bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of carcinoma of the papilla of Vater associated with a hyperplasia–dysplasia–carcinoma sequence by pancreaticobiliary maljunction
Authors: Korai Takahiro , Kimura Yasutoshi , Watanabe Kazunori , Low Siew-Kee , Imamura Masafumi , Nagayama Minoru , Kukita Kazuharu , Murakami Takeshi , Kato Toru , Kondo Yuta , Kyuno Daisuke , Sugawara Taro , Murota Ayako , Kawakami Yujiro , Masaki Yoshiharu , Nakase Hiroshi , Takemasa Ichiro 
Published: February 2024

Abstract
Background
Pancreaticobiliary maljunction (PBM) is a known risk factor for biliary tract cancer. However, its association with carcinoma of the papilla of Vater (PVca) remains unknown. We report a case with PVca that was thought to be caused by the hyperplasia–dysplasia–carcinoma sequence, which is considered a mechanism underlying PBM-induced biliary tract cancer.

Case presentation
A 70-year-old woman presented with white stool and had a history of cholecystectomy for the diagnosis of a non-dilated biliary tract with PBM. Esophagogastroduodenoscopy revealed a tumor in the papilla of Vater, and PVca was histologically proven by biopsy. We finally diagnosed her with PVca concurrent with non-biliary dilated PBM (cT1aN0M0, cStage IA, according to the Union for International Cancer Control, 8th edition), and subsequently performed subtotal stomach-preserving pancreaticoduodenectomy. Pathological findings of the resected specimen revealed no adenomas and dysplastic and hyperplastic mucosae in the common channel slightly upstream of the main tumor, suggesting a PBM related carcinogenic pathway with hyperplasia–dysplasia–carcinoma sequence. Immunostaining revealed positivity for CEA. CK7 positivity, CK20 negativity, and MUC2 negativity indicated that this PVca was of the pancreatobiliary type. Genetic mutations were exclusively detected in tumors and not in normal tissues, and bile ducts from formalin-fixed paraffin-embedded samples included mutated-ERBB2 (Mutant allele frequency, 81.95%). Moreover, of the cell-free deoxyribonucleic acid (cfDNA) extracted from liquid biopsy mutated-ERBB2 was considered the circulating-tumor deoxyribonucleic acid (ctDNA) of this tumor.

Conclusions
Herein, we report the first case of PVca with PBM potentially caused by a “hyperplasia–dysplasia–carcinoma sequence” detected using immunostaining and next-generation sequencing. Careful follow-up is required if pancreaticobiliary reflux persists, considering the possible development of PVca.
A case of fat-forming solitary fibrous tumor that is prone to be confused with liposarcoma
Authors: Ma Yi-Dan , Wu Zi-Qing , Liang Xin-Rong , Pi Lin Jing , Gong Meng-Zhen , Tang Yao 
Published: February 2024

AbstractFat-forming solitary fibrous tumor is a rare and specific subtype of solitary fibrous tumor. In this case, a mass of 8.3 cm in diameter was found in a 59-year-old male patient’s right retroperitoneum, as revealed by abdominal contrast-enhanced computed tomography (CT) images. The tumor exhibited a well-circumscribed nature and histological features characterized by a combination of hemangiopericytomatous vasculature and mature adipose tissue, comprising around 70% of the total tumor composition. Immunohistochemistry staining revealed diffuse positive expression of STAT6 and CD34 in the tumor cells. Based on these findings, the final diagnosis was determined to be a fat-forming solitary fibrous tumor located in the retroperitoneum. It is important to consider other potential differential diagnoses, including angiomyolipoma, dedifferentiated liposarcoma, spindle cell lipoma, and atypical lipomatous tumor/well-differentiated liposarcoma.
Resection of hypertrophic papillary muscles and mitral valve replacement in a patient with midventricular hypertrophic obstructive cardiomyopathy – a new approach
Authors: Berg Julian J. , Eckstein Jan , Deutsch Marcus-André , Gummert Jan F. , Hata Masatoshi 
Published: February 2024

AbstractMidventricular hypertrophic obstructive cardiomyopathy (HOCM) is characterized by hypertrophy of the interventricular septum (IVS) and - in rare cases - of the papillary muscles (PM), which subsequently can cause dynamic left ventricular outflow tract obstruction (LVOTO) and severe heart failure symptoms. We report on a rare case of a 44-year-old patient suffering from midventricular HOCM with hypertrophic anterolateral PM and an additional chorda between the PM and the IVS.We describe a new surgical approach via right anterolateral thoracotomy in 3-dimensional (3D) video-assisted minimal-invasive technique with resection of hypertrophic PMs as well as the entire mitral valve-apparatus and valve replacement avoiding septal myectomy and potentially associated complications. After an uneventful procedure clinical symptoms improved from NYHA III-IV at baseline to NYHA 0-I postoperatively and remained stable over a follow-up period of 24 months. Therefore, the presented technique may be considered as a new and alternative approach in patients with hypertrophic PMs and hypertrophic IVS as subtype of midventricular HOCM.
Effects of Pilates exercises on spine deformities and posture: a systematic review
Authors: Li Fangyi , Omar Dev Roxana Dev , Soh Kim Geok , Wang Chen , Yuan Yubin 
Published: February 2024

Abstract
Background
Pilates is becoming increasingly popular amongst a wide range of people and is gaining more attention. It is also an effective means of physical rehabilitation. The aim of this systematic review is to explore the effects of Pilates on spinal deformity and posture.

Method
This systematic review was conducted using four recognised academic and scientific databases (Scopus, Web of Science, PubMed and Cochrane) to identify articles that met the inclusion criteria. The secondary search used the Google Scholar and the Science Direct search engines. The search for articles for this review began in July 06, 2023 and was concluded on February 01, 2024. The search process for this study was documented using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020). The PEDro scale was used to assess the internal validity and data statistics of the studies included in this systematic review and to evaluate the quality of the studies.

Results
The systematic review included nine studies that met the inclusion criteria from the 651 studies retrieved, involving a total of 643 participants. The PEDro scale scores of the studies included in this systematic review ranged from 3 to 8. The intervention was in the form of Pilates or Pilates combined exercises. The studies included in this review used outcome measures of Cobb angle, angle of trunk rotation (ATR), range of motion (ROM), chest expansion, Scoliosis Research Society Questionnaire (SRS-22r) and postural assessment. Research has shown that Pilates is effective in correcting spinal deformities and posture, as well as improving quality of life, pain relief, function and fitness.

Conclusions
This systematic review provide substantial evidence that Pilates has a positive impact on improving spinal deformity and posture. However, more research is needed to validate whether Pilates can be used effectively as a physical therapy for spinal deformity rehabilitation. Pilates has considerable potential for public health interventions.
Evaluation of Pathway to Diagnosis of Pediatric Brain Tumors in Tamil Nadu, India
Authors: Kartik Prerna , Liu Jo-Fen , Sudarsan Rishan Thimma , Srinivasan Aarthi , Jayaraman Dhaarani , Sivaprakasam Ponni , John Rikki , Uppuluri Ramya , Scott Julius Xavier , Jalali Rakesh , Dandapani Madhumita 
Published: February 2024

PURPOSE Delayed diagnosis and poor awareness are significant barriers to the early intervention of pediatric brain tumors. This multicenter observational study aimed to evaluate the baseline routes and time to diagnosis for pediatric brain tumors in Tamil Nadu (TN), with the goal of promoting early diagnosis and timely referrals in the future. METHODS A standard proforma was used to retrospectively collect information on demographics, diagnosis, referral pathways, and symptoms of incident pediatric brain tumor cases between January 2018 and October 2020 across eight tertiary hospitals in TN. Dates of symptom onset, first presentation of health care, and diagnosis were used to calculate total diagnostic interval (TDI), patient interval (PI), and diagnostic interval (DI). RESULTS A total of 144 cases (mean age, 6.64 years; range, 0-15.1 years) were included in the analysis. Among those, 94% (135/144) were from city/district areas, 40% (55/144) were self-referred, and 90% (129/144) had one to three health care professional visits before diagnosis. Median TDI, PI, and DI were 3.5 (IQR, 1-9.3), 0.6 (IQR, 0.1-4.6), and 0.6 (IQR, 0-3.3) weeks, respectively. Low-grade gliomas had the longest median TDI (6.6 weeks), followed by medulloblastomas (4.6 weeks) and high-grade gliomas (3.3 weeks). Average number of symptoms recorded was 1.7 at symptom onset and 1.9 at diagnosis. CONCLUSION Although there are some similarities with data from the United Kingdom, many low-grade and optic pathway tumors were unaccounted for in our study. DIs were relatively short, which suggests that infrastructure may not be a problem in this cohort. Increased training and establishment of proper cancer registries, combined with proper referral pathways, could enhance early diagnosis for these children.
Characterizing the Traveling Oncology Workforce and Its Influence on Patient Travel Burden: A Claims-Based Approach
Authors: Scodari Bruno T. , Schaefer Andrew P. , Kapadia Nirav S. , O'Malley A. James , Brooks Gabriel A. , Tosteson Anna N.A. , Onega Tracy , Wang Changzhen , Wang Fahui , Moen Erika L. 
Published: February 2024

PURPOSE Oncology outreach is a common strategy for extending cancer care to rural patients. However, a nationwide characterization of the traveling workforce that enables this outreach is lacking, and the extent to which outreach reduces travel burden for rural patients is unknown. METHODS This cross-sectional study analyzed a rural (nonurban) subset of a 100% fee-for-service sample of 355,139 Medicare beneficiaries with incident breast, colorectal, and lung cancers. Surgical, medical, and radiation oncologists were linked to patients using Part B claims, and traveling oncologists were identified by observing hospital service area (HSA) transition patterns. We defined oncology outreach as the provision of cancer care by a traveling oncologist outside of their primary HSA. We used hierarchical gamma regression models to examine the separate associations between patient receipt of oncology outreach and one-way patient travel times to chemotherapy, radiotherapy, and surgery. RESULTS On average, 9,935 of 39,960 oncologists conducted annual outreach, where 57.8% traveled with low frequency (0-1 outreach visits/mo), 21.1% with medium frequency (1-3 outreach visits/mo), and 21.1% with high frequency (>3 outreach visits/mo). Oncologists provided surgery, radiotherapy, and chemotherapy to 51,715, 27,120, and 5,874 rural beneficiaries, respectively, of whom 2.5%, 6.9%, and 3.6% received oncology outreach. Rural patients who received oncology outreach traveled 16% (95% CI, 11 to 21) and 11% (95% CI, 9 to 13) less minutes to chemotherapy and radiotherapy than those who did not receive oncology outreach, corresponding to expected one-way savings of 15.9 (95% CI, 15.5 to 16.4) and 11.9 (95% CI, 11.7 to 12.2) minutes, respectively. CONCLUSION Our study introduces a novel claims-based approach for tracking the nationwide traveling oncology workforce and supports oncology outreach as an effective means for improving rural access to cancer care.
The relationship between mitochondrial respiration, resting metabolic rate and blood cell count in great tits
Authors: Thoral Elisa , García-Díaz Carmen C. , Persson Elin , Chamkha Imen , Elmér Eskil , Ruuskanen Suvi , Nord Andreas 
Published: February 2024

ABSTRACT
Although mitochondrial respiration is believed to explain a substantial part of the variation in resting metabolic rate (RMR), few studies have empirically studied the relationship between organismal and cellular metabolism. We therefore investigated the relationship between RMR and mitochondrial respiration of permeabilized blood cells in wild great tits (Parus major L.). We also studied the correlation between mitochondrial respiration traits and blood cell count, as normalizing mitochondrial respiration by the cell count is a method commonly used to study blood metabolism. In contrast to previous studies, our results show that there was no relationship between RMR and mitochondrial respiration in intact blood cells (i.e. with the ROUTINE respiration). However, when cells were permeabilized and interrelation re-assessed under saturating substrate availability, we found that RMR was positively related to phosphorylating respiration rates through complexes I and II (i.e. OXPHOS respiration) and to the mitochondrial efficiency to produce energy (i.e. net phosphorylation efficiency), though variation explained by the models was low (i.e. linear model: R2=0.14 to 0.21). However, unlike studies in mammals, LEAK respiration without [i.e. L(n)] and with [i.e. L(Omy)] adenylates was not significantly related to RMR. These results suggest that phosphorylating respiration in blood cells can potentially be used to predict RMR in wild birds, but that this relationship may have to be addressed in standardized conditions (permeabilized cells) and that the prediction risks being imprecise. We also showed that, in our conditions, there was no relationship between any mitochondrial respiration trait and blood cell count. Hence, we caution against normalising respiration rates using this parameter as is sometimes done. Future work should address the functional explanations for the observed relationships, and determine why these appear labile across space, time, taxon, and physiological state.
Use Mental Imagery Techniques to Transform Your Fitness Classes into a Fantastic Experience
Authors: Daskalaki Katerina , Papadimitriou Katerina , Malliou Paraskevi 
Published: February 2024

Apply It!
By reading this article fitness professionals will:
• Be informed of the basic concepts of mental imagery (MI).
• Learn how to use MI techniques to enhance the technique, the strategies, and the psychological states of the exercisers, adding to their exercise class’s creativity and imagination.
DIGITALIZATION IS THE ONLY WAY TO DEVELOP ROAD TRANSPORT
Authors: Izyumskiy Alexander A. , Nadiryan Sofiya L. , Kotsurba Sofiya V. 
Published: February 2024

In this article, the authors have approached the problem of introducing digitalization in the field of road transport.
The purpose of this study is an attempt to determine the features of the interaction of new digital technologies with the system of freight and passenger road transport.
During the study, the main directions of digitalization implementation in the field of road transport were identified, the existing difficulties arising during the transition from the old methods of management and control of motor transport to the new digital ones were indicated.
As a result, conclusions are drawn about the need for the early introduction of digital methods of organization and management of road transport with extensive use of artificial intelligence.
The introduction of digital methods of organizing transportation activities has broad support from both the Government of the Russian Federation and the business community of Russia. The transition to the digital economy is impossible without a primary transition in its “circulatory system” - the transport system.
AUTOMATION OF THE PROCESS OF CONVERTING CURRENCIES INTO ROUBLES ON THE BASIS OF TELEGRAM
Authors: Nazmeev Aynaz L. , Gareeva Gulnara A. , Grigoreva Diana R. , Karimullin Bulat R. , Kuznetsova Evelina M. 
Published: February 2024

This article describes the creation of a Telegram bot that will help us quickly convert any currency into rubles. The main thing for the user will be the simplicity and speed of using this bot. And to a large extent it simplifies the work for many employees who often have to convert foreign currency into rubles.
The goal is to create a convenient environment in which users can quickly and without much difficulty convert currencies into rubles.
Method or methodology of work: the article considers a method in which any user, specifying the letter code of the currency, can find out the exchange rate for today in rubles. For realization the programming language Python and programming environment PyCharm are used.
Result: a tool is developed by which the user can find out the ruble exchange rate in the selected currency.
Scope of the results: the data will be used by bank employees or any other users who are interested in the ruble exchange rate.
DATABASE DEPLOYMENT PATTERN FOR HIGH AVAILABILITY
Authors: Khamitov Renat M. 
Published: February 2024

Ubiquitous digitalization and the development of big data technologies require a high level of availability (24/7) of information resources. Ensuring high availability of the database requires a significant amount of work on the design, testing and maintenance of several components and configurations. High availability can be achieved or maximized for the following deployment options: one database instance (with or without read replicas) and several main ones (with or without a coordinator). High availability ensures the smooth operation of the system by eliminating individual points of failure, while disaster recovery focuses on restoring normal operation after a failure or downtime. There are several deployment options because there is no universal solution. Choosing the best option depends on your specific use case and requirements. This article presents the main concepts of ensuring high availability and the most effective patterns for providing highly accessible database deployments.
Purpose. definition of effective deployment patterns for database servers to ensure high availability.
Methodology. The results of foreign and domestic scientific research are used in the work. The author uses theoretical research methods related to the search and analysis of information to identify connections and obtain unique conclusions.
Results. The most effective deployment schemes for ensuring high availability and fault tolerance of databases are highlighted.
Practical implications it is advisable to apply the results obtained in the field of DevOps development in order to optimize the process of developing and releasing applications by eliminating a known bottleneck: changes to the database code.
PRACTICAL ASPECTS OF ASSESSING THE ECONOMIC SECURITY OF A TRANSPORT COMPANY
Authors: Mirkina Olga N. 
Published: February 2024

Transport is an important sector of the country’s economy. Its activities have an impact on other businesses and the public. It is important that enterprises in the transport industry achieve a state of economic security. The absence of a unified definition of the concept of “economic security” and approaches to its assessment is shown. It is noted that the concept of “financial security” is closely related to the concept of “economic security.” It has been shown that without financial security, it is impossible to achieve a state of economic security. On the example of the most important enterprise of railway transport in Russia, an assessment of the financial condition, financial security and economic security was carried out. Extremely low economic security of the enterprise was revealed. Based on the analysis, some ways have been proposed to improve the financial and economic security of the enterprise in question.
The goal is to consider practical aspects of the economic security of the transport company through an assessment of the financial and economic security of FPK JSC.
Method or methodology of work: the study used a systematic approach and general scientific methods - statistical, comparative analysis, expert assessments and logical generalizations.
Results: shows the relationship between the financial and economic security of the enterprise. The economic security of FPK JSC was assessed as extremely low. Some ways to strengthen financial and economic security have been proposed.
Field of application of the results: it is advisable to apply the obtained results to economic entities engaged in activities in the field of transport.
PROSPECTS AND POSSIBILITIES BLOCKCHAIN TECHNOLOGY APPLICATION IN LOGISTICS
Authors: Kargopolov Arseniy S. , Kripak Marina N. , Kiyashko Larisa A. 
Published: February 2024

The article discusses the problems and prospects for development of the logistics sector in Russia. The concept of blockchain, its main functions and tasks are described. The principles of operation of the system and examples of companies already using this technology are given. Now, in Russia, logistics support for cargo delivery has low quality and economic efficiency indicators. Logistics is in search of new technologies that will simplify and automate the process of accumulating and using data related to document flow, cargo tracking and information storage. Logistics chains can include dozens of links; the more nodes in the chain, the more difficult it is to control them and the more information appears. At the same time, interactions between producers, carriers and consumers are becoming less transparent. Blockchain technologies can solve these problems by reducing the cost of transportation, making information impossible to hack and falsify, and optimizing processing and query times.
Purpose: to consider the main problems and challenges arising in the field of logistics that blockchain technologies can solve.
Results: obtaining information on how blockchain technology can be applied in logistics, as well as identifying opportunities and prospects for its use.
Practical implications: deciding on the implementation of blockchain technology in logistics operations and using its advantages to assess efficiency and competitiveness.
OPTIMIZATION OF THE LEARNING PROCESS BY AUTOMATION OF OBTAINING THE SCHEDULE BASED ON TELEGRAM
Authors: Chernov Vadim A. , Fatikhov Dinar R. , Ramazanov Azat D. , Gareeva Gulnara A. 
Published: February 2024

This article describes the process of creating a Telegram bot that would automatically send class schedules for full-time/part-time students on a daily basis. A feature of Telegram bots is - simplicity of use and minimization of resources, which greatly simplifies its creation and interaction with it.
Purpose – create a convenient environment in which the student can easily get the information he or she needs, spending a minimum amount of time.
The method or methodology of the work: the article deals with the way in which by appointing the academic department as the administrator, there will be access to fill the database. Students, when starting the Telegram bot, once will need to specify the form of study and the group. To implement it, the following are used a SQLite database and the Python programming language are used in the implementation.
Result: developed a tool that automates the student will be aware of his schedule, and for the educational part it is easier to create a schedule for each group.
Scope of the results: the data stored in the database is reasonable to use to obtain information in the academic life.