bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape evolution in orogenic plateaus: Insights from quantitative morphotectonic analysis of the Turkish–Iranian Plateau and Caucasus regions
Authors: Kaveh‐Firouz Amaneh , Burg Jean‐Pierre , Giachetta Emanuele 
Published: December 2023

AbstractTo investigate the recent landscape evolution of the orogenic Turkish–Iranian Plateau (TIP) and the Lesser/Greater Caucasus ranges, we perform a quantitative analysis of topography and drainage networks at a regional scale. This analysis focuses on climatic–topographic swath profiles, local relief distribution, longitudinal river profiles, normalized channel steepness index (ksn), paleo‐river profile, and chi analysis (χ). In general, we find that the evolution of topographic relief and river networks are locally controlled by Late Cenozoic volcanism, contrasts in rock strength, and neotectonic activity along regional tectonic structures. However, our results show that the influence of these factors on the landscape evolution of the Greater Caucasus is significantly different from the Lesser Caucasus and TIP. This study shows that a combination of enhanced aridity, rapid uplift of orographic barriers along the TIP margins, and exposure of resistant rock types associated with the regional volcanic activity resulted in low‐relief plateau and the Lesser Caucasus surfaces that are preserved in the upper/middle Kura–Arax and Qezel‐Owzan river catchments. High local relief in the flanks of the Greater Caucasus and west Alborz, downstream increase in channel steepness, and perturbations in the χ plots of the three main rivers indicate that the topography is in a transient state.We reconstruct the paleo‐river profiles from the relict section of the upper Kura–Arax and Qezel‐Owzan rivers and show that the last drastic fall of the Caspian base‐level, which occurred during the Late Miocene–Early Pliocene, can explain the incision of ~500–1000 m gorges (i.e., Amardos) below major knickpoints. Furthermore, local cross‐divide differences of the χ parameter reveal that disequilibrium in the plan‐form geometry of the drainage networks, attributed to the upstream migration of the regional knickpoints towards the plateau interior and integration of plateau areas into the external fluvial system.
Study on the smoke evolution mechanism of a subway tunnel with a multi‐door carriage fire under longitudinal ventilation
Authors: Wu Zhenkun , Peng Min , Zhou Yun , Zhu Guoqing 
Published: December 2023

AbstractThis paper has analyzed the longitudinal ventilation on the effect of the efficiency of the smoke evolution mechanism in a metro tunnel of multi‐window carriage fires. These were simulated by Large Eddy Simulation (LES) with Fire Dynamics Simulator (FDS). In the past, analyses of smoke temperature under the tunnel ceiling and smoke overflow characteristics have been conducted. However, longitudinal ventilation has a different impact on temperature than natural ventilation, especially in a subway tunnel with a multi‐door carriage fire. Consequently, several simulations were run in a subway tunnel (360‐m long, 6.0‐m wide, and 4.8‐m high). The longitudinal ventilation velocity is set by 0–10 m/s with the heat release rate of 1–10 MW. The results show that there is a linear relationship between the maximum temperature and the longitudinal ventilation velocity. An empirical model considering various longitudinal ventilation velocities was developed to predict the maximum smoke temperature underneath the subway tunnel ceiling. The effects of the longitudinal ventilation velocity, the heat release rate, and the distance of the fire source on the characteristics of longitudinal temperature distribution were analyzed. What's more, smoke overflow characteristics under different longitudinal ventilation velocities have been described. The findings and results can also provide a reference for the fire risk assessment of a metro tunnel of multi‐window carriage fires.
Inulin‐type fructans with different degrees of polymerization improve insulin resistance, metabolic parameters, and hormonal status in overweight and obese women with polycystic ovary syndrome: A randomized double‐blind, placebo‐controlled clinical trial
Authors: Ziaei Rahele , Shahshahan Zahra , Ghasemi‐Tehrani Hatav , Heidari Zahra , Nehls Marilyn S. , Ghiasvand Reza 
Published: December 2023

AbstractPolycystic ovary syndrome (PCOS) is associated with reproductive disorders and adverse cardiometabolic risk factors that can negatively impact the general health of women. Inulin‐type fructans (ITFs) are proposed to beneficially affect risk factors associated with metabolic disorders. Whether ITFs can help with the management of PCOS by modifying insulin resistance (IR) and androgen levels has not yet been explored. The aim of this study was to investigate the effects of ITFs with different degrees of polymerization on insulin resistance, blood lipids, anthropometric measures, and hormonal status in overweight and obese women with PCOS. In a randomized double‐blind placebo‐controlled trial, seventy‐five women with PCOS aged 18–40 years old were randomly assigned to receive 10 g/day of high‐performance inulin (HPI) or oligofructose‐enriched inulin (OEI) or maltodextrin for 12 weeks. Biochemical and clinical outcomes were measured at baseline and after the intervention. Participants in the HPI and OEI groups experienced improvements in waist circumference, total testosterone, free androgen index, sex hormone‐binding globulin, and triglycerides compared to the placebo group. Also, the number of women with irregular menses or oligomenorrhoea decreased significantly in both ITF groups. Participants in the HPI group reported lower body mass, fasting insulin, and HOMA‐IR, as well as a higher quantitative insulin sensitivity check index. ITF supplementation, especially with long‐chain ITFs, when given for 12 weeks may improve metabolic outcomes, androgen status and clinical manifestations in women with PCOS.
Recentering the individual in context using the Phenomenological Variant of Ecological Systems Theory: Applications for higher education
Authors: Olson Avery B. , Ozaki Casey Carolyn , Johnston‐Guerrero Marc P. 
Published: December 2023

AbstractStudent development theory has been an important guide in practice; however, few theories focus on both the individual and the influence of the environment. Spencer's (1997) Phenomenological Variant of Ecological Systems Theory (PVEST) examines the individual, the environment, and the role of environmental feedback on self‐perceptions, with a specific focus on how this feedback influences student experiences and outcomes. PVEST allows for assessing the processes by which an individual can develop strategies to resist negative feedback from oppressive environments, as well as how individuals use different coping mechanisms. In this chapter, we apply PVEST to individual student‐level exemplars, as well as examples within counseling and classroom microcontexts to demonstrate the importance of environmental influence as well as phenomenological individual differences in interpretations and self‐perception. Ultimately, we demonstrate how PVEST is a theoretical mechanism to focus on both the person and their phenomenological experiences (PEs), and offer larger implications for use in higher education contexts.Practical Takeaways
While critical for student affairs (SA) and higher education (HE) practitioners to consider the influence of the environment on college student development, experiences, and outcomes, there can still be individual, subjective phenomenological differences across individuals who might share similar identities and be in similar contexts.
We encourage practitioners to utilize PVEST—which examines the individual and the environment—with a specific focus on the role of environmental feedback on self‐perceptions, and how these self‐perceptions can impact student experiences and outcomes.
PVEST is useful for understanding an individual's risk and protective factors, their available sources of challenge and support, and the coping mechanisms they use. Ultimately, PVEST can help a SA/HE practitioner assess processes by which the student can develop strategies to resist negative feedback from oppressive environments.
How Young Adult Literature Gets Taught: A review of a pedagogical manual for teacher educators, secondary teachers, and librarians
Authors: McKee Jared , Kellogg Geoffrey 
Published: December 2023

AbstractHow Young Adult Literature Gets Taught: Perspectives, Ideologies, and Pedagogical Approaches for Instruction and Assessment (Bickmore et al., 2022) seeks to provide guidelines for teacher educators and secondary English teachers on how to teach young adult literature (YAL). This 15‐chapter manual includes chapters written by experts in YAL (including higher ed professionals, a high school English teacher, and a librarian), which offer resources for teaching YAL based around various theoretical frameworks and include detailed reading lists, guided discussion questions, and more.
Modeling the polychromism of oxide minerals: The case of alexandrite and cordierite
Authors: Rullan Raphaël , Colinet Pauline , Desdion Quentin , Steinmann Stephan N. , Le Bahers Tangui 
Published: December 2023

AbstractIn this work, we investigate the spectroscopic properties of photochromic alexandrite and cordierite by TD‐DFT. The objective is to assess the TD‐DFT for the simulation of pleochroism (change of color depending on the crystallographic direction of the observation) and the change of color as a function of the light source. For these simulations, we compared an embedding where dangling bonds are saturated by hydrogen atoms and an electrostatic embedding. The electrostatic embedding provided numerically more stable results and allowed a good reproduction of the pleochroism of cordierite, based on a Fe2+‐Fe3+ intervalence charge transfer transition. However, the pleochroism of alexandrite is not as well reproduced, suggesting that TD‐DFT has some difficulties to reproduce the anisotropy of the transition dipole moment, an aspect that is not deeply documented in the literature.
A novel biomarker of fibrofatty replacement in dystrophinopathies identified by integrating transcriptome, magnetic resonance imaging, and pathology data
Authors: Xie Zhihao , Liu Chang , Sun Chengyue , Lu Yanyu , Wu Shiyi , Liu Yilin , Wang Qi , Wan Yalan , Wang Yikang , Yu Meng , Meng Lingchao , Deng Jianwen , Zhang Wei , Wang Zhaoxia , Yang Chunxia , Yuan Yun , Xie Zhiying 
Published: December 2023

AbstractBackgroundWe aimed to analyse genome‐wide transcriptome differences between Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) patients and identify biomarkers that correlate well with muscle magnetic resonance imaging (MRI) and histological fibrofatty replacement in both patients, which have not been reported.MethodsOne hundred and one male patients with dystrophinopathies (55 DMD and 46 BMD) were enrolled. Muscle‐derived genome‐wide RNA‐sequencing was performed in 31 DMD patients, 29 BMD patients, and 11 normal controls. Fibrofatty replacement was scored on muscle MRI and histological levels in all patients. A unique pipeline, single‐sample gene set enrichment analysis combined with Spearman's rank correlations (ssGSEA‐Cor) was developed to identify the most correlated gene signature for fibrofatty replacement. Quantitative real‐time PCR (qRT‐PCR) analysis, western blot analysis, and single‐nucleus RNA‐sequencing (snRNA‐seq) were performed in the remaining patients to validate the most correlated gene signature.ResultsComparative transcriptomic analysis revealed that 31 DMD muscles were characterized by a significant increase of inflammation/immune response and extracellular matrix remodelling compared with 29 BMD muscles (P < 0.05). The ssGSEA‐Cor pipeline revealed that the gene set of CDKN2A and CDKN2B was the most correlated gene signature for fibrofatty replacement (histological rs = 0.744, P < 0.001; MRI rs = 0.718, P < 0.001). Muscle qRT‐PCR confirmed that CDKN2A mRNA expression in both 15 DMD (median = 25.007, P < 0.001) and 12 BMD (median = 5.654, P < 0.001) patients were significantly higher than that in controls (median = 1.101), while no significant difference in CDKN2B mRNA expression was found among DMD, BMD, and control groups. In the 27 patients, muscle CDKN2A mRNA expression respectively correlated with muscle MRI (rs = 0.883, P < 0.001) and histological fibrofatty replacement (rs = 0.804, P < 0.001) and disease duration (rs = 0.645, P < 0.001) and North Star Ambulatory Assessment total scores (rs = −0.698, P < 0.001). Muscle western blot analysis confirmed that both four DMD (median = 2.958, P < 0.05) and four BMD (median = 1.959, P < 0.01) patients had a significantly higher level of CDKN2A protein expression than controls (median = 1.068). The snRNA‐seq analysis of two DMD muscles revealed that CDKN2A was mainly expressed in fibro‐adipogenic progenitors, satellite cells, and myoblasts.ConclusionsWe identify CDKN2A expression as a novel biomarker of fibrofatty replacement, which might be a new target for antifibrotic therapy in dystrophinopathies.
Preoperative Imaging Evaluation of Endometrial Cancer in FIGO 2023
Authors: Kido Aki , Himoto Yuki , Kurata Yasuhisa , Minamiguchi Sachiko , Nakamoto Yuji 
Published: December 2023

The staging of endometrial cancer is based on the International Federation of Gynecology and Obstetrics (FIGO) staging system according to the examination of surgical specimens, and has revised in 2023, 14 years after its last revision in 2009. Molecular and histological classification has incorporated to new FIGO system reflecting the biological behavior and prognosis of endometrial cancer. Nonetheless, the basic role of imaging modalities including ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography, as a preoperative assessment of the tumor extension and also the evaluation points in CT and MRI imaging are not changed, other than several point of local tumor extension. In the field of radiology, it has also undergone remarkable advancement through the rapid progress of computational technology. The application of deep learning reconstruction techniques contributes the benefits of shorter acquisition time or higher quality. Radiomics, which extract various quantitative features from the images, is also expected to have the potential for the quantitative prediction of risk factors such as histological types and lymphovascular space invasion, which is newly included in the new FIGO system. This article reviews the preoperative imaging diagnosis in new FIGO system and recent advances in imaging analysis and their clinical contributions in endometrial cancer.Evidence Level4Technical EfficacyStage 3
Abnormal Local Brain Activity and Cognitive Impairments in Young Non‐Disabled Patients With Intracerebral Hemorrhage: A Resting‐State Functional MRI Study
Authors: Yang Dan , Zhang Xue , Luo Xiangqi , Zhang Fengxia , Sun Shengjun , Shaocheng Liu , Zhao Xingquan , Zhou Jian 
Published: December 2023

BackgroundResting‐state functional MRI (rs‐fMRI) has identified static changes of local brain activity among patients with intracerebral hemorrhage (ICH). However, the dynamic and concordance‐related characteristics of brain activity remain unclear.PurposeTo investigate static, dynamic, and concordance‐related features of the regional brain activity of young non‐disabled ICH patients.Study TypeProspective.SubjectsThirty‐three ICH patients (modified Rankin Scale score ≤2, 21% female, 46.36 ± 6.53) and 33 matched healthy controls (HCs) (21% female, 47.64 ± 6.16).Field Strength/Sequence3‐T, rs‐fMRI using gradient echo‐planar imaging, T1‐weighted imaging.AssessmentNeuropsychological and rs‐fMRI data were acquired from all participants. Amplitude of low‐frequency fluctuations (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), voxel‐mirrored homotopic connectivity, global signal correlation (GSCorr) and degree centrality (DC), and their dynamic and concordance‐related changes with sliding window analysis were calculated based on rs‐fMRI data at a whole‐brain level. The burden of cerebral small vascular diseases (cSVD) was assessed by cSVD scores. All hemorrhage lesions were delineated on normalized T1 images.Statistical TestsMultiple regression models, a voxel‐level uncorrected P < 0.001, a cluster‐level false discovery rate (FDR) corrected q < 0.05, a re‐corrected qFDR <0.05 were considered significant. Pearson or Spearman correlation analyses between fMRI data and neurocognitive performance were performed.ResultsCompared to HCs, ICH patients showed significant abnormal changes of ALFF, dynamic ALFF, fALFF, ReHo, dynamic ReHo, GSCorr, DC, and voxel‐wise concordance in multiple brain regions mainly including the bilateral cerebellar hemispheres, ipsilesional thalamus, and bilateral middle cingulum gyrus. The ALFF in the cerebellar posterior lobe and thalamus were significantly associated with attention (r = −0.481) and executive function (rho = −0.521) in ICH patients.Data ConclusionYoung non‐disabled ICH patients exhibit static, dynamic, and concordance‐related alterations of local brain activity, part of which shows associations with cognitive functions. These findings may help comprehensively understand the mechanism of cognitive impairment after ICH.Level of Evidence2Technical EfficacyStage 3
Does deprotonated benzoic acid lose carbon monoxide in collision‐induced dissociation?
Authors: Liu Yingying , Wang Xue , Zhang Danyang , Wang Chen , Xie Haijiao , Chen Hongping , Chai Yunfeng 
Published: December 2023

AbstractDecarboxylation is known to be the major fragmentation pathway for the deprotonated carboxylic acids in collision‐induced dissociation (CID). However, in the CID mass spectrum of deprotonated benzoic acid (m/z 121) recorded on a Q‐orbitrap mass spectrometer, the dominant peak was found to be m/z 93 instead of the anticipated m/z 77. Based on theoretical calculations, 18O‐isotope labeling and MS3 experiments, we demonstrated that the fragmentation of benzoate anion begins with decarboxylation, but the initial phenide anion (m/z 77) can react with trace O2 in the mass analyzer to produce phenolate anion (m/z 93) and other oxygen‐containing ions. Thus oxygen adducts should be considered when annotating the MS/MS spectra of benzoic acids.
Effect of mechanical properties on in vitro dynamic digestion of starch contained in hydrogels
Authors: Wang Zaitian , Kozu Hiroyuki , Uemura Kunihiko , Kobayashi Isao , Ichikawa Sosaku 
Published: December 2023

AbstractBACKGROUNDThis study evaluates the effect of mechanical properties on the in vitro dynamic gastrointestinal digestion of hydrogels containing starch (HCSs) as a model for studying the nutrient digestibility of solid foods. It provides a useful theoretical basis for the processing of specific foods.RESULTFour types of HCSs with two levels of fracture stress (17.4–20.9 kPa and 55.5–57.6 kPa) and two levels of fracture strain (25.4–28.5% and 53.7–57.4%) were prepared. For these HCSs, the degree of gastric disintegration of hydrogels reduced significantly when fracture strain exceeded 30% (P < 0.05). The gastric emptying of HCS particles was also affected by mechanical properties. For example, even at the same level of fracture stress (ca. 20 kPa), the dry solids retention ratio decreased markedly from 0.90 to 0.43 with a decrease in fracture strain from 53.7% to 25.4% (P < 0.05). For the starch hydrolysis of HCSs after gastric digestion, more than 70% of starch in the particles of all types of HCSs emptied did not undergo digestion. The starch hydrolysis of HCSs during small intestinal digestion was also influenced by their mechanical properties. Fracture strains of HCSs, rather than their fracture stress, affected starch digestibility in hydrogels.CONCLUSIONThe gastric disintegration, the gastric emptying, and the starch hydrolysis of HCSs are suppressed when fracture strain exceeded 30%. Even with the amount of nutritional components contained in hydrogels being the same, the in vitro gastrointestinal digestion behavior of HCSs depends on their mechanical properties. This behavior has the potential to be used in the design of processed foods with controlled bioaccessibility. © 2023 Society of Chemical Industry.
Postoperative Care of Zenker Diverticula: Contemporary Perspective from the Prospective OUtcomes Cricopharyngeaus Hypertonicity (POUCH) Collaborative
Authors: McKeon Mallory , McCoy Nicole , Johnson Christopher , Allen Jacqui , Altaye Mekibib , Amin Milan , Bayan Semirra , Belafsky Peter , DeSilva Brad , Dion Greg , Ekbom Dale , Friedman Aaron , Fritz Mark , Giliberto John Paul , Guardiani Elizabeth , Kasperbauer Jan , Kim Brandon , Krekeler Brittany N. , Kuhn Maggie , Kwak Paul , Ma Yue , Madden Lyndsay L. , Matrka Laura , Mayerhoff Ross , Piraka Cyrus , Rosen Clark A. , Tabangin Meredith , Wahab Shaun , Wilson Keith , Wright Carter , Young VyVy N. , Postma Gregory , Howell Rebecca J. 
Published: December 2023

ObjectivesThe aim of the study was to identify trends in postoperative management of persons undergoing surgery for Zenker diverticula (ZD) by evaluating length of stay (LOS), diet on discharge, and imaging with or without surgical complication.MethodsProspectively enrolled adult patients with cricopharyngeal muscle dysfunction with diverticula undergoing surgery from August 1, 2017 to February 1, 2023 were included. Data were extracted from a multi‐institutional REDCap database, summarizing means, medians, percentages, and frequencies. Fisher's exact or chi squared analyses were utilized, as appropriate, to compare subsets of data. Descriptive analysis assessed differences in clinical course and the relationship to postoperative management.ResultsThere were 298 patients with a mean (standard deviation) age of 71.8 (11.2) years and 60% male. Endoscopic surgery was performed in 79.5% (237/298) of patients versus 20.5% (61/298) open surgery. Sixty patients (20.1%) received postoperative imaging, with four leaks identified. Complications were identified in 9.4% of cases (n = 29 complications in 28 patients), more commonly in open surgery. Most (81.2%) patients were discharged within 23 h. About half of patients (49%) were discharged from the hospital on a pureed/liquid diet; 36% had been advanced to a soft diet. In patients without complications, LOS was significantly longer following open cases (p = 0.002); postoperative diet was not different between open and endoscopic (p = 0.26).ConclusionsOverall, most patients are discharged within 23 h without imaging. However, LOS was affected by surgical approach. Postoperative complications are different in endoscopic versus open surgery. Complications with either approach were associated with prolonged LOS, need for imaging, and diet restriction.Level of EvidenceLevel III Laryngoscope, 134:2678–2683, 2024