bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and Components of Thyroid Status Evaluation in Commercially Insured Adults in the United States, 2006-2020
Authors: Morris Earl J , Vouri Scott M , Maraka Spyridoula , Singh Ospina Naykky 
Published: October 2023

Abstract

Context
Thyroid-stimulating hormone (TSH) is one of the most ordered laboratory tests.

Objective
Determine trends of TSH testing rates and components of thyroid function testing.

Methods
This was a retrospective analysis of adults 18-64 years old without evidence of thyroid disease with at least 365 days of continuous enrollment between 2006 and 2020 in the IBM MarketScan Claims Database. The main outcome measures were trends of TSH tests/1000 eligible patient-months stratified by age, sex, and region and composition of thyroid function testing.

Results
Among 67 353 280 patients meeting eligibility criteria, we identified 25 606 518 TSH tests and 15 138 211 patients with ≥1 TSH test. Patients contributing an episode of TSH testing were most commonly 45-54 years old (29.8%) and female (63.6%). TSH testing rates remained consistent throughout the study period with 11.4 and 11.7 TSH tests/1000 person-months in the first and last study months, respectively (mean 12.2 TSH tests/1000 person-months). TSH testing rates dropped sharply in the spring of 2020 (4.2 TSH tests/1000 person-months). Females showed a nearly 2-fold higher rate of TSH testing than males (16.1 TSH tests/1000 person-months vs 8.6 TSH tests/1000 person-months). TSH testing rates increased with age (8.2 TSH tests/1000 person-months among individuals 18-34 years old vs 15.4 TSH tests/1000 person-months among individuals 55-64 years old). No difference in TSH testing rates was noted between regions. Thyroid function testing episodes included only TSH in most cases (70.8%).

Conclusion
TSH testing rates among commercially insured individuals without known thyroid disease appears stable over time, with higher frequency in females and with increasing age.
Treatment of Intrathecal Drug Pump Flipping Using Fascial Flaps: A Technical Description and Case Series
Authors: Taghlabi Khaled M. , Bhenderu Lokeshwar S. , Guerrero Jaime R. , Hagopian Alexa De la Fuente , Farhat Souha , Rajendran Sibi , Cruz-Garza Jesus G. , Dinh Tue , Faraji Amir H. 
Published: October 2023

BACKGROUND AND OBJECTIVES:
Intrathecal drug therapy is a common treatment for dystonia, pain, and spasticity using implanted pump and catheter systems. Standardized management of intrathecal drug pump (ITDP) migration and flipping has not been well established in the literature. This study reports the use of soft tissue to address less common pump complications such as pump flipping, migration, and difficulty in medication refill.

METHODS:
A retrospective chart review of intrathecal pump cases performed by two surgeons between February 2020 and August 2022 was conducted. Patients with complications such as pump flipping, migration, or challenges in medication refill treated with soft tissue flaps were included. Patient demographics, comorbidities, and perioperative data were collected.

RESULTS:
A total of five patients with ITDP complicated by pump flipping, migration, malposition, or difficulty in medication refill that were treated using fascial flaps were included in the study. Three technical considerations when revising ITDP complications are secure pump anchoring, reliable wound closure, and ease of pump medication refill. Cases 1 and 2 demonstrate the technique of secure pump anchoring with a rectus fascial flap. Cases 3 and 4 show a technique to achieve reliable vascularized wound closure, and case 5 describes a technique to solve an uncommon problem of a thick subcutaneous abdominal tissue preventing the refill of the ITDP medication.

CONCLUSION:
Soft tissue flaps may serve as a treatment option for patients with uncommon ITDP complications. De-epithelialized dermal fasciocutaneous or fascial flaps may be developed to anchor the pump more securely. Cross-discipline collaboration may further delineate the technique, benefits, and outcomes of this approach.
Oral Contraception Use and Musculotendinous Injury in Young Female Patients: A Database Study
Authors: RODRIGUEZ LUIS A. , LIU YIDA , SOEDIRDJO SUBARYANI D. H. , THAKUR BHASKAR , DHAHER YASIN Y. 
Published: October 2023

ABSTRACT

Purpose
The purpose of this study is to characterize the effect of sex and the influence of oral contraception usage on musculotendinous injury (MTI). Current literature suggests a disparity in the incidence of MTI between males and females. This may be attributed to inherent biological differences between the sexes, such as in the sex hormonal milieu. There is a lack of information associating sex hormone milieu and MTI.

Methods
We searched the PearlDiver database (a for-fee healthcare database) for males, females taking oral contraceptives (OC), and eumenorrheic females not taking any form of hormonal contraceptives (non-OC) 18–39 yr old. The three populations were matched by age and body mass index. We queried the database for lower-extremity skeletal MTI diagnoses in these groups.

Results
Each group contained 42,267 patients with orthopedic injuries. There were a total of 1476 (3.49%) skeletal MTI in the male group, 1078 (2.55%) in non-OC females, and 231 (0.55%) in OC females. Both the non-OC and the OC groups had a significantly smaller proportion of MTI than males (P < 0.0001), and therefore these groups were less likely (adjusted odds ratios, 0.72 and 0.15, respectively) to experience MTI when controlled for potential covariates.

Conclusions
In this study, we show that females are less likely to develop MTI to total injuries, when compared with males, with OC using females being least likely followed by non-OC females. These results are consistent with other epidemiological studies; however, overall results in the literature are variable. This study adds to the emerging body of literature on sex hormone–influenced musculoskeletal injury but, more specifically, MTI, which have not been rigorously investigated.
Angiographic characteristics of culprit lesions in infarct related artery and correlation of TIMI score with SYNTAX score to predict extent and severity of coronary artery disease in patients undergoing primary percutaneous coronary interventions
Authors: Rizwanullah  , Sial Jawaid Akbar , Ali Nasir , Shehzad Muhammad 
Published: October 2023

Objective: The current study was designed to explore the relationship of TIMI and SYNTAX risk score to predict the CAD extent and severity in STEMI patients.
Methods: For this cross-sectional study, 304 STEMI patients undergoing PPCI were enrolled at Department of Interventional Cardiology NICVD Karachi from September 2021 to January 2022. and the TIMI risk score was determined at enrolment. Based on these scorings, the patients were grouped as low, intermediate, and high risk, i.e., a score of ≤ 3, 4 to 7, and ≥ 8, respectively. The SYNTAX scores were utilized to assess the extent of CAD.
Results: Statistically significant difference was found in symptoms to balloon time (p=0.001), history of diabetes (p=0.006), angina (p=0.011), obesity (p=0.048), STEMI type (p=0.003), Killip classes (p=0.000), Infarct-Related Artery (p=0.006), number of diseased vessels (p<0.01), LMS > 50% (p=0.000), PCI type (p<0.01), collateral circulation (p<0.01), In-hospital mortality (p<0.01), LV support (p<0.01), and post-procedural TIMI flow (p=0.013), among the three TIMI risk groups. Significant correlation was found among TIMI risk score and SYNTAX score.
Conclusion: It is observed that the TIMI risk scores are highly correlated with the SYNTAX Score in predicting the CAD severity in STEMI patients.
doi: https://doi.org/10.12669/pjms.40.1.7750
How to cite this: Rizwanullah, Sial JA, Ali N, Shehzad M. Angiographic characteristics of culprit lesions in infarct related artery and correlation of TIMI score with SYNTAX score to predict extent and severity of coronary artery disease in patients undergoing primary percutaneous coronary interventions. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7750
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Regional GPS orbit determination using code-based pseudorange measurement with residual correction model
Authors: Lee Hong Sheng , Wan Aris Wan Anom , Musa Tajul Ariffin , Sha’ameri Ahmad Zuri , Wei Han Ooi , Lee Dong-Ha , Mustafar Mohammad Asrul 
Published: October 2023

Abstract
The study introduces the concept of regional GPS orbit determination, whereby GPS satellite positions are determined using GPS measurements from locally or regional distributed stations. The importance and characteristics of regional GPS orbit are briefly discussed. The technique used to determine the regional GPS satellite position is coined Inverse Single Point Positioning (ISPP). Code-based pseudorange is used and improved using residual correction model. Two designs of station distribution are selected in this study, which only cover stations in Malaysia and stations situated 8000 km from a reference point in Malaysia. The root-mean-squared-error (RMSE) of ISPP when compared against final ephemeris were 660.65 m and 27.61 m, while the 3D RMSE of positioning were 1.612 m and 1.324 m for the first and second designs, respectively, lower than the accuracy of broadcast ephemeris. Three parameters are identified as factors affecting accuracy of ISPP, namely geometry of station distribution, nature of measurement used, and technique of orbit determination. Further research will be required to fully realize a functional regional GPS orbit.
Human Mobility and the Spread of Innovations – Case Studies from Neolithic Central and Southeast Europe
Authors: Scharl Silviane 
Published: October 2023

Abstract
The spread of innovations is an important driver for transformation processes in human societies. It is carried by two crucial conditions – the flow of information and the adoption/appropriation of the innovation. While the latter is a social and cultural process, the first is among others carried by mobility. Mobility in this context can take on different forms and range from migration events up to small-scale everyday mobility between neighbours. In this article, the transmission of ideas and technology without major migration events will be treated. This is based on two case studies – the spread of agriculture from Central Europe to South Scandinavia and the spread of copper metallurgy from Southeast to Central Europe. For both, the spatio-temporal spread of the innovation will be described and factors influencing the information flow and the process of adoption will be taken into account. This will help to develop a more detailed understanding concerning the transmission of ideas and technology without major migration events and allows us to follow the question of what roles did mobility and other factors play in it.
Does the Mott problem extend to Geiger counters?
Authors: Schonfeld Jonathan F. 
Published: October 2023

Abstract
The Mott problem is a simpler version of the quantum measurement problem that asks: Is there a microscopic physical mechanism – based (explicitly or implicitly) only on Schroedinger’s equation – that explains why a single alpha particle emitted in a single spherically symmetric s-wave nuclear decay produces a manifestly nonspherically symmetric single track in a cloud chamber? I attempt here to generalize earlier work that formulated such a mechanism. The key ingredient there was identification of sites at which the cross section for ionization by a passing charged particle is near singular at ionization threshold. This near singularity arose from a Penning-like process involving molecular polarization in subcritical vapor clusters. Here, I argue that the same Mott problem question should be asked about Geiger counters. I then define a simple experiment to determine if ionization physics similar to the cloud chamber case takes place in the mica window of a Geiger counter and explains the collimation of wavefunctions that are spherically symmetric outside the counter into linear ion tracks inside. The experiment measures the count rate from a radioactive point source as a function of source-window separation. I have performed a proof of concept of this experiment; results are reported here and support the near-singular-ionization picture. These results are significant in their own right, and they may shed light on physical mechanisms underlying instances of the full quantum measurement problem. I illustrate this for the Stern–Gerlach experiment and a particular realization of superconducting qubits. I conclude by detailing further work required to flesh out these results more rigorously.
Dominant mechanism in spinal cord injury-induced immunodeficiency syndrome (SCI-IDS): sympathetic hyperreflexia
Authors: Yang Ping , Bian Zhi-qun , Song Zhen-bo , Yang Cheng-ying , Wang Li , Yao Zhong-xiang 
Published: October 2023

Abstract
Clinical studies have shown that individuals with spinal cord injury (SCI) are particularly susceptible to infectious diseases, resulting in a syndrome called SCI-induced immunodeficiency syndrome (SCI-IDS), which is the leading cause of death after SCI. It is believed that SCI-IDS is associated with exaggerated activation of sympathetic preganglionic neurons (SPNs). After SCI, disruption of bulbospinal projections from the medulla oblongata C1 neurons to the SPNs results in the loss of sympathetic inhibitory modulation from the brain and brainstem and the occurrence of abnormally high levels of spinal sympathetic reflexes (SSR), named sympathetic hyperreflexia. As the post-injury survival time lengthens, mass recruitment and anomalous sprouting of excitatory interneurons within the spinal cord result in increased SSR excitability, resulting in an excess sympathetic output that disrupts the immune response. Therefore, we first analyze the structural underpinnings of the spinal cord-sympathetic nervous system-immune system after SCI, then demonstrate the progress in highlighting mechanisms of SCI-IDS focusing on norepinephrine (NE)/Beta 2-adrenergic receptor (β2-AR) signal pathways, and summarize recent preclinical studies examining potential means such as regulating SSR and inhibiting β2-AR signal pathways to improve immune function after SCI. Finally, we present research perspectives such as to promote the effective regeneration of C1 neurons to rebuild the connection of C1 neurons with SPNs, to regulate excitable or inhibitory interneurons, and specifically to target β2-AR signal pathways to re-establish neuroimmune balance. These will help us design effective strategies to reverse post-SCI sympathetic hyperreflexia and improve the overall quality of life for individuals with SCI.
The Epigenesis of Germs and Dispositions in Logic and Life: Kant’s System of Pure Reason and His Concept of Race
Authors: Ferrini Cinzia 
Published: October 2023

AbstractIn the 1787 Transcendental Deduction of the Categories Kant indicates the only possible ways by which one can account for a necessary agreement of experience with the concepts of its objects (B166), using analogies between modes of explanation and biological theories about the origin of life. He endorses epigenesis as a model for his system of pure reason (B167). This paper examines various interpretive claims about the meaning of this theory of generation and its significance for Kant’s philosophy (Section 1), showing that, after his Critical shift in perspective, in 1775/77 Kant already combined preformed elements and their purposively oriented formation by natural forces (Section 2). Contrary to the standard view, Kant’s theory of race appears to constitute the background to assess Blumenbach’s later (1799/1781) shift to epigenesis after supporting Haller’s preformism (Section 3). In Section 4, I argue that the ground of affinity between epigenesis and formal idealism rests in tracing the first origin of these conformities: externala posterioriclimate conditions and predisposed germs and dispositions within the generative power of the human body; and externala posterioriexperience and spontaneousa prioriconcepts of its objects, within pure sensory intuiting and pure thinking. In both cases the external empirical conditions would function as occasioning propelling factors affecting internal pre-established forms of generation.
A diploma értéke és konvertálásának lehetőségei a volt hallgatók véleménye alapján
Authors: Reisz Terézia 
Published: October 2023

A cikk a Felnőttképzési és Emberi Erőforrás Fejlesztési Kar egykori hallgatóinak az egyetemi éveket követő szakmai és személyes életének alakulását mutatja be. Ismerteti a diplomások társadalmi, szociokulturális hátterét, munkaerőpiaci viszonyait, egzisztenciális helyzetét és azok változását. Egyrészt arra fókuszál, hogy milyen egyéni késztetések vezették el őket a kar különféle képzéseire, másrészt azt világítja meg, hogy a diplomát miként értékelték és hasznosították a szakmai életpályájuk során. Kérdőíves és mélyinterjús kutatásunk során a 2006-ban és az azt megelőző három és fél évtizedben végzettek adatai alapján a 1267 fős, reprezentatív minta numerikus és szöveges információit vontuk be az adatbankunkba. Tanulmányunk az adatok másodelemzése alapján mutatja be a volt hallgatóink szakmai életútjával kapcsolatos tapasztalatainkat.
Manipulating Internal and External Loads During Repeated Cycling Sprints: A Comparison of Continuous and Intermittent Blood Flow Restriction
Authors: Mckee James R. , Girard Olivier , Peiffer Jeremiah J. , Scott Brendan R. 
Published: October 2023

Abstract
Mckee, JR, Girard, O, Peiffer, JJ, and Scott, BR. Manipulating internal and external loads during repeated cycling sprints: A comparison of continuous and intermittent blood flow restriction. J Strength Cond Res 38(1): 47–54, 2024—This study examined the impact of blood flow restriction (BFR) application method (continuous vs. intermittent) during repeated-sprint exercise (RSE) on performance, physiological, and perceptual responses. Twelve adult male semi-professional Australian football players completed 4 RSE sessions (3 × [5 × 5-second maximal sprints:25-second passive recovery], 3-minute rest between the sets) with BFR applied continuously (C-BFR; excluding interset rest periods), intermittently during only sprints (I-BFRWORK), or intraset rest periods (I-BFRREST) or not at all (Non-BFR). An alpha level of p < 0.05 was used to determine significance. Mean power output was greater for Non-BFR ( p < 0.001, d
z = 1.58 ), I-BFRWORK ( p = 0.002, d
z = 0.63 ), and I-BFRREST ( p = 0.003, d
z = 0.69 ) than for C-BFR and for Non-BFR ( p = 0.043, d
z = 0.55 ) compared with I-BFRREST. Blood lactate concentration ( p = 0.166) did not differ between the conditions. Mean oxygen consumption was higher during Non-BFR ( p < 0.001, d
z = 1.29 and 2.31; respectively) and I-BFRWORK (p < 0.001, d
z = 0.74 and 1.63; respectively) than during I-BFRREST and C-BFR and for I-BFRREST ( p = 0.002, d
z = 0.57) compared with C-BFR. Ratings of perceived exertion were greater for I-BFRREST ( p = 0.042, d
z = 0.51) and C-BFR ( p = 0.011, d
z = 0.90) than for Non-BFR and during C-BFR ( p = 0.023, d
z = 0.54) compared with I-BFRWORK. Applying C-BFR or I-BFRREST reduced mechanical output and cardiorespiratory demands of RSE and were perceived as more difficult. Practitioners should be aware that BFR application method influences internal and external demands during RSE.
Effect of Neuromuscular Fatigue on the Countermovement Jump Characteristics: Basketball-Related High-Intensity Exercises
Authors: Yoshida Nobuhisa , Hornsby W. Guy , Sole Christopher J. , Sato Kimitake , Stone Michael H. 
Published: October 2023

Abstract
Yoshida, N, Hornsby, WG, Sole, CJ, Sato, K, and Stone, MH. Effect of neuromuscular fatigue on the countermovement jump characteristics: basketball related high-intensity exercises. J Strength Cond Res XX(X): 000–000, 2023—The purpose of this study was to investigate basketball specific neuromuscular (NM) fatigue effect on countermovement jump (CMJ) force-time (F-T) curve characteristics. Eleven male college-level basketball athletes performed 6 CMJ trials at 3 baseline (pre) and 6 postexercise time points. The fatiguing protocol consisted of high-intensity basketball related exercises commensurate with basketball game or practice. Typical CMJ (CMJ-TYP) and phase-specific CMJ variables were derived from the F-T curve. Meaningful differences in CMJ performance were examined using effect size (ES) compared with baseline and previous postexercise time point. Baseline with 3 separated measurements demonstrated suitable CMJ variables reproducibility (CV, coefficient of variation). Most CMJ-TYP output and performance variables displayed substantial alterations immediately postexercise (0 hour) and returned to baseline at 24 hours postexercise, whereas the time and rate-related CMJ-TYP and CMJ-phase variables tended to display delayed decline peaked at 2 hours and delayed recovery to baseline at 48 hours postexercise. In conjunction with the return of the time and rate-related variables, CMJ performance displayed supercompensation at 72 hours postexercise. The results indicate altered NM functions with desired CMJ performance, such as jump height, which imply an altered movement strategy at early stage of recovery process. Full recovery may take 48–72 hours. Practitioners are, therefore, advised to monitor variables reflecting NM functions for precise manipulation of the intensity and volume of exercise to avoid prolonging the recovery from NM fatigue.
Intertextual Relations of Linguistics Articles with Other Texts
Authors: Kontutytė Eglė 
Published: October 2023

Scholarly text conventions are important when writing texts, especially in a foreign language. Intertextual relations with other texts are a characteristic feature of scientific language. As Lithuanian and foreign researchers point out, this is manifested by quoting, paraphrasing and summarizing. In examining the intertextuality of academic language, researchers also draw attention to its multilingualism. Based on the above-mentioned forms of intertextuality, this article analyses the intertextuality features of linguistics articles written in Lithuanian. The analysis shows that direct quotations in Lithuanian articles include short phrases or even full sentences from other authors’ texts imbedded in a sentence, with or without introductory phrases. In English, Polish or Russian, direct quotations can also be inserted into a sentence. Quotations from other languages are given with or without translation. Paraphrasing has been observed to be more frequently used, as the reformulated statements of other authors do not destroy the linguistic integrity and cohesion of the text. This is especially useful when quoting texts in other languages.
A reference is one in which the text does not directly or indirectly reproduce the statements of other authors, but merely refers in some way to previous research. Scholarly terms from other languages, usually English, presented as equivalents of other languages together with the Lithuanian term or even without it., may be treated as a case of multilingual intertextuality. Although precision is often pointed out as a feature of academic language, the linguistics articles analyzed show many instances of paraphrasing and referential intertextuality. Such intertextual interfaces substantiate the research presented in the article or the scientific issues raised, establish their place within a wider range of sources, and convey the author’s thought in a condensed way in the language of the publication, without breaking the typographic and linguistic unity of the text. Multilingual intertextuality shows that it is important for researchers of the Lithuanian language, who publish their texts in Lithuanian, to locate their research in the international context of linguistics and to establish a scientific dialogue with researchers of other countries and languages.