bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐Effectiveness of Hominis Placenta Therapy for Chronic Temporomandibular Disorder: An Economic Evaluation Alongside a Pragmatic Randomised Controlled Trial
Authors: Kim Doori , Kim Eun‐San , Kim Koh‐Woon , Cho Jae‐Heung , Lee Yoon Jae , Ha In‐Hyuk 
Published: February 2025

ABSTRACTBackgroundHominis placenta (HP) exhibits anti‐inflammatory, antiviral and nerve growth‐promoting properties; however, there are limited studies about HP therapy in the treatment of temporomandibular disorder (TMD).ObjectiveTo evaluate the cost‐effectiveness of HP therapy with that of physical therapy (PT) in patients with TMD.MethodsThis cost‐effectiveness analysis was conducted alongside a 26‐week multicentre pragmatic randomised controlled trial (RCT). Eighty‐two patients with chronic TMD were randomly assigned to the HP and PT groups at a ratio of 1:1. Patients with a visual analogue scale (VAS) score of ≥ 40 mm for temporomandibular joint pain and persistent pain for ≥ 3 months were included. The primary economic endpoint was the incremental cost‐effectiveness ratio, which analysed the cost per quality‐adjusted life years (QALYs) gained in the HP group. QALYs were calculated using EuroQol‐5D (EQ‐5D) and Short‐Form 6D (SF‐6D). The primary and secondary analyses were conducted from societal and healthcare perspectives.ResultsHP therapy was the dominant treatment option from a societal perspective owing to its higher QALY and lower cost compared with those of PT. Differences in QALYs calculated using EQ‐5D and SF‐6D between the two groups were 0.015 and 0.034, respectively, while those in cost from societal perspectives and healthcare perspectives were −3764 and 113 USD, respectively. Analysis from a healthcare perspective indicated that the incremental cost‐effectiveness ratio calculated using the EQ‐5D and SF‐6D was 7786 and 3338 USD, respectively.ConclusionHP therapy is a more cost‐effective therapeutic option than PT for patients with chronic TMD.Trial RegistrationClinicalTrials.gov identifier: NCT04087005; Clinical Research Information Service KCT0004437
Distinct but Redundant Roles of ER Cargo Receptors p24 and Erv29 in Facilitating Proper Secretion of Cellulases in Trichoderma reesei
Authors: Wang Zhixing , Liu Lin , Pu Yi , Fang Yu , Lv Wenhao , Liu Weifeng 
Published: February 2025

ABSTRACTTrichoderma reesei represents an important industrial workhorse for (hemi)cellulase production. However, relatively little is known about the details of its secretory pathway ensuring the extremely high‐level enzyme secretion and how they might be leveraged for engineering improved protein production. Here, the functions of T. reesei ER cargo receptors p24 and Erv29 in trafficking cellulase were characterised. Whereas individual deletion of p24 or erv29 resulted in only a marginal effect on extracellular cellulase secretion, distinct intracellular trafficking pathways exist for individual hydrolytic enzyme in T. reesei. Notably, the simultaneous absence of p24 and Erv29 abolished the secreted production of cellulases but not xylanases. The secretion defect was accompanied by an apparent intracellular accumulation of cellulases. Mutations of residues on the cytosolic side of p24 and Erv29 supposed to mediate COPII coat recognition also compromised cellulase secretion although the overall ER exit sites (ERES) formation did not seem to be affected. We further revealed that a VPL motif following the signal peptide of CBH2 necessitates its efficient secretion mediated by Erv29. These results indicate that two specific ER cargo receptors complement each other to mediate the proper intracellular trafficking of cellulases and thus ensuring their extracellular secretion.
Non‐Invasive, Bioluminescence‐Based Visualisation and Quantification of Bacterial Infections in Arabidopsis Over Time
Authors: Taks Nanne W. , Batstra Mathijs D. , Kortekaas Ronald F. , Stevens Floris D. , Pfeilmeier Sebastian , van den Burg Harrold A. 
Published: February 2025

ABSTRACTPlant‐pathogenic bacteria colonise their hosts using various strategies, exploiting both natural openings and wounds in leaves and roots. The vascular pathogen Xanthomonas campestris pv. campestris (Xcc) enters its host through hydathodes, organs at the leaf margin involved in guttation. Subsequently, Xcc breaches the hydathode–xylem barrier and progresses into the xylem vessels causing systemic disease. To elucidate the mechanisms that underpin the different stages of an Xcc infection, a need exists to image bacterial progression in planta in a non‐invasive manner. Here, we describe a phenotyping setup and Python image analysis pipeline for capturing 16 independent Xcc infections in Arabidopsis thaliana plants in parallel over time. The setup combines an RGB camera for imaging disease symptoms and an ultrasensitive CCD camera for monitoring bacterial progression inside leaves using bioluminescence. The method reliably quantified bacterial growth in planta for two bacterial species, that is, vascular Xcc and the mesophyll pathogen Pseudomonas syringae pv. tomato (Pst). The camera resolution allowed Xcc imaging already in the hydathodes, yielding reproducible data for the first stages prior to the systemic infection. Data obtained through the image analysis pipeline was robust and validated findings from other bioluminescence imaging methods, while requiring fewer samples. Moreover, bioluminescence was reliably detected within 5 min, offering a significant time advantage over our previously reported method with light‐sensitive films. Thus, this method is suitable to quantify the resistance level of a large number of Arabidopsis thaliana accessions and mutant lines to different bacterial strains in a non‐invasive manner for phenotypic screenings.
The Loss of the Nurse as an Individual: Nursing, Well‐Being and Existentialism
Authors: Livingston Marci Kay , Manning Stacy 
Published: February 2025

ABSTRACTResearch into how existentially aware nurses and nursing interventions have highlighted the benefits to patients and patient outcomes. Less is known about how existentially based training affects nurses themselves. This project sought to understand if and how a training programme developed to improve nurses' knowledge of existential theory would affect their well‐being. Overall, despite challenges to recruitment, follow‐up and data collection, three key themes were developed from the data: (1) Things Are Difficult, (2) We Need More… and (3) Well‐Being Is Personal. Existentialist philosophy can be an effective way of providing nurses with the tools to develop and express their own definition of well‐being. It can also be useful to healthcare systems and administrators seeking to find ways of reducing burnout and turnover among nursing staff.
Attenuated Doors‐Locked P300 Amplitude and Elevated Depressive Symptoms: Effects of Age and Sex in Two Independent Samples of Youth
Authors: Santopetro Nicholas J. , Amir Nader , Nelson Brady D. , Klein Daniel N. , Hajcak Greg 
Published: February 2025

ABSTRACTDeficits in cognitive and reward‐related functions, measured via reductions in the P300 and reward positivity (RewP) event‐related potential (ERP) components, are commonly observed in adults suffering with depression. Considering higher risk for depression emerges among females in adolescence, examination of the neurological underpinnings of depression during this critical developmental period can help further elucidate our overall understanding of the etiology of depressive disorders. Therefore, the present study sought to first examine associations between doors‐locked P300 amplitude, RewP amplitude, current depression symptoms, and age in an all‐female youth sample (sample 1: n = 296; age, 8 to 14). Next, we examined these same associations, as well as sex, in a second independent sample consisting of male and female youths (sample 2: n = 605; age, 11 to 14). Blunted doors‐locked P300 was associated with higher depressive symptoms in both samples. Moreover, the association between P300 and depression was stronger among older youths in both samples. Sex further moderated this relationship in sample 2 such that smaller P300 related to greater depression only in females. There were no consistent associations between RewP amplitude and depressive symptoms in either youth sample. These findings suggest that the doors‐locked P300 component is a reliable neural correlate of depression in youth that might specifically relate to pathways linked to increased risk for depression among adolescent females.
Key attributes of health and environmental risk decision‐making: A scoping review
Authors: Bhuller Yadvinder , Bancroft Xaand , Deonandan Raywat , Grudniewicz Agnes , Wiles Anne , Krewski Daniel 
Published: February 2025

AbstractGovernment agencies, international institutions, and independent experts have published approaches for the assessment and management of health and environmental risks. This includes evidence‐based strategies and publications supporting risk decision‐making frameworks reflecting contemporary practices, the overarching context, and governance structures for addressing known and emerging risk issues. This scoping review surveys the literature, over the last five decades, to identify key attributes of health and environmental risk decision‐making and how these inherent characteristics are related to the overarching regulatory decision‐making context. The findings provide insights on how these publications accounted for the circumstances and triggers at that time. This includes incorporating factors reflecting advances in science and technology, a better understanding of underlying values (e.g., societal), and an expansion in the scope and complexity required for conducting different evaluations relevant to health and environmental risks. Consequently, the evolution from linear to more expanded and holistic decision‐making frameworks incorporates foundational elements, such as the well‐established steps for assessing risks, while adding aspects reflecting transformative changes and paradigm shifts (e.g., the use of non‐animal testing strategies for evaluating human safety). Our analysis also resulted in the generation of a consolidated listing of ten attributes: trigger/issue, regulatory context, regulatory factors, core values, risk decision‐making principles, cross‐cutting attributes, design (scope and steps), structure, decision‐making pathway, and evidence‐knowledge requirements for risk decision‐making. A better understanding of this evolution in risk decision‐making and the listing of key attributes will be used in future work aimed at developing considerations for next generation decision‐making approaches for health and environmental risks.
Wind‐driven hydrodynamic and depositional patterns in shallow lakes: An exploratory modelling approach based on an archetypal case of Lake Hulun
Authors: Xue Xinyu , Storms Joep , Zăinescu Florin , Schuster Mathieu , Wang Li , May Jan‐Hendrik , Ng Zhi Lin , van der Vegt Helena , Nutz Alexis , Bozetti Guilherme , Su Ming , Jiang Zaixing 
Published: February 2025

ABSTRACTLake Hulun, the fifth‐largest lake in China, is a shallow lake (water depth <10 m) with typical wave‐dominated landforms developed around the shoreline, with a semi‐enclosed bay located in its southern corner. This novel study aims to understand wind‐driven hydrodynamics and its related depositional patterns in the data‐sparse Lake Hulun. To achieve this, a series of numerical simulations were conducted with a hydrodynamic and sediment transport model. The simulated hydrodynamic patterns are greatly influenced by wind direction shifts but are subject to little impact from wind speed changes which act mainly to accelerate flow. By varying the location and depth of the deepest part of the lake, this study reveals that the location of the depth centre has little impact on the overall hydrodynamic pattern of wind‐driven waterbodies. When the wind direction is perpendicular to the long‐axis shore, currents around the short‐axis shore flow in a direction that follows the wind direction. This study considers the wind‐induced longshore currents that are oblique to the long‐axis shore as the main driving force in transporting sediments along the shore and erosion of the shoreline. The formation of semi‐closed bays in both Lake Hulun, together with its nearby sister lake – Lake Buir – are attributed to the north‐west prevailing wind direction. Further exploratory simulations confirmed that prevailing winds tend to induce parallel distributed submerged sediment accumulations in the nearshore zone, challenging the notion of sediment accumulation solely in deep water zones. This study provides valuable insights into the hydro‐sedimentary dynamics in wind‐driven waterbodies, offering a process‐based perspective and contributing to current understanding of the palaeogeography of ancient lake systems.
How does Social Trust Shape the Politicization of America’s Climate Change Perception?—A Study of Two National Surveys in 2022 and 2023
Authors: Hao Feng , Doyle Joshua 
Published: February 2025

ABSTRACTClimate change has exerted tremendous disruptive impacts on the planet and human society. The United States is a major contributor to this crisis and has witnessed extreme weather events more frequently in recent years. To address this issue, it is critical to understand how Americans understand climate change. Our study uses data from two national surveys administered in 2022 and 2023 to investigate this topic. Descriptive statistics reveal that most Americans are concerned about the risk, recognize the ramifications of extreme weather events, agree that transforming to renewables is a practical solution, and support the Inflation Reduction Act to tackle the climate crisis. Structural equation modeling results show social trust and political ideology shape climate change perception. Social trust also mediates the impact of political ideology, with respondents who lean liberal becoming even more likely to perceive the threat of climate change and concur with climate policies if they have stronger social trust. The findings contribute to the literature and carry significant policy implications. Studying social trust’s direct and mediating effects by examining an American sample complements most current scholarship using cross‐national data and only probing the direct linkage. Meanwhile, it is critical to leverage social trust’s influence to bridge the political gap and promote public response to climate change.
Navigating Populism in America: Unveiling the Socioeconomic and Ideological Roots of Populist Attitudes
Authors: Jung Yujin J. 
Published: February 2025

AbstractObjectivesThis study investigates the socioeconomic and ideological factors that are associated with populist attitudes in the United States. Specifically, it examines the influence of demographic factors such as age and religious affiliation, alongside economic perceptions, while also exploring the ideological alignment of populist attitudes with conservative and progressive issue stances.MethodsThe analysis utilizes original survey data collected from a nationally representative sample of U.S. respondents. Employing a combination of ordinary least squares regression and factor analysis, the study evaluates the interrelationships between key socioeconomic indicators, ideological orientations, and populist sentiments.ResultsThe analysis reveals that populist attitudes are strongly associated with conservative issues such as opposition to immigration, support for gun rights, and abortion restrictions. Among socioeconomic predictors, Christian affiliation emerges as one of the significant socioeconomic predictors of populist attitudes. In contrast, populist attitudes show no substantial association with progressive issues like healthcare expansion, environmental policies, or United States involvement in Ukraine.ConclusionThe findings suggest that populism at the mass level in the United States is predominantly aligned with right‐wing issues, rather than left‐wing ones. This alignment indicates that populist attitudes in the United States reinforce ideological divides, particularly around conservative policy positions.
Synergistic lubrication effect of texture and copper on cutting performance for broaching tool
Authors: Feng Kai , Song Ziqi , Ni Jing , Wang Xiaozhen , Du Mingyang 
Published: February 2025

Abstract
The broaching process is a heavy-duty and highly efficient metal cutting technique. The heavy load encounters significant thermal and mechanical stresses on the tool during broaching, resulting in considerable friction within the tool-chip contact area. The friction adversely affects both workpiece quality and tool life. To address this issue, laser technology is utilized in this study to create three distinct textures on the rake face of the broach. Subsequently, an innovative rotary covering device is developed to cover a solid lubricant (copper) onto both surfaces and grooves of cutting tool. Broaching test is conducted to evaluate the impact of different textures and copper on chip morphology, including chip deformation and burr width. The findings demonstrate that employing a stripe-textured broach reduces the chip deformation coefficient by 16.1% compared to its non-textured counterpart. Furthermore, covering copper through rotational friction leads to an additional reduction of 7.7% in the chip deformation coefficient. Copper not only repairs surface defects but also forms a lubricating film during cutting operations, thereby serving as an effective solid lubricant. The synergistic interaction between texture and copper enhances heat dissipation during cutting processes, consequently reducing temperatures within the tool-chip contact area. The temperature reduction alleviates plastic deformation in localized regions of the workpiece, resulting in narrower burrs. Therefore, the use of rotary friction for covering copper onto the rake face of a broaching tool represents a straightforward yet cost-effective strategy for optimizing frictional conditions and enhancing the cutting performance.
A novel fault identification method for rolling bearing
Authors: Li Yongpeng , Yu Mingyue , Meng Guanglei , Wang Yunbo 
Published: February 2025

Abstract
One-dimensional local binary pattern (1D-LBP) identifies the running state of bearings by describing local textural features of vibration signals. However, 1D-LBP algorithm is rather sensitive to noise and intrinsic periodic features of rotating machinery which is not included in consideration. This makes it difficult for 1D-LBP algorithm to comprehensively dig fault information of bearings. To solve this problem, a new method has been brought forward by combining the intrinsic periodicity of rotating machinery and extraction of textural features. Before extraction of local features of signals, vibration signals are subjected to first-order difference operation to highlight local impact features of bearing failure. Meanwhile, to reduce the noise and further strengthen periodic features, differential signals are segmented by a complete period, and the signals after segmentation are subjected to cross-correlation successively to acquire the corresponding cross-correlation functions. Secondly, 1D-LBP is employed on cross-correlation functions (not raw signals) to extract local features and local textural signals (LTS) are obtained. Thirdly, feature parameters and vectors have been built according to LTS and the running state of bearings has been described from the perspective of textural feature. At last, according to established feature vector and classification algorithm, running state of bearing was determined. A comparative analysis is given to proposed method and other methods through public data sets and data from an experimental equipment of bearing. The results of comparative analysis indicate that with the 2 kinds of data sets, the identification rate of proposed method for unknown samples is over 97% and it can judge the running state and the type of faults more precisely.
Research on the Static and Dynamic Characteristics of Porous Air Bearings Considering Annular Groove Air Supply
Authors: Tian Boyu , Zhang Xiaofeng , Xu Jin , Zhu Fuan 
Published: February 2025

Abstract
The article examines the dynamic characteristics of porous air bearings in the critical pneumatic hammer state (the transition state from the steady state to the pneumatic hammer state). The dynamic characteristics mainly include the critical load (film load capacity) and the critical frequency (vibration frequency) of the bearings. This study presents two fluid domain models: the first model depicts flow channels with annular grooves for air supply (annular grooved model), while the second model does not include annular grooves (nongrooved model). The effects of bearing permeability and air supply pressure are analyzed. Numerical simulation results show that the critical loads and the critical frequencies in the annular grooved model are quite different from those in the nongrooved model. When the permeability is 1.33 × 10−14 m2 and the supply pressures are 400 kPa, 450 kPa, and 500 kPa, the critical loads in the annular groove model are 54.5 N, 48.9 N, and 45.9 N, while the critical loads in the nongrooved model are 42 N, 52.5 N, and 68 N. Reducing the permeability of the air bearing significantly increases the critical load and the critical frequency. Finally, an experimental facility is set up to investigate the critical load and the critical frequency of the air bearings. The critical loads in the experiment are 59.1 N, 52.5 N, and 49.3 N. The fluid domain model's and solution method's accuracy has been confirmed. The simulation results of the annular grooved model are closer to the experimental results.
Power Loss Minimization Through Maximal Power Endurance or Repeated Power Training Programs
Authors: Gonzalo-Skok Oliver , Tous-Fajardo Julio 
Published: February 2025

Purpose: The present study analyzed the effects of a maximal-power-endurance (MPE) versus a repeated-power-ability (RPA) training program on different strength, power, and repeated-power measurements in a short- and long-term training period and the relationships between changes in all variables. Methods: Twenty-two young highly trained male basketball players were randomly allocated to 1 of the 2 groups (MPE, n = 11; RPA, n = 11) and evaluated by 1-repetition maximum and incremental load, RPA, and MPE tests in the bench-press exercise before and after a period of 4 and 8 weeks. The MPE group performed 2 to 4 sets of a postdetermined number of repetitions (ie, set stopped when maximum power output decreased >10%) using the load that maximized power output. The RPA group carried out 1 to 3 blocks of 5 sets of 5 repetitions with a load that maximized power output. Results: Both groups significantly (P < .001; effect size = 0.58; 1.56) improved 1-repetition maximum, maximum power output, and 20%, 40%, 60%, and 80% of 1-repetition maximum from pretest to posttest in the incremental load test. Significant improvements (P < .001) were found for the RPA and MPE groups in the best, mean, and last set in the RPA test at all times. Furthermore, a significant (P < .001) time × group interaction was found in the MPE test, showing significant improvements in both groups at posttest. In addition, at posttest, intraset power fluctuation in the mean was significantly (P < .05; effect size = 0.45) better in MPE group compared with RPA group. Conclusion: In conclusion, both training programs represent appropriate methods to improve neuromuscular measurements, although MPE training seems to be a more volume-efficient strategy (∼50% fewer repetitions) to enhance several fatigue-resistance indexes (intraset power fluctuation in the mean).