bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘The words of a nation worn down by cares’: classical wisdom and modern crisis in Lin Shu’s Aesop’s Fables
Authors: Porteous Benjamin 
Published: October 2023

Abstract
This article analyses the remarkable translation of Aesop’s Fables produced by the Chinese literatus-turned-cultural-impresario Lin Shu [林紓; 1852–1924] at the turn of the twentieth century. Collaborating with colleagues proficient in English, which he himself was not, Lin translated the Fables into elegant Classical Chinese. This article examines the preface to the translation, which uses Aesop’s status as an enduring classical figure in Western education to argue for the continuing relevance of Classical Chinese in newly constituted school curricula. More importantly though, this article probes at the voluminous epimythia Lin composed for most of the fables in the collection. Written immediately after the humiliating Boxer Protocol, these present a feisty critique of Western imperialism in China. They range in topic from China’s lack of cultural self-confidence to comparative reflection on the status of enslaved Africans in the antebellum USA. Lin was a confident and wilful reader of texts; in his hands, the Fables become a foil for razor-edged polemic. His translation is surely one of the most culturally significant in the Fables’ long and murky textual history, and represents an overlooked monument of classical reception in an East Asia teetering on the violent edge of modernity.
Host-plant phenology mediates facultative ant mutualism in the rare butterfly, Celastrina humulus (Lepidoptera: Lycaenidae)
Authors: Mooney Emily H , Fahland Audrey C , Nolan Hailee A , Swift Abbey M , Schorr Robert 
Published: October 2023

Abstract
Host-plant phenology can directly and indirectly mediate the abundance of insect herbivores. Our objective was to determine how host-plant flowering phenology shapes a facultative ant–lycaenid mutualism. The focus of our research was the hops azure, Celastrina humulus Scott & D. Wright, a rare species whose larvae feed on the pollen-bearing inflorescences of Humulus lupulus var. neomexicanus. We used several approaches to evaluate the role of host-plant flowering phenology in this system. First, we monitored larvae over three study years (2020–2022) to parse the role of host-plant flowering phenology and other factors in shaping the likelihood of ant tending. Second, we tested larval performance at various phenological stages of the host plant. We also quantified variation in soluble proteins and secondary metabolites among inflorescences at varying phenological stages. Lastly, we treated artificial sugar–protein baits with extracts from different phenological stages of the host plant; this allowed us to assess how chemical variation among stages could impact ant recruitment. Monitoring results revealed that the likelihood of ant tending was lowest for larvae on host plants with early-stage inflorescences. These floral stages had the greatest concentrations of both soluble proteins and α-acids (humulone and cohumulone), and in the feeding trial, early-stage flowers enabled greater weight gain for larvae. However, extracts from early-stage flowers reduced ant recruitment to sugar–protein baits. Altogether, these results suggest that early-stage inflorescences enhance larval growth while also reducing the recruitment of mutualist ants. This shows an indirect mechanism whereby changing host-plant phenology can mediate herbivore populations through interactions with ants.
Developing a universal and reliable temporomandibular joint reference system for quantifying morphological and positional changes
Authors: Feng Bin , Wu Qinxin , Wang Jun , Jiang Yun , Liu Zi’ang , Lu Mengting , Liu Zuozhu , Yu Mengfei , Zhu Fudong 
Published: October 2023

Abstract

Objectives
This study aimed to provide a universal and reliable reference system quantifying temporomandibular joint (TMJ) morphological and positional changes.

Methods
Large field-of-view (FOV) cone-beam computed tomography (CBCT) images (20 TMJs) from 10 preorthognathic surgery patients and limited FOV CBCT images (40 TMJs) from 20 splint therapy-treated patients with temporomandibular disorders were collected. TMJ-specific reference system including a TMJ horizontal reference plane (TMJHP) and a local coordinate system (TMJCS) was constructed with landmarks on cranial base. Its application for TMJ measurements and its spatial relationship to common Frankfort horizontal plane (FHP) and maxillofacial coordinate system (MFCS) were evaluated.

Results
Five relevant landmarks were selected to optimally construct TMJ-specific reference system. General parallelism between TMJHP and FHP was demonstrated by minimal angular and constant distance deviation (1.714 ± 0.811º; 2.925 ± 0.817 mm). Additionally, tiny axial orientational deviations (0.181 ± 6.805º) suggested TMJCS rivaled MFCS. Moreover, small deviations in orientations and distances (1.232 ± 0.609º; 0.310 ± 0.202 mm) indicated considerable reliability for TMJCS construction, with intraclass correlation coefficients (ICCs) ranging from 0.999 to 1.000. Lastly, slight discrepancies in translations and rotations revealed high reliability for condylar positional and morphological measurements (ICC, 0.918–0.999).

Limitations
TMJ-specific reference system was merely tested in two representative FOVs.

Conclusions
This study provides a universal and reliable reference system for TMJ assessment that is applicable to both limited and large FOV CBCT. It would improve comparability among diverse studies and enable comprehensive evaluations of TMJ positional and morphological changes during TMJ-related treatment follow-up such as splint therapy and disease progression.
A novel synthesis of light transmission from upcycled polyethylene terephthalate polymer and low-density polyethylene for greenhouse design in tropical climate
Authors: Wongwatcharapaiboon Jitiporn , Chankasem Chanikarn , Lertwattanarak Pusit , Riffat Saffa 
Published: October 2023

Abstract
To support the circular economy in Thai’s agriculture, the main interviewed challenges point to knowledge and knowhow for greenhouse structure and system boosting up productivities. One popular material that possibly affected productivity is transparent polymer film, which can be recycled based on material property and blowing machine condition. This paper investigates the light transmittance performance of transparent polyethylene terephthalate polymer (PET) and low-density polyethylene (LDPE) sheets for use in low-energy greenhouses in tropical climates. The aim of the study is to optimize the thermal performance and light transmittance of these materials to support plant growth and human comfort. The study focuses on seven stages of plant growth, each of which requires different light characteristics including 1) seed, 2) germinating, 3) young seedling, 4) older vine, 5) flowering, 6) fruit bearing and 7) harvesting and drying. Each stage requires different light characteristics, e.g. light intensity, red light, blue light, white light and ultraviolet (UV) and pulsed light (PL). The methodology involves selecting PET and LDPE materials, preparing samples for thermal property and lighting laboratory tests and analysing the results based on suitable criteria. The findings show that LDPE sheets have 28.78% lower light transmittance than PET sheets, making them suitable for supporting the seedling stage and older vines of plant growth. PET sheets, on the other hand, deliver a high intensity of red light, making them suitable for stimulating photosynthesis in older vines and during the harvesting process. The study highlights the importance of considering both thermal performance and light transmittance when selecting materials for low-energy greenhouses in tropical climates.
Observer-based controller design for switched systems with stable and unstable subsystems
Authors: Xie Donglei , Chen Yantao , Qiao Ying 
Published: October 2023

Abstract
This paper studies the problems of both state estimation and observer-based control for a class of switched linear systems with stable and unstable subsystems. By combining slow switching and fast switching mechanism, the observer design and observer-based controller are presented. Firstly, a state observer is developed to estimate the states of switched system by designing admissible edge-dependent switching signal, and a multiple discontinuous Lyapunov function is also constructed to obtain the existence condition of observer. Secondly, based on the stability characteristics of subsystem and the estimated state information, an observer-based feedback controller is proposed. The stability of the closed-loop system is also guaranteed by Lyapunov stability theory. Finally, the feasibility of the proposed method is verified by simulation.
Systematic review on cumulative HIV viraemia among people living with HIV receiving antiretroviral treatment and its association with mortality and morbidity
Authors: Mesic Anita , Decroo Tom , Florence Eric , Ritmeijer Koert , van Olmen Josefien , Lynen Lutgarde 
Published: October 2023

Abstract

Background
We performed a systematic review to generate evidence on the association between cumulative human immunodeficiency virus (HIV) viraemia and health outcomes.

Methods
Quantitative studies reporting on HIV cumulative viraemia (CV) and its association with health outcomes among people living with HIV (PLHIV) on antiretroviral treatment (ART) were included. We searched MEDLINE via PubMed, Embase, Scopus and Web of Science and conference abstracts from 1 January 2008 to 1 August 2022.

Results
The systematic review included 26 studies. The association between CV and mortality depended on the study population, methods used to calculate CV and its level. Higher CV was not consistently associated with greater risk of acquire immunodeficiency syndrome–defining clinical conditions. However, four studies present a strong relationship between CV and cardiovascular disease. The risk was not confirmed in relation of increased hazards of stroke. Studies that assessed the effect of CV on the risk of cancer reported a positive association between CV and malignancy, although the effect may differ for different types of cancer.

Conclusions
CV is associated with adverse health outcomes in PLHIV on ART, especially at higher levels. However, its role in clinical and programmatic monitoring and management of PLHIV on ART is yet to be established.
Innovative UV Protocols Based on Straightforward Mathematical Filtration for Concurrent Estimation of Two Antidiabetic Drugs in Their Brand-New Combination: A Comparative Study
Authors: Nour Israa M , Mohamed Ahmed R , Badrawy Mohamed 
Published: October 2023

Abstract

Background
In 2019, the U.S. Food and Drug Administration approved a brand-new combination of linagliptin and empagliflozin in a formulation called Glyxambi® tablets for managing type 2 diabetes mellitus. Nowadays, spectrophotometric techniques occupy the first place among their peers in terms of ease of application, friendliness to the environment, and low costs.

Objective
This research discusses the development of two very simple spectrophotometric protocols based on zero-order spectra for the determination of linagliptin and empagliflozin.

Methods
The developed protocols were the induced dual-wavelength and absorption correction protocols. Linagliptin could be determined directly at 305 nm, at which the empagliflozin spectrum was zero-crossing. Empagliflozin was determined using the two developed protocols. The induced dual-wavelength technique was developed by calculating the equality factor of linagliptin to cancel its interference. The absorption correction technique was developed by measuring the correction absorption factor.

Results
The concentration ranges of linagliptin and empagliflozin were 1–10 µg/mL and 3–30 µg/mL, respectively. Excellent recovery results were found in bulk, dosage form, and synthetic mixtures. Low LOD and LOQ values were obtained, indicating the high sensitivity of the protocols. The statistical Student’s t-test was performed to compare the results of the applied and reported protocols, indicating no difference between them.

Conclusion
The proposed protocols have the advantages of being straightforward, affordable, and requiring no sophisticated manipulations, just simple mathematical calculations. The proposed protocols are acceptable for routine usage in QC laboratories and in future research applications.

Highlights
Two novel univariate methods were developed for quantitative analysis of linagliptin and empagliflozin in their pharmaceutical and laboratory mixtures, and produced satisfactory results.
Evaluation of identification methods for cryptic Bactrocera dorsalis (Diptera: Tephritidae) specimens: combining morphological and molecular techniques
Authors: Charbonnel Emeline , Chapuis Marie-Pierre , Taddei Andrea , Schutze Mark K , Starkie Melissa L , Benoit Laure , Mouttet Raphaëlle , Ouvrard David 
Published: October 2023

Abstract
The potential for population genomics to elucidate invasion pathways of a species is limited by taxonomic identification issues. The Oriental fruit fly pest, Bactrocera dorsalis (Hendel) belongs to a complex in which several sympatric species are attracted to the same lure used in trapping and are morphologically cryptic and/or reported to hybridize. In this study, we evaluated the taxonomic ambiguity between B. dorsalis and 2 major cryptic species, based on morphological expertise and 289 target specimens sampled across the whole distribution range. Specimens were then subjected to DNA sequence analyses of the COI mitochondrial barcode and the EIF3L nuclear marker to evaluate the potential for molecular identification, in particular for specimens for which morphological identification was inconclusive. To this aim, we produced reference datasets with DNA sequences from target specimens whose morphological identification was unambiguous, which we complemented with 56 new DNA sequences from closest relatives and 76 published and curated DNA sequences of different species in the complex. After the necessary morphological observation, about 3.5% of the target dataset and 47.6% of the specimens from Southeast Asian islands displayed ambiguous character states shared with B. carambolae and/or B. occipitalis. Critical interpretation of DNA sequence data solved morphological ambiguities only when combining both mitochondrial and nuclear markers. COI discriminated B. dorsalis from 5 species; EIF3L and ITS from another species. We recommend this procedure to ensure correct identification of B. dorsalis specimens in population genetics studies and surveillance programs.
HOOKLESS1 acetylates AUTOPHAGY-RELATED PROTEIN18a to promote autophagy during nutrient starvation in Arabidopsis
Authors: Huang Li , Wen Xing , Jin Lian , Han Huihui , Guo Hongwei 
Published: October 2023

Abstract
Acetylation is an important posttranslational modification (PTM) that regulates almost all core processes of autophagy in yeast and mammals. However, the role of protein acetylation in plant autophagy and the underlying regulatory mechanisms remain unclear. Here, we show the essential role of the putative acetyltransferase HOOKLESS1 (HLS1) in acetylation of the autophagy-related protein ATG18a, a key autophagy component that regulates autophagosome formation in Arabidopsis (Arabidopsis thaliana). Loss of HLS1 function suppressed starvation-induced autophagy and increased plant susceptibility to nutrient deprivation. We discovered that HLS1 physically interacts with and directly acetylates ATG18a both in vitro and in vivo. In contrast, mutating putative active sites in HLS1 inhibited ATG18a acetylation and suppressed autophagy upon nutrient deprivation. Accordingly, overexpression of ATG18a mutant variants with lower acetylation levels inhibited the binding activity of ATG18a to PtdIns(3)P and autophagosome formation under starvation conditions. Moreover, HLS1-modulated autophagy was uncoupled from its function in hook development. Taken together, these findings shed light on a key regulator of autophagy and further elucidate the importance of PTMs in modulating autophagy in plants.
Barley MLA3 recognizes the host-specificity effector Pwl2 from Magnaporthe oryzae
Authors: Brabham Helen J , Gómez De La Cruz Diana , Were Vincent , Shimizu Motoki , Saitoh Hiromasa , Hernández-Pinzón Inmaculada , Green Phon , Lorang Jennifer , Fujisaki Koki , Sato Kazuhiro , Molnár István , Šimková Hana , Doležel Jaroslav , Russell James , Taylor Jodie , Smoker Matthew , Gupta Yogesh Kumar , Wolpert Tom , Talbot Nicholas J , Terauchi Ryohei , Moscou Matthew J 
Published: October 2023

Abstract
Plant nucleotide-binding leucine-rich repeat (NLRs) immune receptors directly or indirectly recognize pathogen-secreted effector molecules to initiate plant defense. Recognition of multiple pathogens by a single NLR is rare and usually occurs via monitoring for changes to host proteins; few characterized NLRs have been shown to recognize multiple effectors. The barley (Hordeum vulgare) NLR gene Mildew locus a (Mla) has undergone functional diversification, and the proteins encoded by different Mla alleles recognize host-adapted isolates of barley powdery mildew (Blumeria graminis f. sp. hordei [Bgh]). Here, we show that Mla3 also confers resistance to the rice blast fungus Magnaporthe oryzae in a dosage-dependent manner. Using a forward genetic screen, we discovered that the recognized effector from M. oryzae is Pathogenicity toward Weeping Lovegrass 2 (Pwl2), a host range determinant factor that prevents M. oryzae from infecting weeping lovegrass (Eragrostis curvula). Mla3 has therefore convergently evolved the capacity to recognize effectors from diverse pathogens.
Moving to Smart Specialization for sustainability: the implications on the design of monitoring indicators
Authors: Moujaes Ghinwa 
Published: October 2023

Abstract
Smart Specialization policy, Europe’s place-based innovation policy, is transitioning into an innovation policy for sustainability inspired by academic debate and the urgency of societal challenges. The implications in terms of policy design remain underexplored. This paper studies the policy implications of this transition on the design of monitoring indicators. First, a theoretical framework based on the literature is created. Then, monitoring indicators used in the first policy phase are summarized into categories and themes through inductive and deductive document analysis. The indicators’ strengths and limitations are discussed. By highlighting how monitoring indicators need to adjust to the policy transition, this paper contributes to the literature on innovation policy and Smart Specialization. It also provides guidance to policymakers by developing a framework on indicator design and providing practical recommendations on aspects that need to be considered, captured, and analysed through the indicators.
Delayed melatonin circadian timing, lower melatonin output, and sleep disruptions in myopic, or short-sighted, children
Authors: Chakraborty Ranjay , Seby Chris , Scott Hannah , Tang Victoria , Kemps Eva , Anstice Nicola , Juers Emilia , Lovato Nicole , Taranath Deepa A , Mills Richard A , Lack Leon C 
Published: October 2023

AbstractStudy ObjectivesThis study investigated the differences in melatonin circadian timing and output, sleep characteristics, and cognitive function in myopic and non-myopic (or emmetropic) children, aged 8–15 years.MethodsTwenty-six myopes (refractive error [mean ± standard error mean] −2.06 ± 0.23 diopters) and 19 emmetropes (−0.06 ± 0.04 diopters), aged 11.74 ± 2.31 years were recruited. Circadian timing was assessed using salivary dim-light melatonin onset (DLMO), collected half-hourly for 7 hours, beginning 5 hours before and finishing 2 hours after individual average sleep onset in a sleep laboratory. Nocturnal melatonin output was assessed via aMT6s levels from urine voids collected from 05:30 pm to 8:00 am the following morning. Actigraphy-derived objective sleep timing were acquired for a week prior to the sleep laboratory visit. Cognitive assessments of sustained attention (using psychomotor vigilance task [PVT]) and working memory (using digit spans) were performed on the night of sleep laboratory.ResultsMyopic children (9:07 pm ± 14 minutes) exhibited a DLMO phase-delay of 1 hour 8 minutes compared to emmetropes (7:59 pm ± 13 minutes), p = 0.002. aMT6s melatonin levels were significantly lower among myopes (18.70 ± 2.38) than emmetropes (32.35 ± 6.93, p = 0.001). Myopes also exhibited significantly delayed sleep onset, delayed wake-up time, poor and reduced sleep, and more evening-type diurnal preference than emmetropes (all p &lt; 0.05). Finally, myopes showed a slower reaction time in the PVT (p &lt; 0.05), but not digit span tasks at night.ConclusionsThese findings suggest a potential association between circadian rhythm dysfunction and myopia in children.
Harvest for health in survivors of chronic disease: A demonstration project in the Alabama Black Belt and Mississippi Delta Region
Authors: Bail Jennifer R , Wilson Jeff , Tipre Meghan , Duck Angela , Hall Katherine , Akinyele Oluseun , Bowman Tara , Hardy Claudia , Garner Marcus , Demark-Wahnefried Wendy , Baskin Monica 
Published: October 2023

Abstract
This demonstration project expands upon the Harvest for Health vegetable gardening intervention for cancer survivors by: (i) including survivors of other chronic diseases (i.e. heart disease and diabetes); and (ii) targeting an area with known health inequities (Alabama Black Belt and Mississippi Delta Region). To assess: (i) gardening acceptability (engagement, satisfaction, sustainability, and safety); and (ii) changes over time in health behaviors (fruit and vegetable [F&V] intake, and physical activity) and outcomes (physical performance and anthropometrics). Chronic disease survivors (CDS) were recruited across 15 counties in Alabama and Mississippi and provided with gardening supplies and paired with a master gardener (MG). MGs mentored participants in planning, planting, and maintaining a vegetable garden over a 3-month period. Data collection consisted of an electronic survey (baseline, post-intervention, 6-month follow-up) and community-based physical assessments (baseline and post-intervention). Participants (n = 137; 92% African American; Mage = 65) included individuals with a history of diabetes (56%), heart disease (29%), and cancer (26%). Seventy-five percent of participants engaged in gardening ≥3 times a week. Significant improvements in F&V intake (+0.73, P = .04), physical activity (+49.6, P &lt; .01), and 4 of 7 physical performance measures were observed, while positive trends were seen in others. Eighteen participants withdrew (13% attrition rate). No adverse events occurred. Participants were satisfied with their gardening experience (90%) and were still gardening at 6-month follow-up (85%). Seventy-two percent of participants expanded, or planned on expanding, their garden at 6-month follow-up. Harvest for Health was acceptable and associated with improved health behaviors and outcomes.