bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does industrial co-agglomeration promote green energy efficiency? Evidence from spatial panel data of 284 cities in China
Authors: Yang Chongrong , Jiang Wen 
Published: December 2023

AbstractIndustrial co-agglomeration (IC) plays a pivotal role in the development of local and adjacent green energy efficiency across 284 Chinese cities, encompassing both resource-based and non-resource-based urban centers. Based on the panel data of 284 cities in China from 2005 to 2020, this study employs spatial econometric methods to empirically assess the influence of IC and its spillover effects on green energy efficiency, employing a spatial Durbin model. Additionally, the study categorizes the 284 Chinese cities into resource-based and non-resource-based categories, utilizing spatial econometric methods to delve into the heterogeneity of their effects and spillover impacts. The key findings are as follows: (1) The average green energy efficiency across the 284 Chinese cities from 2005 to 2020 stands at 0.5834. The trend in IC indicates growth and concentration towards the central areas, increasing from 2.7396 in 2005 to 2.7658 in 2020. (2) The IC, with a coefficient of 0.0918, promotes the local green energy efficiency. (3) There are spillover effects of local IC on the green energy efficiency in adjacent areas with a coefficient of 0.2550 and an Indirect Effect of 0.4567. (4) In resource-based cities, IC positively impacts local green energy efficiency with a coefficient of 0.1056 but negatively affects green energy efficiency in adjacent areas with a coefficient of −0.1368. In non-resource-based cities, IC enhances green energy efficiency in adjacent cities with a coefficient of 0.1335. Consequently, the study offers pertinent policy recommendations aimed at improving energy efficiency in light of these findings.
Is the perceptual disfluency effect moderated by working memory capacity? Direct replication of Lehmann et al. (2016)
Authors: Weissgerber Sophia C. , Terhorst Denia Indah Permatasari , Rummer Ralf 
Published: December 2023

AbstractAccording to an aptitude-treatment interaction experiment (Lehmann et al., Metacognition and Learning,11, 89–105, 2016, N = 47, published in Metacognition and Learning), perceptually disfluent texts facilitated retention and comprehension performance (but not transfer performance) only for learners with higher working memory capacity (WMC). No effects of WMC for a fluent text were found (albeit theoretically, fluency may be more advantageous for learners with lower WMC). The findings of our (pre-registered) direct replication (supervised online sample of N = 96) show a substantial deviation from the original results: In contrast to the interaction effect (disfluency and WMC) of the primary study, we obtained null results for disfluency, WMC, and their interaction for all learning outcomes. Our replication data are not indicative of WMC as a boundary condition moderating the disfluency effect on learning. We discuss discrepancies in the results of the primary study and our direct replication regarding particular methodological and analytical decisions, questioning the robustness and generalizability of Lehman et al.’s results beyond their primary study.
Effects of reading instructions on pre-service teachers’ judgment bias when learning from texts
Authors: Knellesen Jennifer , Händel Marion , Golke Stefanie 
Published: December 2023

AbstractLearning from texts means acquiring and applying knowledge, which requires students to judge their text comprehension accurately. However, students usually overestimate their comprehension, which can be caused by a misalignment between the cues used to judge one’s comprehension and the cognitive requirements of future test questions. Therefore, reading instructions might help students to use more valid cues and hence to make more accurate judgments. In two randomized experiments, we investigated the effect of application instructions (in contrast to general and memory instructions) on judgment bias regarding memory test performance and application test performance. In Experiment 1, 131 pre-service teacher students read two texts: For the first text (pretest phase), all participants received general reading instructions. For the second text (testing phase), they received one of the three reading instructions. Main results were that the general reading instructions in the pretest phase resulted in underestimation for memory test performance and overestimation for application test performance. Results from the testing phase yielded mixed effects and, overall, no strong evidence that reading instructions, and in particular application instructions, are beneficial for debiasing judgments of comprehension. Experiment 2 (N = 164 pre-service teachers) restudied the effects with the same texts but a different study design. Results replicated the effects found in the testing phase of Experiment 1. Overall, the results indicated that reading instructions without further support are not sufficient to help students to accurately judge their comprehension and suggested that text characteristics might impact the effect of reading instructions on judgment bias.
A new insight to access carbonate reservoir quality using quality factor and velocity deviation log
Authors: Larki Ehsan , Jaffarbabaei Bijan , Soleimani Bahman , Elyasi Ayub , Saberi Fatemeh , Makarian Esmael , Shad Manaman Navid , Radwan Ahmed E. 
Published: December 2023

AbstractEstimating wave damping in carbonate rocks is complex due to their heterogeneous structure. For this reason, further research in this area is still necessary. Since the identification and evaluation of reservoir quality play an essential role in the optimal use of hydrocarbon resources, efforts are made to provide new solutions to achieve this goal by managing knowledge and accessing information from new tools such as the Vertical Seismic Profile (VSP). Seismic waves are deformed in frequency content and amplitude as they pass through the earth's layers. Part of the reduction in wavelength is related to the nature of the wave propagation and part to the geological properties, including porosity and fracture. Anisotropy and velocity model analysis, rather than the direct connection between reservoir parameters and seismic absorption coefficient, have received the majority of attention in earlier studies on the impact of reservoir parameters and fractures on changes in the quality factor. In this study, the correlation of the quality factor with parameters such as velocity deviation, fracture density, and permeability has been investigated, and an attempt has been made to define the quality factor as a tool to assess the quality of the reservoir. The statistical study using the multiple linear regression method found that fracture density is the most important parameter that follows the trend of the quality factor value. In the analysis, the quality factor showed a relatively good correlation with the permeability of the core data, so in the periods with maximum permeability, the quality factor had the lowest values. According to K-Means Clustering Analysis, 18% of the studied reservoir interval was evaluated as good quality, 33% as medium, 36% as poor, and 12% as hydrocarbon-free. This work provides insight into accessing reservoir quality using quality factor and velocity deviation logs and would be valuable for the development of reservoir quality prediction methods. Based on the study's results, it is recommended to apply this technique for modeling reservoir heterogeneity and assessing 2D and 3D seismic data to predict the reservoir quality of gas fields prior to drilling operations and reduce exploration risks.
Effects of breathing variables on modelled particle lung deposition at physical activity for children and adults
Authors: Linell Julia , Isaxon Christina , Olsson Bo , Stroh Emilie , Wollmer Per , Löndahl Jakob , Rissler Jenny 
Published: December 2023

AbstractThe respiratory tract deposited fraction (DF) is the link between exposure and health effects of airborne particles. Here, we investigate how breathing pattern alterations at increasing physical activity affect DF in different regions of the respiratory tract and compare DF between adults and children (5 and 10 years old). We performed a literature review on the alteration of tidal volume with minute ventilation at increasing physical activity and used the results to model the size resolved (0.001–10 µm) DF, primarily using the deposition models from NCRP and Yeh and Schum (1980), but also MPPD. We found a shift in the deposited size distribution with increasing physical activity—DF of ultrafine particles increased in the alveolar region and decreased in the other regions, while DF of coarser particles decreased in the alveolar region and increased in the extra-thoracic region. Children had a 10–20% higher DF of ultrafine particles in the alveolar region compared to adults. We also present parametrizations of the daily average size resolved (0.005–5 µm) DF, accounting for varying physical activity throughout the day and oral/nasal breathing. These can be applied to any size distribution to estimate deposited doses. We found that deposited mass and number doses were more than twice as high for 5-year-olds compared to adults when normalized for body weight, primarily caused by their higher weight normalized minute ventilation. This demonstrates the importance of studying children’s exposure to air pollution and not only rely on data from adults.
Associations between dust exposure and hospitalizations in a dust-prone city, Lubbock, TX, USA
Authors: Herrera-Molina Estrella , Gill Thomas E. , Ibarra-Mejia Gabriel , Jeon Soyoung , Ardon-Dryer Karin 
Published: December 2023

AbstractAlthough it is a growing area of investigation in the Global Dust Belt, only a few population-level studies have evaluated the human health associations of windblown dust in North America. We investigated whether acute, short-term dust exposures (DE), in Lubbock, Texas (a medium-sized, dust-prone city in the southern Great Plains, USA) were associated with significant increases in hospitalizations on the day of the exposure and up to 7 days afterward. We used the distributed lag non-linear models in time series analysis to describe non-linear relationship between response outcomes and the delayed effects of exposure over time. We found that increased relative risks of hospitalizations for multiple conditions were associated with the two DE approaches that occurred between 2010 and 2014. Consistent with prior studies of dust health effects in other cities in North America, we identified increased hospitalization risks in Lubbock due to neurodegenerative, atherosclerosis, renal, respiratory, asthma, mental, stroke, neoplasms, ischemia, hematologic, musculoskeletal, and associated diseases (aggregation of all causes each associated with at least 5% of hospitalizations) at various dust exposure days. Associations were modified by age, gender, day of the week, and holiday effects. As climate change increases water stresses on dryland agriculture and long periods of drought, dust exposures are likely to increase for residents of dryland cities and with it the likelihood of adverse health effects on people with preexisting conditions. Additional investigations are needed for other dust-prone population centers worldwide to document the health effects of dust exposures and investigate their causes.
CTSB Nuclear Translocation Facilitates DNA Damage and Lysosomal Stress to Promote Retinoblastoma Cell Death
Authors: Li Cairui , Sun Shuguang , Zhuang Yanmei , Luo Zhaokui , Ji Guangquan , Liu Zhong 
Published: December 2023

AbstractRetinoblastoma (RB) is a pernicious tumor originating from photoreceptor precursor cells that often endangers the lives of children. The purpose of our study was to further investigate the influence of cathepsin B (CTSB) nuclear translocation on RB cell death. Y79 cells were injected into the vitreous cavity of nude mice at a dose of 4 µL/mouse to establish an animal model of RB. Real-time quantitative polymerase chain reaction (RT–qPCR), Western blot analysis, a comet assay, a Cell Counting Kit-8 (CCK-8) assay and flow cytometry were used to measure the levels of the interrelated genes and proteins and to evaluate alterations in autophagy, apoptosis, proliferation, DNA damage and cell cycle arrest. CTSB was found to be expressed at low levels in RB animal model samples and RB cell lines. Functionally, CTSB nuclear translocation promoted DNA damage, cell cycle arrest, ferroptosis and autophagy in Y79 cells and inhibited their proliferation. Downstream mechanistic studies showed that nuclear translocation of CTSB facilitates DNA damage and cell cycle arrest in RB cells by inhibiting breast cancer 1 protein (BRCA1) expression and also activates the signal transducer and activator of transcription 3/stimulator of interferon response cGAMP interactor 1 (STAT3/STING1) pathway to induce lysosomal stress, leading to ferroptosis and autophagy in Y79 cells and alleviating RB. Nuclear translocation of CTSB facilitates DNA damage and cell cycle arrest in RB cells by inhibiting BRCA1 expression and activating the STAT3/STING1 pathway and induces lysosomal stress, which eventually leads to ferroptosis and autophagy and mitigates RB.
Natural Occurrence of Fungi and Aflatoxins Associated Sugarcane Plant and Sugarcane Juice and Their Control
Authors: Younos Marwa A. , Embaby E. M. 
Published: December 2023

AbstractSugarcane is one of the most important crops in the world. It is also considered the most popular fresh juice in Egypt. The sugar content of the sugarcane stem represents the main source of fungal growth. This study aimed to investigate the natural co-occurrence of fungi in sugarcane plants and juice, test of aflatoxins production by aflatoxigenic fungi, and improve the quality of sugarcane juice. The obtained results indicated a notable decrease in all physical parameters of the naturally infected sugarcane plants. Isolation of fungi from sugarcane plant and juice from three localities revealed that the highest mean fungal count was recorded in sugarcane rootlets (173.55 cfu/cm), followed by sugarcane stem (94.88 cfu/cm), while sugarcane juice had the least mean fungal count (24.33 cfu/mL). The frequency of the isolated fungi associated with sugarcane plant yielded 781 fungal isolates for rootlets, 427 fungal isolates for stems, and 219 fungal isolates for juice. Four isolates of Aspergillus parasiticus were aflatoxins producers. Higher aflatoxin quantity (1434.92 ng/mL) was produced by A. parasiticus (isolate No. 21) from sugarcane stem, while A. parasiticus (isolate No. 5) from sugarcane juice was less aflatoxins producer (276.95 ng/mL). On the other hand, lemon juice showed a significant reduction effect on the fungal count of peeled and non-peeled sugarcane juice. In which the highest reduction percent of the fungal count was recorded with 20% conc. of lemon on peeled sugarcane juice (36.04%).The obtained results concluded that lemon juice was found to decrease the fungal contaminants and improve the quality of sugarcane juice.
Sustainable gelatin bionanocomposite based on multifunctional TiO2/Ag-NPs for parchment preservation
Authors: Saada Nagah S. , Youssef Ahmed. M. , Helmi Fatma Mohamed , Wahba Wafika Noshy , Abdel-Aziz Mohamed S. 
Published: December 2023

AbstractA significant factor affecting the mechanical, chemical, and visual characteristics of historical parchment is biodeterioration. In order to treat and shield parchment samples from microbial and UV light degradation, gelatin, a biodegradable polymer, loaded with titanium dioxide/silver (TiO2/Ag-NPs) nanocomposites was utilized as a protective coating. TEM and XRD were used to characterize the synthesized nanocomposite, and it was subjected to antimicrobial activity tests, via disc agar plate diffusion and colony-forming units (CFU) technique, against a variety of microbes, including Aspergillus fumigatus N1, Byssochlamys spectabilis N2, Cladosporium xanthochromaticum SPN, and Streptomyces albidoflavus SP11, which had been previously isolated from historical parchment manuscripts. Samples that were not treated served as the negative control, while samples that were separately treated with titanium dioxide and silver served as the positive control. The findings revealed that the TiO2/Ag-NPs/gelatin nanocomposite (NCG) demonstrated remarkable antimicrobial properties in contrast to TiO2NPs, which demonstrated only a minor antimicrobial activity. Investigations were also conducted into the treated parchment’s morphological, chemical, mechanical, and optical qualities. Without compromising any of its characteristics, the prepared film can shield the treated parchment from microbial attack and slow down its accelerated aging process.
Obesity and Leukemia: Biological Mechanisms, Perspectives, and Challenges
Authors: Tsilingiris Dimitrios , Vallianou Natalia G. , Spyrou Nikolaos , Kounatidis Dimitris , Christodoulatos Gerasimos Socrates , Karampela Irene , Dalamaga Maria 
Published: December 2023

Abstract
Purpose of Review
To examine the epidemiological data on obesity and leukemia; evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic leukemia (ALL) survivors; assess the potential mechanisms through which obesity may increase the risk of leukemia; and provide the effects of obesity management on leukemia. Preventive (diet, physical exercise, obesity pharmacotherapy, bariatric surgery) measures, repurposing drugs, candidate therapeutic agents targeting oncogenic pathways of obesity and insulin resistance in leukemia as well as challenges of the COVID-19 pandemic are also discussed.

Recent Findings
Obesity has been implicated in the development of 13 cancers, such as breast, endometrial, colon, renal, esophageal cancers, and multiple myeloma. Leukemia is estimated to account for approximately 2.5% and 3.1% of all new cancer incidence and mortality, respectively, while it represents the most frequent cancer in children younger than 5 years. Current evidence indicates that obesity may have an impact on the risk of leukemia. Increased birthweight may be associated with the development of childhood leukemia. Obesity is also associated with worse outcomes and increased mortality in leukemic patients. However, there are several limitations and challenges in meta-analyses and epidemiological studies. In addition, weight gain may occur in a substantial number of childhood ALL survivors while the majority of studies have documented an increased risk of relapse and mortality among patients with childhood ALL and obesity. The main pathophysiological pathways linking obesity to leukemia include bone marrow adipose tissue; hormones such as insulin and the insulin-like growth factor system as well as sex hormones; pro-inflammatory cytokines, such as IL-6 and TNF-α; adipocytokines, such as adiponectin, leptin, resistin, and visfatin; dyslipidemia and lipid signaling; chronic low-grade inflammation and oxidative stress; and other emerging mechanisms.

Summary
Obesity represents a risk factor for leukemia, being among the only known risk factors that could be prevented or modified through weight loss, healthy diet, and physical exercise. Pharmacological interventions, repurposing drugs used for cardiometabolic comorbidities, and bariatric surgery may be recommended for leukemia and obesity-related cancer prevention.
Non-alcoholic fatty liver disease in obese subjects as related to increasing insulin resistance and deteriorating glucose control: Three years of follow-up from a longitudinal survey
Authors: Forst Thomas , Botz Isabel , Berse Matthias , Voswinkel Stephan , Strempler Mares-Elaine , Baumann Sybille , Marinez Maria 
Published: December 2023

Abstract
Purpose
This observational trial was performed to evaluate liver parameters in overweight or obese subjects in the context of insulin resistance and glucose control over time.

Subjects/Methods
Insulin resistance, glucose control and several parameters for liver integrity were monitored in 177 overweight (BMI > 28 kg/m2) subjects over a mean of 30 months. Volunteers were categorized according to insulin resistance (HOMAIR score) and glucose control in subjects with normal glucose control (NGT), impaired glucose control (IGT), or diabetes mellitus type 2 (T2DM). Liver fat and fibrosis were evaluated by sonographic elastography (FibroScan®) and clinical scores, such as the AST/ALT ratio, fatty liver index (FLI), and NAFLD fibrosis score (NFS).

Results
Liver fat fraction as estimated by the controlled attenuation parameter (CAP), and the FLI were significantly higher in subjects with T2DM compared to IGT and NGT. While fasting insulin levels and the HOMAIR score continuously increased over time, no change in CAP or FLI occurred during follow up. CAP was correlated with FLI (r = 0.50; p < 0.0001) and the HOMAIR score (r = 0.32; p < 0.0001). An inverse correlation was observed between serum adiponectin levels and FLI (r = -0.37; p < 0.0001), the HOMAIR score (r = -0.19; p < 0.001, and CAP (r = -0.15; p < 0.01).

Conclusions
In subjects with a BMI ≥ 28 kg/m2, liver fat fraction is significantly elevated in those with T2DM compared to IGT or NGT. Liver fat fraction is associated with deteriorating insulin sensitivity and loss of glucose control. Despite a continuous increase in insulin resistance, no change in liver fat content or stiffness occurred over 30 months.
Evaluation of cryotherapy and meristem isolation from stolons to eliminate viruses in Fragaria germplasm
Authors: Wöhner Thomas , Höfer Monika 
Published: December 2023

AbstractViral infections pose significant threats to strawberry production. This study explored the efficacy of cryopreservation of shoot tips and meristem isolated from stolons to eradicate strawberry viruses, namely strawberry mottle virus (SMoV), strawberry mild yellow edge virus (SMYEV), strawberry crinkle virus (SCV), and strawberry vein banding virus (SVBV). The occurrence of viruses was verified by RT-PCR with specific primers. Results documented the elimination of SMoV and SCV but not of SMYEV and SVBV by cryotherapy and meristem isolation, showing that both methods can lead to the elimination, in a virus specific manner, of viruses in strawberry.