bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of IoT technology based on ambient light sensing in intelligent elderly care and rehabilitation service management system
Authors: Liang Shixin , Li Dawei 
Published: January 2024

Abstract

Currently, China is facing the challenge of an aging population, and chronic diseases have a serious negative impact on the physical health of the elderly, leading to enormous difficulties in seeking medical treatment, which has become a major challenge in an aging society. In addition, China currently lacks specialized elderly care and rehabilitation service platforms targeting the elderly population, which cannot meet the growing personalized needs of elderly patients. Therefore, we utilized advanced IoT technology based on object recognition algorithms to construct a network model of object recognition algorithms, conducted experimental testing, and ultimately designed an intelligent elderly care and rehabilitation service management system. The system has multiple functions such as health detection and emergency calls, and its feasibility has been verified through network testing. After testing, this system can effectively monitor falls in the elderly in a timely manner, as well as record and analyze changes in the elderly's physical condition in real-time. A new model and solution for providing intelligent elderly care and rehabilitation services for the elderly not only improves the content of intelligent home care and rehabilitation services, but also improves the drawbacks of traditional elderly care services, reduces the pressure on caregivers, improves monitoring accuracy, and improves service quality.
Application of Interactive Artificial Intelligence System Based on Image Detail Enhancement Algorithm in Clothing Graphic Design
Authors: Ma Tingting 
Published: January 2024

Abstract

With the continuous improvement of the aesthetic quality of the modern society, the demand for fashion is rapidly growing, and more and more users are beginning to experience the independent design and customization of fashion clothing. The development and progress of digital and intelligent technologies provide opportunities to address the challenges of interactive artificial intelligence in clothing graphic design processes. Therefore, this article studies interactive artificial intelligence systems using image detail enhancement algorithms and analyzes their application in clothing graphic design. Firstly, using adaptive configuration and detail enhancement algorithms to improve image quality and improve the matching effect of feature points, and conducting experiments on the improvement index and global contrast index through evaluation indicators to examine the feasibility of the algorithm proposed in this paper; Secondly, the clothing graphic design algorithm was studied, and the feature database samples were tested using the clothing graphic design algorithm to demonstrate the relationship between classification accuracy and the number of cycles; Finally, construct an interactive artificial intelligence system, study the application of interactive artificial intelligence systems in clothing graphic design, and propose a clothing pattern communication platform. Further proves that interactive artificial intelligence systems based on image detail enhancement algorithms have high application value in clothing graphic design.
A Weather-Resilient Electronic Circuit Breaker (ECB) for Enhanced Electrical Safety and Efficiency
Authors: Habib Muhammad Irfan 
Published: January 2024

Abstract
This research paper is aimed at proposing a cost-effective, innovative Electronic Circuit Breaker (ECB) that rectifies the weaknesses found in typical circuit breakers – especially during cold seasons. Traditional opposite parts usually suffer from sluggish response times and inefficiencies, more particularly under the conditions of low amperage which can cause burning and other damages to electrical household equipments. The concept ECB solves these problems, while also providing functionality to work in all seasons – both summer and cold weather with an optimal response time. This advanced ECB novel idea will provide enhanced protection measures on devices that use low current, consequently suppressing dangers represented by traditional circuit breakers. The study describes the experimental stages are described meticulously providing a comprehensive view of how ECB successfully works under various weather conditions. The findings furthermore not only reveal their impressive performance, but also enhance the discussion by exploring postulated reasons, operational models and suitable comparisons with studies in existence. Simply put, the above described ECB is a significant advance in development of circuit breaker technology and demonstrates a considerable safety improvement as well efficiency increase and cost-effectiveness. This innovation has the potential to solve long-standing issues related to traditional circuit breakers and open the door for modern, better electrical systems and improved device protection.
Variability of the surface boundary layer of reef-building coral species
Authors: Martins Catarina P. P. , Wall Marlene , Schubert Patrick , Wilke Thomas , Ziegler Maren 
Published: January 2024

Abstract
The coral-seawater interface is an important, highly dynamic microenvironment for reef-building corals. Also known as the concentration boundary layer (CBL), it is a thin layer of seawater bordering the coral surface that dictates the biochemical exchange between the coral colony and bulk seawater. The CBL is thus a key feature that modulates coral metabolism. However, CBL variation among small-polyped coral species remains largely unknown. Therefore, we recorded over 100 profiles of dissolved O2 concentration using microsensors to characterise CBL traits (thickness, surface O2 concentration, and flux) of three small-polyped branching coral species, Acropora cytherea, Pocillopora verrucosa, and Porites cylindrica. Measurements were conducted during light and darkness combined with low or moderate water flow (2 and 6 cm s-1). We found that CBL traits differed among species. CBL thickness was lowest in A. cytherea, while P. verrucosa showed the largest depletion of surface O2 in dark and highest dark flux. In addition, we found that O2 concentration gradients in the CBL occurred with three main profile shapes: diffusive, S-shaped, and complex. While diffusive profiles were the most common profile type, S-shaped and complex profiles were more frequent in P. verrucosa and P. cylindrica, respectively, and prevailed under low flow. Furthermore, profile types differed in CBL thickness and flux. Finally, low flow thickened CBLs, enhanced changes in surface O2 concentration, and reduced flux, compared to moderate flow. Overall, our findings reveal CBL variability among small-polyped branching corals and help understand CBL dynamics in response to environmental changes.
Intracellular bactericidal activity of MDP1 antimicrobial peptide against VRSA and MRSA in human endothelial cells
Authors: Dashtbin Shirin , Razavi Shabnam , Barneh Farnoosh , Ekhtiari-Sadegh Sarvenaz , Irajian Gholamreza , Bagheri Kamran Pooshang 
Published: January 2024

Abstract
Background
Staphylococcus aureus (S. aureus) acts as a major causative agent of postoperative infections by thriving within host cells leading to persistent and chronic infections. The limited efficacy of conventional antibiotics against intracellular S. aureus is attributed to their inability to penetrate host cells. In this study, we evaluated a cell-penetrating peptide, MDP1, which was derived from melittin for the purpose of eliminating S. aureus. This study aimed to assess the bactericidal effectiveness of the cationic antimicrobial peptide MDP1 against intracellular S. aureus. S. aureus infection model was employed to evaluate MDP1's efficacy in eliminating intracellular S. aureus.
Methods
The most pathogenic clinical isolates of Vancomycin- and Methicillin-resistant S. aureus (VRSA and MRSA) which express high level of fibronectin binding protein A were selected by real-time PCR. Internalization of the bacteria into endothelial cell model was proved by culture and transmission electron microscopy (TEM).
Results
In vitro assessments revealed potent antibacterial characteristics, indicating that MDP1 is efficacious in eliminating intracellular VRSA and MRSA in the cells; proved by culture and fluorescent microscopy.
Conclusions
These findings indicate that the innovative MDP1 antimicrobial peptide could serve as a viable therapeutic for eradication of intracellular bacterial infections. Our results suggest that more novel approaches to targeted therapy might be developed by the targeting of antimicrobial peptides to endothelial receptor.
Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis
Authors: YUSOFF ZAKIAH MOHD , NURLAILA  , Huzir Siti Mariatul Hazwa Mohd , NORDIN SITI AMINAH 
Published: January 2024

Abstract
This bibliometric article investigates the burgeoning research landscape surrounding Agarwood oil, derived from the Aquilaria tree species. The historical and cultural significance of Agarwood, coupled with its diverse applications in perfumery, traditional medicine, and religious practices, has fueled a surge in scientific interest. However, a comprehensive understanding of the current state of Agarwood oil research is lacking. This study addresses this gap through a systematic review and bibliometric analysis of scholarly databases. By employing techniques such as co-citation analysis and keyword co-occurrence, the research aims to quantify patterns, relationships, and collaborations within the literature. The methodology involves a focused exploration of a specified timeframe to capture recent developments, with the anticipation that the outcomes will include the identification of key contributors, thematic clusters, and emerging trends in Agarwood oil research. The study is poised to contribute valuable insights for researchers, policymakers, and industry stakeholders, offering a holistic perspective on the interconnectedness of Agarwood oil research and guiding future exploration in this dynamic field.
Responsible Tourism Development-A Systematic Review &amp; Bibliometric Analysis
Authors: Pattiyagedara Shashika Shyamali 
Published: January 2024

Abstract
As wider consumer trends toward lifestyle marketing and ethical consumerism spread to the travel and tourist industry, responsible tourism has become an essential market trend worldwide. Through articles published between 2002 and 2023, this study investigates, compiles, and synthezes the empirical research on the evolution of responsible tourism. Systematic literature review (SLR) methodology and preferred reporting items for systematic reviews and Meta analysis (PRISMA) guidelines were used to address the research objective with bibliometric analysis, employing VOS viewer software. Findings revealed key phrases in scientific publications predominantly on Responsible Tourism development, 71 articles were included from Lens.ORG, Emarald Insight and Google scholar databases and all were formatted for Lens.ORG. The study found two areas of outcomes and means for responsible tourism development. (1) Economic Development related outcomes (2) Sustenance of tourism-based outcomes. The findings imply that future study trends should focus on sustenance-based outcomes as the responsible tourism development.
Paeoniflorin alleviates neuroinflammatory response by suppressing HMGB1/RAGE pathway activation in MPTP induced mouse PD model
Authors: Liu Yezu , Peng Shijun , Wang Lepeng , Liu Ruen 
Published: January 2024

Abstract
Background
Numerous studies have highlighted that Paeoniflorin (PF) exerts various biological effects, including anti-inflammatory, antioxidative, and anti-apoptotic actions on Parkinson’s disease (PD). However, the underlying anti-inflammatory mechanism of PF on PD is still not fully understood.
Methods
In present study, we assumed that the neuroprotective effect and anti-inflammatory mechanism of PF occurs through modulating HMGB1/RAGE pathway. We verified this hypothesis on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)/1-Methyl-4-Phenylpyridinium Iodide (MPP+) induced PD model of mice and BV-2 cells. We performed behavioral tests (pole test, beam-cross test and traction test) to investigate the motor function, the protein level of tyrosine hydroxylase (TH) and the aggregation of microglia were evaluated by immunostaining. The pro-inflammatory cytokines and the expression of HMGB1, RAGE, and NF-κB were evaluated via ELISA and Western blot analyses respectively.
Results
The results showed that PF treatment could significantly improve motor function of PD mice in behavioral tests. Our data also revealed that PF could rescue dopamine neuron loss, inhibit the aggregation of microglial cells in the substantia nigra pars compacta in immunostaining, and lower the levels of pro-inflammatory cytokines in ELISA test. Both in vitro and in vivo experiments demonstrated that PF downregulates the expression of HMGB1, RAGE, and NF-κB in the PD models induced by MPTP/MPP+.
Conclusion
In this study, PF exerted neuroprotective effects on PD models by downregulating the activation of HMGB1/RAGE/NF-κB pathway to reduce neuroinflammatory response.
Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs
Authors: Kyrkou Ifigeneia , Bartell Jennifer , Lechuga Ana , Lood Cédric , Marvig Rasmus Lykke , Lavigne Rob , Molin Søren , Johansen Helle Krogh 
Published: January 2024

Abstract

Pseudomonas aeruginosa is a bacterium with increasing relevance in clinical settings and among the most common bacteria occupying the cystic fibrosis (CF) lung niche. Its ability to colonize and persist in diverse niches is attributed to this bacterium’s large accessory genome. In P. aeruginosa, prophages represent a common feature of a strain’s accessory genome. Hence, we hypothesized that prophages play a role in the bacterium’s fitness and persistence in CF. We focused on the CF niche and used longitudinal isolates of patients persistently infected by P. aeruginosa. Via in silico analysis we predicted intact prophages in the genomes of each longitudinal isolate group and scored their long-term persistence. We then confirmed whether they are inducible and where they reside by induction experiments and lysate sequencing. Lastly, we performed comparative genomics to evaluate prophage diversity and confirm their predicted long-term persistence and level of genomic maintenance. In concurrence with other studies, our findings support that most P. aeruginosa harbour prophages, some of which can self-induce. We also found ciprofloxacin, an antibiotic commonly used for P. aeruginosa treatment in CF, to induce prophages. The induced prophage genomes displayed a high degree of diversity and instances of genomic novelty. Finally, we discovered that all induced prophages persisted long-term with their genomes virtually unchanged, suggesting that they likely assist host persistence. In addition to elucidating the role of prophages in P. aeruginosa, we expect our findings to aid in developing novel diagnostics and phage-based therapies for P. aeruginosa infections.
Divergent molecular strategies drive convergent evolutionary adaptation to kin competition in biofilms
Authors: Tang Mingxing , Yang Ruixue , Han Shuhong , Zhuang Zilin , Li Peiyu , Fan Kewei , Cai Zhao , Yang Qiong , Yu Zhijian , Yang Liang , Li Shuo 
Published: January 2024

Abstract
Biofilms are a hotspot of bacterial social interactions that are characterized by cooperation and competition. Even a mono-species biofilm would evolve and diversify into polymorphic subpopulations so that bacterial kins of different genotypes would compete for limited nutrient and space. However, the specific biological functions underlying biofilm diversification and competition adaptation are poorly demonstrated. Here, we launched and monitored the experimental evolution of Pseudomonas aeruginosa biofilms, finding that two competition-adaptive derivatives rapidly emerged with variable capacities in forming biofilm. Further investigations identified that two novel divergent molecular trajectories were adopted for convergent adaptation to kin competition: one involved hijacking bacteriophage superinfection to aggressively inhibit kin competitors, while the other induced a subtle change in c-di-GMP signaling to gain a positional advantage via enhanced early biofilm adhesion. Bioinformatics analyses implicated that similar evolutionary strategies were prevalent among clinical P. aeruginosa strains, indicative of parallelism between natural and experimental evolution. Divergence in the molecular bases illustrated the adaptive values of genomic plasticity for gaining competitive fitness in the biofilm. Finally, we demonstrated that these competition-adaptive mutations reduced bacterial virulence. Our findings showed how kin competition shaped the P. aeruginosa biofilm evolution. More importantly, it revealed new insights into molecular targets for the treatment of recalcitrant biofilm infections formed by this clinically relevant pathogen.
Cryptocurrency Impact on India’s Monetary Policy
Authors: Sharma Apica 
Published: January 2024

Abstract
This study uses the Structural Factor Augmented VAR in exogenous variables (SFAVARx) approach to analyse the impact of cryptocurrency transactions on India’s major macroeconomic variables. Monthly data from May 2013 to October 2021 are sourced from the Reserve Bank of India and statista.com. The current form of cryptocurrency did not have a significant impact on inflation, production, the money supply, or major interest rates. However, given the increasing marginal participation in the crypto market, these important macroeconomic variables can be adversely affected in the future. The Central Bank Digital Currency (CBDC) with features related to India is being proposed as a proactive measure.
Etiology and differential diagnosis of binocular diplopia in comitant and incomitant strabismus
Authors: Proskurina O. V. , Tarutta E. P. , Khvedelidze T. Z. , Harutyunyan S. G. , Aklaeva N. A. , Apaev A. V. 
Published: January 2024

The article discusses the main etiological factors in the development of binocular diplopia and differential diagnostic signs of diplopia induced by late acquired comitant and incomitant strabismus.Purpose:to identify the most common causes of binocular diplopia in adults, and to assess typical features of various etiologies of binocular diplopia.Material and methods.168 patients with binocular diplopia aged 6.5 to 85 years received a complete ophthalmological examination, which included a qualitative evaluation and characterization of the nature of diplopia, and determination of eye mobility in eight directions of gaze which indicated the affected muscle. A numerical assessment of diplopia was done using a prismatic compensator.Results.In 66.7% of cases, diplopia was induced by comitant strabismus, predominantly (96.4%) the converging one. A comitant strabismus with a small angle was observed more frequently than one with a larger angle: 5° or less, in 50% of cases, and 10° or less in 25% of cases. In 64.3% of cases, the deviation angle did not conform with the value of the compensating prism, which turned out to be twice as high as the “calculated values”. In 79.5% of cases, diplopia induced by comitant strabismus developed before the age of 45. In 33.3% of cases, diplopia was induced by incomitant strabismus, with the deviation angle varying from 0 to 35°, different directions of eye deviation, and limitation of mobility. In 44.6% of cases, mobility restrictions could not be visually detected. The deflection angle conformed to the strength of the compensating prism. In 58.9% of cases, diplopia induced by incomitant strabismus developed at the age of 45 years and older.Conclusion.Diplopia frequently develops in young and middle-aged people. The most common cause of the development of diplopia is a late acquired comitant converging strabismus with a small angle (5° or less), which develops in parallel with myopia. A correct identification of strabismus nature (comitant vs. incomitant), which induces diplopia, contributes to optimally choosing a further tactics for diplopia elimination.
Cattle wastewater treatment using green microalga Coelastrella sp. KNUA068 as a promising bioenergy feedstock with enhanced biodiesel quality
Authors: Suh Ho-Seong , Do Jeong-Mi , Yeo Hee-Tae , Yoon Ho-Sung 
Published: January 2024

Abstract
Global water scarcity increased the demand for clean water, leading to attention on microalgae-based biological treatment for wastewater due to economic feasibility and sustainable biomass applications. This study isolated indigenous microalga Coelastrella sp. KNUA068 from a wastewater treatment plant, observed its admissible growth rate in diluted cattle wastewater (DCW), and used it for wastewater treatment analysis. The microalga showed high growth rates in indoor and outdoor cultivation with 100% DCW. In addition, the ammonia nitrogen and nitrate nitrogen removal rates of the microalga were 69.97 and 60.35%, respectively, in indoor cultivation, and 50.63 and 67.20%, respectively, in outdoor cultivation. Carotenoid content analysis revealed lutein as the highest productivity carotenoid, and zeaxanthin production was higher in outdoor cultivation. The biomass exhibited suitable biodiesel quality with a cetane number of 50.8 for high-quality biodiesel production. Coelastrella sp. KNUA068 demonstrates potential for bioenergy feedstock, carotenoid production, and wastewater treatment.
Tumor Immunotherapy–Related Information on Internet-Based Videos Commonly Used by the Chinese Population: Content Quality Analysis
Authors: Ni Chen-xu , Fei Yi-bo , Wu Ran , Cao Wen-xiang , Liu Wenhao , Huang Fang , Shen Fu-ming , Li Dong-jie 
Published: January 2024

Background
Tumor immunotherapy is an innovative treatment today, but there are limited data on the quality of immunotherapy information on social networks. Dissemination of misinformation through the internet is a major social issue.

Objective
Our objective was to characterize the quality of information and presence of misinformation about tumor immunotherapy on internet-based videos commonly used by the Chinese population.

Methods
Using the keyword “tumor immunotherapy” in Chinese, we searched TikTok, Tencent, iQIYI, and BiliBili on March 5, 2022. We reviewed the 118 screened videos using the Patient Education Materials Assessment Tool—a validated instrument to collect consumer health information. DISCERN quality criteria and the JAMA (Journal of the American Medical Association) Benchmark Criteria were used for assessing the quality and reliability of the health information. The videos’ content was also evaluated.

Results
The 118 videos about tumor immunotherapy were mostly uploaded by channels dedicated to lectures, health-related animations, and interviews; their median length was 5 minutes, and 79% of them were published in and after 2018. The median understandability and actionability of the videos were 71% and 71%, respectively. However, the quality of information was moderate to poor on the validated DISCERN and JAMA assessments. Only 12 videos contained misinformation (score of >1 out of 5). Videos with a doctor (lectures and interviews) not only were significantly less likely to contain misinformation but also had better quality and a greater forwarding number. Moreover, the results showed that more than half of the videos contain little or no content on the risk factors and management of tumor immunotherapy. Overall, over half of the videos had some or more information on the definition, symptoms, evaluation, and outcomes of tumor immunotherapy.

Conclusions
Although the quality of immunotherapy information on internet-based videos commonly used by Chinese people is moderate, these videos have less misinformation and better content. Caution must be exercised when using these videos as a source of tumor immunotherapy–related information.