bluuebunny/crossref_metadata_2025_split huggingface dataset:
Airport Time Profile Construction Driven by Flight Delay Prediction
Authors: GAO Wei , Pang Dingying 
Published: February 2024

Abstract

The time structure is the equilibrium outcome resulting from the interaction between market demand and the availability of time resources, with time parameters reflecting the operational support capability of the aviation system.The construction of time parameters and time structure should not only reflect changes in market demand, but also meet the constraints of operational efficiency.Constructing a reasonable 18–24 hour timetable profile for busy airports that meets normal expectations for declared capacity and seasonal scheduling is a challenge in civil aviation slot management.This study utilizes historical data on airport flights and weather conditions to establish a regression prediction model for the time structure using K-means clustering and Partial Least Squares Regression. Additionally, Ensemble learning is employed to forecast flight delay levels. The findings demonstrate that Random Forest yields favorable results in regression and prediction tasks, allowing for the integration of upper(good weather) and lower(severse weather) limits of the time profile with delay predictions as time parameter intervals. Consequently, the flights falling within these intervals achieve an average delay level of less than 15 minutes.That is, it meets the expectations of flight normality.
Application of the fractional-order theory of micro-polar thermoelasticity in the solid cylinder
Authors: Khader Shaaban , Marrouf Ayman , Khedr Mona 
Published: February 2024

Abstract

This work examines the heat transfer efficiency of CuZnFe2O4-water and NiZnFe4O4-water magnetic nanofluids when subjected to forced convection with an external magnetic field. The experiments were carried out utilizing nanofluids that were generated with volume concentrations of 0.5% and 1.0% in a mini-channel. The studies were conducted with consistent heat flux boundary conditions within the Reynolds number range of 300–1300. A magnetic field within the 22–38 mT range has been produced by using two electromagnets positioned at a right angle to the direction of flow. The collected data has shown substantial improvements in the Nusselt number when using nanofluids. Applying an external magnetic field to nanofluids led to substantial improvements in heat transfer. The influence of the magnetic field on the transport of heat was particularly noticeable in situations characterized by low Reynolds numbers and nanofluids containing a high concentration of nanoparticles. Furthermore, it was noted that the magnitude of the magnetic field also has a substantial favorable impact. The highest rates of increase in the Nusselt number were attained for both nanofluids when the volume concentration was 1.0%, the Reynolds number was 300, and the magnetic field intensity was set at 38 mT. In addition, the CuZnFe2O4-water nanofluid exhibited a greater susceptibility to the magnetic field in comparison to the NiZnFe4O4-water nanofluid. Relative to the scenario without a magnetic field, the NiZnFe4O4-water nanofluid exhibited a maximum Nusselt number increase rate of 24.62%, while the CuZnFe2O4-water nanofluid demonstrated a higher increase rate of 39.34%.
Long-Term Memory Plasticity: A Decade-Long Connectivity Study Post Anterior Temporal Lobe Resection
Authors: Fleury Marine , Binding Lawrence , Taylor Peter , Xiao Fenglai , Giampiccolo Davide , Buck Sarah , Winston Gavin , Thompson Pamela , Baxendale Sallie , Koepp Matthias , Duncan John , Sidhu Meneka 
Published: February 2024

Abstract

Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. Despite the importance of early memory network changes, long-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery. From 3–12 months to 10 years postoperatively, we assessed memory network changes in 25 patients (12 left-sided resections) relative to 10 healthy matched controls, using longitudinal, task-based functional MRI and standard neuropsychology assessments. In a predominantly seizure-free cohort, our findings highlight the potential for sustained cognitive improvement and reduced medication needs over a decade after epilepsy surgery. We observed specific changes in memory networks and identified regions crucial for long-term verbal and visual memory recovery. These findings endorse strategic approaches in epilepsy treatment: advocating for conservative surgeries and promoting the long-term use of cognitive rehabilitation for ongoing recovery.
Predicting Malignancy in Breast Lesions: Enhancing Accuracy with Fine-Tuned Convolutional Neural Network Models
Authors: Li Li , Pan Changjie , Zhang Ming , Shen Dong , He Guangyuan , Meng Mingzhu 
Published: February 2024

Abstract

Objectives.
This study aimed to explore which convolutional neural network (CNN) model is best for predicting the likelihood of malignancy on dynamic contrast-enhanced breast magnetic resonance imaging (DCE-BMRI).
Materials and Methods.
A total of 273 benign (benign group) and 274 malignant lesions (malignant group) were obtained, and randomly divided into a training set (benign group: 246 lesions, malignant group: 245 lesions) and a testing set (benign group: 28 lesions, malignant group: 28 lesions) in a 9:1 ratio. An additional 53 lesions from 53 patients were designated as the validation set. Five models (VGG16, VGG19, DenseNet201, ResNet50, and MobileNetV2) were evaluated. The metrics for model performance evaluation included accuracy (Ac) in the training and testing sets, and precision (Pr), recall rate (Rc), F1 score (F1), and area under the receiver operating characteristic curve (AUC) in the validation set.
Results.
Accuracies of 1.0 were achieved on the training set by all five fine-tuned models (S1-5), with model S4 demonstrating the highest test accuracy at 0.97. Additionally, S4 showed the lowest loss value in the testing set. The S4 model also attained the highest AUC (Area Under the Curve) of 0.89 in the validation set, marking a 13% improvement over the VGG19 model. Notably, the AUC of S4 for BI-RADS 3 was 0.90 and for BI-RADS 4 was 0.86, both significantly higher than the 0.65 AUC for BI-RADS 5.
Conclusion.
The S4 model we propose emerged as the superior model for predicting the likelihood of malignancy in DCE-BMRI and holds potential for clinical application in patients with breast diseases. However, further validation is necessary, underscoring the need for additional data.
Changes in the Nutritional Value of Timothy (Phleum pratense L.) Biomass as a Response to Varied Organomineral Treatment
Authors: Wiśniewska-Kadżajan Beata , Malinowska Elżbieta 
Published: February 2024

Abstract

The aim of the experiment was to determine the impact of the interaction of slurry with soil conditioners used in organic farming on selected feed parameters of Phleum pratense biomass.
The research was conducted in three replications at the experimental facility of Siedlce University (52°10′03"N; 22°17′24"E, Poland) in years 2015 - 2017. The fertilizers used in the experiment were cattle slurry used separately and supplemented with leonardite extract and vermicompost extract, as well as mineral NPK. Cattle slurry was used each year at a total dose of 30 m3 ha-1, divided into individual cuts. Soil conditioners were used in accordance with the manufacturer's recommendations. NPK mineral fertilization was applied at doses: N – 100, P – 30, K – 100 kg ha-1. The tested plant in the experiment was forage grass of the species Phleum pratense of the Secesja variety. The content of the neutral detergent fiber fraction and acid detergent fiber fraction was analyzed in the plant material samples using near-infrared reflectance spectroscopy (NIRS). The relative nutritional value was determined based on the neutral and acid detergent fiber fraction content. It was shown that the addition of vermicompost and NPK extract to the slurry improved the values of the tested parameters compared to the slurry alone. The feed value of biomass collected from facilities fed with slurry and NPK was higher than the feed value of biomass fertilized with slurry with leonardite extract, but comparable to the value of biomass fertilized with slurry supplemented with vermicompost extract.
Impact of haemogregarine parasite infections on the behaviour of Podarcis lizards
Authors: Faria J. Filipe , Harris D. James 
Published: February 2024

Abstract

Modern studies have shown how parasites add extra complexity to species interactions with their ecosystems by the way they affect their host. Haemogregarine parasites are common in lizards, although various studies have suggested varying degrees of repercussions for the host. In this study, we investigate effects of haemogregarine infection on the boldness and aggressiveness of male lizards of two sympatric species living in North Portugal: Podarcis bocagei and Podarcis lusitanicus, known hosts of haemogregarine and coccidian parasites. We used mirror interaction tests to assess aggressiveness, which did not identify any influence of the infection on either species. Boldness was evaluated through exploratory tests, with our results suggesting P. lusitanicus parasitized with Hepatozoon sp. alter their behaviour, with an increase in their exploratory activity and willingness to expose themselves for longer periods. Infection with Hepatozoon sp. appears to be enough to cause this abrupt behavioural change, independently of intensity of infection. These changes were only identified in P. lusitanicus, with P. bocagei maintaining their behaviour independently of infection status. Our results suggest a link between the observed behavioural changes for P. lusitanicus and thermoregulation, although further experiments to clarify this hypothesis are required.
Identification of Shared Gene Signatures and Pathways for Diagnosing Osteoporosis with Sarcopenia through Integrated Bioinformatics Analysis and Machine Learning
Authors: Zhou Xiaoli , Chen Guangdong , Chen Yang , Zhang Zepei , Miao Jun 
Published: February 2024

Abstract
Background
Prior studies have suggested a potential relationship between osteoporosis and sarcopenia, both of which can present symptoms of compromised mobility. Additionally, fractures among the elderly are often considered a common outcome of both conditions. There is a strong correlation between fractures in the elderly population, decreased muscle mass, weakened muscle strength, heightened risk of falls, and diminished bone density. This study aimed to pinpoint crucial diagnostic candidate genes for osteoporosis patients with concomitant sarcopenia.
Methods
Two osteoporosis datasets and one sarcopenia dataset were obtained from the Gene Expression Omnibus (GEO). Differential expression genes (DEGs) and module genes were identified using Limma and Weighted Gene Co-expression Network Analysis (WGCNA), followed by functional enrichment analysis, construction of protein-protein interaction (PPI) networks, and application of a machine learning algorithm (least absolute shrinkage and selection operator (LASSO)regression) to determine candidate hub genes for diagnosing osteoporosis combined with sarcopenia. Receiver operating characteristic (ROC) curves and column line plots were generated.
Results
The merged osteoporosis dataset comprised 2067 DEGs, with 424 module genes filtered in sarcopenia. The intersection of DEGs between osteoporosis and sarcopenia module genes consisted of 60 genes, primarily enriched in viral infection. Through construction of the PPI network, 30 node genes were filtered, and after machine learning, 7 candidate hub genes were selected for column line plot construction and diagnostic value assessment. Both the column line plots and all 7 candidate hub genes exhibited high diagnostic value (area under the curve ranging from 1.00 to 0.93).
Conclusion
We identified 7 candidate hub genes (PDP1, ALS2CL, VLDLR, PLEKHA6, PPP1CB, MOSPD2, METTL9) and constructed column line plots for osteoporosis combined with sarcopenia. This study provides reference for potential peripheral blood diagnostic candidate genes for sarcopenia in osteoporosis patients.
Experts’ views on the implementation of digital interventions for eating disorders: A Delphi study
Authors: Lemmer Diana , Mayer Gwendolyn , Schrader Pauline , Michelsen Ina , Friederich Hans-Christoph , Bauer Stephanie 
Published: February 2024

Abstract

Background Eating disorders (EDs) constitute a considerable burden for individuals and society, but adequate and timely professional treatment is rare. Evidence-based Digital Mental Health Interventions (DMHIs) have the potential both to reduce this treatment gap and to increase treatment effectiveness. However, their integration into routine care is lacking. Understanding practitioners' attitudes towards DMHIs for EDs is crucial for their effective use.Aims To investigate the consensus among German ED treatment experts on the relevance of different influencing factors for DMHI use in EDs.Methods Semi-structured qualitative telephone interviews with N = 24 ED experts (Mage=41.96, SDage=9.92, n = 22 female) were conducted to explore attitudes, experiences, and expectations towards DMHIs. Ten interviews were used for this Delphi study. Content analysis identified 63 influencing factors, grouped into three main categories: contextual conditions, design, and content of DMHIs. In two rounds, participants rated the factors’ importance on 10-point scales. Group percentages and individual ratings of the first round (n = 23) were presented in the second round (n = 21). Consensus was calculated for each item (defined as IQR ≤ 2).Results Importance ratings were high across items (M = 7.88, SD = 2.07, Mdn = 8). In the first round, a consensus rate of 48% was reached, with its most important (Mdn = 10) factors referring to data security, evidence base, technical requirements, usability, and to specific DMHI content (psychoeducation, crisis intervention). In the second Delphi round, consensus was reached for 73% of the items. No consensus was reached for 17 items.Conclusions The findings on practitioners' attitudes and priorities have relevant implications for subsequent DMHI development, dissemination, and implementation strategies, indicating that the highest-rated factors should be highlighted in the process.
Enasidenib causes clinically relevant rosuvastatin accumulation leading to toxic myopathy
Authors: Mason George , Cashion Catelyn , Parratt Jonathon , Stevenson William 
Published: February 2024

Abstract
A woman in her 80s developed AML while on rosuvastatin secondary prevention. IDH2 mutation was identified and Enasidenib was commenced as second line therapy and later presented with clinical, biochemical and radiographic evidence of myositis, without an alternative cause. We report the first case of enasidenib induced statin toxic myopathy, and discuss implications for AML patients most likely to receive this therapy.
Management of open craniocerebral injury in a patient with a skull defect: a case report
Authors: Qi Haihui , Song Mengruo , Xu Ya , Chen Zhenglou , Gui Qunfeng 
Published: February 2024

Abstract

Background: Open craniocerebral injury is a bodily injury that is characterized by high mortality and poor prognosis. This type of trauma occurs in patients with skull defects; this is a peculiar accident and is relatively rare. Because of its rarity, the treatments for such injuries are complex and nonstandardized.
Case presentation: We present the case of a 66-year-old male with a right frontotemporal skull defect who was hit by a tractor in his head and was accompanied by loss of consciousness for 3 h. Computer tomography (CT) demonstrated a hit on the left frontal area and a multifragmented fracture of the bilateral frontal and orbital bone with partial defects and partial elevation of the fractured bone fragments. A hemorrhagic contusion in the bilateral frontal area directly next to the injury was accompanied by a subdural hematoma at the skull defect site, subarachnoid hemorrhage, or ventricular hemorrhage. Early debridement, hematoma evacuation, and decompressive craniectomy were performed, and the patient achieved good postoperative recovery.
Conclusions: In this study, we discussed the clinical presentation and successful management of this unique injury in a patient with a skull defect. Our goal is to demonstrate certain general management principles that can improve patient outcomes.
Heat transfer enhancement on the rectangle microchannel heat sink
Authors: Li Qing-wen , Shang Xue-shuo , Cao Qun , Cui Zheng , Shao Wei 
Published: February 2024

Abstract
Microchannel heat sink is widely used in the aera of heat dissipation of electric device. This paper establishes a numerical model of rectangle microchannel heat sink and an experimental platform for validation. To enhance the thermal performance, the models of interrupted and staggered-interrupted channels are simulated. By comparing the Performance Evaluation Criterion (PEC) the results indicates that the performance of interrupted microchannels increases by approximately 10% to the continuous microchannels, while the staggered microchannels showed the best performance of up to 23% enhancement. Additionally, temperature uniformity increases by about 14% at Reynolds numbers below 150.
Whole genome-based surveillance for human adenovirus-related diseases in Kobe City, Japan, 2018–2022
Authors: Tanimoto Yoshihiko , Ohyama Minori , Ito Erika , Akiyoshi Kyoko , Onishi Yuka , Mori Ai , Nomoto Ryohei 
Published: February 2024

Abstract
Background: Human adenoviruses (HAdVs) cause various diseases, and they frequently undergo recombination. As adenoviruses are susceptible to recombination, whole-genome sequencing and analysis are essential approaches to understanding viral properties. In the present study, we performed whole-genome sequencing to characterize adenoviruses and assess the prevalence of adenovirus-related diseases in Kobe, Japan.
Methods: Eighty HAdV cell culture-positive strains isolated from clinical specimens in Kobe City, Japan, between 2018 and 2022 were used. Whole-genome sequencing, phylogenetic analyses, and recombination analyses were performed.
Results: Disease-specific HAdV species were detected, with species B and C being the primary species detected for pharyngoconjunctival feverand species F for infectious gastroenteritis. All species B strains belonged to the HAdV-3 genotype. Multiple genotypes were detected in species C, including five strains in which the new genotype, P85H5F5, was identified in PCF specimens.
Conclusions: Whole-genome analysis of HAdV is an important approach not only for understanding local epidemics, but also for monitoring the emergence of recombinant genotypes.
Aberrant left coronary artery from the pulmonary artery with patent ductus arteriosus - A case report and review of the literature
Authors: Amer Ahmad , Shai Hanita , Assa Sagi , Mitler Avital , Sternfeld Alona Raucher 
Published: February 2024

Abstract
Background: Aberrant left coronary artery from pulmonary artery (ALCAPA) is a very rare congenital heart defect. Its coexistence with patent ductus arteriosus (PDA) is extremely rare. The high pressures created by the left-to-right shunt in the pulmonary arteries can delay symptoms and create a real challenge in diagnosing ALCAPA. Missing this diagnosis can have severe results, including extensive ischemia and sudden death.
Case presentation: We present a case of an infant born with a large PDA. Initially treated conservatively; however, due to congestive heart failure and lack of weight gain, she underwent surgical ligation of the PDA at the age of four and a half months. Following surgery, she developed pulmonary edema. Echocardiography revealed decreased ventricular function. ECG revealed ST elevations on lateral leads, and serum troponin was significantly increased. The patient underwent cardiac magnetic resonance imaging (MRI), which revealed signs of wall ischemia and decreased function of the left ventricle (LV) with unclear coronary anatomy. Diagnostic catheterization revealed an ALCAPA. She underwent surgical intervention, and the left coronary artery was re-implanted in the aortic sinus. Follow-up revealed slow improvement of cardiac function.
Discussion and literature review: The coexistence of PDA and ALCAPA is a very rare occurrence. We found at least 10 reported cases in the literature. Delayed diagnosis might be detrimental. The prognosis of these patients is variable.
Conclusion: An unusual post-surgical course following PDA repair requires a high index of suspicion and appropriate evaluation for ALCAPA, preferably with angiography.
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
Authors: Raninga Prahlad , Zeng Bijun , Moi Davide , Saletta Federica , Venkat Pooja , Mayoh Chelsea , D'Souza Rochelle , Day Bryan , Shai-Hee Tyler , Vittorio Orazio , Mazzieri Roberta , Dolcetti Riccardo , Khanna Kum Kum 
Published: February 2024

Abstract

The MYC proto-oncogene is upregulated in > 60% of triple-negative breast cancers (TNBCs), it can directly promote tumor cell proliferation and its overexpression negatively regulates anti-tumor immune responses. For all these reasons, MYC has long been considered as a compelling therapeutic target. However, pharmacological inhibition of MYC function has proven difficult due to a lack of a drug-binding pocket. Here, we demonstrate that the potent abrogation of MYC gene transcription by CBL0137 induces immunogenic cell death and reduces proliferation in MYC-high but not in MYC-low TNBC in vitro. CBL0137 also significantly inhibited the in vivo growth of primary tumors in a human MYC-high TNBC xenograft model (MDA-MB-231). Moreover, CBL0137 inhibited the tumor growth of highly aggressive mouse 4T1.2 syngeneic TNBC model in immunocompetent mice by inhibiting the MYC pathway and inducing Type I interferon responses. Immune profiling of CBL0137-treated mice revealed significantly enhanced tumor-specific immune responses and increased proportions of tumor infiltrating effector CD8+ T cells, CD4+ T cells, and NK cells. CBL0137-induced immune activation also resulted in increased exhaustion of immune effector cells. In particular, NKG2A up-regulation on activated effector cells and of its ligand Qa-1b on tumors in vivo was identified as a possible immune evasive mechanism. Indeed, NKG2A blockade synergized with CBL0137 significantly inhibiting the in vivo growth of 4T1.2 tumors. Collectively, our findings provide the rationale supporting the exploitation of CBL0137-induced anti-tumor immunity in combination with NKG2A blockade to improve the treatment of TNBC expressing high levels of MYC.