bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of 18F-FDG PET/TC for the characterization of adrenal lesions in a heterogeneous population
Authors: Romanisio Martina , Daffara Tommaso , Pitino Rosa , Ferrero Alice , Pizzolitto Francesca , Zavattaro Marco , Biello Federica , Gennari Alessandra , Volpe Alessandro , Sacchetti Gian Mauro , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia , Caputo Marina 
Published: November 2023

Abstract
Purpose
Data regarding 18F-FDG PET for the characterization of adrenal lesions are limited; to evaluate the performance of the tumour-to-liver maximum standardized uptake values (SUVratio) > 1.5 to predict malignancy.
Patients and methods
: Retrospective analysis of adrenal lesions undergoing 18F-FDG-PET/CT (2013–2022). Gold standard for benignity was: i) histology; ii) stability or minimal diameter increase (< 20%/< 5 mm) on 12-months follow-up. The performance of SUVratio > 1.5 and the optimal SUVratio in our population was calculated by ROC curves.
Results
42 lesions (diameter 36.1 ± 20.3 mm, 6 bilateral) out of 177 patients underwent 18FDG-PET/CT and were included (17 M/19 F, age 61.2 ± 11.7 years). According to gold standards, 29 lesions were benign, 11 malignant [8 metastases (2 bilateral) and 1 adrenocortical carcinoma (ACC)] and 2 pheochromocytomas. The diagnosis of adrenal masses with a SUVratio > 1.5 was: 10 metastases, 1 ACC, 2 non-functioning adenomas, 1 hyperplasia and 1 pheochromocytoma. The SUVratio agreed with the diagnosis in 90.5% of patients; in the 4 discordant cases (SUVratio > 1.5 and non-malignant lesion) the diagnosis was: 2 non-functioning adenomas, 1 hyperplasia, 1 pheochromocytoma. The SUVratio cut-off of 1.5 showed 100% Sn, 87% Sp, 73% PPV, and 100% NPV. The SUVratio cut-off calculated in our population was 1.55 (Sn 100%, Sp 73.7%, AUC 0.868), with similar values excluding pheochromocytomas and metastases (SUVratio cut-off 1.49, Sn 100%, Sp 96.3%, AUC 0.988).
Conclusion
18F-FDG PET/CT could help in decision making process avoiding unnecessary surgery. The SUVratio cut-off of 1.5 has a good performance in a heterogenous population.
Revealing the Development of Agriculture Wastewater Treatment: A Bibliometric Analysis of Global Publications from 1971 to 2022 using Scopus Database
Authors: Hartini Hajjar , Juahir Hafizan , Hanis Nur , Zulaikha Nur , Nasir Nurfarahana Mohd , Kurniawan Setyo Budi , Zakaria Nurulhuda , Nor Siti Mariam Muhammad 
Published: November 2023

Abstract
This bibliometric study examines scholarly research on agriculture wastewater treatment using Scopus data from 1971 to 2022. The analysis explores publication trends, leading countries, prolific authors, and keyword co-occurrences. By employing various procedures to collect and refine data, a total of 1,706 research articles were retrieved. The findings indicate a steady growth in research on wastewater treatment since the 1970s, with a significant surge in publications in recent decades. Notably, there has been a considerable increase in research related to wastewater agriculture treatment, focusing on topics such as wastewater treatment technologies, agriculture reuse, and environmental impacts. The analysis also highlights influential authors, institutions, and countries driving research in this field, along with the most cited publications and journals. Additionally, the study identifies research gaps and suggests future research directions in wastewater treatment. From an economic standpoint, this analysis offers insights into the economic value of wastewater treatment research, including its potential to enhance resource efficiency, reduce environmental costs, and foster sustainable agricultural practices. Moreover, it underscores the importance of research policy in shaping the direction and impact of wastewater treatment studies. Overall, this bibliometric analysis provides valuable insights into the landscape of wastewater treatment research, its evolution over the past five decades, and its economic and policy implications.
Novel Plasma Protein Biomarkers: A Time-Dependent predictive model for Alzheimer's Disease
Authors: Zhuang Tianchi , Yang Yingqi , Ren Haili , Gao Chang , Chen Shen , Shen Jiemiao , Ji Minghui , Cui Yan 
Published: November 2023

Abstract
Background
The accurate prediction of Alzheimer's disease (AD) is crucial for the efficient management of its progression. The objective of this research is to construct a new risk predictive model utilizing novel plasma protein biomarkers for predicting AD incidence in the future and analyze their potential biological correlation with AD incidence.
Methods
A cohort of 440 participants aged 60 years and older from the Alzheimer's Disease Neuroimaging Initiative (ADNI) longitudinal cohort was utilized. The baseline plasma proteomics data was employed to conduct Cox regression, LASSO regression, and cross-validation to identify plasma protein signatures predictive of AD risk. Subsequently, a multivariable Cox proportional hazards model based on these signatures was constructed. The performance of the risk prediction model was evaluated using time-dependent receiver operating characteristic (t-ROC) curves and Kaplan-Meier curves. Additionally, we analyzed the correlations between protein signature expression in plasma and predicted AD risk, the time of AD onset, the expression of protein signatures in cerebrospinal fluid (CSF), the expression of CSF biomarkers, and APOE ε4 genotypes.
Results
We identified seven protein signatures (APOE, CGA, CRP, CCL26, CCL20, NRCAM, and PYY) that independently predicted AD incidence in the future. The risk prediction model demonstrated area under the ROC curve (AUC) values of 0.77, 0.76, and 0.77 for predicting AD incidence at 4, 6, and 8 years, respectively. Furthermore, the model remained stable in the range of the 3rd to the 12th year (ROC ≥ 0.75). The low-risk group, as defined by the model, exhibited a significantly later AD onset compared to the high-risk group (P < 0.0001). Moreover, all protein signatures exhibited significant correlations with AD risk (P < 0.001) and the time of AD onset (P < 0.01). There was no strong correlation between the protein expression levels in plasma and CSF, as well as AD CSF biomarkers. APOE, CGA, and CRP exhibited significantly lower expression levels in APOE ε4 positive individuals (P < 0.05).
Conclusion
Our research has successfully identified protein signatures in plasma as potential risk biomarkers that can independently predict AD incidence in the future. Notably, this risk prediction model has demonstrated commendable predictive performance and stability over time. These findings underscore the promising utility of plasma protein signatures in dynamically predicting the risk of Alzheimer's disease, thereby facilitating early screening and intervention strategies.
Expanding the genotype-phenotype correlations and mutational spectrum in inherited retinal diseases: novel and recurrent mutations
Authors: Sahin Ibrahim , Erdem Haktan Bagis , Bahsi Taha , Saat Hanife 
Published: November 2023

Abstract
Background
Inherited retinal diseases (IRD) represent a prominent etiology of visual impairment on a global scale. The lack of a clear definition of the etiology and genotypic spectrum of IRD is attributed to the significant genetic variability seen. Additionally, there is a scarcity of available data about the correlations between genotypes and phenotypes in this context. This study aimed to clarify the range of mutations and the associations between genotypes and phenotypes in IRD.
Methods
This cohort consists of 223 patients who have been diagnosed with a range of retinal illnesses, such as Retinitis Pigmentosa (RP), Stargardt (STGD)/STGD-like disease, Usher syndrome, and Leber Congenital Amaurosis (LCA). The validation of each mutation and its pathogenicity was conducted by bioinformatics analysis, Sanger sequencing-based co-segregation testing, and computational assessment. The link between genotype and phenotype was analyzed in all patients who possessed mutations as described in the recommendations established by the American College of Medical Genetics.
Results
A total of 223 cases, comprising Turkish and Syrian families, were examined, revealing the presence of 78 distinct mutations in the IRD gene. Among these mutations, 58 were identified as unique, indicating that they had not been previously reported. A total of 119 mutations were identified to be likely pathogenic, while 104 mutations were classified as pathogenic. The study identified patterns of heredity, namely autosomal recessive, dominant, and X-linked inheritance.
Conclusions
The findings of this study broaden the clinical and molecular aspects of IRD and further enhance our understanding of its complex nature. The discovery of previously unknown relationships between genetic variations and observable traits, as well as the wide range of genetic variants associated with IRD, significantly contributes to our existing understanding of the diverse phenotypic and genotypic characteristics of IRD. This new information will prove invaluable in facilitating accurate clinical diagnoses as well as personalized therapeutic interventions for individuals affected by IRD.
Seismic Spectrum Feature Extraction Method Combining Allan Variance, VMD, and PSD: - A Case Study of the 2022 Mw 2.6 Microseismic Event in Huairou, Beijing
Authors: Liu Xu , Wang Jian , Liu Fei , Hancock Craig 
Published: November 2023

Abstract
Spectrum feature extraction plays a crucial role in identifying earthquake events and calculating seismic parameters. However, the identification standards of effective modal components in variational mode decomposition (VMD) are incomplete, leading to imprecise spectrum feature extraction. To address this issue, we propose a novel seismic spectrum feature extraction method that combines Allan variance, VMD, and power spectral density (PSD). First, VMD is applied to filter noise components from triaxial accelerometer observations and add effective signals. Second, PSD is utilized to extract three groups of seismic frequencies (tri-axial accelerometers). Finally, the Allan method is introduced to identify the group of accelerometer observations with the highest reliability as the vibration frequency caused by the seismic excitation. We validate the effectiveness of our method by analyzing a Mw 2.6 microseismic event that occurred in Huairou, Beijing in 2022. Our analysis demonstrates that triaxial accelerometers can effectively detect such events with a magnitude of 2.6. Additionally, our proposed method accurately extracts seismic spectrum features. Specifically, the seismic excitation vibration frequencies at four seismic monitoring stations were found to be 26.95 Hz, 12.89 Hz, 12.89 Hz, and 12.5 Hz. These findings highlight the potential of our approach for identifying and characterizing earthquake events, which has important implications for earthquake monitoring and hazard assessment.
Seasonal variation of trends and homogeneity of extreme forest fire danger index (FFDI) value
Authors: Hossain Iqbal , Khastagir Anirban , Gato-Trinidad Shirley , Anwar A. H. M. Faisal , Rasel HM 
Published: November 2023

Abstract
The traditional approach of potential fire danger is determined using the forest fire danger index (FFDI). Seasonal variability of the influential variables has significant impacts on the magnitude of extreme FFDI values. In this study, the severity of FFDI is determined using different statistical approaches following various hypotheses. The application of statistical analysis requires the data to be obtained from the same population distribution. The main objective of this research was to investigate the seasonal variation of homogeneity, trend, and change points of extreme FFDI. McArthur Forest Fire Danger index technique was employed in estimating the daily forest fire danger index for 15 stations located in Tasmania, Australia. Seasonal maximum FFDI values were extracted from the estimated daily FFDI values. Seasonal variation of trend analysis was performed after performing a homogeneity test. Non-parametric Mann- Kendall trend test was applied to investigate the trend of the seasonal extreme data sets. The scale of the trend was investigated employing the commonly used Sen’s slope. The results of the analysis reveal that there are temporal and spatial variations of the increasing FFDI values across Tasmania due to climate change. An extreme data series that accepts one statistical hypothesis in one theory may reject the same hypothesis in another theory. Seasonal variation in the future trend of FFDI will help to improve the management of natural resources and sustainable planning in the region. The adoption of appropriate construction strategies in extreme fire regions can be determined from this study.
Toxicity and repellent activity of a carlina oxide nanoemulsion toward the South American tomato pinworm, Tuta absoluta
Authors: Tortorici Simona , Zeni Valeria , Perinelli Diego Romano , Ferrati Marta , Spinozzi Eleonora , Maggi Filippo , Benelli Giovanni , Rizzo Roberto 
Published: November 2023

Abstract
Plant essential oil (EO)-based insecticides represent a promising tool for IPM, though their formulation is limited by poor physio-chemical properties. EO encapsulation into stable formulations, like nano emulsions (NEs), could boost EO efficacy and stability. Carlina acaulis roots contain an EO recently studied for its excellent insecticidal activities, and chiefly composed by carlina oxide (>97%). Herein, we developed two carlina oxide NEs (0.25% and 0.5% w/w) through ultrasounds exposure and characterized them by dynamic light scattering. The NE insecticidal and repellent activities were investigated against T. absoluta eggs and larvae, and adults, respectively. 0.25% and 0.5% NEs showed a monomodal size distribution with a Z-average size of 113.87±1.32 nm and 127.27±0.47 nm, respectively. The polydispersity indexes measured at 0.15±0.01 and 0.16±0.01 indicate a low grade of polydispersity. The 0.25% NE showed significant contact toxicity on T. absoluta eggs, with a maximum egg hatching inhibition of 85.7% 11 days post-treatment. The highest larvicidal effect was observed in translaminar toxicity tests, with complete mortality after 24 h. The NE did not achieve significant oviposition deterrence. Overall, the tested NE showed promising effectiveness as ovicide and larvicide on T. absoluta, highlighting the need of further research shedding light on its modes of action, as well as to evaluate lethal and sublethal effects on tomato biological control agents and pollinators.
Total Flavonoids of Litchi Seed alleviates schistosomiasis liver fibrosis by suppressing hepatic stellate cells activation
Authors: Zhan Tingzheng , Cheng Qiuchen , Wang Jilong , Lv Jiahui , Mo Jingquan , Qiu Ran , Li Caiqi , Xiao Suyu , Luo Liuchun , Tang Lili , He Shanshan , Tang Zeli , Li Qing 
Published: November 2023

Abstract
Background Infection with Schistosoma japonicum (S. japonicum) can lead to liver fibrosis. The activation of hepatic stellate cells (HSCs) is a crucial phase in the development of liver fibrosis, and inhibiting their activation can alleviate this progression. Total Flavonoids of Litchi Seed (TFL) is a naturally extracted drug, and modern pharmacological studies have shown its anti-fibrotic and liver-protective effects. However, the role of TFL in schistosomiasis liver fibrosis still unclear. This study investigates the functions of TFL on liver fibrosis caused by S. japonicum infection and explores its potential mechanisms.
Methods: S. japonicum-induced murine models were generated by abdominal infection with 20 cercariae. The mice were divided into an infection group and a treatment group. The treatment group were treated with TFL (300 and 450 mg/kg). Inflammatory-related cytokines were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Hematoxylin and Eosin (H&E) and Masson's trichrome staining were used to observe pathological changes in the liver. Immunohistochemistry was employed to detect the expressions of α-Smooth Muscle Actin (α-SMA), Collagen I, and Collagen III in the liver tissues. For the cell experiments, a model of HSCs activation induced by Transforming Growth Factor-β1 (TGF-β1) was established, and the effects of TFL on the activation of HSCs were examined using qPCR.
Results TFL significantly reduced the levels of Interleukin-1β (IL-1β), Tumor Necrosis Factor-α (TNF-α), and Interleukin-6 (IL-6) in the serum of S. japonicum infected mice. TFL reduced the liver and spleen index of mice and markedly improved the pathological changes in liver tissues induced by Sj, decreasing the expression of α-SMA, Collagen I protein and Collagen III protein in liver tissues. In vitro studies indicated that TFL apparently inhibited the activation of HCSs induced by TGF-β1 and reduced the levels of α-SMA.
Conclusion TFL could alleviate granulomatous lesions and improve liver fibrosis caused by S. japonicum by inhibiting the activation of HSCs.
An Earth-sized exoplanet ripe for emission spectroscopy with JWST in orbit around a nearby ultracool dwarf star
Authors: Gillon Michaël , Pedersen Peter , Rackham Benjamin , Dransfield Georgina , Ducrot Elsa , Barkaoui Khalid , Burdanov Artem , Schroffenegger Urs , Chew Yilen Gomez Maqueo , Lederer Susan , Alonso Roi , Burgasser Adam , Howell Steve , Narita Norio , de Wit Julien , Demory B , Queloz Didier , Triaud Amaury , Delrez L , Jehin Emmanuel , Hooton M , Garcia Lionel , Munoz Claudia Jano , Murray Catriona , Pozuelos Francisco , Sebastian Daniel , Timmermans Mathilde , Thompson Samantha , Zuniga-Fernandez Sebastian , Aceituno Jesús , Aganze Christian , Amado Pedro , Benkhaldoun Zouhair , Bolmont Émeline , Clark Catherine , Davoudi Fatemeh , de Leon J , Ikoma Masahiro , Ikuta K , Isogai Keisuke , Fukuda Izuru , Fukui Akihiko , Gerasimov Roman , Ghachoui Mourad , Hayashi Yuya , Hu Renyu , Kagetani T , Kawai Yugo , Kawauchi Kiyoe , Koll Daniel , Livingston John , Lyu Xintong , Mori Mayuko , Murgas Felipe , Palle Enric , Rebolo Rafael , Selsis Franck , Sota Alfredo , Stassun Keivan , Tamura Motohide , Theissen Christopher , Turbet Martin , Grootel Valerie Van , Varas Roberto , Watanabe Noriharu 
Published: November 2023

Abstract

The JWST space telescope has the potential to measure the emission spectrum of a highly irradiated exoplanet as small as the Earth, especially if it transits a very nearby and cold star similar in size to Jupiter. Such ‘ultracool dwarf stars’ are frequent in the solar neighborhood, but their planetary population remain extremely poorly studied. Indeed, only one transiting planetary system had been discovered around an ultracool dwarf star so far, TRAPPIST-1, and none of its seven planets is irradiated enough to make spectroscopic characterization by occultation emission spectroscopy possible with JWST. Here we present the discovery by the SPECULOOS project of an Earth-sized planet on a 17 hr orbit around an M6.5-type dwarf star 16.8 parsecs away. Thanks to its large irradiation (∼16 times the Earth’s), the infrared brightness, and Jupiter-like size of its host star, emission spectroscopy is possible with JWST, enabling the study of the planet’s atmospheric composition and/or surface mineralogy
Klein-gordon Oscillator in Dynamical Noncommutative Space
Authors: Haouam Ilyas 
Published: November 2023

Abstract
This paper aims to investigate the two-dimensional Klein-Gordon oscillator system in a dynamical noncommutative (DNC) space. We address the deformed system using the time-independent perturbation theory, where the energy eigenvalues and eigenvectors are obtained in relativistic and nonrelativistic regimes, also the effects of the dynamical and non-dynamical noncommutative settings are successfully examined. Then some numerical results are given and used to extensively study the conduct of the system under the various considerations. Note that in the DNC space, the space-space commutation relations and noncommutative parameter are position-dependent. The ﬁrst-order corrections to the eigensystem are found, then, it is shown that the energy shift depends on the DNC parameter τ . Moreover, using the accuracy of energy measurement, we put an upper bound on the parameter τ . Knowing that, with a set of two-dimensional Bopp-shift transformation, we link the noncommutative problem to the standard commutative one.
Reconsiderações habermasianas para o conceito de ética da BNCC
Authors: Fernandes Araújo Fábio Rodrigo 
Published: November 2023

Na história educacional, em particular nos PCNS (1997), a ética adquire o status de tema transversal para uma educação básica de qualidade, quando são inseridos os conceitos de justiça, dialogo, afetos e emoções, reciprocidade, diálogo e racionalidade enquanto conteúdos comuns para as práticas pedagógicas e para os conhecimentos específicos das disciplinas. Na BNCC, a referência exata a esse conceito se faz nas competências gerais 6, 7, 9 e 10, como também, na menção do termo formação que está presente na introdução dos tópicos que propõe bases para o pensar educativo das ciências humanas e sociais. Desta forma, a intenção é propor, pela filosofia de Jürgen Habermas, uma nova abordagem conceitual sobre ética presente na BNCC. A pesquisa se constitui por uma análise bibliográfica e interpretativa da Base Nacional Comum Curricular (BNCC), das obras de Jürgen Habermas e de artigos referentes à educação e agir comunicativo. Logo, no campo educacional, o conceito de ética, na BNCC, pode ter uma estruturação com indicações racionais e comunicativas, conteúdos possibilitados pelo filosofar brasileiro, e mobilização de conhecimentos a partir de princípios e lógicas de ordem geográfica e simbólica. Esta ordem tem como base procedimentos, conceitos e entendimentos intersubjetivos, dimensões que são conduzidas através de aprendizagens construídas pelo discurso, tanto em sua forma multidimensional como concordante entre os atores sociais.
Competência informacional com vistas à mulher em situação de violência
Authors: Neri Georginei Souza , Mota Francisca Rosaline Leite 
Published: November 2023

A violência contra a mulher é uma realidade mundial estabelecida nas desigualdades de gênero e perpetuada por discursos culturais e sociais. O acesso e uso de informações precisas e atualizadas sobre diferentes formas de violência são fundamentais para romper o ciclo de agressão e da falta de conhecimento sobre direitos e leis de proteção. Nesta perspectiva, é mister entender o comportamento informacional e fomentar a Competência Informacional das mulheres vítimas da violência de gênero. O presente artigo se propõe a tecer considerações sobre as deficiências sociais, políticas e operacionais existentes na esfera de amparo e proteção às mulheres vítimas de violência (s). Como resultado, propõe a construção de um modelo de rede pautado na intersecção mulher-informação-órgãos de apoio e proteção contra à(s) violência(s), fundamentada nas competências em informação de modo concomitante.
The Role of TRIM Proteins in Vascular Disease
Authors: Chen Xinxin , Chen Xiaolong 
Published: November 2023

Abstract:
There are more than 80 different tripartite motifs (TRIM) proteins within the E3 ubiquitin
ligase subfamily, including proteins that regulate intracellular signaling, apoptosis, autophagy, proliferation,
inflammation, and immunity through the ubiquitination of target proteins. Studies conducted
in recent years have unraveled the importance of TRIM proteins in the pathophysiology of vascular
diseases. In this review, we describe the effects of TRIM proteins on vascular endothelial cells,
smooth muscle cells, heart, and lungs. In particular, we discuss the potential mechanisms by which
TRIMs regulate diseases and shed light on the potential therapeutic applications of TRIMs.