bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 2‐high airway inflammation in childhood asthma distinguishes a more severe phenotype
Authors: Skov Frederikke R. , Sultan Tamo , Fischer‐Rasmussen Kasper , Chawes Bo L. , Stokholm Jakob , Vahman Nilo , Bønnelykke Klaus , Schoos Ann‐Marie M. 
Published: February 2025

AbstractBackgroundIt remains unclear whether phenotyping of type 2‐high (T2‐high) asthma can distinguish clinical characteristics and lung function trajectories in childhood.ObjectiveTo explore differences between T2‐high and T2‐low asthma from birth to age 18 years.MethodsWe included 47 children with asthma and 165 as a control group from the Copenhagen Prospective Studies on Asthma in Childhood2000 mother–child cohort. T2‐high and T2‐low asthma was defined at age 7 by sensitization to aeroallergens, elevated eosinophilic blood count, and/or elevated fractional nitric oxide. Lung function measurements included whole‐body plethysmography, spirometry, exercise test, cold air provocation, and methacholine challenge. Differences in lung function trajectories and traits were analyzed using linear mixed models, Wilcoxon rank‐sum test, Fisher's exact test, and Quasi‐Poisson regression.ResultsAt age 7 years, 47 had asthma (26 T2‐high, 21 T2‐low). By age 18, 12 (46.2%) with T2‐high had persistent asthma whereas 2 (9.2%) with T2‐low; OR 8.14 [1.57–42.34]. Specific airway resistance (sRaw) was 12.5% higher through childhood in children with T2‐high asthma (estimate 0.53 [0.06; 1.01]); lung function was more reversible (OR 3.37 [1.03–11.00] for spirometry and OR 2.60 [1.17; 5.75] for sRaw), and they had increased airway hyperresponsiveness (AHR) to methacholine (as shown by 41% lower dose required to cause a 20% drop in lung function (estimate −0.70 [−1.18; −0.23])). There was no significant difference in exacerbation rate and other lung function measurements.ConclusionChildhood T2‐high asthma differs from T2‐low asthma in terms of onset, duration, airway resistance, and airway responsiveness.
Toward a Conjunctural Analysis of New York City's Housing Movement
Authors: Krinsky John 
Published: February 2025

ABSTRACTThe work of Antonio Gramsci points the way to the analysis of political conjunctures in ways that are complementary to, but go beyond, those of historical institutionalists. With a focus on the layering of longer‐ and shorter‐term movement and policy dynamics, as well as on the fundamental contradictions that fuel social struggles, the approach is applied here to an analysis of recent housing struggles in New York City. Tracing the historical and organizational roots of contemporary fights over social housing, rent regulation, and evictions, the article argues that broader political backlash has hampered the movement, while the institutional innovations of the movement—and over 80 years of policy—remain resources for a broader and more radical future.
Longitudinal co‐occurrence of adolescent mental health difficulties and democratic citizenship in early adulthood
Authors: Okolikj Martin , Girard Lisa‐Christine 
Published: February 2025

AbstractLittle is known about the link between childhood and adolescent mental health (MH) difficulties and political outcomes in adulthood. This represents an important knowledge gap in understanding early individual‐level factors for future political outcomes. Using the Growing up in Ireland cohort, which follows 8568 children from 9 to 20 years, we examine how different MH difficulties, and their co‐occurrence, are associated with various political outcomes. The results show childhood/adolescent MH difficulties are important predictors of political outcomes at age 20. Adolescents with chronic co‐occurring MH difficulties starting in childhood report a lower interest in politics, lower trust in politicians, are less likely to register to vote, but if voting, are more likely to vote for an antiestablishment party. Adolescents with chronic emotional MH difficulties starting in childhood also report lower trust in politicians, are less likely to register to vote, and report a higher likelihood of voting for an antiestablishment party when voting. Additionally, they evidence lower levels of external political efficacy.
Elderly abuse and neglect in digital media: a 1‐year review of Turkish newspaper reports
Authors: Erdoğan Esra , Bilkay Halil İbrahim 
Published: February 2025

ABSTRACTIntroductionThis study focuses on how news of neglect and abuse about elderly individuals is given in digital media and the perception toward elderly individuals.MethodsEight national newspapers in Turkey were included in the study for the sample. The news texts were obtained from the digital archives of the newspapers and the term ‘elderly’ was selected as the keyword to accurately search the texts.ResultThe researcher analyzed and divided the collected data into the following categories on elder abuse and neglect: the victim's characteristics, data of the person who inflicted neglect and abuse, the incident's nature and consequences, and the negative concepts mentioned in the incident. The content analysis showed that the related statements and information provided by the media were based on negative concepts and included personal data, including visuals, about the victim.ConclusionsThe findings of the study suggest that elderly individuals, who are a disadvantaged group, are highly exposed to neglect and abuse, and most of them have suffered as they live alone and lack support systems. This study indicated that the media has the potential to raise awareness about neglect and abuse inflicted on the elderly, but it should act more diligently and responsibly.
Diminished Interoceptive Accuracy in Attention‐Deficit/Hyperactivity Disorder: A Systematic Review
Authors: M. Bruton Alisha , Levy Laura , Rai Navdeep Kaur , Colgan Dana Dharmakaya , M. Johnstone Jeanette 
Published: February 2025

ABSTRACTInteroception is the perception of one's internal physiological state. Altered interoception may play a role in the pathogenesis of attention‐deficit/hyperactivity disorder (ADHD). We reviewed the literature on interoception and ADHD symptoms (inattention, hyperactivity/impulsivity, executive function, emotional dysregulation) in individuals with and without the disorder. Studies included assessments of interoception and ADHD symptoms in (1) individuals with/without diagnoses of ADHD or (2) the general population. Interoception assessments included objective measures (heartbeat‐tracking test) and self‐report questionnaires. The literature search included the PubMed/MEDLINE, PsychINFO, CINAHL and Scopus databases. A protocol was prospectively registered in the PROSPERO database (CRD #42022351726); the PRISMA guidelines directed reporting. The Newcastle–Ottawa scale was adapted to evaluate study quality. Of 636 articles identified, 17 articles (based on 18 studies) met inclusion criteria. Five studies compared interoception in participants with/without ADHD, and three found that interoception was reduced in participants with ADHD. One study compared interoception between presentations of ADHD, finding no differences. Twelve studies assessed the association of ADHD symptoms and interoception in the general population. Overall, results suggested that interoception is reduced in individuals who reported higher symptoms of inattention, hyperactivity, impulsivity, emotional dysregulation, and executive dysfunction. Studies were of moderate quality; issues included small sample sizes and inadequate reporting. Individuals with ADHD may have decreased interoception compared to individuals without. Interoception is negatively associated with ADHD symptoms in the general population. Interventions focused on improving interoceptive abilities may provide an avenue for ADHD treatment. Future work should consider the role of culture in interoception.
The Fertilization of Synbiotic Systems in the Intensive Culture of Penaeus vannamei
Authors: Pimentel Otávio Augusto Lacerda Ferreira , Wasielesky Wilson , Brito Luis Otavio , Roy Luke Aaron , Romano Nicholas , Krummenauer Dariano 
Published: February 2025

ABSTRACTOver the years, the intensification of shrimp Penaeus vannamei production has brought challenges such as disease outbreaks and increases in the nutrient loading of effluents. To be more environmentally friendly as production systems intensified, it became necessary to create systems with a high degree of biosecurity and toward efficiency in water and land use. Thus, microbial‐based systems, such as the biofloc, were pioneered to support industry growth and market demand for shrimp. Currently, a derivation of biofloc has emerged and is gaining ground in the shrimp industry, which is the synbiotic system. Synbiotic systems are microbially based and are characterized by fertilizing the culture water with vegetable bran (prebiotics) that were processed by fermentation and/or microbial respiration by probiotic microorganisms. The fertilization strategy creates conditions similar to a natural environment by supporting microbial loop development, controlling water quality, and suppressing harmful, and pathogenic microorganisms. The synbiotic system is still new and without standard fertilization protocols, which has leads to dissimilar results between laboratory research and commercial farms. Therefore, this review is focused on describing the different fertilization procedures used in the synbiotic system for P. vannamei intensive culture, the importance of each fertilizer component, as well as the processing strategies. Furthermore, in this study, we seek to demonstrate perspectives and recommend future research topics to better understand the advantages and disadvantages of this production system.
“Can I Speak to the Bossman?” Sources of Stress, Behavioral Adaptations, and Role Incongruency in Female Farmers☆
Authors: Proctor Christina , Hopkins Noah , Reece Chase , Griffeth Lauren Ledbetter 
Published: February 2025

AbstractTraditional gender expectations and societal norms, along with unique occupational and organizational policies, may make it difficult for women to work in the agricultural industry. The purpose of this study is to apply Role Congruity Theory to female farmers' experience of occupational stress, and to explore behavioral adaptations used to cope with working in a male‐dominated occupation in areas where conventional gender norms are more prominent. Structured interviews were conducted with 16 female farm owners and managers and a thematic analysis approach was used to analyze data. Female farmers reported stress associated with gender stereotyping, misogyny, role expectations, and lack of respect. This study found that women are perceived as incongruent with the male‐dominated agricultural sector, and experience prejudice and harassment substantiating Role Congruity Theory. In addition, participants reported behavioral adaptations such as adopting masculine traits, dressing differently, and overworking or overcompensating, which may be contributing to higher stress levels. Women participating in this study took pride in defying expectations and succeeding in a male‐dominated occupation, but more effort should be made to promote diversity and inclusion in the agricultural industry.
Bank Business Model Identification, Evolution and Outcomes: Evidence for South Africa
Authors: Wilson John O. S. , Nguyen Linh , Sobiech Anna , Kgari Lechedzani 
Published: February 2025

ABSTRACTThis paper presents the findings of an investigation of the type, evolution and impacts on performance of bank business models in South Africa. We identify the various business models used by South African banks using data on the monthly balance sheets of commercial banks made available by the South African Reserve Bank between 1993 and 2022. We cluster banks into different business models based on the composition of their balance sheets. Based on these clusters, we identify business models oriented to wholesale and retail funding, as well as to universal, investment and interbank activities. Overall, our clustering exercise returns six distinct business models. We observe large differences in terms of business size, performance and risk profiles across the business models. We also analyse the evolution of business models over time. The results suggest that banks exhibit relatively stable business models, but where transition exists it tends to be between certain business models. Increased risk is associated with a higher probability of banks shifting business models.
Misoprostol administration mimicking a febrile transfusion reaction
Authors: Yurtsever Nalan , Snyder Edward L. 
Published: February 2025

AbstractBackgroundMisoprostol, a synthetic prostaglandin E1 analogue, is widely used in obstetrics for its uterotonic properties. It is known to cause thermogenic side effects, a fact well‐recognized in obstetrics but less familiar in transfusion medicine.Study Design and MethodsData were collected through chart review, including temperature recordings, serologic findings, and blood culture results.ResultsThis case report describes a postpartum temperature spike to 39.2°C in a G1P0 female who received a red cell transfusion shortly after administration of misoprostol. Serologic workup for transfusion reaction showed no abnormalities, and blood cultures of both the patient and donor were negative for growth. Febrile nonhemolytic transfusion reaction (FNHTR) remained in the differential, however, the fever was attributed to misoprostol's thermogenic effect rather than a transfusion reaction.DiscussionIncreased awareness of misoprostol's thermogenic effects in transfusion medicine may improve differential diagnosis, reduce unnecessary testing, and enhance patient satisfaction by avoiding unwarranted concerns regarding transfusion reactions.
Integrated Control of Verbesina encelioides in Common Bean Fields in the Central Rift Valley of Ethiopia
Authors: Fufa Amare , Tessema Taye , Bekeko Zelalem , Mesfin Tewodros 
Published: February 2025

ABSTRACTVerbesina encelioides is known to threaten the performance of crops like common bean in central rift valley of Ethiopia. A field experiment was conducted to investigate the effect of management on V. encelioides and common bean yield components and yield at Adamitulu and Melkassa. A randomized complete block design with four replications and twelve treatments was applied. Treatments included pre and postemergence herbicides (s‐metolachlor, pendimethalin, and sodium acifluorfen + clodinafop propargyl) and hand weeding. The density and biomass of V. encelioides were reduced by up to 94% and 81%, respectively, due to integrated control treatments. Beside the weed‐free plot, the use of s‐metolachlor plus hand weeding and pendimethalin plus hand weeding produced the lowest (3%–10%) weed index. Whereas these integrated controls gave the highest (74%–81%) weed control efficiency. Weed‐free plots yielded the highest grain (3.11 and 2.71 t/ha), followed by s‐metolachlor with two hand weedings (3.00 and 2.63 t/ha), while weedy check (0.49 and 0.45 t/ha) and sole pendimethalin 1.5 l/ha (1.28 and 1.12 t/ha) produced the least grain yield at Melkassa and Adamitulu, respectively. The use of s‐metolachlor plus one‐hand weeding, followed by two‐hand weeding, produced a maximum benefit‐cost ratio of 28.41 and 26.95 and an acceptable maximum marginal rate of return of 5689.06 and 5057.27 ETB, respectively. Thus, it is recommended that smetolachlor be used with one‐hand weeding followed by two‐hand weeding or sodium acifluorfen + clodinafop propargyl at 1 l/ha to achieve effective control, higher yield, and economic benefit in common bean production systems.
Arginine accumulation suppresses heat production during fermentation of the biocontrol fungus
Beauveria bassiana
Authors: Wu Tong , Zhan Fangfang , Zeng Liqiong , Sun Yanli , Fu Shihui , Fang Yu , Lin Xiaochun , Lin Haoyu , Su Jun , Cai Shouping 
Published: February 2025

ABSTRACT

Beauveria bassiana
(
Bb
) is one of the most widely used biocontrol agents, and its products constitute more than one-third of the global market share of fungal insecticides. Solid-state fermentation (SSF) is widely used in the production of
Beauveria bassiana
(
Bb
) because of its economic practicality and high production efficiency. However, the heat generated during fermentation can sharply reduce both the yield and quality of
Bb
, and current industrial methods to mitigate high temperatures during fermentation are inadequate, leading to increased production costs. Thus, exploring the underlying mechanism of how heat is produced by
Bb
is crucial for improving the SSF procedure and yield. This study employed multiomics data analysis of
Bb
during SSF to explore the relationships between fungal fermentation and environmental factors. We found that the heat production period for SSF was 12 hours to 48 hours post-inoculation. To further explore the underlying mechanism during this heating period, we identified 454 temperature-correlated metabolites (TCMs) and 1,994 temperature-correlated genes (TCGs). Annotations of the above TCMs and TCGs revealed significant enrichment in the arginine biosynthesis pathway; specifically, the expression level of glutamine synthetase, a TCG, decreased with fermentation time, whereas the expression levels of the TCGs L-arginine and L–glutamine increased with fermentation time, and glutamine synthetase and L-glutamine in the arginine biosynthesis pathway cycle produced the end product L-arginine. Furthermore, when the substrates of the SSF were treated with exogenous arginine, the temperature peak of the SSF significantly decreased with increasing concentration of exogenously added arginine.

IMPORTANCE

A large amount of experimental evidence from the field has shown that
Bb
is an irreplaceable mature product that protects the health of our agriculture and ecosystem. In addition to high efficiency and host extensiveness, low cost is a critical merit that makes
Bb
products frequently used in the field. However, the growing cost of power and labor in the
Bb
industry, especially the SSF procedure, has significantly increased the price of its products, thus restricting the use of
Bb
in the field. This study not only fills the theoretical knowledge gaps concerning the molecular basis of the interrelationship between
Bb
and the fermentation environment during SSF but also provides an economical and applicable strategy (the addition of arginine to the fermentation media) to further lower the cost and increase the yield of
Bb
during SSF at the industrial level.
Would global warming bring an increase of invertebrate-associated cutaneous invasive fungal infections?
Authors: Kontoyiannis Dimitrios P. , Casadevall Arturo 
Published: February 2025

ABSTRACT

Invasive mold-associated cutaneous disease is a rare but potentially catastrophic consequence of trauma. However, invertebrate bites are not well recognized as a mechanism for the inoculation of fungi into subcutaneous tissue that can also result in severe infections. Invertebrates often carry fungi with human pathogenic potential as part of their microbiome, and bites break the skin, providing a conduit for them to penetrate subcutaneous tissues where the establishment of infection can produce serious skin and soft tissue fungal diseases. In this essay, we review the existing data for invertebrate bite-associated cutaneous invasive fungal infections (IBA-cIFIs) and consider the potential consequences of global warming on their epidemiology. Climate changes will be associated with changes in the range of invertebrates and adaptation of their associated microbes to warmer temperatures. Fungal adaptation to higher temperatures can defeat the mammalian protective barrier and be associated with both more and different IBA-cIFIs.
Study of the probability of resistance to phage infection in a collection of clinical isolates of
P
s
eudomonas aeruginosa
in relation to the presence of Pf phages
Authors: Blasco Lucía , Ibarguren-Quiles Clara , López-Causape Carla , Armán Lucía , Barrio-Pujante Antonio , Bleriot Inés , Pacios Olga , Fernández-García Laura , Ortiz-Cartagena Concha , Cantόn Rafael , Oliver Antonio , Tomás María 
Published: February 2025

ABSTRACT

Pseudomonas aeruginosa
is a bacterial pathogen that is a major cause of lung infections in cystic fibrosis (CF) and other patients. Isolates of
P. aeruginosa
from CF patients commonly carry filamentous phages (Pf phages), which constitute a family of temperate phages known to be related to biofilm production and antibiotic sequestration. In this study, we identified 12 new Pf phage genomes in a collection of clinical isolates of
P. aeruginosa
from CF patients. Study of the anti-phage defense systems in the bacterial isolates revealed the presence of 89 such systems, of which eight were encoded in the Pf phage genomes. Finally, although a weak relation between resistance to phage infection and the number of anti-phage defense systems was detected, it was observed that the phage resistance was related to the presence of Pf phages and the anti-phage defense systems encoded in these phages.

IMPORTANCE

Bacteria harbor a wide range of defense mechanisms to avoid phage infections that hamper the application of phage therapy because they can lead to the rapid acquisition of phage resistance. In this study, eight anti-phage defense systems were found in the genome of 12 Pf phages that were presents in 56% of the CF isolates of
P. aeruginosa
. The high prevalence of these phages underlines the importance of our findings about newly discovered filamentous phages and the role of these phages in resistance to phage infections. Thus, the knowledge of the anti-defense system in the Pf phage genomes could be useful in assessing the possible application of phage therapy to treat an infectious disease.