bluuebunny/crossref_metadata_2025_split huggingface dataset:
La couronne comme institution, performance et processus politico-religieux
Authors: Ferrer-Bartomeu Jérémie , Mellet Paul-Alexis 
Published: November 2023

La couronne au XVI e siècle a rarement été étudiée. Pourtant, comme au Moyen Âge, elle y apparaît à la fois comme objet, signe et performance théologico-politique de l’exercice de la souveraineté, c’est-à-dire comme réalité matérielle et comme concept. Toutefois, dans une période déchirée par les guerres de Religion, les contestations radicales de l’autorité souveraine actualisent les enjeux et les débats qui entourent cet objet singulier. La couronne fonde-t-elle la souveraineté ? Celui qui la porte en est-il digne ? Quelles sont les conditions qui en garantissent la régularité de la transmission ? Le règne d’Henri III constitue un précipité dramatique de ces enjeux : d’abord quand en 1584 Henri de Navarre, protestant, devient héritier présomptif ; puis, en 1588, quand le roi fait assassiner le duc de Guise et le cardinal de Lorraine lors du coup de majesté des états généraux de Blois. Dès lors, dans une quête angoissée des origines, l’objet couronne se disjoint du chef du roi honni, à qui l’on dénie – comme on la dénie à son héritier hérétique – la souveraineté, la légitimité et in fine la dignité de ceindre la couronne de France. Ce qui se joue sous le règne d’Henri III, à travers la question de savoir à qui revient la couronne de France, c’est finalement une complexe articulation entre droit, hérédité, orthodoxie et dignité.
« Lieutenant général de l’État et couronne de France » (1589) : l’étrange titulature de Charles de Lorraine
Authors: Daubresse Sylvie 
Published: November 2023

L’exécution du duc de Guise et de son frère, le cardinal, ordonnée par Henri III provoque la révolte d’une grande partie des Français. Le 7 mars 1589, Charles de Lorraine, duc de Mayenne, dernier frère survivant des Guise, prend la tête du mouvement d’opposition, et devient « lieutenant général de l’État et de la couronne de France ». Le texte tend à montrer que cette titulature tout à fait inédite a contribué à l’affirmation du concept d’État, posé comme puissance abstraite et souveraine sans lien avec un individu physique, pendant les quatre années où la France fut sans roi incontesté, entre 1589 et 1594.
La couronne impériale : une histoire matérielle à l’époque moderne
Authors: Lebeau Christine 
Published: November 2023

L’article propose une histoire matérielle de la couronne qui ne se limite pas à la description de l’objet conçu au X e siècle et à l’étude de sa symbolique ou de sa garde mais ne veut pas non plus opposer histoire du droit et des cérémonies. Tracer la « vie sociale » de l’objet à l’époque moderne implique non seulement de s’intéresser à ses usages, principalement lors du couronnement impérial, mais aussi de comprendre comment la couronne fédère autant qu’elle distingue sans que nul ne puisse se l’approprier. Le couronnement de Charles VI (1711) est plus particulièrement étudié au prisme des actes de la pratique, des journaux de couronnement, des traités des juristes d’empire et de sa représentation.
Courtly banter in The Duchess of Malfi (iii.ii.1-57): not “so merry”
Authors: Valls-Russell Janice 
Published: November 2023

Situated midway through the play in the Duchess’s bedchamber, act III scene ii is the fulcrum of The Duchess of Malfi. The Duchess enters the scene and her bedchamber a free woman, she leaves it a virtual prisoner. Coming after two acts that have covered several years since the beginning of the play, this intense night scene unfolds in a swift succession of sequences, all revolving around the Duchess. This essay focuses on the first sequence, a domestic, seemingly light-hearted moment (lines 1-57) that brings together the Duchess, her husband, Antonio, and her maid, Cariola. Looking at the use of courtly rhetoric in a scene framed by references to personal appearance (jewellery and hairdo), this article suggests that the impression of happiness and the tropes of a wooing scene are undermined by a sense of displacement and inappropriateness. John Webster draws on recognisable codes to subvert them: the mythological references and conventions of courtly discourse are there, but in the wrong place. Words, props and gestures are transformed and distorted.
MUTYH-associated polyposis: Is it time to change upper gastrointestinal surveillance? A single-center case series and a literature overview
Authors: Sanchez-Mete Lupe , Mosciatti Lorenzo , Casadio Marco , Vittori Luigi , Martayan Aline , Stigliano Vittoria 
Published: November 2023

BACKGROUND
The presence of Spigelman stage (SS) IV duodenal polyposis is considered the most significant risk factor for duodenal cancer in patients with MUTYH -associated polyposis (MAP). However, advanced SS disease is rarely reported in MAP patients, and no clear recommendations on small bowel (SB) surveillance have been proposed in this patient setting.
AIM
To research more because that case reports of duodenal cancers in MAP suggest that they may develop in the absence of advanced benign SS disease and often involve the distal portion of the duodenum.
METHODS
We describe a series of MAP patients followed up at the Regina Elena National Cancer Institute of Rome (Italy). A literature overview on previously reported SB cancers in MAP is also provided.
RESULTS
We identified two (6%) SB adenocarcinomas with no previous history of duodenal polyposis. Our observations, supported by literature evidence, suggest that the formula for staging duodenal polyposis and predicting risk factors for distal duodenum and jejunal cancer may need to be adjusted to take this into account rather than focusing solely on the presence or absence of SS IV disease.
CONCLUSION
Our study emphasizes the need for further studies to define appropriate upper gastrointestinal surveillance programs in MAP patients.
Identification of necroptosis-related lncRNAs for prognosis prediction and screening of potential drugs in patients with colorectal cancer
Authors: Chen Zhi-Hua , Lin Yi-Lin , Chen Shao-Qin , Yang Xiao-Yu 
Published: November 2023

BACKGROUND
Tumor recurrence and metastasis lead to a poor prognosis in colorectal cancer (CRC). Necroptosis is closely related to the tumor microenvironment (TME) and affects tumor recurrence and metastasis. We aimed to stratify CRC patients according to necroptosis-related long noncoding RNAs (lncRNAs), which can be used to not only evaluate prognosis and improve precision medicine in clinical practice but also screen potential immunotherapy drugs.
AIM
To stratify CRC patients according to necroptosis-related lncRNAs (NRLs), which can be used to not only evaluate prognosis and improve precision medicine in clinical practice but also screen potential immunotherapy drugs.
METHODS
LncRNA expression profiles were collected from The Cancer Genome Atlas. NRLs were identified by coexpression analysis. Cox regression analysis identified a NRL signature. Then, the value of this signature was comprehensively and multidimensionally evaluated, and its reliability for CRC prognosis prediction was assessed with clinical CRC data and compared with that of six other lncRNA signatures. Gene set enrichment analysis, TME analysis and half-maximal inhibitory concentration (IC50) prediction were also performed according to the risk score (RS) of the signature.
RESULTS
An 8-lncRNA signature significantly associated with overall survival (OS) was constructed, and its reliability was validated with clinical CRC data. Most of the areas under the receiver operating characteristic curves (AUCs) values for 1-, 3- and 5-year OS for this signature were higher than those for the other six lncRNA signatures. OS, disease-specific survival and the progression-free interval were all significantly poorer in the high-risk group. The RS of the signature showed good concordance with the predicted prognosis, with AUCs for 1-, 3- and 5-year OS of 0.79, 0.81 and 0.77, respectively. Additionally, the calibration plots for this signature combined with clinical factors showed that this combination could effectively improve the ability to predict OS. The RS was correlated with tumor stage, lymph node metastasis and distant metastasis. Most of the enriched Kyoto Encyclopedia of Genes and Genomes and Gene Ontology terms were tumor metastasis-related pathways in the high-risk group; these patients showed greater infiltration of immunosuppressive cells, such as cancer-associated fibroblasts, hematopoietic stem cells and M2 macrophages, but less infiltration of infiltrating antitumor effector immune cells, such as cluster of differentiation 8+ T cells and regulatory T cells (Tregs). We explored additional potential immune checkpoint genes and potential immunotherapeutic and chemotherapeutic drugs with relatively low IC50 values.
CONCLUSION
We identified an NRL signature with strong fidelity that could stably predict prognosis and might be an indicator of the TME of CRC. Furthermore, additional potential immunotherapeutic and chemotherapeutic drugs were explored.
Pancreatic pseudoaneurysm mimicking pancreatic tumor: A case report and review of literature
Authors: Yang Yuan , Liu Xue-Mei , Li Hong-Ping , Xie Rui , Tuo Bi-Guang , Wu Hui-Chao 
Published: November 2023

BACKGROUND
Pancreatic pseudoaneurysm is a rare vascular complication of chronic pancreatitis (CP) or necrotizing pancreatitis with an incidence of 4% to 17%, but it is potentially life-threatening. It is well known that most pancreatic pseudoaneurysms are clinically associated with pancreatic pseudocysts and are usually in the peripancreatic body-tail. A minority of intrapancreatic pseudoaneurysms occur in the absence of pseudocyst formation. Noninvasive computed tomography (CT) and magnetic resonance imaging (MRI) are most commonly used examinations for screening pancreatic pseudoaneurysms. Notably, the rare intrapancreatic pseudoaneurysm in the pancreatic head can mimic a hypervascular solid mass and be misdiagnosed as a pancreatic tumor.
CASE SUMMARY
We report the case of a 67-year-old man who had been admitted to our hospital due to recurrent abdominal pain for 1 mo that was aggravated for 5 d. CT and MRI revealed a mass in the pancreatic head with significant expansion of the main pancreatic duct and mild atrophy of the pancreatic body-tail. He was admitted to the department of hepatobiliary and pancreatic surgery due to the possibility of a pancreatic tumor. The patient was then referred for endoscopic ultrasonography (EUS) with possible EUS-FNA. However, EUS showed a cystic lesion in the pancreatic head with wall thickness and enhancing nodules, which was doubtful because it was inconsistent with the imaging findings. Subsequently, color doppler flow imaging demonstrated turbulent arterial blood flow in the cystic lesion and connection with the surrounding vessel. Therefore, we highly suspected the possibility of CP complicated with intrapancreatic pseudoaneurysm, combined with the patient's long-term drinking history and the sonographic features of CP. Indeed, angiography revealed an oval area of contrast medium extravasation (size: 1.0 cm × 1.5 cm) at the far-end branch of the superior pancreaticoduodenal artery, and angiographic embolization was given immediately at the same time.
CONCLUSION
EUS is an important differential diagnostic tool when pancreatic pseudoaneurysm mimics the imaging appearance of a hypervascular pancreatic tumor.
Designing an Egocentric Video-Based Dashboard to Report Hand Performance Measures for Outpatient Rehabilitation of Cervical Spinal Cord Injury
Authors: Kadambi Adesh , Bandini Andrea , Ramkalawan Ryan D. , Hitzig Sander L. , Zariffa José 
Published: November 2023

Background
Functional use of the upper extremities (UEs) is a top recovery priority for individuals with cervical spinal cord injury (cSCI), but the inability to monitor recovery at home and limitations in hand function outcome measures impede optimal recovery.

Objectives
We developed a framework using wearable cameras to monitor hand use at home and aimed to identify the best way to report information to clinicians.

Methods
A dashboard was iteratively developed with clinician (n = 7) input through focus groups and interviews, creating low-fidelity prototypes based on recurring feedback until no new information emerged. Affinity diagramming was used to identify themes and subthemes from interview data. User stories were developed and mapped to specific features to create a high-fidelity prototype.

Results
Useful elements identified for a dashboard reporting hand performance included summaries to interpret graphs, a breakdown of hand posture and activity to provide context, video snippets to qualitatively view hand use at home, patient notes to understand patient satisfaction or struggles, and time series graphing of metrics to measure trends over time.

Conclusion
Involving end-users in the design process and breaking down user requirements into user stories helped identify necessary interface elements for reporting hand performance metrics to clinicians. Clinicians recognized the dashboard's potential to monitor rehabilitation progress, provide feedback on hand use, and track progress over time. Concerns were raised about the implementation into clinical practice, therefore further inquiry is needed to determine the tool's feasibility and usefulness in clinical practice for individuals with UE impairments.
Providing Insights into the Challenges of Implementing Activity-Based Therapy in Canada: A Comparative Analysis Using Focus Group Interviews with Key Interest Groups
Authors: Kaiser Anita , Chan Katherine , Sessford James , McCullum Shane , Athanasopoulos Peter , Rice Chris , Leo Jennifer , MacRitchie Iona , Zariffa José , Musselman Kristin E. 
Published: November 2023

BackgroundActivity-based therapy (ABT) has emerged as a therapeutic approach that may promote neurorecovery and reduce secondary complications in people living with spinal cord injury or disease (SCI/D). In spite of the numerous health benefits, adoption of ABT into practice has been limited across the Canadian care continuum.ObjectivesThis study aimed to understand the challenges of implementing ABT in Canada for people living with SCI/D through the perspectives of key interest groups.MethodsResearchers, hospital therapists, community trainers, administrators, persons living with SCI/D, and advocates, funders, and policy experts who had knowledge of and/or experience with ABT participated in focus group interviews to share their perspectives on the barriers to ABT practice. Interviews were analyzed using conventional content analysis followed by a comparative analysis across groups.ResultsThe 48 participants identified six key challenges: (1) challenge of gaps in knowledge/training, (2) challenge of standardizing ABT, (3) challenge of determining the optimal timing of ABT, (4) challenge of defining, characterizing, and achieving high dosage and intensity, (5) challenge of funding ABT, and (6) challenge of measuring participation and performance in ABT. A comparative analysis found some challenges were emphasized by certain groups, such as the cost of ABT for persons with SCI/D, lack of education and training in ABT for therapists and trainers, minimal evidence to develop guidelines for researchers and advocates, and funding ABT programs for administrators.ConclusionParticipants highlighted several challenges that limit ABT practice. Strategies to address these challenges will support successful implementation of ABT in Canada.
Combinatorial Effects of Transcutaneous Spinal Stimulation and Task-Specific Training to Enhance Hand Motor Output after Paralysis
Authors: Oh Jeonghoon , Scheffler Michelle S. , Mahan Erin E. , King Shane T. , Martin Catherine A. , Dinh Jenny , Steele Alexander G. , O’Malley Marcia K. , Sayenko Dimitry G. 
Published: November 2023

Background
Despite the positive results in upper limb (UL) motor recovery after using electrical neuromodulation in individuals after cervical spinal cord injury (SCI) or stroke, there has been limited exploration of potential benefits of combining task-specific hand grip training with transcutaneous electrical spinal stimulation (TSS) for individuals with UL paralysis.

Objectives
This study investigates the combinatorial effects of task-specific hand grip training and noninvasive TSS to enhance hand motor output after paralysis.

Methods
Four participants with cervical SCI classified as AIS A and B and two participants with cerebral stroke were recruited in this study. The effects of cervical TSS without grip training and during training with sham stimulation were contrasted with hand grip training with TSS. TSS was applied at midline over cervical spinal cord. During hand grip training, 5 to 10 seconds of voluntary contraction were repeated at a submaximum strength for approximately 10 minutes, three days per week for 4 weeks. Signals from hand grip dynamometer along with the electromyography (EMG) activity from UL muscles were recorded and displayed as visual feedback.

Results
Our case study series demonstrated that combined task-specific hand grip training and cervical TSS targeting the motor pools of distal muscles in the UL resulted in significant improvements in maximum hand grip strength. However, TSS alone or hand grip training alone showed limited effectiveness in improving grip strength.

Conclusion
Task-specific hand grip training combined with TSS can result in restoration of hand motor function in paralyzed upper limbs in individuals with cervical SCI and stroke.
Identifying Patterns of Primary Care Antibiotic Prescribing for a Spinal Cord Injury (SCI) Cohort Using an Electronic Medical Records (EMR) Database
Authors: Senthinathan Arrani , Penner Melanie , Tu Karen , Morris Andrew M. , Craven B. Catharine , Li Zhiyin , Guan Jun , Jaglal Susan B. 
Published: November 2023

BackgroundIndividuals with a spinal cord injury (SCI) are considered higher users of antibiotics. However, to date there have been no detailed studies investigating outpatient antibiotic use in this population.Objectives(1) To describe primary care antibiotic prescribing patterns in adults with SCI rostered to a primary care physician (PCP), and (2) to identify patient or PCP factors associated with number of antibiotics prescribed and antibiotic prescription duration.MethodsA retrospective cohort study using linked health administrative and electronic medical records (EMR) databases from January 1, 2013 to December 31, 2015 among 432 adults with SCI in Ontario, Canada. Negative binomial regression analyses were conducted to identify patient or physician factors associated with number of antibiotics prescribed and prescription duration.ResultsDuring the study period, 61.1% of the SCI cohort received an antibiotic prescription from their PCP. There were 59.8% of prescriptions for urinary tract infections (UTI) and 24.6% of prescriptions for fluoroquinolones. Regression analysis found catheter use was associated with increased number of antibiotics prescribed (relative risk [RR] = 3.1; 95% CI, 2.3-4.1; p &lt; .001) and late career PCPs, compared to early-career PCPs, prescribed a significantly longer duration (RR = 1.8; 95% CI, 1.1-3.1; p = .02).ConclusionUTIs were the number one prescription indication, and fluoroquinolones were the most prescribed antibiotic. Catheter use was associated with number of antibiotics, and PCP's years of practice was associated with duration. The study provided important information about primary care antibiotic prescribing in the SCI population and found that not all individuals received frequent antibiotics prescriptions.
Calibration of Arduino-based Temperature Sensors for Parabolic Solar Collectors with Phase Change Material
Authors: Ahmadi Ahmadi , Setiawan Adi , Gunawati Gunawati , Dewi Rozanna 
Published: November 2023

The development of energy storage materials requires facilities for testing the materials' ability to store and release energy effectively. This study focuses on the development and calibration of a temperature measurement system for parabolic solar collectors equipped with heat storage media. We employed type-K thermocouples and MAX6675 modules with Arduino as our measurement tools. The calibration process involved comparing sensor measurements with those obtained from commercially calibrated instruments using seven different test materials. The calibration results demonstrated that our sensors exhibited an error rate ranging from 0.66 to 0.73, indicating their accuracy and suitability for monitoring temperature fluctuations in solar thermal collectors.
Pengembangan material penyimpan energi thermal membutuhkan sarana untuk uji coba kemampuan bahan dalam menyimpan dan melepaskan energi. Penelitian ini fokus pada pengembangan dan kalibrasi sistem pengukuran temperatur untuk kolektor surya parabola yang memiliki media penyimpanan panas. Kami menggunakan sensor termokopel tipe-K dan modul MAX6675 dengan Arduino sebagai alat pengukuran. Proses kalibrasi melibatkan perbandingan hasil pengukuran sensor dengan alat komersil yang sudah terkalibrasi pada tujuh bahan uji yang berbeda. Hasil kalibrasi menunjukkan bahwa sensor kami memiliki tingkat kesalahan antara 0.66 hingga 0.73, menunjukkan bahwa sensor kami sudah akurat dan dapat digunakan untuk memonitor perubahan suhu pada kolektor surya termal.
Occupational Health and Safety Analysis Using HIRA and FTA Methods in the Silo Department of PT. XYZ
Authors: Na’am Muhammad Maulidun , Andesta Deny , Ismiyah Elly 
Published: November 2023

PT. XYZ is a wheat flour producer. To produce quality flour requires risky labor. Work accidents from 2014 to 2022 were evaluated based on secondary data. This research detects work accidents in the Silo Department using the Hazard Identification And Risk Analysis (HIRA) and Fault Tree Analysis (FTA) methods. HIRA is used to detect risks and causes of work accidents. There are six activities in a silo that have the potential to cause work accidents, namely: stairs without handrails, sample display areas without steps, top steps that are loose and protrude upwards, open dump truck doors, placement of elevator chains, and opening ventilation at the top of the silo. Based on the results of the FTA analysis, it is known that the causes of work accidents are caused by ladders not being suitable for use, workers not using PPE, workers not understanding the work flow, workers being tired, workers not concentrating, workers being in a hurry.
PT. XYZ adalah produsen tepung terigu. Untuk memproduksi tepung yang berkualitas memerlukan tenaga kerja yang berisiko. Kecelakaan kerja dari tahun 2014 hingga 2022 dievaluasi berdasarkan data sekunder. Penelitian ini mendeteksi kecelakaan kerja di Departemen Silo dengan menggunakan metode Hazard Identification And Risk Analysis (HIRA) dan Fault Tree Analysis (FTA). HIRA digunakan untuk mendeteksi risiko dan penyebab kecelakaan kerja. Terdapat enam aktivitas dalam silo yang berpotensi menimbulkan kecelakaan kerja, yaitu : tangga tanpa pegangan, area display sampel tanpa undakan, anak tangga paling atas yang kendur dan menonjol ke atas, pintu dump truck terbuka, penggantian rantai elevator, serta pembukaan ventilasi silo bagian atas. Berdasarkan hasil analisis FTA diketahui penyebab terjadinya kecelakaa kerja dikarenakan tangga tidak layak pakai, pekerja tidak menggunakan APD, pekerja tidak memahami alur kerja, pekerja dalam kondisi lelah pekerja tidak konsentrasi, pekerja tergesah-gesah.