bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability
Authors: Takechi-Haraya Yuki , Ohgita Takashi , Usui Akiko , Nishitsuji Kazuchika , Uchimura Kenji , Abe Yasuhiro , Kawano Ryuji , Konaklieva Monika I. , Reimund Mart , Remaley Alan T. , Sato Yoji , Izutsu Ken-ichi , Saito Hiroyuki 
Published: November 2023

AbstractAmphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide while focusing on structural flexibility. We designed conformationally constrained versions of A2-17, stapled (StpA2-17) and stitched (StchA2-17), whose α-helical conformations were stabilized by chemical crosslinking. Circular dichroism confirmed that StpA2-17 and StchA2-17 had higher α-helix content than A2-17 in aqueous solution. Upon liposome binding, only A2-17 exhibited a coil-to-helix transition. Confocal microscopy revealed that A2-17 had higher cell penetration efficiency than StpA2-17, whereas StchA2-17 remained on the cell membrane without cell penetration. Although the tryptophan fluorescence analysis suggested that A2-17 and its analogs had similar membrane-insertion positions between the interface and hydrophobic core, StchA2-17 exhibited a higher membrane affinity than A2-17 or StpA2-17. Atomic force microscopy demonstrated that A2-17 reduced the mechanical rigidity of liposomes to a greater extent than StpA2-17 and StchA2-17. Finally, electrophysiological analysis showed that A2-17 induced a higher charge influx through transient pores in a planer lipid bilayer than StpA2-17 and StchA2-17. These findings indicate that structural flexibility, which enables diverse conformations of A2-17, leads to a membrane perturbation mode that contributes to cell membrane penetration.
Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women
Authors: Liang Ching-Chung , Hsieh Wu-Chiao , Lo Tsia-Shu , Huang Ting-Xuan , Chou Yi-Chun , Huang Jing-Yi , Huang Yung-Hsin 
Published: November 2023

AbstractThis study was to investigate urinary beta 3-adrenoceptor concentration as a biomarker for overactive bladder (OAB) and predictor of treatment outcomes in women receiving the beta 3-adrenoceptor agonist mirabegron. The study comprised 50 women identified with OAB and 35 women considered as healthy controls. All women with OAB received daily dosage of 50 mg of mirabegron for 12 weeks. Bladder diaries, OAB-related questionnaires, and global response assessment scale (GRAS) data were collected. Urinary beta 3-adrenoceptor concentration was measured through enzyme-linked immunosorbent assay. All OAB-related questionnaires and GRAS indicated improved posttreatment urinary health. After mirabegron treatment, the frequency of micturition and urgency episodes decreased, but the urinary beta 3-adrenoceptor/creatinine (Cr) ratio increased. The urinary beta 3-adrenoceptor/creatinine ratio was identified as a sensitive biomarker for OAB with a confidence interval of 0.656 to 0.856 (p < 0.001). A negative correlation (− 0.431, p = 0.040) between this biomarker and health-related quality of life (HRQL) scores. The Beta 3-adrenoceptor/Cr levels increased significantly in the treatment-responsive group, while they remained unchanged in the unsatisfactory outcome group. This study shows that 12 weeks of mirabegron treatment improves OAB symptoms and HRQL. Furthermore, urinary beta 3-adrenoceptor concentration may be a diagnostic biomarker for OAB.
Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study
Authors: Fu Chong , Chen Yan , Xu Wei , Zhang Yanping 
Published: November 2023

AbstractTo further evaluate the causal relationships between inflammatory cytokines and migraine, we conducted a bidirectional, two-sample Mendelian randomization (MR) analysis using genetic data from publicly available genome-wide association studies (GWAS). We used several MR methods, including random-effect inverse-variance weighting (IVW), weighted median, MR-Egger, to test the causal relationships. Sensitivity analyses were also conducted to evaluate the robustness of the results. The results showed that hepatocyte growth factor (HGF) was positively associated with the risk of migraine (odds ratio [OR], 1.004; 95% confidence interval [CI], 1.001–1.008; P = 0.022). In addition, Interleukin-2 (IL-2) was considered a downstream consequence of migraine (OR, 0.012; 95% CI, 0.000–0.0929; P = 0.046). These findings suggest that HGF may be a factor associated with the etiology of migraine, while IL-2 is more likely to be involved in the downstream development of migraine.
Spatio-temporal divergence and influencing factors of agritourism integration development in Xinjiang, China
Authors: Peng Yaping , Liu Weizhong , Xiong Changjiang 
Published: November 2023

AbstractExploring the coupling and coordination relationship between agriculture and tourism industry plays an important role in formulating differentiated integration development policies and promoting regional economic development. We adopt 14 prefectures and cities in Xinjiang, China as examples, and use a coupling coordination model and generalized method of moments estimation to explore the spatial differentiation characteristics and influencing factors between agriculture and tourism industries in various prefectures and cities in Xinjiang from 2009 to 2018. The results indicate: (1) The combined development levels of agriculture and tourism in Xinjiang exhibited a similar development trend over the period, and despite fluctuations in individual years, the overall trend is still increasing. (2) The coupling degree and coordination of agriculture and tourism in various regions presented significant spatial differentiation characteristics. (3) Human capital, residents’ consumption level, and coupling coordination degree are positively correlated, while service capacity, government support, industrial foundation, and market supply and coupling coordination degree are significantly negatively correlated. Finally, based on our results, we present corresponding suggestions on how to improve the level of integrated development of agriculture and tourism in Xinjiang.
Efficacy of second-line chemotherapy after treatment with gemcitabine plus nab-paclitaxel or FOLFIRINOX in patients with metastatic pancreatic cancer
Authors: Fukahori Masaru , Okabe Yoshinobu , Shimokawa Mototsugu , Otsuka Taiga , Koga Futa , Ueda Yujiro , Nakazawa Junichi , Komori Azusa , Otsu Satoshi , Arima Shiho , Makiyama Akitaka , Taguchi Hiroki , Honda Takuya , Ushijima Tomoyuki , Miwa Keisuke , Shibuki Taro , Nio Kenta , Ide Yasushi , Ureshino Norio , Mizuta Toshihiko , Mitsugi Kenji , Shirakawa Tsuyoshi 
Published: November 2023

AbstractFirst-line chemotherapy for patients with metastatic pancreatic cancer (MPC) includes gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX). However, the efficacy of second-line chemotherapy and the role of combination chemotherapy in clinical practice is still unknown. Data was gathered from 14 hospitals in the Kyushu area of Japan from December 2013 to March 2017. The median overall survival (mOS) from second-line treatment was contrasted between patients who received second-line chemotherapy (CT group) and those who received the best supportive care (BSC group). Furthermore, the mOS of combination chemotherapy was compared to mono chemotherapy in the CT group. To control possible bias in the selection of treatment, we performed a propensity score-adjusted analysis. A total of 255 patients received GnP or FFX as first-line chemotherapy. There were 156 in the CT group and 77 in the BSC group of these. The CT group had a significantly longer mOS than the BSC group (5.2 vs. 2.6 months; adjusted hazard ratio (HR) 0.38; 95% CI 0.27–0.54). In the CT group, 89 patients received combination chemotherapy while 67 received mono chemotherapy. The mOS did not differ significantly between the combination and mono chemotherapy groups (5.5 vs. 4.8 months; adjusted HR 0.88; 95% CI 0.58–1.33). Among patients with MPC receiving second-line treatment, the CT group had a significantly longer mOS than the BSC group, but combination chemotherapy conferred no improvement in survival compared to mono chemotherapy.
Prenatal folic acid and vitamin B12 imbalance alter neuronal morphology and synaptic density in the mouse neocortex
Authors: Tat Lyvin , Cannizzaro Noemi , Schaaf Zachary , Racherla Shailaja , Bottiglieri Teodoro , Green Ralph , Zarbalis Konstantinos S. 
Published: November 2023

AbstractPrevious reports have provided evidence that insufficient or excessive maternal folic acid (FA) intake during pregnancy can alter neurodevelopment of the offspring by modulating prenatal neurogenesis. Furthermore, our earlier work in a mouse model confirmed long-term structural changes at the cellular level of either deficient or excessive FA supply by comparably reducing dendritic arborization of cortical projection neurons. Here, we report that excessive amounts of FA decrease arborization of deep layer projection neurons, but not upper layer neurons and that reduced complexity of deep layer neurons is not observed when folic acid is replaced by folinic acid, a stable reduced form of folate. In addition, deficiency of B12, a vitamin that critically regulates folate metabolism, causes even more marked decreases in neuronal arborization in both deep and upper layer neurons and particularly in combination with FA excess. Furthermore, both FA excess and B12 deficiency affect synaptic density and morphology. Our findings point to neurodevelopmental risks associated with insufficient amounts of prenatal B12, particularly in association with high levels of FA intake, suggesting that the neurodevelopmental program is sensitive to an imbalance in the status of these interacting micronutrients.
Macrophage-hitchhiked arsenic/AB bionic preparations for liver cancer
Authors: Li Ce , Zhang Ji Ping , Yuan Yi Chao , Zhao Yong Qin , Zheng Hang Sheng , Zhu Zhi Hong 
Published: November 2023

Arsenic/AB could be effectively delivered to deep tumor by using the tumor-homing tendency of macrophages in vivo. And it could induce TAM differentiation into an anti-tumor M1 phenotype by inhibiting the secretion of CSF1 and IL-6.
Empowering young learners to explore blockchain with user‐friendly tools: a method using Google Blockly and NFTs
Authors: Tsai Yun‐Cheng , Huang Jiun‐Yu , Chiou Da‐Ru 
Published: November 2023

AbstractThis paper presents a novel architecture utilizing blockchain technology to enhance educational systems. A method is proposed that empowers non‐fungible tokens by updating their metadata through an API layer, making blockchain technology more accessible to K‐12 students. Leveraging Google Blockly, a visual programming language, the aim is to engage students in computational thinking and foster their understanding of blockchain concepts. The approach promotes student engagement, facilitates the comprehension of digital ownership and value, and develops essential skills for the digital age. Through the method, the contribution is in the advancing of blockchain in education. The demo video can be seen using the following link, https://youtu.be/ZPVKgWtSb6U.
EN‐DADA: Node task assignment algorithm for energy harvesting wireless multimedia sensor networks
Authors: Han Chong , Ding Leilei , Guo Jian , Sun Lijuan 
Published: November 2023

AbstractToday, a directional wireless multimedia sensor network is a popular environment for solving the task assignment problem. Achieving long‐term frontal monitoring of moving objects is a crucial challenge for scholars in this field. Utilizing directional sensors equipped with energy harvesting is an effective technique to enhance network performance. In this way, the energy of nodes is no longer limited to batteries and can result in better frontal monitoring. In this method, each sensor categorizes tasks based on its own energy, allowing the determination of task execution nodes through bidding. The present study proposes a distributed algorithm for directional task assignment, EN‐DADA, based on energy harvesting. The task was first classified to determine the candidate node set that could execute the task, and then the task assignment was determined according to the monitoring income of each node in the candidate node set. The comparative analysis confirmed that the proposed method had advantages in terms of task revenue and network lifetime when using the same energy harvesting model.
Single‐image deraining algorithm based on multi‐stage recurrent network
Authors: Li Chen , Li Xueting , Guo Yecai , Li Jia 
Published: November 2023

AbstractThe damage caused by the rain streak attached to the rainy image to the background seriously affects the analysis of image information and subsequent research. Aiming at the problem that the current single image rain removal methods cannot extract the deep rain streak features, a single image deraining algorithm based on multi‐stage recurrent network is proposed, which is committed to separating the rain streak layer and the background layer. The network consists of three stages, each stage is mainly composed of upper and lower scale dilation blocks, the upper scale dilation block includes multi‐scale dilated convolution and scale fusion, the lower scale dilation block is set the same, and the stages are connected using improved gated recurrent units to facilitate parameter sharing between them. The experimental results show that the proposed algorithm outperforms the comparative algorithm in both quantitative indicators and qualitative analysis on synthetic and real datasets, and the restored image retains more detailed information.
LINC00092 Enhances LPP Expression to Repress Thyroid Cancer
Development via Sponging miR-542-3p
Authors: Wang Huan 
Published: November 2023

AbstractLINC00092 is poorly expressed in Thyroid cancer (TC), while its role in TC
tumorigenesis is still elusive. This study aimed to reveal the role and
regulatory mechanism of LINC00092 in TC.RNA immunoprecipitation and dual luciferase reporter assays were employed to
ascertain the relationships among lipoma preferred partner (LPP), miR-542-3p,
and LINC00092. qRT-PCR analysis was performed to detect their expression levels
in TC. LPP protein productions were evaluated via western blotting. CCK-8,
transwell, and colony formation assays were done to estimate TC cells’
biological functions. A murine xenograft model was built to observe tumor
formation in vivo.LINC00092 overexpression decreased the expression levels of miR-542-3p, and LPP
was targeted by miR-542-3p. In TC cells and tissues, the elevation of
miR-542-3p, and low amounts of LINC00092 and LPP can be observed. Both LINC00092
and SPAG6 were considered as the antineoplastic factors in TC since their
overexpression dramatically repressed TC cells’ invasive and
proliferative potentials, while miR-542-3p exerted the opposite functions in TC.
The ectopic expression of LINC00092 also suppressed tumor growth in vivo. In
addition, it revealed that miR-542-3p upregulation reversed LINC00092
overexpression-mediated effects on TC cells. At the same time, the enhanced
influences of TC cells caused by miR-542-3p upregulation could be attenuated by
the enforced LPP.This study innovatively reveals that LINC00092 acts as an antineoplastic lncRNA
to restrain the development of TC via regulating miR-542-3p/LPP. The
findings of this study may provide a prospective drug target on
LINC00092/miR-542-3p/LPP axis for the treatment of TC.
Intrathecal Therapy Options for Meningeal Carcinomatosis
Authors: Marowsky Madeleine , Müller Volkmar , Schmalfeldt Barbara , Riecke Kerstin , Witzel Isabell , Laakmann Elena 
Published: November 2023

AbstractAround 5 percent of all patients with metastatic breast cancer go on to develop distant metastases in the meninges, also known as meningeal carcinomatosis. The median survival of these
patients is between 3.5 and 4.5 months. Current treatment approaches are based on radiotherapy, systemic and intrathecal therapy. Methotrexate, liposomal cytarabine and trastuzumab are the
most common substances used for intrathecal therapy. The aim of this review was to provide an overview of these intrathecal therapy options for meningeal carcinomatosis. A systematic search
of the literature was carried out in PubMed using the following search terms: “meningeal metastases”, “meningeal carcinomatosis”, “leptomeningeal metastasis”, “leptomeningeal
carcinomatosis”, “leptomeningeal disease”, “breast cancer”, “MTX”, “methotrexate”, “DepoCyte”, “liposomal cytarabine”, “trastuzumab” and “anti-HER2”. This search resulted in 75 potentially
relevant studies, 11 of which were included in this review after meeting the previously determined inclusion and exclusion criteria. The studies differ considerably with regards to study
design, cohort size, and dosages of administered drugs. In principle, intrathecal therapy has a tolerable side-effects profile and offers promising results in terms of the median overall
survival following treatment with trastuzumab for HER2-positive primary tumors. The focus when treating meningeal carcinomatosis must be on providing a multimodal individual therapeutic
approach. However, comprehensive studies which compare the efficacy and side effects of individual pharmaceuticals are lacking. Because of the poor prognosis associated with meningeal
carcinomatosis, an approach which treats only the symptoms (best supportive care) should always be considered and discussed with affected patients.
Differences between hemispheres and in saccade latency regarding volleyball athletes and non-athletes during saccadic eye movements: an analysis using EEG
Authors: Vicente Renan , Bittencourt Juliana , Costa Élida , Nicoliche Eduardo , Gongora Mariana , Di Giacomo Jessé , Bastos Victor Hugo , Teixeira Silmar , Orsini Marco , Budde Henning , Cagy Mauricio , Velasques Bruna , Ribeiro Pedro 
Published: November 2023

Abstract
Background The saccadic eye movement is responsible for providing focus to a visual object of interest to the retina. In sports like volleyball, identifying relevant targets quickly is essential to a masterful performance. The training improves cortical regions underlying saccadic action, enabling more automated processing in athletes.
Objective We investigated changes in the latency during the saccadic eye movement and the absolute theta power on the frontal and prefrontal cortices during the execution of the saccadic eye movement task in volleyball athletes and non-athletes. We hypothesized that the saccade latency and theta power would be lower due to training and perceptual-cognitive enhancement in volleyball players.
Methods We recruited 30 healthy volunteers: 15 volleyball athletes (11 men and 4 women; mean age: 15.08 ± 1.06 years) and 15 non-athletes (5 men and 10 women; mean age: 18.00 ± 1.46 years). All tasks were performed simultaneously with electroencephalography signal recording.
Results The latency of the saccadic eye movement presented a significant difference between the groups; a shorter time was observed among the athletes, associated with the players' superiority in terms of attention level. During the experiment, the athletes observed a decrease in absolute theta power compared to non-athletes on the electrodes of each frontal and prefrontal area.
Conclusion In the present study, we observed the behavior of reaction time and absolute theta power in athletes and non-athletes during a saccadic movement task. Our findings corroborate the premise of cognitive improvement, mainly due to the reduction of saccadic latency and lower beta power, validating the neural efficiency hypothesis.
Correlation of Venous Blood Sugar Measured by Lab Method and Capillary Blood Sugar Measured by Glucometer in Neurosurgical Patients Receiving Dexamethasone
Authors: Sharma Jyoti , Bala Renu , Singh Seema 
Published: November 2023

Abstract
Background Brain is vulnerable to extreme blood glucose levels that may occur due to multiple factors in neurosurgical patients; perioperative use of dexamethasone is the most common. Thus, frequent monitoring of blood sugar levels is advocated. This study aimed to assess correlation between venous blood sugar measured by lab method and capillary blood sugar by glucometer at various time intervals.
Materials and Methods This prospective and observational study was conducted in 20 adult patients of either sex, American Society of Anesthesiologists grade I to III, scheduled to undergo brain tumor resection. The patients who were already on dexamethasone and received intraoperatively 8 mg dexamethasone were enrolled. Standard anesthesia technique and intraoperative monitoring were followed in all patients. Venous sample was withdrawn and blood sugar analyzed in laboratory, while at the same time capillary blood sugar was tested by glucometer. The sampling was done at baseline, 1 hourly after dexamethasone administration till 4 hours and then 8, 12, and 24 hours. The correlation between the two values was assessed.
Results During the study, 160 venous and 160 capillary blood sugar levels were analyzed. Though capillary blood sugar levels were slightly higher than venous sugar levels, there was strong correlation between the two (Pearson correlation coefficient) with p-value less than 0.05 except at 24 hours when two values were not correlated.
Conclusion Capillary blood sugar levels by glucometer have good correlation with venous sugar levels; therefore, this method may be adopted routinely for frequent blood sugar estimation as it is reliable, easy, and practical.
Rete Middle Cerebral Artery Aneurysm: A Case Report and Systematic Review
Authors: Cavalcante-Neto Joaquim Francisco , Monteiro Gabriel de Almeida , Brandt Ariane Butke , Soares Giovanna Esmeraldo Paz , Solla Davi Jorge Fontoura , Leal Paulo Roberto Lacerda , Cristino-Filho Gerardo , da Ponte Keven Ferreira 
Published: November 2023

Abstract
Background Middle cerebral artery (MCA) anomalies are a rare finding and may be associated with vascular changes, such as intracranial aneurysms. Among them, the rete MCA aneurysm is very rare, with only 22 cases reported to date.
Case Description A 50-year-old woman presented with subarachnoid, intraventricular, and intracerebral hemorrhage secondary to a ruptured aneurysm of rete MCA from an anomalous collateral artery of the anterior cerebral artery, treated successfully by microsurgical clipping. She presented a good recovery after a 2-year follow-up.
Conclusion A systematic review of rete MCA aneurysms is presented, comparing aneurysms originating from twig-like MCA, with 16 reports, and twig-like networks of an anomalous collateral artery, with 6 reports including ours. Several factors influence the treatment decision-making, though microsurgical clipping is the main procedure. A wider use of coiling is requested for a better comparison of the treatment approaches.