bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural equation model of the spatial distribution of water engineering facilities along the Beijing-Hangzhou grand canal and its relationship with natural factors
Authors: Cheng Wang , Yiwen Zhang , Liang Li , Yihua Yan , Guanhua Wang , Xin Qiu , Yangqinxue Zeng 
Published: November 2023

Abstract
Water engineering facilities are a crucial component of the Beijing-Hangzhou Grand Canal during the Ming and Qing dynasties, and their distribution is closely related to the hydrological and topographical characteristics of the area. In this study, we reconstructed the canal network distribution map and water engineering facilities database of the Ming and Qing periods using ArcGIS (Geographical information systems software) 10.8 software. We employed Amos (Analyze of Moment Structures) 26.0 software to investigate the influence of various natural environmental factors on the selection of water engineering facility sites. The results revealed a significant correlation between the spatial distribution of water engineering facilities and the main channel slope and slope direction, which had a direct impact. The estimated coefficient for the main channel slope was -0.166, showing a negative correlation with the spatial distribution of water engineering facilities, while the estimated coefficient for the main channel slope direction was − 0.112, also indicating a negative correlation. Moreover, the estimated coefficient for the watershed area where water engineering facilities were located was -0.096, demonstrating a negative correlation. In contrast, the effects of tributary slope and slope direction on the spatial distribution of water engineering facilities were indirect, mediated by the watershed area where these facilities were situated. The effect size for tributary slope was -0.017, showing a negative correlation, while the effect size for tributary slope direction was 0.010, indicating a positive correlation with the spatial distribution of water engineering facilities.The study achieves the integration of the heritage of water engineering facilities along the canal from point to line, provides data support for the construction of the cultural heritage corridor of the canal, and facilitates the promotion of heritage protection and rational layout, which is of great significance to the understanding of the canal culture.
Effects of aligner activation and power arm length and material on canine displacement and periodontal ligament stress: a finite element analysis
Authors: Inan Aysegul , Gonca Merve 
Published: November 2023

Abstract
Background
This study aimed to assess the impact of aligner activation and power arm length and material on canine and aligner displacement, von Mises stress in the power arm, and principal stress in the periodontal ligament (PDL) during canine tooth distalization using finite element analysis (FEA). The effects of aligner activation and power arm length were primary outcomes, while the effect of the power arm material was a secondary outcome.

Methods
Aligner activation (0.1 mm or 0.2 mm) was applied without using a power arm in two models. The effects of aligner activation, power arm length (12, 13, or 14 mm) and power arm material (stainless steel [SS] or fiber-reinforced composite [FRC]) on canine distalization were investigated in 12 models by evaluating displacement and stress via ALTAIR OptiStruct analysis.

Results
Greater canine displacement was observed in all models with 0.2 mm than 0.1 mm of aligner activation. When models with the same aligner activation were compared, reduced mesiodistal tipping, increased palatal tipping, and increased extrusion of the canine cusp were observed with increasing power arm length. Moreover, the von Mises stress increased as the power arm length increased. Increasing the aligner activation and power arm length increased the maximum principal stress in the PDL. Power arms of the same length in both materials showed the same results in terms of canine displacement, clear aligner displacement, and maximum principal stress in the PDL. However, under conditions of equal length and aligner activation, the von Mises stress of the SS power arm was higher than that of the FRC power arm.

Conclusion
Using a power arm in canine distalization reduced mesiodistal tipping but increased palatal tipping and extrusion of the canine cusp. Aligner activation and additional force increased tooth movement and principal stress in the canine PDL. FRC power arms exhibited less von Mises stress than SS power arms.
Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1
Authors: La Yeo Kyung , Gunasekaran Pethaiah , Yim Min Su , Lee Gong-Hyeon , Hwang Yeon Sil , Damodharan Kannan , Kim Mi-Hyun , Bang Jeong Kyu , Ryu Eun Kyoung 
Published: November 2023

Abstract
Objectives
Polo-like kinase 1 (Plk1) is an important mitotic protein. In particular, this protein is highly overexpressed in many types of tumors and has been identified as a potential biomarker for the treatment and diagnosis of tumors. Plk1 is composed of two domains, an N-terminal kinase domain and a C-terminal polo-box domain (PBD). Presently, inhibitors with improved selectivity and specificity for Plk1 are unavailable. Therefore, we aimed to develop an inhibitor targeting the C-terminal PBD present only in Plk1.

Methods & results
In this study, three derivatives targeting PBD for Plk1 were designed by protein–protein interactions, which showed high levels of selectivity and specificity for Plk1 PBD, and were evaluated to inhibit tumor cell proliferation through an apoptotic process during tumor cell division. The investigation of the in vitro and in vivo antitumor effects of these inhibitors demonstrated that one of the new small molecules, 1, is a promising anticancer agent.

Conclusion
Our findings can provide new insights for the design of novel Plk1 peptide inhibitors in the future.
Prevalence of food insecurity and associated factors among households in Waliso town, Oromia, Ethiopia
Authors: Tulem Tariku Gurara , Hordofa Mulatu Ayana 
Published: November 2023

AbstractBackgroundFood insecurity is the underlying cause of malnutrition. In addition, it is a condition where people lack consistent access to enough food for every person in a household to live an active and healthy life.Recently, urban food insecurity has been on the top agenda in Ethiopia, as households prone to food insecurity are rising because of various factors. Hence, we aimed to assess the prevalence of food insecurity and associated factors among households in Waliso town, Oromia, Ethiopia.MethodsA community-based cross-sectional study design was used from December 17, 2021, to January 16, 2022, among 397 randomly selected households in Waliso town. Study participants were selected using a simple random sampling technique. Data collection was performed using a structured questionnaire, and data were entered using Epi Info 7 and exported to SPSS version 20 software for analysis. To identify factors associated with household food insecurity, multivariable binary logistic regression analyses were done. An adjusted odds ratio along with a 95% confidence interval were estimated to measure the strength of the association. In this study, the level of statistical significance was declared at p < 0.05.ResultsThe prevalence of household food insecurity was 63.4%, 95% CI (58.60%, 68.20%). Factors associated with household food insecurity were family sizes 6 + [AOR = 3.06, 95% CI: (1.35, 6.94)], dependents 1–2 [AOR = 2.62, 95% CI: (1.35, 5.10)], dependents 3 + [AOR = 3.07, 95% CI: (1.38, 7.40)], unemployed [AOR = 6.86, 95% CI: (2.76, 17.04)], self-employed [AOR = 3.27, 95% CI: (1.50, 7.14)], wage laborers [AOR = 13.01, 95% CI: (4.93, 34.38)], low wealth index [AOR = 4.08, 95% CI: (2.18, 7.64)], and a medium wealth index [AOR = 2.08, 95% CI: (1.18, 3.69)].ConclusionNearly two in three households were food insecure in Waliso Town. Large family sizes, a high dependency ratio, unemployment, low wage employment, and a low wealth index were significantly associated with food insecurity. Hence, the implementation of actions to improve household income and livelihoods, minimize dependency rates, by strengthen the use of family planning and encourage urban agriculture is vital to alleviate household food insecurity problems in the town.
Study protocol: maintaining preventive care during public health emergencies through effective coordination
Authors: Hysong Sylvia J. , Giardina Traber Davis , Freytag Jennifer , SoRelle Richard , Murphy Daniel R. , Cully Jeffrey A. , Sada Yvonne H. , Amspoker Amber B. 
Published: November 2023

Abstract
Background
Screening lies at the heart of preventive care. However, COVID-19 dramatically disrupted routine screening efforts, resulting in excess mortality not directly attributable to COVID-19. Screening rates during COVID varied markedly by facility and clinical condition, suggesting susceptibilities in screening and referral process workflow. To better understand these susceptibilities and identify new practices to mitigate interrupted care, we propose a qualitative study comparing facilities that exhibited high, low, and highly variable performance (respectively) in screening rates before and during the pandemic. We will be guided by Weaver et al.’s multi-team systems (MTS) model of coordination, using cancer and mental health screening rates as exemplars.

Method
Qualitative analysis of interviews and focus groups with primary care personnel, leadership, and patients at 10 VA medical centers. We will select sites based on rurality, COVID-19 caseload at the beginning of the pandemic, and performance on five outpatient clinical performance indicators of cancer and mental health screening. Sites will be categorized into one of five screening performance groups: high performers, low performers, improvers, plummeters, and highly variable.
We will create process maps for each performance measure to create a workflow baseline and then interview primary care leadership to update the map at each site. We will clinician conduct focus groups to elicit themes regarding clinician coordination patterns (e.g., handoffs), strategies, and barriers/facilitators to screening during COVID. We will also conduct patient interviews to examine their screening experience during this period, for context. All interviews and focus groups will be audio-recorded, transcribed, and enhanced by field notes. We will analyze clinician transcripts and field notes using iterative, rapid analysis. Patient interviews will be analyzed using inductive/deductive content analysis.

Discussion
Our study represents a unique opportunity to inform the multi-team systems literature by identifying specific forms of information exchange, collective problem solving, and decision-making associated with higher and improved clinical performance. Specifically, our study aims to detect the specific points in the screening and referral process most susceptible to disruption and coordination processes that, if changed, will yield the highest value. Findings apply to future pandemics or any event with the potential to disrupt care.
Effects of cochlear implantation on auditory temporal processing in single-sided deafness: a report of two cases
Authors: Gumus Birgul , Incesulu Armagan , Kaya Ercan 
Published: November 2023

Abstract
Background
Individuals with single-sided deafness have difficulty understanding speech in noise and determining sound direction in their daily lives. Cochlear implantation, a globally accepted rehabilitation method, has recently become used in Turkey in patients with single-sided deafness. In this study, the effects of cochlear implants on auditory temporal processing skills, speech-in-noise perception performance, tinnitus, and subjective benefit were reported in two patients with single-sided deafness.

Case presentation
The cochlear implant was applied to two children with single-sided deafness with and without inner ear malformation. Speech in noise score, gaps in noise test, duration, and frequency pattern test were used. Also, cochlear implant benefits and the presence of tinnitus were questioned by questionnaires. Speech-in-noise perception performance and auditory temporal processing skills improved in the postoperative period compared to the preoperative period. It was also observed that although the cochlear implant improved the quality of life, motivation for device use decreased in the first 6 months of the postoperative period.

Conclusions
Cochlear implantation in individuals with single-sided deafness with and without inner ear malformation is useful in increasing auditory temporal processing skills and understanding speech in noise ability. In addition, cochlear implantation is a useful method to improve quality of life, especially regarding spatial perception, and it did not cause tinnitus in our patients. Selecting an implant model that enables data logging provides an advantage in determining the motivation to use the implants.
Caenorhabditis elegans germ granules are present in distinct configurations and assemble in a hierarchical manner
Authors: Uebel Celja J. , Rajeev Sanjana , Phillips Carolyn M. 
Published: November 2023

ABSTRACT
RNA silencing pathways are complex, highly conserved, and perform crucial regulatory roles. In Caenorhabditis elegans germlines, RNA surveillance occurs through a series of perinuclear germ granule compartments – P granules, Z granules, SIMR foci, and Mutator foci – multiple of which form via phase separation. Although the functions of individual germ granule proteins have been extensively studied, the relationships between germ granule compartments (collectively, ‘nuage’) are less understood. We find that key germ granule proteins assemble into separate but adjacent condensates, and that boundaries between germ granule compartments re-establish after perturbation. We discover a toroidal P granule morphology, which encircles the other germ granule compartments in a consistent exterior-to-interior spatial organization, providing broad implications for the trajectory of an RNA as it exits the nucleus. Moreover, we quantify the stoichiometric relationships between germ granule compartments and RNA to reveal discrete populations of nuage that assemble in a hierarchical manner and differentially associate with RNAi-targeted transcripts, possibly suggesting functional differences between nuage configurations. Our work creates a more accurate model of C. elegans nuage and informs the conceptualization of RNA silencing through the germ granule compartments.
The reduction in arterial pH with increased temperature is not affected by hyperoxia in toads (Rhinella marina) and pythons (Python molurus)
Authors: Castro Samanta Aparecida , Leite Cléo Alcantara Costa , Wang Tobias 
Published: November 2023

ABSTRACT
It is well established that arterial pH decreases with increased temperature in amphibians and reptiles through an elevation of arterial PCO2, but the underlying regulation remains controversial. The alphastat hypothesis ascribes the pH fall to a ventilatory regulation of protein ionisation, but the pH reduction with temperature is lower than predicted by the pKa change of the imidazole group on histidine. We hypothesised that arterial pH decreases at high, but not at low, temperatures when toads (Rhinella marina) and snakes (Python molurus) are exposed to hyperoxia. In toads, hyperoxia caused similar elevations of arterial PCO2 at 20 and 30°C, indicative of a temperature-independent oxygen-mediated drive to breathing, whereas PCO2 was unaffected by hyperoxia in snakes at 25 and 35°C. These findings do not support our hypothesis of an increased oxygen-mediated drive to breathing as body temperature increases.
Internal Revision with Bleb Needling: An Effective, Safe Option for Failing Blebs
Authors: Singh Kirti , Sachdev Neha , Singh Arshi 
Published: November 2023

Aim: To report the outcomes of internal revision with bleb needling in cases of failing blebs with the internal sclerostomy blocked by iris tissue.
Methods: Prospective study of 26 eyes of 26 patients with failing blebs where target IOP was not achieved with 2 anti-glaucoma drugs and sclerostomy was blocked by iris (confirmed on gonioscopy). Patients were divided into 3 groups depending on the time from the first surgery- early (<3 months), intermediate (4-12 months) and late (>1 year). Patients underwent internal revision with bleb needling with either 5-Fluorouracil (5-FU) or Mitomycin C (MMC)
Results: 26 eyes of 26 patients were included in the study. Mean age was 51.35±14.5 years. Time from the filtration surgery was early in 3, intermediate in 5 and late in 18 eyes. Mean IOP reduction at 3 months was 32±18% with maximum reduction in early group (40%). Mean IOP decreased from 24.5±3.4 mmHg to 16.2±4.3 mmHg in 5-FU group (12 patients) and 27.4±9 mmHg to 18.2±6.6 mmHg in MMC group (14 patients). Self-limiting complications were hyphema in 2 patients and subconjunctival haemorrhage in 1 patient.
Conclusion: Internal revision with bleb needling is a safe and effective procedure for reviving failing blebs.
Pre- and Post-COVID-19 Outcomes for Israelis With Intellectual and Developmental Disabilities in the Community
Authors: Gur Ayelet , Soffer Michal , Blanck Peter D. , Quinn Gerard , Rimmerman Arie 
Published: November 2023

Abstract
This study is among the first pre–post examinations to explore differences in subjective well-being, adaptive and maladaptive behavior, close relationships, community integration, family members’ satisfaction with residential and community living settings, and family contact before and after the COVID-19 outbreak. Participants demonstrated better life satisfaction and adaptive behavior before COVID-19 than after COVID-19. Participants reported closer relationships with family members and peers before COVID-19 and closer relationships with staff members after COVID-19. The findings reveal mixed, although mostly negative, effects of the pandemic on people with intellectual and developmental disabilities in the community in Israel, in accord with extant comparative research.
Supporting Employment Consultants to Implement Supported and Customized Employment
Authors: Butterworth John , Migliore Alberto , Lyons Oliver , Mahoehney Danielle C. , Eastman Jill , Miles Britni , Foos Paul , Zalewska Agnieszka 
Published: November 2023

Abstract
Implementing supported and customized employment in all their components is essential for supporting job seekers with disabilities to achieve their career goals. We asked 42 employment consultants in nine employment programs to respond daily to three quick questions about their employment support activities, for 6 months. Through monthly coaching, we helped the managers of these organizations engage their teams of employment consultants to interpret the data, reflect, set goals, and take action for quality improvement. Based on the positive results of this pilot, we recommend that employment consultants be provided with data-enabled feedback that supports decision making and helps them fully implement supported and customized employment as a necessary step toward improving job seekers’ employment outcomes.
Direct Support Professionals and COVID-19 Vaccination: A Comparison of Vaccinated Early Adopters and In-Betweeners
Authors: Pettingell Sandra L. , Bershadsky Julie , Hewitt Amy , Anderson Lynda Lahti , Zhang Alicia 
Published: November 2023

Abstract
Direct support professionals (DSPs) are at increased risk of contracting COVID-19. A four-wave survey series was conducted, in part, to understand DSPs’ COVID-19 vaccination experiences. Fourth wave data were used to compare those vaccinated against COVID-19 when they became eligible (early adopters) and those waiting at least three months before vaccination (in-betweeners). Findings indicated that in-betweeners were more likely to be female, younger, and people of color with lower education levels and annual incomes, with employers requiring COVID-19 vaccination to remain employed. COVID-19 vaccination motivators included protection for self, family, or people supported; an employer who mandated COVID-19 vaccination; and having had COVID-19 or knowing someone who did.
Evaluation of an infection control protocol to limit COVID-19 at residential summer camps in 2021
Authors: Weiss Tirzah , Reuter Tate , Dowell Evan , Singstock Mitchell , Smith Katherine , Schlaudecker Jeffrey 
Published: November 2023

Aim
To assess the effectiveness of an infection control protocol developed to mitigate the spread of COVID-19 at two multi-week residential summer camps in 2021.

Subject and methods
Data were collected from 595 camp attendees and staff members at two wilderness camps in Northern Minnesota. Testing was undertaken in all unvaccinated campers before arrival at camp, on day 4 of camp, and in the event of respiratory symptoms. Campers were limited to cohorts during the first 4 days of camp and wore masks indoors. The number of positive COVID-19 cases measured the efficacy of the protocol.

Results
The testing and cohorting protocol successfully prevented the spread of COVID-19 among campers and staff. During the first summer session, there were zero positive cases of COVID-19 among 257 campers and 127 staff. During the second summer session, compliance with the protocol limited the spread of COVID-19 to just three individuals of 266 campers and 129 staff. Maintaining cohorts at arrival limited spread from a single positive case to only two tent companions.

Conclusion
The testing and cohorting protocol limited the spread of COVID-19 among residential summer wilderness campers and staff. Post-arrival testing ensured newly acquired virus was limited in spread before COVID-19 precautions were relaxed on camp day 5. A strict evidence-based cohorting protocol limited in-camp spread and allowed for a successful summer camp season. The usefulness of this protocol with an evolving pandemic, increasing vaccination rates, and virus variants could have implications for future practice.