bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calibrating Sales Forecasts in a Pandemic Using Competitive Online Nonparametric Regression
Authors: Simchi-Levi David , Sun Rui , Wu Michelle Xiao , Zhu Ruihao 
Published: November 2023

Motivated by our collaboration with Anheuser-Busch InBev (AB InBev), a consumer packaged goods (CPG) company, we consider the problem of forecasting sales under the coronavirus disease 2019 (COVID-19) pandemic. Our approach combines nonparametric regression, game theory, and pandemic modeling to develop a data-driven competitive online nonparametric regression method. Specifically, the method takes the future COVID-19 case estimates, which can be simulated via the susceptible-infectious-removed (SIR) epidemic model as an input, and outputs the level of calibration for the baseline sales forecast generated by AB InBev. In generating the calibration level, we focus on an online learning setting where our algorithm sequentially predicts the label (i.e., the level of calibration) of a random covariate (i.e., the current number of active cases) given past observations and the generative process (i.e., the SIR epidemic model) of future covariates. To provide robust performance guarantee, we derive our algorithm by minimizing regret, which is the difference between the squared [Formula: see text]-norm associated with labels generated by the algorithm and labels generated by an adversary and the squared [Formula: see text]-norm associated with labels generated by the best isotonic (nondecreasing) function in hindsight and the adversarial labels. We develop a computationally efficient algorithm that attains the minimax-optimal regret over all possible choices of the labels (possibly non-i.i.d. and even adversarial). We demonstrate the performances of our algorithm on both synthetic and AB InBev’s data sets of three different markets (each corresponds to a country) from March 2020 to March 2021. The AB InBev’s numerical experiments show that our method is capable of reducing the forecast error in terms of weighted mean absolute percentage error (WMAPE) and mean squared error (MSE) by more than 37% for the company. This paper was accepted by J. George Shanthikumar, data science. Funding: This work was partially supported by the Massachusetts Institute of Technology Data Science Lab and AB-InBev Corporation. Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2023.4969 .
A zero-agnostic model for copy number evolution in cancer
Authors: Schmidt Henri , Sashittal Palash , Raphael Benjamin J. 
Published: November 2023

Motivation
New low-coverage single-cell DNA sequencing technologies enable the measurement of copy number profiles from thousands of individual cells within tumors. From this data, one can infer the evolutionary history of the tumor by modeling transformations of the genome via copy number aberrations. Copy number aberrations alter multiple adjacent genomic loci, violating the standard phylogenetic assumption that loci evolve independently. Thus, specialized models to infer copy number phylogenies have been introduced. A widely used model is the copy number transformation (CNT) model in which a genome is represented by an integer vector and a copy number aberration is an event that either increases or decreases the number of copies of a contiguous segment of the genome. The CNT distance between a pair of copy number profiles is the minimum number of events required to transform one profile to another. While this distance can be computed efficiently, no efficient algorithm has been developed to find the most parsimonious phylogeny under the CNT model.

Results
We introduce the zero-agnostic copy number transformation (ZCNT) model, a simplification of the CNT model that allows the amplification or deletion of regions with zero copies. We derive a closed form expression for the ZCNT distance between two copy number profiles and show that, unlike the CNT distance, the ZCNT distance forms a metric. We leverage the closed-form expression for the ZCNT distance and an alternative characterization of copy number profiles to derive polynomial time algorithms for two natural relaxations of the small parsimony problem on copy number profiles. While the alteration of zero copy number regions allowed under the ZCNT model is not biologically realistic, we show on both simulated and real datasets that the ZCNT distance is a close approximation to the CNT distance. Extending our polynomial time algorithm for the ZCNT small parsimony problem, we develop an algorithm, Lazac, for solving the large parsimony problem on copy number profiles. We demonstrate that Lazac outperforms existing methods for inferring copy number phylogenies on both simulated and real data.
Individual differences in cooperative and competitive play strategies
Authors: Hauge Theresa C. , Ferris Daniel P. , Seidler Rachael D. 
Published: November 2023

IntroductionCooperation and competition are common in social interactions. It is not clear how individual differences in personality may predict performance strategies under these two contexts. We evaluated whether instructions to play cooperatively and competitively would differentially affect dyads playing a Pong video game. We hypothesized that instructions to play cooperatively would result in lower overall points scored and differences in paddle control kinematics relative to when participants were instructed to play competitively. We also predicted that higher scores in prosociality and Sportspersonship would be related to better performance during cooperative than competitive conditions.MethodsPairs of participants played a Pong video game under cooperative and competitive instructions. During competitive trials, participants were instructed to score more points against one another to win the game. During the cooperative trials, participants were instructed to work together to score as few points against one another as possible. After game play, each participant completed surveys so we could measure their trait prosociality and Sportspersonship.ResultsCondition was a significant predictor of where along the paddle participants hit the ball, which controlled ball exit angles. Specifically, during cooperation participants concentrated ball contacts on the paddle towards the center to produce more consistent rebound angles. We found a significant correlation of Sex and the average points scored by participants during cooperative games, competitive games, and across all trials. Sex was also significantly correlated with paddle kinematics during cooperative games. The overall scores on the prosociality and Sportspersonship surveys were not significantly correlated with the performance outcomes in cooperative and competitive games. The dimension of prosociality assessing empathic concern was significantly correlated with performance outcomes during cooperative video game play.DiscussionNo Sportspersonship survey score was able to predict cooperative or competitive game performance, suggesting that Sportspersonship personality assessments are not reliable predictors of cooperative or competitive behaviors translated to a virtual game setting. Survey items and dimensions probing broader empathic concern may be more effective predictors of cooperative and competitive performance during interactive video game play. Further testing is encouraged to assess the efficacy of prosocial personality traits as predictors of cooperative and competitive video game behavior.
Height, weight, and body mass index in patients with familial dysautonomia
Authors: Cotrina Maria L. , Morgenstein Barr , Perez Miguel , Norcliffe-Kaufmann Lucy , Palma Jose-Alberto , Kaufmann Horacio 
Published: November 2023

Background
Children with familial dysautonomia (FD) are smaller and grow more slowly than the general population. It is unknown whether this abnormal growth is due to comorbidities that patients with FD live with, or if it is a direct effect of the disease-causing homozygous ELP-1 mutations. Here, we created growth curves for weight, height, and body mass index (BMI) in male and female children with FD to monitor the nutritional status of patients with FD.

Methods
We used the New York University (NYU) FD Registry which includes data from 680 individuals with FD who were followed longitudinally since birth. We generated sex-specific FD growth charts for three age ranges (birth to 36 months, 2 to 20 years, and 2 to 40 years) and compared them to the general population. We generated Kaplan-Meier curves to test the hypothesis that FD patients with low BMI had shorter survival than the rest of the cohort.

Results
Growth charts generated from 591 individuals with FD show that these patients grow more slowly, reach less height, and gain less weight than the general population. The impact of FD on height was more pronounced in girls than in boys. However, both groups showed markedly low weights, which resulted in low BMI. Low weight, but not height, is already evident at birth. In a subpopulation of FD patients, we found that treatment with growth hormone or spinal fusion surgery helped patients achieve the expected growth characteristic of FD patients, but these treatments did not lead FD patients to achieve the growth pattern of the general population. Contrary to our hypothesis, low BMI had no impact on patient survival.

Conclusions
Pediatric patients with FD have lower height, weight, and BMI compared to the general pediatric population, but this does not appear to affect survival. Growth curves specific to the FD population are an important tool to monitor growth and nutritional status in pediatric patients with FD when the general population growth curves are of limited use.
Thyroid Metastasis to the Colon
Authors: Lewine Eliza B. , Patel Zinal , Forman Jacqueline , Manvar Amar , Hanna Iman 
Published: November 2023

ABSTRACT
Approximately 1% of colorectal cancers can be attributed to metastatic neoplasms originating from other primary sources typically the lung, ovary, breast, prostate, kidney, or skin. Metastasis to the colon from the thyroid however is exceedingly rare. We present a 76-year-old man with a history of papillary thyroid carcinoma WHO presented with colon polyps consistent with carcinoma from his papillary thyroid carcinoma. The findings in this report suggest prompt colorectal cancer screening after thyroid cancer diagnosis and regular screening thereafter.
The Effect of Halal Certification and Entrepreneurial Marketing on the Successful Small and Medium-sized Enterprises of Food Products
Authors: Hasanah Hibatul , Sarma Ma'mun , Munandar Jono Mintarto 
Published: November 2023

This research aims to examine the effect of halal certification and entrepreneurial marketing on the successful small and medium-sized enterprises (SMEs) of processed food products and investigate the dominant factors affecting the successful business of food products. A quantitative method supported by Structural Equation Modeling Partial Least Square (SEM-PLS) is employed to conduct this research. Seventy-one respondents from SMEs actors of food products registered in the Institute for the Study of Food, Drugs, and Cosmetics of the Indonesian Ulema Council (LPPOM MUI) of Riau Province and had the halal certification became the research sample. They are selected using a purposive sampling technique. This research reveals that halal certification positively affects a successful enterprise, while entrepreneurial marketing, directly and indirectly, positively affect a successful business. In addition, entrepreneurial marketing positively affects halal certification. It interprets that halal certification and entrepreneurial marketing are the significant factors determining the successful enterprise of food products. Furthermore, the dominant factors affecting the successful business of processed food products are the certainty of material quality based on the halal concept and consumer preference (halal certification), the level of ability to weave the relation with government (entrepreneurial marketing), and marketing performance (successful business). So, halal certification and entrepreneurial marketing are the essential factors that have to be considered by entrepreneurs to achieve a successful enterprise of food products.Â Â
Acetate and succinate benefit host muscle energetics as exercise‐associated post‐biotics
Authors: Ismaeel Ahmed , Valentino Taylor R. , Burke Benjamin , Goh Jensen , Saliu Tolulope P. , Albathi Fatmah , Owen Allison , McCarthy John J. , Wen Yuan 
Published: November 2023

AbstractRecently, the gut microbiome has emerged as a potent modulator of exercise‐induced systemic adaptation and appears to be crucial for mediating some of the benefits of exercise. This study builds upon previous evidence establishing a gut microbiome‐skeletal muscle axis, identifying exercise‐induced changes in microbiome composition. Metagenomics sequencing of fecal samples from non‐exercise‐trained controls or exercise‐trained mice was conducted. Biodiversity indices indicated exercise training did not change alpha diversity. However, there were notable differences in beta‐diversity between trained and untrained microbiomes. Exercise significantly increased the level of the bacterial species Muribaculaceae bacterium DSM 103720. Computation simulation of bacterial growth was used to predict metabolites that accumulate under in silico culture of exercise‐responsive bacteria. We identified acetate and succinate as potential gut microbial metabolites that are produced by Muribaculaceae bacterium, which were then administered to mice during a period of mechanical overload‐induced muscle hypertrophy. Although no differences were observed for the overall muscle growth response to succinate or acetate administration during the first 5 days of mechanical overload‐induced hypertrophy, acetate and succinate increased skeletal muscle mitochondrial respiration. When given as post‐biotics, succinate or acetate treatment may improve oxidative metabolism during muscle hypertrophy.
Competing Roles of Aristotle’s Account of the Infinite
Authors: Finley Robby 
Published: November 2023

Abstract
There are two distinct but interrelated questions concerning Aristotle’s account of infinity that have been the subject of recurring debate. The first of these, what I call here the interpretative question, asks for a charitable and internally coherent interpretation of the limited pieces of text where Aristotle outlines his view of the ‘potential’ (and not ‘actual’) infinite. The second, what I call here the philosophical question, asks whether there is a way to make Aristotle’s notion of the potential infinite coherent and rigorous with modern tools that can stand as a rival to the widely-accepted view of the infinite as characterized in a mathematical theory of sets. In this paper, I argue that the theoretical roles that Aristotle intends his account of the potential infinite to fulfill lead to a deep and irresoluble tension that can help explain the persistence of debates on both of these questions. I do so by turning to the places where Aristotle attempts to argue for or against the existence of particular infinite processes to show that he slides between different underlying notions of when changes are possible. Making these underlying notions clear can help us better understand the role of Aristotle’s account in the history of philosophy, the possible pitfalls for a contemporary theory of the potential infinite, and what each of these debates might learn from each other.
An appraisal of the practice of duplicate testing for the detection of irregular analytical errors
Authors: Green Alastair D. , Lee Graham R. 
Published: November 2023

Abstract

Objectives
Our study aimed to determine the usefulness of duplicate testing in identifying irregular analytical errors and subsequent prevention of patient mismanagement.

Methods
In our laboratory, all requests for Na+, Ca2+, alkaline phosphatase (ALP), and high-sensitivity cardiac-troponin-I (hs-cTnI) are run in duplicate. Data from four separate weeks for Na+ (n=21,649), Ca2+ (n=14,803) and ALP (n=19,698); and a full year for hs-cTnI (n=17,036) were gathered. For each test, pre-defined limits for differences between duplicates were used to identify erroneous results (Fliers). We further characterised a subset of such fliers as “critical errors”, where duplicates fell on opposing sides of a reference/decision making threshold. The costs/benefits of running these tests in duplicate were then considered in light of increased number of tests analysed by this approach.

Results
For Na+, 0.03 % of duplicates met our flier defining criteria, and 0.01 % of specimens were considered critical errors. For Ca2+ requests, 4.58 % of results met our flier defining criteria and 0.84 % were critical errors. For ALP, 0.22 % of results were fliers, and 0.01 % were critical errors. For hs-cTnI, 1.58 % of results were classified as fliers, whilst 0.14 % were classified as a critical error. Depending on the test in question, running all analyses in duplicate increased annual costs by as little as €1,100 (for sodium), and as much as €48,000 (for hs-cTnI).

Conclusions
Duplicate testing is effective at identifying and mitigating irregular laboratory errors, and is best suited for assays predisposed to such error, where costs are minimal, and clinical significance of an incorrect result can justify the practice.
Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
Authors: Chang Lixian , Cheng Xuelian , Gao Xingjie , Zou Yao , Yuan Weiping , Zhang Li , Zhu Xiaofan 
Published: November 2023

Abstract
Considering the connection between the Fanconi anemia (FA) signaling pathway and tumor development, we aim to investigate the links between the FA gene expression and the survival prognosis of acute myeloid leukemia (AML) patients. Our study begins by identifying two distinct clusters of pediatric AML patients. Following the batch matching of the TARGET-AML, TCGA-LAML GSE71014, GSE12417, and GSE37642 cohorts, the samples were divided into a training set and an internal validation set. A Lasso regression modeling analysis was performed to identify five signatures: BRIP1, FANCC, FANCL, MAD2L2, and RFWD3. The AML samples were stratified into high- and low-risk groups by evaluating the risk scores. The AML high-risk patients showed a poorer overall survival prognosis. To predict the survival rates, we developed an FA Nomogram incorporating risk score, gender, age, and French–American–British classification. We further utilized the BEAT-AML cohort for the external validation of FA-associated prognostic models and observed good clinical validity. Additionally, we found a correlation between DNA repair, cell cycle, and peroxide-related metabolic events and FA-related high/low risk or cluster 1/2. In summary, our novel FA-associated prognostic models promise to enhance the prediction of pediatric AML prognosis.
Stability in Threshold VAR Models
Authors: Chen Pu , Semmler Willi 
Published: November 2023

Abstract
This paper investigates the stability of threshold autoregressive models. We review recent research on stability issues from both a theoretical and empirical standpoint. We provide a sufficient condition for the stationarity and ergodicity of threshold autoregressive models by applying the concept of joint spectral radius to the switching system. The joint spectral radius criterion offers a generally applicable criterion to determine the stability in a threshold autoregressive model.
The Nameless Daughter of Saul
Authors: Hutton Jeremy M. 
Published: November 2023

Abstract
The roles of Michal and Merab in the received tradition of the Book of Samuel are complex. This study examines the literary embeddedness of Saul’s daughter within several passages in which she appears (1Sam 18:17–19*; 1Sam 19:11–17; 2Sam 3:12–16*; 2Sam 21:8). In many cases, the names of Saul’s daughters—Michal and Merab—can be easily excised without doing significant damage to the surrounding text. This article concludes that some episodes featuring one of Saul’s daughters may originally have assumed only a single, nameless woman.
Job’s Clean Hands: A Proposal for Job 22:30
Authors: Yoo Philip Y. 
Published: November 2023

Abstract
Among Eliphaz’s last words to Job in MT Job 22:30, ’î-nāqî (NJPS: »guilty«) and venimlaṭ bebōr kappêkā (NJPS: »He will be delivered through the cleanness of your hands«) present substantial interpretative challenges. Rather than ending with words of hope or encouragement in his third and final speech, this short article argues that Eliphaz ends his speeches with his most serious allegation against Job.
El trámite para calificar la discapacidad en Chile. Las cargas administrativas que deben asumir las personas con discapacidad en la región del Biobío
Authors: Muñoz Aravena Waleska , Riquelme Parra Susana , Santibáñez Parra Martina 
Published: November 2023

El Estado proporciona distintas prestaciones a las personas, para cuyo cumplimiento se diseñan acciones que les suponen algún tipo de coste según su propia experiencia. Moynihan & Herd identifican este coste como cargas administrativas. Este artículo identifica y analiza las cargas que supone para las personas la calificación de su discapacidad, de acuerdo con lo que Moynihan, Herd & Harvey proponen como costes de aprendizaje, psicológicos y de cumplimiento. A través de una metodología cualitativa, se realizaron entrevistas a personas con discapacidad y funcionarias/os públicas/os vinculados al trámite de calificación en la región del Biobío en Chile. Se observaron problemas de acceso y exclusión, así como el traspaso de la responsabilidad de asumir costos a las personas con discapacidad debido a un enfoque liberal en el diseño de las políticas públicas.
Los retos actuales de la política en América Latina
Authors: Alcántara Sáez Manuel 
Published: November 2023

La política en América Latina se encuentra en una etapa de consolidación democrática en la medida en que el avance de la poliarquía en las últimas tres décadas ha sido irrestricto.Sin embargo, tanto las diferencias entre países que no hacen sino expresar en buen grado el capital político acumulado a lo largo de sus historias como las diferentes respuestas políticas dadas a los distintos desafíos, permiten elaborar análisis sobre el momento actual que vive la región. Por consiguiente este artículo tiene una naturaleza descriptiva y exploratoria acerca de los problemas actuales que invaden a la referida región: por una parte se analiza el estado de la política en América Latina al finalizar 2012 sobre la base del enfoque genérico de los estudios acerca de la calidad de la democracia y, toda vez que dentro de la región existen diferencias muy significativas entre los distintos países que la componen y ello abre la oportunidad de averiguar, al menos a guisa de hipótesis, cuales son los elementos explicativos de esa diferencia, el asunto de los retos conformará la segunda parte de este artículo.Palabras clave: calidad de la democracia, democratización, liderazgo político, carreras políticas, profesionalización de la política.
¿Cómo hacer de la evaluación un instrumento para la profesionalización docente? De las concertaciones políticas a las atribuciones jurídicas en el sector educativo
Authors: Martínez Méndez Juan Ismael 
Published: November 2023

Los actores educativos han redefinido sustantivamente sus responsabilidades evaluativas en instrumentos de mayor jerarquía normativa. Ya sea para el ingreso, la promoción o la permanencia en el magisterio, dichos cambios modifican los mecanismos de toma de decisión en el sistema educativo, por lo que este artículo busca clarificar las implicaciones que tiene esta nueva organización para hacer de las políticas de evaluación un instrumento servible en la profesionalización de los docentes de educación básica de México.Palabras clave: reformas educativas, actores educativos, políticas de evaluación, profesionalización docente, Servicio Profesional Docente