bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sinonasal symptoms in migraine without aura: results from the cross-sectional ‘Migraine in Poland’ study
Authors: Straburzynski Marcin , Nowaczewska Magdalena , Czapinska-Ciepiela Ewa K. , Gryglas-Dworak Anna , Budrewicz Slawomir , Waliszewska-Prosół Marta 
Published: November 2023

BackgroundMigraine without aura (MwoA) is often mistaken for rhinosinusitis. The purpose of this study was to assess the prevalence of sinonasal symptoms, sinusitis-targeting medication use and burden of migraine in a large group of people with MwoA attacks accompanied by rhinologic symptoms.MethodsData was collected in a cross-sectional online survey based on an adapted population-based study questionnaire. The analysis included the prevalence of rhinorrhea, mucopurulent nasal discharge, nasal congestion, facial pressure and tenderness to palpation, hyposmia/anosmia and osmophobia.Results1,679 (52.73%) MwoA people were identified among 3,225 respondents (women n = 2,809, 87.10%) aged 13–80 years (median age 39; standard deviation 10.4). 1004/1679 (59.8%) migraine patients reported one or more rhinologic symptoms and 341/1679 (20.3%) MwoA respondents had symptoms that met rhinosinusitis clinical diagnostic criteria during their headache attacks. In migraine patients, osmophobia was associated with hyposmia [n = 141 (12.7%) vs. n = 41 (7.2%); p = 0.001] and a sensation of unpleasant smells [n = 216 (19.4%) vs. n = 45 (8.5%); p = 0.001], while facial tenderness to palpation was associated with facial allodynia [n = 532 (50.4%) vs. n = 211 (33.9%); p &lt; 0.001]. People with migraine accompanied by rhinosinusitis-like symptoms experienced more disease burden and used ‘sinus medications’ more often.ConclusionMwoA patients with rhinosinusitis-like symptoms during migraine attacks require cautious assessment, especially that some symptoms seem to have little value in distinguishing between these disorders (i.e., facial tenderness, hyposmia), while many of these patients have a greater disease burden and therefore often choose medications targeting rhinologic instead of neurologic mechanisms.
Ultrasonographic measurements of the inferior vena cava diameter in newborns: is it a useful tool for choosing an umbilical venous catheter?
Authors: Galdo Francesca , Trappan Antonella , Cossovel Francesca , Rodriguez-Perez Carmen , Ronfani Luca , Montaldo Paolo , Bibalo Cristina , Travan Laura , Risso Francesco Maria 
Published: November 2023

ObjectivesThe primary outcomes of this study were to evaluate the diameters of the inferior vena cava (IVC) in a cohort of newborns and the correlation between newborn weight and IVC diameter. The secondary outcome was to evaluate the concordance between the measurements performed by the two investigators.MethodsTwo blind examiners performed an ultrasonographic (US) evaluation of the IVC diameter in neonates with a weight ranging from 2 to 4 kg. The exclusion criteria included hemodynamic instability, known vascular malformations, and major congenital malformations.ResultsA total of 143 neonates were enrolled between June 2019 and January 2021. All the US examinations were performed in the first 3 days of life. After dividing the patients into two groups according to their weight at the time of examination (2.0–2.99 kg and 3.0–4.0 kg), the median IVC diameters measured by examiner 1 were 3.1 mm (interquartile range 2.8–3.4) and 3.4 mm (interquartile range 2.9–3.8) (p = 0.003) for the two groups, respectively. The median IVC diameters measured by examiner 2 were 3.1 mm (interquartile range 2.6–3.3) and 3.3 mm (interquartile range 2.8–3.8) (p = 0.004) for the two groups, respectively. The intraclass correlation coefficient was 0.93 (95% CI: 0.90–0.95).ConclusionThe IVC diameter values varied widely from 1.2 to 5.2 mm in newborns weighing 2–4 kg, and a low correlation between newborn weight and IVC diameter was found, so measuring IVC diameter may be a recommended step prior to inserting a umbilical venous catheter (UVC). The concordance between operators was good. We contemplated that the IVC diameter could be a potentially useful tool to identify the most appropriate UVC, thus reducing the risk of catheter-related thrombosis.
A novel homozygous splice donor variant in the LRPPRC gene causing Leigh syndrome with epilepsy, a French-Canadian disorder in a Saudi family: case report
Authors: Muthaffar Osama Y. , Abdulkareem Angham Abdulrhman , Ashi Abrar , Naseer Muhammad Imran 
Published: November 2023

BackgroundThe mitochondria are a cellular power house. Tissues are involved in frequent energy consumption, and any failure or irregularity in the continuous energy production could lead to abnormalities. The leucine-rich pentatricopeptide repeat (LRPPRC) gene is one of the mitochondrial-related functions genes; variations in these genes are responsible for complex phenotypes that affect many organs such as the brain, liver, and muscles.Materials and methodsThis study enrolled a family with Leigh syndrome-like phenotype. The molecular diagnosis was conducted by first performing whole exome sequencing (WES), followed by Sanger sequencing.ResultsA novel splice-site variant (c.469 + 2T &gt; A) at the exon–intron boundary in the LRPPRC gene was identified using the WES data analysis. Sanger validation confirmed the autosomal recessive inheritance of the identified variant. Based on the ACMG criteria for variant classification, PVS1 and PM2 suggest that the identified variant in the LRPPRC gene is likely to be pathogenic.ConclusionTo the best of our knowledge, there have been no previous reports of this variant in the LRPPRC gene. Our research not only identifies a novel variant in the LRPPRC gene, but also confirms the unresolved molecular diagnosis of the family. WES can be used as a first-line diagnostic tool in familial cases, particularly in those cases when detailed clinical phenotyping is not possible. Once the molecular diagnosis is confirmed in a family, it is necessary to conduct a thorough re-evaluation of the patients’ specific clinical phenotypes in order to establish a clear genotype–phenotype correlation.
Discovery of the first unconventional myosin: Acanthamoeba myosin-I
Authors: Pollard Thomas D. , Korn Edward D. 
Published: November 2023

Having characterized actin from Acanthamoeba castellanii (Weihing and Korn, Biochemistry, 1971, 10, 590–600) and knowing that myosin had been isolated from the slime mold Physarum (Hatano and Tazawa, Biochim. Biophys. Acta, 1968, 154, 507–519; Adelman and Taylor, Biochemistry, 1969, 8, 4976–4988), we set out in 1969 to find myosin in Acanthamoeba. We used K-EDTA-ATPase activity to assay myosin, because it is a unique feature of muscle myosins. After slightly less than 3 years, we purified a K-EDTA ATPase that interacted with actin. Actin filaments stimulated the Mg-ATPase activity of the crude enzyme, but this was lost with further purification. Recombining fractions from the column where this activity was lost revealed a “cofactor” that allowed actin filaments to stimulate the Mg-ATPase of the purified enzyme. The small size of the heavy chain and physical properties of the purified myosin were unprecedented, so many were skeptical, assuming that our myosin was a proteolytic fragment of a larger myosin similar to muscle or Physarum myosin. Subsequently our laboratories confirmed that Acanthamoeba myosin-I is a novel unconventional myosin that interacts with membrane lipids (Adams and Pollard, Nature, 1989, 340 (6234), 565–568) and that the cofactor is a myosin heavy chain kinase (Maruta and Korn, J. Biol. Chem., 1977, 252, 8329–8332). Phylogenetic analysis (Odronitz and Kollmar, Genome Biology, 2007, 8, R196) later established that class I myosin was the first myosin to appear during the evolution of eukaryotes.
High-capacity boronate affinity-based template-immobilized surface imprinted silica nanoparticles for rapid, selective, and efficient extraction and determination of lincomycin in milk and chicken
Authors: Zhang Yansong , Ding Yihan , Ma Yidan , Zhang Zixin , Wang Yipei , Li Daojin , Wang Shuangshou 
Published: November 2023

BackgroundLincomycin, a natural antibiotic, is widely used by animal and fishery husbandries to prevent infections and treat diseases. It endangers people’s health when they eat foods containing lincomycin residue, especially the frequent consumption of milk and chicken products containing lincomycin. Hence, it is extremely important to evaluate the content of lincomycin in food samples. However, a direct analysis of lincomycin in milk and chicken is quite difficult because of its very low concentration level and the presence of undesirable matrix effects. Therefore, selective and efficient extraction of lincomycin from complex food samples prior to its quantification is required.ResultsIn this study, lincomycin-imprinted silica nanoparticles were prepared according to boronate affinity-based template-immobilized surface imprinting. Silica nanoparticles and boronic acid ligands 3-fluoro-4-formylphenylboronic acid were used as supporting materials and functional monomers, respectively. The prepared lincomycin-imprinted silica nanoparticles exhibited several significant results, such as good specificity, high binding capacity (19.45 mg/g), fast kinetics (6 min), and low binding pH (pH 5.0) toward lincomycin. The reproducibility of lincomycin-imprinted silica nanoparticles was satisfactory. The lincomycin-imprinted silica nanoparticles could still be reused after seven adsorption–desorption cycles, which indicated high chemical stability. In addition, the recoveries of the proposed method for lincomycin at three spiked levels of analysis in milk and chicken were 93.3–103.3% and 90.0–100.0%, respectively.ConclusionThe prepared lincomycin-imprinted silica nanoparticles are feasible for the recognition of target lincomycin with low concentrations in real food samples such as milk and chicken. Our approach makes sample pre-preparation simple, fast, selective, and efficient.
Vaginal Aplasia: Diagnosis, Surgical Correction, Patient Management
Authors: Лемешевская Т.В. , Рубахова Н.Н. , Спиридонова Е.В. 
Published: November 2023

В результате нарушения слияния мюллеровых протоков в процессе эмбриогенеза между собой, с мочеполовым синусом или нерассасывания перегородки при их сращении возникают врожденные пороки развития матки и влагалища. Наиболее тяжелые формы – аплазия влагалища и матки, вызывающие серьезные акушерские и сексуальные нарушения, и вагинальная обструкция, связанная с аплазией влагалища, но при функционирующей матке, что требует неотложной хирургической помощи. В статье представлены методы диагностики и лечения указанной патологии.
As a result of a violation of the fusion of the Mullerian ducts during embryogenesis process with each other, with the urogenital sinus or non-resorption of the septum during their fusion, congenital malformations of the uterus and vagina occur. The most severe forms are the vagina and uterus aplasia causing serious obstetric and sexual dysfunction, and vaginal obstruction associated with the vagina aplasia but with a functioning uterus which requires emergency surgical care. The article presents methods for diagnosing and treating this pathology.
Sosialisasi Bijak Berkomunikasi dengan Internet pada Ibu-Ibu di Kecamatan Mapanget Kota Manado
Authors: Warouw Desie , Reiner Richard Onsu  
Published: November 2023

Di era 4.0 saat ini, ibu-ibu tidak terlepas dari penggunaan internet, baik untuk mengakses informasi, unuk hubungan sosial, juga sebagai sarana hiburan. Namun, banyak ibu-ibu yang menghabiskan waktu berjam-jam menggunakan internet sehingga mengabaikan suami dan anak. Ada juga yang mengalami konflik karena menulis status dan komentar yang menyinggung orang lain di media sosial. Ada juga yang mempercayai berita Hoaks yang beredar di internet.
Melalui sosialisasi tentang Bijak Berkomunikasi Dengan Internet, berkaitan dengan memilih berita yang benar, proteksi informasi pribadi, etika dalam berkomunikasi di internet, hindari penyebaran SARA dan dan pornografi, membaca berita secara keseluruhan, jangan menilai judulnya saja, mengecek kebenaran berita atau informasi baru memberi komentar, hindari provokasi. Melalui sosialisasi juga, meningkatakan pengetahuan tentang bijak berkomunikasi dengan internet, dan meningkatkan ketrampilan tentang penggunaan internet dengan baik dan benar, juga ibu-ibu terhindar dari masalah dalam bermedia sosial atau berinternet.
Kata Kunci : Bijak Berkomunikasi, Internet, Ibu-Ibu
Arah Regulasi Hunian Berimbang Setelah Diundangkannya Undang-Undang Cipta Kerja
Authors: Kurniawan Kevin Hoo , Saly Jeane Neltje 
Published: November 2023

Pasal 28H Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 memberi amanat bahwa Setiap orang berhak hidup sejahtera lahir dan batin, bertempat tinggal, dan mendapatkan lingkungan hidup yang baik dan sehat serta berhak memperoleh pelayanan Kesehatan. Maka, berdasarkan ketentuan tersebut idealnya seluruh rakyat Indonesia memiliki hunian yang layak. Oleh karena itu, pemerintah berupaya mewujudkan hal tersebut melalui konsep hunian berimbang. Dalam prakteknya, penerapan hunian berimbang masih belum efektif dan memiliki beberpa hambatan. Kebanyakan lahan di perkotaan yang ada saat ini dikuasai oleh para pengembang besar lain dan peruntukannya bukan untuk hunian serta hal itu juga membuat pengembang yang ingin membangun rumah bersubsidi mengalami kesulitan karena harga lahan di perkotaan yang tidak terjangkau. Oleh sebab itu pemerintah kembali melakukan penyesuaian dan penambahan ketentuan berkaitan dengan hunian berimbang melalui Undang-Undang No. 06 Tahun 2023 tentang Penetapan Peraturan Pemerintah Pengganti Undang-Undang Nomor 2 Tahun 2022 tentang Cipta Kerja menjadi Undang-Undang beserta aturan turunannya yang berkaitan dengan hunian berimbang yaitu Peraturan Pemerintah Republik Indonesia Nomor 12 Tahun 2021 tentang Perubahan Atas Peraturan Pemerintah Nomor 14 Tahun 2016 Tentang Penyelenggaraan Perumahan dan Kawasan Permukiman. Dengan adanya penambahan dan perubahan ketentuan yang ada tentunya membawa arah baru berkaitan dengan hunian berimbang yang bertujuan untuk memaksimalkan penerapan hunian berimbang.
ANTHROPOLOGICAL MATERIAL FROM THE EXCAVATION OF THE GLOBULAR AMPHORAE CULTURE BURIAL SITES BILYI POTIK AND OZERIANY IN THE TERNOPIL REGION
Authors: Rudych T. О. , Kоzаk О. D. 
Published: November 2023

The remains of 8 individuals were identified in the Bilyi Potik and Ozeriany burial complexes discovered in 2020—2021. Five of them were identified as males and two as females. Some teeth of an elder child were also discovered. The paleopathological study revealed a set of diseases typical of the Ukrainian Globular Amphorae Culture (GAC). Among them are respiratory infections, middle ear closure, and traces of infections, possibly of zoonotic origin. The skull injuries are likely to be of domestic nature. In one case the traces of a healed trepanation were found. This operation has not been described in the GAC population before although it has been found in the Yamnaya culture and was widespread among the population of the Сatacomb culture of Ukraine.
Given the complexity of population formation and the wide area of the culture, in order to identify anthropological connections of this small group of the Podillia population the morphological research was conducted.
The most preserved male crania were reconstructed and analyzed by a craniological program. The skulls from the two sites appear to be morphologically similar. Nevertheless, this new material allows us to raise questions about the anthropological heterogeneity of the population of the eastern group of the GAC.
Long and medium-long, high craniums characterize males from these sites. The shape of the skull vaults is mesocranial or brachycranial tending toward the mesocranial. There are no dolichocranial skulls forms in these samples. The faces of the males are low in absolute size; according to the upper-facial indexes, they fall into the category of broad-faced or medium-faced with a leaning toward broad-faced forms. The orbits are medium-high and low. Noses are narrow and medium-wide, with no broad forms.
Based on craniological features, all the analyzed males belong to the large Caucasoid race, as well as other individuals from the burials of the GAC of Ukraine.
According to the results of a comparative analysis with other individuals of this culture, the northwestern direction of anthropological relations is most clearly recorded in the studied individuals. Morphologically and statistically, the combined series of the Pomeranian (Pamariu, Rzucewo, Haffkьstenkultur) culture of Lithuania and Prussia are the closest to the males from the Bilyi Potik and Ozeryany burial sites.
To confirm our conclusions, we are awaiting the results of biochemical and genetic studies.
BETWEEN SEDENTISM AND NOMADISM: LIFEWAYS ON THE FOREST-STEPPE FRONTIER OF THE LEFT BANK OF DNIEPER IN SCYTHIAN TIME
Authors: Grechko D. S. 
Published: November 2023

The paper is devoted to the issue of reconstruction of the lifeways and economics of the part of tribes in the forest-steppe region of the Left Bank of Dnieper during the Scythian period. The question of the role of nomads and semi nomads in the ethnic and cultural history of the population is one of the most important, since the correct assessment of the interaction between the forest-steppe agricultural population and the different groups of nomads depends on the reconstruction of ethnic processes in the Left-bank forest-steppe du­ring Scythian time. It can be assumed that the Dnieper Left-bank forest-steppe by its environment and convenient ways attracted both farmers and nomads. This led to the use of several ecological niches, which was reflected in the spread of the settlement structure of farmers in the areas that are most suitable for agriculture (chernozem soils of various types) and rich in resources for life, construction, etc. (access to water, forest areas). The nomadic population that has subjugated farmers has repeatedly penetrated the region several times. Nomads mostly used the steppe areas and floodplains of the region, leaving behind the main type of sites — the mounds, burial rites of which are fundamentally different from the settled agricultural population.
The study proposes the conditional use of the term «nomads» for groups of mobile pastoralists only at the time of their penetration into the region. In the new conditions, their lifeways significantly changed. The term reflects a transition to mobile stockbreeding within a limited territory of movement, permanent winter houses near the settlements and hillforts of the settled population of the region, prevailing transhumance, etc. At the moment, the term «semi nomads» is the most adequate for those groups of mobile pastoralists who remained in the forest-steppe region of the Left Bank of Dnieper during the Scythian time. Judging by the flat necropolis in Barvinkova Gora tract near Bilsk hillfort, a part of the migrants from the south turned to a sedentary way of life in the 4th century BC. In general, it can be assumed that the migration of nomads into the region significantly impacted lifeways of the local sedentary population.
LATE ARCHAIC BURIAL 470 FROM THE NECROPOLIS OF PHANAGORIA
Authors: Nazarova T. A. 
Published: November 2023

As a result of the archaeological excavations of the Bosporus necropolises, anthropological collections have been collected and published over the years, giving an idea of the morphological type of ordinary rural and urban residents in different chronological periods. M. M. Gerasimova studied material from the necropolis of Phanagoria, which dates back to the III century BC — IV century AD. The series consists of 58 adult skulls (32 male, 24 female) and 2 children’s skull. The author concludes that the buried belonged to the Pontic variant of the Mediterranean race. The Hellenistic, Sarmatian and Sindo-Meotic components are distinguished, with the latter being predominant.
The proposed publication is devoted to a find obtained from the necropolis of Phanagoria in 1988. A male skeleton (No. 470) was discovered on the southeastern outskirts of the settlement, among children’s burials, and was located in a ground pit with shoulder pads, rectangular in plan. The inventory consisted of a red clay amphora, a black-glazed kylix, an iron akinak dagger, an iron spearhead, a gray clay bowl, and a black-figure lekyph. The burial dates back to the last third of the VI — the first two decades of the V century BC and belonged, according to the author of the excavations O. A. Zavoykin, to a nobility. The deceased was buried at the age of 30—40. The skull is brachycranic, with a wide, medium-high face, has large longitudinal and transverse diameters and a rather powerful bone structure. The significant flattening of the facial area in the horizontal plane attracts attention. The height of the buried person (calculated according to the formula of M. Trotter and G. Glaser) is 169.6 cm. The set of features of the considered skull is a brachycrania in combination with a fairly wide, medium-high face, flattened in the horizontal plane, characteristic of archaeological sauromatians and early Sarmatians.
The craniological parameters of the considered skull approach the maximum values on the world intergroup scale and are extremely far from the usual set of features characteristic of most ancient series in the territory of the entire Northern Black Sea region. Undoubtedly, the burial is unique, judging by the finds in the grave, which indicates a certain status of a man — a warrior. However, the noted features — brachycrania with weakened horizontal profiling at the upper and middle levels, in combination with the descriptive characteristics of the burial — do not fit into the framework of the known Mediterranean series. This may indicate his origin from a different ethnic environment than the Hellenic one. A similar set of features is characteristic of a number of Sarmatian groups. The material of this well-dated burial complex may be evidence of a rather early penetration of the barbarians into the local Hellenistic circle of the inhabitants of Phanagoria.
Wavelet Transforms of Microlensing Data: Denoising, Extracting Intrinsic Pulsations, and Planetary Signals
Authors: Sajadian Sedighe , Fatheddin Hossein 
Published: November 2023

Abstract
Wavelets are waveform functions that describe transient and unstable variations, such as noise. In this work, we study the advantages of discrete and continuous wavelet transforms (DWTs and CWTs) of microlensing data to denoise them and extract their planetary signals and intrinsic pulsations hidden by noise. We first generate synthetic microlensing data and apply wavelet denoising to them. For these simulated microlensing data with ideally Gaussian noise based on the Optical Gravitational Lensing Experiment (OGLE) photometric accuracy, denoising with DWTs reduces standard deviations of data from real models by 0.044–0.048 mag. The efficiency to regenerate real models and planetary signals with denoised data strongly depends on the observing cadence and decreases from 37% to 0.01% with increasing cadence from 15 min to 6 hr. We then apply denoising on 100 microlensing events discovered by the OGLE group. On average, wavelet denoising for these data improves standard deviations and

χ

n

2

of data with respect to the best-fit models by 0.023 mag and 1.16, respectively. The best-performing wavelets (based on the highest signal-to-noise ratio’s peak (

S

/

N

max

), the highest Pearson’s correlation, or the lowest root mean squared error for denoised data) are from the Symlet and Biorthogonal wavelet families in simulated and OGLE data, respectively. In some denoised data, intrinsic stellar pulsations or small planetary like deviations appear that were covered with noise in raw data. However, through DWT denoising rather flattened and wide planetary signals could be reconstructed rather than sharp signals. CWTs and 3D frequency–power–time maps could inform about the existence of sharp signals.