bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipidomics and biodistribution of extracellular vesicles‐secreted by hepatocytes from Zucker lean and fatty rats
Authors: Azparren‐Angulo Maria , Mleczko Justyna , Alboniga Oihane E. , Kruglik Sergei , Guigner Jean‐Michel , Gonzalez Esperanza , Garcia‐Vallicrosa Clara , Llop Jordi , Simó Cristina , Alonso Cristina , Iruarrizaga Marta , Royo Felix , Falcon‐Perez Juan M. 
Published: February 2024

AbstractExtracellular vesicles (EVs) have been involved in metabolic syndrome, although their specific role in the development of the pathology is still unknown. To further study the role of EVs, we have analysed by Raman tweezers microspectroscopy and mass spectrometry‐based lipidomics the small EVs population secreted by fatty (ZF) and lean (ZL) hepatocytes obtained from Zucker rats. We have also explored in vivo and ex vivo biodistribution of these EVs through fluorine‐18‐radiolabelling using a positron emission tomography imaging. Based on the proportion of proteins to lipids and the types of lipids, our results indicate that within the range of small EVs, primary hepatocytes secrete different subpopulations of particles. These differences were observed in the enrichment of triglyceride species in EVs secreted by ZF hepatocytes. Biodistribution experiments showed accumulation in the brain, heart, lungs, kidney and specially in bladder after intravenous administration. In summary, we show that EVs released by a fatty hepatocytes carry a different lipid signature compared to their lean counterpart. Biodistribution experiment has shown no difference in the distribution of EVs secreted by ZF and ZL hepatocytes but has given us a first view of possible target organs for these particles. Our results might open a door to both pathology studies and therapeutic interventions.
Using point‐of‐care devices to examine covariation among blood nutritional‐physiological parameters and their relationships with poxvirus infection, habitat urbanization, and male plumage coloration in house finches (Haemorhous mexicanus)
Authors: McGraw Kevin J. , de Souza Penha Victor Aguiar 
Published: February 2024

AbstractThe development of inexpensive and portable point‐of‐care devices for measuring nutritional physiological parameters from blood (e.g., glucose, ketones) has accelerated our understanding and assessment of real‐time variation in human health, but these have infrequently been tested or implemented in wild animals, especially in relation to other key biological or fitness‐related traits. Here we used point‐of‐care devices to measure blood levels of glucose, ketones, uric acid, and triglycerides in free‐ranging house finches (Haemorhous mexicanus)—a common songbird in North America that has been well‐studied in the context of urbanization, nutrition, health, and sexual selection—during winter and examined (1) repeatability of these methods for evaluating blood levels in these wild passerines, (2) intercorrelations among these measurements within individuals, (3) how blood nutritional‐physiology metrics related to a bird's body condition, habitat of origin (urban vs. suburban), poxvirus infection, and sex; and (4) if the expression of male sexually selected plumage coloration was linked to any of the nutritional‐physiological metrics. All blood‐nutritional parameters were repeatable. Also, there was significant positive covariation between concentrations of circulating triglycerides and glucose and triglycerides and uric acid. Urban finches had higher blood glucose concentrations than suburban finches, and pox‐infected individuals had lower blood triglyceride concentrations than uninfected ones. Last, redder males had higher blood glucose, but lower uric acid levels. These results demonstrate that point‐of‐care devices can be useful, inexpensive ways of measuring real‐time variation in the nutritional physiology of wild birds.
Collagenous gastritis with elevated fecal calprotectin in a pediatric patient
Authors: Rodriguez Natalie , Kumar Soma , Mo Jun , Hartmann Phillipp 
Published: February 2024

AbstractCollagenous gastritis is a rare and chronic inflammatory condition of undetermined etiology characterized histologically by thickened subepithelial collagen bands and increased intraepithelial lymphocytes. Here, we present a collagenous gastritis case in a 16‐year‐old female with chronic abdominal pain, persistently elevated fecal calprotectin (507 and 796 mcg/g), and resolved iron deficiency anemia. The patient's history, laboratory tests, endoscopy, and magnetic resonance imaging ruled out common causes of elevated fecal calprotectin, including Helicobacter pylori and gastrointestinal infections, medications, celiac disease, and inflammatory bowel disease, as well as less common causes such as collagenous colitis. Esophagogastroduodenoscopy revealed significant antral nodularity. Gastric biopsies showed thickened subepithelial collagen band and surface epithelium damage with increased intraepithelial lymphocytes. The ileocolonoscopy was normal. This is among the first reported cases of collagenous gastritis with elevated fecal calprotectin levels that could solely be attributed to this condition.
Formulation of hesperidin‐loaded in situ gel for ocular drug delivery: a comprehensive study
Authors: Gözcü Sefa , Polat Heybet Kerem , Gültekin Yakup , Ünal Sedat , Karakuyu Nasıf Fatih , Şafak Esra Köngül , Doğan Osman , Pezik Esra , Haydar Muhammet Kerim , Aytekin Eren , Kurt Nihat , Laçin Burak Batuhan 
Published: February 2024

AbstractBACKGROUNDAllergic conjunctivitis is one of the most common eye disorders. Different drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus sinensis L. (Rutaceae) fruit peels, with known anti‐inflammatory activity but low solubility. It was complexed with cyclodextrin and encapsulated in situ gel to extend its duration in the eye.RESULTSThe optimized formulation comprised 1% hesperidin, 1.5% hydroxyethyl cellulose, and 16% poloxamer 407. The viscosity at 25 °C was 492 ± 82 cP, and at 35 °C it was 8875 ± 248 cP, the pH was 7.01 ± 0.03, gelation temperature was 34 ± 1.3 °C, and gelation time was 33 ± 1.2 s. There was a 66% in vitro release in the initial 2 h, with a burst effect. A lipoxygenase (LOX) inhibition test determined that hesperidin was active at high doses on leukotyrens seen in the body in allergic diseases. In cell‐culture studies, the hesperidin cyclodextrin complex loaded in situ gel, BRN9‐CD (poloxamer 16%, hydroxy ethyl cellulose (HEC) 1.5%), enhanced cell viability in comparison with the hesperidin solution. It was determined that BRN9‐CD did not cause any irritation in the ocular tissues in the Draize test.CONCLUSIONThe findings of this study demonstrate the potential of the in situ gel formulation of hesperidin in terms of ease of application and residence time on the ocular surface. Due to its notable LOX inhibition activity and positive outcomes in the in vivo Draize test, it appears promising for incorporation into pharmaceutical formulations. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
MXene‐CeO2@PDA Synergistically Enhanced Anticorrosion of Waterborne Epoxy Coating
Authors: Liu Cansen , Chen Qingmei , Cai Canhai , Xu Jianyu 
Published: February 2024

AbstractDeveloping ecofriendly anticorrosion coating has great demand for marine protection. Incorporation of nontoxic inorganic fillers into waterborne epoxy (WEP) coating shows tremendous potential for enhancing corrosion resistance. However, the application of MXene/WEP coating is limited by the poor dispersion of MXene in WEP and insufficient corrosion resistance. Herein, a polydopamine (PDA) modified MXene‐CeO2@PDA (MCP) filler is constructed by a combination of CeO2 with MXene and embedded into WEP to form ecofriendly anticorrosion MCP/WEP coating. Dispersion of MXene in WEP is improved by the introduction of CeO2 and PDA modification. Benefiting from the synergy of the physical labyrinth effect of MXene and the chemical inhibition effect of CeO2, MCP/WEP coating exhibits remarkable anticorrosion behavior in 3.5 wt% NaCl solution with a low corrosion rate (CR) of 4.48 × 10−6 mpy, which is three orders of magnitude lower than that of blank WEP (4.78 × 10−3 mpy). Moreover, MCP/WEP presents long‐term and stable corrosion protection for over 30 days. The results reveal the incorporation of MCP significantly promotes the anticorrosion performance of WEP.
RETRACTED: Discovering Intrinsic Magnetism of Silk Fibroins
Authors: Ranade Varun , Choudhary Ram J. , Singh Kamal P. 
Published: February 2024

AbstractSilk fibroin (SF) is an interesting biomaterials with intriguing mechanical, optical, piezoelectric, and biocompatible properties. The present study reports the first magnetic experiments to show that organic radicals in the building blocks of SF induce permanent magnetization in these materials. A saturation magnetization of 2.8 × 10−3 emu g−1 and non‐zero remnant magnetization of 2.2 × 10−4 emu g−1 with a coercive field of 65 Oe is observed in multiple SFs. Tightly bound β‐sheets of polyglycine‐alanine motifs provides sufficient steric hinderance to organic radicals and protects them from attack of reactive species. Moreover, it also shows that silk's ferromagnetic character can be enhanced by simple mechanical stretching and heating. This work demonstrates a new paradigm of magnetic proteins and opens a route toward the biomimetic discovery of iron‐free magnetic proteins.
Third‐party logistics firm's technology investment and financing options in platform‐based supply chain with 4PL service
Authors: Bi Gongbing , Shen Fuli , Xu Yang 
Published: February 2024

AbstractIn practice, capital‐constrained third‐party logistics (3PL) firms usually obtain bank financing (BF) to invest in logistics technology to enhance the consumer shopping experience. The emergence of financial innovation has prompted the adoption of alternative financing modes by 3PLs, including e‐commerce platform financing (EPF) and fourth‐party logistics financing (4PF). To clarify the differences among the three financing modes at the operational management level, we develop a Stackelberg game model to capture the strategic interactions between the 3PL and creditors. We examine a platform‐based supply chain where a manufacturer sells products through an e‐commerce platform to consumers, with the logistics services for the supply chain provided by the 3PL and fourth‐party logistics (4PL) firms. The analysis results reveal that the equilibrium interest rates under EPF and 4PF share a similar pattern regarding the logistics service cost coefficient, the commission rate, and the 4PL service fee. The difference is that under EPF (4PF), the logistics service level increases in the commission rate (4PL service fee) but decreases under the other financing strategy. Furthermore, the 3PL is inclined to invest in logistics technology only when the fixed investment cost is low, and these financing modes are complementary rather than alternative. The 3PL and manufacturer can benefit from 4PF (BF) when the logistics service cost coefficient is large and the market size is small (large); otherwise, EPF can enhance their profits. We also find that when the opportunity costs of capital are homogeneous, both the 4PL and the platform are consistently willing to act as financiers themselves. However, when considering heterogeneity in the opportunity costs of capital, they may be reluctant to provide financing. Each financing mode may achieve Pareto improvements under specific conditions. Finally, we also analyze the impact of technology R&D risks and endogenous 4PL service fee, yielding some valuable insights.
Thin and high conductive multi‐walled carbon nanotubes/polydimethylsiloxane composite film prepared via solvent method as strain sensors
Authors: Fu Shaoge , Wang Yu , Zhong Yifan , Deng Jia , Zhang Zhenbang , Zhao Haili , Chen Tao 
Published: February 2024

AbstractFlexible strain sensors based on conductive fillers and flexible polymers possessed significant advantages in human motion detection. Preparing a strain sensing layer with high electrical conductivity and excellent mechanical property under high content of conductive filler contributed to the stability of flexible strain sensors. In this study, MWCNTs/PDMS composite film was prepared by the organic solvent method. The microstructure, electrical conductivity, mechanical property, and piezoresistive characteristics of the composite film at different MWCNTs contents were characterized and discussed. When the mass fraction of MWCNTs in the composite film was 5%, the composite film exhibited a high electrical conductivity of 9.56 S/m while maintaining ideal mechanical properties, and the film thickness was just about 180 μm. The relationship between electrical signals and film strain was performed. The piezoresistive characteristic results demonstrated that the prepared composite film could be used as flexible strain sensor for human motion detection. The prepared thin MWCNTs/PDMS composite film in this paper illustrated high conductive and desired flexibility, and was an alternative material for human motion detection.
Synergistic effect of activated carbon from disposed plastics and polybenzoxazine composite coating on corrosion inhibition
Authors: Malathi Devi Sundaramoorthy , Madhavan Durairajan , Jeyasubramanian Kadarkaraithangam , Vimalraj Ayyappan , Gnanadhas Sobhin Osannal Hikku 
Published: February 2024

AbstractThe fabrication of activated carbon dispersed polybenzoxazine (BXP) composite through a single step melt condensation technique is reported. Employing green strategy, activated carbon (AC) was obtained from various types of worn‐out plastics such as computer keyboard, sponge, electrical switches, and automobile tyres. Structural features of all the polymeric composites were explored using Fourier transform infrared (FTIR) spectroscopy, Field Emission Scanning Electron Microscope (FESEM) with Energy Dispersive X‐ray Analysis (EDAX). Thermal stability and hardness of the composites was analyzed by recording thermogravimetric analysis (TGA) and Rockwell hardness measurements. The results of thermal studies revealed that AC–BXP composites show higher thermal stability (301.98°C) than BXP (220.71°C). Rockwell hardness study (RHN) for ACWCKB@BXP is 71 whereas pristine BXP showed only 20. The corrosion protection ability of coated steel was examined through potentiodynamic polarization and electrochemical impedance spectroscopy analysis. From the Tafel plot, more shift in Ecorr value (from −0.6286 to −0.5065 V) towards positive side confirms its corrosion protection ability. Furthermore, the Icorr, the corrosion rate and the corrosion protection efficiency of the ACWTYR@BXP composite are 0.83 × 10−6 A/cm2, 0.0098 mm/year, and 99.54%, respectively, which inhibit the rate of corrosion to a greater extent in 3.5% NaCl solution. The current study applies principles of green chemistry like minimum number of synthesis steps, non‐usage of solvents and simply adoptable coating procedure.
Theoretical study on the kinetics and reaction mechanism involved in the reduction of quinone by 1‐benzyl‐1,4‐dihydronicotinamide
Authors: Medina Manuel E. , Jiménez‐Vazquez Hugo A. , Zepeda‐Vallejo Luis G. , Trigos Ángel 
Published: February 2024

AbstractAlthough it is well known that coenzyme NAD(P)H is involved in anabolic and catabolic reactions in the living organism, there is still significant controversy over the reaction mechanism involved in this biochemical transformation. Thus, 1‐benzyl‐1,4‐dihydronicotinamide was used as a NAD(P)H model in the reduction reaction of 1,4‐benzoquinone (Q), 2,3,5,6‐tetrachloro‐1,4‐benzoquinone, and 2,3‐dicyano‐1,4‐benzoquinone in acetonitrile medium. The kinetic calculations support that formal hydride transfer is the main mechanism promoting Q reduction, while the two‐step process dominates 2,3‐dicyano‐1,4‐benzoquinone reduction. Interestingly, only the single‐electron transfer mechanism takes place when 2,3,5,6‐tetrachloro‐1,4‐benzoquinone is used, affording the corresponding semiquinone derivative as the main product. This mechanistic behavior is related to the presence or absence of electron‐withdrawing groups in the quinones used. Furthermore, the kinetic study results showed that calculated reaction rate constants are in close agreement with experimental results. The results support that formal hydride transfer on the reduction reaction of Q by 1‐benzyl‐1,4‐dihydronicotinamide in acetonitrile proceeds through a hydrogen coupled electron transfer mechanism. This theoretical analysis provides valuable knowledge that can be extrapolated to study the reduction of quinones performed by NADH and NADPH in physiological media.
In Situ Transmission Electron Microscopy Methods for Lithium‐Ion Batteries
Authors: Ji Pengxiang , Lei Xincheng , Su Dong 
Published: February 2024

AbstractIn situ Transmission Electron Microscopy (TEM) stands as an invaluable instrument for the real‐time examination of the structural changes in materials. It features ultrahigh spatial resolution and powerful analytical capability, making it significantly versatile across diverse fields. Particularly in the realm of Lithium‐Ion Batteries (LIBs), in situ TEM is extensively utilized for real‐time analysis of phase transitions, degradation mechanisms, and the lithiation process during charging and discharging. This review aims to provide an overview of the latest advancements in in situ TEM applications for LIBs. Additionally, it compares the suitability and effectiveness of two techniques: the open cell technique and the liquid cell technique. The technical aspects of both the open cell and liquid cell techniques are introduced, followed by a comparison of their applications in cathodes, anodes, solid electrolyte interphase (SEI) formation, and lithium dendrite growth in LIBs. Lastly, the review concludes by stimulating discussions on possible future research trajectories that hold potential to expedite the progression of battery technology.
Subtle 2D/2D MXene‐Based Heterostructures for High‐Performance Electrocatalytic Water Splitting
Authors: Wang Jiaqi , Yang Ganceng , Jiao Yanqing , Yan Haijing , Fu Honggang 
Published: February 2024

AbstractDeveloping efficient electrocatalysts is significant for the commercial application of electrocatalytic water splitting. 2D materials have presented great prospects in electrocatalysis for their high surface‐to‐volume ratio and tunable electronic properties. Particularly, MXene emerges as one of the most promising candidates for electrocatalysts, exhibiting unique advantages of hydrophilicity, outstanding conductivity, and exceptional stability. However, it suffers from lacking catalytic active sites, poor oxidation resistance, and easy stacking, leading to a significant suppression of the catalytic performance. Combining MXene with other 2D materials is an effective way to tackle the aforementioned drawbacks. In this review, the focus is on the accurate synthesis of 2D/2D MXene‐based catalysts toward electrocatalytic water splitting. First, the mechanisms of electrocatalytic water splitting and the relative properties and preparation methods of MXenes are introduced to offer the basis for accurate synthesis of 2D/2D MXene‐based catalysts. Then, the accurate synthesis methods for various categories of 2D/2D MXene‐based catalysts, such as wet‐chemical, phase‐transformation, electrodeposition, etc., are systematically elaborated. Furthermore, in‐depth investigations are conducted into the internal interactions and structure‐performance relationship of 2D/2D MXene‐based catalysts. Finally, the current challenges and future opportunities are proposed for the development of 2D/2D MXene‐based catalysts, aiming to enlighten these promising nanomaterials for electrocatalytic water splitting.
Solution Sequential Deposition Pseudo‐Planar Heterojunction: An Efficient Strategy for State‐of‐Art Organic Solar Cells
Authors: Liu Jiangang , Zhang Yutong , Liu Xingpeng , Wen Liangquan , Wan Longjing , Song Chunpeng , Xin Jingming , Liang Qiuju 
Published: February 2024

AbstractOrganic solar cells (OSCs) are considered as a promising new generation of clean energy. Bulk heterojunction (BHJ) structure has been widely employed in the active layer of efficient OSCs. However, precise regulation of morphology in BHJ is still challenging due to the competitive coupling between crystallization and phase separation. Recently, a novel pseudo‐planar heterojunction (PPHJ) structure, prepared through solution sequential deposition, has attracted much attention. It is an easy‐to‐prepare structure in which the phase separation structures, interfaces, and molecular packing can be separately controlled. Employing PPHJ structure, the properties of OSCs, such as power conversion efficiency, stability, transparency, flexibility, and so on, are usually better than its BHJ counterpart. Hence, a comprehensive understanding of the film‐forming process, morphology control, and device performance of PPHJ structure should be considered. In terms of the representative works about PPHJ, this review first introduces the fabrication process of active layers based on PPHJ structure. Second, the widely applied morphology control methods in PPHJ structure are summarized. Then, the influences of PPHJ structure on device performance and other property are reviewed, which largely expand its application. Finally, a brief prospect and development tendency of PPHJ devices are discussed with the consideration of their challenges.
Movies on Ice: An ArtSci Perspective on Communicating Antarctic Ice in the Climate Emergency
Authors: Stevens Craig , O’Connor Gabby 
Published: February 2024

AbstractIn order to minimise future harm there is urgency in how our societies must respond to the accelerating climate emergency. Despite clear evidence of a changing planet, the response across the socio-political spectrum is varied and certainly not fast enough. The future of the polar ice caps is a highly visible theme in this evidence-response path, both in terms of climate mechanics and in the public’s awareness of ‘climate science’. Much of this public understanding comes through media and often via images and video which the viewer connects with what they have as a mental context. With future climate extremes being beyond our present experience, fictional movies provide a connection. Here we describe an art-science collaboration built around Antarctic ice-ocean field research viewed through the lens of watching movies in Polar field camps. The movies relate to life in camp and at home, climate extremes and planetary futures. The research produces results ranging from data and research papers on the environmental physics, through to climate-informed art viewed by the public in exhibitions as well as collaborative activity with the young people who face the growing challenges of a changing planet.
Model Development
Authors: Kulesza Alexander , Loewe Axel , Stenti Andrea , Nicolò Chiara , Morales-Orcajo Enrique , Courcelles Eulalie , Sips Fianne , Pappalardo Francesco , Russo Giulia , Horner Marc , Viceconti Marco , De Cunha Maluf-Burgman Martha , Lesage Raphaëlle , Kreuzer Steve 
Published: February 2024

AbstractGood Simulation Practice implies that a computational model considered for a simulation task has also been developed according to good practice.