bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report
Authors: Fielding David , Dalley Andrew J. , Singh Mahendra , Nandakumar Lakshmy , Lakis Vanessa , Chittoory Haarika , Fairbairn David , Patch Ann-Marie , Kazakoff Stephen H. , Ferguson Kaltin , Bashirzadeh Farzad , Bint Michael , Pahoff Carl , Son Jung Hwa , Ryan Kimberley , Hodgson Alan , Sharma Sowmya , Pearson John V. , Waddell Nicola , Lakhani Sunil R. , Hartel Gunter , Simpson Peter T. , Nones Katia 
Published: October 2023

IntroductionTumour Mutation Burden (TMB) is a potential biomarker for immune cancer therapies. Here we investigated parameters that might affect TMB using duplicate cytology smears obtained from endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA)-sampled malignant lymph nodes.MethodsIndividual Diff-Quik cytology smears were prepared for each needle pass. DNA extracted from each smear underwent sequencing using large gene panel (TruSight Oncology 500 (TSO500 - Illumina)). TMB was estimated using the TSO500 Local App v. 2.0 (Illumina).ResultsTwenty patients had two or more Diff-Quik smears (total 45 smears) which passed sequencing quality control. Average smear TMB was 8.7 ± 5.0 mutations per megabase (Mb). Sixteen of the 20 patients had paired samples with minimal differences in TMB score (average difference 1.3 ± 0.85). Paired samples from 13 patients had concordant TMB (scores below or above a threshold of 10 mutations/Mb). Markedly discrepant TMB was observed in four cases, with an average difference of 11.3 ± 2.7 mutations/Mb. Factors affecting TMB calling included sample tumour content, the amount of DNA used in sequencing, and bone fide heterogeneity of node tumour between paired samples.ConclusionTMB assessment is feasible from EBUS-TBNA smears from a single needle pass. Repeated samples of a lymph node station have minimal variation in TMB in most cases. However, this novel data shows how tumour content and minor change in site of node sampling can impact TMB. Further study is needed on whether all node aspirates should be combined in 1 sample, or whether testing independent nodes using smears is needed.
The role of attention and health goals in nudging healthy food choice
Authors: Gillebaart Marleen , Blom Stephanie S. A. H. , Benjamins Jeroen S. , de Boer Femke , De Ridder Denise T. D. 
Published: October 2023

IntroductionNudging is a promising intervention technique that supports people in pursuing their healthy eating goals. Recent research suggests that, despite previous assumptions, disclosure of the presence of a nudge does not compromise nudge effectiveness. However, it is unknown whether attention to a nudge affects nudge effects. We assessed the role of attention systematically, by examining explicit and implicit attention to nudges, while also exploring healthy eating goals as a potential moderator.MethodsParticipants were assigned to a nudge (i.e., a shopping basket inlay with pictures of healthy items) or control condition (i.e., a shopping basket inlay with neutral pictures) and chose a snack in an experimental supermarket field study. Explicit and implicit attention (with a mobile eye-tracker) to nudges, healthiness of snack choice, and healthy eating goals were assessed.ResultsResults showed that attention to the nudge did not hamper the nudge’s effect. Furthermore, individuals with strong healthy eating goals made healthier food choices in the nudge condition. Individuals with weak to non-existent healthy eating goals were not influenced by the nudge.DiscussionFindings are in line with the viewpoint that nudging does not by definition work ‘in the dark’, and suggests that nudges support people in adhering to their healthy eating goal.
Malaria in pregnancy in India: a 50-year bird’s eye
Authors: Kojom Foko Loick Pradel , Singh Vineeta 
Published: October 2023

IntroductionIn 2021, India contributed for ~79% of malaria cases and ~ 83% of deaths in the South East Asia region. Here, we systematically and critically analyzed data published on malaria in pregnancy (MiP) in India.MethodsEpidemiological, clinical, parasitological, preventive and therapeutic aspects of MiP and its consequences on both mother and child were reviewed and critically analyzed. Knowledge gaps and solution ways are also presented and discussed. Several electronic databases including Google scholar, Google, PubMed, Scopus, Wiley Online library, the Malaria in Pregnancy Consortium library, the World Malaria Report, The WHO regional websites, andClinicalTrials.govwere used to identify articles dealing with MiP in India. The archives of local scientific associations/journals and website of national programs were also consulted.ResultsMalaria in pregnancy is mainly due toPlasmodium falciparum(Pf) andP. vivax(Pv), and on rare occasions toP. ovalespp. andP. malariaetoo. The overall prevalence of MiP is ~0.1–57.7% for peripheral malaria and ~ 0–29.3% for placental malaria. PeripheralPfinfection at antenatal care (ANC) visits decreased from ~13% in 1991 to ~7% in 1995–1996 in Madhya Pradesh, while placentalPfinfection at delivery unit slightly decreased from ~1.5% in 2006–2007 to ~1% in 2012–2015 in Jharkhand. In contrast, the prevalence of peripheralPvinfection at ANC increased from ~1% in 2006–2007 to ~5% in 2015 in Jharkhand, and from ~0.5% in 1984–1985 to ~1.5% in 2007–2008 in Chhattisgarh. Clinical presentation of MiP is diverse ranging from asymptomatic carriage of parasites to severe malaria, and associated with comorbidities and concurrent infections such as malnutrition, COVID-19, dengue, and cardiovascular disorders. Severe anemia, cerebral malaria, severe thrombocytopenia, and hypoglycemia are commonly seen in severe MiP, and are strongly associated with tragic consequences such as abortion and stillbirth. Congenital malaria is seen at prevalence of ~0–12.9%. Infected babies are generally small-for-gestational age, premature with low birthweight, and suffer mainly from anemia, thrombocytopenia, leucopenia and clinical jaundice. Main challenges and knowledge gaps to MiP control included diagnosis, relapsing malaria, mixedPlasmodiuminfection treatment, self-medication, low density infections and utility of artemisinin-based combination therapies.ConclusionAll taken together, the findings could be immensely helpful to control MiP in malaria endemic areas.
Epidemiology of neurocognitive disorders in adults from urban-marginalized areas: a door-to-door population-based study in Puente Piedra, Lima, Peru
Authors: Herrera-Perez Eder , Custodio Nilton , Diaz Monica , Montesinos Rosa , Chang Alexandra , Villafuerte Mirla , Lanata Serggio 
Published: October 2023

BackgroundIn Latin America (LA), the prevalence of dementia is expected to triple to 150 million people by 2050. The 2020 Lancet Commission report identified several modifiable dementia risk factors, yet few social and environmental factors, most relevant to vulnerable regions of LA, were highlighted in this report. We sought to assess the epidemiology of neurocognitive disorders (NCD) in Puente Piedra, one of the most socially and economically vulnerable districts of Lima, the capital of Peru.MethodologyThis was a cross-sectional door-to-door observational study that used two-stage household sampling. One young adult (30–59 years) and one older adult (&gt;60 years) per household were enrolled. We collected demographic, clinical, and neurocognitive data. Addenbrooke’s Cognitive Examination (young adults) and the RUDAS-PE (older adults) were used, classifying participants as cognitively normal, possible mild NCD, or possible major NCD.ResultsWe enrolled 247 participants (median age 46 years; 67% female). One-fourth had not completed secondary school and more than 50% completed only secondary school. Most participants were housewives (46%) and 21% did not have health insurance. The overall prevalence of possible NCD was 30% (25.6 and 41.8% among younger adults and older adults, respectively). Among younger adults, those ages 55–59 years more frequently had NCD (70%) compared to younger age ranges. Among older adults, only 3 subjects (4.5%) had major NCD.ConclusionWe found a high frequency of possible NCDs in a socially and economically vulnerable community in Lima, Peru, with younger adults showing levels of NCD higher than expected. Our findings support the need for health systems to incorporate cognitive screenings programs for NCD in younger ages. Future research on NCD would include younger populations, particularly in vulnerable communities.
Psychosocial impact of COVID-19 pandemic: experience of healthcare workers in Qatar
Authors: Al-Qudimat Ahmad R. , Singh Kalpana , Mustafa Emad , Nashwan Abdulqadir J. , Al-Zoubi Raed M. , Yassin Aksam , Aboumarzouk Omar M. , Al-Ansari Abdulla 
Published: October 2023

BackgroundThe COVID-19 pandemic has had a profound and global impact on healthcare systems worldwide, presenting unprecedented challenges for healthcare workers (HCWs) on the front. We aimed to evaluate the prevalence of anxiety and depression symptoms during the coronavirus pandemic among healthcare professionals in Qatar.MethodsA cross-sectional study where an electronic questionnaire containing demographics, and psychosocial questions were made on Google Docs and Microsoft Team, and were sent through email and WhatsApp to healthcare workers, including doctors, nurses, allied health and others working at Hamad Medical Corporation in Qatar, from June 1, 2021, to January 1st 2023. ANOVA, t-test and multiple linear regression were used to see the association between the psychological factors and sociodemographic variables using STATA version 17 software.ResultsA total of 829 participants were included in this study (response rate: 55%). The average age of the participants is 36.0 ± 7.1; 65.9% were males; 2.3% were doctors and 53% were nurses, 38.7% were allied healthcare professionals and 6% were others. Psychological, social effects, and workplace were shown to significantly related to their marital status, career, and hospital setting (p &lt; 0.01 for each). Similar to this, dealing with COVID-19 patients and their education level with the length of time working at the designated facility were all connected with the health professional safety score (p &lt; 0.05).ConclusionDuring the COVID-19 epidemic, healthcare workers in Qatar experienced a high incidence of negative psychosocial symptoms. To alleviate these outcomes, it would be useful to implement screening procedures for such symptoms and to devise preventive measures accordingly.
Deep skin diseases diagnostic system with Dual-channel Image and Extracted Text
Authors: Li Huanyu , Zhang Peng , Wei Zikun , Qian Tian , Tang Yiqi , Hu Kun , Huang Xianqiong , Xia Xinxin , Zhang Yishuang , Cheng Haixing , Yu Fubing , Zhang Wenjia , Dan Kena , Liu Xuan , Ye Shujun , He Guangqiao , Jiang Xia , Liu Liwei , Fan Yukun , Song Tingting , Zhou Guomin , Wang Ziyi , Zhang Daojun , Lv Junwei 
Published: October 2023

BackgroundDue to the lower reliability of laboratory tests, skin diseases are more suitable for diagnosis with AI models. There are limited AI dermatology diagnostic models combining images and text; few of these are for Asian populations, and few cover the most common types of diseases.MethodsLeveraging a dataset sourced from Asia comprising over 200,000 images and 220,000 medical records, we explored a deep learning-based system for Dual-channel images and extracted text for the diagnosis of skin diseases model DIET-AI to diagnose 31 skin diseases, which covers the majority of common skin diseases. From 1 September to 1 December 2021, we prospectively collected images from 6,043 cases and medical records from 15 hospitals in seven provinces in China. Then the performance of DIET-AI was compared with that of six doctors of different seniorities in the clinical dataset.ResultsThe average performance of DIET-AI in 31 diseases was not less than that of all the doctors of different seniorities. By comparing the area under the curve, sensitivity, and specificity, we demonstrate that the DIET-AI model is effective in clinical scenarios. In addition, medical records affect the performance of DIET-AI and physicians to varying degrees.ConclusionThis is the largest dermatological dataset for the Chinese demographic. For the first time, we built a Dual-channel image classification model on a non-cancer dermatitis dataset with both images and medical records and achieved comparable diagnostic performance to senior doctors about common skin diseases. It provides references for exploring the feasibility and performance evaluation of DIET-AI in clinical use afterward.
Swirling of Horizontal Skyrmions into Hopfions in Bulk Cubic Helimagnets
Authors: Leonov Andrey O. 
Published: October 2023

Magnetic hopfions are three-dimensional topological solitons embedded into a homogeneously magnetized background. The internal structure of hopfions is distinguished by the linked preimages—closed loops with a single orientation of the magnetization on the target space S2—and is thus characterized by the integer Hopf index QH. Alternatively, hopfions can be visualized as a result of the swirling of two-dimensional bimerons around the direction of an applied magnetic field. Since the bimeron consists of a circular core and an anti-skyrmion crescent, two hopfion varieties can be achieved with either bimeron constituent facing the hopfion interior. In bulk cubic helimagnets, however, the applied magnetic field leads to a spontaneous collapse of hopfions, i.e., the eigen-energy of hopfions has the minimum for zero hopfion radius R. Anti-hopfions with QH=−1, in this case, pass through the intermediate toron state with two-point defects. Here, we demonstrate that the competing cubic and exchange anisotropies inherent in cubic non-centrosymmetric magnets (e.g., in the Mott insulator Cu2OSeO3) as a third level of the hierarchy of energy scales following the exchange and Dzyaloshinskii–Moriya interactions, may shift the energy minimum into the region of finite hopfion radii.
A política de inovação de uma instituição de pesquisa
Authors: Martin Adriana Regina , Melo Karla Da Costa Cartaxo , Tenorio Luciana Castro , Costa Naiara Creão da , Marmentini Priscilla , Carmo Talita Souza , Cruz Tânia Cristina Da Silva , Oliveira Washington Luiz S. de 
Published: October 2023

O objetivo deste estudo foi compreender o processo de implementação da política de inovação de uma instituição de pesquisa, sob a ótica legal, após a publicação do novo Marco Legal de Ciência, Tecnologia e Inovação no Brasil. O trabalho apresenta as premissas, diretrizes e todo o arcabouço normativo interno, que está sendo preparado para subsidiar ações internas que possibilitem a atuação da instituição, dentro do ecossistema de inovação. Além disso, discorre sobre a perspectiva legal do cenário de inovação no Brasil e os avanços alcançados com a nova legislação em vigor.
ТЕРМІН ОКУПНОСТІ ГІБРИДНОЇ СОНЯЧНОЇ ЕЛЕКТРОСТАНЦІЇ, ДО СКЛАДУ ЯКОЇ ВХОДИТЬ УСТАНОВКА ЗБЕРІГАННЯ ЕЛЕКТРОЕНЕРГІЇ З РІЗНИМИ ТЕХНІЧНИМИ ПАРАМЕТРАМИ
Authors: Буратинський І. М. 
Published: October 2023

У статті описано сформовані режими спільної роботи сонячної електростанції та установки зберігання електроенергії, що забезпечують відпуск електричної енергії, виробленої на власних генеру-вальних електроустановках сонячної електростанції, безпосередньо в електроенергетичну систему, перенесення електричної енергії, в разі її надлишків при піковій інтенсивності сонячного випромінювання або при низькій ціні електричної енергії на ринку в періоди профіциту в енергосистемі, за допомогою заряджання та розряджання акумуляторних батарей, відбір додаткових обсягів електричної енергії з електроенергетичної системи для підвищення економічної ефективності використання доступної енергоємності акумуляторних батарей у періоди низької інтенсивності сонячного випромінювання. За результатами проведеної техніко-економічної оцінки визначено термін окупності інвестиційного проєкту гібридної сонячної електростанції, який, виходячи зі сформованих режимів спільної роботи сонячної електростанції та установки зберігання електроенергії й цінових умов купівлі-продажу електричної енергії на ринку, становить 7–10 років залежно від комерційної енергоємності акумуляторних батарей.
Spatiotemporal dynamics of a diffusive predator-prey model with delay and Allee effect in predator
Authors: Liu Fang , Du Yanfei 
Published: October 2023

<abstract><p>It has been shown that Allee effect can change predator-prey dynamics and impact species persistence. Allee effect in the prey population has been widely investigated. However, the study on the Allee effect in the predator population is rare. In this paper, we investigate the spatiotemporal dynamics of a diffusive predator-prey model with digestion delay and Allee effect in the predator population. The conditions of stability and instability induced by diffusion for the positive equilibrium are obtained. The effect of delay on the dynamics of system has three different cases:	(a)	the delay doesn't change the stability of the positive equilibrium, (b) destabilizes and stabilizes the positive equilibrium and induces stability switches, or (c) destabilizes the positive equilibrium and induces Hopf bifurcation, which is revealed (numerically) to be corresponding to high, intermediate or low level of Allee effect, respectively. To figure out the joint effect of delay and diffusion, we carry out Turing-Hopf bifurcation analysis and derive its normal form, from which we can obtain the classification of dynamics near Turing-Hopf bifurcation point. Complex spatiotemporal dynamical behaviors are found, including the coexistence of two stable spatially homogeneous or inhomogeneous periodic solutions and two stable spatially inhomogeneous quasi-periodic solutions. It deepens our understanding of the effects of Allee effect in the predator population and presents new phenomena induced be delay with spatial diffusion.</p></abstract>
Quand la tugtupite groenlandaise devient une pierre précieuse
Authors: Bailleul Pia 
Published: October 2023

Quand, en 2019, le gouvernement groenlandais promeut l’exploitation artisanale des gemmes, une polémique s’ouvre autour du statut de la tugtupite : cette pierre locale exploitée de longue date est-elle précieuse ou non ? Pour les trois instances en présence, les critères d’évaluation varient : en gemmologie il existe des normes industrielles, pour l’État une éthique, et pour le marché artisanal une pratique. Abordant la gemme et les autres formes de tugtupite comme des « matérialités » de la ressource (Richardson et Weszkalnys, 2014), cet article examine les caractéristiques industrielles et politiques de la gemme et analyse les effets sociaux de la promotion de cette pierre au Groenland. Il montre notamment comment l’usage de cette catégorie de la ressource est devenu un instrument de représentation de l’État.
Conter (raconter)/réciter/narrer
Authors: Combettes Bernard 
Published: October 2023

L’article étudie les trois familles de mots conter (raconter) et conte, réciter et récit, narrer et narration et montre que les verbes à l’exception de raconter qui, assez tôt remplace conter, sortent de l’usage courant, sont supplantés par des périphrases (faire le récit) ou comme réciter, subissent une forte restriction de sens. Ce sont les noms – conte, récit et narration – qui endossent la valeur « technique » qu’on leur connaît aujourd’hui et qui perdurent.
Analyse narrative et culturelle de Vendredi ou la vie sauvage de Michel Tournier
Authors: Petitjean André 
Published: October 2023

L’objet de cet article est de faire une analyse narrative et culturelle du roman de Michel Tournier, Vendredi ou la vie sauvage (1971). Il s’agit d’une une réécriture de Vendredi ou les limbes du Pacifique (1967) qui fait partie des centaines de reprises intertextuelles du roman de Daniel Defoe, Robinson Crusoé (1719). Dans une première partie, j’étudie l’organisation logique de l’intrigue sous la forme d’une combinaison de différentes séquences et d’une organisation chronotopique particulière. Pour ce faire, j’ai recours aux études textuelles, en particulier pour rendre compte de la temporalité et de la spatialité, composants indispensables de toute fiction. Je m’appuie aussi sur les travaux narratologiques pour montrer que M. Tournier respecte les lois du genre caractéristiques des robinsonnades bien qu’il les détourne en se livrant à une réécriture critique du roman originel. Dans les trois parties suivantes, j’adopte un point de vue plus culturel que narratif. C’est ainsi que je montre ensuite que Robinson, pour seul et éloigné qu’il est de son pays d’origine, est profondément civilisé au sens éliasien du terme et se sert de cette acculturation pour affronter la situation nouvelle dans laquelle il se trouve placé. Dans une autre partie, j’analyse les modalités – formes et contenus – de l’antagonisme culturel entre Robinson et Vendredi. Je le fais en m’appuyant en particulier sur la théorisation des rapports entre Nature et Culture que l’on doit à l’anthropologue Philippe Descola. Enfin, dans une dernière partie, je m’interroge sur les enjeux de ce conflit culturel exposé narrativement par M. Tournier. On voit que, tout comme le héros de D. Defoe, Robinson impose son modèle culturel à Vendredi dans un premier temps ; puis, il renonce à son ethnocentrisme culturel et s’assimile à Vendredi dans un second temps.
Quelle place pour le récit dans les pratiques enseignantes de production d’écrit au CP ?
Authors: Leclaire-Halté Anne , Gremmo Marie-José 
Published: October 2023

L’objectif de cet article est d’étudier dans quelle mesure le travail de production d’écrit, dans les pratiques des enseignants de CP, est lié au développement de compétences à écrire un récit. Après avoir expliqué la constitution du corpus, constitué de 8 classes issues de la recherche Lire-Écrire CP, nous proposons d’abord une analyse des pratiques d’écriture au CP en en pointant la variété. Dans un deuxième temps, nous regardons plus particulièrement les pratiques liées au récit, en nous concentrant sur les deux classes où de telles pratiques sont clairement attestées, et en relevant leurs points communs et leurs différences. Une troisième partie met en rapport les pratiques effectives de production d’écrit que nous avons relevées et l’épreuve d’évaluation, intitulée « Production de texte », qui a été mise au point dans la recherche LECP pour évaluer le niveau de compétence des élèves à la fin de l’année de CP. Cette troisième partie montre un hiatus entre les pratiques enseignantes et la façon dont les textes d’élèves ont été évalués, ce qui conduit à pointer la complexité d’une telle évaluation et, en général, de l’enseignement d’une compétence écrite de type récit au CP.
Simposio 4: Embarazo en adolescente y diabetes mellitus
Authors: Basualdo Natalia 
Published: October 2023

La adolescencia es un período complejo de interacción entre la pubertad, la madurez neurocognitiva y la transición del rol social de una persona. Según la Dirección de Estadísticas e Información en Salud (DEIS), en Argentina durante 2019, 69.803 adolescentes de entre 15 y 19 años y 1.938 niñas menores de 15 años tuvieron un bebé, lo cual representa el 11,5% de los nacimientos anuales en Argentina. Por su parte, el Sistema Informático Perinatal (SIP) indica que el 29% de las adolescentes tuvo un hijo/a por segunda o tercera vez antes de los 20 años. UNICEF revela que el 70% de estos embarazos es no intencional. Si se suma que la diabetes mellitus (DM) es la patología crónica de mayor prevalencia en el embarazo, el aumento del riesgo perinatal es exponencial.
En DM pregestacional es importante destacar que todas las mujeres en edad fértil deben tener un método anticonceptivo de larga duración, a excepción de quienes están con glucemias en objetivo, se les suspendieron las drogas de riesgo y desean embarazarse.