bluuebunny/crossref_metadata_2025_split huggingface dataset:
A viscoelastic–plastic constitutive model incorporating creep initiation stress for surrounding rock in deep roadways and its practical application
Authors: Kang Hui , Gong Peilin , Yi Kang , Wen Guang , Zhao Tong , Li Peng 
Published: January 2024

AbstractWith the increasing depth of engineering in rock masses, the issue of significant rheological deformation becomes notably prominent. To accurately characterize the deformation and failure behavior of the surrounding rock near the goaf in deep small coal pillars, we have developed a viscoelastic–plastic constitutive model that takes into account the initial stress associated with creep. This model builds upon an existing viscoelastic–plastic constitutive framework and is implemented numerically using C++ in the FLAC3D. The Oedometer test method is used to check the creep components and the calculated parameter (η/G) ensure convergence of numerical operations. We conducted both pre‐improvement and post‐improvement tests of the constitutive model in a simple numerical analysis of roadways. The enhanced model demonstrates improved accuracy in deviational stress calculations and proves suitable for modeling deep, soft roadways. Furthermore, we applied the improved model to simulate actual working conditions at Zhaozhuang Mine, where mining operations near the working face induce a fracture zone of approximately 3 m in the small coal pillar located at the goaf's edge. The new model closely aligns with the observed results, further validating its suitability for tunneling along the goaf. Tunneling and mining activities result in significant deformation at various locations, including the shoulder socket of the working face, the top angle of the coal pillar, and the bottom angle of the floor. The crushing zone at the working face extends up to 4 m. Rheological effects transform the triangular elastic core, from its original high‐pressure elastic state to a fracture and plastic zone in the deep coal. Stress in deep coal is transmitted along the triangular elastic core. Numerical simulation results closely match the excavation profile of the tunneling, providing valuable insights into the impact of mining activities. This study can provide reference for deformation of similar geological conditions and engineering situation.
Enhanced innate responses in microglia derived from retinoblastoma patient‐specific iPSCs
Authors: Xu Jia , Yu Si‐Jian , Sun Shuning , Li Yan‐Ping , Zhang Xiao , Jin Kangxin , Jin Zi‐Bing 
Published: January 2024

AbstractRB1 deficiency leads to retinoblastoma (Rb), the most prevalent intraocular malignancy. Tumor‐associated macrophages (TAMs) are related to local inflammation disorder, particularly by increasing cytokines and immune escape. Microglia, the unique resident macrophages for retinal homeostasis, are the most important immune cells of Rb. However, whether RB1 deficiency affects microglial function remain unknown. In this study, microglia were successfully differentiated from Rb patient‐ derived human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs), and then we investigated the function of RB1 in microglia by live imaging phagocytosis assay, immunofluorescence, RNA‐seq, qRT‐PCR, ELISA and retina organoids/microglia co‐culturing. RB1 was abundantly expressed in microglia and predominantly located in the nucleus. We then examined the phagocytosis ability and secretion function of iMGs in vitro. We found that RB1 deficiency did not affect the expression of microglia‐specific markers or the phagocytic abilities of these cells by live‐imaging. Upon LPS stimulation, RB1‐deficient microglia displayed enhanced innate immune responses, as evidenced by activated MAPK signaling pathway and elevated expression of IL‐6 and TNF‐α at both mRNA and protein levels, compared to wildtype microglia. Furthermore, retinal structure disruption was observed when retinal organoids were co‐cultured with RB1‐deficient microglia, highlighting the potential contribution of microglia to Rb development and potential therapeutic strategies for retinoblastoma.
Orofacial complications from immune checkpoint inhibitors: A retrospective analysis from two academic medical centers
Authors: Al‐Eryani Kamal , Epstein Joel B. , Monreal Anette Vistoso , Villa Alessandro 
Published: January 2024

AbstractBackgroundImmune checkpoint inhibitors (ICIs) are FDA‐approved for various cancers, yet their orofacial immune‐related adverse events (irAEs) remain poorly understood. Our two‐center retrospective study aims to better understand the prevalence and nature of these orofacial irAEs.MethodsWe retrospectively collected demographics, ICI details, and onset of orofacial irAEs in ICI‐treated patients at University of California San Francisco and City of Hope (2013–2021). Orofacial irAEs were identified by ICD‐10 codes and data categorized as dry mouth/xerostomia, oral mucosal lesions, and orofacial neuropathies. Patients with pre‐existing orofacial conditions resembling the reported irAEs were excluded.ResultsAmong 3768 ICI‐treated patients, 408 (10.8%) developed 467 orofacial irAEs: oral mucosal diseases (41.4%), dry mouth/xerostomia (41.0%), and orofacial neuropathies (17.6%). Notably, head and neck cancers had the highest incidence of orofacial irAEs.ConclusionsOrofacial irAEs are relatively common in patients receiving ICIs, necessitating careful monitoring and management of these complications during and after the treatment.
Do political connections matter for bank efficiency in times of crisis?
Authors: Abdelsalam Omneya , Mollah Sabur , Tortosa‐Ausina Emili , El‐Masry Ahmed A. 
Published: January 2024

AbstractDo political connections affect bank efficiency during crises? This study addresses this question by adopting a two‐stage approach that performs a quantile regression analysis on a unique dataset of listed banks in a region that has witnessed both financial and political crises, namely the Middle East and North Africa. Our results show that political connections are a driving force behind bank inefficiency. We find that the least efficient banks have the most significant association with political connections, thus supporting bailout theory. We also find that political connections influenced the efficiency of banks during the financial crisis, but not during the regional political crisis. Our results provide new evidence on the applicability of established political connection theories during political turmoil.
Development of pedotransfer functions for predicting saturated hydraulic conductivity in a Himalayan catchment: Sikkim, India
Authors: Deb Proloy , Das Susanta , Patle Ghanshyam T. , Elbeltagi Ahmed , Yadav Sudhir 
Published: January 2024

AbstractSaturated hydraulic conductivity (Ks) plays a vital role in irrigation and drainage system design. Generally, Ks is estimated in the laboratory; however, it is expensive and tedious, especially in the Himalayan ranges where soil sampling is challenging due to topographical constraints. Therefore, in this study, pedotransfer functions were generated using multiple linear regression (MLR) models for the predictability of Ks in a Himalayan catchment in India. Fifty soil samples were collected and divided into two groups at a 70:30 ratio. Different soil attributes derived from 70% of samples were used for MLR generation, and attributes of the remaining 30% of samples were used for model validation. Six different MLR models constituting different independent soil attributes were generated and compared statistically. The results indicate that the MLR model comprising soil texture, bulk density, particle density, soil moisture content (MC), organic carbon content and porosity results in the highest adjusted coefficient of determination (R2; 0.93 and 0.89 during model generation and validation, respectively). Additionally, it was found that the weight basis MC ranged from 14% to 29% with a median value of 24%. These results demonstrate that simple MLR models can be used as an alternative to laborious experimental setups for Ks estimation. These findings can be used as guidelines for proper irrigation planning and design in mountainous catchments.
Front Cover
Authors: Song Xianlin , Zhong Wenhua , Li Zilong , Peng Shuchong , Zhang Hongyu , Wang Guijun , Dong Jiaqing , Liu Xuan , Xu Xiaoling , Liu Qiegen 
Published: January 2024

A novel accelerated model‐based iterative reconstruction strategy for sparse‐view PAT aided by multi‐channel autoencoder priors was proposed. A multi‐channel denoising autoencoder network was designed to learn prior information, which provides constraints for model‐based iterative reconstruction. This integration accelerates the iteration process, leading to optimal reconstruction outcomes. The results show that the proposed method can achieve superior sparse‐view reconstruction with a significant acceleration of iteration. Notably, the proposed method exhibits excellent performance under extremely sparse condition.For further details please visit the article by Xianlin Song, Wenhua Zhong, Zilong Li, Shuchong Peng, Hongyu Zhang, Guijun Wang, Jiaqing Dong, Xuan Liu, Xiaoling Xu, Qiegen Liu (e202300281)image
Development of a multi‐step screening procedure for redox active molecules in organic radical polymer anodes and as redox flow anolytes
Authors: Achazi Andreas J. , Fataj Xhesilda , Rohland Philip , Hager Martin D. , Schubert Ulrich S. , Mollenhauer Doreen 
Published: January 2024

AbstractBenzo[d]‐X‐zolyl‐pyridinyl (XO, S, NH) radicals represent a promising class of redox‐active molecules for organic batteries. We present a multistep screening procedure to identify the most promising radical candidates. Experimental investigations and highly correlated wave function‐based calculations are performed to determine benchmark redox potentials. Based on these, the accuracies of different methods (semi‐empirical, density functional theory, wave function‐based), solvent models, dispersion corrections, and basis sets are evaluated. The developed screening procedure consists of three steps: First, a conformer search is performed with CREST. The molecules are selected based on the redox potentials calculated using GFN2‐xTB. Second, HOMO energies calculated with reparametrized B3LYP‐D3(BJ) and the def2‐SVP basis set are used as selection criteria. The final molecules are selected based on the redox potentials calculated from Gibbs energies using BP86‐D3(BJ)/def2‐TZVP. With this multistep screening approach, promising molecules can be suggested for synthesis, and structure–property relationships can be derived.
Optimized protocol for high‐vacuum scanning electron microscopy analysis of polyacrylamide hydrogel‐attached sperm cells in a binary system
Authors: Ebel Francisca , Ramírez‐Reveco Alfredo , Strobel Pablo , Wagenknecht Lisbeth , Rodríguez Nancy , Bosch Pablo , Rivarola Claudia 
Published: January 2024

AbstractA protocol for the analysis of a binary system comprising polyacrylamide hydrogel‐attached sperm cells using high‐vacuum scanning electron microscopy (SEM) is presented. This protocol focuses on optimizing the SEM procedure to obtain accurate and detailed imaging of the sperm cells and their interactions with the hydrogel scaffold. The methodology involves a stepwise sample preparation, including sample dehydration through a gradual exchange of ethanol/water ratios, followed by the application of a conductive metal coating. By employing this modified protocol, the traditional use of acetone dehydration, which may introduce chemical alterations to the materials, is avoided. The proposed approach enables a comprehensive evaluation of the morphology and interactions within the biological system in contact with the soft material scaffold. Furthermore, the potential application of this protocol extends to the study of other mammalian reproductive cells or cells of different origins adhered to hydrogel scaffolds.Research Highlights
Novel SEM protocol reveals precise imaging of sperm‐hydrogel attachment in a binary system, enhancing our understanding of cell‐material interactions.
By optimizing SEM procedures, the protocol achieves precise imaging of sperm‐hydrogel interactions using ethanol/water dehydration and a conductive metal coating.
This modified approach enables a thorough assessment of morphology and interactions in the binary system,extending its potential applicability to other reproductive cells on hydrogelscaffolds.
Exploring the use of mobile translation applications for culturally and linguistically diverse patients during medical imaging examinations in Australia – a systematic review
Authors: Taylor Bridget , McLean Glenda 
Published: January 2024

AbstractAustralian healthcare provides services to a vast culturally and linguistically diverse (CALD) population. Professional interpreters are the gold standard for medical interpretation during healthcare interactions with CALD patients with limited English proficiency (LEP). However, accessing interpretation services can be difficult and may not be appropriate when timely translation is needed. Mobile translation applications (MTAs) have been suggested as a way for healthcare workers (HCWs) to provide timely translation when engaging with CALD patients. This systematic review aimed to investigate the potential for MTAs to be used in Australian medical imaging (MI) departments to enhance communication and safety for CALD patients and HCWs. Enablers and limitations of MTAs were appraised for use in MI and important design considerations suggested. Results found that MTAs may enhance communication between CALD patients and MI professionals and uphold safety by more accurately performing procedure matching and healthcare assessments. MTAs also offer readily available translation during out of hours care, emergency scenarios and everyday care. However, reliability of free‐input translation and patient confidentiality were flagged as important limitations of MTAs that need to be addressed should a safe MTA be designed for MI purposes. MTAs also need to be designed with consideration for CALD patients who have low literacy levels and mental impairment. Devices should be installed close to the point of care to enable MI professionals to easily retrieve and use the MTA. MTAs used in this way can potentially improve care of CALD patients in MI when professional interpreters are absent.
Cardiac injury in hospitalized patients with severe fever and thrombocytopenia syndrome
Authors: Ding Wenqian , Gong Chen , Meng Tao , Xiang Xinjian , Hong Baoyu , Shen Shichun , Ding Shenggang 
Published: January 2024

AbstractSevere fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease with a high fatality rate. Cardiac injury in SFTS patients is a major concern. This study aimed to evaluate the prevalence of cardiac injury and its association with mortality in hospitalized patients infected with novel Bunyavirus. Cardiac injury was defined as the presence of any of the following abnormalities: (1) blood levels of cardiac biomarkers (creatine kinase‐MB, troponin‐I, B‐type natriuretic peptide or N‐terminal pro‐B‐type natriuretic peptide); (2) new abnormalities in electrocardiography. The 203 SFTS patients were included in the final analysis. The proportion of SFTS patients developing cardiac injury during hospitalization was 71.4% (145/203). Compared with the uninjured group, the cardiac injury group had the severity of cardiac injury was underscored by higher median hospital costs (31420 vs. 12911, p < 0.001), higher proportion of intensive care units admissions (13.1% vs. 3.4%, p = 0.041), and higher hospital mortality rate (33.8% vs. 6.9%, p < 0.001). Multivariable‐adjusted Cox proportional hazards regression analysis showed that cardiac injury was associated with higher mortality during hospitalization (hazards ratio, 7.349; 95% CI: 2.352–22.960). Cardiac injury is common among hospitalized SFTS patients, and it is associated with higher risk of mortality.
Transition paths for condition‐based maintenance‐driven smart services
Authors: Akkermans Henk , Basten Rob , Zhu Quan , Van Wassenhove Luk 
Published: January 2024

AbstractThis research investigates growth inhibitors for smart services driven by condition‐based maintenance (CBM). Despite the fast rise of Industry 4.0 technologies, such as smart sensoring, internet of things, and machine learning (ML), smart services have failed to keep pace. Combined, these technologies enable CBM to achieve the lean goal of high reliability and low waste for industrial equipment. Equipment located at customers throughout the world can be monitored and maintained by manufacturers and service providers, but so far industry uptake has been slow. The contributions of this study are twofold. First, it uncovers industry settings that impede the use of equipment failure data needed to train ML algorithms to predict failures and use these predictions to trigger maintenance. These empirical settings, drawn from four global machine equipment manufacturers, include either under‐ or over‐maintenance (i.e., either too much or too little periodic maintenance). Second, formal analysis of a system dynamics model based on these empirical settings reveals a sweet spot of industry settings in which such inhibitors are absent. Companies that fall outside this sweet spot need to follow specific transition paths to reach it. This research discusses these paths, from both a research and practice perspective.
Spectroscopic characterization of extra‐framework hydrated proton complexes with the extremely strong hydrogen bonds in microporous silicate minerals
Authors: Chukanov Nikita V. , Rastsvetaeva Ramiza K. , Zubkova Natalia V. , Vigasina Marina F. , Pekov Igor V. , Zolotarev Andrey A. , Mikhailova Julia A. , Aksenov Sergey M. 
Published: January 2024

AbstractMicroporous materials containing hydrated silanol groups Si–OH as well as hydrated proton complexes, H2n+1On+, including hydronium (n = 1), Zundel (n = 2), and Eigen (n = 4) cations, are of practical importance as potential ion exchangers and ion conductors. In this paper, we provide data on crystal‐chemical features, hydrogen bonding and Raman spectra of alkaline microporous titano‐, niobo‐, zircono‐, and aluminosilicate minerals belonging to the labuntsovite, lovozerite, eudialyte, and sodalite groups in which a part of sodium was substituted by hydrated proton complexes under low‐temperature hydrothermal or supergene conditions. Most minerals studied in this work do not have synthetic analogues and are considered as possible natural prototypes of microporous materials with technologically important properties. The obtained experimental data and their comparison with the results of ab initio theoretical calculations published elsewhere show that Raman spectroscopy is an effective tool for the precise identification of hydrated proton complexes with extremely strong hydrogen bonds and estimation of corresponding O···O distances in the range of 2.37–2.68 Å. The presence of hydrated proton complexes in microporous silicates is a clear and sensitive geological indicator showing that a rock underwent the low‐temperature alteration.
Sun protection knowledge, attitudes and practices: A Lebanese‐based survey
Authors: Hasbani Divina Justina , Ghaoui Nohra , Haddad Firas , Shahla William Abou , Saade Serena , Bandali Tarek , Menhem Zahraa , Saade Dana 
Published: January 2024

AbstractBackgroundDespite extensive research on sun protection, there remains a gap in certain populations like Lebanon. It is essential to assess how Lebanese adults handle sun exposure and its risks.ObjectivesTo examine the knowledge and habits of sun protection use among adults in Lebanon and explore the possible association between a history of skin cancer or photo‐related disorder and sun protection behaviours.MethodsWe conducted a single‐centre cross‐sectional study on 1001 patients presenting to the American University of Beirut Medical Center dermatology clinics from August 2020 till April 2023. Participants were between 18 and 80 years of age and recruited by convenience sampling. Those younger than 18 years old or not proficient in English or Arabic were excluded.ResultsAmong 1001 adults (mean age, 36.06 years [SD, 14.72]; 708 [71.08%] female), 512 (52.78%) use sunscreen, 449 (46.29%) do not and 9 (0.93%) do not know. Respondents with a history of a photo‐related condition (melasma, lentigos/freckles and rosacea) were significantly more likely to be sunscreen users (p < 0.001), but a history of skin cancer did not significantly increase the odds of using sunscreen (odds ratio, 1.42; 95% confidence interval, 0.79–2.56). Participants who reported obtaining their sun protection information from dermatologists and/or social media were associated with increased sunscreen use.ConclusionsThe results of this cross‐sectional survey suggest that half of the patients presenting to dermatology clinics at a tertiary care centre in Beirut tend to use sunscreen. Future investigations are needed to better understand the photoprotective awareness and practices of the Lebanese population. The lack of patients' behaviours towards skin protection should gear a nation‐wide campaign to improve these practices. Our outcomes indicate that dermatologists should be at the forefront of such campaigns tackling sun‐protective measures and skin cancer prevention, especially using social media platforms.
Arthroscopic Bankart with remplissage results in lower rates of recurrent instability with similar range of motion compared to isolated arthroscopic Bankart for anterior glenohumeral instability: A systematic review and meta‐analysis
Authors: Villarreal‐Espinosa Juan Bernardo , Kay Jeffrey , Ramappa Arun J. 
Published: January 2024

AbstractPurposeThe addition of the remplissage procedure to an arthroscopic Bankart procedure has been shown to improve clinical outcomes, yet at the expense of potentially decreasing shoulder range of motion. The purpose of this study was to assess recurrent instability, range of motion, functional outcomes and rates of return to sport outcomes in patients undergoing an isolated arthroscopic Bankart repair compared to those undergoing arthroscopic Bankart repair in addition to the remplissage procedure.MethodsAccording to the Preferred Reporting Items for Systematic Review and Meta‐Analyses (PRISMA) guidelines, a search was conducted using three databases (MEDLINE/OVID, EMBASE and PubMed). Retrieved studies were screened based on predefined inclusion and exclusion criteria for comparative studies. Data were extracted and meta‐analysis performed using a random‐effects model.ResultsA total of 16 studies (13 level III studies, 2 level II studies and 1 level I) were included with a total of 507 and 704 patients in the Bankart plus remplissage and isolated Bankart repair groups, respectively. No studies reported glenoid bone loss of >20% with the least percentage of glenoid bone loss reported among studies being <1%. There was a significantly increased rate of recurrent dislocations (odds ratio [OR] = 4.22, 95% confidence interval [CI]: 2.380–7.48, p < 0.00001) and revision procedures (OR = 3.36, 95% CI: 1.52–7.41, p = 0.003) in the isolated Bankart repair group compared to the Bankart plus remplissage group. Additionally, there were no significant differences between groups in terms of external rotation at side (n.s.), in abduction (n.s.) or at forward flexion (n.s.) at final follow‐up. Furthermore, return to preinjury level of sport favoured the Bankart plus remplissage group (OR = 0.54, 95% CI: 0.35–0.85, p = 0.007).ConclusionPatients undergoing arthroscopic Bankart plus remplissage for anterior shoulder instability have lower rates of recurrent instability, higher rates of return to sport, and no significant difference in range of motion at final follow‐up when compared to an isolated arthroscopic Bankart repair. Further large, prospective studies are needed to further determine which patients and degree of bone loss would benefit most from augmentation with the remplissage procedure.Level of EvidenceLevel III.