bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined repetitive facilitative exercise under continuous neuromuscular electrical stimulation and task-oriented training for hemiplegic upper extremity during convalescent phase after stroke: before-and-after feasibility trial
Authors: Fujimoto Koya , Ueno Makoto , Etoh Seiji , Shimodozono Megumi 
Published: February 2024

IntroductionWhereas repetitive facilitative exercise (RFE) affects primarily recovery of motor impairment after stroke, task-oriented training (TOT) focuses on facilitating daily use of the affected upper extremity. However, feasibility of combined RFE and TOT has not been reported. We originated “task-oriented RFE,” as a new combination therapy for patients with hemiplegic upper extremity after subacute stroke, to examine its feasibility in convalescent rehabilitation wards.MethodsThis is a before-and-after pilot study. Eight patients with hemiplegic upper extremity after subacute stroke received the task-oriented RFE program for 6 weeks at 80 min per day (20–60 min of TOT applied after 60–20 min of RFE under continuous neuromuscular electrical stimulation) in a convalescent rehabilitation ward. In the current program, we introduced the Aid for Decision-making in Occupation Choice (ADOC) iPad application as a goal-setting method for determining tasks. Feasibility was assessed with adherence to the protocol, adverse events in response to the intervention, and preliminary efficacy. Motor functions, amount of use and quality of movement in the hemiparetic upper extremity, and satisfaction of the patients were evaluated with Fugl-Meyer Assessment (FMA), the Action Research Arm Test (ARAT), the motor activity log (MAL) for the amount of use (AOU) and quality of movement (QOM) of the paralyzed hand, and ADOC.ResultsAll participants accomplished the program, which was implemented as originally planned; neither nonattendance nor an adverse event occurred during the study. Favorable outcomes were obtained with all measures; mean changes in FMA, ARAT in the dominant hand, MAL-AOU, and MAL-QOM were greater than minimal clinically important differences. Mean changes in ADOC were greater than the minimal detectable change.DiscussionThe task-oriented RFE program was safe, well-tolerated, beneficial, and feasible within 80 min a day of occupational therapy, which means also within the procedural constraints of the Japanese health insurance system during the convalescent phase. Future studies are warranted to examine whether combined RFE and TOT enhances the efficacies of each program alone.
Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment
Authors: Liu Fan , Yan Weiheng , Chen Chen , Zeng Yubing , Kong Yaru , He Xuejia , Pei Pei , Wang Shan , Zhang Ting 
Published: February 2024

IntroductionChronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in the hippocampus and its specific effects on hippocampal function and behavior remain poorly understood.MethodsTo address this gap, we conducted a study using liquid chromatography-tandem mass spectrometry to analyze the lysine acetylome and proteome of the hippocampus in healthy adult mice exposed to intermittent hypoxia for 4 weeks (as a CIH model) compared to normoxic mice (as a control).ResultsWe identified and quantified a total of 2,184 lysine acetylation sites in 1,007 proteins. Analysis of these acetylated proteins revealed disturbances primarily in oxidative phosphorylation, the tricarboxylic acid (TCA) cycle, and glycolysis, all of which are localized exclusively to mitochondria. Additionally, we observed significant changes in the abundance of 21 proteins, some of which are known to be associated with cognitive impairments.DiscussionThis study helps to elucidate the molecular mechanisms underlying CIH-induced changes in protein acetylation in the hippocampus. By providing valuable insights into the pathophysiological processes associated with CIH and their impacts on hippocampal function, our findings contribute to a better understanding of the consequences of CIH-induced changes in protein acetylation in the hippocampus and the potential role of CIH in cognitive impairment.
Prediction by a multiparametric magnetic resonance imaging-based radiomics signature model of disease-free survival in patients with rectal cancer treated by surgery
Authors: Mao Jiwei , Ye Wanli , Ma Weili , Liu Jianjiang , Zhong Wangyan , Yuan Hang , Li Ting , Guan Le , Wu Dongping 
Published: February 2024

ObjectiveThe aim of this study was to assess the ability of a multiparametric magnetic resonance imaging (MRI)-based radiomics signature model to predict disease-free survival (DFS) in patients with rectal cancer treated by surgery.Materials and methodsWe evaluated data of 194 patients with rectal cancer who had undergone radical surgery between April 2016 and September 2021. The mean age of all patients was 62.6 ± 9.7 years (range: 37–86 years). The study endpoint was DFS and 1132 radiomic features were extracted from preoperative MRIs, including contrast-enhanced T1- and T2-weighted imaging and apparent diffusion coefficient values. The study patients were randomly allocated to training (n=97) and validation cohorts (n=97) in a ratio of 5:5. A multivariable Cox regression model was used to generate a radiomics signature (rad score). The associations of rad score with DFS were evaluated using Kaplan–Meier analysis. Three models, namely a radiomics nomogram, radiomics signature, and clinical model, were compared using the Akaike information criterion.ResultThe rad score, which was composed of four MRI features, stratified rectal cancer patients into low- and high-risk groups and was associated with DFS in both the training (p = 0.0026) and validation sets (p = 0.036). Moreover, a radiomics nomogram model that combined rad score and independent clinical risk factors performed better (Harrell concordance index [C-index] =0.77) than a purely radiomics signature (C-index=0.73) or clinical model (C-index=0.70).ConclusionAn MRI radiomics model that incorporates a radiomics signature and clinicopathological factors more accurately predicts DFS than does a clinical model in patients with rectal cancer.
Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents
Authors: Huang Hengye , Zhang Kelvin Pengyuan , Sun Karol Kexin , Yu Guangjun 
Published: February 2024

BackgroundEvidence of the association of certain neurodevelopmental disorder with specific type 2 inflammatory (T2) disease has been found. However, the association of various neurodevelopmental disorders with T2 diseases as a whole remains unclear in low-birth-weight (LBW) infants.ObjectiveTo evaluate the association of type 2 inflammatory (T2) diseases with intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and learning disability (LD) in LBW children and adolescents.MethodsThe study sample was derived from 2005 to 2018 National Health Interview Survey sample child files. LBW children and adolescents aged 3–17 were included. History of T2 diseases (including asthma and atopic dermatitis) and four neurodevelopmental disorders were reported by adults in families. The relationship between T2 diseases and the risk of four neurodevelopmental disorders was investigated through multiple-weighted logistic regression. Age, sex, race/ethnicity, region, highest education in family and ratio of family income to the poverty threshold were adjusted as covariates for model estimation. Subgroup analyses were conducted by age stratification (3–11 and 12–17 years), sex (male and female), and race (white and non-white).Results11,260 LBW children aged 3–17 years [mean age (SE), 9.73 (0.05) years] were included, in which 3,191 children had T2 diseases. History of T2 diseases was associated with an increased risk of neurodevelopmental disorders, with an OR of 1.35 (95% CI, 0.99–1.84) for ID, 1.47 (95% CI, 1.05–2.05) for ASD, 1.81 (95% CI, 1.51–2.16) for ADHD, and 1.74 (95% CI, 1.49–2.04) for LD following the adjustment of all the covariates. The correlations between T2 disorders and each of the four neurodevelopmental disorders were significantly different by sex and race (all P for interaction &lt; 0.001), and no differences were found in age stratification (all P for interaction &gt; 0.05).ConclusionIn a nationally representative sample of children, we found a significant association of T2 diseases with ASD, ADHD, and LD, even after adjusting for demographic baseline. We also found that the association of T2 disease with neurodevelopmental disorders differed between sex and race. Further investigation is needed to evaluate causal relationships and elucidate their potential mechanisms.
Survival analysis of PLWHA undergoing combined antiretroviral therapy: exploring long-term prognosis and influencing factors
Authors: Pu Jun-fan , Wu Jing 
Published: February 2024

IntroductionThe survival time of human immunodeficiency virus (HIV)–infected individuals or patients with acquired immunodeficiency syndrome (AIDS) is influenced by multiple factors. Studying survival and influential factors after antiretroviral therapy (ART) contributes to improving treatment protocols, management strategies, and prognosis for people living with HIV/AIDS (PLWHA).MethodsThis retrospective cohort study collected case data and follow-up records of PLWHA who received ART in Dazu District, Chongqing City, between 2007 and 2022. Cumulative survival rates were calculated using life tables. Survival curves were plotted using the Kaplan–Meier method. Uni-variable and multivariable Cox proportional hazards models analyzed factors influencing survival.ResultsThe study included 5,237 PLWHA receiving ART. Within the first year of ART initiation, 146 AIDS-related deaths occurred, accounting for 29.49% (146/495) of total deaths. Cumulative survival rates at 1, 5, 10, and 15 years were 0.97, 0.90, 0.85, and 0.79, respectively. During the observation period, male patients who received ART had a 1.89 times higher risk of death compared to females (aHR, 1.89; 95%; CI, 1.50–2.37). Patients aged ≥60 years had a 3.44-fold higher risk of death than those aged &lt;30 years (aHR, 3.44; 95% CI, 1.22–9.67). Injection drug users (aHR, 4.95; 95% CI, 2.00–12.24) had a higher risk of death than those with heterosexual (aHR, 1.60; 95% CI, 0.69–3.72) and homosexual transmission. Patients with a baseline CD4+ T lymphocyte count &lt;200 cells/μL (aHR, 8.02; 95% CI, 4.74–13.57) and between 200 and 349 cells/μL (aHR, 2.14; 95% CI, 1.26–3.64) had a higher risk of death than those with ≥350 cells/μL. Patients with ART initiation at WHO clinical stage IV had a 2.48-fold higher risk of death than those at stage I (aHR, 2.48; 95% CI, 1.17–5.23).ConclusionThe first year following ART initiation is critical in HIV/AIDS treatment, emphasizing the need for intensified follow-up and monitoring to facilitate successful immune system reconstruction. Older age, male sex, injection drug use, baseline CD4+ T lymphocyte count &lt;200 cells/μL, and WHO clinical stage IV are associated with an increased risk of death. Tailored treatment and management strategies should be implemented for patient populations at higher risk of mortality and with a poorer prognosis.
Importance of Community Health Workers for Maternal Health Care Management
Authors: Gupta Archana , Khan Saba 
Published: February 2024

Objectives: Community Health Workers (CHWs) are important healthcare professionals and key members of team. The purpose of this research is to identify the roles and responsibilities of CHWs in developed and developing countries who provide healthcare assistance to pregnant and lactating women.Methods: For this particular study, a comparison was conducted between CHWs role in seven developed countries, seven South Asian developing countries, and India, with special emphasis on improving maternal health status.Results: CHW programs are essential in communities, institutional health programs, and outreach delivery systems. Without active community involvement, CHWs cannot reach their full potential. Developed countries have frameworks for CHWs, such as the Swasthya Shebika Program, Village Health Worker Cadret, Lady Health Worker Programme, and Accredited Social Health Activist program. CHWs are well-paid in developed nations and work with marginalized groups to spread health messages. However, up to 60% of community health workers in low- and lower-middle-income countries do not receive remuneration.Conclusion: Health systems must support CHWs in choosing technical interventions and providing necessary training, supervision, and logistical support.
Analisis Performa Pompa Air DAB Tipe DB-125b Sebagai Turbin Dengan Variasi Head Dinamik
Authors: Nabuasa Meinase K , Koehuan Verdy A. , Nurhayati Nurhayati , Jafri Muhamad 
Published: February 2024

Penelitian dilakukan melalui eksperimen terhadap pompa yang difungsikan sebagai turbin dalam penelitian ini adalah pompa regeneratif atau peripheral pump, yaitu pompa air DAB tipe DB-125B. Peripheral pump adalah pompa sentrifugal yang impelernya memiliki sudu-sudu radial dalam jumlah banyak 41 sudu. Kinerja atau performa sistem PAT pompa regeneratif atau peripheral pump, yaitu pompa air DAB tipe DB-125B sebagai pembangkit daya tenaga air dianalisis dengan variasi debit aliran 35 ltr/mnt, 40 ltr/mnt, dan 45 ltr/mnt. Kinerja atau performa sistem PAT pompa regeneratif atau peripheral pump, yaitu pompa air DAB tipe DB-125B sebagai pembangkit daya tenaga air skala kecil dari hasil eksperimen dengan variasi debit aliran menunjukkan daya poros maksimum sebesar 5,849 W dengan debit awal saat tanpa beban sebesar 40ltr/mnt. Penambahan daya air secara langsung dapat meningkatkan putaran poros PAT, begitu juga dengan penambahan debit aliran pada head, putaran rotor turbin juga meningkat. Sedangkan penambahan debit aliran maka daya output dan efisiensi PAT maksimum cenderung terjadi pada putaran yang lebih tinggi dari pada debit aliran yang rendah. Efisiensi PAT pada variasi debit aliran ini mencapai nilai maksimum pada putaran turbin 850,3 rpm sebesar 17,39 %, kemudian diikuti oleh variasi debit aliran 45 ltr/mnt dan 35 ltr/mnt, masing-masing sebesar 11,14 % pada putaran 566,3 rpm dan 8,74 % pada putaran 1440,7 rpm.
PERAN PERKEMBANGAN TEKNOLOGI DIGITAL TERHADAP STRATEGI PEMASARAN DAN DISTRIBUSI UMKM KOTA MAKASSAR
Authors: Astuti Astuti , Mane A. Arifuddin , Saleh Muhammad Yusuf 
Published: February 2024

Penelitian bertujuan untuk mengetahui bagaimana peran perkembangan teknologi digital terhadap strategi pemasaran, distribusi dan umkm dan mengetahui kemajuan teknologi digital pada umkm dan hambatan serta manfaat perkembangan teknologi digital terhadap startegi pemasaran, distribusi dan Umkm Kota Makassar. Penelitian ini menggunakan pendekatan Kualitatif. Teknik pengumpulan data yaitu observasi, wawancara, dan dokumentasi. Data dianalisis menggunakan analisis yaitu melalui reduksi data, penyajian data dan penarikan kesimpulan yang didapatkan oleh peneliti. Teknologi digital memiliki peranan yang besar pada bisnis dan pemasaran kepada lima UMKM (gallery eceng gondok, 89 hidroponik, bobabobi, afstore,sahari cake) . Penggunaan teknologi digital pada konsep pemasaran digital merupakan kombinasi dari strategi online dan juga offline, dimana pemasaran dengan media online harus juga didukung dengan konten offline yang memiliki human-to-human touch sehingga menjadi relevan untuk bisa menciptakan engagement dengan konsumen. Teknologi digital dapat memfasilitasi pengembangan bisnis UMKM di Makassar.
This study aimed to determine the role of digital technology development on the marketing and distribution strategy of MSMEs and to find out the progress of digital technology in MSMEs and the obstacles and benefits of developing digital technology on marketing and distribution Strategy of MSMEs in the city of Makassar. This research used a qualitative approach. Data collection techniques were observation, interview, and documentation. Data were analyzed using analysis, namely through data reduction, data presentation and drawing conclusion obtained by researcher. Digital technology has a big role in business and marketing to five MSMEs (gallery eceng gondok, 89 hidroponik, bobabobi, af store, sahari cake). The use of digital technology in the digital marketing concept is a combination of online and offline strategies, where marketing with online media must also be supported by offline content that has a human-to-human touch so that it becomes relevant to be able to create engagement with consumer.
Tinjauan Atas Prosedur Pengelolaan Persediaan Bahan Baku Pada CV IDS
Authors: Pardede Robert Pius , Aluna Putri Fadella Ari 
Published: February 2024

Inventory management is goods or materials stored in a company that are related to the production process or provision of services, as spare parts or goods that are resold. Inventory can include service costs such as wages and other HR costs directly involved in providing services as well as indirect production allocations. Raw material inventory is the amount of goods or materials available in a company or organization as input in the production or operational process. The purpose of preparing this Final Assignment is to review raw material inventory management procedures consisting of receiving, storing and dispensing raw material activities implemented by CV IDS. The results of this review show that the raw material inventory management procedures at CV IDS have been implemented well. In the procedure for receiving raw materials, the company requires purchase order (PO) and receipt report (RR) documents. And for raw material disbursement procedures, companies need a raw material disbursement book that is separate from the raw material receipt book.

Keywords: raw material inventory, raw material receiving, raw material storage, raw material dispensing.
Perancangan Sistem Informasi Manajemen Stok Gudang Dengan Metode Object Oriented Analysis Design
Authors: Mulyana Ade 
Published: February 2024

An information system is a collection of information contained in a database using information technology models and media used in decision making within a company. In a company, information is something that is important to support the decision-making process by management. Every company or shop must be familiar with inventory or stock of goods. Inventory is the stock of goods which is usually related to the sales and purchasing departments. PT. Bayu Ardi Triyana is a company operating in the IT Solution sector which still uses manual methods to collect data on outgoing and incoming stock so that many errors can occur and result in stock differences between the written data and the goods in the warehouse. Therefore, a system for recording stock availability, incoming and outgoing goods is needed at PT Bayu Ardi Triyana to assist in its business processes. With the system built, it is hoped that it will be able to improve company performance. Object Oriented Analysis Design (OOAD) is an analysis method that examines requirements from the perspective of classes and objects encountered within the scope of the problem that directs software architecture based on the manipulation of system or subsystem objects. OOAD is a new way of thinking about a problem by using models created according to concepts around the real world. The basis for creation is an object which is a combination of data structure and behavior in one entity.

Keywords: Application, Warehouse, Storage, Website
Rancangan Bangun Aplikasi Sales Data Collection System Berbasis Website
Authors: Mulyana Ade , Hermawan Yanto 
Published: February 2024

Megmilk Snow Brand Indonesia is a company that produces milk-based foods (cheese processing) with the well-known brand MEG Cheese. PT Anugerah Raja Terkini is one of the outsourcing companies that collaborates with PT. Megmilk Snow Brand Indonesia. PT Anugerah Raja Terkini itself is responsible for sales activities at the Sales Promotion Girl level. Currently, PT. Anugerah Raja Terkini monitors its SPG only using WhatsApp media. PT. Anugerah Raja Terkini cannot confirm whether the sales are genuine or fictitious, and the admin takes a relatively long time to create a sales report. To be able to overcome this problem, an information system is needed that can support sales data collection activities at PT. Recent King's Awards. The aim of this data collection system is that sales personnel can work better and the sales reporting process can run more quickly and accurately.

Keywords: application, sales data, data collection, system
Komunikasi Antarbudaya Antara Masyarakat Pribumi Dengan Masyarakat Transmigrasi Di Desa Kedataran Kecamatan Maje Kabupaten Kaur
Authors: Pardela Peko Andri , Yanto Yanto , Octaviani Vety 
Published: February 2024

Cultural diversity gave birth to many different cultures in Bengkulu Province, one of which is in Kedataran Village, Maje District, Kaur Regency. In the communication process between people of different cultures, a more comprehensive understanding is needed so that it does not become a conflict. This underlies the research conducted in Kedataran Village, with the aim of describing the intercultural communication process that occurs between indigenous people and transmigration communities in this area. This type of research is field research with a qualitative approach. Data collection techniques were interviews with key and main informants, as well as observation and documentation. This research uses the theory of intercultural communication (Ting-Toomey, 1985) which includes symbolic exchange, proces, different cultural communities, interactive situation, negotiate shared meanings, and societal embedded system. Based on the results of research and data analysis, it is concluded that 1) the use of intercultural communication symbols in Kedataran Village is the language used, namely Kaur, Javanese, and Indonesian, 2) although there are cultural differences but people are able to understand each other so that the communication process is quite harmonious, 3) different cultural communities between people coexist by applying mutual tolerance and mutual respect for differences, 4) interactive situations of intercultural communication during weddings, official village forums, and social activities, 5) negotiation of meaning is related to the substance of the issues conveyed such as conflicts due to differences in viewpoints and assessments of other cultures, 6) systems embedded in society shape the process as well as the results of intercultural encounters between indigenous and transmigration communities.