bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 17-specific immune pathways are active in early spondyloarthritis
Authors: Hughes Catherine D , Ryan Sarah E , Steel Kathryn J A , van den Beukel Michelle D , Trouw L A , van Schie Karin A J , Toes René E M , Menon Bina , Kirkham Bruce W , Taams Leonie S 
Published: December 2023

ObjectiveUndifferentiated, early inflammatory arthritis (EIA) can differentiate into seropositive or seronegative rheumatoid arthritis (RA), peripheral spondyloarthritis (SpA) or remain as seronegative undifferentiated inflammatory arthritis (UIA). Little is known about immune pathways active in the early stages of SpA and seronegative UIA, in contrast to detailed knowledge of seropositive RA. The aim of this study was to examine if specific immune pathways were active in synovial CD4+ and CD8+ T cells in EIA.MethodsSynovial fluid (SF) samples from 30 patients with EIA were analysed for expression of IL-17A, IFNγ and TNFα in CD8+ or CD4+ T cells. Final clinical diagnoses were made at least 12 months after sample collection, by two independent clinicians blind to the study data.ResultsFlow cytometry analysis of all EIA samples indicated considerable variation in synovial IL-17A+CD8+ T cells (Tc17) cell frequencies between patients. The group with a final diagnosis of SpA (psoriatic arthritis or peripheral SpA, n=14) showed a significant enrichment in the percentage of synovial Tc17 cells compared with the group later diagnosed with seronegative UIA (n=10). The small number of patients later diagnosed with seropositive RA (n=6) patients had few Tc17 cells, similar to our previous findings in established disease. In contrast, RA SF contained a significantly higher percentage of CD8+IFNγ+ T cells compared with SpA or seronegative UIA.ConclusionThese results suggest that adaptive T cell cytokine pathways differ not only between RA and SpA but also seronegative UIA early in the disease process, with a particular activation of Tc17 pathways in early SpA.
Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort
Authors: Redeker Imke , Landewé Robert , van der Heijde Désirée , Ramiro Sofia , Boonen Annelies , Dougados Maxime , Braun Jürgen , Kiltz Uta 
Published: December 2023

ObjectiveThe objective of this study is to build a structural model visualising and quantifying the interrelationships of different disease outcomes with the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) in patients with axial spondyloarthritis (axSpA).MethodsCross-sectional data collected at month 72 of the Devenir des Spondylarthropathies Indifferénciées Récentes cohort was analysed. Combining prior knowledge and observed data, probabilistic Bayesian network modelling was used to study how the interplay of different disease outcomes affects the ASAS HI, which measures disease-specific overall functioning and health. Disease outcomes comprised, among others, the Ankylosing Spondylitis (AS) Disease Activity Score (ASDAS) and the Bath AS Functional Index (BASFI).ResultsData of 384 patients were analysed. The obtained structure suggests that ASAS HI is determined by both patient-reported physical function (BASFI) and disease activity (ASDAS). The parameters of the structural model show that an increase of ASDAS or BASFI by 1 unit corresponds to an increase of ASAS HI by 0.70 or 1.25 units, respectively. Moreover, the model suggests that disease activity has an indirect impact on ASAS HI via BASFI. No relationship between spinal mobility or structural damage and ASAS HI was found.ConclusionsThis is the first structural model developed to better understand the construct and the interplay between clinically relevant outcomes related to ASAS HI in axSpA patients. It shows that disease activity and physical function have a strong impact on ASAS HI, confirming it to be a valid construct of overall functioning and health in axSpA patients.
The s process in massive stars, a benchmark for neutron capture reaction rates
Authors: Pignatari Marco , Gallino Roberto , Reifarth Rene 
Published: December 2023

AbstractA clear definition of the contribution from the slow neutron-capture process (s process) to the solar abundances between Fe and the Sr-Zr region is a crucial challenge for nuclear astrophysics. Robust s-process predictions are necessary to disentangle the contribution from other stellar processes producing elements in the same mass region. Nuclear uncertainties are affecting s-process calculations, but most of the needed nuclear input are accessible to present nuclear experiments or they will be in the near future. Neutron-capture rates have a great impact on the s process in massive stars, which is a fundamental source for the solar abundances of the lighter s-process elements heavier than Fe (weak s-process component). In this work we present a new nuclear sensitivity study to explore the impact on the s process in massive stars of 86 neutron-capture rates, including all the reactions between C and Si and between Fe and Zr. We derive the impact of the rates at the end of the He-burning core and at the end of the C-burning shell, where the $$^{22}$$

22

Ne($$\alpha $$
α
,n)$$^{25}$$

25

Mg reaction is is the main neutron source. We confirm the relevance of the light isotopes capturing neutrons in competition with the Fe seeds as a crucial feature of the s process in massive stars. For heavy isotopes we study the propagation of the neutron-capture uncertainties, finding a clear difference of the impact of Fe and Co isotope rates with respect to the rates of heavier stable isotopes. The local uncertainty propagation due to the neutron-capture rates at the s-process branching points is also considered, discussing the example of $$^{85}$$

85

Kr. The complete results of our study for all the 86 neutron-capture rates are available online. Finally, we present the impact on the weak s process of the neutron-capture rates included in the new ASTRAL library (v0.2).
A Review of Recent Advances in the Molecular Mechanisms Underlying Brain Metastasis in Lung Cancer
Authors: Guan Chao , Zhang Xiaoye , Yu Li 
Published: December 2023

Abstract
Brain metastasis from lung cancer is a prevalent mode of treatment failure associated with a poor prognosis. The incidence of brain metastasis has recently shown a dramatic increase. The early detection and risk stratification of lung cancer–related brain metastasis would be highly advantageous for patients. However, our current knowledge and comprehension of the underlying mechanisms driving brain metastasis in lung cancer pose significant challenges. This review summarizes the mechanisms underlying brain metastasis, focusing on the intricate interplay between lung cancer–derived tumor cells and the unique characteristics of the brain, recent advancements in the identification of driver genes, concomitant genes, epigenetic features, including miRNAs and long noncoding RNAs, as well as the molecular characterization of brain metastasis originating from other organs, which may further enhance risk stratification and facilitate precise treatment strategies.
Combined Technique for Internal Carotid Artery Terminus or Middle Cerebral Artery Occlusions in the ASTER2 Trial
Authors: Sgreccia Alessandro , Desilles Jean-Philippe , Costalat Vincent , Dargazanli Cyril , Bourcier Romain , Tessier Guillaume , Rouchaud Aymeric , Saleme Suzana , Spelle Laurent , Caroff Jildaz , Marnat Gaultier , Barreau Xavier , Clarençon Frédéric , Shotar Eimad , Eugene François , Houdart Emmanuel , Gory Benjamin , Zhu François , Labreuche Julien , Piotin Michel , Lapergue Bertrand , Consoli Arturo , Blanc Raphael , Redjem Hocine , Ciccio Gabriele , Smajda Stanislas , Mazighi Mikael , Fahed Robert , Rodesch Georges , Coskun Oguzhan , Di Maria Federico , Bourdain Frédéric , Decroix Jean Pierre , Wang Adrien , Tchikviladze Maya , Evrard Serge , Turjman Francis , Labeyrie Paul Emile , Riva Roberto , Mounayer Charbel , Saleme Suzana , Costalat Vincent , Bonafé Alain , Eker Omer , Gascou Grégory , Bracard Serge , Tonnelet Romain , Derelle Anne Laure , Anxionnat René , Desal Hubert , Daumas-Duport B. , Berge Jérome , Barreau Xavier , Djemmane Lynda , Labreuche Julien , Duhamel. Alain 
Published: December 2023

BACKGROUND:
The aim of this study was to report the results of a subgroup analysis of the ASTER2 trial (Effect of Thrombectomy With Combined Contact Aspiration and Stent Retriever vs Stent Retriever Alone on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion) comparing the safety and efficacy of the combined technique (CoT) and stent retriever as a first-line approach in internal carotid artery (ICA) terminus±M1-middle cerebral artery (M1-MCA) and isolated M1-MCA occlusions.

METHODS:
Patients enrolled in the ASTER2 trial with ICA terminus±M1-MCA and isolated M1-MCA occlusions were included in this subgroup analysis. The effect of first-line CoT versus stent retriever according to the occlusion site was assessed on angiographic (first-pass effect, expanded Treatment in Cerebral Infarction score ≥2b50, and expanded Treatment in Cerebral Infarction score ≥2c grades at the end of the first-line strategy and at the end of the procedure) and clinicoradiological outcomes (24-hour National Institutes of Health Stroke Scale, ECASS-III [European Cooperative Acute Stroke Study] grades, and 3-month modified Rankin Scale).

RESULTS:
Three hundred sixty-two patients were included in the postsubgroup analysis according to the occlusion site: 299 were treated for isolated M1-MCA occlusion (150 with first-line CoT) and 63 were treated for ICA terminus±M1-MCA occlusion (30 with first-line CoT). Expanded Treatment in Cerebral Infarction score ≥2b50 (odds ratio, 11.83 [95% CI, 2.32–60.12]) and expanded Treatment in Cerebral Infarction score ≥2c (odds ratio, 4.09 [95% CI, 1.39–11.94]) were significantly higher in first-line CoT compared with first-line stent retriever in patients with ICA terminus±M1-MCA occlusion but not in patients with isolated M1-MCA.

CONCLUSIONS:
First-line CoT was associated with higher reperfusion grades in patients with ICA terminus±M1-MCA at the end of the procedure.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03290885.
Diversity of wood colour in tropical timber species and its relationship with wood density and anatomical features
Authors: Bessa Fernanda , Sousa Vicelina , Quilhó Teresa , Pereira Helena 
Published: December 2023

Summary
The wood colour variability of 98 tropical species from India (Goa), Mozambique and East Timor was described using CIELab colour parameters and related to wood density and anatomical features. Wood colours were mostly light and yellowish, ranging from 24.0–84.4 for wood lightness, 2.6–20.4 for redness, 1.8–36.6 for yellowness, 2.1–35.9 for chromaticity and 27.5–81.6 for hue angle. Among the colour parameters, the positive correlation between L* and b* was the most significant, followed by a negative correlation between L* and a*, while the positive correlation between a* and b* was non-significant. Positive correlations between L* and both h and C* were also highly significant. CIELab colour parameters were significantly correlated to wood density, the stronger negative correlation was found with L*, followed by the negative correlation with b*. Wood colour was not strongly correlated with the quantitative anatomical features studied showing only weak negative correlations between L* and the fibre wall thickness/fibre width ratio and between b* and fibre length. Wood density was correlated to almost all anatomical features showing the strongest correlations with fibre wall thickness/fibre width ratio and fibre width. The darker-coloured tropical woods showed high wood density, high fibre wall proportion, high vessel frequency and narrow vessels compared to the lighter coloured woods. Overall, wood colour diversity of tropical species could contribute to increase the international timber market by including lesser-known species, which would enhance local development and sustainability of endangered tropical species.
Expanding donor options: haploidentical transplant recipients are also highly likely to have a 7/8-matched unrelated donor
Authors: Fingerson Stephanie , Maiers Martin , Bolon Yung-Tsi , Devine Steven M. , Spellman Stephen R. 
Published: December 2023

Abstract
The use of haploidentical related donor (HRD) hematopoietic cell transplants (HCTs) in the United States grew by more than fourfold in the last decade, driven mainly by use of posttransplant cyclophosphamide (PTCy)-based graft-versus-host-disease prophylaxis. However, not all patients have a suitable HRD available. In this study, we explored the existence of unrelated donors (URDs) on the National Marrow Donor Program (NMDP) registry at the 8/8- or 7/8-match level for patients receiving HRD HCT in the United States and reporting to the Center for International Blood and Marrow Transplant Research between 2013 and 2020. The data consist of 9696 HRD HCT recipients. The NMDP search prognosis score and a search simulation were used to estimate counts of URD matches on the registry. NMDP search prognosis varied by patient ancestry, with 27.5% non-Hispanic White having a good score compared with 4.6% of African American HRD HCT recipients. Overall, 34% of recipients had ≥1 8/8-matched URDs and 84% had ≥1 7/8 URDs. Recipients of older HRDs (≥35 years) had a likelihood of between 20%- 65% of having ≥5 existing 7/8-matched URDs who were aged ≤35 years. Donor-selection practices varied among the 10 highest-volume HRD centers: 6 had &gt;20% chance of an existing 8/8-matched URD for their HRD recipients, whereas 4 centers had low likelihood of identifying an 8/8-matched URD. In conclusion, although most US patients undergoing HRD HCT do not have an existing 8/8 URD, the majority have an existing 7/8-matched URD. Studies comparing outcomes in patients receiving either HRD or 7/8-matched URD HCT and PTCy-based graft-versus-host disease prophylaxis may be warranted.
Longitudinal genomic analyses of automatically-recorded vaginal temperature in lactating sows under heat stress conditions based on random regression models
Authors: Wen Hui , Johnson Jay S. , Freitas Pedro H. F. , Maskal Jacob M. , Gloria Leonardo S. , Araujo Andre C. , Pedrosa Victor B. , Tiezzi Francesco , Maltecca Christian , Huang Yijian , Schinckel Allan P. , Brito Luiz F. 
Published: December 2023

AbstractBackgroundAutomatic and continuous recording of vaginal temperature (TV) using wearable sensors causes minimal disruptions to animal behavior and can generate data that enable the evaluation of temporal body temperature variation under heat stress (HS) conditions. However, the genetic basis of TVin lactating sows from a longitudinal perspective is still unknown. The objectives of this study were to define statistical models and estimate genetic parameters for TVin lactating sows using random regression models, and identify genomic regions and candidate genes associated with HS indicators derived from automatically-recorded TV.ResultsHeritability estimates for TVranged from 0.14 to 0.20 over time (throughout the day and measurement period) and from 0.09 to 0.18 along environmental gradients (EG, − 3.5 to 2.2, which correspond to dew point values from 14.87 to 28.19 ˚C). Repeatability estimates of TVover time and along EG ranged from 0.57 to 0.66 and from 0.54 to 0.77, respectively. TVmeasured from 12h00 to 16h00 had moderately high estimates of heritability (0.20) and repeatability (0.64), indicating that this period might be the most suitable for recording TVfor genetic selection purposes. Significant genotype-by-environment interactions (GxE) were observed and the moderately high estimates of genetic correlations between pairs of extreme EG indicate potential re-ranking of selection candidates across EG. Two important genomic regions on chromosomes 10 (59.370–59.998 Mb) and16 (21.548–21.966 Mb) were identified. These regions harbor the genesCDC123,CAMK1d,SEC61A2, andNUDT5that are associated with immunity, protein transport, and energy metabolism. Across the four time-periods, respectively 12, 13, 16, and 10 associated genomic regions across 14 chromosomes were identified for TV. For the three EG classes, respectively 18, 15, and 14 associated genomic windows were identified for TV, respectively. Each time-period and EG class had uniquely enriched genes with identified specific biological functions, including regulation of the nervous system, metabolism and hormone production.ConclusionsTVis a heritable trait with substantial additive genetic variation and represents a promising indicator trait to select pigs for improved heat tolerance. Moderate GxE for TVexist, indicating potential re-ranking of selection candidates across EG. TVis a highly polygenic trait regulated by a complex interplay of physiological, cellular and behavioral mechanisms.
Inferring circRNA-drug sensitivity associations via dual hierarchical attention networks and multiple kernel fusion
Authors: Lu Shanghui , Liang Yong , Li Le , Liao Shuilin , Zou Yongfu , Yang Chengjun , Ouyang Dong 
Published: December 2023

AbstractIncreasing evidence has shown that the expression of circular RNAs (circRNAs) can affect the drug sensitivity of cells and significantly influence drug efficacy. Therefore, research into the relationships between circRNAs and drugs can be of great significance in increasing the comprehension of circRNAs function, as well as contributing to the discovery of new drugs and the repurposing of existing drugs. However, it is time-consuming and costly to validate the function of circRNA with traditional medical research methods. Therefore, the development of efficient and accurate computational models that can assist in discovering the potential interactions between circRNAs and drugs is urgently needed. In this study, a novel method is proposed, called DHANMKF , that aims to predict potential circRNA-drug sensitivity interactions for further biomedical screening and validation. Firstly, multimodal networks were constructed by DHANMKF using multiple sources of information on circRNAs and drugs. Secondly, comprehensive intra-type and inter-type node representations were learned using bi-typed multi-relational heterogeneous graphs, which are attention-based encoders utilizing a hierarchical process. Thirdly, the multi-kernel fusion method was used to fuse intra-type embedding and inter-type embedding. Finally, the Dual Laplacian Regularized Least Squares method (DLapRLS) was used to predict the potential circRNA-drug sensitivity associations using the combined kernel in circRNA and drug spaces. Compared with the other methods, DHANMKF obtained the highest AUC value on two datasets. Code is available at https://github.com/cuntjx/DHANMKF.
An extranodal Richter’s syndrome presenting with cardiac diffuse large B-cell lymphoma: a case report
Authors: Wang Hua , Yan Wei-hong , Sun Jun-jie , Dong Mei , Zhang Nan , Liu Tong , Song Nian-peng , Zhong Lin 
Published: December 2023

Abstract
Background
Richter’s syndrome (RS) defines the transformation of chronic lymphocytic leukemia into high-grade lymphoma, which usually involves lymph nodes and bone marrow. Extranodal involvement of the heart is an extremely rare condition. Patients with heart involvement tended to have a low response to chemotherapy and relative poor prognosis. The transformation process of RS is often insidious and nonspecific making it challenging to diagnose.

Case presentation
A 64-year-old woman wih a history of chronic lymphocytic leukemia (CLL) presented with intermittent chest pain and was diagnosed with non-ST-elevation myocardial infarction (NSTEMI). However, the contrast enhanced echocardiography revealed a large irregular mass, measuring about 75.4 mm × 37.5 mm, located on the lateral and posterior wall of the right ventricle. Biopsy of the cardiac mass and the results revealed diffuse large B-cell lymphoma.

Conclusions
We present a case of a 64-year-old woman with aggressive diffuse large B-cell lymphoma involving the heart. This case could provide some insights in the diagnosis of cardiac lymphoma.
Recruiting patients for falls prevention in the emergency department – worth the challenge
Authors: Stuckenschneider Tim , Schmidt Laura , Speckmann Elisa-Marie , Koschate Jessica , Zieschang Tania 
Published: December 2023

Abstract
Background
Severe falls escalate the risk of future falls and functional decline as indicated by recent global guidelines. To establish effective falls prevention, individuals at highest risk must be thoroughly studied and, therefore, successfully recruited.

Objective
Recruiting from an emergency department (ED) may mitigate common selection biases, such as overrepresentation of individuals with a higher social status and healthier lifestyle. However, this approach presents unique challenges due to ED-specific conditions. Hence, we present the successes and challenges of an ED-based recruitment for an observational study.

Methods
The SeFallED study targets older adults aged ≥60 years, who present to either of two hospitals in Oldenburg after a fall without subsequent admission. A study nurse addressed individuals in the EDs. Subsequently, potential participants were contacted by phone to arrange a home visit for obtaining written consent. Data of participants were compared with total admissions during the recruitment period to determine recruitment rate and compare patients’ characteristics.

Results
Over 1.500 individuals met the inclusion criteria. Of these, 288 participants were successfully recruited. Most patients presented to the ED outside of the study team’s working hours, and some opted not to participate (main reason: too unwell (40%)). Compared to working hours, a participant was recruited every 14 h. Comparing characteristics, a trend towards better health and younger age was observed.

Conclusion
ED-based recruitment offers the opportunity to include more diverse individuals in falls prevention. To achieve adequate sample sizes, flexibility in working days and hours of the research team are obligatory.

Trial registration
DRKS00025949.