bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors predicting the progression from paroxysmal to persistent atrial fibrillation despite an index catheter ablation
Authors: Li Guan‐Yi , Elimam Ahmed Moustafa , Lo Li‐Wei , Lin Yenn‐Jiang , Chang Shih‐Lin , Hu Yu‐Feng , Chung Fa‐Po , Chao Tze‐Fan , Lin Chin‐Yu , Liu Chih‐Min , Liao Jo‐Nan , Ton An Khanh‐ Nu , Yugo Dony , Lin Linda , Tuan Ta‐Chuan , Kao Pei Heng , Liu Shin‐Huei , Chhay Chheng , Kuo Ling , Cheng Wen‐Han , Chen Wei‐Tso , Chen Shih‐Ann 
Published: October 2023

AbstractIntroductionDespite undergoing an index ablation, some patients progress from paroxysmal atrial fibrillation (PAF) to persistent AF (PersAF), and the mechanism behind this is unclear. The aim of this study was to investigate the predictors of progression to PersAF after catheter ablation in patients with PAF.MethodsThis study included 400 PAF patients who underwent an index ablation between 2015 and 2019. The patients were classified into three groups based on their outcomes: Group 1 (PAF to sinus rhythm, n = 226), Group 2 (PAF to PAF, n = 146), and Group 3 (PAF to PersAF, n = 28). Baseline and procedural characteristics were collected, and predictors for AF recurrence and progression were evaluated.ResultsThe mean age of the patients was 58.4 ± 11.1 years, with 272 males. After 3 years of follow‐up, 7% of the PAF cases recurred and progressed to PersAF despite undergoing an index catheter ablation. In the multivariable analysis, a larger left atrial (LA) diameter and the presence of non‐pulmonary vein (PV) triggers during the index procedure independently predicted recurrence. Moreover, a larger LA diameter, the presence of non‐PV triggers, and a history of thyroid disease independently predicted AF progression.ConclusionThe progression from PAF to PersAF after catheter ablation is associated with a larger LA diameter, history of thyroid disease, and the presence of non‐PV triggers. Meticulous preprocedural evaluation, patient selection, and comprehensive provocation tests during catheter ablation are recommended.
Genotype specific and microbiome effects of hypoxia in the model organism Daphnia magna
Authors: Coone Manon , Bisschop Karen , Vanoverberghe Isabel , Verslype Chris , Decaestecker Ellen 
Published: October 2023

Abstract
The fitness of the host is highly influenced by the interplay between the host and its associated microbiota. The flexible nature of these microbiota enables them to respond swiftly to shifts in the environment, which plays a key role in the host's capacity to withstand environmental stresses. To understand the role of the microbiome in host tolerance to hypoxia, one of the most significant chemical changes occurring in water ecosystems due to climate change, we performed a reciprocal gut transplant experiment with the freshwater crustacean Daphnia magna. In a microbiome transplant experiment, two genotypes of germ-free recipients were inoculated with gut microbiota from Daphnia donors of their own genotype or from the other genotype, that had been either pre-exposed to normoxic or hypoxic conditions. We found that D. magna individuals had a higher survival probability in hypoxia if their microbiome had been pre-exposed to hypoxia. The bacterial communities of the recipients changed over time with a reduction in alpha diversity, which was stronger when donors were pre-exposed to a hypoxic environment. While donor genotype had no influence on the long-term survival probability in hypoxia, donor genotypes was the most influential factor of the microbial community 3 days after the transplantation. Our results indicate that microbiome influencing factors mediate host fitness in a hypoxic environment in a time depending way.
Abstract
The fitness of the host is highly influenced by the interplay between the host and its associated microbiota. The flexible nature of these microbiota enables them to respond quickly to shifts in the environment, which plays a key role in the host's capacity to withstand environmental stresses. To understand the role of the microbiome in host tolerance to hypoxia, one of the most significant chemical changes occurring in water ecosystems due to climate change, we performed a reciprocal gut microbiome transplant experiment with the fresh water crustacean Daphnia magna. Two genotypes of germ-free recipients were inoculated with gut microbiota from Daphnia donors of their own genotype or from the other genotype, that had been either pre-exposed to normoxic or hypoxic conditions. We found that Daphnia magna individuals had a higher survival probability in hypoxia if their microbiome had been pre-exposed to hypoxia, moreover the bacterial communities of the recipients changed over time indicating that the microbiome mediates host fitness in a hypoxic environment in a time depending way.
Disclosure of strategic collaborative agreements and the cost of equity capital
Authors: Du Ya‐Guang , He Ying , Guo Meng‐Nan 
Published: October 2023

AbstractHow corporate strategic disclosure affects investor evaluations is a crucial and widely discussed question. Although prior literature has spent efforts analyzing the information effect of strategic alliances on investor reactions, whether this effect can extend to the cost of equity capital still needs to be explored. Using data from China's A‐share listed firms from 2007 to 2021, we examine the impact of disclosing strategic collaborative agreements on equity capital costs. We find that disclosing strategic collaborative agreements relates to lower equity capital costs. These results hold after several robustness checks. The mechanism test reveals that announcing strategic collaborative agreements alleviates equity capital costs mainly through the information effect. Moreover, this effect is more salient in firms with lower agency costs, lower media coverage, positive media sentiment, and higher media quality. These findings suggest that strategic collaborative agreements provide investors with valuable information.
“I'm fighting with BPD instead of my partner”: A dyadic interpretative phenomenological analysis of the lived experience of couples navigating borderline personality disorder
Authors: O'Leary Abigail M. , Landers Ashley L. , Jackson Jeffrey B. 
Published: October 2023

AbstractBorderline personality disorder (BPD) is associated with romantic relationship distress and dissolution. The complex interaction between BPD and romantic relationships warrants further attention. Dyadic interviews (N = 10) were conducted to examine the experience and impact of BPD on couples' relationships. The results of interpretative phenomenological analysis consisted of two superordinate themes describing the couple experience of navigating BPD: (a) the shared experience of BPD as a relational stressor; and (b) adaptive dyadic coping in the context of BPD. Although BPD was experienced as a relational stressor, dyadic coping and shared externalization of BPD emerged as central components to adaptive couple functioning. Most couples reported that therapy was a critical external resource in their journey toward adaptively functioning in the context of BPD, both intrapersonally and interpersonally. The lived experiences of these couples provides therapists with an increased understanding of the resources that support adaptive dyadic coping with BPD.
Making sense of linguistic diversity in Helsinki, Finland: The timespace of affects in the linguistic landscape
Authors: Pienimäki Hanna‐Mari , Väisänen Tuomas , Hiippala Tuomo 
Published: October 2023

AbstractThis article explores the spatiotemporal and affective qualities of linguistic landscapes at three linguistically diverse neighborhoods in Helsinki, Finland. The three sites were selected for qualitative fieldwork using a method that combines social media and population registry data with quantitative measures of diversity and spatial analytics. The article demonstrates how each site is characterized by its own distinct affective atmosphere, which is discursively construed and made sense of through references to other places and times. The timespace analysis of affects provides conceptual and methodological tools that allow analyzing the change and circulation of social meanings in the landscape, as well as differences in these aspects across settings.
The nanovirus U2 protein suppresses RNA silencing via three conserved cysteine residues
Authors: Yan Dankan , Han Kelei , Lu Yuwen , Peng Jiejun , Rao Shaofei , Wu Guanwei , Liu Yong , Chen Jianping , Zheng Hongying , Yan Fei 
Published: October 2023

AbstractNanoviruses have multipartite, circular, single‐stranded DNA genomes and cause huge production losses in legumes and other crops. No viral suppressor of RNA silencing (VSR) has yet been reported from a member of the genus Nanovirus. Here, we demonstrate that the nanovirus U2 protein is a VSR. The U2 protein of milk vetch dwarf virus (MDV) suppressed the silencing of the green fluorescent protein (GFP) gene induced by single‐stranded and double‐stranded RNA, and the systemic spread of the GFP silencing signal. An electrophoretic mobility shift assay showed that the U2 protein was able to bind double‐stranded 21‐nucleotide small interfering RNA (siRNA). The cysteine residues at positions 43, 79 and 82 in the MDV U2 protein are critical to its nuclear localization, self‐interaction and siRNA‐binding ability, and were essential for its VSR activity. In addition, expression of the U2 protein via a potato virus X vector induced more severe necrosis symptoms in Nicotiana benthamiana leaves. The U2 proteins of other nanoviruses also acted as VSRs, and the three conserved cysteine residues were indispensable for their VSR activity.
Treatment of Distal Third Humeral Shaft Fracture with Intramedullary Nail Combined with Anterior Minimally Invasive Plate Osteosynthesis
Authors: Fu Gang , Zhang Yichong , Ke Shuyujiong , Zhu Dengke , Wu Jingxiang , Su Dengbang , Ge Hui , Chen Jianlong , MB Yan Zhang , Lin Fengfei , Chen Jianhai , Li Renbin 
Published: October 2023

ObjectiveThe treatment of distal third humeral shaft fracture is difficult. Studies have shown that anterior minimally invasive plate has lower probability of complication and higher healing rate. However there is no applicable anatomical plate at present. This study is to investigate the clinical effect of intramedullary nail combined with anterior minimally invasive plate in the treatment of distal humeral shaft fractures.MethodsThe data of 83 patients with lower humerus shaft fracture treated from September 2015 to January 2020 were analyzed. According to different treatment methods, they were divided into two groups: 40 patients were treated with intramedullary nailing combined with minimally invasive anterior plate fixation (group A), and 43 patients were treated with double plate fixation through posterior approach (group B). General preoperative data, operative time, intraoperative blood loss, total incision length, fracture healing time, shoulder and elbow visual analogue scale (VAS) score, Constant–Murley shoulder function score, Mayo elbow function score, and complications were recorded and compared between the two groups. Two independent sample t‐tests was used for follow‐up, age, BMI, operation time, intraoperative bleeding, total incision length, fracture healing time, Constant–Murley score and Mayo score, and rank sum test was used for VAS score of shoulder and elbow.ResultsThere was no significant difference in preoperative general data between the two groups (p > 0.05), indicating comparability. There were no significant differences in operation time, total incision length, fracture healing time, Constant–Murley shoulder function score at the last follow‐up, Mayo elbow function score, and shoulder and elbow VAS pain score between 2 groups (p > 0.05). The amount of intraoperative blood loss in observation group was 76.98 ± 16.46, which was significantly less than that in control group, and the difference was statistically significant (p < 0.01). There were no radial nerve injury, musculocutaneous nerve injury, incision infection and fracture nonunion in the observation group. In the control group, four cases of iatrogenic radial nerve injury, three cases of incision infection and three cases of fracture nonunion were found. The complication rate was 23.3% (10/43). There was statistical difference in the incidence of complications between the two groups (p < 0.01).ConclusionA humeral intramedullary nail combined with an anterior minimally invasive plate in the treatment of distal humeral shaft fracture has the advantages of less soft tissue damage, less blood transfusion, high fracture healing rate and low risk of iatrogenic radial nerve injury, which is an effective method for clinical treatment of this type of fracture.
Analysis of Risk Factors for in‐hospital Death in Elderly Patients with TEXAS Stage 3 and 4 Diabetic Foot Ulcers after Tibial Transverse Translation: A Case–Control Study
Authors: Ding Xiaofang , Yuan Yusong , Xu Hailin , Jing Zhengwei , Lu Hao , Wang Yuanli , Zhou Junlin 
Published: October 2023

ObjectiveChinese physicians developed the Tibial Transverse Transport (TTT) technique to treat diabetic foot ulcers with more than 90% effective rate. But this method still could not avoid the in‐hospital death of patients. This study adopted a case‐control study to explore the risk factors of in‐hospital death in elderly patients with chronic ischemic diabetic foot after receiving TTT treatment.MethodsA total of 54 patients were included in the study from January 1, 2017 to April 30, 2021, by being paired with the cases in case group with their demographic data and results of blood routine, liver and kidney function. There were nine patients in case group with six male and three male. Forty‐five patients were selected in control group according to gender and diabetes type with 30 male and 15 female. Single factor logics regression analysis was used to explore the risk factors and odd ratios (OR) of in‐hospital death in patients. The nomogram and decision curve analysis (DCA) had been done by R Studio software.ResultsThe study found that age, course of diabetic foot, small dense low‐density Lipoprotein (smLDL), homocysteine (Hcy), superoxide dismutase (SOD), and prealbumin (PA) were risk factors for in‐hospital death of patients. The smLDL had the highest risk. The nomogram showed that PA accounted for the largest proportion in the death risk factors. The results of DCA proved that above six risk factors were the risk factors for patients with TEXAS Stage 3 and 4 diabetic foot ulcers.ConclusionIn the future diagnosis and TTT treatment for diabetic foot ulcers, doctors need to pay close attention to age, course of diabetic foot, smLDL, Hcy, SOD, and PA.
Three decades of collaboration through the Pediatric Heart Transplant Society Registry: A journey through registry data with a highlight on children with single ventricle anatomy
Authors: Richmond Marc E. , Conway Jennifer , Kirklin James K. , Cantor Ryan S. , Koehl Devin A. , Lal Ashwin K. , McDonald Nancy , Gajarski Robert , Lin Kimberly Y. , Singh Rakesh K. , Fenton Matthew , Asante‐Korang Alfred , Amdani Shahnawaz , Auerbach Scott R. , Everitt Melanie D. 
Published: October 2023

AbstractBackgroundThe Pediatric Heart Transplant Society (PHTS) Registry was founded 30 years ago as a collaborative effort among like‐minded providers of this novel life‐saving technique for children with end‐stage heart failure. In the intervening decades, the data from the Registry have provided invaluable knowledge to the field of pediatric heart transplantation. This report of the PHTS Registry provides a comprehensive look at the data, highlighting both the longevity of the registry and one unique aspect of the PHTS registry, allowing for exploration into children with single ventricle anatomy.MethodsThe PHTS database was queried from January 1, 1993 to December 31, 2019 to include pediatric (age < 18 years) patients listed for HT. For our analysis, we primarily analyzed patients by era. The early era was defined as children listed for HT from January 1, 1993 to December 31, 2004; middle era January 1, 2005 to December 31, 2009; and recent era January 1, 2010 to December 31, 2019. Outcomes after listing and transplant, including mortality and morbidities, are presented as unadjusted for risk, but compared across eras.ResultsSince 1993, 11 995 children were listed for heart transplant and entered into the PHTS Registry with 9755 listed during the study period. The majority of listings occurred within the most recent era. Waitlist survival improved over the decades as did posttransplant survival. Other notable changes over time include fewer patients experiencing allograft rejection or infection after transplant. Waitlist and posttransplant survival have changed dramatically in patients with single ventricle physiology and significantly differ by stage of single ventricle palliation.SummaryKey points from this PHTS Registry summary and focus on patients with single ventricle congenital heart disease in particular, include the changing landscape of candidates and recipients awaiting heart transplant. There is clear improvement in waitlist and transplant outcomes for children with both cardiomyopathy and congenital heart disease alike.
(In defence of) preservationism and the previous awareness condition: What is a theory of remembering, anyway?
Authors: Openshaw James 
Published: October 2023

AbstractI suggest that the theories of remembering one finds in the philosophy of memory literature are best characterised as theories principally operating at three different levels of inquiry. Simulationist views are theories of the psychofunctional process type remembering. Causalist views are theories of referential remembering. Epistemic views are theories of successful remembering. Insofar as there is conflict between these theories, it is a conflict of integration rather than—as widely presented—head‐on disagreement. Viewed in this way, we can see the previous awareness condition and preservationism as principles applying at only some of the corresponding levels of inquiry. Where either principle has been rejected, it is, I claim, due to arguments which slip between these different levels. While the view of the landscape I offer does not dissolve ongoing disputes about the nature of remembering, it clarifies the dialectical rules of engagement, helping to clear the path for future, collaborative progress to be made. The view enables us to see less conflict in the recent philosophy of memory literature than there seems at face value to be.
Risk factors for mortality in infancy and childhood in children with major congenital anomalies: A European population‐based cohort study
Authors: Tan Joachim , Glinianaia Svetlana V. , Rankin Judith , Pierini Anna , Santoro Michele , Coi Alessio , Garne Ester , Loane Maria , Given Joanne E. , Brigden Joanna , Ballardini Elisa , Cavero‐Carbonell Clara , de Walle Hermien E. K. , García‐Villodre Laura , Gatt Miriam , Gissler Mika , Heino Anna , Jordan Sue , Khoshnood Babak , Klungsoyr Kari , Lelong Nathalie , Lutke Renée L. , Neville Amanda J. , Tucker David , Urhoj Stine K. , Wellesley Diana , Morris Joan K. 
Published: October 2023

AbstractBackgroundPreterm birth and young maternal age are known risk factors for infant and childhood mortality. There is limited knowledge of the impact of these risk factors in children born with major congenital anomalies (CAs), who have inherently higher risks of death compared with other children.ObjectivesTo investigate the risk factors for mortality up to age 10 years in children born with specific major CAs.MethodsThis population‐based cohort study involved 150,198 livebirths from 1995 to 2014 in 13 European CA registries linked to mortality data. Cox proportional hazards models estimated the association of gestational age, maternal age and child's sex with death <1 year and 1–9 years for the whole cohort and by CA subgroup. Hazard ratios (HR) from each registry were pooled using multivariate meta‐analysis.ResultsPreterm birth had a dose–response association with mortality; compared with infants born at 37+ weeks gestation, those born at <28, 28–31 and 32–36 weeks had 14.88 (95% CI 12.57, 17.62), 8.39 (95% CI 7.16, 9.85) and 3.88 (95% CI 3.40, 4.43) times higher risk of death <1 year, respectively. The corresponding risks at 1–9 years were 4.99 (95% CI 2.94, 8.48), 3.09 (95% CI 2.28, 4.18) and 2.04 (95% CI 1.69, 2.46) times higher, respectively. Maternal age <20 years (versus 20–34 years) was a risk factor for death <1 year (HR 1.30, 95% CI 1.09, 1.54) and 1–9 years (HR 1.58, 95% CI 1.19, 2.10). Females had 1.22 (95% CI 1.07, 1.39) times higher risk of death between 1 and 9 years than males.ConclusionPreterm birth was associated with considerably higher infant and childhood mortality in children with CAs, comparable to estimates reported elsewhere for the background population. Additional risk factors included young maternal age and female sex. Information on risk factors could benefit clinical care and guide counselling of parents following CA diagnoses.
Detection of major congenital malformations depends on length of follow‐up in Swedish National Health Register Data: Implications for pharmacoepidemiological research on medication safety in pregnancy
Authors: Segovia Chacón Silvia , Karlsson Pär , Cesta Carolyn E. 
Published: October 2023

AbstractBackgroundIn observational medication pregnancy safety studies, children are often followed from birth to 1 year of age. However, some major congenital malformations (MCM) may take longer to diagnose.ObjectivesWe aimed to investigate the proportion of children with detected MCMs at different lengths of follow‐up and compare them to the proportion detected at 1 year after birth.MethodsThis population‐based register study included all singleton children liveborn in Sweden from 2006 to 2016. MCM were identified by ICD‐10 codes in the Medical Birth Register and National Patient Register, aligned to the EUROCAT classification system. Cumulative proportion of children with detected MCM at birth, 90 days, 1, 2, and 3 years was calculated and compared between children born preterm and at term.ResultsIn 1,138,113 liveborn children, the cumulative proportion of children with a detected MCM increased from 1.9% at birth to 3.1%, 3.9%, 4.4% and 4.7% at 90 days, 1, 2, and 3 years after birth, respectively, and varied by MCM subgroup. MCMs of the eye, ear‐face‐neck, nervous system and genitals were detected with the longest delay, with 31%–59% more detected at 3‐ versus 1‐year follow‐up. Compared to children born at term, the proportion of children with any MCM was 2.5 times higher amongst preterm children, with a higher proportion detected over the first 90 days for most MCM subgroups.ConclusionsThe proportion of children with a detected MCM varied by MCM subgroup and follow‐up time. In pharmacoepidemiology studies of medication safety in pregnancy using Swedish national data, the length of child follow‐up should be chosen in accordance with the expected age at detection if a specific subgroup of MCM is under investigation, for example, eye and genital MCM require longer follow‐up for detection than abdominal wall and digestive system MCM. However, in most circumstances, 1 year of follow‐up is sufficient.