bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic functional connectivity analysis with temporal convolutional network for attention deficit/hyperactivity disorder identification
Authors: Wang Mingliang , Zhu Lingyao , Li Xizhi , Pan Yong , Li Long 
Published: December 2023

IntroductionDynamic functional connectivity (dFC), which can capture the abnormality of brain activity over time in resting-state functional magnetic resonance imaging (rs-fMRI) data, has a natural advantage in revealing the abnormal mechanism of brain activity in patients with Attention Deficit/Hyperactivity Disorder (ADHD). Several deep learning methods have been proposed to learn dynamic changes from rs-fMRI for FC analysis, and achieved superior performance than those using static FC. However, most existing methods only consider dependencies of two adjacent timestamps, which is limited when the change is related to the course of many timestamps.MethodsIn this paper, we propose a novel Temporal Dependence neural Network (TDNet) for FC representation learning and temporal-dependence relationship tracking from rs-fMRI time series for automated ADHD identification. Specifically, we first partition rs-fMRI time series into a sequence of consecutive and non-overlapping segments. For each segment, we design an FC generation module to learn more discriminative representations to construct dynamic FCs. Then, we employ the Temporal Convolutional Network (TCN) to efficiently capture long-range temporal patterns with dilated convolutions, followed by three fully connected layers for disease prediction.ResultsAs the results, we found that considering the dynamic characteristics of rs-fMRI time series data is beneficial to obtain better diagnostic performance. In addition, dynamic FC networks generated in a data-driven manner are more informative than those constructed by Pearson correlation coefficients.DiscussionWe validate the effectiveness of the proposed approach through extensive experiments on the public ADHD-200 database, and the results demonstrate the superiority of the proposed model over state-of-the-art methods in ADHD identification.
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
Authors: Zajac Miroslaw , Lepissier Agathe , Dréano Elise , Chevalier Benoit , Hatton Aurélie , Kelly-Aubert Mairead , Guidone Daniela , Planelles Gabrielle , Edelman Aleksander , Girodon Emmanuelle , Hinzpeter Alexandre , Crambert Gilles , Pranke Iwona , Galietta Luis. J. V. , Sermet-Gaudelus Isabelle 
Published: December 2023

Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate (HCO3−) transport into the Airway Surface Liquid (ASL). We investigated the impact of F508del-CFTR correction on HCO3− secretion by studying transepithelial HCO3− fluxes.Methods: HCO3− secretion was measured by pH-stat technique in primary human respiratory epithelial cells from healthy subjects (WT) and people with CF (pwCF) carrying at least one F508del variant. Its changes after CFTR modulation by the triple combination VX445/661/770 and in the context of TNF-α+IL-17 induced inflammation were correlated to ASL pH and transcriptional levels of CFTR and other HCO3− transporters of airway epithelia such as SLC26A4 (Pendrin), SLC26A9 and NBCe1.Results: CFTR-mediated HCO3− secretion was not detected in F508del primary human respiratory epithelial cells. It was rescued up to ∼ 80% of the WT level by VX-445/661/770. In contrast, TNF-α+IL-17 normalized transepithelial HCO3− transport and increased ASL pH. This was related to an increase in SLC26A4 and CFTR transcript levels. VX-445/661/770 induced an increase in pH only in the context of inflammation. Effects on HCO3− transport were not different between F508del homozygous and F508del compound heterozygous CF airway epithelia.Conclusion: Our studies show that correction of F508del-CFTR HCO3− is not sufficient to buffer acidic ASL and inflammation is a key regulator of HCO3− secretion in CF airways. Prediction of the response to CFTR modulators by theratyping should take into account airway inflammation.
Proteomic exploration reveals a metabolic rerouting due to low oxygen during controlled germination of malting barley (Hordeum vulgare L.)
Authors: O'Lone Clare E. , Juhász Angéla , Nye-Wood Mitchell , Dunn Hugh , Moody David , Ral Jean-Philippe , Colgrave Michelle L. 
Published: December 2023

Barley (Hordeum vulgare L.) is used in malt production for brewing applications. Barley malting involves a process of controlled germination that modifies the grain by activating enzymes to solubilize starch and proteins for brewing. Initially, the grain is submerged in water to raise grain moisture, requiring large volumes of water. Achieving grain modification at reduced moisture levels can contribute to the sustainability of malting practices. This study combined proteomics, bioinformatics, and biochemical phenotypic analysis of two malting barley genotypes with observed differences in water uptake and modification efficiency. We sought to reveal the molecular mechanisms at play during controlled germination and explore the roles of protein groups at 24 h intervals across the first 72 h. Overall, 3,485 protein groups were identified with 793 significant differentially abundant (DAP) within and between genotypes, involved in various biological processes, including protein synthesis, carbohydrate metabolism, and hydrolysis. Functional integration into metabolic pathways, such as glycolysis, pyruvate, starch and sucrose metabolism, revealed a metabolic rerouting due to low oxygen enforced by submergence during controlled germination. This SWATH-MS study provides a comprehensive proteome reference, delivering new insights into the molecular mechanisms underlying the impacts of low oxygen during controlled germination. It is concluded that continued efficient modification of malting barley subjected to submergence is largely due to the capacity to reroute energy to maintain vital processes, particularly protein synthesis.
Validation of the anxiety subscale of the Spanish version of the Edinburgh Postnatal Depression Scale (EPDS-A)
Authors: Gomà Marta , Gordo Leire , Cozodoy Eric , Iriarte Leire , Prims Emma , Ferrer Josep , Sánchez Carmen , Llairó Antònia , Arias-Pujol Eulàlia 
Published: December 2023

IntroductionThere is a need to implement routine perinatal mental health screening in Spain. Therefore, it is necessary to systematise the detection of depressive and anxious symptoms in pregnancy and postpartum using the same instrument. The Edinburgh Postnatal Stress Depression Scale (EPDS) is frequently used as a rapid, effective and cross-culturally validated screening tool for perinatal depression. In several countries, an Anxiety subscale, the EPDS-A, was identified within the EPDS. Although the factorial structure of the EPDS has been investigated in Spanish population, the EPDS-A has not yet been validated. This study aimed to validate the EPDS-A as a measure of perinatal anxiety in Spanish population.Methods161 women were evaluated with the EPDS and the State–Trait Anxiety Inventory (STAI) during pregnancy and postpartum. Confirmatory factor analysis (CFA) was used to confirm the trifactorial structure of the EPDS, comprising the dimensions of Depression, Anhedonia and Anxiety. Likewise, the invariance of the trifactorial model between pregnancy and postpartum was tested. Finally, the correlations between the EPDS-A and the STAI subscales (State Anxiety and Trait Anxiety) were calculated.ResultsThe Exploratory factor analysis (EFA) driven three-factor structure of the EPDS, consisting of an Anhedonia factor (Items 1, 2, and 10), an Anxiety factor (Items 3, 4, 5, and 6) and a Depression factor (Items 7, 8, and 9), was the best measurement model for the current data compared to the alternative model tested [χ2 = 34.592, df = 32, p = 0.34; χ2/df = 1.08; RMSEA = 0.023, 90% Confidence Interval [CI] [0.000, 0.064], CFI = 0.996, GFI = 0.960]. The model’s invariance between pregnant and postpartum women was confirmed. The existence of an Anxiety subscale within the EPDS was also confirmed. The scores obtained with the EPDS-A correlated moderately with scores on both subscales of the STAI during pregnancy and after delivery. Using the STAI as a criterion and prioritising the instrument’s sensitivity, a cut-off point of 4 points was established for the EPDS-A.ConclusionOur results confirm the trifactorial structure of the EPDS in Spanish population. The Anxiety subscale was validated for routine perinatal mental health screening.
Renal failure following insulin purging in atypical anorexia nervosa and type 1 diabetes mellitus
Authors: Rometsch Caroline , Guthoff Martina , Zipfel Stephan , Stengel Andreas 
Published: December 2023

ObjectiveAnorexia nervosa (AN) and atypical anorexia nervosa (AAN) are severe and complex eating disorders that can be prevalent among individuals with type 1 diabetes mellitus (T1DM). Insulin purging, characterized by the intentional underuse / omission of insulin to control weight, is under-recognized in medicine and is a purging strategy of patients with AN or AAN and comorbid T1DM. Often, this can lead to renal failure, necessitating a (pancreas-) kidney transplantation. This article presents a comprehensive overview of the interplay between AN/AAN and T1DM and summarizes the evidence in literature.MethodsA narrative review is presented on basis of a detailed case study of a 32-year-old female with end-stage renal failure seeking (pancreas-) kidney transplantation displaying etiology, diagnosis, comorbidities, complications, and treatment of AN and AAN with emphasis on those patients with T1DM.ResultsInsulin purging in patients with AN/AAN and coexisting T1DM can exacerbate T1DM complications, including accelerating the onset of end-stage renal failure. A multidisciplinary approach including nutrition treatment and psychotherapeutic techniques was considered necessary for treatment, focusing on psychosomatic in-patient care before and after organ transplantation.ConclusionInsulin purging in patients with AAN and T1DM poses severe health risks, including accelerated renal complications. For those considering transplantation, insulin purging has explicitly to be diagnosed and a holistic treatment addressing both the renal condition and psychosomatic symptoms/disorders is crucial for successful post-transplant outcomes.
Comparison of healing effectiveness of different debridement approaches for diabetic foot ulcers: a network meta-analysis of randomized controlled trials
Authors: Ning Peng , Liu Yupu , Kang Jun , Cao Hongyi , Zhang Jiaxing 
Published: December 2023

ObjectivesThe choice of the debridement method is very important for the healing of diabetic foot ulcers (DFUs), but the relative effectiveness of different debridement methods in the healing of DFUs remains unclear. This study conducted a network meta-analysis of the relative healing effectiveness of different debridement methods in patients with DFUs.MethodsWe performed a literature search in PubMed, Embase, and Cochrane Library from database inception up to 30 June 2023 for screening randomized controlled trials on the healing effectiveness of debridement in DFUs. Outcome measures included ulcer healing rate and ulcer area reduction rate. The Cochrane Risk Bias Tool, version 2.0, was used to assess the risk of bias in the included trials. R software was used for performing statistical analysis and GraphPad Prism was used for image plotting.ResultsA total of 19 randomized controlled trials were included, and 900 patients with DFUs were assessed in this analysis. The proteolytic fraction from the latex of Vasconcellea cundinamarcensis (P1G10) in enzymatic debridement showed the best ulcer healing rate (SURCA = 0.919) when compared with the standard of care (SOC) group, with a mean difference (MD) and 95% confidence interval (CI) of 1.40 (0.57, 2.36). Kiwifruit extract demonstrated the best effect on the ulcer area reduction rate (SURCA = 0.931), when compared with that in the SOC group, with an MD and 95% CI of 0.47 (0.27, 0.66).ConclusionEnzymatic debridement was superior to other debridement methods in terms of ulcer healing rate and ulcer area reduction rate in patients with DFUs. However, as the quality of the included trials is low, enzymatic debridement can be used as a candidate debridement method in addition to sharp-based debridement in clinical practice.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023441715.
Prevalence and trends in mono- and co-infection of COVID-19, influenza A/B, and respiratory syncytial virus, January 2018–June 2023
Authors: Lee Min Kyung , Alfego David , Dale Suzanne E. 
Published: December 2023

ObjectivesThis study aimed to determine the impact of the COVID-19 pandemic on the overall prevalence and co-infection rates for COVID-19, influenza A/B, and respiratory syncytial virus in a large national population.MethodsWe conducted a retrospective review of 1,318,118 multi-component nucleic acid amplification tests for COVID-19, influenza A/B, and RSV performed at Labcorp® sites from January 2018 to June 2023, comparing positivity rates and co-infection rates by age, sex, and seasonality.ResultsIn 2021–2023, 1,232 (0.10%) tested positive for COVID-19 and influenza A/B, 366 (0.03%) tested positive for COVID-19 and RSV, 874 (0.07%) tested for influenza A/B and RSV, and 13 (0.001%) tested positive for COVID-19, influenza A/B, and RSV. RSV positivity rates were particularly higher in Q2 and Q3 of 2021 and in Q3 of 2022. Higher influenza A positivity proportions were found in Q4 of 2021 and again in Q2 and Q4 of 2022. Influenza B positivity had been minimal since the start of the pandemic, with a slight increase observed in Q2 of 2023.ConclusionOur findings highlight the need for adaptability in preparation for upper respiratory infection occurrences throughout the year as we adjust to the COVID-19 pandemic due to the observed changes in the seasonality of influenza and RSV. Our results highlight low co-infection rates and suggest heightened concerns for co-infections during peaks of COVID-19, influenza, and RSV, which may perhaps be reduced.
Intelligent selection of healthcare supply chain mode – an applied research based on artificial intelligence
Authors: Long Ping , Lu Lin , Chen Qianlan , Chen Yifan , Li Chaoling , Luo Xiaochun 
Published: December 2023

IntroductionDue to the inefficiency and high cost of the current healthcare supply chain mode, in order to adapt to the great changes in the global economy and public health, it is urgent to choose an effective mode for sustainable development of healthcare supply chain. The aim of this paper is to use artificial intelligence systems to make intelligent decisions for healthcare supply chain mode selection.MethodsFirstly, according to the economic benefits, social benefits and environmental benefits of healthcare supply chain, this paper identifies different healthcare supply chain modes in combination with artificial intelligence technology. Secondly, this paper presents the intelligent choice optimization method of healthcare supply chain mode based on deep reinforcement learning algorithm. Finally, the effect of artificial intelligence in healthcare supply chain mode selection is verified by simulation experiment.Results and DiscussionThe experimental results show that healthcare supply chain mode selected by artificial intelligence is basically consistent with the target mode, while healthcare supply chain mode selected by the basic selection method, BP neural network method and big data method is different from the target mode, which indicates that AI has more advantages in the selection of medical supply chain mode. Therefore, we recommend the application of artificial intelligence to healthcare supply chain management. This study not only makes up for the ineffective problems of existing methods, but also makes up for the gaps in the application of AI technology in the field of healthcare supply chain. The scientific value of this paper is that the proposed framework and the artificial intelligence algorithm enrich the relevant theories of healthcare supply chain research and provide methodological guidance for intelligent decision-making of healthcare supply chain. At the same time, for medical enterprises, this research provides a new practical guideline for the application of artificial intelligence in the sustainable development and modern management of healthcare supply chain.
Measurement of the Optical Path Difference Caused by Steering Mirror Using an Equal-Arm Heterodyne Interferometer
Authors: Zhu Weizhou , Guo Yue , Jin Qiyi , Wang Xue , Qian Xingguang , Xie Yong , Meng Lingqiang , Jia Jianjun 
Published: December 2023

In space gravitational wave detection, the inter-satellite link-building process requires a type of steering mirror to achieve point-ahead angle pointing. To verify that the background noise does not drown out the gravitational wave signal, this paper designed a laser heterodyne interferometer specifically designed to measure the optical path difference of the steering mirror. Theoretically, the impact of angle and position jitter is analyzed, which is called tilt-to-length (TTL) coupling. This interferometer is based on the design concept of equal-arm length. In a vacuum (10−3 Pa), vibration isolation (up to 1 Hz), and temperature-controlled (approximately 10 mK) experimental environment, the accuracy is increased by about four orders of magnitude through a common-mode suppression approach and can reach 390 pm/Hz when the frequency is between 1 mHz and 1 HZ. By analogy, the optical path difference caused by the steering mirror reaches 5 pm/Hz in the 1 mHz to 1 Hz frequency band. The proposed TTL noise model is subsequently verified.
Interdisciplinary approach to the diagnosis of dentofacial deformities and speech disorders in preschoolers
Authors: Danilova M. A. , Goncharova-Tverskaya O. N. , Zalazaeva E. A. , Prokoshev P. A. 
Published: December 2023

Relevance. Maxillofacial deformities and speech disorders are common types of oral pathology detected in children under seven years. Comprehensive rehabilitation of patients with a combination of these forms of pathology is a difficult task since there is no situational analysis of their prevalence; motivated specialists work in different institutions (education, healthcare) and have different guidelines for the treatment (correction) of existing diseases (disorders), which complicates planning and administering treatment, and predicting results.Material and methods. To identify the nature of the relationship between various forms of orthodontic and speech disorders in children, we conducted a comprehensive clinical dental examination of 80 children aged 4-6 years in a preschool educational institution, where children with speech disorders receive speech therapy assistance.Results. Maxillofacial deformities appeared to be in 56.25% of children with some speech sound disorder. Children with identified speech sound disorders combined with dentofacial deformities showed not only skeletal but also soft tissue defects: shifted midline (86.67 ± 0.10%), distal occlusion (42.22 ± 0.30%), deep overbite (46.68%), as well as tongue and upper lip ties in 51.10% and 22.20% of cases, respectively. On examination, 44.45% of patients demonstrated clinical signs of mouth breathing, 32.5% – reverse swallowing, and 53.33% – inefficient chewing.Conclusion. Analysis of the results of a comprehensive speech pathology assessment and dental examination allowed us to conclude that there is a need to rethink the methodology of diagnosis, prevention and treatment of combined speech and dental disorders due to the high frequency of their comorbidity in preschool children.
“A formação de grupos de professores de diferentes áreas para o desenvolvimento de projetos com interação dialógica será o futuro da extensão”. Entrevista com o Prof. Dr. Eduardo Galhardo (UNESP/Assis)
Authors: Carvalho Roberta Cajaseiras de 
Published: December 2023

Comunicar a produção científica e extensionista da UNESP Assis tem sido umas das missões do Prof. Eduardo Galhardo na última década, através da coordenação do projeto TV UNESP Assis, acessível à comunidade externa através de programas transmitidos em tv aberta e fechada. Sua íntima e profícua relação com a extensão universitária também o levou a chefiar a edição da Revista Ciência em Extensão, que divulga as produções extensionistas brasileiras desde 2004. Em entrevista realizada à Revista Caminho Aberto, o professor nos apresenta as peculiaridades da produção extensionista da UNESP, e os desafios para viabilizar a curricularização da extensão universitária em todos os cursos até 2010. A interação dos graduandos e docentes com a sociedade em busca de gerar transformação social, e a criação de projetos em redes foram alguns dos assuntos abordados pelo professor durante esse bate-papo, repleto de conhecimento e esperança no importante papel que a extensão possui para interferir positivamente na realidade brasileira.DOI: http://dx.doi.org/10.35700/ca.2020.ano7n12.p12-15.2829
Ensino e extensão no Bacharelado de Ciência e Tecnologia da UFERSA: análise da exposição de fotografias sobre temas transversais e percepção dos estudantes
Authors: Oliveira Alan Martins de , Martins Jacqueline Cunha de Vasconcelos , Ferreira Kananda Suélen Leite , Damasceno Filho Francisco Estevão 
Published: December 2023

A ação de extensão “exposição de fotografias sobre temas transversais” foi realizada como parte do projeto desenvolvido no Programa de Ações de Apoio à Melhoria do Ensino de Graduação, na UFERSA, Câmpus Mossoró-RN. Esse artigo tem por objetivo descrever o diagnóstico realizado com os estudantes e refletir sobre a exposição dos temas por meio de fotografias. O projeto de ensino e a ação de extensão contribuíram com a inclusão dos temas transversais na formação dos estudantes e na comunidade.DOI: http://dx.doi.org/10.35700/ca.2020.ano7n12.p16-25.2595
Leitura e escrita em espaços coletivos: primeiros passos da ação
Authors: Cortez Mariana , Ospina Edwin Alexander Sanabria 
Published: December 2023

O projeto de extensão “Vivendo livros latino-americanos na tríplice fronteira: descobrir e resgatar identidades” trabalha nas bibliotecas das escolas públicas da região da tríplice fronteira (Puerto Iguazú, Foz do Iguaçu e Ciudad del Este) com o propósito de contribuir para a reflexão de professores e alunos no que concerne às práticas de leitura e escrita que se desenvolvem nesses espaços coletivos, à formação de professores e à situação do espaço físico e acervo necessário para a promoção da leitura e escrita literária, de forma a integrá-la à dinâmica escolar como ambiente essencial aos processos de aprendizagem. Enfatizamos que nos interessa especialmente contribuir para a consolidação de acervos referentes à literatura latino-americana, bem como propor práticas pedagógicas que valorizem a leitura e a escrita literária como um processo de descoberta e resgate das identidades da fronteira.DOI: http://dx.doi.org/10.35700/ca.2020.ano7n12.p26-34.2614
Gravidez, parto e puerpério: conversando com gestantes e familiares
Authors: Casarin Sidnéia Tessmer , Cagliari Raquel , Rosado Caroline Ramos , Machado Cristina do Amaral 
Published: December 2023

Objetiva relatar a execução de um curso para gestantes e familiares realizado em uma unidade de saúde no município de Pelotas/RS. O curso foi desenvolvido em cinco encontros que trataram das modificações corporais e desenvolvimento fetal, parto, trabalho de parto e direitos da gestantes, amamentação e cuidados com o recém-nascido e puerpério. As atividades foram avaliadas como relevantes pelos participantes, além de propiciar aos discentes a interação dos conhecimentos adquiridos na academia.DOI: http://dx.doi.org/10.35700/ca.2020.ano7n12.p62-67.2617