bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distributional patterns and habitat association of sympatric carnivores in Margalla Hills National Park, Pakistan, and a comparison of conventional versus molecular identification in carnivore scatology
Authors: Fatima Hira , Mahmood Tariq , Hennelly Lauren M. , Farooq Muhammad , Munawar Nadeem , Ali Waqas , Sacks Benjamin N. 
Published: October 2023

Abstract
Knowledge of a species’ distribution is important for developing effective conservation programs. In Pakistan, little is known about the status or distribution of most carnivores coexisting in the same landscape. To address this knowledge gap, we studied distribution patterns of coexisting carnivores in Margalla Hills National Park, using both conventional as well as DNA-identified scats, and other signs. Although scat surveys remain a popular approach to study carnivores, scat identification based on morphology alone is error-prone. As part of our study, we therefore evaluated accuracy of morphological identification of scats using genetic techniques. Field surveys were conducted from September 2015 to December 2018. Using 593 direct (sighting, camera trapping, road kills) and indirect (scats, footprints) field signs, we detected total 11 carnivore species in the park, including 10 that were represented in the subset of 248 (47.7%) scats identified from DNA. The molecular analyses confirmed that the misidentification rate was highest for red fox (Vulpes vulpes) (8.47%), followed by Asiatic jackal (Canis aureus) (7.66%), but least for small Indian civet (Viverricula indica) (3.63%). For investigating habitat association of carnivores, and to test for the associations between species presence and Normalized Difference Vegetation Index (NDVI), we compared the mean and standard deviation of NDVI of each species’ presence locations with the mean and standard deviation of NDVI along the 23 sampling transects. Based on DNA-verified and all scats, carnivore species showed a range of mean NDVI, suggesting, preliminarily, some species may utilize a greater diversity of habitat types than others.
Hysteroscopic suture of levonorgestrel-releasing intrauterine system: learning curve for in vitro simulation training
Authors: Huang JinCheng , Zhang WenJian , Tang Kun , Liu XiaoMei , Tian ZengSai , Li CuiFen , Jiang SuZhen 
Published: October 2023

Objective To simulate hysteroscopic suturing in vitro and analyze the learning curve of gynecologists with different experience levels. Methods Three gynecologists were trained on uterine models in a circulating water box. The posterior uterine wall was sutured 10 times under hysteroscopy for 5 consecutive days, and the time of each suture procedure was recorded. Results Doctors A, B, and C completed 50 posterior uterine sutures. After Dr. C completed 50 sutures on the posterior wall, he added 50 sutures on the anterior wall (Group D). The mean suturing time was 71.54 ± 68.158 s in Group A, 50.10 ± 28.060 s in Group B, 34.04 ± 10.457 s in Group C, and 30.38 ± 8.734 s in Group D. The difference between Groups C and B and between Groups B and A was statistically significant. There was no statistically significant difference between Groups C and D. Simulation curves were created using the number of features as the abscissa and cumulative sum as the coordinate, with peak curves of 19, 27, and 18 cases for Group A, B, and C, respectively. Conclusion Doctors with experience in single-hole laparoscopic surgery or hysteroscopic suture surgery can significantly shorten the hysteroscopic suturing time.
Canagliflozin and irbesartan ameliorate renal fibrosis via the TGF-β1/Smad signaling pathway in Dahl salt-sensitive rats
Authors: Zhai Jianlong , Wang Zhongli , Zhang Tingting , He Lili , Ma Sai , Zuo Qingjuan , Zhang Guorui , Wang Xinyu , Guo Yifang 
Published: October 2023

Objectives This study assessed the antifibrotic effects of canagliflozin, with or without irbesartan, on renal injury in Dahl salt-sensitive (SS) rats fed a high-salt (HS) diet. Methods After the preconditioning stage, Dahl SS rats (n = 47) were divided into five experimental groups as follows: low-salt (LS, n = 7), HS (n = 10), HS with canagliflozin (n = 10), HS with irbesartan (n = 10), and HS with canagliflozin and irbesartan (n = 10). Results The HS diet increased systolic blood pressure (SBP), renal fibrosis, fibrotic protein expression, and transforming growth factor-β1 (TGF-β1)/Smad2/3 pathway protein expression compared with the findings in the LS group. Irbesartan reduced SBP and slowed the loss of renal function. Canagliflozin significantly reduced body weight and renal fibrosis and suppressed the TGF-β1/Smad2/3 pathway. The combined therapy exerted better renoprotective effects on all outcome parameters. Conclusions These results indicate that canagliflozin and irbesartan exert different effects on renal injury in SS hypertensive rats, and the combined regimen could have stronger effects than either monotherapy.
The Violence of Settler Imperialism – and Why the Concept of Coloniality Cannot Grasp It
Authors: Rosenow Doerthe 
Published: October 2023

Against a background of ongoing public and academic debate about how to best address the legacies of colonialism and slavery, there is now an ever-expanding body of International Relations (IR) literature that makes use of the concept of ‘coloniality’. Indeed, coloniality, which attempts to make sense of past and ongoing colonial oppression in global terms, seems a particularly apt concept for IR, which, after all, is interested in understanding the nature of global power. This article is critical of the way that coloniality is increasingly used in a unitary ‘catch-all’ manner to describe global colonial domination in often unspecific ways. It argues, based on an in-depth exegesis of key Latin American decolonial texts, that the way the concept has been developed makes certain colonial violence, and the resistance against it, invisible; with the violence of (global) settler colonialism being a prominent example. Using and further developing Jodi Byrd’s concepts of transit and settler imperialism, in dialogue with Latin American settler colonial literature and radical Black thought, this article aims to bring this violence to the forefront of IR debate. I will conclude by elaborating on the concrete consequences that understanding ongoing colonial violence with the help of these concepts has for thinking about decolonisation in IR. La violence de l’impérialisme colonial, et pourquoi le concept de colonialité ne peut l’appréhender
Social Support From Family and Friends, Educational Attainment, and Cognitive Function
Authors: Moorman Sara M. , Pai Manacy 
Published: October 2023

This study assessed the extent to which associations between perceived and received social support from family and friends and changes in older adults’ cognitive function were moderated by educational attainment. Sibling pairs in the Wisconsin Longitudinal Study (WLS) ( N = 4,297) completed a survey about social support in 2011 and a cognitive battery in 2011 and 2020. Participants’ mean age in 2020 was 80.2 years old. Multilevel linear regressions indicated that perceived, but not received, support from friends was associated with better cognitive function 9 years later. Perceived family support was cognitively advantageous for older adults at most levels of educational attainment. However, among postgraduates, perceived family support was unrelated to cognitive function. That the association between perceived support and cognitive function differs based on educational attainment gives interventionists additional information needed to identify groups of older adults most susceptible to cognitive impairment.
Loneliness Among Older Indian Workers: Findings From the Longitudinal Ageing Study in India
Authors: Shankar Aparna , Ravi Chaitanya 
Published: October 2023

The number of adults aged 60 years and over who work is growing. However, there has been relatively limited research assessing the determinants of wellbeing in this cohort. Given the known relationship between loneliness and socioeconomic disadvantage, the present analysis assessed the role of working conditions and food security on loneliness among employed Indians aged 60 years and over ( N = 9035), using data from wave 1 of the Longitudinal Ageing Study in India. Just over 11% of participants reported being lonely most or all of the time. Food insecurity and work that involved exposure to unpleasant conditions was associated with increased loneliness, while work requiring more mental effort was associated with lower loneliness. Policies that ensure skills training to support job transitions for older adults working in unpleasant conditions, and greater food security in later life are important to ensure wellbeing in this group.
Disease-modifying effect and long-term safety of belimumab in patients with systemic lupus erythematosus: A single-center retrospective study
Authors: Nakai Takehiro , Fukui Sho , Sawada Haruki , Ikada Yukihiko , Tamaki Hiromichi , Kishimoto Mitsumasa , Okada Masato 
Published: October 2023

Background Disease modification in systemic lupus erythematosus (SLE) is important for minimizing disease activity while limiting treatment-associated toxicities. Belimumab can be used as a remission-induction/maintenance systemic lupus erythematosus therapy; however, its disease-modifying effects are unclear. We aimed to determine these effects in patients with systemic lupus erythematosus. Methods This single-center retrospective cohort study included 92 patients with systemic lupus erythematosus treated with belimumab. We analyzed the changes in flare free rate/lupus low disease activity state (LLDAS) attainment rate/glucocorticoid dosage/Systemic Lupus International Collaborating Clinics and American College of Rheumatology damage index (SDI) score/drug retention rate after treatment initiation. Results Fifty-two weeks after initiating belimumab, the flare rate decreased from 82.6% to 14.1% ( p < .01). Until week 52 and 1000 days after initiating belimumab treatment, > 70% and ∼90% of the patients attained lupus low disease activity state, respectively. Belimumab treatment significantly reduced glucocorticoid demand (initiation day, 8.88 (6.00–15.00) mg/d; week 52, 5.00 (2.00–7.00) mg/d; final day of the study period, 3.00 (0.46–6.06) mg/d, initiation day vs. week 52: p < .01, initiation day vs. final day: p < .01); at the end of the study period, 68.5% of patients required ≤5 mg/d prednisolone, and 22.8% discontinued glucocorticoids. Most patients were SDI progression-free (week 52, ∼95%; day 1000, ∼90%), and belimumab showed a high drug retention rate (week 52, 90%; day 1000 > 80%). Conclusion Most patients experienced lupus low disease activity state, reduced flare rate and glucocorticoid demand, and a stable SDI trend after belimumab treatment initiation. Given its efficacy and retention rate, belimumab treatment may serve as a fundamental strategy in disease modification.
Bacterial bloodstream infection in critically ill patients with COVID-19: a retrospective cohort study
Authors: Bartoszewicz Mateusz , Czaban Sławomir Lech , Bartoszewicz Klaudia , Kuźmiuk Damian , Ładny Jerzy Robert 
Published: October 2023

Background: Intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19), have a high risk of developing bloodstream infections (BSIs). However, the characteristics of and risk factors for BSIs in these patients remain unclear. Objective: We aimed to identify prevalent causative pathogens of BSI and related factors in critically ill patients with COVID-19. Design: This was a single-center, retrospective cohort study. Methods: We analyzed the clinical characteristics and outcomes of 201 ICU patients with COVID-19. Logistic regression analysis was conducted to identify factors associated with BSI occurrence. Furthermore, we identified the primary causative pathogens of BSIs. The study outcomes were death or ICU discharge. Results: Among the 201 included patients, 43 (21.4%) patients developed BSI. The mortality rate was non-significantly higher in the BSI group than in the BSI group (65.1% versus 58.9%, p = 0.487). There were significant between-group differences in the obesity prevalence and sex distribution, but not corticosteroid usage. BSI occurrence was significantly associated with duration of mechanical ventilation (MV), presence of ventilator-associated pneumonia, use of neuromuscular blocking agents, length of stay in ICU (ICU LOS), high body mass index (BMI), and male sex. The main causative pathogens were Klebsiella pneumoniae, Acinetobacter baumannii, and Enterococcus faecalis. Multi-drug-resistant pathogens were found in 87% of cases. Regardless of the origin, the common risk factors for BSI were ICU LOS and MV duration. All BSIs were acquired within the hospital setting, with ≈60% of the cases being primary BSIs. A small proportion of the BSI cases were catheter-related (four cases, 6.2%). Ventilator-associated pneumonia and urinary tract infections were present in 25% and 9.4% of the BSI cases, respectively. On average, the first positive blood culture appeared ≈11.4 (±9.7) days after ICU admission. Conclusion: Elucidating the risk factors for and common pathogens of BSI can inform prompt management and prevention of BSIs.
Self-regulatory coping among community dwelling older adults with multiple chronic conditions
Authors: Bankole Ayomide Okanlawon , Gill Sara L. , McSharry Jenny , White Carole L. , Aniemeke Chidinma , Wallington Sherrie Flynt , Addo-Mensah Dorothy Ewurabena , Braden Carrie Jo 
Published: October 2023

Objectives Many older adults with multiple chronic conditions (MCC) frequently experience hospitalizations, functional limitations, and poor quality of life. Outcomes may be improved by promoting self-regulation, which may individuals respond to health threats and manage their health conditions. The aim of this study was to describe self-regulatory coping among older adults with MCC. Methods A qualitative descriptive study using semi-structured interviews and content analysis and guided by the Common-Sense Self-Regulation Model. Seventeen community-dwelling older adults with two or more chronic conditions participated in our study. Results Three themes were developed from the analysis: (1) “I don’t think about it unless something happens": coping in the absence of a health event, (2) "doing what I am supposed to do”: coping during a health event, and (3) “How do I know if what I did works?”: appraisal of coping success. Discussion Self-regulatory coping was influenced by individual beliefs and experiences ( illness representations), context, self-efficacy and availability of support and resources to cope with MCC. These findings suggest implications for clinical practice and future self-regulation interventions for older adults with MCC.
Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
Authors: Shan Shidong , Su Min , Li Yan , Wang Zhen , Liu Daoquan , Zhou Yongying , Fu Xun , Yang Shu , Zhang Junchao , Qiu Jizhang , Liu Huan , Zeng Guang , Chen Ping , Wang Xinghuan , DiSanto Michael E. , Guo Yuming , Zhang Xinhua 
Published: October 2023

Abstract
Background
The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis. The role of RhoA in BPH remains unclear.

Methods
This study aimed to clarify the expression, functional activity and mechanism of RhoA in BPH. Human prostate tissues, human prostate cell lines, BPH rat model were used. Cell models of RhoA knockdown and overexpression were generated. Immunofluorescence staining, quantitative real time PCR (qRT-PCR), Western blotting, cell counting kit-8 (CCK-8), flow cytometry, phalloidine staining, organ bath study, gel contraction assay, protein stability analysis, isolation and extraction of nuclear protein and cytoplasmic protein were performed.

Results
In this study we found that RhoA was localized in prostate stroma and epithelial compartments and was up-regulated in both BPH patients and BPH rats. Functionally, RhoA knockdown induced cell apoptosis and inhibited cell proliferation, fibrosis, epithelial-mesenchymal transformation (EMT) and contraction. Consistently, overexpression of RhoA reversed all aforementioned processes. More importantly, we found that β-catenin and the downstream of Wnt/β-catenin signaling, including C-MYC, Survivin and Snail were up-regulated in BPH rats. Downregulation of RhoA significantly reduced the expression of these proteins. Rho kinase inhibitor Y-27632 also down-regulated β-catenin protein in a concentration-dependent manner. However, overexpression of β-catenin did not affect RhoA-ROCK levels, suggesting that β-catenin was the downstream of RhoA-ROCK regulation. Further data suggested that RhoA increased nuclear translocation of β-catenin and up-regulated β-catenin expression by inhibiting its proteasomal degradation, thereby activating Wnt/β-catenin signaling. Overexpression of β-catenin partially reversed the changes in cell growth, fibrosis and EMT except cell contraction caused by RhoA downregulation. Finally, Y-27632 partially reversed prostatic hyperplasia in vivo, further suggesting the potential of RhoA-ROCK signaling in BPH treatment.

Conclusion
Our novel data demonstrated that RhoA regulated both static and dynamic factors of BPH, RhoA-ROCK-β-catenin signaling axis played an important role in the development of BPH and might provide more possibilities for the formulation of subsequent clinical treatment strategies.
Profiling risk factors for separation of infection complications in patients with gastrointestinal and nodal diffuse large B-cell lymphoma
Authors: Xue Min , Gao Zhenzhen , Yan Miaolong , Bao Yi 
Published: October 2023

Abstract
Objective
To identify risk factors for infection complications in patients with gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) and nodal DLBCL (N-DLBCL) during treatment, respectively.

Methods
Total 51 GI-DLBCL patients and 80 N-DLBCL patients were included after retrieving clinical data from a single medical center in the past ten years. Logistic regression analysis was utilized to analyze patients’ data, including baseline demographics, treatments and laboratory values, to determine independent risk factors of infection in these patients.

Results
Total 28 of 51 patients (54.9%) in the GI-DLBCL group and 52 of 80 patients (65%) in the N-DLBCL group were observed infection events during treatment. A multivariate logistic regression model revealed that Ann-arbor stage IV (P = 0.034; odds ratio [OR]: 10.635; 95% confidence interval [CI]: 1.152-142.712), extra-nodal lesions ≥ 2 (P = 0.041; OR: 23.116; 95%CI: 1.144-466.949) and high serum lactate dehydrogenase (LDH) at the time of diagnosis (LDH > 252U/L; P = 0.033; OR: 6.058; 95%CI: 1.159–31.659) were independent risk factors for the development of infection in patients with GI-DLBCL after systemic treatment. In the N-DLBCL group, high serum C-reactive protein (CRP) (P = 0.027; OR: 1.104; 95%CI: 1.011–1.204) and a low platelet count (P = 0.041; OR: 0.991; 95%CI: 0.982-1.000) at routine blood tests just before infection occurred were identified as significant risk factors related to infection events during treatment.

Conclusions
Discordant independent risk factors induced infection may be present during the treatment in patients with GI-DLBCL and N-DLBCL. Close monitoring these risk factors is likely an effective strategy to prevent microbial infections in these patients.
Long-term trends of nasopharyngeal carcinoma mortality in China from 2006 to 2020 by region and sex: an age-period-cohort analysis
Authors: Guo Xinru , Cui Jiameng , Yuan Xin , Gao Zibo , Yu Ge , Wu Hao , Kou Changgui 
Published: October 2023

Abstract
Background
China has a high mortality from nasopharyngeal carcinoma (NPC). The NPC mortality trends in China from 2006 to 2020 were described and analyzed to understand its epidemiological characteristics by region and sex and to explore age, period, and cohort effects.

Methods
This study utilized NPC mortality data from the China Health Statistical Yearbook. A joinpoint regression model was used to fit the standardized NPC mortality and age-specific mortality. The age-period-cohort model was applied to investigate age, period, and cohort effects on NPC mortality risk.

Results
The results showed that the NPC mortality rate in China has been declining steadily. From 2006 to 2020, the standardized NPC mortality rate in most age groups showed a significant downward trend. The annual percentage change was smaller in rural areas than in urban areas. The mortality risks of rural males and rural females from 2016 to 2020 were 1.139 times and 1.080 times those from 2011 to 2015, respectively. Both urban males born in 1984–1988 and rural males born in 1979–1983 exhibited an increasing trend in NPC mortality risk.

Conclusions
Our study confirmed the effectiveness of NPC prevention and treatment strategies in China from 2006 to 2020. However, it underscored the urgent need for targeted interventions in rural areas to further reduce NPC mortality rates.
Using novel porous metal pillars for tibial bone defects in primary total knee arthroplasty
Authors: Tang Qiheng , Guo Shaoyi , Deng Wang , Zhou Yixin 
Published: October 2023

Abstract
Background
The optimal method to treat tibial bone defects during primary total knee arthroplasty (TKA) is still unclear. A novel technique of porous metal pillar augmentation has been applied recently. This study aimed to assess the short-term outcomes of primary TKA with the use of novel porous metal pillars for tibial bone defects.

Methods
A total of 24 cases (22 patients) of primary TKA between January 2019 and December 2020 using porous metal pillars for tibial bone defects were reviewed. Clinical results were evaluated using the Knee Society knee score (KSKS) and function score (KSFS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and range of motion (ROM). Hip-knee-ankle angle (HKAA), femorotibial angle (FTA), and radiolucent lines were assessed radiologically.

Results
The median follow-up period was 36.0 months (interquartile range: 31–37 months). The KSKS, KSFS, WOMAC score, and ROM improved significantly at the final follow-up assessment compared with the preoperative evaluation. Both of the HKAA and FTA were corrected after surgery. Only one knee had a nonprogressive radiolucent line at the bone-cement interface. No radiolucent lines were detected around the pillar in any of the cases. There were no cases of prosthesis loosening and revision.

Conclusions
The use of novel porous metal pillars yielded satisfactory clinical outcomes and reliable radiological evidence of fixation in this study with a minimum 2-year follow-up. Porous metal pillar augmentation can be considered as a valuable and easy-to-use method for the management of tibial bone defects in primary TKA.