bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motives for desiring children among individuals of different sexual–romantic orientations: a cross-sectional study
Authors: Widmer R. , Knabben L. , Bitterlich N. , von Wolff M. , Stute Petra 
Published: December 2023

Abstract
Purpose
Little is known about the reasoning behind the desire to have children in non-heterosexual individuals. This study compares the motives of different sexual–romantic orientations and their preferred ways of fulfilling this desire.

Methods
This was a monocentric cross-sectional study. Subjects were recruited via social media, personal contacts and queer organisations in Switzerland.
An anonymous questionnaire comprised general questions about the participant's background, a validated survey about the desire to have children and additional non-validated questions addressing the impact of sexual–romantic orientation on the desire to have children. The inclusion criteria were adults without children and a completed questionnaire.

Results
Of 837 participants, 642 were included in the study. Four groups of sexual–romantic orientations consisted of more than 35 participants: bisexual–biromantic (n = 38), heterosexual–heteroromantic (n = 230), homosexual–homoromantic (n = 159) and pansexual–panromantic (n = 55).
Subgroups with a positive wish for a child rated all motives in the same order and with minimal numeric difference. The most important aspect seemed to be emotional involvement. Non-heterosexual–heteroromantic showed concerns about adverse reactions regarding their wish for a child. All orientations hoped for a biological child.

Conclusion
Our findings about bi-, hetero-, homo- and pansexual people and their motives for a desire to have children agree with the existing literature about hetero, homo and bisexual. The impact of the fear of adverse reaction and discrimination has been discussed before and is supported by our data. We suggest better support before and during the realization of the wish for a child as well as support for non-traditional aspiring parents.
Evaluation status of current and emerging minimally invasive robotic surgical platforms
Authors: Boal M. , Di Girasole C. Giovene , Tesfai F. , Morrison T. E. M. , Higgs S. , Ahmad J. , Arezzo A. , Francis N. 
Published: December 2023

Abstract
Background
The rapid adoption of robotics within minimally invasive surgical specialties has also seen an explosion of new technology including multi- and single port, natural orifice transluminal endoscopic surgery (NOTES), endoluminal and “on-demand” platforms. This review aims to evaluate the validation status of current and emerging MIS robotic platforms, using the IDEAL Framework.

Methods
A scoping review exploring robotic minimally invasive surgical devices, technology and systems in use or being developed was performed, including general surgery, gynaecology, urology and cardiothoracics. Systems operating purely outside the abdomen or thorax and endoluminal or natural orifice platforms were excluded. PubMed, Google Scholar, journal reports and information from the public domain were collected. Each company was approached via email for a virtual interview to discover more about the systems and to quality check data. The IDEAL Framework is an internationally accepted tool to evaluate novel surgical technology, consisting of four stages: idea, development/exploration, assessment, and surveillance. An IDEAL stage, synonymous with validation status in this review, was assigned by reviewing the published literature.

Results
21 companies with 23 different robotic platforms were identified for data collection, 13 with national and/or international regulatory approval. Of the 17 multiport systems, 1 is fully evaluated at stage 4, 2 are stage 3, 6 stage 2b, 2 at stage 2a, 2 stage 1, and 4 at the pre-IDEAL stage 0. Of the 6 single-port systems none have been fully evaluated with 1 at stage 3, 3 at stage 1 and 2 at stage 0.

Conclusions
The majority of existing robotic platforms are currently at the preclinical to developmental and exploratory stage of evaluation. Using the IDEAL framework will ensure that emerging robotic platforms are fully evaluated with long-term data, to inform the surgical workforce and ensure patient safety.

Graphical abstract
Experimental determination of friction at the interface of a sand-based, seismically isolated foundation
Authors: Sezer Yusuf M. , Diambra Andrea , Ge Borui , Dietz Matt , Alexander Nicholas A. , Sextos Anastasios G. 
Published: December 2023

AbstractThis paper describes the results of an experimental investigation on the coefficient of friction at the interface of a PVC–sand–PVC layer that is utilised as part of a low-cost geotechnical seismic isolation devised to be used in low-income countries. The PVC–sand–PVC configuration consists of two smooth PVC surfaces enclosing a single layer of sand grains, with surface densities between 0.5 kg/m2 and 3 kg/m2, which aim to facilitate relative sliding at friction resistance between 0.15 and 0.30 depending on the design acceleration, by acting like “non-perfectly rounded ball bearings”. The latter isolation method has been extensively studied both numerically and experimentally by means of large-scale testing at the shaking table of the EQUALS Earthquake Laboratory of the University of Bristol. However, in the light of the construction of the first building worldwide to be designed and constructed in Nepal with the particular low-cost PVC–sand–PVC sliding interface, it was deemed necessary to reliably assess the mean and dispersion of the coefficient of friction as a function of vertical pressure, sand density and degree of saturation. The results of the tests performed using an improved direct shear apparatus are presented herein using sand samples and PVC sheets that were locally resourced in Nepal to be used in construction. The results indicate that the variation of friction is reasonably low and in any case within the desirable range, irrespectively of the parameters examined, thus establishing confidence to the forthcoming design of the novel isolated building.
Combined effects of microplastics and temperature on the competition between Brachionus havanaensis and Brachionus calyciflorus (Rotifera)
Authors: Reyes-Santillán Mayra Carolina , Nandini S. , Sarma S. S. S. 
Published: December 2023

AbstractAquatic organisms are constantly exposed to effluents which often contain microplastics. Microplastics adversely affect aquatic organisms as a result of mechanical damage during ingestion or intoxication by chemicals adsorbed on the microplastics. Sub-optimal temperatures may acerbate the adverse effects of microplastics on aquatic biota. Brachionid rotifers, such as Brachionus havanaensis and Brachionus calyciflorus, are common in tropical freshwaters. They are generalist filter feeders capable of consuming microplastic particles of a wide size range 0.05 to 40 µm, which can eventually affect growth and competitive interactions among species. Here, we evaluated the effect of 30 µm beads of polystyrene microplastics at 10 and 20 mg l−1 on the population growth and competition of B. havanaensis and B. calyciflorus at 20 and 25 °C using 0.5 × 106 cells ml−1Chlorella vulgaris as food. Population growth decreased in treatments with microplastics at both temperatures as compared to the controls. The population growth rates ranged between 0.21 and 0.38 d−1 for B. calyciflorus, and between 0.27 and 0.48 d−1 for B. havanaensis. The presence of the competing species significantly lowered the population growth rate for B. calyciflorus but not for B. havanaensis. On the other hand, while the presence of the microplastics had little impact on the population growth rate of B. calyciflorus in the presence of the competitor, the reverse was true for B. havanaensis, especially at 20 °C. Our results show that the presence of microplastics may affect rotifer community structure in natural water bodies.
IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells
Authors: Chen Yifei , Zhu Miaojuan , Hu Jiahao , He Shaojun , Li Shuhua , Liu Bing , Yang Jiong 
Published: December 2023

AbstractInterleukin-27 receptor (IL-27R) is expressed in a variety of immune cells and structural cells, including dendritic cells. The mechanism of IL-27 in asthma has not been fully elucidated. This study aimed to examine whether IL-27 regulated the CD39/ATP axis of dendritic cells in asthma. Our results showed that in ovalbumin (OVA)-induced asthma mouse model, IL-27Rα−/− asthmatic mice showed increased airway resistance, increased infiltration of inflammatory cells in lung tissue, proliferation of goblet cells, enhanced expression of Muc5 AC around airway epithelium, increased total number of cells and eosinophils, increased levels of total IgE, OVA-IgE, IL-4, IL-5, IL-13 and IL-17 A, and increased expression of transcription factors GATA-3 and RORγt in lung tissue. The expression of CD39 mRNA and protein in the lung tissue of IL-27Rα−/− asthmatic mice decreased, and the expression of NLRP3, ASC and Caspase-1 in NLRP3 inflammasome components increased. The concentration of ATP was significantly increased compared with WT asthmatic mice. In vitro experiments showed that the expression of CD39 in lung dendritic cells of IL-27Rα−/− asthmatic mice decreased, while the expression of NLRP3 inflammasome components NLRP3, ASC and Caspase-1 increased. These findings indicate that IL-27 directly and indirectly regulates immunoinflammatory responses in asthma by acting on dendritic cells CD39/ATP Axis.
Technical science capital in relation to how students manage within higher technical education
Authors: Engström Susanne , Blom Johanna 
Published: December 2023

AbstractThis study aims to understand how students manage higher technical education and contribute to research on institutional culture, STEM education, and students’ educational strategies by identifying patterns of how students navigate within one university’s engineering education. To achieve this, we define and use the concept of technical science capital and habitus reconstruction. We collected data through a survey sent to engineering students who have followed an engineering program’s intended linear progression and those who have taken a ‘detour’ within the same cohort at one specific Swedish university. The survey had a high number of qualitative questions, including free text answers that captured students’ narratives. The results indicate that having a large amount of technical science capital alone is not enough for students to be successful in their studies. The university culture has its own structure, which can be intolerant. Within this culture, specific social skills and experiences are desirable, which provides students from a particular background with a greater opportunity for success. Despite possessing high technical science capital, students from other social groups or cultures face challenges. We discuss various measures that could make higher technical education more engaging. This study is limited to one Swedish university, and future studies could include a broader sample that represents several universities.
A backup plan for life? Alternative Life paths facilitate disengagement in an action crisis
Authors: Mlynski Christopher , Mueller Swantje , Napolitano Christopher M. , Job Veronika 
Published: December 2023

AbstractWhile there is anecdotal evidence and some scientific support for the value of having multiple paths to reach one’s life goals, recent work concerning backup plans argues that their mere availability undermines commitment to and performance in the originally chosen path. In this paper, we evaluated this phenomenon amongst college students (N = 345) entering their first term with an already available family-based alternative life path. As expected, entering into college with an available family-based alternative life path led to a decrease in study commitment over the first semester and indirectly predicted lower end-of-semester grades through this reduction in commitment. However, results indicate that this only occurred when students reported experiencing an action crisis at the end of their first semester. If students did not report having an action crisis, an available family-based alternative life path did not influence study commitment and predicted a higher end-of-semester GPA. Ultimately, findings highlight the major role action crisis plays in the influence an alternative life path has on path trajectory.
Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Authors: Perlikowska Renata , Silva Joana , Alves Celso , Susano Patricia , Zakłos-Szyda Małgorzata , Skibska Agnieszka , Adamska-Bartłomiejczyk Anna , Wtorek Karol , do Rego Jean-Claude , do Rego Jean-Luc , Kluczyk Alicja , Pedrosa Rui 
Published: December 2023

AbstractNaturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OHDA) injury model of human neuroblastoma SH-SY5Y and lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The determination of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), Caspase-3 activity, lipid peroxidation and nitric oxide (NO) production allowed us to determine the effects of peptides on hallmarks related to Parkinson’s Disease (PD) and inflammation. Additionally, we investigated the impact of R-6 analogs on serine-threonine kinase (also known as protein kinase B, AKT) and mammalian target of rapamycin (mTOR) activation. The treatment with analogs 3 (Tyr-Inp-Leu-Asp-Leu-Phe-OH), 5 (Dmt-Inp-Leu-Asp-Leu-Phe-OH) and 7 (Tyr-Inp-Leu-Asp-Leu-Phe-NH2) most effectively prevented neuronal death via attenuation of ROS, mitochondrial dysfunction and Caspase-3 activity. Peptides 5 and 7 significantly increased the protein expression of the phosphorylated-AKT (p-AKT) and phosphorylated-mTOR (p-mTOR). Additionally, selected analogs could also ameliorate LPS-mediated inflammation in macrophages via inhibition of intracellular generation of ROS and NO production. Our findings suggest that R-6 analogs exert protective effects, possibly related to an anti-oxidation mechanism in in vitro model of PD. The data shows that the most potent peptides can inhibit 6-OHDA injury by activating the PI3-K/AKT/mTOR pathway, thus playing a neuroprotective role and may provide a rational and robust approach in the design of new therapeutics or even functional foods.
Climate (im)mobilities in the Eastern Hindu Kush: The case of Lotkuh Valley, Pakistan
Authors: Khan Saeed A. , Doevenspeck Martin , Sass Oliver 
Published: December 2023

AbstractThe relationship between climate, environment, and human mobility is complex as (im)mobility outcomes are influenced by multiple socioeconomic, political, and environmental factors. The current debate is focused on migration as an adaptation strategy in the face of climate change but largely ignores the immobility aspect, particularly in the Eastern Hindu Kush where mountain livelihoods are strongly dependent on local environmental conditions. In this study, we examine the interrelations between climate change and the environment as drivers of human mobility and immobility in the mountain communities of Lotkuh valley, Chitral, in north Pakistan. We employed a mixed methods approach grounded in migration theory to describe the relationship between climate change, environment, and (im)mobility outcomes. The study reveals that climate (im)mobilities are the outcome of a complex interplay between climate change, extreme events, and local livelihoods. The primary drivers of (im)mobility are socioeconomic factors. Forced displacement is driven by a multitude of extreme events in the area. Three critical aspects of livelihoods—land resources, crop productivity, and livestock farming—are identified as significant factors influencing mobility and immobility outcomes. Recurring extreme events such as floods and landslides exacerbate soil erosion and the loss of fertile farmlands, leading to food insecurity and compelling households to resort to labor migration as an adaptation strategy. Conversely, for households facing severe income stress and depleted economic assets, immobility becomes the only viable option due to insufficient resources for migration. Moreover, the study reveals that some households adopt a mixed strategy by sending select members to other areas while others remain in their places of origin to sustain their livelihoods. The study has implications for policymakers, government, and development organizations in the region suggesting sustainable livelihoods and adaptation measures to address the specific challenges faced by mountain communities in the Lotkuh valley and the wider region.
Re-viewing entrepreneurial universities through alumni engagement
Authors: Politis Diamanto , Aaboen Lise , Eide Ann Elida , Haneberg Dag Håkon 
Published: December 2023

AbstractThe paper contributes to re-viewing entrepreneurial universities by expanding the understanding of the role and impact of alumni engagement in this context. Embedded in a stakeholder theory perspective, we develop and test a framework that identifies social, behavioural, cognitive and affective drivers of alumni engagement. We conducted statistical analyses to test hypotheses on a sample of 493 entrepreneurship graduates from Venture Creation Programs (VCP) at three major universities in Scandinavia. Our theorising and findings suggest that alumni engagement is multifaceted—encompassing providing and connecting functions. Furthermore, the analysis suggests social, behavioural and affective drivers to accelerate alumni engagement. Future studies of entrepreneurial universities should focus more specifically on how entrepreneurship education and university managers may prepare students for becoming engaged alumni.
Personal agency among students from low socio-economic backgrounds: An examination of student profiles, perceived teaching support, and achievement
Authors: Collie Rebecca J. , Martin Andrew J. , Flesken Anaïd , McCourt Brianna 
Published: December 2023

AbstractPersonal academic agency—the thoughts, actions, and emotions that impact individual functioning at school—is central for academic success. On average, students from low socio-economic status (low-SES) backgrounds report lower levels of personal academic agency than their more advantaged peers, but there are also many who achieve academic success. Identifying different personal academic agency profiles among students from low-SES backgrounds may assist in targeting efforts to boost these factors within that population—and to identify students who are faring well, as well as those who might require additional support. This study examined five factors of personal academic agency (perceived competence, school belonging, perseverance, academic buoyancy, and conduct problems) among 20,125 secondary school students from low-SES backgrounds at 421 Australian schools. We identified profiles of students that vary in patterns of personal academic agency, and examined teaching support predictors and achievement differences associated with profile membership. Latent profile analysis revealed five student profiles: Vulnerable (9% of sample), Resigned (27%), Precarious (28%), Average (32%), and Flourishing (14%) profiles. Students’ perceptions of teaching support predicted membership in more adaptive profiles (i.e., Average and Flourishing profiles)—with the most consistent teaching support predictors being emotional support, classroom management, and instructional relevance. In addition, the Flourishing profile displayed the highest achievement.
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
Authors: Kim Joonyoung , Donnelly David J. , Tran Tritin , Pena Adrienne , Shorts Andrea Olga , Petrone Thomas V. , Zhang Yunhui , Boy Kenneth M. , Scola Paul M. , Tenney Daniel J. , Poss Michael A. , Soars Matthew G. , Bonacorsi Samuel J. , Cole Erin L. , Grootendorst Diederik J. , Chow Patrick L. , Meanwell Nicholas A. , Du Shuyan 
Published: December 2023

Abstract
Purpose
In cancer immunotherapy, the blockade of the interaction between programmed death-1 and its ligand (PD-1:PD-L1) has proven to be one of the most promising strategies. However, as mechanisms of resistance to PD-1/PD-L1 inhibition include variability in tumor cell PD-L1 expression in addition to standard tumor biopsy PD-L1 immunohistochemistry (IHC), a comprehensive and quantitative approach for measuring PD-L1 expression is required. Herein, we report the development and characterization of an 18F-PD-L1-binding macrocyclic peptide as a PET tracer for the comprehensive evaluation of tumor PD-L1 expression in cancer patients.

Procedures
18F-BMS-986229 was characterized for PD-L1 expression assessment by autoradiography or PET imaging. 18F-BMS-986229 was utilized to evaluate tumor PD-L1 target engagement in competition with a macrocyclic peptide inhibitor of PD-L1 (BMS-986189) over a range of doses using PET imaging. A whole-body radiation dosimetry study of 18F-BMS-986229 in healthy non-human primates (NHPs) was performed.

Results
In vitro autoradiography showed an 8:1 binding ratio in L2987(PD-L1 +) vs. HT-29 (PD-L1-) tumors, more than 90% of which could be blocked with 1 nM of BMS-986189. Ex vivo autoradiography showed that 18F-BMS-986229 detection was penetrant over a series of sections spanning the entire L2987 tumor. In vivo PET imaging in mice demonstrated a 5:1 tracer uptake ratio (at 90–100 min after tracer administration) in L2987 vs. HT-29 tumors and demonstrated 83%-93% specific binding of BMS-986189 within those dose ranges. In a healthy NHP dosimetry study, the resultant whole-body effective dose was 0.025 mSv/MBq.

Conclusion
18F-BMS-986229 has been preclinically characterized and exhibits high target specificity, low background uptake, and a short blood half-life supportive of same day imaging in the clinic. As the PET tracer, 18F-BMS-986229 shows promise in the quantification of PD-L1 expression, and its use in monitoring longitudinal changes in patients may provide insights into PD-1:PD-L1 immuno-therapy treatment outcomes.