bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of early bladder outcomes after spinal cord injury: The HALT score
Authors: Wu Xiangbo , Xi Xiao , Xu Mulan , Gao Ming , Liang Ying , Sun Miaoqiao , Hu Xu , Mao Li , Liu Xingkai , Zhao Chenguang , Sun Xiaolong , Yuan Hua 
Published: February 2024

AbstractAimsNeurogenic bladder (NB) is a prevalent and debilitating consequence of spinal cord injury (SCI). Indeed, the accurate prognostication of early bladder outcomes is crucial for patient counseling, rehabilitation goal setting, and personalized intervention planning.MethodsA retrospective exploratory analysis was conducted on a cohort of consecutive SCI patients admitted to a rehabilitation facility in China from May 2016 to December 2022. Demographic, clinical, and electrophysiological data were collected within 40 days post‐SCI, with bladder outcomes assessed at 3 months following SCI onset.ResultsThe present study enrolled 202 SCI patients with a mean age of 40.3 ± 12.3 years. At 3 months post‐SCI, 79 participants exhibited complete bladder emptying. Least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression analyses identified the H‐reflex of the soleus muscle, the American Spinal Injury Association Lower Extremity Motor Score (ASIA‐LEMS), and the time from lesion to rehabilitation facility (TLRF) as significant independent predictors for bladder emptying. A scoring system named HALT was developed, yielding a strong discriminatory performance with an area under the receiver operating characteristics curve (aROC) of 0.878 (95% CI: 0.823–0.933). A simplified model utilizing only the H‐reflex exhibited excellent discriminatory ability with an aROC of 0.824 (95% CI: 0.766–0.881). Both models demonstrated good calibration via the Hosmer–Lemeshow test and favorable clinical net benefits through decision curve analysis (DCA). In comparison to ASIA‐LEMS, both the HALT score and H‐reflex showed superior predictive accuracy for bladder outcome. Notably, in individuals with incomplete injuries, the HALT score (aROC = 0.973, 95% CI: 0.940–1.000) and the H‐reflex (aROC = 0.888, 95% CI: 0.807–0.970) displayed enhanced performance.ConclusionTwo reliable models, the HALT score and the H‐reflex, were developed to predict bladder outcomes as early as 3 months after SCI onset. Importantly, this study provides hitherto undocumented evidence regarding the predictive significance of the soleus H‐reflex in relation to bladder outcomes in SCI patients.
Molnupiravir: Mechanism of action, clinical, and translational science
Authors: Maas Brian M. , Strizki Julie , Miller Randy R. , Kumar Sushma , Brown Michelle , Johnson Matthew G. , Cheng Mickie , De Anda Carisa , Rizk Matthew L. , Stone Julie A. 
Published: February 2024

AbstractMolnupiravir is an oral prodrug of the broadly active, antiviral ribonucleoside analog N‐hydroxycytidine (NHC). The primary circulating metabolite NHC is taken up into cells and phosphorylated to NHC‐triphosphate (NHC‐TP). NHC‐TP serves as a competitive substrate for viral RNA‐dependent RNA polymerase (RdRp), which results in an accumulation of errors in the viral genome, rendering virus replication incompetent. Molnupiravir has demonstrated activity against SARS‐CoV‐2 both clinically and preclinically and has a high barrier to development of viral resistance. Little to no molnupiravir is observed in plasma due to rapid hydrolysis to NHC. Maximum concentrations of NHC are reached at 1.5 h following administration in a fasted state. The effective half‐life of NHC is 3.3 h, reflecting minimal accumulation in the plasma following twice‐daily (Q12H) dosing. The terminal half‐life of NHC is 20.6 h. NHC‐TP exhibits a flatter profile with a lower peak‐to‐trough ratio compared with NHC, which supports Q12H dosing. Renal and hepatic pathways are not major routes of elimination, as NHC is primarily cleared by metabolism to uridine and cytidine, which then mix with the endogenous nucleotide pools. In a phase III study of nonhospitalized patients with COVID‐19 (MOVe‐OUT), 5 days of treatment with 800 mg molnupiravir Q12H significantly reduced the incidence of hospitalization or death compared with placebo. Patients treated with molnupiravir also had a greater reduction in SARS‐CoV‐2 viral load and improved clinical outcomes, compared with those receiving placebo. The clinical effectiveness of molnupiravir has been further demonstrated in several real‐world evidence studies. Molnupiravir is currently authorized or approved in more than 25 countries.
Erythropoiesis and estimated fluid volume regulation following initiation of ipragliflozin treatment in patients with type 2 diabetes mellitus and chronic kidney disease: A post‐hoc analysis of the PROCEED trial
Authors: Maruhashi Tatsuya , Tanaka Atsushi , Takahashi Kanae , Higashi Yukihito , Node Koichi ,   the PROCEED trial investigators
Published: February 2024

AbstractAimsTo analyse the changes in erythropoietic and estimated fluid volume parameters after the initiation of ipragliflozin, a sodium‐glucose co‐transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD).MethodsThis was a post‐hoc analysis of the PROCEED trial, which evaluated the effect of 24‐week ipragliflozin treatment on endothelial dysfunction in patients with T2DM and CKD. We evaluated the changes in erythropoietic and estimated fluid volume parameters from baseline to 24 weeks post‐treatment in 53 patients who received ipragliflozin (ipragliflozin group) and 55 patients with T2DM and CKD without sodium‐glucose co‐transporter 2 inhibitors (control group), a full analysis set of the PROCEED trial.ResultsThe increases in haemoglobin [estimated group difference, 0.5 g/dl; 95% confidence interval (CI), 0.3‐0.8; p < .001], haematocrit (estimated group difference, 2.2%; 95% CI, 1.3‐3.1; p < .001) and erythropoietin (estimated log‐transformed group difference, 0.1; 95% CI, 0.01‐0.3; p = .036) were significantly greater in the ipragliflozin group than those in the control group. Ipragliflozin treatment was significantly associated with an increase in erythropoietin, independent of the corresponding change in haemoglobin (β = 0.253, p < .001) or haematocrit (β = 0.278, p < .001). Reductions in estimated plasma volume (estimated group difference, −7.94%; 95% CI, −11.6 to −4.26%; p < .001) and estimated extracellular volume (estimated group difference, −181.6 ml; 95% CI, −275.7 to −87.48 ml; p < .001) were significantly greater in the ipragliflozin group than those in the control group.ConclusionsErythropoiesis was enhanced and estimated fluid volumes were reduced by ipragliflozin in patients with T2DM and CKD.Clinical trialPROCEED trial (registration number: jRCTs071190054).
Development and validation of a prospective questionnaire for assessing oily sensitive skin
Authors: Zhang Jiaqi , Zhou Yi , Zhou Fangni , Li Xiang , Lu Ying , Wu Fan , Han Yuqing , Liu Qi , Chang Sisi , Zhu Wenjing , Li Bing , Pan Yao 
Published: February 2024

AbstractBackgroundSkin type has a strong influence on how sensitive skin develops, with oily skin accounting for a larger proportion of sensitive skin. However, there has not been a scientifically sound questionnaire for determining oily sensitive (OS)‐type skin in prior studies.ObjectivesIn order to identify OS‐type skin in the general population, we therefore intend to create an OS‐type skin evaluation questionnaire, develop various thresholds through data analysis and classify skin based on two dimensions of sensitivity and oiliness.MethodsA questionnaire with questions regarding subjects' basic information, skin oiliness and skin sensitivity was given to each individual who participated in the study (n = 1297). To define the thresholds for OS‐type skin, receiver‐operating characteristic (ROC) curves were generated. The results of the lactic acid stinging test (LAST) and noninvasive instrument information obtained were compared with the thresholds mentioned above to verify the effectiveness of this tool.ResultsAccording to the ROC curves, questionnaire cut‐off values of 11.5, 20.5 and 29.5 can be used to detect mildly, moderately and severely sensitive skin, respectively. In addition, the questionnaire cut‐off values of 22.5 and 31.5 can be used to detect moderately and severely oily skin, respectively. According to our study, the four sensitive‐skin groups' LAST scores differed significantly from one another, while the skin sebum levels differed significantly between the three oily groups. Additionally, the EI and LAST scores were significantly correlated with skin sensitivity levels, whereas sebum, moisture and EI were positively correlated with skin oiliness levels.ConclusionsWe developed an OS‐type skin evaluation questionnaire that has been tested and shown scientifically to be a promising method for evaluating OS‐type skin and to completely examine the traits of sensitive and oily skin.
Evaluation of diabetic foot care knowledge, determinants of self‐care practices and the efficacy of health education
Authors: Xu Xiaomei , Zheng Sensen , Cao Zhenhao , Jiang Housen , Shi Lin , Wang Zhenjie , Xu Hui 
Published: February 2024

AbstractTo evaluate the risk factors connected with diabetic foot care and investigate the impact of health education on promoting proper diabetic foot care practices. An explanatory and mixed‐method study was performed. We administered a structured pretest questionnaire to patients diagnosed with Type 2 diabetes who frequented our health examination center and community health clinics. The survey encompassed patient demographics, basic knowledge concerning diabetic foot care, and self‐care practices pertaining to diabetic foot care. Concurrent assessments and scoring were carried out. Following the survey, patients underwent health education sessions focusing on foot self‐care behaviours. Their progress was reevaluated after 2 weeks to gauge its effectiveness. We identified educational attainment, diabetes duration, regular follow‐up, and blood sugar control as critical factors influencing knowledge about foot care and self‐care practices related to it. Pearson correlation analysis demonstrated a positive relationship between scores for diabetic foot care knowledge and scores for self‐care behaviours (r = 0.32, p < 0.001). Health education led to a significant improvement in the self‐care behaviours of diabetic patients. A variety of factors affect the occurrence of diabetic foot complications and the self‐care behaviours associated with diabetic foot care. Health education proves to be an effective means of enhancing diabetic foot care behaviours.
Is the risk of wound complications after total hip arthroplasty with suture closing the skin lower than closing the skin with staples?
Authors: Xiong Xianghua , Wu Ning , Wang Wei , Luo Xiaohai , Deng Yong , Ma Xiaolin , Yang Xiao , Wang Zhaofu , Ma Feng 
Published: February 2024

AbstractThis is a study assessing the effectiveness of staples versus sutures for closing incisions after total hip arthroplasty (THA). We searched all relevant literature up to July 2023, and after reading through the full text, we finally included 5 for analysis, with a total of 1084 cases who underwent total hip arthroplasty, of which 548 were closed with staples and 536 with sutures, and evaluated the risk of bias with the Cochrane Risk of Bias Assessment Tool, using the ratio of ratios (OR) and 95% confidence intervals (CI) to compare the effectiveness of staples and sutures in wound closure in total hip arthroplasty. The study found that the suture group was superior to the staple group in terms of superficial infection and incisional exudate; superficial infection (OR = 3.04, 95% CI: 1.14–8.07; p = 0.03, I2 = 0%), incisional exudate (OR = 3.22, 95% CI: 1.84–5.65; p < 0.001, I2 = 0%) and suture staples were superior to suture group in terms of closure time (WMD = −231.8 95% CI: −429.55 to −34.05; p = 0.02, I2 = 100%). There was no remarkable distinction between the two groups in terms of deep infection, postoperative hospital, HWES score and patient's satisfaction, deep infection (OR = 1.24, 95% CI: 0.35–4.35; p = 0.74, I2 = 0%), postoperative hospital (WMD = 2.50 95% CI: −2.25 to 7.25; p = 0.30, I2 = 100%), HWES score (WMD = −0.38 95% CI: −0.52 to −0.24; p < 0.01, I2 = 72%) and patient's satisfaction (WMD = −0.23 95% CI: −1.43 to 0.96; p = 0.70, I2 = 94%); however, due to the small sample sizes of several studies included in this study, caution must be exercised when addressing their value.
Evaluating the effectiveness of proactive perioperative nursing strategies on the prevention of surgical site infections and the enhancement of skin healing in paediatric abdominal surgery
Authors: Yao Xiufeng , Xi Hongwei , Duan Wenqiang 
Published: February 2024

AbstractThe present study aimed to investigate the comparative efficacy of proactive perioperative nursing interventions versus conventional perioperative nursing care in improving wound healing, reducing the incidence of surgical site infections (SSIs) and enhancing patient satisfaction among paediatric patients undergoing elective open abdominal surgery. A total of 100 paediatric patients were enrolled in a randomised controlled trial at our hospital between January 2021 and December 2022. Inclusion criteria were patients aged <18 years who met the requirements for surgical intervention and had no contraindications to surgery or anaesthesia. Patients were randomly assigned to either an observation group receiving proactive perioperative nursing care, or a control group subjected to conventional care. Primary outcome measures included surgical incision healing grades (A, B, C), infection rates confirmed by bacterial culture within 30 days post‐surgery, patient satisfaction scores and length of hospital stay. Comprehensive statistical analyses were performed using IBM's SPSS software (version 27.0). Both groups demonstrated statistically similar baseline demographics and surgical parameters. However, the observation group showed significant improvement in wound healing outcomes (Grade A) and decreased incidence of complications (Grade C) and infections compared to the control group (P < 0.05). Patient satisfaction was significantly higher in the observation group, with 80% of patients reporting satisfaction as opposed to 20% in the control group (p < 0.05). The distribution of pathogenic bacteria in SSIs predominantly included Escherichia coli (E. coli), Pseudomonas aeruginosa, Enterococcus spp., Staphylococcus aureus and Klebsiella pneumoniae. Proactive perioperative nursing interventions demonstrate considerable benefits in improving wound healing, reducing surgical site infection rates and enhancing patient satisfaction in elective open abdominal surgery settings. However, these results require validation through large‐scale trials.
Effects of Rock Covering on Underlying Engineered Media in Bioretention Practices in Middle Tennessee, USA
Authors: Curry Blue , Ludwig Andrea , Essington Michael 
Published: February 2024

AbstractBioretention practices have become a common way to protect natural waterways in urban and suburban landscapes across the United States. However, optimal design, implementation, operation, and maintenance are still in need of study. A field survey of 52 bioretention practices was conducted in Davidson County, Tennessee, to address research questions related to operation and maintenance. A suite of site conditions were documented, such as size, signs of erosion, and dominant surface cover. Samples were collected from the surface of the engineered media layer and analyzed for organic matter content and bulk density. Vegetation was described in terms of dominant species and canopy cover. On average, the organic matter content of media under plant‐based mulch cover was significantly greater than that under rock cover (p = 0.002). Bulk density of the surface media is strongly and inversely correlated to organic matter content; bulk density did not generally vary with bioretention area age and was highly variable within treatments. On average, the bulk density of the media under the plant‐based mulch cover was significantly less than that under the rock cover. Media under the composite treatments had similar bulk density to both the plant‐based mulch (p = 0.233) and the rock covers (p = 0.132). Plant canopy did not surpass 70% in practices with bulk density values above 1.55 g/cm3. These results suggest that consideration should be made regarding the tradeoffs between utilizing rock coverings and potential for plant establishment impacts.
Evaluation of maternal serum thiol and ischemia‐modified albumin levels in cases of placenta previa: A case–control study in a tertiary center
Authors: Denizli Ramazan , Tanacan Atakan , Bastemur Ayşe Gülçin , Sakcak Bedri , Farisogullari Nihat , Kara Özgür , Kutman Hayriye Gözde Kanmaz , Neselioglu Salim , Erel Özcan , Sahin Dilek 
Published: February 2024

AbstractAimWe aim to compare the maternal serum thiol and ischemia‐modified albumin (IMA) levels between pregnant women with placenta previa and those with uncomplicated pregnancies and to determine whether changes in these levels were useful in predicting cases of abnormally invasive placenta (AIP).MethodsFifty‐five pregnant women diagnosed with placenta previa according to the diagnostic criteria (case group) were compared to 100 women with uncomplicated pregnancies of similar demographic characteristics (control group). The patients with placenta previa were further divided into two subgroups: AIP (n = 20) and placenta previa without invasion (n = 35). The maternal serum native thiol, total thiol, disulfide, and IMA levels of the groups were evaluated.ResultsThe native thiol, total thiol, and IMA values were significantly lower in the case group than in the control group (p < 0.001). The disulfide values were similar between the study and control groups (p = 0.488). When the AIP and placenta previa without invasion groups were compared, the levels of native thiol, total thiol, disulfide, and IMA were similar (p > 0.05).ConclusionsMaternal serum thiol and IMA levels were lower in placenta previa cases compared to the control group. However, these parameters were not useful in predicting AIP cases.
Chronic viral hepatitis C micro‐elimination program using telemedicine in Guigang city
Authors: Lv Riying , Lu Yanmeng , Xiang Wenyao , Meng Menglan , Li Shixiong 
Published: February 2024

AbstractHepatitis C virus (HCV) represents a formidable menace to human health, necessitating urgent attention. The objective of this study was to assess the efficacy and safety of HCV health management in the city of Guigang which consists of five districts, employing a comprehensive multi‐modal approach. The study systematically carried out HCV screening in Guigang city which consists of five districts, such as Gangbei District, Gangnan District, Guiping District, Qintang District, and Pingnan District from 1 January 2016 to 30 December 2022. The target population consisted of individuals residing in these aforementioned districts, falling within the age range of 30–75 years. A multidisciplinary HCV management team was established to deliver anti‐HCV screening, diagnosis, and direct‐acting antiviral (DAA) therapy. The primary outcome of interest was the achievement of sustained virologic response (SVR). A total of 2489 individuals were included as the target population, with 1694 individuals residing in Gangbei District, 202 in Gangnan District, 111 in Qintang District, 167 in Pingnan District, and 315 in Guiping District. Out of these individuals, 2478 were subjected to anti‐HCV screening. The screening rates varied across the districts, ranging from a peak of 99.55% in Guigang City to a nadir of 98.41% in Guiping District. Remarkably, within Guigang City, a noteworthy enhancement was observed in the HCV‐RNA diagnosis rate from 23.4% prior to program implementation to a remarkable 100% following 7 years of intervention and management. Furthermore, the diagnosis and treatment coordination rate experienced a substantial improvement, rising from 26.8% before program inception to 80%. Importantly, a total of 1180 individuals affected by hepatitis C were successfully cured, equating to a 100% cure rate. Logistic regression analysis revealed a significant association between serological status and factors such as Aging, bilirubin, and glutamic oxalacetic transaminase. The findings from our investigation unveil a pioneering HCV management model, exemplified by the Guigang model, which has contributed crucially to HCV microclearance efforts and serves as an invaluable reference for future initiatives.
Institutional factors influencing productivity in medieval England: A case study of tin, lead and silver mining
Authors: Casson Catherine , Casson Mark 
Published: February 2024

AbstractThis paper fills a gap in recent literature on productivity and regional development by examining the determinants of productivity in primary industries in English regions during the Middle Ages. It provides a comprehensive review of relevant literature on the tin, lead and silver mining industries in Medieval England. Modern studies of productivity typically focus on technology, labour skills, unionization and regional economic infrastructure as key determinants of productivity growth and focus on high‐technology manufacturing industries This study of medieval mining, however, focuses on extractive industries in which advanced technologies played only a limited role. The paper shows that alternative factors contributed to the productivity of medieval mining including royal policy, the location of deposits and fluctuations in demand. Technology, investment in training and worker activism had, in contrast, little impact.
Applying an intersectional understanding of extra work behavior and emotional exhaustion in local public service
Authors: An Brian Y. , Barboza‐Wilkes Cynthia J. , Resh William G. 
Published: February 2024

AbstractIn recent years, public administration scholars have started paying attention to intersectionality of government workforce identities and its implications for diversity management. This study unpacks how the intersection of multiple identities increases the transaction costs inherent to underrepresentation by looking at employee engagement in uncompensated extra‐role behaviors and its effect on emotional exhaustion. Using a structural equation model, we analyze original survey data of Los Angeles city government employees. Our analysis finds that the extra work experiences of minority employees are not homogenous within racial, gender, or generational groups. Among Black employees, it is women who bear the brunt of extra work burden. Further, among Black women, it is older generations who disproportionately engage in extra work and suffer from emotional exhaustion. An intersectional approach is critical to identifying the personnel most vulnerable to disproportionate job burdens and developing the human resource management practices that better support a diverse workforce.