bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing hydrological and water quality parameters in the Hathmati Watershed using the SWAT (Soil and Water Assessment Tool)
Authors: Shah Payal Vinitkumar , Shaikh Mohd Zuned M. , Lodha Pradeep P. 
Published: October 2023

Abstract
The study is conducted on the Hathmati River, which is the principal tributary of the Sabarmati River, one of Gujarat's biggest rivers. Indicators of water quality such organic N, organic P, NO3, NH4, NO2, total N, and total P were compared between the observed values in the watershed and the streamflow models. For monthly streamflow and monthly nitrate during the calibration period of 1999–2012, and for 0.87 and 0.56 for the validation period of 2013–2020, respectively, the Nash–Sutcliffe efficiency was 0.89 and 0.79. The measured water quality data at three locations in the watershed were largely compatible with their corresponding modeled values, while the agreement varied by nutrients. Using the parameters used to forecast the hydrological and water quality responses in the watershed region, the Soil and Water Assessment Tool model faithfully duplicated the hydrological and water quality conditions in this agricultural watershed. The results of the modeling indicated that nutrients are one of the key determinants with regard to the quality of the water, in accordance with the current land use and management practices in the watershed. Management practices should be implemented in order to reduce the nutrient load and meet the watershed's requisite water quality standards.
Functional Insight into hTRIR
Authors: Xie Jumin , Mao Hui 
Published: October 2023

:
The uncharacterized C19orf43 was discovered to be associated with hTR
maturation. Our previous work indicated that C19orf43 cleaves distinct RNA types but
not DNA. We then named it hTR-interacting RNase (hTRIR) (Uniprot: Q9BQ61).
hTRIR works in a broad range of temperatures and pH without any divalent cations
needed. hTRIR cleaves RNA at all four nucleotide sites but preferentially at purines. In
addition, hTRIR digested both ends of methylated small RNA, which suggested that it
was a putative ribonuclease. Later, we designed more nucleotides that methylated
small RNA to determine whether it was an exo- and/or endoribonuclease. Unlike
RNase A, hTRIR could digest both ends of methylated RNA oligos 5R5, which
suggested it was potentially an endoribonuclease.
Development of Computational Correlations among Known Drug Scaffolds and their Target-Specific Non-Coding RNA Scaffolds of Alzheimer's Disease
Authors: Roy Debjani , Kundu Shymodip , Mukherjee Swayambhik 
Published: October 2023

Background:
Alzheimer's disease is the most common neurodegenerative disorder. Recent
development in sciences has also identified the pivotal role of microRNAs (miRNAs) in AD
pathogenesis.

Objectives:
We proposed a novel method to identify AD pathway-specific statistically significant
miRNAs from the targets of known AD drugs. Moreover, microRNA scaffolds and corresponding
drug scaffolds of different pathways were also discovered.

Material and Methods:
A Wilcoxon signed-rank test was performed to identify pathway-specific
significant miRNAs. We generated feed-forward loop regulations of microRNA-TF-gene-based
networks, studied the minimum free energy structures of pre-microRNA sequences, and clustered
those microRNAs with their corresponding structural motifs of robust transcription factors. Conservation
analyses of significant microRNAs were done, and the phylogenetic trees were constructed.
We identified 3’UTR binding sites and chromosome locations of these significant microRNAs.

Results:
In this study, hsa-miR-4261, hsa-miR-153-5p, hsa-miR-6766, and hsa-miR-4319 were
identified as key miRNAs for the ACHE pathway and hsa-miR-326, hsa-miR-6133, hsa-miR-4251,
hsa-miR-3148, hsa-miR-10527-5p, hsa-miR-527, and hsa-miR-518a were identified as regulatory
miRNAs for the NMDA pathway. These miRNAs were regulated by several AD-specific TFs,
namely RAD21, FOXA1, and ESR1. It has been observed that anisole and adamantane are important
chemical scaffolds to regulate these significant miRNAs.

Conclusion:
This is the first study that developed a detailed correlation between known AD drug
scaffolds and their AD target-specific miRNA scaffolds. This study identified chromosomal locations
of microRNAs and corresponding structural scaffolds of transcription factors that may be responsible
for miRNA co-regulation for Alzheimer's disease. Our study provides hope for therapeutic
improvements in the existing microRNAs by regulating pathways and targets.
Phytochemicals Showing Antiangiogenic Effect in Pre-clinical Models and
their Potential as an Alternative to Existing Therapeutics
Authors: Senrung Anna , Tripathi Tanya , Aggarwal Nikita , Janjua Divya , Yadav Joni , Chaudhary Apoorva , Chhokar Arun , Joshi Udit , Bharti Alok Chandra 
Published: October 2023

Abstract:
Angiogenesis, the formation of new blood vessels from a pre-existing vascular network, is an important hallmark of several pathological conditions, such as tumor growth and metastasis, proliferative retinopathies, including proliferative diabetic retinopathy and retinopathy of
prematurity, age-related macular degeneration, rheumatoid arthritis, psoriasis, and endometriosis.
Putting a halt to pathology-driven angiogenesis is considered an important therapeutic strategy to
slow down or reduce the severity of pathological disorders. Considering the attrition rate of synthetic antiangiogenic compounds from the lab to reaching the market due to severe side effects,
several compounds of natural origin are being explored for their antiangiogenic properties. Employing pre-clinical models for the evaluation of novel antiangiogenic compounds is a promising
strategy for rapid screening of antiangiogenic compounds. These studies use a spectrum of angiogenic model systems that include HUVEC two-dimensional culture, nude mice, chick chorioallantoic membrane, transgenic zebrafish, and dorsal aorta from rats and chicks, depending upon available resources. The present article emphasizes the antiangiogenic activity of the phytochemicals
shown to exhibit antiangiogenic behavior in these well-defined existing angiogenic models and
highlights key molecular targets. Different models help to get a quick understanding of the efficacy and therapeutics mechanism of emerging lead molecules. The inherent variability in assays and
corresponding different phytochemicals tested in each study prevent their immediate utilization in
clinical studies. This review will discuss phytochemicals discovered using suitable preclinical antiangiogenic models, along with a special mention of leads that have entered clinical evaluation.
Chemical Composition, In vitro and In silico Evaluation of Essential Oil Extracted from Mentha Piperita L. for Lung Cancer
Authors: Singh Bhim , Kumar Amit , Prajapati Kumari Sunita , Patel Shivam , Kumar Shashank , Jaitak Vikas 
Published: October 2023

Background:
Mentha piperita, a naturally occurring herb, is utilized in medicinal formulations. It possesses abundant bioactive elements, including flavonoids and phenolic acid
compounds,that exhibit various properties such as antioxidants, anti-inflammatory and anti-cancer.

Objective:
In the present study, chemical constituents of essential oil extracted from Mentha piperita
were analyzed and identified through GC-MS. In vitro antiproliferative activity was performed on
A549 lung cancer cell line lines. In silico study was conducted by Schrodinger’s Maestro’s software
to identify chemical constituents in the plant as potential EGFR (Epidermal Growth Factor Receptors) inhibitors

Methods:
Hydro-distilled essential oil was analyzed by GC-MS to identify chemical components
based on the retention index and mass fragmentation pattern, which was then tested for its antiproliferative activity by MTT assay against human lung cancer cell lines. All the identified constituents
were investigated in silico for their affinity towards EGFR (Epidermal Growth Factor Receptors).

Results:
A total of thirty constituents were identified where D-carvone (56.69%), L-limonene
(12.36%), squalene (3.36%), cis-carveol (2.93%), and α-amorphene (2.36%) were observed as major
constituents of the essential oil. The essential mentha oil also exhibited antiproliferative activity
against lung cancer cell lines with an IC50 value of 86.05 µg/ml. Furthermore, from the in silico
study, five constituents were identified to have a better affinity for EGFR (Epidermal Growth Factor
Receptors) than that of the standard drug Osimertinib.

Conclusion:
In the present study, the aerial part of the plant Mentha piperita was hydrodistilled.Thirty phytoconstituents were identified through GC-MS data. An in-silico study was performed using
Schrodinger software, and a further in vitro study was performed in which essential oil showedgood
antiproliferative activity against the A549 cancer cell line.
Uncovering the Biological Applications of Cinnamic Acid Derivatives: A Patent Review
Authors: Porto Ricardo Silva , Porto Viviane Amaral 
Published: October 2023

Background:
Cinnamic acid, derived from Cinnamomum cassia, is a natural compound
known for its wide-ranging therapeutic properties and minimal toxicity. Extensive research has
demonstrated the diverse biological activities displayed by cinnamic acid derivatives, encompassing
their potential as agents against cancer, diabetes, microbial infections, tuberculosis, malaria, and
more.

Objective:
This review aims to provide an overview of the latest applications detailing the biological
activity of cinnamic acid derivatives, as documented in patents.

Methods:
The published patent data underwent a prior screening and selection process based on their
relevance and primary focus: the biological activities of cinnamic acid derivatives as potential drugs.
Espacenet, USPTO, and Google Patents were used for this selection.

Results:
Cinnamic acid derivatives demonstrate a range of activities, including anticancer, antibacterial, anti-inflammatory, analgesic, anticholinesterase, and other properties. These biological activities
were investigated across different derivatives, emphasizing their pharmacological potential when
compared to reference compounds.

Conclusions:
Despite several patents have explored the biological properties of cinnamic acid derivatives, there has been a lack of a comprehensive review dedicated to this subject. Accordingly, this
review aims to facilitate the discovery of new and diverse potential drugs with various therapeutic
profiles.
A Review on Novel Nanofiber-based Dermal Applications: Utilization of Polysaccharides
Authors: Rathnasinghe Nimasha , Kaushani K.G. , Jayasinghe R.A. , Nilmini A.H.L.R. , Tissera Nadeeka D. , Wijesena Ruchira N. , Priyadarshana Gayan 
Published: October 2023

Abstract:Nanotechnology is a rapidly expanding field of study because of its numerous dermal applications and benefits in dermal care. It also represents progress in research and development by enhancing product efficacy through the adoption of novel technologies. Nanotechnology is increasingly being used in dermal applications to avoid some of the problems associated with traditional treatments. Dermal applications are the segment of the consumer products market that is expanding the fastest, and their popularity has exploded in recent years. In addition to wrinkles, hyperpigmentation, photoaging, hair damage, and dandruff, nanofibers are now frequently used in dermal treatments for skincare, hair, lips, and nails. These innovative dermal applications using nanofibers provide improved skin penetration, higher stability, site-specific targeting, controlled and prolonged drug release, and high entrapment effectiveness. The outcome of dermal applications can be improved with nanofibers by modifying their structure, functionality, chemical and mechanical resistance, and additional attributes. The importance of biopolymers in processing nanofibers, nanofiber processing methods, an overview of dermal applications' significance, and dermal applications based on nanofibers will all be discussed in this review.
Nature’s Signature in Ayurveda with an Ethnopharmacological Approach:
A Narrative Review
Authors: Balkrishna Acharya , Mishra Shalini , Mishra Rajesh Kumar , Rana Maneesha , Singh Shalini , Arya Vedpriya 
Published: October 2023

:
The nature's signature in Āyurveda i.e. Doctrine of Signatures (DOS), which calls for
utilizing natural substances that resemble a particular body part or organ, is consistent with the
ethnopharmacological practice of choosing therapeutic plants based on their visible physical
qualities. In order to promote health and treat ailments, the ancient Indian medical system known
as Āyurveda employs natural ingredients including plants, minerals, and animal products. The
study of conventional medicine and the application of natural products for therapeutic reasons
are known as ethno-pharmacology. This review explores various research on ayurvedic herbs,
their doctrinal signature, and the status of our understanding of ethno-pharmacology. However, by integrating Āyurveda plants' doctrinal signatures with ethnopharmacological methods,
it might be better to comprehend the therapeutic potential of plants and create novel treatments
for a range of ailments. Combining these two perspectives might assist in understanding how
nature may heal and how natural medicines could improve health and wellness. It was believed
that a plant containing parts that resembled portions of human bodies, animals, or other items
had practical use for those parts, animals, or objects. This philosophy was shown in some of the
Indian medicinal plants that are discussed in this article.
Preparation and Properties of Biocomposite Prepared from Waste
Polystyrene and Prospopis africana Biochar
Authors: Adeniyi Adewale George , Abdulkareem Sulyman A. , Iwuozor Kingsley O. , Emenike Ebuka Chizitere , Adeyanju Comfort A. , Abdulkareem Maryam T. , Omisore Maroof O. 
Published: October 2023

Introduction:
In this study, the pods of Prospopis Africana were thermochemically
converted into biochar and combined with polystyrene resin in varying
proportions to form composites.

Method:
The composites were then characterized to determine their characteristics
using Fourier transform infrared spectroscopy (FTIR), a Scanning electron microscope
coupled with the energy dispersive X-ray Spectrophotometer (SEM-EDX), and a Differential
scanning calorimeter (DSC).

Result:
The FTIR analysis confirmed the changing or shifting of several peaks in the
polystyrene resin and biochar samples. The hardness test showed that incorporating
the Prosopis africana biochar into the solvated polystyrene matrix reduced the latter's
hardness and reduced the impact value. SEM analysis showed that the biochar was
firmly embedded in the polystyrene matrix, showing good adhesion between the matrix
and the filler.

Conclusion:
This study has demonstrated that composites produced from Prosopis
africana biochar filler and polystyrene resin matrix could be used as adsorbents and in
the fabrication of materials requiring good electrical and thermal properties.
Empowering Consumers: The Evolving Paradigm of Customization in
Personal Care Products
Authors: Bhosale Uday , Gaddam Sridevi , Koutam Harish , Sapre Prajkta , Nallan Chaitanya , Syed Shoaeb M 
Published: October 2023

Abstract:
Personal care products available in the market are typically designed for the general
population, assuming they will be suitable for the majority of consumers. However, customization
challenges this notion by focusing on developing products tailored to individual needs, preferences,
and unique factors, such as seasonal variations and geographical demands. It acknowledges
that people may respond diversely to the same product.

:
Customization in personal care products entails the ability to tailor products to an individual's
specific requirements, such as their skin type, hair type, fragrance preferences, etc. Other preferences
include geographical requirements like climate, UV exposure, and cultural preferences,
along with seasonal changes like winter, monsoon, summer, spring, and fall. The entire experience,
including packaging, is personalized.

:
Currently, personal care products represent a relatively small portion, accounting for approximately
10-15% of the overall market, with non-customized products comprising 85-90%. However,
recent data suggests that customization is growing at an annual rate of 15.3%, and it is
projected to surpass non-customized products by 2031.

:
Customization offers several advantages, including a better fit for consumers' physical and mental
health, targeted solutions for specific issues, and increased efficacy. Leading brands in customized
personal care products have span different regions worldwide. For instance, SkinCeuticals,
an American brand, offers customized skincare products tailored to address individual skin concerns
and needs.

:
In India, Vedix and SkinKraft from IncNut Life Style are pioneering brands that provide customized
personal care products based on an individual's skin and hair type, along with a Prakriti
analysis. These brands offer direct-to-consumer services and are headquartered in Hyderabad,
India.

:
The demand for customized personal care products is rapidly increasing worldwide. Beyond individual
needs and preferences, further development is required to cater to seasonal and geographical
requirements, enabling the creation of more effective products.
Clinical and Morphological Parallels in the Etiopathogenesis of Secretory Otitis Media
Authors: Popovych Vasyl , Orishchak Ostap 
Published: October 2023

Introduction. According to global statistics, secretory otitis media (SOM) ranks first among middle ear infections. This pathology is believed to be characteristic of the pediatric population; however, recent global statistics indicate an increase in the percentage of SOM cases among the adult population. Information about adult-onset SOM varies, with no consensus on the causes of its occurrence. Diverse clinical presentation of the condition, often unsatisfactory treatment outcomes, and a high percentage of recurrences have necessitated a more in-depth study of the etiological factors associated with adult-onset SOM.
The objective of the research was to determine clinical and morphological parallels in the etiopathogenesis of adult-onset SOM as well as to establish the relationship between the clinical, otoscopic, and endoscopic presentations and pathomorphological changes in the tubal tonsils in these patients.
Materials and Methods. Sixty-eight (38 men and 30 women) patients with SOM at the age of 18 to 65 years were examined. Fifty-three patients were diagnosed with unilateral pathological process, while in 15 individuals, bilateral SOM was observed. All the patients underwent a comprehensive assessment of their complaints, collection of their medical history, and a full ear, nose, and throat examination using conventional methods, optical techniques, video endoscopy of the nasopharynx and tubal tonsils, and otomicroscopy. In 15 patients, to exclude a malignant process, tissue samples from the tubal tonsils were taken for pathological examination.
Results. One of the causes of adult-onset SOM could be pathomorphological changes in the tubal tonsils, specifically their inflammation, hypertrophy, and in some cases, tumours. The clinical course and stages of SOM development depend on the duration of auditory tube obstruction. Inflammation of the tubal tonsils usually results in catarrhal and serous SOM, while hypertrophy or hyperplasia of the tubal tonsils is observed in patients with mucous SOM.
Conclusions. Pathomorphological changes in the tubal tonsils have been established as one of the reasons for developing SOM in adults. Both the clinical presentation of SOM and the stage of its progression depends on the type of pathomorphological changes, their localization (upper or lower pole), and the duration of auditory tube obstruction. A prolonged, recurrent, and treatment-resistant course of SOM may be associated with hypertrophy of the tubal tonsil or tumours. Clinical and morphological parallels identified by us will enable timely utilization of effective etiopathogenetic treatment of SOM and prevent the occurrence of complications.
Influence of Medicinal Plants Extracts from the Flora of Ukraine on the Growth of Cultures of Candida Yeast Fungi Selected from Dental Patients
Authors: Ohiienko Tetiana 
Published: October 2023

Antimycotics, which are widely used in this case, increasingly do not give the desired effect, since various types of Candida fungi are constantly modified forming resistant strains. This necessitates the search for new antifungal medication to affect them. From this point of view, medicinal plants are interesting for the research. They contain a number of biologically active compounds including substances that have antifungal properties against yeast-like fungi.
The aim. The objective of our research was to study in an experiment the influence of medicinal plants extracts of the flora of Ukraine on the growth of cultures of Candida various species associated with dental pathology.
Materials and methods. We selected 15 aqueous-ethanol extracts for further research which showed significant antifungal activity against C. albicans, C. tropicalis, C.lusitaniae, C.kefyr і C. lipolytica.on the basis of the initial screening of the antifungal properties of various medicinal plants of the flora of Ukraine.
Results. According to the results of the work performed, 15 extracts were selected for further study by a more accurate method of serial dilutions in order to establish their fungicidal/fungistatic concentrations. The results of the testing showed that all 16 studied extracts in the dilution range from 1:20 to 1:640 showed at least a fungistatic effect against most strains of Candida fungi associated with dental pathological processes.
Conclusions. The obtained research results indicate a significant prospect of using plant extracts and medication based on them for oral thrush treatment.
Effectiveness of miniscrew-supported maxillary molar distalization according to temporary anchorage device features and appliance design: systematic review and meta-analysis
Authors: Ceratti Chiara , Serafin Marco , Del Fabbro Massimo , Caprioglio Alberto 
Published: October 2023

ABSTRACT

Objectives
To evaluate the effectiveness of distalizing maxillary first molars (U6) by temporary anchorage devices (TADs) according to their location (palatal, buccal, and zygomatic), their number, and appliance design.

Materials and Methods
An electronic search of maxillary molar distalization with TADs was done through April 2023. After study selection, data extraction, and risk-of-bias assessment, meta-analyses were performed for the extent of distalization, distal tipping, and vertical movement of U6 using the generic inverse variance and random-effects model. The significance level was set at 0.05.

Results
Forty studies met the inclusion criteria: 4 randomized controlled trials (RCTs), 13 prospective studies, and 23 retrospective studies (total of 1182 patients). Distalization of the U6 was not significantly greater (P = .64) by palatal (3.74 mm) and zygomatic (3.68 mm) than by buccal (3.23 mm) TADs. Distal tipping was significantly higher (P &lt; .001) in nonrigid (9.84°) than in rigid (1.97°) appliances. Vertical movement was mostly intrusive and higher but not significantly different (P = .28) in zygomatic anchorage (−1.16 mm).

Conclusions
Distalization of U6 with TADs can be an effective and stable treatment procedure, especially when performed with rigid palatal appliances. However, further RCTs or prospective cohort studies are strongly recommended to provide more clinical evidence.