bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional-scale flood impacts on a small mountainous catchment in Thailand under a changing climate
Authors: Rojpratak Sawitree , Supharatid Seree 
Published: November 2023

Abstract
Extreme rainfall and flooding are common during the summer monsoon season in Thailand. In this study, we utilized Robust Empirical Quantile Mapping (RQUANT) to correct the bias in precipitation, and total runoff data obtained from the latest Couple Model Intercomparison Project phase 6 (CMIP6) for the upper Lam Takong river basin. Five different methods were employed to estimate the river discharge and four estimations based on Budyko functions. Our analysis revealed that the ‘Total runoff’ method yielded the most accurate representation of the observed discharge. Impacts of change in land use are examined in terms of compound roughness. The Multi-Model Ensemble (MME) precipitation under medium-emission (SSP2-4.5) and high-emission (SSP5-8.5) scenarios is projected to increase by 5.74 and 10.91%, respectively. Correspondingly, the discharges are expected to increase by 4.57 and 11.05% for the far-future periods. In general, the Flo-2D model satisfactorily simulated the water level in the main channel but it underestimated small inundation depth (&lt;0.5 m) across the floodplain. Comparing inundation maps among different scenarios and timelines, changes in the inundation area were relatively small (0.05%), especially when compared to changes in floodplain storage (6.85%) due to the mountainous nature of the river basin.
Investigating the Culture Around Sexual Harassment in First-Generation Universities in Southwestern Nigeria: Protocol for a Mixed Methods Study
Authors: Mapayi Boladale , Oloniniyi Ibidun , Oginni Olakunle , Harrison Abigail 
Published: November 2023

Background
The phenomenon of sexual harassment (SH) is a complex issue with multiple prongs that concerns all members of academia and raises serious challenges, particularly regarding prevention and response. SH in tertiary institutions remains a huge problem worldwide, leading to severe emotional, academic, and career difficulties, as well as undue suffering. Institutions have responded in various ways to alleviate the burden of SH with little success, especially in Nigeria. The prevalence is high but reportage is low because of the culture of silence around SH in most educational institutions. This study aims to identify factors associated with SH in tertiary institutions in Nigeria and explore factors surrounding reportage or nonreportage following the experience of SH, the institutional mechanisms to prevent and respond to SH, and the lived experience of survivors of SH.

Objective
The objective of this study was to present a study protocol that is designed to identify factors associated with the experience of SH in tertiary institutions in Nigeria, the institutional mechanisms to prevent and respond to SH, and the lived experience of survivors of SH.

Methods
A mixed (quantitative and qualitative) methods approach is used consisting of a policy review of existing antisexual harassment policies in the selected universities, a quantitative survey to determine the correlates of SH, focus group discussions to explore the perspectives of the university community concerning SH, in-depth interviews to explore the lived experiences of survivors of SH, and key informant interviews to understand the perspectives of people who provide interventions to survivors.

Results
This study was funded in July 2022 by the Consortium for Advanced Research Training in Africa, and data collection started in November 2022. The SH policies were comprehensive, with clear policy statements and definitions, and recognized a wide range of survivors and perpetrators. However, there was no clear mention of prevention and response to same-sex SH. Lived experiences showed negative psychological and social sequelae and little institutional support.

Conclusions
This is the first study that has a component investigating same-sex SH in tertiary institutions in Nigeria. This is also one of the first studies to explore the lived experiences of survivors of SH in Nigerian universities. The findings from this study suggest that periodic evaluation of SH policy implementation will improve institutional support, thus creating safe spaces for survivors and will thereby encourage reportage and support; prevention and response strategies need to be more inclusive; and more interventions should focus on strengthening prosocial skills and healthy, equitable relationships.

International Registered Report Identifier (IRRID)
DERR1-10.2196/49126
Diagnostic Accuracy of Single-Lead Electrocardiograms Using the Kardia Mobile App and the Apple Watch 4: Validation Study
Authors: Klier Kristina , Koch Lucas , Graf Lisa , Schinköthe Timo , Schmidt Annette 
Published: November 2023

Background
To date, the 12-lead electrocardiogram (ECG) is the gold standard for cardiological diagnosis in clinical settings. With the advancements in technology, a growing number of smartphone apps and gadgets for recording, visualizing, and evaluating physical performance as well as health data is available. Although this new smart technology is innovative and time- and cost-efficient, less is known about its diagnostic accuracy and reliability.

Objective
This study aimed to examine the agreement between the mobile single-lead ECG measurements of the Kardia Mobile App and the Apple Watch 4 compared to the 12-lead gold standard ECG in healthy adults under laboratory conditions. Furthermore, it assessed whether the measurement error of the devices increases with an increasing heart rate.

Methods
This study was designed as a prospective quasi-experimental 1-sample measurement, in which no randomization of the sampling was carried out. In total, ECGs at rest from 81 participants (average age 24.89, SD 8.58 years; n=58, 72% male) were recorded and statistically analyzed. Bland-Altman plots were created to graphically illustrate measurement differences. To analyze the agreement between the single-lead ECGs and the 12-lead ECG, Pearson correlation coefficient (r) and Lin concordance correlation coefficient (CCCLin) were calculated.

Results
The results showed a higher agreement for the Apple Watch (mean deviation QT: 6.85%; QT interval corrected for heart rate using Fridericia formula [QTcF]: 7.43%) than Kardia Mobile (mean deviation QT: 9.53%; QTcF: 9.78%) even if both tend to underestimate QT and QTcF intervals. For Kardia Mobile, the QT and QTcF intervals correlated significantly with the gold standard (rQT=0.857 and rQTcF=0.727; P<.001). CCCLin corresponded to an almost complete heuristic agreement for the QT interval (0.835), whereas the QTcF interval was in the range of strong agreement (0.682). Further, for the Apple Watch, Pearson correlations were highly significant and in the range of a large effect (rQT=0.793 and rQTcF=0.649; P<.001). CCCLin corresponded to a strong heuristic agreement for both the QT (0.779) and QTcF (0.615) intervals. A small negative correlation between the measurement error and increasing heart rate could be found of each the devices and the reference.

Conclusions
Smart technology seems to be a promising and reliable approach for nonclinical health monitoring. Further research is needed to broaden the evidence regarding its validity and usability in different target groups.
Development and Testing of an Electronic Diabetes Diary Integrated With a Hospital Information System for Individuals With Type 2 Diabetes Mellitus: Protocol for a Mixed Methods Study
Authors: Skaria Geena , Reshmi Bhageerathy , K M Sabu , Shetty Sahana , Lakshmi R Vani 
Published: November 2023

Background
Type 2 diabetes mellitus (T2DM) is one of the leading noncommunicable diseases that require diabetes self-management (DSM) practices. This study proposes to develop a customized mobile health (mHealth) app integrated with a hospital information system (HIS) to enable real-time, two-way transfer of information between the patient and physician. The captured information in the electronic health record will facilitate physicians to have a chronological account of the patient’s diabetes history and enable tweaking of the treatment.

Objective
The objectives of the study are (1) to develop the HIS-integrated Electronic Diabetes Diary (EDDy) per the end-user expectations at a tertiary care hospital in a south Indian state with a high prevalence of T2DM and (2) to evaluate and test adherence to EDDy in the management of T2DM.

Methods
The study will be carried out in 3 phases. Phase 1 involved in-depth interviews with primary end users to gather information regarding their expectations from the hospital-based EDDy. Phase 2 will use this information to develop a customized mHealth app using an iterative model of software development. Phase 3 will involve a pre- and posttest design; the developed app will be tested among consenting patients, where physicians will receive the patients’ data through the HIS-integrated mHealth app. The pre- and posttest values will be analyzed for adherence leading to improvement in patients’ self-management of blood glucose, user experience, glycemic control, and clinical utility.

Results
Phase 1 was completed on November 28, 2023. Phase 2 commenced in December 2023 and will end in May 2025. Phase 3 will follow afterward.

Conclusions
The proposed app will include a convenient and simple alert system that enables the patient to test glucose values at self-selected intervals, provide grading options to enter diabetic-related complications, enhance patients’ knowledge of tracking and managing the complications of diabetes, and help in maintaining the visual representation of glucose values and complications. The simplicity and usability of the modules are its novelty, which may motivate the patients to keep track of their glucose values and help them attain better health outcomes.

Trial Registration
Clinical Trial Registry India CTRI/2023/03/051077; http://tinyurl.com/4tau4ndb

International Registered Report Identifier (IRRID)
PRR1-10.2196/50732
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ‘KARIRA’-A VALUABLE AYURVEDIC PLANT
Authors: VERMA PREETI , PARMAR DHARMISHTHA , SUHAGIA BHANUBHAI 
Published: November 2023

Objective: ‘Karira’ is a common Sanskrit name of an important Ayurvedic medicinal plant, Capparis decidua Edgew. (family, Capparidaceae). It is a bushy shrub or small tree distributed throughout the dry areas of India and other parts of the world. As per traditional literature, various parts of the plant are widely used in the treatment of biliousness, jaundice, andas a liver tonic. Therefore the present study was aimed at the evaluation of hepatoprotective activity of Karira stem.
Methods: For the study, three types of extracts of C. decidua stem were prepared, viz. aqueous extract, alcoholic extract and 50% hydroalcoholic extract. The stem extracts were evaluated for their protective effects against carbon tetrachloride-induced acute hepatotoxicity in the rats in in vivo conditions.
Results: The results suggested that among all the three extracts, specifically the alcoholic extract at the dose of 300 mg/kg exhibited highest hepatoprotective activity, which was comparable to the standard drug, silymarin (50 mg/kg). The hepatoprotective effects were further confirmed by detailed antioxidant study, which revealed significant free radical scavenging activities and protection against lipid peroxidation offered by the extracts, along with preservation of the integrity of liver cells as evident from the histopathological study of the liver tissues.
Conclusion: The present investigation supports the traditional use of Karira plant in liver-related disorders.
HISTOLOGICAL SPECTRUM OF PREMALIGNANT AND PREINVASIVE MALIGNANT LESIONS IN CYTOLOGICALLY AND RADIOLOGICALLY DIAGNOSED BENIGN BREAST LESIONS-OUR EXPERIENCE IN A TERTIARY CARE HOSPITAL
Authors: MUSFIQUE JABIN , TALUKDAR LEENA , BARMAN MANOJ 
Published: November 2023

Objective: The aim of this study is to detect precancerous lesions and intraductal (in situ) malignancies in cytologically and radiologically diagnosed benign breast lesions and its prevalence in different age groups.
Methods: A total of 448 cases of breast lumps were diagnosed cytological as benign breast lesions in our cytology division from july 2022 to june 2023. Of these, 148 cases were available for histopathological examination.
Results: On Histopathology, 122 cases (82.4%) were diagnosed as benign lesions. 19 (12.8%) cases were found to harbour pre-malignant lesions, 06 (4.0%) cases as in-situ carcinomas and 1 (0.6%) case of encapsulated papillary carcinoma without invasion.
Conclusion: To conclude, prevention of development of carcinoma of breast is the key step to reduce the burden of morbidity and mortality. Recognising pre-malignant lesions can go a long way in reducing development of invasive carcinoma, for which histopathological examination is the most helpful tool. Thus any benign breast lesions that have been detected to harbour pre-malignant changes must be placed into a separate group than from purely benign breast lesions. These groups must be followed up and treated according to standard available protocols.
ANTICONVULSANT EFFECT OFBERBERIS ARISTATA ROOT EXTRACT IN MICE
Authors: GOEL DIVYA 
Published: November 2023

Objective: Berberine is an isoquinolone alkaloid present in many plants and reported to possess anti-diabetic, hypolipidemic, anti-cancer, anti-bacterial, anti-pyretic, antiviral and anti-inflammatory effects. In addition, berberine can modulate neurotransmitter like N-methyl-D-aspartate (NMDA), serotonin and Nitric Oxide, thus can produce anticonvulsant effect.
Methods: The seizures were induced in mice by maximal pentylenetetrazol and electroshock. The effect of root extract on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam.
Results: Theroot extract of berberine aristata suppressed duration of tonic convulsions in maximal electroshock-induced seizures while it delayed time of onset of seizure as well as significantly decreased the duration of myoclonic-jerks-in pentylenetetrazol-induced seizures. Further, the study also indicated that the root extract of berberine aristata also produced motor impairment at the antiseizure doses.
Conclusion: The present study indicated that berberine exhibits anticonvulsant activity in both models and can be useful in epileptic patients.
EPIDEMIOLOGY OF HYPERTENSIVE DISORDERS OF PREGNANCY IN INDIA
Authors: SNEHA SHRUTI , RIGVEDA RICHA , SHARMA NALNEESH 
Published: November 2023

Objective: Hypertensive disorders of pregnancy (HDP), including gestational hypertension, preeclampsia, and eclampsia, are a global concern due to their impact on maternal and fetal health. The epidemiological landscape of HDP in India, a diverse and populous nation, presents unique challenges influenced by healthcare disparities and cultural factors.
Methods: This cross-sectional study, conducted from Jul 1, 2018, to Jun 30, 2019, aimed to compare the spot urinary protein/creatinine ratio with the conventional 24 h urine protein collection method for proteinuria estimation in preeclamptic pregnant women. Ninety inpatients were included, adhering to specific inclusion and exclusion criteria. Data on demographics, blood pressure, liver function, and 24 h urine protein excretion were collected and analyzed statistically.
Results: The mean age of pregnant women with preeclampsia in India was 28.9 y (range: 18-33), with 45.55% primigravida and 65.55% multigravida. Diastolic blood pressure at admission was 94.98 mmHg±8.54, displaying variations compared to other studies, potentially influenced by genetic, dietary, and healthcare factors. Liver function test results indicated abnormal findings in 90% of cases for total bilirubin, 60% for alanine transaminase (ALT), and 60% for aspartate transaminase (AST), highlighting disparities in liver function when compared to prior research. Proteinuria levels demonstrated substantial variation, with the present study reporting a mean 24 h urine protein excretion of 1884 mg/d±2562, reflecting the complexity of proteinuria assessment across different populations and methodologies.
Conclusion: The epidemiology of HDP in India is intricate and multifactorial, influenced by diverse demographic factors, blood pressure levels, liver function, and proteinuria. Findings underscore the need for region-specific research and tailored healthcare interventions. Further investigations are essential to unravel the contributing factors to HDP in India and guide effective preventive measures and management strategies in this populous and diverse nation.
A SENSITIVE AND A SIMPLE RP-HPLC METHOD DEVELOPMENT AND VERIFICATION FOR THE QUANTITATIVE ESTIMATION OF CHOLECALCIFEROLIN TABLETS
Authors: SUBHASHINI K. , NAIDU U. TRIVIKRAM , KUMAR A. ASHOK , VOOTURI RAJESH , KUMAR N. VENU 
Published: November 2023

Objective: To develop a sensitive, simple, accurate, precise and linear Reverse Phase High-Performance Liquid Chromatographic (RP-HPLC) method and verify for the quantitative estimation (Assay) of Cholecalciferol in tablets.
Methods: The optimized method uses a reverse phase column, Waters X-Bridge C8 (150 X 4.6 mm; 3.5μ), a mobile phase of Methanol: Acetonitrile: HPLC grade water/Milli-Q water in the proportion of 60:30:10 v/v/v, flow rate of 0.8 ml/min, injection volume of 100 µl, and detection wavelength of 265 nm using a UV/PDA detector.
Results: The developed method gave Cholecalciferol eluting at about 9 min. Cholecalciferol exhibited linearity in the range 0.058-0.466 μg/ml. The precision is exemplified by a relative standard deviation of 1.40%. Percentage of individual recovery was found to be in the range of 97.0 and 103.0 during accuracy studies.
Conclusion: A sensitive, simple, accurate, precise and linear RP-HPLC method was developed and verified for the quantitative estimation (Assay) of Cholecalciferol in tablets and hence this method can be explored for the analysis of Cholecalciferol in tablets/various dosage forms in various pharmaceutical industries.
O CAMPUS E A CIDADE: MEMÓRIAS E REFLEXÕES DO CENTRO UNIVERSITÁRIO ADVENTISTA DE SÃO PAULO NO CAPÃO REDONDO
Authors: Keppke Rosane Segantin , Oliveira Raíssa Pereira Cintra de , Doerner Cleide Duarte 
Published: November 2023

O Centro Universitário Adventista de São Paulo (Unasp), antigo Colégio Adventista Brasileiro, posteriormente Instituto Adventista de Ensino, é uma instituição de ensino centenária localizada no Distrito do Capão Redondo. Foi fundado em 1915 para ser o seminário brasileiro de preparação de pastores, missionários e funcionários, quando ainda era zona rural do extinto município de Santo Amaro. A distância dos centros urbanos era adequada para a vida acadêmica, laboral e religiosa dos jovens estudantes.
No entanto, a expansão da mancha urbana os atingiu, desconstruindo seu ideal idílico e confiscando a maior parte de suas terras para a construção de Habitação de Interesse Social. Foi uma experiência marcante e pioneira de autoconstrução coletiva com assistência técnica em São Paulo e no Brasil antes mesmo do Estatuto da Cidade.
O artigo descreve este estudo de caso pela abordagem do Unasp e, por outro lado, pelos pesquisadores e arquitetos que acompanharam o início da política contemporânea de Habitação de Interesse Social no Brasil. A discussão fundamental é se o Unasp se tornou um oásis ou uma diáspora nas “quebradas” do Capão Redondo. Concluindo, este processo ainda está inacabado, porém, atualmente, a maioria dos estudantes se constitui de não adventistas, e as crescentes práticas de extensão estão induzindo a comunidade do entorno a se apropriar cada vez mais do Unasp.
DESAIN DAN UJI COBA MEDIA PEMBELAJARAN INTERAKTIF BERBASIS NEARPOD
Authors: Wulandari Elsa Avrelia , Fatisa Yuni 
Published: November 2023

AbstractLess innovative learning media, especially on Chemistry learning, made students uninterested in the learning. This research aimed at producing Nearpod based interactive learning media on Periodic System of the Elements lesson that was valid and practical based on the result of validity test by material and media experts, and practical test by chemistry teacher and students. Research and Development (R&D) method was used in this research with 4D (Define, Design, Development, and Disseminate) development model. This research was administered at State Islamic Senior High School 1 Pekanbaru. The subjects of this research were material and media experts, teachers, and students. The object was Nearpod based interactive learning media on Periodic System of the Elements lesson. The validation result by media and material experts showed that the score was 95% with very valid criterion. The result of teacher practicality test was 95.45% with very practical criterion, and the result of student practicality test was 93.27% with very practical criterion. So that, Nearpod based interactive learning media on Periodic System of the Elements lesson could be used to support the learning.Keywords : Interactive Learning Media, Nearpod, Periodic System of the Elements
PEMANFAATAN TANAH LIAT SEBAGAI MEDIA PEMBELAJARAN MOLYMOD BERBASIS GREEN CHEMISTRY PADA MATERI GEOMETRI MOLEKUL SMK KELAS X
Authors: Darnisyah Darnisyah , Safitri Yulia , Hidayati Ira 
Published: November 2023

AbstractAbstract Science learning, especially chemistry, also has an important role in shaping the character of a person through the application of scientific properties ranging from investigating, conducting experiments, discussing and communicating experimental results in a scientific process. The Green Chemistry approach is closely related to how to overcome environmental problems. Some studies suggest that green chemistry aims to minimize and or eliminate harmful substances in a chemical process, replaced with substances that are more environmentally friendly so as to overcome environmental problems. The purpose of this study was to determine the use of clay as a green chemistry-based molymod learning medium on molecular geometry material of SMK class X. This research method is descriptive research. This research was conducted in class X TBSM B SMK Negeri 2 North Tambusai which amounted to 19 people. The types of data collection carried out in this study are test and non-test. Test techniques are measurements of learners' abilities. Non-test techniques are carried out through observation of student activities during the learning process. The results showed that the use of clay was more effective in learning molecular geometry than 2D dynamic images. Keywords: Molymod, Green Chemistry, and Molecular Geometry
Slang Words in Da'wah by Popular Preachers on Youtube
Authors: Syam Muhammad Taufiq , Tike Arifuddin , Tajibu Kamaluddin , Nurhikmah Nurhikmah 
Published: November 2023

Da'wah on Youtube is a part of the process of distributing da'wah messages through social media. The preachers use slang words in da’wah as a way to attract attention to audience, as personal identity, and to meet the standards of uses and gratification of the audience, even though they have to ignore the Qaulan ethics in da'wah. This study uses a qualitative descriptive method to describe several conditions, situations and phenomena of da'wah on Youtube. Sources of research data are documentation, online surveys and in-depth interviews related to the phenomenon of using slang words in da'wah. Based on the research results, it was found that the use of slang words in da'wah aims to attract the attention of the audience, establish the personal identity, and meet the standards of uses and gratification based on cognitive, affective, and behavioral levels of the audience. A positive reconstruction is needed to minimize the occurrence of distortions in the use of slang words and the Qaulan ethics in da’wah.