bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Parable of the Minas Address the Delay of the Parousia? Luke 19,11–27 in its Lukan, Rhetorical and Roman Settings
Authors: Gathercole Simon 
Published: February 2024

Abstract
The aim of this article is to question whether the parable of the minas (Lk. 19,11–27) is a reflection by Luke on the delay of the parousia. After a review of research showing that the delay-oriented interpretation of the parable has been prevalent for some time, there are four parts to the argument. First, in agreement with the delay hypothesis, it is argued (against a recent social-scientific interpretation) that the parable has allegorical features when compared with the portrait of Jesus in Luke-Acts (the “Lukan” setting). Secondly, examination of the parable and its frame in Luke 19,11 shows that Luke cannot straightforwardly be understood as applying the parable to a particular, contemporaneous eschatological concern (the “rhetorical” setting). Thirdly, the expeditions of royal claimants to Rome do not supply evidence for the “delay” reading of the parable because these journeys were not sufficiently cumbersome or protracted to imply delay in the parable (the “Roman” setting). Fourthly and finally, the article engages in exegesis of Luke 19,11–27 itself to show that the details of the parable do not point to a concern about delay on Luke’s part.
Paul and Jewish Sacrifices: Perspectives and Arguments
Authors: Pereira-Delgado Álvaro , Díez-Herrera Pablo 
Published: February 2024

Abstract
According to the traditional perspective, the early Christians refused to continue with the temple sacrifice. Christ on the cross had already atoned for all sins. Recently, other scholars, especially those belonging to the Radical New Perspective on Paul (or “Paul within Judaism” research), have argued instead that Paul carried on with temple worship, considered it efficacious, and expected Christ-following Jews to continue with the sacrifice. In this research we will investigate the positions of the different perspectives on Paul’s attitude toward Jewish sacrifices and evaluate the arguments at stake. Our research leads us to the conclusion that Paul did not consider the temple sacrifices a problem, but neither did he give them any salvific relevance for the recipients of his letters.
Review and Consideration of Apparent Negative Crack Growth in Fracture Toughness Tests
Authors: Lucon Enrico 
Published: February 2024

Abstract
Apparent negative crack growth is often encountered when performing elastic-plastic fracture toughness tests with the Elastic Compliance single-specimen technique. It consists of a decrease of specimen compliance (reduction of crack size) during the early portion of the test, before the attainment of maximum force and the onset of ductile crack extension. This phenomenon was recognized and discussed inside the fracture mechanics community since the mid-1980s, but widespread consensus was never achieved on its root causes and on the best approach to account for it in the analysis of an elastic-plastic fracture toughness test. It has been shown that both experimental (test setup) and material behavior aspects can be invoked to explain the decrease of elastic compliance that translates into decreasing crack size in the early loading stage. The current edition of ASTM E1820, Standard Test Method for Measurement of Fracture Toughness, does not offer provisions to handle this phenomenon, and users are left free to treat the issue as they see fit. In this study, several articles published in the last 40 years were reviewed, and different proposed methods were applied on 15 selected tests performed on specimens of different geometries and thicknesses. Comparisons between original crack sizes, ductile crack extensions, and critical toughness values are presented, and recommendations are provided for revising ASTM E1820 with due consideration of the occurrence of apparent negative crack growth.
Upregulated GIRK2 counteracts ethanol-induced changes in excitability & respiration in human neurons
Authors: Prytkova Iya , Liu Yiyuan , Fernando Michael , Gameiro-Ros Isabel , Popova Dina , Kamarajan Chella , Xuei Xiaoling , Chorlian David B. , Edenberg Howard J. , Tischfield Jay A. , Porjesz Bernice , Pang Zhiping P. , Hart Ronald P. , Goate Alison , Slesinger Paul A. 
Published: February 2024

Genome-wide association analysis (GWAS) of electroencephalographic endophenotypes for alcohol use disorder (AUD) has identified non-coding polymorphisms within theKCNJ6gene.KCNJ6encodes GIRK2, a subunit of a G protein-coupled inwardly-rectifying potassium channel that regulates neuronal excitability. How changes in GIRK2 affect human neuronal excitability and the response to repeated ethanol exposure is poorly understood. Here, we studied the effect of upregulatingKCNJ6using an isogenic approach with human glutamatergic neurons derived from induced pluripotent stem cells (male and female donors). Using multi-electrode-arrays, population calcium imaging, single-cell patch-clamp electrophysiology, and mitochondrial stress tests, we find that elevated GIRK2 acts in concert with 7-21 days of ethanol exposure to inhibit neuronal activity, to counteract ethanol-induced increases in glutamate response, and to promote an increase intrinsic excitability. Furthermore, elevated GIRK2 prevented ethanol-dependent changes in basal and activity-dependent mitochondrial respiration. These data support a role for GIRK2 in mitigating the effects of ethanol and a previously unknown connection to mitochondrial function in human glutamatergic neurons.Significance StatementAlcohol use disorder (AUD) is a major health problem that has worsened since COVID, affecting over 100 million people worldwide. While it is known that heritability contributes to AUD, specific genes and their role in neuronal function remain poorly understood, especially in humans. In the current manuscript, we focused on the inwardly-rectifying potassium channel GIRK2, which has been identified in an AUD-endophenotype genome-wide association study. We used human excitatory neurons derived from healthy donors to study the impact of GIRK2 expression. Our results reveal that elevated GIRK2 counteracts ethanol-induced increases in glutamate response and intracellular calcium, as well as deficits in activity-dependent mitochondrial respiration. The role of GIRK2 in mitigating ethanol-induced hyper-glutamatergic and mitochondrial offers therapeutic promise for treating AUD.
Growth hormone-secreting pituitary adenoma combined with Graves’ disease: retrospective case series and literature review
Authors: Mo Caiyan , Tong Tao , Guo Ying , Li Zheng , Zhong Liyong 
Published: February 2024

Purpose
The coexistence of growth hormone-secreting pituitary adenoma (GHPA) and Graves' disease (GD) is rare. This study aimed to investigate the relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) levels and thyroid function in patients with GHPA combined with GD and to explore the underlying mechanisms.

Methods
Eleven patients with GHPA combined with GD during 2015-2022 were collected by searching the medical record system of Beijing Tiantan Hospital, Capital Medical University. Changes in GH/IGF-1 levels and thyroid function were compared before and after the application of antithyroid drugs (ATD) and before and after transsphenoidal surgery (TSS) or somatostatin analog (SSA) treatment, respectively.

Results
After the application of ATD, with the decrease of thyroid hormone levels, GH/IGF-1 levels also decreased gradually. In patients without ATD application, after surgery or SSA treatment, thyroid hormone levels decreased as GH/IGF-1 decreased.

Conclusion
Hyperthyroidism due to GD promotes the secretion of GH/IGF-1, and when thyroid hormone levels were decreased by the use of ATD, GH and IGF-1 levels were also decreased, suggesting that thyroid hormones may influence the synthesis and secretion of GH/IGF-1. The use of ATD to control thyrotoxicosis before TSS is not only beneficial in reducing the risk of anesthesia but may help to promote biochemical control of GHPA. On the other hand, high levels of GH/IGF-1 in patients with GHPA also exacerbate GD hyperthyroidism, which is ameliorated by a decrease in GH/IGF-1 levels by TSS or SSA treatment, suggesting that the GH–IGF-1 axis promotes growth, thyroid function, and thyroid hormone metabolism.
Strategic priorities of industrial support of energy projects in the Arctic
Authors: Spiridonov A. A. , Fadeeva M. L. , Tolstykh T. О. 
Published: February 2024

The article deals with economic issues of support of energy projects in the Arctic based on the use of the industrial potential of the region on the example of the Murmansk region, a subject of the Russian Federation. The article contains justification of the administrative and economic mechanism of formation of the oil and gas cluster with small and medium-sized businesses as its core. The mechanism includes consistent implementation of several stages: analysis of industrial opportunities of regional suppliers, implementation of development programs, establishment of industry clusters, participation in tender procedures. The suggested mechanism will ensure increasing the share of participation of regional companies in realization of industrial projects and localization of production facilities.Special attention is paid to the challenges faced by the supplier companies of oil and gas industry and the ways to overcome them effectively. The article studies the mechanism of horizontal integration of regional supplier companies in order to perform a consolidated representation of their industrial potential when participating in tender procedures. The authors give considerable attention to the role of the state in realization of energy projects in the Arctic and to interaction with regional business communities when establishing oil and gas clusters on the territory of new mining regions.Involvement of small and medium-sized businesses in realization of major energy projects is an essential condition for the long-term development of economy. Many regional industrial enterprises possess unique competencies that may be in special demand in the conditions of the sanctions pressure and withdrawal of foreign companies from the Russian market. The authors especially focus on the formation of institutional conditions aimed at creating favourable environment for mutual integration of the interests of state, operators of energy projects and regional suppliers.
Scientific Truth on Crime Counteraction in the Works of Professor M.P. Kleymenov
Authors: Repetskaya Anna , Sudakova Tatiana 
Published: February 2024

The article is dedicated to the jubilee of a famous Russian criminologist Mikhail Petrovich Kleymenov. The versatility of research talents of this professor is connected with his initial interest in the multitude of crime counteraction problems. He authored over 340 research publications, including 11 monographs, 9 manuals in criminal law and criminology in which he studied complex problems of crime, as well as textbooks, including one that he wrote without co-authors. The sphere of Professor Kleymenov’s research interests is very wide, which reflects not only the multifaceted character of his “criminological talent”, but also his true interest in studying the multi-aspect problem of crime and crime counteraction, it is a logical consequence of the development of his research career. A constant desire to widen his knowledge is reflected in the dynamic research of actualizing and transforming spheres of criminal behavior. His loyalty to the development of theoretical and practical aspects of such areas as organized crime and crimes of corruption, unsolved crimes, criminal law and criminological prediction, interconnection between moral, cultural level, spirituality and criminal behavior, extremism and problems of criminological measurement makes it possible to deepen the available knowledge and considerably enrich research in this sphere. Being the founder of special theories of criminology (sport criminology, ethno-criminology, medical criminology), the professor has numerous disciples and his own school of research.
The analysis and review of all research achievements of professor M.P. Kleymenov requires a separate publication. His research and development of complex criminological problems, long-term and diversified work of studying different aspects of crime counteraction, and genuine interest in criminological theory have contributed and are still making a considerable contribution to crime counteraction, they are invaluable for both theory and practice.
Designers, makers, influencers: the contribution of William Halfpenny and Thomas Chippendale to the development English Chinoiserie furniture design
Authors: Tsoumas Johannis , Kertemelidou Paraskevi 
Published: February 2024

The term Chinoiserie, i.e. the tendency to incorporate elements of Chinese culture into European art and architecture, redefined the concept of style in seventeenth-century France and influenced the aesthetic formation of European arts and design in the century that followed. The term became particularly popular in England, as it was also associated with the need for renewal after the excessive ornamentation, elaborate symbolism and intense theatricality of Baroque, as well as the aesthetic and ideological perfection of Classicism. As early as the first half of the eighteenth century, the architect and designer William Halfpenny (1723-1755) showed a keen interest and skill in the transition from classical design to the mysterious Chinese motifs, contributing thus to the stylistic formation of English Chinoiserie, especially in the field of architecture and by extension furniture design. His experimentally pioneering approach through his publications was the beginning of a new aesthetic and ideological era that had a catalytic effect on the shaping of the design concept, taste and construction techniques of the equally important English furniture designer, Thomas Chippendale (1718-1779).
This research aims to highlight the establishment of Chinese culture and aesthetics, known as Chinoiserie, in the eighteenth-century England, as regards the formation of furniture design, through the pattern books and design experimentation of William Halfpenny, as well as the inspired publications and the manufacturing mastery of Thomas Chippendale.
JN.1 COVID-19: Variant of interest
Authors: Amalia Husnun , Mashabi Yasmine 
Published: February 2024

Corona Virus Disease-19 (COVID-19) adalah sindrom pernafasan akut yang disebabkan oleh virus Coronavirus 2 (SARS-CoV-2). WHO mengelompokkan virus SARS- CoV-2 menjadi dua kategori, yaitu variant of interest (VOI) dan variant of concern (VOC). Kategori VOI diberikan jika terdapat mutasi baru dengan implikasi fenotipenya bisa diduga dan harus terpenuhi satu mutasi yang menyebabkan transmisi lokal atau menyebabkan multipel klaster atau terdeteksi di beberapa negara. Pada September 2023 terdeteksi varian baru COVID 19 di Amerika Serikat, yaitu JN.1 sebagai VOI. Varian ini adalah variasi dari varian BA.2.86 dengan perbedaan hanya pada mutase 1 spike protein yaitu tambahan protein L455S pada varian JN.1. Varian ini memiliki potensi untuk menghindar dari system kekebalan tubuh. Secara global telah terjadi peningktan jumlah penderita secara pesat terutama di 3 wilayah WHO yaitu Amerika (AMR), Pasifik Barat (WPR) dan Eropa (EUR). Namun efektivitas vaksin monovalent terhadap varian ini masih dapat melindungi penderitanya. Beberapa penelitian menunjukkan bahwa risiko yang rendah untuk perawatan di rumah sakit pada kasus penderita lanjut usia dan usia muda.
Kadar Vitamin D dengan Sindrom Mata Kering pada Karyawan
Authors: Margo Eveline , Meiyanti Meiyanti , Kartadinata Erlani , Kartadinata Noviani 
Published: February 2024

Latar Belakang Sindrom mata kering (DES) penyakit mata yang paling sering dijumpai dengan prevalensi di dunia sekitar 5 – 50%. Di Indonesia sendiri prevalensi DES sekitar 27.5%. DES disebabkan oleh banyak faktor yang menunjukkan inflamasi memegang peranan penting dalam patofisiologinya. Akibat adanya inflamasi akan menyebabkan peningkatan stress oksidatif yang dapat menyebabkan penurunan produksi air mata, dan inflamasi pada permukaan okuler dapat menyebabkan peningkatan penguapan air mata yang berlebihan sehingga menyebabkan ketidakstabilan lapisan air mata. Vitamin D mempunyai efek anti inflamasi. Peranan vitamin D pada mata melalui vitamin D reseptor (VDR) yang terekspresi pada epitel pigmen retina, fotoreseptor retina, lapisan sel ganglion, korpus siliaris, lensa, epitel dan endotel kornea, serta aquous humor, vitreous humor dan lapisan air mata. Defisiensi vitamin D dikatakan mempunyai kontribusi dalam DES, namun ada penelitian lain menyatakan tidak ada hubungan kadar vitamin D serum dengan DES. Atas dasar hal tersebut, maka tujuan penelitian ini untuk meneliti hubungan kadar vitamin D dengan DES.
Metode Penelitian ini merupakan penelitian observasional analitik dengan design crosssectional yang diikuti oleh karyawan FK USAKTI yang dilakukan pada bulan Februari – Maret 2021. Sebanyak 57 subjek berusia 25-60 tahun sesuai kriteria dan bersedia mengikuti penelitian ini. Pemeriksaan DES dilakukan dengan kuesioner OSDI, tes Schimer dan tear break-up time (TBUT). Pemeriksaan vitamin D dengan cara mengukur kadar 25(OH)D. Analisis dengan uji chi-square dengan tingkat kemaknaan yang digunakan p < 0.05.
Hasil Pada pemeriksaan kadar vitamin D dengan penderita DES dengan tes Schimer ditemukan tidak berhubungan (p=0.948), dibandingkan pemeriksaan kadar vitamin D dengan TBUT ditemukan berhubungan bermakna (p=0.030), sedangkan dengan menggunakan kuesioner OSDI ditemukan tidak berhubungan (p=0.285).
Kesimpulan Terdapat hubungan bermakna antara kadar vitamin D dengan DES melalui pemeriksaan TBUT.
Relationship between Magnesium Intake and Handgrip Strength in Elderly
Authors: Putra Muhammad Iqbal Arigi , Herwana Elly 
Published: February 2024

Background
Elders experience an aging process that is marked by a decrease in muscle mass that can result in a decrease in overall muscle strength. Handgrip strength is a parameter used to assess maximum handgrip which can represent an overall muscle strength. Magnesium has a role for skeletal muscles and also affects muscle performance. This study aims to measure the relationship between magnesium intake and handgrip strength in the elderly.
Methods
This study is an observational analytical study with a cross-sectional design, involving elders aged  60 years in elderly nursing homes as the study subjects. Elders who were able to communicate actively were included and elders who had physical disability were excluded. The Semi Quantitative Food Frequency Questionnaire (FFQ) was used for assessing magnesium intake and handgrip strength was measured using a handgrip dynamometer. Data were analyzed with Chi-Square statistical test and Fisher’s Exact Test with a significance of < 0.05.
Results
A group of 71 elders participated in this study. The result of this study shows that subjects with sufficient magnesium intake amounted to 18 subjects (25.4%) and 53 (74.6%) with low magnesium intake. The distribution of subjects with sufficient handgrip strength amounted to 36 subjects (50.7%) and 35 (49.3%) with low handgrip strength. Statistical analysis shows that there is no significant relationship between magnesium intake and handgrip strength in elders (p=0.539; p>0.05), while sociodemographic factors of age and gender showed a significant relationship towards handgrip strength (p=0.012 and p=0.028; p<0.05).
Conclusions
There is no significant relationship between magnesium intake and handgrip strength in elders. Sociodemographic factors of age and gender showed significant relationships towards handgrip strength.
The Association of Laboratory Parameters with COVID-19 Severity in Pregnancy
Authors: Nirmalasari Rully Ayu , Surjadi Lily Marliany , Maharani Laksmi , Lisnawati Yuyun , Mangun Dhea 
Published: February 2024

Background
Pregnant women were one of the most susceptible groups because they are vulnerable to respiratory infection. They may get more severe symptoms due to their physiological changes during pregnancy including the immunological response. This study was performed to find whether there is an association between laboratory parameters (Hb, leukocytes, platelet, neutrophils, lymphocyte, monocyte, NLR, PLR and CRP) and the severity of Covid-19 infection in pregnant women.
Methods
This study is a retrospective cohort study using secondary data from patient’s medical records at Persahabatan General Hospital, Jakarta from March to June 2021.
Results
Pregnancy cases with COVID-19 in this study were in the mean of 29 year age. Most of them are in the third trimester of pregnancy. 80.5% from 67 patients have no- mild symptom while 19.5% have moderate to severe symptom. There are no difference in vital sign nor oxygen saturation at first admission. Lower level was found in the parameter of leukocyte, lymphocyte and monocyte. Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein increase as the degree of severity increase. The mean neutrophil in pregnant women with moderate to severe COVID-19 symptom was 80.49±7.47 while median NLR value was of 6.76 (2.73-18.71) .
Conclusions
Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein has associate significantly to severity symtomps of COVID-19 in pregnancy.
Study of bone mineral density in medical faculties and students of Tezpur medical college and hospital
Authors: Akram Washim , Das Chinmoy , Pegu Firoz , Saifuddin Ahmed 
Published: February 2024

To examine the prevalence of low bone mineral density among the faculties and students of Tezpur medical college and hospital Hospital based cross-sectional study. Study will be conducted in the department of orthopaedics, Tezpur medical college and hospital for a period of 1 year. All faculties and students above 18 years attending outpatient department of orthopaedics were included in the study. Mean T-score among health staffs is -1.4. Maximum people in health staff groups are osteopenic with T-score of -1 to -2.5 comprising of 42%. Mean T-score among students is -1.2 with majority students is normal with T-score comprising of 52%. 45 patients had severe established osteoporosis. It was found that most individual in osteoporotic group had age group above 45 years.Ultrasonography can predict hip fractures and vertebral fractures. People with low bone mass and fragility fractures have osteoporosis and should be treated.