bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expediting High‐Yield Mxene Carbides and Nitrides Synthesis for Next‐Generation 2D Materials
Authors: Qureshi Nilam , Choi Chang‐Ho , Doh Jaehyeok 
Published: December 2023

AbstractThis research aims to enhance MXene (Ti3C2Tx) synthesis from MAX phases (Ti3AlC2) through a hydro‐solvothermal exfoliation process, with a focus on reducing time and temperature requirements. Prior hydrothermal studies have encountered challenges due to high reaction temperatures. In comparison to previous research, this work achieves superior results at lower temperatures. Two optimized MXene preparation routes are investigated and the etchant's impact on MXene surface chemistry is analyzed. Comprehensive X‐ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X‐ray Spectroscopy (EDS), X‐ray Photoelectron Spectroscopy (XPS), Fourier transform infrared (FTIR), Raman spectroscopy, and Atomic Force Microscopy (AFM) analyses provide insights into hydrosolvothermal synthesis (H‐Ti3C2Tx ) multilayers(ML), confirming/challenging recent spectroscopic assignments. Remarkably, hydro‐solvothermal treatment induces significant changes in surface composition, increasing hydroxyl (─OH) groups without oxidation and reducing fluorine (─F) groups on the H‐ Ti3C2Tx surface. These study's results hold promise for applications in energy storage and electromagnetic wave shielding. This research accomplishes three main objectives: i) secures hydrothermal synthesis of two‐ dimensional (2D) MXenes, ii) efficiently utilizes lithium fluroide‐ hydrochloric acid (LiF−HCl) etching for high‐quality MXene flakes with minimal defects, and iii) understands hydro‐solvothermal kinetics. This approach advances MXene synthesis with enhanced material quality and production efficiency (>98%), in a more eco‐friendly and safer manner. This eco‐conscious synthesis underscores MXene's versatility and eco‐friendly methods' significance, reshaping MXene exploration and sustainable material synthesis, with potential implications for future electrochemical applications.
Dynamic observer‐based fault estimation and fault‐tolerant control for switched stochastic systems with multiple faults
Authors: Zhang Jiuling , Han Jian , Liu Xiuhua , Wei Xinjiang 
Published: December 2023

AbstractThe fault estimation (FE) and fault‐tolerant control (FTC) problems are studied for the switched system with sensor fault, actuator fault, and stochastic noise. The dynamic FE observers are used to reconstruct the system states and faults at the same time. Differently from the classical observer design method, in the process of observers design, both the output information and its derivative are introduced to improve the estimation performance, especially in the case of the systems subject time‐varying fault. Based on the coordinate transformation, the output derivative is not appeared in the observers, which means that the proposed dynamic observers can be used for the cased that the output derivative is unmeasured. Utilizing the estimate information, the observer‐based FTC scheme is given. For any switching signal, the linear matrix inequality (LMI) conditions are provided, which can ensure that the entire system is mean‐square exponentially stable (MSES). Finally, simulation examples show the effectiveness of the observer and controller.
Sensitivity of urine cytology in detecting high‐grade urothelial carcinoma in patients with neoplastic urinary bladder diverticula: A major cancer center experience
Authors: Alhamar Mohamed , Al‐Ahmadie Hikmat A. , Feratovic Rusmir , Lin Oscar 
Published: December 2023

AbstractBackgroundBladder diverticula are herniations of bladder urothelium and mucosa through the muscularis propria. The reported incidence of neoplasia arising in bladder diverticula is widely variable. The authors’ objective was to study the characteristics and sensitivity of urine cytology in these patients with emphasis on primary intradiverticular bladder cancer (IDBC).MethodsA 17‐year, retrospective review of all resected bladder diverticula associated with bladder carcinoma was performed. Cases that had complete diverticular resections and preresection urine samples were included in this study. The cases were divided into either primary IDBC or primary extradiverticular bladder cancer (EDBC). Demographic data and urine cytology characteristics were recorded, and sensitivity was calculated. For IDBC, a comparison between voided and cystoscopic urines was done for cases that had both collection methods performed.ResultsOf 70 patients with IDBC, 47 patients had urine cytology results that were either positive for high grade‐urothelial carcinoma (HG‐UC) or suspicious for HG‐UC. The sensitivity for HG‐UC in IDBC samples was 80%, compared with 82% in EDBC samples (p > .05). Also, 28 patients in the IDBC group had both voided and cystoscopic urine samples for comparisons; in seven patients, the voided urine sample yielded a more definitive diagnosis; in 10 patients, the cystoscopic urine sample yielded a more definitive diagnosis; and, in 11 patients, both samples were equally diagnostic (p > .05).ConclusionsThe characteristics and sensitivity of urine cytology in bladder diverticula were investigated in association with neoplasia, with an emphasis on primary intradiverticular bladder cancer. The results indicated that urine cytology remains a reliable screening and diagnostic test for detecting IDBC, with sensitivity similar to that for detecting EDBC, and no significant difference was noted between voided and cystoscopic samples.
A Randomized, Single‐Dose, Parallel‐Controlled Phase 1 Clinical Comparison of an Omalizumab Biosimilar Candidate with Reference Omalizumab in Healthy Chinese Male Volunteers
Authors: Cheng Jie , Wang Chenguang , Xu Jin , Zhao Chunyang , Song Rong , Wang Yijun , Zou Yang , Zhang Xunmin , Shan Yong , Zhou Jian , Jia Jing‐Ying 
Published: December 2023

AbstractThis study evaluated the bioequivalence of omalizumab, a humanized monoclonal antibody against immunoglobulin‐E (IgE), with one of its biosimilar candidates. The study was designed as a randomized, double‐blind, parallel‐controlled trial. A total of subjects who met the inclusion criteria and did not meet the exclusion criteria were dynamically randomly assigned to receive the test drug or the reference drug with a single subcutaneous injection of 150 mg by the minimization method. The test group and the reference group had similar demographic characteristics and baseline characteristics of total IgE. The 90% confidence interval of the geometric average ratio of the area under the serum concentration–time curve from the time 0 to the time of last quantifiable concentration, the area under the serum concentration curve from time 0 to infinity, and the maximum observed serum concentration between the 2 groups were within 80%‐125%, showing bioequivalence. The changing trend of total and free IgE in the 2 groups was similar after administration, proving the pharmacodynamic similarity. The 2 groups had no significant difference in the positive rate of antidrug antibodies, and the total positive rate of neutralizing antibodies was 0. The incidence of treatment‐emergent adverse events and treatment‐related adverse events were similar between the 2 groups, with no serious adverse events. This study shows that the test drug had similar pharmacokinetics, immunogenicity, and safety to the reference omalizumab in healthy male subjects.
On developing Block‐Chain based Secure Storage Model (BSSM) with auditing and integrity analysis in the cloud
Authors: Apirajitha Pichai Subramanian , Sathianesan Godfrey Winster 
Published: December 2023

SummaryIn present scenario, Cloud Computing is developing vast, as the resources are utilized by many people and provided on‐demand. Recent works on cloud reports the success rates of cyber activities using cloud models for deceptive actions, because of its significant features and lack of apposite forensic models for cloud. For developing a cloud model for forensic support is an important and intricate issue like, directorial and technical challenges due to system distribution, virtualization, and dynamic characteristic of nodes. Considering the issues, this article develops a Block‐chain based Secure Storage Model (BSSM) incorporating Integrity and Auditing Examination Model for evaluating reliability of forensic data and auditing for validation. Moreover, this model effectively works on the domain of Forensic as a Service (FaaS) in cloud. The forensic data are formed into block‐chain for ensuring security. The model also aids in reducing the storage space effectively and the auditing and integrity analysis model incorporated in this work minimizes the dependency of trusts on Cloud Service Provider (CSP). And, the evaluation results show that the proposed model effectively achieves the objective in better way than compared works.
Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis
Authors: Zheng Anhao , Hu Naiwen , Xu Jing , Yuan Ye , Zhang Shumin , Chen Wenbin , Bai Yanyan , Sun Hongsheng 
Published: December 2023

AbstractObjectiveB‐cell activating factor (BAFF) is a key regulator of primary Sjögren's syndrome (pSS), which is characterized by B‐lymphocyte hyperactivity. BAFF, also known as tumor necrosis factor ligand superfamily member 13B, is encoded by TNFSF13B. This study aimed to explore the possible relationships between five single‐nucleotide polymorphisms (SNPs) of TNFSF13B (rs9514827, rs1041569, rs9514828, rs1224141, and rs12583006) and pSS susceptibility.MethodsWe searched the following databases for articles on TNFSF13B polymorphism and pSS published up to January 2023: PubMed, Cochrane, Elsevier, Web of Science, CNKI, CQVIP, and WanFang. The odds ratios (with 95% confidence intervals) of genotypes and SNP alleles of TNFSF13B were investigated in patients with pSS to determine their relationships with pSS.ResultsThis meta‐analysis employing the fixed‐effect model comprised three studies of pSS patients and randomly selected healthy controls (HCs), revealing statistically significant relationships between pSS susceptibility and two SNPs: rs1041569 and rs12583006. Because rs1041569 was not in Hardy‐Weinberg equilibrium in the HC group, it was eliminated from the analysis.ConclusionsPolymorphisms in the BAFF (TNFSF13B) gene were related to vulnerability to pSS among pSS patients and HCs alike. The SNP rs12583006 was significantly related to pSS susceptibility in pSS patients.
A community‐based dynamic choice model for HIV prevention improves PrEP and PEP coverage in rural Uganda and Kenya: a cluster randomized trial
Authors: Kakande Elijah R. , Ayieko James , Sunday Helen , Biira Edith , Nyabuti Marilyn , Agengo George , Kabami Jane , Aoko Colette , Atuhaire Hellen N. , Sang Norton , Owaranganise Asiphas , Litunya Janice , Mugoma Erick W. , Chamie Gabriel , Peng James , Schrom John , Bacon Melanie C. , Kamya Moses R. , Havlir Diane V. , Petersen Maya L. , Balzer Laura B. ,   for the SEARCH Study Team
Published: December 2023

AbstractIntroductionOptimizing HIV prevention may require structured approaches for providing client‐centred choices as well as community‐based entry points and delivery. We evaluated the effect of a dynamic choice model for HIV prevention, delivered by community health workers (CHWs) with clinician support, on the use of biomedical prevention among persons at risk of HIV in rural East Africa.MethodsWe conducted a cluster randomized trial among persons (≥15 years) with current or anticipated HIV risk in 16 villages in Uganda and Kenya (SEARCH; NCT04810650). The intervention was a client‐centred HIV prevention model, including (1) structured client choice of product (pre‐exposure prophylaxis [PrEP] or post‐exposure prophylaxis [PEP]), service location (clinic or out‐of‐clinic) and HIV testing modality (self‐test or rapid test), with the ability to switch over time; (2) a structured assessment of patient barriers and development of a personalized support plan; and (3) phone access to a clinician 24/7. The intervention was delivered by CHWs and supported by clinicians who oversaw PrEP and PEP initiation and monitoring. Participants in control villages were referred to local health facilities for HIV prevention services, delivered by Ministry of Health staff. The primary outcome was biomedical prevention coverage: a proportion of 48‐week follow‐up with self‐reported PrEP or PEP use.ResultsFrom May to July 2021, we enrolled 429 people (212 intervention; 217 control): 57% women and 35% aged 15–24 years. Among intervention participants, 58% chose PrEP and 58% chose PEP at least once over follow‐up; self‐testing increased from 52% (baseline) to 71% (week 48); ≥98% chose out‐of‐facility service delivery. Among 413 (96%) participants with the primary outcome ascertained, average biomedical prevention coverage was 28.0% in the intervention versus 0.5% in the control: a difference of 27.5% (95% CI: 23.0–31.9%, p<0.001). Impact was larger during periods of self‐reported HIV risk: 36.6% coverage in intervention versus 0.9% in control, a difference of 35.7% (95% CI: 27.5–43.9, p<0.001). Intervention effects were seen across subgroups defined by sex, age group and alcohol use.ConclusionsA client‐centred dynamic choice HIV prevention intervention, including the option to switch between products and CHW‐based delivery in the community, increased biomedical prevention coverage by 27.5%. However, substantial person‐time at risk of HIV remained uncovered.
Nasal spray of an IgM‐like ACE2 fusion protein HH‐120 prevents SARS‐CoV‐2 infection: Two investigator‐initiated postexposure prophylaxis trials
Authors: Song Rui , Chen Xiaoyou , Li Baoliang , Ni Jun , Zhou Yunao , Zhang Hongbin , Liang Xiao , Zou Liangfeng , Liu Juan , Yang Fang , Li Guangyu , Guo Xiaodi , Liu Zhe , Mao Fengfeng , Lei Cong , Sui Jianhua , Li Wenhui , Jin Ronghua 
Published: December 2023

AbstractHH‐120, an IgM‐like angiotensin converting enzyme 2 (ACE2) fusion protein, has been developed as a nasal spray against Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and is currently undergoing human trials. HH‐120 nasal spray was assessed for postexposure prophylaxis (PEP) in two investigator‐initiated (NS01 and NS02) trials with different risk levels of SARS‐CoV‐2 exposure. NS01 enrolled family caregiver participants who had continuous contacts with laboratory‐confirmed index cases; NS02 enrolled participants who had general contacts (Part 1) or close contacts (Part 2) with index cases. The primary endpoints were safety and laboratory‐confirmed and/or symptomatic SARS‐CoV‐2 infection. In NS01 trial (14 participants), the SARS‐CoV‐2 infection rates were 25% in the HH‐120 group and 83.3% in the external control group (relative risk reduction [RRR]: 70.0%). In NS02‐Part 1 (193 participants), the infection rates were 4% (HH‐120) versus 11.3% (placebo), symptomatic infection rates were 0.8% versus 3.5%, hence with a RRR of 64.6% and 77.1%, respectively. In Part 2 (76 participants), the infection rates were 17.1% (HH‐120) versus 30.4% (placebo), symptomatic infection rates were 7.5% versus 27.3%, with a RRR of 43.8% and 72.5%, respectively. No HH‐120‐related serious adverse effects were observed. The HH‐120 nasal spray used as PEP was safe and effective in preventing laboratory‐confirmed and symptomatic SARS‐CoV‐2 infection.
A minireview on vermicompost and vermiwash as green pesticide for sustainable crop production: Approaches, applications, and advancements
Authors: Singh Tanvi , Kapila Rachna , Kumar Maheep 
Published: December 2023

AbstractIndiscriminate use of chemicals is the main cause of reduction in crop yield as well as certain serious diseases. There is an increased demand of organic substitutes which can be met by production of technology that involves the use of organic and environment friendly fertilizers. Vermicompost and vermiwash are suitable substitute for chemical fertilizer. In vermicomposting, organic matter is exposed to bacteria and enzymes of earthworm gut that alter the nutritive constituents and provide the unique consistency and property to vermicompost, also the derived leachate is vermiwash. Chemically, they consist of mucous, proteins, hormones, enzymes, macronutrients, micronutrients, and several microorganisms. Vermicompost and vermiwash hold immense potential for sustainable crop production by the application as fertilizer, biopesticide and disease control, food security, enhancing salinity tolerance as well as in allied fields. This technology is also undergoing advancements with the progression of science and technology. This review focusses on the approaches for preparing vermicompost and vermiwash, applications in the field of sustainable crop production and others as well as advancements in this technology.
Effects of different culture modes on the storage quality of tilapia (Oreochromis mossambicus) fillets at 4°C
Authors: Zhao Dongya , Luo Tao , Liu Yuqiao , Shu Rui , Hong Hui , Luo Yongkang , Tan Yuqing 
Published: December 2023

AbstractBackgroundWith tilapia's increasing production and aquaculture modes' diversity, container culture's effect on fish storage quality remains unclear. Fish storage quality is related to different attributes such as organoleptic, microbiological, and physiochemical qualities. The alterations of the sensory, microbiological, and physiochemical quality of container and pond‐cultured tilapia stored at 4°C were studied to investigate the effect of container culture mode on the quality of tilapia during storage.ResultsDuring storage, the TVC of pond‐cultured tilapia was higher than container‐cultured tilapia at 3–5 days. On 3rd day, the K value was higher in pond‐cultured tilapia, while container‐cultured tilapia had significantly higher IMP content. By 5th day, pond‐cultured tilapia had higher pH, while container‐cultured tilapia had a lower redness–greenness value. On 9th day, HxR content was higher in pond‐cultured tilapia. Shewanella was the main spoilage microbe in pond‐cultured tilapia, while Pseudomonas dominated in container‐cultured tilapia. On 11th day, histamine content was significantly higher in pond‐cultured tilapia.ConclusionsResults indicated that compared with pond‐cultured tilapia, container‐cultured tilapia performs better due to lower pH. The difference in microbial community composition between the two groups may be related to water quality. Overall, container culture is a potential method which is comparable to pond culture.
Effects of bilateral repetitive transcranial magnetic stimulation on prospective memory in patients with schizophrenia: A double‐blind randomized controlled clinical trial
Authors: Xue Fen , Wang Xin‐Fu , Kong Fan‐Ni , Yin Tian‐Lu , Wang Yu‐Hong , Shi Li‐Da , Liu Xiao‐Wen , Yu Hui‐Jing , Liu Li‐Jun , Zhu Ping , Qi Xiao‐Xue , Xu Xue‐Jing , Hu Hong‐Pu , Li Su‐Xia 
Published: December 2023

AbstractAimsTo investigate effects of repetitive transcranial magnetic stimulation (rTMS) on the prospective memory (PM) in patients with schizophrenia (SCZ).MethodsFifty of 71 patients completed this double‐blind placebo‐controlled randomized trial and compared with 18 healthy controls' (HCs) PM outcomes. Bilateral 20 Hz rTMS to the dorsolateral prefrontal cortex at 90% RMT administered 5 weekdays for 4 weeks for a total of 20 treatments. The Positive and Negative Symptom Scale (PANSS), the Scale for the Assessment of Negative Symptoms (SANS), and PM test were assessed before and after treatment.ResultsBoth Event‐based PM (EBPM) and Time‐based PM (TBPM) scores at baseline were significantly lower in patients with SCZ than that in HCs. After rTMS treatments, the scores of EBPM in patients with SCZ was significantly improved and had no differences from that in HCs, while the scores of TBPM did not improved. The negative symptom scores on PANSS and the scores of almost all subscales and total scores of SANS were significantly improved in both groups.ConclusionsOur findings indicated that bilateral high‐frequency rTMS treatment can alleviate EBPM but not TBPM in patients with SCZ, as well as improve the negative symptoms. Significance: Our results provide one therapeutic option for PM in patients with SCZ.
Monogenic conditions and central nervous system anomalies: A prospective study, systematic review and meta‐analysis
Authors: Blayney Gillian V. , Laffan Eoghan , Jacob Preethi A. , Baptiste Caitlin D. , Gabriel Heinz , Sparks Teresa N. , Yaron Yuval , Norton Mary E. , Diderich Karin , Wang Yiming , Chong Karen , Chitayat David , Saini Neelam , Aggarwal Shagun , Pauta Montse , Borrell Antoni , Gilmore Kelly , Chandler Natalie J. , Allen Stephanie , Vora Neeta , Noor Abdul , Monaghan Caitriona , Kilby Mark D. , Wapner Ronald J. , Chitty Lyn S. , Mone Fionnuala 
Published: December 2023

AbstractObjectivesDetermine the incremental diagnostic yield of prenatal exome sequencing (pES) over chromosome microarray (CMA) or G‐banding karyotype in fetuses with central nervous system (CNS) abnormalities.MethodsData were collected via electronic searches from January 2010 to April 2022 in MEDLINE, Cochrane, Web of Science and EMBASE. The NHS England prenatal exome cohort was also included. Incremental yield was calculated as a pooled value using a random‐effects model.ResultsThirty studies were included (n = 1583 cases). The incremental yield with pES for any CNS anomaly was 32% [95%CI 27%–36%; I2 = 72%]. Subgroup analysis revealed apparent incremental yields in; (a) isolated CNS anomalies; 27% [95%CI 19%–34%; I2 = 74%]; (b) single CNS anomaly; 16% [95% CI 10%–23%; I2 = 41%]; (c) more than one CNS anomaly; 31% [95% Cl 21%–40%; I2 = 56%]; and (d) the anatomical subtype with the most optimal yield was Type 1 malformation of cortical development, related to abnormal cell proliferation or apoptosis, incorporating microcephalies, megalencephalies and dysplasia; 40% (22%–57%; I2 = 68%). The commonest syndromes in isolated cases were Lissencephaly 3 and X‐linked hydrocephalus.ConclusionsPrenatal exome sequencing provides a high incremental diagnostic yield in fetuses with CNS abnormalities with optimal yields in cases with multiple CNS anomalies, particularly those affecting the midline, posterior fossa and cortex.
Postnatal outcome of children with antenatal colonic hyperechogenicity
Authors: Fuchs Florent , Rodriguez Alexis , Mousty Eve , Morin Denis , Roubertie Agathe , Wells Constance F. , Prodhomme Olivier , Benoist Jean‐François , Dreux Sophie , Faure Jean‐Michel , Willems Marjolaine 
Published: December 2023

AbstractObjectiveTo evaluate the postnatal outcome of children with antenatal colonic hyperechogenicity, currently considered as a sign of lysinuria‐cystinuria, but which may also be a sign of other disorders with a more severe prognosis.MethodWe carried out a French multi‐centric retrospective study via 15 Multidisciplinary Center for Prenatal Diagnosis from January 2011 to January 2021. We included pregnancies for which fetal colonic hyperechogenicity had been demonstrated. We collected the investigations performed during pregnancy and at birth as well as the main clinical features of the mother and the child. We then established the prevalence of pathologies such as lysinuria‐cystinuria (LC), hypotonia‐cystinuria syndrome (HC), or lysinuric protein intolerance (LPI).ResultsAmong the 33 cases of colonic hyperechogenicity collected, and after exclusion of those lost to follow‐up, we identified 63% of children with lysinuria‐cystinuria, 8% with lysinuric rotein intolerance, and 4% with hypotonia‐cystinuria syndrome.ConclusionManagement of prenatal hyperechoic colon should include a specialized consultation with a clinical geneticist to discuss further investigations, which could include invasive amniotic fluid sampling for molecular diagnosis. A better understanding of diagnoses and prognosis should improve medical counseling and guide parental decision making.