bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Braided Stent With Customized Simulation Software for Treatment of Intracranial Aneurysms: Multicenter Prospective Trial Before Unrestricted Clinical Application
Authors: Kan Issei , Oishi Hidenori , Hyodo Akio , Nemoto Shigeru , Fujimura Soichiro , Ishibashi Toshihiro , Sumita Kazutaka , Takigawa Tomoji , Teranishi Kohsuke , Kodama Tomonobu , Kato Naoki , Takao Hiroyuki , Murayama Yuichi 
Published: October 2023

BACKGROUND AND OBJECTIVES:
Planning/guidance software became important tools for physicians' presurgical optimal decision-making. However, there are no intracranial stent products with specifically associated simulation software. We report the “premarket” clinical trial of a new braided stent with a customized simulation software.

METHODS:
A stent system with 3 mesh density types (16, 24, and 32 wire mesh) was designed based on computational flow dynamics technology, and a simulation software (virtual stent planner [VSP]) was developed for the optimal stent deployment planning. Stents were selected after simulation on preoperative 3D-processed angioimages, and accuracy of the VSP was evaluated.

RESULTS:
Thirty-three unruptured intracranial aneurysms were successfully treated with VSP guidance. Twenty aneurysms (61%) were anterior circulation aneurysms, and 13 (39%) were posterior circulation aneurysms. The average aneurysm size was 7.1 mm, and the mean follow-up period was 19.2 months (11-39.0). There was no major recurrence or retreatment during follow-up, 2 morbidity cases, and no mortality. VSP planning presented slightly smaller stent dimensions compared with postdeployment: 24.2 vs 25.5 mm average, error —1.3 mm, and difference rate—5.46%.

CONCLUSION:
Based on this result, the new stents and software guidance system were approved by the Ministry of Health and Welfare as a combined medical device. VSP provided precise deployment with minimal error compared with actual stent and can contribute to better stent deployment even for less experienced physicians.
Transorbital Exposure of the Internal Carotid Artery: A Detailed Anatomic and Quantitative Roadmap for Safe Successful Surgery
Authors: Corrivetti Francesco , Guizzardi Giulia , Bove Ilaria , Enseñat Joaquim , Prats-Galino Alberto , Solari Domenico , Cavallo Luigi Maria , Iaconetta Giorgio , Di Somma Alberto , de Notaris Matteo 
Published: October 2023

BACKGROUND AND OBJECTIVES:
The superior eyelid endoscopic transorbital approach has rapidly gained popularity among neurosurgeons for its advantages in the treatment, in a minimally invasive fashion, of a large variety of skull base pathologies. In this study, an anatomic description of the internal carotid artery (ICA) is provided to identify risky zones related to lesions that may be approached using this technique. In this framework, a practical roadmap can help the surgeon to avoid potentially life-threatening iatrogenic vascular injuries.

METHODS:
Eight embalmed adult cadaveric specimens (16 sides) injected with a mixture of red latex and iodinate contrast underwent superior eyelid transorbital endoscopic approach, followed by interdural dissection of the cavernous sinus, extradural anterior clinoidectomy, and anterior petrosectomy, to expose the entire “transorbital” pathway of the ICA. Furthermore, the distance of each segment of the ICA explored by means of the superior eyelid endoscopic transorbital approach was quantitatively analyzed using a neuronavigation system.

RESULTS:
We exposed 4 distinct ICA segments and named the anatomic window in which they are displayed in accordance with the cavernous sinus triangles distribution of the middle cranial fossa: (1) clinoidal (Dolenc), (2) infratrochlear (Parkinson), (3) anteromedial (Mullan), and (4) petrous (Kawase). Critical anatomy and key surgical landmarks were defined to further identify the main danger zones during the different steps of the approach.

CONCLUSION:
A detailed knowledge of the reliable surgical landmarks of the course of the ICA as seen through an endoscopic transorbital route and its relationship with the cranial nerves are essential to perform a safe and successful surgery.
Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis
Authors: Mastropasqua Francesca , Oksanen Marika , Soldini Cristina , Alatar Shemim , Arora Abishek , Ballarino Roberto , Molinari Maya , Agostini Federico , Poulet Axel , Watts Michelle , Rabkina Ielyzaveta , Becker Martin , Li Danyang , Anderlid Britt-Marie , Isaksson Johan , Lundin Remnelius Karl , Moslem Mohsen , Jacob Yannick , Falk Anna , Crosetto Nicola , Bienko Magda , Santini Emanuela , Borgkvist Anders , Bölte Sven , Tammimies Kristiina 
Published: October 2023

ABSTRACT
Genetic variants affecting Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) have been identified in several neurodevelopmental disorders (NDDs). HNRNPU is widely expressed in the human brain and shows the highest postnatal expression in the cerebellum. Recent studies have investigated the role of HNRNPU in cerebral cortical development, but the effects of HNRNPU deficiency on cerebellar development remain unknown. Here, we describe the molecular and cellular outcomes of HNRNPU locus deficiency during in vitro neural differentiation of patient-derived and isogenic neuroepithelial stem cells with a hindbrain profile. We demonstrate that HNRNPU deficiency leads to chromatin remodeling of A/B compartments, and transcriptional rewiring, partly by impacting exon inclusion during mRNA processing. Genomic regions affected by the chromatin restructuring and host genes of exon usage differences show a strong enrichment for genes implicated in epilepsies, intellectual disability, and autism. Lastly, we show that at the cellular level HNRNPU downregulation leads to an increased fraction of neural progenitors in the maturing neuronal population. We conclude that the HNRNPU locus is involved in delayed commitment of neural progenitors to differentiate in cell types with hindbrain profile.
Policy analysis on municipal solid waste management in Dhaka South City Corporation, Bangladesh: A qualitative study
Authors: Sultana Tangila , Azim Nafiul , Akuju Faridah , Joarder Taufique 
Published: October 2023

Background: Inadequate and improper municipal solid waste (MSW) management is one of the significant reasons behind the environmental deterioration in Bangladesh. The projected daily waste generation for 2025 in Dhaka City is 47,665 tons, half of which remains uncollected despite door-to-door community-based waste collection. There are few studies on MSW management in Bangladesh, most focusing on household-level waste management, measurement of the amount of MSW, etc., but none applied a political economy lens to examine the policy issues related to MSW management. This study aimed to explore the context, actors, and processes regarding MSW management of policies in Dhaka City, Bangladesh, applying the policy-triangle-framework. Methods: This study adopted an exploratory qualitative approach, and document reviews and key informant interviews were conducted from September 2016 to January 2017. Results: We found that the issue of MSW slowly entered the policy documents starting with the Sixth-Five Year Plan (2011-2015), with some earlier sporadic policy initiatives. Due to its being a relatively new concept, stakeholders still lack the expertise to tackle the issue leading to donor dependence. MSW management demands multi-stakeholder involvement, which, in turn, depends on multi-ministerial and -departmental coordination, which is chronically deficient. MSW policies, like most other social policies, demand citizen involvement, without which both policy formulation processes and their proper implementation are compromised. Conclusion: In order to overcome these policy challenges, the technical and financial capacity of the stakeholders for MSW management should be enhanced, high-level multi-ministerial coordination needs to be strengthened, and citizen empowerment and engagement must be ensured at every step of the MSW policy cycle.
CIViCutils: Matching and downstream processing of clinical annotations from CIViC
Authors: Rosano-Gonzalez María L. , Sreedharan Vipin T. , Hanns Antoine , Stekhoven Daniel J. , Singer Franziska 
Published: October 2023

Background: With the advent of next-generation sequencing, profiling the genetic landscape of tumors entered clinical diagnostics, bringing the resolution of precision oncology to unprecedented levels. However, the wealth of information generated in a sequencing experiment can be difficult to manage, especially if hundreds of mutations need to be interpreted in a clinical context. Dedicated methods and databases are required that assist in interpreting the importance of a mutation for disease progression, prognosis, and with respect to therapy. Here, the CIViC knowledgebase is a valuable curated resource, however, utilizing CIViC in an efficient way for querying a large number of mutations needs sophisticated downstream methods. Methods: To this end, we have developed CIViCutils, a Python package to query, annotate, prioritize, and summarize information from the CIViC database. Our package provides functionality for performing high-throughput searches in CIViC, automatically matching clinical evidence to input variants, evaluating the accuracy of the extracted variant matches, fully exploiting the available disease-specific information according to cancer types of interest, and in-silico predicting drug-target interactions tailored to individual patients. Results: CIViCutils allows the simultaneous query of hundreds of mutations and is able to harmonize input across different nomenclatures. Moreover, it supports gene expression data, single nucleotide mutations, as well as copy number alterations as input. We utilized CIViCutils in a study on the bladder cancer cohort from The Cancer Genome Atlas (TCGA-BLCA), where it helped to extract clinically relevant mutations for personalized therapy recommendation. Conclusions: CIViCutils is an easy-to-use Python package that can be integrated into workflows for profiling the genetic landscape of tumor samples. It streamlines interpreting large numbers of variants with retrieving and processing curated CIViC information.
Efficacy of scapular and upper limb proprioceptive neuromuscular facilitation techniques on scapular alignment, upper limb function, and gait in subacute stroke: a randomized controlled trial protocol
Authors: Saklecha Akshaya , Quershi Moh’d Irshad , Raghuveer Raghumahanti , Harjpal Pallavi 
Published: October 2023

Background: Stroke is a neurological disability produced by vascular-related acute focal injury to the central nervous system and is one of the leading causes of disability in adults, and it is frequently accompanied by motor skill loss. Patients suffering from hemiplegia after a stroke are more prone to have fall and are more likely to experience further injury due to irregular gait, diminished muscular strength, and functional impairment. In the affected upper limb of the hemiplegic stroke, spasticity in the shoulder girdle causes scapular malalignment, which reduces the functional mobility and stability of the upper limb. This is reflected as the reduced reciprocal arm swing during walking, which is further reinforced by an abnormal synergy pattern on the affected side. Proprioceptive neuromuscular facilitation (PNF) is a treatment strategy that stimulates motor activity and enhances control and function of the neuromuscular system. This research protocol is intended to assess and evaluate the effects of applying scapular and upper limb PNF along with conventional physiotherapy treatment to subacute-stroke patients on their scapular alignment, upper limb function, and gait. Methods: A total of 40 individuals in total will be allocated equally into two groups, group-A (experimental) and group-B (control). Both groups will be receiving treatment for six weeks with five sessions per week. Each patient will be examined both before and after therapy using the Palpation Meter (PALM), the Fugl-Meyer Assessment of Upper Extremity (FMA-UE), 10-Meter Walk Test, Handheld dynamometer (10MWT), and Dynamic gait index (DGI). After six weeks of therapy, the results will be assessed and the data will be analyzed before and after the intervention using a paired t-test to discover within-group differences in measurements. Conclusions: This physiotherapy method may be used in the management of stroke patients if our study's hypothesis is found to be valid. Registration: CTRI (CTRI/2023/05/052930, 19/05/2023).
Developing a core outcome set (COS) for Dementia with Lewy bodies (DLB)
Authors: Grycuk Emilia , Eichenholtz Emily , Aarsland Dag , Betzhold Sara , Daly Gillian , Fitzpatrick Rachel , Folkerts Ann-Kristin , Kalbe Elke , Kane Joseph PM , Kinchin Irina , Saldanha Ian J , Smith Valerie , Taylor John-Paul , Thompson Rachel , Leroi Iracema 
Published: October 2023

Background: Dementia with Lewy bodies (DLB) is an important cause of dementia with a range of clinical manifestations, including motor, neuropsychiatric, and autonomic symptoms. Compared with more common forms of dementia such as Alzheimer’s disease, DLB has been the focus of significantly fewer treatment studies, often with diverse outcome measures, making comparison and clinical implementation difficult. A core outcome set (COS) can address this by ensuring that data are comparable, relevant, useful, and usable for making the best healthcare decisions. Methods: Using a multi-stage approach, development of the DLB-COS will include the following stages: (1) A systematic review, following PRISMA guidelines to create an initial long list of outcomes; (2) A two-round online Delphi including clinicians, scientists, policymakers, and individuals with lived experience of DLB and their representatives; (3) An online consensus meeting to agree on the final core list of outcomes (the final DLB-COS) for use in research and clinical practice; (4) A literature search to identify appropriate measurement instruments for the DLB-COS outcomes; (5) A final consensus meeting of the professional stakeholders who attended the online consensus meeting to agree on the instruments that should be used to measure the outcomes in the DLB-COS; and (6) Global dissemination. Discussion: This is a multi-stage project to develop a COS to be used in treatment trials for DLB. A DLB-COS will ensure the selection of relevant outcomes and will identify the instruments to be used to measure DLB globally.
Communication partner training for student health and social care professionals engaging with people with stroke acquired communication difficulties: A realist review.
Authors: Fitzmaurice Yvonne , Beeke Suzanne , Isaksen Jytte , Cunningham Una , Jagoe Caroline , Shé Éidín Ní , McMenamin Ruth 
Published: October 2023

Background: Stroke acquired communication impairments impede effective communication. Consequently, in stroke care, communicative interactions can be challenging for both patients and staff and can predispose patients to increased risk of preventable adverse events. Communication partner training (CPT) can mitigate such negative outcomes by optimising communicative interactions. Providing CPT to student health and social care professionals (SH&SCPs) has the potential to enhance their clinical expertise and experiences and enhance the future clinical care of patients with stroke acquired communication impairments. This research aims to expand our understanding of how CPT is operationalised for SH&SCPs in higher education institutions and determine: what works; for whom; in what contexts; how and why? Methods: This review is phase 1 of a research project employing a realist approach with public and patient involvement (PPI). It incorporates five iterative steps: 1.) Clarifying the scope; 2.) Searching for evidence; 3.) Selecting and appraising evidence; 4.) Data extraction; 5.) Synthesising data and developing a middle range theory explaining how CPT is expected to work for SH&SCPs. An advisory group, including PPI advisors, content experts, SH&SCPs and realist experts has been set up to consult throughout the review and collaboratively agree the middle range theory. Discussion: While there is an evolving evidence base for CPT, including stroke specific CPT for SH&SCPs, it is acknowledged that there are challenges to its implementation in complex real-world settings. In combining empirical evidence with theoretical understanding, realist review permits synthesis of data from diverse sources and goes beyond determining efficacy to explore generative causation and solutions for real world practice. A middle range realist programme theory that coherently explains how CPT is expected to work when teaching SH&SCPs to communicate with people with stroke acquired communication impairments will provide educators with new insights into CPT development and implementation in their higher education institutions.
The effect of mathematics self-beliefs on mathematics achievement: the case of undergraduate university students in Ethiopia
Authors: Woldemichael Belay , Semela Tesfaye , Tulu Abrham 
Published: October 2023

Background: This study aimed at exploring the influence of mathematics self-beliefs on mathematics achievement. Methods: Data was obtained on a random sample of 400 undergraduate students (M=245 and F=155) from three Ethiopian public Universities by using self-reported questionnaire. The instrument, which was adapted from Butler (2016), consists of measures of self-beliefs, expectancy-value, and achievement goal-related motivation. In addition, a 25-item Mathematics Achievement Test (MAT) was developed and validated to measure mathematics achievement. The internal consistency reliability of the MAT was found to be high (alpha =0.84). Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM) were employed to assess systematic relationship between math self-beliefs and math achievement. Results: Results reveal that mathematics self-beliefs have a significant influence on mathematics achievement, whereas expectancy-value and achievement goal have no significant influence on mathematics achievement. Conclusions: Finally, the study outlines the implications for teaching and learning, and research.
METHODOLOGICAL APPROACHES TO MOTIVATION AND STIMULATION OF THE PROJECT TEAM
Authors: Mitrofanova Aleksandra , Brikoshina Irina 
Published: October 2023

The article substantiates the relevance of the issues of motivation and stimulation of the activities of project team members, due to the high significance of motivation and involvement of project team members from the point of view of achieving the final results of project activities. The staff is one of the most important resources of the team, because only the presence of employees with the necessary professional and personal qualities, united by common values, will ensure effective teamwork to achieve the goals of the team. The article examines the specifics of the motivation of project team members, considers the possibilities and limitations of using well-known motivational theories to motivate the project team; systematizes typical mistakes of project managers when motivating team members and ways to overcome them; offers recommendations for increasing the motivation of project team members; it is shown that the complex and multidimensional motivation of project team members necessitates the use of a full range of directions and methods of stimulating their activities, including material (monetary and non-monetary) and non-material incentives.
Reflective dual field-of-view optical system based on the Alvarez principle
Authors: Zettlitzer Lucas , Gross Herbert , Risse Stefan , Theska René 
Published: October 2023

A novel, to the best of our knowledge, dual-state reflective optical
relay system based on the Alvarez system is proposed, which can be
used for remote sensing applications. By keeping the image and pupil
positions constant, it can be combined with a telescope to achieve two
different magnifications. As a compact structure with only two moving
parts, freeform optical mirrors and a nearly diffraction limited
performance for the infrared wavelength 8 µm make it an attractive
subsystem for space applications. Different design tradeoffs and the
preferred layout properties are discussed in detail.
Dual-mode distributed feedback quantum cascade laser based on stacked 3D monolithic integration for on-chip multi-channel gas sensing
Authors: Lu Xiyu , Guan Yanjiao , Yang Pengchang , Niu Shan , Ma Yu , Wang Lijun , Zhuo Ning , Zhang Jinchuan , Zhai Shenqiang , Cheng Fengmin , Liu Shuman , Liu Fengqi , Liu Junqi 
Published: October 2023

To facilitate the development of on-chip integrated mid-infrared multi-channel gas sensing systems, we propose a high-power dual-mode (7.01 and 7.5 μm) distributed feedback quantum cascade laser based on stacked 3D monolithic integration. Longitudinal mode control is achieved by preparing longitudinal nested bi-periodic compound one-dimensional Bragg gratings along the direction of the cavity length in the confinement layer. Additionally, transverse coherent coupling ridges perpendicular to the cavity length direction are fabricated in the upper waveguide layer to promote the fundamental transverse mode output when all ridges are in phase. Stable dual-wavelength simultaneous emission with a side-mode suppression ratio of more than 20 dB was achieved by holographic exposure and wet etching. The entire spectral tuning range covers nearly 100 nm through joint tuning of the injection current and heat-sink temperature. High peak power and beam quality are guaranteed by the parallel coherent integration of seven-element ridge arrays. The device operates in a fundamental supermode with a single-lobed far-field pattern, and its peak output power reaches 3.36 W in pulsed mode at 20°C. This dual-mode laser chip has the potential for in-situ on-chip simultaneous detection of CH4 and C2H6 gases in leak monitoring.
High performance visible generation of Ho3+-doped all-fiber lasers
Authors: Ji Shuaihao , Lin Xuexian , Xiao Bo , Wang Zhongyu , Lin Xiuji , Cai Zhiping 
Published: October 2023

Direct generation of visible frequency from a compact all-fiber laser while preserving high output characteristics has been a subject of research in laser technology. We investigated the high output performance of all-fiber lasers based on Ho3+-doped ZBLAN fluoride glass fiber especially operating in the deep-red band by pumping at 640 nm. Remarkably, we achieved a maximum continuous-wave output power of 271 mW at 750 nm with a slope efficiency of 45.1%, which represents, to our knowledge, the highest direct output power recorded in an all-fiber laser with a core diameter of less than 10 μm in the deep-red band. Additionally, we successfully developed a 1.2 μm all-fiber laser pumped by a 640 nm laser. We extensively investigated the correlation between these two-laser generation processes and their performances at 750 nm and 1.2 μm wavelengths. By increasing the pumping rate, we observed an efficient recycling of population through a highly excited state absorption process, which effectively returned the population to the upper laser level of the deep-red transition. Moreover, we determined the optimized conditions for such lasers, identified the processes responsible for populating the excited state energy levels, and established the corresponding spectroscopic parameters.