bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Single‐Electrode Generator for Water Droplet Energy Harvesting with A 3 mA Current Output
Authors: Meng Jie , Zhang Liqiang , Liu Hongmei , Sun Weixiang , Wang Wenqi , Wang Hanchao , Yang Di , Feng Min , Feng Yange , Wang Daoai 
Published: December 2023

AbstractTriboelectric nanogenerators (TENGs) based on water droplets can harvest water kinetic energy using triboelectrification and electrostatic induction mechanisms. However, the development of traditional liquid–solid TENGs (L–S TENGs) is severely limited due to their low‐performance output and high device encapsulation requirements for preparation technology. In this work, a single‐electrode mode droplet‐based TENG (D‐TENG) is devised to effectively harvest water kinetic energy by optimizing the interface contact behavior of droplets, increasing the short‐circuit current (ISC) of one drop of water from microamperes to milliamperes levels. In the D‐TENG configuration, the electrode is positioned above the dielectric rather than at the bottom, allowing efficient utilization of generated friction charges and reducing the dissipation of these charges, thereby enhancing the output performance of the TENG. The influencing factors and operational mechanisms of D‐TENG are studied to obtain optimized working conditions to improve its output performance. Under optimal conditions, the D‐TENG can saturate the charge of the PTFE surface with only 8 droplets, achieving an ISC of up to 3.51 mA and an output voltage (VO) of 298.27 V. This work provides a convenient method for efficiently harvesting water kinetic energy based on interfacial behavior control.
Enhanced Methanol Synthesis over Self‐Limited ZnOx Overlayers on Cu Nanoparticles Formed via Gas‐Phase Migration Route
Authors: Song Tongyuan , Li Rongtan , Wang Jianyang , Dong Cui , Feng Xiaohui , Ning Yanxiao , Mu Rentao , Fu Qiang 
Published: December 2023

AbstractSupported metal catalysts are widely used for chemical conversion, in which construction of high density metal‐oxide or oxide‐metal interface is an important means to improve their reaction performance. Here, Cu@ZnOx encapsulation structure has been in situ constructed through gas‐phase migration of Zn species from ZnO particles onto surface of Cu nanoparticles under CO2 hydrogenation atmosphere at 450 °C. The gas‐phase deposition of Zn species onto the Cu surface and growth of ZnOx overlayer is self‐limited under the high temperature and redox gas (CO2/H2) conditions. Accordingly, high density ZnOx‐Cu interface sites can be effectively tailored to have an enhanced activity in CO2 hydrogenation to methanol. This work reveals a new route for the construction of active oxide‐metal interface and classic strong metal‐support interaction state through gas‐phase migration of support species induced by high temperature redox reaction atmosphere.
Quantitative N‐ or C‐Terminal Labelling of Proteins with Unactivated Peptides by Use of Sortases and a d‐Aminopeptidase
Authors: Arnott Zoe L. P. , Morgan Holly E. , Hollingsworth Kristian , Stevenson Charlotte M. E. , Collins Lawrence J. , Tamasanu Alexandra , Machin Darren C. , Dolan Jonathan P. , Kamiński Tomasz P. , Wildsmith Gemma C. , Williamson Daniel J. , Pickles Isabelle B. , Warriner Stuart L. , Turnbull W. Bruce , Webb Michael E. 
Published: December 2023

AbstractQuantitative and selective labelling of proteins is widely used in both academic and industrial laboratories, and catalytic labelling of proteins using transpeptidases, such as sortases, has proved to be a popular strategy for such selective modification. A major challenge for this class of enzymes is that the majority of procedures require an excess of the labelling reagent or, alternatively, activated substrates rather than simple commercially sourced peptides. We report the use of a coupled enzyme strategy which enables quantitative N‐ and C‐terminal labelling of proteins using unactivated labelling peptides. The use of an aminopeptidase in conjunction with a transpeptidase allows sequence‐specific degradation of the peptide by‐product, shifting the equilibrium to favor product formation, which greatly enhances the reaction efficiency. Subsequent optimisation of the reaction allows N‐terminal labelling of proteins using essentially equimolar ratios of peptide label to protein and C‐terminal labelling with only a small excess. Minimizing the amount of substrate required for quantitative labelling has the potential to improve industrial processes and facilitate the use of transpeptidation as a method for protein labelling.
Symmetry Breaking Enhancing the Activity of Electrocatalytic CO2 Reduction on an Icosahedron‐Kernel Cluster by Cu Atoms Regulation
Authors: Tan Yesen , Sun Guilin , Jiang Tingting , Liu Dong , Li Qinzhen , Yang Sha , Chai Jinsong , Gao Shan , Yu Haizhu , Zhu Manzhou 
Published: December 2023

AbstractRecently, CO2 hydrogenation had a new breakthrough resulting from the design of catalysts to effectively activate linear CO2 with symmetry‐breaking sites. However, understanding the relationship between symmetry‐breaking sites and catalytic activity at the atomic level is still a great challenge. In this study, a set of gold‐copper alloy Au13Cux (x=0–4) nanoclusters were used as research objects to show the symmetry‐controlled breaking structure on the surface of nanoclusters with the help of manipulability of the Cu atoms. Among them, Au13Cu3 nanocluster displays the highest degree of symmetry‐breaking on its crystal structure compared with the other nanoclusters in the family. Where the three copper atoms occupying the surface of the icosahedral kernel unevenly with one copper atom is coordinately unsaturated (CuS2 motif relative to CuS3 motif). As expected, Au13Cu3 has an excellent hydrogenation activity of CO2, in which the current density is as high as 70 mA cm−2 (−0.97 V) and the maximum FECO reaches 99 % at −0.58 V. Through the combination of crystal structures and theoretical calculations, the excellent catalytic activity of Au13Cu3 is revealed to be indeed closely related to its asymmetric structure.
Highly Efficient Spatially–Temporally Synchronized Construction of Robust Li3PO4‐rich Solid–Electrolyte Interphases in Aqueous Li‐ion Batteries
Authors: Zhu Xiangzhen , Lin Zejing , Lai Jingning , Lv Tianshi , Lin Ting , Pan Hongyi , Feng Jingnan , Wang Qiyu , Han Shuai , Chen Renjie , Chen Liquan , Suo Liumin 
Published: December 2023

AbstractSolid electrolyte interphase (SEI) makes the electrochemical window of aqueous electrolytes beyond the thermodynamics limitation of water. However, achieving the energetic and robust SEI is more challenging in aqueous electrolytes because the low SEI formation efficiency (SFE) only contributed from anion‐reduced products, and the low SEI formation quality (SFQ) negatively impacted by the hydrogen evolution, resulting in a high Li loss to compensate for SEI formation. Herein, we propose a highly efficient strategy to construct Spatially‐Temporally Synchronized (STS) robust SEI by the involvement of synergistic chemical precipitation‐electrochemical reduction. In this case, a robust Li3PO4‐rich SEI enables intelligent inherent growth at the active site of the hydrogen by the chemical capture of the OH− stemmed from the HER to trigger the ionization balance of dihydrogen phosphate (H2PO4−) shift to insoluble solid Li3PO4. It is worth highlighting that the Li3PO4 formation does not extra‐consume lithium derived from the cathode but makes good use of the product of HER (OH−), prompting the SEI to achieve 100 % SFE and pushing the HER potential into −1.8 V vs. Ag/AgCl. This energetic and robust SEI offers a new way to achieve anion/concentration‐independent interfacial chemistry for the aqueous batteries.
Synthesis and evaluation of dioctyl 2,5‐thiophenedicarboxylate as a potentially bio‐based plasticizer for poly(vinyl chloride)
Authors: Meng Qingliang , Dong Yunxiao , Yang Yong , Wang Jinggang , Li Juan , Zhu Jin 
Published: December 2023

AbstractIn this work, dioctyl 2,5‐thiophenedicarboxylate (DOT), a potentially bio‐based plasticizer, was synthesized and evaluated as an alternative to traditional petroleum‐based plasticizers. The chemical structure of DOT was confirmed by FTIR and 1H NMR. Besides, its plasticization effect on poly(vinyl chloride) (PVC) was investigated in detail, and dioctyl 2,5‐furandicarboxylate (DOF) as well as dioctyl isophthalate (DOIP) with similar chemical structures were used as references. The DMA results showed that the glass transition temperature (Tg) of PVC/DOT, PVC/DOF, and PVC/DOIP was 45.1°C, 33.6°C, and 51.3°C, respectively, indicating that the plasticizing efficiency of DOT was better than that of DOIP but lower than that of DOF. However, the tensile test results exhibited that the elongation at the break of PVC/DOT was higher than that of PVC/DOF, which was attributed to the easy phase separation between DOF and PVC. In addition, DOT displayed the best volatility resistance and exudation resistance among the three plasticizers, attributed to its highest molecular weight. Moreover, the migration loss of DOT in non‐polar solvents was much smaller than that of DOIP because of its stronger molecular polarity. In conclusion, DOT has good potential to replace traditional petroleum‐based plasticizers and be used as a primary plasticizer for PVC.
Novel FSH receptor heterodimer may be related to the high prolificacy of Jintang black goat
Authors: Cao Ye , Zhao Sujun , Chu Mingxing , Di Ran , Liu Yufang , Liu Li , Zhang Xueqin , Qian Shaoping , Zhang Yizheng 
Published: December 2023

AbstractFollicle‐stimulating hormone (FSH) is the central hormone of the mammalian reproductive system. It targets the FSH receptor (FSHR), a member of the G protein‐coupled receptor family, to induce the FSH signal transduction. In the highly prolific Jintang black goat, gonadotropin level is not higher than that of Boer goat. However, two isoforms of FSHRs (FSHRA and FSHRB), generated from the alternative splicing of the same primary FSHR transcript, were expressed in the reproductive organs of Jintang black goat simultaneously. The mRNA level of FSHRB is 45.89, 3.80, and 13.81 times greater than that of FSHRA in the hypothalamus, pituitary, and ovary of the Jintang black goat, respectively. We found that FSHRA could interact with FSHRB protein, leading to augment of the FSH signaling transduction pathway. The enhancement of FSH signaling could increase the in vitro oocyte maturation rate. It implied that this might be the important reason for the high prolificacy in Jintang black goat.
Adaptive path planning and tracking system based on model predictive control for autonomous vehicle local obstacle avoidance
Authors: Zhang Lixia , Ge Wuyi , Pan Fuquan , Li Baogang , Zhao Kun 
Published: December 2023

AbstractPath planning and tracking control are the key technologies of autonomous vehicle. The planned path and tracking results affect driving stability and safety directly. In this paper, an improved local path planning method based on model predictive control is proposed to match the variation of vehicle speed and road adhesion coefficient. A two‐layer model predictive control (MPC) path planning and tracking system is further designed to validate the method and the simulation results show that the proposed solution solves the problem of excessive avoidance and reduces the lateral deviation with the reference path.
Developing nanosize carrier systems for Amphotericin‐B: A review on the biomedical application of nanoparticles for the treatment of leishmaniasis and fungal infections
Authors: Sharifi Neda , Alitaneh Zahra , Asadi Sahar , Vahidinia Zeinab , Aghaei Zarch Seyed Mohsen , Esmaeili Ali , Bagheri‐Mohammadi Saeid , Najafi Sajad , Mazhari Yosra 
Published: December 2023

AbstractNew formulations of Amphotericin‐B (Am‐B), the most popular therapeutic drug for many human infections such as parasitic and fungal pathogens, are safe, economical, and effective in the world. Several newly designed carrier systems for Am‐B can also be considered orally with sufficient gastrointestinal permeability and good solubility. However, the clinical application of several new formulations of Am‐B with organ cytotoxicity, low bioavailability, high costs, and technical problems have caused some issues. Therefore, more attention and scientific design are required to progress safe and effective drug delivery systems. Currently, the application of nano‐based technology and nanomaterials in the advancement of drug delivery systems exhibits promising outcomes to cure many human systemic infections. Designing novel drug delivery systems including solid lipid nanostructured materials, lipo‐polymersomes, drug conjugates and microneedles, liposomes, polymer and protein‐based nanostructured materials, dendrimers, emulsions, mixed micelles, polymeric micelles, cyclodextrins, nanocapsules, and nanocochleate for Am‐B has many advantages to reducing several related issues. The unique properties of nanostructured particles such as proper morphology, small size, surface coatings, and, electrical charge, permit scientists to design new nanocomposite materials against microorganisms for application in various human diseases. These features have made these nanoparticles an ideal candidate for drug delivery systems in clinical approaches to cure a number of human disorders and currently, several therapeutic nanostructured material formulations are under different stages of clinical tests. Hence, this scientific paper mainly discussed the advances in new formulations of Am‐B for the treatment of human systemic infections and related clinical tests.
Anatomic prognostic factors and their potential roles in refining M1 classification for de novo metastatic nasopharyngeal carcinoma
Authors: Lu Tian‐Zhu , Zeng Fu‐juan , Hu Yu‐Jun , Fang Min , Zhong Fang‐yan , Chen Bi‐juan , Zhang Hao , Guo Qiao‐juan , Pan Jian‐ji , Gong Xiao‐chang , Huang Shao Hui , Liao Zhao‐hui , Xia Yunfei , Li Jin‐gao 
Published: December 2023

AbstractBackground and PurposeTo identify anatomic prognostic factors and their potential roles in refining M1 classification for de novo metastatic nasopharyngeal carcinoma (M1‐NPC).Materials and MethodsAll M1‐NPC treated with chemotherapy and/or radiotherapy between 2010 and 2019 from two centers (training and validation cohort) were included. The prognostic value of metastatic disease extent and involved organs for overall survival (OS) were assessed by several multivariable analyses (MVA) models. A new M1 classification was proposed and validated in a separate cohort who received immuno‐chemotherapy.ResultsA total of 197 M1‐NPC in the training and 307 in the validation cohorts were included for M1 subdivision study with median follow‐up of 46 and 57 months. MVA model with “≤2 organs/≤5 lesions” as the definition of oligometastasis had the highest C‐index (0.623) versus others (0.606–0.621). Patients with oligometastasis had better OS versus polymetastasis (hazard ratio [HR] 0.47/0.63) while liver metastases carried worse OS (HR 1.57/1.45) in MVA in the training/validation cohorts, respectively. We proposed to divide M1‐NPC into M1a (oligometastasis without liver metastases) and M1b (liver metastases or polymetastasis) with 3‐year OS of 66.5%/31.7% and 64.9%/35.0% in the training/validation cohorts, respectively. M1a subset had a better median progress‐free survival (not reach vs. 17 months, p < 0.001) in the immuno‐chemotherapy cohort (n = 163).ConclusionOligometastasis (≤2 organs/≤5 lesions) and liver metastasis are prognostic for M1‐NPC. Subdivision of M1‐NPC into M1a (oligometastasis without liver metastasis) and M1b (liver metastasis or polymetastasis) depicts the prognosis well in M1‐NPC patients who received immuno‐chemotherapy.
‘To succeed at work, you just need to work hard’: How beliefs in professional meritocracy serve to blame unemployed people
Authors: Rauscher Charlotte , Louvet Eva , Bourguignon David 
Published: December 2023

AbstractUnemployed people constitute a stigmatized group. They are perceived as lazy hucksters who could find a job if they just really tried. The aim of the present work was to identify mechanisms underlying this negative perception of unemployment in the context of intergroup relationships. Specifically, we focused on the influence of meritocratic beliefs on the tendency to attribute unemployment to the unemployed individuals themselves. In three experimental studies, participants had to explain the situation of a person presented either as ‘working’ or as ‘looking for a job’. Before this task and in an ostensible unrelated study, meritocratic beliefs were measured. Results showed that participants high in meritocratic beliefs explained unemployment less externally and more internally than participants low in meritocratic beliefs. Interestingly, these differences in causal attributions between high and low meritocratic believers appeared specifically for unemployment in Studies 1 and 2. Taken together, these results suggest that high meritocratic believers tend to consider that unemployed individuals are responsible for their unfortunate situation and have only themselves to blame. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Parietin, the Vibrant Natural Dye in Xanthoria parietina
Authors: Mendili Mohamed , Khadhri Ayda , Sabatini Francesca , Degano Ilaria , Aschi‐Smiti Samira 
Published: December 2023

AbstractThe use of natural dyes in several areas is regulated by current European and non‐European legislation, due to various problems with synthetic dyes. The analysis revealed that the lichen studied: Xanthoria parietina has potential natural dye sources and provides bright colors for extraction solvents. Furthermore, dyed wool and toile fabric have good fastness properties in ammonia fermentation and boiling water, both with and without mordants. The sample dyes with Xanthoria parietina were characterized by several analytical techniques: high‐performance liquid chromatography with diode array detection (HPLC‐DAD) and electrospray ionization with tandem mass spectrometry (HPLC‐ESI‐Q‐ToF). As compounds from Xanthoria parietina form a complex with mordants and tissues, it is impossible to identify the molecules responsible for coloring using chromatographic techniques. However, we have evaluated the dyeing power of their major molecule, parietin. To further confirm the coloring power of the isolated parietin molecule, we performed a dye test with pure parietin. Thus, CIALAB analyses have shown parietin is the molecule responsible for the coloring obtained by Xanthoria parietina. The utilization of parietin derived from lichens facilitates the development of sustainable dyes for textile coloring, presenting an environmentally friendly alternative to synthetic dyes while simultaneously enriching lichen biodiversity.
Histone globular domain epigenetic modifications: The regulators of chromatin dynamics in malaria parasite
Authors: Jabeena C. A. , Rajavelu Arumugam 
Published: December 2023

AbstractPlasmodium species adapt a complex lifecycle with multiple phenotypes to survive inside various cell types of humans and mosquitoes. Stage‐specific gene expression in the developmental stages of parasites is tightly controlled in Plasmodium species; however, the underlying mechanisms have yet to be explored. Genome organization and gene expression for each stage of the malaria parasite need to be better characterized. Recent studies indicated that epigenetic modifications of histone proteins play a vital role in chromatin plasticity. Like other eukaryotes, Plasmodium species N‐terminal tail modifications form a distinct “histone code,” which creates the docking sites for histone reader proteins, including gene activator/repressor complexes, to regulate gene expression. The emerging research findings shed light on various unconventional epigenetic changes in histone proteins′ core/globular domain regions, which might contribute to the chromatin organization in different developmental stages of the malaria parasite. The malaria parasite lost many transcription factors during evolution, and it is proposed that the nature of local chromatin structure essentially regulates the stage‐specific gene expression. This review highlights recent discoveries of unconventional histone globular domain epigenetic modifications and their functions in regulating chromatin structure dynamics in various developmental stages of malaria parasites.
A unique presentation of metaplastic breast carcinoma, NOS: A case report
Authors: Mremi Alex , Mwakyembe Theresia Edward , Suleman Mujaheed , Lodhia Jay 
Published: December 2023

Key Clinical MessageA rare form of invasive breast carcinoma, NOS, also known as matrix‐producing carcinoma made up of epithelial and mesenchymal components. Usually, they are triple negative and clinically aggressive and respond poorly to neoadjuvant systemic therapy.AbstractMetaplastic breast carcinomas (MBCs) are ductal carcinomas that undergo metaplasia to form nonglandular growth patterns. They are extremely rare, constituting less than 1% of all invasive breast carcinomas. Matrix‐producing carcinoma is an exceedingly rare form of MBC distinguished by a ductal carcinomatous component with direct transition to areas of cartilaginous or osseous differentiation without the presence of an intervening spindle cell element. MBCs are clinically aggressive, but matrix‐producing subtypes have a relatively better prognosis. The tumors are usually triple negative. Therefore, surgery and chemotherapy are the main therapeutic approaches. Our report describes this unique form of MBC with prominent osseous differentiation in a 33‐year‐old female patient. Its distinct histological features and peculiar clinical behavior necessitate a thorough understanding of this one‐of‐a‐kind disease entity.
Photo‐Controllable Ultralong Room‐Temperature Phosphorescence: State of the Art
Authors: Nie Fei , Yan Dongpeng 
Published: December 2023

AbstractIn this concept, we showcase the upsurge in the studies of dynamic ultralong room‐temperature phosphorescence (RTP) materials containing inorganic and/or organic components as versatile photo‐responsive platforms. The goal is to provide a comprehensive analysis of photo‐controllable RTP, and meanwhile delve into the underlying RTP properties of various classes of photochromic materials including metal‐organic complexes, organic‐inorganic co‐crystals, purely organic small molecules and organic polymers. In particular, the design principles governing the integration of the photochromic and RTP moieties within a single material system, and the tuning of dynamic RTP in response to light are emphasized. As such, this concept sheds light on the challenges and opportunities of using these tunable RTP materials for potential applications in optoelectronics, particularly highlighting their use of reversible information encryption, erasable light printing and rewritable smart paper.