bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Synthesis of Copper Nanoparticles Using Sargassum spp. for Electrochemical Reduction of CO2
Authors: Figueroa Ramírez Sandra Jazmín , Escobar Morales Beatriz , Pantoja Velueta Diego Alonso , Sierra Grajeda Juan Manuel T. , Alonso Lemus Ivonne Liliana , Aguilar Ucán Claudia Alejandra 
Published: January 2024

AbstractThis study presents a green method of producing copper nanoparticles (CuNPs) using aqueous extracts from Sargassum spp. as reducing, stabilizing, and capping agents. The CuNPs created using this algae‐based method are not hazardous, they are eco‐friendly, and less toxic than their chemically synthesized counterparts. The XRD characterization of the CuNPs revealed the presence of Cu and CuO, with a crystallite size ranging from 13 to 17 nm. Following this, the CuNPs were supported onto a carbon substrate, also derived from Sargassum spp. (biochar CSKPH). The CuNPs in biochar (CuNPs‐CSKPH) did not appear in the XRD diffractograms, but the SEM‐EDS results showed that they accounted for 36 % of the copper weight. The voltamperometric study of CuNps‐CSKPH in acid media validated the presence of Cu and the amount was determined to be 2.58 μg. The catalytic activity of CuNPs‐CSKPH was analyzed for the electrochemical reduction of CO2. The use of Sargassum spp. has great potential to tackle two environmental problems simultaneously, by using it as raw material for the synthesis of activated biochar as support, as well as the synthesis of CuNPs, and secondly, by using it as a sustainable material for the electrochemical conversion of CO2.
Analysis of Photocatalytic Degradation of Phenol by Zinc Oxide Using Response Surface Methodology
Authors: Seloglu Meliha , Orhan Ramazan , Selen Veyis , Dursun Gülbeyi 
Published: January 2024

AbstractIn this study, the photocatalytic degradation of phenol, which is commonly found in industrial wastewater at high rates, was investigated using a zinc oxide (ZnO) catalyst. It is thought that our findings will contribute to the removal of phenol in industrial wastewater. The experimental study was conducted in a batch‐type air‐fed cylindrical photocatalytic reactor, and a central composite design (CCD) was chosen and analyzed using response surface methodology (RSM). The study aimed to explore the effects of initial phenol concentration, catalyst concentration, airflow rate, and degradation time on the photocatalytic degradation of phenol and the removal efficiency of total organic carbon (TOC). A quadratic regression model was developed to establish the relationship between phenol degradation, TOC removal effectiveness, and the four factors mentioned. The validity of the model was assessed through an analysis of variance (ANOVA). A good agreement was observed between the model results and the experimental data. As a result of the experiments carried out under optimized conditions, the degradation percentage of phenol was found to be 77.15 %, and the degradation percentage of TOC was 59.87 %. Additionally, pseudo‐first‐order kinetics were used in the photocatalytic degradation of phenol.
Scale‐up fabrication and advanced properties of recycled polyethylene terephthalate aerogels from plastic waste
Authors: Goh Xue Yang , Deng Xinying , Teo Wern Sze , Ong Ren Hong , Nguyen Luon Tan , Bai Tianliang , Duong Hai M. 
Published: January 2024

AbstractTraditional fabrication methods of aerogels are time consuming, toxic, and difficult to implement, making the production of aerogels expensive and severely limits widespread adoption. Nonwoven technology is introduced to prepare fibers that can be used to create polymer‐based aerogel. With its introduction, it allows the continuous flow of fine fibers and eliminates the bottlenecking fiber preparation phase of the fabrication process. Using recycled polyethylene terephthalate (rPET) fibers and polyvinyl alcohol, two types of rPET aerogels are successfully fabricated, namely the lab‐scale and the large‐scale aerogels, to investigate the effectiveness of the nonwoven process line for the fiber preparation processing step. Fibers prepared manually (lab‐scale aerogels) and with the aid of a fiber preparation production line (large‐scale aerogels) are characterized and compared. Both lab‐scale and large‐scale aerogels exhibited the required specifications of low densities (12.6–45.9 and 13.2–43.7 mg/cm3, respectively) and high porosity (99.1%–96.7% and 99.0%–96.8%, respectively). Their thermal conductivity (23.4–34.0 and 23.2–31.9 mW/m⋅K, respectively) and compressive modulus (4.74–21.91 and 4.53–22.29 kPa, respectively) were also relatively similar. The advantage of scaled preparation of fibers for aerogel manufacturing includes higher throughputs (the line can produce up to 60 kg/h), improved consistency for defibrillation, homogenous fiber blending, and accurate replication of laboratory‐made aerogel properties. This demonstrates the viability of using nonwoven technology to scale for continuous production to bring down the production cost.Highlights
Scale up production of aerogels using nonwoven technology
Improving preparation process of aerogels through homogenous fiber blending
Preparation rate of up to 60 kg/h
Developed high porosity aerogels up to 99%
Good thermal insulation of 23.2–31.9 mW/m⋅K
Registration of Arkot 1102ne cotton germplasm line
Authors: Bourland Fred M. , Jones Don C. 
Published: January 2024

AbstractArkot 1102ne (Reg. no. GP‐1142; PI 702558) is a conventional, nectariless cotton (Gossypium hirsutum L.) germplasm line released by the Arkansas Agricultural Experiment Station in October 2022. The germplasm line represents an ongoing effort to develop improved genotypes with enhanced yield, yield components, seed traits, earliness, host plant resistance, and fiber properties. Arkot 1102ne was compared to ‘UA48’ and ‘UA222’ over 5 years and four test sites in Arkansas. Across all the test sites, lint yields of Arkot 1102ne were 7.9% and 20.8% higher than those of UA222 and UA48, respectively, due to its higher lint percentage, seed per area, and fiber density. Arkot 1102ne produced the highest average yield of 21 genotypes over 10 locations in the 2019 Regional Breeders’ Network Test (RBTN). Arkot 1102ne produced the highest oil and protein percentages at four 2019 RBTN locations where seed were evaluated. Host plant resistance traits that have been measured on Arkot 1102ne include bacterial blight resistance and Verticillium wilt tolerance. Leaf pubescence and bract trichome density of Arkot 1102ne were intermediate between UA48 and UA222, but stem pubescence was lower. This combination of host plant resistance and yield components should lead to more stable yield production over contrasting environments. The fiber quality of Arkot 1102ne was lower than UA48 and was similar to that of UA222.
Effects of genetic variation on the structure of RNA and protein
Authors: Kang Jingxuan , Wei Siyu , Jia Zhe , Ma Yingnan , Chen Haiyan , Sun Chen , Xu Jing , Tao Junxian , Dong Yu , Lv Wenhua , Tian Hongsheng , Guo Xuying , Bi Shuo , Zhang Chen , Jiang Yongshuai , Lv Hongchao , Zhang Mingming 
Published: January 2024

AbstractChanges in the structure of RNA and protein, have an important impact on biological functions and are even important determinants of disease pathogenesis and treatment. Some genetic variations, including copy number variation, single nucleotide variation, and so on, can lead to changes in biological function and increased susceptibility to certain diseases by changing the structure of RNA or protein. With the development of structural biology and sequencing technology, a large amount of RNA and protein structure data and genetic variation data resources has emerged to be used to explain biological processes. Here, we reviewed the effects of genetic variation on the structure of RNAs and proteins, and investigated their impact on several diseases. An online resource (http://www.onethird‐lab.com/gems/) to support convenient retrieval of common tools is also built. Finally, the challenges and future development of the effects of genetic variation on RNA and protein were discussed.
Rhamnolipids‐based glycosylated coating for preparing non‐charging polymeric materials surfaces
Authors: Fang Yan , Wang Jie , Gonuguntla Spandhana , Jiang Lei , Ye Xiangyu 
Published: January 2024

AbstractPolymer materials are typical insulators that are easily charged by contact electrification. Static charge generated by contact electrification on their surfaces can lead to lots of undesirable consequences, including a reduction in efficiency of manufacturing processes, damage to equipment, and even explosions. Thus, it is important to develop effective strategies to prevent the generation of static charge when surfaces of polymer materials come into contact. Here, we coated polymer materials with rhamnolipids (RLs) to create non‐charging surfaces. This innovative technique, based on glycosylated coatings using RLs, offers a universal solution that can be easily applied to a wide range of polymeric materials conferring resistance to surface charging via contact electrification. The amount of static charges generated was found to reduce dramatically in both low (~15%) and high (~60%) humidity situations. The reduction of charge is due to either or both of the following two mechanisms: by increasing surface conductivity driven by the hydrophilic groups of the RLs molecules, and or by their radical‐scavenging properties. Predictably, this new effective strategy is ideal for producing antistatic dipping and spray solution for various practical applications.
Identification of novel biomarkers for frailty diagnosis via serum amino acids metabolomic analysis using UPLC‐MS/MS
Authors: Zhou Mengyuan , Sun Wenjing , Chu Jiaojiao , Liao Yingping , Xu Pengfei , Chen Xujiao , Li Meng 
Published: January 2024

AbstractPurposeThis study was aimed to analyze serum amino acid metabolite profiles in frailty patients, gain a better understanding of the metabolic mechanisms in frailty, and assess the diagnostic value of metabolomics‐based biomarkers of frailty.Experimental DesignThis study utilized the ultra‐performance liquid chromatography tandem mass spectrometry to examine amino acids associated with frailty. Additionally, we employed multivariate statistical methods, metabolomic data analysis, receiver operating characteristic (ROC) curve analysis, and pathway enrichment analysis.ResultsAmong the assayed amino acid metabolites, we identified biomarkers for frailty. ROC curve analysis for frailty diagnosis based on the modified Fried's frailty index showed that the areas under ROC curve of tryptophan, phenylalanine, aspartic acid, and combination were 0.775, 0.679, 0.667, and 0.807, respectively. ROC curve analysis for frailty diagnosis based on Frail Scale showed that the areas under ROC curve of cystine, phenylalanine, and combination of amino acids (cystine, L‐Glutamine, citrulline, tyrosine, kynurenine, phenylalanine, glutamin acid) were 0.834, 0.708, and 0.854 respectively.Conclusion and Clinical RelevanceIn this study, we explored the serum amino acid metabolite profiles in frailty patients. These present metabolic analyses may provide valuable information on the potential biomarkers and the possible pathogenic mechanisms of frailty.Clinical SignificanceFrailty is a clinical syndrome, as a consequence it is challenging to identify at early course of the disease, even based on the existing frailty scales. Early diagnosis and appropriate patient management are the key to improve the survival and limit disabilities in frailty patients. Proven by the extensive laboratory and clinical studies on frailty, comprehensive analysis of metabolic levels in frail patients, identification of biomarkers and study of pathogenic pathways of metabolites contribute to the prediction and early diagnosis of frailty. In this study, we explored the serum amino acid metabolite profiles in frailty patients. These present metabolic analyses may provide valuable information on the potential biomarkers and the possible pathogenic mechanisms of frailty.
Pulmonary hypertension in the setting of interstitial lung disease: Approach to management and treatment. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative—Group 3 Pulmonary Hypertension
Authors: Shlobin Oksana A. , Shen Eric , Wort Stephen J. , Piccari Lucilla , Scandurra John A. , Hassoun Paul M. , Nikkho Sylvia M. , Nathan Steven D. 
Published: January 2024

AbstractPulmonary hypertension (PH) due to interstitial lung disease (ILD), a commonly encountered complication of fibrotic ILDs, is associated with significant morbidity and mortality. Until recently, the studies of pulmonary vasodilator therapy in PH‐ILD have been largely disappointing, with some even demonstrating the potential for harm. This paper is part of a series of Consensus Statements from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative for Group 3 Pulmonary Hypertension, with prior publications covering pathogenesis, prevalence, clinical features, phenotyping, clinical trials, and impact of PH‐ILD. It offers a comprehensive review of and a holistic approach to treatment of PH‐ILD, including the management of underlying interstitial lung diseases, importance of treating the comorbidities, emphasis on importance of exercise and palliation of dyspnea, and review of the most up‐to‐date guidelines for referral for potential lung transplant work up. It also summarizes the prior, ongoing, and possibly future studies in treatment of the vascular derangement of this morbid condition.
Finite‐time adaptive stabilization and H∞$$ {H}_{\infty } $$ control for a class of nonlinear Hamiltonian singular systems with parametric perturbations
Authors: Jin Qiang , Sun Liying , Yang Renming 
Published: January 2024

AbstractThis article addresses the finite‐time adaptive stabilization and finite‐time adaptive control problems of a class of nonlinear Hamiltonian singular systems with parametric perturbations. Under the suitable state feedback control scheme, a dissipative differential‐algebraic form of the nonlinear Hamiltonian singular system is obtained. According to this dissipative form, the finite‐time adaptive stabilization of the nonlinear Hamiltonian singular system with unknown parametric perturbations is investigated using the Hamiltonian function method. Then, considering the system with the external disturbances, a finite‐time adaptive controller is designed. Finally, the simulation results of the nonlinear singular circuit system demonstrate the efficacy of the controller designed in this article.
Molecular Insight into the Ternary Complex Formation between Ethambutol, Isoniazid and β‐Cyclodextrin
Authors: Goh Soen Qeng , Adnan Rohana , Jumbri Khairulazhar , Ishak Mohd Adil Iman , Abdullah Nor Ain Fathihah , Rahim Nurul Yani 
Published: January 2024

AbstractLong term intake of antituberculosis drugs will lead to severe adverse reactions that will ultimately deteriorate a patient's health and well‐being. With that, the ternary inclusion complex was explored, whereby β‐cyclodextrin (β‐CD) was chosen as the supramolecular host carrier to accommodate two kinds of first line antituberculosis guest drug molecules simultaneously, namely isoniazid (INH) and ethambutol (ETB) which would provide many therapeutic benefits. The inclusion complex of β‐CD/INH/ETB was prepared using solvent evaporation method. Fourier transform infrared spectroscopy (FT‐IR), proton nuclear magnetic resonance spectroscopy (1H‐NMR), and 2‐dimensional nuclear Overhauser effect spectroscopy (2D‐NOESY) NMR were used to investigate the functional groups and structure of the complex. Scanning electron microscopy (SEM) and X‐ray diffraction (XRD) were employed to study the surface morphology and crystallinity changes during complex formation. Thermogravimetric analysis (TGA) was performed to investigate the thermal properties of the complex. FT‐IR and both types of NMR results had revealed the successful penetration of both the drug molecules into the β‐CD cavity. SEM images and XRD spectra had shown a drastic change in surface structure and reduction in crystallinity during complex formation, which had indicated successful formation of a new compound. TGA had proven that the complex had significantly greater thermal stability as compared to the pure components. Molecular dynamics (MD) and molecular docking simulations were also performed to understand the molecular interaction between β‐CD, INH, and ETB. Through precise calculations of interaction and binding energies, β‐CD/INH/ETB was found to be a more stable inclusion complex compared to the binary β‐CD/INH and β‐CD/ETB complexes.
Diclofenac Sodium‐Encapsulated Poly(lactic‐co‐glycolic acid) Nanoparticles: A Non‐antibiotic Formulation to Attenuate the Proteolytic Activity of P. aeruginosa Clinical Isolates
Authors: Esnaashari Fatemeh , Rostamnejad Dorna , Zahmatkesh Hossein , Asadi Rahmani Fatemeh , Zamani Hojjatolah , Rasti Behnam 
Published: January 2024

AbstractEncapsulating drugs in poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles can provide a gradual and consistent drug release. Herein, diclofenac sodium‐encapsulated PLGA nanoparticles (DS‐PLGA NPs) were synthesized, characterized, and their effects on bacterial proteolysis and elastolytic activity were evaluated using skim milk agar plate, elastin‐congo red, and staphylolysin disk susceptibility assays. Quantitative PCR was employed to examine the effect of nanoparticles on the expression of lasA/B genes. The DS‐PLGA NPs displayed spherical morphology with an average size of 86 nm, zeta potential of ‐15.2 mV, and DLS size of 124.6 nm. At a sub‐inhibitory concentration, DS‐PLGA NPs inhibited bacterial elastolytic activity by 41.6 to 62.1% during 30–180 min of incubation. The elastolytic curve slopes of samples from PLGA and DS‐PLGA treated groups were respectively 0.0714 and 0.0380 activity/min, indicating a significant reduction of bacterial extracellular elastases by DS‐PLGA NPs. Exposure of bacteria to a sub‐inhibitory concentration of the nanoparticles attenuated the expression of the lasA and lasB genes by 0.21 and 0.31 folds, respectively. Attenuation of the proteolytic activity of P. aeruginosa suggests that the antivirulence potential of the DS‐PLGA NPs along with the anti‐inflammatory properties of diclofenac sodium, can be considered for the treatment of acute and chronic P. aeruginosa infections.
Co‐encapsulation of Curcumin and Paclitaxel using Non‐ionic Surfactant Based Nanovesicles Suppresses Growth of Ovarian Carcinoma through the Inhibition of Nuclear Factor κB and AKT1
Authors: Haghi Karamallah Mojtaba , Alemi Ashraf , Ahmad Hosseini Seyed , Tahery Noorollah , Radmanesh Esmat , Malihi Reza , Zare‐Zardini Hadi , Farrokhifar Majid , Farokhifar Mohammad , Haghi Karamallah Somayeh 
Published: January 2024

AbstractCurcumin (Cur) indicates P‐glycoprotein inhibitory activity by downregulating the nuclear factor (NF)‐κB signaling and the PI3K/AKT/mTOR pathway. Curcumin has limited due to its low water‐solubility. Therefore, using novel chemotherapeutic nanoformulations of curcumin or combining it with paclitaxel (PCL) may be more effective against cancer. Recently, we demonstrated that the combination of chemotherapy with PCL and Cur, using non‐ionic surfactant‐based nano‐vesicles (NISV), exhibited enhanced synergistic anticancer efficacy in breast cancer cells. However, the effect of combining these drugs using non‐ionic surfactant‐based nano‐vesicles for treating ovarian cancer, particularly in terms of their influence on AKT1 and NF‐kappa B, has not been investigated. Hereupon, we decided to investigate the single and combination treatment with Cur and PCL on cell apoptosis, expression of the AKT‐1 gene, and determination of p65‐NF‐κB in OVCAR‐3 cell. The combination of chemotherapy with curcumin and paclitaxel, using NISV, resulted in a higher rate of apoptosis, more efficient reduction in AKT‐1 gene expression (91.2 % reduction in PCL‐NISV+Cur‐NISV vs. 72.89 % reduction in PCL+Cur free solution), and 79.42 % reduction in NF‐κB activity compared to individual treatments. The findings indicate that combining curcumin and paclitaxel using non‐ionic surfactant‐based nano‐vesicles may be a promising strategy for reducing ovarian cancer growth.
Complex Metal Oxides as Emerging Inorganic Hole‐Transporting Materials for Perovskite Solar Cells
Authors: Bai Yu , He Jingsheng , Ran Ran , Zhou Wei , Wang Wei , Shao Zongping 
Published: January 2024

AbstractPerovskite solar cells (PSCs) have achieved revolutionary progress during the past decades with a rapidly boosting rate in power conversion efficiencies from 3.8% to 26.1%. However, high‐efficiency PSCs with organic hole‐transporting materials (HTMs) suffer from inferior long‐term stability and high costs. The replacement of organic HTMs with inorganic counterparts such as metal oxides can solve the above‐mentioned problems to realize highly robust and cost‐effective PSCs. Nevertheless, the widely used simple metal oxide‐based HTMs are limited by the low conductivity and poor light transmittance due to the fixed atomic environment. As an emerging family of inorganic HTMs, complex metal oxides with superior structural/compositional flexibility have attracted rapidly increasing interest recently, showing superior carrier conductivity/mobility and superb light transmittance. Herein, the recent advancements in the design and development of complex metal oxide‐based HTMs for high‐performance PSCs are summarized by emphasizing the superiority of complex metal oxides as HTMs over simple metal oxide‐based counterparts. Consequently, several distinct strategies for the design of complex metal oxide‐based HTMs are proposed. Last, the future directions and remaining challenges of inorganic complex metal oxide‐based HTMs for PSCs are also presented. This review aims to provide valuable guidelines for the further advancements of robust, high‐efficiency, and low‐cost PSCs.
Physically secure and privacy‐preserving blockchain enabled authentication scheme for internet of drones
Authors: Subramani Jegadeesan , Maria Azees , Rajasekaran Arun Sekar , Lloret Jaime 
Published: January 2024

AbstractThe wide applications of the Internet of Drones (IoD), ranging from package delivery to surveillance, attract the attention of industrialists and academicians. Drones are given the task of obtaining sensitive field information within the flying zone in real‐time. Hence, it is important to tackle the privacy and security issues associated with drones that are employed in these kinds of situations. Also, when the drones move to the new unmanned aerial vehicle (UAV) operator coverage area, the drones are required to execute the authentication process again, which affects the performance of IoD. To overcome the above‐said shortcomings, a physically secure and privacy‐preserving blockchain enabled authentication method is proposed in this paper. The blockchain network permits drones to perform quick re‐authentication by transferring drone authentication codes to the following UAV operators. In the proposed work, the drone does not need to store the secret keys to perform anonymous authentication, and it provides physical security for the drones. When compared to competing techniques, the proposed scheme delivers the needed security features while incurring lower storage, computational, and communication costs.