bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of oscillation of a dam-plate of variable thickness
Authors: Khudayarov Bakhtiyar , Tukhtaboev A.A. , Kucharov O.R. , Turaev Fozilzhon , Yuldashev Nurilla 
Published: October 2023

The hereditary theory of viscoelasticity has provided ample opportunities for describing the dynamic processes of deformation of various materials. However, the implementation of these possibilities in many cases is difficult due to the lack of an adequate mathematical apparatus, especially in the study of dynamic processes in viscoelastic systems. There are fundamental reasons to believe that the apparatus of integral equations is very promising in this sense. The use of modern computer technology capabilities makes it possible to create effective mathematical modeling technologies for problems of great complexity, which include problems of dynamics and dynamic stability of viscoelastic elements of thin-walled structures with variable stiffness. Mathematical models of dynamic problems are constructed, efficient computational algorithms are developed, and forced vibrations of a dam-plate with variable stiffness are studied. The results of studies of problems on vibrations of a dam-plate of variable thickness are given, taking into account the viscoelastic properties of the material, the hydrodynamic pressure of water, soil and seismic load. Figs.:3, Refs.: 22 titles.
Application of the method of analysis of hierarchies for the selection of the optimal model of consolidation of IT resources of the SFD of Ukraine
Authors: Ilin Serhii , Kholod Ievgenii , Maznychko Andrij , Horodnycha Lubov 
Published: October 2023

The selection of the optimal technology for the consolidation of information resources from the information support of the State Register of Documents of the Documentation Insurance Fund of Ukraine was carried out among technologies IaaS, PaaS, SaaS, DaaS, web applications, etc.
This multi-criteria problem with a large number of factors of different dimensions was solved using the method of analysis of hierarchies. Figs.:1. Tabl.: 2, Refs.: 15 titles.
Selection Criteria for Repurposing Oil And Gas Well to Geothermal Heat Extraction
Authors: Merzoug Ahmed , Okoroafor Rita Esuru 
Published: October 2023

Abstract
Oil and gas wells are generally plugged and abandoned when they reach the end of their economic life. Thus repurposing these wells to harness the geothermal energy was supported as a way to reduce the abandonment expenses for the operators and cheaper access to the deeper formation with high temperatures for a geothermal operator. Oil and gas wells are drilled in different fields with different reservoir properties and well completion. This work is a numerical modeling study to understand the effect of rock properties (reservoir temperature, thickness, permeability, and porosity) on the power generation capacity. This study combines the two major challenges of injectivity and energy production as a ratio to define the major reservoir properties for optimum geothermal system circulation. This work also investigates the different oil and gas well completion (number of casings and their associated depth) on the heat losses in the wellbore for different circulation rates This work can serve as a roadmap for screening wells within a field for better geothermal energy production.
Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition.
Authors: Nakamura Tetsuya , Wei Janet , Wood Thomas , Flaherty Kathleen , Fitch Olivia , Enny Alyssa , Andrescavage Ali , Brazer Danielle , Navon Dina , Cohen Hannah , Shanabag Anusha , Kuroda Shunya , Stewart Thomas , Braasch Ingo 
Published: October 2023

Abstract
The mechanisms of the pectoral girdle transformation at the origin of terrestrial locomotion in vertebrates remains an outstanding problem in evolutionary biology. 1. The loss of dermal bones and the enlargement of endochondral bones resulted in the disarticulation of the pectoral girdle from the skull and the formation of the neck during the fish-to-tetrapod transition2-5. Despite the functional implications of this skeletal shift in the emergence of terrestrial vertebrates, the underlying genetic-developmental alterations have remained enigmatic. Here, we discovered that in zebrafish pectoral girdle mesodermal cells expressing gli3, a transcription factor in the Hedgehog signaling pathway, contribute to both dermal and endochondral bones. We show that Gli3 regulates expression of activin A receptor type 1-like, a BMP type 1 receptor lost in tetrapod lineages, and thereby determines endochondral and dermal ossification. Intriguingly, Gli and Hedgehog compound knockout fish exhibited an unexpected combination of actinopterygian fish and stem-tetrapod pectoral girdle characteristics. These ontogenetic and anatomical data suggest that a trade-off between the two distinct ossification pathways is a deeply embedded developmental program in bony fishes, with potential for tuning of this trade-off to generate novel pectoral girdle forms akin to stem-tetrapods at the dawn of vertebrate terrestrialization.
Structural alignment: the link between diversity, specialization and development
Authors: Gisbert Oriol 
Published: October 2023

Abstract
This paper examines the relationship between diversity, specialization, and economic development by analysing various indicators applied to country exports data. Indicators of concentration reveal a non-linear relationship between diversity and income, suggesting a tendency to re-specialize at high income levels. Similar conclusions are drawn when considering the count of product specializations (RCA). On the contrary, economic complexity indices which incorporate information about countries’ diversity and products’ ubiquity, exhibit an exponential relationship with income. However, the challenge lies in associating the value of economic complexity with the underlying structure of a country. Using the Kullback-Leibler divergence, we show that economic development is associated with increasing alignment between a country's export structure and the share of goods in global demand. This alignment is achieved through specialization in central natural resources or through industrialization, which increases diversity. Finally, we show that industrialization is preferable as it promotes high alignment with global demand across all categories of goods.
Unveiling the Role of Teachers’ Self-Efficacy in Improving Job Happiness: Insights from Student and Parent Perspectives
Authors: Li Ying , Yang Fan , Hu Zhanshuo , Qi Zhanyong 
Published: October 2023

Abstract
Teachers' self-efficacy is closely associated with student and parent satisfaction, and the quality of school education directly affects parental satisfaction. This study aims to investigate the interplay between teachers’ self-efficacy, student satisfaction, and parental satisfaction in a specific city in China. Online questionnaires were utilized to gather data for analysis, aiming to enhance the quality of regional basic education through a comprehensive understanding of this tripartite relationship. The findings highlight the pivotal role of self-efficacy in improving teachers' job happiness, which is influenced by students' satisfaction and parental satisfaction. Factors such as teachers' academic level, learning background, and job satisfaction contribute to the development and augmentation of self-efficacy.
IL-17 Signaling in Primary Sclerosing Cholangitis Patient-Derived Organoids
Authors: Moreno Ana Sofia Garcia , Guicciardi Maria Eugenia , Wixom Alexander Q. , Jessen Erik , Yang Jingchun , Ilyas Sumera I. , Bianchi Jackie K. , Vairo Filippo Pinto e , Lazaridis Konstantinos N. , Gores Gregory J. 
Published: October 2023

Abstract
The pathogenesis of primary sclerosing cholangitis (PSC) is unclear, although studies implicate IL-17A as an inflammatory mediator in this disease. However, a direct assessment of IL-17 signaling in PSC cholangiocytes is lacking. In this study we aimed to investigate the response of PSC extrahepatic cholangiocyte organoids (ECO) to IL-17A stimulation. Cholangiocytes obtained from PSC and non-PSC patients by endoscopic retrograde cholangiography (ERC) were cultured as ECO. The ECO were treated with vehicle or IL-17A and assessed by transcriptomics, secretome analysis, and genome sequencing (GS). Unsupervised clustering of all integrated scRNA-seq data identified 8 cholangiocyte clusters which did not differ between PSC and non-PSC ECO. However, PSC ECO cells demonstrated a robust response to IL-17 treatment, noted by an increased number of differentially expressed genes (DEG) by transcriptomics, and more abundant chemokine and cytokine expression and secretion. After rigorous filtering, GS identified candidate somatic variants shared among PSC ECO from unrelated individuals. However, no candidate rare variants in genes regulating the IL-17 pathway were identified, but rare variants regulating the MAPK signaling pathway were present in all PSC ECO. In conclusion, PSC and non-PSC patient derived ECO respond differently to IL-17 stimulation implicating this pathway in the pathogenesis of PSC.
Cytotoxicity and Toxicoproteomic Analysis of Pioglitazone Exposure in Human-derived Cardiomyocytes
Authors: Sultan Abdullah Al , Rattray Zahra , Rattray Nicholas J. W. 
Published: October 2023

Abstract
Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor gamma agonist widely used as an insulin sensitiser agent for type II diabetes mellitus. The heterogeneity of PGZ effects on cardiac tissue has remained controversial, as contradictory data exist in the literature. Nevertheless, a consensus has reported an associated increased risk of heart failure (HF) following chronic systemic exposure to PGZ, which has hampered its clinical use in diabetes management. The mechanism of PGZ-induced HF remains largely uncharacterised. Here, we report a comprehensive in vitro study combining a novel toxico-proteomic pipeline with cytotoxicity assays in human adult cardiomyocytes to elucidate mechanistic insights into PGZ cardiotoxicity and identify driver proteins associated with such effects. Cytotoxicity assay findings showed a significant loss of mitochondrial adenosine triphosphate production following PGZ exposure, suggesting that this decline underpins PGZ cardiotoxicity. Interestingly, proteomics analysis revealed that the mitochondrial dysfunction was attributed to PGZ mediating mitochondrial uncoupling and ultimately cardiomyocyte death. The type of cell death was also found to be related to the mitochondria—protein upregulation in the phosphoglycerate mutase family 5–dynamin-related protein 1 axis, suggesting mitochondrial-mediated necroptosis. Furthermore, our analysis suggested the potential activation of the interplay between the complement and coagulation systems and the disruption of the cytoskeletal architecture, which was primarily mediated through integrin-signalling pathways, responsible for PGZ-induced myocardial contractile failure. Collectively, our findings provide substantial mechanistic insight into PGZ adverse effects and may eventually provide the rationale for future optimisation of antidiabetic therapies. (239 words)
Photo-luminochromism of organic crystals arising from subtle molecular rearrangement
Authors: Yuan Wang Zhang , Zhao Zihao , Cai Yusong , Zhang Qiang , Li Anze , Zhu Tianwen , Chen Xiaohong 
Published: October 2023

Abstract
Photo-responsive colour-changing luminescent materials play an increasingly significant role in intelligent applications for their programmability. Nevertheless, current research mainly focuses on photochemical processes, while the photoluminescence (PL) transformation is scarcely accomplished by uniformly adjusting the aggregation mode. Here we show an impressive photo-luminochromism phenomenon from organic crystals (e.g. dimethyl terephthalate crystals) with PL varying from dark blue to purple and then to bright orange. This change is attributed to the subtle molecular rearrangement prompted by light irradiation. The through-space π-π interactions and moderate short contacts between ester groups are vital to enable this process. Furthermore, while the irradiated crystals own outstanding stability, the PL transformation is reversible with sufficient relaxation. These materials show promising applications in information storage and smart optoelectronic devices. These findings provide a new venue to the construction of smart photo-luminochromic materials with remarkable PL colour changes through molecular rearrangement.
Comparative Results of Triple Arthrodesis for the Management of Stage III Posterior Tibial Tendon Dysfunction between Rheumatoid and Non-Rheumatoid Patients
Authors: Demirel Mehmet , Şentürk Fatih , Mert Lezgin , Koyuncu Dağhan , Ersin Mehmet , Altan Murat , Kılıcoğlu Onder Ismet 
Published: October 2023

Abstract

Objective
Although the recommended treatment for stage III posterior tibial tendon dysfunction (PTTD) is triple joint complex fusion, the literature is limited on this topic. No study has specifically investigated the influence of rheumatoid arthritis (RA) on the outcomes of triple arthrodesis. This study aimed (1) to report mid-to-long-term results of triple arthrodesis for stage III PTTD and (2) to investigate the difference in the results of triple arthrodesis between rheumatoid and nonrheumatoid patients.
Methods
Thirty feet of 25 patients (16 females, 9 males; mean age 53, (39-71)) with stage III PTTD who were treated by triple arthrodesis were retrospectively analyzed. The mean follow-up was 82 (28 – 144) months. Patients were divided into two groups based on etiology: group ID (idiopathic PTTD) and group RA (PTTD secondary to RA). All clinical and radiographic outcomes were compared. The mean American Orthopedic Foot and Ankle Society (AOFAS) score was measured preoperatively and at the final follow-up. The 36-Item Short Form Survey (SF-36) and visual analog scale (VAS) were measured at the final follow-up.
Results
The mean AOFAS score improved from 57±6.81 (46–68) and 49±14.66 (18–79) preoperatively to 82±15.57 (44–94) and 77±14.46 (48–94) in group ID and group RA, respectively, with no significant difference between thepre- and postoperative values between the groups (p <.001). The mean VAS score at rest was 0.45±0.68 (0–2) in group ID and 1±1.08 (0–3) in group RA (p =.23). There was no significant difference in any SF-36 domain(p >.05) except for physical health, which was lower in the RA group (p =.002).
Conclusion
Although rheumatoid patients present with radiographically more severe flatfoot deformity, triple arthrodesis can provide similar satisfactory clinical and radiological outcomes with a low complication rate for stage III PTTD in rheumatoid patients as much as nonrheumatoid patients in long-term follow-up.
Level of Evidence: Retrospective cohort study, Level 3 Evidence
WITHDRAWN: Elevated Temperature Effects on Dynamics of Blade Growth and Erosion in Saccharina Latissima (Laminariales)
Authors: Ding Xiaowei , Timmermans Klaas R 
Published: October 2023

Abstract

The dynamics of blade growth and erosion in Saccharina latissima (Laminariales) control the final surface area of blades. The negative effects of elevated temperature on the surface area of blades may result from inhibition of growth and stimulation of erosion, eventually leading to release of carbon (C) and nitrogen (N). In this study, we investigated temperature effects on the growth and erosion of S. latissima blades incubated at ambient and elevated temperatures. For the first time, to our knowledge, growth rates of the meristem and total blade and the erosion rate of the distal blades were quantified simultaneously. Additionally, by analyzing the C and N content along with erosion rate, we could calculate the potential release of C and N to seawater. The results show a significant decrease in the relative growth rate and a significant increase in the erosion rate of the distal ends of blades when the temperature reached 23 ˚C. Results of the C and N analyses show that S. latissima released almost twice as much C and N at elevated temperatures than at ambient temperatures.
The primary porosity heterogeneity characteristics of braided river sandbody and implications for predicting the current physical properties heterogeneities
Authors: Yiming Yan , Zhang Liqiang , Xiaorong Luo 
Published: October 2023

Abstract

Understanding the heterogeneity of reservoirs is crucial for enhancing the efficiency of hydrocarbon exploration and development. The primary porosity of samples from modern braided river sands and outcrops of braided river sandstone was calculated using a model previously proposed by the authors. The characteristic parameters (Vx) for calculating primary porosity are closely related to the architectural-elemental configurations (AEC), and the AEC of braided river sand bodies (BRSD) has apparent effects on the distribution of the primary porosity heterogeneities. Analysis of our results has established a simple primary porosity heterogeneity model of BRSD. The center of braided river channel and mid-channel bars have excellent strong primary petrophysical properties with high primary porosity exceeding 38%. The contact areas between the braided river channel and channel bars exhibit relatively low primary porosities of less than 33%. The area between the center and edge of the braided bars and channels displays medium primary porosities. The nonlinear correlation in the Q-Q plot of the primary porosity and present porosity of samples from BRSD in the Ahe Formation is mainly caused by chemical diagenesis. The present porosity heterogeneity of BRSD in the Ahe Formation is less influenced by compaction and cementation, it predominantly arises from the differential of dissolution. Q-Q plots attempt to correlate the geological information from an individual sample with the heterogeneity of present porosity in BRSD. In addition, by utilizing Q-Q plots of the primary and current petrophysical properties of the sand body, the relative extent of heterogeneity modification caused by different diagenetic processes can be assessed. This assessment is crucial for modeling macroscopic models of physical properties during geological history periods.
Investigate the post-grouting bearing property of drilled piles in heavily weathered mudstone strata based on the O-cell test method
Authors: Ou Xiaoduo , Sang Runhui , Bai Lu , Jiang Jie 
Published: October 2023

Abstract
The study focuses on analyzing the bearing capacity of six cast-in-place drilled piles located in three distinct portions of the urban square at Ronghe East Station in Nanning was evaluated through static load testing using the Osterberg cell (O-cell) method, and the bearing deformation characteristics of post-grouting piles in heavily weathered mudstone stratum were analyzed. By fitting the resistance and relative displacement curves at the pile end and side, a load-settlement calculation method for post-grouting piles in a heavily weathered mudstone stratum was established by adopting the hyperbolic load transfer model, which has the tip hardening and the side softening. The accuracy of the method was verified through actual engineering test pile modeling and changed post-grouting piles' diameter and length to further examine their bearing properties. The bearing capacity exhibits a progressive increase with an increase in either the length or diameter of the pile. However, an effective length exists when the pile length is increased to increase the bearing capacity. The use of combined grouting technology can achieve a significant increase in bearing capacity, up to approximately 1.3 times, which can realize the economy and high efficiency of improving the bearing performance of pile foundations.
CoS2/V2O3 heterostructure with coffee ground derived carbon as superior composite anodes of sodium-ion batteries
Authors: Xue Yongqi , Wu Jun , Cheng Zhiqun , Xu Congxin , Cai Yurong , Ni Wenbin , Zhou Xiaochong 
Published: October 2023

Abstract
The poor ion transport kinetics and serious volumetric change of transition metal sulfides hinder their electrochemical applications. In this study, we introduced a heterostructure between CoS2 and V2O3 as an anode of sodium-ion batteries (SIBs) via a feasible hydrothermal method combining with a biomass carbon derived from coffee grounds (CG). The as-prepared CoS2/V2O3-CG composite retained a reversible capacity of 464.5 mAh g-1 after 300 cycles at 0.5 A g-1, exhibited an excellent rate capability of up to 8 A g-1 and a remarkable long-cycling life of over 2,000 cycles at 2 A g-1 with a capacity decay rate of less than 0.041% per cycle. The kinetic analysis indicated that CoS2/V2O3-CG composite exhibited a superior capacitive behavior, making it a high Na+ diffusion coefficient in SIBs. The enhanced electrochemical performances of composite can be primarily attributed to the CoS2/V2O3 heterostructure and porous biomass-derived carbon, which offers a built-in electric field and a large surface area, and effectively alleviates the volumetric expansion effect.
A novel aging-associated lncRNA prognostic signature for predicting immunotherapy and chemotherapy response in pancreatic cancer
Authors: Li Yan , Chen Yuling , Li Bo , Zheng Guoxing , Zang Chuanbing , Zhu Qingqing , Zhu Chengming , Ye Yuanchun 
Published: October 2023

Abstract
Background: Tumors commonly develop as individuals age, and their relationship is intricately connected yet remarkably unclear). On one hand, long non-coding RNAs (lncRNAs) affect the proliferation, invasion, metastasis, prognosis, and drug resistance of most tumors, including pancreatic cancer. On the other hand, increasing evidence suggests that lncRNAs are also widely involved in the aging process. Nevertheless, it remains unknown whether aging-associated lncRNAs impact the prognosis and immune microenvironment of pancreatic cancer.
Methods: Transcriptomic and clinical information of pancreatic cancer were obtained from TCGA databases. Aging-associated lncRNAs were enriched by co-expression analysis based on 500 aging-related genes in Aging Atlas database. Then aging-associated lncRNAs signature risk model was constructed by univariate, multivariate and Lasso Cox regression analysis. The receiver operating characteristic (ROC) curve, Kaplan-Meier analysis and nomogram were performed to evaluate the prognosis value and predictive ability. Patients in the PACA_PU databases were enrolled to verify the risk model as an external validation. ESTIMATE, single-sample gene set enrichment analysis (ssGSEA) and TIDE were used to analyze the immune microenvironment and immunotherapy response. And drug sensitivities were analyzed with the pRRophetic algorithm.
Results: A risk signature containing six aging-associated lncRNAs (RP11-731F5.2, PVT1, RP1-239B22.5, LINC01004, RP11-61J19.5 and RP11-132A1.4) was established and shown to be significantly associated with overall survival in pancreatic cancer patients. The ROC curve, nomogram and PCA analysis demonstrated the accuracy and stability of the risk model’s ability to predict prognosis as well as its good clinical utility. The ESTIMATE and ssGSEA results suggested a strong relationship between the aging-associated lncRNAs risk signature and immune infiltration of pancreatic cancer. The analysis of PD1, TIDE, TMB and MSI further demonstrated the effectiveness of this risk signature for predicting immunotherapy response. In addition, this risk signature was also useful for predicting the sensitivity of chemotherapeutic agents.
Conclusion: We constructed a novel aging-associated lncRNAs-derived risk signature with good prognostic value in pancreatic cancer that effectively predicted immunotherapy response and chemotherapeutic drug sensitivity.