bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradigm Shift in World Health Organization Classification of Odontogenic Tumors - a 12 Years of Institutional Experience
Authors: yadav jagveer , Narwal Anjali , Kamboj Mala , Devi Anju , sharma Gitika , Vijayakumar Gopikrishnan 
Published: February 2024

Abstract
Introduction:
Due to a lack of consistent international identification standards, the classification of odontogenic tumors (OTs) has undergone various modifications over the years. Their prevalence and frequency distribution were significantly altered as a result of this reclassification.
AIM
The purpose of this study was to highlight the effect of shifting classification systems on the prevalence and relative frequency of odontogenic tumors. The secondary goal was to compare the demographics of distinct histological categories of odontogenic tumors to published literature.
Methods
This was hospital-based retrospective research that obtained case data on odontogenic tumors diagnosed between 2010 and 2022. The categorization was based on the 2005, 2017, and 2022 World Health Organization (WHO) classifications and the prevalence and frequency distribution of odontogenic tumors using the WHO 2005, 2017, and 2022 classifications.
Results
From 2010 to 2022, a total of 226,145 and 149 cases of odontogenic tumors were detected using the 2005, 2017, and 2022 WHO categorization methods.
Conclusions
The variability in odontogenic tumors might be attributed in part to continually evolving classification systems. Variations in the relative incidence of different histological kinds of odontogenic tumors may represent varied populations with varying genetic and environmental variables.
Extracellular vesicles containing anti-miR-128-3p derived from mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by suppressing neuronal pyroptosis and modulating microglia polarization
Authors: Zhou Xinyu , Zhou Hang , Xu Liaoyang , Wu Huijuan , Zhou Xiaomei , Ren Xiaolin , Li Xiaomin 
Published: February 2024

Abstract
Cerebral ischemia-reperfusion (CI/R) injury seriously threatens the patients with ischemic stroke. MiR-128-3p level was found to be upregulated in serum samples of patients with ischemic stroke. It has been shown that miRNA in extracellular vesicles (specifically exosomes) has attracted attention because mesenchymal stem cells (MSCs)-derived exosomes play a favorable role in improving CI/R injury. Thus, we investigated whether MSCs-derived exosomes can be used to deliver miR-128-3p inhibitor (anti-miR-128-3p) to treat CI/R injury. BV2 cells were exposed to oxygen-glucose deprivation/reperfusion (OGD/R) for constructing in vitro model of CI/R. In addition, a rat model of middle cerebral artery occlusion (MCAO) was established to construct in vivo model of CI/R. Results indicated that miR-128-3p inhibitor can be transferred from MSCs to BV2 cells via exosomes. MSCs-derived exosomes containing anti-miR-128-3p significantly reduced the viability and inflammatory response in OGD/R-treated BV2 cells. Additionally, exosomes containing anti-miR-128-3p was able to enhance M1-to-M2 polarization of BV2 cells exposed to OGD/R. Meanwhile, exosomal anti-miR-128-3p markedly decreased infarct area in MCAO rats. Furthermore, NRBF2 was a direct target of miR-128-3p. Exosomal anti-miR-128-3p obviously reduced the level of NRBF2 downstream genes including NLRP3 and Caspase 1 in OGD/R-treated BV2 cells as well as in brain tissues of MCAO rats, suggesting that MSCs-derived exosomal anti-miR-128-3p could attenuate neural cell pyroptosis. In conclusion, exosomes containing anti-miR-128-3p derived from MSCs could attenuate CI/R injury via suppressing neuronal pyroptosis and modulating microglia polarization. Hence, our study might provide a theoretical basis for the treatment of ischemic stroke.
Emerging Concerns for air pollutants from chemical laboratories: Emission Characteristics, Diffusion Effects, and Ozone Formation Potential
Authors: Wang Chenlong , Yue Tao , Wang Kun , Zuo Penglai , Gao Jiajia , Liang Quanming , Zhang Yun , Tong Yali , Tong Li , Han Yue , Zhang Xiaoxi , Li Bingyang , Guo Zhanqiang , Liu Cuiling 
Published: February 2024

Abstract
Although laboratories play a key role in scientific research at academic institutions, they pose an environmental threat because they discharge pollutants to the atmosphere. Typically, when laboratory experiments are conducted, harmful gases are generated, which pose a safety hazard. To ensure safe operation in laboratories, fume hoods or gas collection hoods are used to collect toxic and harmful pollutants and expel them through ventilation ducts. However, these pollutants lead to a series of environmental problems. According to preliminary tests, these pollutants primarily contain volatile organic compounds, such as esters, aromatic compounds, and polycyclic aromatic hydrocarbons, which are resistant to degradation. In this study, long-term and periodic field monitoring was conducted to measure the concentrations and determine the chemical composition spectra of air pollutants discharged by three typical chemical laboratories located in Beijing, China. The results revealed 47 stable atmospheric pollutants exceeding the detection limit. Although the concentrations of these pollutants were characterized by an intermittent low peak and a low mean value, they were observed only for a short duration, and they tended to normalize after approximately 10 min. In summary, limiting the concentration of highly active substances is regarded as a key mechanism of air pollutant control in chemical laboratories. Overall, this study provides insights into the prevention and control of air pollutant discharge by chemical laboratories in academic institutions.
Design, Synthesis and Antiviral Activity of Indole Derivatives Containing Quinoline Moiety
Authors: He Bangcan , Hu Yuzhi , Qin Yishan , Zhang Yufang , Luo Xingping , Wang Zhenchao , Xue Wei 
Published: February 2024

Abstract

A series of indole derivatives containing quinoline structure were designed and synthesized. The synthesized compounds were characterized by NMR and HRMS. And W14 was performed by single crystal X-ray diffraction experiments. The antiviral activity studies showed that some of the target compounds possessed significant activity against tobacco mosaic virus (TMV). In particular, W20 had significant activity. The results of in vivo anti-TMV activity assay showed that W20 possessed the best curative and protective activities with EC50 values of 84.4 and 65.7 µg/mL, which were better than ningnanmycin (NNM) 205.1 and 162.0 µg/mL, respectively. The results of Microscale thermophoresis (MST) showed that W20 had a strong binding affinity for the tobacco mosaic virus coat protein (TMV-CP) with a dissociation constant (Kd) of 0.00519 µmol/L, which was superior to that of NNM (1. 65320 µmol/L). The molecular docking studies were accordance with the experimental results. In addition, the determination of malondialdehyde (MDA) content in tobacco leaves showed that W20 improved the disease resistance of tobacco. Overall, this study shows that indole derivatives containing quinoline can be used as new antiviral agents for plant viruses for further research.
Mandatory Minute Ventilation (MMV) as a rescue mode of ventilation in late preterm and term infants
Authors: Bose Adrita , Sk Md Habibullah , Saha Bijan 
Published: February 2024

Abstract
Mandatory Minute Ventilation (MMV) is a valuable rescue mode for late preterm and term infants experiencing challenges with hyperventilation. In this prospective study, seven infants were ventilated using MMV as a rescue mode. Infants initially under Pressure Control-Assist/Control with Volume Guarantee (PC-AC + VG) mode were transitioned to Pressure Control-MMV (PC-MMV) using Drager Babylog VN 600. All infants were late preterm or term, without major congenital malformations. Our findings suggest that transitioning to PC-MMV resulted in improved gas exchange stability, reduced respiratory rate, and facilitated early weaning. The study's strengths include prospective data collection and a uniform cohort. However, limitations include the exclusive focus on late preterm and term infants and the lack of exploration of clinical or long-term outcomes. The use of MMV as a rescue mode in these infants warrants further investigation in future clinical studies.
Conclusion: MMV offers a promising approach for managing hyperventilation with increase work of breathing as a rescue mode in late preterm and term infants. Further research is needed to establish the efficacy and long-term outcomes of MMV in neonatal care.
Adolescent boys’ experiences of stress – a focus group study
Authors: Schmidt Manuela , Hansson Erika 
Published: February 2024

Abstract

Background: The number of adolescents reporting that they are stressed has more than doubled among both boys and girls. Most focus is usually given to girls because they typically report not only higher levels of stress but also feel stressed more frequently than do boys. However, studies have confirmed that boys’ experience of stressors was the same, implying that the genders are equally prone to experiencing stress. Although male and female adolescents appear to experience stress in a similar way, how they cope with these stressors might differ. This study focuses on boys’ experiences of stress and how they cope with it.
Method: Eight focus groups were conducted with 39 adolescent boys aged 12–19 years enrolled in four schools in southern Sweden. The data was analysed inductively with conventional content analysis.
Results: The analysis resulted in three categories: Stress perception – time as a key factor, Identifying stressors and levels of stress, and Silent struggles and distractions. The boys had experienced considerable stress in their lives, despite their limited understanding of the concept. Their coping skills were limited to engaging in sports or distracting themselves from the stressors while social support from peers, school staff, or family was generally discarded.
Conclusions: Adolescent boys might need assistance in identifying stress and clearly voicing their specific concerns. They should also be provided with spaces that are free from stigmatization and judgement. Parents, teachers, and school nurses should be equipped with the appropriate tools and education on how to discuss stress and mental health in general with adolescent boys to prevent possible negative long-term consequences for both their physical and mental health.
Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis in prenatal care in the public health system, in a southern city of Brazil
Authors: Traesel Danielle Betina de Oliveira , de Carvalho Newton Sérgio , Bicalho Maria da Graça , Gaspar Pamela Cristina , Bazzo Maria Luiza , Miranda Angélica Espinosa Barbosa 
Published: February 2024

Abstract
Sexually transmitted infections (STI) are prevalent in developing countries and are associated with unfavorable perinatal outcomes. Infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG) and Trichomonas vaginalis (TV) are asymptomatic in 70% of cases. The objective of this study is to determine the prevalence of CT, NG, MG and TV in pregnant women, correlating it with sociodemographic data.
The sample had 148 pregnant women between 18 and 49 years old, who attended in Joinville, South Brazil, from November 2021 to March 2022. The exclusion criteria were: recent antibiotic therapy and risk for miscarriage. Data collection and endovaginal swabs were performed to research of agents through molecular biology.
148 pregnant women were studied, 16.2% (N=24) had at least one of the agents positive. C. trachomatis , M. genitalium and T. vaginalis were detected in 11 (7.43%), 13 (8.78%) and 3 (2.03%) women, respectively. N. gonorrhoeae was not detected. There were three cases of infection with more than one microorganism (2 CT + MG and 1 MG + TV). MG infection was associated with single women (p-value=0.014); trichomoniasis, with more partners in the last year (p-value=0.042).
The high detection of MG in Brazilian pregnant women deserves to be highlighted. This had not yet been reported. The prevalence of CT and NG was in accordance to Brazilian studies, while TV was in common with European rates. The absence of clinical symptoms, the non-association between sexual risk behavior and the presence of STI were observed.
Determining The Levels Concentrations of the Two Toxic Elements Cadmium and Lead in the Serum Thalassemia Patients for Citizens of Najaf Governorate, Iraq
Authors: Abdulrudha Noor Hassan , Kadhim Shaymaa Awad 
Published: February 2024

Abstract

Thalassemia is a class of hereditary hematologic illnesses resulting from abnormalities in the production of one or more hemoglobin chains. Patients with β-thalassemia may have a reduction in heavy metal levels as a result of iron chelate medication. the aim Study the levels of heavy metals (toxic) in the blood of beta-thalassemia patients and compare them to healthy people for the purpose of arriving at indicators through which it is possible to assist in early diagnosis of this disease or reduce symptoms. The study included 80 patients in comparison with age and gender-matched 40 healthy individuals as controls. Samples were gathered between July 1, 2023, and September 1, 2023. The patients were interviewed for socio-demographic variables, and their medical histories were obtained from the hospital files. Cadmium and lead concentrations were determined using flame atomic absorption spectrometry (FAAS). Cadmium levels in thalassemia patients were found to be lower in both genders than in the control group. Lead levels were found to be greater in male thalassemia patients and lower in female thalassemia patients than those in the control group of female thalassemia patients. Additionally, it was observed that patients from areas outside of Najaf's city center had greater levels of lead and cadmium than patients from the city center. Cadmium and lead levels in the serum were often low in thalassemia patients. Heavy metals are eliminated when deferasirox chelate is taken.
Non-Linear Time Series Analysis of Upper Limb Exercise Kinematics Profile
Authors: Chakraborty Pritam , Neogi Biswarup , Das Achintya , Faheem Muhammad , Bose Rajesh , Khan Arfat Ahmad , Roy Sandip 
Published: February 2024

Abstract
This research investigates the kinematic characteristics of shoulder and scapula movement during the Arnold press exercise, focusing on the joints of interest including the acromion (l-ai), lateral tip of the scapula (l-ts), C7 vertebra, and T8 vertebra. Using motion capture technology, three-dimensional coordinates of these anatomical landmarks were recorded to capture the dynamic motion patterns. State space reconstruction was performed with optimized embedding dimensions determined to be 7 for l-ai, 8 for l-ts, and 1 for both C7 and T8. Recur- rence Quantification Analysis (RQA) was employed to analyze the recurrence properties of the reconstructed state space, revealing %recurrence rate values of 0.8933 for l-ai, 0.2358 for l-ts, 1.2973 for C7, and 1.2916 for T8.Additionally, recur- rence entropy values were computed to be 20.17 for l-ai, 26.18 for l-ts, 26.44 for C7, and 26.30 for T8, indicating the level of predictability and complexity in the motion patterns. Furthermore, Lyapunov exponents were calculated to assess the system’s sensitivity to initial conditions, with values of 0.3724 for l-ai, -0.3230 for C7, 0.2904 for T8, and 0.27 for l-ts. These findings provide valuable insights into the dynamic behavior and coordination of shoulder and scapula movement during the Arnold press exercise, with implications for optimizing exercise performance and injury prevention strategies.
GM130-silencing May Aggravate Blood-brain barrier Damage and Affect Microglia Polarization by Down-regulating PD-L1 Expression after Experimental Intracerebral Hemorrhage
Authors: Chen Xiqian , Ren Yijun , Xie Pinghui , Lei Qiang , Lu Wei 
Published: February 2024

Abstract

Background: In addition to primary injury, secondary injuries related to BBB disruption and immune-inflammatory response also play an important role in Intracerebral hemorrhage (ICH).And the Golgi apparatus play an important role in the state of ICH.
Methods: ICH model and GM130-silencing ICH model were established in SD rats. The Garcia score was used to score the neurological defects of the rats. Blood- brain barrier (BBB) integrity were assessed by amount of extravasated Evans blue, and tight junction proteins. The expression of PD-L1 and GM130were detected through Western-blot and the subtype of microglia was showing with Immunofluorescence staining.
Results: Compared with the ICH group, GM130-silencing ICH rats got a worsened neurological deficit and enlarged volume ofthe hematoma. Evan’s blue extravasation aggravated as well. The expression of GM130 in peri-hematoma tissue was further decreased, and the morphology and structure of the Golgi apparatus were further damaged. Meanwhile, the GM130 deficit resulted in decreased expression of PD-L1 and more polarization of microglia to the M1 subtype.
Conclusion:We demonstrate that GM130 could influence the integrity of BBB and plays a role in neuroinflammation via regulation of PD-L1 after ICH. The manipulation of GM130 might be a promising therapeutical target in ICH.
Association of Improvement and Worsening of Depressive Symptoms with Arthritis
Authors: Liu Ruxi , Xin Yinuo , Shao Yining , Wu Bo , Liu Yan 
Published: February 2024

Abstract
Purpose
The longitudinal association between changes in depressive symptoms (improvement/worsening) and arthritis is unclear.
Methods
The 10-item Center for Epidemiological Studies Depression Scale (CES-D-10) was used to examine participant depressive symptoms and data on self-reported history of arthritis were collected. Depressive symptoms improving is defined as depression at baseline and no depression at follow-up. Similarly, depressive symptoms worsening is defined as no depression at baseline and depression at follow-up. Cox proportional hazards models were used to evaluate the effects of improvement or deterioration in depressive symptoms on arthritis.
Results
A total of 8556 participants free of arthritis were included from 2011 to 2018. After adjustment for confounders, depressive symptoms were associated with a 54% increased risk of developing arthritis. Each 1-point increase in CES-D-10 score was associated with a 4% higher risk of arthritis. Participants with depressive symptoms at baseline but improved symptoms (without depressive symptoms) at follow-up had a 25% lower rate of arthritis, and a 1-point reduction in CES-D-10 score during 8 years of follow-up was associated with a 5% lower risk of developing arthritis. Participants with no depressive symptoms at baseline but depression at follow-up had a 66% higher rate of arthritis, and a 1-point increase in CES-D-10 score during 8 years of follow-up was associated with a 5% higher risk of arthritis.
Conclusions
Improvement in depressive symptoms was associated with lower risk of arthritis and worsening of depression was associated with higher risk of arthritis. These findings suggest that the relationship between depression and arthritis is complex.
A Novel Hybrid Beamforming Algorithm for Massive MIMO LEO Satellite Communication
Authors: Mahmood Anas L. , Mohammed Yaseen A. 
Published: February 2024

Abstract
Despite there are many hybrid beamforming architectures and algorithms for multiuser Massive Multiple Input Multiple Output (MIMO) system in terrestrial networks, it is still in the initial stages for non-terrestrial networks. This research studies the system model of multiuser MIMO system for Satellite communications, investigates the channel model, and formulates the problem of hybrid beamforming. In essence, it proposes a novel hybrid beamforming algorithm designed for multiuser Massive MIMO systems. The proposed algorithm shows a significant gain in spectral efficiency and a considerable decrease in computation time. Moreover, the proposed algorithm maintains a similar spectral efficiency to continuous phase algorithms but reduces costs by using discrete phase shifters for the Radio Frequency (RF) chains rather than continuous counterparts. Numerical experiments exhibit the efficacy of our novel algorithm, surpassing recent algorithms in the field. Since our algorithm is compared with algorithms used for terrestrial communications and it is not restricted to LEO channel model, it can be applied for terrestrial and non-terrestrial communications.
Exploring Mathematical Models and Algorithms for Plagiarism Detection in Text Documents: A Proof of Concept
Authors: Ahmed Tanvir 
Published: February 2024

Abstract
The aim of this article is to explore the literature and develop a proof of concept application for detecting plagiarism in text documents. Plagiarism has become a crucial research area in recent years as various research, publishing, and teaching institutions seek to drastically eliminate the reinvention of the wheel associated with many research studies. People have wondered about how to check a suspected document against millions of reference documents to find an instance of plagiarism. This study focuses on providing the audience with the necessary information about mathematical models for texts, text processing, similarity measures, algorithms, and data structures for detecting plagiarism in text documents based on the type of texts.
Compressibility, thermal expansion, and Raman spectroscopy of synthetic whitlockite Ca9Mg(PO3OH)(PO4)6 at high pressures and high temperatures
Authors: Jia Muhua , Liu Yungui , Jiang Sheng , Wen Wen , Zhai Shuangmeng 
Published: February 2024

Abstract
In situ X-ray diffraction and Raman spectroscopy of a synthetic whitlockite, Ca9Mg(PO3OH) (PO4)6, have been conducted at high pressures or high temperatures. The results show that whitlockite is stable up to ~15 GPa at ambient temperature and undergoes a thermally induced dehydrogenation to merrillite above 973 K at ambient pressure. The obtained pressure-volume data were fitted using a third-order Birch-Murnaghan equation of state, yielding an isothermal bulk modulus of K0 = 79(4) GPa with a pressure derivative of K0′ = 4.3(6). When K0′ was fixed at 4, the refined isothermal bulk modulus was 81(1) GPa. The volumetric thermal expansion coefficient (αV) is 4.05(8) × 10–5 K–1, and the axial thermal expansion coefficients (αa and αc) are 1.07(5) × 10–5 K–1 and 1.91(6) × 10–5 K–1. Both compressibility and thermal expansion show an axial anisotropy. The effects of pressure and temperature on the Raman spectra of whitlockite have been quantitatively analyzed. The isothermal and isobaric mode Grüneisen parameters and the intrinsic anharmonic mode parameters of whitlockite were derived. Some amounts of OH–-bearing whitlockite may be preserved in meteorites if whitlockite undergoes a low-temperature process.