bluuebunny/crossref_metadata_2025_split huggingface dataset:
La carrera profesional en el ámbito de la Farmacia Comunitaria
Authors: Baena María Isabel , Del Arco Juan , Dago Ana , Miranda Francisco , Montagud Penadés Emilia , Treceño Lobato Carlos , Uriarte Juan , Vergniory Olatz , Vicedo Concepción , Virués Alberto , Román Alvarado Jaime 
Published: February 2025

Quienes ejercen en la Farmacia Comunitaria (FC), están acusando un escaso reconocimiento en su labor como profesionales de la salud, así como una escasez de expectativas de futuro y una ausencia de objetivos profesionales definidos, que afecta especialmente a quienes no ejercen como titulares, sino como trabajadores por cuenta ajena. Todo esto está provocando una desmotivación y un desapego hacia el trabajo en la FC, que afecta a quienes hoy trabajan en ese ámbito, pero también es percibido por las personas que aún no han iniciado su trayectoria profesional.
Para mantener un buen nivel en la atención farmacéutica y responder a las necesidades de la sociedad es imprescindible contar con profesionales cada día con mayor cualificación, pero es también esencial el reconocimiento y sobre todo la motivación con su trabajo en la FC.
El desarrollo profesional a través de la implementación de una carrera profesional ya ha sido contemplado por organismos internacionales como la Federación Farmacéutica Internacional y la Organización Mundial de la Salud que propugnan la creación y el apoyo a los grupos de profesionales competentes, apostando por la fuerza del trabajo en equipo para la consecución de los objetivos. La Agrupación Farmacéutica de la Unión Europea, en el documento elaborado sobre el futuro de la farmacia en un plan a 2030, manifiesta la necesidad de garantizar que la remuneración de los farmacéuticos/as comunitarios/as refleje correctamente su contribución a la mejora de la atención farmacéutica, reduciendo la carga sobre otros servicios de salud y garantizando la sostenibilidad de los sistemas sanitarios.
تدريبات بوسيلة (Kinetic link) وتأثيرها على القوة الخاصة وإنجاز عدائي 400م حرة تحت 18سنة
Authors: Dwmooa  Khawam Suleiman  , Hassan Nouri Tarish  
Published: February 2025

أن فعاليات السرعة من الفعاليات المشوقة التي لها متطلبات بدنية خاصة لأجل تحقيق الانجاز وتحقيق النتائج المتميزة والمنافسة دولياً، وذلك في الاهتمام بالألعاب الفردية ولاسيما الفئات العمرية من الناشئين في العاب القوى. وتعثير فعالية 400م من فعاليات الاركاض السريعة ذات المتطلبات الصعبة من ناحية القدرات البدنية الخاصة المطلوبة لتحقيق الإنجاز حيث يتطلب هـذا السـباق قـدراً هـائلاً مـن السرعة والتحمل والقوة بالإضافة إلى متطلبات قوة الإرادة والعزيمة ومواصلة الكفاح. ويتطلب الوصــول إلــى تحقيق أفضــل المستويات العالية فــي هــذا الســباق مســتوى عاليا مــن العناصــر والصــفات المهمــة للياقة البدنية ويتركز تدريب هـذه الفئـة مـن المتسابقين في وتحمل القوة المميزة بالسرعة عن طريق تمرينات Kinetic link)) تسـاعد تطوير العضلات املة للعدائن ورفـع قابليتهم البدنية ومـن ثـم يؤثر فـي تحسين الانجاز هـي تمرينات المقاومة بالحبال المطاطية وتعـد التدريبات بالوسيلة التدريبة من التدريب الحديث الساحة والميدان ويهدف تدريبات الى Kinetic link تنمية القوة العضلية من خلال تدريبات وتمرينات تحمل القوة والقوة المميزة بالسرعة وهذا النوع من التدريب يجبر جسم الرياضي على تحشيد الألياف العضلية السريعة وتحفيزها وهذه الخاصية مهمة جدأ لان الألياف العضلية السريعة تمتلك إمكانية النمو والتطور في تدريبات القوة. تكمن أهمية البحــث استخدام اسلوب التدريب الحديث بالمقاومات لتطوير القوة الخاصة وتأثيرها على الانجاز.
تأثير برنامج تدريبي مقترح لتطوير بعض القابليات البيوحركية وتركيز انزيمات الكبد في الدم وانجاز عدو200متر رجال
Authors: Fahem Abdul Wahid Easa  
Published: February 2025

يهدف البحث الى اعداد برنامج تدريبي مقترح لتطوير بعض القابليات البيو حركية وتركيز انزيمات الكبد في الدم وانجاز عدو 200 متر رجال , ومن خلال خبرة الباحث الميدانية لاحظ ان عدو 200 متر هبوط في المستوى البدني وعدم تقنين حمل التدريبات لان ايقاع وتناسق الخطوات يتأثر بالتعب , ولأهمية دور عملية انزيمات الكبد في الدم على انها مواد محفزة تساهم في سرعة الافعال , استخدم الباحث المنهج التجريبي وتحدد المجتمع لاعبي ستة اندية في العراق للموسم الرياضي 2024 , والبالغ عددهم (12) لاعب , وتم تقسيم العينة المجموعة التجريبية والمجموعة الضابطة وكل مجموعة (6) لاعب , واهم ما تم استنتاجه تفوق ملحوظ بين القياس القبلي والبعدي في متغيرات البحث للمجموعة التجريبية ولصالح القياس البعدي .
INVESTMENT RISKS AND RETURNS IN THREE-STAR HOTELS IN ENUGU CITY, SOUTH EAST NIGERIA
Authors: CAJETHAN CHIDI EZEMA  , CHUKWUNYERE OBINNA OKEAHIALAM  
Published: February 2025

The measurement of risks and returns are the variables for determining the performance of real estate investments. Risk is the probability of variation between actual and expected outcomes, while return is the profit realized from investment. Factors such as capital expenditure, operating expenditure, location, and scale are important variables in hotel investment. However, since this study concentrates on three-star hotels, scale was not considered as all hotels under consideration were of the same scale. This study analysed the risks and returns of investment in three-star hotels in Enugu city between 2015 and 2024 by calculating the Arithmetic Mean Return (AMR), Standard Deviation (SD), and Coefficient of Variation (COV) over the period. From a study population of fifty (50) three-star hotels in seven (7) locations in the city namely: Independence Layout, New Haven, Ogui Road, GRA, Trans Ekulu, Ebeano Tunnel, and Abakpa Nike, seven (7) hotels were selected,one from each location for the study. Data on the net annual income and capital values of the hotels between 2015 and 2024 were obtained through questionnaires sent to the general manager of each of the selected hotels. The results of the study found an inverse relationship between risks and returns among hotels with high capital values; risks were high while returns were lower. Hotels located in the city centre also had less returns due to higher expenditure and competition associated with central location. The study recommends that hoteliers should increase their returns and reduce risks by reducing their capital and operating expenditure.
COMPARATIVE OF SOCIO-DEMOGRAPHIC FACTORS THAT INFLUENCE NURSES’ COMMUNICATION DURING PREOPERATIVE PREPARATION OF SURGICAL PATIENTS IN SELECTED HOSPITAL IN OGBOMOSO
Authors: AYANTUNDE MONILOLA ALIRA  , AKANBI O.O  , AMAO P.O  
Published: February 2025

This study identifies the socio-demographic factors that influence nurses' communication and patients' satisfaction during the preoperative preparation of surgical patients in Ladoke Akintola University Teaching Hospital (LTH) and Bowen University Teaching Hospital (BUTH) in Ogbomoso. A cross sectional descriptive-correctional research design was employed for this study. A total of 170 surgical patients, which involved 100 and 70 patients at Ladoke Akintola University Teaching Hospital (LTH) and Bowen University Teaching Hospital (BUTH) in Ogbomoso were used respectively for this study and assessed using adopted questionnaires – Nurse Quality of Communication with Patient Questionnaire (NQCPQ) to assess the nurses’ communication and the La Monica Oberst Patient Satisfaction Scale (LOPSS) for patients’ satisfaction. Data obtained were analysed using Statistical Product and Service Solutions (SPSS) version 25. Descriptive analysis was expressed as Mean ± Standard deviation, using frequency Table, Multivariate linear regression and Pearson correlation were used for inferential statistics and the test of hypothesis, Statistical significance was determined at P<0.05. Findings showed high scores of nurse’s communication at LTH (105.51 ± 19.47) and BUTH (112.73 ± 20.00), indicate good quality of nurses’ communication. The total LOPSS score showed that moderate patients’ satisfactions across the hospitals with LTH (169.43 ± 35.32) and BUTH (177.89 ± 24.67). Multivariate linear regression analysis showed that at p<0.05, income level at LTH; marital status, religion, and knowing the name(s) of attending nurse(s) at BUTH significantly influenced nurse’s communication. Employment status and type of surgery at LTH; income level at BUTH; significantly influenced patient satisfaction (p<0.05). Nurse communication significantly correlates patient satisfaction in LTH. No significant correlation was found in BUTH, suggesting that context-specific factors may moderate the impact of nurse communication on patient satisfaction. However, the results in this research work is recommended for use in the health institutions.
CAUSES AND EFFECTS OF FARMERS-HERDSMEN CONFLICTS ON MAIZE PRODUCTION IN JIGAWA STATE, NIGERIA
Authors: ZAKARI, A.  , ABDULLAHI, A. G.  , MANUWA, A.  , ALKALI, K.  
Published: February 2025

The study assessed causes and effects of farmers-herdsmen conflicts on maize production in Jigawa State, Nigeria. A multi-stage sampling technique was used to select 180 maize farmers and herdsmen that were proportionately drawn from three (3) zones of the study area. Data were collected through the use of well-structured questionnaire and focused group discussion, data collected was analyzed using descriptive statistics. The result show that pooled percent 36.7% of respondents fell within the age bracket of 41-50 years. Majority pooled (96.7%) were males and 85.0% of them were married. The result revealed that pooled 36.7% the respondent had household size between 7-9 persons. Majority pooled (61.1%) of the respondent had non-formal education, while, a considerable number pooled (42.2%) of the respondents had farming/grazing experience. The results further revealed that major causes of farmers-herdsmen conflict were crops damage by cattle ( ), encroachment into cattle tracks , lack of access to water points , pollution of water points , indiscriminate bush burning , climate change , desertification and corruption . The results also shows that the major effects of conflicts on maize production were loss of maize crop 81.1%, reduction in crop yield 76.7%, displacement of farmers 94.4%, increased tension within the farming communities 90.0%, increased cost of production 100%, loss of farm inputs 76.7% and food insecurity 100%. The result further revealed the major institution involved in managing conflicts in which the effective ones were police , State government , Traditional rulers , Miyetti Allah cattle breeders association and community leaders . The study concluded that crop damage by cattle, encroachment into cattle tracks, lack of access to water points, pollution of water points and indiscriminate bush burning, cattle rustling, climate change, desertification and corruption were the major causes of conflict in the study area. The study therefore, recommended Government at all levels should explore better involvement of indigenous resource user groups in policies relating to natural resource management and utilization, Governments and communities should jointly cooperate to improve the security situation around the villages with a view to tackling the menace of cattle rustling.
Compressive strength in simple and colored concrete specimens in the city of Teófilo Otoni
Authors: Rocha Cibele Aparecida De Moraes , Sousa Gisele Monteiro de , Gomes Antonio Jorge de Lima 
Published: February 2025

This work deals with the comparison of the compressive strength in 4 concrete mixes and rupture of 36 specimens in the city of Teófilo Otoni. The first concrete trace was of the conventional type and the other three used colored additives in the percentages 3%, 5% and 6%. After curing, axial compression tests were performed on the tests at the ages of 7, 14 and 28 days. Through the disruptions, we can see that the concrete results that obtained results below expectations were samples with percentages of 5% and 6% pigments. Samples with 3% additive showed resistance close to theoretical values of 18, 25 and 40 MPa. The presence of biotite in the region's aggregates also may have contributed to the loss of strength of the concrete, due to its lamellar aspect, which demands more water and makes it difficult to incorporate the aggregates.
La gestion interculturelle des immigrants hautement qualifiés : une revue narrative
Authors: Ren Sijie , Morin Catherine 
Published: February 2025

Cette étude examine la gestion interculturelle (GI) des immigrants hautement qualifiés (IHQ) au sein des organisations, un sujet crucial en raison de l’augmentation significative des migrations depuis les années 1990 dans les pays occidentaux. L’objectif principal est de fournir une synthèse intégrée de l’état des connaissances actuelles sur les stratégies de GI concernant les IHQ et d’identifier les déterminants de ces stratégies. Pour ce faire, une revue narrative de la littérature a été réalisée en adoptant une approche analytique inductive. Une recherche documentaire quasi systématique dans quatre bases de données a conduit à la sélection de 30 articles pertinents pour l’analyse. Les résultats de l’étude ont permis d’identifier quatre stratégies organisationnelles principales de GI : l’interculturalisme, l’assimilation culturelle, l’inclusion multiculturelle et la synergie culturelle. Par ailleurs, l’étude souligne l’importance des stratégies individuelles d’acculturation adoptées par les IHQ. L’alignement entre les stratégies organisationnelles de GI et les stratégies individuelles d’acculturation est crucial pour une intégration efficace. Parallèlement, les déterminants de la GI ont été identifiés et classés selon trois catégories : individuel, de groupe et organisationnel. Ces facteurs interagissent pour influencer le processus d’intégration des IHQ et la réussite des stratégies de GI. Cette étude apporte une contribution en soulignant que la GI des IHQ est un sujet multidimensionnel et que son efficacité dépend des stratégies organisationnelles et des stratégies individuelles d’acculturation des IHQ. Elle souligne également l’importance pour les gestionnaires d’établir des attentes claires en matière de diversité culturelle et d’adopter des pratiques de gestion adaptées. Des recherches futures sont suggérées pour approfondir l’interdépendance entre les stratégies individuelles des IHQ et les stratégies organisationnelles de GI, ainsi que pour combiner les différents déterminants identifiés sur une période prolongée afin de mieux comprendre leur impact sur l’intégration des IHQ.
Assumer le retrait
Authors: Guatieri Quentin 
Published: February 2025

Cet article s’appuie sur une enquête effectuée dans le cadre d’une thèse doctorale en sociologie soutenue en décembre 2022. Celle-ci portait sur le rapport au travail, à la méritocratie, et à la réussite des jeunes ni aux études, ni en emploi, ni en formation (catégorisés comme NEET) au Québec. Parmi les 36 jeunes rencontrés provenant de différentes régions du Québec, 14 se plaçaient volontairement en retrait du marché du travail et du système éducatif au moment de la recherche. C’est sur ces derniers que cet article propose de se concentrer. En adoptant une approche compréhensive par des entretiens semi-directifs, nous apportons ainsi des éléments de réponse aux questions suivantes : Quels arguments et stratégies mobilisent-ils pour mettre à distance la pression sociale et institutionnelle à se « réintégrer » ? Quels sont les fondements et déterminants de cette sobriété volontaire ? Comment mettent-ils en pratique ce mode de vie alternatif ? Nous montrons que cette frugalité choisie et le sens donné à leur situation NEET assumée s’appuie sur deux pôles interconnectés : la résistance à la normativité du travail dans le parcours de vie, qui s’agence avec une redéfinition de l’utile ; et la mise à distance des modèles de réussite sociale et de mérite où la frugalité choisie s’inscrit dans un refus de jouer le jeu du « conditionnement » à accumuler et consommer. Nous rendons enfin compte des épreuves sociales et financières inhérentes à ce retrait choisi.
À rebours des institutions totales
Authors: Rigal Alexandre 
Published: February 2025

L’article esquisse un continuum des institutions de la sobriété, des plus totales aux plus partielles. Il prolonge la théorie des institutions élaborée par Erving Goffman uniquement à partir des formes et des effets socialisateurs des institutions totales. L’article construit, à rebours du pôle de l’institution totale, la notion d’institution partielle : ouverte, urbaine et qui socialise ponctuellement à des habitudes spécifiques. Ce continuum inédit offre un cadre d’analyse plus complet pour comparer les institutions de la sobriété et situer des cas précis.
C’est ce à quoi s’attelle la partie empirique de l’article, consacrée à deux ateliers d’autoréparation de vélo. Il s’agit de lieux qui promeuvent la sobriété en récupérant et en réparant des vélos. L’enquête dans les deux ateliers d’autoréparation de vélo repose sur 40 entretiens semi-directifs et un mois d’observation participante. Elle révèle que la forme des ateliers vélo permet :
1) l’apprentissage ponctuel d’habitudes spécifiques de la mécanique vélo,
2) la poursuite de la pratique quotidienne de la mécanique,
3) l’adoption généralisée de la sobriété.
Ces trois formes de socialisation montrent que les ateliers d’autoréparation de vélo cumulent les caractéristiques des institutions partielles de la sobriété (points 1 et 2) et des propriétés d’institutions plus totalisantes (point 3). Ce résultat permet de situer l’atelier d’autoréparation sur une ébauche de continuum des institutions de la sobriété.
En général, cette analyse d’un cas d’institution de la sobriété illustre comment le continuum goffmanien des institutions ouvre à des analyses comparatives et cumulatives des institutions de la sobriété.
Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy
Authors: Hull Vanessa L. , Wang Yan , McDonough Jennifer , Zhu Meina , Burns Travis , Al Ramel Najmah , Dehghani Ali , Guo Fuzheng , Pleasure David 
Published: January 2024

AbstractCanavan disease is a leukodystrophy caused by ASPA mutations that diminish oligodendroglial aspartoacylase activity, and is characterized by markedly elevated brain concentrations of the aspartoacylase substrate N‐acetyl‐l‐aspartate (NAA) and by astroglial and intramyelinic vacuolation. Astroglia express NaDC3 (encoded by SLC13A3), a sodium‐coupled transporter for NAA and other dicarboxylates. Astroglial conditional Slc13a3 deletion in aspartoacylase‐deficient Canavan disease model mice (“CD mice”) reversed brain NAA elevation and improved motor function. These results demonstrate that astroglial NaDC3 contributes to brain NAA elevation in CD mice, and suggest that suppressing astroglial NaDC3 activity would ameliorate human Canavan disease.
Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery
Authors: Zhou Qiaoxia , Liu Qiongliang , Wang Yan , Chen Jie , Schmid Otmar , Rehberg Markus , Yang Lin 
Published: January 2024

AbstractIntracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era of precision medicine that requires systematic knowledge of nano‐biological interactions from multidisciplinary perspectives. To this end, this review first provides an overview of membrane‐disruption methods such as electroporation, sonoporation, photoporation, microfluidic delivery, and microinjection with the merits of high‐throughput and enhanced efficiency for in vitro NDC delivery. The impact of NDC characteristics including particle size, shape, charge, hydrophobicity, and elasticity on cellular uptake are elaborated and several types of NDC systems aiming for hierarchical targeting and delivery in vivo are reviewed. Emerging in vitro or ex vivo human/animal‐derived pathophysiological models are further explored and highly recommended for use in NDC studies since they might mimic in vivo delivery features and fill the translational gaps from animals to humans. The exploration of modern microscopy techniques for precise nanoparticle (NP) tracking at the cellular, organ, and organismal levels informs the tailored development of NDCs for in vivo application and clinical translation. Overall, the review integrates the latest insights into smart nanosystem engineering, physiological models, imaging‐based validation tools, all directed towards enhancing the precise and efficient intracellular delivery of NDCs.
Medulloblastoma and other neoplasms in patients with heterozygous germline SUFU variants: A scoping review
Authors: Lee Stephanie G. , Evans Gareth , Stephen Maddie , Goren Rachel , Bondy Melissa , Goodman Steven 
Published: January 2024

AbstractIn 2002, heterozygous suppressor of fused variants (SUFU+/−) in the germline were described to have a tumor suppressor role in the development of pediatric medulloblastoma (MB). Other neoplasms associated with pathologic germline SUFU+/− variants have also been described among patients with basal cell nevus syndrome (BCNS; BCNS is also known as Gorlin syndrome, nevoid basal cell carcinoma [BCC] syndrome or Gorlin‐Goltz syndrome; OMIM 109400), an autosomal‐dominant cancer predisposition syndrome. The phenotype of patients with germline SUFU+/− variants is very poorly characterized due to a paucity of large studies with long‐term follow‐up. As such, there is a clinical need to better characterize the spectrum of neoplasms among patients with germline SUFU+/− variants so that clinicians can provide accurate counseling and optimize tumor surveillance strategies. The objective of this study is to perform a scoping review to map the evidence on the rate of medulloblastoma and to describe the spectrum of other neoplasms among patients with germline SUFU+/− variants. A review of all published literature in PubMed (MEDLINE), EMBASE, Cochrane, and Web of Science were searched from the beginning of each respective database until October 9, 2021. Studies of pediatric and adult patients with a confirmed germline SUFU+/− variant who were evaluated for the presence of any neoplasm (benign or malignant) were included. There were 176 patients (N = 30 studies) identified with a confirmed germline SUFU+/− variant who met inclusion criteria. Data were extracted from two cohort studies, two case‐control studies, 18 case series, and eight case reports. The median age at diagnosis of a germline SUFU+/− variant was 4.5 years where 44.4% identified as female and 13.4% of variants were de novo. There were 34 different neoplasms (benign and malignant) documented among patients with confirmed germline SUFU+/− variants, and the most common were medulloblastoma (N = 59 patients), BCC (N = 21 patients), and meningioma (N = 19 patients). The median age at medulloblastoma diagnosis was 1.42 years (range 0.083–3; interquartile range 1.2). When data were available for these three most frequent neoplasms (N = 95 patients), 31 patients (32.6%) had neither MB, BCC nor meningioma; 51 patients (53.7%) had one of medulloblastoma or BCC or meningioma; eight patients (8.4%) had two of medulloblastoma or BCC or meningioma, and five patients (5.3%) had medulloblastoma and BCC and meningioma. This is the first study to synthesize the data on the frequency and spectrum of neoplasms specifically among patients with a confirmed germline SUFU+/− variant. This scoping review is a necessary step forward in optimizing evidence‐based tumor surveillance strategies for medulloblastoma and estimating the risk of other neoplasms that could impact patient outcomes.