bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of immune checkpoint inhibitors following discontinuation for long‐term response or toxicity in advanced or metastatic non‐small‐cell lung cancers: A retrospective study
Authors: Vacher Laure , Bernadach Maureen , Molnar Ioana , Passildas‐Jahanmohan Judith , Dubray‐Longeras Pascale 
Published: January 2024

AbstractBackground and AimsThe treatment of metastatic non‐small‐cell lung cancer (NSCLC) has been revolutionized by the arrival of immune checkpoint inhibitors (ICI). For patients without immune related adverse events (irAEs), it is recommended to continue the treatment as long as it provides clinical benefit or until unacceptable toxicity appears. The aim of our study was to evaluate survival data among patients with advanced or metastatic NSCLC following ICI discontinuation for reasons of long‐term response or toxicity (irAEs).MethodsWe included all patients with advanced or metastatic NSCLC treated with nivolumab and pembrolizumab at the Centre Jean Perrin, Clermont‐Ferrand, France (January 1, 2016 to May 31, 2019). We focused on two groups in this study population: “Voluntary treatment discontinuation” (medical decision as a result of long‐term response and patient decision) and “Treatment discontinuation due to toxicity” (irAEs). The primary endpoint was to evaluate the postdiscontinuation outcomes of these two groups: progression‐free survival (PFS) and overall survival (OS), and rechallenge in the “voluntary discontinuation” group.ResultsThe final analysis concerned 146 patients, including 10 (7%) in the “discontinuation due to toxicity” group, 11 (8%) in the “voluntary discontinuation” group, 100 (68%) who discontinued treatment as a result of progression and 25 (17%) whose treatment was still on‐going. The median PFS in the “discontinuation due to toxicity” group was not reached, and in the “voluntary discontinuation” group (n = 11) was 37 months (p = 0.4), versus 2 months in the progression group (p < 0.001). The median OS in “discontinuation due to toxicity,” and in the “voluntary discontinuation” groups was not reached (p = 0.5), versus 10 months in the progression group (p < 0.001).ConclusionTreatment discontinuation following long‐term response to ICI treatment showed sustained response and long‐term survival after discontinuation. The incidence of irAEs was associated with better long‐term survival, even after ICI discontinuation.
Sequential therapy versus quadruple therapy for Helicobacter pylori eradication: A prospective double‐blinded randomized controlled trial
Authors: Tabesh Elham , Yadmehr Farzad , Feizi Awat , Khorvash Farzin , Sindarreh Setayesh , Hakamifard Atousa 
Published: January 2024

AbstractBackgrounds and AimsThis controlled randomized clinical trial was designed to compare effectiveness, side effects, and severity of symptoms before and after therapy between quadruple (QT) and sequential regimens (SQ) for Helicobacter Pylori (H. pylori).MethodsPatients were randomly allocated into two groups. Group A received a 14‐day QT including pantoprazole 40 mg q12 h, bismuth subcitrate 240 mg q12 h, clarithromycin 500 mg q12 h, and amoxicillin 1000 mg q12 h and group B received ST including pantoprazole 40 mg q12 h and amoxicillin 1000 mg q12 h for the initial 5 days followed by pantoprazole 40 mg q12 h, clarithromycin 500 mg q12 h and tinidazole 500 mg q12 h for the next 5 days. Adverse drug reactions and patients' compliance were assessed after finishing the treatment course and also 4 weeks after. All patients were naive, therefore ST and QT were first‐line therapies. To evaluate severity of symptoms we used Short‐Form Leeds Dyspepsia Questionnaire (SF‐LDQ) before taking the first dose of regimens, at the end of therapy, and also 4 weeks after (follow‐up).ResultsThe mean age in Group A (n = 83) was 48.55 ± 12.56 and 47.24 ± 12.78 in Group B (n = 79). No statistically significant differences were observed between the two groups regarding age, gender, endoscopic findings, and also eradication rate. The analysis demonstrated a significant decrease in SF‐LDQ score between baseline and after therapy and baseline and follow‐up in both regimen groups. Both regimens were well tolerated by the majority of patients, and there were no significant differences between the two groups in terms of adverse drug reactionsConclusionThis study showed that ST can be used as an alternative first‐line therapy to QT in patients with H. pylori infection.
Circ_0087199 depletion attenuates lipopolysaccharides‐induced human periodontal ligament cell injury through the miR‐527/TLR4 axis
Authors: Wang Jing , Huo Na , Cai Chuan , Zhang Yu , Xiao Rui 
Published: January 2024

AbstractBackgroundCircular RNAs participate in the development of periodontitis. The present work aims to reveal the role and mechanism of circ_0087199 in human periodontal ligament cell (PDLC) injury during periodontitis.MethodsPDLCs were treated with lipopolysaccharides (LPS) to establish a periodontitis cell model. Quantitative real‐time polymerase chain reaction was used to detect the expression of circ_0087199, miR‐527, toll‐like receptor 4 (TLR4). Western blot analysis assay was performed to assess protein expression. Cell viability, proliferation, apoptosis and inflammation were investigated by cell counting kit‐8, EdU assay, flow cytometry and enzyme‐linked immunosorbent assay, respectively. Oxidative stress was evaluated by malondialdehyde assay kit and superoxide dismutase activity assay kit. The interaction between miR‐527 and circ_0087199 or TLR4 was confirmed by a dual‐luciferase reporter assay.ResultsCirc_0087199 and TLR4 expression levels were significantly increased, while miR‐527 was decreased in the periodontal ligament tissues of periodontitis patients and LPS‐stimulated PDLCs when compared with controls. LPS treatment inhibited cell viability and proliferation but induced cell apoptosis, inflammation and oxidative stress, whereas these effects were attenuated after circ_0087199 knockdown. Circ_0087199 bound to miR‐527 and regulated LPS‐caused PDLC damage by targeting miR‐527. Additionally, the overexpression of TLR4, a target gene of miR‐527, rescued miR‐527 mimic‐mediated effects on LPS‐treated PDLCs. Further, the regulation of circ_0087199 toward TLR4 involved miR‐527.ConclusionCirc_0087199 knockdown attenuated LPS‐induced apoptosis, inflammation and oxidative stress of PDLCs by regulating the miR‐527/TLR4 pathway.
Efficacy, safety and the lymphocyte subsets changes of low‐dose IL‐2 in patients with systemic lupus erythematosus: A systematic review and meta‐analysis
Authors: Su Qin‐Yi , Luo Jing , Wang Xin‐Miao , Di Jing‐Kai , Cao Yi‐Xin , Zhang Sheng‐Xiao 
Published: January 2024

AbstractIntroductionExisting therapies of systemic lupus erythematosus (SLE) are efficacious only in certain patients. Developing new treatment methods is urgent. This meta‐analysis aimed to evaluate the efficacy and safety of low‐dose IL‐2 (LD‐IL‐2).MethodsAccording to published data from PubMed, Web of Science, Embase, ClinicalTrials.gov, MEDLINE, MEDLINE, Web of Knowledge, Cochrane Library, and FDA.gov, eight trials were included.ResultsAfter the LD‐IL‐2 treatment, 54.8% of patients had distinct clinical remission. The SRI‐4 response rates were 0.819 (95% confidence interval [CI]: 0.745–0.894), and the SELENA‐SLEDAI scores were significantly decreased (SMD = −2.109, 95% CI: [−3.271, −0.947], p < .001). Besides, the proportions of CD4+ T (SMD = 0.614, 95% CI: [0.250, 0.979], p = .001) and Treg cells (SMD = 1.096, 95% CI: [0.544, 1.649], p < .001) were increased dramatically after LD‐IL‐2 treatment, while there were no statistical differences in the proportions of CD8+ T cells, Th1 cells, Th2 cells, and Th17 cells (p > .05). Besides, the proportions of Th17 (SMD = 1.121, 95% CI: [0.709, 1.533], p < .001) and Treg (SMD = 0.655, 95% CI: [0.273, 1.038], p = .001) were significantly increased after receiving subcutaneously 0.5 million IU of LD‐IL‐2 treatment per day for 5 days, but there were no statistical differences in the proportions of Treg after receiving 1 million IU every other day subcutaneously of LD‐IL‐2 treatment. Injection site reaction and fever were common side effects of IL‐2, which occurred in 33.1% and 14.4% of patients. No serious adverse events were reported.ConclusionLD‐IL‐2 was promising and well‐tolerated in treating SLE, which could promote Treg's proliferation and functional recovery. Injecting 0.5 million IU of IL‐2 daily can better induce the differentiation of Treg cells and maintain immune homeostasis than injecting 1 million IU every other day.
Association of fat distribution differences in infertile women with assisted reproductive outcomes: A prospective cohort study
Authors: Song Xiao‐huan , Zhu Meng‐li , Zhang Chao , Wang Jie‐yu , Jia Yue‐di , Wang Dan‐ni 
Published: January 2024

AbstractObjectiveTo investigate the impacts of fat distribution on assisted reproductive outcomes in infertile women.MethodsThe study randomly recruited 576 infertile women who underwent assisted reproductive technology treatment at the Reproductive Medicine Center of the First Affiliated Hospital of Anhui Medical University between July and October 2022. Questionnaires and body composition measurements were administered to assess baseline information and fat distribution. The numbers of oocytes, zygotes presenting with two pronuclei (2PN), and available embryos were tracked at the end of the cycle. Multifactorial logistic regression models and restricted cubic spline (RCS) curve models were used to explore the relationships between fat distribution and reproductive outcomes while controlling for confounding factors.ResultsThe study found that the participants had a mean age of 30.82 years. The analysis showed that there was a significant difference between the amount of leg body fat mass (LBFM) and the distribution of reproductive outcomes. However, there was no significant correlation between the level of visceral fat and reproductive outcomes. After taking confounding factors into account, the multifactorial regression analysis showed that the total body fat mass and the number of oocytes (odds ratio (OR) 0.92, 95% confidence interval (CI) 0.84–0.99), 2PN (OR 0.92, 95% CI 0.84–0.99), and embryos available for transfer (OR 0.90, 95% CI 0.82–0.99) were negatively correlated. RCS modeling revealed a linear dose–response relationship between LBFM and assisted reproductive outcomes.ConclusionFat distribution varies among infertile women, and higher amounts of fat are associated with poorer assisted reproductive outcomes.
Hydrogel foam dressings with angiogenic and immunomodulatory factors from mesenchymal stem cells
Authors: Lan Ziyang , Fletcher Alan , Bender Elizabeth C. , Huang Wenbai , Suggs Laura J. , Cosgriff‐Hernandez Elizabeth 
Published: January 2024

AbstractStem cell therapy and skin substitutes address the stalled healing of chronic wounds in order to promote wound closure; however, the high cost and regulatory hurdles of these treatments limit patient access. A low‐cost method to induce bioactive healing has the potential to substantially improve patient care and prevent wound‐induced limb loss. A previous study reported that bioactive factors derived from apoptotic‐like mesenchymal stem cells (MSCs) demonstrated anti‐inflammatory and proangiogenic effects and improved ischemic muscle regeneration. In this work, these MSC‐derived bioactive factors were loaded into a hydrogel foam to harness immunomodulatory and angiogenic properties from MSC components to facilitate chronic wound healing without the high cost and translational challenges of cell therapies. After incorporation of bioactive factors, the hydrogel foam retained high absorbency, moisture retention, and target water vapor transmission rate. High loading efficiency was confirmed and release studies indicated that over 90% of loaded factors were released within 24 h. Ethylene oxide sterilization and 4‐week storage did not affect the bioactive factor release profile or physical properties of the hydrogel foam dressing. Bioactivity retention of the released factors was also confirmed for as‐sterilized, 4°C‐stored, and −20°C‐stored bioactive hydrogel foams as determined by relevant gene expression levels in treated pro‐inflammatory (M1) macrophages. These results support the use of the bioactive dressings as an off‐the‐shelf product. Overall, this work reports a new method to achieve a first‐line wound dressing with the potential to reduce persistent inflammation and promote angiogenesis in chronic wounds.
Theory‐informed school counseling: Increasing efficacy through prevention‐focused practice and outcome research
Authors: Kim Hyunhee , Molina Citlali E. , Watkinson Jennifer S. , Leigh‐Osroosh Katheryne T. , Li Dan 
Published: January 2024

AbstractSchool counselors are front‐line providers to K‐12 students in the areas of learning, mental health, and career development, based on their foundation in prevention, development, wellness, and social justice. Although school counseling remains an important role within K‐12 schools, the profession faces existential threats to its continued existence due largely to the lack of applied outcome research validating its positive impact on student development. This conceptual article has two aims: (a) to reassert the unique importance of school counselors as a prevention provider who promote wellness, development, and social justice and (b) describe how theory‐informed school counseling practice is a solution using Advocating‐Student within Environment theory as an example. Implications for scholarship, training, and practice are described.
A novel hospitalist peer observation program to improve educational and operational rounding practices
Authors: Cohen Margot E. , Linganna Ashok , Kim Joyce , Orr Andrew R. 
Published: January 2024

AbstractAcademic hospitalists must balance trainee education with operational demands to round efficiently and optimize hospital throughput. Peer observation has been shown to support educator development, however, few hospitalists have formal training to optimize both skill sets. We sought to extend and adapt peer observation programs to equally focus on education and operations‐based outcomes. During the 2‐year study period, 76 of 98 (78%) eligible faculty participated in a structured, real‐time peer observation program. Immediately after observing a peer, 42% of respondents planned to adopt an operations‐related rounding behavior. Following program completion, 77% of respondents endorsed the implementation of a new rounding behavior learned from a peer, with a third of these behaviors related to clinical operations. Ninety‐five percent of respondents endorsed at least a moderate degree of program satisfaction. High levels of engagement and sustained behavior change following program participation suggest clinical operations are an important addition to peer observation programs and faculty development initiatives.
Gallbladder remnant: A potential source for biliary stones postcholecystectomy; a case report in a child with sickle cell disease
Authors: Miri Ahmad , Abdessalam Shahab , Powers Andria M. , Quiros‐Tejeira Ruben E. , Dike Chinenye R. 
Published: January 2024

AbstractStone formation in a gallbladder remnant is a rare postcholecystectomy complication. This report describes the case of gallstones in a gallbladder remnant of an adolescent with sickle cell disease (SCD) years after laparoscopic cholecystectomy. A 15‐year‐old female with SCD presented to our gastroenterology clinic with concerns of recurrent choledocholithiasis despite cholecystectomy 2 years before presentation. About 4 months before presentation to our clinic, she was evaluated at the referring physician's emergency department for recurrent severe abdominal pain of 1 month duration. After admission to the hospital, common bile duct stones were seen on magnetic resonance cholangiopancreatography (MCRP) imaging and subsequently removed via endoscopic retrograde cholangiopancreatography (ERCP). On review of her MRCP and ERCP at our hospital, a remnant of gallbladder containing multiple stones was identified. She subsequently underwent a laparoscopic resection of the gallbladder remnant. Clinicians should consider biliary duct imaging in children with biliary colic following cholecystectomy, especially those with history of chronic hemolysis.
Fat analogue emulsions stabilized by peanut protein microgel particles: microscale and nanoscale structure and stabilization process analysis
Authors: Du Liyang , Li Shaoyang , Meng Zong 
Published: January 2024

AbstractBACKGROUNDBiopolymer‐based microgels are being regarded increasingly as promising building blocks in food applications. This study aimed to clarify the evolution process of the network for fat analogue emulsions stabilized by peanut protein isolate (PPI) microgel particles. It also investigated the interfacial structure and characteristics of emulsions (50% oil phase, w/w) stabilized by microgels under different pH conditions.RESULTSThere was an increasing interfacial adsorption capacity for PPI microgels over time (from 85.26% to the maximum of 89.78% at 24 h of storage) due to the aggregation of microgels around droplets and the development of cross‐linking microgel chains between adjacent interfaces. The increased β‐sheet content (from 35.51% to 41.12%) of adsorbed microgels indicated unfolding and the enhanced aggregation of microgels, which led to stronger droplet interaction. The network evolution observed with different microscopes clarified the transition to a self‐supporting emulsion. The uneven adsorption of large microgel aggregates at the oil–water interface promoted larger and deformed droplets, so more fat‐like medium internal phase emulsion stabilized by PPI microgel could be obtained by adjusting the microgel pH to 4.5. The interfacial membranes observed by scanning electron microscopy were thicker and coarser at pH 3.0 and 4.5 than those at pH 7.0 and 9.0. The adsorption of PPI microgel aggregates enhanced the structural strength and improved emulsion stability.CONCLUSIONThis work could form a basis for further studies relating physical properties to the design of plant protein‐based fat analogues. © 2024 Society of Chemical Industry.
Nutraceutical potential of olive pomace: insights from cell‐based and clinical studies
Authors: Monteiro Camila Sant'Anna , Adedara Isaac Adegboyega , Farombi Ebenezer Olatunde , Emanuelli Tatiana 
Published: January 2024

AbstractOlive oil production yields a substantial volume of by‐products, constituting up to 80% of the processed fruits. The olive pomace by‐product represents a residue of significant interest due to the diverse bioactive compounds identified in it. However, a thorough characterization and elucidation of the biological activities of olive pomace are imperative to redirect its application for functional food, nutraceutical, and pharmaceutical purposes both for animals and humans. In this review, we examine data from experimental models, including immortalized human vascular endothelial cells, human corneal and conjunctival epithelial cells, human colorectal adenocarcinoma cells, non‐tumorigenic human hepatoma cells, and murine macrophages alongside clinical trials. These studies aim to validate the safety, nutritional value, and pharmacological effects of olive pomace. In vitro studies suggest that biophenols extracted from olive pomace possess antioxidant, anti‐inflammatory, and antiproliferative properties that could be beneficial in mitigating cardiovascular disorders, particularly atherosclerosis, hepatosteatosis, and dry‐eye disease. Protective effects against dry‐eye disease were confirmed in a mouse model assay. Olive pomace used in the feed for fish and poultry has demonstrated the ability to enhance animals' immunity and improve nutritional quality of meat and eggs. Human clinical trials are scarce and have revealed minimal biological changes following the consumption of olive pomace‐enriched foods. However, alterations in certain biomarkers tentatively suggest cardioprotective properties. The review underscores the value of olive pomace while addressing potential drawbacks and future perspectives, with a specific focus on the need for further investigation into the animal feed and human nutritional properties of olive pomace. © 2024 Society of Chemical Industry.
Serum miRNA Combined With Transvaginal Color Doppler Ultrasound Diagnosis Clinical Research on Cervical Cancer
Authors: Wang Yan , Yang Jun , Wang Yin 
Published: January 2024

ObjectivesTo explore clinical value of miRNA‐18a, miRNA‐130a, and miRNA‐92a combined with transvaginal color Doppler ultrasound (TVCDS) in the diagnosis of cervical cancer (CC).MethodsOne hundred patients with pathologically confirmed CC (CC group), 100 patients with cervical epithelial neoplasia (disease group), and 100 patients with benign uterine lesions (control group) were selected. TVCDS was performed, and the levels of serum miRNA‐18a, miRNA‐130a, and miRNA‐92a were detected.ResultsThe systolic blood velocity of the cancer group, the disease group, and the control group decreased sequentially, while the resistance index and pulsatility index increased sequentially. The serum miR‐18a, miR‐130a, miR‐92a, and expression levels of the patients' increased sequentially. Multivariate logistic regression analysis showed that age, high‐risk human papillomavirus (HR‐HPV) infection, menopause, blood flow RI, serum miRNA‐18a, miRNA‐92a, and miRNA‐130a were the influencing factors of CC. The receiver operating characteristic curve showed that the sensitivity, specificity, accuracy, and area under curve of transvaginal Doppler ultrasound in the diagnosis of CC were 86.43%, 88.01%, 84.32%, and 0.913; serum miR‐18a were, respectively, 76.56, 81.30, 80.36, and 0.839; serum miR‐130a were 77.88%, 76.97%, 78.32%, and 0.0.864; serum miR‐92a were 71.04%, 80.39%, 80.74%, and 0.894; 90.33%, 95.14%, 91.25%, and 0.947, the area under curve of the combined detection of the 3 was greater than that of the single detection.ConclusionsSerum miRNA combined with TVCDS has the advantages of it being noninvasive, and having high sensitivity and high specificity in the diagnosis of CC.
Sparsity for Ultrafast Material Identification
Authors: Qu Yurui , Zhou Qingyi , Xiang Jin , Yu Zongfu 
Published: January 2024

AbstractMid‐infrared spectroscopy is often used to identify material. Thousands of spectral points are measured in a time‐consuming process using expensive table‐top instrument. However, material identification is a sparse problem, which in theory can be solved with just a few measurements. Here the sparsity of the problem is exploited to develop an ultra‐fast, portable, and inexpensive method to identify materials. In a single‐shot, a mid‐infrared camera can identify materials based on their spectroscopic signatures. This method does not require prior calibration, making it robust and versatile in handling a broad range of materials.