bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety‐Like Behavior and Hippocampal Transcriptomic Responses in Male Rats
Authors: Demin Konstantin A. , Kolesnikova Tatiana O. , Galstyan David S. , Krotova Natalia A. , Ilyin Nikita P. , Derzhavina Ksenia A. , Seredinskaya Maria , Nerush Maria , Pushkareva Sofia A. , Masharsky Alexey , de Abreu Murilo S. , Kalueff Allan V. 
Published: February 2025

ABSTRACTChronic stress is a common trigger of multiple neuropsychiatric illnesses. Animal models are widely used to study stress‐induced brain disorders and their interplay with neuroinflammation and other neuroimmune processes. Here, we apply the prolonged 12‐week chronic unpredictable stress (PCUS) model to examine rat behavioral and hippocampal transcriptomic responses to stress and to chronic 4‐week treatment with a classical antidepressant fluoxetine, an anti‐inflammatory agent eicosapentaenoic acid (EPA), a pro‐inflammatory agent lipopolysaccharide and their combinations. Overall, PCUS evoked anxiety‐like behavioral phenotype in rats, corrected by chronic fluoxetine (alone or combined with other drugs), and EPA. PCUS also evoked pronounced transcriptomic responses in rat hippocampi, involving > 200 differentially expressed genes. While pharmacological manipulations did not affect hippocampal gene expression markedly, Gpr6, Drd2 and Adora2a were downregulated in stressed rats treated with fluoxetine, EPA and fluoxetine + EPA, suggesting their respective protein products (G protein‐coupled receptor 6, dopamine D2 receptor and adenosine A2A receptor) as potential evolutionarily conserved targets under chronic stress. Overall, these findings support the validity of rat PCUS paradigm as a useful model to study stress‐related anxiety pathogenesis, and call for further research probing how various conventional and novel drugs may (co)modulate behavioral and neurotranscriptomic biomarkers of chronic stress.
A Deep‐Learning Model for Multi‐class Audio Classification of Vocal Fold Pathologies in Office Stroboscopy
Authors: Kim Yeo E. , Dobko Maria , Li Haomiao , Shao Tianlan , Periyakoil Preethi , Tipton Courtney , Colasacco Christine , Serpedin Aisha , Elemento Olivier , Sabuncu Mert , Pitman Michael , Sulica Lucian , Rameau Anaïs 
Published: February 2025

ObjectiveTo develop and validate a deep‐learning classifier trained on voice data extracted from videolaryngostroboscopy recordings, differentiating between three different vocal fold (VF) states: healthy (HVF), unilateral paralysis (UVFP), and VF lesions, including benign and malignant pathologies.MethodsPatients with UVFP (n = 105), VF lesions (n = 63), and HVF (n = 41) were retrospectively identified. Voice samples were extracted from stroboscopic videos (Pentax Laryngeal Strobe Model 9400), including sustained /i/ phonation, pitch glide, and /i/ sniff task. Extracted audio files were converted into Mel‐spectrograms. Voice samples were independently divided into training (80%), validation (10%), and test (10%) by patient. Pretrained ResNet18 models were trained to classify (1) HVF and pathological VF (lesions and UVFP), and (2) HVF, UVFP, and VF lesions. Both classifiers were further validated on an external dataset consisting of 12 UVFP, 13 VF lesions, and 15 HVF patients. Model performances were evaluated by accuracy and F1‐score.ResultsWhen evaluated on a hold‐out test set, the binary classifier demonstrated stronger performance compared to the multi‐class classifier (accuracy 83% vs. 40%; F1‐score 0.90 vs. 0.36). When evaluated on an external dataset, the binary classifier achieved an accuracy of 63% and F1‐score of 0.48, compared to 35% and 0.25 for the multi‐class classifier.ConclusionsDeep‐learning classifiers differentiating HVF, UVFP, and VF lesions were developed using voice data from stroboscopic videos. Although healthy and pathological voice were differentiated with moderate accuracy, multi‐class classification lowered model performance. The model performed poorly on an external dataset. Voice captured in stroboscopic videos may have limited diagnostic value, though further studies are needed.Level of Evidence4 Laryngoscope, 2025
Agro‐Forestry Integrated Management of Karst Rocky Desertification Control: The Model Establishment and Practices in South China
Authors: Sheng Maoyin , Yang Chunmei , Wang Linjiao 
Published: February 2025

ABSTRACTKarst rocky desertification (KRD) has become the most serious ecological environmental problem in South China. Since 2008, the Chinese government has implemented a special project for KRD control. Because there are large populations in KRD areas of South China who need to survive, KRD control must not only pay attention to the ecological effects of vegetation restoration but also take into account the economic benefits and industrial effects of the local populations' survival needs. Agro‐forestry integrated management can produce remarkable economic effects in vegetation restorations and can play an important role in KRD control. In this review, firstly, the KRD hazards and control in South China were reviewed. The features and advantages of agro‐forestry integrated management were concluded. Then, based on a typical case in South China, the model establishment and practice of agro‐forestry integrated management for KRD control were introduced. The case results showed that agro‐forestry integrated management achieved remarkable ecological and economic benefits in KRD control. Finally, the existing challenges and their optimization strategies of the agro‐forestry integrated management for KRD control were provided. This review provides important clues for scientific KRD control and is of great significance for the sustainable development of the karst region in South China.
The Effect of Perceived Infectious Disease Threats on the Preference of User‐Designed Products
Authors: Zhong Xiuli , Wang Yu , Wang Tao 
Published: February 2025

ABSTRACTThis study investigates the impact of perceived infectious disease threats on consumer preferences for user‐designed products. Drawing on both secondary and experimental data, we demonstrate that infectious disease threats enhance consumer preferences for user‐designed products (Studies 1 and 2), with the desire for self‐reliance mediating this process (Studies 3 and 4). Additionally, consumer mindset moderates this effect (Study 5). The impact of infectious disease threats on user‐designed product preference is evident only in consumers with a growth mindset and not in those with a fixed mindset. This study reveals consumer interest in self‐reliance and user‐designed products in the face of pathogen threats, which can help organizations adopt effective marketing practices to respond to challenges during pathogen epidemics.
Experimentelle und rechnerisch validierte Methode zur Bestimmung der Mindesteinschraubtiefe von Schraubenverbindungen mit gefurchtem Mutterngewinde
Authors: Kraemer F. , Binder T. , Klein M. , Oechsner M. 
Published: February 2025

AbstractDie Einschraubtiefe und die Größe des Vorlochdurchmessers bestimmen neben dem Scherfestigkeitsverhältnis der eingesetzten Werkstoffe die quasi‐statische Beanspruchbarkeit von Schraubenverbindungen mit gefurchtem Gewinde. Zur Validierung eines neuen Bewertungsansatzes zur Bestimmung der erforderlichen Mindesteinschraubtiefe werden Auszugsversuche mit variierter Einschraubtiefe und Gewindeüberdeckung für verschiedene Gewindetypen und Gewindegrößen durchgeführt. In Form des Beanspruchbarkeitsverhältnisses eines perfekt ausgeformten Gewindes und dem eines zu bewertenden Gewindes wird die Gewindeflankenüberdeckung des gefurchten Mutterngewindes in der Auslegung der erforderlichen Mindesteinschraubtiefe berücksichtigt.
Evaluation of mechanical properties for Ricinus communis L plant fiber/epoxy composite
Authors: Egala R. , Dewangan K. , Setti S. G. 
Published: February 2025

AbstractThis research explores the mechanical properties of castor oil plant (Ricinus communis L) natural fiber‐reinforced epoxy composites, addressing the need for sustainable materials. Cortex and xylem fibers extracted from castor oil plant residue using a standardized method were used to fabricate unidirectional long fiber and short random fiber composites. Various fiber volume fractions (10 %, 20 %, 30 %, 40 %) and fiber lengths (5 mm to 40 mm) of cortex fibers were tested according to ASTM standards and results showed that fibers of diameters 275 μm to 325 μm, have superior tensile strength (290 MPa to 346 MPa) compared to xylem fibers (90 MPa to 140 MPa). Composites of 40 % volume fraction cortex fibers aligned longitudinally exhibited the highest tensile (76.35 MPa), flexural (121.45 MPa), and impact strength (6.99 kJ/m2) significantly improved compared to the epoxy matrix. For short random cortex fiber composites, the optimal mechanical performance was achieved with 20 mm fibers and a 40 % volume fraction, resulting in the highest tensile strength (32.12 MPa), flexural strength (84.31 MPa), and impact energy (40 J/m). These results highlight the potential of castor oil cortex fibers to enhance the mechanical properties of epoxy composites for various engineering applications.
Advancement of tribological properties of AA 5083 aluminum matrix composite through the incorporation of micro‐ and nano‐copper ferrite reinforcements synthesized from mulberry leaves (Morus alba L.) using a green synthesis method
Authors: Işıtan A. , Sulak M. , Özen F. , Onar V. 
Published: February 2025

AbstractThis study investigates the enhancement of wear and friction performance in an AA 5083 matrix composite by incorporating copper ferrite (CuFe2O4) micro and nanoparticles, synthesized through a green process using mulberry (Morus alba L.) leaf extract for the first time. Two distinct composites are fabricated using the liquid metallurgy vortex‐route method featuring an aluminum AA 5083 matrix and 0.2 % micro‐ and nano‐ copper ferrite reinforcement by weight. AA 5083 cast alloy under identical conditions. Characterization analyses were conducted to elucidate the composite properties. The composite samples are underwent wear tests against a steel disc under three different loads (10 N, 20 N, and 40 N) at two sliding distances (250 m and 500 m), maintaining a constant sliding speed of 2.6 m/s using a pin‐on‐disc wear test apparatus. The composites exhibited superior wear and friction performance compared to the unreinforced material. Overall, the nano‐copper ferrite reinforced material showcased, on average, 33 % and 52 % lower wear rates than the unreinforced material, and 27 % and 31 % lower wear rates than the micro‐copper ferrite reinforced material respectively.
Effect of micro‐sized blast furnace slag on physical, mechanical, and thermo‐mechanical properties of bi‐directional date palm fiber reinforced polymer composite
Authors: Pradhan M. , Patnaik A. , Banerjee M. K. , Mishra S. 
Published: February 2025

AbstractThis present research work focuses on studying the physical, mechanical, and thermo‐mechanical behavior of blast furnace slag (BFS) in bi‐directional date palm fiber reinforced hybrid polymer composites. During this investigation, the different weight percentage of blast furnace slag filler (from 3 wt.‐% to 7 wt.‐%) was added to date palm fiber to fabricate epoxy‐based composite by vacuum assisted resign transfer molding (VARTM) technique under controlled pressure conditions. The fabricated composite were characterized for physical (density, void content, hardness), mechanical testing (tensile, flexural, inter‐laminar shear strength, impact strength and fracture toughness) and thermal properties. The experimental result indicated varied rate of deterioration for tensile strength of the composites and the maximum tensile strength 69.51 MPa was obtained for blast furnace slag (3 wt.‐%) and date palm fiber (30 wt.‐%) hybrid composite. The optimum flexural and inter laminar shear strength has been obtained to be 85.72 MPa and 9.43 MPa for 7 wt.‐% blast furnace slag‐filled date palm fiber‐epoxy hybrid composite. Similarly, in case of fracture toughness, blast furnace slag‐filled composites, fracture toughness increases by approximately 20 %, 28 %, and 38 % respectively over unfilled composites. Based upon the results of the present research work can be afterward prolonged for automobile components and low‐grade structural application in addition to optimal waste utilization to reduce environmental degradation.
Influences of composite additives and technological parameters on the microstructure and properties of electrolytic copper foil
Authors: Zhang B. , Sun W. C. , Liu E. Y. , Xu Y. F. , Zhou M. R. , Cai H. , Zhang J. L. , Jia T. Z. 
Published: February 2025

AbstractIn this paper, the additives consisting of bis‐(3‐sulfopropyl)‐disulfide, hydroxyethylcellulose and collagen additive compounding are used to fabricate ultra‐thin copper foils with low roughness on titanium substrates. The results show that the deposited layers obtained at the electrodeposition time of 3 min, the electrolyte temperature of 50 °C and the output voltage of 2.5 V exhibit small grain size and good adhesion to the substrate. Meanwhile, the effects of the two‐component additive and the three‐component additive on the microstructures, surface roughness and electrochemical behavior of copper foils are studied. The x‐ray diffraction results reveal that copper foils prepared by simultaneous introduction of 0.06 g/L bis‐(3‐sulfopropyl)‐disulfide and 0.08 g/L collagen possess a dense and homogeneous structure with the smallest grain size and the lowest roughness, which is diminished by 26.17 %. The electrochemical results indicated that the SC additive had an inhibitory effect on the deposition of copper ions, while the SH additive exerted depolarizing effect in this electrolyte system, accelerating the deposition of copper particles, which was attributed to the antagonistic interaction between bis‐(3‐sulfopropyl)‐disulfide and hydroxyethylcellulose that hindered the preferential adsorption of the additive at the surface protrusions, resulting in the decrease in the refinement effect of the bis‐(3‐sulfopropyl)‐disulfide additive. Under the optimized process parameters, the increase in the deposition rate of Cu2+ balances the relationship between nucleation and growth of copper ions, which ultimately produces the copper foil with smooth surface and low roughness.
Long‐Term Outcomes on Pallidal Neurostimulation for Dystonia: A Controlled, Prospective 10‐Year Follow‐Up
Authors: Krause Patricia , Mahlknecht Philipp , Skogseid Inger Marie , Steigerwald Frank , Deuschl Günther , Erasmi Richard , Schnitzler Alfons , Warnecke Tobias , Müller Jörg , Poewe Werner , Schneider Gerd‐Helge , Vesper Jan , Warneke Nils , Eisner Wilhelm , Prokop Thomas , Müller Jan‐Uwe , Volkmann Jens , Kühn Andrea A. ,   for the Deep‐Brain Stimulation for Dystonia Study Group
Published: February 2025

AbstractBackgroundPallidal neurostimulation is an effective treatment for severe isolated dystonia, but long‐term data from clinical trials are lacking.ObjectivesTo evaluate long‐term efficacy and safety of pallidal neurostimulation in patients with isolated generalized or segmental dystonia.MethodsExtension study of the prospective multicenter trial (n = 40; July 2002 to May 2004), all patients received effective stimulation and underwent regular follow‐up. The 10‐year follow‐up (n = 31) included Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) motor and disability score, Beck Depression Inventory, Beck Anxiety Inventory, and Mattis Dementia Rating Scale. Primary and secondary endpoints compared motor symptoms, disability scores, mood, and cognition changes.ResultsThirty‐one patients (12 female), aged 23–72 years, completed the 10‐year study extension. Per protocol analysis showed sustained significant improvement in BFMDRS motor scores at 10 years compared with baseline, without significant change from the 6‐month or 5‐year follow‐up. On average, motor scores decreased by 25.3 ± 5.2 points at 10 years (P < 0.0001; 56% improvement). Individual outcomes varied, with 27 responders (≥25% improvement; mean improvement 65.2 ± 21.4%) and 13 non‐responders compared with baseline. Sustained improvements were seen in disability, mood, and anxiety scores. Cognition remained stable.ConclusionsThis study presents the longest prospective, multicenter follow‐up of pallidal neurostimulation in generalized and segmental dystonia. Two‐thirds of patients showed strong and stable long‐term improvements of dystonia, confirming sustained efficacy and safety over 10 years in treatment‐refractory dystonic patients. However, one‐third experienced primary (3/40) or secondary (10/40) treatment failure. Diagnostic advances, including genetic testing, and technological progress in pallidal neurostimulation may help to reduce the non‐responder rates in the future. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Robust Resilient Base Containment Control of Fractional Order Multiagent Systems With Disturbance and Time Delays
Authors: Alsinai Ammar , Ullah Khan Niazi Azmat , Zeeshan Babar Muhammad , Jamil Airish , Faisal Nujood 
Published: February 2025

ABSTRACTThis article examines the resilient base containment control (CC) for fractional order multiple agent system with disturbance term in the dynamical system. In order to deal with resilient base CC in Riemann–Liouville sense with time delays, a simple and effective method is proposed where followers have weighted digraph topology among them. A disturbance factor is present into both linear and nonlinear delayed RL‐fractional‐order multiple agent systems (FMASs) with distributed time delays. This disturbance term effect the agents by introducing the uncertainty into the behavior of agents. In this article, Lyapunov technique, fractional calculus properties, and analytical methods are used to approach resilient base CC. The major benefit of this approach is that the first‐order derivative of Lyapunov function may be used to keep away from complex calculations, which effectively reduce troubles and difficulties resulting from time delays and fractional derivatives. At the end of our study, three illustration are provided to show the effectiveness and validity of our approach.
Estimates of Approximation Numbers, Nuclearity of the Resolvent of a Third‐Order Singular Differential Operator, and the Completeness of Its Root Vectors
Authors: Muratbekov Mussakan , Muratbekov Madi , Shuitenov Gabit 
Published: February 2025

ABSTRACTIn this paper, we examine a third‐order singular differential operator in the space , with a coefficient which is a continuous function on and exhibits potential growth at infinity. We prove the existence of the operator's resolvent and establish the maximal regularity of the solutions to the equation associated with the operator. We also prove the compactness property of the resolvent and obtain two‐sided bounds for the singular numbers (s‐numbers). These bounds provide the rate at which the resolvent of the operator under consideration can be approximated by finite‐dimensional linear operators. To the best of our knowledge, we establish for the first time the nuclearity of the resolvent for a third‐order differential operator and demonstrate the completeness of the operator's root vectors in the case of an unbounded domain with a rapidly growing coefficient at infinity.
Testing a Personalized Behavioral Weight Loss Approach Using Multifactor Prescriptions and Self‐Experimentation: 12‐Week mHealth Pilot Randomized Controlled Trial Results
Authors: Martinez Caitlin E. , Hatley Karen E. , Polzien Kristen , Diamond Molly , Tate Deborah F. 
Published: February 2025

ABSTRACTBackgroundBehavioral weight loss (WL) interventions typically follow standard diet and activity prescriptions for intervention duration to produce an energy deficit. Though average weight losses in these programs are clinically meaningful, there is heterogeneity in weight outcomes. Personalized diet and activity prescriptions may help increase the potency of WL programs by reducing this heterogeneity.MethodsThis 12‐week pilot study randomized participants (n = 35; BMI 34.6 ± 4.9 kg/m2, 34% with HbA1c 5.7%–6.4%) in a 3:1 ratio to a Personalized Behavioral Weight Loss (PBWL) or standard BWL and compared the feasibility and efficacy of these approaches. Both groups received a study mobile app, smart scale, activity tracker, and weekly telephone coaching sessions; PBWL participants received a continuous glucose monitoring device. PBWL participants had goals for 1) macronutrient composition (low fat or carbohydrate), 2) meal frequency (3 meals or meals and snacks), and 3) activity focus (daily or weekly goal); they experimented with different 3‐part prescriptions, in random order and combination, for the first 4 weeks then picked their 3 goals to follow for weeks 5–12.ResultsStudy retention (100%) and satisfaction were high. Mean 3‐month weight loss (kg) was greater in PBWL (−7.08 (0.74)) than BWL (−3.79 (0.84), P = 0.03); 74% of PBWL and 63% of BWL participants were “optimizers” who achieved a 5% weight loss at 3 months. PBWL optimizers lost more weight (−8.66 (0.66)) than BWL optimizers (−4.76 (0.43), p < 0.001).ConclusionsExperimentally‐derived personalized prescriptions supported greater 12‐week weight loss than standard recommendations.Trial Registration: ClinicalTrials.gov NCT04639076.
Investigations on Local Minimum Problem for Dual‐Quaternion‐Based Sliding Mode Control With Artificial Potential Functions
Authors: Stankovic Ana , Yang Juntang , Huwald Markus , Ben‐Larbi Mohamed Khalil , Müller Wolfgang H. 
Published: February 2025

ABSTRACTThis paper investigates a sliding mode control law based on dual quaternions for six‐degree‐of‐freedom (six‐DOF) proximity operations between a chaser and a target spacecraft. Dual quaternions, which can simultaneously represent both the rotation and translation of rigid bodies, effectively model the coupled relative motion during these operations. The sliding surface design incorporates artificial potential functions, enabling the consideration of motion constraints including field‐of‐view restrictions, approach path constraints, and collision avoidance. However, these functions are prone to local minima, where attractive and repulsive forces balance each other out, leading to undesired convergence. This paper presents a comprehensive mathematical analysis of the local minimum problem, elucidating the impact of individual and combined constraints on the chaser behavior. To address the local minimum issue, an active escape mechanism is proposed to apply additional corrective forces to help the chaser overcome these traps and achieve reliable control. Numerical simulation evaluates the proposed solution, confirming its effectiveness in resolving local minima challenges and enhancing mission reliability.