bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Use of a Simulation in Pediatric Type 1 Diabetes Sick-Day Education for Patients and Caregivers
Authors: Delsart Hailee L. , Corathers Sarah D. , Fox Catherine , Geis Gary L. , Brady Patrick W. , Smith Emily D. , Kirkendall Eric S. , Walsh Kathleen E. 
Published: February 2025

OBJECTIVE
Management of type 1 diabetes during illness confers risk for serious harm because sick days happen infrequently, management is complex and multistep, and errors can result in diabetic ketoacidosis and hospitalization. Simulation offers a safe, experiential learning environment in which to practice skills with the goal of identifying and closing knowledge gaps. We hypothesized that simulation of sick-day scenarios with patients and caregivers via video conference could be used to assess knowledge of sick-day management for type 1 diabetes and determine the availability of necessary supplies at home.

RESEARCH DESIGN AND METHODS
Our study included development of performance-based, scripted sick-day scenarios; selection and training of content experts as simulation facilitators; piloting and iterative revision of scenarios; and implementation of simulation sessions. Five distinct scenarios were created for either insulin injections or continuous insulin pump therapy. Each participant was block randomized to receive three of the five scenarios. Participant performance was measured by categorizing actions as most desired, less desired, or incorrect.

RESULTS
Ten caregivers and two young adults with type 1 diabetes participated in 12 simulations, representing 14 individuals with type 1 diabetes. The most common category of less desired and incorrect processes chosen by participants was ketone management.

CONCLUSION
Simulation-based training for sick-day management is a feasible, interactive form of education for people with type 1 diabetes and caregivers. Video conferences allowed firsthand observation of supplies and resources available to families at home. Participant understanding of sick-day management will inform future interventions to address challenges with ketone management and recognition of diabetes technology issues when caring for an ill child with type 1 diabetes.
Postanesthetic neurologic signs progressing to seizures in 2 dogs and 1 cat with unoperated congenital portosystemic shunts after non–shunt-related surgery
Authors: Mullins Ronan A. , O’Sullivan Joseph , Simpson Matthew , Lipscomb Victoria J. 
Published: February 2025

Abstract

OBJECTIVE
To describe the development of neurologic signs progressing to seizures in 2 dogs and 1 cat with unoperated single congenital portosystemic shunts (CPSSs) after general anesthesia for non–shunt-related surgery and no intraoperative shunt manipulation.

ANIMALS
2 dogs (dog 1 [a 5-year-old 7.1-kg castrated male Bichon Frise] and dog 2 [a 10-year-old 7.3-kg castrated male Bichon Frise]) and 1 cat (cat 1 [a 2-year-old 3.8-kg castrated male Ragdoll]).

CLINICAL PRESENTATION
Medical records from the University College Dublin Veterinary Hospital and Royal Veterinary College Queen Mother Animal Hospital were searched for dogs and cats with unoperated CPSSs that developed neurologic signs progressing to seizures after general anesthesia for non–shunt-related surgery between January 1, 2015, and June 31, 2024.

RESULTS
3 animals were identified. Dogs 1 and 2 both underwent cholecystectomy, whereas cat 1 underwent jejunal enterectomy. None had known preoperative seizures, although both dogs had experienced prolonged anesthetic recovery after previous surgery and the cat had a 3-day history of ataxia, walking into walls, and generalized weakness. All 3 animals developed severe neurologic signs including seizures within 48 hours postoperatively. Both dogs were euthanized before hospital discharge: dog 1 for suspected aspiration pneumonia coupled with severe neurologic signs and dog 2 for refractory neurologic signs. Cat 1 survived to hospital discharge and underwent 2 subsequent CPSS attenuation surgeries.

CLINICAL RELEVANCE
Postanesthetic neurologic signs can occur in animals with CPSSs without intraoperative shunt manipulation. This possible complication should be discussed with owners of animals with unoperated CPSSs that require general anesthesia for non–shunt-related surgery.
Novel Metaheuristic Algorithms and Their Applications to Efficient Detection of Diabetic Retinopathy
Authors: Hassaballah Mahmoud , Hameed Mohamed Abdel 
Published: February 2025

Abstract
It is an extremely important to have an AI-based system that can assist specialties to correctly identify and diagnosis diabetic retinopathy (DR). In this study, we introduce an accurate approach for DR diagnosis using machine learning (ML) techniques and a modified golf optimization algorithm (mGOA). The mGOA optimizes ML classifiers through finding the best available parameters with respect to objective functions, hence decreases the number of features and increases the classifier’s accuracy. A fitness function is employed to minimize the feature number of the medical dataset. The obtained results showed superiority of the mGOA with higher convergence speeds without extra processing costs across the datasets compared with several competitors. Also, the mGOA attained maximum accuracy and optimally reduced the number of features in the binary and multi-class datasets achieving the best CEC’2022 benchmark results compared with other metaheuristic algorithms. Based on this findings, three optimized ML classifiers called mGOA-SVM, mGOA-radial SVM,and mGOA-kNN were introduced as tools for classification of diabetic retinopathy disease and their performance was assessed on Messidor and EyePACS1 datasets. Experimental results demonstrated that mGOA-SVM and mGOA-radial SVM achieved remarkable accuracy in classification of DR disease with an average accuracy of 98.5% and precision of 97.4%.
A eficiência de novas tecnologias na terapêuticas calcificação valvar
Authors: Alencar Lucas Rezende de , Viana Cassiano Ossipe dos Santos , Cronemberger Lucas Rocha , Oliveira João Pedro Nascimento Lagos , Ferreira Lucas Luz , Barbosa João de Sousa Pinheiro 
Published: February 2025

Objetivo: Investigar como os avanços na compreensão dos mecanismos moleculares da calcificação valvar podem impactar o desenvolvimento e a eficácia das novas terapias emergentes para o tratamento dessa condição, comparando com os métodos tradicionais. Métodos: Esta revisão integrativa da literatura. PubMed e Biblioteca Virtual em Saúde (BVS), focando em artigos publicados nos últimos cinco anos, entre 2019 e 2024. O objetivo da revisão foi identificar estudos que abordassem os mecanismos moleculares da Calcificação da Válvula Aórtica (CAVD) e potenciais intervenções terapêuticas. A busca foi realizada utilizando descritores Decs/MeSH relevantes, incluindo "calcification," "RNA," "valve calcification," e "aortic valve calcification." Inicialmente, 422 estudos foram identificados antes da triagem. Resultados: A análise revelou avanços significativos com biomarcadores, como o cfDNA, IL-38 e microRNAs, e terapias experimentais com vitamina K2, curcumina e H₂S, que mostraram potencial em inibir a progressão da calcificação valvar. Considerações finais: As novas terapias moleculares apresentam resultados promissores para o tratamento da calcificação valvar. Contudo, estudos futuros devem incluir amostras maiores e mais diversificadas para validar sua eficácia em diferentes populações e, assim, ampliar a aplicabilidade clínica dessas tecnologias.
Genotype-phenotype spectrum and correlations in Chinese patients with keratinocytic epidermal naevus: A retrospective study of 22 cases
Authors: Li Zhongtao , Wang Sheng 
Published: February 2025

Background
Keratinocytic epidermal naevus is characterised by hyperkeratotic lesions arranged along Blaschko’s lines. So far, multiple genes have been implicated, but there is no detailed data or genotype-phenotype correlation studies of keratinocytic epidermal naevi in Chinese patients.

Objective
To evaluate the clinical, histopathological and genetic features, genotype-phenotype correlations of keratinocytic epidermal naevus in the Chinese population.

Methods
A retrospective study of patients with keratinocytic epidermal naevi referred to the Department of Dermatology, West China Hospital, in the last four years. Medical history, clinical data, histopathological characteristics, and evidence of genetic mutations were collected from 22 unrelated Chinese patients with this problem.

Results
The distribution of the keratinocytic epidermal naevi exhibited right-side dominance. Non-epidermolytic epidermis naevus was much more common. Eight reported missense mutations were found in this study, which were detected in five genes, including HRAS, KRT10, FGFR3, GJB2, and PIK3CA. HRAS was the most commonly affected gene (9/22, 40.91%) in this study, with the c.37G>C (6/22, 27.27%) substitution representing a possible hotspot mutation. Mutation allele loads were higher in the affected lesions than blood samples. Epidermolytic epidermal naevus was found in three patients exclusively carrying KRT10 mutations. Inflammatory epidermal naevi were caused by mutations of KRT10 and PIK3CA. Most of the mosaic mutations detected in keratinocytic epidermal naevi patients were the same as germline mutations identified in systemic diseases caused by these genes.

Limitations
The retrospective nature of the study.

Conclusion
Our findings reveal the genotype-phenotype spectrum and their correlation amongst Chinese patients with keratinocytic epidermal naevi. In addition, our data underscores the importance of genetic testing in lesional skin to help characterise and categorise keratinocytic epidermal naevi, decide on a therapeutic strategy, and offer genetic counselling and prenatal diagnosis.
Utility of immunohistochemistry for immunoglobulin G4 in the diagnosis of pemphigus
Authors: Begum Shameera , Krishnamurthy Bhavani , Srinivasan Sowmya 
Published: February 2025

Objectives:
Direct immunofluorescence (DIF) is the diagnostic gold standard for pemphigus. However, it is limited by the requirement of additional fresh-frozen tissue, immediate processing, and availability of a fluorescent microscope. The present study aims to assess the role of immunoglobulin G4 (IgG4) immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue for the diagnosis of pemphigus by comparing IgG4-IHC results to DIF.

Materials and Methods:
IgG4-IHC was performed on formalin-fixed paraffin-embedded sections of lesional and perilesional skin biopsies of 30 cases of DIF-proven pemphigus and 30 non-pemphigus controls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were analyzed for IgG4-IHC on lesional and perilesional biopsies to compare their diagnostic significance.

Statistical analysis:
Data were analyzed using the Statistical Package for the Social Sciences version 29. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy of IgG4-IHC were calculated using standard formulae. Receiver operator curve analysis was performed for IgG4-IHC in lesional and perilesional skin to compare their diagnostic significance. The youden index was calculated using the formula “sensitivity + specificity – 1.” P < 0.05 was considered statistically significant.

Results:
Out of 30 cases enrolled for the study, 26 (86.6%) were diagnosed as pemphigus vulgaris and four (13.4%) as pemphigus foliaceous. The sensitivity, specificity, PPV, NPV, and diagnostic accuracy of IgG4-IHC for pemphigus on lesional biopsy were 66.7%, 100%, 100%, 75%, and 83.3% while the sensitivity, specificity, PPV, NPV, and diagnostic accuracy for the perilesional biopsy were 56.7%, 100%, 69.8%, and 78.3%, respectively.

Conclusions:
Our study indicated that IgG4-IHC is highly specific, but not sufficiently sensitive to replace DIF to diagnose pemphigus. IgG4-IHC on lesional skin is likely to be particularly valuable in a setting where a frozen section or immunofluorescence facility is not available. Further studies on larger samples are warranted to validate the role of IgG4-IHC in pemphigus.
РАЗРАБОТКА ДВУХСТУПЕНЧАТОГО ПРОЦЕССА АНАЭРОБНОЙ ПЕРЕРАБОТКИ СПИРТОВОЙ БАРДЫ НА ДЕЙСТВУЮЩИХ ОЧИСТНЫХ СООРУЖЕНИЯХ СПИРТОВОГО ПРОИЗВОДСТВА
Authors: ГЛАДЧЕНКО М А. , КАНУННИКОВА М А. , ГАЙДАМАКА С Н. , КОРНИЛОВА А А. 
Published: February 2025

Сформулирован и реализован на практике подход, обеспечивающий корректировку проектного инженерного решения и вывод производственного процесса переработки отходов спиртового производства на целевые значения показателей ХПК (химического потребления кислорода), эффективности очистки и низкого выхода объемов сточных вод. Достигнуть целевого результата удалось путем замены исходно предложенного по коммерческому проекту анаэробного мезофильного (35 °С) реактора на двухступенчатый процесс анаэробного сбраживания спиртовой барды, включавший биореакторы периодического действия (SBR), функционирующие по принципу контакт процесса, перед подачей на вторую стадию - аэробной конверсии, включающей процессы нитриденитрификации. При разработке двухступенчатой системы анаэробной деградации барды в эксплуатацию было введено последовательно два SBR реактора с разными температурными режимами (на 1-ой ступени - термофильный 65 °С и на 2-ой ступени - мезофильный 35 °С)...
An approach has been formulated and put into practice to ensure that the design engineering solution is adjusted and the production process for processing waste from alcohol production is brought to the target values of COD (chemical oxygen demand), treatment efficiency and low yield of wastewater volumes. It was possible to achieve the target result by replacing the anaerobic mesophilic (35 °C) reactor initially proposed in the commercial project with a two-stage process of anaerobic digestion of distillery vinasse, which included batch bioreactors (SBR), operating on the contact process principle, before feeding it to the second stage - aerobic conversion, including nitri-denitrification processes. When developing a two-stage system for anaerobic degradation of vinasse, two SBR reactors with different temperature conditions were put into operation sequentially (at the 1st stage - thermophilic 65 °C and at the 2nd stage - mesophilic 35 °C). The proposed engineering solution made it possible to completely eliminate the consumption of artesian water for diluting the original distillery vinasse and, at the same time, in just 7 days (residence time at the 1st stage - 2 days, at the 2nd stage - 5 days) to achieve the efficiency of reducing the COD of the processed distillery vinasse at the level of 75-85 %...
ОПРЕДЕЛЕНИЕ ПРЕДЕЛЬНО ДОСТИЖИМОЙ АБЕРРАЦИОННОЙ КОРРЕКЦИИ ОПТИЧЕСКИХ СИСТЕМ РАЗЛИЧНОЙ СЛОЖНОСТИ
Authors: БЕЗДИДЬКО С Н. 
Published: February 2025

На начальных этапах проектирования новых оптических систем необходимо спроектировать исходную оптическую систему, исходя из требований технического задания. При этом в большинстве случаев в качестве исходных оптических систем используют ранее разработанные оптические системы, полученные с помощью поиска прототипа из архива готовых оптических систем. При этом важнейшей задачей является задача изучения коррекционных возможностей различных типов оптических систем и выбора наиболее приемлемых вариантов систем для дальнейшего проектирования. В этом отношении одной из важнейших практических задач является задача выбора исходных оптических систем, наиболее целесообразных для применения при заданных в ТЗ значениях светосилы и углового поля зрения, а также оценка предельных значений светосилы и углового поля зрения для каждой рассматриваемых оптических схем. Указанные задачи не получили достаточного освещения в литературе и именно использование ортогональных аберраций и новых подходов по анализу аберрационных свойств оптических систем позволяют успешно решать подобные задачи.
At the initial stages of designing new optical systems, it is necessary to design the starting optical system based on the requirements of the technical specifications. In most cases, lens designer only can choose the starting optical system from previously developed systems or from patent information. In this case, the most important task is to study the correction capabilities of various types of optical systems and select the most suitable system options for further design. In this regard, one of the most important practical tasks is the task of selecting the starting optical systems that are most appropriate for use at the values of aperture ratio and angular field of view specified in the technical specifications, as well as assessing the limiting values of aperture ratio and angular field of view for each optical scheme under consideration. These problems have not received sufficient coverage in the literature, and it is the use of orthogonal aberrations and new approaches to analyzing the aberration properties of optical systems that make it possible to successfully solve such problems.
Мониторинг состояния коммуникационных сетей на основе облачных вычислений в режиме реального времени
Authors: Амоа К.А.Ж. , Сидоренко Е.В. , Рындин Н.А. 
Published: February 2025

При создании коммуникационной сети неизбежно возникают различные помехи, негативно сказывающиеся на ее эффективности. Отсутствие мер по устранению таких помех затрудняет оптимизацию сети. Среди проблем, вызванных помехами, проблема их блокировки является одной из наиболее существенных. Эта неразрешенная проблема может сделать невозможным успешное проектирование сети. Для решения проблем, связанных с тем, что традиционный метод имеет длительное время отклика на мониторинг перегрузки сети связи, а эффект обнаружения не идеален, предлагается метод мониторинга в реальном времени, основанный на облачных вычислениях для блокировки сети связи. Во-первых, устанавливается точка мониторинга сети связи, и приемник завершает процесс сбора коммуникационных данных. На основе собранных данных выполняется постоянный расчет трафика для определения наличия аварийного состояния блокировки в канале сети связи и определения точного местоположения точки блокировки. Таким образом, информация генерирует тревожное сообщение для получения результатов мониторинга. Экспериментально проанализированы время работы в режиме реального времени и точность метода мониторинга. Установлено, что метод мониторинга позволяет контролировать время задержки в пределах 0,2 с, а частота ошибок мониторинга является низкой.
When creating a communication network, various obstacles inevitably arise that negatively affect its effectiveness. The lack of measures to eliminate such interference makes it difficult to optimize the network. Among the problems caused by interference, the problem of blocking them is one of the most significant. This unresolved issue may make successful network design impossible. In order to solve the problems that the traditional method has a long response time to monitor the congestion of the communication network and the detection effect is not ideal, a real-time monitoring method based on cloud computing for blocking the communication network is proposed. Firstly, a communication network monitoring point is established, and the receiver completes the communication data collection process. Based on the collected data, continuous traffic calculation is performed to determine whether there is an emergency blocking state in the communication network channel and determine the exact location of the blocking point. In this way, the information generates an alarm message to obtain the monitoring results. The real-time running time and the accuracy of the monitoring method are experimentally analyzed. It is found that the monitoring method can control the delay time within 0.2 s, and the monitoring error rate is low.
A Critical Eco-perspective in English Textbook for Indonesian 12th Graders: A Case on Nationally Issued Textbook
Authors: Seli Fenny Yutika , Manar Marsandi , Hardono Adinda Apriliani , 'Aini Syarifah 
Published: February 2025

Ecological values in textbooks are essential because they help instill environmental awareness and responsibility in students from an early age to support sustainable development. The study addresses how ecological values are portrayed in Indonesian 12th-grade English textbooks. Using a qualitative content analysis framework, this study examines the transitivity system found in the textbook. The analysis emphasizes environmental conservation, sustainable practices, and encouraging cognitive engagement through positively framed language and relatable, contextual examples. Through a thorough exploration of how elements are connected, positive language use, and specific contextual details, the research provides nuanced insights into the representation of ecological values. This research provides valuable insights into the nuanced instructional approach that shapes environmental awareness within the context of these textbooks. These findings suggest that English Language Teaching (ELT) materials for Indonesian students should actively incorporate eco-friendly linguistic elements and emphasize sustainability-oriented pedagogy to cultivate environmental responsibility.
Effect of use of Different Levels of Zingiber officinale on Production ‎‎,blood traits and Liver enzymes in Awassi Ewe’s Blood‎
Authors: A.Al-Khayat ‎ Dhia , M.M. Zakri Ahmed 
Published: February 2025

This research was designed to study the effect of tow levels of Zingiber officinale on Body weight , Hb , PCV ,WBCs account , Lymphocytes , Neutrophiles accounts GOT and ALP liver enzymes in Awassi ewe’s blood , Nine Awassi ewes aged 1.5 years were divided into 3 equal groups as followed : Group A was treated by 10 gm Zingiber officinale / animal /daily (2.5%) of diet While group B were treated with 20 gm Zingiber officinale / animal daily (5%) of diet and group C considered as Control group without given Zingiber officinale with diet ,the results showed that significant increase (P<0.05)on body weight in treatment B during weeks of trail compare with the groups A & C .
also in blood traits there was a significant increase (P<0.05) in PCV, Hb, WBCs ,Lymphocytes accounts in group B during weeks of trail compare with the groups A & C while there was significant decrease (P<0.05) in Neutrophile accounts in group B during weeks of trail compare with the treatments A &C, there was significant decrease (P<0.05)on GOT (Glutamic Oxaloacetic Transminase) level in group B compare with the groups A & C. While there was a significant increase (P<0.05) on ALP (Alkaline Phosphatase) in group B compare with the groups A&C.
We conclude that 20 gm / animal (5%) of diet increase body weight ,blood traits & Liver enzyme ALP in compared with other groups
Pelatihan Pembuatan Media Pembelajaran Berbasis Technological Pedagogical Content Knowledge (TPACK) Di SDN 008 Samarinda Ulu
Authors: Linda Apnita , Yati Asmita , Atikah Atikah , Samosir Dinawaty , Yuliana Dina , Rahayu Erika Dea Fitri , Telnoni Junefra , Bemi Lidia , Nabila Ridha , Reski Wahyuni , Azainil Azainil 
Published: February 2025

Pelatihan pembuatan media pembelajaran berbasis Technological Pedagogical Content Knowledge (TPACK) ini bertujuan untuk memberikan manfaat bagi guru SDN 008 Samarinda Ulu dalam meningkatkan kualitas pembelajaran, memperkaya pengalaman belajar peserta didik, meningkatkan keterlibatan siswa dan mendukung pembelajaran berbasis teknologi, serta memfailitasi pembelajaran diferensial. Metode yang digunakan dalam kegiatan pelatihan ini adalah pendekatan kolaboratif antara mahasiswa Pendidikan Profesi Guru (PPG) Prajabatan Universitas Mulawarman dan guru SDN 008 Samarinda Ulu, yang dalam hal ini mahasiswa PPG Universitas mulawarman memberikan pelatihan pembuatan media pembelajaran berbasis TPACK. Kegiatan ini dilaksanakan di SDN 008 Samarinda Ulu, dengan peserta berjumlah 15 orang. Evaluasi kegiatan dilakukan untuk menilai keberhasilan, implementasi dan memberikan umpan balik untuk perbaikan lebih lanjut. Evaluasi ini dilakukan dengan memberikan kuisioner secara tertutup dengan 8 pertanyaan. Dari hasil kuisioner diperoleh sebanyak 87% peserta sudah mampu membuat media pembelajaran berbasis TPACK dengan aplikasi quizziz dan liverworksheet. ​