bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Dictator Clubs Constrain Regional Challengers
Authors: Debre Maria J 
Published: February 2025

Abstract
Chapter 6 investigates how dictator clubs prevent interference by other regional actors such as neighboring states, regional civil society, or the regional organization (RO) bureaucracy on the side of democratic challengers, and why they do not protect dictators who face intra-elite challengers. The chapter focuses on regional challenges to the regime in Zimbabwe from 2002 to 2017, and how norms of sovereignty and non-interference practiced by the Southern African Development Community (SADC) helped to keep President Mugabe in power. The chapter also shows how the same logic led to Mugabe’s downfall in 2017 when he was replaced by a former ally in a military coup.
Conclusion
Authors: Debre Maria J 
Published: February 2025

Abstract
The concluding chapter summarizes key findings to recap when, how, and under which conditions dictator clubs benefit the survival of authoritarian regimes across time and world regions. It then discusses important implications for world politics, particularly the state of the liberal international order and for the future development of democracy across the globe. Dictator clubs are increasingly engaged on the international stage to coordinate positions and challenge established multilateral institutions. With growing challenges to democracy both from reinforcement of authoritarian rule by dictator clubs and from democratic backsliding, and a global retreat of US hegemonic power, the fate of democracy remains more unclear than ever.
Early Modern Women’s Writing and the Future of Literary History
Authors: Dodds Lara , Dowd Michelle M 
Published: February 2025

Abstract
This book demonstrates that a full accounting of early modern women’s literary and creative activities is required for the future of literary studies writ large. Providing evidence of not only the relevance but the necessity of early modern women’s writing to the larger field of English literature, it argues that critical questions raised by early modern women’s writing provide opportunities to rethink enduring topics of scholarly interest. In its state-of-the-field assessment, it examines how perennial questions about authorship, canon, and literary value have historically influenced scholarship on early modern women’s writing and its place within literary studies. In both the classroom and in scholarship, early modern women’s writing shows the way forward for the field, whether in the renewal of formalist approaches to literature through an alliance with feminism or in the integration of newer critical methodologies such as premodern critical race studies. This book demonstrates that a feminist literary history that places women’s writing at its center is essential to the future of English Renaissance literary studies. There is, in other words, no history of English Renaissance literature without women writers.
Premodern Critical Race Studies and Women’s Writing
Authors: Dodds Lara , Dowd Michelle M 
Published: February 2025

Abstract
This chapter recounts the critical histories that have helped establish a divide between scholarship on early modern women’s writing and scholarship on premodern critical race studies, and it posits several strategies for bringing these fields into closer alignment. The chapter is governed by two central questions: (1) Why is the study of race crucial to understanding early modern women’s writing? and (2) What might the study of early modern women’s writing offer to premodern critical race studies that is distinctive? The chapter argues that analyses of racialization in early modern women’s texts can open up new possibilities for understanding these works as part of England’s broader cultural and literary history and can also generate important new perspectives on the racial logics at work in the premodern past—perspectives that could go unnoticed if scholars focus exclusively on male authors.
A Social Identity Approach to Blue-Collar Worker Support for the Populist Radical Right
Authors: Castater Eric G , Han Kyung Joon 
Published: February 2025

Abstract
This chapter reviews scholarly works on the determinants of populist radical right support and social identity, outlines our social identity approach to blue-collar worker support for the populist radical right, and provides preliminary tests of our theoretical claims. The first section of the chapter provides a broad overview of the literature on the determinants of populist radical right support with an emphasis on the importance of policymaking processes, policy outputs, and policy outcomes. The second section reviews the literature on social identity. The third section outlines the three-stage theory explaining blue-collar worker support for the populist radical right. The fourth section conducts preliminary tests of each stage in our theory: the effect of political and economic contexts on national identity; the effect of national identity on issue salience; and the effect of issue salience on populist radical right support.
Understanding polypharmacy for people receiving home care services: a scoping review of the evidence
Authors: Karimi Radin , Robinson-Barella Anna , Davey Vanessa , Sinclair David R , Hanratty Barbara , Todd Adam 
Published: February 2025

Abstract

Background
Polypharmacy, defined as the concurrent use of five or more medications, is common amongst older adults receiving home care services. The relationship between home care and polypharmacy may be critical to older people’s health, but there is little research on this topic.

Objective
To understand the extent and type of evidence on individuals receiving home care services and experiencing polypharmacy.

Methods
This review followed the Preferred Reporting of Items for Systematic Reviews and Meta-Analyses extension for scoping reviews. Three databases (MEDLINE, Embase, CINAHL) were systematically searched (December 2023) to identify studies with adult participants experiencing polypharmacy and receiving home care.

Results
Twenty-three studies were included. For individuals receiving home care services, the studies reported on the following: (i) prevalence of polypharmacy, (ii) interventions to reduce inappropriate polypharmacy, (iii) perceived role of home care workers, (iv) assessment of health literacy in individuals experiencing polypharmacy, and (v) factors associated with polypharmacy and potentially inappropriate medications (PIMs). Polypharmacy and PIMs were found to be associated with older age, female sex, increased frailty, living alone, poor economic situation and inaccuracies within medical records. Improved appropriateness of prescribing can be achieved through interprofessional interventions, efficient use of home care workers and improved health literacy.

Conclusion
This review highlights research on the extent of polypharmacy in home care and ways to address it. Whilst there are suggestions for enhancing medication quality, key gaps remain in research into the experiences of care staff and recipients in managing medications and polypharmacy, which should be addressed.
Cell-type deconvolution for bulk RNA-seq data using single-cell reference: a comparative analysis and recommendation guideline
Authors: Xu Xintian , Li Rui , Mo Ouyang , Liu Kai , Li Justin , Hao Pei 
Published: February 2025

Abstract
The accurate estimation of cell type proportions in tissues is crucial for various downstream analyses. With the increasing availability of single-cell sequencing data, numerous deconvolution methods that use single-cell RNA sequencing data as a reference have been developed. However, a unified understanding of how these deconvolution approaches perform in practical applications is still lacking. To address this, we systematically assessed the accuracy and robustness of nine deconvolution methods that use single-cell RNA sequencing data as a reference, evaluating them on real bulk data with cell proportions verified through flow cytometry, as well as simulated bulk data generated from five single-cell RNA sequencing datasets. Our study highlights the importance of several factors—including reference dataset construction strategies, dataset size, cell type subdivision, and cell type inconsistency—on the accuracy and robustness of deconvolution results. We also propose a set of recommended guidelines for software users in diverse scenarios.
Accurate, comprehensive database of group I introns and their homing endonucleases
Authors: Sellés Vidal Lara , Noma Tomoya , Yokobayashi Yohei 
Published: February 2025

Abstract

Motivation
Group I introns are one of the most widely studied ribozymes. Since their initial discovery, a large number of them have been identified experimentally or computationally. However, no comprehensive and unified database that provides group I intron sequences with precise boundaries and structural information is available.

Results
We created a new database of group I intron sequences with reliable exon-intron boundaries. The database offers additional data for each sequence, such as containing GenBank entry, its position within the associated entry, the subtype of each intron and putative homing endonucleases. Secondary structure predictions and base-pairing probability matrixes are also provided for each sequence. The resource is expected to facilitate large-scale studies of group I introns, as well as engineering for novel applications.

Availability and implementation
The database, as well as the code to generate it and a GUI to facilitate its exploration, are available at https://github.com/LaraSellesVidal/Group1IntronDatabase. The source code for the GUI implementation is available at https://github.com/LaraSellesVidal/OnlineGroup1IntronDatabase. The database can also be accessed online at https://online-group-1-intron-database.onrender.com. Base-pairing probability matrixes are available separately at https://www.ebi.ac.uk/biostudies/studies/S-BSST1399.
Successive cycles of allopatric differentiation and secondary contact shape phylogeographical structure in an Indo-West Pacific reef fish
Authors: Hsu Ling-Lan , Borsa Philippe , Chen Wei-Jen 
Published: February 2025

Abstract
Geographical barriers and sea-level fluctuations have significantly influenced the population genetic structure and evolutionary history of Indo-West Pacific (IWP) reef species. This study examines these effects in Abudefduf septemfasciatus (banded sergeant), a widely distributed egg-brooding IWP damselfish. Using 4700 genome-wide single nucleotide polymorphisms obtained from double-digest restriction site-associated DNA sequencing and a 1638-bp mitochondrial gene fragment from 106 samples across six IWP locations, we identified two main genetic clusters: one in the Indian Ocean and another in the Pacific Ocean. Within the Pacific, two distinct subclusters were detected, with overlapping ranges in Taiwan. Demographic analysis of the dataset using two-population genetic models in ∂a∂I, based on diffusion approximation, revealed asymmetric gene flow, with stronger migration from the Indian Ocean to the Pacific. Recurrent episodes of isolation and secondary contact during Pleistocene glacial cycles further shaped these genetic patterns. Our findings provide new insights into the complex phylogeography and evolutionary dynamics of banded sergeants, contributing to a broader understanding of how historical environmental changes have driven the diversification of IWP reef fishes.
Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits
Authors: de Longprez Lucie , Gaillard Marie-Claude , Decraene Charles , Perot Jean-Baptiste , Keime Celine , Nadkarni Nachiket , Louça Mathilde , Jan Caroline , Liot Géraldine , Aurégan Gwennaëlle , Guillermier Martine , Mitja Julien , Hantraye Philippe , Bertaux Fabien , Norbert Marie , Bonvento Gilles , Flament Julien , Dhenain Marc , Neri Christian , Bemelmans Alexis-Pierre , Mérienne Karine , Cambon Karine , Brouillet Emmanuel 
Published: February 2025

Abstract
DCLK3 (Doublecortin-like kinase 3) is a kinase preferentially expressed in neurons. Dclk3 variants are risk factors for psychiatric disorders and brain alterations linked to age-related mild cognitive impairment, suggesting this kinase could be important to cognition. However, the physiological role of DCLK3 remains unknown.
Here, we generated and characterized mice with constitutive or brain-region specific Dclk3 knockout.
We found that constitutive pan-deletion of Dclk3 is associated with an anxiety phenotype in male, associated with changes in brain metabolites in absence of major neuroanatomical alterations, motor or memory deficits. Moreover, virally mediated loco-regional conditional Dclk3 knockout in the dorsal hippocampus of adult mice led to spatial memory deficits and transcriptomic changes, characterized by increased expression of α2, β1, and β2 subunits of the GABAA receptor, down-regulation of neuronal activity-regulated genes such as the immediate early genes (e.g. Egr1, Fos, Per1 and Nr4r1), and transcriptional regulator-activity enriched in polycomb-repressive complexes (PRC).
These new data reveal that Dclk3 modulates behavior and cognition in association with transcriptomic changes in the hippocampus, providing direct physiological evidence that this kinase is involved in synaptic plasticity, consistent with its crucial role in neurodegenerative and psychiatric diseases.
The inflammatory APRIL (a proliferation-inducing ligand) antagonizes chondroitin sulphate proteoglycans to promote axonal growth and myelination
Authors: Ahmed Mashal Claude , Kakunuri Tejaswini , Peris Leticia , Meffre Delphine , Yilmaz Elif Nur , Grewing Laureen , Guerrero González Raquel , Manfroi Benoit , Gout Evelyne , Vivès Romain R , Fitzgerald Una , Schneider Pascal , Jafarian-Tehrani Mehrnaz , Kuhlmann Tanja , Huard Bertrand 
Published: February 2025

Abstract
Lesions in the CNS are frequently associated to a detrimental inflammatory reaction. In autoimmune neurodegenerative diseases, a proliferation-inducing ligand (APRIL) produced by CNS-infiltrating inflammatory cells binds to chondroitin sulphate proteoglycans (CSPGs). The latter are well-established obstacles to neural regeneration and remyelination in the CNS by interacting with receptor protein tyrosine phosphatase (RPTP) and Nogo receptor (NgR) families. Here, we are showing that APRIL blocks the interactions of RPTP and NgR with all types of chondroitin sulphate (CS). Functionally, APRIL neutralized the inhibitory effects of CS on mouse and human neuronal process growth. APRIL also blocked the inhibition of CS on mouse and human oligodendrocyte differentiation. Finally, APRIL increased myelination in an ex vivo organotypic model of demyelination in the presence of endogenous CSPG upregulation. Our data demonstrate the potential value for a recombinant form of soluble APRIL to achieve repair in the CNS.
Bifocal tACS over the primary sensorimotor cortices increases interhemispheric inhibition and improves bimanual dexterity
Authors: Lebihan Brooke , Mobers Lauren , Daley Shannae , Battle Ruth , Leclercq Natasia , Misic Katherine , Wansbrough Kym , Vallence Ann-Maree , Tang Alexander , Nitsche Michael , Fujiyama Hakuei 
Published: February 2025

Abstract
Concurrent application of transcranial alternating current stimulation over distant cortical regions has been shown to modulate functional connectivity between stimulated regions; however, the precise mechanisms remain unclear. Here, we investigated how bifocal transcranial alternating current stimulation applied over the bilateral primary sensorimotor cortices modulates connectivity between the left and right primary motor cortices (M1). Using a cross-over sham-controlled triple-blind design, 37 (27 female, age: 18 to 37 yrs) healthy participants received transcranial alternating current stimulation (1.0 mA, 20 Hz, 20 min) over the bilateral sensorimotor cortices. Before and after transcranial alternating current stimulation, functional connectivity between the left and right M1s was assessed using imaginary coherence measured via resting-state electroencephalography and interhemispheric inhibition via dual-site transcranial magnetic stimulation protocol. Additionally, manual dexterity was assessed using the Purdue pegboard task. While imaginary coherence remained unchanged after stimulation, beta (20 Hz) power decreased during the transcranial alternating current stimulation session. Bifocal transcranial alternating current stimulation but not sham strengthened interhemispheric inhibition between the left and right M1s and improved bimanual assembly performance. These results suggest that improvement in bimanual performance may be explained by modulation in interhemispheric inhibition, rather than by coupling in the oscillatory activity. As functional connectivity underlies many clinical symptoms in neurological and psychiatric disorders, these findings are invaluable in developing noninvasive therapeutic interventions that target neural networks to alleviate symptoms.
The Taxing Challenges of the State: Unveiling the Role of Fiscal and Administrative Capacity in Development
Authors: Braccioli Federica , Muñoz-Sobrado Esteban , Piolatto Amedeo , Zerbini Antoine 
Published: February 2025

Abstract
The growing emphasis on nation-states and their pivotal role in economic development has emerged as a central theme in contemporary economic discourse. This review examines the concept of state capacity as discussed in the economic literature, focusing on its practical implications. While the definition of state capacity remains multifaceted, this analysis delves into its economic implications. We focus primarily on the literature surrounding fiscal capacity, exploring how a state’s ability to raise and manage revenue impacts economic development and other critical economic outcomes. This review aims to shed light on the crucial role of fiscal capacity in shaping economic performance, inspiring further research and policy development in this area. (JEL codes: D72, D73, D74, E62, H11, H20, H77, and H83)
Non-invasive markers of hepatic steatosis and fibrosis following INSTI initiation in women with HIV
Authors: Yu Michael Andrew , Gerig Logan , Mehta C Christina , Musonge-Effoe Joffi , Alvarez Jessica A , Ofotokun Igho , Sheth Anandi N , Ali Mohammed K , Ziegler Thomas R , Yang Qian , Spence Amanda B , Alcaide Maria L , Dumond Julie B , Abraham Alison G , French Audrey L , Augenbraun Michael , Anastos Kathryn , Price Jennifer C , Tien Phyllis C , Lahiri Cecile D 
Published: February 2025

Abstract

Background
The impact of integrase strand-transfer inhibitors (INSTIs) on steatotic liver disease in women with HIV (WWH) is unknown.

Methods
Using data collected in the Women’s Interagency HIV Study from 2007-2020, change in Fibrosis-4 index (FIB4), aspartate aminotransferase to platelet ratio index (APRI), and non-alcoholic fatty liver disease fibrosis score (NFS) over 5 years was compared between virologically-suppressed WWH who switched to or added an INSTI to their antiretroviral therapy (ART) and WWH remaining on non-INSTI ART. In participants with transient elastography (TE) measures, estimates of hepatic steatosis (controlled attenuation parameter, CAP), fibrosis (liver stiffness, LS), and steatohepatitis (FibroScan-aspartate aminotransferase scores, FAST) were compared by group.

Results
A total of 872 WWH (323 INSTI, 549 non-INSTI) were included, and 280 (146 INSTI, 134 non-INSTI) had TE. Of these, 61% were Non-Hispanic Black; mean age was 47 years and body mass index was 31.4 kg/m2. Among non-obese women, those in the INSTI compared to the non-INSTI group had a greater increase in NFS (but not FIB4 or APRI) over time (study group*time, p=0.015). Those in the INSTI compared to non-INSTI group also had greater CAP (+25, 95%CI:0.28-49, p=0.048), LS (+1.23, 1.01-1.49, p=0.038), and FAST scores (+1.97, 1.17-3.31, p=0.011) and a 3.7 (1.2-11.4, p=0.021) greater odds of having hepatic steatosis (CAP≥248 dB/m) within 1 year of starting an INSTI.

Conclusions
Hepatic steatosis risk was increased only within the first year following INSTI initiation among WWH. Longitudinal hepatic assessments are warranted to evaluate whether these changes are associated with clinically significant liver disease.
A scoring system for diagnosing heart failure with preserved ejection fraction based on exercise echocardiography
Authors: Kagami Kazuki , Harada Tomonari , Yuasa Naoki , Tani Yuta , Murakami Fumitaka , Saito Yuki , Naito Ayami , Okuno Takahiro , Kato Toshimitsu , Takama Noriaki , Wada Naoki , Adachi Takeshi , Ishii Hideki , Obokata Masaru 
Published: February 2025

Abstract

Aims
Exercise stress echocardiography (ESE) is often used to identify heart failure with preserved ejection fraction (HFpEF) in patients presenting dyspnoea. However, diagnostic criteria have not been standardized. Here, we sought to develop ESE-based criteria to diagnose HFpEF in dyspnoeic patients.

Methods and results
A total of 81 consecutive patients with dyspnoea who underwent exercise right heart catheterization and ESE were evaluated. Diagnosis of HFpEF was ascertained by directly-measured haemodynamics (61 HFpEF and 20 controls). Logistic regression analysis was applied to develop an ESE-based scoring system to diagnose HFpEF. Multivariable logistic regression analysis identified resting left atrial reservoir strain &lt; 20%, exercise septal E/e′ ratio &gt; 13, and increases in ultrasound B-lines as independent predictors of HFpEF. A weighted score was created with these variables (the ESE score) ranging from 0 to 5. The ESE score accurately discriminated HFpEF from controls [area under the curve (AUC) 0.90, P &lt; 0.0001], with a superior diagnostic ability to the ASE/ESCVI criteria (AUC comparison P &lt; 0.0001). The ESE score classified the HFpEF probability into three categories (probabilities: low risk 28%, intermediate risk 59–83%, and high risk 95–99%). In a cohort of 620 dyspnoeic patients, the predictive ability of the derived score was assessed. A higher ESE score was associated with an increased risk of all-cause mortality or worsening HF events even after adjusting for confounders (hazard ratio; 1.17 per 1-point increase, 95% confidence intervals; 1.00–1.37, P = 0.04).

Conclusion
The ESE score, which is based on three echocardiographic variables, may be an effective tool for diagnosing HFpEF on exercise echocardiography.