bluuebunny/crossref_metadata_2025_split huggingface dataset:
The current landscape and emerging challenges of benchmarking single-cell methods
Authors: Cao Yue , Yu Lijia , Torkel Marni , Kim Sanghyun , Lin Yingxin , Yang Pengyi , Speed Terence P , Ghazanfar Shila , Yang Jean Yee Hwa 
Published: December 2023

AbstractWith the rapid development of computational methods for single-cell sequencing data, benchmarking serves as a valuable resource. As the number of benchmarking studies surges, it is timely to assess the current state of the field. We conducted a systematic literature search and assessed 282 papers, including all 130 benchmark-only papers from the search and an additional 152 method development papers containing benchmarking. This collective effort provides the most comprehensive quantitative summary of the current landscape of single-cell benchmarking studies. We examine performances across nine broad categories, including often ignored aspects such as role of datasets, robustness of methods and downstream evaluation. Our analysis highlights challenges such as how to effectively combine knowledge across multiple benchmarking studies and in what ways can the community recognise the risk and prevent benchmarking fatigue. This paper highlights the importance of adopting a community-led research paradigm to tackle these challenges and establish best practice standards.
Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung
Authors: Muir Andrew , Paudyal Basudev , Schmidt Selma , Sedaghat-Rostami Ehsan , Chakravarti Soumendu , Hernández Sonia Villanueva , Moffat Katy , Polo Noemi , Angelopoulos Nicos , Schmidt Anna , Tenbusch Matthias , Freimanis Graham , Gerner Wilhelm , Richard Arianne C. , Tchilian Elma 
Published: December 2023

AbstractThe pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans and swine. Swine have many physiological, anatomical, and immunological similarities to humans, and are an excellent model for human influenza. Here, we employed single RNA-sequencing (scRNA-seq) and flow cytometry to characterize the major leucocyte subsets in bronchoalveolar lavage (BAL), twenty-one days after H1N1pdm09 infection or respiratory immunization with an adenoviral vector vaccine expressing haemagglutinin and nucleoprotein with or without IL-1β. Mapping scRNA-seq clusters from BAL onto those previously described in peripheral blood facilitated annotation and highlighted differences between tissue resident and circulating immune cells. ScRNA-seq data and functional assays revealed lasting impacts of immune challenge on BAL populations. First, mucosal administration of IL-1β reduced the number of functionally active Treg. Second, influenza infection upregulated IFI6 in BAL cells, decreasing their susceptibility to virus replicationin vitro. Our data provides a reference map of porcine BAL cells and reveals lasting immunological consequences of influenza infection and respiratory immunisation in a highly relevant large animal model for respiratory virus infection.Author SummaryPigs and humans have a similar anatomy and physiology. In humans, cells from lung-washes are used to study immune responses and it was shown that these cells are crucial in protection against respiratory diseases such as influenza and COVID-19. To better understand lung immunity, we compared genes expressed in cells of pig lung-wash to white blood cells, providing an atlas for future studies of immunity in the lung. We also tested a vaccine given to the lung containing IL-1β, a strong immune activator that protects mice against influenza virus infection. However, although IL-1β increased pig immune responses it did not protect pigs against infection. We also showed that the number of immune cells that dampen immune responses (regulatory T cells) is reduced. In addition, we demonstrated increased expression of a protein, IFI6, 21 days after infection showing that while immune cells in the lung have common properties, the invading organisms influence them significantly. Our study elucidates why some vaccines fail despite inducing powerful immune responses, emphasizes the need for caution when applying results from small animals like mice to humans, and indicates the importance of the pig as a model to study disease in humans and livestock.
The membrane curvature inducing REEP1 proteins generate a novel ER-derived vesicular compartment
Authors: Shibata Yoko , Mazur Emily E. , Pan Buyan , Hernandez Sebastien V. , Zhang Jiuchun , Rapoport Tom A. 
Published: December 2023

AbstractThe endoplasmic reticulum (ER) is shaped by abundant, membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of REEP1-4 in mammals, differs in abundance and topology from REEP5. Mutations in REEP1 and REEP2 cause Hereditary Spastic Paraplegia, but REEP1-4’s function remains enigmatic. Here we show that the REEP1 proteins reside in a novel vesicular compartment and identify features that determine their localization. Mutations in REEP1 proteins that compromise curvature-inducing activity, including those that cause disease, relocalize the proteins to the bulk ER. These mutants interact with wildtype proteins to retain them in the ER, consistent with their autosomal-dominant disease inheritance. REEP1vesicles contain the fusogen atlastin-1, but not general ER proteins. We propose that REEP1 proteins generate these vesicles themselves by budding directly from the ER, and that they cycle back to the ER by atlastin-mediated fusion. The vesicles may serve to regulate ER tubule dynamics.
Mediating role of quality of work life between work-related social capital and life satisfaction among health professionals
Authors: Rashid Irfana , Amin Faseeh 
Published: December 2023

PurposeThe main aim of this study is to highlight the significance of fostering social capital and improving the quality of work life (QWL) for the well-being of healthcare workers. The second objective of this research is to address a notable gap in the current knowledge by examining the mediating influence of QWL on the relationship between work-related social capital and life satisfaction within the healthcare profession.Design/methodology/approachThis study used a cross-sectional research methodology to examine the complex relationships among the variables and included a sample of 330 individuals who are employed full-time in the healthcare profession in the North Indian Region.FindingsThe study confirms all research hypotheses, showing that social capital improves work life. Thus, work-life quality improves life satisfaction significantly. The mediation analysis in this study used bootstrapping to show that work-life quality mediates the association between social capital and life satisfaction.Practical implicationsAddressing social support issues and using effective human resource management tactics can improve employees’ work life and satisfaction. The findings are essential in collectivistic cultures because strong workplace relationships improve professional welfare.Originality/valueThis study differentiates itself by analysing social capital and QWL as multi-dimensional constructs inside the workplace, ensuring the results’ correctness and validity. This study provides a distinct viewpoint for scholars and practitioners, enhancing comprehension of the correlation between life satisfaction and work-related social capital within the healthcare industry.
Last-mile distribution and commodity availability, security and access: the moderating role of supply chain integration
Authors: Adusei Samuel , Nuertey Dorcas , Poku Emmanuel 
Published: December 2023

PurposeThis study investigated the relationship between last-mile distribution or delivery (LMD) and commodity access through the mediating role of commodity availability and commodity security and the moderating effect of supply chain integration (SCI).Design/methodology/approachThe study adopted the survey research design and employed the questionnaire instrument in collecting primary data from respondents in Eastern Regional Health Institutions in Ghana. The total number of valid responses received was 204. The partial least squares structural equation modeling (PLS-SEM) approach was adopted to analyze the relationship between the study variables.FindingsThe findings showed that there is a positive and significant relationship between LMD and commodity availability as well as LMD and commodity security. Moreover, while the relationship between commodity availability and commodity access is positive and significant, that between commodity security and commodity access is positive but insignificant. Furthermore, there is a positive and statistically significant relationship between LMD and commodity access. The study discovered that the interaction between LMD and commodity access is insignificant and negatively affected by SCI.Originality/valueTo the best of the authors' knowledge, no previous studies have empirically verified the effect of LMD on commodity access in the presence of mediating factors such as commodity availability and commodity security and SCI as the moderating factors.
Boundary violations and teleworker counterproductive work behavior: the role of working time demands, threat to family role and involuntary teleworking
Authors: Xu Nan , Tang Chunyong , Yang Chengchuan , Lai Yanzhao 
Published: December 2023

Purpose
Drawing on cognitive appraisal theory, this study aims to explore the indirect effect of work/family boundary violations on teleworkers’ counterproductive work behavior (CWB). In addition, it examines the moderating role of involuntary teleworking in this context.

Design/methodology/approach
Based on the diary study method, this study used 543 questionnaires collected from 122 teleworkers in China.

Findings
The findings indicate that working time demands mediate the relationship between work boundary violations and teleworker CWB, and threats to family roles mediate the relationship between family boundary violations and teleworker CWB. In addition, involuntary teleworking positively moderates the relationship between work boundary violations and working time demands, as well as the relationship between family boundary violations and threats to family roles.

Originality/value
The study makes several valuable contributions to the extant literature. First, it enhances research on the antecedents of teleworker CWB. Second, by introducing two mediating variables corresponding to two types of boundary violations, the paper provides new insights and a fresh understanding of the effects of boundary violations in teleworking situations. Third, by considering the moderating role of involuntary teleworking, this research adds to the current knowledge on the impact of discussing boundary violations solely on teleworking or traditional office days.
Environmental responsibility of family businesses: a perspective paper
Authors: Dasanayaka Chamila H. , Gunarathne Nuwan , Murphy David F. 
Published: December 2023

PurposeThis perspective paper explores ongoing research into stimuli that promote environmental responsibility in family business contexts. It also delineates emerging patterns and possible directions for future research within this domain.Design/methodology/approachThe authors synthesise, critically assess and integrate existing research to make current thinking about the environmental responsibility of family businesses more accessible to a wide range of readers.FindingsThis paper offers a comprehensive overview of multifaceted triggers and sheds light on how they interact and influence the environmental performance of family businesses. The authors delve into family dynamics and values, examining how they enable a business to develop environmental responsibility practices. Simultaneously, the authors emphasise the importance of probing the impact of the macro environment within which family businesses operate, which either might incentivise or challenge their pursuit of environmental responsibility initiatives. The need to design a robust tool to measure the environmental consciousness of familiness, applicable to specific contextual settings, has been identified. Investigating how accounting and control systems act as supportive management tools to enhance the efficacy of overall corporate performance in family businesses is another area for future research. Moreover, examining these dynamics within the unique landscape of emerging economies offers a promising field of exploration.Originality/valueThis article consolidates existing research on the environmental responsibility of family businesses and puts forward potential avenues for future research.
Enhancing firm performance through innovation: the roles of intellectual capital, government support, knowledge sharing and knowledge management success
Authors: Truong Binh Thi Thanh , Nguyen Phuong V. , Vrontis Demetris 
Published: December 2023

PurposeThis study determines whether government support for innovation (GSFI), knowledge sharing, knowledge management success (KMS) and intellectual capital (IC) strengthens the relationship between firm innovation and performance in the manufacturing industry in Vietnam.Design/methodology/approachA theoretical model and related hypotheses on manufacturers in Vietnam were developed based on the resource-based view and knowledge-based view. Data were collected from 361 respondents through a structured questionnaire and analyzed by partial least squares-structural equation modeling.FindingsGSFI and IC significantly and positively influence firm innovation and performance. However, knowledge sharing does not affect firm innovation. Moreover, KMS fully mediates the positive relationship between knowledge sharing and firm innovation, and firm innovation partially mediates the positive relationships of IC and government support with firm performance.Practical implicationsThe findings show how managers can utilize IC, KMS and government assistance to maximize the benefits of innovative outcomes and improve business performance.Originality/valueThis groundbreaking study creates a research model incorporating IC, knowledge sharing, KMS, GSFI, firm innovation and firm performance by extending two theories. Although the effects of various intangible assets on firm performance have been discussed extensively in the literature, there has been limited focus on the significance of KMS, knowledge sharing, IC and GSFI for enhancing innovative outcomes and driving business success in emerging markets such as Vietnam.
IFLA 2023: connecting librarians and information professionals
Authors: Oyelude Adetoun A. 
Published: December 2023

Purpose
The purpose of this paper is to report the 2023 conference of the International Federation of Library Associations and Institutions (IFLA) conference activities for 2023 as held in Rotterdam, The Netherlands from 21 to 25 August.

Design/methodology/approach
A report of the events that spanned five days, especially the aspects that hinged on technology use in libraries globally are highlighted. Narrative of the experiences during the conference is made from the participatory observation standpoint.

Findings
Librarians globally are connecting and collaborating. They use technology in their libraries and research into ways and means of collaborating more. Library associations globally are making impact especially in the use of artificial intelligence in service delivery. All sections of IFLA are active in working together and librarying!

Originality/value
The IFLA 2023 conference is one-of-a-kind experience in the library association world. Libraries and librarians globally are finding out new things yearly and the year 2023 is no different.
Experimental exploration of mechanical behaviour of graphene oxide blend polymer nanocomposites
Authors: G. Manikandaraja , R. Pandiyarajan , A. Vasanthanathan , S. Sabarish 
Published: December 2023

Purpose
This study aims to evaluate the development of composites made of epoxy (E) resin with different weight percentages of polypropylene (PP) and graphene oxide (Go) to form nanocomposite plates.

Design/methodology/approach
A hand lay-up process was used to develop 21 different composites, with varying concentrations of PP (5%–35%) and Go (5%–35%). A ternary composite of E matrix was produced by combining binary fillers PP and Go (5%–35%) in a 1:1 ratio to a (95%–5%) solution. With the help of adopting the melt condensation deal to extract Go, the modified Hummers method was used to make Go platelets.

Findings
Through field emission scanning electron microscopy (FESEM) and X-ray diffraction investigations, the particulate’s size and structural characteristics were identified. Based on the FESEM analysis of the collapsed zones of the composites, a warp-and-weft-like structure is evident, which endorses the growth yield strength, flexural modulus and impact strength of the composites.

Originality/value
The developed nanocomposites have exceptional mechanical capabilities compared to plain E resin, with E resin exhibiting better tensile strength, modulus and flexural strength when combined with 10% PP and 10% Go. When compared to neat E resin, materials formed from composites have exceptional mechanical properties. When mixed with 10% PP and 10% Go, E resin in particular displays improved tensile strength (23 MPa), tensile modulus (4.15 GPa), flexural strength (75.6 MPa) and other attributes. Engineering implications include automobile side door panels, spacecraft applications, brake pads and flexible battery guards.
Phygital marketing through the lens of neuroscience and phenomenology: an interpretivist account
Authors: Johnson Matt , Barlow Rob 
Published: December 2023

PurposeThe purpose of this paper is to explore the prospect of using neurophenomenology to understand, design and test phygital consumer experiences. It aims to clarify interpretivist approaches to consumer neuroscience, wherein theoretical models of individual phenomenology can be combined with modern neuroimaging techniques to detect and interpret the first-person accounts of phygital experiences.Design/methodology/approachThe argument is conceptual in nature, building its position through synthesizing insights from phenomenology, phygital marketing, theoretical neuroscience and other related fields.FindingsUltimately, the paper presents the argument that interpretivist neuroscience in general, and neurophenomenology specifically, provides a valuable new perspective on phygital marketing experiences. In particular, we argue that the approach to studying first-personal experiences within the phygital domain can be significantly refined by adopting this perspective.Research limitations/implicationsOne of the primary goals of this paper is to stimulate a novel approach to interpretivist phygital research, and in doing so, provide a foundation by which the impact of phygital interventions can be empirically tested through neuroscience, and through which future research into this topic can be developed. As such, the success of such an approach is yet untested.Originality/valuePhygital marketing is distinguished by its focus on the quality of subjective first-personal consumer experiences, but few papers to date have explored how neuroscience can be used as a tool for exploring these inner landscapes. This paper addresses this lacuna by providing a novel perspective on “interpretivist neuroscience” and proposes ways that current neuroscientific models can be used as a practical methodology for addressing these questions.
Integration of lean manufacturing and factory physics in an Industry 4.0 roadmap for augmenting operational performance
Authors: Utiyama Marcel , Alliprandini Dario Henrique , Figuerôa Hillary Pinto , Gondim Jonas Ferreira , Gonçalves Lucas Tollendal , Navas Lorena Braga , Zeno Henrique 
Published: December 2023

PurposeThe advent of Industry 4.0 (I4.0) and the requirements imposed on companies still need to be clarified. Companies still strive to understand I4.0 requirements and technological, organizational, operational and management challenges. Current literature on I4.0 underlies the importance of a roadmap with structured steps to achieve the benefits of I4.0, mainly focused on augmenting operational performance. Therefore, this paper proposes a roadmap to implement I4.0 focused on operational management concepts, mainly aiming to augment operational performance and bridge the gap between theory and practice regarding roadmaps focused on the operational management dimension.Design/methodology/approachThis paper follows a research approach divided into the following stages: a literature review to analyze the I4.0 roadmaps and identify the main components of I4.0; development of the proposed I4.0 roadmap presented; field research to test the roadmap by collecting data from a manufacturing company in the automotive industry; validation of the roadmap through modeling and simulation.FindingsThe authors presented a production line design with real-time control, fast response, shop floor coordination and predictive capacity. The results prove that the proposed I4.0 roadmap augments operation performance in the investigated automotive company. The main results were work in process reduction, lead time reduction, output increase, real-time control, shop floor coordination and fast response.Originality/valueThe main novelty of the proposed roadmap is to move toward I4.0 implementation with a focus on the operational management dimension. The roadmap has an innovative combination of the two approaches – lean manufacturing and factory physics – a straightforward roadmap with only three steps: (1) requirements, (2) real-time control and (3) predictive capacity, a structured definition of the approaches and operational management concepts fundamental in each step.
Estimating the anisotropy of the vertical transverse isotropy coal seam by rock physics model–based inversion
Authors: Wu Haibo , Guo Jinran , Ji Guangzhong , Huang Yaping , Ding Hai , Lin Peng 
Published: December 2023

AbstractCoal seams exhibiting nearly horizontal bedding, and fractures can be characterized as transversely isotropic media with a vertical axis of symmetry, known as vertical transverse isotropy coal seams. The resulting anisotropy cannot be overlooked in high‐precision seismic velocity analysis, migration imaging and pre‐stack inversion. Therefore, we estimate the anisotropy of the vertical transverse isotropy coal seam (using the anisotropic Thomsen's parameters ε, γ and δ) by inverting the horizontal P‐ and SH‐wave velocities and fracture density based on a rock physics model. The Mori–Tanaka model and Brown–Korringa formula were first used to quantify the anisotropy of the vertical transverse isotropy coal seams impacted by dry and fluid‐saturated fractures. Subsequently, we formulated an equation for the inversion of horizontal P‐ and SH‐wave velocities, considering the measured vertical P‐ and SH‐wave velocities as constrained parameters. This approach is generally applied in vertical drilling scenarios. We tested the inversion method using the ultrasonic test results of coal samples collected from the southern margin of the Qinshui Basin, China and then used it on the full waveform logging data from a vertical coalbed methane well. Both the inversion results of horizontal P‐ and SH‐wave velocities and the estimated anisotropic parameters (ε and γ) were in good agreement with the ultrasonic test results of coal samples, although the accuracy of δ was slightly lower. Therefore, we believe that the proposed method can be extended to estimate the anisotropy of vertical transverse isotropy medium (assuming suitable rock physics models) for the ultrasonic testing of rock samples and full waveform logging along the vertical direction in near‐horizontal formations.