bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual reality in managing dental pain and anxiety: a comprehensive review
Authors: Fan Lin , Zeng Jie , Ran Longkuan , Zhang Chao , Wang Jing , Yu Cong , Zhao Nan 
Published: December 2023

ObjectivesThis study aimed to identify, analyze, and summarize the clinical efficacy of virtual reality (VR) distraction therapy for oral treatment in different hospital settings in contrast to medical interventions that induce anxiety and pain. Furthermore, this review aimed to determine the implications for research and clinical practice of VR distraction therapy.DataThis review investigated the clinical efficacy of VR in the oral treatment of procedural pain or anxiety. Quality assessment of the included studies was conducted. A narrative synthesis of the collected data was performed.SourcesLiterature studies from six electronic databases were searched for a comprehensive review, namely, the Cochrane Oral Health’s Trials Register, Cochrane Central Register of Controlled Trials (Central), MEDLINE (PubMed), EMBASE, Scopus, and Web of Science.Study selectionOne thousand five hundred twenty-two patients aged between 0 and 60 years who used VR during dental treatment were included in this review. Among these studies, 8 and 14 studies comprised adult and pediatric patients.ConclusionOverall, the reviewed studies underscore the efficacy of VR to mitigate pain and anxiety in the context of dental treatment. VR is an innovative pain and anxiety management approach that facilitates dental treatment patients to immerse themselves in a virtual world while using distractions to reduce pain and anxiety.Clinical significanceVR is an effective and novel non-pharmacological method of behavioral management that contributes to improving medication safety for dental patients. VR as a distractive approach can reduce the fear associated with medical interventions and prevent severe pain sensitivity, anxiety, and medical avoidance among adults and children.
Percutaneous ballon compression for recurrent TN —a retrospective study of 33 cases
Authors: Feng Dongwei , Zhang Yaxin , Li Dong , Wang Kang , Yang Fan , Ding Jianan , Wu Weize , Wang Yunhe , Jia Heping 
Published: December 2023

ObjectiveTo investigate the clinical efficacy of percutaneous microballoon compression in the treatment of recurrent TN.MethodsThis retrospective study included 33 patients who underwent percutaneous microballoon compression for the treatment of recurrent TN from March 2019 to May 2022. Postoperative pain recurrence and facial numbness were assessed according to the Barrow Neurological Institute (BNI) pain score. Patients’ anxiety and sleep status during follow-up were assessed according to the Self-rating Anxiety Scale (SAS) and Pittsburgh Sleep Quality Index (PSQI).ResultsAll patients (33 cases) were followed up for 12–38 months, with an average follow-up time of 23 months. On postoperative day 1, 31 patients (93.9%) reported no pain, and 2 patients were given drug treatment for pain relief, The total efficacy was 93.9%. Moreover, 2 patients (6.1%) reported significant pain relief 2 weeks postoperatively. There are many complications during and after PBC. The incidence of the trigeminocardiac reflex (TCR) during surgery was 100%, and the incidence of facial numbness, masseter muscle weakness, labial herpes and headache was 97, 60.6, 12.1 and 3%. No patient experienced severe facial numbness, hearing impairment, diplopia, injury to cranial nerves, Meningitis, intracranial haemorrhage or keratitis. 1 patient had recurrence of pain at 6 months post-op, which was relieved by oral medication. 81.8% suffered from anxiety and 54.5% had poor sleep quality before surgery. After the period of PBC, SAS and PSQI scores decreased continuously. There were significant improvements in anxiety and sleep status postoperatively compared with preoperatively.ConclusionPBC is a safe and effective option for the treatment of recurrent TN. The arduous and demanding nature of the clinical course subjects the patient to severe pain, mental, and physical stress. Thankfully, it significantly improves the symptoms of anxiety, depression, and sleep quality.
The impact of characters like Tony the Tiger and other child-targeted techniques used in food and beverage marketing
Authors: Mulligan Christine , Remedios Lauren , Ramsay Tim , Pauzé Elise , Bagnato Mariangela , Potvin Kent Monique 
Published: December 2023

IntroductionFood marketing’s impact is a function of exposure and power, both of which contribute to children’s poor diet quality and obesity risk. Children’s exposure to food marketing is well documented, however, few studies have assessed the impact of specific persuasive marketing techniques or aspects of ‘power’ on children.MethodsThis study administered an online survey to 1,341 Canadian children (9–12 years) aiming to determine the impact of: (1) child-targeted vs. adult-targeted marketing, and (2) licensed characters vs. spokes characters on children’s food preferences and behavioral intentions. Participants were randomized to a single condition in each survey part and viewed 3 static food advertisements displaying the features of that condition (e.g., child-targeted advertising or licensed characters), and answered 3 Likert-scale (5-point) questions after each exposure. For each condition within each research question, there were four outcome variables related to the impact of marketing on children: food preference, purchase intent, pester power, and total impact. ANOVA tested the difference in impact (Likert scores) between conditions overall and for each outcome, with Bonferroni post-hoc tests where necessary.ResultsA greater average total impact was observed among children exposed to child-targeted ads (mean Likert score 3.36) vs. adult-targeted ads (mean score 2.75; p &lt; 0.001) or no marketing (mean score 2.81; p &lt; 0.001). Children exposed to ads featuring spokes characters had a higher average total impact (mean score 3.98) vs. licensed characters (mean score 3.80; p &lt; 0.001) and the control (i.e., no characters) (mean score 3.19; p &lt; 0.001), and the total impact of licensed characters was greater than that of no characters. Similar trends were observed for all other outcomes.DiscussionOverall, this study showed that child-targeted ads and those using characters - especially spokes characters - have a strong overall impact on children’s food preferences, purchase intents, and pester power, and support the implementation of comprehensive marketing restrictions to protect children.
Characterization of wooden breast myopathy: a focus on syndecans and ECM remodeling
Authors: Pejšková Lucie , Rønning Sissel Beate , Kent Matthew Peter , Solberg Nina Therese , Høst Vibeke , Thu-Hien To , Wold Jens Petter , Lunde Marianne , Mosleth Ellen , Pisconti Addolorata , Kolset Svein Olav , Carlson Cathrine Rein , Pedersen Mona Elisabeth 
Published: December 2023

Introduction: The skeletal muscle deformity of commercial chickens (Gallus gallus), known as the wooden breast (WB), is associated with fibrotic myopathy of unknown etiology. For future breeding strategies and genetic improvements, it is essential to identify the molecular mechanisms underlying the phenotype. The pathophysiological hallmarks of WB include severe skeletal muscle fibrosis, inflammation, myofiber necrosis, and multifocal degeneration of muscle tissue. The transmembrane proteoglycans syndecans have a wide spectrum of biological functions and are master regulators of tissue homeostasis. They are upregulated and shed (cleaved) as a regulatory mechanism during tissue repair and regeneration. During the last decades, it has become clear that the syndecan family also has critical functions in skeletal muscle growth, however, their potential involvement in WB pathogenesis is unknown.Methods: In this study, we have categorized four groups of WB myopathy in broiler chickens and performed a comprehensive characterization of the molecular and histological profiles of two of them, with a special focus on the role of the syndecans and remodeling of the extracellular matrix (ECM).Results and discussion: Our findings reveal differential expression and shedding of the four syndecan family members and increased matrix metalloproteinase activity. Additionally, we identified alterations in key signaling pathways such as MAPK, AKT, and Wnt. Our work provides novel insights into a deeper understanding of WB pathogenesis and suggests potential therapeutic targets for this condition.
Barriers to HPV vaccination in marginalized Roma communities in Slovakia
Authors: Filakovska Bobakova Daniela , Plavnicka Jana , Urbancikova Ingrid , Edelstein Michael , Jansen Danielle , Dankulincova Veselska Zuzana 
Published: December 2023

IntroductionLimited access to healthcare services leads to lower vaccination rates in marginalized Roma communities (MRCs). This study aimed to explore health system barriers to HPV vaccination faced by people from MRCs from multiple perspectives.MethodsThe qualitative study was conducted in Slovakia in 2021/22 with 43 community members and health professionals. Data were analyzed using a combination of content analysis and consensual qualitative research.ResultsA substantial barrier to vaccination is limited coverage of vaccination expenses for certain age categories by health insurance. Moreover, Slovakia faces a significant shortage of healthcare personnel, leading to work overload and a lack of capacity and motivation to address HPV vaccination. Impaired relationships between health care providers and people from MRCs lead to the avoidance of healthcare services, which contributes to insufficient delivery of information and a lack of awareness regarding HPV-related diseases and vaccination.ConclusionStrengthening the capacities of health care providers, expanding the age group covered by health insurance and providing tailored information to people from MRCs are necessary prerequisites to increase the availability of HPV vaccination and enable people to make informed decisions about HPV vaccination.
Frailty and medication adherence among older adult patients with hypertension: a moderated mediation model
Authors: Wang Anshi , Wan Jingjing , Zhu Lijun , Chang Weiwei , Wen Liying , Tao Xiubin , Jin Yuelong 
Published: December 2023

ObjectiveMedication adherence has a critical impact on the well-being of older adult patients with hypertension. As such, the current study aimed to investigate the mediating role of health literacy between frailty and medication adherence and the moderating role of educational level.MethodsThis cross-sectional study included patients admitted to the geriatric unit of a hospital. Participants were interviewed using the four-item Morisky Medication Adherence Scale, the Frailty Phenotype Scale, and the Health Literacy Management Scale. Spearman’s correlation coefficients were used to assess the association between variables. Mediation and moderated mediation analyses were performed using Process version 4.1 via Model 4 and 14, respectively.ResultsData from 388 participants were analyzed. The median (IQR [P25–P75]) score for medication adherence was 4.00 (2.00–4.00). Results revealed that after controlling for age, sex, hypertension complication(s) and body mass index, frailty significantly contributed to medication adherence (βtotal −0.236 [95% confidence interval (CI) −0.333 to −0.140]). Medication adherence was influenced by frailty (βdirect −0.192 [95% CI −0.284 to −0.099]) both directly and indirectly through health literacy (βindirect −0.044 [95% CI −0.077 to −0.014]). Educational level moderated the pathway mediated by health literacy; more specifically, the conditional indirect effect between frailty and medication adherence was significant among older adult hypertensive patients with low, intermediate, and high educational levels (effect −0.052 [95% CI −0.092 to −0.106]; effect −0.041 [95% CI −0.071 to −0.012]; effect −0.026 [95% CI −0.051 to −0.006]). The relationship between frailty and medication adherence in older adult patients with hypertension was found to have mediating and moderating effects.ConclusionA moderated mediation model was proposed to investigate the effect of frailty on medication adherence. It was effective in strengthening medication adherence by improving health literacy and reducing frailty. More attention needs to be devoted to older adult patients with hypertension and low educational levels.
Investigating the Stirred Tank Bioreactor Co-Cultures of the Secondary Metabolite Producers Streptomyces noursei and Penicillium rubens
Authors: Boruta Tomasz , Ścigaczewska Anna , Bizukojć Marcin 
Published: December 2023

The stirred tank bioreactor co-cultures of the filamentous fungus Penicillium rubens and actinomycete Streptomyces noursei were studied with regard to secondary metabolite (SM) production, sugar consumption, and dissolved oxygen levels. In addition to the quantitative analysis of penicillin G and nystatin A1, the broad repertoire of 22 putatively identified products was semi-quantitatively evaluated with the use of UPLC-MS. Three co-cultivation variants differing with respect to the co-culture initiation method (i.e., the simultaneous inoculation of P. rubens and S. noursei and the 24 or 48 h inoculation delay of S. noursei relative to P. rubens) were investigated. All the co-cultures were carried out in parallel with the corresponding monoculture controls. Even though S. noursei showed the tendency to outperform P. rubens and inhibit the production of fungal secondary metabolites, the approach of simultaneous inoculation was effective in terms of enhancing the production of some S. noursei SMs, namely desferrioxamine E, deshydroxynocardamine, and argvalin. S. noursei displayed the capability of adaptation and SM production even after being inoculated into the 24 or 48 h culture of P. rubens. Interestingly, S. noursei turned out to be more efficient in terms of secondary metabolite production when its inoculation time relative to P. rubens was delayed by 48 h rather than by 24 h. The study demonstrated that the prolongation of inoculation delays can be beneficial for production-related performance in some co-culture systems.
Natural Vector of Avian Haemoproteus asymmetricus Parasite and Factors Altering the Spread of Infection
Authors: Žiegytė Rita , Palinauskas Vaidas , Bernotienė Rasa 
Published: December 2023

Avian haemosporidians (Apicomplexa, Haemosporida) are widespread blood protists, often causing severe haemosporidiosis, pathology, or even mortality in their hosts. Migrant birds regularly bring various haemosporidian parasites from wintering grounds to European breeding areas. Some haemosporidian parasites are prevalent in breeding sites and complete their life cycles in temperate climate zones and can be transmitted, but others do not. The factors altering the spread of these haemosporidians are not fully understood. Culicoides biting midges (Diptera: Ceratopogonidae) play an important role in the transmission of worldwide distributed avian haemosporidian parasites belonging to the genus Haemoproteus, but this information is particularly scarce and insufficient. The key factors limiting the spread of these pathogens in temperate climate zones, which we suspect and aim to study, are the absence of susceptible vectors and the ecological isolation of birds from vectors during the breeding period when transmission occurs. The primary objective of this study was to evaluate how the habitats of biting midges and bird breeding sites influence parasite transmission while also seeking to expand our understanding of the natural vectors for these parasites. Biting midges were collected using UV traps on the Curonian Spit, Lithuania, in different habitats, such as woodland and reeds, from May to September. Parous Culicoides females were identified, dissected, and investigated for the presence of Haemoproteus parasites using both microscopy and PCR-based tools. Among the dissected 1135 parous Culicoides females, the sporozoites of Haemoproteus asymmetricus (genetic lineage hTUPHI01) have been detected for the first time in the salivary glands of Culicoides festivipennis. The sporozoites of four Haemoproteus lineages were detected in Culicoides segnis, C. festivipennis, and Culicoides kibunensis biting midges. PCR-based screening showed that the females of seven Culicoides species were naturally infected with Haemoproteus parasites. The DNA of the parasite of owls, Haemoproteus syrnii (hSTAL2), was detected for the first time in Culicoides punctatus. The highest abundance of collected Culicoides females was in June, but the highest prevalence of Haemoproteus parasites in biting midges was in July. The abundance of Culicoides was higher in the woodland compared with reeds during the season. The acquired findings indicate the varied abundance and diversity of biting midges throughout the season and across distinct habitats. This variability could potentially impact the transmission of Haemoproteus parasites among birds with diverse breeding site ecologies. These outcomes hold the potential to enhance our understanding of the epizootiology of Haemoproteus infections within temperate climatic zones.
MENINGKATKAN PERLINDUNGAN INVESTOR DALAM USAHA HULU MINYAK DAN GAS BUMI DALAM KONTEKS INDONESIA
Authors: - Mardianto , Pieris John , Widiarty Wiwik S. 
Published: December 2023

The primary objective of this research is to assess the degree of legal assurance and protection accessible to investors involved in upstream oil and gas operations within the Republic of Indonesia's jurisdiction. The goal is to offer valuable insights to relevant decision-makers and stakeholders, aiming to enhance the legal assurance and protection afforded to investors in this sector, thereby contributing to the nation's overall stability. The research methodology employed in this study is normative and qualitative juridical legal research, incorporating statutory and conceptual approaches. The research findings highlight the necessity for legislative enhancements, particularly implementing the Job Creation Law. This legislation will enhance the regulatory framework, ensuring legal assurance under Article 169, Section A of the Minerba Law. This provision stresses that holders of Mining Business Permits (KK) should not encounter premature contract terminations and advocates for rigorous law enforcement in cases of violations. Furthermore, the study acknowledges the significance of Law No. 25 of 2007, which safeguards legal and business assurance for investors, notably through the Omnibus Law.
Amanda Arias: Una maestra que no quiso ser paradigma de nada (Santa Fe, primera mitad del siglo XX)
Authors: Pellegrini Malpiedi Micaela 
Published: December 2023

Desde un enfoque que pone en diálogo a la historia sociocultural de la educación y la historia de/con mujeres en perspectiva de género, el siguiente artículo funda una serie de líneas de análisis alrededor de la trayectoria docente de la argentina Amanda Arias (1930-1955) y los intercambios, enfrentamientos y tretas de la misma, con agentes del sistema educativo y parte de la elite de su localidad, Rafaela.
En específico, este artículo sostiene que, al mirar microscópicamente las trayectorias de diferentes mujeres que habitaron las escuelas, es posible tender puentes para interpretar situaciones experienciales que ponen en evidencia problemáticas del sistema educativo argentino más generales, como por ejemplo, las lógicas patriarcales de los actores sociales que lo ocuparon, las implicancias de la sociedad civil en el sostenimiento de las instituciones educativas, o el ejercicio de la burocracia escolar, entre otras.
Aménagements contractuels de la condition suspensive légale d’obtention d’un prêt immobilier : ce qui est licite et ce qui lie le bénéficiaire de la condition
Authors: Pierre Nathalie 
Published: December 2023

Solution - La présente décision s’inscrit de manière intéressante dans le contentieux toujours nourri lié à la condition suspensive d’obtention d’un prêt immobilier (art. L 313-41 du Code de la consommation). Dans un arrêt très riche, la cour estime d’une part que la clause imposant au consommateur, bénéficiaire de la condition légale, de déposer la demande de prêt dans un délai au moins égal à un mois est licite. Elle considère d’autre part que la demande de financement à un taux inférieur au taux maximal défini dans l’acte est conforme aux caractéristiques contractuelles du prêt, la condition n’étant dès lors pas réputée accomplie.
Aménager ab initio une courte peine d’emprisonnement malgré l’absence du prévenu à l’audience, et d’éléments qualitatifs dans le dossier, c’est non !
Authors: Ratineau Yannick 
Published: December 2023

En l’absence du prévenu à l’audience, et d’éléments suffisants sur sa personnalité et sa situation, la 6e chambre des appels correctionnels refuse d’aménager ab initio une peine de deux mois d’emprisonnement, en violation de la solution de principe posée par la chambre criminelle de la Cour de cassation dans plusieurs arrêts rendus au printemps 2021.
«  Nulle terre sans guerre  » : succession, exploitation agricole et conflits familiaux
Authors: Akkas Yeliz 
Published: December 2023

Dans son arrêt du 16 mars 2022, la Cour d’appel de Grenoble apporte une intéressante illustration des différends familiaux susceptibles de survenir lors du règlement de la succession de l’épouse d’un exploitant agricole. Elle confirme la validité d’un testament olographe et déboute les demandes relatives à l’attribution préférentielle, aux salaires différés et au rapport à la succession des primes d’assurance-vie.
Formation of priority points of industrial growth under sanctions pressure as a direction of techno-economy development
Authors: Klevtsova M. G. , Polozhentseva Yu. S. , Chaplygina V. A. 
Published: December 2023

Aim. To determine the priority points of industry growth in the Russian Federation (RF) as an instrument of techno-economy development in the conditions of unstable external environment and sanctions pressure.Objectives. To substantiate the necessity of developing own technologies in industry in the turbulent macroeconomic environment; to identify the leading industries of the Russian Federation on the basis of comparative analysis; to analyze the possibility of network effect in the development of industry growth points; to determine the relationship between external sanctions pressure on priority industries and the specifics of the development of these industries-growth points.Methods. Theoretical and methodological generalizations were made using general methods of economic analysis: historical and logical, monographic and abstraction methods. In the practical component of the research economic and mathematical modeling, correlation and regression analysis technologies, matrix approach were used.Results. The development of such a direction as technoeconomics during the period of sanctions pressure allows industries to adapt to new conditions. In the process of analysis the main points of growth for the industrial sector of the Russian Federation were identified: production of medicines and materials used for medical purposes; production of computers, electronic and optical products, machinery and equipment. The high value of links within each industry and, accordingly, the possibility of the network effect was determined. Models reflecting the relationship between the functioning of industry growth points and the factors of industry development during the period of sanctions pressure were built.Conclusions. Today it is necessary to invest in the innovative potential of individual sub-sectors of industry (growth points) and develop industries that support the functioning of techno-economy and contribute to the formation of the network effect. Industries of this type have an additional positive impact on the development of the economy and contribute to the acceleration of adaptation processes, increase the productivity of industries in the turbulence of the external environment and sanctions pressure.