bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different Combinations of the Metabolic Syndrome Criteria and Cardiovascular Disease
Authors: Lind Lars 
Published: October 2023

ABSTRACTBackgroundThe metabolic syndrome (MetS) has previously been linked to incident cardiovascular disease (CVD). It is however not known if certain combinations of MetS criteria show a higher risk than others.MethodsWe used data from UK biobank in which 388,800 individuals had data on MetS using the five harmonized NCEP criteria. The cohort was followed for a median of 12.6 years. A composite CVD outcome was used (myocardial infarction, ischemic stroke or heart failure).ResultsThe risk of incident CVD (n= 22,572) increased in a fairly linear fashion with increasing number of MetS criteria. In the groups showing three MetS criteria, thus fulfilling the definition of MetS, the highest risk was seen in those with the combination of the glucose + waist circumference + HDL criteria (HR 3.90, 95%CI 3.17-4.80). In the group with four criteria, the highest HRs were seen in the groups not including triglyceride or the blood pressure criteria (HR 3.96, 95%CI 3.57-4.59 and HR 3.79, 95%CI 3.13-4.59, respectively). The risk of CVD in those with all five criteria was in the same order (HR 3.65, 95%CI 3.33-4.01). Mendelian randomization indicated a causal role of MetS for coronary heart disease (CHD) and heart failure, but not ischemic stroke, while use of polygenetic risk scores for CHD and ischemic stroke were related to MetS criteria in a similar fashion as observational data.ConclusionCertain combinations of risk factors in individuals with the metabolic syndrome criteria showed a higher risk of future CVD than others.
Reproducibility of COVID-era infectious disease models
Authors: Henderson Alec S. , Hickson Roslyn I. , Furlong Morgan , McBryde Emma S. , Meehan Michael T. 
Published: October 2023

AbstractInfectious disease modelling has been prominent throughout the COVID-19 pandemic, helping to understand the virus’ transmission dynamics and inform response policies. Given their potential importance and translational impact, we evaluated the computational reproducibility of infectious disease modelling articles from the COVID era. We found that only four out of 100 randomly sampled studies released between January 2020 and August 2022 could be computationally reproduced using the resources provided (e.g., code, data, instructions). For the 100 most highly cited articles from the same period we found that only 11 were reproducible. Reflecting on our experience, we discuss common issues affecting computational reproducibility and how these might be addressed.
Molecular dependencies and genomic consequences of a global DNA damage tolerance defect
Authors: de Groot Daniel , Spanjaard Aldo , Shah Ronak , Kreft Maaike , Morris Ben , Lieftink Cor , Catsman Joyce J.I. , Ormel Shirley , Ayidah Matilda , Pilzecker Bas , Buoninfante Olimpia Alessandra , van den Berk Paul C.M. , Beijersbergen Roderick L. , Jacobs Heinz 
Published: October 2023

ABSTRACTDNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. To determine the molecular and genomic impact of a global DDT defect, we studiedPcnaK164R/-;Rev1-/-compound mutants. Double mutant (DM) cells displayed increased replication stress, hypersensitivity to genotoxic agents, replication speed, and repriming. A whole genome CRISPR-Cas9 screen revealed a strict reliance of DM cells on the CST complex, where CST promotes fork stability. Whole genome sequencing indicated that this DM DDT defect favors the generation of large, replication-stress inducible deletions of 0.4-4.0kbp, defined as type 3 deletions. Junction break sites of these deletions revealed preferential microhomology preferences of 1-2 base pairs, differing from the smaller type 1 and type 2 deletions. These differential characteristics suggest the existence of molecularly distinct deletion pathways. Type 3 deletions are abundant in human tumors, can dominate the deletion landscape and are associated with DNA damage response status and treatment modality. Our data highlight the essential contribution of the DDT system to genome maintenance and type 3 deletions as mutational signature of replication stress. The unique characteristics of type 3 deletions implicate the existence of a novel deletion pathway in mice and humans that is counteracted by DDT.
Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control
Authors: Mouery Ryan D , Hsu Carolyn , Bonacci Thomas , Bolhuis Derek L , Wang Xianxi , Mills Christine A , Toomer E Drew , Canterbury Owen G , Robertson Kevin C , Branigan Timothy B , Brown Nicholas G , Herring Laura E , Emanuele Michael J 
Published: October 2023

AbstractTargeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCFβTrCP. However, the magnitude to which PLK1 shapes the mitotic proteome has not been characterized. Combining deep, quantitative proteomics with pharmacologic PLK1 inhibition (PLK1i), we identified more than 200 proteins whose abundances were increased by PLK1i at G2/M. We validate many new PLK1-regulated proteins, including several substrates of the cell cycle E3 SCFCyclinF, demonstrating that PLK1 promotes proteolysis through at least two distinct SCF-family E3 ligases. Further, we found that the protein kinase A anchoring protein AKAP2 is cell cycle regulated and that its mitotic degradation is dependent on the PLK1/βTrCP-signaling axis. Interactome analysis revealed that the strongest interactors of AKAP2 function in signaling networks regulating proliferation, including MAPK, AKT, and Hippo. Altogether, our data demonstrate that PLK1 coordinates a widespread program of protein breakdown at G2/M. We propose that dynamic proteolytic changes mediated by PLK1 integrate proliferative signals with the core cell cycle machinery during cell division. This has potential implications in malignancies where PLK1 is aberrantly regulated.
Identification and characterization of a β-1,4 Galactosidase fromElizabethkingia meningosepticaand its application on living cell surface
Authors: Tong Yongliang , Lu Xinrong , Shen Danfeng , Rao Lin , Zou Lin , Lyu Shaoxian , Hou Linlin , Sun Guiqin , Chen Li 
Published: October 2023

AbstractThe biological function of terminal galactose on glycoprotein is an open field of research. Although progress had being made on enzymes that can remove the terminal galactose on glycoproteins, there is a lack of report on galactosidases that can work directly on living cells. In this study, a unique beta 1,4 galactosidase was isolated fromElizabethkingia meningoseptica(Em). It exhibited favorable stability at various temperatures (4-37℃) and pH (5-8) levels and can remove β-1, 4 linked galactoses directly from glycoproteins. Using Alanine scanning, we found that two acidic residues (Glu-468, and Glu-531) in the predicted active pocket are critical for galactosidase activity. In addition, we also demonstrated that it could cleave galactose residues present on living cell surface. As the enzyme has a potential application for living cell glycan editing, we named it glycan editing galactosidase I or geGalaseI. In summary, our findings lay the groundwork for prospective investigations by presenting a prompt and gentle approach for the removal of galactose moieties from cell surface.
Reading relationally: a proposal for relational-comparative research concerning city/capital of culture events
Authors: Grabher Barbara 
Published: October 2023

PurposeGarcía and Cox (2013) have clarified that there is an urgent need for comparative studies of city/capital of culture (COC) events. With the ambition to foster exchange and learning, knowledge production concerning cultural initiatives requires to think beyond the individual case study of a singular event. Simultaneously, the two scholars observe comparability and context-sensitivity between events as a major issue in these particular canons of research.Design/methodology/approachDrawing upon the research experience of the project, this article experiments with a novel reading of city/capital of culture events.FindingsBeyond the singularity of a case study but with attention to context-sensitivities, the article proposes a relational reading practice to study the culture-led event framework. The author illustrates the proposed approach with material collected in ethnographic fieldwork in the cities of Donostia/San Sebastián, European COC 2016, and Hull, UK COC 2017.Originality/valueBy using one case study as a metaphorical pair of glasses framing the investigative perspective on the other, an analytical relationship between two COC events is established, fostering a broader prism of analysis and connected learning.
Choosing invisibility? Exploring service (dis)engagement of women experiencing multiple disadvantage
Authors: Hess Carolin 
Published: October 2023

Purpose
The shift in policy discourse towards individualism is affecting service provision and access, which has become increasingly conditioned on individual agency and the “deservingness” of the recipient. Gendered and intersectional experiences of homelessness and excluded populations less likely to be living on the streets remain overlooked and unaddressed. This study thus aims to uncover what drives “invisibility” in services for women experiencing multiple disadvantage and the gendered constraints the women are facing when exiting and navigating multiple disadvantage.

Design/methodology/approach
The paper draws on in-depth interviews with women who face severe and multiple disadvantage and their support staff. Data is also gathered through survey data and observations with a wide range of frontline service providers, as well as support notes and numerical progress data recorded by one of the service providers.

Findings
Contradicting the common assumption that people act as rational actors in their interaction with services, the author found that women’s decisions to (dis)engage may be blinded by forces of multiple disadvantage and mistrust. These are often developed as a result of systemic and gendered constraints that limit women’s capabilities and exercise of choice. Barriers in service access often amplified the personal barriers they were facing and reinforced women’s decisions to not engage with services.

Research limitations/implications
The author hopes that this paper sheds light on the particular set of barriers women with multiple disadvantage face, which will be vital to reach women who face severe disadvantage and provide more effective policies, care and support.

Originality/value
This study gives voice to a particular hidden population: women with multiple disadvantage. It contributes to existing frameworks on agency and choice by understanding gendered barriers behind service engagement and how services themselves may be contributing to women’s invisibility.
Applying the Goal, Question, Metric method to derive tailored dynamic cyber risk metrics
Authors: Calvo Miguel , Beltrán Marta 
Published: October 2023

Purpose
This paper aims to propose a new method to derive custom dynamic cyber risk metrics based on the well-known Goal, Question, Metric (GQM) approach. A framework that complements it and makes it much easier to use has been proposed too. Both, the method and the framework, have been validated within two challenging application domains: continuous risk assessment within a smart farm and risk-based adaptive security to reconfigure a Web application firewall.

Design/methodology/approach
The authors have identified a problem and provided motivation. They have developed their theory and engineered a new method and a framework to complement it. They have demonstrated the proposed method and framework work, validating them in two real use cases.

Findings
The GQM method, often applied within the software quality field, is a good basis for proposing a method to define new tailored cyber risk metrics that meet the requirements of current application domains. A comprehensive framework that formalises possible goals and questions translated to potential measurements can greatly facilitate the use of this method.

Originality/value
The proposed method enables the application of the GQM approach to cyber risk measurement. The proposed framework allows new cyber risk metrics to be inferred by choosing between suggested goals and questions and measuring the relevant elements of probability and impact. The authors’ approach demonstrates to be generic and flexible enough to allow very different organisations with heterogeneous requirements to derive tailored metrics useful for their particular risk management processes.
An adaptive dynamic community detection algorithm based on multi-objective evolutionary clustering
Authors: Wang Wenxue , Li Qingxia , Wei Wenhong 
Published: October 2023

PurposeCommunity detection of dynamic networks provides more effective information than static network community detection in the real world. The mainstream method for community detection in dynamic networks is evolutionary clustering, which uses temporal smoothness of community structures to connect snapshots of networks in adjacent time intervals. However, the error accumulation issues limit the effectiveness of evolutionary clustering. While the multi-objective evolutionary approach can solve the issue of fixed settings of the two objective function weight parameters in the evolutionary clustering framework, the traditional multi-objective evolutionary approach lacks self-adaptability.Design/methodology/approachThis paper proposes a community detection algorithm that integrates evolutionary clustering and decomposition-based multi-objective optimization methods. In this approach, a benchmark correction procedure is added to the evolutionary clustering framework to prevent the division results from drifting.FindingsExperimental results demonstrate the superior accuracy of this method compared to similar algorithms in both real and synthetic dynamic datasets.Originality/valueTo enhance the clustering results, adaptive variances and crossover probabilities are designed based on the relative change amounts of the subproblems decomposed by MOEA/D (A Multiobjective Optimization Evolutionary Algorithm based on Decomposition) to dynamically adjust the focus of different evolutionary stages.
Efficiency-oriented training and development based on service process observation and assessment in the workplace
Authors: Zhou Jinquan , He Wenjin 
Published: October 2023

PurposeThis paper aims to establish a service efficiency-oriented framework for training design and evaluation as a pivotal service procedure in the workplace to fill the gap between training and organizational performance in a service context.Design/methodology/approachA semi-structured interview was first employed to confirm the primary indicator for training programs and criteria design as the pivotal factor for operational efficiency. An observation experiment was subsequently conducted to reveal that the training program can be redesigned according to the concrete operation effects and influencing factors for operational efficiency in the workplace.FindingsThe proposed service efficiency-oriented training model is suggested to underline and guide the activities for training requirements, training methods, training criteria and training evaluation for the service sector. Training auditing, analyzing and redesigning based on service efficiency could help to integrate service efficiency so that service organizations can readjust their specific training needs and concise the training program in the human resource management practice.Research limitations/implicationsThis study only conducted an on-site observational experiment on one of the casinos in Macau. An observational method assessed the conceptual model in the context of table game operations. More quantitative approaches like AI-assisted systems may be employed in the future. The representativeness of the sample is somewhat limited. In addition, the service efficiency-oriented training concept model is an open system that any organization could extend by incorporating more elements in each part that can be developed to meet their human resource management needs. Finally, other service-oriented organizations like airlines and banks can learn from the theoretical model proposed in this article. It is suggested that non-profit organizations would be a better research area.Practical implicationsThe finding can provide organizations and practitioners with insights and tools on how to provide and evaluate service efficiency and assess employee performance.Social implicationsThe proposed service efficiency-oriented training model provides a theoretical foundation for training and organizational performance for service organizations.Originality/valueThis study is the first to develop a service efficiency-oriented training framework with training needs, methods, criteria and evaluation. A service industry sample was used to verify the framework in the context of casino game pace and dealer training for table games. Suggestions for a combination of management are provided for casino operators to redesign and evaluate the dealer training program for service improvement.
Appraising institutional management of urban water supply in Ghana: the role of the stakeholders
Authors: Aigbavboa Clinton Ohis , Addo Lawrence Yao , Ebekozien Andrew , Thwala Wellington Didibhuku , Arthur-Aidoo Bernard Martins 
Published: October 2023

Purpose
Access to clean drinking water is a major encumbrance in developing countries. In Ghana, urban water supply is below internationally recognised standards, especially among the urban poor, sub-urban and rural communities. Stakeholders and institutional inefficiencies may be hindrances facing the Ghanaian water supply process. Therefore, this study aims to appraise the motivational factors and outcome of stakeholders’ engagement and identify the factors that influence effective institutional management of urban water supply in Ghana.

Design/methodology/approach
Sequential exploratory mixed methods were adopted and analysed to proffer answers to the research questions. Nineteen participants and 521 respondents were sampled for the qualitative and quantitative phases.

Findings
Findings reveal that the institutional processes and stakeholder engagement significantly influence the effectiveness of the management of urban water supply in Ghana. Findings identified 35 motivational factors and categorised them into the health of the population, socio-economic, technological and innovation trends, policy reform and adaptive governance. Also, the 22 institutional factors identified were categorised into three groups: regulatory framework, ethics for managing water supply and the culture of managing water supply.

Originality/value
Besides the study addressing the theoretical gap regarding which variables are germane in influencing the effective management of urban water supply, the study may be among the top studies that have appraised the role of stakeholders in the institutional management of urban water supply in Ghana.
The function of food refusal in male prisons and custodial environments. A rapid evidence assessment (REA)
Authors: Adlam Jessica , Powell Gemma 
Published: October 2023

Purpose
This rapid evidence assessment (REA) study aims to synthesise what is known about food refusal within male prison populations to aid a better understanding of why this occurs. By looking at the various functions of food refusal for this population, it is hoped that professionals can better support prisoners’ needs in this area.

Design/methodology/approach
A rapid review of available data within the published literature was completed. Searches were conducted on two databases (PsychInfo and MedLine), and a total of 328 articles were screened using a three-stage process. This resulted in 13 articles being identified for the final sample, which were reviewed and synthesised into themes by looking for commonalities.

Findings
Five themes were identified: “to protest”, “to achieve goals or demands”, “to manage interpersonal difficulties with prison/custodial staff”, “to end life” and “mental health and personality disorder”. The findings appear to suggest that food refusal in this context may be predominantly driven by a need to communicate or gain control.

Practical implications
To help prevent and cease food refusal, it will be beneficial for prison staff to use approaches that support prisoners feeling a sense of fairness, transparency, control and autonomy, as well as problem-solving skills and establishing a sense of purpose and motivation.

Originality/value
This REA confirmed there is a lack of good-quality research into the functions of food refusal among prisoners in the UK. Future research should involve contact with prisoners who have engaged in food refusal to understand motivations firsthand.
Intellectual capital and bank’s performance: a cross-national approach
Authors: Chinnasamy Gopalakrishnan , Madbouly Araby , Vinoth S. , Chandran Preetha 
Published: October 2023

Purpose
This study aims to identify the impact of intellectual capital (IC) on the bank’s performance using a cross-country approach with India and Gulf Cooperation Council (GCC) countries using the Skandia navigator model (SNM).

Design/methodology/approach
This study uses a mixed-methods research approach by taking financial and non-financial measures to assess the impact of the IC on the bank’s performance using the SNM. The study implies an analysis of the data from the top ten banks in India and twenty banks in GCC countries. The selection was done based on the volume of the bank’s business for three years (2019–2020, 2020–2021 and 2021–2022).

Findings
The research has three main findings: there is a positive impact of IC on the bank’s performance; amongst the factors of SNM, there is a direct impact of human capital and customer focus on the performance of the selected banks in both India and GCC countries; and the other factors of SNM such as structural capital and process focus, renewal and development focus also affect the selected banks.

Research limitations/implications
The outcomes of the research may be useful for policymakers in India and GCC countries, as it identifies IC components that have a significant impact on the bank’s performance. This might enable them to develop policies that foster such factors, which, consequently, will improve the performance of the banks in the selected countries.

Originality/value
This study is an attempt to fill the gap in the existing literature on IC and bank’s performance for two different types of countries using the SNM.