bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of employee goal orientation on change-supportive behavior: a moderated mediation approach
Authors: Liu Mengli , Bai Minglei , Liu Bing , Li Yuhan 
Published: October 2023

PurposeBased on goal orientation theory, this study aims to examine how and when employees' performance goal orientations (PGOs) affect their change-supportive behavior in entrepreneurial firms undergoing change.Design/methodology/approachA two-wave time-lagged research design was applied to collect data from companies undergoing change in China.FindingsThe results showed that employees' performance-proving goal orientation (PPGO) was positively related to change-supportive behavior, and employees' performance-avoiding goal orientation (PAGO) was negatively related to change-supportive behavior. Openness to change played a mediating role in these mechanisms, and employees' learning goal orientation (LGO) played a moderating role.Originality/valueBy solving the mechanism of the relationship between PGOs and change-supportive behavior that has not been explored before, this study answers the question of how and when different PGOs affect support behavior.
Exploring teacher collaboration: what's inside the Malaysian PLC black box?
Authors: Mohd Zabidi Zuliana , Abdullah Zuraidah , Sumintono Bambang 
Published: October 2023

PurposeThe purpose of this study is to explore mathematics teachers' collaboration within their professional learning communities (PLCs), and to gain insight into how the teachers developed their collective efficacy through it to focus on improving student learning.Design/methodology/approachUsing a qualitative approach, data were collected from three high-performing secondary schools, mainly through semi-structured in-depth interviews with the Heads of Mathematics Unit. For explication and triangulation purposes, focus group interviews with the mathematics teachers and students and document analysis were also conducted.FindingsThe findings indicate that PLCs were the vessel through which a culture of disciplined teacher collaboration was fostered. More importantly, this culture encouraged teachers to participate in reflective dialogues that became a driver for their learning, and eventually led to their changed professional practice for improved student learning. The collaborative setting within the PLCs allowed teachers to pool their resources, knowledge and individual expertise to identify their student learning focus, and administer and measure their student intervention strategies. This collaborative professional learning reduced professional isolation, and as a result, improved teachers' collective pursuit of professional growth to impact student outcomes.Research limitations/implicationsThe aim of this qualitative study was to provide a detailed description of the teachers' collaboration within their PLCs based on the researchers' interpretation of how the participants make sense of their PLC practices and experiences. Hence, findings are indicative, and not definitive. In addition, the Heads of the Mathematics Unit, and the mathematics teacher participants in this study illustrated salient aspects of subject subcultures, where their beliefs, norms and practices were non-generic, or specific only to their subject context. Therefore, the implications to practice were built from commonalities shared only among the mathematics units.Originality/valueThis is a study in a Malaysian context that provides empirical evidences that are concerned primarily with the process of teachers developing their collective efficacy through disciplined collaboration within their PLCs.
Insight into advances for the biosynthetic progress of fermented echinocandins of antifungals
Authors: Jiang Kaili , Luo Pan , Wang Xinxin , Lu Ling 
Published: October 2023

AbstractInvasive fungal infections have increased remarkably, which have become unprecedented concern to human health. However, the effectiveness of current antifungal drugs is limited due to drug resistance and toxic side‐effects. It is urgently required to establish the effective biosynthetic strategy for developing novel and safe antifungal molecules economically. Echinocandins become a promising option as a mainstay family of antifungals, due to specifically targeting the fungal specific cell wall. To date, three kinds of echinocandins for caspofungin, anidulafungin, and micafungin, which derived from pneumocandin B0, echinocandin B, and FR901379, are commercially available in clinic and have shown potential in managing invasive fungal infections in a cost‐effective manner. However, current echinocandins‐derived precursors all are produced by environmental fungal isolates with long fermentation cycle and low yields, which challenge the production efficacy of these precursors in industry. Therefore, understanding their biosynthetic machinery is of great importance for improving antifungal titres and creating new echinocandins‐derived products. With the development of genome‐wide sequencing and establishment of gene‐editing technology, there are a growing number of reports on echinocandins‐derived products and their biosynthetic gene clusters. This review briefly summarizes the discovery and development history of echinocandins, compares their structural characteristics and biosynthetic processes, and sums up existed strategies for improving their production. Moreover, the genomic analysis of related biosynthetic gene clusters of echinocandins is discussed, highlighting the similarities and differences among the clusters. Last, the biosynthetic processes of echinocandins are compared, focusing on the activation and attachment of side‐chains and the formation of the hexapeptide core. This review aims to provide insights into the development and production of new echinocandin drugs by modifying the structure of echinocandin‐derived precursors and/or optimizing the fermentation processes; and achieve a new microbial chassis for efficient production of echinocandins in heterologous hosts.
Adolescent exposure to sucrose increases cocaine‐mediated behaviours in adulthood via Smad3
Authors: Gancarz Amy M. , Parmar Raveena , Shwani Treefa , Cobb Moriah M. , Crawford Michelle N. , Watson Jacob R. , Evans Lisa , Kausch Michael A. , Werner Craig T. , Dietz David M. 
Published: October 2023

AbstractAdolescence, a critical period of developmental period, is marked by neurobiological changes influenced by environmental factors. Here, we show how exposure to sucrose, which is ubiquitously available in modern diets, results in changes in behavioural response to cocaine as an adult. Rats were given daily access to either 10% sucrose or water during the adolescent period (PND28–42). Following this period, rats are left undisturbed until they reach adulthood. In adulthood, rats were tested for (i) acquisition of a low dose of cocaine, (ii) progressive ratio (PR) test, and (iii) resistance to punished cocaine taking. Sucrose exposure resulted in significant alterations in all behavioural measures. To determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor Smad3 in the nucleus accumbens (NAc) when compared with water‐exposed controls. Transiently blocking the active form of this transcription factor (HSV‐dnSmad3) during adolescence mitigated the enhanced cocaine vulnerability‐like behaviours observed in adulthood. These findings suggest that prior exposure to sucrose during adolescence can heighten the reinforcing effects of cocaine. Furthermore, they identify the TGF‐beta pathway and Smad3 as playing a key role in mediating enduring and long‐lasting adaptations that contribute to sucrose‐induced susceptibility to cocaine. Taken together, these results have important implications for development and suggest that adolescent sucrose exposure may persistently enhance the susceptibility to substance abuse.
The changes of intrinsic connectivity contrast in young smokers
Authors: Zhou Yang , Xue Ting , Cheng Yongxin , Wang Juan , Dong Fang , Jia Shaodi , Zhang Fan , Wang Xiaoqing , Lv Xiaoqi , Wang Hongde , Yuan Kai , Yu Dahua 
Published: October 2023

AbstractPrevious studies demonstrated that reward circuit plays an important role in smoking. The differences of functional and structural connectivity were found among several brain regions such as thalamus and frontal lobe. However, few studies focused on functional connectivity (FC) in whole‐brain voxel level of young smokers. In this study, intrinsic connectivity contrast (ICC) was used to perform voxel‐based whole‐brain analyses in 55 young smokers and 55 matched non‐smokers to identify brain regions with significant group differences. ICC results showed that the connectivity of young smokers in medial frontal cortex (MedFC), supramarginal gyrus anterior division left (L_aSMG), central opercular cortex left (L_CO) and middle frontal gyrus left (L_MidFG) showed a significantly lower trend compared with the non‐smokers. The seed‐based FC analysis about MedFC indicated that young smokers showed reduced connectivity between the MedFC and left hippocampus, left amygdala compared to non‐smokers. Correlation analysis showed that the ICC of MedFC in young smokers was significantly negatively correlated with Fagerstrom test for nicotine dependence (FTND) and Questionnaire on Smoking Urges (QSU). The FC between the MedFC and left hippocampus, left amygdala was significantly negatively correlated with Pack_years. The mediation analysis indicated that ICC of MedFC completely mediated FTND and QSU of young smokers. The results suggest that nicotine accumulation may affect the communication of the frontal lobe with the whole brain to some extent, leading to changes in smoking cravings. The above research also provides in‐depth insights into the mechanism of adolescent smoking addiction and related intervention treatment.
Medium‐term evaluation of the bond strength and dentin penetration of self‐adhesive resin cements to root dentin
Authors: Gelio MB , Zaniboni JF , Monteiro JCC , Besegato JF , Pereira JR , Buchaim RL , Kuga MC 
Published: October 2023

AbstractBackgroundMedium‐term evaluate the bond strength and tag formation in root dentin using self‐adhesive cements Maxcem Elite (MCE), Relyx U200 (RU2), SeT PP (SPP) and Megalink (MGL) compared to conventional cement Relyx ARC (ARC) for glass fibre post cementation.Materials and methodsOne hundred bovine incisors roots were endodontically treated and divided into 5 groups (n = 20) according to the cementation system: MCE, RU2, SPP, MGL and ARC. All cementation systems were evaluated at 24 h (1) and 12 months (2) after post cementation. Specimens from the cervical, middle and apical thirds of the root were submitted to push‐out bond strength test and confocal laser microscopy to verify the dentin penetration. The adhesive failure mode was classified as adhesive, cohesive and mixed. Data were analysed by one‐way ANOVA and Tukey tests (α = 5%).ResultsARC‐1 and ARC‐12 showed the highest bond strength (P < 0.05). ARC showed the greatest tag extension, regardless of the third (P < 0.05). The most frequent failure mode in the 24‐h analysis was cohesive, regardless of the cement used. For the 12‐month analysis, mixed failure was the most frequent.ConclusionConventional cement (ARC) showed the highest bond strength and tag extension, regardless of the evaluation period. In all cementation systems, the bond strength decreased after 12 months. © 2023 Australian Dental Association.
Association between VDR genetic polymorphisms and risk of gestational diabetes mellitus in the Chinese population
Authors: Ma Yantuanjin , Zhang Yuhang , He Qiuyue , Xu Tong , Huang Wei , Deng Xingli , Qian Yuan 
Published: October 2023

AbstractBackground and aimsAbnormal metabolism of vitamin D was the primary mechanism in many pregnancy diseases. Our study was the first to examine the hypothesis that VDR gene polymorphisms contribute to the risk of gestational diabetes mellitus (GDM) in the Chinese population at high altitudes.Materials and methodsOne hundred and eighteen women with GDM and 104 women with normal glucose tolerance (NGT) were included in this study using a case‐control design. Four single nucleotide polymorphisms (g.47879112G > A, g.47846052C > T, g.47844974A > G, and g.47845054C > A) of mother and fetus were genotyped.ResultsMaternal and fetal frequency of the A allele of g.47879112G > A was significantly increased in women with GDM than in those with NGT (p < .05). A correlation between the AA homozygous genotype of g.47879112G > A and GDM was noted. Compared with non‐carriers, A allele carriers showed higher fasting plasma insulin and two‐hour post‐challenge plasma glucose (2h‐PPG), and lower levels of vitamin D. Furthermore, both maternal and fetal 4‐marker haplotype ACCG were found to be significantly associated with GDM (p < .05).ConclusionsAssociation and haplotype analysis indicated that the A allele of g.47879112G > A could be a risk factor for GDM development in the Chinese population at high altitudes. Additionally, the VDR gene polymorphism of the fetus and mother may have a synergistic effect. The VDR polymorphism is associated with an increased risk of GDM and may be useful for predicting the development of the disease.
Paternal pre‐conceptional smoking and semen quality in the adult son
Authors: Hærvig Katia Keglberg , Petersen Kajsa Ugelvig , Dornfeldt Mette Møller , Bonde Jens Peter , Hougaard Karin Sørig , Ramlau‐Hansen Cecilia Høst , Toft Gunnar , Lindh Christian , Giwercman Aleksander , Tøttenborg Sandra Søgaard 
Published: October 2023

AbstractBackgroundGrowing evidence suggests intergenerational effects of paternal pre‐conceptional smoking through the germ line, but its specific impact on offspring semen quality remains uncertain because of challenges in isolating paternal exposure from maternal passive smoking or underreporting.MethodsWe reran previous analyses estimating differences in semen parameters and testicular size according to paternal smoking in 867 young adult men, adding first‐trimester maternal plasma cotinine to the original adjustment for maternal self‐reported smoking. We also estimated differences in sperm DNA fragmentation. Paternal smoking was reported by the pregnant women around gestational week 16. Analyses were additionally adjusted for household occupational status, parental ages at birth, maternal pre‐pregnancy body mass index and alcohol consumption, and abstinence time, and accounted for spillage, minutes from ejaculation to analysis, and son's own smoking.ResultsWe found no association between paternal preconceptional smoking and any of the semen parameters or testicular size. Adjustment for son's own smoking did not change results.DiscussionWhile maternal plasma cotinine offers an objective measure of tobacco exposure and allows for a more thorough adjustment of maternal smoking, the high correlation between paternal pre‐conceptional smoking and maternal cotinine exposure may, have resulted in overadjustment removing some paternal effect. Inability to distinguish between paternal never smokers and former smokers, may have led to misclassification of paternal pre‐conceptional smoking and underestimation of associations.ConclusionWe found no support for an independent association between paternal pre‐conceptional smoking and semen quality in young adult sons, but studies with more detailed paternal smoking history are needed before firm conclusions can be drawn.
Laparoscopic common bile duct exploration: what factors determine success?
Authors: Sirimanna Pramudith , Suh Hyerim , Falk Gregory L. 
Published: October 2023

AbstractBackgroundsLaparoscopic common bile duct exploration (LCBDE) has been shown to be effective in managing choledocholithiasis whilst avoiding ERCP‐related complications. However, patient and technical factors effects outcome. This study aimed to explore the matters effecting the failure of LCBDE.MethodsAll patients who underwent a laparoscopic cholecystectomy (LC) between 2007 and 2021 were identified using a prospective database. Data were collected for patients who underwent LCBDE including demographics, pre‐operative investigations, intra‐operative findings, technique of bile duct clearance and clearance rates, and post‐operative outcomes. Predictors of failed LCBDE were identified.ResultsLaparoscopic cholecystectomy was performed in 3648 patients. Of these, 374 underwent LCBDE for suspected choledocholithiasis. Choledochoscopy was most frequently used (58.8%) with a success rate of 84.1%. Small cystic duct diameter (4.7 vs. 3.4 mm, P = 0.002), stone size >6 mm (P = 0.02), stone: cystic duct ratio >1 (P = 0.04), and >3 stones was associated with failed LCBDE by univariate analysis. Small cystic duct diameter (OR: 0.45, 95% CI: 0.26–0.77, P = 0.004) and stone size >6 mm (OR: 0.23, 95% CI: 0.06–0.92), P = 0.04) correlated with failure by multivariate analysis. Failed LCBDE was associated with increased length of stay (6.6 days vs. 3.1 days, P = 0.001), however the rate of serious complications or mortality was unaffected.ConclusionLCBDE is safe and effective in managing choledocholithiasis. Factors such as cystic duct diameter, size and number of CBD stones, and stone: cystic duct ratio are associated with increased likelihood of inadequate clearance. The presence of these factors can help clinicians in decision making during LCBDE to improve chance of success.
Outcomes of COVID‐19 in multiple myeloma patients treated with daratumumab
Authors: Jin Dian , He Jingsong , Wu Wenjun , Han Xiaoyan , Le Jing , Shu Wenxiu , Fu Jiaping , Kong Hongwei , Wang Gang , Zhou Xiujie , Qu Zhigang , Cai Zhen , He Donghua 
Published: October 2023

AbstractDespite concerns about an increased risk of adverse outcomes following coronavirus disease (COVID‐19) in multiple myeloma patients treated with anti‐CD38 Abs, the impact of COVID‐19 on this group of patients is unclear. We tried to evaluate the clinical outcomes of these patients. We collected data from 1036 patients with multiple myeloma and enrolled 509 cases with COVID‐19. We divided enrolled patients into daratumumab or nondaratumumab cohorts based on whether they had received daratumumab‐based treatment within 6 months of COVID‐19 infection. We applied a propensity score matching method to reduce the bias of baseline characteristics, and then compared the incidence of adverse outcomes between these two cohorts. A total of 117 patients were enrolled in the daratumumab cohort, and 392 patients in the nondaratumumab cohort. After propensity score matching, 204 patients were matched. The proportions of patients who developed COVID‐19 pneumonia (59.8% vs. 34.3%, p < 0.001), were hospitalized (33.3% vs. 11.8%, p < 0.001) and developed severe disease (23.5% vs. 6.9%, p = 0.001) were higher in the matched daratumumab cohort. By multivariate analysis, daratumumab exposure was an independent risk factor for severe disease. An ECOG performance status >2 and history of chronic kidney disease were independent risk factors for COVID‐19‐related mortality among patients who received daratumumab‐based therapy. This study suggested that multiple myeloma patients exposed to daratumumab were at a higher risk of adverse outcomes from COVID‐19.
Perspectives of parents partnering with physical therapists to deliver intensive rehabilitation for their young children with perinatal stroke: A qualitative study
Authors: Hurd Caitlin L. , Pritchard Lesley , Yang Jaynie F. 
Published: October 2023

AbstractBackgroundParental participation in their young children's rehabilitation has been promoted to increase intervention intensity, but parents' perspectives on increased involvement remain unclear. The objective of this study was to explore parents' experiences partnering with physical therapists (PTs) to administer early, intensive rehabilitation to their young children with cerebral palsy (CP).MethodsTwelve mothers and one father of children between 8 months and 3 years old with CP were interviewed. Semistructured interviews were conducted before and after parents partnered with a PT to deliver a 12 week activity‐based intervention targeting their child's lower extremities. The intervention occurred in the child's home and in PT clinical sites. Interviews were audio recorded and transcribed verbatim. Interpretive description was used as the methodological framework.ResultsThe three themes were (1) focus on maximizing the child's potential, (2) participation in intensive rehabilitation is challenging, and (3) the importance of a positive experience with therapy. Families discussed a number of barriers and facilitators to participating in intensive rehabilitation.ConclusionsThese results provide considerations for clinicians and researchers to facilitate meaningful engagement of parents in their young children's rehabilitation. This is especially important with increasing evidence for early, activity‐based interventions for young children with CP.
Endoscopic nasobiliary drainage versus endoscopic biliary stenting for preoperative biliary drainage in patients with malignant hilar biliary obstruction: Propensity score‐matched multicenter comparative study
Authors: Ishiwatari Hirotoshi , Kawabata Takanori , Kawashima Hiroki , Nakai Yousuke , Miura Shin , Kato Hironari , Shiomi Hideyuki , Fujimori Nao , Ogura Takeshi , Inatomi Osamu , Kubota Kensuke , Fujisawa Toshio , Takenaka Mamoru , Mori Hiroshi , Noguchi Kensaku , Fujii Yuki , Sugiura Teiichi , Ideno Noboru , Nakafusa Tomoki , Masamune Atsushi , Isayama Hiroyuki , Sasahira Naoki 
Published: October 2023

ObjectivesFor preoperative biliary drainage (PBD) of malignant hilar biliary obstruction (MHBO), current guidelines recommend endoscopic nasobiliary drainage (ENBD) due to the higher risk of cholangitis after endoscopic biliary stenting (EBS) during the waiting period before surgery. However, few studies have supported this finding. Therefore, we aimed to compare the outcomes of preoperative ENBD and EBS in patients with MHBO.MethodsPatients with MHBO who underwent laparotomy for radical surgery after ENBD or EBS were included from retrospectively collected data from 13 centers (January 2014 to December 2018). We performed a 1:1 propensity score matching between the ENBD and EBS groups. These patients were compared for the following: cholangitis and all adverse events (AEs) after endoscopic biliary drainage (EBD) until surgery, time to cholangitis development after EBD, postsurgical AEs, and in‐hospital death after surgery.ResultsOf the 414 patients identified, 355 were analyzed in this study (226 for ENBD and 129 for EBS). The matched cohort included 63 patients from each group. The proportion of cholangitis after EBD was similar between the two groups (20.6% vs. 25.4%, P = 0.67), and no significant difference was observed in the time to cholangitis development. The proportions of surgical site infections, bile leaks, and in‐hospital mortality rates were similar between the groups.ConclusionFor PBD of MHBO, the proportion of AEs, including cholangitis, after EBD until surgery was similar when either ENBD or EBS was used.