bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variability drives differences in the structure of the calanoid copepod community in two contrasting regions of the Gulf of Mexico
Authors: Gaona-Hernández Aurora , Suárez-Morales Eduardo , Linacre Lorena , Compaire Jesus C , Lara-Lara J Rubén , Herzka Sharon Z 
Published: January 2024

Abstract
Calanoid copepods (CC) are key contributors to the biological carbon pump and pelagic trophic dynamics. The deep-water regions of Perdido and the Bay of Campeche in the western and southern Gulf of Mexico (GM), respectively, differ in hydrography and productivity, leading to potential differences in copepod biomass and community structure. Zooplankton (0-200 m) were collected from the shelf edge to the deep-water region during the winter and summer autumn 2016. Calanoids contributed 38-60% of total zooplankton biomass and 55-70% of overall copepod abundance. The Bay of Campeche had the highest total zooplankton biovolume (287±120 ml 1000 m−3) and total mean copepod abundance (CC and non-calanoids ~146,000 ind. 1000 m−3) during summer-autumn, likely resulting from cross-shelf nutrient transport fueling local productivity. Adult females dominated calanoid numerical abundance (43-50%), thus suggesting a high reproductive potential. Cluster analysis showed differences between seasons (~40% dissimilarity) but not regions. Environmental conditions explained 22% of the variability in community composition; the winter assemblage was significantly related to oxygen concentrations, whereas the summer-autumn community was related to warmer conditions and higher integrated chlorophyll-a concentrations. The CC community responded to seasonal changes more than regionally related hydrographic differences, with likely implications for organic matter cycling and export.
Rice LIKE EARLY STARVATION1 cooperates with FLOURY ENDOSPERM6 to modulate starch biosynthesis and endosperm development
Authors: Yan Haigang , Zhang Wenwei , Wang Yihua , Jin Jie , Xu Hancong , Fu Yushuang , Shan Zhuangzhuang , Wang Xin , Teng Xuan , Li Xin , Wang Yongxiang , Hu Xiaoqing , Zhang Wenxiang , Zhu Changyuan , Zhang Xiao , Zhang Yu , Wang Rongqi , Zhang Jie , Cai Yue , You Xiaoman , Chen Jie , Ge Xinyuan , Wang Liang , Xu Jiahuan , Jiang Ling , Liu Shijia , Lei Cailin , Zhang Xin , Wang Haiyang , Ren Yulong , Wan Jianmin 
Published: January 2024

Abstract
In cereal grains, starch is synthesized by the concerted actions of multiple enzymes on the surface of starch granules within the amyloplast. However, little is known about how starch-synthesizing enzymes access starch granules, especially for amylopectin biosynthesis. Here, we show that the rice (Oryza sativa) floury endosperm9 (flo9) mutant is defective in amylopectin biosynthesis, leading to grains exhibiting a floury endosperm with a hollow core. Molecular cloning revealed that FLO9 encodes a plant-specific protein homologous to Arabidopsis (Arabidopsis thaliana) LIKE EARLY STARVATION1 (LESV). Unlike Arabidopsis LESV, which is involved in starch metabolism in leaves, OsLESV is required for starch granule initiation in the endosperm. OsLESV can directly bind to starch by its C-terminal tryptophan (Trp)-rich region. Cellular and biochemical evidence suggests that OsLESV interacts with the starch-binding protein FLO6, and loss-of-function mutations of either gene impair ISOAMYLASE1 (ISA1) targeting to starch granules. Genetically, OsLESV acts synergistically with FLO6 to regulate starch biosynthesis and endosperm development. Together, our results identify OsLESV-FLO6 as a non-enzymatic molecular module responsible for ISA1 localization on starch granules, and present a target gene for use in biotechnology to control starch content and composition in rice endosperm.
Uncertainty quantification in computed tomography pulmonary angiography
Authors: Rambojun Adwaye M , Komber Hend , Rossdale Jennifer , Suntharalingam Jay , Rodrigues Jonathan C L , Ehrhardt Matthias J , Repetti Audrey 
Published: January 2024

Abstract
Computed tomography (CT) imaging of the thorax is widely used for the detection and monitoring of pulmonary embolism (PE). However, CT images can contain artifacts due to the acquisition or the processes involved in image reconstruction. Radiologists often have to distinguish between such artifacts and actual PEs. We provide a proof of concept in the form of a scalable hypothesis testing method for CT, to enable quantifying uncertainty of possible PEs. In particular, we introduce a Bayesian Framework to quantify the uncertainty of an observed compact structure that can be identified as a PE. We assess the ability of the method to operate under high-noise environments and with insufficient data.
Control of Frustrated Nonsequential Double Ionization Channels With the Carrier-Envelope Phase of Elliptically Polarized Laser Pulses
Authors: Xu Tong-Tong , Zhang Lian-Lian , Gong Wei-Jiang 
Published: January 2024

Abstract
Using a classical approach, we theoretically investigate the frustrated double ionization (FDI) of Ar atoms under elliptically polarized (EP) laser fields. The FDI yield is calculated as a function of laser intensity with different carrier-envelope phases (CEPs), and, similar to the carrier-envelope phase (CEP) dependence of nonsequential double ionization (NSDI), several knee-shaped structures appear. Moreover, both recollision and direct ionization trajectories are observed in FDI events for the “knee” structure regime. The footprints of which channel leads to FDI are encoded in the photoelectron momentum distributions. FDI events related to recollision excitation with subsequent ionization channels and recollision impact ionization channels can be controlled by CEP in EP laser fields.
Beyond pGALS: the need for a multifaceted musculoskeletal decision-making tool (‘pGALSplus’) in community-based clinical practice
Authors: Mercer Vicky , Smith Nicola , Jandial Sharmila , Guglieri Michela , Jones Simon A , Foster Helen E 
Published: January 2024

Abstract
Musculoskeletal (MSK) problems in children are common, and health-care professionals must identify those requiring onward referral. Paediatric gait, arms, legs and spine (pGALS) is an MSK assessment to discern abnormal joints. We aimed to identify MSK assessments to add to pGALS (pGALSplus) to facilitate decision-making in the context of exemplar conditions representing a spectrum of MSK presentations, namely JIA, mucopolysaccharidoses, muscular dystrophy and developmental co-ordination disorder. A literature review identified 35 relevant articles that focused on clinical assessments [including questionnaire(s), physical examination and functional tests] used by health-care professionals in the context of the exemplar conditions. We provide a description of these assessments and the rationale regarding how they, or components of such tools, might be useful within pGALSplus. This process provides a foundation for further work to develop and validate pGALSplus.
Trend Factor in China: The Role of Large Individual Trading
Authors: Liu Yang , Zhou Guofu , Zhu Yingzi 
Published: January 2024

Abstract
We propose a novel trend factor for the Chinese stock market that incorporates both price and volume information to capture dominant individual trading, momentum, and liquidity. We find that volume plays a more significant role in the trend factor for China than for the United States, reflecting the greater retail participation in China. By incorporating this trend factor into the 3-factor model of Liu et al. (2019), we propose a 4-factor model that explains a wide range of stylized facts and 60 representative anomalies. Our study highlights the important role of individual trading in asset pricing, especially in China. (JEL G12, G14, G15)
The association between timing of dietary macronutrient and sodium consumption and sleep duration and quality
Authors: Baidoo Velarie Yaa Ansu , Alexandria Shaina J , Zee Phyllis C , Knutson Kristen L 
Published: January 2024

Abstract

Study Objective
The objective of this study was to examine the association between the timing of dietary macronutrients and sodium intake and sleep quantity and quality.

Methods
This was a cross-sectional study that included 34 adults between 21 and 50 years of age. The main outcome measures were objective sleep measures assessed from three nights of wrist actigraphy including sleep duration, fragmentation, and wake after sleep onset (WASO), and one night of polysomnography (PSG), including rapid eye movement (REM) sleep, non-REM stage 2 (N2), stage 3 (N3), and WASO. Multiple linear regression models and linear mixed models were used to estimate the associations between sleep measures and dietary measures (carbohydrates, fats, saturated fats, proteins, and sodium). Dietary timing was examined in two ways: (1) the average amount of each nutrient consumed within 3 hours of sleep start, and (2) the interval between the final intake of each nutrient and sleep.

Results
Average fat intake within 3 hours of sleep was associated with greater WASO from PSG (β = 4.48, p = 0.01). No other associations were found between the macronutrients or sodium intake (p &gt; 0.05) within 3 hours of sleep and the sleep parameters from PSG or actigraphy. Similarly, no associations were found between any of the PSG or actigraphy sleep measures and the interval between final nutrient intakes and sleep with sleep duration.

Conclusions
The study suggests that greater fat but not carbohydrate, protein, saturated fat, or sodium intake close to sleep may be associated with greater sleep disruption; however, no other associations were observed.
Somatization Mediates the Relationship Between Childhood Trauma and Pain Ratings in Patients with Irritable Bowel Syndrome
Authors: Schubach Abigail , Quigley Brian M. , Lackner Jeffrey M. , Gudleski Gregory D. 
Published: January 2024

Goals:
To identify potential mechanisms by which childhood trauma may lead to the adult development of abdominal symptoms in patients with irritable bowel syndrome (IBS).

Background:
Patients with IBS frequently report a history of childhood trauma. The pathophysiology by which abdominal pain arises in patients with IBS is multidimensional, consisting of both peripheral factors, such as altered motility, inflammation, and bacterial overgrowth, as well as central factors, such as psychological distress and neuro-hormonal dysregulation.

Study:
Adult psychological factors (anxiety, depression, and somatization) were examined to determine if they mediate the relationship between retrospective reports of childhood trauma and current adult IBS abdominal symptoms in a study of 436 patients (M age=41.6, 79% F) meeting Rome III diagnosis criteria. Childhood trauma was measured using retrospective questions assessing physical and sexual abuse. Psychological factors in adulthood were measured with the subscales of the Brief Symptom Inventory-18. Outcome variables included adult IBS symptoms of abdominal pain, bloating, and satisfaction with bowel habits from the IBS Symptoms Severity Scale.

Results:
Results indicated that somatization mediated the relationship between childhood abuse and abdominal pain and bloating but not bowel satisfaction.

Conclusions:
This study provides insight into the multifactorial nature of IBS-associated abdominal pain in patients with a history of childhood trauma, elucidating the need for a trauma-informed treatment approach for patients with histories of abuse.
PHACE syndrome: a case report and a comprehensive review
Authors: William Munna , Bhusal Amrit , Umar Syed Muhammad , Jamal Ayesha , Anjum Abdul Sattar , Habib Mudasira 
Published: January 2024

Introduction and importance:
PHACE syndrome is a rare neurocutaneous disorder characterized by large segmental hemangiomas on the face and is associated with multiple developmental defects. PHACE stands for posterior fossa malformations, hemangiomas, arterial abnormalities, cardiac defects, and eye anomalies, with the most common manifestation being hemangioma in the cervico-facial region in early childhood.

Case presentation:
The authors report a case of a 15-year-female with complaints of facial hemangioma which on multisystemic imaging showed features of central nervous system (CNS) anomalies that led to the diagnosis of PHACE syndrome. The patient was started on propanolol which decreased the size of hemangioma in follow-up visits.

Clinical discussion:
The hemangioma in the frontotemporal and frontonasal area of the face are associated more with CNS and cardiovascular anomalies needing a detailed multisystem approach. CNS anomalies include posterior cerebral fossa enlargement, cystic dilation of the fourth ventricle, arachnoid cyst, and cerebellar hypoplasia which were present in our case. Propanolol is considered the first-line drug for facial hemangioma with reported evidence of remarkable improvement and good tolerance. However, regular follow-up of the patient is needed to rule out any recurrence.

Conclusion:
PHACE syndrome, although being a rare occurrence, must be kept as a differential diagnosis in infants and children with facial hemangioma. Imaging modalities like MRI/magnetic resonance arteriography must be used to rule out possible associations related to PHACE syndrome and focus on early treatment to prevent possible complications.
Telemedicine and Cancer Care
Authors: Doshi Sahil D. , Bange Erin M. , Daly Bobby , Kuperman Gilad , Panageas Katherine S. , Morris Michael J. 
Published: January 2024

Abstract
Telemedicine holds the potential to transform cancer care delivery and optimize value, access, and quality of care. A transformed regulatory environment coupled with the need to continue medical care despite operational limitations led to the rapid expansion of telemedicine in cancer care during the COVID-19 pandemic. Its utilization has since varied, and it has faced significant challenges. In this review, we will explore the state of telemedicine in cancer care delivery, the challenges it faces, and strategies to enhance its successful implementation.
Supportive Care for Cancer Patients Via Telehealth
Authors: Soumerai Tara E. , Mulvey Therese M. , Jackson Vicki A. , Lennes Inga T. 
Published: January 2024

AbstractDelivering oncologic care via telemedicine has presented a unique set of benefits and challenges. Discussions of sensitive topics between patients and providers can be difficult on a virtual platform. Although it was imperative to utilize telemedicine to keep cancer patients safe during the height of the pandemic, its continued use in the postvaccination era has provided important conveniences to both providers and patients. In the case of breaking bad news and end-of-life discussions, however, in-person care has remained the overwhelming preference of both groups. If face-to-face consultation is not possible or feasible in these situations, virtual visits are a viable option to connect oncologists with their patients.
Distinguishing fibromyalgia syndrome from small fiber neuropathy: a clinical guide
Authors: Jänsch Sarah , Evdokimov Dimitar , Egenolf Nadine , Meyer zu Altenschildesche Caren , Kreß Luisa , Üçeyler Nurcan 
Published: January 2024

Abstract

Introduction:
Fibromyalgia syndrome (FMS) and small fiber neuropathy (SFN) are distinct pain conditions that share commonalities and may be challenging as for differential diagnosis.

Objective:
To comprehensively investigate clinical characteristics of women with FMS and SFN to determine clinically applicable parameters for differentiation.

Methods:
We retrospectively analyzed medical records of 158 women with FMS and 53 with SFN focusing on pain-specific medical and family history, accompanying symptoms, additional diseases, and treatment. We investigated data obtained using standardized pain, depression, and anxiety questionnaires. We further analyzed test results and findings obtained in standardized small fiber tests.

Results:
FMS patients were on average ten years younger at symptom onset, described higher pain intensities requiring frequent change of pharmaceutics, and reported generalized pain compared to SFN. Pain in FMS was accompanied by irritable bowel or sleep disturbances, and in SFN by paresthesias, numbness, and impaired glucose metabolism (P < 0.01 each). Family history was informative for chronic pain and affective disorders in FMS (P < 0.001) and for neurological disorders in SFN patients (P < 0.001). Small fiber pathology in terms of skin denervation and/or thermal sensory threshold elevation was present in 110/158 (69.7 %) FMS patients and 39/53 (73.6 %) SFN patients. FMS patients mainly showed proximally reduced skin innervation and higher corneal nerve branch densities (p<0.001) whereas SFN patients were characterized by reduced cold detection and prolonged electrical A-delta conduction latencies (P < 0.05).

Conclusions:
Our data show that FMS and SFN differ substantially. Detailed pain, drug and family history, investigating blood glucose metabolism, and applying differential small fiber tests may help to improve diagnostic differentiation and targeted therapy.
Vanderbilt Mini-PROM–Breast for Breast Reconstruction: A Short-Form, Patient-Reported Outcomes Measure
Authors: Park Benjamin C. , Drolet Brian C. , Perdikis Galen 
Published: January 2024

Background:
Breast reconstruction procedures are among the most commonly performed plastic surgery operations. Although there are well-validated patient-reported outcomes measures (PROMs) for breast reconstruction, there are several patient-, provider-, and service-level barriers to their implementation in routine clinical settings. Therefore, we developed a short-form PROM to evaluate breast reconstruction outcomes.

Methods:
Using a mixed-methods approach, the Vanderbilt Mini-PROM–Breast (VMP-B) was constructed and validated to assess patient-reported outcomes from breast reconstruction. Classic test theory methods were used to evaluate acceptability, reliability, and validity. External validation was subsequently performed using the BREAST-Q as a reference standard.

Results:
The VMP-B is a 16-item instrument composed of three domains: quality of life, body image, and breast satisfaction. Psychometric properties including acceptability, reliability, and validity exceeded reference criteria. When tested with 104 patients, the authors found significant benefits of breast reconstruction on quality of life, body image, and breast satisfaction. These results were associated with sizeable effect sizes (g) (g = 0.421, g = 0.520, and g = 1.25) demonstrative of clinically meaningful results. When tested concurrently in 70 patients, the VMP-B and the BREAST-Q showed similar results, exhibiting excellent convergent validity.

Conclusions:
The VMP-B is a validated short-form PROM that reliably assesses breast reconstruction outcomes. As a short form, the VMP-B decreases both patient and provider burden, which allows for routine, point-of-care collection of breast reconstruction outcomes.
Novel Noninvasive Hybrid Flap Preconditioning Surpasses Surgical Delay in the Murine Model
Authors: Du Xingyi , Liu Wenyue , Xu Boyang , Luan Jie , Liu Chunjun 
Published: January 2024

Background:
Ischemic necrosis in the distal portion of a flap is a challenging complication in plastic surgery. The authors hypothesized that a novel hybrid flap preconditioning (HFP) device combining foam-mediated external suction and nonsurgical delay can promote skin flap survival better than surgical delay.

Method:
Twenty-eight mice were divided into 4 groups: a control group, in which a 4 × 1.5–cm dorsal flap was made with no preconditioning; a surgical delay group, in which surgical delay occurred 7 days before flap elevation; a foam-mediated external suction (FMES) group, in which foam-mediated external suction at −100 mm Hg was used 5 hours a day for 6 days, and the flap was elevated on the seventh day; and a hybrid flap preconditioning (HFP) group, in which silicone strips were applied along the contour of the foam interface. The same negative-pressure protocol was used as in the FMES group. Seven days after flap elevation, macroscopic, histologic, and Western blot analyses were performed.

Results:
The flap survival rate was 46.25% (8.12%) in the control group, 68.72% (7.00%) in the surgical delay group, 57.03% (8.17%) in the FMES group, and 80.66% (3.27%) in the HFP group. Immunohistologic analysis of CD31+ cells in the distal end of viable tissue procured 7 days after flap elevation showed significantly higher angiogenesis in the surgical delay and HFP groups. Western blot results showed an increased expression of vascular endothelial growth factor in the surgical delay and HFP groups.

Conclusions:
The authors developed and fabricated a novel HFP device combining foam-mediated external suction and nonsurgical delay. The concept of HFP has proved to promote flap survival better than surgical delay.

Clinical Relevance Statement:
This study presented an innovative noninvasive method of flap preconditioning, which has been demonstrated to be superior to surgical delay in a murine model and holds promise for potential application in clinical settings.
Low Strip Unifying Hybrid Rhinoseptoplasty: A Novel Classification in Dorsal Preservation Surgery
Authors: Taglialatela Scafati Salvatore , Rasulo Mario , Göksel Abdülkadir 
Published: January 2024

Background:
Preservation rhinoplasty techniques continue to evolve. Suture tip-plasty with minimal resection and grafting, lateral crural tensioning, minimal excision from the lateral crura, dorsal preservation, subperichondrial dissection, and preservation of the ligaments have become the milestones of modern rhinosurgery. However, every time the dorsal frame is modified by means of rasping, shaving, or osteotomy, or the nasal tip is structured using grafts, surgeons are essentially applying structural concepts to their technique. The term “hybrid rhinoplasty” seems to include a more appropriate definition of this approach.

Methods:
The authors performed a retrospective analysis of the medical records of patients who underwent primary septorhinoplasty using the low strip unifying hybrid rhinoseptoplasty concept from December of 2019 to June of 2022. Patient functional satisfaction and cosmetic satisfaction were evaluated using the Rhinoplasty Health Inventory and Nose Outcome scale.

Results:
All reported procedures had low revision rates with good cosmetic and functional outcomes.

Conclusions:
Tailoring the surgical technique is essential in rhinoplasty. The authors present a new technical paradigm to help surgeons choose the best approach for dorsal preservation surgery.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.