bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote sensing in the leaf spectral characterization of the Hesperozygis ringens, an endangered species
Authors: Pinheiro Carlos Garrido , Mallmann Caroline Lorenci , Pereira Filho Waterloo , Heinzmann Berta Maria 
Published: February 2025

Hesperozygis ringens is a species that stands out for the production of essential oil. No reports on the leaf spectral characterization of the species have been found. This study aimed to determine the reflectance pattern of Hesperozygis ringens leaves with the aid of Remote Sensing. Therefore, a spectroradiometer that operates in the continuous spectral range from 400 to 900 nm of the electromagnetic spectrum was used, with a resampled precision of 1 nm. The reflectance measurement was collected in situ. Four records were obtained. A spectral curve was created from the means of measurements in each sample. In the blue region, reflectance values between 0.0116696 and 0.0399550 were found. In the red region, the reflectance oscillated between 0.0438487 and 0.1095826. In the green region, the reflectance values ranged between 0.0405677 and 0.1001319. In the near-infrared region, the oscillation of reflectance values occurred between 0.1163483 and 0.4655269. The results indicate the effectiveness of the use of geotechnologies to carry out the spectral characterization of the H. ringens leaf. Further studies are expected to identify and monitor plant populations with Remote Sensing.
ESTABLISHMENT AND GROWTH OF LIPPIA GRACILIS SCHAUER CULTIVATED UNDER DIFFERENT IN VITRO CONDITIONS
Authors: Lazzarini Luiz Eduardo Santos , Pacheco Fernanda Ventorim , Santiago Alexsandro Carvalho , Coelho Adriane Duarte , Bertolucci Suzan Kelly Vilela , Pinto José Eduardo Brasil Pereira 
Published: February 2025

The objective of this study was to evaluate the explant type, its position and the culture medium used for the establishment and in vitro culture of Lippia gracilis. For the establishment experiment, the treatments were: two types of explants (apical and nodal) taken from two cultivation environments (field and greenhouse), and inoculated in two types of culture medium (MS and MS/2). Half of the salt concentration and the use of explants from a greenhouse reduced the rates of contamination, oxidation, and necrosis in the in vitro establishment of Lippia gracilis. In order to verify the influence of the explant position, the treatments consisted of explants horizontally or vertically inoculated. For the evaluation of sucrose in the culture medium, the concentrations of 7.5; 15; 30 and 60 g L-1 were tested, while for salt concentration, the treatments consisted of 4 different salt concentrations: ¼ MS; ½ MS; MS and 2MS. The sucrose concentration of 30 g L-1 and ½ MS culture medium showed the best growth results for the species. Although the production of dry matter was reduced in this concentration of salts, the plantlets were more vigorous to proceed to acclimatization. Therefore, the inoculation of explants in a horizontal position in ½ MS culture medium, supplemented with 30 g L-1 of sucrose is recommended for in vitro cultivation of L. gracilis.
Keywords: Carbohydrates, culture medium, micropropagation, salts, tissue culture.
Strengthening Environmental Awareness in Children Through Drawing Activities
Authors: Jasjfi Elda Franzia , Rianingrum Cama Juli , Iskandar Layla Nurina Kartika , Wiana Amanda , Hidayatullah Ahmad Syarif 
Published: February 2025

Pondok Yatim and Dhuafa Tomang are located on Jl. Gelong Baru No. 8, Tomang Village, Grogol Petamburan District, West Jakarta, is inhabited by 10 children aged 3-12 years. Currently, no special environmental awareness or art activities are carried out by the children at Pondok Yatim and Dhuafa Tomang. Even though they are interested in the environment and have free time to carry out various activities after formal school ends, one of which is drawing. For this reason, drawing training activities are carried out to increase awareness of the environment through Community Service activities by the Faculty of Art and Design, Universitas Trisakti. This activity aims to help the children Pondok Yatim and Dhuafa Tomang foster. The activity targets are gaining knowledge about the environment, developing drawing skills, and developing creativity. The training was carried out using the participatory action research (PAR) method to obtain primary information from the target audience and to participate actively in implementing the training. The training results are children's drawings on environmental themes with various creative objects and interactions with the surrounding environment as a reflection of the environmental concerns of the children assisted by Pondok Yatim and Dhuafa Tomang. The training activities were carried out well according to the objectives of the training activities.
Training on Making Simple Basic Fish Feed to Improve the Skills of Fish Farmers Milkfish
Authors: Kasi Yohanes Freadyanus , Lena Fransiskus Jenga , Sode Anastasia 
Published: February 2025

The people of Aeramo village, Nagekeo Regency, who work as fish farmers, find it very difficult to provide fish feed due to the high feed price. The purpose of implementing this community service activity is to provide information about the process of making simple-based fish feed and their response. Community service was carried out in June 2023 in Dusun II, Aeramo Village, Nagekeo Regency. The activity method is Asset Based Community Development (ABCD), which aims to carry out community service based on the strengths and potential of the community. Discussions and interviews, counseling, and direct practice carried out data collection. The results obtained from this fish feed-making training activity are: 1) the community knows that the actual feed they buy so far ingredients are around them and are very simple, 2) the community is able to absorb the knowledge gained about how to make feed starting with the preparation of tools and materials, making formulations, to making feed and given directly to cultured fish. Fish farmers can easily make fish feed, and the raw materials used in making feed can be obtained in the surrounding area, making it easier for farmers to make their feed.
Angka Autopsi Di RSUP Dr. Sardjito Selama Satu Dekade Terakhir
Authors: Wiguna Gusti Ngurah Bagus Prenama , Basworo Wikan 
Published: February 2025

Pendahuluan: Walaupun berbeda konvesi medis dan aturan hukum dari masing-masing negara, secara umum terdapat 2 tipe autopsi, yaitu autopsi klinis dan autopsi medikolegal/autopsi forensik. Secara global terjadi penurunan jumlah otopsi di seluruh dunia dalam beberapa dekade terakhir. Di Indonesia data terkait hal ini cukup sedikit. Berdasarkan penelitian yang dilakukan oleh Henky dkk. pada tahun 2016 didapatkan hasil bawah terjadi penurunan jumlah autopsi di RSUP Sanglah dalam 5 tahun terakhir. Berdasarkan fenomena ini peneliti juga ingin mengetahui terkait dengan angka autopsi di RSUP Dr. Sardjito serta menganalisi terkait apa saja kemungkinan yang menyebabkan terjadinya penurunan angka autopsi ini.
Tujuan: Menggambarkan angka autopsi di RSUP Dr. Sardjito, untuk memberikan gambaran secara umum terkait dengan adanya trend penurunan autopsi di seluruh dunia dalam beberapa dekade terakhir. Serta menganalisis faktor-faktor yang mungkin berperan terhadap angka pelaksanan autopsi.
Metode: Penelitian ini bersifat deskriptif cross sectional / potong lintang yang di lakukan di Instalasi Kedokteran Forensik, RSUP dr. Sardjito Yogyakarta dari tahun 2014 hingga 2023. Kasus kematian tidak wajar yang dilakukan pemeriksaan luar dan dalam di RSUP Dr. Sardjito dikumpulkan menggunakan data sekunder dari registrasi pemeriksaan jenazah. Kemudian data tersebut diolah dalam bentuk grafik dan narasi.
Hasil: Semua kasus kematian tidak wajar yang dikirim ke Instalasi Kedokteran Forensik dan Medikolegal RSUP Dr. Sardjito mengalami penurunan setiap tahunnya, kasus terbanyak yaitu pada tahun 2015 sebanyak 147 kasus dan paling rendah pada tahun 2021 dengan jumlah 20 kasus. Seluruh kasus yang masuk dilakukan pemeriksaan luar, jumlah pemeriksaan luar terbanyak yaitu 147 kasus pada tahun 2015 dan yang terendah yaitu 20 kasus pada tahun 2020. Autopsi juga mengalami hal yang sama yaitu persentasenya menurun dari 23% pada tahun 2014 menjadi 7% pada tahun 2023.
Kesimpulan: Jumlah kasus pemeriksaan luar dan autopsi mengalami penurunan dalam satu dekade terkahir. Tindakan autopsi dari 23% pada tahun 2014 menjadi 7% pada tahun 2023. Beberapa faktor yang mempengaruhi fenomena ini diantaranya kurang pengetahuan terkait autopsi, tidak mendapatkan izin dari keluarga, dan proses autopsi dianggap menghabat proses pemakaman.
Kata Kunci: Penurunan, Autopsi, Kedokteran Forensik
Frustrated S = 1/2 Chains in One-Dimensional Correlated Metal Ti4MnBi2
Authors: Li Xiyang , Nocera Alberto , Foyevtsova Kateryna , Sawatzky George , Oudah Mohamed , Murai Naoki , Kofu Maiko , MATSUURA Masato , Tamatsukuri Hiromu , Aronson Meigan 
Published: February 2025

Abstract

Electronic correlations lead to heavy quasiparticles in three-dimensional (3D) metals, and their collapse can destabilize magnetic moments. It is an open question whether there is an analogous instability in one-dimensional (1D) systems, unanswered due to the lack of metallic spin chain materials. We report neutron scattering measurements and Density Matrix Renormalization Group calculations establishing spinons in the correlated metal Ti4MnBi2, confirming that its magnetism is 1D. Ti4MnBi2 is inherently frustrated, forming near a quantum critical point (QCP) separating different temperature T = 0 phases of the J1-J2 XXZ model. 1D magnetism dominates to the lowest T, and is barely affected by weak interchain coupling. Ti4MnBi2 is the first metallic spin chain where 3D conduction electrons become strongly correlated due to their coupling to 1D magnetic moments.
Association of Placental Pathology and antibiotic exposure after birth with the Severity of Necrotizing Enterocolitis in Preterm infants - A Matched Case-Control Study
Authors: Garg Parvesh Mohan , Riddick Robin , Ansari Md Abu Yusuf , rebentisch Aubrey , Shetty Avinash , Adams Kristin , Hillegass William B. , Garg Padma 
Published: February 2025

Abstract

Objective: To determine the association between antibiotic exposure following birth and necrotizing enterocolitis (NEC) severity in preterm infants.
Methods:This single center matched case-control study included infants with NEC (n=107) and matched controls (n= 130) with antibiotic exposure =< 3 days and > 3 days after birth.
Results: Out of 212 infants,103 infants (48.5%) received antibiotics =< 3 days, and 109 infants (51.5%) received antibiotics >3 days. On the multivariate regression, Infants receiving antibiotics for >3 day had higher risk for medical NEC (aOR 2.61,95% CI 1.35 -5.16; p=0.005) and surgical NEC (aOR 3.33, CI 1.57-7.40; p=0.02) than controls. In NEC cohort, those receiving antibiotics for >3 days were like to die (OR 7.88,95% CI 1.99- 53.74; p=0.010) than those receiving antibiotics <3 days.
Conclusion: Infants exposed with early antibiotics >3 days after birth were more likely associated with NEC and were at greater risk of death.
Social but not metabolic stress in adolescence alters offspring social behavior and oocyte Crhr1/miR-34c expression: a four-generation study
Authors: Gaisler-Salomon Inna , Buchbut Rachel , Dobrovinsky Ilya , Karakra Muntaha , Eyzenberg Revital , Zaidan Hiba 
Published: February 2025

Abstract

Social stress has long-term behavioral and physiological consequences, and studies in male rodents show that it alters sperm miRNA expression and behavior in offspring. The direct and transgenerational impact of social stress in females on brain and germline has not been studied, and its effect on offspring phenotypes remains unknown. In this study, we compared the impact of social and physiological stress on adolescent female rats (F0) and their offspring three generations forward (F1-F3). We found that Social Isolation (SI) and Food and Water Deprivation (FWD) stress during adolescence induced anxiety-like behavior and elevated Nucleus Accumbens Crhr1 mRNA, but SI alone caused depression-like behavior, increased blood corticosterone and altered social recognition in F1 and F2. Notably, Crhr1 and miR-34c expression in oocytes were uniquely affected by SI, as were hypothalamic oxytocin receptor expression and blood oxytocin and BDNF. No stress-induced effects were observed in F3. These findings highlight the impact of the social environment during adolescence and point to germline transcriptional changes that may provide a mechanism for transmission of stress effects in females.
Multi-messenger dynamic imaging of laser-driven shocks in water using a plasma wakefield accelerator
Authors: Balcazar Mario , Thomas Alexander , Tsai Hai-En , Ostermayr Tobias , Chen Qiang , Jacob Robert , Eisentraut Zachary , Esarey Eric , Geddes Cameron , Gonsalves Anthony , Hakimi Sahel , Schroeder Carl , Tilborg Jeroen Van , Vazquez Anthony , Krushelnick Karl , Dyer Gilliss , Trantham Matthew , Campbell Paul , Nees John , Ma Yong , Albert Felicie , Grace Elizabeth , Lemos Nuno , Pagano Isabella , King Paul , Kettle Brendan , Colgan Cary , Los Eva , Mangles Stuart , Simpson Raspberry , Greenwood Benjamin , Kuranz Carolyn 
Published: February 2025

Abstract

Understanding dense fuel hydrodynamics is critical for predicting burning plasma behavior in laser-driven inertial confinement fusion. Traditional diagnostic sources face many limitations in brightness, spatio-temporal resolution, and their ability to capture kinetic effects and electromagnetic fields influencing interaction dynamics. We present a dual-probe, multi-messenger laser wakefield accelerator system, combining ultrafast X-rays and relativistic electron beams at 1~Hz, to interrogate a free-flowing water target in vacuum heated by an intense 200~ps laser pulse. This unique scheme enables high-repetition-rate tracking of the interaction evolution utilizing both particle types. Betatron X-rays revealed a cylindrically symmetric shock compression morphology assisted by low-density vapor, resembling foam-layer-assisted fusion targets. The synchronized electron beam detected time-evolving electromagnetic fields, uncovering charge separation effects and ion species differentiation during plasma expansion – phenomena not captured by photons or standard hydrodynamic simulations. This multi-messenger approach highlights the need for hybrid physics models that integrate the detailed insights from both probes, spanning kinetic to hydrodynamic effects, to accurately predict fusion-relevant plasma dynamics from femtosecond to nanosecond timescales.
Molecular Basis of Prostaglandin E2 Reuptake by Organic Anion Transporter PGT
Authors: Qu Qianhui , Zhu Zhini , Li Yaohui , Xia Hao , Yang Chuanhui , Chao Yulin , Zhou Zixuan , Ba Qian , Li Dianfan 
Published: February 2025

Abstract

Prostaglandins (PGs) are bioactive lipids that regulate inflammation, reproduction, and vasopermeability. Timely clearance of excessive PGs is critical to prevent potential damages caused by prolonged signalling. The high-affinity prostaglandin transporter (PGT) plays an essential role in this termination process by efficiently re-uptaking PGs into cells. Here, we report human PGT structures in different oligomerization and substrate-binding states. Beyond the canonical MFS-fold, PGT harbours a unique cystine-rich extracellular segment that incorporates a Kazal-like domain crucial for PGT localization and activity. Two distinct PGE2-bound structures revealed essential elements for substrate recognition, elucidating a PGE2-flipping process during the multi-stop translocation cycle. Notably, PGT dimerizes in detergent micelles and lipid nanodiscs. This dimerization drastically increases the mobility of the extracellular region and induces a profound rotation of the C-domain transmembrane helices, an unprecedented observation for MFS transporters. These functionally distinct snapshots thus shed light on prostaglandin clearance and reveal uncommon features of MFS transporters.
Diagnosis and Management of Acquired Hemophilia A: A Clinical Analysis from Cho Ray Hospital’s Hematology Department
Authors: Tran Tung T. , Le Phuong-Thao T. 
Published: February 2025

Abstract

Background
Acquired hemophilia A (AHA) is a rare autoimmune disorder caused by autoantibodies to coagulation factor VIII. Patients with AHA often bleed spontaneously, severely, difficult to control, and have high treatment costs.
Aims:We present a case series of AHA patients treated at the Hematology department in Cho Ray Hospital from May 2019 to June 2023.
Methods:
This is a retrospective case series report of patients who were diagnosed with AHA. Demographic information, clinical, laboratory characteristics and treatment were described.
This is a retrospective case series report of patients who were diagnosed with AHA. It describes demographic information, clinical and laboratory characteristics, and treatment.
Results:
29 patients (males, females) were included in the case series. Mean age was 57.1 ± 16.6 years. Median FVIII activity was 2 U/dL (0 – 35). Median inhibitor titer was 30.9 BU (1.5 – 1016.4). Mean hemoglobin levels were 77.5 ± 19.7 g/L. All patients had at least one bleeding episode before being diagnosed with which 21/29 patients were an adverse event. The causes of bleeding were spontaneous (26/29 patients), postoperative (2/29 patients) and after injection (1/29 patient). The common site of bleeding were muscular hematomas (20/29 patients), hematuria (7/29 patients), internal bleeding (3/29 patients) and cerebral hemorrhage (1 patient). The underlying disorders of AHA were idiopathic (22/29 patients), malignancy (4/29 patients) and SLE (3/29 patients). In terms of bleeding treatment, 12 patients received bypass agent including rFVIIa (9 patients) and aPCC (5 patients). The response rate was 91.7%. Thromboembolic events were 0%. All patients received immunosuppressive therapy with corticosteroids alone (19/29 patients), corticosteroids combined with cyclophosphamide (8/29 patients), corticosteroids combined with Rituximab (1/29 patients), and corticosteroids combined with MMF (1 patient). Mean hospitalization period was 12.7 days (5-33 days). 11/29 patients developed secondary infections. 3/29 patients perished in the hospital.
Conclusion:
From our case series, AHA patients often have severe bleeding, high inhibitor titer, and bypassing agents needed. Although the success rate was high, the cost, hospitalization period, and secondary infection are considered disadvantageous factors. More data is required to find the proper treatment which balances benefits and risks.
Constraining climate model projections with observations amplifies future runoff declines
Authors: Kim Hanjun , Lehner Flavio , Dagon Katherine , Lawrence David , Swenson Sean , Wood Andrew W. 
Published: February 2025

Abstract

Climate models are increasingly used to inform water availability projections at regional scales. However, the models' own runoff sensitivities—the change in runoff per unit change of precipitation or temperature—are often biased, which can degrade their projections of runoff change. Specifically, models tend to underestimate the runoff decline in response to warming. Here, we conduct a comprehensive analysis with multiple observational datasets, two climate model generations, and large ensemble sampling of internal climate variability to assess these biases and to constrain future runoff projections across major river basins globally. For basins that can be robustly constrained by available observations, there is a tendency for stronger runoff declines than in the unconstrained case. The constrained projections thus indicate more severe impacts of climate change on water resources than indicated by direct climate model output.
IMPROVE Decision Rule for Carotid Revascularization: Clinician Perspectives on Acceptability and Implementation Barriers
Authors: Bierens Juul , Ament Stephanie , Truijman Martine , de Borst Gert J. , Nederkoorn Paul , Bos Daniel , Joore Manuela , Postma Alida , Kooi Eline , Oostenbrugge Robert van , Smits Luc , Investigators on behalf of the IMPROVE 
Published: February 2025

Abstract

Background: Current selection of patients for carotid revascularization is mainly based on neurological symptoms and the degree of carotid artery stenosis. The IMPROVE decision rule can improve the identification of high-risk patients that may benefit from carotid revascularization. Clinicians dealing with stroke patients must be able to rely on the IMPROVE decision rule during clinical trials to validate the clinical benefits. We assessed the level of acceptance, but also possible barriers for implementation of the IMPROVE decision rule among clinicians in the Netherlands.
Methods: We conducted qualitative semi-structured individual interviews with 40 clinicians involved in stroke care, working in the Department of Neurology (n=18), Vascular Surgery (n=12) or Radiology (n=10) across 10 Dutch academic and non-academic medical centers. After an introduction to the IMPROVE decision rule, clinicians were queried regarding their stance on the proposition “the IMPROVE clinical decision rule meets my approval,”. Next, clinicians were queried about potential barriers expected in implementing this model in clinical practice. All interviews were transcribed and systematically coded to identify barriers to acceptability.
Results: Twenty-nine (72.5%) clinicians agreed, five (12.5%) clinicians (three neurologists, two radiologists) strongly agreed, and another six (15%) clinicians (three neurologists, three vascular surgeons) neither disagreed nor agreed with the proposition. Our analysis identified twelve barriers to acceptability for the IMPROVE decision rule that could be grouped into four categories of origin: lack of evidence, limited clinical practicality, insufficient familiarity, and healthcare burden.
Conclusion: Most clinicians accepted IMPROVE but emphasized the need for clinical evaluation. A feasibility study is required to evaluate the clinical applicability of IMPROVE and its impact on healthcare burden. Additionally, a clinical trial comparing IMPROVE-based revascularization selection with current clinical practice is necessary to demonstrate beneficial patient outcomes.
Aerosol inhibition on photochemical surface ozone formation under future climate and air quality scenarios
Authors: Westervelt Daniel , Gopikrishnan G S , Kuttippurath Jayanarayanan 
Published: February 2025

Abstract

​Aerosols significantly influence tropospheric oxidation and ozone formation by modulating photolysis rates and radical sinks.​ This study employs the GEOS-Chem model to analyze different aerosol heterogeneous uptake coefficients (0, 0.1, 0.2, 0.4) and their effects on photochemical ozone levels across regions in the near-present and under future Shared Socioeconomic Pathways (SSP) scenarios. Higher uptake coefficients enhance the sink of radical species like HO2 and expand the aerosol-inhibited regime (AIR), particularly in otherwise NOx-limited regions like India and East Asia, leading to a notable increase in surface ozone (40–50%), especially during colder months. Projections for 2046 indicate a global reduction in AIR areas, resulting from stricter emission controls. By 2096, the extent of AIR further diminishes, with regions such as Southeast Asia transitioning to NOx-limited conditions, though aerosol uptake of HO2 continues to elevate surface ozone levels by 10–15% in heavily aerosol-loaded areas.