bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital staff reports of coworker positive and unprofessional behaviours across eight hospitals: who reports what about whom?
Authors: Urwin Rachel , Pavithra Antoinette , McMullan Ryan D , Churruca Kate , Loh Erwin , Moore Carolyn , Li Ling , Westbrook Johanna I 
Published: November 2023

BackgroundWorkplace behaviours of healthcare staff impact patient safety, staff well-being and organisational outcomes. A whole-of-hospital culture change programme, Ethos, was implemented by St. Vincent’s Health Australia across eight hospitals. Ethos includes a secure online submission system that allows staff across all professional groups to report positive (Feedback for Recognition) and negative (Feedback for Reflection) coworker behaviours. We analysed these submissions to determine patterns and rates of submissions and identify the coworker behaviours reported.MethodAll Ethos submissions between 2017 and 2020 were deidentified and analysed. Submissions include structured data elements (eg, professional role of the reporter and subjects, event and report dates) and a narrative account of the event and coworker behaviours. Descriptive statistics were calculated to assess use and reporting patterns. Coding of the content of submissions was performed to classify types of reported coworker behaviours.ResultsThere were a total of 2504 Ethos submissions, including 1194 (47.7%) Recognition and 1310 (52.3%) Reflection submissions. Use of the submission tool was highest among nurses (20.14 submissions/100 nursing staff) and lowest among non-clinical services staff (5.07/100 non-clinical services staff). Nurses were most frequently the subject of Recognition submissions (7.56/100 nurses) while management and administrative staff were the least (4.25/100 staff). Frequently reported positive coworker behaviours were non-technical skills (79.3%, N=947); values-driven behaviours (72.5%, N=866); and actions that enhanced patient care (51.3%, N=612). Medical staff were the most frequent subjects of Reflection submissions (12.59/100 medical staff), and non-clinical services staff the least (4.53/100 staff). Overall, the most frequently reported unprofessional behaviours were being rude (53.8%, N=705); humiliating or ridiculing others (26%, N=346); and ignoring others’ opinions (24.6%, N=322).ConclusionHospital staff across all professional groups used the Ethos messaging system to report both positive and negative coworker behaviours. High rates of Recognition submissions demonstrate a strong desire of staff to reward and encourage positive workplace behaviours, highlighting the importance of culture change programmes which emphasise these behaviours. The unprofessional behaviours identified in submissions are consistent with behaviours previously reported in surveys of hospital staff, suggesting that submissions are a reliable indicator of staff experiences.
Early Peanut Immunotherapy in Children (EPIC) trial: protocol for a pragmatic randomised controlled trial of peanut oral immunotherapy in children under 5 years of age
Authors: O'Sullivan Michael David , Bear Natasha , Metcalfe Jessica 
Published: November 2023

IntroductionFood allergy is a major public health challenge in Australia. Despite widespread uptake of infant feeding and allergy prevention guidelines the incidence of peanut allergy in infants has not fallen, and prevalence of peanut allergy in school-aged children continues to rise. Therefore, effective and accessible treatments for peanut allergy are required. There is high-quality evidence for efficacy of oral immunotherapy in children aged 4–17 years old; however, few randomised trials have investigated peanut oral immunotherapy (OIT) in young children. Furthermore, the use of food products for OIT with doses prepared and administered by parents without requiring pharmacy compounding has the potential to reduce costs associated with the OIT product.Methods and AnalysisEarly Peanut Immunotherapy in Children is an open-label randomised controlled trial of peanut OIT compared with standard care (avoidance) to induce desensitisation in children aged 1–4 years old with peanut allergy. n=50 participants will be randomised 1:1 to intervention (daily peanut OIT for 12 months) or control (peanut avoidance). The primary outcome is the proportion of children in each group with a peanut eliciting dose >600 mg peanut protein as assessed by open peanut challenge after 12 months, analysed by intention to treat. Secondary outcomes include safety as assessed by frequency and severity of treatment-related adverse events, quality of life measured using age-appropriate food allergy-specific questionnaires and immunological changes during OIT.EthicsThe trial is approved by the Child and Adolescent Health Service Human Research Ethics Committee and prospectively registered with the Australia and New Zealand Clinical Trials Registry.DisseminationTrial outcomes will be published in a peer-review journal and presented and local and national scientific meetings.Trial registration numberACTRN12621001001886.
Physical inactivity 5–8 years after anterior cruciate ligament reconstruction is associated with knee-related self-efficacy and psychological readiness to return to sport
Authors: Stigert Maja , Ashnai Farshad , Thomeé Roland , Hamrin Senorski Eric , Beischer Susanne 
Published: November 2023

ObjectivesTo investigate whether patient demographics and patient-reported outcomes (PROs), respectively, are associated with physical inactivity (PI) 5–8 years after primary anterior cruciate ligament reconstruction (ACLR).MethodsThis case control observational study included individuals who had undergone primary ACLR between the ages of 15 and 65 years and had responded to PROs 18 months postoperatively. These individuals were asked to answer a questionnaire regarding their present level of physical activity (PA) at 5–8 years after ACLR. Patient-demographic data and results from the Knee injury and Osteoarthritis Outcome Score, the Knee Self-Efficacy Scale and the ACL Return to Sport (RTS) after Injury scale from 18 months after ACLR were extracted from a rehabilitation-specific register. Univariable logistic regression analyses were performed with PI (<150 min PA per week/≥150 min PA/week) as the dependent variable.ResultsOf 292 eligible participants, 173 (47% women; mean±SD age = 31±11 years) responded to the PA questionnaire. In all, 14% (n=25; 28% women) were classified as physically inactive. Participants with lower levels of present and future self-efficacy, OR 1.35 (CI 1.05 to 1.72) and OR 1.20 (CI 1.12 to 1.45), and lower levels of psychological readiness to RTS, OR 1.19 (CI 1 to 1.43), at the 18-month follow-up, had higher odds of being physically inactive 5–8 years after ACLR. None of the patient demographic variables was able to predict PI.ConclusionLower levels of knee-related self-efficacy and psychological readiness to RTS, 18 months after ACLR, were associated with PI 5–8 years after surgery.
Eosinophilic myocarditis: systematic review
Authors: Techasatian Witina , Gozun Maan , Vo Kristine , Yokoyama Jennifer , Nagamine Todd , Shah Parthav , Vu Kimberly , Zhang James , Nishimura Yoshito 
Published: November 2023

ObjectiveIn clinical practice, patients with eosinophilic myocarditis (EM) may forgo the gold standard diagnostic procedure, endomyocardial biopsy (EMB), although it is highly recommended in guidelines. This systematic review aims to summarise current approaches in diagnosing and treating EM with a particular emphasis on the utilisation and value of alternative diagnostic methods.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, we searched MEDLINE and EMBASE for all peer-reviewed articles using the keywords “eosinophilic myocarditis” from their inception to 10 September 2022.ResultsWe included 239 articles, including 8 observational studies and 274 cases, in this review. The median patient age was 45 years. Initial presentations were non-specific, including dyspnoea (50.0%) and chest pain (39.4%). The aetiologies of EM were variable with the most common being idiopathic (28.8%) and eosinophilic granulomatosis polyangiitis (19.3%); others included drug-induced (13.1%) and hypereosinophilic syndrome (12.8%). 82.4% received an EM diagnosis by EMB while 17.6% were diagnosed based on clinical reasoning and cardiac MRI (CMR). CMR-diagnosed patients exhibited a better risk profile at diagnosis, particularly higher left ventricular ejection fraction and less need for inotropic or mechanical circulatory supports. Glucocorticoids were the primary treatment with variability in dosages and regimens.ConclusionEMB is the mainstay for diagnostic testing for EM. CMR is potentially helpful for screening in appropriate clinical scenarios. Regarding treatment, there is no consensus regarding the optimal dosage of corticosteroids. Large clinical trials are warranted to further explore the utility of CMR in the diagnosis of EM and steroid regimen in treating EM.
Approximating Sparsest Cut in Low-treewidth Graphs via Combinatorial Diameter
Authors: Chalermsook Parinya , Kaul Matthias , Mnich Matthias , Spoerhase Joachim , Uniyal Sumedha , Vaz Daniel 
Published: November 2023

The fundamental Sparsest Cut problem takes as input a graph
G
together with edge capacities and demands and seeks a cut that minimizes the ratio between the capacities and demands across the cuts. For
n
-vertex graphs
G
of treewidth
k
, Chlamtáč, Krauthgamer, and Raghavendra (APPROX’10) presented an algorithm that yields a factor-

\(2^{2^k}\)

approximation in time

\(2^{O(k)} \cdot n^{O(1)}\)

. Later, Gupta, Talwar, and Witmer (STOC’13) showed how to obtain a 2-approximation algorithm with a blown-up runtime of

\(n^{O(k)}\)

. An intriguing open question is whether one can simultaneously achieve the best out of the aforementioned results, that is, a factor-2 approximation in time

\(2^{O(k)} \cdot n^{O(1)}\)

.

In this article, we make significant progress towards this goal via the following results:

(i)

A factor-

\(O(k^2)\)

approximation that runs in time

\(2^{O(k)} \cdot n^{O(1)}\)

, directly improving the work of Chlamtáč et al. while keeping the runtime single-exponential in
k
.

(ii)

For any

\(\varepsilon \in (0,1]\)

, a factor-

\(O(1/\varepsilon ^2)\)

approximation whose runtime is

\(2^{O(k^{1+\varepsilon }/\varepsilon)} \cdot n^{O(1)}\)

, implying a constant-factor approximation whose runtime is nearly single-exponential in
k
and a factor-

\(O(\log ^2 k)\)

approximation in time

\(k^{O(k)} \cdot n^{O(1)}\)

.

Key to these results is a new measure of a tree decomposition that we call
combinatorial diameter
, which may be of independent interest.
Biology of the Endemic Endangered Swallowtail Butterfly, Papilio desmondi teita (Lepidoptera: Papilionidae), on Wild Citrus Species in Taita Hills, Kenya
Authors: Genga Oliver C. , Samita Namikoye E. , Kahuthia-Gathu Ruth , Kioko Esther N. 
Published: November 2023

The Taita Hills swallowtail butterfly, Papilio desmondi teita, was reared in captivity on wild citrus (Rutaceae), Toddalia asiatica and Clausena anisata, in Ngangao Forest, Taita Hills, Kenya. The butterflies were exposed to the host plants for oviposition inside the laying buckets under ambient laboratory conditions. Results revealed that P. desmondi teita could only complete development on T. asiatica and but not on C. anisata in both seasons. The egg incubation period on T. asiatica was significantly shorter (

P

< 0.001) compared to C. anisata during the first season (

P

= 0.595) but not in the second season. The development period of the butterfly in 1st and 2nd seasons on T. asiatica was 81.13 ± 0.44 days and 112.15 ± 1.20 days, respectively, while a female-biased sex ratio was observed in the first and second seasons. Findings from this study indicate that T. asiatica was the most suitable host plant for development of P. desmondi teita.
Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies
Authors: Hagos Yeman Brhane , Lecat Catherine S.Y. , Patel Dominic , Mikolajczak Anna , Castillo Simon P. , Lyon Emma J. , Foster Kane , Tran Thien-An , Lee Lydia S.H. , Rodriguez-Justo Manuel , Yong Kwee L. , Yuan Yinyin 
Published: November 2023

Abstract

Bone marrow trephine biopsy is crucial for the diagnosis of multiple myeloma. However, the complexity of bone marrow cellular, morphologic, and spatial architecture preserved in trephine samples hinders comprehensive evaluation. To dissect the diverse cellular communities and mosaic tissue habitats, we developed a superpixel-inspired deep learning method (MoSaicNet) that adapts to complex tissue architectures and a cell imbalance aware deep learning pipeline (AwareNet) to enable accurate detection and classification of rare cell types in multiplex immunohistochemistry images. MoSaicNet and AwareNet achieved an AUC of &gt;0.98 for tissue and cellular classification on separate test datasets. Application of MoSaicNet and AwareNet enabled investigation of bone heterogeneity and thickness as well as spatial histology analysis of bone marrow trephine samples from monoclonal gammopathies of undetermined significance (MGUS) and from paired newly diagnosed and posttreatment multiple myeloma. The most significant difference between MGUS and newly diagnosed multiple myeloma (NDMM) samples was not related to cell density but to spatial heterogeneity, with reduced spatial proximity of BLIMP1+ tumor cells to CD8+ cells in MGUS compared with NDMM samples. Following treatment of patients with multiple myeloma, there was a reduction in the density of BLIMP1+ tumor cells, effector CD8+ T cells, and regulatory T cells, indicative of an altered immune microenvironment. Finally, bone heterogeneity decreased following treatment of patients with multiple myeloma. In summary, deep learning–based spatial mapping of bone marrow trephine biopsies can provide insights into the cellular topography of the myeloma marrow microenvironment and complement aspirate-based techniques.

Significance:
Spatial analysis of bone marrow trephine biopsies using histology, deep learning, and tailored algorithms reveals the bone marrow architectural heterogeneity and evolution during myeloma progression and treatment.
BrainAGE as a measure of maturation during early
adolescence
Authors: Whitmore Lucy B. , Weston Sara J. , Mills Kathryn L. 
Published: November 2023

Abstract
The Brain-Age Gap Estimation (BrainAGE) is an important new tool that purports to evaluate brain maturity when used in adolescent populations. However, it is unclear whether BrainAGE tracks with other maturational metrics in adolescence. In the current study, we related BrainAGE to metrics of pubertal and cognitive development using both a previously validated model and a novel model trained specifically on an early adolescent population. The previously validated model was used to predict BrainAGE in two age bands, 9-11 and 10-13 years old, while the novel model was used with 9-11 year olds only. Across both models and age bands, an older BrainAGE was related to more advanced pubertal development. The relationship between BrainAGE and cognition was less clear, with conflicting relationships across the two models. Additionally, longitudinal analysis revealed moderate to high stability in BrainAGE across early adolescence. The results of the current study provide initial evidence that BrainAGE tracks with some metrics of maturation, including pubertal development. However, the conflicting results between BrainAGE and cognition lead us to question the utility of these models for non-biological processes.
In Defence of Arabic Palaeography
Authors: D’Ottone Arianna 
Published: November 2023

Abstract
Museum Cuficum Borgianum (Rome 1782) is one of Jacob Georg Christian Adler’s works which traditionally mark the birth of Arabic palaeography. Almost a century ago the Russian Arabist Ignatij Kratchovsky considered Arabic palaeography an indispensable branch of knowledge that needed to be acquired. In 2023, however, Arabic palaeography is a discipline at risk. Rarely included in Oriental studies programs, Arabic palaeography is often confused with calligraphy and is absorbed into other fields relating to the study of artefacts, whilst being a philology-based discipline with a historical vocation. This contribution seeks to stress the value of Arabic palaeography as an essential discipline in the curriculum of students and (future) researchers and its potentials to enlarge and deepen historical and art historical research.
Shrines Unyielding: Inter-Asian Networks and the Enduring Power of Sacred Spaces
Authors: Lutfi Ameem 
Published: November 2023

Abstract
This essay examines modern states’ strategic destruction and patronage of Muslim shrines to consolidate majoritarian power. Drawing on Rian Thum’s notion of shrines as “durable sacred geography,” it conceptualizes shrines as active historical agents embedded in expansive transnational networks. Their extensive sacred geography enables shrines to persist as generative fulcrums that sustain meaning by bridging heterogeneous times and spaces despite tumultuous change. Challenging prevalent views of shrines as passive symbols, the essay delineates how the flexible reassembly of tradition across far-reaching networks empowers shrines to endure as pivotal arenas of ritual contestation from the medieval era into modernity. Their astounding continuity relies on mobilizing expansive geographies to creatively reconfigure tradition across eras.
Colloquium 1 Commentary on Stróżyński
Authors: Gurtler Gary M. 
Published: November 2023

Abstract
The Comment gives corroborative support to Stróżyński’s thesis by using resources from I.6[1].7–9 and VI.5[23].1. The nature of the soul and its ascent to intellect and the One is clarified in I.6[1].7, as the soul’s ascent recaptures its own nature. It identifies not only with intellect, but directly with the One, needing only its own powers, making union with the One within one’s reach and common to all. A barrier to seeing this has been the 19th century description of mysticism as rare and incommunicable. I.6[1].8–9 add both a method of reading texts and the cosmos in ancient mystical fashion and a redefinition of light for seeing the One. In VI.5[23].1, Plotinus provides a fundamental sense of self that captures an ancient wisdom that identifies the self internally with the One not as totally other but as intimately immanent to the soul.
Colloquium 2 The Contemplative Community: Pre-Socratic Teachings and Their Appropriation in the Phaedo
Authors: Marren Marina 
Published: November 2023

Abstract
This paper elucidates how the thinking about opposition that we find in the surviving passages of Anaxagoras of Clazomenae and in the fragments of Heraclitus of Ephesus informs discussions of the separability of the body and the soul in the Phaedo. I offer a reconstruction of the way in which these pre-Socratic ideas of opposition are appropriated and refracted in Plato’s Phaedo (especially at 85e–86e, 92a–95a, 102c–e, 102b–107a). I treat Anaxagoras first, in order to explicate how his ideas make up the background of the dialogical study of the separation of the soul from the body (102b–107a). My analysis of Heraclitus comes second and shows how his ideas inform the interlocutors’ assessment of the unity characteristic of the body and the soul (92a–95a). I set the stage for the discussion of Anaxagoras and Heraclitus by relating these thinkers to the broader Pythagorean background that is apparent in the dialogue.
Colloquium 2 Commentary on Marren
Authors: Romero Ross 
Published: November 2023

Abstract
This paper responds to Marina Marren’s “The Contemplative Community: Pre-Socratic Teachings and Their Appropriation in the Phaedo” by listing areas of agreement and raising questions for further consideration. Marren’s position—that the comedic aspects of the dialogue can be understood through a retrieval of Anaxagorean mixing of opposites and Heraclitean images of doubling—is discussed. The response then challenges Marren to clarify why we should think that Plato would disagree with Socrates regarding the status of the forms and to think more deeply about divinization as a theme in the Phaedo.
Colloquium 3 Inclination and the Place of the Elements in De Caelo
Authors: Hayes Josh Michael 
Published: November 2023

Abstract
In De Caelo III 2, Aristotle observes that each element is determined by an intrinsic principle to move to its proper place: earth downward, fire upward, and water and air to their respective places in the middle. However, how are we to determine the cause of elemental motion? Aristotle admits that this ranks among the most difficult problems (μάλιστα δ’ ἀπορεῖται) as it is directly related to the argument of Physics VIII 4, which defends the view that whatever is in motion is moved by something. The question of how the elements move is not resolved until we are presented with his definition of inclination (ῥοπή) in De Caelo IV 1. Inclination is the nature of each element to move to its proper place. Aristotle concludes that the principle of inclination is a cause of motion continuously orienting the elements toward their proper places by activating that which is potentially heavy or potentially light. In what follows, I shall demonstrate the internal coherence of Aristotle’s natural philosophy by deploying inclination as a principle of motion and rest to define the nature of each element. This account of inclination as a principle of motion is consistent with Aristotle’s definition of nature in Physics II 1. As an active principle of motion, inclination is identified with the activity (ἐνέργεια) of the element enacting and maintaining its own end (ἐντελέχεια) by being at rest in its proper place. As a passive principle of motion, inclination is identified with the passivity of the element to be moved to its proper place by another element insofar as the respective element undergoes generation or substantial change.
Prismatic Jane Eyre
Authors: Reynolds Matthew , Claro Andrés , Drury Annmarie , Frank Mary , Gaudio Paola , Gould Rebecca Ruth , Habjan Jernej , Huang Yunte , Kelbert Eugenia , Kragh Ulrich Timme , Jain Abhishek , Klitgård Ida , Rychen Léa , Kütt Madli , Marques dos Santos Ana Teresa , Pazos-Alonso Cláudia , Philippou Eleni , Qasmiyeh Yousif M. , Sabiron Céline , Tahmasebian Kayvan , Pietro Vitali Giovanni 
Published: November 2023

Jane Eyre, written by Charlotte Brontë and first published in 1847, has been translated more than six hundred times into over sixty languages. Prismatic Jane Eyre argues that we should see these many re-writings, not as simple replications of the novel, but as a release of its multiple interpretative possibilities: in other words, as a prism.
Prismatic Jane Eyre develops the theoretical ramifications of this idea, and reads Brontë’s novel in the light of them: together, the English text and the many translations form one vast entity, a multilingual world-work, spanning many times and places, from Cuba in 1850 to 21st-century China; from Calcutta to Bologna, Argentina to Iran. Co-written by many scholars, Prismatic Jane Eyre traces the receptions of the novel across cultures, showing why, when and where it has been translated (and no less significantly, not translated – as in Swahili), and exploring its global publishing history with digital maps and carousels of cover images. Above all, the co-authors read the translations and the English text closely, and together, showing in detail how the novel’s feminist power, its political complexities and its romantic appeal play out differently in different contexts and in the varied styles and idioms of individual translators. Tracking key words such as ‘passion’ and ‘plain’ across many languages via interactive visualisations and comparative analysis, Prismatic Jane Eyre opens a wholly new perspective on Brontë’s novel, and provides a model for the collaborative close-reading of world literature.
Prismatic Jane Eyre is a major intervention in translation and reception studies and world and comparative literature. It will also interest scholars of English literature, and readers of the Brontës.