bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slit‐flow ektacytometry: Laser diffraction in a slit rheometer
Authors: Shin Sehyun , Ku Yunhee , Park Myung‐Su , Suh Jang‐Soo 
Published: March 2005

AbstractBackgroundDeformability of red blood cells (RBCs) is a determinant of blood flow resistance as RBCs pass through small capillaries of the microcirculation. Available techniques for measuring RBC deformability often require a washing process after each measurement, which is not optimal for day‐to‐day clinical use.MethodsA laser diffraction technique has been combined with slit‐flow rheometry, which shows significant advances in ektacytometric design, operation, and data analysis. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element that is in contact with the blood sample.ResultsWith slit ektacytometry, the deformation of RBCs subjected to continuously decreasing shear stress in a slit flow can be quickly measured with extremely small quantities of blood. The measurements with the slit ektacytometer were compared with those of LORCA and a strong correlation was apparent. The deformability of the hardened RBCs was markedly lower than that of the normal RBCs. In addition, the young cells showed higher values of the elongation index than did the old cells.ConclusionsThe newly developed slit ektacytometer can measure RBC deformability with ease and accuracy. In addition, the slit ektacytometer can be easily used in a clinical setting owing to the incorporation of a disposable element that holds the blood sample. © 2005 Wiley‐Liss, Inc.
Synthesis and Characterisation of New Iridium Complexes with the (4S)‐2‐[2‐(Diphenylphosphanyl)phenyl]‐4‐isopropyl‐1,3‐oxazoline Ligand That Catalyse Asymmetric Michael Reactions
Authors: Carmona Daniel , Ferrer Joaquina , Lorenzo Mónica , Lahoz Fernando J. , Dobrinovitch Isabel T. , Oro Luis A. 
Published: March 2005

AbstractThe chiral iridium compounds [IrCl(COE){(S)‐PN}] {COE = cyclooctene, PN = (4S)‐2‐[2‐(diphenylphosphanyl)phenyl]‐4‐isopropyl‐1,3‐oxazoline, (1)}, [Ir(acac)ClH{(S)‐PN}] {Hacac = acetylacetone, (2)} and [Ir{(S)‐PN}2]A {A = Cl (3a,b); BF4 (4a,b); PF6 (5a,b)} have been prepared, characterised and employed as catalysts for the asymmetric Michael addition of keto or cyano esters to α,β‐unsaturated carbonyl compounds. The X‐ray molecular structures of compounds 2 and 5b are reported. The model catalytic intermediates [IrH(NCCHCO2R){(S)‐PN}2]Cl {R = Me (12), Et (13)} have also been isolated and characterised. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Kinetics and Mechanism of the Demetallation of Macrocyclic Nickel(II) Complexes by Cyanide
Authors: Siegfried Liselotte , Kaden Thomas A. 
Published: March 2005

AbstractThe kinetics and the mechanism of the cyanide‐induced demetallation of a series of Ni2+ complexes with macrocyclic ligands of different ring size (12‐ to 14‐membered; see 1–4) and steric constraints was studied. Although the rates differ by almost five orders of magnitude when compared to each other under fixed experimental conditions (pH 10.5, [CN−]=10−2 M), all reactions proceed through the relatively rapid formation of cyano adducts [Ni(CN)nL] (n=1, 2), which then react with additional CN− or HCN to give the final products. Of paramount importance for the reaction rate is the geometry and configuration of the cyano adducts [Ni(CN)nL] (n=1,2). cis‐Dicyano derivatives with a folded macrocycle react faster than trans‐compounds. In the case of (1,4,8,11‐tetraazacyclotetradecane)nickel(2+) ([Ni (4)]2+), which gives a trans‐ dicyano adduct, the base‐catalyzed N‐inversion necessary to obtain the cis‐dicyano derivative becomes rate determining at high CN− concentrations.
S‐Functionalized Cysteine: Powerful Ligands for the Labelling of Bioactive Molecules with Triaquatricarbonyltechnetium‐99m(1+) ([99mTc(OH2)3(CO)3]+)
Authors: van Staveren Dave R. , Benny Paul D. , Waibel Robert , Kurz Philipp , Pak Jae‐Kyoung , Alberto Roger 
Published: March 2005

AbstractS‐Alkylated cysteines are used as efficient tridentate N,O,S‐donor‐atom ligands for the fac‐[M(CO)3]+ moiety (M=99mTc or Re). Reaction of (Et4N)2[ReBr3(CO)3] (3) with the model S‐benzyl‐L‐cysteine (2) leads to the formation of [Re(2′)(CO)3] (4) as the exclusive product (2′=C‐terminal anion of 2). The tridentate nature of the alkylated cysteine in 4 was established by X‐ray crystallography. Compound 2 reacts with [99mTc(OH2)3(CO)3]+ under mild conditions (10−4 M, 50°, 30 min) to afford [99mTc(2′)(CO)3] (5) and represents, therefore, an efficient chelator for the labelling of biomolecules. L‐Cysteine, S‐alkylated with a 3‐aminopropyl group (→7), was conjugated via a peptide coupling sequence with Coα‐[α‐(5,6‐dimethyl‐1H‐benzimidazolyl)]‐Coβ‐cyanocobamic b‐acid (6), the b‐acid of cyanocob(III)alamin (vitamin B12) (Scheme 3). More convenient was a one‐pot procedure with a derivative of vitamin B12 comprising a free amine group at the b‐position. This amine 15 was treated with NHS (N‐hydroxysuccinimide)‐activated 1‐iodoacetic acid 14 to introduce an I‐substituent in vitamin B12. Subsequent addition of unprotected L‐cysteine resulted in nucleophilic displacement of the I‐atom by the S‐substituent, affording the vitamin B12 alkylated cysteine fragment 17 (Scheme 4). The procedure was quantitative and did not require purification of intermediates. Both cobalamin–cysteine conjugates could be efficiently labelled with [99mTc(OH2)3(CO)3]+ (1) under conditions identical to those of the model complex 5. Biodistribution studies of the cobalamin conjugates in mice bearing B10‐F16 melanoma tumors showed a tumor uptake of 8.1±0.6% and 4.4±0.5% injected dose per gram of tumor tissue after 4 h and 24 h, respectively (Table 1).
Water‐Exchange Mechanism for Zinc(II), Cadmium(II), and Mercury(II) Ions in Water as Studied by Umbrella‐Sampling Molecular‐Dynamics Simulations
Authors: Inada Yasuhiro , Mohammed Ahmed M. , Loeffler Hannes H. , Funahashi Shigenobu 
Published: March 2005

AbstractUmbrella‐sampling molecular‐dynamics simulations were performed to investigate the water‐exchange reactions of zinc(II), cadmium(II), and mercury(II) ions in aqueous solution. The dissociation of a coordinating water molecule to the MO distance at 3.34, 3.16, and 3.26 Å for ZnII, CdII, and HgII, respectively, leads the system to a transition state. For ZnII, the first hydration shell is occupied by five spectator water molecules in the transition state, indicating that the water‐exchange reaction proceeds via a dissociative mode of activation. In contrast, the number of spectator water molecules of 5.85 and 5.95 for CdII and HgII, respectively, suggests an associative exchange for these larger metal ions. The average MO distance of the spectator molecules is shortened by 0.06 Å for the dissociative exchange of ZnII, while it is elongated by 0.04 and 0.03 Å for CdII and HgII, respectively. The water‐exchange rate constants of 4.1×108, 6.8×108, and 1.8×109 s−1 are estimated for ZnII, CdII, and HgII, respectively, at 298 K in terms of the transition‐state theory based on the assumption of a transmission coefficient of unity.
On the Adsorption, by Activated Carbons, of Some Sparingly Soluble Organics from Aqueous Solutions
Authors: Hugi‐Cleary Deirdre , Slasli Abdou , Stoeckli Fritz 
Published: March 2005

AbstractActivated carbons play an important role in the purification of air and of water. Whereas vapors are adsorbed by a micropore filling process, the removal of sparingly soluble species such as phenol and its derivatives is limited to the coating of the effective surface of the material. This reduces considerably the sorptive capacity of a given carbon, and a suitable description is needed to predict the corresponding equilibrium. It is shown that, in the case of phenol, its derivatives, and a few typical pollutants, the latter process can be described by an extension of the Dubinin–Radushkevich–Kaganer (DRK) equation. A major advantage of this approach is the possibility of calculating the adsorption equilibrium based on simple physicochemical properties of the adsorptives and on the structural characteristics of the activated carbon. It also appears that, by analogy with adsorption in the vapor phase, a scaling factor can be introduced for adsorption from solution.
Square‐Planar Carbonylchlororhodium(I) Complexes Containing trans‐Spanning Diphosphine Ligands as Catalysts for the Carbonylation of Methanol
Authors: Burger Sylvain , Therrien Bruno , Süss‐Fink Georg 
Published: March 2005

AbstractThe rhodium(I) complexes trans‐[Rh(diphos)(CO)Cl] 7 (diphos=pbpb), 8 (diphos=nbpb), and 9 (diphos=cbpb) were synthesized (Scheme 4) and used as catalysts for the carbonylation of MeOH to AcOH (Scheme 1). The trans coordination imposed by the rigid C‐spacer framework of the diphos ligands pbpb, nbpb, and cbpb, demonstrated by 31P‐NMR and IR spectroscopy of 7–9 and unambiguously confirmed by single‐crystal X‐ray structure analysis of 7, improved the thermal stability of the rhodium(I) system under carbonylation conditions and, hence, the catalytic performance of the complexes. For the catalytic carbonylation of MeOH, the active catalyst could be prepared in situ from the mixture of [Rh(CO)2Cl]2 and the corresponding diphos ligand pbpb, nbpb, or cbpb, giving the same results as carbonylation in the presence of the isolated complexes 7, 8 or 9 (see Table). The highest activity was observed for complex 7 (or the mixture [Rh(CO)2Cl]2/pbpb, the catalytic turnover number (TON) being 950 after 15 min (170°, 22 bar).
Asymmetric Synthesis of Coordination Compounds: Back to the Roots. Diastereoselective Synthesis of Simple Platinum(IV) Complexes
Authors: Drahoňovský Dušan , von Zelewsky Alex 
Published: March 2005

AbstractA publication by Alexander P. Smirnoff in Helvetica Chimica Acta in 1920 [6] describes the first synthesis of a coordination species, i.e., of tris(propane‐1,2‐diamine‐κN1,κN2)platinum(4+) ([PtIV(pn)3]4+), where it was shown that the configuration of a chiral center in the ligand can influence the configuration at the metal. The present investigation of [PtIV(pn)3]4+ was carried out by NMR spectroscopy, where all nuclei in the metal complex were used as sources of information, i.e., 1H, 13C, 15N, and 195Pt. 13C‐NMR and 15N‐NMR spectroscopy (of isotopically enriched complex) were especially informative for the analysis of isomer distribution. Stereoselectivity in the formation reaction of the complexes is rather modest, whereas Δ‐, and Λ‐isomers can be separated efficiently by crystallization. A mixture of [Pt{(S)‐pn}3]4+ and [Pt{(R)‐pn}3]4+ shows no scrambling of the enantiomeric ligands, thus proving the inertness of the complexes.
A Dissociative Route to CH Bond Activation: Ligand Cyclometalation in cis‐Dimethyl[(sulfinyl‐κS)bis[methane]][tris(2‐methylphenyl)phosphine]platinum(2+)
Authors: Romeo Raffaello , Plutino Maria Rosaria , Romeo Andrea 
Published: March 2005

AbstractThe dialkyl compound cis‐dimethyl[(sulfinyl‐κS)bis[methane]][tris(2‐methylphenyl)phosphine]platinum(2+) (cis‐[Pt(Me)2(dmso)(P(o‐tol)3]; 1) has been isolated from the reaction of cis‐dimethylbis[(sulfinyl‐κS)bis[methane]]platinum(2+) (cis‐[Pt(Me)2(dmso)2]) with tris(2‐methylphenyl)phosphane (P(o‐tol)3). Restricted rotation around the PCipso bonds of the phosphane ligand generates two different conformers, 1a and 1b, in rapid exchange in non‐polar solvents at low temperature. Strong through‐space contacts between the ortho‐Me substituent groups on the ligand and the cis‐Me groups in the coordination plane were determined, which proved useful for identifying the atropisomers formed. At room temperature, 1H‐NMR spectra of 1 maintain a ‘static’ pattern upon onset of easy and rapid ortho‐platination, leading to [[2‐[bis(2‐methylphenyl)phosphino‐κP]phenyl]methyl‐κC]methyl[(sulfinyl‐κS)bis[methane]]platinum(2+) (2), a new C,P‐cyclometalated compound of platinum(II), with liberation of methane. The process has been studied by 1H‐ and 31P{1H}‐NMR in CDCl3, and kinetics experiments were performed by conventional spectrophotometric techniques. The first‐order rate constants kc decrease with the addition of dimethyl sulfoxide until the process is blocked by the presence of a sufficient excess of sulfoxide. This behavior reveals a mechanism initiated by ligand dissociation and formation of a three‐coordinate species. The value of the rate constant for dimethyl sulfoxide dissociation k1 has been measured independently over a wide temperature range by both 1H‐NMR ligand exchange (isotopic labeling experiments) and ligand substitution (stopped‐flow pyridine for dimethyl sulfoxide substitution). The rates of the two processes are in reasonable agreement at the same temperature, and a single Eyring plot can be constructed with the two sets of kinetics data. However, the value of the derived dissociation constant at 308 K (k1=6.5±0.3 s−1) is at least two orders of magnitude higher than that of cyclometalation (kc=0.0098±0.0009 s−1 at 308 K). Clearly, the dissociation step is not rate‐determining for cyclometalation. A multistep mechanism consistent with mass‐law retardation is derived, which involves a pre‐equilibrium that controls the concentration of an unsaturated three‐coordinate, 14‐electron T‐shaped cis‐[PtMe2{P(o‐tol)3}] intermediate. Cyclometalation is initiated in this latter by an agostic interaction with the σ(CH) orbital of a methyl group. Oxidative addition of the CH bond follows, yielding a cyclometalated‐hydrido 16‐electron Pt(IV) five‐coordinate intermediate. Finally, reductive elimination and re‐entry of dimethyl sulfoxide with liberation of methane should yield the cyclometalated species 2.
Can the Theoretical Fitting of the Proton‐Nuclear‐Magnetic‐Relaxation‐Dispersion (Proton NMRD) Curves of Paramagnetic Complexes Be Improved by Independent Measurement of Their Self‐Diffusion Coefficients?
Authors: Vander Elst Luce , Sessoye Audrey , Laurent Sophie , Muller Robert N. 
Published: March 2005

AbstractThe self‐diffusion (Dc) coefficients of various lanthanum(III) diamagnetic analogues of open‐chain and macrocyclic complexes of gadolinium used as MRI contrast agents were determined in dilute aqueous solutions (3–31 mM) by pulsed‐field‐gradient (PFG) high‐resolution 1H‐NMR spectroscopy. The self‐diffusion coefficient of H2O (Dw) was obtained for the same samples to derive the relative diffusion constant, a parameter involved in the outersphere paramagnetic‐relaxation mechanism. The results agree with an averaged relative diffusion constant of 2.5 (±0.1)×10−9 and of 3.3 (±0.1)×10−9 m2 s−1 at 25 and 37°, respectively, for 'small' contrast agents (Mr 500–750 g/mol), and with the value of bulk H2O (2.2×10−9 and 2.9×10−9 m2 s−1 at 25° and at 37°, respectively) for larger complexes. The use of the measured values of Dc for the theoretical fitting of proton NMRD curves of gadolinium complexes shows that the rotational correlation times (τR) are very close to those already reported. However, differences in the electronic relaxation time (τSO) at very low field and in the correlation time (τV) related to electronic relaxation were found.
Gadolinium(III) Complexes of dota‐Derived N‐Sulfonylacetamides (H4(dota‐NHSO2R)=10‐{2‐[(R)sulfonylamino]‐2‐oxoethyl}‐1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic Acid): A New Class of Relaxation Agents for Magnetic Resonance Imaging Applications
Authors: Aime Silvio , Botta Mauro , Cravotto Giancarlo , Frullano Luca , Giovenzana Giovanni B. , Geninatti Crich Simonetta , Palmisano Giovanni , Sisti Massimo 
Published: March 2005

AbstractFour new ligands for lanthanide ions based on the H3do3a (=1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic acid) structure and bearing one N‐sulfonylacetamide arm were synthesized, i.e., H4dota‐NHSO2R=10‐{2‐[(R)sulfonylamino]‐2‐oxoethyl}‐1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic acids 1a–e. A 15N‐NMR study of the 15N‐labelled Eu3+ complex of one such ligands, 1d, showed that the coordination of the N‐sulfonylacetamide arm involves the carbonyl O‐atom rather than the N‐atom. The relaxometric properties of the corresponding Gd3+ complexes were investigated as a function of pH and temperature. These complexes have relaxivities in the range 4.5–5.3 mM−1 s−1, at 20 MHz and 25°, and are characterized by a single H2O molecule in their inner coordination sphere. The mean residence lifetime of this molecule is relatively long (500–700 ns) compared to other anionic complexes. The slow rate of H2O exchange can be justified by the extensive delocalization of the negative charge on the N‐sulfonylacetamide arm. The long residence time of the coordinated H2O allowed the observation of the effect of the prototropic exchange on the relaxivity. The study of the interaction between the complex [Gd(1e)]‐ and HSA revealed a weak affinity constant highlighting the importance of a localized negative charge on the complex to promote a strong interaction with the protein.
Complexation Properties of N,N′,N″,N′′′‐[1,4,7,10‐Tetraazacyclododecane‐1,4,7,10‐tetrayltetrakis(1‐oxoethane‐2,1‐diyl)]tetrakis[glycine] (H4dotagl). Equilibrium, Kinetic, and Relaxation Behavior of the Lanthanide(III) Complexes
Authors: Baranyai Zsolt , Brücher Ernő , Iványi Tímea , Király Róbert , Lázár István , Zékány László 
Published: March 2005

AbstractEu3+, Dy3+, and Yb3+ complexes of the dota‐derived tetramide N,N′,N″,N′′′‐[1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetrayltetrakis(1‐oxoethane‐2,1‐diyl)]tetrakis[glycine] (H4dotagl) are potential CEST contrast agents in MRI. In the [Ln(dotagl)] complexes, the Ln3+ ion is in the cage formed by the four ring N‐atoms and the amide O‐atom donor atoms, and a H2O molecule occupies the ninth coordination site. The stability constants of the [Ln(dotagl)] complexes are ca. 10 orders of magnitude lower than those of the [Ln(dota)] analogues (H4dota=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid). The free carboxylate groups in [Ln(dotagl)] are protonated in the pH range 1–5, resulting in mono‐, di‐, tri‐, and tetraprotonated species. Complexes with divalent metals (Mg2+, Ca2+, and Cu2+) are also of relatively low stability. At pH>8, Cu2+ forms a hydroxo complex; however, the amide H‐atom(s) does not dissociate due to the absence of anchor N‐atom(s), which is the result of the rigid structure of the ring. The relaxivities of [Gd(dotagl)] decrease from 10 to 25°, then increase between 30–50°. This unusual trend is interpreted with the low H2O‐exchange rate. The [Ln(dotagl)] complexes form slowly, via the equilibrium formation of a monoprotonated intermediate, which deprotonates and rearranges to the product in a slow, OH−‐catalyzed reaction. The formation rates are lower than those for the corresponding Ln(dota) complexes. The dissociation rate of [Eu(dotagl)] is directly proportional to [H+] (0.1–1.0M HClO4); the proton‐assisted dissociation rate is lower for [Eu(H4dotagl)] (k1=8.1⋅10−6 M−1 s−1) than for [Eu(dota)] (k1=1.4⋅10−5 M−1 s−1).
Structure and Dynamics of Lanthanide Complexes of Triethylenetetramine‐N,N,N′,N″,N′′′,N′′′‐hexaacetic Acid (H6ttha) and of Diamides H4ttha(NHR) Derived from H6ttha as Studied by NMR, NMRD, and EPR
Authors: Zitha‐Bovens Emrin , Muller Robert N. , Laurent Sophie , Vander Elst Luce , Geraldes Carlos F. G. C. , van Bekkum Herman , Peters Joop A. 
Published: March 2005

AbstractA multinuclear NMR study on [Ln(ttha)]3− and [Ln{ttha(NHR)2}]− complexes (R=Et, CH2(CHOH)4CH2OH) shows that coordinating groups of the organic ligands in these complexes are occupying all coordination sites of the metal ions, leaving no space for coordination of H2O molecules (H6ttha=triethylenetetramine‐N,N,N′,N″,N′′′,N′′′‐hexaacetic acid). The lanthanides of the first half of the series bind the ttha‐type ligands in a decadentate fashion, while the complexes formed with the smaller ions of the second half of the lanthanide series are nonadentate. One carboxylate group of the ligand remains unbound in the latter complexes. In principle, the ttha complexes can exist in six enantiomeric forms. Only one of the pair of diastereoisomers can interconvert without decoordination of the ligand. This pair of isomers seems to be predominant in solution. For the [Ln{ttha(NHR)2}]− complexes, the number of chiral centers is larger, resulting in 32 possible enantiomeric forms of the complexes. The NMR spectra of [Nd{ttha(NHEt)2}]− indicate that two dynamic processes occur between the isomers in solution. The NMRD curves of [Gd(ttha)]3−, [Gd{ttha(NHEt)2}]−, and [Gd{ttha(NHgluca)2}]− (NHgluca=D‐glucamine) show significant differences with the previously determined outer‐sphere contributions to the NMRD profiles of the corresponding [Gd{dtpa(NHR)2}]− complexes, which can be ascribed to differences in the parameters determining the electronic relaxation.
Tuning the Properties of Copper(II) Complexes with Tetra‐ and Pentadentate Bispidine (=3,7‐Diazabicyclo[3.3.1]nonane) Ligands
Authors: Comba Peter , Lopez de Laorden Carlos , Pritzkow Hans 
Published: March 2005

AbstractThe synthesis of a series of tetra‐ and pentadentate bispidine‐type ligands (bispidine=3,7‐diazabicyclo[3.3.1]nonane) – tetradentate ligands are donor‐substituted at C(2) and C(4), pentadentate ligands have an additional donor at N(3) or N(7), with pyridine, 2‐methylpyridine, or quinoline donor moieties – and of their CuII complexes are reported, together with single‐crystal structural analyses and solution studies (electrochemistry, electronic and EPR spectroscopy). Depending on the ligand geometry and on the co‐ligands (solvent or counter anion), there are various structural forms (pseudo‐Jahn–Teller elongation along all three molecular axes), and the structural data are correlated with the spectroscopic and electrochemical parameters.
Novel P‐Stereogenic PCP Pincer‐Aryl Ruthenium(II) Complexes and Their Use in the Asymmetric Hydrogen Transfer Reaction of Acetophenone
Authors: Medici Serenella , Gagliardo Marcella , Williams Scott B. , Chase Preston A. , Gladiali Serafino , Lutz Martin , Spek Anthony L. , van Klink Gerard P. M. , van Koten Gerard 
Published: March 2005

AbstractAchiral P‐donor pincer‐aryl ruthenium complexes ([RuCl(PCP)(PPh3)]) 4c,d were synthesized via transcyclometalation reactions by mixing equivalent amounts of [1,3‐phenylenebis(methylene)]bis[diisopropylphosphine] (2c) or [1,3‐phenylenebis(methylene)]bis[diphenylphosphine] (2d) and the N‐donor pincer‐aryl complex [RuCl{2,6‐(Me2NCH2)2C6H3}(PPh3)], (3; Scheme 2). The same synthetic procedure was successfully applied for the preparation of novel chiral P‐donor pincer‐aryl ruthenium complexes [RuCl(P*CP*)(PPh3)] 4a,b by reacting P‐stereogenic pincer‐arenes (S,S)‐[1,3‐phenylenebis(methylene)]bis[(alkyl)(phenyl)phosphines] 2a,b (alkyl=iPr or tBu, P*CHP*) and the complex [RuCl{2,6‐(Me2NCH2)2C6H3}(PPh3)], (3; Scheme 3). The crystal structures of achiral [RuCl(PCP)(PPh3)] 4c and of chiral (S,S)‐[RuCl(PCP)(PPh3)] 4a were determined by X‐ray diffraction (Fig. 3). Achiral [RuCl(PCP)(PPh3)] complexes and chiral [RuCl(P*CP*)(PPh3)] complexes were tested as catalyst in the H‐transfer reduction of acetophenone with propan‐2‐ol. With the chiral complexes, a modest enantioselectivity was obtained.