bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the T1565C gene polymorphism encoding integrin beta 3 in the development of thrombotic events and its influence on the efficiency of anti-platelet therapy
Authors: Изможерова Н.В. , Попов А.А. , Антропова И.П. , Кадников Л.И. , Испавский В.Е. , Шамбатов М.А. , Браженко Г.Г. , Салов Д.В. 
Published: November 2023

В обзоре анализируются современные представления о структурно-функциональных особенностях интегринов у человека; исследования связи между полиморфизмом гена T1565C, кодирующего интегрин бета‑3 (ITGβ3), тромботических явлений и эффективностью применяемых антитромбоцитарных препаратов; рассмотрена целесообразность исследования на наличие данного полиморфизма. Анализ проведен на основе публикаций, представленных в базах данных и web-ресурсах: MEDLINE, PubMed, Google Scholar, Cyberleninka, электронной библиотеке eLibrary, охватывающих временной период с 1989 по 2022 г. Критериями включения в обзор являлись статьи на русском и английском языках, результаты когортных и рандомизированных исследований, мета-анализов, систематические обзоры исследуемой проблемы, а также описания клинических случаев. Критериями исключения из выборки послужили исследования с отсутствием четко сформулированных выводов или наличием противоречивых результатов.
This review describes the main modern provisions on the structural and functional features of integrins in humans; studies of the relationship between polymorphism of the T1565C gene encoding integrin beta 3 (ITGβ3), thrombotic events and the effectiveness of antiplatelet drugs used; the expediency of research for the presence of this polymorhism is considered. Data analysis was carried out on the basis of publications presented in databases and web resources: MEDLINE, PubMed, Google Scholar, Cyberleninka, eLibrary, covering the time period from 1989 to 2022. The inclusion criteria for the review were articles in Russian and English, results of cohort and randomized studies, meta-analyses, systematic reviews of the problem under study, as well as descriptions of clinical cases. Exclusion criteria were studies with no clear-cut conclusions or conflicting results.
MUSCL-scheme of the third order of accuracy on a non-uniform structured grid
Authors: Кочарина А.Р. , Чирков Д.В. 
Published: November 2023

Противопотоковая схема конечных объемов с MUSCL-реконструкцией на грань ячейки третьего порядка распространена на случай неравномерной структурированной сетки. На примере одномерного нелинейного уравнения переноса исследован порядок аппроксимации для исходной реконструкции с постоянными коэффициентами и модифицированной MUSCL-схемы с коэффициентами, зависящими от шагов сетки. Показано, что порядок аппроксимации зависит от вида неравномерной сетки. Рассмотрены случаи сетки с постоянным законом сгущения и произвольной неравномерной сетки. Аналитически и численно показано, что неравномерная MUSCL-схема с коэффициентами, зависящими от шагов сетки, имеет третий порядок аппроксимации на неравномерной сетке с постоянным законом сгущения и второй порядок на произвольной сетке. Также показано, что MUSCL-схема с постоянными коэффициентами вообще не аппроксимирует исходное уравнение на произвольной неравномерной сетке. Неравномерная MUSCL-реконструкция внедрена в численный алгоритм расчета течений несжимаемой жидкости.На двумерной задаче обтекания кругового цилиндра и трехмерной задаче о течении жидкости в проточном тракте гидротурбины показана более высокая точность предложенной схемы.
An upwind finite volume scheme with third-order MUSCL-reconstruction at the cell interface is extended to non-uniform structured grids. The order of approximation of the original MUSCL-scheme with reconstruction using constant coefficients and the modified MUSCL-scheme with coefficients dependent on the grid steps is investigated for 1D nonlinear transport equation. It is shown that the order of approximation depends on the type of non-uniform grid. The cases of a grid with a constant clustering law and an arbitrary non-uniform grid are considered. It is shown analytically and numerically, that the non-uniform MUSCL-scheme with coefficients depending on the grid spacing has the third order of approximation on a non-uniform grid with a constant clustering law and the second order on an arbitrary grid. It is also shown that the MUSCL-scheme with constant coefficients does not approximate the original equation at all on an arbitrary non-uniform grid. Non-uniform MUSCL-reconstruction is introduced into the numerical algorithm for calculating incompressible fluid flows. Higher accuracy of the proposed scheme is demonstrated for a 2D problem of the flow around a circular cylinder and for a 3D fluid flow in a hydraulic turbine.
On Application of Canonical Decomposition for the Visualization of Results of Multiparameter Computations
Authors: Alekseev A.K. , Bondarev A.E. , Pyatakova Yu.S. 
Published: November 2023

The approximation of the tensor appearing at a discretization of the multidimensional function is considered from the viewpoint of storing and treating of the results of parametric computations obtained in computational aerogasdynamics. The new algorithm for the computation of the canonical decomposition using gradient descent and approximately decomposable goal functional is described.
This algorithm applies the random set of points on the hyperplane orthogonal to the computed core of the canonical decomposition (“umbrella”) that ensures its flexible application for an approximation of the tensors with a priori unknown rank and may be naturally transferred on such tensor decomposition as the tensor train. The results of the numerical tests are presented for the model six-dimensional functions and for an ensemble of the numerical solutions for the two-dimensional Euler equations. These equations describe the flow of the compressible gas with two crossing shock waves. The Mach number and angles of the flow deflection serve as the flow parameters. The results are provided for the dimensionality 3 (simple numerical solution) and 4 (the ensemble of the numerical solutions in dependence on the Mach number).
Hydrogeological Investigations of Groundwater and Surface Water Interactions in the Berg River Catchment, Western Cape, South Africa
Authors: Mabokela Seiphi Prudence , Malaza Ntokozo 
Published: November 2023

The Berg River Catchment based in the Western Cape Province, South Africa services the greater Cape Town area with water, subsequent to supplying the vast agricultural activities that exist in the middle and the lower reaches. This study thus investigates the hydrogeochemical interactions between surface and groundwater in the Berg River Catchment with the aim of establishing trends and transfer of constituents between the surface and groundwater systems, investigates the role that geology plays in water chemistry as well as identifies the geochemical processes controlling surface and groundwater chemistry in the catchment. This study was carried out using three types of research designs namely i) experimental research design; ii) field research design and meta-analysis research design. Furthermore, the study made use of hydrochemical data ranging from 2003 to 2013 obtained from the National Water Monitoring Database owned and maintained by the Department of Water and Sanitation and data that were sampled in 2016 by authors and analyzed using the ICP-MS Technique Ground Water Chart, Arc-GIS and Geosoft (Oasis Montaj) were further employed to model the data. The results indicated that: i) in the Upper Berg there is not much interaction and transfer of constituents between surface and groundwater; ii) the Middle Berg, however, indicated a degree of interaction with the sharing of constituents between the two water systems and iii) the Lower Berg indicated only NaCl water type also noting that the area situated near the river mouth whereby there is the mixing of river and seawater.
Comparison of Machine Learning Methods for Satellite Image Classification: A Case Study of Casablanca Using Landsat Imagery and Google Earth Engine
Authors: Ouchra Hafsa , Belangour Abdessamad , Erraissi Allae 
Published: November 2023

Satellite image classification is crucial in various applications such as urban planning, environmental monitoring, and land use analysis. In this study, the authors present a comparative analysis of different supervised and unsupervised learning methods for satellite image classification, focusing on a case study in Casablanca using Landsat 8 imagery. This research aims to identify the most effective machine-learning approach for accurately classifying land cover in an urban environment. The methodology used consists of the pre-processing of Landsat imagery data from Casablanca city, the authors extract relevant features and partition them into training and test sets, and then use random forest (RF), SVM (support vector machine), classification, and regression tree (CART), gradient tree boost (GTB), decision tree (DT), and minimum distance (MD) algorithms. Through a series of experiments, the authors evaluate the performance of each machine learning method in terms of accuracy, and Kappa coefficient. This work shows that random forest is the best-performing algorithm, with an accuracy of 95.42% and 0.94 Kappa coefficient. The authors discuss the factors of their performance, including data characteristics, accurate selection, and model influencing.
Pengembangan Olahan Produk Value Added Dengan Memanfaatkan Kolam Akuaponik Sebagai Peluang Usaha Masyarakat Pada Masa Pendemi Covid Kabupaten Kubu Raya
Authors: Fitriyani Evi Evi , Nuraenah Nani , Laksono Untung Trimo , Putra Yudha Perdana , Masi Aloysius , Novalina Kristina , Deviarni Ika Meidy 
Published: November 2023

Pendemi Covid-19 sangat berdampak pada sektor ekonomi masyarakat di Kabupaten Kubu Raya. Hal ini dilihat dari daya beli masyarakat sangat menurun akibat pandemi Covid-19 sehingga berpengaruh terhadap keberlangsungan kehidupan sehari-hari. Oleh karena itu pembinaan dan bantuan untuk masyarakat pada masa pandemi perlu menjadi perhatian. Peluang usaha baru yang menjanjikan salah satunya Produk value added dengan memanfaatkan lahan kolam yang ada diperkarangan rumah dengan membudidayakan ikan secara akuaponik, dimana kelebihan akuaponik ini bisa menjadi percontohan bagi masyarakat yang lain. Dengan diaplikasikannya system akuaponik ini nantinya usaha yang dikembangkan tidak hanya menghasilkan satu produk tapi 3 produk komoditas sekaligus, antara lain usaha budidaya ikan nila, usaha budidaya sayur dan usaha pengolahan produk value added. Tujuan dari kegiatan PKM ini adalah 1) Pemanfaatan lahan kolam pada perkarangan rumah sebagai kolam akuaponik dan hasil dari budidaya ikan dan sayuran dapat dijadikan produk olahan yang bernilai tambah, 2) Meningkatnya usaha masyarakat melalui pendampingan dan pelatihan teknis serta keterampilan yang dapat menunjang kesejahteraan masyarakat bidang pengolahan produk perikanan. Adapun rencana kegiatan yang dilakukan dilapangan dalam pelaksanaan program PKM ini meliputi 1) Tim pengusul melakukan survey ke lapangan, 2) Pendampingan atau pelatihan budidaya ikan dengan system akuaponik, 3) Pelatihan atau praktek Pengolahan Produk Berbasis Ikan nila, dan 4) Monitoring tingkat keberhasilan pelaksanaan PKM. Pelatihan dan penyuluhan mengenai kolam akuaponik bagi masyarakat RT 011/RW 006 Desa Sungai Raya Dalam memberikan dampak yang positif karena dengan penerapan akuaponik ini memberikan hasil yang baik bagi pengguna dan diharapkan juga adanya keberlanjutan dari program PKM ini untuk kedepan sehingga akuaponik ini bisa menjadi program agrowisata bagi bagi pemerintah dan masyarakat yang lain.
ANALISIS PENGARUH JENIS BAHAN BAKAR TERHADAP NILAI EMISI GAS BUANG PADA DIESEL ENGINE COMMON RAIL SYSTEM
Authors: Saksono Puji 
Published: November 2023

AbstrakEmisi gas buang kendaraan bermotor mempunyai berbagai senyawa kimia, dimana nilainya salah satunya tergantung dari jenis bahan bakar yang digunakan. Penelitian dilakukan untuk mengetahui pengaruh penggunaan jenis bahan bakar dengan variasi putaran engine terhadap nilai emisi gas buang pada mobil Diesel engine dengan sistem common rail. Adapun tahap awal penelitian dilakukan survey menggunakan kuisioner googleform dan dilanjutkan pengujian engine menggunakan jenis bahan bakar Solar, Dexlite, dan PertaminaDex dengan variasi putaran engine sebesar 900, 1500, 2500, 3500 dan 4000 rpm. Engine yang digunakan adalah mobil merk Toyota Type Hilux 2.4 G Double Cabin tahun 2018. Hasil pengujian didapatkan nilai emisi gas buang paling rendah yaitu dengan menggunakan jenis bahan bakar PertaminaDex dengan putaran engine 900 rpm (idle) untuk gas CO dan HC, serta pada putaran engine 4000 rpm untuk gas NOx. Sedangkan nilai emisi paling tinggi yaitu dengan menggunakan jenis bahan bakar Solar pada saat putaran engine 4000 rpm untuk gas CO dan HC serta pada putaran engine 900 rpm (idle) untuk gas NOx nya. Kata kunci: Engine tipe common rail, pengujian, nilai emisi gas buang
PEMANFAATAN LIMBAH PLASTIK SEBAGAI PENGUAT PADA MATERIAL KOMPOSIT BERMATRIKS EPOXY
Authors: Waluyo Marhadi Budi 
Published: November 2023

Sampah botol plastik merupakan sampah yang paling banyak dikonsumsi oleh masyarakat baik individu, toko, maupun perusahaan besar. Pencemaran lingkungan yang disebabkan oleh sampah plastik sangat tinggi. Salah satu pemanfaatan sampah plastik sebagai komposit. Dalam penelitian ini komposit tersusun dari epoxy sebagai matriks dan sampah botol plastik jenis PET sebagai pengisi. Penelitian ini bertujuan untuk mengetahui variasi komposisi pengisi terhadap kekuatan impak dan kekerasan material komposit. Proses pembuatan spesimen komposit mengunakan variasi cacahan botol plastik dengan persen berat. Komposisi pengisi yang digunakan dimulai dari 2.5%, 5%, 7.5%, 10%. Penambahan filler diiringi pengurangan matriks yang digunakan dari 100% epoxy. Komposit dibuat dengan proses hand lay-up. Dari hasil penelitian diperoleh bahwa semakin besar variasi filler yang digunakan maka nilai kekuatan impact dan kekerasan meningkat. Kekuatan impact tertinggi berada pada variasi 10% wt sebesar 16.91 Joule. Hal ini disebabkan karena variasi 10% wt lebih mampu menahan benturan kejut dari pada variasi 2.5%wt. Hasil data tertinggi uji kekerasan pada penelitian ini berada pada variasi 1 (100%/0) sebesar 80,5 shore D dan variasi 5 (90%/10%) yang nilai kekerasannya tidak berbeda jauh dari variasi 1 sebesar 80 shore D.Kata Kunci: Epoxy, Komposit, Sampah Botol Plastik, Uji Impact, Uji Kekerasan
TARIMSAL SULAMADA RÜZGAR VE GÜNEŞ ENERJİ SİSTEMLERİNİN KULLANIM OLANAKLARININ ARAŞTIRILMASI: ESKİŞEHİR ÖRNEĞİ
Authors: POLAT Mahmut , ARABACI Tolga , CENGİZ Adnan 
Published: November 2023

Sera etkisi nedeniyle, iklim değişiklikleri gün geçtikte olumsuz etkilerini artan bir şekilde dünyamızda hissettirmeye başlamıştır. Dolayısıyla, fosil kaynaklı yakıt kullanımını azaltmak için güneş ve rüzgâr gibi temiz enerji ve kısıtlı olan su kaynaklarını tasarruflu kullanmak artık hayati bir değer taşımayı geçmiş durumdadır.
Bu çalışmanın amacı, Eskişehir iklim şartlarında özellikle tarımsal sulamanın yapıldığı zaman periyodunda; güneş ve rüzgâr enerji sitemlerinin enerji üretim performanslarının ve sulama enerji etkinliklerinin araştırılmasıdır. Projede sistemlerden elde edilen enerji kullanılarak sulama kuyularından çıkarılan su, 350 ton kapasiteli havuzda depolanmakta ve sulamanın gerektiği zamanlarda kullanılmaktadır. Projenin sonuçlarına göre; sistemlerin 1 kWe kurulu gücün üretmiş olduğu enerji; rüzgârda 974 kWh/kWe, Güneşte ise 1.357,74 kWh/kWe olarak gerçekleşmiştir. Sistemlerin geri kazanım (kendini amorti) süresi, rüzgâr enerjisi sisteminde 12,5 yıl, PV güneş enerjisi sisteminde ise 7,1 yıl olarak hesaplanmıştır. Maliyet analizi açısından; sulama suyunun temininde alternatif enerji kaynakları olarak rüzgâr enerjisi, PV güneş enerjisine nazaran 1,87 kat daha pahalı olarak elde edilmiştir. Sonuç olarak; gerek birim enerji maliyeti ve gerekse kurulum ve bakım kolaylığı yönünden PV güneş enerjisi sistemi daha avantajlı olarak öne çıkmıştır.
Association of Tooth Loss with Alzheimer’s Disease Tau Pathologies Assessed by Positron Emission Tomography
Authors: Matsumoto Hideki , Tagai Kenji , Endo Hironobu , Matsuoka Kiwamu , Takado Yuhei , Kokubo Naomi , Shimada Hitoshi , Goto Tetsuya , Goto Tazuko K. , Higuchi Makoto 
Published: November 2023

Background: Deterioration of the oral environment is one of the risk factors for dementia. A previous study of an Alzheimer’s disease (AD) model mouse suggests that tooth loss induces denervation of the mesencephalic trigeminal nucleus and neuroinflammation, possibly leading to accelerated tau dissemination from the nearby locus coeruleus (LC). Objective: To elucidate the relevance of oral conditions and amyloid-β (Aβ) and tau pathologies in human participants. Methods: We examined the number of remaining teeth and the biofilm–gingival interface index in 24 AD-spectrum patients and 19 age-matched healthy controls (HCs). They also underwent positron emission tomography (PET) imaging of Aβ and tau with specific radiotracers, 11C-PiB and 18F-PM-PBB3, respectively. All AD-spectrum patients were Aβ-positive, and all HCs were Aβ-negative. We analyzed the correlation between the oral parameters and radiotracer retention. Results: No differences were found in oral conditions between the AD and HC groups. 11C-PiB retentions did not correlate with the oral indices in either group. In AD-spectrum patients, brain-wide, voxel-based image analysis highlighted several regions, including the LC and associated brainstem substructures, as areas where 18F-PM-PBB3 retentions negatively correlated with the remaining teeth and revealed the correlation of tau deposits in the LC ( r = –0.479, p = 0.018) primarily with the hippocampal and neighboring areas. The tau deposition in none of the brain regions was associated with the periodontal status. Conclusions: Our findings with previous preclinical evidence imply that tooth loss may enhance AD tau pathogenesis, promoting tau spreading from LC to the hippocampal formation.
Effect of Virgin Coconut Oil Supplementation on Cognition of Individuals with Mild-to-Moderate Alzheimer’s Disease in Sri Lanka (VCO-AD Study): A Randomized Placebo-Controlled Trial
Authors: Fernando Malika G. , Silva Renuka , Fernando W.M.A.D. Binosha , de Silva H. Asita , Wickremasinghe A. Rajitha , Dissanayake Asoka S. , Sohrabi Hamid R. , Martins Ralph N. , Williams Shehan S. 
Published: November 2023

Background: Virgin coconut oil (VCO) is a potential therapeutic approach to improve cognition in Alzheimer’s disease (AD) due to its properties as a ketogenic agent and antioxidative characteristics. Objective: This study aimed to investigate the effect of VCO on cognition in people with AD and to determine the impact of apolipoprotein E ( APOE) ɛ4 genotype on cognitive outcomes. Methods: Participants of this double-blind placebo-controlled trial (SLCTR/2015/018, 15.09.2015) were 120 Sri Lankan individuals with mild-to-moderate AD (MMSE = 15-25), aged > 65 years, and they were randomly allocated to treatment or control groups. The treatment group was given 30 mL/day of VCO orally and the control group, received similar amount of canola oil, for 24 weeks. The Mini-Mental Sate Examination (MMSE) and Clock drawing test were performed to assess cognition at baseline and at the end of the intervention. Blood samples were collected and analyzed for lipid profile and glycated hemoglobin (HbA1 C) levels.∥ Results: There were no significant difference in cognitive scores, lipid profile, and HbA1 C levels between VCO and control groups post-intervention. The MMSE scores, however, improved among APOE ɛ4 carriers who had VCO, compared to non-carriers (2.37, p = 0.021). APOE ɛ4 status did not influence the cognitive scores in the control group. The attrition rate was 30%.∥ Conclusion: Overall, VCO did not improve cognition in individuals with mild-to-moderate AD following a 24-week intervention, compared to canola oil. However, it improved the MMSE scores in APOE ɛ4 carriers. Besides, VCO did not compromise lipid profile and HbA1 C levels and is thus safe to consume.
Pendampingan Pembuatan Laporan Keuangan dan Analisa Usaha Tani Pembibitan Nanas di Kecamatan Ngancar Kabupaten Kediri
Authors: Nursandi Fatimah , Santoso Untung , Septia Erfan Dani , Fauziyah Fauziyah 
Published: November 2023

Kecamatan Ngancar kabupaten Kediri dengan luas wilayah 94,05 km2 terdiri dari 10 desa dengan jumlah penduduk 2.012 jiwa. Mayoritas pekerjaan masyarakat Ngancar sebagai petani nanas. Petani nanas dibentuk menjadi 8 kelompok tani. Kecamatan Ngancar Kediri merupakan penghasil nanas yang terbesar di Jawa Timur, dimana 75 % wilayahnya ditanami buah nanas. Produksi nanas di Jawa Timur tahun 2021 sebesar 705,88 ton atau 6,9 % dari produksi Nasional dan menduduki urutan ke 6 (enam). Terdapat berbagai macam jenis nanas di wilayah Ngancar diantaranya nanas PK 1 (Pasir Kelud 1), Nanas Simplek, Nanas Queen. Produk nanas dari Ngancar Kediri sudah menembus pasar global (ekspor). Permasalahan dari petani adalah aspek keuangan. Terbatasnya kemampuan dalam pemahaman sistem keuangan. Petani belum bisa mencatat transaksi keuangan dan membuat laporan keuangan. Kegiatan PKM melakukan pendampingan, pelatihan sistem keuangan, membuat laporan keuangan serta melakukan analisa hasil usaha tani. Dengan PKM ini, petani nanas 80% sudah bisa dan mampu mencatat transaksi keuangan, menghitung biaya produksi, membuat laporan keuangan serta melakukan analisa usaha tani. Kegiatan ini diharapkan bisa mencetak petani nanas sebagai wirausaha bibit nanas sesara mandiri serta dapat meningkatkan pendapaatan petani nanas.
Fine as a type of disciplinary penalty against prisoners of war
Authors: Orel Yu. V. 
Published: November 2023

The article examines national legislation and international legal acts operating in the field of international humanitarian law, in particular, regarding the treatment of prisoners of war. It has been emphasized that in the modern legal science of Ukraine there are no relevant scientific works devoted to the study of issues of bringing prisoners of war to disciplinary responsibility.
Emphasis is placed on the fact that the Geneva Convention on the Treatment of Prisoners of War of 1949, in the conditions of martial law in our country, played an important role, determined the need and became the basis for the creation of appropriate national legislation regulating social relations in this area.
It has been established that the legal position of prisoners of war is not the same and depends on their military rank, in particular, this is clearly expressed, for example, when they are recruited to work, brought to disciplinary responsibility, etc.
It has been found that the fine, as a disciplinary sanction that can be applied to prisoners of war, from the point of view of its content and method of presentation, is characterized by its incomprehensibility, uncertainty and lack of terms used in its description in the national legislation. It has been concluded that the domestic legislator almost completely adopted (copied) this regulatory provision from the international legal act, without taking into account the realities and specifics of domestic legislation. In this regard, concerns have been expressed about its possible practical application in the form in which it currently exists.
It has been established that the fine for prisoners of war, in contrast to convicts, is assigned according to the system of penalty days, and consists in assigning to the prisoner of war the daily amount of the fine, determined in accordance with the legislation in the national currency of Ukraine. A clearly defined number of days (term), during which he or she is obliged to pay the corresponding amount of money has been set.
Emphasis is placed on the imperfection of national legislation, in particular, in the part of defining and applying fines to prisoners of war, on the basis of which the author has proposed appropriate changes and additions to it.