bluuebunny/crossref_metadata_2025_split huggingface dataset:
U-Pb zircon dates from North American and British Avalonia bracket the Lower–Middle Cambrian boundary interval, with evaluation of the Miaolingian Series as a global unit
Authors: Landing Ed , Schmitz Mark D. , Westrop Stephen R. , Geyer Gerd 
Published: December 2023

AbstractHigh-precision U-Pb zircon ages on SE Newfoundland tuffs now bracket the Avalonian Lower–Middle Cambrian boundary. Upper Lower Cambrian Brigus Formation tuffs yield depositional ages of 507.91 ± 0.07 Ma (Callavia broeggeriZone) and 507.67 ± 0.08 Ma and 507.21 ± 0.13 Ma (Morocconus-Condylopyge eliAssemblage interval). Lower Middle Cambrian Chamberlain’s Brook Formation tuffs have depositional ages of 506.34 ± 0.21 Ma (Kiskinella cristataZone) and 506.25 ± 0.07 Ma (Eccaparadoxides bennettiZone). The composite unconformity separating the Brigus and Chamberlain’s Brook formations is constrained between these ages. An Avalonian Lower–Middle Cambrian boundary between 507.2 ± 0.1 and 506.3 ± 0.2 Ma is consistent with maximum depositional age constraints from southwest Laurentia, which indicate an age for the base of the Miaolingian Series, as locally interpreted, of ≤ 506.6 ± 0.3 Ma. The Miaolingian Series’ base is interpreted as correlative within ≤ 0.3 ± 0.3 Ma between Cambrian palaeocontinents, although its exact synchrony is questionable due to taxonomic problems with a possibleOryctocephalus indicus-plexus, invariable dysoxic lithofacies control ofO. indicusand diachronous occurrence ofO. indicusin temporally distinct δ13C chemozones in South China and SW Laurentia. The lowest occurrence ofO. indicusassemblages is linked to onlap (epeirogenic or eustatic) of dysoxic facies. A united Avalonia is shown by late Early Cambrian volcanics in SW New Brunswick; Cape Breton Island; SE Newfoundland; and the Wrekin area, England. The new U-Pb ages revise Avalonian geological evolution as they show rapid epeirogenic changes through depositional sequences 4a–6.
Income or educational attainment: which is more effective in the fight against overweight? Evidence from Spain and Andalusia
Authors: Guarnido-Rueda Almudena , Amate-Fortes Ignacio , Oliver-Márquez Francisco J. , Martínez-Navarro Diego 
Published: December 2023

AbstractConsidered the epidemic of the 21st century by the WHO, obesity is a global problem that is on the rise and will continue to increase in the coming years. Spain and Andalusia, in particular, are no exception to this pathology, which has tripled since the 1970s, representing a public health challenge. The aim of this study is to analyse the socioeconomic determinants of this pathology, with special emphasis on answering the question of what has a greater influence on overweight, education level, or income. For this purpose, we have used the European Survey of Health in Spain (ESHS-2020), a microdata base, with a total of 22,072 valid individual observations (of which 2,820 belong to the Andalusian population). Results we obtain in our estimations of qualitative response models reveal that, although both income and educational attainment could be effective in the fight against overweight, the social gradient of this health problem is greater with respect to educational attainment. Additionally, there are many other variables and other factors related to the individual’s overweight (mental health, subjective state of health, oral health, among others) which are much less explored and which must be considered in health policies to combat this disease.
Polygenic risk for schizophrenia predicting social trajectories in a general population sample
Authors: Saarinen Aino , Hietala Jarmo , Lyytikäinen Leo-Pekka , Hamal Mishra Binisha , Sormunen Elina , Lavonius Veikka , Kähönen Mika , Raitakari Olli , Lehtimäki Terho , Keltikangas-Järvinen Liisa 
Published: December 2023

AbstractBackgroundWe investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRSSCZ-specific or evident also for any polygenic risk for mental disorders, e.g. for major depression.MethodsParticipants came from the population-based Young Finns Study (n = 2377). We calculated a polygenic risk score for schizophrenia (PRSSCZ) and for major depression (PRSDEP). Diagnoses of psychotic disorders were derived from the hospital care register. Social development from adolescence to middle age was measured by (a) perceived social support from friends, family, and a close other, (b) perceived sociability, and (c) family structure (partnership status, number of children, age of first-time parenthood).ResultsAmong those without manifest psychoses, high PRSSCZ predicted lower experienced support from friends (B = −0.04, p = 0.009–0.035) and family (B = −0.04, p = 0.009–0.035) especially after early adulthood, and also lower perceived sociability (B = −0.05, p = 0.010–0.026). PRSSCZ was not related to family structure. PRSDEP did not predict any domain of social development.ConclusionsIndividuals at high PRSSCZ (not converted to psychosis) seem to experience a lower preference to be with others over being alone. Individuals with high (v. low) PRSSCZ seem to have a similar family structure in terms of partnership status or number of children but, nevertheless, they experience less support from their family. Among those not converted to psychosis in a typical age period, high PRSSCZ may predict a ‘later risk phase’ and reduced functional resilience when approaching middle age.
A descriptive assessment of the informed consent document used by congenital cardiac surgery centres
Authors: Hock Kristal M. , Gist Katja , Fazeli Pariya L. , Zaccagni Hayden J. , Sorabella Robert A. , Patrician Patricia A. 
Published: December 2023

AbstractBackground:Informed consent for surgery is a complex process particularly in paediatrics. Complexity increases with procedures such as CHD surgery. Regulatory agencies outline informed consent contents for surgery. We assessed and described CHD surgical informed consent contents through survey dissemination to paediatric CHD centres across United States of America.Methods:Publicly available email addresses for 125 paediatric cardiac clinicians at 70 CHD surgical centres were obtained. Nine-item de-identified survey assessing adherence to The Joint Commission informed consent standards was created and distributed via RedCap® 14 March, 2023. A follow-up email was sent 29 March, 2023. Survey link was closed 18 April, 2023.Results:Thirty-seven surveys were completed. Results showed informed consent documents were available in both paper (25, 68%) and electronic (3, 8%) format. When both (9, 24%) formats were available, decision on which format to use was based on centre protocols (1, 11%), clinician personal preference (3, 33%), procedure being performed (1, 11%), or other (4, 45%). Five (13%) centres’ informed consent documents were available only in English, with 32 (87%) centres also having a Spanish version. Review of informed consent documents demonstrated missing The Joint Commission elements including procedure specific risks, benefits, treatment alternatives, and expected outcomes.Conclusions:Informed consent for CHD surgery is a complex process with multiple factors involved. Majority of paediatric CHD surgical centres in the United States of America used a generic informed consent document which did not uniformly contain The Joint Commission specified information nor reflect time spent in discussion with families. Further research is needed on parental comprehension during the informed consent process.
Using latent variable analysis to capture individual differences in bilingual language experience
Authors: Navarro Ester , Rossi Eleonora 
Published: December 2023

AbstractBilingualism is an experience that varies across a continuum and can change across the lifespan. Psychometric research is an underexplored avenue with the potential to further our understanding of the mechanisms and traits underlying bilingual experiences. Here, we developed and validated a social network questionnaire to measure sociolinguistic features in 212 individuals via personal social network. Confirmatory factor analysis examined the measurement structure of the variables. Compared to a one-factor model, the best fitting model was a two-factor model in which the language experience of the individual (i.e., ego) and the language experience of the individual's network (i.e., alters) were correlated latent factors under which aspects of the bilingual experience loaded. Additional analyses revealed other potential ways to examine the data in future analyses. These results provide the first measurement model of bilingual experiences, and provide support for theoretical accounts suggesting differential neuropsychological outcomes based on individual bilingual variability. The results also support the use of social network tools to capture differences in bilingualism.
Reduction of anxiety symptoms among women within a collaborative care model and women’s health settings
Authors: Standeven Lindsay R. , Miller Kristen N. , Mallow Alissa , Berger Roni , Little Virna 
Published: December 2023

Abstract

Aim:
The purpose of this study is to focus on changes in anxiety symptoms among women treated in women’s health practices and under a collaborative care model.

Background:
Research on collaborative care has largely focused on improving depressive and anxiety symptoms among adults in primary care settings. The applicability of collaborative care in other healthcare settings is underreported with limited research investigating if collaborative care has advantages in subpopulations treated in both traditional primary care settings and other healthcare settings, such as women’s health practices.

Methods:
This study, completed through secondary data analysis of the electronic record of N = 219 women across three women’s healthcare centers, evaluated if instituting a collaborative care model is associated with reduced anxiety symptoms and which factors (eg, primary diagnosis, duration of care, and use of psychotropic medications) are associated with anxiety outcomes. Anxiety symptoms were assessed using the Generalized Anxiety Disorder 7-item scale (GAD-7) at entry into and at termination from collaborative care services.

Results:
Overall, there was a significant reduction in average anxiety scores from baseline to termination of collaborative care (t(218) = 12.41, P < 0.001). There was a main effect for the duration of time receiving collaborative care services on anxiety score reduction (β = −0.28, SE = 0.06, P < 0.001) with a significant reduction in anxiety symptoms at the 90-day mark (t(218) = 10.58, P < 0.001). Therefore, collaborative care can be useful in women’s health practices in reducing anxiety symptoms over a 90-day time period.
The micro-foundations of social democratic welfare chauvinism and inclusion: class demand and policy reforms in Western Europe, 1980−2018
Authors: Harris Eloisa , Enggist Matthias 
Published: December 2023

AbstractIn Western European welfare states, research shows that support for welfare chauvinism, or the notion that welfare benefits for immigrants should be restricted, is highest among white, blue-collar working-class voters. On the other hand, higher-educated, middle-class voters are more likely to reject welfare chauvinism and support the inclusion of immigrants into the welfare state. For social democratic parties, this might pose an electoral dilemma between generous welfare states and open borders: They rely on both middle- and working-class constituencies and are ideologically tied both to a universal welfare state and the protection of (national) workers. To what extent does such an electoral dilemma between classes exist for social democratic parties? How do social democratic parties solve this dilemma when in government? In this paper, we postulate that a class divide around welfare chauvinism exists within the electorate for social democratic parties and that these parties’ policies in government reflect these divides: If the social democratic electorate has a high share of working-class voters, they should act more welfare chauvinist than if their electorate is mostly middle class. We test these hypotheses by combining survey and macro-level policy data in 14 Western European countries from 1980 to 2018. We find consistent evidence of the existence of a working-class/middle-class divide regarding welfare chauvinism, even within social democratic electorates. On the macro-level, we find partial evidence that social democratic parties in power respond to the class demands of their electorate: They are less welfare chauvinist when they have a higher proportion of middle-class voters, whereas their working-class vote share does not significantly condition their policies at all, contrary to assumptions in the literature. We therefore conclude that as social democratic parties become parties of the middle classes, the likelihood that they will retrench immigrant welfare rights reduces.
Impact of El Niño Southern Oscillation on CO2 and Solar‐Induced Fluorescence Over the Indo‐Pacific Region
Authors: Albright Ronald , Gamalathge Thishan D. K. , Wang Xinyue , Jiang Xun , Li Liming 
Published: December 2023

AbstractOver the tropical Indo‐Pacific, we explore the variations of Solar‐Induced Fluorescence (SIF), CO2, and precipitation during El Niño Southern Oscillation (ENSO) events verse other times. Based on various data sets, we analyze the time series of deseasonalized precipitation, vertical velocity, SIF, and CO2 across the Indo‐Pacific region. Our analysis reveals that there is less precipitation, more sinking air, lower SIF, and higher carbon dioxide over the Indo‐Pacific region during the El Niño events compared to other times. We also explore the spatial patterns of different variables to gain a deeper understanding of their relationships. The spatial analysis suggests that less precipitation resulting from predominant sinking air not only leads to lower SIF values by reducing photosynthetic activities but also triggers more biomass burning, which contribute to an increase in atmospheric CO2 levels across most areas of the Indo‐Pacific region. The comparative study between observational analyses and numerical simulation by the NOAA CarbonTracker model indicates that the model can simulate the increase of atmospheric column CO2 during the El Niño event, although there are some difficulties in capturing the correct spatial pattern. The results of this study can significantly enhance our understanding of the spatial‐temporal variabilities of atmospheric CO2 concentration and the observational characteristics can be used to enhance models. Furthermore, the complex interactions between ENSO and other variables revealed in this study improve our understanding of how ENSO influences the biosphere and carbon cycle.
Glacial Meltwater in the Current System of Southern Greenland
Authors: Beaird Nicholas L. , Straneo Fiamma , Le Bras Isabela , Pickart Robert , Jenkins William J. 
Published: December 2023

AbstractThe Greenland Ice Sheet is losing mass at an accelerating pace, increasing its contribution to the freshwater input into the Nordic Seas and the subpolar North Atlantic. It has been proposed that this increased freshwater may impact the Atlantic Meridional Overturning Circulation by affecting the stratification of the convective regions of the North Atlantic and Nordic Seas. Observations of the transformation and pathways of meltwater from the Greenland Ice Sheet on the continental shelf and in the gyre interior, however, are lacking. Here, we report on noble gas derived observations of submarine meltwater distribution and transports in the East and West Greenland Current Systems of southern Greenland and around Cape Farewell. In southeast Greenland, submarine meltwater is concentrated in the East Greenland Coastal Current core with maximum concentrations of 0.8%, thus significantly diluted relative to fjord observations. It is found in water with density ranges from 1,024 to 1027.2 kg m−3 and salinity from 30.6 to 34, which extends as deep as 250 m and as far offshore as 60 km on the Greenland shelf. Submarine meltwater transport on the shelf averages 5.0 ± 1.6 mSv which, if representative of the mean annual transport, represents 60%–80% of the total solid ice discharge from East Greenland and suggests relatively little offshore export of meltwater east and upstream of Cape Farewell. The location of the meltwater transport maximum shifts toward the shelfbreak around Cape Farewell, positioning the meltwater for offshore flux in regions of known cross‐shelf exchange along the West Greenland coast.
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
Authors: Enssle Julius C. , Campe Julia , Moter Alina , Voit Isabel , Gessner Alec , Yu Weijia , Wolf Sebastian , Steffen Björn , Serve Hubert , Bremm Melanie , Huenecke Sabine , Lohoff Michael , Vehreschild Maria , Rabenau Holger F. , Widera Marek , Ciesek Sandra , Oellerich Thomas , Imkeller Katharina , Rieger Michael A. , von Metzler Ivana , Ullrich Evelyn 
Published: December 2023

AbstractPatients with multiple myeloma (MM) routinely receive mRNA-based vaccines to reduce COVID-19-related mortality. However, whether disease- and therapy-related alterations in immune cells and cytokine-responsiveness contribute to the observed heterogeneous vaccination responses is unclear. Thus, we analyzed peripheral blood mononuclear cells from patients with MM during and after SARS-CoV-2 vaccination and breakthrough infection (BTI) using combined whole-transcriptome and surface proteome single-cell profiling with functional serological and T-cell validation in 58 MM patients. Our results demonstrate that vaccine-responders showed a significant overrepresentation of cytotoxic CD4+ T- and mature CD38+ NK-cells expressing FAS+/TIM3+ with a robust cytokine-responsiveness, such as type-I-interferon-, IL-12- and TNF-α-mediated signaling. Patients with MM experiencing BTI developed strong serological and cellular responses and exhibited similar cytokine-responsive immune cell patterns as vaccine-responders. This study can expand our understanding of molecular and cellular patterns associated with immunization responses and may benefit the design of improved vaccination strategies in immunocompromised patients.
Overexpressed Gαi1 exerts pro-tumorigenic activity in nasopharyngeal carcinoma
Authors: Yin De-Pei , Zhang Huanle , Teng Hua , Zhang Dan , Chen Peipei , Xie Lixiao , Liu Ji-Sheng 
Published: December 2023

AbstractThe current study tested the expression and potential functions of Gαi1 in nasopharyngeal carcinoma (NPC). The Cancer Genome Atlas (TCGA) database results demonstrate that Gαi1 transcripts’ number in NPC tissues is significantly higher than that in the normal nasal epithelial tissues. Its overexpression correlates with poor survival in certain NPC patients. Moreover, Gαi1 is significantly upregulated in NPC tissues of local primary patients and in different primary human NPC cells. Whereas its expression is relatively low in cancer-surrounding normal tissues and in primary nasal epithelial cells. Genetic silencing (via shRNA strategy) or knockout (via CRISPR-sgRNA method) of Gαi1 substantially suppressed viability, proliferation, cell cycle progression, and migration in primary NPC cells, causing significant caspase-apoptosis activation. Contrarily, ectopic Gαi1 expression exerted pro-tumorigenic activity and strengthened cell proliferation and migration in primary NPC cells. Gαi1 is important for Akt-mTOR activation in NPC cells. Akt-S6K phosphorylation was downregulated after Gαi1 shRNA or KO in primary NPC cells, but strengthened following Gαi1 overexpression. In Gαi1-silenced primary NPC cells, a S473D constitutively-active mutant Akt1 (caAkt1) restored Akt-S6K phosphorylation and ameliorated Gαi1 shRNA-induced proliferation inhibition, migration reduction and apoptosis. Bioinformatics analyses proposed zinc finger protein 384 (ZNF384) as a potential transcription factor of Gαi1. In primary NPC cells, ZNF384 shRNA or knockout (via CRISPR-sgRNA method) decreased Gαi1 mRNA and protein expression, whereas ZNF384 overexpression upregulated it. Importantly, there was an increased binding between ZNF384 protein and the Gαi1 promoter in human NPC tissues and different NPC cells. In vivo studies showed that intratumoral injection of Gαi1-shRNA-expressing adeno-associated virus (AAV) impeded subcutaneous NPC xenograft growth in nude mice. Gαi1 downregulation, Akt-mTOR inactivation, and apoptosis induction were detected in Gαi1-silenced NPC xenograft tissues. Gαi1 KO also effectively inhibited the growth of NPC xenografts in nude mice. Together, overexpressed Gαi1 exerts pro-tumorigenic activity in NPC possibly by promoting Akt-mTOR activation.
HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350
Authors: Lin Yuancai , Gong Hailong , Liu Jinliang , Hu Zhiwen , Gao Mingjun , Yu Wei , Liu Jing 
Published: December 2023

AbstractTumor suppression by inducing NCOA4-mediated ferroptosis has been shown to be feasible in a variety of tumors, including gliomas. However, the regulatory mechanism of ferroptosis induced by NCOA4 in glioma has not been studied deeply. HECW1 and ZNF350 are involved in the biological processes of many tumors, but their specific effects and mechanisms on glioma are still unclear. In this study, we found that HECW1 decreased the survival rate of glioma cells and enhanced iron accumulation, lipid peroxidation, whereas ZNF350 showed the opposite effect. Mechanistically, HECW1 directly regulated the ubiquitination and degradation of ZNF350, eliminated the transcriptional inhibition of NCOA4 by ZNF350, and ultimately activated NCOA4-mediated iron accumulation, lipid peroxidation, and ferroptosis. We demonstrate that HECW1 induces ferroptosis and highlight the value of HECW1 and ZNF350 in the prognostic evaluation of patients with glioma. We also elucidate the mechanisms underlying the HECW1/ZNF350/NCOA4 axis and its regulation of ferroptosis. Our findings enrich the understanding of ferroptosis and provide potential treatment options for glioma patients.
Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway
Authors: Wang Luoling , Deng Rilin , Chen Shuishun , Tian Renyun , Guo Mengmeng , Chen Zihao , Zhang Yingdan , Li Huiyi , Liu Qian , Tang Songqing , Zhu Haizhen 
Published: December 2023

AbstractPyroptosis, a mode of inflammatory cell death, has recently gained significant attention. However, the underlying mechanism remains poorly understood. HGS-ETR1/2 is a humanized monoclonal antibody that can bind to DR4/5 on the cell membrane and induce cell apoptosis by activating the death receptor signalling pathway. In this study, by using morphological observation, fluorescence double staining, LDH release and immunoblot detection, we confirmed for the first time that HGS-ETR1/2 can induce GSDME-mediated pyroptosis in hepatocellular carcinoma cells. Our study found that both inhibition of the AKT signalling pathway and silencing of CPA4 promote pyroptosis, while the overexpression of CPA4 inhibits it. Furthermore, we identified a positive regulatory feedback loop is formed between CPA4 and AKT phosphorylation. Specifically, CPA4 modulates AKT phosphorylation by regulating the expression of the AKT phosphatase PP2A, while inhibition of the AKT signalling pathway leads to a decreased transcription and translation levels of CPA4. Our study reveals a novel mechanism of pyroptosis induced by HGS-ETR1/2, which may provide a crucial foundation for future investigations into cancer immunotherapy.