bluuebunny/crossref_metadata_2025_split huggingface dataset:
The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes
Authors: Gilles Ambroise , Hu Lan , Virdis Francesca , Sant’Angelo Derek B , Dimitrova Nevenka , Hedrick Joseph A , Denzin Lisa K 
Published: October 2023

Abstract
Peptide loading of MHC class II (MHCII) molecules is facilitated by HLA-DM (DM), which catalyzes CLIP release, stabilizes empty MHCII, and edits the MHCII-bound peptide repertoire. HLA-DO (DO) binds to DM and modulates its activity, resulting in an altered set of peptides presented at the cell surface. MHCII–peptide presentation in individuals with type 1 diabetes (T1D) is abnormal, leading to a breakdown in tolerance; however, no direct measurement of the MHCII pathway activity in T1D patients has been performed. In this study, we measured MHCII Ag-processing pathway activity in humans by determining MHCII, MHCII–CLIP, DM, and DO levels by flow cytometry for peripheral blood B cells, dendritic cells, and monocytes from 99 T1D patients and 97 controls. Results showed that MHCII levels were similar for all three APC subsets. In contrast, MHCII–CLIP levels, independent of sex, age at blood draw, disease duration, and diagnosis age, were significantly increased for all three APCs, with B cells showing the largest increase (3.4-fold). DM and DO levels, which usually directly correlate with MHCII–CLIP levels, were unexpectedly identical in T1D patients and controls. Gene expression profiling on PBMC RNA showed that DMB mRNA was significantly elevated in T1D patients with residual C-peptide. This resulted in higher levels of DM protein in B cells and dendritic cells. DO levels were also increased, suggesting that the MHCII pathway maybe differentially regulated in individuals with residual C-peptide. Collectively, these studies show a dysregulation of the MHCII Ag-processing pathway in patients with T1D.
Temporal evolution of suspended solids in the management of medium-sized watersheds in the Metropolitan Region of Paraíba Valley
Authors: Ferreira Willian José , Targa Marcelo dos Santos , Catelani Celso de Souza 
Published: October 2023

The demand for water to meet the needs of the population has increased with the rapid growth of urban centers. The urban expansion in Taubaté (23.03º S, 45.55º W) negatively impacts the Una River Basin, a significant tributary of the Paraíba do Sul River, resulting in issues of sedimentation, siltation, and flooding. Systematic monitoring of sediment characteristics in human-influenced areas allows for an understanding of water quality variations, watershed diagnosis, and analysis of impacts on aquatic ecosystems, with total suspended solids (TSS) being a widely used parameter in this context. This study investigated the temporal evolution of the TSS concentration in the Una River, highlighting the importance of sound management practices to reduce sedimentation in urban catchments, through the analysis of biochemical parameters obtained from the Cetesb/Infoaguas platform. From 2008 to 2022, lower TSS concentrations were observed in winter (86.2 ± 35.6 mg L-1), while higher values were obtained in summer (779.7 ± 1024.8 mg L-1). In general, statistically significant correlations were found at the 95% confidence level between TSS and turbidity (Pearson's r = 0.93), dissolved oxygen (Pearson's r = -0.46), and electrical conductivity (Pearson's r = -0.43), while other evaluated parameters (pH, dissolved solids, and precipitation) did not show significant correlations. Among the key findings, it is crucial to study the temporal evolution of TSS and to implement sustainable management strategies in urban catchments, including erosion control measures and stormwater management, to preserve water quality, aquatic ecosystems, and water supply in the urban communities of RMVale.
Keywords: basin, management strategies, sustainable, total suspended solids.
Asymptotics for symmetrized positive moments of odd ranks
Authors: Liu Edward Y. S. 
Published: October 2023

AbstractIn 2007, Andrews introduced Durfee symbols and k-marked Durfee symbols so as to give a combinatorial interpretation for the symmetrized moment function
$\eta _{2k}(n)$
of ranks of partitions. He also considered the relations between odd Durfee symbols and the mock theta function
$\omega (q)$
, and proved that the
$2k$
th moment function
$\eta _{2k}^0(n)$
of odd ranks of odd Durfee symbols counts
$(k+1)$
-marked odd Durfee symbols of n. In this paper, we first introduce the definition of symmetrized positive odd rank moments
$\eta _k^{0+}(n)$
and prove that for all
$1\leq i\leq k+1$
,
$\eta _{2k-1}^{0+}(n)$
is equal to the number of
$(k+1)$
-marked odd Durfee symbols of n with the ith odd rank equal to zero and
$\eta _{2k}^{0+}(n)$
is equal to the number of
$(k+1)$
-marked Durfee symbols of n with the ith odd rank being positive. Then we calculate the generating functions of
$\eta _{k}^{0+}(n)$
and study its asymptotic behavior. Finally, we use Wright’s variant of the Hardy–Ramanujan circle method to obtain an asymptotic formula for
$\eta _{k}^{0+}(n)$
.
El hijo del hijo del jefe
Authors: Huamán Almirón Abraham 
Published: October 2023

A MANERA DE INTRODUCCIÓN
Abandoné la tierra de las uvas, de los vinos,
del buen pisco, y sobre todo de la Huacachina
—aquella laguna del desierto de Ica que fue testigo
de mi infancia, de mi adolescencia, de mis
grandes sueños—, que por un desafío amoroso
dejé, aquel lugar que no volvería a ver con los
ojos de antaño.
Eran días de ansiedad y de preocupación
pues el dinero no valía nada la moneda había
cambiado de la denominación “Sol” a llamarse
“Inti” y la gente hacía grandes “colas” para comprar
el pan, el arroz, el azúcar. En esos días aciagos
me encuentro con mi amigo Marko Polo, él
había estudiado pedagogía en Pucallpa, y por
cosas del destino salió de su tierra para encontrar
mejores horizontes de vida en estos lares
sureños. Al parecer la estadía le iba bien, pues
en poco tiempo hizo varias publicaciones de
cuentos infantiles y realizados grandes conciertos
en los principales cinemas de la ciudad, en
los que demostraba tener cualidad para el canto
en sus diversas presentaciones a la vez que com8
partía sus actividades artísticas con la docencia
en una escuela de la provincia de Pisco.
Pero había otros como yo, que no tenían
nada y en esa época el que menos migraba de
un lugar a otro, dentro o fuera de nuestro país,
para hacer suyo la frase bíblica: “Nadie es profeta
en su tierra”. Es así que llego a la Selva —por
insinuación de Marko Polo y a través de una
carta de recomendación para el poeta y escritor
amazónico Jorge Luis Salazar—, la selva de
la que tantas historias había escuchado y leído
de ella desde Sangama de Arturo Hernández a
Juana… ¿Virgen?, del que posteriormente sería
nuestro amigo y ahora ya difunto Arnaldo Panaifo
Teixeira, al fin la conocería y después sería
algo del que no podría alejarme hasta ahora,
porque siempre hay pretextos para no irme de
este sagrado lugar de las culturas y de los pueblos
indígenas amazónicos.
Así que allá, por los años noventa me encuentro
en el Ucayali en su lejana y fronteriza
provincia del Purús, en una comunidad nativa
del pueblo Sharanahua llamado Gastabala, que
en bote queda cinco días río arriba, ejerciendo
la docencia y experimentando el mundo enigmático
y fabuloso de su gente.
Perlindungan Hak Asasi Manusia Pekerja Migran Di Qatar Terhadap Sistem Kafala Berdasarkan Konvensi International Labour Organization Nomor 143 Tahun 1975 Tentang Pekerja Migran
Authors: Likumahua Azarya Gerry , Anwar Arman , Waas Richard Marsilio 
Published: October 2023

Introduction: Migrant workers have human rights that must be respected and protected.Purposes of the Research: This paper aims to find out and analyze the regulations on the protection of the human rights of migrant workers in terms of ILO Convention Number 143 of 1975 concerning migrant workers and to find out and analyze the kafala system in Qatar contrary to ILO Convention Number 143 of 1975 concerning migrant workers.Methods of the Research: The method used is a normative juridical research method using a case approach and a statutory approachResults of the Research: The results of the study show that the ILO Convention 143 of 1975 concerning Migrant Workers has guaranteed the respect and protection of the human rights of migrant workers, while the Kafala system is based on the Qatar Constitution which is based on Islamic sharia law where the legal relationship between the employer (insurer) and the worker (insured) must be mutually agreed upon. in the contract (agreement) in the principle of trust (sponsorship) imbued with the spirit of religiosity, but in practice its implementation has been misused by employers and companies for the benefit of their personal gain so that they are no longer trustworthy in carrying out their responsibilities as stipulated in the Kafalah system. The Kafala system needs to be reviewed and evaluated by the Government of Qatar so that in its application it is no longer misused. Meanwhile, the ILO needs to provide a firm response to the occurrence of human rights violations of migrant workers in Qatar so that they do not happen again in the future.
Perdagangan Satwa Liar Ditinjau Dari Convention On International Trade In Endangered Species Of Wild Fauna And Flaura
Authors: Ramadanti Nur Afya , Tahamata Lucia Charlota Octovina , Leatemia Wilshen 
Published: October 2023

Introduction: Smuggling, trading, and theft of protected wild animals have increased quite high, such as orangutans, tigers, primates, and various other types of wildlife. It was recorded that since 2014 there were 14 cases until in 2016 the cases increased to 25 cases of illegal wildlife trade. This will have an impact on the lack of heritage biodiversity for mankind.Purposes of the Research: To find out about protection against wildlife trade according to the Convention On International Trade In Endangered Species Of Wild Fauna And FlauraMethods of the Research: The research used is normative juridical research. The research approach uses a legal approach, a conceptual approach and a case approach. Sources of research data are primary, secondary, tertiary data which is carried out by searching for library materials, namely studies related to international and national laws and regulations. The collection of legal materials is then analyzed qualitatively.Results of the Research: Wildlife protection according to the CITES convention is discussed in the classification of endangered species, non-threatened species, and registered species based on Appendix I, Appendix II and Appendix III. Appendix I lists and protects all wild flora and fauna species that are threatened with extinction so that they are prohibited from all forms of international trade. Meanwhile, Appendix II contains a list of Appendix II that are not threatened with extinction, but may be threatened with extinction if the trade in these species is not controlled. Then on the Appendix. III contains a list of flora and fauna species that have been protected by a certain country within the boundaries of their habitat area. The state must be responsible for the preservation of protected animals. Indonesian national laws regarding the protection of wild animals as well as endangered species should be maximized by conducting socialization to the public. The perpetrators of trade in protected wildlife must be given appropriate punishment and the need for a firm attitude from the government towards those who trade in animals in order to provide a deterrent effect for the perpetrators
Eksploitasi Anak Jalanan Sebagai Manusia Silver Di Kota Bandar Lampung
Authors: Hasan Zainudin , Ristianti Refi Shely , Novita Elin , Ferianti Sarah Uli 
Published: October 2023

Introduction: Silver man is widespread in big cities in Indonesia, such as Jakarta, Surabaya, Yogyakarta, Bandung, and Lampung, and is expected to breed in 2020.Purposes of the Research: The purpose of this study is to describe one form of child exploitation, namely the silver man in the city of Bandar LampungMethods of the Research: The research methodology used is a normative legal research methodology.Results of the Research: Based on the results of the study, several children who became silver humans in Bandar Lampung City were reported to have done it on their own accord. Some claim that silver men have agencies that actively recruit them from various regions and place them in specific locations, usually at urban red lights. There are more silver age people who are children than those who drop out of school because these people cannot continue their education because of the weak economy. Some of them are still in school.
DIREITO E ODONTOLOGIA: ANÁLISE DOS PROCESSOS, PARECERES, ESPECIALIDADES E PARTICIPAÇÃO DO PERITO ODONTOLÓGICO EM UM TRIBUNAL DE JUSTIÇA
Authors: Mota Lavínia Cristina , Carvalho Thiago de Amorim 
Published: October 2023

Com o crescente conhecimento da população sobre seus direitos e um maior acesso à diversos serviços odontológicos, o número de processos contra o cirurgião dentista (CD) também obteve um aumento. Frente a isso o serviço de peritos odontológicos tornou-se extremamente importante para esclarecimento de eventuais processos, além de uma procura maior por partes dos profissionais da odontologia de se resguardar judicialmente. O objetivo do trabalho foi avaliar os pareceres da justiça acerca dos processos relacionados com a prática odontológica no estado de Minas Gerais, elencando as especialidades mais expostas a processos, bem como a participação do perito odontológico nesses ritos. Foi realizado um estudo retrospectivo, documental, de abordagem quali-quantitativa, onde não se aplicou avaliação ética. O presente estudo teve como método o levantamento de pesquisas a respeito de processos judiciais em todas as modalidades, no site do Tribunal de Justiça de Minas Gerais, elaborando um roteiro no Google Forms para o levantamento dos dados relevantes como: tipo de processo, especialidade odontológica do profissional, parte vencedora do processo e se houve presença de um perito odontológico. Os resultados demonstraram que decisões judiciais têm sido favoráveis ao cirurgião-dentista e que a especialidade mais acometida por processos é a implantodontia, e apesar de haver a presença de um perito na absoluta maioria dos casos, não foi possível estabelecer a dependência entre a presença deste profissional e o envolvimento do perito no processo.
Blue Farming Potentials: Sustainable Ocean Farming Strategies in the Light of Climate Change Adaptation and Mitigation
Authors: Bennett Michael , March Antaya , Failler Pierre 
Published: October 2023

Modern aquaculture technologies can contribute to both climate change mitigation and adaptation strategies while simultaneously contributing toward food security. Various aquaculture strategies have been reviewed elsewhere but omit a few key strategies worthy of inclusion. This paper reviews various regenerative aquaculture strategies that stimulate habitat creation, biodiversity and capture fisheriesstimulation, and increasing resilience to climate change effects. The climate change adaptation strategies discussed include integrated multi-trophic aquaculture (IMTA) and aquaponics, recirculation systems for the control of environmental conditions in a changing climate, habitat restoration through coral aquaculture, the capacity for selective breeding as adaptation mechanism to expected environmental changes, and continuous environmental monitoring programs. Blue farming strategies for climate change mitigation are largely focused on greenhouse gas reduction, carbon capture, and carbon sequestration. The Western hemisphere has recently been enthused by the development of seaweed aquaculture, and the implications of seaweed aquaculture and seaweed products are discussed, as well as the potential of seaweed to contribute to blue carbon stocks. The potential of microalgal bloom stimulation and open ocean fertilization are explored as methods of intensifying natural biogeochemical cycles involved in carbon sequestration. Best aquaculture practices and certifications are also discussed as a potential mechanism to align current farms with climate change and blue carbon objectives. The review concludes that regenerative aquaculture strategies have the potential to change public perception of aquaculture as holding largely negative consequences for the environment and encourage the development of other applications of aquaculture as novel methods of sustainable blue ocean farming.

Received: 18 April 2023 | Revised: 1 September 2023 | Accepted: 13 September 2023

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.
INTERNATIONALIZATION OF TRAINING METHODS OF PHYSICAL THEATER STUDENTS’ BY MEANS OF PLASTIC ART
Authors: Kulbaev Aman , Zhanguzhinova Meruyert 
Published: October 2023

Abstract. The relevance of the study is the interdisciplinary aspects of theater students’ psychophysiological training. The problem of the research is the differences in the approaches to education and students’ psychophysiological training of physical and stage schools.
The object of the research is educational aspects in the educational process, based on interdisciplinary research in the areas of psychophysiology, ethnopedagogy, traditional Kazakh values, synthesis of physical and stage schools, education, and art internationalization. The subject of the research is physical theater students’ psychophysiological sports training using performing arts. The purpose of the study is to determine the educational aspects of physical theater students’ psycho-physiological training by means of performing arts. The task of the study is to reveal the theoretical and methodological basis to create a methodic for the students’ psychophysiological training by means of performing arts. The research hypothesis is that when defining the goals and objectives of students’ psychophysiological training of physical and stage schools, it is possible to identify educational aspects for teaching profile disciplines methodic by means of performing arts. The methodological basis is based on the interdisciplinary study of researchers’ works in psychophysiology, students’ physical training, ethnopedagogy, traditional Kazakh values, performing arts, education, and art internationalization. Research methods: review-theoretical, psychophysiological, historical-culturological, art criticism, methodical-pedagogical analysis. The theoretical significance of the study lies in the scientific and theoretical justification of educational aspects of students’ psychophysiological training through the synthesis of physical and stage schools. The practical significance of the study is guided by using performing arts, tools of ethnopedagogy, and traditional Kazakh values, broadcast by performing arts. The results of the study made it possible to reveal the educational aspects of students’ psychophysiological training methodology by means of performing arts.
Alienation in the Plastic Arts: Ceramics as a Model
Authors: Al-Basha Narmin  Ramzi Qasim Mustafa , Al-Badran Oras Jabbar Suhaim 
Published: October 2023

The current research is concerned with studying (alienation in the plastic arts (ceramics as a model), as alienation was studied in terms of its effect on the artist, which in turn had its effect on the artistic work in formation, to be spatial discrepancies and displacements whose vocabulary is mixed with oppositions, disruption, and displacement, which create an apparent formal defect according to the contemporary perspective, with The development of technology and technique. Alienation appeared to be found in form in the plastic arts in general, and one of these arts is ceramics. Alienation in ceramics broke the traditional pattern and transcended the vocabulary of work associated with intellectual and conceptual transformations that resulted in the elements of alienation, including the art schools that brought about a shift in the artist’s concepts toward rejection. Everything that is familiar and traditional, as the artist sought to search for the idea that is different from the concept through the influence of the potter, which was achieved as a result of communication between art and society, which gives renewed concepts to the idea to achieve alienation according to the transformations of ceramic art, and the idea from which the potter started and developed treatments for reality through research was adopted.
E-commerce como medio para impulsar el mercadeo digital de productos
Authors: Campines Barría Francisco 
Published: October 2023

El comercio electrónico ha traído consigo importantes beneficios al marketing digital robusteciendo sus estrategias para lograr una efectiva comercialización de productos. El objetivo de la investigación ha sido conocer como el e-commerce ha influido en el mercadeo digital para impulsar la compra de productos en la comunidad estudiantil de la Facultad de Administración de Empresas y Contabilidad del Centro Regional Universitario de Veraguas. La metodología empleada tiene un enfoque cuantitativo de tipo descriptiva con un diseño no experimental, de corte transversal. 781 estudiantes, fue la población indagada, de los cuales 258 personas fue la muestra extraída. Se aplicaron preguntas a través de una encuesta apoyadas en la herramienta de Google Forms. Se muestra a través de los resultados obtenidos que un 55% de los encuestados ha comprado en línea, de estos el 45% lo ha hecho a través de redes sociales donde un 48% han comprado prendas de vestir.
Impact of Illness Perceptions on Poststroke Activity Engagement and the Moderating Role of Gender
Authors: Shi Yun , Howe Tsu-Hsin , Wu Bei 
Published: October 2023

Abstract
Importance: Beyond existing knowledge of demographic and performance skill factors, establishing relationships between poststroke activity engagement and illness perceptions sets the stage for the development of more effective intervention strategies.
Objective: To describe the illness perceptions of community-dwelling people with stroke in the first 2 yr poststroke; specifically, to examine whether illness perceptions are associated with activity engagement and to explore the moderating role of gender in these relationships.
Design: Cross-sectional study.
Setting: Participants were recruited from eight rehabilitation settings in Beijing, China.
Participants: 202 community dwellers with stroke.
Outcomes and Measures: Activity engagement and illness perceptions were measured with the Mandarin version of the Assessment of Life Habits and the Chinese version of the Stroke-Specific Illness Perceptions Questionnaire–Revised, respectively. Participants’ demographic information, cognitive status, and motor function were also collected.
Results: Stronger perceptions of consequences and controllability were related to better performance in activity engagement at the personal level, and stronger perceptions of illness coherence were related to better performance in activity engagement at the societal level. In addition, gender differences in the relationship between illness perceptions and activity engagement were described.
Conclusions and Relevance: How people with stroke perceived their conditions dictated their levels of activity engagement in their community of residence. The findings suggest that understanding clients’ illness perceptions may assist practitioners in developing comprehensive, targeted interventions to improve activity engagement and maximize recovery after stroke. Future studies are needed to explore the gender effect of illness perceptions on activity engagement in people with stroke.
What This Article Adds: This study identified the relationships between illness perceptions and level of activity engagement in real-life environments in people with stroke. In addition to motor and cognitive interventions, providing opportunities for clients to gain a better understanding of stroke would facilitate their activity engagement in their real-life environment.