bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying Infrared Thermography to a Latest Residential Building in France: Case Study, Verifying Dwellings National Thermal Regulations RT 2012 Mainly Thermal Bridges Assessment
Authors: RAMENAH Harry 
Published: October 2023

High-performance insulation and airtight building envelopes are the two most important factors to optimize the building energy efficiency and thermal performance. However, thermal performance of building envelopes can be significantly affected by thermal bridging. Thermal bridges can take place at different locations of the building envelope, causing added transmission losses, increasing heat flow, lower inner surface temperatures. Thermal bridges are regarded in all national regulations for new buildings of all states of European Union (EU) but there are no specifications assessing balconies to wall junctions and the impact on the building thermal performance is not well regulated. In this paper, balcony to wall thermal bridge assessment using infrared thermography is highlighted. The originality is that, infrared thermography, has been applied to a real living latest building in the north east of France showing that there is noncompliance in the national regulations as some exigencies are not met. Thermography of thermal break windows and window doors has also revealed air leakage. The goal, is to illustrate that thermal imaging is a means of quality assurance to new building specifications and should include a clause specifying quality assurance procedure for balconies junction in national building regulations for all states if the EU.
Long-Term Outcomes of Nonsurgical Treatment of Thumb Carpometacarpal Osteoarthritis
Authors: Esteban Lopez Lisa M.J. , Hoogendam Lisa , Vermeulen Guus M. , Tsehaie Jonathan , Slijper Harm P. , Selles Ruud W. , Wouters Robbert M. ,   The Hand-Wrist Study Group
Published: October 2023

Background:
Although nonsurgical treatment of thumb carpometacarpal (CMC-1) osteoarthritis (OA) provides short-term improvement, the durability of these effects beyond 1 year is unknown. In this study, we investigated patient-reported pain and limitations in activities of daily living (ADL) at >5 years following nonsurgical treatment (i.e., exercise therapy and use of an orthosis) for CMC-1 OA. We hypothesized that pain and limitations in ADL would not worsen after 12 months. Secondary outcomes were satisfaction with treatment results and health-related quality of life at >5 years of follow-up and the rate of conversion to surgery.

Methods:
This was a multicenter, prospective cohort study using 2 overlapping samples. The change in the Michigan Hand Outcomes Questionnaire (MHQ) subscales of pain and ADL between 12 months and >5 years was the primary outcome as measured in the first sample (n = 170), which consisted of patients who did not undergo conversion to surgery. Additional measurement time points included baseline and 3 months. We evaluated conversion to surgery in a second sample, which included all patients who responded to the invitation for this follow-up study (n = 217).

Results:
At a median follow-up of 6.6 years (range, 5.1 to 8.7 years), the score on the MHQ pain subscale did not differ significantly from that at 12 months. The score on the MHQ ADL improved by 4.4 points (95% confidence interval [CI],1.5 to 7.2) compared with 12 months, but this was not clinically relevant. At >5 years, 5% of the patients rated their satisfaction as “poor,” 14% as “moderate,” 26% as “fair,” 39% as “good,” and 16% as “excellent.” The median EuroQol-5 Dimensions-5 Levels (EQ-5D-5L) index score was 0.852 (range, 0.135 to 1). The rate of conversion to surgery was 22% (95% CI,16.4% to 27.7%) at a median follow-up of 7 years (range, 5.5 to 9.0 years).

Conclusions:
We found positive outcomes at >5 years of follow-up for nonsurgical treatment of CMC-1 OA, with no worsening of pain or of limitations in ADL after 12 months. Our findings support nonsurgical treatment as the first treatment choice and suggest that treatment effects are sustainable.

Level of evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Practice for integrated teaching mode of basic and clinical medicine in topographical anatomy curriculum
Authors: Fang Xuan , Peng Xianlong , Liu Huaicun , Zhang Weiguang , Yan Junhao 
Published: October 2023

Abstract
Background To examine the effects of an integrated teaching mode on clinical medical students in a topographical anatomy curriculum.
Methods Clinical medical students were randomly divided into two groups. The students in the traditional teaching group completed a basic course only by the anatomy teachers, while those in the integrated group were taught by both anatomy teachers and clinical doctors with the aid of the AI virtual anatomy teaching system, clinical lectures and laparoscopic surgery simulation training.
Results Compared to those in the traditional group, the students in the integrated group achieved better outcomes in study habit development, knowledge acquisition capability and communication skills.
Conclusion The integrated teaching mode of basic and clinical medicine has significantly beneficial effects for students in mastering anatomical knowledge and cultivating early clinical concepts. Moreover, this pattern is also conducive to teaching and scientific research cooperation between anatomy teachers and clinical doctors.
Do non-steroidal anti-inflammatory drugs affect the release of GnRH via neuronal markers?
Authors: MAYTALMAN ERKAN , SAMUR Dilara NEMUTLU 
Published: October 2023

Abstract
Purpose
Some evidence that non-steroidal anti-inflammatory drugs have neuroprotective effects indicates their potential for use in a new field. However, its effects on hormone secretion have not been adequately discovered. Therefore, we aimed to evaluate the effects of dipyrone and indomethacin on neuronal markers as well as the GnRH expression in the GT1-7 cell line.
Methods
The effects of these drugs were evaluated by MTT analysis on proliferation. The effect of 10-50-250 µM concentrations of the drugs also on the expression of neuronal factors and markers, including NGF, nestin and βIII Tubulin, and additionally GnRH, was determined by the RT-qPCR method.
Results
NGF and nestin mRNA expressions were increased in all concentrations of both dipyrone and indomethacin. No changes were detected in βIII Tubulin. While dipyrone showed an increase in GnRH mRNA expression, there was no change at 10 and 50 µM concentrations of indomethacin, but a remarkable decrease was observed at 250 µM concentrations.
Conclusions
The results of our study showing an increase in the expression of neuronal factors reveal that dipyrone and indomethacin may have possible neuroprotective effects. Moreover, the effects on the GnRH expression appear to be different. Animal models are required to confirm these effects of NSAIDs on neurons.
Time-domain-filtered terahertz nanoscopy of intrinsic light-matter interactions
Authors: Hu Min , Zhang Xiaoqiuyan , Zhang Xin , Zhang Zhuocheng , Zhang Tianyu , Xu Xingxing , Tang Fu , Yang Jing , Wang Jiakun , Jiang Hui , Dun Zhaoyun , Wei Yanyu , Gong Yubin , Zhang Hui , Li Peining 
Published: October 2023

Abstract
Terahertz (THz) technology holds great potential across diverse applications including biosensing, security screening, and information communications, but its conventional far-field technique is diffraction-limited to submillimeter resolution. Near-field optical microscopy overcomes this barrier through a sharp metallized tip that concentrates incident THz waves into nanometric volumes, detecting the resulting scattered near-field to reveal nanoscale THz optical properties. However, owing to the large THz wavelengths, resonant surface waves arising on the tip and cantilever obscure the intrinsic near-field response. Here we combine near-field microscopy with THz time-domain spectroscopy and implement time-domain filtering with an elongated cantilever to eliminate this artifact, achieving intrinsic nanospectroscopy and nanoimaging at THz frequencies. By applying this technique, we distinguish and characterize of historical pigments of an ancient sculpture, such as vermilion and red lead, at the nanoscale. We also unravel deep-subwavelength localized resonance modes in THz optical antennas, demonstrating capabilities for THz nanophotonics. Our work advances THz nanoimaging and nanospectroscopy techniques to probe intrinsic nanoscale THz light–matter interactions.
Quality of home-based vaccination records: The case of Tamale Metropolis, Ghana
Authors: Konlan Matthew Yosah , Mahama Fuseini , Abubakari Braimah Baba , Appiah Benedict Ofori , Kubio Cynthia , Apea Porbilla Ofosu , Wilkins Karen A. , Kwarteng Peter Gyamfi , Abiwu Hilarius Asiwome Kosi 
Published: October 2023

Abstract
Objective:This study assessed the quality of vaccination cards in Tamale, Ghana. A cross-sectional study involving 1,398 pictures of vaccination cards taken during a cluster vaccination coverage survey in Tamale was used. Pictures that did not capture vaccination pages were excluded. We assessed the quality of pictures, the content and design of cards as well as quality of cards using criteria adapted from a previous study.
Results:Over 80% of cards fulfilled the picture quality criteria or card content criteria while over 90% met the card design criteria. However, none of the cards met the standard HBR criteria or had space for recording notes, known allergies and adverse events of immunization. Over 90% of cards did not have any physical damage, marks/hole punches/ staples that obstructed reading responses or evidently visible corrections. However, the spaces provided for responses and completion of cards require modification in future card design.
Global upper ocean oxygen budget and an observational constraint on the biological pump
Authors: Yamaguchi Ryohei , Kouketsu Shinya , Kosugi Naohiro , Ishii Masao 
Published: October 2023

Abstract

One mechanism by which the ocean absorbs and sequesters CO2 is through the fixation of inorganic carbon by biological production and its subsequent transport to the deep ocean, a process known as the biological carbon pump. Although the importance of the biological carbon pump in the global carbon cycle has long been recognized, estimation of its actual contribution to global ocean carbon uptake remains highly uncertain, challenging the observational constraints of current Earth system model simulations. Here we quantify global annual ocean carbon sequestration via the biological carbon pump by using dissolved oxygen data to estimate net biological oxygen production from an upper ocean oxygen budget calculation, leveraging the substantial increase in observational data provided by the recent expansion of Biogeochemical-Argo. The upper ocean oxygen budget, based on observational data, reveals a global balance between net oxygen removal due to physical processes (air–sea exchange, advection, and diffusion) and net oxygen production driven by biological activities. We converted the derived annual net biological oxygen production into annual net community production using the photosynthetic oxygen:carbon ratio, and inferred an estimated global oceanic carbon uptake by the biological pump of 6.15 ± 0.75 Pg C y− 1.
Karst fissures mitigate the negative effects of drought on plant growth and photosynthetic physiology
Authors: Luo Jie , Luo Weixue , Liu Junting , Wang Yongjian , Li Zongfeng , Tao Jianping , Liu Jinchun 
Published: October 2023

Abstract

Hard limestone substrates, which are extensively distributed, are believed to exacerbate drought and increase the difficulty of restoration in vulnerable karst regions. Fissures in such substrates may alleviate the negative effect of drought on plants, but the underlying mechanisms are remains poorly understood. In a two-way factorial block design, the growth and photosynthesis of two-year-old Phoebe zhennan seedlings were investigated in two water availabilities (W100% and W30%) and three stimulated fissure habitat groups: control soil habitat (S group, CK), soil-filled fissure habitat (SF group), and non-soil-filled fissure habitat (F group). Moreover, the fissure treatments included both small and large fissures. Compared to S group, F group decreased the total biomass, root biomass, total root length, and the root length of fine roots in the soil layer at both water availabilities, but increased photosynthetic rate (Pn) and remained at stable water use efficiency (WUE) at W30%. However, there was no significant differences between SF group and S group in the biomass accumulation and allocation as well as Pn. Nevertheless, the SF group lowered the root distribution in total and in the soil layer, also increased WUE at W30%. Across all treatments, fissure sizes had no effect on plant growth or photosynthesis. Karst fissures filled with soil can alleviate drought impacts on plant root growth, which involves adjusting root distribution strategies and increasing water use efficiency. Rock fissures can be involved in long-term plant responses to drought stress and vegetation restoration in rocky mountain environments under global climate change.
Availability and quality of primary health care in the compulsory health insurance system in Kazakhstan
Authors: Shurenova Mahabbat , Kurakbayev Kuralbay , Abildaev Tleukhan , Tazhieva Aigul 
Published: October 2023

Abstract

Background
The study aimed to assess the satisfaction of patients with primary health care services and to determine indicators of the effectiveness of medical care in the compulsory health insurance system in Kazakhstan.
Methods
It was an analytical observational study with cross-examination. This study was conducted in primary health care (PHC) organizations in Kazakhstan. Patient satisfaction was measured using a questionnaire consisting of 35 closed questions. The analysis of the indicators of the results of the stimulating component of the per capita standard for financing PHC organizations for the achieved results of activities is carried out.
Results
54.0% (1.80 ± 1.108) of the surveyed patients were completely satisfied with medical care, and 59.4% (1.82 ± 1.269) considered laboratory tests available. Men were completely satisfied with the medical care and availability of laboratory tests compared to women. Indicators of the final result were achieved in the city polyclinics № 3 and № 14 of the city of Almaty Kazakhstan and there was an increase in the amount of incentive component of per capita funding by 1.1 times.
Conclusions
In the system of compulsory medical insurance, medical care in PHC organizations is affordable and effective according to the estimates of the interviewed patients and an indicator of the final result of the polyclinics.
Comparison of Efficacy and safety of Tinapeg® vs. Neulastim® to prevent chemotherapy-induced neutropenia in breast cancer patients: randomized, parallel, equivalence, multicentric and Phase III clinical trial study
Authors: Mousavi Seied Asadollah , Servatian Nazli , Omidvar Shahryar , Amini Hossein , Afshari Mohammadali , Taghavi Behnam , Fumani Hosein Kamranzadeh , Vaezi Mohammad , Tavakoli Sahar , Nejad Nafiseh Ansari , Khodakarim Nastaran , Fardad Farshid , Rezvani Alireza , Namdari Nasrin , Poorkhani Amirhoushang , Naeimi-Tabiei Mohammad , Razavi Seyed Mohsen , Adib-Sereshki Mohammad Mahdi , Kaveh Vahid , Keshtkar Abbasali , Shahbazi Majid 
Published: October 2023

Abstract
Background
This study investigated the efficacy and safety of Pegylated recombinant human granulocyte colony-stimulating factor (PEG‐rhGCSF) manufactured by Arya Tina gene company in the preventing chemotherapy-induced neutropenia in breast cancer patients.
Methods
This study was designed as a parallel, randomized, double- blind, multicenter, and Phase III clinical trial. In this way, patients diagnosed with breast cancer who entered the study were randomly assigned into two groups. Fifty-one patients were randomly assigned to the Neulastim®, and 51 patients were assigned to the Tinapeg®. Each patient received a chemotherapy regimen containing doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2 on day 1, and 24 hours after (the second day), a single 6 mg dose of pegfilgrastim was administered subcutaneously. The primary endpoint was a rate of neutropenia during chemotherapy. The secondary endpoints were the incidence of febrile neutropenia, fever without neutropenia and its severity, occurrence of blood disorders, and rates of adverse events.
Results
Based on the results, at the end of the fourth cycle, the mean neutrophil counts in Tinapeg® and Neulastim® therapy groups increased by 26 and 34%, respectively, which was not statistically significant. Also, in the fourth cycle, the mean number of neutrophils in the Tinapeg® and Neulastim® therapy groups were 5315 and 5159; There was no significant difference between the two groups regarding the incidence of adverse events and unwanted reactions.
Conclusions
It was concluded that Tinapeg® and Neulastim® showed no clinically meaningful differences regarding efficacy and safety in breast cancer patients receiving chemotherapy.
Clinical trial registrations: IRCT2017061234487N1; Iranian Registry of Clinical Trials (IRCT)
https://www.irct.ir/trial/26341
Source of SARS-CoV-2 infection: results from a series of 584,846 cases in France from October 2020 to August 2022
Authors: Rakover Arthur , Galmiche Simon , Charmet Tiffany , Chény Olivia , Omar Faïza , David Christophe , Martin Sophie , Mailles Alexandra , Fontanet Arnaud 
Published: October 2023

Abstract
Background
We aimed to study the source of infection for recently SARS-CoV-2-infected individuals from October 2020 to August 2022 in France.
Methods
Participants from the nationwide ComCor case-control study who reported recent SARS-CoV-2 infection were asked to document the source and circumstances of their infection through an online questionnaire. Multivariable logistic regression was used to identify the factors associated with not identifying any source of infection.
Results
Among 584,846 adults with a recent SARS-CoV-2 infection in France, 46.9% identified the source of infection and an additional 22.6% suspected an event during which they might have become infected. Known and suspected sources of infection were household members (30.8%), extended family (15.6%), work colleagues (15.0%), friends (11.0%), and possibly multiple/other sources (27.6%). When the source of infection was known, was not a household member, and involved a unique contact (n = 69,788), characteristics associated with transmission events were indoors settings (91.6%), prolonged (> 15 min) encounters (50.5%), symptomatic source case (64.9%), and neither the source of infection nor the participant wearing a mask (82.2%). Male gender, older age, lower education, living alone, using public transportation, attending places of public recreation (bars, restaurants, nightclubs), public gatherings, and cultural events, and practicing indoor sports were all independently associated with not knowing the source of infection.
Conclusion
Two-thirds of infections were attributed to interactions with close relatives, friends, or work colleagues. Extra-household indoor encounters without masks were commonly reported and represented avoidable circumstances of infection.
Trial registration
ClinicalTrials.gov registration number: NCT04607941
Assessing Calibration and Bias of a Deployed Machine Learning Malnutrition Prediction Model within a Large Healthcare System
Authors: Liou Lathan , Scott Erick , Parchure Prathamesh , Ouyang Yuxia , Egorova Natalia , Freeman Robert , Hofer Ira , Nadkarni Girish , Timsina Prem , Kia Arash , Levin Matthew 
Published: October 2023

Abstract

Introduction
Malnutrition is a frequently underdiagnosed condition leading to increased morbidity, mortality and healthcare costs. The Mount Sinai Health System (MSHS) deployed a machine learning model (MUST-Plus) to detect malnutrition upon hospital admission. However, in diverse patient groups a poorly calibrated model may lead to misdiagnosis, exacerbating health care disparities. We explored the model’s calibration across different variables and methods to improve calibration.
Methods
Data from adult (age > 18) patients admitted to 5 MSHS hospitals from September 20, 2020 - December 31, 2021 were analyzed. We compared MUST-Plus prediction to the registered dietitian’s formal assessment. We assessed calibration following the hierarchy of weak, moderate, and strong calibration. We tested statistical differences in intercept and slope by bootstrapping with replacement.
Results
We included 49,282 patients (mean age = 66.0). The overall calibration intercept was − 1.25 (95% CI: -1.28, -1.22), and slope was 1.55 (95% CI: 1.51, 1.59). Calibration was not significantly different between White and Black patients. The calibration intercept was significantly different between male and female patients. Both calibration intercepts and slopes were statistically different between 2021 and 2022. Recalibration improved calibration of the model across race, gender, and year.
Discussion
The calibration of MUST-Plus underestimates malnutrition in females compared to males, but demonstrates similar calibration slope, suggesting similar distributions of risk estimation. Recalibration is effective at reducing miscalibration across all patient subgroups. Continual monitoring and timely recalibration can improve model accuracy.
The Radiolabeling of [161Tb]-PSMA-617 by a Novel Radiolabeling Method and Preclinical Evaluation by In Vitro/In Vivo Methods.
Authors: UYGUR EMRE , Sezgin Ceren , Parlak Yasemin , Karatay Kadriye Busra , Arikbasi Bilal , Avcibasi Ugur , Toklu Turkay , Barutca Sabri , Harmansah Coskun , Sozen Tevfik Sinan , Maus Stephan , Scher Howard , Aras Omer , Gumuser Fikriye Gul , Muftuler Fazilet Zumrut Biber 
Published: October 2023

Abstract
Background
Prostate cancer (PC) is the most common type of cancer in elderly men, with a positive correlation with age. As resistance to treatment has developed, particularly in the progressive stage of the disease and in the presence of microfocal multiple bone metastases, new generation radionuclide therapies have emerged. Recently, [161Tb], a radiolanthanide introduced for treating micrometastatic foci, has shown great promise for treating prostate cancer.
Results
In this study, Terbium-161 [161Tb]Tb was radiolabeled with prostate-specific membrane antigen (PSMA)-617 ([161Tb]-PSMA-617) and the therapeutic efficacy of the radiolabeled compound investigated in vitro and in vivo. [161Tb]-PSMA-617 was found to have a radiochemical yield of 97.99 ± 2.01% and was hydrophilic. [161Tb]-PSMA-617 was also shown to have good stability, with a radiochemical yield of over 95% up to 72 hours. In vitro, [161Tb]-PSMA-617 showed a cytotoxic effect on LNCaP cells but not on PC-3 cells. In vivo, scintigraphy imaging visualized the accumulation of [161Tb]-PSMA-617 in the prostate, kidneys, and bladder.
Conclusions
The results suggest that [161Tb]-PSMA-617 can be an effective radiolabeled agent for the treatment of PSMA positive foci in prostate cancer.