bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of QL0911 in adult patients with chronic primary immune thrombocytopenia: A multicenter, randomized, double-blind, placebo-controlled, phase III trial
Authors: Zhou Hu , Han Shouqing , Jin Jie , Huang Ruibin , Guo Xinhong , Shen Xuliang , Wang Binghua , Wang Xin , Yao Hongxia , Du Xin , Huang Meijuan , Ran Xuehong , Wang Wei , Yang Tonghua , Zhang Feng , Zheng Changcheng , Zuo Xuelan , Fu Rong , Gao Da , Ge Zheng , Han Ying , Li Yujie , Kang Xiaoyan , Shi Yan , Hou Ming 
Published: December 2023

Abstract

Objective
QL0911, a recombinant human thrombopoietin mimetic peptide-Fc fusion protein, is a romiplostim (Nplate®) biosimilar used to treat primary immune thrombocytopenia (ITP). This phase III study aimed to assess the efficacy and safety of QL0911 in adult patients with chronic primary ITP over a 24-week treatment period.

Methods
We conducted a double-blind, placebo-controlled, phase III study in patients diagnosed with primary ITP for at least 12 months who had received at least one first-line ITP treatment with no response or recurrence after treatment, or who relapsed after splenectomy at 44 sites in China. Patients were randomly allocated (2:1 ratio) to QL0911 or placebo injection subcutaneously once weekly at an initial dose of 1 μg/kg for 24 weeks. The doses were adjusted to maintain the target platelet counts from 50 × 109/L to 200 × 109/L. Patients and investigators were blinded to the assignment. The primary endpoints were the proportion of patients who achieved a durable platelet response at week 24 (platelet count, ≥ 50 × 109/L during 6 of the last 8 weeks of treatment) and safety. The study was registered at ClinicalTrials.gov (NCT05621330).

Results
Between October 2019 and December 2021, 216 patients were randomly assigned (QL0911,144; placebo,72). A durable platelet response was achieved by significantly more patients in the QL0911 group (61.8%, 95% CI: 53.3-69.8; P < 0.0001) than in the placebo group (0%). The mean duration of platelet responses was 15.9 (SE: 0.43) weeks with QL0911, and 1.9 (SE:0.26) week with placebo. Consistent results were achieved in subgroup analyses categorized by baseline splenectomy status (yes/no), concomitant ITP treatment (yes/no), and baseline platelet count (≤ 10 × 109/L, > 10 × 109/L, ≤ 20 × 109/L, > 20 × 109/L, and < 30 × 109/L). The incidence of TEAEs was comparable between the QL0911 and the placebo groups (91.7% and 88.9%, respectively). The most common adverse events overall were ecchymosis (28.5% for QL0911 vs. 37.5% for placebo), upper respiratory tract infections respiratory tract infections (31.9% for QL0911 vs. 27.8% for placebo), and gingival bleeding (17.4% for QL0911 vs. 26.4% for placebo).

Conclusion
QL0911 was well-tolerated and increased and maintained platelet counts in adults with ITP. QL0911, a biosimilar to romiplostim (Nplate®), may be a novel treatment option for patients with ITP who have failed or relapsed from first-line treatment in China. Ongoing studies will provide further data on long-term efficacy and safety in such patient populations.
Design and Performance of an Electrowetting Ionic Liquid Electrospray Thruster Prototype
Authors: Sun Wei , Guo Yuntao , Wu Zhiwen , Du Zening , Wang Ningfei , Sun Zhenning 
Published: December 2023

Porous ionic liquid electrospray thrusters are capable of meeting the propulsion requirements of micro- and nanosatellites. The liquid propellant of such a thruster is usually prefilled in the porous reservoir and emitter, then passively and uncontrollably supplied to the emitter tip, which may cause excessive propellant to submerge the emitter, thereby resulting in a short circuit of the thruster. To solve the aforementioned problems, an electrowetting ionic liquid electrospray thruster prototype is developed in this study. Electrowetting is an active control technology that can supply propellant on demand from the propellant tank to the emitter. The feasibility of electrowetting the emitter and the performance of the prototype are tested in a vacuum chamber. The results show that the porous reservoir is completely wetted by the propellant within 410 s after the electrowetting process is initiated. The prototype can work stably in the voltage range of [Formula: see text] to [Formula: see text], with a transmission efficiency of greater than 95%. The maximum specific impulse and thrust of this prototype are 5025 s and [Formula: see text], respectively, which are similar to the performance characteristics of passively fed prototypes. This study is of great significance for improving the controllability and robustness of ionic liquid electrospray thrusters.
Sexuality in Abubakar Adam Ibrahim’s Season of Crimson Blossoms
Authors: Adeleke Israel Oluwaseun 
Published: December 2023

Sexuality is a topical preoccupation in literature whether queer, perverse or conventional. In some societies, sexuality is a pious topic that hardly receives literary and critical attention. Abubakar Adam Ibrahim’s Season of Crimson Blossoms narrativises sexuality in a strict Islamic society and focalises the sexual interplay between Binta and Reza. This article examines the sexuality in the novel through Sigmund Freud’s psychoanalytic theory. Freud proposes that suppressed desires, an unresolved Oedipus complex, and past traumas impact people’s current behaviour. I contend that repressed wishes and the traumas of lingering parent-child conflicts stimulate the eros between Binta and Reza in the narrative and that Ibrahim’s subtle patriarchal ideology underlies the outcome of their sexuality. The memory and trauma of parent-child schisms experienced by Binta and Reza transmute to fetishism that leads to psychic transference, which collapses desired filial personalities into symbolic sexual figures. I conceive this conflation as symbolically incestuous and interrogate the novel’s conscious and unconscious layers by appropriating Freud’s topographical taxonomy of the psyche as a metaphor. The unconscious symptomises the patriarchal ideology that undercuts the conscious female sexual desires depicted, and this latently sustains established cultural precepts that repress emancipatory sexuality.
Selective Gamma-Ray Ionisation of Vanadium Oxides: Towards the Formation of VO2
Authors: Ndiaye M. , Sakh O. , Seck A. , Ngom B. D. , Maaza M. , Chaker M. 
Published: December 2023

In this study, we report on the valence control of vanadium oxidation states towards stabilising VO2 thin films. X-ray diffraction measurements indicate that up to 300 kGy of gamma-ray radiation the VO2 phase remains monoclinic, with the crystallite size only varying slightly with the dose. X-ray photoemission spectroscopy indicates the presence of three oxide phases (VO2, V2O3 and V2O5) on the samples. A decrease in the oxidation states of V3+ and V5+ and an increase in the valence state V4+ are observed for irradiations up to 300 kGy, which favours the vanadium dioxide VO2 formation.
Implicações clínicas do uso de Inibidores de SGLT2 no manejo da insuficiência cardíaca
Authors: Benedito Renan de Almeida , Moraes Thiago Rocha Pereira de , Murari Mariana Carvalho , Amorim Larissa Pereira , Souza Sophia Lorenzato de , Simone Maria Rosa Ramos , Batista Guilherme Matheus , Viana Clara Freire , Hora Giovanna Carvalho Estefane da , Silveira Amanda Carolina Zicatti da 
Published: December 2023

Objetivo: Avaliar as implicações clínicas do uso de inibidores de SGLT2 no manejo da insuficiência cardíaca. Métodos: Por meio da plataforma de base de dados PubMed, foi realizada uma Revisão Integrativa, com o intento de localizar fontes relevantes para tal. A pesquisa foi realizada sob o uso dos termos MeSH "Sodium-Glucose Transporter 2 Inhibitors", "Heart Failure", em associação com o uso do termo booleano “AND” para fazer a busca dos artigos, resultando em 985 artigos iniciais. Dentro desses números, devido aos critérios de inclusão e exclusão, apenas 21 foram selecionados para análise. Resultados: O uso dos fármacos inibidores SGLT2, dispõem de um alto nível de segurança e tolerabilidade em pacientes com IC e mostrou prevenir as deteriorações clínicas inerentes ao quadro clínico de um paciente com IC, bem como promover a melhora dos resultados cardiovasculares independente do estado de diabetes, reduzir a morte por todas as causas, reduzir a primeira internação por IC, bem como os desfechos renais adversos. Considerações finais: os inibidores de SGLT2 são benéficos em pacientes com insuficiência cardíaca e fração de ejeção reduzida, mesmo na ausência de diabetes. Por isso, são recomendados pelas diretrizes como uma terapia adicional aos tratamentos padrão para insuficiência cardíaca.
Modeling the weight moisture content of soils in Anabar tundra using ground-based research and remote sensing data of the earth
Authors: Nikiforova N. N. , Kalinicheva S. V. , Fedorov A. N. 
Published: December 2023

Presently, the climate is warming, with average annual temperatures rising every year, and the Arctic remaining one of the most vulnerable regions. This has a noticeable effect on the northern forests, which leads to the displacement of the tundra zone. Assessing the consequences of a projected increase in air temperature under climate change conditions requires spatial and instant monitoring of hard-to-reach areas. In the last few years, the use of remote sensing techniques and combinations of satellite imagery to calculate vegetation indices has generated great interest in obtaining high-definition ground data. The article presents the results of modeling soil moisture in Anabar tundra, which is located in the north-west of Yakutia. The study was conducted on the border of tundra and forest tundra in three reference areas (tundra, tundra young forest, tundra indigenous forest). The simulation is presented by comparing the field data and the normalized difference index of humidity NDMI. The NDMI index uses the NIR and SWIR channels, calculates a multi-channel raster object and creates a raster image with index values from -1 to 1, which show the humidity level with a spatial resolution of 10 meters. The data showed that the value of humidity pixels according to NDMI in the tundra zone is 0.04, in the tundra young forest is 0.09 and, in the tundra, native forest is 0.15. It was found that the index data correlated with field humidity data obtained from a depth of 0.2 m. A comparison of remote sensing decryption data with field data made it possible to simulate the spatial distribution of soil moisture over the vast study area by extrapolation.
Análisis Productivo, Económico y Ambiental de un sistema integrado de producción de tipo “Vac System” en la Finca El Cielo del Municipio de Arauca
Authors: Torres Borja Luz Dary , Forero Buitrago Gonzalo Alberto 
Published: December 2023

El sistema ganadero actual de la finca el Cielo en Arauca, tiene un rendimiento actual aproximado de 4.380 kg de carne en pie/año, obteniendo una ganancia de peso de 600 gr/día. Al tener la necesidad de un flujo de caja rápido para los gastos de la finca, se hace necesario establecer medidas de manera que el terreno pueda producir la mayor cantidad de alimentos por hectárea al año posible, aprovechando los residuos de subsistemas, conociendo las cadenas tróficas, logrando así una producción sostenible de manera circular. Esta propuesta consiste en el diseño de un VAC System, el cual integra modelos agroecológicos, partiendo de un modelo de ganadería intensiva que incluye actividades en agricultura, piscicultura, apicultura y lombricultura, a fin de optimizar su productividad y rentabilidad. A partir del análisis de datos históricos de producción en la finca y especificaciones técnicas propuestos orientados por los conocimientos de producción en el terreno de estudio, se analizó la disponibilidad de alimento producida por hectárea/año y la disponibilidad de biomasa entre alimento y residuos en el sistema productivo de ganadería extensiva actual, datos que se trasladaron de acuerdo a la experiencia en otros países del rendimiento de los VAC Systems en términos de kilogramos de alimento por hectárea/año.
Se seleccionó el modelo óptimo para la finca a partir de la evaluación de una matriz de criterios, valorando los aspectos ecológicos, sociales y económicos de cada alternativa. Por último, se realizó evaluación financiera tanto para el sistema de ganadería intensivo, como para el sistema integrado de producción Vac System que permite demostrar el aumento de la rentabilidad con base a indicadores financieros de rentabilidad (VAN – TIR).
El resultado que se obtuvo después de la selección del VAC System a implementar en el área de estudio, el cambio en el rendimiento es 115.75 veces mayor que el sistema productivo actual, 50.262 kg/ha/año más en alimento.
Al comparar el sistema de ganadería intensivo y VAC System a implementar, el cambio en el rendimiento es de 1,035 tn (1.035 kg) por hectárea al año más que en el sistema productivo ganadero; 0,9 tn/ha/año (900 kg) más en alimento y 0,135 tn/ha/año (135 Kg) más en biomasa de residuos sólidos. En este sentido, el Vac System logra optimizar la producción y por tanto la rentabilidad de la finca, pasando de una tasa interna de retorno del 26% al 38%.
Al implementar y conocer las variables del sistema VAC que es una fase posterior de implementación, se busca perfeccionar y optimizar el sistema para hacerlo replicable, cuyo objetivo es la búsqueda de optimizar la producción de alimentos por hectárea al año de manera sostenible con el ambiente, mejorar el flujo de caja de la unidad productiva y mejorar el precio de los alimentos al requerir menos insumos externos necesarios para la producción.
Pengembangan Game Edukasi Berbasis Macromedia Flash untuk Meningkatkan Kemampuan Belajar Bahasa Indonesia
Authors: Susanti Elvi , Nurhamidah Didah 
Published: December 2023

Penggunaan <em>Game</em> Edukasi menjad hal yang menarik untuk diterapkan di sekolah karena memberikan dampak yang positif dalam dunia pendidikan. Penelitian ini bertujuan untuk mengembangkan dan menghasilkan <em>game</em> edukasi berbasis <em>software macromedia flash</em> untuk membantu siswa SMP di Tangsel dan Jakarta dalam meningkatkan kemampuan belajar bahasa Indonesia. Game edukasi ini bisa menjadi valid dan efektif, serta dapat diterapkan sebagai media pembelajaran Bahasa Indonesia, karena menciptakan situasi belajar yang menyenangkan, memberi pemahaman materi lebih mudah, dan menambah pengalaman belajar siswa, serta memerlukan waktu yang tidak panjang bagi guru dalam menyampaikan materi. Jenis penelitian ini yaitu Research and Development (R&amp;D) yang mengacu pada model ADDIE terdiri dari <em>analysis, design, development, implementation,</em> dan <em>evaluation</em>. Hasil penelitian ini menunjukkan bahwa (1) kevalidan <em>game</em> edukasi berbasis <em>software macromedia flash</em> berdasarkan ahli materi dan ahli media mendapatkan rata-rata persentase sebesar 95% dengan kriteria “sangat valid” (2) keefektifan <em>game</em> edukasi berbasis <em>software macromedia flash</em> berdasarkan respon siswa mendapatkan persentase 94,8% yang termasuk kriteria “sangat praktis”.
A Decision Model to Support the Selection of SENKOM Personnel Using the Profile Matching Method with the Capability of Cyber Security
Authors: Semadi I Nyoman Oka , Kristomo Domy , Purnomosidi Bambang 
Published: December 2023

The very rapid development of information technology has brought tactical and strategic advantages, but it can also be a potential attack from opposing parties on the information and communication systems and networks used, thus opening the way for the emergence of a new war, namely cyber warfare. Cyber attacks are a new threat to Adisutjipto Air Base, which targets vital parts that can impact the organization and make the command and control system ineffective and inefficient. One of the important elements of Adisutjipto Lanud in facing cyber attacks is the readiness of data and communication network security personnel. In the direct or conventional personnel selection process, it is not possible to see the abilities possessed by prospective data security personnel, both in terms of skills, management aspects, analytical aspects, competency weight, and so on. A decision support system can be used to assist decision-making based on existing criteria. This research is limited to only considering the selection of personnel who will become members of komlek or senkom who are responsible for data security and communications networks at Adisutjipto Air Base. In this research, the method used is the profile matching method. The concept of the profile matching method is to compare the selection using the conventional method with the decision support system method in selecting komlek/senkom personnel as cyber security personnel so that differences in competency can be identified, also called GAP (Gross Across Product). The smaller the GAP produced, the greater the weight of the value. large, this means that personnel who meet the requirements have a greater chance of someone occupying that position. The final result of this research is to obtain ranking information for each cyber security candidate based on profile matching calculations to be able to carry out tasks optimally in securing data and networks at Adisutjipto Air Base.
Variabilidade Climática de Regiões Pluviometricamente Homogêneas na Amazônia Ocidental (Climate Variability of Rainfall Homogeneous Regions in the Amazônia Ocidental)
Authors: Santos Daris Correia dos , Medeiros Raimundo Mainar , Santos Daiane Correia , Brito José Ivaldo Barbosa de 
Published: December 2023

São aplicadas técnicas multivariadas às séries de precipitação pluvial para a Amazônia Ocidental. Utilizaram-se séries de dados médios mensais de precipitação oriundas do Instituto Nacional de Meteorologia (INMET), para o período de 1970-2001. Usaram-se os métodos de Componentes Principais e Análise de Agrupamentos para determinar os padrões espacial e temporal e regiões homogêneas com relação à precipitação pluvial. Os resultados obtidos mostraram que três regiões climaticamente homogêneas podem caracterizar a distribuição da precipitação na Amazônia Ocidental, quais sejam: a identificada como região 1 que representa a parte noroeste com altos valores de precipitação associados à condensação do ar úmido trazido pelos ventos de leste da ZCIT, que são elevados quando o escoamento sobe os Andes provocando chuvas orográficas.; a identificada como região 2, observada no extremo sul da Amazônia Ocidenttal sofre influência da ZCAS e ZCIT; a região 3, que se encontra no estado de Roraima, os totais pluviométricos mensais são influenciados pela topografia e tem como principal sistema indutor e distribuição das chuvas a ZCIT.
Palavras-chave: Precipitação, Regiões Homogêneas, Agrupamento.

A B S T R A C T
Multivariate techniques are applied to the series of rainfall for the Amazônia Ocidental. We used data series average monthly rainfall derived from the Instituto Nacional de Meteorologia (INMET) for the period 1970-2001. They used the methods of Principal Component and Cluster Analysis to determine the spatial and temporal patterns and homogeneous
regions with respect to rainfall. The results showed that three climatically homogeneous regions can characterize the distribution of precipitation in the western Amazon, which are: a region identified as one that represents the northwestern part with high amounts of precipitation associated with the condensation of humid air brought by easterly winds ZCIT, which are high when the flow rises causing the Andes orographic rainfall.; identified as the region 2, observed in the extreme south of the state of Amazônia Ocidental influenced the ZCAS and ZCIT, region 3, which in the state of Roraima, monthly rainfall totals are influenced by topography and its main inducer system and the ZCIT rainfall distribution.

Keywords: Precipitation, Regions Homogeneous Grouping.
PRZEWIDYWANIE UPADŁOŚCI POLSKICH PRZEDSIĘBIORSTW – ZASTOSOWANIE ANALIZY DYSKRYMINACYJNEJ.
Authors: Kokczyński Bernard 
Published: December 2023

Celem artykułu jest prezentacja wyników wstępnych badań z zakresu modeli predykcji bankructwa oraz porównanie metod doboru zmiennych do modelu. Czy modele oparte na zmiennych eliminowanych na podstawie siły wzajemnej korelacji cechują się lepszą predykcją, niż modele ze zmiennymi dobranymi arbitralnie.
Problem bankructwa w gospodarce jest szczególnie istotny w warunkach kryzysu gospodarczego. Według raportu PIE Polskę i pozostałe gospodarki Unii Europejskiej czeka wyraźne spowolnienie w roku 2023. Liczba upadłości przedsiębiorstw w Polsce w IV kwartale 2022 roku wyniosła 112 i była o 28,7% większa niż w analogicznym okresie roku poprzedniego, według raportu GUS.
Metodą stosowaną w badaniach była analiza dyskryminacyjna. W 6 modelach wskaźniki do budowy funkcji dyskryminacyjnej zostały dobrane za pomocą eliminacji najbardziej skorelowanych zmiennych. W 4 modelach wskaźniki zostały wybrane arbitralnie.
W wyniku przeprowadzonych badań ustalono, że metody statystyczne doboru zmiennych do modeli, są skuteczniejsze od arbitralnego wyboru zmiennych. Najlepszą predykcją cechowały się modele oparte na danych na rok przed bankructwem. W próbie testowej modele prawidłowo sklasyfikowały 62,5% niebankrutów i 87,5% bankrutów. Ponadto dokonano analizy porównawczej błędnie zaklasyfikowanych podmiotów przez modele. Ustalono, że modele błędnie klasyfikowały te same przedsiębiorstwa. Może to świadczyć o nietypowych przypadkach, które przy niewielkiej bazie danych mają wysoki udział procentowy w błędach klasyfikacji.
ANALISIS HUKUM EKONOMI SYARIAH TERHADAP KEHALALAN PRODUK MAKANAN ONLINE TANPA SERTIFIKAT HALAL MUI
Authors: Rais Amin , Maimun Maimun , Zaelani Abdul Qodir , Faizal Liky 
Published: December 2023

This article aims to explain the results of the author's analysis of the implementation of halal certificates on food products sold online, inhibiting and supporting factors for the application of halal certificates to food sold online, and the impact of Sharia economic law on the haleness of food products sold online without halal certificates. The results of the 2021 survey on e-commerce statistics show that the types of goods and services sold the most online in Lampung are food and beverage groups, totaling 40.86 percent of all businesses sampled by e-commerce. The rapid progress of buying and selling food online has become an additional task for halal certificate implementation agencies in providing security and comfort, especially for Muslim consumers in Indonesia, so they can consume halal food that is traded online. The research methodology that the author uses is qualitative in terms of the type of research documentation, interviews, and observations. The author goes directly to the field to conduct observations and interviews with primary data derived from the results of interviews with the BPJPH task force and LPPOM MUI. The results of the study show that there are no special strategies for food sold online. Supporting factors include the existence of institutions assisting the halal product process for MSME business actors. The inhibiting factor is that there is no direct regulation of cooperation with online business application server managers, a lack of public understanding of halal certificates, Analysis of Sharia Economic Law on the haleness of food products sold online: the haleness of products sold online or offline without MUI halal certificates are categorized as syubhat. According to Imam Nawawi, doing syubhat is form of underestimating.the.law.without.realizing.that.they.have.done.haram.