bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planning and Dosimetry Study of Dynamic Intensity-Modulated Radiotherapy and Volumetric-Modulated Arc Therapy for Carcinomas of the Pharynx Using 6MV Flattening Filter and Flattening Filter-free Beams
Authors: Rajadurai E , Saravana Kumar A. , Govindarajan KN , Pandu Bharath , Jacob Saro 
Published: February 2025

Abstract

Objective:
This study aims to methodically explore and evaluate the effectiveness of volumetric-modulated arc therapy (VMAT) and intensity modulated radiotherapy (IMRT) with both flattened and unflattened 6MV beams for treating pharyngeal carcinomas.

Materials and Methods:
Twenty patients who had previously undergone treatment for advanced pharyngeal cancer were randomly chosen. They were replanned using a fixed nine-field dynamic IMRT and VMAT with RapidArc using both 6MV flattened and unflattened beams. A total of 80 similar treatment plans were generated for the TrueBeam SVC setup. These plans were assessed for target coverage, maximum and mean doses to the organs at risk, monitor unit (MU), beam-on time, dose to healthy tissue, and other indicators of dose quality.

Results:
Target coverage was nearly identical across all the techniques. VMAT (6FF and 6FFF) achieved equivalent or superior target coverage while plans give better sparing of mean doses of parotid glands, esophagus, larynx, and maximum dose of the spinal cord while maintaining equivalent maximum dose of the brainstem. The MUs required for VMAT plans were about 4–5 times less than that of IMRT plans, additionally, the 6MV plan shows 20%–30% lesser MU than 6FFF plans in both techniques.

Conclusions:
VMAT-6FFF shows fewer hot spots in the planning target volume (PTV) high-risk volume and equivalent or higher hot spots in the PTV intermediate-risk and PTV low-risk volumes. In terms of treatment time, VMAT 6FF has fewer MUs than VMAT 6 FFF. Hence, it shows that VMAT 6FF has less treatment time.
Comparative Assessment for the Effect of Variable Chelating Agents on Dentin Microhardness: An In Vitro Study
Authors: Abdelhafeez Manal M. , AlWahbi Hajar T. 
Published: February 2025

ABSTRACT

Objective:
To evaluate the differential effects of various chelating agents on the microhardness of root canal dentin in an in vitro setting.

Materials and Methods:
This study utilized 36 single-rooted human premolars, divided into three groups (n
= 12 each), and treated with sodium hypochlorite followed by one of three chelating agents: chitosan, ethylenediaminetetraacetic acid (EDTA) with carbamide peroxide, and EDTA alone (Edita liquid). Vickers microhardness testing was conducted pre- and post-treatment to assess changes in dentin hardness.

Results:
All groups exhibited a decrease in microhardness, with the EDTA and carbamide peroxide combination showing the most substantial reduction. The mean microhardness decreased significantly from 44.59 HV to 39.00 HV in this group (P
< 0.001), while the chitosan group showed the least reduction, from 42.33 HV to 40.94 HV (P
= 0.001).

Conclusion:
Chelating agents significantly affect dentin microhardness; thus, their selection should consider both cleaning efficacy and potential impacts on tooth structure.
Genetic Markers as Predictors of Prognosis and Treatment Response in Patients with Oral Cancer: A Prospective Study
Authors: Mohammed P Rishal , Dash Mitali , Pati Seema , Yaqoob Ashfaq , Sanda Sailaja , Nelson Anish , Tiwari Heena D. 
Published: February 2025

ABSTRACT

Introduction:
“Oral squamous cell carcinoma (OSCC)” is a prevalent malignancy globally, with significant morbidity and mortality. Genetic markers are emerging as vital tools in predicting prognosis and treatment responses. This research explores genetic markers’ role in OSCC prognosis and therapeutic outcomes.

Methods:
This prospective research analyzed 150 OSCC patients, investigating the prognostic value of three genetic markers: TP53 mutations, miR-31 expression, and “mismatch repair (MMR)” protein loss.

Results:
Patients with TP53 mutations exhibited lower survival rates (P < 0.05). Elevated miR-31 was associated with aggressive disease (P < 0.01), while MMR loss correlated with advanced tumor stages (P < 0.001).

Conclusion:
Genetic markers, like TP53 mutations, miR-31, and MMR loss, can effectively predict prognosis and treatment responses in OSCC. Integrating these markers into clinical practice can enhance personalized treatment strategies.
Pediatric retinal detachments in eyes with extreme high myopia: Presenting features and final outcomes
Authors: Sindal Manavi D. , Behera Sourabh Prasad , Chaitanya Vivek 
Published: February 2025

Abstract
Extreme high myopia is associated with structural changes to the eye. The elongation of the eye, with associated choroidal thinning and macular atrophy, makes these eyes more susceptible to complex retinal detachments (RD). In this case series, we present the course of four pediatric cases with RD. All children had extreme myopia (−8.0 D to − 16.0 D). They presented with symptoms of squinting or abnormal pupillary reflex. Two had a choroidal detachment at presentation, whereas the other two had macular holes causing RD. All four required multiple surgical procedures, with anatomical success in three cases. Final visual acuity was no perception of light in all four eyes. Pediatric RD in extreme high myopia is challenging. Anatomical success needs multiple surgical procedures, but functional outcome remains dismal.
The conundrum of post-traumatic corneal rupture in a patient with Ehlers-Danlos syndrome
Authors: Jain Parul , Gupta Isha , Hariani Avani , Reddy Gahan 
Published: February 2025

Abstract
To describe the management of post-traumatic Descemet’s membrane detachment and intraoperative corneal rupture in a known case of Ehlers-Danlos Syndrome (EDS). A 7-year-old child, a known case of EDS, presented with Descemet’s membrane tear in the right eye for which intracameral sulfur hexafluoride (SF6) and descemetopexy were done. Intraoperative spontaneous rupture of the cornea was noted during descemetopexy which was managed using cyanoacrylate glue and bandage contact lens. We successfully used cyanoacrylate tissue adhesive glue for sealing of corneal rupture suggesting that it can be considered a treatment option for such cases where there is a lack of tissue strength for suturing.
An unusual case of corneal perforation secondary to Frontal Bone Mucormycosis
Authors: Anitha Venugopal , Velu Maneksha , Babu Senthil , Rajesh Arasi , Ravindran Meenakshi 
Published: February 2025

Abstract
We present the case of a 52-year-old male with a complex clinical presentation involving frontal sinus osteomyelitis (OM), mechanical ptosis, and extrusion of frontal bone sequestrum under the upper lid skin. He gave a history of chronic sinusitis, an uncontrolled diabetic for the past 2 years. The patient had a history of chronic sinusitis and poorly controlled diabetes for the past 2 years. Histopathological examination of excised sequestrum, stained with hematoxylin and eosin, confirmed a diagnosis of mucormycosis. Anterior segment examination revealed a corneal melt with a shallow anterior chamber. Initial management included the application of an amniotic membrane to promote epithelization. This is the first reported case of frontal bone OM leading to corneal melt, attributed to the mechanical erosion caused by the sequestered bone impinging on the corneal surface.
Hubungan Peran Teman Sebaya dan Kebiasaan Sarapan terhadap Perilaku Konsumsi Jajanan Anak di Sekolah Dasar MI Khadijah Malang
Authors: Kamila Wardah Chabibah , Handajani Sri , Miranti Mauren Gita , Lukitasari Febriani 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui 1) Hubungan peran teman sebaya terhadap perilaku konsumsi jajanan pada anak di sekolah dasar MI Khadijah Malang. 2) Hubungan kebiasaan sarapan terhadap perilaku konsumsi jajanan pada anak di sekolah dasar MI Khadijah Malang. 3) Hubungan peran teman sebaya dan kebiasaan sarapan terhadap perilaku konsumsi jajanan anak di sekolah MI Khadijah Malang. Penelitian ini menggunakan jenis penelitian korelasional dengan pendekatan kuantitatif. Data dikumpulkan melalui kuesioner yang diisi oleh 128 anak sekolah dasar MI Khadijah Malang. Teknik analisis data menggunakan serangkaian uji asumsi yaitu uji liniearitas dan uji normalitas, serta pengujian hipotesis menggunakan uji korelasi pearson. Hasil penelitian menunjukkan bahwa hubungan antara peran teman sebaya dan perilaku konsumsi jajanan ada taraf kekuatan tinggi dengan nilai signifikansi 0,000 (<0,05). Terdapat hubungan antara kebiasaan sarapan dan perilaku konsumsi jajanan dengan nilai signifikansi 0,009 (<0,05), serta peran teman sebaya dan kebiasaan sarapan memiliki hubungan yang signifikan terhadap variabel perilaku konsumsi jajanan dengan nilai signifikansi 0,000 (<0,05). Maka dapat disimpulkan bahwa 1) Terdapat hubungan peran teman sebaya terhadap perilaku konsumsi jajanan anak di sekolah dasar MI Khadijah Malang 2) Terdapat hubungan kebiasaan sarapan dengan perilaku konsumsi jajanan anak di sekolah dasar MI Khadijah Malang. 3) Terdapat hubungan peran teman sebaya dan kebiasaan sarapan terhadap perilaku konsumsi jajanan anak di sekolah dasar MI Khadijah Malang.
Perceptions of University Students on Green HRM Practices as Prospective Employees: The Mediating Role of Personality Attributes on Green Behaviors
Authors: Jeet Vikram , Qazi Sayeeduzzafar 
Published: February 2025

Objectives: The primary objective of the present research is to analyze the perceptions of university students on Green HRM practices as prospective employees and to highlight the mediating effect of their personality attributes on their green behaviors.

Theoretical framework: The research framework is based on a thorough literature review of relevant research studies, to link the relationship between GHRM practices, green behavior, and the influence of personality attributes.

Methods: The research employed an exploratory approach, utilizing primary data collection through a structured questionnaire. A total of 247 students have participated in the research. We have used SEM-PLS (SMART PLS-4 Version) and SPSS 28 for model construction, data analysis, and hypothesis testing.

Results: The results of the study support the positive influence of Green HRM practices on employees' pro-environmental behavior and attaining sustainable development goals. The direct effects of green involvement and green performance management significantly influence initiative-taking behavior, suggesting that these practices can motivate employees to engage in sustainable behaviors.

Research Implications: This study's results underscore the significance of adopting Green HRM methods and acknowledging individual personality traits in fostering pro-environmental behavior among workers in the workplace.

Originality value: The study offers valuable insights into the significance of mandating green behavior among students and aligning their personality attributes to foster a more sustainable business environment, thereby achieving the sustainable development goals.
The Impact of Diversification, CSR, and Capital Intensity on Tax Aggressiveness with Profitability as a Moderator in Achieving SDGs
Authors: Yanto Heri , Hajawiyah Ain , Baroroh Niswah , Pratiwi Resti Lintang 
Published: February 2025

Objective: This study aims to determine the effect of diversification strategy, Corporate Social Responsibility (CSR), and capital intensity on tax aggressiveness with profitability as a moderating variable in achieving SDGs.

Theoretical Framework: This study uses agency theory to analyze the research problems. While diversification fosters growth, shareholders struggle to monitor all operations, allowing management to adopt tax-aggressive practices to cut diversification costs, impacting company expenses.

Method: The population in this study is manufacturing companies listed on the Indonesia Stock Exchange (IDX) in the 2019-2022 period. The sampling in this study used a purposive sampling technique and obtained 51 companies with 204 total analysis units.

Results and Discussion: The results showed that diversification strategy and CSR variables have a negative effect on tax aggressiveness. Variable capital intensity does not affect tax aggressiveness. The profitability variables do not moderate diversification strategies, CSR, and capital intensity on tax aggressiveness.

Research Implications: These findings imply that diversification strategies and CSR can reduce tax aggressiveness, making them essential considerations for corporate strategy. For regulators, these results can serve as a basis for designing more effective tax policies. Future research can explore other influencing factors, such as corporate governance and financial transparency, that may have a more significant impact on tax aggressiveness.

Originality/Value: This study uses diversification strategy variables that are still rarely studied by researchers. The usage of profitability as a moderating variable is also a novelty of this study. This study support the SDGs no 16 - Peace, Justice, and Strong Institutions. This study highlights the importance of more effective tax policies to reduce aggressive tax reporting practices. The findings can serve as input for policymakers in creating a fairer and more transparent tax system, ultimately strengthening the country’s financial institutions.
Research Trends on the Impact of Corporate Social Responsibility on the Financialisation of Chinese Firms: a Systematic Review
Authors: Yingxiang Cheng , Teruki Neilson , Taasim Shairil Izwan Bin 
Published: February 2025

Objective: This review examines the impact of Corporate Social Responsibility (CSR) on the financialization of Chinese firms, a topic that has gained significant scholarly attention in the past five years amid China’s economic transformation.

Method: Through a systematic analysis of 12 studies (2000–2024) from databases such as CNKI, EBSCO, and Web of Science, the findings reveal a predominant focus on A-share listed firms, with most research utilizing post-2010 data.

Results and Discussion: CSR has emerged as a critical factor in shaping corporate financialization, reflecting its growing role in governance and strategic decision-making. However, the literature remains largely empirical, relying heavily on quantitative methods, and often excludes financially distressed firms, limiting generalizability.

Research Implications: The review highlights the need for theoretical development, sectoral diversification, and longitudinal studies to deepen understanding. It also underscores the importance of balancing CSR initiatives with sustainable financial practices, offering valuable insights for policymakers and corporate managers aiming to align financial strategies with long-term economic and social goals.
A percepção dos alunos de Medicina sobre ambientes de realidade simulada: Pacientes Virtuais
Authors: Silvestre V. A. , Gomes L. S. , Barroso C. R. D. , Santos R. T. , Utagawa C. Y. 
Published: February 2025

A imposição de uma realidade cada vez mais tecnológica torna inevitável repensar o ensino, buscando a inclusão de novos recursos na formação dos alunos. A utilização dos Pacientes Virtuais (PV) – ferramentas interativas desenvolvidas em computador que simulam situações clínicas em ambiente virtual – é uma alternativa para promover um contato mais direto dos alunos de Medicina com situações algumas vezes dificilmente vivenciadas durante o curso de graduação. O objetivo desta pesquisa é avaliar a percepção dos alunos do 1º ao 8º módulo do curso de Medicina do UniFOA, quanto à utilização dos PVs como ferramenta de aprendizagem e aperfeiçoamento da prática médica. A pesquisa foi realizada em duas etapas consecutivas, no mesmo dia e local, sendo cada módulo avaliado separadamente. Primeiro, os alunos acessavam a página do caso clínico e o resolviam (Electronic virtual patients – eVip). Em seguida, eram direcionados à página do questionário no Google Docs, onde o respondiam e finalizavam a tarefa. O questionário preservou a identidade dos alunos e foi estruturado em escala tipo Likert de 5 pontos para 10 afirmativas. Para análise dos dados obtidos foi calculado o Ranking Médio (RM), utilizando-se o método proposto por Malhotra (2001). Participaram 91 alunos, sendo 53F:38M, com a idade variando de 17 a 39 anos. Apenas 6,6% declararam conhecer PV. Em relação ao idioma, 18,7% dos alunos tiveram dificuldade de compreensão devido a língua inglesa. Quanto ao tempo para resolução do caso proposto, 58,2% dos alunos precisaram de 6 a 10 minutos. Para avaliar a percepção dos alunos sobre o PV, foi analisado o grau de interatividade de um PV, em que 58,2% dos alunos consideraram a plataforma com alto grau de interatividade e 37,4% com médio grau de interatividade. A simulação auxiliou no desenvolvimento de um raciocínio clínico correto pelo discente, tendo sido, em todos os períodos, considerado concordante. Os alunos também conseguiram reconhecer, no caso clínico, os dados da anamnese e do exame físico; estabeleceram hipótese diagnóstica e plano terapêutico para a doença e solicitaram exames complementares. Reconheceram a utilidade do PV para a aplicação dos conhecimentos aprendidos em sala de aula. Além disso, apesar de ser um ambiente virtual, verificou-se que o PV também contribuiu para demonstrar a relação médico-paciente para o sucesso do tratamento. Não houve diferença significativa das respostas entre o início da formação do discente com os anos subsequentes. Conclui-se, portanto, que os alunos reconheceram a utilidade da ferramenta em todos os anos dos períodos estudados, podendo contribuir para a formação do estudante de Medicina desde o início da vida acadêmica.
Câncer de pâncreas
Authors: Pereira J. A. C. , Koike L. V. , Almeida M. B. , Couto R. B. , Cezar V. F. G. , Soares I. C. 
Published: February 2025

O câncer de pâncreas é uma neoplasia de difícil diagnóstico precoce devido à escassez de sinais e sintomas na sua fase inicial. Com isso a maioria dos casos só são diagnosticados em estágios avançados da doença e tem como consequência uma alta taxa de mortalidade. É mais comum em idosos acima de 60 anos e possui maior incidência no sexo masculino. O adenocarcinoma ductal pancreático é o tipo mais comum, corresponde a 90% dos casos, e acomete principalmente a região da cabeça do pâncreas. Os fatores de risco mais consistentes são idade, tabagismo, diabetes mellitus, pancreatite crônica, além de fatores hereditários e ambientais. Os sintomas mais perceptíveis são fraqueza, perda ponderal, e icterícia se ocorrer obstrução do ducto colédoco. O presente trabalho relata o caso de um paciente de 77 anos, sexo feminino, que procurou atendimento ambulatorial há 2 meses, com quadro de diarreia. Apresentou icterícia, com piora progressiva há 1 mês, além de presença de colúria, acolia fecal, perda ponderal importante (+/- 17Kg nos últimos 3 meses). Refere ainda náusea e dor abdominal em epigástrio e hipocôndrio direito, sem fatores de melhora ou piora. Nega febre e prurido. Até o diagnóstico final, outras patologias foram apontadas como possíveis causadoras dos sinais os sintomas dessa paciente, como síndrome colestática e síndrome hepatocelular. Esses diagnósticos diferenciais foram descartados por meio da realização e correta avaliação de uma ultrassonografia de abdômen superior e uma tomografia computadorizada de abdômen. Por fim, foi realizada uma colangioressonância magnética que mostrou aumento da cabeça de pâncreas, levando ao diagnóstico final e à discussão de possíveis propostas terapêuticas.
Abdome Agudo Complicado por câncer de cólon ascendente perfurado
Authors: Fernandes A. C. , Arbex M. A. 
Published: February 2025

O abdome agudo (AA) diz respeito a uma alteração súbita, espontânea, atraumática e que provavelmente tem a necessidade de abordagem cirúrgica de urgência. O manejo clínico deve ser ordenado de acordo com a história objetivando-se excluir os possíveis diagnósticos diferenciais e, com isso, instituir o tratamento adequado de maneira mais eficiente. A dor abdominal é o principal sintoma do AA, sendo que podem estar associadas náuseas, vômitos, obstrução intestinal e/ou diarreia4. A perfuração de um segmento intestinal é uma complicação aguda e que necessita de tratamento, principalmente cirúrgico, de urgência, com potencial risco de vida do paciente . O câncer de cólon possui como fatores de risco o tabagismo e o consumo excessivo de álcool e sua incidência aumenta de acordo com o avanço da idade. O caso que iremos relatar trata-se de um paciente idoso que procurou o atendimento médico devido à dor abdominal em quadrante superior direito associada a um episódio de vômito; os exames laboratoriais e de imagem confirmaram o diagnóstico de abdome agudo e o paciente foi submetido à laparotomia exploradora onde se constatou o tumor de cólon ascendente perfurado como causa.
Long-term antibody response after Covid-19 vaccination in health care workers- a single centre study from Pakistan
Authors: Kanani Fatima , Ejaz Javeria , Anis Sabiha , Mushtaq Mamoona 
Published: February 2025

The retrospective cohort study was planned to determine long-term anti-spike immunoglobulin G levels after receiving coronavirus disease-2019 vaccination by healthcare workers. The study took place between June and July 2022 at the Indus hospital in Karachi. Healthcare workers who had previously screened negative to pre-vaccination Severe Acute Respiratory Syndrome Coronavirus 2 nucleocapsid antibodies were tested for post-vaccination Severe Acute Respiratory Syndrome Coronavirus 2 anti-spike immunoglobulin G levels using a quantitative assay. The test was also performed on the stored pre-vaccination samples of the subjects collected up to 18 months previously. Antibody levels in subjects without infection, with infection and with booster administration were compared. The median post-vaccination anti-spike immunoglobulin G in infected only, infected with routine vaccination and infected with booster values were 1,725.6 IU/mL (interquartile range: 684.80-4,708.9 IU/mL), 2,067.15 IU/mL (interquartile range: 705.33-4,670.4 IU/mL) and 6,139.15 IU/mL (interquartile range: 2,426.05-10,623.40 IU/mL). There was a doubling of antibody titers, from 1,744 IU/mL to 3,829 IU/mL, in those who received a booster versus routine vaccination (p>0.05). The antibodies remained positive more than a year following vaccination.
Key Words: Healthcare workers, Anti-spike IgG, Sinopharm, CanSino-Biologics, Pfizer, Booster.