bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online counterfeit purchase behaviour: moderating effect of perceived anonymity and moral disengagement
Authors: Samaddar Kaushik , Mondal Sanjana , Gandhi Aradhana 
Published: October 2023

Purpose
The continuous evolution of e-commerce with young consumers’ growing interest in online shopping has transformed the retail landscape across the world. With the surge in online sales, counterfeits of luxury goods have also found themselves from brick-and-mortar shelves to online e-commerce sites. Against this backdrop, this study aims to understand and analyse young consumers’ online counterfeit purchase behaviour (OCPB). Additionally, it also aims at identifying the determinants that influence their purchase decisions.

Design/methodology/approach
Following an extensive review of the literature, the present study pursued a quantitative approach in exploring critical demographic, psychographic, behavioural and situational factors influencing OCPB. The study was conducted in India through an online survey using a structured questionnaire.

Findings
The findings indicate that young consumers’ OCPB is significantly related to influencing factors like brand consciousness, fashion involvement, face consciousness, impulsive buying tendency, acquisition centrality and utilitarian shopping values. Furthermore, moderating effects of perceived anonymity (PA) and moral disengagement (MD) on OCPB were also observed and validated.

Research limitations/implications
The study examined the critical factors and their linkages while building upon a structural framework on OCPB, keeping India as a representative sample. The proposed framework will bring more clarity and further insights that will help scholars expand the research domain with more cross-cultural studies and aid brand e-marketers to strategize their action towards developing strong brand aesthetic values.

Originality/value
The study contributes towards the literature by introducing PA and MD vis-à-vis building a framework for studying young consumers’ OCPB.
Capturing children's play behaviours in outdoor environments: A comparative analysis of play in early adolescence at primary school versus high school
Authors: Kennedy‐Behr Ann , Webb‐Williams Jane L. 
Published: October 2023

AbstractIntroductionTransition from primary school to high school can be a time of significant stress for young people. Social connection may mitigate the stress experienced by young people, yet their play activities, which are a key source of connection and friendship, have not been examined. The aim of the study was to capture the play behaviours of children in outdoor school environments.MethodsChildren's play behaviours in their final year of primary school and those in their first year of high school were captured using a standardised tool (Tool for Observing Play Outdoors). Observations occurred in school outdoor environments during break times in the South Australian autumn of 2021. Frequencies and types of play were compared between year levels using descriptive statistics and contingency tables. Data were collected from four schools (two metropolitan and two regional), which were all from a similar level on the Index of Educational Disadvantage. Four observation sessions were held at each school.ResultsParents of 42 (16 girls) primary school students and 85 (33 girls) high school students gave permission for their children to participate. Physical play was the most frequent activity observed in both primary school and high school followed by expressive play. Year level was significantly associated with the type of play engaged in.ConclusionFindings demonstrate children in the first year of high school continue to engage in physical and social play albeit less than those in the final year of primary school. Further research is needed to determine whether the physical and social environment or onset of puberty is more influential on changes in children's play.
Increased cyanophage infection at the bottom of the euphotic zone, especially in the fall
Authors: Fuchsman Clara A. , Hays Matthew D. 
Published: October 2023

AbstractPicocyanobacteria contribute greatly to offshore primary production with cells extending through the deep euphotic zone. Literature indicates high viral infection of cyanobacteria in ocean transition zones. We postulate that the bottom of the euphotic zone is a transition zone, where communities transition from phototrophic to aphotic processes. We use single‐copy core genes to examine cyanophage to cyanobacteria ratios in cellular metagenomes in the subtropical North Atlantic and Pacific. Cyanophage to cyanobacteria terL/rpoB ratios generally increase to >10 in the deep euphotic zone. As light levels decrease in the fall, Prochlorococcus in the deep euphotic zone experience reduced light levels. We find clear differences between spring (Geotraces GA02) and fall (GA03) in the North Atlantic, with terL/rpoB ratios increasing to >40 in the fall. When examining 23 months of the North Pacific Hawaii Ocean Timeseries, the depth of elevated cyanophage to cyanobacteria ratios in cellular metagenomes negatively correlated with surface photosynthetic radiation (PAR), particularly with the change in PAR, which reflected the season. In fall, all picocyanobacteria ecotypes were found at depths enriched with viruses, while in summer, only low light ecotypes were affected. Thus, we find high cyanophage infection both in the deep euphotic zone and during seasonal transitions.
Perinatal mental health screening for women of refugee background: Addressing a major gap in pregnancy care
Authors: Willey Suzanne M. , Gibson Melanie E. , Blackmore Rebecca , Goonetilleke Liyasha , McBride Jacqueline , Highet Nicole , Ball Natahl , Gray Kylie M. , Melvin Glenn , Boyd Leanne M. , East Christine E. , Boyle Jacqueline A. 
Published: October 2023

AbstractBackgroundPerinatal mental health disorders affect up to 20% of all women. Women of refugee background are likely to be at increased risk, yet little research has explored this. This study aimed to assess if women of refugee background are more likely to screen risk positive for depression and anxiety than non‐refugee women, using the Edinburgh Postnatal Depression Scale (EPDS); and if screening in pregnancy using the EPDS enables better detection of depression and anxiety symptoms in women of refugee background than routine care.MethodsThis implementation study was conducted at an antenatal clinic in Melbourne, Australia. Women of refugee and non‐refugee backgrounds were screened for depression using English or translated versions of the EPDS and a psychosocial assessment on a digital platform. The psychosocial assessment records of 34 women of refugee background receiving routine care (no screening) were audited.ResultsOverall, 274 women completed the EPDS; 43% of refugee background. A similar proportion of women of refugee and non‐refugee backgrounds had EPDS scores of ≥9 (39% vs. 40% p = 0.93). Women receiving the combined EPDS and psychosocial screening were more likely to receive a referral for further support than women receiving routine care (41% vs. 18%, p = 0.012).ConclusionSimilarly, high proportions of women of refugee and non‐refugee backgrounds were at increased risk of experiencing a current depressive disorder in early pregnancy, suggesting pregnancy care systems should acknowledge and respond to the mental health needs of these women. Screening appeared to facilitate the identification and referral of women compared to routine care.
Quantitative interpretation of bone marrow biopsies in MPN—What's the point in a molecular age?
Authors: Ryou Hosuk , Lomas Oliver , Theissen Helen , Thomas Emily , Rittscher Jens , Royston Daniel 
Published: October 2023

SummaryThe diagnosis of myeloproliferative neoplasms (MPN) requires the integration of clinical, morphological, genetic and immunophenotypic findings. Recently, there has been a transformation in our understanding of the cellular and molecular mechanisms underlying disease initiation and progression in MPN. This has been accompanied by the widespread application of high‐resolution quantitative molecular techniques. By contrast, microscopic interpretation of bone marrow biopsies by haematologists/haematopathologists remains subjective and qualitative. However, advances in tissue image analysis and artificial intelligence (AI) promise to transform haematopathology. Pioneering studies in bone marrow image analysis offer to refine our understanding of the boundaries between reactive samples and MPN subtypes and better capture the morphological correlates of high‐risk disease. They also demonstrate potential to improve the evaluation of current and novel therapeutics for MPN and other blood cancers. With increased therapeutic targeting of diverse molecular, cellular and extra‐cellular components of the marrow, these approaches can address the unmet need for improved objective and quantitative measures of disease modification in the context of clinical trials. This review focuses on the state‐of‐the‐art in image analysis/AI of bone marrow tissue, with an emphasis on its potential to complement and inform future clinical studies and research in MPN.
EpCAM and APN expression in combination with γ‐H2AX as biomarkers for detecting hepatocarcinogens in rats
Authors: Akagi Jun‐ichi , Cho Young‐Man , Toyoda Takeshi , Mizuta Yasuko , Ogawa Kumiko 
Published: October 2023

AbstractThe phosphorylated form of histone H2AX (γ‐H2AX) serves as a commonly utilized biomarker for DNA damage. Based on our previous findings, which demonstrated the formation of γ‐H2AX foci as a reliable biomarker for detecting bladder carcinogens in repeated dose 28‐day study in rats, we hypothesized that γ‐H2AX could also function as a biomarker for detecting hepatocarcinogens. However, we found that γ‐H2AX foci formation was not effectively induced by hepatocarcinogens that did not stimulate hepatocyte proliferation. Therefore, we explored alternative biomarkers to detect chemical hepatocarcinogenicity and discovered increased expressions of epithelial cell adhesion molecule (EpCAM/CD326)‐ and aminopeptidase N (APN/CD13) in the hepatocytes of rats administered various hepatocarcinogens. Significant increases in EpCAM‐ and APN‐positive hepatocytes were observed for eight and five of the 10 hepatocarcinogens, respectively. Notably, five and two of them, respectively, were negative for γ‐H2AX foci. These results highlight the potential of EpCAM and APN as useful biomarkers in combination with γ‐H2AX for the detection of chemical hepatocarcinogenicity.
Effect of delay in treatment intensification in people with type 2 diabetes and suboptimal glycaemia after basal insulin initiation: A real‐world observational study
Authors: Shabnam Sharmin , Abner Sophia , Gillies Clare L. , Davies Melanie J. , Dex Terry , Khunti Kamlesh , Webb David R. , Zaccardi Francesco , Seidu Samuel 
Published: October 2023

AbstractAimDespite global recommendations for type 2 diabetes mellitus treatment to maintain optimal glycaemic targets, a significant proportion of people remain in suboptimal glycaemic control. Our objective was to investigate the impact of intensification delay after basal insulin (BI) initiation on long‐term complications in people with suboptimal glycaemia.Materials and MethodsWe conducted a retrospective cohort study in individuals with type 2 diabetes mellitus initiated on BI. Those with suboptimal glycaemia (glycated haemoglobin ≥7% or ≥53 mmol/mol) within 12 months of BI initiation were divided into early (treatment intensified within 5 years), or late (≥5 years) intensification groups. We estimated the age‐stratified risks of micro‐ and macrovascular complications among these groups compared with those with optimal glycaemia (glycated haemoglobin <7%).ResultsOf the 13 916 people with suboptimal glycaemia, 52.5% (n = 7304) did not receive any treatment intensification. In those aged <65 years, compared with the optimal glycaemia group late intensification was associated with a 56% higher risk of macrovascular complications (adjusted hazard ratio 1.56; 95% confidence intervals 1.08, 2.26). In elderly people (≥65 years), late intensification was associated with a higher risk of cardiovascular‐related death (1.62; 1.03, 2.54) and a lower risk of microvascular complications (0.26; 0.08, 0.83).ConclusionsThose who had late intensification were at an increased risk of cardiovascular death if they were ≥65 years and an increased risk of macrovascular complications if they were <65 years. These findings highlight the critical need for earlier intensification of treatment and adopting personalized treatment strategies to improve patient outcomes.
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea
Authors: Zeicu Claudia , Legouhy Antoine , Scott Catherine A. , Oliveira Joana F. A. , Winston Gavin P. , Duncan John S. , Vos Sjoerd B. , Thom Maria , Lhatoo Samden , Zhang Hui , Harper Ronald M. , Diehl Beate 
Published: October 2023

AbstractObjectivesSudden unexpected death in epilepsy (SUDEP) is a leading cause of death for patients with epilepsy; however, the pathophysiology remains unclear. Focal‐to‐bilateral tonic–clonic seizures (FBTCS) are a major risk factor, and centrally‐mediated respiratory depression may increase the risk further. Here, we determined the volume and microstructure of the amygdala, a key structure that can trigger apnea in people with focal epilepsy, stratified by the presence or absence of FBTCS, ictal central apnea (ICA), and post‐convulsive central apnea (PCCA).MethodsSeventy‐three patients with focal impaired awareness seizures without FBTC seizures (FBTCneg group) and 30 with FBTCS (FBTCpos group) recorded during video electroencephalography (VEEG) with respiratory monitoring were recruited prospectively during presurgical investigations. We acquired high‐resolution T1‐weighted anatomic and multi‐shell diffusion images, and computed neurite orientation dispersion and density imaging (NODDI) metrics in all patients with epilepsy and 69 healthy controls. Amygdala volumetric and microstructure alterations were compared between three groups: healthy subjects, FBTCneg and FBTCpos groups. The FBTCpos group was further subdivided by the presence of ICA and PCCA, verified by VEEG.ResultsBilateral amygdala volumes were significantly increased in the FBTCpos cohort compared to healthy controls and the FBTCneg group. Patients with recorded PCCA had the highest increase in bilateral amygdala volume of the FBTCpos cohort.Amygdala neurite density index (NDI) values were decreased significantly in both the FBTCneg and FBTCpos groups relative to healthy controls, with values in the FBTCpos group being the lowest of the two. The presence of PCCA was associated with significantly lower NDI values vs the non‐apnea FBTCpos group (p = 0.004).SignificanceIndividuals with FBTCpos and PCCA show significantly increased amygdala volumes and disrupted architecture bilaterally, with greater changes on the left side. The structural alterations reflected by NODDI and volume differences may be associated with inappropriate cardiorespiratory patterns mediated by the amygdala, particularly after FBTCS. Determination of amygdala volumetric and architectural changes may assist identification of individuals at risk.
Joint status, pain and quality of life in elderly people with haemophilia: A case‐control study
Authors: Chantrain Valérie‐Anne , Foubert Anthe , Meeus Mira , Lambert Catherine , Lobet Sébastien , Maes Philip , Fransen Erik , Durnez Lies , Hermans Cedric , Roussel Nathalie Anne 
Published: October 2023

AbstractIntroductionElderly people with haemophilia (PwH) develop haemophilic arthropathy, pain, and reduced health‐related quality of life (HR‐QoL). The condition of elderly mild haemophilia patients have rarely been evaluated. This study aimed to compare joint status, pain, and HR‐QoL between elderly with mild, moderate/severe haemophilia and healthy elderlies.MethodsKnee/ankle abnormalities were assessed by ultrasound (HEAD‐US) and physical examination (HJHS 2.1). Pain severity and pain interference were investigated using the Brief Pain Inventory. Pressure pain thresholds (PPTs) were obtained at knees/ankles and forehead. Functional limitations were evaluated using the 2‐Minute‐Walking‐Test, Timed‐Up‐and‐Go and HAL. The EQ‐5D‐5L questionnaire evaluated HR‐QoL. Healthy controls (HCs) and elderly individuals with moderate/severe and mild haemophilia were compared using Kruskal–Wallis and Mann–Whitney U tests.ResultsFrom the 46 elderly PwH approached, 40 individuals (≥60 years) with haemophilia A/B (17 moderate/severe; 23 mild) and 20 age‐matched HCs were recruited. Moderate/severe PwH displayed worse joint status, lower PPTs, and poorer HR‐QoL than mild PwH and HCs (p‐value = .010–<.001). HEAD‐US abnormalities were observed in 100% of knees and 94% of ankles in moderate/severe PwH, versus 50% of knees and 61% of ankles in mild PwH. Pain was reported by 80% and 57% of moderate/severe and mild PwH, respectively. Low PPTs, functional limitations, and poor HR‐QoL scores were likewise observed in some mild PwH, yet without significantly differing from HCs.ConclusionThis study highlights poor joint/functional status, pain, and HR‐QoL outcomes in elderly with moderate/severe haemophilia. A few mild haemophilia subjects presented joint abnormalities, pain, functional limitations, and poor HR‐QoL, without significantly differing from HCs.Highlights
Elderly individuals with mild haemophilia have not yet been extensively studied, whereas moderate/severe haemophilia individuals have proven to suffer from haemophilic arthropathy, pain, and poor health‐related quality of life (HR‐QoL).
Using a case‐control design, joint status, pain, and HR‐QoL outcomes were examined in elderly haemophilia individuals and compared with those of healthy controls (HCs).
Elderly moderate/severe haemophilia individuals exhibited worse joint status, increased joint pain sensitivity, and reduced HR‐QoL compared with both mild haemophilia subjects and HCs. A subset of mild haemophilia subjects exhibited poor joint status, pain, and HR‐QoL outcomes, without any differences noted when compared with HCs.
Boethius's Definition of the Person in Context: Chalcedon, Tradition, and Consolation
Authors: Spun Brandon 
Published: October 2023

AbstractAbstract: While Boethius's definition of the person, ‘an individual substance of a rational nature’, plays a significant role in Christian theology and anthropology, its reception is by no means uncritical. In the last hundred years, virtually every element in it has been critiqued by theologians and secular scholars. Nevertheless, its context suggests that his understanding of the person is potentially far richer than supposed. This paper places Boethius's definition of the person in its historical framework and in the context of his own thought, especially Contra Eutyches and Consolation of Philosophy, in order to demonstrate that despite shortcomings, it represents a dynamic and holistic characterisation of the person.
Durability of the improvement of collagen I and collagen III with the use of oral isotretinoin in the treatment of photoaging
Authors: Azulay David R. , Bravo Bruna S. F. , Azulay Vitoria , Martins Fabiane F. , Luiz Ronir R. , Cuzzi Tullia , Mandarim Carlos A. , Manela‐Azulay Mônica 
Published: October 2023

AbstractBackgroundOral isotretinoin (ISO) is the drug of choice for the treatment of severe acne. For photoaging treatment, ISO has been proved to be effective in some controlled and noncontrolled trials and is an alternative to topical retinoic acid (RA) therapy, which causes an expected skin irritation.ObjectiveTo evaluate and compare the skin remodeling in patients taking ISO 20 mg 3 times a week for 12 weeks and 12 weeks after the end of the treatment to quantify collagen I and collagen III augmentation.Material and methodsImmunohistochemical studies were performed to evaluate the expression of collagen I and collagen III, metalloproteinases (MMPs) ‐1, ‐3, ‐7, ‐9, ‐12, and the tissue inhibitor of MMP type‐1 (TIMP‐1) of the skin of 20 45 to 50‐year‐old women through morphometry in a semiquantitative method. The inclusion criteria were facial aging 2 and 3 of Glogau's classification, with phototypes between II and V who had not entered menopause. Biopsies of the skin of the left preauricular region were performed at three different times: pre‐treatment (T0), end of 12‐week treatment (T1), and 12 weeks posttreatment (T2).ResultsCollagen fibers I and III increased with statistical significance in T1 (50.7%; P = 0.012) but not in T2 (49.7%), which in turn was higher than in T0 (47.2%) for collagen I and T1 (33.3%; P = 0.002) but not in T2 (32.7%), and also was higher than T0 (32.0%) for collagen III. MMP‐9 presented a decreased activity with statistical significance in T1 (P = 0.047) and T2 (P = 0.058). MMP‐1 showed a reduction in T2 only (P = 0.015). MMPs ‐3, ‐7, ‐12, and TIMP‐1 did not present significant modification in their expressions during or after the treatment.ConclusionsLow‐dose ISO is effective in remodeling the extracellular matrix (ECM). This study found that the increase of collagen occurs through the augmentation of both collagen I and collagen III fibers. With originality, it was possible to verify the durability of these fibers for at least 12 weeks. This may be related to the decrease in MMP‐9 expression verified at the end of the treatment and 12 weeks posttreatment.
Safety and quality attributes of fresh sardines (Sardina pilchardus) in storage scenarios imitating harvest‐to‐refrigerator conditions
Authors: Chatzikyriakidou Kyriaki , Dimakopoulou‐Papazoglou Dafni , Katsanidis Eugenios 
Published: October 2023

SummaryThe effect of initial storage temperature on the quality and safety characteristics of sardines was investigated. Initially, fresh sardines were stored in aerobic conditions at 0 °C, 5 °C or 10 °C for 24 h and subsequently, they were vacuum packed and stored at two distinct temperatures, namely 4 °C and 8 °C. Microbial growth, lipid oxidation (TBA values), pH, total volatile basic nitrogen (TVB‐N) and biogenic amines concentrations were monitored throughout storage. There were no notable differences in the pH levels of the different treatments, whereas higher TBA and TVBN values were observed for the sardines initially stored at higher temperatures. Significant differences (P < 0.05) in biogenic amine concentrations were observed throughout storage time. Samples exposed to lower initial temperatures exhibited longer lag times and lower production rates of biogenic amines. There were no statistically significant differences observed in microbial populations, although the sardine samples stored at 10 °C initially had the highest microbial populations. These results support the conclusion that initial handling conditions are important for the shelf‐life of fresh sardines and can drastically affect their overall quality and safety.