bluuebunny/crossref_metadata_2025_split huggingface dataset:
Summer heat, historic redlining, and neighborhood walking among older adults: 2017 National Household Travel Survey
Authors: Mitsova Diana , Besser Lilah , Le Elaine Thanh Truc 
Published: February 2024

Abstract

No known studies have examined the relationships between urban heat islands, historic redlining, and neighborhood walking in older adults. We assessed whether: 1) individual and neighborhood characteristics (including redlining score) differ by neighborhood summer land surface temperature (LST); 2) higher LST is associated with less neighborhood walking, and whether associations differ by historic redlining score; and 3) neighborhoods with discriminatory redlining scores have greater LSTs. We used data on 3,982 ≥65-year olds from the 2017 National Household Travel Survey. Multivariable negative binomial and linear regressions tested associations between LST z-score (comparing participant's neighborhood LST to surrounding region's LST) and self-reported neighborhood walking, and the association between living in neighborhoods redlined as "definitely declining" or "hazardous" (versus "still desirable"/"best") and LST z-score. LSTs were higher for those in neighborhoods with higher area deprivation scores and more African American/Black residents. Older adults living in neighborhoods with higher summer LST z-scores had fewer minutes of neighborhood walking/day. This association seemed limited to individuals with neighborhood redlining scores of "still desirable"/"best". Neighborhood redlining scores of "definitely declining" or "hazardous" (versus "still desirable" and "best") were associated with greater neighborhood summer LSTs. Overall, these findings suggest that historically redlined neighborhoods may more often experience urban heat island effects, and older adults living in hotter neighborhoods may less often engage in neighborhood walking. Future work is needed to elucidate the impact of extreme heat on health promoting behaviors such as walking and the types of interventions that can successfully counteract negative impacts to historically disadvantaged communities.
Harnessing the potential of zinc oxide nanoparticles from Strychnos potatorum seeds impregnated with activated carbon for an effective removal of fluoride in deep soil water
Authors: V. Akshaya , G. Jayanthi 
Published: February 2024

Abstract

Fluoride (F−) contamination in global water sources is a growing concern, prompting the need for innovative solutions. This explores a novel method using zinc oxide nanoparticle-activated carbon (ZnO-NP/AC) composite for efficient fluoride removal from deep soil water, aiming to evaluate its effectiveness in attracting fluoride contaminants. The focus is on treatment of water sample collected from Dharmapuri, Tamil Nadu, using green synthesis method for ZnO-NP/AC column filter. Employed an exclusive column adsorption method, investigated on physiochemical parameters in water before and after running the column. Fluoride concentration and TDS where significantly harnessed in water after running the green synthesis composite column filter. Characterization of green synthesized nanoparticles of Strychnos potatorum seed powder synthesis with ZnO NPs. Green synthesis successes were confirmed in two ways; one way is UV-visible spectrophotometer technique in depth quantity peak and another one is graphically peak from SEM, density and crystalline structure in XRD techniques. Column composite with S.potatorum ZnO-AC NPs has removed fluoride efficiently (80.5%) at range of 20 g/L for a contact time of 60 minutes, surpassing World health organization (WHO) guidelines for safe drinking water. In conclusion ZnO-AC NPs composite is a sustainable and cost-effective method for effective removal of fluoride contaminants from deep soil water, addressing a pressing global issue.
Modeling flow of the major canals of Sylhet city using the EPA SWMM runoff model
Authors: Munna Gulam Md , Hasan Md Mahmudul , Alam Md Jahir Bin , Uddin Md Misbah , Rahman Mohammad Shahidur , Nury Ahmad Hasan , Islam Shriful 
Published: February 2024

Abstract

Geographically, local canals in Sylhet city, Bangladesh, mostly transport the rainwater to the Surma River as the city lacks typical drainage infrastructure for runoff control. Hence, proper hydraulic and hydrologic models are required to assess the current potential of these canals to withstand significant runoff and enhance the protection of flood problems during a severe storm. In this study, Malni Chara and Goali Chara sub-systems of Sylhet city's major drainage networks were calibrated and verified using the EPA Storm Water Management Model (SWMM), respectively, using the hydrological data from 2016 to 2019 and the meteorological data from 1975 to 2019. The models were suitable for measuring the runoff quantity since the simulated results matched the observed data well. For the Malni Chara sub-system, R2 of 0.94, Nash–Sutcliffe efficiency (NSE) of 0.92, d of 0.97, percent bias (PBIAS) (%) of 2.96%, and RMSE standard deviation ratio (RSR) of 0.05 have been found and for the Goali Chara sub-system, R2 of 0.96, NSE of 0.90, d of 0.93, PBIAS (%) of 1.54%, and RSR of 0.08 have been found.
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene
Expression Changes in Multiple Organ Dysfunctions During Wound
Healing Process in Rats
Authors: Bozkurt Ahmet Sarper , Yılmaz Şenay Görücü 
Published: February 2024

Background:
Injury systemically disrupts the homeostatic balance and can cause organ
failure. LF mediates both iron-dependent and iron-independent mechanisms, and the role of LF in
regulating iron homeostasis is vital in terms of metabolism.

Objectives:
In this study, we evaluated the organ-level effect and gene expression change of bLf
in the cutaneous repair process.

Materials and Methods:
An excisional full-thickness skin defect (FTSD) wound model was created
in male Sprague Dawley rats (180-250 g) (n = 48) fed a high-fat diet (HFD) and the PHGPx,
SLC7A11 and SLC40A1 genes and iron metabolism were evaluated. The animals were randomly
divided into 6 groups: 1- Control, 2- bLf (200 mg/kg/day, oral), 3- FTSD (12 mm in diameter, dorsal),
4- HFD + bLf, 5- HFD + FTSD, 6- HFD + FTSD + bLf. Histologically, iron accumulation
was demonstrated by Prussian blue staining in the liver, kidney, and intestinal tissues. Gene expression
analysis was performed with qPCR.

Results:
Histologically, iron accumulation was demonstrated by Prussian blue staining in the liver,
kidney, and intestinal tissues. Prussian blue reactions were detected in the kidney. PHPGx and
SLC7A11 genes in kidney and liver tissue were statistically significant (P < 0.05) except for the
SLC40A1 gene (P > 0.05). Expression changes of the three genes were not statistically significant
in analyses of rat intestinal tissue (P = 0.057).

Conclusion:
In the organ-level ferroptotic damage mechanism triggered by wound formation. BLf
controls the expression of three genes and manages iron deposition in these three tissues. In addition,
it suppressed the increase in iron that would drive the cell to ferroptosis and anemia caused
by inflammation, thereby eliminating iron deposition in the tissues.
Repurposing of Plant-based Antiviral Molecules for the Treatment of
COVID-19
Authors: Khazir Jabeena , Ahmed Sajad , Thakur Rakesh Kr , Hussain Manzoor , Gandhi Sumit G. , Babbar Sadhana , Mir Shabir Ahmad , Shafi Nusrat , Tonfack Libert Brice , Rajpal Vijay Rani , Maqbool Tariq , Mir Bilal Ahmad , Peer Latif Ahmad 
Published: February 2024

Abstract:
COVID-19, stemming from SARS-CoV-2, poses a formidable threat to global healthcare, with a staggering 77 million confirmed cases and 690,067 deaths recorded till Decem-ber 24, 2023. Given the absence of specific drugs for this viral infection, the exploration of novel antiviral compounds becomes imperative. High-throughput technologies are actively engaged in drug discovery, and there is a parallel effort to repurpose plant-based molecules with established antiviral properties. In this context, the review meticulously delves into the potential of plant-based folk remedies and existing molecules. These substances have showcased substantial viral inhibition in diverse in vivo, in silico, and in vitro studies, particularly against critical viral protein targets, including SARS-CoV-2. The findings position these plant-based molecules as promising antiviral drug candidates for the swift advancement of treatments for COVID-19. It is noteworthy that the inherent attributes of these plant-based molecules, such as their natural origin, potency, safety, and cost-effectiveness, contribute to their appeal as lead candidates. The review advocates for further exploration through comprehensive in vivo studies conducted on animal models, em-phasizing the potential of plant-based compounds to help in the ongoing quest to develop effec-tive antivirals against COVID-19.
IMPDH2 Positively Impacts the Proliferation Potential of Hepatoblastoma Cells
by Activating JunB Signaling Pathway
Authors: Yuan Li , Zeng Liang , Ye Feng , Chen Kai , Chen Zhengrong , Li Liping 
Published: February 2024

Background::
Amplification of inosine monophosphate dehydrogenase II, EC 1,1,1,205 (IMPDH2) has been reported in various cancers, which results in
transformation and tumorigenicity. In our current work, we have explored the oncogenic properties and the underlying pathophysiology of
IMPDH2 in hepatoblastoma (HB).

Methods::
To investigate IMPDH2 expression in HB tissues and prognostic significance in HB patients, gene expression profiling interactive analysis
(GEPIA) has been adopted. Immunohistochemistry has also helped to validate the protein expression of IMPDH2 in HB tissues. The effect of
IMPDH2 overexpression or depletion on the proliferation of Hepatoblastoma cells in vitro has been evaluated by CCK8 assays and colony
formation assays. Xenograft tumor growth of mice has been detected. Luciferase reporter assays have been conducted to determine the interaction
of IMPDH2 and JunB, which was further asserted by pharmacological inhibition of JunB.

Results::
IMPDH2 was highly expressed in HB tissues. Experimentally, the proliferation and colony formation of HuH6 cells were increased by IMPDH2
overexpression. Conversely, genetic inactivation of IMPDH2 impaired the proliferative efficiency and colony-forming rate of HepG2 cells.
Besides, the luciferase reporter assay validated IMPDH2 overexpression to be associated with enhanced JunB transcriptional activity, while its
activity was diminished in the case of IMPDH2 depletion. JunB inhibitor neutralized the IMPDH2-mediated increased phosphorylation of JunB.

Conclusion::
Our findings, thus, suggest that IMPDH2 exhibits its oncogenic role in HB partially via JunB-dependent proliferation.
Emergent Endovascular Treatment of Iatrogenous Pseudoaneurysms of the
Neck Following Jugular Catheterization
Authors: Deniz Sinan , Abaci Gizem 
Published: February 2024

Introduction::
Inadvertent puncture of the adjacent structures during a central venous catheterization is a well-known complication which may be managed conservatively when the injury is self-limiting, but requires a further treatment when there’s a proof of an active bleeding and/or a growing hematoma.

Case Representation:
We report a case of a 57-year-old bone-marrow-transplant patient with neck hematoma and bleeding followed by a non-sonographic-guided central venous line placement. CT showed a right sided hematoma in the neck region with a midline shift of the airway. The patient was under prophylactic LMWH. Emergent angiography demonstrated three different bleeding sites which were successfully embolized with coil and liquid embolic agents by endovascular means.

Conclusion:
Interventional radiology offers a quick and safe approach in the management of potentially life-threatening bleeding complications.
Capturing the Dynamics of Homelessness Through Ethnography and Mobile Technology: Protocol for the Development and Testing of a Smartphone Technology–Supported Intervention
Authors: Foster Marva , Fix Gemmae M , Hyde Justeen , Dunlap Shawn , Byrne Thomas H , Sugie Naomi F , Kuhn Randall , Gabrielian Sonya , Roncarati Jill S , Zhao Shibei , McInnes D Keith 
Published: February 2024

Background
US military veterans who have experienced homelessness often have high rates of housing transition. Disruptions caused by these transitions likely exacerbate this population’s health problems and interfere with access to care and treatment engagement. Individuals experiencing homelessness increasingly use smartphones, contributing to improved access to medical and social services. Few studies have used smartphones as a data collection tool to systematically collect information about the daily life events that precede and contribute to housing transitions, in-the-moment emotions, behaviors, geographic movements, and perceived social support.

Objective
The study aims to develop and test a smartphone app to collect longitudinal data from veterans experiencing homelessness (VEH) and to evaluate the feasibility and acceptability of using the app in a population that is unstably housed or homeless.

Methods
This study’s design had 3 phases. Phase 1 used ethnographic methods to capture detailed data on day-to-day lived experiences of up to 30 VEH on topics such as housing stability, health, and health behaviors. Phase 2 involved focus groups and usability testing to develop and refine mobile phone data collection methods. Phase 3 piloted the smartphone mobile data collection with 30 VEH. We included mobile ethnography, real-time surveys through an app, and the collection of GPS data in phase 3.

Results
The project was launched in June 2020, and at this point, some data collection and analysis for phases 1 and 2 are complete. This project is currently in progress.

Conclusions
This multiphase study will provide rich data on the context and immediate events leading to housing transitions among VEH. This study will ensure the development of a smartphone app that will match the actual needs of VEH by involving them in the design process from the beginning. Finally, this study will offer important insights into how best to develop a smartphone app that can help intervene among VEH to reduce housing transitions.

International Registered Report Identifier (IRRID)
DERR1-10.2196/53022
Community-Dwelling Older Adults’ Readiness for Adopting Digital Health Technologies: Cross-Sectional Survey Study
Authors: Ausserhofer Dietmar , Piccoliori Giuliano , Engl Adolf , Mahlknecht Angelika , Plagg Barbara , Barbieri Verena , Colletti Nicoletta , Lombardo Stefano , Gärtner Timon , Tappeiner Waltraud , Wieser Heike , Wiedermann Christian Josef 
Published: February 2024

Background
Digital health technologies offer the potential to improve the daily lives of older adults, maintain their health efficiently, and allow aging in place. Despite increasing evidence of benefits and advantages, readiness for adopting digital interventions among older people remains underexplored.

Objective
This study aims to explore the relationships between sociodemographic-, health-, and lifestyle-related factors and technology use in everyday life and community-dwelling older adults’ readiness to adopt telemedicine, smartphones with texting apps, wearables, and robotics.

Methods
This was a cross-sectional, population-based survey study with a stratified probabilistic sample of adults aged 75 years or older living in South Tyrol (autonomous province of Bolzano/Bozen, Italy). A random sample of 3600 community-dwelling older adults living at home was invited to complete a questionnaire including single items (older adults’ readiness to use health technology) and scales (PRISMA-7; Program of Research on Integration of Services for the Maintenance of Autonomy). Descriptive and logistic regression analyses were performed to analyze the data.

Results
In total, 1695 community-dwelling older adults completed the survey (for a response rate of 47%). In terms of potential digital health technology adoption, wearable devices were favored by 33.7% (n=571), telemedicine by 30.1% (n=510), smartphones and texting apps by 24.5% (n=416), and assistant robots by 13.7% (n=232). Sociodemographic-, health- and lifestyle-related factors, as well as the use of technology in everyday life, played a significant role in explaining readiness to adopt digital health technologies. For telemedicine, age ≥85 years (odds ratio [OR] 0.74, 95% CI 0.56-0.96), financial constraints (OR 0.68, 95% CI 0.49-0.95), and less than 2 hours of physical activity per week (OR 0.75, 95% CI 0.58-0.98) were associated with nonreadiness, while Italian-speaking participants (OR 1.54, 95% CI 1.16-2.05) and those regularly using computers (OR 1.74, 95% CI 1.16-2.60), smartphones (OR 1.69, 95% CI 1.22-2.35), and the internet (OR 2.26, 95% CI 1.47-3.49) reported readiness for adoption.

Conclusions
Community-dwelling older adults display varied readiness toward the adoption of digital health technologies, influenced by age, mother tongue, living situation, financial resources, physical activity, and current use of technology. The findings underscore the need for tailored interventions and educational programs to boost digital health technology adoption among community-dwelling older adults.
Factors Affecting Audit Quality In Internal Auditors
Authors: Pangestu Siam , Hidayah Yuniarti 
Published: February 2024

Purpose: This study aims to analyze the influence of competence, independence, objectivity, ethical sensitivity, and experience of auditors on the quality of audit results at the Tulungagung Regency Inspectorate.
Methodology/approach: This research uses a quantitative methods using questionnaires distributed to auditors and P2UPD at the Tulungagung Regency Inspectorate. Data were analysed using a statistical application SmartPLS 3.
Findings: The results show, that independence, ethical sensitivity, and auditor experience significantly affect the quality of audit results. Meanwhile, competence and objectivity do not significantly affect the quality of audit results.
Practical and Theoretical contribution/Originality: Currently, the Tulungagung Regency Inspectorate was asked to conduct a re-audit because it was known that the results of previous audits differed from field data or facts obtained by the Tulungagung District Attorney team.
Research Limitation: This study was only conducted at the Tulungagung Regency Inspectorate. So that the respondents were limited to 33 examining staff or auditors and P2UPD in the Tulungagung Regency Inspectorate
The role of exogenous glutamine on germination, plant development and transcriptional expression of some stress-related genes in onion under salt stress
Authors: Ulukapi Kamile , Nasircilar Ayse Gul 
Published: February 2024

ABSTRACT
The purpose of this research was to explore the role of glutamine (Gln) on plant germination and growth under salinity [0, 50, 100, 150, 200 mM sodium chloride (NaCl)], and on the activation of some stress-related genes [CuZn-Superoxide Dismutase (SOD), Mn-SOD, L-ascorbate oxidase (AO), DNA Polymerase Delta 1 (POLD)-1, Chaperon (CHAPE) and Heat Shock Protein (HSP)-21], genetic template stability and photosynthetic pigment activation. Under salt stress, 2 mM Gln application reduced the mean germination time (MGT) (4.51 days), increased the coefficient of velocity of germination (CVG) (75.85), germination index (GI) (1.46) and germination percentage (GP) (82%), indicating that it was the best application for germination under stress. Gln promoted the development of aboveground plant organs. 3 mM Gln increased the number of leaves from 5.3 to 13.7 and 4.3 to 6.6 under unstress and stress conditions, respectively. Under salt stress, Gln increased photosynthetic pigments and genomic template stability (GTS) (80%). At 2 mM Gln, total chlorophyll and carotenoid content increased from 1.59 mg · g-1 TA to 2.23 mg · g-1 TA and from 0.28 mg · g-1 TA to 0.37 mg · g-1 TA, respectively. The effect on gene expression levels varied with the concentration. The application of 2 mM Gln, which enhanced germination and vegetative parameters under stress, caused a raise in CuZn-SOD gene expression and a 43% decrease in the transcriptional expression of the HSP-21 gene as an indicator of the functionality of the repair mechanism. The improved growth of Gln-treated plants under stress suggests that Gln is involved in bridging the energy deficit of the plant by acting as an alternative fuel for metabolic activities under stress.
Practitioners’ Professional Development Needs From a Sustainability Perspective: The Impact of Some Demographic Features
Authors: Okeke Chinedu Ifedi , Mudzielwana Ndileleni P. , Mokhele-Makgalwa Matseliso 
Published: February 2024

Abstract
Professional development for sustainability in early childhood care and education (ECCE) has been perceived by experts as education that supports the workforce to acquire the right skills, attitudes, and knowledge that resonate through their practices to the benefit of the sector. Professional development for sustainability is aimed at providing quality and continuing development to the ECCE workforce to equip them with the relevant skills to perform their duties for the benefit of the children and society. This paper discusses practitioners’ (n=211) professional development needs from a sustainability perspective and the impacts of some demographic features. The data were gathered through semi-structured interviews and questionnaire. The study found that practitioners’ professional development was germane to the sustainability of the ECCE sector. The study further found that practitioners’ perceptions of their professional development needs were independent of their marital status and age. Practitioners suggested that the transformation of communities depended on the sustainable provisioning of ECCE by a highly trained workforce.
Fabrication of biomimetic anisotropic crescent-shaped microstructured surfaces by laser shock imprinting
Authors: Ji Jie , Meng Kangnan , Li Pin , Shen Zongbao 
Published: February 2024

Abstract
The crescent-shaped microstructure bionic to the slip zone of the slippery zone of the carnivorous plant genus Nepenthes was fabricated on the surface of copper foil by laser shock imprinting (LSI). The microstructure of crescent-shaped grooves was initially fabricated on the surface of the micro-mold by etching, and then the microstructure was replicated on the surface of copper foil through plastic deformation under laser shock loading. Increasing the laser shock energy or the number of shocks can increase the degree of replication of the crescent-shaped microstructure, the height of the crescent-shaped microstructure, and the contact angle of water droplets on the surface. The wettability of the surface of the crescent microstructure is anisotropic and increases with an increase in offset distance. The anisotropy of the crescent-shaped microstructure causes the solid–liquid contact line in the direction of the bottom of the arc to become a long and approximately straight line. According to the rule that controlling LSI processing parameters can fabricate surfaces with different heights and wettability, a gradient wetting surface consisting of crescent-shaped microstructures was designed to achieve the directional spreading of droplets. By altering the distribution of crescent-shaped microstructures, a type-I flow channel with the ability to limit the spreading range of water droplets was fabricated.