bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magneto‐Mechano‐Electric Cascade Stimulation System Accelerates Wound Healing Constructed by Biodegradable Magnetoelectric Nanofibers
Authors: Zhang Qian , Zhu Jianhua , Liu Hongmei , Fei Xiang , Zhu Meifang 
Published: November 2023

AbstractReconstructing the intricate biophysical microenvironment to provide multiple biologically beneficial stimulation is deemed a promising therapeutic strategy. However, developing multi‐biophysical stimuli with wireless integration and accurate management remains a formidable challenge. Herein, a novel design of a magneto‐mechano‐electric (MME) cascade stimulation system based on aligned magnetoelectric nanofibrous membranes (PLLA/CFO) is reported. Simply regulating the loading amount of CFO nanoparticles endows the PLLA/CFO membranes with excellent magnetism, enhanced crystallization, and resultant piezoelectric responsiveness, thus providing built‐in topographical guidance and nanoscale magnetic field as well as manageably remote stimulation. Specifically, assisted by an external magnetic field (EMF), the magnetic response in PLLA/CFO can be amplified to offer an apparent deformation, which then induces the output of mechanical and electrical cues. Benefiting from the slow degradability of PLLA and continuous EMF triggering, such a performance can be well modulated to match the practical wound healing process, demonstrated by the repair of a rat full‐thickness skin defect. More importantly, this work offers a new strategy to reconstruct the complex biophysical microenvironment in a wireless remote manner.
Global “Interface‐Space” Dual‐Modulation by Functional Supramolecules Organic Frameworks on Aqueous Zinc‐Ion Batteries
Authors: Fu Meng , Zhao Qiwen , Long Kecheng , Li Quanyu , Kuang Gui‐chao , Zhou Liangjun , Wei Weifeng , Ji Xiaobo , Chen Libao , Chen Yuejiao 
Published: November 2023

AbstractThe uneven zinc‐ion flux and interfacial contact between the anode and electrolyte trigger malignant dendrites and byproducts, significantly hindering the practical application of zinc‐metal batteries. Herein, a H‐bonded supramolecular organic framework (HSOF) is proposed to help regulate Zn2+ flux and stabilize interfacial chemistry. The self‐assembled supermolecule structures by in‐plane H‐bond networks firmly trap water molecules to assist Zn2+ de‐solvation and block interfacial corrosion. The abundant polar groups provide strong guidance for Zn2+ distribution, ensuring homogeneous, and rapid ion transport‐deposition kinetics. Meanwhile, the π–π stacked space‐layout structure affords preferred Zn(002) plane stacking for smooth and flat growth. Benefiting from these advantages, the HSOFs are employed on Zn surface for interfacial adjustment and on separator decoration for spatial manipulation, successfully realizing an overall “interface‐space” dual‐regulation effect. It delivers over 3000 h for the HSOF@Zn anode in symmetric cell and up to 5000 h for HSOF‐decorated separator in Zn||Zn symmetric cell, respectively. The HSOF@Zn||V2O5 full cell with the HSOF‐decorated separator demonstrates enhanced capacity retention of 92.7% after 2500 cycles at 5 A g−1. The full cell can be easily scaled up into a pouch cell, which still has a capacity retention rate of 94% after 1000 cycles.
Schottky Heterojunction Facilitates Osteosarcoma Ferroptosis and Enhances Bone Formation in a Switchable Mode
Authors: Lv Zhongyang , Wu Yizhang , Lin Jintao , Li Weitong , Weisbecker Hannah , Wang Peng , Song Xueru , Sun Wei , Sun Ziying , Xie Ya , Meng Jia , Dong Jian , An Xueying , Chen Jiaqi , Yang Shaoqiang , Yuan Tao , Jiang Hui , Sun Chang , Yang Xiaojiang , Qian Hong , Cai Hongling , Zhao Jianning , Bai Wubin , Shi Dongquan , Bao Nirong 
Published: November 2023

AbstractEffective antitumor agents with concurrent osteogenic properties are essential for comprehensive osteosarcoma (OS) treatment. However, the current clinical therapeutic strategies of OS fail to completely eradicate tumors while simultaneously encouraging bone formation. To address this issue, a switchable strategy for dynamic OS ablation and static bone regeneration is developed by integrating piezoelectric BaTiO3 (BTO) with atomic‐thin Ti3C2 (TC) through a Schottky heterojunction, resulting in the formation of TC@BTO. Under sequential ultrasound and near‐infrared irradiation, the optimized carrier transport of TC@BTO, based on Schottky heterojunction, exhibits excellent characteristics of photothermal conversion and reactive oxygen species generation. This results in ferroptosis of tumor cells and eventual elimination of OS. Moreover, in the static state, the interfacial Schottky heterojunction facilitates the carriers’ directed transfer from the semiconductor to the metal. The Schottky heterojunction‐enhanced static electrical stimulation enhances the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells and repair of bone defects. Furthermore, RNA‐sequencing analysis reveals that static TC@BTO promotes bone regeneration by activating Wnt signaling pathway, and remarkably, pharmacological inhibition of Wnt signaling suppresses the TC@BTO‐induced osteogenesis. Overall, this work broadens the biomedical potential of Schottky heterojunction‐based therapies and provides a comprehensive strategy for overall OS ablation and bone regeneration.
Lab‐on‐a‐Fiber Wearable Multi‐Sensor for Monitoring Wound Healing
Authors: Giovannini Giorgia , Sharma Khushdeep , Boesel Luciano F. , Rossi René M. 
Published: November 2023

AbstractChronic wounds are regarded as a silent epidemic, affecting 1–2% of the population and representing 2–4% of healthcare expenses. The current methods used to assess the wound healing process are based on the visual evaluation of physical parameters. This work aims to design a wearable non‐invasive device capable of evaluating three parameters simultaneously: the pH and the levels of glucose and matrix metalloproteinase (MMP) present in the wound exudate. The device is composed of three independent polymer optical fibers functionalized with fluorescent‐based sensing chemistries specific to the targeted analytes. Each fiber is characterized in terms of detection sensitivity and selectivity confirming their suitability for monitoring the targeted parameters in ranges relevant to the wound environment. The selectivity and robustness of the multi‐sensing device are confirmed with analyses using complex solutions with different pH levels (5, 6, and 7), different concentrations of glucose (1.25, 2.5, and 5 mm), and MMP (1.25, 2.5, and 5 µg mL−1). Given the simple set‐up, the affordability of the materials used and the possibility of detecting additional parameters relevant to wound healing, such multi‐sensing fiber‐based devices could pave the way for novel non‐invasive wearable tools enabling the assessment of wound healing from the molecular perspective.
Self‐Healing Hydrogel Bioelectronics
Authors: Li Zhikang , Lu Jijian , Ji Tian , Xue Yumeng , Zhao Libo , Zhao Kang , Jia Boqing , Wang Bin , Wang Jiaxiang , Zhang Shiming , Jiang Zhuangde 
Published: November 2023

AbstractHydrogels have emerged as powerful building blocks to develop various soft bioelectronics because of their tissue‐like mechanical properties, superior bio‐compatibility, the ability to conduct both electrons and ions, and multiple stimuli‐responsiveness. However, hydrogels are vulnerable to mechanical damage, which limits their usage in developing durable hydrogel‐based bioelectronics. Self‐healing hydrogels aim to endow bioelectronics with the property of repairing specific functions after mechanical failure, thus improving their durability, reliability, and longevity. This review discusses recent advances in self‐healing hydrogels, from the self‐healing mechanisms, material chemistry, and strategies for multiple properties improvement of hydrogel materials, to the design, fabrication, and applications of various hydrogel‐based bioelectronics, including wearable physical and biochemical sensors, supercapacitors, flexible display devices, triboelectric nanogenerators (TENGs), implantable bioelectronics, etc. Furthermore, the persisting challenges hampering the development of self‐healing hydrogel bioelectronics and their prospects are proposed. This review is expected to expedite the research and applications of self‐healing hydrogels for various self‐healing bioelectronics.
Construction of 2D S‐Scheme Heterojunction Photocatalyst
Authors: Zhu Bicheng , Sun Jian , Zhao Yanyan , Zhang Liuyang , Yu Jiaguo 
Published: November 2023

AbstractSemiconductor photocatalytic technology holds immense promise for converting sustainable solar energy into chemically storable energy, with significant applications in the realms of energy and the environment. However, the inherent issue of rapid recombination of photogenerated electrons and holes hinders the performance of single photocatalysts. To overcome this challenge, the construction of 2D S‐scheme heterojunction photocatalysts emerges as an effective strategy. The deliberate design of dimensionality ensures a substantial interfacial area; while, the S‐scheme charge transfer mechanism facilitates efficient charge separation and maximizes redox capabilities. This review commences with a fresh perspective on the charge transfer mechanism in S‐scheme heterojunctions, followed by a comprehensive exploration of preparation methods and characterization techniques. Subsequently, the recent advancements in 2D S‐scheme heterojunction photocatalysts are summarized. Notably, the mechanism behind activity enhancement is elucidated. Finally, the prospects for the development of 2D S‐scheme photocatalysts are presented.
Efficiency Boost in All‐Small‐Molecule Organic Solar Cells: Insights from the Re‐Ordering Kinetics
Authors: Sun Xiaokang , Lv Jie , Wang Fei , Zhang Chenyang , Zhu Liangxiang , Zhang Guangye , Xu Tongle , Luo Zhenghui , Lin Haoran , Ouyang Xiaoping , Yang Chunming , Yang Chuluo , Li Gang , Hu Hanlin 
Published: November 2023

AbstractAchieving high‐performance in all‐small‐molecule organic solar cells (ASM‐OSCs) significantly relies on precise nanoscale phase separation through domain size manipulation in the active layer. Nonetheless, for ASM‐OSC systems, forging a clear connection between the tuning of domain size and the intricacies of phase separation proves to be a formidable challenge. This study investigates the intricate interplay between domain size adjustment and the creation of optimal phase separation morphology, crucial for ASM‐OSCs’ performance. It is demonstrated that exceptional phase separation in ASM‐OSCs’ active layer is achieved by meticulously controlling the continuity and uniformity of domains via re‐packing process. A series of halogen‐substituted solvents (Fluorobenzene, Chlorobenzene, Bromobenzene, and Iodobenzene) is adopted to tune the re‐packing kinetics, the ASM‐OSCs treated with CB exhibited an impressive 16.2% power conversion efficiency (PCE). The PCE enhancement can be attributed to the gradual crystallization process, promoting a smoothly interconnected and uniformly distributed domain size. This, in turn, leads to a favorable phase separation morphology, enhanced charge transfer, extended carrier lifetime, and consequently, reduced recombination of free charges. The findings emphasize the pivotal role of re‐packing kinetics in achieving optimal phase separation in ASM‐OSCs, offering valuable insights for designing high‐performance ASM‐OSCs fabrication strategies.
Robust and Fast‐Ion Conducting Interphase Empowering SiOx Anode Toward High Energy Lithium–Ion Batteries
Authors: Wu Rongxian , Du Xiaofan , Liu Tao , Zhuang Xiangchun , Guan Peng , Zhang Bingqian , Zhang Shenghang , Gao Chenhui , Xu Gaojie , Zhou Xinhong , Cui Guanglei 
Published: November 2023

AbstractSilicon suboxides (SiOx) materials are highly desirable as anode for high energy Li‐ion batteries due to their much higher specific capacity than conventional graphite anode. However, the low initial Coulombic efficiency (ICE) and inadequate capacity retention of SiOx anode arising from its immense volume variation during repeated lithiation/delithiation process greatly hinder its practical applications. To address these drawbacks of SiOx, by a simple calcination method, a robust and fast‐ion conducting interphase enriched of LiF, Li2C2O4, LiBO2, and Li2B4O7 is rationally pre‐constructed With the assistance of this pre‐constructed artificial protective layer, the formed solid‐electrolyte interphase (SEI) layer possesses high Young's modulus and fast Li+ conducting, and thus can accommodate the plastic deformation of SiOx anode, alleviate the parasitic reactions, and maintain the electrode integrity upon cycling. Thus, the modified SiOx (M‐SiOx) anode exhibits higher ICE, better capacity retention and superior rate capability. More encouragingly, full cells pairing the M‐SiOx anode with LiNi0.8Mn0.1Co0.1O2 cathode show a high capacity retention of 80.6% for 200 cycles. This paper reveals the importance of pre‐constructing an artificial SEI layer and regulating interfacial chemistry in improving the performance of SiOx‐based anodes, which is a milestone work for boosting the large scale application of SiOx‐based anodes.
Dendritic sp Carbon‐Conjugated Benzothiadiazole‐Based Polymers with Synergistic Multi‐Active Groups for High‐Performance Lithium Organic Batteries
Authors: Cao Yingnan , Sun Yi , Guo Chaofei , Sun Weiwei , Wu Yang , Xu Yi , Liu Tiancun , Wang Yong 
Published: November 2023

AbstractGreen organic materials composed of C, H, O, and N elements are receiving more and more attention worldwide. However, the high solubility, poor electrical conductivity, and long activation time limit the development of organic materials in practice. Herein, two stable covalent organic materials with alkynyl linkage between benzene rings and benzothiadiazole groups with different amounts of fluorine atoms modification (defined as BOP‐0F and BOP‐2F), are designed for lithium‐ion batteries. Both BOP‐0F and BOP‐2F can achieve superior reversible capacities of ≈719.8 and 713.5 mAh g−1 over 100 cycles on account of the redox activity of alkynyl (two‐electron involved) and benzothiadiazole units (five‐electron involved) in these organic materials. While BOP‐2F electrodes exhibit much more stable cycling performance than BOP‐0F electrodes, especially without pronounced capacity ascending during initial cycling. It can be assigned to the synergy effect of alkynyl linkage and fluorine atom modification in BOP‐2F. The lithium storage and activation mechanism of alkynyl, benzothiadiazole, and fluorine groups have also been deeply probed by a series of material characterizations and theoretical simulations. This work could be noteworthy in providing novel tactics for the molecular design and investigation of high‐efficiency organic electrodes for energy storage.
Modelling and simulation of thermal runaway phenomenon in lithium‐ion batteries
Authors: Alshammari Ali , Al‐Obaidi Mudhar A. , Staggs John 
Published: November 2023

AbstractTo improve the operational time of electronic devices and the driving spectra of electric cars, multiple investigation missions regarding batteries are focussed on refining the energy capacity of batteries. However, this pursuit of better performance introduces potential risks, such as fire incidents, due to the use of dynamic materials in lithium‐ion batteries (LIBs) to enhance their electrochemical performance. These fire incidents have resulted in financial losses and raised safety concerns. One common type of battery failure, called thermal runaway (TR), takes place when the rate of heat discharge from internal chain reactions accelerates the level of external cooling. This study aims to model and comprehensively analyse the phenomenon of TR in LIBs by investigating its underlying physics.To conduct this research systematically, a mathematical framework of heat transfer from existing literature has been employed as a foundation to come up with a novel framework specifically for LIBs built on the ideas of Semenov's equation. The established model associates both thermal and mass balance aspects, with the consideration of response kinetics including other heat transfer modes (convective and radiation). Range–Kutta technique is used to unravel the model's equations instantaneously using MATLAB. Consequently, the impact of model factors on the thermal performance of LIBs has been evaluated. The outcomes of the study reveal that when an increase in activation temperature occurs, a decrease in peak temperature is followed whilst constant circumstances are ensured. This implies that more time is needed in order for the temperature to reach its maximum. Furthermore, the simulation demonstrated that any growth in the body capacity of the battery for absorbing heat during the reaction results in a higher maximum temperature. Heat convection is found to have a greater impact on the occurrence of TR in LIBs compared to heat radiation. For improved accuracy in calculating LIBs TR, an accurate kinetic model could be utilised in future research endeavours.
Analysis of PF6− Anion Intercalation/De‐Intercalation Mechanisms in Graphite Cathodes of Sodium Dual‐Ion Batteries
Authors: Cameán Ignacio , Lobato Belén , Cuesta Nuria , García Ana B. 
Published: November 2023

AbstractA detailed study of the intercalation/de‐intercalation mechanisms of PF6− anions in a graphite cathode of sodium dual‐ion batteries is carried out by cyclic voltammetry. The influence of the continuous anion intercalation/de‐intercalation on the graphite structure is investigated by ex‐situ XRD after cycling. It was concluded that the intercalation/de‐intercalation occurs through a combination of diffusion‐controlled and pseudocapacitive mechanisms. Initially, the contribution of the diffusion‐controlled is significant, specifically at the highest voltage and at the lowest scan rates which agrees with the slow kinetic of this mechanism and its usual prevalence in carbon materials with a graphitic structure. However, the continuous anion intercalation/de‐intercalation causes some deterioration of the graphite structural order, even from the initial cycles, as it was demonstrated by the evolution of the crystalline parameters, interlayer spacing, d002, and crystallite size, Lc. This deterioration hinders the diffusion‐controlled anion intercalation/de‐intercalation and, as a consequence, the pseudocapacitive becomes the main mechanism along cycling. Therefore, since graphite is capable of intercalating PF6− anions at high voltages through a capacitive mechanism, with its consequent rapid kinetics, this carbon material is an excellent candidate for using as cathode in high power sodium dual‐ion batteries, in which, kinetically fast mechanisms are required.
Metal‐free click and bioorthogonal reactions of aggregation‐induced emission probes for lighting up living systems
Authors: Segawa Shinsuke , He Xuewen , Tang Ben Zhong 
Published: November 2023

AbstractIn 2002, two transformative research paradigms emerged: ‘click chemistry’ and ‘aggregation‐induced emission (AIE),’ both leaving significant impacts on early 21st‐century academia. Click chemistry, which describes the straightforward and reliable reactions for linking two building blocks, has simplified complex molecular syntheses and functionalization, propelling advancements in polymer, material, and life science. In particular, nontoxic, metal‐free click reactions involving abiotic functional groups have matured into bioorthogonal reactions. These are organic ligations capable of selective and efficient operations even in congested living systems, therefore enabling in vitro to in vivo biomolecular labelling. Concurrently, AIE, a fluorogenic phenomenon of twisted π‐conjugated compounds upon aggregation, has offered profound insight into solid‐state photophysics and promoted the creation of aggregate materials. The inherent fluorogenicity and aggregate‐emission properties of AIE luminogens have found extensive application in biological imaging, characterized by their high‐contrast and photostable fluorescent signals. As such, the convergence of these two domains to yield efficient labelling with excellent fluorescence images is an anticipated progression in recent life science research. In this review, we intend to showcase the synergetic applications of AIE probes and metal‐free click or bioorthogonal reactions, highlighting both the achievements and the unexplored avenues in this promising field.
Using eDNA to survey amphibians: Methods, applications, and challenges
Authors: Sun Xiaoxuan , Guo Ningning , Gao Jianan , Xiao Nengwen 
Published: November 2023

AbstractIn recent years, environmental DNA (eDNA) has received attention from biologists due to its sensitivity, convenience, labor and material efficiency, and lack of damage to organisms. The extensive application of eDNA has opened avenues for the monitoring and biodiversity assessment of amphibians, which are frequently small and difficult to observe in the field, in areas such as biodiversity survey assessment and detection of specific, rare and threatened, or alien invasive species. However, the accuracy of eDNA can be influenced by factors such as ambient temperature, pH, and false positives or false negatives, which makes eDNA an adjunctive tool rather than a replacement for traditional surveys. This review provides a concise overview of the eDNA method and its workflow, summarizes the differences between applying eDNA for detecting amphibians and other organisms, reviews the research progress in eDNA technology for amphibian monitoring, identifies factors influencing detection efficiency, and discusses the challenges and prospects of eDNA. It aims to serve as a reference for future research on the application of eDNA in amphibian detection.
Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice
Authors: Qiu Dan , Liu Tong , Qianping Wei 
Published: November 2023

AbstractObjectiveThis study aimed to explore the molecular mechanism underlying the role of Pin1 in cognitive dysfunction in diabetic mice.MethodsUsing a streptozotocin‐induced diabetic mouse model, an adeno‐associated virus carrying the Pin1 gene was used to upregulate Pin1 expression in the hippocampus of diabetic mice. Animal behavior tests and molecular biology techniques were further used to explore the role of Pin1 in cognitive dysfunction in diabetic mice.ResultsOur study demonstrated that upregulation of Pin1 expression increased the phosphorylation of AKT and insulin receptor substrate 1 downstream signaling molecules of the IR‐IGF1R pathway, increased the phosphorylation of GSK‐3β, and concomitantly decreased the phosphorylation of Tau in the hippocampus of diabetic mice, thereby improving the ultrastructural pathology of the hippocampus and further alleviating diabetes‐related cognitive impairment.ConclusionPin1 can improve cognitive dysfunction in diabetic mice.