bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cobalt on Lifetime of Sb4O5Cl2‐Graphene Anode in Chloride‐Ion Batteries
Authors: Shen Kefan , Lu Xiaoxiao , Shen Shenghui , Xu Panpan , Zeng Yunhui , Li Luying , Cai Yurong , Jia Wenbo , Wang Hong 
Published: December 2023

AbstractAnode materials based on metal oxychlorides hold promise in addressing electrode dissolution challenges in aqueous‐based chloride ion batteries (CIBs). However, their structural instability following chloride ion deintercalation can lead to rapid degradation and capacity fading. This paper investigates a cobalt‐doped Sb4O5Cl2‐graphene (Co‐Sb4O5Cl2@GO) composite anode for aqueous‐based CIBs. It exhibits significantly enhanced discharge capacity of 82.3 mAh g−1 after 200 cycles at 0.3 A g−1; while, the undoped comparison is only 23.5 mAh g−1 in the same condition. It also demonstrated with a long‐term capacity retention of 72.8 % after 1000 cycles (65.5 mAh g−1) and a favorable rate performance of 25 mAh g−1 at a high current density of 2 A g−1. Undertaken comprehensive studies via in‐situ experiments and DFT calculations, the cobalt (Co) dopant is demonstrated as the crucial role to enhance the lifetime of Sb4O5Cl2‐based anodes. It is found that, the Co dopant improves electronic conductivity and the diffusion of chloride ions beside increases the structural stability of Sb4O5Cl2 crystal. Thus, this element doping strategy holds promise for advancing the field of Sb4O5Cl2‐based anodes for aqueous‐based CIBs, and insights gain from this study also offer valuable knowledge to develop high‐performance electrode materials for electrochemical deionization.
An efficient task offloading strategy based on Aquila Student Psychology Optimization Algorithm in internet of vehicles‐fog computing systems
Authors: Lohat Savita , Jain Sheilza , Kumar Rajender 
Published: December 2023

SummaryInternet of vehicles (IoV) comprises connected vehicles and connected autonomous vehicles and offers numerous benefits for ensuring traffic and safety competence. Several IoV applications are delay‐sensitive and need resources for computation and data storage that are not provided by vehicles. Therefore, these tasks are always offloaded to highly powerful nodes, namely, fog, which can bring resources nearer to the networking edges, reducing both traffic congestion and load. Besides, the mechanism of offloading the tasks to the fog nodes in terms of delay, computing power, and completion time remains still as an open concern. Hence, an efficient task offloading strategy, named Aquila Student Psychology Optimization Algorithm (ASPOA), is developed for offloading the IoV tasks in a fog setting in terms of the objectives, such as delay, computing power, and completion time. The devised optimization algorithm, known as ASPOA, is the incorporation of Aquila Optimizer (AO) and Student Psychology Based Optimization (SPBO). Task offloading in the IoV‐fog system selects suitable resources for executing the tasks of the vehicles by considering several constraints and parameters to satisfy the user requirements. The simulation outcomes have shown that the devised ASPOA‐based task offloading method has achieved better performance by achieving a minimum delay of 0.0009 s, minimum computing power of 8.884 W, and minimum completion time of 0.441 s.
Performance of non‐formalin fixed paraffin embedded samples in hybrid capture and amplicon next‐generation sequencing panels
Authors: Meireles Sibele Inácio , Cruz Mariana Vargas , de Godoy Carla Daniele , de Testagrossa Leonardo 
Published: December 2023

AbstractBackgroundGenomic profiling using next‐generation sequencing (NGS) is fundamental for driving prognostic and therapy in cancer. Formalin‐fixed paraffin embedded (FFPE) tissue is the widely used material, whereas non‐FFPE may represent an alternative. However, studies comparing the NGS performance of non‐FFPE materials to FFPE are still lacking in the literature. The objective of this study was to characterize in non‐FFPE preparations the nucleic acid yield and NGS performance on both a capture‐based and an amplicon‐based NGS platform. NGS quality metrics obtained from non‐FFPE preparations were compared to FFPE.MethodsWe analyzed the cellularity and nucleic acid yield in 111 tumors from non‐FFPE preparations. In addition, comprehensive hybrid capture panel sequencing metrics obtained from DNA and RNA libraries were compared between independent non‐FFPE and FFPE samples. A paired comparison between non‐FFPE and FFPE samples was performed to analyze concordance in mutant allele detection using an amplicon panel.ResultsThe mean target coverage from DNA libraries was 2× higher in non‐FFPE samples than in FFPE. The detection of exogenous DNA was 2.5× higher in non‐FFPE than in FFPE. Conversely, a lower performance was observed in non‐FFPE RNA libraries in comparison to FFPE DNA libraries with no impact in minimum standard cutoffs. The variant allele detection in non‐FFPE was found to be comparable to that of FFPE tumor samples in matched samples.ConclusionsNon‐FFPE was demonstrated to be a suitable material for DNA and RNA library preparations using a comprehensive NGS panel. This is the first study reporting library quality metrics according to the TSO500 analysis pipeline.
Valproate treatment induces age‐ and sex‐dependent neuronal activity changes according to a patch clamp study
Authors: Májer Tímea , Bódi Veronika , Kelemen Viktor , Szűcs Attila , Varró Petra , Világi Ildikó 
Published: December 2023

AbstractAutism spectrum disorder is a heterogeneous neurodevelopmental disorder characterized by impaired social interactions, restricted, and stereotyped behaviors. The valproic acid model is one of the most recognized and broadly used models in rats to induce core symptoms of this disorder. Comorbidity of epilepsy and autism occurs frequently, due to similar background mechanisms that include the imbalance of excitation and inhibition. In this series of experiments, treatment was performed on rat dams with a single 500 mg/kg dose i.p. valproate injection on embryonic day 12.5. Intracellular whole‐cell patch clamp recordings were performed on brain slices prepared from adolescent and adult offspring of both sexes on pyramidal neurons of the medial prefrontal cortex and entorhinal cortex. Current clamp stimulation utilizing conventional current step protocols and dynamic clamp stimulation were applied to assess neuronal excitability. Membrane properties and spiking characteristics of layer II–III pyramidal cells were analyzed in both cortical regions. Significant sex‐dependent and age‐dependent differences were found in several parameters in the control groups. Considering membrane resistance, rheobase, voltage sag slope, and afterdepolarization slope, we observed notable changes mainly in the female groups. Valproate treatment seemed to enhance these differences and increase network excitability. However, it is possible that compensatory mechanisms took place during the maturation of the network while reaching the age‐group of 3 months. Based on the results, the expression of the hyperpolarization‐activated cyclic nucleotide‐gated channels may be appreciably affected by the valproate treatment, which influences fundamental electrophysiological properties of the neurons such as the voltage sag. Remarkable changes appeared in the prefrontal cortex; however, also the entorhinal cortex shows similar tendencies.
We need to be more critical toward digital interventions for eating disorders: A commentary on McClure et al. (2023)
Authors: Bauer Stephanie , Moessner Markus 
Published: December 2023

AbstractOver the past two decades, numerous digital interventions (also referred to as “e‐mental health” interventions) have been developed for the prevention and treatment of eating disorders and several meta‐analyses have summarized the existing evidence on the efficacy and effectiveness of such interventions. Based on the present systematic review of McClure and Colleagues, the question of how and for whom digital interventions for eating disorders actually work, remains unanswered. In the absence of reliable mediators and moderators of outcome, priorities for future research are discussed (e.g., a need for more rigorous RCTs with credible comparators). The resulting research agenda is expansive. However, even though this process will take time and might seem slow (especially, in contrast to the rapidity of technological developments), we should not accept a lowering of the quality bar in research on digital interventions compared to other intervention research.
Mixed Thioether/Amine‐Functionalized Expanded Calixarenes, Related Macropolycycles, and Metal Complexes thereof
Authors: Taut Josef , Schleife Frederik , Börner Martin , Bonnot Clément , Jacquot de Rouville Henri‐Pierre , Chambron Jean‐Claude , Kersting Berthold 
Published: December 2023

AbstractA series of tetraaza‐expanded calix[4]arene analogues (2–4), in which two of the four aryl groups are ethylene‐protected thiophenol components were prepared from tetraaldehyde 1. Two of these strapped macrocycles were characterized crystallographically, as well as the dipalladium complex of 4. The same tetraaldehyde had been previously used for the synthesis of a macrotricycle (5) and a macropentacycle (6), the coordination properties of which have been investigated. In particular, ligand 6 was shown to be able to encapsulate a Cu+ or a Ag+ ion in the tetrahedral coordination pocket offered by a bridgehead nitrogen atom and the three proximal thioether sulfur atoms.
Smart h‐Chain: A blockchain based healthcare framework with insurance fraud detection
Authors: Mahapatra Sourav , Sinha Ditipriya 
Published: December 2023

AbstractIn today's smart applications, very frequently used data like electronic health records (EHR's) are highly sensitive and soft target to the unauthorized agencies. Data management, integrity, and security issues plague EHR systems. Insurance firms are prohibited by law and corporate privacy from sharing patient data, but because the data are not linked and synchronized among insurance providers, there has been a rise in healthcare fraud. A crucial component of an e‐health system is safe communication between patients, healthcare providers, and insurance companies. Building a system to securely manage and track insurance operations by combining data from all sources is required to combat health insurance fraud. Over time, blockchain grew in popularity, and the healthcare sector's interest in it led to the development of design concepts that addressed security issues. In this study, a blockchain‐based security architecture has been presented to protect the EHR and provide a secure method for patients, their caregivers, physicians, and insurance agents to access the clinical data of the patients. By using off‐chain storage and cryptographic key exchange through blockchain our approach also covers the scalability, integrity and access control issue that a healthcare system in general is facing.A crucial component of an e‐health system is safe communication between patients, healthcare providers, and insurance companies. A blockchain‐based security architecture has been presented to protect the EHR and provide a secure method for patients, caregivers, physicians, and insurance agents to access the clinical data of the patients.
Monodopsis subterranea is a source of α‐tocomonoenol, and its concentration, in contrast to α‐tocopherol, is not affected by nitrogen depletion
Authors: Montoya‐Arroyo Alexander , Muñoz‐González Alejandra , Lehnert Katja , Frick Konstantin , Schmid‐Staiger Ulrike , Vetter Walter , Frank Jan 
Published: December 2023

Abstractα‐Tomonoenols (αT1) are tocochromanols structurally related to tocopherols (T) and tocotrienols (T3), the bioactive members of the vitamin E family. However, limited evidence exists regarding the sources and biosynthesis of tocomonoenols. Nitrogen depletion increases the content of α‐tocopherol (αT), the main vitamin E congener, in microalgae, but little is known regarding its effect on other tocochromanols, such as tocomonoenols and tocotrienols. We therefore quantified the concentrations of T, T1, and T3, in freeze‐dried biomass from nitrogen‐sufficient, and nitrogen‐depleted Monodopsis subterranea (Eustigmatophyceae). The identities of isomers of αT1 were confirmed by LC–MS and GC–MS. αT was the predominant tocochromanol (82% of total tocochromanols). αT1 was present in higher quantities than the sum of all T3 (6% vs. 1% of total tocochromanols). 11′‐αT1 was the main αT1 isomer. Nitrogen depletion increased αT, but not αT1 or T3 in M. subterranea. In conclusion, nitrogen depletion increased the content of αT, the biologically most active form of vitamin E, in M. subterranea without affecting αT1 and T3 and could potentially be used as a strategy to enhance its nutritional value but not to increase αT1 content, indicating that αT1 accumulation is independent of that of αT in microalgae.
The bidirectional relationship between emotion regulation and social communication in childhood: A systematic review
Authors: Raza Sarah , Sacrey Lori‐Ann R. , Zwaigenbaum Lonnie 
Published: December 2023

AbstractEmotion regulation (ER) refers to the ability to regulate emotional reactions in response to stimuli. Social communication involves the knowledge and skills to engage in social interactions. Both processes develop in the first years of life and form the foundation for later functioning. Literature suggests a bidirectional relationship between ER and social communication; however, the majority of research examines these constructs independently. This review provides an in‐depth examination of research that has measured the relations between ER and social communication in children from 2 years of age and onwards. Findings revealed an age‐related pattern, where ER was related to later social communication and vice versa. However, there was no consensus regarding direct relationship(s) between ER and social communication due to heterogeneity among studies when defining and measuring these constructs. This review illustrates the importance of understanding the pathways between ER and social communication and may inform future studies, both in typical and atypical development.
Time trends of 16 modifiable risk factors on the burden of major cancers among the Chinese population
Authors: Li Jia , Song Xuemei , Ni Yuxin , Zhu Sijia , Chen Weiyi , Zhao Yingying , Yi Jing , Xia Lu , Nie Shaofa , Shang Qinggang , Liu Li 
Published: December 2023

AbstractThe cancer burden in China is increasing. We aimed to assess the time trends in the prevalence of 16 modifiable risk factors involved in lifestyle, diet, infection, and air pollution between 1997 and 2025 based on the China Health and Nutrition Survey, the Global Burden of Disease website, and publically available studies. The population attributable fraction (PAF) and its 95% uncertainty interval (UI) from 2007 to 2035 were calculated to quantify the attributable cancer burden in major 12 anatomic sites using the comparative risk assessment method, considering a 10‐year lag effect. As a result, 1,559,476 cancer cases (PAF = 54.1%, 95% UI: 36.8%–65.8%) from the 12 anatomic sites were attributable to these modifiable risk factors in 2007, with lung, liver, and gastric cancer raging the top three. It was predicted that by 2035, the attributable cancer cases would reach 1,680,098 (PAF = 44.2%, 95% UI: 29.1%–55.5%), with the top three of lung, liver, and colorectal cancer. Smoking, physical inactivity, insufficient fruit consumption, HBV infection, and Helicobacter pylori infection were the most attributable risk factors in 2007, contributing to 480,352, 233,684, 215,009, 214,455, and 187,305 associated cancer cases, respectively. In 2035, the leading factors for cancer would be smoking, physical inactivity, insufficient fruit intake, HPV infection, and HBV infection, resulting in 427,445, 424,327, 185,144, 156,535, and 154,368 cancer cases, respectively. Intervention strategies should be swiftly established and dynamically altered in response to risk factors like smoking, physical inactivity, poor fruit intake, and infectious factors that may cause a high cancer burden in the Chinese population.
A deep learning‐basedx‐rayimaging diagnosis system for classification of tuberculosis,COVID‐19, and pneumonia traits using evolutionary algorithm
Authors: Ali Zeeshan , Khan Muhammad Attique , Hamza Ameer , Alzahrani Ahmed Ibrahim , Alalwan Nasser , Shabaz Mohammad , Khan Faheem 
Published: December 2023

AbstractTo aid in detection of tuberculosis, researchers have concentrated on developing computer‐aided diagnostic technologies based on x‐ray imaging. Since it generates noninvasive standard‐of‐care data, a chest x‐ray image is one of the most often used diagnostic imaging modalities in computer‐aided solutions. Due to their significant interclass similarities and low intra‐class variation abnormalities, chest x‐ray pictures continue to pose difficulty for proper diagnosis. In this paper, a novel automated framework is proposed for the classification of tuberculosis, COVID‐19, and pneumonia from chest x‐ray images using deep learning and improved optimization technique. Two pre‐trained convolutional neural network models such as EfficientB0 and ResNet50 have been utilized and fine‐tuned based on the additional layers. Both models are trained with fixed hyperparameters on the selected datasets and obtained newly trained models. A novel feature selection technique has been proposed that selects the best features. In the novel version, distance and update position formulation has been modified. The selected features are further fused using a novel technique that is based on the serial and standard deviation threshold function. The experimental process of the proposed framework is conducted on three datasets and obtained an accuracy of 98.2%, 99.0%, and 98.7%, respectively. In addition, a detailed Wilcoxon signed‐rank analysis is conducted and shows the proposed method significance performance. Based on the results, it is concluded that the proposed method accuracy is improved after the fusion process. In addition, the comparison with recent techniques shows the proposed method as more significant in terms of accuracy and precision rate.
Sarcopenia knowledge of geriatric rehabilitation patients is low while they are willing to start sarcopenia treatment: EMPOWER‐GR
Authors: Verstraeten Laure M.G. , Mashni Amir , van Wijngaarden Janneke P. , Meskers Carel G.M. , Maier Andrea B. 
Published: December 2023

AbstractBackgroundSarcopenia is prevalent in 20–50% of geriatric rehabilitation inpatients and is associated with functional dependence and mortality. The aim is to assess knowledge of geriatric rehabilitation inpatients on sarcopenia and their willingness and perceived barriers to start treatment.MethodsEnhancing Muscle POWER in Geriatric Rehabilitation (EMPOWER‐GR) is an observational cohort of geriatric rehabilitation inpatients in Amsterdam, the Netherlands. Knowledge of sarcopenia, willingness and perceived barriers to treatment were assessed with a survey among inpatients. Importance of and self‐perceived muscle health were rated using a visual analogue scale from 0 to 10. Descriptive statistics were used.ResultsInpatients' (n = 157, 59.9% female) mean age was 80.5 years (SD 7.3). Sarcopenia (European Working Group on Sarcopenia in Older People 2) prevalence was 21.7%. Five inpatients (3.2%) had heard of sarcopenia and had knowledge of its definition. Median muscle health was rated as 6 (interquartile range: 4–7). After explanation of treatment options, 67.1% were willing to start resistance exercise training (RET), 61.1% a high‐protein diet and 55.7% oral nutritional supplements (ONS). Inpatients with sarcopenia were less willing (51.6%) to start a high‐protein diet compared with inpatients without sarcopenia (77.8%) (P = 0.002); there was no difference for RET and ONS. Most reported barriers to treatment were ONS dislike (17.0%), too many other health issues (13.6%), doubts about treatment effectiveness/importance (12.9%) and RET intensity/difficulty (10.2%).ConclusionsKnowledge of sarcopenia was low, while the majority of inpatients showed willingness to start treatment. A dislike of ONS, RET difficulty and too many other health issues may reduce willingness to start treatment. Education is important to increase sarcopenia‐related health issues in geriatric rehabilitation inpatients.
The application value of lung ultrasound scoring in assessing disease severity: Evaluation of small‐scale outbreaks of COVID‐19
Authors: Han Lina , Ke Helin , Xiao Yang , Xu Shaodan , Huang Zhibin , Wang Han , Lyu Guorong , Li Shilin 
Published: December 2023

AbstractPurposeThis study explored the use of transthoracic lung ultrasound for evaluating COVID‐19 patients, compared it with computed tomography (CT), and examined its effectiveness using 8 and 12 lung regions.MethodsA total of 100 patients with COVID‐19 and 40 healthy volunteers were assessed using 12 regions (bilateral upper/lower regions of the anterior/lateral/posterior chest) and simplified 8 zones (bilateral upper/lower regions of the anterior/lateral chest) transthoracic lung ultrasound. The relationships between ultrasound, CT, and clinical indicators were analyzed to evaluate the diagnostic value of ultrasound scores in COVID‐19.ResultsIncreased disease severity correlated with increased 8‐ and 12‐zone ultrasound and CT scores (all p < 0.05). The modified 8‐zone method strongly correlated with the 12‐zone method (Pearson's r = 0.908, p < 0.05). The 8‐ and 12‐zone methods correlated with CT scoring (correlation = 0.568 and 0.635, respectively; p < 0.05). The intragroup correlation coefficients of the 8‐zone, 12‐zone, and CT scoring methods were highly consistent (intragroup correlation coefficient = 0.718, p < 0.01). The 8‐zone ultrasound score correlated negatively with oxygen saturation (rs = 0.306, p < 0.05) and Ca (rs = 0.224, p < 0.05) and positively with IL‐6 (rs = 0.0.335, p < 0.05), erythrocyte sedimentation rate (rs = 0.327, p < 0.05), alanine aminotransferase (rs = 0.230, p < 0.05), and aspartate aminotransferase (rs = 0.251, p < 0.05). The 12‐zone scoring method correlated negatively with oxygen saturation (rs = 0.338, p < 0.05) and Ca (rs = 0.245, p < 0.05) and positively with IL‐6 (rs = 0.354, p < 0.05) and erythrocyte sedimentation rate (rs = 0.495, p < 0.05).ConclusionLung ultrasound scores represent the clinical severity and have high clinical value for diagnosing COVID‐19 pneumonia. The 8‐zone scoring method can improve examination efficiency and reduce secondary injuries caused by patient movement.
Malignant triton tumor of uterus: A case report and literature review
Authors: Jiang Ti‐Ling , Liu Yan , Ji Bo , Sheng Dong‐Hua , He Qi‐Can , Song Jia‐Chun , Wang Gong , Wang Kai 
Published: December 2023

AbstractMalignant triton tumor (MTT) is a highly aggressive malignant neoplasm, classified as a variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. There are few reports that MTT occurred in urogenital system. In the present study, we report the first MTT occurring in the uterus. A 57‐year‐old woman came to the emergency department due to persistent vaginal bleeding for 2 months. The gynecological palpation found that a club‐shaped excrescence existed in the vagina about 7 cm × 3 cm × 3 cm. The mass located in the lower segment of the uterus and the cervix was confirmed by gynecological vaginal ultrasound and magnetic resonance imaging, which was preliminarily diagnosed as cervical carcinoma. After neoplasm punch biopsy, the pathological diagnosis was malignant triton tumor. The patient finally lost follow‐up. This is the first report about MTT in the uterus and suggests that pathological biopsy combined with imaging examination is necessary for the diagnosis of rarely MTT.