bluuebunny/crossref_metadata_2025_split huggingface dataset:
β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling
Authors: Kim Hyung-Su , Kim Hyoung-June , Hong Yong-Deog , Son Eui Dong , Cho Si-Young 
Published: December 2023

AbstractSolar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin-derived peptide β-endorphin, which is known for its analgesic effect. However, little is known about the role of β-endorphin in UVB-exposed skin. Therefore, in this study, we aimed to explore the protective role of β-endorphin against UVB irradiation-induced damage to the skin barrier in normal human keratinocytes (NHKs) and on a human skin equivalent model. Treatment with β-endorphin reduced inflammatory responses in UVB-irradiated NHKs by inactivating the NF-κB signaling pathway. Additionally, we found that β-endorphin treatment reversed UVB-induced abnormal epidermal proliferation and differentiation in NHKs and, thus, repaired the skin barrier in UVB-treated skin equivalents. The observed effects of β-endorphin on UVB-irradiated NHKs were mediated via blockade of the Akt/mTOR signaling pathway. These results reveal that β-endorphin might be useful against UVB-induced skin injury, including the disruption of the skin barrier function.
Enhanced far infrared emissivity, UV protection and near-infrared shielding of polypropylene composites via incorporation of natural mineral for functional fabric development
Authors: He Pengfei , Low Rayland Jun Yan , Burns Stephen Francis , Lipik Vitali , Tok Alfred Iing Yoong 
Published: December 2023

AbstractFar infrared radiation in the range of 4–20 µm has been showed to have biological and health benefits to the human body. Therefore, incorporating far-infrared emissivity additives into polymers and/or fabrics hold promise for the development of functional textiles. In this study, we incorporated nine types of natural minerals into polypropylene (PP) film and examined their properties to identify potential candidates for functional textiles and apparels. The addition of 2% mineral powders into PP film increased the far-infrared emissivity (5–14 µm) by 7.65%-14.48%. The improvement in far-infrared emissivity within the range of 5–14 µm, which overlaps with the peak range of human skin radiation at 8–14 µm, results in increased absorption efficiency, and have the potential to enhance thermal and biological effects. Moreover, the incorporation of mineral powders in PP films exhibited favorable ultraviolet (UV) protection and near-infrared (NIR) shielding properties. Two films, specifically those containing red ochre and hematite, demonstrated excellent UV protection with a UPF rating of 50+ and blocked 99.92% and 98.73% of UV radiation, respectively. Additionally, they showed 95.2% and 93.2% NIR shielding properties, compared to 54.1% NIR shielding properties of PP blank films. The UV protection and NIR shielding properties offered additional advantages for the utilization of polymer composite with additives in the development of sportswear and other outdoor garments. The incorporation of minerals could absorb near-IR radiation and re-emit them at longer wavelength in the mid-IR region. Furthermore, the incorporation of minerals significantly improved the heat retention of PP films under same heat radiation treatment. Notably, films with red ochre and hematite exhibited a dramatic temperature increase, reaching 2.5 and 3.2 times the temperature increase of PP films under same heat radiation treatment, respectively (46.8 °C and 59.9 °C higher than the temperature increase of 20.9 °C in the PP film). Films with additives also demonstrated lower thermal effusivity than PP blank films, indicating superior heat insulation properties. Therefore, polypropylene films with mineral additives, particularly those containing red ochre and hematite, showed remarkable heat capacity, UV-protection, NIR-shielding properties and enhanced far infrared emissivity, making them promising candidates for the development of functional textiles.
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition
Authors: Lai Xianning , Lui Sarah Kit Leng , Lam Hiu Yan , Adachi Yuta , Sim Wen Jing , Vasilevski Natali , Armstrong Nicola J. , Bridgeman Stephanie Claire , Main Nathan Michael , Tan Tuan Zea , Tirnitz-Parker Janina E. E. , Thiery Jean Paul , Ebi Hiromichi , Kumar Alan Prem , Eichhorn Pieter Johan Adam 
Published: December 2023

AbstractDespite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic window. Like with all MAPK pathway inhibitors, this is likely the result of compensatory pathway activation mechanisms. However, the underlying mechanisms of resistance to SHP2 inhibition remain unknown. The E3 ligase SMURF2 limits TGFβ activity by ubiquitinating and targeting the TGFβ receptor for proteosome degradation. Using a functional RNAi screen targeting all known phosphatases, we identify that the tyrosine phosphatase SHP2 is a critical regulator of TGFβ activity. Specifically, SHP2 dephosphorylates two key residues on SMURF2, resulting in activation of the enzyme. Conversely, SHP2 depletion maintains SMURF2 in an inactive state, resulting in the maintenance of TGFβ activity. Furthermore, we demonstrate that depleting SHP2 has significant implications on TGFβ-mediated migration, senescence, and cell survival. These effects can be overcome through the use of TGFβ-targeted therapies. Consequently, our findings provide a rationale for combining SHP2 and TGFβ inhibitors to enhance tumour responses leading to improved patient outcomes.
Challenges and prospects of visual contactless physiological monitoring in clinical study
Authors: Huang Bin , Hu Shen , Liu Zimeng , Lin Chun-Liang , Su Junfeng , Zhao Changchen , Wang Li , Wang Wenjin 
Published: December 2023

AbstractThe monitoring of physiological parameters is a crucial topic in promoting human health and an indispensable approach for assessing physiological status and diagnosing diseases. Particularly, it holds significant value for patients who require long-term monitoring or with underlying cardiovascular disease. To this end, Visual Contactless Physiological Monitoring (VCPM) is capable of using videos recorded by a consumer camera to monitor blood volume pulse (BVP) signal, heart rate (HR), respiratory rate (RR), oxygen saturation (SpO2) and blood pressure (BP). Recently, deep learning-based pipelines have attracted numerous scholars and achieved unprecedented development. Although VCPM is still an emerging digital medical technology and presents many challenges and opportunities, it has the potential to revolutionize clinical medicine, digital health, telemedicine as well as other areas. The VCPM technology presents a viable solution that can be integrated into these systems for measuring vital parameters during video consultation, owing to its merits of contactless measurement, cost-effectiveness, user-friendly passive monitoring and the sole requirement of an off-the-shelf camera. In fact, the studies of VCPM technologies have been rocketing recently, particularly AI-based approaches, but few are employed in clinical settings. Here we provide a comprehensive overview of the applications, challenges, and prospects of VCPM from the perspective of clinical settings and AI technologies for the first time. The thorough exploration and analysis of clinical scenarios will provide profound guidance for the research and development of VCPM technologies in clinical settings.
A sociotechnical framework to assess patient-facing eHealth tools: results of a modified Delphi process
Authors: Jacob Christine , Lindeque Johan , Müller Roman , Klein Alexander , Metcalfe Thomas , Connolly Samantha L. , Koerber Florian , Maguire Roma , Denis Fabrice , Heuss Sabina C. , Peter Marc K. 
Published: December 2023

AbstractAmong the thousands of eHealth tools available, the vast majority do not get past pilot phases because they cannot prove value, and only a few have been systematically assessed. Although multiple eHealth assessment frameworks have been developed, these efforts face multiple challenges. This study aimed to address some of these challenges by validating and refining an initial list of 55 assessment criteria based on previous frameworks through a two-round modified Delphi process with in-between rounds of interviews. The expert panel (n = 57) included participants from 18 countries and 9 concerned parties. A consensus was reached on 46 criteria that were classified into foundational and contextual criteria. The 36 foundational criteria focus on evaluating the eHealth tool itself and were grouped into nine clusters: technical aspects, clinical utility and safety, usability and human centricity, functionality, content, data management, endorsement, maintenance, and developer. The 10 contextual criteria focus on evaluating the factors that vary depending on the context the tool is being evaluated for and were grouped into seven clusters: data-protection compliance, safety regulatory compliance, interoperability and data integration, cultural requirements, affordability, cost-benefit, and implementability. The classification of criteria into foundational and contextual helps us assess not only the quality of an isolated tool, but also its potential fit in a specific setting. Criteria subscales may be particularly relevant when determining the strengths and weaknesses of the tool being evaluated. This granularity enables different concerned parties to make informed decisions about which tools to consider according to their specific needs and priorities.
Irrigation intensification impacts sustainability of streamflow in the Western United States
Authors: Ketchum David , Hoylman Zachary H. , Huntington Justin , Brinkerhoff Douglas , Jencso Kelsey G. 
Published: December 2023

AbstractQuantifying the interconnected impacts of climate change and irrigation on surface water flows is critical for the proactive management of our water resources and the ecosystem services they provide. Changes in streamflow across the Western U.S. have generally been attributed to an aridifying climate, but in many basins flows can also be highly impacted by irrigation. We developed a 35-year dataset consisting of streamflow, climate, irrigated area, and crop water use to quantify the effects of both climate change and irrigation water use on streamflow across 221 basins in the Colorado, Columbia, and Missouri River systems. We demonstrate that flows have been altered beyond observed climate-related changes and that many of these changes are attributable to irrigation. Further, our results indicate that increases in irrigation water use have occurred over much of the study area, a finding that contradicts government-reported irrigation statistics. Increases in crop consumption have enhanced fall and winter flows in some portions of the Upper Missouri and northern Columbia River basins, and have exacerbated climate change-induced flow declines in parts of the Colorado basin. We classify each basin’s water resources sustainability in terms of flow and irrigation trends and link irrigation-induced flow changes to irrigation infrastructure modernization and differences in basin physiographic setting. These results provide a basis for determining where modern irrigation systems benefit basin water supply, and where less efficient systems contribute to return flows and relieve ecological stress.
Harnessing the Conformer/Atropisomer-Dependent Photochromism of Diarylethene Photoswitches and Forcing a Diarylethene Atropisomer to Its Configurational Diastereomers with Polymer Mechanochemistry
Authors: Hu Xiaoran , Zhang Cijun , Fu Xuancheng 
Published: December 2023

AbstractDiarylethenes are an important class of photoswitches that usually exist in interconvertible parallel (photoinert) and antiparallel (photochromic) conformational states. Recent research afforded sterically congested diarylethenes that exist as stable and separable configurational atropisomers. Rational manipulation of stereochemistry is a robust strategy for regulating diarylethene photochemistry. Here, we present a brief account of the conformer/atropisomer-dependent photochromism of diarylethene photoswitches, and we discuss a recent advance at the interface of diarylethene photochemistry and polymer mechanochemistry: our group recently introduced a mechanical approach for converting a parallel diarylbenzothiadiazole into its antiparallel configurational diastereomers, thereby turning on its photochromic reactivity. After mechanical activation, UV light changes the converted diarylethene molecule into a colored ring-closed form by a 6π-electrocyclization reaction that permits the visualization of the mechanical activation event. Besides the fundamentally new mechanism of converting a molecule into its configurational diastereomers through force–stereochemistry coupling, the conversion of atropisomer stereochemistry is a noncovalent process and features high mechanical reactivity in comparison to conventional mechanophores, which require covalent bond scission. This new type of configurational mechanophore holds promise for various applications, such as high-sensitivity stress sensing, lithography, and information storage.1	Diarylethene Conformers and Atropisomers2	Polymer Mechanochemistry and Configurational Mechanophores3	Regulating the Stereochemistry and Reactivity of a Diarylethene Atropisomer with Mechanical Force4	Summary and Future Outlook
Impact of strategic alliance on the innovation of women-owned enterprises in Nigeria
Authors: Anyanwu Ogochukwu Christiana , Oloto Sunday Emeka , Nwokocha Victor Chukwunweike 
Published: December 2023

AbstractWomen-owned enterprises are rapidly expanding across Africa and have significantly contributed to job growth and wealth development. These enterprises, however, find it challenging to pursue innovation, because of their size and their financial base. Women-owned enterprises, however, can access various resources, talents, and techniques through effective strategic alliances. Being in alliance with other market participants allows these enterprises to overcome the hurdles limiting their performance and innovativeness. This research analyses the impact of strategic alliances on the innovation of women-owned enterprises in Nigeria. The study adopts a quantitative survey approach. It selected 109 women-owned enterprises from five manufacturing subsectors in the study area, using a purposive random sample technique. Regression analysis is used to analyze the data, while tables are utilized to show results. The results reveal that different strategic alliance characteristics had different effects on the innovation of women-owned enterprises. The finding in process innovation showed that increased new opportunities and cost reduction led to 0.76 and 0.62 increases in process innovation, respectively. In comparison, an increase in cost reduction led to a 0.63 increase in product innovation in the enterprises. These results signified that strategic alliances enabled women-owned enterprises to achieve product and process innovation. This study recommends that policymakers should encourage the use of strategic alliances by women-owned enterprises. This will allow them to innovate by introducing new products and processes in their enterprises.
Regulation of aggregation-induced emission properties of Ag(0)@Ag(I) rich−thiolate core-shell nanoclusters: Ligand assembly dominated
Authors: Yang Taiqun , Li Lei , Zhou Jiafeng , Shan Bingqian , Gao Hui , Zhu Chun , Chen Guoqing , Zhang Kun 
Published: December 2023

Aggregation-induced emission (AIE) is an effective strategy for improving the photoluminescence (PL) performance of metal nanoclusters (MNCs). However, the origin of AIE in MNCs is still not fully understood, which is pivotal for the design of AIE luminogens (AIEgens). Here, water soluble silver nanoclusters (Ag NCs) with AIE properties were synthesized. These as-synthesized non-luminescent Ag NCs will become photoluminescent when transferred from water to ethanol, and the emission peak was redshifted from ∼560 to ∼600 nm and largely intensified with the addition of Cu2+. The addition of Cu2+ makes a big difference in the PL properties of Ag NCs. That is, the PL will be enhanced if Cu2+ is added with the sequence “Ag NCs + Cu2++EtOH.” In contrast, the PL will be quenched if Cu2+ is added with the sequence “Ag NCs + EtOH + Cu2+.” The PL was from the supramolecular clusters formed by the assembly of capping ligands on the confined surface of individual silver clusters through weak interactions. The addition of Cu2+ could regulate the assembly structure and further affect the energy lever (p-band) through space electron interactions. These results provide new insights into the AIE process in metal nanoclusters.
An in-context overview of legal translator competences, qualifications and other professional requirements set in the
ISO 20771:2020 Legal translation – Requirements standard
Authors: Popiołek Monika 
Published: December 2023

Abstract
This article provides an overview of legal translator competences, qualifications and other professional
requirements set in the ISO 20771:2020 standard. References to existing frameworks,
such as European Qualifications Framework (EQF) and some research, complementary ISO standards (notably ISO 17100:2015) and current industry best-practice offer relevant context and background information, and
identify the gap that has been filled by this important standard.
The author demonstrates that ISO 20771:2020 is a good example of a
requirements standard developed for the translation industry that is up-to-date, reflects actual industry best-practice, and
addresses a need for standardization of legal translator requirements for the purpose of certification. It is posited here that
ISO 20771:2020 is a valuable resource for all stakeholders as it not only provides
accurate information about standard market requirements for legal translation (and translation in general) but also contributes to
translators’ professionalization by setting objective professional benchmarks. Additionally, ISO requirements standards are, by
definition, pragmatic and operational, and therefore easier to validate through conformity assessment and certification than any
other resources, and hence both the industry and academia can only benefit from increased ISO standards uptake.
The overview of legal translator competences, qualifications and other professional requirements set in the ISO 20771:2020 standard reflects the ISO approach to setting translator requirements, and
outlines some of the practical implications of translation industry standardization and certification in the hope that it might
become the starting point for more discussions on this subject in the future.
ISO standards for terminology resources management
Authors: Vezzani Federica , Di Nunzio Giorgio Maria , Costa Rute 
Published: December 2023

Abstract
The ‘FAIR terminology’ paradigm is the first initiative that aims to establish a strong interrelation between the
FAIR (Findability, Accessibility, Interoperability, and
Reusability) principles, promoted at the European level to foster the Open Science movement, and the
specifications advocated in the framework of ISO TC 37/SC 3 about the management of terminology resources. Through the
complementary adoption of the SC 3 standards, the paradigm, therefore, proposes guidelines paving the way for the FAIRification of
terminological data, metadata, and infrastructure. In this context, this study has a threefold objective. First, we will show the
impact of three ISO TC 37/SC 3 standards (mainly ISO 16642: 2017; ISO 12620: 2019 and ISO 30042: 2019) for the foundation of the
FAIR terminology paradigm. Secondly, we will present the integration of this data representation model in the framework of the
European project ‘Terminology Without Borders’ (TWB) launched in 2019 by the Terminology Coordination Unit (TermCoord) of the
European Parliament. Finally, we intend to reflect in a critical perspective to highlight some possible limitations of the
previously mentioned SC 3 standards in terms of FAIRification of terminological data.
The epistemological orientation of Ottoman argumentation theory and its relation to kalām
Authors: Ince Serkan 
Published: December 2023

Abstract
Islamic (Ottoman) argumentation theories provide strong evidence that the argumentation theory advocated by
Ottoman theorists was epistemologically oriented, and has strong parallels with the argumentation theory of kalām
(dialectical theology); indeed Ottoman argumentation theory and kalām interacted intensively and influenced each
other. This article traces some snapshots of this discourse. In doing so, key concepts of Islamic (Ottoman) argumentation theories
are introduced.
Adsorption equilibrium and kinetics studies of crystal violet adsorbed by anionic polymer brush functionalized mesoporous silica nanoparticles
Authors: Alswieleh Abdullah 
Published: December 2023

Abstract
The removal of crystal violet (CV) dye from an aqueous solution has been investigated using anionic poly(potassium 3-sulfopropyl methacrylate) (PKSPMA) brushes grafted on mesoporous silica nanoparticles (MSNPs). Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to characterize PKSPMA brushes modified MSNPs (PKSPMA@MSNPs). Surface-modified MSNPs were almost spherical shapes with sizes ranging between 190 nm and 340 nm with an average pore size of ca. 5. The adsorption process of the CV was investigated under various of testing conditions, including pH, contact duration and initial dye concentration. The maximum loading of CV onto PKSPMA@MSNPs was observed at pH 3, with approximately 91% adsorption efficiency at a concentration of 100 ppm. The removal of CV onto PKSPMA@MSNPs was best described by the Langmuir isotherm, with a maximum monolayer adsorption capacity (qmax) of 128.37 mg g−1. The kinetics of the adsorption process were best described by the pseudo-second-order model.