bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the hospital bed in hospital-onset Clostridioides difficile: A retrospective study with mediation analysis
Authors: Witt Lucy S. , Howard-Anderson Jessica , Prakash-Asrani Radhika , Overton Elizabeth , Jacob Jesse T. 
Published: December 2023

AbstractObjective:To determine whether residing in a hospital bed that previously held an occupant with Clostridioides difficile increases the risk of hospital-onset C. difficile infection (HO-CDI).Methods:In this retrospective cohort study, we used a real-time location system to track the movement of hospital beds in 2 academic hospitals from April 2018 to August 2019. We abstracted patient demographics, clinical characteristics, and C. difficile polymerase chain reaction (PCR) results from the medical record. We defined patients as being exposed to a potentially “contaminated” bed or room if, within the preceding 7 days from their HO-CDI diagnosis, they resided in a bed or room respectively, that held an occupant with C. difficile in the previous 90 days. We used multivariable logistic regression to determine whether residing in a contaminated bed was associated with HO-CDI after controlling for time at risk and requiring intensive care. We assessed mediation and interaction from a contaminated hospital room.Results:Of 25,032 hospital encounters with 18,860 unique patients, we identified 237 cases of HO-CDI. Exposure to a contaminated bed was associated with HO-CDI in unadjusted analyses (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.4–2.31) and adjusted analyses (OR, 1.5; 95% CI, 1.2–2.0). Most of this effect was due to both mediation from and interaction with a contaminated hospital room.Conclusions:Residing in a hospital bed or room that previously had a patient with C. difficile increases the risk of HO-CDI. Increased attention to cleaning and disinfecting the healthcare environment may reduce hospital transmission of C. difficile.
The Impact of Dobbs on US Graduate Medical Education
Authors: Pasha Amirala S. , Breitkopf Daniel , Glaser Gretchen 
Published: December 2023

AbstractThe Dobbs decision will directly affect patients and reproductive rights; it will also impact patients indirectly in many ways, one of which will be changes in the physician workforce through its impact on graduate medical education. Current residency accreditation standards require training in all forms of contraception in addition to training in the provision of abortion. State bans on abortions may diminish access to training as approximately half of obstetrics and gynecology residency programs are in states with significant abortion restrictions. The Dobbs decision creates numerous hurdles for trainees and their programs. Trainees in restrictive states will have to travel to learn in a different program in a protective state. As training opportunities diminish, potentially leading to a decline in clinical skills, knowledge, and experience in the provision of abortion, the rate of complications and maternal mortality are likely to rise. This will likely have a disproportionately negative effect on preexisting disparities in reproductive health fueled by a longstanding history of systemic racism and inequities. This work aims to both define the looming problem in abortion training created by Dobbs and propose solutions to ensure that an adequate workforce is available in the future to serve patient needs.
Decolonizing African Mental Health Laws: A Case for Kenya
Authors: Juma Paul Ochieng , Ngwena Charles 
Published: December 2023

AbstractThe aim of this article is to use a decolonial approach to interrogate Kenya's laws and policies that compel the admission and treatment of persons with psychosocial disabilities. Against the backdrop of the colonization of Africa, the article appraises the historical development of Kenyan mental health laws. It critically analyses domestic policies, legislation, court decisions and the Constitution as they apply to admission to healthcare facilities of persons with psychosocial disabilities and to the freedom to decide about treatment, in order to reveal the persistence of coloniality. It highlights gaps in the protection of equality, dignity and liberty. It also draws on pertinent provisions of the Convention on the Rights of Persons with Disabilities as a juridical method for translating a decolonial agenda into a normative framework. Ultimately, the article proposes a framework for decolonizing Kenya's mental health laws and policies.
Prevalence of body-focused repetitive behaviors in a diverse population sample – rates across age, gender, race and education
Authors: Moritz Steffen , Scheunemann Jakob , Jelinek Lena , Penney Danielle , Schmotz Stella , Hoyer Luca , Grudzień Dominik , Aleksandrowicz Adrianna 
Published: December 2023

AbstractBackgroundPrevalence estimates for body-focused repetitive behaviors (BFRBs) such as trichotillomania differ greatly across studies owing to several confounding factors (e.g. different criteria). For the present study, we recruited a diverse online sample to provide estimates for nine subtypes of BFRBs and body-focused repetitive disorders (BFRDs).MethodsThe final sample comprised 1481 individuals from the general population. Several precautions were taken to recruit a diverse sample and to exclude participants with low reliability. We matched participants on gender, race, education and age range to allow unbiased interpretation.ResultsWhile almost all participants acknowledged at least one BFRB in their lifetime (97.1%), the rate for BFRDs was 24%. Nail biting (11.4%), dermatophagia (8.7%), skin picking (8.2%), and lip-cheek biting (7.9%) were the most frequent BFRDs. Whereas men showed more lifetime BFRBs, the rate of BFRDs was higher in women than in men. Rates of BFRDs were low in older participants, especially after the age of 40. Overall, BFRBs and BFRDs were more prevalent in White than in non-White individuals. Education did not show a strong association with BFRB/BFRDs.DiscussionBFRBs are ubiquitous. More severe forms, BFRDs, manifest in approximately one out of four people. In view of the often-irreversible somatic sequelae (e.g. scars) BFRBs/BFRDs deserve greater diagnostic and therapeutic attention by clinicians working in both psychology/psychiatry and somatic medicine (especially dermatology and dentistry).
Task-dependent consequences of disfluency in perception of native and non-native speech
Authors: Houghton Zachary , Kato Misaki , Baese-Berk Melissa , Vaughn Charlotte 
Published: December 2023

AbstractSilent pauses are a natural part of speech production and have consequences for speech perception. However, studies have shown mixed results regarding whether listeners process pauses in native and non-native speech similarly or differently. A possible explanation for these mixed results is that perceptual consequences of pauses differ depending on the type of processing that listeners engage in: a focus on the content/meaning of the speech versus style/form of the speech. Thus, the present study examines the effect of silent pauses of listeners’ perception of native and non-native speech in two different tasks: the perceived credibility and the perceived fluency of the speech. Specifically, we ask whether characteristics of silent pauses influence listeners’ perception differently for native versus non-native speech, and whether this pattern differs when listeners are rating the credibility versus the fluency of the speech. We find that while native speakers are rated as more fluent than non-native speakers, there is no evidence that native speakers are rated as more credible. Our findings suggest that the way a non-native accent and disfluency together impact speech perception differs depending on the type of processing that listeners are engaged in when listening to the speech.
CO2‐Undersaturated Melt Inclusions From the South West Indian Ridge Record Surprisingly Uniform Redox Conditions
Authors: Moussallam Yves , Georgeais Guillaume , Rose‐Koga Estelle F. , Koga Kenneth T. , Hartley Margaret E. , Scaillet Bruno , Oppenheimer Clive , Peters Nial 
Published: December 2023

AbstractThe behavior of Fe3+ during mantle partial melting strongly influences the oxidation state of the resulting magmas, with implications for the evolution of the atmosphere's oxidation state. Here, we challenge a prevailing view that low‐degree partial melts are more oxidized due to the incompatible behavior of Fe3+. Our study is based on measurements of Fe3+/∑Fe along with major, minor, trace and volatile elements in olivine‐ and plagioclase‐hosted melt inclusions of CO2 undersaturated mantle melts in South West Indian Ridge lava. These inclusions record minimum entrapment pressures equivalent to depths up to 10 km below the seafloor, record magma ascent rates of 0.03–0.19 m/s, and display exceptionally high CO2/Ba, CO2/Rb, and CO2/Nb ratios, indicative of a CO2‐rich mantle source. Accounting for fractional crystallization, we find a uniform melt oxidation state (with an Fe3+/ΣFe at 0.140 ± 0.005 at MgO = 10 wt.%) that displays no systematic variation with major, minor, volatile or trace element contents, thus providing no evidence for a relationship between the degree of partial melting and Fe3+/ΣFe. This can be explained by efficient buffering of Fe3+/∑Fe and fO2 of mid‐ocean ridge basalt melts by their surrounding mantle and/or a decrease in the bulk peridotite‐melt Fe2O3 partition coefficient with increasing partial melting. We conclude that changes in the Earth's upper mantle temperature over geological time need not have affected the oxidation state of volcanic products or of the atmosphere.
Greenhouse Gas Forcing and Climate Feedback Signatures Identified in Hyperspectral Infrared Satellite Observations
Authors: Raghuraman Shiv Priyam , Paynter David , Ramaswamy V. , Menzel Raymond , Huang Xianglei 
Published: December 2023

AbstractGlobal greenhouse gas forcing and feedbacks are the primary causes of climate change but have limited direct observations. Here we show that continuous, stable, global, hyperspectral infrared satellite measurements (2003–2021) display decreases in outgoing longwave radiation (OLR) in the CO2, CH4, and N2O absorption bands and increases in OLR in the window band and H2O absorption bands. By conducting global line‐by‐line radiative transfer simulations with 2003–2021 meteorological conditions, we show that increases in CO2, CH4, and N2O concentrations caused an instantaneous radiative forcing and stratospheric cooling adjustment that decreased OLR. The climate response, comprising surface and atmospheric feedbacks to radiative forcings and unforced variability, increased OLR. The spectral trends predicted by our climate change experiments using our general circulation model identify three bedrock principles of the physics of climate change in the satellite record: an increasing greenhouse effect, stratospheric cooling, and surface‐tropospheric warming.
A Closer Look at the Effects of Lake Area, Aquatic Vegetation, and Double‐Counted Wetlands on Pan‐Arctic Lake Methane Emissions Estimates
Authors: Kyzivat Ethan D. , Smith Laurence C. 
Published: December 2023

AbstractLake methane emissions are commonly upscaled from lake area, with recognition that smaller, non‐inventoried lakes emit more per unit area. There is also growing awareness of the importance of lake aquatic vegetation and potential “double‐counting” with wetlands, but lack of consensus on which is most impactful. Here, we combine high‐resolution data with the comprehensive lake inventory HydroLAKES to rank these three variables based on emissions sensitivity. Including non‐inventoried small lakes <0.1 km2 (+30 [range: 9.0 to 82]% change) is greatest, followed by double‐counting (−20 [−11 to −34]%) and lake aquatic vegetation (+14 [2.7 to 43]%). Significantly, emissions from non‐inventoried lakes contribute far less than the ∼40% previously determined globally through statistical area extrapolation. We produce a first pan‐Arctic estimate of lake aquatic vegetation in 1.37 million km2 of lakes, but after correcting for persistent double‐counting, its net effect is to decrease emissions estimates by 9%. Thus, previous global emissions estimates are likely too high.
Characterization of the Spatial Distribution of the Thermodynamic Phase Within Mixed‐Phase Clouds Using Satellite Observations
Authors: Coopman Q. , Tan I. 
Published: December 2023

AbstractModels assume that mixed‐phase clouds consist of uniformly mixed ice crystals and liquid cloud droplets when observations have shown that they consist of clusters, or “pockets,” of ice crystals and liquid cloud droplets. We characterize the spatial distribution of cloud phase over the Arctic and the Southern Ocean using active satellite observations and determine the relative importance of collocated meteorological parameters and aerosols from reanalysis to predict how uniformly mixed mixed‐phase clouds are for the first time. We performed a multi‐linear regression fit to the data set to predict the spatial distribution of the ice and liquid pockets. Contrary to what models suggest, mixed‐phase clouds are rarely perfectly homogeneous. Our results suggest that high temperatures are associated with homogeneously mixed ice and liquid pockets. We also find that a high mixing ratio of black carbon is associated with heterogeneously mixed ice and liquid pockets.
Constitutive Behavior of Olivine Gouge Across the Brittle‐Ductile Transition
Authors: Barbot Sylvain , Zhang Lei 
Published: December 2023

AbstractThe bottom of the lithosphere is characterized by a thermally controlled transition from brittle to ductile deformation. While the mechanical behavior of rocks firmly within the brittle and ductile regimes is relatively well understood, how the transition operates remains elusive. Here, we study the mechanical properties of pure olivine gouge from 100 to 500°C under 100 MPa pore‐fluid pressure in a triaxial deformation apparatus as a proxy for the mechanical properties of the upper mantle across the brittle‐ductile transition. We describe the mechanical data with a rate‐, state‐, and temperature‐dependent constitutive law with multiple thermally activated deformation mechanisms. The stress power exponents decrease from 70 ± 10 in the brittle regime to 17 ± 3 and 4 ± 2 in the semi‐brittle and ductile regimes, respectively. The mechanical model consistently explains the mechanical behavior of olivine gouge across the brittle‐ductile transition, capturing the gradual evolution from cataclasis to crystal plasticity.
Numerical Modeling Prediction of Vegetation Trajectories Under Different Flow Regimes in New Zealand Braided Rivers
Authors: Stecca Guglielmo , Hicks D. Murray , Measures Richard , Henderson Roddy 
Published: December 2023

AbstractWe use two‐dimensional physics‐based numerical modeling to study multi‐decadal evolution of vegetation and morphology under different flow regimes in real‐world gravel‐bed braided rivers. To assess model realism, we focus on two rivers in Canterbury (New Zealand) that, despite having been subjected to the introduction of similar invasive vegetation species in the last ∼100 years, show very different trajectories of vegetation presence due to their different flow regimes: the Lower Waitaki River and the Waimakariri River. The former, featuring a naturally damped flow regime—and having experienced further artificial flow damping due to hydropower generation from the 1930s, experienced vegetation encroachment; while the latter, featuring a flashy flow regime, retains an unvegetated braided planform. We propose an innovative calibration and validation procedure to determine an optimal setup of vegetation parameters that allows the model to robustly reproduce the trajectories of both rivers, thereby proving that the model responds sensibly to different hydrological conditions. Then, we isolate the impact of hydropower‐related flow regime modifications on vegetation encroachment in the Lower Waitaki by running the calibrated model with a natural flow regime that does not feature the effect of hydropower generation, and find that vegetation encroachment would have happened even without flow alteration, albeit to a milder degree. Finally, we apply to simulation results a conceptual framework based on a synthetic parameter that compares the relative strength of hydrological and vegetation controls, and discuss the use of this parameter as a predictor of vegetation presence across flow regimes.
Microzooplankton Grazing Exerts a Strong Top‐Down Control on Unicellular Cyanobacterial Diazotrophs
Authors: Deng Lixia , Cheung Shunyan , Xu Zhimeng , Liu Kailin , Liu Hongbin 
Published: December 2023

AbstractUnicellular cyanobacterial diazotrophs (UCDs) are important nitrogen (N) fixers in marine ecosystems. However, the top‐down control on UCDs is poorly understood, especially for microzooplankton grazing that is often considered to be the dominant loss factor for primary production in oligotrophic oceans. In this study, we investigated the growth and microzooplankton grazing rates of the major UCD taxa (UCYN‐A1, UCYN‐A2/3/4, UCYN‐B, and UCYN‐C) in the South China Sea and the Luzon Strait using a combination of dilution experiments and quantitative PCR. All UCD taxa were actively grazed by microzooplankton, with higher grazing rates occurring in deeper layers of the photic zone. Microzooplankton grazing rates of UCDs were significantly higher than those of phytoplankton as whole, indicating that UCDs might be preferentially grazed by microzooplankton assemblages. The growth and microzooplankton grazing rates of UCDs were almost balanced, suggesting that a substantial amount of the UCD‐derived N is transferred through the food web via microzooplankton in these regions. Our study highlights the importance of microzooplankton grazing in the fate of UCD‐derived N and indicates that UCDs contribute significantly to the plankton food web in oligotrophic oceans where new N is mainly originated from dinitrogen fixation.
A Complete Water Balance of a Rain Garden
Authors: McGauley M. W. , Amur A. , Shakya M. , Wadzuk B. M. 
Published: December 2023

AbstractA bioinfiltration rain garden was retrofitted from an existing traffic island at Villanova University in 2001. It has been monitored continuously since 2003 at a 5‐min timeseries resolution and with instrumentation that would enable a water balance calculation. This 20‐year data set allows for an in‐depth analysis of the hydrologic pathways and management in the rain garden. Using physical equations and modeled data (based on real‐time measurements), a balance of all influent, stored, and effluent water within the rain garden was constructed. Analysis shows the rain garden captures 73.5% of runoff, resulting in a post‐implementation management of 86.2% of all rainfall in its watershed. In comparison to the hydrology of other land covers, implementing the rain garden resulted in the management of 37.6% more rainfall than pre‐implementation, producing a hydrological signature similar to that of cultivated land or low development levels (e.g., 30% impervious). Additionally, with the long data record, several statistical techniques were applied to determine the amount of monitoring needed for a certain level of precision in system performance assessment. For 5% uncertainty, approximately 3 years of continuous data is needed to assess performance. This analysis not only facilitates understanding the function of rain garden systems, but also provides conclusions and methodology for understanding the uncertainty associated with the extent of monitoring performed on these green stormwater infrastructure systems. These findings provide practical knowledge as monitoring of stormwater management infrastructures is becoming a more standard part of their operation.
Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer
Authors: Sudhakaran Meenakshi , Navarrete Tatiana García , Mejía-Guerra Katherine , Mukundi Eric , Eubank Timothy D. , Grotewold Erich , Arango Daniel , Doseff Andrea I. 
Published: December 2023

AbstractTriple-negative breast cancer (TNBC) is characterized by its aggressiveness and resistance to cancer-specific transcriptome alterations. Alternative splicing (AS) is a major contributor to the diversification of cancer-specific transcriptomes. The TNBC transcriptome landscape is characterized by aberrantly spliced isoforms that promote tumor growth and resistance, underscoring the need to identify approaches that reprogram AS circuitry towards transcriptomes, favoring a delay in tumorigenesis or responsiveness to therapy. We have previously shown that flavonoid apigenin is associated with splicing factors, including heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2). Here, we showed that apigenin reprograms TNBC-associated AS transcriptome-wide. The AS events affected by apigenin were statistically enriched in hnRNPA2 substrates. Comparative transcriptomic analyses of human TNBC tumors and non-tumor tissues showed that apigenin can switch cancer-associated alternative spliced isoforms (ASI) to those found in non-tumor tissues. Apigenin preferentially affects the splicing of anti-apoptotic and proliferation factors, which are uniquely observed in cancer cells, but not in non-tumor cells. Apigenin switches cancer-associated aberrant ASI in vivo in TNBC xenograft mice by diminishing proliferation and increasing pro-apoptotic ASI. In accordance with these findings, apigenin increased apoptosis and reduced tumor proliferation, thereby halting TNBC growth in vivo. Our results revealed that apigenin reprograms transcriptome-wide TNBC-specific AS, thereby inducing apoptosis and hindering tumor growth. These findings underscore the impactful effects of nutraceuticals in altering cancer transcriptomes, offering new options to influence outcomes in TNBC treatments.
Accurate prediction of protein assembly structure by combining AlphaFold and symmetrical docking
Authors: Jeppesen Mads , André Ingemar 
Published: December 2023

AbstractAlphaFold can predict the structures of monomeric and multimeric proteins with high accuracy but has a limit on the number of chains and residues it can fold. Here we show that a combination of AlphaFold and all-atom symmetric docking simulations enables highly accurate prediction of the structure of complex symmetrical assemblies. We present a method to predict the structure of complexes with cubic – tetrahedral, octahedral and icosahedral – symmetry from sequence. Focusing on proteins where AlphaFold can make confident predictions on the subunit structure, 27 cubic systems were assembled with a median TM-score of 0.99 and a DockQ score of 0.72. 21 had TM-scores of above 0.9 and were categorized as acceptable- to high-quality according to DockQ. The resulting models are energetically optimized and can be used for detailed studies of intermolecular interactions in higher-order symmetrical assemblies. The results demonstrate how explicit treatment of structural symmetry can significantly expand the size and complexity of AlphaFold predictions.