bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zur Reaktion H + H + H2O → H2 + H2O
Authors: Eberius H. , Hoyermann K. , Wagner H. Gg. 
Published: October 2023

AbstractDie Rekombinationsreaktion von Wasserstoffatomen in Gegenwart von Wasser

Wurde in einem Strömungssystem mit einem ESR‐ und einem Massenspektrometer untersucht. Für die Geschwindigkeitskonstante dieser Reaktion bei T = 303 °K ergab sich der Wert von
Die Abhängigkeit des zweiten Virialkoeffizienten und der Transportphänomene in Gasen von den Exponenten des Lennard‐Jones‐Potentials
Authors: Schramm Bernbard 
Published: October 2023

AbstractDie zur Berechnung der Transportgrößen in Gasen und Gasmischungen notwendigen Stoßintegrale für mehrere Lennard‐Jones‐n‐ 7‐Potentiale wurden berechnet und in Abhängigkeit von der reduzierten Temperatur T*=kT.ϵ tabelliert. Zusammen mit den schon früher veröffentlichten Tabellen für die Stoßintegrale einiger n‐6‐Potentiale [8] ist damit die Möglichkeit gegeben, den Einfluß einer Änderung der Exponenten n und m der Lennard‐Jones‐n‐m‐Potentiale auf die Transportgrößen systematisch zu untersuchen. Eine solche Untersuchung wird hier vorgelegt. Sie schließt den zweiten Virialkoeffizienten in die Überlegungen mit ein. Durch die Einfühmng geeigneter reduzierter Größen gelingt es, die Unterschiede der einzelnen n‐m‐Potentiale zu erfassen, ohne auf Meßdaten zurückzugreifen.
über die 1H‐NMR‐Spektren linearer Di‐Aza‐Acene und ihrer N‐Oxyde
Authors: Limbach Hans‐Heinrich , Seiffert Wolfgang , Ohmes Ernst , Zimmermann Herbert 
Published: October 2023

AbstractDie 1H‐NMR‐Spektren von Chinoxalin I, Chinoxalin‐N‐monooxyd II, Chinoxalin‐N,N‐dioxyd III, Phenazin IV, Phenazin‐N‐monooxyd V, Phenazin‐N,N‐dioxyd VI, Benzo[g]chinoxalin VII, Benzo[b]phenazin VIII, Benzo[b]phenazin‐N‐monooxyd IX, Benzo[b]phenazin‐N,N‐dioxyd X, Dibenz[b,i]phenazin XI wurden gemessen. Die chemischen Verschiebungen und Kopplungskonstanten wurden auf iterativem Weg durch Angleich von experimentellen und berechneten Spektren bestimmt. Einige Konzentrations‐ und Lösungsmittelabhängigkeiten der chemischen Verschiebungen werden diskutiert.
Die Schwingungsspektren des flüssigen Fluors
Authors: Jacob E. , Goubeau J. 
Published: October 2023

AbstractIR‐ und Ramanspektren des flüssigen Fluors wurden im Bereich innermolekularer Schwingungen gemessen. Um die sehr schwache IR‐Absorption unbeeinflußt von polaren, stark absorbierenden Verunreinigungen registrieren zu können, mußte besonderes Augenmerk auf Reinigung und Manipulation des F2 gelegt werden. Es wird eine IR‐Tieftemperaturküvette für flüssiges Fluor beschrieben.
Kinetik der Manganat/Permanganat‐Redoxelektrode an Platin und Gold
Authors: Plieth W. J. 
Published: October 2023

AbstractIm Redoxsystem Manganat/Permanganat in In NaOH wurden an Platin‐ und Goldelektroden potentiostatische Einschaltmessungen durchgeführt. Aus den Strom‐Zeitkurven können durch Extrapolation auf t = 0 Anfangsstromdichten bestimmt werden. Die Anfangsstromdichte‐Potentialkurven ergeben bei kleinen Überspannungen den Durchtrittswiderstand und die Austauschstromdichte i0. Bei größeren Überspannungen besteht zwischen dem Logarithmus der Anfangsstromdichte und dem Potential eine lineare Tafel‐Beziehung. Die Tafel‐Geraden zeigen charakteristische Besonderheiten. Die Durchtrittsfaktoren α+ und α− ergänzen sich nicht zu eins. Die elektrochemischen Reaktionsordnungen sind nicht ganzzahlig, zum Teil ergeben sich negative Werte. Die Schnittpunkte der anodischen und kathodischen Tafel‐Geraden mil der Ordinate bei ϵ = ϵ0 ergeben Austauschstromdichten i0,+i0,‐ ≠ i0. Das beobachtete Verhalten kann quantitativ beschrieben werden mit einem Durchtrittsmechanismus aus zwei konsekutiven Teilreaktionen. Die Teilreaktionen sind die Adsorptions/Desorptionsreaktionen der Redoxkomponenten.
Economic simulation of batch and continuous aqueous two‐phase purification for viral products
Authors: Nold Natalie M. , Pearson Eric , Heldt Caryn L. 
Published: October 2023

AbstractVaccine manufacturing strategies that lower capital and production costs could improve vaccine access by reducing the cost per dose and encouraging localized manufacturing. Continuous processing is increasingly utilized to drive lower costs in biological manufacturing by requiring fewer capital and operating resources. Aqueous two‐phase systems (ATPS) are a liquid–liquid extraction technique that enables continuous processing for viral vectors. To date, no economic comparison between viral vector purifications using traditional methods and ATPS has been published. In this work, economic simulations of traditional chromatography‐based virus purification were compared to ATPS‐based virus purification for the same product output in both batch and continuous modes. First, the modeling strategy was validated by re‐creating a viral subunit manufacturing economic simulation. Then, ATPS capital and operating costs were compared to that of a traditional chromatography purification at multiple scales. At all scales, ATPS purification required less than 10% of the capital expenditure compared to chromatography‐based purification. At an 11 kg per year production scale, the ATPS production costs were 50% less than purification with chromatography. Other chromatography configurations were explored, and may provide a production cost benefit to ATPS, but the purity and recovery were not experimentally verified. Batch and continuous ATPS were similar in capital and production costs. However, manual price adjustments suggest that continuous ATPS plant‐building costs could be less than half that of batch ATPS at the 11 kg per year production scale. These simulations show the significant reduction in manufacturing costs that ATPS‐based purification could deliver to the vaccine industry.
The Challenge and Obstacles of Becoming an iSchool: The Case of Zadar, Croatia
Authors: Aparac‐Jelušić Tatjana 
Published: October 2023

EDITOR'S SUMMARYThe journey of the University of Zadar's Department of Information Sciences to iSchool recognition reflects the challenging requirements for an academic institution to attain that status. The department was accredited in 2014, with undergraduate and graduate programs evolving from the Department of Librarianship, accredited since 2005. The department co‐publishes a scientific journal, organizes professional conferences, operates a joint graduate program with other universities, promotes active involvement in international professional organizations and encourages collaboration with universities around the world to promote student exchange studies. Admission requirements, curricula and professional competencies follow recommendations for all levels of study, with special focus at the doctoral level on supporting Croatia's written heritage. Having demonstrated institutional dedication to the field of information sciences and support of robust academic study, the department's sole remaining obstacle for full recognition as an iSchool is stable research funding.
The tumor suppressive effect and apoptotic mechanism of TRAIL gene‐containing recombinant NDV in TRAIL‐resistant colorectal cancer HT‐29 cells and TRAIL‐nonresistant HCT116 cells, with each cell bearing a mouse model
Authors: Jung Bo‐Kyoung , An Yong Hee , Jang Sung Hoon , Ryu Gyoungah , Jung Saet‐byel , Kim Seonhee , Kim Cuk‐Seong , Jang Hyun 
Published: October 2023

AbstractBackgroundTRAIL is an anticancer drug that induces cancer cell apoptosis by interacting with death receptors (DRs). However, owing to low cell‐surface expression of DRs, certain colorectal cancer (CRC) cells resist TRAIL‐induced apoptosis. Newcastle disease virus (NDV) infection can elevate DR protein expression in cancer cells, potentially influencing their TRAIL sensitivity. However, the precise mechanism by which NDV infection modulates DR expression and impacts TRAIL sensitivity in cancer cells remains unknown.MethodsHerein, we developed nonpathogenic NDV VG/GA strain‐based recombinant NDV (rNDV) and TRAIL gene‐containing rNDV (rNDV‐TRAIL). We observed that viral infections lead to increased DR and TRAIL expressions and activate signaling proteins involved in intrinsic and extrinsic apoptosis pathways. Experiments were conducted in vitro using TRAIL‐resistant CRC cells (HT‐29) and nonresistant CRC cells (HCT116) and in vivo using relevant mouse models.ResultsrNDV‐TRAIL was found to exhibit better apoptotic efficacy than rNDV in CRC cells. Notably, rNDV‐TRAIL had the stronger cancer cell‐killing effect in TRAIL‐resistant CRC cells. Western blot analyses showed that both rNDV and rNDV‐TRAIL infections activate signaling proteins involved in the intrinsic and extrinsic apoptotic pathways. Notably, rNDV‐TRAIL promotes concurrent intrinsic and extrinsic signal transduction in both HCT‐116 and HT‐29 cells.ConclusionsTherefore, rNDV‐TRAIL infection effectively enhances DR expression in DR‐depressed HT‐29 cells. Moreover, the TRAIL protein expressed by rNDV‐TRAIL effectively interacts with DR, leading to enhanced apoptosis in TRAIL‐resistant HT‐29 cells. Therefore, rNDV‐TRAIL has potential as a promising therapeutic approach for treating TRAIL‐resistant cancers.
Colitis cystica profunda: A report of two cases
Authors: Jiang Qingling , Qin Si , Zhang Han , Liu Guangjian 
Published: October 2023

Key Clinical MessageColitis cystica profunda (CCP) is a rare benign disease characterized by mucus‐filled cysts in the submucosa. Endoscopic, radiological and histological examinations are not highly specific, which can lead to misdiagnosis, resulting in unnecessary radical surgical resection. This report presents two cases of CCP with their clinical and imaging features.
Rheumatic mitral valve disease with left atrial myxoma: Unexpected encounter
Authors: Yang Jiaqi , Huang Kun , Li Xuejie 
Published: October 2023

Key Clinical MessageRheumatic mitral stenosis associated with left atrial myxoma has been reported previously. We reported an admitted rare case of rheumatic mitral regurgitation with left atrial myxoma. The discrimination between left atrial myxoma and thrombi presents a diagnostic challenge in the presence of rheumatic mitral valve disease.
Facial pyoderma gangrenosum associated with fallopian tube carcinosarcoma
Authors: Mardani Ghazal , Shahidi Dadras Mohammad , Abdollahimajd Fahimeh , Safari Giv Toktam , Pourgholi Elnaz , Rakhshan Azadeh , Ghalamkarpour Fariba 
Published: October 2023

Key Clinical MessagePyoderma gangrenosum (PG) is a neutrophilic dermatosis associated with underlying disorders. The association between PG and solid organ tumors (SM), including gynecologic cancers, has been previously reported. Here, we report a case of a 61‐year‐old woman with pyoderma gangrenosum on the posterior auricular region associated with an underlying fallopian tube carcinosarcoma: a rare and aggressive gynecologic malignancy. The patient's ulcer responded favorably to treatment, and surgical resection of the tumor was performed. The patient was then referred for further cancer management. No new lesions or recurrences were found over the 18 months of routine follow‐up.
Fine‐needle aspiration biopsy of axillary lymph nodes: A reliable diagnostic tool for breast cancer staging
Authors: Sallout Luai , Tashkandi Mohamed , Moqnas Amani , AlMajed Hebah , Al‐Naeem Abdulrhman , Alwelaie Yazeed 
Published: October 2023

AbstractBackgroundPathologic evaluation of sentinel lymph node biopsy (SLNB) samples is crucial for axillary staging in patients newly diagnosed with breast cancer. Patients with pathologic evidence of nodal metastasis scheduled for upfront surgery typically also undergo axillary lymph node dissection (ALND). Although SLNB is the gold standard method for detecting nodal metastasis, axillary lymph node fine‐needle aspiration biopsy (FNAB) utility has not been thoroughly explored.MethodsUltrasound‐guided axillary lymph node FNAB samples along with concurrent ipsilateral breast tissue samples were searched and reviewed. The control group included histologic findings of axillary dissection or intraoperative SLNB results.ResultsA total of 354 axillary lymph node FNAB samples with matched histology were included. Of these, 187 (52.8%) were positive for metastatic carcinoma of breast origin; 143 (40.4%) were negative for metastasis; 12 (3.4%) showed atypical cells; six (1.7%) were suspicious for metastasis; and six (1.7%) were nondiagnostic because of a lack of lymphoid tissue and malignant cells. Of the 143 negative FNAB samples, 22 (15.4%) were positive on either intraoperative SLNB or ALND. When only the positive and negative FNAB samples were accounted for (n = 330; 93.2%), overall diagnostic sensitivity and specificity were 89.4% and 99.2%, respectively.ConclusionsAlthough axillary SLNB is the standard procedure for detecting nodal metastasis of breast origin, axillary lymph node FNAB appears to be a suitable alternative in a significant proportion of patients. A standard SLNB should be performed in cases of negative axillary lymph node FNAB findings, particularly nodes with abnormal imaging findings.
Wnt1 induces osteoblastic changes in a well‐established osteolytic skeletal metastatic model derived from breast cancer
Authors: Sugyo Aya , Tsuji Atsushi B. , Sudo Hitomi , Sugiura Yoshiya , Koizumi Mitsuru , Higashi Tatsuya 
Published: October 2023

AbstractBackgroundOsteoblastic skeletal metastasis is frequently observed in prostate cancer. An effective therapy has not been developed due to the unclear molecular mechanism. The Wnt family is involved in various biological phenomena including bone metabolism. There is no direct evidence that the family causes osteoblastic skeletal metastasis.AimsThe present study aims to evaluate whether overexpressed Wnt induces osteoblastic bone metastasis in a well‐established osteolytic bone metastatic model.Methods and ResultsThe breast cancer‐derived 5a‐D‐Luc‐ZsGreen cells were transfected with Wnt1, Wnt3A, and Wnt5A expression vectors, producing stably highly expressing cells. These cells were intracardially transplanted in nude mice. Bone metastasis development was confirmed by fluorescence imaging. Hind‐limb bones including metastasis were dissected and visualized through micro‐CT imaging. After imaging, sections were stained with hematoxylin and eosin (H&E), and immunohistochemically stained with an anti‐SATB2 antibody. Luminescent imaging confirmed mice with bone metastases in the hind limbs. Micro‐CT imaging found an osteoblastic change only in bone metastasis of mice transplanted with Wnt1‐expressing cells. This was confirmed on H&E‐stained sections. SATB2 immunostaining showed differentiated osteoblasts were at the site of bone metastases in the diaphysis. SATB2 in the Wnt/β‐catenin pathway activated by overexpressed Wnt1 could induce osteoblastic change.ConclusionOur findings provided direct evidence Wnt1 is involved in osteoblastic bone metastasis development. Our model would be a powerful tool for further elucidating molecular mechanisms underlying the disease and developing effective therapies.
Fuzzy based multi‐criteria based cluster head selection for enhancing network lifetime and efficient energy consumption
Authors: Srivastava Ankita , Mishra Pramod Kumar 
Published: October 2023

SummarySensors plays an important role in day‐to‐day life as they sense and transfer data on the cloud and servers. These sensors have limited battery power due to which their optimized use is preferred with efficient energy consumption. As sensors were deployed almost everywhere under‐earth, underwater, electronic devices, and mobiles thus their enhanced performance is really important. In WSN, clustering is considered to be an essential approach that gives various advantages such as efficient energy, stability period, network lifetime, less delay, and scalability but has an issue of hot‐spot or energy‐hole problems. For this Un‐Equal Clustering is proposed where the size of clusters varies directly to the distance of the B.S. (Base Station). The main objective of Un‐Equal clustering is energy consumption, hot‐spot problem, and load balance among the cluster heads. In this paper, we have proposed an improved fuzzy‐based multi‐attributes un‐equal clustering to overcome the problem of hot‐spot problem. Earlier, researchers considered two attributes for selecting cluster heads (CHs), but later some of the MADM approaches were used that considered multiple attributes for optimal cluster head selection. In this paper, we have applied the fuzzy‐based TOPSIS method for optimized Un‐Equal clustering where the optimal node deployments with load balance among sensor nodes having optimal coverage and connectivity is considered. The results of the proposed method validate that it is one of the effective ways for selecting optimal cluster heads using fuzzy‐based multi‐attributes. Fuzzy‐based TOPSIS for cluster heads selection method shows 37% enhanced network performance with other compared existing algorithms. The performance of the proposed method is evaluated in terms of network stability, packet delivery, energy consumption, and network lifetime and F‐MAUC (Fuzzy based multi‐attributes un‐equal clustering) outperforms all other compared algorithms.
Investigating the effect of obsessive‐compulsive disorder on clinical symptoms of temporomandibular joint disorders
Authors: Sadrzadeh‐Afshar Maryam‐Sadat , Salari Behzad , shobeiri Ali , HafeziMotlagh Kimia 
Published: October 2023

AbstractObjectivesTemporomandibular disorders (TMD) are a group of clinical conditions involving muscles of mastication, temporomandibular joint (TMJ), and related structures or both. TMD is characterized by facial pain in TMJ and muscles of mastication, limitation or deviation of jaw movement, and TMJ sounds during jaw movement and function. The highest risk of TMD prevalence is between 18 and 24 years, and a relationship is between chronic TMD and psychological disorders such as stress and depression.The knowledge of the function of this joint and those with TMD symptoms when visiting the dentist will help to provide an ideal treatment plan for the patient. Therefore, if the therapist is familiar with the various etiological factors of this disorder, he will provide better treatment, especially if the simultaneous effect of psychological factors such as stress and obsessive‐compulsive disorder (OCD) along with occlusal factors such as posterior cross‐bite, overjet, and overbite is measured, it can be a valuable guide for clinicians.Methods and MaterialsIn this study, 385 patients were examined by DASS42 and Maudsley's test and classified into normal, with stress, and stress plus OCD groups. TMJ was examined for each of them by the TMD‐RDC test. The presence or absence of TMD was noted in their file.ResultsThe prevalence of TMD was 20.7% in the normal group, 30.70% in the stress group, and 44.68% in the stress and OCD group. After analyzing the data by SPSS 24 and performing analysis of variance and Duncan tests, no significant difference was found between the probability of TMD in normal and stressed groups, but the stress and OCD group has a higher chance of TMD.ConclusionAlthough the co‐occurrence of stress and OCD is associated with the prevalence of TMD, it cannot be considered a cause of TMD.
Virtues of Cold Isostatic Pressing for Preparation of All‐Solid‐State‐Batteries with Poly(Ethylene Oxide)
Authors: Campéon Benoît D. L. , Rajendra Hongahally B. , Yabuuchi Naoaki 
Published: October 2023

AbstractAll‐solid‐state‐batteries (ASSBs) necessitate the preparation of a solid electrolyte and an electrode couple with individually dense and compact structures with superior interfacial contact to minimize overall cell resistance. A conventional preparation method of solid polymer electrolyte (SPE) with polyethylene‐oxide (PEO) generally consists in employing uni‐axial hot press (HP) to densify SPE. However, while uni‐axial press with moderate pressure effectively densifies PEO with Li salts, excessive pressure also unavoidably results in perpendicular elongation and deformation for polymer matrix. In this research, to overcome this limitation for the uni‐axial press technique, a cold isostatic press (CIP) is applied to the fabrication of ASSB with PEO and LiFePO4. CIP effectively and uniformly applies pressure as high as 500 MPa without deformation. Characterizations confirm that CIP treated SPE has enhanced mechanical puncture strength, increasing from 499.3±22.6 to 539.3±22.6 g, and ionic conductivity, increasing from 1.04×10−4 to 1.91×10−4 S cm−1 at 50 °C. ASSB treated by CIP demonstrates remarkably enhanced rate capability and cyclability compared with the cell processed by HP, which is further evidenced by improvement of the apparent Li ion diffusion constant based on Sand equation analysis. The improvement enabled by CIP treatment originates from the superior interface uniformity between electrodes and SPE and from the densification of the LiFePO4 and SPE composite electrode.
Genomic analysis of the rhesus macaque (Macaca mulatta) and the cynomolgus macaque (Macaca fascicularis) uncover polygenic signatures of reinforcement speciation
Authors: Bailey Nick , Ruiz Cody , Tosi Anthony , Stevison Laurie 
Published: October 2023

AbstractSpeciation can involve phases of divergent adaptation in allopatry and ecological/reproductive character displacement in sympatry or parapatry. Reproductive character displacement can result as a means of preventing hybridization, a process known as reinforcement speciation. In this study, we use whole‐genome sequencing (WGS) of two closely related primate species that have experienced introgression in their history, the rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaques, to identify genes exhibiting reproductive character displacement and other patterns consistent with reinforcement speciation. Using windowed scans of various population genetic statistics to identify signatures of reinforcement, we find 184 candidate genes associated with a variety of functions, including an overrepresentation of multiple neurological functions and several genes involved in sexual development and gametogenesis. These results are consistent with a variety of genes acting in a reinforcement process between these species. We also find signatures of introgression of the Y‐chromosome that confirm previous studies suggesting male‐driven introgression ofM. mulattaintoM. fascicularispopulations. This study uses WGS to find evidence of the process of reinforcement in primates that have medical and conservation relevance.
Synthesis of Donor Substituted Chlorophyll Derivatives for Applications in Dye Sensitized Solar Cells
Authors: Conrad‐Fletemeyer Ulf , Dononelli Wilke , Müller‐Bork Caroline , Stelten Johannes , Montforts Franz‐Peter 
Published: October 2023

AbstractOrganic dyes based on chlorophyll derivatives were synthesized and investigated with respect to applications in dye sensitized solar cells (DSSC). Cyanobacterium Spirulina platensis cultivated on large scales in tropical areas around the Pacific Ocean is an attractive source for production and isolation of pure chlorophyll a. Direct transformation of chlorophyll a into very robust chlorin e6 trimethylester 3 affords an ideal platform for synthesis of dyes for artificial photosynthesis. A series of molecules 24–32 with donor‐π‐acceptor structures and functional groups for immobilization on TiO2 were achieved by subsequent synthetic modifications of 3. Photochemical, theoretical and electrochemical properties of dyes were investigated and their sensitized solar cells performances studied after immobilization on TiO2.