bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of different tea brands on color change of flowable resin composite
Authors: YENİÇERİ ÖZATA Merve , BAKIR Elif Pınar , ÜNAL Samican , POLAT Gamze , AKLEYİN Ebru 
Published: December 2023

Aims: This study aimed to evaluate the color change of a low-viscosity fluid resin composite (FRC) aged in 2 different brands of black tea and a Ceylon tea for three different periods (24 hours, 7 days, and 28 days).
Methods: Twenty-eight Filtek Ultimate FRC samples with a diameter of 10 mm and a thickness of 2 mm were prepared and polymerized using polytetrafluoroethylene molds. All samples were numbered and polished, and initial color measurements were made. Samples were divided into three experimental groups and a control group (Distilled water) (n=7). All samples were kept in solutions for 24 hours, 7 days, and 28 days, and at the end of these periods, color measurements were made with a spectrophotometer. Data were recorded according to the CIE Lab system. ΔE was calculated by dividing the sum of squares of the difference of the last and first color measurement values by two. One-way ANOVA and Tukey test were used in the analysis of the data.
Results: The Yellow Label black tea group caused significantly more color change in 24 hours than the Ceylon tea (p
Exploring the impacts of Pycnogenol on pentraxin-3 levels in the heart tissue of rats administered with gentamicin
Authors: ÇAKMAK Tolga 
Published: December 2023

Aims: The present study explored if pentraxin-3 (PTX-3) levels, which would be boosted due to cardiac damage by gentamicin, can be regressed thanks to Pycnogenol, which was also previously shown to have desirable impacts on cardiovascular diseases.
Methods: In the study, we recruited 28 8-10-week-old male Sprague-Dawley rats into four groups: control, gentamicin, gentamycin+Pycnogenol, and Pycnogenol. We stained the tissue samples with hematoxylin-eosin and Masson’s trichome dye for histopathological analysis. Then, malondialdehyde (MDA) levels were measured using the spectrophotometric technique. In addition, we measured PTX-3 levels in the heart tissues by an immunohistochemical method.
Results: We discovered the heart tissue samples of the rats in the control and Pycnogenol groups were histologically normal. As well as mononuclear cell increase and degeneration of cardiac muscle cells, we observed mild congestion in the gentamicin group compared to the control group. Despite more significant damage to the heart tissue in the gentamicin+Pycnogenol group compared to the control group, we found that the histopathological damage regressed in this group compared to the gentamicin group. While PTX-3 immunoreactivity was similar between the control and Pycnogenol groups, it was significantly elevated in the gentamicin group compared to the control group (p < 0.001). Moreover, the gentamicin+Pycnogenol group had decreased PTX-3 immunoreactivity than the gentamicin group. While MDA values followed a similar pattern between the control and Pycnogenol groups, these values were found to be significantly increased in the gentamicin group compared to the control group (p < 0.001). These values, however, were decreased in the gentamicin+Pycnogenol group compared to the gentamicin group.
Conclusion: In a nutshell, the present study was able to demonstrate that gentamicin may lead to cardiac damage by boosting PTX-3 levels and that the damage can be regressed thanks to the Pycnogenol treatment.
Turkish children myopia progression in the urban area, a retrospective evaluation
Authors: KAYA Pınar 
Published: December 2023

Aims: To investigate myopia trends and progression in urban school-aged myopic children in Turkey.
Methods: This retrospective study included myopic children aged 6-18 years attending the ophthalmology clinic for regular eye and refractive examinations between 2003 and 2021. Myopia progression was calculated as the difference between the baseline and the last visit spherical equivalent refractive (SER) values. Individuals were further categorized to determine the age-specific myopia progression as 6-11, 12-16, and 17-18 age groups based on the school periods of the country. According to the SER values, individuals were classified into mild, moderate, and high myopic groups.
Results: A total of 602 eyes of 301 children (191 female, 110 male) with a mean age of 11.64±2.81 (6-18) years were included in the study. The mean follow-up time of patients was 37.51±19.18 (6-98) months. The baseline mean SER value was -1.5±1.07 D (range: -0.50 and -5.62) and -2.55±1.50 at the final visit. The overall mean myopia progression was -0.35±0.37 D (range: +0.35 D and -3.75 D/year. There were 46 children between 6-11 years, 173 children between 12-16 years, 82 children between 17-18 years, and the annual SER changes were -0.46±0.40 D; -0.37±0.39 D and -0.26±0.29 D in the groups, respectively (p < 0.001). Baseline, final, and annual myopia progression were greater in females. Although there was no statistical significance, myopia progression was faster in moderate myopes (-0.39±0.33 D/a year), followed by mild (-0.35±0.37 D/a year) and high myopes (-0.21±0.20 D/a year) (p=0.37).
Conclusion: The progression of myopia in school-aged Turkish children from the Western Black Sea Region is comparable to the world. Our study revealed the greater myopia progression in the youngest children, moderate myopia group, and females. Myopia prevention recommendations should be carefully advised to the youngest female ones to reduce myopia progression.
Evaluation of distribution and susceptibility of microorganisms isolated from joint fluid cultures: five-year data
Authors: ER Halil , KOCA Özlem , ÖZEN Nevgün Sepin 
Published: December 2023

Aims: Septic arthritis is joint inflammation. It is an orthopedic emergency that requires prompt diagnosis and treatment. In this study, it was aimed to examine the distribution and antibiotic resistance profiles of microorganisms isolated from joint fluid samples taken from patients who applied to the orthopedic clinic of our hospital in the last five years.
Methods: In our study, 1162 joint fluid samples were sent to the medical microbiology laboratory of our hospital from the orthopedics and traumatology clinic between January 01, 2018 and December 31, 2022. Joint fluid samples taken from clinically appropriate patients under sterile conditions were incubated in a BacT/Alert 3D (Biomerieux, France) culture device. Bacteria isolated from 164 specimens with growth detected, were identified by matrix-mediated laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) based VITEK MS (Biomerieux, France). Antibiotic susceptibility tests were performed on the VITEK 2 Compact (Biomerieux, France) device.
Results: Staphylococcus aureus (S. aureus) (29.3%) and coagulase negative Staphylococci (CNS) (29.3%) were the most commonly grown microorganisms. Other microorganisms grown were Streptococcus spp. (9.1%), Enterococcus spp. (6.1%), Pseudomonas aeruginosa (P. aeuruginosa) (7.3%), Escherichiae coli (E. coli) (4.3%) and Klebsiella pneumoniae (K. pneumoniae) (4.3%). When antibiotic susceptibility results were evaluated according to EUCAST restricted reporting criteria, linezolid in Gram-positive strains, amikacin in Enterobacterales, colistin and tigecycline in nonfermentative Gram-negative bacteria were found to be the most susceptible antibiotics.
Conclusion: The continuous change in antibiotic susceptibility profiles in joint infections, the long duration of treatment and follow-up, and the increase in polymicrobial infections require regular monitoring of culture and antibiotic susceptibility tests. In our study, the distribution of microorganisms isolated from joint fluid samples of our hospital and the determination of antibiotic resistance profiles will contribute to the clinician in terms of guiding empirical treatment.
The effect of direct-acting antivirals (DAA) on confirmed noninvasive fibrous parameters in chronic hepatitis C patients
Authors: BULUT Dilek , SAYAR Merve Sefa , ACAR Ali 
Published: December 2023

Aims: Chronic hepatitis C (CHC) is an important public health problem in terms of the number of people it affects worldwide and the diseases it causes. The high sustained virological response (SVR) rates achieved by the use of direct-acting antiviral (DAA) drugs in the recent period have shown that a new era has begun in this disease. It was aimed to evaluate the effect of DAAs on confirmed noninvasive fibrous parameters together with their effectiveness.
Methods: 75 patients who were started on DAA treatment for CHC were included in the study. In addition, laboratory parameters values at the beginning of the treatment, 12 and 24 weeks after the end of the treatment, hepatitis C virus ribonucleic acid (HCV RNA) results and Aminotransferase-to-Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) scores were compared.
Results: The most common comorbidity in patients is hypertension (HT), and the most common source of transmission is surgical operations. Genotype 1b was the dominant genotype. The SVR rates of all patients 12 and 24 weeks after the end of treatment were 100%. The APRI and FIB-4 scores of the patients decreased significantly at the 12th and 24th weeks at the end of the treatment compared to the beginning of the treatment.
Conclusion: The confirmed noninvasive fibrous parameters used in the treatment of CHC are useful in evaluating the results of the treatments applied.
Autism spectrum disorder: perspectives from paediatricians
Authors: KUL Müslüm , KARA Mahmut Zabit 
Published: December 2023

Aims: Since the first medical contact of children and families is mostly with paediatricians, the knowledge and experience of paediatricians on Autism Spectrum Disorder (ASD) is extremely significant. It was aimed to investigate paediatricians’ general knowledge on ASD, daily practices in the outpatient clinic and ability to recognize warning signs.
Methods: A 40-item questionnaire prepared by the researchers was completed with 116 specialists or subspecialties working in public and private hospitals of two cities in Türkiye.
Results: While 41.7% of paediatricians received rotation training in residency, 32.8 % reported they have enough experience. While 87% considered ASD screening among their duties, only 12.8% stated they have enough time. The number of patients referred for formal assessment of ASD was low. Gender, type of expertise, duration of experience, and sense of competence were not associated with referral frequency. It’s been determined paediatricians have a lack of knowledge about ASD. While not responding to name and difficulty following the instructions were seen as most warning symptoms, other diagnostic criteria and accompanying symptoms were recognized insufficiently.
Conclusions: In addition to increasing the duration and quality of child psychiatry education during residency, regulating the outpatient clinic conditions can overcome an important obstacle in the early diagnosis of ASD.
Evaluation of cardiovascular risk factors, prevalence and determinants of coronary artery disease in renal transplant patients: a single center experience
Authors: CENGİZ ELÇİOĞLU Betül , DEMİRCİ Yasemin , ALTIN Mert Pehlivan , GÜRSOY Erol , AYTEKIN Vedat , AYTEKIN Saide 
Published: December 2023

Aims: Cardiovascular disease is the leading cause of morbidity and mortality in renal transplant patients. In our study, we aimed to determine the cardiovascular (CV) risk factors, the prevalence and determinants of coronary artery disease (CAD) in patients who underwent kidney transplantation in our center.
Methods: One hundred sixty nine patients who underwent kidney transplantation in our center were included in the study retrospectively. Demographic and clinical characteristics of the patients, cardiac evaluation findings and further examination results were scanned from the database of our center.
Results: The mean age of the patients was 42.86±12.97 years and 43.19% were female. The most common etiological factors for the development of end-stage renal disease were hypertension (HT) and diabetes mellitus (DM). Ninety seven patients (57.4%) were undergoing dialysis, 4 of whom were on peritoneal dialysis. Renal transplant was performed from a cadaver in two patients and from a living donor in the other patients. CAD was detected in 29 patients (17.15%). The most prevalent CV risk factors were HT and hyperlipidemia (HL). Multivariate logistic regression analysis revealed that age, DM, HL and dialysis history were independent risk factors for the development of CAD. In the postoperative follow-ups, no death or acute coronary syndrome was observed during the hospitalization period.
Conclusion: Prevalence of CV risk factors is high in renal transplant candidates. Our findings support the need for a detailed cardiac evaluation and effective management of CV risk factors in patients preparing for kidney transplantation.
Conditioned media of tonsil derived mesenchymal stem cells shows different rates of cytotoxicity on solid cancer cells
Authors: YÜCE Melek , ALBAYRAK Esra , GÜMÜŞKAPTAN Çağrı 
Published: December 2023

Aims: Mesenchymal stem cells (MSCs) are the apple of the eye of cancer studies. It was indicated that the secreted factors, especially released by MSCs, have tumoral or anti-tumoral effects on tumor progression. MSCs obtained from different sources show different anti-tumoral effects, while MSCs originating from the same source also show different tumoral effects in different cancer cells. Here, we investigated the anti-tumor effects of soluble factors secreted from palatine tonsil MSCs (TMSC) as a new source of MSC on human lung carcinoma (A549) and pancreatic cancer (PANC-1) cell lines.
Methods: Conditioned medium (CM) was obtained from TMSCs isolated from palatine tonsil tissue, and the cytotoxic effect of CM on the growth of A549 and PANC-1 in a dose-dependent manner was demonstrated by MTT analysis. In addition, the function of CM treatment on the cell cycle status of cancer cells and the apoptosis process were investigated through cell cycle analysis with propidium iodide (PI) and Annexin-V/PI detection method by flow cytometry analysis, respectively.
Results: We demonstrated that TMSC-CM treatment significantly decreased the viability of A549 and PANC-1 cell lines in a dose-dependent manner post-48 hours. In addition, CM treatment differentially induced the apoptosis on A549 and PANC-1 cells and also, caused G2/M arrest in the cells.
Conclusion: In light of these findings, our study is the first to show that TMSC-CM has an anti-tumoral effect by stimulating apoptosis on A549 and PANC-1 cells. These findings reveal that the usage of CM has a cell-free cellular therapeutic potential.
The Late-Epoch, Matter-Bounded Spectrum of the Nova V1405 Cassiopeiae
Authors: Rudy Richard J. , Subasavage John P. , Mauerhan Jon C. 
Published: December 2023

Abstract
Optical and near-infrared spectra of the classical nova V1405 Cassiopeiae (V1405 Cas) from more than two years after outburst show a still bright nova of intermediate excitation with coronal lines, some high-ionization but non-coronal forbidden lines, and very strong emission features of He ii. However, the common nebular lines of [N ii], [O ii], and [O iii] are absent and the lines of He i are very weak. Analysis with the photoionization code CLOUDY indicates a emission line region that is sharply matter-bounded, truncating before the gas excitation drops sufficiently to support the parent ions of lower excitation lines.
Hoverflies of the Timon-David collection (Diptera, Syrphidae)
Authors: Neve Gabriel , Lair Xavier , Lebard Thomas , Meunier Jean-Yves , Teste Louis-Jean , Séguinel Louise 
Published: December 2023

Hoverflies are among the most important insect pollinators and there is documented evidence of a recent decline in their populations. To trace the past distributions of hoverfly species, verified records of historical collections are essential.
Here we provide data on 1071 specimens of hoverflies collected or received by Jean Timon-David and hosted at the Marseille Natural History Museum, France. Most of the specimens were collected by Timon-David himself and come from south-eastern France, mainly from the departments of Bouches-du-Rhône, Var and Hautes-Alpes. Most of these specimens were checked for the accuracy of their identification according to the latest identification keys. This resulted in 85 additions to the known fauna of the French departments, mostly for Var and Bouches-du-Rhône. The taxonomy of all specimens was checked against the latest available checklists, and updated names added whenever necessary. Specimens received from entomologists working in other continents may also be valuable, as these are historic testimonies of the fauna of their own respective regions of origin, and may therefore also be used as reference material. One paratype specimen from Australia is present in the collection. The holotype of Cheilosia vangaveri Timon-David, 1937 is absent from the collection and should be considered as lost. All but two of the specimens with locality labels had their geographical coordinates of origin added in the data set.
Les espaces ruraux de Lituanie : des dynamiques spatiales hétérogènes ?
Authors: Chevalier Pascal , Maciulyte Jurgita , Dedeire Marc 
Published: December 2023

Dans cet article, il est question de renouveler et réinterpréter la lecture de la recomposition rurale, dans ses formes les plus variées, par une analyse comparative à l’échelle d’un pays ayant jadis appartenu à l’Union Soviétique et, aujourd’hui, membre de l’UE : la Lituanie. Plus largement, la contribution propose de mesurer la part des facteurs endogènes et exogènes explicatifs de la recomposition contemporaine rurale en présentant un travail de cartographie statistique multivariée à l’échelle des provinces rurales (NUTS 4) qui rendra compte de la complexité et de la différenciation spatiale des formes d’intégration socio-économique des territoires ruraux lituaniens. Comment se traduisent-elles spatialement et quelles formes prennent-elles selon la nature des espaces ruraux régionaux et leur proximité à la ville ?
Péguy polémiste et l’idée d’œuvre
Authors: Barral Céline 
Published: December 2023

Le Péguy polémiste des Cahiers de la quinzaine (1900-1914) n’était pas moins écrivain que le Péguy poète et auteur de mystères. Mais la forme de sa revue a pu constituer un obstacle à sa reconnaissance comme écrivain. L’article interroge le rapport ambigu que Péguy a entretenu avec le format-roi du livre, entre mystique et détestation. L’entreprise collective et expérimentale des Cahiers doit-elle être considérée comme un laboratoire de livres à venir ou un empêchement à la naissance de livres autonomes, voire un lieu d’extinction de la littérature ? Malgré le glissement progressif des « cahiers de documents » des premières séries vers un format plus homogène de cahiers-livres, Péguy a proposé d’autres formes de « mises en œuvre », par remembrement et présentation tabulaire, où l’auctorialité et la composition textuelle s’émancipent des principes du livre.
« Sur la route ». Réflexions sur un chronotope péguyste
Authors: Gendrel Bernard 
Published: December 2023

Même si le concept de chronotope a surtout été utilisé pour l’étude du roman, il convient tout particulièrement au traitement de la « route » dans l’œuvre de Péguy. Lieu éminemment concret, dans lequel le temps vient lui-même se concrétiser, la route est au centre de deux grandes œuvres poétiques, Suite d’Ève et Présentation de la Beauce à Notre-Dame de Chartres , qui en éclairent chacune un aspect. Prendre la route, ce n’est que marcher et c’est plus que marcher : c’est faire l’épreuve physique du temps, c’est s’inscrire dans une histoire qui nous dépasse et c’est œuvrer contre tous les immobilismes qui nous menacent.
Enjeux d’intégration économique et territoriale des tiers-lieux en Normandie
Authors: Nadou Fabien , Kemdji Matthieu 
Published: December 2023

L’extension des politiques locales de développement en faveur du soutien aux Tiers-lieux (TL) interroge leurs capacités à s’inscrire dans les dynamiques socio-économiques des territoires. Beaucoup affirment leurs volontés de réunir des individus dans un lieu particulier propice à faire émerger des projets collaboratifs, quand d’autres affichent explicitement d’être pensés en phase avec les dynamiques économiques de leurs territoires. Aujourd'hui, même si investi sur l'ensemble des territoires, l'objet TL semble répondre à un certain modèle économique en manque de certitude et continue de se propager dans toute la France. Notre contribution donne des clés d'analyse et participe à la valorisation scientifique d’une mission de recherche-appliquée, commanditée par le groupe Action Logement (entre 2019 et 2021). Dans un premier temps, elle expose un état de l’art de cet « objet » sous le prisme de la littérature existante des TL et des sciences régionales. Puis, dans un second temps, nous appliquons une méthode ASR dans les zones d’emplois (ZE) de quinze territoires normands, ayant pour objectif la promotion des TL d’une part et la redynamisation économique d’autre part, identifié par le plan interministériel « Action Cœur de Ville » (ACV). Nous croisons nos résultats à l’échelle du dispositif de labélisation régional « Tiers-lieux en Normandie » (TLN) afin d’interroger ce problème d’articulation. Nous proposons trois études de cas ou dialogues entre les territoires et les TL normands. L’un des principaux résultats concerne le manque de visibilité ou de cas d’usages par l’ensemble des acteurs du territoire.
Clinical and microbiological pattern of intertrigo
Authors: Wickramanayake A.B. , Sigera L.S.M. , Jayasekera P.I. , Patabendige G. , Akarawita J.K.W. 
Published: December 2023

Background: Intertrigo is a common disorder affecting many flexural areas of the body with significant morbidity.
Objectives: To determine the clinical pattern of intertrigo. To determine bacterial and fungal pathogens associated with intertrigo. To assess the antibacterial and antifungal sensitivity pattern of the responsible organisms.
Methods: A total number of 230 patients with intertrigo attending dermatology unit were included in the study after ethical clearance. Laboratory investigations were done to identify the etiologic agent and their sensitivity pattern.
Results: Majority of patients (75%) belonged to 20-60 years of age. Male to female ratio was 1.15:1. Remarkable proportion (52%) presented with the involvement of more than one intertriginous area. The most common site involved was toe web space (63%) in particular 4th toe web space. Of all positive bacterial cultures 45% revealed Staphylococcus aureus (MSSA+MRSA) followed by CNSA (Coagulase negative Staphylococcal aureus), diptheroids and pseudomonas. The majority of MSSA (Methicillin sensitive Staphylococcus aureus) isolates (91%) were sensitive to cloxacillin and MRSA (Methicillin resistant Staphylococcus aureus) to teicoplanin (85%). CNSA isolates showed considerable proportion of sensitivity to vancomycin (37%) and majority of diptheroids isolates were sensitive to penicillin(87%). All isolates (100%) of pseudomonas were sensitive to gentamicin. Of all positive fungal cultures, candida species constituted the majority (35%) followed by fusarium species (33%) and dermatophytes (30%). Overall fusarium species shows high value of MIC50 and MIC90 for itraconazole, fluconazole and ketoconazole. Fluconazole showed very high MIC50 and MIC90 (256 ug/ml) for dermatophytes and fusarium species whereas itraconazole and ketoconazole showed lower MIC for these fungi.
Conclusion: Intertrigo can affect various intertriginous areas, among which toe web space is the most common region involved. Intertrigo can be caused by a variety of organisms: Staphylococcus aureus and candida species constituted the majority of cases. Majority of MSSA sensitive to cloxacillin and MRSA to teicoplanin. MIC of itraconazole, fluconazole and ketoconazole are high in fusarium species comparing to candida and dermatophytes. However, itraconazole and ketoconazole had lower MIC than dermatophytes and fusarium comparing to fluconazole.