bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Breast Cancer Mortality in the US—1975 to 2019
Authors: Caswell-Jin Jennifer L. , Sun Liyang P. , Munoz Diego , Lu Ying , Li Yisheng , Huang Hui , Hampton John M. , Song Juhee , Jayasekera Jinani , Schechter Clyde , Alagoz Oguzhan , Stout Natasha K. , Trentham-Dietz Amy , Lee Sandra J. , Huang Xuelin , Mandelblatt Jeanne S. , Berry Donald A. , Kurian Allison W. , Plevritis Sylvia K. 
Published: January 2024

ImportanceBreast cancer mortality in the US declined between 1975 and 2019. The association of changes in metastatic breast cancer treatment with improved breast cancer mortality is unclear.ObjectiveTo simulate the relative associations of breast cancer screening, treatment of stage I to III breast cancer, and treatment of metastatic breast cancer with improved breast cancer mortality.Design, Setting, and ParticipantsUsing aggregated observational and clinical trial data on the dissemination and effects of screening and treatment, 4 Cancer Intervention and Surveillance Modeling Network (CISNET) models simulated US breast cancer mortality rates. Death due to breast cancer, overall and by estrogen receptor and ERBB2 (formerly HER2) status, among women aged 30 to 79 years in the US from 1975 to 2019 was simulated.ExposuresScreening mammography, treatment of stage I to III breast cancer, and treatment of metastatic breast cancer.Main Outcomes and MeasuresModel-estimated age-adjusted breast cancer mortality rate associated with screening, stage I to III treatment, and metastatic treatment relative to the absence of these exposures was assessed, as was model-estimated median survival after breast cancer metastatic recurrence.ResultsThe breast cancer mortality rate in the US (age adjusted) was 48/100 000 women in 1975 and 27/100 000 women in 2019. In 2019, the combination of screening, stage I to III treatment, and metastatic treatment was associated with a 58% reduction (model range, 55%-61%) in breast cancer mortality. Of this reduction, 29% (model range, 19%-33%) was associated with treatment of metastatic breast cancer, 47% (model range, 35%-60%) with treatment of stage I to III breast cancer, and 25% (model range, 21%-33%) with mammography screening. Based on simulations, the greatest change in survival after metastatic recurrence occurred between 2000 and 2019, from 1.9 years (model range, 1.0-2.7 years) to 3.2 years (model range, 2.0-4.9 years). Median survival for estrogen receptor (ER)–positive/ERBB2-positive breast cancer improved by 2.5 years (model range, 2.0-3.4 years), whereas median survival for ER−/ERBB2− breast cancer improved by 0.5 years (model range, 0.3-0.8 years).Conclusions and RelevanceAccording to 4 simulation models, breast cancer screening and treatment in 2019 were associated with a 58% reduction in US breast cancer mortality compared with interventions in 1975. Simulations suggested that treatment for stage I to III breast cancer was associated with approximately 47% of the mortality reduction, whereas treatment for metastatic breast cancer was associated with 29% of the reduction and screening with 25% of the reduction.
Ligand‐Selective Targeting of Macrophage Hydrogel Elicits Bone Immune‐Stem Cell Endogenous Self‐Healing Program to Promote Bone Regeneration
Authors: Wang Jiahao , Zhang Liang , Wang Lingjun , Tang Jincheng , Wang Wei , Xu Yichang , Li Ziang , Ding Zhouye , Jiang Xinzhao , Xi Kun , Chen Liang , Gu Yong 
Published: January 2024

AbstractTargeting macrophages can facilitate the site‐specific repair of critical bone defects. Herein, a composite hydrogel, gelatin‐Bletilla striata polysaccharide‐mesoporous bioactive glass hydrogel (GBMgel), is constructed via the self‐assembly of mesoporous bioactive glass on polysaccharide structures, through the Schiff base reaction. GBMgel can efficiently capture macrophages and drive the recruitment of seed stem cells and vascular budding required for regeneration in the early stages of bone injury, and the observed sustained release of inorganic silicon ions further enhances bone matrix deposition, mineralization, and vascular maturation. Moreover, the use of macrophage‐depleted rat calvarial defect models further confirms that GBMgel, with ligand‐selective macrophage targeting, increases the bone regeneration area and the proportion of mature bone. Mechanistic studies reveal that GBMgel upregulates the TLR4/NF‐κB and MAPK macrophage pathways in the early stages and the JAK/STAT3 pathway in the later stages; thus initiating macrophage polarization at different time points. In conclusion, this study is based on the endogenous self‐healing properties of bone macrophages, which enhances stem cell homing, and provides a research and theoretical basis upon which bone tissue can be reshaped and regenerated using the body's immune power, providing a new strategy for the treatment of critical bone defects.
High Performance Self‐Powered and Vis–Infrared Broadband Photodetectors Based on MoTe2/InSe Van der Waals Heterostructure
Authors: He Sixian , Feng Pu , Du Yuan , Ma Yupeng , Dang Congcong , Shan Aidang , Zhao Liancheng , Wei Tian‐Ran , Li Ming , Gao Liming 
Published: January 2024

AbstractSelf‐powered and broadband photodetectors have important applications in modern technologies and have garnered significant research interest with the increasing concern for green and energy‐saving. The emerging 2D materials InSe is considered to be a promising candidate for next‐generation photodetectors due to the high carrier mobility, excellent photoelectric response, and flexibility. However, due to its weak absorption of infrared light, it remains a challenging task to achieve high‐performance, self‐powered, and broadband photodetection. Here, a MoTe2/InSe van der Waals heterostructure (vdWH) device is successfully constructed. Benefiting from the unique band alignment of the heterostructure, a strong built‐in electric field is formed. Excitingly, the device exhibits excellent photovoltaic performance with a large open voltage and short circuit current of 390.19 mV and 20.32 nA, respectively. In particular, in self‐powered mode, the responsivity (R) is up to 433.88 mA W−1 and the specific detectivity (D*) reaches 1.65 × 1012 Jones under 405 nm irradiation. Meanwhile, an ultrahigh Ilight/Idark ratio over 104, a fast response speed of 99/117 µs, and a broadband photoresponse range from 405 to 980 nm are achieved. The device demonstrates excellent comprehensive self‐powered photodetection performance. This work reveals the great potential of the MoTe2/InSe vdWH for high‐performance, broadband, and self‐powered photodetection.
Chiral Multidentate Ligand Facilitating Perovskite Nanocrystals with Circularly Polarized Luminescence and Chiral Assembly
Authors: Chen Shuhua , Fu Jie , Zhang Congyang , Hu Yiqi , Qiu Yinghua , Chen Jinxing , Zhang Qiao , Cao Muhan 
Published: January 2024

AbstractChiral ligand modification has emerged as a promising route to confer intrinsic chirality in perovskite nanocrystals (NCs), thereby imparting them with optically active properties and rendering great superiority in the next generation of circularly polarized luminescence. However, the functionalization of chiral ligand is not fully explored and the underlying mechanism governing chirality transfer remains elusive. Herein, tryptophan (Try), a naturally occurring chiral amino acid, is verified to serve as multidentate chiral ligands attaching on the surface of perovskite NCs. Such strong coordination favors the chirality imprinting on the electronic state of CsPbBr3, resulting in notable circular dichroism features and circularly polarized luminescence with a maximum glum of 2.3 × 10−3. It is intriguing that the intermolecular interaction between Try ligands anchored on two neighboring NCs contribute to chiral optical properties as well. The RDG‐NCI analysis have confirmed the hydrogen bond between the amine and carboxylic groups on chiral Try, which may drive the chiral assembly of perovskite NCs.
RNF43 Inactivation Enhances the B‐RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells
Authors: Hsu Shih‐Han , Tsai Ya‐Li , Wang Yeng‐Tseng , Shen Che‐Hung , Hung Yu‐Hsuan , Chen Li‐Tzong , Hung Wen‐Chun 
Published: January 2024

AbstractRING finger 43 (RNF43), a RING‐type E3 ubiquitin ligase, is a key regulator of WNT signaling and is mutated in 6–10% of pancreatic tumors. However, RNF43‐mediated effects remain unclear, as only a few in vivo substrates of RNF43 are identified. Here, it is found that RNF43‐mutated pancreatic cancer cells exhibit elevated B‐RAF/MEK activity and are highly sensitive to MEK inhibitors. The depletion of RNF43 in normal pancreatic ductal cells also enhances MEK activation, suggesting that it is a physiologically regulated process. It is confirmed that RNF43 ubiquitinates B‐RAF at K499 to promote proteasome‐dependent degradation, resulting in reduced MEK activity and proliferative ability in cancer cells. In addition, phosphorylation of B‐RAF at T491 suppresses B‐RAF ubiquitination by decreasing the interaction between RNF43 and B‐RAF. Mutations at K499 in B‐RAF are identified in various cancer types. MEK and WNT inhibitors synergistically suppress the growth of RNF43‐mutated pancreatic cancer cells in vitro and in vivo. Collectively, the research reveals a novel mechanism by which RNF43 inhibits B‐RAF/MEK signaling to suppress tumor growth and provide a new strategy for the treatment of RNF43‐inactivated pancreatic cancer.
Tough Hydrogels for Load‐Bearing Applications
Authors: Petelinšek Nika , Mommer Stefan 
Published: January 2024

AbstractTough hydrogels have emerged as a promising class of materials to target load‐bearing applications, where the material has to resist multiple cycles of extreme mechanical impact. A variety of chemical interactions and network architectures are used to enhance the mechanical properties and fracture mechanics of hydrogels making them stiffer and tougher. In recent years, the mechanical properties of tough, high‐performance hydrogels have been benchmarked, however, this is often incomplete as important variables like water content are largely ignored. In this review, the aim is to clarify the reported mechanical properties of state‐of‐the‐art tough hydrogels by providing a comprehensive library of fracture and mechanical property data. First, common methods for mechanical characterization of such high‐performance hydrogels are introduced. Then, various modes of energy dissipation to obtain tough hydrogels are discussed and used to categorize the individual datasets helping to asses the material's (fracture) mechanical properties. Finally, current applications are considered, tough high‐performance hydrogels are compared with existing materials, and promising future opportunities are discussed.
Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration
Authors: Lei Miao , Liao Haitao , Wang Shijia , Zhou Hang , Zhu Jianwei , Wan Haoran , Payne Gregory F. , Liu Changsheng , Qu Xue 
Published: January 2024

AbstractBiology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition and microstructure. Here, it is reported that controlled, mild electronic inputs (<10 V; <20 min) induce a homogeneous gelatin‐chitosan mixture to undergo sorting and bottom‐up self‐assembly into a Janus film with compositional gradient (i.e., from chitosan‐enriched layer to chitosan/gelatin‐contained layer) and tunable dense‐porous gradient microstructures (e.g., porosity, pore size, and ratio of dense to porous layers). This Janus film performs is shown multiple functions for guided bone regeneration: the integration of compositional and microstructural features confers flexible mechanics, asymmetric properties for interfacial wettability, molecular transport (directional growth factor release), and cellular responses (prevents fibroblast infiltration but promotes osteoblast growth and differentiation). Overall, this work demonstrates the versatility of electrofabrication for the customized manufacturing of functional gradient soft matter.
Composite core‐double sheath fibers based on some biodegradable polyesters obtained by self‐organization during electrospinning
Authors: Kyuchyuk Selin , Paneva Dilyana , Manolova Nevena , Rashkov Iliya , Karashanova Daniela , Markova Nadya 
Published: January 2024

AbstractObtaining core‐sheath fibers by single‐spinneret electrospinning is a recent and straightforward approach to prepare composite fibers. Fibers of more complex architecture consisting of poly(ethylene oxide) (PEO) core, inner poly(l‐lactide) sheath sd and outer beeswax (BW) sheath may also be obtained using this method. In the present study we report its applicability for a large series of (bio)degradable polyesters such as poly(ε‐caprolactone), poly(d,l‐lactide‐co‐glycolide), poly(butylene succinate), poly(3‐hydroxybutyrate), and poly(l‐lactide‐co‐d,l‐lactide). The fibers have a well‐differentiated PEO core, polyester inner sheath and BW outer sheath. The possibility for targeted location of hydrophilic or hydrophobic substances in the core or in the sheaths of the PEO/polyester/BW fibers has been demonstrated using nanosized zinc oxide with unmodified (hydrophilic) or silanized (hydrophobic) surface. PEO/polyester/BW fibrous materials loaded with a model drug (5‐nitro‐8‐hydroxyquinoline) exhibit antimicrobial activity. The obtained results show that single‐spinneret electrospinning is a novel and versatile method to prepare core‐double sheath composite fibers prospective for various applications such as biomedicine, cosmetics, and food packaging.
Investigation of platelet activation and calcium store release by a topical hemostatic xerogel dressing for improved blood clotting
Authors: Patil Gokul , Pawar Rutuja , Ghormade Vandana 
Published: January 2024

AbstractAdequate topical hemostatic dressings are required as first‐line approach for reduction of uncontrolled hemorrhage, a leading cause of mortalities. Platelets play a major role during blood clotting to prevent hemorrhage during injuries. Here, we demonstrate the mechanisms activated through protease activating receptor 1 (PAR1), a platelet membrane protein in response to a porous composite xerogel dressing incorporating SiNPs (size 122 ± 10 nm) and calcium (2.5 mM), characterized by scanning electron microscopy–energy dispersive x‐ray spectroscopy and Fourier transform infrared spectroscopy. The composite displayed 13.9‐fold improved blood clotting index in comparison to commercial dressing. The composite displayed increased platelet aggregation due to development of well‐formed pseudopodia as compared to bare xerogel, SFLLRN (a thrombin mimic), adenosine di‐phosphate (a platelet activator), and heparin (a thrombin inhibitor). Further, PAR1 gene was significantly upregulated in model A549 epithelial cell line (1.2‐fold) and human platelets (1.4‐fold). The composite enhanced calcium release and its extrusion in A549 cells. Upregulation of PAR1 on the platelet surface and calcium release are crucial for platelet shape change and aggregation. The data indicate that xerogel composite containing SiNPs and calcium enhanced blood clotting through activation of PAR1. Such dressings can provide a potential hemostatic solution to reduce blood loss, disability, and mortality during surgery and trauma care.
Integral Management Zones: A novel strategy for marine bivalve production in the Gulf of California, Mexico
Authors: Soria Gaspar , Fernández‐Rivera Melo Francisco J. , Tortolini Virginia Mailen , Cinti Ana , Hernández‐Pimienta Raziel , Rocha‐Tejeda Lorena , Marinone Silvio Guido , Munguia‐Vega Adrian 
Published: January 2024

Abstract

The development of area‐based tools that combine fishing, aquaculture and repopulation practices is increasingly necessary and important to conserve ecosystems, promote sustainable use of marine resources and contribute to the well‐being of the people that rely on them.
In the Gulf of California, Mexico, two small‐scale fishers' cooperatives were granted a Permit for Exploratory Aquaculture of bivalve species, and their members decided to set three zones within those concessions: (i) a zone for natural seed collection and repopulation, (ii) a no‐take zone and (iii) an area where fishing was allowed. This management arrangement, named by them as the Integral Management Zone (Zona de Manejo Integral), was conceived as an innovative alternative to the current policy tools available in the Mexican General Law for Sustainable Fisheries and Aquaculture.
The natural collection of bivalve larvae in the artificial collectors was sufficient to allow the development of the repopulation project. Based on hydrodynamic models of larval dispersal, self‐recruitment was low, and the collection of seed depended on distant sources. The broader scale (regional) connectivity source–sink patterns should be considered in the design stages of the Integral Management Zones.
The implementation of the Integral Management Zones can complement other conservation and fisheries management tools available in Mexican environmental and fisheries laws. The approach envisioned to implement this tool is participative, with a meaningful role of local fishers in the decisions concerning the use of these zones, with a supportive engagement of governmental and other stakeholders (e.g., academia and civil society organizations).
VEXAS‐Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort
Authors: Corty Robert W. , Brogan James , Byram Kevin , Springer Jason , Grayson Peter C. , Bick Alexander G. 
Published: January 2024

ObjectiveSomatic variants in UBA1 cause VEXAS, a recently described, systemic autoinflammatory disease. Research on VEXAS has largely focused on highly symptomatic patients. We sought to determine the prevalence of canonical, VEXAS‐associated somatic variants and their disease penetrance in a diverse, unselected population.MethodsWe analyzed clinical‐grade whole genome sequencing data from 245,368 participants in the All of Us Research Program. We compared persons carrying a canonical VEXAS‐associated somatic variant to age, sex, and ancestry matched controls across the domains of diagnoses, medications, and laboratory values.Results74 participants were identified who carry one VEXAS‐defining somatic variant, UBA1 c.121A>C, p.Met41Leu. The variant allele fraction ranged from 4.5% to 33%. No other canonical VEXAS‐associated variants were identified. Of the 74 carriers, 62 (84%) were women, 20 (27%) were African American, and 14 (19%) were American Admixed/Latino. There was no statistically significant association between case/control status and any VEXAS‐associated diagnosis code, medication prescription, or laboratory value.ConclusionWe report the largest cohort to date of persons with the VEXAS‐associated p.Met41Leu somatic variant. This cohort differed substantially from reported cohorts of patients with clinical VEXAS, having a higher proportion of persons who were young, female, and of diverse ancestry. Variant allele fractions were lower than reported in clinical VEXAS cohorts, and bioinformatic analysis detected no clinical manifestations of VEXAS. Thus, the UBA1 p.Met41Leu somatic variant displayed incomplete penetrance for VEXAS. Further study is needed to determine the natural history of VEXAS‐associated somatic variants in the predisease phase.image
Biotechnological insights into extracellular enzyme production by thermotolerant fungi from hot springs and caves: Morphology, pellets formation, and protease production
Authors: Legorreta‐Castañeda Adriana Jazmín , Guerra‐Sánchez Guadalupe , García‐Gutiérrez Karina , Olicón‐Hernández Dario Rafael 
Published: January 2024

AbstractThis study investigates the thermotolerant fungal biodiversity in caves and hot springs, focusing on their potential for extracellular enzyme production, specifically proteases. Samples were collected from the Cardonal region in Hidalgo, Mexico, using three different isolation methods. The study characterizes the morphological diversity of the isolated fungi and identifies various genera, including Aspergillus, Penicillium, Trichoderma, Cladosporium, and Fusarium, based on morphology. The isolated fungi were screened for their ability to produce extracellular enzymes on solid media, with a particular emphasis on proteases due to their industrial significance. Among the 35 isolated fungi, 20 exhibited proteolytic activity, and 12 strains were identified as good protease producers based on enzymatic index values. The study also evaluated the formation of fungal pellets by proteolytic fungi and found certain strains to display significant pellet formation. Additionally, protease production was examined by fungal pellets in submerged cultures, with isolate 6 demonstrating the highest protease activity. The findings highlight the diverse thermotolerant fungal biodiversity in extreme environments, and emphasize their potential for enzymatic production. This research contributes to our understanding of fungal ecology and provides insights into the biotechnological applications of these enzymes. The study recommends further molecular investigations to enhance biodiversity studies in such extreme environments.
Finite mixtures in capture–recapture surveys for modeling residency patterns in marine wildlife populations
Authors: Caruso Gianmarco , Alaimo Di Loro Pierfrancesco , Mingione Marco , Tardella Luca , Pace Daniela Silvia , Jona Lasinio Giovanna 
Published: January 2024

AbstractThis work aims to show how prior knowledge about the structure of a heterogeneous animal population can be leveraged to improve the abundance estimation from capture–recapture survey data. We combine the Open Jolly‐Seber model with finite mixtures and propose a parsimonious specification tailored to the residency patterns of the common bottlenose dolphin. We employ a Bayesian framework for our inference, discussing the appropriate choice of priors to mitigate label‐switching and nonidentifiability issues, commonly associated with finite mixture models. We conduct a series of simulation experiments to illustrate the competitive advantage of our proposal over less specific alternatives. The proposed approach is applied to data collected on the common bottlenose dolphin population inhabiting the Tiber River estuary (Mediterranean Sea). Our results provide novel insights into this population's size and structure, shedding light on some of the ecological processes governing its dynamics.