bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Usia, Jenis Kelamin dan Asupan Garam dengan Tekanan Darah Penderita Hipertensi
Authors: Sari HS Senja Atika , Hasanah Uswatun , Fitri Nuri Luthfiatil , Nurhayati Sri , Yusri Viki 
Published: November 2023

ABSTRACT Hypertension, known as the 'silent-killer', affects more than 1.3 billion people in the world, 1 in 4 men and 1 in 5 women suffer from this disease. Hypertension has caused various serious impacts such as heart failure and coronary heart disease and even stroke. The risk factors that cause hypertension are multi-factorial, so this disease must be a concern. The purpose of this study was to determine the relationship between age, gender and salt intake with blood pressure of hypertension sufferers in the Banjarsari Health Center. This type of research is an analytic study with a cross-sectional design. The population in this study were patients with primary hypertension, the samples taken were 42 people. Analysis using chi square test. Patients with hypertension were dominated by age <60 years (69.0%), female gender (73.8%), and not limiting salt intake behavior (54.8%), blood pressure generally being at grade II (42.8%). 9%). The results of the analysis showed that there was a relationship between age (p-value 0.038; OR: 6.769) and salt intake (p-value 0.035; OR: 4.857) with blood pressure in patients with hypertension. Meanwhile, gender was not shown to have a significant relationship with blood pressure (p-value 0.731). It is hoped that people with hypertension can apply a healthy lifestyle such as doing physical activity and limiting salt intake. Keywords: Age, Gender, Salt Intake, Blood Pressure ABSTRAK Hipertensi yang dikenal sebagai ‘silent-killer’ telah diderita oleh lebih dari 1,3 milyar penduduk dunia, 1 dari 4 pria dan 1 dari 5 wanita menderita penyakit ini. Hipertensi telah menimbulkan berbagai dampak yang cukup serius seperti gagal jantung dan penyakit jantung koroner dan bahkan stroke. Faktor resiko yang menyebabkan terjadinya hipertensi bersifat multi faktor sehingga penyakit ini harus menjadi perhatian. Tujuan penelitian ini adalah untuk mengetahui hubungan usia, jenis kelamin dan asupan garam dengan tekanan darah penderita hipertensi di Wilayah Kerja Puskesmas Banjarsari. Jenis penelitian studi analitik rancangan crossectional. Populasi dalam penelitian ini adalah penderita hipertensi primer, sampel yang diambil sebanyak 42 orang. Analisis menggunakan uji chi square. Penderita hipertensi didominasi usia <60 tahun (69,0%), jenis kelamin perempuan (73,8%), dan memiliki perilaku tidak membatasi asupan garam (54,8%), tekanan darah uumumnya berada pada derajat II (42,9%). Hasil analisis menunjukkan ada hubungan usia (p-value 0,038; OR: 6,769) dan asupan garam (p-value 0,035; OR: 4,857) dengan tekanan darah pada penderita hipertensi. Sementara jenis kelamin tidak terbukti memiliki hubungan signifikan dengan tekanan darah (p-value 0,731). Diharapkan penderita hipertensi dapat menerapkan pola hidup sehat seperti melakukan aktivitas fisik dan membatasi asupan garam. Kata Kunci: Usia, Jenis Kelamin, Asupan Garam, Tekanan Darah
The Effect of Manggist Skin Juice on The Stability of Blood Sugar Levels in Diabetes Mellitus (DM) Patients
Authors: Batubara Khairunnisa , Sinaga Elvipson , Sianturi Marta Imelad Br. , Siregar Henrianto Karolus 
Published: November 2023

ABSTRACT Blood sugar level refers to the level of glucose in the blood. One that can maintain stable blood sugar levels is mangosteen peel juice, because mangosteen peel juice contains xantones and flavonoids that stabilize blood sugar levels. This study aims to determine the effect of mangosteen peel juice on the stability of blood sugar levels in diabetes mellitus patients at the Public Health Center Sibolangit. The design of this research is Quasi Experiment Design using One-group pretest posttest design. The sample in this study were 10 patients using purposive sampling. Data analysis used Paired Sample T-Test. The results showed that the P-value was 0.027 (P-value <0.05) so it could be concluded that there was an effect of giving mangosteen rind juice on the stability of blood sugar levels in diabetes mellitus patients at the Sibolangit Health Center. Mangosteen peel juice is one of the herbal medicines that can lower blood sugar levels in Diabetes Mellitus patients. Keywords: Juice Mangosteen Skin, The Stability of Blood Sugar Levels
Concentración de monóxido y dióxido de carbono en el proceso de soldadura con electrodo revestido
Authors: Flores Andino Víctor Manuel , Chávez Cascante Juan Carlos , Gómez Jaramillo María Ángela , Pérez Insuasti Juan José 
Published: November 2023

Introducción: La exposición a agentes contaminantes en las áreas de trabajo de los talleres de metalmecánica, es un riesgo constante al que se someten los trabajadores dedicados a realizar estas actividades. Objetivo: En el presente caso de estudio, se evaluó la concentración de dióxido de carbono y monóxido de carbono, en el proceso de soldadura de un condón continuo de una viga metálica. Metodología: La metodología aplicada, se basa a la norma UNE-EN 689, que establece los criterios necesarios, para el muestreo y evaluación de gases a valores umbrales. Se realizó lecturas casi instantáneas, de acuerdo con cada variación de los datos medidos a través del analizador Auto-Plus 4-2 modelo Kane. El tipo de suelda fue SMAW, con electrodo revestido 6011 a 78A y 220V. Resultados: Los resultados evidencian que, los niveles de concentración del monóxido de carbono, supera los niveles umbrales de exposición establecidos por organismos internacionales. Conclusión: Las emisiones de los gases no deben superar los 30cm medidos desde el punto de suelda, para lo cual, se recomienda mejorar los sistemas de ventilación. Área de estudio general: Ingeniería, Industria y Construcción. Área de estudio específica: Procesos de soldadura.
“THE DAY OF WRATH” BY YURII KOSACH: MODERNIZATION OF THE HISTORICAL NOVEL
Authors: Василенко Вадим 
Published: November 2023

The novel “The Day of Wrath” by Yurii Kosach is a modernist literary experiment, which reflected genre and stylistic searches of the late 1940s and the features of the individual creative and ideological evolution of the writer. The novel by Kosach attempts to question Polish and Russian imperial views on the events and the era of the Ukrainian Cossack Revolution, as well as to discard established social and religious concepts in favor of a national-cultural one.
The novelty of Kosach’s literary technique in the novel lies, in particular, in the method of kaleidoscopic arrangement of material chosen by the author, the specific alternation of images and situations, the incorporation of cinematographic elements, and the utilization of the ‘stream of consciousness’ technique. There are elements of baroque, romantic, and expressionist poetics in the structure of Kosach’s novel, and it’s the syncretism of these stylistic trends that underlies the uniqueness of Kosach’s author’s style. His works are marked with ornamentality, complicated associativity, the motif of duality, and the special function of the metaphor. These features bring Kosach’s writings closer to baroque poetics. Kosach’s “Day of Wrath” is also connected with the tradition of the romantic historical novel through the use of typical romantic images, schemes, and situations, which the author attempts to modernize. The expressionistic stylistic tendencies are evident in “The Day of Wrath” at the linguistic level, characterized by fragmentary writing, elliptical sentences, and a deliberate violation of syntax. These tendencies also manifest themselves in the means and techniques used for image and form creation. The paper highlights the characteristics of Kosach’s ideological and literary interpretation of Bohdan Khmelnytskyi’s image. The hetman is portrayed as a historical figure, a "baroque man," and a statesman-demiurge. Yurii Kosach created a sample of the historical novel, resonating with his time and his own historical and literary views. In order to fulfil this task, he updated its content and form, making some changes in genre and narrative canons.
Understanding the Background of Personality Disorders and the Influence of Early Experiences with Parents to their View of God
Authors: Pranata Lanny 
Published: November 2023

Early relationship is very significant in developing a healthy personality. What a child experience during first three years of life can have a lifelong impact. Early relationships not only act as a template of the brain, but also mold and shape the child’s ability for future relationships with others. Early relationship also becomes the determinant of normal or pathological splitting. Splitting is universal and not all splitting cause a pathology. Maternal-availability is essential during first three years of life. Normal splitting can happen when good-enough mother on some occasion is unavailable or unable to attend to the infant and meet his needs. The child can tolerate the good-enough mother’s unavailability at certain times because he or she is in ‘holding environment’ that makes the child feel secure, protected, and not excessively frustrated. Pathological splitting can happen when the infant receives excessively unsatisfying, frustrating and abusive experience. Severe splitting makes one to see everything in terms of black and white. He or she is not able to accept bad and good at the same time or cannot accept paradoxical qualities in others. A normal person can accept this paradoxical quality, but a personality disorder person cannot accept this paradoxical quality. Finally, early relationships influence one’s relationship to God, how he or she sees God and experience God. Three studies have found that early relationship with parents, whether secure or insecure relationships can influence how one sees God and relates to God (Gravitt, 2011; Pehr Granqvist, 2007; Rosalinda Cassibba, 2013). One who has a secure attachment with his or her parent, tend to trust God and has a secure relationship with God as well. As a therapist, it is essential that we provide a secure base for our patients or clients. Psychodynamic therapy is the kind of therapy that proved to help patients with Personality Disorders. Successful treatment should not only relieve symptoms but also make intrapsychic change by providing patients with a relationship that enables them to resolve the splitting of their ego.
E670G PCSK9 polymorphism in HeFH & CAD with diabetes: is the bridge to personalized therapy within reach?
Authors: Alieva Rano , Shek Aleksandr , Abdullaev Alisher , Fozilov Khurshid , Khoshimov Shovkat , Abdullaeva Guzal , Zakirova Dariya , Kurbanova Rano , Kan Lilia , Kim Andrey 
Published: November 2023

ObjectiveTo assess the distribution of PCSK9 E670G genetic polymorphism and PCSK9 levels in patients with Coronary Artery Disease (CAD) and Heterozygous Familial Hypercholesterolemia (HeFH), based on the presence of type 2 Diabetes Mellitus (T2DM).MethodsThe study included 201 patients with chronic CAD, including those with HeFH (n=57, group I) and without it (n=144, group II). DLCN was used to diagnose HeFH. The PCSK9 E670G (rs505151) polymorphism was genetically typed using the PCR-RFLP procedure. In both the patient and control groups, the genotype frequency matched the Hardy-Weinberg equilibrium distribution (P&gt;0.05).ResultsThere were twice more G alleles in group I (13, 11.4%) than in group II (17, 6.0%), and thrice more (1, 3.0%) than in the healthy control group; nevertheless, these differences weren’t statistically significant. Simultaneously, PCSK9 levels were higher in HeFH patients (P&lt;0.05) compared to non-HeFH patients not taking statins (n=63). T2DM was equally represented in groups I and II (31.6% vs. 33.3%). But carriers of AG+GG genotypes in group I had a higher chance of having a history of T2DM (RR 4.18; 95%CI 2.19-8.0; P&lt;0.001), myocardial infarction (RR 1.79; 95%CI 1.18-2.73; P&lt;0.05), and revascularization (RR 12.6; 95%CI 4.06-38.8; P&lt;0.01), than AA carriers. T2DM was also more common among G allele carriers (RR 1.85; 95% CI 1.11-3.06; P&lt;0.05) in patients with non-HeFH.ConclusionT2DM in patients with CAD, both with HeFH and non-HeFH, in the Uzbek population was significantly more often associated with the presence of the “gain-of-function” G allele of the PCSK9 E670G genetic polymorphism.
Towards net-zero: CO2 capture and biogas purification through electric potential swing desorption to achieve SDGs 7 and 13
Authors: Farooq Muhammad , Rehman Ateekh Ur , Anwer Izza , Imran Muhammad , Pettinau Alberto , Andresen John M. 
Published: November 2023

Currently, the potential of biomethane derived from biogas is substantial, positioning it to fulfill a considerable share of the United Kingdom’s total energy needs. The primary challenge associated with raw biogas lies in purifying it to produce biomethane, a process that necessitates the removal of carbon dioxide and hydrogen sulfide. Among the various methods, adsorption of activated carbon (AC) stands out as a particularly effective and cost-efficient approach for converting biogas into biomethane, provided that the regeneration of AC proves economically viable. In this research, a segment of activated carbon was utilized to assess the adsorption properties when exposed to a gas mixture of CO2, H2S, and N2 within a regenerative activated carbon setup. This investigation encompassed the analysis of adsorption and desorption behaviors, process capacities, and the impact of regeneration. To enhance the adsorption of CO2, electro-conductive polymers (ECPs) were incorporated into the AC samples, leading to an extension in breakthrough time. Subsequent to adsorption, the electric potential swing desorption (EPSD) was employed for in situ regeneration of activated carbon samples, involving potentials of up to 30 V. The findings exhibited that the newly introduced EPSD technique considerably diminished desorption durations for both H2S and CO2. Moreover, it successfully rejuvenated the accessible adsorption sites, resulting in reduced desorption times compared to the initial breakthrough time during adsorption. Consequently, the EPSD system proves to be a promising candidate for in situ regeneration of activated carbon to eliminate CO2 and H2S from biogas. Notably, this approach offers inherent advantages over conventional methods including thermal swing adsorption (TSA) and pressure swing adsorption (PSA) in terms of regeneration. The demonstrated method underscores the potential for more efficient and economically viable cycles of adsorption and desorption, thereby enhancing the overall biogas-to-biomethane conversion process to achieve SDGs 7 and 13 for clean and green energy applications.
Relationship between driver gene mutations and clinical pathological characteristics in older lung adenocarcinoma
Authors: Liu Xia , Jiang Guopeng , Sun Xuefei , Su Guangfeng , Zhang Xuan , Shen Dan , Yan Na 
Published: November 2023

ObjectivesLung adenocarcinoma (LUAD) is the most common newly diagnosed malignant tumor in older people. As older patients age, organ function decreases, leading to increased adverse reactions to treatment. The epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase tyrosine (ALK) tyrosine kinase inhibitors (TKIs) therapy are more effective and well-tolerated than chemotherapy, while the rate of genetic testing and subsequent targeted treatment among older patients remains relatively low, the clinical benefit limitation for those patients. This study aims to investigate the mutation characteristics of LUAD diver gene and its relationship with clinicopathological features in older LUAD.Materials and methodsA total of 275 patients were diagnosed as LUAD and were over sixty years old. We utilized next-generation sequencing technology to detect and analyze gene mutations in postoperative tissue specimens, including EGFR, KRAS, ALK, ROS1, RET, MET, BRAF, HER2, PIK3CA and NRAS.ResultsA total of 90.18% (248/275) of older LUAD patients experienced genetic mutations. The EGFR (192, 69.82%) had the highest mutation rate among ten genes, followed by KRAS (21, 7.64%), MET (21, 7.64%), ERBB2 (15, 5.45%), RET (9, 3.27%), ALK (8, 2.91%), ROS1 (8, 2.91%), PIK3CA (6, 2.18%), BRAF (5, 1.82%) and NRAS (1, 0.36%). We also found thirty patients (15.63%) with EGFR mutations also having other gene mutations. The L858R mutation and exon19 deletion were the predominant EGFR mutations, accounting for 84.90% of EGFR-mutated patients. In addition, fifty-one kinds of EGFR mutations were detected, distributed in the protein tyrosine kinase catalytic domain (43, 84.31%), cysteine enriched domain (4, 7.84%), receptor binding domain (3, 5.88%), and EGFR transmembrane domain (1,1.96%). Ten cases of gene fusion mutation were detected. Two rare partner genes, PKHD1 (P60:R34) and STK39 (R33:S11), were detected by ROS1 gene fusion. RET gene fusion revealed a rare companion gene KCND2 (R11:K2). The EGFR mutations were more prevalent in female, non-smoking patients (p &lt; 0.05), and the KRAS mutations were more common in male and smoking patients (p &lt; 0.01). In addition, the BRAF mutations were more likely to occur in the right lung (p &lt; 0.05).ConclusionOlder LUAD populations exhibit diverse genetic mutations, which may also exist simultaneously. Simultaneous detection of multiple genes by NGS can accelerate and enhance targeted treatment benefits for older LUAD patients, ultimately improving their quality of life.
Development and clinimetric assessment of a performance-based functional vision tool in visually impaired children
Authors: Ghasemi Fard Fatemeh , Mirzaei Hooshang , Hosseini Seyed Ali , Riazi Abbas , Ebadi Abbas , Hooshmandzadeh Narges 
Published: November 2023

ObjectiveAppropriate functional vision is vital for the development of visually impaired (VI) children. However, the literature currently lacks a performance-based tool for assessing functional vision, unlike the existing self-reported tools. The objective of this study is to develop and conduct a clinimetric study on a Performance-Based Functional Vision Tool (PB-FVT) specifically designed for VI children aged 3–7 and 7–10 years old.MethodsThis methodological study was conducted to assess the clinimetric properties of the PB-FVT. The assessment included face validity (evaluated through cognitive interviews and an Impact Score &gt;1.5), content validity (with criteria including content validity ratio &gt;0.63, item content validity index &gt;0.78, scale content validity index or average &gt;0.8, and Kappa value &gt;0.7), criterion validity (assessed through a concurrent test using visual acuity scores), construct validity (utilizing the known group method), relative reliability (measured by the intra-class correlation coefficient), absolute reliability (determined by the standard error of measurement and minimal detectable changes), interpretability, responsiveness, sensitivity, and specificity (analyzed via ROC curve analysis).ResultsThe PB-FVT was developed with 32 items, divided into five components: activities of daily living, instrumental activities of daily living, education, play, and social interaction. The results indicate that the scale demonstrates suitability in terms of validity, reliability, and other measurement characteristics.ConclusionsThe valid and reliable PB-FVT may accurately assess the level of functional vision during early childhood, helping to prevent negative impacts on a child's overall development. By utilizing the PB-FVT, any functional vision impairments can be identified appropriately, enabling the planning and implementation of effective rehabilitation interventions.
Phonological discrimination and contrast detection in pupillometry
Authors: Chiossi Julia S. C. , Patou François , Ng Elaine Hoi Ning , Faulkner Kathleen F. , Lyxell Björn 
Published: November 2023

IntroductionThe perception of phonemes is guided by both low-level acoustic cues and high-level linguistic context. However, differentiating between these two types of processing can be challenging. In this study, we explore the utility of pupillometry as a tool to investigate both low- and high-level processing of phonological stimuli, with a particular focus on its ability to capture novelty detection and cognitive processing during speech perception.MethodsPupillometric traces were recorded from a sample of 22 Danish-speaking adults, with self-reported normal hearing, while performing two phonological-contrast perception tasks: a nonword discrimination task, which included minimal-pair combinations specific to the Danish language, and a nonword detection task involving the detection of phonologically modified words within sentences. The study explored the perception of contrasts in both unprocessed speech and degraded speech input, processed with a vocoder.ResultsNo difference in peak pupil dilation was observed when the contrast occurred between two isolated nonwords in the nonword discrimination task. For unprocessed speech, higher peak pupil dilations were measured when phonologically modified words were detected within a sentence compared to sentences without the nonwords. For vocoded speech, higher peak pupil dilation was observed for sentence stimuli, but not for the isolated nonwords, although performance decreased similarly for both tasks.ConclusionOur findings demonstrate the complexity of pupil dynamics in the presence of acoustic and phonological manipulation. Pupil responses seemed to reflect higher-level cognitive and lexical processing related to phonological perception rather than low-level perception of acoustic cues. However, the incorporation of multiple talkers in the stimuli, coupled with the relatively low task complexity, may have affected the pupil dilation.
Des stages pour les ouvriers immigrés du bâtiment trois organismes collaborent à une definition de la formation
Authors: Auger Anne-marie 
Published: November 2023

À la suite de la publication de la circulaire du 21 mai 1975, le GFC-BTP (Groupement Formation Continue-Bâtiment Travaux Publics ) a financé, par l'intermédiaire de ses antennes régionales, AREF, un certain nombre de stages, en continu, pris sur le temps de travail, pour les travailleurs immigrés.
Nous présentons deux formules de stages AREF, expérimentés en 1975-76 : l'une de formation très ouverte, mise sur pied, à Toulouse, par trois organismes, travaillant en collaboration étroite sur le terrain ; l'autre, liée à l'Education Nationale, et tournée surtout vers un approfondissement des activités professionnelles.