bluuebunny/crossref_metadata_2025_split huggingface dataset:
A QSAR and Pharmacophore Survey on Tyrosine Kinase Inhibitors with
Effect on Epidermal Growth Factor Receptor
Authors: Hajiagha Bozorgi Atefeh , Samadi Fatemeh 
Published: December 2023

Background::
Tyrosine kinases are of great importance nowadays in cancer treatment. As
designing new inhibitors with more potency is an optimal goal of pharmaceutical companies, using
previous improvements in this area would be beneficial. One of the most popular and widely used
methods is creating a QSAR model. Another useful way is to build a pharmacophoric map to address
important features of inhibitors.

Methods::
Upon this, a large dataset of molecules was applied to create a QSAR model for the prediction
of the inhibitory activity of molecules against the epidermal growth factor receptor. Using
MOE software, molecular descriptors were calculated in 3d, and a model was built.

Results::
9 descriptors were selected, which describe the energy, shape, and hydrophobicity of the
molecules. A pharmacophoric map was also created, and 3 important features were selected: Hydrophobic
areas, H-bond acceptor regions, and Aromatic moieties.

Conclusion::
These findings proved the results obtained result from the QSAR model.
Intranasal Delivery of Perillyl Alcohol (NEO100) as a New Treatment
Strategy for Glioma
Authors: Schönthal Axel H. , Thome Julio , de Lima Daniela C. , Chen Thomas C. , da Fonseca Clovis O. 
Published: December 2023

Background:
Perillyl alcohol (POH) is a naturally occurring monoterpene that is being
developed as an intranasally delivered agent for the treatment of brain-localized malignancies.
Clinical trials with glioma patients in Brazil have yielded preliminary evidence that this approach
might be able to achieve therapeutic activity and result in prolonged survival of patients.

Methods:
NEO100, a highly pure, current good manufacturing practice-produced version of
POH, is being evaluated in a Phase I/IIa clinical trial with recurrent glioblastoma patients in the
United States. Patients self-administer POH/NEO100 as a mist with a nasal mask over the course
of 15 minutes, four times a day, every day.

Results:
The treatment regimen is well tolerated, even if maintained over several years. It correlated with improved survival when compared to historical controls.

Conclusion:
There is human data demonstrating that this novel approach could become useful for the treatment of malignant glioma.

Clinical Trial Registration Number::
NCT02704858
Comparative Analysis of Chemical Composition and Antibacterial Activities
of Essential Oils from Two Ocimum Species
Authors: Rokonuzzaman Md. , Rahman Atiqur , Reza Abu , Liza Nilufar Yasmin , Okay Sezer , Mostofa Jamal Mohammad Abu Hena , Demirtas Ibrahim 
Published: December 2023

Background:
The species of the genus Ocimum has been used since ancient times in
the Indian subcontinent to cure various illnesses. Essential oil from Ocimum species has antimicrobial activity.

Objective:
The main objective of this study was to extract essential oils from different parts of
two Ocimum species and test their antimicrobial activity

Methods:
Hydrodistillation was used to extract essential oils from various parts of two basil
species, CG_MS was used to identify the chemical compounds, and disk diffusion method was
used to assess their antimicrobial activity.

Results:
A total of sixty-seven chemical compounds from Ocimum sanctum L. and Ocimum gratissimum L. were identified using GC-MS. Among them, eugenol (1.00-27.66%), methyl eugenol
(0.78-28.52%), β-elemene (5.10-20.98%), caryophyllene (0.94-43.18%), caryophyllene oxide
(1.1-10.81%), palmitic acid methyl ester (3.20-21.38%), oleic acid methyl ester (2.91-40.7%) and
linoleic acid methyl ester (1.55-74.71%) comprised the majority of the makeup of essential oils,
due to diverse plant species and body sections, the percentage differed significantly. The essential
oils contained monoterpenes, sesquiterpenes, and aldehydes/ketonic derivatives in the flower and
leaf parts of O. sanctum and the leaf part of O. gratissimum. The essential oils of these Ocimum
species showed good antibacterial activities against the bacteria, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and
Enterococcus faecalis with inhibition zones ranging from 10-36 mm.

Conclusion:
These two species of Ocimum showed significant variation in chemical composition and antibacterial activity.
Organic Electrosynthesis: A Promising Green Tool in Solving Key Steps
for the Total Synthesis of Complex Natural Products
Authors: Bandyopadhyay Ayan , Sarkar Rajib 
Published: December 2023

Abstract:
Electro-organic synthesis, an atom-efficient, sustainable, mild process, permits an ecofriendly
and elegant green path to synthesize structurally complex, still valuable molecules, avoiding
the use of conventional harsh oxidizing and reducing agents and long-route reaction protocols. Being
one of the oldest forms of reaction setups in a laboratory, it deals with fundamental redox chemistry
through the direct application of electrical potential. Here flow of electrons acts as an oxidizing agent
at the anode at the same time reducing agent at the cathode, depending upon the requirement of the
reaction. Simultaneously, it minimizes the generation of reagent waste during the reaction. However,
electrifying organic synthesis plays more than preventing the waste footprint. This technology provides
an alternative roadmap through nonclassical bond disconnections to access desired target molecules
by cutting down a number of steps with the formation of apparently looking difficult bonds
with excellent regio-, chemo-and stereoselectivity. Hence, it emerges as an alternative and attractive
technique for the contemporary synthetic communities. Consequently, in recent years, multiple milestones
have been achieved in the electro-organic synthesis of fascinating natural products through
oxidative C-C bond formation, C-H/N-H functionalization, very rare oxidative N-N dimerization,
RCDA dimerization, etc. Thus, synthesis of extremely complex natural products through finding new
electro-synthetic route as a key methodology have become one of the alluring synthetic targets to
synthetic chemists because of their versatile utilities in medicine, agriculture, food, and cosmetic
industry. This review presents advances in electrochemistry in the total synthesis of 20 complex natural
products reported since 2013. Enabling synthetic steps are analyzed alongside innate advantages
as well as future prospects are speculated.
Determining Anti-Acne Potential of Azadirachta Indica Leaf Powder,
Herbal Hydrogel using S. Aureus Growth Inhibition Model, by Agar Well
Diffusion Technique
Authors: Kumar Harish , Verma Madhu , Garg Harshit , Garg Ishu , Sharma Ishika 
Published: December 2023

Background::
Neem (Azadirachta indica) can be considered as a boon to mankind as
it possesses innumerable medicinal benefits despite being cost effective. Its use as an anti-acne
agent is widely anticipated. A topical formulation of neem leaf powder as hydrogel was prepared
recognizing the use of its phytoconstituents in many skin therapies. The primary goal of topical
formulations is to provide drug contact with the skin while reducing overall absorption.

Aim::
The aim of this study was to evaluate the anti-acne potential of Neem leaves powder hydrogel.

Method::
Neem powder was tested for its organoleptic and physical characteristics. Neem hydrogel
was prepared in a 1% w/v carbopol gel and evaluated by agar disk diffusion. A 3% w/w (F1)
and 2% w/w (F2) hydrogel prepared by adding 3g and 2g, respectively, to the prepared carbopol
gel making a volume of 100 ml, was evaluated for various parameters. A comparative evaluation
tests were conducted for F1, F2 and 1% w/v carbopol gel (blank). After the test results, F1 was
optimized for pH and viscosity by adding triethanolamine. Optimized F1 was tested against 1%
w/w salicylic acid gel, and Zitcare-S (Standard) for anti-acne activity. Agar plates were prepared
and a well was dug using a borer. The wells were filled with the F1, standard and blank, inoculated
by the Staphylococcus aureus using the spread culture technique. The plates were incubated for
24 hours at standard conditions.

Results::
F1, F2, blank and standard were tested for their viscosity, spreadability, pH and some
organoleptic parameters. The test results from F1 and F2 suggested F1 to be a more efficient
hydrogel. Standard, blank and F1 were tested using agar well diffusion technique. After the incubation
period, the plates were taken out and kept on a white sheet. Using a meter scale, the radius
of the zone of inhibition was determined. It was found that F1 gave 1.7cm, standard gave 1.3cm
and blank gave 0cm radius size zone of inhibition.

Conclusion::
Test results suggest that F1 has better spreadability and viscosity in comparison to
F2. This study concludes that F1 is a more stable and efficient formulation as a hydrogel with
efficient spreadability and optimum viscosity. F1 has better anti-bacterial activity than the standard
and has better anti-acne potential.
INTENTION TO BLOOD DONATION: AN EFFECT OF SOCIAL MEDIA
Authors: Setyawan Didik , Kristanti Monica , Sugiyarmasto Sugiyarmasto , Zailani Abdullah 
Published: December 2023

Indonesian people are still reluctant to donate blood. Lack of information and low level of awareness are the causes of this phenomena. Social media has a role in delivering comprehensive information about blood donation. This study aimed at examining the effects of social media in influencing individuals to donate blood. The quality of argumentation, interactive, and social media features can increase the positive attitude to donate blood and to establish blood donation intention. Data collection used were online questionnaire of @sahabatdonordarah Instagram followers as many as 200 respondents. The result of hypothesis testing using the AMOS Structural Equation Modeling analysis showed that the quality of argumentation and interactive social media had an effect on the positive attitude of blood donors in forming blood donation intentions, but it was not for social media features. These results indicated that the quality of the argumentation and interactive social media had a strong role in increasing the positive attitude of donating blood which could influence the intention to donate blood.
Perpanjangan dan Pembaruan Hak Atas Tanah Bagi Investor di Ibu Kota Nusantara
Authors: Cahyono Johanes 
Published: December 2023

Indonesia is a developing country that is trying to carry out national development. National development in Indonesia is philosophically based on Pancasila and the 1945 Constitution of the Republic of Indonesia, as Pancasila is the way of life of the Indonesian nation. The essence of national development is to realize national goals, one of which concerns social welfare. Social welfare is closely related to economic development. The Indonesian nation is currently making efforts to accelerate economic development towards stability and economic growth by paying attention to aspects of economics overeignty. Efforts to accelerate economic development are achieved through investment by making maximum use of fertilization and utilization of domestic investment and foreign investment. In 2022, the Government of the Republic of Indonesia promulgated Law Number 3 of 2022 concerning the National Capital which regulates there location of the National Capital, one of which is due to the economic gap between Java and outside Java and there are studie swhich show that Jakarta is no longer able to carry out its role as the capital city. The Government of the Republic of Indonesia needs investors to support facilities and infrastructure in the new National Capital. The Minister of Agrarian Affairs and Spatial Planning or the National Land Agency emphasized that it would provide convenience for land matters, spatial planning and business licensing to attract investors to invest in the National Capital City. One way to facilitate this matter is bygranting land rights in the form of building user rights for 160 (one hundred and sixty) years to investors. The convenience provided seems to only prioritize the interests of investors and if it is realized it will create legal uncertainty for investors.
Unveiling Deceptive Claims: A Cross-Sectional Observational Assessment of Dietary Supplement Advertisements from Three News Channels in Romania
Authors: Nădăşan Ingrid , Pethő Adél , Herţeliu Agnos Milian , Nădăşan Valentin 
Published: December 2023

AbstractDietary supplements can provide the necessary nutrients for groups of people who need them, but their use comes with a few risks, such as excessive or unwarranted utilization, side effects, unwanted interactions, and the promotion of unhealthy behaviors or neglecting professional health care. This cross-sectional study analyzed 49 TV advertisements on three major news channels in Romania regarding their compliance with European and national laws concerning the advertisement of dietary supplements. A list of criteria was extracted from the current laws in Romania and was used to check the video promotional materials’ compliance systematically. Despite more than half of the commercials complying with the technical criteria, it was found that a concerning amount of advertisements targeted people with various or specific pathologies, while a third of the ads included non-compliant words or representations associated with pathologies and medical professionals or institutions. As a practical implication, the study suggests a need for more consistent and closer surveillance of dietary supplement commercials broadcasted in the Romanian media.
Plant Species Important for Pollinating Insects. Case Study: Băiceni Locality (Botoşani County)
Authors: Sandu Florentina , Irimia Irina , Stratu Anișoara 
Published: December 2023

Abstract
The aim of this paper is to point out plant species that are of benefit to pollinators, from the territory of the Băiceni (Botoșani county, NE region of Romania). The plant species were analyzed on the basis of the specialized literature as follows: bioform, flowering period, flower grouping, flower color, floral resources, melliferous potential. A number of 106 plant species belonging to 31 botanical families were identified; 41.50% are woody species and 58.50% are herbaceous species. The representative botanical families are: Rosaceae (19.81%), Fabaceae (14.15%) and Asteraceae (14.15%). The majority of the species recorded in the area of study have flowers grouped in inflorescences, blooming in spring and summer and are nectar-polleniferous. The color of the flowers varies from white, yellow, yellow-green to red, blue, purple. These species are an essential resource for pollinators (mainly for the honeybee) and thus contribute to keeping the ecological equilibrium of the ecosystems in the study area and to supporting local beekeeping.
Rediscovering the Historical Gardens in the Banat County
Authors: Hegedüs Noémi Melitta , Lihăt Ildikó , Ványolos Endre , Henning Anna Imola , Szekely-Varga Zsolt , Kentelky Endre 
Published: December 2023

Abstract
The study of non-historical monument gardens aimed to inventory and assess their current state compared to the original. These gardens were researched in detail, following the steps used for historical parks and gardens. Unclassified gardens were categorized using newly established criteria based on collected information. While there’s less data about these gardens compared to historical ones, the primary goal of redevelopment is to recreate their era’s ambiance while preserving existing landscape, dendrological, and architectural values.
The Ecological Perspective in Nowadays’ Urban Landscape Planning in Transylvania
Authors: Ványolós Endre , Henning Imola Anna , Lihăt Ildikó , Szabó Beáta Csilla 
Published: December 2023

Abstract
Nowadays’ (Transylvanian) urban landscape as a complex, built and natural, social and economic environment is undergoing a sudden and accelarated transformation. Urbanization is a defining feature of current spatial/urban metamorphosis in Transylvania, too, yet the current model of urban development profoundly alters the natural environment, often reducing biodiversity and ultimately threatening human wellbeing. Present not only in academic theory, but in a broader sense in the daily public debate for the past decades, ecological perspective has become one of the leading design principles in nowadays’ professional practice and theory in urban and spatial planning, a compulsory attribute of the contemporary mindset and (urban) landscape. Proposed research on ecological perspective in current urban (landscape) planning in Transylvania, Romania is focusing specifically on the role ecological perspective can play in understanding, the applying the more general and complex phenomenon of sustainability in the planning and management of landscapes. The idea of sustainability, the ecoregional approach are not only traditional attributes of the historical landscape, but also generators in present day development of cities around Transylvania, Romania. The ecological approach can enhance finding solutions in urgent social and environmental challanges regarding efficient management of resources, sustainable urban and spatial planning.
A Mini Review on Biotechnological Potentials of Bioactive Compounds and Bioproducts Isolated from Cyanobacteria
Authors: Amran Ramzi H. , Jamal Mamdoh T. , Sayegh Fotoon , Bowrji Saba , Satheesh Sathianeson 
Published: December 2023

Abstract
Cyanobacteria are well-distributed, because of their ability to acclimate to various environments. Recently, cyanobacteria have received more research attention due to increasing pollution problems and global warming. They have many potential applications in the biotechnology sectors such as pharmaceuticals, bioplastics production, and cosmetics. Cyanobacteria produce many biologically active compounds that are utilized as anti-inflammatory, antiviral, antibacterial, and antifungal agents. The bioactive metabolites extracted from cyanobacteria include alkaloids, fatty acids, lipopeptides, and amides. In this minireview, the potential of some biotechnical applications are summarized to provide an account of the recent advancements in cyanobacteria research.
Short Overview of Oxidative Stress in Mental Disorders
Authors: Tan Julika Runlin , Puşcaş Amalia 
Published: December 2023

Abstract
This short overview explores the relationship between oxidative stress and mental disorders, focusing on the association with psychiatric pathologies such as Alzheimer’s disease, schizophrenia, autism, depression, and the impact of sleep deprivation. The mechanisms of mitochondrial disfunction and oxidative stress in these pathologies are described, including the physiological function of limited free radicals in signal transduction, gene transcription, neuronal plasticity and memory. Key free radicals, including hydroxyl and superoxide are highlighted, along with compounds generating free radicals. Moreover, the potential therapeutic implications of dietary supplements (zinc, selenium, magnesium, vitamin C, E, CoQ10) and lifestyle interventions with antioxidant properties are presented, laying the groundwork for future research in the field of mental health.
The Role of a Landscape Rehabilitation Student Project in Current Landscape Education - Healing Urbanization’s Footprint
Authors: Lihăt Ildikó , Birthler Klaus , Ványolos Endre , Henning Anna Imola , Hegedüs Noémi Melitta , Szekely-Varga Zsolt , Kentelky Endre 
Published: December 2023

Abstract
The Giurgeului Depression has been significantly impacted by human intervention, resulting in numerous scars on the landscape. A comprehensive rehabilitation plan is imperative for the Suseni quarry area to restore its natural features. This initiative, spearheaded by the local council and municipality, collaborates with the Sapientia Hungarian University of Transylvania’s Department of Horticulture and the Babeș-Bolyai University’s Faculty of Biology and Geology. They’ve launched a research scholarship program for students focused on a research and landscape rehabilitation plan tender within Suseni’s administrative region. Large scars created by human activities, adjacent to a valuable natural environment, significantly alter the natural landscape features and are detrimental to the visual and ecological relationship systems. Those need urgent rehabilitation. Student projects serves as a potential model for transforming natural landscapes affected by human actions. It aims to teach landscape design through experimental approaches, aligning with modern research-driven design methods for strategic planning. Moreover, it seeks to enhance student projects for practical implementation by local authorities, contributing positively to the area’s ecosystem and landscape. Much has already been taken from this landscape, and it is now time to give something back to the area, the local ecosystem, and the landscape.
Diptera Pests Occurring on Vegetable Crops in Poland
Authors: Szwejda Jerzy Henryk 
Published: December 2023

Abstract
In Poland, the share of Diptera in the species composition of the harmful entomofauna occurring on vegetable crops ranges from 20 to 25%. They occur on all vegetables grown in Poland (over 80 species and botanical varieties). Since the systematic registration of pests inhabiting crops in Poland in 1919, over 70 species of flies have been listed as pests of vegetable plants. Species from three families dominate in terms of population and numbers: Anthomyiidae with 12 species (Delia radicum, on early and late cultivars of cruciferous vegetables, mainly broccoli, cauliflower, white cabbage, kohlrabi, and radishes; Delia platura occurs annually on bean and cucumber; Delia antiqua on onion and garlic; and Pegomya hyoscyami on beetroot), Cecidomyiidae with 10 species (two species dominate, Contarinia nasturtii and Dasineura napi, on cruciferous vegetables), and Agromyzidae with 23 species (Liriomyza bryoniae on cucumbers, tomatoes, and peppers, and Phytomyza gymnostoma on leeks). Short-term, gradational occurrence of some dominant species was found, including Botanophila gnava (lettuce), Chamaepsila rosae (carrot, parsley), Delia platura (asparagus, bean), Delia radicum (broccoli, cauliflower, kohlrabi, radishes, white cabbage), Phytomyza gymnostoma (leek), Oscinella frit (corn), and Suillia lurida (garlic). However, they did not affect the level of plant production in the following years of cultivation. Apart from phytophagous species, taxa with a different trophic structure are common. These are copro-, necro-, sapro-, and zoophagous species. The most numerous were flies from the Drosophilidae family (Drosophila busckii, Drosophila limbata, Scaptomyza pallida, Fanniidae (Fannia canicularis, Fannia scalaris), Heleomyzidae (Tephrochlamys tarsalis), and Muscidae (Muscina levida, Muscina stabulans, Phaonia trimaculata). Natural enemies of insects play an important role in vegetable agrocenoses. Species belonging to the order of Coleoptera beetles (Carabidae and Staphylinidae), Syrphidae, Tachinidae, and Muscidae, mainly Phaonia trimaculata larvae, play the most important role in reducing the number of Diptera. In addition, the number of phytophages is limited by other organisms, e.g., Diplopoda, Nematoda, Arachnida, and pathogens of viral, bacterial, and fungal origin.