bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggressive systemic mastocytosis with multiple organ involvement: a case report
Authors: Iranijam Effat , Salimi Maryam , Negaresh Mohammad , Javanshir Nima 
Published: November 2023

Abstract
Systemic mastocytosis is a rare malignancy whose main diagnostic finding is the abnormal proliferation of clonal mast cells. In this report, a 63-year-old woman is presented who was referred to the emergency department with lower back pain. Due to the hypereosinophilia in blood tests, a bone marrow biopsy was performed, and except for the presence of a large number of mastocytes, no other pathologic findings were seen. Furthermore, the immunohistochemistry test showed positive CD117 and CD25 markers, and the patient’s platelet-derived growth factor receptor alpha test was positive. Hence, the patient was diagnosed with aggressive systemic mastocytosis. Treatment was initiated with the Cladribine regimen, but unfortunately, in the third course, the patient experienced bradycardia and loss of consciousness and expired. Systemic mastocytosis can manifest itself with non-cutaneous symptoms. Non-cutaneous symptoms do not rule out systemic mastocytosis as a differential diagnosis in patients with hypereosinophilia.
When do default nudges work?
Authors: Bonander Carl , Ekman Mats , Jakobsson Niklas 
Published: November 2023

Abstract
Nudging is a burgeoning topic in science and in policy, but evidence on the effectiveness of nudges among differentially incentivized groups is lacking. This paper exploits regional variations in the rollout of the Covid-19 vaccine in Sweden to examine the effect of a nudge on groups whose intrinsic incentives are different: 16- to 17-year-olds, for whom Covid-19 is not dangerous, and 50- to 59-year-olds, who face a substantial risk of death or severe disease. We find a significantly stronger response in the younger group compared with the older (11.7 vs 3.6 percentage point increase in our study period), consistent with the theory that nudges are more effective for choices that are not meaningful to the individual.
Estrogen-dependent expression and function of secretogranin 2a in female-specific peptidergic neurons
Authors: Fleming Thomas , Tachizawa Masaya , Nishiike Yuji , Koiwa Ai , Homan Yuki , Okubo Kataaki 
Published: November 2023

Abstract
Secretogranin 2 (Scg2) is a member of the secretogranin/chromogranin family of proteins that is involved in neuropeptide and hormone packaging to secretory granules and serves as a precursor for several secreted pleiotropic peptides. A recent study in zebrafish showed that the teleost Scg2 orthologs, scg2a and scg2b, play an important role in mating behavior, but its modes of action and regulatory mechanisms remain unclear. In this study, we identify scg2a in another teleost species, medaka, by transcriptomic analysis as a gene that is expressed in an ovarian secretion-dependent manner in a group of neurons relevant to female sexual receptivity, termed FeSP neurons. Investigation of scg2a expression in the FeSP neurons of estrogen receptor (Esr)-deficient medaka revealed that it is dependent on estrogen signaling through Esr2b, the major determinant of female-typical mating behavior. Generation and characterization of scg2a-deficient medaka showed no overt changes in secretory granule packaging in FeSP neurons. This, along with the observation that Scg2a and neuropeptide B, a major neuropeptide produced by FeSP neurons, colocalize in a majority of secretory granules, suggests that Scg2a mainly serves as a precursor for secreted peptides that act in conjunction with neuropeptide B. Further, scg2a showed sexually biased expression in several brain nuclei implicated in mating behavior. However, we found no significant impact of scg2a deficiency on the performance of mating behavior in either sex. Collectively, our results indicate that, although perhaps not essential for mating behavior, scg2a acts in an estrogen/Esr2b signaling-dependent manner in neurons that are relevant to female sexual receptivity.
Analysing the role of police officer strength in the crime drop in England
Authors: Tura Ferhat , Hunter James , Thompson Rebecca , Tseloni Andromachi 
Published: November 2023

Abstract
According to evidence from the Crime Survey for England and Wales (CSEW), there have been significant falls in crime levels in England and Wales since the 1990s. Many hypotheses have been proposed to explain these falls. However, there is scarce research on the role of the number of police officers in bringing about the crime drop in the UK. We fitted multilevel models to analyse the role of the number of police officers in the crime drop in England between 1991 and 2001 using a variety of data sources, including police recorded crime data, UK Census data, and police workforce data. We found that the role of police officer strength in the crime drop in England was limited to vehicle thefts, thefts from vehicle, and thefts from person. Given the relatively mixed picture, we recommend that police forces should focus on what newly recruited police officers do and where they are deployed, as opposed to becoming too focussed on the number of officers. More implications of the findings in relation to the recent Police Uplift Programme are discussed.
Learned interferometric imaging for the SPIDER instrument
Authors: Mars Matthijs , Betcke Marta M , McEwen Jason D 
Published: November 2023

Abstract
The Segmented Planar Imaging Detector for Electro-Optical Reconnaissance (SPIDER) is an optical interferometric imaging device that aims to offer an alternative to the large space telescope designs of today with reduced size, weight, and power consumption. This is achieved through interferometric imaging. State-of-the-art methods for reconstructing images from interferometric measurements adopt proximal optimization techniques, which are computationally expensive and require handcrafted priors. In this work, we present two data-driven approaches for reconstructing images from measurements made by the SPIDER instrument. These approaches use deep learning to learn prior information from training data, increasing the reconstruction quality, and significantly reducing the computation time required to recover images by orders of magnitude. Reconstruction time is reduced to ∼10 ms, opening up the possibility of real-time imaging with SPIDER for the first time. Furthermore, we show that these methods can also be applied in domains where training data are scarce, such as astronomical imaging, by leveraging transfer learning from domains where plenty of training data are available.
Status and developmental trends in recombinant collagen preparation technology
Authors: Guo Xiaolei , Ma Yuan , Wang Hang , Yin Hongping , Shi Xinli , Chen Yiqin , Gao Guobiao , Sun Lei , Wang Jiadao , Wang Yunbing , Fan Daidi 
Published: November 2023

Abstract
Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineering technologies. These technological advancements have profound implications across diverse areas such as regenerative medicine, organ replacement, tissue engineering, cosmetics and more. Thus, recombinant collagen and its preparation methodologies rooted in genetically engineered cells mark pivotal milestones in medical product research. This article provides a comprehensive overview of the current genetic engineering technologies and methods used in the production of recombinant collagen, as well as the conventional production process and quality control detection methods for this material. Furthermore, the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies, envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.
Taking aim at innovation-crushing mergers: a killer instinct unleashed?
Authors: Eben Magali , Reader David 
Published: November 2023

Abstract
The European Union (EU) has assigned competition policy an important role as part of an extensive new agenda to stimulate innovation, including by fostering the growth of small and medium-sized enterprises (SMEs). The ability of EU merger control to be receptive and responsive to innovation harms has therefore come under scrutiny, with some observers doubting its capacity to address innovation-crushing ‘killer acquisitions’ of innovative SMEs. This article reflects on several recent developments that have shaped the EU’s response to these doubts. Substantively, the more central role afforded to innovation considerations in the European Commission’s recent enforcement practice may well demonstrate its willingness to engage with innovation theories of harm in mainstream merger control going forward, although questions remain about the standards and methodology it can adopt under the EU Merger Regulation (EUMR). Jurisdictionally, the recalibrated approach to the Article 22 EUMR referral mechanism—assisted, in certain circumstances, by the new pre-merger information obligation for digital gatekeepers under Article 14 DMA—is capable of bringing an almost boundless range of cases before the Commission. The Towercast judgment casts the net further still, by confirming the potential for below-threshold mergers to face ex post reviews at the national level under the Article 102 TFEU abuse of dominance prohibition. The effect of these developments is that the Commission and national competition authorities may now be better equipped to unleash a killer instinct when faced with innovation concerns arising from killer acquisitions. However, an unwelcome pendulum swing towards over-enforcement risks untold harm to legal certainty, merger activity, and innovation itself.
Genomic Features of the Host-Specific Fungal Biocontrol Agent Ramularia crupinae Approved for the Management of the Federally Noxious Weed Crupina vulgaris
Authors: Tancos Matthew A. , Fulcher Michael R. 
Published: November 2023

Ramularia crupinae is a novel host-specific fungal pathogen of the invasive rangeland weed common crupina ( Crupina vulgaris). The foliar and stem blighting pathogen was originally identified in France and has been approved by the United States Department of Agriculture–Animal and Plant Health Inspection Service as the first biological control agent for the management of common crupina in the western United States. In this study, a chromosome-level genome assembly of R. crupinae 00-010 was performed using PacBio sequencing technology. The assembly had a total size of 37.9 Mb distributed across 14 (telomere to telomere) chromosomes, with a GC content of 47.6%. The genome encoded 10,159 protein-coding genes with 890 predicted secreted proteins that comprised both unique and conserved canonical pathogen effectors. Genome comparisons with closely related pathogen species in the family Mycosphaerellaceae demonstrated family-wide orthologous effector groups and Ramularia-specific orthogroups. This new reference sequence is a valuable genomic tool that will assist in characterizing Ramularia–Crupina interactions and increase our understanding of Ramularia pathogenicity on both crops and weeds. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2024.
The Impact of Inadequate Energy Intake on Readmission Burden of Patients With Heart Failure
Authors: Li Anan , Zhu Chenya , Cheng Ming , Su Yue , Ma Tianyu , Chi Meixuan , Wang Naijuan , Nie Yangfan , Hou Yunying 
Published: November 2023

Background
Adequate energy intake is essential for good clinical outcomes. The association between energy intake and readmission burden of patients with heart failure (HF) still needs to be clarified.

Objective
In this study, our aim was to determine the association between energy intake and readmission in patients with HF.

Methods
A total of 311 inpatients with HF were recruited. Demographic and clinical information were collected during hospitalization; the daily diets of the participants were collected in the second week after discharge using the 3-day diet record, and the energy intake was calculated using a standardized nutrition calculator. The inadequate energy intake was defined as <70% × 25 kcal/kg of ideal body weight. The participants were followed up for 12 weeks after discharge. The number, reasons, and length of stay of unplanned readmissions were collected. Regression analyses were used to evaluate the associations between inadequate energy intake, and readmission rate and readmission days.

Results
The median of the energy intake of participants was 1032 (interquartile range, 809–1266) kcal/d. The prevalence of inadequate energy intake was 40%. Patients with inadequate energy intake had a higher risk of unplanned readmission (odds ratio, 5.616; 95% confidence interval, 3.015–10.462; P < .001) and more readmission days (incidence rate ratio, 5.226; 95% confidence interval, 3.829–7.134, P < .001) after adjusting for potential confounders.

Conclusions
Patients with HF had a high incidence of inadequate dietary energy intake, and it increases the burden of readmission.
Identification of ferroptosis-related genes in acute kidney injury by bioinformatic analysis
Authors: Ye Jianfeng , Cen Yun , Li Man , Gu Wanjie , Lu Xuehao , Zhao Fengzhi , Shi Bowen , Xu Jun , Yin Haiyan 
Published: November 2023

ABSTRACT

Background:
Acute kidney injury (AKI) is a rapid decline in renal function characterized by a decrease in glomerular filtration rate in a short period. Ferroptosis affects the development of various kidney diseases. Therefore, searching for genes related to ferroptosis is crucial for understanding the occurrence and development of AKI.

Methods:
We obtained data from 18 samples (8 with acute kidney injury and 10 non-pathological tissue) in GSE53769 and 48 samples (39 with acute kidney injury and 9 non-pathological tissue) in GSE139061. We obtained differentially expressed genes (DEGs) of AKI/Control samples from both two datasets and intersected them with known ferroptosis-related genes (FRGs) to obtain ferroptosis-related DEGs (FRDEGs). GO annotation, KEGG pathway analysis, and GSEA analysis were conducted on the FRDEGs to understand their enriched biological functions and pathways. Next, we constructed the protein-protein interaction (PPI) network.

Results:
A total of 312 genes were obtained, which were abnormally expressed in both two datasets. After intersecting with known FRGs, 14 FRDEGs were obtained, namely ACSF2, ADIPOR1, ARF6, ATF3, ATF6, DPEP1, FH, GLRX5, MIOX, NAP1L1, NDRG1, PPARA, SPHK1, YY1AP1. The results of the immune infiltration analysis showed that multiple gene expressions among 14 genes are correlated with immune cell infiltration.

Conclusion:
Fourteen ferroptosis genes (ACSF2, ADIPOR1, ARF6, ATF3, ATF6, DPEP1, FH, GLRX5, MIOX, NAP1L1, NDRG1, PPARA, SPHK1, YY1AP1) are involved in the occurrence and development of AKI, among which NDRG1 might be the core functional gene, and PPARA is expected to become the most effective therapeutic target gene.
Symptom Outcomes of Celiac Disease in Those on a Gluten-free Diet
Authors: Hujoel Isabel A. , Hujoel Margaux L.A. , Choung Rok Seon , Murray Joseph A. 
Published: November 2023

Goals:
We aimed to evaluate symptom outcomes in those on a gluten-free diet during the 5 years after diagnosis.

Background:
Celiac disease is common; however, little is known about long-term symptom outcomes.

Study:
We performed a retrospective chart review on individuals with celiac disease followed at a tertiary referral center between 2012 and 2018. To minimize bias, strict inclusion/exclusion criteria were utilized. Only those with definitive biopsy-proven celiac disease, on a gluten-free diet, and with systematic follow-up were included. The standardized care at this center reduced the risk that decisions on testing and follow-up visits were determined by symptom status. Summary statistics were computed and generalized linear models with a logit link were used to associate the proportion of symptomatic visits with various covariates using R statistical programming.

Results:
Of the 1023 records reviewed, 212 met inclusion/exclusion criteria; 146 (69%) were female and the mean age at diagnosis was 43 (range: 11 to 84 y old). During follow-up, over 50% remained symptomatic, with many having the same symptoms that prompted the diagnosis. The only predictors for remaining symptomatic were female sex and younger age at diagnosis. Abnormal serology during follow-up and small bowel normalization were not predictive.

Conclusions:
In individuals with definitive celiac disease with systematic long-term follow-up in a Celiac Clinic, roughly half remained symptomatic despite a gluten-free diet. Many suffer from the same symptoms that prompted the diagnosis of celiac disease. Small bowel healing and abnormal serology in follow-up were not predictive of remaining symptomatic. These findings stress the importance of long-term care in celiac disease.
Safety of Percutaneous Endoscopic Jejunostomy Placement Compared With Surgical and Radiologic Jejunostomy Placement
Authors: Ramai Daryl , Heaton Joseph , Fang John 
Published: November 2023

Background and Aims:
We compared the safety and outcomes of percutaneous jejunostomy tubes placed endoscopically (PEJ), fluoroscopically by interventional radiology (IR-jejunostomy), and open jejunostomy placed surgically (surgical jejunostomy).

Methods:
Using the Nationwide Readmissions Database, we identified hospitalized patients who underwent a jejunostomy from 2016 to 2019. Selected patients were divided into 3 cohorts: PEJ, IR-jejunostomy, and surgical jejunostomy. Adjusted odds ratios (OR) for adverse events were calculated using multivariable logistic regression analysis.

Results:
A total of 6022 (65.2±9.8 y) surgical jejunostomy patients, 3715 (63.6±11.0 y) endoscopic jejunostomy patients, and 14,912 (64.8±11.6 y) IR-jejunostomy patients were identified. Compared with surgery, PEJ patients were 32% less likely to experience postprocedure complications (OR: 0.68; 95% CI: 0.58-0.79, P<0.001) while IR-jejunostomy patients were 17% less likely to experience complications (OR: 0.83; 95% CI: 0.73-0.94, P<0.001); test of proportion showed that endoscopy had significantly fewer total adverse events compared with IR (P<0.001). For individual complications, compared with surgery, the odds of intestinal perforation using PEJ and IR, respectively, were 0.26 (95% CI: 0.14-0.49, P<0.001) and 0.31 (95% CI: 0.21-0.47, P<0.001), for postprocedure infection 0.32 (95% CI: 0.20-0.50; P<0.001) and 0.61 (95% CI: 0.45-0.83; P=0.001); and for hemorrhage requiring blood transfusion 0.71 (95% CI: 0.56-0.91; P=0.005) and 0.75 (95% CI: 0.61-0.91; P=0.003).

Conclusions:
Endoscopic placement of percutaneous jejunostomy tubes (PEJ) in inpatients is associated with significantly lower risks of adverse events and mortality compared with IR and surgical jejunostomy.
Use of his prostheses by a double upper limb amputee 6 years after amputation: From aesthetic to functional considerations, a case report
Authors: Noël Camille , Viton Jean-Michel , Bensoussan Laurent , Cotinat Maëva 
Published: November 2023

Background:
Few studies have been published on the prosthetic management of bilateral upper limb amputees. Of particular interest is to study how a patient’s use of his upper limb protheses had evolved over a 6-year period in the aim to decrease their rejection rate.

Case description and methods:
Mr. D had undergone a bilateral upper limb amputation and had been fitted with 7 different prostheses in the past 6 years. Multiple validate instruments and analyses were then used to monitor the patient’s fitting and choices.

Findings and outcomes:
Initially, the left prosthesis was regarded as the dominant hand and the right one as the assistive power grip hand. However, the observational results showed that wearing only a left Greifer enabled the prosthetic user to perform the same tasks as with 2 prostheses. He has gained greater satisfaction and quality of life without losing his independence.

Conclusion:
The patient seemed to make a functional choice over his worrying about his physical appearance in favor of the efficiency of his prosthesis, which was essential for his everyday life, when he decided to wear only nonanthropomorphic prosthesis.
Lived experience of children and adolescents with lower-limb loss who used a prosthesis: A qualitative study
Authors: Chami Sara , Babaee Taher , Jalali Maryam , Saeedi Hassan , Kamali Mohammad 
Published: November 2023

Purpose:
Children's and adolescents' level of activity, the type of activity, and other features are special to them and can result in unique experiences with lower-limb prosthesis. The specific objective of this study was to explore the lived experience of children and adolescents with lower-limb loss (LLL) who used a prosthesis.

Methods:
We used a descriptive qualitative study design and in-depth, semistructured, face-to-face interviews. Accordingly, 35 participants, including children and adolescents with LLL who used a prosthesis, their parents, and prosthetists, were interviewed. The collected data were analyzed thematically.

Results:
One hundred sixty-eight codes about the experiences of children, parent(s), and prosthetists were extracted from the transcripts and categorized into 32 subthemes. Finally, 7 broad themes including suitability, provoke reactions, intrinsic nature, infrastructures, the school, availability, and parenting role were extracted.

Conclusion:
The experiences of children and adolescents with lower-limb prosthesis are specific as each may face unique challenges and deal with different difficulties. In this study that has been conducted in a developing country, the main challenges faced by children using lower-limb prosthesis and their parents are the prosthetic components, social reactions, long distance, and costs of services. Moreover, designing a more natural prosthesis and gait training for children with LLL were the most important issues faced by prosthetists. However, close relationships with friends and family members, and children’s amazing ability to adapt can aid in facilitating prosthetic management.