bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative efficacy of different tenderizing agents and time on Physicochemical textural and organoleptic properties of squid (Todarodes pacificus) muscle
Authors: Baykal Mehtap , Çelik Mehmet , Çelik Ladine , Küçükgülmez Aygül 
Published: October 2023

AbstractThis study aimed to investigate the chemical, physical, textural, and sensory properties of the squid (Todarodes pacificus) muscle during different tenderization agents (yeast, milk, and mineral water) and times (3, 6, 12, and 24 h). The results of the analyses showed that different treatments and their durations affected the dry matter, ash, lipid, and crude protein content of the squid. According to sodium dodecyl sulfate–polyacrylamide gel electrophoresis results, it was observed that there was a slight decrease in band intensities based on different treatments and their durations. However, no significant changes were observed in myosin actin and paramyosin bands. It was found that the hardness (359.7 N), cohesiveness (0.63), and gumminess (233.2 N) parameters increased at the 6th hour, decreased at the 12th hour, and increased again at the 24th hour of the treatment. According to the scanning electron microscopy results, the most affected groups by the application and duration were found to be the mineral water group at the 12th and 24th hours, and the milk group at the 24th hour. Fibers in all marinated squid muscles were observed to spring significantly more compared to the positive and negative control groups. The taste score was found to be significantly higher in the group treated with yeast for 3 h and it was evaluated by the panelists as the most delicious squid among all of the groups. As a result of the study, it was determined that the chemical, physical, and sensory properties of squid could be improved by marinating with yeast, milk, and mineral water for different durations.
Microwave‐assisted extraction optimization of sesquiterpene lactones from Inula helenium roots: A sustainable approach to reduce energy consumption and carbon footprint
Authors: Özcan Fahriye Şeyma , Dikmen Hilal , Özcan Nihat , Çetin Özlem , Çelik Mustafa , Trendafilova Antoaneta 
Published: October 2023

AbstractInula helenium roots are consumed as natural flavor components and raw or cooked as food, and their extracts are rich in sesquiterpene lactones such as alantolactone (AL) and isoalantolactone (IAL), which have recently attracted great attention due to their pharmacological properties. The industrial utilization of these compounds requires the development of green, efficient, cost‐effective, and sustainable extraction protocols. Therefore, this study focused on the optimization of microwave‐assisted extraction (MAE) process variables using Face‐Centered Central Composite Design (FC‐CCD). Then, maceration was applied as a conventional technique, and these techniques were compared in terms of extraction efficiency, morphological changes, antimicrobial activities, carbon emissions, and energy consumption. As a result, optimal MAE conditions, i.e., EtOH: water ratio (X1) = 100:0, liquid/sample ratio (X2) = 30:1 mL/g, microwave power (X3) = 300 W, and irradiation time (X4) = 5 min, were obtained with AL and IAL yields of 54.99 ± 0.11 (mg/g) and 48.40 ± 0.19 (mg/g), respectively. The extract obtained by MAE had similar or better activity than positive controls in most cases and formed the largest inhibition zones against E. coli (29.5 ± 0.71 mm) and A. niger (34.75 ± 1.06 mm). Morphological changes of I. helenium roots after extraction were observed by scanning electron microscopy. Additionally, MAE was 43.4 times faster than maceration, resulting in 228.6 times less energy consumption and carbon emissions. Based on these findings, it is recommended to use MAE as an industrial green technique for the extraction of sesquiterpene lactones with potential applications in nutraceuticals and food products in terms of sustainable economy and environmental protection.
dcSBM: A federated constrained source‐based morphometry approach for multivariate brain structure mapping
Authors: Saha Debbrata K. , Silva Rogers F. , Baker Bradley T. , Saha Rekha , Calhoun Vince D. 
Published: October 2023

AbstractThe examination of multivariate brain morphometry patterns has gained attention in recent years, especially for their powerful exploratory capabilities in the study of differences between patients and controls. Among the many existing methods and tools for the analysis of brain anatomy based on structural magnetic resonance imaging data, data‐driven source‐based morphometry (SBM) focuses on the exploratory detection of such patterns. Here, we implement a semi‐blind extension of SBM, called constrained source‐based morphometry (constrained SBM), which enables the extraction of maximally independent reference‐alike sources using the constrained independent component analysis (ICA) approach. To do this, we combine SBM with a set of reference components covering the full brain, derived from a large independent data set (UKBiobank), to provide a fully automated SBM framework. This also allows us to implement a federated version of constrained SBM (cSBM) to allow analysis of data that is not locally accessible. In our proposed decentralized constrained source‐based morphometry (dcSBM), the original data never leaves the local site. Each site operates constrained ICA on its private local data using a common distributed computation platform. Next, an aggregator/master node aggregates the results estimated from each local site and applies statistical analysis to estimate the significance of the sources. Finally, we utilize two additional multisite patient data sets to validate our model by comparing the resulting group difference estimates from both cSBM and dcSBM.
Improving the diagnosis of endometriosis in Asia‐Pacific: Consensus from the Asia‐Pacific Endometriosis Expert Panel for Endometriosis
Authors: Yen Chih‐Feng , Hamdan Mukhri , Hengrasmee Pattaya , Huang Zhongwei , Jeong Kyungah , Dao Le Anh , Lertvikool Srithean , Mogan Surita , Pal Bhaskar , Sumapradja Kanadi , Wu Meng‐Hsing , Yap‐Garcia Maria Isidora Margarita , Donovan Catherine , Christopher Stephen , Kim Mee‐Ran 
Published: October 2023

AbstractEndometriosis should be diagnosed as early as possible in the continuum of care; but substantial delays of approximately 6–8 years between symptom onset and endometriosis diagnosis have been widely reported. With the purpose of improving the prompt diagnosis of endometriosis, the Asia‐Pacific Endometriosis Expert Panel (APEX) sought to address the reasons for diagnostic delays across the region, and formulate a multi‐pronged approach to overcoming these challenges. In the first instance, clinical diagnosis is preferable to surgical diagnosis, in order to facilitate earlier empirical treatment and minimize the negative sequelae of undiagnosed/untreated disease. There should be a high clinical index of suspicion in women presenting with cyclical symptoms, including those involving extrapelvic organs. Diagnostic delays in Asia‐Pacific countries are attributable to a variety of patient, physician, and healthcare factors, including poor awareness, normalization/trivialization of pain, individual/cultural attitudes toward menstruation, default use of symptom‐suppressing treatments, misdiagnosis, and a lack of diagnostic resourcing or adequate referral pathways in some areas. Suggested initiatives to reduce diagnostic delays are geared toward improving public awareness, improving clinical diagnostic skills, streamlining multidisciplinary care pathways for timely referral, updating and implementing diagnostic guidelines, lobbying policymakers and insurance companies for endometriosis support, and increasing efforts to bridge data gaps and perform further research in this field. Formulating specific action plans and gathering traction are the responsibility of individual countries within local parameters. The APEX group advocates for any initiatives and policies that support the unmet needs of women with endometriosis, to improve patient experience and outcomes.
Genotoxicity of bisphenol AF in rats: Detrimental to male reproductive system and probable stronger micronucleus induction potency than BPA
Authors: Zhu Xia , Cao Li , Liu Yufei , Tang Xinyao , Miao Yeqiu , Zhang Jing , Zhang Lishi , Jia Zhenchao , Chen Jinyao 
Published: October 2023

AbstractBisphenol AF (BPAF), as one of structural analogs of BPA, has been increasingly used in recent years. However, limited studies have suggested its adverse effects similar to or higher than BPA. In order to explore the general toxicity and genotoxicity of subacute exposure to BPAF, the novel 28‐day multi‐endpoint (Pig‐a assay + micronucleus [MN] test + comet assay) genotoxicity evaluation platform was applied. Male rats were randomly distributed into seven main experimental groups and four satellite groups. The main experimental groups included BPAF‐treated groups (0.5, 5, and 50 μg/kg·bw/d), BPA group (10 μg/kg·bw/d), two solvent control groups (PBS and 0.1% ethanol/99.9% oil), and one positive control group (N‐ethyl‐N‐nitrosourea, 40 mg/kg bw). The satellite groups included BPAF high‐dose recovery group (BPAF‐HR), oil recovery group (oil‐R), ENU recovery group (ENU‐R), and PBS recovery group (PBS‐R). All groups received the agents orally via gavage for 28 consecutive days, and satellite groups were given a recovery period of 35 days. Among all histopathologically examined organs, testis and epididymis damage was noticed, which was further manifested as blood‐testis barrier (BTB) junction protein (Connexin 43 and Occludin) destruction. BPAF can induce micronucleus production and DNA damage, but the genotoxic injury can be repaired after the recovery period. The expression of DNA repair gene OGG1 was downregulated by BPAF. To summarize, under the design of this experiment, male reproductive toxicity of BPAF was noticed, which is similar to that of BPA, but its ability to induce micronucleus production may be stronger than that of BPA.
Ultrathin atomic layer deposition Al2O3 coatings on graphite cathode materials for improving anti‐self‐discharging Al‐ion battery
Authors: Gowdru Swathi M. , Wu Yu‐Cheng , Liu Ting‐Ran , Patil Shivaraj B. , Li Zhi‐Jie , Hsieh Han‐Hsuan , Chen Zhen , Wen Cheng‐Yen , Wang Di‐Yan 
Published: October 2023

AbstractObjectivesSelf‐discharging is a natural behavior that occurs in all batteries. In this work, to reduce the self‐discharging behavior of Al‐ion battery, the graphite materials were coated with different thickness of Al2O3 coatings (3, 5, 7, and 10 nm) by using atomic layer deposition (ALD) technique. Because there is no solid electrolyte interface (SEI) formed in Al‐ion battery with using ionic liquid electrolyte, ALD–Al2O3 coating could play a role in artificial SEI in Al‐ion battery.MethodsThe aluminum oxide (Al2O3) layer on the graphite electrode was deposited via ALD. During the deposition, the growth temperature for Al2O3 was kept at 80°C. High‐purity N2 was used to carry the gas precursors of trimethylaluminium Al2(CH3)6 (TMA) and H2O alternately into the reacting chamber of ALD. Each injection of gas precursor was followed by purging the reacting chamber with high‐purity N2. By controlling different reaction times, the different thickness of ALD–Al2O3 coatings on the surface of graphite materials can be obtained.ResultsWe found that SP1 graphite coated with 5 nm Al2O3 (SG–ALD‐5 nm) as cathode materials in Al‐ion battery exhibited a superior anti‐self‐discharging behavior (260 h) with long stability (∼900 cycles). The battery capacity can achieve up to 85 mAh/g at a current density of 300 mA/g (3C) with a coulombic efficiency (CE) of 98.5%. Furthermore, the ALD–Al2O3 coating method can also be applied to other graphite materials. The battery based on flexuous graphite with an ALD–Al2O3 coating (FG–ALD) also exhibited excellent discharging capacity of 140 mAh/g with good cycle stability over 3000 cycles at a current density of 3000 mA/g.ConclusionOverall results indicated that ALD coatings on graphite materials demonstrated significantly promising on not only reducing the self‐discharging problem but also remaining the superior battery performance.
Harmonization of distributed multi‐center analysis based on dried blood spot reference materials supporting the screening of neonatal inherited metabolic disorders
Authors: Qu Shou‐Fang , Tao Hao‐Ran , Qin Liu‐Ji , Zhang Wen‐Xin , Han Shan , Zhang Shen‐Yan , Huang Jie 
Published: October 2023

AbstractBackgroundThe standardization of quantification data is critical for ensuring the reliability and measurement traceability in the screening of neonatal inherited metabolic disorders. However, the availability of national certified reference materials is limited in China.MethodsIn this study, we developed a series of dried blood spot (DBS) reference materials containing 9 amino acids (AA) and 10 acylcarnitines (AC) for neonatal screening. Four levels of the reference materials were measured with tandem mass spectrometry (MS/MS) by seven laboratories using different commercial In Vitro Diagnostic Device (IVD) kits. Then, 100 clinical samples were measured using both derivatization and non‐derivatization methods by the same laboratory.ResultsWe found high homogeneity and stability at all levels of the reference materials, with the coefficient of variation (CV) of the analytes less than 15%. These reference materials can be used to assess the testing capabilities of different laboratories. Our test also revealed that the correction factors (CF) calculated by the reference materials, along with clinical samples, could increase the consistency for different kits.ConclusionThe DBS reference materials proposed in this study provide reliability for the harmonization in multi‐center analysis for the screening of neonatal inherited metabolic disorders. And applying our correction method for the screening could improve the data consistency of the DBS samples prepared by different methods.
Longitudinal effects of two individual career counseling interventions on clients’ career decision‐making during the COVID‐19 pandemic over a 1‐year follow‐up
Authors: Milot‐Lapointe Francis , Corff Yann Le 
Published: October 2023

AbstractThis study assessed the effects of two individual career counseling interventions during the COVID‐19 pandemic over a 1‐year follow‐up. Participants (n = 71) engaged either in four individual humanistic–psychodynamic (during winter 2021) or cognitive career counseling (during winter 2022) sessions at a university counseling clinic. Latent growth models indicated that clients experienced a significant reduction in their career decision difficulties and psychological distress and a significant increase in their life satisfaction over sessions and the 12 months following. Clients who received cognitive career counseling sessions experienced larger effects. Results highlight the utility of individual career counseling in times of crisis.
Cadaveric Assessment of the Butterfly Graft in Rhinoplasty
Authors: Brownlee Benjamin P. , Hassoun Adam , Parikh Aniruddha , Chen Xi Sophia , Zhao Daniel , Mims Mark M. 
Published: October 2023

IntroductionThe rhinoplasty butterfly graft is used to improve the internal nasal valve (INV), but post‐operative visibility remains a concern. Intraoperative techniques have developed to thin the graft with unknown effect on functionality.ObjectivesImprove understanding of how to modify the aesthetics of the butterfly graft without impacting patient outcomes. Determine how graft contouring affects its biomechanical properties.MethodsCadaveric cartilage grafts were used to examine the biomechanics in its native state and with progressive thinning. The force needed to stabilize the INV in an unaltered state and the resistance force provided by native (original), partially thinned, and fully thinned cartilage grafts were recorded.ResultsThe mean thickness of grafts in their natural state was 1.64 mm, median 1.50 mm (SD 0.64 mm). The fully‐thinned mean was 0.84 mm, median 0.8 mm (SD 0.18 mm). The mean force (N) of the native graft was 0.74 N and 0.60 N for fully thin (p = 0.016, 95%). The mean force (N) needed to stabilize the INV was 0.15 N (right) and 0.19 N (left).ConclusionButterfly grafts can be thinned by approximately 50% of their original thickness and retain the strength to stabilize the INV.Level of EvidenceNA Laryngoscope, 134:1638–1641, 2024
Exposure to TiO2 nanoparticles improves the physiological characteristics of drought‐challenged chickpeas (Cicer arietinum L.)
Authors: Ghorbani Roya , Ganjeali Ali , Movafeghi Ali , Nabati Jafar 
Published: October 2023

AbstractDrought stress markedly affects plant growth and crop production. In turn, treatment with some metal‐based nanoparticles (NPs) such as TiO2‐NPs could improve the plant tolerance against drought stress. In the present study, the effects of different levels of moisture regime (40%, 60%, and 90% field capacity [FC]) in conjunction with various concentrations of TiO2‐NPs (0, 5, 10, 20, and 40 mg. L−1) on chickpea were studied. Exposure of drought‐challenged chickpea plants to TiO2‐NPs raised antioxidant enzyme activity compared with plants grown under drought without TiO2‐NP treatment. The highest activity of ascorbate peroxidase (APX) was observed at 40% FC and application of 40 mg. L−1 TiO2‐NPs. Moreover, peroxidase (POX) activity has increased with the enhancing concentration of TiO2‐NPs to 20 mg. L−1 at 90% FC. In comparison, the application of 40 mg. L−1 TiO2‐NPs and decreasing levels of FC caused a rise in the activity of superoxide dismutase (SOD). Exposure to TiO2‐NPs raised the amount of total phenols and 2,2‐diphenyl‐1‐picryl‐hydrazyl‐hydrate (DPPH) at different levels of moisture regime. The content of malondialdehyde (MDA) at 60% FC has decreased by 22% after treatment with 20 mg. L−1 TiO2‐NPs compared with control plants. Also, treatment with TiO2‐NPs heightened the proline content, and the highest amount of proline was obtained at 40% FC by applying 20 mg. L−1 NPs. The treatment with TiO2‐NPs in the moisture regimes led to higher chlorophyll and carotenoid production in chickpea plants. Taken together, the application of TiO2‐NPs could raise the defense potential of chickpea plants against oxidative stress caused by the generation of reactive oxygen species.
Relative importance of bacterivorous mixotrophs in an estuary‐coast environment
Authors: Li Qian , Dong Kaiyi , Wang Ying , Edwards Kyle F. 
Published: October 2023

AbstractMixotrophic eukaryotes are important bacterivores in oligotrophic open oceans, but their significance as grazers in more nutrient‐rich waters is less clear. Here, we investigated the bacterivory partition between mixotrophs and heterotrophs in a productive, estuary‐influenced coastal region in the East China Sea. We found ubiquitous, actively feeding phytoplankton populations and taxa with mixotrophic potential by identifying ingestion of fluorescent prey surrogate and analyzing community 18S rRNA gene amplicons. Potential and active mixotrophs accounted for 10–63% of the total eukaryotic community and 17–69% of bacterivores observed, respectively, contributing 6–48% of estimated in situ bacterivory. The much higher mixotroph fitness outside of the turbid plume was potentially driven by increased light and decreased nutrient availability. Our results suggest that, although heterotrophs dominated overall in situ bacterivory, mixotrophs were abundant and important bacterivores in this low‐latitude mesotrophic coastal region.
Crosslinking of Epoxidized Natural Rubber with Borax for Self‐Healing and Self‐Repairing Properties: pH Dependence
Authors: Chantaramanee Tamonwan , Tanpichai Supachok , Boonmahitthisud Anyaporn 
Published: October 2023

AbstractEpoxidized natural rubber (ENR) crosslinked using borax, which exhibits self‐healing and self‐repairing properties, is successfully developed. The crosslink formation of ENR by using borax under neutral and alkaline conditions is investigated. Fourier transform infrared spectroscopy (FTIR) shows that the borate–ester bond is formed in ENR prepared under both neutral and alkaline conditions, whereas boron nuclear magnetic resonance (11B‐NMR) results exhibit that the ENR prepared under alkaline conditions more actively forms crosslink networks with borax. Moreover, the crosslink density and gel content increase significantly with the presence of borax in alkaline conditions. The crosslink density and gel content of ENR with 10 phr borax are higher by 155% and 36%, respectively, than those of neat ENR. Furthermore, the formation of the crosslinking ENR by borax enhances self‐healing and self‐repairing properties. The healing efficiency significantly increases from 1.09% to 85.90%, when ENR is developed under alkaline conditions with 30 phr borax. These results represent the first successful demonstration of the efficient use of borax as a crosslinker in ENR, which exhibits its promising self‐healing and self‐repairing properties under atmospheric conditions without the need for external stimuli. The ENR prepared in this work holds great promise for various self‐healing rubber applications.
Patient access to first contact practitioner physiotherapists in the UK: A national survey
Authors: Lamb Kirsten , Comer Christine , Walsh Nicola , McHugh Gretl 
Published: October 2023

AbstractBackgroundFirst Contact Practice Physiotherapists (FCPPs) offer expert care for patients with musculoskeletal (MSK) conditions in Primary Care, usually within GP practices. This is a rapidly expanding area of practice endorsed by NHS England, the Chartered Society of Physiotherapy (CSP) and the British Medical Association (BMA). Efficient and appropriate access is important for optimising FCPP practice, but there is little published information about how patients currently access FCPP appointments.ObjectiveTo investigate how patients access FCPP appointments in General Practice.DesignCross‐sectional online survey of FCPPs in the UK.MethodsFCPPs were surveyed about patient access to appointments. The survey instrument was designed using Jisc Online Surveys, piloted, and then distributed via social media and professional groups to FCPPs nationwide. Descriptive statistics were used to analyse demographic and multiple‐choice questions, and free text responses were analysed using quantitative content analysis.Results193 participants completed the survey. Booking via GP Reception (n = 179) was reported as the most common route into an FCPP appointment, closely followed by booking after seeing another clinician for the problem (n = 172).ConclusionThis research has provided clarity regarding how patients access the rapidly growing speciality of FCPP within GP practices in the UK. The role of GP Reception staff in facilitating access to FCPPs, the application of triage and the use of digital or online systems were highlighted as important elements for enabling efficient access to FCPPs by patients with MSK conditions.