bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of Preoperative Staging for Clinically Localized Merkel Cell Carcinoma
Authors: Garcia Natalie , Jiminez Victoria , Duncan Zoey , Correya Tanya , Amu-Nnadi Chimaraije , Broman Kristy 
Published: November 2023

Introduction: For Merkel Cell Carcinoma (MCC), a rare cutaneous neuroendocrine cancer, treatment varies based on disease stage at presentation. For patients with localized disease, primary treatment is surgical resection. There is wide practice variation in the performance of preoperative imaging studies, which may upstage patients and/or change plans for surgical resection. The purpose of this study was to evaluate how preoperative staging with cross-sectional imaging influenced management of patients with clinically localized Merkel Cell Carcinoma.
Methods: We identified patients who were evaluated at our facility between January 1, 2012 and December 31, 2020 for clinically localized MCC (confined to the skin, without evidence of nodal spread or signs/symptoms of distant disease) prior to surgical resection. The primary outcome was the proportion of patients whose management changed based on preoperative imaging.
Results: There were 97 patients, of whom 84 (87%) had preoperative staging studies. Patients had a median age of 75 years, 13% were immunosuppressed, and 81% had tumors <2cm. There were no differences in the clinical characteristics of patient based on whether staging was performed. PET/CT was performed in 52(67%) patients, 51(62%) CT, 31(41%) brain MRI. There were 5 patients with indeterminate findings (all on PET/CT), but there were no patients for whom preoperative staging changed the plan for surgical resection.
Conclusion: There were no changes in surgical management based on results of preoperative imaging. More selective use of preoperative imaging staging may be warranted, potentially considering risk factors for clinically occult micro-metastatic disease.
Patient- and Clinician-Reported Outcomes of Tirbanibulin 1% in the Treatment of Actinic Keratosis on the Face and Scalp (PROAK Study)
Authors: Schlesinger Todd , Armstrong April , Patel Vishal A. , Kircik Leon , Berman Brian , Bhatia Neal , Lebwohl Mark , Rigel Darrell , Narayanan Siva , Koscielny Volker , Kasujee Ismail , Del Rosso James 
Published: November 2023

Introduction: Actinic Keratosis (AK) has been shown to negatively affect emotional and social functioning and skin-related quality of life [1]. The objective was to evaluate clinician- and patient-reported outcomes (ClinRO; PRO) for tirbanibulin treatment satisfaction and effectiveness among patients administered tirbanibulin in routine clinical practice across the U.S.
Methods: A single-arm, prospective cohort study (PROAK: NCT05260073) was conducted in adults with AKs on the face or scalp as part of usual care. Patients and clinicians completed surveys and clinical assessments at baseline, Week-8, and Week-24. ClinRO and PRO comprised Treatment Satisfaction Questionnaire for Medication (TSQM-9) (with 3 domains: treatment effectiveness, convenience of use, and global satisfaction with treatment) and Expert Panel Questionnaire (EPQ) (assessing overall skin appearance, satisfaction with improvement in “skin texture” and “how skin looks”, and likelihood to consider tirbanibulin again). Clinicians assessed AK responses using Investigator's Global Assessment (IGA) and patient’s skin photodamage severity scale. IGA success was defined as achieving IGA score of 0-1 (≥75% AK lesions clearance). Data at Week-8 was already published [1]. Here we present the results obtained at Week-24.
Results: A total of 278 patients completed study assessments at Week-24 (mean age: 66.3 years; 68.6% males; Fitzpatrick skin type II: 71.4%). Mean (standard deviations [SD]) TSQM-9 score in effectiveness, convenience and global satisfaction was 74.3 (21.2), 84.5 (15.6) and 74.9 (23.9) for clinicians and 73.4 (21.4), 85.0 (14.7) and 71.9 (24.7) for patients. 77.3% of clinicians and 78.4% of patients reported a high likelihood for considering tirbanibulin treatment in the future. At Week-24, 83.6% of clinicians and 78.5% of patients rated overall skin appearance after tirbanibulin treatment to be mostly somewhat/much improved. At Week-24, the proportion of patients with completely/partially cleared AK (IGA 0/1) was 71.9%, similar to that obtained at Week-8 (73.8%) [1].
Conclusions: Effectiveness ≥75% clearance was achieved by 71.9% of patients, consistent with the results of the Phase III trials [2]. ClinRO and PRO demonstrated high satisfaction with once-daily tirbanibulin treatment for 5 consecutive days at Week-24, and both clinicians and patients reported a desire to consider tirbanibulin treatment in the future.
[1] Schlesinger T et al. Skin. 2023;7(3):771-787.
[2] Blauvelt A et al. N Engl J Med. 2021;384(6):512–20.
Outcomes of Down-Titration in Patients With Severe Scalp Alopecia Areata Treated With Baricitinib: An Update Through Week 152 From BRAVE-AA2
Authors: King Brett , Ohyama Manabu , Senna Maryanne , Shapiro Jerry , Dutronc Yves , Kolodsick Jill , Yu Guanglei , Liu Chunyuan , Chiasserini Chiara , Piraccini Bianca Maria 
Published: November 2023

Introduction: Baricitinib is approved for the treatment of patients with severe alopecia areata (AA). The efficacy results from the down-titration portion of the phase 3 trial BRAVE-AA2 have been reported up to Week-104. Here we report both long-term efficacy outcomes from the down-titration portion of BRAVE-AA2, and recapture data after retreatment.
Methods: BRAVE-AA2 enrolled 546 adults with severe AA (Severity of Alopecia Tool [SALT] score ≥50). At Week-52, patients initially randomized to 4mg baricitinib who had scalp hair response (Responders: SALT score ≤20) were eligible to be rerandomized 1:1 to remain on 4mg or down-titrate to 2mg. Retreatment with baricitinib 4mg for those patients who were down-titrated was triggered by a loss of treatment benefit defined as a 20 points or greater worsening in SALT score from Week-52. Last observation carried forward was used to impute missing or censored data.
Results: Among 86 responders at Week-52, 42 were down-titrated from 4mg to 2mg baricitinib. At Week-104 and 152 respectively, 66% and 59% of down-titrated patients had maintained a SALT score ≤20, compared to 91% and 89% of responders who remained on baricitinib 4mg. Among down-titrated patients, at Weeks 104 and 152, 29% and 37% experienced a loss of treatment benefit, respectively. For patients that remained on 4mg baricitinib, these proportions were 5% and 7%. Among patients who had achieved a SALT score ≤20 by Week-36 and had maintained it up to Week-52 before down-titration (sustained response), loss of treatment benefit by Week-152 occurred in 33% (11/33), compared to 50% (4/8) among patients who had not achieved sustained response. Among patients experiencing loss of benefit and retreated with baricitinib 4mg, the proportion of patients recapturing SALT score ≤20 increased over time, reaching 67% (10/15) for patients with ≥48 weeks of retreatment.
Conclusions: These data show that more than half of patients down-titrated to 2mg maintained clinical response up to 2 years after the down-titration. While more work is needed to define timing and conditions for a successful down-titration, data suggests that dosing of baricitinib can be modulated between 2mg and 4mg to adapt to the clinical response.
Funded by Eli Lilly and Company.
Mathematical model of controlled vane hydraulic shock absorber
Authors: Kozeletov S. V. , Saveliev S. V. 
Published: November 2023

Introduction. Modern technologies, as well as various methods and schemes currently used in technology, have made it possible to automatically control the damping properties of shock absorbers, which increases the energy intensity of the entire suspension system. However, in order to use these solutions in practice, it is necessary to develop mathematical models of these damping elements. Such models serve as a theoretical tool for studying the described processes in order to implement the correct control action. As for such units as controlled (adjustable) vane shock absorbers, the studies carried out earlier on them are clearly not enough to ensure their effective operation in various conditions.The object of this study is a controlled vane hydraulic shock absorber.The purpose of this work is to carry out theoretical studies and improve the methodology for calculating controlled (adjustable) bladed hydraulic shock absorbers, in which magnetorheological fluid is used as the working fluid of the shock absorber.Research methods. The design and principle of operation of controlled vane hydraulic shock absorber with magnetorheological (MR) throttles are considered. Method of calculation is proposed and theoretical studies are performed on influence of change of volume flow rate of working medium of shock absorber in MR throttle on forces of resistance to rotation on shaft of shock absorber blade.The results of theoretical research. 1) Results of theoretical studies of change of volume flow rate of working medium of controlled hydraulic blade shock absorber are presented. 2) An adequate mathematical model is obtained that is suitable for calculating the characteristics of controlled (adjustable) hydraulic vane shock absorbers, where magnetorheological fluid is used as the working medium of the shock absorber, as well as for selecting control action in the control system. Conclusion. The results of the study are intended for organizations and enterprises engaged in the development and production of heavy high-speed tracked vehicles.The results of the studies can be used to refine the methodology for estimating the smoothness of the heavy high-speed tracked vehicles.
Required power calculation to small rotor tip drive
Authors: Nikolayev V. A. 
Published: November 2023

Introduction. The problem of accelerating and reducing the cost of road construction without reducing their quality can be solved by creating a complex of continuous units. The units, following each other, carry out the whole range of works aimed at the construction of roads. One of the elements of the continuous unit that forms the cuvette is a direct-flow rotary ripper. It was revealed that for excavation near the axis of rotation of the rotor of a direct-flow rotary ripper, a small rotor with a higher angular velocity coaxially with a large rotor should be installed. The small rotor contains of a small rotor tip with spiral knives, two teeth and two knives. Previously, the structural layout of the small rotor was determined, the height of the spiral of the spiral knife was calculated. By analyzing the interaction of the elements of the working bodies of the direct-flow rotary ripper with the soil, it is necessary to identify the power on the drive of the tip of the small rotor.The method of research. The calculation methods of power for the introduction of a cone into the ground, power for friction of the cone on the ground, power for the introduction of the end of the spiral knife into the ground, power for the introduction of a spiral knife into the ground in the radial direction, power to overcome the friction of the spiral knife on the ground, power to overcome the force of resistance of the soil to the rotation of the spiral knife have been developed.Results. On the basis of the developed methods, the parameters were calculated. From the spatial models of the forces of interaction with the soil of the spiral knife, their resultant, normal forces, the forces of resistance of the soil to the rotation of the spiral knife are revealed, the friction forces of the soil on the rear surfaces of the first and second turns of the spiral knife are calculated. The total power for the drive of the tip of the small rotor and the volumetric energy for the introduction of a cone with a spiral knife into the ground are calculated.Conclusion. The total power for the drive of the tip of the small rotor includes power for the introduction of the cone into the ground, power for friction of the cone on the ground, power for the introduction of the end of the spiral knife into the ground; power for the introduction of a spiral knife into the ground in the radial direction, power to overcome the friction of the spiral knife on the ground, power to overcome the force of resistance of the soil to the rotation of the spiral knife. The required power to drive the tip of the small rotor is 1127 W. The volumetric energy for the introduction of a cone with a spiral knife into the ground is 16.9 kJ / cubic meter.
Penyuluhan Hipertensi Pada Masyarakat di Dusun Dawe Desa Watuagung, Kecamatan Baturetno, Kabupaten Wonogiri
Authors: Saptadi Julian Dwi , Arianto Machfudz Eko , Dhaifullah Muhammad Fakhruddin , Zulhayudin Muhammad Fadillah 
Published: November 2023

Latar belakang: Kasus kesehatan pada masyarakat atau suatu kelompok di daerah pedesaan maupun kota tidak luput dari yang namanya penyakit, kasus kesehatan pada masyarakat memiliki berbagai macam permasalahan kesehatan yang tentunya tidak sama, maka hal tersebut tentunya harus segera diatasi dan menentukan prioritas permasalahan kesehatan yang tertinggi di daerah tersebut. Hipertensi merupakan masalah kesehatan prioritas yang ditemukan di lokasi pengabdian. Tujuan: Mengetahui suatu masalah kesehatan tertinggi di suatu daerah dan memberikan solusi terbaik guna untuk perbaikan yang bermanfaat dan juga penyuluhan dan sosialisasi kepada masyarakat agar lebih paham dalam pencegahan dan pengendalian penyakit hipertensi. Metode: metode yang digunakan dalam pengabdian adalah kuantitatif dengan desain studi yang digunakan adalah studi deskriptif, yang dilakukan dengan hasil wawancara dan observasi. Hasil: dari hasil pengabdian ditemukan bahwasannya kasus tertinggi di dawe RT 004 RW 004 yaitu Hipertensi maka dengan ditemukan hal tersebut dilakukan intervensi dengan cara penyuluhan mengenai hipertensi. Kesimpulan: memberikan solusi terbaik untuk pencegahan kenaikan dan terkena hipertensi dengan adanya penyuluhan dan juga untuk masyarakat di dusun dawe RT 004 agar senantiasa melakukan check tekanan darah seminggu sekali di pelayanan kesehatan.
Kata kunci: hipertensi, penyakit tidak menular, penyuluhan
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Abstract
Background: Health cases in the community or a group in rural or urban areas do not escape the name of disease, health cases in the community have various kinds of health problems which are certainly not the same, then this must be addressed immediately and find the highest priority health problems in the area. Hypertension is a priority health problem found in community service locations. Objective: To find out the highest health problem in an area and to provide the best solution for useful improvements as well as counseling and outreach to the public so that they have a better understanding of the prevention and control of hypertension. used in the research is quantitative with the study design used as a descriptive study, which was conducted with the results of interviews and observations. Method: The method used in this research is quantitative with the study design used as a descriptive study, which was conducted with the results of interviews and observations. Result: From the results of the study, it was found that the highest case was in Dawe RT 004 RW 004, namely Hypertension. Conclusion: provide the best solution for preventing the increase and getting hypertension by providing counseling and also for the community in Dawe hamlet RT 004 to always check blood pressure once a week in health services.
Keywords: hypertension, non-communicable disease, counseling
Penyuluhan dan Pembagian Kit Pengendalian Tikus dan Lalat Kepada Lansia
Authors: Wijayanti Anisa Catur , Ramadhan Irfan , Anggraeni Devi Ayu , Berlian Rahma Novita , Kandina Anggin Ati , Hidayah Avivah Ainun , Adiratna Kun , Dzikri Ridwan Saiful , Farida Intan Nur , Wijaya Cahyanita Sekar , Puspita Widya Galih 
Published: November 2023

Latar belakang: Lingkungan merupakan masalah kesehatan terbesar di Indonesia karena sanitasi dasar yang buruk, lingkungan fisik yang buruk, dan rendahnya perilaku hidup bersih dan sehat pada masyarakat. Penyakit yang berhubungan langsung dengan sanitasi yang buruk dan disebabkan oleh hewan pengerat seperti tikus dan lalat. Upaya yang dilakukan untuk mengendalikan populasi tikus dan lalat dengan cara pemasangan lem kertas lalat dan obat tikus yang dibagikan kepada masyarakat dalam bentuk KIT. Tujuan: Pengabdian ini bertujuan untuk mengetahui pengetahuan lansia tentang pengendalian tikus dan lalat serta cara penggunaan alat untuk mengendalikan tikus dan lalat. Pengabdian ini juga bertujuan untuk mengajak lansia bersama-sama melakukan upaya pengendalian tikus dan lalat serta menerapkan metode pembuangan bangkai tikus dan lalat yang efektif dan higienis. Metode: Metode kegiatan pengabdian ini adalah “One Groups Pretest-Posttest Design”. Hasil: Nilai rata – rata pre-test sebelum diberikan edukasi sebesar 46,76 dan setelah edukasi nilai rata - rata pos-test meningkat 76,09 (p= 0,000). Kesimpulan: Hasil pengecekan ulang serta monitoring dengan metode wawancara didapatkan hasil bahwa beberapa responden sudah melakukan pemasangan racun tikus terbukti efektif untuk membasmi tikus yang ada dirumah.
Kata kunci: lalat, lansia, penyuluhan, tikus
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Abstract
Background: The environment is the biggest health problem in Indonesia because of poor basic sanitation, bad physical environment, and low hygiene and healthy behavior in the community. Diseases directly related to poor sanitation and caused by rodents such as rats and flies. Efforts were made to control the population of rats and flies by installing fly paper glue and rat medicine which were distributed to the public in the form of KITs. Objective: This service aims to find out the knowledge of the elderly about controlling rats and flies and how to use tools to control rats and flies. This service also aims to invite the elderly to jointly carry out efforts to control rats and flies and apply an effective and hygienic method of disposing of dead rats and flies. Method: The method of this community service activity is "One Groups Pretest-Posttest Design". Result: The pretest average score before being given education was 46.76 and after education the posttest average score increased to 76.09 (p= 0.000). Conclusion: The results of re-checking and monitoring with the interview method showed that several respondents had installed rat poison which proved to be effective in eradicating rats in the house.
Keywords: flies, elderly, counselling, rats
El retorno del desierto y los espectros del Antropoceno en <em>Blanco Nocturno</em> de Ricardo Piglia
Authors: Andúgar Rafael 
Published: November 2023

Resumen:En la novela Blanco nocturno de Ricardo Piglia, el detective Croce intenta resolver un asesinato que plantea cuestiones sobre motivos raciales y económicos, simbolizando la alineación de los agentes económicos extractivos arraigados en el colonialismo. El paisaje de la pampa argentina se convierte en un lugar donde se cruzan el genocidio de las poblaciones indígenas y el desastre climático. A través del estudio de la connotación nostálgica del uso del desierto como paisaje, la novela conecta la perspectiva histórica de las narraciones del siglo XIX sobre la “Conquista del desierto”, donde los escritores retrataban los paisajes argentinos como un “desierto” vacío con el objetivo de colonizar la tierra y repoblarla, con las preocupaciones actuales sobre la desertificación.
Este artículo examina una serie de imágenes metafóricas, denominadas “espectros del Antropoceno”, que incluyen una fábrica abandonada en medio del “desierto”, la construcción de un centro comercial o la yuxtaposición de una amplia variedad del espectro electromagnético, como la luz eléctrica, para resaltar las ansiedades en torno al progreso tecnológico y la destrucción ambiental.
Palabras clave: Ecocrítica, Desertificación, Paisaje, Ecología, Ricardo Piglia, Espectros
Abstract:
In Ricardo Piglia’s novel Blanco nocturno, Detective Croce tries to solve a murder that raises questions of racial and economic motives, symbolizing the alignment of the extractive economic agents rooted in colonialism. The landscape of the Argentinean pampas embodies the intersection of indigenous genocide and climate disaster. Through the study of the nostalgic connotation of the use of the desert as a landscape, the novel connects the historical perspective of the XIX century narrations of the “Conquista del desierto”—, as writers depicted Argentinian landscapes as an empty “desert” with the objective of colonizing the land and repopulating it, with present-day concerns of desertification.
This article will examine a series of metaphorical images, referred to as the “specters of the Anthropocene,” which include an abandoned factory in the middle of the “desert,” the construction of a mall, and a juxtaposition of a diverse array of the electromagnetic spectrum such as electric light, to highlight anxieties surrounding technological progress and environmental destruction.
Keywords: Ecocriticism, Desertification, Landscape, Ecology, Ricardo Piglia, Specters
PEMBERDAYAAN BERBASIS MASYARAKAT DALAM PEMBUATAN BATA BETON BERBAHAN DASAR METAKAOLIN DAN ABU TERBANG DI DESA LIWUTUNG DUA, KAB. MINAHASA TENGGARA
Authors: Supit Steve , Priyono Priyono , Tulung Joy 
Published: November 2023

Program kegiatan pemberdayaan berbasis masyarakat ini melibatkan mitra kelompok usaha bata beton SUWALA di Desa Liwutung Dua Kec. Pasan Kab. Minahasa Tenggara dengan masalah utama adalah kurangnya kualitas produk bata beton. Untuk mengatasi permasalahan tersebut maka dilakukan kegiatan pemberdayaan dan penerapan teknologi campuran bata beton menggunakan sumber daya alam lokal dan limbah industri yakni metakaolin dan abu terbang. Tujuannya adalah untuk mengaplikasilan hasil penelitian kepada masyarakat melalui pembuatan bata beton berbahan dasar material lokal guna meningkatkan daya saing dan kesejahteraan kelompok usaha serta masyarakat pada umumnya. Metode yang digunakan dalam kegiatan ini adalah dalam bentuk workshop teknologi pembuatan campuran bata beton dan edukasi yang melibatkan kelompok usaha, perangkat desa dan mahasiswa. Melalui kegiatan pengabdian ini diperoleh teknologi campuran yang menghasilkan produk bata beton yang berkualitas serta memenuhi Standard Nasional Indonesia. Namun demikian masih perlu dilakukan kontrol terkait kualitas pasir yang digunakan, rasio campuran semen:pasir dan metode pelaksanaan campuran oleh tenaga kerja yang dilatih. Melalui edukasi pengelolaan usaha, keterampilan anggota kelompok dalam menyusun laporan keuangan meningkat sebesar 80% namun masih dibutuhkan pembinaan lanjutan terkait manajemen pemasaran khususnya dengan teknologi digital. Diharapkan agar kegiatan ini dapat memperbaiki dan meningkatkan pendapatan kelompok usaha dan mendorong perbaikan nilai ekonomi dan sosial masyarakat. Produk bata beton dari limbah abu terbang dan metakaolin dapat menjadi produk unggulan desa yang meningkatkan kesejahteraan masyarakat dan peluang usaha di Kabupaten Minahasa Tenggara.