bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВИВЧЕННЯ ПРОДУКТИВНОСТІ ВИРОЩУВАННЯ ГРИБІВ Pleurotus ostreatus НА ВІДПРАЦЬОВАНІЙ КАВОВІЙ ГУЩІ, ОБРОБЛЕНІЙ ЕКСТРАКТОМ ЛЮЦЕРНИ
Authors: Макас Антоніна , Крусир Галина , Брайтенмозер Лена , Хугі Хрістоф , Пилипенко Людмила , Севастьянова Олена , Здорик Олександр , Мальований Мирослав 
Published: February 2024

Метою дослідження була оцінка можливостей використання кавової гущі (ГК) для виробництва поживних грибів роду Pleurotus ostreatus та білкової добавки до щоденного раціону сільськогосподарських тварин, а також впливу екстракту люцерни на основні показники вирощування грибів. Було досліджено шість різних формул субстрату кавовий шлам (КШ)/пшенична солома з вмістом КШ: 100 %, 80 %, 70 %, 60 %, 50 % і 0 % хімічними та фізіко-хімічними методами. На субстратах з вищим вмістом КГ швидкість росту міцелію та зага-льний час колонізації були довшими і зростали зі збільшенням вмісту КГ. Додавання КГ не мало значного впливу на склад грибів Pleurotus ostreatus. Обробка субстратів екстрактом люцерни прискорювала період ко-лонізації на 2–3.1 доби, а активація стадій повної колонізації субстрату міцелієм після обробки екстрактом люцерни становила 14.96–26.56 %. Високий вміст КГ у субстраті призводить до зниження біологічної ефективності та врожайності, а обробка субстратів екстрактом люцерни підвищує біологічну врожайність, економічну врожайність та біологічну ефективність. Поживна цінність грибів була покращена переважно на субстратах з 50 % вмістом КГ порівняно з плодами, вирощеними на субстратах без кавового шламу.
IMPACTO DE LA UTILIZACIÓN DEL MONITOR AMBULATORIO DE LA PRESIÓN ARTERIAL EN LOS PACIENTES DE UN PROGRAMA DE SEGUIMIENTO FARMACOTERAPÉUTICO
Authors: Rivas Solano Luis-Manuel , Sánchez Araya José-Miguel , Cordero García Eugenia , Chaverri Fernández José-Miguel 
Published: February 2024

El objetivo de este estudio es analizar el impacto de un monitor ambulatorio de presión arterial (M.A.P.A.) en el control de los pacientes hipertensos del programa de seguimiento farmacoterapéutico de una clínica de atención primaria. En cuanto a la metodología del presente trabajo, se lleva a cabo un estudio observacional prospectivo con los pacientes hipertensos que fueron referidos desde mayo de 2018 hasta febrero de 2019, donde los valores de presión arterial se comprobaron con el M.A.P.A. Asimismo, el impacto del programa de seguimiento farmacoterapéutico se analiza por medio del valor de presión arterial, frecuencia cardiaca, presión arterial media, índice de masa corporal (IMC) y nivel de creatinina, así como la adherencia al tratamiento antes y después de ser parte del programa de seguimiento farmacoterapéutico a través del análisis con t-Student. En relación con los resultados, se incluyen a 30 pacientes, de los cuales el 40 % presentaban la presión arterial normal u óptima al realizarse el mapeo con M.A.P.A. Por este motivo, se incluyeron a 18 pacientes (60 %) para el seguimiento farmacoterapéutico. Se identificaron 283 resultados negativos asociados a la medicación, 171 problemas relacionados con los medicamentos y un 11 % de adherencia al tratamiento; posterior a las intervenciones realizadas se logró un 100 % de adherencia al tratamiento. En conclusión, la utilización de un monitor ambulatorio de presión arterial (M.A.P.A.) permite identificar pacientes con hipertensión descontrolada y realizar intervenciones farmacéuticas adecuadas, con el fin de evitar la prescripción de medicamentos innecesarios y de aumentar la adherencia al tratamiento.
Palabras clave: Hipertensión, Educación en Farmacia, Servicios Farmacéuticos, Cumplimiento y adherencia al tratamiento. Fuente: DeCS/MeSH.
CONSULTAS SOBRE ALÉRGENOS EN MEDICAMENTOS: EXPERIENCIA DESDE EL CENTRO NACIONAL DE INFORMACIÓN DE MEDICAMENTOS DE COSTA RICA
Authors: Bonilla-Acosta María Laura , Cruz-González Tatiana , Fernández-Jiménez Alejandra , Hall-Ramírez Victoria , Hidalgo-Rivera Mónika , Kenton-Paniagua Karen , Pereira-Céspedes Alfonso , Villalobos-González Cristy , Villalobos-Rojas Sebastián , Rocha-Palma Milania 
Published: February 2024

Actualmente en Costa Rica, el acceso a la información sobre contenido de gluten, lactosa y otros alérgenos en medicamentos es limitada, lo que dificulta el uso seguro de éstos por parte de las personas con condiciones de salud asociadas a estas sustancias. La presente investigación tuvo el objetivo de promover el conocimiento sobre la presencia de gluten, lactosa y otros alérgenos en los medicamentos en Costa Rica, así como describir las intervenciones farmacéuticas requeridas en la atención de las ya mencionadas personas, mediante el análisis de las consultas relacionadas con este tema presentadas al Centro Nacional de Información de Medicamentos (CIMED), lo cual no había sido previamente reportado en nuestro país. Se tomaron en cuenta las 182 consultas sobre la presencia de gluten y otros alérgenos en medicamentos que se realizaron al CIMED entre febrero de 2021 y marzo de 2022 y cuya información quedó registrada en la base de datos interna del Centro. Los resultados indican que la presencia de gluten en los medicamentos registrados fue muy baja; sin embargo, en el 40% de los medicamentos en los que la información sobre la lactosa estaba disponible resultaron positivas. Asimismo, se consideró oportuno implementar intervenciones de atención farmacéutica en muchos casos, entre las cuales destacó la educación sanitaria. Como conclusión, las personas con condiciones de salud vinculadas con gluten, lactosa y otros alérgenos evidencian una clara necesidad de fuentes de información veraz sobre su contenido en medicamentos, por lo que es necesario incorporar en la normativa de su etiquetado la declaración de contenido de excipientes alérgenos utilizados en la fabricación, así como fortalecer las labores de atención farmacéutica que favorecen, entre otros beneficios, un uso más seguro de sus medicamentos.
Palabras clave: Medicamentos, Preparaciones Farmacéuticas, Alérgenos, Información. Fuente: DeCS/BIREME
POLYSEMY IN FROZEN (2013) MOVIE
Authors: Darojatun Desri Utari , Nurhapitudin Irman , Sulaeman Dedi 
Published: February 2024

Objectives of this study were to analyze types of polysemy in the and to interpret polysemous words realized in the Frozen movie script. A method of this study was qualitative that produced descriptive data. The data were words that contained polysemy. A source of data in the study was Frozen (2013) movie scripts. The data were analyzed using suitable theories, including the type of polysemy proposed by Apresjan (1974) and meaning proposed by Lyons (1981). Based on the analysis, it was found that there are 26 pairs of data of polysemy that consist of two types of polysemy; 20 pairs of data are regular polysemy and six pairs of data were irregular polysemy. In the Frozen movie script, regular polysemy is more dominant than irregular polysemy because regular polysemy has the same systematic word but is different semantically or non-synonymous. Meanwhile, irregular polysemy has the same or true meaning as other words, and even it has no systematic relation. In conclusion, polysemy can arise in spoken or written language, so that the ambiguous word that have more than one meaning are categorized into polysemy. Keywords: polysemy, meaning, frozen, movie script, semantics
ANALISIS KEBUTUHAN PELATIHAN KETERAMPILAN ABACUS ARITMATIKA BAGI GURU MADRASAH
Authors: Elice Deti , Pahrudin Agus , Syafril Syafrimen , Koderi Koderi , Patimah Siti 
Published: February 2024

This research aims to analyze the training needs for arithmetic abacus skills, particularly among teachers at Madrasah Ibtidaiyah Bandar Lampung. The focus is on minimizing errors and failures in achieving expected goals, as well as addressing training outcomes that do not align with the participants' objectives and needs. Through the analysis of training needs for arithmetic abacus skills, the research seeks to identify effective and efficient strategies, methods, materials, and techniques for conducting training that meets the specific needs of teachers at Madrasah Ibtidaiyah Bandar Lampung. The study adopts a qualitative approach with a case study method, selecting research subjects purposively. Data collection involves interviews, observations, and documentation, with the results analyzed descriptively qualitatively. The findings of this research emphasize the crucial importance of analyzing the training needs for arithmetic abacus skills in implementing training programs. Prior to conducting training for arithmetic abacus skills, it is essential to gain a comprehensive understanding of participants' initial skills, the methods typically used in their previous training experiences, participants' interests and responses to the upcoming training, as well as any challenges they face in arithmetic abacus skills. This ensures that the training outcomes align with the goals of the training program and meet the specific needs of Madrasah teachers, particularly at Madrasah Ibtidaiyah Bandar Lampung
The concept of teaching internal medicine subjects
Authors: Onuchina E. V. , Golubchikova M. G. 
Published: February 2024

Бурное развитие медицинской науки, из года в год возрастающий объем научно-технической информации, значительные успехи практического здравоохранения, все более широкое оснащение лечебно- профилактических учреждений сложной современной аппаратурой и оборудованием требуют дальнейшего совершенствования системы подготовки врачебных кадров.
SCDetect: A SeisComP Module for Real-Time Waveform Cross-Correlation-Based Earthquake Detection
Authors: Mesimeri Maria , Armbruster Daniel , Kästli Philip , Scarabello Luca , Diehl Tobias , Clinton John , Wiemer Stefan 
Published: February 2024

Abstract
Enhanced earthquake catalogs based on waveform cross correlation (template matching) have become routine when studying regional or sequence specific seismicity. Currently, there is no existing open-source cross-correlation software that is designed to be fully integrated in real-time operations of seismic networks. To fill this gap, we introduce SCDetect, a software that implements real-time earthquake detection based on waveform cross correlation in the time domain. SCDetect with the extension module scdetect-cc is an open-source SeisComP package written in C++. scdetect-cc can be used to process both archived waveform data (playback mode), and real-time data. In the real-time application, waveforms are fetched through one of the SeisComP RecordStream interfaces, and its output (picks, origin times, amplitudes, and magnitudes) are sent to the SeisComP messaging system. The new origins are associated either with existing events detected by other pick-based SeisComP modules, or create new events. Optionally, the hypocenter location can be refined by downstream application of existing SeisComP modules. scdetect-cc offers two magnitude estimation methods that are based on the amplitudes of the template earthquakes and the new detections. In the real-time application, scdetect-cc can be scaled to handle thousands of templates without overloading the application or becoming too latent, unable to keep up with the data flow. In the playback mode, we applied scdetect-cc to three recent earthquake sequences occurring in Switzerland and surrounding regions between 2019 and 2020. Two scenarios are tested to simulate its performance in real time. The first scenario cross correlates the signals of the nearest station, whereas the second requires four stations. In both cases, we successfully detected most of the cataloged events and added hundreds of new detections. Overall, scdetect-cc is a computationally efficient and highly customizable tool to detect earthquakes for regional networks that implement the SeisComP system for earthquake monitoring.
In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
Authors: Ebneali Faezeh , Shayestehpour Mohammad , Piroozmand Ahmad , Sedaghat Hossein , Yazdani Shaghayegh , Fateminasab Zahrasadat 
Published: February 2024

Background and Objectives: Human herpes virus type 1 (HSV-1) is a neurotropic pathogen that is infected more than 70% of the world population. The increasing of viral resistance to antiviral drugs and the emergence of side effects has motivated researchers to study the use of probiotics as new antiviral agents. The aim of the present study was to study for the first time the potential antiviral activity of Lactobacillus reuteri (L. reuteri) supernatant against HSV-1.
Materials and Methods: After measuring the cytotoxicity of L. reuteri supernatant by MTT assay, 1:16 dilution of it was added to HeLa cells before and after HSV-1 infection, after 1.5 hours incubation with HSV-1, and simultaneously with HSV[1]1 infection. After 48 hours of incubation at 37°C, the viral titer and expression levels of UL54, UL52 and UL27 genes were measured by tissue culture infectious dose 50 (TCID ) and Real-Time PCR methods, respectively.
Results: HSV-1 titer in the treatment conditions before infection, incubation with HSV-1, simultaneously with infection and after infection was reduced by 0.42, 3.42, 1.83, and 0.83 log 10 TCID /ml, respectively. When the bacterial supernatant was first incubated with the virus and then added to the cell, or when it was added simultaneously with the virus, the expression of the UL27, UL52, and UL54 genes decreased significantly (p0.05).
Conclusion: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1in- fection.
Educación y ciudadanización en Colombia
Authors: Espinel-Bernal Oscar 
Published: February 2024

La investigación realizada se soporta desde tres ejes de análisis: el sujeto-piadoso, el sujeto-patriota y el sujeto-laborioso. Tres ejes que se amalgaman en la formación de aquella forma de subjetividad que llamamos ciudadano y que se conjuga con la consolidación del proyecto de nación puesto en marcha en las últimas décadas del siglo XIX en Colombia. Además de buenos cristianos y buenos patriotas, los ciudadanos deben ser sujetos laboriosos, con visión de futuro y regidos por valores como el ahorro y el esfuerzo personal para contribuir a la prosperidad de la nación en medio de los crecientes cambios en los mercados y economías mundiales a la entrada del siglo XX. Allí serán capitales las técnicas disciplinarias y biopolíticas para la maximización de la productividad y la regulación de la opinión pública que empieza a aparecer como terreno fértil para el gobierno de las poblaciones y la cohesión del Estado. Dar una mirada a las formas de constitución de ciudadanos desde la distancia histórica que propone el libro permite no solo comprender los modos, funcionamientos y características de la formación ciudadana en Colombia, sino también problematizar y trazar nuevos horizontes de posibilidad frente a las prácticas de ciudadanización contemporáneas.
Replication and Injury Associated With SARS-CoV-2 in Cultured Hepatocytes
Authors: Pradhan Suman , Rouster Susan D. , Blackard Jason T. , Dean Gary E. , Sherman Kenneth E. 
Published: February 2024

Background: Liver dysfunction is one of the hallmarks of SARS-CoV-2 infection. The mechanism(s) of hepatic injury in SARS-CoV-2 infection remains controversial with some reporting viral replication and cellular injury and others suggesting lack of replication and injury due to non-cytopathogenic etiologies. To investigate this further, we evaluated SARS-CoV-2 replication in immortalized hepatic cell lines and primary hepatocytes, examined whether cell injury was associated with apoptotic pathways, and also determined the effect of the antiviral remdesivir on these processes.
Methods: Immortalized hepatocyte cell lines (HepG2 and Huh7.5), as well as primary human hepatocytes, were exposed to SARS-CoV-2 at a multiplicity of infection of 0.1 PFU/mL. Viral replication was evaluated by plaque assays, immunohistochemical staining for the viral spike protein, and caspase-3 expression evaluated with and without exposure to remdesivir.
Results: All hepatocyte cell lines and primary hepatocytes supported active replication of SARS-CoV-2. Significant cytopathic effect was observed by light microscopy, and caspase-3 staining supported activation of apoptotic pathways. Remdesivir abrogated infection in a dose-dependent fashion and was not independently associated with hepatocyte injury.
Conclusion: Hepatocytes appear to be highly permissive of SARS-CoV-2 replication which leads to rapid cell death associated with activation of apoptotic pathways. Viral replication and hepatocytes injury are abrogated with remdesivir. We conclude that active viral replication is most likely a key contributor to liver enzyme abnormalities observed in the setting of acute SARS-CoV-2 infection.
Dynamic Foot Pressure During Walking: A Potential Indicator of Bone Mineral Density
Authors: Choi Yoon Hyo , Choi Ji Hye , Koo Seungbum , Han Hee Soo , Lee Dong Yeon , Lee Kyoung Min 
Published: February 2024

Background:
Physical skeletal loading can affect the bone mineral density (BMD). This study investigated the association between BMD and dynamic foot pressure during gait.

Methods:
A total of 104 patients (mean age, 62.6 ± 12.4 years; 23 male and 81 female) who underwent dual x-ray absorptiometry and pedobarography were included. BMD values of the lumbar spine, femoral neck, and total femur were assessed. The mean and maximum pressures were measured at the hallux, lesser toes, 1st metatarsal head, 2nd and 3rd metatarsal heads, 4th and 5th metatarsal heads, midfoot, medial heel, and lateral heel. Multivariable regression analysis was performed to identify factors significantly associated with BMD.

Results:
The lumbar spine BMD was significantly associated with the mean pressure at the 4th and 5th metatarsal heads (p = 0.041, adjusted R2 of model = 0.081). The femoral neck BMD was significantly associated with the maximum pressure at the 2nd and 3rd metatarsal heads (p = 0.002, adjusted R2 = 0.213). The total femoral BMD also showed a significant association with the maximum pressure at the 2nd and 3rd metatarsal heads (p = 0.003, adjusted R2 = 0.360).

Conclusions:
Foot plantar pressure during gait was significantly associated with BMD, and could potentially be used to predict the presence of osteoporosis.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Early Proterozoic Polymigmatites in a Zone of Granulite Metamorphism: P–T–X Conditions, Age, and Duration of Migmatization (Northern Ladoga Area, Russia)
Authors: Baltybaev Sh.K. , Yurchenko A.V. , Rizvanova N.G. , Vivdich E.S. , Galankina O.L. , Borisova E.B. 
Published: February 2024

Abstract
—Polymigmatites in the Early Proterozoic metamorphic complex of the Northern Ladoga area trace the evolution of thermodynamic conditions during anatexis. The P–T conditions inferred for anatectic leucosome correspond to the onset of partial melting under granulite facies conditions of 5.5–6.2 kbar and 720–810 °C. After the peak of metamorphism, pressure and temperature show a coupled decrease to 4 kbar and ~550 °C, respectively. The latest granitic veins were intruded into metamorphic rocks during an event of brittle deformation. The P–T trend correlates with changes in migmatitic mineral assemblages and in chemistry of minerals. Newly formed leucocratic material changed from plagiogranitic to granitic composition when melting involved plagiogneiss but melt derived from Al-rich metapelite remained granitic. The analyzed leucosomes and granitic veins originated by multistage melting, under P–T conditions changing from granulite to amphibolite facies, between 1875 and 1865 Ma. Judging by their ages, the leucosome and granitic vein bodies from the Lakhdenpokhia and Priozersky zones of the area differed in the total duration of crystallization. Therefore, a single thermal event involving different lithologies can produce intrusions of different ages.
Computational Fluid Dynamics Modeling and Analysis of Axial and Radial Temperature of Wellbore during Injection and Production Process
Authors: Zheng Jie , Hu Zhihao , Wang Weixiao , Dou Yihua , Li Jiahui , Yang Xu , Zhang Yarong , Cao Yinping 
Published: February 2024

Summary
To solve problems such as additional tubing/casing load, casing deformation, and packer failure caused by changes in annular temperature during oil and gas reservoir fracturing and production, based on the well structure of oil and gas reservoirs and transition transient heat transfer mechanism, a four-field coupling simulation model of the temperature field in the main fluid domain of the tubing, the temperature field in the solid domain of the tubing, the temperature field in the annular fluid domain, and the temperature field in the solid domain of the casing is proposed. Considering the coupling of fluid temperature, pressure, and physical parameters, boundary conditions are established based on reservoir characteristics, wellbore heat transfer characteristics, and fracturing and production conditions, and are compiled into Fluent software for simulation through the user-defined function (UDF) method. The effects of the temperature and flow rate of injected fracturing fluid and produced oil and gas on the distribution of the wellbore temperature field and temperature gradient are studied. The research results show that by applying D14-1 and D5-5 gas wells to the model, the simulated temperature is in good agreement with the measured wellbore temperature, and the maximum errors of the simulated values of the two different wells are 6.4% and 4.3%, respectively. As the injection and production operation time increase, the heat transfer between the wellbore and the formation gradually stabilizes. At this time, the injection and production flow rate have little impact on the wellbore temperature field, while the injection and production temperature have a greater impact on the wellbore temperature field. The injection and production temperature will cause changes in annular temperature and temperature gradient, leading to an increase or decrease in pressure within a limited annular volume, resulting in local stress on the tubing and casing. The research results can provide a theoretical basis for the analysis of the temperature field and pressure field of the wellbore during fracturing and oil and gas production, ensuring the safety and stability of fracturing and production.