bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum afamin and its implications in adult growth hormone deficiency: a prospective GH-withdrawal study
Authors: Ratku Balázs , Lőrincz Hajnalka , Csiha Sára , Sebestyén Veronika , Berta Eszter , Bodor Miklós , Nagy Endre V. , Szabó Zoltán , Harangi Mariann , Somodi Sándor 
Published: February 2024

IntroductionAdult growth hormone deficiency (AGHD) is associated with a high prevalence of metabolic syndrome (MS), which contributes to the unfavorable cardiovascular risk profile in these patients. Insulin like growth factor-1 (IGF-1) is a widely used biomarker, however it does not always reflect the cardiometabolic risk and has a poor relationship with clinical efficacy endpoints. Consequently, there is an unmet need for biomarkers to monitor responses to GH-replacement. Afamin is a hormone-like glycoprotein, expressed in the liver. Higher afamin levels are strongly associated with MS and insulin resistance (IR). Although both MS and IR are very common in AGHD, afamin has not been investigated in these patients.PurposeTo investigate afamin as a potential biomarker in patients with AGHD.Materials and methodsParticipants included 20 AGHD patients (11 GH-substituted and 9 GH-unsubstituted) and 37 healthy controls. Subjects underwent routine laboratory examinations, anthropometric measurements, body composition analysis using multi-frequency bioelectrical impedance analysis (InBody720) and measurement of serum afamin concentrations. In GH-substituted subjects, GH-substitution was withdrawn for 2 months. Measurements were carried out right before GH-withdrawal, at the end of the 2-month withdrawal period, and 1 month after reinstituting GH-replacement therapy (GHRT).ResultsGH-unsubstituted patients demonstrated higher afamin levels compared to controls (p=0.03). Afamin positively correlated with skeletal muscle mass, bone mineral content, total body water, extracellular- and intracellular water content, insulin (all, p&lt;0.01), HOMA-IR (p=0.01) and C-peptide (p=0.03) levels in AGHD but not in healthy controls. In GH-substituted patients 2-month of GH-withdrawal caused significant changes in body composition, including decreased fat-free mass, skeletal muscle mass, total body water, and intracellular water content (all, p&lt;0.01); but these changes almost fully recovered 1 month after reinstituting GHRT. Unexpectedly, afamin levels decreased after GH-withdrawal (p=0.03) and increased with reinstitution (p&lt;0.01). Changes of afamin levels during GH-withdrawal positively correlated with changes of HOMA-IR (r=0.80; p&lt;0.01) and changes of insulin (r=0.71; p=0.02).ConclusionHigher afamin levels in unsubstituted AGHD patients might indicate severe metabolic dysregulation. Significant changes accompanying GH-withdrawal and reinstitution, along with strong correlations with measures of IR, suggest that afamin could be a promising biomarker to monitor GHRT-associated changes of insulin sensitivity.
Modeling and simulation of direct contact membrane distillation system integrated with a photovoltaic thermal for electricity and freshwater production
Authors: Maqbool Faisal , Soomro Mujeeb Iqbal , Kumar Laveet , Harijan Khanji 
Published: February 2024

Energy drives the growth, transformation, and economic development of every nation. The vitality of human existence and progress hinges on the accessibility of both energy and water resources. As freshwater resources are diminishing, therefore, desalination needs have increased. In solar membrane distillation systems, the key challenge is maintaining the intake water temperature in the membrane distillation system with fluctuating solar radiation intensity which affects the distillate water quantity and quality. The objective of this study is to enhance and optimize a mathematical model for analyzing a cutting-edge solar-integrated PV/T-DCMD system. In this innovative integration, the direct contact membrane distillation intake water temperature is derived from the photovoltaic thermal output. The integration of direct contact membrane distillation with photovoltaic thermal systems represents a cost-effective and technologically advantageous concept. As the water temperature increases, there is a notable improvement in the evaporation efficiency of PV/T-DCMD systems, with an increase from 35.08% to 42.01%. Additionally, there is a reduction in specific thermal energy consumption, decreasing from 1,192 to 1,386 kWh/m3 as a consequence of the elevated feed water temperature.
Bee-diverse habitats positively affect seed set in wild plant species
Authors: Heuel Kim C. , Ayasse Manfred , Burger Hannah 
Published: February 2024

IntroductionInteractions between flowering plants and visiting wild bees are crucial for ensuring pollination and subsequent plant reproductive success. However, bee diversity in an area has rarely been recorded in relation to seed set in native plants. In this project, we investigated the effect of local wild bee communities on seed set in four common wild plant species.MethodsPotted plants of Centaurea jacea, Cichorium intybus, Sinapis arvensis, and Salvia pratensis were placed for pollination experiments, in two distinct habitat types that we expected to show distinct bee communities, namely near-natural grassland and perennial wild flower strips, in Germany.ResultsOur results showed that near-natural grassland had a higher bee species richness and an increased seed set compared with flower strips that displayed a higher bee abundance in most study locations. Although we found effects of bee diversity on seed set, we did not detect a significant effect of bee abundance. Furthermore, the seed set in response to wild bee diversity differed across the plant species.DiscussionWe conclude that bee-friendly habitats ensure a high seed set in wild plants, but that the impact varies between different plant species.
Genome-wide association and genomic prediction for iron and zinc concentration and iron bioavailability in a collection of yellow dry beans
Authors: Izquierdo Paulo , Sadohara Rie , Wiesinger Jason , Glahn Raymond , Urrea Carlos , Cichy Karen 
Published: February 2024

Dry bean is a nutrient-dense food targeted in biofortification programs to increase seed iron and zinc levels. The underlying assumption of breeding for higher mineral content is that enhanced iron and zinc levels will deliver health benefits to the consumers of these biofortified foods. This study characterized a diversity panel of 275 genotypes comprising the Yellow Bean Collection (YBC) for seed Fe and Zn concentration, Fe bioavailability (FeBio), and seed yield across 2 years in two field locations. The genetic architecture of each trait was elucidated via genome-wide association studies (GWAS) and the efficacy of genomic prediction (GP) was assessed. Moreover, 82 yellow breeding lines were evaluated for seed Fe and Zn concentrations as well as seed yield, serving as a prediction set for GP models. Large phenotypic variability was identified in all traits evaluated, and variations of up to 2.8 and 13.7-fold were observed for Fe concentration and FeBio, respectively. Prediction accuracies in the YBC ranged from a low of 0.12 for Fe concentration, to a high of 0.72 for FeBio, and an accuracy improvement of 0.03 was observed when a QTN, identified through GWAS, was used as a fixed effect for FeBio. This study provides evidence of the lack of correlation between FeBio estimated in vitro and Fe concentration and highlights the potential of GP in accurately predicting FeBio in yellow beans, offering a cost-effective alternative to the traditional assessment of using Caco2 cell methodologies.
Altered spontaneous brain activity in lumbar disc herniation patients: insights from an ALE meta-analysis of neuroimaging data
Authors: Qiu Zhiqiang , Zhong Xiangkai , Yang Qiming , Shi Xiran , He Libing , Zhou Huiling , Xu Xiaoxue 
Published: February 2024

ObjectiveTo explore the characteristics of spontaneous brain activity changes in patients with lumbar disc herniation (LDH), and help reconcile the contradictory findings in the literature and enhance the understanding of LDH-related pain.Materials and methodsPubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), SinoMed, and Wanfang databases were searched for literature that studies the changes of brain basal activity in patients with LDH using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation/fraction amplitude of low-frequency fluctuation (ALFF/fALFF) analysis methods. Activation likelihood estimation (ALE) was used to perform a meta-analysis of the brain regions with spontaneous brain activity changes in LDH patients compared with healthy controls (HCs).ResultsA total of 11 studies were included, including 7ALFF, 2fALFF, and 2ReHo studies, with a total of 269 LDH patients and 277 HCs. Combined with the data from the ALFF/fALFF and ReHo studies, the meta-analysis results showed that compared with HCs, LDH patients had increased spontaneous brain activity in the right middle frontal gyrus (MFG), left anterior cingulate cortex (ACC) and the right anterior lobe of the cerebellum, while they had decreased spontaneous brain activity in the left superior frontal gyrus (SFG). Meta-analysis using ALFF/fALFF data alone showed that compared with HCs, LDH patients had increased spontaneous brain activity in the right MFG and left ACC, but no decrease in spontaneous brain activity was found.ConclusionIn this paper, through the ALE Meta-analysis method, based on the data of reported rs-fMRI whole brain studies, we found that LDH patients had spontaneous brain activity changes in the right middle frontal gyrus, left anterior cingulate gyrus, right anterior cerebellar lobe and left superior frontal gyrus. However, it is still difficult to assess whether these results are specific and unique to patients with LDH. Further neuroimaging studies are needed to compare the effects of LDH and other chronic pain diseases on the spontaneous brain activity of patients. Furthermore, the lateralization results presented in our study also require further LDH-related pain side-specific grouping study to clarify this causation.Systematic review registrationPROSPERO, identifier CRD42022375513.
Interpretable machine learning model to predict surgical difficulty in laparoscopic resection for rectal cancer
Authors: Yu Miao , Yuan Zihan , Li Ruijie , Shi Bo , Wan Daiwei , Dong Xiaoqiang 
Published: February 2024

BackgroundLaparoscopic total mesorectal excision (LaTME) is standard surgical methods for rectal cancer, and LaTME operation is a challenging procedure. This study is intended to use machine learning to develop and validate prediction models for surgical difficulty of LaTME in patients with rectal cancer and compare these models’ performance.MethodsWe retrospectively collected the preoperative clinical and MRI pelvimetry parameter of rectal cancer patients who underwent laparoscopic total mesorectal resection from 2017 to 2022. The difficulty of LaTME was defined according to the scoring criteria reported by Escal. Patients were randomly divided into training group (80%) and test group (20%). We selected independent influencing features using the least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression method. Adopt synthetic minority oversampling technique (SMOTE) to alleviate the class imbalance problem. Six machine learning model were developed: light gradient boosting machine (LGBM); categorical boosting (CatBoost); extreme gradient boost (XGBoost), logistic regression (LR); random forests (RF); multilayer perceptron (MLP). The area under receiver operating characteristic curve (AUROC), accuracy, sensitivity, specificity and F1 score were used to evaluate the performance of the model. The Shapley Additive Explanations (SHAP) analysis provided interpretation for the best machine learning model. Further decision curve analysis (DCA) was used to evaluate the clinical manifestations of the model.ResultsA total of 626 patients were included. LASSO regression analysis shows that tumor height, prognostic nutrition index (PNI), pelvic inlet, pelvic outlet, sacrococcygeal distance, mesorectal fat area and angle 5 (the angle between the apex of the sacral angle and the lower edge of the pubic bone) are the predictor variables of the machine learning model. In addition, the correlation heatmap shows that there is no significant correlation between these seven variables. When predicting the difficulty of LaTME surgery, the XGBoost model performed best among the six machine learning models (AUROC=0.855). Based on the decision curve analysis (DCA) results, the XGBoost model is also superior, and feature importance analysis shows that tumor height is the most important variable among the seven factors.ConclusionsThis study developed an XGBoost model to predict the difficulty of LaTME surgery. This model can help clinicians quickly and accurately predict the difficulty of surgery and adopt individualized surgical methods.
SelfCare when working from home: easier but also more important
Authors: Krick Annika , Arnold Miriam , Felfe Jörg 
Published: February 2024

IntroductionTelework brings opportunities (e.g., flexibility) but also potential risks for health (e.g., fewer boundaries, constant availability). SelfCare could be a relevant work-related resource to reduce these health risks when working from home. SelfCare is part of the Health-oriented Leadership model and describes how individuals prioritize their own health, are aware of signs of stress, and actively promote their own health. In this paper, we postulate that telework enables more SelfCare at home, e.g., due to higher flexibility and autonomy. As SelfCare at home can be used more flexibly, it is also conceivable that the effectiveness of SelfCare increases the more employees work from home. Additionally, for hybrid working employees, the question arises whether SelfCare at both work contexts is distinct and makes an independent contribution to health and whether they even reinforce each other.MethodsOur hypotheses were tested in a longitudinal study withN= 727 employees from different industries. This study examined (1) the level of SelfCare on-site and at home (within- and between-person-effects), (2) the moderating effect of telework intensity on the effectiveness of SelfCare at home on health and performance indicators, and (3) direct and interacting effects of SelfCare at home and on-site for health.ResultsBetween- and within-person-differences show that SelfCare is more prevalent when working from home. Furthermore, SelfCare at home is related to less strain and health complaints as well as more relaxation and performance for individuals with higher telework intensity. SelfCare at home and on-site independently predict strain and health complaints and interact with regard to strain.DiscussionSelfCare appears to be more relevant with higher telework intensity and is thus an even more important health resource in the telework context. Organizations should provide continuing interventions and online tools to promote SelfCare among employees and leaders. Since little is known about the level and the effects of SelfCare in the telework context, these findings expand previous research on Health-oriented Leadership in the telework context.
Parent-perceived recurrent pain in children: associations with maternal pain, depressiveness, socioeconomic status, and children's behavioural difficulties
Authors: Petri Laura , Poulain Tanja , Vogel Mandy , Meigen Christof , Kiess Wieland , Hiemisch Andreas 
Published: February 2024

ObjectivesThe current study aimed to examine the potential transgenerational associations between maternal pain and depressiveness and childhood pain, and to explore the associations between the children's difficulties and recurrent pain (defined as pain occurring at least once a month in the previous 6 month) in healthy children aged 3–13 years.MethodsWe collected Data between 2015 and 2019 as part of the LIFE Child study in Germany and investigated associations of maternal pain and depressiveness, child age, sex, pubertal stage, emotional difficulties, conduct difficulties, hyperactivity/inattention, peer group difficulties, and prosocial skills, and family socioeconomic status with the frequency of parent-perceived headache, backache, and stomachache in a sample of 1,850 children (4,819 documented visits) using logistic and ordinal regression analyses.ResultsOverall, 10.4%, 24.4%, and 45.2% of parents reported their children had recurrent backache, headache, and stomachache, respectively, with 5.5% of children were reported to experience all three types of pain simultaneously. Higher age, female sex, puberty, emotional difficulties, low family socioeconomic status, as well as higher maternal impairment due to pain and maternal depressiveness were significantly associated with more frequent pain.ConclusionsOur study suggests that maternal pain, maternal depressiveness, and lower family socioeconomic status as well as child's emotional difficulties are significantly associated with a higher frequency of recurrent pain in children perceived by their parents.
Airway opening pressure maneuver to detect airway closure in mechanically ventilated pediatric patients
Authors: Rodriguez Guerineau Luciana , Vieira Fernando , Rodrigues Antenor , Reise Katherine , Todd Mark , Guerguerian Anne-Marie , Brochard Laurent 
Published: February 2024

BackgroundAirway closure, which refers to the complete collapse of the airway, has been described under mechanical ventilation during anesthesia and more recently in adult patients with acute respiratory distress syndrome (ARDS). A ventilator maneuver can be used to identify airway closure and measure the pressure required for the airway to reopen, known as the airway opening pressure (AOP). Without that maneuver, AOP is unknown to clinicians.ObjectiveThis study aims to demonstrate the technical adaptation of the adult maneuver for children and illustrate its application in two cases of pediatric ARDS (p-ARDS).MethodsA bench study was performed to adapt the maneuver for 3–50 kg patients. Four maneuvers were performed for each simulated patient, with 1, 2, 3, and 4 s of insufflation time to deliver a tidal volume (Vt) of 6 ml/kg by a continuous flow.ResultsAirway closure was simulated, and AOP was visible at 15 cmH2O with a clear inflection point, except for the 3 kg simulated patient. Regarding insufflation time, a 4 s maneuver exhibited a better performance in 30 and 50 kg simulated patients since shorter insufflation times had excessive flowrates (&gt;10 L/min). Below 20 kg, the difference in resistive pressure between a 3 s and a 4 sec maneuver was negligible; therefore, prolonging the maneuver beyond 3 s was not useful. Airway closure was identified in two p-ARDS patients, with the pediatric maneuver being employed in the 28 kg patient.ConclusionsWe propose a pediatric AOP maneuver delivering 6 ml/kg of Vt at a continuous low-flow inflation for 3 s for patients weighing up to 20 kg and for 4 s for patients weighing beyond 20 kg.
Attitudes and health behaviors of middle-aged and older adults with elevated tumor markers in China
Authors: Yu Renke , Xu Zhijie , Lu Yiting , Zhu Yue , Chen Liying 
Published: February 2024

ObjectivesTo understand the attitudes and health behaviors of middle-aged and older adults in China after receiving elevated results of tumor markers (TMs) test in the annual health examinations (AHEs) and explore the influencing factors.MethodsA three-section online questionnaire survey was conducted from March 1 to April 30, 2020 in Hangzhou, China, to people who were aged 45 and older and had at least one elevated result of TMs test. Clinical information was collected from the online survey and medical records. Descriptive statistics were carried out followed by regression analyses.ResultsOf 380 participants, 76.1% were unwilling to quit the TMs test in AHEs, whereas 75.3% would take the doctor’s advice and quit unnecessary TMs test; 67.4% felt stressed about their TMs. Among participants with elevated TMs, 76.8% changed lifestyle to keep healthy, 74.2% sought health information, 58.9% requested a TMs retest, and 50.3% did further tests to confirm a diagnosis. Family history of cancer was associated with lifestyle changing; education level, area of residence and health insurance were associated with health information seeking; comorbidity were associated with retests and sequential confirming tests.ConclusionThe application of the TMs test in AHEs among Chinese people may lead to positive and negative behavioral consequences and psychological distress. Doctors have a significant impact on patients’ health behaviors. Accurate indications and adequate communication with patients before and after the TMs test are in great need.
People who living with HIV/AIDS also have a high prevalence of anxiety disorders: a systematic review and meta-analysis
Authors: Ji Jiahao , Zhang Yang , Ma Yundong , Jia Lin , Cai Miaotian , Li Zhen , Zhang Tong , Guo Caiping 
Published: February 2024

BackgroundAn estimated 301 million people worldwide suffer from anxiety disorders. People living with HIV/AIDS (PLWHA) are particularly prone to anxiety disorders that could interfere with the important developmental process in an individual’s development and ultimately result in a wide range of negative mental, physical, and psychosocial consequences, as well as poor quality of life in those population groups. Early intervention for anxiety disorders can reverse some of the physical damage caused by anxiety. However, based on systematic reviews and meta-analyses, the specific prevalence of anxiety disorders in PLWHA remains unknown.MethodWe conducted a literature search on PubMed, Embase, and Web of Science up to 22 October 2022. A random-effects meta-analysis was used to pool prevalence rates from the included studies. Sensitivity and subgroup analyses were performed to identify the possible sources of heterogeneity and to compare the prevalence estimates across groups. The Joanna Briggs Institute’s Quality Assessment Checklist was used to assess the quality of the included studies. Cochran’s Q and I2 tests were used to assess the between-study heterogeneity.ResultsTen studies with a total of 238,570 cases were included for the final analysis. Results showed that 15.5% of HIV/AIDS patients had anxiety disorders. The prevalence was higher in females (20.8%) than males (20.7%). The mean age of PLWHA with anxiety disorders was 46.58 ± 11.15 years in these included studies. The subgroup analyses showed significant higher prevalence in non-heterosexual (32.1%).ConclusionWe attempted to quantify literature that could allow for stronger inferences to be made regarding the significantly higher prevalence of anxiety disorders in PLWHA, a finding that suggests the imperativeness of intervention strategies to alleviate suffering and reduce the probable negative ramifications.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023442219, identifier CRD42023442219.