bluuebunny/crossref_metadata_2025_split huggingface dataset:
New trials in resistant hypertension: mixed blessing stories
Authors: Zoccali Carmine , Mallamaci Francesca , De Nicola Luca , Minutolo Roberto 
Published: September 2023

ABSTRACT
Resistant hypertension (RH) is linked to an increased risk of cardiovascular and renal complications. Treatment options include non-pharmacological interventions, such as lifestyle modifications, and the use of specific antihypertensive drug combinations, including diuretics. Renal denervation is another option for treatment-resistant hypertension. New compounds targeting different pathways involved in RH—including inhibitors of aminopeptidase A, endothelin antagonists and selective aldosterone synthase inhibitors—have been tested in clinical trials in this condition. The centrally acting drug firibastat, targeting the brain renin–angiotensin system, failed to demonstrate significant effectiveness in reducing blood pressure (BP) in patients with difficult-to-treat and RH in the Firibistat in Resistant Hypertension (FRESH) trial. Aprocitentan, a dual endothelin A and B receptor antagonist, showed a moderate but statistically significant decrease in BP in patients with RH in the Parallel-Group, Phase 3 Study with Aprocitentan in Subjects with Resistant Hypertension (PRECISION) trial. However, concerns remain about potential adverse events, such as fluid retention. The use of baxdrostat, a selective aldosterone synthase inhibitor, showed promising results in reducing BP in patients with treatment-resistant hypertension in the Baxdrostat in Resistant Hypertension (BrigHTN) trial. However, a subsequent trial, HALO, failed to meet its primary endpoint. The unexpected results may be influenced by factors such as patient adherence and white-coat hypertension. Despite the disappointing results from HALO, the potential benefits of inhibiting aldosterone synthesis remain to be fully understood. In conclusion, managing RH remains challenging, and new compounds like firibastat, aprocitentan and baxdrostat have shown varied effectiveness. Further research is needed to improve our understanding and treatment of this condition.
Smartphone-based atrial fibrillation screening in the general population: feasibility and impact on medical treatment
Authors: Gruwez Henri , Verbrugge Frederik H , Proesmans Tine , Evens Stijn , Vanacker Peter , Rutgers Matthieu Pierre , Vanhooren Geert , Bertrand Philippe , Pison Laurent , Haemers Peter , Vandervoort Pieter , Nuyens Dieter 
Published: September 2023

Abstract

Aims
The aim of this study is to determine the feasibility, detection rate, and therapeutic implications of large-scale smartphone-based screening for atrial fibrillation (AF).

Methods and results
Subjects from the general population in Belgium were recruited through a media campaign to perform AF screening during 8 consecutive days with a smartphone application. The application analyses photoplethysmography traces with artificial intelligence and offline validation of suspected signals to detect AF. The impact of AF screening on medical therapy was measured through questionnaires. Atrial fibrillation was detected in the screened population (n = 60.629) in 791 subjects (1.3%). From this group, 55% responded to the questionnaire. Clinical AF [AF confirmed on a surface electrocardiogram (ECG)] was newly diagnosed in 60 individuals and triggered the initiation of anti-thrombotic therapy in 45%, adjustment of rate or rhythm controlling strategies in 62%, and risk factor management in 17%. In subjects diagnosed with known AF before screening, a positive screening result led to these therapy adjustments in 9%, 39%, and 11%, respectively. In all subjects with clinical AF and an indication for oral anti-coagulation (OAC), OAC uptake increased from 56% to 74% with AF screening. Subjects with clinical AF were older with more co-morbidities compared with subclinical AF (no surface ECG confirmation of AF) (P &lt; 0.001). In subjects with subclinical AF (n = 202), therapy adjustments were performed in only 7%.

Conclusion
Smartphone–based AF screening is feasible at large scale. Screening increased OAC uptake and impacted therapy of both new and previously diagnosed clinical AF but failed to impact risk factor management in subjects with subclinical AF.
The First High-Quality Chromosome-Level Genome of the Lutjanus erythropterus (Bloch, 1790) Using Single-Tube Long Fragment Reads and Hi-C Technologies
Authors: Lai Zhuoxin , Afriyie Gyamfua , Cui Haitao , Chen Lujun , Xu Zhenmin , Chen Zizhao , Liang Quilu , Luo Jie , Dong Zhongdian , Shao Changwei , Guo Yusong , Wang Zhongduo 
Published: September 2023

Abstract
Lutjanus erythropterus (Bloch, 1790), a Perciformes from the Lutjanidae family, is a commercially important species because of its taste and abundance. Despite the increase in genome resources in recent years, few genome assemblies are available within this fish family for comparative and functional studies. In this study, we determined the chromosomal genome of Crimson snapper using high-throughput Single-Tube Long Fragment Reads sequencing technology and Hi-C data. The final assembly size was 973.04 Mb with contig and scaffold N50 values of 1.51 and 40.65 Mb, respectively. We successfully scaffolded 95.84% of the genome sequence onto 24 chromosomes ranging in length from 19.37 to 49.48 Mb. A total of 22,663 genes and 13,877 gene families were identified in the genome, with 29 gene families being L. erythropterus-specific. A phylogenetic analysis using single-copy gene families showed that L. erythropterus and Larimichthys crocea had the closest genetic relationship with a divergence time of ∼47.7 Ma. This new genomic resource will facilitate comparative genomic studies as well as genetic breeding programs for L. erythropterus.
Revised fission yeast gene and allele nomenclature guidelines for machine readability
Authors: Lera-Ramírez Manuel , Bähler Jürg , Mata Juan , Rutherford Kim , Hoffman Charles S , Lambert Sarah , Oliferenko Snezhana , Martin Sophie G , Gould Kathleen L , Du Li-Lin , Sabatinos Sarah A , Forsburg Susan L , Nielsen Olaf , Nurse Paul , Wood Valerie 
Published: September 2023

Abstract
Standardized nomenclature for genes, gene products, and isoforms is crucial to prevent ambiguity and enable clear communication of scientific data, facilitating efficient biocuration and data sharing. Standardized genotype nomenclature, which describes alleles present in a specific strain that differ from those in the wild-type reference strain, is equally essential to maximize research impact and ensure that results linking genotypes to phenotypes are Findable, Accessible, Interoperable, and Reusable (FAIR). In this publication, we extend the fission yeast clade gene nomenclature guidelines to support the curation efforts at PomBase (www.pombase.org), the Schizosaccharomyces pombe Model Organism Database. This update introduces nomenclature guidelines for noncoding RNA genes, following those set forth by the Human Genome Organisation Gene Nomenclature Committee. Additionally, we provide a significant update to the allele and genotype nomenclature guidelines originally published in 1987, to standardize the diverse range of genetic modifications enabled by the fission yeast genetic toolbox. These updated guidelines reflect a community consensus between numerous fission yeast researchers. Adoption of these rules will improve consistency in gene and genotype nomenclature, and facilitate machine-readability and automated entity recognition of fission yeast genes and alleles in publications or datasets. In conclusion, our updated guidelines provide a valuable resource for the fission yeast research community, promoting consistency, clarity, and FAIRness in genetic data sharing and interpretation.
Post-seismic gravity change modelling based on non-linear power-law upper mantle rheology
Authors: Yan Changda , Miyazaki Shin’ichi 
Published: September 2023

SUMMARY
Post-seismic gravity change modelling is commonly based on earth model with Newtonian linear rheology. Here, we present a novel way of modelling post-seismic gravity change by using a non-linear power-law rheology earth model. The method is constructed based on the framework of spectral finite element method (SFEM). SFEM has been proven practical for the purpose of modelling gravity change occurring during megathrust earthquakes. Our method implements the strain rate expression of non-linear power-law rheology into the mathematical framework of SFEM. Using our method, simulations of geoid change caused by synthetic point source earthquakes were made. The results revealed the potential of using non-linear power-law rheology for the explanation of rapid gravity changes in the beginning of the post-seismic epoch. Further on, we computed the post-seismic gravity change of the 2011 M9.0 Tohoku-Oki earthquake based on Maxwell non-linear power-law rheology in the upper mantle. It demonstrated the potential of power-law upper mantle flow as a possible candidate for the explanation of post-seismic gravity change after the earthquake occurs. However, a Maxwell non-linear power-law rheology alone is insufficient for the explanation of the post-seismic gravity change occurred.
Temporal, environmental, and demographic correlates of Ichthyophonus sp. infections in mature Pacific herring populations
Authors: Groner M L , Bravo-Mendosa E D , MacKenzie A H , Gregg J L , Conway C M , Trochta J T , Hershberger P K 
Published: September 2023

Abstract
Causes of population collapse and failed recovery often remain enigmatic in marine forage fish like Pacific herring (Clupea pallasii) that experience dramatic population oscillations. Diseases such as ichthyophoniasis are hypothesized to contribute to these declines, but lack of long-term datasets frequently prevents inference. Analysis of pathogen surveillance and population assessment datasets spanning 2007–2019 indicate that the age-based prevalence estimate of Ichthyophonus infection was, on average, 54% greater among a collapsed population of Pacific herring (Prince William Sound, Alaska, USA) as compared to a nearby population (Sitka Sound, Alaska, USA) that is relatively robust. During the study years, the age-based infection prevalence ranged from 14 to 44% in Prince William Sound and 5 to 33% in Sitka Sound. At both sites, the age-based infection prevalence declined over time, with an average decrease of 7% per year. Statistical analyses indicated that infection prevalence between the two populations was reduced by regional factors affecting both sites, and that these factors were independent of herring density. Infection prevalence in both populations was positively correlated with herring age and negatively correlated with the Pacific Decadal Oscillation. This study demonstrates how synthesis of environmental, stock assessment, and disease assessment data can be leveraged to elucidate epidemiological trends in diseases of wild fish.
Can the European Financial Data Space remove bias in financial AI development? Opportunities and regulatory challenges
Authors: Chomczyk Penedo Andrés , Trigo Kramcsák Pablo 
Published: September 2023

Abstract
The EU data economy’s growth hinges on access to extensive data, with open banking initiatives encouraging data sharing in the financial services industry. Artificial intelligence (AI)-driven tools play a vital role in harnessing the potential of this data, but training these systems carries inherent risks, including the introduction of new or the perpetuation of existing biases. This article examines the role of the European Financial Data Space (EFDS) in AI training, using consumer creditworthiness evaluation as a case study. It investigates whether the EFDS facilitates responsible AI development, considering data protection concerns like legal basis, transparency and control. The objective is to enhance the regulatory proposal for the EFDS, ensuring a well-founded legal framework for utilizing AI responsibly in the financial sector within the broader context of European Data Spaces.
Integrative Analyses of scRNA-seq, Bulk mRNA-seq, and DNA Methylation Profiling in Depressed Suicide Brain Tissues
Authors: Zhou Yalan , Xiong Lan , Chen✉ Jianhua , Wang✉ Qingzhong 
Published: September 2023

Abstract

Background
Suicidal behaviors have become a serious public health concern globally due to the economic and human cost of suicidal behavior to individuals, families, communities, and society. However, the underlying etiology and biological mechanism of suicidal behavior remains poorly understood.

Methods
We collected different single omic data, including single-cell RNA sequencing (scRNA-seq), bulk mRNA-seq, DNA methylation microarrays from the cortex of Major Depressive Disorder (MDD) in suicide subjects’ studies, as well as fluoxetine-treated rats brains. We matched subject IDs that overlapped between the transcriptome dataset and the methylation dataset. The differential expression genes and differentially methylated regions were calculated with a 2-group comparison analysis. Cross-omics analysis was performed to calculate the correlation between the methylated and transcript levels of differentially methylated CpG sites and mapped transcripts. Additionally, we performed a deconvolution analysis for bulk mRNA-seq and DNA methylation profiling with scRNA-seq as the reference profiles.

Results
Difference in cell type proportions among 7 cell types. Meanwhile, our analysis of single-cell sequence from the antidepressant-treated rats found that drug-specific differential expression genes were enriched into biological pathways, including ion channels and glutamatergic receptors.

Conclusions
This study identified some important dysregulated genes influenced by DNA methylation in 2 brain regions of depression and suicide patients. Interestingly, we found that oligodendrocyte precursor cells (OPCs) have the most contributors for cell-type proportions related to differential expression genes and methylated sites in suicidal behavior.
Logarithmic Prismatic Cohomology via Logarithmic THH
Authors: Binda Federico , Lundemo Tommy , Park Doosung , Østvær Paul Arne 
Published: September 2023

Abstract
Inspired by Bhatt–Morrow–Scholze’s work on $\textrm{THH}$, we define Nygaard-completed log prismatic cohomology based on log topological Hochschild homology via filtrations on log $\textrm{THH}$ and its variants. Moreover, of independent interest, we describe log $\textrm{THH}$ for quasiregular semiperfectoid pre-log rings as a $1$-parameter deformation of ordinary, non-logarithmic Hochschild homology.
Measuring quality of care for universal health coverage in the Western Pacific
Authors: Loreche Arianna Maever , Pepito Veincent Christian F , Hartigan-Go Kenneth Y , Dayrit Manuel M 
Published: September 2023

Abstract
To deliver on the promise of universal health coverage, regions and countries need to invest in high-quality health systems and put quality of care at the forefront of priority setting and agenda. The Western Pacific Region and its member countries should establish measurements and standards to ensure delivery of high-quality services. In order to effectively do so, individual and system capacities to measure and use quality-of-care data should be strengthened, localized initiatives to develop quality-of-care measures of practice and policy relevance need to be carried out, accountability mechanisms should be in place, and the role of quality as a driver of better health outcomes and economic benefits should be emphasized among all stakeholders. Such initiatives will ensure that quality-of-care measures are “measurements for action” toward quality improvement and reform.
Narratology and US Foreign Policy in Syria: Beyond Identity Binaries, toward Narrative Power
Authors: Holland Jack , Mathieu Xavier 
Published: September 2023

Abstract
Narrative approaches have recently gained popularity in International Relations (IR), albeit often with a focus on instrumentality. This article analyzes the “value added” of narratology, complementing IR’s existing focus on strategic narratives, by focusing on what it is that sets stories apart from other linguistic features. The article develops three contributions. First, we demonstrate that narratology contributes to efforts in IR to move beyond a propensity for identity binaries, analyzing the more nuanced relational identities that are formed within the web of characters that populate stories. Second, we theorize (structural) narrative power, conceptualizing how stories project and propel forward through time to guide policy. Our take on (structural) narrative power emphasizes audience expectations of narrative closure as creating a teleological impulse. This is narrative power—the life of stories. We mobilize this conceptual framework, analyzing US foreign policy during the early Syrian Civil War, with a focus on the war’s storying and the writing of its characters across 600+ policy and media texts. Third, our article locates (the flaws and paradoxes of) US policy within the narrative power of its story, established in the war’s opening chapters.
Type Realism Reconsidered
Authors: Irmak Nurbay 
Published: September 2023

Abstract
Realism about types is the view that types are abstract and repeatable objects. Although type realists seem to agree that types, unlike properties, are objects in their own right, they argue that there is a metaphysically intimate tie between the existence conditions of types and properties. In particular, most type realists believe that types are, in a certain sense, determined by the properties that underlie them. I argue that this is a mistake, especially for those type realists who believe that social and cultural types such as works of music and fiction or words are artifacts. I offer an alternative version of type realism where social and cultural types are dependent objects that should be understood in analogy with concrete artifacts.
GC-MS Analysis of Primary Aromatic Amines Originated From Azo Dyes in Commercial Textile or Leather Products Using Helium Alternative Carrier Gases
Authors: Tahara Maiko , Kawakami Tsuyoshi , Ikarashi Yoshiaki 
Published: September 2023

Abstract

Background
In recent years, due to the global shortage of helium gas, the development of gas chromatography (GC) analytical methods using alternatives to helium carrier gases is necessary.

Objective
The objective of this study was to examine the applicability of hydrogen and nitrogen as alternative carrier gases using the test method for azo compounds in the Act on Control of Household Products Containing Harmful Substances of Japan.

Method
The gas chromatograph mass spectrometer (GC-MS) analytical method using hydrogen and nitrogen as alternative carrier gases was compared with a method using helium for 26 primary aromatic amines (PAAs) originated from azo dyes.

Results
When hydrogen and nitrogen were used as carrier gases under the same conditions used during analysis using helium (same column, gas flow rate, oven temperature conditions, etc.), sufficient peak separation of 26 PAAs was obtained. The sensitivities of the methods using helium and hydrogen were comparable, whereas the sensitivity was lower when nitrogen was used, with the detection limits ranging from 1/220 to 1/25. However, all carrier gases achieved quantification at concentrations below the standard value (30 μg/g) of the Act on Control of Household Products Containing Harmful Substances, and the results were in agreement with the standard value for the target product.

Conclusions
Our results indicated that hydrogen or nitrogen can be used as alternative carrier gases to helium for GC-MS analysis of azo compounds producing specific aromatic amines.

Highlights
Using hydrogen or nitrogen as an alternative carrier gas to helium, azo compounds could be quantified with excellent accuracy.
High-performance liquid chromatography–tandem mass spectrometry method for measuring cotinine and trans-3′-hydroxycotinine in bronchoalveolar lavage fluid of patients with e-cigarette, or vaping, product use-associated lung injury
Authors: Seyler Tiffany , Blount Benjamin C , Wang Lanqing 
Published: September 2023

Abstract
In 2019, nearly 3000 U.S. residents developed severe lung injury associated with recent use of e-cigarette or vaping products. The Centers for Disease Control and Prevention responded to the outbreak, which was formally defined as e-cigarette, or vaping, product use-associated lung injury (EVALI). Centers for Disease Control and Prevention Laboratory rapidly developed assays to analyze potentially harmful and addictive substances in bronchoalveolar lavage (BAL) fluid collected from EVALI case patients. This report describes the development and validation of a high-throughput isotope-dilution high performance liquid chromatography–tandem mass spectrometry method for measuring two nicotine biomarkers, cotinine (COT) and trans-3′-hydroxycotinine (HCT), in bronchoalveolar lavage fluid samples. COT and HCT are the major metabolites of nicotine, the addictive alkaloid presents in tobacco products. This method had good specificity and sensitivity. The limit of detection is 0.033 and 0.0165 ng/mL for COT and HCT, respectively, using only 200 µL of sample volume. The within-run and between-run precision were 2–10%. The overall accuracy, calculated from recovery in three different sample matrices spiked at three concentrations, was 94.8% and 93.6% for COT and HCT, respectively. This novel HPLC–MS-MS method was utilized to characterize recent tobacco exposure in EVALI case patients. This method is useful for characterizing tobacco exposure that may be related to acute and chronic lung injury.
Gastroscopy for dyspepsia: Understanding primary care and gastroenterologist mental models of practice: A cognitive task analysis approach
Authors: Barber Tanya , Crick Katelynn , Toon Lynn , Tate Jordan , Kelm Karen , Novak Kerri , Yeung Rose O , Tandon Puneeta , Sadowski Daniel C , Veldhuyzen van Zanten Sander , Campbell-Scherer Denise 
Published: September 2023

Abstract

Background
Gastroscopy to investigate dyspepsia without alarm symptoms rarely results in clinically actionable findings or sustained health-related quality-of-life improvements among patients aged 18–60 years and is, therefore, not recommended. Despite this, referrals for and performance of gastroscopy among this patient population remain high. The purpose of this study was to understand family physicians’ and gastroenterologists’ mental models of dyspepsia and the drivers behind referring or performing gastroscopy.

Methods
Cognitive task analysis routine critical decision method interviews with family physicians (n = 8) and gastroenterologists (n = 4).

Results
Family physicians and gastroenterologists hold rich mental models of dyspepsia that rely on sensemaking; however, gaps in information continuity affect their ability to plan and coordinate patient care. Drivers behind decisions to refer or perform gastroscopy were: eliminating risk for serious pathology, providing reassurance, perceived preference by patients to receive information and reassurance from gastroenterologists, maintaining relationships with patients, and saving costs to the health system.

Conclusions
Family physicians refer for dyspepsia when they are seeking support from gastroenterologists, they believe that alternative factors may be impacting the patient’s health or view it as a cost-saving measure. Likewise, gastroenterologists perform gastroscopy for dyspepsia when they perceive it as a cost-saving measure, they want to support their primary care colleagues and provide their colleagues and patients with reassurance. An improved degree of communication between speciality and primary care could allow for continuity in the transfer of information about patients and reduce referrals for dyspepsia.