bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Therapeutic Education for Patients With Rheumatoid Arthritis Treated With Biologics
Authors: Bouden Selma , Ayed Hiba Ben , Khemir Haifa , Rouached Leila , Tekaya Aicha Ben , Mahmoud Ines , Tekaya Raoudha , Saidane Olfa , Abdelmoula Leila 
Published: February 2025

ABSTRACTIntroductionWe aimed to assess the effects of a patient therapeutic education (PTE) programme on the course of the disease and treatment management skills in rheumatoid arthritis (RA) patients treated with biologics.MethodsFrom January to December 2023, 52 RA patients participated in a face‐to‐face education session of 1 h, delivered to groups of four to six patients by 2 rheumatologists qualified in PTE. Disease activity, quality of life parameters and patient's skills using the BioSecure score were assessed before the education programme and 3 months later.ResultsA statistically significant decrease in mean pain visual Analogue Scale (p = 0.001), mean morning stiffness duration (p = 0.002), mean number of night awakenings (p = 0.01), mean tender joints count (p = 0.001) and mean 28‐Disease‐activity‐score (p = 0.001) were observed 3 months after the PTE. A statistically significant decrease in functional status (HAQ) and fatigue scores (FACIT‐F) was observed after PTE (p = 0.03 and p = 0.001, respectively). The mean BioSecure score climbed from 47.9 ± 14.9 at baseline to 74.8 ± 12.9 after PTE (p = 0.001). The variation of BioSecure score was significantly more important in patients with third‐level education, patients receiving subcutaneous biotherapy and those on TNF alpha inhibitors therapy.ConclusionPTE may be effective in improving clinical outcomes and safety skills in RA patients receiving biological treatment.
Novel High‐Order Alternative Finite Difference Central WENO Schemes for Hyperbolic Conservation Laws
Authors: Gao Zhen , Tang Zi‐Yu , Wang Bao‐Shan , Zhao Ya‐Ru 
Published: February 2025

ABSTRACTThe fifth‐order alternative finite difference weighted essentially non‐oscillatory (A‐WENO5) scheme is dominated by the truncation error of interpolation, resulting in a loss of one order of accuracy, despite the sixth‐order Taylor expansion of flux terms. In this study, we introduce the central WENO (CWENO) interpolation process in the A‐WENO5 framework to recover the optimal order and design fifth‐ and sixth‐order alternative CWENO schemes for solving the hyperbolic conservation laws. The key point is to enhance the interpolation procedure of the central stencil to realize the optimal sixth‐order accuracy. The linear weights are determined through approximate dispersion relation analysis, which also indicates a significant reduction in numerical dissipation compared with the A‐WENO5 scheme. Combining affine‐invariant WENO operators and Taylor analysis, the new local and global smoothness indicators are designed. The proposed schemes present many benefits, including lower dissipation, optimal order in truncation error, flexibility in choosing linear weights, and fewer CPU timings besides capturing the discontinuous solutions without numerical oscillations in contrast to the classical A‐WENO5 scheme.
Diseases and Traumas of Pleistocene Megafauna: A Perspective From Poland
Authors: Pawłowska Kamilla , Chrószcz Aleksander , Poradowski Dominik , Kubiak‐Nowak Dominika , Borawski Wojciech 
Published: February 2025

ABSTRACTAnalysis of pathologies can shed light on the health, trauma, and disease states of animals in the past. This study aims to explore the health status of megafauna during the Pleistocene and Holocene in Poland and to elucidate the diseases afflicting them, in order to gain a broader picture of the physical condition of these animals. For this purpose, species that show pathological lesions were macroscopically studied, and CT images were used for reconstruction. These results are supplemented with previously published data. Our results show cases of traumatic lesions, inflammatory diseases, arthropathies, diseases associated with the environment, dental anomalies and oral pathology, congenital anomalies and inherited disorders, and others. Lesions were found on the skeletal elements of woolly rhinoceroses, woolly mammoths, aurochs, bovids, giant deer, elks, and bears. The diversity of pathological cases and taxa demonstrated here is the first contribution to empirical pathological research in Polish paleozoology dealing with Quaternary records. Besides this, the research presented in this paper contributes to building a bridge between paleozoology and zooarcheology in support of what we call the “one pathology” concept.
Binding of Selected Ligands to Human Protein Disulfide Isomerase and Microsomal Triglyceride Transfer Protein Complex and the Associated Conformational Changes: A Computational Molecular Modelling Study
Authors: Yang Yong Xiao , Li Peng , Zhu Bao Ting 
Published: February 2025

AbstractHuman protein disulfide isomerase (PDI) is a multifunctional protein, and also serves as the β subunit of the human microsomal triglyceride transfer protein (MTP) complex, a lipid transfer machinery. Dysfunction of the MTP complex is associated with certain disease conditions such as abetalipoproteinemia and cardiovascular diseases. It is known that the functions of PDI or the MTP complex can be regulated by the binding of a small‐molecule ligand to either of these two proteins. In the present study, the conformational changes of the MTP complex upon the binding of three selected small‐molecule ligands (17β‐estradiol, lomitapide and a phospholipid) are investigated based on the available biochemical and structural information by using the protein–ligand docking method and molecular dynamics (MD) simulation. The ligand‐binding sites, the binding poses and binding strengths, the key binding site residues, and the ligand binding‐induced conformational changes in the MTP complex are analyzed based on the MD trajectories. The open‐to‐closed or closed‐to‐open transitions of PDI is found to occur in both reduced and oxidized states of PDI and also independent of the presence or absence of small‐molecule ligands. It is predicted that lomitapide and 1,2‐diacyl‐sn‐glycero‐3‐phosphocholine (a phospholipid) can bind inside the lipid‐binding pocket in the MTP complex with high affinities, whereas 17β‐estradiol interacts with the lipid‐binding pocket in addition to its binding to the interface region of the MTP complex. Additionally, lomitapide can bind to the b’ domain of PDI as reported earlier for E2. Key residues for the ligand‐binding interactions are identified in this study. It will be of interest to further explore whether the binding of small molecules can facilitate the conformational transitions of PDI in the future. The molecular and structural insights gained from the present work are of value for understanding some of the important biological functions of PDI and the MTP complex.
Stakeholders support marine eco‐engineering, but what are the perceived benefits and who should pay?
Authors: Dodds Kate C. , Vozzo Maria L. , Mayer‐Pinto Mariana , Dafforn Katherine A. , Bishop Melanie J. 
Published: February 2025

Abstract

Despite the ecological and socio‐economic benefits of nature‐based solutions (NbS), the application of ecological principles to the design of seawalls (termed ‘seawall eco‐engineering’) to mitigate their impacts remains low.

We investigated stakeholder perspectives of, support for and willingness to pay (WTP) for seawall eco‐engineering in one of the most diverse and urbanised harbours in the world, Sydney Harbour, in Australia.

Using a series of workshops and surveys targeting the general public, Local Government, built environment and natural environment professionals, we identified and ranked perceived risks and benefits of eco‐engineering seawalls, the most common infrastructure in the Harbour. Additionally, WTP for seawall eco‐engineering was investigated using an existing, large‐scale eco‐engineering project.

Overall, workshop participants rated benefits of seawall eco‐engineering to be almost double the risks. The key perceived benefits were increased habitat/biodiversity, improved water quality and enhanced environmental stewardship/awareness. Key perceived risks were potential damage to infrastructure and use of greenwashing to facilitate new development.

Across all stakeholder groups, participants were very supportive of statements regarding the benefits of eco‐engineered seawalls and the need for eco‐engineering principles to be included in the design of new seawalls. Despite strong support for seawall eco‐engineering, WTP was estimated at one third of the actual cost and was, in part, attributable to a lack of a shared evidence base from successful projects, and unclear guidance and policy around implementation.

Synthesis and applications: Our results showed that establishing rigorous monitoring and evaluation programs that facilitate cost–benefit analyses are critical to enhancing WTP for and uptake of eco‐engineering projects. Furthermore, more cost‐effective technologies and shared funding models may overcome existing financial impediments. We also found integrative legislation may be key to increased implementation of such NbS, given that existing policies were viewed as unsupportive.

Read the free Plain Language Summary for this article on the Journal blog.
Linking Caregivers' Evaluation of Children's Mood to Brain Network
Authors: Wong Neng Chio , Hu Zhishan , Cheng Wenhong 
Published: February 2025

ABSTRACTUsing functional near‐infrared spectroscopy technique, this study identified lower brain network efficiency in children with anxiety and/or depression compared to healthy controls, with caregivers' evaluation of mood correlating with brain network efficiency.
Towards a Responsible Implementation of NIPT as a First‐Tier Test in Canada: Decision‐Makers’ Perspectives
Authors: Roy Marie‐Christine , Malo Marie‐Françoise , Morel‐Laforce Tierry , Ravitsky Vardit , Laberge Anne‐Marie 
Published: February 2025

ABSTRACTObjectiveTo explore decision makers' perspectives on the conditions for a responsible implementation of non‐invasive prenatal testing (NIPT) as a first‐tier test in Canadian provinces' healthcare systems.MethodA qualitative study was conducted with 16 Canadian decision makers who were interviewed between February 2021 and July 2022. After anonymization and transcription, interviews were coded inductively using thematic analysis.ResultsOur interviews showed the complexity of the decision making environment regarding prenatal screening funding. Participants agreed that NIPT is superior to maternal serum screening as a first‐tier test, but they also recognized that first‐tier NIPT has limits and barriers. They described the following conditions for its responsible implementation: (1) need for time and evidence; (2) taking stakeholders' perspectives into account; (3) limit costs for the healthcare system; (4) ensure appropriate logistical conditions and harmonize the test offer; (5) ensure appropriate clinical services; (6) ensure informed consent; (7) ensure the test is presented as an individual choice to avoid eugenic concerns.ConclusionMultiple barriers and issues need to be addressed before moving NIPT from second‐ to first‐tier. Decision makers' perspectives should be contrasted with those of other important stakeholders, including pregnant people, disability advocates and healthcare professionals.
Efficiency Enhancement of CZTSSe Solar Cells via Thermal Treatment of (Zn, Mg)O Buffer Layers for Improving Crystallinity and Reducing Point Defects
Authors: Wang Yafei , Han Junsu , Tao Shengye , Dong Liangzheng , Gong Qianming , Wang Hanpeng , Jia Mengyao , Wu Zhihao , Baranova Maria , Zhou Jihui , Zhao Ming , Zhuang Daming 
Published: February 2025

ABSTRACTThe application of (Zn, Mg)O buffer layers significantly improves the energy band alignment and the interface quality of the heterojunction of CZTSSe solar cells, leading to a breakthrough in power conversion efficiency (PCE). However, (Zn, Mg)O thin films prepared by sputtering typically exhibit poor crystallinity, limiting their application. Rapid thermal processing (RTP) and substrate heating during the sputtering are investigated to address this issue. Our study demonstrates the effectiveness of RTP in reducing oxygen vacancies (VO) and adsorbed oxygen (Oad). Furthermore, it is identified that both thermal treatments increase the MgZn/(MgZn + Zn) ratio of (Zn, Mg)O thin films, thereby increasing their band gap. A notable improvement in the device performance of CZTSSe solar cells, particularly in fill factor (FF) and open‐circuit voltage (VOC), is achieved by adopting optimal thermal treatment processes. Power conversion efficiencies (PCEs) of 12.4% and 12.3% are obtained through RTP and substrate heating, which are remarkably improved compared with the untreated CZTSSe solar cells with the maximum PCE of 9.5%. Notably, 12.4% is the highest PCE for CZTSSe solar cells with (Zn, Mg)O buffers to date.
School‐Based Mental Health Programs, Protective, and Psychosocial Factors Associated With Psychological Distress Among Filipino School‐Going Adolescents
Authors: Mallari Earl Francis I. , Peltzer Karl 
Published: February 2025

ABSTRACTThe prevalence of psychological distress is increasing in the Philippines, a country with limited resources for mental health programs. It is worthy to investigate the possible predictors for psychological distress among Filipino youth as they are one of the vulnerable populations to psychological distress. The present study aimed to explore the school‐based mental health programs, protective factors, and psychosocial factors associated with psychological distress among Filipino school‐going adolescents. This study analyzed the 2019 Philippine Global School‐based Health Survey, which involved 10,175 high school‐going adolescents. Logistic regression was used to determine factors associated with psychological distress (loneliness, anxiety, suicidal ideation, plan or attempt). Results indicate that almost three out of every 10 (27.8%) Filipino school‐going adolescents reported experiencing psychological distress. In the adjusted model, having been taught about depression and suicide, taught what to do if a friend is suicidal, current alcohol use, current drug use, sedentary behavior, bullying victimization, and physically attacked were positively associated with psychological distress. Conversely, male sex, attending a public school, parental understanding, and having close friends were negatively associated with psychological distress. Psychological distress among Filipino school‐going adolescents has nearly doubled since 2015. School‐based mental health programs including suicidal content, demographic and psychosocial factors increased the likelihood of psychological distress and protective factors and having been taught about stress management decreased the odds of psychological distress.
Teacher Professional Identity on Teacher Empathy: The Moderating Roles of Competence and Growth Values and Ego‐Resilience
Authors: Sun Changkang , Zhuang Linyi , Xiao Weilong , Li Xinwei , Sun Binghai 
Published: February 2025

ABSTRACTTeacher empathy is important in reducing students' aggressive behavior, strengthening interpersonal cooperation, and promoting prosocial behavior. Previous research has shown that empathy could be predicted by a teacher's professional identity, but little is known about the moderating factors affecting the relationship between professional identity and teacher empathy. This study was conducted to examine the moderating roles of competence and growth values, and ego‐resilience in the relationship between teacher professional identity and empathy. Using the convenience sampling method, 1200 teachers from kindergarten, primary, and secondary schools participated in this study by using an online network platform. Regression analysis was used to examine the moderating effects. These results showed that: (1) Teacher empathy was positively associated with teacher professional identity; (2) when teachers have high levels of competence and growth values and ego‐resilience, the influenced effect of professional identity on empathy was the most. Improving teachers' professional identity, competence and growth values, and ego‐resilience could strengthen teachers' empathy.
Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries
Authors: Silvola Rebecca , O'Kane Aislinn , Heathman Michael , Marotta Hannah , Trussel Hayley , Ray Bobbie , Dowden Shelley , Masters Andrea R. , Haas David M. , Quinney Sara K. 
Published: February 2025

ABSTRACTEnhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21 healthy singleton pregnant individuals, ≥ 18 years old, undergoing CD and planning to breastfeed. Participants received 300 mg oral gabapentin before CD and every 6 h for 48 h per hospital protocol. Serial maternal plasma and breast milk samples were collected over a single dosing interval. Gabapentin pharmacokinetics were assessed using two structurally distinct population pharmacokinetic (POPPK) models to describe transfer of drug into breast milk utilizing (A) milk‐to‐plasma ratio and (B) inter‐compartmental rate constants. These models were then used to estimate exposure to breastfed infants. Postpartum gabapentin plasma concentrations fit a 1‐compartment model that was adapted to include breast milk concentrations. The two POPPK models both estimated relative infant doses (RID0–48h) of gabapentin < 0.15% of maternal dose within the first 48 h postpartum. Infant daily dose (IDD) from 24 to 48 h was estimated to be 0.0137 (0.0058–0.0316) mg/kg/day and 0.0139 (0.00041–0.0469) mg/kg/day by models A and B, respectively. These findings indicate limited neonatal exposure to gabapentin administered as part of a postpartum enhanced recovery after surgery protocol.
Homozygous FIGLA missense variant in two Japanese sisters with primary ovarian insufficiency: Case reports and literature review
Authors: Tanikawa Wataru , Saitsu Hirotomo , Nakamura Yasuhiko , Shirafuta Yuichiro , Fujisawa Yasuko , Fukami Maki , Sugino Norihiro , Ogata Tsutomu 
Published: February 2025

AbstractBackgroundFIGLA is a transcription factor gene which plays a critical role in folliculogenesis. Consistent with this, FIGLA variants have been identified in females with non‐syndromic primary ovarian insufficiency (POI) in both autosomal‐dominant and autosomal‐recessive forms.Case DescriptionWe encountered two Japanese sisters who had secondary or primary amenorrhea at 15 years of age. They were diagnosed as having non‐syndromic primary ovarian insufficiency (POI) with hypergonadotropic hypoestrogenism and markedly low serum anti‐Müllerian hormone values.OutcomeWhole genome sequencing revealed a novel homozygous missense variant, NM_001004311.3:c.338A>G:p.(Tyr113Cys), in FIGLA essential for folliculogenesis in the two sisters. The parents were heterozygous for this variant, and the heterozygous mother had regular menses at 51 years of age. This variant was extremely rare in public databases, and was invariably assessed as deleterious by six prediction tools. Furthermore, the p.(Tyr113Cys)‐FIGLA protein was assessed as “pathogenic” or “likely pathogenic” by protein structural predictions, and was evaluated as “destabilizing” or “decrease stability” by protein stability predictionsConclusionThe results, in conjunction with the data reported in the literature, imply that FIGLA variants account for a small but certain fraction of non‐syndromic POI, and pose a question as to the relevance of FIGLA variants to an autosomal dominant form of POI, although FIGLA variants have been identified in both autosomal dominant and autosomal recessive forms of non‐syndromic POI.
Robustifying Marginal Linear Models for Correlated Responses Using a Constructive Multivariate Huber Distribution
Authors: Mohammadi Raziyeh , Kazemi Iraj 
Published: February 2025

ABSTRACTThe marginal regression model is convenient for analyzing correlated responses, including repeated measures and longitudinal data. This paper proposes a robust marginal linear model for analyzing a vector of univariate responses with correlated components by incorporating an innovative multivariate Huber distribution. It employs a flexible parameterization using modified Cholesky decomposition, provides a convenient approach for estimating the covariance matrix, and allows for subject‐varying the tuning parameter. Our research introduces a method for estimating parameters by employing the exact likelihood function through the Hamiltonian Monte Carlo algorithm. To highlight the advantage of our model, we carried out a simulation experiment and reanalyzed two real‐world case studies in the health and economics fields. The results indicate that our model offers a more robust analysis by assigning appropriate weights to extreme observations, thereby handling outliers more effectively than traditional models.
Synergistic Catalysis in Fe─In Diatomic Sites Anchored on Nitrogen‐Doped Carbon for Enhanced CO2 Electroreduction
Authors: Meng Dapeng , Zheng Jingxuan , Guo Junxin , Zhang Anyu , Wang Zhao 
Published: February 2025

AbstractDiatomic catalysts are promising for the electrochemical CO2 reduction reaction (CO2RR) due to their maximum atom utilization and the presence of multiple active sites. However, the atomic‐scale design of diatomic catalysts and the elucidation of synergistic catalytic mechanisms between multiple active centers remain challenging. In this study, heteronuclear Fe─In diatomic sites anchored on nitrogen‐doped carbon (FeIn DA/NC) are constructed. The FeIn DA/NC electrocatalyst achieves a CO Faradaic efficiency exceeding 90% across a wide range of applied potentials from −0.4 to −0.7 V, with a peak efficiency of 99.1% at −0.5 V versus the reversible hydrogen electrode. In situ, attenuated total reflection surface‐enhanced infrared absorption spectroscopy and density functional theory calculations reveal that the synergistic interaction between Fe and In diatomic sites induce an asymmetric charge distribution, which promote the adsorption of CO2 at the Fe site and lowered the energy barrier for the formation of *COOH. Moreover, the unique Fe─In diatomic site structure increase the adsorption energy of *OH through a bridging interaction, which decrease the energy barrier for water dissociation and further promoted CO2RR activity.