bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling Transformation: Engaging Objects for Eco‐Social Justice in Design Education
Authors: Zhang Lezhi Crystal 
Published: February 2024

Curriculum design, by its nature, is transformative, molding a progressive and adaptive learning journey.It's clear that climate action and social justice are issues that will require our attention now and in the future. Incorporating object‐based and transformative learning into higher education curricula can lead to the transformative understanding required to tackle these problems.
Culture, Love, and Graphic Design
Authors: Green Daniel 
Published: February 2024

Graphic design's reputation for ephemerality belies its ability to lend substantial physical form to a culture, whether positive or toxic.Graphic design has always told our stories, but what does it have to do with culture or love? A graphic designer shares his views about the relationship so that it can continue to play this role, in a more expansive way, well into the future.
Use of the modified Schirmer test to measure salivary gland hypofunction/hyposalivation: Systematic review and meta‐analysis
Authors: Schoppmeier Christoph Matthias , Janson Malin , Höfer Karolin , Graf Isabelle , Wicht Michael Jochen , Barbe Anna Greta 
Published: February 2024

AbstractAlthough dry mouth is a relatively common condition, salivary flow is not routinely measured in dental clinical practice. Moreover, existing data regarding the use of the modified Schirmer test (MST) for the screening of dry mouth has not been summarized. This systematic review and meta‐analysis, conducted in accordance with the PRISMA guidelines, aimed to determine whether the modified Schirmer test can be used to identify dry mouth. The databases of PubMed, Scopus, ScienceDirect, and CENTRAL (CRD42023393843) were systematically searched to retrieve articles published until 9th November 2023. Among the 343 original articles retrieved, six met the inclusion criteria. A total of 1150 patients, comprising 710 (61.7%) women and 440 (38.3%) men (mean age, 47.1 ± 7.3 years), were included. The meta‐analysis revealed a weak correlation coefficient of = 0.42 (95% Cl: 0.29–0.55) between MST and the unstimulated salivary flow rate. Therefore, while the MST might offer a simple and accessible alternative for initial screening in the future, especially in non‐specialized settings, its variability in sensitivity and specificity, along with an actual lack of standardization, necessitates cautious interpretation. Further studies are necessary before recommending the test in clinical routine.
Concurrent Streptococcus equi subsp. equi infection, purpura haemorrhagica and immune‐mediated myositis in a Quarter Horse filly
Authors: Hepworth‐Warren Kate L. , Young Kimberly A. S. , Armwood Abigail , Roessner Holly , Veerasammy Brittany 
Published: February 2024

SummaryThis report describes a 2‐year‐old Quarter Horse filly that was diagnosed with concurrent Streptococcus equi subsp. equi infection, purpura haemorrhagica, and immune‐mediated myositis. The filly was presented for evaluation of fever of unknown origin, rapid weight loss and inappetence after exposure to strangles that was initially unknown. Over the course of hospitalisation the filly developed mandibular lymphadenopathy, guttural pouch empyema, and mucosal petechiation and ecchymoses. The presence of Streptococcus equi subsp. equi was confirmed via PCR and culture of a lymph node aspirate and biopsies of the skin confirmed leukocytoclastic vasculitis, consistent with purpura haemorrhagica. Genetic testing confirmed that the filly had one copy of the MYH1 mutation (N/My). Following therapy with systemic corticosteroids, plasma transfusion and antimicrobial therapy the filly improved and was discharged. Communication with the owner 11 months later confirmed that filly appeared healthy but remained poorly muscled. This report is the first to the authors' knowledge describing concurrent Streptococcus equi subsp. equi infection, purpura haemorrhagica, and immune‐mediated myositis.
Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network
Authors: Gandolfo Pauline , Soeiro Thomas , Jouve Élisabeth , Revol Bruno , Daveluy Amélie , Bertin Célian , Eiden Céline , Gibaja Valérie , Chaouachi Leila , Pérault‐Pochat Marie‐Christine , Chevallier Cécile , Aquizérate Aurélie , Le Boisselier Reynald , Carton Louise , Lapeyre‐Mestre Maryse , Frauger Élisabeth , Lacroix Clémence , Micallef Joëlle 
Published: February 2024

AbstractBackgroundDue to its psychoactive effects, ketamine has become a drug used for non‐medical purpose.ObjectivesTo assess the latest trends in ketamine use among people with substance use disorder and to characterize its clinical complications using complementary health data sources of the French Addictovigilance Network.MethodsFirst, we extracted all reports involving ketamine from 2012 to 2021 from the database of the OPPIDUM program (i.e., a multicentric program conducted in collaboration with hundreds of substance abuse treatment facilities that collects data on drugs used by subjects with substance use disorders). We described the reports globally and the changes from 2012 to 2021. Second, we extracted all cases involving ketamine from July 2020 to December 2022 from the French National Pharmacovigilance Database (BNPV). We identified the cases related to ketamine use among people with substance use disorder and described them.ResultsThere was a 2.5‐fold increase in the number of ketamine users with substance use disorder in the OPPIDUM program, from 35 (0.7%) subjects in 2012 to 89 (1.7%) subjects in 2021. There was an increase in the proportion of subjects who were daily users, had distress upon discontinuation, and presented addiction. There were 238 cases related to ketamine use among people with substance use disorder in the French National Pharmacovigilance Database from July 2020 to December 2022. Among them, 94 (39.5%) cases involved ketamine use disorder, 20 (8.4%) cases involved urinary tract and kidney symptoms, and 13 (5.5%) cases involved hepatobiliary symptoms.ConclusionThe trend observed over 10 years reflects the growth in ketamine use among people with substance use disorder, although it does not allow to estimate the rates of non‐medical use of ketamine in the general population. Ketamine‐induced uropathy and cholangiopathy are reported in ketamine users with substance use disorder, especially in case of repeated and/or prolonged use of high doses.
Shortening fire return interval predisposes west‐central Canadian boreal peatlands to more rapid vegetation growth and transition to forest cover
Authors: Jones Emily Ann , Chasmer Laura Elizabeth , Devito Kevin John , Hopkinson Christopher Dennis 
Published: February 2024

AbstractClimate change in northern latitudes is increasing the vulnerability of peatlands and the riparian transition zones between peatlands and upland forests (referred to as ecotones) to greater frequency of wildland fires. We examined early post‐fire vegetation regeneration following the 2011 Utikuma complex fire (central Alberta, Canada). This study examined 779 peatlands and adjacent ecotones, covering an area of ~182 km2. Based on the known regional fire history, peatlands that burned in 2011 were stratified into either long return interval (LRI) fire regimes of >80 years (i.e., no recorded prior fire history) or short fire return interval (SRI) of 55 years (i.e., within the boundary of a documented severe fire in 1956). Data from six multitemporal airborne lidar surveys were used to quantify trajectories of vegetation change for 8 years prior to and 8 years following the 2011 fire. To date, no studies have quantified the impacts of post‐fire regeneration following short versus long return interval fires across this broad range of peatlands with variable environmental and post‐fire successional trajectories. We found that SRI peatlands demonstrated more rapid vascular and shrub growth rates, especially in peatland centers, than LRI peatlands. Bogs and fens burned in 1956, and with little vascular vegetation (classified as “open peatlands”) prior to the 2011 fire, experienced the greatest changes. These peatlands tended to transition to vascular/shrub forms following the SRI fire, while open LRI peatlands were not significantly different from pre‐fire conditions. The results of this study suggest the emergence of a positive feedback, where areas experiencing SRI fires in southern boreal peatlands are expected to transition to forested vegetation forms. Along fen edges and within bog centers, SRI fires are expected to reduce local peatland groundwater moisture‐holding capacity and promote favorable conditions for increased fire frequency and severity in the future.
Lurbinectedin in small cell lung cancer: real‐world experience of a multicentre national early access programme
Authors: Alexander Marliese , Rogers Jennifer , Parakh Sagun , Mitchell Paul , Clay Timothy D. , Kao Steven , Hughes Brett G. M. , Itchins Malinda , Kong Benjamin Y. , Pavlakis Nick , Solomon Benjamin J. , John Thomas 
Published: February 2024

AbstractBackground and AimsLurbinectedin is a novel oncogenic transcription inhibitor active in several cancers, including small cell lung cancer (SCLC). We aimed to describe the first Australian experience of the clinical efficacy and tolerability of lurbinectedin for the treatment of SCLC after progression on platinum‐containing therapy.MethodsMulticentre real‐world study of individuals with SCLC initiating lurbinectedin monotherapy (3.2 mg/m2 three‐weekly) on an early access programme between May 2020 and December 2021. Key outcomes were clinical utilisation, efficacy and tolerability. Progression‐free survival (PFS) and overall survival (OS) were calculated using the Kaplan–Meier method. Outcome data were collected within the AUstralian Registry and biObank of thoRacic cAncers (AURORA).ResultsData were analysed for 46 individuals across seven sites. Lurbinectedin was given as second‐ (83%, 38/46) or subsequent‐ (17%, 8/46) line therapy, mostly with prior chemoimmunotherapy (87%, 40/46). We report dose modifications (17%, 8/46), interruptions/delays (24%, 11/46), high‐grade toxicities (28%, 13/46) and hospitalisations (54%, 25/46) during active treatment. The overall response rate was 33% and the disease control rate was 50%. Six‐month OS was 44% (95% confidence interval (CI): 29.0–57.1). Twelve‐month OS was 15% (95% CI: 6.5–26.8). From lurbinectedin first dose, the median PFS was 2.5 months (95% CI: 1.8–2.9) and OS was 4.5 months (95% CI: 3.5–7.2). From SCLC diagnosis, the median OS was 12.9 months (95% CI: 11.0–17.2). Individuals with a longer chemotherapy‐free interval prior to lurbinectedin had longer PFS and OS.ConclusionThis real‐world national experience of lurbinectedin post‐platinum chemotherapy and immunotherapy for individuals with SCLC was similar to that reported in clinical trials.
Northern pikas experience reduced occupancy due to surrounding human land use despite the occurrence of suitable microclimates
Authors: Sakiyama Tomoki , García Molinos Jorge 
Published: February 2024

AbstractAimDespite warming temperatures, some species are found persisting at the trailing edge of their distribution. Microclimates provided by complex topography are considered a key factor in these cases of range stationarity, buffering stress from exposure to warming and enabling persistence. However, for species with trailing‐edges located in human‐modified landscapes, refugial conditions provided by microclimates could be disrupted by human activities. Here, we aimed to understand the determinants of trailing‐edge occupancy for a small lagomorph found in rocky patches harbouring cool microclimates.LocationHokkaido Island, Japan.TaxonNorthern pika (Ochotona hyperborea).MethodsWe surveyed the occupancy of northern pikas across a wide elevational gradient (350–2200 m) for two consecutive summers. Ambient air and microhabitat (i.e. rock interstices) thermal conditions were measured to assess their relationship. We then analysed their effects on occupancy at two nested spatial scales: (1) whole‐distribution, and (2) at identified trailing‐edge sites where we explored the effects of microclimates and surrounding human activities (i.e. distance to nearest road and area of human land use such as plantation forests or agricultural fields).ResultsOverall, rock interstices exhibited cooler conditions than ambient air with temperature differences of 1–2°C. The overall distribution of northern pikas was affected by both mean ambient temperature and microhabitat availability, with warmer (lower elevation) sites with less microhabitats corresponding to the trailing edge of its distribution. Interestingly, trailing edge occupancy patterns were best explained by the negative effect of surrounding human land despite the existence of suitable microclimates in the rocky patches.Main ConclusionsOur findings suggest that the local refugial conditions supported by cool microclimates are likely to be disrupted by the effects of human land alterations at the larger landscape scale. This result highlights the importance of considering the effects of human activities and landscape alteration for effective microrefugia conservation.
Digital health integration for noncommunicable diseases: Comprehensive process mapping for full‐life‐cycle management
Authors: He Tianrui , Cui Wenbin , Feng Yuxuan , Li Xingyi , Yu Guangjun 
Published: February 2024

AbstractAimTo create a systematic digital health process mapping framework for full‐life‐cycle noncommunicable disease management grounded in key stakeholder engagement.MethodsA triphasic, qualitative methodology was employed to construct a process mapping framework for digital noncommunicable disease management in Shanghai, China. The first phase involved desk research to examine current guidance and practices. In the second phase, pivotal stakeholders participated in focus group discussions to identify prevalent digital touchpoints across lifetime noncommunicable disease management. In the final phase, the Delphi technique was used to refine the framework based on expert insights and obtain consensus.ResultsWe identified 60 digital touchpoints across five essential stages of full‐life‐cycle noncommunicable disease management. Most experts acknowledged the rationality and feasibility of these touchpoints.ConclusionsThis study led to the creation of a comprehensive digital health process mapping framework that encompasses the entire life cycle of noncommunicable disease management. The insights gained emphasize the importance of a systemic strategic, person‐centered approach over a fragmented, purely technocentric approach. We recommend that healthcare professionals use this framework as a linchpin for efficient disease management and seamless technology incorporation in clinical practice.
Plasma tryptophan pathway metabolites quantified by liquid chromatography‐tandem mass spectrometry as biomarkers in neuroendocrine tumor patients
Authors: Johansen S. U. , Hansen T. , Nordborg A. , Meyer R. , Goll R. , Florholmen J. , Jensen E. 
Published: February 2024

AbstractA good and accessible biomarker is of great clinical value in neuroendocrine tumor (NET) patients, especially considering its frequently indolent nature and long‐term follow‐up. Plasma chromogranin A (CgA) and 5‐hydroxyindoleacetic acid (5‐HIAA) are currently used as biomarkers in NET, but their sensitivity and specificity are restricted. 5‐HIAA is the main metabolite of serotonin, an important neurotransmitter of the tryptophan pathway. The aim of this study is to estabish a sensitive and accurate method for the quantification of tryptophan pathway metabolites in plasma. We further aimed to evaluate its utility as a clinical tool in NET disease. We obtained plasma samples from NET patients and healthy controls recruited from the University Hospital of North Norway, Tromsø. Samples were analyzed by liquid chromatography‐tandem mass spectrometry (LC–MS/MS), and eight metabolites of the tryptophan pathway were quantified. We included 130 NET patients (72/130 small intestinal [SI] NET, 35/130 pancreatic NET, 23/130 other origin) and 20 healthy controls. In the SI‐NET group, 26/72 patients presented with symptoms of carcinoid syndrome (CS). We found that combining tryptophan metabolites into a serotonin/kynurenine pathway ratio improved diagnostic sensitivity (92.3%) and specificity (100%) in detecting CS patients from healthy controls compared with plasma 5‐HIAA alone (sensitivity 84.6%/specificity 100%). Further, a clinical marker based on the combination of plasma serotonin, 5‐HIAA, and 5OH‐tryptophan, increased diagnostic capacity identifying NET patients with metastasized disease from healthy controls compared with singular plasma 5‐HIAA, serotonin, or CgA. In addition, this marker was positive in 61% of curatively operated SI‐NET patients compared with only 10% of healthy controls (p < .001). Our results indicate that simultaneous quantification of several tryptophan metabolites in plasma, using LC–MS/MS, may represent a clinically useful diagnostic tool in NET disease.
Exploring facial overfilled syndrome from the perspective of anatomy and the mismatched delivery of fillers
Authors: Lim Ting‐Song , Wanitphakdeedecha Rungsima , Yi Kyu‐Ho 
Published: February 2024

AbstractIntroductionFacial fillers and injectables have transformed the landscape of cosmetic procedures, offering rejuvenation possibilities. However, the emergence of “Facial Overfilled Syndrome (FOS)” presents a concerning trend attributed to excessive filler use and suboptimal injection techniques. Understanding the interplay between facial aging and augmentation techniques is crucial in addressing and preventing FOS.Material and MethodsFacial overfilled syndrome is characterized by the excessive use of fillers, resulting in a distorted and heavy appearance. It manifests in various forms, including 'flowerhorn' foreheads, 'sunset' eyes, 'chipmunk' cheeks, 'witch' chins, and 'pillow' faces. The syndrome arises from attempts to combat anatomical aging with dramatic filler treatments, causing rapid volume changes and skin tightening. Skeletal structures and soft tissue distribution across different ethnicities play a significant role in FOS development.ResultsUnderstanding the aging process across facial tissues is essential, as fillers cannot entirely reverse aging manifestations. Tailored assessment and treatment plans should precede filler injections, involving muscle assessment, observation of facial movements during injection, and ultrasound imaging of fat layers. Attention should be given to filler pressure and migration risks, particularly in areas with elevated pressure. Additionally, alternative approaches like energy‐based devices and polymer reinforcement of facial ligaments should be considered to minimize filler use. Ethnic variations in facial anatomy require careful consideration to avoid overcorrection.ConclusionFOS predominantly affects individuals of East Asian descent due to specific facial characteristics. Prevention strategies involve minimizing filler use, addressing underlying bone changes, and considering ethnic and gender differences in facial anatomy. Recent MRI and ultrasound studies challenge the notion of filler breakdown, emphasizing the importance of filler selection and injection techniques. Education, individualized treatments, and a holistic understanding of facial anatomy are key to preventing and managing FOS and ensuring natural and harmonious facial aesthetics.
Prescriptive Theorizing to Tackle Societal Grand Challenges: Promises and Perils
Authors: Wickert Christopher 
Published: February 2024

AbstractDescriptive and prescriptive theorizing are two sides of the same coin and fundamentally complementary, if not reciprocal in their relationship. Both have a place in management theorizing, yet this Point‐Counterpoint debate takes issue with how they are currently performed in research. The Point makes the case for prescriptive theorizing to help tackle societal grand challenges and meaningfully impact practice, and it offers a recipe for doing this on a solid normative foundation. The Counterpoint cautions against the impact that such prescriptions may have and calls for more contextualized approaches. In this introduction to the debate, I intend to take the conversation that both the Point and Counterpoint have provoked even further by highlighting some under‐emphasized but important theoretical avenues to examine the (un)intended consequences of both prescriptive and descriptive theorizing; namely by mobilizing research on performativity and counter‐performativity.
A family member's death increases religious activity: Evidence from Germany
Authors: Friehe Tim , Pfeifer Christian 
Published: February 2024

AbstractReligiosity influences economic behavior in various domains, but what determines religiosity? Using data from the representative Socio‐Economic Panel Study for Germany (SOEP), this paper shows that religious activity increases after a family member's death. The life event's effect is larger after a partner's death when compared to a parent's death. Our results indicate that the influence of a family member's death on religious activity is temporary and are consistent with the religious coping hypothesis.
Examination of workload perception, burnout, and perceived organizational support in emergency healthcare professionals: A structural equation model
Authors: Doğan Aysun , Ertuğrul Bekir , Akin Kutay 
Published: February 2024

AbstractJob stress is one of the important factors affecting employee behavior. One of the most important factors in reducing burnout caused by stress is organizational support. In this context, the aim of this study is to identify the moderating role of perceived organizational support in the effect of workload perception on burnout within the emergency healthcare professionals’ universe. The data for this study were collected from 703 health professionals working in emergency health services in three major cities of Turkey. The relationships and the model of the study is analyzed by the Structural Equation Model technique. The results indicate that perceived workload is a factor that causes employee burnout, and perceived organizational support is a factor that reduces employee burnout. This study contributes to researchers and health managers by revealing the importance of workload planning and organizational activities that support employees to reduce burnout in health workers.
Development and evolution of the Asteraceae capitulum
Authors: Zhang Teng , Elomaa Paula 
Published: February 2024

SummaryAsteraceae represent one of the largest and most diverse families of plants. The evolutionary success of this family has largely been contributed to their unique inflorescences, capitula that mimic solitary flowers but are typically aggregates of multiple florets. Here, we summarize the recent molecular and genetic level studies that have promoted our understanding of the development and evolution of capitula. We focus on new results on patterning of the enlarged meristem resulting in the iconic phyllotactic arrangement of florets in Fibonacci numbers of spirals. We also summarize the current understanding of the genetic networks regulating the characteristic reproductive traits in the family such as floral dimorphism and differentiation of highly specialized floral organs. So far, developmental studies in Asteraceae are still limited to a very narrow selection of model species. Along with the recent advancements in genomics and phylogenomics, Asteraceae and its relatives provide an outstanding model clade for extended evo‐devo studies to exploit the morphological diversity and the underlying molecular networks and to translate this knowledge to the breeding of the key crops in the family.