bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between atmospheric particulate matter pollution during pregnancy and premature birth in China: a meta-analysis
Authors: Guo Bingbing , Jiang Xinye 
Published: January 2025

ObjectiveThe impact of maternal exposure to outdoor particulate matter during pregnancy on preterm birth is still inconsistent, particularly under the unique atmospheric particulate matter pollution conditions in China, where the effects on preterm birth remain poorly understood. The study intends to evaluate the correlation between atmospheric particulate matter pollution (PM2.5 and PM10) during pregnancy and premature birth in China through a Meta-analysis.MethodsThe Chinese databases (CNKI and Wanfangdata), and the English databases (PubMed, Web of Science, and Embase) were searched to collect literature related to exposure to atmospheric particulate matter during pregnancy in China and premature birth. A Meta-analysis was conducted using Stata12.0 software.ResultsA total of 29 studies were included in this study (15 cross-sectional studies, 11 cohort studies, and 3 case–control studies), covering more than 30 provinces (municipalities directly under the Central Government) in China, with a total sample size of 9,283,110 people. The Meta-analysis results showed that the risk of premature birth with the OR value was 1.03 (95%CI:1.011.06) for exposure to PM2.5 in mid-pregnancy, 1.03 (95%CI:1.011.04) for exposure to PM2.5 in late pregnancy, 1.07 (95%CI:1.051.10) for exposure to PM2.5 throughout pregnancy, and 1.04 (95%CI:1.001.07) for exposure to PM10 throughout pregnancy. No correlation was found between exposure to atmospheric particulate matter at other times and the occurrence of premature birth.ConclusionAlthough our results indicate that exposure to atmospheric particulate matter during the second and third trimesters of pregnancy increases the risk of preterm birth among pregnant women in China, the association is relatively weak. Additionally, the results may be influenced by potential confounding factors. Therefore, further detailed research is needed to explore the relationship between particulate matter exposure and preterm birth or other adverse pregnancy outcomes.
Human papillomavirus vaccination hesitancy among young girls in Ethiopia: factors and barriers to uptake
Authors: Sendekie Ashenafi Kibret , Abate Biruk Beletew , Adamu Betelhem Anteneh , Tefera Aschalew Mulatu , Mekonnen Kaleab Temelket , Ashagrie Melkam Alemu , Tadesse Yabibal Berie , Dagnaw Abera Dessie , Melaku Mequannent Sharew , Bizuneh Gizachew Kassahun 
Published: January 2025

BackgroundHuman papillomavirus (HPV) vaccinations protect against HPV infections. The infection might lead to vaginal cancer, vulvar cancer, genital warts, cervical intraepithelial neoplasia lesions, and cervical cancer. This study assessed hesitancy of HPV vaccination, associated factors, and barriers to vaccination among youth girls in Ethiopia.MethodsAn institutional-based cross-sectional study was conducted among female undergraduate students at the University of Gondar, College of Medicine and Health Sciences, between July and August 2022. The data was collected using a self-administered questionnaire. A simple random sampling method was used to recruit participants. The data were entered and analyzed with SPSS version 26. Descriptive statistics were used to describe the participants’ demographic characteristics. Logistic regression was performed to identify the significant factors associated with acceptance of the HPV vaccine. A p-value &lt;0.05 was considered statistically significant.ResultsThe study included 423 participants with a mean age of 22.5 ± 6.7 years. Only more than one-third (35.2, 95% CI: 27.2–44.1) received the HPV vaccine. Currently, more than one-fourth (27.9, 95% Cl: 21.4–33.8) of participants are hesitant to receive the HPV vaccine. Higher monthly income (AOR = 1.52, 95% CI: 1.08–6.34), good knowledge of the HPV vaccine (AOR = 2.12, 95% CI: 1.12–4.87), and a positive attitude towards the vaccine (AOR = 3.03, 95% CI: 1.63–9.56) were significantly associated with acceptance of HPV vaccination. Safety concerns (63.1%), misinformation (42.8%), and parental concerns (42.3%) about the HPV vaccine were among the top perceived reported barriers to receiving the HPV vaccine.ConclusionThis result showed that more than a quarter number of youth girls are still hesitant to receive HPV vaccinations. To increase vaccination acceptance, interventions should focus on awareness-raising programs about HPV infection and vaccines and addressing safety and parental concerns.
Impact of neighborhood safety on adolescent physical activity in Saudi Arabia: gender and socio-economic perspectives
Authors: Addas Abdullah 
Published: January 2025

Background and objectivesAdolescent physical activity is a critical determinant of long-term physical and mental health. However, the factors influencing activity levels remain underexplored in rapidly urbanizing regions such as Saudi Arabia, where changing built environments pose unique challenges.MethodsThis study examined the relationship between neighborhood safety perceptions and physical activity levels among 1,500 adolescents aged 14–17 years in the cities of Riyadh, Jeddah, and Dammam, representing a mix of urban and suburban settings. This study used a cross-sectional design with data collected through a validated self-reported questionnaires and interviews; the data were analyzed through multivariate regression.ResultsThe results indicate that adolescents who perceived higher traffic-related safety concerns engaged in 30% less physical activity compared to those in safer neighborhoods (p &lt; 0.01). Female adolescents were 20% more likely than male adolescents to report safety concerns (p &lt; 0.05), while those residing in villas engaged in 15% more physical activity than their peers living in flats (p &lt; 0.05).ConclusionsThese findings underscore the significant role of neighborhood safety in shaping adolescent health behaviors, particularly regarding traffic management and accessibility. These results contribute to the growing evidence regarding the influence of built environments on youth health and wellbeing in rapidly urbanizing regions. The study offers actionable policy recommendations for urban planners and public health officials to create safer, more inclusive environments that encourage physical activity, especially among female adolescents. Future research should adopt longitudinal designs and incorporate objective measures, such as wearable activity trackers, to assess the long-term impact of neighborhood safety interventions on adolescent health outcomes.
Assessing factors influencing adolescent sexual debut in Nigeria: a multi-cluster survival analysis approach
Authors: Correa Fabio Mathias , Omaku Peter Enesi , Braimah Joseph Odunayo 
Published: January 2025

IntroductionEarly sexual debut is an area of concern in Nigeria with implications for reproductive health.MethodsThis study addresses this by proposing a more effective survival model—one that incorporates both independent and identically distributed (IID) and Besag intrinsically conditional auto-regressive (ICAR) random effect priors, using a generalised additive model that accounts for both individual and spatial influences on age at first sex. We analyse data from the 2018 Nigerian NDHS survey and compare our model with existing models: a model without the cluster frailty effect, a model that ignores the Besag ICAR and includes the IID, and a model that ignores the IID and includes only the Besag ICAR.ResultsOur approach, which combines independent and spatial random effects, outperforms others based on statistical criteria (Deviation Information Criterion and the Widely Applicable Information Criterion).DiscussionAs shown in this study, the proposed model effectively captures the complexity of age at first sex. In addition, visualisations reveal significant geographic and social clusters with high rates of early sexual debut in Nigeria. These findings highlight the importance of considering multi-level clustering to better understand and promote healthy sexual behaviour among young Nigerians through targeted interventions.
Early one-stage posterior-only surgery for congenital cervicothoracic scoliosis in children: medium- and long-term follow-up
Authors: Zhang Cefei , Liu Fuyun , Xu Ke , Hu Weiming , Xia Bing , Zhao Yufeng 
Published: January 2025

ObjectiveThe purpose of this study is to investigate the medium- and long-term correction outcomes and complications of early one-stage posterior-only surgery for congenital cervicothoracic scoliosis in children.MethodsFrom March 2006 to March 2022, we retrospectively investigated 33 consecutive cases of congenital cervicothoracic scoliosis treated by one-stage posterior-only surgery, including 15 males and 18 females, with a mean age of 3.2 years. Radiographic parameters, including segmental scoliosis, distal compensatory curve, T1 tilt, clavicle angle, neck tilt, coronal balance distance, segmental kyphosis, and sagittal vertical axis, were measured preoperatively, postoperatively, and at the last follow-up. The results of the measurements were statistically analyzed using paired-sample t-tests. Complications were recorded.ResultsThe mean operation time was 199.8 min (100–340 min) with an average blood loss of 261.5 ml (80–600 ml). The mean follow-up period was 75.8 months (28–182 months). Fusion levels averaged 3.4 segments (2–6 segments). The segmental scoliosis was improved from 48.2° ± 10.7° preoperatively to 10.0° ± 6.0° postoperatively (P &lt; 0.001), with a correction rate of 79.3% ± 11.2%. The distal compensatory curve was spontaneously corrected from 23.4° ± 9.8° preoperatively to 9.2° ± 5.7° postoperatively (P &lt; 0.001), with a correction rate of 58.8% ± 19.4%. One case of pleural rupture, three cases of transient nerve root injury, one case of Horner syndrome, and two cases of pleural effusion. Two cases underwent revision surgery due to loss of correction.ConclusionEarly one-stage posterior-only surgery for congenital cervicothoracic scoliosis in children can effectively correct the local deformities and improve the appearance, and the medium- and long-term correction outcomes are satisfactory. Hemivertebra resection without internal fixation may be considered for some very young children. For the higher level of thoracic hemivertebra, the osteotomy level being shifted down one vertebra is a feasible and safer surgical procedure.
High-parameter immunophenotyping reveals distinct immune cell profiles in pruritic dogs and cats
Authors: McDonald Erin , Kehoe Eric , Deines Darcy , McCarthy Mary , Wright Brie , Huse Susan 
Published: January 2025

IntroductionImmunophenotyping is a powerful tool for grading disease severity, aiding in diagnosis, predicting clinical response, and guiding the development of novel therapeutics.MethodsThis pilot study employs high parameter immunophenotyping panels (15 markers for dog, 12 for cat) and leverages unsupervised clustering to identify immune cell populations. Our analysis uses machine learning and statistical algorithms to perform unsupervised clustering, multiple visualizations, and statistical analysis of high parameter flow cytometry data. This method reduces user bias and precisely identifies cell populations, demonstrating its potential to detect variations and differentiate populations effectively. To enhance our understanding of cat and dog biology and test the unsupervised clustering approach on real-world samples, we performed in-depth profiling of immune cell populations in blood collected from client-owned and laboratory animals [dogs (n = 55) and cats (n = 68)]. These animals were categorized based on pruritic behavior or routine check-ups (non-pruritic controls).ResultsUnsupervised clustering revealed various immune cell populations, including T-cell subsets distinguished by CD62L expression and distinct monocyte subsets. Notably, there were significant differences in monocyte subsets between pruritic and non-pruritic animals. Pruritic dogs and cats showed significant shifts in CD62LHi T-cell subsets compared to non-pruritic controls, with opposite trends observed between pruritic cats and dogs.DiscussionThese findings underscore the importance of advancing veterinary immunophenotyping, expanding our knowledge about marker expression on circulating immune cells and driving progress in understanding veterinary-specific biology and uncovering new insights into various conditions and diseases.
Investigating the conditions in which women GPs thrive: a realist review protocol
Authors: Abrams Ruth , Jefferson Laura , Golder Su , Whiley Lilith , Park Sophie , Williams Vickie , Riley Ruth 
Published: January 2025

BackgroundWomen now make up approximately half of the GP workforce. However, many are leaving the profession. This could be because they experience higher rates of burnout, stress and anxiety, suicide, and lower rates of career progression. They also take on a greater load of emotional labour. Retaining this staff group is one of five priorities for future policy and research.AimThis research aims to synthesise the available evidence on how general practice workplaces can best support women GPs to thrive at work.Design & settingWe propose to undertake a realist review, which seeks to understand why an approach may work in specific contexts. This involves building an understanding of how contextual factors affect the activation of mechanisms (ie, changes in participant reasoning or behaviours) to produce their outcomes.MethodWe will locate available evidence on the topic, and, using a realist logic of analysis develop an understanding as to how, why, for whom and in what contexts women GPs thrive at work. Evidence will include: academic literature, policy documents, media items and guidelines.ResultsFindings will be co-disseminated with PPI and stakeholder members to all key groups including policymakers, employers, the public, and academic audiences by a wide variety of means.ConclusionThis review is intended to improve understanding of how working environments affect women GPs. It is anticipated that findings will support the implementation of strategies to better support this group to thrive at work.
Fraud Control Plan System: The Role Investigation Division In Fraud Prevention
Authors: Setiawan Desy Amaliati , Mais Rimi Gusliana , Kurniawan Rachmad Risqy , Sari Hastuti Indra 
Published: January 2025

The Financial and Development Supervisory Agency (BPKP) has an important and vital role in preventing corruption and fraud to create good governance that can be implemented in all government agencies. BPKP has made integrated efforts to prevent fraud and corruption, but in its implementation, there are still obstacles so that the achievement is considered less than optimal. This study aims to see the role of the Investigation Division of BPKP in preventing fraud by using the Fraud Control Plan (FCP) which consists of 10 attributes, namely: anti-fraud policy, anti-fraud structure, standards of behavior and discipline, fraud risk assessment, human resource management, third party management, whistleblowing system, proactive detection, investigation, and corrective action by conducting socialization of the use of FCP, diagnostic assessment, technical guidance, and evaluation. This study is a type of qualitative research, with data collection: interviews, observations, and documentation. Interviews were conducted with 3 key informants of BPKP Jakarta employees who work in the Investigation Division. The results of this study indicate that the Investigation Division has intensified fraud prevention by using the FCP. However, there are still agencies that are less concerned about this. The BPKP Investigation Division, by using the Fraud Control Plan, hopes to provide a major role and impact on fraud prevention, by mitigating, and facilitating the disclosure of fraudulent actions and it is recommended that every agency use and implement it to create an anti-fraud environment.
Evolução Funcional na fisioterapia de acordo com a CIF
Authors: Melim Diogo Pereria Carolina , Ozu Márcia Harumi Uema , Nishida Márjory Harumi , Gomes Juliana Leme , Lopes Uleida de Brito Lima , Narumia Lisa Carla 
Published: January 2025

Introdução. A Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) propõe a descrição de componentes de saúde, trazendo aspectos da funcionalidade e incapacidade como elementos centrais na reabilitação. Devido a sua abrangência e complexidade, este instrumento tem gerado desafios para os profissionais de saúde, em especial, para serviços voltados às pessoas com deficiência (PcD). A atenção às PcD requer um cuidado integral e ações consonantes entre as políticas públicas e serviços de saúde. Desafiando essas perspectivas, a CIF é utilizada como ferramenta diária dos profissionais na Associação de Assistência à Criança com Deficiência (AACD). Objetivo. Identificar o perfil funcional dos indivíduos atendidos nos três setores da fisioterapia em um centro de reabilitação física com base na CIF. Método. Estudo observacional descritivo e analítico realizado nos setores da fisioterapia infantil, adulto e aquática por meio da análise das planilhas de evolução setorial da população pediátrica e adulta atendida em 2021. Resultados. Analisadas 3.124 relatórios evoluções trimestral de 1.900 pacientes. As principais condições de saúde atendidas foram paralisia cerebral, lesões encefálicas adquiridas e amputação. A taxa de evolução funcional setorial foi de 80% com mudanças nos qualificadores. Houve prevalência nas escolhas dos objetivos relacionados com os domínios de atividade e participação nos três setores. Conclusão. A implementação desta ferramenta em centros de reabilitação auxilia na promoção de saúde e definição do plano terapêutico adequado. A evolução funcional dos PcD na instituição pode sugerir eficácia na promoção de uma linha de cuidados resolutiva frente às necessidades desta população.
The History of Japanese Christianity under the Microscope: A Study of the Second Stage of Repression in the Shimabara Domain (1625–30)
Authors: Nogueira Ramos Martin 
Published: January 2025

In the Shimabara domain, evangelization was successful in the sixteenth century after the conversion of its feudal lord (daimyo), Arima Harunobu (1561?–1612), in 1580. However, from 1612 to 1615, the first arrests and executions led by Harunobu’s successor Arima Naozumi (1586–1641) and the authorities of Nagasaki shook the Christian community. After ten years of (relative) respite, Matsukura Shigemasa (1574–1630)—daimyo of the domain since 1616—launched another wave of repression, which aimed at undermining the religious organization of the villages by cutting their links with the clergy and subduing local lay figures. From 1625 to 1630, more than seventy devotees lost their lives, and virtually the entire population of Shimabara formally denied Christianity. These five years are well documented by missionary sources and local Japanese chronicles. Previous research has generally neglected these documents or tackled them separately. This paper argues that their comparative examination enables us to study, from a micro perspective, the logic of repression, the balance of power in the villages, the ambivalent attitude of the Christians toward secrecy, and the apostolate of the remnant missionaries. In other words, these testimonies allow us to reassess the experience of the Christian communities under the ban from multiple points of view, a few years before the revolt of Shimabara-Amakusa (1637–38).
Взаимосвязь генетических вариантов генов предрасположенности к тромбофилиям с развитием венозных тромбозов у пациентов c дислипидемией, перенесших новую коронавирусную инфекцию COVID-19
Authors: Перевезенцев О. А. , Мамедов И. С. , Бурцев Д. В. 
Published: January 2025

Цель исследования. Установить взаимосвязь между риском возникновения венозных тромбозов после перенесенной инфекции COVID19 8 генетических вариантов ((F2 20210G>A, F5 1691G>A, F7 10976G>A, F13 G>T, ITGA2 807C>T, ITGB3 1565 T>C, PAI-1 -675 5G>4G) генов свертывающей системы у пациеноов с дислипидемией. Материал и методы. Были обследованы 147 пациента в возрасте от 28 до 55 лет с дислипидемией, у которых в течение года после перенесенной клинически выраженной COVID-19, подтвержденной методами молекулярно-генетической диагностики SARS-CoV-2, были выявлены эпизоды венозных тромбозов различных локализаций, и 137 пациент группы сравнения в возрасте от 27 до 54 лет, у которых после перенесенной инфекции данных эпизодов не наблюдалось. Молекулярно-генетический анализ генетических вариантов генов системы гемостаза проводился методом ПЦР в реальном времени с автоматическим анализом кривых плавления. Результаты. По результатам анализа ассоциации генетических вариантов с венозными тромбозами у пациентов, которые перенесли новую коронавирусную инфекцию, связь с данной патологией была установлена для 2 генетических вариантов, ITGA2 807C>T (TT OR=4.15 (CI:2.25-7.65, P<0.0011)) и ITGB3 1565 T>C (генотип СС, OR =5.90 (CI: 1.79 – 19.50)). Заключение. Таким образом, мы установили ассоциацию 2 генетических вариантов (ITGA2 807C>T и ITGB3 1565 T>C) с венозными тромбозами у пациентов с дислипидемией, перенесших COVID19.
Использование современных методов обучения
Authors: Исакова М.Н. , Алиева М.К. 
Published: January 2025

В статье рассмотрена необходимость использования современных методов в учебном процессе. Так как успешной и эффективной может быть только такая система образования, которая понимает запросы своего времени и четко реагирует на них. Современный учитель должен понимать, что влияет на формирование личности в 21 веке и какие навыки способствуют самореализации учащихся. В настоящее время практически каждый педагог ищет наиболее подходящую технологию обучения для усовершенствования учебного процесса, повышения заинтересованности обучающихся и роста успеваемости. Поэтому на занятиях необходимо стараться подобрать такие методы обучения, которые позволят учащимся достичь целей обучения.
The article discusses the need to use modern methods in the educational process. Since only an education system that understands the needs of its time and clearly responds to them can be successful and effective. A modern teacher should understand what influences personality formation in the 21st century and what skills contribute to student self-realization. Currently, almost every teacher is looking for the most suitable teaching technology to improve the educational process, increase student interest and increase academic performance. Therefore, in the classroom, you must try to choose such teaching methods that will allow students to achieve the learning objectives.