bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant‐derived exosomes extracted from Lycium barbarum L. loaded with isoliquiritigenin to promote spinal cord injury repair based on 3D printed bionic scaffold
Authors: Wang Qilong , Liu Kai , Cao Xia , Rong Wanjin , Shi Wenwan , Yu Qintong , Deng Wenwen , Yu Jiangnan , Xu Ximing 
Published: January 2024

AbstractPlant‐derived exosomes (PEs) possess an array of therapeutic properties, including antitumor, antiviral, and anti‐inflammatory capabilities. They are also implicated in defensive responses to pathogenic attacks. Spinal cord injuries (SCIs) regeneration represents a global medical challenge, with appropriate research concentration on three pivotal domains: neural regeneration promotion, inflammation inhibition, and innovation and application of regenerative scaffolds. Unfortunately, the utilization of PE in SCI therapy remains unexplored. Herein, we isolated PE from the traditional Chinese medicinal herb, Lycium barbarum L. and discovered their inflammatory inhibition and neuronal differentiation promotion capabilities. Compared with exosomes derived from ectomesenchymal stem cells (EMSCs), PE demonstrated a substantial enhancement in neural differentiation. We encapsulated isoliquiritigenin (ISL)‐loaded plant‐derived exosomes (ISL@PE) from L. barbarum L. within a 3D‐printed bionic scaffold. The intricate construct modulated the inflammatory response following SCI, facilitating the restoration of damaged axons and culminating in ameliorated neurological function. This pioneering investigation proposes a novel potential route for insoluble drug delivery via plant exosomes, as well as SCI repair. The institutional animal care and use committee number is UJS‐IACUC‐2020121602.
13Cβ‐Valine and 13Cγ‐Leucine Methine Labeling To Probe Protein Ligand Interaction
Authors: Toscano Giorgia , Höfurthner Theresa , Nagl Benjamin , Beier Andreas , Mayer Moriz , Geist Leonhard , McConnell Darryl B. , Weinstabl Harald , Konrat Robert , Lichtenecker Roman J. 
Published: January 2024

AbstractPrecise information regarding the interaction between proteins and ligands at molecular resolution is crucial for effectively guiding the optimization process from initial hits to lead compounds in early stages of drug development. In this study, we introduce a novel aliphatic side chain isotope‐labeling scheme to directly probe interactions between ligands and aliphatic sidechains using NMR techniques. To demonstrate the applicability of this method, we selected a set of Brd4‐BD1 binders and analyzed 1H chemical shift perturbation resulting from CH‐π interaction of Hβ‐Val and Hγ‐Leu as CH donors with corresponding ligand aromatic moieties as π acceptors.
Carbon quantum dots modified and Y3+ doped Ni3(NO3)2(OH)4 nanospheres with excellent battery‐like supercapacitor performance
Authors: Gao Jiamin , Xie Huidong , Zuo Feng , Liu Hu , Zhao Yajuan , Yang Chang 
Published: January 2024

AbstractSupercapacitor is an important energy storage device widely used in the automobile industry, military production, and communication equipment because of its fast charge‐discharge rate, and high power density. Herein, carbon quantum dots modified and Y3+ doped Ni3(NO3)2(OH)4 (NiY@CQDs) nanospheres are prepared by a solvothermal method and used as an electrode material. The electrochemical properties of NiY@CQDs were measured in a three‐electrode system. An asymmetric supercapacitor (ASC) cell was assembled with activated carbon (AC) as the anode and NiY@CQDs as the cathode. The electrochemical properties of the ASC device were measured in a two‐electrode system. Experimental results show the shape of NiY@CQDs is petal‐shaped and the introducing carbon quantum dots and doping Y3+ significantly increases the specific surface area, conductivity, and specific capacitance of Ni3(NO3)2(OH)4. The mass‐specific capacitance of NiY@CQDs reaches up to 2944 F g−1 at a current density of 1 A g−1. The asymmetric supercapacitor of NiY@CQDs//AC has a high energy density of 138.65 Wh kg−1 at a power density of 1500 W kg−1, displaying a wide range of application prospects in the energy storage area.
Stereocontrol via Propeller Chirality in FLP‐Catalyzed Asymmetric Hydrogenation
Authors: Kótai B. , Laczkó G. , Hamza A. , Pápai I. 
Published: January 2024

AbstractUtilization of chiral frustrated Lewis pairs as catalysts in enantioselective hydrogenation of unsaturated molecules represents a promising approach in asymmetric synthesis. In our effort to improve our current understanding of the factors governing the stereoselectivity in these catalytic processes, herein we examined the mechanism of direct hydrogenation of aromatic enamines catalyzed by a binaphthyl–based chiral amino–borane. Our computational analysis reveals that only one particular conformer of the key borohydride reaction intermediate can be regarded as a reactive form of this species. This borohydride conformer has a well–defined chiral propeller shape, which induces facial selectivity in the hydride transfer to pro–chiral iminium intermediates. The propeller chirality of the reactive borohydride conformer is generated by the axially chiral binaphthyl scaffold of the amino–borane catalyst through stabilizing π‐π stacking interactions. This new computational insight can be readily used to interpret the high degree of stereoinduction observed for these reactions. We expect that the concept of chirality relay could be further exploited in catalyst design endeavors.
Continuous fixed‐bed column adsorption of nickel (II) using recyclable three‐dimensional cellulose nanocrystals‐hydrogel: Bed depth service time, Thomas, Adams–Bohart, and Yoon–Nelson modelling
Authors: Claude Banza Jean , Onyango Maurice Stephane 
Published: January 2024

AbstractHeavy metal ions have detrimental impacts on both the environment and human health. Therefore, it is necessary to develop simple, economical water treatment adsorbents that employ easily modifiable, organic, biodegradable polymers like cellulose nanocrystals. This work used Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X‐ray diffraction (XRD), and Brunauer–Emmett–Teller (BET) to characterize the cellulose nanocrystal hydrogel prepared to remove Ni2+. The hydrogel was established to have two stable degradation points, ranging from 70 to 120°C to 250 to 380°C. Additionally, the principal functionalized groups observed in the hydrogel's molecular structure were CH, OH, and CO, which were uniform distribution and finger‐like structures as seen by SEM. It consisted of crystalline and amorphous structures, as shown by XRD patterns, making it a viable option for water filtration. BET showed that the surface area of the hydrogel increased upon modification. The column study involves optimization of pH, flow rate, concentration, and bed depth. According to experimental data, the effects of breakthrough parameters including pH (4, 5, 6) influent concentration (50, 75, and 100 mg/L), feed flow rate (5, 10, and 15 mL/min), and bed height (10, 15, and 20 cm). With an adsorption capacity of 58.65 mg/g, a flow rate of 10 mL/min, a bed depth of 20 cm, an influent concentration of 75 mg/L and a pH of 5 was found. The column experimental data fitted better to the Thomas, Yoon–Nelson, and bed depth service time modelling (R2 > 0.99) than the Adams–Bohart model with R2 > 0.90. The adsorbent is economical and environmentally friendly due to its excellent regeneration capacity.
Effective inhibition of crystal growth during wax deposition using CTAB‐grafted faujasite nanoparticles
Authors: Al‐Shboul Tamer , Hethnawi Afif , Sagala Farad , Nassar Nashaat N. 
Published: January 2024

AbstractIn this work, we developed cetrimonium bromide (CTAB)‐grafted faujasite nanoparticles (C‐g‐F) as wax inhibitors for the deposits that were formed from a model oil system consisting of 5 wt.% paraffin wax in toluene. Our developed nanomaterials were fully characterized, hydrophobically modified, and their deposition inhibition performance compared with virgin CTAB was investigated in a model waxy oil through cold finger setup (CF), differential scanning calorimetry (DSC), cold flow yield strength, and cross‐polarized microscopy (CPM). Applying our nano‐inhibitors at a concentration of 100 ppm led to more than 50 wt.% inhibition and a 30% reduction of deposit cold yield strength. Interestingly, the presence of FAU nanoparticles in the core structure of C‐g‐F contributed to better dispersibility, enhancing surface wettability (reducing interfacial tension with wax crystals), facilitating inhibitions, and preventing co‐crystallization greater than the surfactant alone. The morphological analysis results showed that C‐g‐F, due to their novel surface features, could suppress the unordered wax crystals from networking, resulting in uniform spherical‐like wax aggregates. Hence, the application of tiny concentrations of C‐g‐F (10 to 300 ppm) outperformed stand‐alone surfactants in nucleating the wax crystals.
Intrinsic kinetic model with variable light intensity of the emerging pollutants degradation in a photocatalytic differential reactor with immobilized TIO2: Experiments and CFD
Authors: Balestrin Evandro , de Souza Selene Maria Arruda Guelli Ulson , Valle José Alexandre Borges , da Silva Adriano 
Published: January 2024

AbstractHeterogeneous photocatalysis is an alternative to mineralizing emerging pollutants. The present study focuses on the kinetic model of salicylic acid photocatalytic degradation in an aqueous solution as a function of pollutant concentration and light intensity. The intrinsic kinetic model parameters were determined using a differential photocatalytic reactor with immobilized TiO2 based on experiments and numerical simulations. Five degradation experiments with different light intensities were performed for a turbulent flow rate of 4.7 L/min and salicylic acid concentration of 20 mg/L. Light intensities used for the kinetic experiments were obtained by computational fluid dynamics (CFD) simulation using the radiation transfer equation that was pre‐validated. The TiO2 immobilized method presents low leaching of the catalyst and good degradation efficiency. The intrinsic kinetic model showed to be first‐order both for the pollutant concentration and for the light intensity and can be applied in simulation to optimize and design photocatalytic reactors.
Stress‐related fluctuations in personality functioning in daily life: Pilot data from an ambulatory monitoring study in outpatients diagnosed with borderline personality disorder
Authors: Sinnaeve Roland , Van Diest Ilse , Claes Stephan , Myin‐Germeys Inez , Van den Bosch Louisa M. C. , Kamphuis Jan Henk , Vansteelandt Kristof , Van Hoof Chris , Cornelis Jan , Houben Marlies 
Published: January 2024

AbstractThis pilot study aimed to test a comprehensive experience sampling method (ESM) protocol for investigating the relationship between stress and personality functioning (PF) in the daily lives of outpatients diagnosed with borderline personality disorder (BPD). Participants (N = 22) responded to a 32‐item ESM questionnaire 10 times a day for 1 week while wearing two stress detection devices. Results showed that the protocol was feasible. There was a high level of compliance (i.e. average of 85%), and no serious adverse events. The main indices, that is, Stress and PF, demonstrated acceptable to excellent internal consistency and provisional evidence for their validity. We found that 64% of the variability in PF was due to within‐subject differences. Mixed modelling showed that the momentary changes in stress (p < .001) and body position (i.e. active vs passive; p < .001) explained an estimated 46% of this within‐subject variance. We found no significant within‐subject effects when we used parameters of autonomic nervous system (ANS)–activity as predictors. Data loss during recording and artefact detection of electrophysiological data were substantial but not related to momentary changes in PF. The preliminary findings suggest that PF is a volatile aspect of personality pathology and that there is a strong, concurrent relationship between stress and PF in daily life. This pilot study constitutes the first demonstration of PF fluctuations within a clinical sample and initiates an examination of their association with ANS activity.
Anatomical three‐dimensional model with peri‐implant defect for in vitro assessment of dental implant decontamination
Authors: Khan Sadia Nazir , Koldsland Odd Carsten , Tiainen Hanna , Hjortsjö Carl 
Published: January 2024

AbstractObjectivesAccess to the implant surface plays a significant role in effective mechanical biofilm removal in peri‐implantitis treatment. Mechanical decontamination may also alter the surface topography of the implant, potentially increasing susceptibility to bacterial recolonization. This in vitro study aimed to evaluate a newly developed, anatomically realistic, and adaptable three‐dimensional (3D)printed model with a peri‐implant bone defect to evaluate the accessibility and changes of dental implant surfaces after mechanical decontamination treatment.Material and MethodsA split model of an advanced peri‐implant bone defect was prepared using 3D printing. The function of the model was tested by mechanical decontamination of the exposed surface of dental implants (Standard Implant Straumann AG) coated with a thin layer of colored occlusion spray. Two different instruments for mechanical decontamination were used. Following decontamination, the implants were removed from the split model and photographed. Image analysis and fluorescence spectroscopy were used to quantify the remaining occlusion spray both in terms of area and total amount, while scanning electron microscopy and optical profilometry were used to analyze alteration in the implant surface morphology.ResultsThe 3D model allowed easy placement and removal of the dental implants without disturbing the implant surfaces. Qualitative and quantitative assessment of removal of the occlusion spray revealed differences in the mechanism of action and access to the implant surface between tested instruments. The model permitted surface topography analysis following the decontamination procedure.ConclusionThe developed 3D model allowed a realistic simulation of decontamination of implant surfaces with colored occlusion spray in an advanced peri‐implant defect. 3D printing allows easy adaptation of the model in terms of the shape and location of the defect. The model presents a valuable tool for in vitro investigation of the accessibility and changes of the implant surface after mechanical and chemical decontamination.
Endometriosis first presenting in pleural fluid cytology
Authors: Chen‐Yost Heather I. , Huang Tao , O'Brien Kathleen , Weir William , Reddy Rishindra M. , Lieberman Richard , Pang Judy 
Published: January 2024

AbstractMost patients with thoracic endometriosis present with catamenial pneumothorax, a rare condition in which recurrent episodes occur within 72 h before or after the start of menstruation. We report a case of thoracic endometriosis presenting with recurrent bloody pleural effusions without pneumothorax diagnosed on pleural fluid cytology. We describe the cytomorphology and immunoprofile of thoracic endometriosis and discuss the differential diagnoses, including neoplastic processes. We also highlight the importance of communication with clinicians for timeliness of diagnosis and treatment, especially when thoracic endometriosis is not suspected.
Lesser prairie‐chicken dispersal after translocation: Implications for restoration and population connectivity
Authors: Berigan Liam A. , Aulicky Carly S. H. , Teige Elisabeth C. , Sullins Daniel S. , Fricke Kent A. , Reitz Jonathan H. , Rossi Liza G. , Schultz Kraig A. , Rice Mindy B. , Tanner Evan , Fuhlendorf Samuel D. , Haukos David A. 
Published: January 2024

AbstractConservation translocations are frequently inhibited by extensive dispersal after release, which can expose animals to dispersal‐related mortality or Allee effects due to a lack of nearby conspecifics. However, translocation‐induced dispersals also provide opportunities to study how animals move across a novel landscape, and how their movements are influenced by landscape configuration and anthropogenic features. Translocation among populations is considered a potential conservation strategy for lesser prairie‐chickens (Tympanuchus pallidicinctus). We determined the influence of release area on dispersal frequency by translocated lesser prairie‐chickens and measured how lesser prairie‐chickens move through grassland landscapes through avoidance of anthropogenic features during their dispersal movements. We translocated 411 lesser prairie‐chickens from northwest Kansas to southeastern Colorado and southwestern Kansas in 2016–2019. We used satellite GPS transmitters to track 115 lesser prairie‐chickens throughout their post‐release dispersal movements. We found that almost all lesser prairie‐chickens that survived from their spring release date until June undergo post‐translocation dispersal, and there was little variation in dispersal frequency by release area (96% of all tracked birds, 100% in Baca County, Colorado, 94% in Morton County, Kansas, n = 55). Dispersal movements (male: 103 ± 73 km, female: 175 ± 108 km, n = 62) led to diffusion across landscapes, with 69% of birds settling >5 km from their release site. During dispersal movements, translocated lesser prairie‐chickens usually travel by a single 3.75 ± 4.95 km dispersal flight per day, selecting for steps that end far from roads and in Conservation Reserve Program (CRP) grasslands. Due to this “stepping stone” method of transit, landscape connectivity is optimized when <5 km separates grassland patches on the landscape. Future persistence of lesser prairie‐chicken populations can be aided through conservation of habitat and strategic placement of CRP to maximize habitat connectivity. Dispersal rates suggest that translocation is better suited to objectives for regional, rather than site‐specific, population augmentation for this species.
Cooler and drier conditions increase parasitism in a subtropical damselfly population
Authors: Paul Shatabdi , Rayhan Mostakim , Herberstein Marie E. , Khan Md Kawsar 
Published: January 2024

AbstractHost–parasite interactions are impacted by climate, which may result in variation of parasitism across landscapes and time. Understanding how parasitism varies across these spatio‐temporal scales is crucial to predicting how organisms will respond to and cope under a rapidly changing climate. Empirical work on how parasitism varies across climates is limited. Here, we examine the variation of parasitism across seasons and identify the likely climatic factors that explain this variation using Agriocnemis femina damselflies and Arrenurus water mite ectoparasites as a host–parasite study system. We assessed parasitism in a natural population in Sylhet, Bangladesh which is located in subtropical climate between 2021 and 2023. We calculated prevalence (proportion of infected individuals) and intensity (the number of parasites on an infected individual) of parasitism across different seasons. Parasite prevalence and intensity were greater during cooler seasons (autumn and winter) compared to hotter seasons (spring and summer). Mean temperature and precipitation were negatively correlated with parasite prevalence, whereas only mean precipitation was negatively correlated with parasite intensity. Tropical, subtropical and mediterranean regions are predicted to experience extreme climatic events (extreme temperature, less precipitation and frequent drought) as a consequence of anthropogenic climate change, and our finding suggests that this might alter patterns of parasitism in aquatic insects.
Factors influencing the detection and occupancy of little brown bats (Myotis lucifugus)
Authors: Hohoff Tara C. , Deppe Jill L. 
Published: January 2024

AbstractUsing acoustics to survey for bats has increased as the need for data on increasingly rare species has also increased. We set out to better understand the difference between mist netting and acoustic detection probabilities between these two methods for the little brown bat (Myotis lucifugus), a species highly impacted by white‐nose syndrome and currently considered for federal listing in the United States. We also analyzed occupancy relationships with local and landcover variables. We surveyed 15 sites using mist netting paired with an acoustic recorder for multiple nights to estimate detection probability of this species. We also deployed acoustic recorders at another 73 sites. We found that detection rates for mist netting were very low but increased with day of year and decreased from proximity to water. Acoustic surveys had higher detection rates, but there was an approximately 30% likelihood of false‐positive detections. At the mean distance to water and day of year, acoustic surveys had a detection rate 55 times higher than mist netting. There were not significant factors influencing occupancy of little brown bats, only a slight positive relationship between forested largest patch, landscape patch richness and forest basal area. Given the declines in little brown bat populations since white‐nose syndrome, it is even more critical that we consider the very low detection rate of mist netting compared to acoustic surveys.
Association between secondhand smoke exposure and incident heart failure: The Multi‐Ethnic Study of Atherosclerosis (MESA)
Authors: Lin Gen‐Min , Lloyd‐Jones Donald M. , Colangelo Laura A. , Lima Joao A.C. , Szklo Moyses , Liu Kiang 
Published: January 2024

AimsThere are no studies on the association between secondhand smoke (SHS) exposure and incident heart failure (HF). This cohort study aimed to examine the associations of self‐reported and urinary cotinine‐assessed SHS exposure with incident HF.Methods and resultsThis study included 5548 non‐active smoking participants aged 45–84 years and free of known cardiovascular diseases and HF at baseline who self‐reported SHS exposure time in the Multi‐Ethnic Study of Atherosclerosis (MESA) at baseline (2000–2002). A cohort subset of 3376 non‐active smoking participants underwent urinary cotinine measurements. HF events were verified by medical records or death certificates and ascertained from baseline through 2019. Multivariable Cox proportional hazards regression analysis was used with adjustment for demographic variables, traditional cardiovascular risk factors, physical activity, tobacco pack‐years and medications. During a median follow‐up of 17.7 years, 353 and 196 HF events were identified in the self‐report cohort and cohort subset, respectively. In the self‐report cohort, compared with the SHS unexposed group (0 h/week), the highest tertile of the SHS exposed group (7–168 h/week) was not associated with incident HF (hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.49–1.00; p = 0.052). In contrast, in the cohort subset, participants with detectable urinary cotinine >7.07 ng/ml had a higher risk of incident HF than those with undetectable urinary cotinine ≤7.07 ng/ml (HR 1.45, 95% CI 1.03–2.06; p = 0.034). There were no significant heterogeneities in HF risk by age, sex, race/ethnicity, or past smoking status.ConclusionSecondhand smoke exposure reflected by modestly increased urinary cotinine (>7.07 ng/ml) rather than self‐report in non‐active smokers was associated with a 40–50% higher risk of any HF event.