bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agreement between heart rate variability - derived vs. ventilatory and lactate thresholds A systematic review with meta-analyses
Authors: Tanner Valérian , Millet Grégoire P. , Bourdillon Nicolas 
Published: January 2024

Abstract

Background
This systematic review with meta-analyses aims to assess the overall validity of the first and second heart rate variability - derived threshold (HRVT1 and HRVT2, respectively) by computing global effect sizes for agreement and correlation between HRVTs and reference – lactate and ventilatory (LT-VTs) – thresholds. Furthermore, this review aims to assess the impact of subjects’ characteristics, HRV methods, and study protocols on the agreement and correlation between LT-VTs and HRVTs.
Methods
Systematic computerised searches for studies determining HRVTs during incremental exercise in humans were conducted between March and August 2023 using electronic databases (Cochrane Library, EBSCO, Embase.com, Google Scholar, Ovid, ProQuest, PubMed, Scopus, SportDiscus, Virtual Health Library and Web of science). The agreements and correlations meta-analyses were conducted using a random-effect model. Causes of heterogeneity were explored by subgroup analysis and meta-regression with subjects’ characteristics, incremental exercise protocols and HRV methods variables and compared using statistical tests for interaction. The methodological quality was assessed using QUADAS-2 and STARDHRV tools. The risk of bias was assessed by funnel plots, fail-safe N test, Egger's test of the intercept and the Begg and Mazumdar rank correlation test.
Results
Fifty included studies (1’160 subjects) assessed 314 agreements (95 for HRVT1, 219 for HRVT2) and 246 correlations (82 for HRVT1, 164 for HRVT2) between LT-VTs and HRVTs. The standardized mean differences were trivial between HRVT1 and LT1-VT1 (SMD = 0.08, 95% CI -0.04–0.19, n = 22) and between HRVT2 and LT2-VT2 (SMD = -0.06, 95% CI -0.15–0.03, n = 42). The correlations were very strong between HRVT1 and LT1-VT1 (r = 0.85, 95% CI 0.75–0.91, n = 22), and between HRVT2 and LT2-VT2 (r = 0.85, 95% CI 0.80–0.89, n = 41). Moderator analyses showed that HRVT1 better agreed with LT1 and HRVT2 with VT2. Moreover, subjects’ characteristics, type of ergometer, or initial and incremental workload had no impact on HRVTs determination. Simple visual HRVT determinations were reliable, as well as both frequency and non-linear HRV indices. Finally, short increment yielded better HRVT2 determination.
Conclusion
HRVTs showed trivial differences and very strong correlations with LT-VTs and might thus serve as surrogate thresholds and, consequently for the determination of the intensity zones. However, heterogeneity across study results and differences in agreement when comparing separately LTs and VTs to HRVTs were observed, underscoring the need for further research. These results emphasize the usefulness of HRVTs as promising, accessible, and cost-effective means for exercise and clinical prescription purposes
Activation of cannabinoid receptor 2 inhibits LPS-induced neuroinflammation via PI3K/Akt signaling pathway in mice
Authors: Wang Bingchao , denghan 邓晗 , Sui Yunjie , Liu Xinyu , Ren Yuqian , Ma ZeGang 
Published: January 2024

Abstract
Parkinson's disease (PD) is a common neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra (SN) and neuroinflammation mediated by overactivated microglia and astrocytes. Cannabinoid receptor 2 (CB2R) is primarily present on peripheral immune cells and microglia, exerts a significant immunomodulatory effect. However, its antineuroinflammatory effects and the precise mechanism are still unclear. Therefore, this study attempts to investigate the effect of CB2R on neuroinflammation and the underlying mechanisms.
Mice were injected with Lipopolysaccharide (LPS) into both sides of the SN using a stereotactic injection method to establish neuroinflammatory model. Pole test and rotarod test were performed to examine the ability of balance and motor coordination of mice. Immunohistochemistry (IHC) and immunofluorescence (IF) were performed on brain tissue sections to observe of tyrosine hydroxylase (TH), Iba1 and GFAP. RT-PCR was examined for inflammatory factors TNF-α, IL-6, IL-1β, iNOS and COX-2. The expression of PI3K/AKT signaling pathway-related proteins was examined by Western blot. Our studies showed that CB2R agonist (JWH133) protected dopaminergic neurons and improve motor dysfunction by inhibiting the activation of glial cells and the release of pro-inflammatory mediators in SN of mice induced by LPS. Furthermore, JWH133 also restored the phosphorylation of PI3K and Akt, which was downregulated by LPS in SN. However, CB2R knockout mice aggravated the loss of dopaminergic neurons and the decline of motor function. After CB2R knockout, the number of activated glial cells was significantly increased, and the expression of pro-inflammatory mediators was increased. The results suggested that activation of CB2R ameliorated LPS-induced neuroinflammation through the PI3K/Akt pathway.
Multi-frequency piezoelectric vibration energy harvesters powered sensing in power grid transformer
Authors: Wang Lu , Duan Congsheng , Li Chunlong , Wang Qian , Huang Hui , Ju Dengfeng , Liu Hongjing , Han Xiangguang , Zhao Libo , Jiang Zhuangde , MAEDA Ryutaro 
Published: January 2024

Abstract

With the development of smart grid, many wireless sensor nodes (WSN) used in monitoring grid equipment need continuous power supply. This work propose a multi-frequency array piezoelectric vibration energy harvester (PVEH) powering WSN based on the grid transformers vibration of 100, 200 and 300 Hz. The PZT bimorph with U shaped mass sturcture is design and opitimized by finite element simulation. The bonding method of epoxy conductivity and insulation is studied for PZT bimorph and aluminum packaged PVEHs. The equivalent circuit modeling and interface circuit of PVEHs are studied in LTspice simulation. Through the whole system design of the array PVEHs powered WSN circuit with LTC3331 chip, the WSN can run continuously in simultation and experimental verification. The feasibility of multi-frequency PVEH powered WSN is verified on the 500 kV transformer in filed operation. This research has important application value to the design of WSN self-power supply for smart grid.
A Highly Efficient Resource Slicing and Scheduling Optimization Algorithm for Power Heterogeneous Communication Networks Based on Hypergraph and Congruence Entropy
Authors: Wang Wendi , Jiang Chengling , Yang Linqing , Zhu Hong , Zhou Dongxu , Zhu Xiaorong 
Published: January 2024

Abstract
New services, such as distributed photovoltaic regulation and control, pose new service requirements for networks in the new power system. These requirements include low latency, high reliability, and large bandwidth. Consequently, power heterogeneous communication networks face the challenge of maintaining QoS while enhancing network resource utilization. Therefore, this paper puts forward a highly efficient optimization algorithm for resource slicing and scheduling in power heterogeneous communication networks. Our first step involves establishing an architectural description model of heterogeneous wireless networks for electric power based on hypergraph. This model characterizes complex dynamic relationships among service requirements, virtual networks, and physical networks. The system congruence entropy characterizes the degree of matching between the service demand and resource supply. An optimization problem is formed to maximize the system congruence entropy through dynamic resource allocation. To solve this problem, a joint resource allocation and routing method based on Lagrangian dual decomposition is proposed. These methods provide optimal solutions to the nodes and link mappings of service function chains. The results of our simulation demonstrate that the method proposed in this research enhances resource utilization and meets the QoS requirements of various services.
Are plant communities of roadside stormwater ponds similar to those found in natural wetlands?
Authors: D'Aoust Pierre-Alexandre Bergeron , Vaillancourt Mathieu , Pellerin Stéphanie , Poulin Monique 
Published: January 2024

Abstract

Stormwater ponds (SP) are increasingly used for water management along roads and in urban environments. How these constructed wetlands compare to natural wetlands in terms of biodiversity remains unclear, however. Studies to date have evaluated the subject in general terms, without considering the different habitats in SP and wetlands (from aquatic, at the pond edge, to terrestrial, at the upper bank) or other local and regional factors. This project aimed to compare the taxonomic diversity and composition of plant communities established in four different habitats of SP with that in either roadside or remote natural wetlands. We also evaluated the effect of various local and regional factors on those communities. Our results show that, globally, the species composition of the lower, wetter habitats was similar between SP and reference wetlands, especially roadside wetlands, while higher, drier habitats showed significant differentiation. Factors explaining observed differences between SP and both roadside and remote natural wetlands were water level fluctuations, road proximity, slope, and age of the SP. Stormwater ponds also exhibited lower beta diversity than both types of wetlands. Nonetheless, our study suggests that with some improvements in design, SP have the potential to more closely resemble natural wetlands.
Amorphous/crystalline heterostructured indium (III) sulfide/carbon with favorable kinetics and high capacity for lithium storage
Authors: Xue Yinghui , Xu Tianjie , Guo Yao , Song Haixiang , Wang Yuhua , Guo Zhanhu , Li Jianxin , Zhao Huihui , Bai Xiaojing , Lai Changwei 
Published: January 2024

Abstract

Nanostructured metal sulfides (MSs) are considered as prospective anodes for Li ion batteries (LIBs) due to their high specific capacity and abundant raw materials on Earth. Nerveless, the poor conductivity and volume expansion hinder their application. Here, we report the design of carbon coated indium sulfides nanotubes, where MIL-68 (In) metal-organic frameworks (MOF) as a precursor to generate In2S3/carbon (In2S3/C) through a solvothermal process. The construction of amorphous/crystalline structure not only combines the advantages of abundant ion channels of amorphous structure, but also has high crystal conductivity and promotes ion transport. The In2S3/C anode of LIBs exhibits excellent performance of 835 mAh·g− 1 at the current density of 0.5 A·g− 1 after 500 cycles. In2S3/C also shows outstanding long-term performance with 717 mAh·g− 1 at 2 A·g− 1. Through the kinetic analysis and ex situ XPS analysis, the lithium storage mechanism is realized. Further density functional theory (DFT) calculations indicate that In2S3/C electrodes have low adsorption energies and fast diffusion kinetics. In a word, the MOF-derived In2S3/C exhibits better electrochemical performances than commercial In2S3. This research will inspire the exploration of MSs as well as detect potential “diamonds in the rough”.
Diamond cutting and compliant morphable tool polishing of additively manufactured stainless steel
Authors: Nie Qianqian 
Published: January 2024

Abstract

The surfaces of additively manufactured (AMed) workpiece are generally very rough with many large pits and powder particles, which significantly limits their application. In this work, diamond cutting and compliant morphable tools polishing were proposed to finish AMed stainless steel. The surface morphology, indentation hardness and friction coefficient of the as-built, diamond cut and polished workpiece were measured and analyzed. The results show that grinding was able to reduce the roughness of the as-built sample to 2.4 µm. Diamond cutting and polishing significantly reduced the roughness Sa, Sq of the sample from more than 10 µm to 80 nm, 90 nm and 3 nm, 5 nm, respectively. Besides, the sample surface protrusions and valleys were significantly reduced from ~ 50 µm, ~ 30 µm to ~ 0.6 µm, ~ 0.3 µm by diamond cutting and ~ 0.2 µm, 0.1 µm by polishing. The 9 µm abrasive polished surface was flat with some left particles and irregular abrasion marks while the 0.3 µm abrasive polished surface was flatter with no observable protrusions or marks. Polishing made the nanoindentation load-depth curves more identical, and increased the indentation hardness and modulus, and decreased the indentation depth than those on the cut surface. The friction coefficients on the as-built surface were 0.64–0.82. Diamond cutting and polishing greatly reduced the friction coefficients to 0.49 and 0.46.
Production of Iron-enriched Yeast and it’s application in the treatment of iron-deficiency anemia
Authors: Chen Ying , Pang Yuanxiang , Wan Hongbing , Zhou Xinyi , Wan Mingli , Li Shengshuo , Liu Xuelian 
Published: January 2024

Abstract
Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition.Wild type strains of Saccharomyces cerevisiae have higher tolerance to inorganic iron and higher iron conversion and accumulation capacity.The aim of this study was to investigate the effect of yeast iron as a potential organic iron supplement on mice with iron deficiency anemia.60 male KM mice were randomly divided into normal control group and iron deficiency diet model group to establish IDA model. After the model was established, IDA mice were randomly divided into 5 groups: normal control group, IDA group, organic iron (Fe-Gly) group, inorganic iron (FeSO4) group and yeast iron (Fe-F8) group.Mice in the experimental group were given different kinds of iron by intragastric administration once a day for 4w.The results showed that Fe-F8 had an effective recovery function, and the body weight and hematological parameters of IDA mice returned to normal levels. The activities of malondialdehyde, superoxide dismutase, glutathione peroxidase and total antioxidant capacity in serum were increased.In addition, Fe-F8 was more effective in alleviating IDA and improving organ indices with fewer side effects compared to ferrous glycinate and ferrous sulfate groups. This study suggests that the iron-rich strain F8 may play an important role in improving IDA mice and may be developed as a new iron supplement.
Optimizing Transition: Investigating the Influence of Operational Parameters on Production Scheduling Optimization for Mines Transitioning from Open Pit to Block Caving Methods
Authors: Flores Ignacio Ortiz , Anani Angelina , Li Haitao , Jalilzadeh Afrooz 
Published: January 2024

Abstract
Current technologies have made the transition from surface to underground mining methods for mineral extraction feasible and economically viable. Determining the point of transition from one method to the other for deposits that require exploitation with both methods is challenging. The existing research integrates production scheduling optimization with determining the transition depth that maximizes net present value (NPV), making the problem computationally intractable. However, these studies do not consider some realistic operational constraints in the problem setting. Our paper aims to develop an integrated mixed-integer linear programming (MILP) model to investigate the extent to which operational constraints and parameters of transition mines affect the optimal production schedule and NPV of an operation. We developed a computational experiment that evaluates development cost and rate, fleet size, stockpile, production footprint, dilution factor, and crown pillar placement on the model output. A case study is used to validate the model, with a comparative sensitivity analysis to obtain operational insights. The sensitivity of the NPV and computational time to each experimental factor varied significantly. There was no significant difference in NPV (0.15%) when the development cost was incorporated. However, for the fleet size, stockpile, and production footprint, an increase of 4.8%, 10.5 %, and 4.8% in the NPV was observed. We conclude that the extent to which operational parameters and constraints of transition mines are accounted for, has a significant impact on the optimal production schedule and NPV obtained.
Soil microbial community composition and nitrogen enrichment responses to the operation of electric power substation
Authors: Xu Zhi-Xin , Zeng Bo , Chen Sheng , Xiao Sa , Jiang Lin-Gao , Li Xiang , Wu Yun-Fang , Zhao Meng-Xin , Chen Si-Ru , You Le-Xing X. 
Published: January 2024

Abstract
The surge in global energy demand mandates a significant expansion of electric power substations. However, the ecological consequences of electric power substation operation on soil microbial communities and nitrogen enrichment have not been addressed. In this study, we collected soil samples from seven distinct sites at varying distances from an electric power substation in Xintang village, southeastern China, and investigated the microbial diversity and community structures employing metagenomic sequencing technique. Key environmental determinants shaping soil microbial communities at both the phylum and genus levels were identified as soil moisture content, pH and electric conductivity. Prominent taxa identified across all sampled soils included Acidobacteria, Proteobacteria, Actinobacteria, Chloroflexi, Basidiomycota, Ascomycota, and Mucoromycota. While the bacterial community exhibited statistically significant differences across the seven distinct sites, fungal communities did not show such variations. Correlation analysis revealed a diminished nitrogen fixation capacity at the site nearest to the substation, characterized by low moisture content, elevated pH, and robust soil electric conductivity. In contrast, heightened nitrification processes were observed at this site compared to others. These findings were substantiated by the relative abundance of key genes associated with ammonium nitrogen and nitrate nitrogen production. This study provides insights into the relationships between soil microbial communities and the enduring operation of electric power substations, thereby contributing fundamental information essential for the rigorous environmental impact assessments of electric power substations.
Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes
Authors: Zhang Hengliang , Sen Payel , Hamers Jules , Sittig Theresa , Woestenburg Brent , Moretti Allessandra , Dendorfer Andreas , Merkus Daphne 
Published: January 2024

Abstract
Background. Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocyte cells. Retinoic acid (RA) plays an important role in regulation of the spatiotemporal development of the embryonic heart.
Methods: Engineered heart tissues (EHTs) were generated by assembling CMs derived from hiPSC (hiPSC-CM) at high cell density in a low collagen hydrogel. Different concentrations of RA (Control group without RA, LRA group with 0.05 µM and HRA group with 0.1 µM) were administered during third to sixth days of the differentiation process.
Results: In the HRA group, hiPSC-CMs exhibited highest expression of maturity genes MYH7 and cTnT. The expression of TBX5, NKX2.5 and CORIN, which are the marker genes for left ventricular CMs, was also the highest in the HRA group. In terms of EHT, the HRA group displayed the highest contraction force, the lowest beating frequency, and the highest sensitivity to hypoxia and isoprenaline, which means it was more functionally similar to the left ventricle. RNAsequencing revealed that the heightened contractility of EHT within the HRA group can be attributed to the promotion of augmented extracellular matrix strength by RA.
Conclusion: By interfering with the differentiation process of hiPSC with a specific concentration of RA at a specific time, we were able to successfully induce CMs and EHTs with a phenotype similar to that of the left ventricle or right ventricle.
Enhancing Risk Assessment Models for Heavy Duty and Medium Duty Vehicles through Customization of the EVITA Framework
Authors: Rahimi Narges , Mirhassani Mitra , Schuelke-Leech Beth-Anne 
Published: January 2024

Abstract

As a cornerstone of cybersecurity, risk assessment facilitates identifying and grading potential threats. Despite several risk assessment methodologies tailored for the automotive industry, such as EVITA and HEAVEN, a substantial knowledge gap persists in the context of heavy-duty (HD) and medium-duty (MD) vehicles. This study seeks to bridge this gap by introducing a customized model derived from EVITA, specifically designed for HD/MD vehicles. This model enhances the existing EVITA framework by integrating updated severity and probability weights that reflect the unique applications of HD/MD vehicles. Additionally, the attack tree initially presented in EVITA, is augmented by incorporating Common Weakness Enumeration (CWE) and Common Vulnerabilities and Exposures (CVE) standards. This research presents a comprehensive risk assessment methodology for HD/MD vehicles by building upon the EVITA model. The revised severity and likelihood weighting and the integration of CWE and CVE result in a more precise and effective strategy for assessing and mitigating potential risks. The insights gained from this research contribute to the evolution of risk assessment techniques in the automotive industry, with a particular emphasis on heavy-duty and medium-duty vehicles.
Subsurface mixing and ventilation of oxygen minimum zone waters in the southern Bay of Bengal during the summer monsoon
Authors: Roy Rajdeep , Vinayachandran P. N. , George Jenson , Sarkar Amit , Parida Chandanlal 
Published: January 2024

Abstract

During the summer monsoon, the local wind forcings around Sri Lanka causes the formation of a cold dome called the Sri Lanka Dome (SLD), which upwells subsurface waters. To the east of SLD, the summer monsoon current (SMC) flows into the Bay of Bengal (BoB), transporting high-salinity water from the Arabian Sea. We show that the SMC and the upwelled waters of the SLD are ventilated episodically during summer monsoon in the southern BoB, leading to a net exchange of low oxygen subsurface waters with saturated mixed layers. We observed presence of hypoxic boundary < 63 µmol kg− 1 very close to the surface. Within the SLD, it shoaled between 35 to 40 m, with oxygen values reaching as low as 6 µmol kg− 1 at the bottom of the thermocline. Negative fluxes showing the ingassing rates ranged between − 0.33 and − 9.43 µmol m− 2 sec− 1 within the SLD and SMC. We propose that the episodic ventilation seen during this investigation may lead to disequilibrium between mixed layer and below thereby contributing to mid-depth oxygen enrichment. This study possibly illustrates a pathway through which the oxygen minimum zone in BoB may be gaining oxygen, thereby preventing from becoming denitrifying.
General Relativistic Approach to the Vis-viva Equation
Authors: Peng Qi , Yokoyama Shuichiro , Ichiki Kiyotomo 
Published: January 2024

Abstract
A modification to the vis-viva equation that accounts for general relativistic effects is introduced to enhance the accuracy of predictions of orbital motion and precession. The updated equation reduces to the traditional vis-viva equation under Newtonian conditions and is a more accurate tool for astrodynamics than the traditional equation. Preliminary simulation results demonstrate the application potential of the modified vis-viva equation for more complex n-body systems. Spherical symmetry is assumed in this approach; however, this limitation could be removed in future research. This study is a pivotal step toward bridging classical and relativistic mechanics and thus makes an important contribution to the field of celestial dynamics.