bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetrapleura tetraptera Fruit Extracts Ameliorate Pentylenetetrazol-Induced Seizures as well as Ensuing Cognitive Deficit and Oxidative Stress
Authors: Ekong Moses Bassey , Bassey Okokon O. , Pessu Nelly A. , Kpobari Godslove V. , Okuku Ekereobong I. , Bassey Rosemary B. , Johnson Ekemini I. , Peter Aniekan I. , Okokon Jude E. , Akpanabiatu Monday I. 
Published: January 2024

Abstract

Kindling is an experimental-induced seizure consistent with epilepsy disease, a chronic neurological disorder characterised by spontaneous and repeated seizures. This disease is associated with oxidative stress, and most therapeutic strategies against epilepsy aim at improving the antioxidant defence mechanism in the brain. However, prolonged usage and associated adverse side effects limit antiepileptics, warranting natural antioxidant patronage. The present study investigated the behavioural and antioxidant actions of Tetrapleura tetraptera fruit extracts (TT) against pentylenetetrazol (PTZ)-kindling rats. Twenty-five male Wistar rats (150–180 g) were assigned into five groups (1–5, n = 5): Control (normal saline, 5 ml/kg body weight, b.w.), PTZ-only (40 mg/kg/b.w. i.p.), and groups 3–5 administered PTZ (40 mg/kg/b.w. i.p.) after, respectively, receiving oral TT (500 mg/kg/b.w.), TT flavonoid (fTT, 50 mg/kg/b.w.), and sodium valproate (SV, 15 mg/kg/b.w.). All administrations were carried out 48 hourly for 21 days. In the end, buried food, novel object recognition (NOR), Y-maze, elevated plus maze (EPM), and beam walk tests were done, and the rats were sacrificed. Whole brains were processed for antioxidant assays. The results showed a high (p < 0.05) seizure score and buried food test latency, preference for the familiar object in the NOR test, aversion to open-arm and reduced grooming in the EPM, reduced beam walk latency, elevated brain malondialdehyde (MDA), and decreased superoxide dismutase (SOD) in the PTZ group. The TT, fTT, and SV suppressed seizure, decreased buried food latency, `preference for the novel object and open-arm, increased grooming, decreased brain MDA, and elevated SOD. In conclusion, TT extracts protected against PTZ-induced cognitive deficits and brain oxidative stress, with results similar to those of the standard anticonvulsant drug, SV.
YWHAG acts as a prognostic marker and is correlated with immune infiltration and cell metastasis in pancreatic cancer
Authors: Wang Daijun , Gu Yanmei , Wang Tongxin , Wang Wenxuan , Wu Songling , He Wenting , Zhao Yang , Li Yumin 
Published: January 2024

Abstract
Pancreatic cancer (PC) is a fetal disease, which is characterized by early metastasis and immune evasion of tumor microenvironment (TME). The current study was designed to identify the potential biomarkers related to metastasis and CD8 + T infiltration in PC. Weighted Gene Co-expression Network Analysis (WGCNA) and protein interaction network were utilized in conjunction with DEGs of PC sourced from TCGA and GEO databases to identify hub genes. The role of YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma) in immune infiltration and cancer metastasis was verified using single-cell sequencing data (GSE154778) of PC. We elucidated the biological effect of YWHAG on PC cells by conducting functional assays. The grey module of WGCNA was presented to be a hub signature. The high level of YWHAG in metastatic cancers was associated with a high degree of T cell infiltration compared with primary tumors. YWHAG was confirmed to be an independent predictor for prognosis. Furthermore, YWHAG silence suppressed cell malignant behavior. When co-cultured with T cells, YWHAG knockdown resulted in an increase in the secretion of TNF-α and a decrease in the secretion of IL-10. Enrichment analysis indicated that YWHAG was involved in focal adhesion and Wnt signaling pathway, which were confirmed by western blotting. In this study, we explored biomarkers associated with metastasis and immune escape, and YWHAG was identified as a key regulator for PC. YWHAG facilitated malignant progression in PC and might be a promising target for immunotherapy by affecting CD8 + T cells infiltration.
Experimental investigation of crest-to-crest wave spring and new lattice structure with enhanced load bearing capacity
Authors: Kumar Ravi Ranjan 
Published: January 2024

Abstract

Instead of foam, 3D printed lattice structure gives full design freedom to achieve the required mechanical property. The wave springs are like a lattice structure which has enhanced characteristics like load bearing capacity, stiffness and energy absorption, energy release characteristics etc. Wave spring may be helpful in the application of smooth landing of drones, robotic structures, vibration isolators. Using the Additive manufacturing, the overlapped lattice structures, without overlapped lattice structures and the overlapped wave spring are fabricated. For the lattice structure, calculation of the energy absorption characteristics is key to evaluate the result of different lattice structures. The present work is focused on the Load bearing capacity, stiffness and energy loss in percentage of the overlapped wave spring and the energy absorbed characteristics of overlapped and without overlapped lattice structure. The load bearing capacity of overlapped wave spring and compressive properties of different lattice structures are obtained through universal testing machine. The result shows that the load bearing capacity of overlapped crest-to-crest wave spring for the 1st Cycle is 386.237N. Comparing the lattice structure, the overlapped crest-to-crest wave spring 10 which has the highest plateau stress value of 3.545MPa is due to overlapped structure and pin arrangement over the circumferential surface. At end, the optimum lattice structure for energy absorption applications is identified.
A Dark Energy Paradigm: III. Unified Dark Sector to Predict Dark Energy, Dark Matter, and Baryonic Matter Distributions
Authors: Moon Yong-Jae , Koh Wook 
Published: January 2024

Abstract
A dark energy paradigm was first developed by authors to solve the cosmological constant problem and to predict lepton masses as evidence. It was used to reveal an underlying structure of a M ON D algorithm to model cold dark matter and to predict galactic dynamics. In this paper, the dark energy paradigm a unified dark sector that is based on Planck’s dimensional analysis, ΛCDM , energy conservation, and force equilibrium is further developed to predict the distribution of dark energy, dark matter, and baryonic matter as well. We find that the dark energy distribution is predicted to be ΩΛ ≈ 0.667, which agrees withthe observed value with a 1% difference. We find that dark matter and baryonic matter distributions are predicted to be Ωc ≈ 0.283 and Ωb ≈ 0.050, respectively, which agree with the observed values with 1% differences.
Natural Radionuclides on Surface Sediment Gosong Beach on the West Coast of Kalimantan Island and Associated Radiation Indices
Authors: Makmur Murdahayu , Untara Untara , Prihatiningsih Wahyu Retno , Yahya Mohamad Nur , Putra Deddy Irawan Permana , Priasetyono Yogi , Jayuska Afghani , Yusuf Saeful , Sihombing Angelina Br 
Published: January 2024

Abstract
Following up with radiological parameter analysis, gamma spectrometry was used to assess the specific activity of 238U, 232Th, and 40K in sediment samples collected at Gosong Beach, on the west coast of Kalimantan Island, Indonesia. Except for 40K, the mean activity levels of 238U, 232Th, and 40K were within the range of the global average. However, the radiological effects of radionuclides at Gosong Beach were found to be safe and no health hazards for the population of Gosong Beach, except for the annual gonadal dose equivalence, which was found to be slightly higher than the global average.
Energy transition in sustainable transport: concepts, policies, and methodologies
Authors: Collazos Julieth Stefany García , Ardila Laura Milena Cardenas , Cardona Carlos Jaime Franco 
Published: January 2024

Abstract

The growth in population, economic expansion, and the dynamism of cities have collectively driven a noticeable surge in the use of public and private transport, resulting in a significant increase in energy consumption within this sector. Consequently, the transport industry now requires an energy transition to meet mobility demands, promote economic growth, and achieve emissions reduction. This article identifies key concepts, policies, and methodologies used in the literature to study the energy transition in the transport sector through a systematic literature review. Our review methodology consisted of two parts: data collection and subsequent analysis aimed at exploring the concepts, methodologies, and policies applied within the context of the energy transition, while considering the mode of transport and geographical scope. The primary findings reveal that electricity is the predominant energy source in this transition, although its prevalence may vary depending on the mode of transport. Biofuels offer a close alternative; however, they primarily contribute to emissions reduction related to fossil fuel use. Natural gas provides an affordable alternative in heavy transport, and hydrogen represents another option, albeit with the potential expense of developing recharging infrastructure. Determinants of this transition include recharging infrastructure, both tax and non-tax incentives, public policies, the generation of electric power using renewable energies, and the proper management of battery life cycles, from mineral extraction to final disposal.
Analysis of spatial and temporal pattern changes and spatial spillover effects of regional agricultural carbon emission efficiency-Taking the Yangtze River Economic Belt as an example
Authors: Wang Mengyao , Jiang Qingrong , Xue Tingdan , Xiao Yaodong , Shan Tengyu , Liu Zihan , Li Hao , Hu Chun 
Published: January 2024

Abstract
Studying the temporal and spatial features and ramifications of regional agricultural carbon emission efficiency (ACEE) under a "double carbon" target is very important. This study examined the ACEE of the Yangtze River Economic Belt (YEB) from 2001 to 2021 using a Super-efficiency model. Kernel density estimation and Moran's I index were used to analyze the ACEE value from time and space perspectives. A spatial Durbin model was trained to empirically investigate the driving forces and geographic spillover effects of ACEE. From a time perspective, the ACEE of YEB shows a fluctuating upward trend. The ACEE values of Jiangsu Province, Zhejiang Province, and Shanghai City were noticeably higher than the mean value of YEB. From the space perspective, the ACEE value is downstream > midstream > upstream, and the overall spatial distribution pattern of “east high and west low” is presented. The results of the spatial Durbin model show that the ACEE of YEB has a substantial positive knock-on impact. Elements like the mechanization level and agricultural industrial structure have a positive driving effect on the YEB ACEE, while pesticides have an inhibitory effect. These results indicated that giving advanced regions their due as radiation-leading regions, strengthening information communication between regions, and encouraging the overall coordinated development of the YEB ACEE are worthwhile recommendations for future improvements.
Study on preparation and CO2 sequestration mechanism of high-strength carbonated Ladle refining slag binder
Authors: Chen Ping , Lin ShenQiu , Xiang WeiHeng , Hu Cheng , Li FangBin , Ding Yu 
Published: January 2024

Abstract

Ladle refining slag (LFS), classified as solid waste, presents an imminent need for comprehensive utilization. Notably, LFS contains a substantial amount of γ-Ca2SiO4 (γ-C2S) with remarkable carbonation potential, making it an ideal candidate for the production of carbonated cement through Carbon Capture and Storage (CCS) technology. This study delves into the carbonation reaction of the cast and molded lump LFS within a CO2 pressure vessel. It systematically examines the influence of water-solid ratio and water content on the initial properties of specimens. Furthermore, the investigation encompasses the impact of temperature, reaction time, and CO2 pressure on carbonation processes and resultant products, contributing to the formulation of a carbonation reaction and mass-transfer mechanism. The research reveals pivotal findings: lower water-solid ratios lead to denser specimens with higher strength, and an optimal 7% water content facilitates effective cementation and reactant dissolution. The controlled growth of densely layered calcite at 20°C yields impressive strengths of up to 120.5MPa, while elevated temperatures, such as 60°C, encourage the growth of smaller calcium carbonate crystals, resulting in a favorable carbon sequestration rate of 19.72%. Extending the carbonation time enhances the conversion rate of γ-C2S to calcium carbonate. Intriguingly, CO2 pressure exerts minimal influence on the specimens. The research elucidates the five-step carbonation process and its underlying diffusion mechanism. In essence, this study harnesses CCS technology to offer a high-value solution for addressing LFS disposal challenges.
Digitalization in Prefabricated Constructions and Reducing Carbon Emission: Empirical Evidence from China
Authors: Mao Qiuyu 
Published: January 2024

Abstract

This study employs the implementation of digitalization in prefabricated constructions (DPC) as an exogenous shock, utilizes provincial panel data from China spanning 1997 to 2019, and uses the difference-in-differences model to identify the causal effect of DPC on carbon emissions in the construction industry (CECI). This study shows that DPC effectively reduces CECI with the results withstanding rigorous testing, including parallel trend tests, placebo tests, and a heterogeneous time-varying treatment test based on Bacon decomposition and the DIDm approach. The mechanism test confirms that DPC reduces CECI through two channels, which are improving existing building technologies and promoting better management capabilities. At the same time, further analyses show that the carbon emissions reduction effect of DPC is more pronounced in regions with a higher degree of marketization, financially developed regions, and regions with abundant human capital. This study contributes to understanding the underlying mechanisms between DPC and CECI, providing new insights for the deeper integration of digital technologies and the construction industry. It offers new avenues for revitalizing the construction sector and facilitating achieving global carbon emissions reduction goals.
How Does Parental Involvement Affect Students' Academic Performance in Public Schools? A Case Study
Authors: Poudel Padam , Subedi Dhanapati 
Published: January 2024

Abstract
Parental involvement is essential in today's modern educational system because it improves school administration and student achievement. The study aimed to explain the value of parents helping their kids become good students who are accepted and motivated to learn for better. A single case study conducted by using qualitative research methodology was carried out in order to explore a) how does parental involvement affect students’ academic performance in public schools? This study included in-depth interviews, document reviews, and observation of the one sampled school and four selected participants. In order to improve children's overall academic attainment in public schools, this study examines relevant policies and pinpoints parental involvement methods. The social theories are used to better understand and discuss parental involvement in school setting. This study reveals that parental involvement is necessary for children’s learning and improve academic performance in public schools. The involvement of parents can be enhanced through a) giving more value to children education, b) enhancing parents-teachers’ relation and interactions, c) fostering home involvement in the holistic educational process, and d) strengthening school’s good governance and management. We conclude that there is a need to investigate a broad framework for parental involvement that includes decentralized administration and flexibility for creativity. Additionally, networking between parents, teachers, and schools is essential. In order to improve the learning environment and guarantee academic brilliance in public schools, it is necessary to examine how to foster parental involvement and develop networks among parents.
Pediatric acute hospitalization for Anorexia Nervosa: an economic evaluation
Authors: Marchili MariaRosaria , Bozzola Elena , Guolo Stefano , Marchesani Silvio , Spina Giulia , Mascolo Cristina , Vicari Stefano , De Jacobis Isabella Tarissi , Raponi Massimiliano , Villani Alberto 
Published: January 2024

Abstract
Background: anorexia nervosa (AN) is a psychiatric disorders which may potentially led to a high risk of health medical complications, suicide and self-harming behaviour. Since Covid-19 pandemic onset in March 2020, evidence suggested an increase occurrence of AN. The main aim of the retrospective analysis is to define the cost of hospitalization in the acute phase (HAP) at IRCCS Bambino Gesù Children Hospital, Rome, Italy, over 2 years study. Secondary purposes are defining the main risk factors for a prolonged hospitalization (including age, sex and comorbidities) and the possible influence of Covid-19 pandemic on AN admission and hospital stay.
Methods: for the purpose of the study, we included children aged less than 18 years, admitted to IRCCS Bambino Gesù Children Hospital, Rome, Italy, with a diagnosis of AN. Medical costs were calculated consulting the Lazio Regional Health Service Tariffs. Basing on the date of hospital admission, patients were later divided into two subgroups: subgroup A included patients hospitalized prior than Covid-19 onset (from March 2019 to February 2020) and subgroup B those admitted after (from March 2020 to October 2022).
Results: a total of 260 patients has been included in the study with a median age of 15 years (range 6-18 years). The total health care cost of AN hospitalized patients was of EUR 3,352,333 with a median cost of EUR 11,124 for each admission (range EUR 930-45,739) and a median daily cost of EUR 593 (range EUR 557-930). Median cost was higher in case of comorbidities, guarded patients, enteral feeding. A prolonged hospitalization has been documented in subgroup A with a higher economic burden.
Conclusions: the economic burden of eating disorders is of note. Adequate sanitary policies as well as health economic analyses are required to gain insight into the cost-effectiveness of AN management.
Trial registration: 2526-OPBG-2021
The effect of eight weeks of respiratory muscle training on respiratory indices and the performance in adolescent male swimmers: A randomized control trial
Authors: Ghannadi Shima , Ghazalian Farshad , Niyazi Sepideh , Hasannejad Alireza , Shahi Mohammad Hossein Pourgharib , Ordibehesht Seyed Ashkan 
Published: January 2024

Abstract
Background: Improvement in the strength of respiratory muscles following inspiratory muscle training (IMT) has been seen in the majority types of athletes. Still, there are contradictory results of its effect on the athletes' performance, especially swimmers. The study aimed to evaluate the effect of the IMT program along with other routine exercises in increasing the performance of adolescent swimmers.
Methods: The present study was conducted on professional swimmers who were divided into intervention and control groups. Both groups had identical routine training in their team's camp. The intervention group was prescribed eight weeks of progressive IMT with a starting strength of 30% MIP daily, twice a day for three sets of 15 repetitions per set with a threshold resistance device. The control group trained with 15% maximum inspiratory pressure (MIP) constantly. Spirometric indices, MIP, and the swimming fifty meters' personal best time (50 meters PBT) were assessed before and after the trial.
Results: A total of 20 adolescent male swimmers (mean age 13.05(2.01) years; body mass index 19.85(2.31) kg/m2) were included in the study. The strength of inspiratory muscles, forced expiratory volume in the first second (FEV1) and 50meters PBT were significantly improved in the intervention group (p<0.005), however, forced vital capacity (FVC) and FEV1/EVC had no significant improvement compared to the control group (p>0.005).
Conclusion: Findings indicate the importance of using IMT in the process of swimming education and could help coaches provide swimmers with more effective IMT protocols to maximize the benefits of training.
Experimental autoimmune encephalomyelitis reduces the immunomodulatory properties of mesenchymal stem cells
Authors: Yeganeh Alireza , Ajamian Farzam , Farrokhi Sheida , Heidari Neda , Fathollahi Anwar , Hashemi Seyed Mahmoud , Yeganeh Farshid 
Published: January 2024

Abstract
Introduction: The impact of disease conditions on the differentiation capability of mesenchymal stem cells (MSCs) has been studied well. However, how disease-related alterations in MSCs affect the immune response has not been reported.
Materials & Methods: MSCs were isolated from adipose tissue of healthy and experimental autoimmune encephalomyelitis (EAE) mice and cultured in DMEM media with or without lipopolysaccharides (LPS, 10 ng/mL) preconditioning. The effects of MSC-conditioned media (CM) on the recall responses of splenocytes isolated from EAE mice were evaluated in vitro.
Results: MSCs obtained from healthy mice produced more IL-10 than those isolated from EAE mice, but no difference in TGF-β production was observed. The expression of Foxp3 and Gata3 transcription factors, as well as IL-10 and NO levels in the splenocytes of EAE mice that were treated with MSC-CM of EAE mice, were significantly lower than in cells treated with MSC-CM of healthy mice. Moreover, results showed that the mRNA level of RORγt and production of IL-17a by splenocytes of EAE mice after treatment with MSC-CM of EAE mice was significantly higher in comparison to splenocytes that were treated with healthy MSC-CM. However, the mRNA expression level of T-bet and the concentration of IFN-γ were statistically similar in splenocyte culture after treatment with MSC-CM of healthy and EAE mice.
Conclusion: Results revealed that MSCs of EAE mice had a lower ability to upregulate Foxp3 mRNA and down-modulate recall immune responses of EAE splenocytes that were restimulated with MOG35-55 than healthy MSCs.