bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving the Automation of Knee Joint Functional Scoring Through Based on Improved YOLOX
Authors: Yang Tao , Zhao Jie , Wang Ben , Wang Li , Bao Hengzhe , Li Bing , Luo Wen , Zhao Huiwen , Liu Jun 
Published: October 2023

Abstract
Objective
This study aims to assess the feasibility of computer model-based evaluation of knee joint functional capacity in comparison to manual assessments.
Methods
The study consists of two phases: (1) developing the automatic knee joint action recognition and classification systems based on improved YOLOX; (2) analyzing the feasibility between the software systems and doctors, identifying knee joint function of patients, and determining the accuracy of the software systems.
Results
In this study, the items of knee joint assessment included the stair climbing, walking on uneven surfaces, and knee joint function in the life. The weighted Kappa coefficients between doctors and the software systems are 0.76180, 0.64148, 0.68792, respectively, indicating good consistency of software systems.
Conclusion
This paper introduces an automatic knee joint action recognition and classification method based on improved YOLOX. Comparing the results between the orthopedic doctors and software system, the effectiveness of this software system is validated.
Patterns of wild edible plants consumption of District Swat, Pakistan: Emphasizing the importance of plants in uplifting the quality of life of local residents
Authors: Ali Shujat , Qurashi Rahmat Ullah , Munazir Mehmooda , Shah Sayed Afzal , Hussain Wahid , Bussmann Rainer W. 
Published: October 2023

Abstract

The people of Swat possess vast knowledge of wild food plants and used as dietary component. There is dire need to document such knowledge because these plants can serve as alternate source of energy, nutrients, minerals, and phytochemicals in a scenario of global food shortages and ever-increasing health problems. The present research is an endeavor to document such data from the Swat district, Pakistan. For this purpose field surveys were carried out during 2018 to 2022 and various growing localities of the region were visited for data collection from knowledgeable locals using semi-structured questionnaire, oral discussions and personal observations. In addition, the available literature on the area 26 was searched to identify novel food plant species. In all, a total 175 plant species belonging to 64 families were identified. The family Rosaceae contributed maximum plant species (19), followed by Fabaceae (15 spp.), Brassicaceae (12 spp.), 28 Rhamnaceae (9 spp.), Lamiaceae (8 spp.), Asteraceae, and Solanaceae (6 spp. each), Polygonaceae and Moraceae (5 spp. each). Fruit was the most widely used part (43%), followed by the shoot (39%), leaves (13%), seeds (10%), pods (5%), and miscellaneous parts (5%). Most of the plants were eaten as fruit (39%), followed by vegetable (37%); while 33% were used for making sauces, curries, flavoring agents, salads, or eaten in raw form. The current study reflected the role of plants as life-sustainers and life-savers for local communities. This research work is expected to provide basis for future research in nutrition science.
The expression of deiodinase 2 and deiodinase 3 are reduced by insulin and D-glucose respectively, in human placental explant cultures
Authors: Herrera-Chavez Nestor , Appel-Rubio Javiera , Rojas Daniela , Mennickent Daniela , Buchert Jorge , Roble Katherine , Sanchez Andrea , Aguayo Claudio , Gonzalez Marcelo , Guzmán-Gutiérrez Enrique 
Published: October 2023

Abstract
Introduction: Gestational diabetes mellitus is associated with altered expression of deiodinases (DIO), a group of seleno-enzymes that metabolize thyroid hormones in several tissues, including human placenta. It has been reported that these alterations could lead to reduced fetal thyroid hormone levels and impaired central nervous system development. However, it is not clear if D-glucose or insulin, which levels are increased in metabolic pathologies such as Gestational diabetes mellitus, are responsible for this phenomenon.
Methods: We recruited 10 women with normal pregnancies from Hospital Guillermo Grant Benavente, Concepcion, Chile. After delivery, explants were extracted from placenta to perform cultures exposed to different concentrations of D-glucose and insulin, in order to evaluate deiodinase mRNA expression by RT-qPCR, enzymatic activity and protein localization by immunohistochemistry.
Results: We observed that insulin could decrease both DIO2 mRNA (~38%) and activity (~40%), and D-glucose diminished DIO3 mRNA (~48%) as well as its activity (~36%). At control conditions DIO2 expression was observed mainly in fetal vasculature, while DIO3 expression focused on macrophage-like cells. D-glucose did not change deiodinase localization in placenta, whereas insulin promoted DIO2 and DIO3 expression in syncytiotrophoblast.
Conclusion: We suggest that a diabetogenic state in pregnancy with high levels of D-glucose and insulin, may lead to deiodinase alterations in placenta and consequently fetal thyroid dysfunction.
WITHDRAWN: Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015
Authors: Depond Charles Champeaux , Zouaoui Sonia , Darlix Amélie , Rigau Valérie , Mathieu-Daudé Hélène , Bauchet Fabienne , Khettab Mohamed , Trétarre Brigitte , Figarella-Branger Dominique , Taillandier Luc , Boetto Julien , Pallud Johan , Zemmoura Ilyess , Roche Pierre-Hugues , Bauchet Luc 
Published: October 2023

Abstract
Purpose
To describe the epidemiology of meningioma operated in France between 2006 and 2015.
Methods
We processed the French Brain Tumour Database (FBTDB) to conduct a nationwide population-based study of all histopathologically confirmed meningioma in France. Descriptive methods were implemented.
Results
30,223 meningiomas cases were operated on 28,424 patients, in 61 centres. Meningioma was 3 times more common in women (74.1% vs. 25.9%). Mean age at surgery was 58.5±13.9 years; 57.9±13.5 years for women vs.59.9 ±14.8 years for men (p<0.001). The incidence of meningioma surgery increased with age. Grade 1, 2, and 3 meningiomas accounted for 83.9%, 13.91% and, 2.19% respectively. The proportion of grade 2 significantly grew over the study period (p<0.001). There was a significant variability of meningioma grading by institutions, especially for grade 2 which spanned from 5.1% up to 22.4% (p <0.001). 89.05% of the patients had solely one meningioma surgery, 8.52% two and, 2.43% three or more. The number of surgeries was associated with the grade of malignancy (p <0.001).
Conclusion
The FBTBD is an effective source that comforts previous studies and, bring new information from 30,223 meningiomas cases operated on over a 10-year-long period.
Three quarters of meningioma were removed in women. The incidence of meningioma surgery increased with age and, peaked at 58.5 years. They were predominantly benign with meningothelial subtype being the most common. However, the rate of grade 2 has significantly grown over the time, on contrary to malignant meningioma proportion, which remained rare and stable over time around 2%.
Prognostic Value of HIF1A-AS3 in Breast cancer
Authors: Yong Liyun , Luis Manuel A , Yin XiaoXing , Cai Lu , Dique Marcia R , Tang Shasha , Cai Fengfeng 
Published: October 2023

Abstract
Breast cancer (BC) is the predominant malignant tumor among women globally. It has high recurrence which have adverse effects on patient outcomes. Therefore, there is need to identify effective biomarkers for prognostic evaluation. Numerous long non-coding RNAs (lncRNAs) have been shown to be implicated in the regulation of different stages of BC tumorigenesis. The role of lncRNA hypoxia-inducible factor 1 alpha-antisense RNA 3 (HIF1A-AS3) in BC has not been studied. The purpose of this study was to find a novel biomarker that can guide the formulation of effective treatments. The relationship between HIF1A-AS3 and BC was explored using the Breast Cancer on The Cancer Genome Atlas (TCGA-BRCA) database. The expression level of HIF1A-AS3 in various BC cells and normal breast cell, BC and paracancerous tissues from clinical patient samples, as well as primary breast cancer cell, respectively was analyzed. The R package was used to analyze RNA sequencing data and identify the differentially expressed genes (DEGs) between BC tissues with high and low expression of HIF1A-AS3 from the TCGA-BRCA database. Kaplan-Meier (KM) and Cox regression analyses were used in the current study to find the predictive value of HIF1A-AS3 on clinical outcomes in patients with BC. The association between infiltration of HIF1A-AS3 and immune cells was determined through Spearman's correlation analyses. The results revealed that the expression of HIF1A-AS3 was significantly elevated in breast cancer cell, BC tissues and primary breast cancer cell compared with that in normal breast cell, paracancerous tissues, and primary breast epithelial cell. KM analysis showed that high expression of HIF1A-AS3 was associated with poor OS [hazard ratio (HR): 1.42, P = 0.029], progression-free interval (PFS) (HR: 1.60, P = 0.005), and DSS (HR: 1.60, P = 0.031), especially in elderly patients below the age of 60, clinical T stage T1 and T2 as well as pathological stages III and IV. This suggested that higher HIF1A-AS3 expression levels were associated with unfavorable prognosis in BC. Moreover, analysis of immune infiltration showed that HIF1A-AS3 expression was associated with some types of immune infiltrating cells. The study identified that HIF1A-AS3 is a potential prognostic biomarker in BC.
Tertiary lymphoid structures critical for the prognosis of patients with cervical cancer
Authors: Zhang Qianqian , Wang Mengxin , Wu Suhui 
Published: October 2023

Abstract
Cervical cancer (CC) is the most common female reproductive system tumor. However, the tertiary lymphoid structures (TLSs) associated with CC have not been well studied. This study aimed to develop a novel TLS-based signature to stratify the prognosis of patients with CC and predict the clinical outcomes. The data were obtained from the TCGA (n = 292) and GEO (n = 300) databases. We classified TLS subtypes (C1 and C2) of CC based on the TLSs-9 gene signature using unsupervised hierarchical clustering, with the C1 subtype having a worse prognosis than the C2 subtype. Regarding immune-related features, immune and stromal scores, immune checkpoint gene expression, and tumor mutation burden were significantly higher in C2 than in C1. We found higher infiltration ratios of memory B cells, CD8+ T cells, activated memory CD4+ T cells, and activated macrophages in C2. Patients with C1 were more sensitive to cisplatin, doxorubicin, bleomycin, vinorelbine, and imatinib than those with C2. The risk score model and prognostic nomogram constructed based on the TLS signature were significantly and positively correlated with the survival rate of patients with CC. The presence of TLSs provides new insights into the prognosis of patients with CC, contributing to the precise stratification and accurate treatment.
Physicochemical Interaction of Microstructured Drumsticks withSynthetic Dye: The Tailoring of Surface Phenomenon in Technology
Authors: Rahman Md. Wasikur , Nipa Sumaya Tarannum , Shefa Nawrin Rahman , Akter Rumana , Khan Md. Maksudur Rahman , Uddin M. Jasim 
Published: October 2023

Abstract
The current study shows that drumstick powder (DSP) is a potential adsorbent to remove synthetic Congo Red (CR) from wastewater (WW) by a batch technique. CR as a textile waste harms the ecology and the water ecosystem, and it should be removed from WW. At various experimental conditions, various operating parameters such as initial concentration (IC) of dye (25–300 ppm), contact time (10–240 mins), pH (1–12) and adsorbent dosage (0.1-1.0 g/L) were investigated. The reaction kinetics and adsorption isotherms were examined. Maximum removal of dye has been found at pH 2. Dye concentration is an important factor, and it is inversely related to the percentage removal. 100 ppm was chosen as the IC for the optimization experiment. Increasing the amount of adsorbent dosage and contact time, there is a rise in the percentage removal of dye particles. The optimum adsorbent dosage was found 0.5 g/L and the contact time 90 mins. The maximum adsorption capacity (qmax) has been found to be 114.94 mg/g. The adsorption mechanism closely matched the Freundlich isotherm and pseudo-second order (PSO) kinetic models.
Modeling monthly streamflow of intermittent rivers in semi-arid regions using a hybrid forecasting model
Authors: Al-Juboori Anas 
Published: October 2023

Abstract
The process of forecasting the monthly flows of intermittent rivers is one of the important issues in hydrology as well as in managing water resources and designing hydraulic structures for those rivers. In this research, Support Vector Machine (SVM) model was used to predict the monthly flows of the Adhaim River in Iraq, and the results showed that the application of SVM model failed to model intermittent monthly flows, as the value of the determination coefficient did not exceed 0.23 in the validation stage of the model. A hybrid model consisting of three machine learning models, K-means clustering, Bayesian networks, and Support vector machine, was applied to predict intermittent monthly flows. The results proved the efficiency of the proposed hybrid model in predicting monthly streamflow. The value of the coefficient of determination was 0.84 at the model validation stage. The application of the proposed hybrid model improved the results by 72% compared to the implementation of the SVM model.
Frequency Stabilization of diode laser via Two-photon transitions spectroscopy induced by optical frequency comb pulses combined with diode laser
Authors: zhang yichi , han hongyan 
Published: October 2023

Abstract
We present the observation of high-precision direct frequency comb spectroscopy
excited by an optical frequency comb and a diode laser when each of them
drives one step of the two-photon transitions in a rubidium vapor system. We
demonstrate a stable and low noise system by directly locking the frequency of
continuous-wave laser to rubidium two-photon transitions. The frequency stabil
ity of diode laser via two-photon transitions locking technique is 8*10−11 for a
1-s gate time and 3*10−12 for 1000-s. It proves a potential technique to locking
the diode laser with high stability. We choice the suitable optical frequency comb
pulse and the frequency of diode laser to fulfill the double-resonance condition.
These techniques eliminate spectrum lines overlap would benefit spectroscopy
measurement.
Educational Interventions for Imposter phenomenon: a scoping review
Authors: Siddiqui Zaha Kamran , Church Helen , Jayasuriya Raveen , Boddice Timothy , Tomlinson James 
Published: October 2023

Abstract
Background
Imposter Phenomenon (IP) is a subjective feeling of intellectual fraud and self-doubt experienced by individuals in goal-orientated high-achieving professions, regardless of gender. The impact of IP within healthcare has been associated with individual physical and mental health and concerns around training, career progression and DEI at an institutional level. To effectively address IP in healthcare, this scoping review aims to explore educational interventions designed to empower high-achieving individuals with the tools needed to confront and overcome IP.
Methods
The scoping review adhered to a predetermined protocol informed by the JBI methodology and PRISMA-ScR guidelines in order to identify educational interventions addressing IP in high-achieving industries. Articles were searched across multiple databases, including MEDLINE (Ovid), PsychINFO, SCOPUS, and Web of Science, alongside grey literature, without imposing any time constraints.
Results
Seventeen articles were incorporated into the review, with the majority originating from the USA and majority being published since 2020. Ten studies targeted healthcare professionals, undergraduate and postgraduate healthcare students. Majority of studies aimed at addressing IP, featured a larger number of female participants than males. Workshops with self-reflection and group-guided exercises to overcome IP were the most popular educational interventions. Coaching and structured supervision were also suggested. Across all papers, three themes emerged for coping strategies: individual, peer-to-peer, and institutional.
Conclusions
This scoping review suggests how group and individual interventions such as workshops, small group discussions and coaching can be used to overcome IP in healthcare. Institutional changes like diversity promotion, supervisor education, and support networks are crucial in addressing IP. Further long term and speciality specific assessments are needed to measure impact. Overall, the review highlights how educational awareness and a variety of strategies can be implemented to create a supportive environment for professionals dealing with IP, promoting their well-being and success.
The long-term outcome and safety of severe aplastic anemia treated with porcine antilymphocyte globulin plus cyclosporine, with or without thrombopoietin receptor agonists: a double-center retrospective study
Authors: Liang xingquan , xu shan , xiao yue , Lu yan , deng mingyang 
Published: October 2023

Abstract

Objectives: To evaluate the long-term outcome and safety of porcine antilymphocyte globulin plus cyclosporine, with or without thrombopoietin receptor agonist (TPO-RA), for patients with severe aplastic anemia (SAA) and identification of factors influencing hematology response and long-term outcome.
Methods: We retrospectively analyzed the data of 85 people with newly diagnosed SAA who underwent porcine antithymocyte globulin (p-ATG) plus cyclosporine (CsA), with or without TPO-RA in the second Xiangya hospital and the first people’s hospital of Chenzhou during 2014 to 2023.
Results: The overall response rates were 55.3% and 65.9% with 3 and 6 months. Hematologic response rates for the TPO-RA group were 66.7% and 72.3%, at 3 and 6 months and without the TPO-RA group were 27.8% and 55.6%. In multivariate analysis, platelet count＞10x109/L was a predictor of favorable response at 6 months (P= 0.015). The median follow-up time for all patients was 39 months (range 0.4~104), the 5-year OS rate of 90.6% [95% CI = 82.1–95.2%], and the FFS rate was 68.9% [95% CI =56.6–78.4%]. The very severe aplastic anemia（VSAA）subgroup was an independent unfavorable predictor of failure-free survival (FFS) and overall survival (OS). 12 patients (14.1%) suffered from serum sickness, and 9.5% of patients had mild hepatic impairment.
Conclusions: p-ATG can be used as an appropriate alternative preparation for rabbit ATG, with fewer side effects and lower medical costs, and combined with TPO-RA may improve early hematologic response rates.
Experimental Study on Fatigue Mechanical Properties and Acoustic Emission Behavior of Hard Layer Sandstone under Cyclic Disturbance
Authors: Cheng Yun , Song Zhanping , Wu Fahong , Yuan Wei , Yang Tengtian 
Published: October 2023

Abstract
The fatigue deformation of sedimentary rock at tunnel bottom under the train disturbance load contains the mechanical damage behavior. The fatigue mechanics test and acoustic emission (AE) monitoring are carried out to investigate the fatigue deformation and AE response characteristics of layer sandstone under fatigue load. This study showed that there is a time-sensitive correspondence between hysteresis loop and layer degradation effect. The hysteresis loop undergoes intensive distribution, strain transition, sparse distribution and fracture instability, and the continuous stress drops induces a significant strain transition. The layer structure has a significant deterioration effect on bearing strength and fatigue life. The cycle peak strength is degraded by 15.05%-28.19% compared with static peak strength. The fatigue life is positively correlated with peak strength and fatigue life decreases first and then increases with the layer angle increasing. The fracture modes of layer sandstone has anisotropic properties, including tensile fracture I, tensile fracture Ⅱ, shear fracture and composite fracture, and the fractal dimension is negatively correlated with layer degradation effect. AE amplitudes at low-medium-high stress levels are distributed in banded shape, tower shape and semi-tower shape, showing a time-corresponding relationship with the stress paths. There is a competitive relationship between compaction strengthening and fracturing damage. The evolution stages of AE damage variable include damage calm phase, damage acceleration phase and damage burst phase, and 0.20 is the starting point of damage acceleration and mutation damage (DAE−C) near the peak stress indicates a complete fracture. The stronger the layer deterioration effect, the smaller the DAE−C. The result may be represents a useful complement to mechanical properties of sedimentary rocks and is of important for ensuring the rock engineering safety.
Preparation of Cu(І)Y from binary Cu(II) precursors and its CO adsorption performance
Authors: Zhang Jiali , Li Xue 
Published: October 2023

Abstract
Separation and purification of CO is an important chemical process. Adsorption is competitive due to its efficient operation, low energy and matured technology. For CO adsorption, the capacity and selectivity of the adsorbent is the key factor to determine the efficiency. In this paper, C2H5OH was used as the dispersing agent, CuCl2 and Cu(CH3COO)2 were used as the precursors mixing with HY molecular sieve, then followed by activation at different temperatures to prepare CO adsorbents. The maximum CO adsorption capacity was 42 mL/gHY, which was 28.4 % higher than that of the adsorbent prepared with water as the dispersing agent. The adsorbents were characterized by BET, XRD, XRF, XPS and TG-MS. It was revealed that Cu(II) can be reduced to Cu(I) at 290℃ and highly dispersed on surface of HY. Ion exchange occurred between HY molecular sieve and Cu((I) salts, and Cu (I) Y came into being. Compared with Cu(II), Cu and even CuCl/HY, Cu (I) Y had the best CO adsorption performance.
A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma
Authors: Li Congya , Ding Linchao , Wang Xuyao , Shu Peng , Shi Xuchao , Zheng Zhijian , Liu Jian , Zhu Junlan 
Published: October 2023

Abstract
Background
Circular RNAs (circRNAs) are a class of noncoding RNAs that are involved in the progression of many human cancers. The precise gene locus and the roles of circular RNA from Fibronectin type III domain containing 3B (FNDC3B) in OS and its mechanisms of action have not been fully explored.
Materials and methods
qRT-qPCR assay was used to determine gene expressions. CCK8 Assay, EdU assay, wound-healing assay, transwell invasion assay and in vivo xenograft assay were used to perform functional investigations. RNA-FISH, immunofluorescence, RIP assay, RNA stability analysis were applied in mechanistic studies.
Results
We found that circFNDC3B downregulated and FNDC3B mRNA upregulated in OS, and might be potential biomarkers for indicating disease progression and prognosis of OS patients. CircFNDC3B acted as a tumor suppressor gene to restrain OS progression and FNDC3B functioned as an oncogene to promote OS progression in vitro and in vivo. RNA binding protein RNA binding motif protein 47 (RBM47) could bind to the flanking introns of circFNDC3B to facilitate the generation of circFNDC3B, resulting in the reduction of FNDC3B mRNA and the circFNDC3B-FNDC3B mRNA imbalance. CircFNDC3B also inhibited FNDC3B mRNA expression by reducing its stability via competitively binding to Insulin-like growth-factor-2 mRNA binding protein (IGF2BP1).
Conclusion
This study demonstrated that RBM47 and IGF2BP1 mediated circular FNDC3B/FNDC3B mRNA imbalance was involved in the malignant processes of OS.