bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vibration analysis of dual rotor system equipped with active friction dampers based on harmonic balance method and sensitivity analysis
Authors: Jiang Minghong , Zhang Peng , Gao Xianghong , He Junxu , Zhu Changsheng 
Published: January 2024

Abstract
Numerical investigations are essential in appropriately determining normal forces for active dry friction dampers (ADFDs) within rotor systems, although existing methods suffer from the deficits of low-efficiency and over-simplifications. Within this paper, a harmonic-balance-based approach is proposed to efficiently obtain the responses of ADFDs-dual rotor system and a local sensitivity analysis is developed together with it to directly visualize the influences of ADFDs. The fixed-interface mode synthesis method and the trajectory tracing method are first utilized to reduce the system dimension. Then, a novel sampling strategy is proposed for the harmonic balance procedure to guarantee the orthogonality of Fourier basis. The resultant nonlinear equation is solved by the arclength continuation technique. To visually present the variation of rotor responses as the normal force of ADFD changes, a local sensitivity analysis method is developed together with the harmonic-balance-based solver. The frequency-domain sensitivity coefficients are derived analytically to facilitate computation of sensitivities. Numerical validations are carried to show the efficiency and accuracy of the developed method. The influences of ADFDs on rotor responses are discussed both numerically and experimentally. It is found that, due to the multiple excitations in dual rotor system, rotor whirl motions could exhibit the characteristics of multi-valued frequencies. The influences of ADFD on rotor responses are related to the rotational speeds, the ADFD normal forces and the ADFD installation positions. The developed method could intuitively show the influences of these factors on rotor vibration suppression, which provides an efficient tool for parameter optimization.
Transitioning Towards SysML v2 as a Variability Modeling Language
Authors: Epp Jordan , Robert Thomas , Ruch Olivier , Olechowski Alison 
Published: January 2024

Abstract

Systems engineers seek ways to reuse system models to accelerate the initial design development process on new complex projects. Despite its promise, one such solution -- the deployment of Model-based Product Line Engineering (MBPLE) -- presents challenges to practitioners. Not only is deployment costly, but an overwhelming number of variability modeling language options also lack interoperability. While research efforts work towards creating a universal variability modeling language and developing transformations between existing languages, this paper proposes incorporating variability modeling concepts into a system modeling language for a centralized management of product lines. In this work, we highlight SysML v2 as a promising language for variability modeling, arguing that it can orthogonally model systems and their variability. Further, we propose a novel metamodel that describes a SysML v2-based approach to modeling conceptual and asset variability spaces. We exemplify the deployment of this metamodel on a simple yet representative example found in a complex development environment. Since the SysML v2 specification is still in its early stages of standardization, this paper discusses how efforts in deploying MBPLE with existing approaches will translate to the new metamodel and includes considerations for transitioning from currently available commercial modeling tools to SysML v2. Ultimately, we hope the proposed metamodel will motivate SysML v2 tool vendors to support variability modeling by incorporating instantiation and constraint definition mechanisms and visualization capabilities in future tool releases.
The Northwestern Pacific corals unravel the NPGO/Victoria Mode-related temperature back to the 19th century
Authors: Ito Saori , Watanabe Takaaki K. , Yamazaki Atsuko , Shen Chuan-Chou , Watanabe Tsuyoshi 
Published: January 2024

Abstract

The atmospheric and oceanic phenomena in the Pacific Ocean, such as the North Pacific Gyre Oscillation (NPGO) and the Victoria Mode (VM), have significant implications for global climate change patterns. Although the relationship between surface temperature changes in the Central Pacific warming pool (CPW-ST), NPGO and VM has recently attracted attention, the historical relationships over the centuries remain unknown due to limited instrumental observations. Here, we present a long-term NPGO/VM-related temperature variability based on the Northwestern Pacific coral proxy from 1798 to 2014 AD. The coral skeletal Sr/Ca-inferred temperature record matched the CPW-ST time series, revealing extra-tropical propagation of NPGO/VM-related temperature variation from the central Pacific through an ocean-atmosphere bridge. Furthermore, we identified distinct negative NPGO/low-temperature phases in the late 1840s and during the 1860s-1900s and a positive NPGO/high-temperature phase in the 2000s-2010s. Additionally, a significant correlation between CPW-ST and high-frequency NPGO/VM variability was observed in the past 200 years. Our coral record indicates that the relationship lasted until the 1930s, except from the 1970s to the 1990s, and has strengthened from the 2000s to the present. The coral-based temperature record from the Northwestern Pacific provides important insights into the historical spatiotemporal changes in NPGO/VM-related temperature variability.
Urban Wastewater-based Surveillance of Sars-Cov-2 virus: A two-year study conducted in city of Patras, Greece
Authors: Anastopoulou Zoi , Kotsiri Zoi , Chorti-Tripsa Eleftheria , Fokas Rafail , Vantarakis Apostolos 
Published: January 2024

Abstract

Wastewater-based epidemiology, during the COVID-19 pandemic years, has been applied as a complementary approach, worldwide, for tracking SARS-CoV-2 virus into the community and used as an early warning of the prevalence of COVID-19 infection. The present study presents the results of the 2-year surveillance project, in the city of Patras, Greece. The purpose of the study was to monitor SARS-CoV-2 and implement WBE as an early warning method of monitoring Public Health impact. The presence of SARS-CoV-2, was determined and quantified in 310 samples using RT-qPCR assays. For the years 2022 and 2023, 93,5% and 78,7% of samples were found positive, respectively. Comparison of detection methods have been conducted to select the method with the highest recovery of the viral load. A seasonal variation of the virus was recorded, showing a recession in summer months confirming the country's epidemiological data as indicated by positive correlation of wastewater viral load with registered cases of COVID-19 infections during these years (p < 0.05) and moreover, sealed with a significant negative correlation observed with Daily Average (p < 0,01) and Daily Maximum Temperature (p < 0,01). More research was carried out to elucidate a possible association of physicochemical characteristics of wastewater with viral load showing positive correlation with Chlorides (p < 0,01) advocating possible increased use of chlorine-based disinfectants and Electrical Conductivity (p < 0,01) indicates that wastewater during periods of increased infections is more heavily loaded with ions from chemical and biological pollutants. No correlation found with rainfall and physicochemical indicators such as COD, BOD5, Total Phosphorus, Total Nitrogen and Total Suspended Solids. According to the findings, WBE represent a useful tool in the management of epidemics based on an environmental approach and it can also shed light on the interacting parameters that capture Public Health since any infections that may lead to epidemics lead to a parallel change in the use of pharmaceuticals, antimicrobials, disinfectants and microbial load in urban wastewater.
Oncolytic Virotherapy Combined with Nivolumab Elicits Complete Responses in Muscle-Invasive Bladder Cancer in Association with the Formation of Tertiary Lymphoid Structures
Authors: Li Roger , Villa Nancy , Yu Xiaoqing , Johnson Joseph , Borjas Gustavo , Dhillon Jasreman , Moran Carlos , Kim Youngchul , Francis Natasha , Dorman Denise , Powers John , Sexton Wade , Spiess Philippe , Poch Michael , Zemp Logan , Gilbert Scott , Zhang Jingsong , Pow-Sang Julio , Anderson Alexander , Li Tingyi , Wang Xuefeng , Grass G , Burke James , Dinney Colin , Rodriguez Paulo , Jain Rohit , Mulé James , Conejo-Garcia Jose 
Published: January 2024

Abstract

There is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-ineligible patients with muscle invasive bladder cancer. We launched a Phase 1b study using the combination of intravesical cretostimogene grenadenorepvec (oncolytic serotype 5 adenovirus encoding granulocyte-macrophage colony stimulating factor) with systemic nivolumab in cisplatin-ineligible patients with cT2-4aN0-1M0 muscle invasive bladder cancer. The primary objective was to measure safety and the secondary objective to assess the antitumor efficacy of the combination. No dose limiting toxicity was encountered in 21 patients enrolled and treated. Combination treatment achieved a pathologic complete response rate of 42.1%, which was associated with baseline free E2F activity and tumor mutational burden. Although T cell infiltration was broadly induced following intravesical oncolytic virotherapy, the formation and maturation of tertiary lymphoid structures was specifically associated with complete response, emphasizing the importance of adaptive humoral immune responses. Together, these results highlight the potential of this combination regimen to enhance therapeutic efficacy in cisplatin-ineligible patients with muscle invasive bladder cancer, warranting additional study as a neoadjuvant therapeutic option. ClinicalTrials.gov identifier: NCT04610671.
Species composition but not interspecific facilitation enhances zinc and selenium uptake in multispecies grasslands
Authors: Obasoro Omotola , Shackleton Jane , Grace Cornelia , Kennedy Jean , de Goede Ron , Hoffland Ellis 
Published: January 2024

Abstract
Aims
To understand the variations among grassland species in their ability to take up zinc (Zn) and selenium (Se) when cultivated as monocultures and to assess the effect of species richness on Zn and Se uptake. Additionally, to examine whether interspecific facilitation or species composition of the mixtures contributes to the potential increase in Zn and Se uptake in mixtures.
Methods
We conducted a grassland diversity experiment at both pot and field scales. In the greenhouse pot experiment, three grasses, four legumes and five forb species were grown as monocultures and mixtures along a species richness gradient. In the field experiment, we compared a monoculture of Lolium perenne sward with two multispecies mixtures (comprising grasses, legumes, and forbs). At harvest, Zn and Se uptake values were determined for all the monocultures and mixtures in both experiments.
Results
The capacity of the monoculture species to take up Zn and Se varied significantly in the pot experiment. Zinc and Se uptake increased with increasing species richness (P < 0.05). Higher Zn and Se uptake in the multispecies mixtures was primarily due to the large aboveground biomass production and/or high tissue Zn and Se concentration of some of the component species in the mixtures. However, there was insufficient evidence supporting interspecific facilitation.
Conclusion
To optimize Zn and Se uptake by multispecies mixtures, it is suggested that the choice of forage species should be based on biomass production potential as well as Zn and Se concentrations of the component species in the mixture.
Numerical study of flow in open-channel bends partially occupied with vegetation
Authors: ZHAO WENHAO , ZHANG SHENGTANG , ZHANG JINGZHOU , BILAL AHMER , LAN YUFEN , ZHANG LILI 
Published: January 2024

Abstract
Curved channel is a common topographic pattern in rivers. Its water flow characteristics have an important influence on the ecological environment of rivers and the construction of water conservation projects. In this work, five bending angles of the river at 0°, 45°, 90°, 135° and 180° are studied by Reynolds stress turbulence model. The simulation results showed that:(1)An increase in the bend angle of the river will reduce the flow velocity of the concave bank and increase the flow velocity of the convex bank.(2)When water flows through meandering rivers with vegetation on the concave bank, the main flow area gradually shifts from the convex bank to the boundary between non-vegetated and vegetated areas, and this shift velocity increases with the angle of curvature.(3)The turbulent kinetic energy of the vegetated region is much larger than that of the non-vegetated region, and the energy at the exit of the curve increases significantly.
Identification of the hydrogeochemical processes and assessment of groundwater quality using Water Quality Index (WQI) in semi-arid area F'kirina eastern Algeria
Authors: Khaldia Si Tayeb , Belgacem Houha , Miyada Ouanes , Vincent Valles , Abdelghani Elhoussaoui , Barbieri Maurizio , Boschett Tiziano 
Published: January 2024

Abstract

Groundwater is the primary source for human life, intended for consumption and agricultural production, particularly in the F'kirina plain, a semi-arid region in eastern Algeria. The study aims to determine the hydrogeochemical characteristics of groundwater, including (Ca2+, Mg2+, Na+, K+), CO3, HCO3−, Cl-, SO42−, NO3, PO4−, temperature, pH, electrical conductivity (EC), and total dissolved solids (TDS). The results were analyzed using XLSTAT software (2016) with Principal Component Analysis (PCA), Piper diagram, and four hydrochemical facies. Their suitability for human consumption was assessed by calculating the Water Quality Index (WQI) according to World Health Organization (WHO) standards (2011), with a WQI below 50 considered suitable for human consumption. Samples P3, P5, P6, and P15 were classified as excellent groundwater quality (WQI < 50), while samples P4, P7, P8, P9, P17, and P18 indicated good quality (50 < WQI < 100). However, 50% of the wells showed elevated levels of major elements exceeding the standards. The observed sequence of major element dominance is high quantities of Ca2 + > Mg2 + > Na + > K+, and the anions follow the order of Cl− > SO4 2 − HCO3 − > NO3 −> NO2 −. PCA results revealed two factors influencing overall hydrogeochemistry: geogenic impact attributed to the geological substrate and secondarily to prevailing geochemical (redox) conditions. Conversely, anthropogenic impact is primarily related to agricultural practices leading to nitrate enrichment and salinization. These factors contribute to groundwater quality degradation in f’kirina plain.
Assessment of soil liquefaction potential using genetic programming using a probability-based approach
Authors: Reddy Nerusupalli Dinesh Kumar , Gupta Ashok Kumar , Sahu Anil Kumar 
Published: January 2024

Abstract
Soil liquefaction is a substantial seismic hazard that endangers both human life and infrastructure. This research specifically examines the occurrence of soil liquefaction events in past earthquakes, with a special emphasis on the 1964 Niigata, Japan and 1964 Alaska, USA earthquakes. These occurrences were important achievements in the comprehension of harm caused by liquefaction. Geotechnical engineers often use in-situ experiments, such as the standard penetration test (SPT) to evaluate the likelihood of liquefaction. The attraction for this option arises from the difficulties connected in acquiring undisturbed samples of superior quality, as well as the related expenses. Geotechnical engineering specialists choose the deterministic framework for liquefaction assessment because of its clear mathematical approach and low needs for data, time, and effort. This work emphasises the need of integrating probabilistic and reliability methodologies into the design process of crucial life line structures to enable well-informed risk-based decision-making. The objective of this project is to create models that use deterministic, probabilistic, and reliability-based methods to evaluate the likelihood of soil liquefaction. The work presents a new equation that combines Bayes conditional probability with Genetic Programming (GP). and also in study is to identify the most suitable method for liquefaction analysis based on factor of safety and Performance Fitness Error Metrics (PFEMs), Rank analysis, Gini index, etc. The information provided in study data include soil and seismic characteristics, including the corrected blow count (N1)60cs, fines content (FC), mean grain size (D50), peak horizontal ground surface acceleration (amax), earthquake magnitude (M), and CSR7.5. The parameters are derived from the SPT measurements conducted at many global locations, together with field performance observations (LI) and probability of liquefaction has been assessed through the use of Gini Index (GI). A comparison was made between the novel methodology and the techniques proposed by Juang et al. (2002), Toprak et al. (1999), and Idriss and Boulanger (2006) status of case history data using Performance Fitness Error Metrices. The comparison included employing a confusion matrix for binary classification and doing a score analysis based on factor ranking. The proposed model exhibited superior performance, as the outputs of the constructed model increased for all positive factors and decreased for negative indicators.
Predicting long-term outcomes after primary PCI in Acute ST-segment elevation myocardial infarction patients with single-vessel disease
Authors: Yang Hai-tao , Liu Jing-Kun , Xie xiang 
Published: January 2024

Abstract
Background This study aimed to develop a predictive nomogram for long-term outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) for single-vessel disease, integrating the cholesterol-to-lymphocyte ratio (CLR) index with clinical data.Methods From April 2016 to December 2021, 1264 patients with acute STEMI were enrolled. They were divided into development (949 patients) and validation (315 patients) cohorts. Least Absolute Shrinkage and Selection Operator (LASSO) regression identified potential risk factors, and multivariate Cox regression determined independent risk factors for the nomogram. The model was transformed into a web-based calculator for ease of use. Its performance was evaluated using ROC curve analysis, calibration curves,and C-index. In addition, individual risk assessment based on the model is conducted.Results The nomogram included age, diabetes, heart rate, and CLR index as variables. In the development cohort, ROC analysis yielded AUCs of 0.816, 0.812, and 0.751 for predicting major adverse cardiac events (MACEs) at 2, 3, and 4 years, respectively. In the validation cohort, the AUCs were 0.852, 0.773, and 0.806. The C-index was 0.76 in the development cohort and 0.79 in the validation cohort. Kaplan-Meier analysis indicated a higher likelihood of MACEs in the high-risk group.Conclusions This predictive model, incorporating CLR index and electronic health record (EHR) data, reliably and accurately forecasts adverse cardiac events post-primary PCI in patients with acute STEMI and single-vessel disease, aiding in improved risk stratification and management.
Human decidual mesenchymal stem cells obtained from early pregnancy attenuate bleomycin-induced lung fibrosis by inhibiting inflammation and apoptosis
Authors: Ning Guangyao , Guo Xiaohui , Zhu Kechao , Cai Peian , Dang Yan , Lu Chen , Xu Feng , Shen Ruifang , Kang Ningning , Zhang Renquan , Chen Kegong 
Published: January 2024

Abstract
Background
Decidual mesenchymal stem cells (DMSCs) are easily obtained and exhibit strong anti-inflammatory and anti-apoptotic effects. Compared with bone marrow mesenchymal stem cells (BMSCs), their role in cell transplantation after idiopathic pulmonary fibrosis remains unclear.
Methods
BMSCs and DMSCs were derived from healthy donors. The anti-inflammatory and anti-apoptotic effects on both cell types were evaluated in vitro. The function of DMSCs in MLE-12 cells and mouse lung fibroblasts was examined using additional transwell coculture experiments in vitro. We investigated whether the transplantation of BMSCs and DMSCs could alleviate pulmonary inflammation and fibrosis in a bleomycin-induced mouse model of pulmonary fibrosis. Twenty-one days after MSC transplantation, we examined the inflammatory factors in the serum and bronchoalveolar lavage fluid, collagen content, pathology, fibrotic area, lung function, and micro-computed tomography of the lung tissue.
Results
DMSCs exhibited better anti-inflammatory and anti-apoptotic effects than BMSCs on MLE-12 cells in vitro. In addition, DMSCs inhibited tumor growth factor β-dependent epithelial-mesenchymal transition in MLE-12 cells and attenuated mouse lung fibroblasts fibrosis. Furthermore, transplantation of DMSCs in the mouse idiopathic pulmonary fibrosis model significantly attenuated pulmonary inflammation and lung fibrosis compared with BMSCs transplantation.
Conclusions
DMSCs exhibited better efficacy in improving pulmonary inflammation and lung fibrosis than BMSCs. Thus, DMSCs are a potential therapeutic target for pulmonary fibrosis.
Is double-J stent mandatory in complete supine percutaneous nephrolithotomy (csPCNL) for patients with staghorn renal stones?
Authors: Falahatkar Siavash , Esmaeili Samaneh , Kazemi Samira , Sheikhi Fatemeh , Norouzi Hosna 
Published: January 2024

Abstract
Background Two different stenting techniques including double-J (DJ) stent and external ureteral catheter (EUC) are commonly used to postoperative drainage in percutaneous nephrolithotomy (PCNL). We aimed to compared the effectiveness of DJ stent and EUC in tubeless complete supine PCNL (csPCNL) for patients with staghorn stones.Methods Between May 2007 and August 2023, a total of 124 patients who underwent tubeless csPCNL for their staghorn stones were enrolled in this analytical cross-sectional study. Patients were divided into two groups: Group 1 (DJ stent; n = 24) and group 2 (EUC; n = 100). Perioperative and postoperative parameters were compared in both groups.Results There were not significant differences in age, sex, body mass index, type of comorbidity disease, stone burden, previous kidney surgery, number of stones, hydronephrosis and anesthesia. The mean operative time of group 1 was significantly longer than group 2 (67.92 ± 28.58 and 55.25 ± 22.81, respectively). (P = 0.05) Although stone free rate in group 1 was higher than group 2 (79.2% vs. 66%); the difference did not consider statistically significant (P = 0.21). The length of hospital stay in group 2 was longer than another group (P = 0.04). The post-csPCNL complications were not significant different between 2 groups (P > 0.05). In group 1, more decreasing changes in serum creatinine after operation was observed. (P = 0.006)Conclusions The insertion of DJ stent has been identified as a safe and effective approach in csPCNL for reducing the duration of hospitalization and serum creatinine for patients with staghorn stones.