bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic microzonation studies in the Southern part of Progo River, special Region of Yogyakarta, Indonesia
Authors: Azifah Ghina Bani , Fathani Teuku Faisal , Setiawan Hendy 
Published: February 2025

Abstract

Background
There were more than 700 earthquakes with a magnitude of more than 5.0 over the past 100 years in the Special Region of Yogyakarta, Indonesia. Due to the high intensity of seismic activities, it is essential to perform seismic hazard analysis by considering local site effects. Therefore, this study aimed to analyze the peak ground acceleration (PGA) value based on the earthquake scenario of May 27, 2006, with a magnitude of 6.3, which occurred on the eastern side of the Opak Fault.

Methods
The study was conducted in the southern part of the Progo River, the Special Region of Yogyakarta, using 31 boreholes and 18 microtremor measurement points. The analysis was carried out using four methods: Kanai (In: Proceeding of Japan Earthquake Engineering Symposium 1–4, 1966) equation using microtremor data, deterministic equations with Ground Motion Prediction Equations Next Generations Attenuation West 2 (GMPE NGA West 2), Kanno et al (Bull Seismol Soc Am 96:879–897, 2006) attenuation equation, and probabilistic method referring to the Indonesian Seismic code.

Results
Results indicated that the highest value of PGA was obtained using the deterministic GMPE NGA West 2 weighted attenuation equation, which varied from 0.475 to 0.549 g. Meanwhile, Kanno et al (Bull Seismol Soc Am 96:879–897, 2006) attenuation equation resulted in values ranging from 0.266 to 0.394 g. In contrast, PGA values obtained through microtremor measurement resulted in a smaller value, in the range of 0.126–0.214 g. Probabilistic analysis in the study area produces values ranging from 0.373 to 0.450 g.

Conclusion
The location on the central side of the Progo River shows a lower PGA value than the other sides. PGA values will tend to be higher at locations near the earthquake source. The low PGA value that resulted from microtremor analysis was due to the consideration of local site effects in determining earthquake parameters in the study area. Determining the seismic hazard analysis method in infrastructure planning requires a comprehensive analysis by considering various parameters, such as the planning and design objectives, the location proximity to earthquake sources, historical seismic conditions, and the presence of the local site effects.
A case of post-traumatic anterior cranial dural arteriovenous fistula
Authors: Bhasme Vishal , Jain Divya , Bhirud Lomesh 
Published: February 2025

Abstract

Introduction
Dural arteriovenous fistula (dAVF) is an abnormal connection between an artery supplying the brain and vein or a venous sinus draining it. They account 10–15% of total arteriovenous malformations and are mostly idiopathic. Acquired cases include recurrent cerebral venous sinus thrombosis, head trauma, and past brain surgery.

Case report
A 41 years old admitted for severe headache, vomiting, and right-sided weakness. Patient had history of head trauma 3 years back. Radiology revealed left frontal hematoma with left anterior ethmoidal artery supplying a fistula and vein draining into left frontal parafalcine region with sac. Patient underwent craniotomy with clipping of dAVF without any major post-operative events.

Conclusion
Development of dAVF following trauma is rare. Our patient did not have any significant event in the past but developed dAVF as sequelae after 3 years. Anterior dAVF pose a challenge for endovascular embolization but clipping is straightforward.
Clinical characteristics and surgical outcomes in thoracic outlet syndrome: a comparative study of cases with and without cervical rib
Authors: Ali Amr N. , ElSobky Hesham , Abou El-Magd El-Sayed , Ibrahim Abdel Wahab Mahmoud 
Published: February 2025

Abstract

Background
Thoracic outlet syndrome (TOS) is a complex neurovascular condition caused by the compression of structures within the thoracic outlet. The presence of a cervical rib adds an additional layer of complexity, influencing the clinical presentation, progression, and outcomes. This study aims to evaluate the differences in clinical characteristics and treatment outcomes between patients with and without a cervical rib.

Methods
This prospective study was conducted over one year and included 19 patients diagnosed with symptomatic TOS. Patients were divided into two groups: group A (11 patients without cervical rib) and group B (8 patients with cervical rib). All patients underwent thorough clinical evaluation, including history taking, physical examination, imaging studies, and electrophysiological tests. Pain levels were assessed using a visual analog scale before and after operation as well as recording intraoperative data and postoperative complications.

Results
Patients with cervical ribs (group B) presented at a younger age (25.38 years of age in group B vs. 37.09 years of age in group A) were more likely to exhibit bilateral affection (37.5% in group B vs. 9.1% in group A) and exhibited more severe and rapidly progressing symptoms (The mean duration of symptoms in group B is 9.91 months vs. 27.5 months in group A.) compared to patients without cervical rib (group A). Surgical intervention in group B resulted in more rapid and complete symptom resolution with morbidity rates comparable to group A.

Conclusions
Cervical rib-associated TOS presents distinct challenges requiring tailored diagnostic and therapeutic approaches. Surgical management offers superior outcomes in this subgroup, emphasizing the importance of early diagnosis and intervention. Further studies with larger cohorts are needed to validate these findings and refine management guidelines.
Bycatch of common pollinators in pheromone baited traps for monitoring corn earworm (Lepidoptera: Noctuidae) in Missouri Industrial Hemp
Authors: Akotsen-Mensah Clement , Ativor Isaac N. , Foba Caroline N. , Babu Valliyodan 
Published: February 2025

Abstract

Background
Several traps are recommended for monitoring corn earworm, Helicoverpa zea (Boddie), an important pest of field, vegetable and fruit crops in the U.S. These traps, which are meant to capture H. zea in many cases end up capturing other insects. Helicoverpa zea has recently been found feeding on different seeds and dual-type (seed and fiber) hemp, Cannabis sativa L. (Rosales: Cannabaceae) causing serious damage. Limited work has been done on developing integrated pest management (IPM) for H. zea industrial hemp in Missouri.

Methods
We evaluated the attractiveness of different traps with the aim of developing a monitoring system for the adult male H. zea in industrial hemp fields in two Missouri locations. In addition, we recorded other non-target insects in the traps to determine trap selectivity. Commercially available green, clear, tricolor bucket traps Heliothis Scentry and Scentry Delta 1X traps baited with H. zea sex pheromones were evaluated in 2021 and 2022.

Results
Tricolor traps captured significantly more adult male H. zea than the other traps in both years. Non-target insects, mainly Xylocopa virginica (L.) (Hymenoptera: Apidae), Bombus spp. (Hymenoptera: Apidae), and Apis mellifera L. (Hymenoptera: Apidae) were also captured. The tricolor trap captured the most bees.

Conclusions
The presence of non-target species highlights the risk of using tricolor traps as a monitoring tool. This data provides information for planning the monitoring of corn earworm in industrial hemp farms in Missouri.
Sleep-administered ketamine/psychedelics: A streamlined strategy to address two challenges in research on ketamine and psychedelics
Authors: Arjmand Shokouh , Lindström Mats B. , Sellgren Carl M. , Wegener Gregers 
Published: February 2025

Abstract
The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.
Evaluation of Physicochemical, Microstructure Parameters (Q3) and Performance Attributes of Commercial Ketoprofen Gels
Authors: İşkin Şeyma , Kahraman Emine , Güngör Sevgi 
Published: February 2025

Abstract

In vitro methods for quality and equivalence assessment of semi-solid products applied to the skin have increasingly garnered attention because in vivo bioequivalence studies is high cost, complexity, and time-consuming. Regulatory authorities established draft guidelines that outline a modular framework demanding qualitative, quantitative, microstructure and product performance equivalence to support generic products. In line with these guidelines, our study aimed to evaluate the relationship between microstructure and performance attributes in both originator and generic semi-solid products applied to the skin. In this context, reference and three generics of ketoprofen gel were selected as models for semi-solid formulations. Microstructure of all products was assessed regarding pH, specific gravity, drying rate, formulation rheology and potential drug polymorphism. Additionally, performance attributes of products were evaluated using in vitro release testing and in vitro permeation testing. Polymorphism and drying rate data showed no significant difference in microstructure of ketoprofen gels. All tested products exhibited pseudo-plastic flow behavior with thixotropic characteristic. However, differences in pH, specific gravity and viscosity values at low shear stress were observed between reference product and generic products, according to EMA guidance. Although IVRT outcomes did not entirely align with Q3 attributes, IVRT results for reference product versus Generic Product-I and Generic Product-II met the acceptance limits according to FDA guidance, which differs from EMA's assessment. Furthermore, in vitro release rate results were consistent with IVPT data. Consequently, it can be concluded that microstructure of semi-solid products applied to the skin may not consistently correlate with performance attributes due to various alternations influenced by manufacturing process parameters and/or formulation components.

Graphical Abstract
Semaglutide Reprograms Macrophages via the GLP-1R/PPARG/ACSL1 Pathway to Suppress Papillary Thyroid Carcinoma Growth
Authors: Wang Longlong , Zhang Lele , Ma Runsheng , Zhang Yifei , Chang Qungang , Yin Detao 
Published: February 2025

Abstract

Context
The use of glucagon-like peptide-1 receptor (GLP-1R) agonists such as semaglutide, a novel class of antidiabetic medications, has raised concerns about potential adverse effects, particularly a possible association with thyroid cancer (TC).

Objective
This study aims to evaluate whether semaglutide influences the progression of TC by modulating tumor-associated macrophages (TAMs).

Methods
Semaglutide was administered to human papillary thyroid carcinoma (PTC) xenograft mouse models, coculture systems consisting of human THP-1 macrophage cells and PTC cells, and primary murine peritoneal macrophages. Assessments included tumor size, M1/M2 macrophage ratio, PTC cell proliferation, and polarization marker expression.

Results
Semaglutide did not significantly impact the proliferation of PTC cells but reduced tumor size and inhibited the proliferation of PTC cells in coculture systems. It increased M1 and decreased M2 macrophages, reprogramming polarization by downregulating PPARG expression. Cotreatment with semaglutide and a PPARG agonist in the coculture system confirmed the upregulation of downstream genes RSAD2, ACSL1, and PLA2G7. Silencing ACSL1 inhibited lipid accumulation in THP-1 cells and promoted polarization toward the M2 macrophage phenotype.

Conclusion
Semaglutide modulates macrophage lipid metabolism through the GLP-1R/PPARG/ACSL1 signaling pathway. This modulation promotes the conversion of TAMs to the M1 macrophage phenotype, enhancing their anticancer activity. These findings suggest that semaglutide may improve therapeutic strategies, reduce unnecessary thyroid nodule screenings, and broaden its clinical applications.
Overlapping Presentations and Diverse Genetic Defects Characterize Neuroendocrine Neoplasms in a Mexican Cohort
Authors: Hernández-Ramírez Laura C , Ramírez-Rentería Claudia , Rebollar-Vega Rosa G , Zuarth-Vázquez Julia M , Torres-Morán Mariana , Franco-Álvarez Alexa L , Manzo-Osnaya Andrea I , Martell-Jiménez Edgar , Rodríguez-Torres Maribel , Hernández-Núñez Wellbert E , Reza-Albarrán Alfredo A , Gamboa-Domínguez Armando , Espinosa-Cárdenas Etual , Sosa-Eroza Ernesto , Hernández-García Irma , González-Virla Baldomero , Hernández-Martínez Alex F , García-Sáenz Manuel , Eguiluz-Melendez Aldo , Mercado Moisés , Vargas-Ortega Guadalupe , Balcázar-Hernández Lourdes 
Published: February 2025

Abstract

Context
Genetic tests are part of the routine clinical approach to syndromic and nonsyndromic phenotypes of neuroendocrine neoplasms (NENs). Current data on phenotype–genotype associations in NENs, however, do not accurately represent all populations.

Objective
To describe the frequency, inventory, and clinical associations of germline defects associated with multiple types of NENs in a Mexican cohort.

Methods
Blood DNA from Mexican adults with NENs was analyzed with a 53-gene next-generation sequencing panel developed ad hoc (n = 90) or Sanger sequencing (n = 2). Single nucleotide variants, indels, and structural variants were identified, classified, and subjected to orthogonal confirmation. When possible, tumor samples and blood DNA from additional family members were tested using Sanger sequencing.

Results
Ninety-two probands (70.7% women, 51.5% sporadic) were included; 16 carried pathogenic or likely pathogenic (P/LP) variants and were significantly younger at disease onset than the rest (29.6 ± 10.7 vs 40 [21.5-51.5] years, P = .0384). Likely driving variants were identified in three-quarters of Von Hippel Lindau syndrome cases, one-third of multiple endocrine neoplasia (MEN) type 1, one-quarter of early-onset acromegaly/gigantism, and individual cases of Cushing's disease, MEN2A, and medullary thyroid carcinoma. One patient with clinical MEN1 associated with an SDHA variant and 1 with a pituitary tumor and neurofibromatosis type 1 were also identified. Probands with familial disease were more likely to carry P/LP variants than sporadic cases (26.7 vs 8.5%, P = .0282).

Conclusion
P/LP variants were identified in 17.4% of individuals with NENs. Our research provides a view of the landscape of NEN drivers in a population not previously characterized.
Intraoperative Endoluminal Pyloromyotomy Versus Stretching of the Pylorus for the Reduction of Delayed Gastric Emptying After Pylorus-Preserving Partial Pancreatoduodenectomy: A Blinded Randomized Controlled Trial (PORRIDGE Study; DRKS00013503)
Authors: Schrempf Matthias C. , Anthuber Matthias , Spatz Johann , Sommer Florian , Vlasenko Dmytro , Geissler Bernd , Wolf Sebastian , Schiele Stefan , Pinto David R. M. , Hoffmann Michael 
Published: February 2025

Abstract

Background
Pylorus-preserving partial pancreatoduodenectomy (ppPD) is a treatment for tumors of the pancreatic head. Delayed gastric emptying (DGE) is one of the most common complications following ppPD. In a retrospective analysis, intraoperative endoluminal pyloromyotomy (PM) was shown to be associated with a reduction in DGE rates.

Objective
The aim of this randomized controlled trial was to investigate the effect of intraoperative endoluminal PM on DGE after ppPD.

Methods
Patients undergoing ppPD were randomized intraoperatively to receive either PM or atraumatic stretching of the pylorus prior to creation of the duodenojejunostomy. The primary endpoint was the rate of DGE within 30 days after surgery.

Results
Sixty-four patients were randomly assigned to the PM group and 64 patients were assigned to the control group. There were no differences between the two groups regarding baseline characteristics. The DGE rate was 59.4% (76/126). In two patients (1.6%) DGE was not assessable. The most common DGE grade was A (51/126, 40.5%), followed by B (20/126, 15.9%) and C (5/126, 4.0%). The rate of DGE was 62.5% in the PM group versus 56.3% in the control group (odds ratio 1.41, 95% confidence interval 0.69–2.90; p = 0.34). The complication rate did not differ between both groups (p = 0.79) and there were no differences in quality of life on postoperative day 30.

Conclusions
Intraoperative endoluminal PM did not reduce the rate or severity of DGE after ppPD compared with atraumatic stretching of the pylorus.
Clinical efficacy and safety of P-15 peptide enhanced bone graft substitute in surgical bone regenerative procedures in adult maxillofacial, spine, and trauma patients
Authors: Spanninga Barend J. , Hoelen Thomáy-Claire A. , Johnson Scott , Cheng Boyle , Blokhuis Taco J. , Willems Paul C. , Arts Jacobus J. C. 
Published: February 2025

AimsAutologous bone graft (ABG) is considered the ‘gold standard’ among graft materials for bone regeneration. However, complications including limited availability, donor site morbidity, and deterioration of regenerative capacity over time have been reported. P-15 is a synthetic peptide that mimics the cell binding domain of Type-I collagen. This peptide stimulates new bone formation by enhancing osteogenic cell attachment, proliferation, and differentiation. The objective of this study was to conduct a systematic literature review to determine the clinical efficacy and safety of P-15 peptide in bone regeneration throughout the skeletal system.MethodsPubMed, Embase, Web of Science, and Cochrane Library were searched for relevant articles on 13 May 2023. The systematic review was reported according to the PRISMA guidelines. Two reviewers independently screened and assessed the identified articles. Quality assessment was conducted using the methodological index for non-randomized studies and the risk of bias assessment tool for randomized controlled trials.ResultsAfter screening, 28 articles were included and grouped by surgical indication, e.g. maxillofacial procedures (n = 18), spine (n = 9), and trauma (n = 1). Published results showed that P-15 peptide was effective in spinal fusion (n = 7) and maxillofacial (n = 11), with very few clinically relevant adverse events related to P-15 peptide.ConclusionThis systematic literature review concluded that moderate- (risk of bias, some concern: 50%) to high-quality (risk of bias, low: 46%) clinical evidence exists showing equivalent safety and efficacy in bone regeneration using a P-15 peptide enhanced bone graft substitute compared to ABG. P-15 peptide is safe and effective, resulting in rapid bone formation with a low probability of minor complications.Cite this article: Bone Joint Res 2025;14(2):77–92.
Enhancing Radiation Management in Passive Solar Greenhouses: Innovative Design Exploring the Synergy of Front Cover Geometry and Solid Top Roof
Authors: Mao Rui , Zhao Zilong , Lei Tian , Pan Wenjun , Wang Xinlei 
Published: February 2025

HighlightsNovel envelope design was developed for a typical passive solar greenhouse.Assessed the impacts of varied front roof slope and curve on regulating solar infiltration.Seasonal and latitudinal variations were considered in the model optimization.The solid and opaque design on the top roof has proved effective in avoiding overheating.ABSTRACT. The passive design of greenhouses is regarded as the key to solving the imbalanced space heating and cooling efficiency. Unfortunately, the lack of knowledge in their geometric variables—slope and curve of the outer envelope—prohibits the development of more energy-efficient greenhouses. This study proposes an innovative design for the greenhouse envelopes, including the front and top roofs, aiming at solving both the insufficient heating in winter and excessive heating in summer to ensure a passive and balanced energy environment. The overall geometry of the greenhouse, including the proposed steeper front roof and solid top roof design, is first introduced, followed by the mathematical model used for modeling the solar radiation and effective solar infiltration. Furthermore, a wide range of slope angles and curvatures at the slope for the greenhouse front roof are selected to be implemented in the model. By taking into account the varied latitudinal and seasonal factors, a comprehensive set of simulations is conducted to obtain the optimal slopes and curves at different set conditions. The top roof is also explored in a solid-finish design using a virtual case study simulated in Champaign, IL, USA. The independent and coupled impacts of slope and curve on the solar transmissivity and accumulation of solar radiation are evaluated and discussed. Non-negligible impacts were found in the design of the greenhouse envelope, as the optimal slope may impose up to 53% variation in winter and 93% in summer regarding the solar accumulation. The impact of curvature is found to be less significant, while it still influences the intake of solar radiation by approximately 10% in spring and summer in the simulated scenarios. The results obtained from this study may provide insights for the practitioners in the agricultural industry. Keywords: Design optimization, Passive greenhouse, Roof curvature, Roof slope, Solar radiation.
Preliminary Evaluation of Bio-Inspired Quasi-Static Mixers for In-Line Injection Systems
Authors: Liu Zhixin , Zhang Zhihong , Yuan Wen , Dai Junjie , Mao Jingyang 
Published: February 2025

HighlightsA bio-inspired quasi-static mixer mimic gastrointestinal peristalsis was designed.Image-based methods for assessing uniformity were performed.Consistently low variations confirmed the mixer's performance in mixture uniformity.Offers insights for enhancing mixer performance with bio-inspired approaches.Abstract. In precision agriculture, the in-line pesticide mixing system enhances conventional premixing methods by integrating a key component: the in-line mixer. This study introduces a novel bio-inspired quasi-static mixer designed to mimic gastrointestinal peristalsis, aimed at improving functionality. Utilizing the pixel-based coefficient of variation (CV) and histogram information entropy (HIE) for assessment, this research evaluates the performance of in-line mixers. Results demonstrate that the bio-inspired mixer consistently achieves CV values below 3.84%, obviously enhancing mixture uniformity. Specifically, it improves uniformity by an average of 34.09% for CV and 14.67% for HIE compared to conventional static mixers. These metrics effectively measure the uniformity levels of pesticide mixtures, indicating the superior performance of the bio-inspired mixer in achieving homogeneous mixtures under varied operational conditions. Furthermore, the study confirms the mixer's adaptability, showing notable performance improvements with increased flow rates and mixing ratios. This research validates the potential of bio-inspired design in enhancing the efficiency and efficacy of mixing systems and provides valuable insights for future mixer optimization to meet diverse agricultural needs. Keywords: Image processing, In-line detection, Mixture uniformity, Pesticide, Static mixer.