bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les perturbateurs des hormones thyroïdiennes : comment estimer leurs impacts sur la santé humaine et l’environnement ?
Authors: Rannaud-Bartaire Patricia , Fini Jean-Baptiste 
Published: November 2023

Les perturbateurs endocriniens (PE) d’origine chimique font l’objet de nombreuses études, certaines ayant permis des mesures visant à limiter leur utilisation et leurs impacts sur l’environnement et la santé humaine. Des dizaines d’hormones ont été décrites et sont communes à l’ensemble des vertébrés (certains messagers chimiquement proches ont été également répertoriés chez les invertébrés) avec des rôles variables et pas toujours connus. Les effets des PE concernent donc potentiellement toutes les espèces animales via tous les axes endocriniens ; ils s’ajoutent aux autres paramètres de l’exposome qui induisent une pression d’adaptation forte, multiple, et difficile à appréhender. Les effets des PE sur les voies de la reproduction et les voies thyroïdiennes sont parmi les plus étudiés depuis ces trente dernières années et ce, sur un grand nombre d’espèces. L’étude des effets des PE sur les voies thyroïdiennes ainsi que sur le développement cérébral va de pair avec l’augmentation des connaissances sur 1) les différents rôles des hormones thyroïdiennes au niveau cellulaire ou tissulaire (notamment le tissu cérébral en développement) chez de nombreuses espèces, 2) les autres voies hormonales et 3) les interactions épigénétiques. De façon générale, si l’on veut appréhender comment agissent les PE sur les organismes vivants, il est nécessaire d’analyser dans une approche intégrée et multi-modèles (approche dite translationnelle) les résultats issus de domaines scientifiques complémentaires. Dans cette brève revue, nous dressons un état des lieux de découvertes récentes et discutons les perspectives d’action dans les champs de la médecine et de la recherche. Nous mettons en avant la nécessité d’une approche intégrée et multidisciplinaire pour étudier les impacts des PE et prendre des mesures appropriées.
Nasal Patency Measurement: State of the Art of Acoustic Rhinometry
Authors: Ottaviano Giancarlo 
Published: November 2023

AbstractNasal obstruction is one of the main symptoms of different nasal pathologies. Many physiological and pathological conditions can produce nasal airflow impairment causing nasal obstruction and affecting patients' quality of life. There are different methods for the measurement of nasal obstruction, but in clinical practice the most common used are acoustic rhinometry, rhinomanometry, and peak nasal inspiratory flow. This review describes the fundamentals of acoustic rhinometry, its normal values, the different physiological and pathological conditions that can modify nasal patency, and the utility of this instrument for the measurement of nasal obstruction in clinical practice. Acoustic rhinometry is a simple test, so it is suitable for measurements in the pediatric population, i.e., for evaluating adenoid hypertrophy. Acoustic rhinometry normal values are available, unilaterally and bilaterally for pediatric and adult populations. Acoustic rhinometry has been demonstrated to be reproducible and even superior to rhinomanometry when measuring nasal modifications during challenges. It is possible to use acoustic rhinometry before and after nasal surgery. Measuring nasal cavities volume and cross-sectional area, acoustic rhinometry is particularly indicated in rhinosurgery, especially for the evaluation of spreader grafts. Brief considerations about the correlation between nasal symptoms, in particular the subjective sensation of nasal obstruction, and the acoustic rhinometry results as well as the correlation of acoustic rhinometry with other methods for the measurement of nasal obstruction are also reported. Objective and subjective evaluation of nasal obstruction gives different information that together optimizes the diagnosis and the treatment of rhinologic patients. Acoustic rhinometry alone or in combination of other instruments for the measurement of nasal obstruction or patency should be used regularly in every outpatient clinic that treats patients with nasal obstruction as there is an increasing need of evidence-based therapies.
Effectiveness of an Educational Intervention with Guidelines from the Total Acceleration of Postoperative Recovery Project (ACERTO) in Gynecology
Authors: Marra Juliana Marques , Samper Isabela Corrêa , Abreu Laura Aparecida Xavier de , Anelvoi Rafaela Pereira , Uyeda Maria Gabriela Baumgarten Kuster , Sartori Marair Gracio Ferreira , Marquini Gisele Vissoci 
Published: November 2023

Abstract
Objective To evaluate the effectiveness of an educational intervention among gynecologists about recommendations of the Total Acceleration of Postoperative Recovery (ACERTO, in the Portuguese acronym) project derived from the solid foundations of Enhanced Recovery After Surgery (ERAS) guidelines to optimize hospital care for surgical-gynecological patients.
Methods Educational intervention through monthly 1-hour long meetings (3 months), with the application of an objective questionnaire about specific knowledge of the ACERTO project between before and after educational intervention phases, for gynecologists, after approval by the ethics committee and signature of informed consent by participants, in a federal university hospital.
Results Among the 25 gynecologists who agreed to participate, the educational intervention could be effective with a statistically significant difference between the phases before and after the intervention for the main recommendations of the ACERTO project, such as abbreviation of preoperative fasting (p = 0.006), venous thromboembolism prophylaxis (p = 0.024), knowledge and replication of ACERTO (p = 0.034), and multimodal analgesia (p = 0.021).
Conclusion An educational intervention, through clinical meetings with exposition and discussion of the recommendations of the ACERTO project based on the ERAS protocol can be effective for the knowledge and possibility of practical application of the main measures, such as abbreviation of preoperative fasting, multimodal analgesia, and prophylaxis of thrombosis among gynecologists.
Bleeding Scoring Systems in Neonates: A Systematic Review
Authors: Sokou Rozeta , Parastatidou Stavroula , Konstantinidi Aikaterini , Tsantes Andreas G. , Iacovidou Nicoletta , Piovani Daniele , Bonovas Stefanos , Tsantes Argirios E. 
Published: November 2023

AbstractWe conducted a systematic review aiming to summarize the data on the current hemorrhage prediction models and evaluate their potential for generalized application in the neonatal population. The electronic databases PubMed and Scopus were searched, up to September 20, 2023, for studies that focused on development and/or validation of a prediction model for bleeding risk in neonates, and described the process of model building. Nineteen studies fulfilled the inclusion criteria for the present review. Eighteen bleeding risk prediction models in the neonatal population were identified, four of which were internally validated, one temporally and one externally validated. The existing prediction models for neonatal hemorrhage are mostly based on clinical variables and do not take into account the clinical course and hemostatic profile of the neonates. Most studies aimed at predicting the risk of intraventricular hemorrhage (IVH) reflecting the fact that IVH is the most frequent and serious bleeding complication in preterm neonates. A justification for the study sample size for developing the prediction model was given only by one study. Prediction and stratification of risk of hemorrhage in neonates is yet to be optimized. To this end, qualitative standards for model development need to be further improved. The assessment of the risk of bleeding incorporating platelet count, coagulation parameters, and a set of relevant clinical variables is crucial. Large, rigorous, collaborative cohort studies are warranted to develop a robust prediction model to inform the need for transfusion, which is a fundamental step towards personalized transfusion therapy in neonates.
Plasma window performance and scaling for an accelerator-based neutron source
Authors: Blatz J. M. , Barrows P. , Kile T. , Hoerr D. , Gribb T. , Hershcovitch A. , Radel R. 
Published: November 2023

A “plasma window” was developed for use with a SHINE accelerator-based neutron source. In this work, the design of the plasma window is presented along with results demonstrating successful operation in deuterium over a range of aperture diameters (5–12 mm), gas flow rates (3.5 to 12.5 slm), and input powers (10–55 kW). An empirically determined relationship between the aperture diameter, deuterium gas flow rate, input power, and plasma window pressure differential is also presented.
Magnetic optical rotation from real-time simulations in finite magnetic fields
Authors: Ofstad Benedicte Sverdrup , Wibowo-Teale Meilani , Kristiansen Håkon Emil , Aurbakken Einar , Kitsaras Marios Petros , Schøyen Øyvind Sigmundson , Hauge Eirill , Irons Tom J. P. , Kvaal Simen , Stopkowicz Stella , Wibowo-Teale Andrew M. , Pedersen Thomas Bondo 
Published: November 2023

We present a numerical approach to magnetic optical rotation based on real-time time-dependent electronic-structure theory. Not relying on perturbation expansions in the magnetic field strength, the formulation allows us to test the range of validity of the linear relation between the rotation angle per unit path length and the magnetic field strength that was established empirically by Verdet 160 years ago. Results obtained from time-dependent coupled-cluster and time-dependent current density-functional theory are presented for the closed-shell molecules H2, HF, and CO in magnetic fields up to 55 kT at standard temperature and pressure conditions. We find that Verdet’s linearity remains valid up to roughly 10–20 kT, above which significant deviations from linearity are observed. Among the three current density-functional approximations tested in this work, the current-dependent Tao–Perdew–Staroverov–Scuseria hybrid functional performs the best in comparison with time-dependent coupled-cluster singles and doubles results for the magnetic optical rotation.
Addressing Antimicrobial Resistance (AMR) on Dairy Farms: A One Health Case Study from Punjab, India
Authors: Vijay Deepthi , Dhaka Pankaj , Bedi Jasbir Singh 
Published: November 2023

Abstract
This case study explores the antimicrobial usage (AMU) practices on Punjab’s dairy farms, aiming to address the challenge of antimicrobial resistance (AMR) through collaborative efforts. It uncovers diverse AMU practices contributing to misuse, particularly on farm management-related diseases, such as mastitis, reproductive disorders, diarrhoeal diseases, and blood parasite infections. Some animal farms displayed high AMU levels of ‘critical importance’ category antibiotics, as per the World Health Organization. Additionally, some farmers exhibited inadequate knowledge and understanding of the importance of completing adequate antimicrobial therapy courses. The key risk factors for incorrect AMU include lack of awareness among the informal animal health service providers (without formal education/qualification), over-the-counter access of antibiotics, self-treatment practices by the farmers, and limited understanding of AMR’s public health implications. The study undertook a series of initiatives to combat AMR, including subject awareness workshops, biosecurity awareness activities comprising proper disposal of farm waste, and workshops for veterinarians, para-veterinarians, and farmers, sensitizing about AMR’s adverse consequences. Recommendations include enhancing access to qualified veterinarians, discouraging reliance on unauthorized practitioners, enhancing diagnostic capabilities, and providing technical support for disease prevention. Establishing AMU and AMR surveillance systems is essential for informed decision-making. Collaborative efforts are vital to raise awareness, promote responsible AMU, and ensure animal and public health security. These joint actions among dairy chain stakeholders are imperative to combat AMR and foster sustainable dairy production while protecting animal and human health.

Information
© The Authors 2023
Jointly determining the point sources and obstacle from Cauchy data
Authors: Zhang Deyue , Chang Yan , Guo Yukun 
Published: November 2023

Abstract
A numerical method is developed for recovering both the source locations and the obstacle from the scattered Cauchy data of the time-harmonic acoustic field. First of all, the incident and scattered components are decomposed from the coupled Cauchy data by the representation of the single-layer potentials and the solution to the resulting linear integral system. As a consequence of this decomposition, the original problem of joint inversion is reformulated into two decoupled subproblems: an inverse source problem and an inverse obstacle scattering problem. Then, two sampling-type schemes are proposed to recover the shape of the obstacle and the source locations, respectively. The sampling methods rely on the specific indicator functions defined on target-oriented probing domains of circular shape. The error estimates of the decoupling procedure are established and the asymptotic behaviors of the indicator functions are analyzed. Extensive numerical experiments are also conducted to verify the performance of the sampling schemes.
Effect of different oxygen precursors on alumina deposited using a spatial atomic layer deposition system for thin-film encapsulation of perovskite solar cells
Authors: Asgarimoghaddam Hatameh , Chen Qiaoyun , Ye Fan , Shahin Ahmed , Song Bo , Musselman Kevin P 
Published: November 2023

Abstract
An atmospheric-pressure spatial atomic layer deposition system operated in atmospheric-pressure spatial chemical vapor deposition conditions is employed to deposit alumina (AlO
x
) thin films using trimethylaluminum and different oxidants, including water (H2O), hydrogen peroxide (H2O2), and ozone (O3). The impact of the oxygen precursor on the structural properties of the films and their moisture-barrier performance is investigated. The O3-AlO
x
films, followed by H2O2-AlO
x
, exhibit higher refractive indexes, lower concentrations of OH− groups, and lower water-vapor-transmission rates compared to the films deposited using water (H2O-AlO
x
). The AlO
x
films are then rapidly deposited as thin-film-encapsulation layers on perovskite solar cells at 130 °C without damaging the temperature-sensitive perovskite and organic materials. The stability of the p–i–n formamidinium methylammonium lead iodide solar cells under standard ISOS-D-3 testing conditions (65 °C and 85% relative humidity) is significantly enhanced by the encapsulation layers. Specifically, the O3-AlO
x
and H2O2-AlO
x
layers result in a six-fold increase in the time required for the cells to degrade to 80% of their original efficiency compared to un-encapsulated cells.
Physiological sensor data cleaning with autoencoders
Authors: Kriara Lito , Zanon Mattia , Lipsmeier Florian , Lindemann Michael 
Published: November 2023

Abstract

Objective. Physiological sensor data (e.g. photoplethysmograph) is important for remotely monitoring patients’ vital signals, but is often affected by measurement noise. Existing feature-based models for signal cleaning can be limited as they might not capture the full signal characteristics. Approach. In this work we present a deep learning framework for sensor signal cleaning based on dilated convolutions which capture the coarse- and fine-grained structure in order to classify whether a signal is noisy or clean. However, since obtaining annotated physiological data is costly and time-consuming we propose an autoencoder-based semi-supervised model which is able to learn a representation of the sensor signal characteristics, also adding an element of interpretability. Main results. Our proposed models are over 8% more accurate than existing feature-based approaches with half the false positive/negative rates. Finally, we show that with careful tuning (that can be improved further), the semi-supervised model outperforms supervised approaches suggesting that incorporating the large amounts of available unlabeled data can be advantageous for achieving high accuracy (over 90%) and minimizing the false positive/negative rates. Significance. Our approach enables us to reliably separate clean from noisy physiological sensor signal that can pave the development of reliable features and eventually support decisions regarding drug efficacy in clinical trials.
Structure of the electron temperature profile around the separatrix
Authors: Díaz Esteban S , Griener M , Wolfrum E , Fischer R , Wendler D , Stieglitz D , Schuster C U , Silvagni D , Zholobenko W , Lackner K , Stroth U ,   the ASDEX Upgrade Team
Published: November 2023

Abstract
The temperature decay length (

λ

T

e

) in the near scrape-off layer (SOL) reflects the ratio between the transport parallel to the magnetic field lines via Spitzer–Härm electron conduction and the perpendicular mechanisms involving neoclassical and anomalous transport. The implementation of the thermal helium beam diagnostic on ASDEX Upgrade has enabled an excellent spatiotemporal study of the structure of the electron temperature profile (

T

e

) around the separatrix and the derivation of the near SOL decay lengths. From the analysis of the

T

e

profile structure of attached H- and L-mode discharges, a self-consistent correspondence between the extrema of the electron temperature curvature profile (

∂

R

2

T

e

) and the position of the separatrix (

R

s
e
p

) is revealed. A 1.5 D model for the power balance from closed to open field lines, including the escaping heat flux from the confined region and the parallel losses to the divertor, as well as results from the plasma edge code GRILLIX, support these experimental results. The evaluation shows that the temperature decay length is not constant over the plasma edge and SOL region, so that the absolute value of

λ

T

e

strongly depends on the analyzed region. Independent of the exact location and in agreement with edge Thomson scattering evaluations, the decay lengths show the known inverse relation to the plasma current (

I

p

).
Experimental investigation into efficiency loss in rotating magnetic field thrusters
Authors: Gill T M , Sercel C L , Jorns B A 
Published: November 2023

Abstract
An experimental investigation into the low thrust efficiency of a rotating magnetic field (RMF) thruster is presented. This technology is a low maturity but potentially enabling candidate for high-power in-space propulsion for use with alternative propellants. Direct thrust stand measurements of a 5 kW class RMF thruster were performed and show the thrust efficiency was 0.41 ± 0.04% with a specific impulse of 292 ± 11 s—typical values for RMF thruster operation. A suite of far-field probes were used to inform a phenomenological efficiency model for RMF thruster performance that accounted for divergence, power coupling, mass utilization, and plasma/acceleration efficiency. It was found that the plasma efficiency was the critically low term at 6.4 ± 1.0%. This indicates that the majority of the energy coupled to the plasma from the RMF antennas was lost before being converted to directed kinetic energy in the thruster beam. To determine the source of these losses, time-resolved measurements of the internal plasma properties were performed using a triple Langmuir probe. It was found that collisional excitation radiation and wall losses were the two dominant loss processes. This trend can be explained by the unusually high plasma density (

>

10

19

m−3) exhibited by this device compared to other electric propulsion architectures. Limitations in the probing techniques and strategies for improving RMF thruster performance are discussed given the results from the efficiency analysis.
Comparative analysis of junctionless and inversion-mode nanosheet FETs for self-heating effect mitigation
Authors: An Do Gyun , Kim Garam , Kim Hyunwoo , Kim Sangwan , Kim Jang Hyun 
Published: November 2023

Abstract
Artificial intelligence computing requires hardware like central processing units and graphic processing units for data processing. However, excessive heat generated during computations remains a challenge. The paper focuses on the heat issue in logic devices caused by transistor structures. To address the problem, the operational mechanism of the Junctionless Field-Effect Transistor (JLFET) is investigated. JLFET shows potential in mitigating heat-related issues and is compared to other nanosheet (ns) FETs. In the case of JL-nsFET, the change in mobility with increasing temperature is smaller compared to Con-nsFET, resulting in less susceptibility to lattice scattering and thermal resistance (Rth) in self-heating effect situation is 0.43 [K µW−1] for Con-nsFET and 0.414 [K µW−1] for JL-nsFET. The reason why the Rth of JL-nsFET is smaller than that of Con-nsFET is that JL-nsFET uses a source heat injection conduction mechanism and a large heat transfer area by using a bulk channel.
PEDOT:PSS based electrospun nanofibres used as trigger for fibroblasts differentiation
Authors: Beregoi Mihaela , Enache Teodor Adrian , Oprea Daniela , Enculescu Monica , Ciobotaru Iulia Corina , Busuioc Cristina , Enculescu Ionut 
Published: November 2023

Abstract
Electrospun nanofibres based on poly(styrene sulfonate) doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS) were fabricated using a straightforward procedure which combines electrospinning, sputtering deposition and electrochemical synthesis. In general, electrospun fibre meshes based on conducting polymers are prepared by mixing the conducting polymer with a carrier polymer or chemically coverage of the fibres. In contrast, freestanding nylon 6/6 nanofibre webs were prepared through electrospinning and were coated by sputtering with gold in order to make them conductive. Further, a PEDOT:PSS layer was electrochemically deposited onto the metalized nanofibre meshes and the synthesis parameters were chosen in such a way to preserve the high active area of the fibres. The prepared material was morphologically characterized and the formation of PEDOT:PSS was also demonstrated. The PEDOT:PSS coated nanofibres revealed remarkable electrical properties (sheet resistance of about 3.5 Ω cm−2), similar to those of metalized nanofibres (sheet resistance around 3 Ω cm2). The in vitro studies using L929 fibroblast mouse cells showed that the bioactive material has no cytotoxic effect and allows proliferation. Moreover, after 72 h of incubation, the fibroblasts shrunk their nuclei and spread suggesting that a differentiation in myofibroblast occurs without application of any kind of external stimuli. These results will be helpful for developing efficient materials for wound healing applications that work without energy consumption.