bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response
Authors: Li Dongli , Ou Qingjian , Shen Qi , Lu Michael Mingze , Xu Jing-Ying , Jin Caixia , Gao Furong , Wang Juan , Zhang Jingfa , Zhang Jieping , Li Jiao , Lu Lixia , Xu Guo-Tong , Tian Haibin 
Published: October 2023

Abstract
Background
T helper 2 (Th2) cells are thought to play critical roles in allergic conjunctivitis (AC). They release inflammatory cytokines to promote an allergic response in AC. Due to individual heterogeneity and long-term chronic management, current therapies do not always effectively control AC. Mesenchymal stem cells (MSCs) have been shown to be effective in treating allergy-related disorders, but it is unclear how exactly the Th2-mediated allergic response is attenuated. This study aims to elucidate the therapeutic effect and mechanism of the human umbilical cord MSCs (hUCMSCs) in a mouse model of experimental AC (EAC).

Methods
A mouse EAC model was established by inoculating short ragweed (SRW) pollen. After the SRW pollen challenge, the mice received a single subconjunctival or tail vein injection of 2 × 106 hUCMSCs, or subconjunctival injection of hUCMSCs conditioned medium (hUCMSC-CM), and dexamethasone eye drops was used as positive control; subsequent scratching behavior and clinical symptoms were assessed. Immunostaining and flow cytometry were carried out to show allergic reactions and the activation of CD4 + T cell subsets in the conjunctiva and cervical lymph nodes (CLNs). Gene expression was determined by RNA-seq and further verified by qRT-PCR and Western blot. Co-culture assays were performed to explore the regulatory role of hUCMSCs in the differentiation of CD4 + naive T cells (Th0) into Th2 cells.

Results
Subconjunctival administration of hUCMSCs resulted in fewer instances of scratching and lower inflammation scores in EAC mice compared to the tail vein delivery, hUCMSC-CM and control groups. Subconjunctival administration of hUCMSCs reduced the number of activated mast cells and infiltrated eosinophils in the conjunctiva, as well as decreased the number of Th2 cells in CLNs. After pretreatment with EAC mouse serum in vitro to mimic the in vivo milieu, hUCMSCs were able to inhibit the differentiation of Th0 into Th2 cells. Further evidence demonstrated that repression of Th2 cell differentiation by hUCMSCs is mediated by CRISPLD2 through downregulation of STAT6 phosphorylation. Additionally, hUMCSCs were able to promote the differentiation of Th0 cells into regulatory T cells in CLNs of EAC mice.

Conclusions
Subconjunctival injection of hUCMSCs suppressed the Th2-allergic response and alleviated clinical symptoms. This study provides not only a potential therapeutic target for the treatment of AC but also other T cell-mediated diseases.
A qualitative exploration of the psychological needs of women survivors of rape in Iran
Authors: Asadi Leila , Noroozi Mahnaz , Salimi Hajar , Mardani Fardin , Jambarsang Sara 
Published: October 2023

Abstract
Background
Rape is one of the principal forms of sexual violence leading to numerous psychological consequences for women. Providing effective psychological services to women survivors of rape requires identifying and considering their real needs. This study aimed to explore the psychological needs of women survivors of rape.

Methods
In this exploratory-descriptive qualitative study, the participants consisted of 19 women survivors of rape and 20 people with experience in providing services to survivors of rape, selected via purposive sampling method in Isfahan, Iran. In-depth individual semi-structured interviews and field notes were used to collect data, which were then analyzed using the conventional content analysis method.

Results
Based on the analysis of the interviews, the psychological needs of women survivors of rape were classified into three main categories: facing psychological problems, attention to emotional reactions, and the need to accept and adapt to reality.

Conclusions
The results revealed that women survivors of rape have different psychological needs. Thus, to meet these needs, supportive and psychological interventions can be considered at both individual and environmental levels. Also, eliminating gender stereotypes affecting the occurrence of rape in the dimensions of Iranian culture can lead to the liberation of the society from the culture of rape.
Scene clusters, causes, spatial patterns and strategies in the cultural landscape heritage of Tang Poetry Road in Eastern Zhejiang based on text mining
Authors: Li Jiayan , Xu Tao , Gu Xiaoyu , Lin Jingyuan , Li Mengyu , Tao Peiyuan , Dong Xinyue , Yao Peng , Shao Ming 
Published: October 2023

Abstract
The burgeoning field of digital humanities has provided important modern technological means for text mining in literary works. Chinese classical poetry, as a treasure in the world’s artistic treasury, holds significant value in recognizing the heritage of world culture. In this study, taking the 1589 Tang poems from the Tang Poetry Road in Eastern Zhejiang as an example, we constructed a research framework that explores the aesthetics of classical Chinese poetry landscapes and spatial imagery at the urban agglomeration scale by utilizing geographic and analytical tools such as Python programming, Gephi co-occurrence semantic networks, and GIS kernel density analysis. The framework exhibits three key innovations: (1) a text processing approach that treats individual characters as semantic units in ancient poetry texts, (2) a combined approach of Python programming techniques and Gephi visualization tool for social network analysis, and (3) a study focusing on the integration of textual and spatial aspects of literary landscape heritage corridors at the urban cluster scale. The constructed framework greatly enhances the efficiency and accuracy of Tang poetry text mining, it enables the extraction of natural and cultural landscape spatial imagery along the Tang Poetry Road, the construction of scene depictions, the identification of key regions within the scenes, and the derivation of location-specific strategies. This study broadens the scope of exploring the cultural heritage value of Tang poetry literature and provides practical guidance for the development of cross-regional heritage corridors.
Misclassification of firearm-related violent crime in criminal legal system records: challenges and opportunities
Authors: Schleimer Julia P. , Mustafa Ayah , Ross Rachel , Bowen Andrew , Gallagher Amy , Bowen Deirdre , Rowhani-Rahbar Ali 
Published: October 2023

AbstractBackgroundCriminal legal system data are one source for measuring some types of firearm-related harms, including those that do not necessarily result in injury or death, but measurement can be hampered by imprecise criminal code statutes. We quantified the degree of misclassification in Washington state criminal codes for measuring firearm-related crime.FindingsIn this study of individuals aged 18 years and older who were convicted of a misdemeanor in Washington Superior Courts from 1/1/2015 through 12/31/2019, we compared firearm-related charges as measured with criminal codes and with manual review of probable cause documents, considered the gold standard. The sample included 5,390 criminal cases. Of these, 77 (1.4%) were firearm-related as measured with criminal codes and 437 (8.1%) were firearm-related as measured via manual record review. In the sample overall, the sensitivity of criminal codes was 17.6% (95% CI 14.2–21.5%), and negative predictive value (NPV) was 93.2% (95% CI 92.5–93.9%). Sensitivity and NPV were higher for cases with exclusively non-violent charges. For all cases and for cases with any violent crime charge, firearm-related crimes described in probable cause documents most often involved explicit verbal threats, firearm possession, and pointing a firearm at or touching a firearm to someone; almost 10% of all cases involved shooting/discharging a firearm. For cases with exclusively non-violent charges, the most common firearm-related crime was unlawful possession.ConclusionsCriminal records can be used for large-scale policy-relevant studies of firearm-related harms, but this study suggests Washington state criminal codes substantially undercount firearm-related crime, especially firearm-related violent crime.
Teaching evidence-based practice to physiotherapy students in Italy: a cross sectional study
Authors: Piano Leonardo , Chiarotto Alessandro , Mascarello Marco , Turolla Andrea , Cecchetto Simone , Gianola Silvia , Castellini Greta 
Published: October 2023

Abstract
Background
Evidence-based practice (EBP) is being rapidly adopted by the Italian physiotherapy community, although a knowledge gap persists at clinical level with consequent lack of integration of EBP into ground roots practice. Teaching of EBP during the Bachelor of Science (BSc) undergraduate course in physiotherapy likely has a vital role to play in the spread of knowledge, providing a grounding in the fundamental concepts of EBP.
The aim of the present study was to investigate the prevalence of EBP educational content in Italian BSc courses in physiotherapy.

Methods
This is a cross-sectional study during which characteristics of EBP teaching in BSc degree courses of physiotherapy in Italy were collected from institutional websites during the period May to September 2021 with an update in August 2022. We used the STrengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines for our manuscript.

Results
Forty-two physiotherapy BSc degree programs were retrieved, accounting for all the BSc delivered in the 2021–2022 academic year. Fourteen of these (33.3%) did not report EBP content. Northern universities provided EBP content in 16 out of 18 (88%) degree courses. Central Italian universities provided EBP content in 6 out of 9 (66.6%) degree courses. Southern universities delivered EBP content in 3 out of 9 (33.3%) degree courses. The universities of Sicily and Sardinia provided EBP content in 2 out of 5 (40%) degree courses.
The degree courses taught in public universities were more likely to contain EBP material (25 out of 37, 67.4%), compared to those taught within the private system (3 out of 5, 60%).

Conclusions
The prevalence of EBP content within physiotherapy BSc degree programs in Italy can be considered suboptimal, with both regional differences and according to the system (public vs private). The results of this study could be used as a stimulus for increasing investment in the teaching of EBP in Italian physiotherapy degree courses, thereby improving educational standards.
Heritage of the Anatolian geography: registered varieties of ancestral wheat (siyez, gacer, and menceki)
Authors: Onur Merve , Ceylan Firuze 
Published: October 2023

AbstractTurkey is one of the major regions of wheat cultivation where wheat has economic, social, cultural, and archaeological values. The Anatolian lands are the homeland of wheat and the gene center of ancestral wheat varieties. Having survived without any genetic modification, ancestral wheat is a biological and cultural heritage. The rich nutritional value, unique flavor, and aroma of ancestral wheat varieties make them more valuable than their modern equivalents. However, prioritizing the production of modern wheat varieties has prompted the oblivion of ancestral ones and a decline in their production. This study aimed to raise awareness about the registered ancestral wheat varieties (i.e., siyez, gacer, and menceki), the cultural heritage of Anatolia, which has sunk into oblivion. To this end, it tackled the general characteristics of ancestral wheat varieties, an indispensable part of the Turkish cuisine, their nutritional value, and their use in local cuisines. Increasing the use of these registered ancestral wheat varieties in local culinary cultures and ensuring the sustainability of local values increases the significance of this study.
Development of Hyperpolarized NMR Molecular Probes for Biological Applications
Authors: Sando Shinsuke 
Published: October 2023

Abstract
Our bodies are composed of molecules. The dynamic activity of molecules is the essence of living phenomena. Toward the analysis of this, the establishment of in vivo molecular imaging techniques has been sought. Hyperpolarized nuclear magnetic resonance (NMR) is a promising technique that enables in vivo molecular imaging using highly sensitive hyperpolarized NMR molecular probes and is expected to be a next-generation molecular imaging technology. However, a major challenge lies in the rapid relaxation of the hyperpolarized nuclear spin state of the molecule, i.e., a short lifetime of high sensitivity. We have made our efforts to address this critical issue. This award account mainly describes our research to develop hyperpolarized molecular probes with long hyperpolarization lifetime. Based on the understanding of the relaxation mechanism of hyperpolarized spin states, we successfully developed various hyperpolarized 13C molecular probes, some of which were applied for in vivo studies. In addition, we demonstrated the development of hyperpolarized 15N molecular probes with remarkably long hyperpolarization lifetimes. These results pave the way for the rational design of hyperpolarized molecular probes, which has been difficult to achieve so far.
Angle-resolving spectral ellipsometry using structured light for direct measurement of ellipsometric parameters
Authors: Kim Mingyu , Lee Seungwoo , Pahk Heuijae 
Published: October 2023

We propose a compact angle-resolving spectral ellipsometry. Using the structured light
generated from a digital micro-mirror device (DMD), what we believe to
be a novel pattern is illuminated to the back focal plane of the high
numerical aperture (NA) objective lens. As a result, ellipsometric
parameters with fine resolution of both the wavelength and incidence
angle domain can be directly measured. The incidence angle can be
resolved by resolution under 1° ranging from 35° to 59° by the radius
of the projected images. A spectrometer as a detector enables
acquisition by the resolution of 0.7 nm from 410 to
700 nm, and the fiber reduces measurement spot size to a single
micrometer. Additionally, the measurement process does not require any
rotating optical components or moving parts, needing only digital
modification of the projected image. This simplifies the sequences and
reduces the measurement time. The 2D (angle of incidence and spectral
domain) ellipsometric parameter plane measured by the proposed method
was used to measure the thickness of various samples. The measurement
result was verified in comparison with a commercial ellipsometer. The
accuracy and precision of the result show that the proposed method is
capable of precise measurement of thin films.
Sustainable Land Use and Climate Change in Belgrade - The Role of Urban Gardens
Authors: Miljković Jelena Živanović , Pantić Marijana , Čepić Slavica 
Published: October 2023

Population growth and urban sprawl are expected to continue increasing pressures on agricultural land, green infrastructure and climate change's impact on the urban environment. Accordingly, the challenge of securing sustainable land use and climate change mitigation needs to be confronted in cities globe wide. Urban green areas represent an asset of public interest with multiple roles – they are recreational zones, noise and pollution protection belts, areas with aesthetic, social and curative values as well as an infrastructure for combating climate change. All these functions accentuate the relevance of urban gardens in urban development, for which their preservation and development play an irreplaceable role in cities.
This paper analyses a specific form of urban gardens in Belgrade (“baštenske kolonije” or “garden colonies”) with a focus on urban land use planning. The research methodology consists of a literature and document review and systematic analysis. The study includes legislative in Serbia and urban planning documents in Belgrade, with the goal being to identify governmental and planning attitude towards urban gardening and their recognition of ecosystem services and climate change combat. The preliminary results indicate that this form of sustainable land in Belgrade is left to the spontaneous actions of individuals with no legally defined status in the previous period
Keywords: sustainable land use, urban gardens, climate change, urban planning, Belgrade.
Promotion of Sustainable Consumption in the Energy Sector
Authors: Buzoianu Ovidiu Andrei Cristian , Constantinescu Victor George , Troaca Victor Adrian , Dima Cristina 
Published: October 2023

Sustainable development as it is currently framed aims to reduce the consumption of available resources while minimizing negative impacts on the environment. Sustainability encompasses ecological, economic and social concerns. A main purpose of this term is the maintenance and development of human well-being on a local and global scale. So that this term can be approached by the population, all its attributions must be appropriated and understood. The existence of ecological conditions is necessary to lead an economically sustainable lifestyle. A control over nature and ideas of balance between human effort and nature, fostered by sustainable desolation can benefit future generations. The relevance of such an ecological balance is assessed by comparing how consumption typically occurs in modern human societies as opposed to nature. Sustainable consumption emphasizes the term "green consumption" and reducing the carbon footprint.
Key words: consumption, development, energy, sustainability
Sustainable Development as a Wicked Problem: The Case of the Brazilian Amazon Region
Authors: Machado Marcelo , Rocha Aline , Tartarotti Natalia 
Published: October 2023

The global importance of the Amazon rainforest is abundantly evident. It is the world’s largest tropical rainforest, home to incredible biodiversity, and arguably an essential part of the earth’s already fragile climate system. Exploiting the Amazon beyond planetary boundaries, in other words, beyond a threshold the forest cannot regenerate itself from, may have catastrophic, global impacts. Conversely, Brazil is an industrialized yet developing country far from realizing its potential to become an economic superpower. To this day, millions of Brazilians still live below the poverty line. Hence, Brazil cannot afford to ignore the economic potential of the Amazon’s vast resources. The issue becomes how to use those resources effectively and efficiently for economic development. The key is perhaps a sustainable development approach. Considering the diversity of internal (i.e., Brazilian) and external (i.e., foreign) stakeholders, there is no agreement of what sustainable development would mean when it comes to the Brazilian Amazon Region (BAR). The challenge is the fact that environmental and social problems are not just complex problems. According to Brown et al (2010), they are very hard to properly define. Buchanan (1992) concluded these types of problems do not fit within any specific subject matter. In this research, we propose the sustainable development of the BAR as a wicked problem (Rittel and Webber, 1973). The main purpose of this study is to conduct an analysis of stakeholders to confirm this hypothesis. This study employs systems thinking, specifically Peter Checkland’s (1989) Soft System Methodology as the conceptual foundation of the analysis of evidence from the field. Preliminary findings are summarized, and conclusions with conceptual and practical considerations are provided. Limitations and opportunities for future studies are also included.
Keywords: sustainable development, wicked problems, Brazilian Amazon, system thinking, soft system methodology.
Implementation of an Ethical Circular Hub: Framework Proposal
Authors: Garrido Susana , Nunes Carmina S. 
Published: October 2023

There are significant regional disparities regarding circular material use rates between Western European countries and other regions in the EU. Hence, there is a severe risk that the circular transition will remain slow and unevenly distributed across EU regions. Business ethics related to circular change involves some principles and practices that guide the ethical conduct of businesses operating within the circular economy. The study aims to recommend a framework to guide regional entities to implement an Ethical Circular Hub to identify new solutions and challenges regarding stakeholder collaboration, ethical circular value chains, social equity, fair labor practices, and transparency, suggesting innovative business models. This framework proposal is based on the literature review and analysis of case studies to identify and promote the best practices in terms of Ethical Circular Hubs implementation. The outcomes of this study will help improve the regional development of policy instruments in the field of Ethical Circular Hubs, identifying ethical and circular best practices to overcome transition problems, will enable countries’ regions to integrate and benchmark successful experiences and policies from other regions into their own regional reality and contribute to a more sustainable, resilient, and inclusive society.
Keywords: ethics, circular economy, ethical circular hubs, social impact, policies
The Quality of Environmental Data Disclosure. The case of Public Companies from the European Union Countries
Authors: Janicka Małgorzata , Sajnóg Artur 
Published: October 2023

In the 21st century business entities are required to change priorities and move to a sustainable relationship between environmental, social, and economic well-being. Climate and environment are phenomena of transnational and global nature, and for this reason, actions in this area should be taken at a supranational level. Nowadays, the European Union (EU) countries have been implementing directives concerning environmental changes and taxonomy for non-financial reporting. According to their requirements, public companies must disclose high-quality data in the ESG area, including the environmental indicator (E) and its components. The purpose of the study is to discuss the current state of disclosure of environmental data by public companies listed on the regulated markets of the European Union. Special emphasis is devoted to energy consumption, water, waste production, and CO2 emissions. To test the quality of environmental indicators, we used the Refinitiv database. The research period covers 2012–2021. The research sample consists of public companies listed on the leading stock markets in 27 EU member states. The findings support the clear advantage of the quality of environmental data disclosure in the ‘old’ EU member states (which joined before 2004) as to compared to the ‘new’ EU member states.
Keywords: environmental disclosure, environmental reporting, ESG, European Union, public companies.