bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterising the Aboriginal and Torres Strait Islander patient journey after a serious road traffic injury and barriers to access to compensation: a protocol
Authors: Hossain Sadia , Moeller Holger , Sharpe Patrick , Campbell Marnie , Kimlin Rebecca , Porykali Bobby , Shannon Brett , Gray Jodi , Afzali Hossein , Harrison James E , Ivers Rebecca Q , Ryder Courtney 
Published: November 2023

IntroductionRoad safety has been a long-enduring policy concern in Australia, with significant financial burden of road trauma and evident socioeconomic disparities. Transport injuries disproportionately impact individuals in remote areas, those in lower socioeconomic situations, and Aboriginal and Torres Strait Islander populations. There is a lack of insight into transport injuries in Aboriginal and Torres Strait Islander communities, absence of Indigenous perspective in published research and limited utilisation of linked data assets to address the inequity. Aim 1 is to determine the breadth, cost and causal factors of serious injury from road traffic crashes in South Australia (SA) and New South Wales (NSW) with a focus on injury prevention. Aim 2 is to identify enablers and barriers to compensation schemes for Aboriginal and Torres Strait Islander patients in SA and NSW.Methods and analysisThis study will be guided by an Aboriginal and Torres Strait Islander Governance Group, applying Knowledge Interface Methodology and Indigenous research principles to ensure Indigenous Data Sovereignty and incorporation of informed perspectives. A mixed-method approach will be undertaken to explore study aims including using big data assets and mapping patient journey.ConclusionThe results of this study will provide valuable insights for the development of focused injury prevention strategies and policies tailored to Aboriginal and Torres Strait Islander communities. By addressing the specific needs and challenges faced by these communities, the study aims to enhance road safety outcomes and promote equitable access to healthcare and compensation for affected individuals and their families.
Non-coding CGG repeat expansion inLOC642361/NUTM2B-AS1is associated with a phenotype of oculopharyngodistal myopathy
Authors: Gu Xinyu , Yu Jiaxi , Jiao Kexin , Deng Jianwen , Xia Xingyu , Qiao Kai , Yue Dongyue , Gao Mingshi , Zhao Chongbo , Dong Jihong , Huang Gongchun , Shan Jingli , Yan Chuanzhu , Di Li , Da Yuwei , Zhu Wenhua , Xi Jianying , Wang Zhaoxia 
Published: November 2023

BackgroundOculopharyngodistal myopathy (OPDM) is a rare adult-onset neuromuscular disease, associated with CGG repeat expansions in the 5′ untranslated region ofLRP12,GIPC1,NOTCH2NLCandRILPL1. However, the genetic cause of a proportion of pathoclinically confirmed cases remains unknown.MethodsA total of 26 OPDM patients with unknown genetic cause(s) from 4 tertiary referral hospitals were included in this study. Clinical data and laboratory findings were collected. Muscle samples were observed by histological and immunofluorescent staining. Long-read sequencing was initially conducted in six patients with OPDM. Repeat-primed PCR was used to screen the CGG repeat expansions inLOC642361/NUTM2B-AS1in all 26 patients.ResultsWe identified CGG repeat expansion in the non-coding transcripts ofLOC642361/NUTM2B-AS1in another two unrelated Chinese cases with typical pathoclinical features of OPDM. The repeat expansion was more than 70 times in the patients but less than 40 times in the normal controls. Both patients showed no leucoencephalopathy but one showed mild cognitive impairment detected by Montreal Cognitive Assessment. Rimmed vacuoles and p62-positive intranuclear inclusions (INIs) were identified in muscle pathology, and colocalisation of CGG RNA foci with p62 was also found in the INIs of patient-derived fibroblasts.ConclusionsWe identified another two unrelated cases with CGG repeat expansion in the long non-coding RNA of theLOC642361/NUTM2B-AS1gene, presenting with a phenotype of OPDM. Our cases broadened the recognised phenotypic spectrum and pathogenesis in the disease associated with CGG repeat expansion inLOC642361/NUTM2B-AS1.
Intrathoracic plates versus extrathoracic plates: a comparison of postoperative pain in surgical stabilization of rib fracture technique
Authors: Tichenor Michael , Reparaz Laura B. , Watson Christopher , Reeves Jeremy , Prest Phillip , Fitzgerald Michael , Patel Neema , Tan Xiyan , Hessey Jacob 
Published: November 2023

BackgroundSurgical stabilization of rib fractures (SSRF) has been shown to improve outcomes, yet there is an absence of studies comparing SSRF techniques. An intrathoracic system that minimizes incision length has recently been developed and adopted by multiple institutions. We hypothesized that SSRF with an intrathoracic system plus intercostal nerve cryoneurolysis (IC) leads to improved pain control compared with an extrathoracic system plus IC.MethodsA single-center, retrospective chart review was performed comparing intrathoracic SSRF versus extrathoracic SSRF, and included patients undergoing SSRF from 2015 to 2021 at a level 1 trauma center. Patients who did not undergo intercostal nerve cryoablation were excluded. The primary outcome was opioid consumption based on morphine milligram equivalent (MME) consumption. We collected Rib score, Blunt Pulmonary Contusion 18 Score, number of rib fractures, number of ribs plated, and Injury Severity Score (ISS) to compare baseline characteristics of each group.ResultsA total of 112 patients were evaluated for study inclusion. Thirty-one patients were excluded due to missing outcomes data and/or lack of cryoablation. There was no difference in ISS or Rib Score between the intrathoracic (n=33) and extrathoracic (n=48) groups. At 7-day follow-up, the median MME requirement was significantly lower in the intrathoracic group (21.25) versus the extrathoracic group (46.20) (p=0.02).ConclusionIntrathoracic SSRF was associated with a lower postoperative MME consumption compared with extrathoracic SSRF. These data support the use of intrathoracic SSRF to improve pain control compared to extrathoracic SSRF.Level of evidenceIII.
Exploring tidal force effects and shadow constraints for Schwarzschild-like black hole in Starobinsky–Bel-Robinson gravity
Authors: Arora Dhruv , Molla Niyaz Uddin , Chaudhary Himanshu , Debnath Ujjal , Atamurotov Farruh , Mustafa G. 
Published: November 2023

AbstractThe current manuscript deals with the tidal force effects, geodesic deviation, and shadow constraints of the Schwarzschild-like black hole theorised in Starobinsky–Bel-Robinson gravity exhibiting M-theory compactification. In the current analysis, we explore the radial and angular tidal force effects on a radially in-falling particle by the central black hole, which is located in this spacetime. We also numerically solve the geodesic deviation equation and study the variation of the geodesic separation vector with the radial coordinate for two nearby geodesics using suitable initial conditions. All the obtained results are tested for Sag A* and M87* by constraining the value of the stringy gravity parameter $$\beta $$
β
using the shadow data from the event horizon telescope observations. All the results are compared with Schwarzschild black hole spacetime. In our study, we found that both the radial and angular tidal forces experienced by a particle switch their initial behaviour and turn compressive and stretching, respectively, before reaching the event horizon. The geodesic deviation shows an oscillating trend as well for the chosen initial condition. For the constrained value of $$\beta $$
β
, we see that the spacetime geometry generated by Sag A* and M87* is effectively same for both Schwarzschild and Starobinsky–Bel-Robinson black hole. Furthermore, we also calculated the angular diameter of the shadow in Starobinsky–Bel-Robinson black hole and compared with the Schwarzschild black hole. It is observed that the angular diameter of shadow for M87* and Sgr A* in Starobinsky–Bel-Robinson black hole is smaller than the Schwarzschild black hole. The calculated results satisfy the event horizon telescope observational constraints.
Low-Leakage Double-Body MOSFET: A Promising Circuit-Level Technique for Deep-Submicron Analog Integrated Circuit Design
Authors: Maryan Mohammad Moradinezhad , Azhari Seyed Javad 
Published: November 2023

Since the leakage currents are dramatically increasing while the MOS transistors scale down to deep-submicron processes, the [Formula: see text]–[Formula: see text] characteristic of the channel is varied unintentionally. As a result, the analog integrated circuit (IC) designs based on it (at above 100-nm technologies) will malfunction. In this paper, a novel low-leakage double-body MOSFET (LLDB-M), as a circuit-level scheme in answering to the need for the current-mode analog IC design in deep-submicron processes, is proposed. In this technique, the sub-threshold and gate-oxide tunneling leakage currents (as two major parts) are reduced via lowering the gate-source voltage and increasing the threshold voltage of the MOS transistor. An LLDB-M consists of two typical transistors — the first one is the main transistor and the latter implements the shift-voltage to reduce the gate-source voltage and floor of the channel leakage currents. The drain, gate, and body of the main transistor as well as the body and source of the second one, organize the terminals of an LLDB-M. The proposed LLDB-M transistors are replaced with large-leakage transistors in a translinear loop in the weak inversion region and then the commonly-used circuits such-as the current mirror, one-quadrant multiplier-divider (at both up-down and stack topologies), the true RMS-DC converter, and the log-domain low-pass-filter are designed. The effectiveness and performance of the proposed LLDB-M technique and circuits are evaluated using HSPICE software in 22-nm BSIM4 CMOS process and Cadence Virtuoso tool in 65-nm TSMC CMOS technology. Post-layout simulation results show that the proposed circuit-level method by considerably reducing leakage currents could ensure the effective function of the current-mode analog IC designs in deep-submicron technologies. Also, comprehensive simulations have been performed to prove the robustness and reliability of the proposed circuits against process, voltage and temperature (PVT) changes.
CAN THE PIRANI SCORE PREDICT THE NECESSITY OF ACHILLES TENOTOMY FOR IDIOPATHIC CLUBFOOT PATIENTS TREATED WITH THE PONSETI METHOD?
Authors: Al-Shamari Ahmed Latteef 
Published: November 2023

Background: Idiopathic clubfoot is one of the most common congenital problems affecting newborns. Several methods are used for grading its severity, of which Pirani score is the most reliable one. The Ponseti method of clubfoot management is effective, producing better results and fewer complications than traditional surgical methods. Methods: The study includes 27 clubfeet who were diagnosed with clubfoot and who were scored using Pirani score and were treated with the Ponseti method with possible Achilles tenotomy. Result: The study showed that the mean Pirani scores before treatment were significantly higher in the tenotomy than in the non-tenotomy group (3.54 vs. 2.23 for the total Pirani score, 2.25 vs. 1.69 for the midfoot Pirani score and 1.29 vs. 0.59 for the hindfoot Pirani score). The study proposes a “before treatment” cutoff point of 2.75 for the total Pirani score, 1.75 for the midfoot Pirani score and 1.25 for the hindfoot Pirani score, where a score above these cutoff points can predict the need for tenotomy. Conclusion: This study showed that the Pre-treatment Pirani score can help surgeons decide whether to do tenotomy or not in patients treated with the Ponseti method.
A PROSPECTIVE OBSERVATIONAL STUDY OF OUTCOME IN CHILDREN OF CLUB FOOT TREATED FOR EQUINUS CORRECTION WITH WIDE BORE NEEDLE TENOTOMY
Authors: Singh Amit , Choudhary Jeewan , Siwach Gaurav , Kumar Ashok , Bansal Mohit , Singh Nirottam 
Published: November 2023

Introduction: Congenital talipes equinovarus is an idiopathic and common congenital deformity. Clubfoot treatment includes series stretching, manipulation, and immobilization; and for the relapse and resistant cases, management includes soft tissue releases, osteotomy, and immobilization. Tenotomy of the tendo-Achilles is an essential step in the Ponseti treatment of congenital talipes equinovarus (CTEV). In this study, we did a wide bore needle tenotomy, a minimally invasive technique for the management of equinus deformity. Materials and Methods: The study included 50 patients with 73 idiopathic clubfeet treated with the Ponseti technique. Out of which, 58 feet were treated by a wide bore needle tenotomy with aseptic precautions. Results: Out of all 73 feet managed with the Ponseti technique, 58 feet equinus were treated with a wide bore needle tenotomy, and the rest of the 15 feet equinus were corrected with a cast. The mean age at presentation of all the patients was 4.44 months. Mean cast applied was 7.24, equinus correction in age more than 6 months was only tenotomy. Conclusion: The results of our study showed good correction of deformity with low expenditure and minimal surgical intervention. The percutaneous needle tenotomy procedure offers a reliable and effective procedure for correcting equinus in club foot deformity with less chances of infection and other complications. We found that correction of equinus with cast is more effective at an early age of presentation and with a low Pirani severity score.
A Bridge to Graduation: Post-Secondary Effects of an Alternative Pathway for Students Who Fail High School Exit Exams
Authors: Lincove Jane Arnold , Mata Catherine , Cortes Kalena E. 
Published: November 2023

Abstract
High school exit exams are meant to standardize the quality of public high schools and to ensure that students graduate with a set of basic skills and knowledge. Evidence suggests that a common perverse effect of exit exams is an increase in dropout for students who have difficulty passing tests, with a larger effect on minority students. To mitigate this, some states offer alternative, non-tested pathways to graduation for students who have failed their exit exams. This study investigates the post-secondary effects of an alternative high school graduation program. Compared with similar students who fail to complete high school, those students who take the alternative pathway have better post-secondary outcomes in both education and employment. Compared with similar students who retake exit exams to graduate, those who eventually graduate through an alternative project-based pathway have lower college enrollment, but similar employment outcomes.
Persian Garlands of Stars: Islamicate and Indic Astral Sciences in Seventeenth-Century North India
Authors: Arzoumanov Jean 
Published: November 2023

Abstract
This paper offers a study of Mullā Farīd and Mullā Ṭayyib, two astronomers active in several North Indian courts in the first half of the seventeenth century. The lives and works of these two brothers illustrate the central role of mathematical astronomy and astrology in the science of the time and its use by Indian Muslim nobility. They also document the familiarity of Indian Muslim scholars with Indic astrology and its practice in Muslim milieux. Mathematical astronomy was very much alive in seventeenth-century Mughal India, and Persian-writing scholars were commenting and revising the astronomical data and mathematics transmitted from the Maragha and Samarqand schools of astronomy. Their intellectual activities are also better understood in the context of the avid interest in occult sciences cultivated by early modern Persianate societies, and more particularly by the Mughal court. Mathematical astronomy was nurtured for the precise purpose of casting horoscopes and creating astrological almanacs. Astrological practices in North-Indian courts, including Delhi, the Mughal imperial capital, were evidently mixed and flavoured with elements from both Islamicate and Indic traditions. Knowledge was widely shared across languages and scientific interests went well beyond religious denominations. Crucially too, the exchange between the Persian and the Sanskrit scholastic worlds was sponsored by Mughal patrons and resulted in scientific translations from one language to the other.
A closer reading of Mullā Farīd and Mullā Ṭayyib’s Persian works allows us to see that besides their more classical astronomical works, the two brothers shared a common interest in Indic methods of prognostication, in particular muhūrtaśāstra, the science of electing an auspicious moment to perform a certain action. In this paper, we elucidate an intricate dossier on the “bust hours,” an ancient prognostication method popular with Islamicate astrologers. Identified by Islamicate scholars as coming ultimately from India, the source of many features of Islamicate astrology, these bust hours were reinterpreted on Indian soil by Mullā Farīd and Mullā Ṭayyib in light of their first-hand knowledge of muhūrtaśāstra. In this manner, these bust hours came back full circle to the original Indian prognostication practices.
Acetylcysteine increases sensitivity of ceftazidime-avibactam–resistant enterobacterales with different enzymatic resistance to ceftazidime-avibactam in vitro and in vivo
Authors: Huang Zeyu , Han Yijia , Zhang Xiaotuan , Sun Yao , Lin Yuzhan , Feng Luozhu , Zhou Tieli , Wang Zhongyong 
Published: November 2023

Abstract
Background
Ceftazidime-avibactam (CZA) improves treatment outcomes for infections caused by carbapenem-resistant organisms, but has led to serious bacterial resistance. Acetylcysteine (NAC) is an approved medication that protects the respiratory tract through antioxidant and anti-inflammatory effects.

Results
This study found that NAC combined with CZA effectively inhibits the growth of CZA-resistant clinical Enterobacterales strains. The CZA/NAC combination inhibits biofilm formation in vitro and decreases bacterial burden in a mouse thigh infection model. The combination is biocompatible and primarily increases cell membrane permeability to cause bacterial death.

Conclusions
These findings prove that the CZA/NAC combination has potential as a treatment for CZA-resistant Enterobacterales infections.
The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis
Authors: Zakrzewska-Placzek Monika , Golisz-Mocydlarz Anna , Krzyszton Michal , Piotrowska Justyna , Lichocka Malgorzata , Kufel Joanna 
Published: November 2023

Abstract
Background
NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas human hNOL12 is crucial for the separation of the large (LSU) and small (SSU) ribosome subunit rRNA precursors.

Results
In this study we demonstrate that plant AtNOL12 is also involved in rRNA biogenesis, specifically in the processing of the LSU rRNA precursor, 27S pre-rRNA. Importantly, the absence of AtNOL12 alters the expression of many ribosomal protein and ribosome biogenesis genes. These changes could potentially exacerbate rRNA biogenesis defects, or, conversely, they might stem from the disturbed ribosome assembly caused by delayed pre-rRNA processing. Moreover, exposure of the nol12 mutant to stress factors, including heat and pathogen Pseudomonas syringae, enhances the observed molecular phenotypes, linking pre-rRNA processing to stress response pathways. The aberrant rRNA processing, dependent on AtNOL12, could impact ribosome function, as suggested by improved mutant resistance to ribosome-targeting antibiotics.

Conclusion
Despite extensive studies, the pre-rRNA processing pathway in plants remains insufficiently characterized. Our investigation reveals the involvement of AtNOL12 in the maturation of rRNA precursors, correlating this process to stress response in Arabidopsis. These findings contribute to a more comprehensive understanding of plant ribosome biogenesis.
Comparison of seven comorbidity scores on four-month survival of lung cancer patients
Authors: Pluchart Hélène , Bailly Sébastien , Chanoine Sébastien , Moro-Sibilot Denis , Bedouch Pierrick , Toffart Anne-Claire 
Published: November 2023

Abstract
Background
The comorbidity burden has a negative impact on lung-cancer survival. Several comorbidity scores have been described and are currently used. The current challenge is to select the comorbidity score that best reflects their impact on survival. Here, we compared seven usable comorbidity scores (Charlson Comorbidity Index, Age adjusted Charlson Comorbidity Index, Charlson Comorbidity Index adapted to lung cancer, National Cancer Institute combined index, National Cancer Institute combined index adapted to lung cancer, Elixhauser score, and Elixhauser adapted to lung cancer) with coded administrative data according to the tenth revision of the International Statistical Classification of Diseases and Related Health Problems to select the best prognostic index for predicting four-month survival.

Materials and methods
This cohort included every patient with a diagnosis of lung cancer hospitalized for the first time in the thoracic oncology unit of our institution between 2011 and 2015. The seven scores were calculated and used in a Cox regression method to model their association with four-month survival. Then, parameters to compare the relative goodness-of-fit among different models (Akaike Information Criteria, Bayesian Information Criteria), and discrimination parameters (the C-statistic and Harrell’s c-statistic) were calculated. A sensitivity analysis of these parameters was finally performed using a bootstrap method based on 1,000 samples.

Results
In total, 633 patients were included. Male sex, histological type, metastatic status, CCI, CCI-lung, Elixhauser score, and Elixhauser-lung were associated with poorer four-month survival. The Elixhauser score had the lowest AIC and BIC and the highest c-statistic and Harrell’s c-statistic. These results were confirmed in the sensitivity analysis, in which these discrimination parameters for the Elixhauser score were significantly different from the other scores.

Conclusions
Based on this cohort, the Elixhauser score is the best prognostic comorbidity score for predicting four-month survival for hospitalized lung cancer patients.