bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pork Intake and Cardiovascular Diseases: A Mendelian Randomization Study
Authors: Zhao yibin , Xu Fu 
Published: October 2023

Abstract

Background: A few of cohort studies declared an converse association between pork intake and cardiovascular diseases, but the causal relationship is ambiguous.
Objective: To evaluate the causal relationship between pork intake, and cardiovascular diseases and cardiovascular biomarkers.
Methods: We adopted a two-sample Mendelian randomization (MR) analysis, based on inverse variance weighting as the dominate method. Besides, we performed sensitivity analyses, repeated analyses, and instrumental variable strength assessment for certifying the results reliability.
Results：We found that increased pork intake per standard deviation could add the risk of transient ischemic attack (odds ratio (OR) =5.63; 95% confidence interval (CI), 1.71–18.59; p= 0.004), and we also observed suggested proof of a converse association between pork intake and myocardial infarction. No associations were discovered for hypertension, atrial fibrillation, coronary heart disease, ischemic stroke, heart failure, type 2 diabetes, pulmonary embolism and peripheral artery disease. There is proof that pork intake is positively correlated with adiponectin. Body mass index, waist circumference, blood pressure, inflammation biomarkers, total cholesterol, triglycerides, HDL, LDL, fasting glucose were not affected by pork intake.
Conclusions: A causal connection between pork intake and the risk of transient ischemic attack is indicated in our research. Any convincing evidence had been failed to find to suggest that pork intake is causally related to the risk of other cardiovascular diseases and their biomarkers.
Preparation and adsorption properties of cotton linters and coal- gangue-based cellulose/SiO 2 composite aerogels
Authors: Hu Canming , Yang Xupeng , An Xiongfei , Chen Xiaojiao , Ding Chengli 
Published: October 2023

Abstract
High-value comprehensive utilization of coal gangue solid waste, reducing synthesis cost and environmental hazards has become an important research direction for green development. In this study, acid-alkali treated coal gangue was used as the silica source, and abundant cotton short staple in Xinjiang was used as the raw material of aerogel. Cellulose/SiO2 composite aerogels were prepared by sol-gel method using N-N methylenebisacrylamide (MBA) as cross-linking agent and hydrochloric acid (HCl) as catalyst. The samples were characterized and analyzed by XRD, SEM, FT-IR, XPS, EDS, BET, and mechanical property tests. The results show that the composites exhibit low density and high porosity. The density ranges from 0.177–0.371 g/cm− 3 with a high porosity of 88.7%. SEM and BET results showed that the composites showed a three-dimensional mesh structure, and the specific surface area was as high as 325.742 m2/g, with a pore size of 21.997nm, which is a mesoporous material. The adsorption performance of the composite aerogel was tested by choosing the dye methylene blue (MB) to simulate wastewater, and the results showed that the adsorption amount of MB was 81.3 mg/g, and the adsorption amount showed a tendency of increasing first and then decreasing with the increase of SiO2. It still showed good adsorption after 5 cycles of adsorption experiments. Therefore, the results of this study provide a good application prospect for composite aerogels and a theoretical basis for the development of low-cost novel advanced materials.
Co-developing journey maps with older adult patients with cancer to contextualize and incorporate patient- reported data into practice
Authors: Kwon Jae-Yung , Moynihan Melissa , Wolff Angela C. , Irlbacher Geraldine , Joseph Amanda L. , Wilson Lorraine , Horlock Hilary , Hung Lillian , Lambert Leah K. , Sawatzky Richard 
Published: October 2023

Abstract

PurposeSupporting clinicians in contextualizing PROM data to better understand patients’ health stories could lead to improved person-centred cancer care. Integrating PROMs into journey maps is one way to assist clinicians in making sense of PROMs data. This project co-developed PROM-informed journey maps in partnership with older adults who have cancer and received radiation therapy as a knowledge translation strategy to support clinicians in effectively using PROMs in their practice.MethodsSix older adults who received radiation therapy as part of their cancer treatment participated in individual semi-structured interviews to co-develop journey maps. Participants were asked about their health care experiences and well-being with a focus on their feelings, tasks, and influences during four phases of their cancer journey: pre-diagnosis, diagnosis, treatment, and post-treatment. Reflecting on their experiences, participants completed the well-being item from the Edmonton Symptom Assessment System revised (ESAS-r) questionnaire for each phase. This information was used in the context of journey maps to understand how and why participants’ well-being scores changed.ResultsAcross the six journey maps, several opportunities to discuss and address older adult cancer patients’ well-being were identified from the PROM data. This included providing education on early detection and preventing recurrence of cancer, as well as having conversations throughout the cancer journey to address patients’ well-being and mental health needs over time.ConclusionAs a knowledge translation tool, journey maps have the potential to support clinicians in using PROMs data to contextualize patient experiences and better understand their health stories and changing needs during their cancer care trajectory.
Revealing new bacterial functions in the plant rhizoplane
Authors: Saati-Santamaría Zaki , González-Dominici Lihuén Iraí , Jiménez-Gómez Alejandro , Morais Daniel , Tláskal Vojtěch , Benada Oldřich , Qi Li , Sheng Yang , Rivas Raúl , Baldrian Petr , García-Fraile Paula 
Published: October 2023

Abstract
Background Microorganisms play important ecological roles during interactions with plants. Although some microorganisms promote plant performance and are applied as biofertilizers, the molecular cross-talk of bacteria and plants is not fully understood. We aim to reveal which bacterial genes are tightly associated with the adaptation to the plant host by merging the outcomes of RNA-Seq data of a bacterium colonizing roots and comparative genomics analyses.Results Here, we show the expression of genes in a plant growth-promoting Pseudomonas strain interacting with plant roots. Our findings highlight that many of the upregulated genes have not been previously associated with this interaction. The occurrence of 184 of the upregulated bacterial genes in the interaction was higher in Pseudomonas isolates from plants compared to bacteria from other habitats, such as soils, animals or water. We argue that these genes may play relevant biological roles in this host, but only a few have been previously shown to be associated with plant-bacteria interactions. One of these genes is the yafL gene, encoding a cysteine peptidase with an NlpC/P60 hydrolytic domain, for which we demonstrate its involvement in bacterial plant growth promotion through the comparison of a wild-type bacterium with a yafL knockout strain.Conclusions Microbial plant growth promotion is a complex process with potential involvement of numerous bacterial genes, many of which still await characterization. By integrating the outcomes from in vivo RNA-Seq experiments and comparative genomic analyses, we have revealed several plant-associated genes and functions. Moreover, we have experimentally demonstrated the role of one of these genes in plant growth promotion.
Multi-omic data and modelling analyses reveal that HAP complex integrates TORC1/PKA and SNF1 signalling pathways
Authors: Henriques David , Moimenta Artai , Balsa-Canto Eva 
Published: October 2023

Abstract
Crabtree-positive yeast species such as Saccharomyces cerevisiae produce most of their ATP through alcoholic fermentation in the presence of oxygen and abundant glucose. This seemingly inefficient growth strategy leads to substantial industrial losses. Thus, many research efforts have focused on formulating hypotheses and computational growth models to explain this phenomenon, but have not given much attention to the development of dynamic models that integrate growth and mechanistic regulation of protein expression. From a regulatory point of view, this phenotype implies rapid growth and repression of respiratory genes. When intracellular glucose levels are low, SNF1 and the HAP complex control respiration activation. Among the proteins in the HAP complex, only HAP4 is believed not to be constitutively expressed and is considered the signal transduction element in this pathway. The transcription of genes from the translation machinery is primarily associated with TORC1 and PKA. Here, we have formulated an integrated dynamic model of respiro-fermentative growth and regulation of S. cerevisiae using two proteomic data sets obtained during diauxic shift experiments. After analysing the model and data, we concluded that HAP5 is also up-regulated in response to decreasing glucose levels, and this regulation occurs downstream of the TORC1 and PKA pathways. These two hypotheses were validated using independent transcriptomics data sets. Given its architecture, we postulate that the HAP complex integrates information from the PKA/TORC1 and SNF1 pathways. Our findings provide valuable information on the evolution of the Crabtree effect and can help design strategies to reduce its impact.
The miR-181b, miR-155 and miR-454 Expression in ctRNA in the Peripheral Blood Circulation of the Patients with Uveal Malignant Melanoma
Authors: Hassani Masoumeh , Doğan Tunay , Akdeniz Demet , Tuncer Samuray , Yazıcı Hülya 
Published: October 2023

Abstract

The Discovery of new non-invasive biomarkers in malignant melanoma is essential for the early diagnosis and follow-up of the disease. The aim of the study is to identify the expression levels of miR-181b and miR-155 and miR-454 in the ctRNA of serum/plasma samples of patients, and compare the differences with the healthy controls. The expression levels of miR-181b, miR-155, and miR-454 were examined and compared with the healthy controls on the cell-free RNA (ctRNA) extracted from the peripheral blood serum/plasma samples of the 72 uveal malignant melanoma patients, and 72 healthy individuals. The analysis showed that the expression level of the miR-181b has increased 9.25 fold, and expression level of miR-155 has increased 6.67 fold, and miR-454 expression level has increased 4.14 fold in the patient group compared with the levels in the control group. We found that the expression levels of the three miRNAs were statistically significant in patients compared with the expression levels in the healthy control group. The statistical evaluations between miRNA expression levels and clinical data showed that miR-155 had significant association with radiation therapy, and miR-454 showed a significant association with smoking and alcohol use. The significantly higher expression levels of miR-181b, miR-155 and miR-454 in plasma/serum RNAs in the peripheral bloodstream of uveal melanoma patients compared with the levels in the control group suggest that these molecules can be evaluated both as the drug targets for the early diagnosis and follow-up of the disease.
MoVN-coated MoNi4 -MoO2 nanorods as a bifunctional electrode for Electrochemical water splitting
Authors: Kumaran Yamini , Gherasoiu Iulian , Thandavarayan Maiyalagan , Efstathiadis Haralabos 
Published: October 2023

Abstract
MoVN/MoNi4-MoO3 nanorods are synthesized using a two-step fabrication process consisting of the hydrothermal method and DC(V) and RF(Mo) magnetron co-sputtering technique. The resulting electrode exhibits a high surface area, that together with its intrinsic catalytic activity, achieves a synergistic effect, thereby improving the reaction kinetics of overall water splitting. The performance of the electrodes was tested in 1M KOH solution, to understand the reaction mechanisms and catalytic efficiency of both the half-cell reactions (Hydrogen Evolution Reaction and Oxygen Evolution Reaction). The electrodes performed exceptionally well with overpotentials of only 14 mV and 244 mV at 10 mA/cm2 for HER and OER respectively compared to other electrode materials described previously in literature. Further, the stability of the electrodes was tested for 12 hours showing a negligible change in current density for both HER and OER reactions. Overall electrolysis was performed for 12 hours with the best electrode MoVN/MoNi4-MoO2 needing only 1.56 V to reach 10 mA/cm2. Material characterization using X-ray Diffraction, Scanning Electron Microscopy, and Transmission Electron Microscopy were carried out for crystal structure and morphological analysis. X-ray photoelectron spectroscopy was performed to understand the nature of the surface species of the best-performing electrode and to study the degradation effects after electrolysis. Hence, this work uncovers the outstanding properties of the MoVN/MoNi4-MoO2 electrode material with relatively high electrochemical surface area, low overpotential, and negligible degradation which could provide a competitive path to the fabrication of low-cost and highly effective electrodes for application in commercial electrolyzers.
Survival impact of pathologic features after salvage lung resection following definitive chemoradiotherapy or systemic therapy for initially unresectable lung cancer
Authors: Oka Naoyuki , Hishida Tomoyuki , Kaseda Kaoru , Suzuki Yuri , Okubo Yu , Masai Kyohei , Asakura Keisuke , Emoto Katsura , Asamura Hisao 
Published: October 2023

Abstract
Purpose
Salvage surgery for non-small cell lung cancer (NSCLC) is expected to become increasingly more common; however, the association between pathologic features and the postoperative prognosis remains unclear. This study aimed to clarify the survival impact of pathologic characteristics after salvage lung resection.
Methods
Twenty-three patients who underwent salvage surgery following definitive chemoradiotherapy or systemic therapy for initially unresectable NSCLC from 2010 to 2020 were enrolled in this study. The tumor slides were reviewed to determine the size of the tumor bed and the proportions of viable tumor, necrosis, and stroma according to the recent recommendations from the International Association for the Study of Lung Cancer (IASLC).
Results
Initially, 18 patients (79%) had clinical stage IIIB-IV disease. Six (26%) received chemoradiotherapy and 17 (74%) received systemic therapy alone. A major pathologic response (MPR, ≤10% of viable tumor) was observed in 6 patients, and 4 patients achieved a pathological complete response. The 3-year overall and recurrence-free survival rates (OS and RFS) were 78.6% and 59.2%, respectively. There was no significant difference in OS between patients with and without MPR, and even non-MPR patients achieved a favorable 3-year OS of 70.2%. Meanwhile, patients with high (≥30%) stroma showed significantly better OS than those with low (<30%) stroma (3-year OS: 100% vs. 23.3%, p < 0.001).
Conclusion
The proportion of stroma based on the recent IASLC recommendations was an important feature for predicting long-term survival after salvage lung resection. A low-stroma signature may serve as an indicator for considering proactive postoperative therapies after salvage surgery.
Trial registration number and date of registration
This study was approved by the institutional ethics committee of Keio University School of Medicine on September 16th, 2020 (registration no. 20200092).
Medium-chain inulin alleviates the obesity and improves systemic health in diet-induced obese mice via mediating the gut microbiome and metabolome
Authors: Wang Yunpeng , Kim Eunyoung , Cui Jiamei , Zhang Chongyu , Guo Cuihua , Lee Yunkyoung , Zhang Guiguo 
Published: October 2023

Abstract
Background Inulin is well known as a natural dietary fiber with multiple beneficial effects on promoting the physiological and intestinal health of hosts. However, it is unclear whether medium-chain inulin can inhibit high-fat diet (HFD)-induced obesity in mice and its mechanism(s) that underlie such effects. In this study, we tested the hypothesis that medium-chain inulin consumption can counteract the obesity in HFD-fed mice by selectively modulating the gut microbiota, metabolome, and metabolic pathways.
Results The results shown that the medium-chain inulin is a polymer primarily consisting of fructose linked 2,1 glycosidic bonds with an average degree polymerization of 12. Among them, molecules of different chain lengths form spherical or cross-linked network spatial structures by folding and coiling. Medium-chain inulin supplementation (3% or 5%) reduced lipid deposition in tissues, ameliorated intestinal health, and thus prevented diet-induced obesity in mice. Furthermore, dietary inclusion of inulin shaped a significantly different microbial community by specially increasing the abundances of Bacteroidota, Faecalibaculum, Bifidobacterium, Parasutterella, Lactobacillaceae, Bacteroides, Clostridium_sensu_stricto_1, and Akkermansia in inulin-supplemented groups compared with the HFD group. Additionally, dietary inulin supplementation enhanced the concentrations of nicotinamide, indole-3-acetate, 5-hydroxytryptophan, maltose, taurocholic acid, aldosterone 5α-dihydrotestosterone, and corticosterone in gut content of HFD-fed mice, and thus modulated certain energy utilization-related metabolic pathways. Especially, those significantly modulated microbes and metabolites by inulin supplementation positively correlated with ameliorated healthy parameters. Therefore, medium-chain inulin inhibits HFD-induced obesity by specifically modulating key gut microbes and metabolites, thereby affecting the inulin-gut microbiota/metabolome-tissue (phenotype) axis.
Conclusions Taken together, dietary inulin supplementation improved the gut barrier and physiological health, while alleviated HFD-induced obesity and complications of mice, including fat deposition and metabolic disorders, etc. This beneficial effect was attributed to the fact that feeding medium-chain inulin could specifically promote certain key beneficial gut bacteria and metabolites, and thus arouse energy utilization-related metabolic pathways alteration. Thus, medium-chain inulin can be employed as a potential functional food or therapeutic agent to prevent or treat diet-induced obesity in the host.
Morphological and molecular diversity of underutilized and cultivated Allium species from India
Authors: Benke Ashwini Prashant , Vijay Mahajan , Digambar Mokat N. 
Published: October 2023

Abstract
The Allium is the most diverse genus of family Alliaceae among horticultural crops. It holds unknown potential for commercial traits such as vegetables, medicines, spices and ornamental uses. The genus deals with controversy among species and subspecies sectioning due to huge agro-morphological diversity. The current study demonstrated the effectiveness of morphological descriptors for capturing intra- and inter-species variability in the Allium genus. Here, 13 qualitative and 8 quantitative features on the inflorescence, leaf, scape, and seed of 27 Allium accessions from 14 Allium species were assessed. These characteristics clearly distinguish the species and subspecies. The thirteen qualitative characteristics elucidate the species' taxonomic relationships. Additionally, the UPGMA dendrogram created using these attributes supported the basal location of species and the differences between them. The two major groups formed on basis of leaf type and further sub-classified with other traits. Further random set of 50 ILP markers evaluated for polymorphism among 27 Allium accessions including A. cepa and A. sativum. The species had a high level of transferability and locus conservation (20.6–96.50%). A. sativum recorded the highest cross-specific amplification (> 82%), followed by A. przewalskianum and A. macranthum, whereas A. hookeri had the lowest amplification. ILP markers have an average PIC value of 0.21, with a range of 0.06 to 0.40. More polymorphism and variety among Allium species were found in this study than in other studies. In order to promote horticultural traits through breeding activities, the descriptor created through qualitative trait can be successfully employed for Allium interspecific diversity investigations.
A Systematic Review on The Applications of Machine Learning for Fetal Birth Weight Prediction
Authors: Mane Deepak T. , Mante Jyoti , Bakare Anuradha Amar , Gandhi Yatin , Khetani Vinit , Mahajan Rupali Atul 
Published: October 2023

Abstract

In order to protect the maternal and infant safety, birth weight is an important indicator during fetal development. A doctor's experience in clinical practice, however, helps estimate birth weight by using empirical formulas based on the experience of the doctors. Recently, birth weights have been predicted using machine learning (ML) technologies. A machine learning model is built on the basis of a collection of attributes learns to predict predefined characteristics or results. Using a machine learning model, input and output are modeled together and then a set of models are trained on the data. It is possible to use machine learning for a variety of tasks such as predicting risks, diagnosing diseases, and classifying objects due to its scalability and flexibility, which are advantages over conventional methods. This research reviews the machine learning classification models used previously by various researchers to predict fetal weight. In this paper 85 studies were reviewed. Machine learning approach was considered as a better option to predict the fetal weight in all the studies included in this paper. The findings of this research show that the accuracy rate of using machine learning applications for fetal birth weight prediction is above 60% in all the studies reviewed.
In vitro and in vivo evaluation of Noscapine as a potential antimalarial vis-à-vis standard Dihydroartemisinin (DHA) against Plasmodium falciparum 3D7, P. falciparum clinical isolate Pf140/SS and P. berghei ANKA
Authors: Babu Swaraj Kumar , Maharana Sameer , Chhatria Satyaranjan , Sahoo Dibya Ranjan , Nanda Ashirbad , kanhar Satish , Behera Prativa K. , Mohanty Sanjib , Naik Pradeep Kumar , Sahu Praveen Kishore 
Published: October 2023

Abstract
Malaria is a global public health menace. The quest for new antimalarials and adjuvants for malaria in the backdrop of artemisinin resistance has been enormous. This study evaluates the comprehensive antimalarial activity of the natural phytochemical compound Noscapine, against Plasmodium falciparum 3D7 strain (Pf3D7), clinical isolate (Pf140/SS) and in Plasmodium berghei ANKA (PbA), inhibiting in vitro and in vivo parasite growth under controlled conditions as evaluated through the ring-stage survival assay, phenotypic assessments and SYBR-green based fluorescence assay. Cytotoxicity of Noscapine was evaluated against the J774. A.1 murine macrophage cell line besides profiling its hemolysis activities against human RBCs. The antimalarial efficacy of Noscapine against Pf3D7 and Pf140/SS was similar or better than standard antimalarial Dihydroartemisinin (DHA), with the IC50 value of 7.68±0.88 and 5.57±0.74 nM/mL respectively along with more than 95% inhibition in infected Wister albino rats with PbA after 4-day suppressive test. Importantly, unlike DHA, no toxicity symptoms were observed with CC50 value 1748 nM/mL or hemolysis with Nospcapine, even at extremely high concentrations. Based on the published literature as on date, this is the first report on native Noscapine, which has shown potent antimalarial efficacy and safety profiles vis-à-vis standard antimalarial DHA, demonstrated through in vitro and in vivo models of animal and clinical malaria parasites.