bluuebunny/crossref_metadata_2025_split huggingface dataset:
PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer
Authors: Ding Na , Li Meiping , Zhao Xiaokun 
Published: October 2023

AbstractStudying the molecular mechanisms and regulatory functions of genes is crucial for exploring new approaches and tactics in cancer therapy. Studies have shown that the aberrant expression of PHF5A in tumors is linked to the origin and advancement of multiple cancers. However, its role in diagnosis, prognosis, and immunological prediction has not been comprehensively investigated in a pan-cancer analysis. Using several bioinformatic tools, we conducted a systematic examination of the potential carcinogenesis of PHF5A in various tumors from multiple aspects. Our analysis indicated that PHF5A expression varied between normal and tumor tissues and was linked to clinical diagnosis and prognosis in various cancers. The results confirmed a notable variation in the levels of PHF5A promoter methylation among several types of primary tumor and normal tissues and methylation of the PHF5A promoter played a guiding role in prognosis in some cancers. According to our findings, PHF5A played a critical role in tumor immunity and it might be an excellent target for anticancer immunotherapy. To sum up, PHF5A can be used in pan-cancer diagnostics, prognostics, and immunotherapy.
Development of a mobile laboratory system in hydrogen fuel cell buses and evaluation of the performance for COVID-19 RT-PCR testing
Authors: Okude Miho , Suzuki Kenji , Naito Asami , Ebashi Akio , Kusama Tomoka , Kiyotaki Junichi , Akashi Yusaku , Kiyasu Yoshihiko , Kurihara Yoko , Notake Shigeyuki , Takanashi Masaki , Setoyama Tomokazu , Kawakami Yasushi , Suzuki Hiromichi 
Published: October 2023

AbstractWe designed and developed two new types of hydrogen fuel cell (HFC) buses (motorcoach and minibus) with a mobile laboratory system. Feasibility studies have been performed for mobile laboratory testing, particularly for the laboratory performance of COVID-19 RT-PCR (PCR). We evaluated the driving range capability, PCR sample size capacity, turnaround time (TAT), and analytical performance for the detection of SARS-CoV-2. Saliva samples were used for the current study, and the analytical performance was compared with that of the reference PCR. The estimated driving range and sample size capacity of the HFC and HFC minibus were 432 km and 2847 samples, respectively, for the HFC motorcoach and 313 km and 1949 samples for the HFC minibus. For the TAT, the median time between sample submission and completion of PCR was 86 min for the motorcoach and 76 min for the minibus, and the median time between sample submission and electronic reporting of the result to each visitor was 182 min for the motorcoach and 194 min for the minibus. A secondary analysis of 1574 HFC mobile laboratory testing samples was conducted, and all negative samples were found to be negative by reference PCR. Furthermore, all samples were confirmed to be positive by reference PCR or other molecular examinations.
Elucidating the polycyclic aromatic hydrocarbons involved in soot inception
Authors: Shao Can , Wang Qi , Zhang Wen , Bennett Anthony , Li Yang , Guo Junjun , Im Hong G. , Roberts William L. , Violi Angela , Sarathy S. Mani 
Published: October 2023

AbstractPolycyclic aromatic hydrocarbons are the main precursors to soot particles in combustion systems. A lack of direct experimental evidence has led to controversial theoretical explanations for the transition from gas-phase species to organic soot clusters. This work focuses on sampling infant soot particles from well-defined flames followed by analysis using state-of-the-art mass spectrometry. We found that PAH molecules present in soot particles are all stabilomers. Kinetic Monte Carlo simulations and thermodynamic stability calculations further identify the detected PAHs as peri-condensed and without aliphatic chains. Van der Waals forces can easily link PAHs of such size and shape to form PAH dimers and larger clusters under the specified flame conditions. Our results provide direct experimental evidence that soot inception is initiated by a physical process under typical flame conditions. This work improves our understanding of aerosol particulates, which has implications for their environmental and climate change impacts.
Reducing Vocal Fatigue With Bone Conduction Devices: Comparing Forbrain and Sidetone Amplification
Authors: Nudelman Charles , Udd Daniela , Åhlander Viveka Lyberg , Bottalico Pasquale 
Published: October 2023

Purpose:
Altered auditory feedback research aims to identify methods to strengthen speakers' awareness of their own voicing behaviors, diminish their perception of vocal fatigue, and improve their voice production. This study aims to compare the effects of two bone conduction devices that provide altered auditory feedback.

Method:

Twenty participants (19–33 years old, age:
M
[
SD
] = 25.5 [3.85] years) participated in a vocal loading task using a standard Forbrain device that provides filtered auditory feedback via bone conduction and a modified Forbrain device that provides only sidetone amplification, and a control condition with no device was also included. They rated their vocal fatigue on a visual analog scale every 2 min during the vocal loading task. Additionally, pre- and postloading voice samples were analyzed for acoustic voice parameters.

Results:
Across all participants, the use of bone conduction–altered auditory feedback devices resulted in a lower vocal fatigue when compared to the condition with no feedback. During the pre- and postvoice samples, the sound pressure level decreased significantly during feedback conditions. During feedback conditions, spectral mean and standard deviation significantly decreased, and spectral skew significantly increased.

Conclusion:
The results promote bone conduction as a possible preventative tool that may reduce self-reported vocal fatigue and compensatory voice production for healthy individuals without voice disorders.
Black hole masses for 14 gravitationally lensed quasars
Authors: Melo A. , Motta V. , Mejía-Restrepo J. , Assef R. J. , Godoy N. , Mediavilla E. , Falco E. , Kochanek C. S. , Ávila-Vera F. , Jerez R. 
Published: October 2023

Aims. We have estimated black hole masses (MBH) for 14 gravitationally lensed quasars using Balmer lines; we also provide estimates based on MgII and CIV emission lines for four and two of them, respectively. We compared these estimates to results obtained for other lensed quasars.
Methods. We used spectroscopic data from the Large Binocular Telescope (LBT), Magellan, and the Very Large Telescope (VLT) to measure the full width at half maximum of the broad emission lines. Combined with the bolometric luminosity measured from the spectral energy distribution, we estimated MBH values and provide the uncertainties, including uncertainties from microlensing and variability.
Results. We obtained MBH values using the single-epoch method from the Hα and/or Hβ broad emission lines for 14 lensed quasars, including the first-ever estimates for QJ0158−4325, HE0512−3329, and WFI2026−4536. The masses are typical of non-lensed quasars of similar luminosities, as are the implied Eddington ratios. We have thus increased the sample of lenses with MBH estimates by 60%.
G189.6+03.3: The first complete X-ray view provided by SRG/eROSITA
Authors: Camilloni Francesco , Becker Werner 
Published: October 2023

Context. G189.6+03.3 and IC443 are two examples of supernova remnants (SNRs) located in a region rich in gas and dust, and spatially close to the HII region S249. So far, the actual shape of IC443 is believed to be given by the past action of multiple supernova (SN) explosions, while a third unrelated SN might have originated G189.6+03.3.
Aims. Although the IC443 nebula has been extensively observed in several bands, on the contrary, the nearby and much weaker SNR G189.6+03.3, discovered in 1994 with ROSAT, has received very little attention. Given the relatively large extent of this second remnant, the new dataset provided by the X-ray telescope eROSITA on board the Spectrum Roentgen Gamma mission provides a unique opportunity to characterize it more in detail.
Methods. We provide a full spectral characterization of G189.6+03.3 emission for the first time, together with new images covering the whole remnant. As one of the leading hypotheses is that its emission partially overlaps with the emission from IC443, we test this scenario by dividing the remnant into several regions from which we extracted the spectra.
Results. The new X-ray images provided by eROSITA show an elongated structure. Together with the detection of supersolar abundances of O, Mg, Ne, and Si and a subsolar abundance of Fe, these features could be an indication of a faint SN explosion. The X-ray spectra also highlight the presence of a 0.7 keV plasma component across all of the regions, together with an almost uniform column density.
Conclusions. The ubiquitous presence of the 0.7 keV plasma component is a strong indication that G189.6+03.3 completely overlaps with IC443. We propose that the progenitors of G189.6+03.3 and IC443 could have been expelled from the same binary or multiple system, and this originated two explosions at different times and in different positions.
Astronomical CH3+ rovibrational assignments
Authors: Changala P. Bryan , Chen Ning L. , Le Hai L. , Gans Bérenger , Steenbakkers Kim , Salomon Thomas , Bonah Luis , Schroetter Ilane , Canin Amélie , Martin-Drumel Marie-Aline , Jacovella Ugo , Dartois Emmanuel , Boyé-Péronne Séverine , Alcaraz Christian , Asvany Oskar , Brünken Sandra , Thorwirth Sven , Schlemmer Stephan , Goicoechea Javier R. , Rouillé Gaël , Sidhu Ameek , Chown Ryan , Van De Putte Dries , Trahin Boris , Alarcón Felipe , Berné Olivier , Habart Emilie , Peeters Els 
Published: October 2023

Context. The methyl cation (CH3+) has recently been discovered in the interstellar medium through the detection of 7 μm (1400 cm−1) features toward the d203-506 protoplanetary disk by the JWST. Line-by-line spectroscopic assignments of these features, however, were unsuccessful due to complex intramolecular perturbations preventing a determination of the excitation and abundance of the species in that source.
Aims. Comprehensive rovibrational assignments guided by theoretical and experimental laboratory techniques provide insight into the excitation mechanisms and chemistry of CH3+ in d203-506.
Methods. The rovibrational structure of CH3+ was studied theoretically by a combination of coupled-cluster electronic structure theory and (quasi-)variational nuclear motion calculations. Two experimental techniques were used to confirm the rovibrational structure of CH3+:(1) infrared leak-out spectroscopy of the methyl cation, and (2) rotationally resolved photoelectron spectroscopy of the methyl radical (CH3). In (1), CH3+ ions, produced by the electron impact dissociative ionization of methane, were injected into a 22-pole ion trap where they were probed by the pulses of infrared radiation from the FELIX free electron laser. In (2), neutral CH3, produced by CH3NO2 pyrolysis in a molecular beam, was probed by pulsed-field ionization zero-kinetic-energy photoelectron spectroscopy.
Results. The quantum chemical calculations performed in this study have enabled a comprehensive spectroscopic assignment of the v2+ and v4+ bands of CH3+ detected by the JWST. The resulting spectroscopic constants and derived Einstein A coefficients fully reproduce both the infrared and photoelectron spectra and permit the rotational temperature of CH3+ (T = 660 ± 80 K) in d203-506 to be derived. A beam-averaged column density of CH3+ in this protoplanetary disk is also estimated.
Left Atrial Vent Device
Authors: Wiltfang Daniel H. , Doty Donald B. 
Published: October 2023

A right angle sump catheter device for use in venting the left side of the heart through the left atrium during operations using cardiopulmonary bypass has been described. Design features were based upon aspiration of the most dependent portion of the left atrium. It has proven useful in rendering a dry operating field.
Aspiration of blood returning to the left side of the heart during cardiopulmonary bypass from bronchial or aorto-pulmonary collateral circulation is necessary in many open intracardiac operations. Traditionally, this blood has been removed through a catheter inserted through the apex of the left ventricle. This method has generally been satisfactory, but problems associated with catheter position in trabeculae of the left ventricle, control of suction, damage to the ventricular myocardium, and risk of hemorrhage have led to use of the left atrium as the venting site of choice in most instances. A vent catheter inserted into the left atrium offers major safety and convenience factors, as well as placing the aspiration catheter at the most dependent point in the heart. A right angle sump device has been designed and used in over 500 open intracardiac procedures. It has proven to be very effective and essentially problem free in removing blood from the left atrium.
Arterial and Venous Aspirator
Authors: Peterson Stephen 
Published: October 2023

It is important to remove all the bubbles from the perfusate before going on bypass. By using the hose end to Leur Lok connector on the end of one of the suction lines, the cannula and connector can be completely freed of air bubbles.
A cannula aspirator can be connected to the end of one of the suction lines of the heart-lung bypass set-up to aspirate air from the connector and cannula. This technique is faster than using a syringe, and the blood can be saved by putting it back into the system. (See Figure 2)
Core Needle Biopsy Accuracy for Androgen Receptor Expression in Invasive Breast Cancer
Authors: Santos Marcelle Morais dos , Frasson Antonio Luiz , Silva Vinicius Duval da , Maciel Aluísio de Castro Antunes , Watte Guilherme , Werutsky Gustavo , Reinert Tomás , Fay André Poisl 
Published: October 2023

Abstract
Objective Breast cancer (BC) biomarkers, such as hormone receptors expression, are crucial to guide therapy in BC patients. Antiandrogens have been studied in BC; however, limited data are available on androgen receptor (AR) expression test methodology. We aim to report the core needle biopsy (CNB) accuracy for AR expression in BC.
Methods Patients diagnosed with stage I-III invasive BC from a single institution were included. Androgen receptor expression was evaluated by immunohistochemistry (IHC) using 1 and 10% cutoff and the AR expression in surgical specimens (SS) was the gold standard. Kappa coefficients were used to evaluate the intraprocedural agreement.
Results A total of 72 patients were included, with a mean age of 61 years old and 84% were Luminal A or B tumors. The prevalence of AR expression in all BC samples was 87.5% using a cutoff ≥ 10% in SS. With a cutoff value ≥ 1%, CNB had an accuracy of 95.8% (Kappa value = 0.645; 95% confidence interval [CI]: 0.272–1.000; p < 0.001) and 86.1% (Kappa value = 0.365; 95% CI: 0.052–0.679; p < 0.001) when ≥ 10% cutoff was used for AR positivity. Androgen receptor expression in CNB (cutoff ≥ 1%) had a sensitivity of 98.5%, specificity of 60%, positive predictive value of 97.0%, and a negative predictive value of 76.9% in the detection of AR expression in SS.
Conclusion Core needle biopsy has good accuracy in evaluating AR expression in BC. The accuracy of CNB decreases with higher cutoff values for AR positivity.
Religious diversity education: raising children’s awareness of religious diversity through augmented reality
Authors: Li Xin-Zhu , Chen Chun-Ching , Kang Xin 
Published: October 2023

AbstractReligious diversity education has become increasingly prominent in the last few years. As the region with the second-highest religious diversity globally, Chinese Taiwan provides its students religious education early on, thus minimising misunderstandings and discrimination on the basis of religion. To diversify teaching methods, educators have adopted interactive technology as one of the primary teaching aids. This study aims to develop and evaluate the impact of an interactive technology, augmented reality (AR) in the provision of religious education. A series of experiments were conducted during the 2020 Taipei Lantern Festival of Religious Education Exhibition to explore whether using the interactive technology system significantly improved learning outcomes in comparison to traditional learning methods. To this end, a total of 50 elementary students across two experimental (n = 24) and control (n = 26) groups were recruited to participate in the study. A mixed-methods approach was used to analyse students’ subjective and objective learning outcomes. The results of the study showed that the experimental group performed significantly better in both subjective and objective learning outcomes. The findings obtained from the open-ended questions showed interactive AR technology system use positively affected the learning process. In conclusion, this study proposes that combining religious diversity education with interactive AR technology has the potential to improve students’ motivation, engage their interest, improve learning outcomes, and contribute to an increased awareness of religious diversity. It may also be helpful in limiting students’ cognitive overload during the learning process.
Shielded ionisation discharge (SID) probe for spatiotemporal profiling of pulsed molecular beam
Authors: Patel Milaan , Thomas Jinto , Chandra Joshi Hem 
Published: October 2023

Intense pulsed supersonic molecular beams are used in many applications such as tokamak fueling, edge plasma diagnostics, ion beam profile monitors, laser cluster experiments, chemical kinetics, etc. Measurement of absolute density is required to optimize beam sources used in these experiments. Absolute density measurement of a continuous molecular beam is challenging due to its small size and rarefied flow, which makes it even more difficult for a pulsed molecular beam due to its transient nature. In this work, we demonstrate a novel probe to measure the spatiotemporal evolution of the absolute number density of a pulsed supersonic molecular beam. The probe is named the Shielded Ionization Discharge probe. It measures density using localized discharge within the molecular beam created by the thermionic emission of electrons from a hot filament. We describe the design, calibration, and characterization of the developed probe. The performance of the probe is demonstrated by measuring the spatial and temporal profiles of a pulsed supersonic molecular beam of 1.5 ms duration.
A liquid metal dropper for experiments on the wettability of liquid metals on plasma facing components
Authors: López Pérez C. , Marchhart T. , Kawashimo K. , Nieto-Perez M. , Parsons M. S. , Schamis H. , Allain J. P. 
Published: October 2023

A liquid metal dropper has been developed as a part of the Ion-Gas-Neutral Interactions with Surfaces 2 (IGNIS-2) facility at The Pennsylvania State University. The dropper has the capability of directly applying drops to candidate plasma facing materials for nuclear fusion reactors to enable measurements of their liquid metal wetting properties. The results presented here are specific to the use of lithium in the dropper. This paper discusses the design choices of the liquid metal dropper and its chamber, including the heating and temperature control and the dropper’s motorized operation. Lithium drops of masses ranging from 0.05 g up to 0.13 g, equivalent to drop diameters between 5.6 mm to 1 cm, have been consistently dispensed by the dropper. A new algorithm is developed and used to automate the analysis of the contact angle between the liquid drops and substrate material for efficient analysis of video data recorded to study the wetting properties of candidate plasma-facing components.
Monocular vision-based online kinematic calibration method for five-axis motion platform
Authors: Tang Xianxing , Zhou Haibo , Jiang Xuening 
Published: October 2023

Abstract
This article proposes an online kinematic calibration method for simultaneous five-axis motion for solving the problems of low kinematics accuracy and a highly complex kinematic calibration of the five-axis motion platform. First, the ArUco markers are used in a vision system for large stroke detection, while kinematics models of the five-axis motion platform are established based on the screw theory. This article proposes an online kinematic parameter identification method for simultaneous motion along five axes, using a monocular camera as a measurement tool. Furthermore, the stability and effectiveness of the identification algorithm are verified by simulation and experiment. Specifically, a process trajectory commonly used to conduct experiments verifies the scheme’s influence on the kinematic accuracy. Experimental results show that the proposed kinematic calibration method reduces the average position error of the five-axis motion platform by 88.59% and the average direction error by 84.54%, thus proving that the proposed kinematic calibration method can significantly improve the kinematic accuracy of the five-axis motion platform and verifying the applicability and effectiveness of the proposed scheme.
A multi-model method for tool wear prediction with deep temporal features and correlation alignment
Authors: Dong Jingchuan , Chen Tao , Gao Yubo , Su Depeng , Jiang Hongyu 
Published: October 2023

Abstract
Accurate prediction of tool wear is essential to ensure the machining quality of parts. However, in the actual milling process, the data distribution varies greatly between sensor signals due to variations in individual tools and machining parameters; moreover, a single deep learning model is less reliable when processing a large volume of signals. All these problems make accurate tool wear prediction challenging. Therefore, we propose a multi-model method with two-stage. In the first stage, the tool wear data is initially divided into two parts. For each part, we design a correlation-aligned multiscale convolutional temporal attention gated recurrent neural network model to perform preliminary prediction, aiming at extracting the deep temporal features from diverse signals and mitigating the sensitivity of the features to the changes in data distributions. In the second stage, we adaptively aggregate the preliminary prediction from multiple models to obtain the final prediction via a joint decision-making module to extend the decision boundary of single model and improve the tool wear prediction performance. Finally, two sets of experiments are conducted for different tools and machining conditions. The experimental results show that our proposed method significantly reduces the root mean square error (RMSE) by 15% and the mean absolute error by 18% compared to other methods.
The role of recombination in constriction of a positive column of a glow discharge in inert gases
Authors: Siasko A V , Karasev V Yu , Golubovskii Yu B 
Published: October 2023

Abstract
The work is aimed at the experimental determination of the role of volume recombination in a positive column of a DC discharge in helium during the transition from a diffuse homogeneous state to a constricted stratified regime under real discharge conditions of high electron and gas temperatures (

T
e

≈
2

eV,

T
g

>
1000

K). The investigation is based on the probe measurements of the wall current determined by the flux of charged particles towards the boundary of a cylindrical discharge tube. The experiments were carried out in helium, neon, and argon in the range of reduced pressures 1.2–300 Torr·cm. In heavy inert gases, the transition to a constricted regime is determined by the active loss of charged particles in the volume. In contrast to neon and argon, experiments in helium demonstrated that the role of volume recombination is insignificant during the transition to a constricted regime. The rate of volume losses in helium in real conditions is very low compared to neon and argon. The obtained results allow one to calculate the volume recombination rate by comparing the experimentally measured wall currents with the corresponding numerical calculations within the collision-radiative model.