bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal cAncer and CrohN's DIsease study (CANDID): An international multicentre retrospective audit
Authors: Garoufalia Zoe , Emile Sameh Hany , Dourado Justin , Boutros Marylise , Brady Richard , Celentano Valerio , Davies Justin , Fleshner Phillip R. , Gefen Rachel , Holubar Stefan D. , Horesh Nir , El‐Hussuna Alaa , Keller Deborah , Lightner Amy , Pellino Gianluca , Shawki Sherief , Siakavellas Spyros , Spinelli Antonino , Warusavitarne Janindra , Wexner Steven D. 
Published: January 2025

AbstractBackgroundInflammatory bowel disease (IBD) affects more than 10 million people worldwide. Men and women are equally affected by Crohn's disease (CD). It has been shown that patients with CD are at an increased risk of a colorectal cancer (CRC) diagnosis and CRC‐related mortality. During the last two decades, biological therapies have revolutionized the treatment of CD. There are no current studies investigating the prevalence of CRC in patients with CD in the era of biological therapy and the possible features of patients with CD who are at high risk of developing CRC.AimWe aim to assess the prevalence of CRC, risk factors and profile of CRC in patients with CD receiving biological treatment compared with those who are not under biological therapy and the impact of CD‐associated colorectal strictures on CRC development. The study hypothesis is that the use of biological therapy in the control of CD activity may decrease the risk of developing CRC.Study design and settingAn international, retrospective, snapshot of the prevalence of CRC in patients with CD, reported according to the SPIRIT guidelines. The study will involve centres that hold regular IBD multidisciplinary team meetings and have both IBD colorectal surgeons and gastroenterologists. Each participating centre will provide a local consultant lead and a local trainee lead. Data will be collected within a 2‐year recruitment period (January 2017–January 2019).Study populationAdult patients who presented with CD during the study period. Patients with an incidental diagnosis of CD during evaluation for CRC will be excluded.Statistical planBaseline patient characteristics will be summarized using the appropriate descriptive statistics. Univariable, multivariable and Cox regression models will be used to identify factors significantly associated with CRC. For noncontinuous variables a comparison between the subgroups will be carried out using the chi‐square test corrected by Fisher's exact test if appropriate. A p‐value of <0.05 will be considered statistically significant.Data storageData will be stored on a secured server, pin‐code protected according to the local data management agreement.
Temperate forests of high conservation value are successfully identified by satellite and LiDAR data fusion
Authors: Assmann Jakob J. , Pedersen Pil B. M. , Moeslund Jesper E. , Senf Cornelius , Treier Urs A. , Corcoran Derek , Koma Zsófia , Nord‐Larsen Thomas , Normand Signe 
Published: January 2025

AbstractForest ecosystems will play a critical role in achieving policy targets for biodiversity and conservation, such as those set out in the EU Biodiversity strategy for 2030. However, practitioners need to know where forests of high conservation value are to make the best‐informed decisions about which forests to prioritize. Here, we combine airborne LiDAR (airborne laser scanning/ALS), optical satellite imagery, and gridded datasets on soil and water availability with machine learning models to predict forests' conservation value across Denmark. We then use change‐detection algorithms to identify forests that had been disturbed since the collection of the LiDAR data to produce up‐to‐date estimates for the year 2020. Our models reached a high predictive capacity (82% accuracy) and suggested that 1982 km2 (~31%) of Denmark's forests were of potential high conservation value. Our study demonstrates the utility of data fusion approaches to identify forest areas of high value for conservation at fine spatial resolutions (~10–100 m) and nationwide extents. However, uncertainties remain in our approach. Hence, our findings should be used to guide field‐based assessments to confirm the in situ conservation value of the forests. Only in combination with such in situ data will approaches like ours enable decision makers to better protect forest biodiversity.
Outcomes of Liver Transplant for Hepatic Epithelioid Hemangioendothelioma
Authors: Larson Emily L. , Ciftci Yusuf , Jenkins Reed T. , Zhou Alice L. , Ruck Jessica M. , Philosophe Benjamin 
Published: January 2025

ABSTRACTIntroductionHepatic epithelioid hemangioendothelioma (HEH) is a rare indication of liver transplant with limited evidence.MethodsAdult recipients undergoing first‐time liver‐only transplant from 2002 to 2021 in the United States were identified using the UNOS/OPTN database. We compared post‐transplant outcomes of recipients receiving liver transplant for HEH versus other diagnoses. Survival was visualized using Kaplan‐Meier curves and compared using log‐rank test and multivariable Cox regression. Propensity score matching for recipient age, sex, and MELD was performed, with baseline characteristics and survival compared between groups.ResultsOf 111 558 liver transplant recipients identified, 121 (0.1%) underwent transplant for HEH. Donors to HEH recipients were more often living donors. Recipients with HEH were younger, more likely to be female, and had lower BMI. Recipients with HEH had higher albumin, lower bilirubin, lower INR, and lower serum creatinine, as well as lower MELD scores and rates of ascites and encephalopathy. Similar post‐transplant survival was observed for recipients with HEH (16.6 [lower 95% CI 14.9] years) and non‐HEH diagnoses (13.8 [95% CI 13.6–13.9] years, log‐rank p = 0.28), even after adjusting for baseline donor and recipient characteristics (aHR 1.28 [95% CI 0.94–1.74], p = 0.12). The propensity score matched cohort also had similar post‐LT survival.ConclusionsThis national study represents the largest known report on liver transplant for HEH. The survival of recipients with HEH was similar to other etiologies, supporting the use of liver transplantation (LT) in advanced HEH.
Clinical Outcomes and Safety Profiles of Generic Versus Brand‐Name Clopidogrel in Patients Following Coronary Artery Stent Placement
Authors: Chia Chin‐Yuan , Hsiao Fu‐Chih , Hsu Tzyy‐Jer , Tung Ying‐Chang , Lin Chia‐Pin , Chu Pao‐Hsien 
Published: January 2025

ABSTRACTCoronary artery disease remains a significant global health issue and is a leading cause of mortality. Dual antiplatelet therapy, including clopidogrel, is essential for preventing stent thrombosis after coronary artery stenting. This study assessed the comparative efficacy and safety of generic versus brand‐name clopidogrel in a large Taiwanese cohort. A retrospective cohort study was conducted using the National Health Insurance database, identifying patients who underwent coronary stenting and received either generic or brand‐name clopidogrel between January 1, 2008, and December 31, 2021. Propensity score matching was employed to balance baseline characteristics. The primary efficacy outcome was a composite of myocardial infarction, ischemic stroke, or cardiovascular death over a two‐year follow‐up. The primary safety outcome was major bleeding requiring hospitalization. A total of 211,509 patients were included, of which 2686 received generic clopidogrel and 208,823 received brand‐name clopidogrel. After matching, 2686 patients from each group were analyzed. The hazard ratio for the primary efficacy outcome was 0.92 (95% confidence interval: 0.78–1.10), indicating no significant difference between the two groups. The subdistribution hazard ratio for the primary safety outcome was 1.06 (95% confidence interval: 0.84–1.33), suggesting no significant difference in bleeding risk. Subgroup analyses showed consistent results across various patient demographics and clinical conditions. In conclusion, among patients undergoing coronary stenting, the risks of ischemic and bleeding events were comparable between those receiving generic and brand‐name clopidogrel.
Paving the Way towards Green Development: Impact of the Belt and Road Initiative on Electrification in Participating Countries
Authors: Zhou Mao , Wu Jiahui , Wang Xia , Liu Chang 
Published: January 2025

AbstractElectrification is crucial for achieving global net zero emissions and reducing energy poverty, particularly in developing countries involved in the Belt and Road Initiative (BRI). This study uses the difference‐in‐differences method to examine the BRI's impact on electrification levels in 118 countries from 2009 to 2020. Its findings indicate that the BRI increased electrification in BRI countries by approximately 1 percent compared with non‐BRI countries. This increase was driven primarily by enhanced trade and investments, which facilitated imports of power equipment and supported China‐backed power‐plant projects. The BRI's impact was more pronounced in Maritime Silk Road countries, high‐income nations, and those with favorable business environments. Although the BRI promoted both renewable and nonrenewable power equipment imports, it primarily favored nonrenewable infrastructure investments. Given China's expertise in clean energy, there remains untapped potential for the BRI to prioritize renewable energy integration, fostering a sustainable and low‐carbon future.
Young Adult Perspectives on Treatment Engagement and Family Communication During Psychosis
Authors: Ipekci Bediha , Thibeau Heather , Gibbs Jada , Barnard Emily , Kline Emily R. 
Published: January 2025

ABSTRACTBackgroundFostering positive relationships with mental health professionals and involving family in treatment can reduce untreated psychosis duration and prevent dropout.AimsThe present study explores the experiences of young adults with psychosis as they engage in mental health treatment and communicate with family caregivers. Describing their lived experiences would inform the clinical engagement process and pathways to clinical outcomes.MethodsWe conducted qualitative interviews with 12 individuals who have been diagnosed with a psychotic disorder within the past 5 years.ResultsMajor themes include (1) Facilitators and barriers to robust treatment engagement, (2) Family involvement with treatment and communication about psychosis, and (3) Determinants of family communication quality.DiscussionThese themes highlight the pivotal role of the therapeutic alliance, measured family involvement, and positive family communication in facilitating treatment engagement. We discuss these qualitative findings in the context of patient‐centered care and family interventions.
Anisotropy of the Orientation Selectivity in the Visual Cortex Area 18 of Cats Reared Under Normal and Altered Visual Experience
Authors: Merkulyeva N. , Lyakhovetskii V. , Mikhalkin А. 
Published: January 2025

ABSTRACTThe “oblique effect” refers to the reduced visual performance for stimuli presented at oblique orientations compared to those at cardinal orientations. In the cortex, neurons that respond to specific orientations are organized into orientation columns. This raises the question: Are the orientation signals in the iso‐orientation columns associated with cardinal orientations the same as those in the iso‐orientation columns associated with oblique orientations, and is this signal influenced by experience? To explore this, iso‐orientation columns in visual area 18 were examined using optical imaging techniques. Kittens were raised under either standard or modified conditions, including total darkness or rhythmic light stimulation through one or both eyes, which could potentially disrupt the orientation tuning of visual neurons. A signal profile around the pinwheel center was calculated to assess the distribution of the orientation signal within the hypercolumn. This profile exhibits a sinusoidal pattern with identifiable minima and maxima. To emphasize that these amplitude variations are localized within a specific circle rather than throughout the entire optical map, we used the terms “local minima” and “local maxima.” The number of local maxima in areas corresponding to oblique orientations was similar to those in regions associated with vertical orientations. The highest number of local maxima was found in horizontal iso‐orientation columns, indicating a “horizontal bias.” This finding may be related to the postnatal development of sensory–sensory and sensory–motor integrations involving the visual system. We propose that the data presented should be incorporated into mathematical models of visual cortex activity, as well as vision itself.
Characteristics of adult children with autism and caregiver burden
Authors: Marsack‐Topolewski Christina N. , Wang Fei , Samuel Preethy Sarah 
Published: January 2025

AbstractObjectiveThis study's purpose was to determine if parental perceptions of their adult children's communication, behavior, and socialization skills were significantly associated with caregiver burden after controlling for income and age of the child with an autism spectrum disorder (ASD).BackgroundMost parents provide support to their children with ASD across the lifespan. This study focused on informing knowledge gaps in caregiving literature in determining which ASD characteristics contribute to caregiver burden.MethodData gathered from 320 parents of adult children with ASD were used to conduct regression analysis to understand how caregiver burden was influenced by three core characteristics of ASD while controlling for age and income.ResultsBehavior of the adult child predicted caregiver burden and its four types, whereas communication predicted time dependence burden. Caregivers with higher income reported less total and developmental burden and those with older children reported less time dependence burden.ConclusionFindings demonstrate that behavioral challenges of an adult child with ASD contribute significantly to the parental perceptions of caregiver burden, warranting support for aging parents.ImplicationsProfessionals should be encouraged and supported to provide services to parents who support their adult children with decreased communication abilities, behavioral, and/or socialization challenges daily.
Thermal Damage Impact on Negative Poisson's Ratio of Granite Under Brazilian Tensile Loading
Authors: Wang Tianzuo , Wang Jisha , Xue Fei , Huang Xiaolin , Lin Zhongqin , Liang Zhu 
Published: January 2025

ABSTRACTThis study investigates the effects of thermal damage on the tensile behavior of granite during Brazilian splitting tests, focusing on the negative Poisson's ratio (NPR) effect. Using digital image correlation and acoustic emission techniques, the research reveals that increasing thermal damage from 25°C to 800°C reduces granite tensile strength by up to 85.7% and induces a brittle‐to‐ductile transition. The NPR effect emerges, intensifies, and subsequently disappears as temperature increases, significantly altering stress distribution and deformation patterns. Local contraction zones created by the NPR effect can lead to overestimation of tensile strength in thermally damaged rock. Acoustic emission monitoring demonstrates a strong correlation between the NPR effect and microcrack development. These findings advance the understanding of rock mechanical behavior under thermal damage and provide practical insights for tensile strength evaluation in high‐temperature geological settings, such as deep underground energy development and nuclear waste disposal.
Social‐Ecological Dynamics of Sustainable Small‐Scale Fisheries Management in the Sundarbans Mangrove Forest Region, Bangladesh
Authors: Karim Md Rezaul , Ahasan S. M. Nayem , Ashik Ur Rahman Md 
Published: January 2025

ABSTRACTWe employed a social‐ecological systems (SES) framework to investigate the interplay of social and ecological factors influencing the sustainable management of common pool resources, the Sundarbans mangrove forest region in Bangladesh as a case study. Through qualitative and quantitative analyses, we identified positive and negative correlations between dimensions of the SES. Four positive and two negative correlations between dimensions of social systems and ecological systems highlighted the interconnectedness of dimensions in the SES framework. Our study only considered spatial variation across the four SES dimensions, which revealed distinct management practices within the region. Our findings underscored the importance of tailored management strategies to address specific SES dimensions. Enhanced stakeholder participation and institutional frameworks could bolster governance systems and actor capacity, while interventions targeting ecosystem health and species populations may improve sustainable resource systems and resource unit capacity. Our findings provide insights for policymakers and practitioners who seek to promote the sustainability of small‐scale fisheries within SES contexts.
Impact of Glaciers on Trophic Dynamics and Polyunsaturated Fat Accumulation in Southern Greenland Fjord Ecosystems
Authors: Saboret Grégoire , Moccetti Coralie , Wassenaar Leonard I. , Matthews Blake , Aquino Norberto Jr. , Janssen David J. , Brodersen Jakob , Schubert Carsten J. 
Published: January 2025

ABSTRACTThe primary production of fjords across the Arctic and Subarctic is undergoing significant transformations due to the climatically driven retreat of glaciers and ice sheets. However, the implications of these changes for upper trophic levels remain largely unknown. In this study, we employ both bulk and compound‐specific stable isotope analyses to investigate how shifts at the base of fjord food webs impact the carbon and energy sources of consumers. Focusing on two rapidly changing fjords in Southern Greenland, we used the migratory Arctic char as an indicator species, sampling populations along environmental gradients within the fjords, building upon the assumption that char populations feed primarily close to their natal stream, thereby integrating a dietary gradient. Our analysis of bulk stable isotopes in Arctic char tissue confirmed this premise, revealing a consistent change in resource use from the outer to the inner fjord, which nonetheless served as preferred feeding grounds. Essential amino acid analysis further indicated shifts in carbon and nitrogen sources, consistent with changes in nutrient use near glacier inputs characterized by low turbidity and high iron levels. Notably, these changes in the source of primary production were associated with shifts in trophic positions and the transfer of polyunsaturated fatty acids, with Arctic char in glacier‐influenced inner fjords feeding at lower trophic level (size‐corrected) and accumulating higher levels of high‐quality docosahexaenoic acid (DHA). These findings highlight the usefulness of new analytical tools in revealing that glacial retreat can substantially alter food web dynamics, enhancing both carbon flow and the nutritional quality of fish in fjord ecosystems. The two Southern Greenland fjords studied could represent the future of other fjords, where retreating glaciers become land‐terminating and glacial inputs decrease. Our study underscores the critical role of glacier dynamics in affecting high‐level consumers, such as salmonids, with implications for fjords globally.
Erenumab in a patient with persistent headaches after subarachnoid hemorrhage: A case report of an effective treatment
Authors: Gandhi Ajay , Quinoa Travis R. , Geller Eric , Khandelwal Priyank , Agarwalla Pankaj K. 
Published: January 2025

AbstractA patient with persistent refractory headaches from aneurysmal subarachnoid hemorrhage was treated with monthly erenumab injections, a monoclonal antibody to the calcitonin gene–related peptide (CGRP) receptor. These injections decreased the frequency and severity of the patient's debilitating headaches from daily to once or twice per month with positive improvement in function and quality of life. To our knowledge, this is the first reported case in the literature of a patient with persistent post‐subarachnoid hemorrhage headache that was successfully treated with an antibody against the CGRP receptor. This case report highlights the role of CGRP in post‐subarachnoid hemorrhage headaches and the potential role for CGRP pathway‐based therapies as an effective treatment.
Preparation and corrosion resistance to cathode materials for lithium‐ion batteries of CA6 foam ceramics
Authors: Yin Bo , Wang Hailu , Li Yuanbing , Fan Changlong , Li Shujing , Xu Xin 
Published: January 2025

AbstractCA6 foam ceramics (CA6‐FCs) with CA6 as the main crystalline phase were prepared by adding CA6 powder through gel casting process, which reduced the severe shrinkage in the reaction synthesis process of CA6. This simple preparation process can realize the industrial production of CA6‐FCs. The linear change and physical properties of CA6‐FCs can be controlled by adjusting the additional amount of CA6 powder and the solid content of the slurry. The corrosion resistance of CA6‐FCs is better than that of the current mainstream mullite thermal insulation materials in lithium‐ion battery cathode materials. Through the simple process of this study, on the basis of industrial production, CA6‐FCs can replace mullite lightweight thermal insulation materials to improve the alkali corrosion resistance, service life, and maintain production safety of kiln lining.
Supply Chain Digitalization and Agility: How Does Firm Innovation Matter in Companies?
Authors: Wang Michael , Hill Alex , Liu Yang , Hwang Ki‐Soon , Lim Ming K. 
Published: January 2025

ABSTRACTThis study investigates the impact of supply chain digitalization on agility through the lens of innovation within firms. Employing a resource‐based view and dynamic capabilities approach, we analyze the relationship between supply chain digitalization and agility. This exploration is essential for fostering an agile supply chain capable of addressing challenges post COVID‐19. The empirical data were gathered through a survey administered in the Emirates. Factor analysis was performed to validate the measurement models and structural equation modeling techniques were employed to test the hypotheses. Further, the study analyses the mediating role of firm innovation between digitalization and supply chain agility within companies. The findings suggest that firm innovation serves as a significant mediator. Moreover, a multigroup analysis was conducted to examine the moderating effects in the research models, revealing that firm innovation plays a pivotal role in elucidating the mechanism between supply chain digitalization and agility. This study offers valuable insights into supply chain agility and resilience post COVID‐19 and makes a significant contribution to the literature on supply chain digitalization.