bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life dynamics in patients with knee osteoarthritis on intra-articular therapy with bioactive concentrate of small sea fish and domestically produced sodium hyaluronate
Authors: Sivordova L. E. , Polyakova Yu. V. , Papichev E. V. , Akhverdyan Yu. R. , Zavodovsky B. V. 
Published: January 2024

Introduction. The quality of life in patients with osteoarthritis (OA) depends on the severity of functional disorders, pain syndrome and the efficacy of their pharmacological correction.Purpose of the study. To evaluate the dynamics of the life quality in patients with knee osteoarthritis treated with intra-articular injections of domestically produced sodium hyaluronate (synovial fluid prosthesis) or with bioactive concentrate of small sea fish (BACSSF).Materials and methods. 180 patients with knee osteoarthritis were examined. The study group consisted of 50 patients who received injections of sodium hyaluronate (prosthesis synovial fluid), intra-articularly. Comparison group included 30 patients treated with BACSSF 2 ml No. 5 intraarticularly. Control group consisted of 100 patients who received BACSSF intramuscularly 1 ml No. 20. Study design: duration 12 months with prospective monitoring of quality of life according to the SF-36 scale, six visits.Results. When included in the study, the level of physical and mental health components between the groups of patients differed statistically insignificantly (p = 0.369 and p = 0.089). According to the study results, used pharmacotherapy improved quality of life in all groups. However, the groups differed statistically significantly in the speed of achieving an analgesic effect, the severity of pain reduction and the duration of maintenance of the therapy effect. The best dynamics of the physical and mental components of health was in a group of patients with knee osteoarthritis treated with intra-articular sodium hyaluronate.Conclusions. In real clinical practice, it is not always possible to improve the quality of life of patients with knee osteoarthritis. Symptomatic delayed-release medications (SYSADOA) are effective in the early stages of the disease. The positive clinical effect of intra-articular therapy with sodium hyaluronate develops earlier and lasts longer than therapy with another SYSADOA (BACSSF).
Problems of Translating annaa (أنى) in the Holy Quran
Authors: Lutfi Mona , Fareh Shehdeh , Benmessaoud Sanaa 
Published: January 2024

The present study endeavours to examine the challenges associated with translating the particle annaa from the Holy Quran into English, with a focus on three English translators of the Quran. The study identifies the multifaceted functions of annaa in Arabic grammar and its rhetorical functions within the Quranic context. Key challenges include conveying nuanced meanings, selecting appropriate modal verbs, and preserving rhetorical functions. The study emphasizes the need for a context-aware approach and the need to consult with authentic exegeses to ensure accurate and faithful translations.
Molecular Characterization and Induced Systemic Resistance of Trichoderma asperellum against Bacterial wilt of Tomato
Authors: Ahmed Tanjid , Mia Md Ratan , Aff Tawseef Al , Shila Sadia Afrin , Tanvir Md. Sohel , Sumi Subarna Mahbub , Shupta Sadia Afrin , Hossain Mohammad Delwar 
Published: January 2024

Bacterial wilt caused by Ralstonia solanacearum is one of the most devastating disease of tomato in Bangladesh and no significant effective control measure is available here till date. In this research work, Trichoderma from tomato rhizosphere is being utilized formulated with farm yard manure (FYM) to combat this pathogen attack. Ten Ralstonia spp. were also isolated from the infected tomato fields and characterised where R. solancearum isolate RsBAU1 was found most virulent, resulted 288 bp amplicon size with the species specific primers. Among 10 Trichoderma isolates, TR3 isolates (OM 480709) showed highest inhibition in vitro against R. solancearum isolate RsBAU1 that was resulted about 633 bp amplicon size with ITS primers, showed 99-100% blast homology with the other T. asperellum in phylogenic tree. T. asperellum (OM 480709) was formulated with FYM which significantly reduced and delayed Ralstonia wilt incidence and increased tomato fruit yield including other agronomic characters under both net house and field conditions. This formulated Trichoderma (FT) decreased the Ralstonia wilt disease incidence by 51.5% and increased 49.73% tomato yield when compared with the pathogen-treated plot during 2022-2023. Again, FT treated plants significantly increased peroxidase (POX), phenylalanine ammonium lyase (PAL), polyphenol oxidase (PPO), β-1,3-glucanase and total phenol activities in compared to non-treated plants and these activities were increased up to 8th days when challenged with R. solancearum (RsBAU1) and then declined. This indicates T. asperellum (OM480709) might have collectively contributed to induced resistance in tomato plants against R. solanacearum (RsBAU1 isolate). Therefore, T. asperellum (OM480709) formulated in FYM can be a sustainable and eco-friendly management strategy for controlling Ralstonia wilt of Tomato in Bangladesh.
Genomic characterization of Bacillus cereus isolated from food poisoning cases revealed the mechanism of toxin production
Authors: Zhou Qian , Li Guanqiao , Cui Yinshan , Xiang Jingshu , Zhu Shu , Li Shijun , Huang Jingyu , Wang Yafang , Liu Ying , Zhou Li 
Published: January 2024

IntroductionBacillus cereus is a ubiquitous opportunistic human pathogen that causes food intoxications worldwide. However, the genomic characteristics and pathogenic mechanisms of B. cereus are still unclear.MethodsHere, we isolated and purified nine strains of B. cereus (LY01-LY09) that caused vomiting, diarrhea and other symptoms from four foodborne outbreaks happened in Guizhou Province in southwest China from June to September 2021. After colony observation, Gram staining, microscopic examination and biochemical test, they were identified as B. cereus. The genomic characteristics, phylogenetic relationships and virulence factors of the isolated strains were analyzed at the genome level. Genome sequencing, comparative genomic analysis, secondary metabolite analysis and quantitative PCR were utilized to give a thorough exploration of the strains.ResultsWe obtained the genome maps of LY01-LY09 and found that LY01-LY09 had a complex interspecific relationship with B. anthracis and B. thuringiensis. We also observed a contraction of gene families in LY01-LY09, and the contracted families were mainly associated with prophage, which contributed to the species diversity of B. cereus. The Hsp20 gene family underwent a rapid evolution in LY01-LY09, which facilitated the adaptation of the strains to adverse environmental conditions. Moreover, the LY01-LY09 strains exhibited a higher copy number in the non-ribosomal polypeptide synthetase (NRPS) genes and carried the complete cereulide synthetase (ces) gene cluster sequences. Considering that the NRPS system is a classical regulatory mechanism for emetic toxin synthesis, we hypothesized that LY01-LY09 could synthesize emetic toxins through the regulation of ces gene clusters by the NRPS system.DiscussionThese findings are important for further investigation into the evolutionary relationship between B. cereus and their related species, as well as the underlying mechanisms governing the synthesis and secretion of bacterial toxins.
Bacterial communities during composting cultivation of oyster mushroom Pleurotus floridanus using broken eggs as the nitrogen source and study of agronomic and nutritional properties
Authors: Wei Jun , Wang Yue-Xin , Guan Ti-Kun , Wang Qiu-Ying , Zhang Jiao , Zhang Jia-Yan , Wang Jian-Li , Chen Qing-Jun , Zhang Guo-Qing 
Published: January 2024

IntroductionBroken eggs are a byproduct of the poultry industry and a potential nitrogen source for mushroom cultivation. However, its feasibility needs to be evaluated experimentally.MethodsIn this study, a series of different addition amounts (0, 1.8, 3.6, 5.3 and 8.5%, w/w) of broken egg mixture (BEM) were applied in the composting cultivation process of oyster mushroom. The physicochemical properties and bacterial communities of composting substrate, and agronomic and nutritional properties of fruiting bodies were determined.Results and discussionThe results showed that the BEM addition significantly (P &lt; 0.05) increased the total nitrogen content in the composted substrate, and the contents of crude protein, total amino acids and essential amino acids of mushrooms. The P3 treatment (initial C/N of 26:1) showed the highest biological efficiency (BE) of 100.19% and a low contamination rate (CR) of 7.00%, while the higher dosage of BEM (P4 and P5) led to a sharp decrease in BE and a sharp increase in CR. High throughput sequencing revealed that the addition of BEM significantly (P &lt; 0.05) changed the bacterial communities in the substrate at the beginning of composting. Streptococcus and Lactococcus were predominant bacterial genera in BEM treatments at the beginning stage of composting, while Acinetobacter became predominant at the ending stage. The co-occurrence network analysis showed that the P3 treatment demonstrated a much more complex bacterial community. The structural equation model analysis indicated that the addition of BEM affected the bacterial communities and nitrogen metabolism during composting, which further affected agronomic and nutritional properties of oyster mushrooms. An appropriate amount of BEM combined with composting processes can significantly improve the yield and quality of oyster mushroom, providing a new way for efficient utilization of BEM.
Exploring the short-term influence of a proprietary oil extract of black cumin (Nigella sativa) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study
Authors: Mohan M. E. , Mohan Mohind C. , Prabhakaran Prathibha , Syam Das S. , Krishnakumar I. M. , Baby Chakrapani P. S. 
Published: January 2024

BackgroundNigella sativa (black cumin, or black seed) is popularly known as the seed of blessings in the Arab system of medicine. Though not widely recommended for sleep, a unique proprietary black cumin extract (BlaQmax®/ThymoDream™; BCO-5) has been shown to be helpful in the management of stress and sleep issues.MethodsThis randomized, double-blind, placebo-controlled trial aimed to investigate the efficacy of BCO-5 on the sleep quality of volunteers characterized with a self-reported non-restorative sleep disorder. Healthy male and female participants (n = 70), aged 18-65 years (BMI 22-28 Kg/m2) were randomized to either placebo or BCO-5 (n = 35/group). Both interventions were supplemented at 200 mg/day for seven days. Actigraphy and a validated restorative sleep questionnaire (RSQ-W) were used to monitor the influence of BCO-5 on sleep.ResultsCompared to placebo, BCO-5 significantly improved sleep quality, as evidenced by both intra-group and inter-group analyses of the actigraphy data. The relative improvements observed were sleep efficiency (7.8%, p &lt; 0.001), total sleep time (19.1%, p &lt; 0.001), sleep onset latency (35.4%; p &lt; 0.001), and wake-after-sleep-onset (22.5%; p &lt; 0.001) compared with placebo. BCO-5 also improved sleep by 75.3% compared to baseline (p &lt; 0.001) and by 68.9% compared to placebo (p &lt; 0.001), when monitored by RSQ-W. BCO-5 was well-tolerated with no reports of side effects or toxicity.ConclusionBCO-5 significantly improved non-restorative sleep in seven days, indicating its potential role as a natural sleep aid.
LASSO-derived prognostic model predicts cancer-specific survival in advanced pancreatic ductal adenocarcinoma over 50 years of age: a retrospective study of SEER database research
Authors: Feng Yuan , Yang Junjun , Duan Wentao , Cai Yu , Liu Xiaohong , Peng Yong 
Published: January 2024

BackgroundThis study aimed to develop a prognostic model for patients with advanced ductal adenocarcinoma aged ≥50 years.MethodsPatient information was extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Least absolute shrinkage and selection operator (LASSO) Cox regression analysis was performed to screen the model variables. Cases from Nanchang Central Hospital were collected for external validation. The new nomogram and the American Joint Committee on Cancer (AJCC) criteria were evaluated using integrated discrimination improvement (IDI) and net reclassification index (NRI) indicators. Survival curves presented the prognosis of the new classification system and AJCC criteria.ResultsIn total, 17,621 eligible patients were included. Lasso Cox regression selected 4 variables including age, chemotherapy, radiotherapy and AJCC stage. The C-index of the training cohort was 0.721. The C-index value of the validation cohort was 0.729. The AUCs for the training cohorts at 1, 2, and 3 years were 0.749, 0.729, and 0.715, respectively. The calibration curves showed that the predicted and actual probabilities at 1, 2, and 3 years matched. External validation confirmed the model’s outstanding predictive power. Decision curve analysis indicated that the clinical benefit of the nomogram was higher than that of the AJCC staging system. The model evaluation indices preceded the AJCC staging with NRI (1-year: 0.88, 2-year: 0.94, 3-year: 0.72) and IDI (1-year: 0.24, 2-year: 0.23, 3-year: 0.22). The Kaplan–Meier curves implied that the new classification system was more capable of distinguishing between patients at different risks.ConclusionsThis study established a prognostic nomogram and risk classification system for advanced pancreatic cancer in patients aged ≥50 years to provide a practical tool for the clinical management of patients with pancreatic ductal adenocarcinoma.
Comparison between Intravitreal Bevacizumab and Triamcinolone Acetonide in Management of Diabetic Macular Edema
Authors: Siregar Simon A , Elvioza Elvioza , Victor Andi A , Djatikusumo Ari , Andayani Gitalisa A , Yudantha Anggun R 
Published: January 2024

Background: To critically evaluate the efficacy and safety profile of intravitreal bevacizumab (IVB)compared to intravitreal triamcinolone acetonide (IVTA) in patients with diabetic macular edema(DME).Methods: We searched publication related to diabetic macular edema managed by bevacizumab andtriamcinolone acteonide through systematic search of database in a period of January 2002 untilOctober 2013. Information needed from all articles were extracted into a data extraction sheet. Wereviewed the efficacy of both treatment in decreasing central macular thickness (CMT), improvementof visual acuity and the adverse effects following the injection.Results: Twelve articles were included after fulfilling inclusion and exclusion cirteria. Our analysisshowed single IVTA injection were more effective in decreasing CMT and improving visual acuity at1 week to 3 months. There were no significant improvement of CMT in multiple injection of IVTAcompared to multiple injection of IVB.Conclusion: A single intravitreal injection of IVTA appears to offer certain short-term advantagesover IVB for the management of patients with diabetic macular edema, particularly with regard toCMT.Â Keywords: intravitreal, triamcinolone acetonide, bevacizumab, diabetic macular edema
Comparison of High and Low Phacoemulsification Parameter in Safety and Patients Comfort
Authors: Putri Dian Eka , Harmani Bondan , Shidik Amir , Mansyur Muchtaruddin 
Published: January 2024

Background: To compare phacoemulsification (phaco) setting parameters with high (H) and low (L)parameters in Cipto Mangunkusumo (CM) hospitals impacted on corneal endothelial cell and patientâ€™spain perception (PP) during phaco procedure.Methods: Forty eight outpatients were eligibly selected by RCT at CM hospital in periods ofNovember 2013 to April 2014. Impacts of setting parameter difference were observed by objectivemeasurement of endothelial cell density (ECD), central corneal thickness (CCT). The PP wasmeasured by a JCI approved standard using visual analog scale (VAS) were adapted. A built-insoftware for phaco US energy count which is cumulative dissipated energy (CDE) used to objectivelytimed the phaco time, duration of operation (DO) were timed, and standard visual acuity (VA) wasalso noted. Data analysis was performed using general linear model (GLM) repeated measures.Results: Increase of CCT and decrease of ECD after 1 month in high and low phaco parameter are notsignificantly different, respectively 0.23% vs 2.23% and 8.53% vs 6.99% (p>0.05). Significantdifference were found in CDE between H and L; 15.80 vs 21.29 (p=0.015). No statistically significantdifference of VAS nor DO and VA.Conclusion: High and low parameter phacoemulsifications have an equal result in safety and patientâ€™scomfort.Â Keywords: setting phaco machine, endothelial cell density, central corneal thickness, visual analog scale
Clinical Characteristic and Microbiological Findings in Bacterial Corneal Ulcer at A Private Eye Clinic in Jakarta
Authors: Yudapratiwi Nelandriani , Lutfiamida Rifna , Soemiatno Yulinda Indarnila 
Published: January 2024

Background: Corneal ulcer is a major cause of blindness in developing countries causing prolongedmorbidity, loss of vision, and often loss of eyes. Corneal ulcer is an ocular emergency that requiresprompt and appropriate management to ensure the best visual outcome for the pattern of bacterialcorneal ulcers at a private eye clinic in Jakarta, and to test these bacteria against routinely used ocularantibiotics in order to formulate new guidelines for therapy.Methods: This was a descriptive study. All patients treated for bacterial corneal ulcers who agreed toparticipate in this study were prospectively followed. Clinical features (age, risk factors, visual acuity)and response to therapy were observed. Bacteriological profile was determined and the antibioticsusceptibility tests were done.Results: Fifteen consecutive patients with bacterial corneal ulcer (median age 39, SD 19.1) wereprospectively enrolled from September 2012 to November 2014. The predisposing factors weretrauma (40%), contact lens (33.3%), eyelid abnormalities (13.3%), and keratopathies (13.3%). Growthfrom culture was found in five patients and all of them had results of Pseudomonas sp. The isolatedPseudomonas sp was susceptible to gentamicin, levofloxacin, tobramycin, and ofloxacin. Eighty percentof patients had improved conditions with improved visual outcome.Conclusion: In this series, ocular trauma and contact lens wear were the most common predisposingfactor. Pseudomonas sp was the only microorganism isolated from the culture. The isolated bacteriawere sensitive to gentamicin, tobramycin, ofloxacin, and levofloxacin.Â Keywords: bacterial corneal ulcer, culture, corneal trauma, contact lens, antibiotic susceptibility test
Progesterone Receptor Expression in Histopathological Subtypes of Beningn Orbitocranial Meningiomas
Authors: Lassie Naima , Supartoto Agus 
Published: January 2024

Background: Meningioma is the most common benign brain tumor which has several subtypes histopathologically.Previous studies indicate that progesterone receptors (PR) plays important role in thetumor behavior and may determine its prognosis. However, whether different subtypes show similarPR expression remains unclear. This study aimed to evaluate PR expression, in many histopathologicalsubtypes of benign orbitocranial meningiomas.Methods: Eighty one patients visiting Sardjito General Hospital with benign orbitorcranial meningioma(WHO grade I) between 2010-2013 were included. Tumor specimens were obtained for histopathologyassessment and PR expression using immunohistochemistry examination, including the intensity ofexpression.Results: There were 72 (88.9%) women and 9 (22.2%) men, aged between 21-72 years old. PR waspositive in 71.6% patients (76.4% women). There were different subtypes of meningioma as follows:meningotheliomatous (44.4%), transitional (33.3%), and fibrous (14.8%). PR was positive in 72.2%meningotheliomatous, 70.4% in transitional, and 66.7% fibrous subtype. Other subtypes of benignmeningioma (microcystic, angiomatous, lymphoplamocyte-rich, and metaplastic) were not found inour study. But, this finding was not statistically significant using Pearson correlation test (p>0.05).Conclusion: The majority of patients with meningioma were women. The most common histopathologicalsubtypes were meningotheliomatous and transitional, of which more than 70% was PR positive.However, there were very little variations in PR expression among different subtypes of benign orbitocranialmeningioma.Â Keywords: orbitocranial meningioma, progesterone receptor (PR) expression, histopathological subtype
Devastating Lower Eyelid Squamous Cell Carcinoma in Patient with Xeroderma Pigmentosum
Authors: Rahayu Novia , Anggraini Neni , Andrisa Rossalyn Sandra 
Published: January 2024

Background: Xeroderma pigmentosum (XP), an inherited condition of cellular sensitivity to ultraviolet (UV) radiation, mainly presents as cutaneous and ocular abnormalities, including neoplasia. This report aimed to demonstrate a devastating case of lower eyelid squamous cell carcinoma in XP patient.Case Illustration: Twenty four-year-old female with XP came with white plaque on both cornea. Excisional biopsy revealed a conjunctival intraepithelial neoplasia DD/ carcinoma in situ on right eye, and hyperplastic squamous epithelia on left eye. For nearly two years, she was lost to follow up, and revisited our clinic with a rapid growing, ulcerated, susceptible to bleed, red-yellowish mass, expanding to bulbar and tarsal conjunctiva, about 27 x 15 x 10 mm size, on her lower left eyelid, with restricted ocular movement. Incisional biopsy revealed a well-differentiated squamous cell carcinoma. In 6 weeks time, mass has grown to size 75 x 50 x 20 mm, and already infiltrated to superior eyelid and orbit.Conclusion: The nature of malignancy in XP patient is exceptionally progressive. Thorough education, close monitoring and early treatment is critical to prevent rapid deterioration and minimize possible impairment caused. Â Keywords: xeroderma pigmentosum, squamous cell carcinoma, eyelid squamous cell carcinoma, squamous cell carcinoma treatment
Preparing A Seismic Database for Nineveh Governorate Using Modern Technologies
Authors: Hamdom Alaa N. , Thanoon Rayan G. , Qubaa Abdalrahman , Ali Sabah H. 
Published: January 2024

Seismic activity has become noticeable in the areas adjacent to the seismic belt within the creeping Zagros range, a large earthquake occurred and was followed by aftershocks. This needs to update seismic data for areas near the Zagros range. This study aimed to prepare an integrated database of seismic activity for Nineveh Governorate, due to the importance of seismic information and the seismic code in the process of urban expansion and development in the governorate, as well as the importance in terms of monitoring and reducing natural disasters. This study included updating seismic information by reviewing the seismic archive and seismic data for the governorate, relying on several sources (research studies, seismic data, and earthquakes from multiple global observatories such as USGS, GFZ, and EMSC), in order to be published and distributed spatially on a basic map, and then preparing Peak ground acceleration map for the governorate. As a final result of this study, it was found that there is an increase in seismic events in Nineveh Governorate, which are closely linked to the main fault system present in the geological map, and the seismic map of Nineveh Governorate has been