bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of midostaurin in plasma and serum by stable isotope dilution liquid chromatography‐tandem mass spectrometry: Application to a cohort of patients with acute myeloid leukemia
Authors: Wiesen Martin H. J. , Stemler Jannik , Fietz Cornelia , Joisten Carolin , Cornely Oliver A. , Verougstraete Nick , Streichert Thomas , Müller Carsten 
Published: February 2024

AbstractObjectivesMidostaurin is an oral multitargeted tyrosine kinase inhibitor for the treatment of acute myeloid leukemia (AML). Therapeutic drug monitoring of midostaurin may support its safe use when suspecting toxicity or combined with strong CYP3A4 inhibitors.MethodsA stable isotope dilution liquid chromatography–tandem mass spectrometry method was developed and validated for the determination and quantification of midostaurin in human plasma and serum. Midostaurin serum concentrations were analyzed in 12 patients with FMS‐like tyrosine kinase 3 (FLT3)‐mutated AML during induction chemotherapy with cytarabine, daunorubicin, and midostaurin. Posaconazole was used as prophylaxis of invasive fungal infections.ResultsLinear quantification of midostaurin was demonstrated across a concentration range of 0.01–8.00 mg/L. Inter‐ and intraday imprecisions of the proposed method were well within ±10%. Venous blood samples were taken in nine and three patients in the first and second cycle of induction chemotherapy. Median (range) midostaurin serum concentration was 7.9 mg/L (1.5–26.1 mg/L) as determined in 37 independent serum specimens.ConclusionIn a real‐life cohort of AML patients, interindividual variability in midostaurin serum concentrations was high, highlighting issues concerning optimal drug dosing in AML patients. A personalized dosage approach may maximize the safety of midostaurin. Prospective studies and standardization of analytical methods to support such an approach are needed.
Optimal timing of return migration in Atlantic salmon
Authors: Foldvik Anders , Ulvan Eva Marita , Næsje Tor 
Published: February 2024

AbstractIn many populations of Atlantic salmon, individuals return to rivers months or even a year prior to spawning. This premature arrival in fresh water by far exceeds the time needed for upstream migrations to spawning areas. Leaving the ocean early means forgoing substantial growth and incurring high metabolic costs of fasting in freshwater. Differences in timing of return migration has been shown to have a genetic basis, and different sea age classes return to rivers at different times. Previously suggested explanations regarding the cause for this behaviour have included both environmental factors and life history trade‐offs, but these hypotheses have not been tested. Here, we combine data on marine growth and mortality of Atlantic salmon with the calculations of energetic expenditures of fasting in freshwater to explore how timing of river entry affects the probability of survival and energy recourses available for spawning. Our results show that to maximize the product of survival until spawning and energy available at spawning, multi sea winter fish in general must enter rivers earlier than one sea winter fish. And that for a large range of sea survival rates, the optimum river entry date for multi sea winter fish is as early as possible. This strongly suggests that the phenomena of premature arrival in Atlantic salmon is adaptive behaviour.
Taking a chance on China: African student‐entrepreneurs in greater Zhejiang Province
Authors: Rothschild Viola 
Published: February 2024

AbstractDriven by macro‐level investment and strategic competition, engagement between China and African countries has expanded significantly in recent years, giving rise to increased migration flows between the two regions. Wary of Beijing's growing influence on the continent, Western scholarship and media often portray China as extractive and neo‐colonialist, whereas Africa and Africans are depicted as passive and lacking agency. This study examines an important yet understudied group operating at the crux of contemporary Sino–African relations that challenges these assumptions: young, African student‐entrepreneurs studying and working in China. Drawing on data from 10 months of ethnographic fieldwork and interviews with African student‐traders, as well as Chinese university administrators, students, and officials, this study finds that African student‐traders have developed a set of strategies that allow them to navigate, exploit and reconfigure Chinese structures as they pursue their entrepreneurial aspirations, suggesting that the Sino–African relationship is far from one‐sided.
Craft breweries and residential property values
Authors: Zhou Yang , Reid Neil , Carroll Michael C. 
Published: February 2024

AbstractThis paper studies the effect of craft breweries on residential property values. Using a hedonic Difference‐in‐Differences (DID) approach and about 250 thousand housing transactions in Denver, Colorado from 1990 to 2016, we investigate the impact of proximity to a craft brewery on residential property values. We consider three types of residence (single‐family home, row house, and condominiums), three types of brewery (all craft breweries, microbreweries, and brewpubs/taprooms), and two measurements of distance (Euclidian and walk‐time). Our most robust results are found for single‐family homes, whose values enjoy a premium of up to 20.4% for being in proximity to a brewpub/taproom several years after, with the average annual maximum premium around 3%. As expected, premiums decline as distance from breweries increase. Beyond a distance of 0.5 km or a 10‐min walk‐time, the premium for a regional/microbrewery is greater than that for a brewpub/taproom. For single family homes within 4 km or 40‐min walk‐time, the annualized premium ranges between 0.41% and 3.01%. These findings support the narrative that craft breweries are a neighborhood asset.
Risk factors related to surgical wound infection after caesarean section: A systematic review and meta‐analysis
Authors: Zhu Dawei , Wu Yujie , Fan Lin , Liu Xinghui 
Published: February 2024

AbstractSurgical site infection (SSI) is one of the common postoperative complications after caesarean section for pregnant women. Previous studies have investigated the risk factors for SSI in pregnant women undergoing caesarean delivery. Whereas big differences in research results exist, and the correlation coefficients of different research results are quite different. A meta‐analysis was conducted to examine the risk factors related to SSI in pregnant women undergoing caesarean delivery. We searched English databases to collect case–control studies or cohort studies published between 1 January 2015 and 15 November 2023, including PubMed, Web of Science and ScienceDirect. The risk of bias of the included studies was assessed via Newcastle‐Ottawa Scale. The analysis was performed using RevMan 5.4.1 tool. A total of 24 articles (n = 581, 895) were selected in this meta‐analysis. The following risk factors were presented to be significantly correlated with SSI in pregnant women following caesarean delivery: smoking (odds ratio [OR] = 1.64, 95% confidence interval [CI] [1.31, 2.04]), previous caesarean section (OR = 1.46, 95% CI [1.18, 1.82]), multiple vaginal examinations (OR = 2.92, 95% CI [1.91, 4.46]), membrane rupture (OR = 1.68, 95% CI [1.19, 2.38]), hypertensive disorders (OR = 1.85, 95% CI [1.33, 2.57]), diabetes mellitus (OR = 1.36, 95% CI [1.18, 1.57]), high body mass index (OR = 1.57, 95% CI [1.35, 1.84]). Occurrence of SSI is influenced by a variety of factors. Thus, we should pay close attention to high‐risk subjects and take crucial targeted interventions to lower the SSI risk after caesarean section. Owing to the limited quality and quantity of the included studies, more rigorous studies with adequate sample sizes are needed to verify the conclusion.
Telemedicine models of care: A retrospective review of telehealth in a Melbourne outpatient chronic wound service in 2021
Authors: Burger Sarah Jacqueline , Sage Sarah , Bondini Carla Maree , Ly Ngoc Bao Huynh , Iseli Rebecca Kate 
Published: February 2024

AbstractTo review the application of telehealth guidelines developed by Bondini et al for clinicians to determine patient suitability for telehealth in an outpatient Chronic Wound Service, including the proportion of patients suitable for telehealth, type and mode of telehealth encounters. Retrospective, random convenience sample of patients attending the Chronic Wound Service in 2021. Fifty‐six patients were included, most with leg/foot wounds (93%), median age 74 [54–84], 64% male. Four patients at admission and 19 patients at review met criteria for telehealth. Six percent of encounters were telehealth; phone‐only (82%), unscheduled nursing reviews (77%) in patients with healing wounds. Thirty patients (54%) received at least one telehealth encounter. Telehealth occurred 35.6 days later in the admission than face‐to‐face encounters (p < 0.05, 95% CI 14.9–56.3). There was a significant relationship between patients receiving telehealth and meeting telehealth suitability criteria on reviews (X2 (1) = 19.6*, p < 0.001). Eighteen percent of patients required wound‐related hospitalisation during their outpatient admission. Telehealth guidelines identified patients suitable for telehealth, although the proportion of patients was small. Telehealth was mostly utilised for nurse‐led telephone calls in patients with improving wounds. Future research into use of telephone review for clinical standards of wound care is warranted.
Studying the effects of stress, mental health and psychological well‐being on wound healing rates after oesophageal varices ligation in liver cirrhosis patients
Authors: Yu Hui Xi , Fu Ling Xue , Wang Yi Ying , Zheng Sheng Li 
Published: February 2024

AbstractIt is of utmost importance to comprehend the impact that psychological factors have on physical rehabilitation, specifically in regards to wound healing following ligation of oesophageal varices in patients with liver cirrhosis. The present study investigated the correlation between wound recovery rates and psychological well‐being, stress and mental health. From January 2022 to September 2023, 148 patients from were evaluated as part of this cross‐sectional observational study. The psychological well‐being of participants was evaluated utilizing the Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS) and Psychological General Well‐Being Index (PGWBI). The rates of wound recovery were assessed following ligation. The mean duration for wound recovery was 28.37 ± 9.65 days. The mean wounds healing time of patients who obtained higher PSS scores (18.55) was marginally longer. On the contrary, there was a moderate reduction in healing time associated with higher HADS scores (mean 14.10). On average (68.88), PGWBI scores indicated a negligible effect on wound healing. The variance in healing durations between Child‐Pugh classifications A, B and C (mean values of 28.65, 26.90 and 29.57 days respectively) suggested that the severity of liver disease has an impact. As a result of ligation of oesophageal varices, the study demonstrated that psychological factors and wound recovery in patients with liver cirrhosis are intricately intertwined. There seems to be the substantial and intricate relationship between stress, mental health and wound recovery. The results of this study supported the notion that psychological evaluation and support should be incorporated into the management of patients with liver cirrhosis.
Solid state synthesis of BiFeO3 occurs through the intermediate Bi25FeO39 compound
Authors: Wesley Corrado , Bellcase Leah , Forrester Jennifer S. , Dickey Elizabeth C. , Reaney Ian M. , Jones Jacob L. 
Published: February 2024

AbstractThe solid‐state synthesis of perovskite BiFeO3 has been a topic of interest for decades. Many studies have reported challenges in the synthesis of BiFeO3 from starting oxides of Bi2O3 and Fe2O3, mainly associated with the development of persistent secondary phases such as Bi25FeO39 (sillenite) and Bi2Fe4O9 (mullite). These secondary phases are thought to be a consequence of unreacted Fe‐rich and Bi‐rich regions, that is, incomplete interdiffusion. In the present work, in situ high‐temperature X‐ray diffraction is used to demonstrate that Bi2O3 first reacts with Fe2O3 to form sillenite Bi25FeO39, which then reacts with the remaining Fe2O3 to form BiFeO3. Therefore, the synthesis of perovskite BiFeO3 is shown to occur via a two‐step reaction sequence with Bi25FeO39 as an intermediate compound. Because Bi25FeO39 and the γ‐Bi2O3 phase are isostructural, it is difficult to discriminate them solely from X‐ray diffraction. Evidence is presented for the existence of the intermediate sillenite Bi25FeO39 using quenching experiments, comparisons between Bi2O3 behavior by itself and in the presence of Fe2O3, and crystal structure examination. With this new information, a proposed reaction pathway from the starting oxides to the product is presented.
The inseparability of context and clinical reasoning
Authors: Olson Andrew , Kämmer Juliane E. , Taher Ahmed , Johnston Robert , Yang Qian , Mondoux Shawn , Monteiro Sandra 
Published: February 2024

AbstractEarly descriptions of clinical reasoning have described a dual process model that relies on analytical or nonanalytical approaches to develop a working diagnosis. In this classic research, clinical reasoning is portrayed as an individual‐driven cognitive process based on gathering information from the patient encounter, forming mental representations that rely on previous experience and engaging developed patterns to drive working diagnoses and management plans. Indeed, approaches to patient safety, as well as teaching and assessing clinical reasoning focus on the individual clinician, often ignoring the complexity of the system surrounding the diagnostic process. More recent theories and evidence portray clinical reasoning as a dynamic collection of processes that takes place among and between persons across clinical settings. Yet, clinical reasoning, taken as both an individual and a system process, is insufficiently supported by theories of cognition based on individual clinicals and lacks the specificity needed to describe the phenomenology of clinical reasoning. In this review, we reinforce that the modern healthcare ecosystem – with its people, processes and technology – is the context in which health care encounters and clinical reasoning take place.
The clinical use of personal hearing amplifiers in facilitating accessible patient–provider communication: A scoping review
Authors: Koerber Raphaelle M. , Kokorelias Kristina M. , Sinha Samir K. 
Published: February 2024

AbstractBackgroundOlder adults with hearing loss struggle to communicate with care providers and experience higher mortality rates when hospitalized (Genther et al., 2015), even after controlling for age and comorbidities. Personal hearing amplifiers (PHAs), (e.g., Pocketalkers™), can improve communication with older patients.MethodsWe conducted a scoping review to identify research gaps and summarize findings on the clinical use of PHAs with patients with hearing loss. After refining search terms relating to hearing loss and PHAs, we searched MEDLINE, Embase, PsycINFO, Cochrane Library, CINAHL Complete, Web of Science Core Collection, ERIC (Proquest), PubMed, ClinicalTrials.gov, International Clinical Trials Registry Platform, and the International Standard Randomised Controlled Trial Number Registry. We identified articles published in English between 1980 and 2022 that reported empirical outcomes relating to PHA use in clinical settings. Two reviewers independently extracted data from articles. We then organized data into an evidence map, and a narrative review summarizing outcomes.ResultsFrom 4234 initially identified titles and abstracts, 12 met our criteria as full texts. These included three surveys on clinicians' awareness and use of PHAs, one evaluation of the acoustic output of a PHA, and eight interventions wherein PHAs were provided to patients with hearing loss. These papers used 10 different terms for PHAs and largely did not cite one another. Results showed high levels of satisfaction with PHAs, and consistently improved speech understanding. Despite this, care providers used devices inconsistently, with challenges around provider awareness, and device maintenance and location tracking.ConclusionsPHAs have a consistent positive effect on patients' ability to understand their care providers despite hearing loss. Barriers and facilitators to their use in clinical settings should be further explored.
TWEAK levels in psoriatic patients treated with narrowband ultraviolet B and methotrexate
Authors: Hegazy Eisa Mohamed , El Taieb Moustafa A. , Ibrahim Hassan Mohamed , Rageh El‐Hassan M. , Ahmed Nour Mohammed , Ibrahim Ahmed K. , Younis Ali Mohamed , Ali Mahmoud Ahmed 
Published: February 2024

AbstractBackgroundPsoriasis is an autoimmune disease which has an effect on the joints and skin. Tumor Necrosis Factor‐Like Weak Inducer of Apoptosis (TWEAK) is a multi‐functional cytokine which regulates the cellular processes and has been related to a variation of conditions.ObjectivesTo measure the level of serum TWEAK in psoriatic diseased persons and its relationship to the PASI score pre‐ and post‐therapy with narrowband ultraviolet B phototherapy (NB‐UVB) and methotrexate (MTX).MethodsThis randomized controlled trial was conducted on 40 patients and 20 healthy persons as controls. Patient Group was randomly subdivided to two groups. The 1st group consisted of 20 patients who received NB‐UVB treatment. The 2nd group included 20 MTX‐treated candidates. Blood samples were drawn from patients in order to detect serum TWEAK levels using ELISA. The research was registered on Clinical Trials Registration: RCT approval numbers: NCT0481191.ResultsThe mean PASI score percent improvement after 12 weeks of treatment was higher in the MTX group (90%) than NB‐UVB group (60%). The serum TWEAK level at baseline was 60.47 ± 12.6 pg/mL in NB‐UVB group and 54.69 ± 21.7 pg/mL in MTX group which reduced to 24.93 ± 17.6 pg/mL and 32.13 ± 23.6 pg/mL, respectively (p < 0.001), after 12 weeks of treatment. There was a positive correlation between the serum levels of TWEAK and severity of PASI score (r = 0.399, p = 0.014).ConclusionTWEAK grades in psoriasis are substantially higher than in controls. TWEAK levels were dramatically reduced during NB‐UVB and MTX treatment. TWEAK may have a potential sign for psoriasis diagnosis and prognosis.
Deep reinforcement learning‐based active mass driver decoupled control framework considering control–structure interaction effects
Authors: Yao Hongcan , Tan Ping , Yang T. Y. , Zhou Fulin 
Published: February 2024

AbstractControl–structure interaction (CSI) plays a significant role in active control systems. Popular methods incorporate actuator dynamics into an integrated control system to account for CSI, leading to a situation where existing structural control algorithms that ignore CSI cannot be applied directly. To address this issue, this study proposes a deep reinforcement learning (DRL) based active mass driver (AMD) decoupled control framework, in which a structural control algorithm is employed to generate the control force command without consideration of CSI, while a DRL agent is utilized to attenuate the CSI effects of AMD systems and achieve a desired control force. The DRL‐based AMD control framework is verified through a series of numerical experiments. Furthermore, the applicability of the control framework is confirmed in a wind‐excited 76‐story benchmark building. Comprehensive analysis indicates that the proposed control framework can effectively eliminate the CSI effects and apply accurate control force to the structure in various scenarios, which allows for an ideal structural response control.
Obesity is associated with higher prevalence of gastroesophageal reflux disease and reflux related complications: A global healthcare database study
Authors: Xie Mengdan , Deng Lifu , Fass Ronnie , Song Gengqing 
Published: February 2024

AbstractBackgroundPrior studies have demonstrated that obesity may be associated with the development of gastroesophageal reflux disease (GERD) and GERD‐related complications. However, such association has never been assessed in a global‐wide real‐world patient population.MethodsThe TriNetX electronic health records network, which involves 92 healthcare organizations in 12 countries, was utilized for this multicenter global health research network study. The cohort with obesity comprised adult patients with body mass index (BMI) of more than 30 kg/m2. We performed 1:1 propensity score matching to decrease confounders effects. The prevalence of GERD and GERD‐related complications including erosive esophagitis, Barrett's esophagus (BE), BE with dysplasia, and esophageal adenocarcinoma were assessed.ResultsA total of 2,356,548 patients were included in the obesity and non‐obesity groups after propensity score matching. In the group with obesity, patients had a significantly higher prevalence of GERD (30% vs. 24%, OR 1.35, 95% CI 1.34–1.36) compared to the group without obesity. Further analysis showed a higher prevalence of GERD‐related complications in the group with obesity with statistical significance: Erosive esophagitis (OR 1.07, 95% CI 1.05–1.08), Barrett's esophagus (1.08, 1.05–1.10), BE with dysplasia (1.11, 1.04–1.18), esophageal cancer (1.32, 1.15–1.51).ConclusionGlobally, obesity was associated with a higher prevalence of GERD and GERD‐related complications.
Correlation analysis of airway‐facial phenotype in Crouzon syndrome by geometric morphometrics: A promising method for non‐radiation airway evaluation
Authors: Zhong Yehong , Chen Zhewei , Li Binghang , Ma Hengyuan , Yang Bin 
Published: February 2024

AbstractAimThis study aimed to verify the correlation of the airway‐facial phenotype and visualize the morphological variation in Crouzon syndrome patients. Additionally, to develop a non‐radiation methodology for airway assessments.MethodIn this study, 22 patients diagnosed with Crouzon syndrome (Age: 7.80 ± 5.63 years; Gender distribution: 11 females and 11 males) were analysed. The soft tissue surface and airway were three‐dimensionally reconstructed, and the entire facial phenotype was topologized and converted into spatial coordinates. Geometric morphometrics was employed to verify the correlation and visualize dynamic phenotypic variation associated with airway volume. A total of 276 linear variables were automatically derived from 24 anatomical landmarks, and principal component analysis (PCA) identified the 20 most significant parameters for airway evaluation. Correlation analyses between parameters and airway volume were performed. Then, patients were classified into three groups based on airway volume, and the differences among the groups were compared for evaluating the differentiating effectiveness of parameters.ResultsThe facial phenotype was strongly correlated with the airway (coefficient: 0.758). Morphological variation was characterized by (i) mandibular protrusion and anticlockwise rotation; (ii) midface retrusion; (iii) supraorbital frontward and (iv) lengthening of the facial height. All the anthropometric parameters were strongly associated with the airway, and the differences among the groups were statistically significant.ConclusionThis study confirmed the strong correlation between facial phenotype and airway parameters in Crouzon syndrome patients. Despite the development of the airway, pathological midface retrusion was still aggravated, suggesting that surgical intervention was inevitable. Three‐dimensional facial anthropometry has potential as a non‐radiation examination for airway evaluation.