bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food as medicine: a quasi-randomized control trial of two healthy food interventions for chronic disease management among ambulatory patients at an urban academic center
Authors: Kibera Peris W. , Ofei-Tenkorang Nana A. , Mullen Chanda , Lear Aaron M. , Davidson Elliot B. 
Published: December 2023

Abstract

Background:
Globally, poor nutrition is a driver of many chronic diseases and is responsible for more deaths than any other risk factor. Accordingly, there is growing interest in the direct provision of healthy foods to patients to tackle diet-linked chronic diseases and mortality.

Aim:
To assess the effect of two healthy food interventions in conjunction with nutrition counseling and education on select chronic disease markers, food insecurity, diet quality, depression, and on self-efficacy for healthy eating, healthy weight, and chronic disease management.

Methods:
This parallel-arm quasi-randomized control trial will be conducted between January 2022 and December 2023. Seventy adult patients recruited from a single academic medical center will be randomly assigned to receive either: i) daily ready-made frozen healthy meals or ii) a weekly produce box and recipes for 15 weeks. Participants will, additionally, take part in one individual nutrition therapy session and watch videos on healthy eating, weight loss, type 2 diabetes, and hypertension. Data on weight, height, glycated hemoglobin, blood pressure, and diabetes and blood pressure medications will be collected in-person at the baseline visit and at 16 weeks from baseline and via medical chart review at six months and 12 months from enrollment. The primary outcome of the study is weight loss at 16 weeks from baseline. Pre- and post-intervention survey data will be analyzed for changes in food insecurity, diet quality, depression, as well as self-efficacy for health eating, healthy weight, and chronic disease management. Through retrospective chart review, patients who received standard of care will be matched to intervention group participants as controls based on body mass index, type 2 diabetes, and/or hypertension.

Findings:
By elucidating the healthy food intervention with better health outcomes, this study aims to offer evidence that can guide providers in their recommendations for healthy eating options to patients.
A New Highly Parameterized Linear Inversion of Water Table Change and Groundwater Depletion Rate Tested With the High Plains Aquifer, U.S.A.
Authors: Jiao Jianying , Zhang Ye , Befus Kevin M. 
Published: December 2023

AbstractUnderstanding groundwater resource dynamics is limited by the sparsity of observations of water levels, pumping rates, and hydraulic properties relative to their spatiotemporal heterogeneity. To address some of this complexity, we proposed a new highly parameterized linear inverse method to quantify water table change and groundwater depletion rate in unconfined aquifers that does not require initial or boundary conditions. The method requires linearization, and we tested the performance of six proposed water table functions with three coordinate systems with synthetic models, finding that water table functions by the dimensionless method achieve the lowest errors. Our inverted water table changes and depletion rates remained stable and accurate with head measurement error of 5%. However, inversions became less accurate when head observations contained large temporal gaps. Next, we applied the inversion for water table changes and depletion rates in the Texas High Plains Aquifer (HPA) and the HPA during 2000–2015. To address sparse water levels and uncertain hydraulic conductivity measurements, two modifications were made to improve data constraints for inversion: (a) calculating winter‐time water levels for wells with >1 head observation by linear interpolation and (b) using hydraulic conductivity geostatistical realizations. The inverted water table change and depletion rate expected mean values and uncertainties were reasonable compared to the known pumping records of the Texas HPA. With relatively minor data curation, the new inverse method can quantify spatiotemporally continuous water table change, depletion rates, and their uncertainty for heterogeneous aquifers with temporally sparse and noisy water level observations.
Heatwave Duration and Heating Rate in a Non‐Stationary Climate: Spatiotemporal Pattern and Key Drivers
Authors: Chitsaz Fatemeh , Gohari Alireza , Najafi Mohammad Reza , Zareian Mohammad Javad , Haghighi Ali Torabi 
Published: December 2023

AbstractHeatwaves have had adverse affects on human life, ecosystems, and society. Global warming is expected to heighten the characteristics of heatwaves such as severity, duration, and frequency. Therefore, understanding the evolution of heatwaves is a central issue in climate change research with high relevance for society. Establishing a proper threshold for issuing a heatwave can be one of the most important issues in heatwaves studies, however, fewer studies focused on characterizing and modeling a heatwave threshold according to non‐stationary behavior, local geographic and physiographic characteristics. We have developed an applicable probabilistic framework to explore the heatwave events with different durations by applying appropriate thresholds. In this study, the proposed framework was applied to define the nonstationary frequency analysis of heatwaves models to account for the temporal trend caused by climate variability and change across Iran. The results showed that shorter heatwaves odds have been intensified more over Iran while longer heatwaves have not changed substantially. We find a substantial increase in heatwave hazard across Iran with a 40‐year available daily record, collectively from 1977 to 2019. The spatial distribution of the best non‐stationary models confirms the temporal evolution of heatwaves features due to global warming over Iran.
The 3‐Week‐Long Transport History and Deep Tropical Origin of the 2021 Extreme Heat Wave in the Pacific Northwest
Authors: Baier K. , Rubel M. , Stohl A. 
Published: December 2023

AbstractThe heat wave in late June of 2021 (PNW21) set new temperature records in the Pacific Northwest (PNW). In Lytton the highest temperature ever recorded in Canada was measured. Several studies have already explored this extreme event in detail, however, here we compare the atmospheric air mass transport and heating processes associated with this heat wave with the 34 other most extreme heat events in the same region during the period 1960–2021, using a long backtracking time of 25 days. We found significant differences in the heat waves. During PNW21 most of the air was coming from the Philippine Sea, with more than 40% of the air located south of 15°N, and anomalous advection of sensible and latent heat from the Tropics was the dominant cause of PNW21. The latent heat was efficiently converted into sensible heat by precipitation, which was unique, as most other extremes experienced net diabatic cooling.
Heterogeneous Diazotroph Communities in the Subtropical‐Subantarctic Transition and Aphotic Zones Off the Coast of Patagonia, Eastern South Pacific Ocean
Authors: Shiozaki Takuhei , Hirai Miho , Kondo Fumie , Sato Takuya , Sato Miyako , Iriarte José L. , Yokokawa Taichi , Nunoura Takuro , Harada Naomi 
Published: December 2023

AbstractSubtropical‐subpolar transition water is a potential domain for N2 fixation, but the understanding of N2 fixation in such waters remains incomplete. We simultaneously examined the N2 fixation activity and community structures of diazotrophs and all prokaryotes from the surface to just above the seafloor off Patagonia in the transitional region of the eastern South Pacific Ocean. N2 fixation activity was not detected in the surface waters, but was observed sporadically and only in subpolar bathypelagic waters (>1,000 m) at very low rates (0.02–0.06 nmol N L−1 d−1). By contrast, the nifH gene, a key gene involved in N2 fixation, was detected widely from the surface to the bottom waters. The majority of diazotrophs were classified as non‐cyanobacterial diazotrophs (NCDs), and the nifH amino acid sequences of major diazotrophs were similar to sequences detected in the Southern Ocean, the aphotic zone and sediment of other oceans, and estuarine waters, suggesting that the NCDs are distributed across diverse marine environments. The overall prokaryotic communities were generally similar to those in other open ocean regions at the phylum level (class level for Proteobacteria) and differed among water depths. Diazotrophs, in contrast, showed vertical and horizontal heterogeneity below the euphotic zone and little association with water depth, indicating a lack of cohesion within the community, which may characterize diazotroph community in the transitional surface water and aphotic zones. Elucidating this community heterogeneity may provide pivotal information about N2 fixation in these waters.
Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period
Authors: Ao Danyi , He Xuemei , Liu Jian , Xu Li 
Published: December 2023

AbstractThe spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant casualties and put immense strain on public health systems worldwide, leading to economic recession and social unrest. In response, various prevention and control strategies have been implemented globally, including vaccine and drug development and the promotion of preventive measures. Implementing these strategies has effectively curbed the transmission of the virus, reduced infection rates, and gradually restored normal social and economic activities. However, the mutations of SARS-CoV-2 have led to inevitable infections and reinfections, and the number of deaths continues to rise. Therefore, there is still a need to improve existing prevention and control strategies, mainly focusing on developing novel vaccines and drugs, expediting medical authorization processes, and keeping epidemic surveillance. These measures are crucial to combat the Coronavirus disease (COVID-19) pandemic and achieve sustained, long-term prevention, management, and disease control. Here, we summarized the characteristics of existing COVID-19 vaccines and drugs and suggested potential future directions for their development. Furthermore, we discussed the COVID-19-related policies implemented over the past years and presented some strategies for the future.
SLEEP quality in patients with psoriatic arthritis and its relationship with disease activity and comorbidities: a cross-sectional study
Authors: Toledano Esther , Hidalgo Cristina , Gómez-Lechón Luis , ibáñez Marta , Chacón Carolina Cristina , Martín-Vallejo Javier , Pastor Sonia , Montilla Carlos 
Published: December 2023

AbstractThe assessment of psoriatic arthritis is complex and multidimensional. It is increasingly common to include the patient perspective using patient-reported outcomes. Although some research has explored sleep quality in patients with psoriatic arthritis, most studies have had small sample sizes, failed to assess sleep quality considering the inflammatory process together with the psychological well-being of patients, and have not described any use of sleep medication. Further, research to date has not provided data on the relationship of sleep quality with axial forms. In this context, the objective of this study was to assess sleep quality in patients with psoriatic arthritis and its relationship with clinical characteristics, disease activity, functioning, disease impact, fatigue and psychological status. A cross-sectional study was conducted including 247 consecutive patients with PsA recruited during 2021. Sleep quality was measured using the Pittsburgh Sleep Quality Index. We assessed correlations of Pittsburgh Sleep Quality Index score with peripheral disease activity (Disease Activity Index for PSoriatic Arthritis), axial disease activity (Ankylosing Spondylitis Disease Activity Score-C-reactive protein and Bath Ankylosing Spondylitis Disease Activity Index), functioning (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire), impact (Psoriatic Arthritis Impact of Disease questionnaire), anxiety, depression (Hospital Anxiety and Depression Scale) and fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue) scores. A multiple linear regression model was constructed with PSQI as the dependent variable and as independent variables those that could influence sleep quality. Nearly two-thirds (63.15%) of patients had poor sleep quality. Poorer sleep quality was associated with being female, higher joint counts, greater peripheral and axial disease activity, fatigue, anxiety and depression, functioning and disease impact (p < 0.001). Multiple linear regression analysis found that pain (β: 0.3; p < 0.007) and fatigue β: − 0.1; p < 0.001 contributed 40% to the sleep quality model. Poor sleep quality was common among patients with psoriatic arthritis. Emotional factors (fatigue, anxiety) seemed more important than inflammatory factors in sleep quality.
Physiological mechanism of sodium salicylate and folcisteine on alleviating salt stress in wheat seedlings
Authors: Han Aohui , Wang Cuiling , Li Jingchong , Xu Li , Guo Xiaoyan , Li Weiguo , Zhou Feng , Liu Runqiang 
Published: December 2023

AbstractSoil salinization substantially hampers the growth and development of wheat, potentially leading to plant death in severe cases, thus reducing grain yield and quality. This phenomenon poses a significant threat to food security in China. We investigated the effects of two exogenous plant growth regulators, sodium salicylate and folcisteine, on the wheat physiology and key characteristics under salt stress using hydroponics method. The results indicated that both regulators effectively mitigated the growth inhibition of wheat under salt stress. We assessed morphological and physiological indexes, including antioxidant enzyme activities (superoxide dismutase [SOD], catalase [CAT], peroxidase [POD]) and malondialdehyde (MDA) concentration in wheat after foliar application of sodium salicylate and folcisteine under salt stress. The findings revealed that sodium salicylate was more effective than folcisteine. However, folcisteine showed superior performance in reducing hydrogen peroxide (H2O2) content and superoxide anion (O2−) level compared to sodium salicylate. Simultaneously, Concurrent application of both regulators synergistically enhanced their efficacy, yielding the most favorable outcomes. In addition, this study noted that while the initial effects of these regulators were not pronounced, their sustained application significantly improved wheat growth in stressful condition and alleviated the detrimental impacts of salt stress. This approach could effectively guarantee the food security and production in China.
Visualization of deglutition and gastroesophageal reflux using real-time MRI: a standardized approach to image acquisition and assessment
Authors: Biggemann Lorenz , Uhlig Johannes , Streit Ulrike , Al-Bourini Omar , Wedi Edris , Amanzada Ahmad , Ellenrieder Volker , Rühlmann Felix , Ghadimi Michael , Frahm Jens , Uecker Martin , Seif Amir Hosseini Ali 
Published: December 2023

AbstractThis study aims to develop a standardized algorithm for gastroesophageal image acquisition and diagnostic assessment using real-time MRI. Patients with GERD symptoms undergoing real-time MRI of the esophagus and esophagogastric junction between 2015 and 2018 were included. A 10 ml bolus of pineapple juice served as an oral contrast agent. Patients performed Valsalva maneuver to provoke reflux and hiatal hernia. Systematic MRI assessment included visual presence of achalasia, fundoplication failure in patients with previous surgical fundoplication, gastroesophageal reflux, and hiatal hernia. A total of 184 patients (n = 92 female [50%], mean age 52.7 ± 15.8 years) completed MRI studies without adverse events at a mean examination time of 15 min. Gastroesophageal reflux was evident in n = 117 (63.6%), hiatal hernia in n = 95 (52.5%), and achalasia in 4 patients (2.2%). Hiatal hernia was observed more frequently in patients with reflux at rest (n = 67 vs. n = 6, p < 0.01) and during Valsalva maneuver (n = 87 vs. n = 8, p < 0.01). Real-time MRI visualized a morphologic correlate for recurring GERD symptoms in 20/22 patients (90%) after fundoplication procedure. In a large-scale single-center cohort of patients with GERD symptoms undergoing real-time MRI, visual correlates for clinical symptoms were evident in most cases. The proposed assessment algorithm could aid in wider-spread utilization of real-time MRI and provides a comprehensive approach to this novel imaging modality.
Trends in the decapod crustacean community at the southernmost estuary of the Atlantic coast of Europe
Authors: González-Ortegón Enrique , de Carvalho-Souza Gustavo F. , Vilas Cesar , Baldó Francisco , Cuesta Jose A. 
Published: December 2023

AbstractClimate change may enhance the establishment of introduced species, as well as the poleward shift in distribution of numerous species over decades. Long-term research and monitoring of an ecosystem at the southernmost point of the Atlantic coast of Europe should be an important priority in order to detect and understand trends in species composition and the related environmental changes. The Guadalquivir estuary (South West Spain) is more likely to suffer the exacerbated effects of climate change due to its location in the Mediterranean-climate zone. The long-term data set between 1997 and 2006 has allowed us to analyse the variability of the natural and anthropogenic stressors. The mean interannual dissimilarity of the estuarine fauna (Bray–Curtis dissimilarity index) has showed important differences throughout the years, and the species that most contributed to these differences were the exotic species capable of completing their life cycles. This long-term monitoring of the estuarine community has allowed us to anticipate future events and ecological risk assessment in European waters.
Detecting groundwater level changes related to the 2016 Kumamoto Earthquake
Authors: Yamamoto Shun , Koike Katsuaki , Yamashiki Yosuke Alexandre , Shimada Jun 
Published: December 2023

AbstractThis study presented the first attempt to detect precursory changes in groundwater level before the 2016 Kumamoto Earthquake. This detection was achieved by accurately determining the relationship between long-term groundwater level fluctuation and crustal deformation over 16 years through analysis of groundwater level time-series data acquired at 17 sites within the study area. Here, we show that the observed groundwater levels were lower than the modelled levels in aquifers composed of porous strata (Togawa lava and part of the pre-Aso volcanic rocks), and that there were larger differences until 2014, which diminished until the occurrence of the Kumamoto Earthquake. The initial reduction in the modelled groundwater level and the latter recovery were most likely caused by crustal strain relaxation associated with the large 2011 earthquake off the Pacific coast of Tohoku (Mw 9.0) and the strain accumulation prior to the 2016 Kumamoto Earthquake.
Using machine learning to forecast domestic homicide via police data and super learning
Authors: Verrey Jacob , Ariel Barak , Harinam Vincent , Dillon Luke 
Published: December 2023

AbstractWe explore the feasibility of using machine learning on a police dataset to forecast domestic homicides. Existing forecasting instruments based on ordinary statistical instruments focus on non-fatal revictimization, produce outputs with limited predictive validity, or both. We implement a “super learner,” a machine learning paradigm that incorporates roughly a dozen machine learning models to increase the recall and AUC of forecasting using any one model. We purposely incorporate police records only, rather than multiple data sources, to illustrate the practice utility of the super learner, as additional datasets are often unavailable due to confidentiality considerations. Using London Metropolitan Police Service data, our model outperforms all extant domestic homicide forecasting tools: the super learner detects 77.64% of homicides, with a precision score of 18.61% and a 71.04% Area Under the Curve (AUC), which, collectively and severely, are assessed as “excellent.” Implications for theory, research, and practice are discussed.
Factors influencing the need and willingness for presbyopic correction: a cross sectional study from south India
Authors: Khurana Dhruval A. , Swathi N. , Rajalakshmi A. R. 
Published: December 2023

AbstractPresbyopia is an age-related physiological phenomenon in which eye gradually losses its ability to accommodate. It is one of the leading causes of visual impairment worldwide, especially in adults above the age of 40. If uncorrected, it can significantly impair a patient's quality of life. This study aims to evaluate the factors which affects patient’s need and willingness to accept presbyopic correction. This cross-sectional analytical study was carried out in a semi urban tertiary care hospital from Jan 2021 to June 2022 among patients aged 40 and above who presented to Outpatient department (OPD). Demographic details, medical history, presenting ocular complaints pertaining to presbyopia, spectacle use and decision regarding using near vision correction were noted. Ocular examination included refraction and ocular biometry. Factors that may have influenced complaints of presbyopia or willingness to accept presbyopic correction were analysed. Three hundred and forty two patients with a mean age of 48.55 ± 6.68 years were included. Of these, 262 (76.61%) patients presented with chief complaints related to presbyopia. Those with higher educational qualification (p = 0.031), hypermetropia (p = 0.021), shallower AC depth (p = 0.028) and on medications for systemic ailments (p = 0.01), were more likely to present with chief complaints attributable to presbyopia. Among them, those with higher educational qualifications (p = 0.02) and skilled workers were more likely to accept near vision glasses (p = 0.02), while those with lower Hb (p = 0.01) and myopia (p = 0.01) were less likely to accept correction for presbyopia. Among the 80 patients without chief complaints related to presbyopia, 35 (43.75%) were not willing to accept near vision glasses. Those with higher BMI (p = 0.04) and hypermetropes (p = 0.05) were more willing to accept presbyopic correction. Presbyopia constitutes a significant reason for patients above the age of 40 visiting eye care facility. Multiple socio-economic, systemic and ocular factors influenced both the chief complaints related to presbyopia and willingness to accept presbyopic correction.