bluuebunny/crossref_metadata_2025_split huggingface dataset:
First reports of trace element bioaccumulation in the Antarctic deep-sea squid Psychroteuthis glacialis
Authors: Lischka A. , Braid H. E. , Gaw S. , Bolstad K. S. R. 
Published: October 2023

AbstractTrophic interactions in the Antarctic Ocean are likely to be affected by changing environmental conditions. Some of these impacts can be observed, and predicted, by monitoring trace element concentrations in the tissues of animals at certain trophic levels. The ‘glacial’ squid (Psychroteuthis glacialis) is an ideal indicator species for measuring trace element bioaccumulation in the Ross Sea because it plays a central role in local marine food webs. Trace elements (Al, As, Cd, Co, Cu, Fe, Hg, Ni, Mn, Pb, U, V, and Zn) were measured in mantle and digestive gland tissues of 57P. glacialisspecimens, including juvenile and mature individuals. Significant differences in Al, As, Cd, Cu, Fe, Mn, V, and Zn concentrations were observed across life stages, with juveniles generally having the highest concentrations. As the bioaccumulation of most trace elements is influenced by diet, our results suggest different feeding patterns between juvenile and matureP. glacialis. In turn, it is likely that the life stage ofP. glacialisindividuals consumed by predators will determine trace element exposure higher up the trophic web. Overall, this Antarctic squid appears to be influenced by the trace element cycling in the Ross Sea and contains lower concentrations of trace elements than have been observed in squids in warmer waters.
Conservation Agriculture Impacts on Economic Profitability and Environmental Performance of Agroecosystems
Authors: Lorenzetti Lorenza Alexandra , Fiorini Andrea 
Published: October 2023

AbstractThe rationale of this study originates from the primary sector’s multiple roles in the global warming issue. Agriculture is reported among the main causes of anthropogenic global warming. At the same time, it is profoundly impacted by climate change and concurrently holds potential as a solution through the sequestration of soil organic carbon (SOC) facilitated by Conservation Agriculture (CA). However, the findings in the literature are controversial on the SOC sequestration capacity and the profitability of CA implementation. Considering the new and old objectives of the sector, this paper tackles the assessment of the actual capabilities of CA to be a viable strategy to pursue the social good of climate change mitigation and concurrently be profitable for farmers. The economic profitability and environmental performance of CA are assessed analysing data from a field experiment in Northern Italy (European temperate area) and identifying the best management practice by means of a data envelopment analysis.
Efficacy and safety of new-generation Bruton tyrosine kinase inhibitors in chronic lymphocytic leukemia/small lymphocytic lymphoma: a systematic review and meta-analysis
Authors: Yin Shuo , Zheng Xiaohong , Zhang Weichunbai , Zhao Hanyun , Zhang Rong , Li Wenbin , Chen Feng 
Published: October 2023

AbstractChronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a type of mature B lymphocyte clonal proliferative tumor with a specific immunophenotype. Bruton tyrosine kinase inhibitors (BTKi) have been approved for the treatment of CLL/SLL. However, the efficacy and safety of new-generation BTKi-based regimens have not been systematically studied. In this systematic review, we evaluated the efficacy and safety of new-generation BTKi-based regimens for the treatment of patients with CLL/SLL. A comprehensive search on PubMed, Embase, Cochrane Library, and ClinicalTrials.gov. up to January 31, 2023, was conducted by us. Studies reporting data on CLL/SLL patients treated with new-generation BTKi were included. We assessed the overall response rate (ORR), complete response (CR) rate, and 24-month OS/PFS rates for efficacy analysis. For safety analysis, we evaluated the incidence of grade ≥ 3 adverse events (AEs). The meta-analysis included twenty studies. The pooled ORR for new-generation BTKi was 92% (95% CI, 89–95%, I2 = 80.68%, P = 0.00), while the pooled CR rate was 10% (95% CI, 6–14%, I2 = 88.11%, P = 0.00). Research has found that the new-generation BTKi-based therapy had higher efficacy under the following treatment conditions: < 65 years old, treatment-naive (TN)-CLL, and BTKi combination therapy. The ORR/CR rates and 24-month OS/PFS rates of BTKi combination therapy were higher than that of BTKi monotherapy. Compared to acalabrutinib monotherapy, zanubrutinib monotherapy demonstrated higher ORR/CR rates and 24-month OS/PFS rates. Common grade ≥ 3 AEs included cytopenia and hypertension. The new-generation BTKi-based therapy has good tolerance and provides incremental benefits for CLL/SLL patients. Despite the superior efficacy of BTKi combination therapy compared to monotherapy, its AEs rates are relatively high. Compared to acalabrutinib, Zanubrutinib may be the preferred monotherapy for CLL. However, randomized-controlled studies are still needed.
Clinical impact of non-lying time on hospital-associated functional decline in older patients undergoing transcatheter aortic valve implantation
Authors: Kono Yuji , Mukaino Masahiko , Ozawa Yushi , Mizutani Koji , Senju Yuki , Ogasawara Takayuki , Yamaguchi Masumi , Muramatsu Takashi , Izawa Hideo , Otaka Yohei 
Published: October 2023

AbstractThe purposes of the present study were: (1) to investigate the relationship between hospital-associated functional decline (HAFD) and non-lying time and (2) to clarify the optimal cut-off value for non-lying time associated with HAFD in older patients undergoing transcatheter aortic valve implantation (TAVI). From January 2021 to December 2022, patients admitted to a university hospital who underwent trans-femoral TAVI were consecutively recruited. We measured short physical performance battery (SPPB) pre and post-TAVI, and non-lying time from post-operative days 3–5. HAFD was defined as at least 1 point decrease in SPPB during pre and post-TAVI. Among 75 patients (47 female, mean age of 84.5 years) enrolled, 14 patients were classified as having HAFD. Non-lying time was significantly shorter in the HAFD group than in the non-HAFD group (371 min vs. 539 min, P < 0.001). Receiver-operating characteristic analysis determined an optimal cut-off value of 477 min for differentiating the patients more likely to experience HAFD (sensitivity, 75%; specificity, 92%; area under the curve, 0.798). The non-lying time could be one of the associated factors of HAFD in older patients with TAVI. Non-lying time of about 480 min (8 h) during hospitalization may be an initial target for preventing HAFD.
Lymphovascular invasion and p16 expression are independent prognostic factors in stage I vulvar squamous cell carcinoma
Authors: Davidson Ben , Skeie-Jensen Tone , Holth Arild , Lindemann Kristina , Toralba Barrameda Anne Marie , Lie Agnes Kathrine , Wang Yun 
Published: October 2023

AbstractThe objective of this study was to identify clinicopathologic parameters associated with disease outcome in FIGO stage I vulvar squamous cell carcinoma (vSqCC). The cohort consisted of 126 patients diagnosed with vSqCC in the period 2006–2016 who underwent primary vulvar surgery and evaluation of groin lymph node status. Tumors were reviewed by an experienced gynecologic pathologist. p16 and p53 protein expression by immunohistochemistry and HPV status were analyzed in 116 tumors. Clinicopathologic parameters, protein expression and HPV status were analyzed for association with progression-free and overall survival (PFS, OS). p16 expression and aberrant p53 were found in 49 (42%) and 61 (53%) tumors, respectively. Sixty-six tumors were HPV-associated (57%). Relapse was diagnosed in 35/126 (28%) of patients, and 23 (18%) died of disease. Tumor diameter > 4 cm (p = 0.013), lymphovascular space invasion (LVSI; p < 0.001), the presence of lichen sclerosus (p = 0.019), p16 expression (p = 0.007), p53 expression (p = 0.012), HPV status (p = 0.021), lymph node metastasis (p < 0.001) and post-operative radiotherapy (p < 0.001) were significantly related to OS in univariate analysis. Tumor diameter > 4 cm (p = 0.038), LVSI (p = 0.003), the presence of lichen sclerosus (p = 0.004), p16 expression (p = 0.004), HPV status (p = 0.039), lymph node metastasis (p < 0.001) and post-operative treatment (p < 0.001), were significantly related to PFS in univariate analysis. Age, BMI and surgical resection involvement were not significantly associated with OS or PFS. In multivariate Cox analysis, LVSI and p16 expression were independent prognosticators of OS (p < 0.001 and p = 0.02, respectively) and PFS (p = 0.018, p = 0.037). In conclusion, LVSI and p16 expression are independent prognostic factors in stage I vSqCC.
The care burden for technology-dependent children with long-term home ventilation increases along with the improvement of their motor functions
Authors: Maeda Hirotoshi , Tomomatsu Ikuko , Iikura Izumi , Ikari Masahiro , Kondo Youichi , Yamamoto Miyuki , Tamura Masanori 
Published: October 2023

AbstractSince the establishment of Japan’s publicly supported pediatric home medical care (PHMC) system in 2012, the number of technology-dependent children (TDC) who are supported by PHMC has been increasing. We expected care to become easier as TDC mobility increased. However, many family caregivers complained of the opposite, that the burden of care increased as TDC’s mobility increased. Therefore, we aimed to study the problems of the care burden of families in relation to the improvement of mobility of TDC with a focus on respiratory support. We conducted a survey among caregivers of TDC in two parts: a first survey was done between 2018 and 2020, and a follow-up survey in 2023. In each medical procedure, the correlation of TDC’s motor function level with care burden was analyzed by using correlation analysis. In 15 households, caregivers’ activities were monitored to elucidate the problems of the care objectively. The second survey was conducted in February 2023 in TDC whose medical records were available. Analysis of 418 cases showed that care-burden increased with improvements in the children’s motor ability in tracheostomy, or remained the same in other procedures. A follow-up study in 262/418 cases of this group showed that part of these TDC with high mobility aged 1–8, after passing through the mobile phase with increased burden of care, had a high potential to be weaned from medical devices. Conclusion: For TDC who acquire motor skills during PHMC, the burden of care for caregivers either increases or remains the same. It is important to maintain social support for TDC on the recovering mobile stage.

What is Known:• There was no clear information on the care burden when TDC become mobile.

What is New:• We did a qualitative study to show that the care burden increases when TDC become mobile.• In addition, mobike TDC showed a high potential for recovery.
Mutation in Chek2 triggers von Hippel-Lindau hemangioblastoma growth
Authors: Cabrera-Montes Jorge , Aguirre Daniel T. , Viñas-López Jesús , Lorente-Herraiz Laura , Recio-Poveda Lucía , Albiñana Virginia , Pérez-Pérez Julián , Botella Luisa M. , Cuesta Angel M. 
Published: October 2023

Abstract
Purpose
Von Hippel-Lindau (VHL) is a rare inherited disease mainly characterized by the growth of tumours, predominantly hemangioblastomas (Hbs) in the CNS and retina, and renal carcinomas. The natural history of VHL disease is variable, differing in the age of onset and its penetrance, even among relatives. Unfortunately, sometimes VHL shows more severe than average: the onset starts in adolescence, and surgeries are required almost every year. In these cases, the factor that triggers the appearance and growth of Hbs usually remains unknown, although additional mutations are suspected.

Methods
We present the case of a VHL patient whose first surgery was at 13 years of age. Then, along his next 8 years, he has undergone 5 surgeries for resection of 10 CNS Hbs. To clarify this severe VHL condition, DNA from a CNS Hb and white blood cells (WBC) was sequenced using next-generation sequencing technology.

Results
Massive DNA sequencing of the WBC (germ line) revealed a pathogenic mutation in CHEK2 and the complete loss of a VHL allele (both tumour suppressors). Moreover, in the tumour sample, several mutations, in BRAF1 and PTPN11 were found. Familiar segregation studies showed that CHEK2 mutation was in the maternal lineage, while VHL was inherited by paternal lineage.

Conclusions
Finally, clinical history correlated to the different genotypes in the family, concluding that the severity of these VHL manifestations are due to both, VHL-and-CHEK2 mutations. This case report aims to notice the importance of deeper genetic analyses, in inherited rare diseases, to uncover non-expected mutations.
Die Deutsche Gesellschaft für Gefäßchirurgie und Gefäßmedizin (DGG e. V.) präsentiert ihr neues Leitbild!
Authors: Böckler D. , Adili F. , Cotta L. , Görtz H. , Heckenkamp J. , Peter J. , Schmandra Th. , Stojanovic T. , Uhl Ch. , Steinbauer M. 
Published: October 2023

ZusammenfassungDie Deutsche Gesellschaft für Gefäßchirurgie und Gefäßmedizin (DGG e. V.) hat 38 Jahre nach ihrer Gründung ein Leitbild entwickelt, um vor allem ihren Mitgliedern, aber auch Patientinnen und Patienten, dem studierenden Nachwuchs und der Öffentlichkeit eine werteorientierte Sichtbarkeit dessen zu geben, was ihr wichtig ist. Unter dem Motto„Wir sind Gefäße“ positionieren sich die DGG und ihre Mitglieder. Die DGG steht für Kompetenz und Exzellenz in der Gefäßchirurgie und Gefäßmedizin.Das Leitbild wurde in der Mitgliederversammlung der DGG e. V. an der Dreiländertagung 2022 in Wien vorgestellt und verabschiedet. Das nun vorliegende Leitbild bildet die Grundlage für eine künftige Markenbildung (Branding) der DGG und des Faches Gefäßchirurgie. Die Anpassung und Weiterentwicklung dieses Leitbildes sind zukünftig möglich und ggf. erforderlich.
Design of experiments in the optimization of all-cellulose composites
Authors: Victoria Ashley , Hine Peter John , Ward Keeran , Ries Michael Edward 
Published: October 2023

AbstractIn this work, statistical design of experiments (DoE) was applied to the optimization of all cellulose composites (ACCs) using cotton textile and interleaf films under applied heat and pressure. The effects of dissolution temperature, pressure and time on ACC mechanical properties were explored through a full factorial design (23) and later optimized using Response Surface Methodology. It was found that the experimental design was effective at revealing the underlying relationship between Young’s modulus and processing conditions, identifying optimum temperature and time settings of 101 °C and 96.8 min respectively, to yield a predicted Young’s modulus of 3.3 GPa. This was subsequently validated through the preparation of in-lab test samples which were found to exhibit a very similar Young’s modulus of 3.4 ± 0.2 GPa, confirming the adequacy of the predictive model. Additionally, the optimized samples had an average tensile strength and peel strength of 72 ± 2 MPa and 811 ± 160 N/m respectively, as well as a favorable density resulting from excellent consolidation within the material microstructure. This work highlights the potential of DoE for future ACC process understanding and optimization, helping to bring ACCs to the marketplace as feasible material alternatives.
Warming experiments test the temperature sensitivity of an endangered butterfly across life history stages
Authors: Bristow Lainey V. , Grundel Ralph , Dzurisin Jason D. K. , Wu Grace C. , Li Yudi , Hildreth Andrew , Hellmann Jessica J. 
Published: October 2023

Abstract
The Karner blue butterfly (Lycaeides melissa samuelis) (hereafter Karner blue) is a federally listed endangered species occurring in disjunct locations within the Midwest and Eastern United States. As a hostplant specialist and an ectotherm, the Karner blue is likely to be susceptible to effects of climate change. We undertook warming experiments to explore the temperature sensitivity of various Karner blue life history stages and traits. Over a two-year period, we exposed all Karner blue life stages to temperature increases of + 2, + 4, and + 6 °C above 1952–1999 mean temperatures. We analyzed the effect of these treatments on life history parameters likely related to fitness and population size, including development time, voltinism, degree-day accumulation, body weight, and morphology. Warming treatments resulted in earlier emergence and accelerated development, leading to additional generations. Warming also increased the number of degree-days accumulated during pre-adult development (i.e., egg hatch to eclosion). Results suggest that Karner blues developed in fewer days, in part, by putting on less mass as temperatures increased. As treatment temperature increased, adult body mass, length, and area decreased and voltinism increased. Females with lower adult mass and smaller body size produced fewer eggs. These results suggest a trade-off between accelerated development and decreased body size with decrease in adult mass and abdominal area being associated with reduced fecundity.

Implications for insect conservation
Changes in development timing and in voltinism can negatively affect phenological matching between the Karner blue and its obligate host plant, Wild lupine (Lupinus perennis), resulting in population decrease. Poorer phenological matching between insect and hostplant can occur across multiple generations, for example, negatively affecting overwintering population size. With increasing temperatures, smaller females will produce fewer eggs, which can also lead to poorer population outcomes across generations.
Factors influencing residential location choice in South Africa: exploratory factor analysis (EFA) and confirmatory factor analysis (CFA)
Authors: Lesia Mosala Phillip , Aigbavboa Clinton O. , Thwala Wellington D. 
Published: October 2023

AbstractThis paper employs a quantitative approach, in which a structured questionnaire containing 90 indicator variables identified from literature was administered to a total of 266 households in South Africa. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were utilised in analysing the collected data, with goodness-of-fit based on a two-index strategy used in determining model acceptability. The SEM results showed that all eight identified exogenous (independent) factors (demographic characteristics, dwelling unit features, neighbourhood features, services provided by the government, household self-congruity, functional congruity, green building features and stakeholders’ relations) had a direct positive and significant influence RLC in South Africa. The general hypothesis that the choices of households in choosing where to reside or stay are a product of the direct influence of the exogenous variables in influencing RLC in South Africa is proven. This suggested that all eight (8) variables included in the model are the most significant determinants of the RLC in South Africa.
Physics based data driven method for the crashworthiness design of origami composite tubes
Authors: Ciampaglia Alberto , Fiumarella Dario , Boursier Niutta Carlo , Ciardiello Raffaele , Belingardi Giovanni 
Published: October 2023

AbstractA novel method based on a physics informed data driven model is developed to design an origami composite crash tube. The structure consists of two axially stacked basic components, called modules. Each module presents lower and upper square sections with an octagonal section in the middle. The parameters of the octagonal cross-section and the height of each module are optimized to maximize the energy absorption of the tube when subjected to an axial impact. In contrast to standard surrogate modelling techniques, whose accuracy only depends on the amount of available data, a Physics-informed Neural Network (PINN) scheme is adopted to correlate the crushing response of the single modules to that of the whole origami tube, constraining the data driven method to physically consistent predictions. The PINN is first trained on the results obtained with an experimentally validated Finite Element model and then used to optimize the structure. Results show that the PINN can accurately predict the crushing response of the origami tube, while consistently reducing the computational effort required to explore the whole design domain. Also, the comparison with a standard Feed Forward Neural Network (FFNN) shows that the PINN scheme leads to more accurate results.
A new method for predicting hurricane rapid intensification based on co-occurring environmental parameters
Authors: Narayanan Anushka , Balaguru Karthik , Xu Wenwei , Leung L. Ruby 
Published: October 2023

AbstractTropical cyclones (TCs) that undergo Rapid Intensification (RI) can pose serious socioeconomic threats and can potentially result in major damaging impacts along coastal areas. Considering the complexity of various physical mechanisms that play a role in RI and its relatively low probability of occurrence, predicting RI remains a major operational challenge. In this study, we propose a simple deterministic binary classification model based on the co-occurrence of environmental parameters (MCE) to predict an RI event. More specifically, the model determines the possibility of RI based on a simple count of the number of environmental predictors deemed favorable and unfavorable. We compare our model results to logistic regression (LR) and decision tree (DT) models, well-trained using the same set of environmental predictors. Results reveal that at an RI threshold of 30 kt, the MCE exhibits a critical success index score of 0.233 which is 14% higher than DT and LR model performances. When tested at multiple RI thresholds, the MCE displays relatively higher skill scores across multiple metrics. By simultaneously evaluating the favorability of predictors, the MCE is able to comparatively reduce the number of false alarms predicted when certain predictors are unfavorable toward RI. Interpreting these model results to gain a physical understanding of how co-occurring environmental parameters can affect RI, we highlight future directions for using models based on the MCE approach to understand and predict TC RI as well as other meteorological extremes.