bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Navigating through the digital swamp”: assessing SME propensity for online marketplaces
Authors: Gonçalves Marta P. V. , Ferreira Fernando A. F. , Dabić Marina , Ferreira João J. M. 
Published: October 2023

AbstractDigital technology has produced deep changes in the business world. However, companies have a hard time understanding consumers’ changing needs and new consumption patterns, especially small and medium-sized enterprises that currently face growing challenges in an era characterized by a lack of time and information overload. New mechanisms must be found that not only can keep businesses competitive in digital environments but can do so in innovative and sustainable ways. This study sought to address this issue by adopting a process-oriented approach and developing a decision-support tool for SMEs that are considering joining online marketplaces. The proposed analysis model helps these companies decide whether they are ready to take advantage of these digital platforms or whether they have to take action to improve in specific areas of their business operations. The model-building process relied on a combination of cognitive mapping and the best–worst method. An expert panel was recruited to identify the most relevant factors determining SME readiness to join online marketplaces. The model was applied to a set of real companies to assess their propensity for online marketplaces. The practical applicability of this decision-support system was then discussed in a consolidation session with a member of Portugal’s Agência Nacional de Inovação (National Innovation Agency), who acknowledged the strong potential of the proposed model.
Cheese Whey Permeate as a Precursor of Lactose-Free, Galactose-Rich Bioproducts: An Approach for Optimization and Application
Authors: Rivera Flores Viviana K. , DeMarsh Timothy A. , Fan Xingrui , Alcaine Samuel D. 
Published: October 2023

AbstractUnder specific conditions of oxygen availability and lactose hydrolysis, Brettanomyces claussenii OYL-201 can convert glucose in dairy coproducts into ethanol, leaving the galactose almost untouched. This approach could be applied specifically to whey permeate (WP) to develop foods with low-glycemic loads and other potential health benefits. The aims of this research are to optimize the fermentation of WP by B. claussenii, to maximize the production of ethanol and galactose, and to characterize various products obtained with this approach. For this purpose, five fermentation factors were studied to determine their impacts on ethanol and galactose: temperature (20–40 °C), substrate concentration (5–15%TS), lactase enzyme/substrate ratio (0–40 IU/ g lactose), inoculation level (6–8 log cfu/mL), and time (6–30 days). Linear models, containing quadratic and interaction effects, were built for the optimization of both responses. Optimal levels were predicted for the maximum outputs of ethanol and galactose simultaneously, which utilized the following parameters: 15%TS, 37 IU / g lactose, 28 °C, 7.5 log cfu/mL, and 30 days, which together were predicted to produce 4.0%v/v ethanol and 51 g/L galactose in the final product. These parameters were applied to 18-L fermentations, and the fermentates were processed via distillation and freeze-drying. As a result, four product streams were obtained: a fermented product with 3.4%v/v ethanol and 56 g/L galactose, a 45%v/v ethanol distillate, a galactose-rich drink base (63 g/L), and a galactose-rich powder (55%w/w). These results demonstrate that it is possible to maximize the production of ethanol and galactose from WP and to develop novel, potentially functional bioproducts from this stream.
Unbeabsichtigte Bildungswirkungen
Authors: Doll Daniel , Scherr Albert 
Published: October 2023

ZusammenfassungDie Offene Kinder- und Jugendarbeit (OKJA) positioniert sich in kritischer Distanz zu einem schulischen Bildungsauftrag, in dem sie u. a. Kinder und Jugendliche – und nicht Schüler_innen – adressiert. Gleichzeitig stellen Einrichtungen der OKJA Orte dar, an denen junge Menschen unabhängig von ihrer sozioökonomischen Verortung an Bildungsprozessen teilhaben können, indem sie u. a. die Möglichkeit zur eigenständigen Persönlichkeitsentwicklung erhalten. OKJA beansprucht damit, auch ein Bildungsort zu sein. Die Rolle der OKJA für Bildungsprozesse und die schulischen Bildungswege benachteiligter Jugendlicher ist jedoch weitgehend unerforscht. Der vorliegende Beitrag greift diese Forschungslücke auf und fokussiert darauf, was die OKJA aus der Perspektive ihrer Nutzer_innen zur Ermöglichung oder Behinderung von schulischen Bildungsprozessen beiträgt. Interviewt wurden Nutzer_innen der OKJA, die einen Schul- oder Berufsabschluss anstreben, der zum Studium berechtigt, deren Eltern aber keinen oder einen niedrigen bzw. in Deutschland nicht anerkannten Schul- oder Berufsabschluss haben und die deshalb Tätigkeiten ausüben, die keinen formalen Abschluss erfordern. Die Ergebnisse der verdeutlichen den Gebrauchswert, den Jugendliche der OKJA für ihre schulische Bildungskarrieren zuschreiben.
ZDHHC9: a promising therapeutic target for triple-negative breast cancer through immune modulation and immune checkpoint blockade resistance
Authors: Xu Chao , Xie Yongjie , Xie Peng , Li Jianming , Tong Zhongsheng , Yang Yanfang 
Published: October 2023

Abstract
Background
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor prognosis. This study aimed to identify potential therapeutic targets based on the expression profiles of differentially expressed genes (DEGs) in TNBC.

Methods
The Limma package was used to identify DEGs in TCGA and GEO datasets. Immunohistochemical (IHC) analysis and western blotting were used to determine the expression of ZDHHC9 in TNBC tissues. Flow cytometry assay and tissue immunofluorescence analysis were used to detect infiltration of multiple immune cells in tumor tissue at different levels of ZDHHC9 expression.

Results
ZDHHC9 was identified as a key factor associated with resistance to ICB therapy through weighted gene co-expression network analysis (WGCNA) and single-cell RNA sequencing (scRNA-seq). Subsequently, immunohistochemical (IHC) analysis and western blotting verified that ZDHHC9 expression was elevated in TNBC cancer tissues and that elevated expression of ZDHHC9 was associated with the poor survival of patients with TNBC. Analysis of data from several public datasets revealed that patients with high ZDHHC9 expression had an increased proportion of Ki-67 + breast cancer cells and tended to be basal-like breast cancer. In addition, in vitro and in vivo experiments demonstrated that high expression of ZDHHC9 significantly predicted the efficacy and responsiveness of immunotherapy in TNBC.

Conclusion
These findings suggest that ZDHHC9 is a valuable marker for guiding the classification, diagnosis and prognosis of TNBC and developing specific targeted therapies.
Mainstreaming nature-based solutions through five forms of scaling: Case of the Kiiminkijoki River basin, Finland
Authors: Sarkki Simo , Haanpää Olli , Heikkinen Hannu I. , Hiedanpää Juha , Kikuchi Karoliina , Räsänen Aleksi 
Published: October 2023

AbstractNature-based solutions (NBS) are considered as means to tackle climate change and biodiversity loss while simultaneously enhancing human well-being. Yet, it is still poorly understood how NBS could be mainstreamed. We address this gap by proposing a framework on NBS and employing it in Finland’s Kiiminkijoki River basin through participatory workshops and a questionnaire. We examine socio-environmental challenges and visions, existing and emerging NBS to reach the visions, and ways to scale-up NBS to a river basin level. In the river basin, water quality is the priority challenge, due to its relationships with local culture, climate change, and biodiversity. Our results consider how (1) to ensure the relevance of NBS for local actors, (2) instrumental, intrinsic, and relational value perspectives can be enhanced simultaneously by NBS, and (3) site specific NBS can be mainstreamed (i.e., by scaling up, down, out, in, deep) to the river basin level and beyond.
Targeting circulating tumor cells to prevent metastases
Authors: Gostomczyk Karol , Marsool Mohammed Dheyaa Marsool , Tayyab Hamnah , Pandey Anju , Borowczak Jędrzej , Macome Facundo , Chacon Jose , Dave Tirth , Maniewski Mateusz , Szylberg Łukasz 
Published: October 2023

AbstractCirculating tumor cells (CTCs) are cancer cells that detach from the primary tumor, enter the bloodstream or body fluids, and spread to other body parts, leading to metastasis. Their presence and characteristics have been linked to cancer progression and poor prognosis in different types of cancer. Analyzing CTCs can offer valuable information about tumors’ genetic and molecular diversity, which is crucial for personalized therapy. Epithelial-mesenchymal transition (EMT) and the reverse process, mesenchymal-epithelial transition (MET), play a significant role in generating and disseminating CTCs. Certain proteins, such as EpCAM, vimentin, CD44, and TGM2, are vital in regulating EMT and MET and could be potential targets for therapies to prevent metastasis and serve as detection markers. Several devices, methods, and protocols have been developed for detecting CTCs with various applications. CTCs interact with different components of the tumor microenvironment. The interactions between CTCs and tumor-associated macrophages promote local inflammation and allow the cancer cells to evade the immune system, facilitating their attachment and invasion of distant metastatic sites. Consequently, targeting and eliminating CTCs hold promise in preventing metastasis and improving patient outcomes. Various approaches are being explored to reduce the volume of CTCs. By investigating and discussing targeted therapies, new insights can be gained into their potential effectiveness in inhibiting the spread of CTCs and thereby reducing metastasis. The development of such treatments offers great potential for enhancing patient outcomes and halting disease progression.
Nurse Perceptions of Knowledge and Preparedness for Disasters
Authors: Küçük Uçar , Sari Canan , Demirbağ Birsel Canan 
Published: October 2023

Abstract

Objective:
The study aimed to determine the level of knowledge and perceptions of preparedness for disasters among nurses working in a tertiary university hospital.

Method:
The population of this cross-sectional study consisted of nurses working in a university hospital in the Eastern Black Sea Region of Turkey (n = 340). The sample included 183 nurses who were determined using the OpenEpi program and the universal sampling method. The data were collected using the Sociodemographic Information Form and the Disaster Preparedness Perception Scale in Nurses (DPPSN) and analyzed using SPSS 22 software.

Results:
The mean age of the participants was 34.31 + 8.52 years; 83.1% were female, 66.1% had at least a bachelor’s degree and worked in a surgical ward, 49.7% had been working for at least 11 years, and 58.5% had received training on disasters. Those who received disaster-related training received it mostly face to face (70.1%) from their institutions (91.6%) and in the form of 2–4 hours of training (75.7%); 52.5% had previously participated in a disaster-related drill, and 83.1% took on the role of caregiver during a disaster. The DPPSN mean score of the nurses involved in the study was found to be 3.53 ± 0.58 out of 5 points for the total scale.

Conclusion:
The results of the study showed that nurses considered themselves partially adequate for disaster preparedness, in general.
Deities’ Rights?
Authors: Das Acevedo Deepa 
Published: October 2023

AbstractA brief commotion arose during the hearings for one of twenty-first-century India’s most widely discussed legal disputes, when a dynamic young attorney suggested that deities, too, had constitutional rights. The suggestion was not absurd. Like a human being or a corporation, Hindu temple deities can participate in litigation, incur financial obligations, and own property. There was nothing to suggest, said the attorney, that the same deity who enjoyed many of the rights and obligations accorded to human persons could not also lay claim to some of their constitutional freedoms. The lone justice to consider this claim blandly and briefly observed that having specific legal rights did not perforce endow one with constitutional rights. Nevertheless, a handful of recent and high-profile disputes concerning Hindu temple deities and the growing influence of Hindu nationalist politics together suggest that the issue of deities’ rights is far from a settled matter. This article argues that declining to recognize deities’ constitutional rights accurately reflects dueling commitments in the Indian Constitution.
Importance of Bed Liquefaction‐Induced Erosion During the Winter Wind Storm in the Yellow River Delta, China
Authors: Niu Jianwei , Xie Jieshuo , Lin Shicheng , Lin Pengzhi , Gao Fei , Zhang Jian , Cai Shuqun 
Published: October 2023

AbstractData obtained during a 5‐month field observation of the Yellow River Delta show that the storm wave‐related oscillatory flows are mainly in an intermittently turbulent regime (400 < ReΔ < 1,200). Wave‐induced seabed liquefaction causes changes to the bed erodibility and increases the sediment entrainment rate, resulting in the formation of fluid mud layer (FML) during winter wind events. The strong NE winter winds lead to most of the wave‐induced liquefaction events in the study area. It was found the sediment erosion rate is underestimated when we solely focus on the wave‐induced bottom shear stress. To parameterize wave‐induced excess pore pressure buildup and sediment liquefaction, a series of experiments were conducted in a large wave flume and a new liquefaction‐erosion method is proposed to calculate the sediment erosion flux. Analysis of model results shows that the FML thickness is about 2–12 cm at the storm‐arrival stage during the entire observation period. The thickness of FML significantly increases with the increase of wave height and decrease of water depth. Once the FML is formed, strong currents can remove fluid mud 10 hr after the storm‐arrival stage, while the background currents on calm days can hardly cause suspension. The erosion rate in liquefaction zones can increase 5–10 times compared with the erosion rate in nonliquefaction conditions. The whole Bohai Sea is highly turbid after intense NE winter wind, and the liquefaction zones during winter winds would be the major sediment source. Enhanced sediment erosion can cause the subsequent degradation of the subaqueous Yellow River Delta.
Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology
Authors: Kuchling Joseph , Jurek Betty , Kents Mariya , Kreye Jakob , Geis Christian , Wickel Jonathan , Mueller Susanne , Koch Stefan Paul , Boehm-Sturm Philipp , Prüss Harald , Finke Carsten 
Published: October 2023

AbstractDecreased hippocampal connectivity and disruption of functional networks are established resting-state functional MRI (rs-fMRI) features that are associated with neuropsychiatric symptom severity in human anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. However, the underlying pathophysiology of NMDAR encephalitis remains poorly understood. Application of patient-derived monoclonal antibodies against the NR1 (GluN1) subunit of the NMDAR now allows for the translational investigation of functional connectivity in experimental murine NMDAR antibody disease models with neurodevelopmental disorders. Using rs-fMRI, we studied functional connectivity alterations in (1) adult C57BL/6 J mice that were intrathecally injected with a recombinant human NR1 antibody over 14 days (n = 10) and in (2) a newly established mouse model with in utero exposure to a human recombinant NR1 antibody (NR1-offspring) at the age of (2a) 8 weeks (n = 15) and (2b) 10 months (n = 14). Adult NR1-antibody injected mice showed impaired functional connectivity within the left hippocampus compared to controls, resembling impaired connectivity patterns observed in human NMDAR encephalitis patients. Similarly, NR1-offspring showed significantly reduced functional connectivity in the hippocampus after 8 weeks, and impaired connectivity in the hippocampus was likewise observed in NR1-offspring at the age of 10 months. We successfully reproduced functional connectivity changes within the hippocampus in different experimental murine systems that were previously observed in human NMDAR encephalitis patients. Translational application of this method within a combined imaging and histopathological framework will allow future experimental studies to identify the underlying biological mechanisms and may eventually facilitate non-invasive monitoring of disease activity and treatment responses in autoimmune encephalitis.
Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption
Authors: Geaney Alice , O’Reilly Paul , Maxwell Perry , James Jacqueline A. , McArt Darragh , Salto-Tellez Manuel 
Published: October 2023

AbstractDigital pathology (DP), or the digitization of pathology images, has transformed oncology research and cancer diagnostics. The application of artificial intelligence (AI) and other forms of machine learning (ML) to these images allows for better interpretation of morphology, improved quantitation of biomarkers, introduction of novel concepts to discovery and diagnostics (such as spatial distribution of cellular elements), and the promise of a new paradigm of cancer biomarkers. The application of AI to tissue analysis can take several conceptual approaches, within the domains of language modelling and image analysis, such as Deep Learning Convolutional Neural Networks, Multiple Instance Learning approaches, or the modelling of risk scores and their application to ML. The use of different approaches solves different problems within pathology workflows, including assistive applications for the detection and grading of tumours, quantification of biomarkers, and the delivery of established and new image-based biomarkers for treatment prediction and prognostic purposes. All these AI formats, applied to digital tissue images, are also beginning to transform our approach to clinical trials. In parallel, the novelty of DP/AI devices and the related computational science pipeline introduces new requirements for manufacturers to build into their design, development, regulatory and post-market processes, which may need to be taken into account when using AI applied to tissues in cancer discovery. Finally, DP/AI represents challenge to the way we accredit new diagnostic tools with clinical applicability, the understanding of which will allow cancer patients to have access to a new generation of complex biomarkers.
Assessment of the synthesis method of Fe3O4 nanocatalysts and its effectiveness in viscosity reduction and heavy oil upgrading
Authors: Torkaman Parya , Karimzadeh Ramin , Jafari Arezou 
Published: October 2023

AbstractIn this research, Fe3O4 nanocatalysts were synthesized systematically microwave-assisted. The effectiveness of the synthesized nanocatalysts in reducing viscosity and upgrading heavy oil was evaluated. The nanocatalysts were investigated for their magnetic and electromagnetic properties. The impact of microwave radiation's time and power on the size and purity of nanocatalysts was investigated. The purities in the crystal network of Fe3O4 nanocatalysts expanded as a result of reducing microwave radiation time and power due to less heat production. Increased temperature leads to dope NH4Cl into the Fe3O4 nanocatalysts crystal network. At: 1 min and power of 400 watts the most satisfactory results in the size and purity of nanocatalysts. The electromagnetic properties, size, and effectiveness of the synthesized Fe3O4 nanocatalysts have been examined to determine the effect of the synthesis method. The performance of Fe3O4 nanocatalysts synthesized by co-precipitation and microwave-assisted viscosity reduction and heavy oil upgrading was evaluated and compared. The crystallite size of the Fe3O4 nanocatalysts synthesized by microwave-assisted was smaller than that synthesized using co-precipitation. Fe3O4 nanocatalysts synthesized by microwave-assisted and the co-precipitation method decreased viscosity by 28% and 23%, respectively. Moreover, Fe3O4 nanocatalysts synthesized by microwave-assisted reduced the sulfoxide index and aromatic index considerably more than the co-precipitation synthesized Fe3O4 (90% against. 48% and 13% vs. 7%, respectively).
Sustainable development pathways for energies in Yangtze River Delta urban agglomeration
Authors: Xu Chao , Xie Da , Gu Chenghong , Zhao Pengfei , Wang Xitian , Wang Yanjia 
Published: October 2023

AbstractThe sustainable development of urban agglomerations plays a pivotal role in national and global efforts to reduce emissions. By focusing on the efficient exchange and optimization of energy consumption across various sectors, the sustainable development of energy systems within urban agglomerations can be achieved. However, the overall impact of the cross-sector energy optimization and complementarity has not been quantitatively analyzed. Here, we focused on the Yangtze River Delta (YRD) urban agglomeration in China and proposed an optimization framework for energy, environment, and economy. The framework considered four sectors: transportation sector, power sector, industry sector, and building sector, in order to determine the most sustainable development pathway for the urban agglomeration. The optimization model considers total costs and greenhouse gas emissions reduction as the objectives and utilizes technologies as constraints to optimize the pathway. We found that this optimization strategy resulted in a 53.1 billion tons increase in CO2 emissions reduction in the region. The results of emission reduction varied across sectors, ranging from 4.5 to 22.2 billion tons CO2 equivalent, and across cities, ranging from 7.1 to 4688.1 Mt. The results suggest that the core cities in the urban agglomeration can take on a leadership role. By promoting cross-sector collaboration and implementing energy recycling, the energy efficiency of surrounding cities can be greatly improved, leading to the sustainable development of the urban agglomeration.
Atomic structure of the Se-passivated GaAs(001) surface revisited
Authors: Ohtake Akihiro , Suga Takayuki , Goto Shunji , Nakagawa Daisuke , Nakamura Jun 
Published: October 2023

AbstractWe present a combined experimental and theoretical study of the Se-treated GaAs(001)-($$2\times 1$$

2
×
1

) surface. The ($$2\times 1$$

2
×
1

) structure with the two-fold coordinated Se atom at the outermost layer and the three-fold coordinated Se atom at the third layer was found to be energetically stable and agrees well with the experimental data from scanning tunneling microscopy, low energy electron diffraction, and x-ray photoelectron spectroscopy. This atomic geometry accounts for the improved stability of the Se-treated surface against the oxidation. The present result allows us to address a long-standing question on the structure of the Se-passivated GaAs surface, and will leads us to a more complete understanding of the physical origin of the electrical and chemical passivation of Se-treated GaAs surface.