bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Some New Chiral Bifunctional o‐Hydroxyarylphosphonodiamides and Their Application as Ligands in Ti(IV) Complex Catalyzed Asymmetric Silylcyanation of Aromatic Aldehydes.
Authors: He Ke , Zhou Zhenghong , Wang Lixin , Li Kangying , Zhao Guofeng , Zhou Qilin , Tang Chuchi 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Alkatrienyl Sulfoxides and Sulfones. Part 5. Tandem Cyclization, Rearrangement, and Aromatization of 1‐ and 3‐Vinylallenyl Sulfoxides and Sulfones in Diels—Alder Reaction.
Authors: Christov Valerij Ch. , Ivanov Ivaylo K. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Facile Acid‐Catalyzed Condensation of 2‐Hydroxy‐2,2′‐biindan‐1,1′,3,3′‐tetrone with Phenols, Methoxyaromatic Systems and Enols.
Authors: Das Suven , Pramanik Animesh , Froehlich Roland , Patra Amarendra 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
s‐Indacene‐1,3,5,7(2H,6H)‐tetraone (“Janus Dione”) and 1,3‐Dioxo‐5,6‐indanedicarboxylic Acid: Old and New 1,3‐Indandione Derivatives.
Authors: Krief Pnina , Becker James Y. , Ellern Arkady , Khodorkovsky Vladimir , Neilands Ojars , Shapiro Lev 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diels—Alder Reactions with Cyclic Sulfones. Part 7. Synthesis of 1‐Benzothiophene 1,1‐Dioxide Derivatives.
Authors: Andreev G. N. , Shul'ts E. E. , Volkov A. A. , Shakirov M. M. , Bagryanskaya I. Yu. , Gatilov Yu. V. , Tolstikov G. A. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
N‐Alkylation of N‐(2,5‐Dioxopyrrolidin‐1‐yl)benzamides.
Authors: Kolobov A. V. , Panfilov S. T. , Borisov P. V. , Ovchinnikov K. L. , Khokhlev A. L. , Danilova A. S. , Kofanov E. R. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterocyclic Thiones and Their Analogues in 1,3‐Dipolar Cycloaddition Reactions. Part 2. Reactions of Benzothiazole‐2‐thione with Nitrilimines.
Authors: Firsova O. V. , Dolgushina T. S. , Polukeev V. A. , Zavodnik V. E. , Stash A. I. , Bel'skii V. K. , Galishev V. A. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
β‐Oxosulfone Thiosemicarbazones in the Synthesis of S,N‐Containing Heterocycles.
Authors: Gerasimova N. P. , Ermolaeva V. V. , Nozhnin N. A. , Alov E. M. , Moskvichev Yu. A. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Versatile Approach to 6‐Substituted‐5‐methoxy‐δ‐lactam Framework and Application to the Formal Synthesis of (.+‐.)‐Homopumiliotoxin 223G.
Authors: Chen Bo‐Fong , Tasi Min‐Ruei , Yang Cheng‐Yu , Chang Jung‐Kai , Chang Nein‐Chen 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Synthetic Method for an Indolizidine Skeleton by C—N Bond Formation via a π‐Allylpalladium Complex.
Authors: Yamada Yaeko , Takahashi Wakako , Asada Yoshihisa , Holiuchi Junko , Takeda Kazuyoshi , Harigaya Yoshihiro 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ring Transformation of 7‐Nitro‐1‐(4‐nitrophenyl)‐4,5‐dihydro‐1H‐imidazo‐ and ‐[1,2,3]triazolo[4,5‐c]pyridin‐4‐ones.
Authors: Yutilov Yu. M. , Smolyar N. N. , Eres'ko A. B. , Gres'ko S. V. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chemistry of Diazopolycarbonyl Compounds. Part 9. Synthesis of 6‐Aryl‐3‐acyl‐4‐hydroxypyridazines by Heterocyclization of 1,5‐Disubstituted 2‐Diazo‐1,3,5‐pentanetriones.
Authors: Kutkovaya N. V. , Pulina N. A. , Zalesov V. V. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterocyclic Analogues of Pleiadiene. Part 74. peri‐Cyclizations in the Perimidine Series. Synthesis of 1,3‐Diazapyrene Derivatives.
Authors: Borovlev I. V. , Demidov O. P. , Aksenov A. V. , Pozharskii A. F. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Direct Diastereoselective Introduction of l‐Menthol Residue into 1,2,4‐Triazin‐5(4H)‐one.
Authors: Zyryanov G. V. , Rusinov V. L. , Chupakhin O. N. , Krasnov V. P. , Levit G. L. , Kodess M. I. , Shtukina T. S. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chloromethyl‐, Dichloromethyl‐, and Trichloromethyl‐1,2,4‐triazines and Their 4‐Oxides: Method for the Synthesis and tele‐Substitution Reactions with C‐Nucleophiles.
Authors: Kozhevnikov D. N. , Kataeva N. N. , Rusinov V. L. , Chupakhin O. N. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Atom‐Economic Synthesis of Tertiary 2‐Alkoxyethylphosphine Sulfides.
Authors: Gusarova Nina K. , Ivanova Nina I. , Bogdanova Maria V. , Malysheva Svetlana F. , Belogorlova Nataliya A. , Sukhov Boris G. , Trofimov Boris A. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterization of 2‐Iminoperhydro‐1,3‐selenazin‐4‐ones by Reaction of N,N′‐Disubstituted Selenoureas with Acryloyl Chloride.
Authors: Koketsu Mamoru , Taura Masayasu , Ishihara Hideharu 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Effect of π‐Accepting Substituent on the Reactivity and Spectroscopic Characteristics of Triarylbismuthanes and Triarylbismuth Dihalides.
Authors: Rahman A. F. M. Mustafizur , Murafuji Toshihiro , Ishibashi Motoko , Miyoshi Youhei , Sugihara Yoshikazu 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Dipeptidyl Aspartyl Fluoromethylketones as Potent Caspase Inhibitors: SAR of the N‐Protecting Group.
Authors: Cai Sui Xiong , Guan Lufeng , Jia Shaojuan , Wang Yan , Yang Wu , Tseng Ben , Drewe John 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Histone Deacetylase Inhibitors: Cyclic Tetrapeptide with Trifluoromethyl and Pentafluoroethyl Ketones.
Authors: Jose Binoy , Oniki Yusuke , Kato Tamaki , Nishino Norikazu , Sumida Yuko , Yoshida Minoru 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Terpenic and Phenolic Glycosides from Leaves of Breynia officinalis Hemsl.
Authors: Morikawa Hiroyuki , Kasai Ryoji , Otsuka Hideaki , Hirata Eiji , Shinzato Takakazu , Aramoto Mitsunori , Takeda Yoshio 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Purine Modulation of Cytokine Release During Diuretic Therapy of Rheumatoid Arthritis
Authors: Forrest C. M. , Harman G. , McMillan R. B. , Rana C. , Shaw S. , Stone T. W. , Stoy N. , Darlington L. G. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Febuxostat (TMX‐67), a Novel, Non‐Purine, Selective Inhibitor of Xanthine Oxidase, Is Safe and Decreases Serum Urate in Healthy Volunteers
Authors: Becker M. A. , Kisicki J. , Khosravan R. , Wu J. , Mulford D. , Hunt B. , MacDonald P. , Joseph‐Ridge N. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Pharmacokinetics and Pharmacodynamics of Febuxostat (TMX‐67), a Non‐Purine Selective Inhibitor of Xanthine Oxidase/Xanthine Dehydrogenase (NPSIXO) in Patients with Gout and/or Hyperuricemia
Authors: Komoriya K. , Hoshide S. , Takeda K. , Kobayashi H. , Kubo J. , Tsuchimoto M. , Nakachi T. , Yamanaka H. , Kamatani N. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Detection of Prothrombin and Osteopontin in a Renal Stone Found in a Hyperuricemic Patient Using 2D‐PAGE and LC‐MS Analysis
Authors: Kaneko K. , Yamanobe T. , Nakagomi K. , Mawatari K. , Onoda M. , Fujimori S. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Are Allopurinol and Metabolites Found in HPRT Deficient Erythrocytes Responsible for Increased NAD Synthesis?
Authors: Micheli V. , Jacomelli G. , Sestini S. , Notarantonio L. , Cerboni B. , Peruzzi L. , Pompucci G. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
MPC1001, a New Antitumor Antibiotic Produced by Cladorrhinum sp.
Authors: Tsumagari Noriko , Nakai Ryuichiro , Onodera Hideyuki , Hasegawa Atsuhiro , Rahaya Endang S. , Ando Katsuhiko , Yamashita Yoshinori 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Hydrogen Bond and Protonation as Modifying Factors of the Quinone Reactivity
Authors: Aguilar‐Martinez M. , Macias‐Ruvalcaba N. A. , Bautista‐Martinez J. A. , Gomez M. , Gonzalez F. J. , Gonzalez I. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
P‐cadherin expression reduced in squamous cell carcinoma of the oral cavity
Authors: Muñoz‐Guerra Mario Fernando , Marazuela Eva G. , Fernández‐Contreras María Encarnacíon , Gamallo Carlos 
Published: January 2005

AbstractBACKGROUNDThe loss of cadherin expression has been shown to correlate to the invasion and metastasis of many types of carcinomas. The purpose of the current study was to evaluate whether the impaired expression of E‐cadherin (E‐cad) and P‐cadherin (P‐cad) correlated with the clinical evolution and prognosis of oral squamous cell carcinoma (OSCC).METHODSThe authors used immunohistochemical methods to analyze the expression pattern of E‐cad and P‐cad in healthy oral mucosa, in oral carcinoma in situ (CIS), and in surgical samples of 50 patients with the early stages (Stages I–II) of OSCC.RESULTSE‐cad showed weak expression in the basal layer of the healthy oral mucosa and reduced expression in patients with oral CIS. P‐cad expression was conserved on the basal and suprabasal layers of the healthy mucosa and, also, in the CIS. In the group of patients with OSCC, univariate analysis demonstrated that reduced expression of E‐cad or P‐cad correlated significantly with locoregional disease recurrence in the follow‐up (P= 0.03 andP= 0.01, respectively). However, only the reduction in the expression of P‐cad emerged as an independent prognostic marker in the multivariate analysis (P= 0.04, hazard ratio = 8.06).CONCLUSIONSThese findings suggested that a decrease in E‐cad and/or P‐cad expression may contribute to the invasive potential of early OSCC. According to the current data, P‐cad expression may be a potential independent prognostic factor in patients with OSCC. Cancer 2005. © 2005 American Cancer Society.
Percutaneous radiofrequency ablation for hepatocellular carcinoma
Authors: Tateishi Ryosuke , Shiina Shuichiro , Teratani Takuma , Obi Shuntaro , Sato Shinpei , Koike Yukihiro , Fujishima Tomonori , Yoshida Haruhiko , Kawabe Takao , Omata Masao 
Published: February 2005

AbstractBACKGROUNDRadiofrequency ablation (RFA) was introduced recently as a therapeutic modality for hepatocellular carcinoma (HCC), an alternative to percutaneous ethanol injection therapy (PEIT), which is coming into use worldwide. Previously reported treatment efficacy and complication rates have varied considerably.METHODSBetween February 1999 and February 2003, the authors performed 1000 treatments of RFA to 2140 HCC nodules in 664 patients with a cooled‐tip electrode at the University of Tokyo Hospital (Tokyo, Japan). Short‐term and long‐term complications were analyzed by treatment and session basis. Cumulative survival was also assessed in 319 patients who received RFA as primary treatment (naive patients) and 345 patients who received RFA for recurrent tumor after previous treatment including resection, PEIT, microwave coagulation therapy, and transarterial embolization (nonnaive patients).RESULTSA total of 40 major complications (4.0% per treatment, 1.9% per session) and 17 minor complications (1.7% per treatment, 0.82% per session) were observed during the observation period until March 31, 2004. There were no treatment‐related deaths. Surgical intervention was required in one case each of bile peritonitis and duodenal perforation. The cumulative survival rates at 1, 2, 3, 4, and 5 years were 94.7%, 86.1%, 77.7%, 67.4%, and 54.3% for naive patients, whereas the cumulative survival rates were 91.8%, 75.6%, 62.4%, 53.7%, and 38.2% for nonnaive patients, respectively.CONCLUSIONSThe authors confirmed the safety and efficacy of RFA for HCC in a large‐scale series and long‐term prognosis was satisfactory. Cancer 2005. © 2005 American Cancer Society.
A representation of acoustic waves in unbounded domains
Authors: Alpert Bradley K. , Chen Yu 
Published: February 2005

AbstractCompact, time‐harmonic, acoustic sources produce waves that decay too slowly to be square‐integrable on a line away from the sources. We introduce an inner product, arising directly from Green's second theorem, to form a Hilbert space of these waves and present examples of its computation.1 © 2005 Wiley Periodicals, Inc.
On the continuum limit of a discrete inverse spectral problem on optimal finite difference grids
Authors: Borcea Liliana , Druskin Vladimir , Knizhnerman Leonid 
Published: February 2005

AbstractWe consider finite difference approximations of solutions of inverse Sturm‐Liouville problems in bounded intervals. Using three‐point finite difference schemes, we discretize the equations on so‐called optimal grids constructed as follows: For a staggered grid with 2 k points, we ask that the finite difference operator (a k × k Jacobi matrix) and the Sturm‐Liouville differential operator share the k lowest eigenvalues and the values of the orthonormal eigenfunctions at one end of the interval. This requirement determines uniquely the entries in the Jacobi matrix, which are grid cell averages of the coefficients in the continuum problem. If these coefficients are known, we can find the grid, which we call optimal because it gives, by design, a finite difference operator with a prescribed spectral measure. We focus attention on the inverse problem, where neither the coefficients nor the grid are known.A key question in inversion is how to parametrize the coefficients, i.e., how to choose the grid. It is clear that, to be successful, this grid must be close to the optimal one, which is unknown. Fortunately, as we show here, the grid dependence on the unknown coefficients is weak, so the inversion can be done on a precomputed grid for an a priori guess of the unknown coefficients. This observation leads to a simple yet efficient inversion algorithm, which gives coefficients that converge pointwise to the true solution as the number k of data points tends to infinity. The cornerstone of our convergence proof is showing that optimal grids provide an implicit, natural regularization of the inverse problem, by giving reconstructions with uniformly bounded total variation. The analysis is based on a novel, explicit perturbation analysis of Lanczos recursions and on a discrete Gel'fand‐Levitan formulation. © 2005 Wiley Periodicals, Inc.
Interferon‐γ mediates antigen trafficking to MHC class II‐positive late endosomes of enterocytes
Authors: Büning Jürgen , Schmitz Martina , Repenning Birthe , Ludwig Diether , Schmidt Marcus Alexander , Strobel Stephan , Zimmer Klaus‐Peter 
Published: February 2005

AbstractMHC class II‐positive late endosomes of enterocytes are thought to be involved in antigen presentation to CD4+ T cells. In contrast to enterocytes of BALB/c mice, severe combined immunodeficiency (SCID) enterocytes lack MHC class II expression and fail to transport internalized ovalbumin (OVA) into late endosomes. IFN‐γ is known to induce MHC class II in enterocytes and antigen targeting to late endosomes in macrophages. In this study, we investigated the influence of IFN‐γ and MHC class II on the processes of antigen traffic in enterocytes. Subcellular targeting of OVA and MHC class II expression within enterocytes were examined in SCID, IFN‐γ‐treated SCID, BALB/c and C57BL/6 MHC class II knockout (KO) mice after a single feed with OVA. Sorting of OVA into late endosomes was found in enterocytes from BALB/c, C57BL/6 KO and IFN‐γ‐stimulated SCID mice, but not from untreated SCID mice. MHC class II expression was restricted to enterocytes of IFN‐γ‐treated SCID and BALB/c mice, present at basolateral membranes and within endosomal compartments. These enterocytes further revealed colocalization of class II antigens and OVA in endosomes. We suggest that antigen trafficking into late endosomes of enterocytes is mediated by IFN‐γ and occurs in the absence of MHC class II.
Notch1 co‐localizes with CD4 on activated T cells and Notch signaling is required for IL‐10 production
Authors: Benson Robert A. , Adamson Karen , Corsin‐Jimenez Marta , Marley Julia V. , Wahl Karen A. , Lamb Jonathan R. , Howie Sarah E. M. 
Published: February 2005

AbstractThe effector function of activated CD4+ T cells and secretion of cytokines are important in the establishment of productive immune responses and tolerance. We identified expression by CD4+ T cells of Notch receptors and ligands and enhanced Notch signaling upon activation. Notch1 expression was up regulated and co‐localized with CD4 upon T cell stimulation. Disruption of Notch signaling did not affect proliferation, but attenuated cytokine secretion following CD3 ligation in the absence of anti‐CD28 antibody. Notch signaling was absolutely necessary for transcription of IL‐10 by stimulated CD4+ T cells. CD4+ T cells transfected with constitutively active Notch1 failed to proliferate, but exhibited enhanced cytokine secretion upon stimulation. Our data indicates that Notch receptor signaling can influence both proliferative and cytokine responses of CD4+ T cells. In addition, the finding that Notch signaling is required for production of IL‐10 may allude to a role in immune regulation.
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β‐peptide
Authors: Townsend Kirk P. , Town Terrence , Mori Takashi , Lue Lih‐Fen , Shytle Doug , Sanberg Paul R. , Morgan David , Fernandez Francisco , Flavell Richard A. , Tan Jun 
Published: February 2005

AbstractAlthough deposition of amyloid β‐peptide (Aβ) as Aβ plaques involves activation of microglia‐mediated inflammatory responses, activated microglia ultimately fail to clear Aβ plaques in the brains of either Alzheimer's disease (AD) patients or AD mouse models. Mounting evidence suggests that chronic microglia‐mediated immune response during Aβ deposition etiologically contributes to AD pathogenesis by promoting Aβ plaque formation. However, the mechanisms that govern microglia response in the context of cerebral Aβ/β‐amyloid pathology are not well understood. We show that ligation of CD40 by CD40L modulates Aβ‐induced innate immune responses in microglia, including decreased microglia phagocytosis of exogenous Aβ1–42 and increased production of pro‐inflammatory cytokines. CD40 ligation in the presence of Aβ1–42 leads to adaptive activation of microglia, as evidenced by increased co‐localization of MHC class II with Aβ. To assess their antigen‐presenting cell (APC) function, cultured microglia were pulsed with Aβ1–42 in the presence of CD40L and co‐cultured with CD4+ T cells. Under these conditions, microglia stimulate T cell‐derived IFN‐γ and IL‐2 production, suggesting that CD40 signaling promotes the APC phenotype. These data provide a mechanistic explanation for our previous work showing decreased microgliosis associated with diminished cerebral Aβ/β‐amyloid pathology when blocking CD40 signaling in transgenic Alzheimer's mice.
Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum
Authors: Dooley Helen , Flajnik Martin F. 
Published: February 2005

AbstractThe cartilaginous fish are the oldest phylogenetic group in which all of the molecular components of the adaptive immune system have been found. Although early studies clearly showed that sharks could produce an IgM‐based response following immunization, evidence for memory, affinity maturation and roles for the other isotypes (notably IgNAR) in this group remained inconclusive. The data presented here illustrate that the nurse shark (Ginglymostoma cirratum) is able to produce not only an IgM response, but we also show for the first time a highly antigen‐specific IgNAR response. Additionally, under appropriate conditions, a memory response for both isotypes can be elicited. Analysis of the response shows differential expression of pentameric and monomeric IgM. Pentameric IgM provides the ‘first line of defense’ through high‐avidity, low‐affinity interaction with antigen. In contrast, monomeric IgM and IgNAR seem responsible for the specific, antigen‐driven response. We propose the presence of distinct lineages of B cells in sharks. As there is no conventional isotype switching, each lineage seems pre‐determined to express a single isotype (IgM versus IgNAR). However, our data suggest that there may also be specific lineages for the different forms (pentameric versus monomeric) of the IgM isotype.
Analysis of transforming growth factor‐β1‐induced Ig germ‐line γ2b transcription and its implication for IgA isotype switching
Authors: Park Seok‐Rae , Seo Goo‐Young , Choi Ae‐Jin , Stavnezer Janet , Kim Pyeung‐Hyeun 
Published: February 2005

AbstractTransforming growth factor (TGF)‐β1 directs class switch recombination (CSR) to IgG2b as well as to IgA. Smad3/4, Runx3 and p300 mediate TGF‐β1‐induced germ‐line (GL) α transcription leading to IgA expression. However, the molecular mechanisms by which TGF‐β1 induces IgG2b CSR are unknown. We used luciferase reporter plasmids to investigate how TGF‐β1 regulates the activity of the promoter for GL transcripts of IgG2b constant gene (GLγ2b promoter). Similarly to the GLα promoter, overexpression of Smad3/4 and Runx3 enhances TGF‐β1‐induced GLγ2b promoter activity. Mutation analysis of the promoter identified likely Smad‐ and Runx3‐binding sites. Also similar to the GLα promoter, overexpression of p300 enhances Smad3/4‐mediated promoter activity, whereas E1A represses promoter activity. Since these regulation mechanisms underlying both GLα and GLγ2b transcription are similar, we explored the possibility that TGF‐β1 induces IgA CSR via transitional IgG2b CSR. TGF‐β1 enhances the expression of both Iα‐Cμ and Iα‐Cγ2b circle transcripts, indicative of direct (Sμ→Sα) and sequential CSR (Sμ→Sγ2b→Sα).
An extended family of Fc receptor relatives
Authors: Davis Randall S. , Ehrhardt Goetz R. A. , Leu Chuen‐Miin , Hirano Masayuki , Cooper Max D. 
Published: February 2005

AbstractA surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1–6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes. FcRH immunoregulatory potential is implicated by the presence of consensus tyrosine‐based activation or inhibition motifs in their cytoplasmic tails. All but one of these new receptors, FcRH6, are expressed on B cells at different stages in differentiation. Their ligands, function, and prospective roles as diagnostic B cell markers and therapeutic targets are topics of intense interest.
Seismic response of linear and non‐linear asymmetric systems with non‐linear fluid viscous dampers
Authors: Goel Rakesh K. 
Published: January 2005

AbstractThis investigation is concerned with the seismic response of one‐story, one‐way asymmetric linear and non‐linear systems with non‐linear fluid viscous dampers. The seismic responses are computed for a suite of 20 ground motions developed for the SAC studies and the median values examined. Reviewed first is the behaviour of single‐degree‐of‐freedom systems to harmonic and earthquake loading. The presented results for harmonic loading are used to explain a few peculiar trends—such as reduction in deformation and increase in damper force of short‐period systems with increasing damper non‐linearity—for earthquake loading. Subsequently, the seismic responses of linear and non‐linear asymmetric‐plan systems with non‐linear dampers are compared with those having equivalent linear dampers. The presented results are used to investigate the effects of damper non‐linearity and its influence on the effects of plan asymmetry. Finally, the design implications of the presented results are discussed. Copyright © 2005 John Wiley & Sons, Ltd.