bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of State COVID-19 Responses on People With Intellectual and Developmental Disabilities
Authors: Lineberry Sarah , Bogenschutz Matthew , Dinora Parthenia 
Published: February 2025

Abstract
Evidence suggests that the public health response to the COVID-19 pandemic exacerbated existing inequities, including for people with intellectual and developmental disabilities (IDD). People with IDD may have been at a higher risk for poor outcomes from COVID-19 than people without disabilities, but they were rarely prioritized in the public health response. Using multilevel modeling, we explored the impact of individual-level differences in combination with state-level policies on the likelihood of contracting COVID-19. Findings suggest that the ways people with IDD interact with their community, including where they live, impacted their risk during the COVID-19 pandemic, supporting calls to more actively consider people with IDD in future public health emergencies.
Predicting IVF live -birth probability using time-lapse data: Implications of including or excluding age in a day 2 embryo transfer model
Authors: Sayed Shabana , Petersen Bjørn Molt , Reigstad Marte Myhre , Schwennicke Arne , Hausken Jon Wegner , Storeng Ritsa 
Published: February 2025

The primary objective of this study was to develop predictive models for the likelihood of live births following In Vitro Fertilisation (IVF) treatment, based on a retrospective analysis of time-lapse data from Day 2 embryo transfers at Klinikk Hausken, Norway. This analysis encompassed 1,506 IVF treatment cycles, which included 865 single and 641 double embryo transfer cycles, totalling 2,147 embryos transferred.
The model covariates included nucleation error, timing of two-cell stage (t2) and duration between t2 and the three-cell stage (t3). The predictive ability was assessed using Area Under Curve (AUC). Generalised Additive Mixed Models (GAMM) were utilised to address clustering effects from Single Embryo Transfers (SET) and Double Embryo Transfers (DETs), as well as the non-linear effects of female age and t2 timings. A stratification of age and model scores demonstrated the impact of incorporating age into the model. The” Base Model, not incorporating age, achieved an AUC of 0.641, while the “Age Model”, using maternal age, significantly enhanced AUC to 0.745, as estimated through bootstrap analysis.
However, when the Age Model was subjected to average ages across three respective age intervals, the AUC values were comparable to the Base Model, rather than the original Age Model scores.
Adjusting the Intracytoplasmic Sperm Injection (ICSI) timing by ± 2 hours, purely as a theoretical exercise, has minimal impacts on model predictions. This highlights the value of including t2 despite fertilisation timing variations between ICSI and IVF.
The Age Model did not show superiority in predicting live birth within single treatment cohorts. However, given its distinct AUC values for broader age ranges, the Age Model can serve as a counselling tool on live-birth probabilities. With further validation, we suggest only using the Age Model for general counselling, while the Base Model is preferable for the embryo selection decision support.
Comparison of leg length discrepancy after total hip arthroplasty: Direct anterior and posterior lateral approach
Authors: Lu Yang , Li Xiang , Hu Yihe , Zhao Fengchao 
Published: February 2025

Background
Leg length discrepancy (LLD) after total hip arthroplasty (THA) is a clinical entity that deteriorates clinical outcomes and patients’ satisfaction. Few articles have compared LLD after THA by different surgical approaches.

Methods
A total of 358 consecutive patients who underwent primary THA between January 2016 and November 2018 were retrospectively reviewed. All 4 surgeons performed THA through both direct anterior approach (DAA) and posterior lateral approach (PLA). The primary outcome measurement was LLD. LLD was measured on post-operative anteroposterior bilateral hip radiograph. The secondary outcomes were acetabular abduction, acetabular anteversion, perceived LLD (pLLD) and HHS at 6 weeks, 1 year and 5 years. Intergroup analyses were performed using the Chi-square test for enumeration data and the independent sample t-test for quantitative data.

Results
There was no inter-group difference in terms of patients’ demographics. The DAA group had decreased LLD compared to the PLA group (3.0 ± 5.9mm vs. 4.2 ± 4.5mm, p = 0.027). Meanwhile, the DAA group had a smaller acetabular anteversion than the PLA group (12.9 ± 2.9 vs. 18.4 ± 2.9, p < 0.01). At 6-week follow-up, the DAA group had higher HHS (82.2 + 6.2 vs. 80.5 + 6.6, p = 0.015) and less pLLD (P = 0.001) compared to the PLA group.

Conclusions
DAA results in more accurate leg length equalization, reduced pLLD, and improved short-term outcomes compared with PLA.
Astragalus polyphenols attenuates doxorubicin-induced cardiotoxicity by activating the PI3K/AKT/NRF2 pathway
Authors: Bai Xueyang , Wei Hua , Liu Gangqiong , Li Ling 
Published: February 2025

Background
Doxorubicin (DOX) is a powerful chemotherapeutic agent commonly employed in cancer treatment. However, its clinical utility is constrained by dose-dependent cardiotoxicity, which can result in heart failure and sudden cardiac death. The molecular mechanisms of DOX-induced cardiotoxicity (DIC) include oxidative stress, mitochondrial dysfunction, and the activation of cell death pathways, including ferroptosis. There is an urgent need for effective therapeutic strategies to mitigate DIC.

Methods
This study investigates the cardioprotective effects of Astragalus Polyphenols (ASP), a bioactive compound extracted from Astragalus membranaceus. In the context of DIC, we utilized AC16 and H9C2 cardiomyocytes to establish a DIC model and assessed the effects of ASP on cell viability, oxidative stress, mitochondrial function, and the PI3K/AKT/NRF2 signaling pathway. The expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), markers of cardiac injury, was also evaluated.

Results
ASP treatment significantly reversed DOX-induced reductions in cell viability and mitochondrial membrane potential (MMP) while also decreasing the levels of reactive oxygen species (ROS). Additionally, ASP also downregulated the expression of ANP and BNP, indicating a protective effect on cardiomyocytes. Furthermore, ASP activated the PI3K/AKT/NRF2 pathway, which was suppressed by DOX. Inhibition of this pathway using LY294002 and ML385 abolishes the protective effects of ASP, suggesting that ASP mediates its effects through the PI3K/AKT/NRF2 signaling axis.

Conclusion
ASP exhibits a protective effect against DOX-induced cardiotoxicity by regulating the PI3K/AKT/NRF2 pathway to reduce oxidative stress and preserve mitochondrial function. These findings suggest that ASP may serve as a potential therapeutic agent to alleviate DIC. Our results provide a novel strategy to protect the heart in patients undergoing DOX chemotherapy.
Evaluation of psychiatric conditions in asymptomatic outpatient clinic patients
Authors: Erinc Osman , Yesilyurt Soner 
Published: February 2025

Introduction
A significant part of the internal medicine outpatient clinic burden consists of patients who are asymptomatic and intend to have routine check-up tests. In this study, we aimed to investigate the relationship between visit frequency within a year and the undiagnosed anxiety, depressive mood or obsessive-compulsive disorder.

Methods
We included in our study 129 participants who applied for routine check-up tests to our hospital’s internal medicine outpatient clinic, without any complaint and known diseases. Individuals were divided into two groups: Group 1 comprised individuals who applied once a year, whereas Group 2 included those who applied more than once a year. Participants underwent routine blood testing, and their mental health was assessed with the Beck`s Depression Inventory (BDI), Beck`s Anxiety Inventory (BAI), and Vancouver Obsessinal Compulsive Inventory (VOCI).

Results
66% of the 129 participants included in the study were female (n = 85/44, p < 0.001). When laboratory parameters were examined, no significant difference was found except serum vitamin D levels (14.5/19.8 µg/L, p = 0.024, respectively). BDI and BAI scores were statistically significantly higher in Group 2 (10/14, p = 0.032, 11/13.5, p = 0.027, respectively). There was no difference between the two groups in terms of VOCI scores.

Conclusion
Asymptomatic patients who are visiting clinics for routine checkups constitute a significant part of the outpatient clinic workload. Assessing the mental health of patients who are attending frequently might be helpful in reducing this burden as well as in diagnosing and initiating treatment of undiagnosed underlying mental disorders. To ensure timely referrals of these patients to psychiatry, an adequate referral system and awareness of early signs of anxiety and depression among healthcare professionals are needed.
Plasma attenuates endothelial injury compared to crystalloids in a ventilated rat pneumosepsis model
Authors: van den Brink Daan P. , Kleinveld Derek J.B. , Polet Chantal A. , Veltman Hendrik , Roelofs Joris J.T.H. , Weber Nina C. , Juffermans Nicole P. 
Published: February 2025

Background
The dysregulated immune response during sepsis involves endothelial injury, which may be augmented by infusion of clear fluids such as crystalloids. Plasma has been suggested as an alternative resuscitation fluid but it is unclear whether previously observed benefits were due to the type of fluid, or due to less volume required to restore tissue perfusion. We hypothesized that resuscitation with plasma reduces endothelial injury, inflammation, and organ injury compared to similar and higher volumes of crystalloids in a rat pneumosepsis model.

Methods
Rats were intratracheally inoculated with Streptococcus Pneumoniae to induce pneumosepsis. Twenty-four hours after inoculation, animals were randomized to 4 groups: healthy controls (non-resuscitated, n = 6), 10 ml/kg/hr (standard-volume, n = 11) crystalloid resuscitation, 3.33 ml/kg/hr (low-volume, n = 11) crystalloid resuscitation or 3.33 ml/kg/hr plasma resuscitation (n = 11). Plasma markers of inflammation and endothelial injury were measured. Organs were harvested for histology and wet-to-dry weight ratio determination.

Results
Inoculated animals developed pneumosepsis, with lower mean arterial pressures (p < 0.001) and higher lactate levels (p < 0.001) compared to healthy controls. Animals resuscitated with plasma showed a trend towards lower syndecan-1 levels compared to the standard-volume crystalloid group (82 vs 99 ng/mL, p = 0.06) and had lower levels of VCAM-1 (424 vs 592 ng/mL, p < 0.01) compared to the standard volume crystalloid group, but not when compared to the low-volume crystalloid group. Other markers of endothelial injury or inflammation were not significantly different between groups. No significant differences were observed in histologic injury scores and wet-to-dry ratios.

Conclusion
Plasma resuscitation modestly reduces endothelial injury compared to crystalloid resuscitation. This effect might be attributed to decreased resuscitation volumes rather than the type of fluid.
Vocational rehabilitation for people with multiple sclerosis in the national health service of the United Kingdom: A realist evaluation
Authors: De Dios Perez Blanca , Booth Vicky , das Nair Roshan , Evangelou Nikos , Hassard Juliet , Ford Helen L. , Newsome Ian , Radford Kate 
Published: February 2025

Background
There is limited evidence about how vocational rehabilitation (VR) for people with multiple sclerosis (MS) can be delivered through the United Kingdom’s (UK) National Health Service (NHS) and how it works.

Aim
To understand the mechanisms and context for implementing a VR intervention for people with MS in the NHS and develop an explanatory programme theory.

Methods
A realist evaluation, including a review of evidence followed by semi-structured interviews. A realist review about VR for people with MS in the NHS was conducted on six electronic databases (PubMed, MEDLINE, PsychINFO, Web of Science, CINAHL, and EMBASE) with secondary purposive searches. Included studies were assessed for relevance and rigour. Semi-structured interviews with people with MS, employers, and healthcare professionals, were conducted remotely. Data were extracted, analysed, and synthesised to refine the programme theory and produce a logic model.

Results
Data from 13 studies, and 19 interviews (10 people with MS, five employers, and four healthcare professionals) contributed to producing the programme theory. The resulting programme theory explains the implementation of VR in the NHS for MS populations, uncovering the complex interplay between the healthcare and employment sectors to influence health and employment outcomes. VR programmes that offer timely support, tailored to the needs of the person with MS, and that support and empower the employee beyond the healthcare context are most likely associated with improved employment outcomes, for example, job retention.

Conclusion
Embedding VR support within the NHS requires substantial cultural and organisational change (e.g., increased staff numbers, training, and awareness about the benefits of work). This study emphasises the need to routinely identify people with MS at risk of job loss and follow a collaborative approach to address employment issues. This realist evaluation provides insight on how to improve the quality of care available to people with MS.
Poor sleep patterns are associated with the prevalence of benign prostatic hyperplasia in US aged 40 and older: A cross-sectional study based on NHANES
Authors: Zhao Dingliang , Han Junjie , Lv Chengsen , Gao Jialin 
Published: February 2025

Background
The connection between sleep patterns (sleep duration, trouble sleeping and sleep disorders) and benign prostatic hyperplasia, commonly referred to as BPH, is not yet clear. Our aim is to investigate the impact of sleep patterns on BPH risk in US men aged 40 and older.

Methods
We performed an observational analysis using data from NHANES 2005–2008 on males aged 40 and up, including a total of 2,555 participants. After accounting for confounding variables, we applied weighted multivariable logistic regression to assess the relationship between sleep patterns and BPH risk according to the complex multi-stage sampling design of NHANES.

Results
In this study, 11.79% of the 2,555 American participants aged over 40 reported to have BPH. after adjusting for confounding variables, multivariable logistic regression analysis showed that short sleep duration, compared to healthy sleep duration (7–9 hours), was linked to a significantly higher risk of BPH (OR: 1.92, 95% CI: 1.42–2.41). Trouble sleeping and sleep disorder were also strongly associated with BPH. Moreover, there appears to be a stronger association among those with poor sleep patterns (OR: 2.07, 95% CI: 1.46–2.91).

Conclusion
Poor sleep patterns in men over 40 in the U.S. is significantly linked to a higher incidence of benign prostatic hyperplasia.
Machine learning for predicting antimicrobial resistance in critical and high-priority pathogens: A systematic review considering antimicrobial susceptibility tests in real-world healthcare settings
Authors: Ardila Carlos M. , González-Arroyave Daniel , Tobón Sergio 
Published: February 2025

Background
Antimicrobial resistance (AMR) poses a worldwide health threat; quick and accurate identification of AMR enhances patient outcomes and reduces inappropriate antibiotic usage. The objective of this systematic review is to evaluate the efficacy of machine learning (ML) approaches in predicting AMR in critical and high-priority pathogens (CHPP), considering antimicrobial susceptibility tests in real-world healthcare settings.

Methods
The search methodology encompassed the examination of several databases, such as PubMed/MEDLINE, EMBASE, Web of Science, SCOPUS, and SCIELO. An extensive electronic database search was conducted from the inception of these databases until November 2024.

Results
After completing the final step of the eligibility assessment, the systematic review ultimately included 21 papers. All included studies were cohort observational studies assessing 688,107 patients and 1,710,867 antimicrobial susceptibility tests. GBDT, Random Forest, and XGBoost were the top-performing ML models for predicting antibiotic resistance in CHPP infections. GBDT exhibited the highest AuROC values compared to Logistic Regression (LR), with a mean value of 0.80 (range 0.77–0.90) and 0.68 (range 0.50–0.83), respectively. Similarly, Random Forest generally showed better AuROC values compared to LR (mean value 0.75, range 0.58–0.98 versus mean value 0.71, range 0.61–0.83). However, some predictors selected by these algorithms align with those suggested by LR.

Conclusions
ML displays potential as a technology for predicting AMR, incorporating antimicrobial susceptibility tests in CHPP in real-world healthcare settings. However, limitations such as retrospective methodology for model development, nonstandard data processing, and lack of validation in randomized controlled trials must be considered before applying these models in clinical practice.
Acute and sub-acute toxicity of ethanol extracts of Hagenia abyssinica and Rumex abyssinicus flowers in Swiss albino mice
Authors: Gemeda Hirut Basha , Debella Asfaw , Endale Milkyas , Abebe Abiy , Mathewos Meharu , Habtu Wossene , Chalchisa Dinkenesh , Getachew Betelhem , Hassen Menal , Mamo Hassen 
Published: February 2025

Background
Hagenia abyssinica (Bruce) J.F. Gmel (Family: Rosaceae) and Rumex abyssinicus Jacq (Family: Polygonaceae) are valuable medicinal plants traditionally used in Ethiopia to treat various diseases. Recent studies have also demonstrated that solvent extracts of these plants exhibit molluscicidal activities under laboratory conditions, highlighting their potential for snail control. However, limited information is available regarding their safety profiles.

Objective
This study aimed to evaluate acute, and sub-acute toxicity of 70% ethanol extracts of H. abyssinica and R. abyssinicus flowers in Swiss albino mice, following the Organization for Economic Co-operation and Development guidelines 423 and 407.

Methods
In the acute toxicity study, both extracts were administered orally to experimental groups at varying concentrations (mg/kg bodyweight): 5, 50, 300, and 2000. For the sub-acute toxicity study, both extracts were given to the experimental groups at doses (mg/kg) of 125, 250, and 500 daily for 28 days. Blood samples were collected from each mouse and analyzed for hematological and biochemical parameters. Additionally, the heart, liver, and kidneys were excised, stained, and examined for potential histopathological effects.

Results
The acute toxicity study revealed no noticeable changes in behavior at the highest oral dosage of 2000 mg/kg. In the sub-acute toxicity study, no statistically significant changes were observed in hematological and biochemical parameters compared to the control group. Similarly, no abnormal histological findings were noted in the examined organs in comparison to the control group.

Conclusion
These findings indicate that flower extracts of both plants did not show significant toxicity to laboratory mammals at an oral dosage of 2000 mg/kg.
Advancing data-driven process modeling in metal forming
Authors: Liewald Mathias , Vogel-Heuser Birgit , Bergs Thomas , Huber Marco , Kröger Peer 
Published: February 2025

Abstract
The production of metal forming technology products until now requires substantial expertise from specialists in product, process, and equipment design. Particularly important is the ability to compensate for stochastic, unpredictable process deviations. Given this context, a newly established Priority Program 2422 (PP 2422) by the German Research Foundation (DFG) aims to enhance the current FEM-simulation-based design of the active surfaces of metal forming tools with data-driven modeling. The present paper firstly summarizes the current state of the art in data-based process modelling in this technology. Subsequently, the research questions addressed by the PP 2422 and the concept of interdisciplinary cooperation between metal forming, automation and data science are explained.
On k-Circulant matrices involving the Lucas numbers of even index
Authors: Radičić Biljana 
Published: February 2025

Abstract
Let k be a nonzero complex number. In this paper, we consider a k-circulant matrix whose first row is (L
2, L
4, … , L
2n
), where Ln
is the nth
Lucas number. The formulae for the eigenvalues of such matrix are obtained. Namely, the result which can be obtained from Theorem 2 of [Bueno, A.C.F.: On r-circulant matrices with Fibonacci and Lucas numbers having arithmetic indices, AIP Conf. Proc. 1905 (2017), 030010] is improved because this result can not be applied in some cases. Since Theorem 4 in the same work relies on Theorem 2, the obtained formulae for the eigenvalues of a k-circulant matrix involving the Lucas numbers of even index show that there are cases when the result of Theorem 4 can also not be applied. Additionally, we present a more precise formula for the Euclidean norm of such matrix compared to the formula presented in Theorem 5 in the aforementioned reference. The upper and lower bounds for the spectral norm of a k-circulant matrix whose first row is

(

L

2

−
1

,

L

4

−
1

,
…
,

L

2
n

−
1

)

$(L_{2}^{-1},L_{4}^{-1},\dots,L_{2n}^{-1})$

are also investigated. The obtained results are illustrated by examples.
Convergence of α-Bernstein-Durrmeyer operators about a collection of measures
Authors: Kaur Harmanjit , Goyal Meenu Rani 
Published: February 2025

Abstract
This work offers a generalization of the α-Bernstein-Durrmeyer operators

D

m
,

Z

α

$\mathfrak{D}^{\alpha}_{m,\mathbf{Z}}$

about a collection Z of arbitrary measures, with the goal of building a bridge between approximation, probability, and measure theory. It has been discussed how to achieve pointwise convergence of

D

m
,

Z

α

$\mathfrak{D}^{\alpha}_{m,\mathbf{Z}}$

and constraints on measure collection have been developed for these operators’ convergence. With certain values of the measures considered, the generalization yields a range of Bernstein-like operators with their α variation. In order to handle a wider variety of p.l.o. and investigate their convergence, the paper comprises numerous operators, making it a useful tool.
Comparison of topologies on fundamental groups with subgroup topology viewpoint
Authors: Shahami Naghmeh , Mashayekhy Behrooz 
Published: February 2025

Abstract
In order to make the fundamental group (one of the most well-known invariants in algebraic topology) more useful and powerful, some researchers have introduced and studied various topologies on the fundamental group from the beginning of the 21st century onwards. In this paper, first we recall and review these topologies and then using the concept of subgroup topology, we compare these topologies in order to present some results on topologized fundamental groups.