bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the ethical considerations of using Chat GPT in university education
Authors: Huallpa, et. al. Jorge Jinchuña 
Published: January 2025

This study investigates the moral dilemmas that arise with incorporating Chat GPT into higher education, with a focus on the situation in Latinoamerican institutions of higher learning. The study surveyed 220 peo-ple via online questionnaire to learn more about their experiences with and motivations for using AI-powered conversational agents. An overview of the demographics of the participants was provided through descriptive statistics. This investigation of the subject at hand lays the groundwork for further research. It also reveals the hidden meanings of the observed phenomena, and it suggests possible solutions to the prob-lems that have been uncovered. This research looks at how AI systems and chatbots can supplement human knowledge and judgment, as well as their potential drawbacks. The results showed that participants thought Chat GPT integration was moderately accessible and had moderately positive social attitudes. They under-stood the value and responsibility of Chat GPT in creating individualized educational opportunities. Partici-pants stressed the necessity for explicit institutional standards regarding privacy and data security. Gender, age, sense of accessibility, social attitude, opinions, and personal experience, privacy and data security, in-stitutional guidelines, and individualized learning were also found to affect participants' reliance on AI through regression analysis. The findings shed light on how the integration of Chat GPT into Latinoameri-can higher education is complicated by factors such as individual beliefs, cultural norms, and ethical prob-lems. The busy schedules of students may be accommodated and the resources they need to succeed can be made available thanks to this adaptability. In addition, natural language processing models can offer stu-dents instantaneous help via text chat, voice, or video. To fully grasp the ethical consequences and lead the creation of responsible implementation techniques, the research proposes that additional qualitative investi-gations, longitudinal studies, and comparative research across diverse contexts is required. Closing these knowledge gaps will help move the conversational AI field forward in ways that are ethical and beneficial to the classroom.
Theoretical framework for the study of the two-way relationship between migration and subjective well-being
Authors: Németh Ádám , Göncz Borbála , Kohlbacher Josef , Lengyel György , Melegh Attila , Németh Zsolt , Reeger Ursula , Tóth Lilla 
Published: January 2025

This paper provides an overview of the relevant theoretical frameworks of well-being and migration and the links between the two concepts. The article is part of the theoretical preparatory work for the MIGWELL project. We argue that subjective well-being should be a key concept in migration research, because increasing it at the individual level is a universal human desire. From this perspective, migration – if it is truly voluntary – may be a tool to reach the desired outcome of increasing well-being. In general, micro-level approaches are more suitable for linking subjective well-being and migration. In particular, the "new economics and sociology of migration", the "network theory" and the "capabilities approach" offer the implicit or explicit possibility to do so. Regarding well-being, we apply a hybrid approach, inspired by both the OECD and the WeD concepts. Finally, in this paper we propose a research design that may be suitable (with some limitations) to capture the two-way relationship between the two concepts: the impact of subjective well-being on migration intention and the effect of migration on subjective well-being.
Айтрекинг как инструмент медицинской диагностики
Authors: Шелепин Евгений Ю. , Скуратова Ксения А. , Лехницкая Полина А. , Шелепин Константин Ю. 
Published: January 2025

Introduction. The transition to personalized, predictive and preventive medicine, high-tech healthcare and health-preserving technologies is one of the priorities of scientific and technological development in the next decade. The possibility of using eye tracking for medical diagnostics meets this priority.
Eye tracking as a tool for medical diagnostics. Using eye tracking, disease detection is based on the main types of eye movements: fixations, saccades and nystagmus. However, protocols that allow a comprehensive assessment of the patient's condition have not been fully validated. The purpose of the current review is an attempt to consider studies in the Scopus, Web of Science, and RSCI databases regarding the utilizing of eye tracking as an addition to the diseases and disorders diagnosis, and to outline possible trajectories for the development of this method in the field of medicine. The article provides examples of the use of eye tracking in dementia, mild cognitive impairment, Alzheimer's disease, schizophrenia, schizotypal and delusional disorder, mood disorder, attention deficit syndrome, the consequences of a stroke, and head injuries.
Results and discussion. Eye tracking is characterized by objectivity, brief and stress-free observation of a patient, the ability to simplify the tasks presented with high diagnostic accuracy, finding a simulated disorder, supplementing existing tests, searching for latent signs, higher sensitivity compared to some neuropsychological tests, the ability to dynamically switch between tasks. As a prospect for developing diagnostic protocols based on eye tracking, it is possible to: use existing paradigms for conducting eye tracking studies, combine new paradigms with existing neuropsychological tests and methods, inherit the basic principles of examining the patient's condition, and build data analysis models. Validation on a wider sample and clarification of the list of stimuli are necessary.
Особенности саморегуляции поведения и принятия решений студентов с разными стилями и стратегиями смыслопередачи
Authors: Суроедова Елена А. , Попов Дмитрий И. , Вертий Екатерина Ю. 
Published: January 2025

Introduction. In the modern educational space, characterized by dynamism, information saturation and multitasking, the study of the process of meaning transmission, self-regulation of behavior and decision-making by students come to the forefront in the context of their academic and professional success. The aim of our research is to study the peculiarities of self-regulation of behavior and decision-making in students with different styles and strategies of meaning- transmission in the process of solving educational and professional tasks.
Methods. The study involved 72 students, including 64 girls, 8 boys, average age 21.1 years. Natural experiment, questionnaire and survey were used as research methods. Research methods: Questionnaire "Strategies of meaning-transmission" (Suroedova, 2011); Questionnaire "Style of self-regulation of behavior" by V.I. Morosanova (Morosanova, 2004); Melbourne Decision Making Questionnaire (Kornilova, 2013).
Results. We identified the styles of meaning-transmission: neutral, emotional, declarative, philosophical. The study found that there are significant differences in self-organization of activity and decision-making styles in students with different styles and strategies of meaning-making. Students with an active strategy of meaning-transmission are distinguished by developed skills of goal setting, planning and controlling the process of activity, they tend to collect information from different sources and consider alternative ways of solving problems, choosing the most effective. Respondents with the emotional style of meaning-transmission are distinguished by a high level of development of goal- setting and activity programming, evaluation of intermediate and final results of problem-solving, they show flexibility in choosing ways and means of solving a problem situation.
Discussion. The results of our study can contribute to the development of psychological and pedagogical technologies aimed at improving the effectiveness of learning and assimilation of professional knowledge, taking into account the students' abilities to make meaning.
Существует ли связь генетических предикторов и психологических характеристик с эффективностью психотерапии?
Authors: Ермаков Павел Н. , Ковш Екатерина М. , Воярж Анастасия Е. , Максимов Алексей Ю. , Титова Инна И. 
Published: January 2025

Introduction. The scientific review presents the results of the analysis of modern literature devoted to the study of the relationship of genetic, epigenetic and psychological factors with the effectiveness of psychotherapy.
Theoretical justification. Statistical data indicate that in the Russian Federation, taking into account the socio-political transformations of recent times, the population's need for psychological and psychotherapeutic assistance is increasing every year. Despite this, it is still not included in the health insurance. This is largely influenced by the lack of sufficient evidence base confirming the effectiveness of various psychological and psychotherapeutic approaches. The creation of such a system is possible based on the fundamental biological mechanisms underlying mental processes. These include, among others, genetic and epigenetic predictors. The article discusses the basic concepts of genetics and epigenetics related to psychological characteristics and the psychotherapeutic process. Models of correlation and interaction between genes and the environment are described. The results of the analysis of scientific literature devoted to the study of the influence of the carrier of "plasticity alleles", as well as genes of neurotransmitter systems on the effectiveness of psychotherapy are presented. The factors of the social environment that have a significant impact on neurobiological development are described. The relationship of the severity of DNA methylation processes with traumatic experiences on the one hand and with the effects of psychotherapeutic assistance on the other is described. The features of the relationship of methylation profiles with the psychotherapeutic effect are described. The analysis of the relationship of genetic predictors and psychological characteristics with the use of methods of cognitive behavioral therapy, therapy of PTSD, BPD, panic disorders, depression.
Discussion. The analysis of modern scientific literature on the topic allows us to conclude that the DNA methylation index can be used as a predictor of effectiveness and an indicator of the response to psychotherapy. In the future, knowledge of the relationship between genetic predictors and psychological characteristics with the effectiveness of psychotherapy can be used to develop personalized programs aimed at providing psychological assistance.
Выбор позиций взаимодействия: Темная и Светлая триады как предикторы поведения
Authors: Маралов Владимир Г. , Кудака Марина А. , Смирнова Ольга В. 
Published: January 2025

Introduction. It is important to identify factors that influence the choice of interaction positions and behavioral strategies. The Dark Triad (Machiavellianism, narcissism, and non-clinical psychopathy) and the Light Triad (faith in humanity, humanism, and Kantianism) can act as integrated factors in choosing an interaction position. This study represents the first attempt to investigate the role of the Dark Triad and Light Triad in students’ choice of interaction positions – coercion, manipulation, non-violence, and non-interference. Methods. The sample comprised of 206 students of Cherepovets State University (range: 17–24 years, mean age: 18.4 years). Research methods: (a) Short Dark Triad by Jones and Paulhus (modified by Egorova, Sitnikova, and Parshikova), (b) the Light Triad Scale by Kaufman, Yaden, Hyde, Tsukayama, and (c) the questionnaire to identify interaction positions developed by the authors. Methods of descriptive statistics, correlation and regression analysis were used. Results. When choosing interaction positions, students prefer the positions of non-violence and non-interference rather than positions of coercion and manipulation. The Light Triad traits prevail over the Dark Triad traits. The Dark Triad is positively correlated with the positions of coercion and manipulation while the Light Triad is negatively correlated. The main role in choosing the positions of coercion and manipulation is played by psychopathy, Machiavellianism and a low level of Kantianism. The Light Triad is positively associated with the position of non-violence. The greatest influence on its choice is the belief in humanity, as long as there are no traits of non-clinical psychopathy. The position of non-interference had no positive connections with the Dark Triad and Light Triad. However, its choice can be influenced in some cases by such a trait of the Dark Triad as Machiavellianism. Discussion. The Dark Triad and Light Triad play an important role in students’ choice of interaction positions. The results obtained in this study can be used both for scientific and practical purposes to develop a non-violent position among students.
Hallmarks of Quercetin Benefits as a Functional Supplementary in the Management of Diabetes Mellitus-Related Maladies: From Basic to Clinical
Applications
Authors: Farhadi Faegheh , Sharififar Fariba , Jafari Mandana , Rahimi Vafa Baradaran , Askari Nafiseh , Askari Vahid Reza 
Published: January 2025

Abstract:
Quercetin (QE), a particular flavonoid, is well known for its medicinal effects, including anti-oxidant,
hypoglycemic, and anti-inflammatory effects. In this review, the findings of QE effects on diabetes STZinduced,
alloxan-induced, and its complications have been summarized with a particular focus on in vitro, in vivo,
and clinical trials. Consequently, QE mediates several mechanisms, including ameliorating tumor necrosis
factor (TNF)-α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin (IL)-1β,
IL-8, and IL-10 expression, increasing insulin glucose uptake to inhibit insulin resistance. Moreover, QE stimulates
insulin secretion and attenuates insulin resistance through various pathways, namely transient KATP channel,
motivating peroxisome proliferator-activated receptor expression, increasing glucose transporter-4, and decreasing
inducible nitric oxide synthase in skeletal muscle. QE has protective effects on the complications
caused by diabetes, such as polycystic ovary syndrome, high-fat diet-induced obesity, diabetic-induced hepatic
damage, vascular inflammation, nephropathy, and neuropathy.
Precision Medicine in Colorectal Cancer: Targeted Therapies and Biomarker Insights
Authors: Srivastava Shriyansh , Anand Amit , Kandhula Anil Goud , Jaiswal Pooja , Kumar Sachin , Gulati Monica , Sachdeva Monika , Behl Tapan 
Published: January 2025

Abstract:
The current review delves into the transformative role of precision medicine in addressing Colorectal Cancer [CRC], a pressing global health challenge. It examines closely signalling pathways, genetic and epigenetic modifications, and microsatellite in-stability. The primary focus is on elucidating biomarkers revolutionizing CRC diagnosis and treatment. Genetic biomarkers encompass non-coding RNA, epigenetic markers, TP53 mutations, and KRAS, NRAS, and BRAF gene alterations. Targeted therapies, including anti-EGFR, anti-VEGF, immune checkpoint inhibitors, and HER2-targeted treatments, are explored along with their mechanisms and clinical applications. Additionally, we highlight the importance of utilizing personalized treatment strategies by employing molecular pro-filing and genetic testing. These approaches facilitate the identification of appropriate pa-tients for targeted therapies. Clinical trials supporting these treatments are presented, em-phasizing response rates and survival outcomes. Detailed exploration of resistance mecha-nisms to targeted therapies and strategies to overcome resistance is also provided, paving the way for more effective regimens. Directions for future research in precision medicine, such as biomarkers, combinations, and liquid biopsy in the oncology field, are described. However, the precise application of precision medicine in CRC comes with questions such as costs, considerations of ethical factors, and the need to sensitize patients. Nonetheless, based on a meticulous analysis of several aspects, precision medicine finds itself equipped with the ability to enhance the patients’ prognosis ,thereby, lessening the global oncologic burden of CRC and provide important information to the clinician-scientist and policy-maker that might benefit from the ongoing development of precision medicine.
Reported Postoperative Surgical Site Infections in Tertiary Care Hospitals,
Systematic Review of Recent Literature
Authors: Nadeem Soam , Hameed Afra Abdul , Gillani Syed Wasif , Rathore Hassan Anwer 
Published: January 2025

Purpose:
The objective of this systematic review is to evaluate the patterns of postsurgical site infections, pre-surgical antibiotics prophylaxis, and related clinical outcomes in the
recently published literature.

Methods:
This systematic review is registered with PROSPERO registration number
CRD42023398963. Several databases and individual journal websites were used to collect data
from PubMed/Medline, TRIP, SCOPUS, Elsevier, Springer, ProQuest, and EMBASE. The established criteria of inclusion were RCTs, retrospective, prospective, and cross-sectional studies
with patients who had a recent surgical procedure. Excluded from the study designs were systematic reviews, prospective studies, data on pediatrics, and data on disabilities. Quality assessment analysis of the results for randomized controlled trials (RCT) used CONSORT guidelines and STROBE guidelines for cross-sectional and cohort studies.

Results:
A total of 328 articles were identified from different databases. Among them, 15 studies were included for data extraction and qualitative analysis. A total of 33,193 patients with an
average rate of 11.5% (surgical site infections- SSIs) were identified in these studies during
2008-2022. The mean rate of SSIs among the total number of immunocompromised patients/procedures was 10.2%. The SSI on patients undergoing major surgical procedures with
visible incisions was 26.0%. The majority of the studies reported the use of pre-surgical antibiotic prophylaxis. Cefazolin was mostly prescribed antibiotics and administered in 90% of patients. Other antibiotics included ceftriaxone (4%), cloxacillin (3%), and vancomycin (4%). The
mean reported rate of SSIs with combination antibiotic prophylaxis therapy was 22.8%.

Conclusion:
This systematic review concluded the limited reported data on surgical site infections (SSIs). The overuse of pre-surgical antibiotic prophylaxis has been reported in several
studies. This study recommended developing standardized guidelines on the use of antibiotics
related to surgical cases rather than co-morbidities
Tissue Plasminogen Activator for COVID-19-induced Severe Acute
Respiratory Distress Syndrome: A Controlled Clinical Trial
Authors: Naderpour Zeinab , Aliannejad Rasoul , Mehrtash Vahid , Mollazadeh Reza , Hosseini Seyedeh-Esmat , Amini Shahideh , Pak Neda , Motlaq Tahereh Madani , Khodaei Behzad , Jafarzadeh Bita , Habibi Reza , Madreseh Elham , Vasei Mohammad , Solaymani-Dodaran Masoud 
Published: January 2025

Objective:
This study aimed to assess the safety and efficacy of tissue Plasminogen Activator (tPA) in patients with COVID-19-induced severe Acute Respiratory Distress Syndrome (ARDS).

Methods:
The intervention group consisted of eligible patients with severe ARDS due to COVID-19
admitted to the Intensive Care Unit (ICU) of a university hospital. We selected the control group from
admitted patients treated in the same ICU within the same period. The intervention group received
intravenous tPA as 10 mg stat, 40 mg over the first 2 hours, and 25-50 mg over the next 10 hours,
followed by a therapeutic dose of enoxaparin. The control group only received the therapeutic dose of
enoxaparin. The main outcomes were the rise of SpO2 within 24 hours of tPA administration, critical
bleeding during tPA administration, 28-day in-hospital mortality following admission to the ICU, and
length of stay in the ICU.

Results:
We analyzed two sets of 15 patients in the intervention (mean age: 45 years, 69% male) and
the control (mean age: 50 years, 50% male) groups. There was rapid relief of dyspnea and SpO2 rising
within 24 hours in seven cases (45%) only in the intervention group with no significant organ-threatening bleeding. Death was observed in 5 of the tPA-treated patients (33.3%) versus 10 (66.7%) of the
controls [adjusted OR (95%CI): 0.17 (0.03, 0.98), P value =0.068].

Conclusion:
The administration of intravenous tPA as 10mg stat, 40 mg during 2 hours, and 50mg
during the next 10 hours is safe, can cause a rapid relief of dyspnea, and be lifesaving
Phosphodiesterase Inhibitors: A Therapeutic Approach for ArsenicInduced Neurotoxicity
Authors: Bhatt Sonia , Singh Ajay Pal , Kumar Sokindra 
Published: January 2025

Introduction:
One of the world's most serious health issues is arsenic toxicity. Prolonged consumption of Arsenic contaminated water causes cognitive damage in the developing and adult brain. The present research investigated how sodium arsenite-induced neurotoxicity in SD rats was affected by rolipram, a PDE4 inhibitor, and vinpocetine, a PDE1 inhibitor.

Methods:
The arsenic concentration was determined, which indicates the accumulation of arsenic in blood. The low weight of the brain indicates the adverse effects on the brain, which
was significantly improved by rolipram and vinpocetine. Biochemical markers (MDA, GSH,
CAT, and SOD) and protein expression of CREB and P-CREB were studied in the hippocampal region of the brain.

Results:
The reduced antioxidant activity and elevated levels of inflammation were significantly improved by rolipram and vinpocetine administration. Additionally, rolipram and
vinpocetine significantly increased the CREB and P-CREB expression in the hippocampi of
rat brains.

Conclusion:
PDE4 and PDE1 inhibition in arsenic-induced neurotoxicity could be a novel approach and a new drug therapy for arsenic-induced neurotoxicity.
La imposibilidad e ilegalidad del uso de la fuerza en Corea del Norte en el gobierno Bush (2001-2006) como opción para resolver la crisis nuclear norcoreana
Authors: Torres Rojas Gloria Milena 
Published: January 2025

La cuestión nuclear de Corea del Norte, que sigue sin resolverse desde la primera crisis nuclear, surgió en 1994. A pesar de que se han hecho esfuerzos para resolver la crisis, hasta ahora el impasse nuclear no se ha resuelto totalmente. El estudio busca demostrar que cualquier uso de la fuerza en Corea del Norte traería riesgos políticos, militares y en el derecho internacional, razones por las cuales ha sido descartada como opción para Estados Unidos.
La importancia de este estudio consiste en evidenciar que el uso de la fuerza en Corea del Norte tiene límites, dadas las implicaciones y riesgos de esta política, especialmente para Estados Unidos, Corea del Sur, Japón, China y Rusia. La metodología es de índole cualitativa porque recurre a descripciones y análisis del objeto de estudio. Este trabajo se divide en cinco partes: en la primera se discutirá la diferencia entre Preemption y Prevención. En la segunda, las implicaciones militares que cualquier eventual uso de la fuerza en la RPC tendría para los vecinos de Estados Unidos y Corea del Norte. En la tercera parte, se considerarán los riesgos políticos del uso de la fuerza En la cuarta sección se discutirán las implicaciones para el derecho internacional, y en la sección final se expondrán las conclusiones.