bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender-specific linkages: frailty, polypharmacy, anti-cholinergic burden, and 5-year mortality risk—a real-world analysis
Authors: Chou Yin Yi , Lee Yu Shan , Lin Chu Sheng , Chen Jun Peng , Kuo Fu-Hsuan , Lin Cheng-Fu , Chen Yi-Ming , Lin Shih-Yi 
Published: November 2023

Background
With higher age, frailty escalates the risk of falls, unexpected physical dysfunction, hospitalization, and mortality. Polypharmacy in the older population is a major challenge that not only increases medical costs, but also may worsen the risk of hospitalization and death. More importantly, the properties of anti-cholinergic drugs contribute various negative effects. This study aimed to investigate the sex difference in the association of polypharmacy, anticholinergic burden, and frailty with mortality.

Methods
Participants older than 65 years who attended the geriatric outpatient clinic of the study center between January 2015 and July 2020 were invited to participate in this retrospective study. Comprehensive geriatric assessment data were collected and the phenotype of frailty was determined by Fried’s criteria. Cox regression and the Kaplan–Meier curve were used to identify risk factors of 5-year survival along with intergroup differences in the risks.

Results
Of the 2,077 participants, 47.5% were female. The prevalence of frailty and the rate of polypharmacy were 44.7% and 60.6%, respectively. Higher age, male sex, low body mass index, low Mini-Mental State Examination scores, low activities of daily living, frailty status, polypharmacy, and a high Charlson Comorbidity Index score, and greater anticholinergic burden were significant risk factors that were associated with the 5-year all-cause mortality. Male patients with frailty exhibited the highest risks of mortality compared with male patients without frailty and female patients with or without frailty. Polypharmacy was significantly associated with a higher 5-year mortality rate in the frail male group compared with the non-frail male. In frail female group, individuals with a higher anticholinergic burden (as indicated by the Anticholinergic Cognitive Burden Scale) from drug usage exhibited an elevated 5-year mortality rate.

Conclusions
Polypharmacy and greater anticholinergic burden, synergistically interacted with frailty and intensified the 5-year mortality risk in a gender-specific manner. To mitigate mortality risks, clinicians should prudently identify polypharmacy and anticholinergic burden in the older population.
Targeting B4GALT7 suppresses the proliferation, migration and invasion of hepatocellular carcinoma through the Cdc2/CyclinB1 and miR-338-3p/MMP2 pathway
Authors: Liu Chang , Jia Yuqi , Zhao Xinan , Wang Zifeng , Zhu Xiaoxia , Zhang Chan , Li Xiaoning , Zhao Xuhua , Gong Tao , Zhao Hong , Zhang Dong , Niu Yuhu , Dong Xiushan , Li Gaopeng , Li Feng , Zhang Hongwei , Zhang Li , Xu Jun , Yu Baofeng 
Published: November 2023

Background
As a three-dimensional network involving glycosaminoglycans (GAGs), proteoglycans (PGs) and other glycoproteins, the role of extracellular matrix (ECM) in tumorigenesis is well revealed. Abnormal glycosylation in liver cancer is correlated with tumorigenesis and chemoresistance. However, the role of galactosyltransferase in HCC (hepatocellular carcinoma) is largely unknown.

Methods
Here, the oncogenic functions of B4GALT7 (beta-1,4-galactosyltransferase 7) were identified in HCC by a panel of in vitro experiments, including MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), colony formation, transwell and flow cytometry assay. The expression of B4GALT7 in HCC cell lines and tissues were examined by qPCR (real-time quantitative polymerase chain reaction) and western blot assay. The binding between B4GALT7 and miR-338-3p was examined by dual-luciferase reporter assay.

Results
B4GALT7 encodes galactosyltransferase I and it is highly expressed in HCC cells and human HCC tissues compared with para-tumor specimens. MiR-338-3p was identified to bind the 3′ UTR (untranslated region) of B4GALT7. Highly expressed miR-338-3p suppressed HCC cell invasive abilities and rescued the tumor-promoting effect of B4GALT7 in HCC. ShRNA (short hairpin RNA) mediated B4GALT7 suppression reduced HCC cell invasive abilities, and inhibited the expression of MMP-2 and Erk signaling.

Conclusion
These findings identified B4GALT7 as a potential prognostic biomarker and therapeutic target for HCC.
Integrated Application of Inorganic, Organic Sources and Biofertilizers on Nutrient Status of Soil and Aonla Leaves under Sub-Tropics of Madhya Pradesh, India
Authors: Sharma Ankur , Chawla Ritik , Dahiya Priyanka , Nagaich K. N. 
Published: November 2023

The field experiment was conducted at the Horticulture Research CRC Farm – 1 of the Department of Horticulture, School of Agriculture, ITM University Gwalior (M.P.) during the year 2019 and 2020 to study the Influence of Integrated Nutrient Management on nutrient status of soil and aonla leaves under sub-tropics of Madhya Pradesh. The experiment was laid out in the randomized block design with three replications and eleven treatments viz. (control) - RDF (1000: 500:1000 g/ tree), 3/4thof RDF + FYM, 3/4th of RDF + FYM + Azotobacter (100 g), 3/4th of RDF + FYM+ Azospirillum (100 g), 3/4th of RDF + FYM+ PSB (100 g), 3/4thof RDF + FYM+ Azotobacter + Azospirillum + PSB(100 g/tree each), ½ of RDF + FYM, 1/2 of RDF + FYM+ Azotobacter (100 g), 1/2 of RDF + FYM + Azospirillum(100 g), ½ of RDF + FYM + PSB(100 g), ½ of RDF + FYM + Azotobacter + Azospirillum + PSB (100 g/tree, each. The results revealed that among different treatments, application of ½ of RDF + FYM + Azotobacter + Azospirillum + PSB recorded higher microbial population, available nitroge, phosphorus, potassium and available soil zinc, copper and boron which was followed by application of 1/2 of RDF + FYM+ Azotobacter (100 g). Thus, application of ½ of RDF + FYM + Azotobacter + Azospirillum + PSB was found to best for improving the soil nutrient status which will in turn help in improving the yield of Aonla.
Sensor fault‐tolerant control for an internal combustion engine
Authors: Escobar‐Jiménez R. F. , Ocampo‐Rodríguez L. E. , Osorio‐Gordillo G. L. , García‐Beltrán C. D. 
Published: November 2023

SummaryThis research presents the design of a fault‐tolerant system based on a dual extended Kalman filter (DEKF) and a bank of two high‐gain observers to ensure the continuous operation of an internal combustion engine (ICE) despite total and partial faults in the mass airflow (MAF) sensor, temperature sensor, and pressure sensor. The DEKF aims to estimate the air mass flow rate () through the throttle valve. The DEKF uses the temperature and pressure measured in the intake manifold to accurately estimate the (), a failure in any of both sensors will not allow the correct functioning of the DEKF. Therefore, a bank of two high‐gain observers is proposed to estimate the pressure and temperature from only one measure. Observer 1 estimates the temperature and pressure from the pressure, and Observer 2 uses the temperature for estimating pressure and temperature. Hence, if the temperature or pressure sensors fail, the estimated temperature or pressure will replace the ill‐measure signal. The results show the effectiveness of the proposed fault‐tolerant system in the case of one sensor or multiple sensor faults.
T‐S fuzzy observer and actuator fault‐tolerant controller designs for descriptor systems
Authors: El Youssfi Naoufal , Zoulagh Taha , El Aiss Hicham , El Bachtiri Rachid , Barbosa Karina A. 
Published: November 2023

SummaryThis work focuses on designing an observer to measure states and actuator faults as well as fault‐tolerant control (FTC) for fuzzy Takagi–Sugeno (T–S) singular systems. An enhanced system is built by creating a new vector from the system state and the actuator faults. The first task is simultaneously to estimate system states and actuator faults with an adaptive observer. Then, in order to get a stabilized faulty singular system, we conceive an observer based on FTC. Using Lyapunov's approach, a linear matrix inequalities (LMIs) feasibility problem is formulated to provide the controller and the observer gains. Compared with previous studies, the proposed method significantly simplifies the design and simultaneously provides the controller and the observer gains in one step. Finally, three examples are given to demonstrate the effectiveness of the proposed control.
Directional Modification‐Functionalized Metal–Organic Framework Solid‐State Electrolytes for Highly Stable Li–O2 Batteries
Authors: Miao Cheng‐Lin , Wang Xiao‐Xue , Guan De‐Hui , Li Jia‐Xin , Wang Huan‐Feng , Xu Ji‐Jing 
Published: November 2023

AbstractMetal–organic frameworks (MOFs) with accurately directional and well‐ordered channels are considered ideal solid‐state Li‐ion conductors and are expected to be utilized in solid‐state lithium–oxygen (Li–O2) batteries to achieve rechargeable batteries with high energy density. However, the instability of MOFs toward air and lithium metal has become a crucial problem to overcome. Herein, a breakthrough is first realized in overcoming these challenges by utilizing cationic MOF (CMOF) as an advanced Li‐ion conductor. Benefiting from the positively charged sites in the CMOF, an outstanding Li+ conductivity of 6.45 × 10−4 S cm−1 at room temperature, a low activation energy of 0.15 eV, and a high transference number of 0.59 are achieved. In particular, the CMOF shows high flame retardancy, H2O, and O2− stability, which are key factors that affect the battery performance of Li–O2 batteries. Such extraordinary Li+ transport makes the assembled solid‐state Li–O2 battery cycle up to 790 h with a low overpotential of 1.09 V. The proposed novel directional modification strategy is of great significance to developing high‐performance SSEs for solid‐state Li–O2 batteries and other lithium batteries.
Hierarchical Metal‐Organic Network‐Forming Glasses toward Applications
Authors: Wei Yong‐Sheng , Ashling Christopher W. , Watcharatpong Teerat , Fan Zeyu , Horike Satoshi 
Published: November 2023

AbstractGlassy states of network‐forming coordination polymers (CPs) and metal‐organic frameworks (MOFs) represent a novel category of amorphous materials. Recent years have seen substantial progress in expanding the compound library and advancing the structural design of CP/MOF glasses. This review examines the current status and future potential of multi‐scale hierarchical CP/MOF glass materials, covering synthesis, shape adaptability, and synergistic materials. Extensive experimental and theoretical investigations of structure‐property relationships have shed light on their diverse utility, spanning areas such as permanent porosity and gas permeability, ionic and electronic conductivity, optics, catalysis, and battery technology. Additionally, the inherent properties of these glasses, coupled with their phase transformation capability, enable a range of morphological architectures. Current challenges are also addressed and offer insights into future research, with the goal of bringing CP/MOF glasses to the industry.
Exploring and Analyzing the Systemic Delivery Barriers for Nanoparticles
Authors: Wang Lin , Quine Skyler , Frickenstein Alex N. , Lee Michael , Yang Wen , Sheth Vinit M. , Bourlon Margaret D. , He Yuxin , Lyu Shanxin , Garcia‐Contreras Lucila , Zhao Yan D. , Wilhelm Stefan 
Published: November 2023

AbstractMost nanomedicines require efficient in vivo delivery to elicit meaningful diagnostic and therapeutic effects. However, en route to their intended tissues, systemically administered nanoparticles often encounter delivery barriers. To describe these barriers, the term “nanoparticle blood removal pathways” (NBRP) is proposed, which summarizes the interactions between nanoparticles and the body's various cell‐dependent and cell‐independent blood clearance mechanisms. Nanoparticle design and biological modulation strategies are reviewed to mitigate nanoparticle‐NBRP interactions. As these interactions affect nanoparticle delivery, the preclinical literature from 2011–2021 is studied, and the nanoparticle blood circulation and organ biodistribution data are analyzed. The findings reveal that nanoparticle surface chemistry affects the in vivo behavior more than other nanoparticle design parameters. Combinatory biological‐PEG surface modification improves the blood area under the curve by ≈418%, with a decrease in liver accumulation of up to 47%. A greater understanding of nanoparticle‐NBRP interactions and associated delivery trends will provide new nanoparticle design and biological modulation strategies for safer, more effective, and more efficient nanomedicines.
Diamond‐Based Supercapacitors with Ultrahigh Cyclic Stability Through Dual‐Phase MnO2‐Graphitic Transformation Induced by High‐Dose Mn‐Ion Implantation
Authors: Deshmukh Sujit , Kunuku Srinivasu , Jakobczyk Pawel , Olejnik Adrian , Chen Chien‐Hsu , Niu Huan , Yang Bing , Yang Nianjun , Bogdanowicz Robert 
Published: November 2023

AbstractWhile occasionally being able to charge and discharge more quickly than batteries, carbon‐based electrochemical supercapacitors (SCs) are nevertheless limited by their simplicity of processing, adjustable porosity, and lack of electrocatalytic active sites for a range of redox reactions. Even SCs based on the most stable form of carbon (sp3 carbon/diamond) have a poor energy density and inadequate capacitance retention during long charge/discharge cycles, limiting their practical applications. To construct a SC with improved cycling stability/energy density Mn‐ion implanted (high‐dose; 1015–1017 ions cm−2) boron doped diamond (Mn‐BDD) films have been prepared. Mn ion implantation and post‐annealing process results in an in situ graphitization (sp2 phase) and growth of MnO2 phase with roundish granular grains on the BDD film, which is favorable for ion transport. The dual advantage of both sp2
(graphitic phase) and sp3 (diamond phase) carbons with an additional pseudocapacitor (MnO2) component provides a unique and critical function in achieving high‐energy SC performance. The capacitance of Mn‐BDD electrode in a redox active aqueous electrolyte (0.05 M Fe(CN)63‐/4− + 1 M Na2SO4) is as high as 51 mF cm−2 at 10 mV s−1 with exceptional cyclic stability (≈100% capacitance even after 10 000 charge/discharge cycles) placing it among the best‐performing SCs. Furthermore, the ultrahigh capacitance retention (≈80% retention after 88 000 charge/discharge cycles) in a gel electrolyte containing a two‐electrode configuration shows a promising prospect for high‐rate electrochemical capacitive energy storage applications.
A Magnetoelastic Twist on Magnetic Noise: The Connection with Intrinsic Nonlinearities
Authors: Spetzler Elizaveta , Spetzler Benjamin , McCord Jeffrey 
Published: November 2023

AbstractIntrinsic magnetic noise limits the functionality of all magnetic field sensors and related devices using magnetic films as sensing elements. A novel origin of magnetic noise due to ferromagnetic material's magnetostriction is revealed by implementing a comprehensive multi‐level signal‐noise model and thoroughly validating it experimentally on magnetoelectric composite ΔE‐effect sensors. From electrical measurements and operando magnetic domain visualization, magnetic contributions are shown to dominate the noise floor and limit the overall performance of multi‐domain magnetoelastic sensors. The newly introduced noise contribution is correlated with the nonlinearity of the magnetostrictive properties. The effect on sensor output is particularly pronounced in magnetoelastic and magnetoelectric composite devices, but the results generally apply to all sensor devices incorporating magnetic materials. Therefore, the identified magnetic noise source makes a significant contribution to understanding the limitations of magnetic sensors and provides important guidelines for optimizing future magnetic sensors for low detectivity.
Accelerating Macroscale Superlubricity through Carbon Quantum Dots on Engineering Steel Surfaces
Authors: Du Changhe , Yang Tao , Yu Tongtong , Zhang Liqiang , Sui Xudong , Feng Yange , Wang Xiaobo , Wang Daoai 
Published: November 2023

AbstractMacroscale superlubricity on engineering steel surfaces offers a promising solution for minimizing friction and wear in engineering applications. However, achieving superlubricity typically requires a long running‐in period, which may result in significant wear for the friction pair. Herein, a new lubricant with superlubricating properties is rationally designed by using polyethylene glycol (PEG) and critic acid (CA) under complexing effect with a running‐in period of about 800 s. Importantly, the introduction of carbon quantum dots (CQDs) obtained from the pyrolysis of CA into PEG aqueous solution shortens the running‐in period for achieving macroscale superlubricity (µ ≈ 0.005) between steel/steel contact to 44 s. The corresponding wear rate (1.15 × 10−7 mm3 N−1 m−1) on the steel disk is reduced by 77% due to the shorter running‐in time. Furthermore, the surface analysis combined with the molecular dynamics simulations demonstrates that CQDs easily adsorb on the surface of the friction pair, forming a carbon film that reduces interaction energy between the lubricant molecules and the substrate. This work provides new insights into the lubrication mechanism of CQDs and contributes to the design of liquid superlubricants with short running‐in periods and low wear rates on engineering steel surfaces.
Chaotropic Salt‐Aided “Water‐In‐Organic” Electrolyte for Highly Reversible Zinc‐Ion Batteries Across a Wide Temperature Range
Authors: Wang Ziqing , Diao Jiefeng , Burrow James N. , Brotherton Zachary W. , Lynd Nathaniel A. , Henkelman Graeme , Mullins Charles Buddie 
Published: November 2023

AbstractAqueous zinc‐ion batteries are promising alternatives to lithium‐ion batteries due to their cost‐effectiveness and improved safety. However, several challenges, including corrosion, dendrites, and water decomposition at the Zn anode, hinder their performance. Herein, an approach is proposed, that deviates from the conventional design by adding water into a propylene carbonate‐based organic electrolyte to prepare a non‐flammable “water‐in‐organic” electrolyte. The chaotropic salt Zn(ClO4)2 exploits the Hofmeister effect to promote the miscibility of immiscible liquid phases. Interactions between propylene carbonate and water restrict water activity and mitigate unfavorable reactions. This electrolyte facilitates preferential Zn (002) deposition and the formation of solid electrolyte interphase. Consequently, the “water‐in‐organic” electrolyte achieves a 99.5% Coulombic efficiency at 1 mA cm−2 over 1000 cycles in Zn/Cu cells, and constant cycling over 1000 h in Zn/Zn symmetric cells. A Na0.33V2O5/Zn battery exhibits impressive cycling stability with a capacity of 175 mAh g−1 for 800 cycles at 2 A g−1. Additionally, this electrolyte enables sustainable cycling across a wide temperature range from −20 to 50 °C. The design of a “water‐in‐organic” electrolyte employing a chaotropic salt presents a potential strategy for high‐performance electrolytes in zinc‐ion batteries with a large stability window and a wide temperature range.
Great Enhancement in the Seebeck Coefficient of PEDOT:PSS by Polaron Level Splitting via π–π Overlapping with Nonpolar Small Aromatic Molecules
Authors: Li Chang'an , Shan Chengwei , Luo Dou , Gu Xiaoyu , Le Qiujian , Kyaw Aung Ko Ko , Dong Zhen , Sun Kuan , Ouyang Jianyong 
Published: November 2023

AbstractOrganic thermoelectric (TE) materials are regarded as the next‐generation TE materials because of their merits including low cost, high mechanical flexibility, and low intrinsic thermal conductivity. However, their Seebeck coefficient is usually quite low. Herein, a new strategy is demonstrated to greatly enhance the Seebeck coefficient of poly(3,4‐ethylenedioxy‐thiophene):poly(styrenesulfonate) (PEDOT:PSS), which is the most popular TE polymer, through polaron level splitting via π–π overlapping with nonpolar small aromatic molecules including anthracene, naphthalene, and pyrene. Although these aromatic molecules are neither oxidizing nor reducing agent, they can greatly enhance the Seebeck coefficient of PEDOT:PSS films pre‐treated with dimethyl sulfoxide, acid, or acid then base, while they do not lower the electrical conductivity too much. Through such a treatment with anthracene, the Seebeck coefficient can be up to 45.5 µV K−1, and the ZT value can be up to 0.27. The enhancement is ascribed to the splitting of the lower polaron energy level of PEDOT, which is induced by the π–π overlapping between the aromatic compounds and conjugated PEDOT. This can shift up the Fermi level, thereby enhancing the Seebeck coefficient.
Sampling the Materials Space for Conventional Superconducting Compounds
Authors: Cerqueira Tiago F. T. , Sanna Antonio , Marques Miguel A. L. 
Published: November 2023

AbstractA large scale study of conventional superconducting materials using a machine‐learning accelerated high‐throughput workflow is performed, starting by creating a comprehensive dataset of around 7000 electron–phonon calculations performed with reasonable convergence parameters. This dataset is then used to train a robust machine learning model capable of predicting the electron–phonon and superconducting properties based on structural, compositional, and electronic ground‐state properties. Using this machine, the transition temperatures (Tc) of approximately 200 000 metallic compounds are evaluated, all of which are on the convex hull of thermodynamic stability (or close to it) to maximize the probability of synthesizability. Compounds predicted to have Tc values exceeding 5 K are further validated using density‐functional perturbation theory. As a result, 541 compounds with Tc values surpassing 10 K, encompassing a variety of crystal structures and chemical compositions, are identified. This work is complemented with a detailed examination of several interesting materials, including nitrides, hydrides, and intermetallic compounds. Particularly noteworthy is LiMoN2, which is predicted to be superconducting in the stoichiometric trigonal phase, with a Tc exceeding 38 K. LiMoN2 has previously been synthesized in this phase, further heightening its potential for practical applications.
Engineering Kirigami Frameworks Toward Real‐World Applications
Authors: Jin Lishuai , Yang Shu 
Published: November 2023

AbstractThe surge in advanced manufacturing techniques has led to a paradigm shift in the realm of material design from developing completely new chemistry to tailoring geometry within existing materials. Kirigami, evolved from a traditional cultural and artistic craft of cutting and folding, has emerged as a powerful framework that endows simple 2D sheets with unique mechanical, thermal, optical, and acoustic properties, as well as shape‐shifting capabilities. Given its flexibility, versatility, and ease of fabrication, there are significant efforts in developing kirigami algorithms to create various architectured materials for a wide range of applications. This review summarizes the fundamental mechanisms that govern the transformation of kirigami structures and elucidates how these mechanisms contribute to their distinctive properties, including high stretchability and adaptability, tunable surface topography, programmable shape morphing, and characteristics of bistability and multistability. It then highlights several promising applications enabled by the unique kirigami designs and concludes with an outlook on the future challenges and perspectives of kirigami‐inspired metamaterials toward real‐world applications.