bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telenursing on primary family caregivers and children with disabilities: a scoping review
Authors: Nishigaki Kaori , Yamaji Noyuri , Adachi Naho , Kamei Tomoko , Kobayashi Kyoko , Kakazu Shota , Yonekura Yuki 
Published: January 2025

IntroductionDespite the need for continued support for children with disabilities and their families, COVID-19 has made the support difficult. Telenursing can monitor daily life and support from a remote location, continuously and at a low cost. However, there are few practical reports on its use in children with disabilities.ObjectiveThis scoping review aims to summarize the published literature on telenursing for children with disabilities in home care settings.MethodsWe included studies involving children (0–18 years of age) with disabilities and their families and specified telecommunication assessment, monitoring, and intervention such as tele-education, teleconsultation and telementoring involving nurses via information communication technologies. We included studies that used any design written in English or Japanese. A comprehensive search was conducted on March 14, 2021 using six databases: MEDLINE via PubMed, Cumulative Index to Nursing &amp; Allied Health Literature, Cochrane Central Register of Controlled Trials, Embase, PsycINFO, and Ichushi Web. Two or more reviewers individually screened eligible studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram. Data on the characteristics of the included studies, telecommunications technology interventions, and children with disabilities were mapped in tables.ResultsEleven studies, published between 2003 and 2020, met the inclusion criteria. Only one study used the term “telenursing,” while others used “telehealth” and other terms, which involved multidisciplinary support such as physicians and social workers in addition to nurses. Although there were various types of telecommunications technology interventions, they were categorized as consultation, healthcare provision, monitoring, and education. Most studies have examined telecommunication technology interventions by healthcare professionals, including nurses. Five studies focused on children with medical complexities, and two focused on children with neurodevelopmental disabilities, including developmental delays. There is insufficient information on telecommunications technology interventions, especially assessment tools, trigger points, and the status of the target population.ConclusionThis scoping review aimed to map the published literature on telenursing for children with disabilities and their families in home care settings. Available evidence indicates a lack of research focusing on the implementation of telecommunications for children with disabilities and their families. Further research is required to assess the effects of telecommunications technology interventions. Additionally, they should provide information for implementing telecommunication technology safety.Scoping Review RegistrationFigshare (https://doi.org/10.6084/m9.figshare.21747047.v1).
Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline
Authors: Gao Ge , Lin Caipeng , Li Ruibo , Xie Xi , Luo Hai-Bin 
Published: January 2025

ObjectiveOral submucous fibrosis (OSF) is a chronic oral mucosal disease, which exerts a profound impact on patients’ daily life and currently lacks efficacious therapeutic interventions. Epigallocatechin-3-gallate (EGCG), the abundant polyphenol found in green tea, exhibits remarkable anti-fibrotic effects on the skin. However, the research on OSF regarding EGCG is relatively limited.PurposeWe aimed to investigate the potential therapeutic effect of EGCG against OSF using an arecoline (ARE) -induced rat model and primary rat oral fibroblasts.MethodsPrimary rat oral mucosal fibroblasts (ROMF) were isolated and identified. Optimal ARE concentrations were established using the Cell Counting Kit-8. The impact of ARE on extracellular matrix (ECM)-related protein expression was assessed through RT-qPCR and Western blot techniques. Similarly, the effects of EGCG on ARE-induced ECM changes in ROMF were evaluated. The study also established an OSF model in Sprague-Dawley rats, induced by ARE, with pathological changes characterized using HE and Masson’s staining, further assessing the impact of ARE on ECM-related protein expression in rat oral tissues through RT-qPCR and Western blot methods.ResultsEGCG effectively suppressed the ARE-induced ECM components while concurrently improving the OSF pathological process in vitro and in vivo.ConclusionThe results indicate that the natural product EGCG effectively suppressed the increased ECM components induced by ARE and concurrently improved the OSF pathological process, indicating that EGCG could be potentially a novel anti-fibrotic candidate drug for the treatment of OSF.
Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate
Authors: Lazzara Francesca , Conti Federica , Maugeri Grazia , D’Agata Velia , Sotera Ludovica , Bucolo Claudio 
Published: January 2025

IntroductionCorneal damage can happen due to a variety of insults, including environmental factors and iatrogenic issues. For instance, the corneal epithelium is sensitive to oxidative stress caused by reactive oxygen species (ROS) or by ultraviolet B (UVB) radiation. Moreover, the strictly correlated oxidative damage and inflammatory processes impair the corneal reparative wound healing mechanism. Corneal protection after damage remains an unmet medical need that requires urgent management. Sodium hyaluronate is known to protect the cornea against oxidative and inflammatory injury. Additionally, vitamin B12 is a good candidate for counteracting corneal damage, helping preserve visual functions.MethodsThe present study aimed to investigate the potential protective effect of an ophthalmic formulation based on 0.01% vitamin B12% and 0.15% sodium hyaluronate (DROPYAL EVO) compared to other ophthalmic formulations containing sodium hyaluronate and trehalose (TRIMIX and THEALOZ DUO). Two different in vitro models of corneal damage were carried out in corneal epithelial cells exposed to hydrogen peroxide (H2O2, 1 mM) or UVB (20 mJ/cm2). Cell viability, cytotoxicity, ROS production, and mRNA expression of pro-inflammatory cytokines (TNF-α and IL-1β) were assessed by MTT, LDH, 2′,7′–dichlorofluorescein diacetate (DCFDA) assays and Real-time PCR, respectively. Additionally, the ability of ophthalmic formulations to affect the wound healing process in corneal epithelial cells was assessed at different time points by scratch wound healing assay.ResultsThe eye drops containing vitamin B12 were able to significantly counteract oxidative and inflammatory damage in corneal epithelial cells exposed to H2O2 stimulus and UVB radiation, in terms of ROS production and pro-inflammatory cytokines expression. Additionally, the eye drops containing vitamin B12 obtained significantly better outcomes in terms of wound closure at 36 h and 48 h after scratching the corneal epithelial cells, compared to the other two formulations containing trehalose.DiscussionVitamin B12 potentially enhances the protective effect of sodium hyaluronate, accelerating the wound healing process and modulating oxidative stress and inflammation. Vitamin B12, in combination with sodium hyaluronate, could represent a promising approach to managing corneal epithelial damage. Further clinical investigations are needed to confirm this data.
Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials
Authors: Fang Yang , Xiaoling Bai , Huan Li , Yaping Guan , Binying Zhang , Man Wang , Juan Wu , Xinyu Liu 
Published: January 2025

ObjectiveTo explore the impact of various exercise doses on depressive symptoms among hemodialysis patients and offer valuable guidance for the selection of optimal exercise doses in clinical practice settings.MethodsA comprehensive systematic review was conducted across four major databases, namely, PubMed, Embase, Web of Science, and Cochrane Library, covering the period from their inception until August 2024. Exercise interventions were classified based on adherence to American College of Sports Medicine (ACSM) recommendations, dividing studies into groups with high and low/uncertain ACSM adherence. A meta-analysis was performed utilising Review Manager5.4.1 to assess the effects of ACSM adherence on depression in hemodialysis patients.ResultsThis meta-analysis incorporated a total of 19 randomized controlled trials, involving 1,285 patients. The mean age of the patients ranged from 33.2 to 70 years, and the average body mass index (BMI) fluctuated between 23.3 and 28.81 kg/m2. Males accounted for a relatively larger proportion of the participants. Among these trials, 14 were classified as having high ACSM adherence, while 5 were categorized as having low or uncertain adherence. Overall, exercise markedly improved depression in hemodialysis patients (SMD: −0.63, 95% CI: −0.87, −0.39; p &lt; 0.05). The high ACSM adherence group showed greater improvement relative to the low/uncertain adherence group (SMD: −0.66 vs. −0.56). No notable disparities were noted in the effects of exercise duration or patient age on depression outcomes between the subgroups (p = 0.86, p = 0.48).ConclusionExercise interventions that exhibit high adherence to the ACSM guidelines prove to be more efficacious in alleviating depression among hemodialysis patients as compared to those with low or uncertain adherence levels.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero
Surfacing and diving behavior associated with thermal physiology in oceanic habitats of skipjack tuna (Katsuwonus pelamis) in the western north Pacific Ocean
Authors: Aoki Yoshinori , Kitagawa Takashi , Kiyofuji Hidetada 
Published: January 2025

IntroductionThermal physiology is a pivotal biotic factor for the ecophysiology of commercially valuable tuna, influencing not only horizontal but also vertical behaviors. We aimed to examine how the thermal physiology of skipjack tuna (Katsuwonus pelamis, SKJ) can explain the differences in their vertical behavior, focusing on surfacing and diving, among various thermal environments during their northward migration in the western North Pacific.MethodsWe analyzed archival tag data collected during 2012–2015, with individual time series (Fork length: 38–49 cm, N = 38) of swimming depth, water temperature, and peritoneal body temperature during northward migration from subtropical areas to temperate regions around Japan. We quantified surfacing and diving behavior as an index of vertical behavior and estimated the whole-body heat transfer coefficient (λ) during the cooling and warming phases associated with diving using body and water temperature records as indicators of thermal physiology.ResultsIn the southern mixed layer areas, SKJ were widely distributed at a depth layer &lt;200 m, whereas they were restricted to the surface in the strong thermocline areas in the north. The dive duration was significantly shortened with a strong thermal gradient during northward migration. We observed minor to no differences in λ values between the cooling and warming phases in the southern areas, whereas the λ values in temperate areas differed by a factor of 2–3 between the phases.DiscussionOur findings of changes in λ values between the cooling and warming phases represent the first evidence of thermoregulation in SKJ. Surfacing preference behavior and short dive duration in temperate areas may be an avoidance of prolonged exposure to cold temperatures, a behavior commonly exhibited in other tuna. Moreover, we discussed how the changes in vertical behavior driven by thermal physiology can explain spatial heterogeneity in SKJ fishery grounds in the western Pacific Ocean.
Recognition and localization of ratoon rice rolled stubble rows based on monocular vision and model fusion
Authors: Li Yuanrui , Xiao Liping , Liu Zhaopeng , Liu Muhua , Fang Peng , Chen Xiongfei , Yu Jiajia , Lin Jinlong , Cai Jinping 
Published: January 2025

IntroductionRatoon rice, as a high-efficiency rice cultivation mode, is widely applied around the world. Mechanical righting of rolled rice stubble can significantly improve yield in regeneration season, but lack of automation has become an important factor restricting its further promotion.MethodsIn order to realize automatic navigation of the righting machine, a method of fusing an instance segmentation model and a monocular depth prediction model was used to realize monocular localization of the rolled rice stubble rows in this study.ResultsTo achieve monocular depth prediction, a depth estimation model was trained on training set we made, and absolute relative error of trained model on validation set was only 7.2%. To address the problem of degradation of model's performance when migrated to other monocular cameras, based on the law of the input image’s influence on model's output results, two optimization methods of adjusting inputs and outputs were used that decreased the absolute relative error from 91.9% to 8.8%. After that, we carried out model fusion experiments, which showed that CD (chamfer distance) between predicted 3D coordinates of navigation points obtained by fusing the results of the two models and labels was only 0.0990. The CD between predicted point cloud of rolled rice stubble rows and label was only 0.0174.
Implicit and explicit learning strategies and fatigue: an evaluation of throwing task performance
Authors: Banihosseini Reihaneh , Abdoli Behrouz , Kavyani Maryam 
Published: January 2025

IntroductionThis study aimed to determine the effects of implicit (errorless) and explicit (errorful) training strategies on a throwing task under physiological and mental fatigue conditions.MethodsThirty-two participants, equally divided between the explicit and implicit learning groups, participated in a throwing task. The explicit learning group began at a significant distance from the target and gradually moved closer. In contrast, the implicit learning group started close to the target and progressively increased their distance. The initial session referred to as the acquisition phase, comprised 150 throws from five different distances. Subsequent sessions included a retention test and two transfer tests conducted under conditions of both physiological and mental fatigue. Mental fatigue was induced using a 30-minute color-word Stroop task, while physical fatigue was elicited by requiring subjects to maintain 50% of their maximum voluntary isometric contraction (MVC) in elbow extension for a 2-minute duration.ResultsThe results revealed that the implicit learning group exhibited improved performance under fatigue conditions and outperformed the explicit learning group significantly, regardless of the type of fatigue.ConclusionThis results suggests that implicit learning may improve motor performance even under fatigue conditions.
Identification and characteristics of distressed patients with coronary heart disease and insufficiently controlled medical risk factors: baseline findings and sex differences from the multicenter TEACH trial
Authors: Herrmann-Lingen Christoph , Sadlonova Monika , Becker Ingrid , Bersch Kristina , Geiser Franziska , Hellmich Martin , Kindermann Ingrid , Michal Matthias , Nöhre Mariel , Petersmann Astrid , Wachter Rolf , Belnap Birgit Herbeck , Albus Christian 
Published: January 2025

IntroductionMedical risk factors and psychological distress are important targets for secondary prevention of coronary heart disease (CHD). The multicenter randomized controlled TEACH study is the first trial testing a blended collaborative care (BCC) intervention vs. usual care in a cohort of only patients with CHD. The current manuscript analyzes the availability of distressed CHD patients for a BCC intervention trial and the baseline risk profile of the randomized cohort, especially focusing on sex differences.MethodsHospitalized CHD patients with positive HADS and/or PSS-4 screening were rescreened three months later and those still distressed were offered participation in the RCT if they had insufficiently controlled medical risk factors (smoking, physical inactivity, elevated blood pressure, LDL cholesterol, and/or HbA1c). The current manuscript describes the TEACH screening process and presents baseline data of the randomized cohort.ResultsOf 2,785 screened patients, 457 patients with persistent distress and insufficiently controlled risk factors were randomized. Older age and lower distress but not sex independently predicted dropout before randomization. In the randomized cohort (mean age 62.9 ± 9.5 years, 77.4% men), women were older than men (p=0.025), more likely to be retired (52.4% vs. 38.6%; p=0.012) and to live without a partner (48.6% vs. 24.8%, p&lt;0.001). Compared to men, they had lower diastolic blood pressure (p=0.003) but higher rates of physical inactivity (56.0% vs. 41.8%; p=0.012) and positive family history of premature atherosclerotic disease (45.7% vs. 29.8%; p=0.009). They also had a lower rate of previous coronary bypass surgery (21.0% vs. 39.2%, p&lt;0.001). A mental disorder had been diagnosed in 54% of all randomized patients and 42% had previously received mental health treatment, both reported substantially more frequently by women than men (both p&lt;0.001). Satisfaction with care before the trial did not differ by sex but was far lower for psychosocial care than for treatment of heart disease (p&lt;0.001).DiscussionTEACH enrolled a patient sample with persisting distress and a typical risk factor profile. Women differed from men in relevant aspects of their RF profiles and mental health and should receive special attention in future analyses and treatment planning for patients with CHD.Clinical Trial RegistrationGerman Clinical Trials Register, https://drks.de/search/de/trial/DRKS00020824, identifier DRKS00020824.
The impact of perceived caregiver anxiety and stress during childhood on late-life depression: evidence from the China Health and Retirement Longitudinal Study
Authors: Jin Liuyin , Wang Dongdong , Yang Dengxian , Jin Qiong , Cao Mengye , Li Yuanyuan , Yang Jiajie , Xie Guoming , Zhang Wenwu 
Published: January 2025

IntroductionThis study investigates the long-term impact of perceived caregiver anxiety and stress during childhood on late-life depression. Adverse childhood experiences related to caregiver mental health may significantly influence emotional well-being, and this study utilizes data from the China Health and Retirement Longitudinal Study (CHARLS) to explore these associations.MethodsCHARLS data were analyzed for individuals who reported perceived caregiver anxiety and stress. Depression was measured using the CES-10 depression scale. Multivariate logistic regression models examined the relationship between caregiver anxiety and stress frequency and late-life depression, adjusting for confounders like socioeconomic status, health behaviors, and demographics.ResultsChildhood exposure to caregiver anxiety and stress significantly increased the risk of depression in later life (p &lt; 0.05), with stronger effects observed among individuals with female caregivers. The risk escalated with the frequency of caregiver anxiety episodes. After adjusting for covariates, the association for male caregivers weakened, highlighting the potential role of other mediators.DiscussionThe results highlight the critical importance of parental mental health, especially maternal anxiety, in mitigating intergenerational mental health risks. Targeted interventions for caregiver mental health, particularly for female caregivers, are crucial. Longitudinal studies are needed to better establish causality and further investigate these mechanisms.
Short-term and long-term effect of non-pharmacotherapy for adults with ADHD: a systematic review and network meta-analysis
Authors: Yang Xinyue , Zhang Lin , Yu Jing , Wang Meng 
Published: January 2025

BackgroundAttention-Deficit/Hyperactivity Disorder (ADHD) is a lifelong neurodevelopmental condition with a global prevalence of 2.5% to 6.7% among adults. Non-pharmacological interventions have demonstrated effectiveness both as standalone treatments and adjuncts to pharmacotherapy in managing adult ADHD. Nevertheless, the comparative efficacy of these interventions, particularly with respect to diverse ADHD-related outcomes and their long-term impacts, remains insufficiently investigated.ObjectiveThis study aims to evaluate and compare the short-term and long-term effects of various non-pharmacological therapies on core ADHD symptoms (inattention, hyperactivity, and impulsivity) and emotional disorders (depression and anxiety) in adults with ADHD and to rank these therapies accordingly.MethodsA systematic search was conducted for relevant randomized controlled trials (RCTs) in the Web of Science, PubMed, Cochrane Library, and EMBASE databases from inception to Sep 2024. Researchers independently screened and extracted data, and the analysis was performed using R version 4.3.2. Cochrane Risk of Bias tool version 2 (ROB2) and Confidence in Network Meta-Analysis (CINeMA) were used to assess the risk of bias and the certainty of the evidence. Standardized mean differences were estimated using network meta-analyses with random effects.ResultsA total of 37 RCTs involving 2,289 participants and 10 non-pharmacological therapies were included. The risk of bias was classified as low in 24.3%, unclear in 27%, and high in 48.6%, while the CINeMA assessment indicated that confidence in the evidence was “very low” or “low” for most of the remaining treatments. Cognitive behavioral therapy (CBT) showed significantly greater effectiveness than the control group/condition in both the short-term (SMD: -4.43, 95%CI: -5.50 to -3.37) and long-term (SMD: -3.61, 95%CI: -4.66 to -2.56) core symptoms. Additionally, CBT shows both short-term and long-term efficacy for depression (SMD: -4.16, 95%CI: -5.51 to -2.81; SMD: -3.89, 95%CI: -5.95 to -1.83) and anxiety (SMD: -2.12, 95%CI: -3.18 to -1.07; SMD: -7.25, 95%CI: -10.57 to -3.94).ConclusionCBT may be the most effective intervention for adults with ADHD and associated emotional disorders, while Mindfulness-based Cognitive Therapy (MC) is recommended as a preferable option for those without comorbidities. Caution is needed in interpreting our results, and high-quality RCTs are urgently required for more reliable insights.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, identifier CRD42024432912.