bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olink Proteomics Platform Reveals Serum Inflammatory Related Protein Biomarkers in Abdominal Aortic Aneurysms
Authors: Zhang Ruijing , Chang Runze , Wang Heng , Chen Jinshan , Yan Sheng , Li Yaling , Xuan Xuezhen , Qiao Maolin , Gao SiQi , Li Lizheng , Lu Chuanlong , Fan Keyi , Dong Honglin 
Published: February 2024

Abstract
Abdominal aortic aneurysm is a cardiovascular disease associated with chronic inflammation that poses a serious threat to the population. This study used the emerging Olink proteomics technology with the aim of identifying markers associated with inflammation in the serum of patients with abdominal aortic aneurysm. Serum samples were collected from 14 patients with abdominal aortic aneurysms on the day of admission to the hospital and serum samples from 14 healthy individuals were used as controls. The expression levels of 92 inflammation-related proteins were compared between abdominal aortic aneurysm patients (n=8) and controls (n=8) using the Olink Proximity Extension Assay inflammation plate. Differential proteins were analyzed by enrichment analysis and ROC curve analysis to determine their role and value in the diagnosis and study of abdominal aortic aneurysms. Subsequently, five proteins were screened for ELISA validation by correlation analysis between differential proteins and the maximum diameter of abdominal aortic aneurysms in combination with expression differences and diagnostic value. The results of the study showed that 26 proteins were upregulated in expression in the abdominal aortic aneurysm group compared with the control group, and the selected FGF-19, CCL11, TNFRSF9, FGF-21, and IL-12B were validated by ELISA. The results showed that these five proteins were up-regulated in the serum of abdominal aortic aneurysm patients（P<0.05）, which may be novel diagnostic markers for abdominal aortic aneurysm disease.
Impact of work and working conditions on Low Back Pain among fisher women: A cross sectional study in Trivandrum
Authors: Rahim Jazeela Abdul , Kannan Srinivasan , Rajagopalan Harini 
Published: February 2024

Abstract
Objective: To estimate the prevalence of Chronic Low Back Pain, its severity and associated factors among fisherwomen.
Methods: Cross-sectional survey conducted among 336 fisherwomen aged 18-49 years from 7 fishing villages in Trivandrum. The prevalence of Chronic Low Back Pain estimated using Nordic Body Map. Pain severity was assessed using the Pain Numeric Rating Scale.
Results: Prevalence of chronic low back pain was 45%. High BMI, UTI history, stress-induced headaches, falls, physical abuse, water-collection frequency, work-experience, and standing duration were associated with chronic low back pain. The Pain severity prevalence was 23.8% mild, 51.65% moderate and 24.5% severe. Income, continuous-standing, improper-seating, and stipulated rest-time were associated with seventy of Chronic Low Back Pain. Standing continuously and improper seating were predictors of pain severity.
Conclusion: Low back pain is common among fisherwomen contributed by work-related behavior. Posture correction measures such as educating the fisherwomen on appropriate posture and need for relaxation will improve their health conditions. Improved working environments which include proper resting place, designated space for vending with proper seating arrangement with chairs and with back support will improve the LBP status of fisherwomen.
Halothane sedation with local anesthesia as a bailout procedure for neonate with subglottic stenosis and post-MMC repair defect for O-Z flap: a case report
Authors: Shimekit Mikael Aseged , Eshetie Zemed Geleta , Lemma Mahlet Getachew 
Published: February 2024

Abstract
Introduction:
Subglottic stenosis (SGS) can develop after intubation in children. With mild subglottic stenosis, children can be asymptomatic. Endotracheal intubation is difficult in infants with subglottic stenosis. Here is a case of subglottic stenosis in infant planned for flap wound closure managed with sedation.
Case presentation:
A 1 month-old infant for whom thoracolumbar myelomeningocele (MMC) was repaired during her 2nd week of life, then she developed a wound infection on the 4th postoperative day, and after 2 weeks she was scheduled for a wound closure. However, intubation was difficult and rescheduled but with the senior anesthesiologist it was not possible to intubate and after discussion with an anesthesiologist sedation and local anesthesia was used to proceed with wound closure with a flap.
Conclusion
sedation with local anesthesia can be used for neonates and infants with subglottic stenosis when intubation is difficult.
Arsitektur Vernakular yang Mendukung Pembangunan Berkelanjutan di Kampung Adat Tamkesi Kabupaten Timor Tengah Utara
Authors: Tanggela Stephani Jecquelin Daindo , Bawole Paulus 
Published: February 2024

Title: Vernacular Architecture that Supports Sustainable Development in the Tamkesi Traditional Village, North Central Timor Regency
Indonesia has a wealth of diverse vernacular architecture. Still, in this era of openness to information and outside cultures, it seems the uniqueness of this architecture has become neglected and threatened with loss. Amid the external-internal influences that cause changes in the archipelago's vernacular buildings, the Atoni tribe in the Tamkesi traditional village responds otherwise. This paper examines how the indigenous Atoni people maintain the authenticity and sustainability of the Tamkesi traditional village, its architecture, and their involvement in sustainable development. This research uses descriptive qualitative research methods, while analysis techniques are carried out by coordinating data collection techniques through books, journals, articles, and an understanding of the theory of vernacular architecture and sustainable development. Based on the results of the analysis show that the Tamkesi traditional village is one of the oldest villages on the island of Timor, East Nusa Tenggara, which is still sustainable today and has developed from generation to generation based on the concept of local cultural wisdom and harmonization with nature.
Optimal valve closing law for improved water hammer control: a case from a water supply pipeline in Guelma, Algeria
Authors: Toumi Abdelouaheb , Sekiou Fateh 
Published: February 2024

Abstract

Finding the most suitable closing law is essential to decrease the shock wave pressure caused by transient flow and minimize the potential damage to equipment. The closure of a valve can occur instantly, rapidly, or gradually, and the appropriate law can be convex, linear, or concave, depending on various factors. These factors include the pipe's characteristics (type, diameter, roughness, and length), the conveyed fluid (nature and temperature), and operating conditions (pressure and flow rate). Other factors that receive less attention, such as the duration of slow closure and the impact of soil load on the pipe, are also considered in this study. The main focus of this article is to investigate how the optimal law evolves based on the time it takes for a valve to gradually close, specifically in the case of a valve located at the end of an underground gravity supply pipe. The findings reveal that when the slow closure time (t) exceeds 0.50 times the return period (t4), the exponent of the optimal law becomes a damped periodic function. Each closure time corresponds to a unique optimal law, and as the valve closure time increases, the range of optimal laws becomes narrower.
Discharge formula based on brink depth over sharp-crested weirs
Authors: Alomari Nashwan K. , Khaleel Moayad S. , Mohammed Ahmed Y. , Juma Inaam A. 
Published: February 2024

Abstract
Weirs are among the most essential hydraulic structures for measuring water discharge in open channels. The prediction of water discharge over weirs should be as precise and straightforward measured as feasible. The experimental investigation of flow prediction over varied heights of a conventional rectangular sharp-crested weir was conducted in the present work. The investigation evaluated five ratios of weir height to length, P/b, of 0.33, 0.4, 0.47, 0.53, and 0.6, different water discharges, Q, of up to 17.25 L/s, and different bed slopes, S, between 0.001 and 0.01. The experiment's findings reveal that a change in the bed slope has no significant effect on the brink depth, hb, for a constant water discharge. However, it influences the head over the weir, h, which is usually measured upstream of the weir location and used to predict water discharge. A simple, accurate formula was developed for predicting water discharge over rectangular sharp-crested weirs depending on the brink depth with mean absolute percent error (MAPE) and root-mean-square error (RMSE) of 1.714% and 0.229, respectively. In addition to having a simple form, the developed formula performs well, is unaffected by the bed slope, and applies to a wide range of h/P values, from 0.158 to 0.945.
Occurrence and ecological risk of PAHs in urban road runoff in Beijing
Authors: Zhang Xiaoran , Ji Hongming , Yan Lei , Liu Junfeng , Wang Shiyu , Zhang Ziyang , Tan Chaohong , Li Haiyan , Hu Yuansheng 
Published: February 2024

Abstract

The occurrence and ecological risks of 16 polycyclic aromatic hydrocarbons (PAHs) in different types of urban road runoff in Beijing during two typical rainfall events were studied. The average concentration of PAHs in road runoff particulate was in the order of Guanyuanqiao Road (ring road, 15,175 ng/L) &gt; Huayuanqiao Road (primary road, 4,792 ng/L) &gt; Dongcheng Alley (alley, 4,774 ng/L) &gt; Nansihuan Viaduct (viaduct, 770 ng/L), much higher than dissolved PAHs. The total concentration of ∑16PAHs decreased with runoff scouring. Rainfall conditions and the accumulation of PAHs in the early rainfall period show a significant impact on PAHs pollution. The event mean concentration range of PAHs is 674–21,596 ng/L, following in the order of ring road &gt; primary road &gt; alley &gt; viaduct. The proportion of four-ring PAHs was the highest. The first flush effect of PAHs is found in both rainfall events, and the effect of different ring PAHs is relatively similar. The content of PAHs is positively correlated with the amount of total organic carbon and suspended substance in runoff (r2&gt; 0.72). The ecological risk assessment indicated that PAHs in road runoff except viaduct road corresponded to high risk.
Uremic Toxins Elimination from Simulated Intestinal Serum with Mesoporous Silica Nanoparticles Coupled with Molecularly Imprinted Polymers and Amino Linker
Authors: Nazmi Miardan Leila , Rezaii Ebrahim , Mahkam Mehrdad , Khosroshahi Hamid Tayebi 
Published: February 2024

Background:
One of the most researched issues is the elimination of uremic toxins from the human body. These toxins can build up and lead to catastrophic issues including renal failure. To get rid of them, absorbents like activated carbon, zeolites, and other minerals are frequently utilized.

Methods:
Mesoporous silica nanoparticles functionalized with (3-Aminopropyl) triethoxysilane (APTES) linker (MSN-NH2) and mesoporous silica nanoparticles grafted with molecularly imprinted polymers (MSN-MIP) from the previous study were examined in this study to determine how well they absorbed urea, creatinine, and uric acid in a simulated intestinal serum.

Results:
MSN-MIP's large surface area (879.12 (m2/g)) and volume of pores (0.8475 (cm3/g)) made removal results that were satisfactory in the simulated serum. Additionally, MSN-MIP demonstrated a high urea adsorption capacity (qm = 1836.45 mg/g). Creatinine (qm = 1529.5 mg/g) and uric acid (qm = 1210.6 mg/g) were absorbed via NH-MSN2, which demonstrated a noticeable potential for absorption. The results of cell viability test for the first 72 hours, showed that the use of these absorbents in hemodialysis systems is acceptable.

Conclusion:
Synthesized adsorbents can be utilized in the hemodialysis system since the results of the cell viability test also showed that the percentage of cell viability was extremely high up to 72 hours.
Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus
Authors: Samsudeen Haajeera , De Varaj Shree Pavithra , Kandasamy Krishnaveni 
Published: February 2024

Background:
Millions of people worldwide are affected by the serious consequences
of diabetes mellitus, which is a major global health concern. We analyze the possibility of muscle-
strengthening activities as an appropriate therapeutic strategy for controlling the progression
of diabetes mellitus in this comprehensive review. In this review, we explore the molecular processes
underlying the glucose uptake in skeletal muscle, revealing how exercise can improve insulin
sensitivity and glucose homeostasis.

Methodology:
Articles published between 2010 and 2023 were analyzed in detail by using bibliographic
databases like PubMed, Medline, and Scopus. The most commonly searched terms
were "muscle strengthening exercises," "diabetes mellitus," "insulin resistance," "glucose uptake,"
"skeletal muscle," and even "exercise therapy." The inclusion criteria were randomized
controlled trials, observational studies, and systematic reviews. This allowed for the selection of
sources that were related to the topic at hand and were reliable.

Results:
This review highlights the benefits of exercise for diabetes mellitus, elucidating the positive
effects of acute and regular exercise on glucose uptake in skeletal muscle. It also analyzes
the impact of various exercise modalities, including aerobic and resistance exercises, on glucose
metabolism in individuals with and without type 2 diabetes. Furthermore, this review examines
the effectiveness of combining aerobic and resistance training for optimal diabetes management.

Conclusion:
Our analysis reveals promising evidence supporting the role of resistance training
in diabetes mellitus reversal. Regular resistance exercise has been shown to improve glycemic
control, insulin sensitivity, and muscle function in individuals with type 2 diabetes. Combining
aerobic and resistance exercises appears to be more effective than single-mode training in managing
blood glucose levels and enhancing overall metabolic health. However,
Resistance training implementation challenges, as well as potential exercise contraindications in
diabetic patients, warrant further studies.
Xanthine Oxidoreductase in the Pathogenesis of Endothelial Dysfunction: An Update
Authors: Mudgal Rajat , Singh Sanjiv 
Published: February 2024

Abstract:Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in the formation of uric acid (UA) and is involved in the generation of reactive oxygen species (ROS). Overproduction of ROS has been linked to the pathogenesis of hypertension, atherosclerosis, and cardiovascular disease, with multiple studies over the last 30 years demonstrating that XOR inhibition is beneficial. The involvement of XOR and its constituents in the advancement of chronic inflammation and ROS, which are responsible for endothelial dysfunction, is the focus of this evidence-based review. An overabundance of XOR products and ROS appears to drive the inflammatory response, resulting in significant endothelium damage. It has also been demonstrated that XOR activity and ED are connected. Diabetes, hypertension, and cardiovascular disease are all associated with endothelial dysfunction. ROS mainly modifies the activity of vascular cells and can be important in normal vascular physiology as well as the development of vascular disease. Suppressing XOR activity appears to decrease endothelial dysfunction, probably because it lessens the generation of reactive oxygen species and the oxidative stress brought on by XOR. Although there has long been a link between higher vascular XOR activity and worse clinical outcomes, new research suggests a different picture in which positive results are mediated by XOR enzymatic activity. Here in this study, we aimed to review the association between XOR and vascular endothelial dysfunction. The prevention and treatment approaches against vascular endothelial dysfunction in atherosclerotic disease.
Immunoinformatic Analysis of Leishmania Major gp46 Protein and
Potential Targets for Vaccination against Leishmaniasis
Authors: Hafezi Ahmadi Mohammad Reza , Mamizadeh Mina , Siamian Davood , Touyeh Mehdi Ali Asghari , Shams Morteza , Rashidi Yasaman 
Published: February 2024

Background:
Cutaneous leishmaniasis (CL) is a parasitic disease with a significant
burden in the Old World countries.

Objective:
In the current study, some of the primary biochemical properties and IFN-γ inducing
epitopes with specific binding capacity to human and mouse MHC alleles were predicted for
Leishmania major gp46 antigenic protein.

Methods:
Several online servers were used to predict physico-chemical traits, allergenicity, antigenicity,
transmembrane domain and signal peptide, subcellular localization, post-translational
modifications (PTMs), secondary and tertiary structures, tertiary model refining with validations.
Also, IEDB web server was used to predict mouse/human cytotoxic T-lymphocyte (CTL)
and helper T-lymphocyte (HTL) epitopes.

Results:
The 33.25 kDa protein was stable, hydrophilic, antigenic, while non-allergenic, with
enhanced thermotolerance and 45 PTM sites. The secondary structure encompassed a random
coil, followed by extended strands and helices. Ramachandran-based analysis of the refined
model showed 73.1%, 21.6%, 3.4% and 1.9% of residues in the most favored, additional allowed,
generously-allowed and disallowed regions, respectively. Epitope screening demonstrated
4 HTL epitopes against seemingly protective HLA alleles, 5 HTL epitopes against the HLA
reference set, 3 human CTL epitopes and a number of mouse MHC-restricted epitopes.

Conclusion:
This paper provides insights into the bioinformatics characteristics of the L. major
gp46 protein as a promising vaccine candidate.
Factors Associated With Perception of Stigma Among Parents of Children With Cleft Lip and Palate: Cross-Sectional Study
Authors: Zhang Yanan , Zhang Xinwen , Jiang Jinzhuo , Xie Wanhua , Xiang Daoman 
Published: February 2024

Background
Parents of children with cleft lip with or without cleft palate (CL/P) often face stigmatization, which has a significant impact on their quality of life and mental health. However, to date, there is a lack of comprehensive, multicenter empirical research on parents of children with CL/P in China, particularly those with large-scale samples.

Objective
This study aimed to identify major factors that contribute to the perception of stigma experienced by parents of children with CL/P.

Methods
A cross-sectional survey was conducted. A total of 104 parents of children diagnosed with CL/P in 2 hospitals were selected by convenience sampling. Demographics and disease information, the Chinese Perception of Stigma Questionnaire, the Center for Epidemiological Studies Depression Scale, and the Social Anxiety Scale were used in this study. Descriptive statistics, t tests, and one-way ANOVA were used to compare the differences between participants’ demographic information and perception of stigma. Multivariable linear regression was performed to assess associations between demographic factors, social anxiety, depression, and perception of stigma.

Results
The mean scores for the dimensions of perception of stigma, depression, and social anxiety were 22.97 (SD 9.21), 38.34 (SD 8.25), and 22.86 (SD 6.69), respectively. Depression and social anxiety were positively associated with discrimination, while surgery status was a negatively associated variable. Parents with a college education or higher had significantly lower levels of perceived stigma compared to parents with a junior high school education (all P values <.05). These 4 factors explained 40.4% of the total model variance (F8=9.726; P<.001; R2=0.450; adjusted R2=0.404).

Conclusions
Our findings highlight a concerning trend of diminished quality of life among parents of children with CL/P. Factors such as parents’ education level, surgery status, depression, and social anxiety are shown to influence the level of stigma experienced. Implementing comprehensive nursing care and providing presurgical support are effective strategies for alleviating parents’ social anxiety, reducing perceived stigma, and preventing depression.
IMPLEMENTASI LEAN SIX SIGMA UNTUK MENURUNKAN VARIASI DAN WAKTU PROSES PENGADAAN OBAT DI INSTALASI FARMASI RUMAH SAKIT ISLAM AMAL SEHAT SRAGEN
Authors: Gwen Meyta Radhila , Erna Kristin  , Firman  
Published: February 2024

Background: Drug management needs to be done to prevent stock out, over stock, and drug purchases due to emergency conditions. Reports of drug management problems at Amal Sehat Sragen Hospital are stock outs resulting in immediate drug purchases and patients do not get the drug as they should. Lean Six Sigma combines two methodologies to help speed up certain processes so they can solve problems faster while creating more value for customers. When combined, these create a powerful methodology for managing a business and completing tasks on time, on budget, saving money, adding value and increasing productivity.
Objectives: Assessing the implementation of Lean Six Sigma to reduce variation and processing time for drug procurement at the Pharmacy Installation of Amal Sehat Sragen Hospital.
Methods: The method used in this study is a mixed methods with a Participatory Action Research (PAR) approach.
Results: The results of the sample data that has variations and processing time are correlated with criticality, cost, and performance values to obtain Importance Index (II) values. Calculation of Importance Index (II), before implementation, 3 items with high Importance Index (II) values were obtained, namely "Gabapentin 300mg" (8.7), "Metformin 500mg (11.8), and "Lisinopril 5mg" (10.7) which decreased after implementation to “Gabapentin 300mg” (4.5), “Metformin 500mg (3.2), and “Lisinopril 5mg” (5.3). Assessment of the effectiveness and efficiency of drug procurement by measuring the lead time in cycle I was 9 days 23 hours 25 minutes, decreasing to 4 days 7 hours 50 minutes in cycle III. The efficiency measure based on the Value-added ratio (VAR) in cycle I was 14% and increased to 34% in cycle III.
Conclusions: The implementation of Lean Six Sigma with DMAIC (Define, Measure, Analyze, Improve, Control) and Participatory Action Research approaches (three cycles) was able to reduce variations in the drug procurement process (critical criteria, performance, and cost) and overall lead time in the drug procurement process at Amal Sehat Sragen Hospital.