bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for low phospholipid associated cholelithiasis among patients with post‐cholecystectomy biliary pain
Authors: Trinh Andrew , Tjandra Doug , Park Yeung‐Ae , Sood Siddharth , Thomson Benjamin , Speer Tony , Buchanan Daniel , Boussioutas Alex , Metz Andrew J. 
Published: February 2024

AbstractIntroductionLow phospholipid associated cholelithiasis (LPAC) is associated with variants of the adenosine triphosphate‐binding cassette subfamily B, member 4 (ABCB4) gene and is characterized by reduced phosphatidylcholine secretion into bile, impairing the formation of micelles and thus exposing bile ducts to toxic bile acids and increasing cholesterol saturation. LPAC is present in 1% of patients with gallstones and post‐cholecystectomy pain is common in this group. LPAC is an under‐appreciated cause of post‐cholecystectomy pain. The aim of this study is to assess a cohort of patients with post‐cholecystectomy pain to identify those with clinical features suggesting that further investigations for LPAC would be beneficial.MethodsA retrospective chart review was performed of the first 2 years of post‐operative follow‐up for all patients under 40 years of age undergoing cholecystectomy for symptomatic gallstones at a tertiary centre between January 2016 and December 2017.Results258 patients under the age of 40 underwent a cholecystectomy. 50 patients (19.4%) reported abdominal pain post‐cholecystectomy. Five patients (1.9%) fulfilled the criteria for suspected LPAC. Family history of gallstones was documented in 33 of 258 (12.8%) of cases. Obstetric history was obtained in 69 of 197 (35%) female patients. None of the five patients identified above who satisfied the criteria of LPAC had the diagnosis of LPAC considered by their treating clinicians.ConclusionLPAC is an under‐recognized cause of post‐cholecystectomy pain. Treatment can avoid long‐term symptoms and complications. Clinicians should take a family history and obstetric history to alert them to the diagnosis of LPAC.
The role of personal, relational, and collective self‐esteem in predicting acute salivary cortisol response and perceived stress
Authors: Tang Xinli , Hu Weiyu , Zhao Xiaolin , Liu Yadong , Ren Yipeng , Tang Zihan , Yang Juan 
Published: February 2024

AbstractPersonal self‐esteem (PSE) has been well recognized as a buffer against stress; however, the effects of other types of self‐esteem, such as relational self‐esteem (RSE) and collective self‐esteem (CSE), on stress have not been adequately explored. This study investigated the roles of PSE, RSE, and CSE in reducing stress response. The Rosenberg, Relational, and Collective Self‐Esteem Scales were adopted to assess PSE, RSE, and CSE, respectively. Participants underwent an acute social stress paradigm, and their acute stress response was assessed using subjective stress reports and salivary cortisol levels. Chronic stress level was estimated using the Perceived Stress Scale and hair cortisol concentration. The results showed that PSE was negatively correlated with salivary cortisol response during acute social stress; however, no significant associations were found between any type of self‐esteem and subjective stress reports. For chronic stress, all types of self‐esteem were negatively associated with perceived stress level, but not with hair cortisol concentration. Further hierarchical regression analyses suggested that only PSE negatively predicted acute salivary cortisol response and perceived stress level. Overall, the findings suggest the essential role of PSE in predicting acute salivary cortisol responses and perceived stress.
Understanding the impact of children's and young people's self‐harm on parental well‐being: a systematic literature review of qualitative and quantitative findings
Authors: Martin Faith , Ferrey Anne , Hobbs Laura , Lascelles Karen , van Even Suzanne , Oliver Thomas 
Published: February 2024

BackgroundSelf‐harm in children and young people is increasing. Parents are vital in supporting young people; however, parents may experience distress linked to the self‐harm. Previous reviews have highlighted the emotional impact and need for information and support, however, have not elucidated the relationships between these themes, nor examined the quantitative data examining parents' well‐being.MethodsWe conducted a mixed methods review, with qualitative meta‐synthesis focusing on links between themes and quantitative synthesis of parental well‐being findings, including pooled means. PsycInfo, Medline, EMBASE, AMED, CINHAL and Web of Science were searched to identify relevant records. References of included studies were also searched. Every abstract was screened by two authors. Data were extracted by one author and checked by another.ResultsWe identified 39 reports of 32 studies: 16 with qualitative data and 17 with quantitative data (one had both). Qualitative findings showed how parents' emotions were associated to their knowledge and beliefs about self‐harm. Parents' emotions often evidenced the need to self‐care, but emotions of guilt reduced engagement in self‐care. How parents supported their young person was linked to their knowledge, and the management of their own emotions, and influenced if they could engage in self‐care. Quantitative findings were mixed, however suggested poor general mental health amongst these parents.ConclusionsFurther good quality quantitative studies are needed, with measurement of psychological mechanisms that may underpin parental distress. Current evidence supports peer‐support and interventions that go beyond information provision to address the connected factors of knowledge, emotion, self‐care, and parenting behaviours.
Current understanding of subclinical diabetic retinopathy informed by histology and high‐resolution in vivo imaging
Authors: Hein Martin , Qambari Hassanain , An Dong , Balaratnasingam Chandrakumar 
Published: February 2024

AbstractThe escalating incidence of diabetes mellitus has amplified the global impact of diabetic retinopathy. There are known structural and functional changes in the diabetic retina that precede the fundus photography abnormalities which currently are used to diagnose clinical diabetic retinopathy. Understanding these subclinical alterations is important for effective disease management. Histology and high‐resolution clinical imaging reveal that the entire neurovascular unit, comprised of retinal vasculature, neurons and glial cells, is affected in subclinical disease. Early functional manifestations are seen in the form of blood flow and electroretinography disturbances. Structurally, there are alterations in the cellular components of vasculature, glia and the neuronal network. On clinical imaging, changes to vessel density and thickness of neuronal layers are observed. How these subclinical disturbances interact and ultimately manifest as clinical disease remains elusive. However, this knowledge reveals potential early therapeutic targets and the need for imaging modalities that can detect subclinical changes in a clinical setting.
Spread management priorities to limit emerald ash borer (Agrilus planipennis) impacts on United States street trees
Authors: Hudgins Emma J. , Hanson Jeffrey O. , MacQuarrie Chris J. K. , Yemshanov Denys , Baker Christopher M. , Chadès Iadine , Holden Matthew H. , McDonald‐Madden Eve , Bennett Joseph R. 
Published: February 2024

AbstractThe invasive emerald ash borer (Agrilus planipennis) causes damage to street trees which is estimated to reach US$ 900 million over the next 30 years. Although millions of dollars are spent annually to control this species, spatiotemporal management plans are often based on rules of thumb that ignore future pest dispersal. Here, we reveal an optimal management strategy to protect urban trees in North America from A. planipennis. To achieve this, we embedded a pest dispersal model within a mixed integer programming framework. We discovered that optimized strategies consistently outperformed those based on rules of thumb, potentially resulting in the protection of an additional nearly 1 million street trees and savings of $ 629 million. Critically, the best management strategies always relied on quarantines and biological control (constituting 98–99% and 1–2% of the project budget, respectively), in contrast with current practices, where federal spending has been diverted to biological control. Our findings serve to inform future pest control efforts and can help protect many more trees from this invasive species.
Biomarker and pharmacodynamic activity of the transforming growth factor‐beta (TGFβ) inhibitor SAR439459 as monotherapy and in combination with cemiplimab in a phase I clinical study in patients with advanced solid tumors
Authors: Robbrecht Debbie , Grob Jean‐Jacques , Bechter Oliver , Simonelli Matteo , Doger Bernard , Borbath Ivan , Butler Marcus O. , Cheng Tina , Romano Patricia Martin , Pons‐Tostivint Elvire , Di Nicola Massimo , Curigliano Giuseppe , Ryu Min‐Hee , Rodriguez‐Vida Alejo , Schadendorf Dirk , Garralda Elena , Abbadessa Giovanni , Demers Brigitte , Amrate Amele , Wang Hong , Lee Joon Sang , Pomponio Robert , Wang Rui 
Published: February 2024

AbstractSAR439459, a ‘second‐generation’ human anti‐transforming growth factor‐beta (TGFβ) monoclonal antibody, inhibits all TGFβ isoforms and improves the antitumor activity of anti‐programmed cell death protein‐1 therapeutics. This study reports the pharmacodynamics (PD) and biomarker results from phase I/Ib first‐in‐human study of SAR439459 ± cemiplimab in patients with advanced solid tumors (NCT03192345). In dose‐escalation phase (Part 1), SAR439459 was administered intravenously at increasing doses either every 2 weeks (Q2W) or every 3 weeks (Q3W) with cemiplimab IV at 3 mg/kg Q2W or 350 mg Q3W, respectively, in patients with advanced solid tumors. In dose‐expansion phase (Part 2), patients with melanoma received SAR439459 IV Q3W at preliminary recommended phase II dose (pRP2D) of 22.5/7.5 mg/kg or at 22.5 mg/kg with cemiplimab 350 mg IV Q3W. Tumor biopsy and peripheral blood samples were collected for exploratory biomarker analyses to assess target engagement and PD, and results were correlated with patients' clinical parameters. SAR439459 ± cemiplimab showed decreased plasma and tissue TGFβ, downregulation of TGFβ‐pathway activation signature, modulation of peripheral natural killer (NK) and T cell expansion, proliferation, and increased secretion of CXCL10. Conversion of tumor tissue samples from ‘immune‐excluded’ to ‘immune‐infiltrated’ phenotype in a representative patient with melanoma SAR439459 22.5 mg/kg with cemiplimab was observed. In paired tumor and plasma, active and total TGFβ1 was more consistently elevated followed by TGFβ2, whereas TGFβ3 was only measurable (lower limit of quantitation ≥2.68 pg/mg) in tumors. SAR439459 ± cemiplimab showed expected peripheral PD effects and TGFβ alteration. However, further studies are needed to identify biomarkers of response.
Das kutane Mikrobiom bei Hautkrebs – Eine systematische Übersicht
Authors: Ding Ruojun , Lian ShengYang Bertrand , Tam Yew Chong , Oh Choon Chiat 
Published: February 2024

ZusammenfassungDie Hautkrebs‐Inzidenz ist über die vergangene halbe Dekade weltweit gestiegen und mit signifikanter Morbidität und Mortalität assoziiert. Jüngste Fortschritte in der molekularen Diagnostik ermöglichen ein besseres Verständnis von Mikrobiom‐Veränderungen bei diesen Erkrankungen. Allerdings ist die Literatur zum kutanen Mikrobiom bei Hautkrebs nach wie vor heterogen und spärlich. Wir führten eine systematische Überprüfung durch, um die bestehende Literatur sowie ihren Nutzen bezüglich mikrobiombasierter Biomarker zu evaluieren. Die Datenbanken (PubMed, Medline, EMBASE, GoogleScholar) wurden zwischen Juni und Juli 2022 in Übereinstimmung mit den PRISMA‐Richtlinien gesichtet.Insgesamt wurden 1.543 Artikel ermittelt, von denen 16 in die Übersicht eingeschlossen wurden (11 Artikel zu epithelialen Hauttumoren und 5 Artikel zu Melanomen). Bei Plattenepithelkarzinomen (PEKs) und aktinischer Keratose (AK) wird im Vergleich zu gesunder Haut eine erhöhte Prävalenz von Staphylococcus (S.) aureus bei gleichzeitigem Rückgang der kommensalen Organismen festgestellt. Das Mikrobiom des Melanoms scheint sich zwar von dem der gesunden Haut zu unterscheiden, doch stehen nur wenige Daten für aussagekräftige Schlussfolgerungen zur Verfügung.Die vorliegende Übersicht fasst die aktuellen Erkenntnisse zum Mikrobiom bei epithelialem Hautkrebs und Melanom zusammen. Sie zeigt, dass sich das Mikrobiom bei diesen Erkrankungen von dem gesunder Haut unterscheidet und dass an dieser Dysbiose sowohl pathogene als auch kommensale Organismen beteiligt sind.
Defending (perceptual) attitudes
Authors: Martinis Valentina 
Published: February 2024

AbstractIn this paper, I defend a tripartite metaphysics of intentional mental states, according to which mental states are divided into subject, content, and attitude, against recent attempts at eliminating the attitude component (e.g., Montague, Oxford studies in philosophy of mind, 2022, 2, Oxford University Press). I suggest that a metaphysics composed of only subject and content cannot account for (a) multisensory perceptual experiences and (b) phenomenological differences between episodes of perception and imagination. Finally, I suggest that some of the motivations behind the rejection of the attitude component can be accommodated within the tripartite framework.
Sentiment and the cross‐section of expected stock returns
Authors: Jacoby Gady , Liao Chi , Lin Nanying , Lu Lei 
Published: February 2024

AbstractThe asset pricing Literature suggests market sentiment is a state variable. This study shows that market sentiment is positively priced at the cross‐section of stock returns, conditional on aggregate investors’ sentiment. We estimate individual stock sentiment beta and find that, following low‐sentiment periods, stocks in the highest sentiment beta quintile generate a 0.74% higher monthly return than stocks in the lowest sentiment beta quintile. However, this return spread is insignificant following medium‐ or high‐sentiment periods. This finding is consistent with the argument that overpricing following high‐sentiment periods is more prevalent than underpricing following low‐sentiment periods due to short‐sale constraints.
Utilizing treated wastewater for pasture irrigation: Effects on productivity, plant community structure and soil properties
Authors: Lavi Renana , Bar‐Massada Avi , Dovrat Guy 
Published: February 2024

AbstractSurplus wastewater accumulates in winter and requires a discharging solution. In our study we examined the effects of using treated wastewater (TWW) as supplemental pasture irrigation in winter. To test the effect of TWW irrigation on the vegetation and soil, 10 grazing prevention exclosures were established at Ramat‐Hanadiv Park, Israel, with half of them irrigated with TWW. Soil and vegetation were sampled during 2 years of irrigation and 1 year after cessation of irrigation. Vegetation composition, species richness, and productivity were sampled at the peak of the growing season and various indices of herbage quality were measured. Our results show that irrigation with wastewater increased herbage production by an average of 38% and total pasture protein production by 9% relative to the control subplots. Conversely, TWW irrigation decreased plant protein content while increasing herbage fibre content and lowering its digestibility. Over a period of 2 years, species richness decreased in the irrigated subplots. Most of the soil indices examined were not affected by irrigation, but in the irrigation subplots, sodium values and the sodium adsorption‐ratio were higher than in areas without irrigation. Additional resources in winter enabled the plants to grow rapidly and increased interplant competition. Changes in vegetation composition were revealed through functional group reshuffling and species richness decline. The results of our study show that wastewater irrigation causes an increase in productivity but a decrease in forage quality. At the pastoral system level, the significant increase in productivity leads to increased availability of protein and herbage for animals.
Travailler moins? Revue systématique des préférences et décisions en matière de temps de travail
Authors: ANTAL Miklós , LEHMANN Benedikt , GUIMARAES Thiago , HALMOS Alexandra , LUKÁCS Bence 
Published: February 2024

RésuméMalgré les retombées économiques, sociales et environnementales de l'évolution du temps de travail, les études sur les préférences en la matière sont dispersées entre diverses disciplines et disséminées dans de multiples revues. Dans cette revue systématique de la littérature fondée sur 173 articles, il est démontré que les études existantes concernent un petit nombre de pays de l'OCDE, portent surtout sur les professions médicales et font essentiellement appel à des données d'enquête et à des méthodes statistiques. Les résultats les plus clairs et les plus homogènes ont trait à l'influence du genre, des obligations en matière de garde des enfants et du temps de travail actuel, tandis que les normes et la formation des préférences demeurent mal comprises. Davantage de travaux qualitatifs sont indispensables pour déterminer comment faire progresser la réduction du temps de travail.
¿Queremos trabajar menos horas? Revisión sistemática de los resultados y preferencias de tiempo de trabajo
Authors: ANTAL Miklós , LEHMANN Benedikt , GUIMARAES Thiago , HALMOS Alexandra , LUKÁCS Bence 
Published: February 2024

ResumenLa variación del tiempo de trabajo tiene importantes consecuencias económicas, sociales y ambientales, pero los estudios sobre las preferencias de los trabajadores están fragmentados entre diversas disciplinas y revistas. Para superar este escollo, se presenta una revisión sistemática de 173 estudios. Los resultados y la inadecuación del tiempo de trabajo se han investigado mayoritariamente en países de la OCDE, con datos de encuestas y métodos estadísticos. Los hallazgos más robustos se refieren al género, las responsabilidades familiares y las horas de trabajo actuales. Las ocupaciones más estudiadas son las del sector sanitario. Un corpus de investigaciones cualitativas que esclarezcan la formación de usos y preferencias ayudará a comprender cómo se propagan los modelos de reducción del tiempo de trabajo.
Spatiotemporal variability of fall daily maximum flows in southern Quebec (Canada) from 1930 to 2018
Authors: Assani Ali A. 
Published: February 2024

AbstractQuebec is experiencing a significant increase in summer and fall temperatures and rainfall. This study compares the spatiotemporal variability of maximum daily flows generated by rainfall during the fall season (September–December) in relation to this climatic change and physiographic and land use factors. Analysis of the spatial variability of these maximum flows measured from 1930 to 2018 in 17 watersheds revealed that the magnitude of flows is approximately twice as low on the north shore as it is on the south shore south of 47° N. This difference is explained by three main factors: wetlands (negative correlation) and agricultural (positive correlation) surface area, and summer–fall total precipitation (positive correlation). As for the temporal variability of flows, the different Mann–Kendall statistical tests showed a significant increase in flows due to increased rainfall. The increase of flows was more widespread on the north shore than on the south because the storage capacity of wetlands and other water bodies does not change over time to store excess rainfall. On the south shore, the increase in flows over time is limited due to the significant reduction in agricultural areas since the modernization of agriculture. This reduction favored infiltration to the detriment of runoff.
Entheseal variation and locomotor behavior during growth
Authors: Mameli Davide , Pietrobelli Annalisa , Sorrentino Rita , Nicolosi Teresa , Mariotti Valentina , Belcastro Maria Giovanna 
Published: February 2024

AbstractEntheses are acknowledged as skeletal markers capable of revealing several biological and behavioral aspects of past individuals and populations. However, entheseal changes (ECs) of juvenile individuals have not yet been studied with a systematic approach. This contribution aims at investigating the morphological changes occurring at the femoral insertion of the gluteus maximus and tibial origin of the soleus muscles to highlight a potential link between the morphological features of those entheses and skeletal maturity in relation to sex, age, and locomotor developmental patterns. The sample consisted of 119 skeletons (age‐at‐death: 0–30 years) belonging to the Documented Human Skeletal Collection of the Certosa Cemetery (Bologna, Italy). The entheseal variation during the last stages of skeletal maturation in young adults was assessed using existing recording standards. A recording protocol for each enthesis was developed for immature individuals to subdivide the morphological variability into discrete categories. Univariate, bivariate, and multivariate statistical analyses were performed to investigate the variation of entheseal morphologies and measurements in relation to bone metrics, degree of epiphyseal closure, sex, age, and locomotor developmental patterns. A statistically significant relationship was observed between ECs morphological patterns and age for both entheses, while sexual differences were negligible. A relationship between ECs morphological pattern and locomotor milestones emerged only for the gluteus maximus. Even though further testing is needed on other documented skeletal collections, our protocol could be usefully applied in forensic and archaeological fields and serving as important reference for evolutionary investigations.
Factors Relating to Kanji Reading Accuracy in Kun‐readings: An Item‐Level Analysis
Authors: Kakihana Shinichiro 
Published: February 2024

AbstractThis study sought to obtain comprehensive data on the difficulty level of kun‐reading (native Japanese reading) of Japanese kanji (Chinese characters adapted for Japanese) learned in junior high and high school. Drawing from an item‐based analysis, it explored the word variables related to the difficulty level of kun‐reading. A reading test comprising 645 kun‐readings of common kanji learned in junior high and high school was administered to 123 university students. Tobit regressions were conducted for the total, okurigana (phonetic kana letters suffix written after kanji), and single kanji items, using the word variables as independent variables and the reading accuracy as the dependent variable. Significant positive contributions were observed for imageability and word frequency for all item categories, kun‐reading ratio for the single kanji items, and okurigana ratio for the total items. A significant negative contribution was observed for okurigana neighborhood size for the okurigana items. The results highlighted the need for education focusing on the meanings of kanji characters, and for a language policy for the use of the okurigana.