bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview of Antihistamines and their Properties used for Treatment of
Different Diseases
Authors: Chaudhari Riya , Gosavi Seema , Bornare Pratiksha , Sonawane Saurabh , Ahire Tejas 
Published: November 2023

Background:
By comparing the histamine impact to the instant response to an injected foreign protein in previously sensitized animals, one might hypothesize that histamine may be involved in this reaction. Through all four of the recognized types of histamine receptors, histamine is also essential for the control of immunological function and acute and chronic allergic inflammation.

Methods:
Recent evidence points to anti-IgE antibodies and specific antibodies to cytokines like IL-4 or IL-5 that are associated with allergic inflammation as probable causes of Allergic Rhinitis. The therapeutic advantage of antihistamines is a decrease in allergy symptoms and any other allergy-related symptoms. We research the many diseases and dose forms in which antihistamines are used. Pediatric age groups have never been thoroughly studied for first-generation antihistamines. Oral antihistamines are suggested as the first line of therapy for people with mild to severe intermittent Allergic Rhinitis symptoms.

Results:
Currently, approximately 100 different antihistamine-containing medicines and
around 20 different H1-receptor antagonists are available for therapeutic use. Antihistamines
of the second generation are more efficient and secure than those of the first generation. We
conducted a research on the sedative and non-sedative effects of antihistamines used to treat
various diseases.

Conclusion:
The present investigation highlights the use of antihistamines in various diseases at different ages, their sedative and non-sedative effect, and their utility in treating insomnia based on their safety and current use among the patient population, as well as our observation.
Evaluation of the Capparis Herbacea Willd's Chemistry, Antioxidant and Cytotoxic Activity
Authors: Tleuberlina Orynbassar , Mamurova Asem , Iskakova Zhanar , Aibuldinov Yelaman , Kolpek Ainagul , Kopishev Yeldar , Satbaeva Gulbarshyn , Mukazhanova Zhazira , Kurmanbayeva Meruyert 
Published: November 2023

Background::
The Capparidaceae family includes the medicinal herb Capparis her-bacea Willd. The aerial and underground parts of plant C.herbacea were studied for their chemical composition, antioxidant, and cytotoxic properties

Methods:
Using gas chromatography with mass spectrometric detection (7890A/5975C), 94 chemicals were identified in ethanol extract from leaves, roots, seeds, and stems of C. her-bacea. Main components were (leaves) phytol 18.16%, hexanedioic acid, bis(2-ethylhexyl) ester 16.75%, vitamin E 11.95%, (roots) sucrose 13.94%, hexadecanoic acid, ethylester 22.80%, octadecanoic acid, ethylester 37.77%; (seeds) hexadecanoic acid, ethylester 13.96%, ethyl9.cis.,11.trans.-octadecadienoate 48.54%, bis(2-ethylhexyl) phthalate 9.77%; (stems) 1-propene-1,2,3-tricarboxylic acid, tributyl ester 42.69%, and tributylacetylcitrate 19.63%. Nine components were identified in the makeup of the C. herbacea sample's essential oil using the method of chromatography-mass spectrometry.

Results::
The main components were (in%): T-cadinol (29.56), meta-cymene (16.12), pulegone (14.11), and σ-amorphene (12.26). Chloroform and methanol extracts of Capparis herbacia roots at concentrations of 1 mg/ml showed higher average antioxidant activity, while ethyl acetate root extract at concentrations of 0.75 and 1 mg/ml showed higher average antioxidant activity compared to gallic acid AOA.

Conclusion::
In addition, plant extracts have cytotoxic activity. Essential oils of leaves and stems, fruit and roots of Capparis herbacia plants exhibited cytotoxicity, all larvae died, and larval mortality was 96%.
Unraveling the Impact of Pre-analytical and Analytical Factors on the
Quality of Biological Evidence: A Comprehensive Systematic Review
Authors: Prajapati Suneel , Mishra Aditi , Sapkota Megha , Meshram Mukul , Sharma Mahima , Kumar Arun 
Published: November 2023

Background::
Ensuring the quality of biological evidence is key and has become a
routine requirement in forensic laboratories. The quality of biological evidence is determined by
the pre-analytical and analytical phase that encompasses all procedures, starting with the crime
scene to laboratory investigation of biological evidence. This is the most vulnerable part of the
total testing process and a major component of the reliability and validity of results. Therefore,
to generate a quality report, every biological evidence resource should be collected, maintained,
and disseminated to the highest quality, based on the intended forensic use.

Methods::
Pre-analytical errors can happen at any stage prior to the testing process due to the use
of insufficient or improper order of evidence collection, packaging, labelling, prolonged environmental
exposure, failure to find the proper storage, the collection of evidence that is unsuitable
for quality or quantity, inappropriate mixing of a sample, etc. Such circumstances during transportation,
preparation, and storage can change the outcome of forensic evidence. While analytical
errors may arise in the laboratory during the processing of evidence due to mishandling, crosscontamination,
and a lack of standardised procedures.

Result::
Thus, employing advanced analytical methodologies, strict quality control measures, ad-herence to ethical guidelines, and appropriate data interpretation during PCR, STR profiling, and DNA sequencing are of utmost importance. The validation of quality assurance in forensic biol-ogy has been guided by a "fit-for-purpose" approach, emphasizing the suitability of methods and procedures for forensic requirements and intended applications. Pre-analytical and analytical fac-tors play a critical role in determining the success of DNA analysis and its admissibility in a court of law.

Conclusion::
To address this, this review aimed at summarizing recommendations about the pre-analytical and analytical phases and provides some guidance to reduce the effects of such factors that can have a significant impact on biological evidence.
Tooth Extraction using Vertical, Conventional, and Surgical Techniques in Sebha Dental College: A Descriptive “Cross-sectional Study”
Authors: Mohamed Ahmed Glewan , Ibrahim Abdulsalam E.E. , Abdusalam A. Milad Milad 
Published: November 2023

Objective:
This study aimed to describe different techniques (vertical, conventional, and surgical) used in routine exodontia as well as the most teeth extracted per procedure.

Methods:
A descriptive cross-sectional study using data collected at the Department of Oral Maxillofacial Surgery, the Faculty of Dentistry, Sebha University, from March to December 2021, included 509 participants. The patient's age and gender, techniques of extraction, and tooth type were recorded.

Results:
The study included 509 participants aged 16 to 90. About 38.1% of the participants were male, and 61.9% were female. The conventional technique was the most performed (70.0%), followed by vertical (elevator) (26%), and then the surgical technique. The third molar was the most common tooth extracted by conventional technique. The vertical approach was the most successful for single and multirooted teeth.

Conclusion:
The result of this study suggests that the vertical extraction method may be used with a high success rate for the extraction of teeth unsuitable for conventional techniques. Therefore, the effectiveness of the exodontia technique is influenced by root morphology, position, and type of tooth.
Evaluating Messaging on Prenatal Health Behaviors Using Social Media Data: Systematic Review
Authors: Frennesson Nessie Felicia , McQuire Cheryl , Aijaz Khan Saher , Barnett Julie , Zuccolo Luisa 
Published: November 2023

Background
Social media platforms are increasingly being used to disseminate messages about prenatal health. However, to date, we lack a systematic assessment of how to evaluate the impact of official prenatal health messaging and campaigns using social media data.

Objective
This study aims to review both the published and gray literature on how official prenatal health messaging and campaigns have been evaluated to date in terms of impact, acceptability, effectiveness, and unintended consequences, using social media data.

Methods
A total of 6 electronic databases were searched and supplemented with the hand-searching of reference lists. Both published and gray literature were eligible for review. Data were analyzed using content analysis for descriptive data and a thematic synthesis approach to summarize qualitative evidence. A quality appraisal tool, designed especially for use with social media data, was used to assess the quality of the included articles.

Results
A total of 11 studies were eligible for the review. The results showed that the most common prenatal health behavior targeted was alcohol consumption, and Facebook was the most commonly used source of social media data. The majority (n=6) of articles used social media data for descriptive purposes only. The results also showed that there was a lack of evaluation of the effectiveness, acceptability, and unintended consequences of the prenatal health message or campaign.

Conclusions
Social media is a widely used and potentially valuable resource for communicating and evaluating prenatal health messaging. However, this review suggests that there is a need to develop and adopt sound methodology on how to evaluate prenatal health messaging using social media data, for the benefit of future research and to inform public health practice.
Embodied Conversational Agents for Chronic Diseases: Scoping Review
Authors: Jiang Zhili , Huang Xiting , Wang Zhiqian , Liu Yang , Huang Lihua , Luo Xiaolin 
Published: November 2023

Background
Embodied conversational agents (ECAs) are computer-generated animated humanlike characters that interact with users through verbal and nonverbal behavioral cues. They are increasingly used in a range of fields, including health care.

Objective
This scoping review aims to identify the current practice in the development and evaluation of ECAs for chronic diseases.

Methods
We applied a methodological framework in this review. A total of 6 databases (ie, PubMed, Embase, CINAHL, ACM Digital Library, IEEE Xplore Digital Library, and Web of Science) were searched using a combination of terms related to ECAs and health in October 2023. Two independent reviewers selected the studies and extracted the data. This review followed the PRISMA-ScR (Preferred Reporting Items of Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) statement.

Results
The literature search found 6332 papers, of which 36 (0.57%) met the inclusion criteria. Among the 36 studies, 27 (75%) originated from the United States, and 28 (78%) were published from 2020 onward. The reported ECAs covered a wide range of chronic diseases, with a focus on cancers, atrial fibrillation, and type 2 diabetes, primarily to promote screening and self-management. Most ECAs were depicted as middle-aged women based on screenshots and communicated with users through voice and nonverbal behavior. The most frequently reported evaluation outcomes were acceptability and effectiveness.

Conclusions
This scoping review provides valuable insights for technology developers and health care professionals regarding the development and implementation of ECAs. It emphasizes the importance of technological advances in the embodiment, personalized strategy, and communication modality and requires in-depth knowledge of user preferences regarding appearance, animation, and intervention content. Future studies should incorporate measures of cost, efficiency, and productivity to provide a comprehensive evaluation of the benefits of using ECAs in health care.
Medical Misinformation in Polish on the World Wide Web During the COVID-19 Pandemic Period: Infodemiology Study
Authors: Chlabicz Małgorzata , Nabożny Aleksandra , Koszelew Jolanta , Łaguna Wojciech , Szpakowicz Anna , Sowa Paweł , Budny Wojciech , Guziejko Katarzyna , Róg-Makal Magdalena , Pancewicz Sławomir , Kondrusik Maciej , Czupryna Piotr , Cudowska Beata , Lebensztejn Dariusz , Moniuszko-Malinowska Anna , Wierzbicki Adam , Kamiński Karol A 
Published: November 2023

Background
Although researchers extensively study the rapid generation and spread of misinformation about the novel coronavirus during the pandemic, numerous other health-related topics are contaminating the internet with misinformation that have not received as much attention.

Objective
This study aims to gauge the reach of the most popular medical content on the World Wide Web, extending beyond the confines of the pandemic. We conducted evaluations of subject matter and credibility for the years 2021 and 2022, following the principles of evidence-based medicine with assessments performed by experienced clinicians.

Methods
We used 274 keywords to conduct web page searches through the BuzzSumo Enterprise Application. These keywords were chosen based on medical topics derived from surveys administered to medical practitioners. The search parameters were confined to 2 distinct date ranges: (1) January 1, 2021, to December 31, 2021; (2) January 1, 2022, to December 31, 2022. Our searches were specifically limited to web pages in the Polish language and filtered by the specified date ranges. The analysis encompassed 161 web pages retrieved in 2021 and 105 retrieved in 2022. Each web page underwent scrutiny by a seasoned doctor to assess its credibility, aligning with evidence-based medicine standards. Furthermore, we gathered data on social media engagements associated with the web pages, considering platforms such as Facebook, Pinterest, Reddit, and Twitter.

Results
In 2022, the prevalence of unreliable information related to COVID-19 saw a noteworthy decline compared to 2021. Specifically, the percentage of noncredible web pages discussing COVID-19 and general vaccinations decreased from 57% (43/76) to 24% (6/25) and 42% (10/25) to 30% (3/10), respectively. However, during the same period, there was a considerable uptick in the dissemination of untrustworthy content on social media pertaining to other medical topics. The percentage of noncredible web pages covering cholesterol, statins, and cardiology rose from 11% (3/28) to 26% (9/35) and from 18% (5/28) to 26% (6/23), respectively.

Conclusions
Efforts undertaken during the COVID-19 pandemic to curb the dissemination of misinformation seem to have yielded positive results. Nevertheless, our analysis suggests that these interventions need to be consistently implemented across both established and emerging medical subjects. It appears that as interest in the pandemic waned, other topics gained prominence, essentially “filling the vacuum” and necessitating ongoing measures to address misinformation across a broader spectrum of health-related subjects.
Wear Experience with a Daily Disposable Soft Contact Lens for Astigmatism in Current Wearers of a Reusable Soft Toric Contact Lens
Authors: Fogt Jennifer Swingle , Satiani Nidhi , Patton Kimberly 
Published: November 2023

Objective: This study aimed to evaluate the wear experience of satisfied wearers of a particular reusabletoric soft contact lens when refit into a water surface technology daily disposable toric soft contact lens.
Methods: Thirty participants completed the study over three visits. At the first visit, subjects were refitted with their habitual reusable toric soft contact lens (comfilcon A) to maximize fit and vision. Subjects returned after one week and were then refit into the study daily disposable soft contact lenses (verofilcon A) and completed surveys of their initial impressions of comfort, vision, and satisfaction. Participants wore the study lenses for two weeks and then returned for their final visit to complete a vision and ocular health check. At the final visit, subjects also completed surveys to rate their overall and end-of-day comfort, quality of vision, stability of vision, and dryness using a visual analog scale (VAS). Participants also answered questions about their wear experience with the lenses. All data and surveys’ overall median and interquartile range (IQR) were calculated.
Results: Initial impressions of the study lenses revealed a median (IQR) score of 85 (28) for vision, 91 (25) for comfort, and 87 (21) for satisfaction. Overall VAS scores after two weeks of wear found median scores of 93 (16) for quality of vision, 88 (28) for stability of vision, and 91 (20) for comfort. End-of-day median scores were 82(27) for quality of vision, 90 (35) for stability of vision, and 80 (38) for comfort. Overall dryness scores were 20(45), and end-of-day dryness was 39 (46). Median(IQR) binocular logMAR visual acuity with the study lenses was -0.16(0.1). The median rotation of the lenses was 0(4.3) degrees.
Conclusion: Participants wearing the daily disposable study lenses for astigmatism gave high scores in vision and comfort at the initial fitting and after two weeks of lens wear. Results showed that satisfied wearers of comfilcon A reusable toric soft contact lenses can be successfully refitted with verofilcon A daily disposable contact lenses.
Post-cure Heat Treatments Influence the Mechanical and Optical Properties of Acrylic and Bis-acryl Composite Resins
Authors: Morgado LB , Pedrosa MS , Medeiros IS 
Published: November 2023

SUMMARY

Objective
To evaluate the influence of post-cure heat treatments (PCHT) on Knoop microhardness (KHN) and color change of bis-acryl composite resin (Protemp 4 - 3M ESPE, USA and PrimmaArt - FGM, Brazil) and chemically activated acrylic resins (Dencôr – Clássico, Brazil, and Duralay – Cotia, Brazil).

Methods and Materials
Specimens (12×1 mm) were prepared for each material (n=10/group). Thirty minutes after curing, the specimens were subjected to PCHT for 10 minutes at 70°, 100°, or 130°C. The control group was kept at room temperature (24°C) for the same amount of time. KHN was analyzed 24 hours after PCHT (n=10). Following Commission Internationale de l’Éclairage (CIE) Delta E 2000 (CIEDE2000 [ΔE00]), color measurements were obtained at three time points: 1. after polymerization; 2. after PCHT; and 3. after 30 days of storage in water, coffee, or red wine. Data for each material were analyzed by one-way analysis of variance (ANOVA) (p&lt;0.05).

Results
The PCHT at 130°C produced the highest KHN values. Except for the 70°C groups from Dencôr and Protemp, all PCHTs increased the initial color values (p&gt;0.05). In general, chemically activated acrylic resins showed an increase in color stability when subjected to PCHT (p&gt;0.05). For bis-acryl composite resin, PCHT did not influence color stability (p&lt;0.05).

Conclusion
Overall, the results showed that PCHT increased the tested materials’ color changes and Knoop microhardness. However, except for PCHT at 130°C in Duralay, the color changes remained within acceptable values. The PCHT treatment resulted in better color stability for most of the composite resins studied.
Case Management of Respiratory Failure in Pneumonia: Literature Review
Authors: Rohmah Dinda Nur 
Published: November 2023

Introduction: Respiratory failure is a frequent condition in critically ill patients that is associated with a high mortality rate, especially when invasive mechanical ventilation is required. In many case fever, cough, sputum and shortness of breath occur. Severe respiratory failure can lead to severe respiratory infections, such as lung infections (pneumonia).
Methoda: a literature review research method in the form of a case report through searches for accredited journal sites such as Sciendirect and Elsevier with the keywords respiratory failure in pneumonia in the 2015-2020 period.
Research result: in handling pneumonia cases, each country has its own way, consisting of physical examination, blood laboratory test, chest x-rays, chest CT scan, sputum culture examination, pxygen installation, mechanical ventilation and administration of drugs such as piperacillin-tazobactim, levlofoxacin, ceftriaxone, oseltamivir, azithromycin, each patient is deffernt based on the history of pain suffered.
Conclusion: each region and every country has its own way of dealing with pneumonia until now the disease is the most common cause of in out patient hospital clinics in various countries.
PENGELOLAAN KEUANGAN DAERAH DENGAN SISTEM TRANSAKSI NON TUNAI PADA BADAN PENGELOLAAN KEUANGAN DAN PENDAPATAN DAERAH (BPKPD) KOTA TEBING TINGGI (Studi pada Pelaksanaan Penerimaan Keuangan Daerah)
Authors: Sitinjak Tania Meylina , Candradewini Candradewini , Munanjat Mas Dadang Enjat 
Published: November 2023

Penelitian ini dilatarbelakangi oleh adanya upaya pemerintah Kota Tebing Tinggi dalam menerapkan sistem transaksi non tunai dalam pengelolaan keuangan daerahnya. Penelitian ini dibatasi pada pelaksanaan penerimaan keuangan daerah dengan pertimbangan bahwa walaupun penerimaan pajak daerah pada BPKPD Kota Tebing Tinggi sudah menerapkan sistem transaksi non tunai secara keseluruhan namun pada penerapannya belum terlaksana secara optimal. Sehingga penelitian ini bertujuan untuk mengetahui bagaimana pengelolaan keuangan daerah dengan sistem transaksi non tunai pada Badan Pengelolaan Keuangan dan Pendapatan Daerah (BPKPD) Kota Tebing Tinggi. Teori yang digunakan dalam penelitian ini adalah teori pengelolaan keuangan daerah yang didasarkan pada 5 (lima) prinsip utama dalam pengelolaan keuangan daerah menurut Chabib dan Heru (2010:10). Metode penelitian yang digunakan adalah kualitatif deskriptif dan menggunakan teknik pengumpulan data yaitu wawancara, observasi, dokumentasi, dan studi kepustakaan.Hasil penelitian ini menunjukkan bahwa pengelolaan keuangan dengan sistem transaksi non tunai pada BPKPD Kota Tebing Tinggi seluruh aliran dananya dapat ditelusuri, pencatatan transaksi sudah secara langsung dan adanya bukti pertanggungjawaban yang lengkap yang mana dapat mewujudkan tertib administrasi pengelolaan keuangan daerah. Dengan menggunakan transaksi non tunai, setiap transaksi terekam dalam bukti transaksi perbankan sehingga setiap penerimaan pajak daerah dapat diketahui secara real time oleh BPKPD Kota Tebing Tinggi. Sehingga pelaksanaan transaksi non tunai berdampak pada jumlah penerimaan pajak daerah yang cenderung meningkat dari tahun 2018-2021.