bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enzymatic Synthesis of Indole‐Based Imidazopyridine using α‐Amylase
Authors: Kamboj Priya , Tyagi Vikas 
Published: January 2024

AbstractThe imidazo[1,2‐a]pyridine scaffold has gained significant attention due to its presence as a lead structure in several commercially available pharmaceuticals like zolimidine, zolpidem, olprinone, soraprazan, etc. Further, indole‐based imidazo[1,2‐a]pyridine derivatives have been found interesting due to their anticancer and antibacterial activities. However, limited methods have been reported for the synthesis of indole‐based imidazo[1,2‐a]pyridines. In this study, we have successfully developed a biocatalytic process for synthesizing indole‐based imidazo[1,2‐a]pyridine derivatives using the α‐amylase enzyme catalyzed Groebke‐Blackburn‐Bienayme (GBB) multicomponent reaction of 2‐aminopyridine, indole‐3‐carboxaldehyde, and isocyanide. The generality and robustness of this protocol were shown by synthesizing differently substituted indole‐based imidazo[1,2‐a]pyridines in good isolated yields. Furthermore, to make α‐amylase a reusable catalyst for GBB multicomponent reaction, it was immobilized onto magnetic metal‐organic framework (MOF) materials [Fe3O4@MIL‐100(Fe)] and found reusable up to four consecutive catalytic cycles without the significant loss in catalytic activity.
Intelligent Nano‐Colloidal Electrolytes for Stabilizing Lithium Metal Anodes: A Review
Authors: Lim Minhong , Seo Jiyeon , Choi Bokyung , Kim Beomjun , Lee Jiwon , Park Sanghyun , Lee Hongkyung 
Published: January 2024

AbstractAlthough Li‐metal has been revisited as the most attractive anode in building high‐energy‐density batteries owing to its superiority, such as ultimate theoretical capacity and lowest working voltage, notorious Li dendrite growth has plagued its practical uses. Since dendritic Li electroplating is mostly caused by poor Li+ transport and inferior stability of solid‐electrolyte interphase (SEI), an innovative reframing of the electrolyte is crucial to the success of Li‐metal anodes (LMAs). This review presents a new class of electrolytes, nano‐colloidal electrolytes (NCEs), providing a new avenue for next‐generation Li‐metal batteries (LMBs). Without searching for new salts/solvents or their compositional tuning, NCEs exploiting multi‐functional nanoparticles dispersed in liquid electrolytes can promote Li+ transport and reinforce the SEI of liquid electrolytes that are solely used. This review discusses various types of nanoparticles and their key roles in demonstrating excellent suppression of Li dendrite growth and enhancing the cycling stability of LMBs. Unraveling the underlying design principles of NCEs offers practical solutions for stabilizing LMAs, paving the way for developing intelligent battery systems.
C−C Coupling in CO2 Electroreduction on Single Cu‐Modified Covalent Triazine Frameworks: A Static and Dynamic Density Functional Theory Study
Authors: Ohashi Keitaro , Nagita Kaito , Yamamoto Hiroki , Nakanishi Shuji , Kamiya Kazuhide 
Published: January 2024

AbstractThe electrochemical reduction of CO2 into C2+ products represents a promising solution to completing the carbon cycle, thereby fostering a sustainable energy supply. Single‐atom electrocatalysts (SAECs) have garnered significant attention as efficient electrocatalysts for the CO2 reduction reaction. Herein, we carried out a first‐principles study on the mechanism of C−C bond formation on single‐Cu‐atom‐modified covalent triazine frameworks (Cu‐CTFs), which are a promising platform for SAECs. Static density functional calculations indicated that the dimerization of CO, which is the main mechanism for C−C bond formation on bulk Cu metals, was not favorable for Cu‐CTFs because of the lack of adjacent Cu sites for co‐adsorption of CO molecules. Rather than CO dimerization, the reaction between adsorbed *CHO and CO to produce *COCHO has a relatively low reaction energy barrier. Constrained ab initio molecular dynamics analyses revealed that the C−C bond‐forming reaction proceeds via insertion of CO at the *CHO intermediate, which has a modest activation energy of 0.09 eV. Specifically, when CO molecule is constrained to be brought close to *CHO, CO insertion between *CHO and Cu occurs at a C−C distance of 1.8 Å. This insertion reaction is the transition step for this C−C bond formation.
Synthesis of Superelastic, Highly Conductive Graphene Aerogel/Liquid Metal Foam and its Piezoresistive Application
Authors: Ma Jinlong , Yan Rui , Wo Xiaoye , Cao Yanpeng , Yu Xiao , Li Aijun , Huang Jian , Li Fenghua , Luo Liqiang , Zhang Qixian 
Published: January 2024

AbstractGraphene aerogel (GA) has important application potential as piezoresistive sensors due to its low density, high conductivity, high porosity, and good mechanical properties. However, the fabrication of GA‐based sensors with good mechanical properties and excellent sensing performance is still challenging. Herein, liquid‐ metal‐modified GAs (GA/LM) are proposed for the development of an excellent GA‐based sensor. GA/LM with three‐dimensional interconnected layered structure exhibits excellent compressive stress of 41 KPa and fast response time (<20 ms). While generally flexible GA composites cannot be compressed beyond 80 % strain without plastic deformation, GA/LM demonstrates a high compressive strength of 60 kPa under a strain of 90 %. A real‐time pressure sensor was fabricated based on GA/LM‐2 to monitor swallowing, pulse beating, finger, wrist and knee bending, and even plantar pressure during walking. These excellent features enable potential applications in health detection.
Age at diagnosis and social risks among Black cancer survivors: Results from the Detroit Research on Cancer Survivors cohort
Authors: Hastert Theresa A. , McDougall Jean A. , Robinson Jamaica R. M. , Palakshappa Deepak , Seaton Randell , Ruterbusch Julie J. , Beebe‐Dimmer Jennifer L. , Schwartz Ann G. 
Published: January 2024

AbstractBackgroundSocial risks are common among cancer survivors who have the fewest financial resources; however, little is known about how prevalence differs by age at diagnosis, despite younger survivors’ relatively low incomes and wealth.MethodsThe authors used data from 3703 participants in the Detroit Research on Cancer Survivors (ROCS) cohort of Black cancer survivors. Participants self‐reported several forms of social risks, including food insecurity, housing instability, utility shut‐offs, not getting care because of cost or lack of transportation, and feeling unsafe in their home neighborhood. Modified Poisson models were used to estimate prevalence ratios and 95% confidence intervals (CIs) of social risks by age at diagnosis, controlling for demographic, socioeconomic, and cancer‐related factors.ResultsOverall, 35% of participants reported at least one social risk, and 17% reported two or more risks. Social risk prevalence was highest among young adults aged 20–39 years (47%) followed by those aged 40–54 years (43%), 55–64 years (38%), and 65 years and older (24%; p for trend < .001). Compared with survivors who were aged 65 years and older at diagnosis, adjusted prevalence ratios for any social risk were 1.75 (95% CI, 1.42–2.16) for survivors aged 20–39 years, 1.76 (95% CI, 1.52–2.03) for survivors aged 40–54 years, and 1.41 (95% CI, 1.23–1.60) for survivors aged 55‐64 years at diagnosis. Similar associations were observed for individual social risks and experiencing two or more risks.ConclusionsIn this population of Black cancer survivors, social risks were inversely associated with age at diagnosis. Diagnosis in young adulthood and middle age should be considered a risk factor for social risks and should be prioritized in work to reduce the financial effects of cancer on financially vulnerable cancer survivors.
CNT Sheets Co‐Loaded with Sulfur and Silicon Oxides: Free Standing Anodes for Lithium and Sodium‐Ion Batteries
Authors: Joshi Akhilesh C. , Dutta Dimple P. , Alexander Rajath , Roy Mainak , Dasgupta Kinshuk 
Published: January 2024

AbstractSulfur and silicon oxides loaded self‐supporting binder and collector free CNT sheets have been synthesized using floating catalyst chemical vapor deposition technique and investigated for their application as anodes in lithium/sodium ion battery. The CNT sheets have been characterized thoroughly using various microscopic and spectroscopic techniques. The addition of sulfur improves the interplanar spacing in the lattice and also generated abundant defects. The silicon oxides help in enhancing the specific capacity of the CNT sheet via conversion reactions. These features lead to enhanced electrochemical properties and the best performance has been demonstrated by the co‐loaded CNT/S/silicon oxide electrode. As anode in LIB, it delivers 830 mAh g−1 at 1 A g−1 current density after 250 cycles. More importantly, the kinetic analysis confirms that sulfur/silicon oxide co‐loading can improve the Li+ diffusion coefficient in CNT anode and enhance the metal ion storage. The structural modifications also enhance Na+ ion storage and the CNT/S/Silicon oxide anode delivers 368 mAh g−1 after 250 cycles at a current rate of 1 A g−1 with a superior initial coulombic efficiency of 77.5 %.
Methylation Induces a Low‐energy Emissive State in N6‐methyladenine Containing Dinucleotides
Authors: Wang Danhong , Jia Menghui , He Xiaoxiao , Pan Haifeng , Chen Jinquan 
Published: January 2024

AbstractMethylation of adenine at the N6 position is a crucial epigenetic modification that profoundly influences gene regulation and expression. Moreover, this modification intricately alters the excited state dynamics of adenine nucleobases. To explore the impact of N6‐methyladenine on the excited state dynamics within oligonucleotides, we conducted a comprehensive investigation of two dinucleotides containing N6‐methyladenosine, in conjunction with adenosine or guanosine. Using steady‐state and time‐resolved absorption and fluorescence spectroscopy techniques, we not only observed the customary monomer‐like and charge transfer emissive states, as reported in previous dinucleotides, but also identified an additional low‐energy emissive state. This unique state exhibits an extraordinary Stokes Shift exceeding 2.3 eV and has a relatively long lifetime of 4–5 ns. We propose that this state corresponds to a bonded exciplex state, governed by ground‐state geometries.
Spinocerebellar ataxia 27B: A novel, frequent and potentially treatable ataxia
Authors: Pellerin David , Danzi Matt C. , Renaud Mathilde , Houlden Henry , Synofzik Matthis , Zuchner Stephan , Brais Bernard 
Published: January 2024

AbstractHereditary ataxias, especially when presenting sporadically in adulthood, present a particular diagnostic challenge owing to their great clinical and genetic heterogeneity. Currently, up to 75% of such patients remain without a genetic diagnosis. In an era of emerging disease‐modifying gene‐stratified therapies, the identification of causative alleles has become increasingly important. Over the past few years, the implementation of advanced bioinformatics tools and long‐read sequencing has allowed the identification of a number of novel repeat expansion disorders, such as the recently described spinocerebellar ataxia 27B (SCA27B) caused by a (GAA)•(TTC) repeat expansion in intron 1 of the fibroblast growth factor 14 (FGF14) gene. SCA27B is rapidly gaining recognition as one of the most common forms of adult‐onset hereditary ataxia, with several studies showing that it accounts for a substantial number (9–61%) of previously undiagnosed cases from different cohorts. First natural history studies and multiple reports have already outlined the progression and core phenotype of this novel disease, which consists of a late‐onset slowly progressive pan‐cerebellar syndrome that is frequently associated with cerebellar oculomotor signs, such as downbeat nystagmus, and episodic symptoms. Furthermore, preliminary studies in patients with SCA27B have shown promising symptomatic benefits of 4‐aminopyridine, an already marketed drug. This review describes the current knowledge of the genetic and molecular basis, epidemiology, clinical features and prospective treatment strategies in SCA27B.
Combining TIGIT blockade with IL‐15 stimulation is a promising immunotherapy strategy for lung adenocarcinoma
Authors: Luo Baohong , Sun Yu , Zhan Qinru , Luo Yuting , Chen Yu , Fu Tongze , Yang Tiantian , Ren Lijuan , Xie Zhongpeng , Situ Xiaohua , Liu Bixia , Tang Kejing , Ke Zunfu 
Published: January 2024

AbstractBackgroundT‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) is an immune checkpoint molecule that suppresses CD8+ T‐cell function in cancer. However, the expression profile and functional significance of TIGIT in the immune microenvironment of lung adenocarcinoma (LUAD) remain elusive. Interleukin (IL)‐15 has emerged as a promising candidate for enhancing CD8+ T‐cell mediated tumour eradication. Exploring therapeutic strategies that combine IL‐15 with TIGIT blockade in LUAD is warranted.MethodsWe investigated the regulatory network involving coinhibitory TIGIT and CD96, as well as costimulatory CD226 in LUAD using clinical samples. The potential role of TIGIT in regulating the pathogenesis of LUAD was addressed through a murine model with transplanted tumours constructed in Tigit−/− mice. The therapeutic strategy that combines TIGIT blockade with IL‐15 stimulation was verified using a transplanted tumour murine model and a patient‐derived organoid (PDO) model.ResultsThe frequency of TIGIT+CD8+ T cells was significantly increased in LUAD. Increased TIGIT expression indicated poorer prognosis in LUAD patients. Furthermore, the effector function of TIGIT+CD8+ tumour‐infiltrating lymphocytes (TILs) was impaired in LUAD patients and TIGIT inhibited antitumour immune response of CD8+ TILs in tumour‐bearing mice. Mechanistically, IL‐15 enhanced the effector function of CD8+ TILs but stimulated the expression of TIGIT on CD8+ TILs concomitantly. The application of IL‐15 combined with TIGIT blockade showed additive effects in enhancing the cytotoxicity of CD8+ TILs and thus further increased the antitumour immune response in LUAD.ConclusionsOur findings identified TIGIT as a promising therapeutic target for LUAD. LUAD could benefit more from the combined therapy of IL‐15 stimulation and TIGIT blockade.
Microwave electrothermal thruster with surface wave plasma
Authors: Kiss'ovski Zhivko , Yordanov Velin , Marinov Simeon , Popov Georgi , Ivanov Stoil 
Published: January 2024

AbstractA new microwave electrothermal thruster (MET) with small dimensions (length of 25 mm and diameter of 6 mm), utilizing surface wave (SW) plasma at low average power consumption Pav ˜ 2 W, is made. It uses microwaves at a frequency of 2.45 GHz for plasma generation within a dielectric chamber enclosed in a metal shield. The SW is excited at the plasma‐dielectric interface by a coaxial launcher and a standing wave is created due to the wave reflection from the shield. The high‐density plasma produced in this resonant chamber heats up the argon gas, which expands through the nozzle in the axial direction. The temperature of the gas decreases from 1900 K at atmospheric pressure to 1200 K at 10 Torr ambient pressure. This small‐sized MET shows stable low‐pressure operation with a thrust of 4 mN and an efficiency of 8% and is suitable for nanosatellite orbit control.
Dendrobine regulates STAT3 to attenuate mitochondrial dysfunction and senescence in vascular endothelial cells triggered by oxidized low‐density lipoprotein
Authors: Xia Jia , Chen Jingyi , Xing Xinyue , Meng Jing , Song Xiaoying , Lou Danfei 
Published: January 2024

AbstractOur previous studies have highlighted the potential therapeutic efficacy of dendrobine, an alkaloid, in atherosclerosis (AS), nevertheless, the underlying mechanism remains unclear. This study employs a combination of network pharmacology and in vitro experiments to explore the regulatory pathways involved. Through network pharmacology, the biological function for intersection targets between dendrobine and AS were identified. Molecular docking was conducted to investigate the interaction between the dominant target and dendrobine. Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low‐density lipoprotein (ox‐LDL) to mimic AS, and the effects of dendrobine on cell viability, lipid deposition, mitochondrial function, and cellular senescence were evaluated. Subsequently, cells were treated with the mitophagy inhibitor Mdivi‐1 and the STAT3 agonist colivelin to assess the role of mitophagy and STAT3 signaling in dendrobine regulation. Intersection targets were associated with biological processes, including reactive oxygen species production. Dendrobine attenuated the effects of ox‐LDL treatment on HUVECs, mitigating changes in cell activity, lipid deposition, mitochondrial function, and cellular senescence. Both Mdivi‐1 and colivelin treatments resulted in decreased cell viability and increased cellular senescence, with colivelin suppressing mitophagy. Cotreatment with Mdivi‐1 and colivelin further aggravated cellular senescence and inhibited FoxO signaling. Together, this study indicated that dendrobine regulated the STAT3/FoxO signaling pathway, alleviating mitochondrial dysfunction and cellular senescence. This study contributes valuable insights to the potential clinical application of dendrobine.
Promoting Resilience to Improve Disordered Eating (PRIDE): A case series of an eating disorder treatment for sexual minority individuals
Authors: Brown Tiffany A. , Klimek‐Johnson Patrycja , Siegel Jaclyn A. , Convertino Alexandra D. , Douglas Valerie J. , Pachankis John , Blashill Aaron J. 
Published: January 2024

AbstractObjectiveDespite the increased risk for eating disorders (EDs) among sexual minority (SM) individuals, no ED treatments exist specifically for this population. SM stress and appearance‐based pressures may initiate and/or maintain ED symptoms in SM individuals; thus, incorporating strategies to reduce SM stressors into existing treatments may help address SM individuals' increased ED risk. This mixed‐methods study evaluated the feasibility, acceptability, and preliminary efficacy of Promoting Resilience to Improve Disordered Eating (PRIDE)—a novel ED treatment for SM individuals.MethodsN = 14 SM individuals with an ED diagnosis received 14 weekly sessions integrating Enhanced Cognitive Behavioral Therapy for EDs (CBT‐E) with techniques and principles of SM‐affirmative CBT developed to address SM stressors. Participants completed qualitative interviews and assessments of ED symptoms and SM stress reactions at baseline (pretreatment), posttreatment, and 1‐month follow‐up.ResultsSupporting feasibility, 12 of the 14 (85.7%) enrolled participants completed treatment, and qualitative and quantitative data supported PRIDE's acceptability (quantitative rating = 3.73/4). By 1‐month follow‐up, 75% of the sample was fully remitted from an ED diagnosis. Preliminary efficacy results suggested large and significant improvements in ED symptoms, clinical impairment, and body dissatisfaction, significant medium‐large improvements in internalized stigma and nonsignificant small‐medium effects of sexual orientation concealment.DiscussionInitial results support the feasibility, acceptability, and initial efficacy of PRIDE, an ED treatment developed to address SM stressors. Future research should evaluate PRIDE in a larger sample, compare it to an active control condition, and explore whether reductions in SM stress reactions explain reductions in ED symptoms.Public SignificanceThis study evaluated a treatment for SM individuals with EDs that integrated empirically supported ED treatment with SM‐affirmative treatment in a case series. Results support that this treatment was well‐accepted by participants and was associated with improvements in ED symptoms and minority stress outcomes.
Using macroinvertebrate‐based biotic indices and diversity indices to assess water quality: A case study on the Karasu Stream (Kastamonu, Türkiye)
Authors: Etriieki Abdulhamed M. Omar , Küçükbasmacı İbrahim 
Published: January 2024

AbstractBiomonitoring is an approach that uses indicators or sentinel species to assess the health or pollution of an environment, combining diversity based on specific taxonomic groups with the taxa's indicator of pollution into a single index or score. Benthic macroinvertebrates are among the most preferred and valuable indicators of the biotic index. Our study aims to evaluate water quality and ecological status using biotic and diversity indices based on benthic macroinvertebrates. The macroinvertebrate samples used in this study were collected seasonally from 16 stations determined in Karasu Stream. These samples consist of 14,747 specimens belonging to 9 orders and 40 families of Insecta, Malacostraca, Hirudinea and Oligochaeta. In addition, some physicochemical parameters were measured at the stations. The data obtained were analysed using the Turkey‐Biological Monitoring Working Group (TR‐BMWP), Average Score per Taxon (ASPT), Family Biotic Index (FBI), Ephemeroptera, Plecoptera and Trichoptera (EPT) taxon richness index, and Shannon–Wiener, Simpson and Hill's diversity indices. Our results showed that the last six stations of Karasu Stream were under pressure due to various anthropogenic effects. According to biotic indexes, the ecological quality status of the water in the stations was determined to be high or good in the first 10 stations and average, poor or bad in the last 6 stations. The results of our study showed that TR‐BMWP, FBI and EPT indices are more reliable in determining water quality than the ASPT index and reflect the environmental situation better. Since the TR‐BMWP index is adapted to macroinvertebrate taxa distributed in Türkiye, it can be used as a suitable tool for evaluating other rivers' water quality in Türkiye.
Estimating the clinical and budgetary impact of using angiotensin receptor neprilysin inhibitor as first line therapy in patients with HFrEF
Authors: Bergh Nicklas , Lindmark Krister , Lissdaniels Johannes , Lanne Gustav , Käck Oskar , Cowie Martin R. 
Published: January 2024

AbstractAimsRecent updates of international treatment guidelines for heart failure with reduced ejection fraction (HFrEF) differ regarding the use of angiotensin receptor neprilysin inhibitor (ARNI) as first‐line treatment. The American Heart Association/American College of Cardiology/Heart Failure Society of America (AHA/ACC/HFSA) 2022 guidelines gives ARNI a Class IA recommendation for HFrEF patients while the European Society of Cardiology's guidelines are less clear when ARNI could be considered as first line treatment option in de novo patients. This study aimed to model the clinical and budgetary outcomes of implementing these guidelines, comparing conservative ARNI prescription patterns with less conservative in Sweden and in the United Kingdom.Methods and resultsA health economic model was developed to compare different treatment patterns for HFrEF. Incident cohorts were included on an annual basis and followed over 10 years. The model included treatment specific all‐cause mortality and hospitalization rates, as well as drug acquisition, monitoring, and hospitalization costs. Increasing the use of ARNI could lead to about 7000–12 300 life years gained and 2600–4600 hospitalizations prevented in Sweden. These health benefits come with an additional cost of 112–195 million euros. Similar results were estimated for the United Kingdom, albeit on a larger population.ConclusionsIncreasing the proportion of patients receiving ARNI instead of angiotensin converting enzyme inhibitors as first‐line treatment of HFrEF will lead to a considerable number of additional life years gained and prevented hospitalizations but with additional cost in terms of health care expenditure in Sweden and in the United Kingdom.