bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eritema nodoso hansênico: análise comparativa do quadro histopatológico pelas técnicas de rotina e imunofluorescência
Authors: Nogueira Maria Esther S. , Fleury Raul Negrão , Arruda Maria Sueli P. 
Published: January 2024

Com a finalidade de investigara participação dos imunocomplexos (Ic) na reação de Eritema Nodoso Hansênico (ENH), fragmentos teciduais de 22 pacientes hansenianos reacionais foram avaliados através da técnica de imunofluorescência direta (IFD) em associação com técnicas histopatológicas de rotina. Os resultados demonstraram a presença de Ic em vasos e zona de membrana basal da junção dermo-epidérmica (ZMB). A presença de Ic em vasos do derma profundo e tecido celular subcutâneo em correspondência com alterações vistas sob a forma de vasculites alterativas, exsudativas e necrotizantes sugerem envolvimento destes complexos no ENH.
Prevalência de HIV1 em pacientes de hanseníase no Rio de Janeiro - Brasil
Authors: Andrade Vera , Alves Tadiana Moreira , Avelleira João Carlos Regazzi , Bayona Manuel 
Published: January 2024

A finalidade deste estudo foi a de saber se a infecção pelo HIV1 estaria associada à hanseníase no Rio de Janeiro, Brasil, comparando-se a taxa de prevalência de 1.016 pacientes de hanseníase testados de forma voluntária com 78.482 doadores de sangue. Com esta finalidade um estudo de prevalência de anticorpos anti-HIV1 foi realizado no Rio de Janeiro de 1990 a 1992. A prevalência de HIV1 em pacientes de hanseníase foi de 2,9 por 1.000 (3 casos) e entre os doadores de sangue a prevalência foi de 3,8 por 1.000 ( 282 casos ). Uma vez que os casos de HIV1 entre pacientes de hanseníase se limitaram a homens, as pacientes femininas foram excluídas das análises posteriores. Pacientes de hanseníase do sexo masculino apresentaram um prevalência ligeiramente mais alta para o HIV1 do que os doadores de sangue, antes e depois do ajuste por idade. Entretanto, este resultado não foi estatisticamente significativo (RPC ajustado = 1,38, 95% CI 0,25-4,5, p = 0,83). Estes resultados não demonstram que hanseníase e a infecção pelo HIV1 estejam associados no Estado do Rio de Janeiro. Estes achados são compatíveis com os resultados de investigações semelhantes em outros centros.
Situacion actual de la lepra en cuba: sera factible la interrupcion de la transmision?
Authors: Suárez Reinaldo E. Gil , Fernández Rolando Ramirez , Peña Manuel Santin , Lombardi Clovis 
Published: January 2024

En el presente trabajo se analizan los resultados del Programa de Control de Lepra y la situación epidemiológica actual de la endemia en Cuba, así como Ia perspectiva para pasar a etapas superiores en el control, teniendo como objetivo la interrupción de la transmisión. En el período estudiado (1988-1994) se observa que desde 1993 !a tasa de prevalencia es menor de 1 por 10,000 habitantes, aunque parece que comienza a producirse una estabilización en este indicador. En la detección de casos durante e! período 1978-1994, se presenta una ligera tendencia al descenso, lo que unido a otros indicadores hace pensar que se está produciendo una disminución de la transmisión, pero a un ritmo muy lento, por lo que de mantenerse esta tendencia todavia podría esperarse Ia ocurrencia de casos nuevos en los próximos 40 anos. En los aspectos operacionales se aprecia una aplicación de la terapia multidroga de forma regular en más del 95 % de los enfermos conocidos, aúnque el 30 % de los mismos se detectan tardiamente de acuerdo a la definición aceptada en Cuba. A pesar de las acciones de capacitación del personal y de educación a la población, inclusive en las condiciones de Cuba, con un sistema de salud con una cobertura practicamente del 100 % de la población y con fácil accesibilidad, !as características de la lepra hacen difícil llevar este indicador hasta el nivel requerido para que sea capaz de influir en la transmisión. Teniendo en cuenta todo lo anterior se concluye que, en ausencia de vacunas, para lograr la interrupción de la transmisión se requiere de la evaluación, validación e incorporación de nuevas tecnologias que permitais identificar fuentes de infección en asintomáticos o en etapas muy tempranas de la enfermedad.
Granulomatose dewegener e hanseníase: apenas uma associação fortuita?
Authors: Fleury Raul Negrão , Taborda Paulo Rogério O. , Opromolla Diltor Vladimir Araújo 
Published: January 2024

Os autores descrevem a história de um paciente portador de hanseníase virchoviana com mais de 28 anos de duração. Ele havia feito tratamento com sulfona e recebeu alta com a baciloscopia negativa. Continuou o tratamento, mas de maneira irregular, e foi reintemado 10 anos depois com lesões cutâneas ativas, e a presença de bacilos (++) em parte típicos, nos esfregaços cutâneos. Com a suspeita de sulfono-resistência fez tratamento com clofazimina (CFZ) durante 12 meses, com regressão parcial das lesões cutâneas. Apesar de reiniciar a sulfona após esse período as lesões continuaram com aspecto regressivo, a baciloscopia apenas com bacilos granulosos, e passou a apresentar episódios eventuais de reação tipo eritema nodoso hansênico. Quatro anos antes do óbito começou amanifestar sinais de insuficiência renal crônica, que foi relacionada clinicamente à amiloidose sistêmica secundária à hanseníase. A autópsia demonstrou (1) intensa impregnação de CFZ nas mucosas da vias aéreas superiores, gástrica e intestinal, e nos linfonodos, (2) infiltrados virchovianos regressivos em múltiplas localizações com bacilos granulosos e em alguns órgãos como linfonodos, fígado e baço granulomas dimoríos com baciloscopia também positiva. 3) depósito de substância amiloide emvários órgãos mas principalmente ao nível dos rins: 4) uma lesão nodular necrotizante próxima ao brônquio principal do pulmão direito, evidenciando reação granulomatosa em paliçada e vasculites granulomatosas, interpretadas como manifestação pulmonar localizada de granulomatose de Wegener (GW). Tudo levou a crer que o paciente fosse portador de uma hanseníase dimoría avançada com entorna nodoso, à qual se associou, fortuitamente ou não, a GW, seja na fase inicial ou como forma limitada, assintomática. Segundo a bibliografia consultada, a associação de duas doenças por imunocomplexos de como são a GW e a hanseníase com eritema nodoso ainda não foi previamente documentada. Admite-se que GW possa relacionar-se a alguma bactéria, ainda indeterminada, que expõe proteases neutrofílicas, gerando anticorpos neutrofílicos anticitoplasmáticos (ANCAS). Segundo os autores a hanseníase talvez pudesse neste caso, constituir a doença bacteriana subjacente. Eles comentam também que o achado destes anticorpos na hanseníase pode sugerir a procura de manifestações da GW entre outros casos desta moléstia, que pode sugerir uma real associação entre estas duas intrigantes entidades clinicas.
Role of Fashion Industry and Its Impact on Economy
Authors: Aggarwal Vibha , Bansal Sakshi , Sethi Deepti 
Published: January 2024

The purpose of this study is to ascertain whether a greater understanding of the detrimental environmental repercussions of fast fashion and its possible influence on college students' future shopping behaviour are related. In order to achieve this, we carried out a survey analysis of students' buying habits, taking into account the frequency of their clothing purchases, the popular brands they choose, and impact on environmental and their wardrobe choices. We examined results and their correlations with the fashion motto and their connectivity with clothing purchases, investigated their fast purchasing patterns, and the fashion chosen by individuals. According to our findings, a large number of people are unaware of the negative environmental effects that major brands have unless they are specifically educated about the matter.
KEYWORDS: Environment, Renewable Resources, Non-Renewable resources, Education
Pelaksanaan Ujian Jabatan Perangkat Desa Ngentep Dengan Menggunakan Sistem Ujian CAT
Authors: Aliyadi Aliyadi , Kumalasari Ellisia , Putra Wawan Trisnadi , Karaman Jamilah 
Published: January 2024

Proses rekrutmen pegawai pemerintahan telah mengalami banyak perkembangan, salah satunya dengan menggunakan CAT sebagai metode rekrutmennya. Pengabdian ini dilakukan untuk mengisi jabatan kosong dijajaran Pemerintah Desa Ngentep, yaitu Kasi Pemerintahan dan Kasi Kesejahteraan. Kegiatan ini diikuti oleh 5 peserta dan hanya 2 orang saja yang akan dinyatakan lolos. Kegiatan ini dilakukan dengan kerjasama antara Pemerintah Desa Ngentep dengan Tim Pengabdian yang terdiri dari 4 dosen Universitas Muhammadiyah Ponorogo yang berada di bawah naungan LPPM Universitas Muhamadiyah Ponorogo. Adapun hasil dari kegiatan pengabdian ini adalah 2 orang peserta yang dinyatakan lolos dan luaran hasil pengabdian seperti laporan dan jurnal pengabdian.
Availability of agricultural credit: determinants, marginal effect, and predicted probability
Authors: K K Jisha , Palakkeel Prashobhan 
Published: January 2024

Purpose. This paper aims to identify the major determinants of agricultural credit and their marginal effects, along with describing the pattern of the predicted probability of getting credit from the agricultural credit cooperatives.
Methodology / approach. We used a multi-stage stratified random sampling method to collect data from the paddy farmers of Kerala, India. Descriptive statistics are used to describe the profile of the farmers. Ordered logistic and probit regression models are used to model the credit categories. The authors analyzed the determinants of credit and their marginal effect, while the pattern of the predicted probability is described using tables and graphs.
Results. Results show that age, household size, farming experience, and farm size significantly influence the probability of a farmer falling into a particular credit category. However, the estimated coefficients of other factors, like gender and occupation, are not statistically significant. The results from the study clearly show that relatively large paddy farms are not getting enough credit from the cooperatives, contrary to the common perception. An evaluation of the predicted probabilities shows that the very high and shallow categories are much more dispersed than the middle categories.
Originality / scientific novelty. This is the first study that describes the predicted probability of credit availability pattern from the agricultural credit cooperatives to the paddy farmers. Moreover, this study describes the determinants and their marginal effects by credit category.
Practical value / implications. The results indicate the probability of a farmer falling into a specific credit category based on his/her characteristics or background. The results can help them frame a strategy while approaching a credit cooperative for a loan. The inverse relationship between age and the likelihood of getting higher credit amounts requires government policy intervention. It will be hard for farmers to continue farming while aging if they do not get sufficient credit. The government must develop policies to counteract the influence of age on credit availability, like special schemes for older age groups.
Food security, human health, and economy: a holistic approach to sustainable regulation
Authors: Mishenin Yevhen , Koblianska Inna , Yarova Inessa , Kovalova Olha , Bashlai Serhii 
Published: January 2024

Purpose. The research aims to formulate recommendations for sustainable food security regulation taking into account the agriculture intensification’s impact on public health, health-associated economic loss, and regional variations of these effects.
Methodology / approach. The impact of agricultural intensification on public health was analysed using national and regional (climate zones) data on cancer cases per 100,000 population and mineral fertiliser application per hectare of sown area from the State Statistics Service of Ukraine for 2010–2019. Regression analyses were performed using GRETL 2022c, employing OLS and ARMAX models. Additionally, health-related economic losses from contaminated food consumption in 2020 were estimated based on regional environmental damage assessments and data on environmental damage structure. These assessments informed and guided the suggestions of an organisational and economic framework essential for sustainable food security regulation.
Results. Based on global research experiences, we identified a notable positive correlation between cancer morbidity and the application of mineral fertilisers in Ukraine, both on a national scale and within four distinct natural geographical zones. These findings highlight the imperative to reconceptualise the notion of food security by incorporating the dimension of human health. Given the eco-destructive nature of the agricultural environment and the socio-ecological and economic factors influencing public health, we articulate the structural and functional elements of an organisational and economic framework essential for the sustainable regulation of food security.
Originality / scientific novelty. The research results underscore the need to redefine the concept of food security to encompass the dimension of human health. Moreover, it evaluates the economic losses related to health state resulting from consuming contaminated food across various natural and climatic zones. It demonstrates that a harmonious coexistence of food security objectives and the preservation of human health can be achieved by developing a suitable organisational and economic framework for sustainable food security regulation.
Practical value / implications. The comprehensive assessment of environmental and economic damage to public health caused by contaminated food consumption, considering regional contexts and natural geographical zones, enables determining the scale of environmental, economic and medical risks and, thus, making adequate and optimal management decisions in sustainable food security regulation based on ecologisation of agricultural production.
Conservation of rural human resources in Ukraine: modelling the relationship between migration and economic development
Authors: Mulska Olha , Vasyltsiv Taras , Mitsenko Nataliia , Ivaniuk Uliana , Lekh-Debera Aneta 
Published: January 2024

Purpose. The article aims to identify the relationship between migration (in the context of two channels – (1) human resource outflows and (2) remittance inflow) in rural areas and the economic development; justification of measures of preserving rural human resources in rural areas in Ukraine.
Methodology / approach. The methodological tools of the study are the construction of lag econometric models that allow identifying the influence of migration flows on key parameters of economic development, as well as the calculation of elasticity coefficients.
Results. It is determined that high international migration in Ukraine, especially from territories with a lower quality of life, remote from regional centers, leads to increase human resource outflow in rural areas, which accelerates the rate of their socio-economic degradation and extinction, respectively, does not contribute to balanced spatial development. The positive impact of migration on economic development has been identified, in particular, migration contributes to improving the financial well-being of households, is an instrument for accumulating investment capital and savings, developing small businesses, and enhancing financial inclusion. It is proved that to preserve the human resources of rural areas in Ukraine, it is necessary to implement a proactive policy aimed at balancing the labour market of communities, simplifying the principles of conducting and reducing the risks of small business, increasing the young re-emigration, improving investment capital, increasing the competitiveness of the educational sphere at the local level.
Originality / scientific novelty. A new scientific and methodological approach to assessing the dependence of the parameters of development of rural areas on migration processes due to two channels – human resources and remittance has been developed, complementary analysis of which makes it possible to identify the complex impact of migration on the socio-economic development of territories, optimal and critical volumes of migration according to various structural characteristics, migration gaps in the development of the economic system and social spheres of rural areas depending on the level of migration activity and the effectiveness of using the potential of remittance.
Practical value / implications. The practical significance of the research results lies in the development of tools for forecasting and planning the state policy of preserving human resources of rural areas in Ukraine, depending on migration aspirations and the purposefulness of remittance.
Менеджмент проєктів енергозбереження та інвестицій в енергоощадні заходи в навчальних закладах
Authors: Kyryliuk Yevhenii , Diadyk Tetyana , Levchenko Veronika 
Published: January 2024

Мета. Метою дослідження є узагальнення сучасних підходів до менеджменту проєктів енергозбереження та енергетичних інвестицій в енергоощадні заходи в навчальних закладах.
Результати. У статті доведено, що менеджмент проєктів енергозбереження та енергетичних інвестицій в енергоощадні заходи в навчальних закладах суттєво обтяжений дефіцитом бюджетів усіх рівнів та обережністю закордонних інвесторів. Зроблено висновок, що оскільки рахунки за електроенергію є однією з найвищих позицій у видатках на навчання, докладаються значні зусилля, щоб зменшити вартість рахунків за енергію через те, що ми називаємо підвищенням енергоефективності муніципальних будівель. Застосування концепції енергоефективності приводить до зменшення витрат муніципалітетів на оплату рахунків за електроенергію та дозволяє муніципалітетам використовувати заощаджені кошти для будівництва нових проєктів та підвищення рівня освітніх послуг для громадян в часи пікового навантаження або перебоїв/відключень від електромережі. Доведено, що є прямий зв’язок між поведінкою учасників освітнього процесу, їх вибором енергетичної поведінки та освітніми втратами. Крім того, ступінь реалізації теоретичного потенціалу зменшення енергетичного навантаження залежить від індивідуальних процесів прийняття рішень щодо підвищення енергоефективності в бюджетному секторі та може значно зменшити забруднення повітря та викиди парникових газів. Витрати на енергозбереження установи, які враховують при розрахунку вартості навчання, абітурієнти готові брати лише за умови, що установа має зобов’язання щодо повної ліквідації або принаймні всі відповідні заходи вжито в цьому напрямі. Тобто здійснюється закладом все для забезпечення надання освітніх послуг у комфортних умовах з урахуванням безпеки життєдіяльності. Проте, хоча для впровадження відповідних заходів заклади докладуть чимало зусиль щодо енергозбереження, це неможливо зробити без скасування воєнного стану та відновлення безперебійності електромережі по всій державі.
Наукова новизна. Новизна полягає в актуалізації впливу менеджменту проєктів енергозбереження та енергетичних інвестицій в енергоощадні заходи в навчальних закладах на вартості, а відповідно, і доступності навчання в Україні.
Практична цінність. Цінність проведеного дослідження полягає у стратегуванні проєктів енергозбереження та енергетичних інвестицій в енергоощадні заходи в навчальних закладах.
Designing of the quest-tour itinerary «Early 19th century. German cultural heritage in Kharkiv»
Authors: Chaika Tеtiana 
Published: January 2024

Purpose. The continuous evolutionary change in consumer preferences encourages the travel business to continuously look for innovative forms and techniques to meet consumer demand. There is a growing demand in the travel, tourism and hospitality sector for unique, personalized and sustainable travel. In this regard, the search for creative solutions to create highly competitive travel and sightseeing products that take into account current trends in consumer preferences is relevant. One possible avenue in this context is the creation of cultural heritage tourism products. The purpose of this study is to improve approaches to the design of cultural heritage quest-tour itineraries and to test the recommendations developed.
Results. Creative tourism plays an important role in developing and maintaining interest in cultural heritage. The creation of travel and sightseeing products based on a combination of the concepts of heritage tourism and creative tourism allows meeting the consumer demand for uniqueness, authenticity, personalization, creative involvement and self-development. It is this combination of modern, innovative types of travel and sightseeing that we consider most promising in terms of providing highly competitive, unique products. Quest-tour is a type of travel and sightseeing service, which can be successfully used in the creation of heritage tourism products in the context of modern trends of changing consumer preferences. Itinerary design techniques for heritage quest-tour should take into account the significance of the excursion sites in terms of presenting the atmosphere of the era in question; the degree of preservation of authentic excursion sites; and the amount of available factual material. In this study, we tested the technique of designing the quest-tour itinerary on the example of our developed quest-tour «Early 19th century. German cultural heritage in Kharkiv». According to the storyline, the quest-tour is about almost the earliest documented period of ethnic German life in Kharkiv.
Scientific novelty. The scientific novelty of the study lies in the improvement of the designing technique for quest-tours of cultural heritage on the basis of overlapping the concepts of heritage tourism and creative tourism.
Practical value. The value of the study lies in the practical validation of the improved technique of designing heritage quest-tours, as well as the possibility of using the results in the practical activities of travel firms in the design of excursion products.