bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased grey matter volume in dorsolateral prefrontal cortex and thalamus accompanied by compensatory increases in middle cingulate gyrus of premature ejaculation patients
Authors: Gao Songzhan , Chen Jianhuai , Liu Jia , Guan Yichun , Liu Rusheng , Yang Jie , Yang Xianfeng 
Published: October 2023

AbstractIntroductionThe prefrontal–cingulate–thalamic areas are associated with ejaculation control. Functional abnormalities of these areas and decreased grey matter volume (GMV) in the subcortical areas have been confirmed in premature ejaculation (PE) patients. However, no study has explored the corresponding GMV changes in the prefrontal–cingulate–thalamic areas, which are considered as the important basis for functional abnormalities. This study aimed to investigated whether PE patients exhibited impaired GMV in the brain, especially the prefrontal–cingulate–thalamic areas, and whether these structural deficits were associated with declined ejaculatory control.MethodsT1‐weighted structural magnetic resonance imaging (MRI) data were acquired from 50 lifelong PE patients and 50 age‐, and education‐matched healthy controls (HCs). The PE diagnostic tool (PEDT) was applied to assess the subjective symptoms of PE. Based on the method of voxel‐based morphometry (VBM), GMV were measured and compared between groups. In addition, the correlations between GMV of brain regions showed differences between groups and PEDT scores were evaluated in the patient group.ResultsPE patients showed decreased GMV in the right dorsolateral superior frontal gyrus (clusters = 13, peak T‐values = −4.30) and left thalamus (clusters = 47, T = −4.33), and increased GMV in the left middle cingulate gyrus (clusters = 12, T = 4.02) when compared with HCs. In the patient group, GMV of the left thalamus were negatively associated with PEDT scores (r = −0.35; P = 0.01). Receiver operating characteristic (ROC) analysis showed that GMV of the right dorsolateral superior frontal gyrus (AUC = 0.71, P < 0.01, sensitivity = 60%, specificity = 78%), left thalamus (AUC = 0.72, P < 0.01, sensitivity = 92%, specificity = 46%) and middle cingulate gyrus (AUC = 0.69, P < 0.01, sensitivity = 50%, specificity = 90%), and the combined model (AUC = 0.84, P < 0.01, sensitivity = 78%, specificity = 80%) all had the ability to distinguish PE patients from HCs.ConclusionDisturbances in GMV were revealed in the prefrontal–cingulate–thalamic areas of PE patients. The findings implied that decreased GMV in the dorsolateral prefrontal cortex and thalamus might be associated with the central pathological neural mechanism underlying the declined ejaculatory control while increased GMV in the middle cingulate gyrus might be the compensatory mechanism underlying PE.
Using priority effects for grassland restoration: Sequential sowing can promote subordinate species
Authors: Durbecq Aure , Bischoff Armin , Buisson Elise , Corcket Emmanuel , Jaunatre Renaud 
Published: October 2023

AbstractAimsThe influence of priority effects on plant community succession is increasingly discussed in community ecology. However, most grassland restoration approaches involving seed addition transfer all target species at the same time. Our objective was to tackle the question: does the order of arrival influence the establishment of restored communities?LocationLa‐Bâtie‐Neuve, Southern Alps, France.MethodsWe applied sequential sowing using two groups, one set of dominant species and one set of subordinate species, each comprising three different perennial plant species. We tested four sowing treatments: control (without any sowing), two sequential sowing treatments (dominants first or subordinates first) and synchronous sowing. We analysed plant cover each year for three years after sowing and calculated priority and earliness indices (the third year) for each group and each sown species.ResultsManipulating the order of arrival shaped community composition and trajectories. Some species of both groups were positively affected by being sown first compared to being sown synchronously. However, dominant and subordinate groups differed in their earliness index, showing a significant benefit for subordinates to be sown first. The subordinate species Onobrychis viciifolia and Plantago lanceolata established only when they were sown first, while Festuca cinerea showed greater establishment when sown first and simultaneously, compared to late sowing. The dominant Anthyllis vulneraria was not affected by date or type of sowing. However, the cover of the most dominant Bromopsis erecta was lower when being sown second, allowing a control of its dominance by delayed sowing.ConclusionThe strength of priority effects differs between species, which may depend on niche characteristics or microenvironment, influencing (negatively or positively) the establishment of late‐arriving species and affecting their competitive abilities. Our study provides evidence that plant community assembly was influenced by the order of arrival, but demonstrated a strong species‐specific response to priority effects.
Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia
Authors: Greite Robert , Schott Sebastian , Wang Li , Gohlke Lukas , Kreimann Kirill , Derlin Katja , Gutberlet Marcel , Schmidbauer Martina , Leffler Andreas , Tudorache Igor , Salman Jawad , Ius Fabio , Natanov Ruslan , Fegbeutel Christine , Haverich Axel , Lichtinghagen Ralf , Hüsing Anne M. , von Vietinghoff Sibylle , Schmitt Roland , Shushakova Nelli , Rong Song , Haller Hermann , Schmidt‐Ott Kai M. , Gram Magnus , Vijayan Vijith , Scheffner Irina , Gwinner Wilfried , Immenschuh Stephan 
Published: October 2023

AbstractFree heme is released from hemoproteins during hemolysis or ischemia reperfusion injury and can be pro‐inflammatory. Most studies on nephrotoxicity of hemolysis‐derived proteins focus on free hemoglobin (fHb) with heme as a prosthetic group. Measurement of heme in its free, non‐protein bound, form is challenging and not commonly used in clinical routine diagnostics. In contrast to fHb, the role of free heme in acute kidney injury (AKI) after cardiopulmonary bypass (CPB) surgery is unknown. Using an apo‐horseradish peroxidase‐based assay, we identified free heme during CPB surgery as predictor of AKI in patients undergoing cardiac valve replacement (n = 37). Free heme levels during CPB surgery correlated with depletion of hemopexin (Hx), a heme scavenger‐protein. In mice, the impact of high levels of circulating free heme on the development of AKI following transient renal ischemia and the therapeutic potential of Hx were investigated. C57BL/6 mice were subjected to bilateral renal ischemia/reperfusion injury for 15 min which did not cause AKI. However, additional administration of free heme in this model promoted overt AKI with reduced renal function, increased renal inflammation, and reduced renal perfusion on functional magnetic resonance imaging. Hx treatment attenuated AKI. Free heme administration to sham operated control mice did not cause AKI. In conclusion, free heme is a predictor of AKI in CPB surgery patients and promotes AKI in transient renal ischemia. Depletion of Hx in CPB surgery patients and attenuation of AKI by Hx in the in vivo model encourage further research on Hx therapy in patients with increased free heme levels during CPB surgery.
Effects of vagus nerve stimulation on the quality of sleep and sleep apnea in patients with drug‐resistant epilepsy: A systematic review
Authors: Seth Jayant , Couper R. Grace , Burneo Jorge G. , Suller Marti Ana 
Published: October 2023

AbstractObjectiveThe objective was to systematically evaluate the current evidence surrounding the effect of vagus nerve stimulation (VNS) on quality of sleep and obstructive sleep apnea (OSA) among patients with epilepsy.MethodsA literature search was conducted using the Embase and MEDLINE databases. Studies were included if they involved patients with drug‐resistant epilepsy treated with VNS and used validated tools to report on quality of sleep or sleep apnea. The literature search yielded 112 citations related to VNS and sleep quality, and 82 citations related to sleep apnea. Twelve articles were included in the review, of which five measured quality of sleep among patients who underwent VNS, six studies measured sleep apnea, and one study measured both outcomes.ResultsStudies measuring quality of sleep used different methods, including sleep quality questionnaires and the percentage of sleep in each cycle. Studies also varied in patient populations, the use of control groups, and whether multiple measurements were taken for each patient. Some studies found improved sleep quality after VNS, whereas others found reductions in deep sleep stages. Additionally, mixed results in sleep quality were found when comparing patients with epilepsy who received VNS treatment versus patients with epilepsy who did not receive VNS treatment. Variables such as VNS intensity and age could potentially confound quality of sleep. Studies measuring sleep apnea consistently found increased proportions of patients diagnosed with OSA or increased sleep index scores after VNS implantation.SignificanceOverall, the effect of VNS on quality of sleep remains unclear, as studies were very heterogeneous, although the effect on sleep apnea has consistently shown an increase in sleep apnea severity indices after VNS implantation. Future studies with consistent measures and discussions of confounding are required to determine the effect of VNS on quality of sleep, and the effect of VNS parameters should be further explored among patients who develop sleep apnea.
Longitudinal associations between the quality of family interactions and school‐age children's narrative abilities in the context of financial insecurity
Authors: Sabourin‐Guardo Éléonore , Miljkovitch Raphaële , Bernier Annie , Cyr Chantal , St‐Laurent Diane , Dubois‐Comtois Karine 
Published: October 2023

AbstractThis longitudinal study investigates whether the quality of family interactions at 3–5 years of age predicts narrative abilities in 7–9‐year‐old children from socioeconomically disadvantaged families. The sample consists of 67 children and their parents receiving social welfare. Family interactions were filmed during mealtime at home and coded using the Mealtime Interaction Coding System. Children's narrative abilities were measured based on their capacity to coherently elaborate and resolve stories from the Attachment Story Completion Task. Results revealed that children exposed to family interactions of higher quality make their narratives more accessible and understandable and include more appropriate expression of affects in their stories 4 years later, even after accounting for maternal education and verbal abilities. The results of this study highlight the importance of considering family interactions in the context of financial insecurity when studying socioemotional competence in childhood.
Indirect treatment comparisons of the gene therapy etranacogene dezaparvovec versus extended half‐life factor IX therapies for severe or moderately severe haemophilia B
Authors: Klamroth Robert , Bonner Ashley , Gomez Keith , Monahan Paul E. , Szafranski Kirk , Zhang Xiang , Walsh Sarah , Wang Di , Yan Songkai 
Published: October 2023

AbstractIntroductionEtranacogene dezaparvovec gene therapy for haemophilia B demonstrated superior efficacy at 24 months in reducing bleeds versus a ≥6‐month lead‐in period of prophylaxis with FIX products in the phase 3 trial, HOPE‐B. In the absence of head‐to‐head comparisons of etranacogene dezaparvovec versus FIX products, indirect treatment comparisons (ITC) can be used.AimTo compare the efficacy of etranacogene dezaparvovec versus rIX‐FP, rFIXFc and N9‐GP using ITC, and support HOPE‐B results.MethodsData were leveraged from Phase 3 pivotal trials: HOPE‐B, PROLONG‐9FP, B‐LONG and Paradigm 2. Annualised bleeding rates (ABR), spontaneous (AsBR) and joint (AjBR) bleeding rates, percentage of patients with no bleeds, and FIX consumption were assessed using inverse probability of treatment weighting and matching adjusted indirect comparisons.ResultsEtranacogene dezaparvovec demonstrated statistically significantly lower bleeding rates versus all comparators. Rate ratios for ABR, AsBR and AjBR versus rIX‐FP were 0.19 (p < .0001), 0.08 (p < .0001) and 0.09 (p < .0001), respectively. Rate ratios for ABR, AsBR and AjBR versus rFIXFc were 0.14 (p < .0001), 0.13 (p = .0083) and 0.15 (p = .0111), respectively. Rate ratios for ABR and AsBR, versus N9‐GP were 0.24 (p = .0231) and 0.13 (p = .0071), respectively. Etranacogene dezaparvovec demonstrated significantly higher percentage of patients with no bleeds versus rIX‐FP and rFIXFc; odds ratios: 17.60 (p < .0001) and 5.65 (p = .0037), respectively. Etranacogene dezaparvovec resulted in significantly lower FIX consumption than all comparators.ConclusionsITC suggests that etranacogene dezaparvovec offers patients with haemophilia B (≤2% of normal FIX expression) a single dose treatment that can significantly reduce bleeding rates and eliminate routine infusions associated with FIX therapies.
A comprehensive review on the antioxidant activities and health benefits of microgreens: current insights and future perspectives
Authors: Tallei Trina Ekawati , Kepel Billy Johnson , Wungouw Herlina Inneke Surjane , Nurkolis Fahrul , Adam Ahmad Akroman , Fatimawali  
Published: October 2023

SummaryMicrogreens contain an abundance of antioxidants (glucosinolates, carotenoids, and phenolic compounds), vitamins (C, E, and K), minerals (iron and magnesium), and other nutrients (fibre and omega‐3 fatty acids). They have been shown to promote cardiovascular health, reduce inflammation, combat cancer, manage diabetes, protect the nervous system, and improve digestion. This review investigates the antioxidant content and health implications of microgreens, providing current insights and prospective outlooks. The types of antioxidants found in microgreens, as well as the factors that influence their content, such as species, growing conditions, and harvesting time, are discussed. The review highlights antioxidants' role in cardiovascular health, inflammation reduction, cancer defence, diabetes management, and nervous system protection. The antioxidant properties of microgreen varieties are discussed. The bioavailability of antioxidants from microgreens, culinary applications, and incorporation into the diet are elaborated. The section of future perspectives covers the commercial potential of microgreens, optimal harvest timing, research directions, and potential functional food and nutraceutical uses. The aim and scope of this review are to provide a comprehensive understanding of the antioxidant content in microgreens and their associated health benefits. It also seeks to identify gaps in current research and suggest avenues for future studies, especially concerning their relevance in human health and nutrition.
Continuing education for advanced practice nurses: A scoping review
Authors: Wright Mea Mirella Marjatta , Kvist Tarja Anneli , Imeläinen Sanna Marika , Jokiniemi Krista Susanna 
Published: October 2023

AbstractAimThe aim of the study was to identify the nature and extent of scientific research addressing continuing education for advanced practice nurses.DesignA scoping review.Review MethodsThe Joanna Briggs Institute's methodology for scoping reviews.Data SourcesElectronic search was conducted on 17 September 2023 via CINAHL, PsycINFO, PubMed, Scopus, Web of Science, Cochrane Library and the Joanna Briggs Institute's Evidence‐Based Practice Database for research articles published between 2012 and 2023.ResultsNineteen papers were included in this review. Scientific research on continuing education for advanced practice nursing roles (i.e. nurse practitioner, clinical nurse specialist) has primarily been conducted in the United States and mostly addresses online‐delivered continuing education interventions for clinical care competency. Most of the interventions targeted nurse practitioners.ConclusionContinuing education has a pivotal role in supporting advanced practice nursing competency development. In addition to clinical care, future continuing education research should focus on other advanced practice nursing competencies, such as education, leadership, supporting organizational strategies, research and evidence implementation.Implications for the Profession and/or Patient CareContinuing education programmes for advanced practice nurses should be rigorously developed, implemented and evaluated to support the quality and effectiveness of patient care.ImpactContinuing education for advanced practice nursing roles is an understudied phenomenon. This review highlights future research priorities and may inform the development of continuing education programmes.Reporting MethodPRISMA‐ScR.
Obesity, diabetes and their metabolic correlates in middle‐aged adults with Down syndrome
Authors: Luchsinger J. A. , Pang D. , Krinsky‐McHale S. J. , Schupf N. , Lee J. H. , Silverman W. , Zigman W. B. 
Published: October 2023

AbstractBackgroundObesity in adults without Down syndrome is associated with an adverse metabolic profile including high prevalence of pre‐diabetes and diabetes, high levels of insulin, non‐high‐density lipoprotein (HDL) cholesterol, leptin and high‐sensitivity C‐reactive protein (hsCRP) and low levels of HDL and adiponectin. We examined whether obesity in middle‐aged adults with Down syndrome is also related to an adverse metabolic profile.MethodsThis cross‐sectional study included 143 adults with Down syndrome, with a mean age of 55.7 ± 5.7 years and 52.5% women. Body mass index (BMI) was classified as underweight (BMI < 18.5 kg/m2), normal (BMI 18.5–24.9 kg/m2), overweight (BMI 25–29.9 kg/m2) and obese (BMI ≥ 30 kg/m2). Diabetes was ascertained by history or by haemoglobin A1c (HbA1c) as normal glucose tolerance (HbA1c < 5.7%), pre‐diabetes (HbA1c 5.7–6.4%) and diabetes (HbA1c ≥ 6.5%). We measured non‐fasting lipids, hsCRP, insulin, adiponectin and leptin.ResultsThe majority of the sample had an overweight (46.9%) or obesity (27.3%) status. However, there was a relatively low prevalence of pre‐diabetes (9.8%) and diabetes (6.9%). Overweight and obesity status were not associated with lower HDL and adiponectin and higher insulin, non‐HDL cholesterol and hsCRP as expected in adults without Down syndrome. However, overweight and obesity were strongly associated with higher leptin (P < 0.001).ConclusionsThe only metabolic correlate of obesity in middle‐aged adults with Down syndrome was high leptin levels. Our findings are limited by non‐fasting laboratory tests but suggest that middle‐aged adults with Down syndrome do not have the adverse metabolic profile related to obesity found in adults without Down syndrome.
Increased risk of dementia differs across cardiovascular diseases and types of dementia – Data from a nationwide study
Authors: Kauko Anni , Engler Daniel , Niiranen Teemu , Ortega‐Alonso Alfredo , Schnabel Renate B. 
Published: October 2023

AbstractAimsDementia is a major health problem. Cardiovascular diseases (CVD) and risk factors are associated with incident dementia. However, whether there is an association among CVD, Alzheimer's disease (AD) and vascular dementia (VD) at the population level remains unclear.MethodsWe analysed the association between CVD (heart failure [HF], atrial fibrillation [AF], myocardial infarction [MI], peripheral arterial disease, stroke and transient ischemic attack) and the incidence of dementia using nationwide FinnGen data of 218,192 individuals. The last follow‐up information on dementia was available from October 2021.ResultsThe age at the end of the follow‐up was 61.7 ± 17.1 years, and 53% were women. Overall, we observed 9701 (4.4%) dementia, 6323 (2.9%) AD and 1918 (0.7%) VD cases. Individuals with CVD had a higher risk of developing dementia than unexposed individuals. In the multivariable‐adjusted Cox models, stroke was most strongly associated with dementia (hazard ratio [HR] 1.7, 95% confidence interval [CI] 1.6–1.8). CVD was more strongly associated with VD than with AD. Individuals with HF and MI had an increased risk of AD (HF: HR 1.11, 95% CI 1.04–1.19; MI: HR 1.10, 95% CI 1.02–1.18). AF was associated with VD (HR 1.58, 95% CI 1.42–1.77), but not with AD (HR 1.03, 95% CI 0.97–1.09). Clinical characteristics, such as diabetes, smoking and alcohol abuse, were associated with both types of dementia.ConclusionAll major CVDs were associated with an increased risk of developing dementia, particularly VD. Therefore, CVD onset should prompt an assessment of cognitive decline and possible preventive measures.
Double auction for trading perfect complements
Authors: Chaturvedi Rakesh , Pandey Ashish Kumar 
Published: October 2023

AbstractFor a trading problem where a buyer is interested in an aggregate resource with fragmented ownership, the individually owned resources are perfect complements in trade. A double auction, chosen in accordance with a value alignment principle which we formulate, is shown to be strategy proof for owners. Since it also values the aggregate resource correctly, it mitigates the holdout problem by changing the source of inefficiency from complementarity on owners' side to lack of competition on buyer side. The value alignment principle implies that this double auction has a majority trading rule. With multiple buyers, a suitable modification makes the double auction strategy proof even for the buyers, thus mitigating the holdout problem by achieving approximate ex post efficiency when the number of owners is large.