bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the economic burden of influenza on the older population in Malaysia
Authors: Mad Tahir Nur Syazana , Ismail Aniza , Aljunid Syed Mohamed , Abdul Aziz Aznida Firzah , Azzeri Amirah , Alkhodary Ahmed Abdelmajed 
Published: November 2023

Background
Influenza is a contagious respiratory illness that can cause life-threatening complications among high-risk groups. Estimating the economic burden of influenza is essential to guide policy‐making on influenza vaccination programmes, especially in resource‐limited settings. This study aimed to estimate the economic burden of influenza on older adults (those aged ≥60 years) in Malaysia from the provider’s perspective.

Methods
The main data source in this study was the MY-DRG Casemix database of a teaching hospital in Malaysia. Cases with principal and secondary diagnoses coded in the International Classification of Diseases version 10 (ICD-10) as J09, J10.0, J10.1, J10.8, J11.0, J11.1, J11.8, J12.8, and J12.9, which represent influenza and its complications, were included in the study. The direct cost of influenza at all severity levels was calculated from the casemix data and guided by a clinical pathway developed by experts. The effect of the variations in costs and incidence rate of influenza for both the casemix and clinical pathway costing approaches was assessed with sensitivity analysis.

Results
A total of 1,599 inpatient and 407 outpatient influenza cases were identified from the MY-DRG Casemix database. Most hospitalised cases were aged <18 years (90.6%), while 77 cases (4.8%) involved older people. Mild, moderate, and severe cases comprised 56.5%, 35.1%, and 8.4% of cases, respectively. The estimated average annual direct costs for managing mild, moderate, and severe influenza were RM2,435 (USD579), RM6,504 (USD1,549), and RM13,282 (USD3,163), respectively. The estimated total annual economic burden of influenza on older adults in Malaysia was RM3.28 billion (USD782 million), which was equivalent to 10.7% of the Ministry of Health Malaysia budget for 2020. The sensitivity analysis indicated that the influenza incidence rate and cost of managing severe influenza were the most important factors influencing the total economic burden.

Conclusions
Overall, our results demonstrated that influenza imposes a substantial economic burden on the older Malaysian population. The high cost of influenza suggested that further efforts are required to implement a preventive programme, such as immunisation for older people, to reduce the disease and economic burdens.
Increased cesarean section rate and premature birth according to modified WHO maternal cardiovascular risk in pregnant women with congenital heart disease
Authors: Wedlund Frida , von Wowern Emma , Hlebowicz Joanna 
Published: November 2023

Background
During pregnancy and delivery, hemodynamics are altered and complex congenital heart disease has been associated with adverse maternal and neonatal outcomes. We sought to investigate pregnancy outcome and complications in relation to complexity of heart condition.

Materials and methods
We studied women with ACHD discussed at multidisciplinary conferences at Lund University Hospital March 2009-May 2021. We studied 149 pregnancies in 101 women. We scored each woman retrospectively according to the modified World Health Organization (mWHO) risk classification and included patients in risk class I (n = 36, 24.1%), II (n = 43, 28.9%), II-III (n = 43, 28.9%), III (n = 24, 16.1%) and IV (n = 3, 2.0%).

Results
Women with mWHO class ≥III underwent cesarean section more often than women in less complex mWHO classes, (OR, 5.1; 95% CI, 2.0–12.5; p<0.001). The odds of premature delivery were significantly higher among pregnant women with mWHO class ≥III (OR, 6.7; 95% CI, 2.6–17.4; p<0.001). We found no difference in incidence of preeclampsia, gestational hypertension, gestational diabetes, hemorrhage >1000 ml or cardiac defect in the neonate depending on WHO-class. Women in mWHO classes III-IV had a higher rate of fetal growth restriction (FGR) compared to women in mWHO classes I, II, II-III (p<0.007).

Conclusions
Our findings indicate that women with more complex heart disease (mWHO classes III or IV) tend to have a higher rate of cesarean section, premature birth and FGR.
Predictive value of serum creatinine and total bilirubin for long-term death in patients with ischemic heart disease: A cohort study
Authors: Seyiti Zulihuma , Yang Long , Kasimujiang Abudushalamu , Dejite Tuohutasheng , Shan Xue-Feng , Gao Xiao-Ming 
Published: November 2023

Background
Ischemic heart disease (IHD) has a high mortality in the population. Although serum creatinine (Cr) and serum total bilirubin (TBil) are rapid and readily available biomarkers in routine blood tests, there is a lack of literature on the prognostic value of combined Cr and TBil tests for IHD. This study aimed to evaluate a combined equation based on Cr and TBil to predict the long-term risk of death in IHD and to find indicators sensitive to the prognosis of IHD patients.

Method
In this study, 2625 patients with IHD were included, and the combined value and combined equations of Cr and TBil were obtained by logistic regression analysis based on Cr and TBil collected at the time of admission. Patients were divided into four groups according to the quartiles of the combined value. COX proportional hazard regression model was used to analyze the risk factors for long-term death in IHD patients. Receiver operating characteristic (ROC) curves were used to evaluate the prognostic effect of Cr, TBil and combined value on long-term death events.

Results
Logistic regression analysis was performed for long-term death events with Cr and TBil as independent variables, and the logit regression model was Logit(P) = 0.0129×TBil+0.007×Cr-0.417. Multifactorial Cox regression analysis showed that high values of the equation were independent risk factors for long-term death events (all-cause death: HR 1.457, 95% CI 1.256–1.689, P<0.001; cardiovascular death: HR 1.452, 95% CI 1.244–1.695, P<0.001). Combined Cr and TBil value are more valuable in predicting long-term death (AUC: 0.609, 95% CI 0.587–0.630, P<0.001).

Conclusion
Combined Cr and TBil assay is superior to single biomarkers for predicting long-term death in patients with IHD. High values of the equation are independent predictors of long-term death and can be used to identify patients at high risk for IHD.
Cost savings in male circumcision post-operative care using two-way text-based follow-up in rural and urban South Africa
Authors: Su Yanfang , Mukora Rachel , Ndebele Felex , Pienaar Jacqueline , Khumalo Calsile , Xu Xinpeng , Tweya Hannock , Sardini Maria , Day Sarah , Sherr Kenneth , Setswe Geoffrey , Feldacker Caryl 
Published: November 2023

Introduction
Voluntary medical male circumcision (VMMC) clients are required to attend multiple post-operative follow-up visits in South Africa. However, with demonstrated VMMC safety, stretched clinic staff in SA may conduct more than 400,000 unnecessary reviews for males without complications, annually. Embedded into a randomized controlled trial (RCT) to test safety of two-way, text-based (2wT) follow-up as compared to routine in-person visits among adult clients, the objective of this study was to compare 2wT and routine post-VMMC care costs in rural and urban South African settings.

Methods
Activity-based costing (ABC) estimated the costs of post-VMMC care, including counselling, follow-ups, and tracing in $US dollars. Transportation for VMMC and follow-up was provided for rural clients in outreach settings but not for urban clients in static sites. Data were collected from National Department of Health VMMC forms, RCT databases, and time-and-motion surveys. Sensitivity analysis presents different follow-up scenarios. We hypothesized that 2wT would save per-client costs overall, with higher savings in rural settings.

Results
VMMC program costs were estimated from 1,084 RCT clients: 537 in routine care and 547 in 2wT. On average, 2wT saved $3.56 per client as compared to routine care. By location, 2wT saved $7.73 per rural client and increased urban costs by $0.59 per client. 2wT would save $2.16 and $7.02 in follow-up program costs if men attended one or two post-VMMC visits, respectively.

Conclusion
Quality 2wT follow-up care reduces overall post-VMMC care costs by supporting most men to heal at home while triaging clients with potential complications to timely, in-person care. 2wT saves more in rural areas where 2wT offsets transportation costs. Minimal additional 2wT costs in urban areas reflect high care quality and client engagement, a worthy investment for improved VMMC service delivery. 2wT scale-up in South Africa could significantly reduce overall VMMC costs while maintaining service quality.
Space and Time in African Cinema and Cine-scapes, Kenneth W. Harrow (2022)
Authors: Mututa Addamms 
Published: November 2023

Review of: Space and Time in African Cinema and Cine-scapes, Kenneth W. Harrow (2022)
New York and London: Routledge, 238 pp.,
ISBN 978-1-00328-889-3, e-book, $35.09
Comprehensive Assessment of Nutrition and Dietary Influences in Hypermobile Ehlers-Danlos Syndrome—A Cross-sectional Study
Authors: Topan Rabia , Pandya Shraya , Williams Sarah , Ruffle James K. , Zarate-Lopez Natalia , Aziz Qasim , Fikree Asma 
Published: November 2023

INTRODUCTION:
Disorders of gut-brain interaction (DGBI) are common in patients with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorder (hEDS/HSD). Food is a known trigger for DGBI symptoms, which often leads to dietary alterations and, increasingly, nutrition support. We aimed to explore dietary behaviors and influencing factors in patients with hEDS/HSD.

METHODS:
In a cross-sectional study, patients with hEDS/HSD were recruited from Ehlers-Danlos Support UK (nontertiary) and tertiary neurogastroenterology clinics to complete questionnaires characterizing the following: dietary behaviors, nutrition support, DGBI (Rome IV), gastrointestinal symptoms, anxiety, depression, avoidant restrictive food intake disorder (ARFID), mast cell activation syndrome, postural tachycardia syndrome (PoTS), and quality of life. We used stepwise logistic regression to ascertain which factors were associated with dietary behaviors and nutrition support.

RESULTS:
Of 680 participants (95% female, median age 39 years), 62.1% altered their diet in the last year and 62.3% regularly skipped meals. Altered diet was associated with the following: reflux symptoms (P < 0.001), functional dyspepsia (P = 0.008), reported mast cell activation syndrome (P < 0.001), and a positive screen for ARFID, specifically fear of eating and low interest (P < 0.001). Approximately 31.7% of those who altered their diet required nutrition support. The strongest predictor of requiring nutrition support was a positive screen for ARFID, specifically fear of eating (OR: 4.97, 95% CI: 2.09–11.8, P < 0.001).

DISCUSSION:
Altered diet is very common in the patients with hEDS/HSD we studied and influenced by functional dyspepsia, reflux symptoms, and ARFID. Those with ARFID have a 4-fold increased risk of requiring nutrition support, and therefore, it is paramount that psychological support is offered in parallel with dietary support in the management of DGBI in hEDS/HSD.
Quaternary Geology of the Washington-Jasper Area
Authors: Antinao Jose Luis , Davis Ginger , Loope Henry 
Published: November 2023

"Quaternary Geology of the Washington-Jasper Area" was created to present basic quaternary geologic information that contributes to the characterization of potential aggregate resources, characterization of bedrock aquifer systems, and analysis of the overlying predominantly glacial deposits. This map is based on data compiled from project field observations and project exploratory borings, complemented with IGWS cartographic (e.g., Gray, 1989) and archive borehole data, select Indiana Department of Natural Resources water well logs, and United States Department of Agriculture soil survey maps. Expert knowledge of fluvial, glacifluvial and ice-marginal environments was used to draw contacts between units.

This geologic map was funded in part through the STATEMAP program supported by the U.S. Geological Survey under Cooperative Agreement No. G21AC10646.

"Quaternary Geology of the Washington-Jasper Area" is a composite geodata set that conforms to "GeMS (Geologic Map Schema)--a standard format for the digital publication of geologic maps," available at http://ngmdb.usgs.gov/Info/standards/GeMS/. Metadata records associated with each element within the geodata set contain more detailed descriptions of their purposes, constituent entities, and attributes. An OPEN shapefile version of the data set is also available. It consists of shapefiles, DBF files, and delimited text files and retains all information in the native geodatabase, but some programming will likely be necessary to assemble these components into usable formats.
La problemática y el tratamiento de la competencia sociolingüística y la competencia pragmática en la clase de ELE desde un enfoque novedoso
Authors: Spychała-Wawrzyniak Małgorzata , Barros Díez Esther 
Published: November 2023

The purpose of our article is to analyze the main differences between sociolinguistic competence and pragmatic competence, integrated within communicative competence. Firstly, we will try to define, characterize, and exemplify the tools inherent to sociolinguistic competence in comparison with pragmatic competence. We will present that courtesy formulas in language teaching should be included within the pragmatic competence and not sociolinguistic as it has been done usually. To do this, we will use the multilingual competence on which the CEFR-CV (2020) places considerable emphasis. Likewise, the concepts of sociolinguistic and pragmatic competences will be explained taking as a starting point the components of communicative competence which, in turn, encompasses intercultural competences. On the other hand, we will also deal with the role and challenges of the intercultural speaker as a mediator of pragmatic, sociolinguistic and sociocultural meanings. In the last part of the article, we will focus on the field of teaching Spanish as a foreign language (hereinafter ELE), specifically, on the development of communicative competence from a sociolinguistic and pragmatic perspective. We will analyze some ELE manuals to reflect on and show the work proposals related to pragmatic and sociolinguistic knowledge (especially at level A1) carried out by their authors.
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration
Authors: Nakazato Ryota , Matsuda Yuki , Ijaz Faryal , Ikegami Koji 
Published: November 2023

AbstractVarious mammalian cells have autonomous cellular clocks that are produced by the transcriptional cycle of clock genes. Cellular clocks provide circadian rhythms for cellular functions via transcriptional and cytoskeletal regulation. The vast majority of mammalian cells possess a primary cilium, an organelle protruding from the cell surface. Here, we investigated the little‐known relationship between circadian rhythm and primary cilia. The length and number of primary cilia showed circadian dynamics both in vitro and in vivo. The circadian rhythm of primary cilium length was abolished by SR9011 and Bmal1 knockout. A centrosomal protein, pericentrin, transiently accumulates in centriolar satellites, the base of primary cilia at the shortest cilia phase, and induces elongation of primary cilia at the longest cilia phase in the circadian rhythm of primary cilia. In addition, rhythmic cell migration during wound healing depends on the length of primary cilia and affects the rate of wound healing. Our findings demonstrate that the circadian dynamics of primary cilium length by clock genes control fibroblast migration and could provide new insights into chronobiology.
Adipolin (C1QTNF12) is a new adipokine in female reproduction: expression and function in porcine granulosa cells
Authors: Barbe Alix , Kurowska Patrycja , Rame Christelle , Froment Pascal , Rak Agnieszka , Dupont Joëlle 
Published: November 2023

In brief
Adipolin (C1QTNF12) has been described as a regulator of metabolism and is linked with the pathophysiology of PCOS. In this study, for the first time, we show the expression of C1QTNF12 in granulosa cells and its positive effect on porcine granulosa cell proliferation and steroid synthesis.

Abstract
Adipolin (C1QTNF12) is a recently discovered adipokine that plays an important role in glucose and insulin level regulation. Previous studies showed its reduced level in serum of women suffering from polycystic ovarian syndrome; however, whether C1QTNF12 regulates ovary function is still unknown. The aim of the study was first to determine the level of C1QTNF12 in the porcine ovarian follicles granulosa cells (Gc) and then its in vitro effect on proliferation and steroidogenesis as well as phosphorylation of several signalling pathways. Our results showed that the expression of C1QTNF12 was dependent on follicle size and was higher at the mRNA and protein level in Gc of small than large follicles from both prepubertal and mature animals. Similar pattern was observed for C1QTNF12 concentration in porcine follicular fluid. Additionally, we observed immunolocalisation of C1QTNF12 in Gc, theca cells and oocytes. We found that C1QTNF12 stimulated porcine Gc proliferation via the activation of protein kinase B (AKT). Moreover, C1QTNF12 enhanced progesterone, testosterone and oestradiol secretion by elevating STAR, CYP11A1, HSD3B and CYP19A1 mRNA expression and by activation of MAP3/1 pathway. Additionally, C1QTNF12 increased pMAP3/1-to-MAP3/1 protein expression ratio and enhanced IGF1-induced pTyr-IGF1Rβ-to-IGFR1β and pMAP3/1-to-MAP3/1 protein ratios. Taken together, C1QTNF12 could act directly on proliferation and steroid synthesis and serve as an important factor in in vivo ovarian follicle function, possibly regulating the course of folliculogenesis.
Nursing Sensitive Outcomes evaluation in the Emergency Department: An Umbrella Review
Authors: Feller Eartha Agatha , Di Mario Sofia , Filomeno Lucia , La Torre Giuseppe 
Published: November 2023

Objective. The aim of this review was to identify reported nursing-sensitive outcomes in the Emergency Department to date.
Methods. An Umbrella review was conducted. Four databases, CINAHL, Pubmed, Web of Science and Scopus, were searched from inception until October 2022. MeSH terms were: "nursing", "sensitivity and specificity", "emergency service, hospital", "nursing care". Two reviewers independently screened studies against the inclusion criteria for eligibility, extracted data and assessed study quality with the SIGN tool. Results of the included studies were summarized and described in themes for narrative analysis. The study was enrolled in the PROSPERO registry (CRD42022376941) and PRISMA guidelines were followed.
Results. The search strategy yielded 2289 records. After duplicate removal, title, abstract and full-text eligibility screening, nine systematic reviews were included in the review. A total of 35 nursing-sensitive outcomes were reported. The most described outcomes were waiting times, patient satisfaction and time to treatment. The less measured were mortality, left without being seen and physical function. Synthesizing nursing-sensitive outcomes in themes for reporting, the most measured outcomes were within the safety domain (n=20), followed by the clinical (n=9), perceptual (n=5) and the least explored functional domain (n=1).
Conclusion. Nursing sensitive outcomes research in emergency nursing practice is a conceptual challenge still in its early stage. Several nursing-sensitive outcomes were identified in this review that can evaluate the contribution of emergency department nursing care to patient outcomes. Further research is required to explore patient outcomes sensitive to emergency nursing care.
Effect of Digital applications on maternal as well as neonatal outcomes in Young pregnant girls: A Scope Review
Authors: Kaur Jasneet , Upendra Sheela , Barde Shital 
Published: November 2023

Objective. To understand the effect of digital applications on maternal and neonatal outcomes in young pregnant girls.
Methods. A PubMed, CINAHL and Medline online database search was conducted, and related studies were included the databases were searched in order to carry out a more in detailed search of the available literature utilizing keywords like “digital technology”; “adolescent mothers”; and “infant, newborn”, as well as Boolean operators to generate papers pertinent which were correlating with the objective of the study.
Results. The findings revealed that the PPPs employed produced both positive and negative effects on mothers and newborns. Some were effective, especially in aspects related to improved mental health, while others did not necessarily support the adolescents in preparing for pregnancy and childbirth, but rather raised their anxiety levels. Similarly, the use of these apps decreased the use of emergency neonatal services by the adolescent mothers and the infants were lower in likelihood of exclusive breastfeeding. Participants appreciated the social media-based instruction, but this exposure did not translate into considerable change in routines and behaviors.
Conclusion. Digital and web-based solutions had the ability to influence adolescent pregnancy outcomes, but further research is needed to assess the extent to which these support services are useful in this Population Group.
The effect of interventional program underpinned by health belief model on awareness, attitude, and performance of nurses in preventing nosocomial infections: A randomized controlled trial study
Authors: Hosseinpour Mahmoud , Eslami Akbar Rasool , Faseleh Jahromi Mohsen , Badiyepeymaiejahromi Zohreh 
Published: November 2023

Objective. The present study examined the effect of an interventional program underpinned by the Health Belief Model (HBM) on nurses’ awareness, attitude, and performance in preventing nosocomial infections.
Methods. This randomized controlled trial study was performed on 60 clinical nurses in lar, Iran. Nurses were selected using the simple random sampling method and assigned to two experimental (n=30) and control (n=30) groups. Data collection tool included the valid and reliable questionnaire was developed by Soleimani et al. The research intervention consisted of five 90-min sessions based on the health belief model in preventing hospital infection for experimental group. Before the intervention, immediately and two months after the intervention, the two groups completed the questionnaire. The control group received no intervention.
Results. Data analysis showed that the differences between the two groups was statistically significant immediately and two months after the intervention (p<0.05). In experimental group the changes in the mean score of knowledge, attitude and performance of nurses before, immediately and two months after the intervention were significant (p<0.05), but in the control group, only the changes in the mean score of performance were significant (p<0.05).
Conclusion. The results showed that the HBM-based intervention is effective in promoting nurses’ knowledge, attitude, and performance in preventing nosocomial infections. hence, periodical and in-service HBM-based training programs on preventing nosocomial infections are recommended to be held for nurses.