bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Sinonasal Low-Grade Nonintestinal Adenocarcinoma That Was Difficult to Diagnose Preoperatively
Authors: Mizoguchi Yoshie , Tanaka Sunao , Kikuchi Shigeru 
Published: December 2023

AbstractWe report a case of sinonasal low-grade, nonintestinal adenocarcinoma (LG non-ITAC). The patient, a 56-year-old woman, was referred to our university hospital for a left nasal tumor with nasal obstruction, epistaxis, and nasal discharge. Nasal endoscopy revealed a nasal polypoid tumor with a smooth margin occupying the left nasal cavity. The sinonasal tumor was diagnosed as an exophytic papilloma by histopathology. Sinonasal contrast computed tomography (CT) confirmed homogeneous opacification of the left frontal, maxillary, and ethmoidal sinuses. There was no evidence of a potential bone defect. T2-weighted magnetic resonance imaging (MRI) showed a relatively uniform high signal intensity area in the left maxillary and frontal sinuses. An area of high signal intensity was also found in a part of the left ethmoid sinus. Left transnasal endoscopic ethmoidectomy was performed under general anesthesia. The tumor in the nasal cavity was prone to bleeding. We defined the site of tumor attachment as the suprabullar cell. The anterior ethmoidal artery was exposed, and the tumor was carefully dissected and removed. Based on the findings of these radiological and histological examinations, the sinonasal tumor was diagnosed as a LG non-ITAC. Sinonasal non-ITAC is an adenocarcinoma without the histopathological characteristics of salivary or intestinal-type adenocarcinoma. Non-ITAC is additionally classified into the high-grade and LG types. LG non-ITAC is very uncommon. Thus far, there is only one published report in the literature on the clinical and therapeutic characteristics of LG non-ITAC in Japan. Non-ITAC has a good prognosis, with a low risk of metastasis. Therefore, it is imperative to suspect and distinguish non-ITAC from other sinonasal tumors with similar symptoms preoperatively.
The Matthew Effect: Prevalence of Doctor and Physician Parents among Ophthalmology Applicants
Authors: Khair Diana , Blanchard Cody C. , Wang Kevin K. , Moore Daniel B. 
Published: December 2023

Abstract
Objective This article determines the prevalence of physician parents among ophthalmology residency applications.
Design Retrospective, single-center cohort study.
Subjects All applicants to the University of Kentucky Ophthalmology Residency between 2018 and 2023.
Methods Residency applications were reviewed, with data collection including applicant gender, self-identified Under-Represented in Medicine (URiM) status, United States Medical Licensing Examination (USMLE) Step 1 score, USMLE Step 2 score, and whether the application identified a doctor or physician as a parent. Doctor was defined as a profession requiring a doctorate degree, and similarly, physician as a profession requiring a medical degree.
Results A total of 2,057 applications were reviewed, representing 54% of all match participants during the study period. Fourteen percent (296) of applications indicated a parent was a doctor and 12% (253) a parent was a physician. There were no differences between gender, URiM, USMLE Step 1, and Step 2 scores between applicants indicating a doctor or physician as a parent and those that did not (p all > 0.4 and Cohen's d all < 0.02). Of the type of doctors, 85% (253) were physicians, 6% (17) optometrists, 6% (17) Doctors of Philosophy, 3% (8) dentists, 1% (1) pharmacist, and 1% (1) veterinarian. Eighty-six percent (217) of applications with a physician parent provided the type of physician, with ophthalmologist the most common (93, 43%). Ninety-eight percent (249) of applications with a physician parent provided the gender of the parent, with father (168, 68%) more common than mother (42, 17%) or both parents (39, 16%).
Conclusion Physician parents are substantially overrepresented in ophthalmology residency applicants. This raises concerns regarding diversity and inclusion efforts for recruitment in medicine.
Culturomics in Unraveling the Upper Female Reproductive Tract Microbiota
Authors: Vanstokstraeten Robin , Demuyser Thomas , Piérard Denis , Wybo Ingrid , Blockeel Christophe , Mackens Shari 
Published: December 2023

AbstractIn recent years, the study of the human microbiome has surged, shedding light on potential connections between microbiome composition and various diseases. One specific area of intense interest within this research is the female reproductive tract, as it holds the potential to influence the process of embryo implantation. Advanced sequencing technologies have delivered unprecedented insights into the microbial communities, also known as microbiota, residing in the female reproductive tract. However, their efficacy encounters significant challenges when analyzing low-biomass microbiota, such as those present in the endometrium. These molecular techniques are susceptible to contamination from laboratory reagents and extraction kits, leading to sequencing bias that can significantly alter the perceived taxonomy of a sample. Consequently, investigating the microbiota of the upper female reproductive tract necessitates the exploration of alternative methods. In this context, the current review delves into the application of culturomics in unraveling the upper female reproductive tract microbiota. While culturomics holds value in research, its transition to routine clinical practice appears remote, at least in the foreseeable future.
What is the tertiary norm of belief?
Authors: Dykstra Jorren 
Published: December 2023

Abstract
Timothy Williamson (in ‘Justifications, excuses, and sceptical scenarios’) distinguishes three kinds of norm for belief, which he calls ‘primary’, ‘secondary’ and ‘tertiary’. He argues that a belief is justified if it satisfies the primary norm and excused if it satisfies only the tertiary norm. The argument turns on cases of intuitively unjustified belief in which the tertiary norm is satisfied, on Williamson’s rough-and-ready statement of that norm. I argue that, once we state the tertiary norm more carefully, it is clear that it is not satisfied in these cases. So we need some other reason to think that the tertiary norm is not justifying.
Multivariate base rates of potentially problematic scores on the NIH Toolbox Emotion Battery
Authors: Ingram Eric O , Karr Justin E 
Published: December 2023

Abstract

Objective
To examine the normal frequency of obtaining one or more scores considered potentially problematic based on normative comparisons when completing the NIH Toolbox Emotion Battery (NIHTB-EB).

Method
Participants (N = 753; ages 18–85, 62.4% women, 66.4% non-Hispanic White) from the NIHTB norming study completed 17 scales of emotional functioning fitting into three subdomains (i.e., Negative Affect, Psychological Well-being, Social Satisfaction). Scores were considered potentially problematic if they were 1 SD above/below the mean, depending on the orientation of the scale, and cutoffs for 1.5 and 2 SD were also included for reference. Multivariate base rates quantified the rate at which participants obtained one or more potentially problematic scale or subdomain scores.

Results
The portion of participants obtaining one or more potentially problematic scores on the NIHTB-EB scales and subdomains was 61.2 and 23.2%, respectively. Participants who were younger (i.e., 18–49) or had less education had higher rates of potentially problematic scores within specific subdomains. There were no significant differences by sex or race/ethnicity.

Conclusions
Elevated scores on the NIHTB-EB were common in the normative sample and related to education/age. The multivariate base rates provided indicate obtaining one or more potentially problematic scores on the NIHTB-EB is broadly normal among adults, which may guard against overinterpreting a single score as clinically significant. These base rates should be considered in the context of other assessment findings, such as interviews, medical history or informant reports, to ensure that true emotional problems are not dismissed, and normal variation in emotional functioning is not pathologized.
MSIpixel: a fully automated pipeline for compound annotation and quantitation in mass spectrometry imaging experiments
Authors: Morosi Lavinia , Miotto Matteo , Timo Sara , Carloni Sara , Bruno Eleonora , Meroni Marina , Menna Elisabetta , Lodato Simona , Rescigno Maria , Martano Giuseppe 
Published: December 2023

Abstract
Mass spectrometry imaging (MSI) is commonly used to map the spatial distribution of small molecules within complex biological matrices. One of the major challenges in imaging MS-based spatial metabolomics is molecular identification and metabolite annotation, to address this limitation, annotation is often complemented with parallel bulk LC-MS2-based metabolomics to confirm and validate identifications. Here we applied MSI method, utilizing data-dependent acquisition, to visualize and identify unknown molecules in a single instrument run. To reach this aim we developed MSIpixel, a fully automated pipeline for compound annotation and quantitation in MSI experiments. It overcomes challenges in molecular identification, and improving reliability and comprehensiveness in MSI-based spatial metabolomics.
Synopsis of Osmunda (royal ferns; Osmundaceae): towards reconciliation of genetic and biogeographic patterns with morphologic variation
Authors: Lehnert Marcus , Monjau Tilo , Rosche Christoph 
Published: December 2023

Abstract
We present an overview of the morphology, biogeography, and ecology of the fern genus Osmunda (i.e. without previously included taxa of Claytosmunda, Osmundastrum, and Plenasium), with a focus on the American O. spectabilis Willd. and Old World O. regalis L. While genetic data supports the separation of these taxa, commonly used morphologic characters to distinguish between O. regalis and O. spectabilis (maximum frond size; pinnae sessile vs. stalked; pinnules opposite vs. alternate; general pinnule proportions) are not infallible. We recorded morphometric differences among and between O. regalis and O. spectabilis and correlated these with spatio-environmental gradients. Our work provides an updated taxonomic overview with full synonymy and diagnostic key of Osmunda. We preliminarily recognize six informal subtaxa in O. regalis (‘regalis’, ‘abyssinica’, ‘huegeliana’, ‘longifolia’, ‘transvaalensis’, ‘obtusifolia’) and three in O. spectabilis (‘spectabilis’, ‘palustris’, ‘piresii’) that separate in a morphological traits-based principal component analysis. The morphotaxa appeared geographically structured and their distribution showed significant correlations with elevation, mean annual precipitation, annual mean temperature, and temperature seasonality. The taxonomic rank and validity of the proposed subtaxa has to be tested through a large-scale sampling, e.g. with comparative cp/nr genomic and cytogenetic analyses. Such future analyses may help to ascertain whether the observed morphologic peculiarities are conditioned solely by abiotic factors (which would allow addressing them as forms) or are manifested in the genome.
fMRI evidence of movement familiarization effects on recognition memory in professional dancers
Authors: Wang Yingying , Zhao Qi , Ji Qingchun , Jin Xinhong , Zhou Chenglin , Lu Yingzhi 
Published: December 2023

Abstract
Dual-process theories propose that recognition memory involves recollection and familiarity; however, the impact of motor expertise on memory recognition, especially the interplay between familiarity and recollection, is relatively unexplored. This functional magnetic resonance imaging study used videos of a dancer performing International Latin Dance Styles as stimuli to investigate memory recognition in professional dancers and matched controls. Participants observed and then reported whether they recognized dance actions, recording the level of confidence in their recollections, whereas blood-oxygen-level-dependent signals measured encoding and recognition processes. Professional dancers showed higher accuracy and hit rates for high-confidence judgments, whereas matched controls exhibited the opposite trend for low-confidence judgments. The right putamen and precentral gyrus showed group-based moderation effects, especially for high-confidence (vs. low-confidence) action recognition in professional dancers. During action recognition, the right superior temporal gyrus and insula showed increased activation for accurate recognition and high-confidence retrieval, particularly in matched controls. These findings highlighting enhanced action memory of professional dancers—evident in their heightened recognition confidence—not only supports the dual-processing model but also underscores the crucial role of expertise-driven familiarity in bolstering successful recollection. Additionally, they emphasize the involvement of the action observation network and frontal brain regions in facilitating detailed encoding linked to intention processing.
Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways
Authors: Velagapudi Srividya , Wang Dongdong , Poti Francesco , Feuerborn Renata , Robert Jerome , Schlumpf Eveline , Yalcinkaya Mustafa , Panteloglou Grigorios , Potapenko Anton , Simoni Manuela , Rohrer Lucia , Nofer Jerzy-Roch , von Eckardstein Arnold 
Published: December 2023

Abstract

Aims
The entry of lipoproteins from blood into the arterial wall is a rate-limiting step in atherosclerosis. It is controversial whether this happens by filtration or regulated transendothelial transport.
Because sphingosine-1-phosphate (S1P) preserves the endothelial barrier, we investigated in vivo and in vitro, whether S1P and its cognate S1P-receptor 3 (S1P3) regulate the transendothelial transport of lipoproteins.

Methods and results
Compared to apoE-haploinsufficient mice (CTRL), apoE-haploinsufficient mice with additional endothelium-specific knock-in of S1P3 (S1P3-iECKI) showed decreased transport of LDL and Evan’s Blue but increased transport of HDL from blood into the peritoneal cave. After 30 weeks of high-fat diet feeding, S1P3-iECKI mice had lower levels of non-HDL-cholesterol and less atherosclerosis than CTRL mice. In vitro stimulation with an S1P3 agonist increased the transport of 125I-HDL but decreased the transport of 125I-LDL through human aortic endothelial cells (HAECs). Conversely, inhibition or knock-down of S1P3 decreased the transport of 125I-HDL but increased the transport of 125I-LDL. Silencing of SCARB1 encoding scavenger receptor B1 (SR-BI) abrogated the stimulation of 125I-HDL transport by the S1P3 agonist. The transendothelial transport of 125I-LDL was decreased by silencing of SCARB1 or ACVLR1 encoding activin-like kinase 1 but not by interference with LDLR. None of the three knock-downs prevented the stimulatory effect of S1P3 inhibition on transendothelial 125I-LDL transport.

Conclusion
S1P3 regulates the transendothelial transport of HDL and LDL oppositely by SR-BI-dependent and SR-BI-independent mechanisms, respectively. This divergence supports a contention that lipoproteins pass the endothelial barrier by specifically regulated mechanisms rather than passive filtration.
Churros: a Docker-based pipeline for large-scale epigenomic analysis
Authors: Wang Jiankang , Nakato Ryuichiro 
Published: December 2023

Abstract
The epigenome, which reflects the modifications on chromatin or DNA sequences, provides crucial insight into gene expression regulation and cellular activity. With the continuous accumulation of epigenomic datasets such as chromatin immunoprecipitation followed by sequencing (ChIP-seq) data, there is a great demand for a streamlined pipeline to consistently process them, especially for large-dataset comparisons involving hundreds of samples. Here, we present Churros, an end-to-end epigenomic analysis pipeline that is environmentally independent and optimized for handling large-scale data. We successfully demonstrated the effectiveness of Churros by analyzing large-scale ChIP-seq datasets with the hg38 or Telomere-to-Telomere (T2T) human reference genome. We found that applying T2T to the typical analysis workflow has important impacts on read mapping, quality checks, and peak calling. We also introduced a useful feature to study context-specific epigenomic landscapes. Churros will contribute a comprehensive and unified resource for analyzing large-scale epigenomic data.
The Impact of Dietary Interventions on the Microbiota in Inflammatory Bowel Disease: A Systematic Review
Authors: Nieva Cheenie , Pryor Jennifer , Williams Georgina M , Hoedt Emily C , Burns Grace L , Eslick Guy D , Talley Nicholas J , Duncanson Kerith , Keely Simon 
Published: December 2023

Abstract

Background and Aims
Diet plays an integral role in the modulation of the intestinal environment, with the potential to be modified for management of individuals with inflammatory bowel disease [IBD]. It has been hypothesised that poor ‘Western-style’ dietary patterns select for a microbiota that drives IBD inflammation and, that through dietary intervention, a healthy microbiota may be restored. This study aimed to systematically review the literature and assess current available evidence regarding the influence of diet on the intestinal microbiota composition in IBD patients, and how this may affect disease activity.

Methods
MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library were searched from January 2013 to June 2023, to identify studies investigating diet and microbiota in IBD.

Results
Thirteen primary studies met the inclusion criteria and were selected for narrative synthesis. Reported associations between diet and microbiota in IBD were conflicting due to the considerable degree of heterogeneity between studies. Nine intervention studies trialled specific diets and did not demonstrate significant shifts in the diversity and abundance of intestinal microbial communities or improvement in disease outcomes. The remaining four cross-sectional studies did not find a specific microbial signature associated with habitual dietary patterns in IBD patients.

Conclusions
Diet modulates the gut microbiota, and this may have implications for IBD; however, the body of evidence does not currently support clear dietary patterns or food constituents that are associated with a specific microbiota profile or disease marker in IBD patients. Further research is required with a focus on robust and consistent methodology to achieve improved identification of associations.
Arthropod predator community associated with soybean gall midge,Resseliella maxima(Diptera: Cecidomyiidae), in Minnesotan soybean fields
Authors: Melotto Gloria , Potter Bruce D , Lindsey Amelia R I , Koch Robert L 
Published: December 2023

AbstractThe soybean gall midge, Resseliella maxima Gagné (Diptera: Cecidomyiidae), is a pest that injures soybeans in the Midwest United States. Little is known about the natural enemies of R. maxima or the potential for biological control. Therefore, we performed a 2-yr survey in Minnesota to examine the predator community associated with R. maxima infestations. We found that Orius insidiosus (Say) (Heteroptera: Anthocoridae) and Pterostichus melanarius (Illiger) (Coleoptera: Carabidae) were the most common foliar- and ground-foraging predators, respectively. Some of the commonly encountered predator species were tested in laboratory predation experiments. Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae) and O. insidiosus represented the foliar-foraging predators tested, and H. axyridis consumed significantly more R. maxima larvae than O. insidiosus. Among the ground-foraging predators, 4 carabids were tested. Poecilus lucublandus (Say) (Coleoptera: Carabidae) and Pt. melanarius consumed significantly more R. maxima larvae than Poecilus chalcites (Say) (Coleoptera: Carabidae) and Bembidion quadrimaculatum oppositum (Say) (Coleoptera: Carabidae). We conclude that Pt. melanarius should receive further attention as a potential biological control agent of R. maxima, due to its high abundance in the soybean fields in this study, temporal overlap with the pest, and high propensity to feed on the pest.
Cryoballoon ablation of peri-mitral atrial flutter refractory to radiofrequency ablation: a case report
Authors: Takahashi Masao , Kujiraoka Hirofumi , Arai Tomoyuki , Hojo Rintaro , Fukamizu Seiji 
Published: December 2023

Abstract

Background
The radiofrequency catheter ablation of peri-mitral atrial flutter is occasionally difficult, mostly due to epicardial or intramural conduction on the mitral isthmus (MI). However, cryoballoon ablation (CBA) of peri-mitral atrial flutter refractory to radiofrequency ablation has not been reported.

Case summary
We report a case of a 66-year-old male patient who experienced a recurrence of atypical atrial flutter and underwent the sixth catheter ablation. The activation and entrainment maps showed that this atypical atrial flutter (AFL) was peri-mitral AFL via pathways other than endocardial conduction in the MI. Previous radiofrequency catheter ablation attempts on the MI line, including endocardial, coronary sinus, and epicardial ablations, failed to achieve a bidirectional block of the MI. In this case, we selected CBA for the MI area and successfully achieved a bidirectional block of the MI.

Discussion
Although using CBA in the MI is off-label, it could be safely implemented using CARTOUNIVU™. We attributed the success of the bidirectional block of the MI in this case to the crimping of the northern hemisphere of the CBA to the mitral isthmus area, which resulted in the formation of a broad, uniform, and deep ablation lesion site.
England’s Mercantilism: Trading Companies, Employment and the Politics of Trade in Global History, 1688–1704
Authors: Bromley Hugo 
Published: December 2023

Abstract
A close study of how the status of trading companies changed after 1688 demonstrates that mercantilist decision-making was a more widespread, more national process than is commonly assumed. English manufacturers and merchants looked to the state to support them in an increasingly global economy. Parliament’s position as the key decision-making institution helped turn London into an ‘open archive’ of pamphlets, petitions and correspondence that became the basis for mercantilist policy. In this chaotic debate between private interests, domestic employment was considered the primary objective of wider English participation in the global economy, and those English producers who could claim to be employing others were valued particularly highly. The role of the wider English nation in shaping the global impact of the state suggests the need for a fuller exploration of the role of mercantilism in early modern global history.
William Byrd’s Come, woeful Orpheus in context: motion as visual and musical affect
Authors: Bank Katie 
Published: December 2023

Abstract
Looking at William Byrd’s consort song Come, woeful Orpheus (1611) and the Orpheus overmantel at Haddon Hall (Derbyshire), this article imagines how music and visual culture provided reciprocal somatic and symbolic cues within the domestic sphere. Using Richard Haydock’s Tracte containing the artes of curious paintinge (1598), it considers how the Orpheus trope, cogitated and embodied through visual and musical media, could be used to produced ‘fellow feeling’ and affect through ‘motion’. ‘Motion’ was not only fundamental to early modern theories of affective communication but was thought to provide the spark of life that aided interpersonal connection.
This research explores the shared language between the theoretical and affective aspects of music and art in early modern England, stemming from classical sources on decorum and persuasive oration, to provide a more nuanced understanding of contemporary experiences of recreational music-making. I argue that the embodied and visual contributions of the performers are crucial to understanding Byrd’s song, as early modern approaches to motion and affect relied upon the body and voice, and were best communicated through sight and sound.