bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges of integrating patient safety into nursing curricula: An integrative literature review
Authors: Dissanayake D.M. Ashoka Priyadarshani , Dharmasena Kumudini Paba , Warnakulasuriya Sudath Shirley Pathmasiri 
Published: January 2024

Introduction The World Health Organization's Multi-Professional Patient Safety (PS) Curriculum (WHO-MPSC) was introduced in 2011, which made PS content easily available for nursing educators to integrate into their own curricula. With the exception of a few developed countries that have their own PS frameworks, many countries have yet to fully integrate PS concepts in pre-licensure healthcare education. The literature reveals numerous challenges when attempting to integrate new patient safety (PS) concepts. Due to the lack of updated synthesis and appraisal of these challenges, a synthesis of findings from the literature was deemed timely and significant. Hence, a literature review was carried out to comprehensively understand the challenges. Methods An integrative review was conducted by searching electronic databases for the years 2011–2022. The Cumulative Index of Nursing and Allied Health Literature (CINAHL), MEDLINE databases and Google Scholar were searched. The search terms were barriers, challenges, nursing students and PS education. Results Twenty reviews met the inclusion criteria. Through this review, investigators were able to identify 5 major categories of challenges (educators’ characteristics, administration, programme structure, curriculum, theory–practice gap) and 17 individual challenges of PS education implementation. Conclusion The theory-practice gap, curriculum development, and programme structure are areas that should be targeted by curriculum developers in nursing education. Furthermore, it was revealed that there is a need for further research on topics such as resistance to change and individual innovativeness among nurse educators.
Environmental impacts of structural lumber production in Japan
Authors: Nakano Katsuyuki , Koide Masahiro , Yamada Yuta , Ogawa Takuya , Hattori Nobuaki 
Published: January 2024

AbstractLow-rise buildings in Japan are predominantly made of wood. Furthermore, the government promotes the use of wood in mid- and high-rise buildings to tackle climate change. Therefore, the environmental impact of structural lumber should be assessed. In this study, we evaluated greenhouse gas (GHG) emissions and resource consumption associated with structural lumber production using life cycle assessment. Herein, we focused on Japanese Agricultural Standard certified structural lumber (artificially dried lumber and machine-grade structural lumber) made from Japanese roundwood. To ensure representativeness, 15 companies and 15 sawmills covering more than 50% of Japan's structural lumber production were selected and data on their production were collected. The results show that the GHG emissions and resource consumption of Japanese structural lumber are 7.99 × 10 kg-CO2e/m3 and 1.77 × 10–3 kg-Sb eq./m3, respectively. The major sources of GHG emissions are electricity and roundwood production. Roundwood and metal tools significantly affect resource consumption. The recycling of rare metals in tools is essential for reducing resource consumption. A significant amount of heat energy is utilized for drying, and this heat energy is supplied from both biomass and fossil fuels. GHG emissions and resource consumption are 5.3 and 1.6 times higher, respectively, if biomass fuel is replaced by fossil fuel. Policies supporting the introduction of biomass boilers have been highly effective. It is recommended to further promote measures such as replacing fossil fuel-based boilers with biomass boilers and effectively utilizing biomass boilers in multiple regional sawmills. In addition, switching from grid electricity to electricity generated by renewable energy sources is effective for further reducing environmental impacts. The long-term use of structural lumber is valid for combating global warming because it fixes carbon for decades. In this study, the CO2 emissions from biomasaluated in terms of carbon neutrality. Appropriate forest management is a prerequisite for carbon neutrality, and the promotion of sustainable forest management, such as reforestation after logging, is crucial.
Comparative chloroplast genomics of 24 species shed light on the genome evolution and phylogeny of subtribe Coelogyninae (Orchidaceae)
Authors: Li Lin , Wu Qiuping , Zhai Junwen , Wu Kunlin , Fang Lin , Li Mingzhi , Zeng Songjun , Li Shijin 
Published: January 2024

AbstractBackgroundThe orchids of the subtribe Coelogyninae are among the most morphologically diverse and economically important groups within the subfamily Epidendroideae. Previous molecular studies have revealed that Coelogyninae is an unambiguously monophyletic group. However, intergeneric and infrageneric relationships within Coelogyninae are largely unresolved. There has been long controversy over the classification among the genera within the subtribe.ResultsThe complete chloroplast (cp.) genomes of 15 species in the subtribe Coelogyninae were newly sequenced and assembled. Together with nine available cp. genomes in GenBank from representative clades of the subtribe, we compared and elucidated the characteristics of 24 Coelogyninae cp. genomes. The results showed that all cp. genomes shared highly conserved structure and contained 135 genes arranged in the same order, including 89 protein-coding genes, 38 tRNAs, and eight rRNAs. Nevertheless, structural variations in relation to particular genes at the IR/SC boundary regions were identified. The diversification pattern of the cp. genomes showed high consistency with the phylogenetic placement of Coelogyninae. The number of different types of SSRs and long repeats exhibited significant differences in the 24 Coelogyninae cp. genomes, wherein mononucleotide repeats (A/T), and palindromic repeats were the most abundant. Four mutation hotspot regions (ycf1a,ndhF-rp132,psaC-ndhE, andrp132-trnL) were determined, which could serve as effective molecular markers. Selection pressure analysis revealed that three genes (ycf1a,rpoC2andycf2genes) might have experienced apparent positive selection during the evolution. Using the alignments of whole cp. genomes and protein-coding sequences, this study presents a well-resolved phylogenetic framework of Coelogyninae.ConclusionThe inclusion of 55 plastid genome data from a nearly complete generic-level sampling provide a comprehensive view of the phylogenetic relationships among genera and species in subtribe Coelogyninae and illustrate the diverse genetic variation patterns of plastid genomes in this species-rich plant group. The inferred relationships and informally recognized major clades within the subtribe are presented. The genetic markers identified here will facilitate future studies on the genetics and phylogeny of subtribe Coelogyninae.
Safer Patients Empowered to Engage and Communicate about Health (SPEECH) in primary care: a feasibility study and process evaluation of an intervention for older people with multiple long-term conditions (multimorbidity)
Authors: Goulding Rebecca , Birtwell Kelly , Hann Mark , Peters Sarah , van Marwijk Harm , Bower Peter 
Published: January 2024

Abstract
Background
Older people with multiple long-term conditions (multimorbidity) (MLTC-M) experience difficulties accessing and interacting with health and care services. Breakdowns in communication between patients and staff can threaten patient safety. To improve communication and reduce risks to patient safety in primary care, we developed an intervention: Safer Patients Empowered to Engage and Communicate about Health (SPEECH). SPEECH comprises a booklet for patients and an associated guide for staff. The booklet is designed to provide patients with information about staff and services, skills to prepare and explain, and confidence to speak up and ask.

Methods
A single-arm mixed methods feasibility study with embedded process evaluation. General practices in the North West of England were recruited. Participating practices invited patients aged 65+ with MLTC-M who had an appointment scheduled during the study period. Patients were asked to complete questionnaires at baseline and follow-up (four to eight weeks after being sent the patient booklet), including the Consultation and Relational Empathy measure, Empowerment Scale, Multimorbidity Treatment Burden Questionnaire, and Primary Care Patient Measure of Safety. Staff completed questionnaires at the end of the study period. A sub-sample of patients and staff were interviewed about the study processes and intervention. Patients and the public were involved in all aspects of the study, from generation of the initial idea to interpretation of findings.

Results
Our target of four general practices were recruited within 50 days of the study information being sent out. A fifth practice was recruited later to boost patient recruitment. We received expressions of interest from 55 patients (approx. 12% of those invited). Our target of 40 patient participants completed baseline questionnaires and were sent the SPEECH booklet. Of these, 38 (95%) completed follow-up. Patients found the intervention and study processes acceptable, and staff found the intervention acceptable and feasible to deliver.

Conclusions
Our findings suggest the intervention is acceptable, and it would be feasible to deliver a trial to assess effectiveness. Prior to further evaluation, study processes and the intervention will be updated to incorporate suggestions from participants.

Trial registration
The study was registered on the ISRCTN registry (ISRCTN13196605: https://doi.org/10.1186/ISRCTN13196605).
Contextualizing the revised Patient Perception of Patient-Centeredness (PPPC-R) scale in primary healthcare settings: a validity and reliability evaluation study
Authors: Cai Yiyuan , Guo Pengfei , Tu Jiong , Hu Mengyao , Liu Lingrui , Ryan Bridget L. , Liao Jing , Dev Rubee , Li Yiran , Huang Tianyu , Wang Ruilin , Kuang Li , Huang Ruonan , Li Xinfang , Melipillán Edmundo Roberto , Zhao Shuaixiang , He Wenjun , Wang Xiaohui , Zhang Nan , Xu Dong 
Published: January 2024

Abstract
Background
An English version of the Patient Perception of Patient-Centeredness (PPPC) scale was recently revised, and it is necessary to test this instrument in different primary care populations.

Aim
This study aimed to assess the validity and reliability of a Chinese version of the PPPC scale.

Design
A mixed method was used in this study. The Delphi method was used to collect qualitative and quantitative data to address the content validity of the PPPC scale by calculating the Content Validity Index, Content Validity Ratio, the adjusted Kappa, and the Item Impact Score. Confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) were used to assess the construct validity of the PPPC scale through a cross-sectional survey. The internal consistency was also assessed.

Setting/participants
In the Delphi consultation, seven experts were consulted through a questionnaire sent by email. The cross-sectional survey interviewed 188 outpatients in Guangzhou city and 108 outpatients in Hohhot City from community health service centers or stations face-to-face.

Results
The 21 items in the scale were relevant to their component. The Item-level Content Validity Index for each item was higher than 0.79, and the average Scale-level content validity index was 0.97 in each evaluation round. The initial proposed 4-factor CFA model did not fit adequately. Still, we found a 3-factor solution based on our EFA model and the validation via the CFA model (model fit: $${\chi }^{2}=294.573$$

χ

2

=
294.573

, P < 0.001, RMSEA = 0.044, CFI = 0.981; factor loadings: 0.553 to 0.888). Cronbach's α also indicated good internal consistency reliability: The overall Cronbach's α was 0.922, and the Cronbach's α for each factor was 0.851, 0.872, and 0.717, respectively.

Conclusions
The Chinese version of the PPPC scale provides a valuable tool for evaluating patient-centered medical service quality.
Health care seeking behaviour towards cervical cancer screening among women aged 30–49 years in Arbaminch town, Southern Ethiopia, 2023
Authors: Kussia Begetayinoral , Shewangizaw Misgun , Abebe Samuel , Alemu Habtamu , Simon Tesfahun 
Published: January 2024

Abstract
Background
Cervical cancer is a preventable disease. However, it remains the commonest and deadly cancer in women worldwide. Health care seeking behaviour is not well studied in Ethiopia even though it is crucial in averting cervical cancer by maximizing cervical cancer screening utilization. Therefore, this study amid to assess health care seeking behaviour towards cervical cancer screening and its associated factors among women aged 30–49 years in Arba Minch town, Southern Ethiopia, 2023.

Methods
A community-based cross-sectional study design was conducted on 414 women who are in the age range of 30–49 in Arba Minch town from January 2-February20, 2023. Study participants were selected by a simple random sampling technique from all kebeles and data were collected using pretested interviewer administered questionnaires. SPSS version 27 was used to conduct binary and multivariable logistic regression analysis. Socio-demographic characteristics of the respondents were described using descriptive statistics. Furthermore, binary and multivariable logistic regression analyses were made to find the factors associated with health care seeking behaviour. Variables with a p-value less than 0.25 on binary logistic regression were selected for multivariable logistic regression. Variables with a p-value < 0.05 were considered statistically significant. The reliability and internal consistency of the constructs of health belief model were calculated independently using Cronbach’s alpha.

Result
The prevalence of health care seeking behaviour towards cervical cancer screening was 197(47.6%) [95%CI: 42.7-52.5%]. Respondents’ good knowledge [AOR = 1.55, 95%CI: 1.01–2.39], positive perceived susceptibility [AOR = 3.63, 95%CI: 2.06–6.42], positive perceived severity [AOR = 2.65, 95%CI: 1.71–4.09], positive perceived benefits [AOR = 4.85, 95%CI: 2.92–7.87] were significantly associated with health seeking behaviour.

Conclusion
The prevalence of health care seeking behaviour towards cervical cancer screening is low in this study. To maximize the health care seeking behavior of women, further acting on perceived susceptibility, respondents’ knowledge, perceived severity, and perceived benefit of the woman are crucial.
Study of clinical traits and systemic immune inflammation index assessments in patients with endogenous endophthalmitis over the last ten years
Authors: Niu Rui , Yan Zhongyang , Wang Yanhui , Li Yalin , Feng Wei , Liu Jianan , Wang Lifei 
Published: January 2024

Abstract
Purpose
The clinical aspects and prognosis of eyes with endogenous endophthalmitis were compared over the last ten years. The occurrence and progression of endophthalmitis are linked to the systemic immune inflammation index (SII) and clinical features.

Methods
The study comprised patients with endogenous endophthalmitis and 64 patients without endophthalmitis who were treated at Hebei Province Eye Hospital in the last ten years. According to the prognostic visual acuity, patients with endophthalmitis were split into two groups: Group A and Group B. Underlying disease (hypertension, diabetes, tuberculosis), infection risk (liver abscess, urinary tract infection, and recent abdominal surgery), signs and symptoms, and complete blood count were among the evaluation parameters (neutrophil count, lymphocyte count, monocyte count, platelet count, red blood cell distribution width). The NLR, PLR, MLR, and SII values were calculated. A nonparametric test was used to examine the clinical features and complete blood count results of patients in each group. To determine the parameters linked to endophthalmitis progression, researchers used principal component and ordinal logistic regression analyses.

Results
The study comprised a total of 25 eyes and 22 individuals with endogenous endophthalmitis. Infectious bacteria included Staphylococcus aureus, Micrococcus luteus, Staphylococcus hemolyticus, and so on. The visual acuity of the affected eye ranged from 2.7 (1.55, 2.7) LogMAR to 1.22 (0.6, 2.7) LogMAR during the 6-month to 8-year follow-up period. The neutrophil, monocyte, and PLT counts, NLR, PLR, and SII values and other markers were considerably higher in Groups A and B than in the control group. The likelihood model of the SII and sex, age, onset time, diabetes, hypertension, monocyte count, and red blood cell distribution was the best, and its increase was strongly connected with the occurrence and progression of endophthalmitis, according to ordinal regression analysis.

Conclusion
Patients with endophthalmitis had significantly higher blood neutrophil, monocyte, and PLT counts and SII, NLR, PLR, and MLR values. The SII can be employed as a biomarker for predicting endophthalmitis severity and prognosis.
Testing a model of benefit-finding and growth in youths with chronic health conditions
Authors: von Rezori Roman E. , Baumeister Harald , Holl Reinhard W. , Minden Kirsten , Müller-Stierlin Annabel S. , Reinauer Christina , Temming Svenja , Warschburger Petra 
Published: January 2024

Abstract
Background
The experience of benefit-finding and growth (BFG), defined as perceiving positive life changes resulting from adversity, is increasingly studied among youths with chronic health conditions (CCs). However, empirical evidence is scarce for explaining individual differences in BFG. The study aimed to test a model of BFG, including an interplay of personal and environmental factors and coping processes.

Methods
A sample of N = 498 youths (12–21 years) recruited from three German patient registries for CCs (type 1 diabetes: n = 388, juvenile idiopathic arthritis: n = 82, cystic fibrosis: n = 28) completed a questionnaire including self-reported optimism, social support from parents and peers, coping strategies, and BFG. The model was created to reflect the theoretical assumptions of the Life Crisis and Personal Growth model and current empirical evidence. Structural equation modeling was conducted to evaluate the incremental explanatory power of optimism, peer group integration, parental support, acceptance, cognitive reappraisal, and seeking social support over and above sociodemographic and disease-related characteristics.

Results
The model (CFI = 0.93; RMSEA = 0.04; SRMR = 0.05) explained 32% of the variance in BFG. Controlling for sociodemographic and disease-related characteristics, acceptance, cognitive reappraisal, and seeking social support were directly and positively linked to BFG. All tested coping strategies significantly mediated the association between optimism and BFG, whereas seeking social support significantly mediated the relation between peer group integration and BFG.

Discussion
The study stresses the prominent role of emotion-focused coping strategies and peer group integration in enhancing BFG in youths with CCs.

Trial registration
German Clinical Trials Register (DRKS), no. DRKS00025125. Registered on May 17, 2021.
Effects of the COVID-19 pandemic on the outcomes of HIV-exposed neonates: a Zimbabwean tertiary hospital experience
Authors: Gannon Hannah , Chappell Elizabeth , Ford Deborah , Gibb Diana M , Chimwaza Anesu , Manika Ngoni , Wedderburn Catherine J , Nenguke Zivai Mupambireyi , Cowan Frances M , Gibb Tom , Phillips Andrew , Mushavi Angela , Fitzgerald Felicity , Heys Michelle , Chimhuya Simbarashe , Bwakura-Dangarembizi Mutsa 
Published: January 2024

Abstract
Introduction
The COVID-19 pandemic has globally impacted health service access, delivery and resources. There are limited data regarding the impact on the prevention of mother to child transmission (PMTCT) service delivery in low-resource settings. Neotree (www.neotree.org) combines data collection, clinical decision support and education to improve care for neonates. Here we evaluate impacts of COVID-19 on care for HIV-exposed neonates.

Methods
Data on HIV-exposed neonates admitted to the neonatal unit (NNU) at Sally Mugabe Central Hospital, Zimbabwe, between 01/06/2019 and 31/12/2021 were analysed, with pandemic start defined as 21/03/2020 and periods of industrial action (doctors (September 2019-January 2020) and nurses (June 2020-September 2020)) included, resulting in modelling during six time periods: pre-doctors’ strike (baseline); doctors’ strike; post-doctors’ strike and pre-COVID; COVID and pre-nurses’ strike; nurses’ strike; post nurses’ strike. Interrupted time series models were used to explore changes in indicators over time.

Results
Of 8,333 neonates admitted to the NNU, 904 (11%) were HIV-exposed. Mothers of 706/765 (92%) HIV-exposed neonates reported receipt of antiretroviral therapy (ART) during pregnancy. Compared to the baseline period when average admissions were 78 per week (95% confidence interval (CI) 70–87), significantly fewer neonates were admitted during all subsequent periods until after the nurses’ strike, with the lowest average number during the nurses’ strike (28, 95% CI 23–34, p < 0.001). Across all time periods excluding the nurses strike, average mortality was 20% (95% CI 18–21), but rose to 34% (95% CI 25, 46) during the nurses’ strike. There was no evidence for heterogeneity (p > 0.22) in numbers of admissions or mortality by HIV exposure status. Fewer HIV-exposed neonates received a PCR test during the pandemic (23%) compared to the pre-pandemic periods (40%) (RR 0.59, 95% CI 0.41–0.84, p < 0.001). The proportion of HIV-exposed neonates who received antiretroviral prophylaxis during admission was high throughout, averaging between 84% and 95% in each time-period.

Conclusion
While antiretroviral prophylaxis for HIV-exposed neonates remained high throughout, concerning data on low admissions and increased mortality, similar in HIV-exposed and unexposed neonates, and reduced HIV testing, suggest some aspects of care may have been compromised due to indirect effects of the pandemic.
Evaluation of serum interleukin-17 A and interleukin-22 levels in pediatric patients with autism spectrum disorder: a pilot study
Authors: Sallam Dina E. , Shaker Youstina S. , Mostafa Gehan A. , El-Hossiny Reham M. , Taha Sara I. , Ahamed Mostafa Abd Elazeem Hassan 
Published: January 2024

Abstract
Background
Many neurodevelopmental abnormalities are connected to autism spectrum disorder (ASD), which can result in inflammation and elevated cytokine levels due to immune system dysregulation. Interleukin (IL)-17 A and IL-22 have been linked to the regulation of host defense against pathogens at the barrier surface, the regeneration of injured tissue, and the integration of the neurological, endocrine, and immune systems. Several studies have investigated the possible connection between IL-17 A and ASD as well as the severity of behavioral symptoms, but few of them included IL-22.

Objectives
To measure serum levels of interleukin (IL)-17 A and IL-22 in children with ASD and to investigate their association with disease severity.

Methods
This pilot study was performed on 24 children with ASD and 24 matched controls. Childhood Autism Rating Scale (CARS) assessed ASD severity, and serum levels of IL-17 A and IL-22 were assessed by enzyme-linked immunosorbent assay (ELISA).

Results
In ASD patients, serum levels of IL-17 A and IL-22 showed a significant increase compared to controls (p-values < 0.001). We compared serum levels of IL-17 A and IL-22 according to the severity categories by CARS and could not find any significant differences (p-values > 0.05). Only IL-22 had a significant positive correlation with ASD severity by CARS scores.

Conclusions
Raised serum levels of IL-17 A and IL-22 are associated with ASD; only IL-22, not IL-17 A, is correlated with ASD severity. This finding proposes IL-22 as a possible future effective target for ASD treatment. To fully comprehend the significance of these cytokines in ASD and their possible effects on ASD diagnosis and treatment, more research on a wider scale is required.