bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionalization of dental implant surfaces using adhesion molecules
Authors: Schliephake H. , Scharnweber D. , Dard M. , Sewing A. , Aref A. , Roessler S. 
Published: December 2004

AbstractThe aim of the present study was to test the hypothesis that organic coating of titanium screw implants that provides binding sites for integrin receptors can enhance periimplant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Four types of implants were evaluated in each animal: (1) implants with machined titanium surface, (2) implants coated with collagen I, (3) implants with collagen I and cyclic RGD peptide coating (Arg‐Gly‐Asp) with low RGD concentrations (100 μmol/mL), and (4) implants with collagen I and RGD coating with high RGD concentrations (1000 μmol/mL). Periimplant bone regeneration was assessed histomorphometrically after 1 and 3 months in five dogs each by measuring bone implant contact (BIC) and the volume density of the newly formed periimplant bone (BVD). After 1 month, BIC was significantly enhanced only in the group of implants coated with the higher concentration of RGD peptides (p = 0.026). Volume density of the newly formed periimplant bone was significantly higher in all implants with organic coating. No significant difference was found between collagen coating and RGD coatings. After 3 months, BIC was significantly higher in all implants with organic coating than in implants with machined surfaces. Periimplant BVD was significantly increased in all coated implants in comparison to machined surfaces also. It was concluded that organic coating of machined screw implant surfaces providing binding sites for integrin receptors can enhance bone implant contact and periimplant bone formation. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 73B: 88–96, 2005
Strategies for building and communicating trust in electronic banking: A field experiment
Authors: Yousafzai Shumaila Y. , Pallister John. G. , Foxall Gordon R. 
Published: December 2004

AbstractThe strong association between the high levels of trust and the banking sector has not yet been translated in the electronic world to its full potential. For the future growth of e‐banking the issues of security and privacy must be removed. In an experimental setting, this study examines the effectiveness of potential trust‐building strategies for e‐banking and their impact on on‐line customers' perceptions of trustworthiness of the bank, by specifically focusing on the information clues presented on the bank's Web site. Structural assurance and situational normality mechanisms both had an impact on customers' trustworthiness perceptions, suggesting that banks need to use a portfolio of strategies to build the customer's trust. The results further suggest that communication of meaningful and timely information has the potential to influence customers' trusting intentions. © 2005 Wiley Periodicals, Inc.
Curing kinetics and reaction‐induced homogeneity in networks of poly(4‐vinyl phenol) and diglycidylether epoxide cured with amine
Authors: Su Chean Cheng , Woo E.M. , Huang Yin Ping 
Published: December 2004

AbstractMixtures of diglycidyl ether of bisphenol‐A (DGEBA) epoxy resin with poly(4‐vinyl phenol) (PVPh) of various compositions were examined with a differential scanning calorimeter (DSC), using the curing agent 4,4′‐diaminodiphenylsulfone (DDS). The phase morphology of the cured epoxy blends and their curing mechanisms depended on the reactive additive, PVPh. Cured epoxy/PVPh blends exhibited network homogeneity based on a single glass transition temperature (Tg) over the whole composition range. Additionally, the morphology of these cured PVPh/epoxy blends exhibited a homogeneous network when observed by optical microscopy. Furthermore, the DDS‐cure of the epoxy blends with PVPh exhibited an autocatalytic mechanism. This was similar to the neat epoxy system, but the reaction rate of the epoxy/polymer blends exceeded that of neat epoxy. These results are mainly attributable to the chemical reactions between the epoxy and PVPh, and the regular reactions between DDS and epoxy. Polym. Eng. Sci. 45:1–10, 2005. © 2004 Society of Plastics Engineers.
Model structure analysis through graph theory: partition heuristics and feedback structure decomposition
Authors: Oliva Rogelio 
Published: December 2004

AbstractThe argument of this article is that it is possible to focus on the structural complexity of system dynamics models to design a partition strategy that maximizes the test points between the model and the real world, and a calibration sequence that permits an incremental development of model conﬁdence. It further argues that graph theory could be used as a basis for making sense of the structural complexity of system dynamics models, and that this structure could be used as a basis for more formal analysis of dynamic complexity. After reviewing the graph representation of system structure, the article presents the rationale and algorithms for model partitions based on data availability and structural characteristics. Special attention is given to the decomposition of cycle partitions that contain all the model's feedback loops, and a unique and granular representation of feedback complexity is derived. The article concludes by identifying future research avenues in this arena. Copyright © 2004 John Wiley & Sons, Ltd.
Potential antidepressant LY 367265 presynaptically inhibits the release of glutamate in rat cerebral cortex
Authors: Wang Su‐Jane 
Published: December 2004

AbstractAbnormality of glutamate, one of the excitatory neurotransmitters, has been implicated in psychiatric disorders such as depression. In this study, the effect of the potential antidepressant LY 367265, an inhibitor of the 5‐hydroxytryptamine (5‐HT) transporter and 5‐HT2A receptor antagonist, on the release of endogenous glutamate was investigated in nerve terminals purified from rat cerebral cortex using an on‐line enzyme‐coupled fluorimetric assay. LY 367265 inhibited the release of glutamate evoked by 4‐aminopyridine (4AP) in a concentration‐dependent manner; no effect was seen on KCl‐evoked glutamate release. Examination of the effect of LY 367265 on cytosolic [Ca2+] revealed that the attenuation of glutamate release could be attributed to a reduction in Ca2+ influx. The inhibition of Ca2+ influx by LY 367265 was most likely due to it decreasing synaptosomal excitability because LY 367265 significantly reduced the 4AP‐evoked depolarization of the synaptosomal plasma membrane potential. Glutamate release induced by the Ca2+ ionophore ionomycin was not affected by LY 367265, indicating that LY 367265‐mediated inhibition of glutamate release is not a direct interference in the release process at some point subsequent to Ca2+ influx. Together, these results suggest that LY 367265 effects a decrease in the nerve terminal excitability, which subsequent attenuates the Ca2+ entry through voltage‐dependent Ca2+ channels to cause a decrease in evoked glutamate release. Additionally, compared with the clinically effective antidepressant fluoxetine, a selective serotonin reuptake inhibitor, LY 367265 seems to have a more potent inhibition on 4AP‐evoked glutamate release. Furthermore, the finding that LY 367265 and fluoxetine responses were additive suggests that the simultaneous blockade of 5‐HT2A receptors and 5‐HT uptake transporters might have greater therapeutic efficacy than either action alone. Synapse 55:156–163, 2005. © 2004 Wiley‐Liss, Inc.
Are identity styles important for psychological well‐being?
Authors: Vleioras Georgios , Bosma Harke A. 
Published: December 2004

AbstractA successful identity formation is related to being psychologically well (Erikson, 1963). This link seems to be lost in the identity style literature that focuses either on the maturity of the identity styles, or on adaptive and maladaptive behaviour correlates of identity styles. In this study, we address this lost link. We administered the Identity Style Inventory (Berzonsky, 1992a) and the scales of Psychological Well‐Being (Ryff, 1989) to 230 Hellene (Greek) University students. The Hellenic (Greek) translations of the scales functioned appropriately. The findings suggest that avoiding facing identity issues is negatively related to psychological well‐being, while, when such issues are faced, the way of facing them is not important.
PCDM: a decision support modeling methodology for supply chain, product and process design decisions
Authors: Blackhurst Jennifer , Wu Tong , O’Grady Peter 
Published: December 2004

AbstractWhile there is considerable pressure to improve the operation of supply chains, their inherent complexity can make modeling a supply chain a difficult task. This difficulty is compounded when the need to model the effects of product and process design changes are also considered. Yet there could be considerable benefits in designing supply chains taking into account the operation of the supply chain as well as the design of the product and the design of the manufacturing processes used in the supply chain. This paper aims to address the central research issue of developing a methodology that can assist a manager in making decisions by modeling both the operation of a supply chain design and the effects of product and process design decisions. The proposed methodology, called Product Chain Decision Model (PCDM), is presented in this paper. This uses an abstracted network to model supply chain systems. Finally, an industry example of joint supply chain and product design is described to illustrate the application of PCDM.
The influence of power driven buyer/seller relationships on supply chain satisfaction
Authors: Benton W.C. , Maloni Michael 
Published: December 2004

AbstractResearch on supplier satisfaction in buyer–supplier relationships has been primarily conceptual. One purpose of the research described in this paper is to empirically test the influences of supply chain power on supplier satisfaction. Exploration of the effects of power on factors of supplier satisfaction will provide the key to understanding the power‐satisfaction link in supply chain relationships. This paper shows how the buyer–seller relationship affects supplier satisfaction. In doing so, previous satisfaction and power literature is pulled together to demonstrate that the power‐satisfaction variable must be included in any examination of supply chain partnerships. The three primary objectives of this research are to establish how the different “bases of power” affect the satisfaction of selling firms, investigate how power driven relationships affect supplier satisfaction, and measure the effect of power influences on supplier satisfaction in the automobile industry. Each of these research objectives was achieved. This study establishes the first empirical evidence for the measurement of power‐driven supplier satisfaction. In each of the nine models studied, the power‐affected buyer–supplier relationship was found to have a significant positive effect on both performance and satisfaction. The paths between performance and satisfaction, however, were consistently found to be non‐significant.
Coordinating product design, process design, and supply chain design decisions
Authors: Forza C. , Salvador F. , Rungtusanatham M. 
Published: December 2004

AbstractComplementing Part A which appeared in an earlier issue, Coordinating product design, process design, and supply chain design decisions. Part B. coordinating approaches, tradeoffs, and future research directions introduces four additional papers that belong to this special issue. These four papers seek to provide answers to the following two questions: “What mechanisms allow product design, manufacturing process design, and supply chain design decisions to be coordinated?” and “Why should decisions with respect to product design, manufacturing process design, and supply chain design be coordinated?” Each of the four papers compiled in Part B provides, foremost, an approach to coordinate decisions across the domains of product design, manufacturing process design, and supply chain design. The proposed coordinating mechanisms range from a network‐based modeling approach to an assessment procedure for evaluating product architectures to the integration of relevant suppliers into the new product development (NPD) process to a goal programming modeling approach. The fourth paper in Part B, in fact, deploys the proposed goal programming modeling approach to identify and formalize the potential tradeoffs among decisions across the three domains. Part B completes the special issue by identifying future research opportunities, beyond those highlighted within the seven papers that form Part A and Part B of this special issue on Coordinating product design, process design, and supply chain design decisions.
Build‐to‐order and just‐in‐time as predictors of applied supply chain knowledge and market performance
Authors: Christensen William J. , Germain Richard , Birou Laura 
Published: December 2004

AbstractThe research increases our understanding of a build‐to‐order supply chain (BOSC) by examining the effects of two distinct yet related strategies on applied supply chain knowledge and market performance: a build‐to‐order (BTO) and a just‐in‐time (JIT) strategy. The results show that a BTO strategy positively affects market performance through its influence on the application of supply chain knowledge downstream with customers. Although a JIT strategy does affect the upstream application of knowledge with suppliers, the latter does not predict market performance. Theoretical and managerial implications are presented.
Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone
Authors: Katsube Kosuke , Bishop Allen T. , Simari Robert D. , Ylä‐Herttuala Seppo , Friedrich Patricia F. 
Published: December 2004

AbstractAvascular necrosis of bone is a relatively common clinical condition caused by inflammatory conditions, steroid or other drug use, and trauma that affect many different sites in man. Revascularization of the necrotic bone is slow to occur, often resulting in bone resorption and eventual collapse of the involved bone. Rapid revascularization and subsequent bone remodeling may lead to improved outcomes.Surgical revascularization with arterovenous bundles (AV bundles) or vascularized bone grafts results in neoangiogenesis and bone remodeling. Gene transfer of an angiogenic factor to the vessel wall may be an additional strategy to further accelerate this process. In this study, we examined the effectiveness of vascular endothelial growth factor (VEGF) gene transfer to augment surgical revascularization of necrotic bone. An adenoviral vector, either with the VEGF gene (VEGF‐A) or identical virus without the cDNA VEGF insert (ADV‐ΔE1) was used to transduce endothelial cells in rabbit saphenous arteries. The artery was then placed with its venae comitantes as an AV bundle into necrotic iliac crest bone in vivo. Angiogenesis in the necrotic bone was quantified by bone blood flow measurement and assessment of vessel density following microangiography. The extent of neoangiogenesis was significantly greater in the VEGF group than the control group at 1 week postoperatively. © 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.
Rat supraspinatus muscle atrophy after tendon detachment
Authors: Barton Elisabeth R. , Gimbel Jonathan A. , Williams Gerald R. , Soslowsky Louis J. 
Published: December 2004

AbstractRotator cuff tears are one of the most common tendon disorders found in the healthy population. Tendon tears not only affect the biomechanical properties of the tendon, but can also lead to debilitation of the muscles attached to the damaged tendons. The changes that occur in the muscle after tendon detachment are not well understood. A rat rotator cuff model was utilized to determine the time course of changes that occur in the supraspinatus muscle after tendon detachment. It was hypothesized that the lack of load on the supraspinatus muscle would cause a significant decrease in muscle mass and a conversion of muscle fiber properties toward those of fast fiber types. Tendons were detached at the insertion on the humerus without repair. Muscle mass, morphology and fiber properties were measured at one, two, four, eight, and 16 weeks after detachment. Tendon detachment resulted in a rapid loss of muscle mass, an increase in the proportion of fast muscle fibers, and an increase in the fibrotic content of the muscle bed, concomitant with the appearance of adhesions of the tendon to surrounding surfaces. At 16 weeks post‐detachment, muscle mass and the fiber properties in the deep muscle layers returned to normal levels. However, the fiber shifts observed in the superficial layers persisted throughout the experiment. These results suggest that load returned to the muscle via adhesions to surrounding surfaces, which may be sufficient to reverse changes in muscle mass. © 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.
CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells
Authors: CAO Weiping , LEE Szu Hee , LU Jinhua 
Published: December 2004

Human DCs (dendritic cells) express surface CD83 upon activation. Comparing the surface induction of CD83 with the upregulation of CD40, CD80 and CD86 during LPS (lipopolysaccharide)-induced DC maturation showed that CD83 induction occurred more rapidly. Despite the lack of CD83 on immature DCs, it was detected in these cells by Western blotting and flow cytometry. Indirect immunofluorescence revealed CD83 inside immature DCs in perinuclear regions. CD83 was absent on monocytes and macrophages, but it was detected inside these cells and found to be rapidly surface-expressed upon LPS-induced activation. Whereas CD83 expression on activated DCs was sustainable, its expression on monocytes and macrophages was transient. Optimal interleukin-4 co-stimulation during DC generation from monocytes was found to be essential for stable CD83 surface expression. CD83 was detected as 37 and 50 kDa forms in transfected 293T cells. Macrophages and immature DCs expressed the 37 kDa form, whereas mature DCs predominantly expressed the 50 kDa form. In monocytes, CD83 was detected as a 22 kDa detergent-insoluble form. The rapid CD83 surface induction on DCs and macrophages was blocked by brefeldin A, but not by cycloheximide, showing that fresh CD83 synthesis was not essential. Tunicamycin inhibited the expression of the 50 and 37 kDa CD83 forms, and also blocked CD83 surface expression on DCs and macrophages. PNGase F (peptide N-glycosidase F) digestion reduced the 37 and 50 kDa CD83 forms to 28 kDa. In summary, monocytes, macrophages and immature DCs contain preformed intracellular CD83, and its rapid surface expression upon activation is post-translationally regulated in a process involving glycosylation.
Transgenic expression of human complement regulators reduces skeletal muscle ischaemia/reperfusion injury in mice
Authors: KNIGHT Kenneth R. , SHINKEL Trixie A. , COWAN Peter J. , ROMEO-MEEUW Rosalind , d'APICE Anthony J. F. , MORRISON Wayne A. 
Published: December 2004

This study aimed to explore the hypothesis that activated complement components contribute significantly to I/R (ischaemia/reperfusion) injury in skeletal muscle. After 50, 70 and 90 min of tourniquet ischaemia and 24 h of reperfusion, viability of the medial gastrocnemius muscle in CBA-C57BL/6 wild-type mice, assessed histochemically by reduction of NBT (Nitro Blue Tetrazolium) dye, was 60, 21 and 8% respectively. Skeletal muscle viability after 70 min of ischaemia and 24 h of reperfusion in transgenic mice expressing a combination of human CD46, CD55 and CD59, all inhibitors of complement activation, was 45% compared with 24% in ischaemic reperfused wild-type mice (P=0.008; n=6 per group). Muscle from sham-treated transgenic mice and wild-type littermates had no significant loss of viability relative to normal contralateral gastrocnemius muscle. A significant reduction in myeloperoxidase activity (a measure of neutrophil infiltration), xanthine oxidase activity (a source of free radicals) and water content (a measure of oedema) was observed in ischaemic reperfused muscle from transgenic mice compared with ischaemic reperfused wild-type muscle (P&lt;0.05). Haematoxylin and eosin-stained histological sections also showed less damage and less apparent leucocyte infiltration in muscles from ischaemic reperfused transgenic mice than those from wild-type animals given the same degree of injury. Muscles from sham-treated transgenic and wild-type controls were almost identical with normal muscle. It is concluded that complement activation contributes to the pathogenesis of I/R injury in murine skeletal muscle, resulting in increased neutrophil infiltration into the injured muscle, increased free radical production and vascular permeability during reperfusion, and a net detrimental effect on muscle viability.
Organic anions and potassium salts in nutrition and metabolism
Authors: Demigné Christian , Sabboh Houda , Puel Caroline , Rémésy Christian , Coxam Véronique 
Published: December 2004

AbstractThe present review examines the importance of dietary organic anions in preventive nutrition. Organic anions are chiefly supplied by plant foods, as partially neutralised K salts such as potassium citrate, potassium malate and, to a lesser extent, oxalate or tartrate salts. Animal products may also supply K anions, essentially as phosphate, but also as lactate as a result of fermentative or maturation processes, but these K salts have little alkalinising significance. Citrate and malate anions are absorbed in the upper digestive tract, while a substantial proportion is probably metabolised in the splanchnic area. Whatever their site of metabolism, these anions finally yield KHCO3which is used by the kidneys to neutralise fixed acidity. This acidity essentially reflects the oxidation of excess S amino acids to sulfate ions, which is mainly related to the dietary protein level. Failure to neutralise acidity leads to low-grade metabolic acidosis, with possible long-term deleterious effects on bone Ca status and on protein status. Furthermore, low-grade acidosis is liable to affect other metabolic processes, such as peroxidation of biological structures. These metabolic disturbances could be connected with the relatively high incidence of osteoporosis and muscle-protein wasting problems observed in ageing individuals in Europe and Northern America. Providing a sufficient supply of K organic anions through fruit and vegetable intake should be recommended, fostering the actual motivational campaigns ('five (or ten) per d') already launched to promote the intake of plant foods rich in complex carbohydrates and various micronutrients.