bluuebunny/crossref_metadata_2025_split huggingface dataset:
Writing and Unsettlement: Narratives of Migration in Bekim Sejranović and Hassan Blasim
Authors: Majstorovic Gorica 
Published: November 2023

Abstract
The present article focuses on unsettling language and place in texts by two contemporary migrant writers, Hassan Blasim (Iraq-Finland) and Bekim Sejranović (Bosnia-Norway). They fled war-torn areas while leaving a remarkable textual trace in Sejranović’s Diary of a Nomad (2017) and Blasim’s “The Nightmares of Carlos Fuentes” (2014). This article addresses the ways in which these authors engage migrant multilingualism and question the ethics of exploiting migrant lives as material for media consumption. It argues that their writings are politically engaged counternarratives that are boundary-crossing because they problematize disciplinary, linguistic, and narrative borderlines.
“Le fransè ke chparl ègzist”: Translanguaging in the Work of Katalin Molnár
Authors: Pshevorska Liana 
Published: November 2023

Abstract
The works of Franco-Hungarian Katalin Molnár (1951–) stand in stark contrast to most modern-day translingual writing in France. Inspired by her avant-garde aesthetics and migration experience, Molnár radically defamiliarizes French through Hungarian syntax, phonetic orthography, and visual modalities. This article examines her work through the critical lens of translanguaging—a practice that draws on the speaker’s internal linguistic inventory without differentiating between external, socio-politically defined individual languages (Otheguy et al.). Through translanguaging, Molnár subverts a common translingual practice of thematizing a language-learning path into French. Instead of witnessing her linguistic journey from a safe distance, francophone readers are placed into a language experience of their own, which invites empathy and a change of perspective. Molnár’s visual and linguistic defamiliarization of French moves her texts beyond the dichotomous native/foreign paradigm, inducing readers to participate in the co-creation of a multimodal language that melds the author’s ethical and aesthetic concerns.
An Assessment of Orthodontists’ Perception About Efficiency of Various Tooth Movements Carried Out Using Clear Aligner Therapy
Authors: Chawla Shilpa , Deshmukh Shailesh , Bhosale Veera 
Published: November 2023

Background With orthodontic patient demographics expanding to involve more adults, the demand for esthetic appliances is greater and orthodontists are keen on offering their patients more discreet and even invisible options. Clear aligners are a very viable option which offers all this, and it is noteworthy that more and more orthodontists in India are practicing the craft. Keeping this vision in mind, and the fact that aligners are revolutionary and here to stay, this study was conducted to assess the efficiency of various tooth movements carried out with clear aligner therapy as compared to traditional orthodontic treatment. Aim This questionnaire-based survey aimed to analyze and assess the orthodontists’ perception and experience of various tooth movements carried out with clear aligner in their routine clinical practice in India. Methodology A cross-sectional study was conducted by sending out a questionnaire on a virtual platform. It was approved by the Ethical Committee of the Dental Institute it was carried out in (Ref no: SDCH/IEC/OUT 2021/13). A sample size of 205 participants within the age group of 27–59 years was taken. The participants comprised of orthodontists practicing in various parts of India. A questionnaire, comprising of 22 closed-ended questions, was created on Google forms and circulated to participants using various social media platforms. The data of responses of participants were analyzed and evaluated with the help of chi-square test and p values were interpreted for the significance of responses. Results This survey analyzed the experience of orthodontists with respect to the various tooth movements carried out with clear aligners. There were mixed responses, but most of them suggested the aligners to be either same in effectiveness or poorer than the fixed appliances in carrying out various tooth movements. Conclusion This questionnaire-based survey helped in analyzing the orthodontists’ perception on the use of clear aligners in their routine clinical practice in India. It most importantly helped in assessing various kinds of tooth movements achievable with clear aligners. It also helped in getting an opinion on the movements presently not possible with aligners alone. This study clearly suggests that the general perception amongst the orthodontists is that more advancement is needed as far as aligners are concerned before they become competent enough to deal with various tooth movements easily achievable with fixed appliances.
Sexual satisfaction and vaccine application in health professionals in the COVID-19 pandemic
Authors: Yığman Metin , Yığman Fatih , Özcan Cihat , Aytekin Cuma 
Published: November 2023

Introduction: The negative effects of the COVID-19 pandemic on sexual satisfaction have been emphasized in many studies. However, there is not much information about the effects of the COVID-19 pandemic on the sexual satisfaction of healthcare professionals. In addition, it is not known exactly how vaccination application affects sexual satisfaction. Therefore, in this study, we aimed to evaluate whether the sexual satisfaction of male health personnel would change with vaccination. Materials and methods: One hundred and two unvaccinated and 95 vaccinated male healthcare professionals participated in this study. The COVID-19 Phobia Scale (C19P-S) and The New Sexual Satisfaction Scale (NSSS) were administered to the participants. Results: We did not detect any difference in sexual satisfaction according to vaccine administration. However, we found significant relationships between COVID-19 anxiety and sexual satisfaction. On the other hand, age, fear of COVID-19, and previous COVID-19 infection story were predictive factors on sexual satisfaction. Conclusion: The effects of the COVID-19 pandemic on sexual satisfaction are multifaceted. Our findings indicate that fear of COVID-19, rather than vaccination, determines sexual satisfaction.
Identifying tumor markers-stratified subtypes (CA-125/CA19-9/carcinoembryonic antigen) in cervical adenocarcinoma
Authors: Zhang Zongkai , Li Yin , Wu Ying , Bi Rui , Wu Xiaohua , Ke Guihao , Zhu Jun 
Published: November 2023

Objective There is a lack of research evaluating the effect of tumor markers for prognosis in cervical adenocarcinoma. We aimed to develop and validate a preoperative tumor-marker-based model including clinicopathological factors to clarify the prognostic value of endocervical adenocarcinoma. Methods A total of 572 patients with cervical adenocarcinoma who were staged at the International Federation of Gynecology and Obstetrics (FIGO) IA–IIA were reviewed retrospectively. Preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA)-125 and CA19-9 levels were measured. The survival and recurrence patterns were analyzed according to the tumor-marker-related stratification. The predictive values of biomarkers and clinical variables were assessed with Cox regression and competing risk models. Results Patients with elevated preoperative tumor markers had evidently poor overall survival and recurrence-free survival. The triple-elevated tumor marker (TETM) subgroup had the worst overall survival and progression-free survival than the triple-negative tumor marker (TNTM) subgroup and the single-elevated tumor marker (SETM) subgroup. The most important predictors for overall survival were elevated tumor markers, FIGO-stage, tumor differentiation, lymphovascular space invasion (LVSI) and lymph nodes metastasis. The most important predictors for recurrence-free survival were elevated tumor markers, FIGO-stage, tumor differentiation, LVSI and deep stromal invasion. Stratified analysis showed that elevated CA-125 and CA19-9 were significantly associated with postoperative distant metastasis. A decision curve analysis confirmed that a combination of tumor markers as predictors significantly outperformed the other common predictors used (FIGO-stage, intermediate and high-risk factors, tumor differentiation, lymph nodes). Conclusions Elevated preoperative serum CEA, CA-125, and CA19-9 levels exhibited poor overall survival and recurrence-free survival in cervical adenocarcinoma patients. Combined preoperative serum CA-125 and CA19-9 independently predicted distant metastasis in patients with endocervical adenocarcinoma.
Decrease of over-elevation in adduction after surgery of medial rectus muscles in partially refractive accommodative esotropia
Authors: Acar Zeynep , Altintas Ozgul , Ozkan Berna , Yılmaz Tuğan Büşra , Turkseven Kumral Esra , Ercalik Yesim 
Published: November 2023

Significance The course of over-elevation in adduction after strabismus surgery has been evaluated in a small number of research in the literature, we believe our study is the first to report the results in a specific group of esotropia (ET) patients. Aim To report the course of postoperative over-elevation in adduction in patients who underwent surgery for horizontal deviation on the medial recti in partially accommodative ET. Methods The medical charts of patients who had partially accommodative ET with over-elevation in adduction were reviewed retrospectively. A scale from −4 to +4 was used to grade the oblique muscle function. Among these, 17 patients who were operated solely on the horizontal rectus muscles were identified. The primary outcome measure was the degree of improvement in over-elevation in adduction after medial rectus surgery. Results Nine (52.9%) of the 17 patients (mean age: 5.18 ± 2.24 months) were males and 8 (47.1%) were females. The mean follow-up period was 17.06 ± 15.32 months. Overall, 15 patients (88.2%) achieved surgical success. The mean inferior oblique overaction was found 1.44 ± 0.56 preoperatively and the final postoperative mean inferior oblique overaction was 0.53 ± 0.51 ( P = 0.001). Postoperative over-elevation in adduction after 3 months was significantly decreased compared to the preoperative value ( P = 0.003, P = 0.001, P = 0.001 at 3rd and 6th months and final visits respectively). Conclusion Over-elevation in adduction accompanying partially refractive accommodative ET seems to regress after medial rectus weakening surgery. This finding should be considered in the presurgical evaluation of these patients.
Characterising hospitalisation risk for chronic obstructive pulmonary disease exacerbations: Bedside and outpatient clinic assessments of easily measured variables
Authors: Heerema Joshua , Hug Sarah , Bear Natasha , Hill Kylie 
Published: November 2023

Objective To identify the characteristics of people with chronic obstructive pulmonary disease (COPD) who require hospitalisation for exacerbations. Methods People with COPD were recruited either during hospitalisation or from out-patient respiratory medicine clinics. Hospital admissions were tracked throughout the 5-months recruitment period. For participants who were admitted, hospital readmissions were tracked for at least 30 days following discharge. Participants were grouped as either needing; (i) no hospital admission during the study period (no admission; ø-A), (ii) one or more hospital admissions during the study period but no readmission within 30 days of discharge (no rapid readmission; ø-RR) or (iii) one or more hospital admissions with a readmission within 30 days of discharge (rapid readmission; RR). Results Compared with the ø-A group ( n=211), factors that independently increased the risk of ø-RR ( n=146) and/or RR ( n=57) group membership were being aged >60 years, identifying as an Indigenous person (relative risk ratio, 95% confidence interval 7.8 [1.8 to 34.0]) and the use of a support person or community service for activities of daily living (1.5 [1.0 to 2.4]. A body mass index ≥25 kg/m2 was protective. Conclusions Variables recorded at the bedside or in clinic provided information on hospitalisation risk.
Emergency and Compassionate Use of a Novel Ascending Endograft for Ascending and Arch Aortic Pathology
Authors: Patel Himanshu J. , Preventza Ourania , Roselli Eric E. , Atkins Marvin D. , Brinkman William , Coselli Joseph , Desai Nimesh , Estrera Anthony , Fleischman Fernando , Taylor Bradley S. , Reardon Michael J. 
Published: November 2023

Purpose: Patients with complicated ascending aortic pathology, including patients with acute type A aortic dissection may be at extreme risk for open repair. Thoracic endovascular aortic repair (TEVAR), infrequently used for the ascending aorta, may be considered an alternative in this setting. We describe early results for emergency and compassionate (E&C) use of a novel endograft, specifically designed for use to treat pathology of the ascending aorta. Materials and Methods: This case series evaluated 19 patients (mean age, 68.84±13.12 years; 57.9% female) treated with ascending TEVAR for acute and chronic acute (4), subacute (1), or chronic (1) aortic dissection or pseudoaneurysm (13). Six of the 19 patients (31.5%) were treated under compassionate use and 13 patients (68.4%) were treated under the emergency use exemption. Ten patients (52.6%) received additional devices to extend treatment into the arch and descending aorta. Results: Device delivery was achieved in all patients (100%). Thirty-day mortality and stroke occurred in 3 patients (15.8%) and in 1 patient (5.3%), respectively. In 1 patient (5.3%), with an Unanticipated Adverse Device Event, the aorta ruptured when the endograft eroded into the adventitial portion of dissection site at the posterior aspect of the ascending wall. Devices were explanted in 2 patients (10.5%), 353 and 610 days after the index procedure, respectively. Six patients had endoleaks (31.6%), including type I (n=2, 10.5%), type II endoleaks (n=3, 15.8%), and indeterminate endoleak (n=1, 5.3%). Conclusions: Delivery and deployment of a novel ascending thoracic stent graft with or without an additional branched arch extension is feasible in patients with complex anatomy and pathology, including acute aortic dissection and pseudoaneurysm. Additional experience with this novel device will further refine the patient population most suitable for endovascular ascending aortic repair for these pathologies. Clinical Impact This study describes a novel stent graft specifically designed for treatment of ascending aortic pathology, including acute type A dissection. The patients described in this series constituted a group outside the formal US FDA sponsored clinical trial, and were those accepted as part of an emergency and compassionate use basis.
Physical Examination Versus Ultrasonography for Detection of Ulnar Nerve Subluxation in Professional Baseball Pitchers
Authors: Looney Austin M. , Day Hannah K. , Reddy Manoj P. , Paul Ryan W. , Nazarian Levon N. , Cohen Steven B. 
Published: November 2023

Background: Despite the importance of accurately detecting ulnar nerve subluxation in vulnerable athletes, few studies have compared the performance of physical examination and ultrasound in this population. Purpose/Hypothesis: The purpose of this study was to compare the diagnostic validity of physical examination versus ultrasound in detecting ulnar nerve subluxation at the cubital tunnel of the elbow in professional baseball pitchers. It was hypothesized that ultrasound would more sensitively detect ulnar nerve subluxation. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Physical and sonographic examinations for ulnar nerve subluxation were performed on 186 elbows of 95 consecutive male professional baseball pitchers (age, 17-30 years) as a routine part of their spring training assessments. Provocative maneuvers consisting of the Tinel and elbow flexion-compression tests were evaluated over the cubital tunnel. The validity of physical examination for detecting ulnar nerve subluxation at the elbow was determined using ultrasonographic examination for comparison. Results: Ulnar nerve subluxation was detected by physical examination in 58 (31.2%) elbows and by ultrasonography in 61 (32.8%) elbows. Of the 58 elbows with positive physical examination, 47 were positive on ultrasound. Using a positive ultrasound as a reference, the accuracy of the physical examination was 86.6%, with 77% sensitivity and 91.2% specificity. The positive and negative predictive values of physical examination were 81% and 89.1%, respectively. There was no relationship between nerve instability and positive provocative tests overall, in dominant versus nondominant arms, or in right versus left arms ( P > .05 for all). Conclusion: Physical examination had moderate sensitivity and high specificity for detecting ulnar nerve subluxation at the cubital tunnel of the elbow when compared with ultrasound. These findings suggest that when detecting the presence of a subluxating ulnar nerve is most important, it may be advisable to obtain an ultrasound evaluation instead of relying on a physical examination; however, physical examination alone may be appropriate for ruling out subluxation.
One-year safety and efficacy of mitapivat in sickle cell disease: follow-up results of a phase 2, open-label study
Authors: van Dijk Myrthe J. , Rab Minke A. E. , van Oirschot Brigitte A. , Bos Jennifer , Derichs Cleo , Rijneveld Anita W. , Cnossen Marjon H. , Nur Erfan , Biemond Bart J. , Bartels Marije , Jans Judith J. M. , van Solinge Wouter W. , Schutgens Roger E. G. , van Wijk Richard , van Beers Eduard J. 
Published: November 2023

Abstract
Targeting the primary pathogenic event of sickle cell disease (SCD), the polymerization of sickle hemoglobin (HbS), may prevent downstream clinical events. Mitapivat, an oral pyruvate kinase (PK) activator, has therapeutic potential by increasing adenosine triphosphate (ATP) and decreasing 2,3-diphosphoglycerate (2,3-DPG), a glycolytic red blood cell (RBC) intermediate. In the previously reported 8-week dose-finding period of this phase 2, investigator-initiated, open-label study, mitapivat was well tolerated and showed efficacy in SCD. Here, the 1-year fixed-dose extension period is reported in which 9 of 10 included patients (90%) aged ≥16 years with SCD (HbSS, HbS/β0, or HbS/β+) continued with mitapivat. Mostly mild treatment-emergent adverse events (AEs) (most commonly, transaminase increase and headache) were still reported. Apart from the reported nontreatment-related serious AE (SAE) of a urinary tract infection in the dose-finding period, 1 nontreatment-related SAE occurred in the fixed-dose extension period in a patient who died of massive pulmonary embolism due to COVID-19. Importantly, sustained improvement in Hb level (mean increase, 1.1 ± 0.7 g/dL; P = .0014) was seen, which was accompanied by decreases in markers of hemolysis. In addition, the annualized rate of vaso-occlusive events reduced significantly from a historic baseline of 1.33 ± 1.32 to 0.64 ± 0.87 (P = .0489) when combining the dose-finding period and fixed-dose extension period. Cellularly, the ATP:2,3-DPG ratio and Hb-oxygen affinity significantly increased and RBC sickling (point of sickling) nonsignificantly reduced. Overall, this study demonstrated 1-year safety and efficacy of treatment with mitapivat in SCD, supporting further evaluation in ongoing phase 2/3 study (RISE UP, NCT05031780). This trial was registered at https://www.clinicaltrialsregister.eu/ as NL8517 and EudraCT 2019-003438-18.
Age of diagnosis for children with chromosome 15q syndromes
Authors: Wheeler Anne C. , Gantz Marie G. , Cope Heidi , Strong Theresa V. , Bohonowych Jessica E. , Moore Amanda , Vogel-Farley Vanessa 
Published: November 2023

Abstract
Objective
The objective of this study was to identify the age of diagnosis for children with one of three neurogenetic conditions resulting from changes in chromosome 15 (Angelman syndrome [AS], Prader-Willi syndrome [PWS], and duplication 15q syndrome [Dup15q]).

Methods
Data about the diagnostic process for each condition were contributed by the advocacy organizations. Median and interquartile ranges were calculated for each condition by molecular subtype and year. Comparison tests were run to explore group differences.

Results
The median age of diagnosis was 1.8 years for both AS and Dup15q. PWS was diagnosed significantly younger at a median age of 1 month. Deletion subtypes for both PWS and AS were diagnosed earlier than nondeletion subtypes, and children with isodicentric duplications in Dup15q were diagnosed earlier than those with interstitial duplications.

Conclusion
Understanding variability in the age of diagnosis for chromosome 15 disorders is an important step in reducing the diagnostic odyssey and improving access to interventions for these populations. Results from this study provide a baseline by which to evaluate efforts to reduce the age of diagnosis for individuals with these conditions.
Disentangling the dynamics of energy allocation to develop a proxy for robustness of fattening pigs
Authors: Lenoir Guillaume , Flatres-Grall Loïc , Muñoz-Tamayo Rafael , David Ingrid , Friggens Nicolas C. 
Published: November 2023

Abstract
Background
There is a growing need to improve robustness of fattening pigs, but this trait is difficult to phenotype. Our first objective was to develop a proxy for robustness of fattening pigs by modelling the longitudinal energy allocation coefficient to growth, with the resulting environmental variance of this allocation coefficient considered as a proxy for robustness. The second objective was to estimate its genetic parameters and correlations with traits under selection and with phenotypes that are routinely collected. In total, 5848 pigs from a Pietrain NN paternal line were tested at the AXIOM boar testing station (Azay-sur-Indre, France) from 2015 to 2022. This farm is equipped with an automatic feeding system that records individual weight and feed intake at each visit. We used a dynamic linear regression model to characterize the evolution of the allocation coefficient between the available cumulative net energy, which was estimated from feed intake, and cumulative weight gain during the fattening period. Longitudinal energy allocation coefficients were analysed using a two-step approach to estimate both the genetic variance of the coefficients and the genetic variance in their residual variance, which will be referred to as the log-transformed squared residual (LSR).

Results
The LSR trait, which could be interpreted as an indicator of the response of the animal to perturbations/stress, showed a low heritability (0.05 ± 0.01), a high favourable genetic correlation with average daily growth (− 0.71 ± 0.06), and unfavourable genetic correlations with feed conversion ratio (− 0.76 ± 0.06) and residual feed intake (− 0.83 ± 0.06). Segmentation of the population in four classes using estimated breeding values for LSR showed that animals with the lowest estimated breeding values were those with the worst values for phenotypic proxies of robustness, which were assessed using records routinely collected on farm.

Conclusions
Results of this study show that selection for robustness, based on estimated breeding values for environmental variance of the allocation coefficients to growth, can be considered in breeding programs for fattening pigs.