bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of colorimetric and electrochemical (Easy Touch GCU Meter) methods for determination of blood uric acid in clinical practice in patients with gout and hyperuricemia (data from a pilot study)
Authors: Eliseev M. S. , Panina E. V. , Zheliabina O. V. 
Published: October 2023

Hyperuricemia (HU) is a condition caused by an increase in serum uric acid (UA) levels above 360 μmol/l. Often HU is asymptomatic, but under the influence of genetic and environmental factors, attacks of peripheral arthritis (gout) may occur. Remission of gout is achieved by normalization of UA serum levels, which can be determined by a colorimetric or electrochemical method, although the latter is not currently commonly used in clinical practice to control UA levels. Objective: to compare the standard colorimetric and electrochemical methods (Easy Touch GCU Meter) for monitoring UA levels. Material and methods. 30 gout patients were included in the study. This group included subjects with current/anamnestic asymptomatic HU andpatients with a confirmed diagnosis of gout (ACR/EULAR 2015 criteria). The examination included a general examination, history taking, and laboratory testing. The determination of UA level by the colorimetric method in venous blood serum was performed no later than 5 minutes after collection, and the determination of UA level in fresh whole capillary blood from the fingertip by the electrochemical method (Easy Touch GCU Meter) – immediately after collection. Results and discussion. The average values of UA blood level determined by the two compared methods differed by 13.9 μmol/l (3.9 % with respect to the colorimetric method). The high value of the correlation coefficient (r = 0.86) indicates a close linear relationship between the compared results and their good agreement. The method is also applicable in patients with achieved normouricemia. Conclusions. The method of electrochemical determination of UA level in subjects with HU and gout can be used in real clinical practice for self-monitoring.
Evaluation of efficacy and safety of combined use of nonsteroidal anti-inflammatory drugs and extended release tolperisone in patients with ankle injuries
Authors: Sadykov R. I. , Akhtyamov I. F. , Shoshorina K. T. , Lapshina S. A. 
Published: October 2023

Ankle capsular ligamentous apparatus damage is one of the most common problems. Ankle injuries account for one-fifth of all lower extremity sports injuries. More than 81 % of acute ankle injuries are treated conservatively, with the rate of unsatisfactory results after this treatment ranging from 2 to 36.9 %. Objective: to evaluate the efficacy and safety of the combined use of aceclofenac (Airtal) and tolperisone (Mydocalm Long) in patients with acute ankle ligament injuries. Material and methods. Sixty patients aged 18 to 65 years with acute ankle ligament injury of grade II according to Kannus and Renstrom, with pain intensity in the joint on a visual analogue scale (VAS) ≥ 50 mm, who had no contraindications for the use of these drugs, participated in the study. Patients in the main group (n = 30) received aceclofenac 100 mg in powder form 2 times daily and tolperisone 450 mg in tablets once daily for 14 days. Patients in the comparison group (n = 30) received only aceclofenac 100 mg in powder form 2 times daily for 14 days. The efficacy of therapy was assessed by pain dynamics according to VAS and functional abilities according to the Foot and Ankle Ability Measure (FAAM) questionnaire, which included the Activities of Daily Living (ADL) subscale and the Sports subscale. To assess safety, laboratory tests were performed at visits 1 and 4, and adverse events (AEs) were assessed at visits 2, 3, and 4. Results and discussion. Combined use of aceclofenac and tolperisone in patients with acute ankle ligament injuries resulted in more clinically significant pain reduction and improvement in functional indicators than aceclofenac monotherapy. In the combination therapy group, after completion of treatment on day 15, the severity of pain decreased by 94.8%, the increase in the score on the ADL scale was 62.9 % and on the Sports scale – 70.4 %. In the monotherapy group, pain intensity decreased by 85.1 %, the increase in the score on the ADL scale reached 40.7% and onthe Sports scale – 43.4 %. Throughout the study period, the medications were well tolerated, and no AEs were recorded. Conclusion. The combined use of aceclofenac and tolperisone in patients with acute ankle ligament damage leads to a reduction in pain intensity in a short time, significantly improves indicators of functional activity, promotes a faster return to sports activities, and at the same time has a favourable safety profile.
Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices
Authors: Pasetes Lauren N. , Rosendahl‐Garcia Kathleen M. , Goel Namni 
Published: October 2023

AbstractSince short sleep duration adversely affects cardiovascular (CV) health, we investigated the effects of exposures to total sleep deprivation (TSD), and baseline (BL) and recovery (REC) sleep on CV measures. We conducted a 5‐day experiment at months 2 and 4 in two separate studies (N = 11 healthy adults; 5 females). During these repeated experiments, CV measures [stroke volume (SV), cardiac index (CI), systemic vascular resistance index (SVRI), left ventricular ejection time, heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) and mean arterial pressure (MAP)] were collected at three assessment time points after: (1) two BL 8 h time‐in‐bed (TIB) sleep opportunity nights; (2) a TSD night; and (3) two REC 8‐10 h TIB nights. CV measures were also collected pre‐study. TSD significantly increased SV and CI, and decreased SVRI, with large effect sizes, which importantly were reversed with recovery, indicating these measures are possible novel biomarkers for assessing the adverse consequences of TSD. Pre‐study SV, CI, SVRI, HR, SBP, and MAP measures also significantly associated with TSD CV responses at months 2 and 4 [Pearson's r: 0.615–0.862; r2: 0.378–0.743], indicating they are robust correlates of future TSD CV responses. Our novel findings highlight the critical impact of sleep on CV health across time.
Flight muscle size reductions and functional changes following long‐distance flight under variable humidity conditions in a migratory warbler
Authors: Groom Derrick J. E. , Black Betsy , Deakin Jessica E. , DeSimone Joely G. , Lauzau M. Collette , Pedro Bradley P. , Straight Chad R. , Unger Kimberly P. , Miller Mark S. , Gerson Alexander R. 
Published: October 2023

AbstractBird flight muscle can lose as much as 20% of its mass during a migratory flight due to protein catabolism, and catabolism can be further exacerbated under dehydrating conditions. However, the functional consequences of exercise and environment induced protein catabolism on muscle has not been examined. We hypothesized that prolonged flight would cause a decline in muscle mass, aerobic capacity, and contractile performance. This decline would be heightened for birds placed under dehydrating environmental conditions, which typically increases lean mass losses. Yellow‐rumped warblers (Setophaga coronata) were exposed to dry or humid (12 or 80% relative humidity at 18°C) conditions for up to 6 h while at rest or undergoing flight. The pectoralis muscle was sampled after flight/rest or after 24 h of recovery, and contractile properties and enzymatic capacity for aerobic metabolism was measured. There was no change in lipid catabolism or force generation of the muscle due to flight or humidity, despite reductions in pectoralis dry mass immediately post‐flight. However, there was a slowing of myosin–actin crossbridge kinetics under dry compared to humid conditions. Aerobic and contractile function is largely preserved after 6 h of exercise, suggesting that migratory birds preserve energy pathways and function in the muscle.
Adopting the International Consensus on ANA Patterns (ICAP) classification for reporting: the experience of Italian clinical laboratories
Authors: Infantino Maria , Bizzaro Nicola , de Melo Cruvinel Wilson , Chan Edward K.L. , Andrade Luis E.C. 
Published: October 2023

Abstract
The indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) is still considered the reference method to detect anti-nuclear antibodies (ANA) because of its high sensitivity and represents a relevant tool for the diagnosis of autoimmune rheumatic diseases. During the last decade, the International Consensus on ANA Patterns (ICAP) initiative promoted harmonization and understanding of HEp-2 IFA staining pattern nomenclature, as well as promoting their use in patient care by providing interpretation for HEp-2 IFA test results. In conjunction with a nationwide survey on the evolution of autoantibody diagnostics in autoimmune rheumatic diseases, we focused on the adherence of the Italian laboratories to the ICAP nomenclature analyzing its lights and shadows. The recent ICAP-oriented report, largely used today among Italian laboratories, also represents a further step in harmonizing and improving communication with the clinicians, adding value to laboratory findings and helping with critical clinical decisions.
An optimal transport-based characterization of convex order
Authors: Wiesel Johannes , Zhang Erica 
Published: October 2023

Abstract
For probability measures

μ
,
ν

\mu ,\nu

, and

ρ

\rho

, define the cost functionals

C

(

μ
,
ρ

)

≔

sup

π
∈
Π

(

μ
,
ρ

)

∫

⟨

x
,
y

⟩

π

(

d
x
,
d
y

)

and

C

(

ν
,
ρ

)

≔

sup

π
∈
Π

(

ν
,
ρ

)

∫

⟨

x
,
y

⟩

π

(

d
x
,
d
y

)

,

C\left(\mu ,\rho ):= \mathop{\sup }\limits_{\pi \in \Pi \left(\mu ,\rho )}\int \langle x,y\rangle \pi \left({\rm{d}}x,{\rm{d}}y)\hspace{1.0em}{\rm{and}}\hspace{1em}C\left(\nu ,\rho ):= \mathop{\sup }\limits_{\pi \in \Pi \left(\nu ,\rho )}\int \langle x,y\rangle \pi \left({\rm{d}}x,{\rm{d}}y),

where

⟨

⋅
,
⋅

⟩

\langle \cdot ,\cdot \rangle

denotes the scalar product and

Π

(

⋅
,
⋅

)

\Pi \left(\cdot ,\cdot )

is the set of couplings. We show that two probability measures

μ

\mu

and

ν

\nu

on

R

d

{{\mathbb{R}}}^{d}

with finite first moments are in convex order (i.e.,

μ

≼

c

ν

\mu {\preccurlyeq }_{c}\nu

) iff

C

(

μ
,
ρ

)

≤
C

(

ν
,
ρ

)

C\left(\mu ,\rho )\le C\left(\nu ,\rho )

holds for all probability measures

ρ

\rho

on

R

d

{{\mathbb{R}}}^{d}

with bounded support. This generalizes a result by Carlier. Our proof relies on a quantitative bound for the infimum of

∫

f
d
ν
−

∫

f
d
μ

\int f{\rm{d}}\nu -\int f{\rm{d}}\mu

over all 1-Lipschitz functions

f

f

, which is obtained through optimal transport (OT) duality and the characterization result of OT (couplings) by Rüschendorf, by Rachev, and by Brenier. Building on this result, we derive new proofs of well known one-dimensional characterizations of convex order. We also describe new computational methods for investigating convex order and applications to model-independent arbitrage strategies in mathematical finance.
Synthesis and characterization of Pluronic F-127-coated titanium dioxide nanoparticles synthesized from extracts of Atractylodes macrocephala leaf for antioxidant, antimicrobial, and anticancer properties
Authors: Almaimani Riyad A. 
Published: October 2023

Abstract
Globally, nanotechnology is generating significant interest because of its promise in a wide range of industries. The most commonly used nanoparticles are titanium dioxide nanoparticles (PF-127 coated TiO2 NPs), which can be formulated with physical, chemical, and environmental factors. The establishment of an economical and environmentally beneficial method for its fabrication is due to increasing concerns about human health impacts. In this exploration, green Pluronic F-127 (PF-127) coated TiO2 NPs using leaf extracts of Atractylodes macrocephala have been formulated and studied through various methods. PF-127 coated TiO2 NPs were 60 nm large and a polygonal rutile-type crystalline structure was observed. Moreover, the NPs’ antimicrobial capacity against several pathogens was investigated. The cytotoxicity of the NPs against HEp-2, KB, and Vero cell lines was assessed using the MTT test. Increased antimicrobial potential of PF-127 coated TiO2 NPs against several pathogens was noted. Furthermore, NPs displayed remarkable antioxidant activity, which increased with concentration. The NPs exhibited significant cytotoxic effects against HEp-2 and KB cell lines but failed to demonstrate toxicity against Vero cells. This is indicative of their cytotoxic potential against cancer cell lines and non-toxic nature towards healthy cells. This indicates that PF-127 coated TiO2 NPs possess beneficial antimicrobial and antitumor properties.
Microstructure and electrochemical behaviour of laser clad stainless steel 410 substrate with stainless steel 420 particles
Authors: Natarajan Jeyaprakash , Manickam Bhuvanesh Kumar , Yang Che-Hua , Periyasamy Susila 
Published: October 2023

Abstract
Stainless steel (SS) 410 is widely used in many engineering applications such as turbines, nuclear reactor components and seamless pipes due to its superior mechanical properties i.e., high mechanical strength, creep resistance and ductility. Corrosion resistance is an important property which is required for these components to reduce the material degradation from the surface. In the present study, an investigation has been made to enhance the electrochemical behavior of SS410 by depositing SS420 particles using the laser cladding technique. The hardness measured through nano-indentation tests and microstructure of the resulting surface were analysed. Also, electrochemical studies were performed on laser clad specimens with different durations such as 0 h, 8 h, 14 h and 36 h. The improvements in corrosion resistance were analysed using polarization curves and electrochemical impedance spectroscopy (EIS). Further, the morphology and roughness of the corroded surface were analysed. The results showed that a closely packed acicular structure was formed through cladding, which improved the nanohardness compared to the base material. In addition, the clad specimen with 14 h test duration exhibited excellent corrosion resistance amongst the other specimens. The morphological analysis of the corroded specimen revealed the formation of oxides which is indentified to be a major reason for improved corrosion resistance.
The influence of rheology in the fabrication of ceramic-based scaffold for bone tissue engineering
Authors: Bagwan Jameer K. , Ahuja Bharatkumar B. 
Published: October 2023

Abstract
Bone tissue is the second most affected organ in the human body after blood. Tissue engineering is the area whereby a scaffold is used to regenerate the lost bone. However, the scaffold’s effectiveness is primarily based on the material and the fabrication process. The patient-specific structures are affected because of the fabrication process used to fabricate the scaffold as per requirement. In this regard, rheology plays an important role in the fabrication of the patient-specific scaffold, and it is a study of the flow of ink. This primarily affects both the conventional as well as the non-conventional fabrication processes. In this paper, the scaffold and bone tissue engineering, the different fabrication processes, and the importance of the rheological characterization are presented. In addition to this, the rheological properties of the developed HA/β-TCP composite slurry are evaluated for the extrusion-based additive manufacturing process. The developed ink’s rheological properties show that the flow behavior index of about 0.0497 ± 0.009, minimum flow stress required to make the ink flow of about 51.076 Pa at a strain rate of 0.111 %, and shape retention upto 75 % after 175 s are obtained. Also, different orientations are 3D printed using the developed slurry.
Martin Luther King, Jr. and Apocalyptic Thought
Authors: Bowens Lisa 
Published: October 2023

Abstract
Apocalyptic literature has been designated as “crisis literature” and as a “form of protest against society” by some interpreters. This essay explores Martin Luther King Jr.’s reception and use of apocalyptic literature and thought in his sermons and writings. In doing so, it examines how King appropriates this literature as well as apocalyptic motifs to speak about the significance of African American history and to protest racism in American society. Such an analysis provides insight into the ongoing importance of the protest and crisis features of these apocalyptic texts. Moreover, the apocalyptic facets of King’s work have never been analyzed from a biblical studies perspective and this essay highlights the significance of these dimensions for his social justice work.
The association between maternal colonization with Group B Streptococcus and infectious morbidity following transcervical Foley catheter-assisted labor induction
Authors: Ben-David Alon , Meyer Raanan , Mazaki-Tovi Shali 
Published: October 2023

Abstract

Objectives
To determine whether maternal colonization with Group B Streptococcus increases the risk for infectious morbidity following transcervical Foley catheter-assisted cervical ripening.

Methods
A retrospective cohort study comparing infectious morbidity and other clinical outcomes by Group B Streptococcus colonization status between all women with singleton pregnancies who underwent Foley catheter-assisted cervical ripening labor induction at a single tertiary medical center during 2011–2021. Multivariable logistic regression explored the relationship between Group B Streptococcus colonization to adverse outcomes while adjusting for relevant clinical variables.

Results
A total of 4,409 women were included of whom 886 (20.1 %) were considered Group B Streptococcus carriers and 3,523 (79.9 %) were not. Suspected neonatal sepsis rate was similar between Group B Streptococcus carriers and non-carriers (5.2 vs. 5.0 %, respectively, p=0.78). Neonatal sepsis was confirmed in 7 (0.02 %) cases, all born to non-carriers. Group B Streptococcus carriers had a higher rate of maternal bacteremia compared to non-carriers (1.2 vs. 0.5 %, respectively, p=0.01). Group B Streptococcus colonization was independently associated with maternal bacteremia (adjusted odds ratio 3.05; 95 %CI 1.39, 6.66).

Conclusions
Group B Streptococcus colonization among women undergoing Foley catheter-assisted cervical ripening does not seem to increase the risk for neonatal infection. However, higher rates of maternal bacteremia were detected.
Analysis of wall-modelled particle/mesh PDF methods for turbulent parietal flows
Authors: Balvet Guilhem , Minier Jean-Pierre , Roustan Yelva , Ferrand Martin 
Published: October 2023

Abstract
Lagrangian stochastic methods are widely used to model turbulent flows.
Scarce consideration has, however, been devoted to the treatment of the near-wall region and to the formulation of a proper wall-boundary condition.
With respect to this issue, the main purpose of this paper is to present an in-depth analysis of such flows when relying on particle/mesh formulations of the probability density function (PDF) model.
This is translated into three objectives.
The first objective is to assess the existing an-elastic wall-boundary condition and present new validation results.
The second objective is to analyse the impact of the interpolation of the mean fields at particle positions on their dynamics.
The third objective is to investigate the spatial error affecting covariance estimators when they are extracted on coarse volumes.
All these developments allow to ascertain that the key dynamical statistics of wall-bounded flows are properly captured even for coarse spatial resolutions.
Polaritonic linewidth asymmetry in the strong and ultrastrong coupling regime
Authors: Canales Adriana , Karmstrand Therese , Baranov Denis G. , Antosiewicz Tomasz J. , Shegai Timur O. 
Published: October 2023

Abstract
The intriguing properties of polaritons resulting from strong and ultrastrong light–matter coupling have been extensively investigated. However, most research has focused on spectroscopic characteristics of polaritons, such as their eigenfrequencies and Rabi splitting. Here, we study the decay rates of a plasmon–microcavity system in the strong and ultrastrong coupling regimes experimentally and numerically. We use a classical scattering matrix approach, approximating our plasmonic system with an effective Lorentz model, to obtain the decay rates through the imaginary part of the complex quasinormal mode eigenfrequencies. Our classical model automatically includes all the interaction terms necessary to account for ultrastrong coupling without dealing with the rotating-wave approximation and the diamagnetic term. We find an asymmetry in polaritonic decay rates, which deviate from the expected average of the uncoupled system’s decay rates at zero detuning. Although this phenomenon has been previously observed in exciton–polaritons and attributed to their disorder, we observe it even in our homogeneous system. As the coupling strength of the plasmon–microcavity system increases, the asymmetry also increases and can become so significant that the lower (upper) polariton decay rate reduction (increase) goes beyond the uncoupled decay rates, γ
− < γ
0,c
< γ
+. Furthermore, our findings demonstrate that polaritonic linewidth asymmetry is a generic phenomenon that persists even in the case of bulk polaritons.
Study on the volatilization behavior of monomer and oligomers in polyamide-6 melt by dynamic film–forming device
Authors: Zhu Xia , Tao Linzhong , Chen Liping , Xiong Siwei , Yang Feihua , Jia Yingbin , Wang Luoxin , Wang Hua 
Published: October 2023

Abstract
In this study, a modified torque rheometer is used to investigate the volatilization behavior of monomer and oligomers in polyamide-6 (PA6) melt under dynamic film–forming conditions with negative pressure. The surface renewal model is employed to simulate the volatilization behavior. The effects of actual processing factors and simulation results on the volatilization behavior of monomer and oligomer are analyzed comparatively. It is found that the monomer and oligomers removal rate increase continuously with increasing temperature, residence time, and rotational speed. And, the cyclic dimer, which is extremely harmful to spinning, can be removed. It is found that the removal of monomer and oligomers continued to increase with increasing temperature, residence time, and spinning speed. Moreover, cyclic dimers, which are extremely harmful to spinning, are also removed. Additionally, it is discovered that the polycondensation reaction of PA6 results in an increase in the molecular weight and viscosity at lower temperatures (250 °C), while a higher temperature (270 °C) and shear rate (150 r/min) cause a reduction in viscosity and molecular weight.