bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of body acupuncture for primary insomnia: protocol for a systematic review
Authors: Li Danyang , Wang Sitian , Pi Siqie , Cao Yan , Zhang Dechou , Wu Xiao , Li Sheng 
Published: February 2024

Abstract

Background
Primary insomnia is a common sleep disorder that can have negative effects on patients’ health and quality of life. While clinical randomized controlled trials have suggested that acupuncture is effective in treating primary insomnia, further validation is needed to compare the efficacy of body acupuncture with medication. Therefore, this protocol outlines a program to evaluate the efficacy and adverse effects of body acupuncture and medication for the treatment of primary insomnia.
Methods
A systematic search will be conducted across 8 bibliographic databases from their inception to March 1, 2024. The databases include Cochrane Library, MEDLINE (via PubMed), Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Chinese Biomedical Literature Database (CBM). Randomized controlled trials published in English or Chinese, comparing body acupuncture with pharmacological approaches for primary insomnia, will be included. The primary outcomes of the study will be sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) and clinical treatment effectiveness rate. Two reviewers will independently screen studies, extract data, and assess risk of bias. The quality of included literature will be evaluated according to the Cochrane Handbook of Risk of Bias. Meta-analysis will be conducted using Review Manager 5.4 software.
Systematic review registration
The protocol has been registered at PROSPERO(https://www.crd.york.ac.uk/PROSPERO/ )with a registration number https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024504740
Discussion
The findings of this study will provide credible evidence to evaluate the efficacy and safety of body acupuncture and medication in treating patients with primary insomnia.
Removal of heavy metals from wastewater using 2D MXenes: A theoretical study
Authors: Wu Xin 
Published: February 2024

Abstract
Water is an indispensable material for human life. Unfortunately, the developments of industrial activities have reduced the quality of water resources in the world. Meantime, heavy metals are an important factor in water pollution due to their toxicity. This study highlights the method for the capture of heavy metal ions from wastewater using the procedure of adsorption. The adsorption of toxic heavy metal ions (Pb2+, Hg2+, and Cd2+) on Ca2C and Cr2C MXene monolayers is investigated using the density functional theory. We have optimized the considered MXenes by nine DFT functionals: PBE, TPSS, BP86, B3LYP, TPSSh, PBE0, CAM-B3LYP, M11, and LC-WPBE. Our results have shown a good agreement with previously measured electronic properties of the Ca2C and Cr2C MXene layers and PBE DFT method. The calculated cohesive energy for the Ca2C and Cr2C MXene monolayers are − 4.12 eV and − 4.20 eV, respectively, which are in agreement with the previous studies. The results reveal that the adsorbed heavy metal ions have a substantial effect on the electronic properties of the considered MXene monolayers. Besides, our calculations show that the metal/MXene structures with higher electron transport rates display higher binding energy and charge transfers between the metal and Ca2C and Cr2C layers. Time-dependent density functional analysis also displayed “ligand to metal charge transfer” excitations for the metal/MXene systems. The larger Ebin for the Pb@Ca2C as well as Pb@Cr2C are according to larger redshifts which are expected (∆λ = 45 nm and 71 nm, respectively). Our results might be helpful for future research toward the application of MXene-based materials for removing wastewater pollutants.
miR-1, miR-133a, and miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia.
Authors: Keane Alan J , Sanz-Nogués Clara , Jayasooriya Dulan , Creane Micahel , Chen Xiche , Lyons Caomhán J , Sikri Isha , Goljanek-Whysall Katarzyna , O'Brien Timothy 
Published: February 2024

Abstract
Background. Chronic limb-threatening ischaemia (CLTI) is the most severe manifestation of peripheral arterial disease (PAD), and is associated with poor prognosis and high amputation rates. Novel therapeutic approaches are currently being investigated, but to date, they have not demonstrated significant benefits in promoting CLTI limb salvage. Understanding the molecular pathways of skeletal muscle dysfunction in CLTI is imperative for a rational design of successful therapeutic approaches. The full spectrum of dysregulated microRNAs (miRNAs) associated with PAD disease stages is currently poorly understood. The purpose of this study was to identify dysregulated miRNA transcripts in gastrocnemius muscle biopsies that were differentially expressed in different PAD cohorts.
Methods. We performed an analysis of a publicly available RNA-sequencing database of PAD cohorts using MIcroRNA ENrichment TURned NETwork(MIENTURNET), a web tool for miRNA-target enrichment and network-based analysis. Following this, we validated the dysregulation of miRNAs and their targets in mice with hindlimb ischaemia (HLI).
Results. Our miRNA-target interaction enrichment analysis identified a list of miRNAs over-represented amongst upregulated differentially expressed genes (DEGs) in CLTI. Upon validation in the HLI model, our results showed a significant and marked ischaemia-induced decrease of miR-1, miR-133a, and miR-29b in the ischaemic limbs vs the contralateral non-ischaemic limbs. A miR-1, miR-133a, and miR-29b target protein-protein interaction network identified many extracellular matrix components including collagen-1a1, -3a1 and -4a1, fibronectin-1, fibrin-1, matrix metalloproteinase-2 and -14, and the secreted protein acidic and rich in cysteine (Sparc), which were upregulated in the ischaemic muscle in mice. Functional enrichment analysis performed on this subset of DEGs identified pathways related to fibrosis and vascular pathology.
Conclusions. We have identified, for the first time, a CLTI-specific miRNA signature. Our results indicate miR-1, miR-133a, and miR-29b as potential contributors to the fibrosis and vascular pathology in CLTI muscle, which supports its investigation as potential novel therapeutics.
Global green finance: deaths from air pollution and democracy index
Authors: Lucchetta Marcella 
Published: February 2024

Abstract
The condition of our planet's environment is deteriorating, which is creating difficulties for all living beings on Earth. However, there is potential for many prosperous nations to take more action to fight against climate change, as suggested by Lucchetta in 2023. It's worth questioning why the implementation of climate policies is not being expedited. This study indicates that: a) the level of democracy in a country has a negative correlation with green investments, which implies that it plays a significant role (Farzin and Bond 2006); b) investing in green bonds can reduce deaths caused by CO2 emissions; c) the study provides statistics and comparisons between China, USA, Europe, and Arab countries.

The methology utilized unbalanced panel data from 1985 to the present for the United States and Europe and from 1990 onwards for the United Arab Emirates and China. The data was analyzed using the Generalized Least Square (GLS) method.
On the Topology $\tau_{R}^{\diamond}$ of Primal Topological Spaces
Authors: ÖZKOÇ Murad , KÖSTEL Büşra 
Published: February 2024

Abstract
The main purpose of this paper is to introduce and study two new operators $(\cdot)_{R}^{\diamond}$ and $cl_{R}^{\diamond}(\cdot)$ via primal which is a new notion. We also show that the operator $cl_{R}^{\diamond}(\cdot)$ is a Kuratowski closure operator, while the operator $(\cdot)_{R}^{\diamond}$ is not. In addition, we prove that the topology on $X$, shown as $\tau_{R}^{\diamond}$, obtained by means of the operator $cl_{R}^{\diamond}(\cdot)$ is finer than $\tau_{\delta}$, where $\tau_{\delta}$ is the family of $\delta$-open subsets of a space $(X,\tau)$. Moreover, we not only obtain a base for the topology $\tau_{R}^{\diamond}$ but also prove many fundamental results concerning this new structure. Furthermore, we give many counterexamples related to our results.
2020 AMS Classifications: 54A05; 54B99; 54C60.
Новая коронавирусная инфекция COVID-19 у пациентов с волосатоклеточным лейкозом
Authors: Пластинина Любовь Васильевна , Аль-Ради Л. С. , Моисеева Т. Н. , Костина И. Э. , Чабаева Ю. А. , Барях Е. А. , Желнова Е. И. , Туполева Т. А. 
Published: February 2024

Aim. To analyze the characteristics of novel coronavirus infection COVID-19 in hairy cell leukemia (HCL) patients and to assess humoral immune response in those of them who had COVID-19 and/or were vaccinated against SARS-CoV-2.
Materials & Methods. This paper documents the retrospective analysis of the data from 118 HCL patients followed-up at the National Research Center for Hematology from March 2020 to October 2021. Within this period, 99 out of 118 patients had novel coronavirus infection COVID-19; 17 out of 99 COVID-19 patients were vaccinated against SARS-CoV-2 (3 of them prior to being infected and 14 of them after that). The rest of 19 HCL patients without COVID-19 were vaccinated against SARS-CoV-2 during the period from January to October 2021. By the time of HCL diagnosis, the patients were aged 23–74 years (median 47 years), whereas by the time of COVID-19 diagnosis, the age range was 25–82 years (median 55 years). There were 63 men and 36 women.
Results. Severe CT 3–4 lung lesions were diagnosed in 22 (22 %) patients and detected more often (55 %) prior to therapy for advanced-stage HCL. In patients on therapy for advanced-stage HCL and those in remission, the rate of severe lung lesions (CT 3–4) was 17 % in each group. COVID-19 therapy was administered to 49 (49 %) patients in a special hospital. Mortality in the total cohort was 6 % (n = 6) and differed in patients with advanced-stage HCL (n = 4) and those in remission (n = 2). The patients who received anti-CD20 monoclonal antibodies for < 12 months prior to COVID-19 infection, in 42 % (n = 5) of cases showed seronegativity vs. 5 % (n = 1) of patients who received the same therapy > 12 months before COVID-19 was diagnosed.
Conclusion. The most severe COVID-19 was observed in chemotherapy-free patients with advanced-stage HCL compared to patients on therapy or in HCL remission. When anti-CD20 monoclonal antibodies were administered for < 12 months prior to COVID-19 diagnosis, the number of patients with negative anti-SARS-CoV-2-IgG immune response increased 15-fold. Mortality in novel coronavirus infection COVID-19 differed at various HCL stages (in remission and at advanced stage).
CREB: A Promising Therapeutic Target for Treating Psychiatric Disorders
Authors: Guan Wei , Ni Mei-Xin , Gu Hai-Juan , Yang Yang 
Published: February 2024

:
Psychiatric disorders are complex, multifactorial illnesses. It is challenging for us to understand the underlying mechanism of psychiatric disorders. In recent years, the morbidity of psychiatric
disorders has increased yearly, causing huge economic losses to the society. Although some progress,
such as psychotherapy drugs and electroconvulsive therapy, has been made in the treatment of psychiatric disorders, including depression, anxiety, bipolar disorder, obsessive-compulsive and autism spectrum disorders, antidepressants and psychotropic drugs have the characteristics of negative effects and
high rate of relapse. Therefore, researchers continue to seek suitable interventions. cAMP response element binding protein (CREB) belongs to a protein family and is widely distributed in the majority of
brain cells that function as a transcription factor. It has been demonstrated that CREB plays an important role in neurogenesis, synaptic plasticity, and neuronal growth. This review provides a 10-year
update of the 2013 systematic review on the multidimensional roles of CREB-mediated transcriptional
signaling in psychiatric disorders. We also summarize the classification of psychiatric disorders and
elucidate the involvement of CREB and related downstream signalling pathways in psychiatric disorders. Importantly, we analyse the CREB-related signal pathways involving antidepressants and antipsychotics to relieve the pathological process of psychiatric disorders. This review emphasizes that
CREB signalling may have a vast potential to treat psychiatric disorders like depression. Furthermore,
it would be helpful for the development of potential medicine to make up for the imperfection of current antidepressants and antipsychotics.
The Use of Medical Services for Low-Acuity Emergency Cases in Germany: Protocol for a Multicenter Observational Pilot Study
Authors: Nau Lara Maria , Laux Gunter , Altiner Attila , Szecsenyi Joachim , Leutgeb Rüdiger 
Published: February 2024

Background
The increasing number of requests for help for acutely ill patients and their management is a major problem in the health systems of many countries, but especially in Germany. Rescue coordination centers and ambulances in Germany are increasingly overloaded. As a result, rides as a part of rescue operations have been increasing in length for years, yet a relevant proportion of these operations represent low-acuity calls (LACs). The basic objective of this pilot study is the quantitative analysis of the potential misuse of requests to the rescue control center. Indications for alternative treatment options and how to handle these treatment options in nonacute, non–life-threatening health conditions, such as minor injuries or minor infectious diseases, will be assessed. The identification of these LACs is vital in order to prevent health care resources in emergency medical care becoming inadequate.

Objective
The overarching goal of this study is to determine the percentage of unnecessary rescue missions on site and subsequently to obtain an impression of the paramedics’ assessment of alternative treatment options or alternative methods of rescue transportation.

Methods
This will be an exploratory, noninterventional, cross-sectional study with a quantitative approach. The study is multicentric, with 21 ambulances in 12 different locations. The data for this study were collected via a questionnaire, newly developed for this study, for rescue personnel. Additionally, secondary data from the responsible control center will be linked and processed in an initial descriptive analysis. This descriptive analysis will form the basis for a subsequent variance analysis.

Results
Data collection started as projected on September 18, 2023, and was ongoing until end of November 2023. We expect the documentation of several thousand rescue operations. We expect the following study results: (1) many unnecessary rescue operations, (2) immediate on-site assessment of correct care and treatment, and (3) patients’ reasons for calling a rescue coordination center.

Conclusions
To our knowledge, this is the first observational study in which acute rescue operations are recorded on site. The focus of this study is on the trained paramedics’ assessment of whether rescue operations are necessary or not. Additionally, alternative treatments, such as out-of-hours care service or primary care service, are shown for each individual case. The study also intends to cover the question of which factors are relevant and statistically significantly connected to the misuse of ambulances.

Trial Registration
German Register for Clinical Studies (Deutsches Register für Klinische Studien) DRKS00032510; https://drks.de/search/en/trial/DRKS00032510

International Registered Report Identifier (IRRID)
DERR1-10.2196/54002
Developing a Multiprofessional Mobile App to Enhance Health Habits in Older Adults: User-Centered Approach
Authors: Sobrinho Andressa Crystine da Silva , Gomes Grace Angelica de Oliveira , Bueno Júnior Carlos Roberto 
Published: February 2024

Background
Although comprehensive lifestyle habits are crucial for healthy aging, their adherence tends to decline as individuals grow older. Sustaining a healthy life over time poses a motivational challenge. Some digital tools, such as smartphone apps aimed at promoting healthy habits, have been used to counteract this decline. However, a more profound investigation is necessary into the diverse experiences of users, particularly when it concerns older adults or those who are unfamiliar with information and communications technologies.

Objective
We aimed to develop a mobile app focused on promoting the health of older adults based on the principles of software engineering and a user-centered design. The project respected all ethical guidelines and involved the participation of older adults at various stages of the development of the app.

Methods
This study used a mixed methods approach, combining both quantitative and qualitative methodologies for data collection. The study was conducted in Ribeirão Prêto, São Paulo, Brazil, and involved 20 older adults of both genders who were aged ≥60 years and enrolled in the Physical Education Program for the Elderly at the University of São Paulo. The research unfolded in multiple phases, encompassing the development and refinement of the app with active engagement from the participants.

Results
A total of 20 participants used a mobile health app with an average age of 64.8 (SD 2.7) years. Most participants had a high school education, middle-class status, and varying health literacy (mean score 73.55, SD 26.70). Overall, 90% (18/20) of the participants owned smartphones. However, 20% (4/20) of the participants faced installation challenges and 30% (6/20) struggled with web-based searches. The focus groups assessed app usability and satisfaction. Adjustments increased satisfaction scores significantly (Suitability Assessment of Materials: 34.89% to 70.65%; System Usability Scale: 71.23 to 87.14). Participant feedback emphasized font size, navigation, visual feedback, and personalization, and suggestions included health device integration, social interaction, and in-app communication support.

Conclusions
This study contributes to the development of health care technologies tailored to the older adult population, considering their specific needs. It is anticipated that the resulting app will serve as a valuable tool for promoting healthy habits and enhancing the quality of life for older adults.
Trends in Automated Peritoneal Dialysis Prescriptions in a Large Dialysis Organization in the United States
Authors: Giles Harold E. , Parameswaran Vidhya , Lasky Rachel , Ficociello Linda H. , Mullon Claudy , Chatoth Dinesh K. , Kraus Michael , Anger Michael S. 
Published: February 2024

Key Points

This is the largest analysis of incident automated peritoneal dialysis (PD) prescriptions conducted in the United States to date.There was limited variability of automated PD prescriptions across the first 4 months of therapy.PD prescriptions tailored to meet the dialysis needs and lifestyle of patients may make PD a more attractive choice and increase longevity on PD.

Background
Changes in health care policies and recognition of patient benefit have contributed to increases in home-based dialysis, including peritoneal dialysis (PD). Frequent monitoring and early individualization of PD prescriptions are key prerequisites for the delivery of high-quality PD. The present analysis aimed to assess variations in PD prescriptions among incident automated PD (APD) patients who remain on PD for 120+ days.

Methods
This retrospective analysis examined data from patients within a large dialysis organization that initiated PD with APD between 2015 and 2019. PD prescription data were described by calendar year, timing of PD, and residual renal function categories. Changes in prescriptions from PD initiation (day 1) to day 120 were assessed descriptively.

Results
The cohort included 11,659 patients. The mean age at PD initiation increased from 2015 (56 [15] years) through 2019 (58 [15] years), whereas most other variables demonstrated no clear temporal change. Most patients (86%) had nighttime PD prescribed, with an average of 4.9 (1.3) cycles per day, a mean total treatment volume of 9.3 (2.5) L, and a median daily total dwell time of 7 (6–9.5) hours. Relative to day 1 nighttime prescriptions, there were (1) small increases in the proportion of patients receiving three or fewer cycles per day and those receiving 6+ cycles per day, (2) a 100 ml mean increase in fill volume per exchange, and (3) a mean 0.5 L increase in total nighttime treatment volume at day 120. When changes in nighttime APD prescriptions were examined at the patient level, 49% of patients had day 120 prescriptions that were unchanged from their initial prescription.

Conclusions
In the largest analysis of incident APD prescriptions conducted in the United States to date, most patients were prescribed nocturnal PD only with limited variability across the first 4 months of therapy.
Management of Patients with Oral Lesions Associated Systemic Lupus Erythematous (SLE) Nephritis: A Case Report
Authors: Nur’aeny Nanan , Harmiyati Rahmi 
Published: February 2024

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease involving multi-organ such as mucocutaneous, musculoskeletal, and blood vessels with varied extraoral and intraoral clinical manifestations that require treatment from many medical specialists including dentists. The purpose of writing a case report is to describe how to manage oral lesions in patients with SLE Nephritis.
Case report: A female 17 years old patient was referred to the oral medicine department of Dr. Hasan Sadikin General Hospital from the pediatrics department and was diagnosed with SLE nephritis due to complaints of ulcers on almost the entire oral mucosa. Extraoral examination revealed a moon face, malar rash, and erythematous rash on the palms of the hands. Intraoral examination revealed multiple ulcers, on labial mucosa, buccal mucosa, lateral right of the tongue, palate, and white plaque on the dorsum of the tongue. The therapy provided was non-pharmacological and pharmacological. Non-pharmacological therapies include oral hygiene instruction and communication, information, education. Pharmacological therapy is a solution containing sucralfate and prednisone which is gargled for one minute, then followed by nystatin oral suspension drug that discards after one minute, then followed by chlorhexidine digluconate 0,12% mouthwash, gargle for one minute, as an antiseptic (each drug is applied in 0,5 – 1 hours). The patient has received a systemic corticosteroid drug (methylprednisolone), but the treatment of oral lesions requires additional topical corticosteroids to accelerate the healing process because of its direct effect on the mucosa.
Conclusion: The management of oral lesions using topical corticosteroids in patients with SLE nephritis can help accelerate the healing process.
Keywords: Management, Oral Lesions, SLE nephritis