bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morus alba L. Leaves (WML) Modulate Sweet (TAS1R) and Bitter (TAS2R) Taste in the Studies on Human Receptors – A New Perspective on the Utilization of White Mulberry Leaves in Food Production?
Authors: Przeor Monika , Jokiel Maria 
Published: October 2023

AbstractFrom the nutritional perspective, the main direction of the utilization of white mulberry (Morus alba L.) parts so far has been to produce dietary supplements or functional foods for individuals with diabetes or over-weight. Its leaves are widely known as a valuable source of bioactive compounds responsible for its antioxidant and antidiabetic effects, both in animals and humans. The authors found that processed leaves can also be investigated as potential bitter and/or sweet taste modulators—an important property of new functional foods. The study aimed to validate the inhibitory effect of Morus alba L. on the TAS2R3 and TAS2R13 bitter taste and TSA1R2/TSA1R3 receptors and determine the changes that the conditioning process caused in such receptors. The effect on the receptors was evaluated in specially transfected HEK293T cells, and the inhibition ratio was measured using the calcium release test. Moreover, the stability of phenolics in the simulated intestinal in vitro digestion process was determined. Results showed that the Morus alba leaf extracts were rich in gallic, chlorogenic and caffeic acids together with rutin and quercetin 3-(6-malonyl)-glucoside, while the conditioning process positively affected their amount. Most identified phenolics were reduced during in vitro digestion. In the taste receptors test, it was found that the phytochemicals from conditioned Morus alba leaf extract enhanced sweet taste, together with a reduction of bitter taste receptor activity in some cases. To conclude, the study has found that Morus alba, especially when conditioned for 4 h, seems to be a valuable modulator of taste, which should be considered in future research as a crucial reason for its new utilization.
Urbanisation threats to dairy cattle health: Insights from Greater Bengaluru, India
Authors: Alam Md Shahin , Velayudhan Silpa Mullakkalparambil , Dey Debpriyo Kumar , Adilieme Chiamaka , Malik Pradeep Kumar , Bhatta Raghavendra , König Sven , Schlecht Eva 
Published: October 2023

AbstractComplex urbanisation dynamics, on the one hand, create a high demand for animal products, and on the other hand put enormous pressure on arable land with negative consequences for animal feed production. To explore the impact of accelerated urbanisation on dairy cattle health in urban farming systems, 151 farmers from different parts of the Greater Bengaluru metropolitan area in India were individually interviewed on aspects addressing cattle management and cattle health. In addition, 97 samples of forages from the shores of 10 different lakes, and vegetable leftovers used in cattle feeding were collected for nutritional analysis. Along with the use of cultivated forages, crop residues, and concentrate feed, 47% and 77% of the farmers occasionally or frequently used lake fodder and food leftovers, respectively. Nutritionally, lake fodder corresponded to high-quality pasture vegetation, but 43% of the samples contained toxic heavy metals such as arsenic, cadmium, chromium, and lead above official critical threshold levels. Therefore, lake fodder may affect cows’ health if consumed regularly; however, heavy metal concentrations varied between lakes (P < 0.05), but not between fodder types (P > 0.05). Although 60% of the interviewed farmers believed that their cows were in good health, logit model applications revealed that insufficient drinking water supply and the use of lake fodder negatively impacted cattle health (P < 0.05). While it remains unknown if regular feeding of lake fodder results in heavy metal accumulation in animal products, farmers and farm advisors must address this and other urbanization-related challenges to protect cattle health.Graphical abstract
Amine-Functionalized MWCNTs for the Removal of Mordant Black 11 Dye
Authors: Qazi Raina Aman , Ullah Nabi , Bibi Naheed , Khattak Rozina , Jamila Nargis , Begum Bushra , Aman Nargis , Rahayu Farida , Karami Abdulnasser M. 
Published: October 2023

AbstractIn this study, amine-functionalized MWCNTs (f-MWCNTs) have been investigated as potential material for the removal of Mordant black dye 11 (MBD 11). To evaluate the optimal condition and adsorption capability of the adsorbents (f-MWCNTs), the effect of temperature, pH, adsorbent dosage, and contact time on adsorption rate are examined. The study shows a stronger interaction between the dye and f-MWCNTs. The highest removal efficiency is observed in acidic medium (pH 2) with an initial dye concentration of 50 mg L−1, where 99% of the dye is adsorbed from the medium in 40 min using 0.05 g of f-MWCNTs. Adsorption isotherm and kinetic studies reveal that adsorption occurs by the Langmuir adsorption model and pseudo-second-order adsorption kinetics. According to the thermodynamic parameters, the adsorption exhibits endothermic and spontaneous behavior.
Graphical Abstract
Quantitative evaluation of forest communities and effects of oak wilt in a secondary forest in western Japan
Authors: Yoshioka Takahiko , Okuyama Souta , Kogire Taketo , Taniuchi Ren , Hotta Kana K. , Tochimoto Daisuke , Ishii H. Roaki 
Published: October 2023

AbstractIn Japan, secondary forests associated with agriculture (satoyama) had been maintained traditionally by small-scale clearcutting and short-rotation coppice forestry. After forest management was discontinued due to modernization, shade-intolerant, deciduous trees such as Q. serrata and Q. variabilis have become dominant in many secondary forests of southwestern Japan. In recent years, however, tree death from Japanese oak wilt has become wide-spread. To identify forest communities that will be most affected by oak wilt, we investigated stand structure and species composition in a 64-ha unmanaged secondary forest in Kobe, Japan. We identified three forest communities using cluster analysis of 27 survey plots. We then analyzed and visualized vegetation similarity among the communities using non-metric multidimensional scaling (nMDS). In secondary forests, Pinus densiflora–Rhododendron macrosepalum and Quercus serrata–Quercus variabilis communities, which established after pine wilt were identified. We also found communities dominated by Cryptomeria japonica, a plantation species. We predicted that Quercus serrata–Quercus variabilis communities will experience significant vegetation change after oak wilt and become low-statured, evergreen-deciduous forests. These communities, therefore, should be prioritized for active management by small-scale clear cutting to prevent further spread of oak wilt and subsequent biodiversity decline.
Software is Policy: Electronic Health Record Governance and the Implications of Clinical Standardization
Authors: Brunner Julian , Cannedy Shay , McCoy Matthew , Hamilton Alison B. , Shelton Jeremy 
Published: October 2023

Abstract
Background
Electronic health record (EHR) implementations, whether replacing paper or electronic systems, are major social and organizational transformations. Yet studies of EHR-to-EHR transitions have largely neglected to elucidate accompanying social and organizational changes. One such underexplored change is the standardization of clinical practice in the context of EHR transitions.
The Department of Veterans Affairs (VA) has begun a decade-long process of replacing the approximately 130 separate versions of its homegrown EHR with a single commercial EHR system. This provides an opportunity to explore the standardization of clinical practice amidst an EHR transition.

Objective
To identify, in the context of a large-scale EHR transition, (1) the scope and content of clinical standardization and (2) the anticipated implications of such standardization.

Design
Qualitative study.

Participants
Twenty-nine members of VA councils established for the EHR transition.

Approach
We conducted semi-structured interviews, which were professionally transcribed, and analyzed first using rapid analysis methods, followed by coding and content analysis.

Key Results
Clinical standardization across facilities was a central goal of the EHR transition, encompassing computerized recommendations, order sets, professional roles/permissions, and clinical documentation. The anticipated implications of this standardization include (i) potential efficiency gains, with less duplicated effort across facilities; (ii) expanded bureaucracy; and (iii) increased uniformity, reducing both wanted and unwanted variation in care.

Conclusions
EHR systems shape a wide range of clinical processes, particularly in a large organization like VA with a long history of EHR use. This makes standardization of EHR content a powerful mechanism for standardizing clinical practice itself, which can bring dramatic collateral consequences. Organizations undergoing EHR transitions need to recognize the important role that clinical standardization plays by treating EHR transitions as major organizational transformations in the governance of clinical practice.
Generalized Cramér’s coefficient via f-divergence for contingency tables
Authors: Urasaki Wataru , Nakagawa Tomoyuki , Momozaki Tomotaka , Tomizawa Sadao 
Published: October 2023

AbstractVarious measures in two-way contingency table analysis have been proposed to express the strength of association between row and column variables in contingency tables. Tomizawa et al. (2004) proposed more general measures, including Cramér’s coefficient, using the power-divergence. In this paper, we propose measures using the f-divergence that has a wider class than the power-divergence. Unlike statistical hypothesis tests, these measures provide quantification of the association structure in contingency tables. The contribution of our study is proving that a measure applying a function that satisfies the condition of the f-divergence has desirable properties for measuring the strength of association in contingency tables. With this contribution, we can easily construct a new measure using a divergence that has essential properties for the analyst. For example, we conducted numerical experiments with a measure applying the $$\theta$$
θ
-divergence. Furthermore, we can give further interpretation of the association between the row and column variables in the contingency table, which could not be obtained with the conventional one. We also show a relationship between our proposed measures and the correlation coefficient in a bivariate normal distribution of latent variables in the contingency tables.
Efficacy and safety of metformin during pregnancy: an update
Authors: Paschou Stavroula A. , Shalit Almog , Gerontiti Eleni , Athanasiadou Kleoniki I. , Kalampokas Theodoros , Psaltopoulou Theodora , Lambrinoudaki Irene , Anastasiou Eleni , Wolffenbuttel Bruce H. R. , Goulis Dimitrios G. 
Published: October 2023

AbstractDuring the last decades, gestational diabetes mellitus (GDM) prevalence has been on the rise. While insulin remains the gold standard treatment for GDM, metformin use during pregnancy is controversial. This review aimed to comprehensively assess the available data on the efficacy and safety of metformin during pregnancy, both for the mother and the offspring. Metformin has been validated for maternal efficacy and safety, achieving comparable glycemic control with insulin. Additionally, it reduces maternal weight gain and possibly the occurrence of hypertensive disorders. During the early neonatal period, metformin administration does not increase the risk of congenital anomalies or other major adverse effects, including lower APGAR score at 5 min, neonatal intensive care unit admissions, and respiratory distress syndrome. Several studies have demonstrated a reduction in neonatal hypoglycemia. Metformin has been associated with an increase in preterm births and lower birth weight, although this effect is controversial and depends on the indication for which it was administered. Evidence indicates possible altered fetal programming and predisposition to childhood obesity and metabolic syndrome during adulthood after use of metformin in pregnancy. With critical questions still requiring a final verdict, ongoing research on the field must be conducted.
Towards statistical analysis of predictive parameters in competitive speed climbing
Authors: Pandurevic Dominik , Sutor Alexander , Hochradel Klaus 
Published: October 2023

AbstractCompetitive sport climbing progressed massively within the last quarter century. Development of technology enabling qualitative and quantitative analysis is required to withstand the challenges for athletes and trainers. This paper deals with the statistical study of a data set generated by the application of several image processing algorithms and neural networks on competition recordings. Therefore, calculated parameters are combined with random variables for the implementation of a linear mixed effect model. The resulting model enables the prediction of the end time of different athletes and the determination of its correlation with the input variables. Furthermore, analysis of velocity and path of the centre of gravity in different wall sections is done for all available speed climbing athletes. The observed data set consists of 297 runs in total divided into two subsets of 202 observations of 47 male and 95 of 25 female athletes. Among others, the statistical model was used for the validation of the measured parameters and the review and impact of proven techniques like the Tomoa skip in the start section. Likewise interesting is the high influence of the parameters, measured especially in the middle section of the wall, on the end time.
Data-driven approaches for sustainable agri-food: coping with sustainability and interpretability
Authors: Tomasiello Stefania , Uzair Muhammad , Liu Yang , Loit Evelin 
Published: October 2023

AbstractMotivated by the increasing interest in machine learning algorithms for data-driven applications in agri-food addressing sustainability issues and by the ongoing discussion on the interpretability and sustainability of such algorithms, we compare congruently the performance of some state-of-the-art techniques and a new version (here proposed for the first time) of Co-Active Neuro-Fuzzy Inference System, equipped with fractional regularization (CANFIS-T for short). To this end, we consider two case studies retrieved from the literature and dealing with two approaches for sustainability development, i.e. ex-ante Life Cycle Assessment and Supply Chain Operations Reference in the agri-food context. Such approaches are set in a data-driven framework and completed by the above-mentioned machine learning techniques. The state-of-the-art techniques from the relevant literature are the ensemble ANFIS, Radial Basis Function Network and Decision Tree. The techniques are compared from the computational, interpretability and energy standpoints. From a formal perspective, we prove what negatively affects the accuracy of ensemble ANFIS. On the basis of the performed experiments, we notice that except for the ensemble ANFIS, all the approaches can be regarded as sustainable, with energy savings over 99%, while only CANFIS-T keeps both good accuracy and interpretability (with up to 4 rules) when the number of input and output variables gets large.
Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery
Authors: Moyo Phanankosi , Invernizzi Luke , Mianda Sephora M. , Rudolph Wiehan , Andayi Warren A. , Wang Mingxun , Crouch Neil R. , Maharaj Vinesh J. 
Published: October 2023

AbstractThe antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development of new antimalarial drugs. Plants represent a viable alternative source for the discovery of unique potential antiplasmodial chemical scaffolds. To expedite the discovery of new antiplasmodial compounds from plants, the aim of this study was to use phylogenetic analysis to identify higher plant orders and families that can be rationally prioritised for antimalarial drug discovery. We queried the PubMed database for publications documenting antiplasmodial properties of natural compounds isolated from higher plants. Thereafter, we manually collated compounds reported along with plant species of origin and relevant pharmacological data. We systematically assigned antiplasmodial-associated plant species into recognised families and orders, and then computed the resistance index, selectivity index and physicochemical properties of the compounds from each taxonomic group. Correlating the generated phylogenetic trees and the biological data of each clade allowed for the identification of 3 ‘hot’ plant orders and families. The top 3 ranked plant orders were the (i) Caryophyllales, (ii) Buxales, and (iii) Chloranthales. The top 3 ranked plant families were the (i) Ancistrocladaceae, (ii) Simaroubaceae, and (iii) Buxaceae. The highly active natural compounds (IC50 ≤ 1 µM) isolated from these plant orders and families are structurally unique to the ‘legacy’ antimalarial drugs. Our study was able to identify the most prolific taxa at order and family rank that we propose be prioritised in the search for potent, safe and drug-like antimalarial molecules.
Revisiting the Definition of Bullying in the Context of Higher Education
Authors: Tay Emmanuel Mensah Kormla 
Published: October 2023

AbstractThis study used a qualitative method to verify the interpersonal interactions that students consider to constitute bullying in higher education. The data came from 58 semi-structured interviews with students and administrators from two public universities in Ghana and one in Norway to show how national differences influence bullying. The broad range of behaviours identified highlighted themes like “inconveniencing”, “exclusion”, “intimidation”, “shaming”, “booing, gossiping, and teasing”, “sexual harassment and unwanted touching, fondling, and kissing”, and “ignoring or facing hostile reactions”. The study found that behaviours students identified as bullying are subtler and are intertwined with everyday interpersonal encounters, making identifying, reporting, and redressing them elusive. Students identified their limited awareness of anti-bullying structures, insufficient deterrence due to a lack of transparency in rule implementation, and noncommitment by authorities as favouring bullying. The study suggests the use of communication about behaviour expectations and a commitment to creating consciousness against bullying to ensure a positive psychosocial learning environment.
Active Vibration Control of a Rotating Machine with Voltage-Driven Electrodynamic Actuators Between Machine Feet and Steel Frame Foundation Under Multiple Base Excitations
Authors: Werner Ulrich 
Published: October 2023

Abstract
Purpose
In the paper, a theoretical analysis—based on a 2D multibody model—is presented regarding active vibration control of a rotating machine with voltage-driven electrodynamic actuators between machine feet and steel frame foundation under multiple base excitations.

Methods
Mathematical formulations are derived in the time domain and then transferred into the Laplace domain, where a state space formulation is used to describe the controlled vibration system. With this mathematical formulations, it is possible to analyze separately the two different kinds of actuator forces—the actuator forces, caused by the motion-induced voltage and the actuator forces caused by the control system—and their influence on the vibration behavior. Afterward, the mathematical formulations are transferred into the Fourier domain, for considering harmonic excitations of the base. Also a numerical example is presented, where different cases regarding machine mounting and operation conditions are investigated and compared to each other.

Results
It could be clearly demonstrated that with the presented control system, most of the resonance peaks in the frequency responses could be strongly damped.

Conclusions
With the presented mathematical formulations, the controlled vibration system can be well described, considering separately the two different kinds of electrodynamic actuator forces and their influence.
A Behavioral Account of Opportunistic Diversification: Evidence from Non-Real-Estate Firms’ Investment in Real Estate
Authors: Shi Wei , Cai Wenjing , Wajda Dennis , Jiang Fuxiu 
Published: October 2023

AbstractThis study provides a behavioral account of opportunistic diversification. We argue that top executives’ social comparison with peer firms based on business segment performance can lead them to increase their investments in high-profitability new businesses (i.e., opportunistic diversification). Specifically, when the performance of a firm's main business relative to its peer firms’ high-profitability business segment falls short of their aspirations, the firm's top executives will engage in problemistic search and subsequently increase opportunistic diversification. This effect is stronger when the firm is similar to peer firms along key firm characteristics and when top executives of the firm are underpaid. Although opportunistic diversification helps improve a firm's short-term accounting performance, it may weaken its long-term performance. Using Chinese non-real-estate firms’ diversification investment in real estate as our empirical context, we find support for our arguments.
After the Gang: Desistance, Violence and Occupational Options in Nicaragua
Authors: Rodgers Dennis 
Published: October 2023

AbstractGangs are widely considered major contributors to the high levels of violence afflicting Latin America, including in particular Central America. At the same time, however, the vast majority of individuals who join a gang will also leave it and, it is assumed, become less violent. Having said this, the mechanisms underlying this ‘desistance’ process are not well understood, and nor are the determinants of individuals’ post-gang trajectories, partly because gang desistance tends to be seen as an event rather than a process. Drawing on long-term ethnographic research carried out in barrio Luis Fanor Hernández, a poor neighbourhood in Nicaragua's capital city Managua, and more specifically a set of ‘archetypal’ gang member life histories that illustrate the occupational options open to former gang members, this article offers a longitudinal perspective on desistance and its consequences, with specific reference to the determinants of individuals’ continued engagement with violence (or not).
Xenotransplantation Clinical Trials and Equitable Patient Selection
Authors: Bobier Christopher , Rodger Daniel 
Published: October 2023

AbstractXenotransplant patient selection recommendations restrict clinical trial participation to seriously ill patients for whom alternative therapies are unavailable or who will likely die while waiting for an allotransplant. Despite a scholarly consensus that this is advisable, we propose to examine this restriction. We offer three lines of criticism: (1) The risk–benefit calculation may well be unfavorable for seriously ill patients and society; (2) the guidelines conflict with criteria for equitable patient selection; and (3) the selection of seriously ill patients may compromise informed consent. We conclude by highlighting how the current guidance reveals a tension between the societal values of justice and beneficence.