bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica
Authors: Bahadır Semerci Alican , Yıldırım Merve , Oztay Füsun , Sagıroglu Mehmet , Tunç Kenan 
Published: November 2023

AbstractThe fatty acid profile, antioxidant/antibacterial, and cytotoxic effects of the extracts obtained from Jurinea turcica B.Doğan& A.Duran have been evaluated for the first time in the current study. The fatty acid profile of ethanolic extracts was determined using the Soxhlet extractor by a gas chromatography‐mass spectrometer. The antioxidant and antibacterial activities were measured by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and ferrous reduction tests and the disc diffusion technique. Additionally, the cytotoxicity and wound healing assays were performed on A549 cells. The highest amount of component in the leaf extract was docosanoic acid methyl ester, whereas abundant arachidonic acid methyl ester was mainly found in the flower extract. The IC50 values, the 50 % scavenging value for the DPPH radical, were 179.13 and 124.67 μg/mL for the leaf and flower extracts, respectively. IC50 values (the half‐maximal inhibitory concentration) were 10.4 and 24.7 μg/mL for the flower and leaf extracts, respectively. The leaf extract showed more potent antibacterial activity on Enterococcus faecalis (17 mm) and Staphylococcus aureus (16 mm) bacteria than the flower extract. In conclusion, the extracts of J. turcica have anti‐cancerogenic and antibacterial effects. Leaf extracts have antibacterial and anti‐metastatic effects, while flower extracts show antioxidant, cytotoxic, and apoptotic properties in A549 cells.
Utilization of Response Surface Methodology in Electrocoagulation for Process Optimization and Parametric Analysis
Authors: Akhtar Adnan , Suleman Malik Shoaib , Gillani Syed Muzammil Awais , Aslam Zaheer 
Published: November 2023

AbstractElectrocoagulation (EC) is a well‐recognized and feasible treatment technique for wastewater treatment. The process optimization and analysis of process parameters of EC not only aid to scale up the EC process at an industrial level but also help to explore the economic and environmental considerations to achieve higher efficiency. Response surface methodology (RSM) is a prominent chemometric approach for both process optimization and evaluation of different factors for the removal of target pollutants from wastewater. This review provides a thorough examination of notable scholarly works that focus on the use of the RSM in EC for the purpose of wastewater treatment. Furthermore, the current advancements in implementing the RSM approach not only for standalone EC processes but also for the case are described where it is being practiced as a part in the integrating system for wastewater treatment.
Phosphonium Salt/Al‐Porphyrin Copolymer as Bifunctional Heterogeneous Catalyst for CO2 Conversion to Cyclic Carbonates
Authors: Valentino Laura , Célis Chloé , Campisciano Vincenzo , Gruttadauria Michelangelo , Aprile Carmela , Giacalone Francesco 
Published: November 2023

AbstractThe effective chemical valorization of CO2 by means of its conversion into valuable products is now more than ever a topic of considerable interest. It is on that basis that herein we have chosen the conversion of CO2 and epoxides to cyclic carbonates as a convenient route to achieve this goal. A new bifunctional (Lewis acid/nucleophile) heterogeneous material, TSP‐AlCl‐PhospBr, was designed in order to guarantee a close proximity between the two active sites that can cooperate to the activation and opening of the epoxide ring. The prepared copolymer has been extensively characterized using various spectroscopic and analytical techniques. As a heterogeneous catalyst, it enables efficient chemical conversion of CO2 and epoxides, even at low temperatures, down to 30 °C, without the use of solvents. In particular, the catalyst demonstrates high turnover numbers (TON) and frequency values (TOF). Recyclability studies on TSP‐AlCl‐PhospBr have shown its stability and reusability for consecutive cycles without the need of reactivation procedures.
Organic Photothermal Materials Obtained Using Thermally Activated Delayed Fluorescence Design Principles
Authors: Caine Jana R. , Choi Heekyoung , Hojo Ryoga , Hudson Zachary M. 
Published: November 2023

AbstractOrganic small molecules with high photothermal conversion efficiencies that absorb near‐infrared light are desirable for photothermal therapy due to their improved biocompatibility compared to inorganic materials and their ability to absorb light in the biological transparency window (650–1350 nm). Here we report three donor‐acceptor organic materials DM‐ANDI, O‐ANDI, and S‐ANDI that show high photothermal conversion efficiencies of 46–68 % with near‐infrared absorption. The design of these molecules is based on the rational modification of a thermally activated delayed fluorescence material to favour a low photoluminescence quantum yield by reducing HOMO‐LUMO overlap. Encapsulating these materials into either neat nanoparticles or aggregated organic dots modulates their photothermal conversion efficiencies, and also facilitates dispersion in water.
A proposed structural connectivity matrices approach for the superior fronto‐occipital fascicle in the Harvard‐Oxford Atlas comparative framework following the Pandya comparative extrapolation principle
Authors: Makris Nikos , Rushmore Richard , Yeterian Edward 
Published: November 2023

AbstractA key set of connections necessary for the most complex brain functions are the long association cortico‐cortical fiber tracts. These pathways have been described by the Dejerines and others using post mortem histological or brain dissection techniques. Given methodological limitations, these fiber connections have not been delineated completely in humans. Although the stem portions of fiber tracts have been identified in humans, their precise origins and terminations remain to be determined. By contrast, the origins and terminations as well as the stems of long cortico‐cortical association fiber pathways in monkeys have been detailed in the macaque monkey brain using experimental tract tracing methods. Deepak Pandya made major contributions to the delineation of fiber tracts in the monkey brain. In the early 1990s, he compared his observations in monkeys with the original descriptions in humans by the Dejerines. With the advent of diffusion‐weighted imaging, Dr. Pandya extended this line of investigation to the human brain with Dr. Nikos Makris. In this translational analysis of long association cortico‐cortical fiber tracts, they applied a principle of extrapolation from monkey to human. In the present study, we addressed the reasoning and the complex methodology in translating brain structural connectivity from monkey to human in one cortico‐cortical fiber tract, namely the superior fronto‐occipital fascicle, which was delineated in both species by Dr. Pandya and colleagues. Furthermore, we represented this information in the form of connectional matrices in the context of the HOA2.0‐ComPaRe framework, a homological monkey‐to‐human translational system used in neuroimaging.
The role of non‐genomic actions of progesterone and its membrane receptor agonist in ovarian cancer cell death
Authors: Koyanagi Takahiro , Saga Yasushi , Takahashi Yoshifumi , Tamura Kohei , Yoshiba Takahiro , Takahashi Suzuyo , Taneichi Akiyo , Takei Yuji , Mizukami Hiroaki , Fujiwara Hiroyuki 
Published: November 2023

AbstractBackgroundProgesterone therapy is a relatively inexpensive treatment option for endometrial and breast cancers, with few side effects. Two signaling pathways usually mediate the physiological effects of progesterone, namely genomic and non‐genomic actions. Genomic action occurs slowly via the nuclear progesterone receptor (PR), whereas the membrane progesterone receptor (mPR) induces rapid non‐genomic action.AimsWe investigated the effects of progesterone and various PR agonists on ovarian cancer cells.Methods and ResultsPR expression of six serous ovarian cancer cell lines was examined by western blotting, and mPR expression was examined by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR). PR‐negative and mPR‐positive ovarian cancer cells were exposed to progesterone and seven types of PR agonists (medroxyprogesterone acetate [MPA], dehydroepiandrosterone, dienogest, levonorgestrel, drospirenone, pregnenolone, and allopregnanolone) at 10–400 μM, and viable cell counts after exposure for 30 min were measured using the water‐soluble tetrazolium (WST‐1) assay. Ovarian cancer cell lines were exposed to 100 μM progesterone, and the expression of BAX, a pro‐apoptotic protein, after 1–5 min was examined by western blotting.Western blotting detected no PR expression in the six serous ovarian cancer cell lines. In contrast, RT‐qPCR detected mPR expression in all six serous ovarian cancer cell lines. Progesterone and MPA‐induced cell death in all tested ovarian cancer cell lines in a concentration‐dependent manner, whereas no effect was observed for other PR agonists. Western blotting revealed that pro‐apoptotic protein BAX expression occurred 1 min after exposure to progesterone, suggesting that the cytocidal effects are mediated by rapid non‐genomic action.ConclusionProgesterone and MPA exhibited a rapid cytocidal effect on PR‐negative ovarian cancer cells through non‐genomic action. Progesterone and MPA could be novel adjuvant therapies for ovarian cancer.
Retracted: Minimal channel cost‐based energy‐efficient resource allocation algorithm for task offloading under FoG computing environment
Authors: Baskar Premalatha , Periasamy Prakasam 
Published: November 2023

SummaryThe Internet of Things (IoT) and fog computing (FC) can be integrated to manage massive data processing and complex networks. It can improve communication performance and provide robust computation for resource‐constrained IoT devices by deploying more fog nodes (FNs) at the edge/IoT networks. In this article, the optimal energy‐efficient fog resource allocation (oEeFRA) algorithm is proposed with the help of the minimal channel cost resource allocation (MiCCRA) method to ensure the load balancing and task offloading of the IoT‐FoG network under various constraints. Resource blocks (RBs) should be maintained higher than FNs in this proposed model to enhance the task‐offloading processes. The MiCCRA algorithm is proposed to provide a minimum of one FN and RB for each IoT device used in the IoT‐FoG network and also to ensure that weather each FN should be allotted with one or more RBs and IoT devices for efficient task offloading and load balancing activities. The energy efficiency (EE) of the proposed oEeFRA algorithm is computed through the MiCCRA algorithm by varying RB, FN, and IoT devices. The performance analysis shows that the proposed algorithm achieved the maximum EE of 6.12 × 109 bit/J, 3.019 × 1010 bit/J, and 5.69 × 1010 bit/J for varying RBs, FNs, and IoTs.
Simultaneous Incorporation of CsI in the Two‐step Deposition Process Boosts the Power Conversion Efficiency and Stability of Perovskite Solar Cells
Authors: Cheng Nian , Li Weiwei , Zheng Dingshan , Yang Wen‐Xing 
Published: November 2023

AbstractTwo‐step deposition method has been widely exploited to fabricate FA1‐xCsxPbI3 perovskite solar cells. However, in previous studies, CsI is mainly added into the PbI2 precursor with DMF/DMSO as solvent. Here in this study, a novel method to fabricate FA1‐xCsxPbI3 perovskite has been proposed. The CsI is simultaneously added into the PbI2 precursor and the organic FAI/MACl salts solution in our modified two‐step deposition process. The resulting FA1‐xCsxPbI3 film exhibits larger perovskite crystals and suppressed defect density (4.05×1015 cm−3) compared with the reference perovskite film (9.23×1015 cm−3) without CsI. Therefore, the obtained FA1‐xCsxPbI3 perovskite solar cells have demonstrated superior power conversion efficiencies (PCE=21.96 %) together with better long‐term device stability.
Palladium(II) and Platinum(II) Bis(Stibinidene) Complexes with Intramolecular Hydrogen‐Bond Enforced Geometries
Authors: Zechovský Jan , Kertész Erik , Erben Milan , Hejda Martin , Jambor Roman , Růžička Aleš , Benkő Zoltán , Dostál Libor 
Published: November 2023

AbstractThe coordination capability of two N,C,N pincer coordinated stibinidenes, i. e. bis(imino)‐ [2,6‐(DippN=CH)2C6H3]Sb (1) or imino‐amino‐ [2‐(DippN=CH)‐6‐(DippNHCH2)C6H3]Sb (2) toward palladium(II) and platinum(II) centers was examined. In the course of this study, seven new square‐planar bis(stibinidene) complexes were synthesized and characterized by NMR, IR, Raman, UV‐vis spectroscopy and single crystal (sc)‐X‐ray diffraction analysis. In all cases, both stibinidene ligands 1 or 2 adopt trans positions, but differ significantly in the torsion angle describing mutual orientation of aromatic rings of the stibinidenes along the Sb−Pd/Pt−Sb axes. Furthermore, majority of complexes form isomers in solution most probably due to a hindered rotation around Sb−Pd/Pt bonds caused by bulkiness of 1 and 2. This phenomenon also seems to be influenced by the absence/presence of a pendant −CH2NH− group in 1/2 that is able to form intramolecular hydrogen bonds with the adjacent chlorine atom(s) attached to the metal centers. The whole problem was subjected to a theoretical study focusing on the role of hydrogen bonds in structure architecture of the complexes. To describe the UV‐vis spectra of these highly coloured complexes, TD‐DFT calculations were employed. These outline differences between the stibinidene ligands, the transition metals as well as between the charge of the complexes (neutral or anionic).
Integration of T‐cell clonality screening using TRBC‐1 in lymphoma suspect samples by flow cytometry
Authors: Castillo Felipe , Morales Constanza , Spralja Biserka , Díaz‐Schmidt Joaquín , Iruretagoyena Mirentxu , Ernst Daniel 
Published: November 2023

AbstractBackgroundThe diagnosis of T‐cell non‐Hodgkin lymphomas (NHL) is challenging. The development of a monoclonal antibody specific for T‐cell receptor β constant region 1 (TRBC1) provides an alternative to discriminate clonal T cells. The aim of this study was to evaluate the diagnostic potential of an anti‐TRBC1 mAb for the identification of T‐NHL.MethodsWe performed a cross‐sectional diagnostic analytic study of samples tested for lymphoma. All samples sent for lymphoma screening were first evaluated using the standard Euroflow LST, to which a second additional custom‐designed T‐cell clonality assessment tube was added CD45/TRBC1/CD2/CD7/CD4/TCRγδ/CD3. Flow cytometry reports were compared with morphological and molecular tests.ResultsFifty‐nine patient samples were evaluated. Within the T‐cell population, cut‐off percentages in the CD4+ cells were from 29.4 to 54.6% and from 23.9 to 52.1% in CD8+ cells. Cut‐off ratios in CD4+ T cells were from 0.33 to 1.1, and in CD8+ cells between 0.22 and 1.0. Using predefined normal cut‐off values, 18 of 59 (30.5%) samples showed a restricted expression of TRBC1. A final diagnosis of a T‐NHL was confirmed clinically and/or by histopathological studies in 15 of the 18 cases (83.3%). There were no cases of T‐NHL by morphology/IHC with normal TRBC1 expression. Non‐neoplastic patient samples behaved between predefined TRBC1 cut‐off values.ConclusionsExpression of TRBC1 provides a robust method for T‐cell clonality assessment, with very high sensitivity and good correlation with complementary methods. TRBC1 can be integrated into routine lymphoma screening strategies via flow cytometry.
Fire regime shapes butterfly communities through changes in nectar resources in an Australian tropical savanna
Authors: Leone Julia B. , Larson Diane L. , Richards Anna E. , Schatz Jon , Andersen Alan N. 
Published: November 2023

AbstractFire‐dependent savanna provides key habitat for butterflies globally, but we know little about how fire regimes, including fire frequency and season, affect them. These impacts are likely to be primarily indirect, through changes in overall habitat structure, the abundance of larval host plants, and/or the provision of nectar resources for adults. We examined the relationships among fire regime, butterfly abundance and diversity, and vegetation structure and floral resources within a long‐term fire experiment near Darwin in the Australian monsoon tropics. We surveyed butterflies and floral resources throughout the 2019–2020 wet season in three replicate plots of each of six experimental treatments that had been operating for 15 years. All plots subject to fire had been burned in the previous dry season. We observed 24 butterfly species and 280 individuals representing all five butterfly families found in Northern Australia. Butterfly abundance was highest under early dry‐season (June) fire regimes (mean = 11.9 individuals per plot survey) compared with a late dry‐season (October) regime (mean = 6.7) and in the long‐term absence of fire (mean = 5.3), and this was correlated with the abundance of floral resources. The distribution of butterflies was also highly associated with floral resources within plots regardless of fire treatment. Butterfly species richness was significantly higher in early dry‐season (mean = 6.8) compared with unburned (mean = 3.3) plots but did not differ between early and late dry‐season (mean = 4.7) plots. Butterfly and floral diversity were similar across all early dry‐season fire treatments regardless of whether they had been burned every 1, 2, 3, or 5 years. Our finding that early dry‐season burning promotes butterfly diversity and abundance by increasing the supply of nectar resources has important implications for biodiversity management more broadly, given that nectar is a critical resource for many animal taxa.
Sodium‐glucose cotransporter 2 inhibitors are associated with reduced risk of mortality and readmissions in heart failure
Authors: Karlström Patric , Pivodic Aldina , Dahlström Ulf , Fu Michael 
Published: November 2023

AbstractAimsCompelling evidence from randomized trials has shown that sodium‐glucose cotransporter 2 inhibitors (SGLT2is) are effective in heart failure (HF) across the spectrum of left ventricular ejection fractions. However, there are very few studies with real‐world data.Methods and resultsA retrospective cohort analysis was performed based on patient‐level data from the Swedish Heart Failure Registry (SwedeHF) linked with three other national registers. Patients included had an index registration between 3 September 2013 and 31 December 2020 in SwedeHF and were on treatment with guideline‐recommended therapy without or with SGLT2i 3 months before or 6 months after their index registration. Endpoints were mortality or readmissions. Association between the use of SGLT2i and endpoints was studied using adjusted Cox models. In the overall cohort, 796/22 405 patients were included with/without SGLT2i. In patients with SGLT2i, 93.5% had diabetes mellitus. In the overall cohort, SGLT2i was statistically significantly associated with all‐cause mortality {hazard ratio [HR]: 0.61 [95% confidence interval (CI) 0.48–0.79], P < 0.0001}, cardiovascular mortality [HR: 0.29 (95% CI 0.17–0.50), P < 0.0001], cardiovascular mortality or HF readmission [HR: 0.89 (95% CI 0.80–1.00), P = 0.046], and all‐cause readmissions [HR: 0.90 (95% CI 0.81–0.99), P = 0.038]. Similar results were obtained for the diabetes cohort. However, no association with cause‐specific readmissions was observed.ConclusionsThis nationwide real‐world study indicates that patients with HF, in which majority coexisted with diabetes mellitus, who received SGLT2i were statistically significantly associated with lower risk for all‐cause mortality, cardiovascular mortality, cardiovascular mortality or HF readmissions, and all‐cause readmissions, in line with the randomized trials assessing SGLT2i.
Cardiological parameters predict mortality and cardiotoxicity in oncological patients
Authors: Romann Sebastian W. , Finke Daniel , Heckmann Markus B. , Hund Hauke , Giannitsis Evangelos , Katus Hugo A. , Frey Norbert , Lehmann Lorenz H. 
Published: November 2023

AbstractAimsOncological patients suspected at risk for cardiotoxicity are recommended to undergo intensified cardiological surveillance. We investigated the value of cardiac biomarkers and patient‐related risk factors [age, cardiovascular risk factors (CVRFs), and cardiac function] for the prediction of all‐cause mortality (ACM) and the development of cardiotoxicity.Methods and resultsBetween January 2016 and December 2020, patients with oncological diseases admitted to the Cardio‐Oncology Unit at the Heidelberg University Hospital were included. They were evaluated by medical history, physical examination, 12‐lead electrocardiogram, 2D echocardiography, and cardiac biomarkers [high‐sensitivity cardiac troponin T (hs‐cTnT) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP)]. The primary endpoint was defined as ACM and the secondary endpoint was defined as cardiotoxicity, as defined by the European Society of Cardiology. Of the 1971 patients enrolled, the primary endpoint was reached by 490 patients (25.7%) with a median of 363.5 [interquartile range (IQR) 121.8, 522.5] days after presentation. Hs‐cTnT of ≥ 7 ng/L [odds ratio (OR) 1.82, P < 0.001] and NT‐proBNP (OR 1.98, P < 0.001) were independent predictors of ACM, while reduced left ventricular ejection fraction was not associated with increased ACM (P = 0.85). The secondary endpoint was reached by 182 patients (9.2%) with a median of 793.5 [IQR 411.2, 1165.0] days. Patients with multiple CVRFs (defined as high risk, n = 886) had an increased risk of cardiotoxicity (n = 100/886, 11.3%; hazard ratio 1.57, P = 0.004). They showed elevated baseline values of hs‐cTnT (OR 1.60, P = 0.006) and NT‐proBNP (OR 4.00, P < 0.001) and had an increased risk of ACM (OR 1.43, P = 0.031).ConclusionsIn cancer patients, CVRF accumulation predicts cardiotoxicity whereas elevated hs‐cTnT or NT‐proBNP levels are associated with ACM. Accordingly, less intensive surveillance protocols may be warranted in patients with low cardiac biomarker levels and absence of CVRFs.
Multiply Unsaturated and ω‐Brominated β‐Ketothioesters for Synthesizing β‐Ketolactams and the Scaffolds of Fully Enolized N‐Hydroxy‐3‐(polyenoyl)pyridine‐2,4‐dione Natural Products
Authors: Kopp Julia , Brückner Reinhard 
Published: November 2023

AbstractFully enolized N‐hydroxypyridine‐2,4‐diones with a 3‐enoyl or 3‐dienoyl or 3‐trienoyl substituent (collectively named “3‐polyenoyl substituent“ hereafter) define the core of a number of δ‐lactam natural products. We developed a strategy for establishing such motifs in a convergent and stereoselective manner. The polyenoyl moiety of our target molecules stemmed from simply, two‐fold or three‐fold unsaturated and almost completely enolized ω‐bromo‐β‐ketothioesters, two of which were obtained for the first time. The N‐bound hydroxy group of our target structures originated from an O‐(2,4,6‐trimethoxybenzyl)‐protected β‐(hydroxylamino)propionic ester, first obtained in this study, too. The mentioned building blocks were combined intermolecularly by a thioester hydroxylaminolysis and thereafter intramolecularly by a Williams‐type Dieckmann cyclization. The resulting N‐(2,4,6‐trimethoxybenzyloxy)dihydropyridine‐2,4‐diones were oxidized with CBrCl3 and DBU. The N‐(2,4,6‐trimethoxybenzyloxy)pyridine‐2,4‐diones gained thereby were debenzylated – jointly with their (4‐methoxybenzyl) aryl ether moiety – with F3CCO2H. This liberated the target structures.