bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaping harms awareness messaging: exploring young South Australians’ responses to vaping prevention campaign materials
Authors: Trigg Joshua , Ela Ola , Bowden Jacqueline , Bartram Ashlea , Cenko Clinton , Bonevski Billie 
Published: November 2023

Abstract
Nicotine vaping products (NVPs) pose health risks associated with nicotine dependence and increased likelihood of tobacco consumption. Despite having a secondary role in smoking cessation, recreational NVP use is increasing among younger people. Vaping prevention campaigns aim to influence views on the health risks of vaping. This study examined perceptions of Australian and international vaping prevention campaigns among 27 young South Australians aged 16–26 years who do and do not use NVPs, to inform targeting and framing of vaping risk messaging. Participants viewed example materials from three vaping prevention campaigns: ‘Epidemic’, ‘Do you know what you’re vaping’ and ‘Unveil what you inhale’. Focus groups and interviews assessed whether materials were easily understood, appropriate, relevant, credible and effective in health communication. Participants indicated that all campaigns would influence their thoughts and actions related to vaping. The ‘Do you know what you’re vaping’ campaign prompted thoughts about uncertainty about individual health risks, though participants did not indicate that this was enough to motivate vaping cessation. Participants considered the ‘Unveil’ campaign effective, with those who did not vape indicating they would click through to access resources, and those who did vape responding well to the ‘challenge’ aspect of the messaging. The ‘Epidemic’ campaign fear appeal did not clearly prompt change in vaping views or behaviours. Campaigns using a challenge approach may generate conversation about vaping harms, while fear appeals can be dismissed by younger audiences. Evidence-based short messages and the presentation of multiple versions of content were considered effective approaches.
Inflammatory Bowel Disease and the Risk of Anal Squamous Intraepithelial Lesions and Anal Cancer in Men Who Have Sex With Men
Authors: Field Justin , Fenton Cynthia , Zhang Li , Brickman Cristina , Mahadevan Uma 
Published: November 2023

Abstract

Background
The risk of anal cancer is increased in patients with human immunodeficiency virus (HIV), inflammatory bowel disease (IBD), and among men who have sex with men (MSM). High grade squamous intraepithelial lesions (HSILs) are precursor lesions to anal squamous cell carcinoma (SCC), and treatment of these lesions can decrease progression to anal SCC. This study aims to determine the prevalence of HSIL and anal cancer among MSM patients with and without IBD referred for anal cancer screening.

Methods
This is a retrospective study of all MSM patients seen at an anal squamous intraepithelial lesions (aSILs) and anal cancer screening specialty clinic. Data were manually and electronically collected from clinical documentation and pathology results for the primary outcomes of HSIL and anal cancer. Demographics, HIV status, IBD disease status, disease phenotype, and immunosuppressive medication use were collected through the electronic health record. Descriptive statistics were used.

Results
In all, 4623 patients were included for analysis. Among 57 MSM patients with IBD, 25 (43.9%) had a history of HSIL, and 2 (3.5%) had a history of anal cancer. Among 4618 MSM patients without IBD, 2417 (52.3%) had a history of HSIL, and 139 (3.0%) had a history of anal cancer (P = .744). Rates of HIV were 49.1% among MSM patients with IBD and 69.8% among MSM patients without IBD (P = .001). There remained no difference in prevalence of HSIL and anal cancer between groups when adjusting for HIV status. Among IBD patients, only 21.6% were referred for screening by their gastroenterologist.

Conclusions
Among MSM with and without IBD, both groups had an equally high prevalence of HSIL and anal SCC. Awareness of appropriate surveillance to identify aSIL in MSM patients with IBD is needed among gastroenterologists.
Development of a maturity matrix to assess organizational readiness of community pharmacies for implementation of guideline recommendations in diabetes care
Authors: Teichert Martina , Fujita Kenji , Braspenning Jozé 
Published: November 2023

Abstract

Objectives
Pharmaceutical care for people with diabetes mellitus type 2 (DMT2) has been described in professional guidelines. To apply their recommendations, organizational changes are needed. We aimed to describe, for the first time, the development of a maturity matrix for community pharmacy teams (MM-CP) to assess organizational readiness in implementing the guideline recommendations on pharmaceutical DMT2 care.

Methods
MM-CP development was conducted in a systematic consensus process with pharmacists from existing working groups. In three meetings with preparatory assignments, mutually exclusive domains were chosen for the DMT2 guideline implementation. After determining the growth steps, the resulting matrix cells were filled with examples of the organizational implementation activities. To explore the generalizability of domains and growth steps, two other working groups for “medication surveillance” and “multidose drug dispensing” guidelines were consulted.

Key findings
A five-by-five matrix was developed using the domains “personalized care,” “teamwork,” “information systems and data exchange,” “external collaboration,” and “education and research” on the horizontal axis, and the growth steps “being aware and motivated,” “being able to,” “performing, evaluating and improving,” and “innovating” on the vertical axis. The MM-CP cells were filled with examples to implement the core recommendations of the DMT2 guideline. The matrix is to be used by pharmacy teams as a formative instrument.

Conclusions
The MM-CP is ready for use by community pharmacy teams for self-assessing their organizational readiness. However, further research is required to evaluate its potential in stimulating targeted improvement during the implementation of the DMT2-guideline recommendations in community pharmacies.
Networks of Power in the Nineteenth Century: The Sampradaya, Princely States and Company Rule
Authors: Patel Shruti 
Published: November 2023

Abstract
This article reconsiders a religious institution in India during the early colonial era as a manifestation of regional influence, or a non-statist public force. Founded by Sahajanand Swami, the Hindu devotional (bhakti) community known as the Swaminarayan Sampradaya expanded in the area that is today Gujarat in western India. The community arose as a source of popular influence in a region that lacked a dominant state at this time. Its creation was forged in relation to local struggles for power and resources, involving princely states, Maratha and East India Company powers, Kathi chieftains, and broader social and cultural changes in the nineteenth century. Historically examining the process of community expansion in the region through aspects like patronage and cultural production, I argue that the sampradaya’s articulation of devotion internalized political acumen to navigate material realities successfully. Effectively, the modern articulation enabled adherents to broker power from diverse networks and strengthen the community’s complex, multifaceted authority in Gujarat.
Antioxidant effect of lactic acid bacteria in human bronchial epithelial cells exposed to cigarette smoke
Authors: Babic Mirjana , Veljovic Katarina , Popović Nikola , Golic Natasa , Radojkovic Dragica , Stankovic Marija 
Published: November 2023

Abstract

Aims
Chronic lung diseases are a major and increasing global health problem, commonly caused by cigarette smoke. We aimed to explore the antioxidant effects of lactic acid bacteria (LAB) against cigarette smoke in bronchial epithelial cells.

Methods and results
The antioxidant effects of 21 heat-killed (HK) LAB strains were tested in cigarette smoke-stimulated BEAS-2B cells and 3-D bronchospheres organoids. We showed that HK Lactiplantibacillus plantarum BGPKM22 possesses antioxidant activity against cigarette smoke, resistance to hydrogen peroxide, and free radical neutralizing activity. We demonstrated that HK BGPKM22 inhibited cigarette smoke-induced expression of the Aryl hydrocarbon receptor (AhR) and Nuclear factor erythroid 2 related factor 2 (Nrf2) genes. The cell-free supernatant (SN) of BGPKM22 fully confirmed the effects of HK BGPKM22.

Conclusions
For the first time, we revealed that HK and SN of Lactip. plantarum BGPKM22 possess antioxidant activity and modulate AhR and Nrf2 gene expression in bronchial epithelial cells exposed to cigarette smoke.
A multiplex real-time RT-PCR system to simultaneously diagnose 16 pathogens associated with swine respiratory disease
Authors: Goto Yusuke , Fukunari Kazuhiro , Tada Shigekatsu , Ichimura Satoki , Chiba Yuzumi , Suzuki Tohru 
Published: November 2023

Abstract

Aims
Swine respiratory disease (SRD) is a major disease complex in pigs that causes severe economic losses. SRD is associated with several intrinsic and extrinsic factors such as host health status, viruses, bacteria, and environmental factors. Particularly, it is known that many pathogens are associated with SRD to date, but most of the test to detect those pathogens can be normally investigated only one pathogen while taking time and labor. Therefore, it is desirable to develop rapidly and efficiently detectable methods those pathogens to minimize the damage caused by SRD.

Methods and results
We designed a multiplex real-time RT-PCR (RT-qPCR) system to diagnose simultaneously 16 pathogens, including nine viruses and seven bacteria associated with SRD, on the basis of single qPCR and RT-qPCR assays reported in previous studies. Multiplex RT-qPCR system we designed had the same ability to single RT-qPCR without significant differences in detection sensitivity for all target pathogens at minimum to maximum genomic levels. Moreover, the primers and probes used in this system had highly specificity because the sets had not been detected pathogens other than the target and its taxonomically related pathogens. Furthermore, our data demonstrated that this system would be useful to detect a causative pathogen in the diagnosis using oral fluid from healthy pigs and lung tissue from pigs with respiratory disorders collected in the field.

Conclusions
The rapid detection of infected animals from the herd using our system will contribute to infection control and prompt treatment in the field.
High-sensitivity neonatal urine drug testing has similar positivity rates to meconium for detecting in utero exposure to methamphetamine and cocaine
Authors: Brown Hannah M , Roper Stephen M , Dietzen Dennis J , Crews Bridgit O 
Published: November 2023

Abstract
Current guidelines recommend universal screening for substance use disorders in obstetric patients, and neonatal drug testing is also frequently performed. Meconium is often the preferred specimen type to detect neonatal drug exposure due to a longer window of detection compared to urine, but most laboratories send out meconium testing to specialized reference laboratories, which can delay results for several days or more. Here, we evaluate a rapid and definitive liquid chromatography–tandem mass spectrometry method for neonatal urine drug testing and compare results obtained using this method to paired meconium drug testing in 1,424 neonates for amphetamines, cocaine, cannabinoids, opiates, oxycodone and phencyclidine. Urine testing showed equivalent sensitivity to current meconium methods for detecting in utero exposure to amphetamines and cocaine.
Photographic characterisation of acidification-induced larval malformations in the European lobster Homarus gammarus (Linnaeus, 1758) (Decapoda: Astacidea: Nephropidae)
Authors: Ramesh Kirti , Svanberg Linda , Casties Isabel , Eriksson Susanne , Dupont Sam 
Published: November 2023

Abstract
Occurrence of developmental malformations is of interest since they potentially influence organismal performance and fitness. We report an increased incidence (⁓ 46 fold) of physical malformations in the larvae of the American lobster Homarus Gammarus (Linnaeus, 1758) in response to seawater acidification (–0.58 pH units relative to nominal pH 8.0). We observed three malformations under the influence of seawater acidification previously undescribed in lobster larvae: a flared carapace, twisted tail, and cross claw. Larvae reared under seawater acidification exhibit significantly lower survivorship (by ⁓14%) and the occurrence of a malformation decreases survivorship (12.7%). Larvae with four types of malformations did not progress through development to reach post-larval stages. Namely, these malformations were a flared carapace, curled carapace, twisted tail, and cross claw. Results from this study provide photographic documentation of various lobster larval malformations that ultimately affect individual success and can be applied for quality-control in hatcheries.
Antifungal activity and mechanism of action of natural product derivates as potential environmental disinfectants
Authors: Silva-Beltrán Norma Patricia , Boon Stephanie A , Ijaz M Khalid , McKinney Julie , Gerba Charles P 
Published: November 2023

Abstract

There have been a considerable number of antifungal studies that evaluated natural products (NPs), such as medicinal plants and their secondary metabolites, (phenolic compounds, alkaloids), essential oils, and propolis extracts. These studies have investigated natural antifungal substances for use as food preservatives, medicinal agents, or in agriculture as green pesticides because they represent an option of safe, low-impact, and environmentally friendly antifungal compounds; however, few have studied these NPs as an alternative to disinfection/sanitation for indoor air or environmental surfaces. This review summarizes recent studies on NPs as potential fungal disinfectants in different environments and provides information on the mechanisms of inactivation of these products by fungi. The explored mechanisms show that these NPs can interfere with ATP synthesis and Ca++ and K+ ion flow, mainly damaging the cell membrane and cell wall of fungi, respectively. Another mechanism is the reactive oxygen species effect that damages mitochondria and membranes. Inhibition of the overexpression of the efflux pump is another mechanism that involves damage to fungal proteins. Many NPs appear to have potential as indoor environmental disinfectants.

One-Sentence Summary
This review shows the latest advances in natural antifungals applied to different indoor environments. Fungi have generated increased tolerance to the mechanisms of traditional antifungals, so this review also explores the various mechanisms of action of various natural products to facilitate the implementation of technology.
TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
Authors: Yu Jiyeon , Zamani Ali , Goldsmith Jason R , Etwebi Zienab , Lee Chin Nien , Chen Youhai H , Sun Honghong 
Published: November 2023

Abstract
Tissue infiltration by circulating leukocytes via directed migration (also referred to as chemotaxis) is a common pathogenic mechanism of inflammatory diseases. G protein–coupled receptors (GPCRs) are essential for sensing chemokine gradients and directing the movement of leukocytes during immune responses. The tumor necrosis factor α-induced protein 8-like (TIPE or TNFAIP8L) family of proteins are newly described pilot proteins that control directed migration of murine leukocytes. However, how leukocytes integrate site-specific directional cues, such as chemokine gradients, and utilize GPCR and TIPE proteins to make directional decisions are not well understood. Using both gene knockdown and biochemical methods, we demonstrated here that 2 human TIPE family members, TNFAIP8 and TIPE2, were essential for directed migration of human CD4+ T cells. T cells deficient in both of these proteins completely lost their directionality. TNFAIP8 interacted with the Gαi subunit of heterotrimeric (α, β, γ) G proteins, whereas TIPE2 bound to PIP2 and PIP3 to spatiotemporally control immune cell migration. Using deletion and site-directed mutagenesis, we established that Gαi interacted with TNFAIP8 through its C-terminal amino acids, and that TIPE2 protein interacted with PIP2 and PIP3 through its positively charged amino acids on the α0 helix and at the grip-like entrance. We also discovered that TIPE protein membrane translocation (i.e. crucial for sensing chemokine gradients) was dependent on PIP2. Collectively, our work describes a new mechanistic paradigm for how human T cells integrate GPCR and phospholipid signaling pathways to control directed migration. These findings have implications for therapeutically targeting TIPE proteins in human inflammatory and autoimmune diseases.
Expression, clinicopathological significance, and prognostic potential of AMPK, p-AMPK, PGC-1α, and TFAM in astrocytomas
Authors: Wang Juan , Lou Lei , Li Dan , Wang Yuan , Jia Xin , Hao Xue , Liu Weina , Li Yuehong , Wu Wenxin , Hou Lianguo , Cui Jinfeng 
Published: November 2023

Abstract
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. Activation of AMPK enhances the expression of proliferator-activated receptor γ coactivator 1α (PGC1-α) and subsequently activates mitochondrial transcription factor A (TFAM) to regulate mitochondrial oxidative respiratory function. The possible functions of AMPK, p-AMPK, PGC-1α, and TFAM and their interactions in astrocytomas are not known. Here, the levels, clinicopathological characteristics, and prognostic potential of AMPK, p-AMPK, PGC-1α, and TFAM expression levels in astrocytomas were evaluated. The results showed that levels of AMPK, p-AMPK, PGC-1α, and TFAM expression was increased in astrocytomas. Strong correlations were observed between AMPK, p-AMPK, PGC-1α, and TFAM expression in patients with astrocytomas. The analysis indicated that the levels of AMPK, p-AMPK, PGC-1α, and TFAM were associated with the survival. AMPK levels, tumor grade, and age were independent prognostic factors predicting poor outcomes in patients with astrocytoma. Together, these results indicate that these 4 targets may play a crucial role in the progression and prognosis of human astrocytomas and that AMPK may represent a potential therapeutic target.
International sanctions enacted against Russia as overriding mandatory rules—on which foot should international arbitrators stand?
Authors: Chevalier Maxime 
Published: November 2023

Abstract
Over the last decades, the role of international arbitrators has evolved from dealing with purely private interests to promoting the rule of law worldwide and safeguarding the interests of the international community. Following the armed conflict in Ukraine, a plurality of States has enacted international sanctions against Russia, which are currently impacting the performance of many international contracts. This article analyses the enforcement of international sanctions by international arbitrators as a matter of overriding mandatory public policy rules. This article also draws a new perspective on the subject, by analysing it from two different yet complementary approaches. First, because national courts have supervisory powers at the post-award stage, the reasoning of international arbitrators may depend on whether such international sanctions are regarded as public policy rules within relevant national legal orders. Secondly, because international arbitral tribunals have no forum, their decision regarding the enforcement of international sanctions will depend on the existing legal theories of international arbitration. After comparing the different results under the territorial, multilocal, and transnational approaches, the author advocates for the enforcement of international sanctions against Russia as part of transnational public policy rules.
A Feasibility Randomized Trial Evaluating Safe Peds: A Virtual Reality Training Program to Teach Children When to Cross Streets Safely
Authors: Morrongiello Barbara A , Corbett Michael , Dodd Belle , Zolis Caroline 
Published: November 2023

Abstract

Objective
Injury as pedestrians is a leading contributor to childhood deaths. This study evaluated the effectiveness of Safe Peds, a fully immersive virtual reality training program to teach children when to cross street safely, with the focus on a number of foundational skills and practicing these in traffic situations of varying complexity.

Methods
Children 7–10 years old were randomly assigned to a control (N = 31) or intervention (N = 26) group. Eligibility criteria included English speaking and typically developing. Testing took place on campus. All children completed pre- and post-testing measures, with those in the intervention group receiving training in between. Training comprised 1 session with 3 phases for a total of up to 1.5 hr and was tailored to each child’s performance over trials. On each trial, children decided when to cross and fully executed this crossing, with measures automatically taken by the system as they did so.

Results
Negative binomial regression and analysis of covariance tests were applied, predicting post-test scores while controlling for pre-test scores, age, and sex. The intervention was effective in improving children’s street crossing skills, including stopping and checking skills (stop at the curb, look left/right/left, check for traffic before crossing the yellow line), and choosing safe inter-vehicle gaps. Children in the control group did not show significant improvements in any crossing skills.

Conclusions
The Safe Peds program effectively teaches children skills to support their deciding when to safely cross in a variety of traffic situations. Implications for pedestrian injury are discussed.
Sacral metastases in a patient with BRAF V600E+ papillary thyroid carcinoma
Authors: Bhethanabotla Rohith M , Mohan Suresh , Lin Derrick , Shah Prerak 
Published: November 2023

Abstract
Lack of consensus exists on an algorithm to screen for synchronous distant metastases in patients presenting with papillary thyroid carcinoma (PTC). A 68-year-old male presented with a 3 cm supraclavicular neck mass. Computed tomography (CT) scan revealed a 1.3 cm left thyroid lobe nodule and 3 cm left level 3 and 4 lymphadenopathy. Ultrasound-guided fine needle aspiration was positive for PTC. Patient underwent total thyroidectomy and lymph node dissection with molecular testing confirming BRAF V600E+ PTC. Six weeks post-operatively, he developed left hip pain and numbness. Magnetic resonance imaging (MRI) revealed a large sacral mass and multiple bony lesions confirmed to be osseous metastases. Given the relatively rapid report of hip pain after surgery, metastases were likely synchronous at presentation and may have been detected with earlier suspicion. Further investigation is necessary to systematically stratify risk of synchronous distant metastases in patients with metastatic PTC.
Unilateral proptosis: a rare presentation of metastatic prostate cancer
Authors: Sharma Gaurav , Wanis Michael 
Published: November 2023

Abstract
Prostate adenocarcinomas with metastatic cranial involvement are rare, with signs and symptoms overlapping with those of the primary base of the skull tumour. The diagnosis was made following a biopsy of the suspected lesions that indicated the possibility of a prostatic primary malignancy based on immunohistochemistry using prostate-specific membrane antigen and subsequently confirmed histologically. We report an unusual case of a 52-year-old male who presented with unilateral proptosis and no prior urological history. Cranial, pulmonary, and thoracolumbar spinal metastases were identified with radiological imaging. We describe the diagnostic evaluation and treatment, as well as outline the rare nature of this case of cranial metastasis of prostate cancer.