bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of PON1-L55M Genetic Variation with Idiopathic Male Infertility in an Iranian Population: A Case-Control Study
Authors: Mortezapour Hanie , Colagar Abasalt Hosseinzadeh , Fallah Fatemeh , Taravati Ali , Jorsaraei Ali 
Published: October 2023

Abstract
The risk of male infertility is related to gene polymorphisms that reduce the activity of antioxidant enzymes. Serum paraoxonase 1 (PON1), is an antioxidant calcium-dependent enzyme has been implicated in the pathogenesis of male infertility. This study aimed to explore the relationship between PON1-L55M polymorphism with idiopathic male infertility. In this case–control study Semen samples were collected from 77 healthy men controls and 128 infertile donors. The paraoxonase activity of PON1 enzyme were measured by spectrophotometric methods. Genomic DNA was extracted from sperm and rs854560 (L55M) was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR sequencing. Statistical analysis indicated that significant difference in genotype frequencies of PON1 L55M polymorphism between patients and controls. Our results showed that, the men with a MM genotype (p= 0.021; OR= 0.091, CI=0.012-0.7) had a significant increased risk of idiopathic male infertility than those with a LM genotype (p= 0.013; OR=0.418, CI=0.27-0.855). In addition, PON1 activities in LL genotype were the highest than LM and MM genotype respectively (MM<LM<LL) in both patients and controls. So, the PON1-L55M is more likely to be a risk factor for idiopathic infertility in Iranian men. Based on the findings of this study, PON1 rs854560 (L55M) variation may be related to semen PON1 activity and the risk of idiopathic male infertility in Iranian population. Nevertheless, we suggested that, future studies focused on some factors such as, environmental and epigenetic factors in larger sample size are needed to reach accurate results.
Quality of working life in relation to occupational stress, anxiety and depression of workers in primary and secondary healthcare workplaces.
Authors: Sotiria Barbagianni , Ioannis Moisoglou , Meimeti Evangelia , Ioanna Dimitriadou , Marilena Gialama , Petros Galanis 
Published: October 2023

Abstract
Background
Healthcare professionals work in a demanding working environment, due to which they may develop high levels of stress, anxiety and depression.
Aims
To assess the quality of working life of healthcare professionals and to investigate the association between stress, anxiety and depression and the quality of working life.
Methodology:
A cross-sectional study implemented in two primary healthcare centers and a general hospital in Greece, between January to February 2020. A total of 248 healthcare professionals participated. The Depression, Anxiety and Stress Scale (DASS 21) and the Professional Quality of Life Scale (ProQOL) were used.
Results
Healthcare professionals had normal stress (10.11), depression (6.69), anxiety (5.10) and appeared to had moderate quality in their working life. The quality of the working life was found to be influenced by educational level, as the level of education increases, occupational burnout (p = 0.015) and secondary traumatic stress (p = 0.001) decrease. Correlation of the demographic characteristics of the sample and the DASS-21 scale showed that as the level of education increases, depression, stress and anxiety decrease (p < 0.05). Multivariable linear regression analysis showed that increased depression, anxiety and stress were associated with increased occupational burnout and secondary traumatic stress and on the other hand, decreased depression, anxiety and stress were associated with increased compassion satisfaction.
Conclusions
The study emphasized the significance of the management of healthcare organizations to achieve a reduction of stress, depression and anxiety among healthcare professionals in order to ensure a better-quality working life.
A comprehensive study of various regressions and deep learning approaches for the prediction of friction factor in mobile bed channels
Authors: Bassi Akshita , Mir Ajaz Ahmad , Kumar Bimlesh , Patel Mahesh 
Published: October 2023

Abstract

A fundamental issue in the hydraulics of movable bed channels is the measurement of friction factor (λ), which represents the head loss because of hydraulic resistance. The execution of experiments in the laboratory hinders the predictability of λ over a short period of time. The major challenges that arise with traditional forecasting approaches are due to their subjective nature and reliance on various assumptions. Therefore, advanced machine learning (ML) and artificial intelligence approaches can be utilized to overcome this tedious task. Here, eight different ML techniques have been employed to predict the λ using eight different input features. To compare the performance of models, various error metrics have been assessed and compared. The graphical inferences from heatmap data visualization, Taylor diagram, sensitivity analysis, and parametric analysis with different input scenarios (ISs) have been carried out. Based on the outcome of the study, it has been observed that K Star in the IS1 with correlation coefficient (R2) value equal to 0.9716 followed by M5 Prime (0.9712) and Random Forest (0.9603) in IS2 and IS4, respectively, have provided better results as compared to the other ML models to predict λ in terms of least errors.
An uncertain structure for minimizing the conflict of exploitation policies in common pool groundwater resources
Authors: Xu Yaning , Mao Yi , Fan Yuezhong 
Published: October 2023

Abstract
Creating a structure for allocating water from common pool resources is a serious problem in agricultural water management. In this research, an attempt has been made based on bi-objective optimization and the non-dominated theory to create the water allocation models for the cultivation pattern. The water allocated in each irrigation event was defined as the decision variable in this structure. Two objective functions include the following: (1) maximizing and minimizing the water allocation and (2) minimizing conflicts between beneficiaries in the Hebei Plain. Conflicts between beneficiaries were formulated based on the ratio between the crop area and water allocation and were defined by an inertia weight to increase its effect on the final iterations of the process. The Whale Optimization Algorithm was included as a bi-objective algorithm in the decision-making process. The number of decision variables and feasible domains in each decision model is different and creates a crowding distance for competition between operators. The results showed that the water allocation planning structure based on the evaluation index had the best solution front.
Optimization of the process of decreasing the filtration resistance of sewage sludge by thermal pretreatment: a case study for the Lviv WWTP
Authors: Verbovskyi Orest , Zhuk Volodymyr , Orel Vadym , Popadiuk Ihor 
Published: October 2023

Abstract

The article presents the results of an experimental study of the effect of high-temperature thermal pretreatment on the specific resistance to filtration (SRF) of the sewage sludge (SS) from the Lviv wastewater treatment plant (WWTP), which is a combination of primary sludge and excess-activated sludge collected in primary sedimentation tanks. The kinetics of SRF reduction over time at temperatures of 140 − 150 °С are described by simple exponents, while at temperatures of 160 − 170 °С, they are described by modified two-parameter exponents. The study analyzed the dimensionless optimization function, which is the product of the final relative SRF of the sludge and the dimensionless time of thermal pretreatment. An optimal dimensionless thermal pretreatment time of 4.1 tr.0/2 was determined, and an empirical exponential equation for the time of SRF reduction by twice tr.0/2 was derived. Based on the analysis, it was found that the highest efficiency in reducing the SRF of Lviv WWTP SS occurs at a temperature of 170 °C and an optimal duration of thermal pretreatment of 55 min.
Procedure for emergetic assessment in urban river de-pollution
Authors: Flausino Fabio R. , de Oliveira Neto Geraldo Cardoso , Librantz André F. H. 
Published: October 2023

Abstract
Using emergetic indicators to evaluate complex processes such as the de-pollution of urban rivers aims to contribute to better use and preservation of the resources, besides the valuation of ecosystem services provided by the water body. Within this context, we conducted a bibliometric and systematic review that shows the lack of emergetic indicators in urban river de-pollution. Thus, this work aims to propose an emergetic assessment procedure to evaluate the de-pollution process of urban rivers that allows technicians, academics, and revitalization process managers of urban rivers to improve the monitoring and decision-making directly related to the process, concluding that an emergetic assessment procedure contributes to theory to create new scientific analyses applied to urban revitalization and nature preservation processes. The emergetic assessment procedure contributes to society by improving the disposal of public resources and the effective maintenance of urban rivers that provide ecosystem services to all stakeholders (residents, grantors, and sanitation companies). In practice, the use of the emergetic assessment contributes to the monitoring from the first stages of the clean-up process, demonstrating the sustainability of the process for the adequacy of resources and maintenance of the water body that shall be cleaned.
Optimal design of triangular side orifice using multi-objective optimization NSGA-II
Authors: Danish Mohd , Ayaz Md. 
Published: October 2023

Abstract

Triangular orifices are widely used in industrial and engineering applications, including fluid metering, flow control, and measurement. Predicting discharge through triangle orifices is critical for correct operation and design optimization in various industrial and engineering applications. Traditional approaches like empirical equations have accuracy and application restrictions, whereas computational fluid dynamics (CFD) simulations can be computationally costly. Alternatively, artificial neural networks (ANNs) have emerged as a successful solution for predicting discharge through orifices. They offer a dependable and efficient alternative to conventional techniques for estimating discharge coefficients, especially in intricate relationships between input parameters and discharge. In this study, ANN models were created to predict discharge through the triangle orifice and velocity at the downstream of the main channel, and their effectiveness was assessed by comparing the performance with the earlier models proposed by researchers. This paper also proposes a novel hybrid multi-objective optimization model (NSGA-II) that uses genetic algorithms to discover the best values for design parameters that maximize discharge and downstream velocity simultaneously.
Evaluation of Mobile Health Technology Interventions for the Postdischarge Management of Patients With Head and Neck Cancer: Scoping Review
Authors: Li Yufei , Chen Weihong , Liang Yanjing , Yang Ling , Hou Lili 
Published: October 2023

Background
Patients with head and neck cancer (HNC) often experience various types and degrees of complications and functional impairment following surgery or radiotherapy. Consequently, these patients require extensive postdischarge rehabilitation, either at home or in the community. Numerous studies have shown the advantages of mobile Health (mHealth) technology in assisting patients with cancer with self-management and rehabilitation during the postdischarge period. However, few reviews have focused on the intervention, management, and evaluation of mHealth technology in postdischarge patients with HNC.

Objective
This study aimed to conduct a scoping review of mHealth technology apps and interventions currently available to patients discharged from hospitals after receiving treatment for HNC. This study sought to identify and summarize the types and effectiveness of existing mHealth interventions as well as the differences in their outcome assessments.

Methods
The PubMed, Embase, Web of Science, and CINAHL databases were used to identify studies with no publication time limits. The keywords “mobile health technology” and “head and neck cancer” were combined to address the main concepts of the research questions.

Results
Of the 1625 papers identified, 13 (0.8%) met the inclusion and exclusion criteria. Most studies (n=8, 61.5%) were randomized controlled trials (RCTs) and cohort studies. These studies were conducted in 6 countries. The main aims of the mHealth interventions in these studies are as follows: (1) symptom monitoring and assessment, (2) rehabilitation training, (3) access to medical health information, (4) telehealth advisers, (5) peer communication and support, and (6) follow-up/review reminders. The outcome evaluations of the 13 included studies were grouped into 4 categories: (1) technology usability and patient satisfaction, (2) self-management of symptoms and patient-reported outcome–related indicators, (3) adherence, and (4) health-related quality of life.

Conclusions
A limited number of studies have investigated the use of mHealth technology in the postdischarge self-management of patients with HNC. The existing literature suggests that mHealth technology can effectively assist patients with HNC in self-management and postdischarge interventions. It plays an important role in addressing patients’ health information needs, reducing both their somatic and psychological burdens, and improving their overall quality of life. Future research should prioritize conducting additional high-quality RCTs to evaluate the usability and analyze the cost-effectiveness of mHealth technology.
Potential Implementers’ Perspectives on the Development and Implementation of an e–Mental Health Intervention for Caregivers of Adults With Chronic Kidney Disease: Qualitative Interview Study
Authors: Coumoundouros Chelsea , El Arab Rabie Adel , Farrand Paul , Hamilton Alexander , Sanderman Robbert , von Essen Louise , Woodford Joanne 
Published: October 2023

Background
e–Mental health interventions can improve access to mental health support for caregivers of people living with chronic kidney disease (CKD). However, implementation challenges often prevent effective interventions from being put into practice. To develop an e–mental health intervention for caregivers of people living with CKD that is optimized for future implementation, it is important to engage professionals that may endorse or deliver the intervention (ie, potential implementers) during intervention development.

Objective
This study aims to explore the perspectives of potential implementers working in kidney care, in mental health care, or at nonprofit organizations regarding the design and implementation of an e–mental health intervention for caregivers of people living with CKD.

Methods
Potential implementers (N=18) were recruited via National Health Service Trusts, email, and social media advertisements to participate in semistructured video interviews. Interview questions were informed by the Consolidated Framework for Implementation Research (CFIR). Data were analyzed using a deductive analysis approach using the CFIR, with inductive coding applied to relevant data not captured by the framework.

Results
A total of 29 generic categories, related to 17 CFIR constructs, were identified. The perceived fit between the intervention and implementation context (ie, existing service delivery models and work routines) and existing social networks among potential implementers were perceived as important factors in enhancing implementation potential. However, a need for capacity building among potential implementers to create systems to support the identification and referral of caregivers to an e–mental health intervention was identified. Equity concerns were raised regarding the intervention, highlighting the importance of incorporating an equity lens during intervention design to enhance accessibility and adoption.

Conclusions
Potential implementers provided valuable insights into key design and implementation factors to help inform the development of an e–mental health intervention for caregivers of people living with CKD. Incorporating their feedback can help ensure the intervention is acceptable and inform the selection of future implementation strategies to enhance the implementation potential of the intervention. Potential implementers should continue to be engaged throughout intervention development.
La robótica como medio de aprendizaje
Authors: Piñero Virué Rocío , Rodríguez González César Antonio , Reyes Rebollo Miguel María , Fernández Batanero José María 
Published: October 2023

Se presenta un estudio cuya finalidad es potenciar la atención del individuo a través de la robótica, en el ámbito personal y educativo. La muestra participante es un sujeto con necesidades específicas de apoyo educativo por trastorno de déficit de atención con gran motivación por la tecnología, en concreto, por la robótica. La metodología utilizada de corte experimental longitudinal permitió durante cuatro años evaluar las actitudes y aptitudes del sujeto en ambos ámbitos. Se utilizaron tres instrumentos de medida: cuestionario, entrevista y observación, para conseguir datos cuantitativos y cualitativos. Los resultados obtenidos fueron significativos: se observó un aumento en la capacidad de atención y concentración, adquisición de lateralidad, disponibilidad hacia las tareas grupales, aprendizaje reflexivo y comprensivo, felicidad, autoestima y mayor autonomía para la construcción de su propio aprendizaje. Se concluye con la corroboración de la robótica en la aportación de ventajas para el progreso del desarrollo integral del sujeto.
BUTTERFLY DIVERSITY IN THE FOREST OF BUKUM VILLAGE SIBOLANGIT DISTRICT DELI SERDANG REGENCY NORTH SUMATRA
Authors: Harahap Hamidah , Hutasuhut Melfa Aisyah , Idami Zahratul 
Published: October 2023

ABSTRAK Kupu-kupu adalah serangga yang aktif di siang hari yang memiliki peran penting sebagai polinator pada suatu ekosistem dan bioindikator pada suatu lingkungan. Penelitian dilakukan untuk mengetahui diversitas jenis, kemerataan jenis, dan perahu relatif jenis kupu-kupu di Hutan Desa Bukum Kecamatan Sibolangit Kabupaten Deli Serdang Sumatera Utara. Penelitian ini bersifat survey eksploratif dengan metode jelajah dan metode VES. Pengambilan sampel menggunakan jaring serangga, di pagi hari pukul 08.00-10.00 WIB dan sore hari 14.00-16.00 WIB. Terdapat 39 jenis kupu-kupu dari 6 famili dengan 473 individu. Indeks diversitas jenis kupu-kupu di Hutan Desa Bukum memiliki nilai rata-rata yaitu 2,93 yang termasuk dalam kategori sedang. Indeks kemerataan jenis kupu-kupu di Hutan Desa Bukum memiliki nilai rata-rata yaitu 0,79 yang termasuk dalam kategori tinggi. Indeks kelimpahan relatif jenis kupu-kupu di Hutan Desa Bukum yaitu jenis kupu-kupu Ypthima baldus dengan nilai rata-rata kelimpahan 18,60%. Berdasarkan analisis indeks diversitas, indeks kemerataan, dan indeks kelimpahan relatif jenis menunjukkan bahwa faktor abiotik atau kondisi lingkungan di Hutan Desa Bukum sesuai dengan siklus hidupnya kupu-kupu. Kata Kunci: Diversitas, Hutan Desa Bukum, Kemerataan, Kelimpahan relatif, Kupu-Kupu ABSTRACT Butterflies are insects who active in the day that have an important role as pollinators in an ecosystem and bioindicators in an environment. The study was conducted to determine species diversity, species evenness, and relative abundance of butterfly species in the Forest of Bukum Village Sibolangit District Deli Serdang Regency North Sumatra. This research is an exploratory survey using the roaming method and the VES method. Sampling using insect nets, in the morning at 08.00-10.00 WIB and in the afternoon 14.00-16.00 WIB. There are 39 species of butterflies from 6 families with 473 individuals. The butterfly species diversity index in the Forest of Bukum Village has an average value of 2.93 which is included in the medium category. The evenness index of butterfly species in the Forest of Bukum Village has an average value of 0.79 which is included in the high category. The relative abundance index of butterfly species in the Forest of Bukum Village is the Ypthima baldus butterfly species with an average abundance value of 18.60%. Based on the analysis of the diversity index, evenness index, and relative abundance index of species, it shows that abiotic factors or environmental conditions in the Forest of Bukum Village are in accordance with the life cycle of the butterfly. Keywords: Diversity, Bukum Village Forest, Equality, Relative Abundance, Butterfly
High-fat diets: you are what you eat....your extracellular vesicles too!
Authors: Rome Sophie , Tacconi Stefano 
Published: October 2023

Recent works indicate that the lipid composition of extracellular
vesicles (EVs) can modify their biological functions and their
incorporation into recipient cells. In particular high-fat diets affect
EV biogenesis, EV lipid composition, EV targeting and consequently the
cross-talk between tissues. This review connects different research
topics to show that a vicious circle is established during the
development of high-fat diet-induced obesity, connecting the alteration
of lipid metabolism, the composition of extracellular vesicles and the
spread of deleterious lipids between tissues, which participates in
NAFLD/NASH and diabetes development. According to the studies described
in this review, it is urgent to take an interest in this question as the
modulation of EV lipid composition could be an important factor to take
into account during the therapeutic management of patients suffering
from metabolic syndrome and related pathologies such as obesity and
diabetes. Furthermore, as lipid modification of EVs is a strategy
currently being tested to enable better integration into their target
tissue or cell, it is important to consider the impact of these lipid
modifications on the homeostasis of these targets.
KEY WORDS: extracellular vesicles, lipids, high-fat diets, NAFLD, NASH,
diabetes obesity, metabolic syndrome
RUNNING TITLE: Fat diets affect extracellular vesicle fate