bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time required to achieve clinically significant outcomes after arthroscopic superior capsular reconstruction
Authors: Ben Hui , Zeng Chu Hui , Kholinne Erica , Ryu Seung Min , Ling Jian Loong , Koh Kyoung‐Hwan , Jeon In‐Ho 
Published: November 2023

AbstractPurposeTo investigate the time‐dependent nature of clinically significant outcomes, including the minimal clinically important difference (MCID), substantial clinical benefit, and Patient Acceptable Symptomatic State (PASS) after arthroscopic superior capsular reconstruction, and the factors contributing to the achievement of early clinically significant outcomes.MethodsPatients who underwent ASCR between March 2015 and September 2020 with complete preoperative and postoperative 6‐month, 1‐year, and 2‐year patient‐reported outcome measures (PROMs) were retrospectively analysed. Threshold values for MCID, substantial clinical benefit, and PASS were obtained from the previous literature for the PROMs. The time required to achieve clinically significant outcomes was calculated using Kaplan–Meier analysis. Multivariate Cox regression was performed to evaluate the variables predictive of an earlier or delayed achievement of MCID.ResultsFifty‐nine patients with a mean age of 64.5 ± 8.7 years old were included. The time of mean achievement of MCID, substantial clinical benefit, and PASS for VAS was 11.2 ± 0.9, 16.3 ± 1.1, and 16.6 ± 0.9 months, respectively. The time of mean achievement of MCID, substantial clinical benefit, and PASS for ASES was 13.2 ± 1.0, 16.8 ± 1.0, and 18.3 ± 0.9 months, respectively. The time of mean achievement of MCID, substantial clinical benefit, and PASS for the Constant score was 11.6 ± 0.9, 15.1 ± 1.0, and 14.7 ± 0.9 months, respectively. The time of mean achievement of MCID, substantial clinical benefit, and PASS for SANE was 14.4 ± 1.0, 16.1 ± 1.0, and 15.5 ± 0.8 months, respectively. Patients with a higher preoperative VAS score achieved an earlier MCID for VAS (P = 0.014). However, patients with a higher preoperative ASES and SANE scores achieved delayed MCID for ASES and SANE (P = 0.026, and P < 0.001, respectively).ConclusionMost patients achieved MCIDs around 1 year after arthroscopic superior capsular reconstruction. A higher preoperative VAS score favours faster MCID achievement, while higher preoperative ASES and SANE scores contribute to delayed MCID achievement.Study designCohort studyLevel of evidenceLevel IV.
Pathophysiology and Treatment of Intraseptal-Course Left Coronary Anomaly: Surgery for All?
Authors: Angelini Paolo , Uribe Carlo , Corno Antonio F. 
Published: November 2023

Abstract
Intraseptal-course, ectopic coronary anomalies are not well characterized as to anatomy, function, prognosis, and treatment. Recently, a revolutionary but unsupported new theory is claiming that most patients with a Left Anomalous Coronary Artery originating from the Opposite Sinus with anomalous Intra-Septal course (L-ACAOS-IS)—even small children—have significant stenoses and require open-heart surgery to prevent acute myocardial infarction and death. This surprising view has spurred ongoing discussions among adult and pediatric cardiologists and cardiac surgeons, compelling us (the conservative party in the discussion) to offer an in-depth and comprehensive review of this anomaly, based on objective but opposite data. We and other adult cardiologists have followed numerous L-ACAOS-IS patients for many years and have observed none of the claimed catastrophes. Rather, we have consistently found that L-ACAOS-IS generally has a benign clinical prognosis. We present the general principle of coronary artery dysfunction in anatomical congenital anomalies (that only significant luminal coronary stenosis can have clinical repercussions). We then review anatomical and functional details of L-ACAOS-IS related to prognosis and treatment indications, which could explain many of the clinical presentations recently mentioned. Finally, we encourage our more liberal colleagues to recognize that, compared with normal coronary arteries, those with anomalies of origin and course are associated with frequent coronary spasm. In particular, we underscore that some of the ischemic manifestations and other results might actually be caused by pressure wire–induced artifacts (rigid wires tend to cause coronary spasm when advanced into tortuous coronary arteries).
Laparoscopic partial versus radical nephrectomy for localized renal cell carcinoma over 4 cm
Authors: Sun Zi-Jun , Liu Feng , Wei Hai-Bin , Zhang Da-Hong 
Published: November 2023

Abstract
Purpose
To compare the long-term clinical and oncologic outcomes of laparoscopic partial nephrectomy (LPN) and laparoscopic radical nephrectomy (LRN) in patients with renal cell carcinoma (RCC) > 4 cm.

Methods
We retrospectively reviewed the records of all patients who underwent LPN or LRN in our department from January 2012 to December 2017. Of the 151 patients who met the study selection criteria, 54 received LPN, and 97 received LRN. After propensity-score matching, 51 matched pairs were further analyzed. Data on patients’ surgical data, complications, histologic data, renal function, and survival outcomes were collected and analyzed.

Results
Compared with the LRN group, the LPN group had a longer operative time (135 min vs. 102.5 min, p = 0.001), larger intraoperative bleeding (150 ml vs. 50 ml, p < 0.001), and required longer stays in hospital (8 days vs. 6 days, p < 0.001); however, the level of ECT-GFR was superior at 3, 6, and 12 months (all p < 0.001). Similarly, a greater number of LRN patients developed CKD compared with LPN until postoperative 12 months (58.8% vs. 19.6%, p < 0.001). In patients with preoperative CKD, LPN may delay the progression of the CKD stage and even improve it when compared to LRN treatment. There were no significant differences between the two groups for OS, CSS, MFS, and PFS (p = 0.06, p = 0.30, p = 0.90, p = 0.31, respectively). The surgical method may not be a risk factor for long-term survival prognosis.

Conclusion
LPN preserves renal function better than LRN and has the potential value of significantly reducing the risk of postoperative CKD, but the long-term survival prognosis of patients is comparable.
Milestones and turning points in the experience of physical activity throughout cancer care: a qualitative study to inform physical activity promotion
Authors: St-Cyr Jany , Saint-Onge Kadia , Doré Isabelle , Gauvin Lise 
Published: November 2023

Abstract
Purpose
Physical activity (PA) is an important supportive care strategy to manage cancer and treatment-related side effects, yet PA participation is low among people diagnosed with cancer. This study examined patients’, health professionals’, and managers’ perspectives on PA throughout cancer care to glean implications for PA promotion.

Methods
Random selection and purposeful sampling methods allowed for the recruitment of 21 patients (76.2% women) and 20 health professionals and managers (80% women) who participated in individual semi-structured interviews. Interview questions explored facilitators and barriers to PA participation and promotion across the cancer care continuum. Interviews were audio-recorded and transcribed. Then, qualitative thematic analysis was performed.

Results
The analysis produced five main themes describing milestones in PA participation throughout cancer care: (1) Getting Started, (2) Discovering PA Resources, (3) Taking Action, (4) Striving for Change, and (5) Returning to a “New Normal.” The sub-themes underscored turning points, i.e., tasks and challenges to PA participation that had to be overcome at each milestone. Achieving milestones and successfully navigating turning points were dependent on clinical, social, and community factors.

Conclusion
Cancer patients appear to progress through a series of milestones in adopting and maintaining PA throughout cancer care. Intervention strategies aimed at promoting PA could test whether support in navigating turning points could lead to greater PA participation. These findings require replication and extension, specifically among patients who are men, younger adults, and culturally diverse.
Modification of stability properties of yttrium(III) oxide particles by simultaneous adsorption of poly(acrylic acid) and poly(ethylene glycol) for possible applications in wastewater treatment
Authors: Wiśniewska Małgorzata , Herda Karolina , Urban Teresa , Nowicki Piotr , Woszuk Agnieszka 
Published: November 2023

AbstractThe adsorption, electrokinetic and stability properties of yttrium(III) oxide—Y2O3 in mixed solutions of macromolecular compounds were investigated. The interfacial behavior of poly(acrylic acid)-PAA and poly(ethylene glycol)—PEG in single and binary systems was examined in the pH range 3–10. The polymers used were characterized by different ionic nature—the PAA is an anionic polymer, whereas PEG belongs to the group of non-ionic polymers. Based on the results obtained, the most probable mechanisms for the binding of PAA and PEG macromolecules on the yttrium(III) oxide surface were proposed. In addition, the analysis of adsorption and electrokinetic data enabled explanation of the obtained changes in the stability of Y2O3 suspensions without and in the presence of PAA or/and PEG, as well as determination of the specific stabilization-destabilization mechanisms of the studied systems. It was shown that yttrium(III) oxide modification by mixed adsorption layers of both polymers with different ionic character changes considerably the surface and stability properties of the examined solid suspensions.
Graphical Abstract
Export quality and wage premium
Authors: Guerra Francesco 
Published: November 2023

AbstractA growing body of research suggests a positive association between the quality of export products and income per capita, arguing that quality upgrades affect income through changes in the relative demand for skilled labor. This article falls within this literature and intends to shed light on the effect of quality upgrades of export products on average wages at the industry level. The study is conducted on the manufacturing sector over a set of 23 countries for which industry-level wage data are available. Contrary to previous studies which use unit values as an indirect measure of product quality, we rely on the methodology proposed in Khandelwal (Rev Econ Stud 77(4):1450–1476. https://doi.org/10.1111/j.1467-937X.2010.00602.x, 2010) and estimate quality as a residual of a demand equation. To establish a direct causal link between export quality upgrades and changes in wages, we use an instrumental variable strategy. Our results show that ahead of upgrades to export quality within a specific industry, average wages offered within the industry increase. In addition, we observe that the effect is larger for developing countries. Our findings imply that export product quality upgrades require more intensive use of qualified workers, who require higher wages.
The Flt3-inhibitor quizartinib augments apoptosis and promotes maladaptive remodeling after myocardial infarction in mice
Authors: Monogiou Belik Daria , Bernasconi Riccardo , Xu Lifen , Della Verde Giacomo , Lorenz Vera , Grüterich Vivienne , Balzarolo Melania , Mochizuki Michika , Pfister Otmar , Kuster Gabriela M. 
Published: November 2023

Abstract
Background
Tyrosine kinase inhibitors (TKIs) targeting fms-like tyrosine kinase 3 (Flt3) such as quizartinib were specifically designed for acute myeloid leukemia treatment, but also multi-targeting TKIs applied to solid tumor patients inhibit Flt3. Flt3 is expressed in the heart and its activation is cytoprotective in myocardial infarction (MI) in mice.

Objectives
We sought to test whether Flt3-targeting TKI treatment aggravates cardiac injury after MI.

Methods and results
Compared to vehicle, quizartinib (10 mg/kg/day, gavage) did not alter cardiac dimensions or function in healthy mice after four weeks of therapy. Pretreated mice were randomly assigned to MI or sham surgery while receiving quizartinib or vehicle for one more week. Quizartinib did not aggravate the decline in ejection fraction, but significantly enhanced ventricular dilatation one week after infarction. In addition, apoptotic cell death was significantly increased in the myocardium of quizartinib-treated compared to vehicle-treated mice. In vitro, quizartinib dose-dependently decreased cell viability in neonatal rat ventricular myocytes and in H9c2 cells, and increased apoptosis as assessed in the latter. Together with H2O2, quizartinib potentiated the phosphorylation of the pro-apoptotic mitogen activated protein kinase p38 and augmented H2O2-induced cell death and apoptosis beyond additive degree. Pretreatment with a p38 inhibitor abolished apoptosis under quizartinib and H2O2.

Conclusion
Quizartinib potentiates apoptosis and promotes maladaptive remodeling after MI in mice at least in part via a p38-dependent mechanism. These findings are consistent with the multi-hit hypothesis of cardiotoxicity and make cardiac monitoring in patients with ischemic heart disease under Flt3- or multi-targeting TKIs advisable.
Will climate affect the establishment and efficacy of Agnippe sp. #1 (Lepidoptera: Gelechiidae), a promising biological control agent of Mesquite in South Africa?
Authors: Cowie Blair W. , Heystek Fritz , Paterson Iain D. 
Published: November 2023

AbstractSeveral spiny leguminous tree species within the genus Neltuma Raf. (formerly Prosopis L.) (Fabaceae) occur as widespread invasive alien plants in South Africa, exerting severe negative socio-economic and ecological impacts. Given these impacts, South Africa recently released the leaf-tying moth Agnippe sp. #1 (syn. Evippe sp. #1) (Lepidoptera: Gelechiidae) as a biological control agent against invasive Neltuma species in 2021. The widespread invasion of Neltuma spp. across a vast and climatically diverse range of South Africa has led to concerns regarding the establishment and impact of the agent. Therefore, this study aimed to assess the constraints posed by climate to the potential establishment and efficacy of Agnippe sp. #1 using both climatic matching (CLIMEX) and thermal-physiology assessments. Climatic analyses revealed relatively high (71%) and moderate (66%) matches of South Africa to the native (Argentina) and introduced (Australia) ranges of Agnippe sp. #1 respectively. Thermal assessments of Agnippe sp. #1, particularly the 4th instar larvae, determined a CTmin = 0.9 ± 0.3 °C and LLT50 = −11.1 ± 0.4 °C, which suggest the moth is suited mainly to warmer regions of South Africa. Overall, these assessments propose that the establishment and performance of Agnippe sp. #1 is likely to be constrained by climate in parts of South Africa, particularly within the cold semi-arid and temperate provinces of the country. Promisingly, these climatic comparisons suggest that Agnippe sp. #1 may become more widely established in the hottest parts of the Northern Cape province, which remains a major biological control target region for Mesquite in South Africa.
Social presence and psychological distance: A construal level account for online distance learning
Authors: Weidlich Joshua , Yau Jane , Kreijns Karel 
Published: November 2023

AbstractOnline distance learning presents unique psychosocial characteristics due to the inherent distance between learners. Social presence –the sense of being with others– is key to mitigating this distance. However, our understanding of social presence remains limited, despite its potential to reduce social isolation and cultivate a conducive social space in online education. A gap in our understanding relates to how social presence aligns with more general accounts of interpersonal representations under conditions of psychological distance, as presented in Construal Level Theory. We conducted a vignette-based experiment (N = 194) to examine how psychological distance in online learning affects the mental construal level of a hypothetical partner and, thus, social presence perceptions. Findings suggest that increased psychological distance leads to higher-level construals, resulting in a perception of conversation partners as non-descript and homogenous. Importantly, this affects social presence perceptions, with certain nuances. These findings can inform novel approaches to enhance social presence in online learning.
Study on the driving factors and decoupling effect of carbon emission from pig farming in China—based on LMDI and Tapio model
Authors: Yang Bian , Wang Yufeng , Dunya Rahman , Yuan Xiangshang 
Published: November 2023

Abstract
The livestock sector accounts for 18% of total anthropogenic carbon emissions and is an important source of global greenhouse gas (GHG) emissions. China occupies a large proportion of total livestock carbon emissions worldwide, especially in the pig industry, which is significant to China's agricultural economy and also a key area for China to achieve the "Carbon peaking and Carbon neutrality goals." This study uses the life cycle approach to calculate the GHG emission status of China's pig farming industry from 2001 to 2020, and then, we establish a logarithmic mean Divisia index (LMDI) model to identify the main driving factors and a Tapio decoupling model to analyze its decoupling status. We decompose the emission sources as well as decoupling index into five drivers: technological progress, livestock structure, policy bias, affluence, and population. The results reveal that the carbon emission of China's pig industry is in a weak growth trend and overall in a weak decoupling state but has volatility, which is closely related to the "Pig Cycle" in China. Decomposition analysis shows that increasing affluence and population growth are the main drivers of GHG emissions; simultaneously, technological progress, livestock structure, and policy bias are the main drivers of emission reduction. Meanwhile, technological and policy factors positively contribute to the decoupling status, while affluence level, population, and livestock structure changes negatively inhibit the decoupling status. The study concludes that technological advances, optimized economic structures, the guidance of green consumption patterns, and the solution to the "Pig Cycle" problem are crucial to further reduce GHG emissions from China's pig industry; meanwhile, technological changes have a dominant role in promoting carbon decoupling in pig farming.
Veritistic Teleological Epistemology, the Bad Lot, and Epistemic Risk Consistency
Authors: Pils Raimund 
Published: November 2023

AbstractThis paper connects veritistic teleological epistemology, VTE, with the epistemological dimension of the scientific realism debate. VTE sees our epistemic activities as a tradeoff between believing truths and avoiding error. I argue that van Fraassen’s epistemology is not suited to give a justification for a crucial presupposition of his Bad Lot objection to inference to the best explanation (IBE), the presupposition that believing that p is linked to p being more likely to be true. This makes him vulnerable to a counterargument, tailored after Musgrave’s defense of IBE, which would result in a stalemate between them about presuppositions of rationality. I will, however, show that switching to VTE can justify van Fraassen’s presupposition. This leads to a dismissal of common IBE arguments for realism as presented by Boyd and Musgrave, but I also argue that a more cautious version of realism can be rescued from the Bad Lot objection. Finally, I raise some worries about epistemic risk-attitude consistency for constructive empiricists and develop an alternative anti-realist position.1
A Systematic Review of Attentional Bias in Problem Gambling
Authors: Farr Zoe , Broomfield Niall M. , Coventry Kenny R. 
Published: November 2023

AbstractA large body of previous research has provided support for the role of attentional bias as a maintaining factor in addiction. This systematic review aimed to investigate the extent and nature of attentional bias as a phenomenon which exists within problem gamblers. Studies were identified through searches of three databases (MedLine, PSYCHINFO, and Web of Science) and examination of the reference lists of the final studies meeting criteria for inclusion. The scope of the review included empirical studies making experimental comparisons of problem gamblers and non-problem gamblers across a range of attentional paradigms. A comparison of effect sizes was conducted across studies comparing problem to non-problem gamblers within and between attention paradigms. Twenty-two studies were reviewed systematically across ten experimental paradigms. Attentional bias was demonstrated in 16 of the 22 studies, with attentional bias effects varying across paradigms. Quality assessment revealed two main limitations across studies: lack of a priori power analysis, and failure to control for gambling frequency as a possible confounding variable. Findings support the role of attentional bias as a potential maintaining factor in problem gambling behaviour, in line with evidence for substance addiction. Recommendations for future studies are outlined alongside a discussion of clinical implications.
Characterization of anti-drug antibody dynamics using a bivariate mixed hidden-markov model by nonlinear-mixed effects approach
Authors: Brekkan Ari , Lledo-Garcia Rocío , Lacroix Brigitte , Jönsson Siv , Karlsson Mats O. , Plan Elodie L. 
Published: November 2023

AbstractBiological therapies may act as immunogenic triggers leading to the formation of anti-drug antibodies (ADAs). Population pharmacokinetic (PK) models can be used to characterize the relationship between ADA and drug disposition but often rely on the ADA bioassay results, which may not be sufficiently sensitive to inform on this characterization.In this work, a methodology that could help to further elucidate the underlying ADA production and impact on the drug disposition was explored. A mixed hidden-Markov model (MHMM) was developed to characterize the underlying (hidden) formation of ADA against the biologic, using certolizumab pegol (CZP), as a test drug. CZP is a PEGylated Fc free TNF-inhibitor used in the treatment of rheumatoid arthritis and other chronic inflammatory diseases.The bivariate MHMM used information from plasma drug concentrations and ADA measurements, from six clinical studies (n = 845), that were correlated through a bivariate Gaussian function to infer about two hidden states; production and no-production of ADA influencing PK. Estimation of inter-individual variability was not supported in this case. Parameters associated with the observed part of the model were reasonably well estimated while parameters associated with the hidden part were less precise. Individual state sequences obtained using a Viterbi algorithm suggested that the model was able to determine the start of ADA production for each individual, being a more assay-independent methodology than traditional population PK. The model serves as a basis for identification of covariates influencing the ADA formation, and thus has the potential to identify aspects that minimize its impact on PK and/or efficacy.