bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eddy-Induced Subsurface Spiciness Anomalies in the Kuroshio Extension Region
Authors: Lv Mingkun , Wang Fan , Li Yuanlong 
Published: December 2023

Abstract
While mesoscale eddy-induced temperature and salinity (T and S) variations at depth levels were widely reported, those on isopycnal surfaces have been largely unexplored so far. This study investigates temperature and salinity anomalies (T′ and S′; dubbed “spiciness anomalies”) on isopycnal surfaces induced by mesoscale eddies in the Kuroshio Extension (KET) region, with a focus on the North Pacific Intermediate Water (NPIW) layer of 26.3–26.7σθ. Cyclonic eddies (CEs) and anticyclonic eddies (AEs) tend to cluster on the northern and southern flanks of the KET jet, respectively. These eddies are characterized by a large radius (CEs: 61.94 km; AEs: 68.05 km), limited zonal movement, and a tendency of meridional movement (CEs: 0.35 cm s−1 southward; AEs: 0.66 cm s−1 northward). The average eddy-induced T′ and S′ are −0.25°C (0.06°C) and −0.05 psu (0.01 psu) for CEs (AEs) in the 26.3–26.7σθ layer. We propose two mechanisms for the generation of subsurface spiciness anomalies, respectively, for moving eddies that travel over long distances with trapped waters and quasi-stationary meander eddies that are generated by the meanders of the KET front. The T′ and S′ induced by moving eddies cumulatively drive cross-front water exchanges. Meander eddies shift the position of the front and induce redistribution of properties. However, these anomalies do not contribute to heat and salt exchanges between water masses. This work provides a useful benchmark for model simulations of mesoscale isopycnal variability in subsurface waters.
Did Residents Stop Operating During COVID? Impact of COVID-19 Across VA Teaching Hospitals on Surgical Resident Education
Authors: Tsui Grace O. , Kunac Anastasia , Oliver Joseph B. , Mehra Shyamin , Anjaria Devashish J. 
Published: December 2023

Background During the COVID-19 pandemic, elective cases across the nation were suspended, leading to major decreases in operative volume for surgical trainees. Surgical resident operative autonomy has been declining over time, so we sought to explore the effect COVID-19 had on resident autonomy within VA teaching hospitals. Methods A retrospective analysis of surgical cases across specialties was performed using the VA Surgical Quality Improvement Program database from September 2019 to September 2021 at VA teaching hospitals. Supervision codes are recorded prospectively: attending surgeon performs the operation (AP), resident completes majority of the case with the attending scrubbed (AR), and resident is primary surgeon without attending scrubbed (RP). Results 20,457 cases pre-COVID decreased to 11,035 during peak-COVID ( P < .001). Overall, RP cases increased from 6.5% to 7.6% during the peak ( P < .001) and trended back downwards during the recovery periods. AP decreased initially (29.9%-27.7%, P < .001), but regressed back to pre-pandemic numbers. In general surgery RP cases, urgent cases such as laparoscopic cholecystectomies increased from 18.8% to 27.5%, while elective repairs decreased during the peak. Similar changes were noted across specialties. Discussion Operative cases dropped by half from pre- to peak- COVID and remained 20% below pre-pandemic volume the following year. Interestingly, RP rates increased for several specialties during the peak of the pandemic, which may have resulted from a relative higher ratio of resident personnel:case volume and shift in case distribution from elective to urgent. The increase in RP rate has begun to regress to pre-COVID levels which need to be readdressed.
Fantasy Sports as Gaming or Gambling? Perception, Attitudes, and Engagement Behavior of College Students
Authors: Balhara Yatan Pal Singh , Gulati Daman Deep Kaur , Rajguru Akanksha Jayant 
Published: December 2023

Background: The current study was carried out owing to the projected increase in the fantasy sports market in India, the popularity of fantasy sports in the age group of 18–25 years, the gambling-related implications of engaging in fantasy sports, and the dearth of published data on the extent and pattern of engagement in fantasy sports among college students in India. We aimed to assess the attributes of engagement in fantasy sports among college students and explore their perceptions and attitudes toward fantasy sports. Methods: This was a cross-sectional observational study among students enrolled in undergraduate courses in an autonomous college in central India. The study questionnaire included a semi-structured proforma that asked for information on the sociodemographic details, questions to assess the gaming (both online and offline) pattern and participation in fantasy sports by the study participants, and a modified Motives for Online Gaming Questionnaire (MOGQ). The participants were also asked to express, on a 10-point scale, their agreement that fantasy sports are similar to gambling. Results: Around one-fifth of the participants had engaged in a fantasy sport at least once. Around 18% had gambled at least once. The participants who reported losing money from fantasy sports also engaged in a significantly greater number of fantasy sports ( p = .002). Those who engaged in fantasy sports with the main goal of making money agreed more with the statement that fantasy sports are similar to online gambling compared to those who did not ( p = .01). Conclusions: Those who engaged in fantasy sports to make money agreed more with the statement that fantasy sports are similar to gambling. The study helps understand the associations between various psychosocial motives, monetary motivations, and involvement in fantasy sports.
Serration Angioplasty Is Associated With Less Recoil in Infrapopliteal Arteries Compared With Plain Balloon Angioplasty
Authors: Fereydooni Arash , Chandra Venita , Schneider Peter A. , Giasolli Robert , Lichtenberg Michael , Stahlhoff Stefan 
Published: December 2023

Purpose: Recoil following balloon angioplasty of tibial arteries is a known mechanism of lumen loss and widely considered to be a contributing factor in early failure or later restenosis. The Serranator balloon has been designed to provide a controlled lumen gain while minimizing vessel injury. The objective of this study was to assess the ability to define and measure postangioplasty recoil in infrapopliteal arteries and to compare recoil after serration angioplasty and plain balloon angioplasty (POBA). Methods: This multi-center, sequential comparative study included patients with de novo or restenotic lesions of infrapopliteal arteries up to 22 cm in length. Patients were enrolled sequentially and underwent alternating POBA or serration angioplasty with Serranator. The study captured angiographic imaging at pre, immediately post, and 15-minute after angioplasty. Vessel recoil, final diameter stenosis, and dissection were compared using core laboratory analysis. Results: This study enrolled 36 patients who underwent treatment of 39 infrapopliteal lesions. There was no significant difference between Serranator (n=20) and POBA (n=19) with respect to baseline demographics and lesion characteristics. Arterial recoil (>10%) occurred in 25% of Serranator-treated lesions versus 64% in POBA-treated lesions (p=0.02. Clinically relevant recoil (>30%) was present after serration angioplasty in 10% of patients and after POBA in 53% (p=0.01). There was no significant difference in technical success (100% for both), dissection rate between Serranator (5%) and POBA (5.2%). Conclusions: Arterial recoil occurs after infrapopliteal angioplasty. Serration angioplasty produces substantially less arterial recoil compared with POBA. Additional studies are needed to assess whether reduced arterial recoil translates into superior long-term clinical outcomes. Clinical Impact Prior studies have demonstrated over 90% recoil in patients after balloon angioplasty (POBA) of the infrapopliteal vessels, which significantly impacts the durability and impact of endovascular interventions in this clinical space. This study compared recoil after infrapopliteal angioplasty with serration angioplasty and POBA. Serration angioplasty produces substantially less arterial recoil compared with POBA. Additional studies are needed to assess whether reduced arterial recoil translates into superior long-term clinical outcomes.
Physical distancing and its association with travel behavior in daily pre-pandemic urban life: An analysis utilizing lifelogging images and composite survey and mobility data
Authors: Thakuriah Piyushimita , Boididou Christina , Hong Jinhyun 
Published: December 2023

This study analyzed physical distancing in people’s daily lives and its association with travel behavior and the use of transportation modes before the COVID-19 outbreak. We used data from photographic images acquired automatically by lifelogging devices every 5 seconds, on average, from 170 participants of a 2-day wearable camera study, in order to identify their physical distancing status throughout the day. Using deep-learning computer vision algorithms, we developed three measures which provided a near-continuous quantification of the proportion of time spent without anyone else within a distance of approximately 13 meters, as well as the proportion of time spent without others within approximately 2 meters. These measures are then used as outcomes in beta regression and multinomial logit models to explore the association between the participant’s physical distancing and travel behavior and transportation choices. The multidisciplinary research approach to understand these associations accounted for a number of social, economic, and cultural factors that potentially influenced their physical isolation levels. We found that participants spend a significant amount of time physically separated from others, without anyone else within 2 meters. The use of public transportation, automobiles, active travel, and an increase in trip frequency, including trips to transportation facilities, reduced the extent of physical distancing, with public transportation having the most significant impact. Higher incomes, strong social networks, and a sense of belonging to the community reduced the tendency for physical distancing. In contrast, factors such as age, obesity, dog ownership, intensive use of the Internet, and being knowledgeable about climate change issues increased the likelihood of physical distancing. The paper addresses a crucial gap in our understanding of how these factors intersect to create the dynamics of physical distancing in non-emergency situations and highlights their planning and operational implications while showcasing the use of unique person-based physical distancing measures derived from autonomously collected image data.
Guangyuanite, Pb3Cl3(Se4+O3)(OH), a new lead chloride selenite mineral from the El Dragón mine, Potosí, Bolivia
Authors: Yang Hexiong , Gu Xiangping , McGlasson James A. , Gibbs Ronald B. , Downs Robert T. 
Published: December 2023

AbstractA new mineral species, guangyuanite, ideally Pb3Cl3(Se4+O3)(OH), was discovered from the El Dragón mine, Antonio Quijarro Province, Potosí Department, Bolivia. It occurs as equant crystals. Associated minerals are Co-bearing krut'aite–penroseite, chalcomenite, schmiederite, olsacherite, phosgenite, anglesite, cerussite and franksousaite. Guangyuanite is pale yellow–brown in transmitted light, transparent with white streak and vitreous lustre. It is brittle and has a Mohs hardness of ~3. No parting or cleavage was observed. The calculated density is 7.63 g/cm3. An electron microprobe analysis yielded an empirical formula [based on 7 (O + Cl) atoms per formula unit] of Pb3.02Cl3.01(Se4+0.99O3)(OH), which can be simplified to Pb3Cl3(Se4+O3)(OH).Guangyuanite is isostructural with synthetic Pb3Br3(Se4+O3)(OH). It is orthorhombic, with space group Pnma and unit-cell parameters a = 11.0003(5), b = 10.6460(5), c = 7.7902 Å, V = 912.31(6) Å3 and Z = 4. The crystal structure of guangyuanite contains two symmetrically-distinct Pb (Pb1 and Pb2) cations, with Pb1 coordinated by eight anions (4O + 4Cl) and Pb2 only by six anions (3O + 3Cl), forming a marked lopsided coordination typical of Pb2+ with a stereochemically active 6s2 lone electron pair. The Se4+ cation forms a typical [Se4+O3] trigonal pyramid. The crystal structure of guangyuanite can be described as consisting of layers of edge-sharing [Pb1O4Cl4] polyhedra parallel to (100). These layers are linked together by sharing polyhedral corners (Cl atoms), as well as [Pb2O3Cl3] and [Se4+O3] groups. Chemically, guangyuanite is one of six lead chloride selenite minerals reported thus far and closely related to orlandiite Pb3Cl4(Se4+O3)⋅H2O.
Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG
Authors: Loo Sun , Roberts Andrew W. , Anstee Natasha S. , Kennedy Glen A. , He Simon , Schwarer Anthony P. , Enjeti Anoop K. , D’Rozario James , Marlton Paula , Bilmon Ian A. , Taper John , Cull Gavin , Tiley Campbell , Verner Emma , Hahn Uwe , Hiwase Devendra K. , Iland Harry J. , Murphy Nick , Ramanathan Sundra , Reynolds John , Ong Doen Ming , Tiong Ing Soo , Wall Meaghan , Murray Michael , Rawling Tristan , Leadbetter Joanna , Rowley Leesa , Latimer Maya , Yuen Sam , Ting Stephen B. , Fong Chun Yew , Morris Kirk , Bajel Ashish , Seymour John F. , Levis Mark J. , Wei Andrew H. 
Published: December 2023

Abstract
Sorafenib maintenance improves outcomes after hematopoietic cell transplant (HCT) for patients with FMS-like tyrosine kinase 3–internal tandem duplication (FLT3-ITD) acute myeloid leukemia (AML). Although promising outcomes have been reported for sorafenib plus intensive chemotherapy, randomized data are limited. This placebo-controlled, phase 2 study (ACTRN12611001112954) randomized 102 patients (aged 18-65 years) 2:1 to sorafenib vs placebo (days 4-10) combined with intensive induction: idarubicin 12 mg/m2 on days 1 to 3 plus either cytarabine 1.5 g/m2 twice daily on days 1, 3, 5, and 7 (18-55 years) or 100 mg/m2 on days 1 to 7 (56-65 years), followed by consolidation and maintenance therapy for 12 months (post-HCT excluded) in newly diagnosed patients with FLT3-ITD AML. Four patients were excluded in a modified intention-to-treat final analysis (3 not commencing therapy and 1 was FLT3-ITD negative). Rates of complete remission (CR)/CR with incomplete hematologic recovery were high in both arms (sorafenib, 78%/9%; placebo, 70%/24%). With 49.1-months median follow-up, the primary end point of event-free survival (EFS) was not improved by sorafenib (2-year EFS 47.9% vs 45.4%; hazard ratio [HR], 0.87; 95% confidence interval [CI], 0.51-1.51; P = .61). Two-year overall survival (OS) was 67% in the sorafenib arm and 58% in the placebo arm (HR, 0.76; 95% CI, 0.42-1.39). For patients who received HCT in first remission, the 2-year OS rates were 84% and 67% in the sorafenib and placebo arms, respectively (HR, 0.45; 95% CI, 0.18-1.12; P = .08). In exploratory analyses, FLT3-ITD measurable residual disease (MRD) negative status (&lt;0.001%) after induction was associated with improved 2-year OS (83% vs 60%; HR, 0.4; 95% CI, 0.17-0.93; P = .028). In conclusion, routine use of pretransplant sorafenib plus chemotherapy in unselected patients with FLT3-ITD AML is not supported by this study.
Purine degradation pathway metabolites at birth and the risk of lower respiratory tract infections in infancy
Authors: Gutierrez Maria J. , Nino Gustavo , Restrepo-Gualteros Sonia , Mondell Ethan , Chorvinsky Elizabeth , Bhattacharya Surajit , Bera Bethlehem Solomon , Welham Allison , Hong Xiumei , Wang Xiaobin 
Published: December 2023

BackgroundLower respiratory tract infections (LRTIs) are the leading cause of infant morbidity and mortality worldwide, and altered metabolite production is recognised as a critical factor in LRTI pathogenesis.MethodsThis study aimed to identify prenatal metabolic changes associated with LRTI risk in infancy, using liquid chromatography-mass spectrometry unbiased metabolomics analysis on cord blood from 810 full-term newborns.ResultsWe identified 22 compounds linked to LRTIs in infancy, enriched for purine degradation pathway (PDP) metabolites. High cord blood PDP metabolites, including xanthine, hypoxanthine, xanthosine and inosine, were linked to reduced LRTI risk during infancy. Notably, a low xanthine to uric acid ratio at birth predicted a four-fold increased LRTI risk.ConclusionThis study is the first to reveal that high cord blood PDP metabolites identify newborns at lower LRTI risk, stratifying disease risk at birth. Moreover, our results prompt further study on PDP enzymes as pharmacological targets to decrease LRTI morbidity and mortality for at-risk newborns.
Reverse shock index (RSI) as a predictor of post-intubation cardiac arrest (PICA)
Authors: Torabi Mehdi , Mahani Ghazal Soleimani , Mirzaee Moghaddameh 
Published: December 2023

AbstractBackgroundEndotracheal intubation (ETI) in critically ill patients is a high-risk procedure due to the increased risk of cardiac arrest, and several factors may predict poor outcomes in these patients. The aim of this study was to investigate the role of some factors, especially newly introduced vital signs such as the reverse shock index (RSI), in predicting post-intubation cardiac arrest (PICA) in critically ill adult patients.MethodsThis cross-sectional study was conducted on critically ill patients over 18 years of age who were admitted to the emergency department (ED) and underwent ETI within 1 year. Patients who developed PICA and those without this event were included in the study, and their features were compared. The primary outcome was cardiac arrest.ResultsOf 394 patients, 127 patients were included, of whom 95 (74.8%) developed PICA, and 32 (25.2%) did not experience cardiac arrest after intubation. In multivariate analysis, age, RSI, oxygen saturation, and total bilirubin were significantly associated with PICA. In addition, patients with RSI < 1 had a significantly higher risk of developing PICA (odds ratio = 5.22, 95% CI 1.83–14.86,p = 0.002). The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for predicting PICA were 51.11%, 83.33%, 90.2%, 36.23%, and 59.17%, respectively. The ROC curve for RSI showed an area under the curve (AUC) of 0.66.ConclusionRSI may be useful in predicting PICA with higher diagnostic accuracy compared to the shock index. Furthermore, advanced age, hypoxia, and hyperbilirubinemia may increase the risk of PICA in patients admitted to the ED.
The draft genome of the Temminck’s tragopan (Tragopan temminckii) with evolutionary implications
Authors: Li Xuejuan , Wang Xiaoyang , Yu Xiaoping , Yang Chao , Lin Liliang , Huang Yuan 
Published: December 2023

Abstract
Background
High-quality genome data of birds play a significant role in the systematic study of their origin and adaptive evolution. The Temminck’s tragopan (Tragopan temminckii) (Galliformes, Phasianidae), a larger pheasant, is one of the most abundant and widely distributed species of the genus Tragopan, and was defined as class II of the list of national key protected wild animals in China. The absence of a sequenced genome has restricted previous evolutionary trait studies of this taxa.

Results
The whole genome of the Temminck’s tragopan was sequenced using Illumina and PacBio platform, and then de novo assembled and annotated. The genome size was 1.06 Gb, with a contig N50 of 4.17 Mb. A total of 117.22 Mb (11.00%) repeat sequences were identified. 16,414 genes were predicted using three methods, with 16,099 (98.08%) annotated as functional genes based on five databases. In addition, comparative genome analyses were conducted across 12 Galliformes species. The results indicated that T. temminckii was the first species to branch off from the clade containing Lophura nycthemera, Phasianus colchicus, Chrysolophus pictus, Syrmaticus mikado, Perdix hodgsoniae, and Meleagris gallopavo, with a corresponding divergence time of 31.43 million years ago (MYA). Expanded gene families associated with immune response and energy metabolism were identified. Genes and pathways associated with plumage color and feather development, immune response, and energy metabolism were found in the list of positively selected genes (PSGs).

Conclusions
A genome draft of the Temminck’s tragopan was reported, genome feature and comparative genome analysis were described, and genes and pathways related to plumage color and feather development, immune response, and energy metabolism were identified. The genomic data of the Temminck’s tragopan considerably contribute to the genome evolution and phylogeny of the genus Tragopan and the whole Galliformes species underlying ecological adaptation strategies.
Gut dysbacteriosis induces expression differences in the adult head transcriptome of Spodoptera frugiperda in a sex-specific manner
Authors: Junrui-Fu  , Rong Zixia , Huang Ximei , Wang Junhan , Long Xiaoyan , Feng Qili , Deng Huimin 
Published: December 2023

AbstractMounting evidence indicates that the gut microbiota influences the neurodevelopment and behavior of insects through the gut-brain axis. However, it is currently unclear whether the gut microbiota affect the head profiles and immune pathway in pests. Here, we find that gut bacteria is essential for the immune and neural development of adult Spodoptera frugiperda, which is an extremely destructive agricultural pest worldwide. 16 S rRNA sequencing analysis showed that antibiotics exposure significantly disturbed the composition and diversity of gut bacteria. Further transcriptomic analysis revealed that the adult head transcripts were greatly affected by gut dysbacteriosis, and differently expression genes critical for brain and neural development including A4galt, Tret1, nsun4, Galt, Mitofilin, SLC2A3, snk, GABRB3, Oamb and SLC6A1 were substantially repressed. Interestingly, the dysbacteriosis caused sex-specific differences in immune response. The mRNA levels of pll (serine/threonine protein kinase Pelle), PGRP (peptidoglycan-sensing receptor), CECA (cecropin A) and CECB (cecropin B) involved in Toll and Imd signaling pathway were drastically decreased in treated male adults’ heads but not in female adults; however, genes of HIVEP2, ZNF131, inducible zinc finger protein 1-like and zinc finger protein 99-like encoding zinc-finger antiviral protein (ZAP) involved in the interferon (IFNα/β) pathway were significantly inhibited in treated female adults’ heads. Collectively, these results demonstrate that gut microbiota may regulate head transcription and impact the S. frugiperda adults’ heads through the immune pathway in a sex-specific manner. Our finding highlights the relationship between the gut microbiota and head immune systems of S. frugiperda adults, which is an astonishing similarity with the discoveries of other animals. Therefore, this is the basis for further research to understand the interactions between hosts and microorganisms via the gut-brain axis in S. frugiperda and other insects.