bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of a Small-Scale Vacuum Generation System and Using It as an Educational Device to Demonstrate Features of the Vacuum
Authors: Marzouk Osama A. , Jul Walid Ali Marjan Haje Rhaim , Jabri Amjad Masoud Khalfan Al , Al-ghaithi Hamed Aamir Mohammed Aamir 
Published: January 2025

Abstract

We developed a vacuum generation system composed of a reciprocating compressor (3 tons of refrigeration) with an inverted-function that is ready to be hooked flexibly to a gas-tight container to create an evacuated enclosed atmosphere, without strict limitation of the size of that container. The evacuated container (or vacuum chamber) can serve in different purposes such as educational demonstration of the vacuum properties, extraction of perfumes from herbal resources, and preserving food. We tested the device and found it can reach a vacuum level of 26 inches of mercury in an environment with an atmospheric pressure of 28.5 inches of mercury. We compared the performance of our vacuum device to a rotary-vane vacuum pump of ¼ horsepowers and found that the vacuum pump reaches a set test vacuum level of 25 inches of mercury before the compressor. We then demonstrated experimentally some features of the vacuum using the inverted compressor or the vane vacuum pump. These experiments serve some topics in physics for school students as well as two core subjects of mechanical engineering, namely fluid mechanics and thermodynamics.
Shaking table test on compacted soil to reduce liquefaction potential
Authors: Rachman Asmar Muhammad Fhathur , Harimurti Harimurti , Zaika Yulvi 
Published: January 2025

Liquefaction is a granular soil material from a solid state to a liquid an increase in pore water pressure and a decrease in its effective stress. Liquefaction can cause loss of soil bearing capacity, damaging the construction above it. A simple shaking Table using a one-way vibrating Table is the tool used in this study. The earthquake accelerations used in this study are 0,3 g and 0,5 g earthquake accelerations repair method carried out in the form of compaction. Before the shaking Table test is carried out, laboratory tests are first carried out to determine the soil classification. the soil classification used in this study is SM. The purpose of this research is to determine the time of liquefaction on variations in grain size gradation and density on sand soil liquefaction with different earthquake acceleration. Based on the test results, poorly graded soil is the fastest to deformed. In 0,3 g earthquake acceleration performed total settlement of 10 mm at 100 seconds and a groundwater level in 7 mm at 15 seconds. An acceleration of 0,5 g performed total settlement of 12 mm at 10 seconds and a groundwater level in 7 mm at 15 seconds. The poorly graded soil is improved by compaction. The compacted soil in density of 17,838 kN/m3 performed settlement of 8 mm at 105 seconds and a groundwater level in 6 mm at 40 seconds in 0,3 g earthquake acceleration. The compacted soil in density of 17,995 kN/m3 performed 8 mm at 100 seconds and groundwater level in 7 mm at 20 seconds in 0,5 g earthquake acceleration. The compacted soil in density of 18,563 kN/m3 performed settlement 6 mm at the 100th second and a groundwater level 6 mm at the 25th second in 0,5 g earthquake acceleration. Based on the research results, compaction can reduce liquefaction potential
Combustion characteristics of Biosolar B20 fuel enhanced with clove oil (syzygium aromaticum) bioadditives
Authors: Subagyo Rachmat , Tamjidillah Mastiadi , Nugraha Andy , Anggono Atma Cahyo , Sukoco Krisna Enos , Permana Arya Fatia , Andriati Maria 
Published: January 2025

This study focuses on improving the combustion characteristics of Biodiesel B20 fuel by adding clove oil (Syzygium aromaticum) as a bioadditive. The main issues addressed are improving combustion efficiency and reducing emissions, which are crucial for advancing sustainable biodiesel solutions. This study investigated the effects of varying concentrations of clove oil (1–5 ml) on key combustion parameters such as ignition delay, combustion duration, peak temperature, and emissions.
The experimental results showed that adding clove oil to Biodiesel B20 significantly reduced the ignition delay and combustion duration, indicating improved combustion efficiency. In addition, the peak temperature was higher for the fuel blend with clove oil, indicating improved thermal performance. Emission analysis revealed a decrease in harmful emissions, supporting the environmental benefits of clove oil bioadditive.
These findings are explained by the high eugenol content in clove oil, which facilitates better combustion due to its oxygenated compounds. The reduction in ignition delay and combustion duration, along with the increase in peak temperature, indicates more efficient and complete combustion.
The results showed that clove oil bioadditive can improve the performance of Biodiesel B20 by increasing combustion efficiency and reducing emissions. These features make clove oil a viable bioadditive for developing more efficient and environmentally friendly biodiesel blends. The practical use of these findings is relevant for biodiesel producers and environmental policy makers aiming to promote sustainable energy solutions. The results contribute to the optimization of biodiesel formulations, supporting the global transition to renewable energy sources
Recent Advancements in Drug Targeting for Ferroptosis as an Antitumor Therapy: Development of Novel therapeutics
Authors: Negi Reena Rawat , Singh Sanju , Gupta Neeta , Upadhyay Manish , Shrivastava Shilpi , Jain Bhawana 
Published: January 2025

Objectives:
The primary objective of this review is to provide updated mechanisms that regulate ferroptosis sensitivity in cancer cells and recent advancements in drug targeting for ferroptosis as an antitumor therapy.

Methods:
To achieve these objectives, a comprehensive literature review was conducted, ana-lyzing recent studies on ferroptosis, including its cellular, molecular, and gene-level character-istics. The review involved an evaluation of advancements in ferroptosis drug research across various medical domains, with particular attention to novel therapeutic approaches in nano-medicine, TCM, and Western medicine. The review also included an assessment of how fer-roptosis influences cancer treatment, including its role in tumor drug resistance and immuno-therapy, and provided a detailed analysis of pharmacological activators of ferroptosis.

Results:
The review highlights several key findings, like primary mechanisms that regulate cancer cell sensitivity to ferroptosis, and provides an overview of the latest advancements in ferroptosis drug research. The review reveals that ferroptosis has both beneficial and detri-mental effects on human cancer, reflecting its complex role in cancer progression and treat-ment. The review also emphasizes the dual nature of ferroptosis, noting its potential as both a tumor suppressor and an oncogenic factor. Additionally, it provides a comprehensive exami-nation of various pharmacological agents that activate ferroptosis and their potential therapeu-tic applications.

Conclusion:
In conclusion, ferroptosis represents a promising target for cancer therapy, given its distinctive characteristics and significant role in tumor biology. The review underscores the need for further research to clarify the complex roles of ferroptosis in carcinogenesis and to optimize the development of novel therapeutics targeting this form of cell death. It also high-lights current challenges and opportunities in the field, including the potential for overcoming cancer metastasis through ferroptosis modulation and the need for continued exploration of pharmacological activators to advance therapeutic strategies.
Rhabdomyolysis Following Trimethoprim-Sulfamethoxazole Therapy: A Case Report and Review of the Literature
Authors: Salem Mahjoubi Yasmine , Fatma Zgolli , Israa Dahmani , Widd Kaabi , Sarrah Kastalli , Imen Aouinti , Sihem El Aidli 
Published: January 2025

Background:
Trimethoprim-Sulfamethoxazole (TMP-SMX) is a commonly used antibiotic
for the treatment of several infections, such as urinary tract infections, respiratory infections,
and in certain cases, septic arthritis. Rhabdomyolysis (RM) is very rare and less than 20
cases have been reported, so far, in the literature, in particular in immunocompromised patients.
Here, we report a case of TMP-SMX-induced RM in an immunocompetent patient, adding to the
limited data on this association.

Case Presentation:
A 53-year-old male patient with no prior medical history presented with septic
arthritis and was initiated on TMP-SMX therapy. Within days, he developed muscle pain and
weakness with laboratory tests revealing markedly elevated Creatine Kinase (CK) levels, consistent
with rhabdomyolysis. Following the discontinuation of TMP-SMX, the patient’s CK levels
gradually decreased, and his symptoms resolved without further intervention.

Conclusion:
To our knowledge, this is the sixth reported case of TMP-SMX-associated rhabdomyolysis
in an immunocompetent patient. This case highlights the need for clinicians to consider
the potential for rhabdomyolysis in patients receiving TMP-SMX, regardless of their immune
status, and to recognize that prompt withdrawal of the drug is critical for patient recovery.
The Hemostatic Effects of a Novel Gelatin Sponge Containing Aloe Vera Nanoparticles in Rat Animal Model
Authors: Panahi Paniz , Ghavimi Mohammad Ali , Zandesh Amir , Nasiri Islam , Javaheripour Ailar , Dizaj Solmaz Maleki , Sharifi Simin 
Published: January 2025

Introduction:
Biodegradable hemostat sponges are new materials in dentistry that are
used to quickly stop blood after tooth extraction. The purpose of this study was to investigate the
hemostatic effects of a new gelatin sponge containing aloe vera nanoparticles in a rat animal model.

Methods:
For this purpose, twenty-seven adult Wistar rats were purchased. The animals were divided
into three groups test, negative control, and positive control (n=9). Rats were anesthetized
with ketamine and xylazine. A small incision was made on the femoral artery and 100 mg of the
tested hemostat was pressed on it and the coagulation time was recorded with a stopwatch. A commercial
gelatin sponge without aloe vera nanoparticles was considered as a positive control group.
In the negative control group, no substance was used and the normal coagulation time was recorded.
The comparison of the mean values between the studied groups was done with the Kruskal-
Wallis test. SPSS Statistics 25.0 software was used for data analysis with a p-value less than a predetermined
significance level (0.05).

Results:
The new hemostat sponge had a faster blood clotting time than both positive and negative
control groups (P=0.04). Blood clotting time was 17.6 ± 1.0 s for the test group, 210 ± 0.86 s for
the negative control group, and 20 ± 1.2 s for the positive control group.

Conclusion:
The new gelatin sponge containing aloe vera nanoparticles can be used to control
bleeding during surgery or tooth extraction.
Screening for Metabolic Dysfunction–Associated Steatotic Liver Disease–Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study
Authors: Caussy Cyrielle , Vergès Bruno , Leleu Damien , Duvillard Laurence , Subtil Fabien , Abichou-Klich Amna , Hervieu Valérie , Milot Laurent , Ségrestin Bérénice , Bin Sylvie , Rouland Alexia , Delaunay Dominique , Morcel Pierre , Hadjadj Samy , Primot Claire , Petit Jean-Michel , Charrière Sybil , Moulin Philippe , Levrero Massimo , Cariou Bertrand , Disse Emmanuel 
Published: January 2025

OBJECTIVE
Screening for advanced fibrosis (AF) resulting from metabolic dysfunction–associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed to compare the performance of noninvasive tests (NITs) with that of two-step algorithms for detecting patients at high risk of AF requiring referral to hepatologists.

RESEARCH DESIGN AND METHODS
We conducted a planned interim analysis of a prospective multicenter study including participants with type 2 diabetes and/or obesity and MASLD with comprehensive liver assessment comprising blood-based NITs, vibration-controlled transient elastography (VCTE), and two-dimensional shear-wave elastography (2D-SWE). AF risk stratification was determined by a composite criterion of liver biopsy, magnetic resonance elastography, or VCTE ≥12 kPa depending on availability.

RESULTS
Of 654 patients (87% with type 2 diabetes, 56% male, 74% with obesity), 17.6% had an intermediate/high risk of AF, and 9.3% had a high risk of AF. The area under the empirical receiver operating characteristic curves of NITs for detection of high risk of AF were as follows: Fibrosis-4 (FIB-4) score, 0.78 (95% CI 0.72–0.84); FibroMeter, 0.74 (0.66–0.83); Fibrotest, 0.78 (0.72–0.85); Enhanced Liver Fibrosis (ELF) test, 0.82 (0.76–0.87); and SWE, 0.84 (0.78–0.89). Algorithms with FIB-4 score/VCTE showed good diagnostic performance for referral of patients at intermediate/high risk of AF to specialized care in hepatology. An alternative FIB-4 score/ELF test strategy showed a high negative predictive value (NPV; 88–89%) and a lower positive predictive value (PPV; 39–46%) at a threshold of 9.8. The FIB-4 score/2D-SWE strategy had an NPV of 91% and a PPV of 58–62%. The age-adapted FIB-4 score threshold resulted in lower NPVs and PPVs in all algorithms.

CONCLUSIONS
The FIB-4 score/VCTE algorithm showed excellent diagnostic performance, demonstrating its applicability for routine screening in diabetology. The ELF test using an adapted low threshold at 9.8 may be used as an alternative to VCTE.
Higher Order Thinking Skills in Mathematics with Project Based Learning
Authors: Ndiung Sabina , Merlin Atika Street  , Mariana Jediut  
Published: January 2025

This research was conducted to overcome teachers' problems in integrating learning activities oriented towards higher level thinking which until now has not been a priority. This research aims to analyze creative thinking skills and mathematical problem solving abilities through the application of a project-based learning model. This research uses a quantitative approach with a quasi-experiment method with posttest-only group design. The sample consisted of 53 grade V elementary school students consisting of two classes with details of the experimental class totaling 27 people and the control class totaling 26 people using random sampling techniques. Data collection techniques use test techniques. The tests used are descriptive tests both to measure creative thinking skills and for data about problem solving abilities. Based on the reliability test results, all items are in the high category. The data analysis technique uses MANOVA with the help of SPSS 23.00. Research findings show that both separately and simultaneously the creative thinking abilities and problem solving abilities of students who receive learning using the project-based learning model are higher than students who receive learning using the conventional model. Implications of this research shows that project-based learning (PBL) can improve students' abilities in critical, creative, analytical thinking and complex problem solving.
SWOT Analysis in Developing Dairy Farming Agribusiness Strategy (Case Study of "KPSBU" Lembang West Bandung Regency)
Authors: Abdullah Edi , Ambar Abdul Azis , Toaha Sahabuddin 
Published: January 2025

Livestock has a strategic role in supporting food security and economic development in Indonesia. West Bandung Regency is one of the interesting locations to study in the context of developing an agribusiness system. Despite its great potential, there are challenges in livestock development such as limited market access, the lack of distribution networks, lack of knowledge about market needs and preferences, and obstacles in complying with applicable quality standards and regulations, then the lack of supporting infrastructure and climate change. This study aims to determine the sub-district area that can be used as the basis for the development strategy of the dairy farming agribusiness system with specific contributions to the development of productivity, product diversification, farmer skills and the development of supporting infrastructure. The forms of research used are quantitative and qualitative that complement each other in a mixed approach to collect extensive data on the results of the research, conduct interviews to explore specific findings and validate the findings in the context of a deeper understanding of the data found. The sample used was 10 farmers with a purposive sampling technique. Data was collected from May to July 2024. The data collected is analyzed and if necessary validated with participants to ensure its accuracy and relevance. Data collection techniques are carried out using LQ analysis techniques, EFE and IFE analysis and SWOT analysis to produce concrete strategic solutions. The instruments in this study use an interview, observation and questionnaire system to facilitate data processing. The results showed that the total score of the weight of internal and external factors was located in the position of quadrant I (2,464 ; 2,696). If the position of the quadrant is in quadrant 1, the strategy is an aggressive growth strategy. This is very advantageous because it has strengths and opportunities. Keywords: Agribusiness, IE Matrix, LQ, SWOT
Struktur, Perilaku dan Kinerja Pasar Beras di Kabupaten Sambas
Authors: Sari Dian , Wilujeng Wilis Widi , Novita Uray Dian 
Published: January 2025

The purpose of this study was to identify marketing channels, analyze the structure, behavior and market performance of each rice marketing channel in Sambas Regency. This research was conducted in Sambas Regency which was purposively determined with the consideration that Sambas Regency is the largest rice producer in West Kalimantan. The research was conducted in Sambas Regency. Farmer respondents used were 50 farmers, Determination of the sample of traders and marketing institutions involved was done by snowball sampling method by following the flow of information from respondent farmers. Data analysis used in this study was quantitative descriptive analysis. The results of the research show that the market structure at the farm level tends to approach a perfectly competitive market structure. The market structure at the milling level tends towards oligopsony. Large traders tend to be oligopsony towards farmers. The market structure at the retailer level tends to approach a perfectly competitive market for farmers. Rice market behavior can be seen in the sales and purchase activities where traders negotiate with farmers. The payment system is generally done in cash and a small portion in advance. Cooperative Relationships Successful wholesalers build long-term relationships with farmers in their region. By maintaining good relationships, collectors can get priority when farmers want to sell their crops. Market performance analysis shows that marketing channel I is the most efficient channel because it has no margin and a relatively large farmer's share.
Русско-Устьинская локальная группа старожилов Якутии: реконструкция расселения в 1930-е гг.
Authors: Филиппова В.В. 
Published: January 2025

В статье на примере Русско-Устьинской локальной группы рассматриваются поселения русских старожилов, существовавшие в 1930-е гг. На основе анализа литературных, краеведческих и архивных источников с использованием ГИС-технологий осуществлена историческая реконструкция ареала расселения русских старожилов Якутии в 1930-е гг. Выделены следующие ареалы расселения: Индигирский (от с. Буруллино до разделения реки на протоки), Русско-Устьинский, Средний и Колымский (по названиям проток). Установлено, что после укрупнения хозяйств был сужен район хозяйственной деятельности рассматриваемой локальной группы и остался лишь Русско-Устьинской ареал расселения.
The article examines the settlements of Russian old-timers that existed in the 1930s using the Russkoe-Ustye local group as an example. The novelty of the scientific study lies in the fact that for the first time a reconstruction of the settlement of this local group of Russian old-timers in the period under study has been conducted. The objective of the article is to reconstruct the settlement network of Russkoe-Ustye residents before the process of collectivization and consolidation of settlements using GIS mapping. To achieve this objective, the following tasks were set: to collect material on the former settlements of the Russkoe-Ustye nasleg of the Allaikhovsky ulus (district); to link old settlements to a modern map; to conduct a spatial analysis of the compiled settlement maps. The study was conducted using traditional general scientific and historical methods. As a result, based on the analysis of literary, local history and archival sources using GIS technologies, a historical reconstruction of the settlement of Russian old-timers of Yakutia in the 1930s was carried out.
Фонетические особенности в речи сказителей фольклора русских старожилов Якутии (на примере сказок Русского Устья)
Authors: Бердникова Т.А. , Будищева А.А. 
Published: January 2025

В статье впервые приводятся данные сравнительного анализа фонетических особенностей сказителей русскоустьинского фольклора. При передаче одного сказочного сюжета в речи диалектоносителей наблюдаются общие черты, характерные для всего говора, и различия. Несовпадения в области фонетики могут свидетельствовать об угасающих диалектных особенностях в области фонетики под влиянием как литературного языка, так и других факторов, экстралингвистических. Записи фольклорных жанров у русских старожилов Индигирки в фонетической транскрипции в 1920‒40-х годах являются ценными свидетельствами о диалекте в конкретный исторический период.
The article examines the phonetic peculiarities in the folklore of Russian Arctic old-timers living on the Indigirka River. Methods of analyzing folklore texts recorded with the preservation of dialect features allow us to analyze the characteristic phonetic features of the dialect in the past. Such studies allow us to consider the dialects of Russian old-timers of Yakutia in retrospect, which is important for preserving linguistic diversity, which in turn draws attention to the study of the culture of Russians in the Arctic region. Similar fairy tales performed by different storytellers were selected for analysis. Having identified similarities and differences in their speech, phonetic features characteristic of this Russian old-timer dialect were established. The phonetics of the dialect has both the original, maternal features of the Northern Great Russian dialect, and a number of borrowed ones, which appeared as a result of language contacts with the indigenous small-numbered peoples of the Arctic. Thus, it is possible to assume a fairly high degree of preservation of the phonetics of one of the modern Russian old-timer dialects.