bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη Axis
Authors: Wang Huifang , Li Yichen , Jiang Shuqi , Liu Nan , Zhou Qiuping , Li Qian , Chen Zhuo , Lin Yiyan , Chen Chunbo , Deng Yiyu 
Published: December 2023

BackgroundNeuroinflammation is a common feature of many neurological diseases, and remains crucial for disease progression and prognosis. Activation of microglia and astrocytes can lead to neuroinflammation. However, little is known about the role of lncRNA xist and miR-122-5p in the pathogenesis of sepsis-associated neuroinflammation (SAN). This study aims to investigate the role of lncRNA xist and miR-122-5p in the pathogenesis of SAN.MethodsLevels of miR-122-5p and proinflammatory mediators were detected in the cerebrospinal fluid (CSF) of patients with intracranial infection (ICI) by ELISA and qRT-PCR. miRNA expression in the periventricular white matter (PWM) in rats was analyzed by high-throughput sequencing. Levels of lncRNA xist, miR-122-5p and proinflammatory mediators in the PWM were measured using qRT-PCR and western blot. Bioinformatics analysis was used to predict the upstream and downstream of miR-122-5p. The interaction between miR-122-5p and its target protein was validated using luciferase reporter assay. BV2 and astrocytes were used to detect the expression of lncRNA xist, miR-122-5p.ResultsThe level of miR-122-5p was significantly decreased in the CSF of ICI patients, while the expression of IL-1β and TNF-α were significantly upregulated. Furthermore, it was found that the expression of IL-1β and TNF-α were negatively correlated with the level of miR-122-5p. A high-throughput sequencing analysis showed that miR-122-5p expression was downregulated with 1.5-fold changes in the PWM of CLP rats compared with sham group. Bioinformatics analysis found that lncRNA xist and PKCη were the upstream and downstream target genes of miR-122-5p, respectively. The identified lncRNA xist and PKCη were significantly increased in the PWM of CLP rats. Overexpression of miR-122-5p or knockdown of lncRNA xist could significantly downregulate the level of PKCη and proinflammatory mediators from activated microglia and astrocytes. Meanwhile, in vitro investigation showed that silencing lncRNA xist or PKCη or enhancing the expression of miR-122-5p could obviously inhibit the release of proinflammatory mediators in activated BV2 cells and astrocytes.ConclusionLncRNA xist could regulate microglia and astrocytes activation in the PWM of CLP rats via miR-122-5p/PKCη axis, further mediating sepsis associated neuroinflammation.
Cytokines profile in pure neural leprosy
Authors: Pitta Izabela Jardim R. , Angst Debora Bartzen Moraes , Pinheiro Roberta Olmo , Vieira Joyce Soares da Silva , Spitz Clarissa Neves , Andrade Ligia Rocha , Carvalho Larissa Bittencourt , Hacker Mariana Andrea , Sarno Euzenir Nunes , Jardim Marcia Rodrigues 
Published: December 2023

IntroductionPure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood.ObjectiveDescribe the cytokines profile in patients with PNL.Methods30 Patients diagnosed with PNL in the Souza Araujo Outpatient Clinic and with cytokines evaluated were selected. They were evaluated by neurologists and diagnosed after a nerve biopsy. Serum levels of IL-1 β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-ϒ, CXCL-10/IP-10 and TGF-β were evaluates at the moment of the diagnosis.ResultsNeural thickening was a common clinical finding in this groups of patients. Small and medium sensitive fibers signs and symptoms were present in 92% of the patients and motor involvement in 53%. 43% of patients presented neuropathic pain and no one had neuritis TGF-beta, IL-17, CCl-2 and IP-10. CCL-2 levels were associated with demyelinating patters and IP-10 and IL-1o were associated with axonal patterns at NCS.DiscussionPNL patients’ cytokine profile appears to be different of other clinical forms of leprosy, with the presence of cytokines described in both tuberculoid and lepromatous leprosy. High levels of CCl-2 may be related to the presence of silent neuritis as well as the presence of IL-10. PNL is unique a form of leprosy, therefore, understanding its immunological profiles essential to better understand the disease itself.
Transnasal humidified rapid-insufflation ventilator exchange compared with laryngeal mask airway for endoscopic thoracic sympathectomy: a randomized controlled trial
Authors: Lin Chunmei , Wang Dandan , Yan Yulu , Zhong Ruihan , Li Chaoyang , Zhang Jie 
Published: December 2023

BackgroundTransnasal humidified rapid-insufflation ventilator exchange (THRIVE) has the characteristics of operating easily and maintaining oxygenation and eliminating CO2, which makes it possible to be used in endoscopic thoracic sympathectomy (ETS). The application of THRIVE in ETS remains undefined. The purpose of this randomized controlled study is to assess the efficacy between THRIVE and laryngeal mask airway (LMA) for ETS.MethodsIn total, 34 patients from May 2022 to May 2023 in Huazhong University of Science and Technology Union Shenzhen Hospital undergoing ETS were randomly divided into a THRIVE group (n = 17) and an LMA group (n = 17). A serial arterial blood gas analysis was conducted during the perioperative period. The primary outcome was the arterial partial pressure of carbon dioxide (PaCO2) during the perioperative period. The secondary outcome was arterial partial pressure of oxygen (PaO2) during the perioperative period.ResultsThe mean (SD) highest PaCO2 in the THRIVE group and LMA group were 99.0 (9.0) mmHg and 51.7 (5.2) mmHg, respectively (p &lt; 0.001). The median (inter-quartile range) time to PaCO2 ≥ 60 mmHg in the THRIVE group was 26.0 min (23.2–28.8). The mean (SD) PaO2 was 268.8 (89.0) mmHg in the THRIVE group and 209.8 (55.8) mmHg in the LMA group during surgery (p = 0.027).ConclusionCO2 accumulation in the THRIVE group was higher than that of the LMA group during ETS, but THRIVE exhibited greater oxygenation capability compared to LMA. We preliminarily testified that THRIVE would be a feasible non-intubated ventilation technique during ETS under monitoring PaCO2.
The relaxation effect of autonomous sensory meridian response depends on personal preference
Authors: Sakurai Noriko , Nagasaka Kazuaki , Sasaki Kei , Yuguchi Yukina , Takahashi Shingo , Kasai Satoshi , Onishi Hideaki , Kodama Naoki 
Published: December 2023

BackgroundAutonomous sensory meridian response (ASMR) is a sensory response such as tingling and pleasantness from audiovisual stimuli. ASMR videos come in a wide variety of types, and personal preferences are biased. There are many reports of the effects os ASMR on sleep onset, anxiety relief, and other relaxation effects. However, prior task-oriented studies have used ASMR videos provided by the experimenter. We hypothesized that ASMR movies of a personal preference would show significantly increased activity in the nucleus accumbens, frontal cortex, and insular cortex, which are brain areas associated with relaxation. Therefore, the purpose of this study was to elucidate the neuroscientific basis for the relaxation effects of ASMR videos that match someone’s personal preferences.MethodsThis study included 30 healthy individuals aged ≥18 years. ASMR enthusiasts were included as the target population due to the need to have a clear preference for ASMR videos. A control video (1 type) and ASMR videos (20 types) were used as the stimulus tasks. Among the ASMR videos, those with high and low evaluation scores were considered liked and dislikedASMR videos, respectively. Functional magnetic resonance imaging was performed while the participants viewed a block design with a resting task in between. The data were analyzed using Statistical Parametric Mapping 12 to identify the areas activated by control, disliked, and liked ASMR videos.ResultsEmotion-related areas (the amygdala, frontal cortex, and insular cortex) not activated by control and unliked ASMR videos were activated only by liked ASMR videos.ConclusionThe amygdala, frontal cortex, and insular cortex may be involved in the limbic dopamine circuits of the amygdala and middle frontal gyrus and the autonomic balance of the left and right insular cortices. This suggests the potential of positive mood and its use as a treatment for patients with anxiety and depression. These results suggest that the use of ASMR videos to match individual preferences may induce relaxation and have beneficial effects on depression and other disorders, and also support the introduction of ASMR videos in mental health care.
Efficacy of mFOLFOX6 plus bevacizumab regimen in advanced colorectal cancer after deep hyperthermia: a single-center retrospective study
Authors: Han Guohu , Cui Lihua , Sun Changchun , Yu Lijiang , Liu Shenzha 
Published: December 2023

BackgroundThis study aimed to explore the clinical efficacy and safety of a modified FOLFOX6 (oxaliplatin + leucovorin + 5-fluorouracil) plus bevacizumab regimen after deep hyperthermia in advanced colorectal cancer.MethodsA total of 80 colorectal cancer patients treated at our hospital were selected as research subjects. According to the random number table method, patients were divided into a control group (mFOLFOX6 plus bevacizumab) and a combination group (mFOLFOX6 plus bevacizumab after deep hyperthermia treatment), with 40 patients in each group. After six cycles of treatment, the objective response rate (ORR), disease control rate (DCR), levels of serum tumor markers carcinoembryonic antigen (CEA), vascular epidermal growth factor (VEGF), Karnofsky performance status (KPS) scores, and the occurrence of adverse events were compared between the two groups.ResultsAfter six cycles of treatment, the ORR in the combination group was higher than that in the control group, but the difference was not statistically significant (P&gt;0.05). The DCR in the combination group was significantly higher than that in the control group (P&lt;0.05). The serum CEA levels in the control and combination groups after treatment were significantly lower than those before treatment, and the serum CEA and VEGF levels in the combination group were significantly lower than those in the control group (all P&lt;0.001). The KPS scores in both groups after treatment were higher than those before treatment, and the KPS scores in the combination group after treatment were significantly higher than those in the control group (all P&lt;0.001). The incidence of fatigue and pain in the combination group was significantly lower than that in the control group (P&lt;0.05).ConclusionmFOLFOX6 plus bevacizumab after deep hyperthermia is effective in advanced colorectal cancer patients, which can effectively improve their quality of life, and the adverse events are controllable and tolerable. A randomized or prospective trial will be required to further prove these data and explore its potentiality, especially if compared to conventional treatment.
Deep-learning-based deformable image registration of head CT and MRI scans
Authors: Ratke Alexander , Darsht Elena , Heinzelmann Feline , Kröninger Kevin , Timmermann Beate , Bäumer Christian 
Published: December 2023

This work is motivated by the lack of publications on the direct application of multimodal image registration with deep-learning techniques for the enhancement of treatment planning in particle therapy. An unsupervised workflow, which seeks to improve image alignment, was developed and evaluated for computed tomography and magnetic resonance imaging scans of the head. The scans of 39 paediatric patients with brain tumours were available. The focus of the two-step workflow, including preprocessing of the scans for normalisation, is deformable image registration (DIR) with a deep neural network, which generates deformation vector fields (DVFs). To obtain a suitable configuration of the network, parameter tuning is performed by varying its parameters, e.g., layer size, regularisation (λ) of the DVF and learning rate (α). Image similarity was determined with the Dice similarity coefficient, mDSC, using segmented images and the mutual-information metric, mMI. The performance of the deep-learning models was assessed with the inverse consistency, mIC, and the Jacobian determinant, mJD. Inverse consistency is obtained for mIC = 0 mm, while the determinant of a deformed image is expected to be unity. The deep-learning models passed both performance checks, indicated by the mean values m̄IC=(0.57±1.00)mm and m̄JD=(1.00±0.07). Models with λ ≥ 1 yielded higher mDSC values than models with lower λ values. A small-architecture model with α = 10–4 was found to be most suitable for DIR, as improvement in image similarity of up to 12% was obtained in terms of mMI. The direct application of deep-learning models produced registered images improving image alignment between scans of different modalities.
Mobile-Based Application Interventions to Enhance Cancer Control and Care in Low- and Middle-Income Countries: A Systematic Review
Authors: Donkor Andrew , Ayitey Jennifer Akyen , Adotey Prince Nyansah , Ofori Esther Oparebea , Kitson-Mills Doris , Vanderpuye Verna , Opoku Samuel Yaw , Luckett Tim , Agar Meera R. , Engel-Hills Penelope 
Published: December 2023

Objective: To identify and appraise mobile-based application (mAPP) interventions that have been used to support cancer control and care in low- and middle-income countries (LMICs).Methods: Four electronic databases were systematically searched for studies that reported primary research findings related to mAPP interventions applied in oncology settings in LMICs. A narrative synthesis was performed using the Mhealth Index and Navigation Database as an analytical framework.Results: Twenty studies reporting 18 cancer control and care mAPPs were included in this review. Among these mAPPs, ten focused on prevention, screening and early detection of cancer, five provided information to optimise supportive and palliative care, two provided support to assist treatment-shared decision-making and one covered information for follow-up and survivorship care.Conclusion: Cancer mAPP interventions are gradually gaining attention in LMICs as they provide unique resources for empowering and strengthening the role of people with cancer in their own care. To enhance cancer control, a focus on prevention and early detection is important; however, more mAPP interventions related to cancer treatment, follow-up and survivorship are also needed to enable more cost-effective cancer care.
Pengembangan Sistem Informasi Pengajuan ISBN di Perpustakaan Politeknik Caltex Riau
Authors: Qudsi Dini hidayatul , Zulvi Mutia Sari 
Published: December 2023

Pengajuan ISBN (International Standard Book Number) merupakan salah satu fasilitas yang disediakan Perpustakaan Politeknik Caltex Riau (PCR) kepada sivitas akademika untuk membantu sivitas akademika dalam pengurusan ISBN ke Perpustakaan Nasional. Selama ini, proses pengajuan ISBN Penerbit Politeknik Caltex Riau (PCR) memakan waktu yang cukup lama. Penulis melakukan komunikasi via email yang dikirimkan kepada staf perpustakaan, sehingga penulis maupun staf kesulitan dalam melihat status progres pengajuan ISBN. Oleh karena itu, dibangunlah sebuah sistem perpustakaan, yang dapat mengelola proses pengurusan ISBN Penerbit Politeknik Caltex. Pengembangan sistem dilakukan dengan menerapkan metodologi Rapid Application Development (RAD). Pengembangan sistem dengan metodologi RAD lebih sesuai diterapkan pada sistem berskala kecil, dan jangka pendek. Sistem yang dihasilkan telah diuji dengan menggunakan metode black box testing dan menyatakan bahwa fitur-fitur sistem 100% sudah berjalan sesuai dengan yang diharapkan.
Pareciera que no leyeron a Sun Tzu
Authors: Medina Andrés Javier , Ciolli Joaquín David , Maza Teodoro Ramón 
Published: December 2023

Hace 41 años, entre el 2 de abril y el 14 de junio del año 1982, tuvo lugar el Conflicto Armado del Atlántico Sur; por el cual se disputó la soberanía de los archipiélagos de las Islas Malvinas, Georgias del Sur y Sándwich del Sur. Los principales protagonistas y oponentes en el campo de batalla fueron la República Argentina y el Reino Unido de Gran Bretaña e Irlanda del Norte.
A tres meses de concluida la Guerra de Malvinas, el Gobierno argentino ordenó la conformación de una Comisión para el Análisis y la Evaluación de las Responsabilidades Políticas y Estratégico-militares en el Conflicto del Atlántico Sur (CAERCAS).
El análisis arrojó como resultado un trabajo conocido como Informe Rattenbach, el cual concluye crudamente en serias falencias cometidas por el Gobierno y la Conducción Superior de las Fuerzas Armadas de la República Argentina, las que llevarían a la declaración del cese de las hostilidades y a su consecuente derrota al final de la contienda, aquel 14 de junio de 1982. Pareciera que las autoridades argentinas que se desempeñaron durante el conflicto, según Rattenbach y haciendo un paralelismo, jamás hubieran leído a Sun Tzu.
ТЕХНОЛОГІЯ ПРОЄКТУВАННЯ КОНСАЛТИНГОВОЇ ДІЯЛЬНОСТІ В ЗАКЛАДІ ВИЩОЇ ОСВІТИ В УМОВАХ НЕВИЗНАЧЕНОСТІ
Authors: Драгунова Віра 
Published: December 2023

Актуальність оглядового дослідження зумовлена умовами невизначеності нашої держави, які сьогодні рухають економіку, науку, культуру, освіту, промисловість та зумовлюють розвиток освітнього консалтингу. Підкреслюється стрімке зростання консультаційних послуг, що зумовлює розвиток консалтингової діяльності, яка передує значним втратам спричиненими через допущення помилок керівниками при управлінській діяльності тощо. Наголошується на важливості управлінського консультування в сучасній освітній діяльності менеджера закладу вищої освіти, особливо в умовах глобальних викликів, таких як інтернаціоналізація, мобільність, демократизація, диверсифікація тощо. У статті підкреслюється важливість та необхідність осмислення ролі менеджера закладу вищої освіти в умовах невизначеності на тлі соціально-економічних криз, коли формується інноваційна культура управління закладом освіти. Розглянуто та розкрито сутність консалтингової діяльності в закладі вищої освіти. Здійснено науково-теоретичний аналіз проєктування консалтингової діяльності в закладі вищої освіти в умовах невизначеності, визначено основні вимоги їх упровадження. Охарактеризовано модель, яка упроваджуватиметься в управлінський процес саме за допомогою проєктування консалтингової діяльності, з продукуванням та впровадженням інноваційних змін, з урахуванням регіональної специфіки діяльності, зовнішніх та внутрішніх факторів. Розкрито технологію проєктування консалтингової діяльності в закладі вищої освіти в умовах невизначеності. Відображено поетапне впровадження складових частин технології на основі реалізації проєктної діяльності. У статті розглянуто труднощі та суперечності, притаманні становленню інформаційно-консультативного середовища закладу вищої освіти та розвитку консалтингової діяльності у галузі освіти.
Hubungan Kadar Fibronektin Serum dengan Tingkat Kesadaran Menurut Klasifikasi CT-Marshall pada Cedera Otak Sedang dan Berat Akibat Trauma
Authors: Mogi Diornald J. , Prasetyo Eko , Oley Maximillian C. , Tjungkagi Ferdinan , Manuhutu Yovanka N. 
Published: December 2023

Abstract: Traumatic brain injury (TBI) is the main cause of brain damage in the adolescent and productive age generations, and its incidence is increasing every year. To date, there is still no accurate biological marker for detection of traumatic brain damage or prognosis related to the brain damage. One of the promising biological markers for detection of brain damage is fibronectin. This study aimed to evaluate the relationship between level of serum fibronectin and level of consciousness based on CT-Marshall in TBI patients. This was an observational and analytical study with a cross-sectional design. Samples that met the study criteria were taken sequentially from the study hospital without differentiating exposure status (serum fibronectin levels) or outcome (CT-Marshall category). The regression test on level of serum fibronectin and level of consciousness based on the CT-Marshall category obtained significant result indicating that the higher the serum fibronectin level, the higher the patient's CT-Marshall category which meant the patient had a higher degree of severity and poor consciousness. In conclusion, there is a significant relationship between level of serum fibronectin and level of consciousness based on the CT-Marshall category in moderate and sever traumatic brain injury patients.
Keywords: traumatic brain injury; biological marker; serum fibronectin; CT-Marshall category

Abstrak: Cedera otak akibat trauma (COT) merupakan penyebab utama kerusakan otak pada generasi muda dan usia produktif dengan angka kejadian meningkat setiap tahunnya. Saat ini, belum terdapat penanda biologis yang akurat untuk mendeteksi kerusakan otak traumatik ataupun menilai prognosis terkait kerusakan otak traumatik. Salah satu penanda biologis yang cukup menarik perhatian ialah fibronektin. Penelitian ini bertujuan untuk mengevaluasi hubungan antara kadar fibronektin serum dengan tingkat kesadaran menurut klasifikasi CT-Marshall pada COT. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Sampel yang memenuhi kriteria penelitian diambil berurutan dari rumah sakit tempat penelitian tanpa membedakan status paparan (kadar fibronektin serum) atau luaran (kategori CT-Marshall). Hasil uji regresi pada variabel utama kadar fibronektin serum dengan kesadaran menggunakan kategori CT-Marshall mendapatkan hasil bermakna yaitu semakin tinggi kadar fibronektin serum, semakin tinggi pula kategori CT-Marshall pasien yang berarti pasien memiliki derajat keparahan dan kondisi kesadaran yang buruk. Simpulan penelitian ini ialah terdapat hubungan bermakna antara kadar fibronektin serum dan tingkat kesadaran menggunakan kategori CT-Marshall pada pasien cedera otak traumatic sedang dan berat.
Kata kunci: cedera otak akibat trauma; penanda biologis; fibronektin serum; kategori CT-Marshall
Efficiency improvement tools for the roadmap of development of the high-tech direction “Hydrogen Energy”
Authors: Emelyanov V. V. 
Published: December 2023

Aim. Development of scientifically substantiated tools to increase the efficiency of the roadmap for the development of the high-tech direction “Hydrogen Energy”.Objectives. To evaluate the conformity of the standard passport of the road map of the high-tech direction to the tasks of the development of the direction “Hydrogen Energy”; to analyze the influence of the features of the direction “Hydrogen Energy” on the requirements to the road map; to propose tools to take into account the features of the direction “Hydrogen Energy” in the road map.Methods. The research was conducted on the basis of a set of general scientific methods (system analysis, method of dialectical cognition, etc.).Results. The need for additional functionality and tools for the roadmap “Hydrogen Energy” is shown, as the direction implies the development of an ecosystem of products based on several interrelated and competing technologies. By analyzing the features of the Hydrogen Energy roadmap, five tools are proposed to improve efficiency and reduce risks.Conclusions. The implementation of the proposed five tools will improve efficiency and reduce risks for the Hydrogen Energy roadmap by considering the structure of the direction, technology readiness level, and resource constraints.