bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of hereditary angioedema in resource-constrained settings: A consensus statement from Indian subcontinent
Authors: Jindal Ankur Kumar , Sil Archan , Aggarwal Ridhima , Vinay Keshavamurthy , Bishnoi Anuradha , Suri Deepti , Rawat Amit , Kumaran Muthu Sendhil , Saikia Biman , Sarkar Rashmi , Gupta Lalit , Kumar D Dinesh , Jindal Rashmi , Sukumaran T U , Ouseph Jose , Longhurst Hilary , Pawankar Ruby , Singh Surjit , Dogra Sunil 
Published: February 2024

Hereditary angioedema (HAE) is an uncommon disorder characterized clinically by recurrent episodes of nonitchy subcutaneous and/or submucosal swellings. The estimated prevalence of HAE is ~ 1: 10,000 to 1: 50,000. There are no prevalence data from India, however, estimates suggest that there are 27,000 to 135,000 patients with HAE in India at present. The majority of these, however, remain undiagnosed.
Replacement of plasma-derived or recombinant C1-esterase inhibitor (C1-INH) protein, administered intravenously, is the treatment of choice during the management of acute episodes of angioedema (i.e., “on-demand treatment”) and is also useful for short-term prophylaxis (STP) and long-term prophylaxis (LTP). This has been found to be effective and safe even in young children and during pregnancy.
Until recently, none of the first-line treatment options were available for “on-demand treatment,” STP or LTP in India. As a result, physicians had to use fresh frozen plasma for both “on-demand treatment” and STP. For LTP, attenuated androgens (danazol or stanozolol) and/or tranexamic acid were commonly used. These drugs have been reported to be useful for LTP but are associated with a significant risk of adverse effects.
Intravenous pd-C1-INH, the first-line treatment option, is now available in India. However, because there is no universal health insurance, access to pd-C1-INH is a significant challenge.
HAE Society of India has developed these consensus guidelines for India and other resource-constrained settings where plasma-derived C1-INH therapy is the only available first-line treatment option for the management of HAE and diagnostic facilities are limited. These guidelines have been developed because it may not be possible for all patients to access the recommended therapy and at the recommended doses as suggested by the international guidelines. Moreover, it may not be feasible to follow the evaluation algorithm suggested by the international guidelines.
Optimal period for achieving sustained unresponsiveness in peanut oral immunotherapy
Authors: Yamashita Kosei , Nakamura Toshinori , Imai Takanori , Honda Aiko , Okada Yuki , Maeda Mayu , Kamiya Taro 
Published: February 2024

Background:
Oral immunotherapy (OIT) can help children with persistent food allergies achieve sustained unresponsiveness (SU). However, the optimal therapeutic period for obtaining SU remains unclear.

Objective:
We aimed to retrospectively investigate the association between the OIT treatment period and achievement of SU.

Methods:
We enrolled patients who received OIT for peanut allergy between January 1, 2018 and December 31, 2022. OIT comprised the build-up phase, maintenance phase, complete avoidance, and an oral food challenge (OFC) for confirming SU. The peanut dose in the OFC was gradually increased to 3,000 mg (peanut protein: 795 mg), which was subsequently maintained for ≥5 months. SU was defined as a negative response to 795 mg of peanut protein after ≥2 weeks of complete avoidance. We evaluated the therapeutic OIT period for achieving SU using Kaplan–Meier analysis.

Results:
Forty-eight patients underwent peanut OIT. The starting age at OIT initiation was 8 (interquartile range [IQR], 7–10) years. Forty-one (85%) patients had a history of anaphylaxis. The median specific immunoglobulin E concentration to peanut and Ara h 2 at OIT initiation was 85.3 (IQR, 33.7–100) and 57.6 (IQR, 21.9–100) UA/mL, respectively. The median observational period was 2.1 (IQR, 1.6–3.0) person-years (PY). Thirty-four (71%) patients achieved SU, with the rate of SU achievement gradually increasing with the therapeutic period. The median period until SU achievement was 2.1 (95% confidence interval, 1.6–2.5) PY. The rate of SU achievement slowed down after 2.7 PY.

Conclusion:
OIT for at least 2.7 PY can increase the rate of SU achievement. The protocol No. 3107.
APAAACI clinical pathway on direct provocation testing for penicillin allergy delabeling
Authors: Li Philip Hei , Thong Bernard Yu-Hor , Pawankar Ruby , Jeewandara Chandima , Lobo Rommel Crisenio M. , Kang Hye-Ryun , Mahesh Padukudru Anand , Meng Juan , Munkhbayarlakh Sonomjamts , Pham Duy Le , Rerkpattanapipat Ticha , Tang Min-Moon , Yamaguchi Masao , Abdul Latiff Amir Hamzah , Rengganis Iris , Wang Jiu-Yao , Zhang Luo , Lucas Michaela 
Published: February 2024

Background:
Allergy to penicillin is commonly reported in many countries and is an overwhelming global public health concern. Penicillin allergy labels can lead to the use of less effective antibiotics and can be associated with antimicrobial resistance. Appropriate assessment of suspected penicillin allergy (often including skin testing, followed by drug provocation testing [DPT] performed by allergists) can prevent the unnecessary restriction of penicillin or delabelling. Many countries in the Asia Pacific (AP) have very limited access to allergy services, and there are significant disparities in the methods of evaluating penicillin allergy. Therefore, a clinical pathway for the management of penicillin allergy is essential.

Objectives:
To develop a risk-stratified clinical pathway for delabeling penicillin allergy, taking into account the distinct epidemiology, patient/sensitization profiles, and disparities of allergy services or facilities within the AP.

Methods:
A risk-stratified penicillin allergy delabeling clinical pathway was formulated by the Drug Allergy Committee of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology. and members of the Penicillin Allergy Disparities survey in AP each representing one country/region of the AP. The clinical pathway was tested based on a database of anonymized patients who were sequentially referred for and completed penicillin allergy evaluation in Hong Kong.

Results:
The clinical pathway was piloted employing a “hub-and-spoke” approach to foster multidisciplinary collaboration between allergists and nonallergists. A simulation run of the algorithm on a retrospective Hong Kong cohort of 439 patients was performed. Overall, 367 (84%) of patients were suitable for direct DPT and reduced the need for skin testing or specialist’s care for 357 (97%) skin test-negative individuals. Out of the skin test-negative patients, 345 (94%) patients had a negative DPT.

Conclusions:
This risk-stratification strategy for direct oral DPT can reduce the need for unnecessary skin testing in patients with low-risk penicillin allergy histories. The hub and spoke model of care may be considered for further piloting and validation in other AP populations that lack adequately trained allergists.
Association of Socioeconomic Status With Worse Overall Survival in Patients With Bone and Joint Cancer
Authors: Mani Kyle , Kleinbart Emily , Schlumprecht Anne , Golding Regina , Akioyamen Noel , Song Hyun , De La Garza Ramos Rafael , Eleswarapu Ananth , Yang Rui , Geller David , Hoang Bang , Fourman Mitchell S. 
Published: February 2024

Background:
The effect of socioeconomic status (SES) on the outcomes of patients with metastatic cancer to bone has not been adequately studied. We analyzed the association between the Yost Index, a composite geocoded SES score, and overall survival among patients who underwent nonprimary surgical resection for bone metastases.

Methods:
This population-based study used data from the National Cancer Institute's Surveillance, Epidemiology, and End Results database (2010 to 2018). We categorized bone and joint sites using International Classification of Disease-O-3 recodes. The Yost Index was geocoded using a factor analysis and categorized into quintiles using census tract–level American Community Service 5-year estimates and seven measures: median household income, median house value, median rent, percent below 150% of the poverty line, education index, percent working class, and percent unemployed. Multivariate Cox regression models were used to calculate adjusted hazard ratios of overall survival and 95% confidence intervals.

Results:
A total of 138,158 patients were included. Patients with the lowest SES had 34% higher risk of mortality compared with those with the highest SES (adjusted hazard ratio of 1.34, 95% confidence interval: 1.32 to 1.37, P < 0.001). Among patients who underwent nonprimary surgery of the distant bone tumor (n = 11,984), the age-adjusted mortality rate was 31.3% higher in the lowest SES patients compared with the highest SES patients (9.9 versus 6.8 per 100,000, P < 0.001). Patients in the lowest SES group showed more racial heterogeneity (63.0% White, 33.5% Black, 3.1% AAPI) compared with the highest SES group (83.9% White, 4.0% Black, 11.8% AAPI, P < 0.001). Higher SES patients are more likely to be married (77.5% versus 59.0%, P < 0.0001) and to live in metropolitan areas (99.6% versus 73.6%, P < 0.0001) compared with lower SES patients.

Discussion:
Our results may have implications for developing interventions to improve access and quality of care for patients from lower SES backgrounds, ultimately reducing disparities in orthopaedic surgery.
Energy Consumption and Substrate Utilization During Spinal Surgery
Authors: Zonshayn Samuel , Coppola Christina , Lawrence James P. 
Published: February 2024

Introduction:
This study aims to measure surgeon physiologic stress and energy expenditure during adult spine surgery. Energy expenditures were assessed based on patient BMI, lead use, instrumentation/intraoperative navigation, primary/revision surgeries, tranexamic acid (TXA) use, and anatomic region involved.

Methods:
The senior author wore a heart rate (HR) monitor and triaxial accelerometer during spinal surgeries, providing assessments of mean HR, maximum HR, calories consumed/minute, and calories as measured by a Polar device (P calories) and Fitbit device (F calories).

Results:
One hundred sixty-two surgeries were included. Median patient age was 62 years. Median BMI was 29.02. Significant differences existed for BMI and estimated blood loss (P < 0.05). TXA use had a significant effect on case time, estimated blood loss, P calories, F calories, and Kcal/min (P < 0.05). Instrumentation use was significant for all variables (P < 0.05), except for mean HR and Kcal/min (P > 0.05). Lead use did not have a significant effect on max HR, P calories, F calories, and Kcal/min (P > 0.05). Navigation use was associated with significant differences for every variable tested (P ≤ 0.05). Differences were observed between primary and revision surgeries for case time, estimated blood loss, and F calories (P < 0.05).

Conclusions:
In spinal surgery, the use of navigation, instrumentation use, TXA use, and performing revision surgeries were associated with increased energy expenditure and can potentially increase surgeon fatigue.
Peran Gereja dalam Membentuk Karakter Remaja Kristen di Era Kontemporer
Authors: Gea Erniwati , Waruwu Anwar Three Millenium , Novalina Martina , Rohy Ampinia Rahap Wanyi 
Published: February 2024

The education of adolescent character plays a significant role in shaping a future generation that is robust and responsible. In this contemporary era, replete with various challenges, sturdy character and strong moral values stand as essential foundations required by Christian adolescents. The church assumes a strategic role in ensuring the balanced and ethical development of adolescent character. This research aims to analyze the church's contribution as an effective partner for parents in molding adolescent character, as well as how character education within the church can cater to the individual needs of each adolescent in the contemporary era. The methodology employed in this study is a literature review, involving the extraction of information from diverse literary sources such as books, documents, magazines, journals, and newspaper publications. The research findings indicate that the roles of the church, family, and community are paramount in providing support, education, and guidance to Christian adolescents in facing challenges like technological influence and negative temptations. Collaboration between the church, family, school, and relevant institutions emerges as the linchpin in shaping the character of Christian adolescents. Through a pertinent and inclusive approach, Christian adolescents can grow in faith and become stalwart successors for the nation and the church in the future. Abstrak:Pendidikan karakter remaja memegang peran penting dalam membentuk generasi masa depan yang kuat dan bertanggung jawab. Di era kontemporer yang penuh dengan berbagai tantangan, karakter yang kokoh dan nilai-nilai moral yang kuat adalah fondasi utama yang dibutuhkan oleh remaja Kristen. Gereja memiliki peran strategis dalam memastikan pertumbuhan karakter remaja yang seimbang dan beretika. Penelitian ini bertujuan untuk menganalisis kontribusi gereja sebagai mitra efektif bagi orang tua dalam membentuk karakter remaja, serta bagaimana pendidikan karakter di gereja dapat memenuhi kebutuhan individu masing-masing remaja di era kontemporer. Metode kajian pustaka digunakan dalam penelitian ini, dengan menggali informasi dari berbagai sumber literatur seperti buku, dokumen, majalah, jurnal, dan publikasi surat kabar. Hasil penelitian menunjukkan bahwa peran gereja, keluarga, dan komunitas sangat vital dalam memberikan dukungan, pendidikan, dan bimbingan kepada remaja Kristen dalam menghadapi tantangan-tantangan seperti pengaruh teknologi dan godaan-godaan negatif. Kerjasama antara gereja, keluarga, sekolah, dan lembaga terkait menjadi kunci dalam membentuk karakter remaja Kristen. Dengan pendekatan yang relevan dan inklusif, remaja Kristen dapat tumbuh dalam iman dan menjadi penerus yang kuat bagi bangsa dan gereja di masa depan.Kata Kunci: Pendidikan Karakter, Remaja Kristen, Peran Gereja, Era Kontemporer.
Studi Hermeneutik Feminis Terhadap Kisah Abigail dan Implikasinya bagi Ibu Rumah Tangga
Authors: Rosnaminarti Rosnaminarti , Putri Eltin Srikarni , Algita Nansi 
Published: February 2024

This article aims to change perspectives on the role and position of a housewife. The author examines this problem related to subordination and discrimination against housewives. The author chose the story of Abigail in 1 Samuel 25:2-44 as study material. The author uses a hermeneutic-feminist approach from Elizabeth Schussler Fiorenza. The author found that Abigail became reflective material for encouraging equality between men and women by involving women in decision making and participating in public spaces. However, the church must also empower men and women through equal access to education. The author hopes that this article can encourage the church to emphasize complete equality between men and women, starting from education, freedom of opinion, and participation in public spaces.Abstrak:Masalah dalam artikel ini adalah subordinasi dan diskriminasi yang terjadi kepada ibu rumah tangga. Oleh karena itu, artikel ini bertujuan untuk mengubah perspektif terhadap peran dan kedudukan seorang ibu rumah tangga. Peneliti memilih kisah Abigail dalam 1 Samuel 25:2-44 sebagai bahan kajian. Peneliti menggunakan pendekatan hermeneutik-feminis dari Elizabeth Schussler Fiorenza. Peneliti menemukan bahwa Abigail menjadi bahan reflektif untuk mendorong kesetaraan laki-laki dan perempuan, memberikan ruang kebebasan bagi perempuan untuk berpendapat, melepaskan istri dari kekangan suaminya, serta memberi ruang jika sewaktu-waktu hendak berpartisipasi di ruang publik. Peneliti berharap tulisan ini dapat mendorong gereja menekankan kesetaraan yang utuh antara laki-laki dan perempuan.. Kata Kunci: 1 Samuel 25, Abigail, hermeneutik feminis, ibu rumah tangga
The importance of individual characteristics on bicycle performance during alcohol intoxication
Authors: Andersérs Caroline , Andersson Jan , Wallén Warner Henriette 
Published: February 2024

Bicycling accidents are a well-known problem for traffic safety globally. Alcohol intoxication is one possible factor, although the exact number of accidents due to intoxication is difficult to establish. Not all bicyclists act in the same way, particularly when under the influence of alcohol, i.e. bicycling performance might be related to a bicyclist's personal characteristics. This study aimed to investigate if the bicyclist's characteristics (bicycling experience, physical fitness, or sensation seeking scores) influence bicycling stability, cognitive performance, or self-rated bicycling ability ratings at different levels of alcohol intoxication. The experiment was completed on a wide treadmill, which allowed control of several influencing factors such as speed and physical effort. Intoxicated and sober participants bicycled on the treadmill five times for 10 minutes each time, and breath alcohol concentration (BrAC) levels were measured five times. Participants were given doses of alcohol up to a BrAC level of 0.8‰. The results revealed that alcohol intoxication had a significant effect on stability, cognitive executive functions, and self-rated ability to bicycle on the treadmill. Group characteristics had an effect on bicycling performance and on self-ratings of bicycling ability when intoxicated. Alcohol intoxication affects stability, cognitive performance, and perceived ability to bicycle. Group characteristics are important for examining possible self-regulated behavior, as some groups rate that they can bicycle safely, even when there is an objective decrease in stability and executive functions.
Study of Magnetic Susceptibility of Ge4+ Doped Cu-Zn Ferrite
Authors: Padampalle Ashok S. 
Published: February 2024

Polycrystalline spinel ferrite Cu_(0.7+x) Zn_0.3 Ge_x Fe_(2-2x) O_4 where x= 0.0, 0.1 to 0.6 prepared by standard double sintered ceramic method. The a. c. susceptibility measurements on powdered samples were made using double coil set up. A specimen is kept in the center of a balanced double coil which itself is at the center of a Helmholtz coil system producing an alternating magnetic field behaves like an alternating dipole and induces a differential emf in the double coil. cT/cRT does not vary with temperature. As composition of Ge4+ is increased the Curie temperature (Tc) decreases. Near the Curie temperature there is sharp decrease of cT/cRT suggesting the single-phase formation of material.
RESILIENCE OF FARMERS ON THE SUSTAINABILITY OF NATURAL FARMING SYSTEMS FOR UPLAND RICE IN MOROTAI ISLAND
Authors: Rope Ranita , Marengke Musa , Mulyo Jangkung Handoyo , Waluyati Lestari Rahayu , Masyhuri  , Perwitasari Hani 
Published: February 2024

Objective: Sustainable agricultural development necessitates that every region of the world discovers or develops farming practices and systems suited to the local environment. Additionally, initiators encourage the adoption and spread of more sustainable agriculture methods. This study aimed to determine: 1) the resilience of farmers concerning the principles of natural farming methods for upland rice to the level of economic sustainability, 2) the resilience of farmers concerning the principles of natural farming systems for upland rice to the level of socio-cultural sustainability, 3) the resilience of farmers concerning the principles of natural farming systems for upland rice to the level of environmental sustainability, 4) the willingness of farmers to retain the economic viability of the natural farming system of upland rice, 5) the willingness of farmers to retain the environmental viability of the natural farming system of upland rice, and 6) the willingness of farmers to preserve the socio-cultural sustainability of the natural farming system of upland rice.

Method: This research was conducted on Morotai Island, North Maluku Province. The selection of this region was purposive, while the selection of farmers as sample respondents was determined by random sampling. Data were analyzed using Structural Equation Modeling (SEM) and LISREL 8.70.

Results: According to the research findings, farmers' perceptions of natural farming systems are a determining factor in farmer resilience. This factor has a positive impact on the sustainability of socio-cultural and environmental aspects but does not affect the sustainability of the economic component. Meanwhile, the willingness to maintain natural farming systems is a resilience element for farmers that influences the sustainability of economic and socio-cultural dimensions but not the environmental component. This study concludes that farmer resilience to the principles of natural upland rice farming systems in the border region of Morotai Island has distinct characteristics and is an economically, socio-culturally, and environmentally sustainable agricultural system.

Conclusion: This study concludes that the resilience of farmers to the principles of natural upland rice farming systems in the border region of Morotai Island has a distinctive character and is an economically, socioculturally, and environmentally sustainable agricultural system.
SUSTAINABILITY OF CULTURAL VALUES, INHERITANCE, AND LITERACY IN STRENGTHENING HUMAN RESOURCES IN MINANGKABAU
Authors: Efrizon  , Mz Masyhudzulhak Djamil , Santoso Sugeng , Saluy Ahmad Badawi 
Published: February 2024

Objective: To obtain an overview of the reality of the concept and construction of original cultural values in the lives of the Minangkabau indigenous people in Tiga Luhak, and their integration into sustainable development and strengthening of human resources.

Methods: This research uses a qualitative approach with an ethnographic method based on the Post-Positivism paradigm of Interpretive Phenomenology, a holistic study, searching for the essence, and implicating moral values in observation, analysis and making conclusions regarding the disclosure of social facts of the Minangkabau indigenous people.

Results: In line with the global issue of sustainability in the Sustainable Development Goals program where the mandate is to preserve the Culture of Indigenous Peoples and Indigenous Peoples of an area, this research becomes important when changes have impacted shifting indigenous cultural values in indigenous peoples. The construction of indigenous knowledge and Minangkabau cultural values has been used and developed for a long time in the social structure of their society. Minangkabau custom contains values and knowledge, something that is original and inherent as a worldview and outlook on life. Minangkabau's original cultural values and knowledge are inherited and become clothing in the daily order of indigenous peoples. The concept of Surau and Silek became the starting point for the development of science. It became the center for studying an in-depth understanding of the natural surroundings which has inherited the wisdom, reason and local wisdom of the Minangkabau people. Minangkabau indigenous cultural values and knowledge have become social and intellectual capital in developing and strengthening human resources.

Conclusions: Minangkabau customs and culture are a construction of a series of values, beliefs, knowledge, local wisdom and collective agreements based on the concept of Minangkabau scientific studies, namely epistemology which departs from an understanding of the philosophy of Alam Takambang Jadi Guru. Traditional and cultural values are the foundation in the construction of knowledge in Minangkabau, and these values are the guidelines and way of life for the community. Minangkabau cultural values and indigenous knowledge which have been the basis for the Minang people's life goal.