bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cost-Effectiveness of Early High-Acuity Postoperative Care for Medium-Risk Surgical Patients
Authors: Leaman Esrom E. , Ludbrook Guy L. 
Published: November 2023

BACKGROUND:
Initiatives in perioperative care warrant robust cost-effectiveness analysis in a cost-constrained era when high-value care is a priority. A model of anesthesia-led early high-acuity postoperative care, advanced recovery room care (ARRC), has shown benefit in terms of hospital and patient outcomes, but its cost-effectiveness has not yet been formally determined.

METHODS:
Data from a previously published single-center prospective cohort study of ARRC in medium-risk patients were used to generate a Markov model, which described patient transition between care locations, each with different characteristics and costs. The incremental cost-effectiveness ratio (ICER), using days at home (DAH) and hospital costs, was calculated for ARRC compared to usual ward care using deterministic and probabilistic sensitivity analysis.

RESULTS:
The Markov model accurately described patient disposition after surgery. For each patient, ARRC provided 4.3 more DAH within the first 90 days after surgery and decreased overall hospital costs by $1081 per patient. Probabilistic sensitivity analysis revealed that ARRC had a 99.3% probability of increased DAH and a 77.4% probability that ARRC was dominant from the perspective of the hospital, with improved outcomes and decreased costs.

CONCLUSIONS:
Early high-acuity care for approximately 24 hours after surgery in medium-risk patients provides highly cost-effective improvements in outcomes when compared to usual ward care.
Association Between Loop Diuretics and Mortality in Patients With Cardiac Surgery–Associated Acute Kidney Injury: A Retrospective Propensity Score–Weighted Analysis
Authors: Zhu Shouqiang , Zheng Ziyu , Wang Lini , Luo Gang , Zhang Yue , Jia Tao , Wang Yi , Dong Hailong , Lei Chong 
Published: November 2023

BACKGROUND:
Although loop diuretics (LDs) have been widely used in clinical practice, their effect on mortality when administered to patients experiencing cardiac surgery–associated acute kidney injury (CS-AKI) remains unknown. The study aimed to investigate the effectiveness of LD use in patients with CS-AKI.

METHODS:
Patients who underwent cardiac surgery with AKI were identified from the Medical Information Mart for Intensive Care III. Postoperative LD use in intensive care units (ICUs) was exposure. There were 2 primary outcome measures, the in-hospital mortality and ICU mortality; both were treated as time-to-event data and were analyzed via multivariable Cox proportional hazard models. Inverse probability weighting (IPW) was used to minimize bias.

RESULTS:
The study enrolled a total of 5478 patients, with a median age of 67 years, among which 2205 (40.3%) were women. The crude in-hospital and ICU mortality rates were significantly lower in the LD use group (525 of 4150 [12.7%] vs 434 of 1328 [32.7%], P < .001; 402 of 4150 [9.69%] vs 333 of 1328 [25.1%], P < .001). Adjusted hazard ratios suggested significant reductions in both in-hospital (hazard ratio [HR], 0.428; 95% confidence interval [CI], 0.374–0.489) and ICU mortality (HR, 0.278; 95% CI, 0.238–0.327). The IPW data showed a similar reduction, in-hospital mortality (HR, 0.434; 95% CI, 0.376–0.502) and ICU mortality (HR, 0.296; 95% CI, 0.251–0.349). Such association may act differently for patients with different fluid balance (P value for interaction < .001).

CONCLUSIONS:
LD use is associated with lower hospital and ICU mortality in CS-AKI patients in general. Patients under different conditions showed diverse responses toward such treatment indicating that personalized management is needed.
Evaluating the Accuracy of 2020 Census Block-Level Estimates in California
Authors: Bozick Robert , Burgette Lane F. , Sharygin Ethan , Shih Regina A. , Weidmer Beverly , Tzen Michael , Kofner Aaron , Brand Jennie E. , Beltrán-Sánchez Hiram 
Published: November 2023

Abstract
In this study, we provide an assessment of data accuracy from the 2020 Census. We compare block-level population totals from a sample of 173 census blocks in California across three sources: (1) the 2020 Census, which has been infused with error to protect respondent confidentiality; (2) the California Neighborhoods Count, the first independent enumeration survey of census blocks; and (3) projections based on the 2010 Census and subsequent American Community Surveys. We find that, on average, total population counts provided by the U.S. Census Bureau at the block level for the 2020 Census are not biased in any consistent direction. However, subpopulation totals defined by age, race, and ethnicity are highly variable. Additionally, we find that inconsistencies across the three sources are amplified in large blocks defined in terms of land area or by total housing units, blocks in suburban areas, and blocks that lack broadband access.
Inter-organ communication during tissue regeneration
Authors: Sun Fei , Poss Kenneth D. 
Published: November 2023

ABSTRACT
Tissue regeneration is not simply a local repair event occurring in isolation from the distant, uninjured parts of the body. Rather, evidence indicates that regeneration is a whole-animal process involving coordinated interactions between different organ systems. Here, we review recent studies that reveal how remote uninjured tissues and organ systems respond to and engage in regeneration. We also discuss the need for toolkits and technological advancements to uncover and dissect organ communication during regeneration.
Antimicrobial effects of botanicals and biocontrol agents against Phaeoisariopsis personata, the causal agent of Tikka disease of groundnut
Authors: NDIFON ELIAS MJAIKA 
Published: November 2023

Abstract. Ndifon EM. 2023. Antimicrobial effects of botanicals and biocontrol agents against Phaeoisariopsis personata, the causal agent of Tikka disease of groundnut. Asian J Agric 7: 71-75. Groundnut is highly susceptible to various pathogenic diseases, the most important of these is tikka. The aim of this study was to control the infection of groundnut caused by Phaeoisariopsis personata (Berk. & M.A.Curtis) Arx using two experiments. Each trial was set up using a completely randomized design, and each treatment was replicated thrice. Results show that Eucalyptus globulus Labill. resinous gum (at 50% and 100% concentrations) and Terminalia catappa L. resinous gum (at 50% concentration) were more effective in the inhibition of P. personata, followed by Anacardium officinale Pritz. resinous gum and T. catappa resinous gum (at 100% concentration). All the plant extracts significantly (P?0.05) inhibited the pathogen. The percentage inhibition of P. personata by plant extracts ranged between 7.9-100%. All the isolates of Trichoderma were able to inhibit P. personata effectively, but the percentage inhibition of mycelial growth of P. personata reduced gradually with time. The percentage inhibition of P. personata by Trichoderma species ranged between 24-100%. The best biocontrol treatments were T. virens isolate BGMZ2, T. harzianum isolate BGMZ4, T. hamatum isolate ZXPB, and T. harzianum isolate ZXMZ. Using these biocontrol and botanical measures to manage the tikka leaf spot of groundnut is highly recommended.
Colonization with extended spectrum beta-lactamase and carbapenemases producing Enterobacteriaceae among hospitalized patients at the global level: A systematic review and meta-analysis
Authors: Abera Dessie , Alemu Ayinalem , Mihret Adane , Negash Abel Abera , Abegaz Woldaregay Erku , Cadwell Ken 
Published: November 2023

Background
Gut commensal bacteria can mediate resistance against pathogenic bacteria. However, exposure to antibiotics and hospitalization may facilitate the emergence of multidrug resistant bacteria. We aimed to conduct a systematic review and meta-analysis to provide comprehensive evidence about colonization rate of extended spectrum beta-lactamase and carbapenemases producing Enterobacteriaceae.

Method
We used PubMed, Google Scholar and Web of Science data bases to search studies from January 1, 2016 to August10, 2022 about colonization rate of extended spectrum beta-lactamase and carbapenemase producing Enterobacteriaceae. Data were extracted from eligible studies and analyzed using Stata version 16 software. The quality of included studies was assessed using the Joanna Briggs Institute Critical Appraisal tools, and publication bias was assessed using funnel plot and eggers test.

Results
We identified 342 studies from the comprehensive data search and data were extracted from 20 studies. The pooled estimate of extended spectrum beta-lactamase and carbapenemase producing Enterobacteriaceae were 45.6%(95%CI: 34.11-57-10) and 16.19% (95% CI: 5.46–26.91) respectively. The predominant extended spectrum beta-lactamase producers were E. coli,32.99% (95% CI: 23.28–42.69) and K. pneumoniae, 11.43% (95% CI:7.98–14.89). Prolonged hospitalization was linked to carbapenemase producing Enterobacteriaceae colonization with the odds of 14.77 (95% CI: -1.35–30.90) at admission and 45.63 (95% CI: 0.86–92.12) after ≥7 days of admission.

Conclusion
The pooled estimate of extended spectrum beta-lactamase and carbapenemase producing Enterobacteriaceae were high. This indicates the need for strong mitigation strategies to minimize the spread of multidrug-resistant bacteria at the healthcare facilities.
Cost-effectiveness of internet-based HIV screening among gay, bisexual and other men who have sex with men (GBMSM) in Metro Vancouver, Canada
Authors: De Anda Jose A. , Irvine Michael A. , Zhang Wei , Salway Travis , Haag Devon , Gilbert Mark 
Published: November 2023

BackgroundGetCheckedOnline is an internet-based screening service aiming to increase HIV testing among gay, bisexual and other men who have sex with men (GBMSM). We assessed the cost-effectiveness of GetCheckedOnline in its first implementation phase at different uptake scenarios compared to clinic-based screening services alone in Metro Vancouver, Canada.MethodsFrom a healthcare payer’s perspective, our cost-utility analysis used an established dynamic GBMSM HIV compartmental model estimating the probability of acquiring HIV, progressing through diagnosis, disease stages and treatment over a 30-year time horizon. The base case scenario assumed 4.7% uptake of GetCheckedOnline in 2016 (remainder using clinic-based services), with 74% of high-risk and 44% of low-risk infrequent testers becoming regular testers in five years. Scenario analyses tested increased GetCheckedOnline uptake to 10% and 15%.ResultsThe cost per test for GetCheckedOnline was $29.40 compared to clinic-based services $56.92. Compared with clinic-based screening services, the projected increase in testing frequency with 4.7% uptake of GetCheckedOnline increased the costs by $329,600 (95% Credible Interval: -$498,200, $571,000) and gained 4.53 (95%CrI: 0, 9.20) quality-adjusted life years (QALYs) in a 30-year time horizon. The probability of GetCheckedOnline being cost-effective was 34% at the threshold of $50,000 per QALY, and increased to 73% at the threshold of $100,000 per QALY. The results were consistent in the other uptake scenarios. The probability of GetCheckedOnline being cost-effective became 80% at the threshold of $50,000 per QALY if assuming 5-year time horizon.ConclusionsGetCheckedOnline is almost half the cost of clinic-based services on a per-test basis. However, increased access to testing should be balanced with risk profiles of patients to ensure the implementation can be a cost-effective strategy for increasing HIV screening among GBMSM in Metro Vancouver. Additional analyses are needed to understand the impact of internet-based screening including screening for other STIs and in other populations.
Techno-Economic Analysis of Solar Absorption Cooling for Commercial Buildings in India
Authors: Narayanan Muthalagappan 
Published: November 2023

Space cooling and heating always tends to be a major part of the primary energy usage. By using fossil fuel electricity for these purposes, the situation becomes even worse. One of the major electricity consumptions in India is air conditioning. There are a lot of different technologies and few researchers have come up with a debate between solar absorption cooling and PV electric cooling. In a previous paper, PV electric cooling was studied and now as a continuation, this paper focuses on solar thermal absorption cooling systems and their application in commercial/office buildings in India. A typical Indian commercial building is taken for the simulation in TRNSYS. Through this simulation, the feasibility and operational strategy of the system is analysed, after which parametric study and economic analysis of the system is done. When compared with the expenses for a traditional air conditioner unit, this solar absorption cooling will take 13.6 years to pay back and will take 15.5 years to payback the price of itself and there after all the extra money are savings or profit. Although the place chosen for this study is one of the typical tropical place in India, this payback might vary with different places, climate and the cooling demand.Article History: Received May 12th 2017; Received in revised form August 15th 2017; Accepted 1st Sept 2017; Available onlineHow to Cite This Article: Narayanan, M. (2017). Techno-Economic Analysis of Solar Absorption Cooling for Commercial Buildings in India. International Journal of Renewable Energy Development, 6(3), 253-262.https://doi.org/10.14710/ijred.6.3.253-262
Valuasi Ekonomi Nilai Manfaat Langsung Waduk Sermo, Kabupaten Kulon Progo, Yogyakarta
Authors: Liana Tri Budi , Purwanti Frida , Sulardiono Bambang 
Published: November 2023

Waduk Sermo merupakan salah satu waduk di Kabupaten Kulon Progo, yang dimanfaatkan sebagai tempat pariwisata, sumber air bersih dan perikanan tangkap. Valuasi ekonomi dari berbagai pemanfaatan tersebut perlu dilakukan sebagai dasar upaya pengelolaan karena belum terukur secara ekonomi. Tujuan penelitian ini adalah untuk mengetahui nilai ekonomi dari pemanfaatan Waduk Sermo sehingga dapat digunakan untuk penentuan kebijakan pengelolaan waduk. Penelitian ini dilaksanakan pada tanggal 14 Februari sampai 14 Maret 2022 di Waduk Sermo, Desa Hargowilis, Kecamatan Kokap, Kabupaten Kulon Progo. Metode penentuan jumlah responden menggunakan convenience sampling untuk pariwisata dan pemancing dengan jumlah responden masing-masing 50 orang, random sampling untuk masyarakat pengguna air bersih dengan jumlah responden yaitu 43 orang, serta sensus dengan meneliti semua nelayan Waduk Sermo yaitu 34 orang. Metode Analisis data yang digunakan dalam penelitian ini yaitu Travel Cost Method untuk pemanfaatan pariwisata, Contingen Valuation Method air bersih, dan Market Price Method untuk perikanan tangkap. Hasil penelitian didapatkan Valuasi Ekonomi yaitu Pariwisata Rp. 8.560.697.600/tahun, Air Bersih Rp. 1.241.141.023/tahun serta Perikanan Tangkap Rp. 4.406.047.935/tahun yang diperoleh dari nelayan Rp. 4.364.989.545/tahun dan dari pemancing Rp. 41.058.390/tahun.
Hauptsätze mit Verbspäterstellung im Althochdeutschen: Bestand, Distribution, Interpretation
Authors: Petrova Svetlana 
Published: November 2023

Abstract
This corpus study investigates well-known violations of the verb second constraint in Old High German main clauses. Starting from the observation that the attested orders are overwhelmingly ambiguous regarding the position of the verb and the preverbal constituents, the paper applies methods for identifying diagnostic datasets which can be clearly distinguished in terms of structure and use. Two types of diagnostic non-verb-second orders are tested, namely verb-final clauses in which no verb movement applies, and verb-third clauses in which the verb as well as all preverbal categories occupy specified positions in the left periphery of the clause. The result is that diagnostic evidence for any of the datasets is sparse in native prose, and that especially diagnostic verb-third orders are not sufficiently distinguishable against their Latin originals. In addition, both diagnostic patterns interfere in use, suggesting that they represent less clearly differentiated, unproductive patterns, used for special stylistic purposes.
A User’s Defense of the Tolerance Principle: Reply to Enger (2022)
Authors: Yang Charles 
Published: November 2023

Abstract
I provide an overview of the Tolerance Principle, its motivation, supporting evidence, and applications, with particular focus on how it can be used recursively to discover linguistic regularities of varying scopes. It corrects the misunderstandings in Enger’s recent article but the more important goal is to provide rigorously formulated predictions and quantitative data to the structural analysis of language.
Minnesang trifft Pijjut und Midrasch
Authors: Hon Jan K. 
Published: November 2023

Abstract
The essay examines the fourteenth-century Yiddish poem ›Yosef Ha-Tsadik‹ about Joseph and Potipharʼs wife. The poem, presented here in a new critical edition, is primarily based on Hebrew and Aramaic midrashic and liturgical sources but also incorporates elements derived from German courtly love poetry, mainly to express Potipharʼs wifeʼs advances toward Joseph. It can thus be read as a Jewish dialogue with Christian secular literary traditions. Drawing on a comparison with the Jewish pretexts – some of which are presented here for the first time in German translations – and a number of examples from Minnesang, the study analyzes the strategies of both participation in and (ironic) distancing from the Christian courtly discourse.
A novel LC-MS/MS-based assay for the simultaneous quantification of aldosterone-related steroids in human urine
Authors: Vogg Nora , Kürzinger Lydia , Kendl Sabine , Pamporaki Christina , Eisenhofer Graeme , Adolf Christian , Hahner Stefanie , Fassnacht Martin , Kurlbaum Max 
Published: November 2023

Abstract

Objectives
Primary aldosteronism is the most common cause of endocrine hypertension and is associated with significant cardiovascular morbidities. The diagnostic workup depends on determinations of plasma aldosterone and renin which are highly variable and associated with false-positive and false-negative results. Quantification of aldosterone in 24 h urine may provide more reliable results, but the methodology is not well established. We aimed to establish an assay for urinary aldosterone and related steroids with suitability for clinical routine implementation.

Methods
Here, we report on the development and validation of a quantitative LC-MS/MS method for six urinary steroids: aldosterone, cortisol, 18-hydroxycorticosterone, 18-hydroxycortisol, 18-oxocortisol, tetrahydroaldosterone. After enzymatic deconjugation, total steroids were extracted using SepPak tC18 plates and quantified in positive electrospray ionization mode on a QTRAP 6500+ mass spectrometer.

Results
Excellent linearity was demonstrated with R2>0.998 for all analytes. Extraction recoveries were 89.8–98.4 % and intra- and inter-day coefficients of variations were <6.4 and <9.0 %, establishing superb precision. Patients with primary aldosteronism (n=10) had higher mean 24 h excretions of aldosterone-related metabolites than normotensive volunteers (n=20): 3.91 (95 % CI 2.27–5.55) vs. 1.92 (1.16–2.68) µmol/mol for aldosterone/creatinine, 2.57 (1.49–3.66) vs. 0.79 (0.48–1.10) µmol/mol for 18-hydroxycorticosterone/creatinine, 37.4 (13.59–61.2) vs. 11.61 (10.24–12.98) µmol/mol for 18-hydroxycortisol/creatinine, 1.56 (0.34–2.78) vs. 0.13 (0.09–0.17) µmol/mol for 18-oxocortisol/creatinine, and 21.5 (13.4–29.6) vs. 7.21 (4.88–9.54) µmol/mol for tetrahydroaldosterone/creatinine.

Conclusions
The reported assay is robust and suitable for routine clinical use. First results in patient samples, though promising, require clinical validation in a larger sample set.
Geochemical evaluation of the carbonaceous shale associated with the Permian Mikambeni Formation of the Tuli Basin for potential gas generation, South Africa
Authors: Akintola George Oluwole 
Published: November 2023

Abstract
The increasing demand for energy and global commitment to reduce CO2 emissions to mitigate climate change has spurred countries to pursue unconventional hydrocarbon generation for power production. The investigation of the carbonaceous shale from the Permian Mikambeni Formation of the Tuli Basin in South Africa aims to assess the potential for gas generation. The Rock-Eval 6 pyrolysis of the studied samples shows total organic carbon (TOC) content ranging from 10.10 to 37.61 wt%, indicating an excellent source rock quality since it exceeds the threshold limit of 5 wt%. The produced gas that emanated from the thermal breakup of remaining hydrocarbon (S2) ranged from 14.30 to 65.55 mg HC/g rock while the hydrogen index (HI) ranged from 56.55 to 198.22 mg/g TOC. The plot of the HI against T
max indicates the predominance of type-III kerogen, prone to gas generation. The thermal maturity parameters, T
max (430–466°C), and vitrinite reflectance, VRo (0.6–1.2), showed a matured organic material. The production index value (0.06) of the samples indicates a moderately mature source generating a biogenic gas. The carbon isotopic composition, δ
13C (−20.0 to −23.4‰), indicates a predominant influx of organic matter derived from a vascular higher plant. The studied samples showed relatively depleted values of oxygen isotopic composition δ
16O (14.1–18.8‰), suggesting a brackish water depositional environment. Additionally, the Ba concentration (303.15–331.27 ppm) exceeds the 200 ppm threshold for the marine environment, indicating a non-marine environment characterised by low marine paleo-productivity and high detrital influx. Based on the evaluation, the studied coaly-shale is found with a matured and type-III kerogen that is prone to gas generation in a fluvial, paleo-depositional environment.
Bayesian second-order sensitivity of longitudinal inferences to non-ignorability: an application to antidepressant clinical trial data
Authors: Momeni Roochi Elahe , Eftekhari Mahabadi Samaneh 
Published: November 2023

Abstract
Incomplete data is a prevalent complication in longitudinal studies due to individuals’ drop-out before intended completion time. Currently available methods via commercial software for analyzing incomplete longitudinal data at best rely on the ignorability of the drop-outs. If the underlying missing mechanism was non-ignorable, potential bias arises in the statistical inferences. To remove the bias when the drop-out is non-ignorable, joint complete-data and drop-out models have been proposed which involve computational difficulties and untestable assumptions. Since the critical ignorability assumption is unverifiable based on the observed part of the sample, some local sensitivity indices have been proposed in the literature. Specifically, Eftekhari Mahabadi (Second-order local sensitivity to non-ignorability in Bayesian inferences. Stat Med 2018;59:55–95) proposed a second-order local sensitivity tool for Bayesian analysis of cross-sectional studies and show its better performance for handling bias compared with the first-order ones. In this paper, we aim to extend this index for the Bayesian sensitivity analysis of normal longitudinal studies with drop-outs. The index is driven based on a selection model for the drop-out mechanism and a Bayesian linear mixed-effect complete-data model. The presented formulas are calculated using the posterior estimation and draws from the simpler ignorable model. The method is illustrated via some simulation studies and sensitivity analysis of a real antidepressant clinical trial data. Overall, the numerical analysis showed that when repeated outcomes are subject to missingness, regression coefficient estimates are nearly approximated well by a linear function in the neighbourhood of MAR model, but there are a considerable amount of second-order sensitivity for the error term and random effect variances in Bayesian linear mixed-effect model framework.