bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with health-related quality of life in patients undergoing percutaneous coronary intervention: Thai PCI registry
Authors: Siriyotha Sukanya , Pattanaprateep Oraluck , Srimahachota Suphot , Sansanayudh Nakarin , Thakkinstian Ammarin , Limpijankit Thosaphol 
Published: November 2023

BackgroundPercutaneous coronary intervention (PCI) has been shown to improve health-related quality of life (HRQoL) in patients with coronary artery disease (CAD). The objectives of this study were to assess the changes in HRQoL and factors influencing these changes in CAD patients after undergoing PCI.MethodsData from a nationwide PCI registry across 39 hospitals in Thailand were collected in 2018–2019, including baseline characteristics, comorbid diseases, angiographic CAD severity, procedural details, and type of health insurance. HRQoL, as measured by utility scores, was determined in all patients using the Thai version of EQ-5D-5l at admission, discharge, and 6 and 12 months after discharge. The effects of time after PCI procedure and various factors on mean utility scores were assessed using a mixed-effect linear regression model.ResultsA total of 19,701 patients were included in the analysis; they had a mean age of 64.2 ± 11.7 years and were predominantly (69.1%) male. Following PCI, the mean utility scores increased from 66.6 ± 19.6 at admission to 81.9 ± 13.8 at discharge, and remained stable at 6 and 12 months (86.1 ± 12.3 and 88.0 ± 11.7, respectively). After adjusting for potential confounding variables, several factors were found to be independently associated with improved HRQoL, including angiographic success, male gender, overweight status, dyslipidemia, and radial access. Six other factors were associated with less improved HRQoLs, including cardiogenic shock/IABP support, old age, CKD, clinical presentation (STEMI and NSTEMI), prior cerebrovascular disease, and heart failure. There were no associations of CAD severity and procedural details with HRQoL. No differences were found related to type of health insurance, except that patients who were uninsured or self-pay tended to have less improvement in HRQoL.ConclusionHRQoL improved significantly after PCI in these subjects, as observed through 1 year of follow-up. Identifying the factors influencing these improvements may assist clinicians in tailoring patient interventions to optimise quality of life after PCI.
Research on the dismantling of double-arch tunnel after long-term service—the case study of Huangmeishan Tunnel demolition project
Authors: Kou Xinyu , Li Xiaojun , Xie Jiangning , Rusuli Adili , Li Tao , Rui Yi 
Published: November 2023

Mountain tunnel structures are subject to a variety of diseases with increasing service life. Earlier tunnels may need to be demolished and expanded because of the poor serving capacity. But few studies of tunnel demolition projects are available. Based on the demolition project of Huangmeishan Tunnel, this paper discusses the demolition scheme of the double-arch tunnel, calculates the stability of the slope, and investigates the defects and material performance in the tunnel. The water leakage in the tunnel mainly occurred at the mid-partition wall and the drainage pipe was clogged severely. The largest width of the crack detected is 15 mm. Material performance tests indicated that the concrete material strength exceeded the design values. In the loading test, the largest displacements of the tunnel arch and haunch were 1.73 and 1.32 mm, which verified the safety of heavy vehicles in construction. Finally, suggestions are given to avoid similar phenomena in other tunnels during the design, construction, and operation phase. The novelty of this study lies in its comprehensive analysis of a tunnel demolition project. The findings of this study contribute to enhancing the knowledge and understanding of tunnel demolition and support the safe and efficient execution of future demolition projects.
Novel nomogram for predicting survival in advanced non-small cell lung cancer receiving anti-PD-1 plus chemotherapy with or without antiangiogenic therapy
Authors: Wu Yahua , Lv Chengliu , Lin Mingqian , Hong Yaping , Du Bin , Yao Na , Zhu Yingjiao , Ji Xiaohui , Li Jiancheng , Lai Jinhuo 
Published: November 2023

BackgroundThis study aimed to develop and validate a novel nomogram to predict survival in advanced non-small cell lung cancer (NSCLC) receiving programmed cell death 1 (PD-1) inhibitor plus chemotherapy with or without antiangiogenic therapy.MethodsA total of 271 patients with advanced NSCLC who received anti-PD-1 plus chemotherapy with or without antiangiogenic therapy were enrolled in our center and randomized into the training cohort (n = 133) and the internal validation cohort (n = 138). Forty-five patients from another center were included as an independent external validation cohort. The nomogram was created based on the multivariate Cox regression analysis to predict overall survival (OS) and progression-free survival (PFS). The performance of the nomogram was assessed using the concordance index (C-index), the time-dependent area under the receiver operating (ROC) curves (AUCs), calibration curves, and decision curve analysis (DCA).ResultsFour factors significantly associated with OS were utilized to create a nomogram to predict OS: Eastern Cooperative Oncology Group performance status (ECOG PS), programmed cell death-ligand 1 (PD-L1) expression, chemotherapy cycle, and pretreatment lactate dehydrogenase–albumin ratio (LAR). Six variables significantly associated with PFS were incorporated into the development of a nomogram for predicting PFS: ECOG PS, histology, PD-L1 expression, chemotherapy cycle, pretreatment platelet to lymphocyte (PLR), and pretreatment LAR. The C-indexes of the nomogram for predicting OS and PFS were 0.750 and 0.747, respectively. The AUCs for predicting the 6-month, 12-month, and 18-month OS and PFS were 0.847, 0.791, and 0.776 and 0.810, 0.787, and 0.861, respectively. The calibration curves demonstrated a good agreement between predictions and actual observations. The DCA curves indicated that the nomograms had good net benefits. Furthermore, the nomogram model was well-validated in the internal and external cohorts.ConclusionThe novel nomogram for predicting the prognosis of advanced NSCLC receiving anti-PD-1 plus chemotherapy with or without antiangiogenic therapy may help guide clinical treatment decisions.
The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study
Authors: Xing Mengchen , Ni Yanlan , Zhang Ye , Zhao Xiaoqian , Yu Xin 
Published: November 2023

BackgroundIt has been reported that decreased muscle mass combined with excessive visceral adipose tissue are significantly correlated with the risk of non-alcoholic fatty liver disease (NAFLD). However, it has not been explored among populations with metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes. We aimed to investigate whether appendicular skeletal muscle mass to visceral fat area ratio (SVR), an indicator of sarcopenic obesity, influences on the risk of MAFLD subtypes and its hepatic condition in middle-aged and elderly population.MethodsA total of 4,003 middle-aged and elderly subjects were finally enrolled in this single-center retrospective study. Abdominal ultrasonography was employed for hepatic steatosis diagnosis. Participants were divided into four groups: diabetes-MAFLD, overweight/obese-MAFLD, lean-MAFLD and no MAFLD. Appendicular skeletal muscle mass as well as visceral fat area (VAF) was estimated by bioimpedance analysis measurements. Liver fibrosis was defined as a Fibrosis-4 index (FIB-4) and the NAFLD Fibrosis Score (NFS). Multivariate logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval between SVR and MAFLD subtypes/hepatic condition stratified by sex.ResultsParticipants with MAFLD subtypes had a significant lower value of SVR compared with those without MAFLD (P&lt;0.001), while high quartiles of FIB-4 and NFS also showed a decreasing value of SVR in comparison with its lower quartiles (Pfor trend&lt;0.001). The lowest quartile of SVR increased the prevalence of MAFLD subtypes [adjusted OR (95%CI): 2.96 (1.48 ~ 5.93) male /3.30(1.46 ~ 7.46) female for diabetes-MAFLD, 1.91(1.26 ~ 2.88) male /4.48(1.91 ~ 10.49) female for overweight/obese-MAFLD and 4.01(1.46 ~ 10.98) male/2.53(1.19 ~ 5.37) female for lean-MAFLD groups] compared with the highest quartile of SVR (all Pfor trend&lt;0.001). Besides, the interaction effect of gender on the relationship between SVR and MAFLD subtypes was statistically significant (all Pfor interaction&lt;0.001).Restricted cubic spline indicated an inverse association between SVR and the risk of MAFLD subtypes with linearity (all P for non-linearity&gt;0.05). The lowest quartile of SVR also increases the risk of MAFLD fibrosis in both males and females.ConclusionOur study concluded that a decrease in SVR (appendicular skeletal muscle mass divided by visceral fat area) is significantly associated with an increased prevalence of developing MAFLD subtypes and liver fibrosis in middle-aged and older persons of both genders.
Barriers to the development of community-based nursing in Iran
Authors: Peyrovi Hamid , Seyedfatemi Naiemeh , Goharinezhad Salime , Oghli Saeid Hossein 
Published: November 2023

PurposeToday, the care of chronic patients and older adult people in hospitals has moved towards community-based care, and health systems focus on disease prevention, health promotion, and rehabilitation. Community-based nurses play an essential role in early identification and intervention for these conditions. On the other hand, there is an increasing trend in ageing and chronic diseases in the world especially in Iran, which increases the importance of disease prevention and public health promotion. Therefore, the current research aims to identify barriers to the development of community-based nursing in Iran.MethodsIn this qualitative study, 12 semi-structured interviews were conducted with nursing experts recruited in the study by purposive sampling in 2021–2022. Interviews were recorded and transcribed and a framework analysis method was used to analyse the data.ResultsThe results obtained from the analysis of documents and qualitative interviews led to the identification of 4 barriers: not having a specific position, inappropriate image of nursing in society, inadequacy of education with the needs of society, and high cost of home nursing services.ConclusionImproving the image of nursing in society, locating a special place in the health system, improving education, and adjusting the costs of home care could be the strategies that help the further development of community-based nursing (CBN).
Evolution of psychopathology, purpose in life, and moral courage in healthcare workers during the COVID-19 pandemic: a longitudinal study
Authors: Echeverria Iván , Roselló-Jiménez Lorena , Benito Ana , Rojas-Bernal Luz Angela , O’Higgins Marcelo , Haro Gonzalo 
Published: November 2023

IntroductionAlmost 2 years and five infection waves after the COVID-19 pandemic started, healthcare workers continued dealing with the pandemic situation and facing the health consequences and the mental health disorders it caused. This study aimed to evaluate the onset and progression of psychopathology as well as the role of predictor variables such as purpose in life and moral courage among healthcare workers during this time.Materials and methodsThis was a longitudinal prospective study carried out with 45 Spanish healthcare workers who answered two questionnaires, the first questionnaire in April–May 2020 (T1) and the second questionnaire in September–October 2021 (T2).ResultsAlthough 29.5% of the sample considered that their mental health had improved over this time, almost half of them (47.7%) said it had not changed, while 22.7% reported a decline in their mental health from the first time they were asked. Specifically, 46.8% presented anxiety, 23.4% depression, and 42.6% acute stress at T1, and 38.3% had anxiety, 17% depression, and 27.7% post-traumatic stress disorder at T2. Despite this, there were no differences between T1 and T2 anxiety scores (p = 0.53), although there was a decrease in depression (p = 0.03) and acute stress (p = 0.02) scores. Predictor variable outcomes such as purpose in life (p = 0.88) and moral courage (p = 0.86; p = 0.38) did not change over time, but when modelling the data, purpose in life predicted psychopathology at T1, which in turn affected the psychopathology results at T2.ConclusionThis study showed that, although psychopathology decreased over the months, its prevalence remained high. Even though the purpose in life predicted psychopathology at T1, it seems that once the psychopathology is established (T2), the factors that would improve it would be different from the protective factors that prevented its establishment, which become secondary.
Study of the isomeric yield ratio in the photoneutron reaction of natural holmium induced by laser-accelerated electron beams
Authors: Zhang Jingli , Qi Wei , Fan Wenru , Cao Zongwei , Luo Kaijun , Tan Changxiang , Zhang Xiaohui , Deng Zhigang , Zhang Zhimeng , Li Xinxiang , Yuan Yun , Luo Wen , Zhou Weimin 
Published: November 2023

Introduction: An accurate knowledge of the isomeric yield ratio (IR) induced by the photonuclear reaction is crucial to study the nuclear structure and reaction mechanisms. 165Ho is a good candidate for the investigation of the IR since the Ho target has a natural abundance of 100% and the residual nuclide has a good decay property.Methods: In this study, the photoneutron production of 164m, gHo induced by laser-accelerated electron beams is investigated experimentally. The γ-ray spectra of activated Ho foils are off-line detected. Since the direct transitions from the 164mHo are not successfully observed, we propose to extract the IRs of the 164m, gHo using only the photopeak counts from the ground-state decay.Results: The production yields of 164m, gHo are extracted to be (0.45 ± 0.10) × 106 and (1.48 ± 0.14) × 106 per laser shot, respectively. The resulting IR is obtained to be 0.30 ± 0.08 at the effective γ-ray energy of 12.65 MeV.Discussion: The present data, available experimental data, and TALYS calculations are then compared to examine the role of the excitation energy. It is found that besides the giant dipole resonance, the excitation energy effect also plays a key role in the determination of the IRs.
Bacterial Cultural Media Containing Lipopeptides for Heavy Oil Recovery Enhancement: The Results of Sand-Packed Column Experiment
Authors: Galitskaya Polina , Gordeev Alexander , Ezhkin Nikita , Biktasheva Liliya , Kuryntseva Polina , Selivanovskaya Svetlana 
Published: November 2023

Currently, microbial enhanced oil recovery (MEOR) is of great interest because of its potential high efficiency and low environmental impact. Biosurfactants, in the purified form or contained in the bacterial cultural media, are one of the promising directions in MEOR because they are more stable in response to different environmental factors than life microorganisms are. However, the extraction and purification of biosurfactants, as well as their working concentrations and efficacy in real oilfield conditions remain a challenge. In the present work, cultural media of two novel bacterial isolates (Bacillus pumilus and Peribacillus simplex) were used in a model experiment with sand pack columns to enhance the recovery of heavy oil from Romashkino oilfield (Russia). Using FTIR and TLC methods, it was demonstrated that both cultural media contained lipopeptides. In the genome of both bacterial isolates, genes srfAA, fenD and bamC encoding synthesis of surfactin, fengycin, and bacillomycin, respectively, were revealed. The oil recovery efficacy of cell-free cultural media after 24 h of cultivation was 34% higher and 16% lower as compared with synthetic surfactant for B. pumilus and P. simplex, respectively. It can be concluded that the high-cost step of biosurfactants separation and purification may be excluded, and cell free cultural media of the isolates may be directly used in field conditions to enhance the recovery of heavy oils.
Quand Dieu rit
Authors: Lys Daniel 
Published: November 2023

When God laughs.
What kind of laughter does God laugh ? No less than thirteen Hebrew radicals are used to express laughter in the Old Testament corpus. Using a detailed examination of these radicals and a schematic presentation of their interrelationships, Daniel Lys shows that God’s laugh, in the Old Testament, gives voice to anything from joy to sarcasm.
A STUDY OF ATTITUDES TOWARD MOBILE-ASSISTED LANGUAGE LEARNING OF CHINESE COLLEGE STUDENTS IN YUNNAN
Authors: Lu Yuxuan 
Published: November 2023

This study aims to investigate the Chinese undergraduate students’ attitudes toward using mobile-assisted language learning (MALL) in the English language learning. This study used quantitative method and focus on descriptive research design. 375 participants were selected by convenience sampling form population to do questionnaire survey. The findings presented that students have a moderately high level of attitude toward MALL (M=3.666, SD = 0.545) at the Yuxi Normal university. They are willing to try to learn and master the ability to learn using mobile devices if they are guided and taught. Based on research findings, it shows students need to receive some appropriate pre-training on the proper use of MALL to learn English. In addition, students may seek help from their teachers because they have problems they cannot solve when using MALL. Therefore, teachers also need to be trained to have the theoretical knowledge of how to operate MALL to provide better assistance to students.
INFLUENCE OF LENDING DECISIONS ON SMALL AND MEDIUM ENTERPRISES DEVELOPMENT (CASE OF VIETINBANK, TIEN GIANG PROVINCE, VIETNAM)
Authors: Huu Ai Tran , Minh Nguyên Le Thi 
Published: November 2023

Small and medium-sized enterprises (SMEs) in the world are an indispensable part of the national economy. Customer information is always an important input data for the banking industry. Currently, banks are facing the problem of information asymmetry because borrowers provide unreliable and transparent information (data on financial and non-financial statements).
Research approaches the theory of distribution of bank credit capital based on the theory of Asymmetric Information; The theory of adverse selection of credit markets; Moral hazard theory; Social capital theory; Theory of application in banking administration.
The results of the factors affecting the bank's lending decision from high to low: (1) Information about the relationship with the bank (MQHNH) (ES = 0.207, P = 0.000); (2) Information on the capacity of the owner of the enterprise (NLCSH) (ES = 0.158, P = 0.005); (3) Social Information (ESR) (ES = 0.111, P = 0.020); (4) Information on Collateral (TSTC) (ES = 0.100, P = 0.022); (5) Information on Corporate Finance (TCDN) (ES = 0.088, P = 0.005) and (6) Information on Credit History (LSTD) (ES = 0.070, P = 0.009).
RESEARCH ON THE QUALITY IMPROVEMENT OF GUIZHOU TOURISM COMMODITIES
Authors: Haonan Chen 
Published: November 2023

With the rapid development of social economy, tourism has gradually become one of the pillar industries of national economic development in various provinces of China. As one of the western provinces with extremely rich tourism resources, and due to the strong support of the state and provincial government, the tourism industry in Guizhou has achieved rapid development. This paper aimed to enrich the localization of tourism commodities and improve the quality of tourism commodities and to provide suggestions for the construction of the quality improvement path system of tourism commodities in Guizhou. Through the methods of literature review, theoretical interpretation, field investigation, classic case analysis, in-depth interview and questionnaire method, we have defined the types of tourist commodities in Guizhou, existing problems with their manufacture and sales, as well as the opportunities and challenges, it is concluded that the ways to improve the quality of tourist commodities in Guizhou province are as follows: searching for characteristics, concentrating investment, cooperating management, classifying promotion, innovation management, association participation, brand maintenance, perfect certification, creative publicity, joint marketing, benefit sharing, inclusive co-construction.
Higher N2 gas-flow rate ratios in O2- and Ar-containing feed gas mixtures enhance the cytotoxic effects of radical-activated medium against murine melanoma B16F10 cells
Authors: Hashimoto Kazunori , Ogawa Kazuma , Mori Yasumasa , Nishida Taiga , Hori Masaru , Murata Tomiyasu , Ito Masafumi 
Published: November 2023

Abstract
Radical-activated medium (RAM), produced from cold atmospheric plasma irradiation of liquid cell culture medium, is of significant interest for its potential application in cancer treatment. In this study, murine melanoma B16F10 cells were used to examine the anticancer activity of RAMs generated from various plasma feed gas mixtures. RAMs generated from plasma feed gases containing O2 decreased cell viability, which was enhanced by N2. Mitochondrial membrane potentials decreased, whereas caspase-9 and caspase-3 activity increased, suggesting an induction of mitochondria-mediated apoptosis. Interestingly, caspase-3 activity was enhanced when N2 was present in the plasma feed gas. Moreover, only RAM generated from plasma feed gases containing N2 and O2 activated caspase-12 and c-Jun N-terminal kinase, which suggests an induction of endoplasmic reticulum-mediated apoptosis. Overall, the results suggest that N2 in the feed gas during RAM production enhances its anticancer activity by triggering both endoplasmic reticulum and mitochondria-mediated cell death.
Infinite Primes, Quadratic Polynomials, and Fermat’s Criterion
Authors: Zaman Budee U 
Published: November 2023

<p> In this study, we explore the existence of an infinite number of primes represented by the quadratic polynomial 4(Mp − 2)2 + 1 . We propose a hypothesis that considers Fermat primes as a criterion for the infinitude of such primes, where Mp represents Mersenne primes. Additionally, we provide an elementary argument supporting the presence of infinitely many primes in the form , as these primes are a subset of primes of the same form x 2 + 1 . Furthermore, we present a basic argument demonstrating the infinity of Mersenne primes. This paper contributes to the understanding of prime numbers and their intriguing relationships with quadratic polynomials and Fermat primes </p>