bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transdiagnostic phenomena of psychopathology in the context of the RDoC: protocol of a multimodal cross-sectional study
Authors: Meiering Marvin S. , Weigner David , Enge Sören , Grimm Simone 
Published: September 2023

AbstractIn the past, affective and cognitive processes related to psychopathology have been examined within the boundaries of phenotype-based diagnostic labels, which has led to inconsistent findings regarding their underlying operating principles. Investigating these processes dimensionally in healthy individuals and by means of multiple modalities may provide additional insights into the psychological and neuronal mechanisms at their core. The transdiagnostic phenomena Neuroticism and Rumination are known to be closely linked. However, the exact nature of their relationship remains to be elucidated. The same applies to the associations between Hedonic Capacity, Negativity Bias and different Emotion Regulation strategies.This multimodal cross-sectional study examines the relationship of the transdiagnostic phenomena Neuroticism and Rumination as well as Hedonic Capacity, the Negativity Bias and Emotion Regulation from a RDoC (Research Domain Criteria) perspective. A total of 120 currently healthy subjects (past 12 months) will complete several questionnaires regarding personality, emotion regulation, hedonic capacity, and psychopathologies as well as functional magnetic resonance imaging (fMRI) during cognitive and emotional processing, to obtain data on the circuit, behavioral and self-report level.This study aims to contribute to the understanding of the relationship between cognitive and affective processes associated with psychopathologies as well as their neuronal correlates. Ultimately, a grounded understanding of these processes could guide improvement of diagnostic labels and treatments. Limitations include the cross-sectional design and the limited variability in psychopathology scores due to the restriction of the sample to currently healthy subjects.
Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas
Authors: Amani Vladimir , Riemondy Kent A. , Fu Rui , Griesinger Andrea M. , Grimaldo Enrique , De Sousa Graziella Ribeiro , Gilani Ahmed , Hemenway Molly , Foreman Nicholas K. , Donson Andrew M. , Willard Nicholas 
Published: September 2023

AbstractPlexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), often disfiguring or threatening vital structures. During formation of PN, a complex tumor microenvironment (TME) develops, with recruitment of neoplastic and non-neoplastic cell types being critical for growth and progression. Due to the cohesive cellularity of PN, single-cell RNA-sequencing is difficult and may result in a loss of detection of critical cellular subpopulations. To bypass this barrier, we performed single-nuclei RNA-sequencing (snRNA-seq) on 8 frozen PN samples, and integrated this with spatial transcriptomics (ST) in 4 PN samples and immunohistochemistry to provide morphological context to transcriptomic data. SnRNA-seq analysis definitively charted the heterogeneous cellular subpopulations in the PN TME, with the predominant fraction being fibroblast subtypes. PN showed a remarkable amount of inter-sample homogeneity regarding cellular subpopulation proportions despite being resected from a variety of anatomical locations. ST analysis identified distinct cellular subpopulations which were annotated using snRNA-seq data and correlated with histological features. Schwann cell/fibroblast interactions were identified by receptor/ligand interaction analysis demonstrating a high probability of Neurexin 1/Neuroligin 1 (NRXN1/NLGN1) receptor-ligand cross-talk predicted between fibroblasts and non-myelinated Schwann cells (NM-SC) and subtypes, respectively. We observed aberrant expression of NRXN1 and NLGN1 in our PN snRNA-seq data compared to a normal mouse sciatic nerve single-cell RNA-seq dataset. This pathway has never been described in PN and may indicate a clear and direct communication pathway between putative NM-SC cells of origin and surrounding fibroblasts, potentially driving disease progression. SnRNA-seq integrated with spatial transcriptomics advances our understanding of the complex cellular heterogeneity of PN TME and identify potential novel communication pathways that may drive disease progression, a finding that could provide translational therapy options for patients with these devastating tumors of childhood and early adulthood.
A plasma irradiation system optimized for space weathering of solar system bodies
Authors: Kimura Tomoki , Otsuki Misako , Kitano Tomohiro , Hoshino Ryo , Nakauchi Yusuke , Haganuma Shunsuke , Haganuma Ryu , Haganuma Tetsuo , Tsuchiya Fuminori , Tamagawa Toru , Hayato Asami , Kimura Jun , Terada Naoki , Usui Hideyuki , Nishino Masaki N. , Yokota Shoichiro , Miyake Yohei 
Published: September 2023

AbstractIn the tenuous atmospheric bodies of our solar system, space weathering on the celestial surface is an important process for its chemical and physical evolution and ambient environment on timescales of celestial evolution. Space plasma is a dominant energy and material source for space weathering. Plasma irradiation experiment in the laboratory is an effective method for modeling space weathering driven by space plasma. However, comprehensive modeling of plasma space weathering has not yet been conducted because the capabilities of the earlier facilities were not optimized for realistic space weathering; for example, the incident electron and ion were not irradiated in the same condition. Here, we developed a plasma irradiation system, Plasma Irradiation Emulator for Celestial Environments (PIECE) of the solar system bodies, which reproduces plasma space weathering in tenuous atmospheric bodies by the electron and ion irradiations in the same condition. We successfully developed a system with high electron and ion number fluxes of $$\sim 10^{13} - 10^{16} {\text{ particles cm}}^{{ - {2}}} {\text{s}}^{{ - {1}}}$$

∼

10
13

-

10
16

particles cm

-
2

s

-
1

at any acceleration energy in the range of 1–30 keV, which leads to a fluence of e.g., $$\sim 10^{18} - 10^{21} {\text{ particles cm}}^{{ - {2}}} {\text{s}}^{{ - {1}}}$$

∼

10
18

-

10
21

particles cm

-
2

s

-
1

, with a 1-day irradiation time. This fluence corresponds to a plasma irradiation time of ~ 103–106 years on Europa.
Graphical Abstract
A novel minimally invasive and press‐fit method for symphysiodesis — a biomechanical analysis
Authors: Fritz Tobias , Orth Marcel , Hopp Sascha J. , Briem Jeremy , Hahner Jill , Osche David , Pohlemann Tim , Pizanis Antonius 
Published: September 2023

AbstractPurposeDoes the cylindrical shaped bone block allow a stable construct for the arthrodesis of the pubic symphysis compared to a rectangular shaped bone block. The cylindrical shaped bone block stabilized by a 3.5 symphyseal plate is inferior to the stabilization with an internal fixator.MethodsThis study analyzed the arthrodesis of the pubic symphysis on 24 synthetic pelvises, using a rectangular shaped bone block (control group) or a cylindrical shaped bone block, stabilized with a symphysis locking plate (n = 8) as the standard clinical procedure. Additionally we analyzed the stability using an internal fixator.ResultsThis study showed that utilizing a cylindrical shaped synthetic bone graft results in a significant higher contact area and compression force compared to the classical rectangular shaped graft. Furthermore, the stabilization with an internal fixator had the tendency for increases of compression force and contact area, yet without a statistical significance, when compared to the plate fixation.ConclusionThe novel method of cylindrical symphysis resection and cylindrical bone block implantation allowed an increased biomechanical stability compared to using a classical rectangular bone graft, also resulting in higher contact area. Moreover, this technique would also allow a minimally invasive approach for this purpose, which in turn could preserve perisymphyseal ligaments, thereby improving healing in a clinical context.
Can sediments play a role in river flood risk mapping? Learning from selected European examples
Authors: Nones Michael , Guo Yiwei 
Published: September 2023

Abstract
Background
Climate change and increasing anthropogenic pressure are two of the major drivers of increasing extreme events like droughts and floods. To deal with the increasing number of flooding events hitting Europe in the last few decades, around twenty years ago the European Commission started to develop ad-hoc legislation to reduce flood risk by mapping flood hazard and risk areas, such as the Directive 2007/60/EC on the Assessment and Management of Flood Risk. This Directive looks to identify regions where flood management strategies should be prioritized. Despite this holistic approach, flaws connected to the consideration of sediment transport and morphological changes in rivers exist, leading to potential underestimations of the impact of floods affecting active watercourses or areas subjected to frequent morphological changes.

Results
By discussing six examples related to European lowland and mountain watercourses affected by significant floods in the last 20 years, the present mini-review aims to provide additional evidence on the need for a rethinking of flood risk mapping, moving from a “clear water” perspective to a more integrated approach, where the interactions between all the fluvial components (water, sediment, biota, and humans) are adequately considered.

Conclusions
The examples reported here show the importance of considering sediment and wood in flood risk management, suggesting the need for integrating flood-related studies with other disciplines like geomorphology and ecohydrology.
Questionable advisability of vitamin and mineral dietary supplement use in adolescents
Authors: Kotnik Katja Zdešar , Seljak Barbara Koroušić , Gregorič Matej , Jurak Gregor , Golja Petra 
Published: September 2023

Abstract
Objective
Present study aimed to assess potential health risk in Slovenian adolescents due to inadequate diet and/or dietary supplement (DS) use.

Methods
Data on DS use, micronutrient intake (24-h recall), eating habits (FFQ), body height and mass were collected within ACDSi (Analysis of Children’s Development in Slovenia) cross-sectional study conducted in 2014. Adolescents enrolled in first year of 15 secondary schools (average (SD) age: 15.4 (0.7) years, N = 342) were included in the sample.

Results
Adolescents’ use of DS (especially multivitamins ingested as a popular drink (60%), magnesium (16%), and vitamin C (10%)) significantly contributed to their absolute intake of vitamins/minerals, resulting in higher percentage of DS users meeting reference values proposed by the nutrition societies of Germany, Austria, and Switzerland (D-A-CH recommendation). Simultaneously, DS users did not exceed the upper tolerable level proposed by the European Food Safety Authority for daily intake. With diet alone, adolescents consumed less than recommended amounts of the following vitamins/minerals: the intake was lowest for fat-soluble vitamins A, D, and E; water-soluble vitamins folate, biotin, and pantothenic acid; and minerals fluoride, iodine, chromium, and molybdenum. Suboptimal intake was due to the fact that around ¾ of adolescents consumed less than 54% of the recommended amounts (according to Optimized Mixed Diet (OMD) recommendations) for fruits, vegetables, milk/dairy products, fish, and cereals/cereal products. In contrast, the diet contributed to the consumption of 200–300% of D-A-CH minimum value for sodium. Furthermore, almost ¾ of adolescents exceeded the recommended amount for meat/meat products (320% of OMD) and sweet/salty snacks (453% of OMD).

Conclusions
Although DS use improved micronutrient intake in adolescents (especially vitamin C and magnesium), activities on public-health interventions should be focus to improve their diets, especially to achieve increased intakes of fruits, vegetables, cereals/cereal products and milk/dairy products, and to reduce consumption of sweet/salty snacks and meat products.
Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity
Authors: Schneider Karl H. , Oberoi Gunpreet , Unger Ewald , Janjic Klara , Rohringer Sabrina , Heber Stefan , Agis Hermann , Schedle Andreas , Kiss Herbert , Podesser Bruno K. , Windhager Reinhard , Toegel Stefan , Moscato Francesco 
Published: September 2023

AbstractDue to its high printing resolution and ability to print multiple materials simultaneously, inkjet technology has found wide application in medicine. However, the biological safety of 3D-printed objects is not always guaranteed due to residues of uncured resins or support materials and must therefore be verified. The aim of this study was to evaluate the quality of standard assessment methods for determining the quality and properties of polyjet-printed scaffolds in terms of their dimensional accuracy, surface topography, and cytotoxic potential.Standardized 3D-printed samples were produced in two printing orientations (horizontal or vertical). Printing accuracy and surface roughness was assessed by size measurements, VR-5200 3D optical profilometer dimensional analysis, and scanning electron microscopy. Cytotoxicity tests were performed with a representative cell line (L929) in a comparative laboratory study. Individual experiments were performed with primary cells from clinically relevant tissues and with a Toxdent cytotoxicity assay.Dimensional measurements of printed discs indicated high print accuracy and reproducibility. Print accuracy was highest when specimens were printed in horizontal direction. In all cytotoxicity tests, the estimated mean cell viability was well above 70% (p < 0.0001) regardless of material and printing direction, confirming the low cytotoxicity of the final 3D-printed objects.
Graphical Abstract
Prevalence of hopelessness and suicidal ideation and their associated factors among pediatric patients with leukemia
Authors: Zekavat Omid Reza , Safari Negar , Sahraian Ali , Bordbar Mohammadreza , Pakniyat Amirabbas , Bozorgi Haleh 
Published: September 2023

Abstract
Background
With the increasing survival rate of pediatric patients with leukemia, improving their quality of life (QoL) is the new challenge. Psychiatric disorders are among the significant confounding factors of the aforementioned patients’ QoL. Ninety-seven pediatric patients with leukemia were evaluated based on the Beck Hopelessness and SI scale while considering associated factors. We assessed the prevalence of suicidal ideation (SI) and hopelessness, as two of the most prevalent psychiatric symptoms of pediatrics with malignancy while assessing some of the associated factors to provide a plenary insight.

Results
Prevalence of SI and hopelessness were 7.2% and 87.6% respectively. Gender, education, the abode of living, time from onset of disease, and parents’ education level and income states of many were significantly related to the prevalence of the two studied psychiatric disorders. Multiple logistic regression determined a significant confounding role of abode of living, parent’s education, onset, and type of leukemia in hopelessness. As for SI, the result of the latter test determined more confounding factors such as age and patients’ education.

Conclusion
Both SI and hopelessness are noticeable disorders among children with leukemia with multiple manageable associated factors; hence, it is advisable to recommend psychiatric assessment of leukemic children.
Stress responses of plants through transcriptome plasticity by mRNA alternative polyadenylation
Authors: Zhou Jiawen , Li Qingshun Quinn 
Published: September 2023

AbstractThe sessile nature of plants confines their responsiveness to changing environmental conditions. Gene expression regulation becomes a paramount mechanism for plants to adjust their physiological and morphological behaviors. Alternative polyadenylation (APA) is known for its capacity to augment transcriptome diversity and plasticity, thereby furnishing an additional set of tools for modulating gene expression. APA has also been demonstrated to exhibit intimate associations with plant stress responses. In this study, we review APA dynamic features and consequences in plants subjected to both biotic and abiotic stresses. These stresses include adverse environmental stresses, and pathogenic attacks, such as cadmium toxicity, high salt, hypoxia, oxidative stress, cold, heat shock, along with bacterial, fungal, and viral infections. We analyzed the overarching research framework employed to elucidate plant APA response and the alignment of polyadenylation site transitions with the modulation of gene expression levels within the ambit of each stress condition. We also proposed a general APA model where transacting factors, including poly(A) factors, epigenetic regulators, RNA m6A modification factors, and phase separation proteins, assume pivotal roles in APA related transcriptome plasticity during stress response in plants.
Graphical Abstract
Lessons for Losing
Authors: Pratt Mary Louise 
Published: September 2023

Abstract
This essay examines how two very different thinkers address the question of how to live loss. The first is the Canadian Cree artist and writer Tomson Highway, author most recently of Laughing with the Trickster: On Sex, Death, and Accordians, and the second is US environmental writer Elizabeth Rush, author of Rising: Dispatches from the New American Shore. In two very different modalities of knowledge making, we see a shared quest for a planetary subject able to live loss in a clear-eyed and affirmative way. For Highway, the question is how to live loss, beginning with language loss, without losing the capacity for laughter and joyfulness. The arts of the trickster are his answer. For Rush, the question is: what changes can we be making now to head off crisis, and what language can make such change meaningful and desirable? We also see the two writers striving to make language respond to the challenge of scale. How do you capture the gigantic without being abstract? Highway moves to the mythic, arguing for Indigenous pantheism. Rush tacks between the particulars of planet science and the personal narratives of those living the loss of place.
“That Great Mother of Danger”
Authors: Anidjar Gil 
Published: September 2023

Abstract
Were one to trust the experts of “the risk society,” and the countless volumes that take risk as their object, one might conclude that we have lost sight of danger. How secure is the distinction? This essay registers the discursive proliferation that has surrounded risk, as opposed to the poverty of theorizations of danger. Since Mary Douglas's famous 1966 contribution, it is as if the two terms were synonymous. Yet linguistic usage, along with other counterexamples, signal that we might learn from attending to danger in its specificity. The essay then turns to Sigmund Freud, that little-recognized thinker of danger. It was Freud who located loss—and the mother—at the center of what he strikingly called the “danger-situation.”
Alterable Geographies
Authors: Winchell Mareike 
Published: September 2023

Abstract
Like plantation slavery, Indigenous servitude on Bolivian haciendas raises crucial questions about the afterlives of colonial subjection. Engaging questions of colonialism, unfreedom, and emancipation across the Americas, this article examines how Quechua Bolivians remake landscapes defined by continued material traces of subjection and abiding racial inequalities. Rather than inhabiting this landscape as one of passive historical repetition, Quechua Bolivians use narratives and spatial practices to alter landscapes—including elderberry trees where kin were whipped, high mountain lakes constructed by forced laboring kin, and ravines and valley crevices that offered routes of escape from indentured labor and political violence. Such practices point to a politics of lo abigarrado (the motley), a term used to describe people whose labor itineraries and affective attachments have not been constrained by the frames of Mestizo citizenship and timeless Indigenous rootedness to place. Through this spatial poetics, Quechua families thwart nationalist paradigms of propertied redress to forge alternate plotlines of emancipation based on keeping time, and places, open to the demands of a violent past.
Manic History
Authors: Bracken Christopher 
Published: September 2023

AbstractOn May 27, 2021, the Tk'emlúps te Secwépemc First Nation reported the discovery of 215 unmarked graves on the site of the former Kamloops Indian Residential School in British Columbia. Their first response was mourning for the loss of young lives; their second response was melancholia for the loss of the children's names. David Eng and David Kazanjian advocate a “counterintuitive” interpretation of melancholia as “creative,” redefining it as the work of mourning that sustains “a continued and open relation to the past.” Jeff Barnaby's 2013 film about residential school resistance, Rhymes for Young Ghouls, affirms melancholia as a creative relation to the past for Indigenous people while drawing attention to another agency that allows settler society to actively lose the past. Freud remarks that the “most remarkable” quality of melancholia is the way it turns into mania, which ensues when “the ego coincides with the ego ideal.” What if some losses do not make us melancholic but manic? Is it possible to make history by losing history? Settler mania incites Indigenous melancholia by displacing responsibility for children's deaths from church and state to parents who are themselves school survivors.
Losing Salvation
Authors: Armstrong Amaryah Shaye 
Published: September 2023

Abstract
This essay argues that critiques of redemption in contemporary black theory necessitate a rethinking of black theology in terms of loss so as to upend the political theological order of redemption and damnation that justifies antiblack governance of thought and existence. Through an immanent reading of political theology's appearance in ostensibly secular black feminist thought, the article shows how these wayward metabolizations of black theology's internal and external contradictions—specifically, those that illuminate a fundamental crisis of meaning at its heart—reveal black theology's abjection and alienation from its own stated desires for redemption. The article argues that this debasement of black theology opens onto its significance for black thought. As a form of black thought, black theology and its ongoing crisis of meaning crystallize the political theological crisis of illegitimacy and alienation generated by the failed announcement of redemption in racial slavery's wake. Through a reading of Saidiya Hartman and Christina Sharpe's work, the article shows how a wayward form of black theology is immanent in the ostensibly secular work of these and other radical black theorists. Taking their critiques of the redemptive theology that undergirds antiblackness as instructive, the article argues that a wayward, rather than confessional, form of black theology is already operative in realms of black studies that might be called nontheological. Recasting black political and theological desire for the coherence of redemption as a failure, the article proposes a loss of salvation and heretical appropriation of Christian theological materials as a demand for black thought. By critically reoccupying the sense of damnation that marks blackness, radical black reproductions of theological knowledge can insist on a disinherited procedure of thought—a rebellious gnosis in blackness—that disfigures the romance of redemption.