bluuebunny/crossref_metadata_2025_split huggingface dataset:
Il fascino discreto della violenza (nel Mezzogiorno in guerra) / Periferie controrivoluzionarie. La resistenza borbonica al nazionalismo liberale in Italia e in Spagna: una lettura comparata / Legittimismo e controrivoluzione nella prima guerra italiana
Authors:   Redazione
Published: October 2023

L'intervento inserisce comparativamente il brigantaggio nel Mezzogiorno d'Italia nel quadro della mobilitazione controrivoluzionaria del XIX secolo nell'area mediterranea, mostrando che il tratto unificante di queste esperienze è il patriottismo monarchico che rappresenta un'autentica cultura politica diffusa fra le masse popolari abituate all'uso delle armi e quindi capaci di sostenere il conflitto civile in nome dell'assolutismo contro il nuovo potere rivoluzionario.Il contributo si sofferma su uno dei molteplici aspetti che emergono dal volume, ovvero le forme di legittimismo e controrivoluzione che si svilupparono nel decennio dell'unificazione italiana. A partire dall'analisi di Pinto sulla dimensione politica del brigantaggio, l'autrice si concentra, in primo luogo, sul rapporto tra questo fenomeno e le insorgenze più risalenti, interrogandosi sulla possibilità di individuare una "tradizione controrivoluzionaria" nella storia del Mezzogiorno. In secondo luogo, l'autrice passa ad analizzare il borbonismo nel quadro della controrivoluzione ottocentesca europea, sottolineando i limiti di tale progetto politico. Proprio la debolezza del progetto politico borbonico e, ancor più, del suo nesso con il brigantaggio, favorirono la delegittimazione di quest'ultimo come avversario politico da parte dell'ultimo soggetto evocato dal titolo, gli italiani. L'ampio ricorso a misure eccezionali da parte dello stato italiano, in fase di costruzione, fecero sì che esso assumesse immediatamente il volto dell'iper-stato per ragioni di sicurezza, in cui le esigenze statali incontrarono istanze della società meridionale.
Tsunami Evacuation Accessibiliyu Simulation Using Network Analysis Tools In Tsunami Prone Areas Of Tanggamus District
Authors: Muhaemin Moh 
Published: October 2023

Geological activity in the Sunda Strait received attention through the tsunami that occurred at the end of 2018 and the tectonic earthquake in the Sunda Strait subduction zone with Magnitude 6.9 on August 2, 2019. These conditions raise concerns about the threat of earthquake and tsunami disasters in the surrounding area. Tanggamus Regency, which is located within a fairly close radius to the Sunda Strait, has a very wide tsunami-prone lowland, especially in the area around the tip of Teluk Semangka. Based on these conditions, this research generally aims to map evacuation service areas, map evacuation times, and analyze effective evacuation models. To answer these challenges, this research was conducted following several methodological stages. It started with defining the study area using spatial analysis, digitizing the road network and interlinking it with the Network Analysys tool on the ArcGIS platform. Based on the observation, it was found that the most at-risk areas are those that have the farthest distance from the Temporary Evacuation Site (TES) location when traveled without a vehicle. Each region has a TES location that can be reached using the available roadways. There are 3 sub-districts that have a travel time of more than 30 minutes to reach the TES, namely, Semaka sub-district, Wonosobo sub-district and Kota Agung Barat sub-district. It is expected that the results of this study can be one of the considerations in tsunami disaster mitigation efforts in Tanggamus Regency.
Nationalism In Realizing The Goals Of The National Pillars: Challenges, Creative And Innovative Ideas That Youth Should Have
Authors: Agustian Rio Armanda 
Published: October 2023

The importance of understanding the four pillars of nationalism in the life of the nation and state for today's young generation, especially nationalism, is so that youth have the values of national insight and patriotism in themselves so that they have a sense of responsibility in providing the best for their country. To fulfill this, the youth must have creative and innovative ideas and ideas in building the nation and state. The four pillars of nationalism consisting of Pancasila, Undang-Undang Dasar Tahun 1945, Bhinneka Tunggal Ika and Negara Kesatuan Republik Indonesia have the value of moral principles to achieve the life of an independent, sovereign, just and prosperous Indonesian nation as stated in the goals of the Nation and state in the UUD Negara Republik Indonesia tahun 1945. This is reflected that these 4 pillars have important purposes and meanings and are useful for current and future generations.
It should be realized by today's youth that the younger generation must be required to face all the challenges that exist today, namely globalization which is very extraordinary in affecting the sense of nationalism of youth. We can also see the many law violations that occur committed by youth as a result of the lack of actualizing the values of the 4 pillars of nationalism in family life, society and the nation and state.
As for other efforts that can be made to foster a sense of nationalism, namely by making a work with the theme of love for the country, heroism, and so on that is national in nature so that in the process of making the work the younger generation will be reminded of the struggles of the nation's heroes before and thus a sense of nationalism in themselves will be embedded and grow in their souls. Related to the above, there are actually many positive activities that can be carried out by young people to build their country so that the sense of nationalism can be maintained.
Система управління безпекою польотів державної авіації України: сучасний стан та перспективи
Authors: Гончаренко Є. В. , Радько О. В. , Мартинюк О. Р. , Блискун О. Є. 
Published: October 2023

У статті розглядаються проблемні питання функціонування системи управління безпекою польотів державної авіації України. Метою статті є визначення сучасного стану та перспектив розвитку цієї системи на основі аналізу досвіду країн – членів НАТО, рекомендацій і практик міжнародних організацій цивільної авіації та з урахуванням завдань із забезпечення національної безпеки та оборони держави і захисту населення країни, що стоять перед державною авіацією України. Аналіз проведено з використанням методу DOTMLPFI.
Установлено, що такі базові складові системи, як доктринальна, організаційна, матеріальна, підготовка персоналу, зокрема керівного, не мають достатнього функціонального наповнення. Авторами запропоновані шляхи розв’язання зазначених проблем. Реалізація розроблених у роботі пропозицій дасть змогу завершити формування повноцінної системи управління безпекою польотів державної авіації України, забезпечити її подальше функціонування та наблизити перспективу набуття взаємосумісності з аналогічними системами країн – членів НАТО.
Досвід організації роботи військово-лікарських комісій в умовах передової госпітальної бази
Authors: Остащенко Т. М. , Верба А. В. , Криворучко В. О. , Костюк С. В. , Мірошниченко Д. І. , Савічан К. В. 
Published: October 2023

З початком повномасштабної російської агресії проти України навантаження на існуючі військово-лікарські комісії значно зросло. У складі передової госпітальної бази створені позаштатні постійно діючі військово-лікарські комісії, аналіз роботи яких є актуальним. Мета роботи – аналіз та узагальнення практичного досвіду організації роботи військово-лікарських комісій під час виконання спеціальних завдань медичного забезпечення діючих угруповань військ Сил оборони держави.
Результати. Проведено аналіз та узагальнено досвід організації роботи військово-лікарських комісій, структури їхніх постанов та причин визнання військовослужбовців обмежено придатними до військової служби.
Висновки. За результатами діяльності військово-лікарських комісій передової госпітальної бази 67,4% оглянутих військовослужбовців визнано придатними до військової служби, а 14,4% – обмежено придатними. Виявлено різницю рангового розподілу діагностованих захворювань з переважанням травм, а також причин обмеженої придатності з переважанням хвороб системи кровообігу. Установлено, що серед причин визнання військовослужбовців обмежено придатними значну частину становлять хронічні захворювання, насамперед хвороби системи кровообігу та кістково-м’язової системи і сполучної тканини.
Decision Support System for Addressing Demotivated Students: A Comparative Analysis of SAW and TOPSIS Methods
Authors: Ariftiarno Reza , Triyono Gandung , Rinaldi Ery 
Published: October 2023

Abstract
This study aims to determine the most optimal decision support system method and decision alternatives in the Accounting and Management study program, University of X which has experienced a decrease in learning interest or demotivation so that the study program can take special care for these students to continue studying. The methods used in this study are the SAW and TOPSIS methods with the criteria of GPA, time of study, parents' income, and distance from home. The test results show that the SAW method has the highest preference value compared to the TOPSIS method of 0.992 so it is feasible to apply in the Accounting and Management study program, University X, Bogor City.
Penelitian ini bertujuan untuk menentukan metode sistem pendukung keputusan yang paling optimal serta alternatif keputusan di program studi Akuntansi dan Manajemen, Universitas X yang mengalami penurunan minat belajar atau demotivasi sehingga pihak program studi dapat mengambil penangan khusus terhadap mahasiswa tersebut agar tetap melanjutkan perkuliahan. Metode yang digunakan pada penelitian ini, yaitu metode SAW dan TOPSIS dengan kriteria IPK, waktu studi, pendapatan orang tua, dan jarak rumah. Hasil uji menunjukan bahwa metode SAW memiliki nilai preferensi paling tinggi dibanding metode TOPSIS sebesar 0,992 sehingga layak diterapkan di program studi Akuntansi dan Manajemen, Universitas X, Kota Bogor.
A QUEM INTERESSAM MINHAS MEMÓRIAS DANÇADAS NA ESCOLA?
Authors: Nascimento Eder Fernando 
Published: October 2023

Este artigo busca refletir sobre a autobiografia e as narrativas de vida como processos de formação e auto-identificação dentro da perspectiva da dança e da educação. Para tanto, parto de minhas próprias narrativas para abordar a dança na escola pública de educação básica e principalmente em como minha trajetórias no ambiente educacional — de estudante a professor — contribuiu para minhas concepções de arte, dança e educação, me transformando, hoje, em um artistaprofessor. O objetivo com estas reflexões é explorar a forma como as narrativas de vida podem contribuir não só como registros de experiências vivenciadas, mas também como um processo de reconhecimento de si e identificação do passado como construtor de experiências presentes e futuras, principalmente no que se refere às condutas no ensino de dança e na construção de espaços de arte e cultura dentro do ambiente educacional. Como referencial teórico, a dança é evidenciada pelas contribuições de Marques (2010) e Onuki (2010), os conceitos de experiências são pautados nas contribuições de Dewey (2010) e Larrosa (2019); História de Vida, Saberes Docentes e Formação em Tardif ( 2010), Nóvoa (2022, 2003, 2019) e Cavaco (2015); e as Narrativas biográficas em Delory - Momberger (2011, 2006, 2021). Dessa forma, proponho com este trabalho uma pausa e uma reflexão sobre si (e no meu caso, sobre mim mesmo) e no meu fazer arte-dança-ensino e em como as relações de afeto e de ultrapassar barreiras contribuem para a construção de um meio educacional mais humano.

Palavras-Chave: Dança educação; narrativas biográficas; experiência; processo de formação
Regulation of astrocyte activity and immune response on graphene oxide-coated titanium by electrophoretic deposition
Authors: Han Yong-Soo , Jang Jun-Hwee , Lee Won-Seok , Oh Jun-Sung , Lee Eun-Jung , Yoon Bo-Eun 
Published: October 2023

Introduction: Astrocytes play crucial role in modulating immune response in the damaged central nervous system. Numerous studies have investigated the relationship between immune responses in astrocytes and brain diseases. However, the potential application of nanomaterials for alleviating neuroinflammation induced by astrocytes remains unexplored.Method: In this study, we utilized electrophoretic deposition (EPD) to coat graphene oxide (GO) onto titanium (Ti) to enhance the bioactivity of Ti.Results: We confirmed that GO-Ti could improve cell adhesion and proliferation of astrocytes with upregulated integrins and glial fibrillary acidic protein (GFAP) expression. Moreover, we observed that astrocytes on GO-Ti exhibited a heightened immune response when exposed to lipopolysaccharide (LPS). Although pro-inflammatory cytokines increased, anti-inflammatory cytokines and brain-derived neurotrophic factors involved in neuroprotective effects were also augmented through nuclear localization of the yes-associated protein (YAP) and nuclear factor kappa B (NF‐κB).Discussion: Taken together, GO-Ti could enhance the neuroprotective function of astrocytes by upregulating the expression of anti-inflammatory cytokines and neuroprotective factors with improved cell adhesion and viability. Consequently, our findings suggest that GO-Ti has the potential to induce neuroprotective effects by regulating cell activity.
Sec8 specifically interacts with the PDZ2 domain of synapse associated protein 102 (SAP102)
Authors: Korbula Katharina , Hammerschmid Iana , Lesigang Johannes , Dong Gang 
Published: October 2023

The exocyst is an evolutionarily conserved protein complex tethering secretory vesicles before their docking and fusion with the plasma membrane. The complex also plays important roles in cell migration, synaptogenesis, and neurite outgrowth. One of its subunits, Sec8, was reported to interact with two major synaptic scaffolding proteins SAP102 and PSD-95 that share high sequence homology and contain three PDZ domains at their N-terminal region. The interaction is via the binding of the C-terminal ITTV motif in Sec8 to the PDZ domains of the two synaptic proteins. However, it remains elusive to which PDZ domain(s) Sec8 binds and how their interaction occurs. Here we reported a 2.5 Å resolution crystal structure of the C-terminal half of rat Sec8 containing the ITTV motif. The structure shows that Sec8 contains an enormously long helix at its C-terminus, which bears a unique long “spacer” of 14 residues to bridge the ITTV motif to the compact core of Sec8. We found that Sec8 preferentially binds PDZ2 over PDZ1 and PDZ3 of SAP102. Deletion of the spacer completely abolished the binding of Sec8 to SAP102. Overall, our structural studies, biochemical data and modeling analyses altogether provide an explanation for how Sec8 interacts with SAP102.
Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo
Authors: Shlepova O. V. , Shulepko M. A. , Shipunova V. O. , Bychkov M. L. , Kukushkin I. D. , Chulina I. A. , Azev V. N. , Shramova E. I. , Kazakov V. A. , Ismailova A. M. , Palikova Y. A. , Palikov V. A. , Kalabina E. A. , Shaykhutdinova E. A. , Slashcheva G. A. , Tukhovskaya E. A. , Dyachenko I. A. , Murashev A. N. , Deyev S. M. , Kirpichnikov M. P. , Shenkarev Z. O. , Lyukmanova E. N. 
Published: October 2023

α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells. Here, we investigated mechanisms of antiproliferative activity of recombinant SLURP-1 in epidermoid carcinoma A431 cells and activity of SLURP-1 and synthetic 21 a.a. peptide mimicking its loop I (Oncotag) in a xenograft mice model of epidermoid carcinoma. SLURP-1 inhibited the mitogenic pathways and transcription factors in A431 cells, and its antiproliferative activity depended on α7-nAChR. Intravenous treatment of mice with SLURP-1 or Oncotag for 10 days suppressed the tumor growth and metastasis and induced sustained changes in gene and microRNA expression in the tumors. Both SLURP-1 and Oncotag demonstrated no acute toxicity. Surprisingly, Oncotag led to a longer suppression of pro-oncogenic signaling and downregulated expression of pro-oncogenic miR-221 and upregulated expression of KLF4 protein responsible for control of cell differentiation. Affinity purification revealed SLURP-1 interactions with both α7-nAChR and EGFR and selective Oncotag interaction with α7-nAChR. Thus, the selective inhibition of α7-nAChRs by drugs based on Oncotag may be a promising strategy for cancer therapy.
Zmym4 is required for early cranial gene expression and craniofacial cartilage formation
Authors: Jourdeuil Karyn , Neilson Karen M. , Cousin Helene , Tavares Andre L. P. , Majumdar Himani D. , Alfandari Dominique , Moody Sally A. 
Published: October 2023

Introduction: The Six1 transcription factor plays important roles in the development of cranial sensory organs, and point mutations underlie craniofacial birth defects. Because Six1’s transcriptional activity can be modulated by interacting proteins, we previously screened for candidate interactors and identified zinc-finger MYM-containing protein 4 (Zmym4) by its inclusion of a few domains with a bona fide cofactor, Sine oculis binding protein (Sobp). Although Zmym4 has been implicated in regulating early brain development and certain cancers, its role in craniofacial development has not previously been described.Methods: We used co-immunoprecipitation and luciferase-reporter assays in cultured cells to test interactions between Zmym4 and Six1. We used knock-down and overexpression of Zmym4 in embryos to test for its effects on early ectodermal gene expression, neural crest migration and craniofacial cartilage formation.Results: We found no evidence that Zmym4 physically or transcriptionally interacts with Six1 in cultured cells. Nonetheless, knockdown of endogenous Zmym4 in embryos resulted in altered early cranial gene expression, including those expressed in the neural border, neural plate, neural crest and preplacodal ectoderm. Experimentally increasing Zmym4 levels had minor effects on neural border or neural plate genes, but altered the expression of neural crest and preplacodal genes. At larval stages, genes expressed in the otic vesicle and branchial arches showed reduced expression in Zmym4 morphants. Although we did not detect defects in neural crest migration into the branchial arches, loss of Zmym4 resulted in aberrant morphology of several craniofacial cartilages.Discussion: Although Zmym4 does not appear to function as a Six1 transcriptional cofactor, it plays an important role in regulating the expression of embryonic cranial genes in tissues critical for normal craniofacial development.
The influence of substituents in governing the strength of the P–X bonds of substituted halophosphines R1R2P–X (X = F and Cl)
Authors: O’Reilly Robert J. , Karton Amir 
Published: October 2023

In this study, the gas-phase homolytic P–F and P–Cl bond dissociation energies (BDEs) of a set of thirty fluorophosphine (R1R2P–F) and thirty chlorophosphine-type (R1R2P–Cl) molecules have been obtained using the high-level W2 thermochemical protocol. For the R1R2P–F species, the P–F BDEs (at 298 K) differ by up to 117.0 kJ mol−1, with (H3Si)2P–F having the lowest BDE (439.5 kJ mol−1) and F2P–F having the largest BDE (556.5 kJ mol−1). In the case of the chlorophosphine-type molecules, the difference in BDEs is considerably smaller (i.e., 72.6 kJ mol−1), with (NC)2P–Cl having the lowest P–Cl BDE (299.8 kJ mol−1) and (HO)2P–Cl having the largest (372.4 kJ mol−1). We have further analyzed the effect of substituents in governing the P–F and P–Cl BDEs by considering the effect of substituents in the parent halogenated precursors (using molecule stabilization enthalpies) and the effect of substituents in the product radicals (using radical stabilization enthalpies). Finally, we have also assessed the performance of a wide range of DFT methods for their ability to compute the gas-phase P–F and P–Cl BDEs contained in this dataset. We find that, overall, the double hybrid functional DSD-PBEB95 offers the best performance for both bond types, with mean absolute deviations of just 2.1 (P–F BDEs) and 2.2 (P–Cl BDEs) kJ mol−1.
Specific genetic aberrations of parathyroid in Chinese patients with tertiary hyperparathyroidism using whole-exome sequencing
Authors: Li Lei , Sheng Qixuan , Zeng Huajin , Li Wei , Wang Qiang , Ma Guanjun , Xu Xinyun , Qiu Ming , Zhang Wei , Shan Chengxiang 
Published: October 2023

BackgroundTertiary hyperparathyroidism (THPT) is a peculiar subtype of hyperparathyroidism that usually develops from chronic kidney disease (CKD) and persists even after kidney transplantation. Unlike its precursor, secondary hyperparathyroidism (SHPT), THPT is characterized by uncontrolled high levels of calcium in the blood, which suggests the monoclonal or oligoclonal proliferation of parathyroid cells. However, the molecular abnormalities leading to THPT have not yet been fully understood.MethodsIn this study, we analyzed DNA samples from hyperplastic parathyroid and corresponding blood cells of 11 patients with THPT using whole-exome sequencing (WES). We identified somatic single nucleotide variants (SNV) and insertions or deletions variants (INDEL) and performed driver mutation analysis, KEGG pathway, and GO functional enrichment analysis. To confirm the impact of selected driver mutated genes, we also tested their expression level in these samples using qRT-PCR.ResultsFollowing quality control and mutation filtering, we identified 17,401 mutations, comprising 6690 missense variants, 3078 frameshift variants, 2005 stop-gained variants, and 1630 synonymous variants. Copy number variants (CNV) analysis showed that chromosome 22 copy number deletion was frequently observed in 6 samples. Driver mutation analysis identified 179 statistically significant mutated genes, including recurrent missense mutations on TBX20, ATAD5, ZNF669, and NOX3 genes in 3 different patients. KEGG pathway analysis revealed two enriched pathways: non-homologous end-joining and cell cycle, with a sole gene, PRKDC, involved. GO analysis demonstrated significant enrichment of various cellular components and cytobiological processes associated with four genes, including GO items of positive regulation of developmental growth, protein ubiquitination, and positive regulation of the apoptotic process. Compared to blood samples, THPT samples exhibited lower expression levels of PRKDC, TBX20, ATAD5, and NOX3 genes. THPT samples with exon mutations had relatively lower expression levels of PRKDC, TBX20, and NOX3 genes compared to those without mutations, although the difference was not statistically significant.ConclusionThis study provides a comprehensive landscape of the genetic characteristics of hyperplastic parathyroids in THPT, highlighting the involvement of multiple genes and pathways in the development and progression of this disease. The dominant mutations identified in our study depicted new insights into the pathogenesis and molecular characteristics of THPT.