bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biofortification with selenium as an alternative to increase the total phenolic compounds in brassicas: a systematic review and meta‐analysis
Authors: Kamchen Camila Menezes , de Oliveira Fellipe Lopes , de Souza Thamara Rosa , Vieira Bruno Serpa , Telles Bruna , Morzelle Maressa Caldeira 
Published: October 2023

AbstractThe ability of brassicas to accumulate selenium is crucial for their positive effects on health. Selenium improves the immune system and the antioxidant defenses. Selenium biofortification of brassicas has therefore been explored to increase dietary selenium intake in humans. However, the effects of selenium biofortification on bioactive compounds, mainly phenolic compounds, are not clear. So, this systematic review and meta‐analysis aimed to answer the question ‘What are effects of the biofortification of brassicas with selenium on total phenolic compounds?’ Ten studies, which assessed the effect of selenium biofortification on total phenolic compounds, were selected for qualitative synthesis and four studies were included in the meta‐analysis after a thorough literature review of the PubMed, Science Direct, and Web of Knowledge databases. The quality of the evidence ranged from high to moderate. The meta‐analysis results indicated that the total phenolic compound content was significantly higher (P = 0.002) in the supplemented group but the results showed considerable heterogeneity (P < 0.00001, I2 = 97%) between studies. This systematic review and meta‐analysis summarizes the effect of Se biofortification on the increase in the content of total phenolic compounds and it suggests that several factors can affect this relationship. © 2023 Society of Chemical Industry.
Comparing written exposure therapy delivered via telehealth to trauma‐focused expressive writing in undergraduates: A proof‐of‐concept trial
Authors: Ellis Robyn A. , Darnell Benjamin C. , Orcutt Holly K. 
Published: October 2023

AbstractThe literature demonstrates that posttraumatic stress disorder (PTSD) rates are estimated to be higher on college campuses compared to lifetime estimates in the general population. Written exposure therapy (WET) is a promising brief intervention for posttraumatic stress symptoms (PTSS) with a growing literature of evidence suggesting efficacy, lower drop‐out rates compared to other evidence‐based protocols, and long‐term treatment gains. This proof‐of‐concept study examined the efficacy of WET delivered via telehealth compared to expressive writing (EW), the protocol from which WET was derived. The sample included non–treatment‐seeking trauma‐exposed undergraduate students (N = 33) with elevated PTSS. The results suggest that both WET, g = 1.26, and EW, g = 0.61, were associated with within‐person decreases in PTSS. However, reliable change indices indicated that a significantly larger proportion of individuals in the WET condition (61.5%) demonstrated reliable symptom improvement compared to those who received EW (20.0%), g = 0.91. Contrary to our hypotheses, the WET and EW groups did not differ on reliable slopes of change; however, between‐group effects were underpowered and should be interpreted with caution. These findings offer preliminary support for WET delivered via telehealth, including for individuals with subthreshold PTSS.
Tumor‐derived Vimentin as a novel biomarker for distinct subtypes predicting adjuvant chemotherapy resistance and T‐cell‐inflamed phenotype in small cell lung cancer
Authors: Deng Chaoqiang , Wang Yue , Fu Fangqiu , Li Di , Zheng Qiang , Jin Yan , Li Yuan , Chen Haiquan , Zhang Yang 
Published: October 2023

AbstractDespite recent progress in subtype classification for small cell lung carcinoma (SCLC), little is known about the biomarker for triple‐negative (ASCL1, NEUROD1, and POU2F3 negative) tumors. The long‐term survival, adjuvant chemotherapy (ACT) response, and immune milieu in different SCLC subtypes have also not been well established. Here, we retrospectively collected a large cohort of 192 primary SCLC tumors and reported that ASCL1‐, NEUROD1‐ and POU2F3‐dominant subtypes counted for 61.38%, 19.31%, and 6.21%, respectively. Subtype intra‐tumoral heterogeneity and co‐expression at the single‐cell level existed substantially. The expression of tumor‐derived Vimentin (VIM) was nearly restricted to triple‐negative SCLC tumors (15/19, 78.9%) while YAP1 expression was distributed widely in other subtypes. The SCLC subtyping model was independently prognostic of OS and RFS (p <  0.001 and p = 0.043). In particular, patients with ASCL1‐positive SCLC tumors can benefit more from ACT, and VIM‐positive tumors did the opposite. Compared with other subtypes, the VIM‐dominant SCLC subtype was associated with abundant but functionally impaired CD4+ and CD8+ T‐cells, which highly expressed inhibitory checkpoints and potentially benefit from PD‐L1 blockade therapy. Our study showed that tumor‐derived SCLC‐V subtype could independently predict ACT response. The distinct immune landscape between subtypes may help inform personalized immune therapeutic approaches.
Ultra‐high static magnetic fields cause immunosuppression through disrupting B‐cell peripheral differentiation and negatively regulating BCR signaling
Authors: Gu Heng , Fu Yufan , Yu Biao , Luo Li , Kang Danqing , Xie Miaomiao , Jing Yukai , Chen Qiuyue , Zhang Xin , Lai Juan , Guan Fei , Forsman Huamei , Shi Junming , Yang Lu , Lei Jiahui , Du Xingrong , Zhang Xin , Liu Chaohong 
Published: October 2023

AbstractTo increase the imaging resolution and detection capability, the field strength of static magnetic fields (SMFs) in magnetic resonance imaging (MRI) has significantly increased in the past few decades. However, research on the side effects of high magnetic field is still very inadequate and the effects of SMF above 1 T (Tesla) on B cells have never been reported. Here, we show that 33.0 T ultra‐high SMF exposure causes immunosuppression and disrupts B cell differentiation and signaling. 33.0 T SMF treatment resulted in disturbance of B cell peripheral differentiation and antibody secretion and reduced the expression of IgM on B cell membrane, and these might be intensity dependent. In addition, mice exposed to 33.0 T SMF showed inhibition on early activation of B cells, including B cell spreading, B cell receptor clustering and signalosome recruitment, and depression of both positive and negative molecules in the proximal BCR signaling, as well as impaired actin reorganization. Sequencing and gene enrichment analysis showed that SMF stimulation also affects splenic B cells' transcriptome and metabolic pathways. Therefore, in the clinical application of MRI, we should consider the influence of SMF on the immune system and choose the optimal intensity for treatment.
Strategic employment of immigrant and native workers: Was the green card lottery a game changer?
Authors: Allen W. David 
Published: October 2023

AbstractThis paper examines how employers strategically use immigrant and native workers, within the empirical setting of the U.S. Diversity Immigrant Visa (DIV) program and the National Football League (NFL). Strategic organizations determine their own optimal immigrant‐native mix and consider similar actions and reactions by rival employers, a noncooperative game. DIVs exogenously increased the labor market presence of immigrants. I exploit this fact to examine how NFL clubs subsequently altered their employment of immigrant players. Panel‐based empirical analysis illustrates the hypothesized prevalence of matching in immigrant use among rival clubs, sensitivity of that equilibrium to immigration era, and heterogeneous occupational and organizational consequences.
Comparison of record linkage software for deduplicating patient identities in California's Prescription Drug Monitoring Program
Authors: Stewart Susan L. , Crawford Andrew , Shev Aaron B. , Wintemute Garen , Tseregounis Iraklis Erik , Henry Stephen G. 
Published: October 2023

AbstractBackgroundTo help prevent overdose deaths involving prescription drugs, accurate linkage of prescription drug monitoring program (PDMP) records for individual patients is essential.ObjectivesTo compare the accuracy of the linkage program used by California's PDMP against various record linkage programs with respect to accuracy in deduplicating patient identities in the PDMP, with implications for identifying high‐risk opioid use and outlier behaviors.Research DesignWe evaluated California's program, Link Plus, LinkSolv, and The Link King on 557 861 PDMP identity records with addresses in two 3‐digit zip code areas for patients who filled a controlled substance prescription in 2013. Manual review was performed on a stratified sample of 720 paired records identified as matches by at least one program.MeasuresWe estimated sensitivity and positive predictive value, and computed PDMP patient alerts for the patient entities identified by each program.ResultsSensitivity was 95% for LinkSolv and The Link King, 84% for Link Plus, and 73% for California's program; positive predictive value was ≥93% for all programs. The number of patient entities prompting a PDMP alert was similar among the programs for all alerts except multiple provider episodes (obtaining prescriptions from ≥6 prescribers or ≥6 pharmacies in the last 6 months), which were 10.9%, 26.6%, and 16.9% greater using The Link King, Link Plus, and LinkSolv, respectively, compared to California's program.ConclusionsPDMPs should assess the accuracy of record linkage algorithms and the impacts of these algorithms on patient safety alerts and develop national best practices for PDMP record linkage.
Predicting current and future potential distributions of the greater bandicoot rat (Bandicota indica) under climate change conditions
Authors: Lin Siliang , Yao Dandan , Jiang Hongxue , Qin Jiao , Feng Zhiyong 
Published: October 2023

AbstractBACKGROUNDRodent infestation is a global problem. Rodents cause huge harm to agriculture, forestry, and animal husbandry around the world and spread various zoonoses. In this study, we simulated the potentially suitable habitats of Bandicota indica and predicted the impact of future climate change on its distribution under different socio‐economic pathway scenarios of CMIP6 using a parameter‐optimized maximum entropy (MaxEnt) model.RESULTSThe average area under the receiver operating characteristic curve (AUC) value (0.958 ± 0.006) after ten repetitions proved the high accuracy of the MaxEnt model. Model results show that the annual mean temperature (≥ 15.93 °C), isothermality (28.52–80.49%), annual precipitation (780.13–3863.13 mm), precipitation of the warmest quarter (≥ 204.37 mm), and nighttime light (≥ 3.38) were important limiting environmental variables for the distribution of B. indica. Under current climate conditions, the projected potential suitable habitats for B. indica were mainly in India, China, Myanmar, Thailand, and Vietnam, which cover a total area of 301.70 × 104 km2. The potentially suitable areas of B. indica in the world will expand under different future climate change scenarios by 1.61–17.65%.CONCLUSIONSThese results validate the potential influence of climate change on the distribution of B. indica and aid in understanding the linkages between B. indica niches and the relevant environment, thereby identifying urgent management areas where interventions may be necessary to develop feasible early warning and prevention strategies to protect against this rodent's spread. © 2023 Society of Chemical Industry.
Analysis of dynamic models by optimization
Authors: Moxnes Erling , Naumov Sergey 
Published: October 2023

AbstractDecision‐makers use system dynamics models to understand how model structure causes problematic behaviors, and how the structure should be changed to improve performance. However, understanding problem behavior and designing policies can be complicated without analytical tools. Existing methods focus on feedback loops that drive dynamic behavior. We propose a new method, Analysis of Dynamic Models by Optimization (ADMO), which focuses on understanding the causes of well‐defined problems and on guiding system and policy design. Unlike existing methods, ADMO can evaluate the influence of exogenous variables and nonlinearities, leading to new understandings of endogenous behavior and providing insights for policy design. ADMO can be employed with any model, including differential equation, agent‐based, discrete event, or hybrid, requiring minimal effort. Two cases demonstrate the application of ADMO to analyze problems and improve both system design and policies. © 2023 The Authors. System Dynamics Review published by John Wiley & Sons Ltd on behalf of System Dynamics Society.
Enhanced Photocatalytic Performance of g‐C3N4@MnFe2O4 Nanocomposite for Crystal Violet Dye Degradation under Solar Light
Authors: Rathore Roshni , Waghmare Aakash , Rai Sarita , Chandra Vimlesh 
Published: October 2023

AbstractCrystal violet (CV) dye has been used in the textile industry, as printing ink, biological stain, and antimicrobial agent. CV dye persists in water for a long time and poses a serious threat to humans and aquatic life. In this study, g‐C3N4, MnFe2O4 nanoparticles, and g‐C3N4@MnFe2O4 (80 : 20 wt %) nanocomposite were synthesized via thermal decomposition and chemical co‐precipitation routes. The crystallite size was found 36.31 nm and 30 nm for bare MnFe2O4 nanoparticle and g‐C3N4@MnFe2O4 nanocomposite respectively. The optical band gaps of MnFe2O4, g‐C3N4, and g‐C3N4@MnFe2O4 were 1.8 eV, 2.7 eV, and 2.4 eV, respectively. The photoluminescence intensity decreases in the following order: g‐C3N4>g‐C3N4@MnFe2O4 nanocomposite>MnFe2O4. The degradation efficiency of MnFe2O4, g‐C3N4, and g‐C3N4@MnFe2O4 nanocomposite was found to be 25.13 %, 58.11 %, and 98.42 % respectively, and followed first‐order kinetics. The value of the rate constant for g‐C3N4@MnFe2O4 was 0.022 min−1 which was around ten times higher than g‐C3N4 and MnFe2O4. By adding three scavengers, the degradation capacity of nanocomposite was decreased in the order AA (L‐ascorbic acid)>EDTA (ethylenediaminetetraacetic acid)>TBA (t‐butyl alcohol). A slight reduction in degradation efficiency was observed after five consecutive cycles. Thus, this new finding can be applied to the degradation of CV dye‐contaminated industrial wastewater under solar light.
Recycling of Hazelnut Husk; from Bio‐waste to Phyto‐Assisted Synthesis of Silver Nanoparticles
Authors: Sivri Damla , Kurel Ali , Baytore Defne Ipek , Akdogan Nilay Gunduz , Akdogan Ozan 
Published: October 2023

AbstractIn the present work, green synthesis is utilized in the synthesis of silver nanoparticles with hazelnut (Corylus Colurna) husk which is the outer leaf part of the hazelnut shell and is considered bio‐waste. According to transmission electron microscopy and x‐ray diffraction analysis, the morphology of the silver nanoparticles synthesized by 0.1 g/mL hazelnut husk extract is found to be spherical with an average diameter of 6.57 nm and possesses ultra‐narrow size distribution. UV‐visible spectrometry reveals the absorbance peak range between 450–475 nm which is in the range of surface plasmon resonance peak of silver nanoparticles with spherical morphology. Antibacterial properties of the synthesized silver nanoparticles were tested on E. coli and significant antimicrobial activity was found with up to 79 % areal inhibition efficiency. The research revealed that the hazelnut husk extract, a reducing agent used in syntheses with different mass concentrations of hazelnut husk extract, also affects the size of the nanoparticles, allowing for the possibility of controlling their size. The antibacterial properties of silver nanoparticles, synthesized in a spherical form of different sizes, correspondingly increased their effect on bacteria which is observed in the inhibition zone. The synthesis of silver nanoparticles, which can be used in many fields for agriculture, cosmetics, and medical purposes, using plant extract and minimal chemicals is crucial because it affects its toxicity. The synthesis of silver nanoparticles with hazelnut husk not only reduces the chemical waste and toxicity, but it is both easily accessible and helps the environment and sustainability by recycling a normally considered bio‐waste by‐product of high‐value‐added crop to a technologically valuable product silver. Moreover, synthesized silver nanoparticles could be an essential part of applications ranging from antibacterial surface treatments to drug delivery systems.
bis‐(Aminophenyl)ferrocene ligand for palladium free CuI catalyzed Csp2−Csp cross‐coupling reaction
Authors: Kashyap Bishwapran , Talukdar Hrishikesh , Phukan Prodeep 
Published: October 2023

AbstractTwo new ferrocene based molecules S,S′‐bis(4‐aminophenyl)ferrocene‐1,1'‐bis(carbothioate) (I) and S,S′‐bis(3‐aminophenyl)ferrocene‐1,1'‐bis(carbothioate) (II) have been synthesized via a thioester linkage. The prepared compounds have been successfully applied as ligands for the CuI catalyzed Sonogashira coupling reaction. The ligands are highly effective for the Csp2−Csp coupling between alkyne and iodobenzene and bromobenzene. Corresponding 1,2‐disubstituted alkynes could be synthesized from both aryl and alkyl alkynes in high yield by using catalytic amount of CuI in presence of bis(3‐aminophenyl)ferrocene derivative in dioxane at 50 °C.
Electrochemical Syntheses of Heterocyclic Compounds Using Transition Metal Catalysts
Authors: Swaroop Toreshettahally R. , Narasimhamurthy Kereyagalahally H. , Umashankara Muddegowda , Rangappa Kanchugarakoppal S. 
Published: October 2023

AbstractIn this review, we present the development of the electrochemical synthesis of heterocyclic compounds catalyzed by transition metal salts and their complexes since 2000. The review is presented as synthesis of nitrogen and oxygen containing heterocycles. The review reflects the applications of transition metal catalysts in the synthesis of aza‐ and oxa‐heterocycles. All reactions are green since they avoid the requirement of chemical oxidants. Electricity as sole oxidant is used to regenerate the active metal catalyst. Thus, in general atom economies of organic electrochemical reactions are high. Nevertheless, use of electrolytes does not affect atom economy. However, one should consider catalytic amount of electrolytes rather than equivalent amount to make electrochemical reactions much green.
Benzylation of 1,3‐Dicarbonyl Compounds with Benzyl Alcohols Promoted by Perfluorosulfonic Acid Resin
Authors: Zhang Yingge , Yang Feng , Pei Supeng , Wang Qingwei , Xu Kangwei , Ma Jialu , Liu Guipeng , Xu Xiaojun , Liu Gaochong , Wang Zhihui , Xu Huiyu , Zhang Yongming , Liu Feng 
Published: October 2023

AbstractThe catalytic performance of Perfluorosulfonic acid resin (PFSA), a solid superacid, was studied in the catalytic benzylation of 1,3‐dicarbonyl compounds with benzylic alcohols. The PFSA‐catalyzed reactions could proceed smoothly to provide the products under solvent‐free conditions or in toluene and dichloromethane, which gave moderate to excellent yields. Due to its high chemical stability, PFSA was quite stable under the reaction conditions and could be recovered at least eight times without significant reduction of its catalytic effect. Moreover, this reaction was investigated at a 20 mmol scale, which indicated the potential applicability of the large‐scale industrial synthesis. Finally, the mechanism of the PFSA‐catalyzed benzylation of 1,3‐dicarbonyl compounds with benzylic alcohols was also investigated.
Titanium‐based MOFs‐derived Cabon‐supported Photocatalysts for the Efficient Degradation of Tetracycline
Authors: Wang Fuying , Zhang Liuxue , Liu Cong , Xu Xuetong , Jia Xu , Liu Shaokang , Wang Xiulian , Zhang Huiqin , Li Aimei 
Published: October 2023

AbstractIn order to eliminate the public health hazard of tetracycline in a more environmentally friendly and efficient manner, a titanium‐based metal‐organic framework material containing Co ions was synthesised as a precursor by the traditional solvothermal method. Subsequently, a series of titanium‐based MOFs‐derived carbon‐supported photocatalysts were synthesised by calcining the precursor at different temperatures in air. All the prepared catalysts achieved effective degradation of the model pollutant tetracycline (TC). By adjusting the parameters such as TC concentration, catalyst dosage and irradiation time, the optimised composite material (TiCoOC‐800‐1) has a degradation rate of 99.4 % for the model pollutant TC with a concentration of 100 mg/L after under the UV irradiation during 30 min. Radical scavenging experiments showed that the main oxide species responsible for the rapid photodegradation of tetracycline were superoxide radicals (⋅O2−) and holes (h+). Finally, the liquid chromatography mass spectrometry (LC–MS) method was used to detect the molecular degradation intermediates of TC and a possible degradation pathway was proposed. This work will provide new ideas for the development of more efficient photocatalysts for the degradation of TC in wastewater.
Regioselective C(sp2)3−H thiocyanation of substituted 4H‐pyrido[1,2‐a]pyrimidin‐4‐ones and its derivatizations
Authors: Roy Sanjay , Ghosh Prasanjit , Ghosh Shibaji , Mondal Samir K. , Mandal Anirban , Das Sajal 
Published: October 2023

AbstractWe demonstrate herein the first example of K2S2O8 mediated direct C(sp2)−Hthiocyanation of substituted 4H‐pyrido[1,2‐a]pyrimidin‐4‐ones at room temperature in the absence of a metal catalyst. This unique approach features a broad substrate scope with excellent functional group tolerance and substitution patterns, affording the target thiocyanated scaffolds in lucrative yields with exclusive regioselectivity. Mechanistic investigations have also been conducted for better understanding of the reaction pathway. In addition, the synthetic utility of this protocol has been showcased through the construction of biologically relevant analogues.
HO‐3867, a curcumin analog, elicits cell apoptosis and p38‐mediated caspase activation in hepatocellular carcinoma
Authors: Hsueh Kuan‐Chun , Ju Po‐Chung , Hsieh Yi‐Hsien , Su Shih‐Chi , Yeh Chao‐Bin , Lin Chiao‐Wen 
Published: October 2023

AbstractHO‐3867, a synthetic curcumin analog, has displayed various tumor‐suppressive characteristics and improved bioabsorption over its parent compound. However, its influences on the development of hepatocellular carcinoma (HCC) are poorly defined. To address this, we tested the anticarcinogenic impact of HO‐3867 and investigated the underlying mechanisms in fighting liver cancer. Our result demonstrated that HO‐3867 reduced the viability of HCC cells, accompanied by promotion of cell cycle arrest at the sub‐G1 stage and apoptotic responses. Furthermore, a distinctive profile of apoptosis associated proteins, encompassing elevated heme oxygenase‐1 (HO‐1) level and caspase activation, was detected in HO‐3867‐stimulated HCC cells. In addition, such HO‐3867‐mediated elevation in caspase activation was dampened by pharmacological suppression of p38 activities. Taken together, our findings unveiled that HO‐3867 triggered cell cycle arrest and apoptotic events in liver cancer, involving a p38‐mediated activation of caspase cascades. These data highlighted a usefulness of curcumin or its analogs on the management of hepatocarcinogenesis.