bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reaction of O(3
P) Atoms with Benzene
Authors: Berndt Torsten , Böge Olaf 
Published: April 2004

Abstract
The gas-phase reaction of O(3
P) atoms with benzene was investigated in a flow system in the pressure range of 50–100mbar and a temperature of 295 ± 2K with a focus on the product formation. O2 concentrations in the carrier gas were in the range of (7.7–84) × 1014 molecule cm−3. The primary stable products detected were phenol, benzene oxide/oxepin and a not identified compound with the probable composition C5H6O. The yields of phenol and benzene oxide/oxepin were 0.12 ± 0.02 and 0.26 ± 0.06, respectively, being not affected by the experimental conditions. For benzene oxide/oxepin, a rapid consecutive reaction with O(3
P) atoms was observed with a rate coefficient of k
(295K) = (1.1 ± 0.1) × 10−10cm3 molecule−1s−1 measured at a pressure of 100mbar. A substance with the formula C6H6O2 (likely oxepin 4,5-epoxide or oxepin 2,3-epoxide), the isomers of muconaldehyde, as well as formic acid, acrolein and trans-butenedial were identified as products of the reaction of O(3
P) atoms with benzene oxide/oxepin.
Season, decay stage, habitat, temperature and carrion beetles allow estimating the post‐mortem interval of wild boar carcasses
Authors: Müller Jörg , Rietz Janine , von Hoermann Christian , Conraths Franz J. , Benbow M. Eric , Mitesser Oliver , Schlüter Jens , Lackner Tomáš , Reckel Frank , Heurich Marco 
Published: January 2024

Abstract

The decay process of animal carcasses is a highly complex succession driven by abiotic and biotic variables and their interactions. As an underexplored ecological recycling process, understanding carrion decomposition associated with pandemics such as African swine fever is important for predicting the rate and post‐mortem interval (PMI) variation of wild animal carcasses to improve disease management.

To model PMIs of wild boar, we deployed 73 wild boar carcasses in four different forest habitat types throughout a year and monitored the decomposition process, carrion beetles and blow fly larval populations. The 601 single observations were split randomly into 501 training data and 100 validation data.

A linear additive mixed model for log‐transformed PMI values using the training data identified the decay stage, day of year, ambient temperature during sampling, habitat and prevalence of Oiceoptoma thoracicum (Silphidae) as predictive variables for time since death, but neither the initial body mass nor if a fresh or previous frozen carcass was used. Using the validation data, this model showed a high predictive power for log‐transformed PMI values (R2 = 0.80).

This study aimed at improving the methodology of estimating the PMI of wild boar carcasses based on important abiotic and biotic environmental factors that can be easily assessed in the field. Using only a small set of predictors, including a conspicuous beetle species, allowed prediction of the mean, minimum and maximum PMI of wild boar carcasses. The strong effects of a few surrogates on PMI in our model suggest that this model can easily be transferred to wider regions of Central Europe by retraining the model with data from a broader environmental space and can thus be instrumental in assessing timing of disease introduction in areas newly affected by emerging diseases such as African swine fever.
First‐ever acute ischemic strokes in HIV‐infected persons: A case–control study from stroke units
Authors: Stammler Romain , Guillaume Jessica , Mazighi Mikael , Denier Christian , Raynouard Igor , Lapergue Bertrand , De Broucker Thomas , Meseguer Elena , Hosseini Hassan , Leger Anne , Smadja Didier , Lamy Catherine , Obadia Michael , Moulignier Antoine 
Published: January 2024

AbstractObjectiveThe stroke risk for persons living with human immunodeficiency virus (PLHIVs) doubled compared to uninfected individuals. Stroke‐unit (SU)—access, acute reperfusion therapy—use and outcome data on PLHIVs admitted for acute ischemic stroke (AIS) are scarce.MethodsAIS patients admitted (01 January 2017 to 31 January 2021) to 10 representative Paris‐area SUs were screened retrospectively from the National Hospitalization Database. PLHIVs were compared to age‐, initial NIHSS‐ and sex‐matched HIV‐uninfected controls (HUCs). Outcome was the 90‐day modified Rankin Scale score.ResultsAmong 126 PLHIVs with confirmed first‐ever AIS, ~80% were admitted outside the thrombolysis‐administration window. Despite antiretrovirals, uncontrolled plasma HIV loads exceeded 50 copies/mL (26% of all PLHIVs; 38% of those ≤55 years). PLHIVs' stroke causes by decreasing frequency were large artery atherosclerosis (LAA), undetermined, other cause, cerebral small‐vessel disease (CSVD) or cardioembolism. No stroke etiology was associated with HIV duration or detectable HIVemia. MRI revealed previously unknown AIS in one in three PLHIVs, twice the HUC rate (p = 0.006). Neither group had optimally controlled modifiable cardiovascular risk factors (CVRFs): 20%–30% without specific hypertension, diabetes, and/or dyslipidemia treatments. Their stroke outcomes were comparable. Multivariable analyses retained good prognosis associated solely with initial NIHSS or reperfusion therapy. Older age and hypertension were associated with CSVD/LAA for all PLHIVs. Standard neurovascular care and reperfusion therapy were well‐tolerated.InterpretationThe high uncontrolled HIV‐infection rate and suboptimal CVRF treatment support heightened vigilance to counter suboptimal HIV suppression and antiretroviral adherence, and improve CVRF prevention, mainly for younger PLHIVs. Those preventive, routine measures could lower PLHIVs' AIS risk.
Organic Chameleon: Fluorescence, Phosphorescence and Radical Afterglow Triple Emission from Naphthylimide Functionalized Triphenylphosphine Derivatives
Authors: Tang Meng , Wen Jingyi , Sun Yitong , Hou Qinggao , Cai Xueqi , He Wenjie , Xie Xuancai , Ding Huangting , Li Fei , Zheng Liyan , Shi Yonggang , Cao Qiue 
Published: January 2024

AbstractOrganic radical luminescent materials have attracted worldwide attention because of their absolute spin‐allowed radiative transition and sensitivity to the environment, which give it multiple stimulus response properties. Nowadays, how to regulate and utilize the sensitivity of radicals has become a hot and difficult issue. Here, arylphosphonium bromide salts are introduced into the molecular backbone of naphthimide (NMI) using an intramolecular counterion strategy, and prepared a novel multifunctional stabilized radical luminescent: TPP‐o‐3OMe‐NMI‐Br. Interestingly, this molecule exhibits different assembly modes in different solvents, resulting in the generation of two crystals with different fluorescence (green: G‐C; orange–yellow: Y‐C), in which the Y‐C crystalline powder exhibits excellent stabilization properties for doublet and triplet excitons, which induce the emission of orange–yellow radical afterglow, and exhibits multi‐stimuli responsiveness to external pressure (P), temperature (T) and water (W). Moreover, interesting time‐dependent photoactivated colorful fluorescence and orange–yellow radical afterglow can be observed in TPP‐o‐3OMe‐NMI‐Br@PMMA films with different doping ratios and exhibit multi‐color tunability, multiple stimulus responses, multiple data encryption, and optical information erase/write behavior. This study not only broadens the types and applications of organic radical long afterglow materials but also provides new ideas for designing new organic “chameleon” luminescent materials in the field of smart luminescence materials.
Efficient and Stable Multicolor Emissions of the Coumarin‐Modified Cs3LnCl6 Lead‐Free Perovskite Nanocrystals and LED Application
Authors: Sun Liheng , Dong Biao , Sun Jiao , Wang Yiming , Wang Yuqi , Hu Songtao , Zhou Bingshuai , Bai Xue , Xu Lin , Zhou Donglei , Song Hongwei 
Published: January 2024

AbstractLanthanide‐based lead‐free perovskite materials hold great promise for the development of high‐resolution full‐color displays in the future. Here, various Cs3LnCl6 perovskite nanocrystals (NCs) emitting light across the visible to near‐infrared spectrum with remarkably high photoluminescence quantum yield (PLQY) are systemically prepared. Especially, by introducing multifunctional coumarin small molecules into Cs3EuCl6 NCs as an intermediate state, Cs3EuCl6 NCs can achieve an impressive PLQY of 92.4% with pure red emission and an exceptional energy transfer efficiency of nearly 93.2%. Furthermore, the lanthanide‐based electroluminescent devices in red, green, and blue are successfully fabricated. Among them, the Cs3EuCl6‐NC‐based red light‐emitting diode (LED) demonstrates a FWHM of 18 nm at 617 nm, an external quantum efficiency up to 5.17%, and a maximum brightness of 2373 cd m−2, which is the most excellent reported for lead‐free narrowband (within 20 nm) emission devices. Notably, these devices exhibit an operating half‐life of 440 h at a brightness level of 100 cd m−2, surpassing the performance of most reported lead‐free perovskite LEDs (PLEDs). This work opens up exciting possibilities for the future commercialization of lanthanide‐based PLEDs in the display industry, paving the way for more vibrant, energy‐efficient, and long‐lasting display technologies.
Eliminating Non‐Corner‐Sharing Octahedral for Efficient and Stable Perovskite Solar Cells
Authors: Jiang Yang , Du Hong‐Qiang , Zhi Rui , Rothmann Mathias Uller , Wang Yulong , Wang Chao , Liang Guijie , Hu Zhi‐Yi , Cheng Yi‐Bing , Li Wei 
Published: January 2024

AbstractThe metal halide (BX6)4‐ octahedron, where B represents a metal cation and X represents a halide anion, is regarded as the fundamental structural and functional unit of metal halide perovskites. However, the influence of the way the (BX6)4− octahedra connect to each other has on the structural stability and optoelectronic properties of metal halide perovskite is still unclear. Here, the octahedral connectivity, including corner‐, edge‐, and face‐sharing, of various CsxFA1‐xPbI3 (0 ≤ x ≤ 0.3) perovskite films is tuned and reliably characterized through compositional and additive engineering, and with ultralow‐dose transmission electron microscopy. It is found that the overall solar cell device performance, the charge carrier lifetime, the open‐circuit voltage, and the current density–voltage hysteresis are all improved when the films consist of corner‐sharing octahedra, and non‐corner sharing phases are suppressed, even in films with the same chemical composition. Additionally, it is found that the structural, optoelectronic, and device performance stabilities are similarly enhanced when non‐corner‐sharing connectivities are suppressed. This approach, combining macroscopic device tests and microscopic material characterization, provides a powerful tool enabling a thorough understanding of the impact of octahedral connectivity on device performance, and opens a new parameter space for designing high‐performance photovoltaic metal halide perovskite devices.
Highly Stable Organic Molecular Porous Solid Electrolyte with One‐Dimensional Ion Migration Channel for Solid‐State Lithium−Oxygen Battery
Authors: Li Jia‐Xin , Guan De‐Hui , Wang Xiao‐Xue , Miao Cheng‐Lin , Li Jian‐You , Xu Ji‐Jing 
Published: January 2024

AbstractSolid‐state lithium−oxygen (Li−O2) batteries have been widely recognized as one of the candidates for the next‐generation of energy storage batteries. However, the development of solid‐state Li−O2 batteries has been hindered by the lack of solid‐state electrolyte (SSE) with high ionic conductivity at room temperature, high Li+ transference number, and the high stability to air. Herein, the organic molecular porous solid cucurbit[7]uril (CB[7]) with one‐dimensional (1D) ion migration channels is developed as the SSE for solid‐state Li−O2 batteries. Taking advantage of the 1D ion migration channel for Li+ conduction, CB[7] SSE achieves high ionic conductivity (2.45 × 10−4 S cm−1 at 25 °C). Moreover, the noncovalent interactions facilitated the immobilization of anions, realizing a high Li+ transference number (tLi+ = 0.81) and Li+ uniform distribution. The CB[7] SSE also shows a wide electrochemical stability window of 0–4.65 V and high thermal stability and chemical stability, as well as realizes stable Li+ plating/stripping (more than 1000 h at 0.3 mA cm−2). As a result, the CB[7] SSE endows solid‐state Li−O2 batteries with superior rate capability and long‐term discharge/charge stability (up to 500 h). This design strategy of CB[7] SSE paves the way for stable and efficient solid‐state Li−O2 batteries toward practical applications.
Melanoma Derived Exosomes Amplify Radiotherapy Induced Abscopal Effect via IRF7/I‐IFN Axis in Macrophages
Authors: Wang Lu , Shen Kangjie , Gao Zixu , Ren Ming , Wei Chenlu , Yang Yang , Li Yinlam , Zhu Yu , Zhang Simin , Ding Yiteng , Zhang Tianyi , Li Jianrui , Zhu Ming , Zheng Shaoluan , Yang Yanwen , Du Shisuo , Wei Chuanyuan , Gu Jianying 
Published: January 2024

AbstractRadiotherapy (RT) can induce tumor regression outside the irradiation field, known as the abscopal effect. However, the detailed underlying mechanisms remain largely unknown. A tumor‐bearing mouse model is successfully constructed by inducing both subcutaneous tumors and lung metastases. Single‐cell RNA sequencing, immunofluorescence, and flow cytometry are performed to explore the regulation of tumor microenvironment (TME) by RT. A series of in vitro assays, including luciferase reporter, RNA Pulldown, and fluorescent in situ hybridization (FISH) assays, are performed to evaluate the detailed mechanism of the abscopal effect. In addition, in vivo assays are performed to investigate combination therapy strategies for enhancing the abscopal effect. The results showed that RT significantly inhibited localized tumor and lung metastasis progression and improved the TME. Mechanistically, RT promoted the release of tumor‐derived exosomes carrying circPIK3R3, which is taken up by macrophages. circPIK3R3 promoted Type I interferon (I‐IFN) secretion and M1 polarization via the miR‐872‐3p/IRF7 axis. Secreted I‐IFN activated the JAK/STAT signaling pathway in CD8+ T cells, and promoted IFN‐γ and GZMB secretion. Together, the study shows that tumor‐derived exosomes promote I‐IFN secretion via the circPIK3R3/miR‐872‐3p/IRF7 axis in macrophages and enhance the anti‐tumor immune response of CD8+ T cells.
Giant Optical Anisotropy in a Covalent Molybdenum Tellurite via Oxyanion Polymerization
Authors: Wu Tianhui , Jiang Xingxing , Duanmu Kaining , Wu Chao , Lin Zheshuai , Huang Zhipeng , Humphrey Mark G. , Zhang Chi 
Published: January 2024

AbstractLarge birefringence is a crucial but hard‐to‐achieve optical parameter that is a necessity for birefringent crystals in practical applications involving modulation of the polarization of light in modern opto‐electronic areas. Herein, an oxyanion polymerization strategy that involves the combination of two different types of second‐order Jahn–Teller distorted units is employed to realize giant anisotropy in a covalent molybdenum tellurite. Mo(H2O)Te2O7 (MTO) exhibits a record birefringence value for an inorganic UV‐transparent oxide crystalline material of 0.528 @ 546 nm, which is also significantly larger than those of all commercial birefringent crystals. MTO has a UV absorption edge of 366 nm and displays a strong powder second‐harmonic generation response of 5.4 times that of KH2PO4. The dominant roles of the condensed polytellurite oxyanions [Te8O20]8− in combination with the [MoO6]6− polyhedra in achieving the giant birefringence in MTO are clarified by structural analysis and first‐principles calculations. The results suggest that polymerization of polarizability‐anisotropic oxyanions may unlock the promise of birefringent crystals with exceptional birefringence.
Multivalent Rhamnose‐Modified EGFR‐Targeting Nanobody Gains Enhanced Innate Fc Effector Immunity and Overcomes Cetuximab Resistance via Recruitment of Endogenous Antibodies
Authors: Li Yanchun , Lin Han , Hong Haofei , Li Dan , Gong Liang , Zhao Jie , Wang Zheng , Wu Zhimeng 
Published: January 2024

AbstractCetuximab resistance is a significant challenge in cancer treatment, requiring the development of novel therapeutic strategies. In this study, a series of multivalent rhamnose (Rha)‐modified nanobody conjugates are synthesized and their antitumor activities and their potential to overcome cetuximab resistance are investigated. Structure‐activity relationship studies reveal that the multivalent conjugate D5, bearing sixteen Rha haptens, elicits the most potent innate fragment crystallizable (Fc) effector immunity in vitro and exhibits an excellent in vivo pharmacokinetics by recruiting endogenous antibodies. Notably, it is found that the optimal conjugate D5 represents a novel entity capable of reversing cetuximab‐resistance induced by serine protease (PRSS). Moreover, in a xenograft mouse model, conjugate D5 exhibits significantly improved antitumor efficacy compared to unmodified nanobodies and cetuximab. The findings suggest that Rha‐Nanobody (Nb) conjugates hold promise as a novel therapeutic strategy for the treatment of cetuximab‐resistant tumors by enhancing the innate Fc effector immunity and enhancing the recruitment of endogenous antibodies to promote cancer cell clearance by innate immune cells.
Asymmetric price transmission in perishable crops value chain: A NARDL approach
Authors: Sharma Purushottam , Meena Dinesh Chand , Anwer Md. Ejaz 
Published: January 2024

AbstractPolicymakers and economists envisage effective price transmission across markets or stakeholders in supply chains as a vital contributor to market efficiency. The paper explores the vertical price transmission in the perishables supply chain in India using weekly data on farm, wholesale and retail prices collected from main production and consumption markets. We estimate the asymmetries in price transmission using the nonlinear autoregressive distributed lags model and found the asymmetry in both magnitude and speed in the case of wholesale–retail chain of Onion and Potato, asymmetry in magnitude in wholesale–retail chain of Tomato, and asymmetry in speed in farm–wholesale chain of Potato. The results of asymmetric coefficient, long‐run elasticity of price transmission, speed of adjustment and implied half‐life of disequilibrium indicated that farm–wholesale chain is more efficient than wholesale–retail chain. Further, market chains of Onion and Tomato are more efficient than Potato chains. The magnitude of the adjustment was found to be larger for the long‐run positive shock in wholesale–retail market chain of Onion, Potato and Tomato, and it concluded that retailers enjoy an advantage over wholesalers as well as farmers. We draw interesting policy considerations for the perishables sector [EconLit Citations: Q11, Q13, C32].
Treatment strategy for severe trauma patients requiring aortic occlusion for impending cardiopulmonary arrest in the hybrid emergency room
Authors: Maruyama Shuhei , Wada Daiki , Yoshihara Tomoyuki , Saito Fukuki , Yoshiya Kazuhisa , Nakamori Yasushi , Kuwagata Yasuyuki 
Published: January 2024

AbstractAimComputed tomography (CT) is useful in trauma care. Severely ill trauma patients may not tolerate whole‐body CT even without patient transfer. This study examined clinical flow of severe trauma patients requiring aortic occlusion (AO) such as resuscitative thoracotomy or REBOA in the hybrid emergency room (ER) and investigated patient clinical courses prioritizing CT first versus resuscitation including AO first.MethodsThis retrospective, single‐center observational study included consecutive trauma patients visiting our ER between May 2016 and February 2023. Patients were divided into the CT first group (whole‐body CT preceded AO) and AO first group (AO preceded whole‐body CT) and into two subgroups: AO after CT (AO/interventions for hemorrhage performed just after CT in the CT first group), and CT after AO (CT or damage control surgery performed after AO in the AO first group). We investigated 28‐day survival rates.ResultsSurvival probability by TRISS method was 49% (range: 3.3–94) in the CT first group (n = 6) and 20% (range: 0.7–45) in the AO first group (n = 7). Actual 28‐day survival rates were 50% and 57%, respectively. Survival rates of the AO after CT subgroup (CT first group) were 75% (3/4) and 0% (0/2), respectively, and those of the CT after AO subgroup (AO first group) were 25% (1/4) and 100% (3/3), respectively.ConclusionIn severe trauma patients with low predicted probability of survival treated in the hybrid ER, survival rates might be better if resuscitation including AO is performed before CT and if damage control surgery is performed first before CT.
Diphenylphosphinylhydroxylamine (DPPH) Affords Late‐Stage S‐imination to access free‐NH Sulfilimines and Sulfoximines
Authors: Gunasekera Shanal , Pryyma Alla , Jung Jimin , Greenwood Rebekah , Patrick Brian O. , Perrin David M. 
Published: January 2024

AbstractSulfilimines, as potential aza‐isosteres of sulfoxides, are valued as building blocks, auxiliaries, ligands, bioconjugation handles, and as precursors to versatile S(VI) scaffolds including sulfoximines and sulfondiimines. Here, we report a thioether imination methodology that exploits O‐(diphenylphosphinyl)hydroxyl amine (DPPH). Under mild, metal‐free, and biomolecule‐compatible conditions, DPPH enables late‐stage S‐imination on peptides, natural products, and a clinically trialled drug, and shows both excellent chemoselectivity and broad functional group tolerance. This methodological report is extended to an efficient and high‐yielding one‐pot reaction for accessing free‐NH sulfoximines with diverse substrates including ones of potential clinical importance. In the presence of a rhodium catalyst, sulfoxides are S‐iminated in higher yields to afford free‐NH sulfoximines. S‐imination was validated on an oxidatively delicate amatoxin to give sulfilimine and sulfoximine congeners. Interestingly, these new sulfilimine and sulfoximine‐amatoxins show cytotoxicity. This method is further extended to create sulfilimine and sulfoximine‐Fulvestrant and buthionine analogues.
Pulse Electrolysis Turns on CO2 Methanation through N‐Confused Cupric Porphyrin
Authors: Hua Wei , Liu Tingting , Zheng Zhangyi , Yuan Huihong , Xiao Long , Feng Kun , Hui Jingshu , Deng Zhao , Ma Mutian , Cheng Jian , Song Daqi , Lyu Fenglei , Zhong Jun , Peng Yang 
Published: January 2024

AbstractBreaking the D4h symmetry in the square‐planar M−N4 configuration of macrocycle molecular catalysts has witnessed enhanced electrocatalytic activity, but at the expense of electrochemical stability. Herein, we hypothesize that the lability of the active Cu−N3 motifs in the N‐confused copper (II) tetraphenylporphyrin (CuNCP) could be overcome by applying pulsed potential electrolysis (PPE) during electrocatalytic carbon dioxide reduction. We find that applying PPE can indeed enhance the CH4 selectivity on CuNCP by 3 folds to reach the partial current density of 170 mA cm−2 at >60 % Faradaic efficiency (FE) in flow cell. However, combined ex situ X‐ray diffraction (XRD), transmission electron microscope (TEM), and in situ X‐ray absorption spectroscopy (XAS), infrared (IR), Raman, scanning electrochemical microscopy (SECM) characterizations reveal that, in a prolonged time scale, the decomplexation of CuNCP is unavoidable, and the promoted water dissociation under high anodic bias with lowered pH and enriched protons facilitates successive hydrogenation of *CO on the irreversibly reduced Cu nanoparticles, leading to the improved CH4 selectivity. As a key note, this study signifies the adaption of electrolytic protocol to the catalyst structure for tailoring local chemical environment towards efficient CO2 reduction.