bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired interleukin-8- and GROα-induced phosphorylation of extracellular signal-regulated kinase result in decreased migration of neutrophils from patients with myelodysplasia
Authors: Fuhler Gwenny M , Knol Gerlinde J , Drayer A Lyndsay , Vellenga Edo 
Published: November 2004

Abstract
Patients with myelodysplasia suffer from recurrent bacterial infections as a result of differentiation defects of the myeloid lineage and a disturbed functioning of neutrophilic granulocytes. Important physiological activators of neutrophils are the cytokines interleukin-8/CXC chemokine ligand 8 (IL-8/CXCL8), which activates CXC chemokine receptor 1 and 2 (CXCR1 and CXCR2), and growth-related oncogene (GROα)/CXCL1, which stimulates only CXCR2. In this study, we show that migration toward IL-8/GROα gradients is decreased in myelodysplastic syndrome (MDS) neutrophils compared with healthy donors. We investigated the signal transduction pathways involved in IL-8/GROα-induced migration and showed that specific inhibitors for extracellular signal-regulated kinase (ERK)1/2 and phosphatidylinositol-3 kinase (PI-3K) abrogated neutrophil migration toward IL-8/GROα. In accordance with these results, we subsequently showed that IL-8/GROα-stimulated activation of ERK1/2 was substantially diminished in MDS neutrophils. Activation of the PI-3K downstream target protein kinase B/Akt was disturbed in MDS neutrophils when cells were activated with IL-8 but normal upon GROα stimulation. IL-8 stimulation resulted in higher migratory behavior and ERK1/2 activation than GROα stimulation, suggesting a greater importance of CXCR1. We then investigated IL-8-induced activation of the small GTPase Rac implicated in ERK1/2-dependent migration and found that it was less efficient in neutrophils from MDS patients compared with healthy donors. In contrast, IL-8 triggered a normal activation of the GTPases Ras and Ral, indicating that the observed defects were not a result of a general disturbance in CXCR1/2 signaling. In conclusion, our results demonstrate a disturbed CXCR1- and CXCR2-induced neutrophil chemotaxis in MDS patients, which might be the consequence of decreased Rac-ERK1/2 and PI-3K activation within these cells.
Pharmacologic Prevention or Delay of Type 2 Diabetes Mellitus
Authors: Anderson Douglas C 
Published: November 2004

OBJECTIVE: To evaluate the current data on pharmacologic interventions intended to prevent or delay the onset of type 2 diabetes mellitus. DATA SOURCES: Searches of MEDLINE (1966–July 2002) and an extensive manual review of journals were performed using the key search terms diabetes mellitus, metformin, acarbose, troglitazone, orlistat, nateglinide, risk reduction, and prevention. STUDY SELECTION AND DATA EXTRACTION: All articles identified from the data sources were evaluated, and all information deemed relevant was included for this review. Randomized controlled trials and meta-analyses were included if the primary outcome measure was prevention of diabetes and/or change in the rate of progression to diabetes. DATA SYNTHESIS: Type 2 diabetes mellitus is a growing epidemic. Major risk factors include obesity, impaired glucose tolerance, and impaired fasting glucose. Complications of diabetes result in significant morbidity and mortality and are a substantial public health issue. Four randomized, blinded, controlled trials have assessed the efficacy of different medications, including metformin, troglitazone, acarbose, and orlistat, at decreasing the risk of progression to diabetes in patients at risk for developing diabetes. All of these agents decreased the risk of progression to diabetes. CONCLUSIONS: Metformin, troglitazone, acarbose, and orlistat have been shown to decrease the risk of progression to diabetes in patients at risk for developing diabetes. Other questions that address issues such as identifying target populations, cost-effectiveness, and screening strategies must be answered to more fully define the place of pharmacologic therapy to prevent or delay diabetes.
Incretin Mimetics as Emerging Treatments for Type 2 Diabetes
Authors: Joy Scott V , Rodgers Philip T , Scates Ann C 
Published: November 2004

OBJECTIVE: To review the physiology, pharmacology, and clinical efficacy of glucagon-like peptide (GLP-1) and the incretin mimetics exenatide and liraglutide in clinical studies. DATA SOURCES: Primary literature obtained via MEDLINE (1966–April 2004) and International Pharmaceutical Abstracts (1970–April 2004) searches; abstracts obtained from meeting sources and manufacturers. STUDY SELECTION AND DATA EXTRACTION: All English-language studies and abstracts evaluating GLP-1, exenatide, and liraglutide in the treatment of patients with type 2 diabetes were reviewed. Data from animal studies were also included if human data were not available. Primary and review articles related to the physiology, development, and evaluation of GLP-1s were reviewed. DATA SYNTHESIS: GLP-1, exenatide (exendin-4, AC2993), and liraglutide (NN2211) are incretin mimetics that have been shown in human studies to be an effective treatment to improve glycemic control in patients with type 2 diabetes. Mechanisms by which these compounds improve glycemic control include enhancing glucose-dependent pancreatic secretion of insulin in response to nutrient intake, inhibiting glucagon secretion, delaying gastric emptying, and promoting early satiety. GLP-1 has been shown to promote pancreatic progenitor cell differentiation and improve β-cell function and lifespan. Reported adverse effects of exenatide and liraglutide include nausea, vomiting, and transient headache, as well as increased risk of hypoglycemia when used with sulfonylureas. CONCLUSIONS: Clinical studies show that GLP-1, exenatide, and liraglutide improve glycemic control for patients with type 2 diabetes through unique mechanisms not available with current pharmaceutical products. Ongoing Phase III studies will help to further position these compounds as treatment options for patients with type 2 diabetes.
Acute Rhabdomyolysis Associated with Ofloxacin/Levofloxacin Therapy
Authors: Hsiao Shu-Hwa , Chang Chia-Ming , Tsao Chao-Jung , Lee Yu-Yun J , Hsu May-Ying , Wu Ta-Jen 
Published: November 2004

OBJECTIVE: To report a case of ofloxacin/levofloxacin-induced rhabdomyolysis and to compare other reported cases from the literature. CASE SUMMARY: A 19-year-old male patient developed ofloxacin/levofloxacin-induced rhabdomyolysis during admission for periorbital cellulitis. Symptoms of myalgia, weakness, and swelling of the arms developed after 3 days of treatment with ofloxacin 800 mg/day. Laboratory analysis confirmed the presence of urine myoglobin (381.2 μg/L) and a marked increase in serum myoglobin (590.8 μg/L), along with marked elevations in serum creatine kinase (up to 16 546 IU/L). DISCUSSION: In addition to ruling out other possible etiologic factors one by one, we assessed the probability of ofloxacin/levofloxacin-induced rhabdomyolysis by observing the close time relationship between drug administration and the development of symptoms/signs, as well as the close time relationship between drug withdrawal and the disappearance of symptoms/signs. An objective causality assessment by use of the Naranjo probability scale revealed that the adverse drug reaction was probable. CONCLUSIONS: Although ofloxacin/levofloxacin-induced rhabdomyolysis appears to be rare, patients with muscle pain, swelling, or weakness during therapy should be closely monitored for this adverse effect.
Entwurf von Multiraten-Abtastregelkreisen mit Linearer Programmierung (Design of Multirate Digital Control Systems with Linear Programming)
Authors: Hofer Anton , Horn Martin 
Published: November 2004

Abstract
In diesem Beitrag wird ein Verfahren zum Entwurf linearer Multiraten-Abtastregelkreise vorgestellt, wobei als Grundlage die Supremumsnorm für Signale und daraus abgeleitet die l
1-Norm für Übertragungssysteme zur Formulierung des Syntheseproblems verwendet werden. Es ist charakteristisch für die Synthesemethode, dass sie bei der praktischen Umsetzung die mehrfache Lösung kleiner Linearer Programme erfordert. An einem Beispiel wird demonstriert, dass der Multiraten-Ansatz eine wirksame Maßnahme zur Behebung des bekannten Problems der hohen Reglerordnung beim l
1-Entwurf sein kann.
Steuersysteme im Flugzeug – Fly-By-Wire (Flight Control Systems – Fly-By-Wire)
Authors: Reichel Reinhard 
Published: November 2004

Abstract
Der Einsatz komplexer Automatisierungsfunktionen erfordert computergesteuerte Plattformen. Werden solche Plattformen wie bei der Flugsteuerung in Bereichen eingesetzt, in denen das Leben von Personen unmittelbar vom sicheren Funktionieren der Plattform abhängt, muss diese ausfallsicher ausgelegt sein. Dieser Beitrag erörtert die zentralen Sicherheitsanforderungen an sicherheitskritische Fly-By-Wire-Plattformen, zeigt einen Weg der Verknüpfung von Sicherheitsanalyse und Systementwurf auf und stellt ergänzend zwei heute im Einsatz stehende und eine neue in einem Technologieprogramm erprobte Fly-By-Wire-Plattform dar.
anthropologizing America
Authors: LöFGREN ORVAR 
Published: November 2004

All That Is Native and Fine: The Politics of Culture in an American Region. DAVID E. WHISNANT. Chapel Hill:Klnshlp and Pllgrlmage: Rituals of Reunion in American Protestant Culture. GWEN KENNEDY NEVILLE.Wheeling and Dealing: An Ethnography of an Upper‐Level Drug Deallng and Smuggling Community. PATRICIA A. ADLER.Advertising the American Dream: Making Way for Modernity 7920‐1940. ROLAND MARCHAND.
do the natives prefer Durkheim?
Authors: GREENHOUSE CAROL J. 
Published: November 2004

The Moral Order of a Suburb. M. P. BAUMGARTNER.Pilgrims of Paradox: Calvinism and Experience among the Primitive Baptists of the Blue Ridge. JAMES L. PEACOCK and RUEL W. TYSON, JR.The Southern Baptists: A Subculture in Transition. ELLEN M. ROSENBERG.
Discursive monotheisms
Authors: BOWEN JOHN R. 
Published: November 2004

Religious Orthodoxy and Popular Faith in European Society. ELLEN BADONE, ed. Princeton, NJ: Princeton University Press, 1990. 230 pp., maps, photographs, tables, notes, references, index.Beyond the Text: A Holistic Approach to Liturgy. LAWRENCE A. HOFFMAN. Jewish Literature and Culture. ALVIN ROSENFELD, series ed. Bloomington and Indianapolis: Indiana University Press, 1987. vii + 213 pp., figure, appendix, notes, index.Debating Muslims: Cultural Dialogues in Postmodernity and Tradition. MICHAEL M. J. FISCHER and MEHDI ABEDI. New Directions in Anthropological Writing. GEORGE E. MARCUS and JAMES CLIFFORD, gen. eds. Madison and London: University of Wisconsin Press, 1990. xxxvi + 564 pp., illustrations, appendixes, notes, glossary, bibliography, index.
midwives, godmothers, and witches: female body and identity in the Italian south
Authors: DURANTI ALESSANDRO 
Published: November 2004

Madre madrina: Rituale, parentela e identità in un paese del Sannio (San Marco dei Cavoti). BERNARDINO PALUMBOItinerari delle emozioni: Corpo e identità femminile nel Sannio Campano. MARIELLA PANDOLFI
Fantasizing the Feminine In Indonesia./"Male" and "Female" In Developing Southeast Asia
Authors: Kipp Rita Smith 
Published: November 2004

Fantasizing the Feminine In Indonesia. Laurie J. Sears. ed. Durham, NC: Duke University Press, 1996. xvi. 349 pp., illustrations, notes, selected bibliography, contributors, index."Male" and "Female" In Developing Southeast Asia. Wazir Jahan Karim. ed. Oxford: Berg Publishers, 1995. xiv. 267 pp., notes, references, contributors, index.
Carnival and Culture: Sex, Symbol, and Status in Spain; Carnival Song and Society: Gossip, Sexuality, and Creativity in Andalusia
Authors: Norget Kristin 
Published: November 2004

Carnival and Culture: Sex, Symbol, and Status in Spain. David D. Cilmore. New Haven: Yale University Press, 1998. ix. 244 pp., photo‐graphs, notes, bibliography, index.Carnival Song and Society: Gossip, Sexuality, and Creativity in Andalusia. Jerome R. Mintz. Oxford: Berg Publishers, 1997. ix. 267 pp., maps, index,
Money and Modernity: State and Local Currencies in Melanesia; Border Fetishisms: Material Objects in Unstable Spaces
Authors: Graeber David 
Published: November 2004

Money and Modernity: State and Local Currencies in Melanesia. David Akin and Joel Robbins. Pittsburgh: University of Pittsburgh Press, 1999. viii. 284 pp., notes, bibliography, index.Border Fetishisms: Material Objects in Unstable Spaces. Patricia Spyer. London: Routledge Press, 1998. vii. 262 pp., illustrations, photographs, index.
Facts on the Ground: Archaeological Practice and Territorial Self‐Fashioning in Israeli Society.; Whose Pharaohs? Archaeology, Museums, and Egyptian National Identity from Napoleon to World War I.
Authors: Smith Kimbra L. 
Published: November 2004

Facts on the Ground: Archaeological Practice and Territorial Self‐Fashioning in Israeli Society. Nadia Abu El‐Haj .Chicago: University of Chicago Press, 2001. vii. 352 pp., illustrations, notes, bibliography, index.Whose Pharaohs? Archaeology, Museums, and Egyptian National Identity from Napoleon to World War I. Donald Malcolm Reid .Reid. Berkeley. University of California Press, 2002. ix. 409 pp., illustrations, appendix, notes, bibliography, index.
Making Their Way: Four Books on Youth, Culture, and Identity
Authors: Mickelson Roslyn Arun 
Published: November 2004

Peer Power: Preadolescent Culture and Identity. Patricia A. Adler and Peter Adler. New Brunswick, NJ: Rutgers University Press, 1998. 257 pp.Angels' Town: Chero Ways, Gang Life, and Rhetorics of the Everyday. Ralph Cintron. Boston: Beacon Press, 1997. 264 pp.Everyday Courage: The Lives and Stories of Urban Teenagers. Niobe Way. New York: New York University Press, 1998. 310 pp.At Home in the Street: Street Children of Northeast Brazil. Tobias Hecht. New York: Cambridge University Press, 1998. 267 pp.
Ritualizing the Play of Politics
Authors: Martin Randy 
Published: November 2004

Richard Schechner The Future of Ritual: Writings on Culture and Performance. London: Routledge, 1993. + 283 pp.Mady Schutzman and Jan Cohen‐Cruz. eds. Playing Boal: Theatre, Therapy, Activism. London: Routledge, 1994. + 245 pp.
The Ethnography of the Senses
Authors: Polotnicov Leonard 
Published: November 2004

Paul Stoller. The Taste of Ethnographic Things: The Senses in Anthropology. Philadelphia: University of Pennsylvania Press, 1989. xv. 182 pp.Paul Stoller. Fusion of the Worlds: An Ethnography of Possession among the Songhay of Niger. Chicago: The University of Chicago Press, 1989. xxii. 244 pp.
The Anthropology of Art: Varmints, Videos, Bowerbirds, and More
Authors: Field Karen L. 
Published: November 2004

George E. Marcus and Fred R. Myers. eds. The Traffic in Culture: Refiguring Art and Anthropology. Berkeley: University of California Press, 1995. 380 pp.Ellen Dissanayake Homo Aestheticus: Where Art Comes From and Why. Seattle: University of Washington Press, 1995. xx. 297 pp.
Also Chosen: Jews in the Imagination and Life of a Black Sanctified Church
Authors: Crumbley Deidre Helen 
Published: November 2004

"The Church," an unaffiliated sanctified community, was founded in Philadelphia between World Wars I and II by participants in the Great Migration of Blacks from the rural South. Generally lacking in specialized labor skills, they arrived in Philadelphia at a time when industry was shifting to the suburbs. Founding members who referred to each other as "saints" settled in the inner city, and most worked for, or were clients of, Jews. Yet, in spite of the middleman role of Jews in their community, the saints shared positive sentiments toward Jews, invoking them as role models of success.This article investigates the subversion of potential anti‐Semitism by assessing the interplay of sociohistorical conditions of urban migration with the belief in chosenness held by the saints. For the founding saints, salvation came through Jesus Christ; but it also came by the law, which they interpreted to include selected Levitical laws. Thus, they believed that they were effectively "grafted" into a contractual relationship with God, similar to the covenant God had with ancient Israel. Like the Jews, the saints saw themselves as chosen, and through compliance with divine law they would be blessed in every aspect of life.Being chosen was also associated with holiness effected by separation from "The World." This socially distanced the saints—already physically distanced from their southern communities—from the larger Black community that could have provided Black role models. Jews, who were visibly successful, filled this gap. Feeling just as chosen as Jews, the saints harbored less anti‐Semitic resentment. As both groups shared the same love and bounty of the law, the boundaries between the saints and "Jews as other" were blurred.
Woman/Women in “the Discourse of Man”: Edie Turner and Victor Turner's Language of the Feminine
Authors: Babcock Barbara A. 
Published: November 2004

Although much has been said about the dialectic of structure and antistructure, of system and process, of reason and passion, and of poetry and science in Victor Turner's anthropology, it is rarely noted that such oppositions are profoundly gendered.Like Nietzsche's philosophy, Turner's anthropology may be described as “gynesis”—a putting of Woman into discourse. That which disrupts reason and structure is feminine by definition, and the figure of Woman has been deployed to deconstruct “the discourse of man” for thousands of Western centuries—in Turner's words, “communitas wears a skirt.” And liminality and antistructure as well as communitas are repeatedly described in conceits of conception such as “seedbeds of cultural creativity,” fons et origo, “fructile chaos,”“regenerative abyss,” and “storehouse of possibilities.” If Woman is figuratively significant in Turner's texts, women literally inhabit the interstices of the anthropology that he lived and wrote. Of these, the undisciplined/disciplined and devoted Edie is, of course, the most important. But in addition to her profound and unquestionable presence, there are the echoes of other thinking women—Victor's actress mother, Dorothy Emmett, Monica Wilson, Mary Douglas, Sally Falk Moore, Barbara Myerhoff, Natalie Zemon Davis, and me. What are the meanings of this matrilineage, the relationship of Woman and women, and the reasons of Turner's unreason?
Current Approaches to African Linguistics, Vol. 5 and Current Approaches to African Linguistics, Vol. 6
Authors: Moshi Lioba 
Published: November 2004

Current Approaches to African Linguistics (Vol. 5) Paul Newman Robert D. Botne eds. Publications in African Languages and Linguistics, 8. Dordrecht/ Providence: Foris Publications, 1989. 266 pp. $60.00 (paper)Current Approaches to African Linguistics (Vol. 6) lsabelle Haik Laurice Tuller eds. Publications in African Languages and Linguistics, 9. Dordrecht/ Providence: Foris Publications, 1989. 336 pp. $40.00 (paper)
Language, Culture and Communication in Contemporary Europe.; Language and the State: Revitalization and Revival in Israel and E'ire.; Language Policy and Social Reproduction: Ireland 1893–1993.
Authors: Quinn Eileen Moore 
Published: November 2004

Language, Culture and Communication in Contemporary Europe. Charlotte Hoffmann. ed. Bristol, PA: Multilingual Matters, Ltd., 1996. 165 pp.Language and the State: Revitalization and Revival in Israel and E'ire. Sue Wright. ed. Bristol, PA: Multilingual Matters, Ltd., 1996. 75 pp.Language Policy and Social Reproduction: Ireland 1893–1993. Pddráig O'Riagáin. Oxford: Clarendon Press, 1997. 297 pp.
AIDS and Anthropologists: Ten Years Later
Authors: Farmer Paul 
Published: November 2004

Global AIDS Policy. Douglas A. Feldman. ed. Westport, CT: Bergin and Garvey, 1994 (cloth and paper),. + 250 pp.AIDS and STDs in Africa: Bridging the Gap between Traditional Healing and Modern Medicine. Edward C. Green. Boulder, CO: Westview Press, 1994. xii. 276 pp.Hidden in the Blood:. Personal Investigation of AIDS in the Yucatan. Carter Wilson. New York: Columbia University Press, 1995 (cloth and paper), xx. 168 pp.Plague Doctors: Responding to the AIDS Epidemic in France and America. Jamie L. Feldman. Westport, CT: Bergin and Garvey, 1995 (cloth), xii. 273 pp.Young People at Risk: Fighting AIDS in Northern Tanzania. Knut‐Inge Klepp. Paul M. Biswalo. and Aud Talle. eds.Oslo: Scandinavian University Press, 1995 (cloth), xxviii. 243 pp.AIDS is. Kind of Kahungo That Kills. Hanne Overgaard Mogensen. Oslo: Scandinavian University Press, 1995 (cloth and paper), ix. 135 pp.Les Sciences Sociales Face au Sida: Cas Africains autour de l'Exemple Ivoirien. Jean‐Pierre Dozon and Laurent Vidal. eds. Paris: Orstom, 1995 (paper). 300 pp.Sida et Anthropologie: Bilan et Perspectives. Jean Benoist and Alice Desclaux. eds. Paris: Karthala, 1995 (paper). 412 pp.
The Anthropology of Infectious Disease: International Health Perspectives and The Kiss of Death: Chagas' Disease in the Americas
Authors: Manderson Lenore 
Published: November 2004

The Anthropology of Infectious Disease: International Health Perspectives. Marcia C. Inhorn and Peter J. Brown. eds. Amsterdam: Gordon and Breach, Publishers, 1997. xv+ 495 pp.The Kiss of Death: Chagas' Disease in the Americas. Joseph William Bastien. Salt Lake City: The University of Utah Press, 1998. xxiv +301 pp.
Indigenous Legal Issues; In the Wake of Terra Nullius
Authors: De Nike Howard J. 
Published: November 2004

Indigenous Legal Issues by Heather McRae. Garth Nettheim and Laura Beacroft, Commentary and Materials. Sydney: The Law Book Company, 1997. 540 pages.In the Wake of Terra Nullius by Colin Perrin. ed. Volume 4, Law · Text · Culture. St Leonards, New South Wales: Prospect Media Pty Ltd, 1998. 351 pages.
Clericuzio type poikiloderma with neutropenia is distinct from Rothmund–Thomson syndrome
Authors: Van Hove Johan L.K. , Jaeken Jaak , Proesmans Marijke , Boeck Kris De , Minner Kristin , Matthijs Gert , Verbeken Eric , Demunter Anouk , Boogaerts Marc 
Published: November 2004

AbstractTwo siblings from a consanguineous family presented with a poikiloderma of limbs and face, plantar keratoderma, and toenail pachyonychia. Neutropenia and neutrophil dysfunction with impairment of the respiratory burst and bacterial killing resulted in frequent respiratory tract infections. A bronchocentric granulomatous pneumonia was a fatal complication. The clinical presentation is consistent with Clericuzio type poikiloderma with neutropenia. Literature review identified several additional probable patients. Genetic linkage analysis excluded the locus of the RECQL4 gene, mutations in which have been described in some patients with the Rothmund–Thomson poikiloderma syndrome. This report confirms the clinical and genetic identity of the Clericuzio type of poikiloderma with neutropenia syndrome. © 2004 Wiley‐Liss, Inc.