bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accessibility of large events: an empirical study of the Expo 2020 Dubai
Authors: Jiménez-Andres María 
Published: January 2024

AbstractEvent management is a growing sector in the tourism industry and one of the fastest growing industries in the world. The sector contributes significantly to global economies and provides substantial employment opportunities. Events are spaces for social interaction, education, leisure and opportunities. More recently, interest is being placed in making events accessible, yet the emerging body of research on accessibility, inclusion and diversity in events is still scarce. The objective of this paper is to contribute to understanding the accessibility of large events in an increasingly technology-dependent industry. With this purpose in mind, an evaluation of the accessibility of the Expo 2020 in Dubai has been conducted. Expos are events that showcase the latest technologies and innovation, are attended by million visitors and have hefty budgets. These factors make these events the ideal breeding ground for the implementation of advanced technologies. The study adopts a case study approach and draws on data from observation, in-depth interviews and online, qualitative questionnaires. The participants are people with disabilities (PwDs), the organizations in charge of the accessibility of the Expo and staff that worked at the event—some of whom were also PwDs. The experiences of PwDs at the event, the accessibility provision in place and the challenges and insights of accessibility experts involved are discussed, as well as the implications and recommendations for managing the accessibility of large events.
Developing the Lung Graph-Based Machine Learning Model for Identification of Fibrotic Interstitial Lung Diseases
Authors: Sun Haishuang , Liu Min , Liu Anqi , Deng Mei , Yang Xiaoyan , Kang Han , Zhao Ling , Ren Yanhong , Xie Bingbing , Zhang Rongguo , Dai Huaping 
Published: January 2024

AbstractAccurate detection of fibrotic interstitial lung disease (f-ILD) is conducive to early intervention. Our aim was to develop a lung graph-based machine learning model to identify f-ILD. A total of 417 HRCTs from 279 patients with confirmed ILD (156 f-ILD and 123 non-f-ILD) were included in this study. A lung graph-based machine learning model based on HRCT was developed for aiding clinician to diagnose f-ILD. In this approach, local radiomics features were extracted from an automatically generated geometric atlas of the lung and used to build a series of specific lung graph models. Encoding these lung graphs, a lung descriptor was gained and became as a characterization of global radiomics feature distribution to diagnose f-ILD. The Weighted Ensemble model showed the best predictive performance in cross-validation. The classification accuracy of the model was significantly higher than that of the three radiologists at both the CT sequence level and the patient level. At the patient level, the diagnostic accuracy of the model versus radiologists A, B, and C was 0.986 (95% CI 0.959 to 1.000), 0.918 (95% CI 0.849 to 0.973), 0.822 (95% CI 0.726 to 0.904), and 0.904 (95% CI 0.836 to 0.973), respectively. There was a statistically significant difference in AUC values between the model and 3 physicians (p < 0.05). The lung graph-based machine learning model could identify f-ILD, and the diagnostic performance exceeded radiologists which could aid clinicians to assess ILD objectively.
Graphical Abstract

Given a sequence of HRCT slices from a patient, the lung field is first automatically extracted. Next, this lung region is divided into 36 sub-regions using geometric rules, obtaining a lung atlas. And then, the lung graph is built based on 3D radiomics features of each sub-region of the lung atlas. Finally, the model’s predictions were compared to the physicians’ assessment results.
Subjective Experiences of Pregnancy, Delivery, and Nursing in Transgender Men and Non-Binary Individuals: A Qualitative Analysis of Gender and Mental Health Concerns
Authors: Falck Felicitas A. O. K. , Dhejne Cecilia M. U. , Frisén Louise M. M. , Armuand Gabriela M. 
Published: January 2024

AbstractStudies of how gender-diverse individuals experience pregnancy, childbirth, and nursing remain few, mainly focus on the US and contain scarce information about mental health concerns peri-partum. This hinders informed reproductive health decisions and counseling. We used in-depth interviews to examine how gestational gender-diverse individuals in Sweden experience the process of planning and undergoing pregnancy, delivery, and nursing. In total, 12 participants, identifying on the masculine side of the gender spectrum or as non-binary, who had attended Swedish antenatal care and delivered a live birth, were included in the study. Data were analyzed using qualitative thematic content analysis. The analysis resulted in one overarching theme: sustaining gender congruence during pregnancy and three main categories: (1) considering pregnancy; (2) undergoing pregnancy and childbirth; and (3) postnatal reflections. The association between childbearing and being regarded as female permeated narratives. Participants renegotiated the feminine connotations of pregnancy, accessed gender-affirming treatment, and concealed their pregnancy to safeguard their gender congruence. Mis-gendering and breast enlargement triggered gender dysphoria. Social judgment, loneliness, information shortages, hormonal influence and cessation of testosterone increased gender dysphoria and strained their mental health. Depression exacerbated gender dysphoria and made it harder to claim one’s gender identity. Dissociation was used to handle a feminized body, vaginal delivery, and nursing. Pregnancy was easier to envision and handle after masculinizing gender-affirming treatments. The results deepen the understanding of gender dysphoria and may be used to inform reproductive counseling and healthcare development. Research outcomes on mental health concerns provide a basis for further research.
Assessing the importance of primary care diagnoses in the UK Biobank
Authors: Clifton Lei , Liu Xiaonan , Collister Jennifer A , Littlejohns Thomas J , Allen Naomi , Hunter David J 
Published: January 2024

AbstractThe UK Biobank has made general practitioner (GP) data (censoring date 2016–2017) available for approximately 45% of the cohort, whilst hospital inpatient and death registry (referred to as “HES/Death”) data are available cohort-wide through 2018–2022 depending on whether the data comes from England, Wales or Scotland. We assessed the importance of case ascertainment via different data sources in UKB for three diseases that are usually first diagnosed in primary care: Parkinson’s disease (PD), type 2 diabetes (T2D), and all-cause dementia. Including GP data at least doubled the number of incident cases in the subset of the cohort with primary care data (e.g. from 619 to 1390 for dementia). Among the 786 dementia cases that were only captured in the GP data before the GP censoring date, only 421 (54%) were subsequently recorded in HES. Therefore, estimates of the absolute incidence or risk-stratified incidence are misleadingly low when based only on the HES/Death data. For incident cases present in both HES/Death and GP data during the full follow-up period (i.e. until the HES censoring date), the median time difference between an incident diagnosis of dementia being recorded in GP and HES/Death was 2.25 years (i.e. recorded 2.25 years earlier in the GP records). Similar lag periods were also observed for PD (median 2.31 years earlier) and T2D (median 2.82 years earlier). For participants with an incident GP diagnosis, only 65.6% of dementia cases, 69.0% of PD cases, and 58.5% of T2D cases had their diagnosis recorded in HES/Death within 7 years since GP diagnosis. The effect estimates (hazard ratios, HR) of established risk factors for the three health outcomes mostly remain in the same direction and with a similar strength of association when cases are ascertained either using HES only or further adding GP data. The confidence intervals of the HR became narrower when adding GP data, due to the increased statistical power from the additional cases. In conclusion, it is desirable to extend both the coverage and follow-up period of GP data to allow researchers to maximise case ascertainment of chronic health conditions in the UK.
Revisiting the Geochemical Classification of Zircon Source Rocks Using a Machine Learning Approach
Authors: Itano Keita , Sawada Hikaru 
Published: January 2024

AbstractTrace element fingerprints preserved in zircons offer clues to their origin and crystallization conditions. Numerous geochemical indicators have been established to evaluate the source rock characteristics from a geochemical perspective; however, multivariate trace element data have not been sufficiently investigated statistically. As substantial amounts of zircon data from a wide range of rock types have become accessible over the past few decades, it is now essential to reassess the utility of trace elements in discriminating source rock types. We employed a new zircon trace element dataset and established classification models to distinguish eight types of source rocks: igneous (acidic, intermediate, basic, kimberlite, carbonatite, and nepheline syenite), metamorphic, and hydrothermal. Whereas a conventional decision tree analysis was unable to correctly classify the new dataset, the random forest and support vector machine algorithms achieved high-precision classifications (> 80% precision, recall, and F1 score). This work confirms that trace element composition is a helpful tool for province studies and mineral exploration using detrital zircons. However, the compiled dataset with many missing values leaves room for improving the models. Trace elements, such as P and Sc, which cannot be measured by quadrupole inductively coupled plasma mass spectrometry, are vital for more accurate classification.
The first full study of heavy metal(loid)s in western-European hedgehogs (Erinaceus europaeus) from Portugal
Authors: Jota Baptista Catarina , Seixas Fernanda , Gonzalo-Orden José M. , Patinha Carla , Pato Pedro , Ferreira da Silva Eduardo , Casero María , Brazio Erica , Brandão Ricardo , Costa Daniela , Mateus Teresa L. , Coelho Ana C. , Oliveira Paula. A. 
Published: January 2024

AbstractThe western-European hedgehog (Erinaceus europaeus) is an insectivore with a wide distribution in Portugal and a potential tool for biomonitoring relevant One Health hazards, including heavy metal(loid)s’ pollution. The aim of this study was to positively contribute to the current knowledge about the metal(loid) pollution in Portugal. Forty-six hedgehogs (from rescue centres; with known provenance) were necropsied. Sex, age category and weight were determined. Spines, liver and kidney were collected, and metalloid concentrations were determined by inductively coupled plasma mass spectrophotometry (ICP-MS). In general, results did not present alarming metal(loid) concentrations, with the exception of cadmium (Cd) (in the kidneys) and copper (Cu). Hedgehogs from Viana do Castelo and Viseu showed elevated concentrations of arsenic (As) and Castelo Branco presented concerning values of cadmium (Cd). Adult and heavier hedgehogs tended to present higher levels of metal(loid)s. Sex does not seem to significantly affect the metal(loid)s’ concentrations. Further analysis would be needed to prioritize areas with detail and allow the application of the necessary mitigation strategies.
Arbeitsweltbezogene Positionierungen Jugendlicher im Kontext sozialer Benachteiligung
Authors: Hirschfeld Heidi , Lenz Bianca , Walther Andreas 
Published: January 2024

ZusammenfassungÜbergänge benachteiligter Jugendlicher und junger Erwachsener, denen der Übergang in eine anerkannte und subjektiv zufriedenstellende Ausbildung und/oder Erwerbsarbeit nicht bruchlos gelingt, werden durch institutionelle Übergangshilfen unter Beteiligung von und Rekurs auf sozialpädagogische Praxis reguliert und prozessiert. Im Kontext des aktivierenden Wohlfahrtsstaats erfolgt dies zunehmend durch individualisierte Fallführung und „Hilfen aus einer Hand“. Mit dem Konzept der arbeitsweltbezogenen Positionierung fragt der Beitrag, wie sich Arbeitsorientierungen und Berufsperspektiven Jugendlicher und junger Erwachsener in einem Wechselverhältnis des Positioniert-Werdens und Sich-Positionierens formieren. Im Beitrag wird zunächst vor dem Hintergrund des deutschsprachigen Forschungsstands zu Arbeitsorientierungen und Berufsperspektiven junger Menschen und des Konzepts Doing Transitions die Heuristik arbeitsweltbezogene Positionierung entwickelt. Anschließend werden im Sinne eines minimal-kontrastiven Vergleichs Entwicklungen institutioneller Fallführung der Übergänge benachteiligter Jugendlicher in Deutschland und der Schweiz beschrieben und an jeweils zwei Fällen ihr Beitrag zu Prozessen arbeitsweltbezogener Positionierung rekonstruiert.
Low expression of PRRG2 in kidney renal clear cell carcinoma: an immune infiltration-associated prognostic biomarker
Authors: Tang Gonglin , Ding Guixin , Wu Gang , Wang Xiaofeng , Wang Tianqi , Zou Qingsong , Sun Kai , Wu Jitao 
Published: January 2024

Abstract
Objective
This study aims to explore the prognostic significance of Proline-rich γ-carboxyglutamic acid protein 2 (PRRG2) in Kidney Renal Clear Cell Carcinoma (KIRC), a prevalent and deadly cancer, and its association with immune cell infiltration, a key strategy in developing effective biomarkers.

Methods
The study meticulously elucidated the prognostic significance and potential role of PRRG2 in KIRC, correlating its expression with patient sex, age, metastasis, and pathological stage. Utilizing Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA), the involvement of PRRG2 in immune response was investigated. The association between PRRG2 expression and immune cell infiltration was also scrutinized. Ultimately, cellular and tissue identity were confirmed via immunohistochemical staining and quantitative real-time PCR.

Results
The study elucidates a notable decrease in PRRG2 expression in KIRC patients, correlating with demographic factors, metastasis, and pathological staging, and portending an unfavorable prognosis. Bioinformatic analyses underscore PRRG2’s role in immune response, with its expression significantly tied to immune cell infiltration and marker expression.

Conclusion
PRRG2 may potentially impact prognosis in KIRC patients by regulating immune infiltration, thus rendering PRRG2 a promising candidate prognostic biomarker for KIRC-associated immune infiltration.
Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis
Authors: Sato Kenichiro , Niimi Yoshiki , Ihara Ryoko , Iwata Atsushi , Ikeuchi Takeshi , Iwatsubo Takeshi 
Published: January 2024

AbstractThe APOE-ε4 allele(s) is a strong risk factor for Alzheimer’s disease (AD). A significant point of access for this allele testing is through services provided by medical facilities in Japan, which advertise out-of-insurance APOE testing on their websites. There is a concern that website advertisements for APOE testing may influence the ability for individuals to adequately self-determine whether to undergo APOE testing. We conducted a cross-sectional survey on medical facility websites in Japan advertising APOE genetic testing. We predefined desirable features for advertisement descriptions based on legal regulations and guidelines published by relevant professional societies and evaluated each website according to these features. We identified 220 medical facilities that had posted advertisements on their websites for the provision of APOE genetic testing, of which 85% were small clinics. Contact information, details, and costs of testing were described in most of the websites. Meanwhile, features such as “explaining APOE as a risk gene,” “notes on interpreting APOE results,” or “explaining examination methods” (e.g., blood sampling) were described to a variable degree depending on individual facilities. “Notes on genetic testing” or “referring to genetic counseling” were hardly referred to, and specialists with appropriate expertise were considered to participate in clinical practice in approximately one-third of these facilities providing APOE testing services. These website evaluation results showed moderate to substantial reliability between independent raters. These results suggest that self-determination of pursuing out-of-insurance APOE testing at some medical facilities in Japan may possibly be influenced in an inappropriate manner, at least in its entry route of taking the test.
Hardly Venus’s servant—morphological adaptations of Veneriserva to an endoparasitic lifestyle and its phylogenetic position within Dorvilleidae (Annelida)
Authors: Tilic Ekin , Rouse Greg W. 
Published: January 2024

AbstractEndoparasitic annelids living inside another annelid host are known, particularly with regard to Oenonidae, but in general are poorly studied. The dorvilleid Veneriserva pygoclava is known from southern California, and its genus name (Latin = Venus’s servant) alludes to the close association with the host aphroditid scaleworm Aphrodita longipalpa. Little is known on fundamental questions on the biology of Veneriserva pygoclava. What is its mode of reproduction? How do they feed? How do they penetrate the host? We have studied multiple parasitized hosts and V. pygoclava specimens, using an integrative approach, combining µCT, histology, and electron microscopy. 3D reconstructions from µCT data of a parasitized Aphrodita show the exact position of the parasites in their natural condition within the host’s coelomic cavity. Ultrastructural investigations of the parasites revealed interesting adaptations to their lifestyle such as the complete reduction of their gut, despite the presence of a functional jaw apparatus and a modified epidermis enabling nutrient uptake from the host’s coelomic fluid. In addition to these, we also investigated spermatogenesis and oogenesis in V. pygoclava. Sperm morphology indicates an external fertilization of eggs within the coelomic cavity of the host. Mature male and female parasites living inside the same mature host and the presence of juvenile V. pygoclava within juveniles of Aphrodita suggest an obligate form of parasitism with a very early penetration of the hosts. In addition to our detailed morphological investigation, we conducted a phylogenetic analysis showing the position of Veneriserva within Dorvilleidae and its position was recovered nested among taxa of the Iphitime. Our phylogenetic analyses also show that the taxation Ophryotrocha puerilis siberti should be given full species rank and referred to as Ophryotrocha siberti. Finally, we publish here the full mitochondrial genome of V. pygoclava and discuss its novel gene order with reference to other annelids.
Modeling and Simulation of Elevation Dynamics of Main Battle Tank Weapon System with Linear Graph Method
Authors: Cakir Muhammed Fatih , Sezer Semih , Bayraktar Meral 
Published: January 2024

AbstractThe use of main battle tanks in armies goes back many years. The most crucial component is undoubtedly the weapon system. In this study, it is aimed to model the elevation dynamics of the weapon system that provides the movement of the weapon system in the vertical axis. The elevation dynamics consists of three parts: an electric motor, a driver, and a barrel. Both parts are expected to have similar vibration characteristics. The linear graph method was preferred as the modeling method. First of all, the system components and types were determined, and the linear graph, normal tree, and tree links of the system were drawn. Then the state variables, primary and secondary variables, as well as the number of branches, nodes, and sources, were determined, respectively. Elemental, continuity, and compatibility equations were written using the obtained graphs. By organizing these equations, state equations were obtained in standard form and matrix form. With the simulation studies carried out in MATLAB/Simulink, the displacement, velocity, and acceleration responses of the breech and muzzle sections were obtained. It is seen that obtained angular displacement, velocity, and acceleration results for both breech and muzzle sections are almost the same. As a result, the breech and muzzle sections have similar vibration motions and have proven to be able to work in harmony. This result shows that the barrel can be designed from two parts without additional stress and tension, which makes it difficult to focus on the target. By forming the barrel in two parts, the risk of damage can be minimized by better distributing the stress and tension occurring in the barrel during firing.
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
Authors: Qin Shihui , Li Yanlang , Shao Huiyan , Yu Yang , Yang Yina , Zeng Yi , Huang Jia , Hu Jiang-miao , Yang Liu 
Published: January 2024

AbstractAs the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction between them has been a topic of intense research. This study provides an in-depth investigation of the interaction mechanism between corn silk glycans and luteoloside (LUT) and the synergistic role that result from this interaction. The interaction mechanism was evaluated by isothermal titration calorimetry (ITC) and circular dichroism (CD), and the synergistic role was evaluated by the expression of glucose transporters (GLUT-1), insulin secretion and surface plasmon resonance (SPR). CD and ITC results indicated that the interaction between CSGs and LUT mainly driven by the Cotton effects, enthalpy and entropy-driven. This interaction precipitated the formation of complexes (CSGs/LUT complexes) between corn silk glycans (CSGs) with four different molecular weights and luteoloside (LUT). Furthermore, the CSGs and LUT play a synergistic role in glucose regulation through GLUT-1 expression and insulin secretion experiments, compared to single luteoloside group.
Graphical Abstract
Existence of the solution of nonlinear fractional differential equations via new best proximity point results
Authors: Aslantaş Mustafa 
Published: January 2024

AbstractIn this paper, we obtain some best proximity point results by introducing the concepts of proximal p-contractions of the first type and proximal p -contractions of the second type on partial metric spaces. Thus, some famous results in the literature such as the main result of Altun et al. (Acta Math Hung 162:393–402, 2020) and Basha (J Approx Theory 163(11):1772–1781, 2011) have been extended. Also, we provide some examples where our results are applicable and the results in Haghi et al. (Topol Appl 160:450–454, 2013) are not. Hence, our results are a real generalization of some results in metric spaces and partial metric spaces. Finally, we obtain sufficient conditions for the existence of the solution of nonlinear fractional differential equations via our results.