bluuebunny/crossref_metadata_2025_split huggingface dataset:
“OUR NATION’S DEMOCRACY IS AT A CRITICAL CROSSROAD”: OLDER ADULTS TAKING ACTION AND LEADING COMMUNITY ENGAGEMENT
Authors: Perry Tam , Rorai Vanessa , Whitney Sarah , Stringer Wilma , Swift Henry , Bridgforth James , Mullin Patricia 
Published: December 2023

Abstract
Launched by older Black adults from the Healthier Black Elders Center (HBEC) of the Michigan Center for Urban African American Aging Research, Critical Crossroads was created to engage older Detroiters in community conversations, advocacy, and strategies around issues of social injustice. Critical Crossroads provides older adults a space to discuss what concerns them at both national and local community levels, share their personal impact stories and experiences, and learn how these issues connect to social determinants of health. One important feature of this program has been attention to concerns of housing and its impact on older adults. This presentation will highlight two Critical Crossroads housing related segments (e.g., CDC moratorium on eviction, applying for FEMA aid for flooding). This presentation will share the This presentation will share the development of this community-led initiative, program goals, and lessons learned.
SO MANY STAKEHOLDERS, SO MANY CONTRACTS!
Authors: DeLiema Marguerite 
Published: December 2023

Abstract
Elder financial fraud is a growing challenge for adult protective services (APS), financial institutions, and state and federal law enforcement agencies that seek effective interventions to protect older adults from continued financial loss. One solution is temporary account holds that prevent suspicious withdrawals from an older or vulnerable adult’s account while investigation and additional interventions are put in place. With funding from the Administration for Community Living, this project seeks to understand the outcomes of temporary account holds on elder safety and financial autonomy in Minnesota. We first worked to improve communication between APS and other Minnesota state agencies to ensure that cases are properly referred and that protection activities are coordinated to achieve the best outcomes for the older adult. Like most collaborative research projects that involve university researchers and state agencies, significant legal agreements were necessary. Multiple subawards and cost share agreements were drafted, data use agreements were created, and IRB approvals from multiple entities were sought. In this presentation, Dr. DeLiema will share lessons learned about how researchers can better prepare for the administrative burden and delayed starts associated with completing these legal administrative processes. She will describe common areas of conflict and competing interests between state agencies and universities around data privacy and ownership, strategies for finding common ground, and possible workarounds to fulfill project aims. Dr. DeLiema will also highlight how to “pitch” a collaboration to community stakeholders using a value proposition that outlines the benefits of the project to the stakeholder.
CONTEXTUAL FACTORS THAT SHAPE EXPERIENCES OF SEXUAL INTIMACY AMONG LATER-LIFE COUPLES
Authors: Yorgason Jeremy , Wilson Stephanie , Liu Hui (Cathy) 
Published: December 2023

Abstract
Sexuality is an important aspect of romantic dyadic relationships. Although people experience physical changes with age that result in changes in sexual interactions, the sexual aspect of couple relationships remain important. Research examining sexuality among later life couples is maturing, allowing investigators to explore more nuanced questions about couple contexts that shape sexual experiences. The current group of papers address some of these important contextual factors that can impact the couple sexual relationship, including sexual motives among same and different sex couples, personality characteristics and how they relate to sexual interactions, how couples’ sexual interactions are affected by transitions such as menopause, and how sleep patterns among caregivers are related to sexual interactions. Presenters in this session draw upon national studies of older adults including NSHAP, MIDUS, and HARP. They used advanced statistical modeling to explore their questions. Findings suggest that self-determined sexual motives among same and different sex couples were associated with better marital quality and lower depression. The menopause transition, along with relationship transitions in later life, were associated with sexual interactions. Conscientiousness and neuroticism were associated with sexual pleasure and emotional satisfaction, along with preferences regarding physical touch within the relationship. Among caregivers, sleep duration was less important; sharing a bed with a care-recipient partner was associated with physical pleasure; and napping was negatively associated with sexual quality. In summary, various factors impact the sexual interactions of older couples in different ways. Findings from these papers given nuanced insight into a number of important contextual factors.
DataColor: unveiling biological data relationships through distinctive color mapping
Authors: He Shuang , Dong Wei , Chen Junhao , Zhang Junyu , Lin Weiwei , Yang Shuting , Xu Dong , Zhou Yuhan , Miao Benben , Wang Wenquan , Chen Fei 
Published: December 2023

AbstractIn the era of rapid advancements in high-throughput omics technologies, the visualization of diverse data types with varying orders of magnitude presents a pressing challenge. To bridge this gap, we introduce DataColor, an all-encompassing software solution meticulously crafted to address this challenge. Our aim is to empower users with the ability to handle a wide array of data types through an assortment of tools, while simultaneously streamlining parameter selection for rapid insights and detailed enhancements. DataColor stands as a robust toolkit, encompassing 23 distinct tools coupled with over 600 parameters. The defining characteristic of this toolkit is its adept utilization of the color spectrum, allowing for the representation of data spanning diverse types and magnitudes. Through the integration of advanced algorithms encompassing data clustering, normalization, squarified layouts, and customizable parameters, DataColor unveils an abundance of insights that lay hidden within the intricate relationships embedded in the data. Whether you find yourself navigating the analysis of expansive datasets or embarking on the quest to visualize intricate patterns, DataColor stands as the comprehensive and potent solution. We extend the availability of DataColor to all users at no cost, accessible through the following link: https://github.com/frankgenome/DataColor.
Guidance for reporting analyses of metadata on electronic health record use
Authors: Rule Adam , Kannampallil Thomas , Hribar Michelle R , Dziorny Adam C , Thombley Robert , Apathy Nate C , Adler-Milstein Julia 
Published: December 2023

Abstract

Introduction
Research on how people interact with electronic health records (EHRs) increasingly involves the analysis of metadata on EHR use. These metadata can be recorded unobtrusively and capture EHR use at a scale unattainable through direct observation or self-reports. However, there is substantial variation in how metadata on EHR use are recorded, analyzed and described, limiting understanding, replication, and synthesis across studies.

Recommendations
In this perspective, we provide guidance to those working with EHR use metadata by describing 4 common types, how they are recorded, and how they can be aggregated into higher-level measures of EHR use. We also describe guidelines for reporting analyses of EHR use metadata—or measures of EHR use derived from them—to foster clarity, standardization, and reproducibility in this emerging and critical area of research.
Using Computer Vision and Artificial Intelligence to Track the Healing of Severe Burns
Authors: Ethier Olivier , Chan Hannah O , Abdolahnejad Mahla , Morzycki Alexander , Fansi Tchango Arsene , Joshi Rakesh , Wong Joshua N , Hong Collin 
Published: December 2023

Abstract
Burn care management includes assessing the severity of burns accurately, especially distinguishing superficial partial-thickness burns from deep partial-thickness burns, in the context of providing definitive, downstream treatment. Moreover, the healing of the wound in the subacute care setting requires continuous tracking to avoid complications. Artificial intelligence (AI) and computer vision (CV) provide a unique opportunity to build low-cost and accessible tools to classify burn severity and track changes in wound parameters, both in the clinic by physicians and nurses and asynchronously in the remote setting by the patient themselves. Wound assessments can be achieved by AI–CV using the principles of image-guided therapy using high-quality 2D color images. Wound parameters can include wound 2D spatial dimension and the characterization of wound color changes, which demonstrates physiological changes such as the presentation of eschar/necrotic tissue, pustulence, granulation tissue, and scabbing. Here we present the development of AI–CV-based Skin Abnormality Tracking Algorithm pipeline. Additionally, we provide the results on a single localized burn tracked for a 6-week period in the clinic and an additional 2-week period of home monitoring.
In search of excellence
Authors: Field Richard E 
Published: December 2023

ABSTRACT
A little while ago, I had the opportunity to spend some time in the operating room (theatre) of one of the world’s most experienced and technically skilful hip arthroscopists. How I wish I had made the effort to visit this surgeon earlier in my career and how I regret that there are still so many surgeons I have failed to visit. Every surgeon who has allowed me into their operating room has shown me something that has enhanced my practice and learning to execute their manoeuvres always adds to the pleasure of surgical practice.
The energy transition at a critical juncture
Authors: Hailes Oliver , Viñuales Jorge E 
Published: December 2023

Abstract
Amid the Ukraine war, the energy transition has reached a critical juncture: decisions taken by key governmental or commercial actors may irreversibly threaten efforts to limit the rise in global average temperature to 1.5°C. After defining the notions of ‘energy transition’ and ‘critical juncture’, this article describes how the ‘international law of energy’ may both entrench a socio-technical regime based on fossil fuels and promote the transition towards renewable energy. These categories serve to frame several contributions to a symposium, which assist in mapping the rules, processes, and institutions that organize the decisional options of key actors as they try to drive the energy transition through this critical juncture. We conclude by recalling the practical utility of this dynamic map and the pressing need for an authoritative compass to give interpretive direction to the legal organization of the entitlements, obligations, and decisional options of key actors in reorienting energy activities to avoid the catastrophic tipping points of climate change.
Cxcl1 monomer–dimer equilibrium controls neutrophil extravasation
Authors: León-Vega Iliana I , Vadillo Eduardo , Vargas-Robles Hilda , Rajarathnam Krishna , Schnoor Michael 
Published: December 2023

Abstract
The chemokine Cxcl1 plays a crucial role in recruiting neutrophils in response to infection. The early events in chemokine-mediated neutrophil extravasation involve a sequence of highly orchestrated steps including rolling, adhesion, arrest, and diapedesis. Cxcl1 function is determined by its properties of reversible monomer–dimer equilibrium and binding to Cxcr2 and glycosaminoglycans. Here, we characterized how these properties orchestrate extravasation using intravital microscopy of the cremaster. Compared to WT Cxcl1, which exists as both a monomer and a dimer, the trapped dimer caused faster rolling, less adhesion, and less extravasation. Whole-mount immunofluorescence of the cremaster and arrest assays confirmed these data. Moreover, the Cxcl1 dimer showed impaired LFA-1–mediated neutrophil arrest that could be attributed to impaired Cxcr2-mediated ERK signaling. We conclude that Cxcl1 monomer–dimer equilibrium and potent Cxcr2 activity of the monomer together coordinate the early events in neutrophil recruitment.
Spontaneous gastric perforation complicating acute laryngotracheobronchitis in an infant: a novel case report from Nepal
Authors: Paudyal Nabin , Devkota Yogendra , Shah Sanjay Kumar , Gami Barsha , Regmi Prakriti 
Published: December 2023

Abstract
Pediatric spontaneous gastric perforation is a rarely encountered condition with poorly understood causal mechanisms. We present a novel case of a two-month-old female infant from Nepal who previously experienced Croup and subsequently developed severe abdominal distention and vomiting. Abdominal X-ray findings confirmed pneumoperitoneum, prompting immediate laparotomy. Intraoperative examination revealed a substantial perforation along the posterior stomach wall, specifically along the lesser curvature. The surgical intervention involved gastrorrhaphy and omentopexy using 3-0 Vicryl sutures, leading to an uneventful postoperative recovery. This case report highlights the critical importance of early and efficient management of spontaneous gastric perforations in infants, emphasizing the need for timely intervention to achieve favorable outcomes. Pediatric spontaneous gastric perforation remains a rare condition, and reporting such cases contributes to our understanding and management of this unusual pathology.
A Catch-22—The Test–Retest Method of Reliability Estimation
Authors: Tufiş Paula A , Alwin Duane F , Ramírez Daniel N 
Published: December 2023

Abstract
This article addresses the problems with the traditional reinterview approach to estimating the reliability of survey measures. Using data from three reinterview (or panel) studies conducted by the General Social Survey, we investigate the differences between the two-wave correlational approach embodied by the traditional reinterview strategy, compared to estimates of reliability that take the stability of traits into account based on a three-wave model. Our results indicate that the problems identified with the two-wave correlational approach reflect a kind of “Catch-22” in the sense that the only solution to the problem is denied by the approach itself. Specifically, we show that the correctly specified two-wave model, which includes the potential for true change in the latent variable, is underidentified, and thus, unless one is willing to make some potentially risky assumptions, reliability parameters are not estimable. This article compares the two-wave correlational approach to an alternative model for estimating reliability, Heise’s estimates based on the three-wave simplex model. Using three waves of data from the GSS panels, which were separated by 2-year intervals between waves, this article examines the conditions under which the wave-1, wave-2 correlations which do not take stability into account approximate the reliability estimate obtained from three-wave simplex models that do take stability into account. The results lead to the conclusion that the differences between estimates depend on the stability and/or fixed nature of the underlying processes involved. Few if any differences are identified when traits are fixed or highly stable, but for traits involving changes in the underlying traits the differences can be quite large, and thus, we argue for the superiority of reinterview designs that involve more than 2 waves in the estimation of reliability parameters.
Improved Assessment of Schistosoma Community Infection Through Data Resampling Method
Authors: Gurarie David , Mondal Anirban , Ndeffo-Mbah Martial L 
Published: December 2023

Abstract

Background
The conventional diagnostic for Schistosoma mansoni infection is stool microscopy with the Kato-Katz (KK) technique to detect eggs. Its outcomes are highly variable on a day-to-day basis and may lead to biased estimates of community infection used to inform public health programs. Our goal is to develop a resampling method that leverages data from a large-scale randomized trial to accurately predict community infection.

Methods
We developed a resampling method that provides unbiased community estimates of prevalence, intensity and other statistics for S mansoni infection when a community survey is conducted using KK stool microscopy with a single sample per host. It leverages a large-scale data set, collected in the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) project, and allows linking single—stool specimen community screening to its putative multiday “true statistics.”

Results
SCORE data analysis reveals the limited sensitivity of KK stool microscopy and systematic bias of single-day community testing versus multiday testing; for prevalence estimate, it can fall up to 50% below the true value. The proposed SCORE cluster method reduces systematic bias and brings the estimated prevalence values within 5%–10% of the true value. This holds for a broad swath of transmission settings, including SCORE communities, and other data sets.

Conclusions
Our SCORE cluster method can markedly improve the S mansoni prevalence estimate in settings using stool microscopy.
A rare entity of primary hydatid cyst located between the two layers of the intracranial dura in a child: a case report
Authors: Kadri Hassan , Dughly Mazen , Abouharb Raed , Bakleh Sameer , Mackieh Rostom 
Published: December 2023

Abstract
Introduction: Hydatid disease is a parasitic infection caused by the tapeworm Echinococcus granulosus. Intracranial locations are rare and account for less than 3% of all cases. Typically, these cysts are found in the intracerebral spaces. However, this study presents an extremely rare intradural hydatid cyst. To our knowledge no similar case has been previously reported. Case presentation: This study presents the case of an 8-year-old boy presented with a 3-month history of headache and vomiting without any neurological deficit. Full radiological investigations were performed, the brain MRI showed a large cerebral hydatid cyst located within the dura layers between the periosteal and the endosteal layers. Surgery was performed without cyst rupture, confirming the intracerebral intradural location. Conclusion: Early diagnosis and treatment for intracranial hydatid cysts are crucial to prevent complications such as neurological deficits, seizures, and even death. In this case, the intracerebral intradural location of the cyst is extremely rare.
Bilateral superficial temporal vein thrombosis after acute carbon monoxide poisoning and prolonged immobilisation: a case report
Authors: Hamdan Rémy , Bach Benoît , Asdrubal Jacques , Baldassini Anne Laure 
Published: December 2023

Abstract
A prolonged stay on the ground after acute carbon monoxide poisoning (COP) is a high-risk situation for venous thromboembolism (VTE), but unusual-site venous thrombosis is rare in this setting. An 81-year-old woman with no personal or family history of VTE who lied on the ground for several hours following massive COP had painful and oedematous temples, so a Doppler ultrasound was prompted and revealed a bilateral superficial temporal vein (STV) thrombosis. There was no heart failure, trauma, inflammatory disease, infection, or vascular malformation. The thrombosis regressed on fondaparinux 2.5 mg given as a daily subcutaneous injection for 45 days. Our observation emphasizes the need to look not only for arteritis but also for venous thrombosis before any temporal pain. STV thrombosis has been reported four times to date. We report the first case of bilateral STV thrombosis in the setting of massive COP and prolonged immobilisation in an elderly patient.
Concurrent trastuzumab deruxtecan-induced interstitial lung disease and COVID-19 in the treatment of advanced breast cancer
Authors: Yasuda Naoaki , Ikeo Satoshi , Sokai Akihiko , Sakai Yuki , Hayashi Yasuyuki , Kitano Sae , Itoi Naoko , Lee Tecchuu , Iwata Toshiyuki , Nishimura Takashi 
Published: December 2023

Abstract
Patients with cancer are at an increased risk of developing coronavirus disease 2019 (COVID-19) infection. Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) against epidermal growth factor receptor 2 (HER2)-positive cancer, known to cause drug-induced interstitial lung disease (DILD), including drug-induced pneumonitis. A 60-year-old woman with breast cancer developed a fever during treatment with T-DXd and was diagnosed with COVID-19. The fever persisted for approximately 3 weeks, and chest computed tomography showed multiple consolidations with bilateral peripheral predominance. Since the clinical course was atypical for COVID-19 due to the long duration of the fever and the CT pattern was frequently seen in T-DXd-induced ILD, the patient was diagnosed with T-DXd-induced ILD, following which, prednisolone was started, leading to improvement in the symptoms and fading of shadows. Even in patients suspected of COVID-19 pneumonia, physicians should consider the possibility of DILD, particularly in patients undergoing cancer treatment.
Atrial fibrillation caused by Daboia palestinae snakebite: a case report
Authors: Khaldy Marah , Arafat Hasan , Khaldi Yasmina 
Published: December 2023

Abstract

Background
snake envenomation is a serious healthcare issue. Daboia palaestinae is an endemic species to the Middle East that is responsible for the majority of envenomation cases with serious health issue consequences.

Case Presentation
we report a case of a 20-year-old Palestinian man who presented to emergency room following a snake bite. He developed atrial fibrillation which is a rare but serious complication of D. palaestinae snakebite. We reviewed the proper approach and management to such cases.

Conclusion
cardiac arrhythmias are a rare but serious, often fatal, complication of snake envenomation. Early detection and proper management is key to avoid morbidity and mortality.
Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics
Authors: Lu Huifen , Jing Ying , Zhang Chen , Ma Shuai , Zhang Weiqi , Huang Daoyuan , Zhang Bin , Zuo Yuesheng , Qin Yingying , Liu Guang-Hui , Yu Yang , Qu Jing , Wang Si 
Published: December 2023

Abstract
The ovary is indispensable for female reproduction, and its age-dependent functional decline is the primary cause of infertility. However, the molecular basis of ovarian aging in higher vertebrates remains poorly understood. Herein, we apply spatiotemporal transcriptomics to benchmark architecture organization as well as cellular and molecular determinants in young primate ovaries and compare these to aged primate ovaries. From a global view, somatic cells within the non-follicle region undergo more pronounced transcriptional fluctuation relative to those in the follicle region, likely constituting a hostile microenvironment that facilitates ovarian aging. Further, we uncovered that inflammation, the senescent-associated secretory phenotype, senescence, and fibrosis are the likely primary contributors to ovarian aging (PCOA). Of note, we identified spatial co-localization between a PCOA-featured spot and an unappreciated MT2 (Metallothionein 2) highly expressing spot (MT2high) characterized by high levels of inflammation, potentially serving as an aging hotspot in the primate ovary. Moreover, with advanced age, a subpopulation of MT2high accumulates, likely disseminating and amplifying the senescent signal outward. Our study establishes the first primate spatiotemporal transcriptomic atlas, advancing our understanding of mechanistic determinants underpinning primate ovarian aging and unraveling potential biomarkers and therapeutic targets for aging and age-associated human ovarian disorders.