bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building flexible data structure for disaster response
Authors: Wright Margaret S. 
Published: November 2023

AbstractContextRecent years have had repeated public health emergencies where communities are to take the lead in response. Yet official data systems rarely can support community decision‐making with real or near‐real time, localised data. This disconnect discourages evidence‐based decision‐making based on community need, leading instead to highly contested, and often erratic decisions.ObjectiveDevelop a plan for public health and communities together to develop, understand and use real (or near real) time data during a public health emergency, including roles and activities for public health, community decision‐makers and community members. Focus is primarily on communities without access to ‘in‐house’ dedicated data providers.DesignUsing ‘crisis standards of care’ and the National Planning Frameworks, a set of actions are proposed to build the data infrastructure for public health disaster response, focused on local data needs.ResultsThe proposed actions are organised within the ‘crisis standards of care’ five key elements framework. These actions are then connected to the Public Health Accreditations Board (PHAB) domains and the public health professionals core competencies demonstrating where these proposed actions fit in the services and skills of public health organizations and professionals. Many of the proposed actions would be applicable to larger more resourced communities and public health disaster responses.ConclusionsForward planning, practicing and discussions based in the ‘‘crisis standards of care’’ model and ‘The National Planning Frameworks’ could help communities build the relationships needed to access data for decision‐making in the moment. Further, using the ‘‘crisis standards of care’’ model would allow for development of a process and framework for rapidly shifting needs and resource access as is seen in emergencies. Model would also increase transparency and community focus, assisting decision‐makers in advocating and implementing the response in timely and equitable manner which would increase positive outcomes and positively engage the community.
Collagen Mimicry with a Short Collagen Model Peptide
Authors: Mukherjee Smriti , Sundarapandian Ashokraj , Ayyadurai Niraikulam , Shanmugam Ganesh 
Published: November 2023

AbstractMimicking triple helix and fibrillar network of collagen through collagen model peptide(CMP) with short GPO tripeptide repeats is a great challenge. Herein, a minimalistic CMP comprising only five GPO repeats [(GPO)5] is presented. This novel approach involves the fusion of ultrashort peptide with the synergetic power of π‐system and β‐sheet formation to short CMP (GPO)5. Accordingly, a hydrogel‐forming, fluorenylmethoxycarbonyl (Fmoc)‐functionalized ultrashort peptide (NFGAIL) is fused at the N‐terminus and phenylalanine at the C‐terminus of (GPO)5 (Fmoc‐NFGAIL‐(GPO)5‐F‐COOH, FmP‐5GPO). At room temperature, it forms a robust triple helix in aqueous buffer solution and has a relatively high melting point of 35 °C. The fluorenyl motif stabilizes the triple helix by aromatic π–π interactions as in its absence, triple helix is not formed. NFGAIL, which forms a β‐sheet, also aids in triple helix stabilization via intermolecular hydrogen bonding and hydrophobic interactions. FmP‐5GPO forms highly entangled nanofibrils with a micrometer length, which have excellent cell viability. The achievement of stable triple helix and fibrils in such a short CMP(FmP‐5GPO) sequence is a challenging feat, and its significance in CMP‐based biomaterials is undeniable. The present strategy highlights the potential for developing new CMP sequences through intelligent tuning of fusion peptides and GPO repeats.
A novel Bruton's tyrosine kinase inhibitor JDB175 shows potent efficacy to suppress central nervous system lymphoma
Authors: Xia Yong , Li Xue , Jiang Ning , Wei Xiawei 
Published: November 2023

AbstractPatients with central nervous system (CNS) lymphoma face limited treatment options and poor treatment outcomes, emphasizing the urgent need for effective therapeutic strategies. One limiting factor contributing to the suboptimal efficacy is the inadequate penetration of most treatment drugs across the blood–brain barrier (BBB). Recent insights into the pathophysiology of CNS lymphoma have identified the Bruton's tyrosine kinase (BTK) signaling pathway as a potential target. Some clinical trials have shown impressive responses to BTK inhibitors in CNS lymphoma. However, currently approved BTK inhibitors have low BBB penetration rates, limiting their efficacy. In this study, we discovered that JDB175, a novel and highly selective BTK inhibitor, exhibits excellent BBB penetration capabilities and demonstrates favorable activity in a mouse model of CNS lymphoma while showing no significant signs of toxicity. JDB175 effectively inhibits the BTK signaling pathway in human lymphoma cells, suppressing their proliferation, inducing cell cycle arrest, and promoting apoptosis. The significance of this study lies in addressing the critical unmet medical need for effective treatments for CNS lymphoma. This finding indicates a promising avenue for improved treatments in CNS lymphoma, potentially opening doors for further clinical investigation and therapeutic advancements.
Inelastic analysis of octagonal concrete‐filled steel tubular short columns under eccentric loading
Authors: Ahmed Mizan , Liang Qing Quan , Patel Vipulkumar Ishvarbhai , Hamoda Ahmed 
Published: November 2023

AbstractOctagonal concrete‐filled steel tubular (OCFST) columns combine the benefits of circular and square concrete‐filled steel tubular (CFST) columns so that they not only possess higher strength and ductility but also provide the ease of connection to composite beams. However, research studies have been very limited on the performance analysis of OCFST short beam‐columns subjected to eccentric loading. In this study, a fiber‐based numerical model is developed for the performance simulation of high‐strength OCFST short beam‐columns under eccentric loading. The simulation model takes into account material nonlinearities and concrete confinement induced by the octagonal steel tube. Computational methods are given that predict the axial load–moment interaction curves and moment–curvature responses of OCFST beam‐columns. The developed fiber model is verified against available test data with good accuracy. The influences of important parameters on the responses of high‐strength OCFST short beam‐columns are studied by means of utilizing the computational model. It is found that the behavior of OCFST beam‐columns is significantly influenced by the diameter‐to‐thickness ratio of the cross‐section, concrete strength, steel yield stress, and axial load ratio. Interaction equations are proposed for expressing the axial load–moment strength envelopes of the cross‐sections of OCFST beam‐columns and validated against numerical results.
Magnetized Baryonic layer and a novel BPS bound in the gauged-non-linear-sigma-model-Maxwell theory in (3+1)-dimensions through Hamilton-Jacobi equation
Authors: Canfora Fabrizio 
Published: November 2023

Abstract
It is show that one can derive a novel BPS bound for the gauged Non-Linear-Sigma-Model (NLSM) Maxwell theory in (3+1) dimensions which can actually be saturated. Such novel bound is constructed using Hamilton-Jacobi equation from classical mechanics. The configurations saturating the bound represent Hadronic layers possessing both Baryonic charge and magnetic flux. However, unlike what happens in the more common situations, the topological charge which appears naturally in the BPS bound is a non-linear function of the Baryonic charge. This BPS bound can be saturated when the surface area of the layer is quantized. The far-reaching implications of these results are discussed. In particular, we determine the exact relation between the magnetic flux and the Baryonic charge as well as the critical value of the Baryonic chemical potential beyond which these configurations become thermodynamically unstable.
Investigating the wear performance of AZ91D magnesium composites with ZnO, MnO, and TiO2 nanoparticles
Authors: Gnanavelbabu Annamalai , Vinothkumar Elayarasan , Ross Nimel Sworna , Prahadeeswaran Muthu 
Published: November 2023

AbstractIn recent decades, there has been a notable advancement in the field of bioactive, biodegradable, and biocompatible metallic materials, particularly for applications in general surgery. Among these materials, magnesium alloy-based composites have gained popularity due to their excellent biological properties and adequate strength. However, their resistance to wear is still an area that requires further investigation. Therefore, this study examines the wear properties of stir-ultrasonic-squeeze-casted magnesium (AZ91D) composites, incorporating distinct nanoparticles such as ZnO, MnO, and TiO2. The Evaluation-based Distance from Average Solution (EDAS) approach is used to determine the optimal parameters. Additionally, an Analysis of Variance (ANOVA) is conducted to identify the crucial factors influencing the responses. The effect of process factors on the wear rate and Coefficient of Friction (COF) is then investigated using response surface plots. The confirmation assessments reveal that the optimal parameter conditions for the tribo process comprise a 50.0018 N applied load, a 1.4998 m/s sliding velocity, and the AZ91D + 1% TiO2 (ATO) composite utilization. The ANOVA findings demonstrate that the applied load significantly contributes to 67.3% of the wear performance. Subsequently, after determining the optimal condition, it is observed that the ATO composite, when exposed to temperatures above 150 °C, exhibits an abrupt increase in wear rate and COF due to the degradation of grain strength and the dissolution of the β-phase within the composite.
Short stem hip arthroplasty with the optimys prosthesis is a safe and effective option for obese patients: a mid-term follow-up multicenter study
Authors: Hinz Nico , Marsoni Giulia , Mittelstädt Hagen , Sonnabend Falk , Wallroth Karsten , Johl Carsten , Weigert Ulrich , Anderl Conrad , Ortmaier Reinhold , Zeleny Natividad , Schulz Arndt-Peter 
Published: November 2023

Abstract
Introduction
Short stems are a valuable option in young patients undergoing total hip arthroplasty (THA) because of their bone stock preserving properties facilitating revision hip arthroplasty. Although the effect of obesity on conventional THA is well studied, data about short stem THA in obese patients are lacking. Therefore, this study aimed to investigate the influence of obesity on complications, revisions, and outcome after short stem THA.

Materials and methods
This multicenter, observational cohort study included patients undergoing short stem THA with the optimys prosthesis. Follow-up examinations were performed at specific intervals up to 7 years postoperatively. Operation characteristics, general and specific complications, revisions, VAS rest pain, VAS load pain, VAS patient satisfaction, and Harris Hip Score (HHS) were recorded and statistically compared between obese (BMI ≥ 30 kg/m2) and non-obese (BMI < 30 kg/m2) patients.

Results
Of the 224 patients included with a mean follow-up of 87.2 months (range 81.9–104.0), 69 were assigned to the OB group and 155 to the non-OB group. A minimally invasive approach was significantly less often selected in obese patients (p = 0.049), whereas operating time and length of hospital stay were not significantly different. The rate of general and specific complications did not significantly differ between both groups. Survival of the optimys prosthesis was 99.1% at 7-year follow-up and one patient per group had to undergo revision surgery. VAS rest pain, load pain, and satisfaction improved from preoperatively to postoperatively in both groups without a significant difference between both groups. While the HHS was improved from preoperatively to postoperatively, obese patients showed a significantly lower HHS at the 7-year follow-up (p = 0.01) but still exhibited an excellent scoring above the PASS threshold.

Conclusion
Short stem THA with the optimys prosthesis is a safe and effective option also in obese patients with an excellent clinical outcome and a low complication rate.
A new model for evaluating pressure-induced vascular tone in small cerebral arteries
Authors: Coccarelli Alberto , Pant Sanjay , Polydoros Ioannis , Harraz Osama F. 
Published: November 2023

AbstractThe capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological conditions. Here, we present a new computational model for quantifying the link, and its contributors, between luminal pressure and vascular tone generation in SCAs. This is assembled by combining a chemical sub-model, representing pressure-induced smooth muscle cell (SMC) signalling, with a mechanical sub-model for the tone generation and its transduction at tissue level. The devised model can accurately reproduce the impact of luminal pressure on different cytoplasmic components involved in myogenic signalling, both in the control case and when combined with some specific pharmacological interventions. Furthermore, the model is also able to capture and predict experimentally recorded pressure-outer diameter relationships obtained for vessels under control conditions, both in a Ca$$^{2+}$$

2
+

-free bath and under drug inhibition. The modularity of the proposed framework allows the integration of new components for the study of a broad range of processes involved in the vascular function.
Palbociclib sensitizes ER-positive breast cancer cells to fulvestrant by promoting the ubiquitin-mediated degradation of ER-α via SNHG17/Hippo-YAP axis
Authors: Lei Lei , Huang Yuan , Shi Lei , Ye Weiwu , Lv Xianmei , Ying Lisha , Yu Xingfei , Cheng Skye Hung-Chun , Zheng Yabing 
Published: November 2023

Abstract
Purpose
Endocrine therapy is the anti-tumor therapy for human breast cancer but endocrine resistance was a major burden. It has been reported that Palbociclib and fulvestrant can be used in combination for the treatment of patients who are experiencing endocrine resistance. However, the underlying mechanism is unclear. In this study, we aimed to investigate the mechanism by which Palbocicilib affected ER-positive breast cancer, combined with fulvestrant.

Methods
We first detected the effect of palbociclib on cell survival, growth and cycle distribution separately by MTT, colony formation and flow cytometry. Then SNHG17 was screened as palbociclib-targeted LncRNA by LncRNA-seq, and the SNHG17-targeted mRNAs were selected by mRNA-seq for further determination. Subsequently, the underlying mechanism by which palbociclib promoted the cytotoxicity of fulvestrant was confirmed by qRT-PCR, western blot, and immunoprecipitation. Eventually, the xenograft model and immunohistochemistry experiments were used to validate the sensitization effect of palbociclib on fulvestrant and its mechanism in vivo.

Results
Palbociclib significantly enhanced the cytotoxicity of fulvestrant in fulvestrant-resistant breast cancer cell lines. Interestingly, this might be related to the lncRNA SNHG17 and the Hippo signaling pathway. And our subsequent western blotting experiments confirmed that overexpressing SNHG17 induced the down-regulation of LATS1 and up-regulated YAP expression. Furthermore, we found that the increased sensitivity of breast cancer cells was closely associated with the LATS1-mediated degradation of ER-α. The following animal experiments also indicated that overexpressing SNHG17 obviously impaired the anti-cancer effect of co-treatment of palbociclib and fulvestrant accompanied by decreased LATS1 and increased ER-α levels.

Conclusion
Palbociclib might sensitize the cytotoxicity of fulvestrant in ER-positive breast cancer cells by down-regulating SNHG17 expression, and then resulted in the LATS1-inactivated oncogene YAP and LATS1-mediated degradation of ER-α.
Changes in the spatio-temporal genetic structure of Baltic sea trout (Salmo trutta L.) over two decades: direct and indirect effects of stocking
Authors: Burimski Oksana , Vasemägi Anti , Gross Riho 
Published: November 2023

AbstractSeveral countries have implemented stocking programmes to enhance abundance and fish production by releases of hatchery-reared fish. However, due to fluctuations in population size, stocking history, and potential indirect effects of straying of hatchery-reared fish, it is often difficult to predict how these factors will affect genetic diversity and differentiation patterns among wild populations. This study characterized the population genetic structure and temporal variability of four Estonian sea trout populations by evaluating the degrees of direct and indirect genetic impacts of stocking over two decades using 14 microsatellite loci. Our results demonstrate considerable temporal change combined with weak genetic structuring among studied sea trout populations. We found a reduction of the overall level of genetic differentiation combined with the tendency for increased genetic diversity, and an effective number of breeders (Nb) over the study period. Furthermore, we found that immigration rates (m) from hatchery stocks were highest in the population subjected to direct stocking and in non-stocked populations that were located geographically closer to the stocked rivers. This work suggests that hatchery releases have influenced the genetic diversity and structuring of studied sea trout populations. However, the impact of hatchery releases on the adaptive variation and fitness-related traits in wild trout populations remains to be revealed by more informative genetic markers. This study illustrates the dynamic nature of the population genetic structure of sea trout and the value of long-term genetic monitoring for management and conservation.
Harsh Parenting and Trajectories of Emotional and Behavioural Difficulties in Autistic Children
Authors: Cronshaw Georgia , Midouhas Emily 
Published: November 2023

Abstract
Autistic children show higher rates of co-occurring emotional and behavioural difficulties compared to other children in the general population. However, the environmental factors which contribute to the development of emotional (internalising) and behavioural (externalising) difficulties in autistic individuals are poorly understood. This study sought to investigate the association between harsh parenting (smacking, shouting, telling off) and the trajectories of emotional and behavioural difficulties in autistic children from ages 3 to 7. A sample comprising of 349 autistic children participated from the UK’s Millennium Cohort Study. Associations between harsh parenting and child emotional and behavioural difficulties were modelled using multilevel growth curve models. In autistic children, harsh parenting was associated with total emotional and behavioural difficulties and behavioural (but not emotional) problems concurrently. Moreover, harsh parenting was not associated with changes in emotional and behavioural difficulties over time. Harsh parenting may have an important role in externalising problems in young autistic children indicating the need for public health strategies which educate parents on its effects.
Racial Disparities in Family Income, Assets, and Liabilities: A Century After the 1921 Tulsa Massacre
Authors: Darity William A. , García Raffi E. , Russell Lauren , Zumaeta Jorge N. 
Published: November 2023

AbstractThis paper examines the financial health of racial-ethnic groups in Tulsa, Oklahoma, nearly a century after the 1921 Tulsa Massacre. We use data from the Tulsa National Asset Scorecard for Communities of Color (NASCC) survey to assess the financial health of two demographic groups that were historically the victims of racial violence - Native Americans and Black Americans. Specifically, we investigate financial outcomes a century after these groups made significant economic gains during the Tulsa oil boom in the early 1900 s and were subsequently victimized by racial violence. We find that Black households have statistically significantly less wealth and income than Whites in Tulsa. Our decomposition analysis shows household demographic differences between Blacks and Whites largely do not explain these wealth and income gaps, suggestive of historical discrimination. While in the case of the Native American tribes and Whites, the findings generally show no statistical significance. Compared to other NASCC-surveyed cities that did not experience destruction to the level of the Tulsa Massacre, the Black-White wealth and income gaps and the unexplained portion of the decompositions are the largest in Tulsa. Our results provisionally suggest that past exposure to racial violence can have long-term effects on the economic outcomes of the affected groups decades later.
Resilient Simultaneous Localization and Mapping Fusing Ultra Wide Band Range Measurements and Visual Odometry
Authors: Romanelli Fabrizio , Martinelli Francesco , Mattogno Simone 
Published: November 2023

AbstractIn this paper we consider a Simultaneous Localization and Mapping (SLAM) problem for a moving agent using Visual Odometry (VO) while measuring the range from a set of Ultra Wide Band (UWB) antennas, deployed in unknown position in the environment. The solution approach is based on a switching observer which, under standard working conditions, for each observed UWB, uses a two dimensional Extended Kalman Filter (EKF) providing an estimate of the range and bearing of the observed UWB with respect to the agent. This information is then used in a Robust EKF algorithm which solves the SLAM problem with performances that, even before closing the loop, are comparable to the ones that a VO algorithm (namely ORB-SLAM2) would obtain only after closing the loop. Moreover, a resilient module is added to the algorithm to evaluate the reliability of the position estimate of each observed UWB. When the Visual Odometry is not available, the switching observer uses an auxiliary EKF to provide an estimate of the agent position. This makes the proposed approach robust with respect to several kinds of unmodeled disturbances, like multipath effects, and automatically adapts to sensor failures with resilience (e.g. when Visual Odometry or UWB measurements are not available).