bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boosting interpersonal emotion regulation through facial imitation: functional neuroimaging foundations
Authors: Wang Jiazheng , Yang Jiemin , Yang Zhenzhen , Gao Wei , Zhang HeMing , Ji Katherine , Klugah-Brown Benjamin , Yuan JiaJin , Biswal Bharat B 
Published: November 2023

Abstract
Empathic function, which is primarily manifested by facial imitation, is believed to play a pivotal role in interpersonal emotion regulation for mood reinstatement. To explore this association and its neural substrates, we performed a questionnaire survey (study l) to identify the relationship between empathy and interpersonal emotion regulation; and a task-mode fMRI study (study 2) to explore how facial imitation, as a fundamental component of empathic processes, promotes the interpersonal emotion regulation effect. Study 1 showed that affective empathy was positively correlated with interpersonal emotion regulation. Study 2 showed smaller negative emotions in facial imitation interpersonal emotion regulation (subjects imitated experimenter’s smile while followed the interpersonal emotion regulation guidance) than in normal interpersonal emotion regulation (subjects followed the interpersonal emotion regulation guidance) and Watch conditions. Mirror neural system (e.g. inferior frontal gyrus and inferior parietal lobe) and empathy network exhibited greater activations in facial imitation interpersonal emotion regulation compared with normal interpersonal emotion regulation condition. Moreover, facial imitation interpersonal emotion regulation compared with normal interpersonal emotion regulation exhibited increased functional coupling from mirror neural system to empathic and affective networks during interpersonal emotion regulation. Furthermore, the connectivity of the right orbital inferior frontal gyrus–rolandic operculum lobe mediated the association between the accuracy of facial imitation and the interpersonal emotion regulation effect. These results show that the interpersonal emotion regulation effect can be enhanced by the target's facial imitation through increased functional coupling from mirror neural system to empathic and affective neural networks.
Unraveling the universality of chemical fear communication: evidence from behavioral, genetic, and chemical analyses
Authors: de Groot Jasper H B , Haertl Tobias , Loos Helene M , Bachmann Christin , Kontouli Athanasia , Smeets Monique A M 
Published: November 2023

Abstract
Abundant evidence indicates that humans can communicate threat-related information to conspecifics through their body odors. However, prior research has been primarily conducted on Western (WEIRD) samples. In this study, we aimed to investigate whether threat-related information can be transmitted by individuals of East Asian descent who carry a single-nucleotide polymorphism (SNP) 538G → A in the ABCC11 gene, which significantly reduces (noticeable) body odor. To examine this, we recruited 18 self-identified male East Asian AA-homozygotes and 18 self-identified male Western individuals who were carriers of the functional G-allele. We collected samples of their fear-related and neutral body odors. Subsequently, we conducted a double-blind behavioral experiment in which we presented these samples to 69 self-identified female participants of Western Caucasian and East Asian backgrounds. The participants were asked to rate faces that were morphed between expressions of fear and disgust. Notably, despite the “odorless” phenotypical expression of the ABCC11-mutation in East Asians, their fear odor caused a perceptual fear bias in both East Asian and Caucasian receivers. This finding leaves open the possibility of universal fear chemosignaling. Additionally, we conducted exploratory chemical analysis to gain initial insights into the chemical composition of the body odors presented. In a subsequent pre-registered behavioral study (N = 33), we found that exposure to hexadecanoic acid, an abundant compound in the fear and neutral body odor samples, was sufficient to reproduce the observed behavioral effects. While exploratory, these findings provide insight into how specific chemical components can drive chemical fear communication.
Recent Travel and Tuberculosis in Migrants: Data From a Low-Incidence Country
Authors: Schwalb Alvaro , Kayumba Kumvana , Houben Rein M G J , Bothamley Graham H 
Published: November 2023

Abstract
Tuberculosis (TB) incidence rates among migrants are higher than those in low-incidence countries. We evaluated smear-positive, pulmonary TB notifications of foreign-born individuals, comparing time since arrival and time since last return travel to the country of origin. TB incidence suggests a time course consistent with recent infection during travel.
A case report of transcatheter closure of post-Bentall ascending aortic pseudoaneurysm due to coronary button dehiscence
Authors: Lin Huan-Chiu , Lee Yung-Tsai , Yin Wei-Hsian , Wei Jeng 
Published: November 2023

Abstract

Background
Ascending aortic pseudoaneurysm due to coronary button dehiscence is a rare, yet life-threatening complication of reconstructive cardiac surgery. Because of its rare entity, large data are lacking, and therefore, treatment guidelines are missing.

Case summary
We describe a case of a 53-year-old male with a past medical history of ascending aortic aneurysm and severe aortic regurgitation who underwent Bentall procedure with 26 mm conduit and mechanical aortic valve 1 year before. Follow-up chest computed tomography (CT) revealed coronary button dehiscence with a giant aortic root pseudoaneurysm and mural thrombus inside. Given the risk of rupture, the heart team decided to go for a percutaneous approach. Based on a pre-interventional 3D reconstructed CT scan and guided by transoesophageal echocardiography and intravascular ultrasound, the pseudoaneurysm was successfully occluded with a 6 × 4 mm Amplatzer Duct Occluder II and simultaneous left main coronary artery (LMCA) stenting with a 4.0 × 15 mm drug-eluting stent. Post-procedural chest CT and echocardiography revealed minimal contrast leakage posterior to the aortic root and para LMCA region, confirmed thrombosis formation post occluder and stent deployment, and patent flow of LMCA.

Discussion
We describe the successful 3D reconstructed CT scan and peri-procedural transoesophageal echocardiography–guided percutaneous treatment of a giant aortic root pseudoaneurysm with an occluder and a drug-eluting stent with excellent results.
Quantifying uncertainties in greenhouse gas savings and abatement costs with cellulosic biofuels
Authors: Lee Yuanyao , Khanna Madhu , Chen Luoye , Shi Rui , Guest Jeremy , Blanc-Betes Elena , Jiang Chongya , Guan Kaiyu , Hudiburg Tara , De Lucia Evan H 
Published: November 2023

Abstract
Cellulosic biofuels from non-food feedstocks, while appealing, continue to encounter uncertainty about their induced land use change (ILUC) effects, net greenhouse gas (GHG) saving potential and their economic costs. We analyse the implications of multiple uncertainties along the biofuel supply chain from feedstock yields, land availability for production to conversion to fuel in the refinery on these outcomes. We find that compared to corn ethanol, cellulosic biofuels have a substantially smaller and less uncertain ILUC-related GHG intensity and lead to larger GHG savings at lower welfare costs of abatement, indicating the potential to make robust and substantial contributions to cost-effective climate change mitigation.
Platelet biology and function: plaque erosion vs. rupture
Authors: Baaten Constance C F M J , Nagy Magdolna , Bergmeier Wolfgang , Spronk Henri M H , van der Meijden Paola E J 
Published: November 2023

Abstract
The leading cause of heart disease in developed countries is coronary atherosclerosis, which is not simply a result of ageing but a chronic inflammatory process that can lead to acute clinical events upon atherosclerotic plaque rupture or erosion and arterial thrombus formation. The composition and location of atherosclerotic plaques determine the phenotype of the lesion and whether it is more likely to rupture or to erode. Although plaque rupture and erosion both initiate platelet activation on the exposed vascular surface, the contribution of platelets to thrombus formation differs between the two phenotypes. In this review, plaque phenotype is discussed in relation to thrombus composition, and an overview of important mediators (haemodynamics, matrix components, and soluble factors) in plaque-induced platelet activation is given. As thrombus formation on disrupted plaques does not necessarily result in complete vessel occlusion, plaque healing can occur. Therefore, the latest findings on plaque healing and the potential role of platelets in this process are summarized. Finally, the clinical need for more effective antithrombotic agents is highlighted.
Amiodarone and pulmonary toxicity in atrial fibrillation: a nationwide Israeli study
Authors: Tsaban Gal , Ostrovsky Daniel , Alnsasra Hilmi , Burrack Nitzan , Gordon Michal , Babayev Amit Shira , Omari Yara , Kezerle Louise , Shamia David , Bereza Sergey , Konstantino Yuval , Haim Moti 
Published: November 2023

Abstract

Background and Aims
Amiodarone-related interstitial lung disease (ILD) is the most severe adverse effect of amiodarone treatment. Most data on amiodarone-related ILD are derived from periods when amiodarone was given at higher doses than currently used.

Methods
A nationwide population-based study was conducted among patients with incident atrial fibrillation (AF) between 1 December 1999 and 31 December 31 2021. Amiodarone-exposed patients were matched 1:1 with controls unexposed to amiodarone based on age, sex, ethnicity, and AF diagnosis duration. The final patient cohort included only matched pairs where amiodarone therapy was consistent throughout follow-up. Directed acyclic graphs and inverse probability treatment weighting (IPTW) modelling were used. Patients with either prior ILD or primary lung cancer (PLC) were excluded. The primary outcome was the incidence of any ILD. Secondary endpoints were death and PLC.

Results
The final cohort included 6039 amiodarone-exposed patients who were matched with unexposed controls. The median age was 73.3 years, and 51.6% were women. After a mean follow-up of 4.2 years, ILD occurred in 242 (2.0%) patients. After IPTW, amiodarone exposure was not significantly associated with ILD [hazard ratio (HR): 1.45, 95% confidence interval (CI): 0.97, 2.44, P = 0.09]. There was a trivial higher relative risk of ILD among amiodarone-exposed patients between Years 2 and 8 of follow-up [maximal risk ratio (RR): 1.019]. Primary lung cancer occurred in 97 (0.8%) patients. After IPTW, amiodarone was not associated with PLC (HR: 1.18, 95% CI: 0.76, 2.08, P = 0.53). All-cause death occurred in 2185 (18.1%) patients. After IPTW, amiodarone was associated with reduced mortality risk (HR: 0.65, 95% CI: 0.60, 0.72, P &lt; 0.001). The results were consistent across a variety of sensitivity analyses.

Conclusion
In a contemporary AF population, low-dose amiodarone was associated with a trend towards increased risk of ILD (15%-45%) but a clinically negligible change in absolute risk (maximum of 1.8%), no increased risk of PLC, and a lower risk of all-cause mortality.
Sleep Disorders and Cognitive Aging Among Cognitively Impaired Versus Unimpaired Older Adults
Authors: Lee Soomi , Nelson Monica E , Hamada Fumiko , Wallace Meredith L , Andel Ross , Buxton Orfeu M , Almeida David M , Lyketsos Constantine , Small Brent J 
Published: November 2023

Abstract

Background and Objectives
Sleep disorders often predict or co-occur with cognitive decline. Yet, little is known about how the relationship unfolds among older adults at risk for cognitive decline. To examine the associations of sleep disorders with cognitive decline in older adults with unimpaired cognition or impaired cognition (mild cognitive impairment and dementia).

Research Design and Methods
A total of 5,822 participants (Mage = 70) of the National Alzheimer’s Coordinating Center database with unimpaired or impaired cognition were followed for 3 subsequent waves. Four types of clinician-diagnosed sleep disorders were reported: sleep apnea, hyposomnia/insomnia, REM sleep behavior disorder, or “other.” Cognition over time was measured by the Montreal Cognitive Assessment (MoCA) or an estimate of general cognitive ability (GCA) derived from scores based on 12 neuropsychological tests. Growth curve models were estimated adjusting for covariates.

Results
In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b = 0.65, 95% confidence interval [95% CI] = [0.07, 1.23]) and less decline in GCA over time (b = 0.06, 95% CI = [0.001, 0.12]). Baseline insomnia was related to better baseline MoCA (b = 1.54, 95% CI = [0.88, 2.21]) and less decline in MoCA over time (b = 0.56, 95% CI = [0.20, 0.92]). Furthermore, having more sleep disorders (across the 4 types) at baseline predicted better baseline MoCA and GCA, and less decline in MoCA and GCA over time. These results were only found in those with impaired cognition and generally consistent when using self-reported symptoms of sleep apnea or insomnia.

Discussion and Implications
Participants with sleep disorder diagnoses may have better access to healthcare, which may help maintain cognition through improved sleep.
Online health information-seeking behaviour and mental well-being among Finnish higher education students during COVID-19
Authors: Rouvinen Hanna , Turunen Hannele , Lindfors Pirjo , Kinnunen Jaana M , Rimpelä Arja , Koivusilta Leena , Kulmala Markus , Dadaczynski Kevin , Okan Orkan , Sormunen Marjorita 
Published: November 2023

Abstract
Online health information-seeking behaviour has increased since the World Health Organization declared COVID-19 a global pandemic in March 2020. This study examined whether health-related information on COVID-19 searched on the internet was associated with mental well-being among higher education students. A cross-sectional internet survey was conducted among 18- to 34-year-old students in Finland (N = 2976; mean age 24.61 years and median 24) in the spring of 2020. The data were analysed using descriptive statistics, Pearson’s chi-square tests, Kruskal–Wallis nonparametric H tests, and a two-way ANOVA. The results indicated that most students (86% of females, 82% of males) used the internet to search for information on COVID-19. Students’ self-perceived abilities to determine the relevance of online information on COVID-19 were associated with mental well-being.
Pan-cancer scRNA-seq analysis reveals immunological and diagnostic significance of the peripheral blood mononuclear cells
Authors: Zhang Yuanhang , Zhou Xiaorui , Zhong Yu , Chen Xi , Li Zeyu , Li Rui , Qin Pengfei , Wang Shanshan , Yin Jianhua , Liu Shang , Jiang Miaomiao , Yu Qichao , Hou Yong , Liu Shiping , Wu Liang 
Published: November 2023

Abstract
Peripheral blood mononuclear cells (PBMCs) reflect systemic immune response during cancer progression. However, a comprehensive understanding of the composition and function of PBMCs in cancer patients is lacking, and the potential of these features to assist cancer diagnosis is also unclear. Here, the compositional and status differences between cancer patients and healthy donors in PBMCs were investigated by single-cell RNA sequencing (scRNA-seq), involving 262,025 PBMCs from 68 cancer samples and 14 healthy samples. We observed an enhanced activation and differentiation of most immune subsets in cancer patients, along with reduction of naïve T cells, expansion of macrophages, impairment of NK cells and myeloid cells, as well as tumor promotion and immunosuppression. Based on characteristics including differential cell type abundances and/or hub genes identified from weight gene co-expression network analysis (WGCNA) modules of each major cell type, we applied logistic regression to construct cancer diagnosis models. Furthermore, we found that the above models can distinguish cancer patients and healthy donors with high sensitivity. Our study provided new insights into using the features of PBMCs in non-invasive cancer diagnosis.
Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants
Authors: Allen James P , Garber Kathryn B , Perszyk Riley , Khayat Cara T , Kell Steven A , Kaneko Maki , Quindipan Catherine , Saitta Sulagna , Ladda Roger L , Hewson Stacy , Inbar-Feigenberg Michal , Prasad Chitra , Prasad Asuri N , Olewiler Leah , Mu Weiyi , Rosenthal Liana S , Scala Marcello , Striano Pasquale , Zara Federico , McCullock Tyler W , Jauss Robin-Tobias , Lemke Johannes R , MacLean David M , Zhu Cheng , Yuan Hongjie , Myers Scott J , Traynelis Stephen F 
Published: November 2023

Abstract
GRID1 and GRID2 encode the enigmatic GluD1 and GluD2 proteins, which form tetrameric receptors that play important roles in synapse organization and development of the central nervous system. Variation in these genes has been implicated in neurodevelopmental phenotypes. We evaluated GRID1 and GRID2 human variants from the literature, ClinVar, and clinical laboratories and found that many of these variants reside in intolerant domains, including the amino terminal domain of both GRID1 and GRID2. Other conserved regions, such as the M3 transmembrane domain, show different intolerance between GRID1 and GRID2. We introduced these variants into GluD1 and GluD2 cDNA and performed electrophysiological and biochemical assays to investigate the mechanisms of dysfunction of GRID1/2 variants. One variant in the GRID1 distal amino terminal domain resides at a position predicted to interact with Cbln2/Cbln4, and the variant disrupts complex formation between GluD1 and Cbln2, which could perturb its role in synapse organization. We also discovered that, like the lurcher mutation (GluD2-A654T), other rare variants in the GRID2 M3 domain create constitutively active receptors that share similar pathogenic phenotypes. We also found that the SCHEMA schizophrenia M3 variant GluD1-A650T produced constitutively active receptors. We tested a variety of compounds for their ability to inhibit constitutive currents of GluD receptor variants and found that pentamidine potently inhibited GluD2-T649A constitutive channels (IC50 50 nM). These results identify regions of intolerance to variation in the GRID genes, illustrate the functional consequences of GRID1 and GRID2 variants, and suggest how these receptors function normally and in disease.
Does the atrial incision affect rates of early postoperative atrial arrhythmias in mitral valve surgery?
Authors: Bowers Philippa Jane Temple , Ch’ng Stephanie 
Published: November 2023

Summary
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was ‘in patients undergoing mitral valve surgery, does atrial incision affect early postoperative rates of atrial arrhythmia’. Two hundred and four papers were found. Nine represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Data suggest that a transeptal incision is associated with increased rates of postoperative atrial arrhythmia compared with direct left atriotomy.
Deciphering the pivotal role of people with high-frequency occupational animal exposure in antibiotic resistance transmission between humans and animals
Authors: Li Juan , Song Yuqin , Deng Jianping , Wang Zhaoran , Wong Nai-Kei , Wang Chao , Zhang Gang , Wang Yang , Lu Shan , Che Jie , Zhao Xiaofei , Zhang ZhengDong , Wang Hong , Zhang Ling , Zhang YunFei , Bai Xuemei , Yuan Min , Chen Xia , Zhang Wen , Xiong Yanwen , Kan Biao , Feng Jie 
Published: November 2023

Abstract

Background
The spread of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) among humans and food-producing animals has been widely reported. However, the transmission routes and associated risk factors remain incompletely understood.

Methods
Here, we used commensal Escherichia coli bacteria strains from faeces of pigs and local citizens [HEG: high exposure group (pig breeders, butchers or restaurant chefs) and LEG: low exposure group (other occupations)] to explore the dynamics of ARB and ARG transmission between animals and humans.

Results
Most ARGs (96%) present in pigs were shared with humans. Carriage rates of the shared ARGs suggest two transmission patterns among pigs, the HEG and LEG: one pattern was highest in pigs, gradually decreasing in the HEG and LEG (e.g. floR and cmlA1); the other pattern was increasing from pigs to the HEG but then decreasing in the LEG (e.g. mcr-1.1). Carriage rates of the HEG were higher than in the LEG in both patterns, implicating the HEG as a crucial medium in transmitting ARB and ARGs between food-producing animals and humans. Moreover, frequent inter/intragroup transmission via strains, plasmids and/or mobile elements was evident. Carriage of mcr-1.1 on human-gut-prevalent plasmids possibly promoted its enrichment in the HEG.

Conclusions
The HEG is a crucial factor in transmitting ARB and ARGs between food-producing animals and humans. Rational measures to contain the risks of occupational exposure are urgently needed to keep dissemination of antibiotic resistance in check and safeguard public health.
Costs associated with invasive Scedosporium and Lomentospora prolificans infections: a case-control study
Authors: Neoh Chin Fen , Chen Sharon C A , Kong David C M , Hamilton Kate , Nguyen Quoc A , Spelman Tim , Tew Michelle , Harvey Emma L , Ho Su Ann , Saunders Natalie R , Tennakoon Surekha , Crowe Amy , Marriott Debbie , Trubiano Jason A , Slavin Monica A 
Published: November 2023

Abstract

Background
Little is known about the short- and long-term healthcare costs of invasive Scedosporium/Lomentospora prolificans infections, particularly in patient groups without haematological malignancy. This study investigated excess index hospitalization costs and cumulative costs of these infections. The predictors of excess cost and length of stay (LOS) of index hospitalization were determined. These estimates serve as valuable inputs for cost-effectiveness models of novel antifungal agents.

Methods
A retrospective case-control study was conducted at six Australian hospitals. Cases of proven/probable invasive Scedosporium/L. prolificans infections between 2011 and 2021 (n = 34) were matched with controls (n = 66) by predefined criteria. Cost data were retrieved from activity-based costing systems and analysis was performed from the Australian public hospital perspective. All costs were presented in 2022 Australian dollars (AUD). Median regression analysis was used to adjust excess costs of index hospitalization whereas cumulative costs up to 1.5 years follow-up were estimated using interval-partitioned survival probabilities.

Results
Invasive Scedosporium/L. prolificans infections were independently associated with an adjusted median excess cost of AUD36 422 (P = 0.003) and LOS of 16.27 days (P &lt; 0.001) during index hospitalization. Inpatient stay was the major cost driver (42.7%), followed by pharmacy cost, of which antifungal agents comprised 23.8% of the total cost. Allogeneic haematopoietic stem cell transplant increased the excess cost (P = 0.013) and prolonged LOS (P &lt; 0.001) whereas inpatient death within ≤28 days reduced both cost (P = 0.001) and LOS (P &lt; 0.001). The median cumulative cost increased substantially to AUD203 292 over 1.5 years in cases with Scedosporium/L. prolificans infections.

Conclusions
The economic burden associated with invasive Scedosporium/L. prolificans infections is substantial.