bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-chemotherapy Cardiotoxicity in Women With Breast Cancer
Authors: Maldonado-Vega Maria , Cejudo-Arteaga Shaila , Ramirez-Reyes Marco Antonio , Farias-Serratos Felipe , Teniente-Valente Raúl 
Published: October 2023

Abstract
Chemotherapy (CT) with anthracyclines can generate cardiotoxicity. The immunological system is part of the response to treatment with CT.
Objective. Women with breast cancer were evaluated during their CT treatment, assessing their response to cardiotoxicity according to the treatment regimens and the classification of the cancer.
Methods. Single CT and combined CT groups were made up (anthracyclines, Trastuzumab, and taxanes). Cardiotoxicity was measured as the Left Ventricle Expulsion Function (LVEF). The hematological response was measured at the end of treatment as the Lymphocyte/Macrophage Index (L/M) and the Lymphocyte/Platelet Index (L/P) The study included 451 women with breast cancer, among whom 230 underwent follow-up with LVEF on at least three occasions. Eight study groups were conformed based on their CT treatment. The comparison with LVEF was obtained between the baseline and the last LVEF.
Results. Combined CT diminished the LVEF, contrary to the CT of a single compound, which in addition showed a recovery from LVEF. The combined CT caused functional loss in terms of LVEF in 27% of the studied population. The L/MI increased, and the L/PI diminished in patients with the combined therapy. This suggests the participation of inflammation processes and vascular damage. Human epidermal growth factor receptor 2positive (HER2+) and triple- negative patients have less survival, above all when the LVEF baseline was <55%.
Conclusions. Anthracycline CT combined with other CT reduced the LVEF in women with breast cancer due to cardiotoxicity associated LVEF dysfunction. The use of only taxanes exerted a poor cardiotoxicity effect.
Nonlinear dynamic modeling and analysis of mesh stiffness of the spur gear pair considering tooth tip modification
Authors: Yang Hongbo , Yang Dongpo , Shi Wenku , Xu Miao 
Published: October 2023

Abstract
The mesh stiffness characteristics of the gear pair have direct effect on its transmission error, and then affect the noise and vibration level of the gear. To control the instability of gear meshing caused by tooth deformation, the tooth tip modification is an important mean, but it will undoubtedly introduce tooth profile errors. Firstly, considering the inconsistency between base circle and root circle under different tooth numbers, the potential energy method is improved to calculate the mesh stiffness of spur gear pair. Then, based on the theory of tooth tip modification and improved potential energy method, a new analytical method for mesh stiffness calculation considering tooth profile error is proposed. Taking a pair of spur gear as example, the finite element(FE) model is established, and the correctness of the proposed method is verified by comparing the time-varying mesh stiffness, mean stiffness, and peak-to-peak stiffness. The comparison results show that the method proposed in this paper can ensure high calculation accuracy while achieve lower computation cost. Finally, the sensitivity analysis is conducted on modification parameters including curve types, amount, and length. The influence of different parameters on mesh stiffness characteristics, bearing capacity, and noise problem is investigated.
Exploring the Impact of Visceral Fat and Subcutaneous Fat on Disease Severity and Outcome in Hospitalized Covid-19 Patients
Authors: Livani Somayeh , Alavi Elahe Sadat , Fatemi Alireza , Eshghinia Samira 
Published: October 2023

Abstract
Background
Obesity's connection to Covid-19 severity has prompted investigation into its impact on the immune system.
Purpose
This study explores the relationship between visceral and subcutaneous fat and disease outcomes in Covid-19 patients.
Methods
The study involved 318 hospitalized Covid-19 patients, including 161 women. Lung CT scans assessed lung involvement and measured visceral and subcutaneous fat levels. The ratio of visceral fat to subcutaneous fat was calculated. Patient files were reviewed for ICU hospitalization and mortality rates. SPSS16 software was used for data analysis.
Results
Age significantly influenced disease outcomes (p = 0.001). Men had higher mean visceral fat (117.55 ± 51.56), while women had higher mean subcutaneous fat (175.93 ± 79.79) (p < 0.001). The over-50 age group had significantly higher mean visceral fat (p = 0.021). Higher mean visceral and subcutaneous fat correlated with longer hospital stays (p < 0.05). However, no significant associations were found between fat measures, lung involvement severity, ICU hospitalization, or mortality (p > 0.05).
Conclusion
Age was significantly linked to disease severity and mortality in hospitalized Covid-19 patients. Visceral fat correlated with longer hospital stays, but not with lung involvement, ICU hospitalization, or mortality. High lung involvement was associated with greater subcutaneous fat, but not significantly. Subcutaneous fat levels were lower in ICU patients and had lower mortality rates, although not statistically significant.
Uncertainty inequality for weighted Fock spaces
Authors: Soltani Fethi 
Published: October 2023

Abstract

In this paper we introduce a weighted Fock space $\mathscr{F}_{\beta}$. This space which gives a generalization of some Hilbert spaces of analytic functions on the complex plane $\mathbb{C}$ like, the classical Fock space $\mathscr{F}$, the Dunkl type Fock space $\mathscr{F}_{\nu}$ and the Bessel-Struve type Fock space $\mathbb{F}_{\nu}$, it plays aback ground to our contribution. Especially, we study themultiplication operator $M$ by $z^2$ and its adjoint operator$L_{\mathscr{F}_{\beta}}$ on $\mathscr{F}_{\beta}$, and we deduce a general uncertainty inequality of Heisenberg type for this space.
2020 Mathematics Subject Classification: 30H20, 32A15
The association of glycemic control with patient survival and technique survival in incident diabetic peritoneal dialysis patients
Authors: Wang I-Kuan , Wang Tzu-Yuan , Yu Tung-Min , Yen Tzung-Hai , Yip Hei-Tung , Li Chi-Yuan , Lai Ping-Chin , Sung Fung-Chang 
Published: October 2023

Abstract

This study investigated the prognosis in incident diabetic peritoneal dialysis (PD) patients by glycemic control status. Compared to patients with time-averaged A1c values ≥9%, the risk of mortality was lower for patients with A1c of 6-6.9% [adjusted hazard ratio (HR) =0.39; 95% confidence interval (CI) =0.20, 0.78] and 7-7.9% (adjusted HR =0.47; 95% CI =0.24, 0.91). The risk of technique failure was lower for patients with time-averaged A1c of 6-6.9% (adjusted HR =0.55; 95% CI =0.33, 0.92) and 7-7.9% (adjusted HR =0.53; 95% CI =0.31, 0.90), compared to those with time-averaged A1c values ≥9%. Patients with baseline fasting serum glucose levels of 70-150 mg/dL had a lower risk of technique failure (adjusted HR =0.48; 95% CI =0.24, 0.97), compared to those with levels >300 mg/dL. Comparison based on time-averaged fasting serum glucose levels showed that patients with levels of of 70-150 mg/dL had a lower risk of mortality (adjusted HR =0.53; 95% CI =0.29, 0.99), compared to those with levels of 200-300 mg/dL. Diabetic PD patientswith time-averaged HbA1c 6-8% or fasting serum glucose levels of 70-150 mg/dL and time-averaged HbA1c 6-8% or baseline fasting serum glucose levels of 70-150 mg/dL had reduced risks of mortality and technique failure, respectively.
Outline for Empathy-Based Medical Education
Authors: Padmanabhan Vijayaraghavan 
Published: October 2023

Abstract
Empathy has been recognized in recent years to play a central role for the successful practice of medicine. Hence, developing empathetic skills needs to be the underlying objective during the training of undergraduate medical students as well as in continuous education of health professionals. However, during the process of medical education, the quality of empathy that is naturally present within the student has been found to decline. The task is to achieve the process of learning medicine and at the same time preserve and foster the quality of empathy. Spontaneous learning and action based on one’s own interest, is a form of self-directed learning that taps the student’s sense of curiosity about the problem and concern for the patient. Knowledge is acquired in a case-centred manner. All evaluations to be done through case-based discussions. The textbooks in each subject are to be treated as knowledge repositories for choosing the topics that need to be learnt. The ‘self-directed spontaneous learning’ ensures creativity in approach to problems, optimum utilization of one’s time and avoids stress. The student’s connection with his or her own ‘inner self’ is crucial for a focused and creative mind; therefore, its cultivation through the process of meditation is important. Empathy-based medical education-EBME facilitates the production of doctors who are competent as well empathetic.
Machining accuracy reliability optimization of three-axis CNC machine tools using doubly-weighted vector projection response surface method
Authors: Wang Zhiming , Lu Wenbin 
Published: October 2023

Abstract
The reasonable allocation of geometric errors of NC machine tools can improve the machining accuracy reliability. However, due to the complexity and high nonlinearity of limit state function (LSF) of machining accuracy reliability, the fitting accuracy is usually low when the traditional method is used to approximate LSF. To solve this problem, a doubly-weighted vector projection response surface (DWVPRS) method, which considers not only the approximation results of the test sample point to LSF but the distance between the test sample point and the most probable failure point (MPFP), is proposed. Using the reliability sensitivity analysis method, the key geometric errors were identified and optimized to meet the design requirements. Finally, taking a large gantry guideway grinding machine as an example to verifies the correctness and effectiveness of the DWVPRS method proposed in this paper, the results show that after the optimization of geometric accuracy, the minimum and average reliability value of the grinding machine meet the design requirements.
Can earthen plasters be effectively applied on different substrates?
Authors: Jia Quanquan , Chen Wenwu , Zhang Jingke , Tong Yanmei , Guo Qinglin 
Published: October 2023

Abstract
Earthen plasters have been widely used in historical buildings, especially in wall paintings in northwest China. However, the properties of earthen plasters have deteriorated dramatically under long-term weathering. In order to investigate one of the key issues in plaster restoration, i.e., whether the plaster can be effectively applied on different substrates, seven compositions of plasters were prepared and applied to three types of substrates modeled after actual wall painting supports. Shrinkage of the plasters was measured and the adhesion of the plasters to the substrates was characterized by a shear test using a designed device. The results show that the shrinkage of the plaster depends on the material composition of the plaster and is almost independent of the type of substrate. The addition of vegetal fibers to earthen plaster can effectively improve interfacial adhesion. The type and the surface roughness of the substrate have a significant effect on the adhesion between the earthen plaster and the substrate.
Antibody-conjugating nanogel (Conjugel) with two immune checkpoint inhibitors for enhanced cancer immunotherapy
Authors: Kim Jongseong , Park Yongdoo , Chae Yun Jin , Lee Kang-Gon , Oh Doogie , Lee Su-Kyoung 
Published: October 2023

Abstract
Cancer immunotherapy by immune checkpoint inhibitors (ICI) acts on antitumor responses by stimulating the immune system to attack cancer cells. However, this powerful therapy is hampered by its high treatment cost and limited efficacy. Here, we show the development of an antibody-conjugating system (Conjugel) that potentiates the efficacy of bispecific immunotherapy that simultaneously targets CTLA-4 and PD-L1. The Conjugel, consisting of highly deformable nanogels and antibody-binding protein, was loaded with two ICI monoclonal antibodies (mAb). Compared with mAb treatment alone, treatment with a bispecific Conjugel loaded with the both ICIs significantly decreased both the survival of MCF-7 and MDA-MB-231 breast cancer cells in vitro and the size of 4T1-Luc2-derived orthotopic syngeneic tumors in vivo. Furthermore, the ICI-loaded Conjugel was less toxic in vivo than the combination treatment delivered as a bolus. Our findings have important implications for Conjugel-based immunotherapy, developing the safer and higher efficacy of ICIs to treat breast cancers.
Synergistic use of anti-inflammatory ketorolac and gentamicin to target staphylococcal biofilms
Authors: Sekar Amita , Gil Dmitry , Tierney Peyton Anne , McCanne Madeline , Daesety Vikram , Trendafilova Darina , Muratoglu Orhun K , Oral Ebru 
Published: October 2023

Abstract
Background
While antibiotics remain our primary tools against microbial infection, increasing antibiotic resistance (inherent and acquired) is a major detriment to their efficacy. A practical approach to maintaining or reversing the efficacy of antibiotics is the use of other commonly used therapeutics, which show synergistic antibacterial action with antibiotics. Here, we investigated the extent of antibacterial synergy between the antibiotic gentamicin and the anti-inflammatory ketorolac regarding the dynamics of biofilm growth, the rate of acquired resistance, and the possible mechanism of synergy.
Methods
Control (ATCC 12600, ATCC 35984) and clinical strains (L1101, L1116) of S. aureus and S. epidermidis with varying antibiotic susceptibility profiles were used in this study to simulate implant-material associated low-risk and high-risk biofilms in vitro. The synergistic action of gentamicin sulfate (GS) and ketorolac tromethamine (KT), against planktonic staphylococcal strains were determined using the fractional inhibitory concentration measurement assay. Nascent (6hr) and established (24hr) biofilms were grown on 316 stainless steel plates and the synergistic biofilm eradication activity was determined and characterized using adherent bacteria count, MBEC measurement for GS, gene expression of biofilm-associated genes, visualization by live/dead imaging, scanning electron microscopy, and bacterial membrane fluidity assessment.
Results
Gentamicin-ketorolac combination demonstrated synergistic antibacterial action against planktonic Staphylococci. Control and clinical strains showed distinct biofilm growth dynamics and an increase in biofilm maturity was shown to confer further resistance to gentamicin for both ‘low-risk’ and ‘high-risk’ biofilms. The addition of ketorolac enhanced the antibiofilm activity of gentamicin against acquired resistance in staphylococcal biofilms. Mechanistic studies revealed that the synergistic action of gentamicin-ketorolac interferes with biofilm morphology and subverts bacterial stress response altering bacterial physiology, membrane dynamics, and biofilm properties.
Conclusion
The results of this study have a significant impact on the local administration of antibiotics and other therapeutic agents commonly used in the prevention and treatment of orthopaedic infections. Further, these results warrant the study of synergy for the concurrent or sequential administration of non-antibiotic drugs for antimicrobial effect.
Multi-innovation-based online variable projection algorithm for a class of nonlinear models
Authors: Su Jian-Nan , Su Xiang-Xiang , Chen Guang-Yong , Gan Min , Chen C. L. Philip 
Published: October 2023

Abstract

Separable nonlinear models (SNMs) are powerful tools for system identification, data analysis, and machine learning, thanks to their flexible structure and remarkable ability to capture nonlinear behaviors. However, compared with the offline one, the online identification of SNMs is more challenging, due to the dynamic nature of the nonlinear systems and the interdependence of the different parts of parameters in SNMs. Existing methods, such as the recursive Gauss-Newton (RGN) and recursive variable projection (RVP) methods, which cannot effectively handle the parameter interdependence, often suffer from slow convergence and poor performance in this scenario. In this paper, we propose a novel multi-innovation-based recursive variable projection (MIRVP) algorithm, which extends the RVP algorithm with a multi-innovation strategy. This strategy enables the algorithm to handle the interaction of the linear and nonlinear parameters more effectively, by using multiple past innovations instead of only the current one, thus improving the identification effect. We demonstrate the effectiveness of our MIRVP algorithm on both synthetic and real world datasets, showing its advantages in convergence speed and robustness over existing methods.
Quasi-Isomorphisms of Commutative DG Rings and Divided Power Structures
Authors: Yekutieli Amnon 
Published: October 2023

Abstract
We prove that a quasi-isomorphism f : A → B between commutative DGrings, where B admits a divided power structure, can be factored as f = f ̃ ◦ e, wheree : A → B ̃ is a split injective quasi-isomorphism, and f ̃ : B ̃ → B is a surjectivequasi-isomorphism.This result is used in our work on a DG approach to the cotangent complex, and ourwork on the derived category of commutative DG rings.
Study of Dispersion and Adsorption of Aerosols during Oral Practice
Authors: He junjie , Li Jiachun , Chen Bo , Yang Wei , Yu Xiaoyan , Zhang Fan , Li Yugang , Shu Haiyin , Zhu Xiankun 
Published: October 2023

Abstract
Objectives
In this study, we investigated the dispersion patterns of aerosols and droplets during oral practice, simulated the adsorption characteristics of suction devices, and evaluated the effectiveness of suction devices in reducing aerosols during dental procedures.
Materials and Methods
Firstly, the continuous images of oral aerosols and droplets were photographed with a high-speed camera, and the trajectories of these particles were recognized and processed by Image J to determine key parameters affecting particle dispersion: diffusion velocity, distance, and angle. Secondly, based on the parameters data, the flow field of aerosol particles around the oral cavity was simulated using computational fluid dynamics (CFD), and the flow field under adsorption conditions was simulated to demonstrate the aerodynamic characteristics and adsorption efficiencies of the single-channel and three-channel adsorption ports at different pressures. Finally, according to the simulated data, a three-channel suction device was developed, and the adsorption efficiency of the device was tested by the fluorescein tracer method.
Results
The dispersion experimental data showed that aerosol particles' maximum diffusion velocity, distance, and angle were 6.2 m/s, 0.55 m, and 130°, respectively. The simulated aerosol flow-field distribution was consistent with the aerosol dispersion patterns. The adsorption simulation results showed that the adsorption efficiency of the single-channel adsorption port could reach 74.05% at -350 pa, and the three-channel port was 99.23% at -350 pa and − 150 pa. The adsorption experimental data showed that the adsorption efficiency of three-channel suction device was 97.71%.
Conclusions
A three-channel suction device was designed by simulations and experiments, which can capture most aerosols in the dental clinic and prevent them from spreading.
Clinical relevance
Using three-channel suction devices during oral treatment effectively reduces the spread of oral aerosols, which is essential to prevent the spread of epidemics and ensure the health and safety of patients and dental staff.
A class of viscoelastic evolution equation on manifolds with conical singularities
Authors: Liao Menglan , Hajjej Zayd 
Published: October 2023

Abstract
In this paper, a class of viscoelastic evolution equation on manifolds with conical singularities is concerned. Local existence and uniqueness of the weak solution are established by making use of the Faedo-Galerkin method and the contraction mapping principle. Moreover, by constructing an auxiliary functional and exploiting Levine’s concavity method, the finite time blow-up criteria are obtained for arbitrary initial energy. In particular, the upper and lower bound of the blow-up time are also derived.
MSC(2020): 35R01; 35L20; 35B44.
Prevalence and Risk Factors of Dry Eye Disease in an Ophthalmological Center in Southern Brazil
Authors: Mahmud Islam Maruf Ahmad Maruf , Silva¹ Anaís Back , Abed³ Sabrina , Quinto¹ Guilherme G. , Morchbacher¹ Ricardo , Hazarbassanov² Rossen , Gomes² José Álvaro Pereira 
Published: October 2023

Abstract
Purpose: To determine the prevalence of Dry Eye Disease (DED) and its possible risk factors in the population of Rio Grande do Sul, Brazil.
Methods:A cross-sectional study was carried out through the patients who were referred to ophthalmic care at tertiary level. The patients were evaluated through the application of OSDI (Ocular Surface Disease Index) questionnaire. A specific questionnaire was created to register information on participants' demographics as well as risk factors associated, such as
age, gender, ethnicity, education, medications, systemic diseases, eye disease, contact lenses, daily screen time, physical exercise, smoking, pregnancy, previous ocular surgery.
Results: A total of 300 individuals participated in this study [mean (SD) age 62.71 (15.04) years, range 12-93 years; 64,33% females]. The prevalence of syntomatic dry eye was 53.65% (mean OSDI score of 21.01): 36.66% had mild dry eye, 13,66% moderate and 3.66% severe symptoms. There was a significant positive association between symptomatic dry eye and smoking [95% CI (1.100 – 1.708); p<0.05], which means that smoking increased the risk of dry eye (mild, moderate or severe) by 37%. The other risk factors did not show a statistically significant correlation with the development of dry eye disease.
Conclusion: This study demonstrated a high prevalence of DED in patients seeking tertiary ophthalmological care in Southern Brazil. This represents a high proportion of the population with DED and a significant public health problem that requires attention from public authorities. Regarding the risk factors associated, only smoking increased the risk of developing the dry eye.
Galois cohomology of SO(N)-connections
Authors: Saito Cyprien 
Published: October 2023

Abstract
Two different types of Fuchsian function of the second kind are possible for SU(2)-bundle on U(1)-flat-connections of Chern-Simons field. Both of two different types of Fuchsian are parametrized by the same moduli as the LF-invariant measure situated on arbitrary Galois cohomology. One is characterized by polylogarithmic functions and the other is by the immanent monodromy preserving deformations within the similar preparatory polylogarithmic conditioning. After the comparaison between the Fuchsians, it will be known that the categorical commutativity of modules fixed by a certain Galois cohomology works for the regulator of the formality of Galois cohomology existing arbitrarily in common for two Fuchsians and there exists closed oriented 3-manifolds as the invariance for SO(N)-connections fixed by arbitrary Galois cohomology for one SO(N)-connection and parametrized by Chern-Simons field.