bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Feasibility Study Investigating an Exercise Program in Metastatic Cancer Based on the Patient-Preferred Delivery Mode
Authors: Avancini Alice , Borsati Anita , Baldo Elisabetta , Ciurnelli Christian , Trestini Ilaria , Tregnago Daniela , Belluomini Lorenzo , Sposito Marco , Insolda Jessica , Auriemma Alessandra , Fiorio Elena , Piacentini Michela , Schena Federico , Milella Michele , Pilotto Sara 
Published: January 2024

Abstract

Background
Feasibility of exercise in patients with metastatic cancer is still a challenge. This study aimed to determine the feasibility and preliminary efficacy of an exercise intervention based on a patient-preferred delivery mode in patients affected by metastatic cancer.

Materials and Methods
Forty-four patients with a confirmed diagnosis of metastatic cancer were recruited in a 3-month exercise program. Whereas the exercise program consisted of aerobic and resistance activities performed twice a week, the participants may choose the mode of delivery: home based, personal training, or group based. The primary endpoint was the feasibility, defined by recruitment rate, attendance, adherence, dropout rate, tolerability (comparing the session RPE with the target RPE), and safety (using the Common Terminology Criteria for Adverse Events, version 5.0). Secondary endpoints included cardiorespiratory fitness (six minutes walking test), muscle strength (handgrip strength test and isometric leg press test), flexibility (the back scratch and chair sit and reach tests), anthropometric parameters (body mass index and waist-hip ratio), quality of life (EORTC QLQ C-30 questionnaire), and amount of physical exercise (Godin’s Shepard Leisure Time Exercise Questionnaire). Descriptive statistics, Student t test, and Wilcoxon signed rank test were used to analyze data.

Results
The study recruitment rate was 81%. Out of 44 recruited patients, 28 chose the personal training program, 16 chose the home-based program, and none chose the group-based program. Nine dropouts occurred (20%), 6 in the personal training program, and 3 in the home-based intervention. The median attendance rate was 92%, adherence was 88%, tolerability was 100%, and 9 nonsevere adverse events were registered during the exercise sessions. An increase in cardiorespiratory fitness (P &lt; .001) and flexibility (P = .011 for chair sit and reach; P = .040 for back scratch) was observed at the end of the intervention, while no changes in anthropometric values and muscle strength were detected. Different quality-of-life domains were improved following the intervention, including physical (P = .002), emotional (P &lt; .001), and role functioning (P = .018), fatigue (P = .030), and appetite loss (P = .005).

Conclusion
A 3-month exercise program based on a patient-preferred delivery mode is feasible in patients with metastatic cancer and may improve physical function and quality of life.

Trial Registration
NCT04226508
Association Between Length of Maternity Leave and Breastfeeding Duration in the United States
Authors: Wicklund Lorena , Epstein Allison , Szugye Heidi , Schleicher Mary , Lam Suet Kam 
Published: January 2024

OBJECTIVE:
To perform a systematic review to assess the association between the length of maternity leave and breastfeeding duration in the United States.

DATA SOURCES AND METHODS OF STUDY SELECTION:
This review was conducted with a five-stage model for reviews. We included publications from 2000 to 2023, U.S.-based studies written in English, and primary research and peer-reviewed articles. In February 2023, a medical librarian conducted a search across seven databases, yielding 1,540 results. ClinicalTrials.gov was later searched, yielding no results. After duplicates were removed, 835 abstracts were screened. A full-text article review was then conducted of the remaining 34 articles.

TABULATION, INTEGRATION, AND RESULTS:
Twenty-three articles met inclusion criteria, two of which were reviews. Of the nonreview articles, all found a positive relationship between increased maternity leave and duration of breastfeeding. Data showed that earlier return to work for the birth parent decreased the odds of breastfeeding dyads meeting breastfeeding recommendations. Many studies adjusted for confounders (eg, race, socioeconomic status); however, Black or Latinx mothers still experience shorter breastfeeding durations or lower breastfeeding exclusivity when given equal leave compared with White mothers.

CONCLUSION:
Results show a positive relationship between length of maternity leave and breastfeeding duration. Advocacy for longer, paid parental leave and more robust research rooted in rigorous methods are needed.
Preliminary experience with 18 months result of endoscopic sleeve gastroplasty from an Asian population: Learning curve of one bariatric surgeon
Authors: Chen Sheng-Shih , Lee Wei-Jei , Kang Lung-Yun , Chou Chu-Kung 
Published: January 2024

Abstract

Background
Endoscopic sleeve gastroplasty (ESG) is emerging as an innovative approach to treating obesity. It provides a bridge between surgical and medical treatments for obesity. Nevertheless, the majority of reports on ESG originate from Western countries, and there is a lack of data from Asian nations. This study aims to share our pioneering experience with this novel technique in Asia.

Materials and Methods
We enrolled obese patients with a body mass index greater than 27 kg/m2 who were at least 20 years old. ESG was conducted following a comprehensive preoperative assessment. Following the procedure, patients were scheduled for regular outpatient department follow-up appointments at 7 days, 1 month, 2 months, 3 months, and then every 3 months up to 18 months postoperation. Body weight and any adverse events were documented during each follow-up visit.

Results
A total of 49 obese patients were enrolled in this study. Our findings demonstrate that ESG can be safely integrated into a conventional bariatric surgery center, with a learning curve observed after 10 cases in this study. In our series, the results showed that total body weight loss (TBWL) reached 7% at 1 month, 9% at 3 months, 14% at 6 months, 16% at 12 months, and 18.6% at 18 months. No adverse events or complications were reported in the study; however, five patients experienced procedure failures. Four of these patients underwent a repeat ESG, whereas one patient opted for surgical intervention.

Conclusions
ESG can be used in Asian countries, and the effectiveness of weight loss has proven to be satisfactory.
Extended Partington procedure for chronic pancreatitis: One-year follow-up results
Authors: Mai Dai Nga , Nguyen Quoc Vinh , Phan Minh Tri , Doan Tien My 
Published: January 2024

Abstract

Background
Over half of the patients who underwent the Partington procedure for painful chronic pancreatitis developed recurrent pain attacks. This occurs because the proximal ducts at the head of the pancreas, often containing stones, are left undrained. To overcome this pitfall, an extended Partington procedure is recommended. The aim of this study was to assess our 1-year follow-up results of the extended Partington procedure in patients with painful chronic pancreatitis.

Materials and Methods
This prospective study comprises patients undergoing extended Partington procedures who were followed for at least 1 year. Data were collected preoperatively and postoperatively in a fixed-interval fashion at 3 months, 6 months, and 1 year.

Results
Thirty-one patients underwent assessment. At 1-year follow-up, effective and complete pain relief was achieved in 81% and 55% of patients, respectively. The Izbicki pain score decreased significantly; the median dropped from 47.5 to 4.4. The quality of life using SF-12 physical and mental component summary improved significantly; the medians increased from 41.7 to 93.8, and 47.5 to 86.7, respectively. Endocrine function remained stable. Exocrine insufficiency developed in most patients as a natural progression of chronic pancreatitis. Two patients had complications directly related to surgical procedures (6%). No early postoperative deaths occurred.

Conclusions
Extended Partington procedure for chronic pancreatitis results in excellent pain relief and quality of life improvement, with a low morbidity rate, and does not worsen pancreatic function. It should replace the original Partington procedure in treating painful chronic pancreatitis.
No effect of real-world universal face masking on post-intravitreal injection endophthalmitis rate at a single tertiary academic center
Authors: Haliyur Rachana , Sinha Alina K. , Andrews Chris A. , Musch David C. , Conrady Christopher D. , Zacks David N. , Huvard Michael J. 
Published: January 2024

Purpose:
To determine if universal masking during COVID-19 altered rate and outcomes of post-injection endophthalmitis (PIE).

Methods:
Retrospective, single-site, comparative cohort study. Eyes diagnosed with endophthalmitis within 4 weeks of intravitreal injection at the University of Michigan from 8/1/2012 to 11/15/2022 were identified. Cases were considered “masking” between 3/15/2020 and 11/15/2022. Endophthalmitis rate, visual acuity (VA), and microbial spectrum were investigated.

Results:
There were 20 PIE cases out of 72,194 injections (0.028%; 1 in 3571 injections) pre-masking and 10 of 38,962 with universal masking (0.026%; 1 in 3846 injections) (OR 0.9; 95% [CI]: 0.4-2.0). Referral from the community was unchanged with 32 cases referred pre-masking (0.35 cases/month) and 10 cases with masking (0.31 cases/month). Presenting mean logMAR VA with masking of all PIE cases trended worse (2.35±0.40) compared to pre-masking (2.09±0.48) (P=0.05) with light perception VA more common with masking (31.6% vs 10.9%, P=0.06). There was no delay in time from procedure to initial treatment (P=0.36), no difference in rate of initial treatment with tap and inject (T/I), and similar positive-culture rates (P=0.77) between cohorts. VA after 30 days follow-up was clinically unchanged (∼20/500 vs 20/400) (P=0.59).

Conclusions:
Universal masking had no effect on PIE rate nor rate of culture-positive cases. While presenting VA appeared worse with masking, this was not statistically significant and current treatment paradigms resulted in similar visual outcomes.
Development and evaluation of a neonatal nurse practitioner mentoring workshop
Authors: Moss Colleen Reilly 
Published: January 2024

ABSTRACT
New graduate neonatal nurse practitioners (NNPs) need more than an orientation; they need mentoring to facilitate successful role transition and enhance job satisfaction. A gap exists in the literature about mentoring participant training and launching of successful programs for NNPs. This article provides an overview of the development and evaluation of a nurse practitioner (NP) mentoring workshop before the start of a formalized mentoring program. Workshop participants attended a half-day education event with an emphasis on mentoring program expectations, mentor and mentee roles, and effective communication. After the workshop, participants completed an electronic survey to evaluate satisfaction with the teaching and areas for improvement. From January 2022 through January 2023, newly hired NPs paired with experienced NP mentors participated in this structured workshop. Twenty-eight participants in two cohorts evaluated the workshop to identify meaningful aspects of the presentations and areas for improvement. Participants reported high levels of satisfaction with the interactive components of the 4-hr workshop. An interactive mentoring workshop helps participants establish realistic expectations and mutual goals. Further study is needed to identify time- and cost-efficient strategies in the preparation of effective mentoring participants to enhance the quality of mentoring programs.
Transmastoid Surgery for Superior Canal Dehiscence: Prospective Longitudinal Objective and Patient-Reported Audiovestibular Outcomes
Authors: Eberhard Kristine Elisabeth , West Niels Cramer , Cayé-Thomasen Per 
Published: January 2024

Objective
We assess symptom control, reversal and stability of objective third-window indicators, and hearing and balance function after transmastoid superior canal dehiscence plugging. To do this, we combine patient self-assessment questionnaires with auditory and vestibular test data collected at a preoperative and multiple postoperative visits.

Study Design
Prospective cohort study.

Setting
Tertiary referral center.

Patients
Patients who underwent transmastoid plugging for superior canal dehiscence from 2012 to 2020.

Intervention(s)
Plugging of the superior semicircular canal using the transmastoid approach.

Main Outcome Measure(s)
Patients were evaluated preoperatively, 3-month postoperative, and at yearly follow-ups (up to 8 yr postoperative). Self-assessment questionnaires included Autophony Index, Dizziness Handicap Inventory, Tinnitus Handicap Inventory, and Hearing Handicap Inventory. Objective tests included audiometry, cervical vestibular evoked myogenic potential, ocular vestibular evoked myogenic potential, and video head impulse test.

Results
There was a statistically significant improvement in Autophony Index and Hearing Handicap Inventory total scores from the preoperative evaluation to 1 year postoperative. Dizziness Handicap Inventory and Tinnitus Handicap Inventory total scores also improved but statistically insignificant. Cervical and ocular vestibular evoked myogenic potential amplitudes and low-frequency air-bone gap showed statically significant reversal of the third-window effect preoperative versus 1 year postoperative. Video head impulse test of the superior semicircular canal revealed cases of pathological function preoperative with postoperative recovery. Results were stable over time.

Conclusions
Superior canal dehiscence repair resolves symptoms of autophony and improves hearing disability. Objective third-window indicators reverse and show long-term stability. Auditory and vestibular function is preserved postoperative, even superior semicircular canal function may be normal. Data suggest that surgical outcomes should not be evaluated until 1 year postoperative.
Cochlear Implantation in Sporadic Intralabyrinthine Schwannomas with Single-Sided Deafness: Implications for Binaural Hearing
Authors: West Niels , Sørensen Rikke Skovhøj , Kressner Abigail Anne , Bille Michael , Marozeau Jeremy , Cayé-Thomasen Per 
Published: January 2024

Background and Objective
Intralabyrinthine schwannomas (ILSs) may have detrimental effects on ipsilateral hearing, commonly leading to single-sided deafness (SSD). Cochlear implantation in patients with ILSs is an option to partly restore ipsilateral hearing; however, the available literature fails to account for the binaural hearing benefits of a cochlear implant (CI) for ILSs.

Methods
We prospectively evaluated SSD patients with sporadic ILS undergoing cochlear implantation with simultaneous tumor resection (n = 10) or with tumor observation (n = 1). Patients completed the Speech, Spatial and Qualities Questionnaire (SSQ12) and the Nijmegen Cochlear Implant Questionnaire (NCIQ) pre- and postoperatively, as well as the Bern Benefit in Single-Sided Deafness (BBSSD) questionnaire postoperatively. Patients were also tested postoperatively with and without their CI to measure the effect on localization ability and binaural summation, squelch, and head shadow.

Results
Evaluation was completed for nine and six patients (subjective and objective data, respectively). The CI significantly improved the speech reception threshold (SRT) in the head shadow condition where the target signal was presented to the CI side and the noise to the front (SCIN0). On the other hand, the SRTs in the colocated condition (S0N0) and the condition where the target signal was presented to the front and the noise to the CI side (S0NCI) were unaffected by the CI. The mean localization error decreased significantly from 102° to 61° (p = 0.0031) with the addition of a CI. The scores from SSQ12 demonstrated nonsignificant changes. For NCIQ, the self-esteem and the social interaction domains increased significantly but insignificantly for the remaining domains. The BBSSD responses ranged from +0.5 to +3.5 points.

Conclusion
After implantation, patients achieved significantly better scores across some of the patient-reported and objective parameters. In addition to reporting on a number of ILS cases where implantation was performed, the study is the first of its kind to document patient-reported and objective binaural hearing improvement after cochlear implantation in patients with ILS and, thereby, lends support to the active management of ILS.
Advancements in Preclinical Models of Pancreatic Cancer
Authors: Salu Philip , Reindl Katie M. 
Published: January 2024

Abstract
Pancreatic cancer remains one of the deadliest of all cancer types with a 5-year overall survival rate of just 12%. Preclinical models available for understanding the disease pathophysiology have evolved significantly in recent years. Traditionally, commercially available 2-dimensional cell lines were developed to investigate mechanisms underlying tumorigenesis, metastasis, and drug resistance. However, these cells grow as monolayer cultures that lack heterogeneity and do not effectively represent tumor biology. Developing patient-derived xenografts and genetically engineered mouse models led to increased cellular heterogeneity, molecular diversity, and tissues that histologically represent the original patient tumors. However, these models are relatively expensive and very timing consuming. More recently, the advancement of fast and inexpensive in vitro models that better mimic disease conditions in vivo are on the rise. Three-dimensional cultures like organoids and spheroids have gained popularity and are considered to recapitulate complex disease characteristics. In addition, computational genomics, transcriptomics, and metabolomic models are being developed to simulate pancreatic cancer progression and predict better treatment strategies. Herein, we review the challenges associated with pancreatic cancer research and available analytical models. We suggest that an integrated approach toward using these models may allow for developing new strategies for pancreatic cancer precision medicine.
Factors Impacting Maltreatment Evaluation and Reports to Child Protective Services in Pediatric Substance Exposures
Authors: Breeden Karli , Loiselle Claire , Hossain Jobayer , De Jong Allan R. , Deutsch Stephanie Anne 
Published: January 2024

Objectives
The objective of this study was to assess demographic, clinical, and psychosocial factors associated with pediatric substance exposures, describe the medical evaluation, and identify factors associated with social work (SW) and hospital-based child protection team (CPT) safety assessments and reports to child protective services (CPS).

Methods
We retrospectively reviewed charts of electronic medical records for children ages 0 to 72 months presenting for accidental ingestion evaluated May 1, 2015 to May 1, 2021 at a level 1 pediatric trauma center. Cases of environmental exposures, iatrogenic medication errors, dosing errors, and allergies/adverse reactions were excluded. Data were analyzed using descriptive statistics; χ2 and multivariable logistic regression analysis assessed factors associated with two primary outcomes of interest, SW/CPT assessment and CPS report.

Results
Among 773 total cases of substance exposures during the studied time frame, 27% were referred to SW/CPT for further safety assessments and 15.4% were reported to CPS. Being admitted to the hospital, prescription medication or recreational/illegal/illicit substance exposures, and increasing psychosocial risk factors were found to be significantly associated with referrals. Age, race, and insurance status were not found to be associated. Toxicology screening was performed in only 24.7% of cases. Of those eligible for further imaging per hospital protocol, skeletal surveys were obtained in 5.5% of cases and head imaging was obtained in 9% of cases.

Conclusions
There is significant variability in pediatric substance exposure assessment practices. Disparities based on demographic characteristics are uncommon. Perceived severity of condition, exposures involving recreational/illegal/illicit substances, and greater prevalence of family psychosocial adversities are associated with higher rates of SW/CPT assessment and CPS reports.
The predictors for the knee extension strength at 2 years after total knee arthroplasty using regression tree analysis
Authors: Kitamura Gakuto , Nankaku Manabu , Yuri Takuma , Kuriyama Shinichi , Nakamura Shinichiro , Nishitani Kohei , Ikeguchi Ryosuke , Matsuda Shuichi 
Published: January 2024

Abstract

Objective
To clarify the interactive combinations of clinical factors associated with knee extension strength (KES) 2 years after TKA.

Design
A retrospective cohort study was conducted on 264 patients who underwent TKA. KES was assessed preoperatively, 3 weeks, and 2 years after TKA. Physical functions were measured with 10 m walking test (10MWT), Timed-up and Go test (TUG), one-leg standing time, isometric knee flexion strength, knee joint stability, knee pain, femora-tibial angle, and passive knee extension and flexion angle before surgery as a baseline and 3 weeks after TKA as acute phase. Regression tree analysis was conducted to clarify the interactive combinations that accurately predict the KES 2 years after TKA.

Results
Operational side KES (> 1.00 Nm/kg) at acute phase was the primal predictor for the highest KES at 2 years after TKA. Acute phase TUG (≤ 10.13 seconds) and baseline 10MWT (≤ 11.72 seconds) was the second predictor. Acute phase non-operative side KES (> 0.90 Nm/kg) was also selected as the predictor.

Conclusion
This study demonstrated that KES or TUG in the acute phase and 10MWT before TKA are useful for estimating the KES after TKA. The results will help determine specific postoperative rehabilitation goals and training options.
Utility of Structured Oculomotor, Balance, and Exercise Testing in Civilian Adults with Mild Traumatic Brain Injury (mTBI)
Authors: DeGroot Andrew , Simons Mary U. , Huber Daniel L. , Leddy John , McCrea Michael A. , Johnson Blair D. , Nelson Lindsay D. 
Published: January 2024

Abstract

Purpose
Assessments of oculomotor, balance, and exercise function detect different responses to mild traumatic brain injury (mTBI) in sport-related mTBI. These assessments are understudied in the adult community mTBI population. We evaluated level 1 trauma center patients with non-sports related mTBI on oculomotor functioning (near point of convergence [NPC] and accommodation [NPA]), balance (Balance Error Scoring System [BESS]), and exercise tolerance (Buffalo Concussion Treadmill Test [BCTT]).

Methods
A prospective, cohort study of adults with mTBI (N = 36) were assessed at 1 week and (N = 26) 1 month post-mTBI using NPC, NPA, BESS, BCTT, and the Rivermead Post Concussion Symptoms Questionnaire [RPQ]. Prevalence of test impairment and association between performance and mTBI-related symptom burden (RPQ scores) were characterized.

Results
Participants demonstrated varying levels of impairment (e.g., 33.3% oculomotor, 44.1% balance, and 55.6% exercise impairment at 1 week). Participants displayed diverse impairment profiles across assessments. We observed medium-to-large correlations between poorer NPC and BCTT performance and greater mTBI symptom burden.

Conclusions
Clinical examinations of oculomotor function, balance, and exercise adopted from sport-related concussion assessments detect impairment in adult community members with mTBI. While findings warrant larger-scale replication, they imply that incorporating these simple, structured exams into the assessment of mTBI may facilitate more personalized management strategies.