bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of tralokinumab for atopic dermatitis: a meta-analysis of randomized controlled studies
Authors: He Chengwei 
Published: January 2024

Abstract
Introduction:
The efficacy of tralokinumab for atopic dermatitis remains controversial. We conduct a systematic review and meta-analysis to explore the efficacy of tralokinumab in patients with atopic dermatitis.
Methods
We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2023 for randomized controlled trials (RCTs) assessing the efficacy of tralokinumab for atopic dermatitis. This meta-analysis is performed using the random-effect model.
Results
Three RCTs are included in the meta-analysis. In patients with atopic dermatitis, tralokinumab is associated with improved IGA score of 0/1 (RR = 1.77; 95% CI = 1.39 to 2.27; P < 0.00001) and EASI 50 (RR = 1.73; 95% CI = 1.31 to 2.29; P = 0.0001), reduced SCORAD score (SMD=-9.28; 95% CI=-11.58 to -6.99; P < 0.00001) and increased SCORAD 50 (RR = 2.28; 95% CI = 1.78 to 2.91; P < 0.00001), but reveals no obvious impact on adverse events (RR = 0.97; 95% CI = 0.91 to 1.03; P = 0.30) or serious adverse events (RR = 0.88; 95% CI = 0.49 to 1.60; P = 0.68).
Conclusions
Tralokinumab may be effective and safe to treat atopic dermatitis.
Engineering a Copper (II) Functionalized Silk Fibroin Film for Cellular Behavior Modulation
Authors: Wang Hong-Hui , Li Juan , Xiong Jing , Liu Bowen , He Fang , Li Zhu , Cai Na , Xing Hang , Shi Liyang 
Published: January 2024

Abstract
Engineering silk fibroin-based biomaterials with tunable functional properties is pivotal for the next generation of tissue engineering and regenerative medicine. We introduce a novel surface engineering technique that harnesses the unique chemistry of silk fibroin to fabricate films with controlled release of copper (II) ions (Cu2+), known to enhance wound healing processes. By employing a facile film-forming solution and subsequent modification with polydopamine (PDA), we developed silk fibroin (SF) films coated withCuNPs, termed SF-PDA-CuNPs (SPC). This innovative methodology is not only straightforward and reproducible but also effective in functionalizing silk fibroin. Our engineered SPC films demonstrate a slow and sustained release of bioactive Cu2+ for a marked acceleration in wound closure of living mammalian cells. These findings underscore the potential of Cu2+-loaded SF films as a novel strategy for enhancing wound repair, opening new avenues for the application of silk fibroin in advanced wound care solutions.
Design and Development of a Second-class Lever for Maize Shelling Operation
Authors: Nwogu C. N. , Nwankwojike B. N. , Onwuka O. S. , Chima M. O. , Orji F. N. , Eze C. E. , Udo V. U. 
Published: January 2024

Abstract
In this study, a lever was designed for manual shelling of maize. The lever is made up of a 30 mm diameter rod with a 10 mm diameter hole drilled at one end and a 20 mm diameter rod welded vertically to the rod, 400 mm from the other end. The maize ear is placed inside a 70 mm diameter tube before shelling and when the lever is pushed the maize ear is forced through the shelling tube, and in the process the seeds fall off the cob. Explicit Dynamic Analysis of the lever done in Ansys showed that the lever will effectively shell maize ears without damage to both seed and cob. Results of the Analysis gave 0.26485 m and of -9.7419e− 8 m as maximum and minimum values of directional deformation, 76386 Pa and 0 Pa respectively as maximum and minimum values of equivalent stress, 9,4005e− 6 m/m and 0 m/m as maximum and minimum values of equivalent strain, 29.507 m/s2 and 7e− 2 m/s2 as maximum and minimum values of total acceleration, and 21085 Pa and − 23604 Pa as maximum and minimum values of shear strain respectively. This study therefore develops and new and cost-effective means of shelling maize ears which requires neither electricity nor any sort of fuel to operate.
Dynamic Analysis of a G+13 Storey Rcc Building Using Shear Wall in Three Different Location on Various Seismic Zone
Authors: K Md. Kawsarul Islam Kabbo Md. Kawsarul Islam 
Published: January 2024

Abstract
Currently Seismic impacts getting very serious concern when designing multi-storied reinforced concrete structures. Seismic tremors have occurred in numerous parts of the globe. High-rise structures should have proper stiffness to resist lateral loads caused by Earthquakes and Winds. Consequently, Engineers are extremely concerned about finding suitable solution that will allow structures to survive without major damage. Shear walls are structural members which are designed to carry earthquake loads and opposes lateral loads significantly. They are good choice to increase stiffness of high-rise structures. This paper aims to use shear walls in various location of a G+13 multi-storied residential building and to determine the best shear wall placement in high slender building by analyzing storey displacement, storey drift, base shear and fundamental time period in various seismic zones according to IS 1893:2016. Three models are prepared and compared under different seismic zones. Shear walls at core of building, shear walls at four corners of building and the combination of both. Our study's goal is to test a structure's ability to bear lateral load applied to it according to Code and also when it exceeds the limit of allowable deformation. The prepared model for this experimentation is considered to be located on medium soil and wind velocity is high like 148mph. The experiment concluded that, building with shear wall combination of both core and corner will show better result to resist lateral forces though the combination isn’t enough to help withstanding the high slender structure against very powerful earthquake attack like Zone-v.
Integrating Bio Principles in Assembly Task Design to Enhance Symbiotic Human-Robot Collaboration
Authors: Barravecchia Federico , Bartolomei Mirco , Mastrogiacomo Luca , Franceschini Fiorenzo 
Published: January 2024

Abstract
The advancement of Human-Robot Collaboration (HRC) in industrial environments has underscored the importance of establishing harmonious and symbiotic relationships between humans and robots. This study, in line with the principles of Industry 5.0, proposes an approach to support the integration of human capabilities with advanced robotics, enhancing collaborative productivity and fostering a paradigm shift towards a more interactive and beneficial human-robot symbiosis. Prior research has established the basic principles of Symbiotic Human-Robot Collaboration (SHRC), but has often neglected the critical problem of how to conduct collaborative tasks to exploit the potential of these symbiotic interactions. This paper presents a novel methodology to support the design of protocols for collaborative tasks, with the aim of promoting positive symbiotic interactions between humans and collaborative robots. The focus is on developing tasks that naturally integrate positive symbiotic interactions, which involves determining task performers and optimizing the mutual benefits derived from task execution. A case study is presented to illustrate the practical application of this methodology in a real-world context.
Immuno-persistence after the 4th and 5th dose of inactivated polio vaccines in school-aged children
Authors: Leung Kathy , Pang Chrissy Wing Kwan , Lo Tiffany Hoi Ki , Vargas-Zambrano Juan , Petit Céline , Lam Tommy Tsan-Yuk , Lau Eric , Wu Joseph 
Published: January 2024

Abstract
Despite decades of research, questions remain about the persistence of neutralising antibodies (nAb) and serological correlates of polio vaccine efficacy. In a cross-sectional study among 299 children in Hong Kong, we estimated that the mean nAb titres against polioviruses type 1, 2 and 3 (PV1, PV2 and PV3) one month after receiving the 4th dose of inactivated polio vaccine (IPV) at 19 months of age were 2,068 (95% credible interval: 1,517 – 2,864), 4,705 (3,439 – 6,436) and 2,758 (1,894 – 4,086), but declined substantially in 4 years to 268 (222 – 325), 751 (630 – 900), and 411 (323 – 521), respectively. Administration of the 5th dose of IPV restored nAb titres among children aged 6-7 years, and the decline in nAb titres was slightly slower with the estimated mean titres of 355 (272 – 462), 538 (427 – 681), and 548 (378 – 786) against PV1, PV2, and PV3 at 4 years post the 5th dose. We estimated that the proportion of children who were seroprotected against PV1, PV2 and PV3 would drop below 90% at: (i) 8.2, 10.8, 8.7 years after the 4th dose; and (ii) 11.6, 11.2, 11.0 years after the 5th dose, highlighting the importance of maintaining populational immune persistence at high nAb levels.
The Effects of Open/Closed Kinetic Chain Exercises in Water on the Electrical Activity of Selected Lumbar Muscles, Lumbopelvic Control, Ground Reaction Force, and Psychological Factors in Men with Chronic Non-Specific Low Back Pain: A Study Protocol for a Randomized Crossover Clinical Trial
Authors: Ali Yalfani , Ashoury Hossien , Arjipour Mahdi 
Published: January 2024

Abstract
Background
Chronic non-specific low back pain (CNSLBP) has been documented among the top causes of absenteeism at work, coupled with the use of health insurance and healthcare services. Considering little research on the consequences of open/closed kinetic chain (O/CKC) exercises in water on the CNSLBP improvement, the present study is to investigate the effects of such interventions on the electrical activity of selected lumbar muscles, pain, lumbopelvic control (LPC), ground reaction force (GRF) for balance analysis, and psychological factors in men with CNSLBP.
Methods
In this randomized crossover clinical trial, 60 adult male participants with CNLBP, at the age range of 40–60, will be assigned to one of the following three groups through the block randomization method, viz., open kinetic chain (OKC) exercises, closed kinetic chain (CKC) exercises, and controls. The primary outcomes of the electrical activity of the multifidus (MF), transversus abdominis (TrA), gluteus medius (GM), and quadratus lumborum (QL) muscles will be then measured by an electromyography (EMG) device. As well, the pressure biofeedback (BFB) device and the visual analogue scale (VAS) will be utilized to assess LPC and pain intensity, respectively. The secondary outcomes of the GRF along with foot pressure and kinesiophobia will be subsequently measured by the Tampa Scale of Kinesiophobia (TSK).
Conclusion
The study results develop a comprehensive treatment protocol with much emphasis on maintaining its effectiveness and practicality in daily living activities, such as walking, going up and down the stairs, sitting on and getting up from chairs and couches, and sleeping pain-free, and provides a therapeutic solution for physiotherapists and sports therapists.
Trial registration
This trial was approved by the ethics committee for human research of BuAliSina University (reference number: IR.BASU.REC.1402.011) and IRCT CODE (20190129042534N1).
Agrobacterium–mediated genetic engineering system for the C4 apomictic grass model species Cenchrus ciliaris L.
Authors: . Shashi , Dwivedi Anuj , Abhishek Mahalakshmi 
Published: January 2024

Abstract
Cenchrus ciliaris L. (buffel grass) is a popular tropical range grass known for its perenniality and high palatability. Owing to its apomictic mode of reproduction, breeding this polymorphic grass is restricted to in vitro approaches of genetic manipulation. Apomixis facilitates genetic improvement by fixing heterosis as well as the changes made to the genome through transgenesis. Towards its genetic improvement, a robust protocol of plant transformation is desirable. Hence, first attempt to develop a rapid and efficient Agrobacterium– mediated transformation system for Cenchrus ciliaris genotype IG-3108 has been made. In this study, direct multiple shoot induction protocol using shoot apex explants was found to be suitable for transformation. Several factors such as inoculum of bacteria, co–culture time, co–cultivation duration, concentration of acetosyringone and effect of vacuum infiltration were optimized for achieving high transformation frequency using shoot apex explants. The shoot apex explants were co-cultured with EHA 105 harbouring the binary vectors pCAMBIA 1301 and 1305.1 containing the hptII gene as a selectable marker and GUSA as a reporter gene. The highest transformation frequency with pCAMBIA 1301 vector was 1.42% while with pCAMBIA 1305.1 vector, it was 1.37% when the explants were co-cultured for 30 min with cells of Agrobacterium at OD600 = 1.0 under vacuum (0.5 X 105 Pa) followed by co-cultivation for 3 days on MS with 3 mg/L TDZ and 400 µM acetosyringone. The status of transgene and its integration in the genome of regenerated putative transformed plants of Cenchrus were confirmed by PCR and Southern blot analysis.
Inflammatory Biomarker Correlations and Prognosis in High-risk Gastrointestinal Stromal Tumor Patients: A Multicenter Retrospective Analysis
Authors: Wang Tao , Qi Lihua , Zhao Yang , Ma Xiaolan , Li Tao 
Published: January 2024

Abstract
Background
The intricate prognosis of gastrointestinal stromal tumors (GISTs) has garnered significant attention, yet a gap persists in understanding the influence of inflammatory markers on the prognosis of high-risk GIST patients. This study investigated the relationship between various factors and the prognosis of high-risk GIST patients, with a specific focus on first recurrence-free survival (RFS) and overall survival (OS) as crucial prognostic indicators.
Methods
A comprehensive collection of clinical data was conducted on 145 high-risk GIST patients meeting specific inclusion and exclusion criteria at 17 medical centers in Ningxia, China, covering the period from January 2013 to December 2019. Single-factor analysis and survival curves were used to analyze the variables, while the Cox regression model evaluated independent prognostic factors.
Results
Within the cohort, a balanced male-to-female ratio of 1:1.1 was observed. Single-factor analysis revealed compelling associations between RFS and age, preoperative neutrophil-to-lymphocyte ratio (NLR), preoperative platelet-to-lymphocyte ratio (PLR), preoperative systemic immune-inflammatory index (SII), preoperative prognostic nutritional index (PNI), mitotic index, and imatinib (IM) with RFS in high-risk GIST patients. These variables also exhibited statistically significant associations with OS (all with p values < 0.05). Cox regression analysis revealed that age, preoperative NLR, mitotic index, IM, and adjuvant therapy independently impacted RFS. Additionally, the preoperative NLR and mitotic index emerged as independent factors influencing OS, all of which demonstrated statistical significance (p values < 0.05). Age exhibited a negative correlation with RFS, and early regular IM treatment following surgery significantly decreased the recurrence risk. An elevated NLR and higher mitotic indices were strongly linked to poorer RFS and OS.
Conclusion
The data revealed a significant correlation between age, preoperative NLR, and mitotic index and an unfavorable prognosis in high-risk GIST patients. Notably, the NLR was identified as a potential additional prognostic factor, enhancing the accuracy of predicting treatment efficacy and patient outcomes in high-risk patients with GISTs. Therefore, we advocate for the serious consideration of the NLR as a valuable addition to standard clinical practice for managing high-risk GIST patients.
Significant Thinning of Peripapillary Retinal Nerve Fiber Layer in Leber’s Hereditary Optic Neuropathy: An Optical Coherence Tomography Angiography Analysis Running title: Running title: RNFL in LHON by OCTA
Authors: Liu Zhengfeng , Pan Xuemei , Li Zhongen , Wang Dan , Zou Yingying , Sha Fang , Xie Xiaofeng , Bi Hongsheng 
Published: January 2024

Abstract
Purpose
To analyse the peripapillary retinal nerve fiber layer (RNFL) by optical coherence tomography angiography (OCTA) in Leber’s hereditary optic neuropathy (LHON) in m.11778G > A mutation in the MT-ND4 gene.
Method
This work is a retrospective study and included 24 eyes from 12 patients with LHON. Fifteen healthy people with 30 eyes matched to the age and gender of the patient group were recruited as a normal control group. All of the LHON patients with m.11778G > A mutation were diagnosed by genetic testing. Peripapillary RNFL included 360-degree average and eight sectors (superotemporal, superonasal, nasoupper, nasolower, inferonasal, inferotemporal, temporolower, temporoupper) were measured by OCTA.
Results
Compared with control group, peripapillary RNFL in LHON group were significant thinner in average thickness (p < 0.01) and eight sectors (all p < 0.01).
Conclusions
OCTA results confirm that peripapillary RNFL is significant thinner in LHON patients. OCTA can evaluate eight sectors RNFL damage on LHON patients.
M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis
Authors: Zhu Xiaolan , Li Wenxin , Lu Minjun , Shang Junyu , Zhou Jiamin , Lin Li , Liu Yueqin , Xing Jie , Zhang Mengxue , Zhao Shijie , Lu Jingjing , Shi Xuyan 
Published: January 2024

Abstract
Background: Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical and psychological health of patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on ovarian function with unclear mechanisms.
Methods: A comprehensive analysis of the Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs and miRNAs. The relationship between HucMSC-derived exosomal circBRCA1/miR-642a-5p/FOXO1 axis and POI was examined by RT-qPCR, Western blotting, reactive oxygen species (ROS) staining, senescence-associated β-gal (SA-β-gal) staining, JC-1 staining, TEM, oxygen consumption rate (OCR) measurements and ATP assay in vivo and in vitro. RT-qPCR detected the expression of circBRCA1 in GCs and serum of patients with normal ovarian reserve function (n=50) and patients with POI (n=50); then, the correlation of circBRCA1 with ovarian reserve function indexes was analyzed.
Results: Herein, we found that circBRCA1 was decreased in the serum and ovarian granulosa cells (GCs) of patients with POI and was associated with decreased ovarian reserve. H-Exs improved the disorder of the estrous cycles and reproductive hormone levels, reduced the number of atretic follicles, and alleviated the apoptosis and senescence of GCs in rats with POI. Moreover, H-Exs mitigated mitochondrial damage and reversed the reduced circBRCA1 expression induced by oxidative stress in GCs. Mechanistically, FTO served as an eraser to increase the stability and expression of circBRCA1 by mediating the m6A demethylation of circBRCA1, and exosomal circBRCA1 sponged miR-642a-5p to block its interaction with FOXO1. CircBRCA1 insufficiency aggravated mitochondrial dysfunction, mimicking FTO or FOXO1 depletion effects, which was counteracted by miR-642a-5p inhibition.
Conclusion: H-Exs secreted circBRCA1 regulated by m6A modification, directly sponged miR-642a-5p to upregulate FOXO1, resisted oxidative stress injuries in GCs and protected ovarian function in rats with POI. Exosomal circBRCA1 supplementation may be a general prospect for the prevention and treatment of POI.
Molecular dynamics simulation and performance verification of γ-polyglutamic acid/cold water–soluble starch film formation and permeability
Authors: Yu Zuolong , Chen Yao , Chen Yongfei , Wei Yunxiao , Fu Changchun , Liu Dan , Niranjan Keshavan , Han Chao 
Published: January 2024

Abstract
Six types of γ-polyglutamic acid (γ-PGA)/cold water–soluble starch (St) composite-film models were constructed using molecular dynamics simulation, and their properties were investigated and compared with the corresponding experimental values. The compatibility between the composite film componentswas analyzed using the radial distribution function and mean square displacement (MSD). The hydrogen bond number and bond energy were used to track the film-formation process. The mechanical property data of the films were extracted, and MSD was used to analyze the permeability of the film to carbon dioxide, oxygen, water vapor, and carbon-16 saturated fatty acids. Finally, the simulated values of mechanical properties and permeability were compared with the experimental values. The results demonstrated that γ-PGA is well compatible with St. The intramolecular and intermolecular hydrogen bonds of γ-PGA and St did not change considerably during the film-formation process. The simulated values of the mechanical properties exhibited a similar trend as the experimental values; however, in terms of permeability, a difference was observed between the initial values of the simulated design and actual material parameters, as well as the complexity of the experiment.
Successful open surgical treatment for persistent type Ⅱ endoleak following thoracic endovascular aortic repair: A case report
Authors: Lee June , Kim Do Yeon , Lim Hyun Ah , Hong Seok Beom , Kim Yong Han , Kim Hwan Wook 
Published: January 2024

Abstract
Background: The occurrence of type II endoleaks after repair of endovascular aortic aneurysm has gradually gained increasing attention. We present a case of a patient with an expanding aneurysm after thoracic endovascular aortic repair (TEVAR) for a type II endoleak, in which successful direct ligation of the intercostal artery was performed using a sacotomy with no cardiopulmonary bypass (CPB) or graft replacement.
Case presentation: A 62-year-old male patient, previously treated with TEVAR for a descending thoracic aortic aneurysm, presented with ongoing chest discomfort. Based on the diagnosis of a growing aneurysm and type II endoleak, a longitudinal opening of the thoracic aortic aneurysm sac was performed following left thoracotomy. The patient was scheduled for CPB and aortic cross-clamping, as a precautions against the possibility of a type I endoleak. Visual confirmation identified the T5 level intercostal artery as the source of the endoleak, and after confirming the absence of a type I endoleak, multiple ligations were applied to the intercostal artery. Follow-up computed tomography confirmed the absence of endoleaks or sac growth.
Conclusion: After performing TEVAR for a thoracic aortic aneurysm, open suture ligation was used to treat type II endoleaks without having to resort to CPB, resulting in successful outcomes.
Infertility Effects of methanol extract of Abrus Precatorius seeds on Reproductive, Hepatic and Renal function in female albino rats
Authors: Poli Venkataramanaiah , Motireddy Srinivasulu Reddy 
Published: January 2024

Abstract
Background
Abrus precatorious is a member of the leguminous family with characterstic red and black seeds. The leaves, roots and seeds of Abrus precatorious are used medicinally. The aim of this study was to investigate the antifertility activity of crude extract of A. precatorius seeds (extracted in to 70% Methanol) in female albino rats.
Methods
The female rats were grouped into two with six rats of each. Control group received normal saline. Female albino rats were administered APS (45 and 50 mg/kg) by oral gavage daily for a period of 30 days and body weights were recorded.
Results
All the results showed that the reproductive parameters were such as Body weight, Organ Weight, Estrous cycle, Hormonal Concentrations, Antioxidant Enzymes (Tissue), Enzymatic Activities (Tissue), Serum Biochemical indices (Liver and Kidney panel) and Hematological parameters analysed were found to show a significant difference (p < 0:05) between the means of the treated groups.
Conclusion
The study provides evidence for the potential ameliorative effects of A. precatorius seeds may possess anti-fertility effect in female rats.