bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-71 Track recurrence of follicular thyroid carcinoma after transoral endoscopic thyroidectomy vestibular approach
Authors: Oh Moon Young , Chai Young Jun 
Published: January 2024

Abstract

Introduction
While track recurrence of thyroid cancer following endoscopic and robotic transaxillary surgeries has been reported previously, no such cases have been reported for transoral endoscopic thyroidectomy vestibular approach (TOETVA).

Clinical Case
This case report describes the first documented case of recurrence of thyroid cancer along the surgical track after TOETVA. The patient underwent TOETVA to perform a right thyroidectomy for a 4 cm follicular thyroid carcinoma that was initially diagnosed as a benign follicular nodule on preoperative gun biopsy. Ultrasonography and computed tomography conducted 27 months after surgery revealed suspected track recurrence. A re-operation was done in two stages to perform a completion thyroidectomy, bilateral central lymph node dissection, and excision of recurrent nodules, which were pathologically confirmed as metastatic follicular thyroid carcinoma. The patient underwent two treatments of radioactive iodine therapy for remnant thyroid tissues, and post-therapeutic whole-body scintigraphy showed no iodine uptake after the second treatment. Follow-up computed tomography conducted one year after re-operation showed no recurrences. Careful monitoring after TOETVA is essential due to the rare but potential risk of track recurrence. Surgeons should be aware of this atypical complication and be prepared to recommend surgical and/or medical strategies to manage any local seeding of thyroid tissue that may occur.Figure 1.Track recurrence after TOETVA
Overnight 1-mg DST Serum Cortisol in Various Stages of Chronic Kidney Disease—Normative Data and Underlying Mechanisms
Authors: Garg Robin , Memon Saba Samad , Lila Anurag , Sarathi Vijaya , Patil Priyanka , Jamale Tukaram , Bose Sreyashi , Karlekar Manjiri , Patil Virendra , Shah Nalini , Bandgar Tushar 
Published: January 2024

Abstract

Context
Data on the overnight 1 mg-dexamethasone suppression test (ONDST) in renal dysfunction are limited.

Objective
We aim to determine the normative range of ONDST cortisol across chronic kidney disease (CKD) stages and reasons for its alteration.

Methods
Prospectively, 180 CKD (30 each in G2-G5/5D) patients and 30 healthy controls underwent ONDST 8 Am serum cortisol (chemiluminescent immunoassay [CLIA]). In an exploratory cohort, 45 (15 each: G3b/G4, G5/G5D, and healthy controls) individuals’ blood biochemistry for basal (8 Am) cortisol and adrenocorticotropin (ACTH), post-ONDST 8 Am dexamethasone, ACTH, cortisol (CLIA and liquid chromatography–tandem mass spectrometry), and 4 Pm cortisol was collected.

Results
Post-ONDST cortisol (µg/dL) correlated inversely (r = 0.47; P &lt; .005) with estimated glomerular filtration rate (eGFR) (mL/min/1.73 m2), with 95th percentile being 1.2 in controls, 3.0 in G2, 3.2 in G3a, 4.3 in G3b, 4.7 in G4, 5.7 in G5, and 7.1 in G5D. In the exploratory cohort, basal 8 Am cortisol and ACTH, and post-ONDST dexamethasone were similar among controls and CKD subgroups. ONDST ACTH (for evaluating the hypothalamo-pituitary-adrenal axis) was slightly higher in G5/5D vs controls (8.9 vs 6.1 pg/mL), while it was similar in G3b/G4 vs controls. Median 8 Am ONDST cortisol was similar on CLIA and LC-MS/MS in controls and higher on CLIA in G3b/4 (1.7 vs 1.1 µg/dL; P = .012) and G5/5D (2.4 vs 1.7 µg/dL; P = .002) than LC-MS/MS. Post-ONDST serum cortisol drop from 8 Am to 4 Pm was significant in controls (0.5-&lt;0.2 µg/dL) and G3b/4 (1.7-1.2 µg/dL), but not in G5/5D (2.4-2.2 µg/dL).

Conclusion
The normative data of ONDST serum cortisol with eGFR-based cutoffs are useful in evaluating Cushing syndrome in CKD. Prolonged cortisol half-life and immunoassay-related assay cross-reaction are likely contributors to higher ONDST cortisol.
Bovine umbilical vein endothelial cells conditioned medium prevents TMT-induced neurotoxicity mediated by the upregulation of brain-derived neurotropic factors on the human neuroblastoma SH-SY5Y cells
Authors: Saragih Golda Rani , Winarsih Sugi , Wihadmadyatami Hevi , Kusindarta Dwi Liliek 
Published: January 2024

Background: Neurodegenerative diseases are characterized by damage to the central nervous system through the progressive decrease in the structure and function of neurons, followed by neuronal death. Current therapy for these diseases is still limited. Bovine umbilical vein endothelial cells conditioned medium (BUVEC-CM) is a medium harvested from culture of bovine umbilical vein endothelial cells (BUVEC). This study aimed to evaluate the capability of BUVEC-CM to prevent neurotoxicity induced by trimethyltin (TMT) on human neuroblastoma SH-SY5Y cells. Methods: The tests carried out were a viability test with MTT and CCK-8 assay, scratch wound assay to determine cell migration, Hoechst 33342 and AO/PI staining to detect apoptosis, ELISA test to measure the concentration of BDNF, and RT-qPCR to determine the expression of CD68, caspase-7 and caspase-9, and DCFH-DA staining to detect reactive oxygen species (ROS). Results: BUVEC-CM maintained the viability of cells, increase cell migration, prevent cell apoptosis, increase BDNF levels, decrease the expression of CD68, as well as the caspase-7 and -9 genes, and suppress ROS generation. Conclusions: BUVEC-CM can protect from neurodegeneration in SH-SY5Y cells through upregulation of BDNF and downregulation of CD68, caspase-7 and caspase-9.
The impact of the ketogenic diet on the health of patients with Alzheimer’s disease
Authors: Samborska Julia , Więckowiak Paweł , Stelmaszak Karina , Stencel Katarzyna , Ogiegło-Kowalczyk Aleksandra , Wojtasik Monika , Głodzik Michał , Miśkiewicz Marek , Żak Katarzyna , Łęcka Martyna 
Published: January 2024

INTRODUCTION:
Diet is an integral element of every individual's health. Its impact on the functioning of the human body has fascinated scientists for years. One of the diets that alters the mechanism of the body's functioning is the ketogenic diet. The impact of the ketogenic diet on various disorders is still under investigation. It is known to have shown numerous benefits in reducing epileptic seizures, but its impact on other neurological disorders is less known. In this literature review, the efficacy of ketogenic therapies was assessed in Alzheimer's disease.

AIM OF STUDY:
Review of the current literature (since 2018) on the effects of implementing a ketogenic diet in patients with Alzheimer's disease.

MATERIALS AND METHODS:
The review was based on data gathered from the PubMed database using the keywords: 'ketogenic diet in Alzheimer’s disease,' 'ketogenic therapies Alzheimer disease,' and 'ketogenic diet in neurological disease’.

SUMMARY:
The ketogenic diet enhances the daily functioning of Alzheimer's patients. It significantly improves their cognitive functions, and changes in brain blood flow are visible in imaging studies. The ketogenic diet also positively modulates the gut microbiome in Alzheimer's patients. It represents a promising option in combating cognitive symptoms of Alzheimer's disease.
Choclo virus (CHOV) recovered from deep metatranscriptomics of archived frozen tissues in natural history biorepositories
Authors: Salazar-Hamm Paris S. , Johnson William L. , Nofchissey Robert A. , Salazar Jacqueline R. , Gonzalez Publio , Goodfellow Samuel M. , Dunnum Jonathan L. , Bradfute Steven B. , Armién Blas , Cook Joseph A. , Domman Daryl B. , Dinwiddie Darrell L. 
Published: January 2024

Background
Hantaviruses are negative-stranded RNA viruses that can sometimes cause severe disease in humans; however, they are maintained in mammalian host populations without causing harm. In Panama, sigmodontine rodents serve as hosts to transmissible hantaviruses. Due to natural and anthropogenic forces, these rodent populations are having increased contact with humans.

Methods
We extracted RNA and performed Illumina deep metatranscriptomic sequencing on Orthohantavirus seropositive museum tissues from rodents. We acquired sequence reads mapping to Choclo virus (CHOV, Orthohantavirus chocloense) from heart and kidney tissue of a two-decade old frozen museum sample from a Costa Rican pygmy rice rat (Oligoryzomys costaricensis) collected in Panama. Reads mapped to the CHOV reference were assembled and then validated by visualization of the mapped reads against the assembly.

Results
We recovered a 91% complete consensus sequence from a reference-guided assembly to CHOV with an average of 16X coverage. The S and M segments used in our phylogenetic analyses were nearly complete (98% and 99%, respectively). There were 1,199 ambiguous base calls of which 93% were present in the L segment. Our assembled genome varied 1.1% from the CHOV reference sequence resulting in eight nonsynonymous mutations. Further analysis of all publicly available partial S segment sequences support a clear relationship between CHOV clinical cases and O. costaricensis acquired strains.

Conclusions
Viruses occurring at extremely low abundances can be recovered from deep metatranscriptomics of archival tissues housed in research natural history museum biorepositories. Our efforts resulted in the second CHOV genome publicly available. This genomic data is important for future surveillance and diagnostic tools as well as understanding the evolution and pathogenicity of CHOV.
Trends in social determinants of inequality in child undernutrition from the Ethiopian Demographic and Health Surveys, 2005–2016
Authors: Birhanu Frehiwot , Yitbarek Kiddus , Atlantis Evan , Woldie Mirkuzie , Bobo Firew 
Published: January 2024

Background
While child undernutrition has been eliminated in some middle-income countries, it remains highly prevalent in sub-Sahara African (SSA) and South Asian regions, and is disproportionately concentrated among the poor. In this study, we estimated trends in child undernutrition by social determinants and related risks from wealth inequality in Ethiopia, from 2005 to 2016.

Method
We analyzed data from three consecutive surveys (2005, 2011, and 2016) from the Ethiopian Demographic and Health Survey. First, we estimated trends in the prevalence of childhood undernutrition variables (stunting, underweight, and wasting) and social determinants (household wealth status, education level, place of residence, and administrative regions). Then we assessed evidence of undernutrition by wealth-related inequality with concentration curves (visual) and concentration indeces (quantitative). A multilevel mixed-effect Poisson regression model was used to identify predictors of undernutrition variables expressed as covariate-adjusted rate ratios, with 95% confidence intervals (RRs, 95%CI).

Result
A total of 23,934 mother-child pairs were obtained from the three surveys. The average prevalence decreased by 12.4 percentage points for stunting (from 50.8 to 38.4%, P<0.01), 9.5 percentage points for underweight (33.2% to23.7%, P<0.01), and 2.1 percentage points for wasting (12.2% to10.1%, P<0.01). There was persistent and statistically evidence of wealth inequality in stunting, underweight, and wasting (concentration indeces of -0.2 to -0.04, all P values <0.05). Stunting, underweight, and wasting variables were associated with male sex of the child (RR 0.94, 0.95, 0.85, all P-values <0.01) recent diarrhea (RR 1.18, 1.27, 1.37, all P-values <0.01), secondary education status of the mother (RR 0.66, 0.57, 0.61, all P-values < 0.057), increasing wealth index (richest) (RR 0.73, 0.70, 0.50, all P-values < 0.05), and having no toilet facility (RR 1.16, 1.22, 1.18, all P-values < 0.05).

Conclusion
Despite the decreased burden of stunting and underweight, the prevalence of wasting remained relatively unchanged in Ethiopia from 2005 to 2016. Moreover, wealth-related inequality in child undernutrition increased for most of the child undernutrition indicators during this period. Social determinants of child undernutrition warrant urgent implementation of strategies to reduce their health impacts in SSA.
Severe Ulcerative Colitis Complicated by Malakoplakia Resulting in Proctocolectomy
Authors: Alphonsus Lotus , De Silva Theshani A. , Driman David , Jairath Vipul 
Published: January 2024

ABSTRACT
We report a 45-year-old man with medically refractory ulcerative colitis with superimposed colonic malakoplakia, presumed related to chronic use of azathioprine and biologics. This is the first reported case of malakoplakia in a patient requiring high doses of combination therapy. Treatment of malakoplakia is not standardized, but can involve systemic antibiotics, or surgical resection, which in this case resulted in proctocolectomy.
Matrix representations of arbitrary bounded operators on Hilbert spaces
Authors: Müller Vladimir , Tomilov Yuri 
Published: January 2024

Abstract
We show that under natural and quite general
assumptions, a large part of a matrix for a bounded
linear operator on a Hilbert space can be preassigned.
The result is obtained in a more general setting of operator
tuples leading to interesting consequences, e.g., when the tuple
consists of powers of a single operator. We also prove several variants
of this result of independent interest. The paper substantially
extends former research on matrix representations in infinite-dimensional spaces dealing
mainly with prescribing the main diagonals.
Disconnective futures: Uncertainty, unfathomability, and the collapse of narrative crisis management
Authors: Simon Zoltán Boldizsár 
Published: January 2024

AbstractThe article explores the exhaustion of narrative as a cognitive instrument in trying to make sense of the “disconnective futures” of the Anthropocene and runaway technological imaginaries. Having its point of departure in the organic ties between narrative form and modern historical understanding, the article’s argument begins by sketching how the modern idea of a historical process entails constant crises of uncertainty, on the one hand, and functions simultaneously as the manager of the very crises it brings about, on the other. The means of this crisis management consists of crafting historical narratives which tame uncertainty and smooth ruptures in time into deeper continuities. It is this narrative crisis management of establishing connections between past, present, and futures, which breaks down when encountering the temporal disconnections of the Anthropocene and technological prospects. Narrative crisis management was created to attend to crises of uncertainty, but it is inadequate to cope with disconnective futures which are not merely uncertain, but unfathomable. Based on a distinction between uncertainty and unfathomability, the article argues that efforts to project narrative connections over disconnective futures produce cognitive failures, and concludes on a note of potential resolutions, hinting at the development of non-narrative and yet historically-minded cognitive instruments attuned to making sense of temporal disconnections.
Rhythmic Vitality: Traditional Aesthetics and the Theoretical Vision of Contemporary Chinese Film Aesthetics
Authors: Chen Linxia 
Published: January 2024

Abstract
For Chinese films, the ideal of “rhythmic vitality” (气韵生动, Qiyun Shengdong) pursued by traditional aesthetics is of great significance. Traditional Chinese painting and calligraphy stress the pace of flowing (“similar sounds integrate”) and the rhythm of harmony (“different sounds correspond to each other”). Correspondingly, the aesthetic ideal of rhythmic vitality refers to the awareness of life produced by the cinematic medium during its evolution. However, compared with the aesthetic developments that characterize western cinema, Chinese films should not be content with its current approach, which largely disregards this particular aesthetic ideal. Rhythmic vitality originates from a unique national cosmology and methodology, beginning with the resemblances between appearances and spirit and resulting with the “primordial qi” (元气, Yuanqi) that constitutes all living creatures. It signifies the special aesthetic connection between humans and nature, whereby each are subjects of one another and in complete harmony. Arguably, this aesthetic ideal avoids the subject–object dichotomy of western thought that has prevailed since modern times. Additionally, the unique quality of cinema’s rhythmic vitality involves the use of special footage. Practically, through the use of large (small humans in wider landscape), full (the scene), far (the distance), and long-lens cameras for scenarios depicting intense emotion or conflict, cinema may render the holistic ideal of rhythmic vitality.
Global Geopotential Models assessment in Ecuador based on geoid heights and geopotential values
Authors: Carrión José , Flores Fredy , Rodríguez Freddy , Pozo Miguel 
Published: January 2024

Abstract
Since the 1960s, the analysis of disturbed satellite orbits to infer Earth’s gravity field functionals has been an important element in determining the Earth’s gravitational field. The long wavelengths of the gravitational field are recovered through the analysis of non-Keplerian variations in the orbital path of artificial satellites, from their tracking from ground stations (Satellite Laser Ranging, Doppler Orbitography and Radiopositioning Integrated by Satellite, and Precise Range And Range-Rate Equipment), from satellite-to-satellite tracking, or by microwave interferometry. In addition, differences in gravitational acceleration in three mutually orthogonal dimensions can be determined by employing a differential accelerometer carried on artificial satellites (satellite gravity gradiometry, SGG). Satellite gravimetry provides global information (long wavelengths) of the Earth’s gravitational field, which is the fundamental basis for the implementation of Global Geopotential Models (GGMs). The GGMs are one of the key tools for the representation of the Earth’s gravity field and, therefore, for the establishment of a Global Height System (i.e., International Height Reference System), whose fundamental reference surface is defined in terms of a geopotential value. In this study, the validation of high-resolution GGMs (coefficients up to degree 2190) was performed based on their performance in Ecuador by comparing geoid heights estimated by the GGMs with the corresponding values derived from Global Navigation Satellite System/leveling records. Furthermore, geopotential values from the GGMs are compared with the corresponding value obtained for the Ecuadorian Vertical Datum by solving the fixed geodetic boundary value problem. The obtained results indicated that the precision of the high-resolution GGMs does not reach the established requirements for the geopotential computation in the International Height Reference Frame fundamental stations.
An application of Hayashi's inequality in numerical integration
Authors: Heilat Ahmed Salem , Qazza Ahmad , Hatamleh Raed , Saadeh Rania , Alomari Mohammad W. 
Published: January 2024

Abstract
This study systematically develops error estimates tailored to a specific set of general quadrature rules that exclusively incorporate first derivatives. Moreover, it introduces refined versions of select generalized Ostrowski’s type inequalities, enhancing their applicability. Through the skillful application of Hayashi’s celebrated inequality to specific functions, the provided proofs underpin these advancements. Notably, this approach extends its utility to approximate integrals of real functions with bounded first derivatives. Remarkably, it employs Newton-Cotes and Gauss-Legendre quadrature rules, bypassing the need for stringent requirements on higher-order derivatives.
Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
Authors: Mu Lei , Qiu Gang 
Published: January 2024

AbstractPurposeThis study identified subtypes and prognostic signature of stage I and stage II gastric cancer based on neutrophil extracellular trap (NET)-related genes.MethodsThe gene expression data associated with stage I and stage II gastric cancer were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. NET-related genes were obtained from previous reference. Differentially expressed NET-related genes were selected by consensus cluster analysis. The differences in immune infiltration between two subtypes were analyzed. Prognosis-related genes were further screened by univariate Cox regression analysis. Gene Set Enrichment Analysis (GSEA) of prognostic signatures was conducted with clusterprofiler. Finally, a miRNA–mRNA–transcription factor (TF) network was constructed.ResultsTotal 43 differential NET-related genes were obtained and two subtypes were obtained based on these genes. Patients of cluster 2 had a better prognosis compared to cluster 1. Eight types of immune cells were differential in infiltration level between two subtypes. Following univariate Cox regression analysis, two genes of CXC chemokine receptor 4 (CXCR4) and nuclear factor, erythroid 2-like 2 (NFE2L2) significantly related to patient survival were selected. GSEA of single gene revealed thatCXCR4was associated with allograft rejection andNFE2L2was associated with drug metabolism-cytochrome P450. A network with 421 miRNA–mRNA–TF regulatory pairs was constructed.ConclusionThe present study identified two subtypes and a prognostic signature for stage I and stage II gastric cancer based on NET-related genes.
Erosion susceptibility mapping of a loess-covered region using Analytic Hierarchy Process – A case study: Kalat-e-Naderi, northeast Iran
Authors: Nooshin Nokhandan Fatemeh , Ghahraman Kaveh , Horváth Erzsébet 
Published: January 2024

In this study, the Analytic Hierarchy Process (AHP) is applied to generate erosion susceptibility maps in four basins of Kalat-e-Naderi county, namely Archangan, Kalat, Qaratigan, and Chahchaheh basins, situated in northeast Iran. The Kalat-e-Naderi region is characterized by a partial coverage of loess. Given the agricultural significance of loess and its susceptibility to erosion, this research focuses specifically on regions covered by loess. Geographic Information System (GIS) tools, including ArcMap and Quantum Geographic Information System (QGIS), were utilized to facilitate the creation of erosion susceptibility maps. Seven factors, including slope, aspect, elevation, drainage density, lithology, the Normalized Difference Vegetation Index (NDVI), and precipitation were selected for consideration. Recognizing the variability of precipitation and vegetation cover across different seasons, seasonal data for the specified factors were employed. Consequently, erosion susceptibility maps were generated on a seasonal basis. Pairwise comparison tables revealed that precipitation, lithology, and slope emerged as the dominant factors contributing to erosion susceptibility in this region. The resultant maps distinctly delineate basins with higher precipitation values, unresistant lithology (such as loess, characterized by high porosity and permeability), and steeper slopes, exhibiting heightened susceptibility to erosion (Archangan and Kalat basins). The credibility of the research findings was examined through on-site observations. The outcomes of this study may provide pertinent insights for decision-makers and planners. This information can be effectively employed in formulating strategies aimed at conserving soil quality in areas vulnerable to erosion hazards.