bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aporte del neoconstitucionalismo a la humanización del derecho en Colombia
Authors: Romero Correa Juan Pablo 
Published: November 2023

El neoconstitucionalismo es una corriente del derecho contemporáneo que responde al novedoso interrogante de la ciencia jurídica acerca de la evolución del derecho positivo con respecto a la realización de los principios y valoresconstitucionales. La dignidad de la persona humana, en el nuevo derecho, supera el formalismo taxativo de la ley y se consagra como eje dinamizador de la fórmula del Estado Social de Derecho; en este sentido, el silencio o la ausencia de reconocimiento legal, frente a una situación conflictiva de la realidad social, no es óbice para hacer nugatorio un derecho; la dinamicidad del neoconstitucionalismo ha llevado a predicar la “omnipresencia de la Constitución” dando lugar a suscitar un “activismo judicial” como consecuencia de la indiferencia del ejecutivo y la negligencia del legislativo en atender y subvenir las necesidades más apremiantes de los asociados.
Los niños y niñas no son menores: promoción de los derechos de niños y niñas desde un enfoque social participativo proyecto de investigación proyección social, pastoral universitario y el área de humanidades
Authors: Rodríguez Páez Elsa Ruth 
Published: November 2023

La violencia que afecta y vulnera los derechos de niños y niñas es un fenómeno social evidente en la historia de la humanidad y en diversas culturas. Sus manifestaciones adquieren sentidos y significados desde las representaciones sociales y las dinámicas de poder que la legitiman. La preocupación cada vez más sentida, y fundamentada por las diversas disciplinas, acerca de la importancia de garantizar el desarrollo pleno del niño y la niña y el acceso de los mismos a los derechos que proclama la Convención Internacional de 1989, a fin de propiciar el desarrollo social y humano en todos las naciones, ha generado una nueva normatividad en el país y de igual forma ha tenido mayor injerencia en la formulación de políticas públicas con relación a la infancia y adolescencia. Sin embargo, la existencia de dicha normatividad no es garantía de un cambio en las prácticas sociales que aún en el siglo XXI no se han transformado conrelación al trato y el reconocimiento de la dignidad de la infancia y adolescencia. Por ello es fundamental que la universidad se comprometa con el proceso de transformación de las prácticas de la violencia hacía los niños yniñas, aportando desde la investigación y la proyección social para que la voz y la realidad de los niños sea escuchada y visibilizada, y para que sean los mismos niños y niñas quienes construyan y propongan nuevas formas de relacionamiento y reconocimiento de su particularidad.
El silencio cambia de color. Cátedra de estudios afrocolombianos una miradadesde los derechos humanos
Authors: Hormaza Calvache Katherin Cristina , Bolaños Jos Luis Larios , Vargas Julieth Karime García 
Published: November 2023

Esta reflexión busca resaltar la cultura afrocolombiana y refleja cuán importante es que la Constitución de 1991 promueva la diversidad étnica y cultural a través de su artículo transitorio 55 desarrollado en la ley 70 de 1993 que creó la cátedrade estudios afrocolombianos como una nueva alternativa para rescatar la identidad afrocolombiana que exceda el concepto de etnoeducación -aunque lo tiene en cuenta yapunta al respeto por los derechos humanos (educación y diversidad). El análisis antes descrito se enfoca únicamente en la ciudad de Villavicencio sobre la implementación de la cátedra en algunas instituciones de básica primaria.
Las megatendencias del siglo XXI y su incidencia en la formación del contador público
Authors: Parra González Laura Melissa , Pérez Urmendiz Jessica Lorena , Reyes Valenzuela Lina María , Roa Villasana Luis Felipe , Ruiz Osorio Ruddy Alejandra 
Published: November 2023

La evolución de las estructuras sociales, políticas, económicas y lo ambiental a nivel mundial, en gran medida han sido generadas por la globalización que a su vez ha dado origen a las "Mega tendencias del siglo XXI" como son: internacionalización de la economía, sociedades del conocimiento, paradigma científico-tecnológico (tecnologías de la información y la comunicación TIC), transformación de los estados, internacionalización de la profesión contable (armonización de normas contables NIC, NIIF) y la educación para el siglo XXI (UNESCO). Las tendencias económicas, políticas y sociales que ha traído la globalización han sido contundentes, la Contaduría Pública como profesión no puede desconocer estas transformaciones y es una responsabilidad de nuestra disciplina estar actualizada y continuar en la a construcción de su estructura teórica que posibilite la aplicación o que se materialice en el entramado empresarial.
El discurso de la calidad educativa en la actualidad de América Latina
Authors: Muñoz Cepeda Ana Camila 
Published: November 2023

La calidad en la educación es un tema de gran auge y discusión en la actualidad, particularmente en los contextos latinoamericanos. Los cambios históricos, culturales, sociales y económicos, sin lugar a duda permean en la educación y sus sistemas. Las necesidades de la población también cambian con el transcurrir del tiempo, las innovaciones y la apertura en el campo científico y tecnológico hacen que la educación se renueve y se abra al mundo. Bajo estas condiciones, la gran preocupación de los gobiernos y los estudiosos del tema ha sido cómo ofrecer una educación de calidad en los países latinoamericanos.
Las mediciones cuantificables de la calidad educativa permiten, de cierta manera, verificar la adquisición y generación de conocimiento en los estudiantes; sin embargo, más allá de los aspectos cuantitativos, es vital dar la importancia pertinente a los procesos cualitativos, que se manifiestan esencialmente en el impacto y la transformación social de los contextos en los cuales se desarrollan los estudiantes. Los sistemas educativos pueden ser de calidad, en tanto planeen sus estrategias con la participación de todos los actores involucrados en la escuela.
The Effect of Nearpod Toward Tenth-Grade Students’ Reading Skill in A Public Senior High School in North Bali, Indonesia
Authors: Wanda Dian Paramesti Fortuna Dewi  , Made Hery Santosa  , Kadek Sintya Dewi  
Published: November 2023

ABSTRACT

This research aims to find out the effect of ICT tool, Nearpod, on students' reading skill. The researcher employed a mixed-method approach by combining a post-test-only design and an interview guide. An independent-sample t-test is carried out to examine quantitative data, whereas interactive model analysis is used to analyze qualitative data. The research population including tenth-grade students at SMA Negeri 1 Banjar. 29 students from X8 class are set as experimental group and 31 students from X1 as control group. The research findings revealed that the implementation of Nearpod significantly affects students’ reading skill at SMA Negeri 1 Banjar. The result show mean score of experimental group (M=80.76) is higher compared to control group (M=70.77). The interview results revealed that Nearpod positively impacted the reading-learning process. Students can access the material anytime and from any location via Nearpod. Additionally, it improves learning effectiveness, efficiency, and interest. Further study is encouraged to investigate the effect of Nearpod on other English skills, disciplines, or levels.

Keywords: Reading Skill, Nearpod, English Language, MALL, ICT Tools in ELT
.

ABSTRAK

Penelitian ini bertujuan untuk mengetahui pengaruh perangkat TIK, Nearpod, terhadap keterampilam membaca siswa. Peneliti menggunakan pendekatan campuran dengan mengabungkan desain post-test only dan wawancara. Independent-sample t-test digunakan untuk menguji data kualitatif, sementara model analisis interaktif digunakan untuk menganalisis data kualitatif. Populasi penelitian meliputi siswa kelas 10 di SMA Negeri 1 Banjar. 29 siswa yang berasal dari kelas X8 ditetapkan sebagai kelompok eksperimen dan 31 siswa dari kelas X1 ditetapkan sebagi kelompok kontrol. Hasil penelitian mengungkapkan bahwa pengimplementasian dari aplikasi Nearpod secara signifikan telah mempengaruhi keterampilan membaca siswa di SMA Negeri 1 Banjar. Hasil menunjukan rata-rata dari grup eksperimental (M=80.76) lebih tinggi dibandingkan dengan rata-rata grup kontrol (M=70.76). Hasil interview menunjukan bahwa Nearpod secara positif telah mempengaruhi proses pembelajaran membaca suswa. Siswa dapat dengan mudah mengakses materi kapanpun dan dimanapun dengan Nearpod. Nearpod juga meningkatkan efektivitas, efesiensi, dan ketertarikan dalam belajar. Penelitian lebih lanjut dianjurkan untuk meneliti pengaruh Nearpod pada keterampilan Bahasa Inggris, disiplin ilmu, atau pada level yang berbeda.

Kata Kunci: Keterampilan Membaca, Nearpod, Bahasa Inggris, MALL, Perangkat TIK dalam Pembelajaran Bahasa Inggris
Li on a Ch Divacancy Self-Healed Graphane: A First -Principles Study
Authors: Mapasha Refilwe Edwin , Kgalema Sentserere Phodisho , Mapingire Hezekia , Igumbor Emmanuel 
Published: November 2023

The possibility of using graphane monolayer crystals as the electrode material is becoming popular. Graphane is stable at room temperature and has large surface area, but its chemical inertness hinders its direct interactions with Li ions. In this study, we performed density functional theory calculations to study the energetic stability, structural and electronic properties of Li on graphane with various CH divacancy configurations (v12, v13 and v14 ). The results show that adsorption of Li atom reduces the formation
energy of the CH divacancy configurations. The Li-v12 is most stable with the highest binding energy of 3.25 eV/Li and relaxes to in-plane with other C atoms. Altering the Li charge state to have Li−1-v12 or Li+1 -v12 affects the energetic stability and electronic characters of Li-v12 . The Li−1-v12 (Li +1-v 12 ) enhances (reduces) the binding force between Li and v 12 configuration, and furthermore it improves (deteriorates) the conductivity of the structure. Further investigation of graphane with vacancies is encouraged due to these intriguing observations, as it holds promise for potential utilization as an electrode material.
Effects of Physical Exercise and Motor Activity on Depression and Anxiety in Post‐Mastectomy Pain Syndrome
Authors: Calapai Marco , Puzzo Luisa , Bova Giuseppe , Vecchio Daniele Alfio , Blandino Rosario , Barbagallo Alessia , Ammendolia Ilaria , Cardia Luigi , Calapai Fabrizio , Currò Mariaconcetta , Ficarra Giovanni , Esposito Emanuela , Trimarchi Fabio , Di Mauro Debora , Calapai Gioacchino , Mannucci Carmen 
Published: November 2023

Background: Chronic post-surgical pain is a condition persisting at least three months after surgery. It is estimated that 25-60% of patients who underwent breast cancer removal surgery suffer from post-mastectomy pain syndrome and occurred anxiety, depression, sleep disturbance and catastrophizing. Physical activity can reduce the risk of chronic diseases and has a good impact on mood and cognitive function. Aim of this study was to evaluate the effects of physical activity on the intensity of pain, depression and anxiety in women underwent mastectomy for breast cancer removal. Methods: A prospective observational unicentric cohort study was performed. Patients were female underwent unilateral or bilateral mastectomy. Numerical Rating Scale (NRS), was used to assess pain intensity, Beck’s Depression Inventory (BDI) for depression and Generalized Anxiety Disorders-7 (GAD-7), for anxiety evaluation. Physical activity was assessed by International Physical activity questionnaire (IPAQ). Interleukin (IL)-17, IL-1β, cortisol, adrenocorticotropic hormone (ACTH) and brain-derived neurotrophic factor (BDNF) were also evaluated in the blood of patients. All the evaluation was assessed 3 and 6 months after the surgery. Results: Adequate physical activity reduced intensity of pain, depression and anxiety symptoms in women affected by post-mastectomy pain syndrome. Moreover, adequate active women, showed a reduction of biomarkers of inflammation, cortisol, ACTH and an increase of BDNF. Conclusions: Our results suggest that physical activity can improve quality of life, reducing intensity of pain, inflammatory markers and it can be useful in the reduction of associated anxiety and depression.
Tissue-resident memory T cells in Epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in Atrial Fibrillation
Authors: Longhi Paula , Vyas Vishal , Sandhar Balraj , Wood Elizabeth , Blythe Hazel , Jones Aled , Shahaj Eriomina , Fanti Silvia , Williams Jack , Metic Nasrine , Efremova Mirjana , Ng Han Leng , Feldhahn Niklas , Marelli-Berg Federica , Tinker Andrew , Finlay Malcolm 
Published: November 2023

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia and carries an increased risk of stroke and heart failure. Here, we investigate how the immune infiltrate of human epicardial adipose tissue (EAT), which directly overlies the myocardium, contributes to AF. Flow cytometry analysis revealed an enrichment of tissue-resident memory T (TRM) cells in AF patients. Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) and single-cell TCR sequencing, identified two transcriptionally distinct CD8+ TRM cells that are modulated in AF. Spatial transcriptomic analysis of EAT and atrial tissue identified the border region between the tissues to be a region of intense inflammatory and fibrotic activity, while the addition of TRM populations to atrial cardiomyocytes demonstrated their ability to differentially alter calcium flux as well as activate inflammatory and apoptotic signalling pathways. This study identified EAT as a novel reservoir of TRM cells that can directly modulate vulnerability to cardiac arrhythmia.
Genetic Insights into the 'Sandwich Fusion' Subtype of Klippel-Feil Syndrome: Novel FGFR2 Mutations Identified by 21 cases of Whole-Exome Sequencing
Authors: Hung Kan-Lin , Xu Nanfang , Gong Xiaoli , Fan Dongwei , Tian Yinglun , Yan Ming , Wei Yuan , Wang Shenglin 
Published: November 2023

Abstract
Background
Klippel-Feil syndrome (KFS) is a rare congenital disorder characterized by the fusion of two or more cervical vertebrae during early prenatal development. This fusion results from a failure of segmentation during the first trimester. Although six genes have previously been associated with KFS, they account for only a small proportion of cases. Among the distinct subtypes of KFS, "sandwich fusion" involving concurrent fusion of C0-1 and C2-3 vertebrae is particularly noteworthy due to its heightened risk for atlantoaxial dislocation. In this study, we aimed to investigate novel candidate mutations in patients with "sandwich fusion."
Methods
We collected and analyzed clinical data from 21 patients diagnosed with "sandwich fusion." Whole-exome sequencing (WES) was performed, followed by rigorous bioinformatics analyses. Our focus was on the six known KFS-related genes (GDF3, GDF6, MEOX1, PAX1, RIPPLY2, and MYO18). Suspicious mutations were subsequently validated through in vitro experiments.
Results
Our investigation revealed two novel exonic mutations in the FGFR2 gene, which had not previously been associated with KFS. Notably, the c.1750A > G variant in Exon 13 of FGFR2 was situated within the tyrosine kinase domain of the protein, in close proximity to several established post-translational modification sites. In vitro experiments demonstrated that this certain mutation significantly impacted the function of FGFR2. Furthermore, we identified four heterozygous candidate variants in two genes (PAX1 and MYO18B) in two patients, with three of these variants predicted to have potential clinical significance directly linked to KFS.
Conclusions
This study encompassed the largest cohort of patients with the unique "sandwich fusion" subtype of KFS and employed WES to explore candidate mutations associated with this condition. Our findings unveiled novel variants in PAX1, MYO18B, and FGFR2 as potential risk mutations specific to this subtype of KFS.
A Control Oriented Strategy of Disruption Prediction to Avoid the Configuration Collapse of Tokamak Reactors
Authors: Gelfusa Michela , Murari Andrea , Rossi Riccardo , Craciunescu Teddy , Vega Jesus 
Published: November 2023

Abstract
The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. Deploying new analysis methods on thousands of JET discharges, covering the isotopic compositions from hydrogen to full tritium and including the last major D-T campaign, the nature of the various forms of collapse is investigated. A new approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
Spatial-temporal variations of b-values prior to medium to large earthquakes in Taiwan and the feasibility of real-time precursor monitoring
Authors: Chan Chung-Han , Kao Jo-Chen , Chen Da-Yi 
Published: November 2023

Abstract

This study investigates the temporal and spatial variations of the b-values before earthquakes greater than magnitude 6.0 in the Taiwan region and assesses the feasibility of monitoring earthquake precursors through b-values. Using the 2018 Hualien earthquake as an example, the b-value in the vicinity of the region one year before the earthquake was in the 12th percentile of all Taiwan, indicating a relatively low spatial value. Moreover, the b-value near the epicenter noticeably decreased within a year before the earthquake, showing a temporally relative low value. Based on this experience, we examine the temporal and spatial variations of b-values before earthquakes greater than magnitude 6.0 in Taiwan from 1999 to 2021. It was found that the epicenters of many large earthquakes were in regions with relatively low b-values across Taiwan a year prior. However, the b-values around various epicenters did not show significant changes at different times before the earthquakes. To further evaluate the feasibility of real-time monitoring of earthquake precursors using b-values, we analyzed the 2022 Yuli earthquake and the Chihshang earthquake sequence as case studies. Immediate post-event analysis using the rapid earthquake report catalog showed significant anomalies in both time and space for b-values, even though the real-time catalog obtains a larger magnitude of completeness. Specifically, the b-value in the vicinity of the region one year before the earthquake was in the 3rd percentile for the entire Taiwan region; furthermore, the b-value consistently decreased within the four years preceding the earthquake. These results validate the feasibility of evaluating earthquake precursors by analyzing real-time earthquake data. To more precisely predict future earthquake activity characteristics, it is suggested to incorporate other reference factors for a comprehensive evaluation, aiming to reduce cognitive uncertainty.
Multiomics-based causal inference identifies novel therapeutic targets for inflammatory bowel disease in East Asians
Authors: Kim Jung Oh , Lee Sun Yeop , Kim Eun Gyo , Lee Eunbyeol , Lee Jihye , Shim Yu Jeong 
Published: November 2023

Abstract

Multiomics-based efforts to identify therapeutic targets for IBD have been limited to European populations. Prior reports on heterogeneity between East Asians and Europeans in clinical manifestations of IBD and genetic architectures of IBD-related variants warrant a separate investigation in East Asians. Using the East Asian genome and proteome data, we applied two multiomics-based causal inference methods, proteome-wide Mendelian randomization and causal proteome-wide association study. For IBD, Crohn’s disease (CD), and ulcerative colitis (UC), we found 30 potential drug targets with proteomic evidence. IL18R1, IL1RL1, KIR3DL1, and MEP1B had consistent associations with across IBD, CD, and UC. Fifteen targets were CD-specific, while eight were UC-specific. Among the candidate targets, thirteen and eight had supportive MR evidence in the plasma transcriptome data and the multi-tissue transcriptome data of European ancestry, respectively. IL18R1, IL6R, IL16, TNFRSF14 or their direct interactors were currently targeted by drugs being developed to treat IBD. IL1RL1 and PDGFRB had existing drugs that may be repurposed for IBD. Crucially, we identified six previously unreported target genes, opening new avenues for therapeutic interventions in IBD that warrant immediate validation in upcoming experiments and clinical trials.
The 30 Years Of Shifting In Indonesian Cardiovascular Burden -Analysis Of Global Burden Of Disease Study
Authors: Muharram Farizal Rizky , Multazam Chaq El Chaq Zamzam , Mustofa Ali , Harmadha Wigaviola Socha ,   Andrianto3 Andrianto3, Martini Santi , Aminde Leopold , Yi-Li Chung 
Published: November 2023

Abstract

Importance: Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity. Compared with disease burden rates in 1990, significant reductions in Disability-Adjusted Life Years (DALYs) burden rates for CVD have been recorded. However, general DALYs rates have not changed in Indonesia in the past 30 years. Thus, assessing Indonesian CVD burdens will be an essential first step in determining primary disease interventions.
Objective: To determine the national and province-level burden of CVD from 1990 to 2016 in China.
Design, Setting, and Participants: This research used Global Burden Disease (GBD) 2019 Institute of Health Metrics (IHME) data to analyze CVD burden trends, including mortality, morbidity, and prevalence characteristics of 12 underlying CVDs.
Exposures: Residence in Indonesia
Main Outcomes and Measures: Mortality, Incidence, prevalence, death, and DALYs of CVD.
Results: CVD Deaths have doubled from 278 million in 1990 to 651 million in 2019. ALL CVDs recorded increased death rates, except for rheumatic heart disease (RHD) (-69%) and congenital heart disease (CHD) (-37%). Based on underlying diseases, stroke and ischemic heart disease (IHD) are still the leading causes of mortality and morbidity in Indonesia, whereas stroke and peripheral artery disease (PAD) are the most prevalent CVDs. Indonesia has the second worst CVD DALYs rates compared to ASEAN countries after Laos. At provincial levels, the highest CVD DALY rates were recorded in Bangka-Belitung, South Kalimantan, and Yogyakarta. In terms of DALYs rate changes, they were recorded in West Nusa Tenggara (24%), South Kalimantan (18%), and Central Java (11%). Regarding sex, only RHD and PAD burdens were dominated by females.
Conclusions: CVD mortality, morbidity, and prevalence rates increased in Indonesia from 1990-2019. Importantly, these data could provide reference points for policymakers, such as improving risk factor prevention and health care optimization.