bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combinatorial Anticancer Effects of The Non-Invasive High Voltage micro-second Pulse Electric Field with Low-Dose Curcumin on A549 Cells
Authors: KUMAR GYANENDRA , Pai Ganesh , Singh Rajshri , Shelar Sandeep B , Patro Birija Sankar , Roy Amitava , Sarathi Ramanujam , Sharma Archana 
Published: October 2023

Abstract

Purpose
Novel, alternative and combinatorial approaches to combat cancers with minimal side effects is the need of the hour, owing to significant therapy-associated adverse effects. Natural molecule curcumin has shown to have significant anticancer action in lung cancers, a major cause of mortality world over. However, usage of curcumin is limited by its poor bioavailability. High voltage microsecond pulse electric field (HV-µsPEF) therapy is an emerging alternative option in cancer therapy which can be used as an effective adjuvant anti-cancer therapy. In the current investigation, we assessed the combinatorial effect of HV-µsPEF with low-dose curcumin on A549 lung cancer cell line with the main objective of minimization of the curcumin dose required for its anti-cancer action.
Method
HV-µsPEF was generated using a previously reported pulse-generator which was combined with low doses of curcumin to assess effects on A549 cell line. Phase-contrast microscopy based cellular morphology analysis, flow-cytometry based analyses to assess the mode of cell death, uptake of curcumin, assessment of reactive oxygen species and that of mitochondrial membrane potential (MMP) loss were carried out.
Results
Our work demonstrates a highly synergistic cell death induction in A549 cells as assessed by phase contrast microscopy and flow-cytometry based analysis due to the increased uptake of curcumin by cancer cells in the presence of HV-µsPEF. This led to increased ROS production and loss of MMP in cancer cells with the combinatorial treatment.
Conclusion
This study shows promising anti-cancer effects in the usage of low doses of curcumin, a natural molecule, with HV-µsPEF. Combined treatment of HV-µsPEF with curcumin in A549 cells increased the uptake of curcumin in the cells leading to effective induction of cell death via increased ROS production and MMP loss effectively minimizing the requirement of high doses of curcumin which are practically not achievable.
Parasitological and molecular characterization of Trypanosoma cruzi of triatomines and mammals from endemic areas for Chagas disease in Venezuela
Authors: Morocoima Antonio , Herrera Leidi , Rattia César , Figueroa Mario , Ferrer Elizabeth 
Published: October 2023

Abstract

It is estimated that 6–7 million people worldwide are infected withTrypanosoma cruzi, the parasite that causes Chagas disease. In Venezuela, Chagas disease remains a public health problem. In this work,T. cruziisolates from six species of triatomines and mammals of the orders Didelphimorphia and Xenarthra, captured in rural communities of Monagas, underwent parasitological and molecular characterization. A total of 471 triatomines and 17 mammals were captured, with a natural infection rate of 41.4% and 70.6%, respectively. In the male NMRI mouse model used for parasitological characterization (Prepatent period, parasitemia curve, mouse mortality and tissular parasitism),T. cruziisolates exhibited high lethality due to their pronounced virulence, irrespective of the parasite load in each mouse, resulting in a mortality rate of 75%. Among the vector isolates, in the mouse model only 2 out of 6 remained alive, while the rest perished during the evaluation. Conversely, the isolates from mammals proved fatal for all the inoculated mice. All isolates were identified as belonging to DTU TcI, based on the molecular markers as intergenic region of the miniexon, D7 divergent domain of the 24Sα rDNA, size-variable domain of the 18S rDNA and hsp60-PCR-RFLP-EcoRV. This study demonstrates the presence of vectors and mammalian reservoirs naturally infected withT. cruziin communities of Monagas, the 9th largest and 9th most populous state in Venezuela. This situation represents a neglected epidemiological problem demanding urgent attention and imperative health care intervention.
Influence of fillets onto mechanical properties of octet-truss lattice structures
Authors: Doutre PIERRE-THOMAS , Grandvallet Christelle , Gobet Léa , Vignat Frederic , Dendievel Rémy 
Published: October 2023

Abstract
The development of Additive Manufacturing (AM) for the fabrication of metallic parts allows structures to be directly manufactured from 3D models. The Electron Beam Melting (EBM) technology is an example of AM technologies that enables the manufacturing of new designs and sophisticated geometries. The process is particularly well suited for the fabrication of lattice structures. Octet-truss lattice structure has been a subject for research during the past 10 years. The potentials that it possesses attract enough interest for manufacturers to use it during the production of parts. Besides being lightweighted, the structure could provide solid mechanical properties. However, researchers always encounter the same issue regarding this particular structure. During Finite Element Analysis (FEA) simulation, stress concentration tends to appear at the struts intersection. This is due to the sharp edges that have very small surface area, thus provoking the presence of singularities. In this respect, the proposed solution is to integrate rounded-joints or fillets at the struts intersection. However, adding fillet entails a mass increase of octet-truss structures. To avoid this mass increase related to these fillets, it is necessary to reduce the size of octet-truss struts. This research work studies the influence of fillets onto the mechanical properties of structures with identical mass. To do so, a set of 15 octet-truss structures are designed with various fillet sizes and strut sizes and compared. Whereas some of them have thick struts and small fillets, others have smaller struts and bigger fillets. The main technical issue in this study remains the design of fillets for octet-truss structures. These latter can indeed be created for up to 12 struts that converge to the same point. Once designed, these octet-truss structures are fabricated by EBM technology and undergo static compression testing. Mechanical properties of each structure are finally determined. Results show that for the same relative density, octet-truss with fillets degrades the mechanical characteristics of the whole structures. This study shows that the strength/mass ratio is better for a structure without fillets. this result can be used in lightweighted applications.
Hypertrophic effects of low-load blood flow restriction training with different repetition schemes: A systematic review and meta-analysis
Authors: de Queiros Victor S. , Rolnick Nicholas , Schoenfeld Brad J. , França Ingrid M. , Vieira João G. , Sardeli Amanda V. , Kamis Okan , Neto Gabriel R. , Cabral Breno G.A.T. , Dantas Paulo M. S. 
Published: October 2023

Abstract

This systematic review and meta-analysis analyzed the effect of low-load resistance training (LL-RT) with blood flow restriction (BFR) versus high-load resistance training (HL-RT) on muscle hypertrophy focusing on the repetition scheme adopted. Four databases were searched to identify randomized controlled trials that compared the effect of LL-RT with BFR versus HL-RT on muscle hypertrophy. Standardized mean differences (SMD) were pooled in a random effects meta-analysis. The overall analysis did not demonstrate significant differences between conditions (SMD = 0.0364; p = 0.196). A similar result was observed when we separately analyzed studies that used sets to momentary muscle failure (SMD = 0.034; p = 0.522), sets of 15 repetitions (SMD = -0.019; p = 747) and a fixed repetition scheme composed of 75 repetitions (SMD = 0.088; p = 0.177). Subgroup analysis on body region indicates no difference in lower limb exercise between HL-RT and LL-RT with BFR (SMD = 0.00065; p = 0.978) while upper limb exercise favors HL-RT (SMD = 0.2313; p = 0.005). In conclusion, LL-RT with BFR elicits muscle hypertrophy similar to HL-RT regardless of the employed repetition scheme, although there appears to be a small beneficial effect in favor of HL-RT in upper limb exercise.
Can strength training or tai ji quan training reduce frailty in postmenopausal women treated with chemotherapy? A secondary data analysis of the GET FIT trial
Authors: Winters-Stone Kerri M. , Stoyles Sydnee , Dieckmann Nathan , Eckstrom Elizabeth , Luoh Shiuh-Wen , Horak Fay , Roeland Eric J. , Li Fuzhong 
Published: October 2023

Abstract

Purpose: To determine whether strength training or tai ji quan can reduce frailty in older, postmenopausal women treated with chemotherapy for cancer.
Methods: We conducted a secondary data analysis from a 3-arm, single-blind, randomized controlled trial where older (50+ years), postmenopausal women cancer survivors were randomized to supervised group exercise programs: tai ji quan, strength training, or stretching control for 6 months. We assessed frailty using a 4-criteria model consisting of weakness, fatigue, inactivity, and slowness. Using logistic regression, we determined whether the frailty phenotype (pre-frailty or frailty) decreased post-intervention, how many and which frailty criteria decreased, and what characteristics identified women most likely to reduce frailty.
Results: Data from 386 women who completed baseline and 6-month testing were used (mean age of 62.0 ± 6.4 years). The odds of improving overall frailty phenotype over 6 months was significantly higher in the strength training group compared to controls (OR [95%CI]: 1.86 [1.09, 3.17]), but not for for tai ji quan (1.44 [0.84, 2.50]). Both strength training (OR 1.99 [1.10, 3.65]) and tai ji quan (OR 2.10 [1.16, 3.84]) led to significantly higher odds of reducing >1 frailty criterion compared to controls. Strength training led to a three-fold reduction in inactivity (p <0.01), and tai ji quan to a two-fold reduction in fatigue (p=0.08) versus control. Higher baseline BMI, comorbidity score, and frailty status characterized women more likely to reduce frailty than other women.
Conclusions: Strength training appears superior to tai ji quan and stretching with respect to reducing overall frailty phenotype among postmenopausal women treated with chemotherapy for cancer, but tai ji quan favorably impacted the number of frailty criteria.
Implications for Cancer Survivors: Supervised, group exercise training that emphasizes strength training and/or tai ji quan may help combat accelerated aging and reduce frailty after cancer treatment.
Facile and low-cost fabrication of Fe3O4@CNTs nanocomposites for effective absorption of electromagnetic waves with high efficiency
Authors: Heydari Farhood , Afghahi Seyad Salman Seyed , Gholizadeh Ahmad , Valmoozi Ali Asghar Ebrahimi 
Published: October 2023

Abstract
In this paper, Fe3O4 nanoparticles (NPs) and nanocomposites of Fe3O4 NPs and functionalized carbon nanotubes (CNTs) under different weight ratios have been made for use in electromagnetic waves (EMW) absorbers in the frequency range of 18-8GHz. Therefore, their structural, magnetic, and dielectric properties were investigated. At first, iron oxide NPs with the chemical formula Fe3O4 were successfully synthesized by the nitrate-citrate method. Then ,CNTs are combined with Fe3O4 NPs under different weight ratios until the desired nanocomposite is formed. After determining the crystal structure of the samples by X-ray diffraction (XRD), Surface morphology and elemental analysis by scanning electron microscope (FESEM) and energy dispersive spectrum attached to it (EDS), Fourier transform infrared spectroscopy (FT-IR), Determining the magnetic properties using a vibrating sample magnetometer (VSM), And checking the dielectric properties of all the samples were done by vector network analyzer (VNA) at room temperature. Fe3O4 NPs /carbon nanotubes (Fe3O4/CNTs) nanocomposites were prepared in six different weight ratios and fully characterized. That among the examples, Sample NC3 under thickness d = 2.25 mm had the best loss in the X frequency band, which came − 27.07 dB. Also, sample NC4 under thickness d = 5.00 mm had the best loss in the Ku frequency band, which came − 38.21 dB.
Distributed Formation Control and Obstacle Avoidance of Nonholonomic Mobile Robots with Unknown Orientation
Authors: Wang Siqi , Wang Heng , Che Weiwei , Li Qing 
Published: October 2023

Abstract
This paper studies the leader-following formation control problem for a group of nonholonomic mobile robots. Different from existing literature, the orientation of each robot is not required to be known, whose accurate value is usually difficult or expensive to obtain via direct measurement. A nonlinear observer is proposed to estimate the orientation of each robot, based on which an obstacle-avoidance constraint using observer-based control barrier function (CBF) is presented, such that the formation problem is converted into a constrained quadratic program (QP), and the desired formation is guaranteed with both static and dynamic obstacles being around. In addition, in order to make the state information of the leader be available to each follower, a new adaptive distributed observer is developed, which eliminates the requirement for leader's acceleration, and avoids the system chattering. Finally, simulation examples and comparisons are provided to validate the effectiveness of the proposed method.
NEDD8-conjugating enzyme E2 UBE2F deficiency promotes lung cancer metastasis by stabilizing Snail
Authors: Lin Xiongzhi , Sun Dongsheng , Yang Shuhan , Cheng Kai , Meng Weijia , Liang Yong , Zhou Lisha , Chen Baofu 
Published: October 2023

Abstract
Lung cancer is the most prevalent malignant tumor, resulting in the highest morbidity and mortality rates worldwide. Approximately 30–40% of lung cancer cases progress to distant metastasis, significantly affecting patient quality of life and survival. However, the mechanisms driving this metastasis remain incompletely understood. Our study aims to investigate the impact of the NEDD8-conjugating enzyme UBE2F on lung cancer metastasis. We established a nude mouse model of lung cancer metastasis with stably silencing the UBE2F protein of human lung cancer cells by tail vein injection. In in vivo animal experiments, we observed a significant increase in the number of metastatic micronodules on the lung surface of nude mice following UBE2F knockout compared to the control group. Moreover, the results of cell scratch and transwell chamber assays indicated that UBE2F knockout enhanced the invasion and migration capabilities of lung cancer cells. Western blot analysis further revealed that UBE2F knockout impeded the degradation of Snail protein, a critical factor in epithelial-mesenchymal transition (EMT), resulting in its accumulation. Together, these findings suggested that the downregulation of UBE2F expression inhibits the degradation of Snail protein, thereby promoting the invasion and metastasis of lung cancer cells.
Improving wood carbon fractions for multiscale forest carbon estimation
Authors: Doraisami Mahendra , Domke Grant M. , Martin Adam R. 
Published: October 2023

Abstract

Background
Wood carbon fractions (CFs)—the proportion of dry woody biomass comprised of elemental carbon (C)—are a key component of forest C estimation. Traditionally, a generic wood CF of 50% has been assumed in forest C estimation analyses and protocols, but in recent decades, studies have specifically quantified differences in wood CFs across several different forest biomes and taxonomic divisions (angiosperms vs gymnosperms), negating the need for generic wood CF assumptions. The Intergovernmental Panel on Climate Change (IPCC), in its 2006 “Guidelines for National Greenhouse Gas Inventories”, published its own multitiered system of protocols for estimating forest C stocks, which included wood CFs that were 1) based on the best available literature (at the time) and 2) a significant improvement over the generic 50% wood CF assumption. However, a considerable number of new studies on wood CFs have been published since 2006, which allow for more accurate, robust, and spatially- and taxonomically- specific wood CFs for use in forest C estimation.
Main text
Despite the availability of large wood CF datasets and evidence that suggests that using data-driven wood CFs may help correct nontrivial errors in forest C stock estimates, the IPCC did not update its recommended wood CFs in its most recent refinement to the 2006 guidelines. In this commentary, we argue that the IPCC’s recommended wood CFs differ substantially from, and are less robust, than wood CFs derived from recently published data-rich studies, and may lead to nontrivial errors in forest C estimates, particularly for countries that rely heavily on Tier 1 methods and recommended wood CFs, i.e., countries of the Global South, many of which are heavily forested. Using our previous studies on this topic, we propose an alternative set of refined wood CFs for use in multiscale forest C estimation studies and protocols. Additionally, we propose a novel decision-making framework for integrating species- and location-specific wood CFs into forest C estimation models.
Conclusion
The refined wood CFs that we present in this commentary may be used by the IPCC to update its recommended wood CFs for use in forest C estimation. Additionally, we propose a novel decision-making framework for integrating data-driven wood CFs into multitiered forest C estimation protocols and studies.
Factors Affecting Fatigue Progression in Multiple Sclerosis Patients
Authors: Machtoub Dima , Fares Callie , Sinan Hassan , Hariri Moustafa Al , Nehme Rim , Chami Joelle , Joukhdar Ronny , Tcheroyan Raya , Adib Salim , Khoury Samia 
Published: October 2023

Abstract

Background Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression.Objectives This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS.Methods This is a retrospective chart review of 483 patients. The primary outcome was a change in the Modified Fatigue Impact Scale (MFIS) score from first to last visit during the study interval, from November 2018 to November 2020.Results The study found that progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications were significantly associated with negative fatigue outcomes. Meanwhile age, sex, smoking frequency, use of pain medications, disease-modifying therapies, BMI, number of relapses, visits, steroid courses, and co-morbidities did not show an association.Conclusion The clinical predictors of worsening fatigue include progressive MS subtypes, worsening depression, worsening pain, use of antidepressants, and use of fatigue medications. Thus, the management of fatigue in patients with MS should include interventions that address the aforementioned variables, optimizing patient care and improving quality of life.
Improved Liquid Phase Exfoliation Technique for the Fabrication of MoS2/Graphene Heterostructure-based Photodetector
Authors: Akeredolu B. J , AHEMEN I. , AMAH A.N , Onojah A.D , KROON R.E , Shakya Jyoti , DANLADI ELI , GAYATHRI HN , GHOSH ARINDAM 
Published: October 2023

Abstract
Two-dimensional materials have gained a lot of research interest and found application in photovoltaics, photodetectors, sensors etc. owing to their exceptional properties such as electrical, optical, and mechanical which is dependent on layer thickness and crystallite size. In this present work molybdenum disulfide (MoS2)/graphene photodetectors were achieved by the hybridization of dispersive MoS2 and graphene. This was achieved with an innovative approach that improved the existing liquid phase exfoliation method in preparing highly dispersed heterostructure nanosheets of MoS2 and graphene in an IPA/water solvent. Furthermore, we achieved a vertically stacked MoS2/graphene photodetector and bare MoS2 photodetector in this study. The MoS2/Graphene hybrid nanosheets (MoS2/Gr NSs) were characterized using spectroscopic and microscopic techniques. The results obtained show the nanosheets have an average lateral size of 350-500 nm, with thickness ≤5 nm, and high crystallinity in the 2H semiconducting phase. The photocurrent, photoresponsivity, specific detectivity, and external quantum efficiency of MoS2/graphene heterostructure were 3.55 µA, 39.44 mA/W, 2.02×1010 Jones, and 7.54%, respectively, at 4V bias voltage, and that of MoS2 photodetector are 0.55 µA, 6.11 mA/W, 3.4 ×109 Jones, and 1.16%, respectively at 650 nm illumination wavelength. These results demonstrate that the photo-response performances of the as-prepared MoS2/Graphene NSs were greatly improved (about 7-fold) compared to that of sole MoS2 NSs. The results provide a simple, inexpensive and efficient method through sequential deposition technique for the fabrication of vertical heterojunctions with improved optoelectronic performance of heterostructure.
Validity of Heart Rate Derived Core Temperature Estimation During Simulated Firefighting Tasks
Authors: Agostinelli Philip , Linder Braxton , Frick Katherine , Bordonie Nicholas , Neal Frances , Sefton JoEllen 
Published: October 2023

Abstract
Rectal core temperature monitoring can mitigate heat injury but can be invasive and impractical. EQ02 + LifeMonitor is a less invasive estimation of core temperature. Therefore, the primary purpose of this study was to determine the validity of the EQ02 + LifeMonitor validity compared to rectal thermometer core temperatures. Thirteen participants completed simulated firefighting tasks with and without turn out gear, involving four rounds of a 5-minute walk on a treadmill at 2.8 mph/2.5% grade and 20 deadlifts over five minutes in heat [40.6°C; 50% humidity]. During each trial participants wore both an EQ02 + LifeMonitor and DataTherm II rectal thermometer. Devices were statistically equivalent [Δupper p < 0.001, Δlower p < 0.001] yet there was a statistically significant difference in the value (~ 0.1°C; p < 0.001).There was a significant effect of devices [p < 0.001] and time [p < 0.001], but no interaction effect [p = 0.70] on core temperature drift. Estimated core temperature was marginally different from the DataTherm II and on average overestimated core temperature. These results suggest the EQ02 + LifeMonitor may be a viable, less invasive alternative of assessing core temperature compared to rectal temperature monitoring, especially during rigorous, intermittent activities.
Balancing Energy consumption and User experience for Multimedia Cloud Computing
Authors: David Preetha Evangeline , Palanisamy Anandhakumar 
Published: October 2023

Abstract
Multimedia services are usually expected to be delivered to the user at the level of Quality of Experience (QoE) which he expects. Hence the multimedia services have moved to a cloud-based environment. A typical cloud-based environment consists of a highly distributed range of servers. There is an urgent need to make these servers highly energy efficient. On the other hand, there exists a trade-off between the energy consumption and the Quality of Experience offered. We have contributed to develop a methodology to guarantee the expected level of QoE, with the minimization of the energy consumed by the various Multimedia data centers by formulating an optimization objective and thereby making optimal decisions. The methodology is self-adaptive and works according to the dynamic changes in the multimedia cloud environment. The approach has been implemented practically and carefully analysed.