bluuebunny/crossref_metadata_2025_split huggingface dataset:
What do readers want? Results of an online survey to involve readers in updating the seventh edition of the Manual of dietetic practice
Authors: Wedlake Linda , Mellor Duane , Marriott Tom , Maslin Kate , Frost Gary , Hickson Mary 
Published: October 2023

AbstractBackgroundThe Manual of dietetic practice (‘Manual’) is the core textbook for qualified and student dietitians. A survey was conducted to explore views on the scope, content and presentation of the Manual to inform the forthcoming edition.MethodsThe survey comprised of questions on demographics, structure, content, access (print/digital), missing topics, strengths and weaknesses. It was distributed to members of the British Dietetic Association (BDA) and other relevant groups in August 2022. Responses are presented as frequencies and free text as themes.ResultsOf 1179 responses, 91% were from professionals, of whom 72% were registered dietitians with a mean of 12.7 years (range: 1–44) in practice: 60% worked in the United Kingdom with 52% based in a clinical setting. The printed version was preferred: 59% professionals, 60% students, 94% professionals and 88% students were satisfied with the structure; however, 26% professionals and 22% students identified content that was lacking or outdated, including mental health and sustainability. The strengths were its comprehensive coverage and respected contributing authors. Weaknesses included the cost, size, lack of visual aids and currency. Professionals indicated the seventh edition should focus on more practical information required for clinical practice, whereas students wanted more emphasis on summarised information and visual formats.ConclusionsThe survey proved a valuable method to engage with the readership to ensure the next edition reflected their requirements. Although nearly all respondents were satisfied with the scope and content, the results highlighted those topics lacking and/or outdated. Results also showed that the next edition should focus on practical information required for clinical practice, with more summarised and visual formats.
Field‐dependent abundances of hydride molecular ions in atom probe tomography of III‐N semiconductors
Authors: Diagne Aissatou , Garcia Luis Gonzalez , Ndiaye Samba , Gogneau Noëlle , Vrellou Maria , Houard Jonathan , Rigutti Lorenzo 
Published: October 2023

AbstractWe investigate the microscopic behaviour of hydrogen‐containing species formed on the surface of III‐N semiconductor samples by the residual hydrogen in the analysis chamber in laser‐assisted atom probe tomography (APT). We analysed AlGaN/GaN heterostructures containing alternate layers with a thickness of about 20 nm. The formation of H‐containing species occurs at field strengths between 22 and 26 V/nm and is independent of the analysed samples. The 3D APT reconstruction makes it possible to map the evolution of the surface behaviour of these species issued by chemical reactions. The results highlight the strong dependence of the relative abundances of hydrides on the surface field during evaporation. The relative abundances of the hydrides decrease when the surface field increases due to the evolution of the tip shape or the different evaporation behaviour of the different layers.
Association of the Japanese herbal kampo medicine kakkonto with antibiotic use and surgical drainage for noninfectious mastitis: A nationwide database study
Authors: Endo Masayuki , Konishi Takaaki , Yamana Hayato , Jo Taisuke , Ishikawa Tomoki , Yasunaga Hideo 
Published: October 2023

AbstractAimKakkonto, a Japanese herbal kampo medicine, is empirically prescribed to improve milk stasis and ameliorate breast inflammation in patients with noninfectious mastitis. We investigated whether early use of kakkonto is associated with a reduction in antibiotic use and surgical drainage in patients with noninfectious mastitis.MethodsWe identified 34 074 patients with an initial diagnosis of noninfectious mastitis within 1 year of childbirth between April 2012 and December 2022 using the nationwide administrative JMDC Claims Database. Patients were divided into the kakkonto (n = 9593) and control (n = 9648) groups if they received and did not receive kakkonto on the day of the initial diagnosis of noninfectious mastitis, respectively. Antibiotic administration and surgical drainage within 30 days after the initial diagnosis of noninfectious mastitis in the two groups were compared using propensity score‐stabilized inverse probability of treatment weighting analysis.ResultsThe frequency of antibiotic administration within 30 days after the initial diagnosis of noninfectious mastitis was significantly lower in the kakkonto group than in the control group (10% vs. 12%; odds ratio, 0.88 [95% confidence interval, 0.80–0.96]). The frequency of antibiotic administration during 1–3 and 4–7 days after the initial diagnosis were also significantly lower in the kakkonto group than in the control group. The frequency of surgical drainage did not differ significantly between the two groups.ConclusionsKakkonto was associated with reduced administration of antibiotics for noninfectious mastitis, making it a potential treatment option for relieving breast inflammation and promoting antimicrobial stewardship.
Temporal trends and regional variation of heart transplantation in children with intellectual and developmental disabilities
Authors: Adebiyi Ebenezer , Jennifer Christine Munoz Pareja 
Published: October 2023

AbstractBackgroundHistorically, intellectual and developmental disability (IDD) has been considered an important factor in choosing potential recipients of organ transplants among many transplant centers. This study evaluated the temporal changes at the national and regional levels in the proportion of heart transplantation in children with IDD.MethodsChildren younger than 19 years in the United Network for Organ Sharing (UNOS) database who received heart transplants from 2010 to 2021 were included in this study. The patients were grouped into only definitive intellectual disability, both definitive intellectual and motor disability, only definitive motor disability, and no developmental disability. Multinomial logistic regressions were used to examine the proportion of heart transplants in each category for the whole cohort and each geographic transplant region.ResultsThere were 4273 pediatric heart transplant recipients included in the study. From 2010 to 2021, the percentages of pediatric heart transplants increased from 3.8% (95% CI, 0.01–0.05) to 5.8% (95% CI, 0.03–0.08) in children with only definitive intellectual disability (OR 0.07; 95% CI, 0.02–0.1, ptrend < .002), from 3.4% (95% CI, 0.01–0.05) to 6.6% (95% CI, 0.04–0.09) in children with both definitive intellectual disability and motor disability (OR 0.09; 95% CI, 0.05–0.13, ptrend < .001), and from 5.2% (95% CI, 0.02–0.07) to 8.3% (95% CI, 0.05–0.1) in children with only definitive motor disability (OR 0.06; 95% CI, 0.02–0.09, ptrend < .002). There were several regional differences in the proportion of children with intellectual and developmental disabilities who received heart transplants.ConclusionThere is increasing inclusion of children diagnosed with intellectual and developmental disabilities in heart transplantation. A review of the current allocation policies may address the marked geographic variations found in this study.
Symmetries of the DΔmKP hierarchy and their continuum limits
Authors: Liu Jin , Zhang Da‐jun , Zhao Xuehui 
Published: October 2023

AbstractIn the recent paper [Stud. App. Math. 147 (2021), 752], squared eigenfunction symmetry constraint of the differential‐difference modified Kadomtsev–Petviashvili (DΔmKP) hierarchy converts the DΔmKP system to the relativistic Toda spectral problem and its hierarchy. In this paper, we introduce a new formulation of independent variables in the squared eigenfunction symmetry constraint, under which the DΔmKP system gives rise to the discrete spectral problem and a hierarchy of the differential‐difference derivative nonlinear Schrödinger equation of the Chen–Lee–Liu type. In addition, by introducing nonisospectral flows, two sets of symmetries of the DΔmKP hierarchy and their algebraic structure are obtained. We then present a unified continuum limit scheme, by which we achieve the correspondence of the mKP and the DΔmKP hierarchies and their integrable structures.
Religious liberties or reading rainbows? The partisan implications of religious liberties frames in education attitudes
Authors: Walker Brooklyn , Haider‐Markel Donald P. 
Published: October 2023

AbstractObjectiveMany state legislatures have moved to restrict LGBT students’ rights, and the Supreme Court has veered toward greater protection of religious free exercise protection over LGBT nondiscrimination policies. Some studies have found that rights framings are associated with heightened affective and attitudinal polarization, while others have argued that rights framings lead to greater tolerance. Do religious liberties frames affect policy attitudes or group affect? And are some groups’ use of religious liberties frames more persuasive?MethodsWe utilize data from a survey that experimentally varies candidate statements on inclusion of LGBT issues in schools using a religious liberties frame and by the group asserting religious liberties. We use the experiment to document the extent to which religious liberties framings shift support for restriction of LGBT rights in schools and affect toward religious and LGBT Americans.ResultsOur analysis suggests there are few direct effects, but that responses to religious liberties frames reflect debates within the parties about morality, social group conflict, and civic nationalism.ConclusionOur results add to the growing literature on religious liberty, and we argue that there is a need to understand why religious liberties frames produce effects in some circumstances but not in others.
An open‐source metadataset of running European mid‐ and long‐term agricultural field experiments
Authors: Blanchy Guillaume , D'Hose Tommy , Donmez Cenk , Hoffmann Carsten , Makoschitz Lisa , Murugan Rajasekaran , O'Sullivan Lilian , Sandén Taru , Spiegel Heide , Svoboda Nikolai , Zechmeister‐Boltenstern Sophie , Klumpp Katja 
Published: October 2023

AbstractMid‐term (MTEs, 5–20 years) and long‐term (LTEs, 20+ years) field experiments are key sources of information to design future climate‐smart agriculture. Within the European Joint Program SOIL (EJP SOIL), we built the EJP SOIL‐MTE/LTE metadataset that contains metadata from 240 MTEs/LTEs across Europe. Metadata collected included precise descriptions of the treatments (combination of factors such as tillage, crop type/rotation, amendments/fertilizers, grazing and pest/weed management), soil and crop measurements and pedo‐climatic information. Using different figures and dashboards, an overview of those MTEs/LTEs is presented and specific research themes (tillage systems, residue management, amendment type and cover crops) are further analysed within their pedo‐climatic context. An interactive web portal developed in collaboration with the BonaRes project (https://lte.bonares.de), enables users to explore the metadataset and find relevant MTEs/LTEs for specific combinations of practices (e.g. all MTEs/LTEs that investigate cover crops on a Cambisol in no‐tillage system). Finally, a SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis of the metadataset was carried out to highlight the potential contribution of MTEs/LTEs to a harmonized European soil observation and monitoring approach. We propose that the metadataset could be elaborated with metadata from other existing MTEs/LTEs in Europe or even worldwide.
Protein kinase SnRK2.4 is a key regulator of aquaporins and root hydraulics in Arabidopsis
Authors: Shahzad Zaigham , Tournaire‐Roux Colette , Canut Matthieu , Adamo Mattia , Roeder Jan , Verdoucq Lionel , Martinière Alexandre , Amtmann Anna , Santoni Véronique , Grill Erwin , Loudet Olivier , Maurel Christophe 
Published: October 2023

SUMMARYSoil water uptake by roots is a key component of plant water homeostasis contributing to plant growth and survival under ever‐changing environmental conditions. The water transport capacity of roots (root hydraulic conductivity; Lpr) is mostly contributed by finely regulated Plasma membrane Intrinsic Protein (PIP) aquaporins. In this study, we used natural variation of Arabidopsis for the identification of quantitative trait loci (QTLs) contributing to Lpr. Using recombinant lines from a biparental cross (Cvi‐0 x Col‐0), we show that the gene encoding class 2 Sucrose‐Non‐Fermenting Protein kinase 2.4 (SnRK2.4) in Col‐0 contributes to >30% of Lpr by enhancing aquaporin‐dependent water transport. At variance with the inactive and possibly unstable Cvi‐0 SnRK2.4 form, the Col‐0 form interacts with and phosphorylates the prototypal PIP2;1 aquaporin at Ser121 and stimulates its water transport activity upon coexpression in Xenopus oocytes and yeast cells. Activation of PIP2;1 by Col‐0 SnRK2.4 in yeast also requires its protein kinase activity and can be counteracted by clade A Protein Phosphatases 2C. SnRK2.4 shows all hallmarks to be part of core abscisic acid (ABA) signaling modules. Yet, long‐term (>3 h) inhibition of Lpr by ABA possibly involves a SnRK2.4‐independent inhibition of PIP2;1. SnRK2.4 also promotes stomatal aperture and ABA‐induced inhibition of primary root growth. The study identifies a key component of Lpr and sheds new light on the functional overlap and specificity of SnRK2.4 with respect to other ABA‐dependent or independent SnRK2s.
A Screw Approach to Vibration Analysis of Beam Structures With Nonstandard Conditions
Authors: Lee Yeong Geol , Lee Duck-Hee 
Published: October 2023

Abstract
A major advantage of the screw theory is that translations and rotations are treated simultaneously, which can provide greater insight into the vibration phenomena, such as vibration centers and axes. The present study describes how these concepts are extended into beam theory. The stiffness matrix of a beam was derived by incorporating different types of vibrations, such as extension, compression, torsion, and bending, at the same time, which was then used to obtain the equations of motion, including nonstandard forms of boundary conditions. We then presented an analytical method to solve these equations by focusing on two distinct examples, namely the cantilever and robot link. In the first numerical example, the mode shapes of the beam could be regarded as rotations about the vibration centers or axes of the rigid bodies in a discrete system. In the second example, the analytical solutions of mode shapes and natural frequencies of a robot link, for which the revolute joints at both sides are not parallel, were presented to demonstrate the utility of the screw theory. We demonstrated that the screw approach could accurately describe the vibrations of both discrete and continuous systems and that the geometric meaning of the vibration modes of discrete systems can be extended into continuous systems.
The Role of Diffusive Mixing in Current and Future Aviation Fuels at Relevant Operating Conditions
Authors: Di Sabatino Francesco , Wan Kevin , Manin Julien , Capil Tyler , Hicks Yolanda , Gander Alex , Crua Cyril 
Published: October 2023

Abstract
With aviation's dependence on the high volumetric energy density offered by liquid fuels, Sustainable Aviation Fuels (SAFs) could offer the fastest path toward the decarbonization of aircrafts. However, the chemical properties of SAFs present new challenges, and research is needed to better understand their injection, combustion, and emission processes. While efforts such as the United States National Jet Fuel Combustion Program (NJFCP) that investigated several aspects in detail, certain processes were unfortunately beyond the reach of this program. One of them in particular is about droplet evaporation at relevant pressures and temperatures, and this represents the focus of the present paper. To address this gap, we characterized the evaporation and mixing of spray droplets injected into well-controlled thermodynamic environments at conditions relevant to modern and next-generation aero-engine combustors. We tested three fuels from the NJFCP, namely, an average Jet A fuel (A-2), an alcohol-to-jet fuel containing highly branched dodecane and hexadecane type components (C-1), and a blend made of 40% C-1 and 60% isoparaffins ranging from 9 to 12 carbon atoms (C-4). We also tested a single component normal alkane: n-dodecane, as well as an advanced bioderived cyclo-alkane fuel: bicyclohexyl. The time evolution of fuel droplets was monitored using high-speed long-distance microscopy in a specific configuration that enabled sharp images to be acquired at these extreme conditions. The collected images were processed using a purposely developed and trained machine learning (ML) algorithm to detect and characterize the droplets' evaporation regime. The results revealed different evaporation regimes, such as classical and diffusive. In agreement with previous studies, evaporation regimes appear to be controlled by ambient pressure, temperature, and fuel type. The measurements demonstrate that diffusive evaporation is relevant at high-pressure conditions, such as takeoff combustor pressures for modern commercial aircraft engines. However, classical evaporation mostly controls mixing at lower pressure, such as cruise altitude conditions. The ML analysis emphasized that multiple evaporation regimes co-existed at the same operating condition and no significant relationship was found between droplet size and evaporation regime. The findings of this work constitute a database for validating spray and droplet models that are necessary for implementing lower emissions fuels in aero-engines.
A Second-Order Scheme for the Generalized Time-Fractional Burgers' Equation
Authors: Chawla Reetika , Kumar Devendra , Singh Satpal 
Published: October 2023

Abstract
A second-order numerical scheme is proposed to solve the generalized time-fractional Burgers' equation. The time-fractional derivative is considered in the Caputo sense. First, the quasi-linearization process is used to linearize the time-fractional Burgers' equation, which gives a sequence of linear partial differential equations (PDEs). The Crank–Nicolson scheme is used to discretize the sequence of PDEs in the temporal direction, followed by the central difference formulae for both the first and second-order spatial derivatives. The established error bounds (in the L2− norm) obtained through the meticulous theoretical analysis show that the method is second-order convergent in space and time. The technique is also shown to be conditionally stable. Some numerical experiments are presented to confirm the theoretical results.
Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates ofAcinetobacter baumannii
Authors: Moussa Samir H. , Shapiro Adam B. , McLeod Sarah M. , Iyer Ramkumar , Carter Nicole M. , Tsai Yu-Kuo , Siu L. Kristopher , Miller Alita A. 
Published: October 2023

ABSTRACTAcinetobacter baumannii-calcoaceticuscomplex (ABC) causes severe infections that are difficult to treat due to pre-existing antibiotic resistance. Sulbactam-durlobactam (SUL-DUR) is a targeted β-lactam/β-lactamase inhibitor combination antibiotic designed to treat serious infections caused byAcinetobacter, including multidrug- and carbapenem-resistant strains. In a recent global surveillance study of 5,032 ABC clinical isolates collected from 2016 to 2021, less than 2% of ABC isolates had SUL-DUR MIC values >4 µg/mL. Molecular characterization of these isolates confirmed the primary drivers of resistance are metallo-β-lactamases or penicillin-binding protein 3 (PBP3) mutations, as previously described. In addition, this study shows that certain common PBP3 variants, such as A515V, are insufficient to confer sulbactam resistance and that the efflux of durlobactam by AdeIJK is likely to play a role in a subset of strains.
Could an optimized joint pharmacokinetic/pharmacodynamic target attainment of continuous infusion ceftazidime-avibactam be a way to avoid the need for combo therapy in the targeted treatment of deep-seated DTR Gram-negative infections?
Authors: Gatti Milo , Rinaldi Matteo , Bonazzetti Cecilia , Gaibani Paolo , Giannella Maddalena , Viale Pierluigi , Pea Federico 
Published: October 2023

ABSTRACT

The objective of this study was to assess the relationship between joint pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ceftazidime-avibactam and the microbiological outcome of documented difficult-to-treat resistant (DTR) Gram-negative infections. A 2-year retrospective cohort study was performed in patients receiving CI ceftazidime-avibactam mono- or combo therapy for documented DTR Gram-negative infections and undergoing therapeutic drug monitoring of both ceftazidime and avibactam. The free fractions of steady-state concentrations (
f
C
ss
) of ceftazidime and avibactam were calculated. The joint PK/PD target was considered optimal when both the
f
C
ss
/MIC ratio for ceftazidime ≥4 (equivalent to 100%
f
T
>4xMIC
) and the
f
C
ss
/C
T
ratio for avibactam >1 (equivalent to 100%
f
T >C
T
of 4.0 mg/L) were simultaneously achieved (quasi-optimal if only one of the two and suboptimal if neither of the two was achieved). Multivariate logistic regression analysis was applied for testing potential variables associated with microbiological failure. Fifty-eight patients were treated with CI ceftazidime-avibactam mono- (36) or combo therapy (22) for documented DTR Gram-negative infections [74.2% for primary or secondary bloodstream infections (BSIs)]. Combo therapy was administered more frequently to intensive care unit (ICU) patients (
P
= 0.023) or for pneumonia (
P
= 0.001) and less frequently for intra-abdominal infections and BSIs (
P
= 0.04). Microbiological failure occurred in five cases (8.6%, three in mono- and two in combo therapy). In the multivariate analysis, the suboptimal/quasi-optimal joint PK/PD target emerged as the only independent predictor of microbiological failure (odds ratio [OR] 11.11; 95% confidence interval [CI] 1.31–93.98;
P
= 0.023), whereas monotherapy was not (
P
= 0.99). Optimized joint PK/PD target attainment of CI ceftazidime-avibactam monotherapy could represent a way forward for allowing microbiological eradication of DTR Gram-negative infections and could render unnecessary combo therapy.