bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scientific Analysis of Two Compound Eye Beads Unearthed in Hejia Village, Zhouling
Authors: Li Jingyu , Sun Feng , Ha Wenhui , Zhai Haihong , Zhai Congwen 
Published: October 2023

Abstract

Glass compound eye beads is the exquisite embodiment of the glass making technology of ancient craftsmen, and is a example of the cultural exchange between China and the West in the Warring States Period. In the existing scientific research of compound eye beads, only the chemical element composition and fabtication process are discussed, and the weathering mechanism of this kind of objects are rarely discussed. In this study, two dots & mesh beads with seriously weathered surfaces were unearthed in Hejia village, Zhouling. Micromorphology, X-ray fluorescence spectroscopy (XRF) and microscopic laser Raman spectroscopy were used for non-destructive testing to analyze them. The results show that the two compound eye beads belong to the lead-barium silicate system. The substrate of the beads is glassy, the yellow weathered layer in is cerussite, the white weathered layer is barium sulfate and the blue weathered layer is walstromite. It is the first time that the walstromite has been found in the weathered layer of ancient glass. This study focused on the analysis of weathered layers of two compound eye beads, and inferred about their weathering mechanism. In order to provide data support for the subsequent protection of glass compound eye beads, it has certain scientific value.
Evaluation of Atrial Electromechanical Conduction Times and P- Wave Indices and Parameters in Children with Type-1 Diabetes Mellitus
Authors: Özde Şükriye , Aktüre Gülşah , Yavuzyılmaz Fatma , Arslanoğlu İlknur , Özde Cem , Kayapınar Osman , Kaya Adnan , Coşkun Gökhan , Sayın Ahmet Egemen 
Published: October 2023

Abstract
The aim of the study was to investigate the presence of signs of atrial cardiomyopathy, which is thought to be the main underlying cause of the physiopathology of atrial fibrillation (AF) in children with type 1 diabetes mellitus (T1DM). The study analysed echocardiographic atrial electromechanical conduction times (AEMct), P-terminal force in lead V1 (PTFV1), an electrocardiographic index not previously evaluated in the paediatric population, and a selection of P-wave parameters (P-WPs). This was a cross-sectional, observational study involving 105 children diagnosed with T1DM and 101 healthy children with comparable characteristics. P-WPs were evaluated through electrocardiography, and AEMct were assessed using echocardiography in each patient. A statistical comparison was made of all resultant data. PTFV1, P-wave dispersion (P-Wdi) and electrocardiogram time from P-wave onset to lateral mitral annular late diastolic peak velocity (PA-lateral) in the diabetes group, both in the univariate model (0.99 ± 0.90 vs 3.32 ± 2.36, p < 0.000; 75.4 ± 10.9 vs 79.1 ± 11. 2 p = 0.022; and 24.7 ± 11.6 vs 48.2 ± 14.4 p < 0.000; respectively) and in the multivariate model (Exp(B)/OR: 3.928, 95% CI: 2.339–6.596, p < 0. 001; Exp(B)/OR: 1.171, 95% CI: 1.109–1.236, p < 0.001; and Exp(B)/OR: 1.660, 95% CI: 1.265–1.236, p < 0.001; respectively) were significantly higher. A weak but statistically significant positive correlation was found between the mean HgA1c level and both P-Wdi (r = 0.204, p = 0.037) and inter-atrial electromechanical delay (r = 0.207, p = 0.044). The electrical deterioration of the atria may begin subclinically at a very early stage of T1DM that begins in childhood, even though the atria appear structurally normal. The results of this study indicate that T1DM in childhood could potentially be linked to an amplified threat of AF development.
The Effect of Blood Purification Combined with Psychological Care on Children with Amanita Phalloides Poisoning: A Retrospective Study
Authors: Yang Meng , Zong Yixuan , Zhu Guangfen , Cheng Xuejin , Liu Yunna , Zi Minxue , Su Xuan , Zhang Fan , Liu Kai , Zhang Lifang 
Published: October 2023

Abstract

Background: Amanita phalloides poisoning is a life-threatening condition that can cause acute liver failure, coagulopathy, and multi-organ failure. Blood purification treatment and nursing care are essential for managing this poisoning. However, there is a lack of systematic comparison of the effects of different blood purification methods and nursing techniques on the prognosis and quality of life of patients with Amanita phalloides poisoning.
Methods: We conducted a retrospective observational study of 43 patients with Amanita phalloides poisoning who were admitted to the PICU of a tertiary hospital from January 2019 to December 2021. We collected and analyzed their demographic and biochemical data, blood purification treatment, nursing method, and outcome. We also assessed the psychological state and quality of life of 3-year-old children using the Child Behavior Checklist (CBCL) before and after treatment.
Results: Blood purification treatment significantly improved the biochemical indicators and patient outcomes. Intensive and psychological care assistance reduced the average recovery time and increased the proportion of improved patients. Psychological care assistance also improved the psychological state of 3-year-old children. No significant differences in biochemical indicators existed between male and female patients before treatment. Prothrombin time and blood ammonia levels varied significantly by age before treatment.
Conclusions: Our study suggests that blood purification treatment effectively removes toxins and improves liver function and coagulation status in patients with Amanita phalloides poisoning. Intensive care and psychological care assistance can enhance the physical and mental health of the patients and promote their recovery. We recommend a comprehensive treatment and nursing program to improve patients' prognosis and quality of life with Amanita phalloides poisoning.
Network Attack Knowledge Reasoning Model based on Graph Convolutional Neural Networks
Authors: Ren WeiWu , Lei Ying , Hong Yu , Song XinTong , Yao JinYu , Du YaZhou , Li WenJuan 
Published: October 2023

Abstract
To address the challenge of analyzing large-scale penetration attacks involving complex multiple relations and multi-hop pathways, we have proposed an attack knowledge inference model based on graph convolutional neural networks. The core concept of this model involves obtaining knowledge embeddings related to CVE, CWE, and CAPEC to construct attack context feature data and relationship matrices. Subsequently, we utilize a graph convolutional neural network model for attack classification and employ the CONVE model for attack inference within the same attack category. Research results have shown that this approach outperforms other inference methods in terms of both inference accuracy and efficiency. Through improvements to the graph convolutional neural network model, we have significantly enhanced the accuracy and generalization capability of the attack classification task. Furthermore, we have introduced the use of the CONVE model for attack inference tasks for the first time, and experimental results demonstrate that the CONVE model can infer implicit relationships between CVE-CVE, CVE-CWE, and CVE-CAPEC. This method allows for a deeper learning and understanding of entity relationships within the attack knowledge graph and even aids in revealing certain hidden connections.
Short-term extinction predicted by population viability analysis for a Neotropical salt marsh endemic bird
Authors: Sandretti-Silva Giovanna , Vannucchi Fabio Stucchi , Teixeira Larissa , Yeuw Tan Tjui , Mori Gustavo Maruyama , Reinert Bianca Luiza , Bornschein Marcos Ricardo 
Published: October 2023

Abstract

Salt marshes pose challenges for the birds that inhabit them, including high rates of nest flooding, tipping, and predation. The impacts of rising sea levels and invasive species further exacerbate these challenges. To assess the urgency of conservation and adequacy of new actions, researchers and wildlife managers may use population viability analyses (PVAs) to identify population trends and major threats. We conducted PVA for Formicivora acutirostris, which is a threatened neotropical bird species endemic to salt marshes. We studied the species’ demography in different sectors of an estuary in southern Brazil from 2006–2023 and estimated the sex ratio, longevity, productivity, first-year survival, and mortality rates. For a 133-year period, starting in 1990, we modeled four scenarios: 1) pessimistic and 2) optimistic scenarios, including the worst and best values for the parameters; 3) a baseline scenario, with intermediate values; and 4) scenarios under conservation management, with increased recruitment and/or habitat preservation. Projections indicated population decline for all assessment scenarios, with a 100% probability of extinction within 34 years in the pessimistic scenario and no extinction in the optimistic scenario. The conservation scenarios indicated population stability with 16% improvement in productivity, 10% improvement in first-year survival, and stable carrying capacity. The disjunct distribution of the species, with remnants concentrated in a broad interface with arboreal habitats, may seal the population decline by increasing nest predation. The species should be considered conservation dependent, and we recommend assisted colonization, predator control, habitat recovery, and ex situ conservation.
Equality, Diversity and Inclusion: A Case for Public Procurement Bid Disputes Management In Kenya
Authors: Nyathore Paul Mathenge , Wainaina Gituro , Awino Zachary Bolo , Kariuki James Thuo 
Published: October 2023

Abstract
The United Nations Sustainable Development Goals (SDGs) advocate for equality, diversity and inclusion. The SDG 5 promote gender equality while SDG 10 advocate for reduced inequalities. Public procurement has grown to become a critical means of helping governments achieve political, economic, social, technological, environmental, and even legal policy objectives. The objective of this paper was to assess equality, diversity and inclusion in management of bid disputes in Kenya. Content analysis of all the bid dispute cases heard and determined by Public Procurement Administrative Review Board (PPARB) between 2011 and 2020 was conducted. In addition, request for review procedures and guiding laws were also reviewed. Analysis of descriptive data supported by deductive reasoning was thereafter conducted. It was established that request for review filing procedures in Kenya do not favour would be applicants especially those falling in the categories of youth, women, people living with disabilities and MSMEs. The paper has made contribution to body of knowledge regarding management of public procurement bid disputes in Kenya. The paper recommended that policy review be initiated to promote equality, diversity and inclusion in management of bid disputes.
The combination of elesclomol and Cu2+ can inhibit the growth of colon cancer cells by targeting FDX1
Authors: Yu Jing , Peng Yuanhong , Wang Kang , Xu Qihuan , Li Haibin , Lu Yan , Ouyang Manzhao 
Published: October 2023

Abstract

Background
Colon adenocarcinoma (COAD) is the predominant histological type of colon cancer. Elesclomol, a unique copper ion carrier, is considered a potential anticancer drug and has been the subject of a series of clinical trials. FDX1 is the intended target of elesclomol and is believed to be a key regulatory factor in copper-mediated cell death. Through its specific targeting of FDX1, ES-Cu can lead to a reduction in Fe-S stability, potentially enabling more precise tumor destruction. However, further research is still needed regarding the use of elesclomol in the treatment of colon adenocarcinoma.
Methods
Through bioinformatics analysis, this study aims to explore the molecular expression, clinical relevance, and prognostic significance of FDX1 in COAD Additionally, based on in vitro and in vivo experiments, the therapeutic value of elesclomol in the treatment of colon adenocarcinoma will be investigated.
Result
The expression of FDX1 is significantly different between COAD and normal tissues. Patients with high expression of FDX1 tend to have better prognosis compared to those with low expression. FDX1 shows high sensitivity and specificity in diagnosing colon cancer. Immunohistochemical analysis suggests a strong correlation between FDX1 and various immune cells and immune checkpoints. TIDE scoring also indicates that patients with high FDX1 expression levels are more responsive to immune therapy. Furthermore, both in vitro and in vivo experiments have demonstrated that the combination of elesclomol and Cu2 + efficiently inhibits the growth of colon cancer cells, and the safety profile of this treatment approach is acceptable. Lastly, real-time quantitative PCR (qRT-PCR) experiments on colon cancer cell lines and animal tumor models have shown that elesclomol upregulates the expression level of FDX1.
Conclusion
The combination of elesclomol and Cu2 + can inhibit the growth of colon cancer cells by targeting FDX1.
Investigation of geomagnetic field variations in search of seismo-electromagnetic emissions associated with earthquakes in subduction zone of Andaman-Nicobar, India
Authors: Prajapati Rahul , Arora Kusumita 
Published: October 2023

Abstract

The study of seismo-electromagnetic emissions has the potential to provide new insights into the physics of seismic activity and improve our ability to monitor and predict earthquakes and other geophysical events. In this study, we examine one year of ground based geomagnetic data during March-2019 to April − 2020 from the Andaman subduction zone for signatures related to lithospheric processes. We focus on anomalous signatures in the vertical component of geomagnetic field after removing the global and seasonal effect from the data. We have also scanned for corresponding signatures in the polarization ratios estimated from spectral density in ULF range. Over the duration of one year, we noted an 80% enhancement in polarisation ratios and 67% deviations in diurnal ratios average 18 days before of earthquake events. Apart this, the significant enhances in diurnal and polarization ratio are successfully correlated with 11 out of 14 earthquakes shows an approximately 78 percent success ratio of present study.
Characteristics of Pseudophakic Retinal Detachment and Risk Factors of Recurrence
Authors: Gibelalde Ane , Pinar-Sueiro Sergio , Ibarrondo Oliver , Miguel Miguel Ruiz , Martínez-Soroa Itziar , Mendicute Javier 
Published: October 2023

Abstract

Background: The present study was designed to gain knowledge about the prognostic factors and evolution of pseudophakic retinal detachment (PRD) and to analyse the main characteristics of PRD, such as the mean time to retinal detachment following cataract surgery, as well as the clinical factors associated with the risk of recurrence and worse anatomical and functional outcomes.
Methods:This was a retrospective monocentric study of 330 patients with PRD who underwent surgery between 2012 and 2020.
All patients were pseudophakic andwere referred for retinal detachment surgery at Donostia University Hospital (Terciary Hospital, Spain).
Results: The mean age of the patients at the time of phacoemulsification was 63.06 ± 10.8 years, and 49.09% of them had moderate myopia [axial length (AL) (23.5-26.5 mm)]. In our series, macular detachment was evident in 69.09% (n=228) of the patients. The mean time that elapsed between phacoemulsification and PRD surgery was 4.04 ± 4.17 years, which was reduced by half in the event of surgical complications (2.24 ± 2.65). The rate of PRD was 28.79%. The anatomical results in terms of retinal reapplication were better with the combination of vitrectomy and scleral buckling (83.1% vs. 70.5%) (p=0,127) compared with vitrectomy. The variables associated with a higher risk of recurrence were male sex (hazardratio (HR)= 1.75), macular detachment (HR= 2.00) and the presence of proliferative vitreoretinopathy (PVR) (HR= 3.21).
Conclusions: PRD usually occurs within 4 years of phacoemulsification, although it may occur significantly earlier in the event of surgical complications. Macular involvement, PVR, and male sex are all associated with a higher risk of PRD recurrence.
Seedling responses to herbivory are driven by nutrient enrichment, grass competition and functional attributes
Authors: Bhadouria Rahul , Singh Rishikesh , Krishna Mayank , Tripathi Sachchidanand , Srivast Pratap , Raghubanshi Akhilesh Singh 
Published: October 2023

Abstract

The factors that affect the establishment and growth of tree seedlings include herbivory and competition for nutrients from the indigenous grasses. Grazers and browsers alter the dynamics of tree seedling establishment by directly devouring plant tissue, altering soil nutrient status (through fertilisation and trampling), and competing with grasses. Additionally, seedlings of the tree species with contrasting successional status and functional attributes may respond differently to these factors. In this study, we assessed the effects of different levels of soil nutrient availability, defoliation (mimicking herbivory), and grass competition on the seedlings of the four plant species with contrasting functional traits (N2-fixers versus non-N2-Fixers) and addressed whether there is any difference in the responses of individual species in terms of growth parameters (height, basal area, seedling biomass, relative growth rate), and leaf nutrient concentration. We observed that the defoliation significantly reduced the seedling survival. In the presence of grass, N2-fixing species fared better than non-N2 fixture species in terms of survival, which suggests that grass's competition for nutrients might lead to an increase in nodulation in N2-fixing species. Further, defoliated seedlings were able to increase their chances of survival when nutrient was supplemented. However, this effect was not observed when they were competing with grass for nutrients. The impact of defoliation was observed only for seedling height which reduced significantly; girth and dry weight were not found significantly different. Results of the study suggest that dry tropical seedlings are adapted to defoliation as they recover leaf function by increasing leaf number, leaf area, and leaf nutrients as well as stimulating compensatory branching. Higher relative growth response for height under nutrient addition and grass competition revealed that seedlings are taking advantage of nutrient supplements along with grass. Leaf N concentration was higher in N2 fixture species as compared to non-N2 fixture species. Although longer-term studies are needed to investigate the impacts of defoliation, nutrients, and grass competition, our findings give valuable information that can assist in the design of strategies for the restoration of India's dry tropical forests.
Managing hepatocellular carcinoma (HCC) across the stages: Efficacy and outcomes of stereotactic body radiotherapy (SBRT), a retrospective study
Authors: Mohamed Ahmed Allam , Berres Marie-Luise , Bruners Philipp , Lang Sven Arke , Trautwein Christian , Wiltberger Georg , Barabasch Alexandera , Eble Michael 
Published: October 2023

Abstract

Purpose:
Hepatocellular carcinoma (HCC) poses a unique challenge due to its predilection for developing a compromised liver, often limiting surgical options. Stereotactic body radiotherapy (SBRT) has emerged as a promising local treatment modality for HCC. This study aims to assess the effectiveness of SBRT in HCC patients unsuitable for surgery, focusing on local control, optimal radiation dosing, and prognostic factors.
Methods:
In this retrospective analysis, 52 HCC patients treated with SBRT were examined. The study assessed local control, progression-free survival (PFS), and overall survival (OS) while conducting dosimetric analyses. The relationship between mean liver dose and Child-Pugh Score (CPS) progression was also explored.
Results:
SBRT demonstrated a remarkable 95.7% freedom from local progression (FFLP) at 12 months. Notably, a D98% below 61 Gy (EQD2 α/ β 10) was associated with reduced FFLP (p-value 0.055). Logistic regression analysis revealed a dose-response relationship, with a 98% probability of tumor control at a prescribed radiation dose of 73.1 Gy. The study observed OS rates of 63.9% at one year and 32.8% at three years. Patients with portal vein tumor thrombus (PVTT) and larger tumors (≥ 37 cm³) experienced decreased PFS and OS. Multivariate analysis identified PVTT, larger tumor volume, and performance status as independent predictors of reduced OS. Notably, c-RILD was absent, but ncRILD occurred in 7.7% of patients. Regression analysis linked a mean EQD2 α/ β 3 dose to the liver with a 10% likelihood of ncRILD.
Conclusion:
SBRT offers a compelling option for achieving high local control and promising survival outcomes in HCC. The study supports a radiation dose range of 61-73.1 Gy, coupled with a mean liver dose under 12.6 Gy as EQD2, to achieve favorable FFLP rates with acceptable toxicity rates.
Chocó: aventura gastronómica y joya turística del Pacífico colombiano
Authors: Gómez Rodríguez Lida Mariam , Nariño Bernal Viviana 
Published: October 2023

Este documento presenta la caracterización de ingredientes, tradiciones y técnicas culinarias propias de Nuquí (municipio), El Valle, Arusí, Panguí y Coquí (corregimientos) del departamento del Chocó (Colombia) que limita con el Océano Pacífico. Región privilegiada ya que cuenta con selva, ríos, manglares y mar, ecosistemas que proveen a sus habitantes diversidad de ingredientes convirtiendo a esta zona apartada en un destino gastronómico y de ecoturismo no solo por sus bellos paisajes sino además por la práctica de avistamiento de ballenas en los meses de julio a octubre. El estudio es de enfoque cualitativo con alcance descriptivo, diseño no experimental, muestreo no probabilístico. Se realizaron entrevistas a cocineras de tradición, en las que se caracterizaron 9 hierbas de azotea, 15 frutas, 4 variedades de plátanos, 8 pescados – mariscos y 4 productos de origen vegetal empleados como contenedores, envoltorios de alimentos y especias.
Bioethical issues related to the principle of utility in the residential consumption of drinking water in Colombia
Authors: Rodríguez Zambrano Hernando , Díaz Rodríguez Carlos 
Published: October 2023

Abstract

This research seeks to investigate bioethical issues related to the principle of utility in the residential consumption of drinking water in Colombia. The analysis is carried out using the hermeneutic analysis method. The research highlights the influence of the tariff policies implemented between 1994 and 2021, which have depended on the management of the Government, the efficiency of water supply companies, and the freedom of decision-making. The results show, among others, that: the tariff policy has rationalized basic water consumption in vulnerable populations, but with a clear regressive trend; the principle of utility prioritizes financial sufficiency over considerations of efficiency and equity; the cost-benefit analysis adds a moral dimension to the principle of utility, being a basic instrument for increases in water coverage; the high IANC non-billed water index shows the economic inefficiency of the tariff policy, overshadowing the ethical and bioethical considerations evidenced. Bioethics of protection is recommended as an addendum to the Tariff Policy, aimed at universalizing water service for the benefit of the most vulnerable population.