bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and validation of novel predictive models to predict bone metastasis in newly diagnosed prostate adenocarcinoma based on single-photon emission computed tomography radiomics.
Authors: wang ning , qu shihui , kong weiwei , hua qian , hong zhihui , liu zengli , shi yizhen 
Published: January 2024

Abstract
Purpose
In order to establish and validate novel predictive models for predicting bone metastasis (BM) in newly diagnosed prostate adenocarcinoma (PCa) in single-photon emission computed tomography radiomics.
Method
In a retrospective review of clinical SPECT database, 176 patients (training set: n = 140; validation set: n = 36) who underwent SPECT/CT imaging and histologically confirmed with newly diagnosed PCa from June 2016 to June 2022 were enrolled. Radiomic features were extracted from ROI in a targeted lesion of each patient. Clinical features, including age, t-PSA, and Gleason grades, were included. Statistical tests were then used to eliminate irrelevant and redundant features. Finally, three types of optimized models were constructed for the prediction. Furthermore, 5-fold cross-validation was applied to obtain the sensitivity, specificity, accuracy, and area under the curve (AUC) for performance evaluation. The clinical usefulness of the multivariate models was estimated through decision curve analysis (DCA).
Results
Radiomics signature consisting of 27 selected features was significantly correlated with bone status(P < 0.01 for both training and validation sets). Collectively, the models showed good predictive efficiency. The AUC values ranged from 0.87 to 0.98 in four models. The AUC value of the human experts was 0.655 and 0.872 in the training and validation groups, respectively. Most radiomic models showed better diagnostic accuracy than human experts in the training group and the validation group. DCA also demonstrated the superiority of the radiomics models compared to human experts.
Conclusion
Our proposed models, which incorporate SPECT-based radiomics signature and clinical risk factors, could be a promising auxiliary means to assist radiologists or medical physicians in their subsequent workup to confirm the diagnosis of BM.
Dissecting the manipulation of lufenuron on chitin metabolism, and the sublethal effects on Helicoverpa armigera development
Authors: Ma Long , Zhao Ziwei , Yang Ruihong , Su Xiaofeng , Peng Yingchuan , Zhang Wanna 
Published: January 2024

Abstract
Lufenuron, acting as a chitin synthesis inhibitor of benzoylureas class, is effective against many insect pests, particularly detrimental to their immature stages. However, the insecticidal activity of lufenuron has not been completely elucidated, nor do its disturbing effect on chitin metabolism genes. In this study, our bioassay demonstrated an outstanding toxicity of lufenuron against Helicoverpa armigera larvae. The treated larvae died from abortive molting and metamorphosis defects, and severe separation of epidermis and subcutaneous tissues was observed. Treatment of 3rd- and 4th-instar larvae with LC25 lufenuron significantly extended the duration of larval and pupal stage, reduced the rates of pupation and emergence, and adversely affected pupal weight. Besides, lufenuron can severely reduce chitin content in larval integument in a concentration-dependent manner, and the lufenuron-treated larvae showed reduced trehalose content in their hemolymph. Further analysis using RNA sequencing revealed that 7 of 10 chitin synthesis genes were down-regulated, whereas the expressions of two chitin degradation genes were significantly enhanced. Knockdown of chitin synthase 1 (HaCHS1), uridine diphosphate-N-acetylglucosamine-pyrophosphorylase (HaUAP), phosphoacetyl glucosamine mutase (HaPGM), and glucosamine 6-phosphate N-acetyl-transferase (HaGNPAT) in H. armigera led to significant increases in larval susceptibilities to LC25 lufenuron by 75.48%, 65.0%, 68.42% and 28.0%, respectively. Our findings therefore revealed the adverse effects of sublethal doses of lufenuron on the development of H. armigera larvae, elucidated the perturbations on chitin metabolism, and highlighted the combined administration of insect growth regulators (IRGs) and the RNAi of specific genes would be developed as a promising strategy to efficiently manage insect pests.
Clinical validation of miRNA biomarkers to predict risk of primary non-function of fatty allografts following liver transplantation
Authors: Schönberg Juliette , Borlak Jürgen 
Published: January 2024

Abstract
Background & Aims:
Primary non-function (PNF) of the liver defines an irreversible graft failure without reasonable surgical or immunological causes. PNFs are unpredictable and constitute a life-threating condition that requires high-urgency re-transplantation. As part of a retrospective cohort study, we found PNF to be frequently associated with fatty allografts, and was associated with high mortality after re-transplantation. Based on findings from a fatty allograft PNF animal disease model, we assessed the clinical relevance of miRNA biomarker candidates for their usefulness to predict PNF in human orthotopic liver transplantation (OLT). Furthermore, we investigated their regulation following ischemia-reperfusion injury.
Methods
We recently performed genome wide scans to identify highly regulated miRNAs in a fatty allograft PNF animal disease model and selected 15 miRNAs for their marked tissue regulation (Kulik et al., 2024). We performed histopathology and assayed PNF-associated miRNAs by RT-qPCR in RNA extracts of FFPE tissue blocks of well documented clinical cases. Additionally, we investigated their regulation in pre- and intraoperative liver biopsies and blood samples from patients undergoing elective hepatobiliary surgery to define their function in reperfusion injury.
Results
We established clinical significance for 9 repressed and 2 induced miRNAs in PNF tissue extracts and show the grade of hepatic steatosis to significantly influence expression of miRNA-27b-3p, miRNA-122-3p, miRNA-125a-5p, miRNA-125b-5p and miRNA-192-5p. Following reperfusion injury, we discovered let-7b-5p, miRNA-122-5p, miRNA-125b-5p and miRNA-194-5p as significantly upregulated when pre- and intraoperative liver biopsies were compared. Strikingly, PNF-associated miRNAs are oppositely regulated in plasma samples of successful OLTs and liver resection cases post-surgery. Therefore, we demonstrate selectivity of the miRNA biomarker candidates. Moreover, and based on 21 independent studies, we confirmed the regulation of 8 bloodborne PNF-associated miRNAs in human acute liver failure cases. We therefore establish clinical relevance and predictive power across independent studies.
Conclusions
We identified miRNAs highly predictive of PNF and show their opposite regulation in liver biopsies and blood samples of successfully performed OLTs. Our findings will improve early identification of allografts at risk for PNF, its management and therefore warrant independent validation in clinical trials.
Electrode configurations for transcutaneous stimulation of forearm muscles
Authors: RaviChandran Narrendar , Aw Kean , McDaid Andrew 
Published: January 2024

Abstract
Electrode arrays facilitate customized stimulation delivery by modulating the shape and size of the stimulation area. Still, it is challenging to achieve an ideal response as several factors influence the overall stimulation. Thus, characterizing these factors to optimize stimulation performance is of interest to FES applications. This study evaluates the influence of electrode configurations on transcutaneous stimulation of forearm muscles. For a desired muscle response, different configurations were studied by changing the location of active and return electrodes, and the distance between them. The resulting muscle response was quantified as minimum evocable contraction (MEC). Firstly, the availability of more than one unique electrode configuration to achieve a target response was demonstrated. Secondly, an optimal interelectrode distance for forearm muscles was ~ 80 mm (range of 34.4 to 126.4 mm), which evoked 60–100% MEC. These inferences can help with improving electrode array-based stimulation. The availability of more than one electrode configuration implies the possibility of switching electrodes to emulate asynchronous stimulation that mitigates the onset of fatigue. Also, identifying the optimal distance between the electrodes simplifies electrode calibration and placement routines.
Examining Social Media Usage Patterns among Health Care Providers in Gondar Town: A Cross-Sectional Survey
Authors: Atsbeha Berhanemeskel Weldegerima , Wodaje Mulugeta Negash 
Published: January 2024

Abstract
Background and Purpose: Social media has emerged as a powerful communication and marketing tool that revolutionizes various industries, including healthcare. This study aimed to investigate social media usage patterns and their implications for healthcare providers in Gondar Town.
Methods: A sample of 238 healthcare professionals from diverse backgrounds were surveyed, providing valuable insights into patient demographics, social media adoption, and preferred platforms for personal connections and professional networking.
Results: The results revealed that a majority of participants actively engaged with social media platforms, with Facebook (89.5%) leading as the most popular, followed by Telegram (86.9%) and YouTube (39.7%). The study also sheds light on the preferred duration ofsocial media usage, primarily during evening hours, indicating potential leisure time usage after work. Participants reported using social media for both personal and business purposes, with a significant proportion utilizing it as a marketing tool (68.9%). Social media platforms served as a means to connect with friends and family (95.0%) while also recognizing their potential for increasing brand awareness (27.3%) and boosting leads and sales (34.9%).
Conclusion and recommendation: The correlation analysis revealed interesting relationships between social media usage and factors such as the amount of time spent on social media and intentions to use such media. While the time spent on social media was positively correlated with personal connections, its impact on business-related activities was weaker, emphasizing the need for targeted social media marketing strategies. Practical implications for healthcare providers include adopting diverse social media strategies, leveraging preferred platforms, and balancing personal and business content to effectively engage with their audience. Understanding peak usage hours allows healthcare facilities to optimize their posts and interactions for increased reach and interaction. This study's findings have theoretical implications for validating the diffusion of innovations theory and relationship marketing theories in the healthcare context. Additionally, recognizing social media's significance for professional networking aligns with social network theory, where healthcare professionals can establish connections and share knowledge with peers and industry experts. In conclusion, this study highlights the importance of social media for healthcare providers in Gondar Town and offers valuable insights into their preferences and practices. By strategically harnessing social media's potential, healthcare providers can strengthen patient relationships, enhance brand visibility, and effectively communicate healthcare information within the community.
The Polish-Belarusian border: between mercy and the reason of state
Authors: Supiński Marcin 
Published: January 2024

Celem niniejszego artykułu jest przedstawienie czytelnikowi czym charakteryzują się postawy kolejno miłosierdzia i racji stanu w kontekście wydarzeń mających miejsce na pograniczu polsko-białoruskim, jaki szerzej określany jest kryzysem humanitarnym. Przedstawione zostaną motywacje jakie stoją za przytoczonymi postawami. W artykule zostanie zweryfikowana hipoteza stanowiąca, iż postawa miłosierdzia nie zawsze jest możliwa do realizacji, kiedy to zagrożone jest państwo i jego obywatele, ponieważ władza stojąca na czele tych obywateli ma za zadanie ich ochronę, a dopiero później udzielanie ewentualnej pomocy innym. Obie postawy są zestawione ze sobą. Metodą badawczą jaką zastosowano w pisaniu owego artykułu była metoda empiryczna. Artykuł został podzielony na poszczególne rozdziały. W artykule zostały przedstawione wyniki badań, w ramach których ustalono, że miłosierdzie jest możliwe tylko przez pojedynczych ludzi, a racja stanu jest to postawa jaką kierują się rządzący, w ramach której dążą do bezpieczeństwa obywateli i państwa. Władze państwowe mogą jedynie wspierać działania poszczególnych ludzi czynionych w myśli miłosierdzia. Jednak należy podkreślić, że obecnie zauważalne są dwie postawy miłosierdzia – faktycznego i fasadowego.
ON GENERALIZATIONS OF STIRLING NUMBERS AND SOME WELL-KNOWN MATRICES
Authors: Stanimirović Stefan , Micić Ivana 
Published: January 2024

We introduce a generalization of the Stirling numbers of the first kind and the second kind. By arranging these numbers into matrices, we generalize the Stirling matrices of the first kind and the second kind investigated by Cheon and Kim [Stirling matrix via Pascal matrix, Linear Algebra Appl. 329 (2001) 49–59]. Furthermore, we introduce generalizations of the Pascal matrix and the symmetric Pascal matrix with two real arguments, and generalize earlier results related to the Pascal matrices, Stirling matrices and matrices involving Bell numbers.
Pembuatan Nugget Berbahan Dasar Ikan Tongkol
Authors: Gorintha Moses , Pratiwi Komang Trisna Arcana 
Published: January 2024

Kebutuhan akan makanan yang praktis serta tahan lama akhir akhir ini semakin meningkat terutama di daerah perkotaan, dimana salah satu produk yang semakin digemari saat ini adalah nugget. Dalam penelitian ini peneliti membahas mengenai “Pembuatan Nugget Berbahan Dasar Ikan Tongkol”. Tujuan dalam penelitian ini adalah untuk mengetahui bagaimana kualitas rasa, aroma, tekstur, warna, daya tahan dan biya aproduksi dari nugget berbahan dasar ikan tongkol. Penelitian ini menggunakan 30 orang responden untuk uji organoleptik, sementara pengamatan uji daya tahan dan penghitungan biaya produksi dilakukan oleh penulis sendiri. Data yang telah didapat akan diolah kemudian dibuat pembahasan dengan menggunakan teknik analisis deskriptif. Berdasarkan hasil penelitian, ditemukan bahwa total skor dari uji organoleptik pada produk adalah 500 dimana pada kategori rasa nugget ini mendapat total skor 130 sehingga termasuk ke dalam kategori sangat enak, sementara pada kategori warna nugget ini mendapatkan skor 124 sehingga termasuk ke dalam kategori menarik, sementara pada kategori tektur dan aroma masing masing mendapatkan total skor 125 dan 121 dimana untuk kategori tekstur termasuk ke dalam kategori empuk dan kategori aroma termasuk ke dalam kategori harum. Berdasarkan uji daya tahan produk yang dilakukan dikethaui bahwa produk dapat dikonsumsi sebelum hari ke-7, sementara hasil penghitungan biaya produksi per unit didapatkan bahwa biaya untuk memproduksi produk adalah Rp. 3.200/pcs

The need for practical and durable food has recently been increasing, especially in urban areas, where one of the products that are increasingly popular today is nuggets. In this study, the researchers discussed "Making Nugget Based on Tuna Fish". The purpose of this study was to determine the quality of taste, aroma, texture, color, durability, and production costs of nuggets made from tuna. This study used 30 respondents for organoleptic tests, while observations of endurance tests and calculation of production costs were carried out by the authors themselves. The data that has been obtained will be processed and then made a discussion using descriptive analysis techniques. Based on the results of the study, it was found that the total score from the organoleptic test on the product was 500 whereas the taste category of this nugget got a total score of 130 so it was included in the very good category, while in the color category this nugget got a score of 124 so it was included in the interesting category, while in the texture and aroma categories, each got a total score of 125 and 121 where the texture category was included in the soft category and the aroma category was included in the fragrant category. Based on the product durability test, it is known that the product can be consumed before the 7th day, while the result of calculating the production cost per unit is found that the cost to produce the product is Rp. 3.200/pcs
Kualitas Wingko dengan Bahan Tepung Mocaf
Authors: Satmika Gede , Pambudi Bondan 
Published: January 2024

Wingko adalah makanan yang terbuat dari kelpa, tepung beras ketan, gula, garam, dan air yang memiliki citas rasa manis dan gurih. Tujuan penilitian ini untuk mengetahui kualitas wingko berbahan tepung mocaf. Tepung mocaf adalah tepung yang terbuat dari singkong utuh yang difermentasi. Penulis membuat wingko dengan 4 spesimen yaitu P0 ( 100% tepung beras ketan ) sebagai kontrol, P1 (75% tepung beras ketan & 25 % tepung mocaf ), P2 (50% tepung beras ketan & 50 % tepung mocaf ), dan (100 % tepung mocaf ) mebuat Lalu akan di uji organoleptik dari segi rasa, warna, aroma dan tekstur metode yang digunakan untuk mengumpulkan data ini dengan kuesioner yang akan diuji oleh 20 panelis teridiri dari ahli dari bidang tata boga, mahasiswa, dan masyarakat. Dari hasil penilitian wingko P1 (75% tepung beras ketan dan 25% tepung mocaf ) mendapatkan hasil nilai tertinggi dalam indikator rasa dan aroma. Sedangakn wingko P3 (100% tepung mocaf) mendapatkan nilai tertinggi dalam indikator warna dan tekstur. Selanjutnya akan diuji daya tahan, dari uji daya tahan wingko dapat bertahan selama 2 hari di suhu ruanagn dan dapat bertahan 7 hari bila disimpan pada lemari pendingin dengan suhu 2 derajat celcius. Terakhir akan menghitung biaya produksi.Lokasi yang dijadikan tempat penelitian berlokasi di Jl keboiwa selatan Gg mangga kav 5. Untuk lebih lanjutnya, perlu dilakukan penelitian lebih lanjut untuk mengetahui gizi dari wingko berbahan tepung mocaf.

Wingko is a food made from coconut, glutinous rice flour, sugar, salt, and water that has a sweet and savory taste. The purpose of this study was to determine the quality of wingko made from mocaf flour. Mocaf flour is flour made from fermented whole cassava. The author made wingko with 4 specimens, that is P0 (100% glutinous rice flour) as control, P1 (75% glutinous rice flour & 25% mocaf flour), P2 (50% glutinous rice flour & 50% mocaf flour), and (100% mocaf flour) then will be tested organoleptically in terms of taste, color, aroma and texture the method used to collect this data with a questionnaire that will be tested by 20 panelists consisting of experts from culinary , students, and the society. From the results of the research, Wingko P1 (75% glutinous rice flour and 25% mocaf flour) obtained the highest value in taste and aroma indicators. Meanwhile, Wingko P3 (100% mocaf flour) got the highest score in color and texture indicators. Furthermore, it will be tested for durability, from the durability test, wingko can endure for 2 days at room temperature and can endure 7 days when stored in a refrigerator with a temperature in 2 degrees Celsius. Finally, we will calculate the cost of production. The research location is located on Jl Keboiwa Selatan Gg Mango Kav 5. For further research, it is necessary to conduct further research to determine the nutrition of wingko made from mocaf flour.
Trīs latviešu literatūras klasiķi monogrāfijās
Authors: Priedīte Aija 
Published: January 2024

Izdevniecības Dienas grāmata izdoto monogrāfiju apskats. Jāņa Zālīša monogrāfija par Jāni Ziemeļnieku Kam puķe zied... (2021), Ievas Strukas pētījums par Anšlavu Eglīti Par skaisto un aplamo dzīvi (2022), Arņa Koroševska grāmata par Andreju Upīti Lielais noliedzējs (2022).
Estrategias de enseñanza que den a conocer la geografía tradicional de Venezuela por medio de un software educativo
Authors: Juarez Ana Yelena 
Published: January 2024

La investigación descrita se centra en la creación estrategias de enseñanza en la geografía tradicional de Venezuela, utilizando un software educativo el cual es evaluando por los procesos generadores en la enseñanza. Esta investigación es factible y explicativa, basado en métodos cualitativos que incluyen investigación documental y descriptiva para evaluar los contenidos y atributos relacionados con el software educativo. La población objetivo de esta investigación está compuesta por cuatro (4) docentes especialistas en el área de ciencias sociales, del liceo Nocturno “8 de septiembre”, quienes validan el contenido, se realizó una entrevista con preguntas abiertas. Además, se llevará a cabo una búsqueda exhaustiva de libros y contenido fotográfico para la elaboración del software. El objetivo principal de esta investigación es crear un proceso educativo innovador que fomente la creatividad en la enseñanza de la geografía tradicional de Venezuela. Además, se busca evaluar los procesos generadores de la enseñanza, la inclusión del software educativo se considera una herramienta valiosa para mejorar la calidad del aprendizaje, ya que la creatividad y la innovación son aspectos importantes en la educación y pueden ayudar a fomentar la enseñanza, será parte del contenido del área Memoria, Territorio y Ciudadanía, que busca valores que promuevan la identidad nacional, reconozcan la diversidad cultural, valorar las expresiones y creatividades propias de pueblo Venezolano que lleven al pensamiento crítico y reflexivo del aprendizaje integral y contextualizado.
A bionic hand versus a replanted hand
Authors: Wijk Ulrika , Björkman Anders , Carlsson Ingela K. , Kristiansdottir Freyja , Mrkonjic Ante , Rosén Birgitta , Antfolk Christian 
Published: January 2024

Objective: Evaluation of the hand function affected when replacing a malfunctioning hand by a bionic hand.
Design: Case report.
Subjects: One individual that wished for a better quality of life after unsatisfying hand function following a replantation.
Methods: A quantitative and qualitative evaluation of body functions as well as activity performance and participation before and after a planned amputation and prosthetic fitting is presented.
Results: Improvements were seen in the patient-reported outcome measures (PROMs) that were used regarding activity (Disability of the Arm, Shoulder and Hand [DASH] and Canadian Occupational Performance Measure [COPM]), pain (Neuropathic Pain Symptom Inventory [NPSI], Brief Pain Inventory [BPI], Visual Analogue Scale [VAS]), cold intolerance (CISS) and health related quality of life (SF-36), as well as in the standardised grip function test, Southampton Hand Assessment Procedure (SHAP). No referred sensations were seen but the discriminative touch on the forearm was improved. In the qualitative interview, a relief of pain, a lack of cold intolerance, improved appearance, better grip function and overall emotional wellbeing were expressed.
Conclusions: The planned amputation and subsequent fitting and usage of a hand prosthesis were satisfying for the individual with positive effects on activity and participation.
Clinical relevance: When the hand function after a hand replantation does not reach satisfactory levels, a planned amputation and a prosthetic hand can be the right solution.