bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fixed‐time adaptive neural tracking control for nonlinear multiagent systems with communication link faults
Authors: He Cheng , Qi Ruiyun , Jiang Bin 
Published: October 2023

AbstractThis paper addresses the fixed‐time adaptive neural distributed control problem of uncertain nonlinear multiagent systems (MASs) with unknown communication link faults. To handle the unknown terms caused by communication link faults and the unknown functions in each agent, a radial basis function neural network (RBF NN) is employed. In contrast to existing methods that focus solely on practical finite‐/ fixed‐time stability of nonlinear systems, the control scheme developed in this paper goes beyond by not only mitigating the effects of unknown communication link faults in nonlinear MASs but also addressing the singularity problem of fixed‐time controllers. These advancements are realized through the design of new power exponent functions and the introduction of new lemmas. This way, the tracking error of MASs converges to a preset range within a fixed time and achieves better control performance. Finally, the feasibility of the proposed scheme is verified through two simulations.
Unveiling the Hidden Struggles: Exploring the Profound Impact of Advanced Stage Cutaneous T-Cell Lymphoma on Quality of Life
Authors: Ottevanger Rosanne , Feenstra Judith S. , van Vliet Liesbeth M. , van Beugen Sylvia , Evers Andrea W. M. , Kennedy Cees , Willemze Rein , Vermeer Maarten H. , Quint Koen D. 
Published: October 2023

Abstract
Erythrodermic mycosis fungoides and Sézary syndrome are chronic, relapsing-remitting diseases that greatly impacts patients' quality of life (QoL). Mogamulizumab-kpkc (Mogamulizumab) is a novel therapeutic agent for cutaneous T-cell lymphomas with a notable impact on progression-free survival. Qualitative assessment methods allow a broader exploration and greater insight in individual patient experience than quantitative studies. However, there is limited data on the impact of mogamulizumab on health-related QoL. To investigate the impact of erythrodermic cutaneous T-cell lymphoma (E-CTCL) on QoL and the effect of mogamulizumab on the QoL. Semi-structured interview were conducted with seven patients with E-CTCL that were receiving mogamulizumab treatment. Five major themes arose: Diagnosis and the diagnostic delay and uncertainty experienced by participants; Physical functioning due to the high symptom burden; Psychological and social functioning considering the significant impact on daily life; Treatment and the effect of mogamulizumab; and Support by family, friends and health professionals. Mogamulizumab therapy resulted in a significant decrease of symptoms. The small sample size should also be taken into account although data saturation was reached. This study gives a broad insight into the large impact of E-CTCL and the major consequences on the physical functioning as well as on the emotional/psychological and social well-being. Mogamulizumab appears to have a positive effect on symptoms.
Protein Corona Sensor Array Nanosystem for Detection of Coronary Artery Disease
Authors: Lee Gha Young , Li Andrew A. , Moon Intae , Katritsis Demos , Pantos Yoannis , Stingo Francesco , Fabbrico Davide , Molinaro Roberto , Taraballi Francesca , Tao Wei , Corbo Claudia 
Published: October 2023

AbstractCoronary artery disease (CAD) is the most common type of heart disease and represents the leading cause of death in both men and women worldwide. Early detection of CAD is crucial for decreasing mortality, prolonging survival, and improving patient quality of life. Herein, a non‐invasive is described, nanoparticle‐based diagnostic technology which takes advantages of proteomic changes in the nano‐bio interface for CAD detection. Nanoparticles (NPs) exposed to biological fluids adsorb on their surface a layer of proteins, the “protein corona” (PC). Pathological changes that alter the plasma proteome can directly result in changes in the PC. By forming disease‐specific PCs on six NPs with varying physicochemical properties, a PC‐based sensor array is developed for detection of CAD using specific PC pattern recognition. While the PC of a single NP may not provide the required specificity, it is reasoned that multivariate PCs across NPs with different surface chemistries, can provide the desirable information to selectively discriminate the condition under investigation. The results suggest that such an approach can detect CAD with an accuracy of 92.84%, a sensitivity of 87.5%, and a specificity of 82.5%. These new findings demonstrate the potential of PC‐based sensor array detection systems for clinical use.
Multi‐Omics Reveals the Genetic and Metabolomic Architecture of Chirality Directed Stem Cell Lineage Diversification
Authors: Zheng Huimin , Jiang Shengjie , Li Meijun , Liu Jinying , Wang Xiaowei , Liu Minghua , Feng Chuanliang , Wei Yan , Deng Xuliang 
Published: October 2023

AbstractChirality‐directed stem‐cell‐fate determination involves coordinated transcriptional and metabolomics programming that is only partially understood. Here, using high‐throughput transcriptional‐metabolic profiling and pipeline network analysis, the molecular architecture of chirality‐guided mesenchymal stem cell lineage diversification is revealed. A total of 4769 genes and 250 metabolites are identified that are significantly biased by the biomimetic chiral extracellular microenvironment (ECM). Chirality‐dependent energetic metabolism analysis has revealed that glycolysis is preferred during left‐handed ECM‐facilitated osteogenic differentiation, whereas oxidative phosphorylation is favored during right‐handed ECM‐promoted adipogenic differentiation. Stereo‐specificity in the global metabolite landscape is also demonstrated, in which amino acids are enriched in left‐handed ECM, while ether lipids and nucleotides are enriched in right‐handed ECM. Furthermore, chirality‐ordered transcriptomic‐metabolic regulatory networks are established, which address the role of positive feedback loops between key genes and central metabolites in driving lineage diversification. The highly integrated genotype‐phenotype picture of stereochemical selectivity would provide the fundamental principle of regenerative material design.
Undiagnosed cardiomyopathy: An incidental finding in a recreational soccer player—A case report and literature review
Authors: Allwood Richard P. 
Published: October 2023

AbstractIntroductionArrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disease characterised by progressive fibrofatty tissue replacement of the myocardium. Several arrhythmogenic cardiomyopathy (ACM) phenotypes are now recognised, including right‐dominant, biventricular, and left‐dominant variants, which led to the development of the 2020 International criteria (Padua criteria).Raising awareness of these variants is crucial as their clinical entity can be concealed. This is particularly important in the athletic population. Exercise can promote the development of the phenotype and accelerate disease progression, resulting in left ventricular (LV) involvement and systolic dysfunction, which can cause ventricular arrhythmias and sudden death.Case DescriptionA late adolescent male was escorted by paramedics to an emergency department following a medium‐speed motor vehicle accident. A multimodality approach was implemented involving a 12‐lead electrocardiogram (ECG), transthoracic echocardiography (ECHO) and cardiac magnetic resonance (CMR) imaging. An unknown cardiomyopathy was revealed with diagnostic clues suggesting biventricular ACM in a recreational soccer player, when using the Padua criteria.ConclusionACM should be considered in the evaluation of an unexplained cardiomyopathy presenting with possible syncopal events. This case describes the clinical features of an ACM patient, emphasising the utility of ECG, ECHO and CMR in determining biventricular involvement.CMR is a powerful tool for the diagnosis of ACM and the identification of myocardial fibrosis with late gadolinium enhancement (LGE). The use of 12‐lead ECG and 2‐dimensional (2D) strain imaging may also raise suspicion of biventricular phenotypes and predict LV involvement with significant myocardial fibrosis.
Recyclization of 5‐Amino‐ oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Authors: Shablykin Oleh V. , Brovarets Volodymyr S. , Shablykina Olga V. 
Published: October 2023

AbstractThe recyclizations of 5‐amino‐ and 5‐hydrazine‐1,3‐oxazoles mainly with electron‐withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α‐aminoazoles. 5‐Amino/hydrazine‐1,3‐oxazoles undergo recyclization both in nucleophilic (amines, hydrazine, thionating agents) and electrophilic medium ((trifluoro)acetic acid, other acylating agents). The numerous types of functionalized heterocycles can be easily obtained with the usage of these recyclizations, such as the derivatives of 3‐amino‐6,7‐dihydro‐5H‐pyrrolo[1,2–a]imidazole, imidazolidine‐2,4‐dione, 1H‐pyrazole‐3,4,5‐triamine, 5,6‐diamino‐2,3‐diphenylpyrimidin‐4(3H)‐one, 2‐(2‐R‐7‐oxo‐5‐(trifluoromethyl)oxazolo[5,4–d]pyrimidin‐6(7H)‐yl)acetic acid, 2‐R‐4‐(5‐R′‐1,3,4‐oxadiazol‐2‐yl)oxazol‐5‐amine, (amino(5‐amino‐1,3,4‐thiadiazol‐2‐yl)methyl)phosphonate.
Prevalence and molecular identification of gastrointestinal nematodes in Qinghai‐Tibetan Plateau of China
Authors: Ai Sitong , Zhang Zhichao , Wang Jinghan , Wang Xiaoqi , Liu Cheng , Duan Ziyuan 
Published: October 2023

AbstractBackgroundGastrointestinal nematodes (GINs) have seriously affected the production and earnings of animal husbandry in various countries, while some species of GINs infect humans. At present, little is known about the species and prevalence of GINs in Qinghai‐Tibetan Plateau (QTP).MethodsIn this study, 528 fresh faecal samples were collected from typical areas in different altitudes with seven species of livestock in Qinghai, Tibet, Gansu and Yunnan Provinces. ITS‐2 rRNA gene of nematodes was employed to detect by PCR and sequencing analysis. Phylogenetic analysis of related sequences was performed using MEGA 6.0 software.ResultsThe overall prevalence of GINs was 80.3% with 20 species of GINs detected, while Teladorsagia circumcincta was the dominant one, and four of which were zoonotic species such as Trichostrongylus colubriformis, Trichostrongylus axei, Trichostrongylus vitrinus and Oesophagostomum stephanostomum.ConclusionThe study provided panoptic information on the prevalence and species diversity of GINs in QTP area, which is useful and valuable for reference of measure formulation in livestock husbandry and public health concerns. The parasites of T. circumcincta, Cylicocyclus nassatus, Strongylus edentatus, Cylicostephanus longibursatus, Telephlebia brevicauda, Cyathostomum catinatum, Mecistocirrus digitatus, Cooperia punctata, Cylicodontophorus bicoronatus, Nematodirus oiratianus and Oesophagostomum asperum were firstly reported the presence in QTP area. The study also showed that horse could be infected by T. circumcincta, goat could be infected by C. nassatus, cattle could be infected by S. edentatus and C. bicoronatus,and O. stephanostomum could infect yak, cattle and Mongolian sheep in worldwide. Nevertheless, more investigations are needed, such as microscopic examination, to accurately determine the species in the region.
Made-to-Measure: In and Out of Touch with the Old-Growth Forest
Authors: Vola Joonas , Rautio Pasi , Rantala Outi 
Published: October 2023

AbstractThe condition of forests is a major issue when it comes to climate change and biodiversity. One way to define the quality of a forest is by its age. In the cross pressure of socio-economic and ecological guidelines, what qualifies as an old-growth forest is not determined by a mere number but the co-constitution of various measurements, indicators, political ambitions, and the performance of the measured biological ‘units’ themselves. This transdisciplinary chapter studies how old-growth forests are made-to-measure, moving from close proximity encounters with an indicator organism, being-with-beard lichen, to the internationally defined level and timescale of economic activity and (un)management in categorising forest ecology, wherein various compromises in decision-making may also compromise local ecosystems and the vastness of scale in the biosphere. The study heads off to the ‘roots’ of science—definitions, conceptualisations, onto-epistemology, and methodologies—considering how they as active processes are performing the entity of the ‘old-growth forest’ by cutting-together-apart on multiple scales.
Slowing Down with Stinging Nettle
Authors: Kinnunen Veera , Martz Françoise , Rantala Outi 
Published: October 2023

AbstractIn ‘Slowing down with stinging nettle,’ Veera Kinnunen, Françoise Martz, and Outi Rantala seek to develop transdisciplinary knowing methods by gathering around stinging nettle. Due to the rich cultural and biological heritage inscribed in nettle, it provides a fruitful starting point for transdisciplinary theorising about human–plant relations from the local nettle that is simultaneously present around the world. The three authors—a sociologist, a tourism researcher, and a biologist—end up inviting two plant mentors to their conversations, enabling them to attend to situated nettle relations. The plant mentors’ rich situated expertise in utilising nettle enables the authors to pay attention to the material, symbolic, and temporal particularities embedded in making a living with nettle.
Auswirkungen der neuen Mindestmengen in der Viszeralchirurgie auf die Gesundheitsversorgung in Brandenburg aus der Perspektive der Versorger:innen
Authors: Kugler C. M. , Gretschel S. , Scharfe J. , Pfisterer-Heise S. , Mantke R. , Pieper D. 
Published: October 2023

Zusammenfassung
Hintergrund
In der Viszeralchirurgie wurden die Mindestmengen (Mm) für komplexe Eingriffe am Ösophagus und Pankreas 2023 bzw. 2025 angehoben. Kliniken, die die Mm nicht erreichen, dürfen diese Eingriffe nicht mehr durchführen und haben keinen Vergütungsanspruch.

Ziel der Arbeit
Die Studie beantwortet die Fragen, welche Auswirkungen die an der Versorgung im Land Brandenburg Beteiligten durch die neuen Mm erwarten und welche Lösungsansätze sie für das dünn besiedelte Flächenland sehen.

Material und Methoden
Es wurden 19 Expert:inneninterviews mit Krankenhausangestellten (Chefärzt:innen, Oberärzt:innen, Pflegedirektor:innen), niedergelassenen Ärzt:innen und Patient:innenvertretungen im Zeitraum 07/2022 bis 01/2023 durchgeführt. Die Datenauswertung erfolgte inhaltsanalytisch.

Ergebnisse
Die Interviewten erwarteten für die operative Versorgung eine Umverteilung in wenige Kliniken (Zentren); hingegen würden mehr Kliniken, die die komplexen Operationen nicht (mehr) durchführen dürfen, die Funktion von „Portalkliniken“ für die Basisversorgung, Diagnostik und Nachsorge übernehmen. Die Umverteilung könnte auch Auswirkungen auf nicht direkt von der Mm-Regelung betroffene Behandlungen haben. Die Erhöhung der Mm habe außerdem Auswirkungen auf die Weiterbildung und Personalgewinnung. Als Lösungsvorschlag wurden insbesondere Kooperationen zwischen verschiedenen Kliniken diskutiert, die strukturell zunächst gefördert werden müssten.

Diskussion
Mm beeinflussen nicht nur Ergebnisqualität und Erreichbarkeit, sondern ziehen eine Vielzahl weiterer Effekte nach sich. Insbesondere für dünn besiedelte Regionen stellen Mm Herausforderungen für den Zugang zu Ösophagus- und Pankreasoperationen sowie die Kommunikation zwischen Zentren und Portalkliniken bzw. ambulanten Versorger:innen dar.
Observations from Australia's National Surgical Mortality Audit
Authors: Hansen Dylan , Itotoh Franca , Helena Kopunic , Aitken R. James ,   the Australian and New Zealand Audit of Surgical Mortality
Published: October 2023

AbstractBackgroundAustralia is the only country with a national surgical mortality audit. Every Australian surgical mortality is independently and externally reviewed by another surgeon. Extensive educational feedback to surgeons and hospitals is provided through individual patient reviews, state and national symposia and reports, and the distribution of deidentified informative cases. This study reports a longitudinal analysis of the Australian surgical morality audit.MethodsThe standardised mortality ratio (SMR) was calculated for each state and territory, nine surgical specialties and nationally. The index year used was 2016, or every 5 years for those states with earlier data. Overall data were analysed in three groups—all deaths, postoperative deaths and non‐operative deaths. Overall specialty data were analysed nationally.ResultsThere was a consistent progressive fall, usually in excess of 20%, in the SMR in each state and territory and by specialty when compared to the index year. This was statistically significant nationally (p = 0.044). The same change was observed in earlier years in states with longer‐term data.ConclusionThe period of this observational study has been associated with a nationwide fall in surgical mortality. As other improvements in care will have occurred during this period, the contribution that Australia's national mortality audit made towards the lower surgical mortality cannot be stated with certainty.
Cost optimisation of hybrid institutional incentives for promoting cooperation in finite populations
Authors: Duong M. H. , Durbac C. M. , Han T. A. 
Published: October 2023

AbstractIn this paper, we rigorously study the problem of cost optimisation of hybrid (mixed) institutional incentives, which are a plan of actions involving the use of reward and punishment by an external decision-maker, for maximising the level (or guaranteeing at least a certain level) of cooperative behaviour in a well-mixed, finite population of self-regarding individuals who interact via cooperation dilemmas (Donation Game or Public Goods Game). We show that a mixed incentive scheme can offer a more cost-efficient approach for providing incentives while ensuring the same level or standard of cooperation in the long-run. We establish the asymptotic behaviour (namely neutral drift, strong selection, and infinite-population limits). We prove the existence of a phase transition, obtaining the critical threshold of the strength of selection at which the monotonicity of the cost function changes and providing an algorithm for finding the optimal value of the individual incentive cost. Our analytical results are illustrated with numerical investigations. Overall, our analysis provides novel theoretical insights into the design of cost-efficient institutional incentive mechanisms for promoting the evolution of cooperation in stochastic systems.
On the Maximum of the Sum of the Sizes of Non-trivial Cross-Intersecting Families
Authors: Frankl P. 
Published: October 2023

AbstractLet $$n \ge 2k \ge 4$$

n
≥
2
k
≥
4

be integers, $${[n]\atopwithdelims ()k}$$

[
n
]

k

the collection of k-subsets of $$[n] = \{1, \ldots , n\}$$

[
n
]
=
{
1
,
…
,
n
}

. Two families $${\mathcal {F}}, {\mathcal {G}} \subset {[n]\atopwithdelims ()k}$$

F
,
G
⊂

[
n
]

k

are said to be cross-intersecting if $$F \cap G \ne \emptyset $$

F
∩
G
≠
∅

for all $$F \in {\mathcal {F}}$$

F
∈
F

and $$G \in {\mathcal {G}}$$

G
∈
G

. A family is called non-trivial if the intersection of all its members is empty. The best possible bound $$|{\mathcal {F}}| + |{\mathcal {G}}| \le {n \atopwithdelims ()k} - 2 {n - k\atopwithdelims ()k} + {n - 2k \atopwithdelims ()k} + 2$$

|
F
|

+

|
G
|

≤

n
k

-
2

n
-
k

k

+

n
-
2
k

k

+
2

is established under the assumption that $${\mathcal {F}}$$
F
and $${\mathcal {G}}$$
G
are non-trivial and cross-intersecting. For the proof a strengthened version of the so-called shifting technique is introduced. The most general result is Theorem 4.1.
Maternal Mental Health in the USA
Authors: Lamar Margaret R. , Donovan Courtney , Forbes Lisa K. 
Published: October 2023

AbstractMothers face enormous mental health challenges that need to be addressed by counsellors. Women have higher rates of depression, anxiety, and stress due to environmental, cultural, and biological factors. Findings from a sample of 525 US mothers showed that younger mothers had higher levels of stress, anxiety, and depression, while mothers with lower incomes showed higher levels of anxiety and depression. Results also indicated that fewer mothers have levels of stress, anxiety, and depression that fall into a normal range than a normal, non-clinical population and that substantially more mothers report extremely severe levels of stress, anxiety, and depression than normal, non-mother populations. Implications for counsellors include making services accessible to low-income mothers, attending to personal gender bias, and assessing clients for anxiety, depression, and stress.
The challenges of implementing antibiotic stewardship in diverse poultry value chains in Kenya
Authors: Hughes Alex , Roe Emma , Wambiya Elvis , Brown James A , Munthali Alister , Ziraba Abdhalah 
Published: October 2023

AbstractThis paper investigates the challenges of implementing antibiotic stewardship – reducing and optimizing the use of antibiotics – in agricultural settings of Low- and Middle-Income Countries (LMICs) as a strategic part of addressing the global problem of antimicrobial resistance (AMR). It does so through analysis of the rapidly transforming yet diverse Kenyan poultry sector, characterized by growing commercial operations alongside traditional smallholder farming. Our research involves interviews with farmers, processors, policymakers, and agro-veterinary stores in these settings. We blend Chandler’s (2019, p. 8) notion of “antibiotics as infrastructure” with value chain frameworks to understand how the structural role of antibiotics in agriculture plays out through contrasting value chains, with different implications for stewardship. Weak regulation and intense market-based pressures are shown to drive widespread antibiotic use in poultry value chains involving small- and medium-sized farms supplying open markets. Antibiotic stewardship through adherence to agricultural and food safety standards is more evident, though unevenly observed, in value chains involving large commercial farms and processors supplying corporate buyers. Our findings reveal the complex structural roles of antibiotics in maintaining producer livelihoods in an intensely competitive and heterogeneous Kenyan poultry sector. This highlights challenges with applying global AMR policy to transforming food systems in LMICs without appropriate translation. We argue that attempts to reduce and optimize the use of antibiotics in agriculture must be informed by nuanced understandings of the roles of antibiotics in food systems in specific places including where very different scales and models of farming and value chain co-exist.