bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health of caregivers of children with medical complexity: group-based trajectory modelling
Authors: Nathwani Apsara Ali , Fayed Nora , Grandi Sonia M , Orkin Julia , Cohen Eyal 
Published: February 2024

ObjectiveTo describe the mental health trajectories of caregivers of children with medical complexity (CMC) and explore child characteristics associated with below-average caregiver mental health.DesignA secondary analysis of prospectively collected data from 123 caregivers of children aged <16 years with medical complexity from a multicentre randomised trial conducted from December 2016 to June 2021.Main outcome measureThe Patient-Reported Outcomes Measurement Information System Global Mental Health Scale was used to measure caregivers' self-reported mental health well-being. Group-based trajectory analysis was used to identify clusters of caregivers with similar changes in mental health across 24 months. Logistic regression was used to identify child-related predictors of mental health among caregivers.ResultsA final model with three distinct groups was selected, corresponding to caregivers with average (n=39), moderately below-average (n=65) and severely below-average (n=19) mental health scores, all with stable trajectories and high posterior probabilities (>90%). Moderately and severely below-average caregiver mental health groups, merged into one group, were associated with a greater number of child medical technology devices (adjusted OR (aOR) 1.44, 95% CI 1.01 to 2.04), gross motor difficulties (aOR 3.51, 95% CI 1.02 to 12.05) and worse child emotional (aOR 0.93, 95% CI 0.87 to 0.99) and psychological well-being (aOR 0.93, 95% CI 0.88 to 0.99).ConclusionMost caregivers of CMC reported persistently below-average mental health. The intensity of caregiving, as indicated by medical technology and child functional needs, is a potential risk factor for below-average caregiver mental health. Future design and evaluation of interventions focused on support for caregivers of CMC are warranted.
Optimal timing of influenza vaccination in young children: population based cohort study
Authors: Worsham Christopher M , Bray Charles F , Jena Anupam B 
Published: February 2024

Abstract

Objective
To assess optimal timing of influenza vaccination in young children.

Design
Population based cohort study.

Setting
United States.

Participants
Commercially insured children aged 2-5 years who were vaccinated against influenza during 2011-18.

Main outcome measure
Rates of diagnosis of influenza among children who were vaccinated against influenza, by birth month.

Results
Overall, 819 223 children aged 2-5 received influenza vaccination. Children vaccinated in November and December were least likely to have a diagnosis of influenza, a finding that may be confounded by unmeasured factors that influence the timing of vaccination and risk of influenza. Vaccination commonly occurred on days of preventive care visits and during birth months. Children born in October were disproportionately vaccinated in October and were, on average, vaccinated later than children born in August and earlier than those born in December. Children born in October had the lowest rate of influenza diagnosis (for example, 2.7% (6016/224 540) versus 3.0% (6462/212 622) for those born in August; adjusted odds ratio 0.88, 95% confidence interval 0.85 to 0.92).

Conclusions
In a quasi-experimental analysis of young children vaccinated against influenza, birth month was associated with the timing of vaccination through its influence on the timing of preventive care visits. Children born in October were most likely to be vaccinated in October and least likely to have a diagnosis of influenza, consistent with recommendations promoting October vaccination.
Factors influencing deceased organ donation rates in OECD countries: a panel data analysis
Authors: Qu Zhi , Oedingen Carina , Bartling Tim , Schrem Harald , Krauth Christian 
Published: February 2024

ObjectivesThis study aims to investigate factors with a significant influence on deceased organ donation rates in Organisation for Economic Co-operation and Development (OECD) countries and determine their relative importance. It seeks to provide the necessary data to facilitate the development of more efficient strategies for improving deceased organ donation rates.DesignRetrospective study.SettingPublicly available secondary annual data.ParticipantsThe study includes 36 OECD countries as panel members for data analysis.Outcome measuresMultivariable panel data regression analysis was employed, encompassing data from 2010 to 2018 for all investigated variables in the included countries.ResultsThe following variables had a significant influence on deceased organ donation rates: ‘opt-in’ system (β=−4.734, p<0.001, ref: ‘opt-out’ system), only donation after brain death (DBD) donors allowed (β=−4.049, p=0.002, ref: both DBD and donation after circulatory death (DCD) donors allowed), number of hospital beds per million population (pmp) (β=0.002, p<0.001), total healthcare employment pmp (β=−0.00012, p=0.012), World Giving Index (β=0.124, p=0.008), total tax revenue as a percentage of gross domestic product (β=0.312, p=0.009) and percentage of population aged ≥65 years (β=0.801, p<0.001) as well as high education population in percentage (β=0.118, p=0.017).ConclusionsCompared with the promotion of socioeconomic factors with a positive significant impact on deceased organ donation rates, the following policies have been shown to significantly increase rates of deceased organ donation, which could be further actively promoted: the adoption of an ‘opt-out’ system with presumed consent for deceased organ donation and the legal authorisation of both DBD and DCD for transplantation.
Adoption of technology enabled care to support the management of children and teenagers in rheumatology services: a protocol for a mixed-methods systematic review
Authors: Rostron Heather , Wright Judy M , Gilbert Anthony W , Dillon Beth , Pini Simon , Redmond Anthony C , Livermore Polly 
Published: February 2024

IntroductionCOVID-19 catalysed a rapid move to provide care away from the hospital using online communication platforms. Technology enabled care (TEC) continues to be an important driver in progressing future healthcare services. Due to the complex and chronic nature of conditions seen within paediatric rheumatology, TEC may lead to better outcomes. Despite some growth in published literature into the adoption of TEC in paediatric rheumatology, there is limited synthesis. The aim of this review is to provide a comprehensive understanding and evaluation of the adoption of TEC by patients in paediatric rheumatology services, to establish best practices.Methods and analysisThis proposed mixed-methods systematic review will be conducted by searching a wide variety of healthcare databases, grey literature resources and associated charities and societies, for articles reported in English language. Data extraction will include population demographics, technology intervention, factors affecting adoption of intervention and consequent study outcomes. A parallel-results convergent synthesis design is planned, with independent syntheses of quantitative and qualitative data, followed by comparison of the findings of each synthesis using a narrative approach. Normalisation process theory will be used to identify, characterise and explain implementation factors. The quality of included articles will be assessed using the Mixed Methods Appraisal Tool for research papers and the Authority, Accuracy, Coverage, Objectivity, Date, Significance checklist for grey literature. Overall confidence in quality and strength of evidence will be assessed using the Confidence in the Evidence from Reviews of Qualitative Research tool.Ethics and disseminationEthical approval is not required due to the nature of this mixed-methods systematic review. The findings will be disseminated via a peer-reviewed journal, relevant conferences and any other methods (eg, via NHS Trust or NIHR YouTube channels) as advised by paediatric rheumatology patients.PROSPERO registration numberCRD42023443058.
Does the implementation of a trauma system affect injury-related morbidity and economic outcomes? A systematic review
Authors: Bath Michael F , Hobbs Laura , Kohler Katharina , Kuhn Isla , Nabulyato William , Kwizera Arthur , Walker Laura E , Wilkins Tom , Stubbs Daniel , Burnstein RM , Kolias Angelos , Hutchinson Peter John , Clarkson P John , Halimah Sara , Bashford Tom 
Published: February 2024

BackgroundTrauma accounts for a huge burden of disease worldwide. Trauma systems have been implemented in multiple countries across the globe, aiming to link and optimise multiple aspects of the trauma care pathway, and while they have been shown to reduce overall mortality, much less is known about their cost-effectiveness and impact on morbidity.MethodsWe performed a systematic review to explore the impact the implementation of a trauma system has on morbidity, quality of life and economic outcomes, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All comparator study types published since 2000 were included, both retrospective and prospective in nature, and no limits were placed on language. Data were reported as a narrative review.ResultsSeven articles were identified that met the inclusion criteria, all of which reported a pre-trauma and post-trauma system implementation comparison in high-income settings. The overall study quality was poor, with all studies demonstrating a severe risk of bias. Five studies reported across multiple types of trauma patients, the majority describing a positive impact across a variety of morbidity and health economic outcomes following trauma system implementation. Two studies focused specifically on traumatic brain injury and did not demonstrate any impact on morbidity outcomes.DiscussionThere is currently limited and poor quality evidence that assesses the impact that trauma systems have on morbidity, quality of life and economic outcomes. While trauma systems have a fundamental role to play in high-quality trauma care, morbidity and disability data can have large economic and cultural consequences, even if mortality rates have improved. The sociocultural and political context of the surrounding healthcare infrastructure must be better understood before implementing any trauma system, particularly in resource-poor and fragile settings.PROSPERO registration numberCRD42022348529Level of evidenceLevel III.
Association of pulmonary hypertension with the outcome in patients undergoing edge-to-edge mitral valve repair
Authors: Ubben Timm , Frerker Christian , Fujita Buntaro , Rosenkranz Stephan , Pfister Roman , Baldus Stephan , Alessandrini Hannes , Kuck Karl-Heinz , Willems Stephan , Eitel Ingo , Schmidt Tobias 
Published: February 2024

ObjectivesThe association of pulmonary hypertension (PH) with the outcome after mitral transcatheter edge-to-edge repair (M-TEER) focusing on the new ESC/ERS guidelines definition for PH.BackgroundPH is frequently found in patients with mitral regurgitation and is associated with lower survival rates. Recent studies were based on echocardiographic parameters, but results based on invasive haemodynamics differentiating distinct types of PH using the new definition for PH are missing.Methods449 consecutive M-TEER-treated patients from December 2009 to February 2015 were included in this retrospective analysis. All patients were stratified by the distinct types of PH (no PH, precapillary PH, isolated postcapillary PH, combined post-PH and precapillary PH) according to the definitions of the ESC/ERS guidelines for the diagnosis of PH from 2015 (meanPA cut-off <25 mm Hg, pulmonary capillary wedge pressure (PCWP) cut-off ≤15 mm Hg, diastolic pulmonary gradient cut-off ≥7 mm Hg or pulmonary vascular resistance (PVR) >3 WU) and 2022 (meanPA cut-off ≤20 mm Hg, PCWP cut-off ≤15 mm Hg, PVR cut-off ≥3 WU).ResultsPatients with any type of PH (2015: meanPA cut-off 25 mm Hg; 2022: meanPA cut-off >20 mm Hg) showed a higher risk of death after M-TEER compared with patients with no PH (2015: HR 1.61 (95% CI 1.25 to 2.07); p<0.001 and 2022: HR 2.09 (95% CI 1.54 to 2.83); p<0.001). Based on the new PH definition, each PH subgroup showed a lower survival after M-TEER compared with patients with no PH. Echocardiographic estimated systolic PAP showed a correlation with invasively measured mean pulmonary artery pressure (mPAP) (r=0.29, p<0.001) and systolic pulmonary arterial pressure (r=0.34,p<0.001). Cox-regression analysis showed higher invasive diastolic, systolic and mean pulmonary pressures were associated with higher all-cause mortality (p<0.001). In addition, invasive measured higher right atrial pressure, lower pulmonary arterial compliance, higher PVR and higher wedge pressure were identified as predictors of all-cause mortality after M-TEER.ConclusionsThe new PH definition discriminates PH groups and mortality better than the old definition. The lower threshold of mPAP of 20mmHg improved prognostication in this cohort of patients.
Skeletal muscle mitochondrial capacity in patients with statin-associated muscle symptoms (SAMS)
Authors: Mangone Laura A. , Taylor Beth A. , Schmelzer Robert , Noh Sung Gi , White Michael C , Kwon Oh Sung , Thompson Paul D 
Published: February 2024

ObjectiveThe objective of this article is to evaluate near-infrared spectroscopy (NIRS), a non-invasive technique to assess tissue oxygenation and mitochondrial function, as a diagnostic tool for statin-associated muscle symptoms (SAMS).MethodsWe verified SAMS in 39 statin-treated patients (23 women) using a double-blind, placebo-controlled, cross-over protocol. Subjects with suspected SAMS were randomised to simvastatin 20 mg/day or placebo for 8 weeks, followed by a 4-week no treatment period and then assigned to the alternative treatment, either simvastatin or placebo. Tissue oxygenation was measured before and after each statin or placebo treatment using NIRS during handgrip exercise at increasing intensities of maximal voluntary contraction (MVC).Results44% (n=17) of patients were confirmed as having SAMS (11 women) because they reported discomfort only during simvastatin treatment. There were no significant differences in percent change in tissue oxygenation in placebo versus statin at all % MVCs in all subjects. The percent change in tissue oxygenation also did not differ significantly between confirmed and unconfirmed SAMS subjects on statin (−2.4% vs −2.4%, respectively) or placebo treatment (−1.1% vs −9%, respectively). The percent change in tissue oxygenation was reduced after placebo therapy in unconfirmed SAMS subjects (−10.2%) (p≤0.01) suggesting potential measurement variability.ConclusionsNIRS in the forearm cannot differentiate between confirmed and unconfirmed SAMS, but further research is needed to assess the usability of NIRS as a diagnostic tool for SAMS.Trial registration numberNCT03653663.
Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs
Authors: Pal Choudhuri Shreoshi , Girard Luc , Lim Jun Yi Stanley , Wise Jillian F. , Freitas Braeden , Yang Di , Wong Edmond , Hamilton Seth , Chien Victor D. , Kim Yoon Jung , Gilbreath Collin , Zhong Jun , Phat Sarah , Myers David T. , Christensen Camilla L. , Mazloom-Farsibaf Hanieh , Stanzione Marcello , Wong Kwok-Kin , Hung Yin P. , Farago Anna F. , Meador Catherine B. , Dyson Nicholas J. , Lawrence Michael S. , Wu Sihan , Drapkin Benjamin J. 
Published: February 2024

Abstract

Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires cross-resistance after relapse. This transformation is nearly inevitable in patients but has been difficult to capture in laboratory models. Here, we present a preclinical system that recapitulates acquired cross-resistance, developed from 51 patient-derived xenograft (PDX) models. Each model was tested in vivo against three clinical regimens: cisplatin plus etoposide, olaparib plus temozolomide, and topotecan. These drug-response profiles captured hallmark clinical features of SCLC, such as the emergence of treatment-refractory disease after early relapse. For one patient, serial PDX models revealed that cross-resistance was acquired through MYC amplification on extrachromosomal DNA (ecDNA). Genomic and transcriptional profiles of the full PDX panel revealed that MYC paralog amplifications on ecDNAs were recurrent in relapsed cross-resistant SCLC, and this was corroborated in tumor biopsies from relapsed patients. We conclude that ecDNAs with MYC paralogs are recurrent drivers of cross-resistance in SCLC.

Significance:
SCLC is initially chemosensitive, but acquired cross-resistance renders this disease refractory to further treatment and ultimately fatal. The genomic drivers of this transformation are unknown. We use a population of PDX models to discover that amplifications of MYC paralogs on ecDNA are recurrent drivers of acquired cross-resistance in SCLC.
This article is featured in Selected Articles from This Issue, p. 695
Tapete vermelho: o olhar e a viagem na construção do lugar cinemático
Authors: Silva Rodrigo 
Published: February 2024

La película brasileña Alfombra Roja (2006), dirigida por Luiz Alberto Pereira, es la producción cinematográfica elegida para acercar la ciencia geográfica y el arte cinematográfico. Será el hilo conductor, la carretera imaginaria de este viaje de la mirada . La aventura se despliega en las tensiones culturales entre el campo y la ciudad. El montaje de la película es una construcción pertinente que denota las tensiones sociales y culturales de estos dos espacios. Tapete Vermelho es un cruce de dos ex
tremos, Brasil es un cruce complejo de varios extremos. Un camino que comienza en la tradición, resiste y llega a la modernidad, que a su vez asombra y seduce. Los paisajes sociales y culturales brasileños se convierten en ingredientes escénicos que solidifican el significado de la experiencia de la mirada. Los lugares geográficos se convierten en lugares narrativos, por lo que las imágenes cinematográficas crean subjetividades espaciales
y viceversa. Las describimos y las analizamos a partir de la observación para entender cóm o la técnica
cinematográfica elabora la antropomorfización espacial.
Incident Cardiovascular Disease in Women With Type 1 or Type 2 Diabetes Following a Hypertensive Disorder of Pregnancy
Authors: Mattsson Kristina , Pihlsgård Mats , Enhörning Sofia , Timpka Simon 
Published: February 2024

BACKGROUND:
The extent to which a history of hypertensive disorders of pregnancy is associated with incident cardiovascular disease also among women with diabetes is unknown.

METHODS:
In this nationwide register-based cohort study, parous women aged 18 to 69 years with a first delivery in the Swedish Medical Birth Register, regardless of diabetic status at that time, and a subsequent clinical visit in the Swedish National Diabetes Register were included. Time to first cardiovascular disease event (myocardial infarction, stroke, or heart failure) before age 70 years by hypertensive disorders of pregnancy history was separately analyzed by diabetes type using Cox regression models that included conventional risk factors.

RESULTS:
In total, 1748 (18.9%) of 9230 women with type 1 and 5904 (10.6%) of 55 773 women with type 2 diabetes had their first delivery complicated by a hypertensive disorder of pregnancy. Median time (25–75th percentile) between first delivery and start of follow-up was 3.3 (1.4–13.0) years for women with type 1 and 29.8 (22.4–35.6) years for women with type 2 diabetes. In modeling, the risk for any cardiovascular disease event among women with a history of hypertensive disorders of pregnancy was generally 10% to 20% higher, with main models estimating hazard ratios to 1.20 (95% CI, 0.99–1.47) for women with type 1 and 1.15 (95% CI, 1.02–1.29) for women with type 2 diabetes.

CONCLUSIONS:
In women with diabetes, a history of hypertensive disorders of pregnancy was associated with an increased risk of incident cardiovascular disease and should be considered as a risk enhancer.
Using OSSEs to Evaluate GXS Impact in the Context of International Coordination
Authors: McGrath-Spangler Erica L. , Privé N. C. , Karpowicz Bryan M. , Moradi Isaac , Heidinger Andrew K. 
Published: February 2024

Abstract
The Geostationary Extended Observations (GeoXO) program plans to include a hyperspectral infrared (IR) sounder on its central satellite, expected to launch in the mid-2030s. As part of the follow-on to the GOES program, the NOAA/NASA GeoXO Sounder (GXS) instrument will join several international counterparts in a geostationary orbit. In preparation, the NASA Global Modeling and Assimilation Office (GMAO) assessed the potential effectiveness of GXS both as a single GEO IR sounder and as part of a global ring that includes international partners. Using a global observing system simulation experiment (OSSE) framework, GXS was assessed from a numerical weather prediction (NWP) perspective. Evaluation of the ability of GXS, both alone and as part of a global ring of GEO sounders, to improve weather prediction of thermodynamic variables was performed globally and regionally. GXS dominated regional analysis and forecast improvements and contributed significantly to global increases in forecast skill relative to a Control. However, more sustained global improvements, on the order of 4 days, relied on international partnerships. Additionally, GXS showed the capability to improve hurricane forecast track errors on the time scales necessary for evacuation warnings. The FSOI metric over CONUS showed that the GXS observations provided the largest radiance impact on the moist energy error norm reduction. The high-temporal-resolution atmospheric profile information over much of the Western Hemisphere from GXS provides an opportunity to improve the representation of weather systems and their forecasts.

Significance Statement
NOAA and NASA are currently planning the GeoXO mission as a follow-on to the GOES program. As part of this process, NASA’s Global Modeling and Assimilation Office has performed several experiments using an observing system simulation experiment (OSSE) framework to assess the potential impact of the GeoXO Sounder (GXS) on numerical weather prediction within the context of international partners launching similar instruments. As part of this assessment, it was found that assimilation of GXS data has the ability to improve both the model analyzed weather and forecasts of the weather, specifically over the domain that GXS observes. Global improvements relied more heavily on a solution consisting of multiple instruments to form a global ring.