bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron Metabolism Dysregulation and Atherosclerotic Changes in Obstructive Sleep Apnoea
Authors: Manolov Victor , Georgiev Ognian , Vasilev Vasil , Emilova Radoslava , Petrova Iulia , Hadjidekova Savina , Angov Georgi , Kunchev Todor , Tzatchev Kamen , Traykov Latchezar , Pencheva Ventsislava 
Published: October 2023

The Syndrome of obstructive sleep apnoea (OSA) is associated with an increased risk of arterial hypertension, metabolic syndrome, diabetes mellitus type 2, brain-vascular damages and atherosclerosis.
The aim of this study is to assess the connection between iron metabolism dysregulation in OSA and atherosclerotic changes of carotid arteries.
Thirty-five OSA patients with brain-vascular atherosclerotic evidences were included in this study; changes were evaluated by carotid artery intima-media thickness (IMT) and flow-mediated dilatation (FMD). Their results were compared to an equal number of healthy volunteers. Haematological and biochemical assays were performed in all participants in the study.
Serum hepcidin levels are statistically significantly increased in OSA patients with atherosclerotic a. carotis changes (101.9±10.1 µg/L) compared to the control group (18.5±2.5 µg/L); $$P<0.001$$. Serum homocysteine levels are significantly higher in OSA than in healthy people. Average IMT (1.22±0.19) and ABI (1.71±0.14) values in OSA patients with atherosclerotic a. carotis changes are increased in comparison to the control group (0.34±0.07, 1.11±0.06, resp.); $$P<0.001$$. Serum vitamin B12 levels were lower in OSA patients with atherosclerotic changes in carotid arteries (71.7±9.9 pmol/L) compared to the controls (449.7±21.4 pmol/L); $$P<0.001$$.
A connection between iron homeostasis and atherosclerotic changes was established during this study. Increased hepcidin and homocysteine concentrations might be connected to an elevated risk of cardio- and brain-vascular diseases in OSA. The use of these markers in the routine practice may be very useful for early atherosclerosis assessment in OSA.
The efficacy of digital cognitive behavioral therapy for insomnia and depression: a systematic review and meta-analysis of randomized controlled trials
Authors: Lin Wenyao , Li Na , Yang Lili , Zhang Yuqing 
Published: October 2023

Background
Insomnia and depression often co-occur. Cognitive behavioral therapy for insomnia (CBT-I) seems to be effective and safe for mitigating insomnia and depression. However, the efficacy of digitally-delivered CBT-I (dCBT-I) remains unclear. Therefore, this meta-analysis of randomized controlled trials (RCTs) was to systematically review and evaluate the efficacy of dCBT-I in adults with insomnia and depression.

Methods
A systematic search in PubMed, Cochrane, Embase, and Web of Science databases (as of June 5, 2022) was conducted for RCTs on dCBT-I. Statistical analyses were performed using Revan Manager. The effects of dCBT-I on insomnia and depression were expressed as standardized mean difference (SMD) with 95% confidence intervals (CIs).

Results
Seven studies involving 3,597 participants were included. This meta-analysis showed that dCBT-I reduced the severity of insomnia (SMD = −0.85, 95% CI [−1.00 to −0.69], p < 0.001) and depression (SMD = −0.47, 95% CI [−0.55 to −0.38], p < 0.001) in short terms, and also mitigated the severity of insomnia (SMD = −0.71, 95% CI [−1.00 to −0.44], p < 0.001) and depression (SMD = −0.42, 95% CI [−0.68 to −0.15], p = 0.002) in long terms. The effect of dCBT-I was comparable to that of traditional face-to-face CBT-I, and was generally maintained at follow-ups of 6 weeks to 6 months.

Conclusion
dCBT-I seems to be effective in alleviating insomnia and depression and might be considered as a viable treatment option for depression.
Solids Reduction Process for Agricultural Effluent – A Laboratory Feasibility Study
Authors: Dölle Klaus , Röhlen Philip 
Published: October 2023

Process steps of flocculation, filtration and centrifugation are investigated to better utilizing existing storage capacity of agriculturally based effluents and at the same time minimize the environmental impact of agricultural operations.
As flocculant Ca(OH)2 as a 20% solution, FeCl3 as a 30% solution, and Al2(SO4)3 as a 20% solution were used.
The solids content of the liquid manure, having a preadjusted pH of 9.5, resulted in a solids reduction of up to 46.8% with centrifugation.
For all flocculants, the 20% Ca(OH)2 solution, the 30% FeCl3 solution, and the 20% Al2(SO4)3 solution resulted in a decrease of the solids content of the liquid manure.
FeCl3 as flocculant reduced the solids content by 45%, Al2(SO4)3 and Ca(OH)2 as flocculant by 21.0% after the second centrifugation process. Filtration as the fourth process step reduced the solids content further by 31.6% for the Ca(OH)2 flocculant, whereas for FeCl3 and Al2(SO4)3 as flocculant and increase of the solids content by 18.2% and 2.5% respectively resulted.
The flocculant Ca(OH)2 outperformed FeCl3 and Al2(SO4)3 by 71.2%, 65.4%, and 56.9% respectively.
A Maximum COD removal rate of 47/8% could be realized without flocculant and 70.6% COD removal rate could be utilized using FeCl3 as flocculant applying a second centrifugation process.
The Role of ICT in Effective Dissemination of Extension Information among Women Livestock Farmers in North West Region of Cameroon
Authors: Forbang Loveline Enjoh , James Kinsam 
Published: October 2023

Over the past years, extensive efforts have been made throughout the world to provide female farmers with effective, suitable technology, training, and information. As a result, positive effects are beginning to show in agricultural production and family welfare. But the successes are limited at a time when public sector investments in agricultural research and extension are under pressure, when ever-greater demands are being placed on rural women in the face of rapid social transformation and in an increasing number of areas, when evidence of environmental degradation is growing. ICTs are now being used to provide basic solutions to farmers and are increasingly being supported by extension practitioners for use in agricultural production and marketing systems. This paper is intended to investigate the role played by ICT in the dissemination of effective extension information among women livestock farmers in the North West Region of Cameroon. Primary data were collected through the use of structured questionnaires, observations, focus groups and interview guides. Secondary data were obtained from books, journals, research projects and scientific articles. These provided the necessary quantitative and qualitative data that were used to draw conclusions. Multi stage sampling techniques were used to select the female farmers for the study. Four hundred (400) questionnaires were administered randomly to collect data from the communities. The women were examined using different channels like media, phone calls, friends, and agricultural technicians. The results from the study shows that, the media seemingly are doing a great job in disseminating of appropriate agricultural information. Therefore, 40.5% of the farmers get information from the media or magazines but only (7.8%) get information through phone calls. The findings of this study can go a long way to help policy makers in planning and designing need-based information infrastructural system for rural farmers.
Factors Predisposing to Postdural Puncture Headache after Spinal Anaesthesia among Elective Caesarean Section Patients at Thika Level 5 Hospital, Kenya
Authors: Nduku Munavu Angelina , Jackson Onyuka , Wambui Mwangi 
Published: October 2023

Background: Postdural puncture headache (PDPH) is a common complication following spinal anaesthesia for Caesarean section (CS). There is little data on the incidence and its predisposing factors in low-income countries. The study aimed to investigate the incidence and factors predisposing patients to PDPH after a dural puncture during a planned Caesarean section under spinal anaesthesia at Thika Level 5 Hospital, Kenya.
Methods: A cross-sectional study design was used. Pregnant women scheduled for planned Caesarean sections under spinal anaesthesia at Thika Level 5 Hospital were randomly recruited. Data was collected during the fourth quarter of 2021. Patient factors (age, BMI, bed rest, and previous history of PDPH), healthcare provider factors (qualification, experience, and the number of dural punctures), and equipment factors (size, design, and spinal needle orientation) were evaluated to determine predisposing factors for PDPH. Sample size obtained by the use of Fisher’s formula, resulting in a sample size of 103.
Results: We found the incidence of PDPH at Thika Level 5 Hospital to be 24.5%. Patient and equipment factors were found to be associated with PDPH. Among the patient factors, high BMI was found to be significant (p = 0.039) while among the equipment factors, traumatic needle tip design (p = 0.049) and the perpendicular orientation of needle bevel (p = 0.022) were found to be associated with PDPH.
Conclusion and Recommendations: We conclude that PDPH is a common complication following spinal anaesthesia for Caesarean section, and the incidence (24.5%) is relatively high at Thika Level 5 Hospital. High BMI, traumatic cutting spinal needle tip design and perpendicular orientation of the needle bevel are predisposing factors. Further research is needed to determine the predisposing factors of PDPH at different levels of hospitals in Kiambu County, and understand the specific mechanisms and measures to minimize the incidence PDPH
Influence of Social Factors on Utilization of Antenatal Care Services: A Case in Njombe Town Council for the Three Health Facilities; Njombe Urban, Idundilanga and ARCS Health Center
Authors: Masanje Augustino Francis , Msomba Given , Ruheza Sosthenes 
Published: October 2023

The focus of this study was to assess the influence of social factors on utilization of Antenatal Care services in Njombe Town Council. This study was of quantitative whereas, cross section research design was used to capture data at one time. Questionnaire was used to collect data for statistical analysis from pregnant women who acquire and attain ANC services, as three health facilities supported for the collection of qualitative and quantitative data. Questionnaire was found to be suitable as it captured measurable data which were suitable for hypothesis testing. The researcher employed Simple random sampling, as it was used to draw out 182 respondents from the targeted population in the context of Njombe Town Council.
Using chi square analysis and mean score analysis, findings revealed that social factors had significant influence on the utilization of ANC services for pregnant women in Njombe Town Council. It was further found out that, husband communication with pregnant women was highly contributing to their partners to effectively utilize ANC services when compared with the communication by pregnant women with the health workers and relatives. Also, it was found out that pregnant women with secondary level of education were utilizing more ANC services when compared with pregnant women with other levels of education. Based on these findings this study concludes that social factors was significant influencing utilization of ANC services. This study recommends that professional training to the health cares for providing health care on ANC services to pregnant women to regularly access ANC services, should be implemented by the government in order to sufficiently improve provision of ANC services hence reduce potential risks for the mother and child throughout the maternity period.
Effect of Organic Manures and Biofertilizers on Herb Yield and Economics of Kalmegh (Andrographis panniculata Wall. Ex. Nees. ) var. CIM Megha
Authors: Amala D. , Kumar M. Raj , Kumar A. Kiran , Kumar B. Naveen , Gouthami P. , Sathish G. 
Published: October 2023

Aim: To study the effect of organic manures and biofertilizers on growth, herb yield and economics of kalmegh.
Study Design: The experiment was carried out with 13 treatments in Randomized Block Design (RBD) with three replications.
Place and Duration of Study: The research trial was carried out at P.G students research block, College of Horticulture, Rajendranagar, SKLTSHU, Hyderabad during Kharif, 2021.
Results: Among the organic and biofertilizer treatments combinations the results reported that the (T6): 75 % N through VC + 12.5 % N through NC + 12.5 % N through PM + AMC recorded the highest herb yield and Benefit cost ratio compared to other treatments.
Conclusion: Organic produce fetches higher price in market compared to inorganic produce, which helped in increasing the gross returns, net returns and highest B:C ratio.
Performance of Cotton (Gossipium hirsutum L.) Varieties under High Density Planting System in Alfisols of Telangana, India
Authors: Reddy K. Indudhar , Ramanjaneyulu A. V. , Geetha A. , Seshu G. , Reddy D. Vishnuvardhan 
Published: October 2023

Aims: Cotton productivity is lower in India than the global average due to inadequate soil moisture during boll formation stage due to cessation of south west monsoon. Cotton is mainly grown under rainfed conditions in marginal and shallow soils, cultivating short duration cotton varieties with high density could improve productivity in the rainfed regions. So, this experiment was conducted to evaluate the three cotton varieties and a hybrid under four high density spacings.
Study Design: The experiment was laid out in split plot design and replicated thrice.
Place and Duration of Study: The field experiment was conducted for three years during Kharif 2014, 2015 and 2016 at Regional Agricultural Research Station, Palem, Nagarkurnool District of Telangana state, India. The experimental site was located at 16.51703° North latitude and 78.2469° East longitude and an altitude of 478 m above mean sea level.
Methodology: Treatments consisted of 4 spacings (45×10 cm, 60×10 cm, 75×10 cm and 90×10 cm) under main plots and 3 non bt cotton varieties (Suraj, WGCV-48 and ADB-39) and 1 Bt Cotton hybrid Jadoo was included as 4th treatment under subplots during 2015 and 2016. The soil at the site was Alfisol with low organic carbon (0.24%) and N (210 kg ha-1), high in available P (75 kg P2O5 ha-1) and available K (455 kg K2O ha-1). The crop was cultivated under rainfed conditions. Intercultivation and hand weeding was done and kept weed free. Gross plot size of 9 m × 3 m was maintained for each treatment. Nitrogen dose of 40 kg N ha-1, 20 kg P2O5 ha-1 and 20 kg K2O ha-1 was applied. The single plant data was collected on five tagged plants in each plot of each treatment and yield data was collected from the net plot area.
Results: Seed cotton yield was significantly influenced by the spacing and the varieties. The pooled data of 3 years revealed that cotton crop under 90×10 cm spacing (2054 kg ha-1) recorded significantly higher seed cotton yield than the crop under 75×10 cm (1854 kg ha-1), 60×10 cm (1723 kg ha-1) and 45×10 cm (1603 kg ha-1). The pooled data of 3 years revealed that the seed cotton yield in hybrid Jadoo (2189 kg ha-1) was significantly higher than the three varieties. The seed cotton yield in all the three varieties (Suraj, WGCV-48 and ADB-39) was on par with each other during all the years under study.
Conclusion: High density spacing of 90×10 cm, recorded significantly higher seed cotton yield than the other tested spacing. Among the varieties and the hybrid, cotton Jadoo outperformed all the cotton varieties and seed cotton yield of cotton varieties (Suraj, WGCV-48 and ADB-39) was on par with each other.
Incidence and Factors Associated With Recurrent Pericarditis in Lupus
Authors: Kim Yoo Jin , Lovell Jana , Diab Alaa , Magder Laurence S. , Goldman Daniel , Petri Michelle , Fava Andrea , Adamo Luigi 
Published: February 2025

ImportancePericarditis is the most common cardiac manifestation of systemic lupus erythematosus (SLE) and is known to recur among patients. However, the prevalence of and risk factors associated with recurrent pericarditis in patients with SLE were unknown.ObjectiveTo investigate the frequency of and risk factors associated with the recurrence of pericarditis in patients with SLE.Design, Setting, and ParticipantsThis cohort study was a retrospective analysis of a well-characterized, single-center prospective cohort of a diverse group patients with SLE treated at a tertiary medical center and enrolled between 1988 and 2023. Patients diagnosed with pericarditis among those enrolled in the Hopkins Lupus Cohort were included. Data were analyzed from April 2023 and May 2024.Main Outcomes and MeasuresRecurrence of pericarditis was assessed. The Safety of Estrogens in Systemic Lupus Erythematosus National Assessment revision of the SLE Disease Activity Index (SELENA-SLEDAI) was used to define pericarditis. Clinical information was examined for all follow-up encounters after the first episode of pericarditis. Episodes that occurred at least 6 weeks after the first recorded episode were defined as recurrent.ResultsOf 2931 patients within the Hopkins Lupus Cohort, 590 patients had a history of pericarditis (257 patients aged &amp;lt;30 years at first episode [43.6%]; 535 women [90.5%]; 303 Black [51.4%] and 253 White [42.9%]). In 21 patients (3.6), the diagnosis of pericarditis was confirmed via electrocardiogram or dedicated imaging, with 100% concordance between clinical and database diagnoses. During a median (IQR) follow-up of 6.7 (2.5-13.6) years and a total of 5277 years of follow-up, 120 patients (20.3%) experienced recurrent pericarditis (recurrence rate = 0.053 recurrences; 95% CI, 0.047-0.059 recurrences per person-year of follow-up). Among patients with recurrence, most patients (61 individuals [50.8%]) experienced only 1 recurrence, whereas 59 patients (49.2%) had 2 or more recurrences. In multivariable analysis, factors associated with recurrence included younger age (≥60 vs &amp;lt;40 years: rate ratio [RR], 0.11; 95% CI, 0.04-0.32), treatment with prednisone (≥20 mg vs 0 mg: RR, 1.99; 95% CI, 1.17-3.40), active SLE disease (SLEDAI ≥3 vs 0: RR, 1.55; 95% CI, 1.21-2.00), and time since initial episode (3-10 years vs &amp;lt;1 year: RR, 0.32; 95% CI, 0.20-0.52).Conclusions and RelevanceIn this study, recurrence was more likely within 1 year of the onset of pericarditis and among younger patients, those with uncontrolled disease, and those receiving oral prednisone therapy, with a dose-dependent association. These findings may set the basis for future studies to define optimal treatment for recurrent pericarditis in patients with SLE and suggest that oral corticosteroids should be avoided when treating pericarditis in patients with SLE.
Pioneering the Future: Principles, Advances, and Challenges in Organic Electrodes for Aqueous Ammonium‐Ion Batteries
Authors: Shi Mangmang , Zhang Xiaoyan 
Published: February 2025

AbstractAqueous ammonium‐ion (NH4+) batteries (AAIBs) have recently been considered as attractive alternatives for next‐generation large‐scale energy storage systems, on account of their cost‐effectiveness, nonflammability, less corrosive, small hydrated ionic radius, and rapid NH4+ diffusion kinetics. In addition, the tetrahedral structure of NH4+ exhibits preferential orientation characteristics, resulting in a different electrochemical storage mechanism from spherical charge carriers such as Li+, Na+, and K+. Therefore, unlocking the NH4+‐ion storage mechanisms in host electrode materials is pivotal to advancing the design of high‐performance AAIBs. Organic materials, with their customizable, flexible, and stable molecular structures, along with their ease of recycling and disposal, offer tremendous potential. However, the development of cutting‐edge organic electrode materials specifically for ammonium‐ion storage in AAIBs remains an exciting, yet largely untapped, frontier. This review systematically explores the interaction mechanisms between NH4+ ions and organic electrode materials, such as electrostatic interactions including hydrogen bonding. It also highlights the application of diverse organic electrode materials, such as small molecules, conducting polymers, covalent organic frameworks (COFs), and organic‐inorganic hybrids in AAIBs. Lastly, the review addresses the key challenges and future perspectives of organic‐material‐based AAIBs, aiming to push the boundaries of cutting‐edge aqueous energy storage systems.
Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies
Authors: Zhou Shoubing , Hong Mengyu , Zhao Dan , Li Wenyu , Yuan Xiaolong , Wang Yinghong , Li Hualong , Yang Yang , Jin Tengchuan , Pan Jing 
Published: February 2025

AbstractReprogramming the tumor immune microenvironment (TIM) plays an important role in promoting the reversal of immune “cold” tumors into “hot” inflammatory tumors. Improving drug targeting, blocking immune checkpoints, and promoting the activation of immune cells are crucial for reprogramming the TIM. Here, an intercellular adhesion molecule 1‐targeted antibody‒drug conjugate in combination with a B7‐H3‐CD3 bispecific antibody is selected for TIM reprogramming, which improved the efficacy of triple‐negative breast cancer immunotherapy. This combination therapy improves drug targeting, blocks immune checkpoint pathways, and activates effector T cells to release cytokines, leading to immunogenic cell death and the release of tumor‐associated antigens. This effect promotes the maturation of dendritic cells, infiltration and activation of cytotoxic CD8+ T cells, repolarization of M1‐type macrophages, and reduction of M2‐type macrophages, immune suppressor Tregs, and MDS cells, thereby reprogramming the TIM. In addition, this innovative strategy promotes the accumulation of immune cells at metastasis sites and significantly impedes the progression of lung metastatic lesions. Overall, this study provides novel insights for reprogramming the TIM using novel immunotherapeutic strategies that leverage the synergistic effects of antibody‐drug conjugates and bispecific antibodies.
The Apparent Change in Population Structure of Green Turtles (Chelonia mydas) at a Northern Great Barrier Reef Foraging Site Over Three Decades and an Evaluation of Potential Causes
Authors: Bell Ian P. , Freeman Alastair B. , McKenzie Len J. , Yoshida Rudi L. , Miller Jeffrey D. , Ariel Ellen , Limpus Colin J. 
Published: February 2025

ABSTRACTGreen Island lies approximately 11 km off the north Queensland coast of Australia. The associated 710‐ha reef flat supports a Chelonia mydas foraging population, which has been monitored by the Queensland Government's Threatened Species Program since 1988. Population census data for this area show a significant adult age‐class‐specific population decline for C. mydas. Preliminary evaluation indicates the decline in adult age‐classed turtles is unlikely to be caused by incidental capture, habitat degradation, pollution, change of foraging sites or climate change. Traditional take (locally or during reproductive migrations) provides a plausible explanation. A continuation of this trend may threaten the existence of C. mydas in this part of the Great Barrier Reef World Heritage Area.