bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of difficulties with emotion regulation on the longitudinal relationship between peer victimization and changes in adolescent nonsuicidal self‐injury
Authors: Li Jinwen , Gao Yemiao , Liu Jinmeng , Liu Xia , Wang Hui 
Published: November 2023

AbstractIntroductionResearch has found that peer victimization is associated with adolescent nonsuicidal self‐injury (NSSI) behavior; however, most of these studies ignored the association between these constructs at the within‐person level. Additionally, the association between peer victimization and NSSI may vary among adolescents with different personal characteristics. With a longitudinal design, this study investigated whether and how emotion regulation (ER) difficulties moderate the relationship between peer victimization and changes in NSSI, with particular attention given to the unique moderating role of different dimensions of ER difficulties.MethodsThe study sample comprised 3,561 adolescents aged between 10 and 17 years old (Mage = 13.22, SD = 0.85; 56.9% males). Self‐report assessments were administered in December 2021 and June 2022 in Shanxi province, China.ResultsThe latent change score model showed that the adolescent NSSI increased during our assessments, with peer victimization as a significant predictor. ER difficulties moderated the association between peer victimization and NSSI changes, but interestingly, in an unexpected pattern. Specifically, peer victimization significantly predicted NSSI changes among adolescents with low ER difficulties but not for those with high ER difficulties. Moreover, among the multiple dimensions of ER difficulties, only nonacceptance of emotional responses and limited access to emotion regulation strategies interacted with peer victimization to predict NSSI changes and showed interaction patterns similar to those at the overall level of ER difficulties.ConclusionsThe current study revealed the moderating role of ER difficulties in the relationship between peer victimization and changes in NSSI. These findings provide intervention implications for adolescents who engage in NSSI.
Near‐infrared light does not induce DNA damage in human dermal fibroblasts
Authors: Mineroff Jessica , Wang Jennifer Y. , Philip Raichel , Austin Evan , Jagdeo Jared 
Published: November 2023

AbstractPhotobiomodulation (PBM) can be used to treat a range of conditions in dermatology. PBM refers to the changes induced by red (RL, 620–700 nm) and near‐infrared (NIR, 700–1440 nm) light. Light radiation‐induced DNA damage is a major contributor to aging and skin cancer. It is crucial to study the effects of PBM on DNA to ensure safety. Our lab previously demonstrated that RL (633 ± 6 nm) did not result in human dermal fibroblasts (HDFs) DNA damage. This study employed similar methods to investigate NIR effects. Commercially available LED‐NIR (830 ± 5 nm) panels (66, 132, and 264 J/cm2) did not result in DNA damage measured by cyclobutane pyrimidine dimers and pyrimidine‐6,4‐pyrimidone photoproducts in HDFs compared to temperature‐matched controls immediately, 3 h, and 24 h following irradiation and compared to positive and negative controls. This demonstrates that LED‐NIR does not damage DNA in HDFs in vitro.
Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells
Authors: Goodarzi Kasra , Lane Rachel , Rao Shreyas S. 
Published: November 2023

AbstractA majority of breast cancer deaths occur due to metastasis of cancer cells to distant organs. In particular, brain metastasis is very aggressive with an extremely low survival rate. Breast cancer cells that metastasize to the brain can enter a state of dormancy, which allows them to evade death. The brain microenvironment provides biophysical, biochemical, and cellular cues, and plays an important role in determining the fate of dormant cancer cells. However, how these cues influence dormancy remains poorly understood. Herein, we employed hyaluronic acid (HA) hydrogels with a stiffness of ~0.4 kPa as an in vitro biomimetic platform to investigate the impact of biochemical cues, specifically alterations in RGD concentration, on dormancy versus proliferation in MDA‐MB‐231Br brain metastatic breast cancer cells. We applied varying concentrations of RGD peptide (0, 1, 2, or 4 mg/mL) to HA hydrogel surfaces and confirmed varying degrees of surface functionalization using a fluorescently labeled RGD peptide. Post functionalization, ~10,000 MDA‐MB‐231Br cells were seeded on top of the hydrogels and cultured for 5 days. We found that an increase in RGD concentration led to changes in cell morphology, with cells transitioning from a rounded to spindle‐like morphology as well as an increase in cell spreading area. Also, an increase in RGD concentration resulted in an increase in cell proliferation. Cellular dormancy was assessed using the ratio of phosphorylated extracellular signal‐regulated kinase 1/2 (p‐ERK) to phosphorylated p38 (p‐p38) positivity, which was significantly lower in hydrogels without RGD and in hydrogels with lowest RGD concentration compared to hydrogels functionalized with higher RGD concentration. We also demonstrated that the HA hydrogel‐induced cellular dormancy was reversible. Finally, we demonstrated the involvement of β1 integrin in mediating cell phenotype in our hydrogel platform. Overall, our results provide insight into the role of biochemical cues in regulating dormancy versus proliferation in brain metastatic breast cancer cells.
Dual Z‐scheme ternary heterojunction photocatalyst with enhanced visible‐light photocatalytic degradation of organic pollutants
Authors: Wu Fangzhou , Liu Ying , Chen Xiyu , Han Jun , Hu De , Wang Wei , Wang Shufen 
Published: November 2023

AbstractPhotocatalysis technology driven by solar energy is considered to be promising for solving energy crisis and environmental problems. Graphitic carbon nitride has been widely researched in the photocatalysis field due to its suitable band positions, non‐toxicity, easy synthesis, high stability, and low cost. However, the slow separation and rapid recombination of photogenerated carriers, the poor visible light response and the low specific surface area seriously limit the photocatalytic activity of g‐C3N4. Here, firstly, g‐C3N4 nanosheets with a large specific surface area of 152.2 m2 g−1 which provide more surface‐active sites for photocatalysis were prepared by secondary calcination method. Next, MoS2 and metal–organic framework (MIL‐101(Cr)) were tightly bonded on g‐C3N4 nanosheets to form ternary g‐C3N4/MoS2/MIL‐101(Cr) heterojunction photocatalyst. In which, a ternary dual Z‐scheme heterojunction photocatalyst composed of g‐C3N4, MoS2, and MIL‐101(Cr) was constructed to facilitate the separation and the migration of photogenerated charges. At the same time, MoS2 enhanced the visible light response of the ternary photocatalyst. The optimal ternary photocatalyst displayed the highest activity for methyl orange degradation (degradation efficiency of 98% in 60 min) under visible light irradiation. Finally, a photocatalytic mechanism of a dual Z‐scheme electron transfer channel and h+‐·O2− double oxidation sites were proposed and discussed.
Monitoring by Raman spectroscopy of rabies virus‐like particles production since the initial development stages
Authors: Guardalini Luis Giovani Oliveira , Rangel Rafaela Morais , Leme Jaci , Bernardino Thaissa Consoni , Silveira Suellen Regina da , Tonso Aldo , Jorge Soraia Attie Calil , Núñez Eutimio Gustavo Fernández 
Published: November 2023

AbstractBACKGROUNDThis study aimed to establish chemometric models using Raman spectroscopy data for biochemical monitoring of rabies Virus‐Like Particles (VLP) production based on baculovirus/insect cell system. The models were developed using fresh and stored samples from the initial development stages (Schott culture flasks). The following modeling techniques were assessed: partial least squares (PLS) and artificial neural networks (ANN). The effects of spectral filtering approaches, spectral ranges (400–1850 cm−1; 100–3425 cm−1), and sample cryopreservation were also considered. The applicability of the models was evaluated using experimental data from assays carried out in a benchtop bioreactor.RESULTSThe results showed that the prediction capacity of the chemometric models was negatively impacted when samples from rabies VLP production were cryopreserved. Further studies are needed to confirm the maximum storage time for samples (< 4 months) without a significant difference in model predictions compared to those from an in line database. The dilution of the sample should be kept constant throughout the rabies VLP development stages. A nonlinear correlation was observed between dilution and the predicted values of biochemical parameters from Raman spectral data. The choice of spectral filtering has a major impact on the prediction accuracy of chemometric models.CONCLUSIONThe optimal filtering approach should be individually optimized for each biochemical parameter. The ANN models were significantly more suitable for biochemical monitoring than the PLS approach. The 400–1850 cm−1 Raman shift range is recommended for biochemical monitoring of rabies VLP using a baculovirus/insect cell platform when samples are cell‐free. © 2023 Society of Chemical Industry (SCI).
Transcranial Doppler ultrasound velocities in a population of unstudied African children with sickle cell anemia
Authors: O'Brien Nicole F. , Moons Peter , Johnson Hunter , Tshimanga Taty , Musungufu Davin Ambitapio , Ekandji Robert Tandjeka , Mbaka Jean Pongo , Babatila Lydia Kuseyila , Mayindombe Ludovic , Giresse Buba , Mwanza Suzanna , Lupumpaula Clement , Chilima Janet Simanguwa , Nanyangwe Alice , Kabemba Peter , Kafula Lisa Nkole , Phiri Tusekile , June Sylvester , Gushu Montfort Bernard , Chagaluka George , Chunda‐Liyoka Catherine M. 
Published: November 2023

AbstractThe greatest burden of sickle cell anemia (SCA) globally occurs in sub‐Saharan Africa, where significant morbidity and mortality occur secondary to SCA‐induced vasculopathy and stroke. Transcranial Doppler ultrasound (TCD) can grade the severity of vasculopathy, with disease modifying therapy resulting in stroke reduction in high‐risk children. However, TCD utilization for vasculopathy detection in African children with SCA remains understudied. The objective was to perform a prospective, observational study of TCD findings in a cohort of children with SCA from the Democratic Republic of the Congo, Zambia, and Malawi. A total of 770 children aged 2–17 years without prior stroke underwent screening TCD. A study was scored as low risk when the time‐averaged maximum of the mean (TAMMX) in the middle cerebral artery or terminal internal carotid artery was <170 cm/s but >50 cm/s, conditional risk when 170–200 cm/s, and high risk when >200 cm/s. Low‐risk studies were identified in 604 children (78%), conditional risk in 129 children (17%), and high risk in three children (0.4%). Additionally, 34 (4%) were scored as having an unknown risk study (TAMMX <50 cm/s). Over the course of 15 months of follow‐up, 17 children (2.2%) developed new neurologic symptoms (six with low‐risk studies, seven with conditional risk, and four with unknown risk). African children with SCA in this cohort had a low rate of high‐risk TCD screening results, even in those who developed new neurologic symptoms. Stroke in this population may be multifactorial with vasculopathy representing only one determinant. The development of a sensitive stroke prediction bundle incorporating relevant elements may help to guide preventative therapies in high‐risk children.
Comparison of unilateral and bilateral intraductal plastic stent placement for unresectable malignant hilar biliary obstruction: A propensity score‐matched cohort analysis
Authors: Okuno Mitsuru , Iwata Keisuke , Mukai Tsuyoshi , Iwasa Yuhei , Uemura Shinya , Yoshida Kensaku , Maruta Akinori , Iwashita Takuji , Yasuda Ichiro , Shimizu Masahito 
Published: November 2023

AbstractBackgroundAlthough intraductal plastic stent (IS) placement is an effective treatment for unresectable malignant hilar biliary obstruction (UMHBO), the effectiveness of unilateral and bilateral IS drainage remains controversial. This retrospective study investigated the effectiveness of bilateral IS placement for UMHBO using the propensity score matching method.MethodsPatients who underwent transpapillary endoscopic stenting for UMHBO were analyzed for technical and clinical success, adverse events, and time to recurrent biliary obstruction (TRBO).ResultsA total of 321 patients were enrolled in the study with 27 patients in each unilateral and bilateral IS group in the propensity score‐based cohort. Technical success was 100%, while clinical success was 93% and 96% in the unilateral and bilateral IS groups, respectively (p = 1.0). Cholecystitis occurred in 4% and 7%, respectively (p = 1.0). The median TRBO was shorter in the unilateral group (129 [5–383] days) than that in the bilateral group (226 [16–563] days) (p = .0281). Bilateral IS placement was an independent long TRBO factor (hazard ratio [HR] 0.46; 95% confidence interval [CI]: 0.21–0.97; p = .041).ConclusionsUnilateral and bilateral IS placement had high technical and clinical success rates in primary stent placement. However, bilateral IS placement showed a longer TRBO. Bilateral IS placement may be a good option for initial UMHBO drainage.
Unlike chemical fertilizer reduction, organic fertilizer substitution increases soil organic carbon stock and soil fertility in wheat fields
Authors: He Hao , Peng Mengwen , Hou Zhenan , Li Junhua 
Published: November 2023

AbstractBACKGROUNDImprovements in farmland soil organic carbon (SOC) stock enhance crop yield and soil fertility while mitigating climate change. Rational fertilization in agricultural production is crucial for safeguarding SOC stock. In this study, field experiments were conducted with different ratios of chemical fertilizer reduction and organic fertilizer substitution for three consecutive years (2018–2020) to explore their effects and interlinkages on SOC fractions, soil properties and SOC stock.RESULTSThe results showed that organic fertilizer substitution increased SOC and its fractions content, SOC stock (by 3.98–12.98% and 7.15–18.13%) and soil fertility index (by 11.76–49.26% and 33.33–91.47%) compared to conventional fertilization in 2019 and 2020, while chemical fertilizer reduction had the opposite effect. Moreover, soil properties (except total nitrogen to total phosphorus ratio, N/P) and SOC fractions significantly affected SOC stock, with SOC fractions contributing more than soil properties. The high sensitivity of microbial biomass carbon (MBC) and dissolved organic carbon (DOC) can indicate changes in soil carbon pool. Structural equation modeling (SEM) revealed that organic fertilizer substitution increased SOC content and stock by increasing SOC fractions [recalcitrant organic carbon (ROC) and labile organic carbon (LOC) fractions] content and soil fertility.CONCLUSIONSOur study revealed the corresponding mechanisms of the two fertilization modes affecting SOC stock changes. The use of organic fertilizer substitution is recommended to increase SOC stocks and soil fertility in wheat fields. © 2023 Society of Chemical Industry.
Deciphering the underlying core microorganisms and the marker compounds of Liupao tea during the pile‐fermentation process
Authors: Pan Jincen , Wang Jie , Teng Jianwen , Huang Li , Wei Baoyao , Xia Ning , Zhu Pingchuan 
Published: November 2023

AbstractBACKGROUNDPile fermentation is one of the key steps in developing the Liupao tea (LBT) quality and unique characteristics. The complex biochemical profile of LBT results from microorganisms present during the pile‐fermentation process. However, the critical underlying microorganisms and the marker compounds still need to be determined.RESULTSStaphylococcus, Brevibacterium, Kocuria, Aspergillus, and Blastobotrys were the common dominant microorganisms at the end of the pile fermentation of LBT. Staphylococcus, Aspergillus, Blastobotrys, and nine other genera carried by raw tea are the core microorganisms in the LBT during pile fermentation. A total of 29 critical compounds contributed to the metabolic changes caused by the processing of LBT. Of these, gallic acid, adenine, hypoxanthine, uridine, betaine, 3,4‐dihydroxybenzaldehyde, and α‐linolenic acid could be characterized as potential marker compounds. Correlation analysis showed that the core microorganisms, including Sphingomonas, Staphylococcus, Kocuria, Aureobasidium, Blastobotrys, Debaryomyce, and Trichomonascus, were closely related to major chemical components and differential compounds. Moreover, the mutually promoting Staphylococcus, Kocuria, Blastobotrys, and Trichomonascus were correlated with the enrichment of marker compounds. Integrated molecular networking and metabolic pathways revealed relevant compounds and enzymes that possibly affect the enrichment of marker compounds.CONCLUSIONThis study analyzed the LBT fermentation samples by omics analysis to reveal the stable microbial community structure, critical microorganisms, and markers compounds affecting the quality of LBT, which contributes to a better understanding of pile fermentation of LBT and the fermentation theory of dark tea. © 2023 Society of Chemical Industry.
Inhibition of bleomycin‐induced pulmonary fibrosis in SD rats by sea cucumber peptides
Authors: Wu Jianfu , Chen Yijun , Zhang Jinxuan , Cheng Jinghuan , Chen Yongde , Wu Tao , Zhang Min 
Published: November 2023

AbstractBACKGROUNDPulmonary fibrosis (PF) is the terminal manifestation of a type of pulmonary disease, which seriously affects the respiratory function of the body, and with no effective cure for treatment. This study evaluated the effect of sea cucumber peptides (SCP) on bleomycin‐induced SD rat PF.RESULTSSCP can inhibit the PF induced by bleomycin. PF and SCP did not affect the food intake of rats, but PF reduced the body weight of rats, and SCP could improve the weight loss. SCP reduced lung index in PF rats in a dose‐dependent manner. SCP significantly reduced IL‐1β, IL‐6, TNF‐α, α‐SMA and VIM expression levels in lung tissue (P < 0.05), significantly decreased TGF‐β1 expression level in serum (P < 0.01) and the LSCP group and MSCP group had better inhibitory effects on PF than the HSCP group. Histomorphological results showed that SCP could ameliorate the structural damage of lung tissue, alveolar wall rupture, inflammatory cell infiltration, fibroblast proliferation and deposition of intercellular matrix and collagen fibers caused by PF. The improvement effect of the MSCP group was the most noteworthy in histomorphology. Metabolomics results showed that SCP significantly downregulated catechol, N‐acetyl‐l‐histidine, acetylcarnitine, stearoylcarnitine, d‐mannose, l‐threonine, l‐alanine, glycine, 3‐guanidinopropionic acid, prostaglandin D2 and embelic acid d‐(−)‐β‐hydroxybutyric acid expression levels in lung tissue.CONCLUSIONSCP ameliorate bleomycin‐induced SD rat PF. KEGG pathway analysis proved that SCP intervened in PF mainly via the lysosome pathway, with d‐mannose as the key factor. © 2023 Society of Chemical Industry.
Natural antioxidants enhance the oxidation stability of blended oils enriched in unsaturated fatty acids
Authors: Wang Guangyi , Liu Lele , Peng Fuliang , Ma Yuchen , Deng Zeyuan , Li Hongyan 
Published: November 2023

AbstractBACKGROUNDRancidity causes unpleasant tastes and smells, and the degradation of fatty acids and natural antioxidants, so that an oil is unfit to be consumed. Natural antioxidants, including tocopherols, polyphenols (sesamol, canolol, ferulic acid, caffeic acid, etc.), β‐carotene, squalene and phytosterols, contribute to delay the oxidation of vegetable oils. However, studies on the combination of natural antioxidants to lengthen the shelf life of unsaturated fatty acid‐rich blended oil have not been reported.RESULTSAll of the composite antioxidants had the potential to significantly improve the oxidation stability of blended oil. Blended oil G with 0.05 g kg−1 β‐carotene, 0.25 g kg−1 sesamol and 0.25 g kg−1 caffeic acid showed the best anti‐autooxidation. It is also effective in improving the oxidative stability of vegetable oils containing various fatty acids. The oxidation stability index of the blended oil containing the optimum composition of natural antioxidants was 2.17‐fold longer than that of the control sample. After the end of accelerated oxidation, the oil's peroxide value, p‐anisidine value and total oxidation value were 6.59 times, 12.26 times and 6.65 times lower than those of the control sample, respectively.CONCLUSION(1) The combination of natural antioxidants β‐carotene (0.05 g kg−1), sesamol (0.25 g kg−1) and caffeic acid (0.25 g kg−1) enhances the oxidative stability of unsaturated fatty acid‐rich blended oils. (2) β‐Carotene is the main antioxidant in the early stages of oxidation. (3) Sesamol and caffeic acid are the main antioxidants in the middle and late stages of oxidation. © 2023 Society of Chemical Industry.
Effect of surfactants on the interfacial viscoelasticity and stability of silk fibroin at different oil–water interfaces
Authors: Qiao Xiuying , Miller Reinhard , Schneck Emanuel , Sun Kang 
Published: November 2023

AbstractBACKGROUNDThe biocompatible amphiphilic silk fibroin, extracted from domesticated silkworms, can adsorb at the oil–water interface and form elastic interfacial layers. In this study, three surfactants (cationic cetyltrimethylammonium bromide, the nonionic polyoxyethylene sorbitan monolaurate, and the anionic sodium dodecyl sulfate) were selected to investigate, through interfacial shear rheology, the influences of surfactants on the interfacial viscoelasticity and stability of silk fibroin at the interfaces between water and two different oils.RESULTSThe presence of surfactant prolongs the equilibration time and enhances the interfacial elastic modulus and toughness of the interfacial silk fibroin layers, especially at the nonpolar dodecane–water interface. However, when the surfactant exceeds a critical concentration, the shear modulus and stability of interfacial silk fibroin layers begin to decrease due to the competitive adsorption of surfactant molecules and the weakening of the protein network. Owing to electrostatic interactions, the ionic surfactants cetyltrimethylammonium bromide and sodium dodecyl sulfate can form more hydrophobic complexes with silk fibroin, which results in higher shear moduli than for silk fibroin and silk fibroin–polyoxyethylene sorbitan monolaurate mixture.CONCLUSIONBoth the surfactant type and oil polarity play important roles in the adsorption, shear viscoelasticity, and stability of silk fibroin at the oil–water interface. Enhanced interactions between a silk fibroin–surfactant mixture and the oil phase delay the equilibration of the adsorption layers but strengthen the stability of interfacial layers. © 2023 Society of Chemical Industry.