bluuebunny/crossref_metadata_2025_split huggingface dataset:
VARIABLES AMBIENTALES, SENSORES REMOTOS Y SISTEMAS DE INFORMACIÓN GEOGRÁFICA APLICADOS AL ESTUDIO DE LA DISTRIBUCIÓN DE RHODNIUS PROLIXUS EN COLOMBIA
Authors: Guhl Felipe 
Published: December 2023

Utilizando la base de datos de triatominos creada a partir de la encuesta entomológica que se realizó entre los años de 1997 y 2001 por el Programa Nacional de Control de la Enfermedad de Chagas (PNCECH) y mapas con imágenes temporales satelitales de 57 variables ambientales se construyeron varios mapas predictivos de la dispersión de Rhodnius prolixus en Colombia a partir de las imágenes temporales, un análisis de Fourier y un análisis estadístico multivariado discriminante de las variables estudiadas. Los mapas muestran la dispersión de esta especie, y las posibles implicaciones de la dispersión de este triatomino en la transmisión de la enfermedad de Chagas en Colombia.
Se encontró una marcada división en la predicción de la dispersión de R. prolixus en dos zonas geográficas: una zona al sureste de la cordillera oriental, la cual está muy asociada a las variables ambientales utilizadas en el presente estudio; otra zona al este de la cordillera oriental en los valles interandinos no muy bien definida por las mismas variables, lo que supone que la zona suroccidental de Colombia es propensa a una dispersión más amplia de R. prolixus asociada a otras variables ambientales diferentes a las de la zona nororiental, en donde podría estar asociada más a las intervenciones humanas.
En esta región de los Llanos orientales, se encontraron recientemente poblaciones silvestres de R. prolixus en palmas de la especie Attalea butyracea, lo cual confirma la predicción de la presencia de esta especie en la región.
PROCESOS PARA LA CAPTURA DE CO2 . EMISIÓN DE ÓXIDOS DE NITRÓGENO Y DE AZUFRE DURANTE LA OXI- COMBUSTIÓN DE UN CARBONIZADO
Authors: Sánchez Astrid , Eddings Eric , Mondragón Fanor 
Published: December 2023

El carbón es uno de los combustibles fósiles más empleados para la producción de energía eléctrica, y para diferentes actividades industriales y domésticas. Sin embargo, el uso de este combustible genera emisiones nocivas para el ambiente; entre ellos se encuentra el CO2 , principal producto de combustión que actúa como gas de efecto invernadero. Se han estudiado diferentes procesos con el fin de disminuir la emisión de CO2 a la atmósfera, entre ellos se encuentra la oxi-combustión, que consiste en emplear una atmósfera enriquecida en O2 , con el fin de obtener una alta concentración de CO2 en los gases de combustión que facilite su separación. El incremento en la presión parcial de O2 genera cambios importantes en el ambiente químico de la combustión que afecta las reacciones de oxidación y emisión de contaminantes como SOx y NOx. En la presente investigación se encontró que en procesos de oxi-combustión, altas concentraciones de CO2 promueve la formación de NO2. Por lo tanto, es importante evaluar los efectos que tendrán estas modificaciones en el proceso global.
EL CONTEXTO DE LAS SERPIENTES DE COLOMBIA CON UN ANÁLISIS DE LAS AMENAZAS EN CONTRA DE SU CONSERVACIÓN
Authors: Lynch John D. 
Published: December 2023

La fauna de serpientes de Colombia excede las 270 especies de ellas 30 son elápidos (corales) y 19 vipéridos (cascabel & talla equis). En Colombia las serpientes están distribuidas en casi todo del territorio, excepto en las aguas del Caribe y en las tierras altas (por encima de los 3500 metros). Estos animales son cruciales para el buen funcionamiento del ecosistema pero sufren mucho por las actividades humanas. Se han identificado cinco amenazas en contra de las serpientes: (1) destrucción por parte de campesinos y otros trabajadores del campo; (2) mortalidad vehicular sobre las carreteras; (3) mortalidad asociada con la destrucción de su hábitat, causada por los cambios climáticos locales y/o la eliminación de las presas de las serpientes; (4) el trafico ilegal de fauna; y (5) la recolección científica. Se presenta un análisis de cada amenaza con fines de calificarlas. Las estimaciones de la mortalidad de serpientes, y las calificaciones de las amenazas, basadas en la bibliografía científica y por conocimiento de la biología de los organismos, son: (1) un mínimo de 109 millones por año; (2) entre los 52,000 y los 105,000 por año; (3) un mínimo de 124 millones por año; (4) entre 1000 y 5000 por año; y (5) entre 300 y 500 por año, respectivamente. Confrontando estas cifras es necesaria una revisión profunda de los reglamentos y una re-orientación de fuerzas de las autoridades competentes que tienen la responsabilidad de cuidar los recursos naturales del país. Dos amenazas (1 y 3) son particularmente alarmantes mientras las otras tres son triviales.
Equality bodies in the European Union: The Spanish independent authority for equal treatment
Authors: Solanes Corella Ángeles 
Published: December 2023

The preceding two decades have been characterized by the evolution of equality bodies at the domestic level. Recently, several propositions have been advanced with the aim of instituting minimal prerequisites for the functioning of equality entities, aimed at enhancing their efficacy and ensuring their independence, thus fortifying the enforcement of the principle of equal treatment. In Spain, Law 15/2022 has provided for the creation of the Independent Authority for Equal Treatment and Non-Discrimination, but after the six months established for its configuration, it has not been set up. This work critically examines the proposed reforms within the Equality Directives concerning these bodies and their implementation in the case of Spain. At the same time, it assesses, from a proactive perspective, how to develop European standards in line with the proposal, so that equality bodies can deploy their full potential.Received: 15 May 2023 Accepted: 06 November 2023
Understanding Syringomyelia in Myelomeningocele: A Clinical Observational Study.
Authors: Spezzani Chiara , Di Rita Andrea , Noris Alice , Peraio Simone , Lenge Matteo , Appleton Tayler B. , Menegatti Marta , Mantovani Giorgio , D’Incerti Ludovico , Taverna Maria , Giordano Flavio 
Published: December 2023

Background: Myelomeningocele (MMC) is the most common open spinal dysraphism (OSD) and is typically associated with other clinical and/or radiological abnormalities. Chiari type 2 malformation (CM-II) is observed in 80% to 96.7% of patients, and approximately 80% of cases involve posterior fossa abnormalities leading to hydrocephalus. MMC patients can present with syringomyelia, which usually improves by treating hydrocephalus. However, a minority of patients develop a progressive form of syringomyelia requiring more invasive treatments. Through this retrospective observational study, our objective is to elucidate the incidence of syringomyelia, its symptomatic manifestations, and the associated radiological and clinical characteristics in pediatric patients diagnosed with myelomeningocele

Methods: A retrospective analysis was conducted on the medical records of 39 pediatric patients diagnosed with myelomeningocele at a tertiary referral institute. The study encompassed individuals born between 1997 and 2022. Descriptive statistics were employed to explore epidemiological aspects and clinical features. Additionally, incidence rates of syringomyelia and its progressive variants were calculated, with a focus on their correlation with diagnoses of hydrocephalus, Chiari type 2 malformation (CM-II), and spinal cord tethering.
Results: Over the last twenty-five years, the incidence of syringomyelia in pediatric patients affected by MMC was 46.2%. The incidence of its progressive forms was 16.7%. Two patients improved after the management of hydrocephalus with secondary Endoscopic Third Ventriculostomy (ETV), and only one patient required syrinx-shunting.
Conclusions: The occurrence of syringomyelia among patients with myelomeningocele (MMC) in our center aligns with reported rates in existing literature. Our findings indicate that active hydrocephalus, leading to a deterioration of hindbrain herniation, appears to be a significant factor in the development of progressive symptomatic syringomyelia within this population.
Make A Match Model: An Effort to Enhance Problem-Solving and Mathematical Representation Skills
Authors: Anggoro Bambang Sri , Putra Fredi Ganda , Pupiyanti Ika 
Published: December 2023

<p>This study aims to assess the impact of the "Make A Match" learning model on improving problem-solving abilities and mathematical representation among middle school students. Conducted at Mesuji Raya State Junior High School, this quasi-experimental study focused on the entire eighth-grade student body. A sample of 42 students was selected via cluster random sampling. Data analysis was performed using the Manova test with a significance level of 5%. The findings indicate a rejection of H0<sub>AB</sub>, suggesting a significant influence of the "Make A Match" learning model on enhancing students' problem-solving and mathematical representation abilities. These findings suggest that the "Make A Match" model can be an effective tool in aiding middle school students to improve their mathematical skills. This provides valuable insights for educators in developing learning strategies.</p><p> </p><p>Kemampuan pemecahan masalah dan representasi matematis adalah keterampilan kunci bagi siswa di tingkat sekolah menengah pertama. Meskipun penting, menemukan metode pembelajaran yang efektif untuk meningkatkan keterampilan ini sering kali menantang. Penelitian ini bertujuan untuk mengevaluasi efektivitas model pembelajaran <em>make a match</em> dalam meningkatkan kemampuan pemecahan masalah dan representasi matematis di kalangan siswa SMP. Menggunakan metode quasi eksperimen, penelitian ini dilaksanakan di SMP Negeri 1 Mesuji Raya. Target populasi adalah seluruh siswa kelas VIII, dengan sampel sejumlah 42 siswa yang dipilih melalui cluster random sampling. Analisis data dilakukan menggunakan Uji Manova dengan tingkat signifikansi 5%. Hasil penelitian menunjukkan bahwa H0AB ditolak, mengindikasikan bahwa model pembelajaran Make A Match berpengaruh signifikan terhadap peningkatan kemampuan pemecahan masalah dan representasi matematis siswa. Temuan ini menyarankan bahwa model Make A Match dapat menjadi alat yang efektif untuk membantu siswa SMP dalam meningkatkan keterampilan matematika mereka, memberikan wawasan berharga bagi para pendidik dalam pengembangan strategi pembelajaran.</p>
A study of intersphincteric resection rate following robotic-assisted total mesorectal excision versus laparoscopic-assisted total mesorectal excision for patients with middle and low rectal cancer: Study protocol for a multicenter randomized clinical trial
Authors: Guo Yuchen , He Liang , Tong Weidong , Chi Zhaocheng , Ren Shuangyi , Cui Binbin , Wang Quan 
Published: December 2023

Abstract

Introduction: Robotic-assisted complete mesorectal excision (RATME) is increasingly being used by colorectal surgeons. Most surgeons consider RATME a safe method, and believe it can facilitate total mesorectal excision (TME) in rectal cancer, and may potentially have advantages over intersphincteric resection (ISR) and anus preservation. Therefore, this trial was designed to investigate whether RATME has technical advantages and can increase the ISR rate compared with laparoscopic-assisted TME (LATME) in patients with middle and low rectal cancer.
Methods and analysis: This is a multicenter, superiority, randomized controlled trial designed to compare RATME and LATME in middle and low rectal cancer. The primary endpoint is the ISR rate. The secondary endpoints are coloanal anastomosis (CAA) rate, conversion to open surgery, conversion to transanal TME (TaTME), abdominoperineal resection (APR) rate, postoperative morbidity and mortality within 30 days, pathological outcomes,long-term survival outcomes, functional outcomes,and quality of life. In addition, certain measurements will be conducted to ensure quality and safety, including centralized photography review and semiannual assessment.
Discussion: This trial will clarify if RATME improves ISR and promotes anus preservation in patients with mid- and low-rectal cancer. Furthermore, this trial will provide evidence on the optimal treatment strategies for RATME and LATME in patients with mid- and low-rectal cancer regarding improved operational safety.
Trial registration: The trial has been registered on ClinicalTrials.gov website, NCT06105203.
Hypertension versus diabetes in patients with alcohol use disorder: a randomized controlled trial
Authors: Tseng Pei-Ying , Sung Fung-Chang , Muo Chih-Hsin , Lan Yu-Ching , Hser Yih-Ing , Chien Sarina Hui-Lin , Wang Jong-Yi 
Published: December 2023

Abstract
Background
A population-based follow-up study assessing the risk of developing hypertension and diabetes mellitus (DM) associated with alcohol use disorder (AUD) is crucial. We investigated this relationship by using insurance claims data from Taiwan.
Methods
From the claims data, an AUD cohort (N = 60,590) diagnosed between 2000 and 2006 and a non-AUD comparison cohort (N = 60,590) without the diagnosis of hypertension or DM at baseline were established and matched by propensity scores estimated by baseline demographic status and the Charlson comorbidity index (CCI). We assessed the incidence rates of hypertension and/or diabetes at the end of 2016 and used Cox’s method to estimate the related hazard ratios (HRs) and 95% confidence intervals (CIs).
Results
Relative to the comparison cohort, the AUD cohort had an approximately 1.70-fold higher incidence of hypertension (35.1 vs. 20.7 per 1,000 person-years), with an adjusted HR (aHR) of 1.72 (95% CI: 1.68–1.76), 2.16-fold higher incidence of diabetes (20.2 vs. 9.36 per 1,000 person-years), with an aHR of 2.18 (95% CI: 2.11–2.24), and 1.91-fold higher incidence of both DM and hypertension (10.3 vs. 5.38 per 1,000 person-years) with an aHR of 2.02 (95% CI: 1.94–2.10). The incidence rates of all outcomes were greater in men than in women, whereas the HRs were greater for AUD in women than for AUD in men relative to the respective comparison patients. The risk increased further for subjects with CCI ≥ 1, which was higher in the AUD cohort.
Conclusions
The increased risk of developing DM and hypertension in patients with AUD indicates that clinicians should address potential comorbidities in these patients.
Efficient evidence-based selection for clinical researchers in Traditional Chinese Medicine
Authors: Li Yizhen , Huang Zhe , Luan Zhongzhi , Xu Shujing , Zhang Yunan , Wu Lin , Wu Darong , Han Dongran , Liu Yixing 
Published: December 2023

Abstract

Purpose: Searching and selecting clinical evidence for systematic reviews (SRs) or clinical guidelines are vital for researchers in traditional Chinese medicine (TCM). The process can be time-consuming and resource-intensive, requiring significant effort from researchers. In this study, we introduce a new method for evidence-based selection that combines artificial intelligence (AI) and human efforts to achieve both swift and precise for TCM practitioners.
Methods: We use the knowledge engineer (KE) approach and a series of Boolean logic codes to select potential evidence automatically and accurately, with minimal human intervention. The selection details are recorded in real-time, enabling researchers to backtrack and verify the accuracy of the selection process. We apply the new approach in ten high-quality systematic reviews of randomly selected with TCM topics in the Chinese language. To evaluate the method's effectiveness, we compare the screen time and accuracy of the traditional selection method with the new process.
Results: The results show that the new method can accurately select potential literature under the same criteria while taking less time. Moreover, the new approach can identify more related evidence literature in some cases while tracking the selection progress for future reference. This study also identifies traditional screening methods are subjective and may lead to error inclusion of literature that does not meet the standards. The new method provides a more accurate and efficient way to select potential clinical evidence for TCM practitioners, outperforming traditional methods that rely solely on human effort.
Conclusion: We offer a novel approach to select clinical evidence for reviews and guidelines in TCM that can significantly reduce the workload for researchers. Our method holds promise for improving the efficiency and accuracy of evidence-based selection and may be used by editors to check the quality of manuscripts in the future.
The Prognostic Value of LAYN in HPV-related head and neck squamous cell carcinoma and its Influence on Immune Cell Infiltration
Authors: Chen Qingjuan , Chen Jiankang , Lu Zuzhuang , Nian Rui , Li Wanjun , Yao Zhongqiang , Mou Shangdong , Liu Ying , Cao Xia , He Wenjing , ZHU Chenjing 
Published: December 2023

Abstract
Background
HPV-positive head and neck squamous cell carcinoma (HNSCC) exhibits different characteristics from HPV-negative tumors in terms of tumor development, clinical features, treatment response, and prognosis. Layilin (LAYN), which contains homology with C-type lectins, plays a critical role in tumorigenesis and cancer progression. However, the prognostic value of LAYN and the relationship between LAYN and immune infiltration levels in HPV-related HNSCC patients still require a comprehensive understanding. Herein, we aimed to assess the prognostic value of LAYN and to investigate its underlying immunological function in HPV-related HNSCC.
Methods
Through various bioinformatics methods, we analyzed the data from The Cancer Genome Atlas (TCGA), Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA) databases to explore the potential underlying oncogenic impression of LAYN, including the relevance of LAYN to survival outcomes, clinicopathological factors, immune cell infiltration, and immune marker sets in HPV-related HNSCC. The expression levels of LAYN and HPV were also verified in HNSCC patient tissues.
Results
LAYN was differentially expressed in a variety of tumors. The expression of LAYN in HNSCC was significantly higher than that in adjacent normal tissues (P < 0.0001), and high expression of LAYN was correlated with poor overall survival (OS) in HNSCC patients (Hazard Ratio (HR) = 1.3, P = 0.035). Moreover, LAYN expression level in HPV-positive HNSCC patients was significantly lower than that in HPV-negative patients, with HPV-positive HNSCC patients displaying a trend of favorable prognosis. In addition, the relationship between LAYN expression and immune infiltration levels in HPV-positive HNSCC group was less tightly correlated than that in HPV-negative HNSCC group, and there was a strong relationship between LAYN expression and markers of M2 macrophage (P < 0.001) and exhausted T cells (P < 0.05) in HPV-negative HNSCC. Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis suggested that LAYN potentially influenced tumor progression through HPV infection and other cancer-related pathways.
Conclusions
LAYN might contribute to tumorigenesis via its positive correlation with immune checkpoint molecules and tumor-associated macrophages (TAMs). Our study might provide a novel prognostic biomarker and latent therapeutic target for the treatment of HPV-related HNSCC.
Health professionals’ experiences and views on obstetric ultrasound in Tanzania: A cross-sectional study
Authors: Bergström Cecilia , Ngarina Matilda , Abeid Muzdalifat , Kidanto Hussein , Edvardsson Kristina , Holmlund Sophia , Small Rhonda , Sengoma Jean Paul Semasaka , Ntaganira Joseph , Lan Pham Thi , Mogren Ingrid 
Published: December 2023

Abstract
Background
Obstetric ultrasound has been suggested to play an important role in increasing antenatal care attendance in low-income countries. The overall aim of this study was to explore health professionals’ perspectives on different aspects of obstetric ultrasound in Tanzania. More specifically, we wanted to investigate self-reported skills in performing ultrasound examinations and what health professionals thought could improve access to and utilisation of obstetric ultrasound in the clinical setting.
Material and Methods
Data collection took place between November and December 2017 using a questionnaire based on previous qualitative research results from the CROss Country UltraSound Study (CROCUS Study). In total, 17 healthcare facilities from national, regional and district levels, in five urban and semiurban municipalities in the Dar-es-Salaam region were included. A total of 636 health professionals participated in the study (physicians, n=307 and midwives/nurses, n=329).
Results
Most health professionals in this study agreed or strongly agreed that obstetric ultrasound was decisive in the clinical management of pregnancy. Compared to midwives/nurses, a greater proportion of physicians rated their skills as intermediate or high regarding basic ultrasound examinations. Most health professionals reported no skills or low-level skills for assessing cervical length, the fetal heart: 4 chamber view, aorta, and pulmonary artery, and Doppler: umbilical artery. Access to and utilisation of obstetric ultrasound was generally believed to be improved with more and better ultrasound machines along with more training. Compared to midwives/nurses, physicians were significantly more likely to agree or strongly agree that utilisation would improve however, with more ultrasound machines (OR 2.13; 95% CI 1.26 – 3.61), better quality of ultrasound machines (OR 2.27; 95% CI 1.10 – 4.69), more training for health professionals currently performing ultrasound (OR 2.11; 95% CI 1.08 – 4.17), and more physicians trained in ultrasound (OR 2.51; 95% CI 1.30 – 4.87).
Conclusions
Provision of obstetric ultrasound examinations in Tanzania would likely improve with more and better-quality ultrasound machines, more training for health professionals currently performing ultrasound, and overall, more physicians trained in ultrasound use. To increase the accessibility and utilisation of obstetric ultrasound in maternity care in Tanzania, training for midwives in basic obstetric ultrasound use is warranted.
Development of a Kidney Microphysiological System Hardware Platform for Microgravity Studies
Authors: Yeung Catherine , Jones-Isaac Kendan , Lindberg Kevin , Yang Jade , Bain Jacelyn , Ruiz Micaela , Koenig Greta , Koenig Paul , Countryman Stefanie , Himmelfarb Jonathan , Kelly Edward 
Published: December 2023

Abstract

Study of the physiological effects of microgravity on humans is limited to non-invasive testing of astronauts. Microphysiological models of human organs recapitulate many functions and disease states. Here we describe the development of an advanced, semi-autonomous hardware platform to support kidney microphysiological model experiments in microgravity.