bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the welfare regime impact the telework gender stress gap?
Authors: Klarsfeld Alain , Carillo Kevin , Cachat‐Rosset Gaëlle , Saba Tania , Marsan Josianne 
Published: January 2024

AbstractAfter decades of slow diffusion, the acceptance of telework has dramatically accelerated during the pandemic crisis, becoming a mainstream work practice. However, little is still known on the impact of telework design on employee stress, particularly when stress is high due to a major health crisis, at a time when it is crucial that organizations help buffer it. Using the welfare regime literature, we study the effects of telework demands/resources factors on stress and the moderating effects of gender in more or less egalitarian welfare regimes, during a pandemic crisis. Analyzing data collected from 4602 respondents in France and Quebec, we find that telework demands (family interference with work, organizational isolation, emotional isolation) impact stress positively in both welfare regimes. We also find that the gender stress gap is higher in a more gender‐inegalitarian welfare regime than in a more gender‐egalitarian welfare regime. Men's and women's stress is not impacted in the same manner in the two contexts studies. Contributions to research and practice are discussed, along with limitations and potential future research avenues.
Marked enhancement of the immunogenicity of plant‐expressed IgG‐Fc fusion proteins by inclusion of cholera toxin non‐toxic B subunit within the single polypeptide
Authors: Kim Mi‐Young , Vergara Emil , Tran Andy , Paul Matthew John , Kwon Tae‐Ho , Ma Julian K.C. , Jang Yong‐Suk , Reljic Rajko 
Published: January 2024

SummaryImmunoglobulin G (IgG)‐based fusion proteins have been widely exploited as a potential vaccine delivery platform but in the absence of exogenous adjuvants, the lack of robust immunity remains an obstacle. Here, we report on a key modification that overcomes that obstacle. Thus, we constructed an IgG‐Fc vaccine platform for dengue, termed D‐PCF, which in addition to a dengue antigen incorporates the cholera toxin non‐toxic B subunit (CTB) as a molecular adjuvant, with all three proteins expressed as a single polypeptide. Following expression in Nicotiana benthamiana plants, the D‐PCF assembled as polymeric structures of similar size to human IgM, a process driven by the pentamerization of CTB. A marked improvement of functional properties in vitro and immunogenicity in vivo over a previous iteration of the Fc‐fusion protein without CTB [1] was demonstrated. These include enhanced antigen presenting cell binding, internalization and activation, complement activation, epithelial cell interactions and ganglioside binding, as well as more efficient polymerization within the expression host. Following immunization of mice with D‐PCF by a combination of systemic and mucosal (intranasal) routes, we observed robust systemic and mucosal immune responses, as well as systemic T cell responses, significantly higher than those induced by a related Fc‐fusion protein but without CTB. The induced antibodies could bind to the domain III of the dengue virus envelope protein from all four dengue serotypes. Finally, we also demonstrated feasibility of aerosolization of D‐PCF as a prerequisite for vaccine delivery by the respiratory route.
Quality and redox state of bovine sperm cryopreserved with resveratrol use of resveratrol in bovine semen
Authors: Correa Felipe , Ceballos Esteban , Rojano Benjamín , Restrepo Giovanni , Usuga Alexandra 
Published: January 2024

AbstractThe use of antioxidants for semen preservation prevents oxidative damage caused by reactive oxygen species (ROS). One of the most promising natural antioxidants is resveratrol, a phytoalexin derived from plants, grapes, berries, peanuts and red wine. To evaluate the effect of resveratrol on the quality and redox status of cryopreserved bovine semen. Five bulls were subjected to electroejaculation to obtain 15 ejaculates. Each ejaculate was extended with a tris‐egg yolk‐glycerol‐based medium and divided into six aliquots supplemented with 0 (control), 10, 20, 30, 40 and 50 μM of resveratrol. Semen was frozen with liquid nitrogen vapours. Post‐thawing, motility and kinetics were evaluated using a computer‐assisted sperm analysis (CASA) system, membrane integrity using the hypoosmotic test (HOST), morphology by staining with eosin–nigrosin, sperm vitality by fluorescence microscopy with the SYBR14/IP probes. Total antioxidant capacity (TAC) was evaluated using the ABTS•+ assay and ROS was evaluated using spectrofluorimetry with the H2DCFDA probe. For the statistical analysis linear models were adjusted and means were compared using the Tukey test. All concentrations of resveratrol reduced post‐thawed motility and kinetics of sperm. Supplementation with 40 and 50 μM of resveratrol reduced sperm kinetics, and between 30 and 50 μM of resveratrol alterations in the sperm membrane and morphology were observed. However, using resveratrol at 50 μM increased TAC and at 20 μM, it reduced ROS production of cryopreserved bovine semen. Resveratrol appears to have a dose‐dependent effect in which higher doses produce greater sperm alterations, however, it can increase semen TAC during freezing. It is concluded that resveratrol can increase antioxidant capacity and reduce ROS production in cryopreserved bovine semen. However, its use between 10 and 50 μM reduces post‐thawing semen quality.
Exploring the link between the increase in high‐rise buildings and youth jumping suicide in Taiwan: A longitudinal study
Authors: Chen Ying‐Yeh , Yeung Cheuk Yui , Yip Paul S. F. 
Published: January 2024

AbstractIntroductionFrom 2010 to 2021, suicide rates in 15–24 age group in Taiwan increased by 70%, with jumping being the most common method in 2021. We examined the link between the rise in youth suicides and the increase in high‐rise buildings during this period.MethodsSpearman's correlation coefficients and negative binomial mixed‐effects models were employed to assess the association between the increase in high‐rise buildings and jumping suicides over time.ResultsSpearman's correlation coefficients of high‐rise buildings and jumping suicide rates in youth decreased from 0.692 (p < 0.001) in 2010 to 0.354 (p = 0.11) in 2021. Negative binomial mixed‐effects models showed that although jumping suicide rates in youths increased over time, the increase in numbers of high‐rise buildings was not related to rates of youth suicide by jumping. Conversely, in older age groups, the correlations were still prominent.ConclusionDespite the rising trend in youth suicides by jumping over the past 11 years, our study refutes the intuitive notion that the increase in high‐rise buildings contributes to this trend. It is imperative to identify and address other potential factors, such as academic stress and/or family disruptions, for effective prevention of youth suicide.
Evaluation and comparison of the efficacy and safety of cross‐linked and non‐cross‐linked hyaluronic acid in combination with botulinum toxin type A in the treatment of atrophic acne scars: A double‐blind randomized clinical trial
Authors: Behrangi Elham , Dehghani Abbas , Sheikhzadeh Farzad , Goodarzi Azadeh , Roohaninasab Masoomeh 
Published: January 2024

AbstractIntroductionAcne vulgaris is a common skin condition that affects a significant percentage of adolescents, with scarring being one of its permanent complications. This study aims to compare the efficacy and safety of using botulinum toxin type A (BTA) in combination with cross‐linked and non‐cross‐linked hyaluronic acid (HA) for the treatment of atrophic acne scars.MethodOur study is a randomized, double‐blind clinical trial conducted on 16 patients with atrophic acne scars. The patients were randomly assigned to one of two groups: one group received a single session of BTA and crossed link HA combination, while the other group received two sessions of BTA and non‐crossed link HA, 1 month apart. The patients were followed up at 3 and 6 months after baseline to evaluate the number and area of fine and large pores and spots, scar grading, patient satisfaction, and complications.ResultsThe mean age of individuals in both the cross‐linked HA and non‐cross‐linked HA groups was 32.75 ± 4.26 and 31.50 ± 8.48 years, respectively (p= 0.71). In terms of gender, three (37.5%) and seven (87.5%) individuals in the cross‐linked and non‐cross‐linked HA groups were female, respectively (p= 0.11). There were no significant differences in the count and area of fine and large pores and spots between the two groups at baseline and the first follow‐up session. However, in the second follow‐up session, the non‐cross‐linked HA group had significantly better results than the cross‐linked HA group in terms of large pores count and area (p= 0.01). In terms of changes over time, the non‐cross‐linked HA group showed significantly better improvements in the count and area of large pores compared to the cross‐linked HA group (p= 0.03). Additionally, both groups experienced a significant decrease in the count and area of fine pores over time (p= 0.001), but the amount of changes was not statistically significant between the two groups (p= 0.06). Concerning acne grade, initially, 62.5% and 12.5% of cases in the cross‐linked HA and non‐cross‐linked HA groups, respectively, had severe grades. However, in the last session, these percentages significantly decreased to 0% for both groups (p= 0.002 and 0.005, respectively). In terms of treatment complications, none of the patients experienced any adverse effects.ConclusionThe study demonstrated that both cross‐linked HA and non‐cross‐linked HA were effective in reducing acne severity and improving the appearance of pores and spots. The treatments had similar effects on fine pores, spots, and overall acne severity. However, non‐cross‐linked HA appeared to have a better result on large pores compared to cross‐linked HA.
An innovative microcoring technology: A novel approach to acne scar treatment
Authors: Ahn Hyo‐Sang , Kim Soo‐Kyung , Pamela Ruri , Lu Pei‐Hsuan , Vachatimanont Vanravi , Putri Ardhiah Iswanda , Tanojo Henry , Yi Kyu‐Ho 
Published: January 2024

AbstractBackgroundAcne scars present a complex challenge in dermatology and cosmetics, despite advancements in technological interventions such as fractional lasers, microneedling, and surgical procedures. Effective treatment remains elusive for many individuals.
ObjectiveThis study aims to evaluate the efficacy of rotational fractional resection using 1 mm diameter rotating scalpels as a primary treatment for icepick and boxcar scars on the cheeks and glabella region.MethodsThree patients with acne scars underwent a single treatment session of rotational fractional resection. Evaluation occurred at the 2‐month post‐treatment mark to assess improvements in scar appearance and potential skin‐related side effects.ResultsFollowing the treatment, significant improvements were observed in the targeted acne scars. Notable enhancements were noted without major skin‐related adverse effects, except for minor suture marks.ConclusionThe outcomes of this study underscore the potential of rotational fractional resection as an innovative and effective approach in treating acne scars. This single‐session cosmetic procedure shows promise in yielding lasting and quantifiable results, offering a hopeful solution for individuals seeking comprehensive acne scar treatment.
Use of biologics in patients with psoriasis – A retrospective analysis based on real‐world data
Authors: Pan Jing , Chang Xiaodan , Wang Lingyan , Miao Gang , Jin Qiuzi , Guo Ningning , Zhang Jiayu , Lv Yanwei , Wang Lifang 
Published: January 2024

AbstractObjectiveTo summarize and analysis the application of biologic agents in patients with psoriasis in the real world.MethodsRelying on collected data from June 2020 to September 2021 in the database of China Psoriasis Standardized Diagnosis and Treatment Center, 2529 cases of psoriasis patients treated with biologic agents in 188 different tertiary hospitals across China were retrospective analyzed. The collected information mainly includes demographic data (age, gender, psoriasis history), curative effectiveness of used biologics drug withdrawal and its reason. According to the collected information, condition of the usage for each category of biologics and influencing factor of biologics replacement were analyzed.ResultA total of 2529 patients were analyzed, which included 1626 male (64.29%) and 903 female (35.71%) with an average age of 42.12 ± 14.70 (17 ∼ 85) years old; 2336 (92.37%) patients were aged from 19 to 60 years old. Within these patients, 2362 of them (93.40%) had a psoriasis area and severity index (PASI) score, and 1776 of these patients had moderate to severe cases (75.19%). According to the patient's self‐evaluation of the past efficacy of biological agents, secukinumab was chosen by the most people to have the highest efficacy (1140 cases, 93.60%). The main reason for the withdrawal of secukinumab is that the disease is already well controlled at the time of withdrawal (67 cases, 38.95%); for TNF‐ α inhibitor is the poor curative effect; for ustekinumab and ixekizumab were the non‐affordable price.ConclusionsIn the current biotherapy of psoriasis in China, the efficacy of secukinumab is thought by most people to be the highest. Secukinumab is the first choice when the needs of changing biologics appear.
Experience informed procedural skills training
Authors: Loeb Daniel , Lautz Andrew , Fleck Jacob , Zackoff Matthew 
Published: January 2024

AbstractBackgroundPaediatric critical care (PCC) physicians must perform several emergent procedures independently and competently—requiring transition from novice to competent over a 3‐year fellowship. However, skill acquisition is not uniform. Individualised training, adapted to the unique experiences and requirements of each trainee, may enhance competency.ApproachAn individualised, longitudinal critical procedure course was initiated at a large academic paediatric medical centre in July 2022 for PCC fellows (n = 5). The course, informed by procedural performance profiles (P3) generated through real‐time clinical assessments in the paediatric intensive care unit (PICU), was split into three phases: (1) an Initial Simulation Bootcamp—a 2‐day introductory session; (2) Quarterly Structured Booster Sessions (QSBS)—spaced repetition of deliberate practice training individualised to each fellow; and (3) an Annual Refresher Training—a core skills and advanced technique training day.EvaluationFellows began with minimal experience, which formed their initial P3s. Ninety‐two percent (166/180) of bedside procedures received real‐time feedback, enabling longitudinal P3 modification, which identified focus areas for the QSBS. The sessions were well attended and received. Eighty‐nine percent (QSBS #1 5/5, QSBS #2 3/4) of respondents reflected positively on the course's impact on procedural understanding. The course was perceived as more effective than traditional modalities, except bedside training.ImplicationImplementation of a spaced repetition, deliberate practice course informed by longitudinally tracked real‐life performance data is feasible for educators and preferred by trainees. This educational construct can be applied to other clinical skills, bringing precision medicine approach to training.
Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat
Authors: Li Meng , Zhao Yuwei , Chen Xue , Du Xinman , Luo Yue , Li Ying , Kang Jianxun , Wan Like , Tang Jingyun , Fu Xuemei 
Published: January 2024

AbstractBackgroundPlatelet concentrates (PCs) could be prepared using either whole‐blood processes or apheresis instruments. During collection, processing and storage, some biochemical and functional changes occur, which may result in quality reduction. Quality evaluation of PCs may be helpful for the precise control of platelet (PLT) inventory to reduce the risk of refractoriness and adverse effects caused by platelet transfusion.Study Design and MethodsThe study was aimed to evaluate the quality of PCs which were produced by five processes: apheresis (AP) procedures (using three different cell separators: Amicus, Trima Accel and MCS+ instruments), platelet rich plasma (PRP), and buffy coat (BC). A total of 100 PCs (20 of each group) were assessed in respect of routine quality control, morphology, size distribution, destroyed and activated platelets, and production of platelet‐derived microparticles (PMPs).ResultsAll PCs have satisfied the recommended quality of volume, platelet count, residual WBC count, residual RBC count, pH, and sterility according to the Chinese Technical Manual. There was no difference among the 5 groups in morphology and size of PLT and PMPs. Dynamic light scattering test showed that apheresis PCs showed peaks around 10–20 nm, but not whole blood‐derived PCs. PCs prepared by Amicus had the relatively high percentage of destroyed platelet, activated platelets and PMPs than other groups.DiscussionThe data suggested high heterogeneity of PMPs, destroyed and activated platelets in PCs produced by different processes, which might be helpful to manage the platelet inventory for targeted use.
Developing a Performance-Based Approach to the Effect of Roof Features on Fire Safety in Buildings with Atriums
Authors: Yildiz Mehmet Akif , Beyhan Figen 
Published: January 2024

Developing technology, changing social structures, and the threat of resource depletion have changed the design of buildings. Therefore, design approaches are developed to increase user comfort and reduce energy consumption by utilizing natural ventilation and lighting. The design of the distribution of outdoor air and light into the spaces through vertical and horizontal gaps reduces the energy demand of the mechanical systems and increases occupant comfort. The atrium is the preferred vertical gap in modern buildings for distributing natural air and light to interior spaces under appropriate conditions. However, in buildings with atrium, there is a risk of fire spreading in the event of a fire due to the uninterrupted gaps between the rooms. It is necessary to ensure the operability of the design by monitoring the measures to be taken in the early stages of design using performance-based fire safety methods. This study develops design strategies for fire analysis in atrium buildings using computational fluid dynamics (CFD) simulation technology. Atrium height, roof type, and slope characteristics are analyzed for the stack effect, which is the main factor in the movement of smoke and flames. As a result of the numerical analyses consisting of flat, unidirectional, and bidirectional sloping roof type, 10, 20, 30-degree roof slope, and one-meter rising atrium roof variables, the effect degrees for smoke dispersal and temperature control are investigated. Fire Dynamic Simulator, which uses CFD capabilities, and Smokeview software, which can visualize the results, were used for the numerical analysis. Correlation analysis was used to determine the effect of variables on temperature. The results showed that flat roofs and designs with increasing height were effective in delaying the spread of smoke and increasing the stack effect in the atrium, while the contribution of roof slope to fire safety was weak.
Social Media Identity Manipulation: A Review in the Context of Industry 4.0 and Society 5.0
Authors: Gideon Eric , Mohd Jerome Rinjes Ahmad Rifqi , Mohamand Noor Nurul Fathia , Masrom Maslin 
Published: January 2024

Industry 4.0 shaped Society 5.0 which focused heavily on people and gave equal merit to economic development and the resolution of public issues through the utilization of a system that immensely incorporates both cyber and reality. Cyberspace such as media social is heavily used and allows users to become completely anonymous which ultimately gave birth to a new type of crime such as identity manipulation. The advancement of technology has made it simpler for an average person to change the mannerisms, appearance, and physical makeup of another human being, which is often done without their knowledge. When it comes to identity manipulation done by an individual or law enforcement even for a good reason, arguments may ensue. Is it wrong for an individual or law enforcement to pull off identity manipulation in order to lure internet predators or to deter crime by arresting the perpetrator before the crime happened? Isn't this act can be viewed as the act of deceiving somebody into violating the law? These examples of formal arguments about the appropriate course of action that needs to be taken when confronted with a moral issue are known as ethical theories. The aim of this paper is to discuss the three different Ethical Theories including Kantianism, Utilitarianism, and Devine Command Theory on social media identity manipulation in the context of Industry 4.0 and Society 5.0 using secondary data and information acquired from the literature review. Finally, we can reach the conclusion that what is ethically right in societies should be respected and that people should never be used for another's self-gain.
A Dimensionless Large Displacement Model for Flexure Hinges of Elliptical Geometry
Authors: Moschini Simir , Palpacelli Matteo Claudio 
Published: January 2024

Abstract
Flexure hinges are joints typically used in the design and manufacturing of compliant mechanisms, especially when small dimensions do not allow for conventional mechanical devices. In this paper, a closed-form solution is proposed for a nonlinear stiffness model used to describe the static displacements obtained on a flexure hinge of elementary geometry as a function of applied loads. A comparison with the most widely used linear model demonstrates the effectiveness of the proposed nonlinear approach, highlighting the advantages of its use in its scope of application. The obtained results are verified by finite element (FE) simulations, taken as a reference of the actual behavior assumed for the joints studied.
Thermal Test Apparatus for Mini Heat Sinks
Authors: Robins Zaria B. , Asbury Nicholas , Nuszkowski John , Stagon Stephen , Padilla Rafael , Hawes Karl 
Published: January 2024

Abstract
Demands for more powerful and smaller electronic devices have increased the energy dissipation requirements. Accurate determination of the thermal performance of small-sized heat sinks is necessary for innovation within the heat dissipation sector. This study designed, developed, and tested an apparatus for determining the thermal performance of mini heat sinks (MHS). The test apparatus consisted of a wind tunnel, fan, heater, heater block, five temperature sensors, air velocity sensor, and a data acquisition system. A robust dataset was created by testing the heater without an MHS and testing two different MHS materials of polycarbonate (PC) and aluminum (AL) and having 16–21 repeat tests. Linear and polynomial approximations for the temperature profile were explored. For the steady-state tests, the mean and 90% confidence interval were calculated to determine statistically significant differences. The temperature gradient at the interface, rate of heat transfer, and the thermal resistances from the polynomial fit had higher variation than the linear fit. The experimentally determined heater surface temperature had a 90% confidence interval of ±0.3 to ±0.7 °C. The 90% confidence intervals for the thermal resistances were 1.0 to 1.5 K/W for linear and 2.3 to 6.0 K/W for polynomials. Statistically significant differences in the temperature gradient at the interface, rate of heat transfer, and thermal resistances between the bare, PC, and AL were found. Due to heat losses, the linear fit had greater precision, but the polynomial fit had greater accuracy.