bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNAI1 as a Biomarker for Prognostic Prediction and Targeted Therapy in Lung Squamous Cell Carcinoma
Authors: Li Beibei , Li Rongkai 
Published: January 2024

Abstract

Background
This study investigates the role and potential molecular mechanisms of the SNAI1 gene in lung squamous cell carcinoma (LUSC) and its application in molecular targeted therapy.
Methods
Bioinformatics analysis, including TCGA, TPA, GSEA and CELLMINER analysis, was conducted to analyze the expression levels of the SNAI1 gene in normal and tumor tissues, their correlation with clinical outcomes, and potential targeted drugs.
Results
In normal human tissues, SNAI1 was significantly highly expressed in lung tissues compared to other tissues. However, in LUSC, its expression was significantly downregulated. High expression of SNAI1 mRNA was associated with poor overall survival (OS) and disease-free survival (DFS). The expression level of SNAI1 mRNA was also associated with age, tumor size, lymph node metastasis, and distant metastasis in LUSC patients. A nomogram was constructed to predict the survival of LUSC patients. Furthermore, high expression of the SNAI1 protein in LUSC was associated with poor prognosis. The 5-year survival rate was 37% in the high expression group and 59% in the low expression group. The main subcellular localization of SNAI1 protein in LUSC tissue cells was the nucleus, but strong protein expression also led to its localization in the cytoplasm and membrane. Gene set enrichment analysis (GSEA) revealed a relevance between Snai1 and TP53 signaling pathway in LUSC. SNAI1 can interact with TP53 and HDAC. By utilizing the CELLMINER platform, a wide range of compounds that could potentially target SNAI1, including mTOR, were explored. Therefore, potential targeted drugs for SNAI1 include Epigenetic Modifications inhibitors and mTOR. Studies have shown that these targeted SNAI1 agents hold promise for the treatment of LUSC.
Conclusion
High expression of the SNAI1 gene is significantly associated with poor OS and DFS outcomes in LUSC patients. SNAI1 serves as an independent prognostic factor for LUSC and can be used as a biomarker for prognostic prediction. SNAI1 holds promise for the treatment of LUSC.
Comparison of Quantitative High-definition Microvessel Imaging and Shear Wave Elastography in Preoperative Prediction of Axillary Lymph Node Breast Cancer Metastasis
Authors: Sotoudehnia Setayesh , Sabeti Soroosh , Rosen David , Fazzio Robert , Larson Nicholas B. , Fatemi Mostafa , Alizad Azra 
Published: January 2024

Abstract

Background
Accurate assessment of axillary lymph nodes (ALNs) is a critical step for timely diagnosis of metastasis and proper subsequent intervention in breast cancer patients. Herein, we compare the diagnostic utility of quantitative high-definition microvasculature imaging (qHDMI), shear wave elastography (SWE) and their combination for differentiation of metastatic ALNs from reactive.
Methods
A total of 85 female patients with suspicious ALNs recommended for fine needle aspiration biopsy (FNAB) were included in the study, and the pathology results were used as the gold standard for labeling the status of each ALN. Three SWE metrics and ten qHDMI-derived biomarkers were used in our analyses. Additionally, age, as well as clinical ultrasound features such as nodal size and cortical thickness were included as clinical factors. The Wilcoxon rank-sum test was utilized to analyze distributional differences in biomarkers between metastatic and reactive ALNs. Multiple elastic-net logistic regression models were developed based on varying combinations of clinical, qHDMI, and SWE feature sets. A 70%/30% train/test split was adopted, and ROC curve analyses were performed to evaluate and compare classification performance. Moreover, distributional differences in qHDMI and SWE biomarkers between ALNs corresponding to breast cancer immunohistochemical subtypes luminal A and B were investigated.
Results
Of the total of 85 ALNs included in the analysis, 42 were metastatic. Statistically significant (p-value < 0.05) differences were observed in all but one of the qHDMI biomarkers, as well as all the SWE metrics. Test-set discrimination defined by area under ROC curve (AUC) was low for the model using only clinical features (0.62; 95% CI = [0.39,0.84]), with higher performance observed for models using SWE only (0.93; [0.82,1.00]), qHDMI only (0.97; [0.91,1.00]), qHDMI-SWE (0.97; [0.92,1.00]), and qHDMI-SWE plus clinical biomarkers (0.98; [0.94,1.00]). No statistically significant improvements were seen in the combined SWE-qHDMI and SWE-qHDMI-C classification models relative to the qHDMI-only model, although power for comparison was limited. Four qHDMI biomarkers and two SWE measures exhibited statistically significant distributions among breast cancer luminal A and B subtypes.
Conclusions
qHDMI classification model was able to separate metastatic from reactive ALNs with high accuracy. qHDMI, SWE, and the combined models had improved classification performance over the baseline Clinical model. qHDMI biomarkers can be valuable in determining the malignancy status of suspicious ALNs, providing helpful information regarding breast cancer prognosis.
Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective study
Authors: Iwanaga Haruna , Fujita Naotoshi , Abe Shinji , Naganawa Shinji , Kato Katsuhiko 
Published: January 2024

Abstract

Objective
Radioiodine (I-131) therapy for hyperthyroidism is a well-established and safe treatment option. This study aimed to investigate the relationship between the computed tomography (CT) value and the function and volume of the thyroid gland by identifying the factors that induce changes in the CT value of patients with hyperthyroidism.
Methods
This retrospective study evaluated 42 patients with Graves' disease and 10 patients with Plummer disease. To obtain the mean CT value and volume of the thyroid gland, the entire thyroid gland was set as the region of interest. A test dose of 3.7 MBq I-131 was administered before initiating I-131 therapy, and the radioiodine uptake (RIU) rate was assessed after 3, 24, 96, and 168 h. An approximate curve was plotted based on the RIU values obtained, and the effective half-life (EHL) was calculated. The correlation between the mean CT value and the volume of the thyroid gland, 24-h RIU, EHL, and the free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels was evaluated.
Results
CT value exhibited a significant positive correlation with EHL (r = 0.69, p < 0.0001) and a weak negative correlation with the TRAb in patients with Graves' disease (r = −0.36, p < 0.05). CT value also exhibited a significant positive correlation with EHL in patients with Plummer disease (r = 0.73, p < 0.05). However, it did not display any correlation with the remaining parameters.
Conclusion
The CT value is significantly correlated with EHL and TRAb levels, suggesting that it reflects thyroid function and is mainly related to the factors associated with iodine discharge.
Predictive value of combined triglyceride-glucose index and glycated hemoglobin for long-term cardiovascular outcomes in stable coronary artery disease
Authors: Liu Ru , Zhang Haonan , Wang Qizhe , Xu Yaxin , Dai Yuxiang , Jiang Sunfang , Jiang Hong , Liu Ming 
Published: January 2024

Abstract
Background: Insulin resistance (IR) affects prognosis in stable coronary artery disease (SCAD). While triglyceride-glucose (TyG) index assesses IR, glycated hemoglobin (HbA1c) provides long-term glycemic level information. However, the combined predictive value of TyG index and HbA1c is unclear.
Methods: This retrospective cohort study included 944 SCAD patients who underwent percutaneous coronary intervention (PCI). Major adverse cardiovascular events (MACE) were followed up for 31 months. Receiver operating characteristic (ROC) curves assessed the predictive ability of TyG index, HbA1c and their combination. Patients were further grouped based on the optimal cutoff value of the TyG index and clinical abnormal ranges of HbA1c to analyze the impact of different groups.
Results: The TyG index was independently predictive of MACE and repeat revascularization (HR: 1.574, P = 0.021; and HR: 1.379, P = 0.027). Combining TyG index with HbA1c significantly enhanced overall MACE prediction, with the AUC for cardiac death increasing to 0.901 (P = 0.016). The high TyG-low HbA1c group had more than double the cumulative incidence of MACE compared to the low TyG-low HbA1c group (HR: 2.069, P < 0.001), with the high TyG-high HbA1c group showing an even greater risk (HR: 2.463, P < 0.001). Diabetic patients in the high TyG-low HbA1c category had the highest risk increase (HR: 3.375, P = 0.038).
Conclusions: The combined use of TyG and HbA1c improves the predictive ability for MACE in all SCAD patients, with predictive value for chronic outcomes, but not for acute events.
Is Body Mass Index a Risk Factor in Patients Developing Post-ERCP Complications?
Authors: Abulfazli Jamal , Altunpak Burak , Gumusoglu Alpen , Karabulut Mehmet 
Published: January 2024

Abstract
Background and aims
Despite numerous studies on Endoscopic Retrograde Cholangiopancreatography (ERCP) complications, few have explored the BMI-complication relationship. Our study investigates this association to enhance understanding.
Methods
A retrospective analysis of 196 post-ERCP complication cases (January 2018-December 2021) excluded patients under 18, those with upper gastrointestinal surgery, and altered anatomy. Patients were categorized by BMI into normal weight (32.7%, n = 64), overweight (43.4%, n = 85), and obese (23.9%, n = 47) groups (average BMI: 27.45 ± 5.11). Variables included age, sex, BMI, Charlson Comorbidity Index (CCI), anticoagulant use, ERCP indications, procedure type, sequence number, duration, manipulations, stent placement, complications, hospital stay, and mortality.
Results
No statistically significant BMI-related differences emerged in ERCP indications, emergency/elective procedures, post-ERCP complications (pancreatitis, bleeding, perforation), or hospital stay (p > 0.05). The overweight group exhibited a significantly shorter procedure duration (p = 0.001; p < 0.01) and higher CCI score (p = 0.011; p < 0.05).
Conclusions
Our findings suggest no significant correlation between BMI and post-ERCP complications. Notably, ERCP procedures appear safe in overweight and obese patients.
Comparison οf Immune Responses Through Multiparametric T cell Cytokine Expression Profile Between Children With Convalescent COVID-19 Or Multisystem Inflammatory Syndrome
Authors: Filippatos Filippos , Tzanoudaki Marianna , Tatsi Elizabeth-Barbara , Dessypris Nick , Koukou Dimitra-Maria , Georgokosta Chrysa , Syriopoulou Vasiliki , Michos Athanasios 
Published: January 2024

Abstract
The immunological pathways that cause Multisystem Inflammatory Syndrome after SARS-CoV-2 infection in children(MIS-C) remain under investigation. Aim of this study was to prospectively compare T-cell cytokine expression profile in unvaccinated children with acute MIS-C(MIS-C_A) before immunosuppression, convalescent MIS-C(one month after syndrome onset, MIS-C_C), convalescent COVID-19(one month after hospitalization) and healthy, unvaccinated controls. Intracellular expression of IL-4, IL-2, IL-17, IFN-γ, TNF-α and Granzyme B, post SARS-CoV-2-Spike antigenic mix stimulation of T cell subsets was analyzed by 13-colour Flow Cytometry. Twenty children with median age(IQR): 11.5(7.25-14) years were included in the study. From the comparison of the flow cytometry analysis of the 14 markers of MIS-C_A with the other 3 groups(MIS-C_C, post-COVID-19 and controls), significant differences were identified for: 1. CD4+IL-17+/million CD3+: 293.0(256.4-870.9) vs 50.7(8.4-140.5); P-value:0.03, vs 96.7(89.2-135.4); P-value:0.03 and vs 8.7(0.0-82.4); P-value:0.03, respectively, 2. CD8+IL-17+/million CD3+: 335.2(225.8-429.9) vs 78.0(31.9-128.9) vs 84.1(0.0-204.6) vs 33.2(0.0-114.6); P-value:0.05, respectively 3. CD8+IFN-γ+/million CD3+: 162.2(91.6-273.4) vs 41.5(0.0-77.4); P-value:0.03 vs 30.3(0.0-92.8); P-value:0.08, respectively. In children presenting with MIS-C one month after COVID-19 infection, T cells were found to be polarized towards IL-17 and IFN-γ production compared to those with uncomplicated convalescent COVID-19, a finding that could provide possible immunological biomarkers for MIS-C detection.
Prevalence of Poststroke Depression and Associated Factors in Sri Lanka: A Multicenter Study
Authors: Rathnapurahewage Hansanee Dileka Madumali , Kariyawasam Pramudika Nirmani 
Published: January 2024

Abstract
Background: The incidence of stroke and resultant disabilities in low- and middle-income countries emphasizes the importance of investigating consequential manifestations such as poststroke depression (PSD). PSD is a common consequence of stroke and is associated with poor quality of life.The main objective of this study was to determine the incidence of PSD and associated factors.
Methods: A descriptive cross-sectional study was conducted with the participation of 322 stroke survivors attending neurology clinics at three major tertiary care centers in Sri Lanka. The assessment utilized the Sinhala version of the Patient Health Questionnaire (PHQ-9) for depression screening, alongside a pretested interviewer-administered questionnaire to explore associated factors.
Results: The mean age of the participants was 60.82 (11.91) years, and 59.6% were males and 40.4% were females. Predominantly, ischemic strokes were observed in 84.5% of the patients. A notable 71.4% (n=230) incidence of PSD was identified. The sociodemographic parameters (age, sex, education, income) and clinical factors (stroke type, cognitive level, hemiplegia, concurrent noncommunicable diseases) were significantly associated with PSD at a level of p<0.05.
Conclusion/s: Identified factors that are associated with PSD should be further evaluated and addressed by healthcare providers to improve the quality of life of patients.
Exploring Ageism and Aging Anxiety: A Cross-Sectional Study in Egypt
Authors: Abdelkader Alaa S , Elbayar Rana , Ashour Aya Ahmed , Alwerdani Mariam M , Elgabry Abdallah , Hashish Sara , Ashour Ayat 
Published: January 2024

Abstract

Background
Ageism and ageing anxiety are obstacles to health equity in the community. This study aims to assess ageism and ageing anxiety in Egypt and to elaborate on factors associated with ageism among Egyptians.
Method
We conducted a cross-sectional online survey on 359 adult Egyptians using a predesigned questionnaire to assess socio-demographic factors, the Fabroni Scale on Ageism (FSA), the Ageing Anxiety Scale (AAS), one question about contact with older adults and another question about religiosity.
Results
The mean total score of ageism was 72.79 ± 6.3 out of 116 while the mean total score of anxiety of ageing was 54.33 ± 8.83 out of 100. Male gender (B = 1.602, p = 0.024), infrequent contact with older adults (B = 2.158, p = 0.002), aging anxiety (B = 0.172, p = 0.000), and insufficient income (B = 3.103, p = 0.007) were associated with increased ageism scores.
Conclusion
The observed associations between ageism and factors such as male gender, infrequent contact with older adults, insufficient income, and aging anxiety highlights potential need for focused educational initiatives. Implementing comprehensive educational programs that not only inform individuals about the ageing process but also promote positive intergenerational interactions could serve as a promising strategy to combat ageism.
Physiotherapeutic Management of Hand-Foot Syndrome During Chemotherapy: a Case Report Autor para correspondência: Gabrielle Peres Paines
Authors: Paines Gabrielle Peres , Machado Fábio Dotto , Kemerich Jhulie Anne Pinheiro , Pivetta Hedioneia Maria Foletto 
Published: January 2024

Abstract

Objectives To evaluate the management of hand-foot syndrome due to chemotherapy treatment by using physiotherapeutic intervention based on photobiomodulation.Methodology: This is a case report of a female patient who was treated at the Physiotherapy outpatient clinic of a Teaching Hospital at the country side of the State of RS and was diagnosed with Grade III invasive ductal mammary carcinoma in the right breast. Approved by the Federal University of Santa Maria's Ethics and Research Committee, number 48881321.4.0000.5346, Red and infrared LED at 4 J/cm2 were applied to the plantar surfaces of the hands and feet once a week as part of the standard physiotherapeutic treatment, which also included proprioceptive, resistance, and aerobic activities.Results An improvement in skin features was seen right away after the initial application, cell regeneration and epithelial neoformation, peeling on the plantar surface of the hands and feet, a decrease in hyperemia, and a pain-relieving effect. On the palm side of the hands, complete skin peeling, a decrease in edema, hyperemia, and discomfort were seen after the second application. Plantar hyperkeratosis on the foot completely disappeared, and there was a decrease in edema, hyperemia, burning, and pain. Finally, total rejuvenation of the skin on the plantar surface of the palms and soles of the feet was seen, enabling the recovery of previously impossible daily activities. Additionally, it enabled the continuation of chemotherapeutic treatments.Conclusion The hand-foot condition brought on by chemotherapy could be effectively treated with physical therapy and photobiomodulation employing red and infrared LEDs.
Research on the Characteristics and Influencing Factors of Carbon Transfer Based on Value Chain in China
Authors: Dong Xiaocui , Liu Hongguang 
Published: January 2024

Abstract
Carbon emission reduction is an arduous task that the world needs to face and solve at present and in the coming period, and it is also an important goal in the process of China's economic and social development. It is also an important goal in the process of China's economic and social development. The study of carbon transfer based on the value chain is crucial to the realization of carbon emission reduction and the scientific and reasonable distribution of carbon emission reduction responsibilities. Based on the input-output method, this paper uses the value-based carbon emission accounting method to calculate and analyze the carbon emission transfer characteristics of 30 provinces, autonomous regions and cities in China (excluding Tibet, Hong Kong, Macao and Taiwan) in 2012 and 2017. As many indicators of different aspects as possible are selected, and the problem of covariance between indicators is reduced and eliminated through factor analysis, so as to analyze the key factors affecting carbon transfer. It was found that during 2012–2017, China's carbon emissions as a whole showed a transfer from regions with a higher level of economic development to regions with a lower level of economic development, and from the east to the west, with the net transfer out center of gravity shifting significantly to the north and west. The middle region (MR) has always been the region that transfers out the most carbon emissions, but the net transfer growth rate of some provinces in the MR has decreased more with other regions. During this period, the local resource availability, energy consumption level, and science and technology level had the greatest impact on the change of carbon transfer. Regions with abundant resources but lower levels of science and technology, and higher levels of energy consumption will increase their carbon transfer. The results of this paper are intended to improve the study of carbon transfer along the value chain, and provide a basis for the division of responsibility for carbon emission reduction and the formulation of policies in China.
Causal relationship between gut microbiota and psoriasis: a two-sample Mendelian randomization study
Authors: Gao Chongxiang , Liu Minghui , Ding Jian 
Published: January 2024

Abstract
Background
Accumulating evidence from observational and experimental studies suggests a potential association between the gut microbiota (GM) and psoriasis, yet it remains obscure whether this connection is causal in nature.
Methods
By performing a two-sample Mendelian Randomization (MR) analysis of genome-wide association study (GWAS) summary statistics from the MiBioGen and FinnGen consortium, the causal association between GM and psoriasis was investigated, using methods of inverse variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode.
Results
The genus Eubacterium fissicatena group (odds ratio [OR]: 1.22, 95% confidential interval [CI], 1.09–1.36, P < 0.001) and genus Lactococcus (OR: 1.12, 95% CI: 1.00-1.25, P = 0.046) were identified as risk factors for psoriasis, while the genus Butyricicoccus (OR: 0.80, 95% CI: 0.64-1.00, P = 0.049), genus Faecalibacterium (OR: 0.84, 95% CI: 0.71–0.99, P = 0.035), genus Prevotella9 (OR: 0.88, 95% CI: 0.78–0.99, P = 0.040) exhibited protective effects against psoriasis. The sensitivity analysis did not provide any indications of pleiotropy or heterogeneity.
Conclusions
Our two-sample MR analysis provides novel evidence supporting the causality between GM and psoriasis. Comprehensive and multi-omics methods are warranted to unravel the contribution of GM to psoriasis pathogenesis, as well as its potential therapeutic implications.
Acceptability and usefulness of the EORTC ‘Write In three Symptoms/Problems’ (WISP): A brief open-ended instrument for symptom assessment in cancer patients
Authors: Rojas-Concha Leslye , Arrarras Juan Ignacio , Conroy Thierry , Chalk Tara , Guberti Monica , Holzner Bernhard , Husson Olga , Kuliś Dagmara , Shamieh Omar , Piccinin Claire , Puga María José , Rohde Gudrun , Groenvold Mogens 
Published: January 2024

Abstract
Background
The use of open-ended questions supplementing static questionnaires with closed questions may facilitate the recognition of symptoms and toxicities. The open-ended ‘Write In three Symptoms/Problems (WISP)’ instrument permits patients to report additional symptoms/problems not covered by selected EORTC questionnaires. We evaluated the acceptability and usefulness of WISP with cancer patients receiving active and palliative care/treatment in Austria, Chile, France, Jordan, the Netherlands, Norway, Spain and the United Kingdom.
Methods
We conducted a literature search on validated instruments for cancer patients including open-ended questions and analyzing their responses. WISP was translated into eight languages and pilot tested. WISP translations were pre-tested together with EORTC QLQ-C30, QLQ-C15-PAL and relevant modules, followed by patient interviews to evaluate their understanding about WISP. Proportions were used to summarize patient responses obtained from interviews and WISP.
Results
From the seven instruments identified in the literature, only the free text collected from the PRO-CTAE has been analyzed previously. In our study, 161 cancer patients participated in the pre-testing and interviews (50% in active treatment). Qualitative interviews showed high acceptability of WISP. Among the 295 symptoms/problems reported using WISP, skin problems, sore mouth and bleeding were more prevalent in patients in active treatment, whereas numbness/tingling, dry mouth and existential problems were more prevalent in patients in palliative care/treatment.
Conclusions
The EORTC WISP instrument was found to be acceptable and useful for symptom assessment in cancer patients. WISP improves the identification of symptoms/problems not assessed by cancer-generic questionnaires and therefore, we recommend its use alongside the EORTC questionnaires.