bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale
Authors: Li Shuo , Liao Chenlong , Yang Xiaosheng , Zhang Wenchuan 
Published: October 2023

BackgroundThe pathogenesis of concomitant continuous pain remains unclear and is worthy of further study. In this clinical study, we aimed to explore the potential role of a narrow foramen ovale in the development of concomitant continuous pain.MethodsA total of 108 patients with classical trigeminal neuralgia affecting the third branch of the trigeminal nerve and 46 healthy individuals were enrolled in this study. Three-dimensional reconstructed computerized tomography images of all participants were collected, and the morphometric features of the foramen ovale were examined by two investigators who were blinded to the clinical data of the patients.ResultsIn this cohort, patients with concomitant continuous pain suffered from more sensory abnormalities (18.4% vs. 2.9%, p = 0.015) and responded more poorly to medication (74.3% vs. 91.9%, p = 0.018) than patients without concomitant continuous pain. While no significant differences regarding the mean length (5.02 mm vs. 5.36 mm, p &gt; 0.05) and area (22.14 mm2 vs. 23.80 mm2, p &gt; 0.05) were observed between patients with and without concomitant continuous pain, the mean width of the foramen ovale on the affected side in patients with concomitant continuous pain was significantly narrower than that in patients without concomitant continuous pain (2.01 mm vs. 2.48 mm, p = 0.003).ConclusionThis neuroimaging and clinical study demonstrated that the development of concomitant continuous pain was caused by the compression of the trigeminal nerve owing to a narrow foramen ovale rather than responsible vessels in classical trigeminal neuralgia.
Association between tea drinking and disability levels in older Chinese adults: a longitudinal analysis
Authors: Ma Yinghui , Zhu Yuying , Hong Dandan , Zhao Haiyue , Li Lei 
Published: October 2023

ObjectiveAs the global population ages, disability among the elderly presents unprecedented challenges for healthcare systems. However, limited research has examined whether dietary interventions like tea consumption may alleviate and prevent disability in older adults. As an important dietary therapy, the health benefits of tea drinking have gained recognition across research disciplines. Therefore, this study aimed to investigate the association between tea drinking habits and disability levels in the elderly Chinese population.MethodsLeveraging data from the 2008 to 2018 waves of the Chinese Longitudinal Healthy Longevity Survey, we disaggregated tea drinking frequency and activities of daily living (ADL) measures and deployed fixed-effect ordered logit models to examine the tea-disability association for the first time. We statistically adjusted for potential confounders and conducted stratified analyses to assess heterogeneity across subpopulations.ResultsMultivariable fixed-effect ordered logistic regression suggested tea drinking has protective effects against ADL disability. However, only daily tea drinking was associated with lower risks of basic activities of daily living (BADL) disability [odds ratio (OR) = 0.61; 95% confidence interval (CI), 0.41–0.92] and lower levels of instrumental activities of daily living (IADL) disability (OR = 0.78; 95% CI, 0.64–0.95). Stratified analyses indicated heterogeneous effects across age and income groups. Daily tea drinking protected against BADL (OR = 0.26 and OR = 0.28) and IADL disability (OR = 0.48 and OR = 0.45) for adults over 83 years old and high-income households, respectively.ConclusionWe found that drinking tea almost daily was protective against disability in elderly people, warranting further research into optimal dosages. Future studies should utilize more rigorous causal inference methods and control for confounders.
Paraneoplastic dermatomyositis associated with urothelial cancer: report of a case and systematic review of the literature
Authors: Sabaté-Ortega Josep , Bujons-Buscarons Elisabet , Fina-Planas Clàudia , Vilanova-Anducas Núria , Vidal-Sarró Noemí , Sala-González Núria 
Published: October 2023

BackgroundThe idiopathic inflammatory myopathies (IIM) are a collection of autoimmune diseases that have a substantial impact on the entire body and include conditions such as dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis, and immune-mediated necrotizing myopathy. These disorders are characterized by symptoms such as muscular weakness, pain, and dermal rash. This systematic review is intended to explore the potential link between bladder cancer and DM/PM.MethodsWe performed a comprehensive systematic search on PubMed and Scopus until August 2022 to identify relevant research studies. The studies that met our inclusion criteria focused on patients with urinary bladder cancer and dermatomyositis, and/or polymyositis.ResultsThe patients’ median age was 65.5 years (47–79), with the majority being male (15, 39.47%). Bladder cancer manifested before PM/DM in 5 (13.15%) patients, while in the majority of cases occurred after the cancer diagnosis. The stage of cancer at the time of the initial PM/DM diagnosis were mostly locally (11/20, 50%).During the first presentation, the patients had a median creatine kinase level of 2227 U/L, ranging between 44 and 10471. In one case, anti-TIF-1γ antibodies were found to be present. Among the cases with reported medical history (20/38), treatment immediately improved DM symptoms in 16 patients(53.8%) and in 3 patients(15%), symptoms of DM resurfaced during the period after the operation. Death was reported in 14 (36.8%) patients.ConclusionIn conclusion, our study provides knowledge and understanding for identifying specific risk factors in patients with the coexistence of bladder cancer and DM/PM and their management. During the initial and follow-up screening, age, gender, and the clinicopathological subgroup of myositis should be considered to ensure proper management of the condition.
Neuropsychiatric adverse drug reactions with oral tyrosine kinase inhibitors in metastatic colorectal cancer: an analysis from the FDA Adverse Event Reporting System
Authors: Barbieri Maria Antonietta , Russo Giulia , Sorbara Emanuela Elisa , Cicala Giuseppe , Franchina Tindara , Santarpia Mariacarmela , Speranza Desirèe , Spina Edoardo , Silvestris Nicola 
Published: October 2023

IntroductionNew oral tyrosine kinase inhibitors (TKIs) are approved for metastatic colorectal cancer (mCRC). The aim of this study was to assess the neuropsychiatric adverse drug reactions (ADRs) of these drugs reported in the FDA Adverse Event Reporting System (FAERS) database.MethodsAll reports with regorafenib (REG) and encorafenib (ENC) as the primary suspect, and reported in the FAERS between 2012 and 2022, were collected. A descriptive and disproportionality analyses were conducted.ResultsOut of 4,984 cases, 1,357 (30.2%) reported at least one neuropsychiatric ADR. New potential signals for REG included neuropathy peripheral (n = 265; reporting odds ratio, ROR = 19.48, 95% confidence interval, CI 95% = 17.52-22.47; information component, IC = 2.89, IC025-IC075 = 2.77-3.02), hyperesthesia (n = 18; ROR = 12.56, CI 95% = 7.90-19.96; IC = 2.25, IC025-IC075 = 1.79-2.72), taste disorder (n = 41; ROR = 9.91, CI 95% = 7.29-13.49; IC = 2.18, IC025-IC075 = 1.88-2.49), poor quality sleep (n = 18; ROR = 6.56, CI 95% = 4.13-10.42; IC = 1.74, IC025-IC075 = 1.27-2.20), altered state of consciousness (n = 15; ROR = 5.50, CI 95% = 3.31-9.14; IC = 1.57, IC025-IC075 = 1.06-2.07), depressed mood (n = 13; ROR = 1.85, CI 95% = 1.07-3.19; IC = 0.58, IC025-IC075 = 0.04-1.13) and insomnia (n = 63; ROR = 1.48, CI 95% = 1.15-1.89; IC = 0.38, IC025-IC075 = 0.13-0.63). For ENC comprised depressed mood (n = 4; ROR = 5.75, CI 95% = 2.15-15.39; IC = 1.74, IC025-IC075 = 0.76-2.73) and cognitive disorders (n = 3; ROR = 4.71, CI 95% = 1.51-14.66; IC = 1.54, IC025-IC075 = 0.41-2.68).DiscussionThis study identified new unknown potential neuropsychiatric ADRs. Further investigations are required to better define the neurotoxicity of TKIs in mCRC patients.
Efficacy of the visual cognitive assessment test for mild cognitive impairment/mild dementia diagnosis: a meta-analysis
Authors: Hsu Jui-Hung , Liu Chien-Cheng , Chen I-Wen , Wu Jheng-Yan , Huang Po-Yu , Liu Ting-Hui , Hung Kuo-Chuan 
Published: October 2023

BackgroundMild cognitive impairment (MCI) is an intermediate stage between normal ageing and dementia. The early identification of MCI is important for timely intervention. The visual cognitive assessment test (VCAT) is a brief language-neutral screening tool for detecting MCI/mild dementia. This meta-analysis evaluated the diagnostic efficacy of the VCAT for MCI/mild dementia.MethodsMedline, Embase, Google Scholar, and Cochrane Library were searched from their inception until August 2023 to identify studies using VCAT to diagnose MCI/mild dementia. The primary outcome was to assess the diagnostic accuracy of the VCAT for detecting MCI/mild dementia through area under the receiver operating characteristic curve (AU-ROC) analysis. The secondary outcome was to explore the correlation between VCAT scores and MCI/mild dementia presence by comparing scores among patients with and without MCI/mild dementia. Pooled sensitivity, specificity, and area under the curve (AUC) were calculated.ResultsFive studies with 1,446 older adults (mean age 64–68.3 years) were included. The percentage of participants with MCI/mild dementia versus controls ranged from 16.5% to 87% across studies. All studies were conducted in Asian populations, mostly Chinese, in Singapore and Malaysia. The pooled sensitivity was 80% [95% confidence interval (CI) 68%–88%] and the specificity was 75% (95% CI 68%–80%). The AU-ROCC was 0.77 (95% CI 0.73–0.81). Patients with MCI/mild dementia had lower VCAT scores than the controls (mean difference −6.85 points, p &lt; 0.00001).ConclusionVCAT demonstrated acceptable diagnostic accuracy in distinguishing MCI/mild dementia in cognitively normal older adults. As a language-neutral and culturally unbiased tool, the VCAT shows promise in detecting MCI/mild dementia. Further studies in non-Asian populations are required.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023453453.
Individuals with developmental disabilities make their own stylistic contributions to text written with physical facilitation
Authors: Nicoli Giovanni , Pavon Giulia , Grayson Andy , Emerson Anne , Cortelazzo Michele , Mitra Suvobrata 
Published: October 2023

IntroductionFor individuals with developmental disabilities (DD) such as autism, Down syndrome, or cerebral palsy, learning to express with language is a two-fold challenge because atypical cognitive capacity is compounded by sensorimotor coordination deficits. One approach to assisting linguistic expression in these individuals is to physically support them, for example, by touching their torso or arm as they type. The neurophysiological mechanism of such motor assistance for linguistic expression is not known, but recently it has been proposed that light touch may reduce the cognitive load associated with the sensorimotor coordination of typing, thereby releasing shared cognitive resources to the task of generating content. Historically, there has been significant controversy over the extent to which the facilitator and not the user authors texts written with touch assistance. User groups and a few researchers have argued that the user can express their thoughts through such techniques, but the prevailing view among researchers is that these texts are entirely the by-products of the facilitators' ideomotor cueing of users' movements. If the user is not a source of the produced text, the only linguistic style detectable in the text should be the facilitator's.MethodsHere, we use quantitative linguistic analysis to investigate whether DD users typing text with touch assistance exhibit their own stylistic signatures alongside those of their facilitators. In Study 1, we investigate whether the stylometric fingerprints of a set of users are detectable when they are all assisted by the same facilitator. In Study 2, we examine whether the users' stylometric characteristics are retained even when they are assisted by multiple facilitators.ResultsAcross both studies, the results show that the users' stylistic signature is detectable alongside that of facilitators. This suggests that the texts generated by DD users withphysical assistance should be viewed as coauthored rather than wholly authored by facilitators via ideomotor processes.DiscussionThe users' stylometric presence in these texts suggests that touch-assistance may serve as a developmental scaffold and should be re-appraised as a teaching aid even where unassisted linguistic expression is an unlikely end goal.
Comparison of web-based information about cell-free DNA prenatal screening: implications for differences of sex development care
Authors: Kim Soojin , Finney Esther L. , Naha Ushasi , Rosoklija Ilina , Honegger Kyle S. , Goetsch Weisman Allison , Holl Jane L. , Finlayson Courtney , Chen Diane , Johnson Emilie K. 
Published: October 2023

ObjectiveCell-free DNA (cfDNA) prenatal screening is a commercially available noninvasive test that detects fetal genetic material in maternal blood. While expectant parents often use it for “gender” determination, there is little information about unintended consequences of testing, such as revelation of a difference of sex development (DSD). The study aimed to characterize currently available website information about cfDNA and compare the cfDNA-related content.MethodsA systematic search for websites with information about cfDNA was conducted using search terms generated by a natural language processing analysis of the results of an Amazon Mechanical Turk (MTurk) survey of 1,000 parents and then performing a “Google” search, using the terms. Commercial cfDNA testing companies (CC) websites were also identified by consulting a genetic counselor (AGW). Data were collected on about each website’s characteristics and information about cfDNA. Information about cfDNA was compared between websites. Data were analyzed using descriptive statistics, Fisher’s exact test or Kruskal-Wallis test were applied, as appropriate.ResultsSixty websites were identified. After eliminating duplicates, 11 commercial company (CC) websites were identified. Nineteen other websites were reviewed of which six overlapped with five CC websites. Most of the websites had non-professional authors (73.7%), such as laypersons and CC representatives. CC websites were significantly more likely than search term-identified websites to state that cfDNA can screen for trisomy 21 (p=0.002), trisomy 18 (p&lt;0.0001), trisomy 13 (p&lt;0.001), sex chromosome aneuploidies (p&lt;0.001), and microdeletions (p=0.002).ConclusionsThis study shows that most website currently available information for expectant parents about cfDNA prenatal screening is produced by non-professional organizations. There are significant differences between the information provided by CC and Google search websites, specifically about the number of conditions screened for by cfDNA. Improving availability and quality of information about cfDNA could improve counseling future expectant parents. Inclusion of information about the potential for detection of a DSD is needed.
Linking New Alleles at the Oscillator Loci to Flowering and Expansion of Asian Rice
Authors: Gao Guangtong , Chen Maoxian , Mo Rong , Li Nan , Xu Yunzhang , Lu Yingqing 
Published: October 2023

The central oscillator is believed to be the key mechanism by which plants adapt to new environments. However, impacts from hybridization, the natural environment, and human selection have rarely been assessed on the oscillator of a crop. Here, from clearly identified alleles at oscillator loci (OsCCA1/LHY, OsPRR95, OsPRR37, OsPRR59, and OsPRR1) in ten diverse genomes of Oryza sativa, additional accessions, and functional analysis, we show that rice’s oscillator was rebuilt primarily by new alleles from recombining parental sequences and subsequent 5′ or/and coding mutations. New alleles may exhibit altered transcript levels from that of a parental allele and are transcribed variably among genetic backgrounds and natural environments in RIL lines. Plants carrying more expressed OsCCA1_a and less transcribed OsPRR1_e flower early in the paddy field. 5′ mutations are instrumental in varied transcription, as shown by EMSA tests on one deletion at the 5′ region of highly transcribed OsPRR1_a. Compared to relatively balanced mutations at oscillator loci of Arabidopsis thaliana, 5′ mutations of OsPRR37 (and OsCCA1 to a less degree) were under negative selection while those of OsPRR1 alleles were under strong positive selection. Together, range expansion of Asian rice can be elucidated by human selection on OsPRR1 alleles via local flowering time-yield relationships.
HUBUNGAN PERILAKU CARING PERAWAT TERHADAP TINGKAT KECEMASAN PASIEN PREOPERASI DI RUANG MERAK RSAU DR. ESNAWAN ANTARIKSA
Authors: Rahayuningsih Sri , Fatimah Siti 
Published: October 2023

Menurut data dari WHO tahun 2012 jumlah pasien dengan tindakan operasi setiap tahun mengalami peningkatan. Perilaku caring perawat menjadi jaminan apakah layanan perawatan bermutu atau tidak. Kecemasan dapat terjadi pada pasien praoperasi, apabila tidak mendapat penanganan yang adekuat, tidak tertutup kemungkinan kecemasan akan bertambah parah yang berdampak kepada ketidaksiapan pasien menjalani operasi. Tujuan penelitian untuk menegtahui hubungan perilaku caring perawat dengan tingkat kecemasan pasien preoperasi di ruang Merak RSAU dr. Esnawan Antariksa. Metode Penelitian desain yang digunakan dalah deskriptif korelasi pendekatan cross sectional. Populasi adalah pasien yang akan dilakukan operasi di ruang Merak RSAU dr. Esnawan Antariksa Jakarta yang berjumlah 94 orang, pengambilan sampel menggunakan teknik purposive sampling sebanyak 44 responden. Hasil uji Chi Square pada Fisher’s Exact Test didapatkan bahwa nilai Asymptotic Significance (2-sided) adalah 0,044 (Nilai Asymp Sig< 0,05). Simpulan ada hubungan yang signifikan antara perilaku caring perawat dengan tingkat kecemasan pasien preoperasi di ruang Merak RSAU dr. Esnawan Antariksa. Saran mengadakan pendidikan dan pelatihan service exellent secara berkesinambungan dan untuk mengurangi kecemasan dengan aroma therapi, buku rohani dan terapi musik.

According to data from WHO in 2012 the number of patients with surgery every year has increased. Nurse caring behavior is a guarantee whether the quality of care services or not. Anxiety can occur in preoperative patients, if they do not get adequate treatment, it is possible that anxiety will get worse which impacts on the patient's unpreparedness to undergo surgery. The purpose of this study was to determine the relationship of nurses caring behavior with preoperative patient anxiety levels in the Peacock Room RSAU dr. Esnawan Space. The research method design used is descriptive cross sectional correlation approach. The population is the patient who will be operated on in the Merak Hospital RSAU dr. Esnawan Antariksa Jakarta, amounting to 94 people, sampling using a purposive sampling technique of 44 respondents. Results Chi Square test on the Fisher's Exact Test found that the value of Asymptotic Significance (2-sided) is 0.044 (Sig Asymp Value <0.05). Conclusion there is a significant relationship between nurses caring behavior with the anxiety level of preoperative patients in Merak Hospital RSAU dr. Esnawan Space. Suggestions are to carry out excellent education and service training on an ongoing basis and to reduce anxiety with the aroma of therapy, spiritual books and music therapy.
PENGGUNAAN ALAT PELINDUNG DIRI DENGAN KEJADIAN DERMATITIS KONTAK PADA PETANI DI KECAMATAN PAMIJAHAN BOGOR TAHUN 2019
Authors: Aina Qorry , Idris Muhamad 
Published: October 2023

Kelainan dan gangguan kesehatan yang terjadi akibat keracunan akut pada pestisida salah satunya berupa iritasi kulit dan mata. Dermatitis kontak merupakan dermatitis yang disebabkan oleh bahan atau substansi yang menempel pada kulit. Tujuan penelitian ini untuk mengetahui hubungan antara perilaku tentang penggunaan APD dengan kejadian dermatitis kontak pada petani di Kecamatan Pamijahan Bogor tahun 2019. Metode Penelitian menggunakan deskriptif korelatif dengan pendekatan cross sectional. Populasi berjumlah 73 orang. Analisis yang digunakan univariat dan bivariat, menggunakan chi-square dengan nilai α = 5%. Hasil Penelitian didapatkan variabel yang berhubungan dengan kejadian dermatitis kontak yaitu pengetahuan (p value=0,000), sikap (p value=0,001), dan tindakan (p value=0,000). Simpulan adanya hubungan yang signifikan antara perilaku tentang penggunaan APD dengan kejadian dermatitis kontak pada petani di Kecamatan Pamijahan Bogor tahun 2019. Saran perlu ditingkatkan penggunaan APD dengan lengkap pada saat menggunakan pestisida dimana APD sangat penting bagi petani pada saat mencampur pestisida hingga mencuci alat-alat aplikasi agar meminimalkan kejadian dermatitis kontak. Sebaiknya petani datang penyuluhan/pelatihan agar mengetahui bahaya pestisida.

Health disorders and disorders that occur due to acute poisoning of pesticides one of which is in the form of skin and eye irritation. Contact dermatitis is dermatitis that is caused by a substance or substance attached to the skin. The purpose of this study was to determine the relationship between behavior about the use of PPE with the incidence of contact dermatitis in farmers in Pamijahan Subdistrict, Bogor in 2019. The research method used descriptive correlative with cross sectional approach. The population is 73 people. The analysis used univariate and bivariate, using chi-square with a value of α = 5%. The results showed that variables related to the incidence of contact dermatitis were knowledge (p value = 0,000), attitude (p value = 0.001), and actions (p value = 0,000). Conclusion there is a significant relationship between behavior about the use of PPE with the incidence of contact dermatitis in farmers in Pamijahan Subdistrict, Bogor in 2019. Suggestions need to be improved in the use of PPE completely when using pesticides where PPE is very important for farmers when mixing pesticides to washing application tools in order to minimize the incidence of contact dermatitis. Farmers should come to counseling/training to know the dangers of pesticides.
HUBUNGAN TINGKAT STRES DENGAN GEJALA PSIKOPATOLOGI PADA PENERBANG MILITER TNI AU DI LAKESPRA SARYANTO
Authors: Idris Muhamad , Lusiyani Neng Lilis 
Published: October 2023

Penerbang militer bekerja pada lingkungan yang memiliki potensi sebagai stresor. Stresor didapatkan bukan hanya dari lingkungan pekerjaan melainkan dari faktor psikososial. Stresor bisa menyebabkan stres pada seseorang tergantung kognitif, kepribadian, dan mekanisme adaptasi seseorang menghadapi stresor tersebut. Tujuan Penelitian adalah untuk mengidentifikasi hubungan stres dengan gejala psikopatologi pada penerbang militer TNI AU di Lakespra Saryanto. Metode penelitian ini menggunakan desain deskripif korelatif dengan pendekatan cross sectional dan pengambilan sampel dengan teknik purposive sampling sebanyak 67 responden. Data variabel independen dan dependen yang diperoleh diolah menggunakan uji Chi Square dengan derajat kemaknaan (α)= 0,05. Hasil penghitungan distribusi frekuensi tingkat stres penerbang stres ringan 36 (53,7 %) dan stres berat 15 (22,4 %), Sedangkan penerbang yang mengalami gejala psikopatologi 28 (41,8 %) dan yang tidak mengalami gejala psikopatologi 39 (58,2%). Uji Chi Square didapatkan nilai P value (2-sided) adalah 0,296 (Nilai Asymp Sig < 0,05). Kesimpulan tidak ada hubungan antara stres penerbang dengan munculnya gejala psikopatologi pada penerbang militer TNI AU. Saran mengadakan pendidikan dan pelatihan managemen stres secara berkesinambungan bagi penerbang di Lakespra Saryanto.