bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammasome-targeted therapy to prevent adverse perinatal outcomes of recurrent chronic histiocytic intervillositis of unknown etiology
Authors: Lazaro Estibaliz , Mattuizzi Aurelien , Sauvestre Fanny , Fargeix Tiphaine , White Eoghann , Leibler Claire , Cargou Marine , Nathalie Dugot-Senant , Douchet Isabelle , Duluc Dorothée , Contin-Bordes Cecile , Truchetet Marie Elise , Richez Christophe , Forcade Edouard , duffau pierre , Viallard Jean Francois , Sentilhes Loïc , Blanco Patrick 
Published: November 2023

Abstract

Chronic histiocytic intervillositis of unknown origin (CHI) is a rare placental disorder associated with adverse pregnancy outcomes, frequent recurrence, and a lack of effective preventive strategies. Recent insights indicate a potential link between CHI-associated inflammatory lesions and the inflammasome pathway, suggesting innovative therapeutic avenues. This study aims to elucidate the role of the inflammasome pathway in CHI through comprehensive transcriptomic analysis of grade 2 or 3 histopathologic CHI samples, paired with placental controls. Additionally, we present case studies of three individuals with recurrent CHI who received treatment with anakinra and colchicine throughout pregnancy, resulting in improved perinatal outcomes. Notably, all cases led to the birth of healthy, full-term infants, with reduced or absent intervillositis recurrence. Placental assessment unveiled heightened activation of the NLRP3-PYCARD inflammasome pathway and IL-1β processing in CHI samples, with downregulation observed in treated pregnancy samples devoid of intervillositis. Collectively, these findings suggest a potential therapeutic role for targeting the inflammasome pathway in preventing recurrent CHI in pregnant individuals. The molecular insights provided herein open doors for innovative interventions in managing this rare placental disorder, warranting further investigation and consideration.
Reallocating Shared Groundwater Resources Using a Participatory Two-level Weighted Bankruptcy Framework
Authors: Virani Mohammad Ali Tolouei , Sabbaghian Reza Javidi , Roghani Bardia , Jovein Ehsan Bahrami , Fereshtehpour Mohammad 
Published: November 2023

Abstract

The global rising demand for exploiting limited shared groundwater resources, coupled with significant water deficit, especially in arid and semi-arid regions, has led to escalating conflicts among stakeholders. As such, using Bankruptcy Theory methods can be an appropriate response to the reallocation of resources. This study introduces a novel approach to weighted Bankruptcy, where the relative importance of stakeholders is determined by their contributions to sustainable development, and their claims’ impact on shared groundwater resources is considered. The framework is implemented in a two-level bankruptcy process including the plains and their beneficiaries (agriculture, drinking and industry). The proposed two-level weighted bankruptcy process applies to the Neyshabour-Ataiyeh-Sabzevar plains in Iran. Moreover, a Weighted Combinational Contribution-Claim (WCCC) method is proposed comparing with the other weighted methods such as Proportionality (WPRO), Constrained Equal Awards (WCEA), Pinile (WPIN), Talmud (WTAL), Constrained Equal Losses (WCEL), Modified Constrained Equal Losses (MWCEL), which are considered in two categories including the deficit-based and resource-based approaches. According to the Bankruptcy Allocation Stability Index (BASI), the preferred deficit-based method in the first reallocation level is the WCEL, while the preferred resources-based method is the WCEA. In the second reallocation level, the proposed WCCC is chosen as the preferred deficit-based method for all beneficiaries. Among the resources-based methods, the WPRO method is preferred for Neyshabour's beneficiaries. Also, the WTAL method is preferred for Sabzevar's and Ataiyeh's beneficiaries. The novel approach offers a promising solution to the water resource reallocation problem, ensuring a more equitable and sustainable management of shared groundwater resources.
WITHDRAWN: Perceived Racism and Well-Being in University Racial/Ethnic Minority Students: The Complex Roles of Racial/Ethnic Identity and Self-Esteem
Authors: Hu Yueqin , Purol Stephanie , Shen Yishan , Zheng Yao 
Published: November 2023

Abstract

Perceived racism comes in the form of blatant discrimination and microaggressions. This study investigated and compared the relations of perceived blatant discrimination and microaggression to university students’ well-being (physical and psychological health, academic adjustment), and how the associations may be influenced by racial/ethnic identity and self-esteem. A self-report survey from racial/ethnic minority university students showed that higher perceived racism was associated with higher stress levels, more somatic symptoms, and worse academic adjustment. Microaggression showed larger negative impact than blatant discrimination. Racial/ethnic identity showed complex effects—a large positive effect by promoting self-esteem and a modest negative effect by intensifying the perception of microaggression. Self-esteem was strongly associated with well-being, yet it also exacerbated the negative association between microaggression and academic adjustment. These findings suggest that racism—microaggression in particular—harm racial/ethnic minority university students in multiple aspects, and that racial/ethnic identity and self-esteem are primarily protective factors, yet mechanisms leading to negative outcomes also exist.
The correlation between Fischer’s ratio and the risk of cardiac dysfunction in Systolic Heart Failure
Authors: zhou qing fen , Yang Fan , Lu Qiu Ya , Zhang Feng Ru , Qu Bin , Lu Lin 
Published: November 2023

Abstract

Backgrounds:
Due to the high mortality and hospitalization rate in chronic heart failure (HF), it is of great significance to study myocardial nutrition conditions. Amino acids (AAs) are essential nutrient metabolites for cell development and survival. This study aims to investigate the plasma branched-chain amino acid/aromatic amino acid ratio (Fischer’s ratio, FR) as a potential metabolic risk factor for the presence of chronic HF and left ventricular (LV) pressure filling.
Methods
The value of serum AAs was obtained from 441 cardiovascular subjects by liquid chromatography-tandem, and 213 systolic HF subjects were followed up for a mean year (11.74 ± 1.44 months). LV ejection fraction (EF) and the ratio of early diastolic mitral inflow to mitral annular tissue velocities (E/e’) were determined by two-dimensional echocardiography and Doppler flow imaging using standard biplane technique. Logistic regression analysis was conducted to measure the FR index and the risk of HF, and further confirmed by receiver-operating characteristic curves (ROC curve) analysis. The event-free HF endpoint was determined by Kaplan–Meier curves, and differences were assessed using log‐rank tests.
Results
FR index decreased gradually along with the control group, systolic HF with E/e’≤14 group, and systolic HF with E/e’>14 group (3.73 ± 1.20 vs. 3.45 ± 0.94 vs. 3.18 ± 0.83, respectively, P < 0.001). Low FR index was associated with systolic HF after full adjustment in all subjects [odds ratio (OR), 2.124; 95% confidence interval (CI): 1.595–2.829; P < 0.001] and the area under the curve (AUC) of ROC curve was 0.722 (sensitivity 62.91%, specificity 78.95%). Meanwhile, low FR index was the independent risk of E/e’>14 for systolic HF (OR: 1.525; 95% CI: 1.053–2.209; P = 0.025). The AUC of ROC curve for predicting abnormal E/e’ was 0.732 (sensitivity 61.39%, specificity 75.68%) by multivariate logistic regression. Furthermore, the decreased FR values indicated poor prognosis in systolic HF subjects (Log-rank P = 0.005).
Conclusions
In all subjects, low FR confers an increased risk for predicting systolic HF. Decreased FR levels could also indicate increased LV filling pressure in systolic HF. In addition, a lower FR value was associated with higher HF endpoint events. Thus, FR can be a valuable indicator of heart function.
SemiDocSeg: Harnessing Semi-Supervised Learning for Document Layout Analysis
Authors: Banerjee Ayan , Biswas Sanket , Lladós Josep , Pal Umapada 
Published: November 2023

Abstract
Document Layout Analysis (DLA) is the process of automatically identifying and categorizing the structural components (e.g. Text, Figure, Table, etc.) within a document to extract meaningful content and establish the page's layout structure. It is a crucial stage in document parsing, contributing to their comprehension. However, traditional DLA approaches often demand a significant volume of labeled training data, and the labor-intensive task of generating high-quality annotated training data poses a substantial challenge. In order to address this challenge, we proposed a semi-supervised setting that aims to perform learning on limited annotated categories by eliminating exhaustive and expensive mask annotations. The proposed setting is expected to be generalizable to novel categories as it learns the underlying positional information through a support set and class information through Co-Occurrence that can be generalized from annotated categories to novel categories. Here, we first extract features from the input image and support set with a shared multi-scale feature acquisition backbone. Then, the extracted feature representation is fed to the transformer encoder as a query. Later on, we utilize a semantic embedding network before the decoder to capture the underlying semantic relationships and similarities between different instances, enabling the model to make accurate predictions or classifications with only a limited amount of labeled data. Extensive experimentation on competitive benchmarks like PRIMA, DocLayNet, and Historical Japanese (HJ) demonstrate that this generalized setup obtains significant performance compared to the conventional supervised approach.
Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease
Authors: Laczó Martina , Svatkova Radka , Lerch Ondrej , Martinkovic Lukas , Zuntychova Terezie , Nedelska Zuzana , Horakova Hana , Vyhnálek Martin , Hort Jakub , Laczó Jan 
Published: November 2023

Abstract

Background: Impaired spatial navigation is an early marker of Alzheimer's disease (AD), but the utility of reported navigation abilities is poorly understood. We examined the ability of self- and informant-reported spatial navigation questionnaires to discriminate between clinically and AD biomarker-defined participants from the Czech Brain Aging Study (CBAS). The associations of the questionnaires with objective measures of spatial navigation, atrophy of AD-related brain regions, AD biomarker abnormalities, and biomarker status were also examined.
Methods: In total, we recruited 262 CBAS participants, including 41 cognitively normal (CN) older adults and 221 participants from the memory clinic cohort with subjective cognitive decline (SCD, n=76), amnestic mild cognitive impairment (aMCI, n=117), and mild dementia (n=28). Participants and their informants completed three spatial navigation questionnaires. Cognitive functions, spatial navigation using real-space and computerized versions of a human analog of the Morris Water Maze, and MRI-derived volume or thickness of six AD-related brain regions were assessed. Biomarker assessment, including measurement of amyloid-β1-42, p-tau181, and total tau in cerebrospinal fluid or dual-phase amyloid PET imaging or both, was performed in a subset of the memory clinic cohort (n=137) to stratify participants by amyloid-β and AT(N) status.
Results: Informant-reported spatial navigation questionnaires distinguished participants with aMCI and mild dementia from CN participants, and amyloid-β positive aMCI participants from amyloid-β negative aMCI and CN participants. In contrast, informant-reported spatial navigation abilities were similar in amyloid-β negative aMCI and CN participants. Among participants in the memory clinic cohort (i.e., SCD, aMCI and mild dementia), informant-reported poorer spatial navigation abilities were associated with less accurate performance on real-space and computerized spatial navigation tasks, greater atrophy of the posterior hippocampus and the posteromedial entorhinal cortex, greater AD biomarker abnormalities, and amyloid-β positive status. Self-reported spatial navigation abilities were similar across all participant groups and were not associated with atrophy of AD-related brain regions, AD biomarker abnormalities, or biomarker status. Next, self—reported spatial navigation abilities were only weakly associated with objective measures of spatial navigation.
Conclusions: Informant-reported spatial navigation questionnaires may be a useful screening tool for early AD in clinical settings, reflecting atrophy of AD-related brain regions and AD pathology.
Media representation of African individuals in Australia during the COVID-19 pandemic and its impact on mental health
Authors: Akosile Wole , Tiyatiye Babangida , Bojuwoye Adebunmi , Antabe Roger 
Published: November 2023

Abstract
The COVID-19 crisis has profoundly impacted mental health globally, including in Australia. This study focuses on the media representation of Australians of African descent during the pandemic and its unintended effects on mental health. Media coverage of COVID-19 restriction breaches by individuals from African backgrounds in Australia has contributed to significant emotional and mental distress. Through content analysis of media content from popular Australian publications, we examined the prevalence of racially motivated rhetoric surrounding COVID-19 breaches within culturally and linguistically diverse communities. Our findings consistently emphasise the term "Covidiots" when reporting on COVID-19 breaches among individuals from African backgrounds. Specifically, three African girls were subjected to ongoing harassment, public shaming, and criminalization by the Australian media in relation to COVID-19 breaches, in comparison to other racial groups. These findings underscore the consistent portrayal of people from African communities as outsiders and the racial profiling they experience in media coverage of significant issues like COVID-19. Such portrayals have the potential to negatively impact mental health.
Concentration of mercury levels in saliva, milk and hair of nursing mothers in southeastern Iran
Authors: Behrooz Reza Dahmardeh , Khammar Sanaz , rajaei Fatemeh , Burger Joanna 
Published: November 2023

Abstract
This research on lactating mothers in the city of Chabahar. In this descriptive-analytical and questionnaire study, a random sample of 80 mothers were selected to examine mercury levels in their hair, milk and saliva. There was a significant correlation between mercury levels in mothers' saliva and hair, but only a weak correlation was found between mercury levels in milk and hair, and in milk and saliva. The number of children and length of mother's pregnancy were associated with the amount of mercury in mothers' milk. The number of teeth filled with amalgam of mothers, consumption of fish and marine products, consumption of fruit, and weight of the infant at birth were also associated with the amount of mercury in breast milk. Chewing gum, fish consumption, infant's birth weight, weight, and length of pregnancy were among the factors associated with the amount of mercury in mothers' saliva. The results of this study showed that although the amount of mercury in women's hair, milk and saliva is lower than the standards established by WHO and USEPA, it should be kept in mind that any amount of mercury can be harmful and there is no beneficial effect of mercury.
Feedback control of heart rate during robotics-assisted tilt table exercise in patients after stroke: a clinical feasibility study
Authors: Brockmann Lars , Saengsuwan Jittima , Schuster-Amft Corina , Hunt Kenneth 
Published: November 2023

Abstract

Background: Patients with neurological disorders including stroke use rehabilitation to improve cognitive abilities, to regain motor function and to reduce the risk of further complications. Robotics-assisted tilt table technology has been developed to provide early mobilisation and to automate therapy involving the lower limbs. The aim of this study was to evaluate the feasibility of employing a feedback control system for heart rate (HR) during robotics-assisted tilt table exercise in patients after a stroke.
Methods: This feasibility study was designed as a case series with 12 patients (n = 12) with no restriction on the time post-stroke or on the degree of poststroke impairment severity. A robotics-assisted tilt table was augmented with force sensors, a work rate estimation algorithm, and a biofeedback screen that facilitated volitional control of a target work rate. Dynamic models of HR response to changes in target work rate were estimated in system identification tests; nominal models were used to calculate the parameters of feedback controllers designed to give a specified closed-loop bandwidth; and the accuracy of HR control was assessed quantitatively in feedback control tests.
Results: Feedback control tests were successfully conducted in all 12 patients. Dynamic models of heart rate response to imposed work rate were estimated with a mean root-mean-square (RMS) model error of 2.16 beats per minute (bpm), while highly accurate feedback control of heart rate was achieved with a mean RMS tracking error (RMSE) of 2.00 bpm. Control accuracy, i.e. RMSE, was found to be strongly correlated with the magnitude of heart rate variability (HRV): patients with a low magnitude of HRV had low RMSE, i.e. more accurate HR control performance, and vice versa.
Conclusions: Feedback control of heart rate during robotics-assisted tilt table exercise was found to be feasible. Future work should investigate robustness aspects of the feedback control system. Modifications to the exercise modality, or alternative modalities, should be explored that allow higher levels of work rate and heart rate intensity to be achieved.
B7-H3 promotes the migration and invasion of colorectal cancer cells via regulating the actin cytoskeleton and RhoA/ROCK1/LIMK1 signaling pathway
Authors: Zhao Anjing , Zhu Xingchao , Wu Hongya , Wang Jiayu , Zhang Mengting , Xiang Jingrong , Xia Suhua , shi Tongguo , Xi Qinhua 
Published: November 2023

Abstract
Aberrant expression of B7 homolog 3 protein (B7-H3) has been detected in various cancers including colorectal cancer (CRC) and implicated in modulating multiple biological functions of CRC cells. However, its role in CRC metastasis has not yet been determined. In this study, we demonstrated that B7-H3 was highly expressed in CRC tissues and positively associated with poor prognosis of CRC patients. B7-H3 knockdown significantly inhibited the migration and invasion of CRC cells. B7-H3 overexpression had the opposite effect. Moreover, we determined that B7-H3 could regulate actin cytoskeleton and the RhoA/ROCK1/LIMK1 pathway. Importantly, the BDP5290, an inhibitor of the RhoA/ROCK1/LIMK1 axis, reversed the effects of B7-H3 overexpression on actin filament accumulating, migration, and invasion of CRC cells. In sum, our study concluded that B7-H3 facilitated CRC cell actin filament accumulating, migration, and invasion through the RhoA/ROCK1/LIMK1 axis.
A case report of early detection of rare femoral shaft bone metastasis in a penis cancer patient
Authors: Ajay Kumar Yadav , Sandip Kumar Mandal , Suman Gnawali , Ganga Dutta Adhikari , Nitu Sharma , Pandey Shailesh Kumar , Dhakal Deepika , Anil Pandit 
Published: November 2023

Background. Bone metastasis is very common in the advanced stage of numerous carcinomas. In penile carcinoma, lymph nodes metastasis is somehow common but it is very rare reported to be secondary from penile cancer. till the date, there are only few cases of penis carcinoma reported bone metastasis in literature worldwide.Case Presentation. Herein, We presented a 51-year-old Nepalese male with squamous cell carcinoma of penis. computed tomography (ct) scan of the patient revealed that there was carcinoma involving glans penis and precure with bilateral external & internal inguinal lymphadenopathies. After then, the patient was under gone for partial penectomy and bilateral inguinal lymphadenectomy and complete 6-cycle chemotherapy. After one year of treatment, patient developed thigh pain and headache and he advised to have magnetic Resonance imaging (mRi) of brain, 99mTc-MDP whole body bone scan and ct scan of pelvis and thigh. The examination report reveals that there was a sclerotic change in vertex of skull bone and moderate 99mTc-MDP uptake in right proximal shaft of femur just below the neck d/d metastasis. The histopathological examination of the true cut biopsy taken from the lesion of the femur showed metastatic keratinizing squamous cell carcinoma which is rare case of femoral shaft bone metastasis secondary from penile carcinoma. Then patient was sent for surgical reconstruction of femur. Based on the case studies review femur shaft bone metastasis from penile cancer is extremely rare.Conclusion. The best of our knowledge; this is the first early detected bone metastases to shaft of the femur in a patient with penile cancer. early diagnosis helps to radical treatment as well as palliative treatment. surgery is the preferred option of the treatments, especially for metastatic foci in the long bones.
Storage stability and anti-caking agents in spray-dried fruit powders: A review
Authors: Pui Liew Phing , Saleena Lejaniya Abdul Kalam , Ghazali Hasanah Mohd 
Published: November 2023

Fruit powders possess numerous benefits compared to fresh raw materials, i.e., extended shelf-life, convenient transportation and storage, a wide range of applications, etc. Nonetheless, the storage time of fruit powders depends on such factors as storage conditions, packaging, etc.
This review suggests a comprehensive analysis of articles, reviews, reports, and books indexed in Scopus, Web of Science, and eLIBRARY.RU, as well as reported at conference proceedings and other scholarly resources in 2005–2022.
Due to their high hygroscopicity, powders tend to absorb moisture from the environment and become prone to caking. Anticaking agents can prevent powders from this process. Different packaging materials also affect the compounds and properties of fruit powders. Accelerated degradation and temperature models can predict shelfp-life. This review featured the effectiveness of different anti-caking agents, as well as the impact of various packaging methods on the storage of powders. Calcium phosphate demonstrated excellent anti-caking properties, reduced hygroscopicity, and enhanced flowability. Aluminum laminated packaging proved effective in protecting powders during storage. As the storage time increased, powders demonstrated only a slight increase in moisture content. Their L* value (light to dark) and b* value (yellow to blue) decreased while the a* value (green to red) and the total color change increased. Caking increased as the flowability, pigment content, and antioxidant content went down.
The review has practical implications for developing new technologies aimed at prolonging the storage time of spray-dried fruit powders.