bluuebunny/crossref_metadata_2025_split huggingface dataset:
A MULTILINGUAL APPROACH TO TASK-ORIENTED MAN-MACHINE DIALOGUE BY VOICE
Authors: MORIN PHILIPPE , HATON JEAN-PAUL , PIERREL JEAN-MARIE , RUSKE GUENTHER , WEIGEL WALTER 
Published: November 2004

In the framework of man-machine communication, oral dialogue has a particular place since human speech presents several advantages when used either alone or in multimedia interfaces. The last decade has witnessed a proliferation of research into speech recognition and understanding, but few systems have been defined with a view to managing and understanding an actual man-machine dialogue. The PARTNER system that we describe in this paper proposes a solution in the case of task oriented dialogue with the use of artificial languages. A description of the essential characteristics of dialogue systems is followed by a presentation of the architecture and the principles of the PARTNER system. Finally, we present the most recent results obtained in the oral management of electronic mail in French and German.
Relationship between hydrogel spacer distribution and dosimetric parameters in linear‐accelerator‐based stereotactic body radiotherapy for prostate cancer
Authors: Ohira Shingo , Yamashita Hideomi , Minamitani Masanari , Sawayanagi Subaru , Ogita Mami , Imae Toshikazu , Katano Atsuto , Nozawa Yuki , Ohta Takeshi , Nawa Kanabu , Nishio Teiji , Koizumi Masahiko , Nakagawa Keiichi 
Published: February 2024

AbstractPurposeTo explore the potential of quantitative parameters of the hydrogel spacer distribution as predictors for separating the rectum from the planning target volume (PTV) in linear‐accelerator‐based stereotactic body radiotherapy (SBRT) for prostate cancer.MethodsFifty‐five patients underwent insertion of a hydrogel spacer and were divided into groups 1 and 2 of the PTV separated from and overlapping with the rectum, respectively. Prescribed doses of 36.25–45 Gy in five fractions were delivered to the PTV. The spacer cover ratio (SCR) and hydrogel–implant quality score (HIQS) were calculated.ResultsDosimetric and quantitative parameters of the hydrogel spacer distribution were compared between the two groups. For PTV, D99% in group 1 (n = 29) was significantly higher than that in group 2 (n = 26), and Dmax, D0.03cc, D1cc, and D10% for the rectum were significantly lower in group 1 than in group 2. The SCR for prostate (89.5 ± 12.2%) in group 1 was significantly higher (p < 0.05) than that in group 2 (74.7 ± 10.3%). In contrast, the HIQS values did not show a significant difference between the groups. An area under the curve of 0.822 (95% confidence interval, 0.708–0.936) for the SCR was obtained with a cutoff of 93.6%, sensitivity of 62.1%, and specificity of 100%.ConclusionsThe SCR seems promising to predict the separation of the rectum from the PTV in linear‐accelerator‐based SBRT for prostate cancer.
The effectiveness of Baduanjin on metabolic syndrome: An overview of systematic reviews and meta‐analyses
Authors: Zhao JingYi , Li Min , Ma KaiLe , Hao Rui , Zhou LiJuan 
Published: February 2024

AbstractObjectiveThis meta‐analysis evaluated the effects of Baduanjin on the metabolic status of individuals with metabolic syndrome (MetS). The aim was to identify effective interventions for MetS prevention and treatment.MethodsWe conducted a comprehensive search of English (PubMed, Embase, Web of Science, and Cochrane Library) and Chinese (CNKI, Wanfang, Chinese Biomedical Database, VIP) databases till August 19, 2022. Randomized controlled trials (RCTs) focusing on Baduanjin for MetS patients were included. Data were pooled and assessed using the Cochrane risk‐of‐bias tool. The Grades of Recommendation, Assessment, Development, and Evaluation for Systematic Reviews was used to evaluate literature quality.ResultsEight RCTs involving 435 participants were included. Baduanjin showed significant improvements in fasting blood glucose (mean difference [MD] = −0.41, 95% confidence interval [CI] [−0.22, −0.61], p < 0.0001) and glycated hemoglobin levels (MD = −0.99, 95% CI [−0.38, −1.60], p < 0.00001). Waist‐to‐hip ratio (MD = −0.04, 95% CI [−0.03, −0.06], p = 0.002), body mass index (MD = −1.60, 95% CI [−0.10, −3.10], p = 0.04), fasting insulin (MD = −4.82, 95% CI [−0.15, −8.59], p = 0.01), systolic blood pressure (MD = −7.16, 95% CI [−5.16, −9.17], p < 0.00001), diastolic blood pressure (MD = −3.43, 95% CI [−0.62, −6.24], p = 0.02), total cholesterol (MD = −0.48, 95% CI [−0.10, −0.85], p = 0.01), triglycerides (MD = −0.39, 95% CI [−0.14, −0.64], p = 0.003), and low‐density lipoprotein cholesterol (MD = −0.52, 95% CI [−0.10, −0.94], p = 0.01) also significantly improved. No adverse events were reported. Literature quality ranged from very low to moderate.ConclusionsBaduanjin effectively improves metabolic status in individuals with MetS, including blood glucose, lipid profile, obesity‐related indicators, insulin levels, and blood pressure. However, the overall literature quality is moderate to low. Further rigorous RCTs are needed to explore Baduanjin's effects on MetS, considering intervention methods, content, and research methodologies.
Bipolar Current Collectors of Cu/polymer/Al Composite for Anode‐Free Batteries
Authors: Liao Xiangbiao , Wang Xiao , Yan Chong , Zhang Baidu , Ni Yong , Yuan Haozhi , Pan Yong , Pan Jun'an , Huang Jiaqi 
Published: February 2024

AbstractThe all‐in‐one design of cathode and anode is a promising strategy to improve energy density and assembly efficiency for lithium batteries. However, it is an important prerequisite to combine negative and positive current collectors in a single sheet. Here, an asymmetric structure of bipolar composite current collector (BCCC), thin copper (Cu) and aluminum (Al) metal layers respectively deposited on each side of a thin polyethylene terephthalate (PET) polymer substrate is developed. Unlike conventional metal foils, the electronically insulative polymer blocks electron transfer between the cathode and anode coated on each side of BCCC. Buckling‐based mechanics measurement and molecular simulation are conducted to quantitatively evaluate the interfacial strength of metal/polymer, which is enhanced by introducing an intermediate chromium (Cr) layer. For applications in anode‐free wound batteries, the integrated sheet of separator/cathode/BCCC can simplify the alignment of the electrodes during the winding process. Without special surface and electrolyte optimizations, a higher Coulombic efficiency (99.1%) and larger capacity retention (50.0%) are achieved after 100 cycles in the LiNi0.8Co0.1Mn0.1O2 anode‐free battery than the battery using Cu foils.
Molecularly Reconfigurable Neuroplasticity of Layered Artificial Synapse Electronics
Authors: Kumbhar Dhananjay D. , Je Yeonjin , Hong Seongin , Lee Donghyun , Kim Hyeongtae , Kwon Mi Ji , Cho Su‐Yeon , Lee Do‐Hyeon , Lim Dong‐Hyeok , Kim Sunkook , Park Jun Hong 
Published: February 2024

AbstractBrain‐inspired electronics with multimodal signal processing have been investigated as the next‐generation semiconductor platforms owing to the limitations of von Neumann architecture, which limits data processing and energy consumption efficiencies. This study demonstrates the molecular reconfiguration of plasticity of artificial synaptic devices with tunable electric conductance based on molecular dynamics at the channel surfaces for realizing chemical multimodality. Carrier transport dynamics are adjusted using the density of trapped carriers for the molecular adsorption of HS in the MoSe2 channel, and the results are consistent with the molecular simulations. In molecular dynamics‐controlled devices, enhanced hysteresis enables the engineering of artificial neuroplasticity, mimicking the neurotransmitter release of biological synapses. Owing to the molecular reconfigurability of MoSe2 devices, the synaptic weights of excitatory and inhibitory synapse modes are significantly enhanced. Thus, this study can potentially contribute to the creation of the next generation of multimodal interfaces and artificial intelligence hardware realization.
Sequentially Deposited Elastomer‐Based Ternary Active Layer for High‐Performance Stretchable Organic Solar Cells
Authors: Tang Weibing , Ding Zicheng , Su Yueling , Weng Qiang , Zhang Yi , Li Ruipeng , Huang Wenliang , Wang Zhichao , Wu Yin , Han Yanchun , Zhao Kui , Yang Zhou , Wang Xiaochen , Liu Shengzhong (Frank) 
Published: February 2024

AbstractStretchable organic solar cells (OSCs) with high power conversion efficiency and good mechanical deformation are promising as power sources for wearable electronics. However, synergistic improvement of both photovoltaic efficiency and mechanical ductility is challenging for state‐of‐the‐art polymer donor: non‐fullerene acceptor (NFA)‐based photovoltaic active layers. Here, a high‐performance stretchable OSC with a power conversion efficiency of 16.54% and a crack‐onset strain of 26.38% by synergetic optimization film microstructure of sequentially deposited ternary active layer consisting of a polymer donor poly[2,6‐(4,8‐bis(5‐(2‐ethylhexyl‐3‐fluoro)thiophen‐2‐yl)‐benzo[1,2‐b:4,5‐b']dithiophene))‐alt‐5,5'‐(5,8‐bis(4‐(2‐butyloctyl)thiophen‐2‐yl)dithieno[3',2':3,4;2'',3'':5,6]benzo[1,2‐c][1,2,5]thiadiazole)] (D18), an NFA 2,2'‐((2Z,2'Z)‐((12,13‐bis(2‐ethylhexyl)‐3,9‐diundecyl‐12,13‐dihydro‐[1,2,5]thiadiazolo[3,4‐e]thieno[2'',3'':4',5']thieno[2',3':4,5]pyrrolo[3,2‐g]thieno[2',3':4,5]thieno[3,2‐b]indole‐2,10‐diyl)bis(methanylylidene)bis(5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐indene‐2,1‐diylidene))dimalonitrile) (Y6), and an elastomer polystyrene‐block‐poly(ethylene‐ran‐butylene)‐block‐polystyrene (SEBS) is reported. Adding a low‐content solvent additive para‐xylene into main solvent carbon disulfide induces high‐density fibers networks with low crystallinity in bottom D18 layer, and this further suppresses the large phase separation between Y6 and SEBS in top layer. Moreover, incorporating a solid additive 1,3‐dibromo‐5‐chlorobenzene with better compatibility with Y6 can promote Y6 dispersions to form smaller ordered domains in SEBS matrix. Finally, the optimal ternary active layer shows significantly higher efficiency and stretchability, resulting in a large efficiency‐stretchability factor of 4.36%, which is among the best values for stretchable OSCs.
Bi‐Directional Growth of Thin Films: Unlocking Anisotropic Ferromagnetism and Superconductivity
Authors: Bonmassar Nicolas , Christiani Georg , Brucker Maximilian , Logvenov Gennady , Suyolcu Y. Eren , van Aken Peter A. 
Published: February 2024

AbstractThe pursuit of breakthroughs in thin film technology drives the exploration of novel growth strategies for quantum materials that surpass conventional limitations. Departing from the prevailing unidirectional growth approach, the methodology allows for atomic precision in both the in‐plane and out‐of‐plane directions. To demonstrate the capabilities of this transformative technique, a bi‐directionally grown superlattice comprised of alternating LaMnO3 and SrMnO3 layers is engineered, enabling the emergence of interfacial ferromagnetism. By adopting this superlattice as a model system, the vast potential of the approach is highlighted through comprehensive analysis and characterization. Furthermore, the application of the method is extended to the growth of superconducting La1.84Sr0.16CuO4 thin films on various offcut substrates. Remarkably, these substrates induce an anisotropic critical current originating from two distinct mechanisms.
Modified Highly Elastic 3D Nanofiber Embolic Scaffolds for Precise In Situ Embolization Therapy
Authors: Cai Pengfei , Cao Lei , Ding Yangfan , Han Yu , Yu Xiao , Cui Jie , Wang Hongsheng , Wu Jinglei , EL‐Newehy Mohamed , Abdulhameed Meera Moydeen , Mo Xiumei , Wang Shoubao , Sun Binbin 
Published: February 2024

AbstractTranscatheter arterial embolization (TAE) is an effective treatment for hemangiomas or highly vascular tumors. However, conventional embolic agents have limitations such as off‐target embolization, regurgitation, and embolic migration, which can affect the efficacy and safety of embolic therapy. The study designed a highly elastic modified embolic scaffold constructed with Polycaprolactone/Gelatin (PCL/GEL) nanofibers to achieve precise in situ embolization in vivo. The embolic scaffolds can be extruded to a small size for smooth intervention in the vessel and rapidly regain their volume when reaching the target area. The results of the in vitro study indicate that the embolic scaffolds modified with lysine and PEI exhibit good biocompatibility and functionality. Furthermore, the in vivo rabbit ear embolization test demonstrated that the modified embolic scaffolds fit closely to the vessels and induced a significant amount of neo tissue deposition in the embolized area. The embolization process using the modified embolic scaffolds is safe and stable and results in more desirable embolization outcomes compared to commercial gelatin embolic agents. In conclusion, the modified highly elastic embolic scaffolds designed in this study offer a novel method for in situ embolization that has potential for clinical application in TAE.
Substituting Poly(ethylene glycol) Lipids with Poly(2‐ethyl‐2‐oxazoline) Lipids Improves Lipid Nanoparticle Repeat Dosing
Authors: Sanchez Alejandro J. Da Silva , Loughrey David , Echeverri Elisa Schrader , Huayamares Sebastian G. , Radmand Afsane , Paunovska Kalina , Hatit Marine , Tiegreen Karen E. , Santangelo Philip J. , Dahlman James E. 
Published: February 2024

AbstractPoly(ethylene glycol) (PEG)–lipids are used in Food‐and‐Drug‐Administration‐approved lipid nanoparticle (LNP)–RNA drugs, which are safe and effective. However, it is reported that PEG–lipids may also contribute to accelerated blood clearance and rare cases of hypersensitivity; this highlights the utility of exploring PEG–lipid alternatives. Here, it is shown that LNPs containing poly(2‐ethyl‐2‐oxazoline) (PEOZ)–lipids can deliver messenger RNA (mRNA) to multiple cell types in mice inside and outside the liver. In addition, it is reported that LNPs formulated with PEOZ–lipids show reduced clearance from the bloodstream and lower levels of antistealth lipid immunoglobulin Ms than LNPs formulated with PEG–lipids. These data justify further exploration of PEOZ–lipids as alternatives to PEG–lipids in LNP–RNA formulations.
Brain‐Decellularized ECM‐Based 3D Myeloid Sarcoma Platform: Mimicking Adaptive Phenotypic Alterations in the Brain
Authors: Yoon Heejeong , Kang Joo H. , Cho Seung Woo , Park Chun Gwon , Kim Dong‐Wook , Park Tae‐Eun 
Published: February 2024

AbstractLeukemia circulates in the bloodstream and induces various symptoms and complications. Occasionally, these cells accumulate in non‐marrow tissues, forming a tumor‐like myeloid sarcoma (MS). When the blast‐stage leukemia cells invade the brain parenchyma, intracranial MS occurs, leading to a challenging prognosis owing to the limited penetration of cytostatic drugs into the brain and the development of drug resistance. The scarcity of tissue samples from MS makes understanding the phenotypic changes occurring in leukemia cells within the brain environment challenging, thereby hindering development of effective treatment strategies for intracranial MS. This study presents a novel 3D in vitro model mimicking intracranial MS, employing a hydrogel scaffold derived from the brain‐decellularized extracellular matrix in which suspended leukemia cells are embedded, simulating the formation of tumor masses in the brain parenchyma. This model reveals marked phenotypic changes in leukemia cells, including altered survival, proliferation, differentiation, and cell cycle regulation. Notably, proportion of dormant leukemia stem cells increases and expression of multidrug resistance genes is upregulated, leading to imatinib resistance, mirroring the pathological features of in vivo MS tissue. Furthermore, suppression of ferroptosis is identified as an important characteristic of intracranial MS, providing valuable insights for the development of targeted therapeutic strategies.
Genetically Engineered Cytomembrane Nanovaccines for Cancer Immunotherapy
Authors: Pan Yuanwei , Wu Xianjia , Liu Lujie , Zhao Chenchen , Zhang Jing , Yang Shengren , Pan Pan , Huang Qinqin , Zhao Xing‐Zhong , Tian Rui , Rao Lang 
Published: February 2024

AbstractCancer nanovaccines have attracted widespread attention by inducing potent cytotoxic T cell responses to improve immune checkpoint blockade (ICB) therapy, while the lack of co‐stimulatory molecules limits their clinical applications. Here, a genetically engineered cancer cytomembrane nanovaccine is reported that simultaneously overexpresses co‐stimulatory molecule CD40L and immune checkpoint inhibitor PD1 to elicit robust antitumor immunity for cancer immunotherapy. The CD40L and tumor antigens inherited from cancer cytomembranes effectively stimulate dendritic cell (DC)‐mediated immune activation of cytotoxic T cells, while the PD1 on cancer cytomembranes significantly blocks PD1/PD‐L1 signaling pathway, synergistically stimulating antitumor immune responses. Benefiting from the targeting ability of cancer cytomembranes, this nanovaccines formula shows an enhanced lymph node trafficking and retention. Compared with original cancer cytomembranes, this genetically engineered nanovaccine induces twofold DC maturation and shows satisfactory precaution efficacy in a breast tumor mouse model. This genetically engineered cytomembrane nanovaccine offers a simple, safe, and robust strategy by incorporating cytomembrane components and co‐stimulatory molecules for enhanced cancer immunotherapy.
HLCT‐Type Acceptor Molecule‐Based Exciplex System for Highly Efficient Solution‐Processable OLEDs with Suppressed Efficiency Roll‐Offs
Authors: Yin Yixiao , Lai Xiaoyi , Ma Qian , Ma Huili , Zhu Weiguo , Lee Jun Yeob , Wang Yafei 
Published: February 2024

AbstractExciplex systems are promising candidates for thermally activated delayed fluorescence (TADF) molecules because of the small energy difference between the lowest singlet and triplet excited states (ΔEST). However, realizing high‐efficiency and low‐external‐quantum‐efficiency (EQE) roll‐off in solution‐processed organic light‐emitting diodes (OLEDs) using an exciplex system remains a formidable challenge. In this study, two (HLCT)‐type isomers with a spiro skeleton, 2‐tBuspoCz‐TRZ and 10‐tBuspoCz‐TRZ, are designed and synthesized as acceptors of exciplexes, where tert‐butylspirofluorene indole is regarded as a donor and the triazine unit as an acceptor. Green exciplex emissions are observed for the 2‐tBuspoCz‐TRZ:TAPC and 10‐tBuspoCz‐TRZ:TAPC exciplexes, indicating distinct TADF characteristics with a very small ΔEST of 35 ± 5 meV. By using the TADF exciplex system based on the HLCT acceptor as an emitter, solution‐processable OLEDs achieve a maximum external quantum efficiency (EQEmax) of 20.8%. Furthermore, a high EQEmax > 25% with a very low‐efficiency roll‐off (≈3.5% at 1000 cd m−2) is obtained for solution‐processable phosphorescent devices using HLCT‐based exciplexes as the host matrix of phosphors. This study paves the way for a novel strategy for designing acceptor exciplex molecules for effective TADF molecules and host matrices in solution‐processable OLEDs.
Enhancement of the Surface and Mechanical Properties of Polyurethane Coating Through Changing the Additive Ratio of Silane
Authors: Kant İrem Elmas , Tarkuç Simge , Köken Nesrin , Yeşilçubuk Süleyman Alper , Kızılcan Nilgün 
Published: February 2024

AbstractContinuous development in the formulation and processing techniques of polyurethane (PU) coatings improves an aesthetic appearance as well as protection against environmental factors. In this study, the formulation of PU coating with polyethylene glycol 600 (PEG600), isophorone diisocyanate (IPDI), and trimethoxysilylpropylcarbamoyloxyhexane (TMSCH) silane‐based additive is optimized to obtain high scratch‐resistant coating. An addition of 43.1 wt.% TMSCH in PU formulation resulted in a significant improvement in the scratch resistance and wettability properties compared with pure PU film. The homogenously prepared micron‐thick coatings are characterized using scanning electron microscopy analysis and Fourier transform infrared spectroscopy. The results confirm the presence of silane additives in the PU coating matrix. The mechanical properties improved due to the increased crosslinking networks via the formation of urethane bonds by increasing the TMSCH in PU formulation. Prepared PU coating showed combined features of transparency, hydrophobicity, scratch resistance, and mechanical strength that make it a promising candidate for household appliances.
High‐Performance Green Quasi‐2D Perovskite Light‐Emitting Diodes via Passivated Defects
Authors: Yang Wei , Ban Xin‐Xin , He Xiao‐Li , Huang Xin‐Mei , Wang Xiao‐Yu , Zhang Yong , Gao Chun‐Hong 
Published: February 2024

AbstractIn next generation semiconductors, metal halide perovskite materials would replace traditional light‐emitting materials since their exceptional photoelectronic characteristics. The future development of perovskite light‐emitting diodes have generated challenges such as abundant surface or interfacial defects and exciton quenching. To overcome these challenges, the light‐emitting layer is modified utilizing benzimidazole/phosphine oxide hybrid 1,3,5‐tris(1‐(4‐(diphenylphenylphosphoryl)phenyl)‐1H‐benzo[d]imidazol‐2‐yl)benzene (TPOB) and 1,3,5‐tris(diphenylphosphoryl)benzene (TPO) with high triple energy state. It is demonstrated by X‐ray photoelectron spectroscopy results that the oxygen atoms in the P = O functional group of TPOB and TPO provided lone electron pairs coordinate to the unsaturated Pb2+ in turn led to a decrease in the electron cloud density of Pb2+ and Br‐, which can suppress defects. Additionally, this technique improved the morphology of film, reduced surface roughness, and facilitated carrier transport, all of which are crucial for achieving high‐emission efficiency. As a result, the optimal devices has EQEs of 16.20 (TPOB) and 20.48% (TPO), respectively. Furthermore, the devices demonstrated excellent reproducibility. Excitingly, the champion EQE value for the optimal device is 22.64%. Simultaneously, it can increase the stability of the devices and the lifetimes are increased from 1231 s (Pristine) to 5421 (TPOB) and 5631 s (TPO).
Anti‐Fouling Polymer or Peptide‐Modified Electrochemical Biosensors for Improved Biosensing in Complex Media
Authors: Saxena Survanshu , Sen Payel , Soleymani Leyla , Hoare Todd 
Published: February 2024

AbstractElectrochemical biosensing represents a highly effective technology for detecting disease biomarkers given its high sensitivity, low and clinically relevant limit of detection, and cost effectiveness. However, in complex media such as urine, blood, sweat or saliva, biosensing performance can be significantly impacted by electrode biofouling by proteins, cells, lipids, and other matrix components. Such biofouling leads to reduced signal from the target analyte coupled with an elevated background signal, resulting in poor signal‐to‐noise ratios (SNRs), reduced sensitivity, and lower specificity. This comprehensive review describes the design of anti‐fouling polymers and peptides as a potential solution to prevent or suppress electrochemical biosensor fouling. Various anti‐fouling polymers and peptides developed for improved biosensing in complex media are summarized in the context of their mechanism(s) of anti‐fouling, methods of deposition, and practical applications. Recent advances and persistent challenges in the field are also reviewed to provide perspectives on new directions toward enhancing anti‐fouling in electrochemical biosensors.