bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudolaric acid B triggers ferritinophagy and ferroptosis via upregulating NCOA4 in lung adenocarcinoma cells
Authors: Miao Yu’e , Yin Qiao , Ping Lifeng , Sheng Huan , Chang Jin , Li Wentong , Lv Shijun 
Published: December 2023

Background:
Ferroptosis is a novel subtype of programmed cell death caused by iron-dependent lipid peroxidation and excessive reactive oxygen species (ROS) production. Small-molecule ferroptotic drugs have the probability of selectively targeting the specific features of aggressive tumor cells. In particular, pseudolaric acid B (PAB) triggered ferroptosisin breast cancer cells. The aim of this study is to explore the antitumor effect of PAB on A549 cells and provide a theoretical basis for the further development and clinical application of PAB.

Methods:
First, relevant databases were used to predict of target genes related to PAB, Then, EdU proliferation assay, colony formation and wound-healing assays were applied to calculate A549 cells proliferative abilities. Measurement of ferrous iron, lipid peroxidation, ROS, malondialdehyde (MDA) and glutathione (GSH) were utilized to explore the relevant mechanism.

Results:
We showed that PAB decreased the viability of lung adenocarcinoma cells in vitro, which was accompanied by abnormally elevated levels of intracellular ferrous iron and overproduction of lipid reactive oxidate species (L-ROS). In turn, deferoxamine (DFO) significantly rescued PAB-induced lipid peroxidation. PAB also improved the intracellular labile iron pool by promoting ferritin autophagy via the upregulation of the nuclear receptor coactivator 4 (NCOA4). Moreover, silencing of NCOA4 alleviated PAB-inducedferroptotic death and reduced the levels of intracellular ferrous iron.

Conclusions:
In summary, PAB-triggered ferroptosis in lung adenocarcinoma cells by enhancing ferritinophagy. thus, PAB is a potential therapeutic agent for lung adenocarcinoma.
Development and Validation of Brief Family Intervention for Young Adults with Substance Use Disorder: A Qualitative Study
Authors: Binumon Kodikuthiyel Vijayan , Ezhumalai Sinu , Janardhana Navaneetham , Chand Prabhat Kumar 
Published: December 2023

Abstract

Background:
Substance abuse is more prevalent in young adults, putting them at risk for chronic use and early onset of dependence on substances. A well-documented relationship exists between substance use and poor family functioning. Traditional family intervention approaches are time-consuming.

Aim:
To develop a brief family intervention for parents of young adults with substance use disorder.

Methods:
A qualitative research design was used. Extensive literature searches and key informant interviews (face to face) with young adults (n = 5), their parents (n = 5), and mental health professionals (n = 5) were conducted. The interviews were audio recorded. A thematic analysis was conducted using Braun and Clarke’s six-step approach, and intervention strategies were identified by examining the themes. In addition, experts were consulted to ensure the content validity of the BFI.

Results:
The BFI program combines psychoeducation and behavioral techniques for parents. BFI involves seven sessions with parents, 45–60 min each, over one week. The BFI sessions consisted of (1) Engagement and Assessment, (2) Healthy Family Functioning, (3) Psychoeducation, (4) Relapse Prevention, (5) Communication Skill Training, (6) Problem-Solving Skill Training, and (7) Parental Monitoring and Supervision.

Conclusion:
Considering all stakeholders’ perspectives, the BFI manual for young adults with substance use disorder has been developed. However, additional research is required to evaluate its feasibility and effectiveness.
Prevalence and Risk Factors of Postmicturition Dribble in Men
Authors: Liu Shih-Ping , Ko Po-Wei , Ho Chen-Hsun 
Published: December 2023

Abstract

Purpose:
We investigated postmicturition dribble (PMD) prevalence rates and risk factors in men.

Materials and Methods:
This cross-sectional study included 1037 men aged 31–86 years who participated in a male health survey. PMD was defined by involuntary urine loss immediately after urine was passed and was scaled from 0 to 5, depending on symptom severity. A score of ≥3 was considered significant PMD. PMD prevalence was also determined by age group, and logistic regression analyses were performed to identify risk factors.

Results:
The mean age of participants was 55.3 ± 8.9 years. Overall, 232 (22.4%) reported significant PMD. PMD prevalence significantly increased with age (P = 0.013): it was 18.2%, 17.2%, 20.8%, 28.7%, and 30.1% in men aged 30–39, 40–49, 50–59, 60–69, and ≥70 years old, respectively. Univariate analyses revealed that age, peak flow rate (Qmax), and prostate specific antigen levels were associated with significant PMD, while in multivariate analyses, only decreased Qmax was an independent risk factor.

Conclusion:
PMD was identified as a common condition in men across all age groups, and its prevalence significantly increased with age. The condition correlated more with voiding symptoms when compared with storage symptoms, and was associated with decreased Qmax.
The world of graphics by Dagdangijn Amgalan
Authors: Сарантуяа Б. 
Published: December 2023

В статье рассматриваются графические произведения выдающегося монгольского художника Дагдангийна Амгалана (1933–2009). Впервые в научной литературе ставится вопрос об особом значении графики в его творчестве и анализируются основные произведения, относящиеся к данному виду искусства. Основное внимание уделено трем выполненным им сериям линогравюр — «Социалистический Улан-Батор» (1961), «Утро моей родины» (1962) и «Рождение человека» (1966). В качестве основной исследовательской задачи поставлены вопросы о том, каким образом выстраиваются связи между отдельными графическими листами внутри каждой серии и какими выразительными средствами пользовался художник. Делается вывод об эволюции на протяжении 1960-х годов изобразительной стилистики и художественных приемов организации рассказа, использованных Амгаланом. В статье показано, что графика служила для него в качестве области художественного эксперимента, где формировались стилистические решения, впоследствии применявшиеся в других видах искусства.
This article deals with the investigation of graphic works by an outstanding Mongolian artist Dagdangijn Amgalan (1933–2009). For the first time in the historiography of Mongolian art, we explore the specific position of the drawing art in his artistic output studying his main artworks in this specific medium. In the focus of our attention, there are three graphic series produced by Amgalan — “Socialist Ulaanbaatar” (1961), “My Land’s Morning” (1962), and “Birth of a Human Being” (1966). The main goal of this research consists in exploring the principles of reciprocal interconnections between different pieces within the framework of each series as well as expressive means used by the Mongolian artist. Given this, we are trying to demonstrate how Amgalan’s graphic style and narrative principles had been developing during the course of the 1960s. It was proved that Amgalan’s graphic art served for him as a kind of the testing laboratory for experimenting with different stylistic forms which, in their turn, consequently had been employed in other spheres of Amgalan’s prolific artistic activity.
The artistic work of M.N. Rudnev in relation to the influence of his teacher A.P. Levitin
Authors: Татьяна В.И. 
Published: December 2023

Статья раскрывает некоторые аспекты педагогической деятельности, сложившиеся в творческой мастерской живописи Регионального отделения Урала, Сибири и Дальнего Востока Российской академии художеств в г. Красноярске под руководством академика АХ СССР А.П. Левитина. Кратко представлены основные этапы жизненного и творческого пути художника и педагога, выявлены особенности педагогического метода, и прослеживается, как они способствовали формированию молодых художников. В качестве примера рассматривается творчество Максима Николаевича Руднева, которое еще не получило основательного искусствоведческого описания и анализа. В статье представлен путь становления художника, выделены основные темы произведений. На основе сравнительного анализа ряда работ А.П. Левитина и М.Н. Руднева показана их принадлежность к реалистическому направлению в живописи, стремление с максимальной полнотой раскрыть психологический мир героев в портретах и сюжетных картинах. В искусстве Руднева отмечено тяготение к обобщению в пластическом решении произведения, а также к символичности в идейно-сюжетном плане.
The article reveals some aspects of pedagogical activity that took place in the creative painting workshop of the Regional Department of the Urals, Siberia and the Far East of the Russian Academy of Arts in Krasnoyarsk. The workshop was led by the Academician of the Academy of Arts of the USSR A.P. Levitin. The article briefly presents the main stages of the life and creative path of the artist and teacher, and reveals the peculiarities of his pedagogical method. It also traces how these contributed to the formation of young artists. The work of Maksim Nikolayevich Rudnev, as it has not yet received a thorough art history description and analysis, is considered as an example. The article highlights the artist's formation and the main themes of his works. Based on a comparative analysis of works by A.P. Levitin and M.N. Rudnev, it is demonstrated that they belong to the realistic direction in painting and aim to fully reveal the psychological world of their subjects in portraits and narrative paintings. Rudnev's art tends towards generalisation in the plastic solution of the work, as well as symbolism in the ideological and plot plan.
Optimalisasi PAD: Mengungkap Potensi dan Kontribusi Pajak Mineral Bukan Logam dan Batuan Melalui Analisis Trend
Authors: Anita Rossy Dwi , Lubis Firsty Ramadhona Amalia , Yunizarrahman Yunizarrahman 
Published: December 2023

Abstrak: Penelitian ini menggunakan metode kuantitatif dengan pendekatan deskriptif dan menganalisis potensi serta kontribusi pajak tersebut terhadap PAD. Analisis trend digunakan untuk meramalkan kondisi masa yang akan datang. Hasil penelitian diharapkan dapat memberikan rekomendasi program dan kebijakan untuk mengoptimalkan PAD melalui pajak tersebut. Realisasi pajak mineral bukan logam dan batuan Kabupaten Gunungkidul dari tahun 2013-2022 telah melampaui target dengan nilai diatas 100 persen, kecuali pada tahun 2022. Penurunan realisasi pajak pada tahun 2022 disebabkan oleh penutupan permanen oleh penambang dan adanya tambahan pungutan yang kewenangannya ada di provinsi. Analisis trend menunjukkan potensi kenaikan realisasi pajak untuk tahun-tahun mendatang. Kontribusi pajak mineral bukan logam dan batuan terhadap PAD menunjukkan fluktuasi, namun masih memiliki potensi untuk mengoptimalkan realisasi pajak tersebut. Optimalisasi pendapatan daerah melalui pajak mineral bukan logam dan batuan dapat dilakukan melalui beberapa langkah, seperti penilaian yang akurat terkait volume, kualitas, dan nilai ekonomis sumber daya, kebijakan pajak yang mendukung, pembangunan infrastruktur, investasi dalam pendidikan dan pelatihan, serta membangun kemitraan dengan pihak swasta.

Abstract: This research uses a quantitative method with a descriptive approach and analyzes the potential and contribution of these taxes to PAD. Trend analysis is used to forecast future conditions. The results of the study are expected to provide recommendations for programs and policies to optimize PAD through these taxes. The realization of non-metal mineral and rock taxes in Gunungkidul Regency from 2013-2022 has exceeded the target with a value above 100 percent, except in 2022. The decrease in tax realization in 2022 was caused by permanent closure by miners and additional levies whose authority is in the province. Trend analysis shows potential increases in tax realization for future years. The contribution of non-metallic mineral and rock tax to PAD shows fluctuations, but still has the potential to optimize the realization of the tax. Optimization of local revenue through non-metallic mineral and rock taxes can be done through several steps, such as accurate assessment of the volume, quality and economic value of resources, supportive tax policies, infrastructure development, investment in education and training, and building partnerships with the private sector.
Cierre de parafuga valvular con dispositivos off - label: un recurso valioso
Authors: Herrera Emilio , Navarro Alberto , Vanegas Julián , Ortiz Juan C 
Published: December 2023

Se presenta el caso de un paciente con parafuga valvular de prótesis mecánica en posición aórtica. Por intervención quirúrgica previa reciente se decide llevar a reparo percutáneo para disminuir riesgo perioperatorio, bajo indicación no aprobada (off label) usando un dispositivo para cierre de comunicación interventricular, exitoso y sin complicaciones en el seguimiento.
Yapay zeka uygulamalarının sağlık sektöründe kullanımı: Derin öğrenme yöntemiyle ön tanı
Authors: YENİKAYA Muhammed Akif , OKTAYSOY Onur 
Published: December 2023

Amaç: Bilgi çağı olarak adlandırılan günümüz dünyasında dijitalleşme her sektörde olduğu gibi sağlık sektöründe de kendisine önemli bir yer edinmiştir. Özellikle yapay zekâ teknolojilerinin sağlık sektörü üzerinde muazzam denilebilecek bir değişim etkisi sözkonusudur. Tanı ve teşhis yapabilmenin yanı sıra, sektörde yer alan nitelikli insan kaynağına alternatif olabilmesi beklenen yapay
zekâ, bu araştırma da alt kümeleri olan derin öğrenme ağları perspektifinden ele alınmıştır. Çalışmada derin öğrenme ağlarından olan ResNet101 ve GoogLeNet bağlamında yapay zekânın hastalık teşhisindeki başarı düzeyinin belirlenmesi amaçlanmaktadır.

Yöntem: Araştırma amacı doğrultusunda açık erişimli Kaggle web sitesinden beyin tümörü türlerinden olan Glioma, Meningioma ve Pituitary içeren toplamda 2124 adet MR görüntü veri seti elde edilmiş, bu verilerle %70 eğitim, %30 test oranı ile araştırmada kullanılan derin öğrenme ağlarının, görüntü ayrıştırma ve tanımlama başarı düzeyleri karşılaştırılmıştır.

Bulgular: Analiz bulguları derin öğrenme ağlarının üç farklı beyin tümörü hastalığını ayrıştırma ve tanımlama noktasında başarılı olduğunu göstermiştir. Derin öğrenme ağlarının başarı düzeyleri incelendiğinde ResNet101 derin öğrenme ağının %91.5, GoogLeNet derin öğrenme ağının ise %87.9 başarı düzeyine sahip olduğu tespit edilmiştir.

Sonuç: Araştırmanın bulguları doğrultusunda ResNet101 ve GoogLeNet derin öğrenme ağlarının beyin tümörü türlerini tanımlama ve ayrıştırma noktasında kullanılabilir olduğu, ResNet101 derin öğrenme ağının araştırma özelinde daha yüksek başarı oranı kaydettiği ve son olarak yapay zekâ teknolojilerinin sağlık sektöründe önemli bir yer edinme potansiyelinin olduğu tespit edilmiştir.
INFLUENCE OF CORRUPTION FACTORS ON THE DEVELOPMENT OF THE ASIAN STOCK MARKET
Authors: Мясоедов А.И. , Иванова С.П. 
Published: December 2023

Фондовый рынок играет значительную роль в корпоративном финансировании. Однако на движение фондового рынка в значительной степени повлияли некоторые внешние факторы, такие как экономические, психологические и политические факторы. Используя выборку из 10 азиатских стран, данное исследование направлено на изучение влияния макроэкономических и коррупционных факторов на развитие фондового рынка. Зависимой переменной, использованной в этом исследовании, было развитие фондового рынка. В то время как переменными интереса, использованными в этом исследовании, были 1) уровень дохода; 2) сбережения; 3) прямые иностранные инвестиции; 4) стоимость торгуемых акций; 5) денежная масса; 6) индекс восприятия коррупции. При проверке взаимосвязи между переменными, обусловленной характером данных, был применен подход, основанный на панельных данных. Как и ожидалось, валовые внутренние сбережения, прямые иностранные инвестиции и денежная масса оказались в значительной степени связаны с развитием фондового рынка. С другой стороны, уровень доходов, как оказалось, имеет значительную негативную связь с развитием фондового рынка. Примечательно, что результаты также показали, что снижение уровня коррупции может привести к росту развития фондового рынка. Таким образом, изменение уровня коррупции является важным вопросом, который необходимо рассмотреть до принятия любого инвестиционного решения, поскольку уровень коррупции оказывает значительное влияние на развитие фондового рынка.
The stock market plays a significant role in corporate finance. However, the stock market movement was largely influenced by some external factors, such as economic, psychological and political factors. Using a sample of 10 Asian countries, this study aims to study the impact of macroeconomic and corruption factors on the development of the stock market. The dependent variable used in this study was the development of the stock market. While the variables of interest used in this study were 1) income level, 2) savings, 3) foreign direct investment, 4) value of traded shares, 5) money supply and 6) corruption perception index. When checking the relationship between variables due to the nature of the data, a panel-based approach was applied. As expected, gross domestic savings, foreign direct investment and money supply were largely associated with the development of the stock market. On the other hand, the level of income, as it turned out, has a significant negative relationship with the development of the stock market. It is noteworthy that the results also showed that a decrease in the level of corruption can lead to an increase in the development of the stock market. Thus, changing the level of corruption is an important issue that needs to be considered before making any investment decision, since the level of corruption has a significant impact on the development of the stock market.
WAYS TO IMPROVE THE LEGAL REGULATION OF CONFISCATION OF PROPERTY IN THE PRISM OF LEGAL TECHNIQUE
Authors: Наурбиева Ф.Х. 
Published: December 2023

В данной статье автором проводится компаративистский анализ состояния конфискации имущества в отечественном уголовном праве, а также в уголовном праве зарубежных стран в призме юридико-технического аспекта. Выделяются положительные моменты, оптативно подлежащие рецепции в законодательство Российской Федерации. Указывается на недостатки законодательной техники в вопросе института конфискации имущества, приводятся в этом ключе решения правоприменителя (при наличии), а также представителей доктрины. Определяются резервы для оптимизации регламентации искомого института права и предлагаются пути решения.
In this article the author carries out a comparativist analysis of the state of confiscation of property in domestic criminal law, as well as in the criminal law of foreign countries in the prism of legal and technical aspect. Positive moments, optatively subject to prescription in the current legislation of the Russian Federation are emphasized. It is pointed out the shortcomings of legislative technique in the issue of the institute of confiscation of property, the decisions of law enforcement (if any), as well as representatives of the doctrine are given in this regard. The reserves for optimization of regulation of the sought institute of law are determined and the ways of solution are offered.
GROUNDS AND CONDITIONS FOR BRINGING A CONTROLLING DEBTOR TO SUBSIDIARY LIABILITY IN BANKRUPTCY
Authors: Незнамова А.А. 
Published: December 2023

В статье проанализированы основания привлечения к субсидиарной ответственности контролирующего должника лица при банкротстве. Рассмотрена совокупность условий, необходимых для привлечения к субсидиарной ответственности контролирующих должника лиц. Выявлено, что в последние несколько лет судами Российской Федерации были приняты значимые решения, оказывающие влияние на формирование судебной практики. В связи с чем автором сделан ряд выводов в том числе о том, суд может признать лицо контролирующим должника по различным признакам или по совокупности различных критериев. Также определено, что в настоящее время имеются тенденции, направленные на отказ от формального подхода к определению контролирующих должника лиц. Выработана авторская позиция по исследуемому вопросу.
The article analyzes the grounds for holding a controlling debtor liable for subsidiary liability in case of bankruptcy. Consideration has been given to the aggregate of the conditions necessary to hold controlling persons liable for subsidiary liability, and it has been discovered that in the past few years the courts of the Russian Federation have adopted significant decisions affecting the formation of court practice. In connection with this, a number of conclusions were reached, including that a court may recognize a person as controlling a debtor on various grounds, based on a set of different criteria. It has also been determined that there are currently trends aimed at withdrawing from the formal approach to determining the controlling debtor. The author’s position on the issue under review was developed.
Analisis Strategi Pengembangan Pemasaran Produk Java Coffee Tlogo pada Perkebunan Tlogo Tuntang Kabupaten Semarang
Authors: Kustopo Budiraharjo, dan Wiludjeng Roessali Devinta Ayuningtyas, 
Published: December 2023

Agroindustri kopi memiliki peluang yang cukup besar untuk dikembangkan di Indonesia karena memiliki prospek besar baik nasional maupun internasional. Penelitian ini bertujuan untuk menganalisis faktor internal dan eksternal serta merumuskan strategi prioritas yang tepat untuk pengembangan pemasaran produk Java Coffee Tlogo pada Perkebunan Tlogo Tuntang di Kabupaten Semarang. Metode penelitian yang digunakan adalah studi kasus dengan wawancara pengisian kuesioner oleh key informant dari internal dan eksternal perusahaan. Data dianalisis dengan menggunakan analisis SWOT dan Analytical Hierarchy Process (AHP) menggunakan SuperDecisions. Hasil penelitian menunjukkan bahwa posisi perusahaan terletak pada Kuadran I, sehingga strategi SO (Strength-Opportunity) yang diterapkan adalah mengoptimalkan pemanfaatan lahan perkebunan dan dukungan pemerintah serta organisasi terkait untuk meningkatkan produksi kopi, memanfaatkan keunggulan kualitas dan rasa kopi untuk memperkenalkan Java Coffee Tlogo pada pasar yang lebih luas, dan memperkuat merek Java Coffee Tlogo dengan memanfaatkan lokasi sebagai tempat wisata dan edukasi tentang kopi. Prioritas strategi utama adalah memanfaatkan keunggulan kualitas kopi untuk memperkenalkan Java Coffee Tlogo pada pasar yang lebih luas dengan meningkatkan promosi produk secara tidak langsung.
Parametric Poisson Bifurcated Autoregressive Process: Application to Worldwide, Regional, and Peculiar Countries’ of Automobile Production
Authors: Olanrewaju Rasaki Olawale , Olanrewaju Sodiq Adejare , Oguntola Toyin Omoyeni , Adepoju Wasiu 
Published: December 2023

This article introduces Bifurcated Autoregressive (BAR) process with two apart marginal distribution error terms of w2 and w2+1 of Poisson white noises to make it Poisson Bifurcated Autoregressive (PBAR) in a parametric setting. The statistical definition of PBAR (1) process with parameters B1 and B2 that must be |B1 | and |B2 |<1 for stationary process was spelt-out. Weighted Least Squares (WLS) parameter estimation technique was adopted and the process limiting distribution was carried-out via the combination methods of martingale process and Lindeberg’s condition. Monthly automobile production in Japan, Outside Japan, America, USA, Europe, Asia, and China that approximately tantamount to worldwide, regional, and peculiar countries’ of automobile production was subjected to the PBAR process. In conclusion, Japan automobile production possessed the highest and largest error correlation (w2 , w2+1 ) of 0.6582 (65%) with first order PBAR, with B1Y(t/2) , such that B1=0.2228 of degenerated two major divisions of automobile production of Registrations and Mini-Vehicles with descendant of different brands (models).