bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Kesehatan Gigi dan Mulut Bagi Siswa SD di Kecamatan Manggar, Belitung Timur
Authors: Rifky Mirna F. , Puspita Susi R , Ruslan Mutiara Rina 
Published: February 2024

Penyakit gigi dan mulut merupakan masalah kesehatan yang cukup banyak diderita oleh masyarakat Indonesia dan merupakan hal yang sepatutnya diberi perhatian secara saksama oleh tenaga kesehatan medis, khususnya dokter gigi ataupun perawat gigi. Faktor tingkat pengetahuan dan kesadaran yang rendah mengenai kesehatan gigi dan mulut menyebabkan seseorang tidak mengetahui penyebab dan pencegahan karies gigi. Kegiatan pengabdian masyarakat FKG UPDM(B) diikuti oleh 11 orang peserta dokter gigi dan 60 orang mahasiswa program profesi FKG UPDM(B). Kegiatan pengabdian masyarakat bertempat di Gedung SMAN 1 Kecamatan Manggar, Belitung Timur dengan sasaran peserta siswa SD di sekitar kecamatan Manggar sebanyak 300 orang. Pelayanan yang dilakukan berupa penyuluhan kesehatan gigi dan mulut, pembagian sikat gigi dan pasta gigi serta edukasi kepada anak-anak, sebagai upaya promosi kesehatan gigi dan mulut. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan di bidang kesehatan gigi dan mulut untuk anak-anak sejak dini, Kegiatan pengabdian Masyarakat Fakultas Kedokteran Gigi Universitas Prof. Dr. Moestopo (Beragama) dilaksanakan di Gedung SMAN1 Kecamatan Manggar, Belitung Timur. Diharapkan kegiatan penyuluhan kesehatan gigi dan mulut ini dilakukan secara terprogram dan berkelanjutan, serta mendapat dukungan dari berbagai pihak terutama masyarakat dan pemerintah setempat secara konsisten
Bimbingan Karier bagi Pelajar SMA Negeri 1 Bajawa Kabupaten Ngada
Authors: Sando Martinus Valdino Wonda , Bulor Rosa Mustika , Tukan Gerardus Diri , Nggabut Giovani Don Bosco , Rani Maria Ersilia Melly 
Published: February 2024

Siswa siswi Sekolah Menengah Atas Negeri 1 Bajawa kabupaten Ngada, diketahui belum memiliki pengetahuan yang memadai tentang karier. Kondisi itu ditemukan dalam diskusi nonformal bersama beberapa siswa yang berdomisili di Kelurahan Tanalodu sehingga mendasari pelaksanaan kegiatan bimbingan karier bagi siswa siswi kelas XII Sekolah Menengah Atas Negeri 1 Bajawa. Tujuan kegiatan ini yaitu memberikan pengetahuan kepada siswa siswi tentang karier masa depan, membuka pikiran serta mempersiapkan mereka untuk merencanakan karier masa depan sejak dini. Metode pelaksanaan kegiatan yaitu ceramah dan diskusi. Kegiatan dilaksanakan di Aula Sekolah Menengah Atas Negeri 1 Bajawa, sesuai kesepakatan dengan pihak sekolah. Hasil kegiatan yang dicapai yaitu para siswa siswi peserta kegiatan antusias mengikuti kegiatan, Materi kegiatan yang disajikan tampak dipahami secara baik oleh para peserta kegiatan. Antusiasme dan pemahaman para siswa siswi peserta kegiatan terhadap kegiatan dan materi kegiatan yang disajikan, ditunjukkan melalui keterlibatan aktif para siswa peserta kegiatan dalam mengajukan pertanyaan dan memberikan pendapat saat diskusi. Para siswa juga tampak berani menyampaikan tentang rencana masa depannya setelah menamatkan jenjang Sekolah Menengah Atas. Para siswa menyatakan senang karena memperoleh informasi tentang karier masa depan dan harus menyiapkan diri dan mempunyai rencana lebih awal serta menyatakan mebutuhkan informasi sesuai kegiatan yang telah dilakukan.
Leader Investigation Strategies In The Development Of Marketing Environments To Forther Competitiveness In PT. Prudential Financial Binjai
Authors: Lintangdwiyana Lintangdwiyana , Ramadhani Sri , Bi Rahmani Nur Ahmadi 
Published: February 2024

Strategy is a unified, comprehensive and integrated plan that links the advantages of corporate strategy with environmental challenges and that is designed to ensure that the company's main objectives can be achieved through proper execution by the company. The purpose of this study is to examine more deeply the leadership strategy of leaders in developing marketers to increase competitive advantage at PT. Prudential Sharia Binjai. And to find out the success rate of a leader or leader in developing marketers. The method used is a qualitative descriptive method. Research is written using descriptive where research related to questions through interviews with leaders in a company to obtain results by observing and managing data. The results of this study show the success or success of a leader or leader seen from several factors, namely, agents have increased income, achievement of contests, achievement of travel trips and achievement of MDRT. The strategy used by leaders to develop marketers to increase competitive advantage in the company is to use a communication strategy, where communication is a very important role in increasing competitiveness.
High School Students Mental Health Support and Treatment via Mental Health Clinic
Authors: Boonboot Kobkaew , Khamkaew Suthee , Moonphol Chidapan 
Published: February 2024

This study aimed to determine high school students' mental health concerns and to show what a psychologist and guidance teachers can do to help students with mental health challenges be most successful of grade 7-12 students and students’ parents in the academic years of 2018-2022 at Wat Phrasrimahadhat Secondary Demonstration School, Phranakhon Rajabhat University, Thailand. The instrument was the consultation record, which kept all records of the participants by the psychologist and the guidance teacher at the mental health clinic. The psychologist and guidance teacher developed the consultation records based on the functional patterns. The results were interpreted, categorized, and tabulated on computer sheets. The findings revealed that there were 82 cases from 2018-2022 in which the mental health clinic provided a range of mental health services. Most mental health concerns were low self-esteem (18 cases), depression or withdrawal (16 cases) and anxiety (10 cases), respectively. Moreover, after going to the mental health clinic, a psychologist could help students and students’ parents work through such mental health problems, accounting for 62 cases out of 82. 11 cases were still to continue sessions with a psychologist. Besides, nine cases were transferred to the specialist in the hospital based on the parents’ permission.
Parrots, Princes, and Popes: Translatio Imperii in Jean Clouet’s Portrait of Francis I as St. John the Baptist
Authors: DuVall Emily 
Published: February 2024

At first glance, a green parrot featured in Jean Clouet’s Portrait of François Ier as St. John the Baptist appears out of place. The parrot was a prized import that graced Europe upon Alexander the Great’s victorious return from the Persian Empire and India. Why is this foreign bird exhibited in a sixteenth-century French royal portrait? Repeated in a portrait of François’ sister, it becomes apparent that the green parrot was no casual inclusion. François’ green parrot contains a complex visual message. Considering the implications of the parrot and the ambitions of François, this paper will argue that the appearance of this particular bird served to glorify and endorse a new branch of the royal House of Valois.
Development of an activatable far-red fluorescent probe for rapid visualization of hypochlorous acid in live cells and mice with neuroinflammation
Authors: Mi Long , Niu Changhe , Chen Jianqiang , Han Feng , Ji Xueying 
Published: February 2024

Recent investigations have suggested that abnormally elevated levels of HOCl may be tightly related to the severity of neuroinflammation. Although some successes have been achieved, fluorescent probes with far-red fluorescence emission and capable of detecting HOCl with high specificity in pure aqueous solution are still urgently needed. Herein, a responsive far-red fluorescent probe, DCI-H, has been constructed to monitor HOCl activity in vivo and in vitro. DCI-H could rapidly respond to HOCl within 120 s and had a low detection limit for HOCl of 1.5 nM. Importantly, physiologically common interfering species, except for HOCl, did not cause a change in the fluorescence intensity of DCI-HOCl at 655 nm. The results of confocal imaging demonstrated the ability of DCI-H to visualize endogenous HOCl produced by MPO-catalyzed H2O2/Cl− and LPS stimulation. With the assistance of DCI-H, upregulation of HOCl levels was observed in the mice model of LPS-induced neuroinflammation. Thus, we believed that DCI-H provided a valuable tool for HOCl detection and diagnosis of inflammation-related diseases.
Application of plasma metagenomic next-generation sequencing improves prognosis in hematology patients with neutropenia or hematopoietic stem cell transplantation for infection
Authors: Chen Yuhui , Wang Jinjin , Gan Xinai , Li Meng , Liao Yi , Zhou Yongzhao , Niu Ting 
Published: February 2024

IntroductionMetagenomic next-generation sequencing (mNGS) is a novel technique for detecting pathogens. This retrospective study evaluated the diagnostic value of mNGS using plasma for infections in hematology patients and its impact on clinical treatment and prognosis in different subgroups of hematology patients.MethodsA total of 153 hematology patients with suspected infection who underwent mNGS using plasma were enrolled in the study. Their clinical histories, conventional microbiological test (CMT) results, mNGS results, treatment and prognosis were retrospectively analyzed.ResultsIn 153 plasma samples, mNGS yielded a higher positivity rate than CMT (total: 88.24% vs. 40.52%, P&lt;0.001; bacteria: 35.95% vs. 21.57%, P &lt; 0.01; virus: 69.93% vs. 21.57%, P&lt;0.001; fungi: 20.26% vs. 7.84%, P&lt;0.01). mNGS had a higher positivity rate for bacteria and fungi in the neutropenia group than in the non-neutropenia group (bacteria: 48.61% vs. 24.69%, P&lt;0.01; fungi: 27.78% vs. 13.58%, P&lt;0.05). mNGS demonstrated a greater advantage in the group of patients with hematopoietic stem cell transplantation (HSCT). Both the 3-day and 7-day efficacy rates in the HSCT group were higher than those in the non-HSCT group (3-day: 82.22% vs. 58.65%, P &lt; 0.01; 7-day: 88.89% vs. 67.31%, P &lt; 0.01), and the 28-day mortality rate was lower in the HSCT group than in the non-HSCT group (6.67% vs. 38.89%, P &lt; 0.000). The neutropenia group achieved similar efficacy and mortality rates to the non-neutropenia group (7-day efficiency rate: 76.39% vs. 71.43%, P &gt; 0.05; mortality rate: 29.17% vs. 29.63%, P &gt; 0.05) with more aggressive antibiotic adjustments (45.83% vs. 22.22%, P &lt; 0.01).ConclusionmNGS can detect more microorganisms with higher positive rates, especially in patients with neutropenia. mNGS had better clinical value in patients with hematopoietic stem cell transplantation (HSCT) or neutropenia, which had a positive effect on treatment and prognosis.
Risk of cardiovascular toxicity with combination of immune-checkpoint inhibitors and angiogenesis inhibitors: a meta-analysis
Authors: Inno Alessandro , Veccia Antonello , Madonia Giorgio , Berti Alvise , Bortolotti Roberto , Incorvaia Lorena , Russo Antonio , Caffo Orazio , Gori Stefania 
Published: February 2024

IntroductionCombinations of immune checkpoint inhibitors (ICIs) and angiogenesis inhibitors (AIs) have been investigated for the treatment of several tumor types. Both ICIs and AIs may lead to cardiovascular adverse events, and their combination may potentially increase the risk for cardiovascular toxicity. In the present meta-analysis, we aim to assess the cardiovascular toxicity of ICIs plus AIs vs. AIs alone. Secondary objectives are non-cardiovascular adverse events and efficacy.MethodsSystematic review was performed according to PRISMA statement. Phase II and III randomized clinical trials were identified by searching the MEDLINE/PubMed, Cochrane Library and ASCO Meeting abstracts, from inception to June 2022. The pooled risks for overall response rate (ORR), 1-year progression-free survival (PFS), adverse events (AEs), immune-related AEs, (irAEs), hypertension, and vascular events defined as stroke, myocardial infarction and pulmonary embolisms, were calculated.ResultsIn terms of cardiovascular toxicity, we found higher risk for severe hypertension among patients treated with ICIs plus AIs as compared with those receiving AIs (OR 1.24, 95% CI: 1.01–1.53), but no significant difference was found for any-grade hypertension, and for vascular events. There was also no difference in terms of overall AEs, whereas the incidence of irAEs was increased in the ICIs plus AIs arm, as expected. In terms of efficacy, ICIs plus AIs achieved better ORR (OR 2.25, 95% CI: 1.70–2.97) and PFS (HR 0.49, 95% CI: 0.39–0.63) as compared to AIs alone.ConclusionThe addition of ICIs to AIs significantly increased the risk of high-grade hypertension, but not that of acute vascular events.
Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort
Authors: Sheerin Christina M. , O’Hara-Payne Rowan K. , Lancaster Eva E. , Suarez-Rivas Hailie ,   Spit for Science Working Group, Chatzinakos Chris , Prom-Wormley Elizabeth C. , Peterson Roseann E. 
Published: February 2024

Introduction: Genetic factors impact alcohol consumption and use disorder (AUD), with large-scale genome-wide association studies (GWAS) identifying numerous associated variants. Aggregate genetic methods in combination with important environmental factors (e.g., interpersonal trauma [IPT]) can be applied to expand our understanding of the ways by which genetic and environmental variables work together to influence alcohol consumption and disordered use. The present study aimed to detail the relationships between genome-wide polygenic scores (PGS) for alcohol phenotypes (i.e., alcohol consumption and AUD status) and IPT exposure as well as the interaction between them across ancestry.Methods: Data were drawn from the Spit for Science (S4S) study, a US college student population, where participants reported on IPT exposure prior to college and alcohol consumption and problems during college (N = 9,006; ancestry: 21.3% African [AFR], 12.5% Admixed Americas [AMR], 9.6% East Asian [EAS], 48.1% European [EUR], 8.6% South Asian [SAS]). Two trans-ancestry PGS were constructed, one for alcohol consumption and another for AUD, using large-scale GWAS summary statistics from multiple ancestries weighted using PRS-CSx. Regression models were applied to test for the presence of associations between alcohol-PGS and IPT main and interaction effects.Results: In the meta-analysis across ancestry groups, IPT exposure and PGS were significantly associated with alcohol consumption (βIPT = 0.31, PIPT = 0.0002; βPGS = 0.09, PPGS = 0.004) and AUD (ORIPT = 1.12, PIPT = 3.5 × 10−8; ORPGS = 1.02, PPGS = 0.002). No statistically significant interactions were detected between IPT and sex nor between IPT and PGS. When inspecting ancestry specific results, the alcohol consumption-PGS and AUD-PGS were only statistically significant in the EUR ancestry group (βPGS = 0.09, PPGS = 0.04; ORPGS = 1.02, PPGS = 0.022, respectively).Discussion: IPT exposure prior to college was strongly associated with alcohol outcomes in this college-age sample, which could be used as a preventative measure to identify students at high risk for problematic alcohol use. Additionally, results add to developing evidence of polygenic score association in meta-analyzed samples, highlighting the importance of continued efforts to increase ancestral representation in genetic studies and inclusive analytic approaches to increase the generalizability of results from genetic association studies.
Allergen immunotherapy combined with Notch pathway inhibitors improves HDM-induced allergic airway inflammation and inhibits ILC2 activation
Authors: Tong Yu , Wang Lei , Wang Lingya , Song Jingjing , Fan Junwen , Lai Chuqiao , Bao Jiali , Weng Cuiye , Wang Yufei , Shuai Jilong , Zhang Hui , Zhang Weixi 
Published: February 2024

IntroductionGroup 2 innate lymphoid cells (ILC2s) play a crucial role in house dust mite (HDM)-induced allergic inflammation, and allergen immunotherapy (AIT) holds promise for treating the disease by reducing the frequency of ILC2s. Despite significant progress in AIT for allergic diseases, there remains a need to improve the control of allergic symptoms.MethodsWe investigated the synergistic effect of the Notch signaling pathway and subcutaneous immunotherapy (SCIT) in treating allergic airway inflammation in mice and their impact on the ratio of ILC2s in lung tissues. This was achieved by establishing the HDM-induced airway allergic disorders (HAAD) model and SCIT model. Additionally, we conducted in vitro investigations into the effect of the Notch signaling pathway on the secretory function of activated ILC2s using fluorescence-activated cell sorting. Furthermore, we explored the coactivation of the Notch signaling pathway with SCIT in vitro by sorting ILC2s from the lung tissues of mice after SCIT modeling.ResultsPreviously, our group demonstrated that Notch signaling pathway inhibitors can reduce allergic airway inflammation in mice. Notch signaling induces lineage plasticity of mature ILC2s. In this study, we showed that AIT alleviates allergic airway inflammation and suppresses the frequency of ILC2s induced by HDM. Interestingly, AIT combined with a γ-secretase inhibitor (GSI), an inhibitor of the Notch signaling pathway, significantly inhibited the frequency of ILC2s, reduced airway inflammation, and suppressed Th2-type responses in a mouse model. Furthermore, lung ILC2s from HDM-challenged mice with or without AIT were treated with GSI in vitro, and we found that GSI dramatically reduced the secretion of type 2 inflammatory factors in ILC2s.DiscussionThese findings suggest that Notch signaling pathway inhibitors can be used as adjuvant therapy for AIT and may hold potential treatment value in the cooperative control of allergic airway inflammation during early AIT.
Global trends in research on MOG antibody-associated disease: bibliometrics and visualization analysis
Authors: Zheng Shuhan , Wang Yang , Geng Jiaming , Liu Xueyan , Huo Liang 
Published: February 2024

ObjectiveThe purpose of this study was to investigate the current research status, focus areas, and developmental trends in the field of Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) through an analysis of scientific literature.MethodsThe relevant research articles on MOGAD published from 1947 to 2022 were retrieved from the Web of Science database. The quantitative output of MOGAD related research articles, their distribution by country/region, data on collaborative publishing, influential authors, high-yield institutions, keywords, hotspots, and development trends were analyzed. Additionally, visual knowledge maps were generated using VOSviewer and Citespace.ResultsThere has been a steady increase in the number of MOGAD related publications indicating that the subject has garnered increasing interest among researchers globally. The United States has been the leading contributor with 496 papers (19.25%), followed by China (244, 9.63%), Japan (183, 7.10%), the United Kingdom (154, 5.98%), and Germany (149, 5.78%). Among these countries, the United Kingdom boasts the highest citation frequency at the rate of 46.49 times per paper. Furthermore, active collaboration in MOGAD related research is observed primarily between the United States and countries such as Canada, Germany, Australia, Italy, the United Kingdom and Japan. Mayo Clinic ranks first in total articles published (109) and frequency of citations per article (77.79). Takahashi Toshiyuki from Tohoku University is the most prolific author, while Multiple Sclerosis and Related Disorders is the most widely read journal in this field. “Disease Phenotype”, “Treatment”, “Novel Coronavirus Infection and Vaccination”, “Immunopathological Mechanisms”, “Clinical characteristics of children” and “Prognosis” are the primary keywords clusters in this field. “Novel Coronavirus Infection and Vaccination” and “Immunopathological Mechanisms” are research hotspots and have great development potential.ConclusionThe past three decades have witnessed a significant expansion of research on MOGAD. The pathogenetic mechanism of MOGAD is poised to be the prominent research focus in this field in the foreseeable future.
A new 4-gene-based prognostic model accurately predicts breast cancer prognosis and immunotherapy response by integrating WGCNA and bioinformatics analysis
Authors: Chen Wenlong , Kang Yakun , Sheng Wenyi , Huang Qiyan , Cheng Jiale , Pei Shengbin , Meng You 
Published: February 2024

BackgroundBreast cancer (BRCA) is a common malignancy in women, and its resistance to immunotherapy is a major challenge. Abnormal expression of genes is important in the occurrence and development of BRCA and may also affect the prognosis of patients. Although many BRCA prognosis model scores have been developed, they are only applicable to a limited number of disease subtypes. Our goal is to develop a new prognostic score that is more accurate and applicable to a wider range of BRCA patients.MethodsBRCA patient data from The Cancer Genome Atlas database was used to identify breast cancer-related genes (BRGs). Differential expression analysis of BRGs was performed using the ‘limma’ package in R. Prognostic BRGs were identified using co-expression and univariate Cox analysis. A predictive model of four BRGs was established using Cox regression and the LASSO algorithm. Model performance was evaluated using K-M survival and receiver operating characteristic curve analysis. The predictive ability of the signature in immune microenvironment and immunotherapy was investigated. In vitro experiments validated POLQ function.ResultsOur study identified a four-BRG prognostic signature that outperformed conventional clinicopathological characteristics in predicting survival outcomes in BRCA patients. The signature effectively stratified BRCA patients into high- and low-risk groups and showed potential in predicting the response to immunotherapy. Notably, significant differences were observed in immune cell abundance between the two groups. In vitro experiments demonstrated that POLQ knockdown significantly reduced the viability, proliferation, and invasion capacity of MDA-MB-231 or HCC1806 cells.ConclusionOur 4-BRG signature has the potential as an independent biomarker for predicting prognosis and treatment response in BRCA patients, complementing existing clinicopathological characteristics.