bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily stigma and daily emotional well‐being among people living with HIV: Testing a buffering hypothesis of social support during the COVID‐19 pandemic
Authors: Gruszczyńska Ewa , Rzeszutek Marcin 
Published: October 2023

AbstractThis study examined the relationship between daily perceived stigma and daily emotional well‐being among people living with HIV/AIDS during the COVID‐19 pandemic. Additionally, a buffering effect of perceived emotional support on this relationship was verified. The participants were 133 patients with a medically confirmed diagnosis of HIV infection. Data were collected using online diaries completed every evening for five consecutive weekdays in three bursts separated by 6 months. Dynamic multilevel analyses showed a significant positive autoregressive effect for daily stigma in each burst. Additionally, increased stigma predicts increased negative affect and decreased positive affect the next day. However, these effects differed across bursts. Thus, to some extent, daily HIV/AIDS stigma was found to predict a decrease in affective well‐being the next day. The buffering effect of perceived emotional support reduced this decline but was also time‐limited, probably because of the later established direction in these relationships at the individual level and/or because of changes in the course of the pandemic. The results provide insights on the role of daily stigma in shaping affective well‐being, suggesting that it may be a significant source of short‐term negative emotional consequences for PWLH.
Baseline circulating tumour DNA and interim PET predict response in relapsed/refractory classical Hodgkin lymphoma
Authors: Calabretta Eleonora , di Trani Martina , Corrado Francesco , Sollini Martina , Cristaldi Vanessa , Marino Fabrizio , Terzi di Bergamo Lodovico , Bruscaggin Alessio , Pirosa Maria Cristina , Bramanti Stefania , Chiti Arturo , Rossi Davide , Carlo‐Stella Carmelo 
Published: October 2023

SummaryReliable biomarkers for early identification of treatment failure in relapsed/refractory (r/r) classical Hodgkin lymphoma (cHL) are lacking. Circulating tumour DNA (ctDNA) profiling has emerged as a powerful predictive and prognostic tool in several haemopoietic and non‐haemopoietic malignancies and may guide rational treatment choices in r/r cHL. To assess the predictive and prognostic value of ctDNA, we performed a retrospective analysis on 55 r/r cHL patients treated with the bendamustine, gemcitabine and vinorelbine (BEGEV) regimen and additionally evaluated the potential utility of integrating ctDNA with interim [18F]‐FDG positron emission tomography (iPET). Baseline ctDNA genotyping in r/r cHL mirrored gene mutations and pathways involved in newly diagnosed cHL. We found that baseline ctDNA quantification and serial ctDNA monitoring have prognostic value in r/r cHL receiving salvage chemotherapy. Lastly, integrating ctDNA quantification with iPET evaluation may improve the early identification of patients at high risk of failing standard salvage therapy, who may benefit from an early switch to immunotherapeutic agents. Collectively, our results support the implementation of non‐invasive methods to detect minimal residual disease in recurrent cHL and justify its prospective evaluation in appropriately designed clinical trials.
PhylogeneticGraph (PhyG) a new phylogenetic graph search and optimization program
Authors: Wheeler Ward C. , Washburn Alexander , Crowley Louise M. 
Published: October 2023

AbstractWe present Phylogenetic Graph (PhyG), an open‐source, phylogenetic search tool for diverse data types and graphs, including softwired and hardwired networks, in addition to trees. This allows for analysis of horizontal transfer and hybridization scenarios, as well as the necessary vertical inheritance of trees. PhyG is the successor to POY5 in performing combined data tree‐alignment with enhancements in heuristic optimality (up to 7% in example data) and execution time (up to a factor of 200). Input data may exhibit a practically unlimited number of character states in qualitative or sequence (aligned and unaligned) types. Novel graph construction and refinement algorithms have been implemented and integrated into a variety of search procedures. Currently, PhyG implements parsimony and No‐Common‐Mechanism Likelihood optimization.
The BMDC model, a performant cell‐based test to assess the sensitizing potential and potency of chemicals including pre/pro‐haptens
Authors: Battais Fabrice , Langonné Isabelle , Muller Samuel , Mathiot Julianne , Coiscaud Amélie , Audry Adrien , Remy Aurélie Martin , Sponne Isabelle , Mourot‐Bousquenaud Mélanie 
Published: October 2023

AbstractBackgroundChemical‐induced allergies at workplace represent a significant occupational health issue. These substances must be properly identified as sensitizers. In previous studies, an original model using mouse bone marrow‐derived dendritic cells (BMDC) was developed for this purpose.ObjectivesThe aim of this study was to evaluate the predictive capacity of the BMDC model with a large panel of sensitizers (including pre‐ and pro‐haptens) and non‐sensitizers.MethodsThe readout from the BMDC model is based on expression levels of six phenotypic markers measured by flow cytometry.ResultsThe results indicate that 29 of the 37 non‐sensitizers, and 81 of the 86 sensitizers were correctly classified compared to the Local Lymph Node Assay (LLNA). Statistical analysis revealed the BMDC model to have a sensitivity of 94%, a specificity of 78%, and an accuracy of 89%. The EC2 (Effective Concentration) values calculated with this model allow sensitizers to be categorized into four classes: extreme, strong, moderate and weak.ConclusionsThese excellent predictive performances show that the BMDC model discriminates between sensitizers and non‐sensitizers with outstanding precision equal to or better than existing validated alternative models. Moreover, this model allows to predict sensitization potency of chemicals. The BMDC test could therefore be proposed as an additional tool to assess the sensitizing potential and potency of chemicals.
The Return of Debt Crisis in Developing Countries: Shifting or Maintaining Dominant Development Paradigms?
Authors: Fischer Andrew M. , Storm Servaas 
Published: October 2023

ABSTRACTIn the aftermath of the COVID‐19 pandemic, much of the global South has been immersed in a debt crisis of a breadth and depth not seen since the early 1980s. The debt distress was apparent before the pandemic and the situation over the last decade is best described as a slow burn, which the pandemic and war in Ukraine ignited in often sudden and dramatic ways. However, what remains a surprising feature of the ongoing situation has been the avoidance so far of a generalized domino effect, unlike previous systemic Southern debt crises. This fact does not diminish the severity of the consequences given that the containment of crisis has been achieved by regular and persistent applications of austerity and adjustment programmes with deleterious impacts on development in poor countries. This article frames the Debate by exploring these aspects of the current Southern debt crisis, focusing on its deeper structural drivers versus the role of more proximate triggers of the crisis; the similarities or differences with past crises of recent decades; and the degree to which anything has in fact changed in orthodox responses to crisis management. A theme that emerges from the more heterodox scholarship profiled by this Debate is that the current crisis and its responses are maintaining the dominant development paradigm of the last 40 years, rather than eliciting a shift away from it. There is a continued adherence to neoliberal ideology in macroeconomic policy making and to the punitive subordination of developing countries in debt distress, through crisis responses, to the Northern and especially US‐centred international financial system. Ignoring the very strong similarities to the past, especially the 1982 debt crisis that ushered in this paradigm, risks repeating the lost decades to development that followed.
Effects of enamel moistening and repositioning guide color on tooth whitening outcomes: A clinical trial
Authors: Santana Tauan Rosa , Silva Paula Fernanda Damasceno , Santana Márcia Luciana Carregosa , de Mattos Clara Lemos Leal Barata , Faria‐e‐Silva André Luis 
Published: October 2023

AbstractThis clinical trial investigated the effects of pre‐application enamel moistening on the impact of a 37% carbamide peroxide whitener on tooth color changes and the influence of repositioning guide colors. Forty participants were randomly assigned to in‐office tooth bleaching with either moistened enamel (experimental) or dry enamel (control). The whitener was applied for 45 min over two sessions. Tooth color was visually measured or assessed using a spectrophotometer with purple or green silicone guides. Tooth bleaching was assessed using CIE76 (ΔEab) and CIEDE2000 (ΔE00) formulas and by whitening and bleaching index score changes. Moistening the enamel did not significantly affect tooth color. However, the guide color choice only impacted tooth color when measured instrumentally. At baseline, the green guide resulted in statistically significantly whiter teeth than the purple guide. Less pronounced differences in the b* coordinate between baseline and final measurements were found using the green guide. The green guide also produced lower ΔEab values and less change in indexes. In conclusion, moistening the enamel did not significantly impact tooth color changes. However, the repositioning guide color influenced the tooth bleaching measured instrumentally, except for ΔE00.
Expression of the GCG gene and secretion of active glucagon‐like peptide‐1 varies along the length of intestinal tract in horses
Authors: Fitzgerald Danielle M. , Cash Christina M. , Dudley Kevin J. , Sibthorpe Poppy E. M. , Sillence Martin N. , de Laat Melody A. 
Published: October 2023

AbstractBackgroundActive glucagon‐like peptide‐1 (aGLP‐1) has been implicated in the pathogenesis of equine insulin dysregulation (ID), but its role is unclear. Cleavage of proglucagon (coded by the GCG gene) produces aGLP‐1 in enteral L cells.ObjectivesThe aim in vivo was to examine the sequence of the exons of GCG in horses with and without ID, where aGLP‐1 was higher in the group with ID. The aims in vitro were to identify and quantify the expression of GCG in the equine intestine (as a marker of L cells) and determine intestinal secretion of aGLP‐1.Study designGenomic studies were case–control studies. Expression and secretion studies in vitro were cross‐sectional.MethodsThe GCG gene sequence of the exons was determined using a hybridisation capture protocol. Expression and quantification of GCG in samples of stomach duodenum, jejunum, ileum, caecum and ascending and descending colon was achieved with droplet digital PCR. For secretory studies tissue explants were incubated with 12 mM glucose and aGLP‐1 secretion was measured with an ELISA.ResultsAlthough the median [IQR] post‐prandial aGLP‐1 concentrations were higher (p = 0.03) in animals with ID (10.2 [8.79–15.5]), compared with healthy animals (8.47 [6.12–11.7]), there was 100% pairwise identity of the exons of the GCG sequence for the cohort. The mRNA concentrations of GCG and secretion of aGLP‐1 differed (p < 0.001) throughout the intestine.Main limitationsOnly the exons of the GCG gene were sequenced and breeds were not compared. The horses used for the study in vitro were not assessed for ID and different horses were used for the small, and large, intestinal studies.ConclusionsDifferences in post‐prandial aGLP‐1 concentration were not due to a variant in the exons of the GCG gene sequence in this cohort. Both the large and small intestine are sites of GLP‐1 secretion.
The role of calcitonin gene‐related peptide and substance P in the pathogenesis of dialysis headache
Authors: Gürsoy Gizem , Karadağ Serhat , Köse Şennur , Şakacı Tamer , Koçak Sibel Yücel , Döventaş Yasemin Erdoğan , Oktar Ayla Çulha , Bayar Muhammet Duran 
Published: October 2023

AbstractAimThe present study aims to establish the role of serum CGRP and SP levels in the disease pathophysiology in patients with dialysis headache not accompanied by primary or secondary headaches, and also whether there is a correlation between these vasoactive peptides and the severity of headache.MethodThis study was designed as prospective and multicenter. A total of 30 dialysis headache patients and 30 patients without headache as the control group in the Nephrology outpatient clinics which implement similar dialysis procedures were included in the study. Blood samples were taken from all the patients before hemodialysis, and post‐hemodialysis samples were collected. CGRP and SP contents in serum samples were measured using the ELISA method with detection kits.ResultsA total of 60 patients were included in the study with 17 female and 13 male patients in the dialysis headache group and 18 female and 12 male patients in the control group, and there were no significant differences in sex and age between the groups. CGRP levels in the headache group were found to be significantly higher compared with the control group both before and after hemodialysis. Furthermore, pre‐hemodialysis CGRP levels were significantly higher than post‐hemodialysis CGRP levels in both the headache and control groups. Serum SP levels in the headache group were found to be higher compared with the control group both before and after hemodialysis, there was no significant difference between the groups. Even though SP levels in both groups decreased after hemodialysis, there was again no significant difference between the groups. No correlation was found between the patients' severity of headache and serum CGRP and SP levels.ConclusionThis study concludes that CGRP and SP, even though the latter is not statistically significant, play a role in the pathophysiology of the dialysis headache, and further studies with a larger and more specific patient population may reveal the relationship between the neuropeptides and dialysis headache more clearly.
CD45 limits early Natural Killer cell development
Authors: Meza Guzman Lizeth G , Hyland Craig D , Bidgood Grace M , Leong Evelyn , Shen Zihan , Goh Wilford , Rautela Jai , Vince James E , Nicholson Sandra E , Huntington Nicholas D 
Published: October 2023

AbstractThe clinical development of Natural Killer (NK) cell‐mediated immunotherapy marks a milestone in the development of new cancer therapies and has gained traction due to the intrinsic ability of the NK cell to target and kill tumor cells. To fully harness the tumor killing ability of NK cells, we need to improve NK cell persistence and to overcome suppression of NK cell activation in the tumor microenvironment. The trans‐membrane, protein tyrosine phosphatase CD45, regulates NK cell homeostasis, with the genetic loss of CD45 in mice resulting in increased numbers of mature NK cells. This suggests that CD45‐deficient NK cells might display enhanced persistence following adoptive transfer. However, we demonstrate here that adoptive transfer of CD45‐deficiency did not enhance NK cell persistence in mice, and instead, the homeostatic disturbance of NK cells in CD45‐deficient mice stemmed from a developmental defect in the progenitor population. The enhanced maturation within the CD45‐deficient NK cell compartment was intrinsic to the NK cell lineage, and independent of the developmental defect. CD45 is not a conventional immune checkpoint candidate, as systemic loss is detrimental to T and B cell development, compromising the adaptive immune system. Nonetheless, this study suggests that inhibition of CD45 in progenitor or stem cell populations may improve the yield of in vitro generated NK cells for adoptive therapy.
Trust in information mediates the relationship between political orientation and perceptions of the COVID‐19 pandemic
Authors: Dodd Bailey , Rife Sean 
Published: October 2023

AbstractThe past few decades have experienced a decline in the use of traditional news sources as an increasing number of individuals rely on social media for information. Although this change has made it easier to obtain information, individuals often selectively expose themselves to information that confirms their beliefs. The current study examined if this pattern could explain political perceptions during the COVID‐19 pandemic. Based on past research, it would be expected that liberals and conservatives would hold differing views of the COVID‐19 pandemic. Republicans downplayed the pandemic and were more likely to consider it a hoax, while Democrats exaggerated the pandemic and were more likely to advocate for excessive measures. In this study, we collected two samples at different points during the pandemic in which we asked participants to indicate their political ideology, their perception of the COVID‐19 pandemic, and the sources of information that they trusted. Our results indicated that trust in information sources mediated the relationship between political ideology and perceptions of the pandemic, suggesting that the informational sources that an individual trusted was a factor in determining perceptions of the COVID‐19 pandemic.
Listening to or looking at models: Learning about dynamic complex systems in science among learners who are blind and learners who are sighted
Authors: Peleg Ran , Lahav Orly , Hagab Noha , Talis Vadim , Levy Sharona T. 
Published: October 2023

AbstractBackgroundStudents who are blind are integrated into public schools in many countries, yet are often excluded from full participation in science since most learning materials are visual. To create a compensatory route, an existing model‐based inquiry‐learning environment was adapted by means of sonification (addition of non‐speech sounds that represent dynamic information). The learning environment uses agent‐based models and a complex systems approach to teach the Kinetic Molecular Theory (KMT) and Gas Laws. The models are accompanied by a workbook consisting of text (printed or auditory) and images (printed or tactile).ObjectivesThe current research examined whether such perceptual compensation creates a comparable learning environment for learners who are blind compared with learners who are sighted using the original learning environment. The aim of the study is to expand knowledge about how the auditory channel may compensate the visual channel among individuals who are blind.MethodsConceptual learning in science and reasoning about complex systems were assessed using pre‐ and post‐questionnaires. To explore learners' learning progression throughout the unit, four progression analysis ‘windows’ were selected. These were groups of adjacent or nearly adjacent items in the workbook that permitted a glimpse of learners' progression.ResultsThe sonified environment not only supported the learning of learners who are blind compared with the learning of learners who are sighted using visual material, but even furthered their learning with respect to diffusion, one of the more challenging concepts in KMT. It seems the types of sonified representations used in this study increased listeners' sensitivity to the micro‐level interactions in a way less accessible in visual representations.TakeawaysSonified environments can be provide learners who are blind with equitable participation by compensating and complementing the visual channel. Sonification can have implications for students who are blind as well as students who are sighted.
Firms’ Response to Slacktivism: When and Why are E‐Petitions Effective?
Authors: Leonel Ronei , Rehbein Kathleen , Westermann‐Behaylo Michelle , Perrault Elise 
Published: October 2023

AbstractE‐petitions have evoked an important debate about the potential for digital activism to pressure firms to change social policies and practices. One prevailing perspective is that slacktivism, a tendency of online supporters to provide only token support, undermines any possible impact. An alternative perspective is that social media dynamics underlying digital activism offer new pathways for social activists to pressure firms toward social change. To explore this debate, we combine insights from research on social movements, social media, and the logic of connective action to theorize the impact of social media mechanisms such as e‐petition connectivity and velocity. With a hand‐coded database of 1587 e‐petitions targeting Fortune 500 firms from 2012 to 2017 through the platform Change.org, we empirically evaluate whether these e‐petitions matter. Our empirical results strongly suggest that e‐petitions do matter, and we explain when digital activism has impact. The activation of social media mechanisms spreads negative information and directly intensifies the threat to the targeted firm's reputation, pressuring firms to concede to e‐petitioner demands. Furthermore, our findings indicate that firm visibility and resource availability can represent boundary conditions for the firm's vulnerability and ability to respond to digital activism.
Business model innovation: Integrative review, framework, and agenda for future innovation management research
Authors: Spieth Patrick , Breitenmoser Pascal , Röth Tobias 
Published: October 2023

AbstractThe business model innovation (BMI) concept has become a well‐established phenomenon of current academic research. While Foss and Saebi's (Journal of Management, 2017, 43, 200–227) seminal literature review on BMI revealed 349 articles on BMI published between 1972 and 2015, an additional number of 1727 articles on the topic have been published since 2016. In contrast to this overall interest in the BMI phenomenon, innovation‐focused journals include only a limited number of publications on BMI. Further, besides the valuable insights and fruitful research directions of extant literature reviews, they tend also to overlook the linkages between traditional innovation management and the majority of BMI research. Given this underrepresentation of BMI research in the innovation management literature, we conduct an integrative literature review to bring the disconnected literature closer together and offer directions for future research. Our literature review applies the review strategy of blending and merging the literature across domains. First, we blend the knowledge base of the BMI domain by applying the Product Development and Management Association (PDMA) Body of Knowledge categories. Second, we merge the literature across domains by developing an integrative framework. As recent BMI literature increasingly converged to two lines of research, our framework differentiates between the relatedness of the BMI and BMI openness. Thereby, we offer new avenues for future research that can enrich the dialogue on BMI research in the innovation management community. These results demonstrate how the BMI domain covers aspects that fit, contribute to, and extend classical innovation‐focused research, how both research domains can be merged to enrich each other, and how future research can foster the dialogue across disconnected domains.
Theology and Economy ‘after’ Barth
Authors: Michelson Jared 
Published: October 2023

AbstractThe relation of theology and economy is a perennial theological challenge. Many contemporary theologians' understanding of this challenge is shaped by Karl Barth's attempt to resolve a set of tensions problematising this relation inherited from figures like Kant and Feuerbach. Barth ‘identified’ God's decision to be God with God's decision to be human. Further, he inconsistently but insistently claimed that the ‘form’ in which God reveals Godself in the person of Jesus somewhat isomorphically corresponds to God in Godself. The brilliance and yet instability of Barth's approach spawned a number of construals of theology and economy which depart from him in significant ways. I label these contemporary trajectories the post‐Barthian temptation, Barthian revisionism, Barthian Balthasarianism, and Barthian catholicism and critically evaluate them, suggesting that Barthian catholicism is the most promising.