bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated Hypofractionated Chemoradiation Followed by Stereotactic Ablative Radiotherapy Boost for Locally Advanced, Unresectable Non–Small Cell Lung Cancer
Authors: Wu Trudy C. , Luterstein Elaine , Neilsen Beth K. , Goldman Jonathan W. , Garon Edward B. , Lee Jay M. , Felix Carol , Cao Minsong , Tenn Stephen E. , Low Daniel A. , Kupelian Patrick A. , Steinberg Michael L. , Lee Percy 
Published: January 2024

ImportanceIntrathoracic progression remains the predominant pattern of failure in patients treated with concurrent chemoradiation followed by a consolidation immune checkpoint inhibitor for locally advanced, unresectable non–small cell lung cancer (NSCLC).ObjectiveTo determine the maximum tolerated dose (MTD) and use of hypofractionated concurrent chemoradiation with an adaptive stereotactic ablative radiotherapy (SABR) boost.Design, Setting, and ParticipantsThis was an early-phase, single-institution, radiation dose-escalation nonrandomized controlled trial with concurrent chemotherapy among patients with clinical stage II (inoperable/patient refusal of surgery) or III NSCLC (American Joint Committee on Cancer Staging Manual, seventh edition). Patients were enrolled and treated from May 2011 to May 2018, with a median patient follow-up of 18.2 months. Patients advanced to a higher SABR boost dose if dose-limiting toxic effects (any grade 3 or higher pulmonary, gastrointestinal, or cardiac toxic effects, or any nonhematologic grade 4 or higher toxic effects) occurred in fewer than 33% of the boost cohort within 90 days of follow-up. The current analyses were conducted from January to September 2023.InterventionAll patients first received 4 Gy × 10 fractions followed by an adaptive SABR boost to residual metabolically active disease, consisting of an additional 25 Gy (low, 5 Gy × 5 fractions), 30 Gy (intermediate, 6 Gy × 5 fractions), or 35 Gy (high, 7 Gy × 5 fractions) with concurrent weekly carboplatin/paclitaxel.Main Outcome and MeasureThe primary outcome was to determine the MTD.ResultsData from 28 patients (median [range] age, 70 [51-88] years; 16 [57%] male; 24 [86%] with stage III disease) enrolled across the low- (n = 10), intermediate- (n = 9), and high- (n = 9) dose cohorts were evaluated. The protocol-specified MTD was not exceeded. The incidences of nonhematologic acute and late (&amp;gt;90 days) grade 3 or higher toxic effects were 11% and 7%, respectively. No grade 3 toxic effects were observed in the intermediate-dose boost cohort. Two deaths occurred in the high-dose cohort. Two-year local control was 74.1%, 85.7%, and 100.0% for the low-, intermediate-, and high-dose cohorts, respectively. Two-year overall survival was 30.0%, 76.2%, and 55.6% for the low-, intermediate-, and high-dose cohorts, respectively.Conclusions and RelevanceThis early-phase, dose-escalation nonrandomized controlled trial showed that concurrent chemoradiation with an adaptive SABR boost to 70 Gy in 15 fractions with concurrent chemotherapy is a safe and effective regimen for patients with locally advanced, unresectable NSCLC.Trial RegistrationClinicalTrials.gov Identifier: NCT01345851
Fluorine‐Containing Phase‐Separated Polymer Electrolytes Enabling High‐Energy Solid‐State Lithium Metal Batteries
Authors: Han Junghun , Lee Michael J. , Min Ju Hong , Kim Keun Hee , Lee Kyungbin , Kwon Seung Ho , Park Jinseok , Ryu Kun , Seong Hyeonseok , Kang Hyewon , Lee Eunji , Lee Seung Woo , Kim Bumjoon J. 
Published: January 2024

AbstractSolid‐state lithium (Li) metal batteries (LMBs) have been developed as a promising replacement for conventional Li‐ion batteries due to their potential for higher energy. However, the current solid‐state electrolytes used in LMBs have limitations regarding mechanical and electrochemical properties and interfacial stability. Here, a fluorine (F)‐containing solid polymer electrolyte (SPE) having a bi‐continuous structure of F‐containing elastomers and plastic crystals is reported. The trifluoroethyl acrylate‐based SPE (T‐SPE) exhibits high ionic conductivity over 10−3 S cm−1, superior mechanical elasticity, and robust LiF‐rich interphases at both the Li metal anode and the LiNi0.83Mn0.06Co0.11O2 cathode. Full cells with thin T‐SPEs and low negative/positive capacity ratios below 0.5 at the high‐operating voltage of 4.5 V demonstrate a high specific energy of 538 Wh kganode+cathode+electrolyte−1 and maintain 393 Wh kg−1 at a high specific power of 804 W kganode+cathode+electrolyte−1. The F‐containing phase‐separated SPE system provides a powerful strategy for achieving high‐energy and ‐power solid‐state LMBs.
P‐Type PbS Quantum Dot Solar Ink via Hydrogen‐Bonding Modulated Solvation for High‐Efficiency Photovoltaics
Authors: Wang Chao , Wu Qi , Wang Yinglin , Wang Zihan , Li Hao , Li Xiaofei , Chen Xiangshan , Wang Changhua , Liu Yichun , Zhang Xintong 
Published: January 2024

AbstractLigand modulation of the electrical properties and surface solvation plays a crucial role in the development of functionalized colloidal quantum dots (CQDs) inks for solution‐processed optoelectronics. While inorganic halide ionic ligands can facilitate the n‐type doping of PbS CQDs and establish an electrical double layer in polar solvents for stable high‐concentration n‐type CQD inks, a plausible solvation strategy is still lacking to stabilize p‐type PbS CQDs, thereby resulting in a tedious multi‐step deposition involving short‐chain dithiol molecular ligands for advanced heterojunction CQD solar cells. Here an effective hydrogen bonding solvation strategy is proposed using 2‐mercaptoethanol (ME) ligands to realize stable p‐type PbS CQD ink. This strategy enables DMSO to form a dense solvation layer surrounding the ME‐modified PbS CQDs. With this approach, the PbS‐ME CQD ink exhibits a photoluminescence quantum yield of 52.03%, which is the highest record for PbS CQD inks. Finally, one‐step deposition of a p‐type PbS‐ME layer for PbS CQD photovoltaics is successfully achieved with an impressive power conversion efficiency (PCE) of 10.91%. This p‐type solar ink facilitates the fabrication of ready‐to‐use devices, enabling extensive applications in large‐scale and flexible optoelectronic devices.
An Intelligent and Soluble Microneedle Composed of Bi/BiVO4 Schottky Heterojunction for Tumor Ct Imaging and Starvation/Gas Therapy‐Promoted Synergistic Cancer Treatment
Authors: Hu Tingting , Jia Lu , Li Heng , Yang Chunyu , Yan Yuening , Lin Huiming , Zhang Feng , Qu Fengyu , Guo Wei 
Published: January 2024

AbstractPhototherapy and sonodynamic therapy (SDT) are widely used for the synergistic treatment of tumors and have received considerable attention. However, an inappropriate tumor microenvironment, including pH, H2O2, oxygen, and glutathione levels, can reduce the therapeutic effects of synergistic phototherapy and SDT. Here, a novel Bi‐based soluble microneedle (MN) is designed for the CT imaging of breast tumors and starvation therapy/gas therapy‐enhanced phototherapy/SDT. The optimized Bi/BiVO4 Schottky heterojunction serves as the tip of the MN, which not only has excellent photothermal conversion ability and CT contrast properties, but its heterojunction can also avoid the rapid combination of electrons and hole pairs, thereby enhancing the photodynamic/sonodynamic effects. A degradable MN with excellent mechanical properties is fabricated by optimizing the ratios of poly(vinyl alcohol), poly(vinyl pyrrolidone), and sodium hyaluronate. Glucose oxidase (GOx) and diallyl trisulfide are loaded into the MN to achieve tumor starvation and gas therapy, respectively; And the controlled release of GOx and H2S can be achieved under ultrasound or near‐infrared laser irradiation. The in vitro and in vivo results demonstrate that this multifunctional MN can achieve high therapeutic efficacy through starvation therapy/gas therapy‐enhanced phototherapy/SDT. The designed multifunctional MN provides a prospective approach for synergistic phototherapy and SDT.
Negative Photoconductivity of Fe3GeTe2 Crystal with Native Heterostructure for Ultraviolet to Terahertz Ultra‐Broadband Photodetection
Authors: Ma Suping , Li Guanghao , Li Zhuo , Wang Tingyuan , Zhang Yawen , Li Ningning , Chen Haisheng , Zhang Nan , Liu Weiwei , Huang Yi 
Published: January 2024

AbstractGaining insight into the photoelectric behavior of ferromagnetic materials is significant for comprehensively grasping their intrinsic properties and broadening future application fields. Here, through a specially designed Fe3GeTe2/O‐Fe3GeTe2 heterostructure, first, the broad‐spectrum negative photoconductivity phenomenon of ferromagnetic nodal line semimetal Fe3GeTe2 is reported that covers UV–vis‐infrared‐terahertz bands (355 nm to 3000 µm), promising to compensate for the inadequacies of traditional optoelectronic devices. The significant suppression of photoexcitation conductivity is revealed to arise from the semimetal/oxidation (sMO) interface‐assisted dual‐response mechanism, in which the electron excitation origins from the semiconductor photoconductivity effect in high‐energy photon region, and semimetal topological band‐transition in low‐energy photon region. High responsivities ranging from 103 to 100 mA W−1 are acquired within ultraviolet‐terahertz bands under ±0.1 V bias voltage at room temperature. Notably, the responsivity of 2.572 A W−1 at 3000 µm (0.1 THz) and the low noise equivalent power of 26 pW Hz−1/2 surpass most state‐of‐the‐art mainstream terahertz detectors. This research provides a new perspective for revealing the photoelectric conversion properties of Fe3GeTe2 crystal and paves the way for the development of spin‐optoelectronic devices.
Upconversion 3D Bioprinting for Noninvasive In Vivo Molding
Authors: Zhang Peng , Teng Zhaowei , Zhou Min , Yu Xue , Wen Hongyu , Niu Junzheng , Liu Zhichao , Zhang Zhimeng , Liu Yang , Qiu Jianbei , Xu Xuhui 
Published: January 2024

AbstractTissue engineered bracket materials provide essential support for the physiological protection and therapeutics of patients. Unfortunately, the implantation process of such devices poses the risk of surgical complications and infection. In this study, an upconversion nanoparticles (UCNPs)‐assisted 3D bioprinting approach is developed to realize in vivo molding that is free from invasive surgery. Reasonably designed UCNPs, which convert near‐infrared (NIR) photons that penetrate skin tissues into blue–violet emission (300–500 nm), induce a monomer polymerization curing procedure in vivo. Using a fused deposition modeling coordination framework, a precisely predetermined trajectory of the NIR laser enables the manufacture of implantable medical devices with tailored shapes. A proof of the 3D bioprinting of a noninvasive fracture fixation scaffold is achieved successfully, thus demonstrating an entirely new method of in vivo molding for biomedical treatment.
Unveiling Cutting‐Edge Developments in Electrocatalytic Nitrate‐to‐Ammonia Conversion
Authors: Zhang Haoran , Wang Haijian , Cao Xiqian , Chen Mengshan , Liu Yuelong , Zhou Yingtang , Huang Ming , Xia Lu , Wang Yan , Li Tingshuai , Zheng Dongdong , Luo Yongsong , Sun Shengjun , Zhao Xue , Sun Xuping 
Published: January 2024

AbstractThe excessive enrichment of nitrate in the environment can be converted into ammonia (NH3) through electrochemical processes, offering significant implications for modern agriculture and the potential to reduce the burden of the Haber–Bosch (HB) process while achieving environmentally friendly NH3 production. Emerging research on electrocatalytic nitrate reduction (eNitRR) to NH3 has gained considerable momentum in recent years for efficient NH3 synthesis. However, existing reviews on nitrate reduction have primarily focused on limited aspects, often lacking a comprehensive summary of catalysts, reaction systems, reaction mechanisms, and detection methods employed in nitrate reduction. This review aims to provide a timely and comprehensive analysis of the eNitRR field by integrating existing research progress and identifying current challenges. This review offers a comprehensive overview of the research progress achieved using various materials in electrochemical nitrate reduction, elucidates the underlying theoretical mechanism behind eNitRR, and discusses effective strategies based on numerous case studies to enhance the electrochemical reduction from NO3˗ to NH3. Finally, this review discusses challenges and development prospects in the eNitRR field with an aim to guide design and development of large‐scale sustainable nitrate reduction electrocatalysts.
Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy
Authors: Li Xin , Shen Meili , Yang Jie , Liu Linlin , Yang Ying‐Wei 
Published: January 2024

AbstractCancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, and starvation therapy, are applied to cancer treatment, their limited therapeutic effect, severe side effects, and unsatisfactory drug release behavior need to be carefully considered. Thus, there is an urgent need to develop efficient drug delivery strategies for improving cancer treatment efficacy and realizing on‐demand drug delivery. Notably, pillararenes, as an emerging class of supramolecular macrocycles, possess unique properties of highly tunable structures, superior host–guest chemistry, facile modification, and good biocompatibility, which are widely used in cancer therapy to achieve controllable drug release and reduce the toxic side effects on normal tissues under various internal/external stimuli conditions. This review summarizes the recent advance of stimuli‐responsive supramolecular delivery systems (SDSs) based on pillararenes for tumor therapy from the perspectives of different assembly methods and hybrid materials, including molecular‐scale SDSs, supramolecular nano self‐assembly delivery systems, and nanohybrid SDSs. Moreover, the prospects and critical challenges of stimuli‐responsive SDSs based on pillararenes for cancer therapy are also discussed.
B(C6F5)3‐Catalyzed N‐Allylation of Hydrazines with Allylic Alcohols
Authors: Xu Boxia , Yang Ji , Yao Zhen , Yang Zhuo , Liu Kai , Jin Xing , Xu Lijin , Shi Qian 
Published: January 2024

AbstractAn N‐allylation of monosubstituted acyl hydrazines with allylic alcohols has been developed by using B(C6F5)3 catalysis. This protocol allows for convenient access to various synthetically useful N‐allylated hydrazine products in 48–96% yields with broad substrate scope and wide functional group compatibility. The operationally simple reaction proceeds without calling for stringent removal of air and moisture, and can be readily scaled up to gram scale. Preliminary mechanistic studies support the generation of an allylic carbon cation that is involved in the catalytic cycle, and the reaction proceeds via the in situ formation of diallyl ethers as intermediates.
A Novel Data‐Driven Approach to Lithium‐ion Battery Dynamic Charge State Capture for New Energy Electric Vehicles
Authors: Zheng Li , Huang Hao , Liu Ruxiang , Man Jianlin , Shi Yusong , Du Huiping , Du Li 
Published: January 2024

AbstractAs lithium‐ion batteries are the main power source of new energy vehicles, making accurate predictions of unknown State of Charge (SOC) during vehicle operation for vehicle data monitoring is vital to the advancement of intelligent new energy vehicles. In this manuscript, an expression tree‐based genetic programming regression model (ETGPR) is proposed to estimate the real‐time SOC of lithium‐ion batteries. The proposed model mainly adopts the symbolic regression technique. In addition to the current–voltage curves being fed into the model, an additional approach is designed to ensure real‐time model predictions in dynamic situations, which includes the previous moment's power in the input parameters. Different seed hyperparameters in the model are set, and the model automatically performs evolutionary calculations. Subsequently, each parameter of the model is optimally adjusted to obtain a set of regression expressions that accurately reflect the relationship between the SOC and each parameter after a specified number of iterations. Finally, the generated expression is proven to perform better in terms of its ability to capture the nonlinear relationship between SOC and battery variables. Also, the model demonstrates excellent robustness in the presence of notable noise from input‐independent features compared to other models, a root mean square error (RMSE) of less than 0.3% and a mean absolute error (MAE) of less than 0.2% are achieved. Furthermore, the potential of the model's implement‐ability under variable temperature and real driving data conditions is verified.
Enhancing Self‐Powered Terahertz Photodetection with VSe2 and Van Der Waals Heterostructure Integration via Photothermoelectric Effect
Authors: Jiang Mengjie , Pan Xiaokai , Zhang Kaixuan , Tian Shijian , Zhang Libo , Han Li , He Yuan , Lv Xuyang , Lan Shiqi , Xing Huaizhong , Wang Lin 
Published: January 2024

AbstractOwning unique optical and electronic properties, two dimensional (2D) materials have made remarkable strides in the field of photodetection applications. However, achieving highly sensitive and ultra‐broadband detection from microwave to terahertz (THz) range (0.02–0.54 THz) remains a significant challenge for photodetectors. This study presents a self‐powered THz photodetector based on VSe2 and its van der Waals heterostructure. The photoresponse of the photodetector is primarily attributed to the photothermoelectric effect. At room temperature, the device exhibits lower noise equivalent power values of 21 pW Hz−1/2 at 0.28 THz. This work has achieved ultra‐broadband detection and demonstrated the potential for large‐area imaging, providing a new avenue for the application of THz technology in nondestructive testing and biometric identification fields.
Navigating the challenges of building a more resilient infant formula industry
Authors: Yenerall Jackie , Muhammad Andrew , DeLong Karen , Malone Trey 
Published: January 2024

AbstractIn 2022, U.S. consumers experienced an infant formula shortage that resulted in historic out‐of‐stock rates and brought renewed attention to market concentration in the infant formula market. FDA regulation, tariffs, and limiting WIC benefit redemption to a state's contract brand of infant formula, all potential barriers to competition, were temporarily relaxed to mitigate the impact of the shortage. This article discusses the potential trade‐offs associated with permanent policy changes while highlighting opportunities for future research to support the development of policies to improve resiliency in the infant formula market.
Oil spill soil remediation using thermal desorption: Project synthesis and outcomes
Authors: O'Brien Peter L. , DeSutter Thomas M. , Casey Francis X. M. , Wick Abbey , Bartsch Zachary J. , Croat S. J. , Struffert Samantha 
Published: January 2024

AbstractFarmland within the Williston Basin of North Dakota was the site of the largest terrestrial oil spill to date in the United States in 2013. Over 3200 m3 of oil was released into the topsoil and subsoil, creating a risk to soil, water, and air resources. The purpose of this document is to provide a summary of results from a 7‐year project investigating the impacts of how thermal desorption (TD), the method used to remediate topsoil and subsoil, impacted contaminant reduction, soil function, and plant productivity simultaneously with site remediation. Soil disturbance and TD decreased soil organic matter and microbial communities, resulting in decreased soil function and plant production. However, TD did not reduce soil microbial recovery 4 years after treatment. Blending TD‐treated soil with uncontaminated topsoil appeared to minimize these negative effects and promote recovery of soil function. These findings provided critical information to stakeholders in the understanding of soil remediation and reclamation in this region.
Associations between a technical assistance model to build school organizational capacity and improvements in student perceptions of school climate
Authors: Ryberg Renee , Her Sarah , Temkin Deborah , Rodriguez Yosmary , Kelley Claire 
Published: January 2024

AbstractOrganizational capacity building—the process of developing leadership, collecting and analyzing data, building buy‐in, and implementing programming—is foundational to effectively changing schools, and frequently relies on technical assistance. This study employed a quasi‐experimental, repeated measured design to evaluate the role of technical assistance provided through Safe School Certification model in improving school climate. Schools worked through an eight‐element framework, using data from a sample of six middle and high schools in Washington, D.C. that completed data collection in all years of the evaluation. Students in schools receiving technical assistance for implementing the SSC Framework had more positive changes in perceptions of school climate than students in schools that did not receive support, but those differences were small. The results from this study offer limited evidence that providing schools with technical assistance to improve organizational capacity is associated with more positive student perceptions of school climate.
Direct N‐Alkylation of Amines with Alcohols Catalyzed by N‐Heterocyclic Carbene Cobalt‐Pincer Catalyst under Mild Conditions
Authors: Liu Xin , Ge Yilei , Yang Yang , Zhang Minghe , Yang Siqi , Lan Xiaobing 
Published: January 2024

AbstractAlcohols are widely available and can be derived from renewable resources. Catalytic alcohol amination for N‐alky amine synthesis using the borrowing hydrogen strategy is an environmentally benign and prominent sustainable method, which produces water as the sole byproduct. However, expensive noble metals are generally employed for this transformation, while the nonprecious metal‐based catalysts were also known for this reaction and have attracted considerable attention recently. Herein, an efficient N‐alkylation of amines with alcohols using base‐metal cobalt catalysts is reported. This reaction is catalyzed by an N‐heterocyclic carbene cobalt‐pincer catalyst and the reaction operates simply and under mild conditions. Various alcohol and aniline substrates and functional groups including nitrile, ether, thioether and alkene could be well tolerated. Moreover, experimental studies and DFT calculations were also performed to illustrate the reaction mechanism. Our results suggest that the N‐alkylation reaction proceeds via a hydrogen autotransfer mechanism.
Application of Wavelet Methods in Computational Physics
Authors: Wang Jizeng , Liu Xiaojing , Zhou Youhe 
Published: January 2024

AbstractThe quantitative study of many physical problems ultimately boils down to solving various partial differential equations (PDEs). Wavelet analysis, known as the “mathematical microscope”, has been hailed for its excellent Multiresolution Analysis (MRA) capabilities and its basis functions that possess various desirable mathematical qualities such as orthogonality, compact support, low‐pass filtering, and interpolation. These properties make wavelets a powerful tool for efficiently solving these PDEs. Over the past 30 years, numerical methods such as wavelet Galerkin methods, wavelet collocation methods, wavelet finite element methods, and wavelet integral collocation methods have been proposed and successfully applied in the quantitative analysis of various physical problems. This article will start from the fundamental theory of wavelet MRA and provide a brief summary of the advantages and limitations of various numerical methods based on wavelet bases. The objective of this article is to assist researchers in choosing the appropriate numerical methodologies for their particular physical issues. Furthermore, it will explore prospective advancements in wavelet‐based techniques, offering valuable insights for researchers committed to enhancing wavelet numerical methods in the field of computational physics.