bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Characterization and Biological Activities of Jandaíra Stingless Bee Products (Melipona subnitida, Ducke, 1911): A Brief Review
Authors: de Menezes Dantas Débora , Rodrigues dos Santos Barbosa Cristina , Silva Macêdo Nair , de Sousa Silveira Zildene , Rodrigues Bezerra Suieny , Henrique Bezerra Antonio , Lira da Silva José Bruno , Martins da Costa José Galberto , Sarmento Silva Tania Maria , Douglas Melo Coutinho Henrique , Assis Bezerra da Cunha Francisco 
Published: December 2023

AbstractMelipona subnitida (Ducke, 1911), a species of stingless bee, popularly known as Jandaíra, has a wide distribution in the Brazilian Northeast region, being an important pollinator of the Caatinga biome. This bee produces products such as honey, geopropolis, pollen (saburá) and wax that are traditionally used for therapeutic purposes and some studies report the biological properties, as well as its chemical composition. This review aimed to select, analyze and gather data published in the literature focusing on the chemical profile and bioactivities described for M. subnitida products. Data collection was carried out through the Capes Journal Portal platform, using the following databases: Web of Science, Scopus, and PubMed. Original articles published in English and Portuguese were included, with no time limitation. The chemical composition of M. subnitida products has been investigated through chromatographic analysis, demonstrating the presence of a variety of phenolic compounds, such as flavonoids and phenylpropanoids, among other classes of secondary metabolites. These products also have several biological activities, including antioxidant, healing, antinociceptive, anti‐inflammatory, antidepressant, antidyslipidemic, antiobesity, antifungal, antibacterial and prebiotic. Among the biological activities reported, the antioxidant activity was the most investigated. These data show that products derived from the stingless bee M. subnitida have promising bioactive compounds. This review provides useful information about the bioactivities and chemical profile of Melipona subnitida bee products, and a direction for future research, which should focus on understanding the mechanisms of action associated with the already elucidated pharmacological activities, as well as the bioactive properties of the main isolate's constituents identified in the chemical composition of these products.
Development of Phenyl‐substituted Isoindolinone‐ and Benzimidazole‐type Cereblon Ligands for Targeted Protein Degradation
Authors: Nie Xueqing , Zhao Yu , Tang Hua , Zhang Zhongrui , Liao Junzhuo , Almodovar‐Rivera Chelsi M. , Sundaresan Ramya , Xie Haibo , Guo Le , Wang Bo , Guan Hongqing , Xing Yongna , Tang Weiping 
Published: December 2023

AbstractThalidomide, pomalidomide and lenalidomide, collectively referred to as immunomodulatory imide drugs (IMiDs), are frequently employed in proteolysis‐targeting chimeras (PROTACs) as cereblon (CRBN) E3 ligase‐recruiting ligands. However, their molecular glue properties that co‐opt the CRL4CRBN to degrade its non‐natural substrates may lead to undesired off‐target effects for the IMiD‐based PROTAC degraders. Herein, we reported a small library of potent and cell‐permeable CRBN ligands, which exert high selectivity over the well‐known CRBN neo‐substrates of IMiDs by structure‐based design. They were further utilized to construct bromodomain‐containing protein 4 (BRD4) degraders, which successfully depleted BRD4 in the tested cells. Overall, we reported a series of functionalized CRBN recruiters that circumvent the promiscuity from traditional IMiDs, and this study is informative to the development of selective CRBN‐recruiting PROTACs for many other therapeutic targets.
Lichenoid mycosis fungoides: Report of a case with lichen planus‐like histopathologic features
Authors: Kianfar Nika , Ghanadan Alireza , Aryanian Zeinab , Etesami Ifa 
Published: December 2023

Key Clinical MessageMycosis fungoides is a diagnostic challenge. Herein, we report a case with marked lichenoid features in pathology assessments. After several biopsies and clinicopathologic correlation, the diagnosis of lichenoid mycosis fungoides was made.AbstractMycosis fungoides (MF) is a great imitator and mimicks other dermatoses clinically and histopathologically. We report a 61‐year‐old patient with 5‐year history of generalized violaceous patches and plaques. His biopsy revealed a marked lichenoid band‐like infiltrate of inflammatory cells along the basal layer with basal layer vacuolar changes; the diagnosis of lichen planus was first made histopathologically. Several biopsy specimens, clinicopathologic correlation, and immunohistochemistry findings confirmed the diagnosis of lichenoid MF. Awareness of peculiar histopathologic findings of MF is essential to avoid a potential misdiagnosis. When in doubt, multiple biopsies with other diagnostic methods should be employed.
Metallaphotocatalytic Platforms Based on Covalent Organic Frameworks for Cross‐Coupling Reactions
Authors: Jia Tongtong , Zhao Yukun , Song Wenjing , Zhao Jincai 
Published: December 2023

AbstractCooperation of transition metal catalysis with photocatalysis is an emerging powerful approach to achieve coupling reactions for the synthesis of important chemicals. Owing to their facilely modulated structures and properties via reticular chemistry, photoactive covalent organic frameworks (COFs) arise quickly in building metallaphotocatalytic platforms targeting more efficient and sustainable protocol. In this Minireview, we summarize the recent advances in COFs‐based (integrated) platforms to forge carbon‐carbon/heteroatom (C, B, N, O, P, and S, etc.) bonds via a variety of cross‐coupling reactions driven by light, with focuses on the engineering of COFs’ backbone, as well as the organization mode of COFs and metal site promoted catalytic performance. We also highlight the essential role of the underlying electron/energy processes in metallated COFs platforms (M@COFs). Aiming to guide catalysts’ design to achieve more efficient performance or currently challenging transformations, we give our perspectives in this under‐developed yet promising field.
6‐Aryl‐Substituted Harmanium Derivatives as Light‐Up Probes for Fluorimetric DNA Detection and Staining of Eukaryotic Cells
Authors: Groß Philipp , Hoffmann Renée S. , Müller Mareike , Schönherr Holger , Ihmels Heiko 
Published: December 2023

AbstractNine 6‐aryl‐substituted harmanium derivatives were synthesized by Suzuki‐Miyaura coupling of 6‐bromoharmane with arylboronic acids and subsequent N2‐benzylation. Depending on the substitution pattern of the aryl group the emission maxima cover a range between λfl=445 and 529 nm with quantum yields of Φfl=<0.01–0.92. The interactions with duplex DNA were investigated by photometric and fluorimetric titrations as well as CD and LD spectroscopy. These ligands bind to DNA by intercalation with binding constants of Kb=1–3×104 M−1. It was demonstrated by fluorescence microscopy that the 2‐benzyl‐6‐(3‐methoxyphenyl)harmanium derivative operates as a fluorescent light‐up probe in the complex biological environment of eukaryotic cells, namely in NIH 3T3 mouse fibroblasts, as it stains the perinuclear cytoplasm and distinct substructures of the nucleus preferentially as compared with the rest of the nucleoplasm.
Macrocycle‐Based Hierarchically Porous Hydrogen‐Bonded Organic Frameworks
Authors: Wang Hui , Wang Danbo , Wu Yumin , Zhao Yingjie 
Published: December 2023

AbstractHydrogen‐bonded organic frameworks (HOFs) are porous crystalline materials. The pores in HOFs are usually non‐covalent extrinsic pores constructed through the formation of the framework. Supramolecular macrocycles with intrinsic pores in their structures are good candidates for constructing HOFs with intrinsic pores from the macrocycles themselves, thus leading to hierarchically porous structures. Combining the macrocycle and HOFs will endow these hierarchically porous materials with enhanced properties and special functionalities. This review summarizes recent advances in macrocycle‐based HOFs, including the macrocycles used for constructing HOFs, the hierarchically porous structures of the HOFs, and the applications induced by the hierarchically HOFs porous structures. This review provides insights for future research on macrocycle‐based hierarchically porous HOFs and the appropriate applications of the unique structures.
Unmasking the Electrochemical Stability of N‐Heterocyclic Carbene Monolayers on Gold
Authors: Dominique Nathaniel L. , Chandran Aruna , Jensen Isabel M. , Jenkins David M. , Camden Jon P. 
Published: December 2023

AbstractN‐heterocyclic carbene (NHC) monolayers are transforming electrocatalysis and biosensor design via their increased performance and stability. Despite their increasing use in electrochemical systems, the integrity of the NHC monolayer during voltage perturbations remains largely unknown. Herein, we deploy surface‐enhanced Raman spectroscopy (SERS) to measure the stability of two model NHCs on gold in ambient conditions as a function of applied potential and under continuous voltammetric interrogation. Our results illustrate that NHC monolayers exhibit electrochemical stability over a wide voltage window (−1 V to 0.5 V vs Ag|AgCl), but they are found to degrade at strongly reducing (< −1 V) or oxidizing (>0.5 V) potentials. We also address NHC monolayer stability under continuous voltammetric interrogation between 0.2 V and −0.5 V, a commonly used voltage window for sensing, showing they are stable for up to 43 hours. However, we additionally find that modifications of the backbone NHC structure can lead to significantly shorter operational lifetimes. While these results highlight the potential of NHC architectures for electrode functionalization, they also reveal potential pitfalls that have not been fully appreciated in electrochemical applications of NHCs.
Synthesis, Structures and Photophysical Properties of Asymmetric Fulvene‐[b]‐fused BODIPYs
Authors: Zhao Mengna , Xu Shaoyu , He Chun , Zhou Yifeng 
Published: December 2023

AbstractHerein, we developed a one‐pot procedure to synthesize novel fulvene‐[b]‐fused BODIPYs from α‐(2‐alkynylphenyl)‐pyrrole and acylpyrrole, using 5‐exo cyclization as the key transformation. Compared to benzene‐[b]‐fused BODIPYs, although they have similar chemical compositions, their structures and properties significantly differ from each other, which can be attributed to the less aromaticity of the fulvene linker than benzene. Notably, fulvene‐[b]‐fused BODIPY 1 b exhibits helical‐twisted core skeleton, intensified red‐shifted absorption, and peak fluorescence. In addition, the pathway of this one‐pot reaction and the mechanism of POCl3 mediated 5‐exo cyclization have been proposed by a combining experimental and computational study.
Fault detection and diagnosis for chemical processes using dynamic global–local preserving projections
Authors: Chen Youqiang , Yang Fan , Bai Jianjun , Zou Hongbo 
Published: December 2023

AbstractMost traditional multivariate statistical monitoring methods require an assumption that the observation values at a certain moment and a past moment are statistically independent. However, in actual chemical and biological processes, the sample at a certain moment is often affected by the previous moment. Therefore, given the problem of more false alarms and poor detection ability based on the traditional principal component analysis, this article proposes a dynamic global–local preserving projections (DGLPP) algorithm. Unlike dynamic local preserving projections (DLPP) and dynamic principal component analysis (DPCA), DGLPP controls the global and local information retained in the dimensionality reduction data by introducing weight coefficients, which makes the algorithm applicable to more types of industrial processes. Moreover, new parameter determination methods are also proposed for improved detection and diagnosis. Through the improved contribution graph method, we can see the influence degree of each variable on the fault, to monitor and isolate the fault. Finally, by verifying the operation of the multivariable process and two practical cases, the results show that compared with DPCA, DLPP, and global local retained projection (GLPP) methods, the performance under this method has been significantly improved.
The congenital muscular dystrophies
Authors: Topaloğlu Haluk , Poorshiri Bita 
Published: December 2023

AbstractBackgroundCongenital muscular dystrophies (CMDs) are genetically and clinically heterogeneous inherited conditions. Onset is typically within the first year of life. Most CMDs are autosomal recessive, except for de novo dominant mutations in LMNA‐related muscular dystrophy and some collagen‐6‐associated disorders.ResultsCMD is characterized by progressive muscular weakness, hypotonia, multiple contractures with a variable degree, spinal stiffness, delay in motor milestones acquisition, and histologically dystrophic lesions. Also, some forms of CMD may feature structural and myelination abnormalities on brain magnetic resonance imaging, intellectual impairment, and structural abnormalities of the eye. Muscle biopsy specimens exhibit a dystrophic pattern, but the appearance is quite variable depending on the different stages and severity of the disorder. The prevalence of CMD is estimated to be one in 100 000 people. Over the last few years, with advances in molecular genetic diagnostics, knowledge about neuromuscular disorders, particularly CMDs, has increased dramatically. Thus, the incidence may be higher than originally thought.ConclusionThis article reviews the recent achievements related to the clinical, diagnostic, pathogenic, and therapeutic aspects of CMDs.
Cache allocation policy based on user preference using reinforcement learning in mobile edge computing
Authors: Li Nianxin , Zhai Linbo , Song Shudian , Zhu Xiumin , Li Yumei , Yang Feng 
Published: December 2023

SummaryIn mobile edge computing (MEC), due to the limited computing resources and power of mobile augmented reality (MAR) devices, cache identification results which can reduce power consumption and executing time of mobile devices are the solution to process MAR tasks. In this paper, we study an allocation cache problem in MAR systems. The allocation cache problem is formulated as maximizing the cache utility of cache hit ratio and user preference factor. To solve this problem, a cache resource allocation and cache space adjustment policy for edge computing systems is proposed. We also propose an improved double deep Q‐network (DDQN) algorithm to learn this policy. Simulation results show that the policy greatly improves the cache hit ratio compared with the traditional caching policy.
Applications of dialectical behavioural therapy in the perinatal period: A scoping review
Authors: Hellberg Samantha N. , Bruening Amanda B. , Thompson Katherine A. , Hopkins Tiffany A. 
Published: December 2023

AbstractPsychological distress is the most common complication of pregnancy. High‐risk concerns can include severe emotion dysregulation, suicidality and self‐injury, and health risk behaviours, which bear substantial consequences for caregivers and families. Yet, effective, comprehensive interventions for high‐risk caregivers have received limited attention. Dialectical behaviour therapy (DBT) is a frontline treatment for such concerns. Accordingly, we conducted a scoping review on the implementation of DBT in the perinatal period. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines were followed. Seven studies were identified; study designs included case studies and single‐arm pilot trials. Most studies used DBT‐informed protocols with significant adaptations, few included multiple components of DBT (i.e. skills group, individual therapy, phone coaching and consultation team), and none met criteria for adherent delivery of all four modes of DBT treatment. Findings suggest DBT‐informed interventions may be successfully implemented to treat a range of perinatal mental health symptoms, including borderline personality disorder, depression, anxiety, and post‐traumatic stress, and to promote emotion regulation and positive parenting behaviours. While results provide preliminary support for perinatal DBT, this literature is scant and empirical rigour considerably lacking. Clinical implications and future directions are outlined to aid researchers and providers in addressing the ongoing perinatal mental health crisis and developing sorely needed interventions to address the needs of high‐risk caregivers.
Tailoring the Brønsted acidity of Ti−OH species by regulating Pt−TiO2 interaction
Authors: Meng Fanchun , Yang Xinchun , Zhao Shichao , Li Zhuo , Qi Yuntao , Yang Huimin , Qin Yong , Zhang Bin 
Published: December 2023

AbstractBifunctional catalysts comprising metal and acid sites are commonly used for many reactions. Interfacial acid sites impact intermediate reactions more than other sites. However, controlling the type and amounts of interfacial acid sites by regulating metal‐support interaction (MSI) via traditional methods is difficult. Thus, the influence of MSI on interfacial acid sites remains unclear. We prepared Pt‐mTiO2/α‐Al2O3 (m represents the cycle number of TiO2) catalysts via atomic layer deposition (ALD). New Brønsted acid sites were generated via Pt−TiO2 interaction, and the acidity was precisely regulated by regulating Pt−TiO2 interaction by changing the TiO2 nanolayer thickness. We chose levulinic acid (LA) hydrogenation as a model reaction. The catalytic activity varied with the TiO2 nanolayer thickness and was linearly correlated with the Ti−OH species (Brønsted acid) content. Pt‐40TiO2/α‐Al2O3, with the highest acid site content of 0.486 mmol/g, exhibited the best catalytic activity. Hydrogen spillover and water dissociation at the Pt−TiO2 interface promoted Ti−OH species generation.
A novel extendable multilevel inverter for efficient energy conversion with fewer power components: Configuration and experimental validation
Authors: Meraj Sheikh Tanzim , Yu Samson Shenglong , Rahman Md. Siddikur , Arefin Ahmed Amirul , Lipu Molla Shahadat Hossain , Trinh Hieu 
Published: December 2023

SummaryMultilevel inverters (MLIs) are widely used in various sectors of power electronics. Some major benefits of using MLI are the high‐quality voltage output, harmonic reduction, and efficiency. However, MLIs also bear a range of disadvantages including an excessive number of components, high total standing voltage (TSV), and complicated control scheme. Thus, a novel cross‐switched neutral point clamped (CSNPC) nine‐level inverter is proposed. Many of the suggested MLIs use a large number of DC supplies and additional switches that are not fully utilized and generate high power loss. However, the proposed MLI topology has a smaller number of power electronic switches and DC supplies, leading to higher energy efficiency. Moreover, a simplified high frequency modulation technique, named hysteresis‐band‐based discontinuous pulse width modulation (DPWM) is devised to control the proposed MLI. This modulation scheme has effectively minimized capacitor voltage imbalance. Furthermore, the designed structure is extendable to a modular MLI, without any additional H‐bridge circuit. To verify its benefits over other recent similar types of MLIs, a thorough comparison is presented for the number of components and power losses. The proposed MLI has showed 95.54% efficiency, and the modular CSNPC can achieve a total harmonic distortion (THD) of 6.43%.
Outage and throughput performance analysis of smart UAV‐assisted full‐duplex NOMA‐based energy harvesting cognitive radio networks
Authors: Kumar Bag Jayanta , Samanta Dipak , Kumar De Chanchal , Chandra Abhijit 
Published: December 2023

SummaryIn this paper, the throughput and outage performance for an unmanned aerial vehicle (UAV)‐assisted non‐orthogonal multiple access (NOMA)‐based hybrid cognitive radio (CR) network are examined under m‐Nakagami fading channel. To be more specific, a secondary source transmitter (
) broadcasts a NOMA‐enabled mixed signal to secondary destinations via UAV relay, which operates in full‐duplex (FD) mode and employs decode‐and‐forward protocol. In our approach, an energy harvesting (EH) circuit is employed at both
and UAV to harvest energy from the PU radio frequency (RF) signals. These secondary transmitters are also incorporated with energy detector (ED) circuit as well, which detects the activity of the primary user (PU). The status of PU to be busy or idle is confirmed on the basis of the energy detector's results. In turn, this drives
and UAV to switch between underlay and overlay protocols in an adaptive manner to increase spectrum efficiency (SE). The closed form mathematical expressions of the secondary outage probability for NOMA‐based UAV equipped CR networks under imperfect successive interference cancellation (i‐SIC) conditions have been evaluated. The administration of the power allocation policy at the
and UAV is assessed while maintaining the PU quality of service (QoS). Finally, MATLAB simulation testbed has been used to verify all the analytical closed form expressions.
Mechanical properties and fracture surface roughness of thermally damaged granite under dynamic splitting
Authors: Qian Yijin , Jia Peng , Mao Songze , Lu Jialiang 
Published: December 2023

AbstractIn order to understand the mechanical properties and the fracture surface roughness characteristics of thermally damaged granite under dynamic splitting, dynamic Brazilian splitting tests were conducted on granite samples after thermal treatment at 25, 200, 400, and 600°C. Results show that the dynamic peak splitting strength of thermally damaged granite samples increases with increasing strain rate, showing obvious strain‐rate sensitivity. With increasing temperature, thermally induced cracks in granite transform from intergranular cracks to intragranular cracks, and to a transgranular crack network. Thermally induced damages reduce the dynamic peak splitting strength and the maximum absorbed energy while increasing the peak radial strain. The fracture mode of the thermally damaged granite under dynamic loads is mode II splitting failure. By using the axial roughness index , the distribution ranges of the wedge‐shaped failure zones and the tensile failure zones in the fracture surfaces under dynamic Brazilian splitting can be effectively identified. The radial roughness index is sensitive to the strain rate and temperature. It shows a linear correlation with the peak splitting strength and the maximum absorbed energy and a linear negative correlation with the peak radial strain. can be used to quantitatively estimate the dynamic parameters based on the models proposed.
Synthesis, Reactivity and Application of Vinyl Sulfoximines and Vinyl Aminosulfoxonium Salts
Authors: Gais Hans‐Joachim 
Published: December 2023

AbstractThe combination of a sulfonimidoyl and aminosulfoxonium group with a double bond renders vinyl sulfoximines and vinyl aminosulfoxonium salts particularly versatile classes of compounds in organic synthesis. The discussion of vinyl sulfoximines includes in addition to the synthesis, the Michael reaction and its application in asymmetric synthesis, the synthesis, structure and application of α‐lithiovinyl sulfoximines, the nickel‐catalyzed and copper‐mediated anionic cross‐coupling reaction of α‐metallovinyl sulfoximines, the synthesis of acyclic and cyclic dienyl vinyl sulfoximines and the ring‐closing metathesis, the hydroalumination and reductive Pauson‐Khand reaction, the nickel‐catalyzed cross‐coupling reaction, the vinyl‐allyl isomerization, the cycloaddition, and the cyclization. The discussion of vinyl aminosulfoxonium salts includes in addition to the synthesis, the Michael reaction, the ethylenation of protic nucleophiles, the synthesis of allyl aminosulfoxonium salts and the nucleophilic substitution, the synthesis of allyl aminosulfoxonium ylides and the imino ester aziridination, the synthesis of vinyl aminosulfoxonium ylides, the synthesis of alkynes and dihydrofurans, the nickel‐catalyzed cross‐coupling reaction, and the intramolecular substitution of the amino group.