bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modular DNA origami compartments for the engineering of a protein unfolding and degradation pathway
Authors: Saccà Barbara , Huang Jing , Jaekel Andreas , Boom Johannes van den , Podlesainski David , Elnagar Manar , Heuer-Jungemann Amelie , Kaiser Markus , Meyer Hemmo 
Published: September 2023

Abstract

Within the cell, chemical reactions are often confined and organized through a modular architecture. This facilitates the targeted localization of molecular species and their efficient translocation to subsequent sites. Here, we present a cell-free nanoscale model that exploits this compartmentalization principle to carry out regulated protein unfolding and degradation. Our model is composed of two connected DNA origami nanocompartments, one containing the protein unfolding machine, p97, and the other housing the protease chymotrypsin. We achieve the unidirectional immobilization of p97, establishing a ‘gateway’ mechanism that controls compartment accessibility and directionality of substrate processing. Our data show that, whereas spatial confinement increases the reaction rate of each individual enzyme, their physical connection into a chimera further improves their performance, minimizing off-target proteolysis. We anticipate that our modular approach may serve as a blueprint for reshaping biocatalytic pathways and stimulating the creation of nanofactories with capabilities beyond those observed in natural systems.
Rapid proton diffusion in heavily Sc-doped soft perovskite oxides
Authors: Tsujikawa Kota , Hyodo Junji , Fujii Susumu , Takahashi Kazuki , Kasamatsu Shusuke , Yamazaki Yoshihiro 
Published: September 2023

Abstract

Advances in electrochemical devices have been primarily driven by the discovery and development of electrolyte materials. However, finding an electrolyte that exhibits both high ionic conductivity and chemical and electrochemical stability remains a significant challenge. Here, we developed such an electrolyte with heavily Sc-doped BaSn0.3Sc0.7O3H0.66. The resulting proton conductivities in BaSn0.3Sc0.7O3H0.66 and BaTi0.2Sc0.8O3H0.74 exceed 0.01 Scm−1 at 300°C. The former maintains chemical stability for over 360 h under 0.98 atm of humidified CO2 and electrochemical stability for over 100 h during fuel cell operation, with a theoretical overpotential of 1.194 V and proton conductivity of 0.01 Scm−1 at 300°C. Heavy Sc doping into perovskites reduces the activation energy for proton diffusion, probably due to reduced proton trapping. Screening for softer oxides with maximum Sc solubility is a promising strategy for developing fast and stable proton-conducting electrolytes capable of operating at 300°C.
Contrasting patterns of DNA damage in rural workers from central Brazil: what may account for the geographical variation in genotoxicity following occupational exposure to pesticides?
Authors: Nascimento Felipe de Araújo , Ramos Jheneffer Sonara Aguiar , Pedroso Thays Millena Alves , Godoy Fernanda Ribeiro , Souza Murilo Mendonça Oliveira , Parise Michelle Rocha , Silva Daniela Melo 
Published: September 2023

Abstract
In recent years, the use of pesticides has intensified worldwide, and many countries have tended to neglect the potential toxic effects associated with the indiscriminate use of these substances. Many diseases, such as Hodgkin’s lymphoma, lung and prostate cancer, and autoimmune disorders, have been linked to the use of pesticides. The present study compared the DNA damage observed in rural workers from five different areas of the central Brazilian state of Goiás. We attempted to identify the factors that influence the patterns of genotoxicity found in 367 rural workers from the municipalities of Goiânia, Rio Verde, Montividiu, Jatai, and Silvânia. The DNA damage was assessed using comet assays, and the results were compared with the data on epidemiological variables, behavioral parameters, and the types of pesticide used. Significant variation was found in the level of DNA damage in rural workers from different municipalities, although no clear differences were observed in demographic or behavioral parameters. All the different classes of pesticides were related to similar levels of DNA damage, which indicates that other factors may be influencing the differences observed among the populations. A positive correlation was found between the level of DNA damage and the number of pesticides used per individual, which suggests potential synergistic effects of pesticide mixtures, which may enhance the risk of DNA damage. Rural workers from Goiânia and Silvania presented the highest levels of DNA damage. In addition to the quantity of pesticides and the synergistic effects of mixtures, the results of the present study would appear to point to genetic polymorphisms in detoxification genes (e.g., OGG1 and XRCC), which may determine variation in the general susceptibility of the different populations to DNA damage. This emphasizes the need for further research on the possible variation in genetic factors in the different groups of rural workers.
New determination of the production cross section for secondary positrons and electrons in the Galaxy
Authors: Orusa Luca , Di Mauro Mattia , Donato Fiorenza , Korsmeier Michael 
Published: September 2023

The cosmic-ray fluxes of electrons and positrons (e^{&#177;}e±) are measured with high precision by the space-borne particle spectrometer AMS-02. To infer a precise interpretation of the production processes for e^{&#177;}e± in our Galaxy, it is necessary to have an accurate description of the secondary component, produced by the interaction of cosmic-ray proton and helium with the interstellar medium atoms. We determine new analytical functions of the Lorentz invariant cross section for the production of e^&#177;e± by fitting data from collider experiments. The total differential cross section d\sigma/dT_{e^&#177;}(p+p&#8594; e^&#177;+X)dσ/dTe±(p+p→e±+X) is predicted with an uncertainty of about 5-7% in the energies relevant for AMS-02 positron flux. For further information about this work refer to [Phys. Rev. D 105, 123021 (2022)].
Intermedialidad, imaginación creadora y experiencia vital en "La afinadora de árboles" (2019), de Natalia Smirnoff
Authors: Valcheff García Fernando 
Published: September 2023

La afinadora de árboles (2019), largometraje escrito y dirigido por la cineasta argentina Natalia Smirnoff, narra la historia de Clara Mains (Paola Barrientos), una autora de literatura infantil que, luego de recibir un prestigioso premio internacional, intenta superar su bloqueo creativo reconectando con personas del pasado que la inspiran a esbozar un nuevo futuro. El presente trabajo explora la película de Smirnoff desde una perspectiva intermedial, abordando la articulación de la práctica creadora y trayectoria vital de la protagonista mediante un análisis del diálogo entre lenguajes, códigos y medios artísticos, y su vínculo con cruces y tensiones entre juventud y madurez, espacios privados y públicos, y producción individual y colectiva en el devenir de la cinta.
La afinadora de árboles [The Tree Tuner] (2019), written and directed by the Argentine filmmaker Natalia Smirnoff, depicts the story of Clara Mains (Paola Barrientos), a children’s literature author who, after receiving a prestigious international award, tries to overcome a creative block reconnecting with people from her past who inspire her to imagine a new future. This paper explores Smirnoff’s film from an intermedial perspective, addressing the articulation of the protagonist’s creative practice and life trajectory through an analysis of the dialogue between artistic languages, codes and media, and their links to the intersecting themes of–and tensions between–youth and maturity, private and public spaces, and individual and collective production.
Archivos de arcilla y afectos políticos en "Las Cautivas": Ejercicios para desarmar un monumento de Lucía Sbardella
Authors: Wetzel Agustina G. 
Published: September 2023

Este artículo propone algunas reflexiones en torno a la instalación de sitio específico Cautivas: ejercicios para desarmar un monumento de la artista correntina Lucía Sbardella. Sus ejercicios, a través de lo que analizamos bajo las nociones de contra monumentalidad y arte inespecífico, se encuentran vinculados a los efectos traumáticos de la Guerra del Paraguay. Sus esculturas de arcilla anticipan un rastro singular del trauma y su práctica reincorpora la vida afectiva en nuestras concepciones de la ciudadanía.

This article offers reflections upon Cautivas: ejercicios para desarmar un monumento, an installation by the artist Lucía Sbardella. It analyzes her practices according to notions of counter-monumentality and non-specific art, thinking about the traumatic effects related to the Paraguayan War. It proposes that her clay sculptures anticipate a singular trace of trauma and incorporate affective life into our conceptions of citizenship.
Pengembangan model pembelajaran kolary untuk permainan bolabasket di sekolah menengah atas
Authors: Shidiq Abdul Aziz Purnomo , Sukarmin Yustinus , Nikmah Rahmawati Al Adha 
Published: September 2023

Tujuan penelitian ini adalah untuk menghasilkan model pembelajaran kolary untuk permainan bolabasket di SMA. Pendekatan yang dilakukan dalam penelitian ini adalah penelitian dan pengembangan. Subjek penelitian ini adalah peserta didik sekolah menengah atas kelas X. Uji coba skala kecil dilakukan terhadap 32 peserta didik SMA N 1 Kartasura, dan 30 peserta didik SMA N 2 Sukoharjo. Uji coba skala besar dilakukan terhadap 32 peserta didik SMA N 1 Boyolali, 33 peserta didik SMA N 1 Banyudono, dan 36 peserta didik SMA N 2 Boyolali. Uji keefektifan dilakukan terhadap 32 peserta didik SMA N 7 Surakarta. Instrumen pengumpulan data yang digunakan yaitu: (1) pedoman wawancara, (2) pedoman observasi pembelajaran, dan (3) GPAI. Teknik analisis data yang dilakukan yaitu analisis deskriptif kuantitatif dan analisis deskriptif kualitatif. Hasil penelitian ini berupa model pembelajaran kolary untuk permainan bolabasket di SMA. Dari hasil penilaian para ahli dan praktisi, model pembelajaran kolary memiliki validitas 0,988 sehingga dapat ditarik kesimpulan bahwa model pembelajaran kolary yang disusun dapat meningkatkan keterampilan dribbling, passing, dan shooting dan aspek afektif yang terdiri atas kerja sama, disiplin, dan sportif. Di samping itu, model pembelajaran kolary juga sangat sesuai dengan karakteristik, pertumbuhan, dan perkembangan peserta didik serta mampu membuat peserta didik lebih mudah untuk mempelajari teknik dasar permainan bolabasket di SMA. Developing Kolary instructional model for basketball games in senior high school Abstract: This study aims to produce the Kolary instructional model for basketball games in senior high school. The approach taken in this study was research and development. The subjects were the tenth grade of high school. The preliminary field test was conducted on 32 students of the X grade in SMA N 1 Kartasura and 30 students of the X grade students of SMA N 2 Sukoharjo. The preliminary field test was conducted on 32 students of SMA N 1 Boyolali, 33 students of SMA Negeri 1 Banyudono, and 36 students of SMA N 2 Boyolali. The evaluation of the effectiveness was conducted on 32 students of SMA N 7 Surakarta. The data collection instruments used were: (1) interview, (2) observation learning guide, and (3) GPAI. The data were analyzed using quantitative descriptive analysis and qualitative descriptive analysis. The result of this research was a learning model Kolar for the game of basketball in high school. From the assessment results, experts' and practitioners' learning model Kolary has a validity of 0,988. It could be concluded that the learning model Kolary was drafted to improve the skills of dribbling, passing, and shooting and affective aspects consisting of cooperation, discipline, and sportsmanship. The learning models Kolar in accordance with the characteristics and growth and development of students, and students are able to make it easier to learn the basic techniques of basketball in high school.
Acceptability of the eHealth Intervention Sustainable Worker Digital Support for Persons With Chronic Pain and Their Employers (SWEPPE): Questionnaire and Interview Study
Authors: Svanholm Frida , Turesson Christina , Löfgren Monika , Björk Mathilda 
Published: September 2023

Background
Sick leave and decreased ability to work are the consequences of chronic pain. Interdisciplinary pain rehabilitation programs (IPRPs) aim to improve health-related quality of life and participation in work activities, although implementing rehabilitation strategies at work after IPRPs can be difficult. Employers’ knowledge about pain and the role of rehabilitation needs to be strengthened. The self-management of chronic pain can be improved through eHealth interventions. However, these interventions do not involve communicating with employers to improve work participation. To address this deficiency, a new eHealth intervention, Sustainable Worker Digital Support for Persons with Chronic Pain and Their Employers (SWEPPE), was developed.

Objective
This study aimed to describe the acceptability of SWEPPE after IPRPs from the perspective of patients with chronic pain and their employers.

Methods
This study included 11 patients and 4 employers who were recruited to test SWEPPE in daily life for 3 months after IPRPs. Data were collected using individual interviews at the end of the 3-month test period and questionnaires, which were completed when SWEPPE was introduced (questionnaire 1) and at a 3-month follow-up (questionnaire 2). Data were also collected on how often SWEPPE was used. Qualitative data were analyzed through a qualitative content analysis using an abductive approach. The framework used for the deductive approach was the theoretical framework of acceptability. Quantitative data were analyzed through descriptive statistics and the differences between the responses to questionnaires 1 and questionnaire 2 using the Wilcoxon signed rank test.

Results
Both patients and employers reported that SWEPPE increased their knowledge and understanding of how to improve work participation and helped them identify goals, barriers, and strategies for return to work. In addition, participants noted that SWEPPE improved employer-employee communication and collaboration. However, experiences and ratings varied among participants and the different SWEPPE modules. The acceptability of SWEPPE was lower in patients who experienced significant pain and fatigue. A high degree of flexibility and choice of ratings in SWEPPE were generally described as helpful.

Conclusions
This study shows promising results on the user acceptability of SWEPPE from both patient and employer perspectives. However, the variations among patients and modules indicate a need for further testing and research to refine the content and identify the group of patients who will best benefit from SWEPPE.
Respons i fokus. Lärares normer och attityder till andraspråksdrag i studenttexter
Authors: Eklund Heinonen Maria , Nyroos Lina 
Published: September 2023

Under två decennier har högre utbildning haft breddad rekrytering som målsättning, vilket har fört med sig nya och mer heterogena studentgrupper. En av dessa är studenter med annat modersmål än svenska, och återkommande tenderar deras skrivförmåga att fokuseras i debatten. Att skrivande är sammankopplat med det sociala sammanhang där skrivandet sker har beskrivits väl inom fältet Academic Literacies. I den här artikeln presenteras en studie med fokus på lärares attityder och förhållningssätt till andraspråksstudenters skrivande. Syftet med studien är att belysa normer som präglar skrivandets sammanhang, för att på så vis få en bättre bild av de förutsättningar som präglar och omgärdar andraspråksstudenters skrivande i olika ämnen under deras utbildningsprogram. För att undersöka detta har lärares skriftliga respons som rör språket analyserats med avstamp i teorier om respons. De lärare som skrivit responsen har också intervjuats om sin respons med hjälp av stimulated recall-teknik. Resultaten visar att lärarnas respons präglas av deras egna erfarenheter, syn på skrivprocessen samt den egna rollen inom utbildningen. Sammantaget visar undersökningen att bristen på kollegial samsyn mellan ämnen inom programmet ger utrymme för parallella normer att existera, vilket resulterar i att studenterna möter ett brett spann av förväntningar på hur texter ska utformas.
ENGLISH ABSTRACT
Response in focus. Teachers’ norms and attitudes towards second language structures in student texts
For two decades, it has been a statutory provision in the Higher Education Act to strive for widening participation. This has led to new and more diverse student groups, one of which being students with a mother tongue other than Swedish. Recurrently, their writing ability tends to be focused in the debate. In the field of Academic Literacies, writing is considered to be a socioculturally rooted practice, in which teachers’ attitudes strongly impact the writing process. This article presents a study of teachers’ attitudes towards second language students’ writing, aiming to shed light on norms and conditions surrounding L2 students’ academic writing. Teachers’ written feedback concerning linguistic features has been analysed based on theories on feedback practices. The same teachers have also been interviewed regarding their feedback, using stimulated recall-technique. The results show that the teachers’ feedback reflect different perspectives on the writing process, as well as their own role in the education system. In sum, the study shows that the lack of collegial consensus allows for parallel norms to exist, which results in the students within the same educational program being exposed to a wide range of expectations regarding how texts ought to be written.
Analisis komponen bioaktif dan atribut sensori seduhan kopi Arabika Kalosi Enrekang dengan pengolahan pascapanen berbeda [Analysis of bioactive compounds and sensory attributes of Kalosi-Enrekang Arabica coffee prepared different postharvest processing]
Authors: Yulianti Yulianti , Adawiyah Dede Robiatul , Herawati Dian , Indrasti Dias , Andarwulan Nuri 
Published: September 2023

Postharvest processing affects the chemical components and sensory attributes of coffee beans. This study aimed to evaluate the effect of postharvest processing on caffeoylquinic acids and alkaloids (bioactive compounds) and sensory attributes (aroma and taste) of brewed coffee. Coffee beans of Kalosi-Enrekang were processed using three postharvest processing methods (honey, natural, and full-washed), roasted at a medium degree, and brewed with tubruk brewing techniques. Bioactive compounds were analyzed using UPLC-PDA and sensory attributes were analyzed using the Quantitative Descriptive Analysis method. The data were analyzed using single-factor ANOVA and Principal Component Analysis. The research showed that postharvest processing did not affect the bioactive compound of brewed coffee. Postharvest processing affected the aroma and taste attributes of brewed coffee. Natural processing had dominant attributes of fruity, spicy, sweet, and caramelized. Honey processing had dominant attributes of nutty and roasted, while full-washed processing did not have dominant attributes. The result also showed that caffeoylquinic acids and alkaloids did not affect coffee brewed's aroma and taste attributes.
Profil gelatinisasi, karakteristik mikrobiologi dan sifat fungsional pati jagung ketan terfermentasi [Gelatinization profile, microbiological characteristics and funtional properties of fermented waxy corn starch]
Authors: Une Suryani , Killa Rizky , Ahmad Lisna , Antuli Zainudin , Panggi Husain 
Published: September 2023

Waxy corn (AJU1) is widely cultivated in Gorontalo Province, but its utilization is limited to corn on cobs. A potential diversified product of processed waxy corn to be developed is waxy corn starch. One simple method to improve the functional properties of waxy corn starch is fermentation. This study aimed to determine the effect of different fermentation conditions and fermentation times on the gelatinization profile and functional properties of waxy corn starch. The research method used a completely randomized factorial design with two treatment factors namely fermentation conditions (aerobic and anaerobic) and fermentation time (3, 6, and 9 days). Results showed that the fermentation conditions significantly affected property of waxy corn starch. During fermentation, there was a change in the number of cells of lactic acid bacteria, yeast, and mold. The gelatinization profile of fermented waxy corn starch was to have resistant to stirring and high temperatures and reduced its retrogradation tendency. The fermentation process also changed the functional properties of glutinous corn starch, namely an increase in solubility, swelling, and acidity (decrease in pH).Keywords: aerobic, anaerobic, fermentation, starch, glutinous corn [AJU1]
Çanakkale Cephesi’ne Ait Yeni Askerî Veriler Işığında Kayıp Şehitler ve Kayıp Bir Batarya Şehitliğinin Tespiti
Authors: KARATAŞ Murat 
Published: September 2023

Milli Savunma Bakanlığı tarafından 1998 yılında yayınlanan beş ciltlik Şehitlerimiz isimli eser, arşiv kayıtlarına göre hazırlanması bakımından konu ile ilgili ana kaynak olarak kullanılan en temel eserler arasındadır. Ancak savaşlar zamanında tutulan harp cerideleri ile diğer askerî ve resmî evraklara yansıyan şehitlere dair veriler de ana kaynak niteliğindedir; birinci el rafine bilgi sağlamaktadır.
Bu makalede, Birinci Dünya Savaşı sırasında Çanakkale Cephesi’ndeki İntepe-Çakaltepe mıntıkasında görevli iken şehit olanlara dair Milli Savunma Bakanlığı tarafından yayınlanan Şehitlerimiz isimli eserdeki veriler ile 1915 yılına dair Osmanlı askeri arşiv belgelerinde yeni ortaya çıkan verilerin karşılaştırılması yoluyla aradaki farklar ortaya çıkarılmış; bu yolla, eksik veya hatalı bilgilerin giderilmesi amaçlanmıştır. Ayrıca günümüzde bahsi geçen mıntıka içerisinde mevcut olmayan ancak 1915 yılında mevcut olduğu anlaşılan bir Batarya Şehitliği hakkında yeni tarihsel askerî veriler sunulmuştur.
KONSEP MAQASID AS SYARIAH DALAM PERBANKAN SYARIAH
Authors: Alwi Muhammad , Kara Muslimin , Abdullah M. Wahyuddin , Fachrurrazy Muhammad 
Published: September 2023

Artikel ini memiliki tujuan mendeksripsikan mekanisme perbankan syariah, konsep maqasid syariah dan implementasi maqasid syariah pada perbankan syariah. Kajian dalam penelitian ini menggunakan metode penelitian perpustakaan (library research). Di mana sumber data utama dikaji dari berbagai sumber relavan dengan tema kajian baik dari jurnal ilmiah, buku dan berbagai sumber lain yang mendukung. Kajian penelitian mengungkapakan bahwa Perbankan syariah dalam menjalankana kegiatan bisnis syariah mengaju pada ketentuan undang-undang perbankan syariah Pasal 1 ayat 20-25 dan ayat 28, terkait tentang Simpanan, Pembiayaan, dan jasa yang ditawarkan perbankan syariah. Selain itu perbankan syariah juga menerima dan mengelola dana zakat, infaq dan sedekah, hibah dan wakaf. Konsep maqasid syariah yaitu mengaju pada kemaslahatan sebagaimana tujuan syariat itu sendiri, Imam Syatibi merumuskan konsep maqasid menjadi tiga yaitu, yaitu: Dharuriyat, Hajiyat dan Tahsiniyat. sementara konsep maqasid syariah yang ditawarkan oleh Abu Sahra membagi dalam tiga aspek yaitu Tahzibul Fardi (Mendidik Individu), Iqamah al Adl (Menegakan Keadilan), dan Maslahah (Public Interest). Implementasi konsep maqasid syariah pada PT. Bank Muamalat sudah diterapkan dengan baik maqasid syariah pada PT Bank Muamalat Indonesia sudah diterapkan, selain itu program kerja CSR BRI Syariah menjadi indikator pelaksanana konsep maqasid syariah dan mengalami peningkatan setiap tahunnya. Perbankan syariah di Indonesia pada tahun 2017-2020 berdasarkan indeks maqasid syariah menununjukkan capaian kinerja yang baik.