bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of Catheter Treatment of Non-Isthmus-Dependent Atrial Flutter
Authors: Almiz Pavlo O. , Kravchuk Borys B. , Maliarchuk Rostyslav H. , Perepeka Eugene O. , Tymoshenko Dmytro A. , Pokanevich Alona V. 
Published: September 2023

Atrial flutter (AF) is caused by the re-circulation of the wave of electrical excitation of the myocardium (reentry) around the anatomical substrate which circulates within the atrial tissues. This is always a macro re-entry. Such an anatomical barrier, around which circulation can occur, can be the superior or inferior vena cava, rings of the tricuspid or mitral valves, the mouth of the coronary sinus, pulmonary veins, postoperative scar.
The aim. To determine the specifics of elimination, success rate, and long-term outcome with various preablation and postablation diagnostic techniques for non-isthmus-dependent atrial flutter (NIDAFL).
Materials and methods. The study included 26 patients who underwent radiofrequency ablation of atypical NIDAFL.
Results. As a result of radiofrequency ablation, a sinus rhythm was restored in 17 patients during the procedure. In 7 cases, when the typical, isthmus-dependent AF was removed, the tachycardia cycle and the morphology of the R wave changed. Mapping showed that in 7 cases the direction of the re-entry front changed, and instead of the circulation of excitation through the cavatricuspid isthmus, it then passed around the atriotomy scar. In 2 cases, a change in the cardiac cycle was observed after radiofrequency ablation, but the excitation circulation was the same around the atriotomy scar, only the tachycardia cycle increased. As a result of the use of our techniques, arrhythmia was eliminated in all 21 patients with an atriotomy AF during one procedure. Five patients with AF of a different localization of the re-entry circuit also had their arrhythmia eliminated, although 8 procedures (for five patients) were performed (on average 1.6). There were no complications. During the follow-up period of 1.8±0.7 years, 2 patients had a recurrence of arrhythmia, and they underwent a repeat procedure to eliminate the arrhythmia. One patient developed typical AF that had not been observed before, which was successfully eliminated.
Conclusion. Catheter treatment of atypical NIDAFL is quite a non-trivial task, because, as our experience shows, several types of tachycardia occur in a significant number of patients. In cases of restoration of sinus rhythm as a result of the application, it is necessary to check the inducibility of another arrhythmia. But despite everything, catheter removal of NIDAFL is quite effective, especially for atriotomy AF, although it requires more X-ray exposure and a relatively large number of applications. The use of navigation systems has helped to improve the results of such interventions in more complex cases.
Immunological Reactivity and Intensity of Oxidative Stress in Stable Coronary Artery Disease
Authors: Gavrilenko Tetiana І. , Lomakovskyi Oleksandr M. , Pidgaina Olena A. , Rasputniak Olga V. , Ryzhkova Nataliia O. , Grechkovskaya Natalia V. 
Published: September 2023

The aim. To analyze the relationship between immune response factors and the intensity of oxidation of lipoproteins and proteins in patients with stable coronary artery disease (CAD) to clarify the pathogenesis of coronary atherosclerosis.
Materials and methods. A total of 179 patients with stable CAD of II-IV functional class, mean age 56 (49-62) years (main group) and 30 healthy individuals, mean age 49 (45-53) years (control group) were examined. The material for immunological research was peripheral venous blood. To determine the indicators of immunity, flow laser cytometry and enzyme-linked immunosorbent assay were used. Spectrophotometric and fluorometric methods were used to determine the levels of intermediate and final oxidation products of lipids and proteins, as well as antioxidant protection enzymes in the blood serum and in atherogenic lipoproteins.
Results. A direct relationship between the activity of lipoprotein peroxidation and protein oxidation with a cell-type immune response and immune inflammation was revealed.
Conclusions. The high intensity of lipid peroxidation and protein oxidation in patients with stable CAD (stable angina pectoris) is combined with significant activation of the T-cell component of the immune response (in terms of the ratio of helper and cytotoxic subpopulations of T-lymphocytes, high concentrations of pro-inflammatory cytokines, the state of the CD40/CD40L system, the level of expression of the CD95 apoptosis marker on cells), which indicates interdependence of T-cell immunity and oxidative stress in the pathogenesis of atherosclerosis. The dependence of the hyperproduction of pro-inflammatory cytokines by mononuclear blood cells on free radical oxidation of proteins, peroxidation of apoB proteins and the intensity of antiperoxide protection (catalase and superoxide dismutase enzymes) in patients with stable CAD indicates a contribution to the presence of oxidative stress and the development of immune inflammation. A comprehensive study of the factors of immunological reactivity, the violation of which can lead to the development of immunopathological reactions, and the intensity of oxidation of lipoproteins and proteins in patients with stable CAD helps to clarify the pathogenetic relationship between chronic immune inflammation, endothelial dysfunction and oxidative stress, and also substantiates the expediency of general therapeutic approaches to the treatment of CAD.
Non-Vitamin K Antagonist Oral Anticoagulants in Differentiated Approach to the Use in Cardiological Practice: Literature Review
Authors: Vozniuk Larysa A. , Dzekan Olga V. , Siromakha Sergii O. 
Published: September 2023

Non-vitamin K antagonist oral anticoagulants (novel oral anticoagulants, NOACs) are important pharmaceuticals for prevention of stroke and systemic embolism in non-valvular atrial fibrillation patients. Vitamin K antagonist warfarin usage is limited due to its pharmacokinetic and pharmacodynamic parameters. In modern conditions, NOACs are widely used. This literature review includes the most interesting clinical studies where anticoagulants were used. Main pharmacological properties of non-vitamin K antagonist oral anticoagulants have been investigated in these clinical studies.
The aim. To answer the question about which anticoagulant is preferable for use in particular clinical situation.
Results. In order to prevent venous thrombosis, conservative and surgical treatment is used. It is the use of anticoagulants during conservative therapy that allows to extend the life expectancy of patients at high risk of thrombosis. Unlike warfarin, the use of NOACs helps to avoid high risk of bleeding. Drugs of this group have short half-life, standard dosage, and predicted pharmacological effect.
Conclusions. New data about comparative efficacy and safety of treatment with NOACs (dabigatran, rivaroxaban, edoxaban, apixaban) in order to prevent thromboembolism in patients with atrial fibrillation are presented. The peculiarities of anticoagulant therapy in elderly patients, patients with coronary artery disease, atrial fibrillation, chronic kidney disease, patients in pre- and postoperative periods are discussed. Prolonged study of drugs of this group will enable doctors to use them without endangering the patients’ lives. NOACs, despite obtained data about their effectiveness and safety, in our opinion, deserve attention and require further study.
Surgical Correction of Dissecting Aortic Aneurysms Combined with Coronary Bypass Surgery in Marfan Syndrome
Authors: Zhekov Ihor I. , Kravchenko Vitalii I. , Sarhosh Oleh I. , Osadovska Iryna A. , Rudenko Anatoliy V. 
Published: September 2023

Introduction. The cohort of patients with aortic dissection and coronary heart disease is very complex, and their surgical treatment remains a relevant and debatable topic to this day. The presence of Marfan syndrome (MS) makes this difficult group of patients even more challenging. In this work, we present our own seven-year experience with the analysis of the impact of MS on the results of surgical treatment of patients with dissecting aortic aneurysm and coronary heart disease.
Materials and methods. Nineteen consecutive cases of dissection of the aorta combined with lesions of the coronary arteries were analyzed. All the patients were operated at the premises of the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine from 2013 to 2022. Among them, 15 operations (78.9%) were performed for type A acute dissection of the aorta, 4 (21.1%) for type A chronic dissection of the aorta. Of the 19 operated patients, 5 (26.3%) had a diagnosed MS, 14 (73.7%) were the control group of patients with aortic dissection correction and aortocoronary bypass without MS.
Results. A comparative analysis of two groups of patients showed more profound structural changes of the aortic wall especially with MS, which may affect the technical features of surgical intervention in this cohort of patients. Analysis of the mean time of perfusion, aortic clamping and intraoperative blood loss showed that the above indicators were not significantly different in both groups (p > 0.05). Indicators such as length of stay in the intensive care unit, length of stay on a ventilator, and the postoperative level of creatine phosphokinase-MB also were not significantly different in the observed groups.
Discussion. In our study, we evaluated the effect of the presence of MS on the results of surgical correction of aortic dissection and coronary artery bypass grafting. According to the results of our study, it can be stated that MS does not significantly affect the results of surgical treatment, provided that careful approach to planning the operation is employed, and all available intraoperative methods that reduce the risk of postoperative complications are used.
Conclusions. MS significantly accelerates the formation of aortic aneurysm, and also makes it more dangerous in the occurrence of acute dissection. In the group of patients with MS, damage to coronary arteries in most cases was associated with their involvement in the process of dissection, and only in some cases with atherosclerotic lesions. The use of all methods of bleeding prevention, as well as myocardial protection, allows to perform surgery in patients with MS with minimal risk.
IMPLEMENTASI KEBIJAKAN PELAYANAN KESEHATAN BAGI PENGGUNA BPJS DI PUSKESMAS MASALEMBU KABUPATEN SUMENEP
Authors: Zamzami Kudwah , Hayat Hayat 
Published: September 2023

Badan pelaksana Jaminan Sosial adalah sebuah badan hukum untuk melaksanakan program jaminan sosial. Namun demikian, pada aspek program BPJS khususnya di kepulauan masalembu masih membutuhkan perhatian khusus. penelitian ini bertujuan untuk mendeskripsikan implementasi kebijakan pelayanan bagi pengguna badan penyelenggara jaminan sosial di kantor puskesmas masalembu kabupaten sumenep. Penelitian ini menggunakan model implementasi menurut Reny Nugraheni guna mendeskripsikan tentang implementasi program BPJS. Metode penelitian dalam penelitian ini yaitu menggunakan deskriptif kualitatif. Hasil dari penelitian ini menunjukkan bahwa implementasi kebijakan dapat di tinjau dari lima faktor. Diantaranya; (1).Tersedia; pelayanan, tempat UGD, USG, Serta lab sudah tersedia. (2). Dapat diterima; program BPJS sepenuhnya dapat di terima oleh masyarakat masalembu. (3). Mudah dicapai; lokasi yang tersedia sepenuhnya dapat ter akses oleh masyarakat sehingga pengaturan distribusi sarana kesehatan menajadi hal yang pokok. (4). Dapat dijangkau; adanya program BPJS tentunya dapat menjakau dan membantu finansial masyarakat. (5). Bermutu; bahwa kebermutuan program BPJS sudah maksimal dan sesuai dengan standar yang telah di tetapkan. Kemudian dari segi hambatan, Sedikitnya ada tiga : pertama, dari segi sumber daya manusia. Kedua, internet dan infrastruktur. Ketiga, birokrasi. dan terakhir tentang kurang meratanya informasi tentang adanya program BPJS.
Effect of Spirulina Platensis on Liver Malondialdehyde Levels of Male White Rat Induced by High Dose Paracetamol
Authors: Vanny Anggilia , E. J. Tehupuring Sihning , Ngesti Rahayu Indri , Indrawati Roostantia 
Published: September 2023

Paracetamol is widely used in therapy, yet it becomes hepatotoxic agent in a high dose using. The CYP450 enzyme metabolizes a small portion of paracetamol to a reactive substance, NAPQI. High dose of paracetamol causes an extensive increase in NAPQI levels. NAPQI then binds to hepatocytes conditions of oxidative stress. Spirulina platensis contains C-phycocyanin, flavonoids, and phenolics that inhibit lipid peroxidation and reduce oxidative stress. This study aims to determine the effect of Spirulina platensis on MDA levels in the liver tissue of male Wistar rats induced by high dose of paracetamol. This research was experimental with a Randomized Post-test Only Control Group design using 24 white male rats divided into three groups; negative control group (G-), positive control group (G+) was given paracetamol at a dose of 1,250 mg/kg on the 8th day, and treatment group (Gt) was given an amount of Spirulina platensis extract 360 mg/kg BW/day for ten days from 1st until 10th day and paracetamol at a single dose of 1,250 mg/kg BW on the 8th. At the 10th day of the treatment, all groups were terminated for liver tissue collection. TBA test was used to calculate MDA levels. Statistical tests analyzed the results of the data. This statistical tests by SPSS software: MDA levels in the treatment group did not significantly differ (p = 0.144) compared to the negative control group. There was a significant difference of liver tissue MDA levels in the treatment group (p = 0.016) compared to the positive control group. This study concludes that administering Spirulina platensis at a dose of 360 mg/kg/day for ten days can help prevent on increase in tissue MDA levels and maintain liver conditions close to their original state.
DOĞAL MİRASIN KÜLTÜREL MİRAS İLE BULUŞMASI: VOLKANİZMA VE TARİHÖNCESİ YERLEŞİM STRATEJİLERİ İLİŞKİSİ AÇISINDAN VOLKANİK KAPADOKYA
Authors: GÜNGÖRDÜ Fevzi Volkan 
Published: September 2023

ÖZET
Orta Anadolu Bölgesi’nin güneydoğu bölümünü oluşturan Volkanik Kapadokya Bölgesi volkanizma temelli yeryüzü şekillerinin çeşitliliği açısından Anadolu’nun unik bölgeleri arasında gösterilebilir. Volkanizmanın bir sonucu olarak ortaya çıkan lav akıntılarının, buzul çağlarının düşük sıcaklık değerlerinin bir sonucu olarak ani donmaları sonucunda oluşan obsidiyenin Yakındoğu’da ki sınırlı kaynakları arasında gösterilen Volkanik Kapadokya bölgesi bu ayırıcı niteliği sebebiyle hem birçok tarihöncesi yerleşim yerine ev sahipliği yapmış hem de Yakındoğu’nun diğer bölgeleri ile tarihöncesi dönemlerde yoğun ilişkiler kurmuştur. Dolayısıyla Volkanik Kapadokya Bölgesi’nin doğal mirasının temelini oluşturan volkanizmanın bir sonucu olan obsidiyen bölgenin kültürel mirasının başlangıcı olarak kabul edebileceğimiz tarihöncesi yerleşim yerlerinin kurulması ve komşu bölgelerdeki tarihöncesi yerleşimler ile kurulan ilişkilerin ana konusunu oluşturmaktadır. Bu bağlamda Volkanik Kapadokya Bölgesi doğal miras ve kültürel mirasın buluştuğu ünik bir bölge olarak tanımlanabilir. Bu makale doğal miras kültürel miras ilişkisini volkanizma ve tarihöncesi yerleşimler üzerinden değerlendirmektedir.
DİJİTAL SÜREÇLERİN DOĞAL VE KÜLTÜREL MİRAS TURİZMİNİN GELİŞİMİNE ETKİSİ
Authors: YARALI Cihan , ÖZÇELİK BALOĞLU Özge 
Published: September 2023

Turizm, dünya çapında doğal ve kültürel mirasın tanıtılması ve korunmasında önemli bir rol oynamaktadır. Dijitalleşmenin gelişiyle birlikte turizm endüstrisi üzerinde dönüştürücü bir etki olmuştur. Bu makalede, doğal ve kültürel miras turizmi ile dijitalleşme arasındaki ilişkiyi araştırılmış ve beraberinde getirdiği fırsatları ve zorlukları vurgulanmıştır. Dijital teknolojilerin turizm deneyiminde nasıl devrim yarattığını, erişilebilirliği nasıl artırdığını ve koruma çabalarını nasıl kolaylaştırdığı incelenmiştir. Ayrıca, miras turizminin dijitalleştirilmesiyle ilgili potansiyel riskler ve etik hususlar araştırılmıştır. Bu makale, doğal ve kültürel miras turizmi ile dijitalleşme arasındaki kesişime kapsamlı bir genel bakış sunmayı amaçlamaktadır. Doğal ve kültürel miras alanları, farklı bölgelerin eşsiz manzaralarını, tarihi eserlerini ve geleneklerini keşfetmek ve deneyimlemek isteyen turistleri uzun süredir cezbetmektedir. Teknolojideki gelişmelerin yönlendirdiği dijitalleşmenin ortaya çıkışı, turizm de dâhil olmak üzere çeşitli sektörlerde devrim yaratmıştır. Dijitalleşme ile doğal ve kültürel miras turizmi üzerindeki etkisi incelenmiş, potansiyel faydaları, zorlukları ve sonuçları keşfedilmeye çalışılmıştır.

ABSTRACT
Tourism plays an important role in the promotion and protection of natural and cultural heritage worldwide. With digitalization, on the tourism industry; It has had a transformative effect in terms of visitor satisfaction, informed circulation, efficiency and process facilitation. Natural and cultural heritage sites have long attracted tourists who want to explore and experience the unique landscapes, historical monuments and traditions of different regions. The emergence of digitalization driven by developments in technology has revolutionized various industries, including tourism. In this article, the relationship between natural and cultural heritage tourism and digitalization has been explored and the opportunities and challenges it brings are highlighted. Successful practices are exemplified by examining how digital technologies revolutionize the tourism experience, increase accessibility, and facilitate conservation efforts. Different perspectives have been tried to be put forward, especially on issues such as sustainability, education, visitor experience, and local economy. In addition, the potential risks and ethical considerations associated with digitizing heritage tourism are explored. This article aims to provide a comprehensive overview of the intersection between natural and cultural heritage tourism and digitalization and is expected to shed light on specific future studies.
The Sum Two of Hermitian Operators Ai=Ti+Mi for Solving the Equations{Ai X=Ui },i=1,2
Authors: Sadiq Eman 
Published: September 2023

In this work we study a new class of equations (Ti+Mi)X=Ui, i=1,2 including the sum two of Hermitian operatorsTi and Mi , i=1,2, concerning the kind of spaces are Hilbert. The existence of joint Hermitian solutions to summing two equations of operators has been found under both necessary and sufficient conditions. The n*1 block's Moore-Penrose inverse of summing two matrix of operators has been studied. Therefore, we present Hermitian solutions of the two equations of operators (Ti+Mi)X(Qi+mi)=Ui, i=1,2 with finding of it’s the necessary and sufficient conditions.
Evaluating the toxic efficacy of some bio-insecticides against mature stages of whitefly insect (Bemisia tabaci).
Authors: Hanash Alyaa abdul-ridha 
Published: September 2023

This work was conducted to assess the effectiveness of three bio- insecticides (Spinosad, Abamectin and Thiomethoxam) against the mature stages of the whitefly (Bemisa tabaci): Aleyrodidera. HomoPtera . The results showed all pesticides it was active in decreasing the population density of adults in first day after spraying, after which its effectiveness it started to decrease after the 3rd and 7th day of spraying, on the other hand, the lowest population density of nymphs was recorded from day 7 onwards after 2nd spray with pesticides. 17.42 adults/10 leaves and 9.82 nymphs/16 cm2 was the lowest population density after 2nd spray of pesticides comparison with the durations before spraying and the 1st spray, which reached rate of population density (55.14 and 25.37) adults 10/leaf and (47.93 and 21.8) nymphs 16/cm2 respectively, Spinosad pesticides were characterized reduced the population density of adult after (1 and 3) days for each of the 1st spray, which reached an average of (2.11, 3.77) insects/10 leaf and (1.66, 2.66) insects/10 leaf for the 2nd spray respectively and for the nymphs at the 2nd spray after (1, 3, and 7) days, which reached an average of (8.66, 4.88, 3.88) nymph/16 cm2 respectively . The present results it shows the effectiveness of the biological agents used (bio-pesticide) and demonstrate that biological insecticides can be used in the management of whitefly by following safety instructions for the use of insecticides and choosing the right time to harvest the plants this is to avoid harm from pesticides as much as possible.
FEASIBILITY ANALYSIS OF URBAN SMALLHOLDER RICE FARMING IN BANGAKALA VILLAGE, MANGGALA DISTRICT, MAKASSAR CITY
Authors: Molla Saleh , Nurdin Nurdin 
Published: September 2023

Every business that carried out is expected to be sustainable. Businesses in the agricultural sector can continue if they can provide benefits to the management. The sustainability of a business in the agricultural sector can be seen in social economics and ecological sustainability. Economic sustainability can be seen in terms of economic feasibility, for example, being able to generate profit or income. While social sustainability is indicated by the existence of cooperation and the ability to minimize completeness among stakeholders, especially among fellow farming actors, while an Ecological sustainability farming business occurs when there is an effort among farming actors to conserve land and apply organic farming. This study aims to determine the feasibility of urban rice farming in Bangkala Village, Manggala District, Makassar City. Respondentd were chosen purposively sampling technique. While the data was analyzed by using B/C ratio. The results of the analysis of the B/C ratio obtained were 0.72, meaning that rice farming for urban farmers in the Bangkala sub-district, Manggala District, from an economic point of view, was no longer feasible or not longer profitable. Therefore farmers have to look for other sources of income such as becoming construction workers, sellers, or starting a business, so the government needs to intervene to provide training to build the skills needed by farmers.
MEMBER PERCEPTION OF CASSAVA FARMER GROUP PERFORMANCE IN SUNGAI BULUH UTARA VILLAGE, BATANG ANAI DISTRICT, PADANG PARIAMAN REGENCY
Authors: Muhammad Iqbal  , Arianti Nyayu Neti , M. Zulkarnain Yuliarso  
Published: September 2023

This research was conducted from January to February 2022 in Buluh Utara Village, Batang Anai District, Padang Pariaman Regency. The aim was to analyze members' perceptions of the performance of cassava farmer group. The number of farmer group members in Sungai Buluh Utara Village is 119 cassava farmers who are from four farmer group, namely the Women Farmer Group (Kelompok Wanita Tani, KWT) of Kampung Apar, Kampung Apar, Maju Sepakat and Harapan Baru. The number of respondents was 54 people obtained by the Slovin formula and taken proportionally from each farmer group. The performance of farmer group assessed by members includes the role or function of farmer group as Learning Classes, Cooperation Forums and Production Units. Farmers' perceptions of the performance of farmer group were measured using a Likert scale and then grouped into three categories namely Not Good, Quite Good and Good. The results showed that most of the members (61.11%) gave the perception that the performance of the cassava farmer group as a Learning Class was in the good category, while for the Cooperation Forum r the majority (74.08) of the members rated it was less good and for the role as a Production Unit is also viewed as unfavorable by as many as 66.67% of members.