bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum metabolomics of treatment response in myasthenia gravis
Authors: Sikorski Patricia , Li Yaoxiang , Cheema Mehar , Wolfe Gil I. , Kusner Linda L. , Aban Inmaculada , Kaminski Henry J. 
Published: October 2023

Objective
High-dose prednisone use, lasting several months or longer, is the primary initial therapy for myasthenia gravis (MG). Upwards of a third of patients do not respond to treatment. Currently no biomarkers can predict clinical responsiveness to corticosteroid treatment. We conducted a discovery-based study to identify treatment responsive biomarkers in MG using sera obtained at study entry to the thymectomy clinical trial (MGTX), an NIH-sponsored randomized, controlled study of thymectomy plus prednisone versus prednisone alone.

Methods
We applied ultra-performance liquid chromatography coupled with electro-spray quadrupole time of flight mass spectrometry to obtain comparative serum metabolomic and lipidomic profiles at study entry to correlate with treatment response at 6 months. Treatment response was assessed using validated outcome measures of minimal manifestation status (MMS), MG-Activities of Daily Living (MG-ADL), Quantitative MG (QMG) score, or a strictly defined composite measure of response.

Results
Increased serum levels of phospholipids were associated with treatment response as assessed by QMG, MMS, and the Responders classification, but all measures showed limited overlap in metabolomic profiles, in particular the MG-ADL. A panel including histidine, free fatty acid (13:0), γ-cholestenol and guanosine was highly predictive of the strictly defined treatment response measure. The AUC in Responders’ prediction for these markers was 0.90 irrespective of gender, age, thymectomy or baseline prednisone use. Pathway analysis suggests that xenobiotic metabolism could play a major role in treatment resistance. There was no association with outcome and gender, age, thymectomy or baseline prednisone use.

Interpretation
We have defined a metabolomic and lipidomic profile that can now undergo validation as a treatment predictive marker for MG patients undergoing corticosteroid therapy. Metabolomic profiles of outcome measures had limited overlap consistent with their assessing distinct aspects of treatment response and supporting unique biological underpinning for each outcome measure. Interindividual variation in prednisone metabolism may be a determinate of how well patients respond to treatment.
Influence of pharmacogenetics on the diversity of response to statins associated with adverse drug reactions
Authors: Sainz de Medrano Sainz Jaime I. , Brunet Serra Mercè 
Published: October 2023

Abstract

Background
Statins are one of the most prescribed medications in developed countries as the treatment of choice for reducing cholesterol and preventing cardiovascular diseases. However, a large proportion of patients experience adverse drug reactions, especially myotoxicity. Among the factors that influence the diversity of response, pharmacogenetics emerges as a relevant factor of influence in inter-individual differences in response to statins and can be useful in the prevention of adverse drug effects.

Content
A systematic review was performed of current knowledge of the influence of pharmacogenetics on the occurrence and prevention of statin-associated adverse reactions and clinical benefits of preemptive pharmacogenetics testing.

Summary
Genetic variants SLCO1B1 (rs4149056) for all statins; ABCG2 (rs2231142) for rosuvastatin; or CYP2C9 (rs1799853 and rs1057910) for fluvastatin are associated with an increase in muscle-related adverse effects and poor treatment adherence. Besides, various inhibitors of these transporters and biotransformation enzymes increase the systemic exposure of statins, thereby favoring the occurrence of adverse drug reactions.

Outlook
The clinical preemptive testing of this pharmacogenetic panel would largely prevent the incidence of adverse drug reactions. Standardized methods should be used for the identification of adverse effects and the performance and interpretation of genotyping test results. Standardization would allow to obtain more conclusive results about the association between SLCO1B1, ABCG and CYP2C9 variants and the occurrence of adverse drug reactions. As a result, more personalized recommendations could be established for each statin.
Subverting motion in science fiction? Beam in the Star Trek TV series
Authors: Törmä Kajsa 
Published: October 2023

Abstract
Characters in science fiction TV have to move through the universe at the speed which the plot necessitates. In Star Trek, characters can beam from one location to another in an instant. In the visual modality, there is no continuous path of motion between the source and the goal, which would technically disqualify beam from most linguistic definitions of motion. This study aims to map out the usage patterns of beam and investigate whether or not it is linguistically construed as motion within the show. The study is based on a section of the TV Corpus (Davies, Mark. 2019. The TV Corpus. https://www.english-corpora.org/tv/ (accessed 28 May 2022)) consisting of all available episodes of all Star Trek TV series between 1966 and 2005 and uses a combination of quantitative and qualitative methods. The study found that beam is indeed used as a motion verb within the series. Its usage is also quite varied, denoting motion of many different figures in many different directions. The fact that we conceive of beaming as motion even though there is no continuous path might be partly explained by the etymology of beam, and partly by the embodied nature of language. Our current register makes it is hard to imagine transportation without movement.
Crystal structure of 1,4-dibromo-2,5-bis(2-methoxyethoxy)benzene-1,4-diol, C12H16Br2O4
Authors: Wang Zhi-Yong , Lu Wan-Li , Zhou Xu , Yang Xian-Jiong , Zhang Qi-Long , Xu Hong 
Published: October 2023

Abstract
C12H16Br2O4, monoclinic, P21/n (no. 14), a = 12.594(5) Å, b = 4.4613(16) Å, c = 12.878(4) Å, β = 91.209(12)∘, V = 723.4(4) Å3, Z = 2, R
gt(F) = 0.0450, wR
ref(F
2) = 0.1103, T = 293 (2) K.
Countermovement Jump Force-Time Curve Analyses: Reliability and Comparability Across Force Plate Systems
Authors: Merrigan Justin J. , Strang Adam , Eckerle Jason , Mackowski Nick , Hierholzer Kaela , Ray Nicole T. , Smith Roger , Hagen Joshua A. , Briggs Robert A. 
Published: October 2023

Abstract
Merrigan, JJ, Strang, A, Eckerle, J, Mackowski, N, Hierholzer, K, Ray, NT, Smith, R, Hagen, JA, and Briggs, RA. Countermovement jump force-time curve analyses: reliability and comparability across force plate systems. J Strength Cond Res 38(1): 30–37, 2024—Considering the growing prevalence of commercial force plates providing automated force-time analyses, understanding levels of agreement across force plate systems is warranted. Countermovement jump (CMJ) metrics across Vald ForceDecks (FD), Hawkin Dynamics (HD), and Sparta Science (SS) force plate systems were compared. Twenty-two subjects completed CMJ testing (∼128 comparisons) on each force plate system separately with rest between jumps. Baseline testing occurred 3 times and demonstrated poor test-retest reliability for modified reactive strength index (mRSI) and rate of force development (RFD). ForceDecks and HD comparisons yielded acceptable agreement for concentric/propulsive relative force and net impulse, jump height, eccentric/braking RFD, and mRSI, but systematic and proportionate bias existed for RFD. Sparta Science jump height and reactive strength index (RSI) demonstrated systematic overestimations compared with HD and FD, but jump height had acceptable agreement according to concordance correlation coefficients (CCC = 0.92–0.95). Agreement between SS load (eccentric RFD) and HD braking RFD was acceptable (CCC = 0.91), whereas agreement between SS load and FD deceleration RFD was considered acceptable (CCC = 0.81–0.87) but demonstrated systematic and proportionate bias. ForceDecks (CCC = 0.89) and HD (CCC = 0.85) average relative concentric/propulsive force yielded acceptable agreement with SS explode (average relative concentric force), but SS explode demonstrated systematically lower values than FD and HD. Sparta Science drive (concentric impulse) yielded acceptable agreement with HD relative propulsive impulse (CCC = 0.85), but not FD concentric impulse. Human performance practitioners need to be aware of inconsistencies among testing procedures and analyses across force plate systems, such as differences in metric definitions and units of measurement, before making comparisons across systems.
Effect of Extreme Volume-Load Differences for a Single Unilateral Exercise During In-Season Resistance Training on Measures of Bilateral Strength, Power, and Speed in Collegiate American Football Players
Authors: Crawley Katie , Adams Kent J. , DeBeliso Mark , Lawrence Marcus M. 
Published: October 2023

Abstract
Crawley, K, Adams, KJ, DeBeliso, M, and Lawrence, MM. Effect of Extreme Volume-Load Differences for a Single Unilateral Exercise During In-Season Resistance Training on Measures of Bilateral Strength, Power, and Speed in Collegiate American Football Players. J Strength Cond Res XX(X): 000–000, 2023—This study examined the impact extreme volume-load differences for a single weekly exercise, when all other exercises' volume loads were similar, would have on American football performance variables after in-season resistance training (RT). Twenty male National Collegiate Athletic Association (NCAA) American footballers (18–23 years, 98.4 ± 19.3 kg) were randomly assigned to an extreme high-volume low-intensity (EHVLI; n = 11) group or a low-volume high-intensity (LVHI; n = 9) group. Subjects performed the same evidence-based RT exercises and volume loads for 8 weeks thrice weekly, with the only differences being once weekly unilateral reverse dumbbell lunge (EHVLI) or unilateral Hatfield safety bar back squat (LVHI) exercises performed with different volume loads. Performance variables were assessed 1 week before (PRE) and after (POST) 8 weeks of RT. A 2-way analysis of variance with repeated measures and the Sidak post hoc test were used (p < 0.05). Extreme high-volume low-intensity had no significant (p > 0.05) PRE-to-POST RT changes in muscular strength in 1 repetition maximum (251.8 ± 48.7 to 274.6 ± 61.3 kg) or power in vertical jump (79.2 ± 8.8 to 78.2 ± 10.8 cm). Conversely, LVHI had significant (p < 0.05) PRE-to-POST RT improvements in strength (249.2 ± 54.4 to 284.1 ± 55.0 kg) and power (72.8 ± 11.4 to 76.3 ± 10.0 cm). Furthermore, LVHI vs. EHVLI displayed significantly greater percentage difference increases from PRE values in muscular power (6.7% ± 7.2 vs. −1.3% ± 6.0, respectively), with no significant differences between groups (LVHI vs. EHVLI) in muscular strength (8.8% ± 3.1 vs. 6.7% ± 8.0, respectively) and 10-yard acceleration (2.2% ± 5.6 vs. 3.2% ± 5.6, respectively). For in-season RT of strength and power in collegiate American football players, all exercises performed should use evidence-based volume loads to optimize adaptations because a single exercise performed with extreme volume load may limit muscular strength and power development.
‘A glimmer of hope’: perceptions, barriers, and drivers for medicinal cannabis use amongst Australian and New Zealand people with endometriosis – a qualitative study
Authors: Sinclair Justin , Abbott Jason , Mikocka-Walus Antonina , Ng Cecilia , Sarris Jerome , Evans Subhadra , Armour Mike 
Published: October 2023

Previous quantitative research has shown that cannabis use, mostly illicit, is used for symptom management amongst those with endometriosis living in Australia or New Zealand, but the drivers and barriers for use of legal, medicinal cannabis in this population are currently unclear. This study sought to investigate, via online focus groups, the perceptions, barriers, drivers, and experiences associated with cannabis use, whether legal or illicit, amongst 37 Australians and New Zealanders, aged 18–55, with a medical diagnosis of endometriosis. Previous cannabis usage was not required to participate. Discussion topics included strategies employed to manage symptoms, exploration of current medications, previous use of cannabis for pain management, and interest in using medicinal cannabis as a management strategy. Participants with moderate-to-severe symptoms of medically diagnosed endometriosis reported inadequacies with their current medical and self-management strategies and were inclined to try medicinal cannabis, both as part of their medical management and as part of a clinical trial. Barriers to medicinal cannabis adoption identified in this cohort included high costs of legal cannabis products, lack of clarity and fairness in current roadside drug testing laws and workplace drug testing policies, concern over the impact of stigma affecting familial, social and workplace life domains, and subsequent judgement and the lack of education/engagement from their medical providers regarding cannabis use. Given the interest in medicinal cannabis and the reported lack of effective symptom management, clinical trials are urgently required to determine the potential role that medicinal cannabis may play in reducing the symptoms of endometriosis.

Lay summary
Previous research has demonstrated that cannabis, either medically or illicitly obtained, is being used to manage the pain and associated symptoms of endometriosis in people across Australia and New Zealand. However, there are no clinical trials yet to determine how safe and effective medicinal cannabis might be for endometriosis symptoms. Before we design our clinical trial we wanted to get input from people in the community who have endometriosis to understand what kind of barriers there might be to both being in a clinical trial and using medicinal cannabis for their symptoms. Overall, the vast majority of participants were open to trying medicinal cannabis as a management option, driven mainly by inadequacies in their current medical and self-management strategies. Several barriers to adoption were identified, including the high costs of legal cannabis products, current drug driving laws or workplace drug testing policies, and the negative stigma around cannabis usage.
Menumbuhkan Literasi Anak Melalui Taman Bacaan Masyarakat Himpunan Mahasiswa Prodi Ilmu Perpustakaan dan Informasi Islam IAIN Curup
Authors: Marleni Marleni , Murdani Hati 
Published: October 2023

Perguruan tinggi memegang peranan dalam menumbuhkan literasi pada masyarakat sesuai dengan tri dharma yang ada. Dalam hal ini salah satunya adalah kemampuan baca tulis masyarakat. Tumbuhnya kebiasaan membaca terkhususnya pada anak dapat mendorong peningkatan kualitas hidup masyarakat. Tulisan ini mengkaji bagaimana membangun dan menumbuhkan literasi anak berdasarkan pengalaman program Taman Bacaan Masyarakat oleh Himpunan Mahasiswa Prodi Ilmu Perpustakaan IAIN Curup. Penelitian ini bertujuan untuk mengetahui peran Himpunan Mahasiswa Prodi Ilmu Perpustakaan dalam menumbuhkan literasi anak . Metode penelitian yang digunakan yaitu metode penelitian kualitatif deskriptif. Hasil penelitian ini diperoleh bahwa Taman Bacaan Masyarakat ini dibangun oleh Himpunan Mahasiswa Prodi Ilmu Perpustakaan IAIN Curup berlokasi di Kabupaten Rejang lebong, Bengkulu dimulai sejak tahun 2021, untuk memeberikan kesadaran kepada anak-anak mengenai literasi dengan cara memberikan edukasi diberbagai bidang ilmu yang diberikan langsung oleh pelaksana Taman Bacaan Masyarakat dengan ini peranan Taman Bacaan benar-benar dapat memperkuat pengetahuan anak-anak bahkan masyarakat di kabupaten Rejang Lebong.
Peranan Perpustakaan Terhadap Pentingnya Pembinaan dan Peningkatan Minat Baca
Authors: Makdis Nasrul , Jendri Jendri 
Published: October 2023

Tulisan ini bertujuan untuk menjelaskan secara konferehensif terhadap peranan kepustakaan terhadap pembinaan minat baca yang sesuai dengan prinsip-prinsip yang telah ditentukan. Yang nantinya bisa diterapkan secara operasional dan bahkan menumbuhkan minat baca secara signifikansi. Penelitian ini menggunakan penelitian kualitatif yang bersifat studi kepustakaan (library research) yang menggunakan buku-buku atau literatur yang berhubungan dengan penelitian ini untuk dijadikan sebagai objek utama penalitian, yang kemudia dianalisis secara deskriptif induktif untuk memberikan sebuah gambaran dengan jelas, objektifitas, dan sitematismengenai peranan kepustakaan terhadap pembinaan minat baca. Dari hasil pembahasan penelitian ini menunjukan bahwa, kurangnya maraknya ditemukan di kalangan masyarakat dalam minat baca bahkan masyarakat tidak mau membaca dan mencari informasi mengenai sesuatu, padahal dengan perkembangan teknologi mudahnya untuk mengakses bahan bacaan deberbagai tempat misalnya diperpustakaan supaya menjadikan masyarakat yang cerdas dalam perihal membaca. Namun hal in memiliki faktor secara internal maupun eksternal, atau disebut juga dengan istilah tranpormatif.
Pemetaan Subyek Penelitian Pada Skripsi Mahasiswa Fakultas Kedoteran UIN Syarif Hidayatullah Jakarta
Authors: Lolytasari Lolytasari , Hayati Nurul 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pemetaan subyek skripsi mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kuantitatif. Populasi dalam penelitian ini adalah skripsi mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta tahun 2019 - 2022 yang berjumlah 343 judul skripsi. Keseluruhan populasi tersebut diambil sebagai sampel penelitian. Hasil penelitian ini menunjukkan bahwa keragaman subjek dari skripsi yang telah dihasilkan mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta sebanyak 27 subyek. Dari 27 subyek tersebut, diketahui bahwa subyek yang paling banyak diteliti oleh mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta adalah penyakit yaitu sebesar 37 % (126 judul skripsi); subyek yang paling sedikit diteliti adalah anatomi, sitologi, histologi manusia, Kedokteran forensik; insidensi cedera, luka, penyakit, kedokteran preventif publik, Bedah, kedokteran, Ginekologi, obstetrik, pediatrik, geriatrik yaitu masing-masing sebesar 3 % (masing-masng 10 Judul skripsi), serta Kedokteran dan Kesehatan sebesar 2% (6 judul skripsi). Sementara itu, tidak ada subyek di dalam bagan Dewey Decimal Classification (DDC) yang belum pernah diteliti oleh mahasiswa Fakultas Kedokteran UIN Syarif Hidayatullah Jakarta.
Perkembangan Publikasi UIN Syarif Hidayatullah Jakarta Terindeks Scopus Tahun 2019-2021
Authors: Andayani Ulpah 
Published: October 2023

Salah satu tugas utama perguruan tinggi adalah mengembangkan dan menyebarluaskan ilmu pengetahuan yang dihasilkan melalui kegiatan riset. Hasil-hasil riset karenanya harus dipublikasikan melalui saluran-saluran komunikasi ilmiah yang dapat diakses oleh masyarakat luas. Tulisan ini bertujuan melakukan evaluasi terhadap publikasi internasional UIN Syarif Hidayatullah Jakarta terindeks Scopus pada periode 2019-2021. Dengan menggunakan metode kuantitatf, publikasi dosen UIN Syarif Hidayatullah dipetakan berdasarkan tingkat produktifitas publikasi dan sitasi yang dihasilkan. Hasil penelitian menunjukkan bahwa telah terjadi peningkatan jumlah publikasi internasional terindek Scopus pada kurun waktu tiga tahun sebanyak 205 publikasi dengan 580 sitasi yang menunjukan adanya keseriusan Lembaga untuk menjadi salah satu universitas berkelas dunia.
Molecular characteristics of carbapenem-resistant Raoultella ornithinolytica
Authors: Sun Xicai , Wang Yugang , Wang Xuesong , Wang Honggang 
Published: October 2023

AbstractAim of this study was to explore molecular characteristics and resistance mechanisms of carbapenem-resistant Raoultella ornithinolytica (CR-ROR) isolated from patients in a hospital in China. Three CR-ROR strains were collected and bacterial identification was done by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) Vitek-MS and by digital DDH analysis. VITEK 2 compact system and Kirby-Bauer (K–B) disk diffusion were used for antimicrobial susceptibility testing. Whole genome sequencing was carried out using the Illumina platform NovaSeq sequencer. Abricate software was used for the prediction of antibiotic resistance genes of three CR-ROR strains. The phylogenetic tree was constructed through genome SNPs to investigate the genetic relationship of three CR-ROR strains. Three CR-ROR (WF1357, WF2441, and WF3367) strains were collected in this study. Two strains were isolated from neurosurgery (WF1357 and WF2441), and one was isolated from pulmonology department (WF3367). All strains harboured multiple antibiotic resistance genes. Two strains (WF1357, WF2441) carried the blaNDM-1 gene, one of the strains (WF3367) carried the blaKPC-2 gene. Three CR-RORs were resistant to different antimicrobial agents including carbapenems. The three CR-ROR strains collected in this study and 51 CR-ROR strain genomes downloaded from NCBI, were divided into six evolutionary groups (A-F). In this study, three CR-ROR strains were found to have a higher level of resistance to antibacterial agents and carried multiple antibiotic resistance genes. The CR-ROR strains carrying multiple antibacterial resistant genes require the stringent monitoring to avoid the spread of multidrug-resistant bacterial strains.
Extended state observer design for uncertainty estimation in electronic throttle valve system
Authors: Mahmood Noor S. , Humaidi Amjad J. , Al-Azzawi Raaed S. , Al-Jodah Ammar 
Published: October 2023

AbstractThe Electronic Throttle Valve (ETV) is the core part of automotive engines which are recently used in control-by-wire cars. The estimation of its states and uncertainty is instructive for control applications. This study presents the design of Extended State Observer (ESO) for estimating the states and uncertainties of Electronic Throttle Valve (ETV). Two versions of ESOs have been proposed for estimation: Linear ESO (LESO) and Nonlinear ESO (NESO). The model of ETV is firstly developed and extended in state variable form such that the extended state stands for the uncertainty in system parameters. The design of both structures of ESOs are developed and a comparison study has been conducted to show the effectiveness of the proposed observers. Numerical simulation has been conducted to assess the performance of observers in estimating the states and uncertainties of ETV. The simulated results showed that both full order and reduced order models of ETV have the same transient characteristics. Moreover, the effectiveness of two versions of observers has been examined based on Root Mean Square of Error (RMSE) indicator. The results showed that the NESO has less estimation errors for both states and uncertainties than LESO.