bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Pterocarpinoids from Dolichos marginata ssp. erecta
Authors: Gunzinger Jan , Hostettmann Kurt , Msonthi Jerome D. 
Published: December 2004

AbstractFour new pterocarpinoids, sphenostylin A, B, C, and D (1–4), have been isolated from the CHCl3 extract of the root bark of Dolichos marginata ssp. erecta (Leguminosae) by preparative liquid chromatography. The structures have been established by spectroscopic methods (UV, 1H‐NMR, 13C‐NMR, EI‐MS, DCI‐MS, CD) and chemical transformations. The isolated compounds showed weak antifungal activity against Cladosporium cucumerinum.
Free‐Energy Dependence of the Ion Yield of Photo‐Induced Electron‐Transfer Reactions in Solution
Authors: Vauthey Eric , Suppan Paul , Haselbach Edwin 
Published: December 2004

AbstractA study of photo‐induced electron‐transfer reactions in MeCN with 9,10‐dicyanoanthracene as acceptor and 21 electron donors with transient photoconductivity measurements is reported. The free‐ion yield and the rate constant of back electron transfer are determined. For exergonic reactions, the ‘Marcus‐inverted’ region is observed. The fit with the theory is best, when a nearly solvent‐independent Coulomb term is used in the calculation of the energy balance.
The dimeric and polymeric anhydride of 2,3‐O‐isopropylidene‐β‐D‐ribofuranose. An NMR study
Authors: Winkler Tammo , Ernst Beat 
Published: December 2004

AbstractThe 1H‐ and 13C‐NMR data of the dimeric anhydride 1 of 2,3‐O‐isopropylidene‐β‐D‐ribofuranose are reported together with the 1H‐NOE values. The data show that the products of the polymerization of 1,5‐anhydro‐2,3‐O‐isopropylidene‐β‐D‐ribofuranose are α‐ and β‐D‐ribofuranans and not an α‐D‐ribofuranan and a β‐D‐ribofuranan and a β D ribo‐pyranan as claimed before [2] [3].
Spectroscopic and Electrochemical Behavior of Cyclometalated Pd(II) Complexes
Authors: Maestri Mauro , Sandrini Diana , Balzani Vincenzo , von Zelewsky Alex , Jolliet Philippe 
Published: December 2004

AbstractThe absorption and emission spectra, emission lifetimes, luminescence quantum yields, and electrochemical behavior of the complexes Pd(Phpy)2, Pd(Thpy)2, and Pd(bhq)2 (Phpy−, Thpy−, and bhq−, and bhq− are the deprotonated forms of 2‐phenylpyridine, 2‐(2‐thienyl)pyridine, and benzo[h] quinoline, respectively) have been studied, and the results obtained have been compared with those available for Pt(II) and Pt(IV) complexes containing the same ligands. The intense ligand‐centered absorption bands below 340 nm are strongly perturbed by matalation, and the absorption features in the 340–450‐nm region are likely to include contributions from formally metal‐to‐ligand charge‐transfer transitions. The structured luminescence spectra observed at 77 K (lifetimes are 0.48, 0.28 and 2.6 ms for Pd(Phpy)2, Pd(Thpy)2, and Pd(bhq)2, respectively) have been assigned to transitions having mainly ligand‐centered character, with an increasing metal‐to‐ligand charge‐transfer contribution in going from Pd(bhq)2 to Pd(Phpy)2 and to Pd(Thpy)2. The complexes Pd(phpy)2 and Pd(thpy)2 show two reversible one‐electron reduction waves, whereas reduction of Pd(bhq)2 is irreversible, as is the oxidation of the three complexes.
Herstellung enantiomerenreiner, α‐alkylierter Lysin‐, Ornithin‐ und Tryptophan‐Derivate
Authors: Gander‐Coquoz Marlyse , Seebach Dieter 
Published: December 2004

Synthesis of Enantiomerically Pure, α‐Alkylated Lysine, Ornithine, and Tryptophan DerivativesThe imidazolidinones 9 and 10 as well as the oxazolidinone 18a were prepared in several steps by known methods from lysine and ornithine with an overall yield of ca. 20%. After double deprotonation with LDA, the corresponding dianionic derivatives could be diastereoselectively alkylated with electrophiles (MeI, C6H5CH2Br, C6H5CHO, CH3CHO). Acid hydrolysis led to the two enantiomeric 2‐methyl‐ and 2‐benzyllysines and to the enzyme inhibitor (S)‐2‐methylornithine. Several α‐alkylated tryptophan derivatives were obtained through alkylation of the heterocycles derived from various amino acids with 1‐(tert‐butyloxycarbonyl)‐3‐(bromomethyl)indole (26). Alkaline hydrolysis of the five‐membered auxiliary ring of 30b followed by treatment with HCl afforded (S)‐2‐methyltryptophan (31).
Notiz zur Synthese Eines Optisch Aktiven Ace‐Hemmers mit Amino‐oxo‐benzazepin‐1‐alkansäure‐Struktur mittels enantiokonvergierender kristallisationsinduzierter Racemat‐Trennung
Authors: Boyer Stephen K. , Pfund Rolland A. , Portmann Robert E. , Sedelmeier Gottfried H. , Wetter Hansjürg F. 
Published: December 2004

Note on the Synthesis of an Optically Active ACE Inhibitor with Amino‐oxo‐benzazepine‐1‐alkanoic‐Acid Structure by Means of an Enantioconvergent Crystallization‐Based ResolutionAn enantioselective synthesis of the potent angiotensin‐converting enzyme inhibitor (1′S,3S)‐3‐[(1′‐(ethoxy‐carbonyl)‐3′‐phenylpropyl)amino]‐2,3,4,5‐tetrahydro‐2‐oxo‐1H‐1‐benzazepine‐1‐acetic acid hydrochloride (3) is described which user a crystallization‐based resolution of a racemic amino intermediate with concomitant racemization of the unwanted enantiomer.
Synthese von natürlichen Haloindolen via Hetero‐Cope‐Umlagerung von Vinyl‐N‐phenylhydroxamaten
Authors: Martin Pierre 
Published: December 2004

Synthesis of Natural, Halogenated Indoles via Hetero‐Cope Rearrangement of Vinyl N‐PhenylhydroxamatesAn efficient method for the synthesis of natural 4‐chloro‐6‐methoxyindole (the promutagen from fava beans) and of the two 4,6‐ dibromo‐ and 3,4,6‐tribromoindoles (produced by acorn worms, Enteropneusta) is presented. The key step is a hetero‐Cope rearrangement of the intermediate N‐phenyl‐O‐vinylhydroxylamine derivatives.
Photochemistry of 2,2‐Dimethyl‐2H‐Furo[3,4‐b]Pyran‐4,7(3H, 5H)‐Dione
Authors: Lau Sabine , Margaretha Paul 
Published: December 2004

AbstractIrradiation (λ > 340 nm) of the title compound 2a in t‐BuOH affords 3,3,10,10‐tetramethyl‐2,8‐dioxatricyclo‐[4.3.2.01,6]undecane‐5,9‐dione (3) via photoextrusion of 2‐methylpropene and subsequent photocycloaddition of 2a to the alkene. The same regioisomer 3 is formed selectively and in much higher yields on irradiating 2a in the presence of excess 2‐methylpropene. Irradiation of 3 (λ = 300 nm) in t‐BuOH in the presence of the same alkene gives a 6:1 mixture of spirooxetanes 7a and 7b but not α‐cleavage products. In 2‐propanol, 2a is photoreduced to a 2:1 mixture of diastereoisomeric hydrodimers 9.
Fredericone, neue hochfunktionalisierte Abietanoide aus Blattdrüsen von Coleus fredericii G. TAYL
Authors: Zhu Zhen‐Yan , Nayeshiro Hidekazu , Prewo Roland , Rüedi Peter , Eugster Conrad Hans 
Published: December 2004

Fredericon A, B, C, and D, Novel and Highly Functionalized Abietanoids from Leaf‐Glands of Coleus fredericiiFrom the leaf‐glands of the title plant (fam. Labiatae) two novel, genuie spirocycloopropyl‐coleons have been isolated and structurally characterized. Fredericon A (1) bears the unusal 1,1,2‐tricarbonylcyclopropane substructure that renders the molecule very suseptible to nucleophile‐promoted rearrangements. Biogenetically intriguing is the presence of a 3‐acetoxypropyl side‐chain in fredericon B (3). Its formation from the well known isopropyl group is explained by transformation of the latter into a spirocyclopropane, followed by a reductive opening of the cyclopropane and reducation of the aldehyde, MeOH addition to 1, yields fredericon C (5), a derivative of 1H‐phenanthro[3,2‐b]pyran‐7,12(2H,8H)‐dione by two consecutive introlecular nucleophilic openings of the cyclopropane ring and the derived methoxy‐oxirane. Similar methanolysis of a crude fraction of 1, produced, in addition to 5, the fredericon D, a novel derivative of 3H‐phenanthro[3,2‐b]pyran‐2‐(4H)‐one(6).
Mécanisme de solvolyse des cis ‐ et trans‐(p‐toluénesulfonates) d'aryl1‐2‐cyclopentyle II. Etude des étapes ultérieures à l'ionisation lors de la solvolyse des cis‐(p‐toluénesulfonates) d'aryl‐2‐cyclopentyle
Authors: Ronco G. , Guyon R. , Villa P. 
Published: December 2004

Solvolysis Mechanism of cis‐ and trans‐2‐Arylylopentylp‐ Toluenesulfonates, Subsequent Step in cis‐2‐Arylcyclopentyl p‐Toluenesulfonate SolvolysisThe solvolysis of a series of 1‐deuteriated, 2‐deuteriated, and undeuteriated cis‐2‐arylcyclopentyl p‐toluenesulfonates in HCOOH, AcOH, and EtOH has been studied. We have shown that classical secondary carbocation arising from substrate ionisation undergoes two concurrent processes, namely kc (direct products formation) and kip (hydrogenium bridged ion formation as tertiary carbocation or products precursor). The intrinsic properties of solvent and the aryl substitutant electronic effects the total solvolysis rate and the respective contributions of k c and k ip processes. Comparing the observed and calculated kinetic isotope of D–C(2) allows one to conclude that no step can called ‘rate‐determining step’ but that the steps following ionisation have a preponderent effect on the total solovolysis rate.
Anion‐receptor molecules: Synthesis of a chiral and functionalized binding subunit, a bicyclic guanidinium group derived from L‐ or D‐ asparagine
Authors: Echavarren Antonio , Galán Amalia , de Mendoza Javier , Salmerón Armando , Lehn Jean‐Marie 
Published: December 2004

AbstractThe optically active (4S,8S)‐4, 8‐bis(hydroxymethyl)‐1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene ((S,S)‐1) has been synthesized in nine steps from L‐asparagine with a total yield of 5.1%. Similarly, the enantiomer (R,R)‐1 has been prepared from D‐asparagine. (S,S)‐ and (S,S)‐1 are representative examples of rigid and functionalized bicyclic guanidine systems and constitute useful intermediates in the construction of chiral selective anion‐receptor molecules.
Photooxygenation of 5‐aryl‐2,4‐diaminopyrimidines leading to 4‐amino‐1,3,5‐triazin‐2‐yl ketones and, in the presence of sodium borohydride, to 5,6‐dihyro‐4(3H)‐pyrimidinones
Authors: Oppenländer Thomas , Pfoertner Karl‐Heniz , Schönholzer Peter 
Published: December 2004

AbstractThe photosensitized oxygenation of 5‐aryl‐2,4‐diaminopyrimidines 1 in protic solvent led to the formation of the new 4‐amino‐1,3‐5‐triazin‐2‐yl ketones 2 in high yields. The structures of 2 were elucidated by spectroscopical means, especially by 13C‐NMR and UV data. Photooxygenation of 2,4‐diamino‐5‐(p‐chlorophenyl)‐6‐ethylpyrimidine 1a under reductive conditions, e.g. In the presence of excess NaBH4, gave 2‐amino‐5‐(p‐chlorophenyl)‐t‐6‐ethyl‐5,6‐dihydro‐r‐5‐hydroxy‐4(3H)‐pyrimidinone (4a), the structure of which was determined by X‐ray analysis. In the proposed mechanisms for both types of reactions, the dipolar ion 5 is assumed to be a common intermediate. For the new efficient synthesis of 1,3,5‐triazines from 2,4‐diaminopyrimidines, a 5‐aryl substituent seems to be essential.
Studies on Antifungal Agents. Part 22. 3‐aryl‐5‐[(aryloxy)alkyl]‐3‐[(1H‐imidazol‐1‐yl)methyl]‐2‐methylisoxazolidines and related derivatives
Authors: Mullen George B. , Swift Patricia A. , Marinyak David M. , Allen Stanley D. , Mitchell Jeffrey T. , Kinsolving C. Richard , Georgiev Vassil St. 
Published: December 2004

AbstractThe synthesis and antifungal activity of a novel series of 3‐aryl‐5‐[(aryloxy)alkyl]‐3‐[(1H‐imidazol‐1‐yl)‐methyl]‐2‐methylisoxazolidines and related compounds, are discussed. The synthesis of the title compounds was accomplished via a 1,3‐dipolar cycloaddition of α‐substituted ketonitrones with l‐alkenyl phenyl ethers (Scheme 2 and 3). The compounds were evaluated for in vitro antifungal activity in solid agar cultures against a broad variety of yeast and systemic mycoses and dermatophytes. While antifungal activity was evident throughout the series, in general, derivatives having halogen atom(s) in either or both aryl rings demonstrated the highest potency, especially against Trichophyton rubrum and Candida albicans. The dichloro analog 20 (PR 967‐248) was found to possess the most useful activity. Its minimum inhibitory concentration (MIC) values ranged between 0.2 and 2.0 μg/ml, as compared to 0.2–20.0 μg/ml for the standard drug ketoconazole (4).
Captodative olefins in normal and inverseDiels‐AlderReactions
Authors: Mertes Jürgen , Mattay Jochen 
Published: December 2004

AbstractOlefins with captodative substitution are reactive dienophiles inDiels‐Alderreactions with normal and inverse electron demand. This is shown for reactions of 2‐(tert‐butylthio)acrylonitrile (1) with various dienes and heterodienes,e.g.1,3‐cyclohexadiene, hexachloro‐1, 3‐cyclopentadiene, acrolein, methacrolein, and methyl vinyl ketone (Schemes 2and3). In case of the hetrodienes, 3,4‐dihydro‐2H‐pyrans are formed beside small amounts of tetrahydrothiophenes; however, with methyl vinyl ketone, both reaction pathways are equally followed. The high reactivity of captodative olefins inDiels‐Alderreactions are rationalized on the basis ofSustmann's FMO model under consideration of Viehe's concept of captodative substitution of alkenes.
Anion‐receptor molecules: Macrocyclic and macrobicyclic effects on anion binding by polyammonium receptor molecules
Authors: Hosseini Mir Wais , Lehn Jean‐Marie 
Published: December 2004

AbstractThe stability constants for anion binding by the acyclic hexaamine 1, its macrocyclic analogue 2, and the bicyclic compound 3 in their protonated forms are reported. Compound 3 forms stable and selective complexes with halide ions, the stability sequence being I− > Br− > Cl−. Compound 2 forms more stable complexes with sulfate, oxalate, and malonate dianions than its acyclic analogue 1 and shows a better selectivity pattern. Compound 3 forms stronger complexes with oxalate2− than 2 and shows a remarkably high binding selectivity between oxalate2− and malonate2−. The comparison of the ability of 1–3 to complex anions demonstrates the macrocyclic and macrobicyclic effects on anion binding stability and selectivity.
Synthèses et caractérisation d'une nouvelle classe de sels de flavylium; voie d'accès aux composés du type (acétoxy‐2‐phényl)2‐méthylidène‐4‐4H‐benzopyranne‐1. Structure radiocristallographique de l'(acétoxy‐2‐méthyl‐5‐phényl)‐2‐diméthyl‐4, 6‐benzopyranne‐1‐ylium pentachlorostannate: mise en évidence de ponts chlore dans l'uniteé decachlorodistannate(2–)
Authors: Jolibois Henri , Vebrel Joél , Guyetant René , Theobald François 
Published: December 2004

Synthesis and Characterization of a New Class of Flavylium Salts; a Facile Route to the 2‐(2‐Acetoxyphenyl)‐4‐methylidene‐4H‐1‐benzopyran Derivatives. X‐Ray Crystal Structure of 2‐(2‐Acetoxy‐5‐methylphenyl)‐4,6‐dimethyl‐1‐benzopyranylium Pentachlorostannate: Supporting evidence of Chlorine Bridging in the Decachlorodistannate(2–) UnitSeveral mixtures of compounds 1 and 2 were synthesized from SnCl4 and p‐substituted aryl acetates. Separation of 1/2 was achieved either by treatment of the mixture with MeCN providing the pure complex 1 or by reaction with MeCOCl leading selectively to a new class of flavylium salts 3 or 4. The structure of 2‐(2‐acetoxy‐5‐methylphenyl)‐4,6‐dimethyl‐l‐benzopyranylium pentachlorostannate (3a) was determined by single‐crystal X‐ray diffraction. The Sn‐atoms are hexacoordinated in the dimeric unit Sn2Cl through Cl bridging. Furthermore, we report the easy preparation of 1‐benzopyran derivatives starting from the salts 3.
A Total Synthesis of (±)‐ Aphidicolin: Regio‐ and stereoselective conversion of 3α,18‐Di‐O‐benzyl‐17‐nor‐14‐aphidicolen‐16‐one into (±)‐aphidicolin
Authors: Lupi Alessandro , Patamia Maria , Bettole Rinaldo Marini 
Published: December 2004

AbstractA regio‐ and steroselective conversion of the totally synthetic 3α, 18‐di‐O‐benzyl‐17‐nor‐14‐aphidicolen‐16‐one (5), into (±)‐aphidicolin 1, by hydroxylation of the 2‐methylidenebicyclo[3.2.1] oct‐3‐ene derivative 6 is described. Compound 5 was a key intermediate in our previously described total synthesis of 2, which represented a formal synthesis of 1.
The Radical Cation of Cyclobutene and its Photoproduct. Preliminary communication
Authors: Gerson Fabian , Qin Xue‐Zhi , Bally Thomas , Aebischer Jean‐Nicolas 
Published: December 2004

AbstractThe hitherto unknown radical cation of cyclobutene (2) has been generated in a CFCl3 matrix by γ rays at 77 K. The coupling constants, as determined from the ESR spectrum of 2+, are 2.80 and 1.11 mT for the four CH2 and the two CH = protons, respectively. Photo‐induced ring opening of 2+ yields a radical cation which exhibits the same ESR and ENDOR spectra as those observed upon direct ionization of s‐trans‐buta‐1, 3‐diene (s‐trans‐1). The radical cation s‐trans‐1+, should, therefore, be the final product of this conversion.
Asymmetric Catalysis by Vitamin B12. The isomerization of achiral epoxides to optically active allylic alcohols
Authors: Su Heng , Walder Lorenz , Zhang Zhong‐da , Scheffold Rolf 
Published: December 2004

AbstractAchiral epoxides are isomerized to optically active allylic alcohols under the influence of catalytical amounts of cob(I) alamin in protic polar solvents.
Dreifach‐Diamantstruktur von. 2,6‐Dioxoadamantan‐1,3,5,7‐tetracarbonsäure (Hydrat) als Wirtsgitter für Essigsäure
Authors: Ermer Otto , Lindenberg Lorenz 
Published: December 2004

Triple‐Diamond Structure of 2,6‐Dioxoadamantane‐1,3,5,7‐tetracarboxylic Acid (Hydrate) as Host Lattice for Acetic AcidA novel solid‐state channel‐inclusion compound characterized by X‐ray methods is based on three interpenetrating, translationally equivalent super‐diamond network as host structure and AcOH as guest. The diamondoid host network are fromed by the 2,6‐dioxoadamantane‐1,3,5,7‐tetracarboxylic acid tied together via pairwise H‐bonds. The channels embedding the AcOH molecules may be viewed as symmetric triple helices winding about the guest species. Prospects regarding design and potentialities of diamondoid inclusion compounds are exemplified and appear promising.
Ruthenium(II) Complexes with Three Different Diimine Ligands
Authors: von Zelewsky Alex , Gremaud Gabriel 
Published: December 2004

AbstractThe synthesis of tri‐heteroleptic complex of Ru(II) with diimine ligands is describe. Ten compounds [Ru(R2bpy) (biq) (L)][PF6]2(R = H, CH3); L = 2,2′‐bipyridine (bpy), 4,4′‐dimethyl‐2,2′‐bipyridine (Me2bpy), 2,2′‐bipyrimidine (bpm), 2,2′‐biisoquinoline (biiq), 1,10‐phenanthroline (phen), dipyrido[3,2‐c:2′,3′‐e]pyridazine (taphen), 2,2′‐biquinoline (biq), 6,7‐dihydrodipyrido[2,3‐b:3,2‐j][1,10]‐phenanthroline (dinapy), 2‐(2[pyridyl)quinoline (pq), 1‐(2‐pyrimidyl)pyrazole] (pzpm), 2,2′‐biimidazole (H2biim) are characterized by elemental analysis, electronic and1H‐NMR spectroscopy. The relative photosustitution rates of biq in MeCN are given at three temperatures.
Synthesis of Optically Pure Tricarbonyliron Complexes of 5,6‐Dimethylidenebicyclo[2.2.2.]oct‐2‐yl derivatives. Crystal structure and absolute configuration of (+)‐tricarbonyl(1S,2S,4R,5R,6S)‐C,5,6,C,‐η‐(5,6‐dimethylidenebicyclo[2.2.2]oct‐2‐yl p‐bromobenzoate)iron
Authors: Carrupt Pierre‐Alain , Berchier Fabienne , Vogel Pierre , Pinkerton Alan A. , Schwarzenbach Dieter 
Published: December 2004

AbstractThe title complexes have been derived from tricarbonyl [(1R,4S,5S,6R,)‐C,5,6,C‐η‐(5,6‐dimethylidenebicyclo[2.2.2]oct‐2‐ene)]iron (1.). The crystal structure and absoulte configuration of (+)‐tricarbonyl (1S,2S,4R,5R,6S)‐C,5,6,C,‐η‐(5,6‐dimethylidenebicyclo[2.2.2]oct‐2‐yl p,‐bromobenzoate)]iron ((+)−6) determined by X‐ray diffrac‐tion studies proved earlier attribution of the relative configuration (endo us. exo,) of the tricarbonyliron moieties in complexes 1 and 2 of 5,6‐dimethylidenebicyclo[oct‐2‐ene. The structure of (+)‐6 confirms the absolute configuration derived earlier from circular‐dichroism spectra of 5,6‐dimethylidenebicyclo[2.2.2]oct‐2‐yl esters and 5,6‐dimethylidenebicyclo[2.2.2]octan‐2‐one.
Synthesis and Steroidogenic Activity of Covalently Dimerized Corticotropin (ACTH) Fragments
Authors: Stolz Monica B. , Fauchère Jean‐Luc 
Published: December 2004

AbstractThe chemical synthesis by classical methods in solution of a dimer of the sequence 1 to 24 of adrenocorticotropin(ACTH) is described. The two monomers were covalently linked through their C‐termini, using lysine amide as spacer. Dimerization did not improve significantly the potency of the agonist ACTH‐(1–24), while it strongly potentiated the antagonistic effect of the fragments ACTH‐(11–24) and ACTH‐(7–24) in the stimulation of steroidogenesis in isolated adrenal cells. The results seem to imply a microaggregation of the receptors at the adrenal cell surface.
Stoffwechselprodukte von Mikroorganismen. 250. Mitteilung. Maduraferrin, ein neuartiger Siderophor aus Actinomadura madurae
Authors: Keller‐Schierlein Walter , Hagmann Leonhard , Zähner Hans , Huhn Wolfgang 
Published: December 2004

Maduraferrin, a Novel Siderophore from Actinomadura maduraeFrom a strain of Actinomadura madurae, a new siderophore was isolated. Maduraferrin is the Fe complex of an oligopeptide composed of salicylic acid, β‐alanine, glycine, L‐serine, Nδ‐hydroxy‐Nα‐methyl‐L‐ornithine, and L‐hexahydropyridazine‐3‐carboxylic acid. The complexing centers are a salicylamide moiety, a hydroxamic‐acid group and an acid hydrazide group.
Synthesis and Characterization of Crown‐Ether‐Containing Phthalocyanines with Group‐IV‐A Elements
Authors: Ahsen Vefa , Yilmazer Emel , Gürek Ayşegül , Gül Ahmet , Bekâroǧlu Özer 
Published: December 2004

AbstractGroup‐IV‐A phthalocyanines with four crown ether substituents have been prepared from 4′,5′‐dicyanobenzo(15‐crown‐5), 4′,5′‐diiminoisoindolino(15‐crown‐5), or metal‐free phthalocyanine and the corresponding metal salts. The axial ligands of dichloro[tetra(15‐crown‐5)phthalocyaninato]silicon or ‐tin have been converted into dihydroxy derivatives by hydrolysis in aqueous Et3N. The catalytic effect of H2O‐free CaC12 in quinoline is used for the polycondensation of dihydroxysilicon‐phthalocyanine to cofacially arrayed polymers. The thermal stability of group‐IV‐A‐metal phthalocyanines is confirmed by the higher initial decomposition points (290–440°) compared to those of the corresponding transition‐metal phthalocyanines.
Diazotisations in Highly Concentrated Mineral Acids: The nitrosation mechanism of anilinium and hydroxylammonium ions through proton loss from the ammonio group
Authors: Zollinger Heinrich 
Published: December 2004

AbstractIt is shown that the acidity dependence of the rate of nitrosation of aromatic amines and of hydroxylamine in strongly acidic aqueous solutions does not necessarily involve the rearrangement of a charge transfer complex (consisting of the NO+ ion and the substrate with an NH group) in concert with a proton loss at the NH group. More likely, proton loss of the charge complex preceeds the π → N rearrangement of the NO+ ion.
Design and Synthesis of a Potential Dopamine D‐1 Antagonist
Authors: Revesz Laszlo , Meigel Harald 
Published: December 2004

AbstractThe diastereoselective synthesis of (±)‐trans‐transoid‐7‐bromo‐8‐hydroxy‐1‐methyl‐1,2,3,4,4a,5,10,10a‐octahydro‐10‐phenylbenzo[g]quinoline (8) is described, using an intramolecular Diels‐Alder reaction and a reductive cyclisation for piperidine ring‐formation as key steps. Compound 8 was prepared as a putative D‐1 receptor antagonist which contains (2,2‐diphenylethyl)amine as a partial structure.
Synthesis of New 1,2,4‐Trioxanes and their Antimalarial Activity
Authors: Jefford Charles W. , McGoran Ernest C. , Boukouvalas John , Richardson Geoffrey , Robinson Brian L. , Peters Wallace 
Published: December 2004

AbstractThe three dihydronaphtho[1,2,4]trioxines 9–11 have been synthesized and two of them converted to the five carbamate and ester derivatives 12–16 (Schemes 1 and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensitive N strain of Plasmodium berghei in mice. On comparison with artemisinin (1) and dihydroartemisinin (2), modest activity was found. The four most active compounds were some 12–18 times less potent than 1.