bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON OF THE FINANCIAL PERFORMANCE OF MICRO AND SMALL BUSINESSES BEFORE AND AFTER GET FINANCIAL ASSISTANCE AT MICRO AND SMALL ENTERPRISES OF JEKA MEMBERS
Authors: Budiono Karim , Anggraeni Yulia , Rachmawati Ratih , Subagyo Amar 
Published: January 2024

This study aims to determine whether there is a significant difference between the financial performance of JEKa member SMEs before and after receiving financial assistance. The population in this study were 109 members of SMEs of JEKa Jember. The data analysis method used were a descriptive quantitative percentage and the Manova test. The results showed that there was a significant difference between the financial performance of SMEs members of JEKa Jember before and after receiving financial assistance interms of Liquidity Ratios (CRR, QR, CR), Solvency Ratios (DTAR, DER), Rentability Ratios (PM, NPM, GPM, ROI, ROA) and there is no significant difference between the financial performance of JEKa member SMEs before and after receiving financial assistance in terms of Activity Ratios (ITR, RTR, FATO, TATO)
Expert System For Diagnosing Alzheimer's Using Certainty Factor Method
Authors: Azim Fauzan , Firdausi Faiz , Afrianto Eko 
Published: January 2024

This expert system for diagnosing Alzheimer's disease is a computer-based stem system used as a tool to diagnose Alzheimer's disease based on a dynamic knowledge base. This knowledge base contains knowledge obtained from various sources including from the experience of experts who are proficient in their fields and also books related to diagnosis of Alzheimer's disease and then collected into a database system needed for making conclusions. In this system, the certainty factor method will be used using a forward chaining inference engine. The purpose of making this root stem p can be useful for many people and can know clearly about Alzheimer's disease from its symptoms and solutions, which will be displayed in the form of a website using PHP programming with MySQL database.
PENINGKATAN KADAR KARBON MONOKSIDA EKSPIRASI PADA PENGEMUDI OJEK PEROKOK DI JAKARTA BARAT
Authors: Tubagus Muhammad Sya'bani  , Rita Khairani  
Published: January 2024

Penelitian ini bertujuan untuk menilai adanya korelasi antara kadar karbon monoksida ekspirasi pada pengemudi ojek.Penelitian ini menggunakan desain potong lintang. Responden yang terlibat merupakan pengemudi ojek di Jakarta, berjumlah 170 orang, yang memenuhi kriteria inklusi dan eksklusi yang telah ditetapkan. Pengambilan data menggunakan wawancara kuesioner Indeks Brinkman dan Global Physical Activity Questionnaire (GPAQ), serta pemeriksaan COHb dengan menggunakan Smokelyzer. Analisis data menggunakan uji statistik korelasi Spearman. Batas kemaknaan p<0,05. Hasil penelitian menunjukkan, frekuensi merokok berada pada klasifikasi berat (37.1%). Sebagian besar intensitas aktivitas fisik berada pada klasifikasi ringan (54.1%). Karakteristik kadar karbon monoksida diklasifikasikan menjadi ringan-sedang (26.5%) dan berat-sangat berat (73.5%). Analisis bivariat menunjukan terdapat korelasi positif lemah bermakna antara merokok dengan COHb. (r = 0.347; p = <0.001), dan terdapat korelasi negatif lemah bermakna antara aktivitas fisik dan COHb. (r = -0.258 ; p = 0.001).
Strategi Telecommuting Work: Sejauh Mana Pengaruhnya terhadap Kepuasan Kerja dan Kinerja
Authors: Suryani Irma , Amalia Rizki , Zainul Zaida Rizqi , Rahmani Sari , Riamanda Irin 
Published: January 2024

This study focuses on the relationship between telecommuting work with performance, job satisfaction, and work-life balance. This research is important because the telecommuting policy has been taken by many institutions considering the advantages of this policy are very efficient, such as reducing costs, time, and space. This study aims to provide an overview of the extent to which the impact of telecommunications works on the behavior of workers, especially workers in a university environment. Using descriptive research methods, this research used online questionnaires distributed to 174 lecturers at Syiah Kuala University. The data was analysed using SEM AMOS to see and test the relationship between variables. The results showed that telecommuting work showed a positive and significant relationship to job satisfaction, work-life balance, and performance. Likewise, the relationship between work-life balance, satisfaction, and performance showed positive and significant results. Finally, work-life balance and job satisfaction mediate the relationship between telecommuting work and performance.
Keywords: Telecommuting Work, Job Performance, Job Satisfaction, Work-Life Balance.
Prevalencia de enteroparasitosis después de una intervención educativa y farmacológica en estudiantes de una unidad educativa rural, Chimborazo, Ecuador
Authors: González Ramírez Luisa Carolina , Yugcha Verdesoto Aracelly Ibeth , Robles Reyes Rosa Angélica , Monar Basantes Silvia Paola 
Published: January 2024

Introducción. Las parasitosis intestinales son un problema de salud que no recibe la atención que merece, en Ecuador, la prevalencia parasitaria es significativamente mayor en zonas rurales (80%) que urbanas (20-40%), siendo los escolares más propensos a adquirir enteroparásitos. Objetivo. Evaluar la prevalencia de enteroparasitosis, después de una intervención educativa y farmacológica con un antiparasitario de amplio espectro en estudiantes que asisten a una Unidad Educativa de Guano-Chimborazo. Metodología. Se realizaron análisis coproparasitarios a 18 estudiantes (5 y 13 años). La investigación es descriptiva, de cuasiexperimental, longitudinal, ambispectiva y cuantitativa. Se recolectó una muestra fecal por individuo, posteriormente se realizaron análisis utilizando diferentes técnicas: examen directo, Ritchie, Kato-Katz y Ziehl-Neelsen. Resultados. Se comprobó una disminución porcentual de la prevalencia total de parasitismo de 100% a 88,9%, sin lograr alcanzar significancia estadística (X2 =2,118; P=0,1456), este resultado estuvo condicionado por la menor prevalencia de Endolimax nana que se redujo de 72,2 a 44,4% y Giardia duodenalis de 11,1 a 5,5%. Por el contrario, se encontró el aumento porcentual del Complejo Entamoeba de 16,6 a 27,7%, Entamoeba coli de 33,3 a 38,8%; Entamoeba hartmanni de 38,8 a 44,4%; Iodamoeba butschlii de 0 a 16,6%; Chilomastix mesnili de 5,5 a 33,3% y Blastocystis sp., de 55,5 a 61,1% Conclusión. No fue suficiente la capacitación educativa y el tratamiento antiparasitario aplicado, es necesario que se intensifique las medidas higiénicas, se intervenga de nuevo la población con un programa sistemático de educación higiénica y las autoridades competentes mejoren las instalaciones sanitarias para lograr que las infecciones disminuyan significativamente. Área de estudio general: Laboratorio Clínico. Área de estudio específica: Parasitología. Tipo de estudio: Artículos originales.
Identificación y caracterización microbiológica del Streptococcus mutans en saliva de madre – hijo, Riobamba, Ecuador
Authors: González Romero Ana Carolina , Guillén Ferraro Morella Lucia , Cruz Tenempaguay Rosa Elisa , Martínez Durán Eliana Elizabeth 
Published: January 2024

Introducción. La caries dental es una de las enfermedades infecciosas más frecuentes, Streptocococcus mutans, es el principal agente etiológico asociado con el inicio de esta enfermedad. Objetivo. Identificar y caracterizar microbiológicamente la presencia de S. mutans en muestras de saliva de madres e hijos de Centros de Desarrollo Infantil del Gobierno Autónomo Descentralizado Municipal, Riobamba, Ecuador. Metodología. Estudio de campo, con diseño no experimental, de corte transversal y enfoque cuantitativo. La muestra estuvo compuesta por 111 niños, en edades entre 1 y 4 años, seleccionados de 5 centros de desarrollo infantil del Gobierno Autónomo Descentralizado Municipal de Riobamba y, 27 madres de esos niños. Se recolectaron muestras de saliva no estimulada, que fueron analizadas en el laboratorio de Microbiología de la Universidad Nacional de Chimborazo. Se realizaron cultivos en agar mitis salivarius para realizar el recuento de las colonias con características típicas de S. mutans, seguido de su identificación mediante pruebas bioquímicas convencionales. Los resultados obtenidos fueron analizados estadísticamente utilizando frecuencias absolutas y relativas. Resultados. De los 111 niños estudiados, se detectó S. mutans en la saliva de 55 (49,5%) de ellos y de éstos, 39 (79%) mostraron un riesgo cariogénico de nivel medio. Con respecto a las madres, solo 27 accedieron a colaborar. De ellas, 9 (33,3%) presentaron el microorganismo. En relación con el riesgo cariogénico se observó que en 7 (25,9%) tenía un riesgo medio, con valores entre 8 y 70 UFC. Conclusión. Los resultados obtenidos indican un incremento en el riesgo de caries dental entre la población infantil objeto de estudio, revelando que el 49,5% de los casos examinados presentaban S. mutans. Estos hallazgos pueden desempeñar un papel crucial como indicadores para orientar la implementación de estrategias en programas de prevención de salud bucal. Área de estudio general: Salud. Área de estudio específica: Microbiología. Tipo de estudio: Artículo original.
Aprendizaje por inmersión con recursos didácticos virtuales en la enseñanza de Neuroanatomía
Authors: Gualpa Jaramillo Guillermo Gonzalo , De la Calle Andrade Lucila Jazmín , Barba Maggi María Angélica , Fernández Villacrés Gustavo Eduardo 
Published: January 2024

Introducción. La educación en la virtualidad requiere la adaptabilidad tanto de los estudiantes como de los docentes. Mediante el estudio realizado se pretendió demostrar la importancia que tienen estas tecnologías de la información en el aprendizaje formativo de la medicina desde sus bases anatómicas. Objetivo. Elaboración un museo virtual, así como su difusión en la Web de acceso gratuito y la evaluación del impacto en los estudiantes participantes, tanto en la elaboración de este, como en el grado de satisfacción del curso con esta metodología. Metodología. Para llevar a cabo la investigación, se realizó un estudio cuantitativo, descriptivo, transversal, de campo y no experimental. Participaron 27 estudiantes de la asignatura de Neuroanatomía, con la elaboración de todo el material a ser utilizado, modelos tridimensionales, maquetas anatómicas y técnicas gráficas e incluso disecciones en tejidos no humanos; para la evaluación de la participación del proceso en el aprendizaje y satisfacción se utilizaron dos cuestionarios de encuestas auto aplicables diseñadas para este fin. Resultados. El 70,4% de los estudiantes encuestados se encontraron muy satisfechos con el contenido de la asignatura impartida en el periodo académico, así mismo, el 92,6% de los estudiantes adquirieron los conocimientos adecuados para el semestre que cursaron y el 85,2 % de ellos indicaron que tuvieron un buen grado de satisfacción. Conclusiones. Los resultados alcanzados sobre la satisfacción con los contenidos y conocimientos adquiridos permitieron demostrar la importancia de aplicar innovadores métodos utilizando las herramientas digitales. En consecuencia, la inmersión de los estudiantes en la elaboración del museo digital contribuyó a incrementar su aprendizaje con un buen grado de satisfacción. Área de estudio general: Medicina. Área de estudio específica: Neuroanatomía. Tipo de estudio: Artículos originales / Original articles.
‘Sans offenser l'ordre’: Voice, Order, and Gender in Les Caquets de l'accouchée (1622)
Authors: Horsley Adam 
Published: January 2024

This article considers a series of satirical pamphlets written against women – Les Caquets de l'accouchée – in which the male narrator covertly records women's gossip in the bedroom of a recently delivered woman. Scholars have largely focussed on the fluid gender identity of a male visitor within this sphere of all-female sociability. This study instead takes a closer look at the accouchée's visitors, in order to demonstrate that their identity, and the subjects of their quarrelling, are more than they first appear. Drawing from early modern dichotomy between conservative masculine order and female disorder, this study aims to show that female characters in the Caquets are not mere satires of female discourse. Rather, they are a hybrid blend of misogynistic views on the female intellect, and paradoxically, the mouthpieces for a conservative, nostalgic return to order which contemporaries would have regarded as antithetically masculine.
Chromatographic single-step purification of tagless proteins using gp41-1 split inteins
Authors: Knapp Michael , Kohl Vanessa , Best Tatjana , Rammo Oliver , Ebert Sybille 
Published: January 2024

The current trend in biopharmaceutical drug manufacturing is towards increasing potency and complexity of products such as peptide scaffolds, oligonucleotides and many more. Therefore, a universal affinity purification step is important in order to meet the requirements for cost and time efficient drug production. By using a self-splicing intein affinity tag, a purification template is generated that allows for a universal chromatographic affinity capture step to generate a tagless target protein without the use of proteases for further tag removal. This study describes the successful implementation of gp41-1-based split inteins in a chromatographic purification process for, e.g., E. coli-derived targets. The tagless target is generated in a single-step purification run. The on-column cleavage is induced by triggering a simple pH change in the buffer conditions without the need for additives such as Zn2+ or thiols. This system has proven to be reusable for at least ten purification cycles that use 150 mM H3PO4 as the cleaning agent.
A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination
Authors: Shi Jane , Danesh-Meyer Helen V. 
Published: January 2024

BackgroundIt has become increasingly clear that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect most organs in the human body, including the neurologic and ophthalmic systems. Vaccination campaigns have been developed at rapid pace around the world to protect the population from the fast-mutating virus. This review seeks to summarise current knowledge of the neuro-ophthalmic manifestations of both COVID-19 infection and vaccination.Evidence acquisitionElectronic searches for published literature were conducted using EMBASE and MEDLINE on the 30th of July 2023. The search strategy comprised of controlled vocabulary and free-text synonyms for the following terms in various combinations: “coronavirus, COVID-19, SARS-CoV-2, 2019-nCoV, vaccination, vaccine, immunisation and neuro-ophthalmology”. No time range limits were set for the literature search. Published English abstracts for articles written in a different language were screened if available.ResultsA total of 54 case reports and case series were selected for use in the final report. 34 articles documenting neuro-ophthalmic manifestations following COVID-19 infection and 20 articles with neuro-ophthalmic complications following COVID-19 vaccination were included, comprising of 79 patients in total. The most commonly occurring condition was optic neuritis, with 25 cases following COVID-19 infection and 27 cases following vaccination against COVID-19.ConclusionsThe various COVID-19 vaccines that are currently available are part of the global effort to protect the most vulnerable of the human population. The incidence of neuro-ophthalmic consequences following infection with COVID-19 is hundred-folds higher and associated with more harrowing systemic effects than vaccination against the virus.
A systematic review of the effectiveness of online learning in higher education during the COVID-19 pandemic period
Authors: Meng Wentao , Yu Lei , Liu Chen , Pan Nengchao , Pang Xiawen , Zhu Yunyun 
Published: January 2024

BackgroundThe effectiveness of online learning in higher education during the COVID-19 pandemic period is a debated topic but a systematic review on this topic is absent.MethodsThe present study implemented a systematic review of 25 selected articles to comprehensively evaluate online learning effectiveness during the pandemic period and identify factors that influence such effectiveness.ResultsIt was concluded that past studies failed to achieve a consensus over online learning effectiveness and research results are largely by how learning effectiveness was assessed, e.g., self-reported online learning effectiveness, longitudinal comparison, and RCT. Meanwhile, a set of factors that positively or negatively influence the effectiveness of online learning were identified, including infrastructure factors, instructional factors, the lack of social interaction, negative emotions, flexibility, and convenience.DiscussionAlthough it is debated over the effectiveness of online learning during the pandemic period, it is generally believed that the pandemic brings a lot of challenges and difficulties to higher education and these challenges and difficulties are more prominent in developing countries. In addition, this review critically assesses limitations in past research, develops pedagogical implications, and proposes recommendations for future research.
Global scientific trends on thyroid disease in early 21st century: a bibliometric and visualized analysis
Authors: Song Mingyuan , Sun Wei , Liu Qi , Wang Zhongqing , Zhang Hao 
Published: January 2024

BackgroundBibliometrics has been used to analyze the literature in the field of thyroid disease studies in the early 21st century, indicating the changes in current international study trends.MethodsIn this study, a bibliometric analysis of data retrieved from the Web of Science (WoS) database was conducted, and the publication trends and thematic evolution in the field of thyroid disease research from January 1, 2000, to November 16, 2022, were analyzed. A total of 69283 articles related to thyroid diseases were evaluated for their characteristics, including annual publication volume, countries, journals, institutions, authors, keywords, and references. VOSviewer was utilized to perform the analysis of co-authorship, co-citation, co-occurrence and descriptive.ResultsThe annual publication volume of thyroid disease research literature showed a fluctuating upward trend from 2000 to 2021, exceeding 5,000 articles for the first time in 2021. The United States (16120 counts, 678255 cities) ranks first in terms of publication volume and citation. Thyroid (n=3201) and Journal of Clinical Endocrinology&amp;Metabolism (n=140399) are the most prolific and cited journals, respectively. The organization with the highest publication volume and citation frequency is Harvard University (1011 counts, 59429 cities), Miyauchi Akira (n=422), Schlumberger, and Martin (n=24839) possess the highest publication volume and citation frequency, respectively. Co-occurrence analysis of 307 keywords with frequencies of more than 20 resulted in 6 clusters (1): Thyroid dysfunction and diseases (2); mechanism of occurrence and development of thyroid cancer (3); autoimmune thyroiditis (4); scope and postoperative management of thyroid surgery (5); fine needle aspiration of thyroid nodules (6); radioactive iodine therapy for thyroid cancer. Active monitoring, thermal ablation, Lenvatinib, and long noncoding RNA refer to the latest keywords. Discussing the six clusters helps scholars to determine the scope and direction of studies.ConclusionOver the past two decades, the literature related to thyroid diseases has increased year by year, with closer collaboration between countries, institutions, and authors. In this study, the global trends, research hotspots, emerging subjects, and basic knowledge of literature related to thyroid diseases were respectively elucidated, which will facilitate researchers in this field to seek better development.
The impact of air pollution on interstitial lung disease: a systematic review and meta-analysis
Authors: Lan Doris , Fermoyle Caitlin C. , Troy Lauren K. , Knibbs Luke D. , Corte Tamera J. 
Published: January 2024

IntroductionThere is a growing body of evidence suggesting a causal relationship between interstitial lung disease (ILD) and air pollution, both for the development of the disease, and driving disease progression. We aim to provide a comprehensive literature review of the association between air pollution, and ILD, including idiopathic pulmonary fibrosis (IPF).MethodsWe systematically searched from six online database. Two independent authors (DL and CF) selected studies and critically appraised the risk of bias using the Newcastle-Ottawa Scale (NOS). Findings are presented through a narrative synthesis and meta-analysis. Meta-analyses were performed exclusively when there was a minimum of three studies examining identical pollutant-health outcome pairs, all evaluating equivalent increments in pollutant concentration, using a random effects model.Results24 observational studies conducted in 13 countries or regions were identified. Pollutants under investigation encompassed ozone (O3), nitrogen dioxide (NO2), Particulate matter with diameters of 10 micrometers or less (PM10) and 2.5 micrometers or less (PM2.5), sulfur dioxide (SO2), carbon monoxide (CO), nitric oxide (NO) and nitrogen oxides (NOx). We conducted meta-analyses to assess the estimated Risk Ratios (RRs) for acute exacerbations (AE)-IPF in relation to exposure to every 10 μg/m3 increment in air pollutant concentrations, including O3, NO2, PM10, and PM2.5. The meta-analysis revealed a significant association between the increased risk of AE-IPF in PM2.5, yielding RR 1.94 (95% CI 1.30–2.90; p = 0.001). Findings across all the included studies suggest that increased exposure to air pollutants may be linked to a range of health issues in individuals with ILDs.ConclusionA scarcity of available studies on the air pollutants and ILD relationship underscores the imperative for further comprehensive research in this domain. The available data suggest that reducing levels of PM2.5 in the atmosphere could potentially reduce AE frequency and severity in ILD patients.
COVID-19 vaccination willingness among people living with HIV in Shijiazhuang, China: a cross-sectional survey
Authors: Zhang Xihong , Zhan Haoting , Wang Lijing , Liu Yongmei , Guo Xinru , Li Chen , Li Xiaomeng , Li Beilei , Li Haolong , Li Yingxia , Chen Qian , Gao Huixia , Feng Fumin , Li Yongzhe , Dai Erhei 
Published: January 2024

ObjectivesThe COVID-19 pandemic imposed an enormous disease and economic burden worldwide. SARS-CoV-2 vaccination is essential to containing the pandemic. People living with HIV (PLWH) may be more vulnerable to severe COVID-19 outcomes; thus, understanding their vaccination willingness and influencing factors is helpful in developing targeted vaccination strategies.MethodsA cross-sectional study was conducted between 15 June and 30 August 2022 in Shijiazhuang, China. Variables included socio-demographic characteristics, health status characteristics, HIV-related characteristics, knowledge, and attitudes toward COVID-19 vaccination and COVID-19 vaccination status. Multivariable logistic regression was used to confirm factors associated with COVID-19 vaccination willingness among PLWH.ResultsA total of 1,428 PLWH were included, with a 90.48% willingness to receive the COVID-19 vaccination. PLWH were more unwilling to receive COVID-19 vaccination for those who were female or had a fair/poor health status, had an allergic history and comorbidities, were unconvinced and unsure about the effectiveness of vaccines, were unconvinced and unsure about the safety of vaccines, were convinced and unsure about whether COVID-19 vaccination would affect ART efficacy, or did not know at least a type of domestic COVID-19 vaccine. Approximately 93.00% of PLWH have received at least one dose of the COVID-19 vaccine among PLWH, and 213 PLWH (14.92%) reported at least one adverse reaction within 7 days.ConclusionIn conclusion, our study reported a relatively high willingness to receive the COVID-19 vaccination among PLWH in Shijiazhuang. However, a small number of PLWH still held hesitancy; thus, more tailored policies or guidelines from the government should be performed to enhance the COVID-19 vaccination rate among PLWH.