bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the pharmacokinetic profile of the medicinal product Gidazepam®, tablets, 50 mg in a bioequivalence study
Authors: Baskakov E. V. , Grigorev A. V. , Globenko A. A. , Shmelev A. G. , Kolmykova E. A. , Yastrebova A. V. , Sidorova A. A. , Kapashin A. V. , Kovchan O. V. , Bashkatova A. I. , Pasko M. A. 
Published: November 2023

Aim. The primary aim of this study was to evaluate the pharmacokinetic parameters and conﬁrm the bioequivalence of drugs containing gidazepam, namely Gidazepam® (Valenta Pharm, Russia) and Gidazepam VIC (VIVA Pharm, Republic of Kazakhstan), after a single administration of 1 tablet (50 mg) to healthy volunteers under fasting conditions. The secondary aim was a comparative analysis of safety proﬁles (adverse events) after a single administration of the studied drugs.Materials and methods. An open, randomized, crossover, two-period comparative study of pharmacokinetics and bioequivalence with adaptive design was conducted in healthy volunteers. Blood sampling was performed 15 minutes before and 20 min, 40 min, 1 h, 2 h, 3 h, 3.5 h, 4 h, 4.5 h, 5 h, 6 h, 8 h, 12 h, 24 h, 48 h, and 72 h after drug administration. High-performance liquid chromatography-tandem mass spectrometry was used for the evaluation of gidazepam and its metabolite (desalkylgidazepam) concentration with the subsequent calculation of pharmacokinetic parameters.Results. From both formulations, gidazepam was quickly absorbed and biotransformed into an active metabolite. Studied drugs had similar pharmacokinetic proﬁles, as 90% conﬁdence intervals for the ratio of geometric means for Cmax and AUC(0-72) were within the bioequivalence acceptance range of 80.00–125.00 %. No adverse events were recorded as a result of clinical, laboratory or instrument evaluations during the study.Conclusion. Study drugs are considered bioequivalent and show comparable tolerability after a single administration under fasting conditions.
More powerful parameter tests? No, rather biased parameter estimates. Some reflections on path analysis with weighted composites
Authors: Schuberth Florian , Schamberger Tamara , Henseler Jörg 
Published: November 2023

AbstractRecently, a study compared the effect size and statistical power of covariance-based structural equation modeling (CB-SEM) and path analysis using various types of composite scores (Deng, L., & Yuan, K.-H., Behavior Research Methods,55, 1460–1479, 2023). This comparison uses nine empirical datasets to estimate eleven models. Based on the meta-comparison, that study concludes that path analysis via weighted composites yields “path coefficients with less relative errors, as reflected by greater effect size and statistical power” (ibidem, p. 1475). In our paper, we object to this central conclusion. We demonstrate that the justification these authors provided for comparing CB-SEM and path analysis via weighted composites is not well grounded. Similarly, we explain that their employed study design, i.e., a meta-comparison, is very limited in its ability to compare the effect size and power delivered across these methods. Finally, we replicated Deng and Yuan’s (ibidem) meta-comparison and show that CB-SEM using the normal-distribution-based maximum likelihood estimator does not necessarily deliver smaller effect sizes than path analysis via composites if a different scaling method is employed for CB-SEM.
FEATURES OF THE DEVELOPMENT OF A SYSTEM OF EXERCISES AND TASKS FOR TEACHING THE JOURNALISTIC STYLE OF SPEECH OF CHINESE INTERNS
Authors: Ян Сюецзяо 
Published: November 2023

Статья посвящена особенностям обучения китайских стажеров публицистическому стилю речи на уроках РКИ. Здесь рассматриваются основные характеристики текстов названной стилевой принадлежности, которые оказывают влияние на организацию системы упражнений при знакомстве китайских стажеров с такого рода текстовыми материалами. В результате автором очерчивается круг методических рекомендаций по работе с публицистическими текстами в иностранной аудитории.
This article is devoted to the peculiarities of teaching foreigners the journalistic style of speech in the lessons of Russian as a foreign language. The paper discusses the main characteristics of the texts of the named stylistic affiliation, which influence the organization of the system of exercises when Chinese trainees get acquainted with this kind of textual materials. As a result, the author outlines a range of methodological recommendations for working with journalistic texts in a foreign audience.
Artistic Text as a Source of Professionally Oriented Information for Arab Medical Students of the Preparatory Faculty (on the material of the poem by V. V. Mayakovsky Who to be)
Authors: Вострякова Н.А. 
Published: November 2023

В статье для арабских студентов-медиков базового уровня обучения РКИ предлагается многоаспектный национально и профессионально ориентированный комментарий к прецедентному для русской культуры стихотворению В. В. Маяковского «Кем быть?». Комментарий включает в себя сокращенный вариант этого стихотворения, лингвострановедческий текст о биографии его автора, учебно-научный текст о профессии педиатра и педиатрии, а также систему заданий, развивающую коммуникативные умения учащихся во всех видах речевой деятельности и обучающую их продуцированию высказываний о профессии детского врача на русском языке. Лексико-грамматическое содержание комментария согласовано с Лексическим минимумом базового уровня обучения и Программами общего и специального владения РКИ для студентов-медиков подготовительного факультета. Используемые в комментарии незнакомые слова переведены на арабский язык. Комментарий был апробирован со студентами-медиками подготовительного факультета из Ливана, Египта и Ирака.
The article for Arab medical students of the basic level of studying Russian as a foreign language offers a multi-aspect nationally and professionally oriented commentary on the poem by V. V. Mayakovsky Who to be. The commentary includes an abbreviated version of this poem, a linguo-cultural text about the biography of its author, an educational and scientific text about the profession of a pediatrician and pediatrics, as well as a system of tasks that develops the communication skills of students in all types of speech activity and teaches them to produce statements about the profession of a pediatrician in Russian. The lexical and grammatical content of the commentary is consistent with the Lexical minimum of the basic level of education and the Programs of General and Special Proficiency of Russian as a Foreign Language for Medical Students of the Preparatory Faculty. Unfamiliar words used in the commentary have been translated to Arabic. The commentary was tested with preparatory medical students from Lebanon, Egypt and Iraq.
Formation of communicative competence when teaching Russian as foreign at the initial stage in online and mixed formats: problems and prospects
Authors: Овсий Е.С. 
Published: November 2023

В статье рассматривается специфика формирования коммуникативной компетенции в онлайн- и смешанном форматах обучения РКИ. На основе изучения законодательства о дистанционном образовании, особенностях работы в формах обучения, которые стали более востребованными после эпидемии COVID-19, анализа методического наполнения онлайн-курсов и их структуры, а также результатов анкетирования преподавателей, слушателей подготовительных факультетов, студентов основных направлений подготовки делается прогнозирование перспектив использования онлайн-курсов для обучения РКИ, даются соответствующие рекомендации. Особое внимание уделяется ожиданиям слушателей и студентов от онлайн-курсов, изучающих РКИ.
The article discusses the specifics of the formation of communicative competence in online and mixed format of teaching Russian as a foreign language. Based on the study of the legislation on distance education, the peculiarities of work in the forms of education that have become more in demand after the COVID-19 epidemic, the analysis of the methodological content of online courses and their structure, as well as the results of the survey of teachers, students of preparatory faculties, students of the main areas of training, the prediction of the prospects for using online courses for teaching RFL is made, relevant recommendations. Particular attention is paid to the expectations of listeners and students from online courses learning Russian as a foreign language.
Commitment of the Head of the Ministry of Religious Affairs in Increasing the Motivation for Achievement of Teachers Raudhatul Athfal within the Ministry of Religious Affairs of Sarolangun Regency
Authors: Apriadi Apriadi , Maisah Maisah , Kusnadi Edi 
Published: November 2023

Commitment Head of the Ministry of Religious Affairs in increasing the motivation of outstanding teacher Raudhatul Athfal within the Ministry of Religious Affairs of Sarolangun Regency. Based on the grand tour found still lacking. The research method uses a qualitative descriptive approach. Data collection is carried out by observation, interview and documentation techniques. Determination of research subjects using the snawboll sampling technique. Data analysis techniques are carried out by data reduction, data presentation and conclusion drawing and verification of the reliability of research results obtained by techniques of extension of participation, accuracy of observation, triangulation andata. The results showed that. The commitment of the Head of the Ministry of Religious Affairs in increasing the motivation of outstanding teachers Raudhatul Atfhal within the Ministry of Religious Affairs of Sarolangun Regency can be in the form of spective, normative and sustainable commitments. The factors causing the lack of commitment of the Head of the Ministry of Religious Affairs in increasing the motivation for the achievement of Raudhatul Athfal teachers are First, the Internal Factors that exist in the Head of the Ministry of Religion itself lack the enthusiasm to motivate teachers Raudhatul Athfal.Second External Factors from outside the Head of the Ministry of Religion such as lack of cooperation with the community, Regional Government, Provincial Ministry of Religion and Central Ministry. The strategy of the Head of the Ministry of Religion for improving the Motivation for Teacher Achievement Raudhatul Athfal can be in the form of providing coaching, training and including seminars and improving higher education
Optimization of Future Multifilter Surveys Toward Asteroid Characterization
Authors: Klimczak Hanna , Wilawer Emil , Kwiatkowski Tomasz , Kryszczyńska Agnieszka , Oszkiewicz Dagmara , Kotłowski Wojciech , DeMeo Francesca 
Published: November 2023

Abstract
The aim of this paper is to find a set of photometric passbands that will give optimal results for spectrophotometric classification of asteroids into taxonomic types and classes. For this purpose various machine-learning methods are used, namely multinomial logistic regression, naive Bayes, support vector machines, gradient boosting, and multilayer perceptrons. Sequential feature selection is performed to assess the contribution of each reflectance difference. We find that to determine the taxonomic complexes with a balanced accuracy of 85%, a set of five spectrophotometric bands is required. For taxonomy type determination with the balanced accuracy of 80% a set of eight bands is necessary. Furthermore, only a three-band system is enough for distinguishing the C-complex asteroids with 92% balanced accuracy. These results can be used for designing future asteroid multifilter sky surveys.
Multicolor Photometry of Tiny Near-Earth Asteroid 2015 RN35 across a Wide Range of Phase Angles: Possible Mission-accessible A-type Asteroid
Authors: Beniyama Jin , Ohsawa Ryou , Avdellidou Chrysa , Sako Shigeyuki , Takita Satoshi , Ishiguro Masateru , Sekiguchi Tomohiko , Usui Fumihiko , Kinoshita Shinichi W. , Lee Kianhong , Takumi Asami , Ferrais Marin , Jehin Emmanuël 
Published: November 2023

Abstract
Studying small near-Earth asteroids is important in order to understand their dynamical histories and origins as well as to mitigate the damage caused by asteroid impacts on Earth. We report the results of multicolor photometry of the tiny near-Earth asteroid 2015 RN35 using the 3.8 m Seimei telescope in Japan and the TRAPPIST-South telescope in Chile over 17 nights in 2022 December and 2023 January. We observed 2015 RN35 across a wide range of phase angles from 2° to 30° in the g, r, i, and z bands in the Pan-STARRS system. These lightcurves show that 2015 RN35 is in a nonprincipal axis spin state with two characteristic periods of 1149.7 ± 0.3 s and 896.01 ± 0.01 s. We found that the slope of the visible spectrum of 2015 RN35 is as red as asteroid (269) Justitia, one of the very red objects in the main belt, which indicates that 2015 RN35 can be classified as an A- or Z-type asteroid. In conjunction with the shallow slope of the phase curve, we suppose that 2015 RN35 is a high-albedo A-type asteroid. We demonstrated that surface properties of tiny asteroids could be well constrained by intensive observations across a wide range of phase angles. 2015 RN35 is a possible mission-accessible A-type near-Earth asteroid with a small Δv of 11.801 km s−1 in the launch window between 2030 and 2035.
An Exploration of AGN and Stellar Feedback Effects in the Intergalactic Medium via the Low-redshift Lyα Forest
Authors: Tillman Megan Taylor , Burkhart Blakesley , Tonnesen Stephanie , Bird Simeon , Bryan Greg L. , Anglés-Alcázar Daniel , Hassan Sultan , Somerville Rachel S. , Davé Romeel , Marinacci Federico , Hernquist Lars , Vogelsberger Mark 
Published: November 2023

Abstract
We explore the role of galactic feedback on the low-redshift Lyα (Lyα) forest (z ≲ 2) statistics and its potential to alter the thermal state of the intergalactic medium. Using the Cosmology and Astrophysics with Machine Learning Simulations (CAMELS) suite, we explore variations of the AGN and stellar feedback models in the IllustrisTNG and Simba subgrid models. We find that both AGN and stellar feedback in Simba play a role in setting the Lyα forest column density distribution function (CDD) and the Doppler width (b-value) distribution. The Simba AGN jet feedback mode is able to efficiently transport energy out to the diffuse IGM, causing changes in the shape and normalization of the CDD and a broadening of the b-value distribution. We find that stellar feedback plays a prominent role in regulating supermassive black hole growth and feedback, highlighting the importance of constraining stellar and AGN feedback simultaneously. In IllustrisTNG, the AGN feedback variations explored in CAMELS do not affect the Lyα forest, but varying the stellar feedback model does produce subtle changes. Our results imply that the low-z Lyα forest can be sensitive to changes in the ultraviolet background, stellar and black hole feedback, and that AGN jet feedback in particular can have a strong effect on the thermal state of the IGM.
oMEGACat. I. MUSE Spectroscopy of 300,000 Stars within the Half-light Radius of ω Centauri
Authors: Nitschai M. S. , Neumayer N. , Clontz C. , Häberle M. , Seth A. C. , Husser T.-O. , Kamann S. , Alfaro-Cuello M. , Kacharov N. , Bellini A. , Dotter A. , Dreizler S. , Feldmeier-Krause A. , Latour M. , Libralato M. , Milone A. P. , Pechetti R. , van de Ven G. , Voggel K. , Weisz Daniel R. 
Published: November 2023

Abstract
Omega Centauri (ω Cen) is the most massive globular cluster of the Milky Way and has been the focus of many studies that reveal the complexity of its stellar populations and kinematics. However, most previous studies have used photometric and spectroscopic data sets with limited spatial or magnitude coverage, while we aim to investigate it having full spatial coverage out to its half-light radius and stars ranging from the main sequence to the tip of the red giant branch. This is the first paper in a new survey of ω Cen that combines uniform imaging and spectroscopic data out to its half-light radius to study its stellar populations, kinematics, and formation history. In this paper, we present an unprecedented MUSE spectroscopic data set combining 87 new MUSE pointings with previous observations collected from guaranteed time observations. We extract spectra of more than 300,000 stars reaching more than 2 magnitudes below the main-sequence turnoff. We use these spectra to derive metallicity and line-of-sight velocity measurements and determine robust uncertainties on these quantities using repeat measurements. Applying quality cuts we achieve signal-to-noise ratios (S/Ns) of 16.47/73.51 and mean metallicity errors of 0.174/0.031 dex for the main-sequence stars (18 mag <mag
F625W
< 22 mag) and red giant branch stars (16 mag <mag
F625W
< 10 mag), respectively. We correct the metallicities for atomic diffusion and identify foreground stars. This massive spectroscopic data set will enable future studies that will transform our understanding of ω Cen, allowing us to investigate the stellar populations, ages, and kinematics in great detail.
Evidence for a Correlation between Binary Black Hole Mass Ratio and Black Hole Spins
Authors: Adamcewicz Christian , Lasky Paul D. , Thrane Eric 
Published: November 2023

Abstract
The astrophysical origins of the binary black hole systems seen with gravitational waves are still not well understood. However, features in the distribution of black hole masses, spins, redshifts, and eccentricities provide clues into how these systems form. Much has been learned by investigating these distributions one parameter at a time. However, we can extract additional information by studying the covariance between pairs of parameters. Previous work has shown preliminary support for an anticorrelation between mass ratio q ≡ m
2/m
1 and effective inspiral spin χ
eff in the binary black hole population. In this study, we test for the existence of this anticorrelation using updated data from the third gravitational-wave transient catalog and improve our copula-based framework to employ a more robust model for black hole spins. We find evidence for an anticorrelation in (q, χ
eff) with 99.7% credibility. This may imply high common-envelope efficiencies, stages of super-Eddington accretion, or a tendency for binary black hole systems to undergo mass-ratio reversal during isolated evolution. Covariance in (q, χ
eff) may also be used to investigate the physics of tidal spinup as well as the properties of binary black hole–forming active galactic nuclei.
Understanding the Kinetic Energy Deposition within Molecular Clouds
Authors: Yuan Lixia , Yang Ji , Du Fujun , Su Yang , Zhang Shaobo , Yan Qing-Zeng , Sun Yan , Zhou Xin , Chen Xuepeng , Wang Hongchi , Chen Zhiwei 
Published: November 2023

Abstract
According to the structures traced by 13CO spectral lines within 12CO molecular clouds (MCs), we investigate the contributions of their internal gas motions and relative motions to the total velocity dispersions of 12CO MCs. Our samples of 2851 12CO MCs harbor a total of 9556 individual 13CO structures, among which 1848 MCs (∼65%) have one individual 13CO structure and the other 1003 MCs (∼35%) have multiple 13CO structures. We find that the contribution of the relative motion between 13CO structures (

σ

13

CO
,
re

) is larger than that from their internal gas motion (

σ

13

CO
,
in

) in ∼62% of 1003 MCs in the “Multiple” regime. In addition, we find that

σ

13

CO
,
re

tends to increase with the total velocity dispersion (

σ

12

CO
,
tot

) in our samples, especially for MCs with multiple 13CO structures. This result provides a manifestation of macroturbulence within MCs, which gradually becomes the dominant way of storing kinetic energy along with the development of MC scales.
SIMPLE: Simple Intensity Map Producer for Line Emission
Authors: Lujan Niemeyer Maja , Bernal José Luis , Komatsu Eiichiro 
Published: November 2023

Abstract
We present the Simple Intensity Map Producer for Line Emission (Simple), a public code for quickly simulating mock line-intensity maps, and an analytical framework for modeling intensity maps including observational effects. Simple can be applied to any spectral line sourced by galaxies. The Simple code is based on lognormal mock catalogs of galaxies including positions and velocities and assigns luminosities following the luminosity function. After applying a selection function to distinguish between detected and undetected galaxies, the code generates an intensity map, which can be modified with anisotropic smoothing, noise, a mask, and sky subtraction, and it calculates the power spectrum multipoles. We show that the intensity auto-power spectrum and the galaxy-intensity cross-power spectrum agree well with the analytical estimates in real space. We derive and show that the sky subtraction suppresses the intensity autopower spectrum and the cross-power spectrum on scales larger than the size of an individual observation. As an example application, we make forecasts for the sensitivity of an intensity mapping experiment similar to the Hobby–Eberly Telescope Dark Energy Experiment (HETDEX) to the cross-power spectrum of Lyα-emitting galaxies and the Lyα intensity. We predict that HETDEX will measure the galaxy-intensity cross-power spectrum with a high signal-to-noise ratio on scales of 0.04 h Mpc−1 < k < 1 h Mpc−1.
Accelerating Dedispersion Using Many-core Architectures
Authors: Novotný Jan , Adámek Karel , Clark M. A. , Giles Mike , Armour Wes 
Published: November 2023

Abstract
Astrophysical radio signals are excellent probes of extreme physical processes that emit them. However, to reach Earth, electromagnetic radiation passes through the ionized interstellar medium, introducing a frequency-dependent time delay (dispersion) to the emitted signal. Removing dispersion enables searches for transient signals like fast radio bursts or repeating signals from isolated pulsars or those in orbit around other compact objects. The sheer volume and high resolution of data that next-generation radio telescopes will produce require high-performance computing solutions and algorithms to be used in time-domain data-processing pipelines to extract scientifically valuable results in real time. This paper presents a state-of-the-art implementation of brute force incoherent dedispersion on NVIDIA graphics-processing units and on Intel and AMD central-processing units. We show that our implementation is 4× faster (8-bit 8192 channels input) than other available solutions, and we demonstrate, using 11 existing telescopes, that our implementation is at least 20× faster than real time. This work is part of the AstroAccelerate package.
L’inceste. Coûts et prix du lien conjugal
Authors: Jaïtin Rosa 
Published: November 2023

L’auteur présente une psychanalyse de couple qui a été soutenue par l’apport des « rêves étirés » (Bion), massifs et présymboliques. Les rêves ont permis au couple d’accéder à des traumatismes précoces. Leur abondance était le moyen de dénouer et de détoxifier les pactes dénégatifs autour de l’argent qui maintenaient le lien du couple dans un état d’agonie. Comme dans un roman à suspense, l’histoire du couple est révélée à travers les rêves en série montrant la complicité des partenaires. Pour contenir l’envahissement du champ transférentiel par les rêves, l’analyste différencie peu à peu des séquences où les signifiants de démarcation du contenu manifeste, produits en série, sont mis en relation avec le contenu latent : des traumatismes générationnels liés notamment à la rupture des contrats narcissiques, à la fortune acquise ou perdue, avec pour résultat des pensées en actes. Avec la présence du danger de mort et l’intervention de la loi, la souffrance peut se conflictualiser et les mécanismes défensifs s’assouplissent, permettant une différenciation rudimentaire entre fantasme et réalité.