bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory role of miRNAs on Wnt/β-catenin signaling in tumorigenesis of glioblastoma
Authors: Rahmani Farzad , Hashemian Pedram , Tabrizi Ayda Tadayyon , Ghorbani Zeynab , Ziaeemehr Aghigh , Alijannejad Sajede , Ferns Gordon A , Avan Amir , Shahidsales Soodabeh 
Published: September 2023

Abstract
Glioblastoma (GBM) is one of the most aggressive tumors in the brain with high mortality worldwide. Despite recent advances in therapeutic strategies, the survival rate remains low in patients with GBM. The pathogenesis of GBM is a very complicated process involving various genetic mutations affecting several oncogenic signaling pathways like Wnt/β-catenin axis. Overactivation of the Wnt/β-catenin signaling pathway is associated with decreased survival and poor prognosis in patients with GBM. MicroRNAs (miRNAs) were shown to play important roles in the regulation of cell proliferation, differentiation, apoptosis, and tumorigenesis by modulating the expression of their target genes. Aberrant expression of miRNAs were reported in various human malignancies including GBM, breast, colorectal, liver, and prostate cancers, but little is known about their cellular mechanisms. Therefore, recognition of the expression profile and regulatory effects of miRNAs on the Wnt/β-catenin pathway may offer a novel approach for the classification, diagnosis, prognosis, and treatment of patients with GBM. This review summarizes previous data on the modulatory role of miRNAs on the Wnt/β-catenin pathway implicated in tumorigenesis of GBM.
Evaluation of Serum Zinc Levels in Type 2 Diabetes Mellitus Patients and its Correlation with Glycosylated Hemoglobin and Overt Diabetic Complications
Authors: Bhiwgade Rahul Dilip , Bitey Shobhana Amol , Bitey Amol , Hiwarkar Suraj Ramesh 
Published: September 2023

Abstract

Background:
Diabetes mellitus is the most prevalent disease in worldwide. It is characterized by hyperglycemia, insulin resistance, and relative insulin deficiency. The goal of this study is to estimate serum zinc levels in type 2 diabetes mellitus patients and correlation between serum zinc levels, glycosylated hemoglobin (HbA1c) levels, and complications in type 2 diabetes patients.

Aims and Objectives:
To estimate serum zinc levels in patients with type 2 diabetes mellitus, study correlation between serum zinc levels and HbA1c levels, and compare serum zinc levels, HbA1c, and overt diabetic complications.

Materials and Methods:
This prospective observational study was conducted in a tertiary center. Diagnosed 100 cases of type 2 diabetes mellitus were taken and detailed examination was done. Serum zinc levels were estimated by absorption spectrophotometry, and HbA1c levels were estimated using high-performance liquid chromatography method. Statistical software STATA version 14.0 was used for data analysis.

Results:
The mean age of the patients was 49.6 ± 11.18 years with a male: female ratio of 2.1:1. Mean serum zinc levels in males with macrovascular complications were 43.65 ± 14.55 μg/dl, significantly lower than the mean serum zinc levels in females 67.31 ± 18.84 μg/dl, P < 0.0001. Serum zinc levels were low in patients with microvascular complications and macrovascular complications, which were statistically significant P < 0.0001 and an inverse correlation was observed between HbA1c levels and serum zinc levels (r = −0.4456, P < 0.0001).

Conclusion:
Low serum zinc levels associated with micro- and macrovascular complications of diabetes mellitus. This study revealed an inverse relationship between HbA1c and serum zinc concentration in type 2 diabetes mellitus patients.
Prevalence of Nonalcoholic Fatty Liver Disease in Hypothyroid Subjects: A Cross-sectional Comparative Study
Authors: Patel Maharshi , Acharya Sourya , Kumar Sunil 
Published: September 2023

Abstract

Background:
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. NAFLD has become the leading cause of liver disease globally. Hypothyroidism is a major factor in the development of NAFLD. Thus, the current investigation aimed to estimate the prevalence of NAFLD in individuals with hypothyroidism.

Materials and Methods:
This cross-sectional comparative study was conducted on 142 patients who qualified for the eligibility criteria. Proper history, examination, anthropometric measurements, and biochemical parameters were estimated. The collected data were entered in Excel and analyzed using the Statistical Package for Social Science 25 version developed by IBM (International Business Machine), IBM is a USA based company and the Student’s t-test and the Chi-square test were applied.

Results:
In this study, 12.6% of the treated subjects had fatty liver and 59.15% of the untreated subjects had fatty liver. From these untreated cases, fatty liver was found in 17.6% of subclinical hypothyroid subjects and 41.5% of overt hypothyroid subjects. There was a significant association between thyroid status and fatty liver (χ2 = 68.046, P < 0.001).

Conclusions:
We have found that NAFLD is more prevalent in untreated hypothyroid subjects. The severity of NAFLD is more in patients with overt hypothyroidism. Early treatment with thyroxine can prevent the progression of the fatty liver and grave consequences such as nonalcoholic steatohepatitis and cirrhosis.
Evaluation of Electrocardiographic Repolarization Parameters in Patients who Received Ribociclib and Palbociclib Therapy
Authors: Erdal Gülçin Sahingöz , Karabulut Dilay , Yildiz Cennet , Isiksacan Nilgun , Oflar Ersan , Çaglar Fatma Nihan Turhan , Pirhan Osman , Sinoplu Hasan Ali , Katkat Fahrettin , Tural Deniz 
Published: September 2023

Abstract

Introduction:
Ribociclib and palbociclib are the inhibitors of cyclin-dependent kinase (CDK) 4/6 activity which have been used in the treatment of metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2-negative breast cancer. QT interval prolongation has been the main reported adverse effect in Phase III trials of ribociclib and palbociclib therapy. In the present study, we aimed to evaluate electrocardiographic (ECG) changes in patients who received palbociclib and ribociclib therapy.

Materials and Methods:
Sixty women with metastatic HR-positive, human epidermal growth factor-2-negative breast cancer were included in the study. Baseline ECG and echocardiographic examinations of these patients were done. Second control electrocardiogram was obtained on the 14th day of first-cycle therapy. PR interval, corrected QT (QTc) interval, QT dispersion (QTD), and QRS duration were calculated.

Results:
Heart rate, PR interval, QRS, QT, QTc, QTD, and corrected QTD duration did not differ before and after CDK 4/6 treatment. Two patients who received ribociclib and palbociclib treatment had basal QTc duration higher than 450 ms (458 ms and 465 ms, respectively). The 14th-day QTc intervals of these patients were found to be 318 ms and 406 ms, respectively. After CDK 4/6 treatment, only two patients had QTc interval of 469 ms and 507 ms. The mean change of QTc interval before and during the 14th day of CDK 4/6 therapy was 7.38 ± 35.049 ms. When palbociclib and ribociclib treatments were analyzed separately, the baseline and 14th day of QTc interval were 415 ± 31.5 versus 428.11 ± 24.52 and 416.13 ± 26.05 versus 420.07 ± 31.32 ms, respectively.

Conclusions:
Ribociclib and palbociclib treatment was associated with a small statistically insignificant increase in QTc interval. Physicians should be aware of the side effect of these treatments.
Indian art critic and artist Om Chand Handa: main directions of creativity
Authors: Белокурова С.М. 
Published: September 2023

Статья посвящена творчеству известного индийского историка, культуролога Ом Чанд Ханды. Автор ставит целью ввести новый материал в оборот отечественной науки, поскольку труды профессора Ханды до 2015 года не публиковались в России. В статье рассматривается спектр научных интересов, методология исследовательской деятельности ученого, дается обзор нескольких статей и монографий, а также краткие биографические сведения. Автор статьи отдельно останавливается на творческой стороне работы профессора Ханды, который сопровождает исследования собственными графическими иллюстрациями. Анализируются несколько графических листов из альбома «Glimpses of Western Himalaya. Pen Drawings and Description of Majestic Mountains, Verdant Valleys and Marvelous Monuments» с точки зрения их художественной насыщенности, композиционной выразительности и технического мастерства. В заключение делается вывод о том, что Ом Чанд Ханда представляет собой яркий пример синтетической личности ученого-художника, имеющего два уровня восприятия произведения искусства: логический и эмоциональный, которые не соперничают между собой, но дополняют друг друга.
The article is devoted to the work of the famous Indian historian and cultural scientist Om Chand Handa. The author aims to introduce new material into the circulation of domestic science, since the works of Professor Handa were not published in Russia until 2015. The article examines the range of scientific interests of the scientist, the methodology of his research activities, provides an overview of several articles and monographs, as well as brief biographical information about the scientist. The author of this article dwells specifically on the creative component of the work of Professor Handa, who accompanies the research with his own graphic works. The article analyses several graphic sheets from the album “Glimpses of Western Himalaya. Pen Drawings and Description of Majestic Mountains, Verdant Valleys and Marvellous Monuments” in terms of their artistic richness, compositional expressiveness and technical skill. In conclusion, it is concluded that the work of Om Chand Handa is a vivid example of the synthetic personality of a scientist-artist who has two levels of perception of a work of art: logical and emotional, which do not compete with each other, but complement each other.
Artistic forms of the Siberian Ice Age as a way of self-identification of man and society: objects of personal ornamentation
Authors: Лбова Л.В. 
Published: September 2023

Исследование древнейших форм мобильного искусства ледниковой эпохи в Сибири позволяет в составе археологических коллекций выделить три группы предметов: персональные (личные) украшения, предметы престижного характера (предметы обмена в том числе), коллекцию объемной скульптуры (антропоморфные и зооморфные образы). Гипотезы, которые ранее предлагались исследователями об эстетической, хозяйственно-бытовой, магико-ритуальной и т. д. функциях древнейшего мобильного искусства (артефактов с признаками художественного творчества), продолжают развиваться на основе новых инструментальных и когнитивных возможностей. В статье предлагается гипотеза понимания предметов личной (персональной орнаментации, или «украшения») как способа самоидентификации или самоописания человека и сообщества. Исследования построены на результатах технико-морфологического, типологического, микроскопического анализа предметов, а также последующих кросскультурных аналогий. Мультидисциплинарные исследования мобильной пластики древнейшего искусства из археологических и этнографических музейных коллекций Сибири и Дальнего Востока представляют возможности реконструкции таких форм творчества как свидетельств самоидентификации (гендерной, социальной, этнокультурной).
Research of the oldest forms of Prehistory portable art of the Ice Age in Siberia allows to distinguish three groups of objects: personal jewellery, objects of prestigious character (objects of exchange including), collection of volumetric sculpture (anthropomorphic and zoomorphic images). Hypotheses that were previously proposed by researchers about the aesthetic, household, magic-ritual, etc. functions of the Prehistory portable art (artifacts with signs of artistic creativity) continue to develop on the basis of new instrumental and cognitive capabilities. The paper proposes a hypothesis of understanding personal objects (personal ornamentation, or “decoration”) as a way of self-identification or self-description of a person and a community. The research is based on the results of technical-morphological, typological, microscopic analysis of objects, and subsequent cross-cultural analogies. Multidisciplinary studies of the mobile plastics of Prehistory art from the archaeological and ethnographic museum collections of Siberia and the Far East present the possibility of reconstructing such forms of creativity as evidence of self-identification (gender, social, ethno-cultural).
Idealization in art
Authors: Иванов А.В. 
Published: September 2023

В статье анализируется понятие идеализации. Разбираются различные смыслы, которые в него вкладываются. Особое внимание уделяется истолкованию идеализации в немецкой классической философии, особенно в философском наследии Шеллинга. По Шеллингу, процесс идеализации подразумевает художественное постижение и выражение идеальной сущности вещей, людей и событий через ее явленность в образно-символической форме. Идеализация противостоит, с одной стороны, натурализму в искусстве, а с другой, рационалистическим идеализациям действительности в смысле ее приукрашивания. Показывается присутствие художественной идеализации в различных жанрах изобразительного искусства: натюрморте, пейзаже, портрете, исторических полотнах.
The article analyses the concept of idealization. The various meanings that are put into it are being analysed. Special attention is paid to the interpretation of idealization in German classical philosophy, especially in Schelling’s philosophical heritage. According to Schelling, the process of idealization implies comprehension and artistic discovery of the ideal essence of things, people and events through its manifestation in figurative and symbolic form. Schelling's idealization opposes, on the one hand, naturalism in art, and, on the other, its rationalistic idealizations of reality in the sense of its embellishment. It is shown the existence of artistic idealization in various genres of fine arts: still-life, landscape, portrait, historical canvases.
Expressionism in painting: philosophical reflections
Authors: Фотиева И.В. 
Published: September 2023

Статья посвящена философским аспектам экспрессионизма в живописи первой половины XX века. Рассмотрены истоки и предшественники экспрессионизма, философские школы и основные идеи, на которые опирались представители данного направления, показано их своеобразное преломление в работах теоретиков экспрессионизма и в произведениях ведущих художников. Выявлены различные и часто противоречивые интерпретации ряда основных идей, в том числе идеи единства мира и роли чувства в художественном творчестве. Отмечено, что само стремление экспрессионистов понять природу художественного творчества, сущность и специфику искусства; осознать его место не только в рамках человеческой культуры, но и самого Бытия заслуживает внимания и что многие вопросы, поднятые экспрессионистами, сегодня незаслуженно ушли на второй план в исследованиях не только искусствоведов, но и представителей философии искусства, хотя здесь огромное пространство для дальнейших исследований.
The article is devoted to the philosophical aspects of the expressionism in painting in the first half of the 20th century. The origins and predecessors of expressionism, philosophical schools and the main ideas on which the representatives of this direction relied are considered. Their peculiar refraction in the works of the theorists of expressionism and in the works of leading artists is shown. Various and often contradictory interpretations of a number of basic ideas are revealed, including the idea of the unity of the world and the role of feeling in artistic creativity. It is noted that the very desire of expressionists to understand the nature of artistic creativity, the essence and specificity of art; to realize its place not only within the framework of human culture, but also of Being itself deserves attention. Many questions raised by expressionists today have undeservedly gone by the wayside in the studies of not only art historians, but also representatives of the philosophy of art, although there is a huge space for further research.
Deep Sand God
Authors: Чандра Л. 
Published: September 2023

Статья посвящена иконографии Бога глубоких песков, гневного буддийского божества, защищавшего, согласно легенде, монаха Сюань-цзана в его путешествии по Центральной и Южной Азии. Приводятся изображения и тексты из Китайской Трипитаки, японского иконографического собрания «Дзёбодай сю» (Эйбан, 1094 г.), трактатов «Цзу-Энь чуань», «Сингон-миккё-зуин-сю», «Тан Сань-цзан чи», «Тем-бу-гё-дзо», «Дзузо-сё» (Ёгэн), «Бессон-закки» и «Сёсон-дзузо» (Синкаку), «Сикасё-дзузо» и «Асаба-сё» (Сёдзё), свитка Дайго-дзи, коллекции Какудзена, сведения из других источников. Перевод статьи Локеша Чандры из «Словаря буддийской иконографии» выполнен С.М. Белокуровой.
The article is devoted to the iconography of the God of Deep Sands, an angry Buddhist deity who, according to legend, protected the monk Hüan-tsang on his journey through Central and South Asia. The article presents images and texts from the Chinese Tripitaka, Japanese iconographic collection Jōbodai shū (by Eiban, 1094), treatises Tz’u-en chuan, Shingon-mikkyō-zu-in-shū, T’ang San-tsang chi, Tem-bu-gyō-zō, Zuzō-shō (by Yōgen), Besson-zakki and Shoson-zuzō (by Shinkaku), Shika-shō-zuzō and Asaba-shō (by Shōchō), scroll of Daigo-ji, collection of Kakuzen, and data from other sources. Translation of an article by Lokesh Chandra from the Dictionary of Buddhist Iconography by S.M. Belokurova.
The Moderating Role of Technology on the Link between Strategic Training and Performance of State Ministries: Perspectives from Kenya
Authors: Selline Indara , Henry Kegoro , Dina Otieno 
Published: September 2023

Purpose: The purpose of this study was to examine the moderating role of technology on the link between strategic training and performance of State ministries in Kenya. Human capital theory was utilized to inform this study.
Methodology: Cross-sectional research design was adopted in the collection and analysis of data. The study's target population was the 13 Kenyan government Ministries. The target population of the study consisted of 344 employees from 13 government ministries in Kenya. 185 respondents made up the study's sample size. To choose respondents, a stratified sample strategy was utilized. Structured questionnaires with both open and closed-ended questions were used to gather primary data. Acts of Parliament, service delivery charters, Vision 2030, session papers on public service delivery, and yearly performance reports were used to gather secondary data. Using experts in human resource management, the validity of the study instrument was assessed. The Cronbach Alpha formula, which adopted reliability coefficients of 0.7 as advised in literature, was used to assess reliability. Using the content analysis method, major themes from both written and spoken word were examined, and deductive arguments were produced based on the fundamental assumptions of the theories. Statistical Package for Social Sciences version 24 was used to perform the descriptive statistics, correlation, and regression analyses on the quantitative data. At a 95% confidence level and a 5% significance level, mean scores, standard deviations, percentages, and frequencies were utilized to define the components of each variable. Tables and graphics were used to present the examined data.
Findings: The findings of this study disclosed that strategic training had a significant positive effect on performance of government ministries in Kenya (r=.674, p-value=.000) while technology positively moderated the relationship between strategic training and performance of Kenyan government ministries (r=.672, p-value=.000). The study concluded that, if properly adopted, strategic training combined with technology can effectively explain performance of government ministries in Kenya.
Unique Contribution to Theory, Practice and Policy: This study recommends that for effective performance of government ministries in Kenya, embracing strategic training and technology is key. This study adds to theory by disclosing that managers can make decisions anchored on human capital theory as well as inform policies formulated and implemented.
ABORDAGENS EDUCACIONAIS BASEADAS NO USO DAS TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO: UMA PROPOSTA DE UTILIZAÇÃO DO LABORATÓRIO GEOGEBRA (LABGG) COMO FERRAMENTA PARA O ENSINO DE FUNÇÕES DO 2º GRAU
Authors: Jorge Lima Barbosa Antonio , Araújo Leal Débora 
Published: September 2023

A pesquisa tem por objetivo investigar o LABGG (Laboratório GeoGebra) para o ensino e aprendizagem de matemática, usando a ideia e o método desenvolvido na dissertação de Nascimento (2012), na qual o autor define como uma ferramenta psicopedagógica, com destaque os recursos que facilitam a integração e uso do programa com os conteúdos curriculares, professores e alunos. A metodologia presente será de cunho quantitativa, objetivando analisar o desempenho e a desenvoltura dos estudantes em um ambiente informatizado e verificar eventuais dificuldades relacionadas ao uso do programa e dificuldades relacionadas ao aprendizado de função, apontando possíveis soluções. Por último, a aplicação laboratorial na qual consta o estudo de funções do 2º grau e de um relato da pesquisa de campo na qual foram coletados argumentos de um questionário aplicado a 10 alunos do Ensino Fundamental matriculados em uma escola da Secretaria de Educação do Estado do Ceará (SEDUC) sobre análise do impacto na aplicação do Software livre GeoGebra no contexto de ensino da matemática.
Synthesis and structural characterization and DFT calculations of the organic salt crystal obtaining 9-aminoacridine and picric acid: 9-Aminoacridinium picrate
Authors: Aydin Fatma , Arslan Nahide Burcu 
Published: September 2023

Organic salt, 9-aminoacridinium picrate (9-AAcPc), containing equimolar quantities of 9-aminoacridine and picric acid was obtained and a single crystal was grown by the slow evaporation method in the mixture of methanol: tetrahydrofuran solvent (1: 1, v: v). The molecular structure of the prepared compound was confirmed by FT-IR, 1H NMR, and 13C NMR spectroscopic methods, as well as single crystal X-ray diffraction analysis. The X-ray diffraction analysis of the crystal structure of the title compound showed the presence of the triclinic space group P-1 with no. 2, a = 8.2811(7) Å, b = 10.1003(9) Å, c = 13.4484(13) Å, α = 83.521(3)°, β = 83.330(3)°, γ = 66.595(3)°, V = 1022.56(16) Å3, Z = 2, μ(MoKα) = 0.108 mm-1, Dcalc = 1.375 g/cm3, 56338 reflections measured (5.89° ≤ 2Θ ≤ 56.704°), 5097 unique (Rint = 0.0400, Rsigma = 0.0210) which were used in all calculations. The final R1 was 0.0552 (I > 2σ(I)) and wR2 was 0.1757 (all data). The molecular geometry was also optimized using density functional theory. The frontier molecular orbitals were calculated, and we discussed the probability that the proton transfers from the phenolic OH group of picric acid to different nitrogen units. The calculated electronic structure properties of the title molecule, such as the HOMO and LUMO analysis, and different molecular electrostatic potential maps, were obtained by using the density functional theory method, and the calculated structure was compared with the experimental structure. The thermal stability of the crystal was also analyzed using the TGA/DTG technique.