bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmentally Friendly Livestock Waste Management in High-Population Areas in Karang Ploso Malang Regency East Java
Authors: Arwani Muhammad , Hakim Abdul , Budiarto Agus , Ciptadi Gatot , Oktanella Yudit 
Published: November 2023

Purpose: This abstract explores the need for integrated development in the agricultural and livestock sectors of Ngenep Village, Karangploso, Malang Regency, focusing on utilizing livestock waste effectively.
Method: The study details the steps to develop a system for producing organic fertilizer and animal feed from agricultural and livestock waste. It highlights the successful implementation within the "Langgeng Mulya" dairy cattle farming community, emphasizing the utilization of waste for organic fertilizer in chili and tomato cultivation.
Practical Applications: The research findings showcase the positive response of local farmers to the utilization of livestock waste, addressing the scarcity of organic fertilizer, particularly for tomato and chili growers. This sustainable approach fosters self-sufficiency and offers insights into waste-to-resource strategies.
Conclusion: This study underscores the importance of integrating the agricultural and livestock sectors for sustainable waste management and resource utilization. It provides valuable lessons for enhancing the efficiency of rural development programs.
Pemberdayaan Keterampilan Warga Binaan dalam Usaha Peningkatan Efikasi diri di Lapas Pemuda Kelas IIA Tangerang
Authors: Hendra Hendra , Angreni Tri , Hanitha Vivin , Oktari Yunia , Yanti Lia Dama , Novianti Rini 
Published: November 2023

Peningkatan Keterampilan warga binaan pada Lembaga permasyarakatan Kelas IIA Tangerang, saat ini banyak mengikuti program latihan untuk menambah keahlian softskill melalui pemberdayaan program efikasi diri. Tujuan dari pembinaan adalah mendampingi narapidana agar siap diterima saat masa tahanan usai dan membekali mereka dalam hal keterampilan dan wirausaha, siap secara mental dan fisik untuk kembali ke masyarakat. Manfaat pembinaan ini sungguh besar dan banyak dirasakan oleh para warga binaan untuk lebih siap berkontribusi kelak . Ilmu dari pembinaan yang didapat bisa dipakai untuk mencari peluang atau bahkan membuat usaha baru dan diharapkan bisa menjadi pribadi yang lebih baik. Pengabdian ini dilakukan oleh tim dosen Universitas Buddhi Dharma melalui metode survey, pelatihan dan evaluasi. Pelatihan berjalan lancar dan Semangat para warga binaan dalam mengikuti pelatihan sangat aktif dilihat dari banyaknya peserta yang aktif bertanya pada sesi penjelasan. Diharapkan kegiatan ini bisa berlangsung berkelanjutan.
DELIGNIFICATION PRETREATMENT OF ACANTHOSPERMUM HISPIDUM BIOMASS FOR BIOETHANOL PRODUCTION
Authors: Ahmad M. A. , Tambuwal A. D. , Sokoto A. M. , Sanda A. 
Published: November 2023

Bioethanol from lignocellulosic biomass is environmentally friendly and a renewable source of energy. This study used delignification as a pretreatment process to obtain the optimum conditions for reducing sugar production. The selected delignification parameters, including temperature (oc), time(hours) sodium chlorite concentration (g/dm3) and Volume of acetic acid (cm3). The Optimum conditions for delignification were: 70oc, 6 hr at -0.1 g/ dm3 sodium chlorite concentration and acid-3 cm3 of acetic. The R2 value obtained from the correlation between reducing sugar concentration and time was R2 =0.796 The maximum bioethanol concentration was at 66h and the bioethanol productivity was 0.0304 g/L/h. The result obtain pointed that, the Acanthospermum hispidum can be used for both economic and environmental footprint studies and real world application.
Analisis Kesesuaian Wisata Bahari Di Pulau Semujur Kabupaten Bangka Tengah
Authors: Fauzi Ikhwan , Syari Indra Ambalika , Utami Eva 
Published: November 2023

Kajian tentang lokasi wisata bahari di Kawasan Pulau Semujur merupakan permasalahan yang perlu dikaji guna meningkatkan kepuasan dan keselamatan masyarakat yang melakukan kegiatan wisata. Pulau Semujur termasuk kawasan konservasi perairan yang dilindungi dan dikelola untuk mewujudkan pengelolaan sumber daya ikan dan lingkungan secara berkelanjutan. Penelitian ini bertujuan untuk menganalisis indeks kesesuaian wisata rekreasi pantai dan menganalisis indeks kesesuaian wisata snorkeling di Pulau Semujur serta diharapkan dapat digunakan sebagai referensi bagi pemangku kepentingan yang terlibat dalam pengembangan wisata di Pulau Semujur Kabupaten Bangka Tengah. Pengambilan sampel dilakukan pada bulan Maret 2021 bertempat di Pantai Semujur Kabupaten Bangka Tengah. Metode penelitian yang digunakan yakni Purposive Sampling. Analisis data didasarkan pada matriks indeks kesesuaian wisata (IKW). Hasil studi kesesuaian wisata rekreasi pantai dan wisata snorkeling di Pulau Semujur menunjukan nilai indeks kesesuaian wisata rekreasi pantai di masing-masing stasiun pengamatan mendapatkan nilai sebesar 83% (sangat sesuai). Nilai indeks kesesuaian wisata snorkeling di masing-masing stasiun pengamatan mendapatkan nilai sebesar 57,75% (sesuai).
Karakteristik Morfologi Dan Sebaran Lamun Halophila spinulosa (R.Br.) Aschers. Di Kepulauan Bangka Belitung, Indonesia
Authors: Adi Wahyu , Muftiadi M. Rizza , Henri Henri , Pamungkas Aditya , Supratman Okto 
Published: November 2023

Halophila spinulosa (R. Br.) Aschers merupakan salah satu jenis lamun ditemukan di Indonesia dengan sebarannya terbatas. Salah satu daerah yang ditemukan jenis lamun Halophila spinulosa yaitu di Kepulauan Bangka Belitung. Meskipun ditemukan di Kepulauan Bangka Belitung akan tetapi informasi jenis lamun ini sangat terbatas. Adapun tujuan penelitian yaitu mengidentifikasi karakter morfologi, mengetahui jenis lamun yang berasosiasi dengan lamun Halophila spinulosa dan menyajikan peta sebaran Halophila spinulosa di Kepulauan Bangka Belitung. Metode penelitian untuk karakter morfologi lamun berdasarkan data lapangan berupa foto, kemudian dibandingkan dengan sumber identifikasi dari buku dan jurnal penelitian. Peta sebaran lamun ditentukan berdasarkan penelusuran pustaka dari tahun 2015 s.d 2022 kemudian dibuat peta dengan menggunakan dengan software Arcmap 10.8. Hasil penelitian karakter morfologi spesies Halophila spinulosa dapat dilihat dari bentuk akar, rhizoma, daun, bunga dan buah. Bentuk akar jenis ini yaitu perakaran yang tidak bercabang (simple root) dan setiap buku (node) pada rhizoma memiliki satu akar. Bentuk daun majemuk yang berbentuk bulat panjang yang berpasangan, dengan posisi berlawanan, terletak pada satu bidang, tersusun miring disekitar tangkai dan memiliki ujung daun bergerigi (serrated). Sebaran lamun lamun Halophila spinulosa di Kepulauan Bangka Belitung tersebar di daerah Kabupaten Bangka Tengah, Kabupaten Bangka Selatan dan Kabupaten Belitung. Spesies Halophila spinulosa sering ditemukan bercampur (berasosiasi) dengan jenis lamun Halodule uninervis dan Oceana serrulata.
Genetic modification – benefits and risks for New Zealand grassland production systems
Authors: Caradus John 
Published: November 2023

Fundamentally plant breeding is about expanding and exploiting the genetic potential of plants (Stoskopf et al. 2019). Over time this has included amongst others phenotypic selection, mutagenesis, genetic modification (GM) and now gene editing (Bowerman et al. 2023). In many crop species genetic modification has been a valuable option for delivering improved economic and environmental outcomes. However, while genetic modification has been extensively used in crops for 25 years it has rarely been a technology used to advance trait expression in forage and grassland species. Worldwide, GM technologies have been adopted at a faster rate than any other recent crop technology (Raman 2017; Scheitrum et al. 2020). Despite the large government investment into GM technologies for use in grass and forage plants it has not used outside of containment in New Zealand (Caradus 2008).
The aim here is to review why New Zealand has been so reluctant to use GM technologies as another means of providing solutions for the pastoral sector. Traits manipulated using a range of genetic modification techniques that might have application and benefit in grassland systems will be reviewed, and regulatory concerns that need to be considered when adopting GM forage and pasture plants will be discussed. Interestingly, 70 to 90% of GM crop production globally is used for animal feed (Flachowsky et al. 2012; Ritchie and Roser 2021). So if animals across the world, including those in USA, China and Europe are being fed GM crops (Baulcombe et al. 2014) why would New Zealand be concerned about using GM pasture plants? Although over a decade old, a useful summary of views from a variety of stakeholders is provided by the New Zealand Institute of Agricultural & Horticultural Science (AgScience 2010).
Biomechanical evaluation of a novel anterior transpedicular screw-plate system for anterior cervical corpectomy and fusion (ACCF): a finite element analysis
Authors: Huang Shengbin , Ling Qinjie , Lin Xinxin , Qin Hao , Luo Xiang , Huang Wenhua 
Published: November 2023

Background and objective: Cervical fusion with vertebral body screw (VBS)-plate systems frequently results in limited biomechanical stability. To address this issue, anterior transpedicular screw (ATPS) fixation has been developed and applied preliminarily to multilevel spinal fusion, osteoporosis, and three-column injury of the cervical spine. This study aimed to compare the biomechanical differences between unilateral ATPS (UATPS), bilateral ATPS (BATPS), and VBS fixation using finite element analysis.Materials and methods: A C6 corpectomy model was performed and a titanium mesh cage (TMC) and bone were implanted, followed by implantation of a novel ATPS-plate system into C5 and C7 to simulate internal fixation with UATPS, BATPS, and VBS. Internal fixation with UATPS comprises ipsilateral transpedicular screw-contralateral vertebral body screw (ITPS-CVBS) and cross transpedicular screw-vertebral body screw (CTPS-VBS) fixations. Mobility, the maximal von Mises stress on TMC, the stress distribution and maximal von Mises stress on the screws, and the maximum displacement of the screw were compared between the four groups.Results: Compared with the original model, each group had a reduced range of motion (ROM) under six loads. After ACCF, the stress was predominantly concentrated at two-thirds of the length from the tail of the screw, and it was higher on ATPS than on VBS. The stress of the ATPS from the cranial part was higher than that of the caudal part. The similar effect happened on VBS. The screw stress cloud maps did not show any red areas reflective of a concentration of the stress on VBS. Compared with VBS, ATPS can bear a greater stress from cervical spine movements, thus reducing the stress on TMC. The maximal von Mises stress was the lowest with bilateral transpedicular TMC and increased with cross ATPS and with ipsilateral ATPS. ITPS-CVBS, CTPS-VBS, and BATPS exhibited a reduction of 2.3%–22.1%, 11.9%–2.7%, and 37.9%–64.1% in the maximum displacement of screws, respectively, compared with that of VBS.Conclusion: In FEA, the comprehensive stability ranked highest for BATPS, followed by CTPS-VBS and ITPS-CVBS, with VBS demonstrating the lowest stability. Notably, utilizing ATPS for fixation has the potential to reduce the occurrence of internal fixation device loosening after ACCF when compared to VBS.
Case report: A frameshift mutation in CLCN2-related leukoencephalopathy and retinopathy
Authors: Cheng Yizhe , Liu Xinyu , Sun Limei , Ding Xiaoyan 
Published: November 2023

Background: Leukoencephalopathy and visual impairment have been linked to loss-of-function mutations in the CLCN2 gene (MIM #600570). However, the ocular features caused by the CLCN2 mutations remain poorly understood and seldom reported. This study aims to present a novel mutation and characterize the ocular phenotype in a Chinese female diagnosed with CLCN2-related leukoencephalopathy (CC2L), also known as leukoencephalopathy with ataxia (LKPAT; MIM #615651).Case presentation: A 20-year-old Chinese female presented with bilateral blurred vision persisting for 2 years, which had worsened over the past 6 months. Ophthalmologic examination revealed bilateral post-capsular cataracts, macular retinal atrophy, and peripheral retinal pigmentation. Swept-source optical coherence tomography (SS-OCT) showed bilateral choroidal capillary atrophy, loss of the outer retinal layer, and a novel noteworthy sign of vacuole-like vitreoretinopathy. Cranial magnetic resonance imaging confirmed leukoencephalopathy. Genetic testing identified a novel homozygous pathogenic c.1382_1386del (p.P461Lfs*13) mutation in exon 13 of the CLCN2 gene.Conclusion: This case report expands the knowledge of CLCN2 mutations and their associated ocular manifestations in patients with CC2L. The identified ophthalmic features may serve as crucial indicators for early diagnosis in individuals with CC2L, especially in the absence of evident neurological symptoms.
A new method for predicting the maximum wave height of ship-generated onshore slopes in restricted channel
Authors: Huang Wei , Li Shouqian , Lu Yongjun , Zhang Rui , Wang Huai 
Published: November 2023

The ship-generated wave causes erosive damage to the slopes of inland waterways and confined waters such as the coastal zone. This critical issue is essentially associated with the navigational safety and sustainable development of coastlines, so it is vital to predicting the maximum wave height of the ship-generated wave (Hm) in the coastline of confined waters. The prediction equations of prior research works are mostly based on measured data and multiple regression analysis; however, this paper aims to propose a novel methodology to predict the maximum wave height of ship-generated waves in confined waters. The maximum wave height caused by a self-propelled ship under various conditions with confined water is measured by employing a water flume. Furthermore, the relationships of functions in the prediction model equation are appropriately derived by dimensional analysis, and the prediction equation model is then solved via the particle swarm optimization algorithm (PSOA). The experimental results reveal that the maximum wave height of the ship-generated wave is seriously affected by the water depth of the channel (hc), the navigation speed of the ship (Vc), and the distance from the forecast point to the navigation line of the ship (Sc). In addition, the maximum wave height grows and then lessens, which touches its peak point in the region close to Frh = 1. The dimensionless analysis indicates that the large wave height of the ship-generated wave can be expressed as a function of the channel depth (hc), ship speed (Vc), and the distance from the measurement point to the ship’s navigation line (Sc) as; HmSc=1Frh2f(gScVc 2). Subsequently, the specific prediction equation is determined by a regression model according to the measured data under various working conditions. By adopting the model expression equation, namely, HmFrh2Sc=k1(gScVc 2)k2, the coefficients k1 and k2 are evaluated via the PSOA, and the relationship between the water depth of the channel and the coefficients is suitably outlined to obtain the maximum wave height prediction model equations for ship-generated waves.
Quality of life, socioeconomic and psychological concerns in parents of children with tuberous sclerosis complex, STXBP1 and SYNGAP1 encephalopathies: a mixed method study
Authors: Salcedo-Perez-Juana María , Palacios-Ceña Domingo , San-Martín-Gómez Ana , Aledo-Serrano Ángel , Florencio Lidiane Lima 
Published: November 2023

BackgroundDevelopmental and Epileptic Encephalopathies (DEEs) occur in childhood and are associated with severe epileptic seizures and neurological impairment. The aim of this study was to combine quantitative and qualitative methodologies to comprehensively describe factors related to quality of life, impact on the family and psychosocial factors in parents of children with TSC, STXBP1 and SYNGAP1 variants.MethodsA convergent parallel mixed design including parents of children with DEE. In the cross-sectional study, 20 parents (10STXBP1, five SYNGAP1, five TSC) were given questionnaires on quality of life, impact on the family and psychological factors. In the descriptive qualitative study, in-depth interviews were conducted with 18 parents (nine STXBP1, five TSC, four SYNGAP1) using a semi-structured questionnaire. A thematic analysis was carried out. The results of the two studies were combined by showing similarities and differences through tables, figures, accounts, and joint displays.ResultsIn terms of quality of life, the integrated results were consistent in highlighting the importance of family interaction, although in the qualitative section the influence of the relationship between the children's siblings, the relationship with health professionals and the difficulties in obtaining public aid were highlighted. In terms of impact, the integrated results show that the illness has a significant impact on the family; the financial burden is highlighted, and the experience of the illness is discussed in depth. Finally, the psychological aspects, symptoms such as anxiety, stress and strain, were consistent. Most of the participants reported sleep disturbance, as identified in the questionnaire, although not mentioned in the interviews.ConclusionsThe combined results of the mixed method provide an in-depth analysis of the impact of DEEs on parents of children with STXBP1, SYNGAP1 and TSC.
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
Authors: Yang Hui-Wen , Lan Yan , Li An , Wu Han , Song Zi-Wei , Wan Ai-Ling , Wang Yue , Li Shi-Bao , Ji Shuai , Wang Zhong-Cheng , Wu Xin-Yu , Lan Ting 
Published: November 2023

Background: Ovarian cancer (OC) is the second most common gynecological malignancy and has a high mortality rate. The current chemotherapeutic drugs have the disadvantages of drug resistance and side effects. Myricetin, a kind of natural compound, has the advantages of easy extraction, low price, and fewer side effects. Multiple studies have demonstrated the anti-cancer properties of myricetin. However, its impact on OC is still unknown and needs further investigation. Therefore, this study aimed to elucidate the mechanism by which myricetin suppresses transforming growth factor-β (TGF-β) -induced epithelial-to-mesenchymal transition (EMT) in OC through in vivo and in vitro experiments.Methods:In vitro experiments were conducted to evaluate the effects of myricetin on cell proliferation and apoptosis using CCK8 assay, plate clonal formation assay, and flow cytometry. Western blot was employed to evaluate the expression levels of caspase-3, PARP, and the MAPK/ERK and PI3K/AKT signaling pathways. Wound healing, transwell, western blot and immunofluorescence assay were used to detect TGF-β-induced cell migration, invasion, EMT and the levels of Smad3, MAPK/ERK, PI3K/AKT signaling pathways. Additionally, a mouse xenograft model was established to verify the effects of myricetin on OC in vivo.Results: Myricetin inhibited OC proliferation through MAPK/ERK and PI3K/AKT signaling pathways. Flow cytometry and western blot analyses demonstrated that myricetin promoted apoptosis by increasing the expression of cleaved-PARP and cleaved-caspase-3 and the ratio of Bax/Bcl-2 in OC. Furthermore, myricetin suppressed the TGF-β-induced migration and invasion by transwell and wound healing assays. Mechanistically, western blot indicated that myricetin reversed TGF-β-induced metastasis through Smad3, MAPK/ERK and PI3K/AKT signaling pathway. In vivo, myricetin significantly repressed OC progression and liver and lung metastasis.Conclusion: Myricetin exhibited inhibitory effects on OC progression and metastasis both in vivo and in vitro. And it also reversed TGF-β-induced EMT through the classical and non-classical Smad signaling pathways.
Design and fabrication of cryogenic multiplexing control chip
Authors: Huang Rutian , Shi Yunfan , Geng Xiao , Yang Liangliang , Liu Jianshe , Chen Wei 
Published: November 2023

This paper presents a design and fabrication process of a cryogenic multiplexing control chip (MCC) for superconducting quantum computers. The working temperature of MCC can be 10 ∼ 30 mK, because it could be integrated with quantum processor in the same package. With a multiplexing ratio of 1:4 and designed working frequency 4–8 GHz, the MCC is a non-reciprocity device which consisted of bandpass filters and isolators, which are based on tunable inductor bridges (TIB). The MCC chip size is 6 × 6 mm2 and includes λ/2 coplanar waveguides resonators, superconducting quantum interference device arrays, capacitors, low pass filters, baluns and bias lines. Adopting self-aligned process of Josephson junctions, the fabrication of MCC constitutes four lithography masks. The modular design of MCC could facilitate the development of large-scale superconducting quantum computers.
Modeling the predictive role of music teachers’ job commitment and optimism in their sense of self-efficacy
Authors: Du Yadian 
Published: November 2023

IntroductionTeachers’ psychological factors have been argued to influence various aspects of music education. However, scant research has explored the psycho-affective aspects of music teachers’ work. To solve this shortage of research, this study examined the predictive role of Chinese music teachers’ job commitment and academic optimism in their self-efficacy.MethodsTo this end, 340 music teachers from four universities in Henan Province completed an online survey including three questionnaires.ResultsThe results of structural equation modeling (SEM) and regression analysis demonstrated that music teachers’ self-efficacy could be positively and significantly predicted by their optimism and job commitment.DiscussionThe study provided implications for music education to pay further attention to the psychology of teaching in this field. Finally, directions for further research are presented to scholars, who are interested in the psycho-emotional side of music education.
Effects of a death education based on narrative pedagogy in a palliative care course among Chinese nursing students
Authors: Zhu Yuanyuan , Bai Yamei , Wang Aihong , Liu Yuexian , Gao Qinyi , Zeng Zhi 
Published: November 2023

BackgroundDeath education has been confirmed to be an effective method to enhance nursing students’ attitudes and coping abilities toward death. However, integrated Narrative Pedagogy into the death education to explore educational effectiveness is still limited. The study aimed to evaluate the effects of a death education based on Narrative Pedagogy in a palliative care course on the attitude toward death, coping with death, and attitude toward caring for the dying among undergraduate nursing students in China.MethodsThe study was designed as a pre-post intervention study with a quasi-experimental design. All the participants received 6 class hours of death education which was designed in a palliative care course. The death education includes preparation, presentation, discussion, reflection, and practice of the narrative materials. Death Attitude Profile-Revised (DAP-R), Coping with Death Scale (CDS), and Frommelt Attitude Toward Care of the Dying-Form B (FATCOD-Form B) were used to measure outcomes.ResultsSixty undergraduate nursing students who consented. There were statistically significant increases in the mean score of neutral acceptance and approach acceptance in the DAP-R, CDS, and FATCOD-Form B before and after the intervention.ConclusionThis death education integrated Narrative Pedagogy which indicated to improve attitude toward death, competence to cope with death, and attitude toward the care of dying patients. The findings assist teachers in understanding the importance and urgency of death education, as well as providing a favorable approach to death education. However, the long-term effectiveness still needs to study in further.