bluuebunny/crossref_metadata_2025_split huggingface dataset:
Лечение диффузной В-крупноклеточной лимфомы в условиях ГКБ № 52 Департамента здравоохранения Москвы: ретроспективное клиническое исследование, отражающее опыт одного центра, на основе анализа данных из собственного локального регистра
Authors: Мингалимов Марат Альбертович , Барях Е. А. , Поляков Ю. Ю. , Мисюрина Е. Н. , Желнова Е. И. , Яцков К. В. , Макешова А. Б. , Толстых Т. Н. , Чуднова Т. С. , Иванова Д. Д. , Кочнева О. Л. , Самсонова И. В. , Лысенко М. А. 
Published: February 2024

Background. The term diffuse large B-cell lymphoma (DLBCL) defines a heterogeneous group of lymphatic tumors. DLBCL is the most frequent immunomorphological variant among aggressive non-Hodgkin lymphomas (NHLs) in adults. It accounts for 30–40 % of all NHLs. Long-term results of treating newly diagnosed DLBCL have not been reliably evidenced in healthcare practice and, therefore, require further study.
Aim. To assess the efficacy of chemotherapy for newly diagnosed DLBCL in terms of the 5-year progression-free survival (PFS) based on the analysis of data from the in-house hematology service registry at the Moscow City Clinical Hospital No. 52.
Materials & Methods. The study enrolled 156 patients with newly diagnosed DLBCL in the period from 2015 to 2022. The patients were 35–85 years of age (median 65 years).
Results. First-line R-CHOP/R-miniCHOP chemotherapy was administered to 70 % of patients, 28 % of patients received R-DA-EPOCH, and 2 % were treated either with R-B or R-CVP. Complete response was achieved in 100 (65 %) patients: 75 out of them (75 %) received R-CHOP/R-miniCHOP, whereas 25 (25 %) received R-DA-EPOCH. Induction mortality was below 2.5 %. The 5-year PFS was 32 % with the survival median of 20 months. As confirmed by the multivariate analysis, the age over 60 years (p = 0.003), high IPI risk group (p = 0.015), advanced stage of the disease (p = 0.002), and non-GCB subtype of tumor (p = 0.045) can be regarded as independent predictors of early DLBCL progression.
Conclusion. DLBCL is an aggressive B-cell lymphoma and one of the most frequent immunomorphological NHL variants in the clinical practice of the Moscow City Clinical Hospital No. 52. Despite the use of generally accepted standard immunochemotherapy regimens, the results attained by the present study illustrate unresolved challenges in chemotherapy for newly diagnosed DLBCL patients. By now, more effective first-line DLBCL therapy methods already exist, which are confirmed by the results of clinical trials. As it is sometimes impossible to further escalate immunochemotherapy for obvious reasons (age restrictions, health status, co-morbidities, etc.), a new promising strategy appears to be the personalized chemotherapy based on the study of genetic DLBCL profile of each particular patient.
Discrimination between scheduled and non-scheduled groups in access to basic services in urban India
Authors: Arora Tarun , Choudhary Prashant Kumar 
Published: February 2024

Abstract
Access to basic services such as water, sanitation, and electricity is a key determinant of an individual's well-being. Nevertheless, access to these services is unequally distributed among different social groups in many countries. India is no exception, with the scheduled castes (SC) and scheduled tribes (ST) being one of the country's most marginalised and disadvantaged groups. This paper analyses the disparities in access to basic services between scheduled and non-scheduled households, investigates the factors contributing to the unequal access, and suggests policy recommendations. Using data from the National Sample Survey 76th Round, we analyse the access to basic services such as durable housing, improved water and sanitation, and access to electricity. The paper's objectives are (a) to investigate the factors impacting the quality of basic service delivery in urban India separately for scheduled and non-scheduled households and (b) to quantify the discrimination between scheduled and non-scheduled households in urban India concerning access to quality of basic services through computing a comprehensive index and by using the ‘Fairlie decomposition’ approach. The analysis corroborates the finding that systemic discrimination exists between scheduled and non-scheduled households in urban India regarding access to good quality basic services up to an extent of 24%.
Effect of Negative Online Reviews and Physician Responses on Health Consumers’ Choice: Experimental Study
Authors: Han Xi , Lin Yongxi , Han Wenting , Liao Ke , Mei Kefu 
Published: February 2024

Background
The COVID-19 pandemic has highlighted the importance of online medical services. Although some researchers have investigated how numerical ratings affect consumer choice, limited studies have focused on the effect of negative reviews that most concern physicians.

Objective
This study aimed to investigate how negative review features, including proportion (low/high), claim type (evaluative/factual), and physician response (absence/presence), influence consumers’ physician evaluation process under conditions in which a physician’s overall rating is high.

Methods
Using a 2×2×2 between-subject decision-controlled experiment, this study examined participants’ judgment on physicians with different textual reviews. Collected data were analyzed using the t test and partial least squares–structural equation modeling.

Results
Negative reviews decreased consumers’ physician selection intention. The negative review proportion (β=–0.371, P<.001) and claim type (β=–0.343, P<.001) had a greater effect on consumers’ physician selection intention compared to the physician response (β=0.194, P<.001). A high negative review proportion, factual negative reviews, and the absence of a physician response significantly reduced consumers’ physician selection intention compared to their counterparts. Consumers’ locus attributions on the negative reviews affected their evaluation process. Physician attribution mediated the effects of review proportion (β=–0.150, P<.001), review claim type (β=–0.068, P=.01), and physician response (β=0.167, P<.001) on consumer choice. Reviewer attribution also mediated the effects of review proportion (β=–0.071, P<.001), review claim type (β=–0.025, P=.01), and physician response (β=0.096, P<.001) on consumer choice. The moderating effects of the physician response on the relationship between review proportion and physician attribution (β=–0.185, P<.001), review proportion and reviewer attribution (β=–0.110, P<.001), claim type and physician attribution (β=–0.123, P=.003), and claim type and reviewer attribution (β=–0.074, P=.04) were all significant.

Conclusions
Negative review features and the physician response significantly influence consumer choice through the causal attribution to physicians and reviewers. Physician attribution has a greater effect on consumers’ physician selection intention than reviewer attribution does. The presence of a physician response decreases the influence of negative reviews through direct and moderating effects. We propose some practical implications for physicians, health care providers, and online medical service platforms.
Mobile Intervention to Address Cannabis Use Disorder Among Black Adults: Protocol for a Randomized Controlled Trial
Authors: Nizio Pamella , Clausen Bryce , Businelle Michael S , Ponton Natalia , Jones Ava A , Redmond Brooke Y , Buckner Julia D , Obasi Ezemenari M , Zvolensky Michael J , Garey Lorra 
Published: February 2024

Background
African American or Black (hereafter referred to as Black) adults who use cannabis use it more frequently and are more likely to meet criteria for cannabis use disorder (CUD) than both White and Hispanic or Latin individuals. Black adults may be more apt to use cannabis to cope with distress, which constitutes a false safety behavior (FSB; a behavior designed to reduce psychological distress in the short term). Although FSB engagement can perpetuate the cycle of high rates of CUD among Black individuals, limited work has applied an FSB elimination treatment approach to Black adults with CUD, and no previous work has evaluated FSB reduction or elimination in the context of a culturally tailored and highly accessible treatment developed for Black individuals.

Objective
This study aims to develop and pilot-test a culturally tailored adaptive intervention that integrates FSB reduction or elimination skills for cannabis reduction or cessation among Black adults with probable CUD (Culturally Tailored-Mobile Integrated Cannabis and Anxiety Reduction Treatment [CT-MICART]).

Methods
Black adults with probable CUD (N=50) will complete a web-based screener, enrollment call, baseline assessment, 3 daily ecological momentary assessments (EMAs) for 6 weeks, and a follow-up self-report assessment and qualitative interview at 6 weeks after randomization. Participants will be randomized into 1 out of the 2 conditions after baseline assessment: (1) CT-MICART+EMAs for 6 weeks or (2) EMAs only for 6 weeks.

Results
The enrollment started in June 2023 and ended in November 2023. Data analysis will be completed in March 2024.

Conclusions
No culturally tailored, evidence-based treatment currently caters to the specific needs of Black individuals with CUD. This study will lay the foundation for a new approach to CUD treatment among Black adults that is easily accessible and has the potential to overcome barriers to treatment and reduce practitioner burden in order to support Black individuals who use cannabis with probable CUD.

Trial Registration
ClinicalTrials.gov NCT05566730; https://clinicaltrials.gov/study/NCT05566730

International Registered Report Identifier (IRRID)
DERR1-10.2196/52776
Orthosiphon stamineus Benth, a potential herb in treatment of gout: A mini opinion and call for further research
Authors: Le Quang-Ung , Hoang Duc-Thuan 
Published: February 2024

Based on our knowledge, experience and field survey in the treatment of gout by complementary/alternative medicine and especially the herb therapy, properties of curing gout of Orthosiphon stamineus Benth are briefly commented and suggest that the future research to insightfully educidate this science opinion is necessary.
Keywords: Orthosiphon stamineus, gout, alternative medicine
Pharmacological Targeting of Ferroptosis in Cancer Treatment
Authors: Khan Mohammad Altaf , Satapathy Trilochan , Sen Kalpana , Sahu Shailesh , Pradhan Bharti , Gupta Ayushi , Satapathy Abinash , Satapathy Ansuman 
Published: February 2024

A non-apoptotic iron-dependent form of Regulated Cell Death (RCD) known as ferroptosis is brought on by an excess of harmful lipid peroxides and iron overload. Inhibiting the antioxidant defense system results in overwhelming of GSH dependent pathway and building up iron-dependent Reactive Oxygen Species (ROS) that react with polyunsaturated fatty acids in large quantities can both cause ferroptosis. Recent research has shown that ferroptosis holds a great deal of promise for preventing tumor cell resistance and limiting growth and spread. Emerging evidence also suggests that ferroptosis plays a dual role in human cancer. However, the precise underlying molecular mechanisms and their different role in tumorigenesis are unclear. Therefore, in this review we summarize and briefly present the key pathways of ferroptosis, its dual role as an oncogenic and as a tumor suppressor event in human cancers, paying special attention to the regulation of ferroptosis along with a variety of current medications and naturally occurring substances that may one day be used to target ferroptosis in tumor cells. Thus, addressing this sort of cell death could be seen as a potentially expanding technique in cancer treatment. Consequently, this will offer crucial viewpoints for next research on ferroptosis-based cancer treatment.
Keywords: Ferroptosis, antioxidant defense system, Cancer
Ethyl acetate extract of breadfruit leaves (Artocarvus altilis) improves lipid profile and reduces F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus)
Authors: Dewi Shinta Eka Kusuma , Wiraguna Anak Agung Gde Putra , Pinatih Gde Ngurah Indraguna 
Published: February 2024

Dyslipidemia is closely related to the process of lipid peroxidation. In the non-enzymatic peroxidation process of arachidonic acid, an esterification process occurs and produces a metabolite in the form of isoprostane. The most common isoprostane found is F2-isoprostane. In traditional medicine, breadfruit leaves (Artocarvus altilis) have been widely used due to their antioxidant compounds, such as flavonoids, phenols, tannins, saponins, and other secondary metabolites. This study aims to evaluate the activity of breadfruit leaf ethyl acetate extract in improving the lipid profile and F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus). This study was an experimental study with a pretest-posttest control group design with two treatment groups: fenofibrate 1.65 mg (P1) and breadfruit leaf ethyl acetate extract (760 mg) (P2) for 28 days. Total cholesterol, triglyceride, HDL, LDL, and F2-isoprostane levels were measured before and after treatment expressed in mg/dL. The data were analyzed using a parametric t-paired and t-unpaired test with a 95% confidence level. The study found that breadfruit leaf extract was better than fenofibrate at lowering total cholesterol (pre 172.41 ± 4.93; post 101.24 ± 2.09), triglycerides (pre 172.41 ± 4.93; post 101.24 ± 2.09), LDL (pre 95.78 ± 8.00; post 12.03 ± 10.06), F2-Isoprostane (pre 924.86±10.40; post 432.99±14.17), and raising HDL (pre 102.29 ± 10.40; post 143.89 ± 5.99). In conclusion, ethyl acetate extract is better than fenofibrate in improving lipid profiles and reducing F2-isoprostane in dyslipidemia-induced animal tests.
Keywords: breadfruit leaves (Artocarvus altilis), dyslipidemia, F2-Isoprostane, fenofibrate, lipid profile, total cholesterol
Design, Evaluation and Optimization of Albuterol Sulphate and Theophylline Pulsincap drug delivery system for chronotherapy of Asthma
Authors: Reddy G. Govinda , Jat Rakesh Kumar , Manjanna K M 
Published: February 2024

The aim of the current study was to design and develop and evaluate pulsatile drug delivery system of Albuterol Sulphate and Theophylline for the treatment of Asthma. The capsule body was made water insoluble by cross linked with formaldehyde vaopur. The treatment of Formalin was adopted to modify the gelatin capsule solubility. The formalin residue was carried out by quantitative test. The drug-excipient compatibility is done by FTIR and UV . The pulsincap formulation were prepared by using hydrogel plug of various components. The drug content of the formulation of pulsincap was found to be in the general range. The invitro drug release studies in ph1.2 .6.2 and 7.4 buffern was noticed to be zero percent and capsule was stable for 2 hours drug the studyF5 formulation batch was selected which was best and good formulation and promoted maximum drug release of 96.29% percentage at phosphate buffers when compared with other formulation. Pulsincap formulation can be adopted for optimum delivery of pellets in the treatment as per chronotherapy
Keywords: Theophylline, quantitative test, invitro drug release studies, phosphate buffers6.2 and 7.4.
Contrasting Evidences Between High Cholesterol Levels and The Risk of Cardiovascular Disease: A Review
Authors: Saleh Ahmadu , Esievo King Akpofure Nelson 
Published: February 2024

Introduction: The cholesterol hypothesis had been kept alive for decades by reviewers who used statistics that excluded the results from unsuccessful trials and ignored numerous contradictory observations. High dietary cholesterol intake had been associated with development of cardiovascular diseases (CVD) and mortality, for over several decades, without a direct link between the CVD and high serum cholesterol level. Hence, people avoided healthy cholesterol-rich diets due to the fear of developing CVD. The relationship between elevated plasma cholesterol and CVD and criteria for appropriate methods for screening patients with elevated cholesterol had remained a source of medical debates. Lack of decrease in overall mortality rates in patients without clinical coronary disease in whom aggressive lowering of cholesterol was achieved might have contributed to the lack of consensus on this most important issue.
Methodology: With information derived from search engines, such as Elsevier, Springer, PubMed, Science Direct, Medline, Google Scholar and a library search for articles published in peer-reviewed journals.
Results: Several research results showed that association between total serum cholesterol, its components and CVD is weak, absent or inverse implying that consuming healthy high cholesterol diets may not be harmful to health.
Conclusion: This review provides evidence contrasting the links between elevated plasma cholesterol and CVD, and demonstrated that elevated cholesterol concentrations, rather, improve quality of life and life expectancy. In addition, most prevalent methods for cholesterol quantification in biological samples and foods, utilizing new technologies, such as Ambient Ionization Mass Spectrometry are summarized, along with other components of cholesterol.
Keywords: Cholesterol, CVD, Quantification
A Case Report on Iatrogenic Cushing Syndrome with Diabetes Mellitus
Authors: Sinwal Aashutosh , Kushwaha Aman , Ranjan Gyan , RAM Ratana , Upadhayay Kalpana , Choudhary Mukesh , Bhardwaj Mudit 
Published: February 2024

Cushing syndrome (CS) is a condition caused due to high levels of cortisol in which weight gain and fat tissue build-up take place. Generally, patients with Cushing syndrome also suffer from diabetes. A 57-year-old female patient with aggravated cortisol levels. Laboratory investigations of the patient were performed and they showed decreased haemoglobin levels, but increased vitamin B12 levels, and TSH levels. The patient was prescribed a combination of medications to manage anemia, anemia, and diabetes. The patient's medical history included splenomegaly, cholelithiasis, panniculitis, and kidney enlargement. The patient's diabetes was responding well to the treatment and was better after 10 days.
Keywords: Cushing syndrome, Diabetes mellitus, corticosteroid.
Visualizar principales características y métodos de la delincuencia informática, a partir de la lucha mundial contra el COVID-19
Authors: Gutiérrez Oquendo Henry 
Published: February 2024

By means of the proposed objective; to visualize the main characteristics and methods of computer crime, based on the global fight against COVID-19, we intend to demonstrate in this research, that the greater the implementation of technologies in homes, companies or commercial sectors, the greater the opportunities for cybercrime. It is important to highlight that we collected information from recognized websites of public and private entities that are dedicated to data on digital transformation; implementation of technologies; connectivity index; user skills and abilities when navigating cyberspace; on the other hand, they document the most effective and continuous cyber-attacks in recent years, and their main sectors of interest.
Finally, we focus on predicting the degree of truth of the hypothesis, using an experimental methodology from what has already been described and explained; therefore, by means of statistical analysis we clearly present the object of study and techniques visualized in the research process; besides focusing the discussion on the justification objectively in the coincidences of the results and project them to future works focused on the commission of computer crimes; more specifically, computer crime or delinquency, where ICT are the means by which attack vectors are launched.
Lombricompost, uso y saberes para el mejoramiento de suelos en la Granja Agroecológica de la Corporación Universitaria Minuto de Dios
Authors: Sanchez Beltran Juan Fernando , Benito Farfan Neiber Esneider , Peña Carvajal José Luis , Carrillo Barbosa Eny Julieth , Orjuela Hueso Andrés Felipe , Jiménez Abello Arley Fernando 
Published: February 2024

The vermicompost is one is a modern technology, which consists of the intensive rearing of earthworms mainly of the species (Eisenia foetida), for the production of humus, this technique allows to recycle the wastes of vegetable or animal origin to obtain organic matter Nutrients for plants being an activity that generates multiple benefits in agriculture. The microorganisms that make up the organic matter help to improve the texture and structure of the soil by improving its water retention capacity and fertility, making the nutrients necessary for normal growth and development available to the plants.
The arazá (Eugenia stipitata) is a plant that is native to the Amazon which has some problems of demand for its productivity stories such as pH, soil type, etc. The objective of this project was to improve the soil in the agroecological farm of the Uniminuto University Corporation of God, through strategies and alternatives of vermicompost. In addition, a study was carried out on the efficiency of humus for the improvement of plant growth, understanding how favorable it is to use this organic fertilizer if one wants to talk about productivity
On the concept “precedential proper name” and its functional value in the English- language mass media discourse (using the example of English-language publicistic texts published in 2022–2023)
Authors: Волова В.М. , Опарина К.С. , Ракова Е.В. 
Published: February 2024

Цель данной работы выявить среди всего множества имен собственных ряд тех, которые относятся к ядру языковых средств хранения культурной информации и определяют шкалу ценностей англоязычной лингвокультуры, а также раскрыть особенности и ценность функционирования прецедентных имен в публицистических текстах, тесно связанных с их семантической структурой. Материалом исследования послужили электронные версии английских газет в режиме реального времени. Применяя метод лингвостилистического анализа, авторы рассматривают содержание понятия прецедентного имени собственного и функциональный потенциал прецедентных имен собственных: идентификация, коннотация, актуализация, заимствование.
The authors consider the main approaches to the problem of determining precedent proper names as an essential component of human language allowing us to identify and refer to specific individuals, places, or things. In the English language precedent proper names hold a unique place, particularly in the realm of mass media discourse. These names often become synonymous to groundbreaking events, influential figures, or iconic locations, shaping the way information is reported and disseminated. In this paper we delve into the world of precedent proper names and describe the diverse field of their functions in mass media discourse, exploring their impact, challenges, and ethical considerations.
Inspira 4 2020
Authors: Leonardsen Ann-Chatrin Linqvist 
Published: February 2024

Dette er en fulltekst av tidsskriftet Inspira nummer 4, 2020. Merk at tidsskriftet publiseres av Cappelen Damm Akademisk fra og med 15. januar 2021.
Innhold
Sykepleiernes år?: Paula og Therese
Sykepleieres og legers oppfattelse av teamarbeid i intensivavdelinger – en tverrsnittsstudie: Maria Bysheim, Hilde Marit Lygren, Marit Hegg Reime
ASA-klassifisering og kroppsmasseindeks: Ann-Chatrin Leonardsen
Pasienterfaringer med intravenøse langtidskatetre: Ann-Chatrin Leonardsen, Ellen Marie Lunde,Stine Thorvaldsen Smith, Gitte Lise Olsen
Bruk av sjekklister gjennom hele pasientforløpet forbedrer behandlingsresultater: Anette Storesund