bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxosynthese mit chlorierten Äthylenen
Authors: Gut G. , El‐Makhzangi M. H. , Guyer A. 
Published: December 2004

AbstractEs wurde die Hydroformylierung von 1,1‐Dichloräthylen, 1,2‐Dichloräthylen und Vinylchlorid mit Kobalthydrogencarbonyl und Dikobaltoctacarbonyl unter milden Oxosynthesebedingungen studiert. Während mit 1,2‐Dichloräthylen keine chlorierten Aldehyde gebildet wurden, konnte mit 1,1‐Dichloräthylen und Kobalthydrogencarbonyl neben 1,1‐Dichloräthan α‐Monochlorpropionaldehyd und α‐Monochloracrolein identifiziert werden. Vinylchlorid ergab in ca. 90% Ausbeute α‐Monochlorpropionaldehyd neben geringen Mengen Acrolein, Propionaldehyd und Äthylchlorid. Die Ausbeute an α‐Monochlorpropionaldehyd wird durch niedrige Temperaturen, kurze Reaktionszeiten und hohes Verhältnis von Wasserstoff zu Kohlenmonoxid begünstigt.
Synthese einiger 2‐Dialkylaminoalkoxy‐6‐alkylamino‐ und 2‐Dialkylaminoalkylamino‐6‐alkoxy‐pyridine
Authors: Büchi J. , Allisson S. , Vetsch W. 
Published: December 2004

AbstractAus 2,6‐Dichlorpyridin wurden über die 2‐Dialkylaminoalkylamino‐6‐chlorpyridine einige 2‐Dialkylaminoalkylamino‐6‐n‐butoxy‐pyridine und 2‐Dialkylaminoalkoxy‐6‐n‐butylamino‐pyridine hergestellt. Einige der hergestellten Verbindungen besitzen eine geringe motilitätsdämpfende, histaminantagonistische und lokalanästhetische Wirkung (siehe Tabelle 2), die aber eine weitere pharmakologische und klinische Prüfung nicht rechtfertigt.
Darstellung substituierter 2, 6‐Dioxo‐2, 3, 4, 6‐tetrahydro‐pyrido[2, 1‐a] isoindole. 1. Mitteilung
Authors: Viscontini M. , Kaiser W. , Leidner H. A. 
Published: December 2004

AbstractN‐Phtaloyl‐β‐alanylchlorid und Essigester werden mittels Magnesiumäthylat zu N‐Phtaloyl‐β‐alanyl‐acetessigester (IVa) kondensiert, der sich leicht in wasserhaltigem Pyridin zu 1‐Acetyl‐2,6‐dioxo‐2,3,6‐tetrahydro‐pyrido[2,1‐a]isoindol (IIa) cyclisieren lässt. Mit dem gleichen Verfahren wird 1‐Acetyl‐3‐phenyl‐2,6‐dioxo‐2,3,4,6‐tetrahydro‐pyrido[2,1‐a]isoindol (IIb) hergestellt. Die Richtigkeit der Struktur IIa wird bewiesen.
Die BECKMANN‐Umlagerung und Fragmentierung von optisch aktiven α‐trisubstituierten Ketoximtosylaten
Authors: Fischer H. P. 
Published: December 2004

AbstractThe solvolyses of optically pure (−)‐anti‐2‐methyl‐2‐phenyl‐butyrophenonoxime tosylate and anti‐3‐methyl‐3‐phenyl‐2‐pentanonoxime tosylate in methanol and chloroform have been studied. In methanol rearrangement to amide with retained configuration of the migrating group is accompanied by fragmentation to predominantly inverted 2‐phenyl‐2‐methoxy‐butane. N‐Alkyl‐nitrilium salts are common intermediates for rearrangement and fragmentation. Since the heterolysis of N‐alkyl nitrilium ions is energetically related to SN1 reactions of alkyl halogenides or alkyl esters, the stereochemical course has been interpreted in terms of DOERING's mechanistic hypothesis for endothermic SN1 reactions.
Zur Kenntnis der Hexaalkylbenzole. 8. Mitteilung. Seitenkettenreaktionen des Hexa‐(n‐propyl)‐benzols
Authors: Hopff H. , Gati A. 
Published: December 2004

AbstractLight‐activated bromination of hexa‐n‐propyl‐benzene gives hexa‐(α‐bromo‐n‐propyl)‐benzene, which can be dehalogenated to a new hydrocarbon, hexapropylidenecyclohexane.
Über die sogenannte anomale CLAISEN‐Umlagerung. 2. Mitteilung
Authors: Habich A. , Barner R. , von Philipsborn W. , Schmid H. 
Published: December 2004

AbstractThe mechanism of the abnormal CLAISEN rearrangement, that is the isomerisation of o‐allylphenols, has been investigated using deuterium as tracer. The incorporation and distribution of the label was followed by proton and deuterium NMR. analysis.
Alstophyllin, ein neues Indolalkaloid aus Alstonia macrophylla WALL
Authors: Kishi T. , Hesse M. , Gemenden C. W. , Taylor W. I. , Schmid H. 
Published: December 2004

AbstractAus Alstonia macrophylla WALL. wurde ein neues Alkaloid, Alstophyllin, isoliert. Auf Grund seiner Hydrolyse in ein ketonisches Spaltstück 6 und Ameisensäure sowie spektroskopischer – insbesondere massenspektrometrischer – Daten wurde ihm die Struktur 1 zuerteilt.
Polare Imprägnierung von Glaskapillaren für die Gas‐Chromatographie
Authors: Grob Kurt 
Published: December 2004

AbstractAccording to the experience of various authors, glass capillaries used as columns for gas chromatography can be coated only with non‐polar liquids such as squalane and apiezon. This paper shows that polar liquids form a coherent film on a glass surface which has first been covered by an approx. 0.001 μ layer of carbon black. Several methods for producing these layers are described. Such pretreated glass capillaries show equal or better separation efficiencies than steel capillaries and work at lower temperatures, due to their lower adsorption activity.
Die Strukturen der mittleren Ringverbindungen. IX. 1, 8‐Diazacyclotetradecan‐dihydrobromid
Authors: Dunitz J. D. , Meyer E. F. 
Published: December 2004

AbstractCrystals of 1,8‐diazacyclotetradecane dihydrobromide are orthorhombic, a = 13.58, b = 14.81, c = 8.01 Å, Z = 4, space group Pccn (D). The conformation of the 14‐membered ring has been established from three‐dimensional X‐ray analysis. It corresponds closely to an idealized conformation based on the diamond lattice.
FRIEDEL‐CRAFTS‐Reaktionen mit aromatischen äthern. 1. Mitteilung Die Herstellung von Alkoxy‐indanonen‐(1)
Authors: Marquardt F.‐H. 
Published: December 2004

AbstractThe products resulting from condensation of veratrole and α,β‐unsaturated acids in polyphosphoric acid are the corresponding 1‐indanones. With pyrogallol trimethyl ether and with resorcinol dimethyl ether the nature of the products of these condensations varies according to the α,β‐unsaturated acid employed. Usually it will be a phenyl vinyl ketone, which agrees with the results given in the literature for the reaction with anisole. The ability of the various aromatic ethers to form indanones by this condensation is discussed on the basis of the π‐electron density in the different positions of the aromatic ethers.
Die Cardenolide von Parquetina nigrescens (AFZEL.) BULLOCK. Glykoside und Aglykone, 270. Mitteilung [1]
Authors: Berthold R. , Wehrli W. , Reichstein T. 
Published: December 2004

AbstractSix crystalline (A, C, E, H, J and K) and six amorphous (α, γ, A1, D, D′, and G) but paperchromatographically homogenous cardenolides were isolated from the wood of Parquetina nigrescens (AFZEL.) BULLOCK (= Periploca nigrescens AFZEL.) after fermentation with glucosidases. The presence of twelve more cardenolides was observed in paperchromatograms. Three of the mentioned compounds could be identified with known substances: A = strophanthidin (already isolated by SCHENKER et al. [3] from similar material), H = strophadogenin = 16β‐hydroxystrophanthidin and J = convallatoxin. A1, C, D, E, and K are new compounds whose structures will be reported in the following publication. The structures of α, γ, D′ and G are as yet unknown.
Die Konstitution von Verrucarin J. Verrucarine und Roridine, 9. Mitteilung [1]
Authors: Fetz E. , Böhner B. , Tamm Ch. 
Published: December 2004

AbstractThe antibiotic verrucarin J (C27H32O9) yields on base catalysed hydrolysis verrucarol (3), cis,trans‐muconic acid (5) and 5‐hydroxy‐3‐methyl‐2‐pentenoic acid lactone (6). 6 is a secondary reaction product of the genuine cis‐5‐hydroxy‐3‐methyl‐2‐pentenoic acid (10). In the antibiotic the three fragments 3, 5 and 10 are united to form a macrocyclic triester. Their sequence is deduced on the basis of the partial hydrolysis of verrucarin J leading to the dihydroxyester 11. Structure 1 is assigned to verrucarin J.
Komplexone XXXVIII. Reaktionsenthalpie und ‐entropie bei der Bildung der 1:1‐und 1:2‐Metallkomplexe von Methyliminodiessigsäure
Authors: Anderegg G. 
Published: December 2004

AbstractThe enthalpy changes involved in the metal complex formation with methyliminodiacetate‐ion have been determined, using a direct calorimetric method. The thermodynamic data obtained are used to calculate the chelate effect with the EDTA‐homologous (−OOCCH2)2 = N(CH2)nN = (CH2COO−)2 as ligand.
Synthese von in 10‐Stellung basisch substituierten 9,9‐Dialkylacridanen
Authors: Molnar I. , Wagner‐Jauregg Th. 
Published: December 2004

AbstractEs wird über die Synthese von in 10‐Stellung basisch substituierten 9,9‐Dialkyl‐acridanen nach drei Methoden berichtet. Unter den hergestellten Verbindungen zeigen das N‐Methyl‐3′‐aminopropyl‐9,9‐dimethyl‐acridan (SD 735) und das entsprechende N‐Dimethyl‐Analoge (SD 25) im Tierversuch Antireserpin‐Wirkung und bei der klinischen Prüfung thymoleptische (antidepressive) Eigenschaften.
Synthèse de l'Ala1‐Ala6‐Arg8‐vasopressine et de l'Ala1‐Ala6‐Lys8‐vasopressine, ainsi que de la (déamino‐Ala)1‐Ala6‐Arg8‐vasopressine et de la (désamino‐Ala)1‐Ala6‐Lys8‐vasopressine
Authors: Huguenin R. L. , Guttmann St. 
Published: December 2004

AbstractAla1‐Ala6‐Arg8‐vasopressin, Ala1‐Ala6‐Lys8‐vasopressin, (Deamino‐Ala)1‐Ala6‐Arg8‐vasopressin and (Deamino‐Ala)1‐Ala6‐Lys8‐vasopressin were prepared by condensation of a tripeptide azide or, respectively, a propionyl‐dipeptide azide with a hexapeptide amide, both fragments having been synthesized by methods excluding racemization. These peptides represent analogues of arginine‐vasopressin, lysinevasopressin and of their deamino derivatives, in which the ring is open and the sulphur atoms are replaced by hydrogen atoms. The new peptides were found to be devoid of any biological activity and did not inhibit the corresponding natural hormones. The significance of this observation is discussed.
Synthèse de la Gly8‐oxytocine, de l'Ala8‐oxytocine et de la But8‐oxytocine
Authors: Jaquenoud P.‐A. 
Published: December 2004

AbstractGly8‐oxytocin and Ala8‐oxytocin have been synthesized according to the 3+6 scheme, and But8‐oxytocin to the full recurring scheme, active esters having been used almost throughout for the formation of peptide bonds. The comparison of their biological activities with those of oxytocin, Val8‐oxytocin and Ile8‐oxytocin, shows that omission of the aliphatic side chain of the amino‐acid in position 8 strongly depresses the activities. Nevertheless an ethyl group (But8‐oxytocin) and even a methyl group (Ala8‐oxytocin) are sufficient to confer to the, molecule a high degree of activity.
Synthesen in der Isochinolinreihe Zur partiellen Ätherspaltung 6,7‐dimethoxy‐substituierter 3,4‐Dihydro‐isochinoline und Isochinoline
Authors: Bruderer H. , Brossi A. 
Published: December 2004

AbstractThe selective ether cleavage observed with 6,7,8‐trimethoxy‐substituted 3,+‐dihydroisoquinolines and isoquinolines under the influence of 20% hydrochloric acid takes place in the analogous 6,7‐dimethoxy series with concentrated hydrobromic acid at 100°. This constitutes an easy route to 6‐methoxy‐7‐hydroxy‐isoquinoline derivatives.
Reversible Umlagerung eines cis‐2‐Vinyl‐cyclopropylformaldehydes zu einem Dihydrooxepin. Vorläufige Mitteilung
Authors: Rey Max , Dreiding André S. 
Published: December 2004

AbstractEvidence is given for a fast reversible 2‐vinylcyclopropylformaldehyde‐dihydro‐oxepine rearrangement. Bicyclo[3.1.0]hex‐2‐ene‐6‐endo‐formaldehyde and 2‐oxa‐bicylo[3.2.1]octa‐3,6‐diene coexist in a 7:3 equilibrium, which is pulled in the direction of the enol ether by a cycloaddition with tetracyanoethylene, and in the direction of the aldehyde by interaction with LiAlH4, Ag2O or NaHSO3. Decomposition of the pure hydrogensulfite adduct of the aldehyde refurnishes the 7:3 mixture.
Réactions du diazométhane. I. Transformation de la fonction N‐phénylthio‐carbonyle (C6H5SCO‐NH‐R) avec production d'isocyanate (OCNR) par élimination bimoléculaire
Authors: Baudet P. , Calin M. , Cherbuliez E. 
Published: December 2004

AbstractDiazomethane transforms N‐(phenylthio‐carbonyl)‐amino acid esters or amides into the corresponding N‐carbonyl derivatives, similarly it converts N‐(phenylthio‐carbonyl)‐butyl‐1‐amine into butyl‐isocyanate. Solvents with a high dielectric constant (e. g. nitromethane, ethanol) favour this transformation. The analogous but N‐substituted N‐(phenyloxy‐carbonyl)‐amino acid esters are not modified by diazomethane. This new reaction appears to proceed by a bimolecular elimination (E2), where the transition state leads very rapidly to the formation of an isocyanate on the one hand and thio‐anisole on the other.
3‐Hydroxy‐1,2,4‐benzotriazin‐1‐oxid‐7‐carbonsäure und verwandte Verbindungen
Authors: Brenneisen K. , Thumm O. , Benz J. 
Published: December 2004

AbstractThe chloride of 3‐chloro‐1,2,4‐benzotriazine‐1‐oxide‐7‐carboxylic acid has been prepared, and from this a number of derivatives of 3‐hydroxy‐1,2,4‐benzotriazine‐1‐oxide‐7‐carboxylic acid were synthesized by stepwise substitution of the two halogen atoms. This acid chloride has further been used for linking dye components containing amino groups, and for the synthesis of reactive dyes whose suitability for dyeing cellulose and wool has been examined.
Die Zusammensetzung der Neutrallipide aus normalen Hirnen alter Menschen
Authors: Lesch Peter , Meier Sylvia , Bernhard Karl 
Published: December 2004

AbstractThe chemical composition of lipids from six human brains (60–73 years) is reported. The total lipids out of cortex, white matter, diencephalon and cerebellum, pons, and medulla oblongata have been isolated and the neutral lipids have been separated in cerebrosides, sphingomyelines, and lecithins. The highest amount of pure lipids is found in the white matter, the lowest in the cortex. The relation of neutral lipids to acid lipids as well as the amount of cholesterol are about equal for all regions. The white matter shows more cerebrosides and sphingomyelines than the cortex, the opposite being the case for lecithins. The differences are strongly significant. The fatty acids out of the different pure lipid fractions have been analysed as esters by gas chromatography. Stearic and lignoceric acid, and cerebronic and hydroxy nervonic acid respectively are main components of cerebrosides, with only little differences for the different brain regions. The fatty acids of sphingomyelines consist mainly of stearic and nervonic acid; in the white matter these two acids are present about in the same quantity, whereas stearic acid dominates in the cortex and the other sections. Lecithins contain above all palmitic and oleic acid. The amount of the latter in the white matter is higher than that of palmitic acid.
Organische Phosphorverbindungen XXII. Darstellung und Eigenschaften von diprimären α,ω‐Bis‐phosphino‐alkanen
Authors: Maier Ludwig 
Published: December 2004

AbstractThe preparation and properties of diprimary α,ω‐bis‐phosphino‐alkanes of the general structure H2P(CH2)n PH2 (n = 1, 2, 3, 4) are described. Their reactions with N‐hydroxymethyl‐dialkylamines and with olefins, which yield ditertiary α,ω‐bisphosphino‐alkanes, (R2NCH2)2P(CH2)nP(CH2NR2)2 and R2P(CH2)nPR2, respectively, are also reported. The physical properties of two new α,ω‐bis‐dialkylphosphinyl‐alkanes have been determined.
Metallionen und H2O2. VI. Über Struktur und Aktivität der den H2O2‐Zerfall katalysierenden Ni2+‐Komplexe
Authors: Zell R. , Sigel H. 
Published: December 2004

AbstractThe catalytic properties in H2O2 decomposition of Ni2+‐chelates of the following ligands have been investigated: ethylenediamine, diethylenetriamine, triethylenetetramine, 2,2′‐bipyridine, pyrophosphate and ethylenediamine‐N, N, N′, N′‐tetra‐acetic acid, and of the following peptides and peptide‐like ligands: glycylglycine, N,N′‐diglycyl‐ethylenediamine, N, N′‐diglycyl‐1, 5‐diaminopentane and polymyxin B.
De la chimie des ptérines. 15e communication. Hydroxylation non‐enzymatique de la phénylalanine en tyrosine à l'aide de ptérines tétrahydrogénées
Authors: Bobst A. , Viscontini M. 
Published: December 2004

AbstractThe non‐enzymatic hydroxylation of phenylalanine to tyrosine has been effected by atmospheric oxygen in aqueous solution in the presence of 5,6,7,8‐tetrahydropterines, FeII or FeIII, and EDTA, in a phosphate buffer at pH 6,9. A possible reaction mechanism is discussed.
Synthese von in 2‐Stellung substituierten 2‐Amino‐ und 3‐Amino‐1‐indanonen
Authors: Allisson S. , Büchi J. , Michaelis W. 
Published: December 2004

AbstractAn examination has been made of the reaction of secondary amines with 2‐bromo‐1‐indanones II substituted at position C‐2, and with 2‐substituted indenones III. 2‐Bromo‐2‐methyl‐1‐indanone (IIa) and dimethylamine yielded a mixture of the corresponding 2‐ and 3‐amino‐methylindanones IVa and Va. 2‐Bromo‐2‐methyl‐6‐chloro‐1‐indanone (II b) and morpholine gave a mixture of the 2‐ and 3‐aminocompounds IVe and Ve.
Macralstonin
Authors: Kishi T. , Hesse M. , Vetter W. , Gemenden C. W. , Taylor W. I. , Schmid H. 
Published: December 2004

AbstractDas aus Alstonia macrophylla Wall. (A pocynaceae) isolierte «dimere» Indolalkaloid Macralstonin lässt sich durch verdünnte Salzsäure in die Villalstonin‐Spaltbase Macrolin (8) und das ebenfalls aus Alstonia macrophylla isolierte Alkaloid Alstophyllin (2) spalten. Daraus und auf Grund spektroskopischer Untersuchungen (UV.‐, IR.‐, NMR.‐, Massenspektren) wird für Macralstonin die Struktur 1 abgeleitet.
Die Struktur des Alkaloides Pleiomutin: massenspektrometrische Analyse und Partialsynthese
Authors: Hesse M. , Bodmer F. , Schmid H. 
Published: December 2004

AbstractFür Pleiomutin, ein «dimeres» Indolalkaloid aus Pleiocarpa mutica BENTH., wird auf Grund des Massenspektrums, seiner Hydrolyse zu Pleiocarpinin (3) und seiner Partialsynthese aus 3 und Eburnamin (7) die Konstitution 1 abgeleitet.
Über Dibenz[b,f]‐azocin‐Derivate
Authors: Schindler O. , Blaser R. , Hunziker F. 
Published: December 2004

AbstractAus o‐Aminodibenzyl (I) und o‐Amino‐cis‐stilben (IV) wurden mit Phosgen die Isocyanate II bzw. VIII hergestellt. Diese wurden als Harnstoffe V bzw. VII charakterisiert. Mit AlCl3 in Dichlorbenzol behandelt, ging II in das Azocin III über, während aus VIII das Indolon IX entstand.
Organische Phosphorverbindungen XXIII. Sekundäre Phosphinselenide, eine neue Klasse von organischen Phosphorverbindungen
Authors: Maier Ludwig 
Published: December 2004

AbstractThe preparation and properties of secondary phosphine selenides, R2P(Se)H(R = i‐C4H9, C6H5), a new class of organophosphorus compounds, are described.
Zur thermodynamisch‐phänomenologischen Beschreibung der Färbevorgänge I. Diskontinuierliches Modellsystem
Authors: Milićević B. , McGregor R. 
Published: December 2004

AbstractThe essential characteristics of a simple, discontinuous model system for mass transfer between two phases are discussed. It is shown that for dyeing processes that conform to this model it is possible, with the aid of the methods of non‐equilibrium thermodynamics, to give an unambiguous definition of the concepts «rate of dyeing» and «affinity of dyeing», at any stage of dyeing. It is clear from the derived phenomenological equations that dyeing systems rarely reach a true equilibrium state (i.e. a stationary state of zero order), but that in general an osmotic or a DONNAN equilibrium is attained.
Untersuchungen über den Mechanismus der beiden Azosynthesen von SUCKFÜLL & DITTMER. 18. Mitteilung zur Kenntnis der Azokupplungsreaktion
Authors: Christen M. , Funderburk L. , Halevi E. A. , Lewis G. E. , Zollinger Hch. 
Published: December 2004

Abstract15N‐Tracer techniques have been employed to investigate the reactions of aryldiazonium ions with aryldiazosulphonates and with aryldiazotates (SUCKFÜLL‐DITTMER azo syntheses), in which unsymmetrical azo compounds and o‐hydroxyazo compounds respectively are formed as the main products, with concomitant elimination of molecular nitrogen.
FRIEDEL‐CRAFTS‐Reaktionen der C7‐, C8‐ und C12‐Cycloalkane mit Kohlenmonoxid
Authors: Hopff H. , von Rütte R. 
Published: December 2004

AbstractThe reaction of cycloheptane, cyclooctane, and cyclododecane with carbon monoxide under pressure in the presence of anhydrous aluminium chloride has been investigated. Cycloheptane leads to acetylcyclohexane and trans‐2‐methyl‐cyclohexane carboxylic acid as main products. Cyclooctane yields 3‐ and trans‐4‐acetyl‐methylcyclohexane and various dimethylcyclohexane carboxylic acids. From cyclododecane a mixture of numerous ketones has been obtained besides a mixture of acids.
Sur les esters activés III. Nouvelle synthèse des dioxo‐2,5‐pipérazines et étude de leurs propriétés chimiques
Authors: Buyle R. 
Published: December 2004

AbstractBy reacting an α‐amino acid N‐carboxyanhydride with an amidoxime the dioxopiperazine derived from the parent amino acid is formed in quantitative yield. In this way the dioxopiperazine of glutamic acid, which is not otherwise accessible, has been prepared.
Massenspektren einiger SCHIFF'schen Basen des Pyridin‐2‐aldehyds
Authors: Schumacher Ernst , Taubenest Richard 
Published: December 2004

AbstractPhotographically recorded high‐resolution mass spectra of some SCHIFF bases of pyridine‐2‐aldehyde are presented. Fragmentation patterns of the primary ions formed under electron impact are discussed in connection with a proposed four‐membered cyclic transition state.
Über die Reaktion substituierter Thioxanthenoxide mit Säuren
Authors: Schindler O. , Michaelis W. , Gauch R. 
Published: December 2004

Abstract9‐[(N‐Methyl‐3′‐piperidyl)‐methyl]‐thioxanthene‐10‐oxide (I) on treatment with boiling concentrated hydrochloric acid gives mainly 9‐[(N‐methyl‐3′‐piperidyl)‐methylene]‐thioxanthene (IV) together with small amounts of 9‐[(N‐methyl‐3′‐piperidyl)‐chloro‐methylene]‐thioxanthene(II), 9‐hydroxy‐9‐[(N‐methyl‐3′‐piperidyl)‐methyl]‐thioxanthene (III) and 9‐[(N‐methyl‐3′‐piperidyl)‐methyl]‐thioxanthene (V). Treatment of I with acetic anhydride yields only IV.
Sensibilité au choc des explosifs chimiques solides. A propos d'une note récente d'A. J. A. van der Wyk
Authors: Cruchaud M. 
Published: December 2004

AbstractLa sensibilité au choc d'un explosif chimique solide n'est pas, comme l'a pensé A. J. A. VAN DER WYK, déterminée par sa chaleur spécifique.
Die Glykoside der Samen von Stapelia gigantea N. E. Br. Glykoside und Aglykone, 275. Mitteilung
Authors: Eppenberger U. , Kaufmann H. , Stöcklin W. , Reichstein T. 
Published: December 2004

AbstractThe seeds of Stapelia gigantea are very rich in ester glycosides (ca. 5,9%). Mild acid hydrolysis gave a mixture of sugars which, after paper chromatography and electrophoresis, was found to be probably composed of cymarose, oleandrose, digitoxose, arabino‐2,6‐dideoxyhexose (= canarose) and pachybiose. The mixture of the raw genins gave after alkaline hydrolysis a mixture of about nine deacyl genins (C, D, E, F1, F2, F3, G, H, J); the acids split off during hydrolysis were not identified. The nine deacyl genins are probably closely related pregnane derivatives. The main component (E), C21H30O4, was obtained in crystalline state, and was named stapelogenin. Its probable structure is reported in the following publication.
Zur Synthese des Ecdysons. II. Mitteilung über Insektenhormone Synthesen von 2β, 3β‐Dihydroxy‐6‐keto‐A|B‐cis‐Steroiden
Authors: Wiechert R. , Kerb U. , Hocks P. , Furlenmeier A. , Fürst A. , Langemann A. , Waldvogel G. 
Published: December 2004

AbstractExperiments towards a synthesis of ecdysone (1) ([22R]‐2β, 3β, 14, 22, 25‐pentahydroxy‐5β, 14α‐cholest‐7‐en‐6‐one) have led to 2β, 3β‐dihydroxy‐6‐keto‐5α‐steroids. These could be epimerized to the corresponding 5β‐series. The proposed configurational assignments are supported by physical data and chemical correlation.
Zur Synthese des Ecdysons. III. Mitteilung über Insektenhormone. Synthesen von 2β, 3β, 14α‐Trihydroxy‐6‐keto‐Δ7‐A|B‐cis‐Steroiden
Authors: Furlenmeier A. , Fürst A. , Langemann A. , Waldvogel G. , Kerb U. , Hocks P. , Wiechert R. 
Published: December 2004

AbstractThe synthesis of the tetracyclic skeleton of ecdysone with correct stereochemistry and substitution is described. 22,25‐Didehydroxy‐ecdysone and methyl (20S)‐2β,3β‐dihydroxy‐6‐oxo‐5β‐pregn‐7‐ene‐20‐carboxylate have been prepared. The latter is a key intermediate in the synthesis of ecdysone.