bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological science and its societal mission during the SARS‐CoV‐2 pandemic: The Motivation Barometer as an evidence‐informed policy instrument in Belgium
Authors: Vansteenkiste Maarten , Waterschoot Joachim , Morbée Sofie , Van Oost Pascaline , Schmitz Mathias , Klein Olivier , Luminet Olivier , Yzerbyt Vincent , Van den Bergh Omer 
Published: December 2023

AbstractUpon the outbreak of the SARS‐CoV‐2 virus, it was clear that the pandemic would not only entail physical but also psychological challenges and threats to individuals’ sustained motivation, behavioral adherence, and mental health. To encourage the Belgian authorities to take these psychological aspects into account, the Motivation Barometer, a large‐scale and dynamic survey, was launched in March 2020. Its purpose was to monitor cognitive, affective, and behavioral aspects of citizens’ functioning across the pandemic, with special attention given to motivational and social factors. In the present review, we provide a description of the methodology of the Motivation Barometer, we synthesize the key findings emerging from the Motivation Barometer, we clarify how these findings were used in practice to the benefit of different societal stakeholders (i.e., the broader public, policymakers, intermediate‐level organizations, and media), and we highlight its potential contribution for the management of other societal challenges (e.g., climate change, well‐being). We conclude that the Motivation Barometer was a critical policy instrument during the SARS‐CoV‐2 pandemic in Belgium. It helped to bridge the gap between social scientists, policymakers, the media, and the general public, and, as such, allowed to demonstrate the incremental value of psychological sciences for society.
An Empirical Model and Feedforward Control of Laser Powder Bed Fusion
Authors: Shkoruta Aleksandr , Park Bumsoo , Mishra Sandipan 
Published: December 2023

Abstract
Reliable process control for the laser powder bed fusion process, especially at the melt pool scale, remains an open challenge. One of the reasons for this is the lack of suitable control-oriented models and associated control design strategies. To address this issue, this paper (1) identifies an empirical control-oriented model of geometry-dependent melt pool behavior and (2) experimentally demonstrates melt pool regulation with a feedforward controller for laser power based on this model. First, the study establishes that the melt pool signature increases as the scan lines decrease in length. An empirical model of this behavior is developed and validated on different geometries at varying laser power levels. Second, the model is used to design a line-to-line feedforward controller that provides an optimal laser power sequence for a given geometry. Finally, this controller is validated experimentally and is demonstrated to suppress the in-layer geometry-related melt pool signal deviations for different test geometries.
Effects of Timing and Types of Protein Supplementation on Improving Muscle Mass, Strength, and Physical Performance in Adults Undergoing Resistance Training: A Network Meta-Analysis
Authors: Zhou Huan-Huan , Liao Yuxiao , Zhou Xiaolei , Peng Zhao , Xu Shiyin , Shi Shaojun , Liu Liegang , Hao Liping , Yang Wei 
Published: December 2023

Precise protein supplementation strategies for muscle improvement are still lacking. The timing or type of protein supplementation has been debated as a window of opportunity to improve muscle mass, strength, and physical performance. We conducted a network meta-analysis of randomized controlled trials with protein supplements and resistance training. PubMed, Web of Science, Cochrane Library, and SPORTDiscus databases were searched until May 1, 2023. We included 116 eligible trials with 4,711 participants that reported on 11 timing and 14 types of protein supplementation. Compared with placebo, protein supplementation after exercise (mean difference [MD]: 0.54 kg [95% confidence intervals 0.10, 0.99] for fat-free mass, MD: 0.34 kg [95% confidence intervals 0.10, 0.58] for skeletal muscle mass) and at night (MD: 2.85 kg [0.49, 5.22] for handgrip strength, MD: 12.12 kg [3.26, 20.99] for leg press strength) was most effective in improving muscle mass and strength, respectively (moderate certainty). Milk proteins (milk, whey protein, yogurt, casein, and bovine colostrum), red meat, and mixed protein were effective for gains in both muscle mass and strength (moderate certainty). No timing or type of protein showed a significant enhancement in physical performance (timed up-to-go test, 6-min walk test, and gait speed). Pre/postexercise and Night are key recommended times of protein intake to increase muscle mass and strength, respectively. Milk proteins are the preferred types of protein supplements for improving muscle mass and strength. Future randomized controlled trials that directly compare the effects of protein timing or types are needed. This trial was registered at International Prospective Register of Systematic Reviews as CRD42022358766.
A high-quality genome of an undescribed
Flavobacterium
species uncovered using Q20+ Nanopore chemistry
Authors: Hofer Cyrill , Wälchli Denise , Moncadas Lucas Serra , Rain-Franco Angel , Andrei Adrian-Stefan 
Published: December 2023

ABSTRACT

Herein, we document the complete genome of the
Flavobacterium
strain ZE23DGlu08, isolated from Lake Zurich, Switzerland. The circular genome was assembled using long-read Nanopore data (coverage: 226×) with the Q20+ chemistry. The described strain displays a genome size of ~3.9 Mbp with a GC content of 34%.
Draft genome sequence of
Lactiplantibacillus plantarum
KCKM 0106, isolated from mustard leaf kimchi
Authors: Ko Hye In , Kim So-Rim , Jeong Chae-Rim , Lee Moeun , Eun Jong-Bang , Kim Tae-Woon 
Published: December 2023

ABSTRACT

Lactiplantibacillus plantarum
KCKM 0106, isolated from mustard leaf kimchi, demonstrates probiotic properties, such as acid tolerance and adhesion to intestinal epithelial cells. We present the draft genome sequence of
L. plantarum
KCKM 0106, comprising 3,328,662 bp and 44.4% GC content.
Draft genome sequence of
Mannheimia haemolytica
strain Oliden, isolated from a calf lung infection in Argentina
Authors: Franchi Agustín , Fazzio Luis , Fernandez Julieta , Sisti Federico 
Published: December 2023

ABSTRACT

We present the draft genome sequence of a
Mannheimia haemolytica
strain isolated from a postmortem lung lesion from a calf diagnosed with bovine respiratory disease. The genome sequence was 2,749,707-bp long with 2,909 putative protein-encoding genes.
Insight into bacterial and archaeal community structure ofSuaeda altissimaandSuaeda dendroidesrhizosphere in response to different salinity level
Authors: Wang Qiqi , He Dalun , Zhang Xinrui , Cheng Yongxiang , Sun Yanfei , Zhu Jianbo 
Published: December 2023

ABSTRACTSuaedaas a halophyte with wide adaptability of salinization level plays an important role in saline soil improvement and management. To some extent, the strong salt tolerance ofSuaedais influenced by rhizobacteria. However, the effect of differentSuaedaspecies and salinization level on the microbial community diversity still unknown. In our study, high-throughput sequencing technology was used to explore the difference in the bacterial and archaeal community diversity ofSuaeda altissimaandSuaeda dendroidesrhizosphere under high (EC, 8–16 dS/m) and severe (EC > 16 dS/m) saline soil. The result showed that complex soil environment andSuaedaspecies co-shaped bacterial and archaeal community structure, and pH was one of the most important driving factors. In addition, the increase of soil salinity significantly decreased the complexity of bacterial and archaeal co-occurrence network. We exploredHalomonasandCandidatus Nitrocosmicusas core microorganisms in theSuaedarhizosphere, which may play a key ecological role in improving salt tolerance and promoting growth ofSuaeda. Our study improves the macroscopic understanding of the interrelationships between soil environments-microbes-plants.IMPORTANCESuaedaplay an important ecological role in reclamation and improvement of agricultural saline soil due to strong salt tolerance. At present, research onSuaedasalt tolerance mainly focuses on the physiological and molecular regulation. However, the important role played by microbial communities in the high-salinity tolerance ofSuaedais poorly studied. Our findings have important implications for understanding the distribution patterns and the driving mechanisms of different Suaeda species and soil salinity levels. In addition, we explored the key microorganisms that played an important ecological role inSuaedarhizosphere. We provide a basis for biological improvement and ecological restoration of salinity-affected areas.
A novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis
Authors: Zhang Yizhuo , Li Shiyu , Chu Hongkun , Li Jing , Lu Shaohong , Zheng Bin 
Published: December 2023

ABSTRACT

Toxoplasmosis is a global health issue; however, there is a lack of safe and effective drugs and vaccines. Herein, we developed a novel mRNA vaccine, TGGT1_278620 mRNA-lipid nanoparticle (LNP), and evaluated its safety and efficacy in BALB/c mice. The vaccine elicited a significant increase not only immunoglobulin (Ig)G and IgG subclasses (IgG2a and IgG1) antibodies but also interleukin (IL)-12, interferon-gamma, IL-4, and IL-10 cytokines. We showed that specific cellular immunity and humoral immunity were activated by combining splenocyte proliferation, cytotoxic T-cell activity, and T-cell surface molecule CD8 and CD4 ratios. Dendritic cell signaling pathway members interferon regulatory factor 8, T-Box 21, and nuclear factor kappa B were analyzed at the mRNA and protein levels, and increased differentiation and maturation were observed by examining dendritic cell surface molecules (CD83, CD86, MHC-I, and MHC-II) using flow cytometry. Finally, the survival time of the vaccinated mice was significantly prolonged after
Toxoplasma gondii
RH challenge, and the adoptive transfer of splenocytes and sera from the vaccinated mice also significantly prolonged survival. These findings suggested that the TGGT1_278620 mRNA-LNP vaccine might be a promising candidate for further development in anti-toxoplasmosis therapy.

IMPORTANCE

Toxoplasma gondii
, an obligate intracellular eukaryotic parasite, can infect about one-third of the world’s population. One vaccine, Toxovax, has been developed and licensed commercially; however, it is only used in the sheep industry to reduce the losses caused by congenital toxoplasmosis. Various other vaccine approaches have been explored, including excretory secretion antigen vaccines, subunit vaccines, epitope vaccines, and DNA vaccines. However, current research has not yet developed a safe and effective vaccine for
T. gondii
. Here, we generated an mRNA vaccine candidate against
T. gondii
. We investigated the efficacy of vaccination with a novel identified candidate, TGGT1_278620, in a mouse infection model. We screened
T. gondii
-derived protective antigens at the genome-wide level, combined them with mRNA-lipid nanoparticle vaccine technology against
T. gondii
, and investigated immune-related factors and mechanisms. Our findings might contribute to developing vaccines for immunizing humans and animals against
T. gondii
.
Rare presentation of pneumothorax in a young woman with underlying congenital pulmonary airway malformation
Authors: Shafiq Muhammad , Qadeer Tariq , Tentzeris Vasileios , Kastelik Jack 
Published: December 2023

Congenital pulmonary airway malformation (CPAM) is the most common among a rare group of congenital anomalies of the lower respiratory tract. It has variable presentation depending on its subtype and the patient’s age. It may lead to respiratory distress in neonates. It can be a particularly challenging diagnosis in children born asymptomatic but present with complications later in life such as haemoptysis, recurrent chest infections, breathlessness and pneumothorax. Prenatal ultrasound, chest X-ray, CT scan and MRI are helpful in making a radiological diagnosis.A woman in her late teens presented with shortness of breath and right pleuritic chest pain. CT’s chest showed a number of bullae of varying sizes on the right, including one huge bulla compressing all three lobes. She underwent lung volume reduction surgery via video-assisted thoracoscopy, and the histology specimen confirmed the diagnosis of CPAM type 1.
Embolism from a left ventricular myxoma presenting with acute limb ischaemia
Authors: Billones Aileen Rufo , Imperial Cindy Ruth , Gutierrez-Cayetano Maribel 
Published: December 2023

Acute limb ischaemia (ALI) secondary to cardiac myxoma is uncommon. Embolic myxoma should be considered a differential diagnosis in young patients with ALI who do not have apparent cardiovascular risk factors. A multidisciplinary approach and comprehensive care can improve outcomes and optimise the collaborative treatment of ALI. Early referral to a hospital that can provide specialised treatment for ALI helps prevent significant tissue loss and surgical complications, such as amputation.A man in his 20s presented with bilateral ALI of both lower extremities, and an arterial duplex scan revealed a thrombus occluding all arterial segments of the bilateral lower extremities. An intracardiac mass adherent to the apical and anterior interventricular septum on two-dimensional echocardiography suggested a complex myxoma. The patient was diagnosed with ALI Rutherford category III, and bilateral hip disarticulation was performed. The patient was discharged with an anticoagulant.
Severe complication after microwave thermoablation of a residual limb: multifocal full thickness cutaneous necrosis and deep venous thrombosis
Authors: Schieve Bailey , Belovs Laura , Potter Benjamin , Lannan Ford Michael 
Published: December 2023

Patients with limb loss face the challenge of having an increased risk of skin disease at residual limb sites. Hyperhidrosis is a common concern for persons with amputation and excessive sweat can cause various skin pathology. Recently, microwave thermoablation (MT) was reported as an effective off-label treatment for hyperhidrosis in patients with limb loss. We present a case in which a patient following MT procedure for hyperhidrosis of a transtibial amputation developed multifocal full thickness cutaneous necrosis and deep venous thrombosis. The possible aetiologies of these complications are discussed including vascular congestion and external thermal injury.Such a case warrants the attention of individuals and providers seeking to use MT for off-label purposes, particularly for patients with limb loss, due to the large treatment surface area and potential for temporary or permanent functional loss of the amputated limb.
Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec
Authors: Huang Rong , Xiao Lin , Zhu Jane , Cheng Justin , Torrie Jill , McHugh Nancy Gros-Louis , Auger Nathalie , Luo Zhong-Cheng 
Published: December 2023

ObjectivesDiabetes in pregnancy, whether pre-gestational (chronic) or gestational (de novo hyperglycaemia), increases the risk of adverse birth outcomes. It is unclear whether gestational diabetes increases the risk of postnatal morbidity in infants. Cree First Nations in Quebec are at high risk for diabetes in pregnancy. We assessed whether pre-gestational or gestational diabetes may increase infant hospitalisation (an infant morbidity indicator) incidence, and whether this may be related to more frequent infant hospitalisations in Cree and other First Nations in Quebec.DesignPopulation-based birth cohort study through administrative health data linkage.Setting and participantsSingleton infants (≤1 year) born to mothers in Cree (n=5070), other First Nations (9910) and non-Indigenous (48 200) communities in rural Quebec.ResultsBoth diabetes in pregnancy and infant hospitalisation rates were much higher comparing Cree (23.7% and 29.0%) and other First Nations (12.4% and 34.1%) to non-Indigenous (5.9% and 15.5%) communities. Compared with non-diabetes, pre-gestational diabetes was associated with an increased risk of any infant hospitalisation to a greater extent in Cree and other First Nations (relative risk (RR) 1.56 (95% CI 1.28 to 1.91)) than non-Indigenous (RR 1.26 (1.15 to 1.39)) communities. Pre-gestational diabetes was associated with increased risks of infant hospitalisation due to diseases of multiple systems in all communities. There were no significant associations between gestational diabetes and risks of infant hospitalisation in all communities. The population attributable risk fraction of infant hospitalisations (overall) for pre-gestational diabetes was 6.2% in Cree, 1.6% in other First Nations and 0.3% in non-Indigenous communities.ConclusionsThe study is the first to demonstrate that pre-gestational diabetes increases the risk of infant hospitalisation overall and due to diseases of multiple systems, but gestational diabetes does not. High prevalence of pre-gestational diabetes may partly account for the excess infant hospitalisations in Cree and other First Nations communities in Quebec.
Cognitive task analysis of clinicians’ drug–drug interaction management during patient care and implications for alert design
Authors: Russ-Jara Alissa L , Elkhadragy Nervana , Arthur Karen J , DiIulio Julie B , Militello Laura G , Ifeachor Amanda P , Glassman Peter A , Zillich Alan J , Weiner Michael 
Published: December 2023

BackgroundDrug–drug interactions (DDIs) are common and can result in patient harm. Electronic health records warn clinicians about DDIs via alerts, but the clinical decision support they provide is inadequate. Little is known about clinicians’ real-world DDI decision-making process to inform more effective alerts.ObjectiveApply cognitive task analysis techniques to determine informational cues used by clinicians to manage DDIs and identify opportunities to improve alerts.DesignClinicians submitted incident forms involving DDIs, which were eligible for inclusion if there was potential for serious patient harm. For selected incidents, we met with the clinician for a 60 min interview. Each interview transcript was analysed to identify decision requirements and delineate clinicians’ decision-making process. We then performed an inductive, qualitative analysis across incidents.SettingInpatient and outpatient care at a major, tertiary Veterans Affairs medical centre.ParticipantsPhysicians, pharmacists and nurse practitioners.OutcomesThemes to identify informational cues that clinicians used to manage DDIs.ResultsWe conducted qualitative analyses of 20 incidents. Data informed a descriptive model of clinicians’ decision-making process, consisting of four main steps: (1) detect a potential DDI; (2) DDI problem-solving, sensemaking and planning; (3) prescribing decision and (4) resolving actions. Within steps (1) and (2), we identified 19 information cues that clinicians used to manage DDIs for patients. These cues informed their subsequent decisions in steps (3) and (4). Our findings inform DDI alert recommendations to improve clinicians’ decision-making efficiency, confidence and effectiveness.ConclusionsOur study provides three key contributions. Our study is the first to present an illustrative model of clinicians’ real-world decision making for managing DDIs. Second, our findings add to scientific knowledge by identifying 19 cognitive cues that clinicians rely on for DDI management in clinical practice. Third, our results provide essential, foundational knowledge to inform more robust DDI clinical decision support in the future.
Cohort profile: a large EHR-based cohort with linked pharmacy refill and neighbourhood social determinants of health data to assess heart failure medication adherence
Authors: Adhikari Samrachana , Mukhyopadhyay Amrita , Kolzoff Samuel , Li Xiyue , Nadel Talia , Fitchett Cassidy , Chunara Rumi , Dodson John , Kronish Ian , Blecker Saul B 
Published: December 2023

PurposeClinic-based or community-based interventions can improve adherence to guideline-directed medication therapies (GDMTs) among patients with heart failure (HF). However, opportunities for such interventions are frequently missed, as providers may be unable to recognise risk patterns for medication non-adherence. Machine learning algorithms can help in identifying patients with high likelihood of non-adherence. While a number of multilevel factors influence adherence, prior models predicting non-adherence have been limited by data availability. We have established an electronic health record (EHR)-based cohort with comprehensive data elements from multiple sources to improve on existing models. We linked EHR data with pharmacy refill data for real-time incorporation of prescription fills and with social determinants data to incorporate neighbourhood factors.ParticipantsPatients seen at a large health system in New York City (NYC), who were >18 years old with diagnosis of HF or reduced ejection fraction (<40%) since 2017, had at least one clinical encounter between 1 April 2021 and 31 October 2022 and active prescriptions for any of the four GDMTs (beta-blocker, ACEi/angiotensin receptor blocker (ARB)/angiotensin receptor neprilysin inhibitor (ARNI), mineralocorticoid receptor antagonist (MRA) and sodium-glucose cotransporter 2 inhibitor (SGLT2i)) during the study period. Patients with non-geocodable address or outside the continental USA were excluded.Findings to dateAmong 39 963 patients in the cohort, the average age was 73±14 years old, 44% were female and 48% were current/former smokers. The common comorbid conditions were hypertension (77%), cardiac arrhythmias (56%), obesity (33%) and valvular disease (33%). During the study period, 33 606 (84%) patients had an active prescription of beta blocker, 32 626 (82%) had ACEi/ARB/ARNI, 11 611 (29%) MRA and 7472 (19%) SGLT2i. Ninety-nine per cent were from urban metropolitan areas.Future plansWe will use the established cohort to develop a machine learning model to predict medication adherence, and to support ancillary studies assessing associates of adherence. For external validation, we will include data from an additional hospital system in NYC.