Abstract C094: Real-world clinicopathologic characteristics of young Hispanic patients with lung cancer
Authors: Manoharan Aysswarya , Edwards Kyle , Esquives Blanca Noriega , Abbar Nora El , Ramos Leana , Parikh Nitin , Kareff Samuel , Rodriguez Estelamari , Olazagasti Coral 
Published: December 2023

Abstract
BACKGROUND Hispanics are the largest growing minority in the US. Furthermore, lung cancer remains the cancer with the highest mortality among Hispanic patients. Research has suggested that rates of lung cancer among younger patients have been increasing. Despite this, very little is known about Hispanic patients who were diagnosed with lung cancer at a young age. METHODS A total of 135 patients (65 non-Hispanic [NH] and 70 Hispanic) treated at the University of Miami from 2012-2021 with a diagnosis of lung cancer under the age of 45 were included. Demographic and clinicopathologic characteristics were analyzed. RESULTS The median age at diagnosis for Hispanic and non-Hispanic (NH) was 38yrs vs 40yrs, respectively (p=0.09). A total of 59% of Hispanics were female and 56% of all Hispanics had history of tobacco use (p=0.41). Of the NH, 56% were female and 60% endorsed a history of smoking tobacco. The Hispanic patients were 23% Cuban, 3% Puerto Rican, 16% South/Central American, and 58% not specified. The average time to surgery from a positive biopsy was 23 days for Hispanic and 15 days for NH (p=0.44). The average time to chemotherapy initiation was 35 and 41 days for Hispanics vs NH (p=0.39). The most common histology for both groups was adenocarcinoma, accounting for 60% and 53.8% for Hispanics and NH, respectively. Hispanics have higher trends of metastatic disease at diagnosis (63% vs 58% for NH), although rates did not reach statistical significance (p=0.16). Among those with next generation sequencing results, 60.5% of Hispanic patients had an actionable mutation compared to only 50% of NH patients with the presence of an actionable mutation (p=0.37). CONCLUSION To our knowledge, this is the largest cohort of young Hispanics with lung cancer to be described in the U.S. Despite no statistically significant findings, our single institution analysis did reveal some interesting trends. Our data revealed that the majority of patients in both groups were female, which differs from the incidence of lung cancer in the older population of more male predominance. In our sample, a higher percentage of Hispanic patients were diagnosed at advanced stages of lung cancer. Larger prospective studies will be of interest to better understand the disparities that may exist between different ethnicities among younger patients with lung cancer.
Citation Format: Aysswarya Manoharan, Kyle Edwards, Blanca Noriega Esquives, Nora El Abbar, Leana Ramos, Nitin Parikh, Samuel Kareff, Estelamari Rodriguez, Coral Olazagasti. Real-world clinicopathologic characteristics of young Hispanic patients with lung cancer [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C094.