bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Genetic Subtypes of Diffuse Large B-Cell Lymphoma for Outcome Prediction and Interpretation of FDG-PET treatment Response Monitoring
Authors: Ylstra Bauke , Mendeville Matias , Janssen Jurriaan , Vries G. Tjitske Los-de , Dijk Erik van , Richter Julia , Nijland Marcel , Roemer Margaretha , Stathi Phylicia , Hijmering Nathalie , Bladergroen Reno , Pelaz Diego , Diepstra Arjan , Eertink Corinne , Burggraaff Coreline , Kim Yongsoo , Lugtenburg Pieternella , Berg Anke van den , Tzankov Alexandar , Dirnhofer Stephan , Duhrsen Ulrich , Hüttmann Andreas , Klapper Wolfram , Zijlstra-Baalbergen Josée , de Jong Daphne 
Published: October 2023

Abstract
Next-generation sequencing (NGS)-based genetic subtyping and interim- and end-of-treatment 18fluorodeoxyglucose-positron emission tomography (i/eot-PET) have high potential for upfront and on-treatment risk assessment to guide personalized treatment of diffuse large B-cell lymphoma (DLBCL-NOS). We performed NGS genetic subtyping according to the Dana Farber Cancer Institute (DFCI) and LymphGen using biopsy samples in a combined cohort of DLBCL-NOS patients of the HOVON84 (n=208) and PETAL (n=204) clinical trials together with NGS data of 304 DFCI study samples. For all uniformly R-CHOP treated patients (n=592), the DFCI-C5, -C2, LymphGen-MCD and -A53 genetic subtypes showed significantly worse outcome independent of IPI. Adverse prognostic value of i/eot-PET positive status was confirmed for all subtypes. However, DFCI-C2 patients showed slow response to reach negative eot-PET status of only 67% versus rapid response of 81-88% for all other subtypes, implicating frequent primary refractory disease. Outcome for i/eot-PET negative patients remained significantly worse for DFCI-C5 in HOVON-84 (negative predictive value 81% versus 88% for C1-C4), which trend validated independently in both PETAL and SAKK38-07 trial patients, indicating high rates of relapse despite reaching complete metabolic response. These results show the added value of genetic subtyping for prognostic stratification and for the value of i/eot-PET for treatment response monitoring.
Are teams with grateful leaders more creative? A Tertius Iungens Perspective
Authors: Xu Feng , Yuan Yutong , Cai Wenhua , Zhang Dayong 
Published: October 2023

Abstract
The discrete affective traits of leaders and how they influence team creativity are still unresolved issues in current study. This study, which examines the intervention mechanism of a leader's trait gratitude to predict team creativity, contends that this trait will encourage team leaders to connect with talents, acting as a broker on social network, that is, displaying tertius iungens orientation, and subsequently promote team creativity. The empirical analysis based on the multi-source paired data of 105 working teams indicate that: First, leader tertius iungens orientation plays an mediating role between leader trait gratitude and team creativity; Second, perceived organizational support positively moderate the relationship between leader trait gratitude and tertius iungens orientation; Third, the leader trait gratitude indirectly affects team creativity through tertius iungens orientation, and this positive and indirect relationship is only significant when the perceived organizational support is high. The significance of the research findings in terms of theory and application is also covered in the paper.
Efficacy of Fish scale based Silver Nanoparticles (FS-AgNPs) against dengue vector, Aedes aegypti
Authors: Adnan Muhammad , Tahir Hafiz Muhammad , Ali Aamir , Summer Muhammad , Ismail Muhammad , Muzamil Ayesha , Zaidi Syeda Durr E Shahwar , Ijaz Fatima 
Published: October 2023

Abstract
The control of mosquitoes, vectors of various life-threatening pathogens using biologically synthesized nanoparticles is gaining popularity. Current study was aimed to evaluate the efficacy of fish scale based silver nanoparticles (FS-AgNPs) against a dengue vector, Aedes aegypti (L.). The extract of Nile tilapia fish (Orochromis niloticus) scales was used to synthesize Silver based Nanoparticles. Collagen in the FS-extract acted as a reducing and capping agent. FS-AgNPs were characterized by UV-Visible spectrophotometry and a diagnostic absorption peak was observed at 490nm. Fourier Transform Infrared Spectroscopy (FTIR) was used to confirm the presence of various functional groups in FS-AgNPs. Larvicidal potentials of different concentrations of crude fish scale extract (200–500 ppm) and FS-AgNPs (10–40 ppm) were assessed against laboratory strain and field populations from different localities of Lahore (i.e., Model Town, Misri Shah, Valencia, Sadar Cantt. and Walton). In case of FS-AgNPs, a significant concentration dependent mortality was observed (F5, 12=8.667; P < 0.05). Highest mortality was observed in Laboratory Strain (100%), however LC50 value was highest (17.57 ppm) against the larval population of Walton. Toxicity of nanoparticles on a non-target organism Oreochromis niloticus (Tilapia) was also assessed in water. No mortality or behavioural changes were recorded even after continuous exposure for 10 days. It is concluded that FS-AgNPs are effective to control dengue vector Ae. aegypti at young developmental stages during the aquatic phase of its life cycle and are safe for non-target organisms.
On the use of the healthy lifestyle index to investigate specific disease outcomes
Authors: Viallon Vivian , Freisling Heinz , Matta Komodo , Dahm Christina , Tjonneland Anne , Erisken Anne Kirstine , Kaaks Rudolf , Katzke Verena , Schulze Mattias , Masala Giovanna , Tagliabue Giovanna , Simeon Vittorio , Tumino Rosario , Milani Lorenzo , Derksen Jeroen W.G. , Schouw Yvonne T. van der , Nøst Therese Haugdahl , Borch Kristin Benjaminsen , Sandanger Torkjel , Quiros J. Ramon , Barranco Miguel Rodríguez , Bonet Catalina , Aizpurua-Atxega Amaia , Cirera Lluís , Guevara Marcela , Sundström Björn , Winkvist Anna , Heath Alicia K , Gunter Marc J. , Weiderpass Elisabete , Johansson Mattias , Ferrari Pietro , Naansen Østergaard 
Published: October 2023

Abstract

The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weighted according to their associations with disease outcomes. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the association between the standard and the outcome-specific HLIs and the risk of T2D, CVD, cancer, and all-cause premature mortality. Estimates of the hazard ratios (HRs), the Harrell’s C-index and the population attributable fractions (PAFs) were compared. For T2D, the HR for 1-SD increase of the standard and T2D-specific HLI were 0.66 (95% CI: 0.64, 0.67) and 0.43 (0.42, 0.44), respectively, and the C-index were 0.63 (0.62, 0.64) and 0.72 (0.72, 0.73). Similar, yet less pronounced differences in HR and C-index were observed for standard and outcome-specific estimates for cancer, CVD and all-cause mortality. PAF estimates for mortality before age 80 were 57% (55%, 58%) and 33% (32%, 34%) for standard and mortality-specific HLI, respectively. The use of outcome-specific HLI could improve the assessment of the role of lifestyle factors on disease outcomes, thus enhancing the definition of public health recommendations.
Suberin, the hallmark constituent of bark, identified in a 45-million-year-old monkeyhair tree from Geiseltal, Germany
Authors: Tahoun Mariam , Gee Carole T. , McCoy Victoria E. , Stoneman Michael , Raicu Valerica , Engeser Marianne , Müller Christa Elisabeth 
Published: October 2023

Abstract
Suberin, a complex biopolymer, forms a water and gas insoluble barrier that protects the inner tissues of plants. It is abundant in tree bark, particularly in the cork oak Quercus suber. Anatomically, fossil bark has been described since the Devonian. However, its distinctive constituent suberin has not yet been reported from the fossil record. Here we present unambiguous chemical evidence for intact suberin from the outer layer of a middle Eocene monkeyhair tree from Geiseltal, eastern Germany. High-performance liquid chromatography coupled to electrospray ionization mass spectrometry (HPLC-ESI-MS) was employed to detect constituents of suberin in the outer layer of the fossil monkeyhair tree, which confirms previous morphological interpretation of this tissue as bark, and chemically differentiates this layer from the two tissues of the inner layer. Notably, this is the first study with compelling chemical evidence for suberin in fossil bark. Fluorescence microspectroscopy additionally supported the presence of suberin. Fossilization conditions in the Eocene Geiseltal deposit were likely mild, with low moisture and temperatures, contributing to the remarkable preservation of bark and inner laticifer mats of the monkeyhair trees growing there 45 million years ago.
Central pulse wave velocity and augmentation index are repeatable and reproducible measures of arterial stiffness
Authors: Russell Sophie L. , Rahman Mushidur , Steward Charles J. , Harwood Amy E. , McGregor Gordon , Banerjee Prithwish , Okwose Nduka C. , Jakovljevic Djordje G. 
Published: October 2023

Abstract
Purpose: Arterial stiffness is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial stiffness. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx in healthy individuals.
Methods: Forty healthy participants (age 33±11 years, 17 females) underwent resting supine PWV and Alx assessments. Measurements were made in triplicate and repeated one week apart. Alx was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery by the tonometer - oscillometric method. Repeatability and reproducibility were assessed using intra-class correlation coefficient (ICC). Inter-operator reproducibility was performed on ten participants.
Results: The average values for week-to-week visits for PWV and Alx were 6.20±0.91 vs 6.13±0.91 ms-1 and 14.0±11.8 vs 16.3±12.2 %. For same-day measurements, both PWV and Alx showed excellent repeatability (PWV: ICC=0.96, 95% CI 0.92-0.98, p<0.01; and Alx: ICC=0.90 95% CI 0.84-0.94, p<0.01) and inter-operator reproducibility (PWV: ICC=0.98, 95% CI 0.93-1.00, p<0.01; and Alx: ICC=0.93 95% CI 0.69-0.98, p<0.01). Measurements were repeated one week apart and showed good reproducibility (PWV: ICC=0.77, 95% CI 0.61-0.87, p=<0.01; and Alx: ICC=0.73 95% CI 0.73-0.86, p<0.01).
Conclusion: PWV and Alx demonstrate excellent repeatability and good reproducibility. Considering these variables are non-invasive and easy-to-measure, arterial stiffness may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.
Identification and mapping of Individual Trees from Unmanned Aerial Vehicle Imagery Using an object oriented Convolutional Neural Network
Authors: Ameslek Oumaima , Zahir Hafida , Mitro Soukaina , Bachaoui El Mostafa 
Published: October 2023

Abstract

Precision agriculture (PA) is an agricultural management strategy founded on the observation, measurement and responding to inter/intra-field crop variability. It includes advances in data collection/analysis and management, along with the technological developments in Data storage and retrieval, accurate positioning, yield monitoring and remote sensing. The last provides unprecedented spatial, spectral, and temporal resolution, but can also provide detailed information about the vegetation’s height and various observations. Today, the success of new agricultural technologies has meant that many farming tasks have become automated, and scientists have carried out more studies and companies based on intelligent algorithms that automatically learn decision rules from data. The use of deep learning (DL) and particularly the development and application of some of its algorithms called convolutional neural networks (CNN) is considered a particular success. In the present work, we applied and tested the performance of a simple Convolutional Neural Network to automatically detect and map olive trees from a Phantom4 advanced drone imagery. The workflow involved the image acquisition and the orthomosaic generation with Pix4D software, beside the use of geographical information system and object-based image analyses. The application to a RGB ortho-mosaic of an olive grove, in the east region of Morocco, performed well achieving an overall accuracy of 95.16%.
A tunable blackbody polarized infrared source for the BBOP camera
Authors: Navick Xavier-François , Martignac Jérôme , Pöglitsch Albrecht , Revéret Vincent , Rodriguez Louis , Tollet Timothée , Visticot François 
Published: October 2023

Abstract
The B-BOP detector is composed of polarization sensitive bolometer arrays in the 70–350 µm spectral range with a goal sensitivity around one attoWatt/sqrt(Hz). A polarized infrared set-up is required to evaluate its performances. The source is based on blackbody-likes emitters whose total surface is tunable within a factor of 120 from 9 mm2 up to 1200 mm2 and whose temperature is tunable from 1 K to 40 K without disturbing the dilution cryostat and the working temperature of the matrix. The present paper describes the source, the rotating polarizer at low temperature, the modulation means, and the complete optical tube leading polarized infrared photons for characterizing detectors down to femtowatt level. Details of the design and realization are discussed.
Chemical, Chromatographic and Electron Microscopic Analysis of the Bubbles Emerging During Holmium:YAG Laser Lithotripsy of Cystine Stone
Authors: Kılınç Muzaffer Tansel , Özkent Mehmet Serkan , Göger Yunus Emre 
Published: October 2023

Abstract
The primary aim of the present in vitro study is to analyze the chemical content of the bubbles occurring during the fragmentation of cystine stone with high-power and low-power Ho:YAG laser. The secondary aim of our study is to discuss their clinical importance. Human renal calculi (calcium oxalate monohydrate (COM), cystine, and uric acid) were fragmanted with low-power and high-power Ho:YAG laser in separate experimental setups at room temprature, and it was observed whether the gas production during this time. After laser lithotripsy, a cloudy colored gas was obtained only fragmentation of cystine stone. Qualitative gas content analysed performed with Gas chromatography–mass spectrometry device. In addition, the fragments in the aqueous cystine calculi setup were dried and taken to the laboratory to be examined with scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and X-ray diffraction analysis. No gas production was observed after fragmentation in the COM and uric acid stone. Free cystine, sulfur, thiophene, and hydrogen sulfide gas were produced by low-power and high-power Ho:YAG laser lithotripsy of cystine stone. In SEM-EDX mapping analysis, free cystine molecule containing 42.8% sulfur (S), 21% oxygen (O), 14.9% carbon (C), 21% nitrogen (N) atom was detected in the cystine stone experimental setup. The evidence obtained that hydrogen sulfide emerges in the gaseous environment during Ho:YAG laser fragmentation of cystine stone requires caution against the risk of in vivo production and toxicity.
Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities
Authors: deGraffenried Linda , Mcclellan Bryan , Wilson Crystal , Brenner Andrew , Jolly Christopher 
Published: October 2023

Abstract

Flotillin-1 contributes to invasion and metastasis in triple negative breast cancer (TNBC) and is modified post-translationally through palmitoylation. Palmitoylation, the process of conjugating palmitoyl-CoA to proteins, plays an essential role in protein stability and trafficking. Thus far, there has not been any investigation into the role of flotillin-1 palmitoylation in the context of metastasis in vivo. To address the role of flotillin-1 palmitoylation in metastasis, MDA-MB-231 cells expressing palmitoylation defective flotillin-1 constructs were used as models. Compared to flotillin-1 WT expressing tumors, flotillin-1 palmitoylation defective displayed abrogated tumor progression and lung metastasis in vivo in both spontaneous and experimental models. Further mechanistic investigation led to the identification of zDHHC5 as the main palmitoyl acyltransferase responsible for palmitoylating endogenous flotillin-1. Modulation of flotillin-1 palmitoylation status through mutagenesis, zDHHC5 silencing, and 2-bromopalmitate inhibition all resulted in the proteasomal degradation of flotillin-1 protein. To assess if flotillin-1 palmitoylation can be inhibited for potential clinical relevance, we designed a competitive peptide fused to a cell penetrating peptide sequence, which displayed efficacy in blocking flotillin-1 palmitoylation in vitro without altering palmitoylation of other zDHHC5 substrates, highlighting its specificity. Additionally, TNBC xenograft tumor models expressing a doxycycline inducible flotillin-1 palmitoylation inhibiting peptide displayed attenuated tumor growth and lung metastasis. Collectively, these results reveal a novel palmitoylation dependent mechanism which is essential for the stability of flotillin-1 protein. More specifically, disruption of flotillin-1 palmitoylation through mutagenesis or competitive peptide promoted flotillin-1 protein degradation, subsequently impeding its tumor promoting and metastasis-inducing effects in TNBC tumor models.
The Effect of Iodine Nutrition during Pregnancy on Their Neonatal Physical Growth and Thyroid Function in Iodine Deficient Area
Authors: Li Xiaoman , Chen Chao , Huang Lijuan , Jiang Hui , Wang Xiao , Guo Runmin , Chen Yanting , Du Jinlin 
Published: October 2023

Abstract
Background: The impact of mild to moderate iodine deficiency is still controversial. We aimed to explore the effects of mild-to-moderate iodine deficiency during pregnancy on neonatal physical growth and TSH.
Methods: 2613 pregnant women and their infants were enrolled in this prospective cohort study. Spot urine and venous blood samples were collected to determine urinary iodine concentration (UIC) and thyroid-stimulating hormone (TSH). Heel blood samples of neonates were collected within 72 hours after birth to determine neonatal TSH.
Results: The median UIC was 116 (64, 190) μg/L and 63.9% of pregnant women had UIC < 150μg/L, indicating mild-to-moderate iodine deficiency. Lower birth weight and WFA Z-scoreswere found in neonates with maternal UIC ranged 100-149μg/L during pregnancy(both P < 0.05), and were associated with parity (0 or ≥ 1), delivery week (< 37wks or ≥ 37wks) and delivery way (all P < 0.05). 40.4% neonates had TSH ≥ 5.0mIU/L. Neonatal TSH increased by 0.28mIU/L per unit in neonates with nulliparous mother than multiparous, 1.12mIU/L higher in term neonates than preterm and 0.44mIU/L higher in neonates born via NVD than CS (all P < 0.05), respectively. The rate of neonatal TSH ≥ 5.0mIU/L was 1.103 folds positively associated with Maternal TSH and 1.178 times higher related to parity equals 0, 2.485 times higher in term neonates than preterm and 1.444 times higher in neonates born via NVD than CS (all P<0.05).
Conclusions: The iodine nutrition in pregnant women in Shunde was mild-to-moderate deficient. Lower birth weight and WFA Z-scores in neonates were related to maternal UIC within 100-149μg/L.BMI of pregnant women, parity, neonatal gender, delivery week and way affected neonatal birth weight and WFA Z-scores. High maternal TSH led to high neonatal TSH. Maternal age, parity, delivery week and way had effects on neonatal TSH and neonatal TSH ≥ 5.0mIU/L.
Habitat associations of day-flying Lepidoptera and their foodplants within nature reserves in Bedfordshire, UK
Authors: Ashe-Jepson Esme , Anderson Juliet , Hitchcock Gwen E. , Wallis Sky , Wingader Keira , Bladon Andrew J. , Turner Edgar C. 
Published: October 2023

Abstract
Species often associate with specific habitat characteristics, resulting in patchy distributions, whereby they only occupy a proportion of available habitat. Understanding which characteristics species associate with is a valuable tool for informing conservation management. We investigated the habitat associations of eleven species of day-flying Lepidoptera larvae and their foodplants within calcareous grassland reserves in Bedfordshire, UK, across two scales relevant to land managers and target species: the reserve (cardinal aspect, vegetation type) and foodplant patch scale (foodplant height and density). We investigated whether ecological traits (habitat specialism and overwintering life stage) influenced the strength of associations. At the reserve scale, we found variation in habitat associations across species, with species that overwinter at non-adult life stages having more restricted associations, indicating that they may be more vulnerable to environmental change. Associations were generally stronger with vegetation type than aspect, which can be manipulated more easily by land managers. Seven species had similar habitat associations to their foodplants, implying that management to benefit foodplants will also benefit larvae. However, the remaining four species had different habitat associations to their foodplants, and may require alternative management approaches. At the foodplant patch scale, four species were associated with foodplant characteristics, which could be used to inform effective fine-scale management.
Green Building Materials: Mechanical Strength Characteristics of Banana Fibered Concrete with PSC and Nano-silica for Enhanced Performance
Authors: Rakshitha Teki Jaya , Adiseshu S. 
Published: October 2023

Abstract
This paper navigates into the fusion of natural fibers and Nano- materials that holds the key to usher towards the greener concrete. Banana fiber (BF) is used as an addition to the cement in concrete where it is an eco-friendly material having good ductile properties and it also strengthens the inherent weakness of the concrete. In this research the fibrous concrete was intended to evaluate mechanical and few durability properties of concrete grades for M25 and M35.The fibrous concrete of M25BF5& M35BF5and M25BF5 NS1.5 & M35BF5NS1.5 compared with conventional concrete with the use of 100% M-sand (also known as Robo sand) replacement to river sand as fine aggregate, Master Glenium SKY-8321, Nano-Silica (NS) and Portland Slag Cement (PSC) in combination with 5% optimized banana fiber (BF5), length of the fiber of 2.5mm and 1.5% Nano-silica (NS1.5) is used to achieve superior mechanical properties. The mechanical properties of fibrous concrete tests were performed such as compressive, split tensile strength test, modulus of rupture and Pull-out test as per Indian Standards at 3,7 &28 days. As per the probe the banana fibered concrete yielded virtuous outcome in compressive strength which also resulted in good tensile properties of concrete at all characteristic parameters for sustainability.