bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Tibetan Heat Sources and Heat Waves in China
Authors: Tan Ziyuan , Liu Yuzhi , Shao Tianbin , Luo Run , Luo Min , Xie Yongkun 
Published: October 2023

Abstract
The Tibetan Plateau (TP), known as the “Third Pole,” profoundly affects weather and climate at regional and global scales. In this study, we investigate the characteristics of heat waves in China and their association with the TP heat source. The results show that during the summertime from 1980 to 2020, the frequency of heat wave days that hit eastern China and northwest China increased at rates of 0.09 and 0.24 days yr−1, respectively, accompanied by an increase in the atmospheric heat source (AHS) over the TP by over 2 W m−2 yr−1 under the background of global warming. The enhanced TP heat source induces an anomalous upper-tropospheric anticyclone, which caused the western Pacific subtropical high and South Asia high to be stronger and closer to each other, causing descending motions over eastern China and consequently more heat waves. At the same time, the enhanced TP heat source weakened the westerlies, thereby favoring the occurrence and maintenance of the anticyclone centered in northwest China and creating more heat waves due to strong descending motions. Therefore, the association between the TP heat source and heat waves in China provides relevant information for studying the mechanism and future changes of heat waves.

Significance Statement
The Tibetan Plateau significantly affects the surrounding weather and climate. We find that there are some linkages between the Tibetan heat source and heat waves in China. The stronger the Tibetan heat source is, the more heat waves hit China. The enhancement of the Tibetan heat source could induce an anomalous upper-tropospheric anticyclone by affecting the western Pacific subtropical high and South Asia high, consequently causing descending motions over eastern China and the resulting heat waves. The weaker westerly due to the enhanced Tibetan heat source favors the occurrence of the anticyclone centered in northwest China, leading to more heat waves by descending motions. This study reveals a potential contributor to heat waves in China, providing some clues for better prediction in the future.
Tribological and corrosion characteristics of tetra hybrid particulate-reinforced aluminum composites for aerospace and automotive applications
Authors: Ashebir Demeke Abay , Mengesha Getinet Asrat , Sinha Devendra Kumar , Bereda Yodit Birhanu 
Published: October 2023

This study investigates Hybrid Particulate-Reinforced Aluminum Matrix Composites (HPRAMCs), a material class known for exceptional physico-mechanical, tribological, and corrosion resistant properties. The research synthesizes HPRAMCs using SiC, Al2O3, graphite (Gr), and sugar cane bagasse ash (SCBA) reinforcements through a powder metallurgy process, followed by sintering at 550°C for 3 h. Comprehensive tests include X-ray diffraction (XRD) for phase analysis, physico-mechanical assessments, tribological evaluations, and corrosion resistance analyses. Notably, secondary reinforcements significantly reduce porosity, with AS4 HPRAMC exhibiting a 0.53% porosity, while AS1 HPRAMC has 1.446%. AS4 HPRAMC displays a remarkable 209.76% increase in compressive strength and a 446.40% boost in material hardness compared to pure aluminum. Secondary reinforcements also improve tribological performance, reducing wear loss by 60.27% and the coefficient of friction by 89.89%. Exceptional corrosion resistance, with an inhibition efficiency of 99.691%, is observed in the AS4 HPRAMC sample, confirmed by scanning electron microscopy (SEM). These findings underline the substantial potential of HPRAMC materials, positioning them as promising candidates for aerostructural components, aircraft systems, automobiles, spacecraft, and high-performance engineering applications.
We can connect: Imagining the future of digital practice with and by care-experienced children and young people
Authors: Larkins Cath , Crook Deborah , O’Riordan Zoe , Casey Helen , Froggett Lynn , Karolina Ismail , Farrelly Nicola 
Published: October 2023

A participatory study with care-experienced children and young people identified longstanding problems in social work with children and recommended service improvements. The authors reflected on a digital resource co-created by this study and speculated on future digital adaptations that might address some of the service development needs that children and young people identified. This was inspired by Haraway’s (1985) call to imagine cyborgification in order to break from dominant thinking while being cautious of how power operates in human-machine conjunctures. The imagined digital adaptations focus on connecting to people and places, leisure, education, accommodation, journey planning through care and systems accountability. Imagining cyborgification highlighted how digital adaptations are embedded in, and not a substitute for, trusting relationships. Adaptations must be co-developed by intergenerational groups of children and professionals. Bourdieu’s (1985 , 1986 ) notions of habitus, field and capitals could guide theoretically informed feasibility testing, drawing attention to distributions of resources. Key questions relate to: When can digital adaptations challenge the dominant habits and politics of social care, strengthen deep relationships and secure social, cultural and economic capital in the hands of young experts and their adult allies, so that systems can redress inequalities and promote accountability?
Thermal performance and economic sustainability of flat plate solar collectors using MgO and ZnO nanofluids: A comparative analysis
Authors: Choudhary Suraj , Kumar Vikash , Singhal Varun 
Published: October 2023

Considering the higher outlet temperature, the present study assessed the performance of Zinc oxide (ZnO) and Magnesium oxide (MgO) nanofluid-based flat plate solar collector at a low volumetric flow rate, that is, 30 L/h. The lower solar irradiance results in a low percentage enhancement in collector efficiency; therefore, it constraints the use of the nanofluid-based collector at such conditions. The collector efficiency was nearly 67.98% and 65.22% for 1 vol% ZnO and 0.2 vol% MgO, respectively, almost 20.57% and 16.53% more than base fluid (ethylene glycol: distilled water). For 1 vol% ZnO and 0.2 vol% MgO, the heat absorption parameter intensified by 20.48% and 17.12%, respectively. The payback period at the optimum concentrations of ZnO and MgO nanofluid-based flat plate solar collector compared to electric heating was ∼2.97 and 3.69 years, respectively. In terms of present worth, the cost savings in a life span of 15 years was approximately 1918.18 and 1839.05 USD for 1 vol% ZnO and 0.2 vol% MgO, respectively. Such gains could be extended using large-sized areas of collectors. The 1 vol% ZnO at the flow rate of 30 L/h has the shortest payback period and highest cost-saving; hence, profoundly recommended in the flat plate solar collector instead of the base fluid.
Relaxation Effect of Schisandrol A on Isolated Thoracic Aorta and its Mechanism in Rats
Authors: Qiu Xudong , Dong Yang , Wang Bihan , Yang Shuo , Sun Jinghui , Li He , Chen Jianguang , Du Xingxu , Wang Chun Mei 
Published: October 2023

Background Schisandra chinensis (S. chinensis) is a drug commonly used in the clinical treatment of cardiovascular diseases in Traditional Chinese Medicine. However, the specific components and mechanisms of its action are still unclear. We screened six kinds of lignans from S. chinensis with high content and found that schisandrol A and schisantherin A had a strong vasorelaxant effect. The purpose of this study was to investigate the relaxation and underlying mechanism of schisandrol A in the isolated thoracic aorta of rats. Materials and Methods Isolated rat endothelium-intact and endothelium-removed thoracic aorta strips were pre-constricted with phenylephrine (PE), and the relaxation of schisandrol A on the strips was observed. Then, the mechanism was explored by pre-incubating the strips with nitric oxide synthetase inhibitor Nɷ-nitro-l-arginine methyl ester (L-NAME), cyclooxygenase inhibitor (indomethacin), potassium channel blockers 4-aminopyridine (4-AP), barium chloride (BaCl2), tetraethylamine (TEA), and glibenclamide, respectively, and changing the calcium concentration in the bath. In addition, expressions of endothelial nitric oxide synthetase (eNOS) mRNA and protein in rat thoracic aorta were detected. Results Schisandrol A induced both endothelium-dependent and endothelium-independent relaxation of isolated thoracic aorta strips of rats, and the mechanism might be related to promoting the synthesis of NO, inhibiting Ca2+ release from the sarcoplasmic reticulum, and blocking the Ca2+ channels. Conclusion These discoveries may provide a theoretical basis for the traditional application of S. chinensis to treat cardiovascular disease.
Health-Related Quality of Life Outcome Measures in Individuals With Hereditary Hemorrhagic Telangiectasia: A Scoping Review
Authors: Gong Anna J. , Garg Tushar , Khalil Adham , Gowda Prateek C. , Mathai Stephen C. , Rowan Nicholas R. , Merlo Christian A. , Weiss Clifford R. 
Published: October 2023

Background Studies evaluating health-related quality of life (HRQOL) in patients with hereditary hemorrhagic telangiectasia (HHT) have expanded rapidly in the past decade. These studies have evaluated QOL aspects ranging from the general QOL for patients living with HHT to intervention-specific outcomes. However, few tools have been fully validated across the spectrum of disease manifestations and interventions in HHT. Objective In this scoping review, we aim to map the literature on HHT-QOL metrics, identify gaps, inform future QOL research, and facilitate future metric development. Methods We analyzed articles in English that assessed at least 1 measure of general HRQOL, including physical health, mental health, social health, or intervention-specific QOL in patients with HHT. Searches across 2 bibliographic databases (PubMed and Scopus) yielded 186 articles after duplicates were removed. Sixty-three studies met eligibility criteria: 22 prospective studies (34.9%), 20 retrospective studies (31.7%), 12 cross-sectional studies (17.5%), 6 randomized controlled trials or secondary analyses of a randomized controlled trials (9.5%), 2 qualitative studies (3.2%), and 1 case-control study (1.6%). Two additional studies—1 prospective and 1 cross-sectional study—were identified at the October 2022 14th International HHT Conference and included, making a total of 65 studies. Results The 65 eligible studies used 30 QOL instruments. Twenty studies characterized baseline HRQOL, and 45 studies evaluated QOL before and after treatment. Of those 45 studies, 37 evaluated HRQOL before and after therapies targeting epistaxis and nasal symptoms, 4 targeted therapies for liver arteriovenous malformations and high-output heart failure, 3 evaluated therapies for both epistaxis and gastrointestinal bleeding, and 1 evaluated treatment targeting gastrointestinal bleeding alone. Conclusions Comparison of results across studies remains challenging given the heterogeneity in outcomes measures. Further development of HHT-specific patient-reported outcomes instruments that capture the global illness experience of HHT is needed.
Three-Patch Reconstruction of Hourglass Supravalvar Pulmonary Artery Stenosis Mid-Term Results
Authors: Amir Gabriel , Lowenthal Alexander , Bruckheimer Elchanan , Dagan Tamir , Schiller Ofer , Shostak Eran , Frenkel Georgy , Birk Einat 
Published: October 2023

Background Some patients with pulmonary stenosis present with a complex multilevel disease that involves the valve, the leaflets, and the sinotubular junction (STJ) forming an hourglass appearance. We herein report the mid-term results of our experience with the reconstruction of the supravalvar narrowing using three pericardial patches. Material and Methods Retrospective analysis of patient charts and echocardiography studies of patients who underwent three-patch reconstruction of the pulmonary valve (PV) from 2013 to 2022. After PV transection distal to STJ, vertical incisions into the sinuses were performed, and leaflets were trimmed and thinned. The three sinuses were augmented using three pericardial patches. Results Nineteen patients underwent repair of hourglass supravalvar pulmonary stenosis. Mean weight at surgery was 9.4 kg (median 7.2, range 4.7-35); 16 patients underwent previous catheterization with unsuccessful balloon dilatation of the PV (13 pts.). Preoperative aortic/pulmonary annulus ratio was 1.02 (median 1, range 0.89-1.25). After surgery, gradients across the PV were significantly reduced (94 ± 26 vs 29 ± 9 mm Hg, P = .02). Postoperatively, 14 patients had mild or no pulmonary insufficiency (PI) and five had mild to moderate PI. At a mean follow-up of 71 months (median 78 months, range 8-137), gradients continued to decrease (29 ± 9 vs 15 ± 5 mm Hg, P < .001). Conclusion The three-patch technique for the repair of supravalvar pulmonary stenosis is simple, reproducible, and achieves excellent and long-standing relief of the right ventricular outflow tract gradient.
Overall survival following stereotactic radiosurgery for ten or more brain metastases: a systematic review and meta-analysis
Authors: Rozati Hamoun , Chen Jiarong , Williams Matt 
Published: October 2023

Abstract
Background
Brain metastases are the most common intracranial tumours. Variation exists in the use of stereotactic radiosurgery for patients with 10 or more brain metastases. Concerns include an increasing number of brain metastases being associated with poor survival, the lack of prospective, randomised data and an increased risk of toxicity.

Methods
We performed a systematic review and meta-analysis to assess overall survival of patients with ten or more brain metastases treated with stereotactic radiosurgery as primary therapy. The search strings were applied to MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL). Log hazard ratios and standard errors were estimated from each included study. A random-effects meta-analysis using the DerSimonian and Laird method was applied using the derived log hazard ratios and standard errors on studies which included a control group.

Results
15 studies were included for systematic review. 12 studies were used for pooled analysis for overall survival at set time points, with a predicted 12 month survival of 20–40%. The random-effects meta-analysis in five studies of overall survival comparing ten or greater metastases against control showed statistically worse overall survival in the 10 + metastases group (1.10, 95% confidence interval 1.03–1.18, p-value = < 0.01, I2 = 6%). A funnel plot showed no evidence of bias. There was insufficient information for a meta-analysis of toxicity.

Discussion
Overall survival outcomes of patients with ten or more brain metastases treated with SRS is acceptable and should not be a deterrent for its use. There is a lack of prospective data and insufficient real-world data to draw conclusions on toxicity.

PROSPERO ID
CRD42021246115
A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis
Authors: Arita Takuya , Namba Kenichi , Iwata Daiju , Suzuki Kayo , Ogino Yo , Mizuuchi Kazuomi , Hiraoka Miki , Kitaichi Nobuyoshi , Ishida Susumu 
Published: October 2023

Abstract
Background
Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uveits characterized by complications of idiopathic acute tubulointerstitial nephritis, and most cases present only anterior uveitis. We report a case of TINU syndrome in which the presence of choroiditis was revealed by multimodal imaging.

Case presentation
A 12-year-old male visited our hospital with a 6-day history of ocular pain and hyperemia. Conjunctival and ciliary injections, 1 + flare and 3 + cells of anterior chamber inflammation with mutton fat keratic precipitates were observed in both eyes (OU), together with redness and swelling of the optic disc OU. Laboratory tests showed slightly high levels of soluble IL-2R and serum β2 microglobulin and markedly high levels of urinary β2 microglobulin. The diagnosis of probable TINU syndrome was established on the basis of bilateral uveitis and urinalysis results in accordance with a clinical criteria of tubulointerstitial nephritis. With treatment with oral prednisolone (PSL) at 20 mg/day, ocular findings improved, and the dose of PSL was gradually reduced and withdrawn 6 months later. However, 1 month later from the withdrawal, ocular inflammation recurred with the presence of retinal exudates and snowball vitreous opacities in the peripheral retina OU. Fluorescein angiography showed leakages from peripheral retinal vessels and staining corresponding to retinal exudates. Indocyanine green angiography showed hypofluorescent dots scattered over the ocular fundus. Optical coherence tomography revealed the presence of choroidal thickening. Laser speckle flowgraphy color map showed a relatively cooler color. Findings from these multimodal images indicated the presence of subclinical choroiditis; therefore, oral PSL was administered again, and ocular inflammatory findings were improved.

Conclusions
TINU syndrome can exhibit subclinical choroiditis detected with multimodal imaging. Further studies are necessary to determine the frequency of subclinical choroiditis in TINU syndrome.
3D printing as a pedagogical tool for teaching normal human anatomy: a systematic review
Authors: Brumpt Eléonore , Bertin Eugénie , Tatu Laurent , Louvrier Aurélien 
Published: October 2023

Abstract
Background
Three-dimensional-printed anatomical models (3DPAMs) appear to be a relevant tool due to their educational value and their feasibility. The objectives of this review were to describe and analyse the methods utilised for creating 3DPAMs used in teaching human anatomy and for evaluating its pedagogical contribution.

Methods
An electronic search was conducted on PubMed using the following terms: education, school, learning, teaching, learn, teach, educational, three-dimensional, 3D, 3-dimensional, printing, printed, print, anatomy, anatomical, anatomically, and anatomic. Data retrieved included study characteristics, model design, morphological evaluation, educational performance, advantages, and disadvantages.

Results
Of the 68 articles selected, the cephalic region was the most studied (33 articles); 51 articles mentioned bone printing. In 47 articles, the 3DPAM was designed from CT scans. Five printing processes were listed. Plastic and its derivatives were used in 48 studies. The cost per design ranged from 1.25 USD to 2800 USD. Thirty-seven studies compared 3DPAM to a reference model. Thirty-three articles investigated educational performance. The main advantages were visual and haptic qualities, effectiveness for teaching, reproducibility, customizability and manipulability, time savings, integration of functional anatomy, better mental rotation ability, knowledge retention, and educator/student satisfaction. The main disadvantages were related to the design: consistency, lack of detail or transparency, overly bright colours, long printing time, and high cost.

Conclusion
This systematic review demonstrates that 3DPAMs are feasible at a low cost and effective for teaching anatomy. More realistic models require access to more expensive 3D printing technologies and substantially longer design time, which would greatly increase the overall cost. Choosing an appropriate image acquisition modality is key. From a pedagogical viewpoint, 3DPAMs are effective tools for teaching anatomy, positively impacting the learning outcomes and satisfaction level. The pedagogical effectiveness of 3DPAMs seems to be best when they reproduce complex anatomical areas, and they are used by students early in their medical studies.
Complete sources of cluster variation on the risk of under-five malaria in Uganda: a multilevel-weighted mixed effects logistic regression model approach
Authors: Natuhamya Charles , Makumbi Fredrick , Mukose Aggrey David , Ssenkusu John M. 
Published: October 2023

Abstract
Background
Malaria, a major cause of mortality worldwide is linked to a web of determinants ranging from individual to contextual factors. This calls for examining the magnitude of the effect of clustering within malaria data. Regrettably, researchers usually ignore cluster variation on the risk of malaria and also apply final survey weights in multilevel modelling instead of multilevel weights. This most likely produces biased estimates, misleads inference and lowers study power. The objective of this study was to determine the complete sources of cluster variation on the risk of under-five malaria and risk factors associated with under-five malaria in Uganda.

Methods
This study applied a multilevel-weighted mixed effects logistic regression model to account for both individual and contextual factors.

Results
Every additional year in a child’s age was positively associated with malaria infection (AOR = 1.42; 95% CI 1.33–1.52). Children whose mothers had at least a secondary school education were less likely to suffer from malaria infection (AOR = 0.53; 95% CI 0.30–0.95) as well as those who dwelled in households in the two highest wealth quintiles (AOR = 0.42; 95% CI 0.27–0.64). An increase in altitude by 1 m was negatively associated with malaria infection (AOR = 0.98; 95% CI 0.97–0.99). About 77% of the total variation in the positive testing for malaria was attributable to differences between enumeration areas (ICC = 0.77; p < 0.001).

Conclusions
Interventions towards reducing the burden of under-five malaria should be prioritized to improve individual-level characteristics compared to household-level features. Enumeration area (EA) specific interventions may be more effective compared to household specific interventions.
Uniformly convergent extended cubic B-spline collocation method for two parameters singularly perturbed time-delayed convection-diffusion problems
Authors: Negero Naol Tufa 
Published: October 2023

AbstractThis work proposes a uniformly convergent numerical scheme to solve singularly perturbed parabolic problems of large time delay with two small parameters. The approach uses implicit Euler and the exponentially fitted extended cubic B-spline for time and space derivatives respectively. Extended cubic B-splines have advantages over classical B-splines. This is because for a given value of the free parameter$$ \lambda $$λthe solution obtained by the extended B-spline is better than the solution obtained by the classical B-spline. To confirm the correspondence of the numerical methods with the theoretical results, numerical examples are presented. The present numerical technique converges uniformly, leading to the current study of being more efficient.