bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les couvertures du second Moyen Âge en Alsace : un état des connaissances
Authors: Werlé Maxime , Kill René , Schwien Jean-Jacques 
Published: January 2024

L’Alsace médiévale a principalement connu trois types de matériaux de couverture, employés sous des formes diverses et de façon concomitante : le chaume, le bois et la terre cuite. La présente contribution vise à dresser un état des connaissances sur l’emploi de chacun de ces matériaux. La période considérée, du xiie au xvie siècle, est marquée par quelques évolutions majeures, nullement linéaires au plan chronologique et géographique : 1° la réapparition aux xiie-xiiie siècles des couvertures en terre cuite dans un paysage jusqu’alors largement dominé, pour ce que l’on peut en percevoir, par les couvertures en chaume et en bois ; 2° le développement de la production de tuiles creuses à crochet, qui s’impose durablement dans les villes dès les xive-xve siècles, au détriment des autres matériaux de couverture ; 3° a contrario, le maintien en contexte rural, villageois et castral, des couvertures en chaume et en bois bien au-delà du Moyen Âge ; 4° l’apparition et le développement sans précédent, dans la première moitié du xvie siècle, de couvertures en tuiles plates en écaille (au détriment cette fois des anciennes tuiles creuses dont la production devient marginale). La démonstration, notamment fondée sur des données issues de fouilles et d’études archéologiques du bâti, mais aussi sur l’exploitation des sources écrites et iconographiques, cherchera à préciser les étapes chronologiques de ces évolutions et à déterminer les raisons de ces changements.
« Flesh for Fantasy » ? Expressions musico-visuelles de la masculinité dans les clips de hard rock et de heavy metal des années 1980
Authors: Gaudin Antoine 
Published: January 2024

En tant que défilé permanent de corps engagés dans des performances spectaculaires qui sont aussi d’intensives performances de genre, le secteur du clip constitue une scène privilégiée pour la construction et la négociation des identités culturelles associées aux genres. Centré sur la question des masculinités, cet article prend pour objet le vaste corpus des vidéos de hard rock et de heavy metal multi-diffusés dans la première décennie de MTV. Quelles expériences musico-visuelles ces clips proposaient-ils à leurs audio-visionneur·ses ? Quels rapports entre hommes et femmes mettaient-ils en scène ? En quoi contribuent-ils à éclairer certaines façons de se définir en tant qu’homme dans le contexte social, politique et médiatique des années 1980 ? Derrière la reconduction de certains stéréotypes sexuels (et le détournement de certains autres), que nous communiquent ces objets audiovisuels sur la construction d’un sujet masculin peut-être plus ambigu qu’il n’y paraît ?
RESISTÊNCIA INDÍGENA E REPRESSÃO INQUISITORIAL
Authors: Cavalcante Paiva Alan Abel , Santos da Cruz Remo 
Published: January 2024

O presente artigo tem como objetivo analisar fontes inquisitoriais envolvendo três indígenas moradores da capitania do Rio Grande acusados de portarem bolsas de mandinga. Com base nas referidas fontes, pretende-se compreender as supostas origens dos referidos objetos, seus elementos de apropriação e a transformação cultural pela qual estes passaram na América Portuguesa. Em seguida, serão levantadas hipóteses e interpretações para os casos supracitados levando em consideração as discussões acerca da atuação do Santo Ofício, o papel ativo dos povos indígenas no âmbito da sociedade colonial e os processos de resistência protagonizados por esses. Por fim, o presente trabalho busca, também, problematizar os estigmas, contidos nestas fontes inquisitoriais, a respeito das populações indígenas durante o período colonial.
Indicators sand flies and environment associated to spatial landscaping change in Choco Biosphere Reserve UNESCO
Authors: Enríquez Sandra , Arrivillaga-Henríquez Jazzmín , Duque Paul , Herrera Vanessa , Vaca Franklin , Sánchez Marco , Roldán Mateo , Ron-Garrido Lenin , Molina C Alfonso 
Published: January 2024

ABSTRACT

Background & objectives:
Sand flies are insects vector associated with terrestrial forest ecosystems; in the Ecuadorian Andes, they participate in the transmission of human cutaneous leishmaniasis. This geographical area is an opportunity to evaluate the role of sand flies as bioindicators od the degree of intervention of a tropical humid forest ecosystems (THF) associated with changes in the ecology of the local landscape.

Methods:
CDC-light traps were used for collecting adults’ sand flies in February 2020 in a humid tropical forest within Choco Biosphere Reserve. All species were identified using morphological keys. Analysis data about abundance, richness, species accumulation, diversity index, species composition communities, species sex proportion, spatial sand flies environmental, Renyi’s Diversity Profile were performed to compare six spatial habitats in Mashpi locality, Ecuador.

Results:
Sand flies were collected (n-1435); the main species are represented by Th. reburra Ny. trapidoi, Pa. aclydifera, Py. panamensis and Lu. hartmanni. Only Th. reburra is associated with not intervened forest, while the other 3 species are associated with intervened forest within Mashpi in the Choco Biosphere Reserve. The secondary forest has the major sandflies’ richness, while the primary forest exhibits the major abundance.

Interpretation & conclusion:
The results indicated that Th. reburra is a sandfly restricted to the Andean Forest and is a bioindicator of the high environmental health quality of the forest, while Ny. trapidoi and Pa. aclydifera are bioindicators of environmental disturbances in the forest. Additionally, Ps. panamensis, Lu. hartmanni and Ny. trapidoi are bioindicators of human impact and the risk of leishmaniasis.
Secondary infections in COVID-19: Antemortem and postmortem culture study
Authors: Kiro Vandana V. , Sharma Meenakshi , Srivastava Sharad , Lalwani Parin , Aggarwal Richa , Soni Kapil D. , Malhotra Rajesh , Lalwani Sanjeev , Mathur Purva , Trikha Anjan 
Published: January 2024

ABSTRACT

Background:
Secondary bacterial infections during COVID-19 hospitalization have been reported in about 6–15% of patients.

Aims:
To study the secondary bacterial infections that affected the COVID-19 patients during their hospitalisation and to unearth the bacteriological profile of samples obtained after their demise.

Settings and Design:
This prospective study was carried out at a COVID-19 dedicated, apex tertiary care centre in North India from July 2020 to April 2021.

Methods and Material:
Samples of 268 patients were considered for the study. Nasopharyngeal swab specimen, blood, and tissue (lung) were collected from the deceased body as early as possible and processed.

Statistical Analysis:
Statistical analyses were performed using STATA version 11.1 (Stata Corp., College Station, TX, USA).

Results:
A total of 170 samples were received from patients before their death, which included blood, urine, respiratory samples, pus, and cerebrospinal fluid. Forty-four pathogens were isolated, which consisted of Acinetobacter baumannii (43.1%), Klebsiella pneumoniae (36.3%), Escherichia coli (11.3%), and Pseudomonas aeruginosa (4.5%), Enterococcus faecium (4.5%). Two hundred fifty-eight samples were collected from the deceased bodies wherein the nasopharyngeal sample was highest, followed by tissue and blood. A total of 43 pathogens were isolated among them which included A. baumannii (44.1%), followed by K. pneumoniae (25.5%), E. coli (20.9%), P. aeruginosa (6.97%) and Enterobacter cloacae (2.3%). All these isolates were highly resistant to antimicrobials.

Conclusions:
In our study, bacterial profiles in antemortem and postmortem samples were found to be similar, suggesting that resistant pathogens may be the cause of mortality in COVID-19 infected hospitalised patients.
Endocrine mucin-producing sweat gland carcinoma of the eyelid – A diagnostic challenge
Authors: Bhanvadia Viral M. , Kathiara Ravija , Shah Ami , Asari Wilhemina 
Published: January 2024

ABSTRACT
Skin adnexal or sweat gland neoplasms are rare adnexal tumors that pose a diagnostic challenge for both ophthalmologists and pathologists. Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is an uncommon low grade carcinoma of eccrine ducts with a predilection to occur in the periocular region in the elderly female. We present a rare case of 65-year-old healthy male who presented with a lobulated mass in the left eye lower lid, clinically suspected as sebaceous gland carcinoma, diagnosed as endocrine mucin-producing sweat gland carcinoma histopathologically.
Upregulated LncRNA-LINC00659 expression by H. pylori infection promoted the progression of gastritis to cancer by regulating PTBP1 expression
Authors: Zhang Jiani , Zhang Zhengbo , Shen Danlei 
Published: January 2024

ABSTRACT

Context:

Helicobacter pylori (H. pylori), a spiral-shaped bacterium, is closely associated with chronic, progressive gastric mucosal damage, gastric atrophy, and even gastric cancer (GC). An increasing number of studies have addressed the correlation between long noncoding RNAs (lncRNAs) and H. pylori pathogenicity in GC.

Objective:
In this study, we found that the expression level of LINC00659 gradually increased in the progression from atrophic gastritis, intestinal metaplasia, and dysplasia to GC in H. pylori-infected patients. Thus, we aimed to further explore the function of LINC00659 in the progression of gastritis to cancer under H. pylori infection.

Materials and Methods:
StarBase predictions, ribonucleic acid (RNA)-binding protein immunoprecipitation assays, and gene ontology functional annotation (GO)/Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis were performed to identify the RNA-binding proteins of LINC00659; moreover, qRT‒PCR, western blotting, RNA interference, and immunofluorescence assays were used to investigate the function of LINC00659.

Results:
LINC00659 bound directly to the RNA-binding protein polypyrimidine tract-binding protein (PTBP1). Importantly, qRT‒PCR and western blot assays demonstrated that PTBP1 expression increased in the progression from inflammation to cancer in the stomach of H. pylori-infected patients and H. pylori-infected GES-1 cells. However, LINC00659 knockdown downregulated PTBP1 expression and inhibited PTBP1 binding under H. pylori infection. Finally, LINC00659 knockdown significantly reduced H. pylori-induced human gastric epithelial cell senescence and suppressed interleukin (IL)-6 and IL-8 secretion by reducing the phosphorylation level of NF-κB p65.

Conclusions:
This study indicated that LINC00659 may have the potential to be a novel promising prognostic and therapeutic marker for H. pylori-associated gastric diseases.
Rosai Dorfman Disease with malignant transformation to Histiocytic Sarcoma: A diagnostic conundrum
Authors: Thakur Shilpi , Abraham Reema M. , Pushpam Deepam , Ahmed Shamim , Mallick Saumyaranjan 
Published: January 2024

ABSTRACT
Histiocytic disorders mostly occur as de-novo nodal or extranodal benign masses with rare secondary malignant transformation. A 10-year-old female presented with 10-cm cervical swelling since 9 months associated with fever. Computed tomography revealed left cervical lymphadenopathy and bilateral lung nodules. Lymph node excision biopsy showed effacement of architecture by atypical histiocytes with marked nuclear pleomorphism and frequent mitosis. Focal areas showed mature histiocytes with emperipolesis. The cells were immunopositive for CD68, CD163, and S100 (focal), whereas they were negative for Langerin and CD1a. The Ki67 proliferative index was 30%. A diagnosis of histiocytic sarcoma in a background of Rosai-Dorfman disease was made.
Incidence of Coronavirus-2 in cerebrospinal fluid in pregnant Coronavirus Disease 2019 (COVID-19) patients with neurological symptoms
Authors: Akdeniz Sevda , Taskin Mehmet Hakan , Oruc Muhammet Ali , Caliskan Canan Soyer , Celik Samettin 
Published: January 2024

ABSTRACT

Background:
The aim of this prospective cohort study was to investigate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the cerebrospinal fluid (CSF) of pregnant women with neurological symptoms due to coronavirus disease 2019 (COVID-19).

Materials and Methods:
This research was carried out in the Samsun University. Department of Anesthesiology and Reanimation from December 2021 to May 2022. Pregnant women exhibiting neurological symptoms linked to COVID-19 were assigned to one of the two groups, depending on the severity of the disease–mild (Group 1) and severe (Group 2). Specimens were collected from patients’ CSF, and the presence of SARS-CoV-2 was investigated using the reverse transcription-polymerase chain reaction (RT-PCR) method. SARS-CoV-2 was also investigated using RT-PCR by collecting oropharyngeal swab specimens from infants in the first 6 h after birth.

Results:
One hundred fifty patients were enrolled, 75 in both groups. The most frequent neurological symptoms were dizziness in Group 1 (52%) and headache in Group 2 (32%). No significant differences were determined in neutrophils, lymphocytes, hemoglobin, leukocytes, platelets, ferritin, D-dimer, C-reactive protein, prothrombin time, aspartate aminotransferase, alanine aminotransferase, creatinine, sedimentation, or fibrinogen values. SARS-CoV-2 was identified in the CSF of only one patient, from Group 2. Infant oropharyngeal swab specimens tested negative for SARS-CoV-2 using RT-PCR.

Conclusion:
This study indicates that the detection of SARS-CoV-2 in CSF via RT-PCR is rare. We suggest that neurological symptoms linked to SARS-CoV-2 are not caused by direct invasion and that other etiologies represent more likely mechanisms.
Clinicopathological features of two ultra-rare cases of malignant perivascular epithelioid cell tumors (PEComas) involving the uterus with recent updates
Authors: Rekhi Bharat , Menon Santosh 
Published: January 2024

ABSTRACT
Malignant perivascular epithelioid tumors (PEComas) involving the uterus are uncommon. Herein, we present the clinicopathological features of two such cases, including their diagnostic implications with recent updates. A 62-year-old lady presented with vaginal bleeding. Ultrasonogram revealed a heterogeneous uterine mass. She underwent an endometrial biopsy and total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO), which revealed a 3.2 cm-sized proliferative tumor in the fundus. A 45-year-old lady presented with recurrent abdominal pain. She underwent cytoreductive surgery twice with adjuvant chemotherapy for multiple tumors and TAH-BSO for a uterine tumor, 2 years before. Microscopic examination of both tumors revealed markedly atypical, polygonal-shaped/epithelioid tumor cells containing eosinophilic cytoplasm and arranged in a nesting pattern with intervening thin-walled blood vessels, mitotic figures (≥ 6/10 high power fields (hpfs)), and tumor necrosis. Tumor infiltration was more than half the myometrial thickness in the first tumor and pelvic nodal metastasis. The second tumor revealed rhabdoid-like and vacuolated cells along with “spider-like” giant cells. Immunohistochemically, both the tumors were positive for HMB45 and desmin, while negative for epithelial markers. Additionally, the second tumor was positive for smooth muscle actin (SMA) and TFE3. Both patients developed tumor recurrences. In view of multiple tumor deposits, the second patient was induced with a mammalian target of rapamycin (m-TOR) inhibitor (everolimus) but unfortunately died of the disease. Malignant PEComas involving the uterus are ultra-rare, aggressive tumors. An index of suspicion, based on certain histomorphological features, supported by immunohistochemical expression of myomelanocytic markers is necessary for a correct diagnosis. Certain PEComas display TFE3 positivity. A correct diagnosis has significant implications, including an aggressive clinical course and the possibility of targeted therapy, especially in recurrences or metastasis.
A Cross-Sectional Survey to Assess Awareness and Perception to Clinical Research: Unbox Research
Authors: Sharma Pooja , Aggarwal Rhea , Mittal Niti , Chougule Durga , Bhalla Ritu , Kapoor Deeksha , Chauhan Kuldeep Kumar , Singh Padam , Singh Manish Kumar 
Published: January 2024

ABSTRACT

Background:
The boom in clinical research/clinical trials (CR/CT) has generated valuable knowledge in the field of medical science. India has been a promising CT sector, but witnesses’ only modest involvement from participants. The lack of awareness is possibly one of the factors that has led to stagnated growth of this sector.

Objective:
To assess the awareness and perception of participants to CR/CT and their willingness to participate.

Methods:
A cross-sectional online survey with a questionnaire comprising 25 questions. The survey was implemented at secondary and higher secondary schools, colleges/institutes as well as patient advocacy group.

Results:
A total of 852 participants participated in the online survey having median age 21 (Interquartile range: 20–28) years. More than 85% of participants were aware of CR/CT. The source of information was majorly contributed by hospitals (44.2%), social media (40.2%), and print media (40.2%). The perception about CT was reported as possibility of new treatment (63.4%) and more useful than traditional treatment (52.5%). More than half of the participants were willing to participate in CR involving questionnaire surveys (39.2%), research done together with administration of standard medical care (3.7%), and single blood draw/visit (34.7%). The survey reflected an unwillingness to participate in CR/CT due to concerns about safety (59.7%) and fear (50.8%).

Conclusion:
This survey showed that there has been increasing awareness and willingness to participate in CR/CT. However, to increase the participation, there is a need to address the concerns of safety and fear.
Evaluating the evidence for a liver shrinkage diet for obese patients prior to laparoscopic cholecystectomy: A systematic review and meta-analysis
Authors: Hughes Daniel Llwyd , Elmasry Mohamed , Wilson Iain , El Kafsi Jihène 
Published: January 2024

Background:
The role of a very low-calorie diet (VLCD) before cholecystectomy in obese patients is unclear. This study evaluated whether VLCD could be used as a risk mitigation strategy for this high-risk patient cohort.

Patients and Methods:
A systematic review and meta-analysis was performed (PROSPERO ID CRD42022374610). The primary outcome was to determine the impact of pre-operative VLCD on the operative findings and ease of dissection during laparoscopic cholecystectomy (LC).

Results:
Two studies were included with a total of 84 patients. VLCD was associated with a significantly easier Calot’s dissection (MD: −0.58 (95% confidence interval [CI] [ −1.03, -0.13], P = 0.01) and was associated with a significantly higher rate of pre-operative weight loss (MD; 2.92 (95% CI [2.23, 3.62], P = 0.00001).

Conclusions:
The published evidence regarding VLCD before cholecystectomy in obese patients is limited. After acknowledging the limitations of the data, VLCD is associated with a significantly higher rate of weight loss preoperatively and directly impacts the ease of intraoperative dissection of Calot’s triangle. Routine use of VLCD should be considered for all obese patients undergoing elective LC.
Totally laparoscopic partial splenectomy and gastropexy for a splenic cyst in a wandering spleen
Authors: Merchant Taher Saifuddin , Kotawala Hussain 
Published: January 2024

Abstract
With only seven reported cases until 2019 as noted by Lim et al., cases of a wandering spleen (WS) accompanied by splenic cyst (SC) are exceptionally rare. Furthermore, both entities are notoriously ‘silent’ until they present as an emergency with complications, often warranting total splenectomy. Management of SC in a WS eventually depends on its clinical presentation, disease type and functional reservoir of the spleen. However, it is desirable to operate electively and perform a spleen salvage with splenic reposition surgery. Our case describes the first totally laparoscopic partial splenectomy and intraperitoneal fixation of the spleen by means of gastropexy for a large non-parasitic SC in a WS. Partial splenectomy instead of just a cystectomy tackles the risk of cyst recurrence, and a gastropexy over other splenic repositioning techniques would allow the spleen to remain as an intraperitoneal organ.
Is the double-ligation method safe and effective in laparoscopic paediatric inguinal hernia repair? A retrospective cohort study
Authors: Yun Jong Hyuk , Son Myoung Won , Song Geum Jong , Lee Moon-Soo 
Published: January 2024

Abstract

Introduction:
Laparoscopic paediatric hernia repair has since been performed more frequently. Recently, a double-ligation method was introduced to prevent recurrence in laparoscopic surgery. The objective of our study was to compare the postoperative outcomes of patients who underwent double and single ligations.

Patients and Methods:
We performed a retrospective review of patients with inguinal hernia who underwent laparoscopic paediatric inguinal hernia repair from 2014 to 2018 at our institution. Patients were divided into two groups and underwent single ligation and double ligation.

Results:
Three hundred and six patients (single-ligation group: 142 and double-ligation group: 164) were included. Four patients experienced recurrence, and the recurrence rate was 1.29%. The recurrence rate was significantly higher in the single-ligation group. There were no statistically significant differences in the postoperative complications between the two groups.

Conclusion:
Double-ligation method in laparoscopic paediatric hernia repair was relatively safe and helpful.
First ever reported case of right-sided rupture of eventration of the diaphragm: Thoraco-laparoscopic approach
Authors: Gupta Priya , Wani Sachin , Kalikar Vishakha , Patankar Roy 
Published: January 2024

Abstract
Diaphragmatic eventration (DE) is an abnormal condition where a portion or the entire hemidiaphragm elevates due to insufficient muscle or nerve function while maintaining its anatomical attachments. On the other hand, congenital diaphragmatic hernias occur due to the abnormal development of muscular entities of the diaphragm, resulting in the displacement of abdominal contents into the thorax. The difference between diaphragmatic hernia and eventration is important as there is no true defect in DE. Ruptured eventration of the diaphragm is a rare entity, with only three cases reported in adults in literature till date, all on the left side. We report the first case of ruptured eventration of the diaphragm on the right side, which was repaired by a combination of laparoscopy and thoracoscopy and with double-mesh placement.