bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitation of Colonic Cells as Severity Markers in Patients with Irritable Bowel Syndrome
Authors: Rostami-Nejad Mohammad , Miri Mohammad Bagher , Sadeghi Amir , Moradi Afshin , Ehsani-Ardekani Mohammad-Javad , Asadzadeh-Aghdaei Hamid , Safari Mohammad-Taghi , Zali Mohammad Reza 
Published: December 2023

Background: Irritable bowel syndrome (IBS) is the most common gastrointestinal syndrome. Routine histopathology and immunohistochemistry (IHC) evaluations have shown an increase in the number of different inflammatory cells in the colon of IBS patients. In this study, we have compared the number of intraepithelial lymphocytes (IELs), eosinophils, mast cells and CD3+ T cells, in IBS patients and normal subjects. Materials and Methods: In 2016, seventy-nine patients with IBS and seventy-nine healthy subjects who underwent colonoscopy for other non-specific causes and with no pathologic findings, were enrolled in this cross-sectional study. Biopsy specimens obtained from the colon were stained, using IHC methods to determine the number of IELs, eosinophils, mast cells and CD3+ T cells. Quantitative and qualitative variables were compared between the two groups, using a Chi-square test and Studentâ€™s t-test. Results: Seventy-nine patients with IBS, 79.7% females with a mean age of 42.5Â±14.6 years, were recruited, as the case group, and seventy-nine individuals, 51.9% females with a mean age of 39.7Â±18.9 years, were enrolled as controls. The average number of IELs per high power fields (hpf) was found to be higher in the IBS group, and this difference was statistically significant (32.8Â±11.8 vs. 28.6Â±12.9; P=0.034). Also, the mean count/hpf of CD3+ T lymphocytes (23.1Â±7.9 vs. 20.2Â±8.1; P=0.024) and mast cells (7.6Â±3.1 vs. 6.6Â±3.0; P=0.041) were significantly higher in the IBS group, compared to the control group. The number of eosinophils was higher in the IBS group, but the differences were not statistically significant (P=0.066). Conclusion: According to the results, we suggest that analysis of immune cells and IELs in intestinal biopsies might be an appropriate method for diagnosis of IBS.Â [GMJ.2018;7:e1063]
Cytotoxic Effects of Coated Gold Nanoparticles on PC12 Cancer Cell
Authors: Aidun Amir , Zare Marzouni Hadi , Tarkhan Fazel , Shahzamani Kiana , Jahan Tigh Hamid Reza , Malekshahian Sareh , Esmaeil Lashgarian Hamed 
Published: December 2023

Background: The use of gold nanoparticles in medicine and especially in cancer treatment has been of interest to researchers. The effectiveness of this nanoparticle on cells significantly depends on the amount of its entry into the cells. This study was performed to compare the rate and mechanism of effect of gold nanoparticles coated with different amino acid on PC12 cancer cell line.
Materials and Methods: The PC12 cells line were exposed to various concentrations of amino acid coated and uncoated gold nanoparticles (0.5, 2.5 and 5 Î¼M). Cell death rate was determined according to level of Lactate dehydrogenase (LDH) release from cells and MTT assay. In addition cell morphology and the amount of Cellular Reactive oxygen species (ROS) were studied.
Results: The uncoated gold nanoparticles have shown minor effects on cellular life. Gold nanoparticles coated by tryptophan at high concentrations (2.5, 5 and 25Î¼M) increase in cancer cells metabolic activity. Gold nanoparticles coated by Aspartate also produce the largest amount of LDH and ROS in cancer cells and therefore caused of highest rate of apoptosis.
Conclusion: The results showed that the nanoparticles coated with amino acids are affected on cellular metabolism and apoptosis more than uncoated nanoparticles. Also the smallest coated nanoparticles (coated by aspartate) have the most influence and by increasing the size, this effect was reduced.Â [GMJ.2018;7:e1110]
Diagnostic Value of Hepatic Vein Ultrasound in Early Detection of Liver Cirrhosis
Authors: Matinfard Sedighe , Zare Marzouni Hadi , Davachi Behrooz , Rezazadeh Mahdi , Salehi Milani Mahmoud 
Published: December 2023

Background: Cirrhosis is a common disease that destroys liver cells, and it has various etiologies. The early diagnosis of cirrhosis can be effective in improving prognosis.
Considering the availability and affordability of ultrasound devices throughout the world, in this study we evaluated the diagnostic value of hepatic vein ultrasound examination in the early detection of liver cirrhosis.
Materials and Methods: In this study, 45 patients referred to the radiology department of Ghaem Hospital for liver biopsy were evaluated for changes in the hepatic veins under ultrasound with a transducer of 5-7MHz. One piece of the hepatic vein was selected for ultrasound, and the wall of hepatic veins was examined for straightness and uniformity of echogenicity. Subsequently, patients underwent biopsy by ultrasound guide.Â Of all the study subjects, eight patients presented mild chronic hepatitis without fibrosis, four patients were diagnosed with fatty liver, and 33 patients had severe cirrhosis or chronic hepatitis with fibrosis.
Results: Our results showed that hepatitis patients with or without fibrosis had irregular and wavy hepatic vein wall (impairment in straightness) with non-uniform echo (impairment in uniformity of echogenicity). While patients without hepatitis and cirrhosis, but diagnosed with fatty liver, had a smooth and regular hepatic vein wall with a uniform echo.
Conclusion: The present study showed that hepatic vein examination in terms of echogenicity and straightness could be used to diagnose hepatitis, its severity as well as its course towards fibrosis and cirrhosis.Â [GMJ.2018;7:e1140]
Factors Affecting in-stent Restenosis in Patients Undergoing Percutaneous Coronary Angioplasty
Authors: Sajadian Mostafa , Alizadeh Ladan , Ganjifard Mahmoud , Mardani Armin , Ansari Mohammad Ali , Falsoleiman Homa 
Published: December 2023

Percutaneous coronary angioplasty (PCI) and stent implantation are the most common therapeutic strategies for coronary artery stenosis; however, in-stent restenosis (ISR) is one of its important challenges. Although in some studies, coronary artery disease (CAD) factors are deemed to be the causes of ISR, in some others, the relationship between CAD factors and ISR are not observed. Over the past ten years, there has been no review article on factors affecting the ISR. This article aimed to review the possible factors affecting ISR in patients undergoing PCI. This narrative review study was conducted on PubMed, Web of Science, Scopus, and Google Scholar databases between 1 January 1990 and 30 July 2017. After initial screening of 1728 retrieved articles, 1401 articles were excluded to due irrelevancy to the review; and finally, 39 papers were selected for data collection. Our study results showed that the site and length of implanted stent, hypertension and diabetes are the most probable factors affecting ISR. Further studies are required for evaluation of the effect of other possible risk factors such as genetic sequencing, obesity, chronic infections and hemoglobin A1C levels. [GMJ.2018;7:e961]
Â
Trend of Gastric Cancer after Bayesian Correction of Misclassification Error in Neighboring Provinces of Iran
Authors: Pourhoseingholi Mohamad Amin , Baghestani Ahmad Reza , Ashtari Sara , Najafimehr Hadis , Busani Luca , Zali Mohammad Reza 
Published: December 2023

Background: Some errors may occur in the disease registry system. One of them is misclassification error in cancer registration. It occurs because some of the patients from deprived provinces travel to their adjacent provinces to receive better healthcare without mentioning their permanent residence. The aim of this study was to re-estimate the incidence of gastric cancer using the Bayesian correction for misclassification across Iranian provinces. Materials and Methods: Data of gastric cancer incidence were adapted from the Iranian national cancer registration reports from 2004 to 2008. Bayesian analysis was performed to estimate the misclassification rate with a beta prior distribution for misclassification parameter. Parameters of beta distribution were selected according to the expected coverage of new cancer cases in each medical university of the country. Results: There was a remarkable misclassification with reference to the registration of cancer cases across the provinces of the country. The average estimated misclassification rate was between 15% and 68%, and higher rates were estimated for more deprived provinces. Conclusion: Misclassification error reduces the accuracy of the registry data, in turn causing underestimation and overestimation in the assessment of the risk of cancer in different areas. In conclusion, correcting the regional misclassification in cancer registry data is essential for discerning high-risk regions and making plans for cancer control and prevention. [GMJ.2019;8:e1223]Â
Â
Effective Factors of Utilization of Inpatient, Outpatient, Diagnostic, and Pharmaceutical Health Services: A Systematic Review
Authors: Azimzadeh Solmaz , Tabrizi Jafar Sadegh , Nosratnejad Shirin , Farahbakhsh Mostafa , Azami Aghdash Saber , Abdollahi Hossein 
Published: December 2023

Normal";
Utilization is one of the dimensions of equity in health systems. Identifying the factors affecting utilization of health services can be helpful for interventional purposes. This study systematically reviewed the factors affecting the utilization of inpatient, outpatient, diagnostic, and pharmaceutical services. This systematic review was conducted between 2016 and 2017. The search was performed using keywords based on MeSH in valid databases such as Scopus, Embase, ProQuest, ScienceDirect, PubMed, and Web of Science in the fields of title, abstract, and keyword. Related papers published from 2000 to 2017 were searched. First, the retrieved studies were screened and checked for quality; then, the useful data were extracted and analyzed. Out of the 1178 retrieved publications, 20 studies were included in the final analysis. The identified factors were categorized into 5 areas, including demographic (4 items), socioeconomic (13 items), health servicesâ€“related (13 items), health statusâ€“related (7 items), and health insuranceâ€“related factors (2 items), and reported. The findings of this study can be a useful source and a comprehensive body of evidence on the utilization of health services. The results can be used by the policy makers and managers in designing interventions for changing the utilization patterns of health services. [GMJ.2019;8:e1236]

<!-- [if gte mso 10]>
A Short Review on the Relationships Between Nephrolithiasis and Myocardial Infarction
Authors: Karami Hormoz , Maleki Hadi , Baghbeheshti Maryam , Hashemi Mostafa , Rouzbeh Mehrdad , Afkhami Ardakani Mohammad 
Published: December 2023

The interaction between organs is a crucial part of modern medicine. As a very prerequisite to manage a disease, practitioners should have a full awareness of the related organs. Kidney and heart are two vital organs that are closely interconnected in various fields. These two organs have a lot of common risk factors for making a person unhealthy; therefore, if you prevent the disease in one of them, the otherâ€™s morbidity might be alleviated as well. Among them, nephrolithiasis and myocardial infarction (MI) have more risk factors in common, and both could be fatal. Also, these two diseases are important regarding the prevalence, incidence, and burden of disease. Some studies confirm the relationship between MI and nephrolithiasis; however, further researches are needed to discover the exact direction of their relationship. The present review aims to explain the mechanism of MI and nephrolithiasis; clarify the relationship between these two disease based on physiological, pathological, and clinical studies; and propose some solutions for the prevention and treatment of such diseases. [GMJ.2019;8:e1289]
Efficacy of a Persian Herbal Remedy and Electroacupuncture on Metabolic Profiles and Anthropometric Parameters in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial
Authors: Rouhani Maryam , Motavasselian Malihe , Taghipoor Ali , Layegh Parvaneh , Asili Javad , Hamedi Shokouh Sadat , Badiee Avval Shapour 
Published: December 2023

Background: The most prevalent endocrine disorder in women of reproductive age is polycystic ovary syndrome (PCOS). The purpose of this study was to evaluate the efficaciousness of a Persian herbal remedy, as well as electroacupuncture and the combination of them on metabolic profiles and anthropometric parameters in these patients. Materials and Methods: Eighty overweight women with PCOS were randomly divided into four groups. All of them received metformin 1000 mg and the second group received 5 g of herbal medicine per day (main components: Foeniculum vulgare, Urtica dioica, and Daucus carota), the third group were subjected to 20 electroacupuncture sessions, and the fourth group received both therapies. Results: After 12 weeks, the body fat and body mass index decreased the most in the herbal medicine+electroacupuncture group, and waist to hip ratio decreased the most in the electroacupuncture group. A significant decrease was also observed in fasting insulin, homeostasis model assessment of insulin resistance. A significant increase was seen in the quantitative insulin sensitivity check index in all intervention groups, but there was no noteworthy difference in these parameters in the control group. Total cholesterol and low-density lipoprotein cholesterol decreased significantly in the electroacupuncture groups and herbal medicine+electroacupuncture. Also, a significant decrease was observed in triglycerides, aspartate aminotransferase, and alanine aminotransferase in the herbal medicine groups and herbal medicine+electroacupuncture. Conclusion: It is advisable to use this herbal remedy and electroacupuncture for better treatment of metabolic complications and overweight problems in these patients.Â [GMJ.2019;8:e1389]Â
Evaluation of Impacts of Cellular Metabolism on the Migration of Ovarian Cancer Cells by Two in Vitro Assays: A Method Comparison Study
Authors: Salami Siamak , Ghahremani Hossein , Sirati-Sabet Majid 
Published: December 2023

Background: Alteration of metabolic pathways in cancer cells can intensely modulate their migration as an important step in invasion and metastasis. Ketogenic diet showed some contradictory results in cancer patients. In this study the impact of metabolic reprogramming of A2780CP as a model of ovarian cancer stem-like cells on cell migration by two in vitro methods: wound healing and soft agar colony-forming assays. Materials and Methods: short term and long term metabolic reprogramming were done by restriction of glucose to 250mg/L with or without enrichment with beta-hydroxybutyrate (5 milimolar) for 48 hours and 30 days, respectively. Wound healing assay was done and the wound ratio was calculated for 24 and 48 hours. Soft agar colony formation assay was also done in treated and control cells. For method comparison, ten biological replicates were analyzed in triplicate. Results: Migration of A2780CP ovarian cancer stem-like cells were significantly alleviated by long term glucose restriction but no significant changes were observed in short term study. Beta-hydroxybutyrate enrichment did not produce significant impacts on glucose restriction in short or long term studies. Conclusion: The results of colony formation in soft agar and wound or scratch healing assay were in good correlation and convergence which could be used interchangeably in the investigation of metabolic reprogramming in cancer cells. [GMJ.2020;9:e1831]
Impact of green technology on content of bioactive components in eggplant
Authors: Martirosyan Gayane , Sarikyan Karine , Adjemyan Gohar , Pahlevanyan Armenuhi , Kirakosyan Gohar , Zadayan Merujan , Avagyan Alvina 
Published: December 2023

Background: Green manure fertilizers play a great role in increasing fertility, soil quality and nutrient supply of crops. Additionally, biofertilizers with various strains of fungi increase the availability of biologically active elements for plants. The combined use of green manure and biological fertilizers is of great interest for increasing the content of bioactive components and the functional activity of food.Objective: The main goal of the research was to evaluate the effectiveness of the combined use of various green manure plants and biological fertilizers on the content of bioactive components (total sugars, dry matter, ascorbic acid, B vitamins and macro and micronutrients) in eggplants in the context of increasing food functionality. Methods: Plants from the Fabaceae L. family (beans, peas, and soybeans) were used as green manure. The experiment was set up by a block-randomized method in 4 replications. Biofertilizers were applied at the beginning of intensive growth and at the beginning of the fruiting stage. Soil analysis and content of macro- and micronutrients (Potassium, Calcium, Magnesium, Phosphate, and Iron) in eggplant fruits were done with a spectrophotometry system. Results: Green manure crops and their combination with biofertilizers contributed to an increase in content of vitamin C, Vitamin B1, macro-micronutrients (calcium, potassium, phosphorus, magnesium, and Iron) in all treatment options. The higher yield was recorded in variants with the use of Organit N’ and ‘Organit P’.Conclusion: The concurrent application of green manure and biofertilizers leads to an enhancement of the functional properties of eggplant fruits. This improvement is attributed to the enhanced soil quality and increased levels of nutrients and bioactive compounds, including vitamins C and B1.The positive effect of the applied technology on the eggplant fruits’ qualitative particularities, productivity and functionality creates a basis for recommending the use of tested fertilizers to producers and will serve as a starting point for evaluating the proposed green technology on other crops.Keywords: soya, bean, pea, vitamin C, vitamin B 1
Analysis of studies of stationary tower cranes under wind loads
Authors: Gorbatyuk Ievgenii , Mishchuk Dmitry , Bulavka Oleg , Voliyanuk Volodymer 
Published: December 2023

Loading and unloading operations are an integral part of the technological process of construction. Cranes of various types are mostly used to perform these works.
In modern industrial and civil construction, tower cranes of the stationary type are widely used, which are used in the construction of various types of structures and buildings.
Today, it is impossible to imagine a panorama of a city or a fairly large rural village without the upward, light openwork silhouettes of tower cranes. They are clearly visible against the background of new residential buildings, wherever progressive changes are taking place, where construction is underway. More than 200,000 tower cranes are used on construction sites in the country today.
But when using tower cranes, special attention must be paid to their operation in adverse conditions, because they are mechanisms of increased danger.
One of the important factors in the unfavorable conditions during the full-scale Russian invasion of Ukraine was the shock waves that arise as a result of missile strikes. These shock waves, in turn, cause air pressure and oscillations on the Earth's surface and cause certain seismicity.
To ensure trouble-free operation and increase the reliability of tower cranes, it is important to take into account dynamic loads, which are several times greater than static loads, when calculating structures and components of their working equipment.
Ensuring the stability of stationary tower cranes, especially in the conditions of martial law, is one of the important theoretical and practical tasks. The most important aspect of solving this problem is ensuring stability under the conditions of air shock waves, which cause the effect of dynamic loads on the metal structures of the crane.
Simulation modeling of the strategic development of the higher education system of the Russian Federation
Authors: Kuznetsova Yu. A. 
Published: December 2023

Global trends and current problems of the Russian higher education system determine the relevance of the tasks of analyzing and forecasting the long-term development of the Russian higher education system and developing management decisions aimed at its improvement. These tasks can be solved with the help of computer models of the education system, which allow us to study the behavior of a complex system in dynamics, considering the interactions of its elements, lag effects, and feedback loops. Despite the ongoing research in this area, the issue of management decision support tools for the strategic development of the Russian higher education system has not been resolved.The article discusses the issues of simulation modeling of the higher education system of the Russian Federation, considering its interaction with macroeconomic and demographic factors. The proposed set of simulation models of the higher education system is developed using agent-based modeling and system dynamics methods. The functioning of the education system is described at different levels in the proposed set of models: the individual level, the educational institutions level, and the macroeconomic level. The set of models can be used as the basis for tools to support strategic planning of the Russian Federation’s education system development.
Developing typical profiles of generation Z students to improve the quality of the educational process
Authors: Lerner I. M. , Baykov F. Yu. , Karelina E. A. , Grigoriev S. G. , Sychev A. S. , Dymkova S. S. 
Published: December 2023

Global digital platforms that influence the development of local digital platforms (from national-level platforms to the platform of a particular enterprise), in order to be more effective, must take into account the informational requirements of users, including those determined by their emotional and psychological characteristics. For this purpose, their developers need to know the typical emotional and psychological profiles of users.The construction of typical emotional and psychological profiles of Generation Z learners is necessary for correct and efficient operation of information and educational platforms, in particular, adaptive e-learning environments, which, among other things, implement gamification approaches.To identify the above-mentioned profiles of Generation Z learners, we use R. Cattell’s multifactor testing methodology (form C) and subsequent processing of the obtained results using statistical methods (in the form of cluster analysis). To ensure the representativeness of the results, the study involved 994 students from various universities (the survey results were used in an impersonal form).The analysis of clustering results makes it possible to identify the share of students who are able to independently form new knowledge and obtain original results of intellectual activity, to determine the share of students with a pragmatic attitude to life, as well as those who possess the qualities of business leadership, etc.Based on these results, recommendations for improving the quality of the educational process as a special case of adaptive e-learning environment are formulated.