the evaluation of local trends
Authors: Liu Yufang , Jiang Bin , Yi Hui 
Published: October 2023

Abstract
Online anomaly detection (AD) of analog signals plays an important role in equipment fault diagnosis and predictive maintenance. However, the signal often deviates slightly from those seen previously in the early stage of equipment failure, and the anomaly is invisible to the human eye. This kind of anomaly belongs to the typical contextual anomaly. Whether this anomaly can be effectively detected determines whether the failure of the equipment can be detected in the early stage, which is of great significance for safety in production. This study aimed to propose an online AD method for the analog signals of the quasi-sine waveform class. The sample similarity in the sliding window was evaluated using a sample trend rather than sample amplitude deviation to detect anomalies based on the principle that the trend of the quasi-sinusoid waveform signal in the adjacent space was similar. Compared with the traditional method, the proposed method was sensitive to contextual anomalies and did not need a complete sample data set for model training. The proposed method was finally validated by three data sets with good results.
Ag–N–C single atom catalyst with resistance for Ag loss in acetylene hydrochlorination
Authors: Liu Li , Lu Fangjie , Yin Xue , Yao Yuqi , Zhu Mingyuan , Dai Bin 
Published: October 2023

Abstract
Ag–N–C catalyst was synthesized by the calcination process with AgNO3 as precursors, active carbon as support, and melamine as an N source. Series of characterizations showed that Ag was transferred into AgCl during the active phase by HCl, and pyridinic structure in the support was bonded with Ag components. Then, Ag–N–C single atom catalyst (SAC) was obtained by washing Ag–N–C with acid, aberration-correction high-angle-annular-dark-field scanning transmission electron microscopy showed that Ag presented in single atoms form, and Ag coordinated with the nitrogen atom in the support. Ag loss rate for Ag–N–C SAC was only 0.09% after running 10 h in acetylene hydrochlorination process, which was much smaller than Ag–N–C (57%), indicating that the presence of the Ag–N bond could be inhibiting Ag species loss.
High-performance resistive random access memory using two-dimensional electron gas electrode and its switching mechanism analysis
Authors: Kim Jiho , Kwon Ohhyuk , Lee Kyumin , Han Geonhui , Hwang Hyunsang 
Published: October 2023

Abstract
In this study, a two-dimensional electron gas (2DEG), which is a conductive layer formed at the interface of Al2O3 and TiO2, was used as an electrode for resistive random access memory (RRAM) and implemented in a cell size down to 30 nm. For an RRAM device comprising W/2DEG/TiO2/W, we confirmed that the dominant switching mechanism changed from interfacial to filamentary as the cell size decreased from 500 nm to 30 nm. Through analyses of changes in forming characteristics and conduction mechanisms in the low resistive state depending on the cell size, it was identified that the 2DEG acted as an oxygen-scavenging layer of TiO2 during the resistive switching process. By comparing the switching characteristics of RRAM devices with and without 2DEG for a 30 nm cell size, we confirmed that a high-performance 2DEG RRAM was realized, with highly uniform current–voltage characteristics, a low operating voltage (∼1 V), and a high on/off ratio (>102). Finally, the applicability of the proposed device to a crossbar array was validated by evaluating 1S1R operation with an NbO2-based selector. Considering the improved switching uniformity, the 2DEG RRAM shows promise for high-density memory applications.
On variable viscosity and enhanced dissipation
Authors: Liao Xian , Zillinger Christian 
Published: October 2023

Abstract
In this article we consider the two-dimensional Navier–Stokes equations with variable viscosity depending on the vertical position. As our main result we establish linear enhanced dissipation near the non-affine stationary states replacing Couette flow. For instance, these shear flows may grow exponentially. Moreover it turns out that, in contrast to the constant viscosity case, decreasing viscosity leads to stronger enhanced dissipation and increasing viscosity leads to weaker dissipation.
Performance of LGAD strip detectors for particle counting of therapeutic proton beams
Authors: Monaco Vincenzo , Ali Omar Hammad , Bersani Davide , Abujami Mohammed , Boscardin Maurizio , Cartiglia Nicolò , Betta Gian Franco Dalla , Data Emanuele , Donetti Marco , Ferrero Marco , Ficorella Francesco , Giordanengo Simona , Villarreal Oscar Ariel Marti , Milian Felix Mas , Mohammadian-Behbahani Mohammad-Reza , Olivares Diango Montalvan , Pullia Marco , Tommasino Francesco , Verroi Enrico , Vignati Anna , Cirio Roberto , Sacchi Roberto 
Published: October 2023

Abstract

Objective. The performance of silicon detectors with moderate internal gain, named low-gain avalanche diodes (LGADs), was studied to investigate their capability to discriminate and count single beam particles at high fluxes, in view of future applications for beam characterization and on-line beam monitoring in proton therapy. Approach. Dedicated LGAD detectors with an active thickness of 55 μm and segmented in 2 mm2 strips were characterized at two Italian proton-therapy facilities, CNAO in Pavia and the Proton Therapy Center of Trento, with proton beams provided by a synchrotron and a cyclotron, respectively. Signals from single beam particles were discriminated against a threshold and counted. The number of proton pulses for fixed energies and different particle fluxes was compared with the charge collected by a compact ionization chamber, to infer the input particle rates. Main results. The counting inefficiency due to the overlap of nearby signals was less than 1% up to particle rates in one strip of 1 MHz, corresponding to a mean fluence rate on the strip of about 5 × 107 p/(cm2·s). Count-loss correction algorithms based on the logic combination of signals from two neighboring strips allow to extend the maximum counting rate by one order of magnitude. The same algorithms give additional information on the fine time structure of the beam. Significance. The direct counting of the number of beam protons with segmented silicon detectors allows to overcome some limitations of gas detectors typically employed for beam characterization and beam monitoring in particle therapy, providing faster response times, higher sensitivity, and independence of the counts from the particle energy.