bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Impact of Various Endocrine Therapy Regimens on Mortality, Local Recurrence, and Metastasis in Breast Cancer: A 25-Year Retrospective Study
Authors: Khoddam Sadegh , Fattahi Mohammad Reza , Akbari Mohammad Esmaeil , Hossein Nezhad Aida , Izadi Neda , Akbari Atieh , Bakhshi Saeed , Dehghanbanadaki Hojat 
Published: February 2024

Background: This retrospective cohort study explores the long-term effects of different endocrine therapy regimens on mortality, local recurrence, and metastasis in breast cancer patients.
Methods: Data from the Referral Cancer Research Center of Shahid Beheshti University of Medical Sciences were analyzed. Records of 2,262 histologically confirmed breast cancer patients, with 25 years of follow-up were included. We collected patient data, including treatment modalities, and details of the endocrine therapy, and conducted statistical analysis to assess treatment-outcome associations.
Results: Patients had an average age of 49.45 years, and 99.1% were female. The average tumor size was 2.8 cm, with a 12.3% mortality rate. Positive expression of human epidermal growth factor receptor 2, progesterone receptor, and estrogen receptor was found in 17.3%, 71.8%, and 70.6% of patients, respectively. Tamoxifen was administered to 1,700 patients, letrozole to 715, and exemestane to 540, with an average endocrine therapy duration of 5.2 years. Letrozole treatment duration (P = 0.001) and lymph node involvement (P = 0.028) were independent predictive variables for local recurrence, with longer letrozole therapy associated with lower recurrence.
Conclusion: Estrogen receptor expression and endocrine therapy duration are independent predictive markers for recurrence and mortality. Longer letrozole therapy predicts lower local recurrence. Endocrine therapy duration inversely relates to mortality, recurrence, and local recurrence.
Exámenes de control de confianza: Su idoneidad en elementos de seguridad pública de la zona metropolitana de Guadalajara.
Authors: Navejas Padilla Ramón Gerardo , Orozco Torres Axel Francisco 
Published: February 2024

El presente tiene como objetivo describir la percepción de los exámenes de control y confianza en relación con la problemática de seguridad pública. Se utilizó un enfoque cualitativo, que permitió comprender el fenómeno y obtener una visión general.
Para recopilar los datos cualitativos, se realizaron entrevistas y observaciones directas, centrándose específicamente en expedientes de elementos que no lograron aprobar los exámenes de control y confianza. El análisis de datos se llevó a cabo mediante un proceso de categorización, para identificar y comprender las diferentes perspectivas recopiladas durante el estudio.
Los resultados revelaron desafíos y amenazas que enfrenta la seguridad pública, y las deficiencias en los procesos de control y confianza, que pueden conducir a la estigmatización, exclusión, desigualdades y discriminación.
En conclusión, se destaca la necesidad de contar con procesos sólidos en la materia, en lugar de simplemente confiar en estos exámenes carentes de fundamentos sólidos ante los procesos jurisdiccionales.
Refugio Climático y Justicia Global
Authors: Prieto Godoy Carlos Alberto , Fernández Reyes Pamela Lili 
Published: February 2024

El derecho internacional del refugiado, se ha caracterizado desde su convencionalización en Ginebra en 1951, por procurar protección internacional puntual a colectivos específicos que sufrieron persecución en la Europa de entre guerras. La protección internacional en sus diversas formas, se configura como un rasgo de alta estima, reflejo de los valores democráticos pactados por la comunidad de naciones, pues dicha institución simboliza el ánimo de los Estados, de resarcir el daño causado con la Segunda Guerra Mundial y el propósito de evitar su repetición. Para lo cual, se realizan declaraciones internacionales que reconocen los derechos humanos y la dignidad humana, como presupuesto básico de la paz. Se pretende el desarrollo económico, acabar con la miseria y el hambre, sin perder de vista dichos valores y principios. El calentamiento global y sus efectos, se configura como el gran reto del Siglo XXI. Hemos dado cuenta en este estudio, sobre la conexidad entre los efectos del cambio climático producto del calentamiento global, distintivo de la era del Antropoceno, con los desplazamientos masivos de personas; a su vez, ponemos de relieve la regulación internacional entre resquicios sobre el refugio climático, que revictimiza a las personas que sufren persecución por dichas razones.
Pengukuran dan Peningkatan Produktivitas Drafter Kontrak di PT X Oil Refinery Menggunakan Metode Objective Matrix (OMAX) dan Fishbone Diagram
Authors: Mirmaningtyas Dessy Cipta , Nurwathi Nurwathi 
Published: February 2024

Karyawan drafter di PT X Oil Refinery memiliki tugas membuat draft kontrak pengadaan jasa selama batas waktu pengerjaan 25 hari kerja. Berdasarkan pengamatan secara langsung drafter sedang mengalami permasalahan, yaitu tidak tercapainya target atau terjadi keterlambatan penyelesaian tugas kerja dari batas waktu yang sudah ditentukan, maka dilakukan penelitian analisis produktivitas menggunakan metode objective matrix (omax) dan perbaikan menggunakan fishbone diagram. Hasil perhitungan variabel kriteria produktivitas output sebanyak 1,640 unit/hari, produktivitas tenaga kerja 8,200 unit/orang, produktivitas perencanaan produksi 91%, produktivitas perencanaan waktu produksi 71%.. Nilai produktivitas terendah dimiliki oleh rasio 4 pada periode ke-10 dengan nilai skor 0,439. Rasio ini menunjukan produktivitas paling rendah terjadi pada periode k-10 karena jumlah draft kontrak yang dikerjakan jauh lebih banyak daripada periode sebelumnya. Kriteria produktivitas efisiensi yang menggambarkan penggunaan sumber daya menjadi permasalahan yang paling utama karena memiliki nilai bobot paling besar yaitu 196,9. Usulan perbaikan produktivitas untuk drafter, yaitu mengadakan penjadwalan trainning, menaikan standar syarat rekrutmen, mengikuti pelatihan dan pendidikan tentang kemampuan adaptif, menyediakan tata cara pengoperasian pada setiap mesin atau alat kantor yang baru, perusahaan melakukan pemantauan langsung cara rutin, memberikan intruksi yang jelas, dan mengubah SOP batas waktu pengerjaan draft.
Hubungan pengetahuan dengan Perilaku Penanganan Dishminorea pada remaja putri di SMP Telkom Sekar Kemuning Cirebon
Authors: Hidayah Fika Nurul 
Published: February 2024

Masa remaja merupakan masa perkembangan yang diawali dengan matangnya organ-organ fisik (seksual) sehingga mampu bereproduksi. Masa pubertas pada remaja putri ditandai dengan menstruasi yang seringkali disertai dengan rasa tidak nyaman berupa nyeri saat haid yang diikuti dengan rasa kram dan terpusat di abdomen bawah yang disebut dengan Dishminorea. Angka kejadian dismenore di Indonesia sebesar 64,52% yang terdiri dari 54,89% dismenore primer dan 9,36% dismenore sekunder. Sekitar 10% penderita dismenore tidak dapat melaksanakan aktivitas sehari-hari dan aktifitas belajar disekolah terganggu karena tidak dapat berkonsentrasi dengan baik. Tujuan penelitian ingin mengetahui hubungan pengetahuan dan dengan perilaku penanganan Dishminorea pada remaja di SMP Telkom Sekar Kemuning Cirebon. Penelitian ini merupakan penelitian analitik dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah seluruh siswi SMP Telkom Sekar Kemuning Sampel dalam penelitian ini menggunakan tehnik accidental sampling dengan jumlah 30 siswi. Hasil penelitian terdapat hubungan pengetahuan dengan perilaku penanganan Dishminorea pada remaja putri di SMP Telkom Sekar Kemuning Cirebon. Diharapkan agar remaja putri semakin meningkatkan kesadaran untuk mencari informasi terkait kesehatan reproduksi remaja
ANALISIS KEPUASAN KERJA TENAGA KESEHATAN DI RSUD ALIMUDDIN UMAR KABUPATEN LAMPUNG BARAT 2021
Authors: Tan'im Tan'im , Samino Samino , Yulyani Vera , Irianto Torry Duet 
Published: February 2024

Tenaga kesehatan sebagai sumber daya manusia (SDM) organisasi tempat mereka bekerja merupakan aset yang harus diberdayakan oleh karyawan yang bersangkutan maupun pihak organisasi, Persepsi dari beberapa tenaga kesehatan RSUD Alimudin Umar Kabupaten Lampung Barat yang merasa bahwa belum terpenuhinya kepuasan kerja. Berdasarkan hasil Survey Kepuasan Karyawan tahun 2020 diperoleh data dari 131 orang karyawan, sebanyak 57 orang (43,5%) menyatakan tidak puas dan sebanyak 74 orang (56,5%) menyatakan puas bekerja di RSUD Alimudin Umar Kabupaten Lampung Barat.Jenis penelitian ini menggunakan metode kuantitatif dengan rancangan cross sectional. Populasi seluruh tenaga kesehatan di RSUD sebanyak 131 orang yang berstatus Pegawai Negeri Sipil (PNS) dan sampel adalah total populasi data dikumpulkan dengan wawancara menggunakan kuesioner, Analisis data dilakukan dengan uji chi square dan regresi logistik. Hasil penelitian diperoleh ada hubungan kejelasan jasa medis (p-value = <0,001 dan OR = 5,89), kesesuaian jasa medis (p-value = <0,001 dan OR = 3,98), kepemimpinan (<0,001 dan OR = 8,28), kenyamanan kerja (p-value = 0,006 dan OR = 3,02) serta kelengkapan sarana dan prasarana kerja (p-value = <0,001 dan OR = 6,34) dengan kepuasan tenaga kesehatan di RSUD. Variabel kejelasan jasa medis, kesesuaian jasa medis, kepemimpinan, kenyamanan kerja, serta kelengkapan sarana dan prasarana kerja, merupakan faktor kepuasan tenaga kesehatan di RSUD. Kepemimpinan merupakan variable yang paling berhubungan dengan kepuasan tenaga kesehatan. Disarankan pimpinan RSUD harus terus melakukan pembinaan terhadap tenaga kesehatan sehingga tenaga kesehatan, melakukan pertemuan secara rutin setiap bulan untuk menyampaikan keberhasilan maupun permasalahan kepada tenaga kesehatan, meningkatkan sarana dan prasana, meningkatan supervise dan memberikan kepercayaan dan wewenang kepada tenaga kesehatan. Kata kunci: Kepuasa kerja, tenaga kesehatan
Differences in diameter and thickness of the seminiferous tubules of male wistar rats (rattus norvegicus) after being exposed to e-cigarette smoke and conventional cigarettes
Authors: Iring Atalya Riawani , Rambung Etha , Winarso Hudi 
Published: February 2024

Background: Electric cigarettes and conventional cigarettes have a detrimental effect on their users. Cigarettes contain ingredients that reduce the quality of male reproduction. Purpose: To determine the differences in diameter and thickness of the seminiferous tubules of male Wistar rats (rattus norvegicus) exposed to electric cigarettes compared to conventional cigarettes. Method: This research is a true experimental research in the laboratory using a post test-only control group design. The treatment group consisted of group K- as the negative control group, group K+ which was included in the smoking chamber but not exposed to cigarette smoke, group P1 which was included in the smoking chamber and exposed to electric cigarette smoke, group P2 which was included in the smoking chamber and exposed to conventional cigarette smoke. The treatment was carried out for 30 days and then testicular samples were taken to calculate diameter and thickness of the seminiferous tubules. Data were analyzed with SPSS using descriptive statistics and One Way ANOVA and Kruskall Wall is tests. Results: There was a decrease in the diameter and thickness of the seminiferous tubules in the treatment group which was significantly different from the control group. The results of the LSD post hoc test for differences in seminiferous tubule diameter between groups P1 and P2 were p=0.72 > 0.05. The results of the Mann Whitney test showed that the difference in seminiferous tubule thickness between groups P1 and P2 was p=0.06 > 0.05.Conclusion: Exposure to electric and conventional cigarettes caused changes in the diameter and thickness of the seminiferous tubules from normal conditions. There was no significant difference in the impact of exposure to electric and conventional cigarettes, maybe because the damage they produced was not different.
Lattice Boltzmann Simulation of Incompressible Fluid Flow in Two-sided Converging and Diverging Lid-driven Square Cavity
Authors: Yadav Mahendra , Singh Yadav Rajendra , Makinde Oluwole Daniel , Mathur Pankaj 
Published: February 2024

The present study focuses on the predictions of flow behavior, streamlines and some other factors of a two adjacent-sided converging and diverging lid-driven square cavity filled with fluid. In the diverging case, the top wall of the cavity is considered to be in motion from left to right, and the left wall is considered to be in motion from top to bottom simultaneously with identical speeds. It is found that for a low Reynolds number, the flow behavior seems to be symmetric with respect to one of the diagonals of the cavity, and at a critical Reynolds number 1121, the symmetry of the flow behavior blows up, and an asymmetric form is obtained due to the increased inertia and turbulence effects. Any increment in the Reynolds number above the critical Reynolds number develops this asymmetry gradually more and more. In the second phenomenon, the converging phenomenon, the top wall of the cavity is assumed to be in motion from left to right, and the right wall is assumed to be in motion from bottom to top simultaneously with identical speeds so that they converge at the corner of the cavity. This case gives rise to two critical Reynolds numbers Re = 969 and Re = 2053 and the flow behavior for both asymmetric states was found to be opposite. Furthermore, the rate of convergence of the present methodology, lattice Boltzmann methodology, for various Reynolds numbers is found to be very high except for the critical and their nearby Reynolds numbers.
Stereotactic Body Radiation Therapy (SBRT) Versus Transarterial Chemoembolization (TACE) for Treatment Of Hepatocellular Carcinoma: a Meta-Analysis of Propensity Matched Studies
Authors: Jia Sangyang , Lao Nicholas , Boldt R Gabriel , Mujoomdar Amol , Chow Ronald , Simone Charles , Lock Michael 
Published: February 2024

Introduction: There are currently limited data comparing the efficacy of stereotactic body radiation therapy (SBRT) to transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). The aim of this systematic review and meta-analysis was to report on the summary effect estimate of overall survival and local control at 1-year based on available evidence.
Methods: A literature search was conducted in PubMed from database inception until April 2020. Articles were independently screened by two reviewers and included if they reported on a propensity-matched study design comparing SBRT to TACE for the treatment of HCC with at least 1 year follow up. Event data of overall survival and local control at 1-year were extracted. A random-effects model was applied to generate summary odds ratio and corresponding 95% confidence intervals (CI).
Results: Four studies with 606 patients were identified and included. SBRT (73.6%) and TACE (67.0%) had similar 1-year rates of OS, with an OR of 0.87 (0.56, 1.37). SBRT (88.4%) had greater local control at 1 year compared to TACE (71.7%); OR of 0.34 (0.13, 0.86).
Conclusion: SBRT is comparable to TACE in terms of 1-year survival for the treatment HCC and may provide an advantage in terms of local control. Future controlled trials are necessary to determine the clinical advantages and best indications for each treatment.
Penerapan Model Problem Solving Untuk Meningkatkan Hasil Belajar Siswa Pada Muatan PKn Kelas II SDN Dinoyo 1 Kota Malang
Authors: Chusnul Chotimah  , Kardiana Metha Rozhana  , Olivia Tanggu Solo  
Published: February 2024

Tujuan penelitian untuk memperbaiki pola mengajar dan memperbaiki perilaku siswa dalam meningkatkan praktik proses belajar mengajar untuk memperoleh pengetahuan atau penemuan baru. Sebagai pembuktian tentang kebenaran dari pengetahuan yang sudah ada dan sebagai pengembangan pengetahuan suatu bidang keilmuan dalam pengambilan data. Metode penelitian yang digunakan yaitu deskriptif kualitatif dalam bentuk Penelitian Tindakan Kelas dengan teknik pengumpulan data yaitu observasi, teknik analisis data, dan teknik tes dalam siklus I dan Siklus II dengan subyek berjumlah 28 siswa. Penelitian ini dilakukan di SDN Dinoyo 1 Kota Malang dengan hasil menunjukkan bahwa pada siklus I ketuntasan hasil belajar siswa adalah 78,57% dan pada siklus II meningkat menjadi 96,42%. Hal ini menunjukkan bahwa hasil penelitian pada siklus II ini telah mencapai indikator keberhasilan.Hasil penelitian ini dapat disimpulkan bahwa melalui penggunaan model Problem Solving dalam proses belajar mengajar dapat meningkatkan hasil belajar PKn tentang Pancasila untuk siswa kelas II SDN Dinoyo 1 Kota Malang. Saran bagi guru agar selalu berinovasi dan merancangkan proses belajar mengajar yang menarik, salah satu caranya dengan menggunakan model Problem Solving dalam proses pembelajaran di kelas. Bagi sekolah berdasarkan hasil penelitian ini sekolah diharapkan dapat menggunakannya sebagai bahan acuan untuk mengembangkan kualitas proses belajar mengajar. Bagi peneliti selanjutnya di sarankan untuk melakukan penelitian ini dengan subjek yang berbeda, agar diperoleh hasil penelitian yang lebih luas dan bermanfaat sebagai bahan informasi bagi dunia pendidikan.
TSE-GAN: strain elastography using generative adversarial network for thyroid disease diagnosis
Authors: Song Anping , Li Tianyi , Ding Xuehai , Wu Mingye , Wang Ren 
Published: February 2024

Over the past 35 years, studies conducted worldwide have revealed a threefold increase in the incidence of thyroid cancer. Strain elastography is a new imaging technique to identify benign and malignant thyroid nodules due to its sensitivity to tissue stiffness. However, there are certain limitations of this technique, particularly in terms of standardization of the compression process, evaluation of results and several assumptions used in commercial strain elastography modes for the purpose of simplifying imaging analysis. In this work, we propose a novel conditional generative adversarial network (TSE-GAN) for automatically generating thyroid strain elastograms, which adopts a global-to-local architecture to improve the ability of extracting multi-scale features and develops an adaptive deformable U-net structure in the sub-generator to apply effective deformation. Furthermore, we introduce a Lab-based loss function to induce the networks to generate realistic thyroid elastograms that conform to the probability distribution of the target domain. Qualitative and quantitative assessments are conducted on a clinical dataset provided by Shanghai Sixth People’s Hospital. Experimental results demonstrate that thyroid elastograms generated by the proposed TSE-GAN outperform state-of-the-art image translation methods in meeting the needs of clinical diagnostic applications and providing practical value.
Individual learning paths mastering teachers’ professional vision
Authors: Oellers Manuel , Junker Robin , Holodynski Manfred 
Published: February 2024

IntroductionPromoting a professional vision of teaching as a key factor of teachers’ expertise is a core challenge for teacher professionalization. While research on teaching has evolved and successfully evaluated various video-based intervention programs, a prevailing emphasis on outcome measures can yet be observed. However, the learning processes by which teachers acquire professional vision currently remain a black box. The current study sought to fill this research gap. As part of a course dedicated to promoting a professional vision of classroom management, students were imparted knowledge about classroom management that had to be applied to the analysis of authentic classroom videos. The study aimed to determine the variety of individual strategies that students applied during their video analyses, and to investigate the relationship between these and the quality of the students’ analyses, measured by their agreement with an experts’ rating of the video clips.MethodsThe sample comprised 45 undergraduate pre-service teachers enrolled in a course to acquire a professional vision of classroom management. By applying their imparted knowledge of classroom management, students engaged in the analysis of classroom videos to learn how to notice and interpret observable events that are relevant to effective classroom management. Implementing a learning analytical approach allowed for the gathering of process-related data to analyze the behavioral patterns of students within a digital learning environment. Video-based strategies were identified by conducting cluster analyses and related to the quality of the students’ analysis outcomes, measured by their concordance with the experts’ ratings.ResultsWe gained insight into the learning processes involved in video-based assignments designed to foster a professional vision of classroom management, such as the areas of interest that attracted students’ heightened attention. We could also distinguish different approaches taken by students in analyzing classroom videos. Relatedly, we found clusters indicating meticulous and less meticulous approaches to analyzing classroom videos and could identify significant correlations between process and outcome variables.DiscussionThe findings of this study have implications for the design and implementation of video-based assignments for promoting professional vision, and may serve as a starting point for implementing process-based diagnostics and providing adaptive learning support.
Value of markers of systemic inflammation for the prediction of postoperative progression in patients with pancreatic neuroendocrine tumors
Authors: Yang Liu , Fu Mengfei , Yu Li , Wang Hanyu , Chen Xiao , Sun Hui 
Published: February 2024

BackgroundNon-invasive prognostic predictors for rare pancreatic neuroendocrine tumors (PNETs) are lacking. We aimed to approach the prognostic value of preoperative systemic inflammatory markers in patients with PNETs.MethodsThe clinical data of 174 patients with PNETs undergoing surgical treatment were retrospectively analyzed to explore the correlation of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and platelet to white blood cell ratio (PWR) with clinicopathological parameters and the progression of tumor after the operation. The optimal cutoff values for predictors and the area under the curve (AUC) of the receiver operating characteristic (ROC) were estimated. Univariate and multivariate Cox proportional hazards models were used to assess the relation between NLR, LMR, PLR, and progression-free survival (PFS), examined by the Kaplan–Meier and log-rank tests.ResultsThe scores of the NLR (P = 0.039) and PLR (P = 0.011) in the progression group were significantly higher than those in the progression-free group, and the LMR was significantly lower than those in the progression-free group (P = 0.001). The best cutoff values of NLR, LMR, and PLR before operation were 2.28, 4.36, and 120.91. The proportions of tumor progression in the high NLR group (P = 0.007) and high PLR group (P = 0.013) obviously increased, and the proportion of tumor development in the low LMR group was higher than that in the high LMR group (P &lt; 0.001). The K-M survival curve showed that the progression-free survival rate was lower in the high NLR group (P = 0.004), the low LMR group (P &lt; 0.001), and the high PLR group (P = 0.018). The results of the multivariate Cox proportional hazards model suggested that preoperative LMR (HR = 3.128, 95% CI: 1.107~8.836, P = 0.031) was an independent predictor of PFS.ConclusionThe markers of systemic inflammation, especially LMR, can predict the postoperative progression of PNETs.