bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Spent Yeast Streams from Precision Fermentations Driven by Genetically Engineered Yeasts: Valorization Potential for a Circular Bioeconomy
Authors: Deuchande Teresa , Fundo Joana F. , Rodrigues Daniela , Pintado Manuela E. , Amaro Ana L. 
Published: January 2024

AbstractCurrently, valuable biomolecules are sustainably produced through fermentation using genetically modified microorganisms. However, this industry also generates several waste streams, such as spent yeast (SY). To close the sustainability loop in bioproduction, it is essential to define valorization strategies for such waste streams. Hence, this study aimed to investigate the compositional differences among these novel SYs, intending to pave the way for devising highly effective and beneficial valorization strategies for these streams. In this work, SYs derived from the production of beer (SBY) and six biomolecules [β-farnesene (Fene), rebaudioside M (Reb M), manool (MN), patchouli (PAT), sandalwood (SDW), and sclareol (SCL)] through fermentations driven by engineered yeasts were characterized. The results showed that SY from Fene, MN, and PAT production have similar concentrations of protein (35.9–44% dw), minerals, and amino acids, being compatible with bulking and use as nitrogen sources. Those derived from Reb M production showed significantly higher levels of lipids (21 ± 2.6% dw) compared to all the other SYs (1.7–10.8% dw), whereas the ones derived from SCL production showed significantly higher levels of inorganic matter (45%) compared with those found in the other SYs (1.2–11.3% dw). The results showed that assessing the extent of compositional variation among different SYs derived from precision fermentations represents a primary step toward developing efficient valorization or biorefining strategies.
Graphical Abstract
Wilder rangelands as a natural climate opportunity: Linking climate action to biodiversity conservation and social transformation
Authors: Simba Lavhelesani D. , te Beest Mariska , Hawkins Heidi-Jayne , Larson Keith W. , Palmer Anthony R. , Sandström Camilla , Smart Kathleen G. , Kerley Graham I. H. , Cromsigt Joris P. G. M. 
Published: January 2024

AbstractRangelands face threats from climate and land-use change, including inappropriate climate change mitigation initiatives such as tree planting in grassy ecosystems. The marginalization and impoverishment of rangeland communities and their indigenous knowledge systems, and the loss of biodiversity and ecosystem services, are additional major challenges. To address these issues, we propose the wilder rangelands integrated framework, co-developed by South African and European scientists from diverse disciplines, as an opportunity to address the climate, livelihood, and biodiversity challenges in the world’s rangelands. More specifically, we present a Theory of Change to guide the design, monitoring, and evaluation of wilder rangelands. Through this, we aim to promote rangeland restoration, where local communities collaborate with regional and international actors to co-create new rangeland use models that simultaneously mitigate the impacts of climate change, restore biodiversity, and improve both ecosystem functioning and livelihoods.
Improved Catalytic Properties of Fluorine-Doped La0.6Sr0.4Co0.2Fe0.8O3-δ for Air Electrode with High-Performance Metal-Air Batteries
Authors: Kim Jiyoun , Lee Jeongah , Kim Sangwoo , Jung WooChul 
Published: January 2024

AbstractLa0.6Sr0.4Co0.2Fe0.8O3-δ (LSCF), a perovskite material, is widely recognized as an excellent catalyst for the oxygen evolution reaction (OER). An anion doping strategy was implemented to enhance the presence of highly oxidation-active O2−/O− species crucial for the electrochemical reaction, effectively replacing oxygen. The introduction of 5 mol% fluorine to LSCF resulted in improved OER performance, comparable to that of commercial noble catalysts. Furthermore, we confirmed that fluorine-doped LSCF enhanced the oxygen reduction reaction (ORR) performance, establishing its effectiveness as a bifunctional catalyst. Moreover, when utilized as an air electrode in a homemade zinc-air battery cell, the electrochemical performance of the doped LSCF remained stable after repeated charge/discharge tests. These findings underscore the potential application of anion doping in electrochemical devices.
Graphical Abstract
Fabrication and validation of flexible neural electrodes based on polyimide tape and gold sheet
Authors: Jeong Hyunbeen , Lee Taekyung , Kim Jisung , Jeong Hee Soo , Jun Sang Beom , Seo Jong-Mo 
Published: January 2024

AbstractThis research was conducted to apply polyimide tape, which has the advantages of low price ans strong adhesive strength, to the neural electrode process. In addition, to maximize the low-cost characteristics, a fabrication process based on UV laser patterning rather than a photolithography process was introduced. The fabrication process started by attaching the gold sheet on the conductive double-sided tape without being torn or crushed. Then, the gold sheet and the double-sided tape were patterned together using UV laser. The patterned layer was transferred to the single-side polyimide tape. For insulation layer, electrode site opened single-sided polyimide tape was prepared. Polydimethylsiloxane was used as an adhesion layer, and alignment between electrode sites and opening sites was processed manually. The minimum line width achieved through the proposed fabrication process was approximately 100 $$\mu$$
μ
m, and the sheet resistance of the conductive layer was 0.635 $$\Omega$$
Ω
/sq. Measured cathodal charge storage capacity was 0.72 mC/cm$$^2$$

2

and impedance at 1 kHz was 4.07 k$$\Omega$$
Ω
/cm$$^2$$

2

. Validation of fabricated electrode was confirmed by conducting 30 days accelerated soak test, flexibility test, adhesion test and ex vivo stimulation test. The novel flexible neural electrodes based on single-sided polyimide tape and UV laser patterned gold sheet was fabricated successfully. Conventional neural electrode fabrication processes based on polyimide substrate has a disadvantages such as long fabrication time, expensive costs, and probability of delamination between layers. However, the novel fabrication process which we introduced can overcome many shortcomings of existing processes, and offers great advantages such as simplicity of fabrication, inexpensiveness, flexibility and long-term reliability.
Ultra-processed Food and Obesity: What Is the Evidence?
Authors: Dicken Samuel J. , Batterham Rachel L. 
Published: January 2024

Abstract
Purpose of Review
Obesity is a growing global healthcare concern. A proposed driver is the recent increase in ultra-processed food (UPF) intake. However, disagreement surrounds the concept of UPF, the strength of evidence, and suggested mechanisms. Therefore, this review aimed to critically appraise the evidence on UPF and obesity.

Recent Findings
Observational studies demonstrate positive associations between UPF intake, weight gain, and overweight/obesity, more clearly in adults than children/adolescents. This is supported by high-quality clinical data. Several mechanisms are proposed, but current understanding is inconclusive.

Summary
Greater UPF consumption has been a key driver of obesity. There is a need to change the obesogenic environment to support individuals to reduce their UPF intake. The UPF concept is a novel approach that is not explained with existing nutrient- and food-based frameworks.
Critical analysis of methodologies provides confidence, but future observational and experimental research outputs with greater methodological rigor will strengthen findings, which are outlined.
Review of flexible perovskite solar cells for indoor and outdoor applications
Authors: Goje Adamu Ahmed , Ludin Norasikin Ahmad , Fahsyar Puteri Nor Aznie , Syafiq Ubaidah , Chelvanathan Puvaneswaran , Syakirin Abu Dzar Al-Ghiffari , Teridi Mohd Asri , Ibrahim Mohd Adib , Su’ait Mohd Sukor , Sepeai Suhaila , Yasir Ahmad Shah Hizam Md 
Published: January 2024

AbstractPerovskite solar cells (PSCs) have shown a significant increase in power conversion efficiency (PCE) under laboratory circumstances from 2006 to the present, rising from 3.8% to an astonishing 25%. This scientific breakthrough corresponds to the changing energy situation and rising industrial potential. The flexible perovskite solar cell (FPSC), which capitalizes on the benefits of perovskite thin-film deposition and operates at low temperatures, is key to this transition. The FPSC is strategically important for large-scale deployment and mass manufacturing, especially when combined with the benefits of perovskite thin-film deposition under moderate thermodynamic conditions. Its versatility is demonstrated by the ease with which it may be folded, rolled, or coiled over flexible substrates, allowing for efficient transportation. Notably, FPSCs outperform traditional solar panels in terms of adaptability. FPSCs have several advantages over rigid substrates, including mobility, lightweight properties that help transportation, scalability via roll-to-roll (R2R) deposition, and incorporation into textiles and architecture. This in-depth examination dives into their fundamental design and various fabrication techniques, which include conducting substrates, absorber layers, coordinated charge movement, and conductive electrodes. This review evaluates critical FPSC fabrication techniques such as thermal evaporation, R2R approaches, slot die and spray deposition, blade coating, and spin coating. The present challenges in constructing FPSCs with high performance and long-term stability are also highlighted. Finally, the solar industry's potential uses for both indoor and outdoor FPSCs have been discussed.
The Role of Belief Sources in Promoting Goal Orientation Beliefs, Self-Efficacy, and Beliefs About the Role of Teachers in Mathematics Learning
Authors: Hidayatullah Achmad , Csíkos Csaba , Setiyawan Radius 
Published: January 2024

AbstractGoal orientation beliefs, self-efficacy, and beliefs about the role of the teacher in mathematics learning have been known as important factors in promoting students’ success in mathematics. Beliefs can be shaped through four principles: mastery experience, vicarious experience, social persuasion, and physiological state. This study examined the structural relationship between belief sources, goal orientation beliefs, self-efficacy, and beliefs about the role of mathematics teachers. Seventeen classes were selected randomly within 35 classes from fifth and sixth grade, four private schools in Surabaya, Indonesia. Five hundred-five students participated in the present study. Partial Least Square structural equation modeling was performed to analyze the data. The result showed that mastery experience and vicarious experience positively predicted students’ goal orientation beliefs, self-efficacy, and beliefs about the role of the teachers. Social persuasion significantly influenced self-efficacy and beliefs about the role of mathematics teachers but not goal orientation beliefs. Among the belief sources, social persuasion is the strongest predictor for self-efficacy. Vicarious experience is the most powerful predicator for goal orientation beliefs and beliefs about the role of mathematics teachers. Meanwhile, the physiological state only negatively predicted goal orientation beliefs. The contribution of the findings of our study for mathematical teaching practices in Surabaya-Indonesia was discussed.
Host response of five potato cultivars to Meloidogyne nematodes
Authors: Ramatsitsi Mukondeleli Ndivhuwo , Nxumalo Siphephelo , Ramachela Khosi , Khosa Mbokota Candy 
Published: January 2024

AbstractPotato (Solanum tuberosum L.) is a well-known food crop that is regarded as an important component in the worldwide battle against hunger and malnutrition. Root-knot nematodes (RKN), Meloidogyne species, are a serious limitation in the potato industry. Potato, being a tuberous crop, yield reduction is mainly due to tuber quality and quantity. In order to evaluate the response of five commercial potato cultivars, viz ‘Buffelspoort 1’, ‘Hertha’, ‘Larnoma’, ‘Mnandi’ and ‘Up-to-date’ to two RKN species, viz M. enterolobii and M. javanica; pot experiments were conducted under net house conditions. Ten separate experiments, each with treatments: 0, 500, 1500, 2500 and 3500 eggs + second-stage juveniles (J2), were arranged in a randomized complete block design (RCBD) with five replicates. Fifty-six days after inoculation, nematode effect on plant yield was evaluated. Potato tubers were assessed for root galls, and nematodes reproductive factor (RF) was computed. There were significant differences amongst treatments on the following potato growth parameters: plant height, stem diameter, chlorophyll content, number of tubers and tuber weight in both M. enterolobii and M. javanica (P ≤ 0.05). The RF was above unity (one) in all potato cultivars for both M. enterolobii and M. javanica; with M. enterolobii showing more aggressiveness compared to M. javanica. Further, cultivars ‘Buffelspoort 1’ and ‘Hertha’ showed the highest susceptibility, whilst cultivar ‘Mnandi’ showed the least susceptibility. Infection of potato cultivars by the nematodes had severe effects on growth parameters of all the cultivars. Results suggested that all five commercial potato cultivars were susceptible to M. enterolobii and M. javanica. Thus, there is an urgent need for RKN management intervention in the aforementioned cultivars.
Strong Edge Geodetic Problem on Complete Multipartite Graphs and Some Extremal Graphs for the Problem
Authors: Klavžar Sandi , Zmazek Eva 
Published: January 2024

AbstractA set of vertices X of a graph G is a strong edge geodetic set if, to any pair of vertices from X, we can assign one (or zero) shortest path between them, such that every edge of G is contained in at least one on these paths. The cardinality of a smallest strong edge geodetic set of G is the strong edge geodetic number $$\mathrm{sg_e}(G)$$

sg
e

(
G
)

of G. In this paper, the strong edge geodetic number of complete multipartite graphs is determined. Graphs G with $$\mathrm{sg_e}(G) = n(G)$$

sg
e

(
G
)

=
n

(
G
)

are characterized and $$\mathrm{sg_e}$$

sg
e

is determined for Cartesian products $$P_n\,\square \, K_m$$

P
n

□

K
m

. The latter result in particular corrects an error from the literature.
Relation Between Endothelial Dysfunction and Exercise Training-Mediated Adaptation in Cardiovascular Risk Factors, Cardiorespiratory Fitness, and Vascular Health in Humans: A secondary analysis
Authors: McLellan Hannah L. , Dawson Ellen A. , Hopkins Nicola D. , Jones Helen , Maiorana Andrew J. , Hopman Maria T. E. , Haynes Andrew , Naylor Louise H. , Green Daniel J. , Thijssen Dick H. J. 
Published: January 2024

Abstract
Purpose
A priori cardiovascular (CV) health status may impact reductions in risk factors and CV mortality and morbidity following exercise training, although this is not fully understood. Therefore, the purpose of the study was to examine if endothelial function (assessed via flow mediated dilation; FMD%), predicts the magnitude of change in CV risk factors or fitness following exercise training.

Methods
We pooled data from 338 individuals who underwent supervised exercise training (8–26 weeks). Using recent sex- and age-specific reference values for flow-mediated dilation (FMD%), we categorised participants as having preserved endothelial function (P-EF) (> 50th percentile of reference value, 56 females, 67 males, 46 ± 17 years) or reduced endothelial function (R-EF) (< 50th percentile of reference value, 67 females, 148 males, 48 ± 17 years). The effects of exercise training on cardiovascular risk factors (BMI, cholesterol, glucose and triglycerides), cardiorespiratory fitness (VO2peak) and vascular function (FMD%) were examined using a two-way mixed design general linear model.

Results
Exercise training significantly improved physical fitness (P < 0.001), with no difference in the magnitude of improvement between P-EF and R-EF. Modest but significant reductions were present in BMI, blood pressure and total cholesterol (all P < 0.005), with no difference between P-EF and R-EF groups in the magnitude of changes in these variables with training. Exercise training did not significantly alter glucose, triglycerides, high density lipoprotein (HDL) and low-density lipoprotein (LDL) (all P > 0.05).

Conclusion
Individuals with reduced and preserved a priori endothelial function status can obtain benefits from exercise in terms of risk factor modification and fitness change. Therefore, exercise has the potential to be beneficial in all clinical groups.
A Novel Method to Repair Thin Endometrium and Restore Fertility Based on Menstruation-Derived Stem Cell
Authors: Chen Kai , Wang Huiru , Zhao Xin , Wang Jingxin , Jin Qi , Tong Xianhong , Zheng Shengxia 
Published: January 2024

AbstractThin endometrium (TE), which mainly occurs as a result of severe damage to the endometrial basalis, is one of the prominent etiologies of menstrual abnormalities, infertility, and recurrent miscarriage in women. Previous studies have demonstrated that mesenchymal stem cells (MSCs) are considered ideal cells with multipotency for regenerative medicine and exhibit therapeutic effects on TE through their cellular secretions. However, there is limited research on strategies to enhance MSC secretion to improve their therapeutic efficacy. Herein, we isolated menstrual blood–derived mesenchymal stem cells (MenSCs) from menstruation and transformed them into decidualized stromal cells (DSCs), which are specialized cells with enhanced secretory functions. To assess the therapeutic potential of DSCs compared to MenSCs, we conducted a series of experiments in cells and animals. The results demonstrated that DSCs exhibited changes in morphology compared to MenSCs, with a decrease in cell proliferation but a significant improvement in secretion function. Furthermore, DSCs facilitated the restoration of endometrial thickness and increased the number of glands and blood vessel formation. Most importantly, the pregnancy rates in rats were effectively restored, bringing them closer to normal levels. These findings greatly contribute to our understanding of stem cell therapy for TE and strongly suggest that DSCs could hold significant promise as a potential treatment option for TE.
Fractional Bessel Derivative Within the Mellin Transform Framework
Authors: Bouzeffour Fethi 
Published: January 2024

Abstract
In this paper, we present a fresh perspective on the fractional power of the Bessel operator using the Mellin transform. Drawing inspiration from the work of Pagnini and Runfola, we develop a new approach by employing Tato’s type lemma for the Hankel transform. As an application, we establish a new intertwining relation between the fractional Bessel operator and the fractional second derivative, emphasizing the important role of the Mellin transform in the domain of fractional calculus associated with the Bessel operator.
Research on the influence of flipped classroom on self-efficacy in English language learning of Chinese higher vocational college students
Authors: Han Wei , Hamzah Mahizer 
Published: January 2024

AbstractSelf-efficacy in English language learning is directly correlated with the success of the students in learning English, the models they follow at each level, the encouragement and suggestions received by their groups, and the evaluations their teachers provide them. As an innovation for the traditional teaching method, the flipped classroom teaching model can affect the formation of self-efficacy in English language learning from the above four aspects. It has a theoretically positive promotion of self-efficacy. The study employed a quasi-experimental approach and semi-structured interviews to investigate whether the flipped classroom teaching model has a positive impact on self-efficacy in English language learning of the students of Chinese higher vocational colleges. The results showed that flipped classroom had a significant positive impact on students’ self-efficacy in English language learning.
Lie algebra actions on module categories for truncated shifted yangians
Authors: Kamnitzer Joel , Webster Ben , Weekes Alex , Yacobi Oded 
Published: January 2024

AbstractWe develop a theory of parabolic induction and restriction functors relating modules over Coulomb branch algebras, in the sense of Braverman-Finkelberg-Nakajima. Our functors generalize Bezrukavnikov-Etingof’s induction and restriction functors for Cherednik algebras, but their definition uses different tools.After this general definition, we focus on quiver gauge theories attached to a quiver$\Gamma $. The induction and restriction functors allow us to define a categorical action of the corresponding symmetric Kac-Moody algebra$\mathfrak {g}_{\Gamma }$on category$ \mathcal {O}$for these Coulomb branch algebras. When$ \Gamma $is of Dynkin type, the Coulomb branch algebras are truncated shifted Yangians and quantize generalized affine Grassmannian slices. Thus, we regard our action as a categorification of the geometric Satake correspondence.To establish this categorical action, we define a new class of ‘flavoured’ KLRW algebras, which are similar to the diagrammatic algebras originally constructed by the second author for the purpose of tensor product categorification. We prove an equivalence between the category of Gelfand-Tsetlin modules over a Coulomb branch algebra and the modules over a flavoured KLRW algebra. This equivalence relates the categorical action by induction and restriction functors to the usual categorical action on modules over a KLRW algebra.
Cross-population applications of genomics to understand the risk of multifactorial traits involving inflammation and immunity
Authors: Alamad Bana , Elliott Kate , Knight Julian C. 
Published: January 2024

Abstract
The interplay between genetic and environmental factors plays a significant role in interindividual variation in immune and inflammatory responses. The availability of high-throughput low-cost genotyping and next-generation sequencing has revolutionized our ability to identify human genetic variation and understand how this varies within and between populations, and the relationship with disease. In this review, we explore the potential of genomics for patient benefit, specifically in the diagnosis, prognosis and treatment of inflammatory and immune-related diseases. We summarize the knowledge arising from genetic and functional genomic approaches, and the opportunity for personalized medicine. The review covers applications in infectious diseases, rare immunodeficiencies and autoimmune diseases, illustrating advances in diagnosis and understanding risk including use of polygenic risk scores. We further explore the application for patient stratification and drug target prioritization. The review highlights a key challenge to the field arising from the lack of sufficient representation of genetically diverse populations in genomic studies. This currently limits the clinical utility of genetic-based diagnostic and risk-based applications in non-Caucasian populations. We highlight current genome projects, initiatives and biobanks from diverse populations and how this is being used to improve healthcare globally by improving our understanding of genetic susceptibility to diseases and regional pathogens such as malaria and tuberculosis. Future directions and opportunities for personalized medicine and wider application of genomics in health care are described, for the benefit of individual patients and populations worldwide.