bluuebunny/crossref_metadata_2025_split huggingface dataset:
An organizing framework to break down Western-centric views of knowledge in North–South research
Authors: Turner Hannah , Rogers Briony , Kneebone Sarah , Ramirez Diego , French Matthew , Sawailau Mere Jane , Volavola Filise , Baran Sholyn , Matavesi Kelera , Newton Orlando , Luveniyali Maraia Batiota , Tela Autiko , Vakarewa Isoa 
Published: February 2024

AbstractGlobal challenges, such as climate change, persistent poverty, and food insecurity are complex problems. These societal, environmental, and economic challenges cross scientific disciplines, communities, and geographies, requiring interdisciplinary, North–South solutions. Nevertheless, prevailing sustainability science responses are Western-centric. Some seminal studies have attempted to understand and engage with diverse knowledge systems. These include decolonial and Indigenous methodologies, such as “Two-Eyed Seeing”, which emphasizes the importance of using both Western and Indigenous knowledge to gain a more comprehensive understanding of the world, and participatory action research, which highlights the importance of involving participants in the research process and promoting social change through collaborative effort. However, apart from in-country research collaborations with traditional Indigenous knowledge, most North–South studies overlook the role or influence of Western-centric views and therefore fail to recognize and incorporate diverse worldviews and knowledge systems. This may, in part, reflect the tendency to categorize research into disciplinary silos, but more likely is the unintentional, yet prevalent, view that Western science is “objective and neutral.” As more scholars from multiple disciplines and geographies focus on interdisciplinary North–South research, it is critical that researchers reflect on dominant research approaches and knowledge production. Studies can co-construct, reproduce, or control the forms of knowledge generated—whether intentional or unintentional. This paper presents an organizing framework to help researchers navigate, understand, and engage with diverse forms of knowledge in undertaking North–South research. The framework draws on empirical observations from the authors’ interdisciplinary research and from empirical cross-cultural literature. It comprises three contextual levels of influence, featuring guiding principles and subsequent practical actions researchers can use to navigate the complexities of knowledge co-construction in North–South research.
Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study
Authors: Semerci Sevimli Tuğba , Ghorbani Aynaz , Demir Cevizlidere Bahar , Altuğ Burcugül , Sevimli Murat 
Published: February 2024

AbstractDNA double-strand break (DSB) repair genes interact with tumor stemness- and resistance-associated processes in cancer stem cells (CSCs). Therefore, targeting DNA DSB genes in cancer treatment is important for the CSC phenotype. Although the anti-cancer effect of boric acid (BA) has been studied, its effect on DNA DSB is unclear. Moreover, no studies investigate BA’s effects on DNA DSB of lung cancer stem cells (LC-SCs). To fill the gap, we aimed to assess the effects of BA on A549 cancer stem cells. CSCs were isolated from human non-small cell lung cancer cells (A549) and characterized by flow cytometry. Different concentrations of BA (at doses ranging from 1 to 100 mM) were applied to cancer stem cells. Cytotoxic activities were determined using the cell viability assay (MTT assay) at 24 and 48 h. Expression levels of DNA DSB genes that BRCA1, BRCA2, RAD51, KU70/80, ATM, and XRCC4 were evaluated by RT-qPCR. Additionally, immunofluorescence staining analysis was exploited for caspase-3 and E-cadherin. ATM expression increased significantly (p < 0.001). No significant change was observed in the expression of other genes. Moreover, BA up-regulated caspase-3 and E-cadherin expression. Consequently, we can say that BA affects DNA DSB and the apoptotic abilities of LC-SCs.
Graphical Abstract
Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes
Authors: Li Haiyan , Zhang Haowei , Wang Tongling , Zhang Liyuan , Wang Hao , Lu Heng , Yang Ruirui , Ding Yusong 
Published: February 2024

AbstractPancreatic β cell damage is the primary contributor to type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains nebulous. This study explored the role of ferroptosis in pancreatic β cell damage and the protective effects of grape seed proanthocyanidin extract (GSPE). In T2DM model rats, the blood glucose, water intake, urine volume, HbA1c, and homeostasis model assessment-insulin resistance were significantly increased, while the body weight and the insulin level were significantly decreased, indicating the successful establishment of the T2DM model. MIN6 mouse insulinoma β cells were cultured in high glucose and sodium palmitate conditions to obtain a glycolipid damage model, which was administered with GSPE, ferrostatin-1 (Fer-1), or nuclear factor erythroid 2-related factor 2 (Nrf2) small interfering (si) RNA. GSPE and Fer-1 treatment significantly improved pancreatic β-cell dysfunction and protected against cell death. Both treatments increased the superoxide dismutase and glutathione activity, reduced the malondialdehyde and reactive oxygen species levels, and improved iron metabolism. Furthermore, the treatments reversed the expression of ferroptosis markers cysteine/glutamate transporter (XCT) and glutathione peroxidase 4 (GPX4) caused by glycolipid toxicity. GSPE treatments activated the expression of Nrf2 and related proteins. These effects were reversed when co-transfected with si-Nrf2. GSPE inhibits ferroptosis by activating the Nrf2 signaling pathway, thus reducing β-cell damage and dysfunction in T2DM. Therefore, GSPE is a potential treatment strategy against T2DM.
Graphical Abstract
Construction and validation of a nomogram for predicting lateral lymph node metastasis in pediatric and adolescent with differentiated thyroid carcinoma
Authors: Dan Jiaqiang , Tan Jingya , Guo Yao , Xu Yang , Zhou Lin , Huang Junhua , Yuan Zhiying , Ai Xiang , Li Junyan 
Published: February 2024

Abstract
Background
Limited research has been conducted to specifically investigate the identification of risk factors and the development of prediction models for lateral lymph node metastasis (LNM) in pediatric and adolescent differentiated thyroid carcinoma (DTC) populations, despite its significant association with unfavorable prognosis.

Methods
This study entails a retrospective analysis of the clinical characteristics exhibited by pediatric and adolescent patients who have been diagnosed with DTC. The data utilized for this analysis was sourced from the Surveillance, Epidemiology, and End Results (SEER) database, spanning the time frame from 2000 to 2020. Furthermore, the study incorporates patients who were treated at the Departments of Breast and Thyroid Surgery in the Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine, as well as The General Hospital of Western Theater Command, during the period from 2010 to 2020.

Results
A cohort of 2631 patients from the SEER database, along with an additional 339 patients from our departments who met the specified inclusion criteria, were included in this study. Subsequently, four clinical variables, namely age, tumor size, multifocality, and extrathyroidal invasion, were identified as being significantly associated with lateral LNM in pediatric and adolescent DTC patients. These variables were then utilized to construct a nomogram, which demonstrated effective discrimination with a concordance index (C-index) of 0.731. Furthermore, the performance of this model was validated through both internal and external assessments, yielding C-index values of 0.721 and 0.712, respectively. Afterward, a decision curve analysis was conducted to assess the viability of this nomogram in predicting lymph node metastasis.

Conclusion
The current investigation has effectively constructed a nomogram model utilizing visualized multipopulationsal data. Our findings demonstrate a significant association between various clinical characteristics and lateral LNM in pediatric and adolescent DTC patients. These outcomes hold substantial significance for healthcare practitioners, as they can employ this model to inform individualized clinical judgments for the pediatric and adolescent cohorts.
Downregulating DNA methyltransferase 3B by suppressing the PI3K/Akt signaling pathway enhances the chemosensitivity of glioblastoma to temozolomide
Authors: Kan Wenwu , Gao Linhui , Chen Jingnan , Chen Li , Zhang Guojun , Hao Bilie , He Min , Chen Xudong , Wang Cheng 
Published: February 2024

AbstractGlioblastoma (GBM) is the most common malignant brain tumor and has the poorest prognosis attributed to its chemoresistance to temozolomide (TMZ), the first-line drug for treating GBM. TMZ resistance represents a significant obstacle to successful GBM treatment, necessitating the development of new strategies to overcome this resistance and augment the chemosensitivity of GBM cells to TMZ. This study established a TMZ-resistant U251 (U251-TMZ) cell line by exposing it to increasing doses of TMZ in vitro. We focused on the DNA methyltransferase 3B (DNMT3B) gene, phosphorylated Akt (p-Akt), total Akt (t-Akt), phosphorylated PI3K (p-PI3K), and total PI3K (t-PI3K) protein expression. Results showed that the DNMT3B gene was significantly upregulated in the U251-TMZ cell line. The p-Akt and p-PI3K protein expression in U251-TMZ cells was also significantly elevated. Moreover, we found that DNMT3B downregulation was correlated with the increased chemosensitivity of GBM cells to TMZ. LY294002 suppressed the PI3K/Akt signaling pathway, leading to a notable inhibition of PI3K phosphorylation and a significant decrease in DNMT3B expression in U251-TMZ cells. Given that DNMT3B expression is mediated by the PI3K/Akt signaling pathway, its downregulation further increased the chemosensitivity of GBM cells to TMZ and therefore is a promising therapeutic for GBM treatment. Our results suggested that DNMT3B downregulation can inhibit the proliferation of GBM cells and induce GBM cell apoptosis in vitro. In addition, the PI3K/Akt signaling pathway plays an important role in the chemosensitivity of GBM cells to TMZ by regulating DNMT3B expression.
Neighbourhood Health Inequalities between Ethnic Groups in England: An Application of Ecological Inference
Authors: Congdon Peter 
Published: February 2024

AbstractEcological inference has had primarily political science applications, but this study considers an application to assess variations in neighbourhood mental health between population sub-groups. The methodology used has particular utility when neighbourhood health data are available only in aggregate form, without disaggregation (e.g. by ethnic or socioeconomic group). The ecological inference approach is shown to provide insights into contextual effects, where neighbourhood features influence disease variations between sub-groups (e.g. the ethnic density effect on psychosis among non-white groups). The present study also highlights important issues raised by the data’s geographic framework, namely strong spatial clustering in the outcome, and compares spatial error and spatial lag methods to represent this spatial patterning appropriately. The study considers neighbourhood variations in psychosis between four ethnic groups, with a spatial framework provided by 32,844 small areas (Lower Super Output Areas, LSOAs) in England.
Guilt over success, impostor phenomenon, and self-sabotaging behaviors
Authors: Fimiani Ramona , Mannocchi Camilla , Gorman Bernard S. , Gazzillo Francesco 
Published: February 2024

AbstractImpostor phenomenon refers to the psychological feeling of intellectual phoniness. It can favor failures and support a scarce perception of one’s own competence in order to protect social relations. The aim of this study was to investigate, with a longitudinal design, the contribution of fear of success and guilt over success in the experience of impostor phenomenon and its connections to maladaptive behaviors, such as submission and self-handicapping tendency. We assumed that impostor phenomenon would mediate the relationship between fear of success, guilt over success, and distress related to it, on one hand, and self-handicapping and submissive behavior on the other. Moreover, several personality variables were tested as potential predictors and protection factors against impostor phenomenon. As expected, we found a positive relationship between fear of success, guilt over success, and impostor phenomenon, and a positive relationship between impostor phenomenon and a tendency toward submitting and self-handicapping. Our findings suggest that the tendency to experience guilt and distress about success and the preoccupation with the impact of one’s own success on our important relationship predicted, both directly and with the mediation of impostor phenomenon, the tendency to submit and self-handicap.
Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
Authors: Tao Yue , Luo Cheng-Juan , Zhang Bing-Hua , Shen Xin-Yan , Zhao Rui-Ke , Ma Bei-Ying , Shen Nan , Luo Chang-Ying , Wang Jian-Min , Xia Yi-Jun , Xie Li , Chen Jing , Mo Xi 
Published: February 2024

Abstract
Background
Diarrhea is a common complication of hematopoietic stem cell transplantation (HSCT) and is associated with substantial morbidity, but its etiology is often unknown. Etiologies of diarrhea in this population include infectious causes, chemotherapy- or medication-induced mucosal injury and graft-versus-host disease (GVHD). Distinguishing these potential causes of diarrhea is challenging since diarrheal symptoms are often multifactorial, and the etiologies often overlap in transplant patients. The objectives of this study were to evaluate whether the FilmArray gastrointestinal (GI) panel would increase diagnostic yield and the degree to which pre-transplantation colonization predicts post-transplantation infection.

Methods
From November 2019 to February 2021, a total of 158 patients undergoing HSCT were prospectively included in the study. Stool specimens were obtained from all HSCT recipients prior to conditioning therapy, 28 ± 7 days after transplantation and at any new episode of diarrhea. All stool samples were tested by the FilmArray GI panel and other clinical microbiological assays.

Results
The primary cause of post-transplantation diarrhea was infection (57/84, 67.86%), followed by medication (38/84, 45.24%) and GVHD (21/84, 25.00%). Ninety-five of 158 patients were colonized with at least one gastrointestinal pathogen before conditioning therapy, and the incidence of infectious diarrhea was significantly higher in colonized patients (47/95, 49.47%) than in non-colonized patients (10/63, 15.87%) (P < 0.001). Fourteen of 19 (73.68%) patients who were initially colonized with norovirus pre-transplantation developed a post-transplantation norovirus infection. Twenty-four of 62 (38.71%) patients colonized with Clostridium difficile developed a diarrheal infection. In addition, FilmArray GI panel testing improved the diagnostic yield by almost twofold in our study (55/92, 59.78% vs. 30/92, 32.61%).

Conclusions
Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.

Graphical abstract
TB-CXRNet: Tuberculosis and Drug-Resistant Tuberculosis Detection Technique Using Chest X-ray Images
Authors: Rahman Tawsifur , Khandakar Amith , Rahman Ashiqur , Zughaier Susu M. , Al Maslamani Muna , Chowdhury Moajjem Hossain , Tahir Anas M. , Hossain Md. Sakib Abrar , Chowdhury Muhammad E. H. 
Published: February 2024

AbstractTuberculosis (TB) is a chronic infectious lung disease, which caused the death of about 1.5 million people in 2020 alone. Therefore, it is important to detect TB accurately at an early stage to prevent the infection and associated deaths. Chest X-ray (CXR) is the most popularly used method for TB diagnosis. However, it is difficult to identify TB from CXR images in the early stage, which leads to time-consuming and expensive treatments. Moreover, due to the increase of drug-resistant tuberculosis, the disease becomes more challenging in recent years. In this work, a novel deep learning-based framework is proposed to reliably and automatically distinguish TB, non-TB (other lung infections), and healthy patients using a dataset of 40,000 CXR images. Moreover, a stacking machine learning-based diagnosis of drug-resistant TB using 3037 CXR images of TB patients is implemented. The largest drug-resistant TB dataset will be released to develop a machine learning model for drug-resistant TB detection and stratification. Besides, Score-CAM-based visualization technique was used to make the model interpretable to see where the best performing model learns from in classifying the image. The proposed approach shows an accuracy of 93.32% for the classification of TB, non-TB, and healthy patients on the largest dataset while around 87.48% and 79.59% accuracy for binary classification (drug-resistant vs drug-sensitive TB), and three-class classification (multi-drug resistant (MDR), extreme drug-resistant (XDR), and sensitive TB), respectively, which is the best reported result compared to the literature. The proposed solution can make fast and reliable detection of TB and drug-resistant TB from chest X-rays, which can help in reducing disease complications and spread.
Real-world prognostic significance of attaining minimal residual disease negativity in newly diagnosed multiple myeloma
Authors: Wang Jing , Li Jing , Zhang Run , Li Jianyong , Chen Lijuan , Jin Yuanyuan 
Published: February 2024

AbstractThe aim of the study was to evaluate the prognostic impact of minimal residual disease (MRD) in the real-world setting and the interaction between MRD and molecular risk, clinical response and autologous stem-cell transplant (ASCT). A retrospective analysis of 275 newly diagnosed multiple myeloma (NDMM) patients who achieved very good partial remission (VGPR) or better before maintenance were involved. We examined MRD status by multiparameter flow cytometry (MFC). At a median follow-up of 37 months (4–88 months), In patients who achieved ≥ VGPR, those with MRD negativity had significantly longer PFS (51 vs. 26 months; P < 0.001) and OS (Not reached: NR vs. 62 months, P < 0.001) than those with MRD positivity. MRD positivity was the independent prognostic factor for PFS with hazard ratios of 2.650 (95% CI 1.755–4.033, P < 0.001) and OS with hazard ratios of 2.122 (95% CI 1.155–3.899, P = 0.015). Achieving MRD negativity was able to ameliorate a poor prognosis associated with genetic high risk. MRD negativity was associated with better PFS regardless of ASCT treatment. MRD status was more predictable for clinical outcome than conventional clinical responses. Moreover, Sustained MRD negativity ≥ 12 or ≥ 24 months improved both PFS and OS. Patients with NDMM who achieved MRD-negative status or sustained MRD negativity had deep remission and improved clinical outcomes regardless of high-risk cytogenetics, ASCT and clinical responses in a real-world setting.
Evaluation of vibration properties of an 18-story mass timber–concrete hybrid building by on-site vibration tests
Authors: Miyazu Yuji , Loss Cristiano 
Published: February 2024

AbstractTimber–concrete hybrid structural systems are a practical option to provide tall mass timber buildings with a lateral load-resisting system. This paper discusses the dynamic behavior of an 18-story timber–concrete hybrid building based on the vibration properties evaluated by on-site vibration tests. First, microtremor measurements and human-powered excitation tests were carried out and the obtained vibration data were analyzed using a stochastic subspace identification method to derive natural frequencies, damping ratios, and mode shapes. Then, a finite-element (FE) model was developed based on detailed structural design information, and its eigenvalues and eigenvectors were compared with the test results. The vibration test results showed various mode shapes, including in-plane deformation of the floor diaphragm composed of cross-laminated timber (CLT) panels. The damping ratios in all the modes were scattered between 1 and 3%, and no frequency dependency was observed. The modal properties of the FE model agreed well with the test results by considering the additional stiffness of non-structural components. In order to simulate the in-plane deformation of the CLT floor diaphragm, detailed modeling of the connection between each CLT floor panel and the connection between CLT floor panels and concrete cores is recommended. The findings provide practitioners with an insight into dynamic properties and FE modeling methods of tall timber–concrete hybrid buildings.
A qualitative investigation into perceived barriers experienced by European female agri-food entrepreneurs
Authors: McDonagh Maria , Ryan Tansy , Moran Aisling , Ryan Lisa 
Published: February 2024

Abstract
Purpose
Agri-food systems in Europe are predominantly male dominated. Female food entrepreneurs can play a key role in the development of novel, sustainable food products. The aim of the present study was to gain an increased understanding of the various barriers which female agri-food entrepreneurs situated in rural areas perceive as hindrances to their entrepreneurial growth and development and their opinions on mentorship programmes.

Methodology
Seven separate focus groups comprising of a total of 25 female participants were carried out with agri-food entrepreneurs throughout Europe (Ireland, Belgium, Poland, Italy). Discussions were semi-structured and revolved around individuals’ perceptions of the support received from their surrounding infrastructure and their opinions on barriers and enablers for entrepreneurship development. A reflective thematic analysis was conducted following verbatim transcription of the conversations from the focus groups.

Findings
Three major themes were identified. Barriers to business development included the lack of adequate financial support and the frustrations experienced with the complexity of funding applications. Socio-cultural support was oftentimes lacking. Participants were aware of the benefits of an online presence to develop their business but lacked confidence in their digital abilities. Few female entrepreneurs were aware of mentorship programmes, and most were unsure what this practice would entail. These findings highlight a range of issues in need of addressing to improve the infrastructure surrounding female agri-food entrepreneurs throughout Europe.
Pseudo-differential operators on the circle, Bernoulli polynomials
Authors: Gay Roger , Sebbar Ahmed 
Published: February 2024

AbstractWe show how the classical polylogarithm function $$\textrm{Li}_s(z)$$

Li
s

(
z
)

and its relatives, the Hurwitz zeta function and the Lerch function are all of a spectral nature, and can explain many properties of the complex powers of the Laplacian on the circle and of the distribution $$(x+i 0)^s$$

(
x
+
i
0
)

s

. We also make a relation with a result of Keiper [Fractional Calculus and its relationship to Riemann’s zeta function, Master of Science, Ohio State University, Mathematics (1975)].