bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR‐23a‐3p alleviates cigarette smoke extract‐induced pulmonary vascular endothelial cell apoptosis by targeting DNAJB1 in emphysema
Authors: Li Ke , Ye Xianwei , Xu Mei , Xu Chuan , Lu Ping , Li Jiayi , Yuan Guohang , Zhang Cheng 
Published: October 2023

AbstractBackgroundCigarette smoke (CS) is an important risk factor for chronic obstructive pulmonary disease, including emphysema. MicroRNAs (miRNAs) are important regulators of emphysema progression. However, miR‐23a‐3p role in emphysema is unclear.MethodsCS exposure was used to construct emphysema mice models, and cigarette smoke extract (CSE)‐induced pulmonary vascular endothelial cells (PMVECs) were used to mimic emphysema cell models. Mouse lung tissue was stained by immunohistochemical staining, hematoxylin and eosin staining, and TUNEL staining. MiR‐23a‐3p and DnaJ homolog subfamily B member 1 (DNAJB1) levels were tested using quantitative real‐time PCR. DNAJB1 and apoptosis‐related markers' protein levels were examined via western blot analysis. Cell viability and apoptosis were analyzed by MTT assay and flow cytometry. The interaction between miR‐23a‐3p and DNAJB1 was evaluated by dual‐luciferase reporter assay and RIP assay.ResultsMiR‐23a‐3p was downregulated, and DNAJB1 was upregulated in CS‐induced emphysema mice models and CSE‐induced PMVECs. MiR‐23a‐3p overexpression promoted viability and repressed apoptosis in CSE‐induced PMVECs. MiR‐23a‐3p targeted DNAJB1 and negatively regulated DNAJB1 expression. Moreover, DNAJB1 knockdown repressed CSE‐induced PMVECs apoptosis, and miR‐23a‐3p inhibitor reversed this effect. Additionally, miR‐23a‐3p alleviated lung tissue injury and improved emphysema in mice by reducing DNAJB1 expression.ConclusionMiR‐23a‐3p alleviated emphysema progression, which could inhibit CSE‐induced PMVECs apoptosis by targeting DNAJB1.
A review of factors influencing drinking behaviours in young Australian adults using a behavioural framework approach
Authors: Palmer Blake , Irwin Christopher , Desbrow Ben 
Published: October 2023

AbstractIssuesYoung adults (aged 18–24 years) are more likely to binge drink than any other age group in Australia. These behaviours expose young adults to possible adverse events, with potential for acute harms.ApproachA behavioural framework (capability, opportunity, motivation—behaviour [COM‐B model]) was used to explore factors that influence the drinking behaviours of young Australian adults. Potential studies were identified by searching four online data bases. Content pertaining to factors moderating young adults' alcohol consumption behaviours (either increasing or decreasing alcohol consumption) in an Australian population was extracted. Factors were then categorised/mapped into the six sub‐components of the COM‐B model. A narrative synthesis/discussion was subsequently undertaken.Key FindingsFactors increasing or reducing alcohol consumption behaviours were identified across all components of the COM‐B model. Overall, alcohol consumption behaviours appear strongly influenced by physical and social opportunities, and young adults have reflective and automatic motivations (i.e., habitual processes, emotional responding and analytical decisional making that directs behaviour) to consume alcohol with purpose and/or reason.Implications and ConclusionThe use of a behavioural framework (e.g., the COM‐B model) facilitates an integrated understanding of factors influencing alcohol consumption behaviours. Future harm minimisation strategies need to consider the interrelated, contemporary factors underpinning a young adult's decision to consume alcohol within the context of modern Australian society.
Time trends towards earlier puberty in boys and girls with type 1 diabetes: Insights from the German Diabetes Prospective Follow‐up (DPV) registry, 2000 to 2021
Authors: Gohlke Bettina , Reschke Felix , Lanzinger Stefanie , Boettcher Claudia , Gemulla Gitta , Thiele‐Schmitz Susanne , Dunstheimer Désirée , van den Boom Louise , Woelfle Joachim , Holl Reinhard W. 
Published: October 2023

AbstractAimTo examine the time trends and factors associated with the onset of puberty in children with type 1 diabetes (T1D) using data from the German Diabetes Prospective Follow‐up (Diabetes‐Patienten‐Verlaufsdokumentation [DPV]) registry.MethodsA total of 13 127 children with T1D, aged 6 to 18 years, were included in the analysis. Regression analysis was performed to investigate the relationship between diabetes duration, body mass index (BMI) standard deviation score (SDS), glycated haemoglobin (HbA1c) level, migration background, and the onset of puberty, stratified by sex.ResultsOur findings revealed a significant trend towards earlier puberty in both girls and boys with T1D over the observed period (2000 to 2021). Puberty onset in girls (thelarche Tanner stage B2) decreased from 11.48 (11.35‐11.65) years in 2000 to 10.93 (10.79‐11.08) years in 2021 and gonadarche (Tanner stage G2/testicular volume >3 mL) decreased from 12.62 (12.42‐12.82) years in 2000 to 11.98 (11.79‐12.16) years in 2021 in boys (both P < 0.001). Longer diabetes duration, higher BMI SDS, and lower HbA1c level were associated with earlier puberty in both sexes (P < 0.001).ConclusionsOur study highlights earlier puberty in children with T1D, influenced by BMI SDS, HbA1c level, and migration background. This has important implications for diabetes management and supporting healthy development. Further research is needed to understand the underlying mechanisms and develop potential interventions for this vulnerable population.
Approach for the probabilistic fatigue assessment of welded joints based on the local geometry of the weld seam
Authors: Schubnell Jan , Konidena Sai Kumar , Jung Matthias , Braun Moritz , Ehlers Sören , Madia Mauro , Kannengießer Thomas , Löschner Daniel 
Published: October 2023

AbstractWelded joints show large variation of the weld toe geometry along the weld seam, which is one important reason for the comparably large scatter in fatigue life. Therefore, it is crucial to take the local geometry at the weld toe into account, to reduce the conservatism in fatigue assessment of welded joints. This study is based on the IBESS procedure for the calculation of the fatigue strength, whereby the evaluation of local geometrical parameters is carried out by means of 3D surface scans. The approach is validated against 26 fatigue test series. The fatigue life is in general overpredicted, whereas good agreement is achieved for high stress ratio (
). A sensitivity analysis conducted with IBESS shows that weld toe radii ρ < 2 mm and flank angle α < 30° have a significant influence on the calculated fatigue strength. In contrast to this, no strong correlation between
and the fatigue strength was determined experimentally in this study.
Fungal necromass is reduced by intensive drought in subsoil but not in topsoil
Authors: Liu Yuwei , Zou Xiaoming , Chen Han Y. H. , Delgado‐Baquerizo Manuel , Wang Cuiting , Zhang Chen , Ruan Honghua 
Published: October 2023

AbstractThe frequency and intensity of droughts worldwide are challenging the conservation of soil organic carbon (SOC) pool. Microbial necromass is a key component of SOC, but how it responds to drought at specific soil depths remains largely unknown. Here, we conducted a 3‐year field experiment in a forest plantation to investigate the impacts of drought intensities under three treatments (ambient control [CK], moderate drought [30% throughfall removal], and intensive drought [50% throughfall removal]) on soil microbial necromass pools (i.e., bacterial necromass carbon, fungal necromass carbon, and total microbial necromass carbon). We showed that the effects of drought on microbial necromass depended on microbial groups, soil depth, and drought intensity. While moderate drought increased total (+9.1% ± 3.3%) and fungal (+13.5% ± 4.9%) necromass carbon in the topsoil layer (0–15 cm), intensive drought reduced total (−31.6% ± 3.7%) and fungal (−43.6% ± 4.0%) necromass in the subsoil layer (15–30 cm). In contrast, both drought treatments significantly increased the BNC in the topsoil and subsoil. Our results suggested that the effects of drought on the microbial necromass of the subsoil were more pronounced than those of the topsoil. This study highlights the complex responses of microbial necromass to drought events depending on microbial community structure, drought intensity and soil depth with global implications when forecasting carbon cycling under climate change.
Effect of dextran and concentrated fructose from Weissella cibaria in the physicochemical and sensory properties of milk bread (pan de leche), gelato and calamansi (Citrus microcarpa) juice
Authors: Castro Ian John L. , Rivera Arrjay Mar B. , Kim Myunghee , Guce‐Bigol Ursela P. 
Published: October 2023

SummaryAn exopolysaccharide‐producing isolate, Weissella cibaria ITDI 0199, was investigated to determine its ability to produce dextran and fructose, and its applicability to various food products. The isolate was cultivated in a fermentation medium of sucrose‐enriched coconut water waste obtained from a virgin coconut oil‐producing plant. Dextran produced from W. cibaria ITDI 0199 was processed by spray‐drying with maltodextrin and was incorporated into milk bread and gelato ice cream. At the same time, concentrated fructose was utilised as a partial substitute ingredient for ready‐to‐drink (RTD) calamansi (Citrus microcarpa) juice. Incorporating spray‐dried dextran into bread showed reduced cooking time, possible lower labour, and mechanical input costs, while the gelato products exhibited an increase in viscosity and thickness of ice cream mixture, leading to a decrease in ice cream melting rate when exposed at room temperature (25 °C). Additionally, using fructose as a sweetener in the calamansi juice reduced dependence on sugar. It has increased the dilution factor of the final product, potentially leading to increased profits.
Understanding ‘value’ in the context of community‐based interventions for people affected by dementia: A concept analysis
Authors: Stephens Nathan , Evans Shirley , Russell Chris , Brooker Dawn 
Published: October 2023

AbstractAimThis study aimed to conduct a concept analysis of value in the context of community‐based interventions for people affected by dementia.BackgroundConcepts of value play a critical role in shaping the delivery and distribution of community‐based health interventions through related concepts. However, the use and meaning of ‘value’ is rarely clarified limiting the term's utility in practice and research. Increasing need for community healthcare and scarce public resources means developing understanding of value in community‐based interventions for people affected by dementia is timely, and may support more informed approaches to exploring, explaining and delivering value.DesignEvolutionary Concept Analysis was used to systematically determine the characteristics of value.Data SourcesPeer‐reviewed and grey literature databases were searched between April and July 2021, with 32 pieces of literature from different disciplines included in the final sample. No limits were set for the years of literature retrieved.MethodsLiterature was thematically analysed for information on the antecedents, attributes and consequences of value.Results and DiscussionThe analysis uncovered a need and/or desire to understand the experience of people affected by or that affect interventions; and to demonstrate, prove/disprove the (best) quality and nature of results of interventions as antecedents of value. Attributes of value were stakeholder/person centred, measurable, time and context dependent and multidimensional. Consequences of the concept included shared decision‐making, valuation of interventions and internal/external investment and development of interventions.ConclusionThrough concept analysis value can now be better understood and applied. The development of a conceptual model to illustrate the constituent elements and relationships of the concept adds transparency to where, why and how concepts of value are enabled that supports future concept development.Patient and Public ContributionNo patient or public contribution.
Association of age at menarche with gestational hypertension and preeclampsia: A large prospective cohort in China
Authors: An Hang , Liu Xiaojing , Li Zhiwen , Zhang Le , Zhang Yali , Liu Jianmeng , Ye Rongwei , Li Nan 
Published: October 2023

AbstractThis study explored the potential association between age at menarche and the risks of gestational hypertension and preeclampsia in Chinese women. Data were sourced from the China‐US Collaborative Project for Neural Tube Defects Prevention, a large population‐based cohort study. Our study consisted of 209 411 women pre‐registered for pregnancy in two provinces in South China. Trained healthcare workers measured blood pressure at registration and recorded other pertinent health information. Using logistic regression, we assessed the correlations between age at menarche and the likelihood of developing gestational hypertension and preeclampsia, considering confounders such as maternal age, body mass index, ethnicity, parity, folic acid supplementation, education level, and occupation. The observed incidences for gestational hypertension and preeclampsia were 9.65% and 2.54%, respectively. The adjusted odds ratios (ORs) for gestational hypertension, based on age at menarche, were as follows: ≤13 years, 1.18 (95% confidence interval: 1.11–1.26); 14 years, 1.09 (1.04–1.15); 15 years, 1.11 (1.06–1.16); 16 years, 1.06 (1.01–1.12); and ≥17 years, 1.00 (reference; P for trend < .001). The correlation between age at menarche and preeclampsia varied across age groups, with the following respective ORs: 1.35 (1.20–1.52), 1.21 (1.09–1.34), 1.27 (1.15–1.39), 1.14 (1.03–1.26), and 1.00 (reference; P for trend < .001). This association appeared to be more pronounced in women with no folic acid supplementation and those with a lower education level. In conclusion, an earlier age at menarche seems to be linked to increased risks of gestational hypertension and preeclampsia.
The effects of price transparency and debt collection policies on intentions to consume recommended health care: A randomized vignette experiment
Authors: Robertson Christopher T. , Epstein Wendy Netter , Ko Hansoo 
Published: October 2023

AbstractNew laws promote price transparency in health care, though effects on patient decision‐making are not known. Price disclosure may increase the salience of cost and cause lower‐income patients to decline recommended care, worsening inequities in health outcomes. Whether patients perceive a disclosed cost as higher or lower than their expectations may also affect care decisions, but has not been studied. Scholars and policymakers have paid much less attention to the question of whether patients will have to pay the prices charged (whether disclosed or not), and how expectations regarding collections may also affect healthcare consumption. Some hospitals aggressively collect on unpaid medical bills. Others hospitals do not. Actively disclosing collection policies (whether aggressive or protective) could magnify or counteract effects of price disclosures, especially for low‐income patients. To test the effect of price disclosure and debt‐collection disclosures on willingness to obtain recommended care, we recruited a nationally representative sample (N = 2997) and deployed a full factorial, controlled experiment in a standardized clinical vignette model. We find that disclosing a higher‐than‐anticipated price increases the probability of declining recommended care (odds ratio = 1.900), with larger effects for low‐income individuals. Even more, disclosing aggressive collections increases the risk of declining care (odds ratio = 4.493), at higher rates for low‐income patients. Where patients fear collections, but do not know prices, they are most likely to decline care. Disclosure of an aggressive collections policy makes patients feel less informed, harms patient trust in providers, makes them feel that they were not treated fairly, and undermines their confidence in the value of their care. Mediation analysis shows that about half of the effect of collections risk is via these attitudinal variables.
Flexible wireless in situ optical sensing system for banana ripening monitoring
Authors: Wang Meng , Zhang Ruihua , Wu Zihao , Xiao Xinqing 
Published: October 2023

AbstractDetermining the ripening level of bananas in the environment of banana ripening plays an important role in ensuring the quality of bananas, reducing losses and waste, and improving economic benefits. Traditional monitoring methods face a series of challenges such as inefficiency, high energy consumption, and high cost. This paper aims to develop a flexible wireless in situ optical sensing system (FIS) for banana ripening monitoring with a good prediction effect, low energy consumption, and high economy. When monitoring the ripening process, the ripeness of the bananas can be accurately determined without taking out the bananas. Among them, the prediction effect on soluble solid content and a* is the best, the residual predictive deviation value is above 3, and the classification accuracy is as high as 95%. Compared to other commercially available spectrometers, the device exhibits the lowest power consumption characteristics. The theoretical maximum energy consumption of the FIS is only 627 mW, and a single measurement only consumes 15 J. The overall price of the FIS does not exceed $60. The application of the FIS can effectively reduce the waste of bananas during the ripening process, and greatly alleviate the labor‐intensive and inefficient problems of fruit maturity monitoring, thereby promoting more sustainable and cleaner production in the banana industry.
Chinese cities exhibit diverse allometric growth patterns in material metabolism
Authors: Yang Mingyue , Liu Ningyin , Wang Xinjing , Zhang Yan 
Published: October 2023

AbstractRapid urbanization boosts the material demand of cities and leads to serious environmental problems, such as water shortage and air pollution. To achieve better governance of cities, stakeholders need to deeply understand urban material utilization. Taking 327 cities in China as examples, this study analyzes the urban material characteristics from a metabolic perspective. We investigated the spatiotemporal changes in the material base of these cities from 2000 to 2020, including material flow and material stock. We further explored the allometric growth patterns of urban material flow and material stock at different scales (e.g., individual, group, and community). Results show that cities have metabolic processes as natural organisms; they differentiate into many types and exhibit allometric growth patterns. There is a consistency of material metabolic patterns in most cities. The growth of material flows (+43%) and material stocks (+135%) was evident in all cities during 2000–2020. However, the material metabolism of Chinese cities exhibits diverse allometric growth patterns across the individual, group, and community scales. This study can provide simple but effective quantitative indicators for the investigation of urban material utilization, and can support distinct policy implications for sustainable urban material‐based planning and management.
Life cycle assessment of pig iron production from bauxite residue: A European case study
Authors: Ma Yan , Pettersen Johan Berg 
Published: October 2023

AbstractLarge volumes of bauxite residue are generated when alumina is leached from bauxite ore, within 2–3 metric tons of bauxite residue per metric ton final aluminum. The large volumes make bauxite residue an interesting source for secondary materials, for instance iron. This paper assesses environmental impacts associated with extraction of pig iron from bauxite residue in Europe. The life cycle assessment is based on thermodynamic process simulation and compares pig iron from bauxite residue with conventional pig iron production. The results indicate that the iron extraction reduces impacts on mineral scarcity and offers an overall lower waste volume. However, it also increases the energy use and thereby the life cycle impacts associated with energy production. The bauxite residue process is operated in an electric arc furnace. Decarbonizing the electricity supply, or placing the process in primarily renewable electricity markets, changes the relative competitiveness of pig iron from bauxite residue, to a level where it offers lower endpoint impacts to ecosystems, human health, and resources, as well as improvements in policy‐relevant midpoint impacts such as climate change. Comparing several bauxite residue mineralogies, the results show significant variation in the environmental performance between typical bauxite residues, yet a larger difference is observed when comparing with conventional pig iron production than among the bauxite residues.
Value relevance of IFRS 9: The influence of country factors and heterogeneous strengths in the European banking sector
Authors: Zampella Annamaria , Ferri Luca 
Published: October 2023

AbstractThis study focuses on investor reactions to financial instrument recognition and measurement in the banking sector under the new International Financial Reporting Standard (IFRS) 9, Financial Instruments. The research tests the combined value relevance of accounting numbers before and after the mandatory transition to IFRS 9 in Europe. Furthermore, we verify the influence of country factors and heterogeneous strengths on the value relevance of the aforementioned standard. To this end, we adopt a sample consisting of 215 banks listed in Europe, for the years 2015–2020. We find a significant change in the explanatory power of value‐relevance regressions in 2015–2017 compared to 2018–2020. In addition, we find that accounting numbers have incremental value relevance in countries characterized by “good” governance indicators and high heterogeneous strength, namely investors pay attention to the strength of the bank authority. This study makes three main contributions to the literature. First, it complements the IFRS 9 literature by providing new evidence. Second, its insights can be used to support investment decisions. Last, the findings help regulators and standard‐setters to verify the impact of the new measures delineated by the standard.