bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying optimal candidates for autologous peripheral blood stem cell therapy in patients with decompensated liver cirrhosis: a prognostic scoring system
Authors: Tian Siyuan , Guo Guanya , Zhou Xia , Liu Yansheng , Jia Gui , Zheng Linhua , Cui Lina , Wang Kemei , Zhang Miao , Sun Keshuai , Ma Shuoyi , Yang Chunmei , Zhou Xinmin , Guo Changcun , Shang Yulong , Han Ying 
Published: January 2024

Abstract
Background
Stem cell transplantation shows great potential to improve the long-term survival of cirrhosis patients. However, therapeutic effects may not be homogeneous across the whole study population. This study constructed an easy-to-use nomogram to improve prognostic prediction and aid in treatment decision making for cirrhotic patients.

Methods
From August 2005 to April 2019, 315 patients with decompensated cirrhosis receiving autologous peripheral blood stem cell (PBSC) transplantation were enrolled in this study. They were randomly classified into training (2/3) and validation (1/3) groups. A predictive model was developed using Cox proportional hazard models and subsequently validated. The predictive performance of the model was evaluated and also compared with other prognostic models.

Results
Age, creatinine, neutrophil-to-lymphocyte ratio, and Child–Turcotte–Pugh class were included in the nomogram as prognostic variables. The nomogram showed high discrimination power concerning the area under receiver operating characteristic curves (3/5-year AUC: 0.742/0.698) and good consistency suggested by calibration plots. Patients could be accurately stratified into poor- and good-outcome groups regarding liver-transplantation free survival after receiving PBSC therapy (P < 0.001). Compared with poor-outcome group, the liver function of patients listed for liver transplantation in the good-outcome group was significantly improved (P < 0.001). Besides, our nomogram achieved a higher C-index (0.685, 95% CI 0.633–0.738) and better clinical utility compared with other conventional prognostic models.

Conclusions
The proposed nomogram facilitated an accurate prognostic prediction for patients with decompensated cirrhosis receiving PBSC transplantation. Moreover, it also held the promise to stratify patients in clinical trials or practice to implement optimal treatment regimens for individuals.
Genetic algorithm-based secure cooperative control for high-order nonlinear multi-agent systems with unknown dynamics
Authors: Wang Xin , Yang Dongsheng , Dolly D Raveena Judie , Chen Shuang , Alassafi Madini O. , Alsaadi Fawaz E. , Lyu Jianhui 
Published: January 2024

AbstractResearch has recently grown on multi-agent systems (MAS) and their coordination and secure cooperative control, for example in the field of edge-cloud computing. MAS offers robustness and flexibility compared to centralized systems by distributing control across decentralized agents, allowing the system to adapt and scale without overhaul. The collective behavior emerging from agent interactions can solve complex tasks beyond individual capabilities. However, controlling high-order nonlinear MAS with unknown dynamics raises challenges. This paper proposes an enhanced genetic algorithm strategy to enhance secure cooperative control performance. An efficient encoding method, adaptive decoding schemes, and heuristic initialization are introduced. These innovations enable compelling exploration of the solution space and accelerate convergence. Individual enhancement via load balancing, communication avoidance, and iterative refinement intensifies local search. Simulations demonstrate superior performance over conventional algorithms for complex control problems with uncertainty. The proposed method promises robust, efficient, and consistent solutions by adapting to find optimal points and exploiting promising areas in the space. This has implications for securely controlling real-world MAS across domains like robotics, power systems, and autonomous vehicles.
Transcriptomic analysis identifies diagnostic genes in polycystic ovary syndrome and periodontitis
Authors: Liu Xiaodan , Zhang Jingran , Wang Xiao , Zhang Zhihui 
Published: January 2024

Abstract
Purpose
To investigate underlying co-mechanisms of PCOS and periodontitis through transcriptomic approach.

Methods
PCOS and periodontitis gene expression data were downloaded from the GEO database to identify differentially expressed genes. GO and KEGG pathway enrichment analysis and random forest algorithm were used to screen hub genes. GSEA analyzed the functions of hub genes. Correlations between hub genes and immune infiltration in two diseases were examined, constructing a TF-ceRNA regulatory network. Clinical samples were gathered from PCOS and periodontitis patients and RT-qPCR was performed to verify the connection.

Results
There were 1661 DEGs in PCOS and 701 DEGs in periodontitis. 66 intersected genes were involved and were enriched in immune and inflammation-related biological pathways. 40 common genes were selected from the PPI network. RF algorithm demonstrated that ACSL5, NLRP12, CCRL2, and CEACAM3 were hub genes, and GSEA results revealed their close relationship with antigen processing and presentation, and chemokine signaling pathway. RT-qPCR results confirmed the upregulated gene expression in both PCOS and periodontitis.

Conclusion
The 4 hub genes ACSL5, NLRP12, CCRL2, and CEACAM3 may be diagnostic genes for PCOS and periodontitis. The created ceRNA network could provide a molecular basis for future studies on the association between PCOS and periodontitis.
COVID-19-related cardiovascular disease risk due to weight gain: a nationwide cohort study
Authors: Lee Su Kyoung , Lim Yohwan , Jeong Seogsong , Han Hyun Wook 
Published: January 2024

Abstract
Background
Cardiovascular disease (CVD) is a significant contributor to morbidity and mortality worldwide, with CVD and post-acute COVID-19 associated CVD increasing. It remains unknown whether COVID-19 patients with weight gain are at a high risk for CVD events. Therefore, the primary objective of this study is to investigate the association between weight control and the risk of CVD following COVID-19.

Methods
The study included 2,024,728 adults who participated in two rounds of health screening between 2017 and 2020. The final cohort, which included 70,996 participants in the COVID-19 group and 212,869 participants in the control group. The adjusted hazard ratio of BMI change to CVD risk was calculated using Cox proportional hazards regression.

Results
We identified a total of 2869 cases of CVD (861 events for COVID-19 group and 2,008 events for the control group). Compared to individuals with a stable BMI, COVID-19 patients without obesity had an increased risk of CVD (adjusted hazard ratio [aHR] = 2.28; 95% confidence interval [CI], 1.15–4.53; p-value = 0.018). Additionally, non-COVID-19 patients with obesity also exhibited a higher risk of CVD (aHR = 1.58; 95% CI, 1.01–2.47; p-value = 0.046).

Conclusion
In conclusion, people who gained weight during the pandemic, regardless of their weight category, had a significantly higher risk of CVD associated with COVID-19 compared to those who maintained their weight before the pandemic.
Facile fabrication and characterization of MXene/cellulose composites for electrical properties, electric heating performance
Authors: Kang Chan Sol , Kim Jong Kyu , Lee Chae-Seok , Chang HoJong , Cho Yeong Heon , Prasad Cheera , Choi Hyeong Yeol 
Published: January 2024

AbstractDeveloping energy-efficient and multifunctional wearable electronic textiles (E-textiles) is a significant challenge. This study investigates MXene-coated cellulose hybrid fibers, focusing on their electrical properties, heating performance, and thermal stability. The fabrication process involves continuous dipping of cellulose fibers into an aqueous MXene solution, resulting in the creation of MXene-coated cellulose hybrid fibers. We confirm the uniform coating of MXene sheets on the cellulose fiber surfaces, with increasing content throughout the dip coating cycle, as evidenced by X-ray diffraction and scanning electron microscopy analysis. The high thermal conductivity of MXene acts as a heat source, impacting the thermal stability of cellulose fibers at lower temperatures. Additionally, the electrical properties of MXene/cellulose hybrid fiber composites are influenced at elevated temperatures. Remarkably, the longitudinal electrical conductivity of the MXene-coated cellulose fiber composites exhibits a notable increase of 0.06 S/cm after the final coating cycle, demonstrating the effective and conductive nature of the layer-by-layer MXene network formed on the cellulose fibers.
Intestinal Behçet's and suspected intestinal Behçet’s disease: a report of four surgical cases
Authors: Ono Rika , Tominaga Tetsuro , Nonaka Takashi , Takamura Yuma , Oishi Kaido , Shiraishi Toshio , Hashimoto Shintaro , Noda Keisuke , Sawai Terumitsu , Okano Shinji , Nagayasu Takeshi 
Published: January 2024

Abstract
Background
Intestinal Behçet's disease (BD) is often associated with ulceration that requires surgery, including perforation and abscess formation. However, no consensus has been reached on the optimal extent of resection or treatment strategy. This study reviewed four cases of intestinal or suspected intestinal BD.

Case presentations
In Case 1, a 74-year-old woman diagnosed with BD 2 years earlier was treated with anti-tumor necrosis factor α antibody (Infliximab) and steroids. She had oral and pubic ulcers. After close investigation of abdominal pain, perforation of the gastrointestinal tract was suspected and surgery was performed. Multiple perforating ulcers and abscesses were found in the distal ileum, and the small intestine was resected. Postoperatively, the patient was treated with an increased steroid dose and symptoms have remained stable. Case 2 involved a 69-year-old woman with oral and pubic ulcers, ocular ulcer, and skin lesions. She experienced sudden onset of abdominal pain during treatment for lymphoma. She showed multiple perforating ulcers throughout the ileum and underwent resection of the small intestine and ileostomy. Upper abdominal pain appeared during postoperative treatment for high-output syndrome. The patient underwent omentoplasty after perforation of the upper gastrointestinal tract was diagnosed. Postoperatively, anti-interleukin-1 beta antibodies (canakinumab) was administered to control the disease. Case 3 involved an 81-year-old, previously healthy woman. She presented to her previous physician with complaints of pubic ulcer, hemorrhage and abdominal pain. Colonoscopy showed multiple ulcers throughout the entire colon. Steroid therapy was started, but bleeding proved difficult to control and total proctocolectomy was performed. Histopathology revealed multiple perforating ulcers and BD was diagnosed. Postoperatively, the patient remains under steroid control. Case 4 involved a 43-year-old man with abdominal pain who showed abscess formation in the ileocecal region. After excision of the ileocecal area, multiple ulcers were diagnosed. Two years later, abdominal pain recurred and free air was found in the abdomen on close imaging. Emergency anastomotic resection was performed due to ulceration and perforation of the anastomosis.

Conclusions
Intestinal BD may flare up after surgical treatment and require multiple surgeries. Introducing pharmacotherapy as soon as possible after surgical treatment is important to control the disease.
Retinal neurovascular alteration in type 2 diabetes with renal impairment in association with systemic arterial stiffness
Authors: Ari Widjaja Sauli , Mieler William F. , Sasono Wimbo , Soelistijo Soebagijo A. , Kartasasmita Arief S. , Murakami Akira , Nakao Shintaro 
Published: January 2024

Abstract
Background
Diabetic retinopathy (DR) patients should be alert for subclinical macroangiopathy. We aimed to investigate the association between retinal neurovascular alteration and systemic arterial stiffness in type 2 diabetes mellitus (type 2 DM) patients with varying degrees of renal impairment.

Methods
The study included 170 patients with confirmed diagnosis of type 2 DM aged ≥18 years old. Renal function was assessed by estimated glomerular filtration rate (eGFR). Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI). Retinal neurovascular parameters were derived from Optical Coherence Tomography (OCT)/OCT-Angiography, represented by vessel density (VD Central, Inner, Outer, Full), foveal avascular zone (FAZ area and FAZ perimeter) of the superficial capillary plexus, the average of macular ganglion cell-inner plexiform layer thickness (ave mGC-IPLt) and the average of retinal nerve fiber layer thickness (aveRNFLt). The association between variables among the groups (according to renal function, diabetic retinopathy (DR) severity, and arterial stiffness categories) were analyzed by regression analysis with multiple hypothesis testing commands.

Results
Out of the 265 eyes, the mean DM duration and HbA1c were 6.21 ± 6.37 years and 8.44 ± 2.06% respectively. While the mean of eGFR, baPWV and ABI were 66.78 ± 32.80 ml/min/1.73m2, 15.49 ± 3.07 m/s, and 1.05 ± 0.12, respectively. Patients with more severe renal impairment demonstrated longer DM duration (p < 0.001), higher baPWV (p < 0.0001), and retinal vascular alteration. Proliverative DR group showed the lowest eGFR (p < 0.0001), highest baPWV (p < 0.0001), and retinal neurovascular changes. Significantly lower eGFR and retinal vascular alteration were found in the baPWV > 14 group. Some neurovascular parameters were significantly negatively correlated with baPWV; moreover, retinal neurovascular changes were also noted in the abnormal ABI group.

Conclusions
The strong association between changes in the retinal neurovascular system, DR severity, renal impairment, and arterial stiffness in type 2 DM was confirmed. Patients with more severe renal impairment had higher levels of arterial stiffness, more severe DR and retinal neurovascular alteration. Retinal neurovascular changes seen in OCT/OCTA might mimic renal microvascular alteration and systemic arterial stiffness. Therefore, assessment of baPWV and OCT/OCTA should be integrated in DR screening to enhance cardiovascular risk stratification and prognosis as well as to provide clinically useful early identification of subclinical micro- and macrovascular alterations.
Fully endoscopic far-lateral supracerebellar infratentorial approach for trigeminal neuralgia: illustrative case reports
Authors: Yao Hong , Yang Wenlei , Tang Hao , Cheng Yijun , Lin Shaojian , Wu Zhe Bao 
Published: January 2024

Abstract
Background
Trigeminal neuralgia (TN) is a common cause of craniofacial pain. The retrosigmoid approach is usually used to treat TN, but no cases of endoscopic far-lateral supracerebellar infratentorial approach (EF-SCITA) were used to undergo operation for TN.

Case presentation
Two patients were presented with severe facial pain and preliminary diagnosis was TN. Preoperative magnetic resonance imaging revealed that a superior cerebellar artery (SCA) compressed the trigeminal nerve in case 1, and a tumor located in the petrous apex extending into the Meckel’s cave compressed the trigeminal nerve in case 2. Operations were achieved through the EF-SCITA. The pain was totally relieved with no postsurgical complications in both cases.

Conclusions
We present the first two case reports of EF-SCITA to relieve classical and secondary TN successfully. The EF-SCITA can be a promising approach for treating TN.
4400 TEU cargo ship dynamic analysis by Gaidai reliability method
Authors: Gaidai Oleg , Wang Fang , Cao Yu , Liu Zirui 
Published: January 2024

AbstractModern cargo vessel transport constitutes an important part of global economy; hence it is of paramount importance to develop novel, more efficient reliability methods for cargo ships, especially if onboard recorded data is available. Classic reliability methods, dealing with timeseries, do not have the advantage of dealing efficiently with system high dimensionality and cross-correlation between different dimensions. This study validates novel structural reliability method suitable for multi-dimensional structural systems versus a well-established bivariate statistical method. An example of this reliability study was a chosen container ship subjected to large deck panel stresses during sailing. Risk of losing containers, due to extreme motions is the primary concern for ship cargo transport. Due to non-stationarity and complicated nonlinearities of both waves and ship motions, it is challenging to model such a phenomenon. In the case of extreme motions, the role of nonlinearities dramatically increases, activating effects of second and higher order. Moreover, laboratory tests may also be questioned. Therefore, data measured on actual ships during their voyages in harsh weather provides a unique insight into statistics of ship motions. This study aimed at benchmarking and validation of the state-of-the-art method, which enables extraction of the necessary information about the extreme system dynamics from onboard measured time histories. The method proposed in this study opens up broad possibilities of predicting simply, yet efficiently potential failure or structural damage risks for the nonlinear multi-dimensional cargo vessel dynamic systems as a whole. Note that advocated novel reliability method can be used for a wide range of complex engineering systems, thus not limited to cargo ship only.
Simulated cardiopulmonary bypass: a high fidelity model for developing and accessing clinical perfusion skills
Authors: Searles Bruce E. , Riley Jeffrey B. , Darling Edward M. , Wiles Jason R. 
Published: January 2024

Abstract
Background
Traditionally, novice perfusionists learn and practice clinical skills, during live surgical procedures. The profession’s accrediting body is directing schools to implement simulated cardiopulmonary bypass (CPB) into the curriculum. Unfortunately, no CPB simulation models have been validated. Here we describe the design and application of a CPB simulation model.

Methods
A CPB patient simulator was integrated into a representative operative theater and interfaced with a simple manikin, a heart-lung machine (HLM), clinical perfusion circuitry, and equipment. Participants completed a simulation scenario designed to represent a typical CPB procedure before completing an exit survey to assess the fidelity and validity of the experience. Questions were scored using a 5-point Likert scale.

Results
Participants (n = 81) contributed 953 opinions on 40 questions. The participants reported that the model of simulated CPB (1) realistically presented both the physiologic and technical parameters seen during CPB (n = 347, mean 4.37, SD 0.86), (2) accurately represented the psychological constructs and cognitive mechanisms of the clinical CPB (n = 139, mean 4.24, SD 1.08), (3) requires real clinical skills and reproduces realistic surgical case progression (n = 167, mean 4.38, SD 0.86), and (4) would be effective for teaching, practicing, and assessing the fundamental skills of CPB (n = 300, mean 4.54, SD 0.9). Participants agreed that their performance in the simulation scenario accurately predicted their performance in a real clinical setting (n = 43, mean 4.07, SD 1.03)

Conclusion
This novel simulation model of CPB reproduces the salient aspects of clinical CPB and may be useful for teaching, practicing, and assessing fundamental skills.
Preclinical evaluation of an 18F-labeled Nε-acryloyllysine piperazide for covalent targeting of transglutaminase 2
Authors: Wodtke Robert , Laube Markus , Hauser Sandra , Meister Sebastian , Ludwig Friedrich-Alexander , Fischer Steffen , Kopka Klaus , Pietzsch Jens , Löser Reik 
Published: January 2024

Abstract
Background
Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains importance in malignant cells. Thus, there is a great need of theranostic probes for targeting tumor-associated TGase 2, and targeted covalent inhibitors appear to be particularly attractive as vector molecules. Such an inhibitor, equipped with a radionuclide suitable for noninvasive imaging, would be supportive for answering the general question on the possibility for functional characterization of tumor-associated TGase 2. For this purpose, the recently developed 18F-labeled Nε-acryloyllysine piperazide [18F]7b, which is a potent and selective irreversible inhibitor of TGase 2, was subject to a detailed radiopharmacological characterization herein.

Results
An alternative radiosynthesis of [18F]7b is presented, which demands less than 300 µg of the respective trimethylammonio precursor per synthesis and provides [18F]7b in good radiochemical yields (17 ± 7%) and high (radio)chemical purities (≥ 99%). Ex vivo biodistribution studies in healthy mice at 5 and 60 min p.i. revealed no permanent enrichment of 18F-activity in tissues with the exception of the bone tissue. In vivo pretreatment with ketoconazole and in vitro murine liver microsome studies complemented by mass spectrometric analysis demonstrated that bone uptake originates from metabolically released [18F]fluoride. Further metabolic transformations of [18F]7b include mono-hydroxylation and glucuronidation. Based on blood sampling data and liver microsome experiments, pharmacokinetic parameters such as plasma and intrinsic clearance were derived, which substantiated the apparently rapid distribution of [18F]7b in and elimination from the organisms. A TGase 2-mediated uptake of [18F]7b in different tumor cell lines could not be proven. Moreover, evaluation of [18F]7b in melanoma tumor xenograft models based on A375-hS100A4 (TGase 2 +) and MeWo (TGase 2 −) cells by ex vivo biodistribution and PET imaging studies were not indicative for a specific targeting.

Conclusion
[18F]7b is a valuable radiometric tool to study TGase 2 in vitro under various conditions. However, its suitability for targeting tumor-associated TGase 2 is strongly limited due its unfavorable pharmacokinetic properties as demonstrated in rodents. Consequently, from a radiochemical perspective [18F]7b requires appropriate structural modifications to overcome these limitations.
Plasma galectin-9 levels correlate with blood monocyte turnover and predict simian/human immunodeficiency virus disease progression
Authors: Zablocki-Thomas Laurent , Ardeshir Amir , Takahashi Naofumi , White Kevin S. , Sumer Cinar Efe , Wallis Zoey K. , Didier Elizabeth S. , Kim Woong-Ki , Williams Kenneth C. , Kuroda Marcelo J. 
Published: January 2024

Abstract
Background
Late-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that profound changes in the monocyte turnover (MTO) rate in rhesus macaques infected by the simian immunodeficiency virus (SIV) outperforms declining CD4 + T-cell counts in predicting rapid health decline associated with progression to terminal disease. High MTO is associated with increased tissue macrophage death. However, MTO analysis is complex and not directly applicable to humans.

Methods
We explored blood-available biomarkers associated with MTO using comprehensive immune cell profiling via flow cytometry, blood cell count and chemistry, and ELISA.

Results
Plasma galectin-9 was identified as the most highly correlated marker with MTO. This correlation remained statistically significant during acute, chronic, and late-stage infections caused by three different SIV strains tested. In addition, the galectin-9 level also predicted decline in animal health, requiring medical cull. The correlation between MTO and galectin-9 was maintained even in uninfected animals showing variable MTO.

Conclusions
These findings support the exploration of galectin-9 as a surrogate biomarker of MTO for non-invasive monitoring of disease progression (e.g. HIV) that may also be applicable in humans and as a potential indicator of tissue macrophages apoptosis.