bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial communities of Iradiator Gamma Karet Alam (IRKA) pool water
Authors: Sugoro I , Mujiyanto A , Tetriana D , Tjiptosumirat T , Tuasikal B J , Robifahmi N , Rahma F J , Santiara R , Fadhlany M M , Yunus M Y , Ambudi D R S , Cici A , Shalsabilla S E , Fadila D S R , Sanjaya M F , Sambari R R , Ramadhan F , Hermanto F E , Rijal M S 
Published: December 2023

Abstract
Bacteria which are living in extreme environment have potential for bioprospection as candidates for drug discovery and bioremediation. Radiation-resistant bacteria can be obtained from environments that have radiation sources. Pool water containing radioactive material is one of the important components in the Iradiator Gamma Karet Alam (IRKA) facility. Research on the presence of bacterial communities in the IRKA cooling pool water has never been conducted. This study was conducted to determine the bacterial community of IRKA cooling pool water using Nanopore Sequencing. The study identified 7 phyla, with Proteobacteria and Firmicutes as the dominant with 95.9 and 3.9%, respectively. Phreatobacter, specifically P. oligotrophus, emerged as the dominant genus and the most prevalent species, constituting 71.22% of the cooling pool water samples at the IRKA facility. The limited number of studies conducted on these dominant species presents an opportunity for further exploration of their potential benefits.
Diversity of brachyuran crab (Crustacea: Decapoda) in West Coast of North Sumatra, Indonesia
Authors: Hanim N , Siregar N A , Saputra R T , Widayati K A , Farajallah A 
Published: December 2023

Abstract
The west coast of Sumatra is a water area with a high potential for fishery products. One of the areas, (i.e., Sibolga City) is a national fishery center in Indonesia. The high productivity of these waters is supported by the presence of keystone species in nature, one of which is the crab (infraorder Brachyura). This study aims to record brachyuran species on the west coast of Sumatra that are still unknown. Sampling was conducted in Central Tapanuli Regency and Sibolga City using convenience sampling. The samples obtained were 50 individuals. Based on the identification, the sample consisted of 22 species belong to 6 families. Fourteen species is first recorded in this region, and five species are new records in Indonesia.
Producing ethanol from coconut sap using yeast isolates R513, IS258 and Saccharomyces cerevisiae ATCC 9763 and the optimal fermentation time required
Authors: Sujana I G A , Gunam I B W , Wijaya I M M , Putra I W W P 
Published: December 2023

Abstract
Energy requirements continue to rise despite depletion of fossil energy. Therefore, environmentally friendly renewable alternative energy is needed including bioethanol. Microbial assistance is usually required to convert the sugar content from sugary content (coconut sap) into ethanol. This study was aimed to determine the performance of several microbes and the optimum fermentation time for bioethanol production from coconut sap. Randomized block design with 2 factors was used, where the 1st factor was the type of microbes consisting of isolates R5I3, IS258, and S. cerevisiae ATCC 9763, and the 2nd factor was the fermentation time, namely: 0, 1, 2, 3, and 4-days. The results showed that the best isolate for producing bioethanol from coconut sap was isolate IS258, followed by isolate R5I3 with the least was S. cerevisiae ATCC 9763. Isolate IS258, R5I3, and S. cerevisiae ATCC 9763 was able to produce ethanol of 6.18±0.45%, 5.39±0.21% v/v, and 4.65±0.83% v/v, respectively and in 3, 3, and 4 days of fermentation, respectively. In the process of bioethanol production based on coconut sap, IS 258 isolates is potentially be used in the production process in the future.
Exploring the influence of maitake (Grifola frondosa) on Mus musculus learning-memory and anxiety behavior
Authors: Fadilah N D N , Listiyowati S , Juliandi B 
Published: December 2023

Abstract
Progressive neurodegeneration affect memory and behavior. One solution to increase neuroprotection is the consumption of medicinal mushrooms such as Grifola frondosa. This study aims to analyze the effect of G. frondosa extract on learning-memory and anxiety levels in mice. Mycelium was cultured in Potato Sucrose Broth medium at room temperature for 14 days. Dried mycelial was extracted using a solvent mixture (22% ethyl acetate and 11% methanol). Learning-memory and anxiety levels were observed using Y-Maze Alternation (Y-Maze) test, Morris Water Maze (MWM) test, Novel Object Recognition test, and Light and Dark Transition test. A total of 18 male mice were divided into three groups and given oral treatment for 14 days: control (distilled water), GF100 (extract of 100 mg/kg BW), and GF200 (crude extract of 200 mg/kg BW). The GF100 and GF200 groups increased spatial learning-memory in Y-Maze and novel object recognition memory, but both treatment groups did not significantly affect anxiety and learning-memory in MWM.
The use of propolis in ointment ingredient for the treatment of dermatophytosis infection
Authors: Kusumaningtyas E , Endrawati D , Siswandi R 
Published: December 2023

Abstract
Dermatophytosis in animals is very important since it is zoonotic. Propolis is a promising natural compound against pathogenic fungi since there is an increasing need to discover less expensive, more natural, and more accessible treatments. The purpose of this study was to evaluate propolis as an anti-dermatophyte and topical drug preparation against Trichophyton mentagrophytes. Propolis was tested for its antifungal properties at various concentrations using the diffusion method. The ointment was applied to the rabbit with dermatophytosis after being prepared by combining the ointment base with 10% propolis. The result demonstrated that propolis was able to inhibit the growth of Trichophyton mentagrophytes which was indicated by a clear zone around the disc. Propolis ointment helped lessen inflammation more than Miconazole 2% at severe lesions, according to in vivo trials on rabbits, while the two ointment’s healing times were nearly identical. According to the findings, propolis is a promising ointment ingredient for the treatment of dermatophytosis.
The clove essential oil and its combination with galangal oil exhibit antibacterial activity, potential as antiseptic agent
Authors: Dany R R , Astuti R I , Priyanto J A 
Published: December 2023

Abstract
Essential oils are known and have been tested for their antimicrobial properties. Previous studies have tested the antimicrobial activity of clove and galangal essential oils alone. Thus, the purpose of this study was to determine the antimicrobial activity of clove and galangal essential oils alone as well as their combinations. The screening of antimicrobial activity was performed by disc diffusion assay against Gram-positive bacteria and Gram-negative bacteria. Both essential oils showed antimicrobial activity against Escherichia coli at 10% (v/v) concentration. Furthermore, five combinations of clove and galangal essential oils were made and tested at 1:1, 7:3, 9:1, 3:7, and 1:9 ratio. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of three combinations with the highest activity were performed against Escherichia coli. The MIC and MBC of clove oil is at 2.5% (v/v) and 5% (v/v) while the MIC and MBC of Galangal oil is at 5% (v/v) and 10% (v/v). All three combinations showed MIC and MBC value is at 5% (v/v) and 10% (v/v) respectively. In addition, based on SNI EN 1276:2019 assay, the clove and galangal essential oil as well as their combinations meet the requirement as antiseptic agent against E. coli.
In silico analysis of trisindoline 1 as tyrosinase inhibitors
Authors: Sukma C M , Nurhayati A P D , Santoso M 
Published: December 2023

Abstract
Hyperpigmentation is darkening condition in the skin area due to excessive melanin production. This condition interferes with skin aesthetics and can increase the production of reactive oxygen species which can cause skin damage. The widely targeted approach to treat hyperpigmentation is inhibition of tyrosinase. Trisindoline is a compound synthesized from the marine sponge Hyrtios altum and has high bioactivity potential. Trisindoline itself has been shown in vitro to inhibit tyrosinase. Thus, trisindoline was synthesized into four derivatives, one of which was trisindoline 1 with the addition of a nitro group. This paper aims to determine the potency of trisindoline 1 as tyrosinase inhibitors and then compared with commercial tyrosinase inhibitors, kojic acid and arbutin, in silico. In silico analysis was carried out by molecular docking of trisindoline 1 to tyrosinase using AutoDock Vina. Kojic acid was used as the native ligand and arbutin as the control ligand. Visualization of molecular docking results using BIOVIA Discovery Studio. The binding affinity score obtained indicates that trisindoline 1 has the lowest binding score. It is -9.2 kcal/mol to the tyrosinase enzyme. These results indicate that trisindoline 1 has the potential as a candidate for anti-hyperpigmentation agents through the mechanism of tyrosinase inhibitors.
Effect of coconut water on in vitro propagation of Hylocereus costaricensus and acclimatization
Authors: Norrizah J S , Aisyah M N Siti , Wan Razarinah W A R 
Published: December 2023

Abstract
Red-purple dragon fruit, Hylocereus costaricensis (Web.) Britton & Rose belongs to Cactaceae family. Due to its high nutraceutical ingredients has attracted a lot of attention to alternative propagate this species through in vitro culture technique. This research was aimed to analysed the effects of different concentrations of coconut water on the growth of H. costaricensis stem explants in Murashige and Skoog (MS) and Vacin and Went (VW) media. Then, combination of soil and coconut coir or coconut husk were used as planting media during acclimatization was investigated. Findings showed that in MS and VW supplemented with 5% coconut water formed 100% of shoot and root. VW media supplemented with 5% of coconut water yielded the highest average number of shoots (6.28 ± 0.48) and the longest shoot (3.85 ± 0.23 cm). The longest root (7.00 ± 0.66 cm) was observed on MS media supplemented with 5% coconut water whereas VW media supplemented with 5% coconut water produced the highest average number of roots (2.40 ± 0.19). Addition of coconut water can stimulate better shoot and root formation as it contains naturally plant growth regulators. During acclimatization, combination of soil and coconut coir showed the highest percentage (100%) of survival rate.
Multifunctional optical logic device based on nanoscale rectangular ring resonator
Authors: Chai Junxiong , Xie Yiyuan , Tan Jing , Jiang Xiao , Chen Yan 
Published: December 2023

Abstract
Integrated optical logic devices are essential building blocks for implementing all-optical arithmetic and logic unit. In this paper, an ultra-compact multifunctional optical logic device consisting of a rectangular ring resonator coupled with two parallel metal–insulator–metal waveguides is presented. The transmission characteristics of the structure are analyzed in detail via temporal coupled-mode theory. The finite-difference time-domain simulation results reveal that multiple logic functions can be implemented with the aid of the wavelength division multiplexing technique at different output ports. Specifically, all seven basic types of logic gates, half-adder, half-subtractor, and 2*4 decoder can be implemented by monitoring the transmission of through and drop ports at different wavelengths. More importantly, among these functions, six logic gates (OR, XNOR, NAND, NOR, XOR, and AND) and half-adder functions can be performed simultaneously; the NOT logic operation is performed with controllable output ports and selectable working wavelengths; the half-subtractor and 2*4 decoder functions can be operated simultaneously. The proposed logic device is characterized by a small area overhead, multifunctionality, fast response time, and ultrahigh-speed information processing. It may potentially be applied in on-chip universal and parallel photonic computing units.
What next for marine ecosystem management in Vietnam: assessment of coastal economy, climate change, and policy implication
Authors: Giang Pham Quy , Khanal Rajendra 
Published: December 2023

Abstract
Vietnam is a coastal country with a coastline stretching more than 3,260 km. Marine resources are important for the development of Vietnam. In Vietnamese seas, there are about 20 typical ecosystems spreading over 1 million square kilometers in the East Sea consisting of mangrove forests, coral reefs, lagoons, seagrasses in intertidal areas and estuaries, and living species in 155,000 hectares, 1,300 square kilometers, 500 square kilometers, 16,000 hectares, and 11,000 living species, respectively. At present, the impact of climate change, socio-economic development, and environmental pollution are considered as the main causes of degradation of Vietnam’s marine ecosystems. This paper presents and discusses the pressure of socio-economic activities including industry, tourism, marine transportation and services, aquaculture and fishery on marine ecosystems. In Vietnam, compared to the early 2000s a total of 12% of coral reefs, and 48% of other coral reefs are vulnerable to degradation. So far, about 100 species of marine life in Vietnam are at risk of being threatened due to over-exploitation and fishing. The seagrass-bed ecosystem is currently being degraded with only over 5,580 ha remaining. In some areas, such as Cat Ba, Ha Long, and Quang Nam, seagrass beds have almost no chance to recover naturally due to serious impacts from tourism and aquaculture activities. From the findings, orientations that aim at effective management and protection of marine ecosystems to cope with adverse impacts of anthropogenic activities, climate change, and the pressure of socioeconomic development were proposed.
Characterisation and evaluation of the harmonic content of involute gear surface deviations
Authors: Reavie Tom , Frazer Robert , Przyklenk Anita , Stein Martin 
Published: December 2023

Abstract
Gears are fundamental precision components that are crucial to many industries, including the wind energy sector. They are traditionally analysed using profile and helix line measurements but this does not consider the majority of the contacting surface with intricate surface variations that dictate functional performance. Practical measurement and evaluation of involute gear surfaces remain underexplored. This paper uses the Fourier and wavelet transforms to evaluate measured gear surface deviation harmonic content for a single trace, a trace set, and surface analysis and describes the utility of each. The methods are first demonstrated with synthetic data and then with measured data, then the measured data is simulated in a quasi-static FE tooth contact analysis, which yields insights not solely gleaned from harmonic analysis. The uncertainty of harmonic content analysis is to be established in future work and how that effects the uncertainty of simulated functional performance should be investigated.
Mobile applications to prescribe physical exercise in frail older adults: review of the available tools in app stores
Authors: Soto-Bagaria Luis , Eis Sophie , Pérez Laura Mónica , Villa-García Lorena , de Solà-Morales Oriol , Carrion Carme , Giné-Garriga Maria , Inzitari Marco 
Published: December 2023

Abstract

Introduction
Different remote interventions, such as applications (apps), have been used to continue promoting healthy ageing and preventing disability during the COVID-19 pandemic. The growing trend of apps in health is exponential and may facilitate scaling up physical activity prescription. Numerous tools are available, but little is known regarding their appropriateness, validation and recommendation, especially for frail older adults.

Methods
In-house, we developed an application that makes both the Apple app Store and the Google Play Store searchable using topic-related keywords and facilitates the extraction of basic app-information of the search results. The study was aimed at apps available to an English-speaking market. The resulting apps were filtered using various inclusion and exclusion criteria. The resultant apps underwent a more in-depth characterisation and searches for scientific publications on each app website and PubMed.

Results
From an initial search result of &gt;2,800 apps, 459 met the initial inclusion criteria. After a more in-depth review of their features, 39 apps remained for possible app in older frail patients. After testing them, 22 apps were excluded. Seventeen apps fit the inclusion and exclusion criteria and were deemed appropriate after peer review. Of these, only one app, Vivifrail, had any type of publication/published evidence.

Conclusion
Apps can be valuable tool in prescribing exercise for frail older adults living in the community. However, few apps seem useful on a large scale, and there is limited evidence to support their effectiveness. It is important to invest in adapting Information and Communication Technologies to this population group.
Stepping into the shoes of older people: a scoping review of simulating ageing experiences for healthcare professional students
Authors: Nelson Elaine E C , Spence Andrew D , Gormley Gerard J 
Published: December 2023

Abstract

Background
Ageing simulation suits and equipment give healthcare professional (HCP) students the opportunity to experience what it might feel like to be an older person with age-related disability or illness. Ageing simulation experiences, where students complete activities of daily living (ADL) tasks, aim to reproduce the challenges an older person may face.

Objectives
We undertook a scoping literature review to establish, from the evidence base, what is known about simulating ageing experiences for HCP students and its impact on attitudes towards older patients.

Methods
We applied Arksey and O’Malley’s scoping literature review framework to achieve relevant articles. Four databases (MEDLINE, Embase, Web of Science and Cumulative Index to Nursing and Allied Health Literature) were searched resulting in 114 citations. After screening and applying our exclusion criteria, 14 articles were selected for inclusion.

Results
Fifty percent of studies were mixed-methods, 35% quasi-experimental, 7% quantitative and 7% qualitative. Two types of simulation experience were identified: (i) workshop based and (ii) ageing games. Simulated impairments included vision, hearing and mobility issues. Most common ADLs simulated were managing medications, finances and functional ability. The majority of studies reported a positive impact on knowledge, attitudes and empathy towards older people.

Conclusions
Teaching in Care of Older People is important in HCP undergraduate curricula and should be a positive experience promoting successful ageing while raising awareness of ageism. Ageing suits have a positive impact on students’ attitudes and empathic skills towards older people. Future research should include interprofessional education with HCP students learning together throughout undergraduate training.
Implementation of pharmacist-led services for sexual and gender minorities: A multisite descriptive report
Authors: Phan Tam , Astle Kevin N , Mills Alex R , Medlin Christopher G , Herman David 
Published: December 2023

Abstract

Purpose
This paper compares and contrasts the implementation of pharmacist-led services for 3 different sexual and gender minority populations across California, Mississippi, and Florida.

Summary
Implementation of pharmacist-led services tailored to sexual and gender minorities may be a potential mechanism to address health disparities in these populations. Clinical pharmacists have the potential to provide care with cultural humility and improve health outcomes by optimizing medication regimens, reducing adverse drug events, enhancing medication acquisition, and improving medication adherence.

Conclusion
The services provided by clinical pharmacists varied across sites and included management of gender-affirming hormone therapy, HIV antiretroviral medication adherence programming, primary care and chronic disease state management, and involvement in care related to mental health, psychiatry, and substance use as well as sexual health. Various legislative and regulatory barriers and differences in scope of practice for pharmacists were also identified. This paper advocates for the expansion of pharmacy-led services and the adoption of a culturally humble approach to patient care.
VIPpred: a novel model for predicting variant impact on phosphorylation events driving carcinogenesis
Authors: Xu Xiaofeng , Li Ying , Chen Taoyu , Hou Chao , Yang Liang , Zhu Peiyu , Zhang Yi , Li Tingting 
Published: December 2023

Abstract
Disrupted protein phosphorylation due to genetic variation is a widespread phenomenon that triggers oncogenic transformation of healthy cells. However, few relevant phosphorylation disruption events have been verified due to limited biological experimental methods. Because of the lack of reliable benchmark datasets, current bioinformatics methods primarily use sequence-based traits to study variant impact on phosphorylation (VIP). Here, we increased the number of experimentally supported VIP events from less than 30 to 740 by manually curating and reanalyzing multi-omics data from 916 patients provided by the Clinical Proteomic Tumor Analysis Consortium. To predict VIP events in cancer cells, we developed VIPpred, a machine learning method characterized by multidimensional features that exhibits robust performance across different cancer types. Our method provided a pan-cancer landscape of VIP events, which are enriched in cancer-related pathways and cancer driver genes. We found that variant-induced increases in phosphorylation events tend to inhibit the protein degradation of oncogenes and promote tumor suppressor protein degradation. Our work provides new insights into phosphorylation-related cancer biology as well as novel avenues for precision therapy.
Angiosperm fossil woods from the Upper Cretaceous (Cardiel Formation) of Argentinean Patagonia
Authors: Rombola Cosme F , Pujana Roberto R , Ruiz Daniela P , Bellosi Eduardo S 
Published: December 2023

Abstract
We describe nine angiosperm fossil woods from sediments of the Cardiel Formation (Upper Cretaceous) near the Cardiel Lake, Santa Cruz Province, Argentinian Patagonia. On the basis of the characteristics of the anatomy, the specimens were placed in three fossil species: Weinmannioxylon trichospermoides related to the Cunoniaceae, Burseroxylon panzai sp. nov. possibly related to the Anacardiaceae or Burseraceae, and a new taxon with unknown affinity, Tortorellixylon oligoporosum gen. et sp. nov. Angiosperms are 15% of the assemblage and conifers 85%, which is consistent with previous studies of fossil woods from the Late Cretaceous of Patagonia. Most specimens show poorly distinct growth ring boundaries that suggest a weakly marked annual seasonality during the deposition of the Cardiel Formation. In addition, the specimens’ size and the rings’ curvature are consistent with large trees. Decay patterns similar to those produced by modern xylophagous fungi are also recognized in most specimens. The identification of three species in an assemblage of nine fossil woods suggests a significant taxonomic richness of angiosperms, and the taxonomic composition suggests a Late Cretaceous age for the Cardiel Formation (probably Campanian–Maastrichtian). These new records allow a better understanding of the composition of the fossil forests of the Late Cretaceous of Patagonia, in which the tree canopy was apparently dominated by conifers.