bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF MEMANTINE AS N-METHYL D-ASPARTATE RECEPTOR ANTAGONIST ON CASPASE-9 LEVEL OF RETINAL GANGLION CELL IN METHANOL TOXIC OPTIC NEUROPATHY RAT MODEL
Authors: ANTONIA KARTIKA  , Rusti Hanindyasari  , Dianita Veulina Ginting  , Pretyllayolamada  
Published: February 2024

Abstract
Introduction & Objectives : Methanol toxic optic neuropathy (MTON) remains as a health issue in developing countries and there are no current definitive treatments. Accumulation of formic acid as metabolite of methanol causes mitochondrial dysfunction that can reduce ATP synthesis rate, disrupt axoplasmic transport, and elevate the reactive oxygen species (ROS). All of these mechanisms lead to the death of retinal ganglion cell (RGC) and optic nerve. RGC destruction in MTON has similar patterns with those that have been observed in glaucoma, ischemia, and trauma cases, that is through excessive activation of glutamate neurotransmitter via N-Methyl D-Aspartate receptors (NMDAR). Memantine is a NMDAR antagonist that inhibit the ion channel of NMDAR. This inhibitory effect of NMDAR by memantine is expected to reduce intracellular calcium level, prevent apoptosis of RGC, and prevent further mitochondrial dysfunction. Caspase-9 is essential to eliminate cells by executing apoptotic Objective: To observe the effect of Memantine on Caspase-9 level of RGC in Methanol-Intoxicated Rats.
Methods : This experimental study was performed on 28 Methanol-Intoxicated Rats that are assigned into four treatment groups: K1 (MTON;enucleated day-3), K2 (MTON+Memantine; enucleated day-3), K3 (MTON; enucleated day-7), and K4 (MTON+Memantine; enucleated day-7). During the experiment, all groups were exposed to N2O:O2 gas and were given methanol orally. Caspase-9 level of RGC were measured immediately after enucleation.
Results : The average of Caspase-9 level (ng/ml): K1=197,88±33,98; K2=205,64±63,66; K3=243,15±40,13; K4=150,08±119,60. The Caspase-9 level was significantly lower in K4 compared to K3 (p value =0.038).
Conclusion : Memantine decrease the level of Caspase-9 of RGC in Methanol Toxic Optic Neuropathy rat model.
Gelatinous Drop-Like Corneal Dystrophy in an Acehnese Family: Serial Cases.
Authors: Samira Cut Putri , Akbar Muhammad Khalil 
Published: February 2024

Introduction : Gelatinous drop-like dystrophy (GDLD) is a rare type of corneal dystrophy with an autosomal recessive inheritance pattern. Although the prevalence in Japan is approximately 1 in 33,000, it is much less common in other nations. Lamellar or penetrating keratoplasty is needed for most patients to alleviate the symptoms. This case series aims to provide knowledge regarding rare cases of GDLD and its management.
Case Illustration : Three male siblings from consanguineous marriage were found to have corneal dystrophy, characterized by a white-yellow nodular lesion with a kumquat-like appearance on the corneal surface. The visual acuity of each patient was light perception with good projection. To treat the condition, all patients underwent full-thickness penetrating keratoplasty. One month after the procedure, their visual acuity had improved to 3/60, 2/60, and 2/60, respectively.
Discussion : GDLD is a genetic disease with gelatinous amyloid deposits in the cornea that typically manifests within the first decades of life. GDLD can present in three different phenotypes, including band keratopathy, mulberry, and kumquat-like appearance. In the case of these siblings, they have developed the severe kumquat-like phenotype. Detection by examining family involvement and the cornea's clinical presentation can help diagnose GDLD. Full-thickness penetrating keratoplasty can be an option for managing severely impaired visual acuity caused by GDLD.
Conclusion : GDLD is a rare corneal dystrophy that can lead to severe visual impairment. The objective of treating GDLD is to enhance vision and prevent its progression. Vision loss can be alleviated througha surgical procedure such as full-thickness penetrating keratoplasty.
CHARACTERISTICS AND MANAGEMENT OF PEDIATRIC CATARACT AT UNIVERSITAS TANJUNGPURA HOSPITAL 2019-2021
Authors: MUHAMMAD ASRORUDDIN  , WIWIK WINDARTI  , YESSLYN YULIANTO  
Published: February 2024

Abstract
Introduction & Objectives : One of the causes of blindness in children that can be treated is cataracts. The prevalence of childhood cataracts in Asia is the highest in the world at 7.43 per 10,000 children. There were 4,270 children in Indonesia who experienced blindness due to cataracts in 2017. Data on childhood cataracts in West Kalimantan is still limited. However, the prevalence of blindness in West Kalimantan is the highest in Indonesia at 1.6%. Characteristics of pediatric cataract patients need to be known to assist in diagnosis and treatment so that the risk of blindness in children can be prevented. This study is to describe cataracts in children at Universitas Tanjungpura Hospital in 2019-2021.
Methods : This study used a cross-sectional descriptive design. Data collection was obtained from the medical records of pediatric cataract patients at the Universitas Tanjungpura Hospital during 2019-2021.
Results : The total number of pediatric cataract patients obtained from medical records during 2019-2021 was 27 patients, consisting of 8 girls and 19 boys. Congenital cataracts were the most common cataracts (59%) and the most diagnosed age was in the 0-1 year group. Bilateral cataracts (48%) were almost as numerous as unilateral cataracts (52%). The most common visual acuity before and after surgery was fixating and following object (60%).
Conclusion : Cataracts in children at Universitas Tanjungpura Hospital in 2019-2021 were dominated by congenital cataracts, diagnosis age was at 0-1 years, bilateral and unilateral, male gender, and visual acuity before and after surgery was fixating and following object.
Monocular Electrical Cataract: A Case Report
Authors: Ey Merry Giovedi , Dewanto Erry , Prastayani Reni 
Published: February 2024

Introduction : An electric shock is experienced when an electric current passes through a part of the body from an entry point to an exit point. Cataract is frequently described as a complication of electrical injury and it is usually bilateral. We report a rare case of high voltage electric injury in young male patient resulting in monocular cataract.
Case Illustration : A 23 years old man was presented with a diminution of vision one year after sustaining an overhead high voltage power transmission wire that stung his head. The visual acuity of the right eye was hand movement dan 1.0 in the left eye. On slit-lamp examination, opacities were presented in the lens of the right eye and a clear lens in the left eye. Being diagnosed as having monocular cataract, the patient was then performed phacoemulsification on his right eye (April 12th 2023). The pupil shrank until 5 mm during the surgery but foldable IOL was successfully inserted in the capsule. The right eye vision was improved to 0.5 one day after surgery.
Discussion : The consequences of high-voltage electric burns are complex. Electrical shock can cause protein coagulation and cataract formation. Lens manifestations are more likely when the transmission of current involves the patient’s head. Proper management of electrical cataracts will result in good visual rehabilitation if the eye does not suffer additional damage as in this case.
Conclusion : Secondary cataract formation due to electric injury may occur, therefore routine examinations with the ophthalmologist are needed after the electrical trauma. The incidence of monocular cataracts after the electric injury is rare.
Prostaglandin analogs regimen for open-angle glaucoma or hypertensive ocular, is it still effective nowadays?: a systematic review
Authors: Tikha Fidya Ainun , Rahadi Aditia Rizka 
Published: February 2024

Introduction & Objectives : Open-angle glaucoma and hypertensive ocular therapy are still developing. There are new medications that offer fast and safe in lowering intraocular pressure. Prostaglandin analogs regimenis a well-known medication that we use in lowering intraocular pressure and still use in this era.
Methods : A literature search was performed in PubMed, Chocraine, and Google Scholar for studies that fit our inclusion criteria. The Literature must be Randomized controlled trials, Systematic reviews, and meta-analyses from 2013 until 2023 that report data on prostaglandin analogs regimen uses medications for open-angle glaucoma or ocular hypertension. That consists of data on intraocular pressure (IOP) lowering effect by the use of prostaglandin analogs regimen monotherapy or combination.
Results : We included Ten literature that consists 5 RCTs (1514 participants), and 5 systematic reviews with meta-analysis (235 RCT literature), that overall make intraocular pressure (IOP) reduction. There are differences in duration to reduce IOP between prostaglandin analogs regimen types and combinations with other classes of regimen.
Conclusion : prostaglandin analogs regimen effective in IOP lowering effect in open-angle glaucoma and hypertensive ocular both monotherapy and combination.
BARRAGE LASER PHOTOCOAGULATION IN HIGH-MYOPIC PATIENT WITH SYMPTOMATIC RETINAL TEARS BEFORE PHACOEMULSIFICATION: A CASE REPORT
Authors: Budhiastra I Putu , Tridiyoga Komang Putra , Jayanegara I wayan Gede , Suryathi Ni Made Ari , Andayani Ari , Pitanatri Nyoman Brahmani 
Published: February 2024

Introduction : Retinal tears can be present in up to 2.4% of cases of lattice degeneration, which is considered an important risk of retinal detachment in a high-myopic patient. Laser photocoagulation has been shown to reduce the risks of retinal detachment before phacoemulsification thus improve in the visual outcome. We report a case of a high myopic patient with symptomatic retinal tears who underwent phacoemulsification that was treated prophylactically with barrage laser photocoagulation.
Case Illustration : A 43 years-old female with a history of high myopia complained of flashes and floaters on both eyes. She had high myopia measuring -13.0 dioptres and -28.0 dioptres in the right and left eyes respectively. Unaided visual acuity was 2/60 in both eyes. Fundus examination showed lattice degenerations with a small tear found on both eyes with no retinal detachments. She was treated with a barrage laser on both eyes followed by phacoemulsification. On the last follow-up, the retina remained stable and the visual acuity was significantly improved with no development of macular edema or retinal detachment in both eyes.
Discussion : Although most cases of lattice degeneration do not need intervention, some present a risk of retinal detachment. Barrage laser photocoagulation may have a place in high myopic patient lattice degeneration with symptomatic retinal tears to maintain retinal stability and to obtain the optimal outcome after phacoemulsification.
Conclusion : Barrage laser photocoagulation is beneficial as a prophylactic treatment of symptomatic retinal tears before phacoemulsification in high-myopic patients.
C-Reactive Protein as a Prognostic Indicator: Navigating the Challenge of Predicting Severity and Mortality in Acute Pancreatitis
Authors: Rahman Ibadur , Saleem Hira , Muhammad Burhan ul Haq  , Muhammad Adnan Khokhar  , Arif Khurshid  , Zulfiqar Khan Tanoli  , Shaharyar Ahsan  
Published: February 2024

Objective: The main goal was to evaluate the effectiveness of C-reactive protein (CRP) in assessing acute pancreatitis severity 48 hours after onset by contrasting its results with CT scans.
Methodology: This cross-sectional study, which lasted six months from May to December 2019 at the Department of General Surgery, Pakistan Institute of Medical Sciences, comprised 150 suspected cases. CT scans and serum samples were taken 48 hours after the onset of symptoms. A postgraduate trainee created reports using a standard proforma to record CT scan results and CRP levels.
Results: The average age of the patients was 45.03±10.86 years, with severe acute pancreatitis confirmed in 28.7% of cases by CT scans. CRP demonstrated notable diagnostic values: sensitivity 81.4%, specificity 92.52%, PPV 81.4%, NPV 92.52%, and an overall accuracy of 89.33%.
Conclusion: C-reactive protein (CRP), a product of interleukin-1 and interleukin-6 responses by the liver, emerges as a valuable and cost-effective biomarker. Its consistent elevation in correlation with pancreatitis severity, especially within the critical 48-hour window, suggests its potential as a reliable predictor. This study underscores CRP's diagnostic utility and accessibility, emphasizing its role in assessing acute pancreatitis severity.

Key Words: C-reactive protein, CT scan, Acute pancreatitis
Dependence of sensitivity loss on organic film thickness and influence of cantilever warpage in a piezoelectric wideband acoustic sensor coated with an organic film
Authors: Kuchiji Hiroyuki , Masumoto Naoki , Morishita Kota , Hasegawa Shunta , Suzuki Takaaki , Baba Akiyoshi 
Published: February 2024

Abstract
A wideband acoustic sensor is reported, comprising a piezoelectric MEMS acoustic transducer with organic film-coated cantilevers. Considering the sensitivity reduction associated with the application of an organic film, it is necessary to optimize the material selection and thickness of the organic film. Therefore, the relationship between the thickness of the polyurethane film and the consequent loss in sensitivity is elucidated. Our findings demonstrate that the polyurethane film thickness should be approximately 0.5 μm (or less) to limit sensitivity loss to 6 dB. Additionally, both simulations and experimental results reveal that the resonant frequency of the system is significantly influenced by the warpage of the cantilever. This study provides essential insights into optimizing the performance of MEMS acoustic transducers with organic film-coated cantilevers.
INFLUÊNCIA DOS ÓLEOS ESSENCIAIS NA MELHORIA DO SONO: UMA REVISÃO CIENTÍFICA
Authors: Silva Thainara Pereira da , Cunha Ítalo íris Boiba Rodrigues da , Lima Jefferson  Raimundo de Almeida , Figueiredo Kaísa Lindomara dos Santos , Chaves Fabiola Gondim Medeiros , Souza Thaiana de , Alencar Itiel Elanã Soares , Silveira Maitê Bonfim Nogueira , Junior Sandoval Fernando Cardoso de Freitas , Freitas Sara Regina Moura de , Mendes Pedro Afonso Ribeiro , Mendonça Lívia Cruz de 
Published: February 2024

A qualidade do sono desempenha um papel fundamental na promoção da saúde e do bem-estar. Neste artigo, exploraremos a fascinante influência dos óleos essenciais na melhoria do sono. À medida que buscamos abordar as propriedades relaxantes e terapêuticas desses óleos, examinaremos como sua aplicação pode ser uma estratégia eficaz para otimizar a qualidade do sono e proporcionar benefícios para o corpo e a mente. Objetivos; Analisar a melhora do sono, por meio dos óleos essenciais. Metodologia: A pesquisa foi realizada através do acesso online nas bases de Scientific Electronic Library Online (SCIELO), PubMed, Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS), no mês de janeiro de 2024. Foi realizada a interpretação analítica dos artigos com a temática Aromaterapia e óleos essenciais e sua relação a qualidade do sono, mediante a leitura os artigos foram submetidos a critérios de inclusão e de exclusão, dentro os de inclusão foram considerados artigos originais, que abordassem o tema e permitissem acesso integral ao conteúdo do estudo, publicados no período de 2015 a 2023, em português e em inglês. O critério de exclusão foi imposto naqueles trabalhos que não estavam nesses idiomas, e que não se relacionassem com o objetivo do estudo. Assim, totalizaram-se 31 artigos científicos para a revisão narrativa da literatura. Resultados e Discussões: Determinados óleos essenciais, lavanda e camomila, têm demonstrado potencial significativo na redução da insônia e na promoção de um sono mais profundo. A interação desses compostos com receptores no sistema nervoso central parece desempenhar um papel crucial com os seus efeitos benéficos, de forma a considerar os mecanismos subjacentes a esses efeitos. A aromaterapia, ao inalar os óleos essenciais, pode influenciar o sistema límbico, regulando a atividade cerebral associada às emoções e ao sono. Além disso, a liberação de certos compostos durante a inalação pode impactar os neurotransmissores, como a serotonina, que desempenham um papel na regulação do sono. Conclusão: Em suma, os óleos essenciais, notadamente a lavanda, demonstra promissor potencial na melhoria da qualidade do sono. Embora os resultados sejam encorajadores, é essencial continuar pesquisando para validar consistentemente esses efeitos e compreender completamente os mecanismos subjacentes. A individualidade na resposta aos óleos essenciais destaca a importância de abordagens personalizadas. Diante disso, considerando o impacto positivo observado, a inclusão cuidadosa desses recursos naturais pode oferecer uma opção complementar valiosa para aqueles que buscam aprimorar seu sono de maneira natural.
Analisa Peran Kelembagaan Petani Terhadap Adopsi Sistem Pertanian Organik
Authors: Suswadi  , Nadian Nur Aulia  , Agung Prasetyo  
Published: February 2024

The purpose of this study is to analyze the role of farmer groups in the adoption of organic farming system innovations. The location of this research was carried out in the Argoayuningtani farmer group, Selo Boyolali. The research method used is descriptive quantitative and data analysis methods use the correlation coefficient
The results of the data analysis obtained that the Learning Class Variable obtained an average Likert Scale of 4.29 (good), the Cooperation Vehicles Variable obtained an average of 4 (good), the Production Unit Variable obtained an average of 4.3 (good) and The Innovation Adoption Variable obtained an average Likert scale of 4.46 The significant value of the learning class variable is 0.000 <? 0.05. The cooperation vehicle variable is 0.197 > ? 0.05. The learning class variable is 0.000 < ? 0.05 which shows that there is a relationship between the role of farmer group production units on the adoption of organic farming system innovations. The R Square Determination Coefficient value is 0.965 or 96.5%, the effect of the role of the group on the adoption of organic farming system innovations, 3.5% is explained by other variables outside the learning class variables, collaboration vehicles and production units (good).
Analisis Kelayakan Usahatani Kopi Robusta Di Desa Jugo Kecamatan Mojo Kabupaten Kediri
Authors: Choirina Vifi Nurul , Maharani Navita , Dianasari Melinda Nur 
Published: February 2024

In the Mojo District of East Java, the Kediri Regency Government established Jugo Village as a hub for organic coffee. There is a lot of potential for coffee plants in the region. Mojo District's Jugo Village is home to one of the centers. To enable it to thereafter produce the highest-quality plants, the district administration offers help. It is anticipated that Kediri Regency will have greater coffee potential in the future. It is hoped that robusta coffee farming operations will be able to produce high income relative to the production costs paid so that the income earned by farmers is also higher, given the potential for increasing robusta coffee farming in Jugo Village. As a result, scientists studied whether growing Robusta coffee in Jugo Village, Mojo District, Kediri Regency, would be feasible. According to study findings, the R/C ratio value of robusta coffee farming in Jugo Village, Mojo District, Kediri Regency, is more than 1. This demonstrates that the farming enterprise is profitable and viable to maintain.
Keywords: Organic, Robusta Coffee, Farming Feasibility
Primavera i Narodziny Wenus Sandro Botticellego
Authors: Pieńkosz Joanna 
Published: February 2024

Tekst pochodzi z pracy magisterskiej pt. "Primavera" i "Narodziny Wenus" Sandro Botticellego. Reinterpretacje, ekfrazy, reprezentacje (promotor: prof. dr hab. Dariusz Czaja), obronionej w IEiAKUJ w roku 2016. Poświęcony jest rozwojowi badań nad obrazem, ponownym odkryciem dzieł Botticellego w kręgach prerafaelitów oraz ich późniejszej reprezentacji w kulturze.
Upaya Guru Dalam Meningkatkan Konsentrasi Belajar Siswa Pada Mata Pelajaran Pendidikan Agama Islam
Authors: Wardani Anita , Setyaningtyas Inas , Abdullah Haidar , Hambali Ilham , Septiani Estika Ayu 
Published: February 2024

Konsentrasi belajar adalah suatu hal yang harus dimiliki siswa dalam proses pembelajaran, karena konsentrasi belajar sangat mempengaruhi tercapainya tujuan pembelajaran dan juga hasil prestasi siswa. Dalam hal ini peran guru sangat diperlukan dalam rangka meningkatkan konsentrasi pembelajaran khususnya pada mata Pelajaran Pendidikan Agama Islam (PAI). Penelitian ini bertujuan untuk mengetahui upaya apa saja yang dilakukan oleh guru Pendidikan Agama Islam dalam meningkatkan konsentrasi belajar siswa pada mata Pelajaran tersebut.

Metode penelitian ini adalah deskriptif kualitatif. Subjek dalam penelitian ini adalah guru PAI serta seluruh siswa kelas VI Tahun Pelajaran 2023/2024. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Teknik analisis data yaitu dengan reduksi data, penyajian data dan penarikan kesimpulan atau verifikasi.

Hasil dari penelitian ini konsentrasi sangat penting dalam proses pembelajaran. Maka dalam hal ini peran guru sangat penting dalam meningkatkan konsentrasi belajar siswa. Upaya yang dilakukan yaitu dengan menggunakan model, strategi dan metode pembelajaran yang menarik serta memberikan pengertian dan pemahaman kepada siswa akan pentingnya Pendidikan Agama Islam. Dalam meningkatkan konsentrasi belajar siswa, guru juga mengalami beberapa macam kendala akan tetapi guru selalu bisa mengatasi atas hambatan yang ada
Kata Kunci: Konsentrasi belajar, Pendidikan Agama Islam
Peran Orang Tua Dalam Membangun Kontruksi Pengetahuan Ekonomi Pada Anak Usia Dini Di Desa Tamanan Kecamatan Gempol-Pasuruan
Authors: Rachmawati Sela , Tri Andini Yuli , Choirul Hudha  
Published: February 2024

Pengetahuan ekonomi sangat penting karena ekonomi memainkan peran sentral dalam kehidupan manusia. Ilmu ekonomi adalah the science of choice. Pengetahuan ekonomi membantu orang dalam pengambilan keputusan terbaik pada berbagai pilihan setiap hari, dalam hal mengelola keuangan pribadi, investasi dan pengeluaran. Kontruksi pengetahuan ekonomi ini sangat penting karena dapat membentuk perilaku dalam pengelolaan keuangan. Kontruksi pengetahuan ekonomi ini masih belum dilakukan secara massif. Pengetahuan ekonomi di usia dini bukan sekedar pengenalan dasar dari uang, namun membangun pemahaman lebih dari itu, yaitu awal dari pengelolaan uang yang bijak. Anak-anak dilatih mengontrol keinginan agar tidak ada pengeluaran yang tidak perlu. Sehingga anak anak bisa membedakan antara keinginan dan kebutuhan. Beberapa peneliti berpendapat bahwa pengetahuan ekonomi diberikan pada saat remaja. Karena pada usia remaja anak-anak sudah dapat berpikir secara logis dan lebih mudah memahami sesuatu. Penelitian ini menggunakan metode kualitatif dengan menggunakan teknik analisis deskriptif. Metode pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Partisipan dalam penelitian ini berjumlah 10 orang yang berdomisili di Dsn. Tamanan, Desa Kepulungan-Kecamatan Gempol-Pasuruan. Berdasarkan penelitian ini bahwa peran orangtua sangat penting dalam membangun kontruksi pengetahuan ekonomi melalui pembelajaran by experience.