bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological and mechanical characterization of a novel porous silicon membrane used in a lung-on-a-chip system
Authors: Genc Sahra , Thompson Sally , Hill Owen , Gislason Leif , Rodriguez Dakota , Showme Farjana , Motler Alex , Schreiner Sarah M. , Gestos Adrian , Ferguson Virginia L. , Jessing Jeff 
Published: October 2023

AbstractIn the last decade, organ-on-a-chip technology has been researched as an alternative to animal and cell culture models (Buhidma et al. in NPJ Parkinson’s Dis, 2020; Pearce et al. in Eur Cells Mater 13:1–10, 2007; Huh et al. in Nat Protoc 8:2135–2157, 2013). While extensive research has focused on the biological functions of these chips, there has been limited exploration of functional materials that can accurately replicate the biological environment. Our group concentrated on a lung-on-a-chip featuring a newly fabricated porous silicon bio-membrane. This bio-membrane mimics the interstitial space found between epithelial and endothelial cells in vivo, with a thickness of approximately 1 μm (Ingber in Cell 164:1105–1109, 2016). This study aims to establish a fabrication method for producing a thin, uniform porous silicon membrane with a predictable reduced modulus. We conducted mechanical and morphological characterization using scanning electron microscopy and nanoindentation. A small, parametric study was conducted to determine the reduced modulus of the porous silicon and how it may relate to the morphological features of the membrane. We compare our results to other works.
Graphical Abstract
Founder of endovascular neurosurgery Fyodor Andreevich Serbinenko (1928–2002). For the 95<sup>th</sup> anniversary of birth
Authors: Likhterman L. B. 
Published: October 2023

The author describes the life’s journey of Fyodor Andreevich Serbinenko, the founder of endovascular surgery, creator of a new chapter in the teaching on cerebral blood flow, and shares memories of friendship with this great scientist and beautiful person.F.A. Serbinenko had developed a brand‑new approach to treatment of cerebral vascular pathologies, namely, low‑trauma intravascular reconstructive interventions, as well as a complex of original endovascular operations for severe vascular pathologies, opened the first in the world department of endovascular surgery in Moscow, became the founder of the Russian school of endovascular surgeons.The principles and techniques of intravascular interventions developed by F.A. Serbinenko has been continuously developed and improved by his disciples and followers and are widely used in current clinical practice.
Results of using intraoperative ultrasound in surgery of neurodegenerative disorders of the lumbar spine
Authors: Aslanukov M. N. , Vasilyev S. A. , Levin R. S. , Oshchepkov S. K. 
Published: October 2023

Aim. To evaluate the results of intraoperative ultrasound examination (IOUS) in surgery of degenerative diseases of the lumbar spine.Materials and methods. To evaluate the results of the use of IOUS in the surgery of degenerative diseases of the lumbar spine, an analysis of prospective examination data of 147 patients operated on for degenerative diseases of the lumbar spine in the neurosurgical department of the B.V. Petrovsky National Research Center of Surgery from 2014 to 2018. To study the accuracy of the ultrasound method for determining the level of surgical access and assessing the degree of radiation load reduction, to study the quality of ultrasound imaging of the structures of the spinal canal, a descriptive study was conducted that included 100 patients (a group of method descriptions). To determine the effectiveness of the use of IOUS, a randomized controlled trial was conducted based on a statistical comparison of the results of surgical treatment of 2 similar parallel groups of patients (control and experimental) consisting of 47 patients each, who differed only in the use of IOUS. Patients of the control group were selected from the method description group. The control and experimental groups of patients were compared according to the following criteria: the duration of surgery, the volume of intraoperative blood loss, the duration of hospitalization, the degree of root pain after surgery, the level of quality of life after surgery, the number of recurrences of herniated disc. For IOUS, we used BK Medical Pro Focus 2202 and BK Medical Flex Focus 400 ultrasound machines with neurosurgical sensors Craniotomy 8862 and Burr-Hole 8863. We performed IOUS before flavotomy, after flavotomy and after decompression of nerve structures.Results. The method of determining the level of surgical access using IOUS has a high accuracy (100 %) and allows you not to use radiography and reduce the radiation load (on average by 0.02 mSv per patient). IOUS allows to adequately visualize the structures of the spinal canal in patients with degenerative pathology of the lumbar spine: the sensitivity of the method before flavotomy is 93 %, after flavotomy – 97 %, and after decompression of nerve structures – 100 %. Due to the high sensitivity of the IOUS method, it allows optimizing surgical access, controlling the radicality of decompression of nerve structures, documenting the fact of their decompression. The use of IOUS in patients with degenerative diseases of the lumbar spine can improve the results of surgical treatment by reducing the number of recurrences of disc herniation, reducing the degree of radicular pain after surgery, reducing the duration of surgery and the volume of intraoperative blood loss.Conclusion. IOUS is a simple, harmless and widely available method of intraoperative imaging, which allows to improve the results of surgical treatment of patients with degenerative pathology of the lumbar spine.
Traduzir De re aedificatoria de Alberti
Authors: Caye Pierre , Ribeiro Peixoto Elane 
Published: October 2023

Este artigo é um relato feito por Pierre Caye sobre a tradução do De re aedificatoria de Leon Battista Alberti do latim para o francês realizado por ele em parceria com Françoise Choay. A tradução, intitulada L’Art d’édifier, foi publicada em 2004 pela Maison du Seuil. O texto a seguir rememora a rotina que envolveu os tradutores durante os 15 anos dispensados no trabalho e, nos quais, encontros semanais eram realizados para a comparação dos mesmos trechos traduzidos que, submetidos ao escrutínio, ofereciam as bases para um resultado consensual. Durante os anos em que esse trabalho foi realizado , uma rede de colaboração foi se construindo com a participação de especialistas em Leon Battista Alberti, consolidando parcerias perenes. O artigo apresenta uma reflexão sobre a tradução, caminhos metodológicos possíveis e aproxima o trabalho do tradutor a um canteiro de obras, à semelhança do discurso albertiano.
Male sex ratio of red tilapia Oreochromis sp. after soaking in different concentrations of coconut milk at larvae stadia
Authors: Maulana Fajar , Sudrajat Agus Oman , Permana Andre , Mulyani Lina , Arfah Harton 
Published: October 2023

Tilapia has sexual dimorphism, based on the size and growth. Male tilapia has a faster growth rate than female tilapia. Masculinization can be carried out to produce monosexual tilapia seeds to accelerate fish growth. As the use of the 17α-methyltestosterone synthetic hormone for masculinization activities has been limited, natural ingredients are required as a substitute, namely coconut milk. This study aimed to determine the effect of different coconut milk concentrations as a phytosteroid material for the masculinization of red tilapia by immersing the larvae to the material. Tilapia fish larvae were immersed in coconut milk for 12 hours and then reared for 60 days at 100 larvae for each rearing container. There were four different treatments, namely control treatment without coconut milk immersion, S3 (3 ml/L coconut milk), S5 (5 ml/L coconut milk), and S7 (7 ml/L coconut milk). The results showed that the 7 ml/L coconut milk treatment increased the male sex ratio and specific growth rate and reduced the feed conversion ratio without a negative impact on the survival rate of red tilapia fry. In this study, the 7 ml/L coconut milk treatment was the best treatment, which produced a male sex ratio of 67.78 ± 4.16%.

Keywords: coconut milk, masculinization, monosex, phytosteroids, tilapia

ABSTRAK

Ikan nila memiliki dimorfisme seksual yang dapat dilihat dari ukuran dan pertumbuhannya. Ikan nila jantan memiliki laju pertumbuhan yang lebih cepat ketimbang ikan nila betina. Maskulinisasi dapat dilakukan untuk menghasilkan benih ikan nila monoseks dengan tujuan mempercepat pertumbuhannya. Penggunaan hormon sintetik 17α-methyltestosteron sudah dibatasi penggunaannya sehingga diperlukan bahan alami pengganti salah satunya santan kelapa untuk kegiatan maskulinisasi. Penelitian ini bertujuan mengevaluasi pengaruh perendaman santan kelapa sebagai fitosteroid untuk maskulinisasi ikan nila merah melalui perendaman larva dengan konsentrasi berbeda. Larva ikan nila direndam santan kelapa selama 12 jam dan selanjutnya dipelihara selama 60 hari dengan kepadatan 100 ekor untuk setiap wadah pemeliharaan. Terdapat empat perlakuan berbeda, kontrol tanpa perendaman santan, S3 (Santan 3 ml/L air), S5 (Santan 5 ml/L air) dan S7 (Santan 7 ml/L air). Hasil penelitian menunjukan perlakuan perendaman santan kelapa 7 ml/L dapat meningkatkan nisbah kelamin jantan dan laju pertumbuhan spesifik, serta menurunkan rasio konversi pakan dan tidak berdampak buruk terhadap nilai tingkat kelangsungan hidup benih ikan nila merah. Dalam penelitian ini, perlakuan santan 7 ml/L merupakan perlakuan terbaik yakni dapat menghasilkan nisbah kelamin jantan sebesar 67,78 ± 4,16%.

Kata kunci: fitosteroid, ikan nila, maskulinisasi, monoseks, santan kelapa
Tindakan Sosial Masyarakat Dalam Pemenuhan Air Bersih Pada Daerah Kekeringan di Dusun Tlogopule Kabupaten Tuban
Authors: Mulyono Joko , Priantika Dinda Margesta 
Published: October 2023

The limitations of water sources and continuous water services are the problems of water crises that occur year after year in areas prone to drought. In the face of this condition, people take various actions to fulfill clean water used for daily necessities. The location of this study is in Tlogopule Hamlet, Prunggahan Kulon Village, Semanding District, Tuban Regency. This study used a qualitative descriptive approach, with data collection techniques through observation, interviews and documentation. The study used Max Weber's theory of Social Action, in which actions were performed based on specific reasons and goals to be achieved. In this study, we used three theories out of four proposed by Max Weber. Got that result; 1. The act of Instrumental Rationality is carried out by buying clean water, looking for water in wells, washing at neighboring village water sources and subscribing to water at neighboring village HIPPAM; 2. Value measures by performing the act of receiving clean water aid and water subscription fees with neighbors; 3. Traditional actions by making talang and jeding (waterproofing) to hold rainwater. The water crisis that continues to occur, especially during the dry season, has led the public to the understanding that drought is a common disaster. Drought has brought the community's customs of working together to survive and coexist with drought.
Pengembangan Media Video Pembelajaran Rias Fantasi di Jurusan Tata Kecantikan SMK Negeri 6 Padang
Authors: Delanda Meisy Saskia , Hayatunnufus  
Published: October 2023

Tujuan penelitian ini adalah untuk mengembangkan media video pembelajaran dan mengetahui tingkat kevalidan, kepraktisan dan keefektifitasan media video pembelajaran pada mata pelajaran rias fantasi dengan berbagai tema di SMK Negeri 6 Padang. Jenis penelitian ini adalah penelitian dan pengembangan dengan menggunakan langkah 4-D. Populasi penelitian adalah peserta didik kelas X KCII tata kecantikan SMK Negeri 6 Padang tahun ajaran 2022/2023 yang berjumlah 36 orang. Teknik pengumpulan data menggunakan angket. Teknik analisis data dengan menghitung skor penilaian video dari angket yang diberikan dan dikategorikan sesuai dengan analisis data menggunakan uji t. Perolehan hasil penelitian ini adalah video telah dikembangkan dengan model pengembangan 4-D, hasil validitas video oleh ahli media 0.90 dan validitas materi diperoleh nilai 0.92 dengan valid, hasil uji praktikalitas video dari respon guru memperoleh nilai 97% dengan kategori sangat praktis dan dari respon peserta didik mendapatkan nilai 80.91% dengan kategori sangat praktis, hasil uji efektivitas diperoleh hasil pre-test 38,88% dan post-test diperoleh hasil 91,66% dengan kategori efektif video di gunakan di SMK Negeri 6 Kota Padang. Dari perolehan hasil tersebut, maka video telah layak, praktis dan efektif untuk digunakan sebagai bahan ajar dikelas.
Multi-Product Quantity Discount
Authors: Liu Zuofeng 
Published: October 2023

Abstract

For products with different quantity discount strategies, sellers need to manually unify their quantity discount strategies for offering multi-product quantity discounts. Is it possible to develop an algorithm to automatically and efficiently provide reasonable quantity discounts for any product combinations while keeping each product’s personal-ized quantity discount strategy? This is the objective achieved via a brand-new approach in this paper. By analyzing the logic behind tra-ditional quantity discounts, I find the method to achieve the goal of this paper and use the rigorous mathematical method to develop a multi-product quantity discount algorithm that supports both contin-uous mode and discrete mode. As far as the relations of products’ quantities and prices are concerned, the new algorithm can accurately coordinate the benefits of buyers and sellers. As a result, it can be widely used in various fields where the relations of all parties’ benefits can be mapped to the relations of products’ quantities and prices.
Olfactory Impairment in Parkinson's Disease:Olfactory Impairment in Parkinson's Disease:
Its Frequency and Correlation to Clinical severity in Sudanese
Patients,Wad-Medani Teaching Hospital, 2022
Authors: Daoud Mahmoud Hussien Salih , Shama Ejlal Ahmed Ebrahim Abu , Mukhtar Wail Nuri Osman , Elsayed Muaz Abdellatif Mohammed , Ali Khalid Mohammed , Elamin Abubakr Elmotesim Abdulla 
Published: October 2023

Abstract
Background: The olfactory impairment is the most common non-motor symptom in Parkinson's disease (PD) . It may predate the onset of Parkinson's disease by several years and it is one of the supportive criteria for the diagnosis. It's presence is also related to rapid disease progression and more pronounced impairment of Motor symptoms.
Objective: The aim of this study is to determine the frequency of olfactory impairment in patients with Idiopathic Parkinson's disease and it's correlation to the clinical severity of the disease.
Methods: This is a cross sectional hospital based study, carried out at Wad-Medani Teaching Hospital at the Neurology Department over a period of four months; from March to July 2022. Data was collected using a validated version of olfactory questionnaire and Hoehn and yahr scale , our study covered all PD patients who were fitting the inclusion criteria. Data was processed and analyzed using SPSS version 25.
Results: The study included 61 patients, males were 32 (52.46 %) and females were 29(47.54%). The mean age of patients was 63.8 +/- 12.3 SD, about 76% of them had been diagnosed within less than 5 years. Most patients 48 (78. 7 %) were normosmic and only 13 (21.3%) had hyposmia ranging from mild to Severe form. Male patients had higher Frequency of anosmia 9 cases (69.3 %) compared to females (30.7%), the P value was (0.012) statistically significant for sex difference in olfactory dysfunction . The highest number of cases 24 (39.3%) were in stage 3 of Hoehn and yahr (H & Y) scale. There is statistically significant correlation between the scale and the degree of hyposmia (P value <0.013). The study also showed that in near half (45.5%) of hyposmia patients the olfactory impairment had antedated the Parkinsonism by mean of 4.8 +/- 1.6 years.
Conclusion: The study concluded that the olfactory impairment presents in about one fifth of Parkinson's disease patients, with male predominance and was associated with more severe impairment in motor performance scales. It also predates PD in about half of the patients by mean of 4.8 years.
Unravelling the Social and Economic Consequences of Climate Change on Sustainable Livelihoods on Coastal Communities in South Africa
Authors: Adom Richard Kwame , Simatele Mulala Danny , Das Dillip Kmar 
Published: October 2023

Abstract
Coastal regions are vital to numerous local economies and the national development of countries globally, including South Africa, due to their significant contributions to job creation, marine transportation, offshore drilling, resource extraction, fish cultivation, recreation and tourism. Despite these contributions to the coastal regions, the coastal communities are threatened by climate change in the form of sea level rise, floods, pollution, coastal erosion, changes to shorelines, extensive damage to critical infrastructure and destruction of coastal livelihoods. While these threats are increasingly hard to overlook, many governments and local administrators, including South Africa, have yet to prepare or implement strategies to meet these menaces adequately. Using mixed method approach of qualitative and quantitative, and extensive literature reviews, this paper explores the consequences of climate change on coastal livelihoods in South Africa. Our findings established that the country's coastal areas are under severe threats with high risks of submergence of floods, saltwater intrusion into surface and groundwater, increased erosion and overwhelmingly negative social and economic repercussions. This paper recommends a higher sense of urgency in addressing climate change threats and a much stronger implementation framework in climate change governance in the country, especially in the coastal zones.
Increased occupational exposure to physical stress in wild-type transthyretin amyloid cardiomyopathy – a potential disease promoting mechanism?
Authors: Klarskov Valentin Rosenkrans , Ladefoged Bertil Thyrsted , Pedersen Anders Lehmann Dahl , Hartig-Andreasen Charlotte , Poulsen Steen Hvitfeldt 
Published: October 2023

Abstract
Background
The cause of wild-type transthyretin amyloidosis cardiomyopathy (ATTRwt) remains unknown, with mechanical stress being hypothesized as a potential mechanism. No study has investigated the potential impact of occupational physical exposure on ATTRwt development.
Methods
We enrolled 100 participants, including 50 ATTRwt patients with prior carpal tunnel syndrome surgery (CTS), 25 ATTRwt patients without CTS, and 25 age- and gender-matched stable heart failure patients with reduced ejection fraction (HFrEF) as controls. We evaluated self-reported physical work exposure, Danish occupation classification (DISCO-88), history of orthopedic joint-related disorders beyond CTS surgery, hand volumes, and physical status using the Kansas City Cardiomyopathy Questionnaire.
Results
ATTRwt patients had significantly higher physical work exposure than the HFrEF control group (p<0.001), with a higher prevalence of blue-collar work. Knee or hip joint replacement was more frequent in ATTRwt patients (31; 41%) compared to HFrEF patients (2; 8%). ATTRwt patients exhibited larger hand volumes than the HFrEF control group (dominant hand [DH]: 518±80 mL vs. 421±64 mL, p<0.001).
Conclusion
These findings support the hypothesis that long-standing mechanical stress might play an important role in the development of ATTRwt cardiomyopathy and associated ligament disorders.
Trial registration
The study was approved by the Committee of Scientific Ethics of the Central Denmark Region (project ID: 1-10-72-380-21). Date of registration: 17/03/2022. The study was registered with clinicaltrials.org (ID: NCT05896904). Date: 09/06/2023.
Enhancing weakly supervised learning for histopathology images by incorporating the significance ratio
Authors: Wang Shuhao , Xu Gang , Zhao Lingyu , Chen Xiao , Wang Tongwei , Wang Lang , Luo Zhenwei , Wang Dahan , Zhang Zewen , Liu Aijun , Ba Wei , Song Zhigang , Shi Huaiyin , Zhong Dingrong , Ma Jianpeng 
Published: October 2023

Abstract
Histopathology image analysis plays a crucial role in cancer diagnosis. However, training a clinically applicable segmentation algorithm requires pathologists to engage in labour-intensive labelling. In contrast, weakly supervised learning methods, which only require coarse-grained labels at the image level, can significantly reduce the labeling efforts. Unfortunately, while these methods perform reasonably well in slide-level prediction, their ability to locate cancerous regions, which is essential for many clinical applications, remains unsatisfactory. Previously, we proposed CAMEL, which achieves comparable results to those of fully supervised baselines in pixel-level segmentation. However, CAMEL requires 1,280×1,280 image-level binary annotations for positive WSIs. Here, we present CAMEL2, by introducing a threshold of the cancerous ratio for positive bags, it allows us to better utilize the information, consequently enabling us to scale up the image-level setting from 1,280×1,280 to 5,120×5,120 while maintaining the accuracy. Our results with various datasets, demonstrate that CAMEL2, with the help of 5,120×5,120 image-level binary annotations, which are easy to annotate, achieves comparable performance to that of a fully supervised baseline in both instance- and slide-level classifications.
Development and validation of TreatHSP-QoL – a patient-reported outcome measure for health-related quality of life in hereditary spastic paraplegia
Authors: Malina Jekaterina , Huessler Eva-Maria , Jöckel Karl-Heinz , Boog-Whiteside Eva , Jeschonneck Nicole , Schröder Bernadette , Schüle Rebecca , Kühl Tobias , Klebe Stephan 
Published: October 2023

Abstract
Background.
Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disease that lacks specific and validated patient-centered outcome measures (PCOMs). We aimed to develop and validate a health-related quality of life (HRQoL) questionnaire specific to HSP (“TreatHSP-QoL”) that could be used as a PCOM.
Results.
The pilot-items of the TreatHSP-QoL (45 five-level Likert scale items, with values per item between 0–4) were developed based on a qualitative data analysis of 54 semi-structured interviews, conducted in person with 36 HSP patients and 18 caregivers. It was then reduced and modified through the validation process to 25 items. The main validation was performed using the online questionnaire in 242 HSP patients and 56 caregivers. The exploratory factor analysis defined five subdomains. Cronbach’s alpha ranged from 0.57–0.85 for the subdomains and reached 0.85 for the total score. The test-retest correlation reached 0.86. Correlations with the EuroQol-5 Dimension (5 levels) (EQ-5D-5L) and Friedreich Ataxia Rating Scale-Activities of Daily Living (FARS-ADL) questionnaires varied strongly among the subdomains, with the total scores reaching 0.53 and − 0.45, respectively. The caregiver-patient response correlation ranged between 0.64–0.82 for subdomains and reached 0.65 for the total score.
Conclusions.
TreatHSP-QoL can be used in high-quality clinical trials and clinical practice as a disease-specific PCOM (i.e., HRQoL measure) and is also applicable as a proxy questionnaire. Score values between 0-100 can be reached, where higher value represents better HRQoL. The variable correlations to the EQ-5D-5L and FARS-ADL support the specificity for HSP. All in all, the results demonstrate good validity and reliability for this new patient-centered questionnaire for HSP.