bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells and Tissues
Authors: Patel Pinkal , Clark Abbot F. 
Published: January 2024

Abstract

Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of glaucoma, the leading cause of irreversible vision loss and blindness. An overall increase in resistance to aqueous humor outflow causes sustained elevation in IOP. Glaucomatous insults in the aqueous humor outflow pathway, including the trabecular meshwork (TM) precede such chronic physiological changes in IOP. These insults include ultrastructural changes with excessive extracellular matrix deposition and actin cytoskeletal reorganization that leads to pathological stiffening of the ocular tissues. One of the most common cytoskeletal changes associated with TM tissue stiffness in glaucoma is the increased prevalence of cross-linked actin networks (CLANs) in cells of the trabecular meshwork (TM) and lamina cribrosa (LC). In glaucomatous cells, rearrangement of linear actin stress fibers leads to formation of polygonal arrays within the cytoplasm, resembling a geodesic dome-like structure, that we identified as cross-linked actin networks (CLANs). In addition to increased amounts of CLANs in POAG TM cells and tissues, we also discovered that glucocorticoid (GC) and TGFb2 signaling pathways associated with the development of ocular hypertension (OHT) and glaucoma also induced CLANs in the TM. Despite a clear association, we are yet to completely understand the mechanisms involved in CLANs formation and their direct relevance to disease pathology. In this chapter, we will describe methods to identify and characterize CLANs using fluorescent microscopy in primary TM cell cultures, ex vivo perfusion cultured human anterior segments, and in situ in human donor eyes. Given the association of CLANs with glaucoma pathology (Fig. 1), it is important to determine the molecular mechanisms involved in CLAN formation and to discover new potential disease modifying therapies to better treat glaucomatous damage to the TM.
Temporal variability in air temperature lapse rates across the glacierised terrain of the Chandra basin, western Himalaya
Authors: Oulkar Sunil N. , Sharma Paramanand , Laha Sourav , Pratap Bhanu , Thamban Meloth 
Published: January 2024

Abstract

The air temperature lapse rate (TLR) is one of the essential parameters for glacio-hydrological studies. However, TLR estimations are limited in the glacierised regions of Himalaya due to a scarcity of long-term observations. Therefore, a dense in-situ monitoring network over a high Himalayan region is needed to estimate the TLR accurately. Here, in-situ air temperature data is obtained from Automatic Weather Stations (AWS) installed over the Chandra basin, western Himalaya, from October 2020 to September 2022. This data is used to estimate the TLR by regressing the air temperature with the corresponding elevations. We estimated the mean annual TLR of 3.8 ± 0.3°C km− 1 for the entire Chandra basin, significantly less than the standard environmental lapse rate (6.5°C km− 1). We found substantial seasonal variability in each TLR time series. The maximum TLR is 5.8 ± 0.2°C km− 1 during the summer, and the minimum is -1.6 ± 0.1°C km− 1 during winter, comparing all the meteorological stations. Further, we observe strong diurnal fluctuations of TLR, which has maximum and minimum values during 10:00 to 18:00 hrs and 20:00 to 09:00 hrs, respectively. The study highlights that the temporal variability of TLR is site-specific and strongly correlated with wind speed, relative humidity, and radiation fluxes. Furthermore, a temperature-index model is used to assess the implications of TLR by estimating glacier mass balance. This study highlights the importance of considering observed TLR to accurately model surface mass balance over the glacierised Himalayan region.
Predicting Pathological Complete Response After Neoadjuvant Chemotherapy in Breast Cancer by Clinicopathological Indicators and Ultrasound Parameters Using a Nomogram
Authors: Zhang Tingjian , Liu Yuyao , Tian Tian 
Published: January 2024

Abstract

Purpose
Explore the impact of pretreatment serum albumin-to-alkaline phosphatase ratio (AAPR) and changes in tumor blood supply on pathological complete response (pCR) in breast cancer(BC) patients following neoadjuvant chemotherapy (NACT). Additionally, establish and validate a nomogram for predicting pCR.
Methods
Included BC patients undergoing NACT at Yongchuan Hospital of Chongqing Medical University from January 2019 to October 2023. Analyzed the correlation between pCR and clinicopathological factors, as well as tumor ultrasound features, using chi-square or Fisher's exact test. Developed and validated a nomogram predicting pCR based on regression analysis results.
Results
The study included 176 BC patients, with 38.64% achieving pCR after NACT. Logistic regression analysis identified AAPR [odds ratio (OR): 2.616, 95% confidence interval (CI): 1.140–5.998, P = 0.023], changes in tumor blood supply after two NACT cycles (OR: 2.247, 95%CI: 1.071–4.716, P = 0.032), tumor histological grade (OR: 3.843, 95%CI: 1.286–10.659, P = 0.010), and HER2 status (OR: 2.776, 95%CI: 1.057–7.240, P = 0.038) as independent predictors of pCR after NACT. The nomogram, based on AAPR, changes in tumor blood supply after two NACT cycles, tumor histological grade, and HER2 status, demonstrated a good predictive capability.
Conclusion
AAPR, changes in tumor blood supply after two NACT cycles, tumor histological grade, and HER2 status independently predicted pCR in BC patients following NACT. The nomogram, based on these positive factors, demonstrated a good predictive ability.
All-optical in vivo photoacoustic tomography by adaptive multilayer acoustic backpropagation
Authors: Yoon Taeil , Ko Hakseok , Im Jeongmyo , Chung Euiheon , Choi Wonshik , Lee Byeong Ha 
Published: January 2024

Abstract
Photoacoustic imaging offers both high optical contrast and substantial imaging depth, serving as a robust tool for diverse biological and medical applications. While piezoelectric ultrasound transducers have traditionally been employed for acoustic pressure measurements and array-based configurations have enabled high-speed volumetric imaging. However, these approaches often require physical contact with the specimen under imaging and face limitations in spatial sampling bandwidth. To address these challenges, we present an all-optical photoacoustic imaging technique designed for high-resolution volumetric imaging of objects embedded within optically thick scattering media. Utilizing a soft cover layer and employing coherent averaging, our system enables optical profiling of nanometer-scale surface displacements caused by photoacoustic waves with subwavelength spatial sampling, even on complex and dynamically fluctuating biological surfaces. Furthermore, we introduce an adaptive multilayer acoustic backpropagation algorithm for high-resolution image reconstruction. This algorithm offers in situ adjustment of acoustic velocities across different media, compensating for the impedance mismatch between the tissue and the cover layer. The system achieves imaging up to a depth of 5 mm, with lateral and axial resolutions of 158 µm and 92 µm, respectively. We demonstrate in vivo volumetric imaging of the vasculature of a mouse's hindlimb as well as the blood vessels of a chicken embryo.
A Two-Eyed Seeing approach to describe Gumegwsis (Cyclopterus lumpus) ecology and fisheries interactions in the inner Mawipoqtapei (Chaleur Bay), Canada
Authors: No’gmaq M’sɨt , Ugpi’ganjig  , Gillis Carole-Anne , Chiasson Billie , Gagnon Catherine-Alexandra , Gosselin Pascale , Arsenault Lloyd , Vicaire John Murvin 
Published: January 2024

Abstract
The integration of diverse knowledge systems, encompassing Indigenous, local, and Western perspectives, is gaining traction in Canadian scientific research for coastal areas and fisheries. Despite proven successes, skepticism persists among scientists and decision-makers, leading to ineffective recovery measures for endangered aquatic species. Responding to concerns from Mi’gmaw fishers in Ugpi’ganjiq, the Gespe’gewa’gi Institute of Natural Understanding (GINU) initiated a collaborative project focused on the threatened Gumegwsis (Common lumpfish) in Chaleur Bay, Eastern Canada. Employing a Two-eyed seeing approach, the study combined interviews, mapping, and temperature monitoring, uncovering Gumegwsis life history, its significance to local fishers, behavioral changes, and critical spawning and nursery habitats. In contrast to prior assessments, which dismissed ceremonial and Aboriginal Traditional Knowledge (ATK) uses, our study highlighted the unique insights of Mi’gmaw fishers, emphasizing the importance of embracing diverse knowledge for species ecology and habitat understanding. This underscores the need for collaborative species recovery strategies, advocating for the co-creation of solutions and fostering cooperation in fisheries research.
DEVELOPMENT OF ZISWAF LABORATORY MODEL INTEGRATED MB-KM CURRICULUM USING ROWNTREE MODEL
Authors: Afrianty Noni , Setiawan Adi 
Published: January 2024

Abstrak: Penelitian ini bertujuan untuk melakukan pengembangan model laboratorium yang teirntegrasi dengan kurikulum MB-KM dengan menggunakan pendekatan Model Rowntree. Hasil penelitian ini menunjukkan bahwa pedoman yang dikembangkan sebagai petunjuk pelaksanaan PPL dan KKN MB-KM dikategorikan baik, sehingga dapat digunakan dalam pengembangan model laboratorium ZISWAF Fakultas EKonomi dan Bisnis Islam UIN Fatmawati Sukarno Bengkulu
Kata kunci: Model Laboratorium, Kurikulum MB-KM, Model Rowntree

Abstract: This study aims to develop a laboratory model that integrates with the MB-KM curriculum using the Rowntree Model approach. The results of this study show that the guidelines developed as guidelines for the implementation of PPL and KKN MB-KM are categorized as good, so that they can be used in the development of the ZISWAF laboratory model of the Faculty of Islamic Economy and Business UIN Fatmawati Sukarno Bengkulu
Keywords: Laboratory Model, MB-KM Curriculum, Rowntree Model
UNCOVERING THE RESEARCH LANDSCAPE OF ISLAMIC FINTECH: A BIBLIOMETRIC ANALYSIS
Authors: Sofyan Syaakir , Sofyan A. Syathir , Jalil Abdul , Rusanti Ega , Nuriatullah Nuriatullah , Nurfitriani Nurfitriani , Iftitah Iftitah 
Published: January 2024

Abstrak: Kajian mengenai Islamic fintech semakin berkembang seiring dengan kemajuan teknologi dan fintech. Tujuan dari kajian ini adalah untuk mengkaji tren perkembangan kajian Islamic fintech yang telah diterbitkan dalam jurnal yang terindeks Scopus dengan menggunakan kata kunci yaitu islamic fintech, islamic financial technology, sharia fintech, dan sharia financial technology. Analisis dilakukan terhadap karakteristik dan tren kata, serta abstrak, penulis, dan jurnal. Data yang dianalisis meliputi 95 artikel yang ditulis oleh 251 penulis dan terpublikasi dalam 56 jurnal. Metode analisis bibliometrik digunakan dengan menggunakan R Biblioshiny untuk menghasilkan peta bibliometrik. Hasil penelitian menunjukkan peningkatan signifikan dalam jumlah publikasi tentang Islamic fintech. Dalam analisis bibliometrik, ditemukan bahwa para penulis cenderung mengkaji isu-isu terkait pengguna Islamic fintech dengan menggunakan beberapa teori penerimaan aplikasi, sehingga pendekatan kuantitatif lebih dominan. Beberapa tema penelitian yang memiliki potensi untuk berkembang di masa depan meliputi isu pengguna, layanan keuangan sosial Islam, dan dampak terhadap performa dan pertumbuhan ekonomi. Penelitian ini memberikan kontribusi bagi penelitian masa depan serta memberikan pembaruan ilmiah dalam penilaian publikasi Islamic fintech yang memiliki pentingnya baik dari segi praktis maupun teoritis bagi kalangan akademisi.
Kata kunci: Bibliometrik, Tren penelitian, Teknologi keuangan Islam

Abstract: Studies on Islamic fintech are growing with advances in technology and fintech The purpose of this study is to examine the development trend of Islamic fintech studies that have been published in Scopus indexed journals using the keywords islamic fintech, islamic financial technology, sharia fintech, and sharia financial technology. The characteristics and trends of words, abstracts, authors, and journals were analyzed. The data analyzed included 95 articles written by 251 authors and published in 56 journals. The bibliometric analysis method was used in R Biblioshiny to produce bibliometric maps. The results indicate a significant increase in the number of publications on Islamic fintech. The results of the bibliometric analysis found that the authors tend to examine issues related to Islamic fintech users using several theories of application acceptance, so that the quantitative approach is more dominant. Several research themes that have the potential to develop in the future include user issues, Islamic social financial services, and their impact on economic performance and growth. This study contributes to future research and provides scientific updates in the assessment of Islamic fintech publications, which have both practical and theoretical importance for academics.
Keywords: Bibliometric, Research trend; Islamic fintech
Removal of nitrogen and phosphorous from blackwater via an integrated nature-based system: hybrid-vertical flow constructed wetland, upflow anaerobic fixed biofilm reactor, and granular activated charcoal column along with in situ electrochlorination disinfection
Authors: Gogoi Jayanta Kumar , Mutnuri Srikanth 
Published: January 2024

Abstract

The hybrid vertical-flow constructed wetland (H-VFCW) sequenced with an upflow anaerobic fixed biofilm reactor (UAFBR) was developed to treat blackwater for single households. The H-VFCW filter bed layer's redox zonation and hydraulic retention time (HRT) were designed optimally with the potential of simultaneous nitrification, denitrification, and enhanced biological phosphorous removal. The UAFBR optimisation for residual nitrate removal was based on the carbon -nitrogen ratio, HRT, and biofilm growth on carriers. Complete disinfection was achieved by optimised in situ electrochlorination by dosing 0.16% sodium chloride, with 20 min of electrolysis and 44.48 Am−2 of current density. The power consumption was 1.81±0.14 KWhm−3. Ammonia volatilisation was studied on a granular activated charcoal column (GACC) column to remove residual TAN as the final treatment. The integrated treatment system removed 98.63 ± 0.15% chemical oxygen demand (COD), 97.09 ± 0.19% total nitrogen (TN), 93.96 ± 0.34% nitrate (NO3−), 97.92 ± 0.2% TAN, 99.62 ± 1% orthophosphate (PO43−), 87.49 ± 0.36% total suspended solids (TSS), and 100% Coliform, with the final effluent pH of 8.4 ± 0.08. The microbial and functional annotation diversity of the UAFBR biofilm was studied. The treatment systems achieved the Central Pollution Control Board (India) effluent discharge standards.
Associations of Indoxyl Sulfate and p-cresyl Sulfate with Serum Uncarboxylated Matrix γ-carboxyglutamate Protein in Chronic Kidney Disease Patients
Authors: Tang Xiaofang , Liu Di , Xia Ming , Liu Yu , Liu Hong 
Published: January 2024

Background:
Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are two important
protein-bound uremic retention solutes. Increased serum levels of IS and PCS are associated
with cardiovascular calcification. Matrix γ-carboxyglutamate protein (MGP) is
a potent inhibitor of vascular calcification and inactivated uncarboxylated MGP (ucMGP)
is related to vascular calcification. Nevertheless, whether serum levels of IS and PCS
are associated with the serum ucMGP level in chronic kidney disease (CKD) patients
with different stages is unknown.

Methods:
This cross-sectional study enrolled 90 patients in different stages of chronic
kidney disease. Serum levels of IS and PCS were determined. The serum concentration
of ucMGP was measured with an enzyme-linked immunosorbent assay. Independent associations
between serum total IS and PCS with ucMGP were evaluated.

Results:
The mean serum level of ucMGP in participants of this study is 10.78 ±5.22
μg/mL. Serum levels of the two above-mentioned uremic toxins and ucMGP were elevated
commensurately with deteriorating renal function. The serum level of ucMPG was associated
with total IS (r = 0.456, p < 0.001) and total PCS (r =0.413, p < 0.001) levels.
Multiple linear regression analysis showed that ucMGP was significantly related to levels
of IS (β = 0.442, p <0.001), but not the level of PCS concentrations after adjusting
for other confounding variables.

Conclusion:
Our study showed that a higher serum IS level was independently associated
with ucMGP in deteriorating CKD. Therefore, it would be worthwhile to investigate
the effect of IS on ucMGP in the pathogenesis of vascular calcification in future studies.
CDK4 as a Prognostic Marker of Hepatocellular Carcinoma and CDK4 Inhibitors as Potential Therapeutics
Authors: Lai Fobao , Fang Yingbing , Cheng Cong , Zhong Xuejing , Zheng Wanrong , Lan Shiqian , Peng Quanshui , Cai Xiumei , Cao Tiantian , Zhong Chengqian , Gao Yuzhen 
Published: January 2024

Background:
The proteins CDK4 and CDK6, which are extremely homologous,
control cell cycle entry. For the treatment of breast tumors that include hormone receptors,
CDK4 and CDK6 inhibitors have been authorized. The link between CDK4 and
liver hepatocellular carcinoma (LIHC), however, has not yet been established.

Objective:
The study aimed to explore the link between CDK4 and LIHC and the effect
of CDK4 inhibitors on LIHC.

Methods:
In this study, we have evaluated CDK4's prognostic relevance in LIHC using
data from The Cancer Genome Atlas (TCGA). The relationship between clinical-pathologic
features and CDK4 expression has been evaluated using the Kruskal-Wallis test,
the Wilcoxon signed-rank test, and logistic regression. We have analyzed CDK4 and factors
related to the prognosis of HCC using the Kaplan-Meier technique and multivariate
Cox regression. Gene set enrichment analysis (GSEA) identified CDK4-related critical
pathways. To investigate the connections between CDK4 and cancer immune infiltrates,
TCGA data were employed in single-sample gene set enrichment analysis (ssGSEA).
For functional validation, CDK4 was chosen since it can be inhibited by recognized CDK4/
6-inhibitors (e.g., abemaciclib).

Results:
Poorer overall and disease-specific outcomes were linked to high CDK4 expression
in HCC patients. GSEA suggested that CDK4 and immune response are closely connected.
The amount of Th2 cells infiltrating was positively correlated with CDK4 expression,
while the amount of cytotoxic cells infiltrating was negatively correlated, according
to ssGSEA. Both in vitro and in vivo, the anti-tumor efficacy of CDK4 inhibitor has
been found to be superior to that of sorafenib.

Conclusion:
This study suggests a relationship between CDK4 and immune infiltration
and prognosis in HCC. Additionally, a CDK4 inhibitor may have anti-tumor properties
against hepatocellular cancer.
Screening for Biomarkers Related to Pigmentation and Formation in Vitiligo
Authors: Su Mengyun , Shi Ying 
Published: January 2024

Background:
Vitiligo is an autoimmune skin disorder primarily characterized by the
absence of melanocytes, leading to the development of white patches on the patient's skin. Narrowband
Ultraviolet B (NB-UVB) therapy is among the most effective approaches for stimulating
the reformation of hyperpigmentation. This treatment utilizes a narrow spectrum of NBUVB
wavelengths ranging from 311 to 313 nm to irradiate the affected area, thereby preventing
the destruction of migrating and proliferating melanocytes. Nevertheless, the molecular alterations
occurring in both the hair follicle and the interfollicular epidermis during NB-UVB
treatment remain unknown.

Methods:
In this study, we conducted a comprehensive analysis of the consistency of differentially
expressed genes (DEGs) within the enrichment pathways both before and after NB-UVB
treatment, utilizing a bioinformatics approach. Furthermore, we employed CYTOHUBBA and
Random Forest algorithms to identify and sequence hub genes from the pool of DEGs. Following
validation of these hub genes through ROC curve analysis, we proceeded to construct an
interaction network between these hub genes, miRNA, and drugs. Real-Time Quantitative Polymerase
Chain Reaction (RT-qPCR) was used to further verify the difference in the expression
of hub genes between the disease group and the control group.

Results:
Gene Set Enrichment Analysis of DEGs indicated strong associations with vitiligo in
most pathways. Subsequently, we conducted Gene Ontology and Metascape enrichment analyses
on the overlapping genes from DEGs. We identified key genes (COL11A1, IGFBP7,
LOX, NTRK2, SDC2, SEMA4D, and VEGFA) within the Protein-Protein Interaction (PPI)
network. We further explored potential drugs that could be used for the clinical treatment of
vitiligo through the drug-hub gene interaction network. Finally, the results of RT-qPCR experiments
demonstrated that the expression levels of the identified hub genes in both groups were
consistent with the bioinformatics analysis results.

Conclusion:
The hub genes obtained in this study may be a biomarker related to the development
of vitiligo pigmentation. Our research not only contributes to a better understanding of
the treatment mechanisms of vitiligo but also provides valuable insights for future personalized
medical approaches and targeted therapies for vitiligo.
A Comprehensive Review on Niosomes as a Strategy in Targeted Drug Delivery: Pharmaceutical, and Herbal Cosmetic Applications
Authors: Saharawat Sakshi , Verma Sushma 
Published: January 2024

:
Niosomes are newly developed, self-assembling sac-like transporters that deliver medication
at a specific site in a focused manner, increasing availability in the body and prolonging healing
effects. Niosome discovery has increased drugs’ therapeutic effectiveness while also reducing adverse
effects.

:
This article aims to concentrate on the increase in the worldwide utilization of niosomal formulation.
This overview presents a thorough perspective of niosomal investigation up until now, encompassing
categories and production techniques, their significance in pharmaceutical transportation, and cosmetic
use.

:
The thorough literature review revealed that extensive attention has been given to developing
nanocarriers for drug delivery as they hold immense endeavor to attain targeted delivery to the affected
area simultaneously shielding the adjacent healthy tissue. Many reviews and research papers have
been published that demonstrate the interest of scientists in niosomes. Phytoconstituents, which possess
antioxidant, antibiotic, anti-inflammatory, wound healing, anti-acne, and skin whitening properties,
are also encapsulated into niosome. Their flexibility allows for the incorporation of various therapeutic
agents, including small molecules, proteins, and peptides making them adaptable for different
types of drugs. Niosomes can be modified with ligands, enhancing their targeting capabilities.

:
A flexible drug delivery mechanism provided by non-ionic vesicles, which are self-assembling vesicular
nano-carriers created from hydrating non-ionic surfactant, cholesterol, or amphiphilic compounds
along comprehensive applications such as transdermal and brain-targeted delivery.