bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELATIONSHIP BETWEEN SHELTERIN PROTEINS AND AGMATINE IN URINARY TRACT INFECTIONS
Authors: BEDİR Mustafa Doğan , BAKIR Sevtap , ENGİN Aynur 
Published: December 2023

Abstract: The presence of microorganisms in the kidney, collecting system, or bladder with pyuria and clinical symptoms is called Urinary Tract Infection (UTI). UTI is one of the most common diseases in both nosocomial and community-acquired infections and affects millions of people every year. The clinical types of UTI range from cystitis to sepsis. In this study, we aimed to contribute to the literature by comparing the levels of shelterin proteins and agmatine in the serum of patients diagnosed with cystitis, one of the types of UTI, and healthy volunteers without any known medical disorder, and to bring new approaches to issues such as clinical severity, response to treatment, and pathogenesis of the disease.
Methods: In this study, 30 individuals diagnosed with cystitis from UTIs and 30 individuals without any systemic disease participated. Serum agmatine levels were measured by a fluorescence detector using the ultra-high-performance liquid chromatography method (UHPLC). Serum shelterin proteins levels were measured using the ELISA method.
Results: When the patients and healthy controls were compared, serum Telomeric Repeat Binding Factor2 (TRF2) levels of the patients were found to be lower than the controls; serum agmatine levels were found to be higher than the controls and statistically significant (p0.05).
Conclusion: In conclusion, the statistically significant difference in serum TRF2 and agmatine levels between the groups may be associated with oxidative stress. It is thought that the shortening of telomere lengths may be associated with decreased TRF2 levels.
Thrombophilic gene variants in patients with coronary artery disease and myocardial infarction
Authors: YILDIRIM Malik Ejder 
Published: December 2023

Background and aim: Coronary artery disease (CAD) and myocardial infarction (MI) are cardiovascular diseases that occur due to atherosclerosis (plaque formation) or atherosclerotic obstruction of the coronary arteries. Their genetic basis has been under investigation for a long time, and common variant studies link different genetic loci with these diseases. In this study, we investigated the possible association of coronary artery disease and myocardial infarction with thrombophilic gene variants, including MTHFR C677T and A1298C, Beta fibrinogen -455G/A, Factor XIIIV34L and PAI-1 4G/5G single nucleotide polymorphisms (SNPs).
Methods: A total of 128 people (64 patients and 64 controls) were included in the study. Genomic DNA was isolated using the EZ1 blood mini kit. The DNA was amplified and PCR was performed using the PyroMark PCR Kit (Qiagen, Germany). Pyrosequencing reaction was completed by processing with PyroMark Q24 instrument.
Results: We found that the PAI-1 4G/5G polymorphism and the 4G allele were significantly associated with coronary artery disease and myocardial infarction (P= 0.01). Although mutant variants were higher in patients, no statistically significant difference was observed between the patient and control groups in terms of FXIII, Beta-fibrinogen and MTHFR variants.
Conclusions: It is clear that the PAI-1 4G allele and the 4G/4G genotype have a significant contribution to the development of coronary artery disease and ultimately myocardial infarction. Prophylactic treatment should be considered in patients with this variant.
FORENSIC MEDICAL PERSPECTIVE OF ELDER ABUSE
Authors: YÜCEL BEYAZTAŞ Fatma , BUTUN Celal , KURT Gökhan 
Published: December 2023

The issue of elder abuse and neglect is an important public health problem that requires urgent attention from social assistance institutions, health systems, political institutions and citizens, can create devastating individual and social consequences, and is not unfortunately adequately reported. Elder abuse can cause serious consequences on both mental and physical health, such as injury, death, anxiety, depression, substance addiction, and suicide.
Necessary precautions should be taken to prevent elder abuse. First of all, it is very important to raise awareness of elder abuse and to raise awareness of the entire society on this issue.
Is the Safe Cholecystectomy Technique Really Safe?
Authors: SOYLU Sinan 
Published: December 2023

Aim: This study aims to present the results of a single surgeon's experience to demonstrate the effectiveness of the 'Critical View of Safety' (CVS) technique in preventing bile duct injuries in clinical practice.
Method: We retrospectively reviewed the records of 899 patients who underwent cholecystectomy using the CVS technique performed by a single surgeon at the Sivas Cumhuriyet University Hospital General Surgery Department between 2018 and 2023. Ethical approval for the study was obtained. Cholecystectomy cases were scanned retrospectively. The patients' age, gender, drain placement, surgery indications, and reason for switching to open cholecystectomy were recorded.
Results: Among the 899 patients reviewed, 312 were male (34.70%), and 587 were female (65.30%). The average age was 55.10 for males and 51,65 for females. It was determined that 7(0.77%), cases converted to open cholecystectomy. The most common indication for cholecystectomy was elective gallbladder stone removal, accounting for 47.05% of cases. No major bile duct injuries were detected..
Conclusions: The safe cholecystectomy technique can be safely applied to avoid bile duct injuries in laparoscopic cholecystectomy.
Effects of Zaï Pit Depth on Morphological Traits, Yield Components and Yield of Cowpea (Vigna unguiculata (L.) Walp) in Burkina Faso
Authors: Célestin Thiombiano , Adulrahman Lado , Soumabere Coulibaly , Idriss Serme , Joseph Batieno T. Benoit , Zakaria Dieni , Salle Tignegre J. B. De la , Hussaini M. A. 
Published: December 2023

Cowpea is the leading food legume for many households in arid and semi-arid regions of Sub-Saharan Africa. The erratic rainfall leads to decrease in cowpea yield. The Zaï pit technology is an ancestral agricultural technique used for water and fertilizer management in crops production increasing productivity. A study was carried out in Burkina Faso during 2020 and 2021 dry season at Kamboinsin and at Kouare with for objective of evaluating the effects of Zaï depth on cowpea yield and yield components. Treatments consisted of the use of three Zaï depths (control (tillage); 15 cm; 25 cm) and four cowpea varieties. The experimental design used was a split-plot replicated three times. Yield and yield components data were collected and subjected to an analysis of variance using JMP Pro 10 software. The results showed that for all the studied varieties, all the yield components and yields average values increased with the Zaï pit depth. Zaï of 25 cm and 15 cm depth increased cowpea grain yield of more than 87% and 50% respectively compared to the control (tillage). Twenty-five-centimetre Zaï depth substantially enhances cowpea agronomical performances and is recommendable for cowpea production in drought prone regions or of low rainfall.
Accounting Measurement and Profitability: Comparative Analysis between Fair Value Regime and Historical Cost Regime
Authors: Aremu Paul Olabode, , Owolabi Sunday Ajao, 
Published: December 2023

This study examined the effect of accounting measurement on profitability of selected consumer goods companies in Nigeria during historical cost regime and fair value regime. Accounting measurement was measured with revenue, cost of sales and operating cost while profitability was measured with net profit margin and return on equity. The data were generated from the annual reports of ten (10) selected consumer goods companies listed on the Nigeria stock exchange from 2008-2010 (representing historical cost regimes) and 2019-2021 (representing fair value regimes). The consumer goods companies used for this study included Dangote Sugar, Nigeria Breweries, Nestle, Guinness, Cadbury, Unilever, Nascon, Pz Cursors, Floor Mill and Honeywell.
Hausman test was conducted and the result led to the use of fixed effect estimation technique for testing the hypotheses. Regression result showed that cost of sale and operating cost have negative effect on net profit margin both on both historical cost and fair value regime while revenue has significant positive effect on net profit margin both on historical cost and fair value regime. Furthermore, cost of sales and operating cost have negative significant effect on return on equity both on historical cost and fair value while revenue has significant positive effect on return on equity both on historical cost and fair value.
The study concluded that both fair value and historical cost measurement have positive significant effect on net profit margin and return on equity. This implies that profitability is not a function of either fair value or historical cost accounting measurement. The study recommended that fair value accounting basis should be adopted in order to ensure a more realistic measure of profitability than under historical cost basis.
Forecasting Australia Gross Domestic Product (GDP) under Structural Change (SC) Using Break for Time Series Components (BFTSC)
Authors: Oloruntoba Ajare Emmanuel , Adekunle Adefabi , Abiodun Adeyemo 
Published: December 2023

The reason for this research is to enable us know the use BFTSC (break for time series components) in identification of the structural change and the time series components existing in Australia GDP. The data (Australia GDP) statistics spanned for period of fifty five years. The GDP of Australia is a higher information gotten from the StreamData of Universiti Utara Malaysia Library. The precincts of BFAST in terms of structural change was advanced to become BFTSC. BFTSC was created from basic research conducted on BFAST, results shows an innovative technique that captures the recurring (cyclicals) and non-recurring cyclical (irregular) components that was not included in the original BFAST technique and it was included in the methodology of this study. BFTSC was created to give a mutual image of all the required time series components. The subsequently forecasting technique was determined and forecast is made.
Adams-Oliver Syndrome (OSA)
Authors: Ourrai Abdelhakim. , Azitoune Sanae. , Hassani Amal. , Agadr Aomar. , Abilkassem Rachid. 
Published: December 2023

Introduction: Adams-Oliver's syndrome (SAO) is a rare genetic condition characterized by the association of lumb anomalies and Aplasia cutis congenita in vertex, often accompanied by underlying ossification defect and vascular lesions. The objective through this new observation is to describe the clinical, radiological, therapeutic and evolutionary elements according to what was described up to there in the literature.
Observation: Female newborn child, stemming from a pregnancy followed with normal obstetric ultrasounds. He presents a scalp agenesis, underlying cranial bone aplasia and toes hypoplasia with syndactyly. The association of these two major criteria allowed making the diagnosis of SAO. Moreover, she presents disjointed and large sagittal suture with left parietal bone borders hypoplasia. The notion of periventricular bleeding. The rest of the balance sheet deformation, namely the abdominal ultrasound and echocardiography was without anomalies. The newborn was sent in neurosurgery for restorative treatment, which will be planned at the age of 3 months.
Discussion and Conclusion: This observation illustrates sporadic and not complicated SAO. The absence of complete gene mapping in SAO and therefore of any genetic counseling, prenatal morphological ultrasound, is making important in evolutionary terms of subsequent pregnancies.
Systematic Review of Carbapenem Resistant Gram-negative Infective Endocarditis, Treatment Options and Outcomes
Authors: Walczak A.  
Published: December 2023

Background: Gram negative infective endocarditis is rare and usually associated with intravenous drug use or significant healthcare exposure and prosthetic cardiac valves or devices. Carbapenem resistance is a growing concern worldwide with limited drug options for these infections especially serious high inoculum infections such as endocarditis.
Methods: A systematic review examining treatment options and outcomes was conducted with identification of 12 cases in the literature.
Results: Pseudomonas aeruginosa was the most common organism with left sided valvular involvement being most common. 18 different antibiotic regimens were used with surgery occurring in 5 cases (42%). In hospital mortality was 33% which increased at 6 months post episode. Increased age (p= 0.056) and CCI (p=0.006) appeared to be associated with death. Microbiological cure was more common in patients who received combination therapy with 2 active agents (75% successful) and combination therapy including an active beta-lactam agent (100% successful) but these did not meet statistical significance.
Conclusions: Recommendations for management of this rare condition based on this systematic review and other available evidence are summarised in this review. Management should generally involve multidisciplinary teams, combination therapy with at least 2 active agents including a beta-lactam agent where possible with consideration of surgery in all cases. Evidence is however limited with need for ongoing publication of cases and further research to guide therapy in the future.
The Role Played by Students’ Government in Managing Discipline in Public Secondary Schools
Authors: Gervas Sosthenes 
Published: December 2023

The study aimed at assessing the role played by students’ government in managing discipline in public secondary schools in Bukoba municipality, Kagera, Tanzania. This study adopted a mixed methods research approach supported with a convergent parallel research design. The participants were 120 (i.e., 15 HBs, 15 HGs, and 90 SLs). Data collection methods were questionnaires and interviews. Findings have indicated that, prevalent student’s misbehaviours are the use of abusive words among students and to teachers and stealing of others’ property; others are students’ absenteeism in school without excuse, lateness to school, failure to complete assignments and exercises provided by the teacher, noisemaking in class, fighting and examination malpractices. In regard to the involvement of students’ leaders in the formulation of rules and regulations, findings have established that, students’ leaders are not given an opportunity to provide their views on the already prepared school rules and regulations, on co-curricular activities (sports, games or cultural trips), to formulate rules concerning the design of school uniforms or in the preparation of school rules and regulations. On the issue of the challenges encountered by students’ leaders, findings show that, students’ leaders are challenged with irregular meetings which interfere with academic calendars, lack of feedback from teachers, failure by the students to take instructions from their government. Other challenges failure to complete class assignments and exercises on time, lack of cooperation from students and lack of enough time to engage in private studies. On the strategies employed by students’ leaders in alleviating indiscipline cases in public secondary schools, students’ responses have shown that, students’ leaders inflict corporal punishments to their deviant fellow students or verbal warnings or guidance and counselling groups. Based on the findings above, suggestions and recommendations are provided.
Bibliometric Analysis of Publications on “Hazards and Health Effects Associated with Welding” From 2010 – 2023
Authors: Ayodeji-Fapohunda G. N.  , Ugwoha E.  , Nwaichi E. O.  
Published: December 2023

An overview of the hazards and health effects associated with exposure to welding fumes is provided in this paper through adaptations from various sources. The growing concerns around welding and its attendant health effects are valid as welding fumes are inherently hazardous and are composed of particulate matter from condensed metals and obnoxious gases such as Ozone which have been implicated in the aetiology and pathophysiology of many diseases including cancer. Information currently available from various published study works is described in the review. In accordance with the bibliometric analysis, "The United States" ranks as the most prolific contributor, with a large collection of works from active organizations such as the National Institute of Occupational Safety and Health (NIOSH). Additionally, author cooperation has increased recently and is more common in groups. Three hot themes in welding-related hazards and health effects—"human," "age," and "occupational exposure"—were identified across all keyword analyses. Furthermore, oxidative stress, occupational diseases, risk management, cohort studies, and air pollutants in welding were identified as new themes by the keywords analysis. To the extent that we are aware, this study is the first explicit bibliometric approach to visualize the research field of health and hazard impacts related to welding. It is helpful for locating hotspots in active research now and for speculating on prospective future research areas.
Effectiveness of Integrated Management on Fusarium-Nematode wilt Complex Disease of Banana cv. Ney Poovan (AB): Insights from a Field Study
Authors: Murali, R.  , Priyadarshan Ashok , Nagaraja, H.  , Narayanaswamy, H.  
Published: December 2023

Banana (Musa spp.) belongs to the family Musaceae is the most important fruit crop in the world, serving as a staple food and source of income in many developing countries. There are several diseases recorded on Banana causing serious losses. Wilt complex disease caused by Fusarium oxysporum f. sp. cubense and Radopholus similis is considered as a serious threat Banana cultivation. A field experiment was conducted in a randomised complete block design with susceptible Banana variety Nay Poovan (AB) to manage the fungal-nematode wilt complex using treatments of bioagents, organic amendments and chemicals in individual as well as in integrated approach. The experiment results revealed that, Carbendazim (262.73 cm) treated plants had good plant height and it was on par with combined treatments. Among combination treatments, T11 (Neem cake + FYM +T. viride + + P. fluorescens +P. lilacinus + Carbofuran + stem injection of Carbendazim at 5,7,9 months) gave maximum plant height (118.00, 195.27 and 262.60 cm). The least plant height was recorded in control 89.60 cm, 140.00 cm and 188.00 cm at 90, 180 days after planting and at harvest respectively. The final population of R. similis in soil was lowest in T11 (Neem cake + FYM, T. viride+P. fluorescens+P. lilacinus + Carbofuran + stem injection of Carbendazim at 5,7,9 months) (6.33 /200 cc soil), followed by T6 (T. viride + P. lilacinus) (26.33 /200 cc soil), whereas control treatment has maximum (1382.00 /200 cc soil). Regarding wilt incidence, the plants treated with Neem cake + FYM, T. viride+P. fluorescens+P. lilacinus + Carbofuran + stem injection of Carbendazimat 5, 7, 9 months (T11) recorded less incidence (11.12%) as compared to the maximum wilt incidence of 88.89 per cent in control treatment. The next best treatment was T10 (Carbendazim 17.67 %). Individual application the maximum number of hands per bunch, bunch weight and total yield per hectare was recorded in T10(Carbendazim) 13.80, 12.75 kg and 45.75 t/ha), T2(P. Fluorescens) (9.67, 9.73 kg and 36.05 t/ha) and least was recorded in T9 (Carbofuron) (8.75, 8.25 kg and 32.50 t/ha) compare to control. Among the combined treatments, the maximum number of hands per bunch (19.75), bunch weight (16.80 kg) and total yield per hectare (26.33 t/ha) was recorded in treatment T11 (Neem cake + FYM, T. viride+P. fluorescens+P. lilacinus + Carbofuran + stem injection of Carbendazim at 5, 7, 9 months). The economic analysis revealed that, the T11 had recorded a maximum benefit cost ratio of 4.26 followed by T10 – Carbendazim (3.96) percent incidence and the least benefit cost ratio was recorded by control (1.23).
Predictivity of Human Telomerase Reverse Transcriptase (h-TERT) in Oral Squamous Cell Carcinoma: Immunohistochemical Study
Authors: Mosaad Eman , Elhendawy Heba Ahmed , Mahfouz Mena , El-sissy Nadia Abbas Ibrahim 
Published: December 2023

Aims: Determine the potential role of h-TERT as a prognostic marker for oral squamous cell carcinoma by evaluating its immunohistochemical expression in different OSCC histologic grades in comparison with normal oral mucosa.
Study Design: A retrospective study.
Place and Duration: Oncology Center, Mansoura University, and Oral Pathology Department, Faculty of Dentistry, Mansoura University. The worked sample selected from the years (2015-2019).
Methodology: Our study was accomplished on 30 OSCC cases and a control group of normal oral mucosa. Histopathologic grading of OSCCs was made using the WHO grade and Anneroth`s grading systems. Immunohistochemical expression of h-TERT was assessed in relation to different clinicopathological parameters. The data was analyzed using Pearson`s chi-square test to compare the differences between groups. Spearman's correlation co-efficiency test was used to test the association between different variables. A P value ≤ 0.05 was considered to be statistically significant.
Results: A significant increased h-TERT expression was recorded from normal to OSCC groups (P=0.000). Additionally, elevated h-TERT expression was significantly correlated with the higher carcinoma histologic grade (P =0.025). There were high statistically significant differences in h-TERT expression concerning the parameters; Anneroth pattern of invasion (P= 0.049), depth of invasion (DOI, P=0.024), and lymphoplasmacytic infiltration (LPI, P=0.009). There were no statistically significant differences in h-TERT immunoexpression considering the clinical parameters; patient age, gender, anatomical sites, clinical shape of lesion, T, N, M, and TNM stages (Chi-square test, P values were > 0.05).
Conclusions: Increased h-TERT immunoexpression from normal to OSCC groups suggests its involvement in malignant transformation. Additionally, the significant differential expression of h-TERT among different OSCC histologic grades signaling its valuable use as a biomarker for assessing the cellular malignant progression of oral carcinomas, but unreliable as a clinical tumor progression marker. Moreover, the significant correlation of h-TERT expression with LPI, DOI and pattern of invasion indicating its possible reliable role in tumor host relation during multistage carcinogenesis.