bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deformed Latest Pleistocene Fluvial Terraces Reveal Complex Active Faulting within Tectonic Transition Zone, Mendocino Triple Junction, Northern California
Authors: Nicovich Sylvia R. , Hemphill-Haley Mark , Leroy Thomas 
Published: February 2024

Abstract
The transition between the San Andreas fault (SAF) system and the southern Cascadia subduction zone (CSZ) at the Mendocino Triple Junction (MTJ) encompasses a broad zone of complex deformation, the Mendocino deformation zone. Here, there are discrepancies between types of geological structures (transform or thrust faults) and recorded geodetic velocity vectors of plate motion. Though SAF-type stress is recorded north of the MTJ, there has been little geological evidence for resultant strain at these latitudes on the coast. We focus on the Van Duzen fault (VDF)—a possible subsidiary fault of the Little Salmon fault system, one of the southernmost active thrust faults within the onshore fold and thrust belt associated with CSZ. The VDF deforms young river terraces of varying age, which we use to develop a relative-age framework to contextualize activity along the VDF. Geomorphic analysis and a paleoseismic excavation across the VDF display deformation attributed to compressional stresses, which postdates young (3–11 ka) terrace deposition, at roughly 0.06–0.38 mm/yr. We hypothesize that the transition between CSZ and SAF tectonic regimes is geologically manifest through the orientation of compressional structures (i.e., VDF), which may illuminate dynamics associated with the migrating triple junction, past and present.
Participation of Georgian Local Authorities in the Process of Hospital Care Reforms
Authors: Tegetashvili Ana , Gerzmava Otar 
Published: February 2024

The article addresses power distribution issues within the context of scientific discourse and explores potential solutions to be implemented by local authorities in the realm of Hospital Care reforms in Georgia, particularly in the conditions of authority decentralization. The significance of addressing this scientific issue stems from the financial challenges faced by many communities, especially in economically depressed Georgian regions. Prior to the reform, the network of hospital facilities relied on subsidies from higher-level budgets.
The methodological approach involves the use of desk research, secondary analysis of literary, research, and analytical sources, along with regulatory methods. The research spans from 1991 to 2022, focusing on the power of local self-governments, both their inherent powers and those delegated to them, given that almost 60% of medical services are provided at the territorial community level.
The article presents empirical analysis results regarding the distribution of financial power in the new model of Hospital care management. It demonstrates that, fundamentally, the new model remains budget-funded, consistent with the pre-reform structure. The research empirically and theoretically supports the assertion that the overall direction of reforms has been appropriately chosen, a sentiment echoed by positive assessments from international experts.
The findings of the research can be valuable for local authorities representing the interests of territorial communities and for local executive authorities involved in the implementation of these reforms. Additionally, the research aligns with Georgia's commitment to the path towards European integration changes.
This process is developing very slowly in Georgia. This is a loss of opportunity to raise the standard of living of local communities.
Communication Gaps in Georgian Palliative Medicine: Ethical and Legal Review
Authors: Tebidze N. , Kazhashvili G. 
Published: February 2024

Introduction: Difficulties in communication, decision-making, and end-of-life management have emerged in the implementation of palliative care in recent decades. The imperfection of ethical issues was also highlighted. This fact is confirmed once again by a study conducted by the oncology department of the Batumi High-technology Hospital, which aimed to study the adequate perception of existing oral pathologies by patients under palliative care and their impact on the quality of life.
Aim: We aimed to discuss the mentioned problem within the framework of bioethics and Georgian legislation.
Methods: Despite the few amount of literary sources, we tried to discuss the mentioned issue based on Georgian legislation and also existing literature.
Conclusion: Thus, as we mention in medical activities there are cases when the real diagnosis is not told to the patient for ,,his favor'', also there are cases when an inappropriate diagnosis is made, which can lead the patient to a fatal condition. In this case, the patient can civilly protect his rights.
The best option is to provide the patient with information in the correct form so that it does not mean the end of the world and does not cause depression in him. The patient should be able to pass the last stage of life peacefully and with dignity.
Pengaruh Kepemimpinan dan Motivasi Kerja Kepala Madrasah terhadap Kinerja Guru
Authors: Edi Sarwo , Subandi Subandi , Jannah Siti Roudhotul 
Published: February 2024

Kepemimpinan kepala sekolah adalah kemampuan seseorang dalam proses mempengaruhi, membimbing, mendorong,menggerakan dan mengarahkan orang lain dalam hal pembelajaran dan dapat berjalan dengan efektif. Motivasi kerja adalah sesuatu yang menimbulkan semangat atau dorongan kerja. Kinerja guru juga merupakan faktor yang menentukan berkualitas tidaknya suatu lembaga sekolah. Dari penjelasan diatas penulis menulis rumusan masalah sebagai berikut: Apakah terdapat pengaruh kepemimpinan kepala Madrasah Terhadap Kinerja Guru Pendidikan Agama Islam di MTs Darul Ulum Saukadana Lampung Timur? Apakah ada pengaruh Motivasi Kerja Kepala Madrasah terhadap kinerja guru Pendidikan Agama Islam diMTs Darul Ulum Sukadana Lampung Timur? Apakah terdapat Pengaruh Kepemimpinan dan motivasi kerja kepala madrasah terhadap kerja guru Pendidikan Agama islam di Mts Darul Ulum?,
Ditinjau dari jenisnya penelitian ini menggunakan pendekatan deskriptif kuantitatif. Tujuan penelitina kuantitatif adalah mengembangkan dan menggunakan model-model matematis, teori-teori dan hipotesis yang berkaitan dengan fenomena alam. Adapun yang menjadi populasi dalam penelitian ini adalah
10 orang guru, dan sampel yang digunakan dalam penelitian ini adalah dengan menggukan sampel jenuh yaitu seluruh guru Pendidikan Agama Islam di MTs Darul Ulum sukadana Lampung Timur ? yaitu 10 orang guru. Teknis analisis data yang digunakan untuk menguji hipotesis adalah analisis regresi sederhana dana regresis berganda, uji t dan uji F. Hasil penelitian menunjukan bahwa 1) terdapat pengaruh kepemimpinan kepala sekolah terhadap kinerja guru Pendidikan Agama islam di Mts Darul Ulum Sukadana Lampung Timur.sebesar 44,5 % yang artinya kedua variabel berjalan seiring, semakain kondusif kepemimpinan kepala sekolah maka akan semakin baik tingkat kinerja guru. 2) terdapat pengaruh motivasi kerja Kepala Madrasah terhadap kinerja guru Pendidikan agama Islam di Mts Darul Ulum Sukadana Lampung Timur, sebesar 43,8 % , artinya motivasi kerja dapat mempengaruhi aktivitas kinerja guru Pendidikan Agama Islam di Madrasah.untuk mencapai kinerja guru yang maksimal. 3) terdapat pengaruk kepemimpinan kepala Madrasah dan motivasi kerja Kepala madrasah terhadap kinerja guru di Mts Darurul Ulum Sukadana Lampung Timur,sebesar 70,3 %, kedua variabel kepemimpinan kepala Madrasah dan motivasi kerja Kepala Madrasah berjalan seiring dengan kinerja yang artinya semakin baik kepemimpinan kepala Madrasah dan motivasi kerja maka semakin tinggi pula kinerja guru Pendidikan Agama Islam tersebut.
Pengaruh Konseling Kelompok Pendekatan Realitas Terhadap Regulasi Emosi Siswa SMA Srijaya Negara Palembang
Authors: Sofah Rahmi , Azzahra Talitha Sofie 
Published: February 2024

Abstract: This study aims to determine the effect of group counseling with a reality approach to emotion regulation in students at SMA Srijaya Negara Palembang. This research is a research using experimental research methods. The type of research design used is pre-experimental design. The pre-experimental design used is a one group pretest-posttest design. The subjects of this study were 10 students from class XI IPA 1 who were identified as having low emotional regulation. Data was collected using an emotional regulation questionnaire by distributing it to respondents using a Likert scale. Data analysis used the Wilcoxon test. The results of this study based on the SPSS output show that asymp.sig (2-tailed) has a value of 0.005. Because 0.005 is less than 0.05, Ho is rejected and Ha is accepted, which means that there is an average difference between the results of the pre-test and post-test emotion regulation. So that it can be said that there is a significant effect of group counseling with the reality approach on emotion regulation in students at SMA Srijaya Negara Palembang.

Keywords: Emotion Regulation, Group Counseling, Reality Approach.
Profissionais da Informação
Authors: Santos Gildenir Carolino , Lins Edison Cardoso 
Published: February 2024

Após breve período de inatividade, retomamos as submissões de trabalho para a Revista Saberes Universitários. Desde 2019, a revista adotou a modalidade de publicação contínua, mas a quantidade de artigos submetidos não atingiu o número suficiente para dar sequência ao fluxo. Sendo assim, a partir desta edição, resolvemos incluir uma nova seção denominada “Comunicação”, que se destina a publicação de trabalhos que foram brevemente apresentados em eventos da área de atuação de cada profissional. Nesta seção, os profissionais terão a oportunidade de republicar seus trabalhos, que já foram avaliados por pareceristas duplo cego, oferecendo maior visibilidade e alcance dentro de toda a comunidade científica. Ao republicar seus trabalhos nesta seção, os profissionais compartilharão suas contribuições aos seus pares, por meio de um canal que estará sempre disponível para fomentar a participação e a produção dos funcionários da UNICAMP e da sociedade no todo. Nesta edição, destacamos a participação dos “Profissionais da Informação”, bibliotecários da Universidade que participaram do 22º Seminário Nacional de Bibliotecas Universitárias (SNBU), o qual é considerado um dos eventos mais importantes de bibliotecas universitárias, que ocorreu recentemente nos dias 27 de novembro a 01 de dezembro de 2023, na cidade de Florianópolis, sob a temática "Bibliotecas e sustentabilidade: inovação, ciência e sociedade".
Genetic insights into the social organization of Neanderthals
Authors: Skov Laurits , Peyrégne Stéphane , Popli Divyaratan , Iasi Leonardo , Devièse Thibaut , Slon Viviane , Zavala Elena , Hajdinjak Mateja , Sümer Arev , Grote Steffi , Mesa Alba Bossoms , López David , Nickel Birgit , Nagel Sarah , Richter Julia , Essel Elena , Gansauge Marie , Schmidt Anna , Korlevic Petra , Comeskey Daniel , Derevianko Anatoli , Kharevich Aliona , Markin Sergey , Talamo Sahra , Douka Katerina , Krajcarz Maciej , Roberts Richard , Higham Tom , Viola Bence , Krivoshapkin Andrey , Kolobova Kseniya , Kelso Janet , Meyer Matthias , Paabo Svante , Peter Benjamin 
Published: February 2024

Abstract
Genomic analyses of Neanderthals have previously provided insights into their population history and relationship to modern humans1–8, but the social organization of Neanderthal communities remains poorly understood. Here, we present genetic data for 13 Neanderthals from two Middle Palaeolithic sites in the Altai Mountains of southern Siberia: 11 from Chagyrskaya Cave9,10 and two from Okladnikov Cave11 - making this the largest genetic study of a Neanderthal population to date. We used hybridization capture to obtain genome-wide nuclear data, as well as mitochondrial and Y-chromosome sequences. Some Chagyrskaya individuals were closely related, including a father-daughter pair and a pair of second degree relatives, indicating that at least some of the individuals lived at the same time. Up to a third of these individuals’ genomes occur in long segments of homozygosity, suggesting that the Chagyrskaya Neanderthals were part of a small community. In addition, the Y-chromosome diversity is an order of magnitude lower than the mitochondrial diversity, a pattern that we found is best explained by female migration between communities.
Thus, the genetic data presented here provide a detailed documentation of the social organization of an isolated Neanderthal community at the easternmost extent of their known range.
Secure Transmission of Medical Image Using a Wavelet Interval Type-2 TSK Fuzzy Brain-Imitated Neural Network
Authors: Pham Duc Hung , Huynh Tuan Tu , Lin Chih-Min , Giap Van Nam , Vu Van-Phong 
Published: February 2024

Abstract
The purpose of this research is to develop a new design of a wavelet interval type-2 takagi-sugeno-kang fuzzy brain-imitated neural network (WIT2TFBINN), which is a combination of the mathematical models of a Takagi-Sugeno-Kang (TSK) fuzzy system based on wavelet interval type-2 function (WIT2) and a wavelet interval type-2 fuzzy brain imitated neural network (FBINN). The proposed WIT2TFBINN is used for synchronization control of a 4D Lorentz chaotic system and has the benefits of wavelet interval type-2 membership function, TSK fuzzy inference system, decision making, and emotional activity. To provide fast training, the proposed method's parameter update laws are derived using the gradient descent method. The proposed WIT2TFBINN synchronization technique is then applied to the transmission of medical images in a secure manner. As a cipher image, a medical image is encrypted into a chaotic trajectory. After transmission, the image can be decrypted using chaotic trajectory synchronization on the received signal. By comparing the root mean square error and statistical test results of the proposed method with recent methods, the superiority of the proposed method is demonstrated.
Refraining from closed reduction of displaced distal radius fractures in the emergency department – in short: the RECORDED trial
Authors: Derksen Bas M , Jawahier Priscilla A , Wijers Olivier , Knops Simon P , de Vries Mark R , Hooff Christiaan C Drijfhout van , Verhofstad Michiel H J , Schep Niels W L 
Published: February 2024

Abstract

• Background
With roughly 45.000 adult patients each year, distal radius fractures are one of the most common fractures in the emergency department. Approximately 60% of all these fractures are displaced and require surgery. The current guidelines advise to perform closed reduction of these fractures awaiting surgery, as it may lead to post-reduction pain relief and release tension of the surrounding neurovascular structures. Recent studies have shown that successful reduction does not warrant conservative treatment, while patients find it painful or even traumatizing. The aim of this study is to determine whether closed reduction can be safely abandoned in these patients.
• Methods
In this multicenter randomized clinical trial, we will randomize between closed reduction followed by plaster casting and only plaster casting. Patients aged 18 to 75 years, presenting at the emergency department with a displaced distal radial fracture and requiring surgery according to the attending surgeon, are eligible for inclusion. Primary outcome is pain assessed with daily VAS scores from the visit to the emergency department until surgery. Secondary outcomes are function assessed by PRWHE, length of stay at the emergency department, length of surgery, return to work, patient satisfaction and complications. A total of 134 patients will be included in this study with follow up of one year.
• Discussion
If our study shows that patients who did not receive closed reduction experience no significant drawbacks, we might be able to reorganize the initial care for distal radial fractures in the emergency department. If surgery is warranted, the patient can be send home with a plaster cast to await the call for admission, decreasing the time spend in the emergency room drastically.
Trial registration
This trial was registered in January of.
WITHDRAWN: The association between adult penile length and IQ: evidences from 139 countries
Authors: Wang Cuntong , Wangding Yihe 
Published: February 2024

Abstract
22 February, 2024. Research Square has withdrawn this preprint due to the problematic nature of the topic concerning race and intelligence. We acknowledge the sensitivities involved and the potential for misinterpretation or harm. This decision reflects our commitment to disseminate research that meets our rigorous standards for integrity and respect for all individuals. Please refer to our editorial policies page: https://www.researchsquare.com/legal/editorial for more information.
LARGE protein drives homeostatic scaling-down after long-term potentiation
Authors: Seo Bo Am , Kang Myoung-Goo , Choi Se-Young , Lee Seung-Hyun 
Published: February 2024

Abstract

In the brain, memory can be coded as relative differences in synaptic strength produced by Hebbian plasticity (e.g. LTP). However, changes in neuronal activity, including the saturation of synaptic strength by the positive-feedback nature of Hebbian plasticity, could deteriorate the encoded memory. Synaptic scaling, a type of homeostatic plasticity, is thought to contribute to the stability of the encoded memory by maintaining the relative differences in synaptic strength against persistent destabilizing changes in neuronal activity. However, it remains unclear how and when these two types of plasticity work together in the context of memory. Here, we have demonstrated that LARGE, a protein associated with intellectual disability, drives homeostatic scaling-down several hours after LTP by downregulating AMPA-receptor trafficking via the Golgi apparatus. Importantly, LARGE deficiency impairs long-term memory formation in mice. Our study reveals a potential molecular mechanism underlying the stability of memory mediated by crosstalk between Hebbian and homeostatic plasticity.
Cryptococcosis in the Immunocompetent Host: Incidence and Outcomes
Authors: Mani Valli , Hsieh Ji-Cheng , Zimilover Adam , Ghani Maham , Donaghy Henry 
Published: February 2024

Abstract
Cryptococcosis is an invasive fungal infection that typically affects immunocompromised individuals. There is limited research comparing the incidence and clinical outcomes of cryptococcosis in immunocompetent versus immunocompromised patients. Retrospective analysis was performed on patients with a confirmed positive CSF PCR, CSF antigen, or serum cryptococcal antigen tests from 5 hospitals in New York from 2017–2022. Patients were classified as immunocompromised if they had a diagnosis of HIV or active cancer, received an organ transplant, or were on immunosuppressive medications at the time of diagnosis. Baseline demographic information, comorbidities, and clinical outcomes were analyzed. 29 cases of cryptococcosis were identified with 8 cases (27.6%) occurring in immunocompetent patients. Immunocompetent patients with cryptococcosis were more likely to have a prior history of cardiac disease compared to immunocompromised patients (25% vs. 4.76%, p = 0.02). After the beginning of the COVID-19 pandemic, the proportion of immunocompetent cases increased (12% vs 35%, p = 0.03). Despite presenting with meningitis more frequently (75% vs 47.6% p = 0.08), immunocompetent patients demonstrated decreased rates of fungemia (25% vs. 33.3%, p = 0.06) and a significant decrease in mortality (12.5% vs. 23.8%, p = 0.04). Immunocompetent patients presented with meningitis more frequently and demonstrated better outcomes with decreased mortality. The proportion of immunocompetent patients increased over the study period after the beginning of the COVID-19 pandemic. Additional information about cryptococcosis in immunocompetent patients, as well as the role of cardiac disease, diabetes and COVID-19 infection as potential risk factors, warrants further study. Cryptococcosis in the Immunocompetent Host: Incidence and Outcomes
Fabrication of nitrogen-hyperdoped silicon by high-pressure gas immersion excimer laser doping
Authors: Barkby Josh , Moro Fabrizio , Perego Michele , Taglietti Fabiana , Lidorikis Elefterios , Kalfagiannis Nikolaos , Koutsogeorgis Demosthenes , Fanciulli Marco 
Published: February 2024

Abstract

In recent years, research on hyperdoped semiconductors has accelerated, displaying dopant concentrations far exceedingsolubility limits to surpass the limitations of conventionally doped materials. Nitrogen defects in silicon have been extensivelyinvestigated for their unique characteristics compared to other pnictogen dopants. However, previous practical investigationshave encountered challenges in achieving high nitrogen defect concentrations due to the low solubility and diffusivity ofnitrogen in silicon, and the necessary non-equilibrium techniques, such as ion implantation, resulting in crystal damage andamorphisation. In this study, we present a single-step technique called high-pressure gas immersion excimer laser doping(HP-GIELD) to manufacture nitrogen-hyperdoped silicon. Our approach offers ultrafast processing, scalability, high control, andreproducibility. Employing HP-GIELD, we achieved nitrogen concentrations exceeding 6 at. % (3.01 x 1021 at./cm3) in intrinsicsilicon. Notably, nitrogen concentration remained above the liquid solubility limit to ∼1 μm in depth. HP-GIELD’s high-pressureenvironment effectively suppressed surface damage, while the well-known effects of pulsed laser annealing (PLA) preservedcrystal quality. Additionally, we conducted a theoretical analysis of light-matter interactions and thermal effects governingnitrogen diffusion during HP-GIELD, providing insights into the doping mechanism. Leveraging excimer lasers, our method iswell-suited for integration into high-volume semiconductor manufacturing, particularly front-end-of-line processes.
A novel C-29 oxidase, CYP712D39, catalyzes the formation of bryonolic acid from isomultiflorenol in Trichosanthes cucumerina L.
Authors: Lertphadungkit Pornpatsorn , Mekloy Paktaporn , Bunsupa Somnuk 
Published: February 2024

Abstract
Bryonolic acid, a characteristic triterpenoid in Trichosanthes cucumerina L., is well-known due to its pharmacological activities. The biosynthetic pathway of this compound is similar to other triterpenoids, which are known to be initiated by oxidosqualene cyclase for squalene cyclization and cytochrome P450s for oxidation. However, the final step in this pathway has not been identified. This study presents a discovery of a novel enzyme, CYP712D39, with the remarkable ability to catalyze the crucial C-29 oxidation step in bryonolic acid production. We utilized previous transcriptome analysis with eight promising P450 candidates, exhibiting greater expression levels in callus tissue, which shows a high bryonolic acid production. Functional characterization experiment confirmed its capacity to convert isomultiflorenol into bryonolic acid in the WAT11 yeast system. Furthermore, we also predicted key amino acids, including F113, crucial for binding with C3-OH of isomultiflorenol for C29-oxidation. This discovery fills a critical knowledge gap and offers significant biotechnological potential for pharmaceutical and agricultural applications.