bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural Network Estimators for Optimal Tour Lengths of Traveling Salesperson Problem Instances with Arbitrary Node Distributions
Authors: Varol Taha , Özener Okan Örsan , Albey Erinç 
Published: December 2023

It is essential to solve complex routing problems to achieve operational efficiency in logistics. However, because of their complexity, these problems are often tackled sequentially using cluster-first, route-second frameworks. Unfortunately, such two-phase frameworks can suffer from suboptimality due to the initial phase. To address this issue, we propose leveraging information about the optimal tour lengths of potential clusters as a preliminary step, transforming the two-phase approach into a less myopic solution framework. We introduce quick and highly accurate Traveling Salesperson Problem (TSP) tour length estimators based on neural networks (NNs) to facilitate this. Our approach combines the power of NNs and theoretical knowledge in the routing domain, utilizing a novel feature set that includes node-level, instance-level, and solution-level features. This hybridization of data and domain knowledge allows us to achieve predictions with an average deviation of less than 0.7% from optimality. Unlike previous studies, we design and employ new instances replicating real-life logistics networks and morphologies. These instances possess characteristics that introduce significant computational costs, making them more challenging. To address these challenges, we develop a novel and efficient method for obtaining lower bounds and partial solutions to the TSP, which are subsequently utilized as solution-level predictors. Our computational study demonstrates a prediction error up to six times lower than the best machine learning (ML) methods on their training instances and up to 100 times lower prediction error on out-of-distribution test instances. Furthermore, we integrate our proposed ML models with metaheuristics to create an enumeration-like solution framework, enabling the improved solution of massive-scale routing problems. In terms of solution time and quality, our approach significantly outperforms the state-of-the-art solver, demonstrating the potential of our features, models, and the proposed method. History: This paper has been accepted for the Transportation Science Special Issue on Machine Learning Methods and Applications in Large-Scale Route Planning Problems. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2022.0015 .
Karl Löwith e o problema do decisionismo em Carl Schmitt
Authors: Lima Deyvison Rodrigues 
Published: December 2023

O artigo analisa a leitura de Karl Löwith sobre o decisionismo ocasionalista de Carl Schmitt. A pergunta elementar é, afinal, por qual fundamento é constituída a ordem política? A interpretação de Löwith sobre Schmitt assume a estrutura do argumento de Leo Strauss acerca do Der Begriff des Politischen e afirma de modo mais incisivo que a pulsão da Entscheidung für die nackte Entschiedenheit (decisão pelo mero ser-decidido) é estrutura básica do argumento schmittiano, caracterizando um ocasionalismo político. Entre o debate em torno do teorema da secularização, das interpretações sobre a teologia política e a imagem especular da indecisão romântica, a leitura de Löwith ressalta a irracionalidade e o niilismo como consequências das teses de Schmitt, características que o jurista acusava ser próprias do liberalismo e do romantismo. A conclusão indica que a contingência, como a principal característica da modernidade política, provoca a tensão entre o apelo do jurista à decisão pela ordem e a interpretação do filósofo da ausência de fundamentação normativa do direito.
DILEMAS BIOÉTICOS ENTRE A CIÊNCIA, O DIREITO E A RELIGIÃO
Authors: Hogemann Edna Raquel 
Published: December 2023

Propõe um refletir sobre o processo histórico de monopólio e laicização do conhecimento na sociedade ocidental, tendo em conta que a Igreja Católica Apostólica Romana sempre ocupou uma posição universalista ao longo da História. Aborda essa influência e suas consequências na Bioética, principalmente em medidas de controle social e nas políticas de saúde. Enfoca, em especial as questões de política reprodutiva.O artigo está dividido em quatro momentos: a proposta do ensaio que pensa na religião como instrumento de controle e manutenção da ordem social, a relação existente entre crença religiosa e medicina, uma breve passagem sobre a base teórica e metodológica que possibilita uma análise da questão sob o enfoque bioético, e um olhar sobre alguns casos concretos ilustradores da temática do ensaio.
PLAN B EARTH AND OTHERS vs SECRETARY OF STATE FOR TRANSPORT
Authors: Setzer Joana , Rossi Lívia Trabulsi , Gueorguiev Maria Christina M. 
Published: December 2023

O presente artigo analisa um caso de litigância climática emblemático envolvendo a ampliação do aeroporto de Heathrow: a ação R (on the application of Plan B Earth) v Secretary of State for Transport (the Court of Appeal Judgment), proposta em agosto de 2018 pela organização de interesse público (charity) britânica Plan B Earth(ou “Plan B”). O estudo tem por objetivo discutir o caso e como o precedente pode ser entendido no contexto brasileiro. Para tanto, o trabalho é dividido em quatro partes: (1) a conjuntura social, política e econômica do Reino Unido; (2) o sistema jurídico britânico; (3) os argumentos jurídicos articulados pelas partes e pelas cortes; e (4) a potencial relação do caso com a realidade brasileira.
Oral and dental conditions in winetasters and others in the wine trade
Authors: Overgaard-Nielsen Henrik , Wilson Sir Nairn HF 
Published: December 2023

Oral and dental problems may be considered to be an occupational hazard of winetasters and others in the wine trade. These oral and dental problems are reviewed. Advice to members of the wine trade to prevent occupational oral and dental problems is presented, together with views on the management of such problems. CPD/Clinical Relevance: Oral and dental conditions may be an occupational hazard among winetasters and others in the wine trade.
A novel approach for the placement of zygomatic implants: the zygomatic bone zone index
Authors: George Pynadath 
Published: December 2023

This article explores the considerations and factors that implant dentists may use to decide whether the placement of zygomatic implants is necessary, and if so, the potential considerations in planning for them within the zygomatic bone. A novel treatment planning tool has been presented, the Zygomatic Bone Zone index, to improve the surgical placement of zygomatic implants, to help reduce complications and to allow for further placement within the zygomatic bone in the future. CPD/Clinical Relevance: It is important for clinicians to be aware of treatment modalities that might be of benefit to some patients.
The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development
Authors: Chen Mei-Feng , Hu Chih-Chien , Hsu Yung-Heng , Lin Yu-Chih , Chen Kai-Lin , Ueng Steve W. N. , Chang Yuhan 
Published: December 2023

AimsTherapeutic agents that prevent chondrocyte loss, extracellular matrix (ECM) degradation, and osteoarthritis (OA) progression are required. The expression level of epidermal growth factor (EGF)-like repeats and discoidin I-like domains-containing protein 3 (EDIL3) in damaged human cartilage is significantly higher than in undamaged cartilage. However, the effect of EDIL3 on cartilage is still unknown.MethodsWe used human cartilage plugs (ex vivo) and mice with spontaneous OA (in vivo) to explore whether EDIL3 has a chondroprotective effect by altering OA-related indicators.ResultsEDIL3 protein prevented chondrocyte clustering and maintained chondrocyte number and SOX9 expression in the human cartilage plug. Administration of EDIL3 protein prevented OA progression in STR/ort mice by maintaining the number of chondrocytes in the hyaline cartilage and the number of matrix-producing chondrocytes (MPCs). It reduced the degradation of aggrecan, the expression of matrix metalloproteinase (MMP)-13, the Osteoarthritis Research Society International (OARSI) score, and bone remodelling. It increased the porosity of the subchondral bone plate. Administration of an EDIL3 antibody increased the number of matrix-non-producing chondrocytes (MNCs) in cartilage and exacerbated the serum concentrations of OA-related pro-inflammatory cytokines, including monocyte chemotactic protein-3 (MCP-3), RANTES, interleukin (IL)-17A, IL-22, and GROα. Administration of β1 and β3 integrin agonists (CD98 protein) increased the expression of SOX9 in OA mice. Hence, EDIL3 might activate β1 and β3 integrins for chondroprotection. EDIL3 may also protect cartilage by attenuating the expression of IL-1β-enhanced phosphokinase proteins in chondrocytes, especially glycogen synthase kinase 3 alpha/beta (GSK-3α/β) and phospholipase C gamma 1 (PLC-γ1).ConclusionEDIL3 has a role in maintaining the cartilage ECM and inhibiting the development of OA, making it a potential therapeutic drug for OA.Cite this article: Bone Joint Res 2023;12(12):734–746.
Fast 3D positioning based on a simplified THz photonic stereo ISAR system
Authors: Yang Zuomin , Zhang Hongqi , Lyu Zhidong , Yang Hang , Zhang Lu , Zhao Hangbin , Li Feng , Zhang Changming , Yu Xianbin 
Published: December 2023

In this work, a THz stereo inverse synthetic aperture radar scheme based on photonics is proposed, and proof-of-concept experimentally demonstrated, achieving high resolution and fast three-dimensional (3D) positioning of multiple targets. An optical frequency comb and a uni-traveling carrier photodiode are employed to photonically generate a linear frequency-modulation signal at 300–320 GHz. By two incoherent measurements at different angles with one pair of antennas, 3D positioning of plane reflectors over a distance of 0.6 m is successfully accomplished, achieving a resolution of 7.5 mm for both range and azimuth dimensions, and a maximum experimental height error of 4 mm.
Making the BEST decision-the BESTa project development, implementation and evaluation of a digital Decision Aid in Swedish cancer screening programmes- a description of a research project
Authors: Fritzell Kaisa , Hedberg Berith , Woudstra Anke , Forsberg Anna , Sventelius Marika , Kottorp Anders , Jervaeus Anna 
Published: December 2023

BackgroundSweden has a long tradition of organized national population-based screening programmes. Participation rates differ between programmes and regions, being relatively high in some groups, but lower in others. To ensure an equity perspective on screening, it is desirable that individuals make an informed decision based on knowledge rather than ignorance, misconceptions, or fear. Decision Aids (DAs) are set to deliver information about different healthcare options and help individuals to visualize the values associated with each available option. DAs are not intended to guide individuals to choose one option over another. The advantage of an individual Decision Aid (iDA) is that individuals gain knowledge about cancer and screening by accessing one webpage with the possibility to communicate with health professionals and thereafter make their decision regarding participation. The objective is therefore to develop, implement and evaluate a digital iDA for individuals invited to cancer screening in Sweden.MethodsThis study encompasses a process-, implementation-, and outcome evaluation. Multiple methods will be applied including focus group discussions, individual interviews and the usage of the think aloud technique and self-reported questionnaire data. The project is based on The International Patient Decision Aid Standards (IPDAS) framework and the proposed model development process for DAs. Individuals aged 23–74, including women (the cervical-, breast- and CRC screening module) and men (the CRC screening module), will be included in the developmental process. Efforts will be made to recruit participants with self-reported physical and mental limitations, individuals without a permanent residence and ethnic minorities.DiscussionTo the best of our knowledge, the present study is the first attempt aimed at developing an iDA for use in the Swedish context. The iDA is intended to facilitate shared decision making about participation in screening. Furthermore, the iDA is expected to increase knowledge and raise awareness about cancer and cancer screening.Patient or public contributionLay people are involved throughout the whole development and implementation process of the digital DA.Trial registrationNCT05512260.
La inclusión en Educación Primaria a través del movimiento y la danza
Authors: Guillén García Marina 
Published: December 2023

El arduo recorrido hacia la inclusión supone uno de los objetivos esenciales para la educación actual, por ello, el presente artículo plantea una intervención didáctica para quinto de Primaria cuya finalidad consiste en la búsqueda de la inclusión en un grupo-clase a través de tres sesiones, cada una dirigida a una rama específica de la misma que fomente el respeto y la tolerancia hacia el grupo de iguales, personas con diversidad funcional y de otras culturas.
Su puesta en práctica se ha llevado a cabo en un Colegio Público de Infantil y Primaria de la Región de Murcia. El hilo conductor de dicha propuesta se enfoca en el movimiento y la danza, debido a las posibilidades inclusivas que presentan.
Las conclusiones obtenidas de este estudio suponen destacar el papel crucial de la danza como elemento de acercamiento entre personas diversas. La música, como lenguaje universal, demostró ser un puente efectivo entre diferentes culturas y capacidades, contribuyendo al logro de los objetivos propuestos. En la discusión de los resultados, se enfatiza la importancia de no abordar estas sesiones de forma aislada, sino de integrar de manera continua la visibilización de realidades ajenas en esta etapa educativa.
Las mujeres en el aula de música. Actividades para desarrollar en el aula
Authors: Dobon Chic Claudia 
Published: December 2023

Actualmente la desigualdad de género es una realidad que afecta de manera directa al mundo de la música. La presencia de mujeres en los diferentes ámbitos musicales como las orquestas, la composición o la dirección es minoritaria. A pesar de que el porcentaje de mujeres va aumentando con el paso del tiempo, es fundamental seguir trabajando en la visibilización y empoderamiento para alcanzar la igualdad. Por esta razón, los objetivos de este artículo son resaltar la presencia de las mujeres relacionadas con la música y concienciar al alumnado de la desigualdad que siguen sufriendo las mujeres a día de hoy. Para ello, hemos diseñado tres actividades puntuales. Concluimos que la educación es una herramienta fundamental en el progreso hacia la igualdad de género, para conseguir un nivel de concienciación elevado entre el alumnado.
Динамика смысложизненных установок россиян и консолидационного потенциала общества
Authors: Седова Наталья Николаевна 
Published: December 2023

В конце 2023 г. в Институте социологии ФНИСЦ РАН под редакцией М.К. Горшкова и Н. Е. Тихоновой выходит коллективная монография «Российское общество и вызовы времени. Книга седьмая», посвященная трансформации духовно-психологических, мировоззренческих и иных компонентов массового сознания россиян, а также их влиянию на консолидацию общества в современных условиях. Журнал «Мониторинг общественного мнения: экономические и социальные перемены» публикует фрагмент главы этой книги, в фокусе внимания которого находятся смысложизненные установки, нормы и ценности россиян, характер их динамики на протяжении последних двадцати лет. Представленный фрагмент содержит анализ динамики установок на традиции и различных показателей агентности россиян — восприятия себя как самодостаточных или зависимых от государства, внешнего/внутреннего локуса контроля, готовности к борьбе за свои права — в их связи с проблематикой ценностного раскола в современном российском обществе и развития потенциала общественной консолидации.
С опорой на данные многолетних исследований Института социологии ФНИСЦ РАН делается вывод о росте ценности традиций в российском обществе и о новом их прочтении в свете противостояния России с Западом, стремления присоединиться к консолидированному большинству. Одновременно отмечается невысокая консистентность показателей, характеризующих готовность брать на себя ответственность и бороться за свои интересы, выбор между личными и общественными интересами, установки на «идеальную демократию» или «сильное государство». Все это может ослаблять генеральный тренд общественно-политической консолидации.
Благодарность. Материал подготовлен при поддержке РНФ, проект № 20-18-00505 «Влияние нематериальных факторов на консолидацию российского общества в условиях новых социокультурных вызовов и угроз» (руководитель — д. филос. н., академик РАН М. К. Горшков).
Incidence of different pressure patterns of spinal cerebellar ataxia and analysis of imaging and genetic diagnosis
Authors: Peng Yufen , Tu Qi , Han Yao , Gao Liang , Wan Chenyi 
Published: December 2023

Abstract
Neurologists have a difficult time identifying sporadic cerebellar ataxia. Multiple system atrophy of the cerebellar type (MSA-C), spontaneous late cortical cerebellar atrophy, and prolonged alcohol use are a few possible causes. In a group of people with sporadic cerebellar ataxia that was not MSA-C, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was recently discovered. Chinese single-hospital cohort will be used in this study to genetic screen for SCA-related genes. One hundred forty individuals with CA were monitored over 8 years. Thirty-one individuals had familial CA, 109 patients had sporadic CA, 73 had MSA-C, and 36 had non-MSA-C sporadic CA. In 28 of the 31 non-MSA-C sporadic patients who requested the test, we carried out gene analysis, including SCA1, SCA2, SCA3, SCA6, SCA7, SCA8, SCA12, SCA17, SCA31, and dentatorubro-pallidoluysian atrophy (DRPLA). The control group consisted of family members of the patients. In 57% of the instances with spontaneous CA that were not MSA-C, gene abnormalities were discovered. The most frequent exception among individuals with sporadic CA was SCA6 (36%), followed by monsters in SCA1, 2, 3, 8, and DRPLA. In contrast, 75% of the patients with familial CA had gene abnormalities, the most frequent of which was SCA6 abnormality. The age of 69 vs 59 was higher, and the CAG repeat length was a minor age of 23 vs 25 in the former instances compared to the last one among individuals with SCA6 anomalies that were sporadic as opposed to familial cases. In sporadic CA, autosomal-dominant mutations in SCA genes, notably in SCA6, are common. Although the cause of the increased incidence of SCA6 mutations is unknown, it may be related to a greater age of onset and varied penetrance of SCA6 mutations.
Clinicopathological characteristics of co-existing or mixed colorectal cancer and neuroendocrine tumor: Report of five cases
Authors: Zhang Ling , Wang Xiaoling , Wang Yun , Zeng Yan , Li Li 
Published: December 2023

Abstract
Coexisting or mixed type of colorectal tumors has been rarely reported. This study was designed to investigate clinicopathological characteristics of co-existing or mixed colorectal adenocarcinoma and highly differentiated neuroendocrine tumor (NET-G1). To do that, clinicopathological characteristics of five cases of co-existing or mixed colorectal adenocarcinoma and NET-G1 admitted to our institution between 2017 and 2021 were retrospectively analyzed and literature review was conducted. Four patients were male and one female, aged 62–75 years old. Among them, four cases were diagnosed with rectal cancer and one case of colon cancer. Gross examination found that one patient was diagnosed with multiple colon polyps including three malignant polyps, and the remaining four cases of ulcerous masses. The tumors infiltrated into the muscle layer in two cases, and three cases with tumors infiltrating into surrounding adipose tissues. Microscopic examination revealed one patient developed poorly differentiated adenocarcinoma and four cases of moderately differentiated adenocarcinoma. Four patients had adenocarcinoma and NET-G1 in colon, and one case of adenocarcinoma in colon and NET-G1 in appendix. To conclude, co-existing or mixed colorectal tumors are extremely rare in clinical settings. Clinicopathological characteristics of five cases of co-existing or mixed adenocarcinoma and NET-G1 are diverse and adenocarcinoma is more aggressive in most affected patients.
From screen to bench: unpacking the shifts in chemistry learning experiences during the COVID-19 transition
Authors: Ramadhani Dimas Gilang , Yamtinah Sri , Saputro Sulistyo , Sarwanto Sarwanto , Masykuri Mohammad 
Published: December 2023

Abstract
This research comprehensively analyzes students’ Chemistry Learning Experience (CLE) during the COVID-19 pandemic, comparing online learning experiences with traditional face-to-face instruction in the post-pandemic phase. Employing a quantitative approach and leveraging the Rasch model, the study focuses on capturing the nuances of individual student perceptions, an aspect often overlooked in group-centric statistical analyses. One hundred students (49 males and 51 females) participated in both study phases. Segmented into behavioral tendencies, content perceptions, and specific learning needs, the evaluation tools provided insights into the students’ CLE across the two instructional modalities. Results from the stacking analysis revealed a positive shift in CLE post-pandemic, with students demonstrating a better grasp of and attitude toward chemistry in face-to-face settings. Racking analysis further underscored the changing difficulty perceptions of specific content items across the two learning environments. Gender-based patterns in CLE were also evident, with male students expressing a more favorable view of online learning during the pandemic than their female counterparts. The research findings advocate for a blended learning approach, harnessing the strengths of both online and traditional instructional methods. Furthermore, insights into gender-specific learning experiences emphasize the need for inclusive and adaptive teaching strategies, ensuring optimal learning experiences for all students. The study underscores educators’ and students’ resilience and adaptability in navigating the challenges of the pandemic. It offers valuable insights for future educational strategies in chemistry education.