bluuebunny/crossref_metadata_2025_split huggingface dataset:
An In Vitro Pharmacognostical Study on Gluconeogenesis and Glucose
Authors: Deepesh Lall  , Neeraj Sharma  , Ritesh Jain  , Pankaj Masih  , Praveen Sharma  
Published: November 2023

Traditional medicine over 60% of the world’s population used for health care name as Mukia maderaspatana (L.) M. Roem. (Cucurbitaceae) (Mukia) is extensively important medicine as an anti-inflammatory plant. It is rich in content of phenolics that exerts various medicinal properties. Mukia extract and its derivatives phenolics such as quercetin and phloroglucinol are investigated for their in vitro anti-inflammatory activity. Materials used was Quercetin, phloroglucinol, and methanol which extract of the dried whole plant (0.55 and 0.6 mg/ml) were studied for the inhibition of gluconeogenesis and glucose Phenolics of Mukia were analyzed by HPLC and UV-spectroscopy. Results obtained were Glucose (1.5 mg/g/h) was synthesized from pyruvate, the synthesis was whole inhibited by insulin (1 U/ml). Quercetin at 0.35 and 0.6 mg/ml caused 60% and 90% inhibition (0.43 mg/g/h and 0.12 mg/g/h glucose). Addition of insulin did not increase inhibition. Phloroglucinol inhibited 100% glucose production with or without insulin. Mukia (0.20 mg/ml) inhibited gluconeogenesis (0.65 mg/g/h) by 40%, and with insulin, inhibition increased to 50% (0.59 mg/g/h). At 0.6 mg/ml, glucose synthesis was stimulated by1.3-fold, but with insulin gets inhibited by 90% (0.12 mg/g/h glucose). Mukia possessed no effect on glucose uptake, in case it potentiated the activity of insulin mediated glucose uptake (153.82 ± 12.30 mg/dl/g/30 min) compared with insulin control (122.41 ± 9.14 mg/dl/g/30 min) (p < 0.02). HPLC analysis revealed the presence of phenolics. Results were concluded scientific rationale for the use of Mukia in medicine as an anti-inflammatory nutraceutical.
Characterization of Anisotropic Geomechanical Properties of Australian Bowen Basin Coals Through Nanoindentation and Upscaling Approaches
Authors: Shi Zhang , Huang Yixiao , Flottman Thomas , Leonardi Christopher , Lu Mingyuan , Chen Zhongwei 
Published: November 2023

Abstract
Coal geomechanical properties are of importance in various applications, including drilling in coal seams, ensuring long-term borehole stability, and predicting the permeability evolution in coal seam gas reservoirs. However, coal is highly cleated and fragile. Obtaining standard drill cores for the laboratory test becomes exceptionally challenging. Also, the anisotropic characterizations of coal mechanical properties are often overlooked despite being essential in understanding directional drilling to increase gas production. In this study, nanoindentation tests were conducted to investigate the anisotropic nanomechanical properties of coal macerals and then the nano-scale data was used to predict the corresponding macroscopic mechanical properties. Overall, 900 indents were made on three types of coal polished surfaces perpendicular to the bedding plane, face, and butt cleats, respectively. The load-displacement curves obtained from the nanoindentation tests were used to calculate the elastic modulus and hardness. We then employed the dilute and Mori-Tanaka homogenization schemes to upscale the nano-scale results. To validate our findings, we compared our predicted values with the results obtained from direct laboratory measurements across different scales. According to the nanoindentation tests, the averaged elastic modulus is 5.89 GPa, 5.75 GPa, and 5.11 GPa, for the directions perpendicular to the bedding (Z), face cleats (Y), and butt cleats (X), respectively. Three coal macerals are identified. The elastic modulus of vitrinite is averaged as 4.55 GPa, 4.75 GPa, and 4.58 GPa for Z, Y, and X directions, respectively. For liptinite and inertinite, their elastic moduli are 4.35 GPa, 4.70 GPa, and 4.24 GPa, as well as 8.76 GPa, 7.80 GPa, and 6.51 GPa, respectively. It was observed that the elastic modulus of inertinite was anisotropic, with the measurement perpendicular to the bedding plane being greater than in the two directions parallel to the bedding plane. There was, however, no significant anisotropy identified for vitrinite and liptinite. This work provides direct measurements of the anisotropic mechanical properties of coal at the nano-scale, and establishes a correlation among the elastic modulus at different scales, especially at the nano-scale. By estimating the coal's mechanical properties from measurements on smaller samples, we provide an alternative approach to understanding the bulk anisotropic features of coals, which benefits various operations, especially directional drilling and permeability.
Mechanical Casing Perforation to Access Reservoir Isolated by Misaligned Casing in Surat Basin CSG Well
Authors: Tooms C. , Rajora A. , Oberhardt M. , Corbett R. , Sharma V. 
Published: November 2023

Abstract
Arrow Energy's current Surat Basin well design uses slotted casing and swellable packers to isolate interburden from productive coal seams to reduce the volume of produced solids entering the artificial lift system. On a few occasions, the casing string with swellable packers has been unable to be landed at the correct depth, resulting in slotted intervals that were misaligned with the coal seams.
In order to establish production from the cased-off coal seams, various scenarios and available technologies were evaluated. Three scenarios were considered: unperforated (leaving the well "as is"), perforated, and the plugging and abandonment of the existing wells and the drilling of new replacement wells. The perforation scenario incorporated the evaluation of different methods to gain access to the reservoir. From the economic analysis, the replacement wells scenario was determined to have the best long-term financial outcome for Arrow Energy, followed by the mechanical casing perforation methods. The results of the economic and technical analyses combined with the risks assessed with the replacement wells scenario indicated that perforation with the mechanical casing perforator tool would be the best solution. The decision was made to trial the mechanical casing perforator tool as a potential solution prior to considering replacement wells. Operational and safety factors resulted in the decision to convey the mechanical casing perforator tool on tubing with the workover rig.
One deviated well with misaligned slotted casing has subsequently been successfully perforated with this methodology, with several lessons learnt from the trial. This well then underwent a standard initial completion with an Electric Submersible Pump (ESP) artificial lift system installed. Start-up was completed on this well and an optimized well status has been reached. When optimized, this well is producing as per the adjusted gas rate forecast, with volumes comparable to other optimized wells on the same multi-well pad.
Costs of the mechanical casing perforation operation were recouped from this well within a week of start-up. The watch points for this well are negative impacts on expected artificial lift system run-life due to potentially higher solids production from the misaligned slotted sections.
Effective Steering of Long Horizontal Appraisal Wells in a Shale Gas Play - Case Study from the Beetaloo Sub-Basin
Authors: Nieto Manuel Felipe Cardozo , Wang Haifeng , Yang Liu , Kalukal Francis , Wang Chao , Zhang Li Li , Hibberson Chris , Van Luu Hoan 
Published: November 2023

Abstract
The Beetaloo Sub-basin is in the Northern Territory and is one of Australia's most promising onshore marine shale gas resources. How to develop these shale gas resources economically is still under investigation by many operators. Recently, Empire Energy Group Limited ("Empire") drilled two horizontal appraisal wells, Carpentaria-2H and Carpentaria-3H, with great success. In this paper, the authors share their experience whilst steering these two wells, including challenges and solutions.
The primary target of the two horizontal wells was the ~70 m thick B Shale of the Velkerri Formation, within the Amungee member of the Roper Group. Geosteering was required to place each well within a high-graded B Shale target window over a long horizontal length. Carpentaria-3H was the more challenging well due to its length coupled with several fault intersections with throw of magnitude proximal to the high-graded target window thickness and structural dips changing across faults.
To tackle these challenges, a rotary steerable system (RSS) with near-bit gamma ray (GR) was used for drilling the long horizontal sections. The target interval of the B shale has elevated uranium content and relatively low potassium and thorium contents. Therefore, a logging-while-drilling (LWD) tool with spectral GR sensors was selected to guide Geosteering. This tool also provided real-time azimuthal GR image around the borehole, which could help the geosteerer determine formation dip and identify faulting. Surface mudlogging provided chromatography and X-ray fluorescence spectroscopy on cuttings provided verification, albeit at a lagged time interval.
Utilizing these fit-for-purpose technologies, the operator first drilled the Carpentaria-2H successfully, placing the horizontal section 100% within the B shale for 1345m MD. One year after, the operator drilled the Carpentaria-3H well. Despite crossing six faults, the 3H well reached the total depth of 4460m achieving a 2632m horizontal section, with 2374m in the Velkerri B-Shale. The C-3H well holds the record of longest horizontal section drilled in the Beetaloo Sub-basin to-date.
Bisbenzimidazole salts and their in silico-in vitro inhibitory abilities on hCAI, hCAII, and AChE enzymes
Authors: Yılmaz Ülkü , Demir Yeliz , Tok Tuğba Taşkın , Gök Yetkin , Aktaş Aydın , Gülçin İlhami 
Published: November 2023

Abstract

New eight bisbenzimidazolium halides were prepared from alkyl halides and 4,4'-bis((benzimidazol-1-yl)methyl)-1,1'-biphenyl. The structures of benzimidazolyum salts were identified thanks to spectroscopic methods. Inhibitory activities of benzimidazole derivatives were measured against hCA I, hCA II and AChE enzymes. It was observed that all benzimidazolium halides have good inhibitory activities against enzymes. They showed highly potent inhibition effect on acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) (Ki values are in the range of 15.66 ± 0.87 to 49.71 ± 10.11 nM, 14.62 ± 1.51 to 70.68 ± 2.67 nM, and 17.38 ± 2.81 to 37.94 ± 10.09nM for AChE, hCA I, and hCA II, respectively). The binding orientation of the synthesized bisbenzimidazole salts was evaluated by molecular docking studies, reflecting the importance of the p-methylbenzyl, m-methylbenzyl, p-nitrophenethyl and 3-(1,3-dioxoisoindolin-2-yl)methyl) groups in protein-ligand interaction. The docking results support the Ki values of the respective compounds in this study. Their interactions with the mentioned enzymes clearly demonstrate the structure-activity relationships against the different targets in three dimensions at atomic level.
Substance Use and Climate-Related Disasters among People Utilizing Syringe Exchange Services in Houston, Texas
Authors: Brinkley-Rubinstein Lauren , O'Toole Lillian , Cullins Zaire , McCauley Erin , Lao Jennifer , Gutierrez Carmen 
Published: November 2023

Abstract

Climate disasters are becoming more common. Certain subsections of the population may be more susceptible to the health harms of escalating weather events. While a large body of work has been developed on the impacts of natural disasters on physical health, less has been explored relevant to substance use. In the current study, we assessed how natural disasters impacted people who use drugs in Houston, Texas, an area that has been repeatedly impacted by many climate-change related events (e.g., floods, hurricanes). We found that there were changes in the macro-market and subsequent seller and drug using patterns. Lack of access to obtaining drugs during storms or disasters occurred often, and participants reported that there were various patterns of use during storms or disasters. Most participants expressed that regardless of the barriers presented by natural disaster, they would usually find a way to obtain substances when they wanted or needed them. Our findings have implications for bolstering the availability of substance use treatment and harm reduction services and developing plans relevant to access in the face of increasing weather disasters.
Development of Nomogram for Predicting Axillary Pathologic Complete Response after Neoadjuvant Therapy in Breast Cancer Patients without Distant Metastasis
Authors: Zhang Jian , Cao Hong-Ming , Wang Gao-Yuan , Nie Chang-Bo , Bai Shou-Min , Ma Shuang 
Published: November 2023

Abstract

(1) Background: For N+ breast cancer patients treated with neoadjuvant therapy, the response to the treatment, especially the probability of axillary pathological complete response (apCR), can guide the choice of subsequent surgical strategy.
(2) Method: 50 N+ breast cancer patients were treated with neoadjuvant therapy, with the response to neoadjuvant therapy guiding subsequent surgical modalities. Logistic regression was used to calculate the coefficients of the significant predictors for axillary pathologic complete response (apCR), and a nomogram was developed based on the logistic model and internally validated.
(3) Results: 4 variables were found to be related to the probability of apCR: pathological grade and molecular subtype (HER2+), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR). The nomogram based predictive cooperating pathological features and hematological test results can be used to predict apCR in N+ breast cancer patients who had received neoadjuvant chemotherapy(NAC). The receiver operating characteristic (ROC) curve for the nomogram model is 0.929 [95% confidence interval (CI): 0.859–0.998], indicating a good discrimination.
(4) Conclusion: A comprehensive predictive model using clinical data is a useful tool to predict the probability of apCR in N+ breast cancer patients receiving NAC.
Feasibility of mobile health app-based home aerobic exercise for physical performance in young healthy adults
Authors: Nam Je Shik , Kim Hyun-Ah , Kwak Tae-Jin , Cho Kang Hee , Jung Il-Young , Moon Chang-Won 
Published: November 2023

Abstract
Background
Compared with fitness facilities or outdoor exercise, home-based exercise programs effectively improve physical performance in an indwelling community. However, a flexible, informal environment may decrease motivation and impair adherence to physical exercise. Mobile devices (e.g., smartphones, tablets, and smartwatch fitness trackers) for aerobic exercise and mobile applications provide real-time monitoring, immediate feedback, and encouragement to increase motivation and promote physical performance. We investigated the feasibility and effects of a mobile app-based home exercise program on body composition, muscular strength, and cardiopulmonary function.
Methods
Between February and May 2023, 20 participants who provided informed consent were randomly allocated to the intervention (mobile application with a tablet) and control groups, and they performed aerobic exercise using a stationary bicycle for at least 150 min per week for 6 weeks (≤ 30-minute exercise session, with 3-minute warm-up and 3-minute cool-down). Karvonen formula-based heartrate defined the weekly increase in exercise intensity. Outcome measures included body-composition parameters, isokinetic knee flexor and extensor strength tests, cardiopulmonary exercise test results, and rate of target HR achievement. Participants were at baseline and after the 6-week intervention.
Results
Unrelated personal events led 2 of 20 participants to drop out. The intervention and control groups had similar baseline characteristics. Compared with the control group, in the post-intervention isokinetic strength test, bilateral knee flexor and extensor power, and time to target HR achievement significantly increased each week in the intervention group.
Conclusions
Home-based exercise to achieve long-term cardiovascular fitness with portable electronic/mobile devices facilitates individualized exercise using real-time feedback to improve motivation and adherence.
Trial registration:
This study has been registered with crs.nih.go.kr (registration number, KCT 0008876) (16/10/2023).
The prognosis of Optical Coherence Tomography-Guided versus Intravascular Ultrasound-Guided Implantation of Drug-Eluting Stents: A Meta-Analysis from Randomized controlled trials
Authors: wang shen , Sun Shuaifeng , Wang Yue , Li Fadong , Wu Xiaofan 
Published: November 2023

Abstract
Objective
Some observational studies and a few meta-analyses have shown a similarity of optical coherence tomography (OCT) in guiding drug-eluting stent (DES) implantation compared with intravascular ultrasound (IVUS). However, a comparison of long-term outcomes between guidance OCT or IVUS from randomized controlled trials (RCTs) is lacking. This study aimed to compare the prognosis of IVUS vs. OCT in guiding stent implantation.
Methods
Randomized controlled trials (RCTs) related to compare long outcomes of IVUS versus OCT in guiding stent implantation from inception to 15 October 2023 were identified using PubMed, Cochrane Library, Medline, Web of Science and EMBASE databases. Two researchers independently screened articles, extracted data, and assessed the quality of each study according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were aggregated for the primary outcome measure using the random-effects model as pooled risk ratio (RR). The primary clinical prognosis including major adverse cardiac events (MACEs), all-cause mortality, all-cause myocardial infarction, all revascularization, and stent thrombosis.
Results
Five RCTs (3,339 patients) were included (OCT guidance = 1,680; IVUS guidance = 1,659). There were similar results for all long-term outcomes between OCT and IVUS-guided DES implantation: major adverse cardiac events (relative risk (RR) = 0.96; 95% confidence interval (CI), 0.68–1.36; P = 0.82), all-cause mortality (RR = 1.00; 95% CI, 0.52–1.91; P = 1.00), all-cause myocardial infarction (RR = 0.81; 95% CI, 0.44–1.49; P = 0.50), all revascularization (RR = 1.02; 95% CI, 0.74–1.42; P = 0.88), and stent thrombosis (RR = 0.44; 95% CI, 0.10–1.97; P = 0.28).
Conclusions
This meta-analysis suggested no significant difference in prognosis between OCT-guided vs. IVUS-guided coronary stent implantation.
Gender differences in high school choices: do math and language skills play a role?
Authors: Contini Dalit , TOmmaso Maria Laura Di , Maccagnan Anna , Mendolia Silvia 
Published: November 2023

Abstract
This paper focuses on the gendered choice of high school in the Italian context, where children are tracked at age 14 and are free to choose the type of school, with no binding teacher recommendation or ability restriction. It is therefore a context in which preferences, however influenced by different factors, are freely expressed, without any institutional constraints imposed on the decision-making process. Previous literature has mainly analysed gendered educational choices by focusing on the field at later stages in life. The transition from lower secondary to upper secondary school is particularly relevant for children who do not go on to university and can help to understand gender segregation in low and middle-level occupations. We analyse the role of school performance in mathematics and Italian (teacher grades and standardized test scores), the position in the class ranking, the comparative advantage in one subject and find that, while school performance hardly explains the gender gap for the children with low educated parents, it explains part of the gender gap observed for children from more advantaged backgrounds.
The Ayounkon project: Visual impairment, eye diseases and unmet eye care needs in the Syrian refugee population and the hosting community in Lebanon
Authors: Abdelmassih Youssef , Makhoul Maxime , Issa Mohammad , Sukkarieh George , Cherfan Daniel , el-Khoury Sylvain 
Published: November 2023

Abstract
Aim:
To report on the distribution of eye diseases, aetiologies of severe visual impairment/blindness (SVI/BL) and unmet eye care needs of the Syrian refugee population and the Lebanese host community.
Methods:
This retrospective study analysed the data of patients that were examined during the Ayounkon project –an eye health care project offering medical and surgical treatment for Syrian refugees and Lebanese host community in the Bekaa Valley in Lebanon. The project took place in three different primary health care centres and involved cooperation between several NGOs and ophthalmologists working on a voluntary basis. Data was analysed for distribution of eye diseases and aetiologies responsible for monocular and binocular SVI/BL.
Results:
A total of 2067 patients were included, 677 were children <18 years. The most frequent pathologies were ocular allergy (10%), and cataract (7.4%). 158 patients (7.6%) were referred for surgery. Glasses were prescribed for 1103 patients (53.4%), of whom 242 (21.9%) were children of school age.
SVI/BL was found in 276 patients (13%). The condition was bilateral in 116 patients (42%). SVI/BL was significantly more frequent in the Syrian population than in the Lebanese (186 patients, 14.8% vs. 86 patients, 11.3%; p=0.04). The main causes for SVI/BL were cataract, keratoconus/corneal decompensation and amblyopia.
Conclusion:
The Syrian refugee population and the Lebanese host community have a high prevalence of ophthalmic pathologies and SVI/BL. Visual impairment is more prevalent in the refugee population. Our findings underscore the importance of targeted interventions and access to eye care services for these populations.
Damage to young pine trees due to growing conditions
Authors: Парамонов С.Г. , Грязькин А.В. , Смирнов А.П. , Семенова Е.И. , Чэн Т. 
Published: November 2023

Представлены результаты единовременного обследования на 8 опытных участках молодняков сосны естественного происхождения и лесных культур на вырубках, под пологом материнского древостоя, а также на бывших сельскохозяйственных землях. Почвенные условия разных объектов объединяет супесчаный минералогический состав. Средний индекс жизнеспособности подроста сосны под пологом древостоев составляет 2,98-3,12, на бывших землях сельскохозяйственного назначения - 4,36-4,43. Под пологом древостоев практически отсутствуют экземпляры подроста сосны без повреждений либо дефектов роста, и здесь в наибольшей степени (до 70%) сосна повреждена биаторелловым раком (Biatorella difformis (Fries.). Наименьшее повреждение снежным шютте (Lopodermium seditiosum Mint.) выявлено у подроста на постагрогенных землях (до 7%). Вместе с тем на постагрогенных землях и вырубках выявлено наибольшее количество поврежденных лосем экземпляров, а также таких пороков, как пасынки и многоветвистость мутовки.
The results of a one-time survey on 8 experimental plots of young pine of natural origin and forest crops on fellings, under the canopy of the mother tree stand, as well as on former agricultural lands are presented. The soil conditions of different objects are united by a sandy loam mineralogical composition. The average index of viability of pine undergrowth under the canopy of stands is 2.98-3.12, on former agricultural lands - 4.36-4.43. Under the canopy of the stands, there are practically no specimens of pine undergrowth without damage or growth defects, and here the pine is most damaged (up to 70%) by biatorella cancer ( Biatorella difformis (Fries.)). The least damage to the snow schütte ( Lopodermium seditiosum Mint.) was detected in undergrowth on postagrogenic lands (up to 7%). At the same time, the largest number of moose-damaged specimens, as well as defects such as stepchildren and multibranch whorl, were found on postagrogenic lands and fellings.