bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Assembly of Cryo(Bio)Printed Modular Units for Shelf‐Ready Scalable Tissue Fabrication
Authors: Luo Zeyu , Lian Liming , Stocco Thiago , Guo Jie , Mei Xuan , Cai Ling , Andrabi Syed Muntazir , Su Yajuan , Tang Guosheng , Ravanbakhsh Hossein , Li Wanlu , Wang Mian , Kuang Xiao , Garciamendez‐Mijares Carlos Ezio , Wang Di , Wang Zongliang , Liao Junlong , Xie Maobin , Xie Jingwei , Kang Heemin , Lobo Anderson Oliveira , Zhou Zongke , Zhang Yu Shrike 
Published: November 2023

AbstractThe human body relies on modular assembly for realizing its functions. Here the development of a bioinspired cryo(bio)printing‐based method is reported to fabricate shelf‐ready, storable modular scaffolds toward scalable tissue assembly. The mechanism lies in that the cryo(bio)printed modular scaffolds are first assembled into the final hierarchy in their frozen state, which can be subsequently bonded together into an integral piece by contacting each other at the interface during the melting and photocrosslinking processes. This method not only addresses the height limitation associated with the recently developed cryo(bio)printing technology by enabling scalable tissue fabrication through modular assembly, but also allows generating tissue constructs of same or dissimilar materials to fit defects of different scales and shapes, thus providing more precision treatment. Cellular evaluations on the cryobioprinted modular hydrogels validate cell viability, spreading, and differentiation following assembly. The chick ex ovo and rat subcutaneous implantation assays further confirm the potential of direct in vivo assembly using shelf‐ready cryobioprinted modular tissue constructs.
Bioactives and Biomaterial Construction for Modulating Osteoclast Activities
Authors: He Yuwei , Jiang Hong , Dong Shiwu 
Published: November 2023

AbstractBone tissue constitutes 15–20% of human body weight and plays a crucial role in supporting the body, coordinating movement, regulating mineral homeostasis, and hematopoiesis. The maintenance of bone homeostasis relies on a delicate balance between osteoblasts and osteoclasts. Osteoclasts, as the exclusive “bone resorbers” in the human skeletal system, are of paramount significance yet often receive inadequate attention. When osteoclast activity becomes excessive, it frequently leads to various bone metabolic disorders, subsequently resulting in secondary bone injuries, such as fractures. This not only reduces life quality of patients, but also imposes a significant economic burden on society. In response to the pressing need for biomaterials in the treatment of osteoclast dysregulation, there is a surge of research and investigations aimed at osteoclast regulation. Promising progress is achieved in this domain. This review seeks to provide a comprehensive understanding of how to modulate osteoclast activities. It summarizes bioactive substances that influence osteoclasts and elucidates strategies for constructing related biomaterial systems. It offers practical insights and ideas for the development and application of biomaterials and tissue engineering, with the hope of guiding the clinical treatment of osteoclast‐related bone diseases using biomaterials in the future.
Palygorskite‐Derived Ternary Fluoride with 2D Ion Transport Channels for Ampere Hour‐Scale Li‐S Pouch Cell with High Energy Density
Authors: Zhang Shilin , Sarwar Muhammad Tariq , Wang Jie , Wang Gang , Jiang Zhiyi , Tang Aidong , Yang Huaming 
Published: November 2023

AbstractAlthough various excellent electrocatalysts/adsorbents have made notable progress as sulfur cathode hosts on the lithium‐sulfur (Li‐S) coin‐cell level, high energy density (WG) of the practical Li‐S pouch cells is still limited by inefficient Li‐ion transport in the thick sulfur cathode under low electrolyte/sulfur (E/S) and negative/positive (N/P) ratios, which aggravates the shuttle effect and sluggish redox kinetics. Here a new ternary fluoride MgAlF5·2H2O with ultrafast ion conduction–strong polysulfides capture integration is developed. MgAlF5·2H2O has an inverse Weberite‐type crystal framework, in which the corner‐sharing [AlF6]–[MgF4 (H2O)2] octahedra units extend to form two‐dimensional Li‐ion transport channels along the [100] and [010] directions, respectively. Applied as the cathode sulfur host, the MgAlF5·2H2O lithiated by LiTFSI (lithium salt in Li‐S electrolyte) acts as a fast ionic conductor to ensure efficient Li‐ion transport to accelerate the redox kinetics under high S loadings and low E/S and N/P. Meanwhile, the strong polar MgAlF5·2H2O captures polysulfides by chemisorption to suppress the shuttle effect. Therefore, a 1.97 A h‐level Li‐S pouch cell achieves a high WG of 386 Wh kg−1. This work develops a new‐type ionic conductor, and provides unique insights and new hosts for designing practical Li‐S pouch cells.
A Bio‐Inspired Free‐Standing Film with Versatility: From Heterogeneous CTCs Programed Isolating to Breast Cancer Molecular Typing
Authors: Bai Mengqi , Qin Rong , Cheng Kai , Wang Zengkai , Zhang Liwei , Tian Xiaohua , Zhang Feiyi , Yang Yuhe , Hou Shuai , Xu Jian , Liu Lei 
Published: November 2023

AbstractDeveloping a robust strategy for profiling heterogeneous circular tumor cells specifically, distinguishing the phenotypes of which in blood sample of cancer patient precisely, and releasing them sequentially, is significant for cancer management by liquid biopsy. Herein, a bio‐inspired free‐standing and flexible film composed of TiO2 nanotube and silk fibroin, fabricated with multiply dynamic bioactive surface (TSF/MDBS) by a simple and eco‐friendly way including using polydopamine chemistry and dual dynamic covalent chemistry, is reported. The as‐prepared TSF/MDBS binds specific peptides toward cells with epithelial biomarker and human epithelial growth factor receptor 2 (HER2) biomarker, and antifouling agents bovine serum albumin for obviating platelets and proteins adhering of blood, can capture heterogeneous CTCs with enhanced capability due to the cytocompatible soft film and exquisite surface design, and further release the captured cells as program, by specifically breaking down the covalent bonds in sequence via the action of adding biocompatible molecules fructose and glutathione. By applying the TSF/MDBS, it can be tailored into desired pieces for identifying CTCs with different phenotypes (HER2‐high and HER2‐low) from the unprocessed blood samples of breast cancer patients, and finally profiling these heterogeneous CTCs, to discriminate HER2 positive or negative of breast cancer patients in clinical applications.
High‐Performance N‐MoSe2/P‐GeSn/N‐Ge van der Waals Heterojunction Phototransistor for Short‐Wave Infrared Photodetection
Authors: Cai Xinwei , Li Shuo , Qian Jinhui , Ding Haokun , Wu Songsong , Wang Rui , Wu Qiang , Shentu Xiaowei , Lin Guangyang , Li Cheng 
Published: November 2023

AbstractIn this work, a high‐performance two‐terminal n‐MoSe2/p‐GeSn/n‐Ge van der Waals (vdW) heterojunction phototransistor (HPT) is proposed and demonstrated for short‐wave infrared (SWIR) detection. With a high Sn content of 17.1% in the GeSn base region, the cutoff wavelength is extended to beyond 2400 nm. The substantial electron/hole injection ratio resulting from the large bandgap offset between the MoSe2 emitter and the GeSn base enables the harvesting of high photocurrent gain. A record high responsivity of 12.75 A W−1 and an excellent specific detectivity of 1.74 × 1010 Jones at 2250 nm are achieved under a collector‐emitter bias of 1.0 V at room temperature. A response time of 462 µs at 1550 nm outbalancing that of most vdW junction‐based devices is obtained for the non‐optimized devices. Those results show that the mixed‐dimensional GeSn HPT is one of the promising candidates for detection of infrared band above 2 µm.
Single Photon Emitters in Hexagonal Boron Nitride Fabricated by Focused Helium Ion Beam
Authors: Liu Guan‐Lin , Wu Xin‐Yu , Jing Peng‐Tao , Cheng Zhen , Zhan Da , Bao Yang , Yan Jia‐Xu , Xu Hai , Zhang Li‐Gong , Li Bing‐Hui , Liu Ke‐Wei , Liu Lei , Shen De‐Zhen 
Published: November 2023

AbstractThe 2D layered hexagonal boron nitride (hBN) material is a promising platform for making single photon emitters (SPEs). Integrate SPEs with photonic cavities or waveguides, requires the deterministic positioning of these emitters as accurately as possible. Among all of the alternative techniques, He+ focused ion beam (FIB) theoretically has sub‐nanometer precision, but its practical positioning accuracy in processing SPEs is limited by the inevitable detrimental byproduct defects. So far, it remains challenging to achieve an accuracy below 100 nm for the positioning of SPEs in hBN. Here, we present a two‐step method for creating SPEs at the predetermined positions in hBN that combines the He+ FIB irradiation and thermal annealing under an oxygen atmosphere. With this method, we have realized the positioning accuracy of less than 50 nm, which, to the best of our knowledge, stands as the highest among the currently available hBN SPEs preparation methods. Moreover, the SPE conversion yield was over 35% and the emission brightness of individual SPE achieved up to 3 × 105 counts/s at room temperature. These SPEs fabricated precisely with nanoscale accuracy in hBN are expected to be good candidates for making large‐scale integrated SPEs in photonic circuits.
Various Mechanisms of Additives in Different Additive Methods on the Crystallinity of Perovskite by Synchrotron Radiation Technology
Authors: Wang Dan , Guo Xihong , Shen Zhibang , Wang Xue , Chai Yuru , Dong Jinquan , Wang Zhen , Wu Zhonghua , Chen Yu , Sun Baoyun 
Published: November 2023

AbstractAdditives are one of the important means to improve the performance of perovskite solar cells. To explore the effects of different addition methods on the crystallinity of perovskite, in this paper, guanidine thiocyanate (GASCN) is added in three different methods, i.e., added in SnO2 precursor solution; in PbI2 precursor solution; or FAI precursor solution, respectively. The guanidine hydroiodide (GAI) and methylamine thiocyanate (MASCN) are selected as contrast additives to evaluate the role of GA+ and SCN−. Though the efficiency and stability of the perovskite solar cells with all additives are improved, the systematic study by grazing incidence wide‐angle X‐ray scattering (GIWAXS), quasi‐in situ GIWAXS, and in situ X‐ray diffraction (XRD) proved that the mechanism by the three different addition methods behaved in many different ways, which corresponded, respectively, to the surface of the SnO2 electron transport layer, dominance orientation especially vertical growth of perovskite, or low‐dimensional perovskite structure. This provides a new view for optimizing the appropriate synthesis conditions in the future.
The Intermolecular Pauson‐Khand Reaction: Applications, Challenges, and Opportunities
Authors: Lledó Agustí , Solà Jordi 
Published: November 2023

AbstractThe rapid assembly of complex organic molecules from simple and structurally diverse building blocks is a prevalent challenge in organic synthesis. The Pauson‐Khand reaction (PKR) is a method of choice for the construction of five membered rings that has historically been popularized as a late‐stage intramolecular cyclization method. The intermolecular version of the PKR, on the other hand, constitutes a powerful approach for the rapid assembly of densely functionalized cyclopentanic cores at early stages of a synthetic sequence. Despite its potential, the intermolecular PKR is much less prevalent in the organic synthesis literature due to several historical limitations, most importantly a reduced scope with respect to the alkene component of the reaction. The last decade has witnessed important developments in the area including a) experimental and theoretical studies that provide a good mechanistic understanding of the reaction and its selectivity, b) methodological developments that have broadened the scope of potential alkene partners, and c) the development of catalytic enantioselective versions that provide useful levels of enantioselectivity. In parallel, remarkable synthetic applications of the intermolecular PKR have emerged, including (enantioselective) total syntheses of complex natural products (polycyclic terpenes, alkaloids, prostanes) as well as examples of industrial relevance. A fundamental limitation of the PKR that needs to be addressed in the future is the current lack of a ligand‐accelerated version of the reaction, which would be a promising advance towards developing more efficient and general catalytic (enantioselective) reactions.
CoOOH: Synthesis and Application in Alkaline Electrochemical Oxygen Evolution Reaction
Authors: Ren Xiaoqian , Dai Yulong , Wen Xinxin , Guo Bingrong , Shi Chenqi , Huang Xiaoxiao , Guo Ying , Li Siwei 
Published: November 2023

AbstractOxygen evolution reaction (OER) is the bottleneck for electrochemical water splitting due to its sluggish 4‐electron kinetics and high formation energy of O═O bond. Multiple kinds of Co‐based compounds such as oxides, hydroxides, sulfides, phosphides and so on are demonstrated to possess excellent OER activity. However, these materials will partially or fully convert to CoOOH after OER, and therefore CoOOH receive extensive research interests as the true active species for Co‐based OER catalyst in the past decade. Herein, the OER mechanism and synthesis of CoOOH and the strategies are reviewed for enhancing the OER performance of this kind of catalyst. The synthetic methods for CoOOH, including wet‐chemical oxidation method, electrochemical oxidation method, molten‐salt‐assisted synthesis and hydrothermal method will be reviewed and compared. Moreover, the strategies will be summarized for design active CoOOH‐based OER catalysts such as element doping and construction of hybrid catalysts in detail. Finally, an outlook is provided about the remaining challenges and future opportunities in this area.
Small Angle X‐Ray Scattering Study for Investigating the 3D Packing Structure of Pt Catalysts on Gd‐Doped CeO2 Supports for Fuel Cells
Authors: Omote Kazuhiko , Iwata Tomoyuki , Kakinuma Katsuyoshi 
Published: November 2023

AbstractA 3D structural model for fuel cell catalysis systems is constructed, which consist primarily of Pt and CeO2 nanoparticles, to fit observed small angle X‐ray scattering (SAXS) patterns by using the reverse Monte–Carlo (RMC) method. The observed SAXS patterns are well reproduced by those of the simulations. Pore size distributions using the obtained structure models are compared with the Barrett–Joyner–Halenda (BJH) analysis for the nitrogen gas adsorption data, and the lower quartiles and medians of the pore diameters are reasonably consistent. In addition, analysis of the SAXS patterns indicates that the number of nanometer‐size Pt particles is much smaller than that of the introduced amount. This suggests that most Pt particles are not uniformly distributed in the catalysis system.
Arf1 GTPase Regulates Golgi‐Dependent G2/M Transition and Spindle Organization in Oocyte Meiosis
Authors: Zhang Kun‐Huan , Zou Yuan‐Jing , Shan Meng‐Meng , Pan Zhen‐Nan , Ju Jia‐Qian , Liu Jing‐Cai , Ji Yi‐Ming , Sun Shao‐Chen 
Published: November 2023

AbstractADP‐ribosylation factor 1 (Arf1) is a small GTPase belonging to the Arf family. As a molecular switch, Arf1 is found to regulate retrograde and intra‐Golgi transport, plasma membrane signaling, and organelle function during mitosis. This study aimed to explore the noncanonical roles of Arf1 in cell cycle regulation and cytoskeleton dynamics in meiosis with a mouse oocyte model. Arf1 accumulated in microtubules during oocyte meiosis, and the depletion of Arf1 led to the failure of polar body extrusion. Unlike mitosis, it finds that Arf1 affected Myt1 activity for cyclin B1/CDK1‐based G2/M transition, which disturbed oocyte meiotic resumption. Besides, Arf1 modulated GM130 for the dynamic changes in the Golgi apparatus and Rab35‐based vesicle transport during meiosis. Moreover, Arf1 is associated with Ran GTPase for TPX2 expression, further regulating the Aurora A–polo‐like kinase 1 pathway for meiotic spindle assembly and microtubule stability in oocytes. Further, exogenous Arf1 mRNA supplementation can significantly rescue these defects. In conclusion, results reported the noncanonical functions of Arf1 in G2/M transition and meiotic spindle organization in mouse oocytes.
ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression
Authors: Wu Xuanhui , Wang Yong , Chen Bingyi , Liu Yongbo , Li Fang , Ou Yangjing , Zhang Haiwei , Wu Xiaoxia , Li Xiaoming , Wang Lingxia , Rong Wuwei , Liu Jianling , Xing Mingyan , Zhao Xiaoming , Liu Han , Ge Lingling , Lv Ankang , Wang Lan , Wang Zhichao , Li Ming , Zhang Haibing 
Published: November 2023

AbstractA20‐binding inhibitor of NF‐κB activation (ABIN1) is a polyubiquitin‐binding protein that regulates cell death and immune responses. Although Abin1 is located on chromosome 5q in the region commonly deleted in patients with 5q minus syndrome, the most distinct of the myelodysplastic syndromes (MDSs), the precise role of ABIN1 in MDSs remains unknown. In this study, mice with a mutation disrupting the polyubiquitin‐binding site (Abin1Q478H/Q478H) is generated. These mice develop MDS‐like diseases characterized by anemia, thrombocytopenia, and megakaryocyte dysplasia. Extramedullary hematopoiesis and bone marrow failure are also observed in Abin1Q478H/Q478H mice. Although Abin1Q478H/Q478H cells are sensitive to RIPK1 kinase–RIPK3–MLKL‐dependent necroptosis, only anemia and splenomegaly are alleviated by RIPK3 deficiency but not by MLKL deficiency or the RIPK1 kinase‐dead mutation. This indicates that the necroptosis‐independent function of RIPK3 is critical for anemia development in Abin1Q478H/Q478H mice. Notably, Abin1Q478H/Q478H mice exhibit higher levels of type I interferon (IFN‐I) expression in bone marrow cells compared towild‐type mice. Consistently, blocking type I IFN signaling through the co‐deletion of Ifnar1 greatly ameliorated anemia, thrombocytopenia, and splenomegaly in Abin1Q478H/Q478H mice. Together, these results demonstrates that ABIN1(Q478) prevents the development of hematopoietic deficiencies by regulating type I IFN expression.
Functional Connectivity Alterations and Molecular Characterization of the Anterior Cingulate Cortex in Tinnitus Pathology without Hearing Loss
Authors: Fan Ting , Guan Peng‐Fei , Zhong Xiao‐Fang , Xiang Meng‐Ya , Peng Ying‐Qiu , Zhou Ruo‐Qiao , Gong Jia‐Min , Zheng Yu‐Qing , Dai A‐Qiang , Feng Jia‐Ling , Yu Hong‐Zhe , Li Jian , Li Hua‐Wei , Wang Yun‐Feng 
Published: November 2023

AbstractCompared with individuals with hearing loss, tinnitus patients without hearing loss have more psychological or emotional problems. Tinnitus is closely associated to abnormal metabolism and function of the limbic system, a key brain region for emotion experience, but the underlying molecular mechanism remains unknown. Using whole‐brain microvasculature dynamics imaging, the anterior cingulate cortex (ACC) is identified as a key brain region of limbic system involve in the onset of salicylate‐induced tinnitus in mice. In the tinnitus group, there is enhanced purine metabolism, oxidative phosphorylation, and a distinct pattern of phosphorylation in glutamatergic synaptic pathway according to the metabolome profiles, quantitative proteomic, and phosphoproteomic data of mice ACC tissue. Electroencephalogram in tinnitus patients with normal hearing thresholds show that the functional connectivity between pregenual anterior cingulate cortex and the primary auditory cortex is significantly increased for high‐gamma frequency band, which is positively correlated with the serum glutamate level. These findings indicate that ACC plays an important role in the pathophysiology of tinnitus by interacting with the primary auditory cortex and provide potential molecular targets in the ACC for tinnitus treatment.
Interrelation Between External Pressure, SEI Structure, and Electrodeposit Morphology in an Anode‐Free Lithium Metal Battery
Authors: Liu Wei , Luo Yiteng , Hu Yuhang , Chen Zidong , Wang Qiang , Chen Yungui , Iqbal Naseem , Mitlin David 
Published: November 2023

AbstractThe interrelation is explored between external pressure (0.1, 1, and 10 MPa), solid electrolyte interphase (SEI) structure/morphology, and lithium metal plating/stripping behavior. To simulate anode‐free lithium metal batteries (AF‐LMBs) analysis is performed on “empty” Cu current collectors in standard carbonate electrolyte. Lower pressure promotes organic‐rich SEI and macroscopically heterogeneous, filament‐like Li electrodeposits interspersed with pores. Higher pressure promotes inorganic F‐rich SEI with more uniform and denser Li film. A “seeding layer” of lithiated pristine graphene (pG@Cu) favors an anion‐derived F‐rich SEI and promotes uniform metal electrodeposition, enabling extended electrochemical stability at a lower pressure. State‐of‐the‐art electrochemical performance is achieved at 1MPa: pG‐enabled half‐cell is stable after 300 h (50 cycles) at 1 mA cm−2 rate −3 mAh cm−2 capacity (17.5 µm plated/stripped), with cycling Coulombic efficiency (CE) of 99.8%. AF‐LMB cells with high mass loading NMC622 cathode (21 mg cm−2) undergo 200 cycles with a CE of 99.4% at C/5‐charge and C/2‐discharge (1C = 178 mAh g−1). Density functional theory (DFT) highlights the differences in the adsorption energy of solvated‐Li+ onto various crystal planes of Cu (100), (110), and (111), versus lithiated/delithiated (0001) graphene, giving insight regarding the role of support surface energetics in promoting SEI heterogeneity.
Low‐Friction Graphene Oxide‐Based Ion Selective Membrane for High‐Efficiency Osmotic Energy Harvesting
Authors: Wang Dejuan , Wang Zequn , Chen Jialin , Zhi Hui , Liu Yongxu , Tang Jiebin , Li Ningbo , Zhang Yafang , An Meng , Liu Hong , Xue Guobin 
Published: November 2023

AbstractGraphene‐based laminate membranes with selective ion‐transport capability show great potential in renewable osmotic energy harvesting. One of the great challenges is to reduce the overall energy barriers while remain the high ion selectivity in the transmembrane ion transport process. Here, a strategy is proposed to break the trade‐off between ion selectivity and permeability in laminar nanochannels using amphiphilic molecules as modifier, which enhances the surface charge density of nanochannel by loading more ion polymer with polar head and lows the frictional force of ion transport with hydrophobic tail. The conversion efficiency can reach to 32% in osmotic energy harvesting (0.5 m/0.01 m concentration gradient) after adopting this modifier. During the process of mixing real river water and seawater, the maximum power density can reach to 13.38 W m−2. The amphiphilic molecules also bind adjacent nanosheets, endowing the membrane's strong mechanical strength and high stability in aqueous solution. This work can open up a new way to regulate the transmembrane ion transport in 2D laminate membranes.