bluuebunny/crossref_metadata_2025_split huggingface dataset:
For every action a reaction? The polarizing effects of women's rights and refugee immigration: A survey experiment in 27 EU member states
Authors: ALEXANDER AMY , CHARRON NICHOLAS , OFF GEFJON 
Published: February 2024

AbstractBuilding on research on cultural threat‐induced polarization, we investigate the effect of the individual‐level salience of cultural threats on polarization between social liberals and conservatives. In a unique survey experiment conducted with 129,000 respondents nested in 208 regions in 27 European Union (EU) member states, we manipulate the presence of two cultural threats, women's rights, and refugee immigration, to test their polarizing effects on social liberals’ and social conservatives’ support for traditional values. We find that priming the threat of refugee immigration polarizes conservatives and liberals equally. Yet, introducing the salience of women's rights leads to lower preferences for traditional values, particularly among more liberal respondents. Our findings demonstrate: 1) the study of backlash should distinguish individuals by their predisposition to backlash, rather than studying the population as a whole; and 2) social conservatives’ backlash should be studied conjointly with social liberals’ counter‐reactions to backlash. Future research may investigate why different cultural threats provoke different reactions.
End‐of‐life decision‐making in the emergency department and intensive care unit: Health professionals' perspectives on and knowledge of the law in Queensland
Authors: Hewitt Jayne , Alsaba Nemat , May Katya , Kang Evelyn , Cartwright Colleen , Willmott Lindy , White Ben , Marshall Andrea P 
Published: February 2024

AbstractObjectiveTo investigate ED and intensive care unit healthcare professionals' perspectives and knowledge of the law that underpins end‐of‐life decision‐making in Queensland, Australia.MethodsAn online survey with questions about perspectives, perceived, and actual, knowledge of the law was distributed by the professional organisations of medical practitioners, nurses and social workers who work in Queensland EDs and intensive care units.ResultsThe survey responses of 126 healthcare professionals were included in the final analysis. Most respondents agreed that the law was relevant to end‐of‐life decision‐making, but that clinician and family consensus mattered more than following the law. Generally, doctors' legal knowledge was higher than nurses'; however, there were significant gaps in the knowledge of all respondents about the operation of advance health directives in Queensland.ConclusionsThe legal framework that supports end‐of‐life decision‐making for adults who lack decision‐making capacity has been in place for more than two decades. Despite frequently being involved in making or enacting these decisions, gaps in the legal knowledge of healthcare professionals who work in EDs and intensive care units in Queensland are evident. Further research to better understand how to improve knowledge and application of the law is warranted.
Revisiting the concept of the public interest in accounting: A stakeholder analysis
Authors: Dellaportas Steven , Ji Sophia , Siriwardhane Pavithra , Luo Dudu 
Published: February 2024

AbstractThis study contributes to the discussion on the meaning and operation of the public interest. The all‐inclusive perspective in defining the public interest adopted by IFAC, was criticised by stakeholders, predominantly professional bodies, for being broad and impractical. IFAC responded by proposing a process‐oriented approach to simplify the definition and assessment of public interest policies and actions. The limitations in understanding the public interest from both conceptual and practical perspectives have not been addressed in a significant way, suggesting there is room for further guidance on the meaning of the public interest and how to implement it.
Tumor des follikulären Infundibulums – Neubewertung in einer Serie von 28 Patienten mit kritischer Analyse der Literatur
Authors: Wilk Michael , Zelger Bettina G. , Zelger Bernhard 
Published: February 2024

ZusammenfassungHintergrund und ZieleDer Tumor des follikulären Infundibulums (TFI) wurde als Neoplasie – isoliert und multipel – und in Assoziation mit anderen epithelialen Läsionen beschrieben. Seine endgültige histopathologische Definition wird kontrovers diskutiert.Patienten und MethodikWir präsentieren eine retrospektive Serie von 28 Patienten mit TFI beziehungsweise TFI‐ähnlichen Veränderungen. Ergänzend wurde die in MEDLINE aufgeführte Literatur zum Thema TFI recherchiert und die darin publizierten Abbildungen interaktiv diskutiert und analysiert.ErgebnisseUnsere Patienten waren 16 Frauen und 12 Männer. TFI‐ähnliche Veränderungen fanden sich bei fünf Patienten mit Nävus sebaceus, zwei Trichofollikulomen, einer erweiterten Pore Winer, acht Virusakanthomen, einem Dermatofibrom, sechs seborrhoischen Keratosen, drei aktinischen Keratosen, einem invasiven Plattenepithelkarzinom und einem Basalzellkarzinom in Kombination mit Plattenepithelkarzinom/aktinischer Keratose. Nach Sichtung der Literatur, insbesondere von solitären Fällen von TFI, betrachten wir diese größtenteils als Variante von seborrhoischen Keratosen mit variablem Ausmaß von infundibulärer, isthmischer und/oder sebazärer Differenzierung mit oder ohne Regression.SchlussfolgerungenWir werten TFI insgesamt als ein epitheliales Wachstumsmuster, das bei hamartomatösen, entzündlichen inkludierend infektiösen, reaktiven oder neoplastischen Prozessen auftreten und in den meisten solitären Formen am ehesten innerhalb des histologischen Spektrums seborrhoischer Keratosen eingeordnet werden kann.
Regional vs. Local Isotopic Gradient: Insights and Modeling from Mid‐Mountain Areas in Central Italy
Authors: Tazioli Alberto , Fronzi Davide , Palpacelli Stefano 
Published: February 2024

AbstractMountainous zones are often characterized by complex orography and contacts between different aquifers that usually complicate the use of isotope hydrology techniques. The Apennine chain (Italy) and 10 mountain and mid‐mountain areas belonging to it are the objective of this study. An original isotopic data treatment, able to identify the most probable recharge area for several springs/springs' groups/wells, has been developed. The method consists of a two‐step approach: (1) the determination of the spring/wells computed isotope recharge elevation; (2) an advanced δ18O precipitation distribution model over the study area supported by statistical and GIS‐based procedures implemented by two processes: first, the clipping of precipitation δ18O values (depicted from the δ18O–elevation relationships obtained for each study area) over a most probable recharge area for each analyzed spring or well and, second, the calculation of the overlapping distribution between the spring/well mean δ18O values ± σ and the precipitation δ18O content for each outcropping aquifer. A new regional δ18O gradient covering 150 km latitudinal length of central Italy has been defined. Seven LMWL and δ18O–elevation relationships able to represent the local precipitation isotopic composition have been obtained. The mean elevation of the springs and wells recharge areas have been assessed by a comparison between the obtained gradient with nine δ18O gradients available in the literature and those obtained at a local scale. The new isotopic modeling approach can stress whether the mere isotope modeling based on the stable isotope of oxygen agrees with the hydrogeological setting of the study areas.
La sécurité et la santé au travail en tant que droits fondamentaux: étude historique comparative de la stratégie du réalisme vigilant de l'OIT
Authors: HILGERT Jeffrey 
Published: February 2024

RésuméL'auteur présente une étude historique comparative de l'action de l'OIT en matière de sécurité et de santé au travail (SST) analysées comme des droits fondamentaux. Durant les vingt années qui ont suivi l'adoption du Pacte international relatif aux droits économiques, sociaux et culturels, l'Organisation a opté pour une approche réaliste et défendu l'idée que la protection de la SST supposait que les conditions économiques nécessaires soient réunies. L'article revisite cette histoire à la lumière de deux éléments: l'émergence d'une nouvelle réalité, faite d'incertitude, et l'ajout de la SST au cadre des principes et droits fondamentaux au travail de l'OIT. Il montre que l'approche du réalisme vigilant pourrait être appliquée aux activités actuelles de l'OIT dans le champ de la SST.
CD14−CD10−CD45+HLA‐DR−SSC+ neutrophils may be granulocytic myeloid‐derived suppressor cell–like cells and relate to disease progression in non‐Hodgkin's lymphoma patients
Authors: Zhou Ji , Xiao Hao , Wang Zhitao , Wang Huiping , Liang Xue , Zhai Zhimin , Hong Jingfang 
Published: February 2024

AbstractWe explored the frequency of CD14−CD10−CD45+HLA‐DR−SSC++ neutrophils (CD10− neutrophils) in patients with non‐Hodgkin's lymphoma (NHL), and their immunologic characteristics and clinical significance. Patients with NHL who were newly diagnosed (NDP; n = 33), in remission (RMP; n = 28) and relapsed (RLP; n = 29) were included, and 47 volunteers were recruited as healthy controls (HCs). The frequency of CD10− neutrophils in the peripheral blood from HC and patients with NHL was detected. CD10− and CD10+ neutrophils were sorted, and their cytology was analyzed. CD3+ T cells were also isolated and cultured with the autologous CD10− or CD10+ neutrophils, after which the proliferation and death rates of T cells were determined. The levels of arginase‐1 (Arg‐1) and reactive oxygen species (ROS) in CD10+ or CD10− neutrophils were examined. Few CD10− neutrophils were detected in HCs but were significantly elevated in patients with NHL, especially in NDP and RLP. In addition, CD10− neutrophils in NDP with advanced stage and high risk were markedly higher than those in NDP with limited stage and low risk. In RMP and RLP, the relapse‐free survival and overall survival in patients with high CD10− neutrophils were shorter than those with low CD10− neutrophils. CD10− neutrophils from patients with NHL, which mainly consist of immature neutrophils, inhibit T‐cell proliferation and facilitate T‐cell death. Furthermore, a significant increase was observed in Arg‐1 expression, along with an increase to a certain extent in ROS. CD10− neutrophils in patients with NHL have characteristics of myeloid‐derived suppressor cells and may be related to disease progression and poor prognosis.
NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment
Authors: Li Fengqi , Wang Zhongyi , Zheng Dongpeng , Pang Zhaojun , Feng Chunjing , Ma Yue , Yang Ce , Li Xueren , Peng Shouchun , Liu Zichuan , Mu Xin 
Published: February 2024

AbstractNatural killer (NK) cell is a valuable tool for immunotherapy in cancer treatment, both the cultured cell line NK92 and primary NK cells are widely studied and used in research and clinical trials. Clinical observations witnessed the improvement of patients' NK cells in terms of cell counts and cytotoxic activity upon dasatinib treatment, an approved drug for chronic myeloid leukaemia and Ph+ acute lymphocytic leukaemia. Several studies supported the clinical observations, yet others argued a detrimental effect of dasatinib on NK cells. Due to the complex conditions in different studies, the definite influence of dasatinib on NK92 and primary NK cells remains to be settled. Here, we used a well‐defined in vitro system to evaluate the effects of dasatinib on NK92 cells and peripheral blood (PB)‐NK cells. By co‐culturing NK cells with dasatinib to test the cell counts and target cell‐killing activities, we surprisingly found that the chemical influenced oppositely on these two types of NK cells. While dasatinib suppressed NK92 cell proliferation and cytotoxic activity, it improved PB‐NK‐killing tumour cells. RNA sequencing analysis further supported this finding, uncovering several proliferating and cytotoxic pathways responding invertedly between them. Our results highlighted an intrinsic difference between NK92 and PB‐NK cells and may build clues to understand how dasatinib interacts with NK cells in vivo.
Transcriptomic analysis of Porphyromonas gingivalis‐infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker
Authors: Hamada Masakazu , Inaba Hiroaki , Nishiyama Kyoko , Yoshida Sho , Yura Yoshiaki , Matsumoto‐Nakano Michiyo , Uzawa Narikazu 
Published: February 2024

AbstractPeriodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), and Porphyromonas gingivalis, a major periodontal pathogen, has been identified as a specific and potentially independent microbial factor that increases the risk of cancer mortality. Gene expression in HNSCC due to P. gingivalis infection and how changes in gene expression affect the prognosis of HNSCC patients are not clarified. When P. gingivalis was cultured with HNSCC cells, it efficiently adhered to these cells and enhanced their invasive ability. A transcriptome analysis of P. gingivalis ‐infected HNSCC cells showed that genes related to migration, including CCL20, CITED2, CTGF, C8orf44‐SGK3, DUSP10, EGR3, FUZ, HBEGF, IL1B, IL24, JUN, PLAU, PTGS2, P2RY1, SEMA7A, SGK1 and SIX2, were highly up‐ or down‐regulated. The expression of up‐regulated genes was examined using the expression data of HNSCC patients obtained from The Cancer Genome Atlas (TCGA) database, and the expression of 5 genes, including PLAU, was found to be higher in cancer tissue than in solid normal tissue. An analysis of protein–protein interactions revealed that these 5 genes formed a dense network. A Cox regression analysis showed that high PLAU expression levels were associated with a poor prognosis in patients with TCGA‐HNSCC. Furthermore, the prognostic impact correlated with tumour size and the presence or absence of lymph node metastasis. Collectively, these results suggest the potential of PLAU as a molecular prognostic marker in HNSCC patients. Further in vivo and in vitro studies are needed to verify the findings of this study.
Comparison of efficacy and safety of tretinoin 0.05% and glycolic acid peeling 70% in axillary and neck lesions of acanthosis nigricans: A single‐blinded, randomized trial
Authors: Ghiasi Maryam , Samii Rana , Tootoonchi Nasim , Balighi Kamran , Heidari Sama 
Published: February 2024

AbstractBackgroundAcanthosis nigricans is a non‐inflammatory skin pigmentary disorder characterized by a dark, velvety appearance, primarily observed in the neck and axillary areas. It is commonly associated with obesity, diabetes, and insulin resistance. Although the primary treatment is correcting the underlying disorders, many aesthetic modalities have been established to improve appearance owing to cosmetic concerns.AimsWe aimed to compare and investigate the effectiveness and side effects of tretinoin 0.05% and glycolic acid 70% in treating acanthosis nigricans lesions of the axillary and neck area.MethodsThis single‐blinded, randomized trial recruited patients with neck or axillary involvement. Each patient was randomized to use cream tretinoin 0.05% every other night on one side, while the other side was treated with glycolic acid 70%, which was applied every 2 weeks at the clinic for four consecutive sessions. The study duration was 8 weeks, and patients were evaluated every 2 weeks based on their response to treatment, satisfaction, and side effects.ResultsThirty patients, including 14 with neck lesions and 16 with axillary lesions, were included. Tretinoin was significantly more effective for axillary lesions in terms of treatment response and patient satisfaction (p = 0.02 and p = 0.008, respectively). It was also shown that as the severity of the lesions increased, the response to treatment and patient satisfaction decreased, specifically when treating axillary lesions with glycolic acid (p = 0.02 and p = 0.03, respectively).ConclusionNeither method was significantly effective for neck lesions. However, tretinoin 0.05% was shown to be more efficacious in treating axillary lesions of acanthosis nigricans, despite causing minimal side effects.
Leverage Is a Double‐Edged Sword
Authors: SUBRAHMANYAM AVANIDHAR , TANG KE , WANG JINGYUAN , YANG XUEWEI 
Published: February 2024

ABSTRACTWe use proprietary data on intraday transactions at a futures brokerage to analyze how implied leverage influences trading performance. Across all investors, leverage is negatively related to performance, due partly to increased trading costs and partly to forced liquidations resulting from margin calls. Defining skill out‐of‐sample, we find that relative performance differentials across unskilled and skilled investors persist. Unskilled investors' leverage amplifies losses from lottery preferences and the disposition effect. Leverage stimulates liquidity provision by skilled investors, and enhances returns. Although regulatory increases in required margins decrease skilled investors' returns, they enhance overall returns, and attenuate return volatility.
Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation
Authors: Kemp Kate L. , Skinner Jazmine E. , Bertin François‐René 
Published: February 2024

AbstractBackgroundPhenylbutazone is often prescribed to manage pain caused by hyperinsulinemia‐associated laminitis, but in diabetic people nonsteroidal anti‐inflammatory drugs increase insulin secretion and pancreatic activity.Hypothesis/ObjectivesInvestigate the effect of phenylbutazone administration on insulin secretion in horses. It was hypothesized that phenylbutazone will increase insulin secretion in horses with insulin dysregulation (ID).AnimalsSixteen light breed horses, including 7 with ID.MethodsRandomized cross‐over study design. Horses underwent an oral glucose test (OGT) after 9 days of treatment with phenylbutazone (4.4 mg/kg IV q24h) or placebo (5 mL 0.9% saline). After a 10‐day washout period, horses received the alternative treatment, and a second OGT was performed. Insulin and glucose responses were compared between groups (ID or controls) and treatments using paired t test and analyses of variance with P < .05 considered significant.ResultsIn horses with ID, phenylbutazone treatment significantly decreased glucose concentration (P = .02), glucose area under the curve (2429 ± 501.5 vs 2847 ± 486.1 mmol/L × min, P = .02), insulin concentration (P = .03) and insulin area under the curve (17 710 ± 6676 vs 22 930 ± 8788 μIU/mL × min, P = .03) in response to an OGT. No significant effect was detected in control horses.Conclusion and Clinical ImportancePhenylbutazone administration in horses with ID decreases glucose and insulin concentrations in response to an OGT warranting further investigation of a therapeutic potential of phenylbutazone in the management of hyperinsulinemia‐associated laminitis beyond analgesia.
Paternal starvation affects metabolic gene expression during zebrafish offspring development and lifelong fitness
Authors: Jimenez‐Gonzalez Ada , Ansaloni Federico , Nebendahl Constance , Alavioon Ghazal , Murray David , Robak Weronika , Sanges Remo , Müller Ferenc , Immler Simone 
Published: February 2024

AbstractDietary restriction in the form of fasting is a putative key to a healthier and longer life, but these benefits may come at a trade‐off with reproductive fitness and may affect the following generation(s). The potential inter‐ and transgenerational effects of long‐term fasting and starvation are particularly poorly understood in vertebrates when they originate from the paternal line. We utilised the externally fertilising zebrafish amenable to a split‐egg clutch design to explore the male‐specific effects of fasting/starvation on fertility and fitness of offspring independently of maternal contribution. Eighteen days of fasting resulted in reduced fertility in exposed males. While average offspring survival was not affected, we detected increased larval growth rate in F1 offspring from starved males and more malformed embryos at 24 h post‐fertilisation in F2 offspring produced by F1 offspring from starved males. Comparing the transcriptomes of F1 embryos sired by starved and fed fathers revealed robust and reproducible increased expression of muscle composition genes but lower expression of lipid metabolism and lysosome genes in embryos from starved fathers. A large proportion of these genes showed enrichment in the yolk syncytial layer suggesting gene regulatory responses associated with metabolism of nutrients through paternal effects on extra‐embryonic tissues which are loaded with maternal factors. We compared the embryo transcriptomes to published adult transcriptome datasets and found comparable repressive effects of starvation on metabolism‐associated genes. These similarities suggest a physiologically relevant, directed and potentially adaptive response transmitted by the father, independently from the offspring's nutritional state, which was defined by the mother.
The experiences of ethical conflict among critical care professionals in China: A qualitative study
Authors: Liu Yuanfei , Zhang Yuping , Jin Jingfen 
Published: February 2024

AbstractBackgroundEthical conflict is embedded in healthcare and is common in critical care setting. However, there is a paucity of research on the nature of ethical conflict in China. Ethical conflict has cultural and context sensitivity. Therefore, evidence is needed from different backgrounds to help discuss this issue across borders.AimThis study aimed to qualitatively identify the experience of ethical conflict in critical care professionals in China.Study designFrom December 2021 to February 2022, we performed semi‐structured, face‐to‐face interviews with 21 critical care professionals from five intensive care units in a tertiary general hospital in China. A thematic analysis approach was used to analyse the data.ResultsFive themes and 14 sub‐themes emerged from the data. Critical care professionals probably felt unable to navigate uncertainty, torn by family issues, outraged by unprofessional behaviours of medical staff, being trapped in a socioeconomic dilemma when having experience of ethical conflict. In addition, they also perceived that they could turn struggle into growth.ConclusionsThe experience of ethical conflict in critical care professionals involved a mixture of feelings. This study builds a comprehensive understanding of how ethical conflict affected their perceptions of themselves and their profession and provides implications to develop effective coping strategies.Relevance to Clinical PracticeThe identification of critical care professionals' experience of ethical conflict would help identify what might trigger the ethical issues and what would be the potential target to optimize in critical practice.
Retracted: Polovchenko, Konstantin A. 2022. “The constitutional court as a subject of the political process.” Politics & Policy 50(3): 622–30. https://doi.org/10.1111/polp.12469
Authors: Polovchenko Konstantin A. 
Published: February 2024

AbstractThe above article published online on 23 May 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor, Emma Norman, and Wiley Periodicals LLC. Following concerns raised by a third party regarding manipulation of the peer review and publishing process, the editor and publisher investigated and found that the peer review process for this paper was compromised. As a result, the conclusions reported in the article are not considered reliable.