bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation and validation to the Arabic language of the Climate Change Anxiety Scale (CCAS)
Authors: Fekih-Romdhane Feten , Malaeb Diana , Yakın Ecem , Sakr Fouad , Dabbous Mariam , Khatib Sami El , Obeid Sahar , Hallit Souheil 
Published: January 2024

Abstract
Background
The Arab world is one of the global regions the most directly concerned by, and suffering from climate change’s adverse consequences. As such, there appears to be a strong need for an understanding of how Arab people may emotionally respond to climate change. Providing valid and reliable measures of climate change anxiety (CCA) can help gain a clear overview of the situation in Arab countries, and allow to intervene timely and effectively to mitigate any adverse effects on Arab people’s mental health. To this end, the present study sought to validate the Arabic language version of the Climate Change Anxiety Scale (CCAS) in a sample of native Arabic-speaking adults from the general population of Lebanon.
Methods
This study adopted a cross-sectional approach and enrolled 763 adults between July and September 2023.
Results
A confirmatory analysis of the one-factor model showed poor fit indices as follows: CFI = .90, GFI = .83, SRMR = .048 and RMSEA .131 [90% CI .123, .138). The two-factor model showed a satisfactory fit with a high CFI of and a GFI of 0.91 and a SRMR of 0.04 and RMSEA of 0.05 [90% CI 0.04, 0.06]. Both McDonald’s omega and Cronbach alpha values were high for the overall CCAS score (α = .96 and ω = .96) in the whole sample. Configural, metric and scalar invariance across gender was demonstrated. No significant difference was found between males and females in terms of total CCAS scores (24.53 ± 10.59 vs 26.03 ± 11.17, t(761) = -1.82, p = .069). Higher CCA, functional impairment and cognitive impairment scores were significantly associated with higher depression, anxiety and stress.
Conclusion
The reliability and validity of the CCAS in its Arabic version were proven. The availability of this self-report measure could offer a chance to assess CCA among Adults speaking Arabic, and to spread its future use for screening and research purposes.
Reliability of industrial-scale telescopes in the event of seismic failures
Authors: Cho Anthony D. , Jiménez Dora , Guevara Esnil 
Published: January 2024

Abstract
Natural disasters have the potential to pose a significant threat to property, critical infrastructure, human health and safety, and some others. One of the most relevant natural disasters is earthquakes, which are high on the list of natural phenomena that most affect infrastructures and, at the same time, are the most unpredictable. This study uses the probabilistic seismic risk analysis method to estimate the condition of an industrial-scale telescope after the effect of an earthquake. The approach considers a seismic source model and ground motion prediction equations to evaluate the intensity measure of each telescope as a function of its location. Our simulation uses reliability via Monte Carlo to discover the probability of failure of each telescope taking into consideration the fragility curves described by its nature structure. Our method incorporates terrain characteristics and component robustness into the analysis of telescope performance at an affordable computational cost. We applied our method to the observatories that use industrial-scale telescopes established in Chile, and we showed that reliability is highly dependent on the robustness/fragility of the infrastructure.
MSC Classification: 62P12 , 62P30 , 90B25
Exploring the Mechanism of Dendrobine in Treating Non-Alcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Validation
Authors: Li Feng , Wu Jialin , Zhu Ye , Zhang Xiaoyan , Wang Miao , Zhou Shigao 
Published: January 2024

Abstract
This research delves into the therapeutic mechanisms of Dendrobine, the primary bioactive compound in Dendrobium nobile, for Non-Alcoholic Fatty Liver Disease (NAFLD) management. Integrating network pharmacology with experimental validation, the study evaluates the clinical effectiveness and safety of Dendrobium nobile in NAFLD treatment through an exploratory clinical trial. The approach identifies Dendrobine's potential targets and associated genes, constructing an interactive gene network. Validation processes include functional genomics, pathway enrichment analysis, molecular docking, cellular assays, and qPCR. Results demonstrate Dendrobium nobile's efficacy in enhancing liver function among NAFLD patients. Network pharmacology findings indicate Dendrobine’s influence on key targets like PPARG, IL6, TNF, IL1B, and AKT1, with molecular docking confirming interactions across these targets, excluding NFKB1. Dendrobine significantly reduced ALT and AST levels in PA-treated HepG2 cells, suggesting hepatoprotective properties, and ameliorated oxidative stress by lowering MDA levels and increasing SOD levels. The findings suggest Dendrobine's role in modulating inflammatory and immune responses, potentially through the downregulation of inflammatory mediators like TNF, IL6, and IL1B, and influencing lipid metabolism via AKT1 and STAT3 inhibition, thereby mitigating liver damage in NAFLD.
Acute myeloid leukemia patients with high-risk karyotypes benefit from decitabine in combination with modified CAG
Authors: Liu Wen-Jie , Sun Qian , Zhu Yu , Zhao Xiao-Li , Li Jian-Yong , Qian Si-Xuan , Hong Ming 
Published: January 2024

Abstract
This study aims to investigate the cytogenetic and molecular characteristics of patients with Acute Myeloid Leukemia (AML) and determine which patients would benefit most from a low-intensity regimen of decitabine in combination with modified CAG (D-CAG) or intensive chemotherapy. We retrospectively analyzed cytogenetic and molecular data from 331 newly diagnosed AML patients and investigated the relationship between genetic characteristics, risk status, treatments and clinical outcomes. The median followed-up was 45 months (2-120 months). Overall, a single cycle of IA induction resulted in a CR rate of 79.3%, which was superior to the 66.4% observed in the cohort treated with D-CAG (P < .05). However, there was no significant difference in ORR between the two arms. The median OS was reduced in the D-CAG cohort compared to the IA cohort (P < .05). Favorable-risk groups and patients who undergo allo-HSCT treated with IA had longer OS than those in the D-CAG groups (P < .05). While the median OS of the intermediate- and high-risk groups who were not recipients of allo-HSCT was comparable between two regimen. Within the IA group, patients with TET2, NRAS, and biallelic CEBPA gene mutations achieved better OS than those in the D-CAG group (P < .05). While older patients with complex and monosomal karyotypes were tend to have longer median OS compared to younger patients (P < .05). In conclusion, it is crucial to select AML chemotherapy regimens based on karyotypes and genetic characteristics. D-CAG may be a better choice for AML patients with high-risk karyotypes.
Healthcare Providers' Perspectives on Sustaining Respectful Maternity Care Appreciated by Mothers, in Five Hospitals of Rwanda
Authors: Muhayimana Alice , Kearns Irene 
Published: January 2024

Abstract
Background: Childbirth demands respect, as emphasized by the World Health Organization in 2018 and the focus towards the need for positive, dignified delivery experiences, has become an integral aspect of Respectful Maternity Care (RMC). It is a known fact that RMC is pivotal for favorable birth outcomes and reduce mistreatment during childbirth. Absence of RMC violates women and newborns' rights, and the study aims to explore Health Care Providers' perspectives on sustaining RMC actions previously reported by mothers.
Methodology: This study was conducted in five hospitals in the Eastern province of Rwanda, involving 5 Focus Group Discussions (FGDs) with midwives and nurses. For interviews, we purposively selected 5-unit managers and 5 physicians. Additionally, 40 midwives and nurses were recruited for the FGDs. The research utilized the Dream phase of Appreciative Inquiry (AI) for interviews and Focus Groups. Data collection aimed to gain insights into Healthcare Providers' perceptions of how RMC is provided and how to establish and to sustain RMC in Rwandan health facilities. Nvivo 12 was employed for organizing codes and creating a codebook, and thematic analysis was applied.
Results: 4 themes emerged and their sub-themes.1) Women centered care withCompassionate care, Privacy and confidentiality maintenance, Information provision and liberty in decision making, Effective communication, Family involvement, Cleanness Equality care. 2)Professionalism compliance with Motivated staff, Teamwork, Continuous development, Quality work provision, Community trust. 3) RMC encounters 4) RMC sustenance
Conclusion and recommendations: The continuous pursuit of high RMC standards in Rwanda involves improving childbirth experiences through utilizing existing resources, ongoing improvement, and sustaining achievements. Key recommended actions in this study for sustaining RMC encompass promoting women-centered care, enhancing healthcare provider attitudes, ensuring professionalism, building community trust, maintaining conducive health facility environments, and involving leadership
Modeling Lassa fever in Nigeria with perception of risk
Authors: Agusto Folashade B. 
Published: January 2024

Abstract
Lassa fever is an acute viral hemorrhagic disease caused by Lassa virus. It is transmitted to humans through direct contactwith infected mastomys natalensis rodents, or through food or household items contaminated with urine or feces of infectedrodents. Nigeria is an endemic country for Lassa fever, the current overall risk at the national level is considered high due toseveral factors including lack of awareness and education about the disease. In this study, a mathematical model of Lassa fevertransmission with perception of risks was developed. The model was parameterized using Lassa fever data from 2017-2022obtained from Nigerian Centers for Disease Prevention and Control. Results of the global sensitivity analysis shows thesignificant impact of rodent-to-rodent, rodent-to-human and human-to-human transmission probabilities, as well as perceptionof risks terms on the response functions. Other influential parameters are the rodent growth and death rates as well as humanrecovery and disease progression rates. Humans’ natural death and disease induced death rates including perception of riskdecay term all have impact on the response functions. The distribution profile of the reproduction number values is within theinterval [0.7801,3.0049] for years 2017–2022. The simulation results show that increase in transmission probabilities increasethe disease burden in the community while increase in perception of risks of the disease decreases the disease burden.
Exploring the Reasons for Defaulting from Childhood Immunization: A Qualitative Study in District Swat Pakistan
Authors: Ullah Kifayat , Saleem Javeria , Zakar Rubeena , Ishaq Muhammad , Khattak Farhad Ali , Majeed Fatima , Sadiqa Hafiza Aisha , Fischer Florian 
Published: January 2024

Abstract
Background:Childhood vaccination is widely recognized as the most effective means to prevent various diseases. However, a considerable amount of children still miss out on their vaccination schedules. Therefore, this study explores the reasons for defaulting from the expanded program on immunization in district Swat, Pakistan.
Methods: A qualitative phenomenological approach was used. Data collection took place from March to September 2022. Thirty-six in-depth interviews were conducted with participants who had defaulter children. The collected qualitative data were analysed thematically to identify key patterns and themes related to the reasons for defaulting from childhood vaccination schedules.
Results: Six themes emerged, i.e., illness of the defaulter child at the scheduled time, perceived side effects of the vaccination, factors related to caregivers, myths and misconceptions, vaccinators attitudes and crowed vaccination centres, as well as poor immunization service arrangements. Four subthemes arose related to caregivers, such as lack of clear understanding about completion of vaccination, least priority for child’s vaccination, cultural restriction on mothers, and the loss of vaccination card.
Conclusion:According to the study’s findings, most caregivers had their perceptions about not completing the children’s vaccination schedule. The vaccination completion rate may be increased if the concerns of the caregivers are appropriately addressed.
Assessing and comparing Knowledge, Attitude, and Practices related to Water, Sanitation and Hygiene Among Government and Non-government School students in Gujarat: A Mixed-Method Study
Authors: Patel Monika , Gupta Eshwar Kumar , M Yogesh 
Published: January 2024

Abstract
Background: Water, sanitation, and hygiene (WASH) practices are vital for health, especially among school students who can propagate messages. Comparing WASH knowledge, attitudes and practices between government and non-government schools can guide tailored interventions. This mixed methods study aimed to assess and compare WASH-related knowledge, attitudes, and practices among adolescents in government versus non-government schools in Gujarat, India.
Materials and Methods: A cross-sectional survey was conducted among 566 students from 17 government and 17 non-government schools. Interviews using a standardized questionnaire provided quantitative data on WASH-related knowledge, attitudes, and practices. Qualitative data was gathered through focus group discussions exploring influences on student WASH behaviors. Analyses included descriptive statistics, group comparisons, multivariate regression, and thematic analysis. A-value of P <0.05 was considered significant.
Results: In total, 566 students participated, with 257 (45%) from government and 309 (55%) from non-government schools. Non-government students showed significantly better knowledge of handwashing (AOR 1.9, 95% CI 1.3-2.7), fecal-oral transmission (AOR 1.8, 95% CI 1.3-2.5), open defecation (AOR 1.7, 95% CI 1.2-2.4), and menstrual hygiene (AOR 3.2, 95% CI 1.1-9.2). More non-government students had positive attitudes about safe drinking water (AOR 4.1, 95% CI 1.8-9.6), conserving water (AOR 2.0, 95% CI 1.4-2.9), cleanliness (AOR 1.8, 95% CI 1.1-2.9), investing in hygiene (AOR 5.3, 95% CI 3.1-9.2), and menstrual management (AOR 2.1, 95% CI 1.2-3.6). In practices, non-government students showed higher use of soap (AOR 1.9, 95% CI 1.3-2.8), better menstrual hygiene (AOR 5.9, 95% CI 3.2-10.9), and more sanitary defecation (AOR 2.7, 95% CI 1.8-4.0). Superior WASH outcomes were associated with older age (AOR 1.8, 95% CI 1.1-3.0), urban locality (AOR 2.3, 95% CI 1.5-3.5), higher parental education (AOR 2.1, 95% CI 1.3-3.4), and affluence (AOR 3.1, 95% CI 1.8-5.2). Qualitative data highlighted knowledge gaps, inadequate facilities, detrimental cultural beliefs, poverty, and the need for government support.
Conclusions: Disparities exist in WASH behaviors between school types, suggesting the need for tailored interventions addressing specific gaps. Schools play a critical role in cultivating proper hygiene through infrastructure provision and targeted education. Government schools may require extra support to overcome challenges related to WASH access and quality.
Unraveling the Ground Subsidence Disaster Caused by Rock Salt Mining in Maceió (Northeast Brazil) from 2020 until Rupture Using Sentinel-1 Data
Authors: Mantovani Jose , Enner  
Published: January 2024

Abstract
Maceió, the capital of Alagoas, grapples with subsidence, a geophysical challenge rooted in coastal influences, anthropogenic activities, and geological factors. The consequences, ranging from structural damage to increased flood vulnerability, impact communities, notably in neighborhoods like Bebedouro and Farol. Addressing subsidence demands a comprehensive approach, integrating geotechnical engineering, urban planning, and environmental management. The dataset reveals a nuanced relationship between subsidence and urban parameters. High-density urban areas bear a disproportionate burden, emphasizing the intricate link between urbanization and ground movement. The influence of topography challenges assumptions, indicating that areas with steeper slopes exhibit lower rates of ground movement. Temporal analysis underscores the dynamic nature of subsidence, influencing the spatial distribution of occupied areas. Recognizing subsidence as an evolving phenomenon allows for adaptive strategies in dynamic urban planning. This aligns with existing literature, emphasizing the need for adaptive planning, resilient infrastructure, and targeted interventions. In conclusion, Maceió's subsidence challenges necessitate a geotechnically informed, nuanced approach, considering local variations, community engagement, and temporal dynamics. Collaborative efforts between stakeholders are crucial for sustainable solutions and urban resilience in the face of subsidence-induced complexities.
FATP2 activates PI3K/Akt/mTOR pathway by inhibiting ATF3 and promotes the occurrence and development of bladder cancer
Authors: Jiang Ming , Chen Ru , Hu Bing , Xiong Situ , Li Sheng , FU Bin , Liu Xiaoqiang 
Published: January 2024

Abstract

Bladder cancer (BLCA) is ranked among the main causes of mortality in male cancer patients, and research into targeted therapies guided by its genomics and molecular biology has been a prominent focus in BLCA studies. Fatty acid transporter protein 2 (FATP2/SLC27A2), a member of the FATPs/SLC27As family,is a key contributor to the progression of cancers such as hepatocellular carcinomas and melanomas.However,its role in BLCA remains poorly understand. This study delved into the function of FATP2 in BLCA through a succession of experiments in vivo and in vitro, employing techniques as quantitative real-time polymerase chain reaction (qRT-PCR), RNA sequencing, transwell assays, immunofluorescence,western blot,and others to dissect its mechanistic actions. The findings revealed that an oncogenic function is executed by FATP2 in bladder cancer, significantly impacting the proliferation and migration capabilities, thereby affecting the prognosis of BLCA patients. Furthermore, A suppression that relies on both time and concentration of BLCA proliferation and migration, trigger of apoptosis, and blockage of the cell cycle at the G2/M phase were observed when the inhibitor of FATP2, Lipofermata, was applied. It was unveiled through subsequent investigations that ATF3 expression is indirectly promoted by Lipofermata through the inhibition of FATP2, ultimately inhibiting the signal transduction of the PI3K/Akt/mTOR pathway. This effect was also responsible for the inhibitory impact on BLCA proliferation. Therefore, FATP2 emerges as an auspicious and emerging molecular target with potential applications in precision therapy in BLCA.
Serum Neurofilament Light Chain and Inflammatory Cytokines as Biomarkers for Early Detection of Alzheimer's Disease
Authors: Jing Xinyang , Wang Lan , Song Mei , Geng Hao , Li Wei , Huo Yaxin , Huang Anqi , Wang Xueyi , An Cuixia 
Published: January 2024

Abstract
Objective: To investigate the association between serum neurofilament light chain (NfL) levels, inflammatory cytokines, and cognitive function to assess their utility in the early detection of Alzheimer's disease (AD).
Methods: We conducted a cross-sectional study involving 157 community-dwelling individuals aged 55 years and above, categorized into healthy controls, mild cognitive impairment (MCI), and probable AD. Serum levels of NfL, inflammatory cytokines, and AD pathology markers were measured using enzyme-linked immunosorbent assay (ELISA). Correlations between these biomarkers and cognitive function were analyzed, for the potential of serum NfL in recognizing MCI.
Results: Serum NfL levels were significantly elevated in MCI and probable AD groups compared to healthy controls. Positive correlations were found between serum NfL and inflammatory cytokines IL-1β, IL-6, and Aβ40. Combining serum NfL with p-tau217 and the Boston Naming Test significantly enhanced the predictive accuracy for MCI. However, combining serum NfL with inflammatory markers did not improve MCI prediction accuracy.
Conclusions: Elevated serum NfL is associated with cognitive impairment and inflammatory markers, suggesting its potential as a peripheral blood biomarker for early AD detection. The combination of serum NfL with p-tau217 and cognitive tests could offer a more accurate prediction of MCI, providing new insights for AD treatment strategies.
Xanthine oxidase modulates Glutamic Acid Decarboxylase 65 isoform (GAD65) protein expression in rat pancreatic islets
Authors: RAZDAN KONIKA , RAINA VARSHIESH 
Published: January 2024

Abstract

Background: It is widely presumed that aberrant expression of GAD65 can sensitize beta cells to autoimmunity and moreover, several studies indicate Xanthine Oxidase (XO) plays significant role in Type-1 diabetes (T1D) pathology. The present study aimed to investigate whether XO modulates GAD65 protein expression in rat islets/pancreas in presence or absence of STZ.
Methods and results: Female Wistar rats were used for pancreatic islet isolation and T1D STZ model by injecting single dose of STZ (40 mg/kg body weight). GAD65 and XO protein expression was studied by immunoblot in islets/pancreas and STZ/T1D cytokines (such as IL-1 beta, TNF-α and IFN-γ)/XO siRNA/Allopurinol (XO inhibitor)/1400W (iNOS inhibitor) were used in treatment groups. Enzymatic assay was done to measure XO activity in islets/serum/pancreas and iNOS activity in culture supernatant. STZ led to a significant increase in GAD65 expression and XO activity in islets which was reduced in presence of Allopurinol and XO siRNA. In pancreas of T1D rat model, expression of GAD65 decreased and XO increased; XO activity decreased; whereas in sera XO activity increased. Treatment of islets with T1D cytokines revealed that cytokine cocktail declined GAD65 protein levels and XO activity and intervention with iNOS inhibitor reversed the effect. During ontogeny of pancreas GAD65 expression was more in the fetal/infantile pancreas compared to adult pancreas and Allopurinol challenged pregnant rats confirmed that GAD65 expression is dependent on XO activity. Conclusion: This study for the first time clearly demonstrates that XO is positive regulator of GAD65 expression in rat islets and STZ-T1D model.