bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal Doppler sonography as a non-invasive technique for early detection of reno-vascular changes in sickle cell disease in children
Authors: Eltagui Mona Hassan , Seif Eldein Hadeel M. , Elhady Marwa Abd , El-Sayed Dalia , Momen Nouran , Selim Yasmeen M. M. , Salam Mai Mohammed Abd EL 
Published: November 2023

Abstract
Objective
Early identification of sickle renovascular changes via renal Doppler sonography among sickle cell disease patients to help in early diagnosis and interventions to prevent progression to end-stage renal disease.

Methods
Forty-five SCD children were included along with 45 healthy control children. Renal Doppler sonography (PI and RI) was performed on all subjects.
Laboratory investigations were done: Hb electrophoresis, complete blood picture with blood indices, reticulocyte count, liver enzymes (ALT and AST), HCV serology, serum ferritin, and lactate dehydrogenase (LDH). Urine analysis and albumin/creatinine ratio in urine were done for all patients as well.

Results
The study group consisted of 45 SCD patients, 27 (60%) males with a mean age of 12 years (± 3 years). By performing renal Doppler sonography, it was found that all study groups had significantly higher Doppler indices (resistivity index and pulsatility index) compared to the control group.
Results of renal Doppler sonography revealed that the main renal pulsatility index was positively correlated with the main renal resistance index (r = 0.454, p = 0.002).

Conclusion
Doppler indices (resistance index and pulsatility index) were of value to assess reno-vascular changes in SCD, Thus, renal Doppler indices could be an early technique in the assessment of sickle renovascular changes, so treatment can be started at an early stage before progressive affection of renal function.
Immunohistochemical assessment of the potential behavior of glandular odontogenic cyst and inflammatory periodontal cyst using E-cadherin and N-cadherin
Authors: Saleh Heba Ahmed , Makawi Dina M. , Rashad Asmaa Emad El-Din Mohamed 
Published: November 2023

Abstract
Background
This study is done to evaluate the immunohistochemical expression of E-cadherin and N-cadherin in glandular odontogenic cysts (GOC), inflammatory periodontal (IPDL) cysts, and dental follicles (DF), and if there is a correlation with their biological behavior GOC, IPDL cysts, and DF cases were collected and investigated by immunohistochemistry. The area percent of immunoexpressed markers was calculated by SPSS version 25.

Results
The statistical analysis revealed a clear, statistically significant difference between the studied groups regarding the area percentage of the two immune-expression markers (p value = 0.000). The highest area percentage of the mean value of E-cadherin was recorded in IPDL cysts group with the most negligible value recorded in the group of GOC. On the other hand, the highest area percentage of the mean value of N-cadherin was documented in the group of GOC with the least recorded value was noted in the group of DF.

Conclusion
We noted that the cadherin switch mechanism in the epithelial lining of odontogenic cysts is a critical step in the epithelial mesenchymal transition process which may associates with clinical behavior and may also impact the mode of treatment.
Type selection, structural calculation and construction of anchorage in Sichuan bank of Sichuan Kahalo Jinsha River Bridge
Authors: Tao Qiyu , Xu Qigang , Chen Li , Gu Rui 
Published: November 2023

AbstractSichuan kahalo Jinsha River Bridge is a suspension bridge with a main span of 1030 m, and the anchorages on both sides are gravity anchorages. In order to adapt to special terrain and geological conditions, anchorage of Sichuan bank pioneered the use of frame structure as the anchorage foundation. The soil and the frame structure jointly bear the vertical load and resist the horizontal component of the main cable to form a "frame soil" community and fully mobilize the role of the undisturbed soil. In order to ensure the integrity of the frame structure, the indirect head of the slot section adopts a rigid joint. At the same time, the distributed grouting technology is used to strengthen the soil around the frame structure, so as to further improve the safety factor.This paper introduces the topography and geology of the anchorage position, compares and selects different anchorage foundation schemes, and explains in detail the design concept, structure size and construction technology of the frame foundation.The research shows that using frame structure as anchor foundation is not only reasonable, safe, good economy, but also environmentally friendly. It has solved the difficult problem of anchorage design under poor terrain and geological conditions, and will provide a good reference for the design of mountainous suspension bridges in similar condition.
Determinants of Bone-Modifying Agent Prescribing for Metastatic Castration-Resistant Prostate Cancer in a National Health Care Delivery System
Authors: Nguyen Charles B. , Kobe Christopher , Kumbier Kyle E. , Bauman Jordan , Burns Jennifer A. , Tsao Phoebe A. , Sparks Jordan B. , Skolarus Ted A. , Caram Megan E.V. 
Published: November 2023

PURPOSE Despite guidelines recommending bone-modifying agents (BMAs) to decrease skeletal-related events (SREs) in men with metastatic castration-resistant prostate cancer (mCRPC), BMAs are underutilized. In this retrospective cohort study, we report the factors associated with BMA use in a national health care delivery system. METHODS We used the Veterans Affairs Corporate Data Warehouse to identify men with mCRPC between 2010 and 2017. BMA prescribing frequency was evaluated, and the association between patient- and disease-specific factors with BMA use was assessed using multivariable logistic regression. RESULTS Among 3,980 men identified with mCRPC (mean age 73.5 years, 29% Black), 47% received a BMA; median time to BMA from start of mCRPC treatment was 102 days. Factors associated with BMA use included previous BMA use (adjusted odds ratio [aOR], 7.81 [95% CI, 6.48 to 9.47]), diagnosis code for bone metastases (aOR, 1.26 [95% CI, 1.08 to 1.46]), and concomitant corticosteroid use (aOR, 1.53 [95% CI, 1.29 to 1.82]). Decreased BMA use was associated with advancing age (aOR, 0.85 per 10 years [95% CI, 0.78 to 0.92]), Charlson comorbidity index ≥2 (aOR, 0.76 [95% CI, 0.63 to 0.93]), Black race (aOR, 0.83 [95% CI, 0.70 to 0.98]), and decreased estimated glomerular filtration rate (eGFR; aOR, 0.19 [95% CI, 0.11 to 0.32] for eGFR 0-29 mL/minutes; aOR, 0.76 [95% CI, 0.64 to 0.91] for 30-59 mL/minutes). CONCLUSION Patients who are older, Black, or have more comorbidities are less likely to receive guideline concordant care to prevent SREs. These observations highlight the unique challenges of caring for patients with mCRPC and the need for future studies to increase BMA use in these populations.
First-Principle Investigation of La0.7Ba0.3Mn(1-x)FexO3 Structural Properties Using CASTEP
Authors: Saptari Sitti Ahmiatri , Aulia Sarah , Rizaldy Ryan , Azhar Anugrah 
Published: November 2023

<p>We conducted first-principles Density Functional Theory (DFT) calculations using the CASTEP software package to investigate the crystal structure and mechanical properties of Fe<sup>3+</sup>-doped La<sub>0.7</sub>Ba<sub>0.3</sub>MnO<sub>3</sub> material at the Mn<sup>3+</sup> site, with doping concentrations ranging up to 50%. Through geometry optimization, we simulated the X-ray diffraction (XRD) pattern. We observed that the doping of Fe did not result in a shift in the peak positions of the diffraction pattern. However, it led to an increase in intensity at the [012] peak and the splitting of peaks [104] and [110]. Regarding the mechanical properties, we examined the elastic constants and observed a reduction in the Bulk, Shear, and Young's modulus values. The Shear and Bulk modulus and Poisson's ratio indicated that La<sub>0.7</sub>Ba<sub>0.3</sub>Mn<sub>(1-x)</sub>Fe<sub>x</sub>O<sub>3</sub> becomes less ductile with increased Fe<sup>3+</sup> doping content. Furthermore, we performed calculations for the Debye temperature, which revealed a decrease in the thermal conductivity of the La<sub>0.7</sub>Ba<sub>0.3</sub>Mn<sub>(1-x)</sub>Fe<sub>x</sub>O<sub>3</sub> material.</p><p class="Abstract"> </p>
fenomen «poiètic» de María Zambrano
Authors: Enquist Källgren Karolina 
Published: November 2023

El fenomen, juntament amb la noció de forma i reducció, és un dels conceptes clau per entendre el desenvolupament crític que fa María Zambrano de la fenomenologia. Aquest article sosté que cal interpretar la noció com a resposta a diversos problemes dins de l’epistemologia. A més, l’article mostra com la noció de fenomen està lligada a la noció de la forma, i aquesta última és el producte expressiu de la primera. Es pot concebre el fenomen en l’obra de Zambrano com un fenomen poiètic.
Dynamic beam shaping for LED lighting
Authors: Presniakov Vladimir , Zohrabyan Armen , Sova Oleksandr , Bassene Seydou , Cotovanu Mihai , Bagramyan Aram , Khodadad Behzad , Killick Tom , Galstian Tigran 
Published: November 2023

We describe an electrically tunable liquid crystal microlens array with a 65 mm clear aperture that allows the dynamic symmetric broadening of white light without mechanical movements. The fundamental mechanism of broadening is demonstrated to involve a spatial twist of molecular orientation. Continuous variations of the light divergence angle are obtained in a very large dynamic range (from 8° to 50°). Particular attention is paid to maintain the desired intensity and color temperature distributions over the angle. The developed lens may be used in various broadband illumination applications based on light-emitting diode-pumped phosphor sources.
Validating the Unmind Index as a measure of mental health and wellbeing among adults in USA, Australia, and New Zealand
Authors: Travers Eoin , Loe Bao Sheng , Sun Luning , Bolton Heather 
Published: November 2023

Background
The Unmind Index is a 26-item, 7-subscale measure of mental health and wellbeing designed for use on the Unmind digital workplace mental health platform. The Unmind Index was developed and validated in the UK but is used internationally. This paper reports further psychometric validation of this measure for use in USA, Australia, and New Zealand (ANZ).

Methods
Participants in four countries completed the Unmind Index and a battery of existing measures. In Study 1 (N = 770), we validated the Unmind Index separately in USA and in ANZ. In Study 2 (N = 600), we used multiple group confirmatory factor analysis to test the measurement invariance of the Unmind Index across the UK, USA, and ANZ.

Results
Study 1 establishes the factor structure, reliability, convergent and discriminant validity, and measurement invariance by age and gender of the Unmind Index separately for USA and for ANZ. Study 2 further demonstrates measurement invariance across locations, and establishes benchmark scores by location, age, and gender.

Conclusions
We conclude that the Unmind Index is valid and reliable as a measure of mental health and wellbeing in these locations.
Impact of hospitalization on nutritional status in persons aged 65 years and over (NUTRIFRAG Study): Protocol for a prospective observational study
Authors: Carretero-Randez Cristina , Orts-Cortés María Isabel , Rodríguez-Pérez Margarita , Gonzalez-Chordá Víctor Manuel , Trescastro-López Eva María , Blanco-Blanco Joan , Martínez-Soldevila Jordi , Ruiz-Heras-Hera Aránzazu , Castellano-Santana Pedro Raúl , Marquez-Sixto Amando , Domingo-Pozo Manuela , Zomeño-Ros Antonia Inmaculada , Montero-Marco Jesica , Charlo-Bernardos Marta , Moncho Joaquín , Abad-González Ángel Luís , Castillo-García María Trinidad , Sánchez-García Ana Belén , De Pascual y Medina Ana María , Clement-Santamaría Rosa Ana , Franco-Bernal Ascensión , Camacho-Bejarano Rafaela 
Published: November 2023

Background
Malnutrition is a recurring problem that has become more relevant in recent years. The aim of this study is to assess the risk of malnutrition and nutritional status on admission and its evolution until discharge in patients aged 65 and over admitted to medical and surgical hospitalization units in hospitals of the Spanish National Health System.

Methods
Prospective observational study to be carried out in the medical-surgical hospitalization units of 9 public hospitals between 01/09/2022 and 31/12/2024. Using consecutive sampling, a total of 4077 patients will be included (453 in each hospital). Variables included are related to the care process, functionality, cognition and comorbidity, risk profile, nutritional status and dysphagia; as well as frailty, dietary quality and contextual variables. The incidence of risk of malnutrition, undernutrition and dysphagia during the care process and at discharge will be calculated. The association with risk factors will be studied with logistic regression models and multivariate Cox regression models. In addition, an analysis of participants’ satisfaction with food services will be carried out. The study was approved by the Ethics and Research Committee on 30/09/2020, approved for funding on 02/12/2021 and with registration number RBR-5jnbyhk in the Brazilian clinical trials database (ReBEC) for observational studies.

Discussion
Some studies address nutritional status or dysphagia in older people in various care settings. However, there is a lack of large sample studies including both processes of the impact of hospitalization. The results of the project will provide information on the incidence and prevalence of both pathologies in the study subjects, their associated factors and their relationship with the average length of stay, mortality and early readmission. In addition, early detection of a problem such as malnutrition related to the disease and/or dysphagia during a hospital stay will favor the action of professionals to resolve both pathologies and improve the health status of patients.
Adherence to different complementary feeding methods in the first year of life: A randomized clinical trial
Authors: Sanini Belin Christy Hannah , Nunes Leandro Meirelles , Ficagna Cátia Regina , Neves Renata Oliveira , Moreira Paula Ruffoni , Bernardi Juliana Rombaldi 
Published: November 2023

Background
Infant-guided methods, such as Baby-Led Introduction to SolidS (BLISS), encourage children to feed themselves from the same food consumed by their family since the beginning of the introduction of complementary foods, in opposition to the Parent-Led Weaning (PLW) method, which proposes foods mashed with a fork and given by parents. Adherence to child-guided methods is low due to a lack of confidence in the children’s ability to feed themselves. This study aimed to assess adherence to three methods of food introduction: PLW, BLISS, or mixed (PLW and BLISS) at seven, nine, and 12 months of age.

Methods
A randomized clinical trial was conducted with mother-infant pairs undergoing intervention at 5.5 months of age. Data were presented in absolute numbers and percentages and analyzed using the Chi-Square test.

Results
The sample was constituted of 139 mother-infant pairs: 45 (32%) used PLW, 48 (35%) used BLISS, and 46 (33%) used the mixed method. Adherence to the method at seven, nine, and 12 months of age children was 34.1% (n = 45), 28.5% (n = 37), and 34.1% (n = 46), respectively. The mixed method presented significantly higher adherence results: 69.0% (n = 29) at seven months, 55.8% (n = 24) at nine months, and 78.6% (n = 33) at 12 months (p<0.001). Among the sample that unfollowed the proposed method, those who used PLW and BLISS migrated mostly to the mixed method at 12 months, 60.0% (n = 27) and 72.9% (n = 35) of them, respectively, because of the feeding mode and 97.8% (n = 44) and 100.0% (n = 48) because of food consistency.

Conclusion
Complementary feeding in a mixed method presented higher adherence at seven, nine, and 12 months of age of children, which shows the feasibility of this approach to guide families in the introduction of complementary feeding.
Proximal determinants of suboptimal early child development during the first three years of life in socially deprived Mexican contexts
Authors: Serván-Mori Edson , Quezada-Sánchez Amado D. , Fuentes-Rivera Evelyn , Pineda-Antunez Carlos , Hernández-Chávez María del Carmen , García-Martínez Angélica , García-Feregrino Raquel , Madrigal Abby , Guerrero Bárbara , Medrano Gerónimo , Schnaas Lourdes 
Published: November 2023

Assessing the status and determinants of early child development (ECD) requires accurate and regularly updated measurements. Yet, little information has been published on the subject in low- and middle-income countries, particularly regarding the proximal determinants of childhood development in contexts of high social marginalization. This article analyzes the factors that favor or mitigate suboptimal ECD outcomes in Mexico. A cross-sectional study was conducted using recently collected data for 918 children aged 0–38 months from socially marginalized communities in 23 Mexican municipalities. The ECD outcomes of the children were estimated based on indicators of chronic undernutrition and neurodevelopment (normal, lagging and at risk of delay). The distribution of outcomes was described across the ECD proximal determinants analyzed, including the co-occurrence of chronic undernutrition and suboptimal neurodevelopment. Covariate-adjusted prevalence of the ECD outcomes and co-occurrences were calculated as post-estimations from a multiple multinomial logistic regression. The prevalence of chronic undernutrition was 23.5%; 45.9% of children were classified with neurodevelopmental lag, and 11% at risk of neurodevelopmental delay. The prevalence of stunting co-occurring with suboptimal neurodevelopment came to 15.4%. The results of the multinomial logistic regression model indicated that early gestational age, low birth weight, a low household socioeconomic level, being male and having numerous siblings were all associated with the co-occurrence of chronic undernutrition and suboptimal child neurodevelopment. This study identified important predictors of child development in the first three years of life, specifically in two of its principal indicators: nutritional and neurodevelopmental status. Most of the predictors observed can be improved by means of social programs and interventions.Trial registration:ClinicalTrials.gov ID:NCT04210362.
Perceptions of oral health promotion in primary schools among health and education officials, community leaders, policy makers, teachers, and parents in Gulu district, northern Uganda: A qualitative study
Authors: Akera Peter , Kennedy Sean E. , Schutte Aletta E. , Richmond Robyn , Hodgins Michael , Lingam Raghu 
Published: November 2023

Introduction
One in every two cases of caries in deciduous teeth occurs in low- and middle-income countries (LMICs). The aim of the World Health Organisation’s (WHO) Healthy Schools Program is to improve the oral health of children. This study explored perceptions of implementation of the Ugandan oral health schools’ program in Gulu district, northern Uganda.

Methods
Semi-structured interviews were conducted with a purposive sample of 19 participants including health and education officials, community leaders, policy makers, teachers, and parents. All interviews were transcribed verbatim and analysed thematically.

Results
Our study identified three themes: (1) components of oral health promotion, (2) implementation challenges of oral health promotion, and (3) development of an oral health policy. The components of oral health promotion in schools included engagement of health workers, the community, companies, skills-based education, and oral health services. Participants were concerned about insufficient funding, unsatisfactory skills-based education, and inadequate dental screening. Participants reported that there was an urgent need to develop oral health policy to guide implementation of the program at scale.

Conclusions
Schools provided oral health promotion that aligned with existing features of the WHO’s health-promoting school framework. Implementation of this strategy could be enhanced with increased resources, adequate oral health education, and explicit development of oral health policy.
Metastasis, characteristic, and treatment of breast cancer in young women and older women: A study from the Surveillance, Epidemiology, and End Results registration database
Authors: Gao Xiaokang , Zhang Fengxia , Zhou Qiwang , Xu Hui , Bian Jie 
Published: November 2023

Background
Younger age is an independent risk factor for breast cancer (BC) prognosis, and BC in young women is often considered more aggressive. BC patients with different age and molecular subtypes have different metastasis patterns and survival. Herein, we aim to explore the metastasis patterns, characteristics and treatment methods of young patients with BC, and to compare them with older patients.

Methods
Data of young patients (aged ≤40 years old) and older patients (aged >40 years old) with BC were extracted from the Surveillance, Epidemiology, and End Results (SEER) registration database in 2010–2019 in this retrospective cohort study. Univariate and multivariate competing risk models and proportional hazard models were used to explore the association between different metastasis patterns and treatments and BC prognoses in young and older patients. Kaplan-Meier (KM) curves were drawn to reflect the survival probability of patients with BC who have different metastasis patterns. Also, we performed subgroup analysis of different metastasis patterns to explore the association between different treatments and overall survival (OS)/cancer specific survival (CSS) in patients with BC. The evaluation index was hazard ratios (HRs) with 95% confidence intervals (CIs).

Results
Totally, 5,984 patients died, and 92.56% of them died from BC. There were respectively 1,089 young patients and 9,105 older patients, and we found some differences of characteristics and metastasis patterns between them. After adjusting for covariates, young patients who had brain metastasis and multiple sites metastasis seemed to have high risk of both lower OS and CSS. Among older patients with BC, brain metastasis, liver metastasis, and multiple sites metastasis were all positively associated with both lower OS and CSS. In young and older patients, those who not receive radiotherapy or surgery, or received non-surgery combined with radiotherapy seemed to have high risk of both lower OS and CSS. Breast-conserving surgery (BCS) and surgery combined with radiotherapy were associated with higher OS and CSS in young patients, while only older patients received surgery combined with radiotherapy had higher OS and CSS. Results of subgroup analysis indicated that for patients with different metastasis patterns, developing a personalized treatment plan is necessary.

Conclusions
Characteristics of BC between young patients and older patients were different. Clinicians should focus on different metastasis sites and choose appropriate treatments in patients with different ages, which may improve the prognoses.