bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Non‐Invasive Method to Monitor and Reverse Faradaic Imbalance in Redox Flow Batteries
Authors: Cantera Miguel , Cavusoglu Koray , Lubián Lara , Rubio‐Presa Rubén , Sanz Roberto , Ruiz Virginia , María Cámara Jose , Ventosa Edgar 
Published: January 2025

AbstractAqueous Organic Redox Flow Batteries (AORFBs) have received much attention due to the accessibility of their active materials. However, among the key performance indicators that require improvement for AORFBs to become competitive against mature technologies, lifespan is especially critical for stationary energy storage. Faradaic imbalance driven by the occurrence of irreversible electrochemical processes decreases lifespan, so monitoring and correction of this parameter is required to prolong lifespan. This work presents a novel, simple and non‐invasive automatized method to monitor the Faradaic imbalance. This method is based on detecting the variation of the minimum derivative of the cell voltage upon cycling, and it is used as the activation criterion for a rebalancing device. The system is tested using an alkaline flow battery consisting of ferrocyanide and 2,6‐dihydroxyanthraquinone (2,6‐DHAQ), extending the cycle life of the battery to 400 cycles (235 h) without any capacity decay and without Ar‐filled glovebox. This demonstrates the feasibility of the proposed system to monitor the state‐of‐health (SOH) due to Faradaic imbalance and recover the capacity loss.
Involvement of metformin and aging in salivary expression of ACE2 and TMPRSS2
Authors: Shikama Yosuke , Otsuka Kunihiro , Shikama Yuka , Furukawa Masae , Ishimaru Naozumi , Matsushita Kenji 
Published: January 2025

AbstractSARS‐CoV‐2‐related proteins, ACE2 and TMPRSS2, are determinants of SARS‐CoV‐2 infection. Although these proteins are expressed in oral‐related tissues, their expression patterns and modulatory mechanisms in the salivary glands remain unknown. We herein showed that full‐length ACE2, which has both a fully functional enzyme catalytic site and high‐affinity SARS‐CoV‐2 spike S1‐binding sites, was more highly expressed in salivary glands than in oral mucosal epithelial cells and the lungs. Regarding TMPRSS2, zymogen and the cleaved form were both expressed in the salivary glands, whereas only zymogen was expressed in murine lacrimal glands and the lungs. Metformin, an AMPK activator, increased stimulated saliva secretion and full‐length ACE2 expression and decreased cleaved TMPRSS2 expression in the salivary glands, and exerted the same effects on soluble ACE2 (sACE2) and sTMPRSS2 in saliva. Moreover, metformin decreased the expression of beta‐galactosidase, a senescence marker, and ADAM17, a sheddase of ACE2 to sACE2, in the salivary glands. In aged mice, the expression of ACE2 was decreased in the salivary glands, whereas that of sACE2 was increased in saliva, presumably by the up‐regulated expression of ADAM17. The expression of TMPRSS2 in the salivary glands and sTMPRSS2 in saliva were both increased. Collectively, these results suggest that the protein expression patterns of ACE2 and TMPRSS2 in the salivary glands differ from those in other oral‐related cells and tissues, and also that metformin and aging affect the salivary expression of ACE2 and TMPRSS2, which have the potential as targets for preventing the transmission of SARS‐CoV‐2.
Eco‐Friendly Fabrication of FeS2 QD‐Chitosan Biopolymer Composites: Green Synthetic Approach
Authors: Sharma Aditi , Tharuny S. , Pandey Tejasvi , Pandey Vivek 
Published: January 2025

ABSTRACTIn this paper, we offer a unique green synthetic approach for producing iron sulfide quantum dots (FeS2 QD)‐chitosan composites using gel chemistry. The technique uses the environmental features of chitosan, a biocompatible and biodegradable polysaccharide, and the excellent electrical properties of FeS2 QDs. By sustainable chemistry principles, the synthesis process is carried out under gentle settings, using aqueous solutions and avoiding hazardous solvents and strong chemicals. The resulting FeS2 QD‐chitosan composite has superior structural integrity, homogeneous QD distribution, and improved physicochemical characteristics. Comprehensive characterization techniques, such as X‐ray diffraction (XRD), Fourier‐transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and photoluminescence spectroscopy, confirm the successful integration of FeS2 QDs into the chitosan matrix while preserving their quantum properties. This work demonstrates the viability of gel chemistry as a green synthetic technique for generating functional nanocomposites, providing a scalable and environmentally responsible option for advanced material development.
Integrating ESG Factors Into Cost‐Efficiency Frontier: Evidence From the European Listed Banks
Authors: Algeri Carmelo , Brighi Paola , Venturelli Valeria 
Published: January 2025

ABSTRACTThis paper provides the first in‐depth analysis of the effects of incorporating environmental, social, and governance (ESG) factors into the cost‐efficiency frontier of banks. Drawing on both shareholder and stakeholder theories, the research addresses the increasing regulatory and market pressures for banks to incorporate ESG components into their operational processes. Using data from 42 European listed banks spanning the 2006–2021 period and a stochastic frontier approach (SFA), the study introduces two novel ESG‐related variables in the stochastic frontier function: (i) a variable measuring the contribution of ESG factors to banking output production and (ii) a variable measuring the risks associated with ESG controversies. Additionally, it evaluates the impact of executive remuneration tied to ESG goals on cost efficiency, addressing a critical gap in the literature. The findings reveal that ESG‐related frontier variables significantly influence the banks' cost function. Furthermore, the results show that banks with a stronger commitment to ESG principles achieve higher cost efficiency in the long term, despite short‐term cost increases associated with ESG investments. Moreover, the results highlight that executive compensation linked to ESG targets negatively affects cost efficiency. By filling these gaps, the paper significantly contributes to the literature, offering valuable insights for bank managers tasked with balancing short‐term costs against long‐term efficiency gains through strategic ESG investments.
When Trust and Distrust Come Into Play: How Green Concern, Scepticism and Communication Affect Customers' Behaviour?
Authors: Tetrevova Libena , Kotkova Striteska Michaela , Kuba Ondrej , Prakash Vineeth , Prokop Viktor 
Published: January 2025

ABSTRACTWhat happens when already sceptical customers start questioning company communication? Encouraged by the vague answers to this question, our study extends existing knowledge about the effects of customers' environmental concern, scepticism and communication on green purchasing intention (GPI) and green purchasing behaviour (GPB) across environmentally controversial industries—namely, textile and clothing and food industries. Using our own primary data collected in November 2023 and covering 1001 customers in the Czech Republic, where the issue of sustainability is generally on the back burner, we show that customers' increased environmental concern can completely change the relationship between environmental scepticism and GPI, thereby leading to positive effects. What is interesting and new is the finding that trust and distrust can act as significant mediators of the relationships investigated thus far. Moreover, as soon as customers start to examine companies' practices and their credibility in more detail, the previously positive relationship between environmental communication and GPI can become negative.
Gut Microbiome as a Potential Marker of Hematologic Recovery Following Induction Therapy in Acute Myeloid Leukemia Patients
Authors: Salvestrini Valentina , Conti Gabriele , D'Amico Federica , Cristiano Gianluca , Candela Marco , Cavo Michele , Turroni Silvia , Curti Antonio 
Published: January 2025

ABSTRACTBackgroundThe management of acute myeloid leukemia (AML) is hindered by treatment‐related toxicities and complications, particularly cytopenia, which remains a leading cause of mortality. Given the pivotal role of the gut microbiota (GM) in hemopoiesis and immune regulation, we investigated its impact on hematologic recovery during AML induction therapy.MethodsWe profiled the GM of 27 newly diagnosed adult AML patients using 16S rRNA amplicon sequencing and correlated it with key clinical parameters before and after induction therapy.ResultsOur investigation revealed intriguing associations between the GM composition and crucial recovery indicators, including platelet, lymphocyte, and neutrophil counts, and identified early GM signatures predictive of improved hematologic recovery. Remarkably, patients demonstrating superior recovery had higher alpha diversity and enrichment in health‐associated taxa belonging to the genera Faecalibacterium, Ruminococcus, Blautia, and Butyricimonas at diagnosis.ConclusionsDespite certain study limitations, our findings suggest that evaluating GM features could serve as a potential marker for hematologic recovery. This preliminary work opens avenues for personalized risk assessment and interventions, possibly involving GM modulation tools, to optimize recovery in AML patients undergoing induction therapy and potentially enhancing overall outcomes in individuals with hematologic diseases.
Association of Pretreatment Serum Indirect Bilirubin Levels With Prognostic and Therapeutic Value in Patients With Newly Diagnosed Acute Myeloid Leukemia
Authors: Kong Chunfang , Hu Linhui , Zhang Ling , Cheng Hongbo , Lu Qilin , Li Anna , Ke Bo , Cui Wenting , Zhang Huixia , Wu Mei , Zhu Qingqing , Jin Chenghao , Yu Li 
Published: January 2025

ABSTRACTBackgroundBilirubin has anti‐inflammatory, antioxidant, and anti‐cancer properties, with an inverse relationship between its levels and cancer risk and prognosis. However, the prognostic value of serum bilirubin in acute myeloid leukemia (AML) remains uncertain.MethodsThis retrospective study analyzed pretreatment serum total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) in 284 AML patients and 316 healthy controls. The prognostic significance of serum bilirubin levels was determined using the Kaplan–Meier method and Cox proportional hazards model.ResultsPretreatment TBIL and IBIL levels were significantly lower in AML patients compared to controls. TBIL and IBIL levels were significantly higher in the CR/CRh/CRi group than in the non‐CR/CRh/CRi group and increased significantly after chemotherapy. Elevated pretreatment TBIL and IBIL were associated with longer overall survival (OS) (p < 0.05) and progression‐free survival (PFS) (p < 0.05). Pretreatment IBIL was an independent prognostic factor for OS (hazard ratio [HR], 0.47; 95% confidence interval [CI] 0.28–0.79; p < 0.05) and PFS (HR, 0.53; 95% CI 0.33–0.85; p < 0.05).ConclusionElevated pretreatment IBIL levels are correlated with improved OS and PFS, acting as an independent favorable prognostic indicator for AML.
The Role of Aryl Hydrocarbon Receptor in Skin Homeostasis: Implications for Therapeutic Strategies in Skin Disorders
Authors: Yang Jundan , Qiao Pei , Wang Gang , Dang Erle 
Published: January 2025

ABSTRACTThe aryl hydrocarbon receptor (AhR), a ligand‐activated transcription factor, is extensively expressed in diverse human organs and plays a pivotal role in mediating the onset, progression, and severity of numerous diseases. Recent research has explored the substantial impact of AhR on skin homeostasis and related pathologies. As a multi‐layered organ, the skin comprises multiple cell populations that express AhR. In this review, we introduce the role of AhR in various skin cells and its impact on skin barrier function. Furthermore, we explore the involvement of AhR in the development of various skin diseases, highlighting its potential as a therapeutic target for skin disorders. By targeting AhR, we may open new avenues for the development of novel and efficient skin disease treatments.
Hepatic Rupture in HELLP Syndrome: Report of Two Patients and a Review of Peripartum Surgical Care and Transfusion
Authors: Larson Sarah N. , Killeen Trevor F. , Bowman Laura , Shankar Sruthi , Stock Emily , Welton Lindsay , Harmon James V. 
Published: January 2025

ABSTRACTHerein, we report the cases of two patients with hemolysis, elevated liver enzymes, and low platelets syndrome who underwent emergent Cesarean sections that were complicated by massive hemorrhage due to undiagnosed hepatic rupture. Intraoperative General Surgery team intervention, early activation of massive transfusion protocol, hemostatic resuscitation, and transfer to ICU resulted in the survival of both patients.
Unveiling the Catalytic Activity of Nickel(II) Complexes of Pentadentate Ligands in Aromatic Oxidations
Authors: Rajeev Anjana , Muthuramalingam Sethuraman , Murugan Visvesvarar Pitchai , Costas Miquel , Vadivelu Prabha , Sankaralingam Muniyandi 
Published: January 2025

AbstractSelective oxidation of aromatic substrates to phenols is a challenging goal in synthetic chemistry. Herein, we investigate the catalytic activity of nickel(II) complexes of the type [Ni(L)(CH3CN)](X)2 (1–4); (X = ClO4−, BPh4−, L = N4Py, BnTPEN, and BnImDPEN) supported by pentadentate ligands in the hydroxylation of aromatic substrates to corresponding phenols using H2O2. In benzene oxidation, complex 2 showed a phenol yield of 28% and a turnover number of 560 with 99% selectivity. Also, preferential oxidation of aromatic C─H bonds over aliphatic C─H bonds was noted during the oxidation of substituted benzenes. The kinetic isotope effect value (1.01) supported the involvement of nickel‐bound oxygen species in the catalytic cycle rather than hydroxyl radicals. The key source of oxygen in the formed phenol was found to be H2O2 based on the isotope‐labelling experiments using H218O2 and H218O. Although the formation of {[(BnTPEN)Ni(OOH)]+ + NCCH3}+ intermediate was identified upon reacting complex 2 with H2O2, this species did not directly react with benzene to form phenol. Further, DFT studies suggested that the species [(L)NiII(O•)]+ derived from O─O homolysis of nickel(II) hydroperoxo intermediate reacts with benzene to produce phenol and the presence of a nickel‐based oxidant is the reason behind the excellent selectivity.
Tailoring Electrocarboxylation Pathways on Lead Cathodes: Insights into Electrolysis Mode
Authors: Bruggeman D. F. , Zwart M. , Garcia A. C. 
Published: January 2025

AbstractElectrocarboxylation, the electrochemical addition of CO2 to organic substrates using renewable energy, offers a promising approach for carbon capture and utilization. However, commercial viability remains limited due to poor product selectivity and yields. In this work, we investigate how the electrolysis mode – chronoamperometry (CA) versus chronopotentiometry (CP) – influences the electrocarboxylation mechanisms of phenyl‐activated substrates, Benzaldehyde, Styrene, and Benzylbromide, on Lead electrodes. By employing cyclic voltammetry (CV), in situ FTIR, and bulk electrolysis, we explore how these modes affect product selectivity and reaction efficiency. Our results show that substrate‐activated mechanisms, such as those observed for Benzaldehyde and Benzylbromide, achieve higher selectivity and reduced side‐product formation under CA conditions, while CP leads to increased side reactions. In contrast, Styrene exhibits more complex behavior, with CP favoring di‐carboxylation, while CA enhances mono‐carboxylation. These findings highlight the significant impact of electrolysis mode on controlling electrocarboxylation pathways, providing valuable insights for optimizing selective and efficient synthesis processes.
Construction of Sub‐Nano Channels of Amino Pillar[6]arene Inspired Biomimetic Porous Roots for Specific Remove of Imazamox
Authors: Chen Xingyu , Wang Yue , Luan Hanghang , Xu Weiwei , Li Guang , Qu Haonan , Zhang Haifan , Ma Cuiguang , He Qiang , Bahojb Noruzi Ehsan , Cheng Jing , Lu Zhiyan , Periyasami Govindasami , Zhang Jin , Quan Jiaxin , Zhou Chuan , Li Haibing 
Published: January 2025

AbstractThe root ducts play an important role in the plant's transport of nutrients from the soil. Based on the selective transport characteristics of plant roots, amino pillar[6]arene bionic porous root sub‐nano channel membrane were constructed to remove Imazamox. Imazamox (IM) is an effective imidazolinone herbicide frequently utilized in soybean fields to control a wide range of annual grasses and broad‐leaved weeds. However, it is important to note that while IM is effective in controlling the growth of weeds, its residues can affect the plants that are later planted. Developing a material that can efficiently and selectively remove IM from the environment poses a significant challenge in the realm of agricultural residue removal. A layer‐upon‐layer covalent assembly was formed through the reaction of amino pillar[6]arene with terephthalaldehyde using an aldehyde‐amine Schiff‐base reaction. The cavity of amino pillar[6]arenal is used to realize the host‐guest interaction of IM. This enabled the development of a membrane with high selectivity for the extraction and removal of IM. The removal rate is 4.66–21.91 times higher than that of other pesticide chemicals. The successful development of the highly selective porous root bionic membrane provides a broad prospect for its application and development in agricultural production.
Global and Local Shielding/Deshielding Variation in C60 and C70 Fullerenes Upon Reduction: Evaluation of Aromaticity, 13C‐NMR and Anisotropy Patterns
Authors: Charistos Nickolas D. , Lawrence Samuel R. , Muñoz‐Castro Alvaro 
Published: January 2025

AbstractFullerenes are statically pleasant species featuring symmetric cages, which can be modified upon reduction. Here, we theoretically account for the variation of 13C‐NMR patterns in C60 and C70 upon six‐fold reduction and the overall variation of the enabled shielding/deshielding regions induced by π and σ electrons according to different orientations of the external field and the related anisotropy. Our results show a significant modification of the chemical shift given by the main variation of the σ33 (or δ33) shielding component under the principal axis system (PAS) of the chemical shift anisotropy (CSA) at the representative carbon nucleus. For C606− a shielding cone property is enabled from any orientation, accounting for a significant spherical aromatic character. In contrast, in C706−, a shielding cone is reserved only for an axial‐oriented field, with a deshielding cone behavior obtained from the complementary equatorial orientations. The overall anisotropy shows an inner isotropic region for C60 and C606−, with a continuous anisotropic outer contour for the latter. In contrast, C70 and C706− both show larger anisotropies, given the lesser spherical shape in addition to the modified π‐surface. Such information is useful for further rationalizing the implementation of magnetic anisotropic molecular devices into fullerene‐based materials.
Single‐molecule Magnet Properties of Silole‐ and Stannole‐ligated Erbium Cyclo‐octatetraenyl Sandwich Complexes
Authors: De Siddhartha , Mondal Arpan , Chen Yan‐Cong , Tong Ming‐Liang , Layfield Richard A. 
Published: January 2025

AbstractThe synthesis, structures and magnetic properties of an η5‐silole complex and an η5‐stannole complex of erbium are reported. The sandwich complex anions [(η5‐CpSi)Er(η8‐COT)]– and [(η5‐CpSn)Er(η8‐COT)]–, where CpSi is [SiC4‐2,5‐(SiMe3)2‐3,4‐Ph2]2– (1Si), CpSn is [SnC4‐2,5‐(SiMe3)2‐3,4‐Me2]2– (1Sn) and COT=cyclo‐octatetraenyl, were obtained as their [K(2.2.2‐cryptand)]+ salts and found to be isostructural, with remarkably similar bond lengths and angles, differing only in the lengths of the Er–E interactions (E=Si, Sn). The parallels in the molecular structures of 1Si and 1Sn are reflected in their dynamic magnetic properties, which show single‐molecule magnet behaviour in zero applied field, with effective energy barriers of 115±7 and 125±3 cm–1, respectively, along with comparable magnetic relaxation times. Analysis of the two complexes using ab initio calculations reveals differences at a quantitative level, but overall similar electronic structures, with the thermally activated relaxation likely to proceed via the first‐excited Kramers doublet. Comparing 1Si and 1Sn with the previously reported germanium analogue 1Ge reveals that swapping one heavier group 14 element for another in complexes of the type [(η5‐CpE)Er(η8‐COT)]– has a minimal impact on the SMM behaviour.
Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double‐blind, double dummy, randomized crossover trial
Authors: Arthur Joseph A. , Reddy Akhila , Popat Uday , Halm Josiah , Vaughan‐Adams Nicole , Myers Alan , Yang Peiying , De Moraes Aline Rozman , Laureano Raul , Lopez‐Quinones Irma , Urbauer Diana , Hui David , Bruera Eduardo 
Published: January 2025

AbstractBackgroundThere is much concern that opioids administered as intravenous (iv) bolus for pain relief may inadvertently increase their risk for abuse. However, there is insufficient data to support this. The authors compared the abuse liability potential, analgesic efficacy, and adverse effect profile of fast (iv push) versus slow (iv piggyback) administration of iv hydromorphone among hospitalized patients requiring iv opioids for pain.MethodsIn this double‐blind, double dummy, randomized, 2 × 2 crossover trial, patients with ≥4 cancer‐related pain were randomly assigned to receive either iv hydromorphone 1 mg administered over 2 minutes (fast iv push) or 15 minutes (slow iv piggyback) during the first treatment period. Participants crossed over to receive the alternate treatments during the second period after a 6‐hour washout period.ResultsEighty‐three eligible patients were allocated to slow–fast (42, 51%) or fast–slow (41, 49%). Both treatments produced low abuse potential scores with no difference between them (mean peak Drug Effect Questionnaire “drug liking” subscale of fast [24.00] vs. slow [24.34], p = .82). A total of 92% and 94% of slow and fast iv hydromorphone recipients, respectively, had similar improvements in pain scores over 120 minutes (odds ratio, 0.67; 95% confidence interval, 0.06–5.82, p = .65). Drowsiness was more frequent with the fast than the slow rate (50% vs. 29% at 15 minutes [p = .03] and 52% vs. 31% at 60 minutes [p = .03]).ConclusionsSlow iv hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the slow infusion may be considered as a first‐line modality for iv opioid administration in hospitalized patients requiring intermittent opioids for pain.