bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN PROSES KEPERAWATAN PADA PASIEN GAGAL GINJAL KRONIK DI RUANG KENANGA DI RSUD Dr. H. ABDUL MOELOEK PROVINSI LAMPUNG
Authors: Wijonarko  , Jaya Putra Hendra 
Published: October 2023

Gagal Ginjal Kronik (GGK) adalah kerusakan pada ginjal yang terus menerus dan tidak dapat diperbaiki, yang akan menyebabkan gangguan multisistem. Pada kondisi ini terjadi penurunan fungsi ginjal yang ditandai dengan laju filtrasi glomerulus (LFG) <60 ml/menit/1,73 m2 yang terjadi lebih dari 3 bulan atau penanda kerusakan ginjal yang dapat dilihat melalui albuminuria, deteksi kelainan sedimen urin, kelainan elektrolit, kelainan histologi dan pencitraan yang terdeteksi pada ginjal, serta riwayat transplantasi ginjal. Penelitian ini bertujuan untuk mengetahui Asuhan Keperawatan Pada Pasien Gagal Ginjal Kronik
Penelitian ini menggunakan metode studi kasus dengan partisipan 2 pasien Gagal Ginjal Kronik, data dikumpulkan dengan cara wawancara, observasi, dan pemeriksaan fisik, serta dokumentasi. Penelitian dilaksanakan di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung. Hasil evaluasi terkait pencapaian tujuan keperawatan, yaitu Pada kedua klien telah dilakukan intervensi yang sama dan didapatkan penurunan RR 25x/menit, tampak membran mukosa klien sudah lembab, klien tampak lebih rileks, Klien tampak lebih nyaman.
Peneliti melakukan asuhan keperawatan pada Ny. A. dan Ny. N. Di Ruang Kenangai Di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung, keduanya memiliki diagnosa medis Gagal Ginjal Kronik dengan masalah Ny. A. yaitu Hipervolemia, Bersihan jalan nafas tidak efektif, Pola nafas tidak efektif, Perfusi perifer tidak efektif, dan Intoleransi aktivitas dan pada Ny.N yaitu Hipervolemia, Perfusi perifer tidak efektif, Defisit nutrisi berhubungan, dan Ansietas.

Kata Kunci : Proses Keperawatan, Gagal Ginjal Kronik
Obesity and Risk of Recurrence in Patients With Breast Cancer Treated With Aromatase Inhibitors
Authors: Harborg Sixten , Cronin-Fenton Deirdre , Jensen Maj-Britt Raaby , Ahern Thomas P. , Ewertz Marianne , Borgquist Signe 
Published: October 2023

ImportanceClinical studies confirm that obesity is a risk factor for recurrence in postmenopausal women with hormone receptor–positive (HR+) breast cancer. Evidence suggests that women with obesity do not obtain similar protection from aromatase inhibitors as women with healthy weight.ObjectiveTo examine the associations of body mass index (BMI) with recurrence.Design, Setting, and ParticipantsThe cohort study was conducted using data from the Danish Breast Cancer Group and enrolled postmenopausal women diagnosed with stage I to III HR+ breast cancer from 1998 through 2016. Data analysis was conducted from November 2022 to April 2023.ExposuresBMI was classified as (1) healthy weight (18.5-24.9), (2) overweight (25.0-29.9), (3) obesity (30.0-34.9), and (4) severe obesity (≥35.0) using the World Health Organization guidelines. Healthy weight was considered the reference group in statistical analyses.Main Outcomes and MeasuresFollow-up began 6 months after breast cancer surgery and continued until the first event of recurrence, contralateral breast cancer, new primary malignant neoplasm, death, emigration, end of clinical follow-up at 10 years, or September 25, 2018. Cox regression was used to estimate crude and adjusted hazard ratios with 95% CIs, adjusting for patient, tumor, and treatment characteristics.ResultsA total of 13 230 patients (median [IQR] age at diagnosis, 64.4 [58.6-70.2] years) with information on BMI were enrolled. There were 1587 recurrences with a median (IQR) potential estimated follow-up of 6.2 (3.6-8.5) years. Multivariable analyses revealed increased recurrence hazards associated with obesity (adjusted hazard ratio, 1.18 [95% CI, 1.01-1.37]) and severe obesity (adjusted hazard ratio, 1.32 [95% CI, 1.08-1.62]) vs patients with healthy weight. Patients with overweight had a greater risk, but the results were not statistically significant (adjusted hazard ratio, 1.10 [95% CI, 0.97-1.24]).Conclusions and RelevanceIn this study, obesity was associated with an increased risk of breast cancer recurrence among postmenopausal patients with HR+ early-stage breast cancer treated with aromatase inhibitors. Physicians should be aware of the significance of obesity on breast cancer outcomes to secure optimal treatment benefit in all patients.
Accurate detection of weld seams for laser welding in real‐world manufacturing
Authors: Ali Rabia , Sarmad Muhammad , Tayyub Jawad , Vogel Alexander 
Published: October 2023

AbstractWelding is a fabrication process used to join or fuse two mechanical parts. Modern welding machines have automated lasers that follow a predefined weld seam path between the two parts to create a bond. Previous efforts have used simple computer vision edge detectors to automatically detect the weld seam on an image at the junction of two metals to be welded. However, these systems lack reliability and accuracy resulting in manual human verification of the detected edges. This paper presents a neural network architecture that automatically detects the weld seam edge between two metals with high accuracy. We augment this system with a preclassifier that filters out anomalous workpieces (e.g., incorrect placement). Finally, we justify our design choices by evaluating against several existing deep network pipelines as well as proof through real‐world use. We also describe in detail the process of deploying the system in a real‐world shop floor including evaluation and monitoring. We make public a large well‐labeled laser seam dataset to perform deep learning‐based edge detection in industrial settings.
A Single‐Nucleus Resolution Atlas of Transcriptome and Chromatin Accessibility for Peanut (Arachis Hypogaea L.) Leaves
Authors: Liu Hao , Guo Zenhua , Gangurde Sunil S. , Garg Vanika , Deng Quanqing , Du Puxuan , Lu Qing , Chitikineni Annapurna , Xiao Yuan , Wang Wenyi , Hong Yanbin , Varshney Rajeev K , Chen Xiaoping 
Published: October 2023

AbstractThe peanut is an important worldwide cash‐crop for edible oil and protein. However, the kinetic mechanisms that determine gene expression and chromatin accessibility during leaf development in peanut represented allotetraploid leguminous crops are poorly understood at single‐cell resolution. Here, a single‐nucleus atlas of peanut leaves is developed by simultaneously profiling the transcriptome and chromatin accessibility in the same individual‐cell using fluorescence‐activated sorted single‐nuclei. In total, 5930 cells with 50 890 expressed genes are classified into 18 cell‐clusters, and 5315 chromatin fragments are enriched with 26 083 target genes in the chromatin accessible landscape. The developmental trajectory analysis reveals the involvement of the ethylene‐AP2 module in leaf cell differentiation, and cell‐cycle analysis demonstrated that genome replication featured in distinct cell‐types with circadian rhythms transcription factors (TFs). Furthermore, dual‐omics illustrates that the fatty acid pathway modulates epidermal‐guard cells differentiation and providescritical TFs interaction networks for understanding mesophyll development, and the cytokinin module (LHY/LOG) that regulates vascular growth. Additionally, an AT‐hook protein AhAHL11 is identified that promotes leaf area expansion by modulating the auxin content increase. In summary, the simultaneous profiling of transcription and chromatin accessibility landscapes using snRNA/ATAC‐seq provides novel biological insights into the dynamic processes of peanut leaf cell development at the cellular level.
COF and MOF Hybrids: Advanced Materials for Wastewater Treatment
Authors: Ahmadijokani Farhad , Ghaffarkhah Ahmadreza , Molavi Hossein , Dutta Subhajit , Lu Yi , Wuttke Stefan , Kamkar Milad , Rojas Orlando J. , Arjmand Mohammad 
Published: October 2023

AbstractRecent advances in ordered porous materials, including metal‐organic (MOF) and covalent organic frameworks (COF), are set to revolutionize the strategies used for wastewater treatment. This is attributed to the large surface area, high crystallinity, structural tunability, thermal and chemical stability, and well‐defined structures of MOF and COF. Despite the distinctive properties exhibited by the single system (either MOF or COF), the combination of COF and MOF, as a hybrid construct, offers a remarkable opportunity to achieve superior functionality and performance. The favorable features of COF–MOF hybrids in different wastewater treatment sectors have opened new venues for effective environmental remediation. This review presents the state‐of‐the‐art design, synthesis, and application of COF–MOF hybrids. The synthesis principles, including MOF‐first, COF‐first, and post‐synthetic linkage of pre‐synthesized COFs and MOFs are summarized. The potential of these novel materials is evaluated by considering contaminant sensing, adsorptive removal, and catalytic photodegradation.The conclusion is drawn by assessing the existing hurdles and potential opportunities in the development of COF‐MOF hybrids as an innovative yet viable approach for addressing wastewater treatment.
All Biodisintegratable Hydrogel Biohybrid Neural Interfaces with Synergistic Performances of Microelectrode Array Technologies, Tissue Scaffolding, and Cell Therapy
Authors: Lei Wan‐Lou , Peng Chih‐Wei , Chiu Shao‐Chu , Lu Huai‐En , Wu Chun‐Wei , Cheng Tzu‐Ya , Huang Wei‐Chen 
Published: October 2023

AbstractBiohybrid neural interfaces (BHNIs) are a new class of neuromodulating devices that integrate neural microelectrode arrays (MEAs) and cell transplantation to improve treatment of nerve injuries and disorders. However, current BHNI devices are made from abiotic materials that are usually bio‐passive, non‐biodisintegratable, or rigid, which restricts encapsulated cell activity and host nerve reconstruction and frequently leads to local tissue inflammation. Herein, the first MEA composed of all disintegratable hydrogel tissue scaffold materials with synergistic performances of tissue conformal adhesiveness, MEA technologies, tissue scaffolding and stem cell therapy on a time scale appropriate for nerve tissue repair is proposed. In particular, the MEA conductive tracks are made from extracellular matrix (ECM)‐based double‐cross‐linked dual‐electrically conductive hydrogel (ECH) systems with robust tissue‐mimicking chemical/physical properties, electrical conductivity, and an affinity for neural progenitor stem cells. Meanwhile, the MEA hydrogel substrate prepared from transglutaminase‐incorporated gelatin/silk precursors simultaneously promotes gelation and interfacial adhesion between all MEA stacks, leading to rapid and scalable device integration. When the full hydrogel MEA is subjected to various mechanical stimuli and moisture, it is structurally stable with a low impedance (4 ± 3 kΩ) comparable to a recently reported benchmark. With seamless lamination around peripheral nerve fibers, the device permits successive neural signal monitoring for wound condition evaluation, while demonstrating synergistic effects of spatiotemporally controlled electrical stimulation and cell transplantation to accelerate restoration of motor function. This BHNI is completely degraded by 1 month thus eliminating the need for surgical retrieval to stably remain, interact, and further fuse with host tissues, successfully exhibiting compatible integration of biology and an implanted electrical system.
DNA Hydrogels as Functional Materials and Their Biomedical Applications
Authors: Ma Yinzhou , Duan Xiaocen , Huang Jianyong 
Published: October 2023

AbstractWith the remarkable development of DNA nanotechnology, interest in DNA molecules has expanded beyond its biological role to building blocks in materials science. As a unique branch of DNA‐based materials, DNA hydrogels have exhibited many fascinating characteristics, including broad biocompatibility, precise programmability, convenient modification, and tunable mechanical properties, which make DNA hydrogels ideal biomaterials. Moreover, by combining with functional nucleic acids, such as aptamers, i‐motif nanostructures, CpG oligodeoxynucleotides, and DNAzymes, DNA hydrogels can be further tailored to provide additional target recognition, therapeutic potential, and catalytic activities, allowing them to play important roles in biosensing and medical applications. This review, aims to provide readers with an up‐to‐date overview of the important developments of biomedical DNA hydrogels. First, it introduces different synthetic strategies of hydrogels that utilize DNA as building materials and functional units within the hydrogel networks and discuss their advantages in biomedical applications. Subsequently, new approaches and applications of biomedical DNA hydrogels in the recent years are highlighted, such as therapeutic systems, cell culture platforms, tissue engineering materials, and biosensors. Finally, future perspectives and remaining challenges of DNA hydrogels in biomedicine are presented.
Neurotransmitter‐Mediated Plasticity in 2D Perovskite Memristor for Reinforcement Learning
Authors: Wang Yan , Chen Shidong , Cheng Xiaohan , Chen Wang , Xiong Ziyu , Lv Ziyu , Wu Chunyan , Wang Li , Zhang Guohua , Zhu Xiaobo , Luo Linbao , Han Su‐Ting 
Published: October 2023

AbstractThe neuromorphic computing architecture is a promising artificial intelligence for implementing hierarchical processing, in‐memory computing, event‐driven operation and functional specialization in computing systems. However, current investigations mainly focus on unisensory processing without objective experience which is contrary to the flexible sensory learning capability in the human brain that can sense and process information according to the ever‐changing environment. For example, a dominant paradigm for reconfigurable bio‐learning features is the emotional experience. The neurotransmitter dopamine is released during arousal, influencing the vital brain functions involved in cognition, reward learning, movement and motivation. Here, the on‐demand configuration of a biorealistic synaptic connection based on a 2D CaTa2O7 (CTO) device is demonstrated that can be adaptively reconfigured for a reinforcement learning purpose by the light‐active resistive switching, which originated from the photon‐regulated metaplasticity. The low energy consumption of 12.4 fJ endows the reinforcement learning system with high power efficiency and reliability. Finally, in‐sensor computing with a CTO synapse is implemented with a filtering function to process digital data in a neuromorphic engineering manner. This work demonstrates the feasibility of 2D perovskite neuromorphic device with enhanced biological plausibility in the approaching post‐Moore era.
Polymer‐Initiating Caveolae‐Mediated Endocytosis and GSH‐Responsive MiR‐34a Gene Delivery System for Enhanced Orthotopic Triple Negative Breast Cancer Therapy
Authors: Han Tian‐Yan , Huan Meng‐Lei , Cai Zedong , He Wei , Zhou Si‐Yuan , Zhang Bang‐Le 
Published: October 2023

AbstractGene therapy based on miRNAs has broad application prospects in the treatment of tumors. However, due to degradation and ineffective release during intracellular transport, current gene delivery vectors used for miRNAs limited their actual transfection efficiency. This study develops a novel nonviral vector PEI‐SPDP‐Man (PSM) that can simultaneously target cellular uptake pathways and intracellular responsive release for miR‐34a. PSM is synthesized by connected mannitol (Man) to branched polyethylenimine (PEI) using a disulfide bond. The prepared PSM/miR‐34a gene delivery system can induce and enter to tumor cells through caveolae‐mediated endocytosis to reduce the degradation of miR‐34a in lysosomes. The disulfide bond is sensed at high concentration of glutathione (GSH) in the tumor cells and miR‐34a is released, thereby reducing the expression of Bcl‐2 and CD44 to suppress the proliferation and invasion of tumor cells. In vitro and in vivo experiments show that through the targeted cellular uptake and the efficient release of miR‐34a, an effective antitumor and antimetastasis profiles for the treatment of orthotopic triple negative breast cancer (TNBC) are achieved. This strategy of controlling intracellular transport pathways by targeting cellular uptake pathways in the gene therapy is an approach that could be developed for highly effective cancer therapy.
Lanthanide 3D Supramolecular Framework Boosts Stable Perovskite Solar Cells with High UV Utilization
Authors: Wang Wei , Zhang Jian , Lin Kaifeng , Wang Jiaqi , Zhang Xingrui , Hu Boyuan , Dong Yayu , Xia Debin , Yang Yulin 
Published: October 2023

AbstractIn this work, the ligand‐to‐metal charge transition and Förster resonance energy transfer process is exploited to derive lanthanide–organic framework (Tb‐cpon) modified perovskite solar cells (PSCs) with enhanced performance under UV irradiation. Tb‐cpon‐modified PSCs exhibit rapid response and reduced degradation due to energy downconversion facilitated by effective coupling of UV‐sensitive chromophores to lanthanide luminescent centers, enhancing the spectral response range of the composite films. Furthermore, the characteristic changes of precursor particle sizes suggest formation of Tb‐cpon adducts as intermediate products, leading to enhanced crystallinity and reduced defect concentrations in the Tb‐cpon‐perovskite hybrid film. Accordingly, the Tb‐cpon‐modified PSC devices obtain a champion efficiency up to 23.72% as well as a sensitive photovoltaic conversion even under pure UV irradiation. Moreover, the unencapsulated devices maintain more than 80% of the initial efficiency after continuous irradiation under a 310 nm UV lamp for 24 h (from the Au electrode side), compared to 21% for the control devices.
Simultaneous Enhancement of Efficiency and Operational‐Stability of Mesoscopic Perovskite Solar Cells via Interfacial Toughening
Authors: Yang In Seok , Dai Zhenghong , Ranka Anush , Chen Du , Zhu Kai , Berry Joseph J. , Guo Peijun , Padture Nitin P. 
Published: October 2023

AbstractThe combined effects of compact TiO2 (c‐TiO2) electron‐transport layer (ETL) are investigated without and with mesoscopic TiO2 (m‐TiO2) on top, and without and with an iodine‐terminated silane self‐assembled monolayer (SAM), on the mechanical behavior, opto–electronic properties, photovoltaic (PV) performance, and operational‐stability of solar cells based on metal‐halide perovskites (MHPs). The interfacial toughness increases almost threefold in going from c‐TiO2 without SAM to m‐TiO2 with SAM. This is attributed to the synergistic effect of the m‐TiO2/MHP nanocomposite at the interface and the enhanced adhesion afforded by the iodine‐terminated silane SAM. The combination of m‐TiO2 and SAM also offers a significant beneficial effect on the photocarriers extraction at the ETL/MHP interface, resulting in perovskite solar cells (PSCs) with power‐conversion efficiency (PCE) of over 24% and 20% for 0.1 and 1 cm2 active areas, respectively. These PSCs also have exceptionally long operational‐stability lives: extrapolated T80 (duration at 80% initial PCE retained) is ≈18 000 and 10 000 h for 0.1 and 1 cm2 active areas, respectively. Postmortem characterization and analyses of the operational‐stability‐tested PSCs are performed to elucidate the possible mechanisms responsible for the long operational‐stability.
Preparation and Performance Optimization of Micrometer Scale Ba1.2Ca0.7‐xSiO4:0.1Eu2+, xMn2+ for Application in Mini LED
Authors: Lin Aofan , Seto Takatoshi , Wang Yuhua 
Published: October 2023

AbstractAs the next generation of display technology, Mini Light‐Emitting Diodes (LEDs) have attracted much attention, among which the phosphor used as the backlight should meet the characteristics of small particle size and high brightness. A series of Ba1.2Ca0.7‐xSiO4:0.1Eu2+, xMn2+ are synthesized by the coprecipitation‐solid state method. Hence, the prepared phosphor has a submicron structure with an average particle size of 1.3 ± 0.9 µm. It can be excited by 365–410 nm, with an emission peak of 616 nm and a half‐peak width of 65 nm. At 150 °C, it exhibits a 94% emission intensity and good thermal stability. From 15% to 29%, the external quantum efficiency (EQE) increases. Therefore, the phosphors are suitable for Mini LED displays with near‐ultraviolet light as the excitation source. This method provides a new idea for the development of novel small particle sizes and narrow‐band emission phosphors.
High‐Efficiency All‐Optical Modulator Based on Ultra‐Thin Silicon/Graphene Hybrid Waveguides
Authors: Cao Hongyuan , Ding Mingfei , Chen Haitao , Liu Chaoyue , Yu Laiwen , Zhu Mingyu , Zhao Weike , Guo Jingshu , Li Huan , Yu Zejie , Gao Shiming , Dai Daoxin 
Published: October 2023

AbstractAll‐optical modulation plays a key role in next‐generation optical processing and has attracted enormous attention worldwide. With extraordinary optoelectronic characteristics and friendly integration compatibility with various nanostructures, graphene shows great potential for ultrafast and energy‐efficient all‐optical modulation. Here, high‐efficiency on‐chip all‐optical modulation is experimentally demonstrated based on ultra‐thin silicon/graphene hybrid waveguides, which are complementary‐metal‐oxide‐semiconductor‐compatible and easy to fabricate. Owing to the enhanced light‐graphene interaction enabled by the ultra‐thin silicon photonic platform, the optical nonlinear absorption in graphene is greatly enhanced and a modulation depth of >2 dB is achieved with a saturation threshold of 0.9 pJ per pulse for a 50‐µm‐long modulator. The measured modulation efficiency is as high as 0.052 dB µm−1. Furthermore, the proposed all‐optical modulator has the potential to operate at a bandwidth of hundreds of gigahertz. The present hybrid integration of graphene on ultra‐thin silicon photonic waveguides paves the way toward the applications of on‐chip ultrafast and energy‐efficient all‐optical information processing.
Remarkable Isomer Effect on the Performance of Fully Non‐Fused Non‐Fullerene Acceptors in Near‐Infrared Organic Photodetectors
Authors: Hu Xiantao , Qiao Zhuoran , Nodari Davide , He Qiao , Asatryan Jesika , Rimmele Martina , Chen Zhili , Martín Jaime , Gasparini Nicola , Heeney Martin 
Published: October 2023

AbstractTwo fully non‐fused small‐molecule acceptors BTIC‐1 and BTIC‐2 are reported for application in near‐infrared organic photodetectors (NIR OPDs). Both acceptors contain the same conjugated backbone but differing sidechain regiochemistry, affording significant differences in their optical properties. The head‐to‐head arrangement of BTIC‐2 results in a reduction of optical band gap of 0.17 eV compared to BTIC‐1, which contains a head‐to‐tail arrangement, with absorption spanning the visible and near‐IR regions up to 900 nm. These differences are rationalized on the basis of non‐covalent intramolecular interactions facilitating a more co‐planar conformation for BTIC‐2. OPDs based on PM6:BTIC‐2 deliver a low dark current density of 2.4 × 10−7 A cm−2, leading to a superior specific detectivity of 1.7 × 1011 Jones at 828 nm at ‐2 V. The optimized device exhibits an ultrafast photo response of 2.6 µs and a high ‐3 dB cut‐off frequency of 130 kHz. This work demonstrates that fully non‐fused small‐molecule acceptors offer competitive device performance for NIR OPDs compared to fused‐ring electron acceptors, but with reduced synthetic complexity. Furthermore, the study presents an efficient strategy to enhance device performance by varying conformational locks.