bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaborative Assembly Sequence Planning (CASP) based on data analysis for On-site Installation Products
Authors: Vélez Pedro , Uribe Alejandro , Aristizabal Sergio , Osorio Gilberto 
Published: October 2023

Abstract

For the manufacture of significantly repetitive products that require assembly, different strategies have been proposed to improve times, the use of resources, and the reduction of associated costs. For this purpose, there are many documented methodologies that point to method and time studies, reduction of the number of components or the complexity of the assembly as the \acrfull{DFA}, sequence analysis with \acrfull{ASP}, Bourjault, and/or graphs, among others.In the case of products that require to be assembled at the site where they will operate, manufacturing in a fixed position, and of which several assemblies will be performed in different places, the execution of these has been done, almost always, in an intuitive way, that is, solving on the fly, starting from common sense and accumulating parts. The existing literature has limited information on the methods developed for assembly with these characteristics.This study presents a new methodology of sequence generation called \acrfull{CASP} for the on-site installation of a product in which, the criteria and knowledge of a group of engineers are considered, helping to identify the assembly operations, the sequences, the arrangement and allocation of resources and tasks for the development of the assembly.Additionally, this methodology is verified in a case study applied to a photovoltaic charging station, for which a feasible, effective, detailed, and structured assembly sequence was collaboratively generated for the assembly of such a product. The results show the applicability of the \Gls{CASP} methodology and suggest that it could be applied in other complex product assembly contexts requiring on-site assembly.
Development of a preliminary bionematicide formulation with Pochonia chlamydosporia and its effectiveness against Meloidogyne javanica on tomato
Authors: Imani Saeid , Moosavi Mohammad Reza , Zare Rasoul , Basirnia Tahere 
Published: October 2023

Abstract
Developing a bionematicide formulation was the aim of this experiment. We evaluated chlamydospore production of three Pochonia chlamydosporia strains on flaxseed and rice-husk, and their survival on talc, kaolin and maize-cobs-powder. The effect of each formulations in suppressing Meloidogyne javanica on tomato was investigated in greenhouse. The number of chlamydospores on flaxseed was about twice more than on rice husk for all strains. IRAN 1212C produced more chlamydospores with longer lifespan compared with the other strains. IRAN 1212C on maize-cobs-powder could control M. javanica by 95% that was similar to fluopyram. This formulation had a superior effect in establishing the fungus in the rizhosphere and on roots, suppressing the nematode and increasing plant growth. Three strains of the fungus reproduced well on flaxseed and could last longer if formulated on maize cobs powder. Therefore, maize cobs powder can be suitable base to produce on effective powdered bionematicide.
Coenzyme Q10 Loaded DQAsomes for Leigh Disease
Authors: ERGİN Ahmet Doğan , SEÇEN Erhan , UNER Burcu , ÇELİK Aybuke 
Published: October 2023

Abstract
Leigh syndrome (LS), a rare hereditary neurometabolic disorder caused by mitochondrial dysfunction, results from genetic mutations affecting the central nervous system. Endogenous bioactive antioxidant Coenzyme Q10 (CoQ10) deficiency is associated with LS and contributes to various clinical symptoms. Dequalinium chloride (DQA) is a bolalipid with mitochondria-targeting properties. This study aimed to develop CoQ10-loaded DQAsomes to enhance CoQ10 solubility and delivery to mitochondria for potential LS treatment. Human pluripotent cell lines (HPP) and MDCi007-A cells with NDUFV gene anomalies were utilized. DQAsomes were prepared using thin-film technique and characterized for size, zeta potential, encapsulation efficiency, and process efficiency. Drug release, dissolution, and cytotoxicity studies were performed. RT-PCR, ELISA, immunostaining, and Western blot analyses assessed pluripotency and gene expression changes and apoptosis induced by the formulations. DQAsomes exhibited sizes between 165.8-311.2 nm, with anionic zeta potential. Encapsulation efficiency ranged from 34.03–82.48%. Cytotoxicity studies demonstrated improved viability with CoQ10-DQA compared to CoQ10-PBS. CoQ10-DQAsignificantly reduced the expression of pluripotency markers OCT3/4, SOX-2, and NANOG, potentially indicating reduced stemness. CoQ10-loaded DQAsomes present a promising strategy for addressing CoQ10 deficiency in LS. These DQAsomes enhance CoQ10 solubility and bioavailability while potentially modulating cellular pluripotency markers and mitochondrial gene expression.
Prediction of carbon peak in Tacheng, China, based on the LEAP model
Authors: Pengxiang Chen , Dongmei Peng , An Yan 
Published: October 2023

Abstract

As carbon emissions are the major cause of global warming, several researchers have focused on formulating regional emission reduction paths. This study measured the energy carbon emissions in Tacheng, Xinjiang, China, using the emission coefficient method. The long-range energy alternatives planning (LEAP) model was combined with the scenario analysis method to simulate the carbon emissions, predict the carbon peak time and carbon emission peak, and analyze the carbon peak realization path in Tacheng for 2021–2035. The results showed that the scheduled carbon peaking goal could be achieved only when emission reduction measures were jointly implemented in the energy-saving, green electricity, and industrial structure adjustment scenarios. Moreover, during the 14th Five-Year Plan, pressures will increase on energy consumption and carbon emission control. Further, pressures on the industry, service, and transportation sectors to reduce emissions were significantly greater than that on the agricultural and household sectors. The pressure of carbon peak in the agricultural sector was relatively small. Further, the average emission reduction potential of industrial, agricultural, service, household, and transportation sectors was 23.75%, 8.55%, 29.07%, 24.82%, and 13.82%, respectively. During the 14th Five-Year Plan, energy-saving and emission reduction measures should be employed in the industrial and service sectors. The average emission reduction potentials of coal, oil, and gas as energy sources indicated that reducing coal consumption and increasing the energy efficiency are key carbon peaking measures in Tacheng. Based on the results, several suggestions were proposed to reach the carbon peak and neutrality goals in Tacheng possibly countries as well.
Motor function and treatment satisfaction in adult patients with 5q-spinal muscular atrophy treated with risdiplam: real-world experience from a single neuromuscular center in Germany
Authors: Bjelica Bogdan , Wohnrade Camilla , Cespedes Iraima , Osmanovic Alma , Schreiber-Katz Olivia , Petri Susanne 
Published: October 2023

Abstract
Background
To date, there are only two previous reports on motor function during risdiplam therapy in adult patients with spinal muscular atrophy (SMA) in a real-world setting, each comprising six patients with SMA type 2. We aimed to describe the experience of a single neuromuscular center in Germany in treating adult SMA patients with risdiplam and to analyze motor function and treatment satisfaction during a follow-up period up to 20 months.
Methods
Fourteen patients with type 2 or 3 SMA (seven with SMA type 2, six with SMA type 3; age range: 18–51) were included. The Revised Upper Limb Module (RULM) and the Hammersmith Functional Motor Scale Expanded (HFMSE) were recorded at baseline and at follow-up (month 4, 8, 12, 16, 20). Treatment adverse events were collected at every follow-up visit. Patients’ treatment satisfaction was assessed by the Treatment Satisfaction Questionnaire for Medication (TSQM).
Results
No significant differences were detected between mean HFMSE and RULM scores obtained at baseline and during risdiplam treatment (p > 0.05). Based on the HFMSE score, no patients had clinically meaningful improvement. Twelve remained stable (92.3%), two showed transient clinically meaningful deterioration (15.4%) and one experienced lasting clinically meaningful deterioration (7.7%). Based on the RULM scores, seven patients were either stable or demonstrated clinically meaningful improvement (53.8%) and six showed clinically meaningful deterioration (46.2%). There was no treatment withdrawal during the follow-up. The most common adverse events were skin rash/increased skin sensitivity to sunlight (n = 3), diarrhea (n = 3), aphthous ulcer (n = 3) and abdominal pain (n = 2). Most patients stated to be at least “satisfied” with the medication.
Conclusions
Risdiplam was well tolerated. Half of the patients remained stable or improved after risdiplam initiation. Larger and multicentric studies are needed to better understand the long-term effects of risdiplam in adult SMA.
Expansive haematoma following buccal fat pad reduction: An unusual case report
Authors: Santos José Wittor de Macêdo , Júnior Otacílio Luiz Chagas , Muniz Franciso Wilker Mustafa Gomes 
Published: October 2023

Abstract

The buccal fat pad, an intricate anatomical structure, can be used to manage minor to moderate oral defects and, by your removal, address parafunctional habits leading to intraoral trauma. It also serves aesthetic purposes through reduction. Buccal fat pad reduction is typically a swift, safe procedure with a low complication rate. This report aims to illuminate an unusual case involving a later expansive hematoma following buccal fat pad reduction surgery. This complication posed a potential airway threat and led to severe trismus. Notably, our team effectively managed these issues using minimally invasive methods such as drainage, compression, and medication. This case serves as a vital reminder that late bleeding and expansive hematoma formation are possible outcomes, even when performed by a skilled surgeon. This case also highlights the feasibility of treating substantial hematomas originating from veins without the need for invasive procedures. This report underscores the importance of vigilance in these cases to ensure patient safety.
Clinical, Ultrasound and Anatomopathological Concordance of Thyroid Nodules in Kinshasa: A Cross-sectional study
Authors: Kumbu Jacques Mbizi , Nkodila Aliocha Natuhoyila , Kuzeye Jules Nakafwako , Minouche Cynthia Bokumba , Molua Antoine Aundu , Mbongo Angel Tanzia , Bisuta Serge Fueza , Lessenge Jacquie Bonsuani , Kisile Olive Mikwo , Sitwaminya Renault , Beya Francois Kabongo , Ali Cathy Risasi , Nsadi Berthier Fwene , Mbaya Malik Kayembe , Mpa Olivier Nzankulu , Omba Alain Wembolwa , Tsasa Erick Mbuku , Tsongo Sosthene Vululi , Kiabaka Honoré Yambula , Makelele Raoul Vindu , Lelo Michel Tshikwela , Mukaya Jean Tshibola 
Published: October 2023

Abstract

Background: The European Thyroid Association Thyroid Imaging Data and Reporting Systems (EU-TIRADS) is widely used in the risk stratification of thyroid nodule malignancy. However, data on the subject in Sub-Saharan Africa are limited. The objective of this study is to evaluate the clinical, sonographic and histopathological concordance of thyroid nodules in the diagnosis of thyroid cancer.
Methods: this was an analytical cross-sectional study that examined the clinical, ultrasound and pathological data of 61 patients from 4 hospitals in the city province of Kinshasa over a period of 24 months, from June 01, 2020 to May 31, 2022.
Results: Of the 61 patients, their mean age was 47.38 ± 8.8 years. The mean clinical score of the patients was 3.4 ± 0.84 with the extremes ranging from 1 to 5. The majority of the patients were classified as having an intermediate risk, ie 85.2% of the cases. It was noted that 41% of the nodules had a high risk according to the EU-TIRADS score and 8.2% of the nodules were malignant after histopathological analysis. The ROC curves reported at the diagnosis of malignancy show an area under the curve of 0.709 with 95% CI (0.486-0.931), a Youden index of 0.769 for the clinical score, and an area under the curve of 0.830 with 95% CI (0.605-0.995), a Youden index of 0.772 for the EU-TIRADS score.
Conclusion: In a low-income country, a well-performed thyroid ultrasound and the well-applied clinical score could be an important tool in the selection of thyroid nodules suspected of malignancy and requiring histopathological examination to avoid excessive acts in the patient.
O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
Authors: Zhu Wenge , ZHANG YI , Zhou Shuyan , Kai Yan , Zhang Ya-Qin , Peng Changmin , Li Zhuqing , mughal Muhammad , Ma Junfeng , Li Shunqiang , Ma Cynthia , Shen Min , Hall Matthew 
Published: October 2023

Abstract

Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-throughput combinatorial drug screening and genomic sequencing, we found that the microphthalmia-associated transcription factor (MITF) is activated via O-GlcNAcylation by O-GlcNAc transferase (OGT) in palbociclib-resistant breast cancer cells and tumors; O-GlcNAcylation of MITF at Serine 49 enhanced its interaction with importin α/β, thus promoting its translocation to nuclei, where it suppressed palbociclib-induced senescence; inhibition of MITF or its O-GlcNAcylation re-sensitized resistant cells to palbociclib. Remarkably, clinical studies confirmed the activation of MITF in tumors from patients who are palbociclib-resistant or undergoing palbociclib treatment. Collectively, our studies shed light on a novel mechanism regulating palbociclib-resistance, and present clinical evidence for developing therapeutic approaches to treat CDK4/6i-resistant breast cancer patients.
Significance: This work not only identifies a novel mechanism regulating MITF activity and resistance to CDK4/6 inhibitors in breast cancer cells, but also provides clinical evidence supporting the development of therapeutic approaches to treat CDK4/6i resistant breast cancer patients by targeting MITF.
A nanoporous capacitive electrochemical ratchet for continuous ion separations
Authors: Segev Gideon , Kautz Rylan , Herman Alon , Heffernan Ethan , Muñetón Camila , Larson David , III Joel Ager , Toma Francesca Maria , Ardo Shane 
Published: October 2023

Abstract

Directed ion transport in liquid electrolyte solutions underlies many phenomena in Nature and industry. While Nature has devised structures that drive continuous ion flow without Faradaic redox reactions, artificial analogs do not exist. Here we report the first demonstration of an ion pump that drives aqueous ions against a force using a capacitive ratchet mechanism that does not require redox reactions. Modulation of an electric potential between gold thin films on either face of a nanoporous alumina wafer immersed in solution resulted in persistent voltages and ionic currents indicative of directional ion pumping. This occurs due to the non-linear capacitive nature of electric double layers, whose repeated charging and discharging sustains a continuous ion flux. The generated ionic power was used in conjunction with an additional shunt pathway to demonstrate electrolyte demixing. These ratchet-based ion pumps can potentially enable continuous desalination and selective ion separation using a modular, electrically powered device with no moving parts.
Modular Industrial Robot Suitable for Various Scenarios
Authors: Wei Jiawei , Pan Yuzhen , Liu Caitian , Khan Rezwan Al Islam , Zhang Chenyun , Chen Xiong 
Published: October 2023

Abstract
This paper proposes a novel multi-scenario industrial robot designed to execute various activities, such as sorting, grasping, and transportation. Embracing a modular design philosophy, we design this robot with two types of robotic arms, three chassis options, and two motion systems, enabling the automatic transition among different operational modes and various work scenarios. Kinematic and dynamic models have been developed to achieve precise control over the movements of both the chassis and robotic arms, with control accuracy analyzed based on prototype parameters. The robot's performance accuracy and task completion have been evaluated through simulation assessments and physical tests, considering the physical parameters of different module combinations. The results demonstrate that, across various configurations, the robot attains an average control accuracy of 1.018 millimeters and achieves a task completion rate of 97.7% in simulated scenarios, underscoring its exceptional precision in control and dynamics. These findings are further substantiated through numerical experiments. This novel multi-scenario industrial robot presents a promising advancement in automation technology, potentially enhancing a wide range of industrial applications by offering high-precision, versatile capabilities in diverse work environments.
Software Fault Prediction Using Combinations of Code Smells, Code Metrics, and Code Smell Metrics With Ensemble and Deep Learning
Authors: Khan Tamim Ahmed , Ashraf Muzalfa 
Published: October 2023

Abstract
Code smells are the structural characteristics of the software under development that indicate poor code choices and can cause errors or failures in the software and they can degrade the software maintenance and evolution processes. Software fault prediction (SFP) helps predict the probability of the existence of software faults utilizing code characteristics and metrics. Code smells-based datasets are based on a variety of code measures such as information about the presence of certain code smells or a combination of code smells with code metrics and code smell metrics with code metrics. We investigate the effectiveness and usefulness of these different combinations for performance evaluation and improvement of SFP models. We label the unlabeled datasets using clustering and pseudo-labeling techniques. We implement models considering ensemble methods and deep learning algorithms and compare performance. We use k-fold cross-validation and our results outperform existing benchmark studies. We conclude that code smells-based software defect prediction has optimal accuracy and precision.
Glucocorticoid Replacement Therapy and Nocturnal Hypoglycemia in Adrenal Insufficiency Patients: A Case Series Study
Authors: Kanazawa Ken , Hijikata Mai , Koga Shinichiro , Kuwabara Koichiro 
Published: October 2023

Abstract
Background
Adrenal insufficiency (AI) is a hormonal disorder characterized by insufficient glucocorticoid production. Nocturnal hypoglycemia (NH) occurs in patients with AI. However, the relationship between AI and NH remains unclear. This study aimed to investigate the relationship between AI and NH by evaluating the impact of glucocorticoid replacement therapy (GCRT) on NH in patients newly diagnosed with AI.
Methods
This case series was conducted between October 2018 and December 2022 at the Department of Diabetes, Metabolism and Endocrinology of the Tokyo Rosai Hospital, Japan. In total, 15 patients aged ≥ 18 years with newly diagnosed AI or NH were included in this study. The NH frequency was measured using continuous glucose monitoring (CGM). The primary outcome was the change in NH frequency before and after the GCRT intervention.
Results
GCRT significantly decreased NH frequency. Severe NH (SNH) frequency and minimum nocturnal glucose levels changed significantly while fasting blood glucose and glycated hemoglobin levels did not change significantly. GCRT intervention improved CGM profiles’ time below range, time in range, and average daily risk range.
Conclusions
This case series suggests that GCRT can help newly diagnosed patients with AI manage NH. These findings show that CGM can determine the optimal GCRT dosage and prevent SNH. Our findings improve patient’s quality of life by enhancing AI-NH comprehension and treatment strategies. Further large multicenter studies should validate these findings and delve deeper into the mechanistic link between AI and NH.
Trial registration:
retrospectively registered
Thermal expansion of monoclinic KYbxY1-x(WO4)2 laser crystals
Authors: Yumashev K. V. , Trusova E. E. , Guretskii S. A. , Karpinsky D. V. , Trukhanova K. L. , Hertsova A. V. , Malyarevich A. M. 
Published: October 2023

Abstract
Potassium-yttrium tungstate single crystals KYbxY1-x(WO4)2 of high structural quality are grown by the modified Czochralski method. The crystals were grown using so-called dynamic growth regime, optimal temperature gradients at the crystallisation front were determined. The thermal expansion coefficients of KYbxY1-x(WO4)2 in the directions of the optical indicatrix axes Np, Nm and Ng are determined using the dilatometric technique. The dependence of thermal expansion coefficients on the temperature in the range of 330–573 K and ytterbium content x from 0 to 1.0 is discussed.
Prevalence of Undiagnosed Type 2 Diabetes Mellitus in Acute ST Elevation Myocardial Infarction
Authors: Ismail Muhammad Shamill Shamsul , Wahab Norasyikin A. , Hod Rozita , Hassan Hamat Hamdi Che , Md Rabizah 
Published: October 2023

Abstract
Background
The objective of this study was to determine the prevalence of undiagnosed type 2 diabetes mellitus (T2DM) in ST-elevated myocardial infarction (STEMI) patients.
Methods
A single-center cross-sectional study involving 85 STEMI patients was conducted at Hospital Canselor Tuanku Mukhriz (HCTM). The HbA1c and FBS were taken in all patients within 24 hours of admission. A coronary angiogram was performed immediately or within 5 days of the event and the severity of the finding was calculated by using syntax score.
Results
Of the 85 patients, 56.6% (48) had diabetes of which 34.1% (29) had known cases of T2DM and 22.4% (19) is a newly diagnosed diabetes by using HbA1c criteria > 6.5%. There was no significant difference between HbA1c and fasting insulin levels with CAD severity. The incidence of MACE at 1-month follow-up was not different between T2DM and non-diabetes patients. Male patients of Malay ethnicity and those with dyslipidemia and hypertension were significantly associated with a higher prevalence of undiagnosed T2DM among STEMI patients.
Conclusions
The prevalence of newly diagnosed T2DM at the onset of STEMI was 22.4%. The HbA1c was an effective tool in detecting diabetes among STEMI patients.
The perception of the Brazil plane (2 0 0) in M-type Cu1−xNaxO1 Nanocrystallite due to Na atom/ions doping derives Pyroelectricity application
Authors: Samaje Vishal , Kambhala Nagaiah , S Manikandan A , Thiyagaraj S 
Published: October 2023

Abstract
The hydrothermal approach was carried out to make sodium doped (atom wt. % 0.05, 0.15, 0.25) copper II oxide Nanocrystallite. The one-dimensional twinning/Brazil (2 0 0) plane in the direction of {1 1 0} has been identified in CuO Nanocrystallite space group (C2/c). The visibility of sharp intense peak appears at 19.09o (2-Theta) in powder X-ray diffraction pattern. The Monoclinic crystal structure of CuO provides the same Wyckoff site to Na atom/ions and hence the Na atom achieved the solubility limits up to 0.05 to 0.15 atomic weight percentage. The mean crystalline size has been determined using Scherer’s formula and the size range is in between 22 to 25 nm. From EDX analysis the atomic percentage of Cu decreases as doping (Na) concentration rises has been confirm, and it reveals that the Cu atoms have partially provide its Wyckoff site to Na atom / ions counterparts as content up to the certain limit. According to the optical observations, increasing the Na doping level causes an expansion of the energy band gap. SEM images confirm the rice grain nanostructure of the material.