bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference in tissue temperature change between two cryoballoons
Authors: Hayashi Takahiro , Hamada Kohei , Iwasaki Kiyotaka , Takada Jumpei , Murakami Masato , Saito Shigeru 
Published: December 2023

BackgroundCryoballoon ablation, especially Arctic Front Advance Pro (AFA-Pro) (Medtronic, Minneapolis, Minnesota, USA), has been widely recognised as a standard approach to atrial fibrillation (AF). Recently, Boston Scientific has released a novel cryoballoon system (POLARx). Despite comparable acute clinical outcomes of these two cryoballoons, the recent study reported a higher complication rate, especially for phrenic nerve palsy, with POLARx. However, their impact on biological tissue remains unclear.ObjectiveThe purpose of our study is to evaluate temperature change of biological tissue during cryoablation of each cryoballoon using a porcine experimental model.MethodA tissue-based pulmonary vein model was constructed from porcine myocardial tissue and placed on a stage designed to simulate pulmonary vein anatomy and venous flow. Controlled cryoablations of AFA-Pro and POLARx were performed in this model to evaluate the tissue temperature. A temperature sensor was set behind the muscle and cryoballoon ablation was performed after confirming the occlusion of pulmonary vein with cryoballoon.ResultsThe mean tissue nadir temperature during cryoablation with AFA-Pro was −41.5°C±4.9°C, while the mean tissue nadir temperature during cryoablation with POLARx was −58.4°C±5.9°C (p<0.001). The mean balloon nadir temperature during cryoablation with AFA-Pro was −54.6°C±2.6°C and the mean balloon nadir temperature during cryoablation with POLARx was −64.7°C±3.8°C (p<0.001).ConclusionPOLARx could freeze the biological tissue more strongly than AFA-Pro.
To Quiesce or Senesce, That Is the Question for Dedifferentiated Liposarcoma
Authors: Weiss Mia C. , Eulo Vanessa , Van Tine Brian A. 
Published: December 2023

SummaryDedifferentiated liposarcoma (DDLPS) has an appealing therapeutic target due to its CDK4 amplification on chromosome 12q. The understanding of geroconversion from quiescent cells to senescent cells defines a patient's response to CDK4 inhibitors. This new observation will inform not only the ongoing phase III clinical trial of abemaciclib, but all future clinical trials in DDLPS.See related article by Gleason et al., p. 703
Electrophysiological Characteristics and Ablation Outcomes in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Shen Lishui , Liu Shangyu , Hu Feng , Zhang Zhenhao , Li Jiakun , Lai Zihao , Zheng Lihui , Yao Yan 
Published: December 2023

Background
Catheter ablation of premature ventricular contractions (PVCs) that trigger polymorphic ventricular tachycardia (PVT) or ventricular fibrillation has been reported as a novel therapy to reduce the syncope events in patients with catecholaminergic PVT, whereas the long‐term ablation outcome and its value in improving exercise‐induced ventricular arrhythmias remain unclear.

Methods and Results

Fourteen consecutive selected patients with catecholaminergic PVT (mean±SD age, 16±6 years; 43% male patients) treated with maximum β‐blockers with no possibility of adding flecainide were prospectively enrolled for catheter ablation. The primary end point was syncope recurrence, and the secondary end point was the reduction of the ventricular arrhythmia score during exercise testing. Twenty‐six PVT/ventricular fibrillation–triggering PVCs were identified for ablation. The trigger beats arose from the left ventricle in 50% of the cases and from both ventricles in 36% of the cases. Purkinje potentials were observed at 27% of the targets. After a mean follow‐up of 49 months after ablation, 8 (57%) patients were free from syncope recurrence. Ablation of trigger beat significantly reduced the syncope frequency (mean±SD, 4.3±1.6 to 0.5±0.8 events per year;
P
<0.001) and improved the ventricular arrhythmia scores at the 3‐month (5 [range, 3–6] to 1.5 [range, 0–5];
P
=0.002) and 12‐month (5 [range, 3–6] to 2 [range, 0–5];
P
=0.014) follow‐ups. The induction of nontriggering PVCs postablation was closely associated with syncope recurrence (hazard ratio, 6.8 [95% CI, 1.3–35.5];
P
=0.026).

Conclusions
Catheter ablation of PVT/ventricular fibrillation–triggering PVCs in patients with catecholaminergic PVT who cannot receive flecainide treatment seems to be a safe and feasible adjunctive treatment that may reduce the syncope burden and improve exercise‐related ventricular arrhythmias. Induction of nontriggering PVCs after ablation is associated with a higher risk of syncope recurrence.
A Newly Identified Treatise on the Tables of Marseilles (Twelfth Century) and Its Non-Ptolemaic Planetary Theory
Authors: Nothaft C. Philipp E. 
Published: December 2023

Abstract
Two Latin manuscripts in Oxford and Florence preserve diverging recensions of a previously unnoticed astronomical treatise beginning Infra signiferi poli regionem (Oxford recension) or Circulorum alius est sub quo (Florence recension). It can be shown that this anonymous text was originally intended to accompany the Tables of Marseilles in Raymond of Marseilles’s twelfth-century Liber cursuum planetarum (ca. 1141). While the core tables for planetary longitudes in this set were founded on Ptolemy’s kinematic models, as known from the Almagest, this new source frequently deviates from the Ptolemaic norm, for instance by explicitly rejecting an epicyclic explanation of planetary stations and retrogradations. In place of the latter, it argues in favour of a heliodynamic theory inspired by Roman sources such as Pliny, which underwent certain developments in the works of twelfth-century Latin writers such as William of Conches. Rather than being wholly exceptional, these features are indicative of a degree of disconnect between planetary theory and computational practice in twelfth-century Latin astronomy, which is also detectable in other sources from this period.
Visual Narratives of Boxer-era China: Two German Photo Albums of the Early 1900s
Authors: Klein Thoralf 
Published: December 2023

Abstract
In this article, I examine two ‘semi-public’ German photo albums composed in the immediate aftermath of the international military intervention in China in 1900–01 known as the Boxer War. One was compiled by two members of the German East Asian Expeditionary Corps, Dr Wang and Lieutenant Freiherr von Meerscheidt-Hüllessem, the other by the incoming German minister to Beijing, Alfred von Mumm. I will begin by developing a narrative theory of the photo album. I will use this to demonstrate how the two albums visually (re-)construct a multifaceted journey through space and time in which political and military themes blend with a cultural gaze on China’s architecture as well as its people. The albums are thus situated at the intersection between imperialist intervention, cultural ethnography and modern (foreign) tourism in China. And they reflect various power differentials: not just the one between imperialist agents and victims but equally that between ethnographers and the people they study, as well as the one that characterises modern tourism.
Conversion of mycotoxin-contaminated maize by black soldier fly larvae into feed and fertilizer
Authors: Gold M. , Niermans K. , Jooste F. , Stanford L. , Uwamahoro F. , Wanja M. , Veldkamp T. , Sanderson A. , Dos Santos Nunes V. , Mathys A. , van der Fels-Klerx H.J. , Hoek-van den Hil E.F. , Nishimwe K. 
Published: December 2023

Abstract
Globally, large amounts of various crops such as cereals, oilseeds, nuts and spices are contaminated with mycotoxins during pre-harvest, postharvest handling, processing and/or storage. Mycotoxin contamination results into economic and health issues, and valorisation options of contaminated crops are urgently needed. The aim of this research was to evaluate whether quality feed and fertilizer can be safely produced from naturally mycotoxin contaminated crops using black soldier fly larvae (BSFL, Hermetia illucens L.) under realistic field conditions in East Africa. Naturally mycotoxin contaminated maize (corn; Zea mays L.) was used as a model due its prevalence as food and feed and utilized by BSFL together with local agri-food by-products at a research facility in Rwanda. To assess the influence of the initial maize mycotoxin contamination and maize inclusion, larval diets with three mycotoxin contamination levels and two maize inclusion levels were tested. BSFL were tolerant against the high mycotoxin concentrations (e.g. 99.4 μg aflatoxin B1 kg dry mass-1) as the presence of mycotoxins in the substrate did not affect BSFL mass at harvest. Product safety was assessed by quantifying the presence of 38 common and emerging mycotoxins and metabolites in the maize, substrates and BSFL products (e.g. larvae and frass). The results show that it is possible to produce feed and fertilizer with BSFL considered safe within the European Union and East African legal limits with maize contaminated with mycotoxins typical for East Africa. Thereby, this research works towards the safe recycling of nutrients from mycotoxin contaminated maize within the food system in East Africa and beyond.
Precedents in Peacemaking
Authors: Ehrhardt Andrew 
Published: December 2023

Abstract
This article examines the peace settlements of 1815, 1919, and 1945 with an eye towards drawing out certain insights for current conflicts, specifically the Russo-Ukrainian War. Among the points covered in this article are the position and capability of military forces, the alignments and agreements which take place before and after the main peace negotiations, the assumptions around how long a settlement might last, the influence of existing social and intellectual currents which surround the statesmen and women negotiating peace, and the importance of individual personalities in arriving at a lasting and stable peace. How long the war between Russia and Ukraine will last is uncertain, but it is more likely than not that policymakers in Moscow and Kiev, as well as their counterparts in capitals across Europe and beyond, will consider eventual negotiations. This article provides ideas and approaches from some of the most notable precedents in the 19th and 20th centuries, as a way of stimulating thinking about a future peace settlement.
Postprocessing of Ensemble Weather Forecasts Using Permutation-Invariant Neural Networks
Authors: Höhlein Kevin , Schulz Benedikt , Westermann Rüdiger , Lerch Sebastian 
Published: December 2023

Abstract
Statistical postprocessing is used to translate ensembles of raw numerical weather forecasts into reliable probabilistic forecast distributions. In this study, we examine the use of permutation-invariant neural networks for this task. In contrast to previous approaches, which often operate on ensemble summary statistics and dismiss details of the ensemble distribution, we propose networks that treat forecast ensembles as a set of unordered member forecasts and learn link functions that are by design invariant to permutations of the member ordering. We evaluate the quality of the obtained forecast distributions in terms of calibration and sharpness and compare the models against classical and neural network–based benchmark methods. In case studies addressing the postprocessing of surface temperature and wind gust forecasts, we demonstrate state-of-the-art prediction quality. To deepen the understanding of the learned inference process, we further propose a permutation-based importance analysis for ensemble-valued predictors, which highlights specific aspects of the ensemble forecast that are considered important by the trained postprocessing models. Our results suggest that most of the relevant information is contained in a few ensemble-internal degrees of freedom, which may impact the design of future ensemble forecasting and postprocessing systems.
Supercell Thunderstorms in Complex Topography—How Mountain Valleys with Lakes Can Increase Occurrence Frequency
Authors: Feldmann Monika , Rotunno Richard , Germann Urs , Berne Alexis 
Published: December 2023

Abstract
This study investigates the effects of lakes in mountainous terrain on the evolution of supercell thunderstorms. With a newly developed radar-based, mesocyclone-detection algorithm, a recent study has characterized the occurrence and evolution of supercell thunderstorms in the Swiss Alpine region. That study highlights the influence of orography on both storm intensity and occurrence frequency. To disentangle the different influential factors, an idealized modeling framework is established here using the mesoscale model CM1. The modeling scenarios are based on a high-CAPE environment with unidirectional shear, where a warm bubble serves to initiate the convection. Mimicking the environment of the southern Prealps in central Europe, scenarios with a high mountain ridge, valleys, and lakes are explored. The effect on the supercells of the slopes, high-altitude terrain, and moisture sources emphasizes the highly localized nature of terrain effects, leading to a heterogeneous intensity life cycle with transitory enhancement and weakening of the supercell. The dynamic and thermodynamic impact of mountain valleys with lakes increases the range of atmospheric conditions that supports supercellular development through horizontal vorticity production, increased storm relative helicity, and higher moisture content. This influence results in a systematic location dependence of the frequency, intensity, and lifetime of supercells, as also found in observations.
Rural Melanoma Patients Have Less Surgery and Higher Melanoma-Specific Mortality
Authors: Hernandez Alexandra E. , Benck Kelley N. , Huerta Carlos T. , Ogobuiro Ifeanyichukwu , De La Cruz Ku Gabriel , Möller Mecker G. 
Published: December 2023

Background Melanoma causes most skin cancer–related deaths, and disparities in mortality persist. Rural communities, compared to urban, face higher levels of poverty and more barriers to care, leading to higher stage at presentation and shorter survival in melanoma. To further evaluate these disparities, we sought to assess the association between rurality and melanoma cause-specific mortality and receipt of recommended surgery in a national cohort. Methods Patients with primary non-ocular, cutaneous melanoma from the SEER database, 2000-2017, were included. Outcomes included melanoma-specific survival and receipt of recommended surgery. Rurality was based on Rural-Urban Continuum Codes. Variables included age, sex, race, ethnicity, income, and stage. Multivariate regression models assessed the effect of rurality on survival and receipt of recommended surgery. Results 103,606 patients diagnosed with non-ocular cutaneous primary melanoma met criteria during this period. 93.3% ( n = 96620) were in urban areas and 6.7% ( n = 6986) were in rural areas. On multivariate regression controlling for age, sex, race, ethnicity, and stage patients living in a rural area were less likely to receive recommended surgery (aOR .52, 95% CI: .29-.90, P = .02) and had increased hazard of melanoma-specific mortality (aHR 1.19, 95% CI: 1.02-1.40, P = .03) even after additionally controlling for surgery receipt. Conclusion Using a large national cohort, our study found that rural patients were less likely to receive recommended surgery and had shorter melanoma cause-specific survival. Our findings highlight the importance of access to cancer care in rural areas and how this ultimately effects survival for these patients.
Fragmentation of Care After Geriatric Trauma: A Nationwide Analysis of outcomes and Predictors
Authors: Gogna Shekhar , Zangbar Bardiya , Rafieezadeh Aryan , Hanna Kamil , Shnaydman Ilya , Con Jorge , Bronstein Matthew , Klein Joshua , Prabhakaran Kartik 
Published: December 2023

The health care system for the elderly is fragmented, that is worsened when readmission occurs to different hospitals. There is limited investigation into the impact of fragmentation on geriatric trauma patient outcomes. The aim of this study was to compare the outcomes following readmissions after geriatric trauma. The Nationwide Readmissions Database (2016-2017) was queried for elderly trauma patients (aged ≥65 years) readmitted due to any cause. Patients were divided into 2 groups according to readmission: index vs non-index hospital. Outcomes were 30 and 180-day complications, mortality, and the number of subsequent readmissions. Multivariable logistic regression was performed to analyze the independent predictors of fragmentation of care. A total of 36,176 trauma patients were readmitted, of which 3856 elderly patients (aged ≥65 years) were readmitted: index hospital (3420; 89%) vs non-index hospital (436; 11%). Following 1:2 propensity matching, elderly with non-index hospital readmission had higher rates of death and MI within 180 days ( P = .01 and .02, respectively). They had statistically higher 30 and 180-day pneumonia ( P < .01), CHF ( P < .01), arrhythmias ( P < .01), MI ( P < .01), sepsis ( P < .01), and UTI ( P < .01). On multivariable binary logistic regression analysis, pneumonia (OR 1.70, P = .03), congestive heart failure (CHF) (OR 1.80, P = .03), female gender (OR .72, P = .04), and severe Head and Neck trauma (AIS≥3) (OR 1.50, P < .01) on index admission were independent predictors of fragmentation of care. While the increase in time to readmission (OR 1.01, P < .01) was also associated independently with non-index hospital admission. Fragmented care after geriatric trauma could be associated with higher mortality and complications.
A Bayesian Analysis of a Cognitive-Behavioral Therapy Intervention for High-Risk People on Probation
Authors: Han SeungHoon , Hyatt Jordan M. , Barnes Geoffrey C. , Sherman Lawrence W. 
Published: December 2023

This analysis employs a Bayesian framework to estimate the impact of a Cognitive-Behavioral Therapy (CBT) intervention on the recidivism of high-risk people under community supervision. The study relies on the reanalysis of experimental datal using a Bayesian logistic regression model. In doing so, new estimates of programmatic impact were produced using weakly informative Cauchy priors and the Hamiltonian Monte Carlo method. The Bayesian analysis indicated that CBT reduced the prevalence of new charges for total, non-violent, property, and drug crimes. However, the effectiveness of the CBT program varied meaningfully depending on the participant's age. The probability of the successful reduction of drug offenses was high only for younger individuals (<26 years old), while there was an impact on property offenses only for older individuals (>26 years old). In general, the probability of the successful reduction of new charges was higher for the older group of people on probation. Generally, this study demonstrates that Bayesian analysis can complement the more commonplace Null Hypothesis Significance Test (NHST) analysis in experimental research by providing practically useful probability information. Additionally, the specific findings of the reestimation support the principles of risk-needs responsivity and risk-stratified community supervision and align with related findings, though important differences emerge. In this case, the Bayesian estimations suggest that the effect of the intervention may vary for different types of crime depending on the age of the participants. This is informative for the development of evidence-based correctional policy and effective community supervision programming.
Long-term venovenous extracorporeal membrane oxygenation support for acute respiratory distress syndrome after COVID-19
Authors: Wang Wei , Feng Ying , Li Zhenzhen , Lin Xin , Song Ruixia , Chen Gang , Ma Ruchao , Ma Guiqing 
Published: December 2023

Introduction Acute respiratory syndrome (ARDS) following coronavirus 2 (SARS-CoV-2) infection is a serious complication often causing irreversible lung injury associated with high mortality. Extracorporeal membrane oxygenation (ECMO) may be initiated in severe cases. We present a case of ARDS following SARS-CoV-2 infection with prolonged duration ECMO (1045 hours, 44 days) without exchanging circuit throughout the whole duration without technical complication. Case report A 71-year-old man of acute respiratory failure secondary to SARS-CoV-2 infection was initiated on venovenous ECMO (VV-ECMO). There was no technical complication without exchanging circuit throughout the whole prolonged ECMO duration (1045 hours, 44 days). Despite a great effort to improve his lung mechanics and gas exchange, there was continued clinical and physiological deterioration unfortunately. Following family discussion and with input from the multidisciplinary team (MDT) including palliative care specialists, there was recognition of deterioration despite optimal respiratory support. Shortly thereafter planned withdrawal occurred, and the patient passed away with his family at his bedside. Discussion This case study illustrates that it may be considered to use long term ECMO as a bridge to recovery or lung transplantation of ARDS patient after SARS-CoV-2 infection with severe lung injury. Benefits from proper long-term ECMO management,it is possible of sparing to exchange circuit throughout the whole prolonged duration without technical complication. Conclusion This case indicates the feasibility of using of a long term VV-ECMO as a bridge to recovery or lung transplantation of ARDS patient after secondary to coronavirus 2 (SARS-CoV-2) infection with severe lung injury without circuit exchange. The optimal duration of VV-ECMO support and optimal diagnostic modalities for critical assessment of native lung recovery or irretrievable severe lung injury still require further investigation.
Applied patient-level palliative care interventions designed to meet the needs of sexual and gender minorities: A scoping review and qualitative content analysis of how to support sexual and gender minorities at end of life
Authors: Robinson Lilian , Matamoros Cam 
Published: December 2023

Background: Sexual and gender minorities experience considerable health disparities across the life span. End of life presents unique challenges for this population, further exacerbating existing disparities. Aim: We aimed to identify applied patient-level palliative care interventions for sexual and gender minorities and describe how said interventions met the needs of these populations at end of life. Design: We conducted a scoping review in keeping with the updated Arksey and O’Malley Framework. All included reports were analyzed qualitatively to describe the intervention and summarize thematically how it met the needs of sexual and gender minorities at end of life. Data sources: We conducted searches in MEDLINE, EMBASE, PsychInfo, and CINAHL from 1946 to June 10, 2023. Reports were eligible for inclusion if they described a palliative care intervention delivered to sexual and gender minorities, and if the palliative care intervention responded to at least one specific need of the sexual and gender minority population(s) in question. Results: We included and summarized 27 reports. We identified three overarching themes describing how palliative care interventions responded to the needs of sexual and gender minorities at end of life. Conclusions: This review responds to a need to improve palliative care delivery for sexual and gender minorities. Recommendations derived from these interventions, including how to center and advocate for sexual and gender minorities at end of life, can be applied by any interdisciplinary palliative care provider.
Builders Behaving Badly: The Rise and Fall of the Chief Workman Paneb (i) at Deir el-Medîna
Authors: Sweeney Deborah 
Published: December 2023

This article offers a new analysis of the period during the late 19th Dynasty when Paneb (i) was chief workman of the right-hand side of the crew, arguing that the political upheavals of these years are closely connected to Paneb’s rise to power and fall from grace. Building on Benedict Davies’ prosopographical work on the Deir el-Medîna workmen1 and Mark Collier’s dating of the administrative ostraca of this period,2 this article sheds new light on the appointments made during this period, and on other features of Paneb’s administration. [Formula: see text]