bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiated thyroid cancer with osteo-granulomatous inflammation: a case report
Authors: Yan Zhihua , Cheng Bing , Wu Tong , Li Xiangzhou , Guo Mingzhen 
Published: December 2023

Abstract
Background: Cryptococcus, a genus of fungi, primarily includes Cryptococcus neoformans and Cryptococcus gattii, both known to cause human infections. Skeletal infections are rare, and there have been no reported cases of bone cryptococcal infection in conjunction with differentiated thyroid carcinoma.
Patient's main symptoms and key clinical findings: A 56-year-old female presented with a one-month history of "cough and throat irritation." Chest CT revealed scattered small nodules in both lungs, suggestive of metastasis. There was minimal inflammation in both lungs, and scattered lymph nodes were observed in the mediastinum and upper pulmonary hilum.
Main diagnosis, intervention, and major outcomes: The patient was diagnosed with differentiated thyroid carcinoma complicated by cryptococcal infection. Antifungal treatment with itraconazole 200mg/day was initiated, and after 3 months, clinical symptoms disappeared, with a reduction in lung nodules observed in follow-up chest CT.
Conclusion: When diagnosing distant metastasis in differentiated thyroid carcinoma, a comprehensive analysis combining imaging studies and serum thyroid globulin plays a complementary role, as illustrated in this case of differentiated thyroid carcinoma concurrent with cryptococcal infection.
Mitogenomes comparison of 3 species of Asparagus L shedding light on their functions due to domestication and adaptative evolution
Authors: Wu He , Dongchen Wenhua , Li Yunbin , Brown Sylvia E , Wei Shugu , Lin Chun , Mao Zichao , Liu Zhengjie 
Published: December 2023

Abstract

Background: Asparagus L., widely distributed in the old world is a genus under Asparagaceae, Asparagales. The species of the genus were mainly used as vegetables, traditional medicines as well as ornamental plants. However, the evolution and functions of mitochondrial (Mt) genome (mitogenome) remains largely unknown. In this study, the typical herbel medicine of A. taliensis and ornamental plant of A. setaceus were used to assemble and annote the mitogenomes, and the resulted mitogenomes were further compared with published mitogenome of A. officinalis for the analyses of their functions due to domestication and adaptative evolution.
Results: The mitochondrial genomes of both A. taliensis and A. setaceus were assembled as complete circular ones. The phylogenetic trees based on conserved coding proteins of Mt genomes and whole chloroplast (Cp) genomes showed that, the phylogenetic relationship of the sampled 13 species of Asparagus Lwere not exactly consistent. The collinear analyses between the nuclear (Nu) and Mt genomes confirmed the existence of mutual horizontal genes transferrings (HGTs) between Nu and Mt genomes among these species. Based on RNAseq data, the Mt RNA editing were detected and atp1 and ccmB RNA editing of A. taliensis were futher confirmed by DNA sequencing. Simultaneously homologous search found 5 Nu coding gene families including pentatricopeptide-repeats (PPRs) involved in Mt RNA editing were predicted in these species. Finally, the Mt genome variations, gene expressions and mutural HGTs between Nu and Mt were detected with correlation to their growth and developmental phenotypes respectively. The results suggest that, both Mt and Nu genomes coevoluted to maintain the Mt organella replication and meet requirements of energy production through TCA and oxidative phosphorylation among these species.
Conclusion: The assembled and annotated complete mitogenomes of both A. taliensis and A. setaceus provides valuable information for their phylogeny and concerted action of Nu and Mt genomes to maintain the energy production system of Asparagus L due to domestication and adaptation to environmental niches.
Assessment of spatial and temporal variations in the water quality of the Loktak Lake – Largest Ramsar Site in North-east India
Authors: Singh Thingujam Manithoi , Borah Rajtanaya , Goyari Sonali , Devi Ashalata , Malunguja Gisandu K 
Published: December 2023

Abstract
The present study was conducted in the Loktak lake which is the largest Ramsar site in the north-east India. In recent years, the lake has experienced a decline in its condition due to the accelerated process of urbanization, encroachment, high sedimentation, extensive use of chemical products and other anthropogenic activities. To assess the temporal water quality status, 38 sampling points were selected across the lake over four different seasons within a year. Twelve (12) physicochemical parameters like total alkalinity, calcium, chloride (Cl−), electrical conductivity (EC), dissolved oxygen (DO), total hardness, pH, phosphate (PO43−), salinity, sulphate (SO42−), total dissolved solids (TDS) and turbidity were analyzed using standard methods and instruments. The measured values of DO, EC, pH and turbidity were found beyond the desirable limits of BIS (Bureau of Indian Standards) and WHO (World Health Organization). This observation can be attributed to elevated levels of pollutants and microbiological processes. Lake water was ranged from slightly acidic to alkaline. High mean concentrations of EC (211.98) was found throughout the year. The study's findings indicate that the lake water exhibits a certain degree of pollution, necessitating appropriate treatment measures to ensure its suitability for both for domestic use and the preservation of wildlife. It is imperative to promptly develop effective management and conservation measures in order to mitigate the ongoing deterioration of water quality inside the lake and its associated ecosystem.
How ephapticity can explain brain complexity?
Authors: Cunha Gabriel Moreno , de Sousa Matheus Phellipe Brasil , Corso Gilberto , Lima Gustavo Zampier dos Santos 
Published: December 2023

Abstract
The origin of brain complexity remains an open question within the field of neuroscience. Although the acknowledged significance of synaptic stimuli, their efficacy frequently proves inadequate in explaining both the profound brain intricacies and refined levels of cognitive integration. Recent investigations in neuroscience have cast doubt on the mechanisms by which the brain generates highly complex, intricate dynamics, emergent patterns, and sophisticated oscillation signals. In this interesting context, our study, in line with contemporary research, postulates the hypothesis that ephaptic communication may emerge as the prime candidate to elucidate neuronal complexity. The present research carried out a comparative analysis between two types of networks using the Quadratic Integrate-and-Fire-Ephaptic model: (I) a small-world synaptic network and (II) a mixed composite network comprising a small-world synaptic network augmented by an ephaptic network. We employ the Multiscale Scale Entropy approach to examine the responses of both networks, with complexity estimated by summing across all temporal scales. The outcomes clarify that ephaptic coupling amplifies complexity under specific conditions, taking into account variables such as timescale and synaptic intensity. These results may provide new insights into the balance of nervous system communications and underscore the fundamental role of ephapticity in orchestrating complex brain functions. Consequently, our research significantly contributes to advancing a deeper understanding of the intricate, complex dynamics inherent in brain activities.
Seasonal patterns in melasma incidence and correlation to Google Trends search volume: A cross-sectional analysis
Authors: Getachew Ethiopia , Kamal Kanika , Young Katherine , Xiang David , Semenov Yevgeniy , Mostaghimi Arash , Theodosakis Nicholas 
Published: December 2023

Abstract
Melasma is a hyperpigmenting disorder primarily affecting darker-skinned individuals and women of reproductive age. Melasma has being associated with photoaging and sun exposure. As such, in this study we investigate seasonal trends in melasma diagnoses, considering race and ethnicity, and seasonal Google search trends. We utilized the Mass General Brigham Research Patient Data Registry (RPDR) and Google Trends data from 2015 to 2022. Among 3,895 melasma patients identified in RPDR, the mean age of diagnosis was 43.9 years. We found the highest melasma incidence was seen in Fall, especially among White, Asian, and Hispanic patients. Black patients exhibited dual peaks in incidence in both the Spring and Fall. Google Trends search data showed increased search during Summer, suggesting a delay between melasma development, and therefore searches, and formal dermatologist evaluation. Overall, this study highlights the seasonal periodicity of melasma and underscores the importance of year-round sun protection and counseling for individuals of all Fitzpatrick skin types.
WITHDRAWN: Effect of DMSO@γ-Fe2O3 nanomagnetic fluid thermotherapy combined with docetaxel on the biological behavior of human gastric cancer AGS cells under the alternating magnetic field
Authors: li chunyan , yang xiaojun 
Published: December 2023

Abstract
Objective
To study the effects of DMSO@γ-Fe2O3 nanomagnetic fluid thermotherapy combined with the chemotherapeutic drug docetaxel on the biological behavior of human gastric cancer AGS cells under an alternating magnetic field of a certain intensity.
Methods In vitro warming experiments were performed on DMSO@γ-Fe2O3 nanomagnetic fluid under an alternating magnetic field to determine the optimal temperature (43.5°C) required for nanomagnetic fluid thermotherapy. Human gastric cancer AGS cells were divided into control, nanomagnetic fluid thermotherapy, chemotherapy and nanomagnetic fluid thermotherapy combined with chemotherapy groups (referred to as the thermo-chemotherapy group). The CCK8 assay was used to evaluate the inhibitory effect of DMSO@γ-Fe2O3 nanomagnetic fluid on AGS cells and to determine the working concentration of docetaxel on AGS cells; A cell scratch assay was performed to explored the cell migratory movements of cell groups, and a transwell assay was performed to test the invasion of each group of cells and flow cytometry to detect apoptosis of cells in each group.
Results The warming effect of DMSO@γ-Fe2O3 nanomagnetic fluid was good, and when the concentration of DMSO@γ-Fe2O3 nanomagnetic fluid was ≥ 7 g·Ｌ–1, the temperature could reach over 43.5℃. The drug concentration at 24h IC50 was used as the working concentration for the experiment, and the working concentration of docetaxel was determined to be 0.20 mM. Both nanomagnetic fluid thermotherapy alone at 43.5 ℃ and chemotherapy alone had inhibitory and killing effects on AGS cells (P < 0.05), and the flow cytometry results showed that the apoptosis rates of the control group, the nanomagnetic fluid thermotherapy group, the chemotherapy group, and the thermochemotherapy group were 6.11 %, 17.67 %, 20.21 % and 43.80 %.
Conclusion Under the effect of alternating magnetic field, DMSO@γ-Fe2O3 nanomagnetic fluid thermotherapy (43.5°C) could significantly enhance the inhibitory effect of the chemotherapeutic drug docetaxel on AGS cells.
An Innovative Multi-Omics Model Integrating Latent Alignment and Attention Mechanism for Drug Response Prediction
Authors: Cui Yuan-Chi , Chen Hui-O , Lin Peng-Chan , Chiang Jung-Hsien 
Published: December 2023

Abstract
Background
Using omics, we are now able to examine all components of biological systems simultaneously. Omics can influence treatment decisions, enhancing clinical outcomes. Deep learning-based drug prediction methods have shown promise by integrating cancer-related multi-omics data. However, The complex interaction between genes poses challenges in accurately projecting multi-omics data. In this research, we present a predictive model for drug response that incorporates diverse omics data, comprising genetic mutations, copy number variations, and methylation, along with gene expression data. This study proposes latent alignment as a solution for information mismatch in integration, achieved through an attention module capturing interactions among diverse omics data.
Results:
The latent alignment and attention modules significantly improve predictions, outperforming the baseline model with MSE = 1.1333, F1-score = 0.5342, and AUROC = 0.5776. It demonstrated high accuracy in predicting drug responses for Piplartine and Tenovin-6, while accuracy was comparatively lower for Mitomycin-C and Obatoclax. This observation aligns with the notion mentioned in our previous experiment that the methylation and expression datasets make a meaningful contribution to predicting drug response. The latent alignment module exclusively outperforms the baseline model, enhancing MSE by 0.2375, F1-score by 4.84%, and AUROC by 6.1%. Similarly, the attention module only improves these metrics by 0.1899, 2.88%, and 2.84%, respectively. In the interpretability case study, Panobinostat, an HDAC2 inhibitor, exhibited the most effective predicted response with a value of -4.895.
Conclusion:
By integrating multiple omics data effectively, we improve prediction accuracy and interpretability. We provide reliable insights for drug selection in medical decision-making by identifying crucial genetic factors influencing drug response.
Compacting cities and conserving large green spaces reduce the negative effects of the urbanization on functional diversity of birds
Authors: Campus-Silva Lucas Andrei , Toppa Rogério Hartung , Piratelli Augusto João 
Published: December 2023

Abstract
Urban sprawl occurs through different models, causing physical, social, and environmental changes, that may have diverse effects on biological communities. In this paper, we tested the effects of land sharing and land sparing urban sprawl models along a gradient of urbanization, composed by rural area, urban sprawl models and urban core, in southeastern Brazil. We specifically assessed the size of the urban green and gray spaces and bird taxonomic and functional diversity. We hypothesize that there are differences across this gradient in relation to (a) the amount of green and gray spaces; and (b) bird functional diversity. We also hypothesize that (c) the size of the green and gray spaces affects bird functional diversity, and (d) rural settlements harbor larger and smaller areas of green and gray spaces, respectively, leading to an increasein the taxonomic and functional diversity. We predict that the land-sparing urban model (a) will have larger areas of green spaces and (b) higher functional diversity of birds. In addition, (c) the size of green and gray urban spaces is positively and negatively related to the functional diversity of birds, respectively. We found differences along the gradient of urbanization concerning the functional diversity of birds. Furthermore, the sparing model proved to be more suitable. Green and gray spaces had positive and negative effects on functional diversity, respectively. Our findings have significant implications for urban plannings, aimed at the selection of urban sprawl models that balance urban development, and conservation of larger green spaces.
Analysis of the early evolution of the Twitter (X) social network in Sub-Saharan Africa
Authors: Levens Watson , Sumpter David J. T , Mujuni Egbert , Amour Idrissa Said 
Published: December 2023

Abstract
In sub-Sahara African countries the proportion of the population using Twitter (now known as X) and other social media networks is growing. Understanding these networks allows us to understand changes in how people interact with each other, share information and carry out economic transactions. We hypothesise that the networks of sub-Sahara African Twitter networks have statistical properties consistent with being built on a principle of self-organisation: where decisions about who to connect to are less influenced by large commercial actors (as they might be in Europe, USA and other parts of the world) and are instead on the basis of local interactions between individuals. To test this hypothesis, we first collected data on the Twitter network of users in Tanzania. We found that the degree distribution followed a power-law with degree close to 2. We calculated path lengths, clustering, and assortativity of mixing for this network, as well as identifying the most influential users using eigenvector centrality. We then tested the degree to which these measurements were consistent with a variation of a friend-of-a-friend model of network attachments: where links are formed by individuals who join a network first identifying one individual at random (a friend) and attach to them and then choose nq people who the initial individual follows and attach to each of them with probability q. We found that for q = 1 and nq = 40 the model reproduces many aspects of the Tanzanian network, including the degree and clustering distribution. This model is not consistent with, for example, the USA or Japanese Twitter networks. Taken together, the model and its comparison to data from different real world network, supports the self-organisation hypothesis: a rule under which new members of the network connect to a random person and 40 people they follow reproduces many aspects of how the Tanzanian Twitter network has grown.
screening for fabry disease in patients on hemodialysis
Authors: batta gaurav 
Published: December 2023

Abstract

BackgroundFabry disease is an under-recognized X-linked lysosomal storage disorder characterized by the accumulation of trihexosylceramides in multifarious tissues, leading to end-organ damage, including progressive renal failure. Antecedent screening studies worldwide have shown inconsistent prevalence in hemodialysis population. We conducted this study to screen for Fabry disease in patients undergoing dialysis at a tertiary care hospital.MethodsAll patients undergoing dialysis were screened with a gal assay using dried blood spots (DBS) on filter paper using the fluorescence method. Patients with positive DBS test results were further tested for underlying mutations.ResultsA total of 112 patients (64.3% males, 35.7% females) on dialysis were screened. 19 patients (13 males, 6 females) were found to have low enzyme activity on DBS. Further mutation analysis confirmed that one female patient had Fabry disease. The mutation detected was a heterozygous missense variation in exon 7 of the GLA gene, which resulted in the amino acid substitution of histidine for arginine at codon 363 (p. Arg363His). Subsequent screening of the family members revealed that the son of the patient was asymptomatic and carried the same genotypic mutation. Genetic counselling was performed, and ERT was offered to both patients.ConclusionsFabry disease remains underdiagnosed, especially in high-risk populations such as those undergoing dialysis. DBS is a convenient and effective screening tool for Fabry disease. Facilities should be augmented for similar screening studies in the dialysis population.
Exploring the role of artificial intelligence and inclusive technologies during navigation-based tasks for individuals who are blind or who have low vision: Future directions and priorities.
Authors: Martiniello Natalina , Bleau Maxime , Gingras-Royer Nathalie , Tardif-Bernier Catherine , Nemargut Joseph Paul 
Published: December 2023

Abstract
Background
Mainstream smartphone applications are increasingly replacing the use of traditional visual aids (such as hand-held telescopes) to facilitate independent travel for individuals who are blind or who have low vision.
Objective
The goal of this study was to explore the navigation-based apps used by individuals who are blind or low vision, the factors influencing these decisions, and perceptions about gaps to address future needs.
Methods
An international online survey was conducted with 139 participants who self-identified as blind or low vision (78 women, 52 men) between the ages of 18 and 76.
Results
Findings indicate that the decision to use an app based on artificial intelligence versus live video assistance is related to whether the task is dynamic or static in nature. Younger participants and those who are congenitally blind are significantly more likely to employ apps during independent travel. Although a majority of participants rely on apps only during unfamiliar routes (60.91%), apps are shown to supplement rather than replace traditional tools such as the white cane and dog guide. Participants underscore the need for future apps to better assist with indoor navigation and to provide more precise information about points of interest.
Conclusions
These results provide vital insights for rehabilitation professionals who support the growing population of clients with acquired and age-related vision loss, by clarifying the factors to consider when selecting apps for navigation-based needs. As additional technology-based solutions are developed, it is essential that blind and low vision individuals, including rehabilitation professionals, are meaningfully included within design.
Wastewater treatment by microalgae-based processes
Authors: Acien F. G. , Gómez C. , Morillas A. , Zouhayr A. , Sanchez A. , Nordio R. , Rodriguez E. , Guzman J. L. , Fernández-Sevilla J. M. 
Published: December 2023

Abstract
This chapter summarizes the status, major challenges and potential contribution of microalgae-related wastewater treatment processes. Although the use of microalgae for wastewater treatment was proposed in the last century, technology was not sufficiently efficient and robust to be applied at a commercial scale. Only recent advances in the knowledge of biological systems, the engineering of reactors and the harvesting and processing of the produced biomass allow the development of the first industrial demonstrations. Facilities of several hectares are already in operation demonstrating the feasibility of this technology. However, challenges remain for the further improvement and enlargement of these systems. They are related to (1) the improvement of knowledge and management of biological systems, (2) the development of adequate strategies for the allocation and implementation of large-scale facilities, (3) the definition of optimal operation conditions including the development of non-assisted systems capable of operating under variable environmental conditions and (4) the development of adequate routes for the valorization of biomass. Much effort is being devoted to solving these challenges and thus making this technology reliable for industrial applications. Once it is achieved, the use of microalgae will be incorporated into the portfolio of available technologies for wastewater treatment. In this respect, no single technology is capable of solving all the scenarios related to wastewater treatment, but microalgae-related processes represent a semi-intensive technology capable of contributing to efficiently treating wastewater while recovering nutrient-energy-water scenarios related to temperate climates with no severe land restrictions. Moreover, the use of microalgae represents a change of paradigm in the field of wastewater treatment because by using this type of microorganisms it is possible to produce valuable biomass at a higher price than the wastewater treatment cost. The potential of microalgae-related wastewater treatment processes is thus highly relevant, and valuable to achieve the sustainable development goals defined by the United Nations.