bluuebunny/crossref_metadata_2025_split huggingface dataset:
10-Hydroxydec-2-enoic acid enhances the erythrocyte membrane fluidity via interacting with phosphatidylcholine and phosphatidylethanolamine
Authors: Sha Fangfang , Yang Peichang , Wang Hui , Ren Junhua , Li Zirui , Zhang Lu , Fan Pei 
Published: December 2023

10-Hydroxydec-2-enoic acid (10-HDA), the unique substance in the natural food royal jelly, is an unsaturated hydroxyl fatty acid with the bio-activity to guard against cell or tissue damages. However, the relevant mechanisms still remain largely unknown. Here, using a mouse erythrocyte model, whether the fluidity of plasma membrane is influenced by 10-HDA was investigated. 10-HDA was shown to enhance the erythrocyte membrane fluidity and to rescue the fluidity from •OH toxicity. In such occasions, 10-HDA promoted the dissolved O2 level in erythrocyte suspension thereof. The levels of β-actin and band 4.1 protein were not affected by 10-HDA in erythrocytes. In the framework of density functional theory, 10-HDA may interact with phosphatidylcholine and phosphatidylethanolamine, the major components of membrane lipid bilayer. This was evidenced by the fact that 10-HDA was detectable in erythrocytes after its addition to the erythrocyte suspension. Moreover, the fluorescent intensity of erythrocytes stained by the membrane probe DiIC18(5) increased with 10-HDA treatment. Hence, 10-HDA could regulate the erythrocyte membrane fluidity and the release of O2 from erythrocytes via targeting lipids rather than proteins. Our data cast light on the elucidation of the mechanism of 10-HDA modulating cell functionality and the utilization of 10-HDA in remedying the erythrocyte membrane fluidity-associated symptoms.
Follow effect of low cost glass fibre reinforced polymer (GFRP) on the performance of concentrically loaded concrete column
Authors: Pannirselvam N  , Sudarsan J S  , Nithiyanantham S  
Published: December 2023

(FRP) plays a major role in the strengthening of existing structures due to the age of the structure or natural calamities like earthquakes, floods, cyclones, etc. For reducing the size of structural members, the FRP wrapping assists to achieve the performance of the structure. Concrete is widely used due to its advantages and FRP is added to improve its quality in terms of strength. A study has been conducted on 21 cylinders based on their slenderness ratio. The slenderness ratios in the columns were 8, 16, and 24. At thicknesses of 5 mm and 7 mm, two types of wrap materials (UDCGFRP) and (WRGFRP)] were employed. Up to the point of failure, the columns were subjected to monotonic axial compressive force. The column’s yield loads, and ultimate load, were deduced from the load-deflection curves. The overall, uni-directional cloth provided the most effective confinement and led to a highly desirable failure mechanism, which was a gradual process.
Diagnostic potential of plasma CD30(+) small extracellular vesicles in Hodgkin lymphoma
Authors: Katsuba K. E. , Kramynin L. A. , Slyusarenko M. A. , Shalaev A. V. , Sharoyko V. V. , Valitova A. A. , Artem’eva A. S. , Krzhivitskiy P. I. , Filatova L. V. , Malek A. V. 
Published: December 2023

Background. In current clinical practice, there are no reliable methods to stratify patients with a high risk of relapse or with a primary refractory form of Hodgkin lymphoma. Quantification of CD30-positive small extracellular vesicles (CD30(+)SEV) in plasma seems to be a possible approach to solve this issue. CD30(+)SEV can be quantified by the AuNP aptasensor technology based on the enzyme-mimetic properties of gold nanoparticles and the CD30-specific affinity of DNA aptamers.Aim. To quantify CD30(+)SEV in the plasma of patients with newly diagnosed Hodgkin lymphoma; to investigate the links between estimated parameter and clinical/morphological properties of disease and the effect of first two chemotherapy cycles.Material and methods. A semi-quantitative analysis of CD30(+)SEV in the plasma of patients with Hodgkin lymphoma (n = 55) was performed using the AuNP aptasensor. The relationship between the CD30(+)SEV concentration and the data of standard diagnostic approaches was evaluated through the r-Pearson correlation coefficient, the Mann–Whitney and Kruskal–Wallis criteria.Results. The plasma concentration of CD30(+)SEV in patients with Hodgkin lymphoma correlates with the quantity of CD30(+) cells in tissues of biopsied lymph nodes (r = 0.8) and the total lesion glycolysis estimated by PET/CT (r = 0.9). Patients with a relatively high concentration of CD30(+)SEV are characterized by an increase of erythrocyte sedimentation rate and leukocytosis compared with patients with a lower concentration of CD30(+)SEV. Two cycles of chemotherapy reduced CD30(+)SEV concentration, and this effect was more pronounced in patients treated with ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) regime than the BEACOPPesc (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, prednisolone, procarbazine).Conclusion. AuNP-aptasensor can be used for semi-quantitative assessment of CD30(+)SEV in plasma. The estimated CD30(+)SEV concentration correlates with the clinical and morphological parameters of patients with Hodgkin lymphoma and may reflect the severity of the disease. To assess the diagnostic and/or prognostic potential of developed technology, large-scale multicenter studies are required.
PD-1 and LAG-3 as early prognostic markers in the treatment of patients with chronic lymphocytic leukemia
Authors: Selyutina O. N. , Lysenko I. B. , Guskova N. K. , Novikova I. А. , Zlatnik E. Yu. , Pushkareva T. F. , Nikolaeva N. V. , Kamaeva I. A. , Kapuza E. A. , Gaysultanova Ya. S. , Rozenko L. Ya. 
Published: December 2023

Background. Recently, studies have been conducted all over the world to study the role of immune checkpoints in the pathogenesis of chronic lymphocytic leukemia (CLL) and the possibility of their use as prognostic markers. Of greatest interest are PD-1 (programmed cell death-1) and LAG-3 protein (lymphocyte-activation gene 3).Aim. To study the features of PD-1 (CD279) and LAG-3 (CD223) expression on blood B-cells of CLL patients and the possibility of their use as early markers for predicting the hematological response to therapy.Materials and methods. The blood of 30 patients with CLL in stage C according to Binet and 20 healthy individuals was studied by 10-color flow cytometry.Results. In patients with CLL, there were significant differences in the initial lymphocytes level, PD-1 and LAG-3 expression on B-lymphocytes, both with persons in the control group and among themselves with different hematological responses to therapy with rituximab according to the results of minimal residual disease monitoring.Conclusion. PD-1 and LAG-3 can be used as early markers for predicting the response of CLL patients to therapy. The combined use of initial lymphocytes level and PD-1 and LAG-3 expression on CD19+ blood cells has a greater prognostic value. New data obtained from the study of immune checkpoints PD-1 and LAG-3 may be useful in the development of targeted therapeutic agents.
Formaldehyde Adulteration in Meatball is Still Prevalent, and it is Hard to Identify Only from its Physical Properties
Authors: Pratama Yoga , Astuti Asri , Setiani Bhakti Etza 
Published: December 2023

Human carcinogenic compound formaldehyde (alternative name, formalin) adulteration in food is inappropriate and illegal. However, its simple and cheap procedure in giving desired food preservation effect becomes the factor of its prevalence in Indonesian community. Our current study focuses on the usage of formaldehyde in meatball products which are sold in bulk without refrigeration in traditional market set up. Eighty different packages of meatballs were collected following accidental sampling method from small groceries in Tembalang, Semarang, Central Java in 2019. Samples were characterized for their formaldehyde content (AOAC 931.08), total plate count, moisture and organoleptic properties. Formaldehyde was found in 1 sample at the level of 176.2 ppm. Whereby, it was among only 4 % of samples that met the maximum microbial limit of 5 log CFU/g. The particular sample was characterized by pale color, rather slimy surface, chewy and weak meatball aroma. Note, this characteristic is not unique and is shared by several other samples. Therefore, this study brings an update that formaldehyde adulteration is still prevalent. The adulterated product has hardly distinctive sensorial properties which make self-evaluation difficult, thus exposing consumers to potential food safety risks.
Liver Cancer Segmentation through Enhanced Feature Extraction and Mapping using Improved Transfer Learning Techniques
Authors: N.A. Sheela Selvakumari C. Clement Sherlin, 
Published: December 2023

The largest solid organ in the body is the liver. Numerous other vital functions it carries out include removing impurities from the blood flow, controlling blood coagulation, and maintaining healthy blood sugar levels. All blood leaving the intestines and stomach is directed to the liver as its final destination. Liver illness may be brought on by infections, inherited diseases, cancer, too many harmful substances, or other conditions. Medical experts estimate that 1.6% of men and women in India could be diagnosed with liver cancer at some time in their life. The interpretation of liver CT scans often involves semi-manual or manual techniques; however these techniques are costly, time-consuming, subjective, and prone to error. To improve the detection of liver cancer, these issues have been addressed and a number of computer algorithms have been developed. To create a fully automated method for quickly extracting liver tumours from CT scan images.
Image based ECC Mutual Authentication Scheme for Cloud Assisted TMIS
Authors: Syed Amma Sheik Et al. 
Published: December 2023

In this modern era, cloud-based services like e-commerce, e-gate, and so on provide immense services to humans. Healthcare centers are gradually moving to cloud-based services. In which, both the hospital and patients are connected remotely online and patient gets treatment quickly. Increasing the demand in Telecare Medical Information System (TMIS) needs to ensure the security and privacy of the healthcare centers and patients’ information. In this paper, we have proposed an e?cient and provably secure Elliptic Curve cryptography image based mutual authentication scheme for cloud assisted TMIS. The proposed authentication schemes ensure the secured treatment provided to patients from healthcare center through online. The patient can upload their health condition data to cloud via mobile device for the treatment. The proposed authentication scheme required minimum computational cost with minimum communication overhead. The proposed authentication scheme preserves patient anonymity and withstands the known and chosen plaintext attack. The security analysis for the proposed scheme shows that the proposed authentication scheme is more secure. It shows that the proposed authentication scheme is performing well compare to the related authentication schemes.
Remarkable direct formic acid electrocatalysis enabled by rare earth-doped platinum-tellurium heterostructures
Authors: Bu Lingzheng , Lin Xin , Geng Shize , Du Xianglong , Wang Feiteng , Zhang Xu , Xiao Fang , Xiao Zhengyi , Wang Yucheng , Cheng Jun , Zheng Zhifeng , Huang Xiaoqing 
Published: December 2023

Abstract

The lack of new high-efficiency platinum (Pt)-based nanomaterials remains a formidable and exigent challenge in achieving high formic acid oxidation reaction (FAOR) and membrane electrode assembly (MEA) catalysis for direct formic acid fuel cell (DFAFC) technology. Herein, by adopting a synergistic amalgamation strategy, we report 16 types of Pt-based heterophase nanotrepang with rare earth (RE)-doped face-centered cubic Pt (fcc-Pt) and trigonal Pt-tellurium (t-PtTe2) configurations ((RE-Pt)-PtTe2 HPNT) to largely boost the FAOR and MEA catalysis. Comprehensively considering all the non-radioactive RE elements, yttrium (Y) is demonstrated to be the optimized doped element, coexisting as the forms of single site and cluster on the surface. The resulted (Y-Pt)-PtTe2 HPNT/C exhibits a competitive mass activity of 6.4 A mgPt-1, outperforming commercial Pt/C by 50.5 times. Simultaneously, it achieves the normalized MEA power density of 281.9 W gPt-1, 2.4 times higher than that of commercial Pt/C, demonstrating a large potential for DFAFC device application. The experimental findings evidence the key role of beneficial surface compositions of Y-doped fcc-Pt and t-PtTe2, significantly hindering the formation of CO intermediate and promoting the reaction kinetics. Density functional theory calculations further reveal the efficacy of Y doping, which predominantly locates on the high-energy Pt (110) facet and heightens the binding energy barrier with CO intermediate. The dehydrogenation pathway can be effectively promoted by enhancing the decomposition of formic acid and accelerating the conversion of reaction intermediates, resulting in the remarkable direct FAOR performance. This work achieves the high electrocatalysis in both FAOR and MEA media, highlighting the profound importance of RE metals served as favorable doping forms in heterostructure regulation of newly-designed Pt-based anodic nanomaterials for fuel cells and beyond.
Detection of Violent Elements in Digital Games Using YOLO V7 Algorithm
Authors: YALÇIN Nursel , ÇAPANOĞLU Ahmet Edip 
Published: December 2023

Abstract
Digital games have various useful purposes such as entertainment, education, attention strengthening, and strategy development, but they can also negatively affect users with harmful content such as violence, gambling, sexuality, profanity, and drugs. Especially for children at a young age, these elements can settle into their subconscious and negatively affect their lives in the future. Violence elements such as gun, knife, fights, fire, and blood are very common in digital games in many different forms. Real-time detection of these violence elements is crucial to enable early intervention in possible problems. In this study, violence elements within digital games were examined, and a deep learning method was proposed to detect these elements such as guns, knives, bombs, fire, blood, and fights. Additionally, the detection of these violence elements in digital games was performed using YOLOV7. The proposed model was trained on Google Colab, and test results showed that it could be used for real-time digital games with high accuracy performance and detection speed.
Intramedullary Nailing at Different Distal Tibial Fracture Levels: A Biomechanical Study
Authors: Guran Ortac , Ozmanevra Ramadan , Husemoglu Resit Bugra , Havitçıoglu Hasan , Altinoz Ozenc 
Published: December 2023

Abstract
Purpose: Distal tibial fractures remains a significant challenge in orthopedic trauma surgery. The aim of this study was to investigate the biomechanical stability of intramedullary nailing (IMN) at different distal tibial fracture levels and the effect of the number of locking screws.
Methods: Using a total of 21 sawbone models, three different tibial fracture levels (3, 4.5, and 6cm proximally to the talocrural joint) were created and the fractures were fixed using two, three, or four distal locking screws. A single compression test and a cyclic compression test was applied to all tibia models. The applied weight and displacements from the fracture lines were recorded and evaluated.
Results: There was no statistically significant difference in fixation with two distal locking screws in groups 1, 2, and 3 (single test p=0.9689) (cyclic test p=0.8050). Therefore, if two distal screws are used, the fracture level does not affect the strength of fixation. In fractures located 6 cm proximal to the talocrural joint, all four holes of the nail can be used to insert screws, which provides a stronger fixation. When two screws are used, a statistically weaker fixation is obtained than with three or four screws.
Conclusion: Our findings support the use of IMN with two distal locking screws as a viable option for the management of distal tibial fractures. We found that it provides sufficient fixation regardless of the fracture level, suggesting that there is no need to choose an alternative fixation technique due to concerns of inadequate fixation as the fracture line moves distally. In cases where more stable fixation is desired, an additional locking screw can be used.
Benchmarking the university campus food environment and exploring student perspectives about food insecurity and healthy eating: a case study from Australia
Authors: Keat Jemma , Dharmayani Putu Novi Arfirsta , Mihrshahi Seema 
Published: December 2023

Abstract

Objective:
To benchmark the university food environment and explore students’ experiences with food insecurity and healthy eating in order to inform interventions to improve access and affordability of healthy foods for university students.
Design:
A food environment audit was conducted on the university campus using the Uni-Food tool from April to May 2022 and was comprised of three main components, university systems and governance, campus facilities and environment, and food retail outlets. A qualitative study design was also used to conduct focus groups and semi-structured interviews with students to explore key themes regarding their experiences with food insecurity and healthy eating.
Setting:
Macquarie University, Australia.
Participants:
For the food environment audit 24 retail outlets on campus and for the qualitative component 29 domestic and international students enrolled at Macquarie University.
Results:
The university only scored 27% in total for all components in the food environment audit. The results showed the need for better governance and leadership of the food environment. The qualitative component suggested that the main barriers to accessing healthy foods were related to availability, pricing, and knowledge of healthy foods. Future intervention ideas included free fruits and vegetables, food relief, discounts, improved self-catering facilities, education, and increased healthy food outlets.
Conclusions:
Improving governance measures related to healthy eating on campus are a core priority to strengthen the food environment and students identified pricing and availability as key issues. These findings will inform effective and feasible interventions to improve food security and healthy eating on campus.
JMJD6 promotes radioresistance of non-small cell lung cancer via epigenetic regulation of EHF
Authors: Wang Manni , Chen Siyuan , He Xuemei , Alu Aqu , Pu Qiang , Wei Xiawei 
Published: December 2023

Abstract
Though radiation therapy (RT) is widely used in lung cancer at all stages for local tumor control, the long-term efficacy of radiotherapy is largely restricted by radioresistance as frequently observed in the clinical setting, eventually leading to cancer recurrence. With the advent of targeted therapies, we observed a dramatic uptick in the clinical outcomes of non–small cell lung cancer (NSCLC) patients. JMJD6 was initially identified as an arginine 2 histone H3 (H3R2) and arginine 3 histone H4 (H4R3) arginine demethylase, and was later confirmed to be closely related to the occurrence and development of various cancers. In the present study, we found that RT induced the upregulation of JMJD6 which promoted the transcription of Ets homologous factor (EHF) and downstream pluripotency factor genes via the demethylation of H4R3me2s. Analyses results from matched human NSCLC tissues demonstrated that JMJD6 was upregulated in radioresistant NSCLC cells and in tumors of NSCLC patients, which indicated worse prognosis and higher metastasis risk in patients. These findings are of therapeutic importance for the design of novel therapies to prevent post-RT metastasis and to improve the long-term efficacy of radiotherapy in lung cancer.
Resiliensi Kawasan Permukiman Desa Pacarejo, Semanu, Kabupaten Gunung Kidul Terhadap Bencana Alam Puting Beliung
Authors: Lestarianto Aris Nur , Bawole Paulus , Nainggolan Freddy Marihot Rotua 
Published: December 2023

Title: Resilience of the Settlement Area of Pacarejo Village, Semanu, Gunung Kidul Regency Against the Natural Disaster of Tornado

Natural disaster is a natural phenomenon often faced in several countries, including Indonesia, which has a variety of potential disasters. Pacarejo Village is an area in the Kapanewon Semanu, Gunung Kidul Regency, Daerah Istimewa Yogyakarta, which often experiences natural disasters. One of the natural disasters that often occurs in this region is the natural disaster of tornadoes. In this area, tornadoes have occurred several times, and on February 22, 2022, this disaster caused damage to residential areas, both houses and their surrounding environment. On the one hand, tornado disasters hurt people's lives, but on the other hand, they can also generate resilience in residential areas. This resilience makes the residential area in Pacarejo Village resistant and resilient to tornado disasters. This research aims to find out how the resident areas in Pacarejo Village are resilient to tornado disasters. The research method used is a qualitative method, which requires a narrative to explain the research systematically and accurately according to existing facts and data. The results of this research will show and provide lessons on how the resilience of the residential area formed in the Pacarejo District can face tornado disasters.
Biodiversity in wetland+ system: a passive solution for HCH dump effluents
Authors: Amirbekov Aday , Strojsova Martina , Nemecek Jan , Riha Jakub , Hrabak Pavel , Arias Carlos , Sevcu Alena , Černík Miroslav 
Published: December 2023

Abstract

The hexachlorocyclohexane isomers (HCH) are long-banned pesticides. Even though their use has been prohibited for decades, their presence in the environment is still reported worldwide. Wetland + is a registered trademark of the remedial treatment technology consisting of an aerobic sedimentary tank, a permeable reactive barrier, a biosorption system, and an aerobic wetland. This proven method combines a reductive treatment known from PRBs with the natural wetland self-cleaning processes. The average efficiency of the system is 96.8% for chlorobenzenes (ClB) and 81.7% for HCH, during the first 12 months of the system operation. The presence of the genes encoding enzymes involved in the degradation of the HCH compounds indicates that the removal of HCH and ClB occurs not only by chemical removal but also through aerobic and anaerobic combining biodegradation. Changes in abundance and the composition of the diatom community were found to be suitable indicators of the water quality and of the impact of the Wetland + operation on the water ecosystem. The system's annual operation exhibited a markedly higher number of diatom species in the closing profiles of the Ostrovský Creek, the Wetland + effluent recipient.
Influence of ‘Bergendang’ Culture in the Spaces of Traditional Sarawak Malay House
Authors: Samat Yon Syafni , Ariffin Syed Iskandar , Abdullah Goh Nurakmal , Ting John H.S. 
Published: December 2023

Bergendang is a uniquely Sarawak Malay traditional entertainment frequently held during social gatherings . This paper investigates the spatial use of bergendang activity in traditional Malay houses along the Sarawak River in Kuching. The research employed a qualitative case study design approach through field study observation and semi-structured interviews. Findings revealed different spatial use of bergendang for the early and later models of Sarawak Malay houses, which is associated with house owners’ social status. Spatial studies on traditional Malay houses in other parts of Sarawak are recommended for constructing northern Borneo's vernacular Malay house framework