bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trend Analysis of Extreme Wind and Wave Height at Key Port Locations along the Indian Coastline
Authors: Prasad Ramakant , Kumar Prashant , Singh Anurag , Kumar Avinash , . Rajni 
Published: January 2024

Abstract

Long-term trends of wind speed (WS) and significant wave height (SWH) in the Arabian Sea (AS) and Bay of Bengal (BoB) are of great interest to scientists, engineers, climate modelers, and policymakers. It is associated with global climate change and efficient offshore and near-shore socio-economic activity management. In this study, the climatology and variability of mean and extreme SWH and WS is determined during the monsoon (JJA) and post-monsoon (SON) seasons along the Indian coastline during 1979--2021 using ERA5 reanalysis datasets. The generalized extreme value (GEV) distribution is utilized to determine the extreme values of SWH and WS. Further, linear trend analysis is also carried out at six key port locations (Paradip, Visakhapatnam, Chennai, Mumbai, Mangalore, and Kochi) along the Indian coastline. The outcome reveals that mean SWH displays an increasing trend (Paradip, Visakhapatnam, Chennai, Mumbai, Mangalore, and Kochi) during JJA and SON seasons while mean WS shows a decreasing trend in JJA season and an increasing trend in SON season. The maximum rate of increase in extreme SWH is observed at Kochi (r=0.78 cm yr-1) and Paradip port (1.32 cm yr-1) during JJA and SON seasons, respectively. In SON season, extreme WS exhibits an increasing trend at all six locations, and the rate of increase is maximum at Visakhapatnam (3.46 cm s-1 yr-1), followed by Paradip (3.39 cm s-1 yr-1) and minimum at Mumbai (1.84 cm s-1 yr-1). Kochi and Paradip ports experienced a significant increase in extreme SWH and WS during JJA and SON seasons, respectively.
Multilayer Ferromagnetic Spintronic Devices for
Neuromorphic Computing Applications
Authors: Lone Aijaz H. , Zou Xuecui , Mishra Kishan K. , Singaravelu Venkatesh , Sbiaa Rachid , Fariborzi Hossein , Setti Gianluca 
Published: January 2024

Abstract

Spintronics has made substantial progress due to its applications in energy-efficient
memory, logic, and unconventional computing paradigms. Multilayer ferromagnetic
thin films are extensively studied for understanding the domain wall and skyrmion
dynamics. However, most of these studies are confined to the materials and domain
wall/skyrmion physics. This paper presents the experimental and micromagnetic realization
of a multilayer ferromagnetic spintronic device for neuromorphic computing
applications. The device exhibits multilevel resistance states, and the number of resistance
states increases with a lower temperature. This is supported by the multilevel
magnetization behavior observed in the micromagnetic simulations. Furthermore, we
also do experiments and simulations to realize current-driven multi-step resistance
states. Using the multi-level resistance states of the device, we propose its applications
as a synaptic device in hardware neural networks and study the linearity performance
of the synaptic devices. The neural network based on these devices is trained and
tested on the MNIST dataset using a supervised learning algorithm. When integrated
as a weight into a 3-layer, fully connected neural network, these devices achieve above
90% recognition accuracy on the MNIST dataset.
Radiomic model of contrast-enhanced computed tomographyfor predicting liver injury in acute pancreatitis patients
Authors: Liu Lu , Yu Ningjun , Liu Tingting , Chen Shujun , Pu Yu , Tang Wei , Li Yong , Zhang Xiaoming , Li Xinghui 
Published: January 2024

Abstract
Objectives
To predict liver injury in acute pancreatitis (AP) patients by establishing a radiomics model based on contrast-enhanced computed tomography (CECT).
Methods
A total of 1223 radiomic features were extracted from late arterial-phase pancreatic CECT images of 209 AP patients (146 in the training cohort and 63 in the test cohort), and the optimal radiomic features retained after dimensionality reduction by least absolute shrinkage and selection operator (LASSO) were used to construct a radiomic model through logistic regression analysis. In addition, clinical features were collected to develop a clinical model, and a joint model was established by combining the best radiomic features and clinical features to evaluate the practicality and application value of the radiomic models, clinical model and combined model.
Results
Four potential features were selected from the pancreatic parenchyma to construct the radiomic model, and the area under the receiver operating characteristic curve (AUC) of the radiomic model was significantly greater than that of the clinical model for both the training cohort (0.993 vs. 0.653, p = 0.000) and test cohort (0.910 vs. 0.574, p = 0.000). The joint model had a greater AUC than the radiomics model for both the training cohort (0.997 vs. 0.993, p = 0.357) and test cohort (0.925 vs. 0.910, p = 0.302).
Conclusions
The radiomic model based on CECT has good performance in predicting liver injury in AP patients and can guide clinical decision-making and improve the prognosis of patients with AP.
Efficacy and Safety of Low Dose Rivaroxaban in High Ischemic Risk Patients with Chronic Coronary Syndrome: Rationale and Design of the Dutch CCS Registry
Authors: Selvarajah A. , Heijden D. J. van der , Remkes W. S. , Berg J. M. ten , Magro M. , von Birgelen C. , Riezebos R. K. , Pisters R. , Hemels M. , Rasoul S. , Hof A. W.J. van 't , Somi S. , Polad J. , Hoogslag P. , Hermanides R. S. 
Published: January 2024

Abstract

Background Despite advancements in secondary cardiovascular prevention, individuals with chronic coronary syndrome (CCS) still experience a lingering risk of adverse ischemic events. To minimize this residual risk by stabilizing and regressing the chronic disease process, there is consensus that antithrombotic therapy is crucial role for secondary cardiovascular prevention. The combination of low-dose rivaroxaban (2.5mg BID) with aspirin, known as dual-pathway inhibition, has emerged as a strategy to mitigate this residual risk and lower major adverse cardiovascular events (MACE). European guidelines, based on findings of the COMPASS trial, recommend incorporating low-dose rivaroxaban and aspirin into standard secondary prevention in CCS patients. However, real-world data on the impact of this approach are still lacking. Aim The primary objective of the DUTCH-CCS registry is to gather real-world data on the efficacy and safety of low-dose rivaroxaban in combination with aspirin among patients with CCS in the Netherlands. By conducting this registry, the aim is to bridge the gap in knowledge and provide insights into the practical outcomes and potential benefits or risks associated with the use of dual-pathway inhibition in a real-world clinical setting, beyond the confines of controlled clinical trials. Methods The DUTCH-CCS registry is a national, multicenter, prospective observational study, and aims to enroll 1000 adult CCS patients who are treated with rivaroxaban 2.5mg BID plus aspirin. The study focuses on high ischemic risk individuals with coronary artery disease (CAD) and/or peripheral artery disease, using a single-arm design. The primary effectiveness endpoint includes major adverse cardiac events (MACE), clinically driven coronary-, peripheral- or carotid revascularization, and stent thrombosis at 1-year follow-up, while the primary safety endpoint is major bleeding at 1-year. The study will collect outcome data at 3-month and 1-year follow-up. Conclusion The DUTCH-CCS registry holds the potential to enhance understanding of the real-world impact of low-dose rivaroxaban plus aspirin as a secondary prevention strategy in CCS patients. The findings may offer valuable insights into the efficacy and safety of dual-pathway inhibition, providing clinicians and researchers with data for informed treatment decisions and may refine guidelines for the management of CCS patients in everyday clinical practice. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT04753372
Graphene Quantum Dots interacting with Nipah Virus: a Docking and Dynamic Molecular analysis
Authors: AROUCHE TIAGO , Almeida Aguinaldo Pantoja , Neto Antonio Maia de Jesus Chaves 
Published: January 2024

Abstract

This comprehensive examination, encompassing a variation in size among the structures, aimed to elucidate the influence of size on molecular interaction dynamics through rigorous anchoring and molecular dynamics simulations. Our investigation delineated a predominant presence of hydrophobic interactions proximate to the receptor binding sites within the complexes. Notably, the affinity energy values of the ligands exhibited a direct correlation with the overall stability of the formed complexes. Concurrently, the Root Mean Square Deviation (RMSD) values of these complexes served as a reliable indicator of their stability dynamics. Consequently, our outcomes propose the potential of protein conjugation with quantum dots in enhancing the adsorption capacity for viral protein components. Moreover, our scrutiny delved deeper into the specific interactions between the Nipah virus macrostructure and quantum dots QD-K, QD-G, and QD-F, revealing robust and enduring bonds. Docking studies unveiled affinity energy scores of -13.658 kcal/mol, -13.6 kcal/mol, and − 13.9 kcal/mol, respectively, for these three ligands. Further corroborating these findings, Gibbs free energy analysis produced consistent outcomes, attributing values of 239.00 kcal/mol, 246.65 kcal/mol, and 259.52 kcal/mol to QD-F, QD-G, and QD-K, respectively. These compelling insights accentuate QD-K, QD-G, and QD-F as promising candidates for potential therapeutic interventions targeting the Nipah virus, indicative of their robust binding affinity and considerable stability within the studied complexes.
Integrated transcriptomic and metabolomic analysis provides insights into cold tolerance in lettuce (Lactuca sativa L.)
Authors: Yang Xiao , Han Yingying , Huo Guotao , Ge Guojun , He Shuping , Yang Xiao , Zhang Li , Wei Shiwei , Luo Lijun 
Published: January 2024

Abstract
The popular leafy vegetable lettuce (Lactuca sativa L.) is susceptible to cold stress during the growing season, which slows growth rate, causes yellowing and necrosis of the leaves and lowers yield and quality. In this study, transcriptomic and metabolomic analyses of two cold-resistant lettuce cultivars (GWAS-W42 and F11) and two cold-sensitive lettuce cultivars (S13K079 and S15K058) were performed to identify the mechanisms involved in the cold response of lettuce. Overall, transcriptome analysis identified 605 differentially expressed genes, including significant enrichment of genes involved in the flavonoid and flavonol (CHS, CHI, F3H, FLS, CYP75B1, HCT, etc) biosynthetic pathways related to oxidation-reduction and catalytic activity. Untargeted metabolomic analysis identified fifteen flavonoid metabolites and 28 other metabolites potentially involved in the response to cold stress; genistein, quercitrin, quercetin derivatives, kaempferol derivatives, luteolin derivatives, apigenin and their derivatives accumulate at higher levels in cold-resistant cultivars. Moreover, MYBs, bHLHs, WRKYs and Dofs were also plays positively role in the low temperature response, which affected the expression of structural genes contributing to the variation of metabolites between the resistant and sensitive. These results provide valuable evidence that the metabolites and genes involved in the flavonoid biosynthesis pathway play important roles in the response of lettuce to cold stress.
Evaluation of the Kolcaba’s comfort theory combined ERAS care in patients with nasal deformities: study protocol of a randomized controlled trial
Authors: Wang Yue , Zeng Qianlin , Zhang Qi , Tian Yu , Fan Yunping , Sun Yueqi , Guan Jiaoqiong , Deng Yunping 
Published: January 2024

Abstract
Background
Patients with nasal deformities (ND) in the perioperative period face a multitude of physical and psychological issues. This study aims to develop and assess the efficacy of specialized nursing interventions based on Kolcaba's Comfort Theory in conjunction with Enhanced Recovery After Surgery (KCT-ERAS) tailored for ND patients.
Methods and analysis:
The research team formulated a nursing intervention protocol through a systematic review of literature and expert consultation. This protocol will be evaluated via a randomized controlled trial. ND patients admitted to a single medical facility within a specific timeframe will be randomly allocated into two groups in a 1:1 ratio. The KCT-ERAS group will receive comprehensive nursing interventions, including preoperative care (environmental preparation, health education, psychological counseling, shared decision-making, dietary management, and adaptation training), intraoperative temperature and fluid management, and postoperative care (early mobilization and feeding, pain management, and specialized nasal nursing). In contrast, the control group will receive standard nursing care. Primary outcomes include the length of hospitalization (LOH), comfort levels, and nursing satisfaction. Secondary outcomes are complications, anxiety levels, sleep quality, specialty quality of life (SQOF), pain intensity, and dry mouth.
Discussion
This study establishes a scientifically-backed perioperative care protocol for ND patients based on evidence-based medicine. The KCT-ERAS model is expected to enhance recovery outcomes for patients undergoing ND corrective surgery, offering a scientifically-informed, patient-centric nursing approach during the ND perioperative period.
Trial registration:
It has been approved by China Clinical Trial Registry on December 7, 2023 (No. ChiCTR2300078407).
Is child growth monitoring and promotion service utilization is adequate in Ethiopia: A systematic review and meta-analysis
Authors: Muhammad Esmael Ali , Sisay Mekonnen , Baffa Lemlem Daniel , Gasahw Moges , Mengistu Berhanu , Kassie Belayneh Ayanaw , Agimas Muluken Chanie , Abriham Zufan Yiheyis , Angaw Dessie Ababaw , Ahmed Medina Abdela , Belew Aysheshim kassahun 
Published: January 2024

Abstract
Background
Appropriate nutritional intervention in the first two years of life could break the intergenerational linkage of malnutrition that leads to physical and cognitive problems. To break this linkage, the preventive method; Growth monitoring and promotion (GM) is recommended to identify growth problems early and prevent physical and cognitive deficits in young children. However, according to the national report, GMP utilization in Ethiopia is below the UNICEF standard (80%). Therefore, the aim of this review was to systematically and quantitatively summarize the factors affecting the utilization of growth monitoring.
Method
We searched PubMed, Medline, EMBASE, Google Scholar, and Google for studies that had been conducted in Ethiopia. Searches were using the English language. A preferred reporting item for systematic reviews and meta-analysis (PRISMA) checklist was used. Two authors independently reviewed the studies. The effect sizes of the meta-analysis were the utilization of GMP service utilization and the adjusted odds ratio (AOR) of the associated factors We summarized the studies on the use of growth monitoring service utilization quantitatively and qualitatively. A random-effects model was conducted to obtain the pooled estimates.
Result
A total of nine observational studies were included in this review. The pooled prevalence of GMP service utilization in Ethiopia was 26.0% (95% CI: 19.00–33.00). The pooled odds ratio showed that a significant association was found between utilization of GMP and the age of child (AOR = 2.68; 95% CI: 1.95–3.69). Wealth index status (AOR = 1.76; 95% CI: 1.67–1.86), counseling about GMP (AOR = 1.72; 95% CI: 1.44–2.05) Media accessibility (AOR = 1.16; 95% CI: 1.10–1.23) and maternal attitude about GMP (AOR = 1.22; 95% CI: 1.17–1.28)
Conclusion
Utilization of growth monitoring and promotion service in Ethiopia remains low. The age of the child, media accessibility, wealth index status, and maternal attitude about GMP were significantly associated with service utilization. Primary attention should be given to maternal attitudes towards GMP and counseling about GMP to improve service utilization of GMP in Ethiopia.
Alleviating or institutionalizing greenwashing? – The inclusion of nuclear energy into the EU taxonomy from a narrative discourse perspective
Authors: Elsner Carsten 
Published: January 2024

Abstract

This paper analyses the discourse around the inclusion of nuclear energy into the EU Taxonomy which promises to provide standards for the question if an economic activity is sustainable or not. The idea is to guide financial means into sustainable areas of the economy and accumulate private investments for the transformation of the economy against climate change. In this regard, the question whether nuclear energy is sustainable was heavily debated and fought over. Through the application of a narrative discourse analysis, relying on expert interviews and media articles, this paper finds that the discourse shifted throughout the process. While a general sustainability discussion around the question if the technology nuclear energy is sustainable characterized the early discourse, a shift towards a process related discussion around how nuclear energy found its way into the EU Taxonomy can be observed at a later stage. Furthermore, the discourse was structured by several key events which provided focal points for discussion and influenced the storylines of proponents and opponents of nuclear energy.
RETRACTED: Establishment of Iranian Pediatric Thrombosis Registry (IPTR) by Iranian Society of Thrombosis and Hemostasis (IRSTH): A Preliminary Report
Authors: Kamfar Sharareh , Alavi Samin , Eshghi Peyman , Tabatabaie Morteza , Taherian Reza 
Published: January 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Effects of a lifestyle programme on objectively measured physical activity level and sedentary time on overweight and obese women of Somali background living in Norway Running
Authors: Andersen Eivind , Bohler Linn , Leirbakk Maria J. , Cabral Danielle , Wedegren Mia C. , Wieland Mark L. , Meyer Haakon E. , Madar Ahmed A. 
Published: January 2024

Abstract

Background
Given the elevated prevalence and impact of overweight and the potential risk of non-communicable diseases among women of Somali background in high-income countries and recognising the potential positive impact of physical activity (PA) on these health conditions, it becomes imperative to focus on understanding the PA behaviour of this specific population. The objectives of this paper were twofold: firstly, to provide a comprehensive description of both objectively and subjectively measured PA level and sedentary time in a group of overweight women of Somali background in Norway, and secondly, to assess the effectiveness of a tailored, culturally sensitive, and community-based intervention in enhancing PA levels and reducing sedentary time.
Methods
169 overweight women of Somali background in Norway were randomised by borough to either a lifestyle programme or a comparison group. The programme consisted of two sessions per week for 12 weeks, combining classroom discussion with graded group-based PA activity led by coaches, followed by monthly sessions over nine months. PA was measured objectively using the ActivPAL monitor and subjectively using the international PA questionnaire short form (IPAQ).
Results
The women took on average 6804 (SD = 3286) steps per day and were sedentary for 9.1 hours (SD = 3) per day at baseline. There were no differences between groups on any objectively measured PA variable at any timepoint. There were significant differences on vigorous intensity PA and total PA at the 12-month measurement session between the two groups using the IPAQ.
Conclusion
Despite observing initially low PA levels and high sedentary time at baseline and thus a considerable potential for intervention, the intervention failed in attaining an increase in objectively measured PA or reduction in sedentary time compared to the control condition. However, self-reported measures indicated success in these aspects. The potential threats to the programme's reliability and validity include contamination, low attendance rates, and high drop-out rates possible due to the COVID-19 pandemic. These challenges underscore the complexity of interventions in this demographic, emphasising the need for further exploration and refinement of study methodologies to effectively enhance PA levels and reduce sedentary time in immigrant women living in high-income countries.
Trial registration
: clinicaltrials.gov NCT04578067. Keywords: Immigrant Somali women, Lifestyle programme, Overweight, Physical activity, Sedentary time, ActivPAL
Systematic identification of R2R3-MYB S6 subfamily genes in Brassicaceae and its role in anthocyanin biosynthesis in Brassica crops
Authors: Chen Daozong , Wang Chenchen , Liu Yi , Shen Wenjie , Cuimu Qiushi , Zhang Dawei , Zhu Bo , Chen Lunlin , Tan Chen 
Published: January 2024

Abstract
The Brassicaceae family encompasses various plants, including the widely studied Arabidopsis thaliana and several vegetables and oil crops that hold significant economic importance as human food sources. The S6 subfamily's R2R3-MYB genes play a crucial role in regulating anthocyanin biosynthesis in plants, however, their systematic identification in Brassicaceae plants remains incomplete. Notably, Brassica crops have undergone significant genomic changes, including tripling and post-natural hybridization doubling events, during their long evolutionary journey after diverging from Arabidopsis. Consequently, the copy number of R2R3-MYB genes has experienced substantial alterations, and its functions may be significantly differentiated. Hence, Brassica crops present an optimal model for investigating copy number variation and functional divergence of S6 subfamily R2R3-MYB genes. In this investigation, we systematically identified 31 homologous genes of R2R3-MYB transcription factors belonging to the S6 subfamily in Brassicaceae. A total of 92 homologous genes were identified, with species representation ranging from 0 to 10. Phylogenetic analysis revealed the classification of these homologous genes into six distinct groups. Notably, approximately 70% of the homologous genes were found within the G6 group, suggesting a high degree of evolutionary conservation. Moreover, a phylogenetic analysis was performed on 35 homologous genes obtained from six species belonging to the Brassica U's triangle. The findings provided evidence of high conservation among orthologous genes across species and demonstrated strong collinearity on subgenomic chromosomes. However, notable tandem duplications were observed on chromosomes A7 and C6. Subsequently, the cis-acting elements of these 35 homologous genes were predicted, and their structures, conserved motifs, and characteristic conserved domains were analyzed. Once again, the results confirmed the significant similarities between orthologous genes. Simultaneously, we employed white and purple flower rapeseed specimens to perform qRT-PCR validation of the principal genes and transcriptional regulators associated with the anthocyanin synthesis pathway. The outcomes revealed a significant differential expression of BnaPAP2.A7.b in purple flowers, alongside the differential expression of BnaPAP2.C6.d. Ultimately, drawing upon prior research findings and the findings of this investigation, a transcriptional regulatory framework was proposed to govern anthocyanin accumulation in distinct tissues or organs of B. napus. The findings of our study offer novel perspectives on the functional diversification of R2R3-MYB transcription factors within the S6 subfamily homologous genes, while also shedding light on the regulatory network governing anthocyanin biosynthesis in species belonging to the Brassicaceae family.