bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of supply chains for the sustainability transformation of global food systems: A large‐scale, systematic review of food cold chains
Authors: Trotter Philipp A. , Becker Tristan , Renaldi Renaldi , Wang Xinfang , Khosla Radhika , Walther Grit 
Published: October 2023

AbstractGlobal food systems need an urgent transformation to be compatible with sustainable development. While much of the recent academic discussion has focused on food production and consumption, food supply chains have received considerably less attention. Here, we conduct a large‐scale, systematic literature review of 48,014 academic articles to assess the links between the food cold chain literature and sustainable development. We find a multitude of deep links between food cooling and the Sustainable Development Goals (SDGs), but also identify underexplored areas of sustainable food cooling research regarding its (1) goals, (2) analytical depth, and (3) context specificity: There is a limited understanding how several relevant synergies between SDGs can be captured, how to best design sustainable food cold chains across multiple value chain stages, and how to scale sustainable cold chains in low‐income and lower‐middle‐income country contexts. We recommend to explicitly consider the salient interconnections between SDGs, increase the analytical depth by deploying more system‐level approaches across entire value chains, and focus on localized solutions in contexts where food supply chains are most underdeveloped.
The cognitive appraisal path of stroke knowledge, coping traits, family functioning and stigma among stroke patients: A moderated parallel mediation model
Authors: Liu Heng‐Yu , Liu Qun‐Hong , Li Zhuo‐Ran , Deng Cheng‐Song , Zhang Xiao‐Pei , Wan Li‐Hong 
Published: October 2023

AbstractAimsTo establish a cognitive appraisal path model that examines the impact of stroke knowledge on stigma with the parallel mediating effects of negative and positive coping traits, as well as the moderating effects of family functioning.BackgroundStroke‐related stigma, a ‘mixture’ of negative emotions involving internal criticism and external judgement, has been shown to impair patients' health outcomes. However, the specific factors underlying cognitive appraisals and their pathways remain unknown.DesignA cross‐sectional design.MethodsThe cross‐sectional sample was from two stroke centres in China. Questionnaires were administered to collect sociodemographic data, stroke knowledge, coping traits, family functioning and stigma. Hierarchical regression models and the moderated parallel mediation model were constructed to analyse influencing pathways. The study adhered to the strengthening the reporting of observational studies in epidemiology guideline.ResultsAll 144 samples reported stigma symptoms with a moderate‐to‐high standardising score. The best hierarchical regression model explains 55.5% of the variance in stigma. The parallel mediation model indicated that negative and positive coping traits co‐mediating the association of stroke knowledge and stigma. After adding the family functioning as a moderator, the moderated parallel mediation model was confirmed with adequate fit indices.ConclusionAmong the cognitive appraisal factors affecting stroke‐related stigma, stroke knowledge reduces stigma by modifying coping traits, while poor family functioning may serve as an opposing moderator. Notably, when family support is insufficient, enhanced stroke knowledge might paradoxically exacerbate the stigma.Relevance to Clinical PracticeThis study contributes knowledge on transforming health education and emphasises the pivotal roles of clinical nursing practitioners. In similar global contexts, the study highlights integrating health education, psychological counselling and family support to advance systematic nursing practices.Patient or Public ContributionNone.
Age‐ and caste‐independent piRNAs in the germline and miRNA profiles linked to caste and fecundity in the ant Temnothorax rugatulus
Authors: Seistrup Ann‐Sophie , Choppin Marina , Govind Shamitha , Feldmeyer Barbara , Kever Marion , Karaulanov Emil , Séguret Alice , Karunanithi Sivarajan , Almeida Miguel V. , Ketting René F. , Foitzik Susanne 
Published: October 2023

AbstractSocial insects are models for studies of phenotypic plasticity. Ant queens and workers vary in fecundity and lifespan, which are enhanced and extended in queens. Yet, the regulatory mechanisms underlying this variation are not well understood. Ant queens live and reproduce for years, so that they need to protect their germline from transposable element (TE) activity, which may be redundant in short‐lived, often sterile workers. We analysed the expression of two protective classes of small RNAs, microRNAs (miRNAs) and Piwi‐interacting RNAs (piRNAs), in various tissues, castes and age classes of the ant Temnothorax rugatulus. In queens, piRNAs were highly abundant in ovaries with TEs being their clear targets, with reduced but still detectable piRNA‐specific ping‐pong signatures in thorax and brains. piRNA pathway activity varied little with age in queens. Moreover, the reduced ovaries of workers also exhibited similar piRNA activity and this not only in young, fertile workers, but also in older foragers with regressed ovaries. Therefore, these ants protect their germline through piRNA activity, regardless of ovarian development, age or caste, even in sterile workers often considered the soma of the superorganism. Our tissue‐specific miRNA analysis detected the expression of 304 miRNAs, of which 105 were expressed in all tissues, 10 enriched in the brain, three in the thorax, whereas 83 were ovarian‐specific. We identified ovarian miRNAs whose expression was related to caste, fecundity and age, and which likely regulate group‐specific gene expression. sRNA shifts in young‐ to middle‐aged queens were minor, suggesting delayed senescence in this reproductive caste.
The QRS frontal plane axis changes during left bundle branch block after transcatheter aortic valve replacement
Authors: Yagel Oren , Belhassen Bernard , Planer David , Amir Offer , Elbaz‐Greener Gabby 
Published: October 2023

AbstractBackground and AimsLeft bundle branch block (LBBB) is common after transcatheter aortic valve replacement (TAVR) and associated with a left or normal QRS axis. We aim to assess the QRS frontal plane axis shift changes during LBBB after TAVR and determine if the risk of procedure‐related high degree atrioventricular block (AVB) is affected by QRS axis shift changes.Methods and ResultsIn a retrospective single‐center study of 720 consecutive patients who underwent TAVR, 141 (19.6%) with normal baseline QRS duration developed a new LBBB after TAVR and constituted the study group. Most patients (59.6%) were females and the mean age of the cohort was 81.2 ± 6 years.ResultsAs compared with the baseline QRS axis before TAVR, the occurrence of LBBB was associated with a leftward QRS axis shift (by 40 ± 28.3°) in 73% of the study patients and a rightward (by 18.6 ± 19.4°) or no change in QRS axis in 25.6% and 1.4% of the study patients, respectively. A left QRS axis (−30°) was observed in 14.9% and 38.3% of the study patients before and after TAVR, respectively. The group of patients exhibiting a rightward or no QRS axis shift had a greater incidence of high degree AVB than the group of patients exhibiting a leftward QRS axis shift (18.4% vs. 6.8%, p = .056).ConclusionAlthough post TAVR‐LBBB is associated with a leftward QRS axis shift in most patients, a non‐negligible proportion of patients (27%) exhibited a rightward or no QRS axis shift. The latter group tend to have a higher risk of developing high degree AVB.
Fatty infiltration of the erector spinae at the upper lumbar spine could be a landmark for low back pain
Authors: Ekşi Murat Şakir , Özcan‐Ekşi Emel Ece 
Published: October 2023

AbstractPurposeIntervertebral disc degeneration (IVDD), Modic changes, and fatty infiltration in the paraspinal muscles are possible causes of low back pain (LBP). Multifidus has been the most commonly blamed paraspinal muscle in the etiology of LBP. However, it contributes to 20% of the extensor moment on the lumbar spine. In the present study, we aimed to identify whether patients with LBP and asymptomatic subjects differed in terms of intervertebral discs, end‐plates, and fatty infiltration in their paraspinal muscles.MethodsConsecutive women and men, who visited the spine outpatient clinics with chronic LBP and had lumbar spine MRI for their LBP without leg pain were included. Asymptomatic subjects without LBP/leg pain for the last year were recruited. Modic changes, IVDD, and fatty infiltration in the paraspinal muscles were evaluated on lumbar spine magnetic resonance imagings of the patients with LBP and age‐, gender‐ and BMI‐matched asymptomatic controls.ResultsLow back pain was closely associated with fatty infiltration in the paraspinal muscles at all lumbar levels whereas it had association with severe IVDD and Modic changes at lower lumbar levels. Multifidus at the lower lumbar levels was the fattiest paraspinal muscle in both asymptomatic subjects and patients with LBP. Patients with LBP had severe fatty infiltration in the erector spinae at the upper lumbar levels.ConclusionSevere IVDD and Modic changes were more common at lower lumbar levels in patients with LBP. Both asymptomatic subjects and those with LBP had fatty multifidus at lower lumbar levels, whereas those with LBP had fatty infiltration in the erector spinae at upper lumbar levels. We suggest that fatty infiltration could have started in the multifidus. The erector spinae had greater contribution to the lumbar extension compared to the multifidus. Thus, LBP could develop when the quality of the erector spinae at the upper lumbar levels impairs due to fatty infiltration.
Stomatal closure prevents xylem transport of green leaf volatiles and impairs their systemic function in plants
Authors: Maleki Feizollah A. , Seidl‐Adams Irmgard , Fahimi Azadeh , Peiffer Michelle L. , Kersch‐Becker Monica F. , Felton Gary W. , Tumlinson James H. 
Published: October 2023

AbstractPlants perceive environmental stresses as whole organisms via distant signals conveying danger messages through their vasculature. In parallel to vascular transport, airborne plant volatile compounds, including green leaf volatiles (GLVs), can bypass the lack of vascular connection. However, some small volatile compounds move through the vasculature; such vascular transport is little known about GLVs. Here we illustrate GLV alcohols as solutes move within xylem vessels in Zea mays. We describe GLV alcohols, including Z‐3‐hexen‐ol and its isomer E‐3‐hexen‐ol, which is not synthesized in maize, moving through the transpiration stream via xylem vessels. Since transpiration is mediated by the stomatal aperture, closing stomata by two independent methods diminishes the transport of GLV alcohol and its isomer. In addition, the lower transport of GLV alcohols impairs their function in inducing terpenoid biosynthesis, suggesting that xylem transport of GLV alcohols plays a significant role in their systemic function. Our study suggests that GLV alcohols, in addition to airborne signals, are transported through xylem vessels. Our findings can be critical in future studies about the perception and function of these compounds in plants.
Idiopathic calcinosis cutis in an infant: The importance of a wait‐and‐see approach
Authors: Stathopoulou Anna , Noguera‐Morel Lucero , Colmenero Isabel , Sirvent‐Cerdá Sara , Torrelo Antonio , Hernández‐Martín Ángela 
Published: October 2023

AbstractA healthy 2‐year‐old girl presented with multiple asymptomatic subcutaneous nodules on both legs. Histologically demonstrated calcium deposition within the dermis and subcutaneous tissue consistent with calcinosis cutis. Laboratory abnormalities, underlying genetic conditions, and potential triggering factors were ruled out. The lesions resolved over an 18‐month period without treatment, emphasizing the importance of the wait‐and‐see approach in idiopathic cases of calcinosis cutis.
Development and empirical test of the research‐informed South African Relationship Functioning Assessment (SARFA)
Authors: Belus Jennifer M. , Hines Abigail C. , Magidson Jessica F. , Iwamoto Derek K. , Rose Alexandra L. , Li Alison , Barnabas Ruanne V. , van Heerden Alastair 
Published: October 2023

AbstractIntimate partners play an important role in chronic diseases. Despite the chronic disease burden in sub‐Saharan Africa, very few culturally relevant quantitative measures of intimate relationship functioning are available. We conducted an empirical investigation evaluating the psychometric properties of the South African Relationship Functioning Assessment (SARFA) assessing healthy relationship functioning in N = 150 community members (50% women; M age = 27.2 years) living in the Vulindlela area of KwaZulu‐Natal, South Africa. Item development was based on prior qualitative research from two South African communities. All assessments were conducted in isiZulu, participants' primary language. An exploratory factor analysis was conducted on the initial 39‐item measure. The best‐fitting model consisted of one factor with 22 items. The SARFA's internal consistency was α = .94. Convergent validity was observed via significant positive associations (all rs ≥ .38, p < .001) between the SARFA's total score and measures of trust, emotional intimacy, constructive communication, sexual satisfaction, and relationship control (women only). Divergent validity was observed for women only. Encouraging initial psychometric properties of a culturally relevant measure of relationship functioning in KwaZulu‐Natal may have relevance to other communities and potential to be used in research involving couples and health in chronic disease‐burdened communities.
Prevalence and incidence of transfusion‐transmissible infections among blood donors in Malawi: A population‐level study
Authors: Singogo Emmanuel , Chagomerana Maganizo , Van Ryn Collin , M'bwana Robert , Likaka Andrew , M'baya Bridon , Puerto‐Meredith Sydney , Chipeta Effie , Mwapasa Victor , Muula Adamson , Reilly Cavan , Hosseinipour Mina C. ,   Malawi BLOODSAFE Program
Published: October 2023

AbstractBackgroundVoluntary non‐remunerated blood donors (VNRBDs) are essential to sustain national blood supplies. Expanding testing capacity for the major transfusion‐transmitted infections (TTI) is crucial to ensure safe blood products. Understanding trends in TTIs can inform prioritisation of resources.MethodsWe conducted a retrospective cohort data analysis of routine blood donation data collected from VNRBDs by the Malawi Blood Transfusion Service from January 2015 to October 2021. Variables included age, occupation; and screening results of TTIs (HIV, Hepatitis B and C, and syphilis). We estimated both prevalence and incidence per person‐year for each TTI using longitudinal and spatial logistic regression models.ResultsOf the 213 626 donors, 204 920 (95.8%) donors were included in the final analysis. Most donors (77.4%) were males, baseline median age was 19.9 (IQR 18.0, 24.1), 70.9% were students, and over 80.0% were single at first donation. Overall TTI prevalence among donors was 10.7%, with HBV having the highest prevalence (3.4%), followed by syphilis (3.3%), then HIV (2.4%) and HCV (2.4%). Incidence per 1000 person‐years for syphilis was 20.1 (19.0, 21.3), HCV was 18.4 (17.3, 19.5), HBV was 13.7 (12.8, 14.7), and HIV was 11.4 (10.6, 12.3). We noted geographical variations with the northern region having lower rates of both prevalence and incidence compared to central and southern regions.ConclusionThe individual TTI prevalence and incidence rates from this study are consistent with Southern African regional estimates. By identifying geographical variations of TTI prevalence and incidence, these findings could potentially inform prioritisation of blood collection efforts to optimise blood collection processes.
Application of a Multidisciplinary Design Process to Assess the Influence of Requirements and Constraints on the Design of Military Engines
Authors: Matuschek Tomasz , Otten Tom , Zenkner Sebastian , Becker Richard-G. , Zamboni Jacopo , Moerland Erwin 
Published: October 2023

Abstract
The design of supersonic military aircraft is a complex multidisciplinary optimization process in which the dependencies and strong interactions between engine and aircraft must be imperatively considered. Applying a fully coupled propulsion–airframe design system is a highly challenging task, since it requires a set of numerically stable analysis tools capable of optimizing multiple design variables simultaneously. To improve computational efficiency, the application of low-fidelity design of experiment (DOE) methods aids in narrowing down the selection of suitable combinations of design parameters. This approach allows the division of the multidisciplinary process into subsystems, each of which can be served by specialized engineers. Interactions between the disciplines are then considered by exchanging DOE-based sensitivities. This paper presents the multidisciplinary design process developed at the German Aerospace Center (DLR)—in which the airframe and propulsion system are designed simultaneously while effectively utilizing DOE-based sensitivities. Guiding the work is an application case on the preliminary design of military engine concepts considering its effects on overall integrated aircraft architecture. The design process is used to investigate the influence of important engine parameters such as overall pressure ratio (OPR), bypass ratio (BPR), and turbine entry temperature (T4) on the design of military aircraft. Furthermore, the impacts of thrust requirements and technological constraints of the engine are analyzed.
Early Postnatal Experience Modifies Activation of the Pituitary Testicular Complex in Male House Mice (Mus Musculus) Exposed to the Odor of Receptive Con- and Heterospecific Females
Authors: Kotenkova E. V. , Kuznezova E. V. , Maltsev A. N. , Ambaryan A. V. 
Published: October 2023

Abstract
For the first time, it was shown that activation of the pituitary–testicular complex in male house mice exposed to the odor of receptive females of their own and closely related species was modified under the influence of early postnatal experience and the maternal environment. We have confirmed associated formation of behavioral and physiological mechanisms of precopulatory isolation in early ontogenesis. The serum levels of free testosterone in males of closely related species M. spicilegus and M. m. wagneri differ, it is significantly lower in mound-building mice. In males fostered by a conspecific female, the level of free testosterone was significantly lower when exposed to a heterospecific female odor in comparison with a conspecific odor. The rearing of M. m. wagneri males by females of a closely related species led to a decrease in the testosterone response caused by exposure to female chemosignals (both con- and heterospecific) and to the absence of differences in the serum level of free testosterone when exposed to the odor of a female of their own or closely related species. These results indicate that the rearing conditions had a significant influence on the formation of hormonal mechanisms of reproductive isolation.
Comparative Pharmacoeconomic Effectiveness of Interleukin-17 Inhibitors for the Treatment of Ankylosing Spondylitis
Authors: Dubinina T. V. , Gaidukova I. Z. , Sableva N. A. , Sapozhnikov K. V. , Sokolova V. D. , Tolkacheva D. G. 
Published: October 2023

Abstract
The objective of this study was to compare the clinical efficacy and cost-effectiveness of IL-17 inhibitors (SEC, IXE, NTK) in the treatment of adult patients with ankylosing spondylitis (AS) in the healthcare system of the Russian Federation. Materials and methods. The study is a sub-analysis of a previously published systematic review and network meta-analysis of the comparative efficacy of biologics in adult patients with AS in the Russian Federation. NNT values were calculated for BASDAI 50 and ASAS 20/40 after 16 weeks of therapy for all studied drugs. CpR was estimated for each biologic after 16 weeks and one year of therapy. Additionally, we carried out an assessment of the financial burden of the most cost-effective strategies for the treatment of AS. The use of NTK is characterized by an average of no more than three patients needed to treat to achieve one ASAS 20/40 or BASDAI 50 response, while on IXE and SEC no more than 4–5 patients need to be treated, depending on the estimated effectiveness criterion. According to CpR estimate, NTK is the most cost-effective IL-17 inhibitor for the treatment of AS, both after 16 weeks and after one year of therapy. The obtained results make it possible to compare the effectiveness of IL-17 inhibitors from a clinical and economic points of view and can be used both in decision making on treatment strategies for individual patients and at the population level when deciding on the reimbursement of drugs.
Deep geometric learning for intracranial aneurysm detection: towards expert rater performance
Authors: Bizjak Žiga , Choi June Ho , Park Wonhyoung , Pernuš Franjo , Špiclin Žiga 
Published: October 2023

BackgroundEarly detection of intracranial aneurysms (IAs) is crucial for patient outcomes. Typically identified on angiographic scans such as CT angiography (CTA) or MR angiography (MRA), the sensitivity of experts in studies on small IAs (diameter <3 mm) was moderate (64–74.1% for CTAs and 70–92.8% for MRAs), and these figures could be lower in a routine clinical setting. Recent research shows that the expert level of sensitivity might be achieved using deep learning approaches.MethodsA large multisite dataset including 1054 MRA and 2174 CTA scans with expert IA annotations was collected. A novel modality-agnostic two-step IA detection approach was proposed. The first step used nnU-Net for segmenting vascular structures, with model training performed separately for each modality. In the second step, segmentations were converted to vascular surface that was parcellated by sampling point clouds and, using a PointNet++ model, each point was labeled as an aneurysm or vessel class.ResultsQuantitative validation of the test data from different sites than the training data showed that the proposed approach achieved pooled sensitivity of 85% and 90% on 157 MRA scans and 1338 CTA scans, respectively, while the sensitivity for small IAs was 72% and 83%, respectively. The corresponding number of false findings per image was low at 1.54 and 1.57, and 0.4 and 0.83 on healthy subject data.ConclusionsThe proposed approach achieved a state-of-the-art balance between the sensitivity and the number of false findings, matched the expert-level sensitivity to small (and other) IAs on external data, and therefore seems fit for computer-assisted detection of IAs in a clinical setting.