bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimasi Keberhasilan Siswa dalam Pemodelan Data Berbasis Learning Menggunakan Algoritma Support Vector Machine
Authors: Suryani Suryani , Mustakim Mustakim 
Published: December 2023

SMK Negeri 5 Pekanbaru aims to prepare competent graduates who can compete in the global market. The realization of these goals is influenced by student achievement at school. Student achievements determine the ability of students to work in certain fields. Based on observations, it is known that student achievement at SMK Negeri 5 Pekanbaru tend to be low. This is also shown by the data that has been collected through the Curriculum section. Based on the data, there can be extraction using the supervised learning method to make a classification model of student achievements. The supervised learning algorithm used in this research is a Support Vector Machine (SVM). The data used in this study are student's data grade X SMK Negeri 5 Pekanbaru in 2020 totaling 160 data. The classification process is carried out by applying the GridSearch method to find the best kernel to be implemented. Based on the implementation of GridSearch, the kernel to be used is Radial Basis Function (RBF) with Cost (C) and Gamma (?) parameters. Based on 16 experiments with different parameter values, the best classification results are obtained using the value of Cost (C) = 0.1 and the value of Gamma (?) = 0.01, with accuracy values of 94%.
Une économe en Nouvelle-France. Marie de l’Incarnation et les promesses du territoire
Authors: Sribnai Judith 
Published: December 2023

Les écrits de Marie de l’Incarnation mettent en scène différents discours économiques – spirituel, affectif, politique, marchand. C’est d’abord à cette richesse sémantique et conceptuelle que cet article porte attention. Il s’agit, par ailleurs, de montrer le bénéfice heuristique qu’il y a à considérer les liens et des points de rencontre entre ces imaginaires : celui de l’échange profane et sacré, de la transaction marchande et sociale, de la promesse de l’Alliance et de la dette insolvable. Une telle démarche aide notamment à comprendre la façon dont s’est construite et perpétuée une histoire coloniale en Nouvelle-France.
Le saumon à la mayonnaise. Un imaginaire de la dette dans Le Survenant de Germaine Guèvremont
Authors: Bélanger David 
Published: December 2023

Cet article mobilise « l’imaginaire de la dette » comme concept d’analyse économique des oeuvres littéraires. Il s’appuie sur les travaux de l’anthropologue David Graeber, du sociologue Maurizio Lazzarato et, de façon métaphorique, sur un mot d’esprit rapporté par Sigmund Freud. Il défend l’idée selon laquelle l’imaginaire de la dette se configure dans les oeuvres sous le signe de l’ambivalence entre divers régimes de dette (communiste, hiérarchique et d’échange, selon Graeber). Les sujets en dette peinent à s’orienter entre ces régimes qui comportent leur propre morale, leur propre narratif et leur propre grammaire d’interactions. Pour illustrer l’embrayage de ces régimes, Le Survenant (1945) de Germaine Guèvremont fait ici l’objet d’une lecture attentive qui permet de voir à l’oeuvre le conflit entre le régime communiste des obligations et le régime d’échange des dettes.
Henri-Raymond Casgrain. Écrire la vie de Marie de l’Incarnation au xixe siècle
Authors: Ferraro Alessandra 
Published: December 2023

De nombreux textes publiés au xixe siècle en France et au Canada se penchent sur la figure de Marie de l’Incarnation. Le plus souvent, ce sont des biographies rédigées par des membres du clergé rattachés à l’église du Québec, proches de l’ordre des Ursulines, qui appuient le procès en béatification de la missionnaire auprès de Pie IX. Cet article étudie la prolifération de ces ouvrages à l’intérieur d’un triangle géographique et politique transatlantique dont le troisième sommet est Rome. Dans ce mouvement de redécouverte de la future sainte, les différentes Vies, dont celles écrites par l’abbé Casgrain, le « père de la littérature canadienne-française », ne poursuivent pas toutes le même but. Casgrain investit dans l’écriture biographique des enjeux multiples qui pèsent sur la constitution du champ littéraire du Canada français.
Cervical cancer screening improvements with self-sampling during the COVID-19 pandemic
Authors: Elfström Miriam , Gray Penelope Grace , Dillner Joakim 
Published: December 2023

Background:At the onset of the COVID-19 pandemic cervical screening in the capital region of Sweden was canceled for several months. A series of measures to preserve and improve the cervical screening under the circumstances were instituted, including a switch to screening with HPV self-sampling to enable screening in compliance with social distancing recommendations.Methods:We describe the major changes implemented, which were (1) nationwide implementation of HPV screening, (2) switch to primary self-sampling instead of clinician sampling, (3) implementation of HPV screening in all screening ages, and (4) combined HPV vaccination and HPV screening in the cervical screening program.Results:A temporary government regulation allowed primary self-sampling with HPV screening in all ages. In the Stockholm region, 330,000 self-sampling kits were sent to the home address of screening-eligible women, instead of an invitation to clinician sampling. An increase in organized population test coverage was seen (from 54% to 60% in just 1 year). In addition, a national campaign for faster elimination of cervical cancer with concomitant screening and vaccination for women in ages 23–28 was launched.Conclusions:The COVID-19 pandemic necessitated major changes in the cervical cancer preventive strategies, where it can already be concluded that the strategy with organized primary self-sampling for HPV has resulted in a major improvement of population test coverage.Funding:Funded by the Swedish Association of Local Authorities and Regions, the Swedish Cancer Society, the European Union’s Horizon 2020 Research and Innovation Program, the Swedish government, and the Stockholm county.
Transcriptomic and metabolomic differences between banana varieties which are resistant or susceptible to Fusarium wilt
Authors: Tian Dandan , Qin Liuyan , Verma Krishan K. , Wei Liping , Li Jialin , Li Baoshen , Zhou Wei , He Zhangfei , Wei Di , Huang Sumei , Long Shengfeng , Huang Quyan , Li Chaosheng , Wei Shaolong 
Published: December 2023

Background
Fusarium wilt, caused by Fusarium oxysporum f. sp. cubense race 4 (Foc4), is the most lethal disease of bananas in Asia.

Methods
To better understand the defense response of banana to Fusarium wilt, the transcriptome and metabolome profiles of the roots from resistant and susceptible bananas inoculated with Foc4 were compared.

Results
After Foc4 inoculation, there were 172 and 1,856 differentially expressed genes (DEGs) in the Foc4-susceptible variety (G1) and Foc4-resistant variety (G9), respectively. In addition, a total of 800 DEGs were identified between G1 and G9, which were mainly involved in the oxidation-reduction process, cell wall organization, phenylpropanoid biosynthesis, and lipid and nitrogen metabolism, especially the DEGs of Macma4_08_g22610, Macma4_11_g19760, and Macma4_03_g06480, encoding non-classical arabinogalactan protein; GDSL-like lipase; and peroxidase. In our study, G9 showed a stronger and earlier response to Foc4 than G1. As the results of metabolomics, lipids, phenylpropanoids and polyketides, organic acids, and derivatives played an important function in response to Fusarium wilt. More importantly, Macma4_11_g19760 might be one of the key genes that gave G9 more resistance to Foc4 by a lowered expression and negative regulation of lipid metabolism. This study illustrated the difference between the transcriptomic and metabolomic profiles of resistant and susceptible bananas. These results improved the current understanding of host-pathogen interactions and will contribute to the breeding of resistant banana plants.
Comparative Analysis of Various Spider Silks in Regard to Nerve Regeneration: Material Properties and Schwann Cell Response
Authors: Stadlmayr Sarah , Peter Karolina , Millesi Flavia , Rad Anda , Wolf Sonja , Mero Sascha , Zehl Martin , Mentler Axel , Gusenbauer Claudia , Konnerth Johannes , Schniepp Hannes C. , Lichtenegger Helga , Naghilou Aida , Radtke Christine 
Published: December 2023

AbstractPeripheral nerve reconstruction through the employment of nerve guidance conduits with Trichonephila dragline silk as a luminal filling has emerged as an outstanding preclinical alternative to avoid nerve autografts. Yet, it remains unknown whether the outcome is similar for silk fibers harvested from other spider species. This study compares the regenerative potential of dragline silk from two orb‐weaving spiders, Trichonephila inaurata and Nuctenea umbratica, as well as the silk of the jumping spider Phidippus regius. Proliferation, migration, and transcriptomic state of Schwann cells seeded on these silks are investigated. In addition, fiber morphology, primary protein structure, and mechanical properties are studied. The results demonstrate that the increased velocity of Schwann cells on Phidippus regius fibers can be primarily attributed to the interplay between the silk's primary protein structure and its mechanical properties. Furthermore, the capacity of silk fibers to trigger cells toward a gene expression profile of a myelinating Schwann cell phenotype is shown. The findings for the first time allow an in‐depth comparison of the specific cellular response to various native spider silks and a correlation with the fibers’ material properties. This knowledge is essential to open up possibilities for targeted manufacturing of synthetic nervous tissue replacement.
Design Criteria for Architected Materials with Programmable Mechanical Properties Within Theoretical Limit Ranges
Authors: Yin Peng , Li Baotong , Hong Jun , Jing Hui , Li Bang , Liu Honglei , Chen Xiaoming , Lu Yang , Shao Jinyou 
Published: December 2023

AbstractArchitected materials comprising periodic arrangements of cells have attracted considerable interest in various fields because of their unconventional properties and versatile functionality. Although some better properties may be exhibited when this homogeneous layout is broken, most such studies rely on a fixed material geometry, which limits the design space for material properties. Here, combining heterogeneous and homogeneous assembly of cells to generate tunable geometries, a hierarchically architected material (HAM) capable of significantly enhancing mechanical properties is proposed. Guided by the theoretical model and 745 752 simulation cases, generic design criteria are introduced, including dual screening for unique mechanical properties and careful assembly of specific spatial layouts, to identify the geometry of materials with extreme properties. Such criteria facilitate the potential for unprecedented properties such as Young's modulus at the theoretical limit and tunable positive and negative Poisson's ratios in an ultra‐large range. Therefore, this study opens a new paradigm for materials with extreme mechanical properties.
Oral Carbon Monoxide Enhances Autophagy Modulation in Prostate, Pancreatic, and Lung Cancers
Authors: Bi Jianling , Witt Emily , McGovern Megan K. , Cafi Arielle B. , Rosenstock Lauren L. , Pearson Anna B. , Brown Timothy J. , Karasic Thomas B. , Absler Lucas C. , Machkanti Srija , Boyce Hannah , Gallo David , Becker Sarah L. , Ishida Keiko , Jenkins Joshua , Hayward Alison , Scheiflinger Alexandra , Bodeker Kellie L. , Kumar Ritesh , Shaw Scott K. , Jabbour Salma K. , Lira Vitor A. , Henry Michael D. , Tift Michael S. , Otterbein Leo E. , Traverso Giovanni , Byrne James D. 
Published: December 2023

AbstractModulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epidemiological features associated with autophagy inhibition and a positive oncological clinical response, a retrospective analysis of patients is conducted treated with hydroxychloroquine, a known autophagy inhibitor. A direct correlation between smoking status and inhibition of autophagy with hydroxychloroquine is identified. Recognizing that smoking is associated with elevated circulating levels of carbon monoxide (CO), it is hypothesized that supplemental CO can amplify autophagy inhibition. A novel, gas‐entrapping material containing CO in a pre‐clinical model is applied and demonstrated that CO can dramatically increase the cytotoxicity of autophagy inhibitors and significantly inhibit the growth of tumors when used in combination. These data support the notion that safe, therapeutic levels of CO can markedly enhance the efficacy of autophagy inhibitors, opening a promising new frontier in the quest to improve cancer therapies.
Mechanically and Thermally Stable Cathode Electrolyte Interphase Enables High‐temperature, High‐voltage Li||LiCoO2 Batteries
Authors: Wu Daxiong , Zhu Chunlei , Wang Huaping , Huang Junda , Jiang Gaoxue , Yang Yulu , Yang Gaojing , Tang Dongliang , Ma Jianmin 
Published: December 2023

AbstractThe development of high‐energy‐density Li||LiCoO2 batteries is severely limited by the instability of cathode electrolyte interphase (CEI) at high voltage and high temperature. Here we propose a mechanically and thermally stable CEI by electrolyte designing for achieving the exceptional performance of Li||LiCoO2 batteries at 4.6 V and 70 °C. 2,4,6‐tris(3,4,5‐trifluorophenyl)boroxin (TTFPB) as the additive could preferentially enter into the first shell structure of PF6− solvation and be decomposed on LiCoO2 surface at low oxidation potential to generate a LiBxOy‐rich/LiF‐rich CEI. The LiBxOy surface layer effectively maintained the integrity of CEI and provided excellent mechanical and thermal stability while abundant LiF in CEI further improved the thermal stability and homogeneity of CEI. Such CEI drastically alleviated the crack and regeneration of CEI and irreversible phase transformation of the cathode. As expected, the Li||LiCoO2 batteries with the tailored CEI achieved 91.9 % and 74.0 % capacity retention after 200 and 150 cycles at 4.6 and 4.7 V, respectively. Moreover, such batteries also delivered an unprecedented high‐temperature performance with 73.6 % capacity retention after 100 cycles at 70 °C and 4.6 V.
Selective and Efficient CO2 Electroreduction to Formate on Copper Electrodes Modified by Cationic Gemini Surfactants
Authors: Zhang Xiudong , Yan Xupeng , Chen Peng , Zhang Pei , Kang Xinchen , Ma Jun , Chen Chunjun , Han Buxing 
Published: December 2023

AbstractElectroreduction of CO2 into valuable chemicals and fuels is a promising strategy to mitigate energy and environmental problems. However, it usually suffers from unsatisfactory selectivity for a single product and inadequate electrochemical stability. Herein, we report the first work to use cationic Gemini surfactants as modifiers to boost CO2 electroreduction to formate. The selectivity, activity and stability of the catalysts can be all significantly enhanced by Gemini surfactant modification. The Faradaic efficiency (FE) of formate could reach up to 96 %, and the energy efficiency (EE) could achieve 71 % over the Gemini surfactants modified Cu electrode. In addition, the Gemini surfactants modified commercial Bi2O3 nanosheets also showed an excellent catalytic performance, and the FE of formate reached 91 % with a current density of 510 mA cm−2 using the flow cell. Detailed studies demonstrated that the double quaternary ammonium cations and alkyl chains of the Gemini surfactants played a crucial role in boosting electroreduction CO2, which can not only stabilize the key intermediate HCOO* but also provide an easy access for CO2. These observations could shine light on the rational design of organic modifiers for promoted CO2 electroreduction.
Study on quantitative structure–activity relationship of amine surfactants in coal reverse flotation
Authors: Shen Liang , Li Zihan , Gong Jiabao , Liu Lingyun , Qiao Erle , Liu Yifang , Min Fanfei 
Published: December 2023

AbstractWith the deterioration of underground coal quality, hundreds of millions of tons of coal slime in China need to be treated using flotation methods every year. However, the design and selection of coal slurry flotation collectors lack theoretical guidance. In this paper, the quantitative structure–activity relationship (QSAR) model between the molecular structure descriptors of collectors and the flotation recovery and selectivity index is established by using pure kaolinite/clean coal flotation experiments and molecular simulation techniques. Flotation results showed that the flotation recovery rate of kaolinite by collectors with larger head group size, such as DDMAC, DDP, and DTAC, is higher than that of the other collectors with smaller head group size. DDA, DDP, and DD have similar flotation capabilities for clean coal, and their selectivity was slightly better than others. The QSAR model between the molecular structure descriptor and the selectivity index was successfully constructed by combining flotation experiments and molecular simulation results. The reliability of this model has been proven through theoretical analysis and flotation experiments. The molecular simulation results indicate that all eight collectors can advertise on 001 (−) surface of kaolinite, but the final advertisement configuration is different. DDA has less coverage on the surface of kaolinite. When the collector is DDA, the concentration of water molecules near the 001 (−) surface of kaolinite is the highest, indicating that the collector DDA has the weakest effect on improving the hydrophobicity of the 001 (−) surface of kaolinite. DDMAC and DDBAC have the best facilitation to the surface hydrophobicity of kaolinite 001 (−). The research results have theoretical guidance significance for the selection and design of mineral flotation collectors.
Resveratrol‐loaded decellularized ovine pericardium: ECM introduced for tissue engineering
Authors: Khazaei Mozafar , Alizadeh Morteza , Rezakhani Leila 
Published: December 2023

AbstractAn ideal scaffold for skin tissue engineering should have a suitable potential for antibacterial activity, no hemolysis, sufficient porosity for air exchange, water retention capacity, and a suitable swelling rate to maintain tissue moisture. Considering this issue, our study used decellularized ovine pericardial tissue's extracellular matrix (ECM). These scaffolds were decellularized with sodium dodecyl sulfate (SDS) and sodium deoxycholate (SD) detergents along with vacuum methods. Following imaging with scanning electron microscopy (SEM), analysis of the mechanical properties, and the measurement of the amount of DNA, collagen, and glycosaminoglycan (GAG), our study observed that the three‐dimensional (3D) structure of ECM was largely preserved. Resveratrol (RES) 400 µg/µL was loaded into the above scaffold, and analysis revealed that scaffolds containing RES and with vacuum reported higher antibacterial properties, a higher swelling rate, and increased water retention capacity. The biocompatibility and hemocompatibility properties of the above scaffolds also reported a significant difference between methods of decellularization.
Verfügbarkeitsmodell A10/A24: modellbasierte Projektabwicklung über den Lebenszyklus
Authors: Tschickardt Thomas 
Published: December 2023

AbstractDie BIM‐basierte Projektabwicklung im Infrastrukturbau, besonders in Ausführungs‐ und Erhaltungsphasen, befindet sich in der Erprobungsphase. Das Projekt Verfügbarkeitsmodell A10/A24 ist ein nationales Pilotprojekt der DEGES im Auftrag der Autobahn GmbH im Auftrag der Bundesrepublik Deutschland, um Leistungsniveau 1 des Stufenplans Digitales Planen und Bauen umzusetzen. Es ist das erste Projekt, das Planung, Ausführung und Erhaltung nahtlos mit BIM durchführt und somit über bisherige Pilotprojekte hinausgeht. Die Verkehrsfreigabe des Projekts erfolgte am 11. November 2022 zwischen Neuruppin und Pankow. Die Planungs‐ und Ausführungsphase wurde an einem Bauabschnitt kontinuierlich mit BIM umgesetzt. In den nächsten 25 Jahren wird das Erhaltungsmanagement auf Basis des Übergabemodells durchgeführt, inkl. Zustandsdaten, Schäden und Erhaltungsmaßnahmen. Im Folgenden werden Erkenntnisse aus der Implementierung und Umsetzung des BIM‐Projekts vorgestellt.
Validated spectrofluorimetric method for the determination of netilmicin based on its interaction with o‐phthalaldehyde/mercaptoethanol: Evaluation of the method's greenness
Authors: Salem AlSalem Huda , Saad Binkadem Mona , Talal Al‐Goul Soha , Obaydo Reem H. , El Hamd Mohamed A. , Katamesh Noha S. , Abdel‐Lateef Mohamed A. 
Published: December 2023

AbstractIn this study, netilmicin (NTM) was selectively assessed in its dosage forms after a facile derivatization reaction. The proposed approach was based on the interaction between NTM and o‐phthalaldehyde/2‐mercaptoethanol (Roth's reagent). The reaction product was fluorometrically measured at λemission of 434 nm after λexcitation of 338 nm. All reaction conditions for achieving the optimum fluorescence switch‐on activity were visualized and monitored. Moreover, the method was validated under ICH guidelines, and was linear over the range 30–210 ng/ml after plotting netilmicin concentrations against the corresponding fluorescence intensity values. In addition, the selectivity of the developed method was investigated against either the co‐formulated drug (dexamethasone) or a common ophthalmic drop excipient (benzalkonium chloride) without interference from either of them. Furthermore, the developed method was applied to assay netilmicin in various samples of pharmaceutical eye drops with good recovery. Finally, multicriteria greenness and whiteness metrics were used to evaluate the sustainability, greenness, and whiteness of the approach. The applied tools were the AGREE algorithm, the RGB 12 algorithm, and HEXAGON.
Stability indicating reversed‐phase‐high‐performance liquid chromatography method development and validation for pyridostigmine bromide and sodium benzoate in oral solution
Authors: Chintala Vaishnavi 
Published: December 2023

AbstractThe present study focuses on the development of a simple, rapid, specific, and stability‐indicating HPLC method for the simultaneous analysis of pyridostigmine bromide (PGB) and sodium benzoate (SBN) in oral liquid dosage forms. Analytical techniques should enhance sensitivity and specificity for the estimation of pharmaceutical drug products. Stress studies were conducted under various International Conference on Harmonization (ICH) conditions for evaluation. The further optimized HPLC method was validated in accordance with the current ICH guidelines. Chromatographic separation was accomplished using a mobile phase consisting of a 950:50 v/v ratio of perchloric acid buffer and acetonitrile as mobile phase‐A, and 100% acetonitrile as mobile phase‐B. The flow rate is 1.0 mL/min, and the injection volume is 20 μL. Detection of components was carried out at 220 nm for PGB and 228 nm for SBN. The validated HPLC method demonstrated high specificity, with linearity ranging between 24 and 72 μg/mL for PGB and 5.2–15.6 μg/mL for SBN. The correlation coefficient for both drugs exceeded 0.999. The method demonstrated high accuracy, exceeding 97%. In stress studies, PGB was found to be sensitive to alkaline stress conditions. The results reveal the successful applicability of the current method for the estimation of PGB and SBN in its marketed formulation, which can be reasonably inferred to assess other formulation systems.