bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged Hypokalemia Following Metyrapone Treatment for Primary Bilateral Macronodular Adrenal Cortical Disease
Authors: Kidawara Yonekazu , Kakutani-Hatayama Miki , Fukuoka Hidenori , Koyama Hidenori 
Published: February 2024

Abstract
Surgical treatment is generally the standard therapeutic regimen used for primary bilateral macronodular adrenal cortical disease (PBMACD). However, in cases for which surgery is difficult or in which there is mild cortisol hypersecretion, metyrapone treatment can be selected. Although hypokalemia has been occasionally noted following metyrapone administration for Cushing syndrome associated with an adrenal adenoma, all such cases have been reported to be transient. Hypokalemia induced by metyrapone treatment is thought to occur due to excessive suppression of cortisol secretion, resulting in overproduction of adrenocorticotropic hormone from the pituitary gland, ultimately leading to excessive production of 11-deoxycorticosterone (DOC) in the adrenal cortex. A 52-year-old man diagnosed with PBMACD and started on metyrapone treatment subsequently presented with persistent hypokalemia. Interestingly, following initiation of metyrapone, blood test findings indicated marginal changes in serum cortisol, adrenocorticotropic hormone, and dehydroepiandrosterone sulfate levels, even when DOC levels were already markedly elevated. In addition to the effects of metyrapone, the present findings suggest a unique DOC synthesis regulatory mechanism involved in the pathogenesis of PBMACD.
Safety, Accuracy, and Efficacy of Robot-Assisted Stereo Electroencephalography in Children of Different Ages
Authors: Lu Rongrong , Wang Min , Zhang Yi , Li Hao , Zhou Yuanfeng , Wang Yi , Zhao Rui 
Published: February 2024

BACKGROUND AND OBJECTIVES:
Aimed to investigate the safety, accuracy, and efficacy of stereo electroencephalography (SEEG) in children of various ages, with particular emphasis on those younger than 3 years. There is limited guidance regarding whether SEEG can conducted on very young children.

METHODS:
This retrospective study was conducted between July 2018 and August 2022. It involved 88 patients who underwent 99 robot-assisted SEEG procedures at our center. The patients were categorized into 3 groups based on their age at the time of the robot-assisted SEEG procedures: group 1 (3 years and younger, n = 28), group 2 (age 3-6 years, n = 27), and group 3 (older than 6 years, n = 44). Clinical data, SEEG demographics, complications, and seizure outcomes were analyzed.

RESULTS:
A total of 675 electrodes were implanted, with an average of 6.82 ± 3.47 (2.00-16.00) electrodes per patient (P = .052). The average target point error for the 675 electrodes was 1.93 ± 1.11 mm, and the average entry point error was 1.30 ± 0.97 mm (P = .536 and P = .549, respectively). The overall percentage of complications was 6.06% (P = .879). No severe or long-term neurologic impairment was observed. Of the total 99 procedures included in this study, 78 were admitted for epilepsy surgery for the first time, while 9 patients were treated twice and 1 patient was treated 3 times. There were 21 radiofrequency thermocoagulation and 78 second-stage resective procedures performed after SEEG. There was no statistically significant difference in Engel class I outcomes among the patients who underwent SEEG in the 3 age groups (P = .621).

CONCLUSION:
Robot-assisted SEEG were demonstrated to be safe, accurate, and efficient across different age groups of children. This technique is suitable for children younger than 3 years who have indications for SEEG placement.
Counting Nemo: anemonefish Amphiprion ocellaris identify species by number of white bars
Authors: Hayashi Kina , Locke Noah J. M. , Laudet Vincent 
Published: February 2024

ABSTRACT
The brilliant colors of coral reef fish have received much research attention. This is well exemplified by anemonefish, which have distinct white bar patterns and inhabit host anemones and defend them as a territory. The 28 described species have between 0 and 3 white bars present, which has been suggested to be important for species recognition. In the present study, we found that Amphiprion ocellaris (a species that displays three white bars) hatched and reared in aquaria, when faced with an intruder fish, attacked their own species more frequently than other species of intruding anemonefish. Additionally, we explicitly tested whether this species could distinguish models with different numbers of bars. For this, 120 individuals of A. ocellaris were presented with four different models (no bars, and 1, 2 and 3 bars) and we compared whether the frequency of aggressive behavior towards the model differed according to the number of bars. The frequency of aggressive behavior toward the 3-bar model was the same as against living A. ocellaris, and was higher than towards any of the other models. We conclude that A. ocellaris use the number of white bars as a cue to identify and attack only competitors that might use the same host. We considered this as an important behavior for efficient host defense.
Reoperation risk of periprosthetic fracture after primary total hip arthroplasty using a collared cementless or a taper-slip cemented stem
Authors: Lynch Wong Matthew , Robinson Mark , Bryce Leeann , Cassidy Roslyn , Lamb Jonathan N. , Diamond Owen , Beverland David 
Published: February 2024

AimsThe aim of this study was to determine both the incidence of, and the reoperation rate for, postoperative periprosthetic femoral fracture (POPFF) after total hip arthroplasty (THA) with either a collared cementless (CC) femoral component or a cemented polished taper-slip (PTS) femoral component.MethodsWe performed a retrospective review of a consecutive series of 11,018 THAs over a ten-year period. All POPFFs were identified using regional radiograph archiving and electronic care systems.ResultsA total of 11,018 THAs were implanted: 4,952 CC femoral components and 6,066 cemented PTS femoral components. Between groups, age, sex, and BMI did not differ. Overall, 91 patients (0.8%) sustained a POPFF. For all patients with a POPFF, 16.5% (15/91) were managed conservatively, 67.0% (61/91) underwent open reduction and internal fixation (ORIF), and 16.5% (15/91) underwent revision. The CC group had a lower POPFF rate compared to the PTS group (0.7% (36/4,952) vs 0.9% (55/6,066); p = 0.345). Fewer POPFFs in the CC group required surgery (0.4% (22/4,952) vs 0.9% (54/6,066); p = 0.005). Fewer POPFFs required surgery in males with a CC than males with a PTS (0.3% (7/2,121) vs 1.3% (36/2,674); p < 0.001).ConclusionMale patients with a PTS femoral component were five times more likely to have a reoperation for POPFF. Female patients had the same incidence of reoperation with either component type. Of those having a reoperation, 80.3% (61/76) had an ORIF, which could greatly mask the size of this problem in many registries.Cite this article: Bone Joint J 2024;106-B(2):144–150.
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway
Authors: Yao Chen , Sun Jie , Luo Wanxin , Chen Hao , Chen Tianhao , Chen Cao , Zhang Bo , Zhang Yafeng 
Published: February 2024

AimsTo investigate the effects of senescent osteocytes on bone homeostasis in the progress of age-related osteoporosis and explore the underlying mechanism.MethodsIn a series of in vitro experiments, we used tert-Butyl hydroperoxide (TBHP) to induce senescence of MLO-Y4 cells successfully, and collected conditioned medium (CM) and senescent MLO-Y4 cell-derived exosomes, which were then applied to MC3T3-E1 cells, separately, to evaluate their effects on osteogenic differentiation. Furthermore, we identified differentially expressed microRNAs (miRNAs) between exosomes from senescent and normal MLO-Y4 cells by high-throughput RNA sequencing. Based on the key miRNAs that were discovered, the underlying mechanism by which senescent osteocytes regulate osteogenic differentiation was explored. Lastly, in the in vivo experiments, the effects of senescent MLO-Y4 cell-derived exosomes on age-related bone loss were evaluated in male SAMP6 mice, which excluded the effects of oestrogen, and the underlying mechanism was confirmed.ResultsThe CM and exosomes collected from senescent MLO-Y4 cells inhibited osteogenic differentiation of MC3T3-E1 cells. RNA sequencing detected significantly lower expression of miR-494-3p in senescent MLO-Y4 cell-derived exosomes compared with normal exosomes. The upregulation of exosomal miR-494-3p by miRNA mimics attenuated the effects of senescent MLO-Y4 cell-derived exosomes on osteogenic differentiation. Luciferase reporter assay demonstrated that miR-494-3p targeted phosphatase and tensin homolog (PTEN), which is a negative regulator of the phosphoinositide 3-kinase (PI3K)/AKT pathway. Overexpression of PTEN or inhibition of the PI3K/AKT pathway blocked the functions of exosomal miR-494-3p. In SAMP6 mice, senescent MLO-Y4 cell-derived exosomes accelerated bone loss, which was rescued by upregulation of exosomal miR-494-3p.ConclusionReduced expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenic differentiation and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.Cite this article: Bone Joint Res 2024;13(2):52–65.
Investigation of the Role of Shear Deflection in the Flexural Performance of Structural Insulated Panels
Authors: Shmulsky Rubin , Senalik Christopher Adam , Khademibami Laya , Mohammadabadi Mostafa , Seale Roy Daniel , Williamson Thomas , Ross Robert J. 
Published: February 2024

Abstract
As a material used in building construction, structural insulated panels (SIPs) deflect under flexural loading and creep over time. This work examines the deflection behavior of full-scale SIPs that were tested in bending. Approximately half of the matched specimens were tested after production and the other half were tested after a 90-day creep test. Of primary interest was the deflection behavior of the SIPs under load. After testing, the deflection was apportioned between the bending stiffness of the oriented strand board (OSB) and the shear modulus of the foam. Results indicated that when the known OSB modulus of elasticity values of 664,000 psi and 931,000 psi were considered among the different SIP thickness and treatments (with and without creep testing), the shear-based deflection from the foam ranged from 44 to 73 percent of the overall deflection. The calculated foam modulus of rigidity decreased slightly but significantly after creep testing. Also, the shear-based foam deflection increased slightly but significantly after creep testing.
Applying a cost-based pricing model for innovative cancer treatments subject to indication expansion: A case study for pembrolizumab and daratumumab
Authors: Heine R. J. S. D. , Thielen F. W. , Mathijssen R. H. J. , van Leeuwen R. W. F. , Franken M. G. , Uyl-de Groot C. A. 
Published: February 2024

Background
Expanding the indication of already approved immuno-oncology drugs presents treatment opportunities for patients but also strains healthcare systems. Cost-based pricing models are discussed as a possibility for cost containment. This study focuses on two drugs, pembrolizumab (Keytruda) and daratumumab (Darzalex), to explore the potential effect of indication broadening on the estimated price when using the cost-based pricing (CBP) model proposed by Uyl-de Groot and Löwenberg (2018).

Methods
The model was used to calculate cumulative yearly prices, cumulative prices per indication, and non-cumulative indication-based prices using inputs such as research and development (R&D) costs, manufacturing costs, eligible patient population, and a profit margin. A deterministic stepwise analysis and scenario analysis were conducted to examine how sensitive the estimated price is to the different input assumptions.

Results
The yearly cumulative cost-based prices (CBPs) ranged from €52 to €885 for pembrolizumab per vial and €823 to €31,941 for daratumumab per vial. Prices were higher in initial years or indications due to smaller patient populations, decreased over time or after additional indications. Sensitivity analysis showed that the number of eligible patients had the most significant impact on the estimated price. In the scenario analysis the profit margin contributed most to a higher CBPs for both drugs. Lower estimates resulted from assumed lower R&D costs.

Discussion
The estimated CBPs are consistently lower than Dutch list prices for pembrolizumab (€2,861), mainly resulting from larger patient populations in registered indications. However, daratumumab’s list prices fall within the range of modeled CBPs depending on the year or indication (€4,766). Both CBPs decrease over time or with additional indications. The number of eligible patients and initial R&D costs have the most significant influence on the CBPs. These findings contribute to the ongoing discussions on pharmaceutical pricing, especially concerning cancer drugs with expanding indications.
Cost-effectiveness of abobotulinumtoxinA plus best supportive care compared with best supportive care alone for early treatment of adult lower limb spasticity following an acute event
Authors: Moore Peter , Danchenko Natalya , Weidlich Diana , Tijerina Alejandra Rodarte 
Published: February 2024

Objectives
Spasticity is an incurable chronic condition, and patients with spasticity frequently experience symptoms such as muscle stiffness, restricted mobility, fatigue, spasms, and pain. The study objective was to assess the cost-effectiveness of abobotulinumtoxinA plus best supportive care compared with best supportive care alone for the early treatment of adult lower limb spasticity following an acute event (e.g. stroke or traumatic brain injury), from an Australian payer perspective.

Methods
Using clinical data from published pivotal trials, an economic model based on a Markov model was developed to capture changes in treatment costs, healthcare resource use costs, functional outcomes, and health-related quality of life over a lifetime horizon. Scenario analyses and a probabilistic sensitivity analysis were conducted to explore the uncertainty in the model parameters and assumptions used in the base case.

Results
AbobotulinumtoxinA plus best supportive care was cost-effective versus best supportive care, yielding an incremental cost-effectiveness ratio of $35,721 per quality-adjusted life year gained. Sensitivity analyses confirm the robustness of the base case, with most results remaining below the commonly acceptable cost-effectiveness willingness-to-pay threshold of $75,000 per quality-adjusted life year for cost-effectiveness in Australia. Inputs and assumptions that produced the top four highest incremental cost-effectiveness ratios include the application of different health resource utilisation source, short time horizon, unweighted regression analyses to determine regression probabilities, and no stopping rule. AbobotulinumtoxinA plus best supportive care has a 74% probability of being cost-effective compared with best supportive care alone at the willingness to pay threshold.

Conclusion
AbobotulinumtoxinA plus best supportive care treatment is cost-effective in Australia for the management of adult lower limb spasticity in patients treated within 2 years of an acute event.
Cost-effectiveness analysis of olaparib maintenance therapy for BRCA mutation ovarian cancer in the public sector in Malaysia
Authors: Yong Chee Meng , Yehgambaram Prathepamalar A. P. , Lee Shaun Wen Huey 
Published: February 2024

Introduction
Ovarian cancer is one of the most common cancer among women in Malaysia. Patients with ovarian cancer are often diagnosed at an advanced stage. Despite initial response to surgery and chemotherapy, most patients will experience a relapse. Olaparib has been reported have promising effects among BRCA mutated ovarian cancer patients. This study aimed to evaluate the cost–effectiveness of olaparib as a maintenance therapy for BRCA ovarian cancer in Malaysia.

Methods
We developed a four-state partitioned survival model which compared treatment with olaparib versus routine surveillance (RS) from a Malaysian healthcare perspective. Mature overall survival (OS) data from the SOLO-1 study were used and extrapolated using parametric models. Medication costs and healthcare resource usage costs were derived from local inputs and publications. Deterministic and probabilistic sensitivity analyses (PSA) were performed to explore uncertainties.

Results
In Malaysia, treating patients with olaparib was found to be more costly compared to RS, with an incremental cost of RM149,858 (USD 33,213). Patients treated with olaparib increased life years by 3.05 years and increased quality adjusted life years (QALY) by 2.76 (9.45 years vs 6.40 years; 7.62 vs 4.86 QALY). This translated to an incremental cost-effectiveness ratio (ICER) of RM 49,159 (USD10,895) per life year gained and RM54,357 (USD 12,047) per QALY gained, respectively. ICERs were most sensitive to time horizon of treatment, discount rate for outcomes, cost of treatment and health state costs, but was above the RM53,770/QALY threshold.

Conclusion
The use of olaparib is currently not a cost-effective strategy compared to routine surveillance based upon the current price in Malaysia for people with ovarian cancer with BRCA mutation, despite the improvement in overall survival.
Training of Future Psychologists: Providing Sustainable Rehabilitation Services to War Victims
Authors: Vasylenko Olena , Komar Taisiia , Pavlyuk Yevgen , Beregova Natalia , Dzhyhun Liudmyla , Ihumnova Olha , Havrylkevych Viacheslav 
Published: February 2024

The paper examines the problem of training future psychologists to provide rehabilitation services to war victims. It has been found that the psychological rehabilitation of war victims involves the work of psychologists to accelerate their psychological adaptation and prevent psychological complications that provoke the results of mental traumas associated with the provision of leaving home, work, usual comfortable life, etc. Therefore, psychologists must be ready to work with such persons and have a high level of professional competence. All this ensures effective professional training of future psychologists in institutions of higher education and the development of components of their readiness to provide rehabilitation services to war victims. We have found that these readiness components include: motivational, cognitive, operational and personal. The results of the diagnosis of the readiness components of psychology students to provide rehabilitation services to war victims have shown that, in addition to the personal component of readiness, all other components are developed at a sufficient level and this is due to the need to develop measures that are able to contribute to improving the level of training of future psychologists for psychological rehabilitation activities.
Key words: psychology students; psychological rehabilitation; war victims; readiness for professional activity
Outcomes of Serum Food-Specific Immunoglobulin G4 to Guide Elimination Diet in Patients With Eosinophilic Esophagitis
Authors: Lim Amanda Huoy Wen , Ngoi Benjamin , Perkins Griffith B. , Wong Stephanie , Whitelock Gail , Hurtado Plinio , Ruszkiewicz Andrew , Le Thanh-Thao Adriana , Hissaria Pravin , Nguyen Nam Quoc 
Published: February 2024

INTRODUCTION:
Eosinophilic esophagitis (EoE) is associated with atopy; however, recent studies have identified an association with food-specific immunoglobulin G4 (FS-IgG4) rather than immunoglobulin E antibodies. This study aimed to evaluate the role of serum FS-IgG4 in guiding an elimination diet and its outcomes.

METHODS:
Patients with and without EoE were enrolled in a prospective, controlled, single tertiary center trial. Serum FS-IgG4 titers, esophageal eosinophil counts, and dysphagia symptom questionnaire scores were assessed, and participants with elevated FS-IgG4 (ImmunoCAP, cutoff of 10 mgA/L) commenced 6-week targeted elimination diet. Repeat serum FS-IgG4 and endoscopic and histologic examination were performed at 6-week follow-up.

RESULTS:
Twenty-two patients with active EoE and 13 controls were recruited. Serum FS-IgG4 to milk, wheat, soy, eggs, and nuts was significantly higher in EoE (P = 0.0002, P = 0.002, P = 0.003, P = 0.012, and P < 0.001, respectively). Elevated serum FS-IgG4 to 1 or more food groups (median 2) was identified in 21/22 (95.4%) patients with EoE; 20/21 underwent 6-week dietary elimination. Median reductions in dysphagia symptom questionnaire score and EoE endoscopic reference score after elimination were 8 (P = 0.0007) and 1 (P = 0.002), respectively. Nine (45%) patients had histological remission (<15 eosinophils per high-power field). Fall in median esophageal eosinophil count was not statistically significant (50 vs 23; P = 0.068). Serum FS-IgG4 did not decline by 6-week follow-up.

DISCUSSION:
Serum FS-IgG4 to milk, wheat, soy, egg, and nuts was present at higher levels in EoE, with targeted elimination resulting in 45% histologic remission rate. Serum FS-IgG4 has potential as a noninvasive biomarker in EoE. When successful, FS-IgG4–led elimination diet can negate need for medications and be viewed more favorably by patients because of its smaller endoscopic burden compared with empirical elimination diets.
Mediators of the relationship between perceived social loafing and team performance among university student teams
Authors: Hang Pham Thu 
Published: February 2024

Abstract: Perceived social loafing has been found to be negatively related to team performance. However, far too little attention has been paid to the underlying mechanism of this association. Thepurpose of the present study is to investigate not only the direct relationship between perceived social loafing and team performance but also the indirect relationship between these two variables viamediating roles of the sucker effect/social compensation and social loafer’s continuous social loafing. A questionnaire survey was conducted with 360 students of a public university in Vietnam in 2021. The current study confirmed the previous finding that perceived social loafing could negatively influence team performance. The most striking result to emerge from the data was that the sucker effect had no correlation with any other variables while social compensation and social loafer’s continuous social loafing were two serial mediators in the relationship between perceived social loafing and team performance. Specifically, when students perceived that their teammates engaged in social loafing,they exerted more effort to compensate for the social loafers, this way of reaction made the social loafers continue putting forth less effort and, in consequence, the overall team performance was low.