bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic analysis of nipple aspirate fluid using SELDI‐TOF‐MS
Authors: Sauter Edward R. , Shan Sumei , Hewett John E. , Speckman Paul , Du Bois Garrett C. 
Published: December 2004

AbstractProteomic analysis of body fluids, including breast nipple aspirate fluid (NAF), holds promise to aid in early cancer detection. We conducted a prospective trial that collected NAF from women scheduled for diagnostic breast surgery to determine 1) the consistency of proteomic results, 2) protein masses associated with breast cancer, 3) subsets of women with a unique proteomic profile and 4) a breast cancer predictive model. NAF was collected preoperatively in 114 women and analyzed by SELDI‐TOF mass spectrometry over a 3–50 kDa range using H4, NP and SAX ProteinChips. For all 3 chips, the same protein peaks were detected over 90% of the time in duplicate samples. The overall coefficient of variation was ≤ 0.17% for each chip for the internal standard and ≤ 0.29% for the unknown proteins. Seven candidate protein ion masses frequently expressed in NAF were identified. Three (5,200‐H4, p=.04, 11,880‐H4, p=.07 and 13,880 Da‐SAX, p=.03) were differentially expressed in women with/without breast cancer. Protein expression differed between women with/without pathologic nipple discharge (PND), but the 5,200, 11,880 and 13,880 proteins remained associated with breast cancer even if PND samples were excluded. Subset analysis identified differences in expression between benign disease and DCIS and between DCIS and invasive cancer for the 5,200 and 33,400 Da proteins. The best cancer detection model included age, parity and the 11,880 Da protein, and excluded women with PND. 1) NAF proteomic analysis using SELDI‐TOF is reproducible with the same sample set across different platforms, 2) differential proteomic expression exists between women/without breast cancer and 3) combining proteomic and clinical information that are available before surgery optimizes the prediction of which women have breast cancer. © 2004 Wiley‐Liss, Inc.
Retracted: Transactivation of the CCL5/RANTES gene by Epstein‐Barr virus latent membrane protein 1
Authors: Uchihara Jun‐Nosuke , Krensky Alan M. , Matsuda Takehiro , Kawakami Hirochika , Okudaira Taeko , Masuda Masato , Ohta Takao , Takasu Nobuyuki , Mori Naoki 
Published: December 2004

AbstractRetraction: The following article has been retracted through agreement between the first author and several coauthors, the journal Editor‐in‐Chief, Peter Lichter, and John Wiley & Sons, Ltd.: Uchihara JN, Krensky AM, Matsuda T, Kawakami H, Okudaira T, Masuda M, Ohta T, Takasu N, Mori N. (2006). Transactivation of the CCL5/RANTES gene by Epstein‐Barr virus latent membrane protein 1. Int J Cancer; 118 (February (5)): 747‐755 published online on 17 DEC 2004 in Wiley Online Library (www.onlinelibrary.wiley.com). After an investigation the retraction has been agreed due to inappropriate duplication of images and overlap with other published work.
Dietary patterns and risk of pancreatic cancer
Authors: Nkondjock André , Krewski Daniel , Johnson Kenneth C. , Ghadirian Parviz ,   Canadian Cancer Registries Epidemiology Research Group
Published: December 2004

AbstractTo investigate associations between broad dietary patterns and pancreatic cancer risk, we conducted a case‐control study of 585 histologically confirmed pancreatic cancer cases and 4,779 population‐based controls in 8 Canadian provinces between 1994 and 1997. Dietary intake was assessed using a FFQ. Major dietary patterns were identified by factor analysis. Unconditional logistic regression was used to describe associations between dietary pattern scores and risk of pancreatic cancer. Three dietary patterns were identified: Western, characterized by high intake of processed meats, sweets and desserts, refined grains and potatoes; fruits and vegetables, characterized by high intake of fresh fruits and cruciferous vegetables; drinker, characterized by high consumption of liquor, wine and beer. After adjustment for age, BMI, smoking, physical activity, province, educational attainment and total energy intake, the fruits and vegetables pattern was associated with a 49% reduction in pancreatic risk among men (OR = 0.51, 95% CI 0.29–0.90, p = 0.004) when comparing the highest and lowest quartiles of dietary pattern scores. No significant relationship was observed with the Western and drinker patterns. Although the response rate for eligible, recruited subjects was relatively low, our results suggest that the fruits and vegetables dietary pattern reduces pancreatic cancer risk among men. © 2004 Wiley‐Liss, Inc.
Experimental model for observation of micromotion in cell culture
Authors: Lewandowska‐Szumieł Małgorzata , Sikorski Krzysztof , Szummer Andrzej , Komender Janusz , Kowalski Marcin , Daniels A. U. 
Published: December 2004

AbstractIt is known that the micromotion between implant and bone inhibits direct bone growth either on or into implant surfaces in vivo. Nevertheless, biocompatibility tests in vitro of biomaterials for bone/implant interfaces are mainly performed under static conditions. This work describes a dynamic, in vitro experimental simulation of the effect of mutual, small‐scale implant surface–tissue displacement on adhered cells. Disks of simulated tissue (PVP hydrogel) were subjected to cyclic micromotion ranging from 0 at the center to 1000 μm at the periphery at ∼ 13 Hz, relative to biomaterial surfaces or tissue culture polystyrene controls populated with human osteoblasts in standard tissue culture plate wells. The effect of the interfacial micromotion on the number of cells remaining attached was quantitated by XTT assay. The activity level of the remaining cells was determined by an alkaline phosphatase assay, and cell stress was evaluated by nitrogen assay. Significantly more cells (ANOVA) became detached from similarly prepared surfaces of titanium, hydroxyapatite, and alumina compared to the polystyrene control, and detachment from alumina was greater than for the other two materials. The activity of the remaining attached cells was lower as compared to the static (no micromotion) control but not significantly different among the biomaterials. All nitrogen assays were negative, suggesting minimal cell stress occurred. The method is proposed as a useful and discriminating in vitro tool for biocompatibility studies focused on cell adhesion to biomaterials under conditions related to those which exist at the implant/bone interface in vivo, and it allows subsequent studies of the still‐viable cells by other methods. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 379–387, 2005
Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency
Authors: Barker Brad , Altuntas Fevzi , Paranjape Geeta , Sarode Ravindra 
Published: December 2004

AbstractIn patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post‐exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery. J. Clin. Apheresis 19:208–210, 2004. © 2004 Wiley‐Liss, Inc.
Registering the Amica electronic structure code in the Extensible Computational Chemistry Environment
Authors: Gdanitz Robert J. , Black Gary D. , Lansing Carina S. , Palmer Bruce J. , Schuchardt Karen L. 
Published: December 2004

AbstractWe describe the integration and use of the Amica software package (“Atoms & Molecules In Chemical Accuracy”) within the Extensible Computational Chemistry Environment (Ecce). Amica is capable of accurately solving the electronic Schrödinger equation of small atoms and molecules using terms that are linear in the interelectronic distances, r12, on multireference level of theory, but it requires expert knowledge to configure and execute its algorithms. Ecce is a comprehensive suite of tools that support the computational chemistry research processes of computation setup, execution, and analysis through a convenient graphical user interface. Additionally, Ecce was architected with mechanisms to integrate alternative electronic structure codes. The successful integration of Amica within Ecce validates the architecture of the latter and brings the high‐accuracy capabilities of Amica to a wider audience. © 2004 Wiley Periodicals, Inc. J Comput Chem 26: 214–225, 2005
Feedback to clinicians: Theory, research, and practice
Authors: Sapyta Jeffrey , Riemer Manuel , Bickman Leonard 
Published: December 2004

AbstractDespite the dearth of consistent evidence for conventional feedback mechanisms in clinical practice, the primary methods of feedback for clinicians remain supervision and clinical experience. A new research approach, known as patient‐focused research, provides clinicians with direct feedback regarding a client's health status and relative progress in therapy. This article briefly reviews the relation of different types of feedback (i.e., supervision, clinical experience, feedback on client health status) to clinical outcome. In contrast to the mixed results for clinical experience and supervision, providing client health status feedback to clinicians significantly improves outcome, especially for clients who are not doing well in therapy. We conclude with a description of a model that provides insight into ways that feedback interventions can work best for professionals. Characteristics of the clinician, the feedback format, and the dissonance between feedback and clinician goals all relate to the ways that feedback is interpreted and utilized. © 2004 Wiley Periodicals, Inc. J Clin Psychol/In Session.
Removal of Methylene Blue from aqueous solutions using as biosorbent Sargassum muticum: an invasive macroalga in Europe
Authors: Rubin Eugenia , Rodriguez Pilar , Herrero Roberto , Cremades Javier , Barbara Ignacio , Sastre de Vicente Manuel E 
Published: December 2004

AbstractMethylene Blue adsorption on Sargassum muticum, an invasive macroalga in Europe, has been investigated using visible absorption spectroscopy. Different pre‐treatments, protonation and chemical cross‐linking with CaCl2 or H2CO, have been tested in order to improve the stability as well as the adsorption capacity of the algal biomass. The equilibrium binding has been described in terms of Langmuir or Freundlich isotherms depending on the algal pre‐treatment; from the maximum adsorption capacity values, an estimation of the algal specific surface area was made. Moreover, it has been found that adsorption kinetics can be described according to the first order Lagergren model, from which the rate constant and the adsorption capacity were determined. Finally, simple empirical equations were obtained to evaluate the amount of Methylene Blue removed at any initial concentration and reaction time. The results obtained have shown that this type of material has a high adsorption capacity for Methylene Blue dye, this feature together with the short times needed to reach the equilibrium suggest that Sargassum muticum can be used as a low‐cost biosorbent in wastewater treatments. Copyright © 2004 Society of Chemical Industry
CoGalois groups as metric spaces
Authors: Enochs Edgar , Estrada Sergio 
Published: December 2004

AbstractThe coGalois group associated to a torsion free cover of a ℤ‐module are known to have a canonical topology. In this paper we will see that this topology can be deduced by pk‐roots of elements of coGalois groups over ℤp (p is a prime). We shall investigate in the metric associated to this topology and deduce that the coGalois groups are complete and are isomorphic as metric spaces to products of Banach spaces having orthonormal bases over the various rings of p‐adic integers. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Second‐order boundary value problems with nonhomogeneous boundary conditions (I)
Authors: Kong Lingju , Kong Qingkai 
Published: December 2004

AbstractWe study the nonlinear boundary value problem with nonhomogeneous multi‐point boundary condition

Sufficient conditions are found for the existence of solutions of the problem based on the existence of lower and upper solutions with certain relation. Using this existence result, under some assumptions, we obtain explicit ranges of values of λ1 and λ2 with which the problem has a solution, has a positive solution, and has no solution, respectively. Furthermore, we prove that the whole plane for λ1 and λ2 can be divided into two disjoint connected regions ΛE and ΛN such that the problem has a solution for (λ1, λ2) ∈ ΛE and has no solution for (λ1, λ2) ∈ ΛN. We also show that under different assumptions, the problem has a solution for all (λ1, λ2) ∈ ℝ2. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Adult‐onset chorea and mitochondrial cytopathy
Authors: Caer Morgane , Viala Karine , Levy Richard , Maisonobe Thierry , Chochon Florence , Lombès Agnès , Agid Yves 
Published: December 2004

AbstractWe report on 2 adult patients presenting with choreic movements as the main clinical feature of mitochondrial cytopathy. One patient exhibited a sensory neuronopathy and ophthalmoplegia. The other had ptosis, a proximal myopathy, and a sensory neuropathy. The diagnosis of mitochondrial cytopathy was established by the presence of ragged red fibers, cytochrome C oxydase‐negative fibers, and a defect of the complex IV of the respiratory chain in muscle biopsy. No mutations in mitochondrial DNA were detected. The choreic movements observed in juvenile forms of mitochondrial cytopathy are rarely observed in adults. Although striatal vulnerability is commonly reported in patients with mitochondrial disorders, the mechanism by which the mitochondrial dysfunction leads to chorea is not known. © 2004 Movement Disorder Society
Existence of positive periodic solution for the electron beam focusing system
Authors: Zhang Meiyue , Chen Taiyong , Liu Wenbin , Jia Yong 
Published: December 2004

AbstractIn this paper, we study the mathematical model of electron beam focusing system

where a>0,b⩾0 are constants, find conditions for the existence of positive π‐periodic solution of the above equation by using analytical method and comparison theory, and prove the existence of positive π‐periodic solution by the continuously dependent theory of initial value problem. Copyright © 2004 John Wiley & Sons, Ltd.
In situ generated diphenylsiloxane‐polyimide adduct‐based nanocomposites
Authors: Goswami Manisha G. , Singh Rahul , Tiwari Atul , Nema S.K. 
Published: December 2004

AbstractArylsiloxane was incorporated into polyimide (PI) via electronic interaction with polyamic acid (PAA)/PI, and a wide spectrum of properties were evaluated for different compositions. The samples prepared with relatively low concentrations (0.0001–0.1%) of oligomers showed unusual synergism, which is attributed to the generation of nanostructures dispersed in the continuous PI matrix. The incorporation of siloxane with bulky phenyl groups contributed to enhanced thermal stability as determined by thermogravimetric analysis. Water uptake and methanol absorption by these composites were evaluated and correlated with the underlying micro‐ and nanostructures. Fourier Transform Infrared (FTIR) spectroscopy was used to elucidate the probable reaction mechanism (including in situ polymerization of arylsilanol), and to study the synthetic aspects associated with the molecular composites and nanocomposites formation. POLYM. ENG. SCI., 45:142–152, 2005. © 2004 Society of Plastics Engineers
Barrier and mechanical properties of injection molded montmorillonite/polyesteramide nanocomposites
Authors: Krook M. , Morgan G. , Hedenqvist M.S. 
Published: December 2004

AbstractProperties of injection‐molded biodegradable polyesteramide composites containing 5 and 13 wt% octadecylammonium‐treated montmorillonite clay have been studied. Oxygen transmission rates and mechanical properties were measured. X‐ray diffraction was used to assess the degree of intercalation of the clay layer stacks, and transmission electron microscopy (TEM) was used to assess the morphology and degree of layer delamination. A substantial reduction in oxygen permeability was observed when clay was added to the composites. The oxygen permeability of the 13 wt% clay sample was only 20% of that of the pure polymer. The in‐plane stiffness and in‐plane strength of the sheets were greatly improved without any embrittlement. These beneficial effects were probably due to the high degree of clay layer exfoliation and orientation observed by TEM. Heat shrinkage, toughness analysis, and cutting operations suggested that the polymer chains and the clay layers were oriented parallel to the plane of the sheet. TEM and X‐ray showed that stacked layers were still present but that these were significantly intercalated. The clay‐layer periodic spacing increased from 25 Å to approximately 35 Å during processing. POLYM. ENG. SCI. 45:135–141, 2005. © 2004 Society of Plastics Engineers
High‐power ultrasonic treatment of butyl rubber gum: Structure and properties
Authors: Feng Wenlai , Isayev A. I. 
Published: December 2004

AbstractThe ultrasonic treatment of butyl rubber gum during extrusion with a grooved‐barrel ultrasonic reactor was carried out at a mean residence time of 3.6 s and at different ultrasonic amplitudes. Gel permeation chromatography, NMR spectroscopy, differential scanning calorimetry, thermogravimetric analysis, and dynamic and mechanical property measurements were performed. The changes in the structure, curing behavior, and physical properties of the gum were found to be highly dependent on the applied ultrasonic amplitude. In particular, the molecular weight of the treated gum decreased and the molecular weight distribution increased with the ultrasonic amplitude. The number of double bonds in the ultrasonically treated gum was less than that in the virgin gum. The dynamic properties of the ultrasonically treated gums also indicated the occurrence of degradation during the ultrasonic treatment. The tensile strength and modulus of the vulcanizates prepared from the treated gums were reduced in comparison with those of the virgin vulcanizate because of degradation. In contrast, the elongation at break was higher. However, no significant changes in the thermal stability between the virgin and treated gums and among the vulcanizates were observed. © 2004 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 334–344, 2005
Mechanism of persistent luminescence in Sr2MgSi2O7:Eu2+; Dy3+
Authors: Dorenbos P. 
Published: December 2004

AbstractA recently developed method to determine the energy levels of divalent lanthanide ions relative to the conduction band and valence band of host compounds is applied to Sr2MgSi2O7 doped with Eu2+ and Dy3+. The level locations are not consistent with the widely adopted and generally believed mechanism of persistent luminescence in Eu2+ and Dy3+ doped aluminates and silicates. A new mechanism of persistent luminescence is proposed. In this mechanism Eu3+ and Dy2+ are the stable trapping centers and not Eu+ and Dy4+ as in the existing mechanism. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide
Authors: Mossa Jaber S. , El‐Feraly Farouk S. , Muhammad Ilias 
Published: December 2004

AbstractThe synergistic activity of antimycobacterial constituents from Saudi plants was evaluated in combination with isonicotinic acid hydrazide (INH) against four atypical organisms, namely, Mycobacterium intracellulare, M. smegmatis, M. xenopei and M. chelonei. The potency of INH was increased four‐fold, using an in vitro checkerboard method, against each mycobacteria when tested with a subtoxic concentration of the totarol, isolated from J. procera. The MIC values of totarol, ferulenol (from Ferula communis) and plumbagin (from Plumbago zeylanica) were thus lowered from 1.25–2.5 to 0.15–0.3 µg/mL due to synergism with INH. When tested against the resistant strain of M. tuberculosis H37Rv, plumbagin and 7β‐hydroxyabieta‐8,13‐dien‐11,12‐dione exhibited inhibitory activity at <12.5 µg/mL, while others were inactive at this concentration. Copyright © 2004 John Wiley & Sons, Ltd.
Antibacterial activity of phytochemicals isolated from Erythrina zeyheri against vancomycin‐resistant enterococci and their combinations with vancomycin
Authors: Sato M. , Tanaka H. , Oh‐Uchi T. , Fukai T. , Etoh H. , Yamaguchi R. 
Published: December 2004

AbstractSix phytochemicals were isolated from the roots of Erythrina zeyheri (Leguminosae) by repeated silica gel column chromatography using various eluting solvents. Extensive spectroscopic studies revealed that all were isoﬂavonoids. The antibacterial activity of the six compounds against vancomycin‐resistant enterococci (VRE) was estimated by determining the minimum inhibitory concentration (MIC). Of the six isoﬂavonoids, erybraedin A ((6aR, 11aR)‐3,9‐dihydroxy‐4,10‐di(γ,γ‐dimethylallyl)pterocarpan) exhibited the highest growth inhibitory potency against VRE with an MIC value of 1.56–3.13 µg/mL, followed by eryzerin C ((3R)‐7,2′,4′‐trihydroxy‐6,8‐di(γ,γ‐dimethylallyl)isoﬂavan) (MIC 6.25 µg/mL). These compounds also inhibited the growth of methicillin‐resistant Staphylococcus aureus (MRSA) at 3.13–6.25 µg/mL. The antibacterial effects of the two compounds against VRE and MRSA were based on bacteriostatic action. When erybraedin A or eryzerin C was combined with vancomycin, the fractional inhibitory concentration (FIC) index against VRE ranged from 0.5306 to 1.0 and from 0.5153 to 0.75, respectively. The combinations also showed FIC indices of 0.6125–1.0 against MRSA. The results indicate that, depending on the case, both compounds act either synergistically or additively with vancomycin against VRE and MRSA. Erybraedin A and eryzerin C show evidence of being potent phytotherapeutic agents against infections caused by VRE and MRSA. Copyright © 2004 John Wiley & Sons, Ltd.
Inhibition of platelet phospholipase A2 activity by catuaba extract suggests antiinﬂammatory properties
Authors: Barbosa Nádia R. , Fischmann Lygia , Talib Leda L. , Gattaz Wagner F. 
Published: December 2004

AbstractIn the inﬂammation process, phospholipase A2 (PLA2) catalyses the cleavage of the sn‐2 ester‐linked fatty acids from phospholipids, being the enzyme responsible for arachidonic acid (AA) release by cells for the biosynthesis of the prostaglandins and thromboxanes via the cyclooxygenase system, and the leukotrienes and eicosatetraenoids via the lipoxygenase pathway. AA mobilization by PLA2 and subsequent prostaglandins synthesis is considered to be a pivotal event in inﬂammation. Therefore, drugs that inhibit PLA2, thus blocking the COX and LOX pathways in the AA cascade, may be effective in the treatment of inﬂammatory processes. New strategies for the treatment of inﬂammatory processes could be detected by a search for active principles of vegetal origin that control the lipid mediator production by inhibition of PLA2. The present data are part of a wide explorative investigation on the effects of Trichilia catigua (catuaba), which found that PLA2 activity was totally inhibited by catuaba at a concentration of 120 µg/mL, suggesting that this natural substance may have antiinﬂammatory properties. Copyright © 2004 John Wiley & Sons, Ltd.