bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismoelectric wave conversions at an interface: a quantitative comparison between laboratory data and full-waveform modelling
Authors: Martins-Gomes V , Brito D , Garambois S , Dietrich M , Bordes C , Barucq H 
Published: October 2023

SUMMARYSeismo-electromagnetic phenomena, electrokinetic in nature, take place whenever a seismic wave propagates in fluid-bearing media, its energy depending mainly on the electrical properties of the fluid and the hydraulic properties of the porous medium. They result from a conversion of mechanical into electromagnetic (EM) energy due to the transient ionic interactions occurring at the pore scale. Two of these phenomena are usually studied: the electric field accompanying seismic waves, and the EM field that travels independently, generated at discontinuities of physicochemical properties in the porous medium. Although the first event is sensitive to physical parameters of the surrounding medium, the second catches information about interfaces in the subsurface, with the resolution of seismic methods, making it very attractive to near surface exploration. In this context, we propose a new experimental setup where both phenomena can be simultaneously studied. At first, we use a porous medium composed of homogeneous water-saturated sand and study the characteristics of the coseismic electric field. Afterwards, a thin layer of Vosges sandstone is inserted into the sand, which allows the study of the EM waves generated at the two closely spaced sand-sandstone interfaces. We record the seismic displacement field at the upper surface of the sand volume using a laser vibrometer, and use stainless steel electrodes buried in the sand to acquire individual electric potentials rather than electric fields, seeking to favour the measurement of the EM interface-generated signals. With the help of direct numerical simulations, we compare experimental measurements and theoretical predictions, based on a well established set of seismoelectric governing equations. In both types of experiments, this comparison shows very good agreements between experimental and numerical waveforms, thus confirming the relevant theory. The electric potential data also show that the EM signals generated at interfaces are clearly recorded at distances of about 10 seismic P wavelengths away from the interface. By contrast, the same events are barely noticeable near the inserted layer when measured using classical electric dipolar arrays.
Exploiting O-GlcNAc transferase promiscuity to dissect site-specific O-GlcNAcylation
Authors: Mitchell Conor W , Galan Bartual Sergio , Ferenbach Andrew T , Scavenius Carsten , van Aalten Daan M F 
Published: October 2023

Abstract
Protein O-GlcNAcylation is an evolutionary conserved post-translational modification catalysed by the nucleocytoplasmic O-GlcNAc transferase (OGT) and reversed by O-GlcNAcase (OGA). How site-specific O-GlcNAcylation modulates a diverse range of cellular processes is largely unknown. A limiting factor in studying this is the lack of accessible techniques capable of producing homogeneously O-GlcNAcylated proteins, in high yield, for in vitro studies. Here, we exploit the tolerance of OGT for cysteine instead of serine, combined with a co-expressed OGA to achieve site-specific, highly homogeneous mono-glycosylation. Applying this to DDX3X, TAB1, and CK2α, we demonstrate that near-homogeneous mono-S-GlcNAcylation of these proteins promotes DDX3X and CK2α solubility and enables production of mono-S-GlcNAcylated TAB1 crystals, albeit with limited diffraction. Taken together, this work provides a new approach for functional dissection of protein O-GlcNAcylation.
Effects of social comparison framing of racial health disparities and behaviors
Authors: Liu Jiawei , Niederdeppe Jeff 
Published: October 2023

Abstract
Messages that feature intergroup comparisons (social comparison frames) regularly communicate the relative prevalence of health problems and preventive behaviors. While prior studies find that comparing disease risks between racial groups are met with resistance from the disadvantaged group, we extended existing research by investigating if behavioral comparisons which show that the higher-risk group also excels in disease prevention efforts could mitigate negative impacts of disease risk comparisons. We conducted two preregistered experiments to examine the effects of comparing cancer risks and the prevalence of screening behaviors between Black and White Americans. Communicating racial disparities in breast cancer mortality reduced perceived risks and fear among White Americans (the less-at-risk group) and decreased cancer screening intention among Black Americans (the disadvantaged group). Adding cancer screening prevalence comparisons did not shift screening intentions among Black Americans but changed their support for disparity-reducing policies, though the effects depended on the disease in question.
Plasma Extracellular Vesicle LncRNA H19 as a Potential Diagnostic Biomarker for Inflammatory Bowel Diseases
Authors: Heydari Raheleh , Fayazzadeh Sara , Shahrokh Shabnam , Shekari Faezeh , Farsad Faraneh , Meyfour Anna 
Published: October 2023

Abstract

Background
Inflammatory bowel disease (IBD) is a complex gastrointestinal disease with 2 main subtypes of Crohn’s disease (CD) and ulcerative colitis (UC), whose diagnosis mainly depends on the medical history, clinical symptoms, endoscopic, histologic, radiological, and serological findings. Extracellular vesicles (EVs) are now considered an additional mechanism for intercellular communication, allowing cells to exchange biomolecules. Long noncoding RNAs (lncRNAs) that are enriched in EVs have been defined as an ideal diagnostic biomarker for diseases. In this study, we investigated the expression differences of 5 lncRNAs in tissue and plasma EVs of active IBD patients compared with patients in the remission phase and healthy controls to introduce an EV-lncRNA as a noninvasive IBD diagnostic biomarker.

Methods
Twenty-two active IBD patients, 14 patients in the remission phase, 10 active rheumatoid arthritis (RA) patients, 14 irritable bowel syndrome (IBS) patients, and 22 healthy individuals were recruited in the discovery cohort. In addition, 16 patients with active IBD, 16 healthy controls, 10 inactive IBD patients, 12 active RA patients, and 14 IBS patients were also included in the validation cohort. The expression levels of 5 lncRNAs in tissue and EV-plasma were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) . Machine learning and receiver operating characteristic (ROC) curve analysis were performed to investigate the distinguishing ability of the candidate biomarkers.

Results
While the expression levels of lncRNAs CDKN2B-AS1, GAS5, and TUG1 were significantly downregulated, lncRNAs H19 and CRNDE were overexpressed in active IBD lesions. Expression of H19 was detected in plasma EVs whose isolation had been confirmed via dynamic light scattering, microscopy images, and western blotting. The classification results demonstrated the excellent ability of H19 in distinguishing IBD/active from IBD/remission, healthy control, RA, and IBS (area under the ROC curve = 0.95, 0.97,1, and 0.97 respectively).

Conclusions
Our study suggests that circulating EV-lncRNA H19 exhibited promising potential for the diagnosis of active IBD.
Countrywide analysis of heat- and cold-related mortality trends in the Czech Republic: growing inequalities under recent climate warming
Authors: Janoš Tomáš , Ballester Joan , Čupr Pavel , Achebak Hicham 
Published: October 2023

Abstract

Background
Only little is known about trends in temperature–mortality associations among the most vulnerable subgroups, especially in the areas of central and eastern Europe, which are considered major climatic hotspots in terms of heatwave exposure. Thus, we aimed to assess trends in temperature-related mortality in the Czech Republic by sex, age and cause of death, and to quantify the temporal evolution of possible inequalities.

Methods
We collected daily time series of all-cause (1987–2019) and cause-specific (1994–2019) mortality by sex and age category, and population-weighted daily mean 2-metre temperatures for each region of the Czech Republic. We applied a quasi-Poisson regression model to estimate the trends in region-specific temperature–mortality associations, with distributed lag non-linear models and multivariate random-effects meta-analysis to derive average associations across the country. We then calculated mortality attributable to non-optimal temperatures and implemented the indicator of sex- and age-dependent inequalities.

Results
We observed a similar risk of mortality due to cold temperatures for men and women. Conversely, for warm temperatures, a higher risk was observed for women. Results by age showed a clear pattern of increasing risk due to non-optimum temperatures with increasing age category. The relative risk (RR) related to cold was considerably attenuated in most of the studied subgroups during the study period, whereas an increase in the RR associated with heat was seen in the overall population, in women, in the age category 90+ years and with respect to respiratory causes. Moreover, underlying sex- and age-dependent inequalities experienced substantial growth.

Conclusions
Our findings suggest ongoing adaptation to cold temperatures. Mal/adaptation to hot temperatures occurred unequally among population subgroups and resulted in growing inequalities between the sexes and among age categories.
Neonatal pain management practice in the neonatal intensive care unit of public hospitals: a survey of healthcare providers in eastern Ethiopia
Authors: Kebede Sinetibeb Mesfin , Degefa Meron , Getachew Tamirat , Lami Magarsa , Tadesse Barkot , Bekele Habtamu 
Published: October 2023

Abstract

Background
Newborns experience multiple painful and stressful procedures during their hospitalization in neonatal intensive care units (NICUs). Repeated or untreated pain can have negative consequences for the health and development of newborns. Despite the growing knowledge of pain assessment and intervention, several studies have shown that the practice of neonatal pain management among healthcare providers is poor. Therefore, data regarding neonatal pain management practice and affecting factors are essential for taking appropriate actions. This study assessed neonatal pain management practice and associated factors among healthcare providers working in the NICUs of public hospitals in eastern Ethiopia from 1 January to 28 February 2022.

Methods
An institution-based cross-sectional study design was used among 372 randomly selected healthcare providers working in the NICUs of public hospitals in eastern Ethiopia. Data were collected using a pre-tested structured self-administered questionnaire and an observation checklist. The collected data were reviewed, coded and entered into Epi-data version 3.1 and exported to SPSS version 25 for analysis. Bivariate and multivariable logistic regression were used to identify the associations between outcome and predictor variables at a 95% confidence level and P-values &lt;0.05 were considered statistically significant.

Results
The study found that 185 (53.9%; 95% confidence interval [CI] 48.4 to 59.2) of the 343 respondents had good neonatal pain management practice with a mean of 11.38 (standard deviation 3.64). Receipt of in-service training in neonatal pain management (adjusted odds ratio [AOR] 2.12 [95% CI 1.15 to 3.91]), availability of protocols and guidelines in the NICUs (AOR 2.94 [95% CI 1.74 to 4.91]) and accessibility of analgesics in the NICUs (AOR 4.302 [95% CI 2.46 to 7.53]) were significantly associated with good neonatal pain management practice.

Conclusions
The overall practice of healthcare providers in neonatal pain management in public hospitals in eastern Ethiopia is relatively high compared with previous studies conducted in Ethiopia. Improving the availability of analgesics as well as neonatal pain management protocols and guidelines in NICUs will aid in the promotion of good neonatal pain management practices. In addition, providing ongoing in-service training on neonatal pain management will allow healthcare providers to better care for newborns in pain.
New insights into peroxide toxicology: sporulenes help Bacillus subtilis endospores from hydrogen peroxide
Authors: Smita N , Sasikala Ch , Ramana ChV 
Published: October 2023

Abstract

Aim
The purpose of the present study was to understand the possible events involved in the toxicity of hydrogen peroxide (H2O2) to wild and sporulene-deficient spores of Bacillus subtilis, as H2O2 was previously shown to have deleterious effects.

Methods and results
The investigation utilized two strains of B. subtilis, namely the wild-type PY79 (WT) and the sporulene-deficient TB10 (ΔsqhC mutant). Following treatment with 0.05% H2O2 (v/v), spore viability was assessed using a plate count assay, which revealed a significant decrease in cultivability of 80% for the ΔsqhC mutant spores. Possible reasons for the loss of spore viability were investigated with microscopic analysis, dipicholinic acid (DPA) quantification and propidium iodide (PI) staining. Microscopic examinations revealed the presence of withered and deflated morphologies in spores of ΔsqhC mutants treated with H2O2, indicating a compromised membrane permeability. This was further substantiated by the absence of DPA and a high frequency (50%–75%) of PI infiltration. The results of fatty acid methyl ester analysis and protein profiling indicated that the potentiation of H2O2-induced cellular responses was manifested in the form of altered spore composition in ΔsqhC B. subtilis. The slowed growth rates of the ΔsqhC mutant and the heightened sporulene biosynthesis pathways in the WT strain, both upon exposure to H2O2, suggested a protective function for sporulenes in vegetative cells.

Conclusions
Sporulenes serve as a protective layer for the inner membrane of spores, thus assuming a significant role in mitigating the adverse effects of H2O2 in WT B. subtilis. The toxic effects of H2O2 were even more pronounced in the spores of the ΔsqhC mutant, which lacks this protective barrier of sporulenes.
Large-scale affordable housing construction and public goods provision: evidence from Iran
Authors: Tajrishy Saeed , Vesal Mohammad 
Published: October 2023

Abstract
Affordable housing projects may affect neighboring property values. Negative spillovers are more likely in developing countries because governments may fail to provide complementary infrastructures such as schools. We study one of the world’s largest affordable housing projects, the Mehr housing project in Iran, which facilitated the construction of 2 million affordable apartments. Using the universe of house transactions in nineteen large cities, we employ a difference-in-differences methodology to estimate the causal impact of Mehr on neighboring properties. Results show nearby housing prices fall by 11%. This negative effect fades away in neighborhoods that saw a proportionate expansion of schools.
Crosswell frequency-domain reverse time migration imaging with wavefield decomposition
Authors: Yang Jixin , He Xiao , Chen Hao 
Published: October 2023

Abstract
Crosswell seismic technique can provide high-resolution imaging and monitoring of the subsurface. However, compared to the surface seismic, crosswell data contain more complex wave components, which increases the difficulty of seismic processing and migrations. Conventional acoustic reverse time migration (RTM) mainly uses the cross-correlation of the source forward and the receiver backward wavefields. The redundant information generated by cross-correlation may undermine the imaging reliability in the crosswell models. Thus, we develop a novel wavefield decomposition imaging condition and only used cross-correlation information of incident and reflection waves in the same propagation directions, which eliminates the artifacts generated from the cross-correlation of wave information unrelated to reflections in the crosswell image. We perform RTM in the frequency domain to maintain efficiency in multi-shot problems. A mono-frequency wavefield decomposition method is applied to separate and process the seismic data. The forward and backward wavefields are reclassified into the up- and downpropagating components. The L1 norm is introduced to enhance the robustness of the proposed imaging method. We then use this method to synthesize data from layering models and analyze the imaging results generated from each pair of cross-correlations using source and receiver wavefields. Results show that the cross-correlation information belonging to the same propagation contributes most to the crosswell image, and the other information always generates migration noises. Moreover, we apply the proposed method to a real-field dataset. Processing results validate the effectiveness of the proposed means for eliminating false events in the crosswell models and improving image quality.
NAC transcription factor SlNOR-like1 plays a dual regulatory role in tomato fruit cuticle formation
Authors: Liu Gang-Shuai , Huang Hua , Grierson Donald , Gao Ying , Ji Xiang , Peng Zhen-Zhen , Li Hong-Li , Niu Xiao-Lin , Jia Wen , He Jian-Lin , Xiang Lan-Ting , Gao Hai-Yan , Qu Gui-Qin , Zhu Hong-Liang , Zhu Ben-Zhong , Luo Yun-Bo , Fu Da-Qi 
Published: October 2023

Abstract
The plant cuticle is an important protective barrier on the plant surface, constructed mainly by polymerized cutin matrix and a complex wax mixture. Although the pathway of plant cuticle biosynthesis has been clarified, knowledge of the transcriptional regulation network underlying fruit cuticle formation remains limited. In the present work, we discovered that tomato fruits of the NAC transcription factor SlNOR-like1 knockout mutants (nor-like1) produced by CRISPR/Cas9 [clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9] displayed reduced cutin deposition and cuticle thickness, with a microcracking phenotype, while wax accumulation was promoted. Further research revealed that SlNOR-like1 promotes cutin deposition by binding to the promoters of glycerol-3-phosphate acyltransferase6 (SlGPAT6; a key gene for cutin monomer formation) and CUTIN DEFICIENT2 (SlCD2; a positive regulator of cutin production) to activate their expression. Meanwhile, SlNOR-like1 inhibits wax accumulation, acting as a transcriptional repressor by targeting wax biosynthesis, and transport-related genes 3-ketoacyl-CoA synthase1 (SlKCS1), ECERIFERUM 1-2 (SlCER1-2), SlWAX2, and glycosylphosphatidylinositol-anchored lipid transfer protein 1-like (SlLTPG1-like). In conclusion, SlNOR-like1 executes a dual regulatory effect on tomato fruit cuticle development. Our results provide a new model for the transcriptional regulation of fruit cuticle formation.
Combining reproducibility and repeatability studies with applications in forensic science
Authors: Arora Hina , Kaplan-Damary Naomi , Stern Hal S 
Published: October 2023

Abstract
Studying the repeatability and reproducibility of decisions made during forensic examinations is important in order to better understand variation in decisions and establish confidence in procedures. For disciplines that rely on comparisons made by trained examiners such as for latent prints, handwriting, and cartridge cases, it has been recommended that ‘black-box’ studies be used to estimate the reliability and validity of decisions. In a typical black-box study, examiners are asked to judge samples of evidence as they would in practice, and their decisions are recorded; the ground truth about samples is known by the study designers. The design for such studies includes repeated assessments on forensic samples by different examiners and additionally, it is common for a subset of examiners to provide repeated assessments on the same evidence samples. We demonstrate a statistical approach to analyse the data collected across these repeated trials that offers the following advantages: i) we can make joint inference about repeatability and reproducibility while utilizing both the intra-examiner and inter-examiner data, ii) we can account for examiner–sample interactions that may impact the decision-making process. We demonstrate the approach first for continuous outcomes such as where decisions are made on an ordinal scale with many categories. The approach is next applied to binary decisions and results are presented on the data from two black-box studies.
Nested spheroidal figures of equilibrium − IV. On heterogeneous configurations
Authors: Staelen C , Huré J-M 
Published: October 2023

ABSTRACT
The theory of nested figures of equilibrium, expanded in Papers I and II, is investigated in the limit where the number of layers of the rotating body is infinite, enabling to reach full heterogeneity. In the asymptotic process, the discrete set of equations becomes a differential equation for the rotation rate. In the special case of rigid rotation (from centre to surface), we are led to an integro-differential equation (IDE) linking the ellipticity of isopycnic surfaces to the equatorial mass-density profile. In contrast with most studies, these equations are not restricted to small flattenings, but are valid for fast rotators as well. We use numerical solutions obtained from the self-consistent-field method to validate this approach. At small ellipticities (slow rotation), we fully recover Clairaut’s equation. Comparisons with Chandrasekhar’s perturbative approach and with Roberts’ work based on virial equations are successful. We derive a criterion to characterize the transition from slow to fast rotators. The treatment of heterogeneous structures containing mass-density jumps is proposed through a modified IDE.
Multiband optical variability on diverse time-scales of the TeV blazar TXS 0506 + 056, the first cosmic neutrino source
Authors: Dhiman Vinit , Gupta Alok C , Bachev Rumen , Wiita Paul J , Cellone Sergio A , Strigachev A , Gaur Haritma , Darriba A , Bisen D P , Locatelli G , Mammana L A , Semkov E 
Published: October 2023

ABSTRACT
We report the first extensive optical flux and spectral variability study of the TeV blazar TXS 0506 + 056 on intranight to long-term time-scales using BVRI data collected over 220 nights between 2017 January 21 to 2022 April 9 using eight optical ground-based telescopes. In our search for intraday variability (IDV), we have employed two statistical analysis techniques, the nested ANOVA test and the power enhanced F-test. We found the source was variable in 8 nights out of 35 in the R-band and in 2 of 14 in the V-band yielding duty cycles (DC) of 22.8 per cent and 14.3 per cent, respectively. Clear colour variation in V − R was seen in only 1 out of 14 observing nights, but no IDV was found in the more limited B, I, and B − I data. During our monitoring period the source showed a 1.18 mag variation in the R-band and similar variations are clearly seen at all optical wavelengths. We extracted the optical (BVRI) SEDs of the blazar for 44 nights when observations were carried out in all four of those wavebands. The mean spectral index (α) was determined to be 0.897 ± 0.171.