bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between myocardial work indices and cardiovascular events according to hypertension in the general population
Authors: Olsen Flemming Javier , Skaarup Kristoffer Grundtvig , Lassen Mats Christian Højbjerg , Johansen Niklas Dyrby , Jensen Gorm Boje , Schnohr Peter , Marott Jacob Louis , Søgaard Peter , Gislason Gunnar , Svendsen Jesper Hastrup , Møgelvang Rasmus , Aalen John Moene , Smiseth Otto Armin , Remme Espen Wattenberg , Biering-Sørensen Tor 
Published: November 2023

Abstract

Aims
Pressure-strain loop (PSL) analysis is a novel echocardiographic tool capable of assessing myocardial work non-invasively. In this study, we aim to evaluate the prognostic value of myocardial work indices in the general population.

Methods and results
This was a prospective community-based cohort study (n = 4466). PSL analyses were performed to acquire global work index (GWI), global constructive work (GCW), global wasted work, and global work efficiency (GWE). The endpoint was a composite of heart failure or cardiovascular death (HF/CVD). Survival analysis was applied. A total of 3932 participants were included in this analysis (median age: 58 years, 43% men). Of these, 124 (3%) experienced the outcome during a median follow-up period of 3.5 years [interquartile range (IQR): 2.6–4.4 years]. Hypertension significantly modified the association between all work indices and outcome (P for interaction &lt; 0.05), such that work indices posed a higher risk of outcome in non-hypertensive than in hypertensive participants. After adjusting for Atherosclerosis Risk in Communities (ARIC)-HF risk variables, all work indices predicted outcome in non-hypertensive participants, but only GWI, GCW, and GWE predicted outcome in hypertensive participants [GWI: hazard ratio (HR) = 1.12 (1.07–1.16), per 100 mmHg% decrease; GCW: HR = 1.12 (1.08–1.17), per 100 mmHg% decrease; GWE: HR = 1.08 (1.04–1.12), per 1% decrease]. Only GWE significantly increased C-statistics when added to ARIC-HF risk variables in hypertensive participants (C-stat 0.865 vs. 0.877, P for increment = 0.003).

Conclusion
Hypertension modifies the association between myocardial work indices and HF/CVD in the general population. All work indices are associated with outcome in normotensive participants. GWI, GCW, and GWE are independently associated with outcome in hypertension, but only GWE improves risk prediction.
Distal His bundle pacing in a patient with surgically corrected complex Ebstein anomaly and symptomatic second-degree atrioventricular block: a case report
Authors: Koev Ivelin , Ng G Andre , Bolger Aidan P , Ibrahim Mokhtar 
Published: November 2023

Abstract

Background
Ebstein’s anomaly occurs when there is an apical displacement of the tricuspid valve with septal and posterior valve leaflets tethering. This condition often occurs in association with other congenital, structural, or conduction system diseases, including intracardiac shunts, valvular lesions, arrhythmias, accessory conduction pathways, and first-degree atrioventricular (AV) block. We present for the first time a case of a patient with Ebstein’s anomaly who presented with second-degree Mobitz II AV block and was successfully treated with conduction system pacing (CSP) due to her young age and the likelihood of a long-term high percentage of pacing.

Case summary
We present a case of a 42-year-old lady with a background of complex congenital heart disease, including severe pulmonary stenosis, Ebstein anomaly, and atrial septal defect (ASD). She required complex surgical intervention, including tricuspid valve (TV) repair and subsequently replacement, ASD closure, and pulmonary balloon valvuloplasty. She presented to our hospital with symptomatic second-degree Mobitz II AV block (dizziness, shortness of breath, and exercise intolerance) and right bundle branch block (RBBB) on her baseline ECG. Her echocardiogram showed dilated right ventricle (RV) and left ventricle (LV) with low normal LV systolic function. Due to her young age and the likelihood of a long-term high percentage of RV pacing, we opted for CSP after a detailed discussion and patient consent. The distal HIS position is the preferred pacing strategy at our centre. We could not cross the TV with the standard Medtronic C315 HIS catheter, so we had to use the deflectable C304 HIS catheter. Mapping and pacing of the distal HIS bundle were achieved by Medtronic Selectsecure 3830, 69 cm lead. HIS bundle pacing led to the correction of both second-degree Mobitz II AV block and pre-existing RBBB. The implantation was uneventful, and the patient was discharged home the next day without any acute complications.

Discussion
Distal HIS pacing is feasible in patients with surgically treated complex Ebstein anomaly and heart block. This approach can normalize the QRS complex with a high probability of preserving or improving LV function.
Diagnostic accuracy, clinical characteristics, and prognostic differences of patients with acute myocarditis according to inclusion criteria
Authors: Roy Roman , Cannata Antonio , Al-Agil Mohammad , Ferone Emma , Jordan Antonio , To-Dang Brian , Sadler Matthew , Shamsi Aamir , Albarjas Mohammad , Piper Susan , Giacca Mauro , Shah Ajay M , McDonagh Theresa , Bromage Daniel I , Scott Paul A 
Published: November 2023

Abstract

Introduction
The diagnosis of acute myocarditis (AM) is complex due to its heterogeneity and typically is defined by either Electronic Healthcare Records (EHRs) or advanced imaging and endomyocardial biopsy, but there is no consensus. We aimed to investigate the diagnostic accuracy of these approaches for AM.

Methods
Data on ICD 10th Revision(ICD-10) codes corresponding to AM were collected from two hospitals and compared to cardiac magnetic resonance (CMR)-confirmed or clinically suspected (CS)-AM cases with respect to diagnostic accuracy, clinical characteristics, and all-cause mortality. Next, we performed a review of published AM studies according to inclusion criteria.

Results
We identified 291 unique admissions with ICD-10 codes corresponding to AM in the first three diagnostic positions. The positive predictive value of ICD-10 codes for CMR-confirmed or CS-AM was 36%, and patients with CMR-confirmed or CS-AM had a lower all-cause mortality than those with a refuted diagnosis (P = 0.019). Using an unstructured approach, patients with CMR-confirmed and CS-AM had similar demographics, comorbidity profiles and survival over a median follow-up of 52 months (P = 0.72). Our review of the literature confirmed our findings. Outcomes for patients included in studies using CMR-confirmed criteria were favourable compared to studies with endomyocardial biopsy-confirmed AM cases.

Conclusion
ICD-10 codes have poor accuracy in identification of AM cases and should be used with caution in clinical research. There are important differences in management and outcomes of patients according to the selection criteria used to diagnose AM. Potential selection biases must be considered when interpreting AM cohorts and requires standardization of inclusion criteria for AM studies.
Characterization of unipolar electrogram morphology: a novel tool for quantifying conduction inhomogeneity
Authors: Ye Ziliang , van Schie Mathijs S , Pool Lisa , Heida Annejet , Knops Paul , Taverne Yannick J H J , Brundel Bianca J J M , de Groot Natasja M S 
Published: November 2023

Abstract

Aims
Areas of conduction inhomogeneity (CI) during sinus rhythm may facilitate the initiation and perpetuation of atrial fibrillation (AF). Currently, no tool is available to quantify the severity of CI. Our aim is to develop and validate a novel tool using unipolar electrograms (EGMs) only to quantify the severity of CI in the atria.

Methods and results
Epicardial mapping of the right atrium (RA) and left atrium, including Bachmann’s bundle, was performed in 235 patients undergoing coronary artery bypass grafting surgery. Conduction inhomogeneity was defined as the amount of conduction block. Electrograms were classified as single, short, long double (LDP), and fractionated potentials (FPs), and the fractionation duration of non-single potentials was measured. The proportion of low-voltage areas (LVAs, &lt;1 mV) was calculated. Increased CI was associated with decreased potential voltages and increased LVAs, LDPs, and FPs. The Electrical Fingerprint Score consisting of RA EGM features, including LVAs and LDPs, was most accurate in predicting CI severity. The RA Electrical Fingerprint Score demonstrated the highest correlation with the amount of CI in both atria (r = 0.70, P &lt; 0.001).

Conclusion
The Electrical Fingerprint Score is a novel tool to quantify the severity of CI using only unipolar EGM characteristics recorded. This tool can be used to stage the degree of conduction abnormalities without constructing spatial activation patterns, potentially enabling early identification of patients at high risk of post-operative AF or selection of the appropriate ablation approach in addition to pulmonary vein isolation at the electrophysiology laboratory.
Undermining support for COVID-19 public health policies: an analysis of the impact of subversive conspiracy narratives on Czech General Practitioners
Authors: Volek Jaromír , Moravec Václav 
Published: November 2023

Abstract

Background
Limited knowledge exists regarding the impact of COVID-19 conspiracy theories on the professional practice of general practitioners (GPs). This study aimed to identify the basic characteristics of GPs who endorse COVID-19 conspiracy beliefs and compare their level of support for COVID-19 health policies with GPs who do not believe in conspiracies.

Methods
Between January and February 2021, a representative online survey was conducted among 1163 GPs in the Czech Republic. The sample was designed to be representative of members of The Association of GPs of the Czech Republic.

Results
The survey revealed that nearly 14% of the GPs surveyed believed in one or more COVID-19 conspiracies. The average age of GPs who endorsed conspiracies was 58, which was higher than the rest of the sample (average age of 50). GPs who believed in conspiracies were less likely to support COVID-19 public health policies and therapy recommendations, including vaccination. Logistic and linear regression analyses indicated that doctors who believed in conspiracies were 2.62 times less likely to have received a COVID-19 vaccine. Mediation analysis showed that approximately one-quarter (23.21%) of the total effect of trust in government information on support for public health policies was indirectly mediated by the endorsement of COVID-19 conspiracy beliefs.

Conclusions
The study findings suggest a concerning association between belief in COVID-19 conspiracies and a reduced level of support for public health policies among GPs. These results underscore the importance of incorporating the ‘conspiracy agenda’ into medical authorities’ more effective public health communication strategies.
The eco-evolutionary origins of life
Authors: Kalambokidis Maria , Travisano Michael 
Published: November 2023

Abstract
The origin of life remains one of the greatest enigmas in science. The immense leap in complexity between prebiotic soup and cellular life challenges historically “chemistry-forward” and “biology-backwards” approaches. Evolution must have bridged this gap in complexity, so understanding factors that influence evolutionary outcomes is critical for exploring life’s emergence. Here, we review insights from ecology and evolution and their application throughout abiogenesis. In particular, we discuss how ecological and evolutionary constraints shape the evolution of biological innovation. We propose an “eco-evolutionary” approach, which is agnostic towards particular chemistries or environments and instead explores the several ways that an evolvable system may emerge and gain complexity.
Amor Mundi: The Ecology and Praise of Transience in Rilke’s Duino Elegies
Authors: Sorenson Alexander 
Published: November 2023

Abstract
Among the many puzzles in Rainer Maria Rilke's Duino Elegies is the ninth elegy’s declaration that the things of the world are disappearing, but that the only way to rescue them from this fate is to make them ‘invisible’. To make sense of this paradoxical scenario, the present article first examines in the light of several theoretical frameworks (for example, Walter Benjamin’s aura, Jean-Luc Maron’s apophasis and Hannah Arendt’s natality) how Rilke portrays the relationship between praise and mourning, proposing as an interpretive key hymnic language’s depicted capacity to illuminate transience. The article then demonstrates how this dimension of Rilke’s text articulates a vision of an authentically ecological relation to phenomena, one that involves an ecstatic exchange between subject and environment and that ultimately upends paradigmatic hierarchies of ‘human/non-human’ by introducing a modality of love grounded in loss rather than in possession.
Forest-Based Employment in the Southern United States amidst the COVID-19 Pandemic: A Causal Inference Analysis
Authors: Chizmar Stephanie , Parajuli Rajan , Bruck Sonia , Frey Gregory , Sills Erin 
Published: November 2023

Abstract
In response to the COVID-19 pandemic, some governments instituted mandatory stay-at-home policies. As these policies made exceptions for essential industries such as the forest sector, it is not clear a priori whether and how these policies would affect forest-based employment. This study examined the effect of mandatory stay-at-home orders on employment in the forest sector in forest dependent counties in eleven southern states in the United States. We estimated panel event study models in addition to difference-in-difference models to evaluate the policy effects with respect to initial treatment as well as average effects to the treated counties during treatment. We found that employment in wood product manufacturing was lower on average in counties under a lockdown order compared with employment in counties without an active order. We also found that employment in the aggregate forest sector in counties that implemented the policy was significantly lower than employment in counties without the policy up to 9 months following initial enactment compared with the underlying difference between treated and control counties one month prior to treatment. Overall, our findings suggest that lockdown policies had a limited effect on employment in essential industries such as wood-based manufacturing sectors in the southern states.
Study Implications: This study uses causal inference techniques to assess the effect of lockdown orders on forest-based employment in 11 southern states. Results suggest effects of lockdown orders were limited to the aggregate forest sector and wood product manufacturing, likely due to the rapid designation of the sector as essential and the reduced production of sawmills. The other industries within the sector were not significantly affected, implying that industries designated as essential may be more resilient to short-term shocks. These findings can be used to inform discussions on potential policy responses to future disasters, including how different interventions interact with one another.
Life Course Perspectives of Aging With Schizophrenia Spectrum Disorders in Psychiatric and Long-Term Care Facilities
Authors: Walker Verónica García , Harrison Tracie C 
Published: November 2023

Abstract

Background and Objectives
Individuals with schizophrenia spectrum disorders must manage residual symptoms as they age, and they may experience premature or accelerated aging in comparison with those without their diagnosis. To explore their life course perspectives, we interviewed institutionalized adults aging with schizophrenia spectrum disorders in middle and older age.

Research Design and Methods
We used an exploratory descriptive design and qualitative methods. Participants answered semistructured, open-ended questions about perceptions of their mental illness along the life course.

Results
Participants (N = 30, age 45–83 years) were from an acute care psychiatric facility and a long-term care facility: 16 (53%) men, 14 (47%) women; 6 (20%) Hispanic, 10 (33%) African American, 14 (47%) non-Hispanic White. Participants’ life course included traumas from violence, homelessness, and stigma; psychiatric symptoms such as worry and sadness; and age-related physiological symptoms including illness, loss of strength, falls, and incontinence, with falls and incontinence reported only in long-term care. Aging within institutionalization included lack of privacy and autonomy, and isolation (less socialization). Participants provided insights for potential improvements.

Discussion and Implications
Because these aging adults are experts on their own care, researchers should continue to seek their input to inform their healthcare.
Evaluating the impacts of environmental and fishery variability on the distribution of bigeye tuna in the Pacific Ocean
Authors: Lin H , Wang J , Zhu J , Chen X 
Published: November 2023

Abstract
Climate change-induced variabilities in the environment and fishing pressure affect the distribution and abundance of bigeye tuna in the Pacific Ocean. Understanding the causal relationships among these factors is complicated and challenging. We constructed a multi-output neural network model based on data from four types of bigeye tuna fisheries (longline and purse seine in the west-central and eastern Pacific Ocean, respectively) and marine environmental data, aiming to analyse the response of bigeye tuna to natural and anthropogenic factors from 1995 to 2019 in the Pacific Ocean. The input layer weights were used to explore the importance of environmental variable, while the output layer weights evaluated the contribution of fishing operations. These factors determined the final spatiotemporal distribution and abundance dynamics for bigeye tuna. The optimal model predicted a strong correlation between the locations of major habitats and El Niño southern Oscillation (ENSO) events, indicating that bigeye tuna abundance dynamics respond to the intensity of climate variability. During El Niño events, suitable conditions lead to an expansion of the main habitats east of 170°W, while during La Niña events, the strengthening of the westward advection leads to the contraction of major habitats west of 170°W. Furthermore, the resource abundance of bigeye tuna is predicted to be higher during moderate to weak El Niño events than during strong El Niño events. The abundances in purse seine and longline-dependent fisheries demonstrate significant different distribution patterns under different ENSO events, reflecting the unique environmental preferences at different life stages of bigeye tuna. Given the increasing frequency of climate variability and escalating fishing pressures, our findings provide beneficial insights for the sustainable development of bigeye tuna resource in the Pacific Ocean.
Development of novel waxy bone haemostatic agents composed of biodegradable polymers with osteogenic-enhancing peptides in rabbit models
Authors: Ohno Tsukasa , Suenaga Hiroto , Yamawaki-Ogata Aika , Kanie Kei , Kato Ryuji , Uto Koichiro , Ebara Mitsuhiro , Ito Hideki , Narita Yuji , Usui Akihiko , Mutsuga Masato 
Published: November 2023

Abstract

OBJECTIVES
The use of bone wax (BW) is controversial for sternal haemostasis because it increases the risk of wound infection and inhibits bone healing. We developed new waxy bone haemostatic agents made from biodegradable polymers containing peptides and evaluated them using rabbit models.

METHODS
We designed 2 types of waxy bone haemostatic agents: peptide wax (PW) and non-peptide wax (NPW), which used poly(ε-caprolactone)-based biodegradable polymers with or without an osteogenesis-enhancing peptide, respectively. Rabbits were randomly divided into 4 groups based on treatment with BW, NPW, PW or no treatment. In a tibial defect model, the bleeding amount was measured and bone healing was evaluated by micro-computed tomography over 16 weeks. Bone healing in a median sternotomy model was assessed for 2 weeks using X-ray, micro-computed tomography, histological examination and flexural strength testing.

RESULTS
The textures of PW and NPW (n = 12 each) were similar to that of BW and achieved a comparable degree of haemostasis. The crevice area of the sternal fracture line in the BW group was significantly larger than that in other groups (n = 10 each). The PW group demonstrated the strongest sternal flexural strength (n = 10), with complete tibial healing at 16 weeks. No groups exhibited wound infection, including osteomyelitis.

CONCLUSIONS
Waxy biodegradable haemostatic agents showed satisfactory results in haemostasis and bone healing in rabbit models and may be an effective alternative to BW.
MALDI–TOF bacterial subtyping for rapid detection of biomarkers in Staphylococcus aureus from subclinical bovine mastitis
Authors: Lopes Thainara , Fidelis Carlos E , Silva Amanda T F , Mota Rinaldo A , Rall Vera L M , dos Santos Marcos V , Gonçalves Juliano L 
Published: November 2023

Abstract

Aims
This study aimed to evaluate matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) bacterial subtyping for the rapid detection of biomarkers in Staphylococcus aureus from subclinical bovine mastitis.

Methods and results
A total of 229 S. aureus isolates were obtained from milk samples collected from cows with subclinical mastitis using microbiological culture. Staphylococcus aureus isolates were also submitted to PCR analysis targeting the mecA and mecC genes, which are indicative of methicillin resistance. Confirmation of the species was achieved through MALDI–TOF MS analysis. To analyze antimicrobial resistance patterns, the MALDI BioTyper Compass Explorer and ClinProTools Bruker software were employed, and dendrograms were generated using Bionumerics software.

Conclusions
MALDI–TOF MS successfully identified S. aureus at the species level, but no methicillin resistance was observed. Moreover, spectral typing displayed limited similarity when compared to pulsed-field gel electrophoresis (PFGE).