bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluor‐Fucosylierung ermöglicht die Untersuchung der Lea‐LecB‐Wechselwirkung durch BioNMR‐Spektroskopie
Authors: Siebold Kathrin , Chikunova Elena , Lorz Nils , Jordan Christina , Gossert Alvar D. , Gilmour Ryan 
Published: February 2025

AbstractFucosylierungsmuster von Zelloberflächenglykanen sind wesentliche Vermittler von Erkennungs‐ und Signalfunktionen. Abweichungen in diesen Mustern dienen als wichtige, diagnostische Marker für das Voranschreiten von Krankheiten, weshalb das Verständnis von Fucose‐Protein‐Interaktionen auf molekularer Ebene von entscheidender Bedeutung ist. Die molekulare Modifikation von l‐Fucose (Fuc) an C2 mit Fluor bietet eine Plattform, um die Ubiquität der Fucosylierung mit dem Mangel an Strategien zur Untersuchung ortsspezifischer Wechselwirkungen in Einklang zu bringen. Durch die gezielte Einführung eines pseudo‐äquatorialen Fluors [C(sp3)‐F] neben der anomeren Position kann eine β‐selektive Fucosylierung mit einer Reihe verschiedener Akzeptoren (>50 : 1) erreicht werden. Die Selektivität dieses Prozesses kann durch Änderungen am Donor umgekehrt werden. Die Entwicklung der Reaktion wurde durch den Wunsch initiiert, ein fluoriertes Analogon des Lewis‐Antigens a (F‐Lea) zu konstruieren, bei dem Fluor eine wichtige OH‐Gruppe an C2 ersetzt. Lea ist ein Ligand für Lektin B (LecB) im Krankheitserreger Pseudomonas aeruginosa, daher hat die Untersuchung von Schlüsselinteraktionen in diesem Komplex Auswirkungen auf die Arzneimittelentwicklung. Unabhängige Synthesen von Lea und F‐Lea und systematische BioNMR‐Analysen mit beiden Glykanen haben die wesentliche Rolle von O2 der Fucose gezeigt.
Extendable Synthesis of Organic Cations for In Situ Construction of Hybrid Metal Halides with Near‐Unity Photoluminescence and Strong Second Harmonic Generation
Authors: Han Wenqing , Cheng Puxin , Guan Junjie , Li Quanwen , Wang Yue , Wang Zhihua , Rasing Theo , Zheng Yongshen , Xu Jialiang , Bu Xian‐He 
Published: February 2025

AbstractThe A‐site organic components of organic–inorganic hybrid metal halides (OIHMHs) significantly impact their crystal structure and optoelectronic properties. However, chemical modification of A‐site cations has been mostly limited to commercial organic precursors, which restricts the structural variability of OIHMHs for optimal functionalities. Herein we have proposed an extendable synthesis approach to the direct procurability of various organic cations with desireable structures for the in situ construction of a library of OIHMH materials. The template condensation reaction between dimethyl sulfoxide and acetone derivatives yields A‐site organic cations with exquisite control of modularization and regioselectivity within the OIHMH crystallization system. The as‐fabricated OIHMHs demonstrated highly efficient linear optical photoluminescence or nonlinear optical second harmonic generation, promising potential applications in photonic devices. This in situ synthetic strategy offers a structural extension of OIHMHs and establishes a fundamental methodological platform for screening functional OIHMH materials.
Structured lipids from virgin coconut oil and omega‐3 fatty acids: Process optimization
Authors: Van Nguyen Lanh , Shahidi Fereidoon 
Published: February 2025

AbstractStructured lipids (SLs) containing docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and DHA + EPA were synthesized via enzymatic acidolysis using virgin coconut oil (VCO) as the substrate in n‐hexane. Commercially available enzymes Lipozyme TL IM (produced from Thermomyces lanuginosus, a 1,3‐specific lipase), Lipozyme IM60 (produced from Rhizomucor miehei, a 1,3‐specific lipase), and non‐specific lipase from Candida rugosa (powder) were used as biocatalysts. The T. lanuginosus lipase was chosen to evaluate the effects of various parameters on the incorporation of PUFAs into VCO and to optimize the process. As the enzyme load increased from 1% to 4%, the incorporation of omega‐3 PUFAs also increased; however, it decreased when the enzyme load was further increased to 6%. The incorporation of these fatty acids increased with reaction time from 12 to 36 h but decreased at 48 h. Similarly, the incorporation increased with temperature from 35 to 45 °C, but decreased at 55 and 65 °C. The highest incorporation rates of DHA (18.91%), EPA (30.38%), and DHA + EPA (34.64%) were achieved at a mole ratio of 1:3 (VCO to DHA or EPA) or 1:3:3 (VCO to DHA + EPA), with a 4% enzyme load, 36 h incubation time, and a temperature of 45 °C. A central composite design (CCD) with three levels and three factors—reaction temperature (35, 45, and 55 °C), enzyme amount (2%, 4%, and 6%), and reaction time (24, 36, and 48 h)—was used to model and optimize the reaction conditions via response surface methodology (RSM). Under optimal conditions of 3.3% T. lanuginosus enzyme, 42.22 °C, and 33.38 h, the incorporation rates were 32.92% for DHA, 44.48% for EPA, and 47.04% for DHA + EPA in VCO.
Baby breaths: Honoring Kurt Albertine and his contributions to respiratory research in young mammals and to The Anatomical Record
Authors: Joss‐Moore Lisa A. , Yutzey Katherine E. 
Published: February 2025

AbstractIn January 2021, Kurt Albertine, PhD, stepped down as the Editor of The Anatomical Record after 15 years of dedicated service. As Editor‐In‐Chief, he oversaw incredible growth, expanded scope, and increased impact of the journal. At the same time, he directed an active research lab in neonatal pulmonary biology at the University of Utah, with an exceptional track record of mentoring students, fellows, clinicians, and junior faculty. This special issue of The Anatomical Record honors Kurt's contributions to the journal, as well as to the fields of respiratory anatomy, physiology, and neonatology. Several of the invited papers were contributed by Kurt's collaborators and former trainees who cover topics related to neonatal lamb development, bronchopulmonary dysplasia, postnatal lung pathology, respiratory physiology, and the relationship of anatomy to function. Additional papers relating to Kurt's passion for dinosaur anatomy and human embryonic anatomy based on the Kyoto Collection of Human Embryos and Fetuses. Kurt's tireless enthusiasm for the journal and devotion to the field are reflected in the papers in this special issue in his honor. His tenure at the journal was transformative and provided a foundation for continued growth and impact in anatomical sciences research from dinosaurs to clinical applications in humans. We celebrate Kurt's accomplishments and broader impact on anatomical sciences in this Special Issue of The Anatomical Record.
Core‐Only Calamitic Liquid Crystals: Molecular Design and Optoelectronic Properties
Authors: Rothera Jacob G. , Yu Jessica , AlNajm Karla , Butrus Rita , Ahangari‐Bashash Ethan , Watanabe Lara K. , Rawson Jeremy M. , Dmitrienko Anton , Vukotic V. Nicholas , Eichhorn S. Holger 
Published: February 2025

AbstractThermotropic liquid crystals are typically thought of as requiring a rigid core and flexible side‐chains to exhibit liquid crystallinity, but precedent does exist for retaining liquid crystalline nature without these side‐chains in highly conjugated, para‐substituted aromatic structures, albeit at relatively high temperatures (>300 °C). Hence, this work aims to establish molecular design criteria for promoting liquid crystallinity in heteroaromatic, fully conjugated, core‐only calamitic liquid crystals at sufficiently low phase transition temperatures. The synthesis and characterization of an extensive library of calamitic target structures (32) has been accomplished, where primarily enantiotropic smectic A and nematic phases were observed. Comparison of the mesomorphic properties between different cores and with different terminal functional groups was done and rationalization of the observed differences is attempted through single crystal and computational data. These all‐aromatic compounds also display strong fluorescence in solution and in the solid‐state that extends over most of the visible spectrum and displays quantum yields between 3 % and 95 %.
Chiroptical Properties of Chiral Macrocycles Composed of Axially Chiral Binaphthyl and Bithiophene
Authors: Kawashima Hikari , Tauchi Daiki , Sakura Misa , Tsubaki Kazunori , Hasegawa Masashi 
Published: February 2025

AbstractStereogenic macrocycles composed of axially chiral binaphthyls and bithiophenes were synthesized. The bis(1,5‐cyclooctadiene)nickel(0)‐catalyzed coupling of an enantiomeric precursor yielded a cyclic dimer and trimer with doubly‐twisted and triply‐twisted triangular geometries, respectively. The orientation of the bithiophenes, s‐cis, and s‐trans in the cyclic compounds significantly altered their macrocyclic structure. Mixing of conformers in the cyclic dimer results in complex chiroptical properties, leading to bisignate‐type spectra, which are rarely observed in circularly polarized luminescence.
Evaluation of the Clinical and Genetic Characteristics of Primary Ciliary Dyskinesia Patients With Situs Inversus Totalis
Authors: Kahraman Feyza Ustabas , Jafarov Uzeyir , Yazan Hakan , Yurtsever Ismail , Cakir Erkan , Sayin Gozde Yesil 
Published: February 2025

ABSTRACTBackgroundSitus inversus totalis (SIT) is present in approximately 40%–50% of patients with primary ciliary dyskinesia (PCD). We evaluated the relationships between novel genetic results and the clinical and radiological characteristics of PCD patients with SIT.MethodsThe study included 48 patients diagnosed with PCD and SIT. Demographic and clinical features, disease‐related scores (Bhalla, Primary Ciliary Dyskinesia Rule [PICADAR], and American Thoracic Society [ATS]), and genetic analyses were retrospectively assessed.ResultsThe median age of patients was 13 (6.5–16) years, and parental consanguinity was observed in 43 (89.58%) patients. Bhalla score was available in 31 patients and “moderate and severe” score was observed in 19 (61.29%) patients. The median PICADAR score was 10 (8–11), and 34 (70.83%) patients had a high (≥ 10) PICADAR score. The ATS score was found to be 4 in 24 (50%) patients and 3 in 20 (43.75%) patients. Genetic data were available in 40 patients and mutations were found in 27 (67.5%) patients. The most common pathogenic variants were DNAH5 in 8 (20%), CCDC103 in 4 (10%), and CCDC39 in 3 (7.5%) patients. Subjects with any genetic variants may be older, have a greater frequency of parental consanguinity, higher Bhalla score, and higher ATS score (p < 0.05). DNAH5 mutation was associated with a lower likelihood of neonatal ICU stay and neonatal respiratory distress‐related symptoms (p = 0.036 and 0.015, respectively).ConclusionsSitus abnormalities may be a warning sign for the early diagnosis of PCD. Early diagnosis of PCD through genetic analysis is important for preventing chronic lung pathologies and predicting prognosis and may improve the quality of life.
Leveraging supramolecular systems in biomedical breakthroughs
Authors: Maity Shreya , Deb Vishal Kumar , Mondal Sayani , Chakraborty Akansha , Pramanick Kousik , Adhikari Suman 
Published: February 2025

AbstractSupramolecular systems, intricate assemblies of molecular subunits organized through various intermolecular interactions, offer versatile platforms for diverse applications, including gene therapy, antimicrobial therapy, and cellular engineering. These systems are cost‐effective and environmentally friendly, contributing to their attractiveness in biomaterial design. Furthermore, supramolecular biomaterials based on acyclic, macrocyclic compounds and lipid‐based assembly offer potential applications in distinct types of biomedical approaches. In this context, they can transport several therapeutic agents very effectively to the target site. Supramolecular hydrogels exhibit potent antimicrobial activity by disrupting microbial membranes, offering promising solutions to combat drug‐resistant pathogens. Additionally, supramolecular luminescent nanoparticles enable targeted cell imaging, facilitating disease diagnosis and treatment with high specificity and sensitivity. In cellular engineering, supramolecular assemblies of small molecules demonstrate biological activities, overcoming challenges in cancer treatment by inhibiting signaling pathways and inducing apoptosis in cancer cells. This review emphasizes the applications of supramolecular systems from gene therapy to cellular imaging, tissue engineering, and antimicrobial therapy, showcasing their potential to drive innovation and address pressing healthcare challenges.
Impact of ESG Disclosures on Corporate Financial Performance: An Industry‐Specific Analysis of Indian Firms
Authors: Paridhi  , Ritika  
Published: February 2025

ABSTRACTThis study investigates the relationship between environmental, social, and governance (ESG) practices and return on assets (ROA) in Indian companies, focusing on industry‐specific variations. Using 10 years of panel data across resource‐intensive, consumer‐facing, and service sectors, the analysis employs the system generalized method of moments (GMM) for robust estimation. The results reveal a positive overall effect of ESG practices on ROA, with significant differences across industries. The study uses the categorization of resource‐intensive, consumer‐facing, and service industries to examine the differential effects of ESG factors on ROA. However, environmental scores do not significantly impact ROA, suggesting uniform effects across industries. Social scores enhance ROA without notable industry‐specific differences, while governance scores show varying effects, indicating sector‐specific drivers of profitability. The analysis also highlights the moderating effects of industry categories on the ESG–ROA relationship, suggesting that the impact of ESG practices varies across different sectors. The study also considers the economic effects of COVID‐19, highlighting its marginal impact on ROA and the need for resilient financial strategies. However, the moderating effect of COVID‐19 on this relationship was not significant, indicating limited variation in the ESG–ROA dynamics during the pandemic period except in the governance model. These findings suggest that tailored ESG strategies, aligned with industry‐specific challenges, can optimize financial performance. Policymakers and investors are encouraged to focus on sector‐specific ESG practices to better evaluate company performance and formulate effective regulations. This research contributes to the emerging market context by emphasizing the importance of industry‐specific ESG integration for enhancing financial outcomes.
A Moderated Mediation Model Linking Stakeholder Integration to Green Innovation: A Stakeholder Theory Perspective
Authors: Zhang Jianhua , Noman Muhammad , Ali Adnan , Ali Zeeshan , Qayyum Shanza , Khan Afaq Ahmed , Sherwani Mehkar 
Published: February 2025

ABSTRACTDespite extensive discourse on the significant role of stakeholder integration in sustainability and firm performance, its impact on promoting green innovation (GI) remains underdeveloped in current environmental management literature. To address this gap, our study adopts stakeholder theory to develop a moderated mediation model that examines how and under what conditions stakeholder integration influences GI. Using data from 306 Pakistani‐listed manufacturing firms and employing partial least squares path modeling, our findings confirm the positive impact of stakeholder integration on GI and highlight the partial mediating role of organizational learning capability (OLC). Additionally, the results indicate that environmental scanning moderates the relationship between stakeholder integration and OLC. Overall, these insights contribute to business strategy and environmental management literature by illuminating the critical role of stakeholder integration in driving GI and elucidating the underlying mechanisms involving OLC and environmental scanning.
An Umpolung Approach for C2‐Selective C−H Amination of Azines by Palladium Catalysis
Authors: Wu Qikun , Muto Kei , Yamaguchi Junichiro 
Published: February 2025

AbstractThe site‐selective C−H amination of azines is a critical challenge due to the broad applications of amino azines in biologically important compounds. In this work, we report a conceptually novel approach to the electrophilic C2‐selective C−H amination of azines using O‐benzoylhydroxylamines, catalyzed by a benzyl–palladium complex. A key feature of this transformation is the formation of the distal C−N bond via a benzyl–Pd intermediate, facilitated by a malonate substituent on the azine as a remote directing group. This strategy effectively overrides the inherent polarity mismatch typically observed in electrophilic C2‐C−H aminations. The reaction exhibits high site‐selectivity and demonstrates towards amine‐sensitive functional group, highlighting its synthetic utility.
Predictive Value of Lung Ultrasound Combined With ACEF Score for the Prognosis of Acute Myocardial Infarction
Authors: Lun Ziheng , He Jiexin , Fu Ming , Yi Shixin , Dong Haojian , Zhang Ying 
Published: February 2025

ABSTRACTBackgroundLung ultrasound (LUS) and the ACEF score (age, creatinine, and ejection fraction) have been shown to be pivotal in predicting an unfavorable prognosis in acute myocardial infarction (AMI).HypothesisThe aim of this study is to investigate the prognostic value of LUS combined with ACEF score in AMI.MethodsThe ACEF score and the total number of B‐lines in eight thoracic regions of LUS were calculated. Adverse events were recorded during hospitalization and follow‐up, defined as all‐cause death and other cardiovascular events. Multivariate logistic regression identified predictors of adverse events during hospitalization. Multivariate Cox regression identified predictors of adverse events during follow‐up.ResultsWe enrolled 204 patients. The B‐lines (adjusted OR 1.08, [95% CI: 1.03–1.13], p < 0.01) and the ACEF score (adjusted OR 2.71 [95% CI: 1.07–6.81], p < 0.05) independently predicted adverse events during hospitalization. The C‐index values were 0.81 (p < 0.01) for the ACEF score, 0.81 (p < 0.01) for LUS, and 0.86 (p < 0.01) for their combination. One hundred seventy‐one patients were followed up for 12 months (IQR, 8.13–15.93). Both the B‐lines (adjusted HR 1.06 [95% CI: 1.03–1.09], p < 0.05) and the ACEF score (adjusted HR 1.95 [95% CI: 1.10–3.43], p < 0.05) remained associated with an increased risk of adverse events during follow‐up. The C‐index values were 0.74 (p < 0.01) for the ACEF score, 0.73 (p < 0.01) for LUS, and 0.80 (p < 0.01) for their combined predictive ability.ConclusionsThe B‐lines and ACEF score are associated with adverse events in AMI patients. When combined, they provide increasing value in assessing the risk of adverse events, which has significant implications for risk stratification.
Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy‐lysosome degradation of ACSL4
Authors: Zhu Xue‐Xue , Su Jia‐Bao , Wang Fang‐Ming , Chai Xiao‐Ying , Chen Guo , Xu An‐Jing , Meng Xin‐Yu , Qiu Hong‐Bo , Sun Qing‐Yi , Wang Yao , Lv Zhuo‐Lin , Zhang Yuan , Liu Yao , Han Zhi‐Jun , Li Na , Sun Hai‐Jian , Lu Qing‐Bo 
Published: February 2025

AbstractThe sodium pump Na+/K+‐ATPase (NKA), an enzyme ubiquitously expressed in various tissues and cells, is a critical player in maintaining cellular ion homeostasis. Dysregulation of α1 subunit of NKA (NKAα1) has been associated with cardiovascular and metabolic disorders, yet the exact role of NKAα1 in diabetes‐induced endothelial malfunction remains incompletely understood. The NKAα1 expression and NKA activity were examined in high‐glucose (HG)‐exposed endothelial cells (ECs) and mouse aortae, as well as in high‐fat‐diet (HFD)‐fed mice. Acetylcholine (Ach) was utilised to assess endothelium‐dependent relaxation (EDR) in isolated mouse aortae. We found that both NKAα1 protein and mRNA levels were significantly downregulated in the aortae of HFD‐fed mice, and HG‐incubated mouse aortae and ECs. Gain‐ and loss‐of‐function experiments revealed that NKAα1 preserves EDR by mitigating oxidative/nitrative stresses in ECs. Overexpression of NKAα1 facilitated EC viability, migration, and angiogenesis by inhibiting the overproduction of superoxide and peroxynitrite. Mechanistically, dysfunctional NKAα1 impaired autophagy process, and prevented the transfer of acyl‐CoA synthetase long‐chain family member 4 (ACSL4) to the lysosome for degradation, thereby resulting in lipid peroxidation and ferroptosis in ECs. Induction of ferroptosis and inhibition of the autophagy‐lysosome pathway blocked the protective effects of NKAα1 on EDR. Eventually, we identified Hamaudol as a potent activator of NKAα1 by restraining the phosphorylation and endocytosis of NKAα1, restoring EDR in obese diabetic mice. Overall, NKAα1 facilitates the autophagic degradation of ACSL4 via the lysosomal pathway, preventing ferroptosis and oxidative/nitrative stress in ECs. NKAα1 may serve as an attractive candidate for the management of vascular disorders associated with diabetes.Key points
NKAα1 downregulation impairs endothelial function in diabetes by promoting oxidative/nitrative stress and ferroptosis.
NKAα1 supports lysosomal degradation of ACSL4 via autophagy, preventing lipid peroxidation and ferroptosis.

Hamaudol, an activator of NKAα1, restores endothelial relaxation in diabetic mice by inhibiting NKAα1 phosphorylation and endocytosis.
Use of a short educational video to improve the accuracy of colorectal polyp morphology assessment: A multicenter randomized controlled study
Authors: Utsumi Takahiro , Horimatsu Takahiro , Nishikawa Yoshitaka , Teramoto Akira , Hirata Daizen , Iwatate Mineo , Tanaka Shinwa , Ikezawa Nobuaki , Esaki Masaya , Osera Shozo , Ebisutani Chikara , Saito Hiroaki , Agatsuma Nobukazu , Hiramatasu Yukiko , Nakanishi Yuki , Sano Yasushi , Seno Hiroshi 
Published: February 2025

AbstractObjectivesAlthough accurate assessment of polyp morphology helps endoscopists select the appropriate management for colorectal polyps, some studies have reported unsatisfactory accuracy in such assessment. This study aimed to clarify the usefulness of a short educational video available on the Internet for accurate polyp morphology assessment.MethodsThis was a multicenter randomized controlled trial. Participants were randomly assigned to the pre‐ or post‐education groups after a pre‐test comprising images of 42 polyps, including 12 laterally spreading tumors. Participants who scored ≥ 80% on the pre‐test were excluded. Only the post‐education group completed the diagnostic test after watching an online educational video. The primary outcome was the difference in diagnostic accuracy between the pre‐test and diagnostic tests for each group.ResultsOf the 296 endoscopists enrolled from 48 institutions, 34 missed the test deadline, and 29 who scored ≥ 80% in the pre‐test were excluded. The primary outcome analysis sets were 117 and 116 in the pre‐ and post‐education groups, respectively. The mean pre‐test accuracies in the pre‐education and post‐education groups were 60.6% and 60.7%, respectively. The difference in diagnostic accuracy between the pre‐test and diagnostic test was significantly higher in the post‐education than the pre‐education group (12.0 points, 95% confidence interval [CI] 9.9–14.1 and 2.3 points, 95% CI 0.9–3.6; p < 0.001).ConclusionThis multicenter randomized controlled trial demonstrated the usefulness of a short educational video for accurate polyp morphology assessment.