bluuebunny/crossref_metadata_2025_split huggingface dataset:
Race and systemic crises in international politics: An agenda for pluralistic scholarship
Authors: Rosenberg Andrew S. 
Published: January 2024

AbstractIn recent years, scholars of global politics have shown that issues of race and white supremacy lie at the centre of international history, the birth of the field of International Relations, and contemporary theory. In this article, I argue that race plays an equally central role in the 21st century’s current and future crises: the set of systemic risks that includes intensifying climate change, deepening inequality, the endemic instabilities of capitalism, and migration. To make this argument, I describe the contours of the current crisis and show how racism amplifies its effects. In short, capitalism’s winners and losers and the effects of climate change fall along racial lines, amplifying both direct and indirect racial discrimination against non-white migrants and states in the Global South. These interdependent crises will shape the next 50 years of international politics and will likely perpetuate the vicious cycle of global racial inequality. Accordingly, this article presents a research agenda for all IR scholars to explore the empirical implications of race in the international system, integrate marginalised perspectives on global politics from the past and present into their scholarship, and address the most pressing political issues of the 21st century.
Phonetically incomplete neutralisation can be phonologically complete: evidence from Huai’an Mandarin
Authors: Du Naiyan , Durvasula Karthik 
Published: January 2024

AbstractThe phenomenon of incomplete neutralisation describes a situation where a putative case of categorical phonological neutralisation is observed to be phonetically non-neutralising. This has been argued to be a problem for phonological theories that employ categorical features. Here, we use two distinct feeding orders of tone sandhi processes from Huai’an Mandarin to show that incomplete phonetic neutralisation is compatible with categorical phonological phenomena. Therefore, incomplete phonetic neutralisation does not automatically inform us of gradient phonological representations. We further show that incomplete phonetic neutralisation can in fact have a large effect size. Such results are not surprising from a classic generative view of phonology where linguistic performance is argued to be a multi-factorial problem, and linguistic knowledge (i.e., competence) is only one of the many factors involved. Furthermore, our results suggest that the observed incompleteness or gradience may have a source outside phonological knowledge.
Control of Stability and Relative Humidity in the Radiative‐Convective Equilibrium Model Intercomparison Project
Authors: Wing Allison A. , Singh Martin S. 
Published: January 2024

AbstractThe Radiative‐Convective Equilibrium Model Intercomparison Project (RCEMIP) exhibits a large spread in the simulated climate across models, including in profiles of buoyancy and relative humidity. Here we use simple theory to understand the control of stability, relative humidity, and their responses to warming. Across the RCEMIP ensemble, temperature profiles are systematically cooler than a moist adiabat, and convective available potential energy (CAPE) increases with warming at a rate greater than that expected from the Clausius‐Clapeyron relation. There is higher CAPE (greater instability) in models that are on average moister in the lower‐troposphere. To more explicitly evaluate the drivers of the intermodel spread, we use simple theory to estimate values of entrainment and precipitation efficiency (PE) given the simulated values of CAPE and lower‐tropospheric relative humidity. We then decompose the intermodel spread in CAPE and relative humidity (and their responses to warming) into contributions from variability in entrainment, PE, the temperature of the convecting top, and the inverse water vapor scale height. Model‐to‐model variation in entrainment is a dominant source of intermodel spread in CAPE and its changes with warming, while variation in PE is the dominant source of intermodel spread in relative humidity. We also decompose the magnitude of the CAPE increase with warming and find that atmospheric warming itself contributes most strongly to the CAPE increase, but the indirect effect of increases in the water vapor scale height with warming also contribute to increasing CAPE beyond that expected from Clausius‐Clapeyron.
Acoustofluidic separation of prolate and spherical micro-objects
Authors: Khan Muhammad Soban , Ali Mushtaq , Lee Song Ha , Jang Keun Young , Lee Seong Jae , Park Jinsoo 
Published: January 2024

AbstractMost microfluidic separation techniques rely largely on object size as a separation marker. The ability to separate micro-objects based on their shape is crucial in various biomedical and chemical assays. Here, we develop an on-demand, label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and torque. The freely rotating non-spherical micro-objects were aligned under the progressive acoustic field by the counterrotating radiation torque, and the major axis of the prolate ellipsoids was parallel to the progressive wave propagation. The specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave propagation. As a consequence, the acoustic backscattering decreased, resulting in a decreased magnitude of the radiation force. Through the variation in radiation force, which depended on the micro-object morphology enabled the acoustofluidic shape-based separation. We conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method. A series of experiments with polystyrene microspheres, prolate ellipsoids, and peanut-shaped microparticles were performed for validation. Through quantitative analysis of the separation efficiency, we confirmed the high purity and high recovery rate of the proposed acoustofluidic shape-based separation of micro-objects. As a bioparticle, we utilize Thalassiosira eccentrica to perform shape-based separation, as the species has a variety of potential applications in drug delivery, biosensing, nanofabrication, bioencapsulation and immunoisolation.
Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans
Authors: Zimmer J. , Mueller L. , Frank-Herrmann P. , Rehnitz J. , Dietrich J. E. , Bettendorf M. , Strowitzki T. , Krivega M. 
Published: January 2024

AbstractDevelopment of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility. We used different study groups: individuals with Differences of Sex Development (DSD), including Complete Androgen Insensitivity Syndrome (CAIS) due to mutated androgen receptor (AR), and men with idiopathic nonobstructive azoospermia. Both showed genome integrity status influenced by androgen signaling via innate immune response activation in blood and gonads. Whole proteome analysis connected low AR to interleukin-specific gene expression, while compromised genome stability and tumorigenesis were also supported by interferons. AR expression was associated with predominant DNA damage phenotype, that eliminated AR-positive Sertoli cells as the degeneration of gonads increased. Low AR contributed to resistance from the inhibition of DNA repair in primary leukocytes. Downregulation of androgen promoted apoptosis and specific innate immune response with higher susceptibility in cells carrying genomic instability.
Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models
Authors: Rodriguez-Berriguete Gonzalo , Puliyadi Rathi , Machado Nicole , Barberis Alessandro , Prevo Remko , McLaughlin Martin , Buffa Francesca M. , Harrington Kevin J. , Higgins Geoff S. 
Published: January 2024

AbstractImmune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer cells. However, a substantial number of patients treated with ICB develop relapse or do not respond, which has been partly attributed to the immune-suppressive effect of tumour hypoxia. We have previously demonstrated that the mitochondrial complex III inhibitor atovaquone alleviates tumour hypoxia both in human xenografts and in cancer patients by decreasing oxygen consumption and consequently increasing oxygen availability in the tumour. Here, we show that atovaquone alleviates hypoxia and synergises with the ICB antibody anti-PD-L1, significantly improving the rates of tumour eradication in the syngeneic CT26 model of colorectal cancer. The synergistic effect between atovaquone and anti-PD-L1 relied on CD8+ T cells, resulted in the establishment of a tumour-specific memory immune response, and was not associated with any toxicity. We also tested atovaquone in combination with anti-PD-L1 in the LLC (lung) and MC38 (colorectal) cancer syngeneic models but, despite causing a considerable reduction in tumour hypoxia, atovaquone did not add any therapeutic benefit to ICB in these models. These results suggest that atovaquone has the potential to improve the outcomes of patients treated with ICB, but predictive biomarkers are required to identify individuals likely to benefit from this intervention.
Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma
Authors: Li Jingzhi , Guo Ming , Chen Lin , Chen Zhuchu , Fu Ying , Chen Yongheng 
Published: January 2024

AbstractNasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Southeast Asia, especially in South China. The pathogenesis of NPC is complex, and genetic alterations of tumor suppressors and proto-oncogenes play important roles in NPC carcinogenesis. p53 is unexpectedly highly expressed in NPC and possesses an uncommon mutation of R280T, which is different from a high frequency of hotspot mutations or low expression in other tumors. However, the mechanism of p53 loss of function and its correlation with R280T in NPC are still unclear. In this study, p53 amyloid aggregates were found to be widespread in NPC and can be mainly induced by the R280T mutation. Aggregated p53-R280T impeded its entry into the nucleus and was unable to initiate the transcription of downstream target genes, resulting in decreased NPC cell cycle arrest and apoptosis. In addition, NPC cells with p53-R280T amyloid aggregates also contributed aggressively to tumor growth in vivo. Transcriptome analysis suggested that p53 amyloid aggregation dysregulated major signaling pathways associated with the cell cycle, proliferation, apoptosis, and unfolded protein response (UPR). Further studies revealed that Hsp90, as a key molecular chaperone in p53 folding, was upregulated in NPC cells with p53-R280T aggregation, and the upregulated Hsp90 facilitated p53 aggregation in turn, forming positive feedback. Therefore, Hsp90 inhibitors could dissociate p53-R280T aggregation and restore the suppressor function of p53 in vitro and in vivo. In conclusion, our study demonstrated that p53-R280T may misfold to form aggregates with the help of Hsp90, resulting in the inability of sequestered p53 to initiate the transcription of downstream target genes. These results revealed a new mechanism for the loss of p53 function in NPC and provided novel mechanistic insight into NPC pathogenesis.
Ferric reduction by a CYBDOM protein counteracts increased iron availability in root meristems induced by phosphorus deficiency
Authors: Maniero Rodolfo A. , Picco Cristiana , Hartmann Anja , Engelberger Felipe , Gradogna Antonella , Scholz-Starke Joachim , Melzer Michael , Künze Georg , Carpaneto Armando , von Wirén Nicolaus , Giehl Ricardo F. H. 
Published: January 2024

AbstractTo mobilize sparingly available phosphorus (P) in the rhizosphere, many plant species secrete malate to release P sorbed onto (hydr)oxides of aluminum and iron (Fe). In the presence of Fe, malate can provoke Fe over-accumulation in the root apoplast, triggering a series of events that inhibit root growth. Here, we identified HYPERSENSITIVE TO LOW P1 (HYP1), a CYBDOM protein constituted of a DOMON and a cytochrome b561 domain, as critical to maintain cell elongation and meristem integrity under low P. We demonstrate that HYP1 mediates ascorbate-dependent trans-plasma membrane electron transport and can reduce ferric and cupric substrates in Xenopus laevis oocytes and in planta. HYP1 expression is up-regulated in response to P deficiency in the proximal zone of the root apical meristem. Disruption of HYP1 leads to increased Fe and callose accumulation in the root meristem and causes significant transcriptional changes in roots. We further demonstrate that HYP1 activity overcomes malate-induced Fe accumulation, thereby preventing Fe-dependent root growth arrest in response to low P. Collectively, our results uncover an ascorbate-dependent metalloreductase that is critical to protect root meristems of P-deficient plants from increased Fe availability and provide insights into the physiological function of the yet poorly characterized but ubiquitous CYBDOM proteins.
Distributed quantum sensing of multiple phases with fewer photons
Authors: Kim Dong-Hyun , Hong Seongjin , Kim Yong-Su , Kim Yosep , Lee Seung-Woo , Pooser Raphael C. , Oh Kyunghwan , Lee Su-Yong , Lee Changhyoup , Lim Hyang-Tag 
Published: January 2024

AbstractDistributed quantum metrology has drawn intense interest as it outperforms the optimal classical counterparts in estimating multiple distributed parameters. However, most schemes so far have required entangled resources consisting of photon numbers equal to or more than the parameter numbers, which is a fairly demanding requirement as the number of nodes increases. Here, we present a distributed quantum sensing scenario in which quantum-enhanced sensitivity can be achieved with fewer photons than the number of parameters. As an experimental demonstration, using a two-photon entangled state, we estimate four phases distributed 3 km away from the central node, resulting in a 2.2 dB sensitivity enhancement from the standard quantum limit. Our results show that the Heisenberg scaling can be achieved even when using fewer photons than the number of parameters. We believe our scheme will open a pathway to perform large-scale distributed quantum sensing with currently available entangled sources.
Significantly wetter or drier future conditions for one to two thirds of the world’s population
Authors: Trancoso Ralph , Syktus Jozef , Allan Richard P. , Croke Jacky , Hoegh-Guldberg Ove , Chadwick Robin 
Published: January 2024

AbstractFuture projections of precipitation are uncertain, hampering effective climate adaptation strategies globally. Our understanding of changes across multiple climate model simulations under a warmer climate is limited by this lack of coherence across models. Here, we address this challenge introducing an approach that detects agreement in drier and wetter conditions by evaluating continuous 120-year time-series with trends, across 146 Global Climate Model (GCM) runs and two elevated greenhouse gas (GHG) emissions scenarios. We show the hotspots of future drier and wetter conditions, including regions already experiencing water scarcity or excess. These patterns are projected to impact a significant portion of the global population, with approximately 3 billion people (38% of the world’s current population) affected under an intermediate emissions scenario and 5 billion people (66% of the world population) under a high emissions scenario by the century’s end (or 35-61% using projections of future population). We undertake a country- and state-level analysis quantifying the population exposed to significant changes in precipitation regimes, offering a robust framework for assessing multiple climate projections.
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners
Authors: Sharma Pankaj , Maklashina Elena , Voehler Markus , Balintova Sona , Dvorakova Sarka , Kraus Michal , Hadrava Vanova Katerina , Nahacka Zuzana , Zobalova Renata , Boukalova Stepana , Cunatova Kristyna , Mracek Tomas , Ghayee Hans K. , Pacak Karel , Rohlena Jakub , Neuzil Jiri , Cecchini Gary , Iverson T. M. 
Published: January 2024

AbstractComplex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the level of assembly, a process that leverages metastable assembly intermediates. The nature of these intermediates and how CII subunits transfer between metastable complexes remains unclear. In this work, we identify metastable species containing the SDHA subunit and its assembly factors, and we assign a preferred temporal sequence of appearance of these species during CII assembly. Structures of two species show that the assembly factors undergo disordered-to-ordered transitions without the appearance of significant secondary structure. The findings identify that intrinsically disordered regions are critical in regulating CII assembly, an observation that has implications for the control of assembly in other biomolecular complexes.
Methane-hydrogen-rich fluid migration may trigger seismic failure in subduction zones at forearc depths
Authors: Giuntoli Francesco , Menegon Luca , Siron Guillaume , Cognigni Flavio , Leroux Hugues , Compagnoni Roberto , Rossi Marco , Vitale Brovarone Alberto 
Published: January 2024

AbstractMetamorphic fluids, faults, and shear zones are carriers of carbon from the deep Earth to shallower reservoirs. Some of these fluids are reduced and transport energy sources, like H2and light hydrocarbons. Mechanisms and pathways capable of transporting these deep energy sources towards shallower reservoirs remain unidentified. Here we present geological evidence of failure of mechanically strong rocks due to the accumulation of CH4-H2-rich fluids at deep forearc depths, which ultimately reached supralithostatic pore fluid pressure. These fluids originated from adjacent reduction of carbonates by H2-rich fluids during serpentinization at eclogite-to-blueschist-facies conditions. Thermodynamic modeling predicts that the production and accumulation of CH4-H2-rich aqueous fluids can produce fluid overpressure more easily than carbon-poor and CO2-rich aqueous fluids. This study provides evidence for the migration of deep Earth energy sources along tectonic discontinuities, and suggests causal relationships with brittle failure of hard rock types that may trigger seismic activity at forearc depths.
Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment
Authors: Villa Matteo , Sanin David E. , Apostolova Petya , Corrado Mauro , Kabat Agnieszka M. , Cristinzio Carmine , Regina Annamaria , Carrizo Gustavo E. , Rana Nisha , Stanczak Michal A. , Baixauli Francesc , Grzes Katarzyna M. , Cupovic Jovana , Solagna Francesca , Hackl Alexandra , Globig Anna-Maria , Hässler Fabian , Puleston Daniel J. , Kelly Beth , Cabezas-Wallscheid Nina , Hasselblatt Peter , Bengsch Bertram , Zeiser Robert , Sagar  , Buescher Joerg M. , Pearce Edward J. , Pearce Erika L. 
Published: January 2024

AbstractImmune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establishment of the CD8+ T cell pool. CD8+ T cells progressively remodel their transcriptome and surface phenotype as they enter the gut wall, and downregulate expression of mitochondrial genes. Human and mouse intestinal CD8+ T cells have reduced mitochondrial mass, but maintain a viable energy balance to sustain their function. We find that the intestinal microenvironment is rich in prostaglandin E2 (PGE2), which drives mitochondrial depolarization in CD8+ T cells. Consequently, these cells engage autophagy to clear depolarized mitochondria, and enhance glutathione synthesis to scavenge reactive oxygen species (ROS) that result from mitochondrial depolarization. Impairing PGE2 sensing promotes CD8+ T cell accumulation in the gut, while tampering with autophagy and glutathione negatively impacts the T cell pool. Thus, a PGE2-autophagy-glutathione axis defines the metabolic adaptation of CD8+ T cells to the intestinal microenvironment, to ultimately influence the T cell pool.
Tracking a spin-polarized superconducting bound state across a quantum phase transition
Authors: Karan Sujoy , Huang Haonan , Ivanovic Alexander , Padurariu Ciprian , Kubala Björn , Kern Klaus , Ankerhold Joachim , Ast Christian R. 
Published: January 2024

AbstractThe magnetic exchange coupling between magnetic impurities and a superconductor induce so-called Yu-Shiba-Rusinov (YSR) states which undergo a quantum phase transition (QPT) upon increasing the exchange interaction beyond a critical value. While the evolution through the QPT is readily observable, in particular if the YSR state features an electron-hole asymmetry, the concomitant change in the ground state is more difficult to identify. We use ultralow temperature scanning tunneling microscopy to demonstrate how the change in the YSR ground state across the QPT can be directly observed for a spin-1/2 impurity in a magnetic field. The excitation spectrum changes from featuring two peaks in the doublet (free spin) state to four peaks in the singlet (screened spin) ground state. We also identify a transition regime, where the YSR excitation energy is smaller than the Zeeman energy. We thus demonstrate a straightforward way for unambiguously identifying the ground state of a spin-1/2 YSR state.
Unusual flexibility of transparent poly(methylsilsesquioxane) aerogels by surfactant-induced mesoscopic fiber-like assembly
Authors: Ueoka Ryota , Hara Yosuke , Maeno Ayaka , Kaji Hironori , Nakanishi Kazuki , Kanamori Kazuyoshi 
Published: January 2024

AbstractHigh-performance thermal insulators represented by aerogels are regarded as one of the most promising materials for energy savings. However, significantly low mechanical strength has been a barrier for aerogels to be utilized in various social domains such as houses, buildings, and industrial plants. Here, we report a synthetic strategy to realize highly transparent aerogels with unusually high bending flexibility based on poly(methylsilsesquioxane) (PMSQ) network. We have constructed mesoscopic fine fiber-like structures of various sizes in PMSQ gels by the combination of phase separation suppression by tetramethylammonium hydroxide (TMAOH) and mesoscopic fiber-like assembly by nonionic poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-b-PPO-b-PEO) type surfactant. The optimized mesoscale structures of PMSQ gels have realized highly transparent and resilient monolithic aerogels with much high bendability compared to those reported in previous works. This work will provide a way to highly insulating materials with glasslike transparency and high mechanical flexibility.