bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzoquinone‐Lubricated Intercalation in Manganese Oxide for High‐Capacity and High‐Rate Aqueous Aluminum‐Ion Battery
Authors: Meng Huan , Ran Qing , Zhu Mei‐Hua , Zhao Qiang‐Zuo , Han Gao‐Feng , Wang Tong‐Hui , Wen Zi , Lang Xing‐You , Jiang Qing 
Published: January 2024

AbstractAqueous aluminum‐ion batteries are attractive post‐lithium battery technologies for large‐scale energy storage in virtue of abundant and low‐cost Al metal anode offering ultrahigh capacity via a three‐electron redox reaction. However, state‐of‐the‐art cathode materials are of low practical capacity, poor rate capability, and inadequate cycle life, substantially impeding their practical use. Here layered manganese oxide that is pre‐intercalated with benzoquinone‐coordinated aluminum ions (BQ‐AlxMnO2) as a high‐performance cathode material of rechargeable aqueous aluminum‐ion batteries is reported. The coordination of benzoquinone with aluminum ions not only extends interlayer spacing of layered MnO2 framework but reduces the effective charge of trivalent aluminum ions to diminish their electrostatic interactions, substantially boosting intercalation/deintercalation kinetics of guest aluminum ions and improving structural reversibility and stability. When coupled with Zn50Al50 alloy anode in 2 m Al(OTf)3 aqueous electrolyte, the BQ‐AlxMnO2 exhibits superior rate capability and cycling stability. At 1 A g−1, the specific capacity of BQ‐AlxMnO2 reaches ≈300 mAh g−1 and retains ≈90% of the initial value for more than 800 cycles, along with the Coulombic efficiency of as high as ≈99%, outperforming the AlxMnO2 without BQ co‐incorporation.
A Systems Approach to Study Collagen Type I Self‐Assembly: Kinetics and Morphology
Authors: Vena María Paula , van Hazendonk Laura S. , van Zyl Willem , Tuinier Remco , Friedrich Heiner 
Published: January 2024

AbstractCollagen type I, the main component of the extracellular matrix in vertebrates, is widely used in tissue engineering applications. This is on account that collagen molecules can self‐assemble under certain conditions into 3D fibrillar hydrogels. Although there is an extensive body of literature studying collagen self‐assembly, there is a lack of systematic understanding on how different experimental factors, such as pH and temperature, and their cumulative effects guide the self‐assembly process. In this work, a comprehensive workflow to study the interactive effects of several assembly parameters on the collagen self‐assembly process is implemented. This workflow consists of: 1) efficient statistical sampling based on Design of Experiments, 2) high‐throughput and automated data collection and 3) automated data analysis. This approach enables to screen several parameters simultaneously and derive a set of mathematical equations that link parameters with the kinetics and morphological aspects of collagen self‐assembly, and can be used to design collagen constructs with predefined characteristics.
A new early water frog (Telmatobius) from the Miocene of the Bolivian Altiplano
Authors: Gómez Raúl O. , Ventura Tomás , Turazzini Guillermo F. , Marivaux Laurent , Flores Rubén Andrade , Boscaini Alberto , Fernández‐Monescillo Marcos , Quispe Bernardino Mamani , Prámparo Mercedes B. , Fauquette Séverine , Martin Céline , Münch Philippe , Pujos François , Antoine Pierre‐Olivier 
Published: January 2024

AbstractWe describe the new frog Telmatobius achachila sp. nov. from the late Middle to earliest Late Miocene of Achiri, based on a partial skeleton found at 3960 m above sealevel in the Bolivian Altiplano. This skeleton, attributed to a male adult, constitutes the first documented fossil record of the speciose living genus Telmatobius, endemic to the Andean Cordillera and the Altiplano. Phylogenetic analysis confirms the new species as being part of the crown group, and diverging both later than the T. verrucosus group and earlier than the T. bolivianus, T. marmoratus and T. macrostomus groups. Coupled with its accurate stratigraphic provenance and age, this phylogenetic position provides a relevant calibration point for timing the evolutionary history of these highland, mostly aquatic frogs. The skeleton of T. achachila indicates that several of the osteological peculiarities of extant Telmatobius were already acquired at c. 12 Ma, including some that might be linked to their aquatic lifestyle. Together with mixed montane–rainforest pollen vegetation uncovered in the same level, this fossil specimen further provides key data enabling a more accurate reconstruction of ancestral habitats and elevation ranges of Telmatobius, agreeing with the previously postulated conditions in which these water frogs might have first evolved. Ultimately, this discovery adds to the sparse evidence of a humid tropical Bolivian Altiplano just prior to: (1) the Late Miocene uplift pulse of the Central Altiplano; and (2) the drastic climate deterioration that occurred from Late Miocene time onward, leading to the harsh highland‐steppe environments reigning there today.
Learners' Perceived Development of Spoken Grammar Awareness after Corpus‐Informed Instruction: An Exploration of Learner Diaries
Authors: Jones Christian , Oakey David 
Published: January 2024

AbstractDeveloping spoken grammar awareness is a crucial first step in fostering noticing habits (Schmidt, 1990) in second language learners. Classroom instruction using corpus‐informed materials is an ideal way to assist this development, given that these materials are based on research which informs us about the most frequent forms and uses of spoken grammar and thus materials can help us to make frequent forms more salient to learners. However, as Badger (2018) notes, few studies seek to investigate what students actually notice outside of the classroom, following instruction. In this qualitative study, we aimed to address this gap by giving four intermediate learners instruction sessions using corpus‐informed materials to teach three aspects of spoken grammar which corpora show are very frequent (vague language, ellipsis, and discourse markers). Following instruction, learner diaries were submitted over a three‐week period to track (a) whether learners noticed the spoken grammar forms focused upon during the instruction in their day‐to‐day conversations in the UK, (b) whether they used any of the forms, and (c) the extent to which they perceived that this awareness helped them to have more successful conversations. The diaries were supported by a qualitative questionnaire administered 2 weeks after the final diary was submitted. Results show that learners reported noticing the forms in a variety of conversations, although this awareness was not always accurate. They also reported making some use of the forms themselves and the general perception was that the language taught was useful to them.
What is Psychodrama?
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractPsychodrama therapists believe in the idea of spontaneously creative human beings. Mental disorders are understood as blockages or deficits in the patients’ inner creativity. Psychodrama originated from Moreno’s experience at the Impromptu Theatre in Vienna in 1921. A gentle, beautiful actress who today can be believed to have suffered from a borderline organization had unexpectedly developed uncontrollable anger outbursts in her new marriage. Moreno then had the actress enact the roles of street girls and witches in the Impromptu Theatre. As a result, the actress gained ego control over her anger outbursts in her marriage in everyday life. Her outbursts became less frequent and shorter, and sometimes she would laugh even before having her anger outburst. On the basis of this experience, Moreno developed a causal psychotherapy of psychoses from 1936 onwards (Moreno 1939). Later, he also developed therapy for people with neurosis (Moreno 1945b). According to Moreno (1979, p. 77), the playful transition through the absurdity of neurotic or psychotic patterns helps patients to experience the “true second time, which liberates from the first”. Moreno was so fascinated that he had it written on his tombstone in Vienna: “Here lies the one who brought laughter to psychiatry.”
The Pathogenesis of Mental Illnesses, Diagnostics, and Therapy Planning
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractThe pathological concept of psychodrama therapy is not based on clinical symptoms, but on the different conflict qualities lived out by the patient in everyday life and the level of their conflict processing. These determine the severity and nature of the mental disorder and allow for appropriate planning of psychotherapy, counselling, or coaching. They are indicative of certain psychodramatic methods, for example, therapeutic work with psychodramatic dialogue with role reversal or work on rigid defense patterns (ego states).
Trauma-Related Disorders
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractIn order to achieve success in addressing post-traumatic disorders, all psychotherapy methods must deal with the dissociation and flashbacks of these patients in a disorder-specific manner. The patient should learn to free himself from flashbacks in psychological crises through self-stabilization techniques. When narrating a traumatizing situation, he should reflect on what he would have needed in the situation instead. He should rewrite the traumatizing situation into a coping fairy tale. The basis of trauma processing is the dissolution of dissociation through the focused external role change between four different metacognitive processes - the patient’s ego in the control and information space, his ego in the observation and narration space, his ego in the interaction space between perpetrator and victim, and his ego in a safe place. In this way, the patient dissolves his metacognitive confusion. He gains ego control over his dysfunctional self-regulation in the as-if mode of play. Psychodramatic acting in the as-if mode is more healing than purely verbal therapy. This is because the patient differentiates and completes the cognitive thought content in the traumatizing situation in psychodramatic action on the psychosomatic level of sensorimotor patterns of action, physical sensations, and affect. Or he completes the psychosomatic level of experience with the associated linguistic terms and thoughts to form a meaningful narrative. The disorder-specific psychodramatic action methods qualitatively enhance the depth psychological, behavioral, and systemic psychotherapy of people with post-traumatic disorders.
Obsessive–Compulsive Disorders
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractThe disorder-specific psychodrama therapy for obsessive-compulsive disorders begins by developing the patient’s self at the symptom level. The patient symbolizes his current obsessive thoughts (his sadistic superego), as a ‘tormenting spirit’ to which he is exposed, with a chair and a hand puppet on the object level. The compulsive actions are symbolized with another chair as self-protection against the threat of the ‘tormenting spirit’. As a doppelganger, the therapist empowers the patient to develop a relationship with his ‘tormenting spirit’ in a progressive way on the level of play, similar to child therapy, and thus to gain ego control over his masochistic self-censorship. At some point, the patient discovers on his own the inner conflicts that cause his obsessive-compulsive symptoms. The basis of the therapy is the resolution of the patient’s metacognitive confusion through separate external symbolization of the three involved metacognitive processes (ego-states) with chairs. These are his masochistic, self-injurious thinking, his self-protection through adaptation, and his healthy adult thinking. The presented action methods can qualitatively enrich the depth psychological, behavioral, and systemic therapy psychotherapy of obsessive-compulsive disorders.
Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?
Authors: Witz Andréa , Dardare Julie , Betz Margaux , Gilson Pauline , Merlin Jean-Louis , Harlé Alexandre 
Published: January 2024

AbstractThe origin of metastases is a topic that has sparked controversy. Despite recent advancements, metastatic disease continues to pose challenges. The first admitted model of how metastases develop revolves around cells breaking away from the primary tumor, known as circulating tumor cells (CTCs). These cells survive while circulating through the bloodstream and subsequently establish themselves in secondary organs, a process often referred to as the “metastatic cascade”. This intricate and dynamic process involves various steps, but all the mechanisms behind metastatic dissemination are not yet comprehensively elucidated. The “seed and soil” theory has shed light on the phenomenon of metastatic organotropism and the existence of pre-metastatic niches. It is now established that these niches can be primed by factors secreted by the primary tumor before the arrival of CTCs. In particular, exosomes have been identified as important contributors to this priming. Another concept then emerged, i.e. the “genometastasis” theory, which challenged all other postulates. It emphasizes the intriguing but promising role of cell-free DNA (cfDNA) in metastasis formation through oncogenic formation of recipient cells. However, it cannot be ruled out that all these theories are intertwined. This review outlines the primary theories regarding the metastases formation that involve CTCs, and depicts cfDNA, a potential second player in the metastasis formation. We discuss the potential interrelationships between CTCs and cfDNA, and propose both in vitro and in vivo experimental strategies to explore all plausible theories.
Glycogen Synthase Kinase-3β Inhibitor VP3.15 Ameliorates Neurogenesis, Neuronal Loss and Cognitive Impairment in a Model of Germinal Matrix-intraventricular Hemorrhage of the Preterm Newborn
Authors: Atienza-Navarro Isabel , del Marco Angel , Alves-Martinez Pilar , Garcia-Perez Maria de los Angeles , Raya-Marin Alvaro , Benavente-Fernandez Isabel , Gil Carmen , Martinez Ana , Lubian-Lopez Simon , Garcia-Alloza Monica 
Published: January 2024

AbstractAdvances in neonatology have significantly reduced mortality rates due to prematurity. However, complications of prematurity have barely changed in recent decades. Germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most severe complications of prematurity, and these children are prone to suffer short- and long-term sequelae, including cerebral palsy, cognitive and motor impairments, or neuropsychiatric disorders. Nevertheless, GM-IVH has no successful treatment. VP3.15 is a small, heterocyclic molecule of the 5-imino-1,2,4-thiadiazole family with a dual action as a phosphodiesterase 7 and glycogen synthase kinase-3β (GSK-3β) inhibitor. VP3.15 reduces neuroinflammation and neuronal loss in other neurodegenerative disorders and might ameliorate complications associated with GM-IVH. We administered VP3.15 to a mouse model of GM-IVH. VP3.15 reduces the presence of hemorrhages and microglia in the short (P14) and long (P110) term. It ameliorates brain atrophy and ventricle enlargement while limiting tau hyperphosphorylation and neuronal and myelin basic protein loss. VP3.15 also improves proliferation and neurogenesis as well as cognition after the insult. Interestingly, plasma gelsolin levels, a feasible biomarker of brain damage, improved after VP3.15 treatment. Altogether, our data support the beneficial effects of VP3.15 in GM-IVH by ameliorating brain neuroinflammatory, vascular and white matter damage, ultimately improving cognitive impairment associated with GM-IVH.
Acceptability of self-administered antigen test for COVID-19 in the Philippines
Authors: Yang Jayne Eunice U. , Jackarain Faisal H. , de Vergara Tisha Isabelle M. , Santillan Joshua F. , Reyes Patrick Wincy C. , Arellano Ma Cecilia Victoria B. , Garcia Jainor Timothy U. , Samonte Sheena Jasley G. , Marfori Anne Julienne G. , Guerrero Anna Melissa S. 
Published: January 2024

Abstract

Objectives
In response to the Omicron surge in early 2022, the HTA Philippines evaluated the acceptability of Filipinos in using self-administered antigen tests (SAAgTs) as part of COVID-19 HTAs in the Philippines.

Methods
Scoping review from literature databases was initially conducted to identify preset codes in the use of SAAgT. Preset codes were used to establish the questions for focus group discussions (FGDs). Semi-structured questionnaires were created through Delphi technique. FGDs with four stakeholder groups (i.e., nine healthcare workers [HCWs], seven representatives of at-risk groups, six economic frontliners, and seven representatives of micro–small–medium-sized enterprises) were conducted.

Results
Discomfort in being a target of stigma and being prescribed an “illness identity” when suspected or confirmed COVID-19-positive, along with lack of confidence to perform self-test, caused hesitancy in self-testing among participants. The need for subsidies for test kits from the government or employers was emphasized to increase its accessibility. Having a designated access point and reporting system for SAAgT was highlighted to avoid nepotism (padrino system attributed to debt of gratitude), inequitable distribution, and lapses in reporting. A participatory approach to education was perceived as crucial to reduce any misconceptions associated with the use of SAAgT.

Conclusions
All FGD groups expressed favorable reviews on the implementation of SAAgT because it can potentially reduce the burden of health facility-administered tests. These findings were considered by the HTA Council in the recommendation of SAAgT as part of the overarching national strategies for the diagnosis and screening of COVID-19.
The Interannual Wintertime Climate Modes Over Mid‐High Latitude Eurasia and Their Climate Impacts
Authors: Zhang Xinyou , Sun Xuguang , Yuan Shuai , Zhang Zhiqi , Yang Xiu‐Qun , Fang Jiabei 
Published: January 2024

AbstractEurasian teleconnection pattern (EU) and its two variants (EU1 and EU2) are the representative wintertime atmospheric teleconnections over Eurasian continent. They are mainly indicative of the local features and closely related to other teleconnection patterns. What are the major interannual climate modes over mid‐high latitude Eurasia in boreal winter is still an open question. With the ERA5 reanalysis data sets after removing the linear impact of El Niño‐Southern Oscillation (ENSO), three wintertime climate modes over mid‐high latitude Eurasia are identified by the first three empirical orthogonal function (EOF) modes of the anomalous relative tendency (ART) of 500 hPa geopotential height. They approximately explain 75% of the interannual variance in total. The three climate modes have combined features of EU‐like patterns with Arctic Oscillation (AO), North Atlantic Oscillation (NAO) and West Atlantic (WA) teleconnections, respectively, and they are named EU‐AO, EU‐NAO and EU‐WA climate modes accordingly. All the three climate modes originate mainly from the North Atlantic and demonstrate clear Rossby wave trains downstream to East Asia along the great circle route, and they can be primarily stimulated and maintained by positive air‐sea feedback over North Atlantic regarding to the obvious North Atlantic tripole‐like sea surface temperature patterns. Interannual climate variations over the most Eurasian continent are strongly linked to and well reproduced by the three ENSO‐independent climate modes, which can be applied as the important signals for monitoring and predicting winter interannual climate variabilities over mid‐high latitude Eurasia.
The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function
Authors: Di Marco Giulia , Gherardi Gaia , De Mario Agnese , Piazza Ilaria , Baraldo Martina , Mattarei Andrea , Blaauw Bert , Rizzuto Rosario , De Stefani Diego , Mammucari Cristina 
Published: January 2024

AbstractMitoKATP is a channel of the inner mitochondrial membrane that controls mitochondrial K+ influx according to ATP availability. Recently, the genes encoding the pore-forming (MITOK) and the regulatory ATP-sensitive (MITOSUR) subunits of mitoKATP were identified, allowing the genetic manipulation of the channel. Here, we analyzed the role of mitoKATP in determining skeletal muscle structure and activity. Mitok−/− muscles were characterized by mitochondrial cristae remodeling and defective oxidative metabolism, with consequent impairment of exercise performance and altered response to damaging muscle contractions. On the other hand, constitutive mitochondrial K+ influx by MITOK overexpression in the skeletal muscle triggered overt mitochondrial dysfunction and energy default, increased protein polyubiquitination, aberrant autophagy flux, and induction of a stress response program. MITOK overexpressing muscles were therefore severely atrophic. Thus, the proper modulation of mitoKATP activity is required for the maintenance of skeletal muscle homeostasis and function.
Secretomics reveals hormone-therapy of breast cancer may induce survival by facilitating hypercoagulation and immunomodulation in vitro
Authors: Augustine Tanya N. , Buthelezi Sindisiwe , Pather Kyrtania , Xulu Kutlwano R. , Stoychev Stoyan 
Published: January 2024

AbstractTumour cell haematogenous dissemination is predicated on molecular changes that enhance their capacity for invasion and preparation of the pre-metastatic niche. It is increasingly evident that platelets play an essential role in this transformation. The systemic nature of signalling molecules and extravascular factors that participate in mediating platelet-tumour cell interactions led to the development of an in vitro co-culture using whole blood and breast tumour cells, allowing us to decipher the impact of hormone-therapy on tumour cells and associated changes in the plasma proteome. Using mass spectrometry, we determined dysregulation of proteins associated with maintaining an invasive tumour phenotype. Tumour changes in genes associated with EMT and survival were documented. This is postulated to be induced via tumour cell interactions with the coagulatory and immune systems. Results highlight tumour cell adaptability to both treatment and blood resulting in a pro-tumorigenic response and a hypercoagulatory state. We illustrate that the breast cancer cell secretome can be altered by hormone-therapy, subject to the tumour subphenotype and linked to platelet activation. More sophisticated co-culture systems are required to recapitulate these interactions to better understand tumorigenesis. Moreover, deeper plasma profiling, using abundant protein depleted and/or vesicle enriched strategies, will likely reveal additional secretory proteins related to tumour cell-platelet interactions.