bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration
Authors: Yang Fan , Wang Hua , Guo Miao , Zhou Ziyan 
Published: December 2023

AbstractBackgroundOily skin is a common concern in the field of dermatology due to its association with excessive sebum production, acne, blackheads, and enlarged facial pores. Therefore, it is in great demand to develop effective cosmetics to manage oily skin.ObjectivesTo evaluate the clinical efficacy of a novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract for oily skin.MethodsThe efficacy of a novel emulsion was evaluated through a 56‐day clinical trial. The clinical efficacy of the product to ameliorate acne, blackheads, and conspicuous facial pores was assessed on 30 subjects with oily skin by VISIA, PRIMOS, professional dermatologist evaluations, and subject self‐assessment.ResultsIn the clinical trial, the participants showed high satisfaction with the emulsion's efficacy, reporting significant improvement in skin sebum secretion, acne, facial pores, and blackheads. The efficacy of the novel emulsion was further validated through VISIA and PRIMOS measurements, along with professional dermatologist evaluations.ConclusionOur results showed that the novel emulsion containing three active ingredients could effectively improve acne, blackheads, and conspicuous facial pores.
Sulfur speciation in Sphagnum peat moss modified by mutualistic interactions with cyanobacteria
Authors: Herndon Elizabeth , Richardson Jocelyn , Carrell Alyssa A. , Pierce Eric , Weston David 
Published: December 2023

Summary

Peat moss (Sphagnum spp.) develops mutualistic interactions with cyanobacteria by providing carbohydrates and S compounds in exchange for N‐rich compounds, potentially facilitating N inputs into peatlands. Here, we evaluate how colonization of Sphagnum angustifolium hyaline cells by Nostoc muscorum modifies S abundance and speciation at the scales of individual cells and across whole leaves.

For the first time, S K‐edge X‐ray Absorption Spectroscopy was used to identify bulk and micron‐scale S speciation across isolated cyanobacteria colonies, and in colonized and uncolonized leaves.

Uncolonized leaves contained primarily reduced organic S and oxidized sulfonate‐ and sulfate‐containing compounds. Increasing Nostoc colonization resulted in an enrichment of S and changes in speciation, with increases in sulfate relative to reduced S and sulfonate. At the scale of individual hyaline cells, colonized cells exhibited localized enrichment of reduced S surrounded by diffuse sulfonate, similar to observations of cyanobacteria colonies cultured in the absence of leaves.

We infer that colonization stimulates plant S uptake and the production of sulfate‐containing metabolites that are concentrated in stem tissues. Sulfate compounds that are produced in response to colonization become depleted in colonized cells where they may be converted into reduced S metabolites by cyanobacteria.
A novel miR160a–GmARF16–GmMYC2 module determines soybean salt tolerance and adaptation
Authors: Wang Chaofan , Li Xiaoming , Zhuang Yongbin , Sun Wancai , Cao Hongxiang , Xu Ran , Kong Fanjiang , Zhang Dajian 
Published: December 2023

Summary

Salt stress is a major challenge that has a negative impact on soybean growth and productivity. Therefore, it is important to understand the regulatory mechanism of salt response to ensure soybean yield under such conditions.

In this study, we identified and characterized a miR160a–GmARF16–GmMYC2 module and its regulation during the salt–stress response in soybean.

miR160a promotes salt tolerance by cleaving GmARF16 transcripts, members of the Auxin Response Factor (ARF) family, which negatively regulates salt tolerance. In turn, GmARF16 activates GmMYC2, encoding a bHLH transcription factor that reduces salinity tolerance by down‐regulating proline biosynthesis. Genomic analysis among wild and cultivated soybean accessions identified four distinct GmARF16 haplotypes. Among them, the GmARF16H3 haplotype is preferentially enriched in localities with relatively saline soils, suggesting GmARF16H3 was artificially selected to improve salt tolerance.

Our findings therefore provide insights into the molecular mechanisms underlying salt response in soybean and provide valuable genetic targets for the molecular breeding of salt tolerance.
A unique mutation in PIN‐FORMED1 and a genetic pathway for reduced sensitivity of Arabidopsis roots to N‐1‐naphthylphthalamic acid
Authors: Huang Minhua , Chen Jie , Yang Xinxing , Zheng Yanyan , Ma Yuan , Sun Kai , Han Ning , Bian Hongwu , Qiu Ting , Wang Junhui 
Published: December 2023

AbstractThe small chemical N‐1‐naphthylphthalamic acid (NPA) has long been used as a polar auxin transport inhibitor. Recent biochemical and structural investigations have revealed that this molecule competes with the auxin IAA (indole‐3‐acetic acid) inside the PIN‐FORMED auxin efflux carriers. However, the existence of any mutations in PIN family proteins capable of uncoupling the docking of IAA from NPA remains unclear. We report that Arabidopsis thaliana seedlings overexpressing SMALL AUXIN UP RNA 41 were hypersensitive to NPA‐induced root elongation inhibition. We mutagenized this line to improve the genetic screening efficiency for NPA hyposensitivity mutants. Using bulked segregation analysis and mapping‐by‐sequencing assessment of these mutants, we identified a core genetic pathway for NPA‐induced root elongation inhibition, including genes required for auxin biosynthesis, transportation, and signaling. To evaluate specific changes of auxin signaling activity in mutant roots before and after NPA treatment, the DR5::GFP/DR5::YFP markers were introduced and observed. Most importantly, we discovered a unique mutation in the PIN1 protein, substituting a proline residue with leucine at position 584, leading to a loss of NPA sensitivity while keeping the auxin efflux capacity. Transforming the null mutant pin1‐201 with the PIN1::PIN1P584L‐GFP fusion construct rescued the PIN1 function and provided NPA hyposensitivity. The proline residue is predicted to be adjacent to a hinge in the middle region of the ninth transmembrane helix of PIN1 and is conserved from moss to higher plants. Our work may bring new insights into the engineering of NPA‐resistant PINs for auxin biology studies.
The selection and preparation of red cell components for intrauterine transfusion: A national survey
Authors: Bodnar Melanie , Lieberman Lani , Arsenault Valerie , Berardi Philip , Duncan Jennifer , Lane Debra , Lavoie Marianne , McCarthy Joanna , Morrison Douglas , Robitaille Nancy , Shehata Nadine , Wilson Ann , Clarke Gwen ,   the Canadian Obstetrical and Pediatric Transfusion Network (COPTN)
Published: December 2023

AbstractBackground and ObjectivesThe practice regarding the selection and preparation of red blood cells (RBCs) for intrauterine transfusion (IUT) is variable reflecting historical practice and expert opinion rather than evidence‐based recommendations. The aim of this survey was to assess Canadian hospital blood bank practice with respect to red cell IUT.Materials and MethodsA survey was sent to nine hospital laboratories known to perform red cell IUT. Questions regarding component selection, processing, foetal pre‐transfusion testing, transfusion administration, documentation and traceability were assessed.ResultsThe median annual number of IUTs performed in Canada was 109 (interquartile range, 103–118). RBC selection criteria included allogeneic, Cytomegalovirus seronegative, irradiated, fresh units with most sites preferentially providing HbS negative, group O, RhD negative, Kell negative and units lacking the corresponding maternal antibody without extended matching to the maternal phenotype. Red cell processing varied with respect to target haematocrit, use of saline reconstitution (n = 4), use of an automated procedure for red cell concentration (n = 1) and incorporation of a wash step (n = 2). Foetal pre‐transfusion testing uniformly included haemoglobin measurement, but additional serologic testing varied. A variety of strategies were used to link the IUT event to the neonate post‐delivery, including the creation of a unique foetal blood bank identifier at three sites.ConclusionThis survey reviews current practice and highlights the need for standardized national guidelines regarding the selection and preparation of RBCs for IUT. This study has prompted a re‐examination of priorities for RBC selection for IUT and highlighted strategies for transfusion traceability in this unique setting.
Ex vivo biomechanical evaluation of an adhered fiberglass and polymethyl methacrylate sole‐hoof wall cast on stabilization of type III distal phalanx fractures under simulated physiologic midstance loads
Authors: Westman Shane , Cullen Thomas E. , Bergstrom Thomas C. , Edwards Lisa A. , Garcia Tanya C. , Stover Susan M. 
Published: December 2023

AbstractObjectiveTo evaluate the effect of the application of a novel fiberglass‐glue cast (FGC) on the fracture gap width in experimentally created type III distal phalanx fractures in cadaveric specimens under simulated physiologic loads.Study designEx vivo biomechanical laboratory study.AnimalsNine unilateral adult equine cadaver forelimbs.MethodsType III distal phalanx fractures were created in forelimb specimens, which maintained distal components of the passive stay apparatus. The fracture gap was measured at 5%, 20%, 25%, 50%, 75%, and 95% of fracture length (palmar articular border to solar margin) using D65Pr‐PaDiO radiographs. The limb was axially loaded (700, 3600, 4600, and 6700 N) before, during, and after removal of a woven fiberglass cloth and polymethyl methacrylate cast that encompassed the sole and distal portion of the hoof wall (FGC). Fracture gap widths were compared among loads and treatments using a mixed model ANOVA.ResultsOn average, under simulated physiological midstance loads, the fracture gap width was 0.2 mm smaller after FGC application, with the greatest decrease (0.5 mm) near the articular surface. On average, it was 0.3 mm smaller than after FGC removal. Fracture gap width was 0.1 mm greater when midstance loads transitioned from standing load to walking, trotting, and gallop loads. The fracture gap width increased by 1.3 mm with increasing distance from the articular surface.ConclusionThe FGC reduced the fracture gap width and prevented the fracture gap widening that occurred after FGC removal.Clinical significanceThe findings support consideration of FGC use in the treatment of horses with type III distal phalangeal fractures.
Use of real‐time near‐infrared fluorescence to assess gastric viability in dogs with gastric dilatation volvulus: A case‐control study
Authors: Mullen Kaitlyn M. , Regier Penny J. , Perez‐Rodriguez Veronica , Fox‐Alvarez W. Alexander , Bertran Judith , Colee James 
Published: December 2023

AbstractObjectiveTo describe near‐infrared fluorescence (NIRF) for assessment of gastric viability and describe NIRF's influence on the surgeon's operative strategy in dogs with gastric dilatation and volvulus (GDV).Study designProspective clinical trial.AnimalsTwenty dogs with GDV and 20 systemically healthy dogs.MethodsFollowing gastric derotation, the surgeon's subjective assessment of gastric viability was recorded prior to near‐infrared imaging. Changes in the surgeon's initial assessment of viability based on the visual pattern of gastric fluorescence was recorded. If nonviable (lack of defined vessels), a partial gastrectomy was performed and submitted for histopathology. The stapled gastrectomy line was imaged. Viable (defined vessels) and nonviable fluorescence intensities were compared with healthy dogs undergoing surgery for nongastrointestinal disease.ResultsSubjective assessment diagnosed 17 viable and three nonviable GDVs (2 fundi; 1 cardia). Near‐infrared imaging demonstrated nonviable gastric fluorescence in 4 dogs (3 fundi/cardia; 1 fundus). The surgeon's margins for resection were altered in 3/20 dogs. Fluorescence intensity (cardia, fundus, body, pylorus) was lower in GDV viable (30.59%, p = .04; 38.17%, p < .01; 51.18%, p < .01; 44.12%, p= .01) and nonviable (11.00%, p < .01; 4.33%, p < .01; 57.67%, p = .22; 54.33%, p = .72) dogs compared to healthy controls (44.7%, 70.05%, 84.00%, 63.95%). Fundic fluorescence was less in nonviable gastric tissue in comparison with viable gastric tissue (p = .03). Fluorescence of the gastrectomy staple line approximated that of viable tissue.ConclusionNear‐infrared fluorescence can identify histologically confirmed nonviable gastric tissue.Clinical significanceThese results provide enough evidence to support the implementation of NIRF as an adjunct to gross examination of the gastric wall in dogs with GDV.
Assessing Learning of Computer Programing Skills in the Age of Generative Artificial Intelligence
Authors: Wilson Sara Ellen , Nishimoto Matthew 
Published: December 2023

Abstract
Generative artificial intelligence (AI) tools such as ChatGPT, Bard, and Claude have recently become a concern in the delivery of engineering education. For courses focused on computer coding, such tools are capable for creating working computer code across a range of computer languages and computing platforms. In a course for mechanical engineers focused on C++ coding for the Arduino microcontroller and coding engineering problems in Matlab, a new approach to assessment of programing homework assignments was developed. This assessment moved the focus of assigned points from the correctness of the code to the effort and understanding of the code demonstrated by the student during in-person grading. Students who participated fully in in-person grading did significantly better on a midterm exam. Relative to a previous semester, where grading was focused on correct code, students had a slightly higher average midterm exam score. This approach appears to be effective in supporting computational learning in the face of evolving tools that could be used to circumvent learning. Future work should examine how to also encourage responsible use of generative AI in computational learning.
Acute appendicitis within an incisional hernia: a type of Amyand’s hernia
Authors: Pires Ines Oliveira , Tam Carolina , Moniz Luísa Cabral , Nascimento Carlos , Abrantes Marques Luis 
Published: December 2023

A man in his 60s presented to the emergency department with generalised abdominal pain and distention associated with the inability to pass stool or gas. The patient had undergone a laparoscopic partial right nephrectomy due to renal cell carcinoma a year ago. The workup diagnosis suggested an incarcerated incisional hernia. Surgical treatment was proposed. Intraoperatively, we found an ileocecal appendix with a macroscopically gangrenous appearance inside the hernia sac. An appendectomy was performed, and the hernia defect was closed using a tension repair. Amyand’s hernia, a rare condition, is classically described as an inguinal hernia containing the appendix, but it can also refer to an incisional hernia containing the appendix. Amyand’s hernia classification depends on the localisation of the hernia sac and its contents, including the presence or absence of appendix inflammation.This case report described a patient with Amyand’s hernia, which was diagnosed intraoperatively. The treatment was also discussed including open appendectomy and primary repair of the defect using a tension repair approach.
Probiotic Escherichia coli Nissle 1917 alleviates the neurotoxicity caused by acrylamide in zebrafish
Authors: Vajagathali M. , Hannah E. , Abirami K. , Tharanya M. , Jackson J.G. , Karthik R. , Aaron S.G. , Shanmugaraja M. 
Published: December 2023

Abstract
Neurotoxicity is caused by damage to the brain tissue by neurotoxic agents present in the environment and artificial substances produced by human beings. Acrylamide (ACR) is one such chemical substance that causes neurotoxicity, affecting the brain cells. This neurotoxicity causes damage to the sensory and metabolic functions. The current research investigates the favourable effect of probiotic EcN (Escherichia coli Nissle 1917) on ACR-induced neurotoxicity in zebrafish. The protective role of EcN against ACR induced toxicity was assessed based on behaviour, biochemical, and gene expression analysis. Initially, the colonisation period of EcN in the zebrafish gut was determined and EcN was given orally to the zebrafish only once prior to the ACR treatment. Very interestingly, this dosage was able to ameliorate the adverse effects of ACR significantly in the brain cells. Quantification of oxidative stress and neuronal cell death clearly vindicate the efficiency of probiotic EcN in reversing the damages caused by ACR. EcN is being explored largely in recent days for its therapeutic applications. This study strongly supports the view that EcN can be developed as a supplement to the patients diagnosed with neuronal cell toxicity.
A common edible insect (Antheraea assamensis) protein hydrolysate regulates LPS-induced oxidative stress and inflammation by modulating the TLR4/NF- κ β Signaling Pathway
Authors: Sahu R.K. , Borthakur S. , Saikia M. , Sarkar S. , Ahmed R.S. , Dasgupta D. , Dhakal R. , Mech S. , Manna P. , Dutta P. , Kalita J. 
Published: December 2023

Abstract
Dietary intake of antioxidant and anti-inflammatory-rich foods is a growing approach for fighting inflammation and its associated disorders. Edible insects are gaining popularity as a food source; however, their therapeutic properties, anti-inflammatory activity and their mechanism of action remain largely unexplored. Herein, we evaluate the effectiveness of Antheraea assamensis pupae hydrolysates against oxidative stress and inflammation. The proteins isolated from the pupae were digested with pepsin or pancreatin, or pepsin + pancreatin and passed through a 30 kDa molecular cut-off membrane. The low molecular weight protein hydrolysates were characterised using RP-HPLC, HRMS, XRD, and FTIR-ATR. Hydrolysate from pepsin + pancreatin digestion showed significantly higher DPPH (77.13±2.57%), superoxide (72.08±1.15%) and hydroxyl (56.32±0.90%) radical scavenging activity in a cell-free system. Further, it reduced intercellular ROS production and suppressed the lipopolysaccharide-induced protein expression of TLR4, p-IKKβ, p-NF-, IL-1β, and COX2 in RAW 264.7 macrophages. Furthermore, it inhibited the secretion of pro-inflammatory mediators, including IL-6, IL-1β, and MIP-2. These findings suggest that A. assamensis pupae hydrolysates can be a potential source of bioactive peptides for managing oxidative stress and inflammation.
A quasi-Bayesian Approach to Small Area Estimation Using Spatial Models
Authors: Li Jiacheng , Datta Gauri S. 
Published: December 2023

The empirical best linear unbiased prediction (EBLUP) method has been the dominant model-based approach in small area estimation. As an alternative to this frequentist method, the observed best prediction (OBP) method, also frequentist, was proposed by Jiang et al.[ 11 ] where the parameters of the model are estimated by minimizing an objective function which is implied by the total mean squared prediction error. In a recent article, Datta et al.[ 6 ] followed a general Bayesian approach, proposed recently by Bissiri et al.[ 2 ], to develop a quasi-Bayesian method by appropriately calibrating the objective function for the OBP method for the Fay-Herriot model. In a different article, Chung and Datta[ 4 ] demonstrated that in the absence of covariates with good predictive power the small area estimates from the standard Fay-Herriot model can be improved by using spatially dependent random effects. In this article, we develop a quasi-Bayesian small area estimation method using several spatial alternatives to the independent Fay-Herriot random effects model. Evaluation of the proposed method based on an application to estimation of four-person family median incomes for the U.S. states shows its usefulness. Limited but related simulation studies for the median incomes application reinforce our conclusion. AMS Subject Classification: 62F15, 62D99
The Impact of Training Based on the Pender Health Promotion Model on Self-Efficacy: A Systematic Review and Meta-Analysis
Authors: Jalali Amir , Ziapour Arash , Ezzati Ebrahim , Kazemi Shahrokh , Kazeminia Mohsen 
Published: December 2023

Objective The concept of self-efficacy is a determining factor in many behaviours related to health promotion and health education. Several pilot studies have been conducted in different parts of the world on different populations regarding the impact of training based on the Pender Health Promotion Model on self-efficacy, yielding conflicting results. Therefore, the present systematic review and meta-analysis were conducted with the aim of evaluating and summarizing the results of studies on the impact of training based on the Pender Health Promotion Model on self-efficacy. Data Source MagIran, SID, PubMed, Embase, Web of Science (WoS), Scopus and Google Scholar. Study Inclusion and Exclusion Criteria Original scientific research articles; Interventional studies; Studies investigating the effects of education based on the Pender Health Promotion Model on self-efficacy; Studies irrelevant to the objective; Cross-sectional studies; case reports; and papers presented in conferences; letters to the editor; systematic and meta-analysis studies. Data Extraction Two independent reviewers extracted data and assessed the quality of the 18 included studies using a pre-prepared checklist for the systematic review and meta-analysis process. Data Synthesis We conducted meta-analyses and reported the characteristics, outcomes, and risk of bias of studies. Methods The present study was conducted according to PRISMA guidelines until December 2022. The quality assessment of the included articles for meta-analysis was performed using the JBI checklist. Heterogeneity of the studies was calculated using the I 2 statistics, and Egger's regression intercept was used to assess publication bias. Results In the initial search, 13,943 studies were found, and after excluding studies irrelevant to the research objective, a total of 18 articles were included in the meta-analysis. These articles represented a sample size of 1015 individuals in the intervention group and 999 individuals in the control group. The combined results of the studies showed a significant increase in self-efficacy in the intervention group when compared to the control group (1.788 ± .267; CI: 95%, P < .001). With an increase in the year of study and the quality assessment score of the articles, the effect of the intervention decreased ( P < .001). Conclusion The results of this study indicated that training based on the Pender Health Promotion Model significantly increased self-efficacy. Therefore, it seems that training based on this model can have positive effects on individuals' self-efficacy.