bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoration the kinematics of mandibular movements by the method of hardware mechanotherapy in the protocol of functional rehabilitation for patients with TMJ’s diseases and myofascial pain syndrome
Authors: Шипика Д.В. , Баговиев А.Д. , Попова К.А. , Дарханова А.Е. , Дробышев А.Ю. 
Published: February 2024

Цели — разработка алгоритма восстановления кинематики движений нижней челюсти методом аппаратной механотерапии, оценка эффективности его применения у пациентов с заболеваниями височно-нижнечелюстного сустава (ВНЧС) и миофасциальным болевым синдромом. Методом аппаратной механотерапии проведено лечение 34 пациентов с болью в области ВНЧС, с ограничением открывания рта до 39 мм при физиологической норме 40—45 мм и внутренними нарушениями ВНЧС по данным МРТ. До лечения и на 7-е, 14-е и 21-е сутки измеряли выраженность болевого синдрома, величину открывания рта, по данным электромиографии вычисляли индекс IMPACT (гипертонус жевательной мускулатуры). На 21-е сутки открывание рта увеличилось на 12,2±2,3 мм (38,75%) от исходных значений, индекс IMPACT снизился на 502±292 мкВ (11,2%) мкВ, выраженность болевого синдрома по ВАШ уменьшилась на 5,0±0,5 балла (99%). Аппаратная механотерапия способствует скорейшему восстановлению физиологической кинематики движений нижней челюсти, купированию болевого синдрома и нормализации биоэлектрической активности жевательной мускулатуры. Предложенный метод можно рекомендовать к применению при лечении пациентов с ограничением открывания рта, миофасциальным болевым синдромом, заболеваниями ВНЧС.
Objectives — design an algorithm for restoring the kinematics of lower jaw movements by the method of hardware mechanotherapy, to evaluate the effectiveness of its use in patients with TMJ diseases and myofascial pain syndrome. . Thirty-four patients diagnosed with TMJ pain, limited mouth opening of up to 39 mm (the physiological norm is 40—45 mm), and internal TMJ disorders based on MRI data were treated with apparatus mechanotherapy. Pain syndrome severity, mouth opening value, and the IMPACT index (masticatory muscle hypertonicity) were measured before treatment and on the 7th, 14th, and 21st days using EMG data. . On the twenty-first day, there was a 38.7% increase of 12.2±2.3mm in mouth opening when compared to initial values. Additionally, there was an IMPACT index reduction of 502±292 μV (11.2% reduction) and a decrease of 5.0±0.5 points (99% decrease) in the severity of pain syndrome according to VAS. . Based on the research’s results we can recommend the method of hardware mechanotherapy to using in the protocol of treatment of patients with reduced mouth opening, myofascial pain syndrome, TMJ diseases. Hardware mechanotherapy promotes to the speedy restoration of the physiological kinematics of the movements of the lower jaw, relief of pain syndrome and normalization of the bioelectric activity of the chewing muscles.
Firmamento: A Multimessenger Astronomy Tool for Citizen and Professional Scientists
Authors: Tripathi Dhurba , Giommi Paolo , Di Giovanni Adriano , Almansoori Rawdha R. , Al Hamly Nouf , Arneodo Francesco , Macciò Andrea V. , Puccetti Goffredo , Barres de Almeida Ulisses , Brandt Carlos , Di Pippo Simonetta , Doro Michele , Israyelyan Davit , Pollock A. M. T. , Sahakyan Narek 
Published: February 2024

Abstract

Firmamento (https://firmamento.hosting.nyu.edu) is a new-concept, web-based, and mobile-friendly data analysis tool dedicated to multifrequency/multimessenger emitters, as exemplified by blazars. Although initially intended to support a citizen researcher project at New York University–Abu Dhabi, Firmamento has evolved to be a valuable tool for professional researchers due to its broad accessibility to classical and contemporary multifrequency open data sets. From this perspective Firmamento facilitates the identification of new blazars and other multifrequency emitters in the localization uncertainty regions of sources detected by current and planned observatories such as Fermi-LAT, Swift, eROSITA, CTA, ASTRI Mini-Array, LHAASO, IceCube, KM3Net, SWGO, etc. The multiepoch and multiwavelength data that Firmamento retrieves from over 90 remote and local catalogs and databases can be used to characterize the spectral energy distribution and the variability properties of cosmic sources as well as to constrain physical models. Firmamento distinguishes itself from other online platforms due to its high specialization, the use of machine learning and other methodologies to characterize the data, and for its commitment to inclusivity. From this particular perspective, its objective is to assist both researchers and citizens interested in science, strengthening a trend that is bound to gain momentum in the coming years as data retrieval facilities improve in power and machine-learning/artificial-intelligence tools become more widely available.
Predicting the Arrival Time of an Interplanetary Shock Based on DSRT Spectrum Observations for the Corresponding Type II Radio Burst and a Blast Wave Theory
Authors: Li 李 Ran 冉 , Zhao 赵 Xinhua 新华 , Yan 阎 Jingye 敬业 , Wu 武 Lin 林 , Yang 杨 Yang 洋 , Lv 吕 Xuning 旭宁 , Feng 冯 Shiwei 士伟 , Ruan 阮 Mengsi 梦思 , Xiang 向 Nanbin 南彬 , Liang 梁 Yidan 一丹 
Published: February 2024

Abstract
Since fast head-on coronal mass ejections and their associated shocks represent potential hazards to the space environment of the Earth and even other planets, forecasting the arrival time of the corresponding interplanetary shock is a priority in space weather research and prediction. Based on the radio spectrum observations of the 16-element array of the Daocheng Solar Radio Telescope (DSRT), the flagship instrument of the Meridian Project of China, during its construction, this study determines the initial shock speed of a type II solar radio burst on 2022 April 17 from its drifting speed in the spectrum. Assuming that the shock travels at a steady speed during the piston-driven phase (determined from the X-ray flux of the associated flare) and then propagates through interplanetary space as a blast wave, we estimate the propagation and arrival time of the corresponding shock at the orbit of the Solar Terrestrial Relations Observatory-A (STEREO-A). The prediction shows that the shock will reach STEREO-A at 14:31:57 UT on 2022 April 19. The STEREO-A satellite detected an interplanetary shock at 13:52:12 UT on the same day. The discrepancy between the predicted and observed arrival time of the shock is only 0.66 hr. The purpose of this paper is to establish a general method for predicting the shock’s propagation and arrival time from this example, which will be utilized to predict more events in the future based on the observations of ground-based solar radio spectrometers or telescopes like DSRT.
Inferring the Solar Wind Velocity in the Outer Corona Based on Multiview Observations of Small-scale Transients by STEREO/COR2
Authors: Lyu Shaoyu , Wang Yuming , Li Xiaolei , Zhang Quanhao , Liu Jiajia 
Published: February 2024

Abstract
Based on the Heliospheric Imager-1 images of the STEREO twin spacecraft, we established the CORrelation-Aided Reconstruction (CORAR) technique to locate and reconstruct the 3D structures of solar wind transients in interplanetary space. Here, we extend the CORAR method to images of COR2 on board STEREO to study the evolution of small-scale transients in the outer corona from 2010 January to May. We confirm that the transients can be located and reconstructed well by comparing the results with those of a self-similar expanding model. The speed distribution of the reconstructed transients generally shows the typical characteristics of the slow solar wind. We further study the sources of the transients on the Sun, and find that most reconstructed transients are located near the top of streamer belts or the heliospheric current sheet and can be tracked back to the boundaries of the closed-field and open-field regions along the field lines extrapolated by corona models. The formation mechanisms of these transients in the slow solar wind are also discussed.
Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection
Authors: Pandori William J , Matsuno Stephanie Y , Shin Ji-Hun , Kim Samuel C , Kao Tiffany H , Mallya Sharmila , Batarseh Sarah N , Lodoen Melissa B 
Published: February 2024

Abstract
Monocytes are actively recruited to sites of infection and produce the potent proinflammatory cytokine IL-1β. We previously showed that IL-1β release during Toxoplasma gondii infection of primary human monocytes requires the NLRP3 inflammasome and caspase-1 but is independent of gasdermin D and pyroptosis. To investigate mechanisms of IL-1β release, we generated caspase-1, -4, -5, or -8 knockout (KO) THP-1 monocytic cells. Genetic ablation of caspase-1 or -8, but not caspase-4 or -5, decreased IL-1β release during T. gondii infection without affecting cell death. In contrast, TNF-α and IL-6 secretion were unperturbed in caspase-8 KO cells during T. gondii infection. Dual pharmacological inhibition of caspase-8 and RIPK1 in primary monocytes also decreased IL-1β release without affecting cell viability or parasite infection. Caspase-8 was also required for the release of active caspase-1 from T. gondii–infected cells and for IL-1β release during infection with the related apicomplexan parasite Neospora caninum. Surprisingly, caspase-8 deficiency did not impair synthesis or cleavage of pro–IL-1β, but resulted in the retention of mature IL-1β within cells. Generation of gasdermin E KO and ATG7 KO THP-1 cells revealed that the release of IL-1β was not dependent on gasdermin E or ATG7. Collectively, our data indicate that during T. gondii Infection of human monocytes, caspase-8 functions in a novel gasdermin-independent mechanism controlling IL-1β release from viable cells. This study expands on the molecular pathways that promote IL-1β in human immune cells and provides evidence of a role for caspase-8 in the mechanism of IL-1β release during infection.
Molecular Interactions Required for Activation of Complement Component C2 Include Exosites Located on the Serine Protease Domain of C1s and Mannose-Binding Lectin Associated Protease-2
Authors: Hor Lilian , Pan Jing , Pike Robert N , Wijeyewickrema Lakshmi C 
Published: February 2024

Abstract
The activation of the CP/LP C3 proconvertase complex is a key event in complement activation and involves cleavage of C4 and C2 by the C1s protease (classical pathway) or the mannose-binding lectin–associated serine protease (MASP)-2 (lectin pathway). Efficient cleavage of C4 by C1s and MASP-2 involves exosites on the complement control protein and serine protease (SP) domains of the proteases. The complement control protein domain exosite is not involved in cleavage of C2 by the proteases, but the role of an anion-binding exosite (ABE) on the SP domains of the proteases has (to our knowledge) never been investigated. In this study, we have shown that the ABE on the SP of both C1s and MASP-2 is crucial for efficient cleavage of C2, with mutant forms of the proteases greatly impaired in their rate of cleavage of C2. We have additionally shown that the site of binding for the ABE of the proteases is very likely to be located on the von Willebrand factor domain of C2, with the precise area differing between the enzymes: whereas C1s requires two anionic clusters on the von Willebrand factor domain to enact efficient cleavage of C2, MASP-2 apparently only requires one. These data provide (to our knowledge) new information about the molecular determinants for efficient activation of C2 by C1s and MASP-2. The enhanced view of the molecular events underlying the early stages of complement activation provides further possible intervention points for control of this activation that is involved in a number of inflammatory diseases.
Critical Role of CD55 in Controlling Wound Healing
Authors: Kang Lorna , Kohen Maryo , McCarthy Isaac , Hammelef Emma , Kim Hae Suk , Bapputty R , Gubitosi-Klug Rose , Orge Faruk H , Kern Timothy , Medof M Edward 
Published: February 2024

Abstract
How reparative processes are coordinated following injury is incompletely understood. In recent studies, we showed that autocrine C3a and C5a receptor (C3ar1 and C5ar1) G protein–coupled receptor signaling plays an obligate role in vascular endothelial growth factor receptor 2 growth signaling in vascular endothelial cells. We documented the same interconnection for platelet-derived growth factor receptor growth signaling in smooth muscle cells, epidermal growth factor receptor growth signaling in epidermal cells, and fibroblast growth factor receptor signaling in fibroblasts, indicative of a generalized cell growth regulatory mechanism. In this study, we examined one physiological consequence of this signaling circuit. We found that disabling CD55 (also known as decay accelerating factor), which lifts restraint on autocrine C3ar1/C5ar1 signaling, concomitantly augments the growth of each cell type. The mechanism is heightened C3ar1/C5ar1 signaling resulting from the loss of CD55’s restraint jointly potentiating growth factor production by each cell type. Examination of the effect of lifted CD55 restraint in four types of injury (burn, corneal denudation, ear lobe puncture, and reengraftment of autologous skin) showed that disabled CD55 function robustly accelerated healing in all cases, whereas disabled C3ar1/C5ar1 signaling universally retarded it. In wild-type mice with burns or injured corneas, applying a mouse anti-mouse CD55 blocking Ab (against CD55’s active site) to wounds accelerated the healing rate by 40–70%. To our knowledge, these results provide new insights into mechanisms that underlie wound repair and open up a new tool for accelerating healing.
Wireless Patient Monitoring System Based on Smart Wristbands and Central user Interface Software
Authors: Vafaie Mohammad Hossein , Ahmadi Beni Ebrahim 
Published: February 2024

Abstract
In this article, a patient monitoring system is proposed that is able to obtain heart rate and oxygen saturation (SpO2) levels of patients, identify abnormal conditions, and inform emergency status to the nurses. The proposed monitoring system consists of smart patient wristbands, smart nurse wristbands, central monitoring user interface (UI) software, and a wireless communication network. In the proposed monitoring system, a unique smart wristband is dedicated to each of the patients and nurses. To measure heart rate and SpO2 level, a pulse oximeter sensor is used in the patient wristbands. The output of this sensor is transferred to the wristband’s microcontroller where heart rate and SpO2 are calculated through advanced signal processing algorithms. Then, the calculated values are transmitted to central UI software through a wireless network. In the UI software, received values are compared with their normal values and a predefined message is sent to the nurses’ wristband if an abnormal condition is identified. Whenever this message is received by a nurse’s wristband, an acoustic alarm with vibration is generated to inform an emergency status to the nurse. By doing so, health services are delivered to the patients more quickly and as a result, the probability of the patient recovery is increased effectively.
Experience with osteoplastic posterior fossa craniotomy in 13 children
Authors: Jaiswal Manish , Jaiswal Somil , Chandra Anil , Krishna Bal Ojha 
Published: February 2024

Abstract

Background:
Posterior fossa free bone flap craniotomy in children is being currently used, and it significantly decreases postoperative cerebrospinal fluid (CSF) leakage and pseudomeningoceles. However, sometimes bone displacement, bone resorption, osteonecrosis, or infection occurs in a few children after posterior fossa free bone flap craniotomy. So, in recent years, a few posterior fossa osteoplastic craniotomy techniques to overcome these complications have been described. Here, we are documenting our experiences with one of the previously described techniques of osteoplastic craniotomy, with some modification in cases of pediatric posterior fossa tumor. We called this described procedure “ligamentous osteoplastic midline posterior fossa craniotomy (LOM-PFC),” as it preserves the attachments of the posterior atlanto-occipital membrane.

Materials and Methods:
This LOM-PFC approach was implemented between 2018 and 2019 in 13 pediatric patients who were suffering from posterior fossa tumor. Perioperative and follow-up clinico-radiologic details were reviewed.

Results:
Only one patient had transient mild CSF accumulation, which was managed by lumbar punctures. A 3D reconstruction of computed tomography (CT) scan head verified a well-aligned and fused LOM-PFC flap during the postoperative and the follow-up period, respectively. Cosmetic results were excellent. The maximal follow-up period was one year.

Conclusions:
We found that the LOM-PFC approach had no added risk. It preserves the anatomy of the foramen magnum and allows more stable fixation of the bone flap, which minimizes the risk of CSF leakage, pseudomeningocele and finally reduces the hospital stay. This approach is easy to learn, feasible, and cosmetically effective.
Association of Ocular Injuries in Patients with Head Injury: A Tertiary-Level Armed Forces Experience
Authors: Maheshwari Vikas , Dhurvey Deepak K. , Singh Gurpreet 
Published: February 2024

ABSTRACT

Introduction:
The incidence of trauma is on an increasing trend worldwide. It has drastically increased due to urbanization, vehicular congestion, alcoholism, and poor infrastructure facilities, especially in developing countries. In the Armed Forces, the additional burden of trauma is also seen due to various unit activities, organized sports, and other adventure sports. Head injury cases are often associated with various ocular injuries. These ocular injuries, if subtle in nature, can be missed initially and progress into ophthalmological complications and rarely into permanent visual impairment. The aim of this study was to critically analyze the association of various ocular injuries in patients with head injury.

Materials and Methods:
A cross-sectional study was conducted in a tertiary-level Armed Forces Hospital from July 2016 to December 2018. A total of 40 patients were evaluated who had head injury along with ocular injuries. The Glasgow Coma Scale (GCS) was used to assess the severity of the head injury. Ocular manifestations such as subconjunctival hemorrhage, ecchymosis, soft tissue injuries such as lid tear, corneal injuries, and bony and associated nerve injuries were evaluated.

Results:
A total of 40 patients with head injury with ocular manifestations were studied. Road traffic accident (RTA) was the most common cause, followed by accidental fall from height and sports injuries. There was a male preponderance (n = 32 (80%)) over females (n = 8 (20%)). Unilateral ocular manifestation (n = 32 (80%)) was more common than bilateral involvement (n = 8 (20%)). The most frequent ocular manifestations were subconjunctival hemorrhage and ecchymosis (35 (87.5%)), followed by lid laceration (6 (15%)), corneal tear (04 (10%)), vitreous hemorrhage (01 (2.5%)), evisceration (2 (05%)), and cranial nerve injury (06 (12.5%)). Orbital wall fracture was seen in 15 (37.5%) patients, including lateral wall fracture (n = 08 (20%)), medial wall fracture (n = 04 (10%)), orbital floor fracture (n = 02 (05%)), and orbital roof fracture (n = 01 (2.5%)).

Conclusion:
Ocular injuries can occur in patients with head injury irrespective of the mode and kinematics involved (severe head injury may present with minimal ocular manifestations or vice versa). These patients require hospitalization, observation, thorough ophthalmic evaluation, and periodic assessment to minimize morbidity and complications.
Comparison of Static and Dynamic Myofascial Decompression on Gastrosoleus Muscle Power and Latent Trigger Point Pain in Normal Healthy Women
Authors: Baxi Gaurang D. , Keerthana R , Palekar Tushar J. , Gohil Divya , Deshmukh Mayura 
Published: February 2024

ABSTRACT

Objectives:
Muscle performance is an essential component of an individual that is influenced by physiological, anatomical, psychological, and biomechanical factors. It includes flexibility, muscle strength, agility, and cardiovascular and aerobic endurance. Treatment approaches like stretching and myofascial decompression help improve flexibility and thereby muscle performance. This study explores the effects of static and dynamic myofascial decompression on gastro soleus trigger point pain and power.

Materials and Methods:
105 healthy normal women in the age group of 20-30 yrs were enrolled in the study. The subjects were divided into three groups by simple random sampling using the chit method. Group A received static myofascial decompression, dynamic stretching, and cryotherapy. Group B received dynamic myofascial decompression, dynamic stretching, and cryotherapy whereas Group C received dynamic stretching and cryotherapy. Lower extremity muscle power and functional performance were tested by Vertical jump height. The Gastrosoleus muscle’s myofascial trigger point pain sensitivity was measured with a pressure algometer.

Statistical Analysis:
Data was analyzed using SPSS. The difference in the mean Vertical jump height and pain pressure threshold values between the groups were analyzed using one-way ANOVA. Intra-group analysis was done using Repeated Measures ANOVA. Statistical significance was set at P < 0.05, at a 95% confidence interval.

Results:
Participants in all three groups showed clinical improvement, however, the differences in the three groups were not statistically significant. In the dynamic myofascial decompression group, a significant (P < 0.05) carry-over effect was seen in the vertical jump height test post 5 days of intervention.

Conclusion:
Static and Dynamic myofascial decompression are equally effective in reducing pain and improving gastro soleus muscle power in subjects with latent trigger points. There was a sustained carry-over effect was seen in the vertical jump height test in the dynamic myofascial decompression group after 5 days of intervention.
Molecular appraisal of Giardia intestinalis from Western India: A prospective observational study
Authors: Mohammad Naila , Tak Vibhor , Bohra Gopal Krishna , Gadepalli Ravisekhar , Sharma Anuradha , Singh Kuldeep , Nag Vijaya Lakshmi 
Published: February 2024

Background:

Giardia intestinalis is an intestinal protozoan which commonly causes parasitic gastroenteritis globally. It is a species complex consisting of at least eight assemblages (genotypes). In India, Giardia is mostly underreported and missed in asymptomatic cases.

Aim:
The aim of this study was to genotype the G. intestinalis isolates from stool samples of patients at a tertiary care center in Rajasthan, India, and to clinically correlate it.

Methods:
This prospective pilot cross-sectional study was conducted from 2019 to 2021 in a tertiary care center in western India. Patients who were microscopically positive for giardiasis were enrolled. DNA was extracted from their stool samples and amplified by polymerase chain reaction (PCR) using 4E1-HP as the target sequence. Anthropometric measurements and analysis were done for children by using Anthrocal application.

Results:
A total of 50 patients were enrolled. Diarrhea was present in 18 patients (36%). Among these, 6 were immunocompromised and had different comorbidities. Among the children <12 years of age, 55.17% (n = 16/29) were stunted (<−2 S.D.), and among <5 years, 44.4% (n = 4/9) showed wasting (<−2 S.D.). A PCR product corresponding to assemblage B of G. intestinalis was amplified in 47 stool specimens. Only three stool samples were negative for both assemblages A and B and posed an interesting enigma.

Conclusion:
In this study, a predominance of assemblage B of G. intestinalis was detected in 94% of the isolates. Furthermore, the possibility of zoonotic transmission could not be ruled out.