bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term Results of arthroscopic arthrodesis of Ankle with excessive varus deformity by complete deltoid release technique
Authors: Khan Abdul Aleem , Zhang Kaibin , Li Yang , Jiang Yiqiu , Tao Tianqi , Gui Jianchao 
Published: October 2023

Abstract
Purpose
The objective of our study is to provide a better treatment option to patients with degenerative ankle deformities with varus of greater than 250 to achieve painless mobilization.
Methods
Our senior Surgeon performed arthroscopic fusion for varus ankle deformities of larger than 25 degrees in 64 of our patients. Prior to surgery, we managed our patients conservatively for a period of 6 months. Following surgery, we follow the patients for 6 up to 18 months. We used the curved curetteor and microfacture tool to release the deltoid ligament allowing us to fix larger degree of deformities. X-ray was used pre-operatively to assess the damage and deformity of the ankle and post operatively to assess the union during follow up. SPSS 17.0 windows software (Chicago,IL) was used for statistic to compare our group of patients with a groups of patients with ankle deformities of less than 25 0. The Wilcoxon Signed Rank (WSR) test was used for repeated measures. Categorical variables were compared using Fisher’s Exact (FE) test and the Mann–Whitney (MW) test was used to analyze pre-and postoperative AOFAS. We used the modified Mazur Grading System to evaluate the ankle union.
Results
The Union rate achieved in both Groups was ≥ 90%.
Conclusion
This technique is successful in treating varus ankle arthritis larger than 25 degrees.
Mass dependence of binding energy in three-nucleon system
Authors: Filikhin Igor , Kuzmichev Yury B. , Vlahovic Branislav 
Published: October 2023

Abstract
We consider the 3H nucleus within the AAA model that includes mass identical particles interacting through a phenomenological nuclear potential. We extend the three-nucleon Hamiltonian \(\beta{\widehat{{H}}}_{0}+{V}_{nucl.}\) using the parameter β = m0/m* that determines the variations m* of the averaged nucleon mass m0 = (mn + mP)/2. It was found that the 3H binding energy is a linear function of the mass m*/m0 when it changes within the ranges 0.9 < m* / m0 < 1.25. Thus, the relation between energy and mass is expressed by an analogy to the well-known formula E = mc2. This effect takes a place in small vicinity around the experimentally motivated value of the nucleon mass due to Taylor expanding the general relation E～1/m. The equivalent mass of a nucleon, defined by using this energy-mass dependence, can phenomenologically describe the effect of the proton/nucleon mass difference on 3N binding energy.
The role of cross-link in the treatment of thoracolumbar burst fractures with pedicle screw fixation at fracture vertebrae—a finite element analysis
Authors: Pan Junpeng , Liu Fumin , Huang Ruipeng , Xu Shaoqing , Zhao Chengliang 
Published: October 2023

Abstract
Objective: To study the role of cross-link in the treatment of thoracolumbar burst fractures (TLBF) with pedicle screw fixation at fracture vertebrae (PFFV), and to study the optimal placement of cross-link.
Methods: The thoracolumbar model of healthy volunteers was constructed by finite element analysis (FEA), and the TLBF model was established by osteotomy. The internal fixation methods of Through spinous process cross-link (ESPC), Excision spinous process cross-link (TSPC), and No cross-link (NC) were constructed, and three spinal models after internal fixation were removed after recovery also established. The displacement and range of motion (ROM) and the equivalent stress of pedicle screw and connecting rod were measured by simulating daily motions. Two independent sample t-test was used to compare the difference in displacement and ROM.
Results: The displacement and ROM of TSPC were the smallest, followed by ESPC, and NC was the largest. The displacement and ROM of TSPC were 20 % -30 % lower than NC in different motions, and those of ESPC were 10 % -20 % lower than NC in different motions. ESPC reduced the equivalent stress of pedicle screw of the vertebrae adjacent to the fracture vertebrae and increased the stress of connecting rod. After internal fixation was removed, the displacement and ROM of the excision spinous process spine in flexion and extension were greater than those of the intact spine.
Conclusion: Internal fixation with TSPC had higher stability and safety, and should be used in the treatment of TLBF with pedicle screw fixed at fracture vertebrae.
Liquid-liquid equilibria data and thermodynamic modeling for ternary system of mesityl oxide + diethoxymethane + water at 303.15, 313.15, 323.15 K under 101.325
Authors: li tao , Guo Hongyue , Li Qingsong , li Zhongtao 
Published: October 2023

Abstract

Liquid-liquid equilibria (LLE) data for the ternary mixture of mesityl oxide + diethoxymethane + water were measured at 303.15, 313.15, 323.15 K under 101.325 kPa. The extraction ability of mesityl oxide for separating diethoxymethane from water was evaluated using distribution coefficients (D) and selectivity coefficients (S). The reliability of experimental data of the ternary mixture was validated by the Bachman and Hand method, in which the linear correlation (R2) ≥ 0.99. This experimental data were correlated with the NRTL and UNIQUAC thermodynamic model with all of the RMSD values below 0.47% meaning that the ternary system had satisfactory agreement at temperatures studied. Both models successfully correlated experimental data.
Can low-dose intravenous immunoglobulin be an alternative to high-dose intravenous immunoglobulin in the treatment of children with newly diagnosed immune thrombocytopenia: A systematic review and meta-analysis
Authors: Ren Xiangge , Zhang Miaomiao , Zhang Xiaohan , Zhao Peidong , Zhai Wensheng 
Published: October 2023

Abstract
Intravenous immunoglobulin (IVIg) is a first-line treatment for children with newly diagnosed immune thrombocytopenia (ITP). Higher doses of IVIg are associated with a more insupportable financial burden to pediatric patients' families and may produce more adverse reactions. Whether low-dose IVIg (LD-IVIg) can replace high-dose IVIg (HD-IVIg) has yet to be established. We conducted a comprehensive literature search from the establishment of the database to May 1, 2023, and eventually included 22 RCTs and 3 cohort studies compared different dosages of IVIg. A total of 1989 patients were included, with 991 patients in the LD-IVIg group and 998 patients in the HD-IVIg group. Our results showed no significant differences between the two groups in the effective rate (LD-IVIg: 91% vs. HD-IVIg: 93%; RR: 0.99; 95%CI: 0.96–1.02) and the durable remission rate (LD-IVIg: 65% vs. HD-IVIg: 67%; RR: 0.97; 95༅CI: 0.89–1.07). Similar results were also found in the time of platelet counts (PC) starting to rise (MD: 0.01, 95%CI: -0.06–0.09), rising to normal (MD: 0.16, 95%CI: -0.03–0.35), and achieving hemostasis (MD: 0.11, 95%CI: -0.02–0.23) between the two groups. Subgroup analysis showed the effective rate of 0.6g/kg was equal to 1g/kg subgroup (91%) but higher than 0.8g/kg subgroup (82%), and a combination with glucocorticoid may contribute to effect enhancement (combined with glucocorticoid: 91% vs. IVIg alone: 86%) whether combined with dexamethasone (92%) or methylprednisolone (91%). Besides, the incidence rate of adverse reactions in the LD-IVIg group (3%) was significantly lower than the HD-IVIg group (6%) (RR: 0.61; 95༅CI: 0.38–0.98). So low-dose IVIg (≤ 1g/kg) is effective, safe, and economical, which can replace high-dose IVIg (2g/kg) as an initial treatment.
Diagnostic classification of autism spectrum disorder in the frequency domain using resting-state fMRI
Authors: haghighat hossein 
Published: October 2023

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with problems in social interactions, verbal and non-verbal communication, repetitive behaviors, and limited interests in a person. Considering the problems of diagnosing ASD using behavioral symptoms by experts, it seems necessary to propose computer-aided diagnosis systems (CADS) for ASD. We proposed an age-dependent CADS based on functional connectivity (FC) in the frequency domain for ASD using resting-state functional magnetic resonance imaging (rs-fMRI). Also, the features and classification accuracy obtained in the frequency and time domains were compared. First, preprocessing was performed on the rs-fMRI data. Then, group-independent component analysis (GICA) was used to obtain resting state networks (RSNs). This was followed by obtaining separate components of RSNs for each individual using dual regression. Then, coherence analysis was used to extract the features of FC in the frequency domain between RSNs. To consider the role of age in the classification process, three age groups of children, adolescents, and adults were considered, and feature selection for each age group was applied separately using an embedded approach, in which all WEKA classifiers were used simultaneously. Finally, classification accuracy was obtained for each age group. The proposed CADS was able to classify 95.23% in the children group, 88.1% in the adolescent group, and 92.8% in the adult group. In addition, the frequencies whose features obtained the most distinction in each age group were reported, which may play an effective role in diagnosing and monitoring the rehabilitation process in ASD.
Deltoid tuberosity index obtained by computed tomography versus radiography for measuring bone quality in proximal humeral fractures: a retrospective observational study
Authors: Labronici Pedro José , Pereira Lucas Fávero , Cabral Guilherme Guimarães , Magalhães Gabriela Sulz , Belangero William Dias , Pires Robinson Esteves , Silva Gustavo Waldolato , Dyer George S. M. , Giordano Vincenzo 
Published: October 2023

Abstract
Background
In cases of proximal humeral fractures, fracture severity and the patient’s osteoporotic condition should be assessed to achieve the best possible treatment outcomes. The Tingart measurement is commonly used to assess bone quality, but it can be problematic if the measurement area is affected by the fracture. Recently, the deltoid tuberosity index (DTI) has been developed as another index to evaluate bone quality. The aim of this study was to compare the efficacy of the DTI obtained by X-ray imaging with computed tomography (CT) in assessing bone quality for proximal humeral fractures.
Methods
Fifteen patients with proximal humeral fractures were included, and the images were assessed twice by two independent evaluators with an interval of 1 month between each assessment. According to DTI values measured by X-ray, values greater than 1.4 were considered positive for osteoporosis, while values less than or equal to 1.4 were considered negative. The inclusion criteria were patients over 18 years old with a proximal humeral fracture who underwent anteroposterior radiography and CT. Pathological fractures, pre-existing humeral fractures, and metabolic diseases were excluded.
Results
There was good agreement between the CT and X-ray measurements. However, there were significant differences between them, with the CT measure being higher than the X-ray measure in 46.7% of the evaluations. The best cut-off points for diagnosing osteoporosis were found to be the same for CT and DTI: 1.4. CT diagnosis had an accuracy of 73.3%, a sensitivity of 65.2%, and a specificity of 78.4% when compared to X-ray diagnosis. False-positive diagnoses were 14.3%, and false-negative diagnoses were 13.3%.
Conclusions
CT can be considered a good method for diagnosing osteoporosis in proximal humeral fractures. The findings of this study allow the surgeon to use the CT as a new tool to make the diagnosis of osteoporosis and to define the patient under risk for surgical procedure.
Safety and Efficacy of Botulinum toxin Toxin A combined with Radiofrequency Home- Device for Rejuvenation
Authors: Hai Su , Qin XiaoLei , Li Kai , Yao MeiJuan , Chen Meijiao , Wang Lin , Luo Yingqi 
Published: October 2023

Abstract
Botulinum toxin type A (BoNT-A) is confirmed to be effective and one of the most widely used cosmetic injection techniques for treating dynamic wrinkles. In principle, it has been proven to reduce wrinkles by inhibiting the release of acetylcholine from presynaptic nerve endings, causing chemical denervation and resultant muscle paresis [1-3]. To maintain the effects continuously, continuous injections at regular intervals are required because the neuronal and muscular changes that occur after BoNT-A administration are completely reversible, and the duration of maintenance is limited [4]. Furthermore, it can only improve dynamic wrinkles, not wrinkles and lines that have already formed. In recent times, many studies have reported clinical benefits of radiofrequency (RF) home-use devices in reducing wrinkles on the skin by heating dermal tissue and firming collagen fibers[5-7]. These devices are highly suitable for daily skincare maintenance or for prolonging the duration of results after undergoing aesthetic procedures, with their safety and efficacy well-established [8, 9].In this study, we aimed to assess the safety and efficacy of home-use RF device combined with botulinum toxin A treatment for periocular wrinkles.
Efficient Atrazine Degradation and Toxicity Assessment Using ZnO-Cerium Catalysts: A Path Towards Environmental Remediation
Authors: Cesar Pedro , Caetano Aline , Chagas Pricila , Lopes Paloma , Carvalho Iara 
Published: October 2023

Abstract
Atrazine, a widely used chlorinated pesticide, poses a significant threat to the environment due to its persistence and potential toxicity to non-target organisms. In this study, we investigated the efficiency of various catalysts in the photocatalytic degradation of atrazine and assessed the toxicity of the degradation products on the nematode Panagrellus redivivus. Our research aimed to shed light on the environmental fate of atrazine and the potential hazards associated with its degradation. We synthesized zinc oxide (ZnO) catalysts doped with cerium (Ce) at different concentrations (ZnOCe1% and ZnOCe10%) and compared their performance to direct UV photolysis. The results demonstrated that ZnOCe1% and ZnOCe10% exhibited superior catalytic efficiency in degrading atrazine compared to pure ZnO and photolysis. The degradation of atrazine led to a reduction in mortality rates of P. redivivus to negligible levels, indicating a potential mitigation of toxicity. Furthermore, we evaluated the toxicity of atrazine and its degradation intermediates on P. redivivus. Interestingly, we found that the toxicity of atrazine followed a hump-shaped dose-response curve, suggesting that even low concentrations of atrazine can have significant adverse effects. Additionally, the formation of intermediates during photocatalysis produced varying toxic effects, with ZnO-mediated intermediates showing more pronounced toxicity, as evidenced by reduced body sizes and impaired behavior. These findings underscore the importance of understanding the dynamics of atrazine toxicity, the efficiency of catalysts in its degradation, and the potential hazards posed by degradation intermediates. Our study contributes to the broader field of environmental contamination and toxicology, highlighting the need for continued research on the fate and effects of atrazine in the environment.
Attosecond Core-Level Absorption Spectroscopy Reveals the Electronic and Nuclear Dynamics of Molecular Ring-Opening
Authors: Biegert Jens , Severino Stefano , Reduzzi Maurizio , Summers Adam , Sun Hung-Wei , Chien Ying-Hao , Ziems Karl Michael , Gräfe Stefanie 
Published: October 2023

Abstract

We show that attosecond core-level spectroscopy is a powerful tool for investigating molecular dynamics due to its combined attosecond temporal resolution and the broad coherent spectrum that allows deciphering the signatures of nuclear and electronic motion through their different energetic signatures. The method reveals the correlated real-time electronic and nuclear wave packet dynamics nonadiabatic transitions across conical intersections, identifies electronic and nuclear coherences, and registers symmetry changes directly in the x-ray absorption spectrum. We demonstrate the method's efficacy to unveil the entire time history of the ring-opening dynamics of furan. The investigation establishes attosecond core level spectroscopy as a potent method to investigate the real-time dynamics of photochemical reaction pathways in molecular systems.
Appropriate evaluation of rapid evolutionary responses to seasonal environmental variability in a wild Drosophila population
Authors: Ueno Takahisa , Takenoshita Akiko , Hamamichi Kaiya , Sato Mitsuhiko P. , Takahashi Yuma 
Published: October 2023

Abstract
Seasonal environmental change is one of the most rapid and striking environmental variables. Although relatively rapid adaptation to environmental changes over several years or several decades has been described in many taxa, rapid responses to seasonal environments are delicate, and therefore, the detection of the evolutionary responses requires sensitive methods. Here, we examined the evolutionary response to seasonal environmental changes in terms of thermal tolerance and morphological traits using Drosophila lutescens collected at the spring and autumn periods in a single location. We first demonstrated that flies in the two seasonal periods were almost genetically identical using double-digest restriction site-associated DNA sequencing and analysis. With an experimental design that eliminated the effect of possible confounding environmental factors that influence thermal tolerance, we showed that the heat tolerance of D. lutescens was significantly higher in the autumn than in the spring. Furthermore, cold tolerance was slightly higher in the spring than in the autumn. Although wing length and thorax length did not change significantly between seasons, the ratio of wing length to thorax length changed significantly between them. These results indicate that seasonal environmental heterogeneity can induce evolution within a year. The present study demonstrates rapid evolutionary responses to environmental fluctuations.
Evaluation of neutralizing capacity of tixagevimab plus cilgavimab: a case-series study with comparison to a vaccinated population
Authors: Gillot Constant , Bayart Jean-Louis , Maloteau Vincent , Dogné Jean-Michel , Douxfils Jonathan , Favresse Julien 
Published: October 2023

Abstract
AZD7442 (150 mg of tixagevimab plus 150 mg cilgavimab) has been approved for the pre-exposure prophylaxis of COVID-19 and for the treatment of adults and adolescents with COVID-19 who do not require supplemental oxygen and who are at increased risk of severe COVID-19. In this study, two patients received AZD7442 for immunoprophylaxis. A cohort of subject who had received the BNT162b2 mRNA COVID‐19 vaccine has been included to compare strategies. Neutralizing antibodies (NAbs) against several variants were measured (wild-type, Alpha, Beta, Gamma, Delta, Omicron BA.5 and XBB.1.5). Binding antibodies have also been measured. NAbs T1/2 for AZD7442 was 8.1 days (95% CI: 5.1–19.5 days) and was 11.8 days (95% CI: 7.9–23.7 days) for the primo-vaccination cohort. The time to reach NAbs negativity was 108.3 days (95% CI: 66.9–130.7) for AZD7442 compared to 95.4 days (95% CI: 31.0–119.7 days) for primo-vaccination cohort. The time to reach NAbs negativity differs between variants with the maximum value obtained for the Alpha (i.e., 101.1 days (95% CI: 30.0–135.4 days)) and the minimum obtained for the Beta (i.e., 61.2 days (95% CI: 37.8–77.1 days)). Our results reinforces the need of reviewing the use of AZD7442 in relation to variant of concern and potentially adapting its administration schedule. AZD7442 could be indicated for short-term prophylaxis in frail patients who may be acutely exposed to SARS-CoV-2.
Molecular Junctions for Terahertz Switches and Detectors.
Authors: Hnid Imen , Yassin Ali , Arbouch Imane , Guérin David , Dyck Colin van , Sanginet Lionel , Lenfant Stéphane , Cornil Jérôme , Blanchard Philippe , Vuillaume Dominique 
Published: October 2023

Abstract

Molecular electronics targets tiny devices exploiting the electronic properties of the molecular orbitals, which can be tailored and controlled by the chemical structure/conformation of the molecules. Many functional devices have been experimentally demonstrated; however, these devices were operated in the low frequency domain (mainly, dc to MHz). This represents a serious limitation for electronic applications, albeit molecular devices working in the THz regime were theoretically predicted. Here, we experimentally demonstrate molecular THz switches at room temperature. The devices consist of self-assembled monolayers of molecules bearing two conjugated moieties coupled through a non-conjugated linker. These devices exhibit clear negative differential conductance behaviors (peaks in the current-voltage curves), as confirmed by ab initio simulations, which were reversibly suppressed under illumination with a 30 THz wave. We analyze how the THz switching behavior depends on the THz wave properties (power, frequency), and we benchmark that these molecular devices would outperform actual THz detectors.
Sentiment Analysis of Tweets Using Machine Learning
Authors: Rasalkar Prateek , Patel Prof.Javed , Velankar Vikram , Chordiya Naman 
Published: October 2023

Abstract
Twitter is social networking platform were users can post updates in form of tweets to friends/relatives, etc. It has grown to such an extent that it has a giant dataset of the so-referred to as sentiments. Sentiment analysis of twitter is the study of feelings, emotions based on the tweets. In this paper, we have introduced an approach based on Information Gain and object extraction method (most repeating words). In addition, we also propose a sentiment analysis model to classify the most repeated words is either positive or negative. Its goal is to more effectively study sentiment. This model excelled in accurately and effectively analysing emotions.[5]
Anionic Nanoplastic Contaminants Promote Parkinson’s Disease-Associated α-Synuclein Aggregation
Authors: Liu Zhiyong , Sokratian Arpine , Duda Addison , Xu Enquan , Stanhope Christina , Fu Amber , Strader Samuel , Li Huizhong , Yuan Yuan , Bobay Benjamin , Sipe Joana , Bai Ketty , Lundgaard Iben , Liu Na , Hernandez Belinda , Rickman Catherine Bowes , Miller Sara , West Andrew 
Published: October 2023

Abstract
Recent studies have identified increasing levels of nanoplastic pollution in the environment. Here we find that anionic nanoplastic contaminants potently precipitate the formation and propagation of α-synuclein protein fibrils through a high-affinity interaction with the amphipathic and non-amyloid component (NAC) domains in α-synuclein. Nanoplastics can internalize in neurons through clathrin-dependent endocytosis, causing a mild lysosomal impairment that slows the degradation of aggregated α-synuclein. In mice, nanoplastics combine with α-synuclein fibrils to exacerbate the spread of α-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of α-synuclein inclusions in dopaminergic neurons in the substantia nigra. These results highlight a potential link for further exploration between nanoplastic pollution and α-synuclein aggregation associated with Parkinson’s disease and related dementias.