bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arsitektur Enterprise untuk Lembaga Swadaya Masyarakat berdasarkan The Open Group Architecture Framework (TOGAF) (Enterprise Architecture for Non-Governmantal Organization based on The Open Group Architecture Framework (TOGAF))
Authors: Herdi Tazkiyah , Dores Ardiansyah 
Published: January 2024

Tata kelola TI pada organisasi kecil menengah pada satu dekade terakhir telah menyoroti beberapa fokus tata kelola TI, salah satunya adalah kecukupan kerangka kerja pada hal-hal yang organisasilakukan. Kerangka kerja seperti The Open Group Architecture Framework (TOGAF), dapat memberikanorganisasi suatu dasar untuk mengelola teknologi informasi. Lembaga Swadaya Masyarakat (LSM) memiliki beberapa program yang dilakukan sehari-hari, yaitu advokasi, promosi dan edukasi hak anak, pemberdayaan dan pendampingan, penguatan organisasi dan pengembangan jaringan organisasi. Pada studi kali ini, kami menemukan permasalahan dalam penerapan rancangan arsitektur bisnis, proses bisnis pada LSM ternyata memiliki proses bisnis yang berkelanjutan. Untuk itu kami melakukan studi mendalam dengan menerapkan BPMN (Business Process Modelling Notation) dan Porter’s Value Chain. Penerapan kedua metode ini berhasil menjabarkan proses bisnis berjalan dan memudahkan dalam penjabaran dan perancangan pada tahapan-tahapan TOGAF selanjutnya. Sehingga, pemanfaatan teknologi informasi dapat dipetakan dan bermanfaat dari sisi strategis dan operasional LSM.
PARIWISATA DIGITAL: TRANSFORMASI PEMASARAN PARIWISATA INDONESIA MELALUI INSTAGRAM DAN YOUTUBE PEMERINTAH SELAMA MASA PANDEMI COVID-19
Authors: Herlina Alfarida 
Published: January 2024

Artikel ini membahas tentang dampak pembatasan sosial selama pandemi COVID-19 pada sektor pariwisata serta peran pemerintah dalam upaya pemulihan dampak yang terjadi melalui beberapa program terkhusus pemasaran sosial pada media sosial (owned media). Pemanfaatan media sosial menjadi pilihan tepat dan solusi yang diandalkan sebagai upaya transformasi pemasaran pariwisata berkelanjutan. Program ini tidak akan berjalan dengan efektif tanpa adanya strategi pemasaran yang baik. Pemilihan serta penggunaan konten promosi mempengaruhi pesan yang ingin disampaikan. Oleh karena itu, artikel ini berupaya menganalisis isi dari konten media sosial (Instagram dan Youtube) milik Kemenparekraf Republik Indonesia dan menganalisis efektifitas konten promosi tersebut..
Study on the Development of Fiber-Rich Noodles through the Substitution of Wheat Flour with Pregelatinized Tannia Flour
Authors: Putra I Nengah Kencana , Suparthana I Putu , Istri Sri Wiadnyani Anak Agung 
Published: January 2024

Traditional noodles are often criticized for their low fiber content, a component with numerous health benefits in preventing degenerative diseases. Tannia, a potential food source in Indonesia, is recognized for its richness in fiber. This study evaluated the chemical properties, cooking quality, and sensory aspects of noodles made from a composite of wheat flour and pregelatinized tannia flour (PTF). PTF, obtained by boiling tannia tuber slices at a temperature of 95°C for 10 minutes, drying, mashing, and sieving using a 60-mesh sieve, was used to substitute some of the wheat flour in dry noodles production. Substitution levels ranged from 0% (control) to 30%. Results showed a significant impact on protein, carbohydrate, and crude fiber content, as well as color, cooking quality, and sensory properties. Crude fiber increased with substitution, but above 25%, noodles exhibited lower elasticity compared to the control. In conclusion, a 25% substitution of wheat flour with PTF produced noodles with higher crude fiber content, better cooking quality, and sensory properties comparable to control noodles (without substitution). Noodles with 25% substitution had a crude fiber content of 4.89%, while control noodles were at 3.84%
Tripolar Dislocation: Elbow Terrible Triad–Essex-Lopresti Injury–Trans-scaphoid Perilunate Dislocation
Authors: Dukan Ruben , Charles Seyrol , Marc Juvenspan , Emmanuel Masmejean , Salma Otayek , Marc Soubeyrand 
Published: January 2024

Case:
A 23-year-old man presented with a right upper limb injury after a 10-m fall. Initial evaluation demonstrated a terrible triad elbow injury associated with a trans-scaphoid perilunate dislocation. Elbow stabilization with radial head replacement and carpal fixation was performed. Radiographs on postoperative day 7 demonstrated an ipsilateral Essex-Lopresti injury, which had been initially missed, and revision surgery was performed to reconstruct the interosseous membrane.

Conclusion:
Surgeons should maintain a high degree of suspicion for an ipsilateral Essex-Lopresti injury in patients with a terrible triad elbow fracture-dislocation in combination with a trans-scaphoid perilunate dislocation. Both preoperative imaging, including the contralateral side, and intraoperative evaluation are recommended to rule out longitudinal instability of the forearm in the setting of combined wrist and elbow fracture-dislocations.
Corrosion of a Fassier-Duval Telescopic Nail Causing Pain and Osteolysis
Authors: Ngo David , Todd Maya , Accadbled Franck , Foster Bruce , Jellesen Morten Stendahl , Rölfing Jan Duedal , Rawat Jaideep 
Published: January 2024

Case:
A 15-year-old girl known with osteogenesis imperfecta presented with left femoral pain. She had been treated with multiple Fassier-Duval intramedullary nails, which were still in situ. Radiographic imaging demonstrated focal osteolysis and periosteal reaction at the telescopic junction of the rod in the distal femur. She underwent implant removal. Intraoperative sampling demonstrating acute sterile inflammation and presence of brownish colored particles consistent with metal debris and osteolysis. Explant analysis confirmed corrosion of the stainless-steel telescopic nail as the underlying cause.

Conclusion:
Osteolysis and periosteal reaction because of corrosion should be considered in conjunction with other more common causes of pain, such as fracture or infection, in patients treated with telescopic intramedullary nails.
A Data-Driven Methodology to Comprehensively Assess Bone Drilling Using Radar Plots
Authors: Nigam Aman , Kellam James F. , Ambrose Catherine G. , Tai Bruce L. 
Published: January 2024

Background:
The study aims to develop a data-driven methodology to assess bone drilling in preparation for future clinical trials in residency training. The existing assessment methods are either subjective or do not consider the interdependence among individual skill factors, such as time and accuracy. This study uses quantitative data and radar plots to visualize the balance of the selected skill factors.

Methods:
In the experiment, straight vertical drilling was assessed across 3 skill levels: expert surgeons (N = 10), intermediate residents (postgraduate year-2-5, N = 5), and novice residents (postgraduate year-1, N = 10). Motion and force were measured for each drilling trial, and data from multiple trials were then converted into 5 performance indicators, including overshoot, drilling time, overshoot consistency, time consistency, and force fluctuation. Each indicator was then scored between 0 and 10, with 10 being the best, and plotted into a radar plot.

Results:
Statistical difference (p < 0.05) was confirmed among 3 skill levels in force, time, and overshoot data. The radar plots revealed that the novice group exhibited the most distorted pentagons compared with the well-formed pentagons observed in the case of expert participants. The intermediate group showed slight distortion that was between the expert and novice groups.

Conclusion/Clinical Relevance:
This research shows the utility of radar plots in drilling assessment in a comprehensive manner and lays the groundwork for a data-driven training scheme to prepare novice residents for clinical practice.
Treatment and Outcomes of 4,973 Unicameral Bone Cysts
Authors: Ruiz-Arellanos Kim , Larios Felipe , Inchaustegui Maria L. , Gonzalez Marcos R. , Pretell-Mazzini Juan 
Published: January 2024

» Unicameral bone cysts (UBCs) can increase the risk of pathologic fractures of both long and short bones. Although multiple treatments exist, data are conflicting regarding optimal management.» We sought to analyze treatment strategies for UBCs and their rates of successful treatment.» Success rates were analyzed according to treatment modality, with emphasis on filling techniques and/or decompression associated with curettage, and injection compounds.» Curettage with bone substitute and cyst decompression was identified as a highly successful technique for UBC treatment.» Decompressing the cyst wall after injection, regardless of the specific compound used, had a greater potential to enhance healing rates.» The management decision should be individually guided within the patient's context.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
Phase Equilibria Evidence for Intermediate P/T Metamorphism in the Nashoba Terrane and Implications for Acadian Tectonics in Ganderia
Authors: Yao Jannitta T. , Castro Adrian E. , Roberts Nicolas M. , Wolfe Oliver M. , Brunet Isabella M. , Vasey Dylan A. 
Published: January 2024

Abstract
The bedrock exposed in the Nashoba terrane of east-central Massachusetts records a complex history of deformation and metamorphism associated with the collision of Avalonia with the Laurentian margin during the Devonian Acadian orogeny. Although the structural history of the terrane has been well studied, its pressure-temperature (P–T) history is less well constrained, and the mechanisms by which the upper amphibolite facies Nashoba terrane was juxtaposed between greenschist facies rocks to the southeast and northwest have not been established. Here, we apply phase equilibria modeling, geothermobarometry, and petrographic analysis to three garnet-bearing migmatitic rocks from the Nashoba terrane to determine their P–T histories and provide key metamorphic constraints relevant to Acadian orogenic processes. All three samples are from the Nashoba Formation, a unit within the Nashoba terrane consisting of volcaniclastic rocks likely deposited in an arc/back-arc setting near the trailing edge of the Ganderia terrane. Peak subsolidus conditions are determined via the integration of petrographic analysis and thermodynamic modeling. Peak anatectic conditions are constrained with garnet-biotite thermometry + GASP barometry, garnet intersecting rim isopleths, and thermodynamic modeling.
Phase equilibria constraints suggest peak subsolidus conditions ranging from ~550°C to 700°C and ~6–12 kbar. Geothermobarometry, phase equilibria modeling, and garnet rim isopleths constrain biotite-out anatexis to ~700°C–715°C and ~5–8.5 kbar, up to ~2–4 kbar deeper than previously suggested. This synthesis of phase equilibria modeling and petrographic analysis suggests that all three samples record a clockwise P–T path with peak pressures achieved before anatexis associated with the Acadian orogeny at ~394 Ma. These results are inconsistent with a previously interpreted pre-Acadian period of low P/T metamorphism (&lt;5 kbar peak pressures). Instead, this implies a previously unrecognized phase of intermediate P/T crustal thickening preceding anatexis, which we interpret as a result of Acadian orogenesis. We suggest that the Nashoba terrane exposes mid-crustal levels of the Acadian hinterland.
Complement-fixation by antibodies to Plasmodium falciparum
Authors: Chishimba Sandra , Reiling Linda , Boyle Michelle , Kurtovic Liriye , Beeson James 
Published: January 2024

Abstract
In malaria, the fixation and activation of serum complement proteins by antibodies can support immunity by mediating parasite lysis, inhibiting host cell motility and invasion and promoting phagocytosis. Antibodies, bound to malaria antigens, may bind to C1q via their Fc region, initiating the classical complement cascade; C1q is the first step in the classical activation pathway. This protocol measures C1q-fixation by antibodies that target whole Plasmodium falciparum parasites, which can include merozoites, sporozoites, or gametocytes/gametes. The procedure is similar to an ELISA and has the advantage of having high reproducibility, good quantification, and is amenable to high throughput.
A Practical Approach for Targeting Structural Variants Genome-wide in Plasma Cell-free DNA
Authors: Tanaka Hisashi , Murata Michael , Igari Fumie , Urbanowicz Ryan , Mouakkad Lila , Kim Sungjin , Chen Zijing , Vizio Dolores Di , Posadas Edwin , Giuliano Armando 
Published: January 2024

Abstract
Interrogating plasma cell-free DNA (cfDNA) to detect cancer offers promise; however, no current tests scan structural variants (SVs) throughout the genome. Here, we report a simple molecular workflow to enrich a tumorigenic SV (DNA palindromes/fold-back inversions) that often demarcates genomic amplification and its feasibility for cancer detection by combining low-throughput next-generation sequencing with automated machine learning (Genome-wide Analysis of Palindrome Formation, GAPF-seq). Tumor DNA signal manifested as skewed chromosomal distributions of high-coverage 1-kb bins (HCBs), differentiating 39 matched breast tumor DNA from normal DNA with an average AUC of 0.9819. In a proof-of-concept liquid biopsy study, cfDNA from 0.5 mL plasma from prostate cancer patients was sufficient for binary classification against matched buffy coat DNA with an average AUC of 0.965. HCBs on the X chromosome emerged as a determinant feature and were associated with AR amplification. GAPF-seq could generate unique cancer-specific SV profiles in an agnostic liquid biopsy setting.
The Impact of Premature Birth on Multisensory Processes in Very Preterm Schoolchildren
Authors: Décaillet Marion , Denervaud Solange , Huguenin-Virchaux Cléo , Besuchet Laureline , Fumeaux Céline Fischer , Murray Micah , Schneider Juliane 
Published: January 2024

Abstract

Interactions between stimuli from different sensory modalities and their integration are central to daily life, contributing to improved perception. Being born prematurely and the subsequent hospitalization can have an impact not only on sensory processes, but also on the manner in which information from different senses is combined – i.e., multisensory processes. Very preterm (VPT) children (< 32 weeks gestational age) present impaired multisensory processes in early childhood persisting at least through the age of five. However, it remains largely unknown whether and how these consequences persist into later childhood. Here, we evaluated the integrity of auditory-visual multisensory processes in VPT schoolchildren. VPT children (N = 28; aged 8–10 years) received a standardized cognitive assessment and performed a simple detection task at their routine follow-up appointment. The simple detection task involved pressing a button as quickly as possible upon presentation of an auditory, visual, or simultaneous audio-visual stimulus. Compared to full-term (FT) children (N = 23; aged 6–11 years), reaction times of VPT children were generally slower and more variable, regardless of sensory modality. Nonetheless, both groups exhibited multisensory facilitation on mean reaction times and inter-quartile ranges. There was no evidence that standardized cognitive or clinical measures correlated with multisensory gains of VPT children. However, while gains in FT children exceeded predictions based on probability summation and thus forcibly invoked integrative processes, this was not the case for VPT children. Our findings provide evidence of atypical multisensory profiles in VPT children persisting into school-age. These results could help in targeting supportive interventions for this vulnerable population.
Integrative Multiomics Network Analysis of Genetic Risk Factors to Infer Biomarkers and Therapeutic Targets for Rheumatoid Arthritis
Authors: Alsaedi Sakhaa , Mineta Katsuhiko , Tamura Naoto , Gao Xin , Gojobori Takashi , Ogasawara Michihiro 
Published: January 2024

Abstract
Purpose: Understanding the interplay between multiomics genetic risk factors in rheumatoid arthritis (RA) is key to developing effective treatments. Although network genetic-medicine approaches have identified key regulatory nodes of RA, there has been limited analysis of the molecular interactions between its risk actors.
Methods: To identify the significant pathways and predict therapeutic targets of RA, we implemented a workflow to enable the computational multiomics network analysis of its associated risk factors using disease mapping and molecular function similarities.
Results: We identified 28 common risk factors and biomarkers between three main biological pathways. Two key proteins are discovered as potential RA drug targets and a causal RA risk factor is associated with Alzheimer’s disease.
Conclusion: This analysis suggests that drugs approved for other diseases mapped with RA could be repurposed for other diseases with the same pathways. This study provides insight into disease pathogenesis and enhances drug discovery for RA and other complex multifactorial diseases.
Loss of ERRγ promotes lineage plasticity towards neuroendocrine prostate cancer
Authors: Giguere Vincent , Li Ting , Dufour Catherine , Han Lingwei 
Published: January 2024

Abstract
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC). The molecular mechanisms underlying the progression of CRPC toward NEPC remain incompletely understood and effective treatments to be discovered. Herein, we report that loss of the nuclear receptor ERRγ expression promotes neuroendocrine differentiation of PTEN-deficient prostate adenocarcinoma. Using human datasets, we first established that expression of ESRRG is downregulated in both treatment-induced and de novo NEPC. In agreement with these findings, Esrrg expression is also decreased in mouse models of the disease while prostate-specific deletion of Esrrg accelerates the development of NEPC characteristics in PTEN-deficient mice. In cellular models of human prostate cancer (PCa), rescuing ERRγ expression reverses high levels of NEPC markers, inhibits NEPC differentiation, and impedes growth of PTEN-deficient PCa cells supported by suppression of oncogenic metabolic reprogramming. Loss of ERRγ also results in the activation of a neuroendocrine transcriptional program marked by the expression of EZH2 and RET kinase whose pharmacological inhibition impedes the growth of ERRγ-deficient prostate cancer tumor organoids. Altogether, our findings reveal that loss of ERRγ drives adeno-to-neuroendocrine lineage plasticity in PCa and offer potential therapeutic strategies to prevent the development of poor outcome NEPC.
Inferring Carbon Emissions from Human Mobility Data
Authors: Lu Xin , Wang Mengning , Zhang Xiaoling , Tan Suoyi , Zhang Qing , Sai Bin , Cai Mengsi , Guo Shuhui , Wrathall David , Obersteiner Michael , Li Mengjun , Liu Zhu , Chen Xiaohong 
Published: January 2024

Abstract

Accurate identification, quantification, and continual monitoring of carbon emissions constitute pivotal elements for proactive climate interventions. Conventional methodologies like direct measurement, including point-source assessments or remote sensing, often face challenges related to high costs or limited accuracy. Especially in low- and middle-income nations experiencing escalating emissions, carbon monitoring heavily relies on the administrative capabilities of local governments, which frequently lack adequate monitoring infrastructures. Addressing this predicament, our study introduces a computational framework to forecast CO2 emissions by leveraging comprehensive observable human activity data from third-party sources. Our findings elucidate a robust correlation between multi-origin CO2 emissions and human mobility (r = 0.89). Notably, machine learning models adeptly predict these emissions by integrating characteristics extracted from temporally aggregated, anonymized mobility networks (R2≈1.0). We demonstrate that the model effectively captures the notable reduction in CO2 emissions during the COVID-19 lockdown, with both human mobility and CO2 emissions in China decreasing by 56.97% and 32.45%, respectively. The prediction accuracy remains high for countries with varying social economic development, such as the U.S., Italy and Mexico. This study presents an inexpensive, real-time, and robust method of quantifying CO2 emissions on a large scale with high precision, and it could facilitate tailored CO2 emission reduction strategies, grounded in robust scientific evidence derived from the dynamics of human mobility.
The role of tailored climate scenario information for the
perceived legitimacy of climate policy paths
Authors: Hulkkonen Mira , Mielonen Tero , Leppänen Saara , Laakso Anton , Kokkola Harri 
Published: January 2024

Abstract

How does personally tailored climate impact information affect the attitudes towards climate policy paths? We developed an interactive online tool to depict the outcomes of downscaled climate models and a personalized vulnerability estimate. A survey (n=1017) representing Finnish public was conducted to find out the level of knowledge, attitudes towards climate policies and psychological distance to climate change among different demographic groups before and after using the tool. Based on the results, tailored information about climate scenarios increases knowledge on climate impacts, but the effect on the perceived legitimacy of climate policy paths depends on demographic group and personal vulnerability. After using the tool, the respondents' confidence in own knowledge increased and the potential of climate policies to alleviate changes in the living environment was perceived as higher. No polarization in attitudes towards climate science and policy was found between respondents with urban and rural domicile. However, age and income level were associated with differences in attitudes and psychological distance to climate impacts. The respondents perceived climate impacts as spatially proximal, while the temporal and social dimensions of distance indicated more variation. For those with low vulnerability level, climate impacts appeared as more distant after obtaining tailored information.