bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zwischen Biologie und Bürokratie: Unheimliche Bürolandschaften in Georg Kleins <em>Miakro</em> und Jeff VanderMeers <em>Authority</em>
Authors: Müller Alexandra 
Published: January 2024

Following a brief overview of various forms and functions of office settings in fantastic literature, this article will discuss the representation of the supernatural workplace in Georg Klein’s Miakro (2018) and Jeff VanderMeer’s Authority (2014). Both novels bring together seemingly disparate worlds: the natural and the bureaucratic sphere. Klein’s text is about a group of employees who work and live in an animated organic office without a traditional public-private divide, which turns out to be part of a giant mushroom. VanderMeer’s novel concerns itself with the stealthy invasion of a secret government agency by Area X, an ecosystem of extraterrestrial origin that transforms human beings into posthuman creatures. In this this paper, I analyze how Kleins novel deploys its grotesque office setting to reflect dystopian tendencies in contemporary work culture by discussing ramifications of capitalist labor practices such as alienation, worker exploitation, distorted work-life balance and social conformity. Moreover, I will argue that the parasitic office creature can be interpreted as a symbolic manifestation of hyperobject capitalism. VanderMeer, in contrast, uses the haunted house in decline trope as a metaphor for the downfall of human civilization: the bureau. The story of the destruction of the governmental agency by a pristine wilderness therefore questions an anhropocentric worldview by dissolving the dichotomy between the human and the nonhuman. I will demonstrate how the author links the collapse of the bureaucratic rule with the impending end of the human episteme. Paying particular attention to the description of spatial relations, I will furthermore examine how the texts use elements of Gothic and Weird Fiction in order to turn man-made uncanny places into monstrous nonhumanen spaces.
“I’m still not over feeling so isolated”: Métis women, Two-Spirit, and gender-diverse people’s experiences of the COVID-19 pandemic
Authors: Jones Carly , Auger Monique D. , Paul Willow , Monchalin Renée 
Published: January 2024

Abstract
Objectives
The aim of this study was to explore and learn from the experiences of Métis women, Two-Spirit, and gender-diverse people accessing health and social services in Victoria, British Columbia, during the COVID-19 pandemic.

Methods
This paper comes from a larger study exploring Métis women, Two-Spirit, and gender-diverse people’s experiences accessing health and social services in Victoria. Using a by-and-for Métis approach that employed a conversational interview method, we conducted interviews with Métis women, Two-Spirit, and gender-diverse people who lived in and/or accessed services in Victoria in December 2020 and January 2021. This paper focuses specifically on data addressing how COVID-19 impacted these participants.

Results
A total of 24 Métis women, Two-Spirit, and gender-diverse people participated in the study. Overall, three themes specific to COVID-19 were identified. First, participants described the detrimental impacts of COVID-19 on their ability to connect with their Métis community and practice their culture, as well as their overall feelings of isolation. Second, participants highlighted some of the ways that COVID-19 has exacerbated existing barriers to culturally safe healthcare. Last, participants spoke about the mixed economic impacts that COVID-19 has had for them, sharing insight into the ways in which gender, in particular, has shaped their financial instability.

Conclusion
Improving access to culturally safe health and social services by incorporating the experiences and expertise of Métis women, Two-Spirit, and gender-diverse people is crucial to mitigating the disproportional negative impacts of the pandemic and improving overall health outcomes within Métis communities across Canada.
Basic therapeutic approaches to the management of hematology/oncology patients with new coronavirus infection (COVID-19)
Authors: Misyurina E. N. , Baryakh E. A. , Frolova N. F. , Kotenko O. N. , Mutovina Z. Yu. , Andreev S. S. , Tolstykh T. N. , Yatskov K. V. , Karimova E. A. , Makeshova A. B. , Rukavitsyn O. A. , Misyurin A. V. , Polyakov Yu. Yu. , Mingalimov M. A. , Chudnova T. S. , Gagloeva D. E. , Ivanova D. D. , Koneva A. I. , Kochneva O. L. , Zotina E. N. , Grishina E. Yu. , Shimanovskaya L. T. , Yakimets V. N. , Zhelnova E. I. 
Published: January 2024

In December 2019, cases of severe respiratory infection were reported in Wuhan, China. The disease was caused by a new, previously undescribed coronavirus, structurally similar to the then known SARS-CoV virus. The World Health Organization has named the new virus SARS-CoV-2 and the disease it causes COVID-19. The problem of COVID-19 is exacerbated by the rapid spread of the SARS-CoV-2 virus and the development of life-threatening complications, the main of which is pneumonia. Due to the severity of the condition, from 5 to 10 % of patients are treated in intensive care units.SARS-CoV-2 initially attacks the respiratory system and causes symptoms such as fever, vomiting, headache, dizziness, general weakness, and diarrhea. Then these symptoms intensify in different directions, and the disease can often lead to death.Initially, only a few methods of symptomatic treatment were available and clinical trials of drugs that had previously shown their effectiveness against infection with the MERS-CoV and SARS-CoV viruses began. Temporary recommendations have appeared suggesting the use of some drugs both in monotherapy and in combination.In patients with hematologic malignancies, the immune response to the SARS-CoV-2 coronavirus is significantly reduced, which explains the high mortality rate (up to 38 %) of these patients hospitalized for SARS-CoV-2 infection. Recently, antiviral drugs and monoclonal antibodies have become available for pre- or post-exposure prophylaxis, as well as for early treatment of COVID-19. These treatments should be offered to patients at high risk of severe COVID-19 and to those who have not responded to vaccination. However, as changes in the genetic structure of the virus accumulate, some treatments may lose their clinical effectiveness against new variants.The combination of hematological malignancies and new coronavirus infection causes a more severe course of COVID-19 compared to the population and high mortality. Factors for an unfavorable prognosis for new coronavirus infection in patients with hematological malignancies include age over 60 years, a high comorbidity index, diagnoses such as acute leukemia, especially acute myeloid leukemia and myelodysplastic syndrome, disease status (relapse, progression, as well as newly diagnosed acute leukemia), severe COVID-19, agranulocytosis (myelotoxic or tumor).
Treatment features of adult patients with acute myeloid leukemia during the COVID-19 pandemic
Authors: Gagloeva D. E. , Misyurina E. N. , Tolstykh T. N. , Baryakh E. A. , Yatskov K. V. , Karimova E. A. , Makeshova A. B. , Mingalimov M. A. , Chudnova T. S. , Ivanova D. D. , Koneva A. I. , Kochneva O. L. , Zotina E. N. , Grishina E. Yu. , Shimanovskaya L. T. , Yakimets V. N. , Zhelnova E. I. 
Published: January 2024

Background. Acute myeloid leukemia (AML) is a highly aggressive oncological disease of the blood and bone marrow, requiring extremely toxic chemotherapy and massive supportive treatment to achieve stable remission. Currently, there is no work to provide medical care to these patients with a high risk of coronavirus infection. This paper presents treatment results of a large AML patient cohort during the COVID-19 pandemic.Aim. To assess the clinical features of coronavirus infection in AML patients.Materials and methods. A retrospective cohort study included patients hospitalized at City Clinical Hospital No. 52 (Moscow) between March 2020 and March 2022. Study inclusion criteria: 1) AML diagnosed within the last 3 years before the development of the COVID-19 pandemic; 2) age over 18 years; 3) laboratory confirmed SARS-CoV-2. AML status (newly diagnosed AML, relapse/refractory disease, remission), age, gender, comorbidity index, previous AML therapy and its outcomes were also assessed.Results. Among 218 patients with acute leukemia, 60 (27.5 %) patients had acute lymphoid leukemia, 158 (72.5 %) had AML. Patients with acute promyelocytic leukemia were allocated to a separate group - 20 (9 %) patients. The statistical data of the remaining 138 (63.5 %) patients with AML, their survival and mortality rates were assessed, and the main prognostic factors influencing the mortality and severity of coronavirus infection were identified. Also, our own results were compared with world statistics.Conclusion. Coronavirus infection in AML patients significantly worsens the prognosis. The main factors influencing the severity of coronavirus infection and survival and mortality rates are age, somatic status of patients due to the presence of concomitant chronic diseases, the development of deep hypoplasia of hematopoiesis, and the active AML status (disease onset or resistant course).
Chronic lymphocytic leukemia in combination with COVID-19: clinical features and unfavorable prognosis factors
Authors: Kochneva O. L. , Baryakh E. A. , Misyurina E. N. , Zhelnova E. I. , Yatskov K. V. , Chudnova T. S. , Polyakov Yu. Yu. , Makeshova A. B. , Mingalimov M. A. , Ivanova D. D. , Shimanovskaya L. T. , Zotina E. N. , Tolstykh T. N. , Grishina E. Yu. , Gagloeva D. E. , Yakimets V. N. , Koneva A. I. , Karimova E. A. 
Published: January 2024

Background. At the end of 2019, a new coronavirus infection caused by the SARS-CoV-2 virus was registered. In March 2020, the first cases of COVID-19 were detected in Moscow. Patients with chronic lymphocytic leukemia, characterized by profound immune dysfunction, have risk factors for severe viral disease.Aim. To identify risk factors for hospital mortality and severe course of COVID-19, as well as to optimize therapeutic and preventive measures.Materials and methods. The analysis included 238 patients (142 (59 %) men and 96 (41 %) women) with chronic lymphocytic leukemia and COVID-19 with a median age of 66 (37-90) years, who were hospitalized at City Clinical Hospital No. 52 (Moscow) between April 2020 and April 2023. To compare hospital mortality and severity of COVID-19, patients were divided into 2 groups depending on the hospitalization period: 2020-2021 and 2022-2023, which correlates with the prevalence of some SARS-CoV-2 variants from December 2021 and changes in Moscow epidemiological situation.Results. Overall hospital mortality rate in 2020-2021 was 25 % (n = 45). Age over 73 years was a significant unfavorable factor in men. Cardiovascular diseases increase the risk of death by 2.3 times. Patients with a Charlson Comorbidity Index of 6 or more have a 2.2 times greater risk of death. A history of 1 or more lines of immunochemotherapy increased the risk of hospital mortality by 1.5 times. Relapse/progression of the disease were factors of unfavorable prognosis for patient survival. Binet stage C also showed a significant unfavorable prognosis. When studying all cases of death (n = 51), complications such as myelotoxic agranulocytosis, secondary bacterial complications and severe interstitial pulmonary damage >75 % were identified.Conclusion. Coronavirus infection caused by SARS-CoV-2 represents an infectious threat among patients with chronic lymphocytic leukemia and may affect the regimen and tactics of antitumor therapy. The use of a full range of preventive measures, vaccination and pre-exposure prophylaxis in this cohort of patients is of great importance.
San Andreas Fault Earthquake Hazard Model Validation Using Probabilistic Analysis of Precariously Balanced Rocks and Bayesian Updating
Authors: Rood Anna H. , Stafford Peter J. , Rood Dylan H. 
Published: January 2024

Abstract
The Mojave section of the San Andreas fault is the closest section to the megacity of greater Los Angeles. A major issue for the population is that the life-threatening hazard estimate of a future rare, large earthquake on this fault section is highly uncertain and untested at timescales and ground motions beyond limited historical recordings. Of relevance to this issue is that the nearby precariously balanced rocks at Lovejoy Buttes have survived these ground motions, despite the past tens of thousands of years of San Andreas fault earthquakes. Therefore, the fragility and age of these precariously balanced rocks provide crucial ground-motion constraints over the timescales of rare, large San Andreas fault earthquakes. We rigorously validate and update an earthquake hazard model for the Mojave section of the San Andreas fault using the independent observational data of precariously balanced rock survival at Lovejoy Buttes. The joint probability of survival of all five studied precariously balanced rocks was used to validate the hazard estimates and reweight the estimates using new Bayesian updating methods to deliver an improved, precariously balanced rock-informed earthquake hazard estimate. At an annual frequency of exceedance of 1×10−4  yr−1, equivalent to a mean return period of 10,000 yr, the precariously balanced rock survival data significantly reduced the mean hazard ground-motion estimate by 65% and the 5th–95th fractile uncertainty range by 72%. The magnitude of this inconsistency provides striking evidence for the need to reevaluate both the source and ground-motion components of our earthquake hazard model for the southern San Andreas fault.
A comparative and prospective study of ventral hernia repair by laparoscopic and open technique
Authors: Kumar Abhishek , Chumber Sunil 
Published: January 2024

Background: Ventral hernia repair is becoming more common through laparoscopic techniques; however, there is a lack of comprehensive data on the associated complication rates. We undertook a prospective study to contrast the early establishments of laparoscopic and open ventral hernia surgeries in order to fill this gap. The aim of the study was to assess and contrast the efficiency and reliability of open and laparoscopic techniques for the treatment of ventral hernias.
Methods: A prospective study was carried out at All India Institute of Medical Science, New Delhi, India between 2011 and 2014 to assess the dissimilarities between open and laparoscopic approaches in ventral hernia repairs. The study included a total of 40 cases each for open/laparoscopic ventral hernia repair procedures.
Results: Eighty cases were investigated, forty of which underwent open repairs and forty of which underwent laparoscopic procedures. In this study, the oldest patient was 77 years old, and the youngest patient was 25 years old. The vast majority (49%) of patients were in their fourth to sixth decades of life. Incisional hernias were in bulk, that had formed from earlier midline lower scars. In both open and laparascopic surgery, there were 40 patients- 43 females and 37 males.
Conclusions: Ventral hernia repair via laparoscopic surgery is showing encouraging results and is currently a widely used technique. When compared to open repairs, it has benefits like decreased postoperative pain, shorter hospital stays, and fewer short-term problems. Laparoscopic hernia surgery also results in a lower risk of wound infections, an earlier restoration of bowel function, and a quicker return to regular activities.
Faktor-faktor yang Berhubungan dengan Smartphone Addiction pada Mahasiswa Profesi Ners di Masa Pandemi COVID-19
Authors: Lainsamputty Ferdy , Sanger Ailine Yoan 
Published: January 2024

Background: Smartphone users are currently growing rapidly. The majority of them are student. Lockdown may trigger the increase of smartphone addiction during pandemic.
Objective: The study aim was to determine factors related to smarthphone addiction among professional nursing students in time of COVID-19 pandemic.
Method: A descriptive correlational design with cross-sectional approach was applied with 106 students selected using consecutive sampling technique. The study questionnaire was Smartphone Addiction Scale-Short Version (SAS-SV). Statistical tests used were independent t-test, one-way Anova, and Pearson correlation.
Results: There were significant differences of smartphone addiction score based on reason to study nursing (t=-2,95; p<0,01) and purpose to use smartphone (F=2,79; p=0,03). Smartphone addiction was correlated significantly with age (r=-0,31; p<0,01) and duration of smartphone use (r=0,29; p<0,01).
Conclusion: Most of the participants were addicted to smartphone. Younger students, choosing nursing education from external direction, using longer duration of smartphone, tended to overuse this device.
Antibiotic Consumption 2017-2022 in 30 Private Hospitals in France: Impact of Antimicrobial Stewardship Tools and COVID-19 Pandemic
Authors: Roger Pierre-Marie , Lesselingue Diane , Gérard Anouk , Roghi Jacques , Quint Pauline , Un Sophie , Chincholle Agnès , Assi Assi , Bouchard Odile , Javaudin Véronique , Denes Eric 
Published: January 2024

Introduction
Our aim was to determine the impact of antimicrobial stewardship tools (AST) and COVID-19 pandemic on antibiotic consumption (AC).
Methods
We used the national software Consores to determine AC in DDD / 1000 days of hospitalization from 2017 to 2022 in voluntary private hospitals in France. The AST considered were 1/ internal guidelines 2/ list of antibiotics with restricted access 3/ presence of an antibiotic referent or 4/ an ID specialist 5/ proof of annual meeting on antimicrobial resistance. Institutions with dedicated units for COVID-19 patients were specified.
Results
In 30 institutions total AC varied from (means) 390 to 405 DDD/1000 DH from 2017 to 2022. Fluoroquinolones and amoxicillin / clavulanate consumption decreased from 50 to 36 (p = 0.003) and from 112 to 77 (p = 0.025) respectively, but consumption of piperacillin / tazobactam increased from 9 to 21 (p &lt; 0.001). Over the study period, 10 institutions with ≤ 2 AST had lower AC compared to 20 institutions with ≥ 3 AST (p &lt; 0.01). COVID-19 units opened in 10 institutions were associated with a trend toward higher macrolide consumption from 15 to 25 from 2017 to 2020 (p = 0.065) and with an acceleration of piperacillin / tazobactam consumption from 2020 to 2022 (p ≤ 0.003).
Conclusion
Antibiotic consumption in 30 private hospitals in France was inversely related to the number of AST. The COVID-19 pandemic was associated with limited impact on AC but special attention should be paid on piperacillin / tazobactam consumption.
Immune, RNA, and Neurocognitive Genetic Networks in Bipolar Disorder Subtypes: A Transcriptomic Meta-Analysis
Authors: Jang Tyler , Kaul Marcus 
Published: January 2024

Abstract
Background: Little is known about the pathogenesis of Bipolar Disorder, and even less is known about the genetic differences between its subtypes. Bipolar Disorder is classified into different subtypes, which present different symptoms and lifetime courses. While genetic studies have been conducted in Bipolar Disorder, most examined the gene expression of only Bipolar Disorder Type 1. Studies that include Bipolar Disorder Type 1 and Bipolar Disorder Type 2 often fail to differentiate them into separate conditions. Few large transcriptomic meta-analyses in Bipolar Disorder have been conducted to identify genetic pathways. Thus, using publicly available data sets we aim here to uncover significant differential gene expression that allows distinguishing Type 1 and Type 2 Bipolar Disorders, as well as find patterns in Bipolar Disorder as a whole.
Methods: We analyze 17 different gene expression data sets from different tissue in Bipolar Disorder using GEO2R and manual analysis, of which 15 contained significant differential gene expression results. We use STRING and Cytoscape to examine Gene Ontology to find significantly affected genetic pathways. We identify hub genes using cytoHubba, a plugin in Cytoscape. We find genes common to data sets of the same material or subtype.
Results: 12 out of 15 data sets are enriched for immune system and RNA related pathways. 9 out of 15 data sets are enriched for neurocognitive and metal ion related GO terms. Analysis of Bipolar Disorder Type 1 vs Bipolar Disorder Type 2 revealed most differentially expressed genes were related to immune function, especially cytokines. Terms related to synaptic signaling and neurotransmitter secretion were found in down-regulated GO terms while terms related to neuron apoptosis and death were up-regulated. We identify the gene SNCA as a potential biomarker for overall Bipolar Disorder diagnosis due to its prevalence in our data sets.
Conclusions: The immune system and RNA related pathways are significantly enriched across the Bipolar Disorder data sets. The role of these pathways is likely more critically important to the function of Bipolar Disorder than currently understood. Further studies should clearly label the subtype of Bipolar Disorder used in their research and more effort needs to be undertaken to collect samples from Cyclothymic Disorder and Bipolar Disorder Type 2.
Atmospheric Emissions Assessment for LNG Carriers: A State-of-the-Art Semi-Empirical Methodology
Authors: Gutiérrez Carlos González , Martinez Alvaro Herrero , de Navamuel Emma Diaz Ruiz , Piris Andres Ortega , Rojo Beatriz Blanco 
Published: January 2024

Abstract

This research establishes an extensive set of algorithms for the precise evaluation of fuel consumption across a range of engine types and systems onboard LNG carriers (LNGCs). The principal objective of this research is the development of a modern, universally applicable, and refined methodology tailored to LNGCs. This methodology encompasses the comprehensive calculation of both fuel consumption and atmospheric emissions, accommodating the variability in engine configurations. Furthermore, the integration of empirical data derived from 73 operational LNGCs yields a meticulously crafted operational profile. This consequential outcome of our study carries significant implications for addressing forthcoming modelling complexities specific to LNGCs.
Bayesian Network-based Mendelian Randomization for Variant Prioritization and Phenotypic Causal Inference
Authors: Sun Jianle , Zhou Jie , Gong Yuqiao , Pang Chongchen , Ma Yanran , Zhao Jian , Yu Zhangsheng , Zhang Yue 
Published: January 2024

Abstract
Mendelian randomization is a powerful method for for inferring causal relationships. However, obtaining suitable genetic instrumental variables is often challenging due to gene interaction, linkage, and pleiotropy. We propose Bayesian Network-based Mendelian Randomization (BNMR), a Bayesian causal learning and inference framework using individual-level data. BNMR employs the random graph forest, an ensemble Bayesian network structural learning process, to prioritize candidate genetic variants and select appropriate instrumental variables, and then obtains a pleiotropy-robust estimate by incorporating a shrinkage prior in the Bayesian framework. Simulations demonstrate BNMR can efficiently reduce the false positive discoveries in variant selection, and outperforms existing MR methods in terms of accuracy and statistical power in effect estimation. With application to the UK Biobank, BNMR exhibits its capacity in handling modern genomic data, and reveals the causal relationships from hematological traits to blood pressures and psychiatric disorders. Its effectiveness in handling complex genetic structures and modern genomic data highlight the potential to facilitate real-world evidence studies, making it a promising tool for advancing our understanding of causal mechanisms.