bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol consumption among Iranian population: STEPS survey, 2021
Authors: Hajebi Amirali , Nasserinejad Maryam , Rezaei Negar , Azadnajafabad Sina , Rashidi Mohammad-Mahdi , Ahmadi Naser , Ghasemi Erfan , Farzi Yosef , Yoosefi Moein , Djalalinia Shirin , Fattahi Nima , Rezaei Shahabeddin , Mehr Elmira Foroutan , Kazemi Ameneh , Haghshenas Rosa , Rezaee Kamyar , Rankohi Azadeh Momen Nia , Afsari Massomeh , Mahdavihezaveh Alireza , Jamshidi Hamidreza , Farzadfar Farshad 
Published: January 2024

Abstract

Alcohol production and consumption have been prohibited in Iran for over four decades, leading to a typical underestimation of its consumption. This study aimed to assess the prevalence of alcohol consumption, its associated factors, and estimate per capita alcohol consumption among Iran's adult population. In this population-based survey, 27,874 adults from across Iran were selected using systematic proportional to size cluster sampling. Alcohol consumption was evaluated through a modified Persian version of the STEPS questionnaires from previous studies, applied over different timespans. Per capita consumption was calculated using the quantity-frequency method, expressed in liters of pure alcohol. Adjusted odds ratios were reported for associates of alcohol consumption concerning metabolic risk factors, sociodemographic elements, and lifestyle variables. The prevalence of lifetime alcohol consumption was 6.9% (95% CI: 6.5–7.2) in the adult population, with a notable sex difference (males: 13.7% [95% CI: 13-14.4]; females: 1.4% [95% CI: 1.1–1.6]). The 12-month prevalence was 3.8% (95% CI: 3.6–4.1). For individuals aged 18 and older, the per capita alcohol consumption in Iran was 0.12 liters. Factors such as being a lifetime smoker, younger, wealthier, and having 7–12 years of education were significantly linked to higher alcohol consumption. Significant associations were also observed between alcohol consumption and obesity, history of heart attacks, and physical injuries. The study revealed a complex relationship between alcohol consumption, behavioral risk factors, and metabolic profiles. Consequently, immediate preventive measures tailored to each factor's association with alcohol use are recommended.
Association between alcohol consumption and the risk of incident chronic kidney disease in community-dwelling older adults: a Korean nationwide population-based senior cohort study
Authors: SUN IN O , Lee Hui-Seung , Lim Chi-Yeon , Bae Eunjin , Hyun Young Youl , Chung Sungjin , Kwon Soon Hyo , Cho Jang-Hee , Yoo Kyung Don , Park Woo Yeong , Kim Hyunsuk , Yu Byung Chul , Ko Gang-Jee , Yang Jae Won , Hwang Won Min , Song Sang Heon , Shin Sung Joon , Hong Yu Ah 
Published: January 2024

Abstract
Background
The relationship between alcohol consumption and kidney function decline is not well established, especially in older adults. This study aimed to investigate the effects of alcohol consumption on the risk of incident chronic kidney disease (CKD) in community-dwelling older adults.
Methods
Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 and without proteinuria between 2009 and 2010 were recruited and followed through December 2018 from a Korean national population-based cohort. Alcohol consumption was categorised into non-, mild, moderate, and heavy drinking groups based on self-administered questionnaires. New-onset CKD was defined as an eGFR < 60 mL/min/1.73 m2.
Results
Of the total 122,319 subjects, the non-, mild, moderate, and heavy drinking groups were 99,091 (81.0%), 14,842 (12.1%), 4,257 (3.5%), and 4,139 (3.4%), respectively. During follow-up, 19,796 (20.0%), 4,636 (31.2%), 1,696 (39.8%), and 1,695 (41.0%) developed CKD in the non-, mild, moderate, and heavy drinking groups. Univariate Cox regression analyses showed a significantly increased risk of incident CKD in older adults in all drinking groups compared to non-drinkers (all P < 0.001). However, hazard ratios (HR) for developing CKD were 0.90 (95% confidence interval [CI] 0.87–0.94, P < 0.001) for mild, 0.89 (95% CI 0.84–0.95, P < 0.001) for moderate, and 0.93 (95% CI 0.88–0.99, P = 0.027) for heavy drinkers after fully adjusting for confounding variables. This inverse relationship between alcohol consumption and CKD risk was observed in males in all drinking groups, whereas in females it was found only in mild drinkers.
Conclusion
In the subgroup analysis, the beneficial effect of alcohol consumption on incident CKD was prominent among moderate drinkers aged 65–75 years, male mild drinkers aged ≥ 75 years, and female mild drinkers aged < 85 years. This study shows that alcohol consumption is inversely associated with the risk of incident CKD in older adults. Further studies are required to elucidate the effects of alcohol on kidney damage in older adults.
Exploration of the association between inflammatory cytokines and development of new-onset atrial fibrillation in critically ill patients: a retrospective cohort study
Authors: Derocher Heather , Muscedere John , Maslove David M. , Boyd J. Gordon , Day Andrew G. , Sibley Stephanie 
Published: January 2024

Abstract

BackgroundNew-onset atrial fibrillation (new AF) in critically ill patients is associated with increased morbidity and mortality. There has been evidence linking atrial fibrillation with inflammation in both the setting of chronic atrial fibrillation and critical illness. In this study we compare serum inflammatory marker levels in patients admitted to the intensive care unit (ICU) with no atrial fibrillation (AF), chronic AF, and new AF.MethodsA retrospective chart review was performed on 129 mechanically ventilated, critically ill patients from the PREVAIL trial. History of cardiovascular disease, previous AF, and development of new AF were documented. Inflammatory cytokines TNFα, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, granulocyte-colony stimulating factor, granulocyte-macrophage colony-stimulating factor, interferon-γ, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1b had been collected as part of the PREVAIL trial and were compared between three patient groups, those with no AF, chronic AF, and new AF.ResultsHigher APACHE II scores were found in patients with chronic AF (28.0±8.7) and new AF (27.1±6.2) compared to patients with no AF (23.0±7.2). No significant differences were found between groups in any inflammatory markers at baseline or on admission days 4 or 7.ConclusionWe found no clear association between the studied inflammatory markers and the development of new AF, although this may be related to the timing of sampling. Further study is required to better elucidate the relationship between inflammatory cytokines and the development of new AF in critically ill patients.
Effectiveness of osteopathic craniosacral techniques: A meta-analysis
Authors: Amendolara Alfred , Sheppert Alexander , Powers Ryan , Payne Andrew , Stacey Stephen , Sant David 
Published: January 2024

Abstract

Background
Craniosacral osteopathic manipulative medicine—also known as craniosacral therapy (CST)—is a widely taught component of osteopathic medical education. It is included in the standard curriculum of osteopathic medical schools, despite controversy surrounding its use. This paper seeks to systematically review and conduct a meta-analysis of randomized controlled trials assessing the clinical effectiveness of CST compared to standard care, sham treatment, or no treatment in adults and children.
Methods
A search of Embase, PubMed, and Scopus was conducted on 10/29/2023. There was no restriction placed on the date of publication. Additionally, a Google Scholar search was conducted to capture grey literature. Backward citation searching was also implemented. All randomized controlled trials employing CST for any clinical outcome were included. Studies not available in English as well as any studies that did not report adequate data for inclusion in the meta-analysis were excluded. Multiple reviewers were used to assess for inclusions, disagreements were settled by consensus. PRISMA guidelines were followed in the reporting of this meta-analysis. Cochrane’s Risk of Bias 2 tool was used to assess for risk of bias. All data were extracted by multiple independent observers. Effect sizes were calculated using a Hedge’s G value (standardized mean difference) and aggregated using random effects models.
Results
The primary study outcome was the effectiveness of CST for selected outcomes as applied to non-healthy adults or children and measured by standardized mean difference effect size. Twenty-four RCTs were included in the final meta-analysis with a total of 1,613 participants. When results were analyzed by primary outcome, no significant effects were found. When secondary outcomes were included, results showed that only Neonate health, structure (g = 0.66, 95% CI [0.30; 1.02], Prediction Interval [-0.73; 2.05]) and Pain, chronic somatic (g = 0.34, 95% CI [0.18; 0.50], Prediction Interval [-0.41; 1.09]) show reliable, statistically significant effect. However, wide prediction intervals and high bias limit the real-world implications of this finding.
Conclusions and Relevance:
CST did not demonstrate broad significance in this meta-analysis, suggesting limited usefulness in patient care for a wide range of indications.
Semi-passive pilot scale bioreactors metal(loid) removal performance response to seasonal freeze-thaw cycle
Authors: Desmau Morgane , Simister Rachel , Baldwin Susan A. , Nielsen Guillaume 
Published: January 2024

Abstract

Managing mine-contact water effectively and sustainably in (sub)arctic regions is crucial for expanding mining activities. The demand for cost-effective (semi-)passive water treatment that relies on natural chemical and biological processes and can withstand challenging weather conditions is increasing. This study investigated the ability of four pilot-scale bioreactors inoculated with locally sourced bacteria andaffected by a freeze-thaw cycle to effectively remove selenium and antimony. The bioreactors were operated at a Canadian subarctic mine for a year. Two duplicate bioreactors were installed in a heated shed maintained at 5°C over winter, while two other duplicates were installed outdoors and left to freeze. The removal rate of selenium and antimony was monitored weekly, while a genomic characterization of the microbial populations in the bioreactors was performed monthly. The bioreactors successfully removed selenium and antimony over the year, demonstrating their ability to manage freeze-thaw cycles. The overall percentage of selenium and antimony removal was similar in the outside and inside bioreactors, apart from the spring thawing period, when removal in the outdoors bioreactors was slightly lower. The dominant taxonomic groups of microbial populations were similar in all bioreactors, with slight variations observed in their relative abundance over time. The microbial population composition was consistent and re-established quickly after spring thaw in the outside bioreactors. This study demonstrated that the removal capacity of bioreactors inoculated with locally sourced bacteria was not largely affected by a freeze-thaw cycle, highlighting the strength of using local resources to design bioreactors in extreme climatic conditions.
Association between sleep disorders and physical activity in middle-aged Americans: Data from NHANES 2007-2018
Authors: Fei ZhiYing , Zhu XiaoYing , Shan QiDan , Wan FangYuan , Tu YingYing , Lv XiaoHeng 
Published: January 2024

Abstract

Background: Despite numerous studies on physical activity and sleep disorders, few have focused on physical activity and sleep disorders in middle-aged people who are particularly stressed. A restricted cubic web (RCS) technique was applied to determine whether there is a dose-response relationship between physical activity and the self-rated prevalence of sleep disorders in middle-aged adults.
Methods: This study analyzed 8880 middle-aged adults aged 40-65 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) between physical activity and the risk of sleep disorders in middle-aged adults. Thereafter, the dose-response connection was examined using RCS.
Results: After adjusting for potential confounders, subjects with MET values in the first quartile (Q1) compared to subjects with MET values in the second, third, and fourth quartiles had odds ratios (OR) for sleep disturbance that were0.851(95% CI=0.745–0.973), 0.800 (95% CI = 0.698–0.917) and 0.780 (95% CI = 0.680–0.895) , respectively. RCS regression showed a non-linear association between physical activity and sleep disorders in middle-aged adults (non-linearity P=0.0382). Furthermore, the prevalence of sleep disorders in middle-aged adults decreased with increasing physical activity, reaching a minimum when weekly physical activity was around 166.27MET*h(OR=0.885, 95% CI=0.799–0.981).
Limitations：Self-reporting of sleep disorder and physical activity may be biased.
Conclusion: Our research demonstrates that physical activity was associated with a reduced risk of sleep disorders.
Timing and co-occurrence of symptoms prior to a diagnosis of light chain (AL) amyloidosis
Authors: D'Souza Anita , Singh Ashima , Szabo Aniko , Lian Qinghua , Pezzin Liliana , Sparapani Rodney 
Published: January 2024

Abstract

It is well-established that light chain (AL) amyloidosis patients have multi-organ involvement and are often diagnosed after a lag period of increasing symptoms. We leverage electronic health record (EHR) data from the TriNetX research network to describe the incidence, timing, and co-occurrence of precursor conditions of interests in a cohort of AL amyloidosis patients identified between October 2015-December 2020. Nineteen precursor diagnoses of interest representing features of AL amyloidosis were identified using ICD codes up to 36 months prior to AL amyloidosis diagnosis. Among 1,401 patients with at least 36 months of EHR data prior to AL amyloidosis diagnosis, 46% were females, 16% were non-Hispanic Black, and 6% were Hispanic. The median age was 71 (range, 21–91) years. The median number of precursor diagnoses was 5 with dyspnea and fatigue being the most prevalent. The time from the first occurrence of a precursor to AL diagnosis ranged from 3.2 to 21.4 months. Analyses of pairwise co-occurrence of specific diagnoses indicated a high association (Cole’s coefficient > 0.6) among the examined precursor diagnoses. These findings provide novel information about the timing and co-occurrence of key precursor conditions and could be used to develop algorithms for early identification of AL amyloidosis.
Core-periphery structure of a medicinal botanical system in Uruguay
Authors: Latorre Elena Castiñeira , Borthagaray Ana , Canavero Andrés 
Published: January 2024

Abstract

Background: Human evolution has granted upon individual’s cognitive mechanisms necessary for remembering experiences, vital for both survival and reproduction. These experiences manifest into cultural traits, influencing human culture, particularly in healthcare and maintenance. Studies regarding medicinal plants and treatments are integral to the study of the medical botanical system. Pharmacopeias highlight the prevalence of specific species widely used, aligning with the “consensus within diversity theory” in evolutionary ethnobiology.
Methods: This study applies network analysis on the botanical system of “Parque Regional Quebradas del Norte”, Rivera, Uruguay.
Results: Study results demonstrate a core-periphery structure, with a tightly interconnected core resistant to fragmentation, ensuring structural stability. This study showed the existence of peripheral nodes in the entire system, improving resilience against disturbances and increasing population's health.
Conclusion: The core species, renowned for their versatility and multiple medicinal uses, treating less severe ailments effectively. Additionally, core plants serve as prototypes for innovations. Their extinction poses a threat to the system's resilience. Conversely, peripheral plants, though vulnerable, offer possibilities for therapeutic innovations. In the face of environmental change, conservation efforts should prioritize species that are vulnerable to extinction, particularly within the core. Simultaneously, preserving knowledge associated with peripheral plants presents a bicultural conservation strategy, ensuring the botanical system's robustness amongst evolving ecological conditions.
Factors affecting self-perceived mental health in the general older population during the Covid19 pandemic: a cross-sectional study
Authors: Koppner Jenny , Lindelöf Ann , Iredahl Fredrik , Tevell Maxine , Nilsson Staffan , Thorsell Annika , Faresjö Åshild , Larsen Hanna Israelsson 
Published: January 2024

Abstract
Background
Mental health problems among older people are large public health concerns but often go unrecognized and undertreated. During Covid-19 several restrictions regarding social contacts were launched, primarily for the old. The objective of this study is to investigate which factors that had the main negative affect on mental health in the older population during the pandemic.
Method
A cross-sectional cohort study set in Swedish primary care during the pandemic years 2021–2022. The population constitutes of 70-80-years-old, N = 260. Instruments used are Geriatric depression scale 20 (GDS20); Hospital anxiety and depression scale (HADS), and Perceived stress scale 10 (PSS10). Sociodemography and risk factors are explored. Outcome measures are factors independently associated with decreased mental health. Analyses were performed for the group as a whole and with logistic regression models comparing individuals who stated they were mentally affected by the pandemic to individuals who stated they were not.
Results
Participants who stated they were mentally affected by the Covid − 19 pandemic reported significantly higher levels of anxiety (p < 0.001), depression (p < 0.001), and stress (p = 0.026) compared to those who stated they were not mentally affected. Explanatory regression models of up to 50% showed that following factors were prominent among individuals who experienced a decline in their mental health due to the Covid − 19 pandemic (n = 24); impaired social life (OR 16.35, p < 0.001, CI 4.17–16.05), change in physical activity (OR 5.76, p = 0.006, CI 1.67–19.87), perceived family situation (OR 30,36, p = 0,008, CI 2,41–382,75), mild/moderate and high anxiety (OR 3.9, p = 0.043, CI 1.37–24.33, OR 10,8, p = 0.011, CI 1.34–57.15 respectively), and female gender (OR 4.7, p = 0.05, CI 1.04–26.15).
Conclusion
Anxiety, family situation, social life and change in physical activity were the main factors influencing the 70-80-years-old’s self-perceived mental health during the Covid-19 pandemic. Long-term effects of social restrictions on mental health in the older population need to be further investigated.
Unveiling Sociotherapists' Coping Resources: Exploring Professional Experiences through Thematic Analysis
Authors: Jankowiak Barbara , Soroko Emilia , Pietrzak Sebastian , Wilk Maciej 
Published: January 2024

Abstract
Sociotherapy is a widely used form of psychological and pedagogical group help for children and adolescents in Poland. However, it is still unknown under this name, which causes its marginalization in scientific research. Knowing that sociotherapists face myriad challenges in working with individuals, groups, and systemic challenges, we decided to examine the coping strategies that led them to successful outcomes while working with adolescents. We conducted in-depth interviews with 22 sociotherapists (aged 28–60), asking them to share narratives of difficulties they overcame at work. We analyzed the resulting statements about the subjects' experience using reflective thematic analysis. We created the following themes, which reflect the structure of resources (themes), mobilized by the sociotherapists: 1) “I can rely on other professionals”; 2) “I am ready to work on and with myself”; 3) “I am ready to be a container for their feelings”; 4) “I need to take action!”; 5) “But I'm a sociotherapist, and I have a mission!”. Findings show that effective coping involves seeking support from professionals and acknowledging a personal growth in the work environment. Supervision and crisis intervention policies may become vital resources for sociotherapists. Broader access to societies can strengthen their professional role and foster a community-supported principle of good practice in sociotherapy.
Complete genomic sequence of a novel botourmiavirus infecting the fungus Phomopsis asparagi
Authors: Zhou Jingyi , Liu Shuang , Xu Yun , Yan Junhan , Xie Changping , Zheng Li , Chen Daipeng 
Published: January 2024

Abstract
Here, we report a novel ourmia-like mycovirus, named “Phomopsis asparagi magoulivirus 1” (PaMV1), derived from the phytopathogenic fungus Phomopsis asparagi. The complete genome sequence of PaMV1 consisted of a positive-sense single-stranded RNA (+ ssRNA) of 2,639 bp in length with a GC content of 57.13%, containing a single open reading frame (ORF) which encodes a putative RNA-dependent RNA polymerase (RdRp) of 686 amino acids with a molecular mass of 78.57 kDa. RdRp phylogeny indicates that PaMV1 grouped together with Diaporthe gulyae magoulivirus 1 (DgMV1) forming a distinct clade. The results of RdRp sequence homology comparisons and phylogenetic analysis suggested that PaMV1 is a new member of the genus Magoulivirus within the family Botourmiaviridae.
Effect of lidocaine on prevention of postoperative delirium in elderly patients with intrathecal anesthesia:A randomized, controlled, double-blind prospective study
Authors: Lin Longxiang , Li Yan , Zheng Hong , Pan Lezhou , Chen Mengmeng , Lian Chaohui , ShangGuan Wangning 
Published: January 2024

Abstract

Background
Earlier findings have shown that elderly individuals are at high risk for postoperative delirium. Although the pathogenesis of this disease is still under study, it has been suggested that the release and inhibition of inflammatory factors contribute to its pathogenesis. Lidocaine is considered to have outstanding anti-inflammatory properties. The aim of this study was to observe changes in cognitive function after intraoperative lidocaine pump placement in elderly patients who underwent hip replacement surgery after intrathecal anesthesia.
Methods
Patients aged 60 to 80 years were selected as study subjects and randomly divided into a lidocaine group and a saline group. The Mini Mental State Examination(MMSE) score was assessed on the day before surgery (T1) and the third day after surgery (T2) for comparison. Venous blood samples were taken on T1, T2 and the fifth day after surgery (T3) for the detection of inflammatory factors.
Results
Statistical analysis of the data showed that, compared with those in the lidocaine group, the saline group had a lower MMSE score at T2 (26.6 ± 1.5 vs. 28.0 ± 0.9, P < 0.01) and a greater concentration of the proinflammatory factor interleukin-6 (172.4 ± 85 vs. 129.4 ± 46, P = 0.018). In addition, the concentration of the S100β protein in the lidocaine group decreased after reaching a peak at T2, which was not evident in the saline group.
Conclusions
These findings suggest that lidocaine may protect the nervous system by reducing the release of proinflammatory factors rather than increasing the release of anti-inflammatory factors.
Trial registration
This study was registered at ChineseClinicalTrials.gov ChiCTR2000039540 (30/10/2020).