bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH BOS PADA PENGELUARAN PENDIDIKAN SISWA TINGKAT SEKOLAH DASAR DI KABUPATEN GIANYAR
Authors: I Wayan Juliana Yoga Anggara Putra 
Published: January 2024

Tujuan penelitian ini adalah untuk Mengidentifikasi permasalahan dana BOS (Bantuan Operasional Sekolah) dan untuk mengetahui pengaruh BOS terhadap pengeluaran pendidikan siswa tingkat Sekolah Dasar di Kabupaten Gianyar. Populasi dalam penelitian ini adalah jumlah sekolah dasar (SD) di Kabupaten Gianyar yaitu sebanyak 295 sekolah dasar pada tahun 2020. Jumlah sampel dihitung dengan rumus slovin maka didapatkan jumlah sampel pada sekolah dasar (SD) di kabupaten Gianyar yang akan diambil dalam penelitian ini adalah sebanyak 75 sampel. Teknik analisis data yang digunakan terdiri dari Analisis Deskriptif dan Analisis Manova (Multivariate Analysis of Variance). Hasil analisis menunjukkan bahwa terdapat berbagai macam masalah teknis yang terjadi dalam dana BOS pada tingkat Sekolah Dasar di Kabupaten Gianyar yaitu adanya penggunaan dana bos kadang tidak sesuai dengan kebutuhan sekolah, Dana Bos datangnya tidak tepat waktu dan pelaporannya harus segera selesai serta terlalu banyak ada perubahan, Penyusunan RKAS yang harus sesuai dengan ambang batas harga yang sudah ditentukan. Hasil uji Multivariate Analysis of Variance (Manova) menunjukkan keempat nilai p-value pada kategori lokasi sekolah memperoleh nilai signifikansi 0,000<0,05, maka disimpulkan bahwa adanya perbedaan pengeluaran pendidikan berdasarkan lokasi pada level kepercayaan 95% antara pengaruh Program dana BOS (Bantuan Operasional Sekolah) terhadap pengeluaran pendidikan berlandaskan kategori lokasi sekolah dan status sekolah.
Kata Kunci: Program BOS, pengeluaran pendidikan, Sekolah Dasar, Gianyar
KESEJAHTERAAN LANJUT USIA DAN BEBERAPA FAKTOR PENENTUNYA DI KECAMATAN DENPASAR SELATAN
Authors: Arissuhandana I Wayan Yogi , Yasa I Gusti Wayan Murjana 
Published: January 2024

The elderly population generally begins to experience a decline in both physical and psychological health, but they still hope for a better life welfare possibility. The objectives to be achieved in this research are: 1) To analyze the effect of family social support, health, work status and education level simultaneously on the welfare of the elderly in South Denpasar District. 2) To analyze the effect of family social support, health, work status and education level partially on the welfare of the elderly in South Denpasar District. 3) To find out how high the level of elderly welfare in South Denpasar District.The population in this study were residents aged 60 years and over who live in South Denpasar District and the sample used the Slovin formula as many as 100 elderly people. This research uses nonrandom sampling technique, which then the sample is taken by accidental sampling. The analysis technique used is multiple linear regression analysis. The results of the study found that the welfare level of the elderly population in South Denpasar District was classified as very high. Simultaneously, family social support, health access, work status and education level affect the welfare of the elderly population in South Denpasar District. Partially family social support, health access, work status and education level have a positive and significant effect on the welfare of the elderly population in South Denpasar District.

Keywords: Elderly welfare, family social support, health access, work status and education level
PENGARUH INFLASI, KURS DOLAR AS, DAN IJEPA TERHADAP EKSPOR TEKSTIL PAKAIAN JADI INDONESIA KE JEPANG
Authors: Rismayanti Ni Made Dwi , Setiawina Nyoman Djinar 
Published: January 2024

Indonesia is an agrarian country that makes the non-oil and gas sector as a mainstay sector in trade in this non-oil and gas sector whose influence in trade is industrial commodities such as those that enter into non-oil and gas exports consist of textile commodities apparel whose main purpose of export is Japan, and to facilitate international trade made international trade agreements one of which is between Indonesia and Japan known as Indonesia-Japan Economic Partnership Agreement (IJEPA). Based on the results of research and analysis can be concluded that simultaneously variable Inflation, EXCHANGE Rate OF US Dollar and IJEPA has a significant effect on the Export Value of Textile Apparel Indonesia. Inflation partially negatively affects the export value of Indonesian Apparel Textiles, while the EXCHANGE Rate of US Dollar and IJEPA has a significant positive effect on The Export of Indonesian Apparel Textiles. Variable Exchange Rate US Dollar has a more dominant influence on the value of Textile Exports Finished Clothing Indonesia than other free variables namely variable Inflation and IJEPA.
Keywords :Inflation, US Dollar Exchange Rate, IJEPA, Export Value of Apparel Textiles Klasifikasi JEL: E31, F21, F53, C67
PENGARUH TINGKAT PENDIDIKAN, UPAH MINIMUM DAN PERTUMBUHAN EKONOMI TERHADAP TINGKAT PENGANGGURAN DI WILAYAH SARBAGITA
Authors: Cahyani Mei , Marhaeni AnakAgung 
Published: January 2024

Pengangguran adalah suatu kondisi seseorang yang tidak memiliki pekerjaan atau yang sedang mencari pekerjaan namun belum mendapatkan pekerjaan. Pengangguran merupakan masalah ekonomi yang sering terjadi yang dipengaruhi oleh berbagai faktor. Pengangguran terjadi akibat banyaknya angkatan kerja belum memperoleh pekerjaan karena lapangan pekerjaan kurang memadai. Tingkat pengangguran merupakan persentase angkatan kerja yang sedang mencari pekerjaan. Penelitian ini bertujuan: 1) Untuk menganalisis pengaruh simultan tingkat pendidikan, upah minimum, dan pertumbuhan ekonomi terhadap tingkat pengangguran di Wilayah Sarbagita; 2) Untuk menganalisis pengaruh parsial tingkat pendidikan, upah minimum, dan pertumbuhan ekonomi terhadap tingkat pengangguran di Wilayah Sarbagita; dan 3) Untuk menganalisis variabel yang memiliki pengaruh dominan terhadap tingkat pengangguran di Wilayah Sarbagita.
Data yang digunakan adalah data sekunder dengan tipe data panel yaitu kombinasi data time series sebanyak 9 tahun dari tahun 2011-2019 dan data cross section sebanyak 1 kota dan 3 kabupaten (Kota Denpasar, Kabupaten Badung, Kabupaten Gianyar, dan Kabupaten Tabanan) yang bersumber dari Badan Pusat Statistik Provinsi Bali dengan jumlah pengamatan sebanyak 36 pengamatan. Jenis data yang digunakan adalah data kuantitatif dan data kualitatif, kemudian data diolah dengan teknik analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa: 1) Tingkat pendidikan, upah minimum, dan pertumbuhan ekonomi secara simultan berpengaruh signifikan terhadap tingkat pengangguran; 2) Tingkat pendidikan tidak berpengaruh terhadap tingkat pengangguran. Pertumbuhan ekonomi dan upah minimum secara parsial berpengaruh negatif dan signifikan terhadap tingkat pengangguran; dan 3) Variabel yang memiliki pengaruh dominan terhadap tingkat pengangguran di Wilayah Sarbagita adalah upah minimum.
Kata kunci: tingkat pengangguran, tingkat pendidikan, upah minimum, pertumbuhan ekonomi
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI NILAI KURS DOLLAR AMERIKA PADA MASA SEBELUM DAN SAAT PANDEMI COVID-19 DI INDONESIA
Authors: Mahendra I Wayan Yoga Praditya , Widanta Anak Agung Bagus Putu 
Published: January 2024

The economic life of a country cannot be separated from the state of the foreign economy. The purpose of this study is to analyze the influence of the Covid-19 pandemic, interest rates, inflation, and net exports simultaneously and partially on the US dollar exchange rate. This research was conducted in Indonesia. The type of data used is quantitative in the form of associative. Data collection methods using indirect observation. This study uses a non-participant observation method which is calculated by taking 15 months before the pandemic (December 2018 – February 2020), and 15 months during the pandemic (March 2020 – May 2021) so that the sample size in this study is 30. data analysis used in this research is multiple linear regression analysis. The results of data analysis show that the results of simultaneous testing show that the Covid-19 pandemic, interest rates, inflation, and net exports simultaneously have a significant effect on the US dollar exchange rate. The Covid-19 pandemic and inflation partially had a positive and significant effect on the US dollar exchange rate, while interest rates and net exports partially had a positive but not significant effect on the US dollar exchange rate. It is hoped that the government can make policies and become one of the evaluation materials to maintain exchange rate stability.
Keywords : Covid-19, Inflation, Interest Rate.Net Export,Exchange Rate
PENGARUH BELANJA MODAL DAN PENDIDIKAN TERHADAP PERTUMBUHAN EKONOMI DAN KEMISKINAN DI KABUPATEN/KOTA PROVINSI BALI
Authors: Wicaksono Fauzan Yudo 
Published: January 2024

Setiap negara akan berusaha untuk mencapai keberhasilan pembangunan dengan meningkatkan pertumbuhan ekonomi semaksimal mungkin dan mengentaskan kemiskinan yang dialami masyarakat ekonomi rendah.Tujuan yang hendak dicapai dalam penelitian ini adalah untuk menganalisis belanja modal dan pendidikan terhadap pertumbuhan ekonomi di Kabupaten/Kota Provinsi Bali; untuk menganalisis pengaruh belanja modal, pendidikan dan pertumbuhan ekonomi terhadap kemiskinan di Kabupaten/Kota Provinsi Bali; dan untuk mengetahui apakah belanja modal dan pendidikan berpengaruh tidak langsung terhadap kemiskinan melalui pertumbuhan ekonomi di Kabupaten/Kota Provinsi Bali. Jumlah pengamatan dalam penelitian ini adalah sebesar 45 data dengan metode pengumpulan data melalui studi pustaka Teknik Analisis yang digunakan dalam penelitian ini adalah Path Analysis. Hasil dari penelitian ini yaitu; belanja modal dan pendidikan secara langsung tidak berpengaruh terhadap pertumbuhan ekonomi di Kabupaten/Kota Provinsi Bali tahun 2016-2020; belanja modal dan pendidikan secara langsung berpengaruh negatif dan signifikan terhadap kemiskinan di Kabupaten/Kota Provinsi Bali tahun 2016-2020, sedangkan pertumbuhan ekonomi secara langsung tidak berpengaruh terhadap kemiskinan di Kabupaten/Kota Provinsi Bali tahun 2016-2020; dan pertumbuhan ekonomi bukan sebagai variabel intervening pengaruh belanja modal dan pendidikan terhadap kemiskinan di Kabupaten/Kota Provinsi Bali tahun 2016-2020.
PENGARUH PRODUKSI, KONSUMSI DAN HARGA KEDELAI NASIONAL TERHADAP IMPOR KEDELAI DI INDONESIA
Authors: Assifah Puteri 
Published: January 2024

In comparison to the major soybean-producing nations in the globe, Indonesia's soybean production is still in a relatively early stage of development. The demand for domestic agricultural products is rising along with the population growth and rising per capita consumption. There is a gap between the demand for and supply of domestic agricultural products as a result of the rising demand for agricultural products not being met by rising local soybean production.
Time series analysis is a quantitative method used in this study. Data was collected between 2010 and 2019.
According to the study's findings, neither consumption nor production have an impact on imports. While imports of soybeans are impacted by the price variable.
KARAKTERISTIK BLOK PLASTIK BAHAN PASANGAN DINDING (BPBPD) MENGGUNAKAN MINYAK JELANTAH DAN PLASTIK TIPIS BEKAS KEMASAN DENGAN MATERIAL PENGISI AGREGAT ALAM
Authors: Mataram I Nyoman Karnata , Thanaya I Nyoman Arya , Manurung Edwin Christiansen 
Published: January 2024

Produksi sampah terus meningkat seiring pertumbuhan penduduk. Sampah plastik tipis bekas kemasan, dan minyak jelantah merupakan beberapa diantaranya. Material ini dapat dijadikan blok plastik bahan pasangan dinding (BPBPD). Tujuan penelitian ini adalah untuk menganalisis karakteristik BPBPD menggunakan minyak jelantah, plastik tipis bekas kemasan, dan agregat alam. Penelitian ini menggunakan tiga tipe campuran yaitu campuran tipe A (Minyak + Plastik Kresek), campuran tipe B (Minyak + Plastik Berlapis Aluminium) dan campuran tipe C (Minyak + Plastik Tipis Selain A dan B) dengan tambahan agregat pada setiap campuran. Setelah percobaan proporsi campuran, diperoleh proporsi campuran paling kental yang dapat diaduk secara manual, yaitu 250gr plastik bekas: 250gr minyak jelantah: 1000gr agregat, untuk membuat satu sampel 100x100x(80-95)mm. Pembuatan sampel diawali dengan memanaskan minyak jelantah pada temperatur 200°C, kemudian cacahan dengan ukuran sekitar 0,5-20mm dituangkan/dilelehkan lalu ditambahkan agregat dan diaduk rata secara manual, kemudian dicetak dengan cetakan metal. Lelehan plastik dipadatkan dengan dua tumbukan alat tumbuk Marshall pada temperatur ideal 125-110°C, untuk memberi efek pemampatan ringan dan perataan permukaan. Sampel didinginkan dan dikeluarkan dari cetakan kemudian diuji. Diperoleh tingkat penyerapan awal (Initial Rate of Suction-IRS) berkisar antara 0,0119-0,0833 kg/m2.menit; penyerapan air berkisar 1,59-3,93%; porositas antara 1,041-1,819%. Kuat tekan tanpa rendaman rata-rata tiap variasi campuran A, B, dan C berturut-turut 42,49; 5,61; 5,95 kg/cm2, setelah perendaman berturut-turut 30,93; 4,25; 3,40 kg/cm2. Secara umum kuat tekan BPBPD A dengan rendaman memenuhi syarat kuat tekan minimum bata beton pejal menurut Standar Nasional Indonesia (SNI-03-0349-1989) mutu IV (=25 kg/cm2), sebanding dengan bahan dinding kuat tekan rendah lainnya.
Normalización de la violencia en redes sociales: un estudio de casos con adolescentes costarricenses
Authors: García Martínez José Antonio , Castaño Benavides Alejandra , Herra Chaves Marcela , Fallas Vargas Manuel Arturo , Villalobos Zamora Natalia 
Published: January 2024

El uso cada vez más extendido de la tecnología y las redes sociales entre adolescentes implica la exposición a diferentes tipos de violencia. El objetivo de este estudio es comprender la influencia de las redes sociales en la normalización de la violencia en adolescentes costarricenses. Con un enfoque cualitativo y un método desde la sociología digital a través de estudios de caso, se llevaron a cabo grupos focales y entrevistas a profundidad con cinco estudiantes de noveno año de un colegio de la provincia de Heredia, Costa Rica. A través de un proceso inductivo, se concluye que aunque las redes sociales por sí mismas no determinan el desarrollo de procesos de normalización de la violencia, al ser una extensión social del entorno físico se consolidan como un canal de exposición a la violencia observada y experimentada. Igualmente, se tornan en espacios de resignificación desde los cuales se podrían estar invisibilizando, legitimando y normalizando algunas manifestaciones de la violencia.

Normalization of violence on social media: a case study with Costa Rican adolescents
Abstract
The increasingly widespread use of technology and social media among adolescents involves exposure to different types of violence. The objective of this study is to understand the influence of social media in the normalization of violence among Costa Rican adolescents. Using a qualitative approach and from digital sociology and through the method of case studies, focus groups and in-depth interviews were conducted with five ninth-grade students from a school in the province of Heredia. Through an inductive process, it was concluded that although social media, by themselves, do not determine the development of processes of normalization of violence, they consolidate as a channel of exposure to observed and experienced violence, as they are a social extension of the physical environment. Likewise, they become spaces of resignification from which some manifestations of violence could be invisibilized, legitimized, and normalized.
تأثير استخدام القصص التعليمية في إرساء بعض مهارات الجمناستك الفني لأطفال الروضة بعمر (5 سنوات )
Authors: كريم فاطمة 
Published: January 2024

تكون قصص الاطفال التعليمية مترابطة وتحاكي الواقع وغنية بالمعلومات التي تساهم في تثقيف الطفل وتعليمه وتتميز بأسلوب تجديدي تشويقي , فيأنس الطفل إليها ويستجيب لمضامينها ويخرج بكل قصه من تعلم شيء جديد يساهم في رقيه وتثقيفه تعتبر القصة التعليمية هي أقرب مدخل الى نفسية الطفل ,الارساء هو عملية لربط حالة معينة من الشعور بمثير ايجابي بحيث يتم ربط ذلك المثير باستجابة تتناسب مع المثير وبصورة تعكس الحالة الشعورية للطفل أما مشكلة البحث نظرا لخبرة الباحثة في متابعة العملية التعليمية من خلال درس التربية الرياضية في الروضة وعدم إعطاءه الاهتمام الكافي في إشباع رغبة الاطفال في هذه المرحلة العمرية ، الأمر الذي دفع الباحثة إلى إيجاد حلا لهذه المشكلة من خلال تأثير القصص التعليمية في إرساء مهارات الجمناستك الفني لأطفال الروضة بعمر (5 سنوات ) ويهدف البحث إعداد مجموعة من القصص التعليمية وتأثيرها في إرساء بعض مهارات الجمناستك الفني لأطفال الروضة بعمر (5 سنوات)و التعرف على تأثير القصص التعليمية في إرساء بعض مهارات الجمناستك الفني لأطفال الروضة بعمر(5 سنوات ) وكان فرضا البحث هناك فروق معنوية بين الاختبارات القبلية والبعدية ولصالح الاختبارات البعدية للمجموعة التجريبية في تأثير القصص التعليمية في إرساء بعض مهارات الجمناستك الفني لأطفال الروضة بعمر(5 سنوات ) هناك فروق معنوية بين المجموعتين التجريبية والضابطة في الاختبارات البعدية في تأثير القصص التعليمية في إرساء بعض مهارات الجمناستك الفني لأطفال الروضة بعمر(5 سنوات ) استخدمت الباحثة المنهج التجريبي لملائمته لطبيعة البحث تحدد مجتمع البحث بإطفال روضة براعم الازهار الاهلية في بغداد وتم تقسيمهم بالطريقة العشوائية البسيطة إلى مجموعتين تجريبية وضابطة وبواقع (10) تلميذ لكل مجموعة , واستخدمت الباحثة الحقيبة الاحصائية (spss) لمعالجة نتائج البحث إحصائياً , ضرورة دعم القصة التعليمية وترسيخ هذا الجنس الأدبي في العملية التعليمية مع ضرورة استخدام الارساء في مناهج التعلم الاخرى .
Primary Cutaneous Follicle Center Lymphoma in an Adult African American Male
Authors: Arreola Amanda , Gower Andraya , Allen Pamela , Brady Joshua , Shendrik Igor 
Published: January 2024

Primary cutaneous B-Cell Lymphomas (PCBCL) is a form of a lymphoproliferative neoplasm consisting of proliferation localized to the skin. Cutaneous lymphomas originate from mature T-lymphocytes, B-lymphocytes, or NK cells. The incidence of PCBCL is significantly lower in patients with Skin of Color (SoC) and is quite rare among African American (AA) individuals, compared to their Caucasian counterparts. The clinical course of PCFCL in SoC is not widely studied or reported in literature due to the low incidence in the AA population. We present a case of PCBCL in an AA individual along with a brief review of the clinical presentation, pathology, and treatment options of the condition. According to the U.S. Census Bureau, approximately half of the U.S population will have SoC by 2050; by adding our case of PCFCL to the body of literature, we hope to promote awareness of the presentation and course of this cutaneous disorder in SoC patients.
Bimekizumab Efficacy in Patients with Moderate to Severe Plaque Psoriasis and Hypertension, Elevated Body Mass Index, or Hyperglycemia: Results Through 3 years of Treatment in 5 Phase 3/3b Trials
Authors: Armstrong April , Feldman Steven R. , Gisondi Paolo , Ståhle Mona , Davis Leah , Wiegratz Susanne , Cross Nancy , Mrowietz Ulrich 
Published: January 2024

Introduction: Patients with moderate to severe plaque psoriasis have a higher risk of cardiometabolic comorbidities than the general population.1,2 Here, response to bimekizumab (BKZ) in psoriasis patients with hypertension, elevated body mass index (BMI), or hyperglycemia at baseline is reported through 3 years of treatment.
Procedure/study: Data were pooled from the following trials: BE SURE, BE VIVID, BE READY, their open-label extension (OLE) BE BRIGHT, and BE RADIANT.3–7 Included patients received BKZ 320 mg every 4 weeks (Q4W) to Week 16, then Q4W or Q8W in the maintenance period and on OLE entry. All received BKZ Q8W from Week 64 (BE RADIANT)/OLE Week 48 (BE BRIGHT) or next scheduled visit (dose groups were combined in this analysis). Psoriasis Area and Severity Index (PASI) ≤2, ≥90% improvement from baseline in PASI (PASI 90), and PASI 100 responses were evaluated in patients with psoriasis and concurrent hypertension (systolic >130 mmHg or diastolic >85 mmHg), elevated BMI (>30 kg/m2), or hyperglycemia (≥140 mg/dL or ≥7.8 mmol/L), based on objective laboratory measurements at baseline. Data are reported using modified non-responder imputation: patients who discontinued due to lack of efficacy or treatment-related adverse events were considered non-responders at subsequent timepoints; multiple imputation was used for all other missing data.
Results: Of 1,107 BKZ-randomized patients who entered the OLEs, 546, 493, and 81 had hypertension, elevated BMI, and hyperglycemia at baseline, respectively. At Week 16, 91.3% of all BKZ-treated patients had PASI ≤2; high response rates were also observed in patients with hypertension (88.9%), elevated BMI (87.8%), and hyperglycemia (87.7%). At Year 3 (OLE Week 96), PASI ≤2 response rates were 91.3% (all patients), 90.0% (hypertension), 89.4% (elevated BMI), and 91.1% (hyperglycemia). At Week 16, 90.9%/65.5% of all BKZ-treated patients achieved PASI 90/100; high responses were also observed in patients with hypertension (89.0%/62.8%), elevated BMI (87.6%/60.3%), and hyperglycemia (86.4%/64.2%). At Year 3, PASI 90/100 response rates were 90.7%/70.0% (all patients), 89.3%/66.3% (hypertension), 89.2%/66.2% (elevated BMI), and 87.9%/57.7% (hyperglycemia).
Conclusion: High levels of complete/near-complete skin clearance achieved at Week 16 were durable through 3 years’ BKZ treatment in psoriasis patients, including those who had baseline hypertension, elevated BMI, or hyperglycemia.
Funding: UCB Pharma.
Efficacy Comparison of Targeted Systemic Monotherapies Including Lebrikizumab for Moderate-to-Severe Atopic Dermatitis: a Network Meta-Analysis
Authors: Silverberg Jonathan , Bieber Thomas , Paller Amy , Beck Lisa , Kamata Masahiro , Puig Luis , Wiseman Marni , Ezzedine Khaled , Foley Peter , Johansson Erin , Dossenbach Martin , Akmaz Bülent , Casillas Marta , Karlsson Andrei , Chovatiya Raj 
Published: January 2024

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting 2–7% of adults globally, with 30% experiencing moderate-to-severe disease. Although several treatments for moderate-to-severe AD are available, the efficacy of many treatments has not been compared in head-to-head trials. Using a network meta-analysis (NMA), we evaluated the relative efficacy between lebrikizumab, an emerging biologic, and approved targeted systemic treatments for AD.
Methods: Double-blind, randomized, placebo-controlled clinical trials (systemic monotherapy-only) for moderate-to-severe AD in adults (≥18 years) and adolescents (≥12 years to ≤18 years) published before April 2023 were identified in a systematic literature review. Data were extracted for short-term (12–16 weeks) efficacy outcomes (Investigator’s Global Assessment [IGA] 0/1 with ≥2-point improvement from baseline and the Eczema Area and Severity Index [EASI]) and patient-reported outcomes (Peak Pruritus Numeric Rating Scale [PP-NRS] with ≥4-point improvement from baseline). Bayesian NMAs were performed using random-effects models, with baseline-risk adjustment. Key estimates from the NMAs included pairwise differences between all treatments and absolute response rates for each treatment.
Results: Twenty-three clinical trials were included. For % achieving IGA 0/1, at 12–16 weeks, the estimated response rates (posterior median and 95% credible interval) for each of the treatments were: upadacitinib 30 mg 56% (46–65%), upadacitinib 15 mg 42% (32–50%), abrocitinib 200 mg 38% (31–45%), lebrikizumab 250 mg 32% (25–40%), dupilumab 300 mg 32% (24–39%), abrocitinib 100 mg 26% (20–32%), tralokinumab 300 mg 18% (13–22%), baricitinib 4 mg 17% (10–25%), baricitinib 2 mg 16% (10–22%), and placebo 6% (5–8%). Similar trends were observed for the EASI and PP-NRS responses at 12–16 weeks.
Conclusion: This 16-week NMA analysis shows that lebrikizumab had a similar response rate to dupilumab, the most widely used targeted systemic therapy for AD, and may represent a valuable treatment alternative for moderate-to-severe AD.