bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of brexpiprazole, aripiprazole, and placebo for Japanese major depressive disorder: A systematic review and network meta‐analysis
Authors: Kishi Taro , Sakuma Kenji , Saito Takeo , Nakagawa Atsuo , Kato Masaki , Iwata Nakao 
Published: January 2024

AbstractAimThis systematic review and frequentist network meta‐analysis used random‐effects models is conducted to determine whether there are differences in the efficacy, acceptability, tolerability, and safety profiles of brexpiprazole (BRE) and aripiprazole (ARI) for Japanese with major depressive disorder (MDD) who were inadequately responsive to antidepressants.MethodsOutcome measures were scores on the Montgomery Åsberg Depression Rating Scale (primary), the Clinical Global Impression severity scale, and social functioning scale; the non‐response rate; the non‐remission rate; all‐cause discontinuation; discontinuation due to adverse events (DAE); at least one adverse event (1AE); serious adverse event, akathisia; tremor; weight gain.ResultsA literature search identified three double‐blind, randomized, placebo‐controlled trials. These comprised one BRE study (with a 1 mg/day [BRE1] and a 2 mg/day [BRE2]) and two ARI studies (with a 3 mg/day arm and a flexible‐dose arm[within the dosage range approved in Japan]) (n = 1736). Both BRE and ARI demonstrated better efficacy than the placebo. BRE but not ARI had a higher DAE than the placebo. ARI but not BRE had a higher 1AE than the placebo. BRE and ARI had a higher risk of akathisia and weight gain than the placebo. There were no significant differences between BRE and ARI for any of the outcomes. Although BRE1 had good efficacy, it carried risk of weight gain. Although BRE2 also had efficacy, it carried risks of DAE, akathisia, and weight gain. However, the risk of akathisia in BRE2 was reduced by an initial dose of 0.5 mg/day rather than 1.0 mg/day.ConclusionsOverall BRE showed similar utility to ARI and a good risk–benefit balance.
Adult Laryngomalacia: A Scoping Review
Authors: Mills John F. , Monaghan Neil P. , Nguyen Shaun A. , O'Rourke Ashli K. , Halstead Lucinda A. , Meyer Ted A. 
Published: January 2024

AbstractObjectiveThis review sought to determine the characteristics of adults diagnosed with new onset laryngomalacia including airway symptoms, laryngoscopic findings, treatments, and outcomes. Moreover, we wanted to highlight suspected limitations in the literature.Data SourcesStudies were identified through CINAHL, Cochrane Review, PubMed, and Scopus published between 1966 and 2023.Review MethodsThe search was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐analysis Extension for Scoping Reviews checklist by 2 independent investigators. A meta‐analysis of proportions and continuous measures was conducted.ResultsOf the 1121 abstracts identified, 33 articles pertaining to laryngomalacia in the adult population were included. The most common presenting symptoms were stridor at rest (78.3%, 65.1‐88.3) and dyspnea with exertion (83.8%, 64.8‐96.3). The most suspected etiology was exercise‐induced (86.0%, 69.4‐95.5), and the most common description of laryngomalacia on visualization was collapse of supraglottic structures during exercise (93.3%, 79.0‐99.1). Nonsurgical options were attempted in 87.0% (54.0‐99.1), which included oral appliances, respiratory retraining, breathing techniques, and working with a speech pathologist. Surgical options were ultimately performed in 84.2% (75.0‐91.0). Complete resolution of symptoms following therapy was seen in 61.9% (48.0‐74.6).ConclusionAdult onset laryngomalacia is difficult to characterize. It typically presents in patients during exercise, with neurological injury, or idiopathically. Surgical management can lead to improvement or complete resolution of symptoms. The need for a universal nomenclature is highlighted in this review, as it is inconsistently classified.
Trends in Medicare Reimbursements for Commonly Performed Laryngeal Procedures from 2000 to 2021
Authors: Patel Rahul A. , Torabi Sina J. , Izreig Said , Peter Manes R. 
Published: January 2024

AbstractObjectiveNumerous studies among different specialties have suggested that inflation‐adjusted Medicare reimbursements have steadily declined in the last few decades. The objective of this study is to investigate whether this is true within the field of laryngology.Study DesignRetrospective Cross‐Sectional Study.SettingCenters for Medicare & Medicaid Services (CMS) Physician Fee Schedule.Methods2000‐2021 fees for laryngeal surgeries (Current Procedural Terminology [CPT] codes 31530, 31531, 31535, 31536, 31540, 31541, 31545, 31546, 31551‐31554, 31560, 31561, 31570), and laryngectomies (CPTs 31360, 31365, 31367, 31368, 31370, 31375, 31380, 31382, 31390, 31395) were gathered. United States consumer price index (CPI) was used to adjust all gathered data for inflation to 2021 US dollars.ResultsDuring the study period, unadjusted reimbursement for non‐facility and facility laryngeal surgeries decreased an average of 6.1% and 6.6%, respectively. When adjusting for inflation, non‐facility and facility laryngeal surgeries saw an average decrease of 17.8% (p < 0.001) and 28.5% (p < 0.001), respectively. Unadjusted reimbursement for facility laryngectomies saw an average increase of 40.2%, correlating to an inflation‐adjusted decline of 8.9% (p < 0.001). Among laryngeal procedures overall, there was an average nominal increase of 17.0%, correlating to a 20.3% inflation‐adjusted decline.ConclusionIn terms of inflation‐adjusted dollars, reimbursements for laryngeal procedures have seen a large decrease in the last two decades. Understanding reimbursement trends is critical for sustainability of otolaryngology practices, and can be used by surgeons, hospital systems, and policymakers to guide future healthcare legislation.
Is Public Interest Associated with Real‐World Management of Ankyloglossia?
Authors: Naseem Danial F. , Sheth Amar H. , Cheng Alan G. , Qian Z. Jason 
Published: January 2024

AbstractObjectivesAssess the relationship between public interest in ankyloglossia as determined by internet search volume and real‐world medical claims data.Study DesignRetrospective Cohort Study.SettingThis retrospective cohort study was conducted using claims data from the Merative™ Marketscan® Research Databases. The internet search data was collected from Google Trends.MethodsAnnual Google Trends data were compiled using search terms associated with “ankyloglossia” and “frenotomy” for the years 2011 to 2021. We obtained incidence of ankyloglossia diagnoses and frenotomy procedures in children under 12 months from Marketscan relative to all infants enrolled. We compared associations between search and incidence data among US states and over time.ResultsGoogle search correlated with ankyloglossia incidence (r = 0.4104, P = .0031) and with frenotomy incidence (r = 0.4062, P = .0034) per state. Ankyloglossia diagnoses increased with Google search index (coefficient = 0.336, 95% confidence interval [CI] 0.284, 0.388) and year (coefficient = 0.028, 95% CI 0.025, 0.031). Similarly, frenotomy procedures increased with Google search index (coefficient = 0.371, 95% CI 0.313, 0.429) and year (coefficient = 0.027, 95% CI 0.024, 0.030).ConclusionsAssociations between online ankyloglossia search trends and both diagnosis and treatment rates, persist across US regions and timeframes. Internet search trends are pivotal in shaping pediatric health care decisions, driving clinical consensus, and disseminating evidence‐based information.
Predictors of Non‐Rhinogenic Facial Pain or Pressure in Otolaryngology Clinic
Authors: Altonji Samuel , Del Risco Amanda , Kilpatrick Kayla W. , Kuchibhatla Maragatha , Abi Hachem Ralph , Jang David W. 
Published: January 2024

AbstractObjectivesIdentify demographic and clinical characteristics that may help differentiate non‐rhinogenic facial pain or pressure (NRFP) from sinusitis.Study DesignRetrospective single‐institution study.SettingTertiary Care Center Rhinology Clinic.MethodsAll patients presenting with a complaint of facial pain or pressure over a 3‐year period were included. Patients were categorized into either NRFP or sinusitis groups based on computed tomography imaging and nasal endoscopy. Data pertaining to demographics, history, and SNOT‐22 questionnaire domains were compared via univariate analysis as well as logistic regression with backwards variable selection.ResultsA total of 296 patients met inclusion criteria, of which 128 had NRFP and 168 had sinusitis. A significantly greater percentage of patients in the NRFP group were women of childbearing age (40.6% vs 28.0%, P = .02). Backwards variable selection resulted in a model with four variables predicting a diagnosis of NRFP–female sex (odds ratio [OR] = 2.998, P < .0001), no history of prior sinonasal surgery (OR = 0.340 for history vs no history, P < .01), low nasal domain score (OR = 0.551, P < .0001), and high ear/facial domain score (OR = 1.453, P < .01).ConclusionAccurately identifying patients with NRFP at initial presentation based on history would help direct patients to the appropriate care pathway and prevent ineffective treatments such as antibiotics and sinus procedures. Our findings suggest that the suspicion for NRFP should be higher in women of child‐bearing age as well as patients with greater ear/facial symptoms or lesser nasal symptoms.
Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies
Authors: Chang Katherine W. , Mazul Angela L. , Lander Daniel P. , Wahle Benjamin M. , Yan Emily Z. , Thorstad Wade L. , Puram Sidharth V. , Jackson Ryan S. , Pipkorn Patrik , Paniello Randal C. , Zolkind Paul A. , Olshan Andrew F. , Zevallos Jose P. 
Published: January 2024

AbstractObjectiveTo determine the association between poor dental health and risk of oral cavity squamous cell cancer (OCSCC) at individual tumor subsites.Study DesignCase‐control and cross‐sectionalMethodsA case‐control study was performed using a population‐based cohort in North Carolina (Carolina Head and Neck Cancer Epidemiology Study [CHANCE]). A secondary cross‐sectional analysis was performed with an institutional cohort (WashU/Siteman). Cases were adults with primary OCSCC and an identifiable tumor subsite. In the CHANCE cohort, controls were adults without head and neck cancer. In the Washington University/Siteman cohort, patients with tongue cancer served as the comparator group. We used number of missing teeth (categorized 0‐6, 7‐24, 25‐28) as a surrogate for poor dental health, which was self‐reported in CHANCE and measured on a pretreatment computed tomography scan in the WashU/Siteman study. Adjusted odds ratios (aORs) for missing teeth were estimated for each tumor subsite using binomial logistic regression models.ResultsNear complete tooth loss (25‐28 teeth) was associated with a 3.5‐fold increased risk of alveolar ridge malignancy (aOR: 3.51; 95% confidence interval [CI]: 1.14‐11.01, P = .03) in the CHANCE study. This association was confirmed in our cross‐sectional analysis (WashU/Siteman study) where missing 25‐28 teeth was associated with an increased risk of alveolar ridge compared to tongue cancer (aOR: 4.60; 95% CI: 1.97‐11.10, P = .001).ConclusionsThis study suggests an association between poor dental health and risk of alveolar ridge cancer independent of smoking, alcohol use, age, race, and sex. Future prospective and translational studies are needed to confirm this association and elucidate the mechanism of dental disease in alveolar ridge malignancies.
Simultaneous rapid detection of glycyrrhizin and sennoside A in Daiokanzoto samples by lateral flow immunoassay
Authors: Ochi Akihiro , Nuntawong Poomraphie , Chaingam Jiranan , Ota Tomoki , Juengwatanatrakul Thaweesak , Putalun Waraporn , Shoyama Yukihiro , Tanaka Hiroyuki , Morimoto Satoshi , Sakamoto Seiichi 
Published: January 2024

AbstractIntroductionGlycyrrhizin (GLY) and sennoside A (SA) are characteristic bioactive marker compounds of the Kampo medicine Daiokanzoto. Their accurate detection in blends of Rhei rhizoma and Glycyrrhizae radix of several species (4:1 or 4:2) is essential for quality control and to ensure therapeutic efficacy. A rapid, efficient assay can significantly facilitate their detection.ObjectiveTo establish a rapid qualitative assay for GLY and SA detection, a lateral flow immunoassay (LFA) was developed using specific monoclonal antibody (mAb) nanoparticles.MethodologyThis assay harnesses the competitive binding of mAb nanoparticles to the immobilized analytes on test strips and free analytes in the samples. Two conjugates for detecting GLY and SA, GLY–bovine serum albumin and SA–human serum albumin, were separately immobilized on the test zones of LFA strips. The detection mechanism is reliant on the visual detection of color changes in the test zones.ResultsWhen GLY and SA were present in samples, they contended with the immobilized conjugates on the strip to bind with the mAb nanoparticles and produced distinct color patterns in the test zones. The limits of detection of the assay for GLY and SA were both 3.13 μg/mL. The capability of the LFA was substantiated using plant samples and Daiokanzoto, and its alignment with indirect competitive ELISA results was confirmed.ConclusionThe introduced LFA is a groundbreaking procedure that offers a rapid, straightforward, and sensitive method for simultaneously detecting GLY and SA in Daiokanzoto samples. It is instrumental in ensuring product quality.
Nondestructive discrimination of Potentilla anserina L. from different production areas based on near‐infrared spectroscopy
Authors: Ma Xiaobo , Hai Ping , Zhang Mengqi , Tian Mengyin , Zhang Wei , Li Lian , Zang Hengchang 
Published: January 2024

AbstractIntroductionThe traditional Chinese medicine (TCM) Potentilla anserina L. can use both as food and medicine. At present, the market mainly depends on experience to identify the species and determine the production areas of P. anserina. To ensure the quality of P. anserina, it is essential to improve the level of quality control.ObjectiveWe aimed to establish a rapid and nondestructive discrimination model to identify P. anserina from different production areas by near‐infrared spectroscopy.MethodsThe spectra of complete P. anserina medicinal materials and their powder of the same variety from four production areas were collected, and principal component analysis discriminant analysis and partial least squares discriminant analysis (PLS‐DA) were conducted based on different pretreatment methods and band selection methods. Then, the spectra of complete medicinal materials were converted into the spectra of medicinal powder for nondestructive identification.ResultsThe correct recognition rate (CRR) of the PLS‐DA discriminant model was the best after spectral preprocessing using autoscaling and competitive adaptive reweighted sampling for band selection. The CRRs of the calibration set and validation set were 100%, the CRRs of the external test set were 95%, 90%, 82%, and 88%, respectively, and the CRRs of the transfer external test set were 84%, 80%, 82%, and 86%, respectively.ConclusionWe realized the nondestructive and effective identification of P. anserina from different origins and laid a foundation for the industrialization and upgrading of TCM.
Rationality of the ethanol precipitation process in modern preparation production of Zishui‐Qinggan decoction evaluated by integrating UPLC‐QTOF‐MS/MS‐based chemical profiling/serum pharmacochemistry and network pharmacology
Authors: Wu Cheng‐Ying , Guo Yi‐Yin , Ma Zhen‐Yue , Zhou Jing , Long Fang , Shen Hong , Xu Jin‐Di , Zhou Shan‐Shan , Huo Jie‐Ge , Hu Can‐Hong , Li Song‐Lin 
Published: January 2024

AbstractIntroductionZishui‐Qinggan decoction (ZQD) is a classical traditional Chinese medicine formula (TCMF) for alleviating menopausal symptoms (MPS) induced by endocrine therapy in breast cancer patients. In the production of TCMF modern preparations, ethanol precipitation (EP) is a commonly but not fully verified refining process.ObjectivesChemical profiling/serum pharmacochemistry and network pharmacology approaches were integrated for exploring the rationality of the EP process in the production of ZQD modern preparations.Material and methodsUltra‐performance liquid chromatography–quadrupole time‐of‐flight tandem mass spectrometry (UPLC‐QTOF‐MS/MS) was applied to identify the chemical profiles and absorbed components of ZQD. Network pharmacology was used to identify targets and pathways related to MPS‐relieving efficacy.ResultsThe chemicals of ZQDs without/with EP process (referred to as ZQD‐W and ZQD‐W‐P, respectively) were qualitatively similar with 89 and 87 components identified, respectively, but their relative contents were different; 51 components were detectable in the serum of rats orally administered with ZQD‐W, whereas only 19 were detected in that administered with ZQD‐W‐P. Key targets, such as AKT1, and pathways, such as the PI3K‐Akt signalling pathway, affected by ZQD‐W and ZQD‐W‐P were similar, while the neuroactive ligand–receptor interaction pathway among others and the MAPK signalling pathway among others were specific pathways affected by ZQD‐W and ZQD‐W‐P, respectively. The specifically absorbed components of ZQD‐W could combine its specific key targets.ConclusionThe EP process quantitatively altered the chemical profiles of ZQD, subsequently affected the absorbed components of ZQD, and then affected the key targets and pathways of ZQD for relieving MPS. The EP process might result in variation of the MPS‐relieving efficacy of ZQD, which deserves further in vivo verification.
Nonsuicidal self‐injury in elementary schools: School educators' knowledge and professional development needs
Authors: Simundic Amanda , Hove Lisa Van , Baetens Imke , Bloom Elana , Heath Nancy 
Published: January 2024

AbstractPrevious research suggests that nonsuicidal self‐injury (NSSI; the intentional destruction of bodily tissue without suicidal intent) occurs among elementary‐aged children. However, it remains unclear to what extent elementary school educators encounter NSSI among students and how they respond. Therefore, this study investigated cross‐national differences in Canadian and Belgian elementary school educators' knowledge of, and experience with NSSI among students. More specifically, elementary school educators' perceived reasons and supportive needs of students who engage in NSSI, as well as their own professional development needs, were explored. In total, 181 elementary school educators across Canada (n = 63) and Belgium (n = 118) were recruited through teacher association listservs and by school administrators who distributed the study information to school staff. Chi‐square tests revealed that Canadian elementary school educators had more often encountered NSSI among their students than Belgian educators, although Canadian and Belgian school educators' similarly reported feeling ill‐equipped to deal with NSSI among students. Thematic analyses revealed that educators believe elementary‐aged students engage in NSSI because of various intrapersonal (e.g., low self‐esteem) and interpersonal stressors (e.g., bullying). Moreover, the majority of educators would like professional development to more effectively respond to students. Implications for schools and future research are discussed.
Heat and Mass transport phenomenon on 3D MHD Jeffery Nano‐liquid past an exponentially stretchable sheet subject to Soret and Dufour effect: Optimal Solutions
Authors: Basha Hussain 
Published: January 2024

AbstractThe literature survey reveals that nano‐liquids are more efficient for heat and mass transport in association with liquids traditionally. However, insight into established techniques for enhancing heat and mass transport in nano‐materials have filled the gaps. Subsequently, extensive research on the aforementioned model has become dynamic. The present investigation aims to study Magnetohydrodynamics on three‐dimensional incompressible, non‐Newtonian Jeffrey nano‐fluid flow over a bidirectional stretchable surface with slip velocities, convective, and mass fluxed zero conditions. Additionally, the impact of Soret and Dufour effects, along with the rate of the first‐order chemically reacted parameter, are taken into consideration. The dimensional equations are transformed into non‐dimensional ones by adopting the Optimal Homotopy Analysis Method (OHAM) to solve highly coupled non‐linear equations semi‐analytically. The results are represented graphically and listed numerically. The current research reveals a significant finding, the higher Deborah numbers amplify the horizontal velocity gradient, while reducing the Jeffery fluid parameter has a similar effect. Moreover, both the Jeffery fluid parameter and Deborah number contribute to the increase in thermal boundary layer thickness, which contrasts with the gradient of nano‐particle concentration. The obtained results are compared with the non‐availability of literature in the same direction by assuming some special cases on different gradients.
Vibration characteristics of FG saturated porous annular plates integrated by piezoelectric patches on visco‐Pasternak foundation
Authors: Allah Gholi Amir Masoud , Khorshidvand Ahmad Reza , Jabbari Mohsen , Khorsandijou S. Mahdi 
Published: January 2024

AbstractThe vibrational behavior of a three‐layered annular plate is considered in the present study. The plate is composed of a functionally graded (FG) porous core which is saturated by fluid and two piezoelectric patches that are bonded to the core and are subjected to the electric field. The whole of the structure is also rested on visco‐Pasternak elastic foundation. The material properties of the FG porous core vary through the thickness direction based on different patterns which are called porosity distributions. Love‐Kirchhoff's hypothesis and Hamilton's principle is employed to extract the governing motion equations and boundary conditions and following it, they are solved by generalized differential quadrature method (GDQM) for various boundary conditions. After ensuring the validity of the results by comparing them with known data in the literature, the effect of the most important parameters on the results is considered. It is seen that the effect of the porosity coefficient on the natural frequencies is completely dependent on the pores’ distribution patterns. Also, increasing in externally applied voltage to the piezoelectric facesheets, leads the results to enhance. The outcomes of this work can help to design and create smart structures and systems such as sensors and actuators.
Effect of carbon black and curing system on rubber–metal interface strength of automotive components
Authors: Drobilik Michal , Stenicka Martin , Poschl Marek , Zadrapa Petr , Stocek Radek 
Published: January 2024

AbstractRubber–metal parts inside the car require rubber compounds capable of ensuring optimal function and maximum service life without interface delamination. From this perspective, the strength of the bond which is created by the chemical interaction of rubber and metal by an adhesive is decisive for ensuring the functionality of the entire compound. It is dependent not only on the choice of the right adhesive but also on the rubber compound ingredients and their amount. Here, the influence of different types of carbon blacks as well as different curing systems in combination with a commonly used adhesive is described. The durability of the metal–adhesive–rubber bond is characterized by a specially designed shear strength analysis under quasi-static loading, whereas a significant influence of the structure of the carbon black has shown. It has also been observed that the presence of monosulphidic bonds has a positive effect on the shear strength.