bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bayesian Approach to Atmospheric Circulation Regime Assignment
Authors: Falkena Swinda K. J. , de Wiljes Jana , Weisheimer Antje , Shepherd Theodore G. 
Published: October 2023

Abstract
The standard approach when studying atmospheric circulation regimes and their dynamics is to use a hard regime assignment, where each atmospheric state is assigned to the regime it is closest to in distance. However, this may not always be the most appropriate approach as the regime assignment may be affected by small deviations in the distance to the regimes due to noise. To mitigate this we develop a sequential probabilistic regime assignment using Bayes’s theorem, which can be applied to previously defined regimes and implemented in real time as new data become available. Bayes’s theorem tells us that the probability of being in a regime given the data can be determined by combining climatological likelihood with prior information. The regime probabilities at time t can be used to inform the prior probabilities at time t + 1, which are then used to sequentially update the regime probabilities. We apply this approach to both reanalysis data and a seasonal hindcast ensemble incorporating knowledge of the transition probabilities between regimes. Furthermore, making use of the signal present within the ensemble to better inform the prior probabilities allows for identifying more pronounced interannual variability. The signal within the interannual variability of wintertime North Atlantic circulation regimes is assessed using both a categorical and regression approach, with the strongest signals found during very strong El Niño years.

Significance Statement
Atmospheric circulation regimes are recurrent and persistent patterns that characterize the atmospheric circulation on time scales of 1–3 weeks. They are relevant for predictability on these time scales as mediators of weather. In this study we propose a novel approach to assigning atmospheric states to six predefined wintertime circulation regimes over the North Atlantic and Europe, which can be applied in real time. This approach introduces a probabilistic, instead of deterministic, regime assignment and uses prior knowledge on the regime dynamics. It allows us to better identify the regime persistence and indicates when a state does not clearly belong to one regime. Making use of an ensemble of model simulations, we can identify more pronounced interannual variability by using the full ensemble to inform prior knowledge on the regimes.
Prognostic impact of monocyte-to-lymphocyte ratio in coronary heart disease: a systematic review and meta-analysis
Authors: Vakhshoori Mehrbod , Nemati Sepehr , Sabouhi Sadeq , Shakarami Mehrnaz , Yavari Behzad , Emami Sayed Ali , Bondariyan Niloofar , Shafie Davood 
Published: October 2023

Objective Inflammatory biomarkers are novel tools to assess the prognosis of different cardiovascular diseases. We evaluated the impact of the monocyte-to-lymphocyte ratio (MLR) on clinical outcomes in patients with coronary heart disease (CHD). Methods We systematically screened English-language articles in PubMed, Scopus, and Web of Science to 31 August 2022. Relevant articles reporting the MLR and its association with clinical outcomes (major adverse cardiovascular events (MACE), coronary artery disease (CAD) severity, mortality, cardiac rupture, subclinical CAD, acute coronary syndrome (ACS) prediction, thin-cap fibroatheroma, no-reflow phenomenon, MLR-related differences in percutaneous coronary intervention, heart failure hospitalization, and depression) in patients with CHD were collected for further analysis. Results Nineteen articles were selected. The mean MLR was 0.34. A higher MLR was significantly associated with an increased risk of MACE among patients with CHD. The MLR was an independent predictor of MACE in patients with ACS. No significant association was found for CAD severity. A complementary analysis was not performed because of few studies focusing on the other predefined endpoints. Conclusions The MLR is a simple and widely available tool to predict MACE in patients with CHD. This biomarker can be utilized in emergency settings to prioritize high-risk patients and optimize therapeutic interventions.
Dual Mini-Fragment Plate Fixation of Midshaft Clavicle Fractures Reduces Risk of Reoperation Compared With Single-Plate Fixation Techniques
Authors: Reddy Rajiv P. , Charles Shaquille , Como Matthew , Chen Stephen R. , Mittwede Peter N. , Rai Ajinkya , Moloney Gele B. , Sabzevari Soheil , Lin Albert 
Published: October 2023

Background: Recent studies have highlighted dual plating as a method of reducing high rates of postoperative complication after operative management of displaced midshaft clavicular fractures. However, few studies have reliably characterized reoperation rates and magnitude of risk reduction achieved when using dual versus anterior and superior single-plate techniques. Hypothesis: There would be lower rates of reoperation among patients who underwent open reduction and internal fixation (ORIF) of displaced midshaft clavicular fractures via dual plating. Study Design: Cohort study; Level of evidence, 3. Methods: This was a retrospective analysis of patients who underwent ORIF for a displaced midshaft clavicular fracture between 2010 and 2021 at a level 1 trauma center with a minimum 12-month follow-up. Patients were separated into 3 cohorts based on fixation type: (1) orthogonal dual mini-fragment plate fixation, (2) superior plate fixation, and (3) anterior plate fixation. Data on patient characteristics, fracture pattern, and reoperations were documented. All-cause reoperation rates and hazard ratio (HR) estimates of dual, superior, and anterior plating were calculated using a multivariate multilevel mixed-effects parametric survival model. Significant confounders including high-risk fracture morphology and smoking status were controlled for in the final model. Results: A final cohort of 256 patients was identified with mean follow-up of 4.9 ± 3.8 years. In total, 101 patients underwent superior plating, 92 underwent anterior plating, and 63 underwent dual plating. Overall, 31 reoperations took place (18 in superior, 12 in anterior, 1 in dual plating) among 22 patients. Major contributors to reoperation included symptomatic hardware (n = 11), nonunion (n = 8), deep infection (n = 7), and wound dehiscence (n = 2). Superior plating revealed the highest reoperation rate of 0.031 per person-years, followed by anterior plating with 0.026 per person-years and dual plating with 0.005 per person-years. Overall, single plating (either anterior or superior placement) had a nearly 8-fold greater risk of reoperation than dual plating (HR, 7.62; 95% CI, 1.02-56.82; P = .048). Further broken down by technique, superior plating had an 8-fold greater risk of reoperation than dual plating (HR, 8.36; 95% CI, 1.10-63.86; P = .041), but anterior plating did not demonstrate a statistically significant difference compared with dual plating (HR, 6.79; 95% CI, 0.87-52.90; P = .068). Conclusion: Dual-plate fixation represents an excellent treatment for displaced midshaft clavicular fractures, with low rates of nonunion and reoperation. When compared with single locked superior or anterior plate fixation, dual mini-fragment plate fixation has a nearly 8-fold lower risk of reoperation.
State investigative interest varies across daily life and predicts academic engagement: Replication and extension of the nomological network
Authors: Roemer Lena , Stoll Gundula , Rounds James , Ziegler Matthias 
Published: October 2023

Recent contributions propose to integrate a state perspective into the conceptualization of vocational interests. Such integration addresses in-the-moment expressions of interests and allows to track relations to distal outcomes of vocational interests more closely. To further the trait-state integration of vocational interests, insights into the nomological network of state vocational interests are necessary. In this preregistered experience sampling study of 217 university students, we studied state investigative interest in daily life and the relations with theory-derived person- and situation-related constructs. Results from 5631 observations across 3.5 weeks showed that specific situation characteristics, openness, happiness, and current social student role were associated with state investigative interest. Furthermore, person-aggregated state investigative interest and the reactivity of investigative interest in situations related with their academic studies predicted individuals’ overall academic engagement in some cases. Generally, the relations in the nomological network were stronger when state investigative interest and hypothesized constructs were more closely aligned. Overall, the results underline the systematic nature and psychological relevance of state vocational interests. We discuss how integrating a state perspective into research on vocational interests implies novel approaches for capitalizing on the power of vocational interests.
Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study
Authors: de Carvalho Jozélio Freire , Brandão Neto Rodrigo A , Skare Thelma Larocca , Shoenfeld Yehuda 
Published: October 2023

Objective To compare clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (PAPS) with and without limb ischemia (LI). Methods A transverse study with 66 (83.3% female) PAPS patients was performed. All data were evaluated. Patients were subdivided into one of two groups: PAPS with LI and PAPS without LI and compared. Results Sixty-six primary APS were selected. PAPS with LI group exhibited a longer disease duration ( p = .012) and more arterial events ( p = .002). A lower frequency of venous events was observed in PAPS with LI ( p = .007), and deep venous thrombosis ( p = .016). Furthermore, PAPS with LI patients had more deficiency of protein C of coagulation ( p = .015) than the others. Conclusion PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.
Influence of Primary Tumor Resection on Survival of Patients With Metastatic Siewert Type II Adenocarcinoma of the Esophagogastric Junction: A Population-Based, Propensity-Matched Analysis
Authors: Chen Jiamin , Jia Xuan , Chen Hanwen , Cai Jianting , Chen Liubo 
Published: October 2023

Objective It remains unclear whether primary tumor resection improves survival in patients with metastatic Siewert type II adenocarcinoma of the esophagogastric junction (AEG). Therefore, our study attempted to investigate the prognostic value of primary tumor resection on metastatic AEG. Methods In total, 4200 patients diagnosed with metastatic AEG were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015. Patients were categorized into two groups according to the performance of primary tumor resection. Pearson’s chi-square test, Kaplan–Meier survival curve, and Cox regression analysis were conducted in this study. In addition, propensity-score matching was conducted to match 323 patients who received primary tumor resection and another 323 patients without. Results Multivariate Cox regression analysis demonstrated that primary tumor resection was a significant prognostic factor in patients with metastatic AEG before matching. Moreover, in the matched cohort, metastatic AEG patients receiving primary tumor resection had significantly longer overall survival (hazard ratio [HR]: .54, 95% confidence interval [CI]: .46–.64, P < .001) and cancer-specific survival (HR: .53, 95% CI: .45–.63, P < .001). Subgroup analysis similarly revealed that primary tumor resection was significantly associated with better survival in most subgroups. Conclusion The present population-based study identified that primary tumor resection led to significantly superior survival in patients with metastatic AEG. These findings are likely to contribute to the development of individualized therapy in metastatic AEG.
Routine use of filtered air as endotamponade in the management of primary rhegmatogenous retinal detachment
Authors: Rapizzi Emilio , Barosco Guido , Zemella Nicola , Samassa Francesco , Rassu Nicolò , Frattolillo Antonio , Buratto Lenni 
Published: October 2023

Purpose To evaluate the safety and efficacy of filtered air as endotamponade in the management of primary rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV) and complete drainage of subretinal fluid. Methods For this retrospective study, we reviewed the medical charts of 273 patients (275 eyes) who consecutively underwent PPV, subretinal fluid drainage and filtered air tamponade to treat primary RRD between 2018 and 2022. As primary outcome we evaluated the anatomical success considered as retinal reattachment after single surgery. As secondary outcomes: final mean best corrected distance visual acuity (BCDVA), complications, and mean intraocular pressure (IOP) trends. Results The anatomical success was reached by 262 (95.6%) of cases. Mean BCDVA improved from 0.73 LogMAR at baseline, to 0.21 LogMAR at the end of follow-up. As complications we recorded: 5 cases of clinically relevant macular pucker, 1 full thickness macular hole, and 1 PFO bubble under the retina. The mean IOP remained on normal values during the overall follow-up period.
Environmental factors’ influence on criminal legal involvement for people with serious mental illness
Authors: Frances Kathryn , Epperson Matt , Payton Briana , Thompson Julian 
Published: October 2023

Summary Efforts to assess the risk of criminal legal system involvement among people with serious mental illness (SMI) often rely on strategies that locate the risk at the individual level. The present study examines environmental factors that contribute to criminal legal involvement for people with SMI in mental health treatment settings. Thirty-one people with serious mental illness and prior criminal legal involvement were interviewed in this qualitative study. Interviews focused on factors that contributed to and protected against criminal legal involvement. The research team engaged in inductive thematic analysis of interview data. Findings Findings reveal that understanding of physical, social, and treatment environments is critical to risk assessment with this population. In highlighting the role of the environment, we offer findings that may lead to improved strategies for service delivery with this population. Complicating contemporary approaches to risk assessment, our findings suggest that mental health treatment systems that serve individuals with serious mental illness should engage in meaningful consideration of environmental factors. Applications Identification of protective and risk factors in clients’ physical, social, and treatment environments is critical for social work practice with individuals who have a history of criminal legal involvement and serious mental illness. Treatment settings can create opportunities for the development of protective factors by integrating wrap-around services, treatment services that follow an empowerment-participation strengths model, and post-incarceration services with clients.
Performance of BeBack Crossing Catheter in Chronic Total Occlusion in Patients With Chronic Limb-Threatening Ischemia: A Single-Center Experience
Authors: Cohen Israel , Raskin Daniel , Barash Yiftach , Silverberg Daniel , Halak Moshe , Khaitovich Boris 
Published: October 2023

Purpose: To describe a single-center experience in the treatment of chronic limb-threatening ischemia (CLTI) with the application of BeBack catheter (Bentley InnoMed, Germany) in patients with arterial chronic total occlusion (CTO). Materials and Methods: A retrospective review of patients who underwent limb revascularizations using the BeBack catheter between 2015 and 2022. All patients had an initial failed attempt using a traditional guidewire and catheter technique. Technical success was considered whenever a successful re-entry or lesion crossing using the study device was achieved. Procedural success was defined as recanalization of the occluded artery with residual stenosis of less than 30%, and improvement in ankle-brachial index (ABI) after 24 hours. A Rutherford score was assigned to each limb and affected anatomical segments and lesion length were documented. Procedural access sites and complications were noted. Results: The study included 72 patients who underwent 78 procedures using the BeBack crossing catheter. Procedural success was achieved in 91% of cases, with a technical success rate of 92.3%. The most frequently involved occluded segments were the femoral and popliteal arteries. The average ABI improved from 0.59 to 0.95 after the procedure. The most used access site was the contralateral femoral, and the BeBack catheter was employed on 85 occasions. Only 1 patient suffered a severe immediate adverse effect, and during the 30-day follow-up period, 2 patients needed reintervention. Unfortunately, 3 patients died during the follow-up period. Conclusion: The BeBack catheter offers a viable option for the treatment of patients with chronic total occlusion, with high procedural success and a low complication rate. Clinical Impact The BeBack catheter presents a notable advancement for clinicians managing chronic limb-threatening ischemia (CLTI) and arterial chronic total occlusion (CTO), showcasing over 90% procedural and technical success rates in this study. Its adept ability to navigate and recanalize occluded segments provides a robust alternative, especially when traditional techniques falter. This innovation may chane clinical strategies in vascular interventions, offering an efficient and reliable option, thereby potentially enhancing patient outcomes in limb revascularizations.
A Ratio Between Infrarenal and Suprarenal Aortic Diameters Corrects for Absolute Aortic Diameter Variations due to Patients’ Sex and Body Size
Authors: Boer Gert Jan , Larbi Nora , Bekken Joost A. , Kuijper Tjallingius M. , Vroegindeweij Dammis , Fioole Bram 
Published: October 2023

Objectives: Aortic diameters may differ significantly between patients with different gender and body size. The aim of this study was to relate absolute aortic diameters to age, sex, height, and weight of the patients and to correct for these factors by calculating the ratio between the infrarenal and the suprarenal aortic diameters. Methods: A total of 458 patients who underwent elective endovascular aneurysm repair (EVAR) between 2004 and 2018 were included. The aortic anatomy in this group of elective EVAR patients was compared with a control group of 75 patients without an abdominal aortic aneurysm (AAA). The aortic diameter was measured at 4 suprarenal points and 4 infrarenal points. Ratios were calculated by dividing the mean infrarenal neck diameter by 4 suprarenal measurements. Results: Patients in the aneurysm group had significantly larger suprarenal and infrarenal aortic diameters. The ratios between the mean infrarenal neck diameter and all 4 suprarenal measurements were larger in the AAA group than in the control group. In both groups, there was a significant correlation between the mean infrarenal neck diameter and sex, height, weight, and body surface area (BSA). However, in both groups, all 4 ratios between the mean infrarenal neck diameter and suprarenal aortic diameters were not correlated with age, sex, height, weight, or BSA, except for the ratio between the mean infrarenal neck diameter and the aortic diameter measurement proximal to the upper renal artery, which was correlated to weight and BSA in the control group. Conclusion: The mean infrarenal neck diameter is correlated with sex, height, weight, and BSA. However, when the suprarenal aortic diameter was used as an internal control for the mean infrarenal neck diameter, we were able to correct for these variations in aortic diameters due to sex and body size. The clinical relevance of this ratio in patients treated by EVAR has yet to be assessed in future research. Clinical Impact In the assessment for EVAR suitability the absolute diameter of the aneurysm neck is taken into account. We believe that using absolute diameters is not the appropriate way to assess this suitability, but that patient characteristics such as age, gender and body size, should be factored into this assessment. In this paper, we show that suprarenal and infrarenal aortic diameters are both significantly increased in patients with an aneurysm compared with patients without an aneurysm. Besides, we found that mean infrarenal aortic diameter is correlated with sex, height, weight, and body surface area. Finally, we propose a new ratio system, using suprarenal diameters as an internal control, to correct for aortic diameter variations due to sex and body size.
Effect of Perioperative Stroke on Survival After Carotid Intervention
Authors: Cambiaghi Tommaso , Mills Alexander , Leonard Samuel , Husman Regina , Zaidi Syed T. , Koh Ezra Y. , Keyhani Kourosh , Wang S. Keisin 
Published: October 2023

Objectives Perioperative stroke is the most dreaded complication of carotid artery interventions and can severely affect patients’ quality of life. This study evaluated the impact of this event on mortality for patients undergoing interventional treatment of carotid artery stenosis with three different modalities. Methods Patients undergoing carotid revascularization at participating Memorial Hermann Health System facilities were captured from 2003-2022. These patients were treated with either carotid endarterectomy (CEA), transfemoral carotid stenting (TF-CAS), or transcarotid artery revascularization (TCAR). Perioperative outcomes, including stroke and mortality, as well as follow-up survival data at 6-month intervals, were analyzed and stratified per treatment modality. Results Of the 1681 carotid revascularization patients identified, 992 underwent CEA (59.0%), 524 underwent TCAR (31.2%), and 165 underwent TF-CAS (9.8%). The incidence of stroke was 2.1% (CEA 2.1%, TCAR 1.7%, and TF-CAS 3.6%; P = .326). The perioperative (30-day) death rate was 2.1% (n = 36). The perioperative death rate was higher in patients who suffered from an intraoperative stroke than in those who did not (8.3% vs 1.9%, P = .007). Perioperative death was also different between CEA, TCAR, and TF-CAS for patients who had an intraoperative stroke (.0% vs 33.3% vs .0%, P = .05). TCAR patients were likely to be older ( P < .001), have a higher body mass index ( P < .001), and have diabetes mellitus ( P < .001). Patients who suffered from an intraoperative stroke were more likely to have a symptomatic carotid lesion (58.3% vs 28.8%, P < .001). The TCAR group had a significantly lower survival at 6 months and 12 months when compared to the other two groups (64.9% vs 100% P = .007). Conclusion Perioperative stroke during carotid interventions significantly impacts early patient survival with otherwise no apparent change in mid-term outcomes at 5 years. This difference appears to be even more significant in patients undergoing TCAR, possibly due to their baseline higher-risk profile and lower functional reserve.