bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fat Accumulation and Elevated Free Fatty Acid Are Associated With Age-Related Glucose Intolerance: Bunkyo Health Study
Authors: Naito Hitoshi , Kaga Hideyoshi , Someya Yuki , Tabata Hiroki , Kakehi Saori , Tajima Tsubasa , Ito Naoaki , Yamasaki Nozomu , Sato Motonori , Kadowaki Satoshi , Sugimoto Daisuke , Nishida Yuya , Kawamori Ryuzo , Watada Hirotaka , Tamura Yoshifumi 
Published: December 2023

Abstract

Context
Older adults have a high prevalence of new-onset diabetes, often attributed to age-related decreases in insulin sensitivity and secretion. It remains unclear whether both insulin sensitivity and secretion continue to deteriorate after age 65.

Objective
To investigate the effects of aging on glucose metabolism after age 65 and to identify its determinants.

Methods
This cross-sectional study involved 1438 Japanese older adults without diabetes. All participants underwent a 75-g oral glucose tolerance test (OGTT). Body composition and fat distribution were measured with dual-energy X-ray absorptiometry and magnetic resonance imaging. Participants were divided into 4 groups by age (65-69, 70-74, 75-79, and 80-84 years) to compare differences in metabolic parameters.

Results
Mean age and body mass index were 73.0 ± 5.4 years and 22.7 ± 3.0 kg/m2. The prevalence of newly diagnosed diabetes increased with age. Fasting glucose, fasting insulin, the area under the curve (AUC)-insulin/AUC-glucose and insulinogenic index were comparable between groups. AUC-glucose and AUC-insulin during OGTT were significantly higher and Matsuda index and disposition index (Matsuda index · AUC-insulin/AUC-glucose) were significantly lower in the age 80-84 group than in the age 65-69 group. Age-related fat accumulation, particularly increased visceral fat area (VFA), and elevated free fatty acid (FFA) levels were observed. Multiple regression revealed strong correlations of both Matsuda index and disposition index with VFA and FFA.

Conclusion
Glucose tolerance declined with age in Japanese older adults, possibly due to age-related insulin resistance and β-cell deterioration associated with fat accumulation and elevated FFA levels.
Fertile Grounds
Authors: Bottiger Patrick 
Published: December 2023

Abstract
From 300 CE to 1800 CE, Indigenous North Americans initiated a great material and cosmological transformation. Indigenous peoples moved away from their more nomadic lifestyles by mastering hydrology to manage crop cycles, engineering building systems to house their growing populations and food stores, and developing innovative political confederacies to harness the transformative and spiritual power of the Three Sisters. Through an examination of traditional ecological knowledge—what Gregory Cajete calls the “original instructions for how to care for and relate to the land”—this essay argues that the cultivation and spread of corn, beans, and squash radically remade Indigenous North America into a world bound by a set of relationships and reciprocal responsibilities between humans and plants. These plants were far more than commodities. They were kin—or, as plant ecologist Robin Wall Kimmerer says, “sovereign persons.” As Indigenous women spread the Three Sisters across the continent, these plants and the attendant corn cosmologies provided narratives to explain human ancestry and evolution. Such creation stories attracted Indigenous immigrants to Cahokia, Indigenous traders to the Mandan and Hidatsa rendezvous, and helped precipitate the rise of the Wendat, Haudenosaunee, and Powhatan confederacies.
THEORETICAL GENERALIZATION OF THE PROGRAM FOUNDATIONS FOR THE DEVELOPMENT OF INTELLIGENCE OF FUTURE OFFICERS IN THE CONDITIONS OF A MILITARY UNIVERSITY
Authors: Naumov Petr Y. 
Published: December 2023

Relevance. The development of the intelligence of a future officer in the educational environment of a military educational institution of higher education presupposes, among other things, the appropriate organization of the pedagogical process. This is necessary to achieve the desired results of training, education and development of personality traits of a cadet. To achieve the effective construction of the specified pedagogical process, it is necessary: firstly, not to overload the cadet with educational and educational activities, since the process of obtaining education in a military university is already quite intense; secondly, to use the potential of the educational subjects and educational events already built into the pedagogical process in the development of the intelligence of future officers; thirdly, to organically integrate author’s developments (program, courses, conditions) into the pedagogical process in order to solve problems of developing the intelligence of the future officer.
Materials and methods. In preparing and conducting the study, the methodological principles of a systematic, activity and subjective approach were applied. These approaches in this study perform organizational, epistemological, explanatory-content, structural-logical and prognostic functions. Within the framework of these approaches, various types of analysis and synthesis (systemic and functional, conceptual and structural-component), analogy and comparison, abstraction, hypothetical-deductive method are applied.
Results of the study. It has been established that the construction of a pedagogical process for the development of the intelligence of a future officer is based on the principles of consistency, complexity, continuity, dynamism, purposefulness, plasticity, algorithm city, cyclicality and is carried out in the following areas: organizational and programmatic; regulatory and legal; subject-communicative; meaningful; emotional and intellectual; valuable; activity-functional. The implementation of these areas involves the optimal combination of traditional and innovative forms of organization of the pedagogical process and the effective application of methods for its implementation, which correspond to the modern development of psychological and pedagogical science. When implementing the pedagogical process, taking into account diagnostic data, it is necessary to optimize and improve it. The design and implementation of the author’s features of the organization and implementation of the pedagogical process will make it possible to purposefully develop the psychological properties of the intelligence of the future officer in the educational environment of a military university.
POSSIBILITIES OF DIGITAL EDUCATIONAL TECHNOLOGIES AS A WAY OF ORGANIZING A DIGITAL EDUCATIONAL ENVIRONMENT
Authors: Alekseeva Elena E. 
Published: December 2023

The article reveals the concepts of digital technologies and digital educational technologies as a way of organizing a digital educational environment and a means of forming students’ universal skills that will be applicable in their future professional and personal growth.
The purpose of the article is to identify the possibilities of digital educational technologies, as well as the classification of digital resources and tools that contribute to improving the effectiveness of schoolchildren’s learning.
Methodology. The basis of the research is formed by the methods of studying and analyzing scientific publications that study aspects of the problem under study, summarizing one’s own experience in the use of digital educational technologies in the educational process, as well as systematizing the studied information.
Results. The possibilities of digital educational technologies in the educational process are described as a way of organizing a digital educational environment. It was revealed that digital educational technologies in close connection with digital educational resources in the educational process give the educational process dynamism, activating mental, cognitive, communicative and educational functions in the classroom.
Practical implications. The results obtained can be applied in the didactics of higher and secondary schools.
Technical Note—Risk Sensitivity and Firm Power: Price Competition with Mean2-Variance Profit Objective Under Multinomial Logit Demand
Authors: Li Hongmin , Webster Scott 
Published: December 2023

Risk Sensitivity and Firm Power: Price Competition with Mean2-Variance Profit Objective Under Multinomial Logit Demand Firms with varying degrees of risk sensitivity perceive the same stochastic profit prospect differently. It is important to understand the equilibrium pricing behaviors under risk aversion and their implications on firms’ survival and market health. The authors identify a power index, which is the ratio of product attractiveness to risk sensitivity, and show that the set of profitable firms is power index ordered. Firms with a favorable power index value earn a positive profit in a price competition, and others are driven to zero profit. Interestingly, although high risk aversion handicaps a firm, this paper shows that moderate risk aversion may give a firm an advantage over an otherwise equivalent competitor that is less risk sensitive. The authors also establish that in an equilibrium with market entry and exit, the power index is generalized to the ratio of product attractiveness and an entry cost-adjusted risk sensitivity measure.
Improving Hotels’ Operational Efficiency Through ESG Investment: A Risk Management Perspective
Authors: Chung Kyunghwa , Nguyen Lan Thi Mai , Nguyen Dung Thi Thuy 
Published: December 2023

Though environment-social-governance (ESG) practices are increasingly prevalent in the business world, academic research about the impact of ESG on firms’ efficiency remains in its infancy. In this study sampling 24 international hotel firms during the period of 2013–2019, we examine how ESG standards improve these hotels’ operational efficiency obtained via data envelopment analysis (DEA). We further investigate how ESG can help manage a crisis by examining the period before and after the COVID-19 pandemic. Our results reveal that ESG can indeed enhance hotels’ efficiency. Specifically, the social and environmental aspects are the most important factors that contribute to the operational efficiency of hotel firms. In the context of the COVID-19 pandemic, hotel firms with the best ESG practice can be more efficient than others, especially those that have very high environmental and social scores. Overall, our findings suggest that hotel firms should consider ESG investment, not only as an effective and sustainable strategy during normal times but also as a crisis management strategy to overcome unexpected crises that may arise in the future. Funding: This work was supported by the Seed fund of Vin University [Grant IO 400043].
Initiations of safer supply hydromorphone increased during the COVID-19 pandemic in Ontario: An interrupted time series analysis
Authors: Young Samantha , Gomes Tara , Kolla Gillian , McCormack Daniel , Dodd Zoë , Raboud Janet , Bayoumi Ahmed M. 
Published: December 2023

Aims
Calls to prescribe safer supply hydromorphone (SSHM) as an alternative to the toxic drug supply increased during the COVID-19 pandemic but it is unknown whether prescribing behaviour was altered. We aimed to evaluate how the number of new SSHM dispensations changed during the pandemic in Ontario.

Methods
We conducted a retrospective interrupted time-series analysis using provincial administrative databases. We counted new SSHM dispensations in successive 28-day periods from March 22, 2016 to August 30, 2021. We used segmented Poisson regression methods to test for both a change in level and trend of new dispensations before and after March 17, 2020, the date Ontario’s pandemic-related emergency was declared. We adjusted the models to account for seasonality and assessed for over-dispersion and residual autocorrelation. We used counterfactual analysis methods to estimate the number of new dispensations attributable to the pandemic.

Results
We identified 1489 new SSHM dispensations during the study period (434 [mean of 8 per 28-day period] before and 1055 [mean of 56 per 28-day period] during the pandemic). Median age of individuals initiating SSHM was 40 (interquartile interval 33–48) with 61.7% (N = 919) male sex. Before the pandemic, there was a small trend of increased prescribing (incidence rate ratio [IRR] per period 1.002; 95% confidence interval [95CI] 1.001–1.002; p<0.001), with a change in level (immediate increase) at the pandemic date (relative increase in IRR 1.674; 95CI 1.206–2.322; p = 0.002). The trend during the pandemic was not statistically significant (relative increase in IRR 1.000; 95CI 1.000–1.001; p = 0.251). We estimated 511 (95CI 327–695) new dispensations would not have occurred without the pandemic.

Conclusion
The pandemic led to an abrupt increase in SSHM prescribing in Ontario, although the rate of increase was similar before and during the pandemic. The absolute number of individuals who accessed SSHM remained low throughout the pandemic.
ZORUNLU KARŞILIK ORANLARINDAKİ UYGULAMA DEĞİŞİKLİĞİNİN BIST BANKA ENDEKSİ ÜZERİNDEKİ ETKİSİNİN ANALİZİ
Authors: KANDEMİR Şenol , SANLI Elif 
Published: December 2023

Bu çalışmada Türkiye Cumhuriyet Merkez Bankası (TCMB)’ nın 23.04.2022 tarihinde yapılan 2022-24 sayılı duyurusu ile zorunlu karşılıkların bankaların bilançolarının pasif tarafına uygulanan zorunlu karşılıkların aktif tarafına da uygulanmaya başlanmasının BIST Banka Endeksinde yer alan bankaların pay fiyatlarına etkisi olay çalışması yöntemiyle analiz edilmiştir.
Pay fiyatlarının 23 Nisan 2022 tarihli zorunlu karşılık uygulamalarında meydana gelen değişime tepkisini ölçmek için ortalama anormal getirileri (AAR), t-test istatistikler ve p-değerleri hesaplanmıştır. Çalışma sonucu zorunlu karşılık uygulamasında meydana gelen değişim duyurusunun BIST banka paylarında anormal getirilere neden olduğu ve piyasanın yarı güçlü formda etkin olmadığını göstermektedir.
On the monotonic properties and oscillatory behavior of solutions of neutral differential equations
Authors: Masood Fahd , Moaaz Osama , Santra Shyam S. , Fernandez-Gamiz Unai , El-Metwally Hamdy 
Published: December 2023

Abstract
In this work, we study new asymptotic properties of positive solutions of the even-order neutral differential equation with the noncanonical operator. The new properties are iterative, which means they can be used several times. We also use these properties to obtain new criteria for oscillation of the studied equation.
Obstetric pulmonary embolism and long-term cardiovascular symptoms: a cross-sectional study in Western Mexico
Authors: Corona Gutierrez America Aime , Rosas Gomez Elvira Sarahi Michelle , Camarena Pulido Eva Elizabet , Lopez Aceves Luis Javier , Robledo Aceves Mireya , Bañuelos Avila Ana Jaqueline 
Published: December 2023

Abstract

Objectives
Pulmonary embolism (PE) is an important cause of maternal mortality. There are several guidelines for its diagnosis and management, but there is little information regarding follow-up and frequency of long-term complications. The aim of the study was to determine the frequency of long-term cardiovascular symptoms in patients who had obstetric PE.

Methods
Cross-sectional study including patients who had PE during pregnancy or the puerperium. A telephone interview was conducted at least one year after PE, to determine the frequency of cardiovascular symptoms, general health, and COVID-19 infection, considering the study was conducted during the 2020 pandemic.

Results
In five years (2015–2019) there were eleven patients with PE, two died during the acute phase, and the rest (nine) were alive and able to answer our interview. Cardiovascular symptoms were common (6, 67 %), the most frequent were fatigue, edema, and mild dyspnea. Four patients (44 %) had slight limitation of physical activity and one (11 %) had PE recurrence. Of the six symptomatic patients four had obesity and one was overweight.

Conclusions
There is a high frequency of long-term cardiovascular symptoms in patients who had PE during pregnancy or the puerperium. Stronger evidence is needed to design a long-term care pathway after obstetric PE.
Cuteness modulates size sound symbolism at its extremes
Authors: Schmitz Dominic , Cicek Defne , Nguyen Anh Kim , Rottleb Daniel 
Published: December 2023

Abstract
Despite the rapidly growing body of research on sound symbolism, one issue that remains understudied is whether different types of sensory information interact in their sound symbolic effects. The experimental study reported here consisted of two tasks and focused on one such potential interaction: size associations and cuteness. First, a forced-choice task was conducted in which size ratings were elicited for pseudowords containing different vowels and consonants. The pseudowords were introduced as names of alien creatures, which were used as visual stimuli in the experiment. Second, the cuteness of alien creatures was assessed in a judgement task. Both tasks were completed by the same group of German speakers. In line with previous research, /aː/ was associated with largeness and /iː/ was associated with smallness. Further, we found that cuteness modulates size associations in /aː/ and /iː/. For /aː/ judged size increased, while for /iː/ judged size decreased with increasing cuteness. Regarding consonants, we found that /ʁ/ evoked higher size associations than other consonants under investigation. Interactions of cuteness and consonants did not reach significance. Our findings call for the integration of other possible factors and features that might show sound symbolic effects or interactions with such in sound symbolism research.
Decision support system for the classification of Downey cells as a pre-diagnostic tool
Authors: Ardicoglu Akisin Yasemin , Akar Nejat , Burkay Cotelı Mert 
Published: December 2023

Abstract

Objectives
Epstein–Barr virus (EBV) is a member of the herpes virus that causes infectious mononucleosis (IM). Downey cell is the atypical lymphocyte of IM and can be seen in various conditions. Peripheral blood smear (PBS) microscopic evaluation is used to identify Downey cells. A lack of experienced professionals or professional errors may obstruct early and accurate diagnostics for the microscopic evaluation. The main objective of this study is to create a decision support system by digitizing the PBS samples. A general tool providing an inexpensive and measurable solution is envisioned to analyze the PBS samples in detail to give alerting flags to prevent missing Downey cells in manual analysis.

Methods
The PBS dataset collected was split into Downey positives and negatives. The negative set consisted of 5 leucocyte subtypes. Mantiscope, a cloud-based slide scanner system, was used to collect images from the physical PBS samples. Clinically and laboratory-confirmed 35 IM patients and 124 healthy PBS slides were selected for this procedure. A number of cell counts were obtained after the application of annotation and augmentation methods, and a partially balanced dataset was created for the artificial intelligence (AI) network training. The verification steps included the calculation of sensitivity, specificity, and Cohen’s kappa metrics from the partitioned testing set that was not used during training. A validation process was also performed over the manually identified PBS samples to measure whether the algorithm noticed the samples or not.

Results
After testing this setup, we have observed 98 % sensitivity and 99 % specificity for Downey cells. According to the validation procedure of Downey positive and negative samples that were carried out by the physicians, a sensitivity of 57 %, specificity of 100 %, and Cohen’s kappa value of 0.5 were observed. Besides, the accuracy was found to be 66 % according to the physicians’ evaluations employing the digital images which were identified by Mantiscope,

Conclusions
Decision support systems can alert the physician for Downey cells and increase the rate of true diagnosis in PBS evaluation. A higher sensitivity and specificity for the detection of Downey cells would be achieved. However, the variance over the dataset is a constraint for effective diagnosis. As the annotation and AI development process continues to collect more data from patients, the model can be updated for future releases.
Œnotourisme in Switzerland-Producer initiatives and policies
Authors: Inoue Takako 
Published: December 2023

Abstract
According to the International Organisation of Vine and Wine (OIV), Switzerland’s wine production in 2021 was 1 million hl, ranking 21st in the world. The Swiss wine production is supported by 2148 communes, where four languages are spoken (German, French, Italian and Romansh), and the vineyards, varying in altitude from 200 to 1150 m, where traditional wines characteristic of the local culture are produced. This paper discusses Œnotourisme (wine tourism) from a policy perspective, which in Switzerland, has become increasingly active in recent years. The paper considers sustainable agriculture and tourism from a policy perspective, examining the origins of the livelihood of agriculture and tourism, starting with landscape studies, and from the viewpoints of the grape and wine producers who operate Œnotourisme. The effects of the policy will be examined. Situating sustainability as it core. Wine tourism is referred to as Œnotourisme, the starting point of wine in this paper.
Do German winegrowers see a connection between biodiversity and wine tourism?
Authors: Tafel Maximilian , Szolnoki Gergely , Jedicke Eckhard 
Published: December 2023

Abstract
German winegrowers are increasingly creating habitats in wine landscapes that are necessary for the preservation of biodiversity. Since biodiversity in the landscape can have a positive impact on tourism attractiveness, one might assume that winemakers are also promoting tourism by doing so, but are they aware of this? The aim of this study is to explore whether German winegrowers see a link between biodiversity and tourism in wine regions and what this link might look like. For this purpose, 52 qualitative interviews were conducted with German winegrowers from all 13 German wine regions. The results show that German winemakers are aware of the central importance of the landscape in attracting tourists and that the clear majority of the interviewed winegrowers believe that a biodiverse landscape has a positive impact on tourism in wine regions. This work reveals unanswered research questions and opens a wide field for researchers to address the topic. Promoting biodiversity could be one of the most important factors contributing to the appeal of wine landscapes and could thus increase the attractiveness of wine regions for potential visitors. Ultimately, tourism flows could be optimized and the predominantly rural German wine regions could preserve their cultural heritage and develop into new aspects of sustainability.
Tip 1 diyabetli ergenlerin beslenme ve egzersiz davranışlarının değerlendirilmesi
Authors: GÜLER Selver , YAVAŞ ÇELİK Melike , ÖZTÜRK ÇOPUR Ebru 
Published: December 2023

Amaç: Tip 1 diyabeti olan ergenlerin hastalığına uyumunun yanı sıra uygun beslenmeleri, planlı ve düzenli fiziksel aktivite yapmaları son derece önemlidir. Çalışmanın amacı, tip 1 diyabetli ergenlerde beslenme ve egzersiz davranışlarının değerlendirilmesidir.
Yöntem: Tanımlayıcı olarak yürütülen araştırmanın örneklemini tip 1 diyabet hastası 101 ergen oluşturuldu. Araştırmanın verileri “Kişisel Bilgi Formu ve Beslenme-Egzersiz Davranış Ölçeği” kullanılarak yüz yüze görüşme yöntemi ile toplandı. Verilerin değerlendirilmesinde tanımlayıcı istatistikler ve bağımsız değişkenin karşılaştırılmasında t testi analizleri kullanıldı. Anlamlılık p