bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway
Authors: Xu Yuanhui , Jia Keliang , Zhao Xianhai , Li Yuantao , Zhang Zhen 
Published: December 2023

AbstractThe role of LINC01703 in cancers, especially in colorectal cancer (CRC), is still largely unclear. Bioinformatics prediction, real‐time quantitative polymerase chain reaction (RT‐qPCR), 3‐(4,5)‐dimethylthiahiazo (‐z‐y1)−3,5‐di‐phenytetrazoliumromide (MTT) assay, colony formation assay, Transwell assays, in vivo animal experiments, IF, luciferase reporter assay, and Western blot were carried out for the exploration of the potential involvement and underlying molecular mechanisms of LINC01703 in CRC cells. The results showed that LINC01703 appeared upregulated in CRC and was linked to poor prognosis. LINC01703 acted as an oncogene in both in vitro and in vivo CRC cell environments. LINC01703 activated the PI3K/AKT signaling pathway by mediating the miR‐205‐5p/E2F1 axis in CRC. In summary, LINC01703 possesses an oncogenic function and can be a possible biomarker or target to treat CRC.
Effects of body part thickness on low‐contrast detail detection and radiation dose during adult chest radiography
Authors: Al‐Murshedi Sadeq , Alzyoud Kholoud , Benhalim Mohamed , Alresheedi Nadi , Papathanasiou Stamatia , England Andrew 
Published: December 2023

AbstractIntroductionDifferences in patient size often provide challenges for radiographers, particularly when choosing the optimum acquisition parameters to obtain radiographs with acceptable image quality (IQ) for diagnosis. This study aimed to assess the effect of body part thickness on IQ in terms of low‐contrast detail (LCD) detection and radiation dose when undertaking adult chest radiography (CXR).MethodsThis investigation made use of a contrast detail (CD) phantom. Polymethyl methacrylate (PMMA) was utilised to approximate varied body part thicknesses (9, 11, 15 and 17 cm) simulating underweight, standard, overweight and obese patients, respectively. Different tube potentials were tested against a fixed 180 cm source to image distance (SID) and automatic exposure control (AEC). IQ was analysed using bespoke software thus providing an image quality figure inverse (IQFinv) value which represents LCD detectability. Dose area product (DAP) was utilised to represent the radiation dose.ResultsIQFinv values decreased statistically (P = 0.0001) with increasing phantom size across all tube potentials studied. The highest IQFinv values were obtained at 80 kVp for all phantom thicknesses (2.29, 2.02, 1.8 and 1.65, respectively). Radiation dose increased statistically (P = 0.0001) again with increasing phantom thicknesses.ConclusionOur findings demonstrate that lower tube potentials provide the highest IQFinv scores for various body part thicknesses. This is not consistent with professional practice because radiographers frequently raise the tube potential with increased part thickness. Higher tube potentials did result in radiation dose reductions. Establishing a balance between dose and IQ, which must be acceptable for diagnosis, can prevent the patient from receiving unnecessary additional radiation dose.
Characterizing enterovirus C96 genome and phylodynamics analysis
Authors: Yang Tingting , Sun Qiang , Yan Dongmei , Zhu Shuangli , Ji Tianjiao , Xiao Jinbo , Lu Huanhuan , Liu Ying , He Yun , Wang Wenhui , Cong Ruyi , Wang Xiaoyi , Yang Qian , Xing Weijia , Zhang Yong 
Published: December 2023

AbstractEnterovirus C96 (EV‐C96) is a recently discovered serotype belonging to enterovirus C species. It had been isolated from patients with acute flaccid paralysis, hand, foot, and mouth disease, diarrhea, healthy people, or environmental specimens. Despite increasing reports of the virus, the small number of full‐length genomes available for EV‐C96 has limited molecular epidemiological studies. In this study, newly collected rare EV‐C96 strains in China from 1997 to 2020 were combined with sequences available in GenBank for comprehensive analyses. Sequence analysis revealed that the nucleotide sequence similarity of EV‐C96 and the prototype strain (BAN00‐10488) was 75%–81.8% and the amino acid sequence similarity was 85%–94.9%. EV‐C96 had a high degree of genetic variation and could be divided into 15 genogroups. The mean evolutionary rate was 5.16 × 10−3 substitution/site/year, and the most recent common ancestor was dated to 1925. A recombination analysis revealed that EV‐C96 may be a recombinant derived from other serotypes in the EV‐C group in the nonstructural protein coding region. This comprehensive and integrated analysis of the whole genome sequence of EV‐C96 provides valuable data for further studies on the molecular epidemiology of EV‐C96 worldwide.
Co‐evolution of governance mechanisms and coopetition in public‐private projects
Authors: Rouyre Audrey , Fernandez Anne‐Sophie , Estrada Isabel 
Published: December 2023

AbstractOne important question in public‐private (PP) projects is how to manage coopetition—simultaneous cooperation and competition among project members. Prior studies on the governance of PP projects showed the importance of governance mechanisms to deal with major events such as technical or organizational disruptions but paid limited attention to the management of coopetition. At the same time, research on the management of coopetition mostly focused on industrial coopetition, whereas PP projects also entail public‐private coopetition. Seeking to better understand how governance mechanisms may help manage coopetition in PP projects, we conducted an in‐depth study of Galileo—a large PP project aimed at delivering Europe's own satellite‐based navigation system. The findings show how three core aspects of project governance—(i) mechanisms (joint vs. separate use of contractual and relational mechanisms), (ii) form (lead organization vs. shared governance), and (iii) goals (to promote cooperation and/or prevent competition)—jointly explained the emergence and (mis)management of knowledge‐ and value‐related coopetitive tensions. In turn, these tensions prompted a series of adaptations in the governance of the project. Our study contributes to a co‐evolutionary understanding of the governance of PP projects and offers implications for practitioners seeking to (re)design PP project governance.
When health care sickens the health care worker: Commentary on Park et al. (2023)
Authors: Lederer Wolfgang 
Published: December 2023

AbstractIn their survey, Park and colleagues (2023) reported that many health care and hospital workers perceived that their safety was not a priority during the COVID‐19 pandemic, with 33.9% of responders feeling betrayed by institutional leaders. Employees of the health care system reported being viewed more as servants than specialists during the pandemic, and they noted that critical assessment and the expression of one's own opinion were unwelcome (Lederer, 2023). A lack of epidemiologic knowledge was compensated with the inflexible strategy of a hierarchical system. Opting out of testing and vaccination justified exposure, discrimination, and humiliation. Paternalism, a lack of esteem, and complete exhaustion further contributed to the physical and mental health toll of the pandemic on health care and hospital workers.
Preoperative Imaging in Patients with 22q11 Deletion Syndrome Undergoing Velopharyngeal Surgery
Authors: Duckett Kelsey A. , Poupore Nicolas S. , Carroll William W. , Pecha Phayvanh P. 
Published: December 2023

ObjectiveTo evaluate the utility of preoperative imaging before velopharyngeal dysfunction (VPD) surgery in children with 22q11 Deletion Syndrome (22qDS) in evaluating internal carotid artery (ICA) medialization.Data SourcesPubMed, Scopus, and CINAHL.Review MethodsFollowing PRISMA guidelines, a systematic review was performed. Studies of children with 22qDS who underwent preoperative imaging (MRA or CTA) to identify ICA anomalies were included. High‐risk medialized ICAs were defined as either submucosal, retropharyngeal, Pfeiffer Grade III‐IV, or <3 mm from the pharyngeal mucosa. Meta‐analyses of proportions were performed.ResultsEleven studies met inclusion criteria, comprising 398 patients with 22qDS (weighted mean age 7.6 years). In 372 patients with imaging, the rate of ICA medialization on imaging was 47.1% (95%CI 29.2–65.5), of which 46.3% (95%CI 27.4–65.8) were determined high risk. Operative plans were modified in 19.4% (95%CI 5.7–38.8) of 254 surgeries due to medialized ICA. In studies attempting to use nasopharyngoscopy pulsations to identify medialization for 214 patients, the true‐positive rate was 53.9% (95%CI 27.5–79.2) and the false‐positive rate was 16.2% (95%CI 7.9–26.8). Nine of eleven studies (81.8%) recommended universal preoperative imaging of the ICAs in children with 22qDS undergoing VPD surgery. No cases of perioperative bleeding secondary to ICA injury were identified.ConclusionAlthough most studies endorse routine preoperative imaging to assess for ICA medialization in children with 22qDS undergoing VPD surgery, only a minority of these cases led to surgical modification. Additional studies are needed to compare outcomes in children with and without preoperative imaging given the low rates of ICA injury in the literature.Level of EvidenceN/A Laryngoscope, 134:2551–2561, 2024
Metasurfaces toward Optical Manipulation Technologies for Quantum Precision Measurement
Authors: Xu Yan , Su Xinran , Chai Zhen , Li Jianli 
Published: December 2023

AbstractMetasurface‐based optical field manipulation has significantly broadened the application range of micro‐optical components and integrated optics, gradually replacing bulky and complicated optical components. With the continuous development of micro and nano processing technology as well as computational analysis technology, metasurfaces have progressively shown their superior application prospects. After demonstrating tremendous results in classical optical applications, their application range has now extended to the field of quantum sensing. Due to their unique properties, such as small planar size, easy integration, flexible performance design, and tunable functionality, they have opened up a series of novel and rich applications for generating, manipulating, controlling, and detecting optical fields. In this paper, the basic principle and implementation of quantum measurement are presented and an overview of the design principles of metasurfaces, along with a summary of the latest advancements and potential applications of these surfaces in optical field modulation techniques for quantum precision measurement. Additionally, a thorough discussion and analysis of the challenges encountered by metasurfaces and their future development prospects is provided. Metasurfaces offer brand‐new opportunities for low‐cost, high‐performance, multifunctional miniaturized quantum sensors and are expected to play a significant role in the development of next‐generation quantum sensors.
Integrative analyses of N6‐methyladenosine‐associated single‐nucleotide polymorphisms (m6A‐SNPs) identify tumor suppressor gene AK9 in lung cancer
Authors: Hua Tingting , Zhang Chang , Fu Yating , Qin Na , Liu Su , Chen Congcong , Gong Linnan , Ma Huimin , Ding Yue , Wei Xiaoxia , Jin Chenying , Jin Chen , Zhu Meng , Zhang Erbao , Dai Juncheng , Ma Hongxia 
Published: December 2023

AbstractN6‐methyladenosine (m6A) modification has been identified as one of the most important epigenetic regulation mechanisms in the development of human cancers. However, the association between m6A‐associated single‐nucleotide polymorphisms (m6A‐SNPs) and lung cancer risk remains largely unknown. Here, we identified m6A‐SNPs and examined the association of these m6A‐SNPs with lung cancer risk in 13,793 lung cancer cases and 14,027 controls. In silico functional annotation was used to identify causal m6A‐SNPs and target genes. Furthermore, methylated RNA immunoprecipitation and quantitative real‐time polymerase chain reaction (MeRIP‐qPCR) assay was performed to assess the m6A modification level of different genotypes of the causal SNP. In vitro assays were performed to validate the potential role of the target gene in lung cancer. A total of 8794 m6A‐SNPs were detected, among which 397 SNPs in nine susceptibility loci were associated with lung cancer risk, including six novel loci. Bioinformatics analyses indicated that rs1321328 in 6q21 was located around the m6A modification site of AK9 and significantly reduced AK9 expression (β = −0.15, p = 2.78 × 10−8). Moreover, AK9 was significantly downregulated in lung cancer tissues than that in adjacent normal tissues of samples from the Cancer Genome Atlas and Nanjing Lung Cancer Cohort. MeRIP‐qPCR assay suggested that C allele of rs1321328 could significantly decrease the m6A modification level of AK9 compared with G allele. In vitro assays verified the tumor‐suppressing role of AK9 in lung cancer. These findings shed light on the pathogenic mechanism of lung cancer susceptibility loci linked with m6A modification.
Gaze measurements during viewing human dialogue scenes in adults with ADHD: Preliminary findings
Authors: Nagatsuka Yuta , Nakamura Dan , Ota Marie , Arai Gosuke , Iwami Yuriko , Suzuki Hirohisa , Tomita Akisa , Hanawa Yoichi , Hayashi Wakaho , Iwanami Akira 
Published: December 2023

AbstractAimEye gaze measurement to human dialogue scenes in adults with attention deficit hyperactivity disorder (ADHD) was investigated. We examined whether eye gaze measurement might be a biological marker of ADHD.MethodsTwenty‐two individuals with ADHD (mean age, 34.5 years) attending the outpatient clinic of Showa University Karasuyama Hospital were included in the study, and 26 healthy individuals (mean age, 32.6 years) with no history of mental disorders were used as the control group. For the participants, intellectual functioning was estimated using the Japanese Adult Reading Test, and mental symptoms were assessed using the Autism Spectrum Quotient and Conner's Adult ADHD Rating Scale. We extracted human dialogue scenes from two classic movies as visual stimuli and recorded the participant's gaze while watching these scenes using Tobii's eye tracker.ResultsFor gazing time, repeated measures analysis of variance showed no significant main effect of “group” and no significant interaction effect between “group” and areas of interest “(AOI).” In the normal group, gazing time at the eyes was significantly longer than those at the mouth, body, and background; in the ADHD group, gazing time at the eyes was significantly longer than only that at the background.ConclusionGiven the different results obtained in the past in ASD, these results suggest that it would be necessary to directly compare the two groups to determine whether the gaze measurement shows significant differences in ASD and ADHD.
Laser processes are shaping e‐mobility in Europe
Authors: Castelo Antonio 
Published: December 2023

AbstractEurope needs a battery industry. Internal combustion is a mastered technology on the old continent, but European companies need to improve their electric vehicle capabilities to reduce the gap to other markets. A collaborative approach is critical to succeeding in this objective, as is creating a European ecosystem that could work as a local supply base for the battery manufacturers and the automotive companies.
Study on the synthesis mechanism of pyrazoles via [3+2] cycloaddition reaction of diazocarbonyl compounds with enones without leaving groups
Authors: Feng Guipeng , Meng Jie , Xu Shaohong , Wang Chenqian , Yao Xubin , Nie Xinzi 
Published: December 2023

AbstractOn the basis of the density functional theory (DFT), the process of cycloaddition reaction of diazocarbonyl compounds with enones without leaving groups to obtain pyrazoles was proposed. First, the diazocarbonyl compounds reacted with enones to offer the intermediates by cycloaddition reaction, which was captured of hydrogen of the intermediate by the base to offer the nonaromatic pyrazole intermediate, which then give the final product by oxidation and isomerization in the air. This protocol corrected the reaction mechanism that was proposed in the experimental section. The negative correlation between the yields of products with the charges of ADCH at the C1 position of enones was also founded, which was consistent with the experimental results. The protocol could provide theoretical guidance for designing more efficient cycloaddition reaction.
Bronchopulmonary dysplasia in adults: Exploring pathogenesis and phenotype
Authors: Wozniak Phillip S. , Makhoul Lara , Botros Mena M. 
Published: December 2023

AbstractThis review highlights both the longstanding impact of bronchopulmonary dysplasia (BPD) on the health of adult survivors of prematurity and the pressing need for prospective, longitudinal studies of this population. Conservatively, there are an estimated 1,000,000 survivors of BPD in the United States alone. Unfortunately, most of the available literature regarding outcomes of lung disease due to prematurity naturally focuses on pediatric patients in early or middle childhood, and the relative amount of literature on adult survivors is scant. As the number of adult survivors of BPD continues to increase, it is essential that both adult and pediatric pulmonologists have a comprehensive understanding of the pathophysiology and underlying disease process, including the molecular signaling pathways and pro‐inflammatory modulators that contribute to the pathogenesis of BPD. We summarize the most common presenting symptoms for adults with BPD and identify the critical challenges adult pulmonologists face in managing the care of survivors of prematurity. Specifically, these challenges include the wide variability of the clinical presentation of adult patients, comorbid cardiopulmonary complications, and the paucity of longitudinal data available on these patients. Adult survivors of BPD have even required lung transplantation, indicating the high burden of morbidity that can result from premature birth and subsequent lung injury. In addition, we analyze the disparate symptoms and management approach to adults with “old” BPD versus “new” BPD. The aim of this review is to assist pulmonologists in understanding the underlying pathophysiology of BPD and to improve clinical recognition of this increasingly common pulmonary disease.
Home ventilation in low resource settings: Learning to do more, with less
Authors: Zampoli Marco , Booth Jane , Gray Diane M. , Vanker Aneesa 
Published: December 2023

AbstractLong‐term ventilation (LTV) in children at home, especially invasive ventilation, is not widely available nor practised in low‐resource settings (LRS). Barriers to providing LTV include underdeveloped pediatric critical care services, limited expertise in pediatric LTV, limited capacity to screen for sleep‐disordered breathing (SDB) and high cost of LTV equipment and consumables. Additional challenges encountered in LRS may be unreliable electricity supply and difficult socioeconomic conditions. Where LTV at home has been successfully implemented, caregivers and families in LRS must often take full responsibility for their child's care as professional home‐based nursing care is scarce. Selecting suitable children and families to offer LTV in LRS may therefore face difficult ethical decisions when families are disempowered or incapable of providing 24‐h care at home. Early caregiver participation and hands‐on training in tracheostomy care and LTV equipment is key to success, irrespective of the caregiver's level of education. The use of overnight oximetry, mobile phone technology, spirometry, and clinical evaluation are simple tools that can aid recognition and monitoring of children needing LTV. As children survive longer supported by LTV, engaging with adult services at an early stage is important to ensure suitable pathways for transition to adult care are in place. Building capacity and expertise in pediatric LTV in LRS requires targeted training of health professionals in related disciplines and advocacy to policymakers and funders that LTV in appropriately selected circumstances is worthwhile, life‐changing, and cost‐saving.
Model‐based meta‐analysis using latent variable modeling to set benchmarks for new treatments of systemic lupus erythematosus
Authors: Goteti Kosalaram , Garcia Ramon , Gillespie William R. , French Jonathan , Klopp‐Schulze Lena , Li Ying , Mateo Cristina Vazquez , Roy Sanjeev , Guenther Oliver , Benincosa Lisa , Venkatakrishnan Karthik 
Published: December 2023

AbstractSeveral investigational agents are under evaluation in systemic lupus erythematosus (SLE) clinical trials but quantitative frameworks to enable comparison of their efficacy to reference benchmark treatments are lacking. To benchmark SLE treatment effects and identify clinically important covariates, we developed a model‐based meta‐analysis (MBMA) within a latent variable model framework for efficacy end points and SLE composite end point scores (BILAG‐based Composite Lupus Assessment and Systemic Lupus Erythematosus Responder Index) using aggregate‐level data on approved and investigational therapeutics. SLE trials were searched using PubMed and www.clinicaltrials.gov for treatment name, SLE and clinical trial as search criteria that resulted in four data structures: (1) study and investigational agent, (2) dose and regimen, (3) baseline descriptors, and (4) outcomes. The final dataset consisted of 25 studies and 81 treatment arms evaluating 16 different agents. A previously developed (K Goteti et al. 2022) SLE latent variable model of data from placebo arms (placebo + standard of care treatments) was used to describe aggregate SLE end points over time for the various SLE placebo and treatment arms in a Bayesian MBMA framework. Continuous dose‐effect relationships using a maximum effect model were included for anifrolumab, belimumab, CC‐220 (iberdomide), epratuzumab, lulizumab pegol, and sifalimumab, whereas the remaining treatments were modeled as discrete dose effects. The final MBMA model was then used to benchmark these compounds with respect to the maximal efficacy on the latent variable compared to the placebo. This MBMA illustrates the application of latent variable models in understanding the trajectories of composite end points in chronic diseases and should enable model‐informed development of new investigational agents in SLE.
Potassium homeostasis and therapeutic intervention with sodium zirconium cyclosilicate: A model‐informed drug development case study
Authors: Clegg Lindsay E. , Chu Lulu , Nagard Mats , Boulton David W. , Penland Robert C. 
Published: December 2023

AbstractPotassium (K+) is the main intracellular cation in the body. Elevated K+ levels (hyperkalemia) increase the risk of life‐threatening arrhythmias and sudden cardiac death. However, the details of K+ homeostasis and the effects of orally administered K+ binders, such as sodium zirconium cyclosilicate (SZC), on K+ redistribution and excretion in patients remain incompletely understood. We built a fit‐for‐purpose systems pharmacology model to describe K+ homeostasis in hyperkalemic subjects and capture serum K+ (sK+) dynamics in response to acute and chronic administration of SZC. The resulting model describes K+ distribution in the gastrointestinal (GI) tract, blood, and extracellular and intracellular spaces of tissue, renal clearance of K+, and K+–SZC binding and excretion in the GI tract. The model, which was fit to time‐course sK+ data for individual patients from two clinical trials, accounts for bolus delivery of K+ in meals and oral doses of SZC. The virtual population of patients derived from fitting the model to these trials was then modified to predict the SZC dose–response and inform clinical trial design in two new applications: emergency lowering of sK+ in severe hyperkalemia and prevention of hyperkalemia between dialysis sessions in patients with end‐stage chronic kidney disease. In both cases, the model provided novel and useful insight that was borne out by the now completed clinical trials, providing a concrete case study of fit‐for‐purpose, model‐informed drug development after initial approval of a drug.