bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Climatic Conditions, Human Activities, and Catchment Characteristics on the Propagation From Meteorological to Agricultural and Hydrological Droughts in China
Authors: Cheng Xing , Xu Yuyue , Chen Jianli , Liu Qing 
Published: December 2023

AbstractDroughts are one of the most frequent and destructive natural disasters worldwide. In the past decades, drought events in China are frequent and caused severe socio‐economic losses. To better predict and manage droughts, the spatiotemporal characteristics of the three types of droughts and propagation time (PT) from meteorological to agricultural and hydrological droughts in China during 1982–2014 were analyzed based on drought indices, while the causes of drought propagation were discussed. The results showed that meteorological droughts exhibited an insignificant trend. Agricultural droughts mainly aggravated in the northeastern and central regions. And the hydrological droughts were long‐lasting and exacerbated in most areas. The propagation speed from meteorological to agricultural and hydrological droughts was extremely rapid (1–2 months) in southeast China, and the relationships among droughts were close (correlation coefficient/R > 0.6). The propagation from meteorological to hydrological droughts was slower (6–8 months) in central China. In northwest China, the association between meteorological and hydrological droughts was weak (R < 0.4). Climatic conditions (especially temperature) played a dominant role in the propagation from meteorological to agricultural and hydrological droughts, explaining 63.3% and 52.6% of the variations in the PT, respectively. Urbanization, agricultural activities, elevation, and vegetation contributed to the propagation from meteorological to agricultural droughts. Reservoirs, agricultural activities, and vegetation also affected the propagation from meteorological to hydrological droughts by regulating hydrological processes. These findings are of vital significance to the prediction, warning, and management of different droughts.
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib
Authors: Okamoto Masaki , Fujimoto Kiminori , Johkoh Takeshi , Kawaguchi Atsushi , Mukae Hiroshi , Sakamoto Noriho , Ogura Takashi , Ikeda Satoshi , Kondoh Yasuhiro , Yamano Yasuhiko , Komiya Kosaku , Umeki Kenji , Nishikiori Hirotaka , Tanino Yoshinori , Tsuda Toru , Arai Naoki , Komatsu Masamichi , Sakamoto Susumu , Yatera Kazuhiro , Inoue Yoshikazu , Miyazaki Yasunari , Hashimoto Seishu , Shimizu Yasuo , Hozumi Hironao , Ohnishi Hiroshi , Handa Tomohiro , Hattori Noboru , Kishaba Tomoo , Kato Motoyasu , Inomata Minoru , Ishii Hiroshi , Hamada Naoki , Konno Satoshi , Zaizen Yoshiaki , Azuma Arata , Suda Takafumi , Izuhara Kenji , Hoshino Tomoaki 
Published: December 2023

AbstractThis study investigated the utility of periostin, a matricellular protein, as a prognostic biomarker in patients with idiopathic pulmonary fibrosis (IPF) who received nintedanib. Monomeric and total periostin levels were measured by enzyme-linked immunosorbent assay in 87 eligible patients who participated in a multicenter prospective study. Forty-three antifibrotic drug-naive patients with IPF described in previous studies were set as historical controls. Monomeric and total periostin levels were not significantly associated with the change in forced vital capacity (FVC) or diffusing capacity of the lungs for carbon monoxide (DLCO) during any follow-up period. Higher monomeric and total periostin levels were independent risk factors for overall survival in the Cox proportional hazard model. In the analysis of nintedanib effectiveness, higher binarized monomeric periostin levels were associated with more favorable suppressive effects on decreased vital capacity (VC) and DLCO in the treatment group compared with historical controls. Higher binarized levels of total periostin were associated with more favorable suppressive effects on decreased DLCO but not VC. In conclusion, higher periostin levels were independently associated with survival and better therapeutic effectiveness in patients with IPF treated with nintedanib. Periostin assessments may contribute to determining therapeutic strategies for patients with IPF.
Increased sodium fluorescein transport by corticosteroids is inhibited by a LAT-1 specific inhibitor in retinal pigment epithelial cells in vitro
Authors: Misawa Norihiko , Honda Shigeru 
Published: December 2023

AbstractTo investigate whether aldosterone (ALD) and hydrocortisone (HC) change the gene expression of SLC7A5, which encodes the large neutral amino acid transporter small subunit 1 (LAT1), and the transport activity of LAT1 in the retinal pigment epithelium (RPE) in vitro. ARPE-19 cells were grown to confluence. After withdrawing the serum, ALD or HC was added with several doses and incubated, and SLC7A5 gene expression was measured. The influx and efflux transport of sodium fluorescein (Na-F) were evaluated using the Transwell culture system. SLC7A5 gene expression was upregulated by ALD and downregulated by HC in a dose-dependent manner. Both ALD and HC significantly increased the influx and efflux Na-F transport of RPE cells at a dose that did not change the expression of SLC7A5. JPH203, a specific inhibitor of LAT1, significantly reduced accelerated Na-F transport. Both ALD and HC increased the gene expression of zonula occludin-1 (ZO-1) although they did not change the immunoreactivity of ZO-1 in RPE cells. LAT1 may play an important role in increasing Na-F transport associated with ALD and HC administration. A specific LAT1 inhibitor may effectively regulate the increased material transport of RPE induced by ALD and HC.
Biomechanical study of posterior cruciate ligament tibial arrest avulsion fracture fixation with triple tibial channel net sutures
Authors: Li Yuan , Liu Jun-Cai , Wu Ju , Peng Xu , Sun Guan-Jun , Li Zhong , Yin Yi 
Published: December 2023

AbstractTo investigate the biomechanical properties of posterior cruciate ligament avulsion fractures of the tibia fixed using four different methods, including triple tibial channel net suture fixation. In 40 porcine knees, a standardized bony avulsion of the posterior cruciate ligament was generated. Double tibial bone channel suture fixation was performed in group A, double-head hollow compression screw fixation was performed in group B, triple tibial bone channel net suture fixation was performed in group C, and cortical suspension EndoButton fixation was performed in group D. The constructs were cyclically loaded 500 times (10 to 100 N) to measure the initial displacement and stiffness values. Subsequently, loading to failure was performed, and the yield load and peak load were measured. The results were analysed by one-way ANOVA, with significance set at P < 0.05. The initial displacement in group D (1.00 ± 0.20 mm) was lower than that in group C (1.46 ± 0.33 mm, P = 0.000), group B (1.91 ± 1.71 mm, P = 0.000) and group A (3.91 ± 0.79 mm, P = 0.000), but there was no significant difference between groups B and C (P = 0.055). The initial stiffness in group A (50.59 ± 6.89 N/mm) was lower than that in group C (67.21 ± 12.80 N/mm, P = 0.001), group D (71.18 ± 9.20 N/mm, P = 0.000) and group B (78.67 ± 5.91 N/mm, P = 0.000). However, there was no significant difference between groups B and D or between groups C and D (P = 0.111 and P = 0.391). The yield load in group A (554.86 ± 71.43 N) was lower than that in group C (767.00 ± 34.53 N, P = 0.000), group D (777.62 ± 73.03 N, P = 0.000) and group B (837.50 ± 55.73 N, P = 0.000). There was no significant difference between groups C and D (P = 0.729). The peak load in group A (667.38 ± 61.54 N) was lower than that in group C (842.00 ± 26.20 N, P = 0.000), group D (867.63 ± 63.42 N, P = 0.000) and group B (901.25 ± 54.38 N, P = 0.000). There was no significant difference between groups C and D (P = 0.346). Different failure modes were found among the four groups. The triple tibial bone channel suture fixation group showed better initial stability and fixation strength, which was comparable to that in the cortical suspension EndoButton fixation group and double-head hollow compression screw fixation group and significantly stronger than that in the double tibial bone channel suture fixation group. This study analysed the dynamic and static indexes of posterior cruciate ligament tibial avulsion fractures fixed by four different fixation methods under cyclic loading tests and single failure loading tests, providing a theoretical basis for clinical treatment.
A phase shift keying modulator integrated single‐feed circular polarization agile array antenna
Authors: Phyoe Thet Paing , Hasan Maodudul , Nishiyama Eisuke , Toyoda Ichihiko 
Published: December 2023

AbstractThis paper proposes a novel design of a circular polarization agile array antenna using two phase shift keying (PSK) modulators. The proposed antenna includes four dual linear polarization microstrip patch antenna elements, two PSK modulators, two quarter‐wavelength slot transmission lines, microstrip‐slot line transitions, and a single feed network. The PSK modulator generates phase switching of either 180° or 0° of the vertical signals of each antenna element with the aid of the four diodes. The quarter‐wavelength slot transmission lines are added to adjust the 90° phase difference between orthogonal signals of the array antenna. By controlling the PSK modulators, the proposed antenna can achieve dual circular polarization switching capabilities. A prototype antenna is used to demonstrate the antenna concept. The measured results confirm the concept with a good agreement between the simulated and measured performances. The proposed antenna has no complex circuits for RF and DC signals, and it provides a compact structure.
A Tool to Identify and Engage Patients on Risky Opioid Regimens
Authors: Griffin Ashley C. , Perez Taryn , Avoundjian Tigran , Becker William , Midboe Amanda M. 
Published: December 2023

Abstract
Background Concerns around opioid safety for patients living with chronic pain have led to a growing number of collaborative and multimodal pain care initiatives. A major challenge in these efforts has been identifying and engaging patients on high-risk opioid regimens in a timely manner.
Objectives In this clinical informatics case report, we describe the development and implementation of a web-based tool to support providers as they implement an integrated pain support clinical initiative at primary care clinics across three health care systems.
Methods The tool identifies patients on risky opioid medication regimens and generates autopopulated patient outreach letters. It contains three core functions that: (1) identify patients prescribed high-dose opioids or coprescribed opioids and benzodiazepines, (2) generate automated letters for patients with an upcoming primary care appointment, and (3) allow clinic staff to write back to a database to track outreach and referrals. Qualitative stakeholder feedback was gathered through interviews and user testing to assess perceived usefulness and ease of use of the tool.
Results Over a 24-month period, the tool identified 1,125 patients prescribed risky medication regimens and generated 1,315 total letters as some patients became reeligible. Stakeholder feedback revealed that the tool was useful to quickly find patients on risky medication regimens and efficient in generating prepopulated letters that could be mailed in large batches. Additional feedback led to iterative refinements and improved system capabilities that varied across clinics.
Conclusion Deploying clinical informatics tools that prioritize, engage, and track high-risk patient populations supports reduction of risky medication regimens. Such tools can reduce workload burden on busy primary care staff, particularly during implementation studies, and enhance patient-centered care through the use of direct-to-consumer outreach.
Expert Evidence and Digital Open Source Information
Authors: Gillett Matthew , Fan Wallace 
Published: December 2023

Abstract
Digital open source information (DOSI) has emerged as a significant source of evidence for the International Criminal Court (‘the Court’) and other jurisdictions applying international criminal law. However, its use in litigation raises questions about who can be considered an expert in DOSI and what methods and safeguards they should adopt. This article examines how the Court can receive DOSI via expert evidence while maintaining rigorous fact-finding standards. It addresses challenges that DOSI introduces to the paradigm of expert testimony, including the lack of an overarching formalized system of DOSI accreditation, the typically group-based nature of DOSI investigations and the scope for misinterpretations and biases to result in erroneous conclusions. It proposes a novel six-factor test for the Court’s identification of sufficiently qualified DOSI specialists as expert witnesses. At the same time, it highlights that DOSI specialists should utilize transparent, accessible and replicable methodologies, with quality control feedback loops, peer review processes and bias controls. The aim of the article is to facilitate the use of DOSI evidence to resolve atrocity crimes cases, while also maintaining rigorous fact-finding standards and conforming with due process and fair trial rights.
Current assessment and management of measurable residual disease in patients with acute lymphoblastic leukemia in the setting of CAR-T-cell therapy
Authors: Lin Minghao , Zhao Xiaosu , Chang Yingjun , Zhao Xiangyu 
Published: December 2023

Abstract
Chimeric antigen receptor (CAR)-modified T-cell therapy has achieved remarkable success in the treatment of acute lymphoblastic leukemia (ALL). Measurable/minimal residual disease (MRD) monitoring plays a significant role in the prognostication and management of patients undergoing CAR-T-cell therapy. Common MRD detection methods include flow cytometry (FCM), polymerase chain reaction (PCR), and next-generation sequencing (NGS), and each method has advantages and limitations. It has been well documented that MRD positivity predicts a poor prognosis and even disease relapse. Thus, how to perform prognostic evaluations, stratify risk based on MRD status, and apply MRD monitoring to guide individual therapeutic decisions have important implications in clinical practice. This review assesses the common and novel MRD assessment methods. In addition, we emphasize the critical role of MRD as a prognostic biomarker and summarize the latest studies regarding MRD-directed combination therapy with CAR-T-cell therapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT), as well as other therapeutic strategies to improve treatment effect. Furthermore, this review discusses current challenges and strategies for MRD detection in the setting of disease relapse after targeted therapy.
Impact of Maximum Point Dose Within the Planning Target Volume on Local Control of Nonsmall Cell Lung Cancer Treated With Stereotactic Body Radiotherapy
Authors: Braschi Erica L. , Morris Christopher G. , Yeung Anamaria R. , De Leo Alexandra N. 
Published: December 2023

Objective:
No consensus exists on the maximum dose delivered to the planning target volume (PTV) in the delivery of stereotactic body radiotherapy (SBRT) for primary lung cancer. We investigated whether higher biologically effective doses (BED) within the PTV were associated with improved tumor control.

Methods:
We reviewed patients with early-stage, node-negative nonsmall cell lung cancer who received curative-intent SBRT between 2005 and 2018. We calculated the maximum BED (maxBED) within the PTV for all patients, analyzing outcomes using the cumulative incidence method and Fine-Gray test statistics to assess prognostic impact.

Results:
We analyzed 171 patients (median age, 70.2; range, 43 to 90 y) with 181 lung nodules. Median follow-up was 2.7 years (range, 0.1 to 12 y) for all patients and 4.2 years (range, 0.2 to 8.4 y) for living patients. Median maximum tumor diameter was 1.9 cm (range, 0.7 to 5.6 cm). Patients received a prescription of 48 or 50 Gy in 4 or 5 fractions, respectively, except for one who received 60 Gy in 5 fractions. Median maxBED was 120 Gy (range, 101 to 171 Gy). There was no difference in the 3-year local control (LC) rate among patients treated with a maxBED<120 Gy versus ≥120 Gy (P=0.83).

Conclusion:
No significant differences in LC were observed between patients with early-stage nonsmall cell lung cancer treated with SBRT in 4 or 5 fractions with a maxBED≥120 Gy. However, a higher maxBED trended toward improved LC rates, suggesting a maxBED threshold greater than 120 Gy may be needed to improve LC rates.
International Expert Consensus on Defining Textbook Oncologic Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastasis
Authors: Zohar Nitzan , Nevler Avinoam , Esquivel Jesús , Yeo Charles J , Benvenisti Haggai , Elbaz Nadav , Assaf Dan , Mor Eyal , Bowne Wilbur B ,   for The International TOO HIPEC Consensus Group
Published: December 2023

BACKGROUND:Textbook oncologic outcome (TOO) is a composite metric shown to correlate with improved survival after curative intent oncologic procedures. Despite increasing use among disciplines in surgical oncology, no consensus exists for its definition in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).STUDY DESIGN:An international consensus-based study employed a Delphi methodology to achieve agreement. Fifty-four senior surgeons from the peritoneal surface malignancies field received a questionnaire comprising TOO parameters divided into 3 surgical domains: operative, short-term, and long-term postoperative outcomes. Two online meetings with participants defined the new criteria. Consensus was achieved when 75% of agreement rate was reached. Clinical data of patients who underwent CRS and HIPEC for colorectal peritoneal metastasis between 2010 and 2022 from 1 designated center (Sheba Medical Center) were collected, the consensus definition applied and outcomes analyzed.RESULTS:Thirty-eight surgeons (70%) participated. Expert consensus TOO parameters for colorectal peritoneal metastasis CRS and HIPEC included the absence of unplanned reoperations during 30 days postoperation, absence of severe postoperative complications (Clavien-Dindo ≥III), absence of unplanned readmissions during 30 days postoperation, 90-day postoperative mortality, and absence of contraindications for chemotherapy within 12 weeks from operation, and included the achievement of complete cytoreduction (CC0). The study cohort consisted of 251 patients, and 151 (60%) met TOO criteria. Patients who achieved TOO had significantly better overall survival (median 67.5 months, 95% CI) vs patients who did not achieve TOO (median 44.6 months, 95% CI, p < 0.001) and significantly improved disease-free survival (median, 12 months, 95% CI, vs 9 months, 95% CI, p = 0.01).CONCLUSIONS:Achievement of TOO as defined by consensus statement is associated with improved survival.
Naturalistic Movies and Encoding Analysis Redefine Areal Borders in Primate Visual Cortex
Authors: Shimaoka Daisuke , Wong Yan Tat , Rosa Marcello GP , Price Nicholas Seow Chiang 
Published: December 2023

AbstractAccurate definition of the borders of cortical visual areas is essential for the study of neuronal processes leading to perception. However, data used for definition of areal boundaries has suffered from issues related to resolution, uniform coverage, or suitability for objective analysis, leading to ambiguity. Here, we present a novel approach that combines widefield optical imaging, presentation of naturalistic movies, and encoding model analysis, to objectively define borders in the primate extrastriate cortex. We applied this method to test conflicting hypotheses about the third-tier visual cortex, where areal boundaries have remained controversial. The results support a hypothesis whereby an area contains representations of both the upper and lower contralateral quadrants (DM) is located immediate anterior to V2, and unveil pronounced tuning preferences in the third-tier areas. High-density electrophysiological recordings with a Neuropixels probe confirm these findings. Our encoding-model approach offers a powerful, objective way to disambiguate areal boundaries.
Effects of Prospective Motion Correction on Perivascular Spaces at 7T MRI Evaluated Using Motion Artifact Simulation
Authors: Zhao Bingbing , Zhou Yichen , Zong Xiaopeng 
Published: December 2023

AbstractPurposeProspective motion correction (PMC) is a promising method in mitigating motion artifacts in MRI. However, its effectiveness in improving the visibility of vessel-like thin structures in routine studies is unclear. In this study, we aim to demonstrate the ability of fat-navigator based PMC in improving the visibility of perivascular spaces (PVS) using data from two earlier studies.MethodsTwo open source MRI data set were used for motion artifact simulation and evaluating PMC, which consist of 66 T2-weighted images without PMC and 38 T2-weighted images with PMC. PMC was performed by adjusting field of view during scan based on motion parameters derived from fat navigators. Motion artifact simulation was performed by misplacing k-space data at a motion-related non-cartesian grid onto the cartesian grid calculated using motion-free images to generate the images without effects of PMC. The simulation’s ability to reproduce motion-induced blurring and ringing artifacts was evaluated using the sharpness at the lateral ventricle/white matter (WM) boundary and the magnitude of ringing artifact component in the Fourier spectrum. PVS volume fraction in WM was employed to reflect its visibility. Sharpness, magnitude of ringing artifact and PVS volume fraction were then compared between simulated images and real images with and without PMC.ResultsThe consistencies in sharpness (rho ≥ 0.86, corrected p ≤ 4.4 ×10-16) and ringing artifact magnitude (rho ≥ 0.42, corrected p ≤ 0.001) were found between simulated images and real images without PMC. There was a significant negative correlation (rho ≤ -0.27, corrected p ≤ 0.08) between PVS volume fraction and motion severity in both simulated and real images without PMC. PMC removed the above correlations (rho ≥ -0.02, corrected p > 1) and increased the boundary sharpness compared to the images simulated using the same motion traces.ConclusionsMotion artifact simulation can reproduce the desired motion-induced artifacts on images. PMC reduces the negative impacts of motion on image quality and improves PVS visibility.