bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pensar la inter/transdisciplinariedad como un modelo complementario, horizontal e integrador de la segmentariedad del conocimiento
Authors: Beltran Morales Wilson Javier 
Published: January 2024

El presente ensayo hace una revisión de las distintas derivaciones de la disciplinariedad haciendo más énfasis en las metodologías inter/transdiciplinariedad como un modelo de transformación, asociación, vinculación e interacción consciente y creativo de las disciplinas que emerge como una alternativa de solución a los complejos problemas que enfrenta la ciencia hoy en día. Para hablar sobre la fronterizacion de conocimiento es necesario preguntarnos ¿Qué es el límite?, al referirnos a todas aquellas particiones, parcelaciones y segmentaciones que existe, es la representación de una marcación fronteriza de algo, en definitiva, el límite significa no ser superando en ninguna circunstancia. En otras palabras, es el punto ya sea físico o psicológico que no puede ser atravesado, cuando este límite es debatido en las ciencias hay una cierta tensionalidad e incomodidad entre las disciplinas. La inter/transdiciplinariedad no buscar impugna la legitimidad de los saberes disciplinarios a contrario deciden reafirmar sus tradiciones estimulando ciertos gestos de articulación e integración disciplinarias, los estudios inter/transdiciplinarios ha ganado progresivamente terreno en las universidades y el entorno investigativo a ser considerado un eje transversal de sus funciones sustantivas, pero ha perdido su densidad teórica y también su sutileza intelectual al volverse conceptos muy polisémicos en el campo académico y sobre todo practico donde se evidencias pocas estrategias en concreto que propicie esa articulación e integración disciplinar y curricular.
La Educación Nutricional y el Desempeño Académico de los Estudiantes de Ciencias de la Educación de la UJAT
Authors: Vidal Rodríguez Guadalupe del Carmen 
Published: January 2024

La alimentación es un factor importante, tener una buena alimentación ayuda a que el rendimiento del estudiante aumente, mientras que una alimentación deficiente limita los resultados académicos óptimos. Los objetivos principales en esta investigación son: Identificar los hábitos alimenticios de los estudiantes de la UJAT y su relación con el rendimiento académico y analizar las causas externas que coadyuven en el hábito alimenticio del estudiante. La investigación es cuantitativa, con una población de 40 estudiantes de la Lic. en Ciencias de la Educación, se utilizó el método hipotético deductivo y dos variables independientes (alimentación - tiempo y economía del alumno) y una variable dependiente (desempeño académico). En los resultados se resalta que, la mayoría de los estudiantes tienen una mala alimentación, consumen alimentos ricos en grasa, azúcares, lo cual perjudica su rendimiento académico por ende, estos hábitos alimenticios poco saludables limitan su rendimiento, aunque reconocen el tener que mejorar sus hábitos.
Trastornos de Conducta Alimenticia y Estrés en Estudiantes Universitarios
Authors: Burgos Axel García , Azul Urtuzuastegui , Patron Vazquez Luis Alberto 
Published: January 2024

Los Trastornos de Conducta Alimenticia (TCA), son consideradas enfermedades las cuales tienen una gran influencia en la salud de los estudiantes universitarios. Sin embargo, éstos padecimientos, tienen un trasfondo de un origen hereditario y lo más importante el entorno. Ésto sumado, más el entorno y la presión social. Cada vez, es más frecuente la incidencia de los casos de estudiantes con éstas enfermedades. Por lo cual es menester que el estudiante, debe de recibir una atención y seguimiento integral a nivel nutricional, médico y psicológico. Realizar y llevar a cabo programa con la intención, de prevenir y tratar los trastornos de la conducta alimenticia, a su vez, iniciar y realizar una carrera universitaria presenta un riesgo para el desarrollo de estrés y posteriormente problemas emocionales y fisiológicos.
Pseudoquiste Pancreático Secundario a Pancreatitis Aguda con Drenaje Percutáneo como Modalidad de Tratamiento: Reporte de Caso
Authors: Sánchez Servín Cristian Esteban , López Viurquiz Uriel de Jesús , Santos Macedo Gonzalo Nicanor 
Published: January 2024

El pseudoquiste pancreático (PQP) representa una complicación infrecuente pero significativa asociada con la pancreatitis aguda y crónica, así como con traumatismos en el área pancreática. Se caracteriza por la acumulación de líquido dentro o alrededor del páncreas, formando una cavidad con una pared fibrosa. Los PQP pueden ser asintomáticos o manifestarse con dolor abdominal, náuseas, vómitos y pérdida de peso. El tratamiento de los PQP varía según la presentación clínica, el tamaño, la ubicación y la evolución del pseudoquiste. Las opciones terapéuticas incluyen manejo conservador, drenaje percutáneo, endoscópico o quirúrgico. El abordaje ha evolucionado hacia métodos menos invasivos, como el drenaje percutáneo, que ha demostrado ser efectivo en muchos casos. A continuación, presentamos un caso clínico de Pseudoquiste pancreático secundario a pancreatitis aguda, el cual fue resuelto con drenaje percutáneo como modalidad de tratamiento.
Aspectos Fundamentales de los Proyectos Turisticos y Turismo a Pie en Lima Metropolitana, 2023
Authors: Cajavilca Lagos Wilder Oswaldo , Fernández Vega Edinson Antonio , Ghigliño Salazar Judy Giannina Milagros 
Published: January 2024

El presente trabajo de investigación demostró la importancia teórica para definir los aspectos fundamentales de los proyectos turísticos, y también del turismo urbano a pie como una modalidad y alternativa distinta para realizar emprendimientos turísticos por alumnos de la Facultad de Administración de la especialidad de turismo de la Universidad Federico Villarreal, se determinó la correlación entre la variable proyectos turísticos con la variable turismo a pie en Lima Metropolitana, El tipo de investigación fue aplicada, de diseño no experimental, transversal y correlacional, la población y la muestra estuvo conformado por 180 y 123 estudiantes de la especialidad en turismo, Los resultados fueron de 80% de alta correlación entre ambas variables, de una moderada correlación de 53.8% la dimensión factores decisivos con el turismo a pie, de una moderada correlación de 70.8% de la dimensión factores determinantes con el turismo a pie, de una moderada correlación de 77.20% de la dimensión factores deseables con el turismo a pie y de una correlación moderada de 67.4% la dimensión inversión con el turismo a pie en Lima Metropolitana. Concluyéndose que el nivel de significancia p menor a 0,05 determinó que los aspectos fundamentales de proyectos turísticos se relacionan de manera significativa con el turismo a pie en Lima Metropolitana, 2023.
Los Derechos de los animales desde la jurisprudencia de la Corte Constitucional Ecuatoriana
Authors: Zambrano Solorzano Santiago Ramon , Cevallos Erazo Lidia Brigitte , Vargas Rodrigues Patricio Jaime 
Published: January 2024

El presente artículo examina la situación actual de los derechos de la naturaleza en el Ecuador, centrando la discusión en la intersección de los límites entre los derechos de la naturaleza y los derechos de los animales no humanos, posición que se aborda mediante el análisis de los antecedentes históricos y legales de los mismos desde la antigüedad, a través de la doctrina y la jurisprudencia disponible, formulando un artículo de reflexión sobre los dictámenes de la Corte Constitucional de Ecuador acerca de ese tema y como se aborda la protección de la vida animal en la legislación ecuatoriana, centrando la discusión y los resultados en el funcionamiento de la jurisprudencia constitucional como mecanismo de garantías y protección de derechos de los animales no humanos dentro del marco constitucional ecuatoriano que los reconoce dentro de un conjunto sistémico de elementos que componen la naturaleza tomando en cuenta las características propias como forma de entender las relaciones de los animales dentro de los ecosistemas que habitan
Analysis of Risk Factors Affecting the Incident of Hypertension in Bawolato Health Center, Bawolato District, Nias District
Authors: Telaumbanua Arman Budijaya , Amirah Asriwati , Khairatunnisa Khairatunnisa 
Published: January 2024

Based on the 2021 Riskesdas results, the prevalence of the population with high blood pressure is 34.1%. Hypertension data from the Bawolato Community Health Center has increased over the last 2 years, with hypertension cases recorded in 2021 with a total of 842 cases and in 2022 with a total of 1,162 cases. Unhealthy lifestyles, with irregular eating patterns that lead to obesity, smoking, lack of physical activity and consuming too much alcohol, cause blood pressure to increase. The researcher's aim was to determine the risk factors that influence the incidence of hypertension at the Bawolato Community Health Center, Bawolato District, Nias Regency. This type of research is a case control survey. Case Control. The sample consisted of 104 respondents, 52 case groups and 52 control groups taken by consecutive sampling. Data analysis was carried out univariate, bivariate and multivariate using logistic regression tests. The results of the research on bivariate test analysis with chi-square showed that factors influencing the incidence of hypertension were obesity (p= 0.019; OR = 3.080), smoking (p= 0.037; OR= 2.182), physical activity (p= 0.006; OR= 1.875) , alcohol consumption (p= 0.029; OR= 3.407). Meanwhile, the multivariate test found that the factors that had the most influence on the incidence of hypertension were the alcohol consumption variable (p= 0.024; Exp(B)= 4.004) and the obesity variable (p= 0.006; Exp(B)= 3.857). It can be concluded that the risk factors for hypertension at the Bawolato Community Health Center, Bawolato District, Nias Regency are alcohol consumption and obesity. It is recommended that Puskesmas improve promotive and preventive services related to hypertension, educate the younger generation about the dangers of smoking and alcohol consumption, maintain diet, and exercise routine physical activity by utilizing the Health program as a bridge for education and health checks and collaborating with related sectors.
Antihypertensive efficacy and safety of azilsartan medoxomil in patients with diabetes mellitus in real clinical practice. According to the CONSTANT study
Authors: Zhernakova Ju. V. , Chazova I. E. 
Published: January 2024

Background. Obesity and associated diseases are the most common comorbidities in patients with arterial hypertension (AH). The combination of AH and type 2 diabetes mellitus (DM2) significantly exacerbates the cardiovascular risk in this patients. BP control is one of the key components of the multivariate approach to reducing the risk of DM 2 complications. The use of drugs with pronounced antihypertensive properties and at the same time the ability to improve metabolic parameters should be a priority in this category of patients. Assessing the efficacy and safety of azilsartan medoxomil, the last molecule from the ARB class in patients with AH and DM 2 is an urgent task.Purpose. Evaluation of antihypertensive efficacy and safety of azilsartan medoxomil in patients with AH and DM 2 and overweight or obesity.Materials and methods. 235 overweight or obese patients with AH and DM2 enrolled in the international multicenter observational non-interventional prospective study CONSTANT with azilsartan medoxomil according to the approved label. The observation period is 6 months.Results. The dynamics of SBP by visit 4 (6 months) was 29,7±14,5 mmHg, DBP - 13,36±10,9 mmHg (r≤0,001). Overall, the group achieved BP targets in 211 (89.41%) DM patients enrolled in the study. Response to therapy (reduction in SBP by at least 20 mmHg, DBP of 10 mm Hg) was obtained in 177 (75.0%) patients. Glycated hemoglobin (p<0.001) and fasting glucose (p<0.001) significantly decreased in patients with AH and DM. A decrease in total cholesterol, triglycerides, and LDL was observed, including in DM patients not taking statins (p<0.001). Overall, a decrease in waist circumference was observed across the group (p<0.005).Conclusion. Azilsartan medoxomil in real clinical practice proved to be a highly effective antihypertensive drug in patients with AH and DM. The ability of the drug, including in combination with other drugs, to improve the metabolic profile, reduce the volume of adipose tissue makes it a priority drug of choice in patients with AH, obesity and type 2 DM.
Deep Dielectric Breakdown of Silicates: Microstructural Damage and Implications for Lunar Space Weathering
Authors: MacLeod Morgan L. , Sharp Thomas G. , Robinson Mark S. , Jordan Andrew P. 
Published: January 2024

Abstract
Solar energetic particle events electrically charge the lunar surface and may produce electric fields sufficient to induce dielectric breakdown in regolith grains. We irradiated series of silicate minerals with electrons to determine their physical and chemical response to deep dielectric charging and subsequent breakdown. Two electrical phenomena, flashovers and subsurface dielectric breakdown, produced damage including erosional and eruptive channels, surface pits, comminuted grains, and melt and vapor deposits. Iron abundances strongly affected the scale of damage and the minimum fluence required to reach dielectric breakdown; higher iron abundances required higher fluences to reach the breakdown threshold and produced more areally dense damage with each event. If dielectric breakdown is a prominent space-weathering process on the Moon, it should contribute to differential weathering signatures across the lunar surface as a function of target composition.
Effect of the Presence of Pus Cells in Seminal Fluid Samples on Sperm Motility and Morphology in a Group of Males Attended Subfertility Clinics in Galle District, Sri Lanka
Authors: Kadahetti Kaveesha P. , Rodrigo Mahinda , Fernando Lalan H. H. K. 
Published: January 2024

Background: The quality of seminal fluid is one of the main determinants of male fertility. The quality of seminal fluid is determined by several parameters such as volume, sperm concentration, percentage of normal morphology, motility, viability, progressivity, etc. The objective of the study was to assess the effects of the presence of pus cells in seminal fluid samples on normal morphology and motility.
Methods: A cross-sectional study was conducted among a sample of 107 men who attended subfertility clinics in Galle district, Sri Lanka. Consecutive (convenience) sampling method was used. After obtaining the informed consent, semen samples were collected. Pus cell count, sperm motility and normal morphology were evaluated based on the WHO guidelines (2010). Ethical approval was obtained from the Ethics Review Committee, Faculty of Allied Health Sciences, University of Ruhuna.
Results: The majority of samples had pus cell count less than 5 per high power field (n=75, 70.1%). Only 32 (29.9%) had a pus cell count of 5 or above per high power field (/HPF). 32 samples (42.7%) out of 75 samples with pus cell count <5 (/HPF) had a percentage normal morphology of more than 30%, while only 3 samples (9.4%) with pus cell count ≥5 (/HPF) had a percentage normal morphology of more than 30%. The mean and standard deviation (SD) of normal morphology were 26.88% and 8.69% for samples with pus cell count <5 (/HPF) while 21.39% and 7.00% for samples with pus cell count ≥5 (/HPF). Z value was 3.124 and the level of significance was 0.05. Therefore, the finding was highly significant (p= 0.002). 32 samples (42.7%) out of 75 samples with pus cells <5 (/HPF) had normal motility (≥50%). However, only 6 (19%) of 32 samples with pus cells ≥5 (/HPF) had normal motility (≥50%). The mean and standard deviation (SD) of normal motility were 46.32% and 11.30% for samples with pus cell count <5 (/HPF) while the mean and standard deviation (SD) of normal motility were 41.25% and 10.37% for samples with pus cell count ≥5 (/HPF). Z value was 3.124 and the level of significance was 0.05. Therefore the finding was highly significant (p = 0.032).
Conclusions: The obtained results demonstrated that the pus cell count can be a factor inversely associated with sperm morphology and motility.
Advancing Antibody Engineering through Synthetic Evolution and Machine Learning
Authors: Irvine Edward B , Reddy Sai T 
Published: January 2024

Abstract
Abs are versatile molecules with the potential to achieve exceptional binding to target Ags, while also possessing biophysical properties suitable for therapeutic drug development. Protein display and directed evolution systems have transformed synthetic Ab discovery, engineering, and optimization, vastly expanding the number of Ab clones able to be experimentally screened for binding. Moreover, the burgeoning integration of high-throughput screening, deep sequencing, and machine learning has further augmented in vitro Ab optimization, promising to accelerate the design process and massively expand the Ab sequence space interrogated. In this Brief Review, we discuss the experimental and computational tools employed in synthetic Ab engineering and optimization. We also explore the therapeutic challenges posed by developing Abs for infectious diseases, and the prospects for leveraging machine learning–guided protein engineering to prospectively design Abs resistant to viral escape.
Engineering Challenges and Opportunities in Autologous Cellular Cancer Immunotherapy
Authors: Foley Colleen R , Swan Sheridan L , Swartz Melody A 
Published: January 2024

Abstract
The use of a patient’s own immune or tumor cells, manipulated ex vivo, enables Ag- or patient-specific immunotherapy. Despite some clinical successes, there remain significant barriers to efficacy, broad patient population applicability, and safety. Immunotherapies that target specific tumor Ags, such as chimeric Ag receptor T cells and some dendritic cell vaccines, can mount robust immune responses against immunodominant Ags, but evolving tumor heterogeneity and antigenic downregulation can drive resistance. In contrast, whole tumor cell vaccines and tumor lysate-loaded dendritic cell vaccines target the patient’s unique tumor antigenic repertoire without prior neoantigen selection; however, efficacy can be weak when lower-affinity clones dominate the T cell pool. Chimeric Ag receptor T cell and tumor-infiltrating lymphocyte therapies additionally face challenges related to genetic modification, T cell exhaustion, and immunotoxicity. In this review, we highlight some engineering approaches and opportunities to these challenges among four classes of autologous cell therapies.
LEITURAS TERRITORIAIS PARA AÇÃO DA VIGILÂNCIA SOCIOASSISTENCIAL EM TERRITÓRIOS INTERIORANOS
Authors: Zandonade Patricia , Sant’Anna Alessandra de , Zanin Maria , Malta Ferreira Danilo 
Published: January 2024

O artigo discute o processo de apropriação da vigilância socioassistencial por municípios pequenos do norte de Minas Gerais, a partir de uma ação de extensão universitária desenvolvida durante o segundo semestre de 2022. Para isso, o artigo resgata a trajetória da Política Nacional de Assistência Social (PNAS) e a emergência do Sistema Único da Assistência Social (SUAS). Nele a Vigilância Socioassistencial se aproxima das leituras territoriais como linha de base para compreensão das dinâmicas e fluxos que se apresentam no cotidiano das equipes. Neste movimento, o Diagnóstico Socioterritorial ultrapassa a sua função como instrumento para converter-se em eixo estruturante e fundamento para a qualidade, democratização e territorialização, não apenas desta política pública, mas das demais políticas socioassistenciais, ainda que não consolidadas nas ações locais, sobretudo em municípios pequenos e interioranos no Brasil. Neste sentido, o artigo apresenta uma reflexão e sistematização dos conhecimentos desenvolvidos junto às pessoas que participaram da capacitação durante a ação da extensão universitária, bem como destaca alguns resultados dos desafios identificados no desenho, implantação e execução do eixo de Vigilância Socioassistencial nas políticas locais de municípios de pequeno porte. Espera-se que esta identificação possa colaborar para o amadurecimento das políticas locais socioassistenciais brasileiras em contextos interioranos.
NARRATIVA BIOGRÁFICA EM UM ESTUDO DE CASO: IDENTIDADE E CULTURA INDÍGENA NA REGIÃO DO ARAGUAIA – MT
Authors: Negri Costa Eleandra , Philippsen Neusa Inês , Crivelin Jorra Tania Cristina 
Published: January 2024

Este artigo foi elaborado com o propósito inicial de atender a uma das tarefas de avaliação da Disciplina de ‘Sociolinguística’ do programa de Mestrado em Letras (PPGLetras) da Universidade do Estado de Mato Grosso (UNEMAT), localizada no campus de Sinop-MT, durante o primeiro semestre do ano letivo de 2023. O mesmo apresenta um estudo de caso desenvolvido com o objetivo de investigar, à luz da análise da Narrativa Biográfica e da Sociolinguística Interacional, como o sujeito dá significado à sua trajetória de vida e construção identitária. Adota-se uma abordagem qualitativa de pesquisa, e os dados foram gerados por meio de uma entrevista narrativa biográfica, embasada no modelo proposto por Jovivelvik e Bauer (2000). O participante da pesquisa é um indígena da etnia Karajá, que reside na comunidade Lago Grande, às margens do Rio Araguaia, no estado de Mato Grosso. Os resultados foram coconstruídos na dinâmica de interpretação e significação da realidade apresentada pelo participante da pesquisa, em diálogo com Bortoni-Ricardo (2017); Goffman (1981); Bucholtz e Hall (2005); De Fina e Georgakopoulou (2008); Riessman (1993), entre outros autores renomados no campo de estudo. O estudo permitiu compreender como a identidade do indígena é moldada pela trajetória pessoal, pelas relações com comunidades indígenas e pelas mudanças sociolinguísticas influenciadas pelo aculturamento decorrente do processo de migração e colonização na região. Hoje o sujeito se encontra em uma fronteira ideológica de pertencimento, entre se sentir aceito como branco e se sentir indígena.