bluuebunny/crossref_metadata_2025_split huggingface dataset:
An One-Year Randomised Controlled Clinical Trial to Assess the Effects of Two Desensitising Agents on Reducing Post-operative Sensitivity After Composite Restorations
Authors: Abd-Elkader Nessrin M. , El-Mahy Waleed A. , Afifi Rania R. 
Published: February 2024

Abstract
Background: Roughly 30% of individuals encounter post-operative sensitivity Subsequent to the placement of resin composite restorations in their posterior teeth, as indicated by various clinical research studies. To alleviate post-operative sensitivity, one approach involves the desensitization of teeth through the occlusion of dentinal tubules using dental desensitizers, aimed at reducing sensitivity following composite restorations.
Methods: A total of 10 patients, all having Class I cavities, were prepared for this study. These patients had a vital pulp and fell within the age range of 18 to 45, maintaining good oral hygiene. Patients with abnormal habits, traumatic occlusion, and gingival disease were excluded from the study. One of three groups was randomly allocated to the participants: Group I received Hurriseal, Group II was treated with Gluma desensitizer, and Group III functioned as the control group. After the dental desensitizer surface treatment and the evaluation of post-operative sensitivity, the teeth were subsequently restored with composite material.
Results: At 1 week, Significant statistical differences among the three groups were observed (p-value = 0.006), with Gluma demonstrating the lowest Visual Analog Scale (VAS) score in comparison to Hurriseal and the Control group.
Nevertheless, no statistically significant differences were identified between the groups at all other timepoints (P value > 0.05). Post-hoc comparisons among the three study groups revealed significant differences between Hurriseal and Gluma, although there were no appreciable variations found between the Gluma and Control groups.
Moreover, significant differences in VAS scores within each group over time were detected (p value= 0.03, 0.001, and 0.01, for Hurriseal, Gluma and control groups, respectively. Statistically significant differences were observed mainly during the comparisons involving the 1-month timepoint in all three groups, suggesting that the most notable changes in pain levels occurred around this period within each group.
Conclusion: Gluma proved to be the most efficient in minimizing postoperative sensitivity after composite restoration, whereas Hurriseal exhibited the least effectiveness in this regard.
Trial registration: The research was formally recorded in the clinicaltrials.gov database.
(#NCT06113874):(02/11/2023).
ClinicalTrials.gov Identifier: NCT06113874
A new method for unmanned aerial vehicle path planning in complex environments
Authors: He Yong , Hou Ticheng , Wang Mingran 
Published: February 2024

Abstract

In response to challenges in unmanned aerial vehicle (UAV) path planning, such as low search efficiency, non-smooth paths, and the inability to adapt to unknown environments, this paper proposes a novel UAV path planning method integrating a dual-layer optimization of A* and the dynamic window approach(DWA). Firstly, neighbor node pruning rules are defined to optimize the node expansion process of the A* algorithm. The heuristic function of the A* algorithm is dynamically adjusted based on obstacle coverage, and key path nodes are extracted using the Bresenham algorithm. Secondly, a deviation sub-function is introduced to enhance local path planning coherence, and an adaptive weighting method for the evaluation function is designed. Lastly, the optimized key nodes are utilized as sub-goals for local path planning, integrating the dynamic window approach to enhance real-time obstacle avoidance and adaptability in unknown environments. Simulation results demonstrate that the proposed method significantly improves the efficiency, smoothness, and obstacle avoidance performance of mobile robot path planning, meeting the requirements of complex planning tasks more effectively.
The Role of Social Media in Monitoring and Predicting Influenza Cases in China: A Time Series Analysis
Authors: Fang Chuangsen , Chen Jialong , Zeng Kewei , Wang Hongjian , Lan Yajia , Li Yanming 
Published: February 2024

Abstract
Background
Influenza remains a global health challenge, necessitating robust surveillance systems for timely intervention. With the prevalence of social media, its potential in health surveillance needs exploration.
Methods
Using outpatient and emergency department data from Beijing Hospital spanning three years (2020 to 2022), and social media data from Chinese platforms, we analyzed trends in influenza-like illness (ILI) cases and related media activity. Descriptive analysis, lead-lag correlation, and causal inference through the PCMCI algorithm were applied. The media’s impact on ILI case trends was quantified using Ordinary Least Squares (OLS) regression.
Results
Weekly analysis showed ILI cases peak during winter, with a consistent increase over the study period. Media index analysis revealed exponential growth and peaks aligning with ILI increases. Lead-lag correlation suggested a one-week lag between media index and ILI cases. PCMCI confirmed a causal relationship, indicating that ILI cases were positively correlated with the media index with a one-week delay. Model comparisons highlighted the improved predictive capability when incorporating media index data.
Conclusion
The study confirmed the utility of social media data as an augmenting factor for influenza surveillance, providing vital insights into outbreak dynamics. The incorporation of media indices in predictive models could enhance early warning systems, offering a promising avenue for public health strategies in China and similar settings.
Establishment of an efficient regeneration system of ‘ZiKui’ tea with hypocotyl as explants
Authors: Jin Jiongyi , Chen Yulu , Cai Ju , Lv Litang , Zeng XiaoFang , Li Jianrong , Asghar Sumeera , Li Yan 
Published: February 2024

Abstract
Zikui (Camellia sinensis cv. Zikui) is a recently discovered cultivar of local purple tea in Guizhou, China and it is a perennial woody plant, mainly propagated by cuttings. It is also a model plant for the study of anthocyanins,but the limited germplasm resources and the limitation of traditional reproduction seriously hinder its application. Here, an efficient regeneration system is established by using hypocotyl as explants for the first time. Different plant growth regulators (PGRs) were evaluated during different regeneration processes including callus and root induction. According to our findings, using the optimal disinfection conditions, the embryo contamination rate was 17.58 %. Additionally, the mortality rate was 9.69 %, while the survival rate was measured as 72.73 %. Moreover, the highest germination rate of 93.64% was observed under MS+2.40 mg/L GA3 medium conditions. The optimal callus induction rate was 95.19 %, while the optimal adventitious bud differentiation rate was 20.74%, Medium with 1.6mg L−1 IBA achieved 68.6% rooting of the adventitious shoots.The survival rate was more than 65% after 6 days growth in the cultivated matrix. In summary, our research aims to establish a regeneration system for Zikui tea plants and design a transformation system for tea plant tissue seedlings. This will enable the transfer of the target gene and ultimately facilitate the cultivation of new tea varieties with unique characteristics.
Using the Health Belief Model to Assess the Impact of Latent Tuberculosis Infection Health Education Video Towards Screening Adoption in Foreign-Born Persons Living in California
Authors: Ojukwu Juliana Uzoma , Stimatze Tamara 
Published: February 2024

Abstract

Background
Tuberculosis (TB) disproportionately affects foreign-born persons from TB-endemic countries. Previous studies demonstrated that educational interventions effectively increased knowledge, perception, and latent tuberculosis infection (LTBI) screening in at-risk people. Given the high prevalence of LTBI and active TB cases and the large proportion of foreign-born individuals with low LTBI awareness residing in California, this study sought to evaluate the impact of video-based LTBI education in this population.
Methods
We evaluated the impact of a 5-minute LTBI educational video on participants using Health Belief Model (HBM) constructs using a pre- and post-test design. We enrolled 84 participants during the study period. Participants identified as (54%) women and 45% men, with 54.48 mean age, and participants identified as Asian (48%), White (37%), Hispanic/Latinx (13%), and Black/African American or Native Hawaiian/Pacific Islander (2%). Participants first completed the pre-survey, which consisted of the HBM LTBI Survey, followed by a demographic survey. Participants then watched the educational intervention video followed by the post-survey, which consisted of the HBM LTBI Survey.
Results
To assess the changes in HBM constructs, we ran six paired-sample t-tests and found a significant increase in perceived susceptibility, t(83) = 8.82, p < .001, perceived severity, t(83) = 2.06, p < .04, perceived benefits, t(83) = 3.33, p < .001 and behavioral intention, t(82) = 3.99, p < .001 with a significant decrease in perceived barriers, t(83) = -3.38, p < .001. To analyze the impact of the HBM constructs on behavioral intentions, we ran a multiple linear regression. Overall, the HBM accounted significantly in variance for behavioral intentions to engage in screening, F(5, 77) = 14.81, p < 0.001; with perceived susceptibility, t(81) = 2.64, p = 0.01, perceived severity t(81) = 2.69, p = 0.009, and self-efficacy t(81) = 3.05, p = 0.003 significantly predicting behavioral intentions for LTBI screening.
Conclusions
This project demonstrates the efficacy of health education videos in promoting awareness and screening for LTBI. The authors recommend using health educational videos in communities and healthcare facilities to create more knowledge, awareness, and engagement in LTBI screening.
In-Vivo Assessment of Movement-Evoked Pain using Digital Technology in Patients with Chronic Back Pain: Implications for treatment personalization
Authors: Frumkin Madelyn , Greenberg Jacob , Zhang Justin , Javeed Saad , Zhang Jingwen , Xu Ziqi , Benedict Braeden , Botterbush Kathleen , Ray Wilson , Lu Chenyang , Rodebaugh Thomas 
Published: February 2024

Abstract
Digital methods are increasingly used to monitor activity and pain, yet few studies combine data streams to assess clinically relevant constructs, such as movement-evoked pain (MEP). In this study of patients with chronic back pain being evaluated for spine surgery, in-vivo assessment of MEP was uncorrelated with pre-surgical pain, interference, or physical function. In support of our hypothesis, however, patients exhibiting greater preoperative MEP demonstrated greater improvement in pain interference one month after spine surgery. Digital technology can be leveraged to improve treatment recommendations for patients with chronic pain.
Prospective Study of Sars-cov2 Associated Coagulopathy and Role of Complement Activation
Authors: Silingardi Mauro , Zappulo Fulvia , Dormi Ada , Pizzini Attilia Maria , Donadei Chiara , Fantoni Chiara , Zaccaroni Stefania , Pizzuti Valeria , Cilloni Nicola , Tantillo Simona , Guidi Antonella , Mancini Rita , Manna Gaetano La , Comai Giorgia 
Published: February 2024

Abstract
Sars-CoV2 associated coagulopathy is a complex entity. Platelets, coagulation factors, fibrinolysis, inflammatory cytokines, immunothrombosis, antiphospholipd antibodies, von Willebrand factor/ADAMTS13 axis, complement system have all been demonstrated to be actively involved in the determination of thrombotic events. Til now retrospective studies have analyzed the activaction of vWF/ADAMTS13 axis and complement involvement. We performed a prospective study with the aim of describing clinical and laboratoristic features of Sars-CoV2 associated coagulopathy and its relationship with complement activation. Biochemical variables, vWF/ADAMTS13 axis, complement factors of the enrolled patients have been analyzed. These variables have been correlated to clinical outcome of the disease. Covid associated coagulopathy is neither a Trombotic Trombocitopenc Purpura (TTP) nor and atypical hemolytic uremic syndrome (aSEU). Nevertheless, imbalance of vWF/Adamts13 axis and complement activation simultaneously occurre and are significantly higher in the severe form of disease.
Degradation of Reactive Red (B-3BF) Dye Wastewater Using UV Irradiation (254/185nm) with Sodium Persulfate in a Pilot UV Device
Authors: Wang Chao , Li Yongqiang , Wan Junmin , Hu Yi , Huang Yi , Qiu Jiangen 
Published: February 2024

Abstract
Two low-pressure ultraviolet (UV) lamps at 185/254 nm with sodium persulfate in a pilot UV device were utilized for the degradation of reactive red (B-3BF) dye wastewater compared with two UV lamps at 185/185 nm and two UV lamps at 254/254 nm. The degradation performances of UV irradiation (254/185 nm) with sodium persulfate under different degradation times, flow rates, initial pH, initial Na2S2O8 concentrations and initial dye concentrations were investigated. The experimental results illustrated that the degradation percentage of B-3BF dye could reduce to 90.42% with the energy consumption of 85.1 kWh/kg and the residual dye concentration of 1.92 mg/L by UV irradiation (254/185 nm) with initial Na2S2O8 concentration of 1.5 mmol/L and initial dye concentration of 20 mg/L. In addition, degradation performance of B-3BF dye wastewater by UV irradiation (254/185 nm) with sodium persulfate was more effective than those of UV irradiation (254/254 nm) and UV irradiation (185/185 nm). Therefore UV irradiation (254/185 nm) with sodium persulfate was promising for the degradation of B-3BF dye wastewater.
Single-cell RNA sequencing has unveiled the contribution of ADSCs in reprogramming metabolism in triple-negative breast cancer
Authors: Zhang Lingling , Xiao Qinyu , Zhang Mili , Liu Xiaojie , Zhou Lijie 
Published: February 2024

Abstract
Background:
Mesenchymal stem cells (MSCs) constitute a significant element of the tumor microenvironment (TME), exerting dynamic influences on various tumors through mechanisms such as chemotaxis, interaction with immune cells. Therefore, MSCs have the ability to dynamically affect various types of tumors. The purpose of this study was to determine the impact of three common MSCs on tumors using single-cell analysis technology.
Methods:
We accessed single-cell sequencing date for mesenchymal stromal stem cells from adipose tissue (ADSCs), human bone marrow (BMSCs), and stem cells from human exfoliated deciduous teeth (SHED) from GEO database (GSE157863). We utilized R packages, including Seurat and Rtsne, for analyzing difference between ADSCs and other MSCs. Subsequently, ADSCs were injected into nude mice bearing mammary tumor cells, and PET-CT was conducted to compare metabolic absorption rates before and after injection. Additionally, bioinformatic analysis and Immunohistochemistry (IHC) were utilized to investigate the function and distribution of CCDC80.
Results:
Bioinformatic analysis revealed that ADSCs differed from BMSCs and SHED, suggesting a potential inhibition of tumor growth through alterations in glycine metabolism. In vivo experiments using a triple-negative breast cancer model demonstrated that the injection of ADSCs inhibited tumor growth. Furthermore, our findings implicated CCDC80 as a potentially pivotal gene influencing metabolism.
Conclusion:
The data derived from this study indicate that ADSCs possess unique capabilities to modulate metabolism and suppress tumor growth. Consequently, ADSCs may emerge as a promising cellular treatment option for triple-negative breast cancer, a subtype currently lacking effective therapeutic interventions.
Association between Systemic Immune-Inflammation Index and stress urinary incontinence in adult women: a population-based study
Authors: Jiang Mei , Yao Xiaodie , Xu Pengfei , Jiang Hua 
Published: February 2024

Abstract

Background
Systemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation may contribute significantly to the aetiology of stress urinary incontinence (SUI), in addition to recognised factors. The aim of this study was to explore the associations between SII and SUI in women.
Methods
Adult participants (≥ 20 years) from the 2007–2018 NHANES were included. The SII level was calculated as the platelet count×neutrophil count/lymphocyte count. Weighted multivariate logistic regression and subgroup analysis were conducted to determine the relationship between SII and SUI in women. The non-linear relationship between SII and SUI risk was evaluated using restricted cubic splines (RCS), and the inflection point was determined by two-piecewise logistic regression.
Results
A total of 10,776 adult women were included, of whom 4407 (40.9%) had SUI. After adjusting for all confounders, a significant positive association between SII and SUI risk was observed (OR: 1.09; 95%CI: 1.01–1.19, P = 0.021). Moreover, when compared with the patients in the lowest SII tertile, those in the highest SII tertile had a 15% increased risk of SUI (OR: 1.15; 95%CI: 1.00-1.31, P = 0.049) after adjustment for all confounders. Subgroup analysis showed that there were consistent relationships between SII level and SUI across most subgroups. A non-linear relationship between log2SII and SUI was observed by RCS analysis. Furthermore, the two-piecewise logistic regression demonstrated that the odds of being SUI increased with the SII level, and this rising trend gradually slowed down after passing the inflection point of 8.64.
Conclusion
Our findings. suggest an association between elevated SII levels and an increased likelihood of SUI in women. Further well-designed prospective studies are needed to substantiate our results
Xiashengella succiniciproducens gen. nov., sp. nov., a succinate-producing bacterium isolated from an anaerobic digestion tank in the family Marinilabiliaceae of the order Bacteroidales
Authors: Huang Hao-Jie , Zhang Xi , Sun Xin-Wei , Chen Biao , Li Xiu-Tong , Zhou Nan , Abdugheni Rashidin , Cheng Qiu-Yin , Zhang Tie-Jun , Liu Yao , Jiang Yong , Deng Ye , Liu Shuang-Jiang , Jiang Cheng-Ying 
Published: February 2024

Abstract
A strictly anaerobic, motile bacterium, designated as strain Ai-910T, was isolated from the sludge of an anaerobic digestion tank in China. Cells were Gram-stain-negative rods. Optimal growth was observed at 38°C (growth range 25–42°C), pH 8.5 (growth range 5.5–10.5), and under a NaCl concentration of 0.06% (w/v) (range 0–2.0%). Major cellular fatty acids were iso-C15 : 0 and anteiso-C15 : 0. The respiratory quinone was MK-7. Using xylose as the growth substrate, succinate was produced as the fermentation product. Phylogenetic analysis based on the 16S rRNA gene sequences indicated that strain Ai-910T formed a distinct phylogenetic lineage that reflects a new genus in the family Marinilabiliaceae, sharing high similarities to Alkaliflexus imshenetskii Z-7010T (92.78%), Alkalitalea saponilacus SC/BZ-SP2T (92.51%), and Geofilum rubicundum JAM-BA0501T (92.36%). Genomic similarity (average nucleotide identity and digital DNA-DNA hybridization) values between strain Ai-910T and its phylogenetic neighbors were below 65.27 and 16.90%, respectively, indicating that strain Ai-910T represented a novel species. The average amino acid identity between strain Ai-910T and other related members of the family Marinilabiliaceae were below 69.41%, supporting that strain Ai-910T was a member of a new genus within the family Marinilabiliaceae. Phylogenetic, genomic, and phenotypic analysis revealed that strain Ai-910T was distinguished from other phylogenetic relatives within the family Marinilabiliaceae. The genome size was 3.10 Mbp, and the DNA G + C content of the isolate was 42.8 mol%. Collectively, differences of the phenotypic and phylogenetic features of strain Ai-910T from its close relatives suggest that strain Ai-910T represented a novel species in a new genus of the family Marinilabiliaceae, for which the name Xiashengella succiniciproducens gen. nov., sp. nov. was proposed. The type strain of Xiashengella succiniciproducens is Ai-910T (= CGMCC 1.17893T = KCTC 25304T).
Enhanced Methods for Evaluating Aquifer Susceptibility: Incorporating Static and Dynamic Vulnerability Assessments.
Authors: Ourarhi Sofia , Barkaoui Alae-Eddine , Zarhloule Yassine 
Published: February 2024

Abstract
This study transforms the concept of the intrinsic vulnerability of aquifers to pollution by integrating static and dynamic elements into the assessment approach. Our innovative methodology simplifies hydrogeological parameters, facilitating the assessment of groundwater aquifer vulnerability while enabling in-depth analysis of future scenarios, including t the impact of human activities and climate change on the hydrological cycle. The results of our analysis reveal that the dynamic vulnerability method (GCITF) and the conventional DRASTIC method generated 12.15% and 9.30% for the high vulnerability zone, respectively. In comparison, the SINTACS method estimated a low percentage of 0.28%. Overlaying the vulnerability maps revealed agreement between the GCITF, DRASTIC and SINTACS methods in the high-vulnerability zones. In particular, the GCITF method showed a more significant extension in zone 2, characterized by an annual extracted volume exceeding 40 Mm3/km2, underlining the importance of considering these sub-factors in dynamic vulnerability assessments. Bivariate statistical analysis, in particular Pearson correlation, revealed a moderate and statistically significant positive association between dynamic vulnerability on the one hand and DRASTIC and SINTACS methods on the other. These results underline the importance of integrating dynamic sub-factors for a more accurate and comprehensive vulnerability assessment, reflecting the complexity of hydrological and anthropogenic interactions influencing aquifer vulnerability.
Application of integrated nursing in minimally invasive rotatory resection for multiple breast tumors.
Authors: Chen Xiaohui , gong yanyan 
Published: February 2024

Abstract
Objective/Purpose:
The objective of this study is to investigate the application of integrated nursing in the minimally invasive rotatory resection for multiple breast tumors.
Method
A multicenter, prospective research strategy was adopted to recruit a specific number of patients who underwent minimally invasive rotatory resection for multiple breast tumors. This approach involved providing systematic and individualized treatment to the patients.
Results
The application of integrated nursing measures has resulted in reducing surgery time, enhancement of surgical results, mitigation of surgical complications, and facilitation of patient recovery. The incidence of postoperative hemorrhage and infection is decreased. Furthermore, research has demonstrated that integrated nursing can enhance patients' psychological well-being and elevate their satisfaction and overall quality of life [1].
Conclusion
The results of this study suggest that integrated nursing has wide-ranging potential in the use of minimally invasive rotatory resection for multiple breast tumors, and it can offer excellent nursing solutions for minimally invasive clinical breast surgery.