Characterization of Long COVID Definitions and Clinical Coding Practices
Authors: Maripuri Monika , Dey Andrew T , Honerlaw Jacqueline P , Hong Chuan , Ho Yuk-Lam , Tanukonda Vidisha , Chen Alicia W , Panickan Vidul Ayakulangara , Wang Xuan , Zhang Harrison G , Yang Doris , Samayamuthu Malarkodi Jebathilagam , Morris Michele , Visweswaran Shyam , Beaulieu-Jones Brendin R , Ramoni Rachel B , Muralidhar Sumitra , Gaziano Michael J. , Liao Katherine P , Xia Zongqi , Brat Gabriel A , Cai Tianxi , Cho Kelly 
Published: October 2023

AbstractBackgroundLong COVID characterized as post-acute sequelae of SARS-CoV-2 (PASC) has no universal clinical case definition. Recent efforts have focused on understanding long COVID symptoms and electronic health records (EHR) data provides a unique resource for understanding this condition. The introduction of the International Classification of Diseases (ICD)-10 code U09.9 for “Post COVID-19 condition, unspecified” to identify patients with long COVID has provided a method of evaluating this condition in EHRs, however, the accuracy of this code is unclear.ObjectiveOur study aimed to characterize the utility and accuracy of the U09.9 code across three healthcare systems - The Veterans Health Administration (VHA), Beth Israel Deaconess Medical Center (BIDMC) and The University of Pittsburgh Medical Center (UPMC) against patients identified with long COVID via a chart review by operationalizing the World Health Organization (WHO) and Centers for Disease Control (CDC) definitions.MethodsCOVID positive patients with either a U07.1 ICD code or positive polymerase chain reaction (PCR) test within these healthcare systems were identified for chart review. Among this cohort we sampled patients based on two approaches i) with a U09.9 code and ii) without a U09.9 code but with a new onset PASC related ICD code, which allows us to assess the sensitivity of the U09.9 code. To operationalize the long COVID definition based on health agency guidelines, we grouped symptoms into a “core” cluster of 11 commonly reported symptoms among long COVID patients and an extended cluster, that captured all other symptoms by disease domain.Patients having at least 2 symptoms persisting for >=60 days that were new onset after their COVID infection, with at least one symptom in the core cluster, were labeled as having long COVID per chart review. We compared the performance of the code across three health systems and across different time periods of the pandemic.ResultsA total of 900 patient charts were reviewed across 3 healthcare systems. The prevalence of long COVID among the cohort with the U09.9 ICD code, based on the operationalized WHO definition was between 23.2%-62.4% across these healthcare systems. We also evaluated a less stringent version of the WHO definition and the Centers for Disease Control (CDC) definition and observed an increase in the prevalence of long COVID at all three healthcare systems.ConclusionsThis is one of the first studies to evaluate the U09.9 code against a clinical case definition for long COVID, as well as the first to apply this definition to EHR data using a chart review approach on a nationwide cohort across multiple healthcare systems. This chart review approach can be implemented at other EHR systems to further evaluate the utility and performance of the U09.9 code.