bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental experience with an ocular genetic counseling services in Saudi Arabia
Authors: Alizary Areej , Ahmad Khabir , Al Bakri Amani 
Published: January 2024

Abstract

PURPOSE:
This study reports parental attitudes towards preimplantation genetic diagnosis (PGD) and their satisfaction with genetic counseling services offered by a territory eye care hospital in Saudi Arabia.

METHODS:
This was a cross-sectional study of 30 parents (either father or mother) of children affected by recessive genetic ocular disorders. Their basic knowledge of recessive genetic disorders, attitude toward PGD, and satisfaction with counseling services were assessed using structured telephonic interviews.

RESULTS:
Eighty percent of the participants understood the concept of recessive inheritance patterns and the effect of consanguineous marriages on raising the likelihood of giving birth to a child with genetic disorders. Forty-seven percent of parents understood the risk of having an affected future offspring. Sixty-seven percent of them mentioned that they would consider using preventive measures when conceiving next time. Seventy-three percent of participants stated that they would share the genetic test results with family members. Ninety percent of the parents were satisfied with the genetic counselor’s ability to listen to them and the way the counselor explained the genetic information. There was a statistically significant association between parental willingness to share genetic test results with relatives and being given the opportunity to share information with their genetic counselor (P = 0.01). There was no association between the parental’s knowledge and their willingness to consider using preventative measures in the next pregnancy.

CONCLUSION:
Most parents had a basic understanding of recessive disease. However, they often struggled to comprehend the science and mathematical probabilities determining the recurrence risk in future pregnancies. This complexity makes it difficult for them to recall the information. Attitude toward PGD did not seem to be related with parent knowledge. A significant proportion of the parents expressed willingness to share their genetic test results with relatives, but some were hesitant due to fears of stigma. Most parents were satisfied with genetic counseling services.
The prevalence of pseudoexfoliation syndrome in King Hamad University Hospital
Authors: Rajmohan Archchana , Rahimi Parastou , Nusef Aysha , Ahmed Aysha , Mian Muhammad A. 
Published: January 2024

Abstract

PURPOSE:
The aim of this study is to determine the prevalence of pseudoexfoliation syndrome in patients with cataracts in King Hamad University Hospital (KHUH) and rates of complication in pseudoexfoliation (PXF) patients postoperatively and 2-year follow-up.

METHODS:
A retrospective analysis was conducted on medical records of PXF patients who underwent phacoemulsification and extracapsular cataract extraction in KHUH, Bahrain, between August 31, 2016, and December 30, 2018.

RESULTS:
From the 458 cases analyzed, there were 17 patients with PXF (3.71%). One patient per-operatively experienced posterior capsular repture (5.88%). Zero patients experienced complication in 2 years of follow-up.

CONCLUSION:
This is the first study investigating the prevalence rate of PXF in Bahrain and rates of complication for PXF patients undergoing cataract surgery. This study contributes to further understanding the epidemiology of this disease and its racial variation, for PXF patients to better understand the rate of risks involved in cataract surgery, and for surgeons to create appropriate surgical plans that help reduce the risk of complications commonly seen in these patients.
Sanggenon C ameliorates chronic stress induced depressive behaviors
Authors: Qin Yuxi , Zheng Jing , Jiang Leiming 
Published: January 2024

Purpose: To investigate the effect of Sanggenon C on depression caused by chronic unpredictable mild stress (CUMS) in Wistar rats.
Methods: The anti-depression effect of Sanggenon C was assessed using a forced swimming test and sucrose preference assay. Open-field test was performed to measure CUMS-induced locomotor alteration while histological analyses of the hippocampus and cortex were performed using hematoxylin and eosin (H & E) stains. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was employed to evaluate apoptosis. In addition, expressions of Bax, Bcl-2, cleaved caspase-3, LC3, Beclin, P62 and brain-derived neurotrophic factor (BDNF), as well as phosphorylation level of AMP-activated protein kinase (AMPK) were evaluated by Western blot.
Results: Sanggenon C significantly elevated sucrose preference, reduced immobility time in the forced swimming test, and enlarged squares crossed and rearing times in open-field CUMS rats (p < 0.05). Sanggenon C ameliorated nuclear shrinkage and damage in the hippocampus or cortex. Sanggenon C also regulated the expression of apoptosis-related proteins (Bax, Bcl-2 and cleaved caspase-3), as well as autophagy-associated molecules (LC3, Beclin and p62). Furthermore, Sanggenon C enhanced the expression of BDNF and phosphorylation of AMPK.
Conclusion: Sanggenon C inhibits apoptosis, induces neuronal autophagy, and improves depressive behavior and neuroprotection via activation of AMPK pathway in CUMS rats. However, further research is needed to fully understand the clinical significance of Sanggenon C-mediated AMPK activation in different cellular contexts as potential drug targets.
Efficacy of modified Park’s technique in the treatment of children with strabismus
Authors: Li Yibao , Zhang Rui , Lu Min , Su Yu 
Published: January 2024

Purpose: To investigate the efficacy of modified Park’s technique in children with strabismus.
Methods: A total of 120 patients were recruited in the Department of Ophthalmology, Anhui Provincial Children's Hospital, Anhui, China between January 2019 and December 2021. The patients were divided into study and control groups comprising 60 patients each. Control group underwent rectus muscle adjustment suture using standard incision, while study group received modified Park’s technique, which involved intermuscular membrane incision and conjunctiva two-layer suture method. Various parameters such as perioperative indicators, tear film function, and patient satisfaction were assessed.
Results: The study group had significantly lower intraoperative blood loss, duration of surgery and length of hospital stay (p < 0.01). Also, it showed significantly higher Schirmer’s time, tear film break-up time (TFBUT) time and significantly lower corneal staining score (p < 0.01). Satisfaction level was significantly higher in the study group compared to control group (p < 0.05). So also was clinical efficacy (91.67 %) compared to control group (83.33 %). Furthermore, study group exhibited significantly lower incidence of complications (5) compared to control group (11; p < 0.05).
Conclusion: Enhanced Park’s technique improves perioperative indicators, tear film function, and satisfaction level; it also produces high efficacy and lower incidence of complications. This suggests that it might be a viable substitute for conventional treatment of children with exotropia. However, long-term follow-up data will be required to establish the superiority of this treatment strategy.
Effect of the combination of respiratory care with bronchodilators on pulmonary function, psychological well being, and health behaviors in COPD patients
Authors: Zhang Qundan , Wang Juan , Lu Shuangping 
Published: January 2024

Purpose: To investigate the effect of combining respiratory care with bronchodilators on pulmonary function, psychological well-being, and health behavior in patients with Chronic Obstructive Pulmonary Disease (COPD).
Method: A retrospective analysis was conducted with 90 COPD patients treated in the First People's Hospital of Fuyang, Hangzhou, China between January 2021 and January 2023. Patients were divided into budegopher group (26 patients), symbicor group (28 patients), and combination group (36 patients treated with budegopher plus respiratory care). Lung function, psychological state (Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS), Health Behavior Scale (HPL), and any observed adverse reactions among these groups were recorded.
Results: Significant differences were observed in lung function such as forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC) among the three groups after treatment. Symbicor group showed superior results compared to budegopher group while combination group showed better improvement than budegopher group, and symbicor group (p < 0.001). Pairwise comparisons of psychological state (SAS and SDS) and health behavior (HPL) revealed variations among groups. Lung function parameters (FEV1, FVC) had negative correlations with negative psychological attitudes (SAS, SDS) and moderate positive correlations with health-promoting behaviors (HPL). Negative psychological attitudes (SAS, SDS) were moderately and negatively correlated with health-promoting behaviors (HPL).
Conclusion: Combining respiratory care with bronchodilators demonstrates notable potential to enhance pulmonary function, alleviate negative psychological states, promote healthful behaviors, and expedite the recovery process for COPD patients. However, subtle variations in the therapeutic effects of different drugs may exist, warranting further investigation.
MARCH9, a potential target for the treatment of acute pancreatitis, inhibits NLRP3 inflammasome mediated pyroptosis
Authors: Jin Yuzhou , Ma Na , Lin Min , Huang Jin 
Published: January 2024

Purpose: To investigate the regulatory mechanism of membrane associated ring-CH-type finger 9 (MARCH9) in acute pancreatitis (AP).
Methods: Fifteen AP patients admitted in Changzhou Second People's Hospital Nanjing, China and fifteen healthy individuals participated in this study. MARCH9 expression in serum samples taken from the subjects was assayed. To establish an AP cell model, rat pancreatic acinar (PA) cells were induced with ceruletide and then transfected with MARCH9 overexpression vector. The MARCH9 level and molecular structure, which are related to pyroptosis and inflammatory cytokines, were determined. Cell survival rate and caspase 1 activity was assessed.
Results: MARCH9 was lowly expressed in AP patients’ serum and in ceruletide-induced PA cells. Overexpression of MARCH9 enhanced the survival rate of ceruletide-induced PA cells and reduced the levels of inflammatory cytokines and molecules associated with pyroptosis. MARCH9 overexpression led to a decrease in caspase 1 activity in ceruletide-induced PA cells. Additionally, the overexpression of MARCH9 had a negative regulatory effect on the levels of IL6, p-STAT3/STAT3 and p-JAK2/JAK2 in PA cells induced by ceruletide.
Conclusion: Overexpression of MARCH9 suppresses NLRP3-induced pyroptosis in PA cells through the regulation of IL6/JAK/STAT3 pathway, thus offerimg insights for the potential management of AP.
Combining Runmu fengye tang preparation with hydroxysugar glycolic acid eye drops regulates Th17/Treg balance to treat dry eyes via inhibition of JAK2/STAT3 pathway
Authors: Wen Zhonghua , Li Shulin , Tian Jia , Wang Wei , Zheng Liu , Tao Ping 
Published: January 2024

Purpose: To determine effective therapies for the prevention and clinical treatment of dry eye.
Methods: A scopolamine-induced dry eye rabbit model was administrated with Runmu Fengliang tang (RMFS) and hypromellose 2910, dextran 70 and glycerol eye drops (HGA). Schirmer's I test (SIt), break-up time (BUT) and histopathologic examinations (H&E) were used to assess dry eye symptoms and lacrimal gland damage. Flow cytometry was used to determine the number of apoptotic cells and percentages of Th17 and Treg, while Western blot assay was used to evaluate the expression of proteins related to JAK2/STAT3 pathway.
Results: The combination of RMFS with HGA significantly increased tear secretion (p < 0.001), shortened tear break-up time (p < 0.001), repaired ocular surface damage and reduced apoptosis (p < 0.05) in the scopolamine-induced dry eye model in rabbits, compared with the single-administration group. In addition, it regulated the Th17/Treg-related cytokine balance and inhibited the JAK2/SATA3 pathway.
Conclusion: The combination of RMFS and HGA alleviate dry eye symptoms by inhibiting the JAK2/SATA3 pathway in model rabbits induced by scopolamine and this treatment could be a potential therapeutic strategy for the treatment of dry eye disease. Future studies should focus on clinical data collection to investigate the efficacy and safety of the combination.
Guerra oculta – Operação Kantokeun
Authors: Pitillo João Claudio Platenik 
Published: January 2024

“Guerra Oculta” traduz bem a visão com a qual o Ocidental, principalmente com o advento da Guerra Fria, tratou as hostilidades envolvendo a União Soviética e o Império do Japão entra 1937 a 1945. Durante tal período dois grandiosos exércitos testaram o que havia de mais moderno em equipamento e estratégias. Lutaram na terra, céu e na água, exerceram uma diplomacia vigorosa e constituíram um dos momentos mais importantes da Segunda Guerra Mundial e seus conflitos prévios, no Extremo Oriente, somente após a derrota do Japão envolveria os Estados Unidos e o Reino Unido. A derrotada japonesa em 1939 para os soviéticos obrigou o governo de Tóquio a lutar no Oceano Pacífico desviando o foco anterior do Imperialismo/Militarismo japonês, ocasionando o fatídico ataque à Pearl Harbor. As operações soviéticas que evitaram que o Japão penetrasse na Mongólia e na URSS e freasse as suas ações na China, são até hoje largamente desconhecida, favorecendo uma visão de contenção do imperialismo japonês somente por parte de Washington. Podemos, a partir da análise do conflito levar luz a uma série de eventos centrais que orientaram os imperialismos fascistas nos anos de 1930 e 1940.
Kadar Kolesterol dan Nilai Nutrisi Bakso Daging Sapi Bali dengan Penambahan Tepung Rebung
Authors: Nurfaida Nurfaida , Khaeruddin Khaeruddin 
Published: January 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh penambahan berbagai level tepung rebung terhadap kadar kolesterol dan kandungan nutrisi bakso daging sapi Bali. Rancangan yang digunakan pada penelitian ini adalah rancangan acak lengkap (RAL) pola faktorial dengan 3 kali ulangan. Faktor pertama yaitu level tepung rebung (0%, 10% dan 20%) dan faktor kedua yaitu lama penyimpanan bakso (0, 7 dan 14 hari). Parameter yang diamati yaitu kadar kolesterol, kalium, protein, lemak dan serat kasar. Hasil penelitian menunjukkan bahwa level tepung rebung berpengaruh nyata terhadap kadar kolesterol, kalium, protein, lemak dan serat kasar bakso. Sedangkan lama penyimpanan berpengaruh nyata terhadap kadar kalium, protein, lemak dan serat kasar bakso. Kadar kolesterol terendah (330.26 mg/100 g bakso) terdapat pada perlakuan 20% tepung rebung. Penambahan level tepung rebung meningkatkan kadar kalium, protein, serat kasar dan menurunkan kadar lemak pada bakso. Semakin lama penyimpanan menyebabkan peningkatan kadar kalium dan serat kasar serta penurunan kadar protein.
Implikasi Pendidikan Islam Perspektif Ahmad Dahlan dalam Pembentukan Karakter pada Era Globalisasi
Authors: Sabrina Jihan Abyaz Nadia , S H. Arbai’yah Y , Aryanti Linda Dwi , Yusuf Najwa Anbiya Putri 
Published: January 2024

Artikel ini meninjau mengenai implikasi pendidikan islam berdasarkan gagasan pemikiran K.H. Ahmad Dahlan mengenai pembentukan karakter pada era globalisasi. Metode yang digunakan dalam mengumpulkan data yaitu melalui studi literature. Data dalam artikel ini diperoleh melalui literature berupa jurnal online, buku, dan sumber online lainnya. Hasil pembahasan menunjukan bahwa Pendidikan Islam dalam era globalisasi di Indonesia menurut pemikiran KH. Ahmad Dahlan yaitu pendidikan adalah sebagai salah satu variable penting atau utama dalam meningkatkan karakter kritis dan bebas, serta toleran. Tujuan artikel ini adalah untuk mengetahui bagaimana implikasi atau keterlibatan K.H. Ahmad Dahlan dalam mengemukakan pemikirannya terhadap pendidikan islam serta karakter peserta didik pada era globalisasi. Usaha-usaha yang dijalankan beliau dalam membentuk karakter peserta didik melewati pendidikan islam adalah dengan mengajarkan sikap hidup toleran, karena beliau ingin mengurangi atau bahkan menghindari konflik sosial dan politik yang bersumber atas kehidupan keagamaan. Pendidikan islam sangat berpengaruh pada pembentukan karakter. Karena sejatinya Pendidikan islam ada bertujuan menciptakan karakter manusia supaya menjadi umat yang baik dan beradab
Orthodox identification of the Russian population in the Republic of Dagestan. 1985–1999
Authors: Khalidova О. В. 
Published: January 2024

We have a research idea to show the peculiarities of the development of the Orthodox component in the transitional period of the historical development of our country on the example of the Russian population of the Republic of Dagestan as adherents of Orthodox traditions in the national multiconfessional region. The relevance of the research associated with the transformation of the religious component of Russian people of Dagestan under the influence of globalization and socio-cultural processes of recent decades.A positive effect on the development of the religious component of our society as a whole with a number of features in national regions, in particular, Dagestan have been analyzed. The investigated archival and periodical material and analysis of the empirical data have made it possible to consider the development Orthodox identification in the period 1985–1997. The low growth has been noted. Conclusions have been drawn about the unstable situation of Orthodox parishes due to a number of factors, including the political situation, migration processes among the Russian population, which, in turn, led to the low activity of the clergy, their interaction with the authorities to solve pressing social problems.
Theoretical analysis of the definition of «Creative Pedagogy»
Authors: Ivashchenko Т. А. , Dvoynikovaon.ru Е. S. 
Published: January 2024

In modern society knowledge of Creative Pedagogy ensures high potential of educational activities and achievement of a high level of education quality. The education system is faced with the task of qualitatively preparing a modern graduate for further education and work. Solving this problem requires the search and implementation of new teaching methods, which are a meaningful component of Creative Pedagogy. Scientific works do not fully present a comprehensive analysis of Creative Pedagogy. They primarily reveal only some aspects related to the creativity of a teacher and the principles of organizing a creative environment. The weak theoretical development of the issue under consideration allowed us to formulate the following research problem: what are the essential characteristics of Creative Pedagogy? The purpose of the article is to substantiate theoretical approaches to the definition of “Creative Pedagogy”. Solving the stated goal required the use of theoretical research methods (analysis of scientific literature, synthesis of existing knowledge on the problem under study, generalization). The empirical basis of the study is represented by analytical materials and information resources on the Internet.The results of the research include 1) the concept of “Creative Pedagogy” is considered as an innovative direction of the new education paradigm; 2) the potential of Creative Pedagogy in educational activities has been revealed; 3) the pedagogical conditions for the creative orientation of pedagogical activity have been determined; 4) the basic principles of creating a creative educational environment have been outlined.Key findings: The study extends pedagogical theory toward understanding the content of Creative Pedagogy; the presented basic principles can be used by teachers when organizing a creative educational environment, and the proposed creative teaching methods can be used to stimulate the cognitive activity of students.
Methods for deriving the law of radioactive decay and the law of radiation absorption using the property of the exponent function when studying Physics in the system of secondary vocational education
Authors: Siyukhova D. B. , Demina T. I. 
Published: January 2024

In accordance with the educational standards of the Federal State Educational Standard for Secondary Professional Education, it is intended to familiarize students of professional educational organizations with the properties of radioactive radiation, their practical applications, as well as with some concepts of dosimetry and protection from such radiation.The relevance of this research can be debated for a very long time. But in light of recent events it is obvious.A thorough mastery of all this material is impossible without studying the law of radioactive decay and the law of absorption of radiation.The research problem: the law of radioactive decay and the law of absorption of radiation are expressed using the exponential function N=N_0 e^(-λt) and i=Ie^(-μχ) and are usually not presented in the course of Physics in secondary specialized educational institutions. At best, an appropriate schedule is drawn, but without justification. It seems that this is caused by two reasons: firstly, when writing the exponent function, the base of natural logarithms is used – the number e, which is unknown to intermediate students; secondly, the above laws are usually derived by solving differential equations, which is far beyond the scope of the mathematics curriculum. Meanwhile, both of these difficulties can be easily overcome by using the properties of the exponential function known to students of secondary vocational education.The purpose of the research is to develop a methodology for deriving the law of radioactive decay and the law of radiation absorption, using the properties of the exponential function; to conduct a pedagogical experiment in order to identify the problem of students’ mastery of the proposed material.The research methods used are theoretical justification; calculation; comparison of quantities; graphical analysis of experimental data; generalization of the experimental factors of the study and their explanation.The research results: a methodology has been developed for deriving the law of radioactive decay and the law of radiation absorption using the property of the exponential function; the result of the pedagogical experiment confirmed the effectiveness of the developed methodology.Key conclusions: from the proposed article we can conclude that the presented method for deriving the law of radioactive decay and the law of absorption of radiation using the property of the exponent function can be used by teachers when studying the section «Radioactive Radiation» for both students of professional educational organizations and school students (advanced level).