bluuebunny/crossref_metadata_2025_split huggingface dataset:
РАДЯНСЬКА УКРАЇНІЗАЦІЯ: ВІД МАНІПУЛЯЦІЇ ДО РЕПРЕСІЙ
Authors: Коляструк Ольга 
Published: December 2023

У статті показано, як більшовицька українізація сприяла закріпленню радянської влади в українській республіці, забезпечила формування української культури «національної за формою і соціалістичної за змістом», заміні національної ідентичності радянською. За допомогою цієї політики більшовики домоглися легітимізації своєї окупаційної влади в УСРР, досягли радянізації українського суспільства, його упокорення шляхом позірної національно-культурної програми з використанням силових практик репресій проти свідомих носіїв української ідентичності. Українізація була колонізаторською за своєю метою, методами впровадження і результатами дії, мала репресивний характер, її наслідки відчутні і на сьогоднішньому етапі.
Ключові слова: «українізація», більшовицька маніпуляція, українська мова, національна політика, репресії, національна еліта.
Cross­Media Platform as a Tool for Promoting the Cultural Heritage of the Ukrainian Diaspora in the Conditions of Development of a Digital Society
Authors: Bilushchak T. , Primakova D. 
Published: December 2023

The relevance of the research topic is determined by the socio-cultural processes in modern Ukraine. Therefore, the study and popularization of the cultural heritage of the Ukrainian diaspora among the youth with the help of information and communication technologies during the development of a digital society becomes especially relevant.
The purpose of the work is to use a cross-media platform as an application in information and communication technologies to popularize the cultural heritage of the Ukrainian diaspora under the conditions of a digital society formation.
The research methodology is based on the application of general scientific and special research methods. In particular, the method of historical and source research, analysis of scientific literature, methods of analysis and synthesis, content analysis, comparative and analytical monitoring of Internet resources, as well as the “Tree of Goals” method were used.
The results. As a result of scientific research, a cross-media platform project was implemented as a means of popularizing the cultural heritage of the Ukrainian diaspora using a virtual exhibition in the form of a website, a Telegram channel, and an Instagram page. The main stages of the product creation were described, the approbation of the project was carried out and its possibilities as a tool for spreading knowledge about the cultural heritage of the Ukrainian diaspora were determined.
The scientific novelty of the obtained results lies in the fact that the process of representation and popularization of the cultural heritage of the Ukrainian diaspora using a cross-media platform as a means of educational activity under the conditions of a digital society formation, was for the first time clarified.
The practical significance. The practical significance of the results of the work is that the conducted research will allow teachers to increase student/pupil interest in the cultural heritage of the Ukrainian diaspora in thematic courses, allow implementation of projects using a cross-media platform, and provide students/pupils an additional platform for studying this material or representing their creative projects.
Conclusions. It is established that a cross-media platform is a method of communication that involves a dialogue with the audience through the use of multimedia and various platforms for communication.
Uterine Myxoid Leiomyosarcoma with Stromal Chondroid Metaplasia: A Rare Case Report
Authors: Akbarzadeh-Jahromi Mojgan , Sari Aslani Fatemeh , Taheri Negar , Najib Fatemehsadat 
Published: December 2023

Background: Uterine leiomyosarcoma is a rare gynecological disease. Myxoid leiomyosarcoma (mLMS) is an aggressive and very uncommon type of leiomyosarcoma, with few cases reported in English literature. Stromal metaplasia is rare in leiomyosarcoma. Here we present huge uterine myxoid leiomyosarcoma with stromal chondroid metaplasia. Case Report: A 48â€“yearâ€“old single woman with lower abdominal pain and increased abdominal circumference. The detected mass on imaging was diagnosed as uterine mLMS with stromal chondroid metaplasia in the histopathological examination after surgery. Conclusion: Myxoid leiomyosarcoma should be considered in uterine mass with extensive myxoid change, infiltrative border, low mitotic count, and mild atypia. Stromal chondroid metaplasia can be seen in the myxoid leiomyosarcoma. [GMJ.2021;10:e1817]
Plasma Cytokines Profile in Subjects with Alzheimerâ€™s Disease: Interleukin 1 Alpha as a Candidate for Target Therapy
Authors: Karima Saeed , Mahdavi Meisam , Rajaei Shima , Safarpour Lima Behnam , Ataeia Reza , Sepasi Tehrani Hessam , Mahmoodi Baram Somayeh , Tafakhori Abbas , Shateri Somayeh , Fatemi Hamid , Mokhtari Farzad , Yarhosseini Amir , Gorji Ali , Aghamolaii Vajihe , Nikzameer Abdolrahim , Ghahremani Hossein 
Published: December 2023

Background: Alzheimerâ€™s disease (AD) is the main cause of the neurodegenerative disorder, which is not detected unless the cognitive deficits are manifested. An early prediagnostic specific biomarker preferably detectable in plasma and hence non-invasive is highly sought-after. Various hypotheses refer to AD, with amyloid-beta (AÎ²) being the most studied hypothesis and inflammation being the most recent theory wherein pro-and anti-inflammatory cytokines are the main culprits. Materials and Methods: In this study, the cognitive performance of AD patients (n=39) was assessed using mini-mental state examination (MMSE), AD assessment scale-cognitive subscale (ADAS-cog), and clinical dementia rating (CDR). Their neuropsychiatric symptoms were evaluated through neuropsychiatric inventoryâ€“questionnaire (NPI-Q). Moreover, plasma levels of routine biochemical markers, pro-/anti-inflammatory cytokines such as tumor necrosis factor Î± (TNF-Î±), interleukin-1 Î± (IL-1Î±), IL-1Î², IL-2, IL-4, IL-6, IL-8, IL-12p70, IL-10, Interferon-gamma, chemokines, including prostaglandin E2 (PGE-2), monocyte chemoattractant protein-1, interferon gamma-induced protein 10, AÎ² peptide species (42, 40) and Transthyretin (TTR) were measured. Results: Our results revealed that AÎ² 42/40 ratio and TTR were correlated (r=0.367, P=0.037). IL-1Î± was directly correlated with ADAS-cog (r=0.386, P=0.017) and AÎ² 40 (r=0.379, P=0.019), but was inversely correlated with IL-4 (r=-0.406, P=0.011). Negative correlations were found between MMSE and PGE2 (r=-0.405, P=0.012) and TNF-Î±/ IL-10 ratio (r=-0.35, P=0.037). CDR was positively correlated with both PGE2 (r=0.358, P=0.027) and TNF-Î± (r=0.416, P=0.013). There was a positive correlation between NPI-caregiver distress with CDR (r=0.363, P=0.045) and ADAS-cog (r=0.449, P=0.019). Conclusion: Based on the observed correlation between IL-1Î±, as a clinical moiety, and ADAS-cog, as a clinical manifestation of AD, anti-IL-1Î± therapy in AD could be suggested. [GMJ.2021;10:e1974]
Major Dietary Patterns Are Associated with Acute Ischemic Stroke
Authors: Tabrizi Reza , Keshani Parisa , Jalali Mohammad , Estakhr Mehrdad , Sarihi Sorour , Kheirmandparizi Maryam , Azarpazhooh Reza , Borhani-Haghighi Afshin 
Published: December 2023

Background: Dietary patterns play an essential role in vascular diseases; however, the association of specific dietary patterns and the risk of stroke is unknown. We designed the current study to evaluate several dietary patterns and their association with ischemic stroke. Materials and Methods: This case-control study was performed on 300 subjects, including 150 cases with ischemic stroke admitted to a tertiary referral center in Shiraz, Southern Iran, and 150 age- and sex-matched stroke-free individuals as controls. Using a 62-item Simple Stroke Food Frequency Questionnaire (SS-FFQ), we collected data regarding the dietary habits of all the participants. We extracted the major dietary patterns via principal component analysis using the varimax rotation technique with Kaiser Normalization. Finally, adherence to dietary patterns among the participants was divided into quartiles. We investigated the association between dietary patterns and ischemic stroke using multiple logistic regression analyses. Results: One-hundred and fifty ischemic stroke patients (91 males and 59 females, mean age of 63.9Â±16.04 years) and 150 age- and sex-matched controls (91 males and 59 females, mean age of 61.99Â±16.04 years) were included. After adjusting five major dietary patterns for vascular risk factors, we found that diets rich in fibers and plant-based proteins (P<0.001) and micronutrients (P<0.001) had a lower odds of ischemic stroke as compared to high-fat proteins (P=0.003) and empty calories (P<0.001) diets, but consuming healthy animal proteins (P=0.115) had no effects on the occurrence of ischemic stroke. Conclusion: Based on our study, we suggest that fibers and plant-based proteins, and micronutrient diets could reduce the odds of stroke, so public awareness about the effects of different dietary patterns should be raised.
Imaging of Cerebral Venous and Sinus Thrombosis
Authors: Saadatnia Mohammad 
Published: December 2023

EarlyÂ Â and correct diagnosis of cerebral venous and sinus thrombosis (CVST) is necessary for prompt management of this disorder. Neuro-imaging is a crucial part of diagnosis of CVST.Â I reviewed the findings of non-enhanced computerized tomography (CT), Contrast enhanced CT, CT venography (CTV), different techniques of magnetic resonance imaging (MRI), MR venography, and digital subtraction angiography. I also reviewed the potential pitfalls in image interpretation.
Cerebral venous sinus thrombosis
Authors: Yadollahikhales Golnaz , Borhani-Haghighi Afshin , Safari Anahid , Wasay Mohammad , C.Edgell Randall 
Published: December 2023

Cerebral venous thrombosis (CVT) is occlusion of dural sinuses and/or cortical veins due to clot formation. It is a potentiallyÂ Â life-threatening condition that requires rapid diagnosis and urgent treatment.
Cerebral venous thrombosis is Â Â more common inÂ Â females and young people. Pregnancy, postpartum state, contraceptive pills,Â infection, malignancy, Â hyper-coagulable state, rheumatological disorders, trauma are among the major etiologies of cerebral venous thrombosis. Headache, focal neurologic deficits and seizure were the most common clinical presentations. Different techniques of unenhanced and contrast enhanced Â Â brainÂ computerized tomography(CT scan)Â and ,magnetic resonance imaging(MRI) are the most helpful ancillary investigations for diagnosis of Cerebral venous thrombosis.
Specific treatment Â of the underlying cause of cerebral venous thrombosis should be considered as the mainstay of the treatment. Anticoagulation with heparin or low molecular weight heparinoidsÂ is Â the most accepted treatment. In acute phase, medical Â Â or surgical management to decrease intracranial pressure (ICP) is Â Â also recommended. If the patient's clinicalÂ Â condition aggravates despite adequate anticoagulation, thrombolysis Â or mechanical thrombectomy can be an additive option.
Patients Characteristics and Preliminary Outcomes of Heart Failure Registry in A Middle-Income Country: Persian Registry of Cardiovascular Disease/Heart Failure (PROVE/HF)
Authors: Givi Mahshid , Shafie Davood , Garakyaraghi Mohammad , Yadegarfar Ghasem , Roohafza Hamid Reza , Ahmadi Seyed Abdellah , Nouri Fatemeh , Sarrafzadegan Nizal 
Published: December 2023

Background: The Persian Registry of Cardiovascular disease/Heart Failure (PROVE/HF) aimed to studied the demographic, clinical, and diagnostic characteristics and treatment of patients hospitalized for heart failure (HF) and to follow them for short- and long-term outcomes. Its pilot phase started in 2015 in Isfahan aiming to evaluate its feasibility to be scaled up at the national level in later stages. This article describes the method and preliminary results of the first year registry. Materials and Methods:Â Information of hospitalized patients with preserved and low ejection fraction, were gathered. Patients were followed for 1, 6, and 12 months. During follow-up, information of the patientsâ€™ current status, medications used during hospitalization, and in case of death, the cause and place were assessed. Result:Â PROVE/HF enrolled 787 patients in the first year. The mean age of patients was 70.74 Â±12.01 years, and 60.7% of them were men. The most frequent risk factors for the development of HF in the recruited patients was ischemic heart disease (77.9%), and hypertension (63.7%), respectively. The re-admission rate for patients with HF was at least once in 16% and continued until the fifth to ninth re-admission over a one-year period. Among 787 registered patients, 30.9% died in the first year of follow-up, and the in-hospital mortality was 6.2%. The mean hospitalization period was 4.88 days, and 64.2% were hospitalized for >3 days. Conclusion: The annual rate of re-admission and mortality was high, and the use of medication was less than the recommended one inaccordance with the guidelines for the treatment of heart failure.Â Â [GMJ.2018;7:e1026]Â
Genetic Variant of Glucocorticoid Receptor Gene at rs41423247 and Its Association with Major Depressive Disorder: A Case-Control Study
Authors: Firouzabadi Negar , Nouraei Hasti , Mandegary Ali 
Published: December 2023

Background:Â Extensive distribution of glucocorticoid receptors (GCRs) in different brain areas along with disruption of hypothalamic-pituitary-adrenal (HPA) axis in major depressive disorder (MDD) and the cross talk between GCRs and HPA proposes genetic variants of GC receptor genes as potential contributors in MDD. Among the GCR polymorphisms, rs41423247, rs6195 and rs6189/rs6190 are suggested to be involved in MDD.Materials and Methods:Â We investigated the association between rs41423247, rs6195 and rs6189/rs6190 and MDD in a case-control study. One hundred MDD patients along with 100 healthy individuals were enrolled in this study. genetic variants of rs41423247, rs6195 and rs6189/rs6190 were determined in extracted DNAs using PCR-RFLP.Result:Â The prevalence of heterozygote and mutant carriers of rs41423247 were significantly and by 1.9 fold greater in cases versus controls (P=0.033; OR; 95%CI=1.9; 1.1-3.3). Moreover, carriers of the mutant (G) allele were by 1.8 fold more prevalent in MDD group (P=0.013; OR;95%CI=1.8; 1.1-2.8).Conclusion:Â Specific carriers of rs41423247 might be more susceptible to developing MDD. This supports the hypothesis of the involvement of GCRs in pathophysiology of MDD.Â [GMJ.2018;7:e995]
Structural and Functional Analysis of Crucial Protein Complex in Basal Cell Skin Carcinoma via Network Construction
Authors: Zamanian Azodi Mona , Rezaei-Tavirani Mostafa , Rezaei-Tavirani Majid , Rostami-Nejad Mohammad 
Published: December 2023

Â Background: The basal-cell carcinoma (BCC) as one of the most common type of skin cancers reported to have an increasing trend during past years. Molecular approaches can be useful to advance diagnosis and treatment goals in this cancer.Materials and Methods: In this sense, one of the recent popular investigations, protein-protein interaction network analysis (PPI), wasÂ applied in this study to better facilitate molecular view of BCC. Â Cytoscape v3.6.0 and its plug-ins analyzed and explored the topological and annotation features of the constructed network.Â Result: Among TP53, EGFR, AKT1, ERBB2, HRAS, and CCND1 as central agents of the network, five of them were also present in the first prominent cluster of the network in which considered for further analysis. It is suggested that there are significant related biological processes, actions, and expression changes for this highlighted cluster that may be related to BCC risk.Â Â Conclusion: Therefore, the studied complex of proteins may worth considering for clinical studies and therapeutic interventions after validating by related tests. What is more, among these genes, EBBR2 has more to offer and consequently with additional values. Â [GMJ.2018;7:e1271]
Childbearing through the Lens of Women with Minor Thalassemia: A Qualitative Study
Authors: Sarayloo Khadijeh , Mirzaii Najmabadi Khadijeh , Behboodi Moghaddam Zahra , Saffari Mohsen , Millen Sharon Elizabeth 
Published: December 2023

Background: It is essential to provide key information and support to every woman regarding pregnancy and childbirth to enable all women to make a fully informed decision regarding their choice to reproduce.Â Of particular importance; however, is that women who suffer from a specific condition that increases risks associated with reproduction, to receive specific information regarding such risks and health complications regarding pregnancy and childbirth. This study aims to explore the feelings, experiences, and needs of women with minor thalassemia in relation to childbearing. Materials and Methods: This sample comprised of 12 Iranian women with minor thalassemia who attended to local health centers in Minudasht, Golestan province, from October 2017 to January 2018. The purposeful sampling technique was employed. The data were collected through deep semi-structured interviews, analyzed using conventional content analysis and processed by using the Graneheim and Lundman method. Results: The findings were based on the participantsâ€™ experiences of pregnancy and fertility. Three major themes emerged; â€˜Emotional and Physical Experience,â€™ â€˜Satisfactionâ€™ and â€˜Social and Cultural Issues.â€™ The most common problem identified was the impact of emotional problems and difficulties regarding the negative implications of thalassemia on reproduction as well as the views and perceptions of family members and those within the community. Conclusion: From the findings, it is evident that thalassemia imposes a heavy psychosocial burden on those women who suffer from the condition. Local health centers in areas most affected by thalassemia would be considered the most suitable venues to introduce key health educational interventions. [GMJ.2019;8:e1429]Â
A Genetic Association Study of MTHFR C677T Polymorphism with Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis
Authors: Azizi Soheil , Shamshirian Amir , Alizadeh-Navaei Reza , Jafarpour Hamed , Asemi Zatollah , Tamtaji Omid Reza , Vaziri Mohammad Sadegh , Homayounfar Reza , Rezaei Shahmirzadi Arash , Alipoor Reza 
Published: December 2023

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a crucial role as a methyl-group donor in demethylation of homocysteine. The aim of this systematic review and meta-analysis was to study the relationship between MTHFR gene polymorphism and metabolic syndrome (MS). We used search engines and databases such as Science Direct, Google Scholar, Embase, Cochrane Library, and PubMed to identify eligible studies up to 2018. The articles were studied based on keywords including MTHFR, mutation, variant, and polymorphism in combination with MS. Data was analyzed using Comprehensive Meta-Analysis version 2.2.064 software. After extracting the data from seven articles, the total number of subjects was 1280 in the patient group and 1374 in the control group. The odds ratio was estimated to be 1.078 for the allele model of T vs. C (95% confidence interval [CI]: 1.626-0.715), 1.157 for the allele model of CC vs. CT (95% CI: 0.829-1.615), 1.020 for the allele model of CT + TT vs. CC (95% CI: 1.611-0.646) and 0.799 for the allele model of TT vs. CC + CT (95% CI: 1.185-0.539). As well, the results showed no statistically significant correlation between polymorphism genotypes of the MTHFR gene and MS (P<0.05). In general, this study showed that the presence of C677T polymorphism in the MTHFR gene has no effect on the incidence of MS. [GMJ.2019;8:e1472]
Designing a Comprehensive Pattern of Structural-Psychological Empowerment for Employees of Medical Sciences Universities
Authors: Roohollahi Nayereh Sadat , Masoudi Asl Iravan , Hessam Somayeh , Mahmodi Mahmoud 
Published: December 2023

Background: The concept of empowerment requires the abandonment of traditional models. The need to design and develop employee empowerment patterns has been emphasized in several studies. The present study aims to design a comprehensive structural-psychological empowerment pattern for employees of medical sciences universities.Â Materials and Methods: Our exploratory research was conducted on 410 employees of medical universities of Tehran, Iran, and Islamic Azad University. Firstly, a primary pattern was designed according to a review of available literature, texts, patterns, and tools. Then, the psychometric analysis was done using validation (face validity, content validity, construct validity, factor validity) and reliability (internal consistency and stability). Lastly, the final pattern was introduced after having been approved by experts. Data were analyzed using SPSS version 24 and AMOS software. P<0.05 was considered as the significance level.Â Results: Based on our study, 83.9% of participants were holders of bachelor's degrees or higher degrees. The results of validation (face, content, structure, and confirmation validity) and reliability (internal consistency [Î±=0.90] and stability [0.91] ) showed that the structural-psychological empowerment pattern was appropriate, which was validated with 31 items and 8 domains. The scope of this pattern included resources, self-sufficiency, competence, support, effectiveness, and opportunity, significance, and information domains. The highest impact on the model was related to the support domain (impact factor=0.87).Â Conclusion: The present pattern is an appropriate and verified Iranian model in the field of structural-psychological empowerment, which is suggested in the cultural context of Iran, especially in medical universities.[GMJ.2019;8:e1486]Â
Depression Among First- and Fifth-Year Medical Students in Riyadh, Saudi Arabia
Authors: Almalki Abdulaziz Saeed , Almalki Abdullah , Kokandi Abdullah , Aldosari Bandar , Bin Baz Abdulaziz , Alfadhel Shoog , Alsuwayyigh Abdulaziz , Alsadoun Rgad , Haddad Bandar 
Published: December 2023

Background: Depression, which is characterized by persistent sadness, is a highly prevalent and serious medical disease that affects more than 300 million individuals worldwide. It is hypothesized that the onset of depressive symptoms in medical students occurs due to prolonged exposure to the stressful environment of medical colleges. Hence, we aimed to determine the presence of depressive symptoms and compare the level of depression between the first-year and fifth-year medical students in Riyadh city, Saudi Arabia.Â Materials and Methods: This cross-sectional study was performed with convenient sampling from 2 medical colleges in Riyadh in the Kingdom of Saudi Arabia from October to November 2017. The English version of Beckâ€™s Depression Inventory questionnaire was used in this study. Statistical analysis was administered using SPSS via chi-square test, and P-value less than 0.05 was considered statistically significant.Â Results: The questionnaire was answered by 241 participants. The age variable shows a bimodal distribution. The mean age of first-year and fifth-year students was 19Â±0.8 years and 23Â±2.1 years, respectively. Fifth-year students comprised 53.5% of the total sample, and male students accounted for 63.1% of the total sample. After analysis, the results show that male students scored higher than female students on the lower side of the scale in both years. Most of the first-year female students scored a higher level of depression compared with male students (P=0.001), whereas no difference between males and females (P=0.04) was found in the fifth-year studentsâ€™ data.Â Conclusion: Our study shows a new pattern of reported depressive symptoms among first- and fifth-year medical students. In addition, the study suggests that depression is more common in female medical students as compared with their male counterparts. For future studies, we recommend using randomized sampling in a cohort study including all levels of medical students to further investigate and confirm the findings.[GMJ.2019;8:e1497]