bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective Potential of Vitamin B-12 Against Cadmium–Induced Neuroinflammation Mediated Memory Dysfunctions in Adult Albino Mice
Authors: Yousaf Mohammad , Javed Fiaza , Jawad Sahibzada Muhammad , Naz Rukhsana , Anam Anam , Ullah Izhar 
Published: October 2023

Cadmium induces neurotoxicity in brain and results in increased enzymatic functions, accumulation of Amyloid beta plaque and Neuo Fibrillary Tangles (NFTs) causing neurodegenerative diseases. The purpose of the present work was to investigate the anti-inflammatory or anti-oxidative potential of vitaminB12 against Cd -induced memory impairment and mechanism of signaling pathway of vitamin-B12 protection in Cd-induced neuroinflammatory in mice model. Male albino mice of BALB/C trait of age 7 to 8 weeks and weighing about (30-32±3g) were used as model animal in the study. All mice were divided in three groups. Control Group (CG) treated with 0.9% saline (1mL/Kg), Cd Cl2 administered Group (CD) (1mg/kg) and Cd +Vitamin administered group (CV) B-12 (500µg/kg). CD group was treated with Cd Cl2 for three weeks on alternate days while CV group was treated with Vitamin B12 and toxin CdCl2 for the next two weeks intraperitonealy. Behavior tests like Morris Water Maze (MWM) and Y-Maze (YM) tests were conducted on the experimental mice to study the neuro protective potential of Vitamin-B12 against CdCl2 induced memory dysfunctions. After completing the above procedures, mice were sacrificed and the brains of each group were collected for protein quantification step and western blotting. The Immuno blots of Iba-1, NF-kB, TNF-α, IL-1β, BACE1 and Aβ proteins in the brain homogenates of CD and CV mice confirm the anti-neuroinflammatory potential of vitamin-B12 against Cadmium –induced Neuroinflammation. Escape latency of CV group mice receiving Methylcobalamine was less and showed better performance in MWM test. The results of Y-maze test also showed that the spontaneous percentage alternation of CD group mice was less than CV and CG group of mice. Immuno blot of p-Akt confirm the signaling pathways of vitamin-B12 protection in Cd-induced neuroinflammatory mediated memory-impairment in the model mice. Our findings suggest that Vitamin-B12 could be a potent candidate drug for treating cognitive dysfunctions due to its anti-inflammatory and anti-oxidative potential. Our study also shows that Vitamin-B12 activates p-Akt signaling pathway along with decreasing the NF-Κb, TNF-α and IL-1β to protect the brain of mice against CdCl2 neurotoxicity.
A Diabetes-Specific Questionnaires Validated in Indonesia: A Systematic Review
Authors: Panduwiguna Ivans , Rani Sauriasari  , Ratu Ayu Dewi Sartika  , Woro Riyadina  
Published: October 2023

Diabetes is a global problem that is increasingly higher from year to year. Diabetes-specific instruments so far can be well received by patients to evaluate specific aspects of their diabetic disease. This instrument is believed to be one of the best methods to evaluate certain characteristics in diabetic diseases. The purpose of the research is to identify and compare all validated diabetes-specific questionnaires. Researchers performed searches on three different electronic databases: PubMed, ScienceDirect, and Google Scholar. The study was selected covering cross-cultural adaptation and validation methodologies in Indonesia with type 1 and type 2 diabetes patients of all ages. After reviewing the full-text article, data related to psychometric characteristics are extracted from each selected study. Reliability is rated with Cronbach's (Cα). The initial search identified 1,576 studies. After the exception, 45 studies were put in for review. The questionnaires were grouped into 12 domains based on the focus of the study: adherence (n = 15), quality of life (n = 9), diabetes knowledge (n = 6), self-efficacy (n = 9), Attitude to diabetes (n = 2), emotional stress (n = 8), expectations (n = 1), perception of disease severity (n = 1), risk of developing diabetes (n = 1), family support (n = 3), diet (n = 1) and religiosity (n = 1)This study identifies and reviews all diabetes-specific questionnaires that have been validated for Indonesians to facilitate researchers to select the most appropriate instrument for each domain of interest in future research and clinical settings.
О текстах Манджушри из Научного архива Калмыцкого научного центра РАН (по материалам коллекции Э. Б. Убушиева)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Muzraeva Deliash N. 
Published: October 2023

Introduction. The study of the pantheon of deities — along with the corpus of related texts once used by Kalmyk Buddhists — is still an underdeveloped field of Oriental studies. The image of bodhisattva Manjushri is a most revered one among Kalmyk followers of Tibetan Buddhism. Goals. The article aims to describe, transliterate and translate a sample narrative reflecting the cult of veneration of the mentioned bodhisattva. Materials. The text is one of the many written sources once donated by E. B. Ubushiev (Agvan Tabdan). Results. The article provides a list of texts dedicated to Manjushri in the Kangyur, in translations authored by Ven. Zaya Pandita Namkhai Jamtso, and also briefly reviews some Manjushri-related texts currently included in Kalmykia’s collections. The completed translation of the Dhāraṇī Sworn by Manjushri, as well as another text to be mentioned (Instructions [Delivered] by Saint Manjushri), may serve as vivid evidence of the reverence this deity of the Buddhist pantheon is granted by the Kalmyks.
Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology
Authors: Shin Jean , Patel Yash , Parker Nadine , Paus Tomas , Pausova Zdenka 
Published: October 2023

OBJECTIVE
To investigate the relationship between blood glycated hemoglobin (HbA1c) and cerebral cortical thickness (CT) and identify potential cellular mechanisms involved.

RESEARCH DESIGN AND METHODS
A cohort of 30,579 adults age 45 to 81 (mean ± SD: 64 ± 7.5) years with available data on brain MRI and blood HbA1c levels was analyzed. The relationship between HbA1c and CT was probed using independent spatial profiles of cell-specific gene expression. Lastly, a genome-wide association study was conducted on the shared variance between HbA1c and CT.

RESULTS
The HbA1c–CT association was noncontinuous, emerging negatively within the prediabetic range (39.6 mmol/mol). This association was strongest in brain regions with higher expression of genes specific to excitatory neurons and lower expression of genes specific to astrocytes and microglia. A significant locus implicated mitochondrial maintenance and ATP generation.

CONCLUSIONS
Effective glycemia control at prediabetic levels is warranted to preserve brain health and prevent prediabetes-related neurobiologic perturbations.
PENGARUH PENGGUNAAN MEDIA BERBASIS VISUAL TERHADAP KEMAMPUAN MENULIS PUISI OLEH SISWA KELAS VIII MTs SWASTA BANDAR KHALIFAH TAHUN AJARAN 2014/2015
Authors: Hariyani Hariyani , Surip Muhammad 
Published: October 2023

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruhPenelitian ini bertujuan untuk mengetahui pengaruh penggunaan media berbasis visual dalam meningkatkan kemampuan menulis puisi siswa kelas VIII MTs Swasta Bandar Khalifah Tahun Ajaran 2014/2015.Populasi penelitian ini adalah seluruh siswa kelas VIII MTs Swasta Bandar Khalifah Tahun Ajaran 2014/2015, yang berjumlah 133 orang yang menjadi sampel penelitian ini 31 orang. Pengambilan sampel dilakukan dengan cara menentukan satu kelas yang di jadikan wakil populasi untuk diteliti. Dari pengolahan data, diperoleh nilai rata-rata Pretest 64,52, standar deviasi 6,26, penyebaran nilai siswa terbanyak adalah 65 sebanyak 9 orang atau sekitar 29,03%. Nilai rata-rata postest 78,06, standar deviasi 7,15 penyebaran nilai siswa terbanyak adalah 75 sebanyak 7 orang atau sekitar 20,59%. Berdasarkan uji ini normalitas hasil pre-test dan pos-test dinyatakan berdisibusi normal. Kemudian, berdasarkan uji homogenitas dinyatakan bahwa sampel berasal dari populasi yang homogen. Setelah uji normalitas dan homogenitas dilakukan, maks diketahui t0 sebesar 4,83. Selanjutnya t0 dikonstultasikan dengan tabel t pada taraf singnifikan 5% dengan df = n -1 = 31 -1 = 30 diperoleh taraf signifikan 5% sebesar 2,04. Berdasarkan perhitungan yang telah dilakukan, maka dapat diketahui t0>ttabel, yakni 7,83> 2,04. Dengan demikian H0 (hipotesis nihil) ditolak dan Ha (hipotesis alternatif) diterima. Hal ini membuktikan bahwa ada pengaruh penggunaan media berbasis visual dalam meningkatkan kemampuan Menulis puisi siswa kelas VIII MTs Swasta Bandar Khalifah tahun ajaran 2014/2015. Kata Kunci: Media Berbasis Visual, Menulis Puisi Puisi.
PENGARUH PENGGUNAAN MEDIA GAMBAR BERSERI TERHADAP KEMAMPUAN MENULIS BERITA SISWA KELAS VIII SMP PGRI 9 PERCUT SEI TUAN TAHUN PEMBELAJARAN 2015/2016
Authors: Hafiza Hafiza , Siregar Rosdiana 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan media gambar berseri terhadap kemampuan menulis berita oleh siswa kelas VIII SMP PGRI 9 Percut Sei Tuan Tahun Pembelajaran 2015/2016. Populasi penelitian ini berjumlah 140 siswa SMP PGRI 9 Percut Sei Tuan. Sampel diambil secara random sampling (acak kelas), yaitu sebanyak 35 siswa kelas VIII-1. Metode yang digunakan dalam penelitian ini adalah metode eksperimen one-group pretest-posttest design. Instrumen yang digunakan untuk menjaring data adalah tes essay dalam bentuk penugasan yaitu menulis puisi. Pengujian hipotesis dilakukan dengan menggunakan uji “t”. Metode dalam penelitian ini menggunakan desain eksperimen yang dilaksanakan pada satu kelompok saja tanpa kelompok pembanding. Hasil penelitian menunjukkan bahwa kemampuan siswa dalam menulis berita sebelum menggunakan media gambar berseri termasuk dalam kategori cukup dengan nilai rata-rata 61,6 sedangkan sesudah menggunakan media gambar berseri termasuk dalam kategori baik dengan nilai rata-rata 81,9. Selanjutnya pengujian hipotesis menunjukkan thitung > ttabel atau 15,38 > 2,03 pada taraf signifikan = 0,05. Dengan demikian, telah terbukti bahwa hipotesis nihil (Ho) ditolak dan hipotesis alternatif (Ha) diterima yaitu ada pengaruh yang signifikan terhadap media gambar berseri dalam menulis teks berita. Hal ini membuktikan bahwa media gambar berseri berpengaruh yang signifikan terhadap kemampuan menulis teks berita siswa kelas VIII SMP PGRI 9 Percut Sei Tuan tahun pembelajaran 2015/2016. Kata Kunci: Media Gambar Berseri, Kemampuan Menulis Berita.
PENERAPAN MODEL PEMBELAJARAN COOPERATIVE TYPE JIGSAW UNTUK MENINGKATKAN KEMAMPUAN MENULIS RESENSI CERPEN SISWA KELAS XI SMA NEGERI 1 PANYABUNGAN TAHUN PEMBELAJARAN 2015/2016
Authors: Fatimah Siti , Gafari M. Oky Fardian 
Published: October 2023

Abstrak Penelitian ini bertujuan untuk mendeskripsikan peningkatan kemampuan menulis resensi cerpen pada siswa kelas XI SMA Negeri 1 Panyabungan setelah menerapkan model pembelajaran cooperative type jigsaw. Penelitian ini menggunakan metode penelitian eksperimen dengan model one group pretest-posttest design. Populasi penelitian ini adalah seluruh siswa kelas XI SMA Negeri 1 Panyabungan yang berjumlah 240 siswa, yaitu kelas XI IPA 1, XI IPA 2, XI IPA 3, XI IPA 4, XI IPS 1, XI IPS 2, dan XI IPS 3. Sampel penelitian ini diambil dengan cara random sampling yaitu kelas XI IPA 2 yang berjumlah 33 orang. Data diperoleh dengan cara membuat instrument essay, yaitu menulis resensi cerpen. Berdasarkan hasil analisis data kemampuan menulis resensi cerpen siswa sebelum menerapkan model pembelajaran cooperative type jigsaw masih rendah atau kurang. Hal ini dibuktikan dengan nilai rata-rata yang diperoleh siswa pada saat dilakukannya pre test yakni 63,21 dengan nilai tertinggi 71 dan nilai terendah 56. Kemudian setelah menerapkan model pembelajaran cooperative type jigsaw meningkat. Hal ini dibuktikan dengan nilai rata-rata yang diperoleh siswa pada saat dilakukannya pre test yakni 80,91 dengan nilai tertinggi 88 dan nilai terendah 73. Dengan demikian dari hasil penelitian, penerapan model pembelajaran cooperative type jigsaw dapat meningkatkan kemampuan siswa dalam menulis resensi cerpen. Hal ini dibuktikan dengan nilai posttest dibandingkan dengan nilai pretest menunjukkan peningkatan. Hasil posttest diperoleh nilai rata-rata 80,91 sedangkan nilai rata-rata pretest yaitu 63,21. Dengan demikian telah terjadi peningkatan sebesar 17,7 poin atau telah mengalami peningkatan sebesar 28%. Maka dapat disimpulkan bahwa penerapan model pembelajaran Cooperative Type Jigsaw dapat meningkatkan kemampuan menulis resensi cerpen siswa kelas XI SMA Negeri 1 Panyabungan Tahun Pembelajaran 2015/2016. Kata Kunci: Kemampuan menulis resensi cerpen, Model Pembelajaran Cooperative Type
Analisis Film Cinta Pertama, Kedua dan Ketiga Ditinjau dari Segi Representasi Makna
Authors: Ismi Fatimah , Qura Ummul 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui struktur tanda menurut Charles Sanders Pierce dan juga representasi makna yang terdapat dalam Film Cinta Pertama, Kedua dan Ketiga. Film ini merupakan film bergenre romantis, dengan mengangkat tema tentang keluarga dan percintaan menjadi nilai penting dalam film ini untuk menarik eksistensi di zaman sekarang. Penelitian ini menggunakan metode kualitatif deskriptif dengan teknik simak catat. Penelitian ini menggunakan pendekatan semiotik berdasarkan teori Charles Sanders Pierce yaitu ikon, merupakan tanda yang memiliki hubungan kemiripan antara penanda dan pertandanya; indeks, merupakan tanda keterkaitan sebab-akibat antara penanda dan pertandanya; simbol, merupakan tanda yang tidak memiliki keterkaitan antara penanda dan pertandanya. Hasil penelitian ini memiliki 11 data yang mendeskripsikan tentang struktur tanda dan representasi makna pada Film Cinta Pertama, Kedua dan Ketiga. Kata Kunci: Representasi Makna, Semiotik, Film
The Relationship Between Helicobacter pylori Infection and Development of Rheumatoid Arthritis
Authors: Khalid Suhaib 
Published: October 2023

Background : Helicobacter pylori is a spiro-helical, gram-negative & microaerophilic bacteria that particularly lives in the stomach. It has helix form is thought to have developed to puncture the mucoid lining of the stomach and transmit infection. Almost around world about half of population infected with these bacteria, which is broadly dispersed. The interplay of genetic predisposition and environmental exposures results in autoimmune disorders. Infectious triggers have been linked and thoroughly explored among environmental exposures.
Purpose: To identify the frequency of peoples infected with Helicobacter pylori with autoimmune disorders like rheumatoid arthritis and to determine how this infection may affect the immune system and contribute to autoimmune disease.
Methods: 100 Stool samples were collected from patients (50) & control group (50) having mild to severe abdominal symptoms also they have pain in joints and bones in order to detect H. pylori infection by stool antigen (Ag) test also urea breath test done to confirm the diagnosis , the patients also diagnosed for rheumatoid arthritis (RA) via anti -CCP test by blood samples collection .
Results: 50 total patients were infected by H. pylori , Females have higher rate of infection with 60% and males 40% . (40-49) years old age patients have higher rate of infection . (30%) of patients with positive H. pylori and chronic gastritis suffered from Pain in bones and joints and diagnosed with RA , while only 6 % of controls without H. pylori infection diagnosed with RA and showed less gastrointestinal symptoms and no joints inflammation.
Conclusions: In our study we can conclude that there is a strong association between gastritis in patients caused by helicobacter pylori and development of autoimmune diseases represented by rheumatoid arthritis .
Gene expression levels of inflammatory mediators in diabetic foot ulcer patients
Authors: Hussein Israa K. , Shani Wafaa S. 
Published: October 2023

Background: Diabetic foot ulcer (DFU) is a common serious complication of diabetes. Nowadays there is a suggestion that referred to the fact
the chronicity of DFU is a result of the positive feedback of proinflammatory cytokines production. Objective: This study aimed to display the negative effects of persistent expression of proinflammatory cytokines of (IL-1β and IL-18) under hyperglycemic condition on the DFU microenvironment and clarify the role of growth factor Milk fat globule-epidermal growth factor- 8( MFG-) in the DFU healing process. Approach: Clinical data of a total of 49 type 2 diabetic patients have chronic diabetic foot ulcer grade 2 and 3 (infected DFU n= 29 and non-infected n=21) in addition to the control group (n=25) were participated in the study since June 2021 to April 2022 , venous blood samples were collected for the measurement of the gene expression levels of (IL-1β ; IL-18 and MFG-E8) by Real-Time PCR technique . Results: There was no significant difference in age and sex when compared with the control group at p= 0.798, p =0.514 respectively. High levels of gene expression of (IL-1β ; IL-18 and MFG-E8) were shown in the patients group in comparison to the healthy control.
Conclusions: Current data confirmed that the inflammatory mediators’ (IL-1β ; IL-18 and MFG-E8) have a strong association with the pathogenesis of DFU healing process.
Popularization of Medical Knowledge in German Journal Discourse in Perspective of Language Code
Authors: Tayupova O. I. , Tayupova I. M. 
Published: October 2023

A study was conducted on the language code used in medical popular science texts in German journal discourse. Interviews, brief news texts, and articles on medical topics are used as empirical material. It is shown that the arsenal of modern German language resources is aimed at implementing communicative-pragmatic functions of popular science discourse texts as a whole. It is noted that the leading functions among them are informing, influencing, and persuading the target audience. It is established that verbal means of different linguistic levels, as well as a number of stylistic devices (inversion, parceling, allusion, metaphor, metonymy, personification), not only convey medical knowledge to wide segments of the population but also transmit information about the national-cultural specifics of Germany and its achievements in medicine, taking into account the age characteristics of the addressees, also performing an educational function and seeking to achieve emotional involvement of the reader in complex content. The relevance of the study is due to the growing interest of non-professional participants in media-medical communication in the processes of self-diagnosis and self-treatment, which require mastering various medical knowledge. The novelty of the research lies in determining the pragmatic potential of structural-compositional features, including clickable headlines, and linguistic means, thanks to which a special media-medical picture of the world is formed.
Motifs of Fyodor Dostoevsky’s ‘Notes from Dead House’ in Hans Fallada’s Novel ‘Wer einmal aus dem Blechnapf frißt…’
Authors: Melnikova L. A. 
Published: October 2023

The novels ‘Notes from the Dead House’ by Fyodor Dostoevsky and ‘Wer einmal aus dem Blechnapf frißt…’ (‘Who Once Drinks from the Prison Chalice’) by Hans Fallada are analyzed in terms of literary connections. The relevance of the study is due to the need for a comprehensive and multifaceted examination of Hans Fallada’s literary dialogue with Fyodor Dostoevsky. A number of similar motifs are identified, as well as the fact that there are allusive “cross-references” between the characters of the novels. It is noted that both authors show the destructive influence of imprisonment on the criminal’s personality. It is emphasized that in both novels, the criminal is deprived of the ability for spiritual revival, and the writers criticize the unjust social system that pushes the “little” person to break the law. Drawing on the traditions of Fyodor Dostoevsky, Hans Fallada shows in his novel that life for prisoners, both in prison and after release, is akin to being in a “dead house”, as it deprives the “humiliated and insulted” heroes of the opportunity to change their fate. It is concluded that comparing the novels “Notes from the Dead House” and “Who Once Drinks from the Prison Chalice” allows for identifying similarities in their ideas and outlining perspectives for further research on the reception of Fyodor Dostoevsky’s artistic experience in Hans Fallada’s work.
Trends in Development of Modern Siamese Literature
Authors: Saengnateswang V. A. 
Published: October 2023

The processes of development of a new type of Siamese (Thai) literature are being considered, the gradual formation of which is attributed to the second half of the 19th century. Special attention is paid to the changes in the principles of redistribution of literary microsystems (genres) and the main types of literary art (poetry and prose) in the literary system of Siam. The key events that influenced the simplification of the artistic language of the new type of literature compared to its representation in traditionalist (classical) texts are briefly highlighted. The relevance of the research, related to its objectives, is seen in updating and supplementing the accumulated initial data and knowledge about Siamese (Thai) literature during its transition from a medieval type to an individual-creative one by Soviet and Russian philological science. The novelty of the research is due to the inclusion of information on the development of new Siamese literature, previously not presented in domestic scientific literature. It is proven that changes in the principles of redistribution of fundamental categories of poetics in Siamese (Thai) literature occurred in connection with its renewal and enrichment with new “foreign” forms that came from European literatures and were filled with content relevant to the Siamese literature’s perception.
Rumors and Conversations in Kazakh Village (Aul) on Eve of Famine (1927—1931)
Authors: Ablazhey N. N. , Zhanbossinova A. S. , Sailaubay E. E. 
Published: October 2023

The social phenomenon of “rumors and gossip” in a Kazakh village during the 1920s-1930s is analyzed in this study. It is emphasized that rumors are an integral part of traditional society. It is asserted that the massive surge of rumors in Soviet Russia was a reaction of traditional society to forceful modernization. The goal of the article is to demonstrate the dichotomy of the content and form of rumors during the collectivization period in relation to the Kazakh village (aul). It is noted that the analytical materials of the OGPU are the most important source for studying the mood of the population of the USSR in the 1920s — early 1930s, which found reflection in rumors. It is shown that accelerated Sovietization generated a high level of anxiety in Kazakh society, reflected in the rise of apocalyptic moods and the actualization of mythology. The authors conclude that the idea of kiyamat was a form of deep protest of the village (aul), not an ideology of resistance. The form of active resistance in the republic is presented as mass migrations to China, which was due to the desire to “wait out” unstable times, so rumors about migrations were widely circulated in the borderlands. It is emphasized that rumors were an alternative view of Soviet reality, they slowed down the destruction of the village (aul) as a rural community and ensured the stability of traditional society.