bluuebunny/crossref_metadata_2025_split huggingface dataset:
ФРАУДАТОРНІ УГОДИ В ГОСПОДАРСЬКОМУ СУДОЧИНСТВІ. СУДОВА ПРАКТИКА
Authors: Дяченко С. В. , Динюк А. А. 
Published: December 2023

У статті досліджено теоретичні та практичні аспекти застосування конструкції фраудаторних угод у справах про банкрутство. Звертаємо увагу, що законодавством України про банкрутство встановлено важливий правовий інструмент – визнання правочинів боржника, вчинених у так званий підозрілий період, недійсними (ст. 42 Кодексу України з процедур банкрутства, далі – КУзПБ). Метою його застосування є збільшення ліквідаційної маси боржника шляхом повернення майна, переданого іншим особам з метою захисту інтересів кредиторів.
Розглянули особливості недійсності правочинів боржника під час застосування різних судових процедур у разі банкрутства. Автор підкреслив, що на етапі пред’явлення та оцінки вимог кредиторів вони виявляють високу активність, яка полягає не лише в пред’явленні власних вимог, а й в активному оскарженні вимог інших кредиторів. Встановлено, що інститут недійсності дій боржника по-різному проявляється на окремих стадіях застосування провадження у справі про банкрутство до боржника-банкрута, що визначається цілями та завданнями відповідного провадження. Доведено, що у провадженні щодо розпорядження майном боржника та у провадженні санації наявні інші підстави для визнання недійсними правочинів боржника – це вчинення значних правочинів без згоди комітету (зборів) кредиторів.
Інститут недійсності правочинів боржника у процесі застосування майнового процесу, особливо під час попереднього засідання, спрямований на недопущення визнання вимог кредиторів, що виникли на підставі фіктивних та удаваних правочинів, з метою штучного збільшення зобов’язань. У процедурах реструктуризації основною метою застосування інституту недійсності правочинів боржника є відновлення платоспроможності боржника. Метою визнання недійсними документів боржника в ліквідаційній процедурі є максимізація ліквідаційної маси та задоволення якомога більшої кількості вимог за ці кошти.
ПРАВОВЕ РЕГУЛЮВАННЯ ДЕФІЦИТУ БЮДЖЕТУ УКРАЇНИ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Касьяненко Л. М. , Миколаєнко П. М. , Підгородецький В. О. 
Published: December 2023

У статті досліджено аспекти правового регулювання дефіциту бюджету України в умовах повномасштабної війни. Зокрема, визначено дефініцію поняття «дефіцит бюджету» з урахуванням офіційного визначення та науковців, зазначено те, що серед учених-економістів та юристів досі немає єдиної думки щодо цього терміна. Зосереджується увага на тому, що бюджетний дефіцит, попри свою негативність, не завжди є критичним явищем, у світовій практиці високорозвинені країни також мають бюджеті дефіцити. Здійснюється класифікація найпоширеніших причин, які спричиняють дефіцит бюджету. Проведено аналіз взаємозалежності між дефіцитом бюджету та державним боргом.

© Вітюк Р. В., Лупай А. С., Скрипець В. І.., 2023

Проаналізовано дефіцит бюджету у відсотках щодо ВВП. Акцентовано на відношенні сальдо виконання державного бюджету у паралелі січня 2023 та 2022 років. Враховуючи дослідження науковців, виділено основні можливості щодо скорочення дефіциту бюджету. Розглянуто джерела фінансування бюджету відповідно до Бюджетного кодексу України, до яких належать: кошти від внутрішніх та зовнішніх запозичень; кошти від приватизації державного майна, повернення бюджетних коштів з депозитів та ін. Зосереджено особливу увагу на доходах до держбюджету від випуску військових облігацій та іноземних інвестицій у період воєнного стану. Наголошено на важливості правового врегулювання питання у можливості розумного продажу державного та комунального майна для покращення залучення іноземних інвестицій у структуру економіки України.
Зосереджується увага, що нині бюджетний дефіцит для нашої держави є досить важкою частиною фінансово-правової політики, зокрема через повномасштабну війну, оскільки значні видатки спрямовані на досягнення перемоги над агресором.
Обґрунтована думка, що для покращення позицій держави щодо боргових зобов’язань необхідно удосконалювати законодавчу базу, яка чітко регулюватиме ці питання. Посилення правового регулювання державного боргу у сфері оптимізації співвідношення обсягів, структури та джерел його погашення.
Переконані у важливості продовження досліджень у сфері правового регулювання дефіциту бюджету.
The Influence of Autonomy, Competence, Relatedness, and Technostress on Performance Expectations in Digital Transformation of Public Broadcasting Institutions in Indonesia
Authors: Saraswaty Amelia Regita , Pusparini Elok Savitri 
Published: December 2023

Abstract

Digital transformation is an emerging technological phenomenon that profoundly influences various aspects of work within an organization. In this context, the willingness of employees to consistently contribute to a digitally transformed workplace becomes crucial in the overall transformation process. Therefore, this study aimed to determine the influence of autonomy expectations, competence, relatedness, and technostress on employees' performance expectations. It involved permanent employees of LPP TVRI who have been working for a minimum of 2 years and the data were collected using a questionnaire. Furthermore, a total of 238 respondents were included in the study and the data was analyzed using Partial Least Square (PLS-SEM). The results showed a positive influence between expectations of autonomy, competence, and relatedness to performance but technostress had no significant effects on the variable. This study provided insights for practitioners in the public sector, specifically in the broadcasting media, regarding how employees’ performance was shaped by autonomy, competence, relatedness, and technostress.

Keywords: Performance; Competence; Autonomy; Technostress; Digital Transformation; Public Broadcasting Institutions

Abstrak

Transformasi digital adalah fenomena teknologi baru yang sangat memengaruhi berbagai aspek pekerjaan dalam suatu organisasi. Dalam konteks ini, kemauan karyawan untuk secara konsisten berkontribusi pada tempat kerja yang bertransformasi secara digital menjadi sangat penting dalam keseluruhan proses transformasi. Oleh karena itu, penelitian ini bertujuan untuk mengetahui pengaruh otonomi ekspektasi, kompetensi, keterkaitan, dan technostress terhadap ekspektasi kinerja karyawan. Melibatkan pegawai tetap LPP TVRI yang telah bekerja minimal 2 tahun dan data dikumpulkan dengan menggunakan kuesioner. Selanjutnya, sebanyak 238 responden dilibatkan dalam penelitian dan data dianalisis menggunakan Partial Least Square (PLS-SEM). Hasil penelitian menunjukkan adanya pengaruh positif antara ekspektasi otonomi, kompetensi, dan keterkaitan terhadap kinerja tetapi teknostres tidak berpengaruh signifikan terhadap variabel tersebut. Studi ini memberikan wawasan bagi para praktisi di sektor publik, khususnya di media penyiaran, mengenai bagaimana kinerja pegawai dibentuk oleh otonomi, kompetensi, keterkaitan, dan technostress.

Kata Kunci: Kinerja; Kompetensi; Otonomi; Technostress; Transformasi Digital; Public Broadcasting Institutions
Analyzing the Interconnected Influence of Profitability and Capital Structure on Firm Value (A Case Study of State-Owned Companies in the Construction Sector TBK From 2016-2020)
Authors: Supyan Salsabila Muslifah Adinda , Kuswanto Arif 
Published: December 2023

Abstract

State-owned companies operating in the construction sector are known to incur substantial and accumulating debt. This is attributed to the use of the capital structure through debt loans or external funding, often from foreign parties with multi-year payment terms. Therefore, this study aimed to identify and comprehensively analyze the reciprocal relationship between profitability and the capital structure, examining its impact on firm value. The array is specifically focused on State-Owned Companies in the Construction Sector over the period from 2016 to 2020. A quantitative approach was adopted in the selected methodology, with financial data extracted from 40 reports. The data analysis used various methods, including the Granger Causality, t-test, and Determination Test. The results showed a significant impact of profitability on the capital structure, and vice versa while showing a substantial influence on firm value. Additionally, the capital structure significantly impacted firm value in State-Owned Companies in the Construction Sector from 2016 to 2020.

Keywords: Profitability, Capital Structure, Firm Value.

Abstrak

Perusahaan BUMN sektor kontruksi terindikasi adanya utang yang besar dan menumpuk. Hal ini disebabkan perusahaan karya menggunakan struktur modalnya dari pinjaman hutang atau pendanaan dari pihak luar atau asing dengan Multi year payment. Penelitian ini bertujuan untuk mengetahui dan menganalisis hubungan timbal balik antara profitabilitas dan struktur modal serta dampaknya terhadap nilai perusahaan (Studi pada perusahaan BUMN Sektor Kontruksi Tahun 2016-2020). Metode yang digunakan adalah kuantitatif dengan menggunakan 40 data laporan keuangan dan Teknik Analisis data yang digunakan adalah Uji Kausalitas Granger, Uji t dan Uji Determinasi. Hasil penelitian menunjukan profitabilitas berpengaruh signifikan terhadap struktur modal pada perusahaan BUMN Sektor Kontruksi Tbk tahun 2016-2020, Struktur modal berpengaruh signifikan terhadap profitabilitas pada Perusahaan BUMN Sektor Kontruksi Tbk tahun 2016-2020, Profitabilitas berpengaruh signifikan terhadap nilai perusahaan pada Perusahaan BUMN Sektor Kontruksi Tbk tahun 2016-2020, Struktur modal berpengaruh signifikan terhadap nilai perusahaan pada Perusahaan BUMN Sektor Kontruksi Tbk tahun 2016-2020.

Kata kunci: Profitabilitas; Struktur Modal; Nilai Perusahaan
Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability
Authors: Wang Jiayu , Liu Yixuan , Tian Peiqing , Xing Liyun , Huang Xianwei , Fu Caihua , Xu Xiangyu , Liu Ping 
Published: December 2023

BackgroundTo investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability.Methods701 patients were divided into stable coronary artery disease (SCAD), ACS, and control groups. Furthermore, 225 patients who underwent carotid ultrasound were selected from the above 701 patients and were divided into low-risk plaque, medium-to-high risk plaque, and control (without carotid plaques) groups. We collected their baseline characteristics and measured the contents of exosomal circSCMH1 and miR-874 in peripheral blood. Then lg(circSCMH1/miR-874) was calculated and statistical analysis was performed.ResultsThe lg (circSCMH1/miR-874) values of ACS, SCAD, and the control group decreased successively (P &lt; 0.05). Compared with the low-risk plaque and control groups, the lg (circSCMH1/miR-874) value of medium-high risk plaque group decreased (P &lt; 0.05). Multivariate logistic regression analysis showed that with the decrease of lg (circSCMH1/miR-874), the risk of ACS, AMI, and medium-high risk plaques increased. ROC curve analysis demonstrated that lg (circSCMH1/miR-874) has a higher diagnostic value for ACS, AMI and medium-high risk plaques than previously used predictive ratios.ConclusionLg (circSCMH1/miR-874) is closely associated with coronary and carotid plaque stability.
The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study
Authors: Yan Ming , Xiao Li-yuan , Gosau Martin , Friedrich Reinhard E. , Smeets Ralf , Fu Ling-ling , Feng Hong-chao , Burg Simon 
Published: December 2023

IntroductionThe coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and genital herpes. Several clinical case reports have declared a possible association between the two, however, the causal relationship between them has not been clarified.MethodsThis study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.ResultsMR analysis exhibited that COVID-19 infection was relevant to a reduced risk of HSV1 infection (p=7.603239e−152, OR=0.5690, 95%CI=0.5455−0.5935, IVW). Regarding the effect of COVID-19 infection on HSV2, MR analysis suggested that COVID-19 infection was correlated with an augmented risk of HSV2 infection (p=6.46735e−11, OR=1.1137, 95%CI=1.0782−1.1502, IVW). The reverse MR analysis did not demonstrate a reverse causal relationship between HSV and COVID-19. DiscussionAltogether, COVID-19 infection might cause a decreased risk of HSV1 infection and an elevated risk of HSV2 infection.
Leveraging diverse cell-death related signature predicts the prognosis and immunotherapy response in renal clear cell carcinoma
Authors: Wu Zhengqi , Jin Mingyue , Xin Peng , Zhang Hao 
Published: December 2023

BackgroundModulation of programmed cell death in tumor cells alters the tumor microenvironment and the influx of tumor-infiltrating lymphocytes, and the combination of its inducers and immune checkpoint inhibitors plays a synergistic role in enhancing antitumor effects.MethodsWe downloaded the data of clear cell renal cell carcinoma samples from The Cancer Genome Atlas and used a machine learning approach to build a new programmed cell death index (PCDI) through 13 programmed cell death-related genes. Based on PCDI, clinical features, tumor immune microenvironment, chemotherapy response and immunotherapy response were systematically analyzed.ResultsPCDI consists of eight programmed cell death-related genes (TBX3, BID, TCIRG1, IDUA, KDR, PYCARD, IFNG and LRRK2). PCDI is a reliable predictor of survival in clear cell renal cell carcinoma patients and has been validated in multiple external datasets. We found that the high PCDI group showed higher levels of immune cell infiltration and better response to immunotherapy compared to the low PCDI group, and PCDI can also be used for prognostic prediction in a variety of cancers other than clear cell renal cell carcinoma. In vitro experiments demonstrated that knockdown of IDUA inhibited the proliferation and migration of clear cell renal cell carcinoma.ConclusionsThe PCDI identified in this study provides valuable insights into the clinical management of clear cell renal cell carcinoma by accurately evaluating the prognosis of patients with clear cell renal carcinoma and identifying the patient population that would benefit from immunotherapy.
Circulating levels of cytokines and risk of inflammatory bowel disease: evidence from genetic data
Authors: Liu Bin , Qian Yu , Li Yanan , Shen Xiangting , Ye Ding , Mao Yingying , Sun Xiaohui 
Published: December 2023

BackgroundPrior epidemiological studies have established a correlation between inflammatory cytokines and inflammatory bowel disease (IBD). However, the nature of this relationship remains uncertain. Mendelian randomization (MR) study has the advantages of avoiding confounding and reverse causality compared with traditional observational research.ObjectiveWe aimed to evaluate whether genetically determined circulating levels of cytokines are associated with the risk of IBD by using the MR approach.Materials and methodsWe selected genetic variants associated with circulating levels of 28 cytokines at the genome-wide significance level from a genome-wide association study (GWAS) including 8,293 individuals. Summary-level data for IBD (including Crohn’s disease and ulcerative colitis) were obtained from the International Inflammatory Bowel Disease Genetics Consortium and UK Biobank. We performed the primary analysis using the inverse-variance weighted method, as well as sensitivity analyses to test the stability of our results. We subsequently replicated the results of IBD in the UK Biobank dataset. A reverse MR analysis was also conducted to evaluate the possibility of reverse causation.ResultsGenetically predicted elevated levels of interleukin-17 (IL-17) and monokine induced by interferon-gamma (MIG) were associated with an increased risk of IBD[odds ratio (OR): 1.52, 95% confidence interval (CI):1.10-2.08, P =0.010 for IL-17 and OR: 1.58, 95% CI: 1.24-2.00, P = 1.60×10-4 for MIG]. Moreover, we observed suggestive associations between β-NGF and MIP-1β with the risk of Crohn’s disease (OR: 0.71, 95% CI: 0.52-0.98, P = 0.039) and ulcerative colitis (OR: 1.08, 95% CI: 1.01-1.15, P= 0.019). In the reverse MR study, there was no evidence of causal effects of IBD and these cytokines.ConclusionOur study suggests the potential causal associations of IL-17 and MIG with IBD. Further studies are needed to determine whether IL-17 and MIG or their downstream effectors could be useful in the management of IBD.
Ultrasound characterization of superficial lymph nodes in HIV patients with Talaromyces marneffei infection
Authors: Pan Lin , Shao Huaguo 
Published: December 2023

ObjectivesThis study aimed at exploring the ultrasound characteristics of superficial lymph nodes (LNs) in HIV patients with Talaromyces marneffei infection to provide assistance and understanding for diagnosis and therapy.MethodsA retrospective analysis was conducted on 26 patients with confirmed HIV and T.marneffei coinfection. These patients underwent ultrasound examination and ultrasound-guided puncture biopsies at our hospital from March 2015 to March 2023.ResultsIn all 26 patients, lymphadenectasis was observed. Among the 21 cases (80.76%), LNs showed a diffusely hyperechoic appearance with a tulle-like change, and 6 cases (23.07%) showed liquefaction. When the hila were present or thinned, the blood flow signals were primarily hilar, whether rich or poor, and when the hila were absent, the blood flow signals were peripheral or poor. The axillary LN long-to-short diameter (L/S) ratios exhibited a significant positive correlation with CD4+T cell counts (r = 0.8214, p = 0.0341). Patients with retroperitoneal lymphadenectasis showed decreased NK cell counts (p = 0.03).ConclusionIn summary, the T.marneffei infection of LNs in HIV patients often manifests with superficial LN enlargement, mostly affecting the cervical LNs. The T.marneffei-infected LNs exhibit several characteristics such as echogenicity, hilum, and blood flow signal. Furthermore, there might be associations between lymphocyte subsets and enlarged superficial LNs. Ultrasound examinations should be paid attention to if patients have superficial LN enlargement, and the diagnosis of the T.marneffei infection is considered.
A prognostic model based on prognosis-related ferroptosis genes for patients with acute myeloid leukemia
Authors: Wu Feima , Xu Guosheng , Li Guangchao , Yin Zhao , Shen Huijuan , Ye Kaiheng , Zhu Yangmin , Zhang Qing , Ou Ruiming , Liu Shuang 
Published: December 2023

Background: Acute myeloid leukemia (AML) is a heterogeneous disorder with an unpredictable prognosis. Ferroptosis, the iron-dependent cell death program, could serve as an alternative for overcoming drug resistance. However, its effect on AML remains largely unclear.Methods: We collected RNA sequencing data and relevant clinical information of AML patients from The Cancer Genome Atlas to construct a prognosis prediction model. Risk score was calculated with eight prognosis-related ferroptosis genes (PRFGs) discovered through univariate analysis and Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression. A nomogram was constructed by incorporating LASSO risk score, age, and cytogenetic risk based on univariate/multivariate Cox regression.Results: Of the 33 AML PRFGs identified from the TCGA-derived dataset, 8 genes were used to construct a gene signature to predict AML prognosis. Principal component analysis and heatmap showed significant differences between the low and high risk score groups. Next, LASSO risk score, age, and cytogenetic risk were incorporated into the nomogram to predict the overall survival (OS) of AML patients. According to survival analysis, patients with a low risk score had markedly increased OS as compared to those with a high risk score. Based on the results of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, the differences between the two risk groups showed a close relationship with immune-related pathways and membrane transportation. The analysis of tumor-infiltrating immune cells and immune checkpoints revealed that the immunosuppressive tumor microenvironment possibly facilitated different prognostic outcomes between the two groups. Gene expression analyses showed that the mRNA expression levels of PARP1 and PARP3 (PARPs) were closely related to the different clinical subgroups and the analyzed OS in AML patients. Finally, the PARP inhibitor talazoparib and the ferroptosis inducer erastin exerted a synergistic anti-proliferative effect on AML cells.Conclusion: We constructed a nomogram by incorporating PRFGs, and the constructed nomogram showed a good performance in AML patient stratification and prognosis prediction. The combination of PARP inhibitors with ferroptosis inducers could be a novel treatment strategy for treating AML patients.
Prevalence of malnutrition and its associated factors among 18,503 Chinese children aged 3–14 years
Authors: Zhang Xiaoqian , Wang Qiong , Gao Ziyu , Zhang Zifeng , Wu Jing , Zhang Zhixin , Niu Wenquan 
Published: December 2023

BackgroundChild malnutrition places a major burden on global public health. We aimed to estimate the prevalence of child malnutrition and identify its potential factors among children aged 3–14 years from Beijing and Tangshan.MethodsWe cross-sectionally recruited 18,503 children aged 3–14 years from September 2020 to January 2022, according to a stratified cluster random sampling strategy. Child malnutrition was defined according to the World Health Organization criteria. Data were analyzed by STATA software and R language.ResultsThe prevalence of malnutrition among 18,503 children was 10.93%. After multivariable adjustment, seven factors significantly associated with child malnutrition were parental education (adjusted odds ratio, 95% confidence interval, p: 1.52, 1.40 to 1.67, &lt;0.001), family income (1.23, 1.16 to 1.30, &lt;0.001), fast food intake frequency (1.14, 1.06 to 1.21, &lt;0.001), night meals intake frequency (1.09, 1.04 to 1.15, &lt;0.001), eating speed (1.01, 1.01 to 1.02, &lt;0.001), maternal obesity (0.97, 0.95 to 0.99, &lt;0.001), and paternal obesity (0.97, 0.96 to 0.98, &lt;0.001). The seven significant factors had better prediction performance (area under the receiver operating characteristic, 0.956) for child malnutrition.ConclusionApproximately 10% of Chinese children aged 3–14 years were in malnutrition status, and seven factors were found to be significant predictors for child malnutrition.