bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the Morphodynamic Potential of Gilort River Sections: Natura 2000 Site as Case Study
Authors: Giurea Alexandru‐Andrei , Comănescu Laura , Clius Mioara , Sterienescu Lidia 
Published: January 2025

ABSTRACTRiver dynamics involve the input of water and sediment from the watershed, shaping the interaction between flow regime, sediment transport, and channel morphology. This study aims to present a novel methodology for identifying dynamic river sectors, based on a comprehensive multicriteria analysis encompassing various natural and anthropogenic factors observed or directly measured in the field, as well as extracted from available databases. The proposed methodology relies on a spatial multicriteria analysis, a valuable method for integrating large spatial datasets and efficiently estimating the spatial distribution of dynamics at a general level. Alongside the multicriteria analysis, this study incorporates several published and validated analyzes, such as the Bank Erosion Hazard Index and Morphological Quality Index, to derive relevant indicators reflecting the current field conditions. The analysis was conducted for 14 relatively homogeneous sectors of the Gilort river, resulting in a classification of these sectors based on morphodynamic potential, ranging from very low to very high.
Monofunctional Platin‐BODIPY Bullet for Mitochondria‐Targeted Chemo‐PDT Activity
Authors: Upadhyay Aarti , Nepalia Amrita , Bera Arpan , Pal Apurba Kumar , Saini Deepak Kumar , Chakravarty Akhil R. 
Published: January 2025

AbstractMonofunctional Pt(II) complexes [Pt(GL)Cl]Cl (GL–Pt–Cl) and [Pt(RL)Cl]Cl (RL–Pt–Cl), where GL and RL are green and red‐light active PEGylated distyryl BODIPY‐terpyridine moieties, were synthesized and their photo‐ and chemotherapeutic activity studied. BODIPY‐terpyridine ligand was structurally characterized. RL–Pt–Cl showed an intense absorption peak at 658 nm (ε = 9.8 × 104 M−1 cm−1) with a shoulder at ∼624 nm and a broad emission at ∼672 nm in 10% DMSO/DPBS (Dulbecco's Phosphate Buffered Saline). It was produced 1O2 as evidenced from mechanistic studies. It displayed photocytotoxicity in red light (IC50: 0.7 µM) in MDA‐MB‐231 cells. The 2′,7′‐dichlorofluorescein diacetate assay indicated intracellular generation of reactive oxygen species. It showed chemotherapeutic activity (IC50: 13.7 µM) in A549 cells on 24 h incubation. Pt‐DNA adduct formation was proposed from the 9‐ethylguanine binding experiment. Imaging of RL‐Pt‐Cl treated A549 cancer cells displayed its mitochondrial localization. JC‐1 assay indicated loss of mitochondrial membrane potential in red light. The annexin V‐FITC/propidium iodide assay suggested cellular apoptosis.
A Self‐Amplifying Photodynamic Biomedicine for Cascade Immune Activation Against Triple‐Negative Breast Cancer
Authors: Feng Xianquan , Zhang Yan , Lin Wanjing , Li Jing , Wu Fei , Lu Qingyu , Song Hongtao , Zhang Hao , Lan Fenghua , Lu Jun 
Published: January 2025

AbstractThe efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is significantly hindered by its low immunogenicity and immunosuppressive tumor microenvironment. Non‐invasive photodynamic therapy (PDT) is increasingly recognized as a potential immunotherapeutic stimulant in the treatment of TNBC. However, photodynamic immunotherapy is constrained by tumor hypoxia and excessive inflammation suppression during the course of treatment. Herein, a simple and efficacious biomedicine is formulated to overcome adverse influences by amplifying photodynamic immunotherapy, thereby stimulating the systemic immune response. Specifically, the approach targeted tumor delivery by employing specific agents such as the photosensitizer (verteporfin), the hypoxic ameliorator (atovaquone), and the cyclooxygenase‐2/prostaglandin E2 (COX‐2/PGE2) signaling blocker (celecoxib). More importantly, the biomedicine effectively ameliorated hypoxia and inhibited COX‐2/PGE2 signaling, thereby amplifying PDT‐induced immunogenic cell death. This, in turn, enhanced the efficacy of photodynamic immunotherapy and triggered a robust immune response cascade. Notably, the self‐amplifying photodynamic biomedicine significantly inhibited primary tumors, distal tumors, lung metastases, and post‐operative recurrence while maintaining high biocompatibility. To sum up, the work provides a viable cascade stimulation approach and an efficient biomedical nanoplatform, offering a novel strategy for photodynamic immunotherapy of TNBC in the clinic.
DNA Origami Framework‐Based Spatial Nanochip for Circular ssDNA Assembly and Data Storage
Authors: Wang Shengwen , Yang Donglei , Li Jiankai , Bao Hongliang , Pan Shufan , Huang Kui , Shao Jialin , Yang Qiulan , Chen Xiao , Jiang Xingyu , Wang Pengfei , Yang Yang 
Published: January 2025

AbstractA 3D DNA spatial chip (DSC) based on an icosahedral DNA origami framework is introduced to construct customized circular single‐stranded DNA (c‐ssDNA) for data storage. Within the confined space of the DSC, thirty addressable location sequences extending from the framework edges are available for designing circular paths and directing the assembly of a series of information oligonucleotides for efficient ligation. This strategy is verified by constructing c‐ssDNAs from up to 15 fragments to encode two poems (800 and 860 nucleotides). Using orthogonal location sites, both poems are simultaneously assembled within a single DSC and read out together. Rolling circle amplification (RCA) and nanopore sequencing enable complete retrieval of all the above data files. The DSCs with distinct fluorescent labels and capture sequences are further functionalized on their outer surfaces, allowing magnetic bead‐based retrieval and rapid identification of specific datasets from a mixture. Moreover, the DSCs maintain data integrity after storage under various conditions. These findings demonstrate that the 3D DNA spatial chip provides an efficient approach for assembling long c‐ssDNA for data storage, addressing limitations by reducing redundancy, enhancing stability, and enabling multiplexed storage and retrieval.
Conductive Textile Embedded with Bioinspired Wettability for Prolonged and Energy Efficient Thermal Management
Authors: Sarkar Debasmita , Ali Haydar , Singh Rajan , Phukan Anirban , Mishra Chittaranjan , Paily Roy P. , Manna Uttam 
Published: January 2025

AbstractThe design of electrically conductive textiles appears to be a promising approach to combat the existing challenge of deaths caused by severe cold climates around the globe. However, reports on the scalable fabrication of tolerant conductive textiles maintaining a low electrical resistance with an ability for unperturbed and prolonged performance are scarce. Here, a breathable and wrappable water‐repellent conductive textile (water‐repellent CT) with electrothermal and photothermal conversion abilities at low external voltage and in weak solar light is introduced, respectively. In the current approach, less carbon‐containing silver nanowires (AgNWs) are selected to spray deposit on a commercially available woven textile to attend a uniform and highly conductive network over a large dimension. The subsequent spray deposition of a reaction mixture of selected small molecules prevents aerial oxidation of deposited AgNWs even at elevated temperatures and provides bioinspired extreme water‐repellence. Thus, it maintains an unperturbed performance even when exposed to different aqueous environment. Using the scalability of current approach and durability of prepared water‐repellent CT, relevant wearable devices are derived to demonstrate personal heat management ability with rechargeable and portable battery for prolonged duration in severely cold conditions. Thus, the prepared water‐repellent CT enabled an energy‐efficient and “wrappable” heating, providing a basis for various potential applications.
Hybrid Transactional/Analytical Graph Processing in Modern Memory Hierarchies
Authors: Baumstark Alexander , Jibril Muhammad Attahir , Sattler Kai-Uwe 
Published: January 2025

Abstract
Today’s enterprise computing architectures are characterized by a complex memory hierarchy: different application requirements in terms of latency, bandwidth, persistence, and access pattern, as well as characteristics of available memory and storage technology require combining different technologies. Building highly efficient data management and analytics solutions that meet the challenges of modern applications requires to utilize this memory hierarchy, i.e., taking the specific characteristics of a given technology into account and keeping data objects in the optimal level. In this paper, we present results of our project on exploiting modern memory hierarchies in support of hybrid transactional/analytical processing (HTAP) on graph data. First, we discuss the design and evaluation of data structures and query operations for graph data in persistent memory. Second, we present an approach to support the analysis of graph data on GPU-based accelerators with dedicated memory by efficient data transfer and consistency mechanisms. Finally, we propose a storage and processing strategy for (bi-)temporal graphs using temporal materialized views while exploiting the memory hierarchy.
Self-Contact Preventing Energy for Tubular Rods
Authors: Lonati Chiara , Marzocchi Alfredo 
Published: January 2025

Abstract
We introduce a generalization of Möbius energy for knots to an energy functional for tubular neighbourhoods of closed inextensible curves. We prove the continuity of the energy and its boundedness for physically admissible tubes without self-contact and in particular for the torus. The functional allows to distinguish isotopy classes of the centreline through its physical resemblance to a self-repulsive electrostatic energy. If the tube has zero thickness, O’Hara’s functional is recovered. Finally, a discussion on the possible exponents in the functional is carried out and numerical examples are studied to highlight some advantages of our new definition.
Effect of antiplatelet and anticoagulant medications on implant survival: a long-term retrospective cohort study
Authors: Chatzopoulos Georgios S. , Wolff Larry F. 
Published: January 2025

Abstract

Purpose
This large-scale retrospective study aimed to examine the long-term effect of antiplatelet and anticoagulant medications intake on dental implant treatment outcome.

Materials and methods
This study retrospectively examined data from patients who underwent dental implant procedures at several university dental clinics within the BigMouth network between 2011 and 2022. Patients’ characteristics including age, gender, ethnicity, race, tobacco use, systemic medical conditions and intake of antiplatelets and anticoagulants were analyzed. Implant treatment outcome was the main outcome variable. Implant failure was defined as the removal of a dental implant for any reason. Time to failure (date of procedure to date of visit with failure) was recorded, while sites without a failure were censored at the last follow-up visit.

Results
A total of 50,333 dental implants in 20,842 patients over 12 years were analyzed and an implant failure rate of 1.4% at the implant level and 2.7% at the patient level were found. Asians, African-Americans, American Indians or Alaskan Natives, and White individuals were significantly more likely to receive antiplatelet medications than Hispanics or Latinos. Males and smokers exhibited significantly higher odds of being antiplatelet and anticoagulant users compared to females and non-smokers, respectively. When the implant survival rates between antiplatelet and anticoagulant users were compared to non-users, no significant differences were observed.

Conclusion
Within the limitations of this study, it appears that the use of anticoagulant and antiplatelet medications does not affect the risk of implant failure. Both anticoagulant and antiplatelet users and non-users exhibit similar high implant survival rates.
Management and outcome of mesh infection after abdominal wall reconstruction in a tertiary care center
Authors: Franchi Victor , Triffault-Fillit Claire , Jarraud Sophie , Mabrut Jean-Yves , Javaux Clément , Monneuse Olivier , Conrad Anne , Ferry Tristan , Robert Maud , Ader Florence , Passot Guillaume , Valour Florent 
Published: January 2025

Abstract

Purpose
Abdominal wall reconstruction is a common surgical procedure, with a post-operative risk of mesh-associated infection of which management is poorly known. This study aims to comprehensively analyze clinical and microbiological aspects of mesh infection, treatment modalities, and associated outcomes.

Methods
Patients with abdominal mesh infection were included in a retrospective observational cohort (2010-2023). Patients characteristics and management were described, and determinants for failure were assessed by logistic regression and treatment failure-free survival curve analysis (Kaplan-Meier).

Results
Two hundred and nine patients (median age, 62 [IQR, 55-71] years) presented a mesh infection occurring within 15 (IQR, 7-31) days after surgery, mainly as an abdominal wall or deep abscess (n=189, 90.4%). Infection was polymicrobial in 89/166 (79.4%) cases, S. aureus (n=60, 36.1%), Enterobacteriaceae (n=60, 36.1%) and anaerobes (n=40, 24.1%) being the most prevalent pathogens. Surgery was performed in 130 (62.2%) patients, associated with a 13.5 (IQR, 8-21) day course of antimicrobial therapy in 172/207 (83.1%) cases. Sixty-three (30.1%) treatment failures occurred, associated with previous multiple abdominal surgeries (OR, 3.305; 95%CI, 1.297-8.425), complete mesh removal (OR, 0.145; 95%CI, 0.063-0.335) and antimicrobial therapy (OR, 0.328; 95%CI, 0.136-0.787). The higher failure rate of conservative strategies was associated with symptom duration >1 month (OR, 3.378; 95%CI, 1.089-4.005) and retromuscular mesh position (OR, 0.444; 95%CI, 0.199-0.992).

Conclusion
Mesh infection is associated with high treatment failure rates. Complete mesh removal coupled with targeted antibiotic therapy is associated with better outcomes. Conservative treatment strategies must rely on careful patient selection based on symptom duration and mesh placement.
Factors influencing success of virtual reality in Tunisia’s cultural heritage tourism sites: a UTAUT2 approach extension
Authors: Mosbeh Rim 
Published: January 2025

Abstract
The tourism industry is evolving rapidly with the emergence of virtual reality (VR), seen as a viable alternative to traditional travel. Our primary aim is to identify the factors influencing the success of VR and provide recommendations for resources, methods, and technology. Our study presents a multi-dimensional conceptual model for the pre-implementation success of VR in the tourism sector. We applied the UTAUT2 model with an additional contextual concept. Data from 352 participants support our model for assessing perceived VR success in Tunisian tourism. The study confirms the significant positive impact of performance expectancy, hedonic motivation, and facilitating conditions on behavioral intention. Personal innovativeness and trust expectancy positively influence performance expectancy. Conversely, effort expectancy negatively affects hedonic motivation. In summary, our research validates the model's suitability for assessing the intention to use VR in tourism activities. This framework is crucial as VR continues to revolutionize the tourism industry.
Lateral pelvic lymph node dissection (LPLND) in the treatment of rectal cancer: current practice and evolving approaches in India
Authors: Sharma Ankit , Manohkaran Subhathira , Saklani Avanish 
Published: January 2025

Abstract

Background
The introduction of total mesorectal excision improved locoregional control for rectal adenocarcinoma significantly. Standardisation of the technique of LPLND is lacking in literature.

Methods
We describe the current practices of case selection and technical details of lateral lymph node dissection in rectal cancer. We also describe the approach when post neo-adjuvant fibrosis renders standard resection unsafe.

Results
Careful case selection and standardisation of the lateral lymph node dissection technique is important to ensure an oncologically sound and surgically procedure . Step-by-step procedures of LPLND are described in this article, and a video is demonstrated.

Conclusions
Standardisation of the techniques of lateral lymph node dissection is essential. The procedure has a definite learning curve, requiring considerable expertise to avoid complications and achieve optimal outcomes.
Exploring novel immunotherapy in advanced esophageal squamous cell carcinoma: Is targeting TIGIT an answer?
Authors: Chuang Chien-Huai , Guo Jhe-Cyuan , Kato Ken , Hsu Chih-Hung 
Published: January 2025

Abstract
Esophageal squamous cell carcinoma (ESCC) is a prevalent and highly lethal malignancy in Asia. Recent advancements in immune checkpoint inhibitors (ICIs) have markedly transformed the systemic therapy landscape for ESCC. Anti-PD-1-based combination with chemotherapy or with ipilimumab, an anti-CTLA-4 antibody, have been established as the new standard first-line treatments for patients with advanced ESCC. Moreover, anti-PD-1 monotherapy has demonstrated improved efficacy and survival compared with second-line chemotherapy in previously treated patients with ESCC. Novel ICIs targeting other immune checkpoints also show potential for enhancing anticancer therapy in advanced ESCC.The TIGIT/PVR pathway represents a new immune checkpoint. Preclinical studies have indicated that the dual blockade of TIGIT and PD-1 can enhance antitumor immune responses. Clinical trials have reported that combining anti-TIGIT with anti-PD-1/PD-L1 antibodies elicited clinical responses in patients with advanced ESCC. In the first-line systemic therapy setting, combinations of dual ICIs targeting TIGIT and PD-1/PD-L1 plus platinum-based chemotherapy have demonstrated acceptable toxicity profiles and promising antitumor activity in several phase II trials and one phase III study. However, the role of adding an anti-TIGIT antibody to the current standard of anti-PD-1/PD-L1 plus platinum-based chemotherapy in first-line therapy for advanced ESCC remains to be fully determined, necessitating further clinical trials. Ongoing studies are also investigating the role of anti-TIGIT, with or without anti-PD-1/PD-L1, in locoregional ESCC. Additional research is essential to optimize the potential of anti-TIGIT therapy in ESCC and other malignancies by identifying predictive biomarkers, determining optimal antibody types, and gaining key mechanistic insights.
Charity Principles in Philosophical Argumentation
Authors: Shields R. A. J. 
Published: January 2025

Abstract
This essay explores what it is to be a principle of charity in philosophical argumentation. In it, I explore some principles of charity found in classic and contemporary literature and textbooks on logic and philosophy. I distinguish between what I will maximal and sub-maximal principles of charity. With this distinction, I taxonomize current principles of charity on offer according to their dialectical function as rules for argument interpretation and reconstruction in philosophical argumentation. Principles of charity, I argue, are best construed as pragmatic rules for argument interpretation in philosophical argumentation, not merely moral or ratio-epistemic rules. I defend this claim against some objections.
A second-order sequential optimality condition for nonlinear second-order cone programming problems
Authors: Fukuda Ellen H. , Okabe Kosuke 
Published: January 2025

Abstract
In the last two decades, the sequential optimality conditions, which do not require constraint qualifications and allow improvement on the convergence assumptions of algorithms, had been considered in the literature. It includes the work by Andreani et al. (IMA J Numer Anal 37:1902–1929, 2017), with a sequential optimality condition for nonlinear programming, that uses the second-order information of the problem. More recently, Fukuda et al. (Set-Valued Var Anal 31:15, 2023) analyzed the conditions that use second-order information, in particular for nonlinear second-order cone programming problems (SOCP). However, such optimality conditions were not defined explicitly. In this paper, we propose an explicit definition of approximate-Karush-Kuhn-Tucker 2 (AKKT2) and complementary-AKKT2 (CAKKT2) conditions for SOCPs. We prove that the proposed AKKT2/CAKKT2 conditions are satisfied at local optimal points of the SOCP without any constraint qualification. We also present two algorithms that are based on augmented Lagrangian and sequential quadratic programming methods and show their global convergence to points satisfying the proposed conditions.
Trust as a weapon of war: fighting corruption and corporate crime in Ukraine
Authors: Markovska Anna , Serdiuk Oleksii , Soldatenko Iryna 
Published: January 2025

Abstract
We explore the ways in which elite crimes impact the development of society, and specifically address the harmful impact of such activities on social trust. We single out the issue of corruption in Ukraine during the Russian war to analyse the ways in which political elites exploit social trust in emergency situations. Employing a critical criminological approach to crime and justice, we analyse the effect of anti-corruption reforms in Ukraine, paying particular attention to the issue of trust to consider how and why trust has been “weaponized” by war. The war has changed Ukrainian attitudes towards state authorities and engendered in them a remarkably high degree of trust. We hypothesise that this change is based more on emotion than on rationality. The understanding of how and why the political elite might use this trust in the future is important for the development of anti-corruption policy both in Ukraine and generally in Europe. We conclude that the weaponization of trust poses a number of risks to advancing anti-corruption efforts in Ukraine. Sustaining progress in this area, therefore, will require a careful navigation of competing wartime priorities.
“Respect and Suspect” – Perceptions and Experiences of Women in Recovery from a Substance Use Disorder of their Relationships with Men
Authors: Kelner Jenia , Kaufman Romi Gemer , Gavriel-Fried Belle 
Published: January 2025

Abstract
Women in recovery from substance use disorder (SUD) face multiple, specific challenges. Establishing healthy and close relationships can contribute to women’s mental health and enhance their recovery. Unhealthy relationships with men are a key factor in women’s onset of drug use, relapse, and attempts to recover from a SUD. Given their frequent personal history of sexual trauma, violence, and abuse caused by men, women recovering from SUD need to cope with multiple relational issues. This study explored the perceptions and experiences of women in recovery from SUD as regards their relationships with men. Fourteen women treated in women-only residential programs for SUD were interviewed using a qualitative-naturalistic approach. Inductive content analysis identified four categories: (1) From disgust and mistrust to attraction to boys and men in the context of abuse, (2) Exploitative relationships: use and be used, (3) The absent predator: justifications for the absence of men in women-only residential treatment program, and (4) Old patterns alongside new insights into recovery. These categories were contextualized conceptually in terms of the dialectic between “Respect and Suspect”. The findings, as interpreted through the lens of Relational Agency theory, highlight changes in power dynamics within relationships over the course of recovery. Clinical social workers should be aware of the multifaceted nature of attitudes towards relationships with men in women with SUD, to better help these women establish healthier, more secure relationships as a part of their recovery.