bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency localization of radioactive seeds lost during intracoronary brachytherapy
Authors: Krüll Andreas , Köster Ralf , Bohuslavizki Karl Heinz , Todorovic Manuel , Schmidt Rainer , Thurmann Horst , Brockhoff Carsten , Schwarz Rudolf , Münzel Thomas , Alberti Winfried 
Published: July 2004

AbstractRecently, it has been reported that brachytherapy catheters ruptured in vivo. Localization of lost β‐radiation‐emitting seeds is a problem because no appropriate technique is available that is rapid and precise. We developed a technique to localize β‐emitting seeds utilizing the effect that β‐radiation induces bremsstrahlung. The loss of a single radioactive source was simulated in an Alderson Phantom representing a human body. The β‐induced bremsstrahlung could be detected selectively by a γ‐camera. The position of the radioactive seed could be located within 5 min with an accuracy of ± 0.5 cm. The result of this study suggests that in an emergency case of loss of a brachytherapy source, a commercially available γ‐camera can be a valuable tool to detect lost β‐radiation‐emitting seeds rapidly and precisely. In addition, the technique minimizes the patient's as well as the surgeon's exposure to radiation and reduces the extent of surgical trauma. Catheter Cardiovasc Interv 2004;62:482–484. © 2004 Wiley‐Liss, Inc.
Effects of contrast media on porcine bone marrow‐derived mononuclear cells and calf myoblast viability and secretion of VEGF and MCP‐1
Authors: Baffour Richard , Pakala Rajbabu , Hellinga David , Seabron Rufus , Fournadjiev Jana , Wolfram Roswitha , Okubagzi Petros , Epstein Stephen E. , Waksman Ron 
Published: July 2004

AbstractWe investigated the effect of contrast media on bone marrow‐derived cell viability, growth factor secretion, and myoblast viability. Bone marrow was exposed to contrast media, mononuclear cells were isolated, viability was assessed by Trypan blue exclusion or cultured for 4 weeks, and conditioned medium was assayed for vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein‐1 (MCP‐1). Skeletal myoblasts viability was assessed after exposing them to contrast media. In separate experiments, bone marrow or bone marrow‐derived mononuclear cells were exposed to contrast media, cultured for 40 hr, then assessed for viability. None of the contrast media tested had any effect on bone marrow‐derived cell viability. Hypaque or Hexabrix increased myoblasts viability by 8–10%. VEGF and MCP‐1 concentrations in the conditioned medium increased in a time‐related manner. These findings support the concept that for cell therapy, bone marrow cells or myoblasts may be mixed with contrast media and injected into ischemic myocardium without compromise in viability or function. Catheter Cardiovasc Interv 2004;62:476–481. © 2004 Wiley‐Liss, Inc.
Percutaneous closure of multiple atrial septal defects with three Amplatzer septal occluder devices
Authors: Lander Stuart R. , Phillips Sabrina , Vallabhan Ravi C. , Grayburn Paul A. , Anwar Azam 
Published: July 2004

AbstractWe report on the successful closure of three atrial septal defects with three Amplatzer septal occluders in a 55‐year‐old woman. Catheter Cardiovasc Interv 2004;62:526–529. © 2004 Wiley‐Liss, Inc.
Ventricular septal rupture masquerading as coronary perforation during intervention for acute myocardial infarction
Authors: Kawamura Akio , Asakura Yasushi , Shin Hankei , Okabe Teruo , Yamane Akiko , Ogawa Satoshi 
Published: July 2004

AbstractVentricular septal rupture is a serious complication of acute myocardial infarction. We experienced a case of septal rupture immediately after primary angioplasty with thrombolysis, whose angiographic findings were similar to those of coronary perforation. The progression of septal rupture was delineated by the serial angiograms. Catheter Cardiovasc Interv 2004;62:466–470. © 2004 Wiley‐Liss, Inc.
Transcatheter patent foramen ovale closure for secondary prevention of paradoxical embolic events: Acute results from the FORECAST registry
Authors: Alameddine Fadi , Block Peter C. 
Published: July 2004

AbstractPatients with patent foramen ovale (PFO) and paradoxical embolism are at increased risk for recurrent events. Percutaneous PFO closure is a new treatment modality aimed at secondary prevention. We report the multicenter experience of interventional closure of PFO using two different devices in 272 patients. The mean age was 51 ± 14.2 years and 52.9% were males. The implantation procedure resulted in an initial complete shunt closure rate of 74.3% with a periprocedural complication rate of 6.6%. There were no deaths or pericardial tamponade. The mean procedure time was less than 44 min under either conscious sedation, local or general anesthesia. This is the largest report to date demonstrating the procedural safety, reliability, and feasibility of the transcatheter PFO closure technique with the STARFlex and CardioSEAL septal implants. Randomized clinical trials are currently in progress to identify patients most likely to benefit from this intervention. Catheter Cardiovasc Interv 2004;62:512–516. © 2004 Wiley‐Liss, Inc.
Acute and long‐term clinical and angiographic outcomes of coronary stenting using Palmaz‐Schatz stent and ACS Multi‐Link stent
Authors: Hsieh I‐Chang , Chang Hern‐Jia , Huang Hsuan‐Li , See Lai‐Chu , Chern Ming‐Shyan , Hung Kuo‐Chun , Lin Fun‐Chung , Wu Delon 
Published: July 2004

AbstractAcute and long‐term (≥ 3 years) outcomes of coronary artery stenting using Palmaz‐Schatz and Multi‐Link stent implantations between November 1995 and October 1999 were analyzed. There were 655 Palmaz‐Schatz stent implantations in 577 lesions on 477 patients (group A) and 428 Multi‐Link stent implantations in 381 lesions on 326 patients (group B). The baseline characteristics were similar in the two groups. Group B had more complex lesions, longer stenotic lesions, and larger reference vessel sizes than group A. However, both groups had a similar in‐hospital cardiac events. Four hundred and two patients with 488 lesions in group A and 260 patients with 307 lesions in group B underwent a 6‐month follow‐up coronary angiography. The restenotic rate per lesion was 16% in both groups (P = 0.872). A 3‐year angiographic follow‐up was performed in 262 patients of group A (301 lesions) and 139 patients of group B (162 lesions), and restenosis was noted in only 3 patients (1.36%) in group A and 5 patients (4%) in group B, in which the lesion was patent at the 6‐month angiographic follow‐up. Significant increase in minimal luminal diameter was noted from 2.23 ± 0.66 mm at 6 months to 2.33 ± 0.64 mm in group A (P < 0.01), and insignificant increase from 2.23 ± 0.77 to 2.28 ± 0.82 mm was noted in group B (P = 0.27). No differences were noted between the two groups in mortality, reinfarction, recurrent angina, target lesion angioplasty, or elective coronary artery bypass surgery during a follow‐up period of 60 ± 3 months. Forty‐five patients (9.4%) in group A and 18 patients (5.5%) in group B received additional stenting procedures for newly developed lesions. The overall cardiac event‐free survival was 66% in group A and 72% in group B (P = 0.844). In conclusion, the procedural success rate, in‐hospital morbidity, 6‐month angiographic results, and long‐term (≥ 3 years) clinical and angiographic outcomes were similar with coronary stenting using either Palmaz‐Schatz or Multi‐Link stent. The stented lesions were stable; however, late regression of minimal luminal diameter was noted in both groups, and progression of atherosclerotic change in the nonstented site was noted during long‐term follow‐up. Catheter Cardiovasc Interv 2004;62:453–460. © 2004 Wiley‐Liss, Inc.
Coronary anatomy and left ventricular ejection fraction in patients with type 2 diabetes admitted for elective coronary angiography
Authors: Ammann Peter , Brunner‐La Rocca Hanspeter , Fehr Thomas , Münzer Thomas , Sagmeister Markus , Angehrn Walter , Rickli Hans 
Published: July 2004

AbstractPatients with diabetes mellitus (DM) have more severe coronary artery disease and a two‐ to fourfold higher risk for myocardial infarction and death as compared to patients without DM. In this study, we analyzed coronary anatomy, left ventricular ejection fraction, and cardiac risk factors in patients with DM referred for coronary angiography and compared them with findings in nondiabetic patients. Coronary anatomy was assessed in a total of 6,234 patients and left ventricular ejection fraction in a subset of 4,767 (76.5%) patients. Diabetic patients (n = 641) were older (60.8 ± 9.6 vs. 58.5 ± 10.5 years; P < 0.0001) and had higher rates of hypertension (65% vs. 47%; P < 0.0001). Three‐vessel disease (DM 44.7% vs. no DM 25.4%; P < 0.0001) and reduced left ventricular ejection fraction (DM 58.4% ± 15.2 vs. no DM 63.9% ± 13.2; P < 0.0001) were significantly associated with DM. After adjustment for age and other vascular risk factors, the presence of DM was associated with a higher atherosclerotic burden. We conclude that advanced coronary heart disease and left ventricular dysfunction are highly prevalent in diabetic patients, independent of age and other cardiovascular risk factors. Thus, cardiac assessment in diabetic patients should, in addition to optimal diabetic control, involve screening for left ventricular dysfunction. Cathet Cardiovasc Intervent 2004;62:432–468. © 2004 Wiley‐Liss, Inc.
Novel growth stent for the permanent treatment of vessel stenosis in growing children: An experimental study
Authors: Ewert Peter , Riesenkampff Eugénie , Neuss Malte , Kretschmar Oliver , Nagdyman Nicole , Lange Peter E. 
Published: July 2004

AbstractStent implantation in stenotic vessels of infants and small children is problematic because there is no ideal stent model that is small enough to be easily introduced into the infant femoral vein or artery and, at the same time, large enough to be dilated during growth to adult vessel diameters. To overcome this problem, we designed a new stent, the growth stent. This growth stent is a balloon‐expandable metal stent. Two longitudinal halves are connected with bioabsorbable sutures so that a circular stent is created. It was postulated that after absorption of the sutures the stent would not impede growth. Twenty of these stents were implanted in the aorta, pulmonary arteries, and inferior vena cava of piglets (average weight 6.9 kg). After 18 weeks (14–23 weeks) and a mean weight gain of 59 kg, none of the stented vessels showed any significant stenosis or pressure gradient, documented by angiography and catheter pullback. During fluoroscopy, the two halves of the stent were clearly separated in all animals. The growth stent has the potential to be nonrestrictive during vessel growth, and thus is a promising new device for the permanent treatment of stenotic vessels in infancy and childhood. Catheter Cardiovasc Interv 2004;62:506–510. © 2004 Wiley‐Liss, Inc.
Luminal narrowing due to intramural hematoma shift from left anterior descending coronary artery to left circumflex artery
Authors: Hirose Makoto , Kobayashi Yoshio , Kreps Edward M. , Stone Gregg W. , Moussa Issam , Leon Martin B. , Moses Jeffrey W. 
Published: July 2004

AbstractThis case report demonstrates subacute luminal narrowing 20 days after balloon angioplasty in the left anterior descending coronary artery due to an intramural hematoma. Stenting was performed and resulted in side‐branch compromise caused by squeezing the hematoma from the left anterior descending coronary artery into the left circumflex artery. Another stent was deployed to treat the stenosis in the left circumflex artery. Catheter Cardiovasc Interv 2004;62:461–465. © 2004 Wiley‐Liss, Inc.
Correlation optimized warping and dynamic time warping as preprocessing methods for chromatographic data
Authors: Tomasi Giorgio , van den Berg Frans , Andersson Claus 
Published: July 2004

AbstractTwo different algorithms for time‐alignment as a preprocessing step in linear factor models are studied. Correlation optimized warping and dynamic time warping are both presented in the literature as methods that can eliminate shift‐related artifacts from measurements by correcting a sample vector towards a reference. In this study both the theoretical properties and the practical implications of using signal warping as preprocessing for chromatographic data are investigated. The connection between the two algorithms is also discussed. The findings are illustrated by means of a case study of principal component analysis on a real data set, including manifest retention time artifacts, of extracts from coffee samples stored under different packaging conditions for varying storage times. We concluded that for the data presented here dynamic time warping with rigid slope constraints and correlation optimized warping are superior to unconstrained dynamic time warping; both considerably simplify interpretation of the factor model results. Unconstrained dynamic time warping was found to be too flexible for this chromatographic data set, resulting in an overcompensation of the observed shifts and suggesting the unsuitability of this preprocessing method for this type of signals. Copyright © 2004 John Wiley & Sons, Ltd.
Doxorubicin for favorable histology, Stage II–III Wilms tumor
Authors: Breslow Norman E. , Ou San‐San , Beckwith J. Bruce , Haase Gerald M. , Kalapurakal John A. , Ritchey Michael L. , Shamberger Robert C. , Thomas Patrick R. M. , D'Angio Giulio J. , Green Daniel M. 
Published: July 2004

AbstractBACKGROUNDAfter randomized trials in the 1980s, doxorubicin (DOX) was added to dactinomycin plus vincristine as standard chemotherapy for patients who had Stage III Wilms tumor (WT) of favorable histology (FH). Double‐agent chemotherapy was retained for patients with Stage II disease. In this study, the authors reevaluated the efficacy of DOX using extended follow‐up and additional patients.METHODSThe relative risks (RR) (DOX vs. no DOX) of disease recurrence and mortality were estimated for patients with Stage II–III/FH WT who were enrolled in the third and fourth National Wilms Tumor Studies (NWTS‐3 and NWTS‐4). The risk of congestive heart failure (CHF) was estimated for all patients who received DOX.RESULTSNo statistically significant effects of DOX were found for patients with Stage II tumors. For patients with Stage III tumors, the 8 year recurrence‐free survival (RFS) and overall survival (OS) rates for randomized patients on NWTS‐3 were 84% and 89%, respectively, for patients who received DOX (n= 130) and 74% and 83%, respectively, for patients who did not receive DOX (n= 118). Including all patients with Stage III disease who received DOX (n= 678) and did not receive DOX (n= 138), the RRs of recurrence were 0.47 (P= 0.007) and 0.40 (P= 0.011), and local recurrence respectively, after adjustment for radiation therapy (RT) dose, whereas the RR of mortality adjusted for RT and study was 0.68 (P= 0.17). The 20‐year risk of CHF after primary DOX treatment on NWTS‐3 and NWTS‐4 was 1.2%.CONCLUSIONSThe inclusion of data from nonrandomized patients yielded estimates of DOX treatment effects for Stage III/FH WT that were stronger, albeit more susceptible to bias, than reported previously. Despite a lower reported risk of CHF, conclusive evidence that frontline therapy with DOX definitively improves survival remains elusive. Cancer 2004. © 2004 American Cancer Society.
Medullomyoblastoma: A radiographic and clinicopathologic analysis of six cases and review of the literature
Authors: Helton Kathleen J. , Fouladi Maryam , Boop Frederick A. , Perry Arie , Dalton James , Kun Larry , Fuller Christine 
Published: July 2004

AbstractBACKGROUNDMedullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components.METHODSThe authors conducted a retrospective review of the radiographic and pathologic characteristics, treatment, and clinical outcomes of six children with MMB who were treated at St. Jude Children's Research Hospital (Memphis, TN) between 1984 and 2003. Fluorescence in situ hybridization (FISH) data were available for four children. A literature review also was conducted and focused on imaging and pathologic findings.RESULTSThe median age at diagnosis was 4.5 years (range, 0.83–7.5 years). Radiographically, all tumors were cerebellar and exhibited variable enhancement, and 50% of tumors had necrotic foci. Three tumors contained discrete, magnetic resonance imaging (MRI) T2‐weighted–hypointense/computed tomography (CT)‐hyperdense enhancing regions and separate hyperintense/hypodense nonenhancing regions, which correlated microscopically with geographic islands of primitive neuroectodermal and rhabdomyoblastic cells. Large cell/anaplastic (five tumors), nodular/desmoplastic (two tumors), and classic (two tumors) medulloblastoma histologies were encountered either alone (five tumors) or in combination with each other (two tumors). All 4 tumors that were tested exhibited alterations in chromosome 17 or c‐myc amplification. All patients underwent macroscopic total resection and subsequently received chemotherapy and craniospinal (five patients) or local conformal (one patient) radiotherapy. At a median follow‐up of 92 months (range, 23–187 months), 3 patients remain alive with no evidence of disease, 2 patients have died of disease, and 1 patient has died of secondary acute lymphocytic leukemia.CONCLUSIONSThe results of the current study demonstrated the frequent correlation of biphasic nodularity (as determined by MRI or CT) with discrete rhabdomyoblastic and primitive neuroectodermal islands (as revealed by microscopy) in MMB. These results also support the view that MMB and medulloblastoma may have common tumorigenic origins, given their similar histologic and molecular features. Cancer 2004. © 2004 American Cancer Society.
High‐dose chemotherapy followed by locoregional irradiation improves the outcome of patients with international neuroblastoma staging system Stage II and III neuroblastoma with MYCN amplification
Authors: Laprie Anne , Michon Jean , Hartmann Olivier , Munzer Caroline , Leclair Marc‐David , Coze Carole , Valteau‐Couanet Dominique , Plantaz Dominique , Carrie Christian , Habrand Jean‐Louis , Bergeron Christophe , Chastagner Pascal , Défachelles Anne‐Sophie , Delattre Olivier , Combaret Valérie , Bénard Jean , Pérel Yves , Gandemer Virginie , Rubie Hervé ,   Neuroblastoma Study Group of the French Society of Pediatric Oncology
Published: July 2004

AbstractBACKGROUNDThe objective of this study was to determine whether systemic and regional, intensified treatment can improve the outcome of children who present with a localized neuroblastoma (NB) with MYCN amplification (MNA).METHODSBetween 1990 and 2000, 610 children with localized NB were included in the Localized Neuroblastoma 90 (NBL 90) and NBL 94 study from the French Society of Pediatric Oncology. Among them, 32 children had MNA with Stage II or III NB. During the first period of the study, 20 children (Group A) received postoperative conventional chemotherapy (CT) and/or radiotherapy (RT), depending on each patient's postoperative status. Subsequently, because of a high recurrence rate, the next 12 children (Group B) were given postoperative high‐dose CT (HDC) (busulfan and melphalan) with stem cell rescue (SCR) followed by RT in addition to conventional postoperative CT.RESULTSThe two groups were comparable with regard to prognostic factors (age, location of the primary lesion, International Neuroblastoma Staging System stage, lymph node invasion) and response to preoperative CT. The 6‐year overall survivalrate was significantly different between the two groups 25% ± 10% in Group A vs. 83% ± 11% in Group B; P = 0.004).CONCLUSIONSPostoperative intensification treatment with HDC, SCR, and locoregional RT resulted in higher survival rates when compared with standard treatment alone and should be considered in the treatment plan for children who are diagnosed with Stage II or III NB and MYCN amplification. Cancer 2004. © 2004 American Cancer Society.
Recurrent excitation of granule cells with basal dendrites and low interneuron density and inhibitory postsynaptic current frequency in the dentate gyrus of macaque monkeys
Authors: Austin Jenifer E. , Buckmaster Paul S. 
Published: July 2004

AbstractTemporal lobe epilepsy is often associated with pathological changes in the dentate gyrus, and such changes may be more common in humans than in some nonprimate species. To examine species‐specific characteristics that might predispose the dentate gyrus to epileptogenic damage, we evaluated recurrent excitation of granule cells with and without basal dendrites in macaque monkeys, measured miniature inhibitory postsynaptic currents (mIPSCs) of granule cells in macaque monkeys and compared them to rats, and estimated the granule cell‐to‐interneuron ratio in macaque monkeys and rats. In hippocampal slices from monkeys, whole‐cell patch recording revealed antidromically evoked excitatory PSCs that were four times larger and inhibitory PSCs that were over two times larger in granule cells with basal dendrites than without. These findings suggest that granule cells with basal dendrites receive more recurrent excitation and, to a lesser degree, more recurrent inhibition. Miniature IPSC amplitude was slightly larger in monkey granule cells with basal dendrites than in those without, but mIPSC frequency was similar and only 26% of that reported for rats. In situ hybridization for glutamic acid decarboxylase and immunocytochemistry for somatostatin, parvalbumin, and neuronal nuclei revealed interneuron proportions and distributions in monkeys that were similar to those reported for rats. However, the interneuron‐to‐granule cell ratio was lower in monkeys (1:28) than in rats (1:11). These findings suggest that in the primate dentate gyrus, recurrent excitation is enhanced and inhibition is reduced compared with rodents. These primate characteristics may contribute to the susceptibility of the human dentate gyrus to epileptogenic injuries. J. Comp. Neurol. 476:205–218, 2004. © 2004 Wiley‐Liss, Inc.