bluuebunny/crossref_metadata_2025_split huggingface dataset:
Housing Status, Cancer Care, and Associated Outcomes Among US Veterans
Authors: Decker Hannah C. , Graham Laura A. , Titan Ashley , Kanzaria Hemal K. , Hawn Mary T. , Kushel Margot , Wick Elizabeth 
Published: December 2023

ImportanceCancer is a leading cause of death among older people experiencing homelessness. However, the association of housing status with cancer outcomes is not well described.ObjectiveTo characterize the diagnosis, treatment, surgical outcomes, and mortality by housing status of patients who receive care from the US Department of Veterans Affairs (VA) health system for colorectal, breast, or lung cancer.Design, Setting, and ParticipantsThis retrospective cohort study identified all US veterans diagnosed with lung, colorectal, or breast cancer who received VA care between October 1, 2011, and September 30, 2020. Data analysis was performed from February 13 to May 9, 2023.ExposuresVeterans were classified as experiencing homelessness if they had any indicators of homelessness in outpatient visits, clinic reminders, diagnosis codes, or the Homeless Operations Management Evaluation System in the 12 months preceding diagnosis, with no subsequent evidence of stable housing.Main Outcomes and MeasuresThe major outcomes, by cancer type, were as follows: (1) treatment course (eg, stage at diagnosis, time to treatment initiation), (2) surgical outcomes (eg, length of stay, major complications), (3) overall survival by cancer type, and (4) hazard ratios for overall survival in a model adjusted for age at diagnosis, sex, stage at diagnosis, race, ethnicity, marital status, facility location, and comorbidities.ResultsThis study included 109 485 veterans, with a mean (SD) age of 68.5 (9.7) years. Men comprised 92% of the cohort. In terms of race and ethnicity, 18% of veterans were Black, 4% were Hispanic, and 79% were White. A total of 68% of participants had lung cancer, 26% had colorectal cancer, and 6% had breast cancer. There were 5356 veterans (5%) experiencing homelessness, and these individuals more commonly presented with stage IV colorectal cancer than veterans with housing (22% vs 19%; P = .02). Patients experiencing homelessness had longer postoperative lengths of stay for all cancer types, but no differences in other treatment or surgical outcomes were observed. These patients also demonstrated higher rates of all-cause mortality 3 months after diagnosis for lung and colorectal cancers, with adjusted hazard ratios of 1.1 (95% CI, 1.1-1.2) and 1.3 (95% CI, 1.2-1.4) (both P &amp;lt; .001), respectively.Conclusions and RelevanceIn this large retrospective study of US veterans with cancer, homelessness was associated with later stages at diagnosis for colorectal cancer. Differences in lung and colorectal cancer survival between patients with housing and those experiencing homelessness were present but smaller than observed in other settings. These findings suggest that there may be important systems in the VA that could inform policy to improve oncologic outcomes for patients experiencing homelessness.
First Domino in the Structural Collapse of Perovskite CsPbI3 and Its Stabilizing Strategies
Authors: Guo Zhendong , Fu Jiayuan , Chen Gaoyuan , Liu Feng , Yu Chao , Lu Ruifeng , Yin Wan‐Jian 
Published: December 2023

AbstractThe retention of the photoactive phase is vital for inorganic CsPbI3 perovskite solar cells; however, the atomic‐level knowledge is currently elusive, leading to trial‐and‐error methods in experiments. In this study, proves that the kinetic process dominates the lifetime of CsPbI3, while the energetic difference, which is conventionally thought to be a dominant factor, only plays a secondary role. The defect—iodine vacancy (VI) can significantly lower the kinetic barriers and act as the seed of structural collapse in the corner‐sharing octahedral structure. Inspired by this, the success of B‐ and X‐site doping as well as strain engineering for stabilizing CsPbI3 arising from the suppression of VI are explained. Through comprehensively investigating thirty‐two and fifteen kinds of passivators substituting on the Pb and I site, respectively, on reducing the VI concentration and inhibiting its diffusion, proposed that the trivalent lanthanide cations, especially La3+ on Pb site, and highly electronegative anions with a small size on I site are proper doping candidates to enhance the stability of perovskite CsPbI3. The results provide a universal picture and guidance for engineering all‐inorganic perovskite CsPbI3 for elevated stability with the focus on inhibiting iodine vacancies.
Engineered Cell‐Laden Armor Unit‐Mimicking Bioceramic Granules for Bone Regeneration
Authors: Wu Yuangang , Xing Zhengyi , Zhao Rui , Chen Siyu , Shang Tieliang , Liu Zhanhong , Geng Mengyu , Ma Jun , Zhu Xiangdong , Zeng Yi , Yang Xiao , Shen Bin , Zhang Xingdong 
Published: December 2023

AbstractBioceramic granules have been used as fillers for the repair of various bone defects, but structural instability leads to susceptibility to displacement or dislodgement in practice. Armor unit is a concrete block placed along the breakwater to resist waves and protect the dike. Inspired by this, an armor unit‐mimicking (AU) bioceramic granule by three‐dimentional (3D) printing is developed, and combine it with adipose‐derived stem cells (ADSCs) overexpressing fibroblast growth factor 23 (FGF23) to construct tissue‐engineered bone. In vitro results show that AU granules and FGF23 transfection synergistically promote osteogenic differentiation of ADSCs. For the repair of beagle femoral metaphyseal defects, the implanted AU granules are stacked and interlocked to form an impact‐resistant porous scaffold. With the assistance of ADSCsFGF23, AU granules exhibit enhanced new bone formation and host bone maintenance. Taken together, these findings demonstrate the potential of 3D‐printed AU granules in combination with FGF23‐overexpressing ADSCs as a novel bone void filler for ease of handling and enhanced bone regeneration.
The “Pudding Effect” to Promote Solar‐Driving Water Purification
Authors: Mingot Júlia , Lanzalaco Sonia , Àgueda Alba , Torras Juan , Armelin Elaine 
Published: December 2023

AbstractThe use of solar energy (natural) and synthetic solar absorber hydrogels (SAHs) for purification of brackish water represent a challenge. Here in, this work reports the unexpected effect achieved for water desalination when combining a small content of conducting polymer (CP), poly(3,4‐ethylenedioxythiophene) (PEDOT), doped with poly(styrene sodium sulfonate) (PSS), with a well‐known thermosensitive polymer, poly(N‐isopropylacrylamide) (PNIPAAm). Less than 10% of CP is enough to achieve an evaporation rate of 3.45 ± 0.36 KMH, compared to the gel without the ionic polymer (1.75 ± 0.08 KMH). Furthermore, this work proves that the presence of alginate polysaccharide (ALG), which is a conventional reinforcement molecule applied to reach a stable entangled scaffold, is greatly favorable in compositions with 5 wt% of doped CP, reaching even a higher evaporation rate (4.50 ± 0.30 KMH). These results seem to be caused by a shrinkage effect named by the authors: “pudding effect.” The highly stable hydrogel double network demonstrated to have enough mechanical integrity for the hand manipulation of the gel in successive solar water evaporation cycles. Thus, the new system (with or without ALG) is a promising SAH candidate for self‐portable water desalinators for domestic uses. The hydrogel preparation can be performed in one‐pot reactor to customer up‐scale size necessities.
Injectable Plasma‐Treated Alginate Hydrogel for Oxidative Stress Delivery to Induce Immunogenic Cell Death in Osteosarcoma
Authors: Živanić Milica , Espona‐Noguera Albert , Verswyvel Hanne , Smits Evelien , Bogaerts Annemie , Lin Abraham , Canal Cristina 
Published: December 2023

AbstractCold atmospheric plasma (CAP) is a source of cell‐damaging oxidant molecules that may be used as low‐cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non‐invasive treatment of internal tumors with cold plasma via injection. However, liquids are easily diluted with body fluids which impedes high and localized delivery of oxidants to the target. As an alternative, plasma‐treated hydrogels (PTH) emerge as vehicles for the precise delivery of oxidants. This study reports an optimal protocol for the preparation of injectable alginate PTH that ensures the preservation of plasma‐generated oxidants. The generation, storage, and release of oxidants from the PTH are assessed. The efficacy of the alginate PTH in cancer treatment is demonstrated in the context of cancer cell cytotoxicity and immunogenicity–release of danger signals and phagocytosis by immature dendritic cells, up to now unexplored for PTH. These are shown in osteosarcoma, a hard‐to‐treat cancer. The study aims to consolidate PTH as a novel cold plasma treatment modality for non‐invasive or postoperative tumor treatment. The results offer a rationale for further exploration of alginate‐based PTHs as a versatile platform in biomedical engineering.
Bioengineered Tubular Biliary Organoids
Authors: Elci Bilge Sen , Nikolaev Mikhail , Rezakhani Saba , Lutolf Matthias P. 
Published: December 2023

AbstractLiver organoids have emerged as promising in vitro models for toxicology, drug discovery, and disease modeling. However, conventional 3D epithelial organoid culture systems suffer from significant drawbacks, including limited culture duration, a nonphysiological 3D cystic anatomy with an inaccessible apical surface, and lack of in vivo‐like cellular organization. To address these limitations, herein a hydrogel‐based organoid‐on‐a‐chip model for the development functional tubular biliary organoids is reported. The resulting constructs demonstrate long‐term stability for a minimum duration of 45 d, while retaining their biliary organoid identity and exhibiting key cholangiocyte characteristics including transport activities, formation of primary cilia, and protective glycocalyx. Additionally, tubular organoids are susceptible to physical and chemical injury, which cannot be applied in such resolution to classical organoids. To enhance tissue‐level complexity, in vitro formation of a perfusable branching network is induced using a predetermined geometry that faithfully mimics the intricate structure of the intrahepatic biliary tree. Finally, cellular complexity is augmented through co‐culturing with vascular endothelial cells and fibroblasts. The models described in this study offer valuable opportunities for investigating biliary morphogenesis and elucidating associated pathophysiological mechanisms.
NNMT/1‐MNA Promote Cell‐Cycle Progression of Breast Cancer by Targeting UBC12/Cullin‐1‐Mediated Degradation of P27 Proteins
Authors: Ma Yilei , Huang Xucheng , Wang Yanzhong , Lei Yinjiao , Yu Jinwei , Yu Shaobo , Gao Yuzhen , Yang Jun , Zhao Feng , Yu Haitao , Zeng Jin , Chu Yadong , Yang Min , Li Guoli , Xie Xinyou , Zhang Jun 
Published: December 2023

AbstractCell cycle dysregulation is a defining feature of breast cancer. Here, 1‐methyl‐nicotinamide (1‐MNA), metabolite of nicotinamide N‐methyltransferase(NNMT) is identified, as a novel driver of cell‐cycle progression in breast cancer. NNMT, highly expressed in breast cancer tissues, positively correlates with tumor grade, TNM stage, Ki‐67 index, and tumor size. Ablation of NNMT expression dramatically suppresses cell proliferation and causes cell‐cycle arrest in G0/G1 phase. This phenomenon predominantly stems from the targeted action of 1‐MNA, resulting in a specific down‐regulation of p27 protein expression. Mechanistically, 1‐MNA expedites the degradation of p27 proteins by enhancing cullin‐1 neddylation, crucial for the activation of Cullin‐1‐RING E3 ubiquitin ligase(CRL1)—an E3 ubiquitin ligase targeting p27 proteins. NNMT/1‐MNA specifically up‐regulates the expression of UBC12, an E2 NEDD8‐conjugating enzyme required for cullin‐1 neddylation. 1‐MNA showes high binding affinity to UBC12, extending the half‐life of UBC12 proteins via preventing their localization to lysosome for degradation. Therefore, 1‐MNA is a bioactive metabolite that promotes breast cancer progression by reinforcing neddylation pathway‐mediated p27 degradation. The study unveils the link between NNMT enzymatic activity with cell‐cycle progression, indicating that 1‐MNA may be involved in the remodeling of tumor microenvironment.
Fluid Ferroelectric Filaments
Authors: Máthé Marcell T. , Perera Kelum , Buka Ágnes , Salamon Péter , Jákli Antal 
Published: December 2023

AbstractFreestanding slender fluid filaments of room‐temperature ferroelectric nematic liquid crystals are described. They are stabilized either by internal electric fields of bound charges formed due to polarization splay or by external voltage applied between suspending wires. The phenomenon is similar to those observed in dielectric fluids, such as deionized water, except that in ferroelectric nematic materials the voltages required are three orders of magnitudes smaller and the aspect ratio is much higher. The observed ferroelectric fluid threads are not only unique and novel but also offer measurements of basic physical quantities, such as the ferroelectric polarization and viscosity. Ferroelectric nematic fluid threads may have practical applications in nano‐fluidic micron‐size logic devices, switches, and relays.
A Methylazanediyl Bisacetamide Derivative Sensitizes Staphylococcus aureus Persisters to a Combination of Gentamicin And Daptomycin
Authors: Heo Hee Young , Zou Guijin , Baek Seongeun , Kim Jae‐Seok , Mylonakis Eleftherios , Ausubel Frederick M. , Gao Huajian , Kim Wooseong 
Published: December 2023

AbstractInfections caused by Staphylococcus aureus, notably methicillin‐resistant S. aureus (MRSA), pose treatment challenges due to its ability to tolerate antibiotics and develop antibiotic resistance. The former, a mechanism independent of genetic changes, allows bacteria to withstand antibiotics by altering metabolic processes. Here, a potent methylazanediyl bisacetamide derivative, MB6, is described, which selectively targets MRSA membranes over mammalian membranes without observable resistance development. Although MB6 is effective against growing MRSA cells, its antimicrobial activity against MRSA persisters is limited. Nevertheless, MB6 significantly potentiates the bactericidal activity of gentamicin against MRSA persisters by facilitating gentamicin uptake. In addition, MB6 in combination with daptomycin exhibits enhanced anti‐persister activity through mutual reinforcement of their membrane‐disrupting activities. Crucially, the “triple” combination of MB6, gentamicin, and daptomycin exhibits a marked enhancement in the killing of MRSA persisters compared to individual components or any double combinations. These findings underscore the potential of MB6 to function as a potent and selective membrane‐active antimicrobial adjuvant to enhance the efficacy of existing antibiotics against persister cells. The molecular mechanisms of MB6 elucidated in this study provide valuable insights for designing anti‐persister adjuvants and for developing new antimicrobial combination strategies to overcome the current limitations of antibiotic treatments.
Development of a novel PPTA/cellulose composite insulation paper with low dielectric constant and improved mechanical properties by BTCA crosslinking
Authors: Mo Yang , Hu Gang , Gao Yuanyuan , Zhang Mao , Liao Ruijin 
Published: December 2023

AbstractThis study investigates the effect of 1,2,3,4‐butane tetracarboxylic acid (BTCA) crosslinking treatment on the electrical properties of poly‐p‐phenylene terephthalate (PPTA)/cellulose insulation paper to prepare a novel composite insulation paper with low dielectric constant and good electrical performance. Three‐layer PPTA/cellulose composite paper crosslinked by BTCA under various conditions, composite paper without crosslinking, directly mixed composite paper, and conventional Kraft paper are prepared. The morphology and surface chemical composition of the paper samples are characterized. Dielectric, mechanical, and thermal properties are investigated. Results show that the BTCA concentration of 0.2 mol L−1 with a 180°C curing temperature is the relatively superior crosslinking condition to prepare a novel composite with low dielectric constant and good comprehensive performance. The dielectric constant and loss of the novel composite paper decrease to 3.21 and 0.392 at 50 Hz. The tensile strength of the BTCA crosslinked three‐layer PPTA/cellulose composite paper (thickness: 130 μm) has reached 10.01 kN m−1, increased by 41.6% than the directly mixed composite paper. The novel BTCA crosslinked composite paper also shows improved thermal stability. The BTCA crosslinking proves to be a promising method to improve the dielectric properties and electrical performance of the PPTA/cellulose composite paper.
Paradigmatic conformity blinds us from opportunity: a rejoinder
Authors: Janiszewski Chris , Laran Juliano 
Published: December 2023

AbstractThere is value in blending behaviorism and cognitivism when investigating consumer behavior. Traditionally, the blend has consisted of a serving of cognitivism with a dash of behaviorism. Behaviorism might inform the focus (e.g., predictive learning) or assumptions about the process (e.g., Bayesian updating), but cognitivism comprises the theoretical foundation. We propose there is value in an alternative blend—a serving of behaviorism with a dash of cognitivism. Cognitivism might inform the selection of stimulus cues (e.g., predictive learning) or assumptions about the process (e.g., association strengths), but behaviorism informs the manipulations of causal factors (e.g., stimulus properties, reward schedules, and learning history). Embracing alternative approaches to blending behaviorism and cognitivism creates opportunities for novel insights into consumer behavior.
Bestimmung und Validierung von Materialparametern für die nichtlineare Modellierung von Beton
Authors: Birkner Dennis , Freybe Nele , Marx Steffen 
Published: December 2023

AbstractIn diesem Beitrag wird gezeigt, dass mit den in der weit verbreiteten Software ANSYS Mechanical standardmäßig implementierten Materialmodellen das Tragverhalten von Beton‐ und Stahlbetonbalken zutreffend simuliert werden kann. Die notwendigen Materialparameter lassen sich mithilfe von Laborversuchen ermitteln. An Betonzylindern sind dies Versuche zur Bestimmung der Druck‐ und Spaltzugfestigkeit sowie des Elastizitätsmoduls. Die Bruchenergie wird an gekerbten Balken ermittelt. Dieser Versuch wird anschließend mit dem Drucker‐Prager‐Modell in Kombination mit Rankine‐Fließflächen und exponentieller Entfestigung nachgebildet. Bei Verwendung der experimentell ermittelten Materialparameter stimmt das berechnete Last‐Verformungs‐Verhalten gut mit den Messkurven überein. Eine Vergleichsrechnung mit normativ vorgeschlagenen Parametern überschätzt die Bruchenergie und somit die Traglast der Prüfkörper. Anschließend wird das numerische Modell anhand von Stahlbetonbalkenversuchen validiert. Das Modell mit den experimentell ermittelten Materialparamatern kann das Tragverhalten der Prüfkörper gut abbilden, jedoch wird auch deutlich, dass eine geeignete Modellierung des Verbundverhaltens wichtig ist. In diesem Fall wird das Tragverhalten der Balken mit Federelementen zwischen Beton‐ und Bewehrungsknoten am besten beschrieben. Ferner wird gezeigt, dass die Verwendung von reduziert bzw. voll integrierten Elementen einen großen Einfluss auf das simulierte Entfestigungsverhalten von Beton haben kann.
Design of experiment‐oriented development and validation of novel bioanalytical reverse phase high performance liquid chromatography method of palbociclib in rat plasma and tissues, and its application in pharmacokinetic studies
Authors: Rajana Naveen , Pooja Yeruva Sri , Bhavana Valamla , Chary Padakanti Sandeep , Dukka Komalatha , Deshmukh Rajeshwari , Mehra Neelesh Kumar 
Published: December 2023

AbstractThe current research involved the development and validation of an easy, cost‐effective, and sensitive bioanalytical reverse‐phase high‐performance liquid chromatography method for the assessment of palbociclib (PAL) in rat plasma and kidney, liver, spleen and heart. A response surface methodology‐based Box–Behnken design was used to optimize critical chromatographic conditions such as buffer pH, organic phase concentration and flow rate to attain good sensitivity, tailing factor and retention time. The conditions were: pH of buffer, 4.5; organic phase concentration, 40%; Shimpac column with 1.0 ml/min flow rate. The responses were: tailing factor, 1.29 ± 0.03, sensitivity, 366,593 ± 8,592; and retention time, 4.5 ± 0.05 min. The samples were extracted by a protein precipitation method, and absolute recoveries were in the range of 88.99–95.08%. The linearity of the developed method was validated over the range 100–2,000 ng/ml (r2 ≥ 0.994) in all tested matrices. The developed bioanalytical method showed greater accuracy (0.98 and 4.01%) and precision (<4.88%). The method was optimized for the sensitive analysis of the PAL in rat plasma, and the kidney, liver, spleen and heart were effectively applied to pharmacokinetic studies.
An empirical analysis of corporate sustainability bonds
Authors: Mathew Sudha , Sivaprasad Sheeja 
Published: December 2023

AbstractThis study examines the performance of worldwide corporate sustainability bonds issued from 2014 to 2020. Unlike traditional bonds, the proceeds of sustainability bonds are utilised for financing projects to bring about environmental and socio‐economic benefits. We analyse the short‐term market reaction to announcements of sustainability and traditional bond issuance and document that the stock market reaction to an announcement of sustainability bonds is stronger than that for traditional bonds. We also find that multiple issuers of sustainability bonds achieve a more favourable market reaction than single issuers. Finally, we examine if environmental, social and governance (ESG) scores can positively and significantly impact the corporate performance of firms through the lens of sustainability bond issuances. We find that ESG scores are the primary performance drivers for firms, and the effect is more pronounced for firms that issue sustainability bonds. Overall, the results suggest that issuers of sustainability bonds show their commitment towards environmental and societal goals and thus benefit from favourable stock market reactions.
Collaboration among circular start‐ups and incumbents in the circular economy context
Authors: Tuladhar Alisha , Iatridis Konstantinos , Dimov Dimo 
Published: December 2023

AbstractCircular economy (CE) has emerged as a sustainable alternative to the current “take, make, waste” linear approach. Although prior studies have highlighted the salience of collaborative efforts between start‐ups and incumbents, little is known about the mechanisms behind collaboration in a CE context. This study enhances our understanding of the topic by drawing on six cases of circular start‐ups (CSUs) operating in the United Kingdom's business‐to‐business market and investigating the mechanisms by which start‐ups collaborate with incumbents. Using the Context, Intervention, Mechanism, Outcome framework, the paper's findings demonstrate that CE does not necessitate high‐risk and expensive changes and show that CSUs can collaborate with incumbents in low‐risk ways by outsourcing and developing service contracts.