bluuebunny/crossref_metadata_2025_split huggingface dataset:
4  The impact of different resuscitation fluids on cellular energy metabolism in traumatic injury and haemorrhagic shock
Authors: Cottey Laura , Crossland Hannah , Mallinson Joanne , Greenhaff Paul , Smith Jason , Watts Sarah 
Published: January 2025

IntroductionTrauma is a leading cause of death and despite trauma care improvements, survival rates remain unchanged for critically injured patients. Cellular energy stress occurs early following trauma, potentially representing a therapeutic target for prolonged care.We aimed to determine the degree of cellular energy stress in two porcine trauma and haemorrhagic shock (THS) models resuscitated with saline, fresh whole blood (FWB) and fresh frozen plasma (FFP).MethodsTwo studies were conducted under the Animals (Scientific Procedures) Act 1986. THS1 involved soft tissue, liver injury and 30% total blood volume haemorrhage; THS2 as before with ongoing haemorrhage (4ml/kg/hr). Resuscitation took place for 450 minutes followed by terminal anaesthesia. Muscle samples for ATP, phosphocreatine (PCr) and lactate content were taken at baseline (neck); and pre-mortem following resuscitation from neck (NIR), non-injured limb (HNS) and injured limb (HS). Descriptive data are reported as mean±standard deviation. A p-value of ≤0.05 determined significance.ResultsThe studies involved 57 animals (THS1, n=29, weight 50.7±1.0kg; THS2, n=28, weight 53.7±2.3kg). There was increased model severity with reduced survival to 450 minutes in THS2 compared to THS1. In both studies, the saline group had the lowest survival.THS2 demonstrated increased cellular energy stress compared to THS1 across all treatment groups and sites, with increased lactate and reduced PCr. ATP content was lower in THS2 at the HNS, p<0.0001, and HS, p=0.002 sites only.In THS2, a statistically significant increase in lactate was observed in the saline group compared to the FWB group, at HNS (p=0.0019) and HS sites (p=0.0075). In THS2, FWB resuscitation only, demonstrated no change in cellular energy from baseline to pre-mortem samples.ConclusionHigh cellular energy stress is observed in a porcine THS model with ongoing bleeding, but FWB administration appears to mitigate that stress. Muscle cellular energy metabolism is a sensitive marker of therapeutics employed to improve survival.
Chronic disease prevalence and preventive care among Ontario social housing residents compared with the general population: a population-based cohort study
Authors: Agarwal Gina , Keshavarz Homa , Angeles Ricardo , Pirrie Melissa , Marzanek Francine , Nguyen Francis , Brar Jasdeep , Paterson J Michael 
Published: January 2025

BackgroundOlder adults living in social housing report poor health and access to healthcare services. This study aimed to estimate the prevalence of chronic diseases, influenza vaccination and cancer screenings among social housing residents versus non-residents in Ontario, Canada.MethodsWe conducted a population-based cohort study for all health-insured Ontarians alive and aged 40 or older as of 1 January 2020. Social housing residents were identified using postal codes. Validated health administrative data case definitions were used to identify individuals with diabetes, hypertension, chronic obstructive pulmonary disease, asthma, congestive heart failure and cardiovascular disease. Influenza vaccination and mammography, Pap and colorectal cancer screenings were identified among screen-eligible residents using health administrative data.ResultsThe prevalence of all chronic diseases was higher among social housing residents across all age groups: 40–59, 60–79 and 80+ years. Influenza vaccination rates in 2018–2019 were lower among social housing residents aged 60–79 and 80+ years. Mammography rates for women aged 50–69 years in 2018–2019 were 10–11% lower among social housing residents across all age groups compared with non-residents. Pap screening rates for women aged 40–69 in 2018–2019 were 6–8% lower among social housing residents. The percentage of colorectal screening in both women and men aged 52–74 was lower (9–10% in men and 6–7% in women) in social housing compared with the general population in 2019–2020.ConclusionThere is a higher prevalence of chronic diseases and lower cancer screening rates among the growing population of older adults in social housing in Ontario, Canada.
Association between biosecurity and zoonotic transmission of LA-MRSA CC398 from industrial pig farms to farm workers and their household members
Authors: Bager Peter , Zohorul Islam Md , Urth Tinna Ravnholt , Guardabassi Luca , Damborg Peter , Espinosa-Gongora Carmen , Madsen Anne Mette , Sieber Raphael Niklaus , Bækbo Poul , Skov Robert , Larsen Jesper 
Published: January 2025

BackgroundZoonotic transmission of livestock-associated methicillin-resistantStaphylococcus aureusclonal complex 398 (LA-MRSA CC398) from industrial pig farms to farm workers and their household members and secondary transmission to elderly and immunocompromised persons has led to a growing number of serious infections and even death.ObjectiveWe tested the hypothesis that conventional pig farms confer a higher risk for LA-MRSA CC398 carriage among farm workers and their household members than specific pathogen-free (SPF) farms, which follow a set of stringent rules concerning biosecurity, health control and transportation of pigs between herds.MethodsWe conducted a cross-sectional study of farm workers and their household members from 25 Danish pig farms positive for LA-MRSA CC398. Questionnaires were designed to obtain information about each farm and participant. Nasal samples from pigs and human volunteers were screened for LA-MRSA CC398. Multivariate logistic regression analyses were used to calculate adjusted ORs (aORs) and 95% CIs.ResultsThe study included 25 pig farms, 154 farm workers screened at the farm (93 of whom were also screened at home) and 173 household members. The risk of LA-MRSA CC398 carriage among farm workers at the farm (aOR=5.40, 95% CI 1.05 to 27.80) and household members (aOR=8.32; 95% CI 2.81 to 24.63) was significantly higher in conventional pig farms than in SPF farms.ConclusionsThis study shows that strict biosecurity measures reduce the risk of LA-MRSA CC398 carriage among farm workers and their household members and thereby the disease burden in the general population.
Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy?
Authors: Woelders Eva Christine Ida , Onuma Yoshinobu , Ninomiya Kai , O’Leary Neil , Damman Peter , Peeters Denise Adriana Maria , Hof Arnoud Willem Johannes van 't , Valgimigli Marco , Vranckx Pascal , Windecker Stephan , Serruys Patrick Washington J C , van Geuns Robert-Jan Matthijs 
Published: January 2025

Background and aimsDue to the multitude of risk factors outlined in the guidelines, personalised dual antiplatelet therapy (DAPT) guidance after percutaneous coronary intervention (PCI) is complex. A simplified method was created to facilitate the use of risk stratification. We aimed to compare the predictive and prognostic value of the ‘Zuidoost Nederland Hart Registratie’ (ZON-HR) classification for bleeding risk with the PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent DAPT (PRECISE-DAPT) score and to determine the effect of ticagrelor monotherapy versus DAPT in patients with or without high bleeding risk (HBR).MethodsA post hoc analysis of the GLOBAL LEADERS trial was performed to compare the predictive value of the ZON-HR classification with the PRECISE-DAPT score. Also, the outcomes stratified by either method were compared and the interaction of HBR on the treatment effect was determined.ResultsThe required parameters for the ZON-HR classification (3.7% HBR) and PRECISE-DAPT score (16.6% HBR) were available in 99.9% and 93% of the patients, respectively. The ZON-HR classification had a lower sensitivity (0.09 vs 0.26) and a higher specificity (0.97 vs 0.84), positive predictive value (0.13 vs 0.08) and accuracy (0.92 vs 0.82). Regression analysis showed that both methods predicted hazard for bleeding risk with HRs of 1.87 (95% CI: 1.59 to 2.18) and 2.67 (95% CI: 2.10 to 3.41) for the PRECISE-DAPT score and ZON-HR classification, respectively. The omission of aspirin reduced bleeding events only in acute coronary syndrome (ACS) patients without HBR (HR: 0.74, 95% CI: 0.61 to 0.90, p value for interaction of HBR: 0.04).ConclusionsStratification for bleeding risk according to the ZON-HR classification was feasible in almost all patients and showed to be more conservative than the PRECISE-DAPT score with a consistent prognostic accuracy. The benefit of aspirin omission was the largest in ACS patients without HBR.Trial registration numberNCT01813435.
Two-body hidden charm decays of D wave charmonia
Authors: Qi Xiao-Yu , Wu Qi , Guo Xing-Dao , Chen Dian-Yong 
Published: January 2025

Abstract
The experimental observations of

$$\psi _2(3823)$$

ψ
2

(
3823
)

and

$$\psi _3(3842)$$

ψ
3

(
3842
)

make D wave charmonia family abundant. In the present work, we investigate the hidden charm decay processes of spin triplets of the D-wave charmonia with the meson loop mechanism. The model parameter

$$\alpha _\Lambda $$

α
Λ

is determined by reproducing the branching fraction of

$$\psi (3770)\rightarrow J/\psi \eta $$

ψ
(
3770
)
→
J
/
ψ
η

. With this range of model parameter values, the branching fractions (partial widths) of

$$\psi (3770) \rightarrow \eta _c \omega $$

ψ

(
3770
)

→

η
c

ω

,

$$\psi _2(3823)/\psi _3(3842) \rightarrow J/\psi \eta $$

ψ
2

(
3823
)

/

ψ
3

(
3842
)

→
J
/
ψ
η

,

$$\psi _2(3823)/\psi _3(3842) \rightarrow \eta _c \omega $$

ψ
2

(
3823
)

/

ψ
3

(
3842
)

→

η
c

ω

are estimated. Our estimations find that the partial width of

$$\psi _2(3823) \rightarrow J/\psi \eta $$

ψ
2

(
3823
)

→
J
/
ψ
η

is

$$\left( 29.64^{+4.01}_{-4.63}\right) \ \textrm{keV}$$

29
.

64

-
4.63

+
4.01

keV

, and the partial width ratio of

$$\psi _2(3823) \rightarrow J/\psi \eta $$

ψ
2

(
3823
)

→
J
/
ψ
η

relative to

$$\psi _2(3823)\rightarrow \gamma \chi _{c1}$$

ψ
2

(
3823
)

→
γ

χ

c
1

is about

$$10\%$$

10
%

, which could be tested by further precise measurements from the BESIII, Belle II and LHCb Collaborations.
Determination of $$\mathcal{C}\mathcal{P}$$-violating HZZ interaction with polarised beams at the ILC
Authors: Li Cheng , Moortgat-Pick Gudrid 
Published: January 2025

Abstract
We study possible

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation effects of the 125 GeV Higgs to Z boson coupling at the 250 GeV ILC with transverse and longitudinal beam polarisation via the process

$$e^+ e^- \rightarrow HZ \rightarrow H \mu ^-\mu ^+$$

e
+

e
-

→
H
Z
→
H

μ
-

μ
+

. We explore the azimuthal angular distribution of the muon pair from the Z boson decay, and constructe

$${\mathcal{C}\mathcal{P}}$$

C
P

-odd observables sensitive to

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation effects, where we derived this observable both by analytical calculations and by simulations. Particularly, we can construct two

$${\mathcal{C}\mathcal{P}}$$

C
P

-odd observables with the help of transversely-polarised initial beams and improve the statistical significance of

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation effects by combining two measurements. We defined the asymmetries between the signal regions with different signs of the

$${\mathcal{C}\mathcal{P}}$$

C
P

-odd observables, and determine the

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation effect by comparing with the SM 95% CL upper bound. In this paper, we setup a scenario which assumes that the total cross-section is always fixed while

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation is varying, and such a scenario helps us to determine the intrinsic

$${\mathcal{C}\mathcal{P}}$$

C
P

-mixing angle limit around

$$|\xi _{\mathcal{C}\mathcal{P}}|\sim 0.03~{\operatorname {rad}}$$

|

ξ

C
P

|
∼
0.03

rad

with (90%, 40%) polarised electron-positron beams and 5

$$\hbox {ab}^{-1}$$

ab

-
1

integrated luminosity. In addition, we determine the

$${\mathcal{C}\mathcal{P}}$$

C
P

-odd coupling limit

$$|\widetilde{c}_{HZZ}|\sim 0.01$$

|

c
~

HZZ

|
∼
0.01

as well, where we suppose that the SM tree-level cross-section is fixed and the

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation is the varying additional contribution. Comparing with the analysis with unpolarised beams, the sensitivity to the

$${\mathcal{C}\mathcal{P}}$$

C
P

-violation effect can be improved by transverse or longitudinal polarisation.
Case 333: Masson Tumor
Authors: Krishnan Venkatram , Rana Abhilasha , Nix James , Damalcheruvu Prashanth 
Published: January 2025

History A 61-year-old male patient without prior history of ophthalmologic problems presented with pain and redness in the left eye associated with slowly progressive proptosis over the previous 6 months. The patient also had diplopia in rightward and downward gaze. There was no vision loss. Mild fullness was seen in the periorbital tissues without any redness or fluctuance and with no purulent discharge from the left eye. The patient was otherwise healthy, with a 6-year history of diabetes mellitus and an 8-year history of hypertension managed well with medication. There was no history of trauma to the head or face. At clinical examination, conjunctival edema and redness with proptosis were noted. The cornea was clear. Evaluation of eye movements revealed restricted motion of the left eye in medial gaze and downward gaze. Ophthalmoscopic evaluation did not show any substantial abnormality. The retina and retinal vascularity were unremarkable. The right eye was unremarkable. Uncorrected visual acuity was 20/30 in the right eye and 20/40 in the left eye. Corrected visual acuity was 20/20 in both eyes. Complete blood cell count, as well as liver and kidney function test results, were within normal limits. The erythrocyte sedimentation rate and C-reactive protein level were normal. Thyroid function test results were normal. The patient subsequently underwent CT of the orbits without and with contrast enhancement followed by further evaluation with MRI of the orbits without and with contrast enhancement.
Beyond Citations: Measuring Novel Scientific Ideas and their Impact in Publication Text
Authors: Arts Sam , Melluso Nicola , Veugelers Reinhilde 
Published: January 2025

Abstract
New scientific ideas drive progress, yet measuring scientific novelty remains challenging. We use natural language processing to detect the origin and impact of new ideas in scientific publications. To validate our methods, we analyze No-bel Prize-winning papers, which likely pioneered impactful new ideas, and lit-erature review papers, which typically consolidate existing knowledge. We also show that novel papers have more intellectual neighbors published after them, indicating they are ahead of their intellectual peers. Finally, papers introducing new ideas, particularly those with greater follow-on reuse, attract more citations.
Suhexiang pill for acute ischemic stroke in real-world practice setting (SUNRISE): protocol of a multicenter registry
Authors: Lai Xinxing , Xiong Xuejiao , Jia Qi , Liu Tingting , Yang Zhaowen , Zhang Chi , Kong Lingbo , Cao Kegang , Dong Ting , Fang Caixia , Ge Jianwen , Dong Li , Zong Zhitao , Chen Sisi , Ma Yuhong , Bai Xue , Wu Dahua , Xie Yao , Zhang Mingyan , Wang Yilong , Jiang Guohui , Song Daqiao , Wang Yanping , Gui Chunyan , Geng Qingwen , Gao Ying ,   for the SUNRISE study investigators
Published: January 2025

Abstract

Background
Suhexiang (SHX) pill is widely used for treating acute ischemic stroke (AIS). Experimental and randomized controlled trials suggested that SHX pill was beneficial for patients with AIS. However, the effectiveness of SHX pill in real-world practice setting remains unclear. It is of great importance to investigate the effectiveness and safety of SHX pill in patients with acute ischemic stroke in real-world clinical practice with long-term follow-up.

Methods
The Suhexiang pill for acute ischemic stroke in Real-world Practice Setting (SUNRISE) is a multicenter, prospective, product-specific, observational study designed to provide insight into the administration of SHX pill for patients with AIS in the real-world clinical practice setting, with an initial sample size of 1000. Eligible patients treated with SHX pill within seven days of AIS onset will be consecutively included in this registry. The primary outcome is the proportion of patients independent at 3 months after stroke onset defined by an mRS score of 0, 1, or 2.

Conclusion
The findings of the SUNRISE registry will not only provide insights into the characteristics of patients who may benefit from SHX treatment, but also may enable the individualized treatment decision-making of SHX pill in real-world practice setting.

Study registration
This study was registered with the ClinicalTrials.gov (URL: https://clinicaltrials.gov/, Unique identifier: NCT05833932).
Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn.
Authors: Sobhy Marina , Kirollos Farid N. , AbouZid Sameh F. , Ismail Nasser S. M. , El-Shiekh Riham A. , Abdel-Sattar Essam 
Published: January 2025

Abstract

Duranta erecta Linn. belongs to the Verbenaceae family and is primarily found in subtropical, tropical, and temperate climates. The plant has been reported to contain a variety of phytoconstituents, including iridoid glycosides, flavonoids, flavonoid glycosides, alkaloids, phenolics, tannins, terpenoids, steroids, and saponins. In this investigation, a bioactivity-guided isolation was used to isolate cyclooxygenases (COXs) and lipoxygenase (LOX)-inhibiting compounds from the leaves of Duranta erecta Linn. Duranterectoside A (1), lamiide (2), and apigenin 4’,7-dimethyl ether (3) were identified employing spectroscopic methods (including ESI-MS, 1H-NMR, and 13C-NMR), and by comparing with existing literature data. This is the first report of metabolitrs from D. erecta inhibiting both LOX and COX enzymes. Furthermore, the isolated compounds were analyzed using computerized virtual screening, which enabled the modelling ADME characteristics, molecular docking, and dynamics simulation. The results demonstrated that compound 1 had greater docking scores than the docked lead compounds. Overall, the data reported in this study add to our understanding of the pharmacological properties of the examined plant and Duranterectoside A (1) and pave the way for future research and investigation in inflammation and drug discovery.
A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy
Authors: Schulte Andreas , Brockmann Janik , Müller Nina , Anderlei Tibor , Büchs Jochen 
Published: January 2025

Abstract

Background
Shake flasks are essential tools in biotechnological development due to their cost efficiency and ease of use. However, a significant challenge is the miniaturization of process analytical tools to maximize information output from each cultivation. This study aimed to develop a respiration activity online measurement system via off-gas analysis, named “Transfer rate Online Measurement” (TOM), for determining the oxygen transfer rate (OTR), carbon dioxide transfer rate (CTR), and the respiration quotient (RQ) in surface-aerated bioreactors, primarily targeting shake flasks.

Results
Sensors for off-gas analysis were placed in a bypass system that avoids the shaking of the electronics and sensors. An electrochemical oxygen sensor and an infrared CO2 sensor were used. The bypass system was combined with the established method of recurrent dynamic measurement phases, evaluating the decrease in oxygen and the increase in CO2 during stopped aeration. The newly developed measurement system showed high accuracy, precision and reproducibility among individual flasks, especially regarding CTR measurement. The system was compared with state-of-the-art RAMOS technology (Respiration Activity Monitoring System, see explanation below) and calibrated with a non-biological model system. The accuracy of RQ measurement was +-4% for the tested range (8% filling volume, OTR and CTR: 0–56 mmol/L/h), allowing for the determination of metabolic switches and quantitative analysis of metabolites. At ambient CO2 levels, a CTR resolution of less than 0.01 mmol/L/h was possible. The system was applied to the microbial model systems S. cerevisiae, G. oxydans, and E. coli. Physiological states, such as growth vs. protein production, could be revealed, and quantitative analysis of metabolites was performed, putting focus on RQ measurements.

Conclusions
The developed TOM system showcases a novel approach to measuring OTR, CTR, and RQ in shaken bioreactors. It offers a robust and accurate solution for respiration activity analysis. Due to its flexible design and tunable accuracy, it enables measurement in various applications and different shake flasks.
Effect of temperature cycles on the sleep-like state in Hydra vulgaris
Authors: Sato Aya , Sekiguchi Manabu , Nakada Koga , Yoshii Taishi , Itoh Taichi Q. 
Published: January 2025

Abstract

Background
Sleep is a conserved physiological phenomenon across species. It is mainly controlled by two processes: a circadian clock that regulates the timing of sleep and a homeostat that regulates the sleep drive. Even cnidarians, such as Hydra and jellyfish, which lack a brain, display sleep-like states. However, the manner in which environmental cues affect sleep-like states in these organisms remains unknown. In the present study, we investigated the effects of light and temperature cycles on the sleep-like state in Hydra vulgaris.

Results
Our findings indicate that Hydra responds to temperature cycles with a difference of up to 5° C, resulting in decreased sleep duration under light conditions and increased sleep duration in dark conditions. Furthermore, our results reveal that Hydra prioritizes temperature changes over light as an environmental cue. Additionally, our body resection experiments show tissue-specific responsiveness in the generation ofthe sleep-like state under different environmental cues. Specifically, the upper body can generate the sleep-like state in response to a single environmental cue. In contrast, the lower body did not respond to 12-h light–dark cycles at a constant temperature.

Conclusions
These findings indicate that both light and temperature influence the regulation of the sleep-like state in Hydra. Moreover, these observations highlight the existence of distinct regulatory mechanisms that govern patterns of the sleep-like state in brainless organisms, suggesting the potential involvement of specific regions for responsiveness of environmental cues for regulation of the sleep-like state.
UAV swarms: research, challenges, and future directions
Authors: Alqudsi Yunes , Makaraci Murat 
Published: January 2025

Abstract
Unmanned Aerial Vehicle (UAV) swarms represent a transformative advancement in aerial robotics, leveraging collaborative autonomy to enhance operational capabilities. This paper provides a comprehensive exploration of UAV swarm infrastructure, recent research advancements, and diverse applications. Key areas such as coordinated path planning, task assignment, formation control, and security considerations are examined, highlighting how Artificial Intelligence (AI) and Machine Learning (ML) are integrated to improve decision-making and adaptability. Applications span civilian sectors, including entertainment, infrastructure inspection, and delivery services, as well as military applications in surveillance, combat support, and logistics. The paper addresses technical challenges, regulatory constraints, and ethical considerations, while outlining future directions focused on scalability, robustness, and societal integration. This review consolidates the evolving landscape of UAV swarms, identifying critical challenges and guiding future research endeavors.