bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis and Business Development Strategy of Mama Indri’s Shop in Kemuning Market, Loa Bakung Village
Authors: Utari Cindy , Candra Khrisna Purnawan , . Marwati 
Published: October 2023

Along with the development of the times and intense business competition, especially in the culinary field, it is very influential for small businesses such as those in traditional markets. Technological advances in this era of globalization influence the lifestyles of some people towards views about places and brand of products being marketed. There is one small business located in the Kemuning market, Loa Bakung Village named Mama Indri’s Shop which has been operating for 3 years and runs a business in the culinary field such as cake and bread. This study aims to assess business feasibility based on financial aspect as well as formulate a non-financial business development strategies. This study was analyzed using several methods of financial aspects such as the Net Present Value (NPV), Internal Rate of Return (IRR), Payback Period (PP), Benefit Cost Ratio (B/C Ratio), and analysis of non-dinancial aspects in the preparation of development strategies using the SWOT method. The result of the business feasibility analysis in this study indicate that Mama Indri’s Shop business is feasible to run with an NPV value of Rp 555,189,428 (NPV>0), IRR of 49% (IRR>the prevailing interest rate), B/C Ratio of 1.60 (B/C>1) and the value of PP/return on capital for 1 (one) Month 29 (twenty nine) Days with a business economic life of 3 years. The acquisition of appropriate non-financial analysis results is an aggressive strategy, namely being in an advantageous situation because has many strengths so that it can take advantageof opportunities in developing the business.
FREQUENCY OF SCAR DEHISCENCE IN PATIENTS WITH PREVIOUS ONE CAESAREAN SECTION HAVING SCAR TENDERNESS
Authors: Zeb Laila , Hina  
Published: October 2023

Objectives: To determine the frequency of uterine scar dehiscence in patients with previous one cesarean section having scar tenderness.
Materials and Methods: This Descriptive Cross Sectional Study was conducted in the Department of Obstetrics and Gynecology, Lady Reading Hospital, Peshawar from 28th Jan 2021 to 28th July 2021. Total 222 pregnant women with singleton pregnancy more than 28 weeks of gestation and history of previous one lower segment Caesarean Section presenting with scar tenderness were included in the study while patients having previous classical caesarean section, multiple pregnancies, not fi t for VBAC and without scar tenderness were excluded .Study was started after taking approval from IREB. Sampling was done in consecutive manner and followed to determine the occurrence of scar dehiscence.
Results: The mean age of the participants was 27.1 + 5.3 years and mean BMI was 25.2 + 2.5kg/ m2 . The mean gestational age was 38.7 +1.9 weeks. Among the participants 43.7% had parity of 1-4 and 56.3% had more than > 5. Maternal tachycardia was present in 32% and on follow up, scar dehiscence was recorded in 14.9%.
Conclusion: Scar dehiscence after previous CS is relatively common in women presenting at term pregnancy with scar tenderness. Further studies are recommended on relationship between CS, common factors which can lead to scar dehiscence and its outcome mother and new born.
PREDICTIVE ABILITY OF MANDIBULAR THIRD MOLAR IN ESTIMATION OF CHRONOLOGICAL AGE
Authors: Afsar Badshah , Afsar Rozi , Uddin Zia , Ullah Asmat , Ali Yasir 
Published: October 2023

Objective: To determine the predictive ability of mandibular third molar in estimation of chronological age
Material and methods: This is cross sectional descriptive study was conducted at Saidu college of Dentistry, Swat on 120 participants. The inclusion criteria were both males and females, age from 13 to 25 years, having good quality panoramic X-ray clearly showing lower third molar area. Participants with dental anomalies like oligodontia, Dentinogenesis/Amelogenesis imperfecta, fracture affecting angular region of mandible were excluded. Age, sex and tooth mineralization of lower third molar were recorded. Linear regression was applied using age as dependent and maturation stages of third molar as independent variable.
Results: The mean age was 16.85±2.39 years. The females were 78 (65%) and males were 42 (35%). Overall the model shows that in 79.9% participant the variation in age can be explained by maturation stages of third molar and gender. The regression equation for age estimation is age= 11.42+1.68x(maturation stage) + 0.13x(gender).
Conclusion: Mandibular third tooth maturation stages are useful in prediction of chronological age of the patients.
Preparation of Some as-Triazines, Their Evaluation as Spectrophotometric Reagents and Determination of Trace Amount of Iron in Certain Food and Natural Samples
Authors: Parvin Maksuda , Mushtari Munira , Rahman Afifa , Akter Nazmin , Islam Md Anwarul 
Published: October 2023

Spectrophotometric reagents 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine (PDT) and 3-(2-pyridyl)-5,6-bis(p-methoxyphenyl)- 1,2,4-triazine (PBMPT) were prepared from commercially available reactants simply by condensing pyridyl-2-hydrazidine with 1,2-dicarbonyl compounds. These organic reagents were used further to determine the trace amount of iron in various natural and food samples by spectrophotometric method. The absorptiometric features of iron (II) complexes of PDT and PBMPT were determined. The molar absorptivites of iron (II) complexes of PDT and PBMPT were found to be 24,181 L mol-1 cm-1 (at 556.0 nm) and 32,091 L mol-1 cm-1 at (561.8 nm) respectively. The reliability of these absorptivities were verified by standard addition technique and also by comparing the results of atomic absorption spectroscopy method. The complexes of both the reagents obey Beer’s law within the experimental concentration range 0.032mg/L - 0.159 mg/L.
Dhaka Univ. J. Sci. 71(2): 111-116, 2023 (July)
Simulation of Track and Landfall Process of Severe Cyclonic Storm Mora over the Bay of Bengal using WRF-ARW Model
Authors: Amin Akhi Most Fatema , Hossain Md Saddam , Hossain Md Shakil , Kalam Mallik Muhammad Abul 
Published: October 2023

The simulations of Severe Cyclonic Storm (SCS) Mora (28-31 May 2017) generated over the Bay of Bengal (BoB) are performed in this study to analyze its features, landfall, and track using the Weather Research and Forecasting (WRF) model. WRF-ARW model has been used on a 10 km Horizontal Resolution (HR) domain for 96, 72, 48, and 24-hour lead time simulations. The model's performance is assessed by examining Mean Sea Level Pressure (MSLP), vertical distribution of velocity components, wind flow pattern, relative vorticity, vertical wind shear, relative humidity, latent heat flux at the surface, and track pattern. The simulated results are compared carefully to the observations from the Bangladesh Meteorological Department (BMD) and the India Meteorological Department (IMD). The findings are reasonably consistent with the observations. The simulated track is also reasonable even up to 72 hours in advance. Finally, the study's results suggest that the WRF model can be used as an effective tool in predicting TCs over the BoB.
Dhaka Univ. J. Sci. 71(2): 142-152, 2023 (July)
Bridging physical and virtual ecologies of action: giving and following instructions in co-located VR-gaming sessions
Authors: Olbertz-Siitonen Margarethe , Piirainen-Marsh Arja 
Published: October 2023

Using multimodal conversation analysis, this study examines how communicative practices are adapted to the affordances for interaction in co-located encounters where participants are getting acquainted with VR-technology and games. The analysis focuses on instructional activities and investigates how an expert player guides others in learning how to handle VR equipment and getting to know the game mechanics during the initial moments of starting a new game.
The data comprises video-recordings of informal social gatherings of 3-4 young adults who take turns in trying out different VR games. The gaming situations were organized in a temporary game lab using consumer-grade VR equipment, a large screen that displayed video feed from the game console and loudspeakers for the game sound.
The analysis demonstrates how the experienced player who has no direct agency over the virtual world uses verbal and carefully placed tactile means to help novice players (who in turn have restricted access to the material world) navigate the initial stages of entering a game. Their complying actions, on the other hand, are characterized by finely tuned bodily adjustments in interplay with affordances of the technology. The instruction sequences, therefore, represent interactional moments in which the participants mutually attend to asymmetries, orienting to bridging physical and virtual ecologies of action.
PENGGUNAAN METODE TALKING STICK UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN IPA KELAS VI DI SDN MERTAK PAOK
Authors: Irfan Ahmad Zainul 
Published: October 2023

Berbagai cara dan metode dilakukan oleh guru dalam kegiatan belajar mengajar untuk menyampaikan informasi agar efektif dapat diterima oleh siswa. Namun, seefektif apapun penyampaian materi pelajaran oleh guru, tidak semuanya dapat diterima oleh siswa. Ketika pemahaman siswa dirasa masih belum maksimal, tentu seorang guru harus memikirkan cara agar siswa dapat berlatih lebih banyak tentang materi tersebut. Penelitian tindakan kelas ini dilaksanakan pada kelas VI SDN Mertak paok. Subjek penelitian berjumlah 18 siswa. Penelitian ini dilakukan sebanyak dua siklus. Tujuan dalam penelitian tindakan kelas ini adalah sebagai berikut: (1) Untuk mengetahui dan mendeskripsikan penerapan pembelajaran IPA dengan metode Talking Stick pada siswa kelas VI SDN Mertak paok. (2) Untuk mengetahui dan menjelaskan peningkatan hasil belajar siswa pada mata pelajaran IPS dengan menerapkan metode Talking Stick pada siswa kelas VI SDN Mertak paok. Metode penelitian yang digunakan adalah metode kualitatif yaitu penelitian ini akan mendiskripsikan peristiwa yang terjadi dalam bentuk kalimat, untuk melengkapi data kualitatf digunakan juga data kuantitaif yaitu untuk mengukur hasil belajar siswa yang diperoleh dari hasil tes yang diberikan pada siswa. Data kuantitaif berupa angka hasil belajar siswa, sedangkan data kualitatif merupakan ungkapan yang menunjukkan tentang proses dan hasil belajar yang diperoleh siswa. Hasil penelitian menunjukkan siswa lebih semangat dan antusias dalam mengikuti pembelajaran dengan penerapan metode Talking Stick karena menunjang keberlangsungan pembelajaran sehingga meningkatkan hasil belajar siswa pada mata pelajaran IPA (Ilmu Pengetahuan Alam). Hasil belajar yang diperoleh siswa mengalami peningkatan, dari siklus I sebesar 58% meningkat menjadi 84% pada siklus II. Penerapan metode Talking Stick diharapkan dapat digunakan kembali untuk semua jenjang kelas, karena dalam penelitian ini membuktikan adanya peningkatan hasil belajar IPA pada siswa kelas VI SDN Mertak paok.
«Locomotive syndrome» in patients in the geriatric hospital
Authors: Topolyanskaya S. V. , Romanova M. A. , Vakulenko O. N. , Bubman L. I. , Eliseeva T. A. , Larina D. S. , Ratchina S. A. , Dvoretski L. I. 
Published: October 2023

The study aim was to analyze the prevalence and course of locomotive syndrome in patients in the geriatric hospital.Materials and methods. This work was a cross-sectional study performed on the basis of the Moscow War Veterans Hospital N3. The study enrolled 58 patients – 43 women (74.1%) and 15 men (25.9%) hospitalized in the geriatric department of the hospital. The mean age of study patients was 82.7+5.9 years, varying from 75 to 96 years. A comprehensive geriatric assessment was performed, including the Age Is Not a Barrier Questionnaire, the Basic Daily Activity Scale (Bartel Index), the Instrumental Activities of Daily Living (IADL) Scale, and the Morse Falls Scale. Questionnaires were filled out to assess the locomotive syndrome – GLFS‑5 and GLFS‑25. A 2 step test was carried out.Results. In 48 out of 58 patients (82.8%), locomotive syndrome was found: in 88.4% of women and in 66.7% of men (p=0.05). Locomotive syndrome was diagnosed in all centenarians, in 82.7% of patients aged 80 to 89 years and in 75% of patients aged 75–79 years. The main cause of the locomotive syndrome was degenerative-dystrophic changes in the spine and joints observed in all patients. Only 1 patient had stage I locomotive syndrome, all the rest had stage II. Patients with locomotive syndrome had lower levels of activity in everyday life – 84.3±11.2 and 93.0±6.3 points according to the Barthel index, respectively (p=0.01), greater severity of pain syndrome according to VAS – 4.2±1.8 and 1.7±1.6 points, respectively (p=0.003) and a shorter distance of 2 steps (123.3±30.9 and 148.1±20.7 cm, respectively (p=0.003). Direct correlations were established between the values of the GLFS‑5 locomotive function scale and the age of patients (r=0.33; p=0.01), as well as the severity of chronic pain syndrome according to VAS (r=0.55; p=0.00007). Inverse relationships were registered between the indicators of the GLFS‑5 scale and the Barthel index (r= –0.44; p=0.0005), the IADL scale (r= –0.41; p=0.001) and the distance traveled in the «2 steps» test (r= –0.52; p=0.0007). Inverse correlations were observed between the values of the GLFS‑25 scale and the Barthel index (r= –0.41; p=0.008), the IADL scale (r= –0.59; p=0.00008), the Mini-COG test (r= –0.37; p=0.02), as well as indicators of bone mineral density in the proximal femur (r= –0.39; p=0.04 – r= –0.54; p=0.002). Conclusions. The study results indicate that patients in the geriatric hospital very often have locomotive syndrome associated with the pathology of the musculoskeletal system. The severity of the locomotive syndrome correlates with the indicators of the functional activity of patients, the intensity of the pain syndrome and the bone mineral density.
Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes
Authors: Li Qi , Li Xiao , Kan Shuo , Zhu Ting-Jun , Li Chang , Du Xin-Yue , Wang Xin , Yan Hui-Bo , Wu Chen-Yun , Chen Guang-Jie , Qian Men-Bao , Yan Min , Wang Zhao-Jun 
Published: October 2023

IntroductionClonorchis sinensis infection results in various complications in the liver and biliary systems and is a neglected tropical disease in Eastern Asia. In this study, we report that C. sinensis calcium-binding protein Cs16 activates host immune cells and induces immunopathology in liver.MethodsImmunohistochemistry was used to detect the localization of Cs16 in C. sinensis adult worms. ELISA was used to detect the serum levels of anti-Cs16 IgG antibody in infected humans and mice. Bile duct injection model was used to figure out the role of Cs16 in vivo. RT-qPCR and ELISA were used to detect the cytokine production from Cs16-treated BMMs in vitro. Seahorse assay was used to detect the metabolic pathway of Cs16-treated BMMs in vitro.ResultCs16 localizes in the tegument and gut of C. sinensis. Humans and mice with C. sinensis infection exhibited increased levels of anti-Cs16-specific antibody. Using the bile duct injection technique, we found that Cs16 induced obvious inflammation and hepatic necrosis in vivo. Cs16 treatment caused the upregulation of inflammatory cytokines in innate immune cells. Moreover, Cs16-treated monocytes relied more on the glycolytic metabolic pathway.DiscussionOur findings suggest that Cs16 is a potential pathogenic factor derived from C. sinensis adult worm. By reprogramming the metabolic pathway of innate immune cells, Cs16 triggers pro-inflammatory responses in the liver, and therefore, Cs16 is a potential target for the prevention and treatment of clonorchiasis.
Electrocardiographic characteristics associated with late gadolinium enhancement and prognostic value in patients with dilated cardiomyopathy
Authors: Chayanopparat Punyanuch , Boonyasirinant Thananya , Prapan Natthaporn , Phoopattana Supamongkol , Kaolawanich Yodying 
Published: October 2023

BackgroundLate gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging has emerged as an important tool for assessment of patients with dilated cardiomyopathy (DCM). Electrocardiography (ECG) is an accessible, reproducible, low-cost diagnostic and prognostic tool. This study aimed to investigate the ECG characteristics associated with LGE, as well as to assess the prognostic significance of ECG in patients with DCM.MethodsConsecutive patients diagnosed with DCM by CMR [left ventricular ejection fraction (LVEF) &lt; 50%] between 2011 and 2020 were included. Multivariable analysis was conducted to evaluate ECG predictors associated with LGE. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic performance of ECG in combination of clinical data and LVEF for LGE. Two composite outcomes were also assessed among patients with and without ECG predictors: (1) sudden cardiac death (SCD), sustained ventricular arrhythmia, or appropriate implantable cardioverter-defibrillator (ICD) therapy, and (2) all-cause death or hospitalization for heart failure.ResultsA total of 422 patients, with a mean age of 59.5 ± 16.3 years (58.3% male), were included. LGE was present in 169 (40%) of the patients. Multivariable analysis identified lateral inverted T-waves, intraventricular conduction delay, low voltage, and fragmented QRS as independent predictors of LGE. ROC analysis showed a significant increase in the area under the curve (AUC) when ECG predictors of the four aforementioned characteristics were added to the clinical-LVEF model (AUC 0.66, 95% CI 0.59–0.71 vs. 0.72, 95% CI 0.67–0.78, p = 0.003). During a median follow-up of 2.7 years (IQR 0.8, 5.2), 16 events of SCD, sustained ventricular arrhythmia, or appropriate ICD therapy, and 70 events of all-cause death or hospitalization for heart failure occurred. ECG predictors were independently associated with SCD, sustained ventricular arrhythmia, or appropriate ICD therapy (HR 4.84, 95% CI 1.34–17.40, p = 0.01). However, ECG predictors were not associated with all-cause death or hospitalization for heart failure (HR 1.22, 95% CI 0.76–1.96, p = 0.39).ConclusionIn patients with DCM, lateral inverted T-waves, intraventricular conduction delay, low voltage, and fragmented QRS were independently associated with LGE. Additionally, these ECG predictors had prognostic value for predicting SCD, sustained ventricular arrhythmia, or appropriate ICD therapy, assisting clinicians in stratifying SCD risk and identifying primary prevention ICD implantation candidates.
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis
Authors: Xiao Qing-Ao , Yang Yun-Fei , Chen Lin , Xie Ying-Chun , Li Hai-Tao , Fu Zhi-Gang , Han Qiang , Qin Jia , Tian Jie , Zhao Wen-Jiang , Cai Fei , Hu Yin-Tao , Ai Lin-Feng , Li Chao , Chen Xu-Ying , Wang Decheng , Tan Yu-Yan , Xia Xuan , Zhang Xiao-Lin 
Published: October 2023

Background and aimPrevious studies have reported an association between gut microbiota and cirrhosis. However, the causality between intestinal flora and liver cirrhosis still remains unclear. In this study, bi-directional Mendelian randomization (MR) analysis was used to ascertain the potential causal effect between gut microbes and cirrhosis.MethodsLarge-scale Genome Wide Association Study (GWAS) data of cirrhosis and gut microbes were obtained from FinnGen, Mibiogen consortium, and a GWAS meta-analysis of Alcoholic cirrhosis (ALC). Two-sample MR was performed to determine the causal relationship between gut microbiota and cirrhosis. Furthermore, a bi-directional MR analysis was employed to examine the direction of the causal relations.ResultIn MR analysis, we found that 21 gut microbiotas were potentially associated with cirrhosis. In reverse MR analysis, 11 gut microbiotas displayed potentially associations between genetic liability in the gut microbiome and cirrhosis. We found that the family Lachnospiraceae (OR: 1.59, 95% CI:1.10–2.29) might be harmful in cirrhotic conditions (ICD-10: K74). Furthermore, the genus Erysipelatoclostridium might be a protective factor for cirrhosis (OR:0.55, 95% CI:0.34–0.88) and PBC (OR:0.68, 95% CI:0.52–0.89). Combining the results from the MR analysis and reverse MR analysis, we firstly identified the Genus Butyricicoccus had a bi-directional causal effect on PBC (Forward: OR: 0.37, 95% CI:0.15–0.93; Reverse: OR: 1.03, 95% CI:1.00–1.05).ConclusionWe found a new potential causal effect between cirrhosis and intestinal flora and provided new insights into the role of gut microbiota in the pathological progression of liver cirrhosis.
Integrate prediction of machine learning for single ACoA rupture risk: a multicenter retrospective analysis
Authors: Li Yang , Huan Linchun , Lu Wenpeng , Li Jian , Wang Hongping , Wang Bangyue , Song Yunfei , Peng Chao , Wang Jiyue , Yang Xinyu , Hao Jiheng 
Published: October 2023

BackgroundStatistically, Anterior communicating aneurysm (ACoA) accounts for 30 to 35% of intracranial aneurysms. ACoA, once ruptured, will have an acute onset and cause severe neurological dysfunction and even death. Therefore, clinical analysis of risk factors related to ACoA and the establishment of prediction model are the benefits to the primary prevention of ACoA.MethodsAmong 1,436 cases of single ACoA patients, we screened 1,325 valid cases, classified risk factors of 1,124 cases in the ruptured group and 201 cases in the unruptured group, and assessed the risk factors, respectively, and predicted the risk of single ACoA rupture by using the logistic regression and the machine learning.ResultsIn the ruptured group (84.8%) of 1,124 cases and the unruptured group (15.2%) of 201 cases, the multivariable logistic regression (MLR) model shows hemorrhagic stroke history (OR 95%CI, p:0.233 (0.120–0.454),&lt;0.001) and the age stratification of 60–69 years (OR 95%CI, p:0.425 (0.271–0.668),&lt;0.001) has a significant statistic difference. In the RandomForest (RF) model, hemorrhagic stroke history and age are the best predictive factors.ConclusionWe combined the analysis of MLR, RF, and PCA models to conclude that hemorrhagic stroke history and gender affect single ACoA rupture. The RF model with web dynamic nomogram, allows for real-time personalized analysis based on different patients’ conditions, which is a tremendous advantage for the primary prevention of single ACoA rupture.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=178501.