bluuebunny/crossref_metadata_2025_split huggingface dataset:
DETECÇÃO DE BACTÉRIAS PSICROTRÓFICAS E PARÂMETROS DE QUALIDADE DO LEITE CRU REFRIGERADO EM TANQUE COMUNITÁRIO
Authors: Cotrim Jeislanny Alves , Rocha Vivianne Cambuí Figueiredo , Pereira Mirian Alves , Costa Mérida Layara Xavier , Aquino Aureluci Alves de 
Published: October 2023

O leite é um alimento com grande valor nutricional, o que o torna um excelente meio de cultura para diversos grupos de microrganismos, que podem alterar sua qualidade físico-química e inocuidade. Comumente, os produtores não dispõem de tecnologias apropriadas no processo de produção para melhorar a qualidade e segurança do produto. Portanto, é imprescindível avaliar as condições higiênico-sanitárias do leite produzido, almejando a produção de um alimento com qualidade, consolidando a fabricação de produtos lácteos seguros aos consumidores e em consonância com a legislação vigente. Nesse contexto, o presente trabalho objetivou analisar as condições higiênicos sanitárias do leite cru retirado de forma manual e armazenado em um tanque de resfriamento comunitário, localizado no distrito de Mutans, Guanambi, Bahia, por meio da contagem de bactérias psicrotróficas. Posteriormente às análises preliminares, foi efetivada a capacitação dos produtores de leite, de modo que eles pudessem conciliar os conhecimentos acerca da legislação, normas fiscais e sanitárias e o “saber-fazer” da ordenha tradicional, a fim de minimizar a contaminação por essas bactérias e os respectivos desdobramentos, tendo em perspectiva a qualidade do leite e dos produtos lácteos. Para os parâmetros físico-químicos, foram realizadas análises da prova de densidade, crioscopia, gordura, extrato seco total e extrato seco desengordurado, alizarol, proteína e lactose. Em relação à qualidade microbiológica, foi realizada análise para contagem padrão em placas de bactérias aeróbias psicrotróficas. Em relação aos resultados das análises físico-químicas, não foram identificadas irregularidades nos teores médios de gordura, extrato seco total, extrato seco desengordurado, proteína e lactose, ademais, apresentaram resultados negativos para o teste de alizarol. Quanto aos padrões microbiológicos, após a capacitação dos produtores, foi perceptível uma redução em relação à contaminação por bactérias psicrotróficas. Portanto, desponta como necessária a implementação de boas práticas agropecuárias durante toda a cadeia de produção leiteira, desde a obtenção, passando pelo armazenamento e transporte do leite cru até o tanque de resfriamento.
FREQUENCY OF BONE MARROW INVOLVEMENT IN PYREXIA OF UNKNOWN ORIGIN
Authors: Farrukh Sarah , Ambareen Hamid  , Sobia Ashraf  , Rafeeda Maab  , Arsala Rashid  , Raana Akhtar  
Published: October 2023

The definition of pyrexia of unknown origin (PUO) dates back to 1961; it was described as a persistent fever above 38.3°C (100°F) that evades diagnosis for at least 3 weeks, including 1 week of investigation in hospital.(1) The causes of PUO can be considered in four categories: infective, inflammatory, neoplastic and miscellaneous. The relative prominence of each category has changed over time, with an increasing proportion of patients who remain undiagnosed, which may be up to 51% of cases.(2) In cases where bone involvement is suspected, bone marrow biopsy can serve as a diagnostic tool , for example, myeloproliferative disorders, preleukemias (due to acute myelogenous leukemia), Gaucher’s disease, lymphoma, Erdheim-Chester disease, miliary tuberculosis, disseminated histoplasmosis, multicentric Castleman’s disease, Whipple’s disease, or typhoid/enteric fever.(3) A relationship between pyrexia of unknown origin and utilizing bone marrow biopsy as a diagnostic modality will be an eye opener for the clinicians. It will stress them to incorporate bone marrow biopsy as a part and parcel of the investigations. This study will also help to know the current spectrum of diseases causing PUO in patients in this region.It will help the clinicians in better assessment of the patients and expedite the diagnostic procedure that will ultimately decrease the misery of the patients.
Comparison Between Chlorhexidine Gluconate and Povidone Iodine In Preventing Surgical Site Infection In Laparoscopic Cholecystectomy
Authors: Rahman Usman Ali , Iftikhar Muhammad Adil , Ahmed Iftikhar , Ch. Muhammad Atif Niaz  , Butt Maliha Javaid , Humaira Yousaf  
Published: October 2023

Surgical site infection is one of the major postoperative complication resulting in an increase in both morbidity and mortality of the patient. Preoperative patients body surface preparation is one of the major factors in preventing surgical site infection. In this study we compared povidone iodine usually used disinfectant with chlorhexidine gluconate for surgical site infection
MATERIALS & METHODS
It was a cross sectional study conducted at General Surgery ward Gulab Devi Hospital Lahore from January 2021 to December 2022. A total of 200 patients undergoing laparoscopic cholecystectomy were included in this study through purposive sampling and then divided into two groups using lottery methods. In Group A peroperative patients skin preparation was done with 10% povidone iodine while in Group B 4% chlorhexidine gluconate was used for skin preparation. Patients with empyema gall bladder, gall bladder or gut perforation and laparoscopic procedures converted to open were excluded from this study.
RESULTS
In this study mean age of 45.8 ± 10.3 years with range from 25 to 65 years. In Group A mean age was 45.7 ± 10.8 years while in group B it was 45.8 ± 9.8 years. In Group A 12% wound infection was documented while in Group B it was only 4% (P-value 0.03).
CONCLUSION
Many antiseptic solutions are used for patient skin preparation before surgery which includes chlorhexidine gluconate, povidone iodine and alcohol. Among these solutions povidone iodine solution is commonly used. In our study we compared povidone iodine with chlorhexidine gluconate solution which showed less surgical site infection which shows chlorhexidine gluconate solution can be safely replaced with povidone iodine solution for skin preparation.
FACTORS IMPACTING MYOCARDIAL INFARCTION IN YOUNG POPULATION; AN INSTITUTION BASED EXPERIENCE
Authors: Fatima  , Athar Nayeem  , Afia Sarwar  , Atiya Begum  
Published: October 2023

ABSTRACT
Objective: To determine the frequency of contributing factors in Myocardial Infarction in young population
Study design: Descriptive, Cross-sectional study
Study was conducted over a period of six months in Medical Unit-II of Services Hospital, Lahore.
Materials & Methods: A total population of 149 young patients irrespective of their gender with age range from 15 to 45 years and suffering from myocardial infarction were included in this study. Relevant information comprising of presence or absence of Hypertension, Diabetes, Smoking, Dyslipidemia, Obesity, Hyperuricemia, and Family history of these selected cases were recorded in the data collection proforma and patients’ confidentiality was ensured.
Results: Out of 149 patients, 101 (67.79%) were males and 48 (32.21%) were females with male to female ratio of 2.1:1. Age range in this study was from 15 to 45 years with mean age of 34.68 ± 6.93 years. Majority of the patients; 80 (53.69%) were between 30 to 45 years of age. Hypertension was reported in 57 (38.26%), Diabetes Mellitus in 28 (18.79%), smoking in 61 (40.94%), dyslipidemia in 80 (53.69%), obesity in 20 (13.42%), hyperuricemia in 21 (14.09%) and positive family history was seen in 30 (20.13%) patients.
Conclusion: This study concluded that Hypertension, Diabetes, Smoking and Dyslipidemia constitute the common and most important contributing factors of Myocardial Infarction(MI) in young patients aged between 15 to 45 years.
Keywords: Myocardial Infarction, young patients, factors.
Pendampingan Usaha Budidaya Bebek Berbasis Tiga Pilar Peternakan di Kecamatan Cileungsi
Authors: Wicaksana Indrajit , Budiningsih Susilowati , Primadhita Yuridistya 
Published: October 2023

This business assistance is part of productive community service which aims to provide entrepreneurial knowledge in the field of animal husbandry using the three pillars. Partner, namely the Cuan Barokah duck farming business located in Cileungsi District, Bogor. Partner is provided with socialization and business assistance so it can conduct business analysis and find solutions to create increased business. In the aspect of feeding, partner is equipped with knowledge so the feeding process is more efficient. In the managing aspect, partner is provided with easy financial recording training and better sanitary system. In the breeding aspect, partner is trained so it can carry out nurseries independently. The existence of this training is expected to help create an increase in sustainable business capacity on Cuan Barokah duck farming in Cileungsi District, Bogor Regency
Pendampingan Kesehatan Mental Keluarga dalam Upaya Pencegahan Depresi dan Bunuh Diri Pada Ibu Muda di Wilayah Kecamatan Papar
Authors: Hanur Binti Su'aidah , Syah Muhamad Arifudin , Dzulfiqar Febri Ardhi Ahmad 
Published: October 2023

The marriage rate for the 15-19-year-old group in urban areas is lower than in the countryside. This phenomenon has a lot of negative effects especially on teenage girls. The problem arising from early marriage among them is the contribution to the high rate of early divorce and domestic violence. The aim of this dedication to society is to build synergy of the role of stakeholders or related bureaucracy to reduce the depression and suicide rates. The method used in this collaboration is participatory action research (PAR). The impact of the change that can be observed is the presence of a good emotional development demonstrated by the participants in which the participants consciously begin to adapt to their own personal lives. Participants began to be able to accept the shortcomings of their respective partners and focused on parenting as their next generation.
Selective CO2 Reduction to Ethylene Mediated by Adaptive Small‐molecule Engineering of Copper‐based Electrocatalysts
Authors: Chen Shenghua , Ye Chengliang , Wang Ziwei , Li Peng , Jiang Wenjun , Zhuang Zechao , Zhu Jiexin , Zheng Xiaobo , Zaman Shahid , Ou Honghui , Lv Lei , Tan Lin , Su Yaqiong , Ouyang Jiang , Wang Dingsheng 
Published: October 2023

AbstractElectrochemical CO2 reduction reaction (CO2RR) over Cu catalysts exhibits enormous potential for efficiently converting CO2 to ethylene (C2H4). However, achieving high C2H4 selectivity remains a considerable challenge due to the propensity of Cu catalysts to undergo structural reconstruction during CO2RR. Herein, we report an in situ molecule modification strategy that involves tannic acid (TA) molecules adaptive regulating the reconstruction of a Cu‐based material to a pathway that facilitates CO2 reduction to C2H4 products. An excellent Faraday efficiency (FE) of 63.6 % on C2H4 with a current density of 497.2 mA cm−2 in flow cell was achieved, about 6.5 times higher than the pristine Cu catalyst which mainly produce CH4. The in situ X‐ray absorption spectroscopy and Raman studies reveal that the hydroxyl group in TA stabilizes Cuδ+ during the CO2RR. Furthermore, theoretical calculations demonstrate that the Cuδ+/Cu0 interfaces lower the activation energy barrier for *CO dimerization, and hydroxyl species stabilize the *COH intermediate via hydrogen bonding, thereby promoting C2H4 production. Such molecule engineering modulated electronic structure provides a promising strategy to achieve highly selective CO2 reduction to value‐added chemicals.
In vitro and in silico analyses reveal the interaction between LysM receptor‐like kinase3 of Solanum tuberosum and the carbohydrate elicitor Riclin octaose
Authors: Wang Hongyang , Zhang Ruixin , Hu Junpeng , Fu Renjie , Li Jing 
Published: October 2023

AbstractAs a carbohydrate elicitor, Riclin octaose (Rioc) activates the pattern‐triggered immunity of Solanum tuberosum L., while how the plant perceives Rioc is unknown. Here, a pattern recognition receptor StLYK3 (LysM receptor‐like kinase3) whose transcription level was significantly up‐regulated after Rioc elicitation was investigated in vitro and in silico. The nucleotide that encoded the ectodomain of StLYK3 (StLYK3‐ECD) was heterologously expressed in the Pichia pastoris strain GS115. The purified StLYK3‐ECD had the molecular weight of 25.08 kDa and pI of 5.69. Afterwards interaction between StLYK3‐ECD and Rioc was analyzed by isothermal titration calorimetry. The molar ratio of ligand to receptor, dissociation constant, and enthalpy were 1.28 ± 0.04, 26.7 ± 3.1 μM, and −45.0 ± 1.8 kJ mol−1, respectively. Besides, molecular dynamics results indicated that StLYK3‐ECD contained three carbohydrate‐binding motifs and the first two motifs probably contributed to the interaction with Rioc via hydrogen bond and van de Waals’ forces. Amino acids containing hydroxyl, amidic, and sulfhydryl groups took the main portion in the docking site. Moreover, replacing the 92nd threonyl (T) of StLYK3‐ECD with valyl (V) resulted in the alteration of the preferred docking site. The dissociation constant drastically increased to 841.6 ± 232.4 μM. In conclusion, StLYK3 was a potential receptor of Rioc.
Enhanced anti‐tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer‐forming interface
Authors: Park Min Yeong , Kim Seoungkyun , Kwon Na Hyun , Moon Giseok , Cha Jaehyun , Kwon Inchan 
Published: October 2023

AbstractThe pressing challenge of cancer's high mortality and invasiveness demands improved therapeutic approaches. Targeting the nutrient dependencies within cancer cells has emerged as a promising approach. This study is dedicated to demonstrating the potential of arginine depletion for cancer treatment. Notably, the focus centers on arginine decarboxylase (RDC), a pH‐dependent enzyme expecting enhanced activity within the slightly acidic microenvironments of tumors. To investigate the effect of a single‐site mutation on the catalytic efficacy of RDC, diverse amino acids, including glycine, alanine, phenylalanine, tyrosine, tryptophan, p‐azido‐phenylalanine, and a phenylalanine analog with a hydrogen‐substituted tetrazine, were introduced at the crucial threonine site (position 39) in the multimer‐forming interface. Remarkably, the introduction of either a natural or a non‐natural aromatic amino acid at position 39 substantially boosted enzymatic activity, while amino acids with smaller side chains did not show the same effect. This enhanced enzymatic activity is likely attributed to the reinforced formation of multimer structures through favorable interactions between the introduced aromatic amino acid and the neighboring subunit. Noteworthy, at slightly acidic pH, the RDC variant featuring tryptophan at position 39 demonstrated augmented cytotoxicity against tumor cells compared to the wild‐type RDC. This attribute aligns with the tumor microenvironment and positions these variants as potential candidates for targeted cancer therapy.
Stage IV breast, colorectal, and lung cancer at diagnosis in adults living with intellectual or developmental disabilities: A population‐based cross‐sectional study
Authors: Mahar Alyson L. , Biggs Kelly , Hansford Rebecca L. , Derksen Shelley , Griffiths Rebecca , Enns Jennifer E. , Dawe David E. , Hallet Julie , Kristjanson Mark , Decker Kathleen , Cobigo Virginie , Shooshtari Shahin , Stirling Morgan , Kelly Christine , Brownell Marni , Turner Donna , Ouellette‐Kuntz Hélène 
Published: October 2023

AbstractBackgroundCancer is a leading cause of death among people living with intellectual or developmental disabilities (IDD). Although studies have documented lower cancer screening rates, there is limited epidemiological evidence quantifying potential diagnostic delays. This study explores the risk of metastatic cancer stage for people with IDD compared to those without IDD among breast (female), colorectal, and lung cancer patients in Canada.MethodsSeparate population‐based cross‐sectional studies were conducted in Ontario and Manitoba by linking routinely collected data. Breast (female), colorectal, and lung cancer patients were included (Manitoba: 2004–2017; Ontario: 2007–2019). IDD status was identified using established administrative algorithms. Modified Poisson regression with robust error variance models estimated associations between IDD status and the likelihood of being diagnosed with metastatic cancer. Adjusted relative risks were pooled between provinces using random‐effects meta‐analyses. Potential effect modification was considered.ResultsThe final cohorts included 115,456, 89,815, and 101,811 breast (female), colorectal, and lung cancer patients, respectively. Breast (female) and colorectal cancer patients with IDD were 1.60 and 1.44 times more likely to have metastatic cancer (stage IV) at diagnosis compared to those without IDD (relative risk [RR], 1.60; 95% confidence interval [CI], 1.16–2.20; RR, 1.44; 95% CI, 1.24–1.67). This increased risk was not observed in lung cancer. Significant effect modification was not observed.ConclusionsPeople with IDD were more likely to have stage IV breast and colorectal cancer identified at diagnosis compared to those without IDD. Identifying factors and processes contributing to stage disparities such as lower screening rates and developing strategies to address diagnostic delays is critical.
Prognostic impact of lymph node involvement and loss of heterozygosity of 1p or 16q in stage III favorable histology Wilms tumor: A report from Children’s Oncology Group Studies AREN03B2 and AREN0532
Authors: Evageliou Nicholas , Renfro Lindsay A. , Geller James , Perlman Elizabeth , Kalapurakal John , Paulino Arnold , Dix David , Eklund Meryle J. , Murphy Andrew J. , Romao Rodrigo L. P. , Ehrlich Peter F. , Varela Carly R. , Vallance Kelly , Fernandez Conrad V. , Dome Jeffrey S. , Mullen Elizabeth A. 
Published: October 2023

AbstractIntroductionThe prognostic impact of positive lymph nodes (LN+) and/or singular loss of heterozygosity (LOH) of 1p or 16q were assessed in children with stage III favorable histology Wilms tumor (FHWT) enrolled on AREN0532 or AREN03B2 alone.Patients and MethodsA total of 635 stage III FHWT vincristine/dactinomycin/doxorubicin (DD4A)–treated patients met inclusion criteria. Event‐free survival (EFS) and overall survival are reported overall and by LN sampling, LN status, LOH 1p, LOH 16q, and a combination of LN status and singular LOH. Patients with unknown or positive combined LOH of 1p and 16q status and AREN03B2‐only patients with unknown outcomes or treatment other than DD4A were excluded.ResultsEFS did not differ by study, supporting pooling. Lack of LN sampling (hazard ratio [HR], 2.12; p = .0037), LN positivity (HR, 2.78; p = .0002), LOH 1p (HR, 2.18; p = .0067), and LOH 16q (HR, 1.72; p = .042) were associated with worse EFS. Compared with patients with both LN– and LOH–, those with negative nodes but positive LOH 1p or 16q and those with LN+ but LOH– for 1p or 16q had significantly worse EFS (HR, 3.05 and 3.57, respectively). Patients positive for both LN and LOH had the worst EFS (HR, 6.33; overall group factor, p < .0001).ConclusionFindings confirm LN+ status as an adverse prognostic factor amplified by presence of singular LOH 1p or 16q, supporting study of intensified therapy for patients with LN+ in combination with singular LOH in a prospective clinical trial.
π‐shaped circularly polarized high‐gain Minkowski fractal antenna for radar applications
Authors: Pandav Subhasish , Sadhukhan Gautam , Das Tanmaya Kumar , Behera Santanu Kumar , Mohanty Madhusmita 
Published: October 2023

SummaryThis article investigates a compact π‐shaped circularly polarized Minkowski fractal antenna (MFA). The proposed radiator is taking a π‐shape with semicircular cuts along the opposite side of the patch with a V‐cut at the bottom. A second‐order Minkowski fractal curve is implemented on the bottom ground plane. The antenna element is powered by a coaxial probe. The asymmetric structure generates two orthogonal modes, which results in circular polarization. A maximum gain response of 7.1 dBic is observed in the impedance band width (IBW) covering 9.7 to 11.2 GHz. The patch is fabricated on substrate RT/Duroid 5880™ (𝜀𝑟=2.2). The antenna has a compact dimension of 0.90λ0 × 0.90λ0 × 0.05λ0 (fr = 10.45 GHz). A good match in the results validates the simulated and measured data in comparison with the existing models from literature with respect to diversity performance, thus making it suitable for radar applications.
[Ru3(CN)3(CO)9]3−:Building Block for Multimetallic Cages
Authors: Wang Ping , Zhang Yu , Woods Toby , Rauchfuss Thomas B. 
Published: October 2023

AbstractA cluster‐ligand is disclosed in the form of [Ru3(CN)3(CO)9]3− ([1]3−). Produced by simple reaction of [Ru3(CO)12] with cyanide, [1]3− serves as a precursor to a series of μ‐CN cages. When treated with [Ru3(CO)12], it readily forms the prism [Ru6(μ‐CN)3(CO)18]3−. With 1.5 equiv. of [Cu(MeCN)4]+ [1]3− reacts to give the expanded prism {Cu3[Ru3(μ‐CN)3(CO)9]2}3−, which features three two‐coordinate Cu(I) centers. Sources of Ni2+ and Fe2+ bind two equivalents of [1]3−, giving the double cages {M[Ru3(μ‐CN)3(CO)9]2}4− (M=Ni, Fe) wherein the central metal is octahedral. The 1 : 1 reaction using [Fe(H2O)6]2+ gave the interpenetrated super‐tetrahedrane {Fe4(μ4‐O)[Ru3(μ‐CN)3(CO)9]4}4−.
Photoredox Synthesis of Silyl Ethers via Radical Coupling of Ketones with Hydrosilanes and [1, 2]‐Brook Rearrangement
Authors: Wang Ting , Wang Guo‐Qin , Zhang Yue , Liu Yuan‐Yuan , Zhang Zheng‐Bing , Han Pan , Jing Lin‐Hai 
Published: October 2023

AbstractAn expedient synthesis of silyl ethers is reported via photocatalytic free radical coupling of ketones with hydrosilanes and subsequent [1, 2]‐Brook rearrangement. This strategy features the advantages of 100 % atom economy, environmental friendliness, easily available starting materials as well as late‐stage functionalization of complex molecules.
Eye movement desensitisation and reprocessing as add‐on treatment to enhanced cognitive behaviour therapy for patients with anorexia nervosa reporting childhood maltreatment: A quasi‐experimental multicenter study
Authors: Rossi Eleonora , Cassioli Emanuele , Cecci Lucia , Arganini Francesca , Martelli Michela , Redaelli Carolina Alberta , Anselmetti Simona , Bertelli Sara , Fernandez Isabel , Ricca Valdo , Castellini Giovanni 
Published: October 2023

AbstractObjectiveThis quasi‐experimental study aimed to compare the outcome of patients with Anorexia Nervosa (AN) reporting moderate/severe childhood maltreatment (CM) treated exclusively with Enhanced Cognitive Behaviour Therapy (CBT‐E) or with CBT‐E plus Eye Movement Desensitisation and Reprocessing (EMDR).MethodA total of 75 patients with AN reporting moderate/severe CM were initially assessed regarding body mass index (BMI), general and eating disorder (ED)‐specific psychopathology, and dissociative symptoms, and re‐evaluated after 40 CBT‐E sessions (T1). Then, 18 patients received EMDR, whereas the others were placed on a waiting list and continued CBT‐E. T2 assessment was performed after 20–25 sessions of EMDR or CBT‐E. A control group of 67 patients without CM was also enroled and treated with CBT‐E.ResultsContrary to patients without CM, neither of the traumatised groups improved in BMI, general and ED psychopathology, or dissociation at T1. However, at T2, both traumatised groups improved in BMI and ED‐specific psychopathology, with the CBT + EMDR group demonstrating greater improvements. Moreover, only the CBT + EMDR group improved in general psychopathology and dissociative symptoms. The reduction of ED symptoms in traumatised patients was mediated by the amelioration of dissociation.DiscussionThe addition of EMDR to CBT‐E may benefit patients with AN reporting moderate/severe CM.