bluuebunny/crossref_metadata_2025_split huggingface dataset:
From risk communication about asymptomatic atherosclerosis to cognitive and emotional reactions and lifestyle modification
Authors: Andersson Elin M. , Lindvall Kristina , Wennberg Patrik , Johansson Helene , Nordin Steven 
Published: January 2024

Abstract
Background
Non-adherence in the general population to preventive guidelines on cardiovascular disease calls for an interdisciplinary approach acknowledging psychological factors of relevance for risk communication and lifestyle modification. Evidence is building up regarding the advantage of sharing arterial imaging evidence of subclinical atherosclerosis with asymptomatic individuals, but there is limited understanding of how this relates to mechanisms of importance for behavioural change. Longitudinal studies on associations between patients’ reactions and lifestyle modification are missing. The population-based randomized controlled trial VIPVIZA investigates the impact of pictorial information about subclinical atherosclerosis, added to traditional risk factor-based communication. The intervention includes a personalized, colour-coded and age-related risk communication strategy and a motivational conversation, and has been shown to reduce cardiovascular disease risk.

Methods
In the present study we assessed cognitive and emotional reactions to the intervention, and how these reactions are associated to lifestyle modification. The participants’ evaluation of the risk communication was assessed in the intervention group (n = 1749). Lifestyle modification was assessed with a lifestyle index based on physical activity, diet, smoking and alcohol consumption at baseline and after 3 years. Associations between cognitive and emotional response and lifestyle modification were tested with analyses of covariance in a subset of participants (n = 714–857).

Results
The intervention increased understanding of personal CVD risk, the possibility to influence the risk, and how to influence the risk. Severity of atherosclerosis was associated with emotional reactions, but emotions of strong negative valence were uncommon. Cognitive response and emotional arousal evoked by the intervention were positively associated with lifestyle modification, whereas negative emotions in isolation were not. High level of cognitive response in combination with high level of emotional arousal was found to be most beneficial for lifestyle modification.

Conclusions
The results demonstrate the potential of communicating asymptomatic atherosclerosis with a pictorial, colour-coded and age-related strategy, also including a motivational conversation. Furthermore, the results show the importance of CVD risk communication evoking engagement, and that an interaction between cognitive and emotional reactions might be central for sustained lifestyle modification. Our results also indicate that, in an asymptomatic population, atherosclerosis screening may strengthen disease prevention and health promotion.

Trial registration
ClinicalTrials.gov identifier: NCT01849575. Registration date 08/05/2013.
Robots for surgeons? Surgeons for robots? Exploring the acceptance of robotic surgery in the light of attitudes and trust in robots
Authors: Szabó Balázs , Őrsi Balázs , Csukonyi Csilla 
Published: January 2024

Abstract
Background
Over the last century, technological progress has been tremendous, and technological advancement is reflected in the development of medicine. This research assessed attitudes towards surgical robots and identified correlations with willingness to participate in robotic surgery based on factors influencing trust in automated systems.

Method
Using data from a survey, which included the Multi-dimensional Robot Attitude Scale (MdRAS) and a questionnaire consisting of attitude statements regarding the factors affecting trust in automated systems, the experiment assessed the attitudes of healthcare workers and potential patients towards surgery robots, and attempted to find a correlation between these attitudes, age, and gender.

Results and Conclusion
Statistical evaluation of the responses (N = 197) showed that positive attitude towards surgical robots showed a high correlation with the willingness to participate in robotic surgery and gave the strongest correlations with the MdRAS utility and negative attitude towards robots subscales. For the assessment of willingness, the MdRAS subscales alone did not provide a strong enough correlation. All factors examined showed a significant correlation with participation. Having faith in the surgery robot, the propensity to trust technology, the designer’s reputation, the ease of work that a surgical robot provides, positive experience with robots, and believing the surgeon is competent at operating the machine seemed to have been the most important positive correlations, while fear of errors gave the highest negative correlation. The healthcare workers and potential patients showed significant differences in the subscales of the questionnaire perceived risk and knowledge but no significant difference in the characteristics of the surgical robot. There was no difference in willingness to participate between the samples. Age did not show a significant correlation with the score achieved and willingness in any of the samples. Significant differences were found between male and female respondents, with men having more positive attitudes and being more likely to participate in surgeries using surgery robots than women. As a result, the research potentially sheds light on the factors that need to be considered when building trust in robotic surgery.
Association of common variant rs9934336 of SLC5A2 (SGLT2) gene with SARS-CoV-2 infection and mortality
Authors: Das Anamika , Dhangadamajhi Gunanidhi 
Published: January 2024

AbstractCOVID-19 has its life-threatening complications more pronounced in people with underlying health conditions such as diabetes, cardiovascular disease and kidney disease. Inhibition of the sodiumglucose cotransporter 2 (SGLT2), which primarily increases urinary glucose excretion, is shown to be beneficial in patients with type 2 diabetes mellitus (T2D) and other comorbidities. SGLT2 is encoded by SLC5A2 gene, and of the several genetic variants, SNP rs9934336 is gaining importance for being associated with reduced HbA1c level and lower incidence of T2D. Since a complex bidirectional relationship exists between COVID-19 and hyperglycaemia, we conducted a worldwide association study to investigate the effect of rs9934336 on COVID-19 outcomes. Worldwide prevalence data of SLC5A2 SNP rs9934336 were obtained from relevant published articles and databases for genomic variants. COVID-19 data procured from the Worldometer website were used for conducting Spearman’s correlation analysis with minor allele frequency data of rs9934336. Significant positive correlation was observed between rs9934336 and COVID-19 incidence (p < 0.0001, r = 0.6225) as well as deaths (p < 0.0001, r = 0.5837). The present finding of significant association of SLC5A2 variant rs9934336 with COVID-19 risk has to be validated by case–control studies in diverse populations along with other variants regulating the expression and function of SGLT2.
Trauma, mind and brain: the impact of war on mental health
Authors: Maercker A. 
Published: January 2024

Abstract
The PTSD diagnosis was in 1980 largely facilitated by consequences of the Vietnam War. Since then, there have been hundreds of other war-related conflicts in the world. My presentation will distinguish between war-related trauma effects on military personnel (where most research has been done) and on civilians, distinguishing effects on children/adolescents, adults and older people. I will answer the question, how do war-related trauma sequelae differ from other man-made or accidental traumas? Further, I will address the issue of whether “moral injury” research in military personnel after wartime operations is also relevant to similar phenomena in civilian populations traumatised by war? Which of the brain-related research approaches (localisation, network connectivity, altered RDoC functions) are particularly relevant in this context? Finally, emerging research priorities related to the current war of invasion against Ukraine will be addressed.

Disclosure of Interest
None Declared
On the screening, diagnosis, and treatment of adolescent and adult ADHD patients with comorbid substance use: international guidelines
Authors: Crunelle C. L. 
Published: January 2024

Abstract
Attention deficit/hyperactivity disorder (ADHD) often co-occurs with substance use disorders (SUD). Together, these disorders are associated with significantly more burden for patients and society, than each alone. Patients with SUD and underlying ADHD have more complex SUD and have more poly-substance use compared with SUD patients without ADHD. A correct identification of ADHD in adult and adolescent individuals with SUD remains important regarding treatment, treatment effectiveness, and treatment retention.
Several screening tools are available and have been validated in individuals with ADHD and comorbid SUD. It is highly recommended that these are used routinely, followed by an ADHD diagnostic process initiated as soon as possible. While several treatment options are accessible, randomized controlled trials show only limited effect sizes of standard pharmacotherapy in adult and adolescent ADHD patients with comorbid SUD. Simultaneous and integrated treatment, with a combination of pharmacotherapy and psychotherapy and for both ADHD and SUD, should preferably be initiated.
We present an overview of the current international guidelines on screening, diagnosis and treatment of ADHD adults and adolescents with comorbid substance use disorders.

Disclosure of Interest
None Declared
COLOR PERCEPTION IN DIFFERENT LANGUAGES AND CULTURES (BASED ON THE FRENCH AND GERMAN LANGIAGE MATERIALS)
Authors: Chaiko Natalja N. , Murieva Meri V. 
Published: January 2024

Purpose. This paper is devoted to consideration of the color terms in French and German idioms and paremias and determining specifics of color perception in both languages. The authors made a comprehensive analysis of French and German idioms and paremias which contain color components. Color lexics containing such colors as blue/azure, red, green, yellow, white and black serves as the object of the analysis. Color palette clearly reflects cultural diversity, a worldview of French and German people.
Method and methodology of the work. The study is based on comparative and descriptive method and method of thematical analysis of lexical units.
Results. The results of the conducted research let us to conclude that color terms in both French and German languages are quite diverse from the national-cultural perspective and convey a high degree of intensity. Color perception is grounded on emotional impressions. All the color terms considered in the current article have positive as well as negative assessment, more rarely neutral.
Practical implications. The outcomes of the study can be used in teaching lexicology, phraseology, stylistics, as well as within the field of linguistic and cultural studies of France and Germany.
ON STYLISTIC AND SEMANTIC-STYLISTIC SYNONYMS IN THE EVEN LANGUAGE
Authors: Nesterova Elena V. 
Published: January 2024

The lexicon of the Even language is extremely understudied. The choice of the topic of this paper is conditioned by the necessity to cover the undeveloped issues on synonyms of Even language with regard to their sources; semantic and typological features. The present work is devoted to the study of stylistic synonymy in the Even language.
Purpose. To identify the resources of stylistic synonymy, highlight stylistic and semantic-stylistic synonyms, as well as define their features.
Materials and methods. The research is based on the descriptive method, the techniques of linguistic observation, generalisation and interpretation are used. The source of the study is the "Even-Russian dictionary" by V.A. Robbek, M.E.
Robbek.
Results. The paper is the first to define and distribute words with stylistic meaning as well as to single out the type of semantic-stylistic synonyms and to give a description of stylistic synonyms in the Even language. The sources of these types of synonyms are words of dialect, folklore, ritual and colloquial lexicon.
Practical implications. The results of the work can be applied in researches on the languages of the Manchu-Tungus peoples.
A povoada língua de Eros
Authors: Victorio Filho Aldo , Braga Motta de Paula Nathan 
Published: January 2024

ResumoO jogo entre imagem e palavra, encarado aqui como uma possível tradução do Eros, dá indícios da tensão entre o que se pode nomear, ainda que se escape, e o que está posto à posteriori da linguagem.Palavras-chave: Língua, Eros, Linguagem, Fotografia. AbstractThe game between image and word, seen here as a possible translation of Eros, gives indications of the tension between what can be named, even if it escapes, and what is placed a posteriori in language.Keywords: Language, Eros, Language, Photography.
Multiple paradoxical embolisms caused by central venous catheter thrombus passing through a patent foramen ovale: A case report
Authors: Li Jian-Duan , Xu Nian , Zhao Qiang , Li Biao , Li Li 
Published: January 2024

BACKGROUND
To date, this is the first case of a paradoxical embolism (PDE) that concurrently manifested in the coronary and lower limb arteries and was secondary to a central venous catheter (CVC) thrombus via a patent foramen ovale (PFO).
CASE SUMMARY
Here, we report a case of simultaneous coronary and lower limb artery embolism in a PFO patient carrier of a CVC. The patient presented to the hospital with acute chest pain and lower limb fatigue. Doppler ultrasound showed a large thrombus in the right internal jugular vein, precisely at the tip of the CVC. Transthoracic and transesophageal echocardiography confirmed the existence of a PFO, with inducible right-to-left shunting by the Valsalva maneuver. The patient was administered an extended course of anticoagulation therapy, and then the CVC was successfully removed. Percutaneous PFO closure was not undertaken. There was no recurrence during follow-up.
CONCLUSION
Thus, CVC-associated thrombosis is a potential source for multiple PDE in PFO patients.
ANTIRADICAL ACTIVITY OF WATER-ALCOHOL EXTRACTS OF RHODODENDRON ADAMSII R., GROWING IN YAKUTIA
Authors: Zykova Irina Dement'yevna , Naimushina Liliya Viktorovna , Efremov Aleksandr Alekseyevich 
Published: January 2024

Classes of extractive substances of rhododendron Adams, growing in the Republic of Sakha (Yakutia), contained in an aqueous extract and extracts based on 20, 40, 70 and 95% ethyl alcohol were studied. It is shown that these are mainly phenolic compounds, tannins and flavonoids. Moreover, the maximum amount of them is contained in an extract based on 40% ethyl alcohol.
The HPLC method revealed the presence of chlorogenic, caffeic, gallic acids, rutin, quercetin and dihydroquercitin in extracts.
In model reactions with a free stable 2,2-diphenyl-1-picrylhydrazyl radical, the antiradical properties of water-alcohol solutions of Adams rhododendron were studied. The results of the DPPH test showed that the antiradical activity (ARA) is minimal for an extract based on 95% alcohol and increases from 46.7% in the case of an aqueous extract to 60.2% for a 40% aqueous alcohol extract, which is due to the peculiarity of their chemical composition. It is shown that the antiradical activity of extracts correlates well with the content of phenolic compounds in their composition (correlation coefficient 0.98).
According to the size of the ARA, water-alcohol extracts can be arranged in the following row: 40% extract > 20% extract > 70% water-alcohol extract > water extract > 95% alcohol extract.
The impact of supply chain risk and supply chain integration on organizational performance
Authors: Malik Tahir , Hassan Syed Mehmood , Tufail Muhammad 
Published: January 2024

Goal: The purpose of this study is to investigate the mediating role of supply chain integration for Supply chain risks heading toward organizational performance. This study is mainly focused on the dairy sector of emerging economies.
Design / Methodology / Approach: This is quantitative research, in which a multi-item scale web-based survey was conducted to collect primary data. 407 stakeholders of the dairy industry, specifically the customers and the ones dealing with supply chain operations and the planning and integration department were investigated. Confirmatory factor analysis and internal consistency were applied to test the reliability and fitness of the measurement model and structural equation modeling-SEM is used to test the proposed hypotheses.
Results: The results suggest that in the dairy sector, both customer and supplier risks, act as barriers to implementing (SCI) supply chain integration and also negatively influence (OP) organizational performance. However, supplier risks, belonging to the dairy industry of an agricultural-based country like Pakistan, have a comparatively less negative impact on organizational performance as compared to customer risk, conversely, supply chain integration helps the organization to achieve better performance. The integration indeed acts as a strong mediator in reducing the negative impact of supply chain risk.
Limitations of the investigation: This study utilizes cross-sectional data, which restricts the researchers to depict the entire manifestation of (SCR) supply chain risk, supply chain integration, and organization performance, for businesses operating in the dairy sector of a developing economy, like Pakistan.
Practical implications: This study helps managers to use SCI as a tool to reduce the impact of supply chain risk i.e. supplier risk and customer risk on organizational performance. Also, this study explains the importance of customer risk as compared to supplier risk associated with perishable products.
Originality / Value: This paper enriches the literature in an evolving area of SCI and SCR, by investigating the mediating role of SCI. Two key risks i.e. supplier risk and customer risk associated with the supply chain network of dairy sector organizations are addressed, along with the mediating ability of supply chain integration to improve firm performance is investigated.
PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications
Authors: Wang Xiangyan , Lu Hao , Rong Jun , Sun Zhongjie , Zheng Yanhua , Fan Bolin , Jia Ziming 
Published: January 2024

Abstract
The growing prevalence of hyperuricemia necessitates the urgent development of more potent treatments. This study aimed to develop, optimize, and evaluate the safety and efficacy of porcine–human recombinant uricase (PHRU) both in vitro and in vivo. The study employed gene editing of PHRU through site-directed mutagenesis, with recombinant proteins expressed in vitro utilizing Escherichia coli. The polyethylene glycol (PEG) approach was employed to augment uricase stability and diminish immunogenicity. The pharmacokinetics and pharmacodynamics of PHRU were tested in vitro and in Sprague Dawley rats. Successful expression of the fusion protein in E. coli and the development of the PEGylated drug were achieved. In vitro experiments confirmed the efficacy of PEG-PHRU in degrading uric acid, with PEGylation not markedly affecting the biological activity of PHRU. Animal studies revealed that PEG-PHRU significantly lowered plasma uric acid levels and mitigated hyperuricemia-induced renal damage in rats. Both drug metabolism and pharmacokinetics exhibited favorable characteristics without observable adverse effects in experimental animals. This novel fusion protein shows the potential for ameliorating hyperuricemia and related renal complications, highlighting it as a promising drug candidate with substantial market applications.
A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation
Authors: Gosset Christian , Foguenne Jacques , Simul Mickaël , Layios Nathalie , Massion Paul B. , Damas Pierre , Gothot André 
Published: January 2024

Abstract

Objectives
This study was undertaken to assess CD91 expression on monocytes and changes in monocyte subset distribution during acute tissue damage and bloodstream infection (BSI).

Methods
We investigated blood specimens from healthy individuals, trauma and cardiac surgery patients as a model of tissue damage, and patients with BSI, by flow cytometry using a panel of antibodies comprising CD45, HLA-DR, CD14, CD16 and CD91 for the identification of monocyte subsets.

Results
While infrequent in healthy subjects, CD91low/neg monocyte levels were markedly high in BSI, trauma and after cardiac surgery. This monocyte subset expanded up to 15-fold in both patient cohorts, whereas CD14+CD16+ inflammatory monocytes were multiplied by a factor of 5 only. CD14+CD91low monocytes displayed a significantly lower density of HLA-DR and markedly reduced expression of CD300e, compared to the other subsets. They also expressed high levels of myeloperoxidase and showed robust phagocytic and oxidative burst activity.

Conclusions
Expansion of CD91low monocytes is a sensitive marker of acute inflammatory states of infectious and non-infectious etiology.
Der Raum lehrt. Hermann Hesses Bildungsroman im Licht der Qiao-Yiologie
Authors: Meng Guofeng 
Published: January 2024

Zusammenfassung
Im Rahmen der Qiao-Yiologie wird in diesem Beitrag anhand der Analyse verschiedener Räume in Hermann Hesses Bildungsromanen – namentlich des Flusses in Siddhartha, der Pestepidemie in Narziß und Goldmund sowie des Bambusgehölzes in Das Glasperlenspiel – aufgezeigt, dass der junge Protagonist die Akkumulation von Erkenntnissen sowie die geistige Erhebung (Yi) in einem bestimmten Raum auf seinem Entwicklungsweg (Qiao) erreicht. In Verbindung mit der zweidimensionalen Qiao-Yi-Konstruktion werden folgende Schlussfolgerungen gezogen: Die erzieherische Funktion des Raums ist nicht nur Ausdruck des I Ging und der taoistischen Konzepte von Yin und Yang, sondern auch eine Bekräftigung des menschlichen Geistes in der harmonischen Resonanz zwischen Menschen und Objekten. Obwohl diese Räume ihre pädagogische Funktion in unterschiedlichen Formen erfüllen, haben sie dieselben kulturellen und anthropologischen Implikationen.