bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional evaluation of steal by unligated first intercostal branch before transcatheter embolization in recurrent angina after a LIMA‐LAD graft
Authors: Morocutti Giorgio , Gasparini Daniele , Spedicato Leonardo , Gelsomino Sandro , Paparella Gaetano , Bernardi Guglielmo , Fioretti Paolo 
Published: October 2002

AbstractUnligated side branches of the left internal mammary artery (LIMA) have been indicated as a cause of coronary steal resulting in postoperative angina. Although a number of studies have reported successful embolization of the side branches to relieve angina, this phenomenon is still controversial and it has been either emphasized or rejected in studies that attempted to obtain hemodynamic evidence of the steal using angiographic and intravascular Doppler techniques. In this case study, we tried to reproduce physiological decrease in the muscular and coronary beds as it could occur during activity. Our results, using an intracoronary Doppler wire with adenosine combined with forced ventilation, showed that a trial occlusion of the LIMA side branch with a balloon technique can demonstrate whether the flow through the LIMA would increase after embolization of the side branch. Cathet Cardiovasc Intervent 2002;56:373–376. © 2002 Wiley‐Liss, Inc.
Iodide‐induced sialadenitis complicating coronary angiography
Authors: Ben‐Ami Ronen , Zeltser David , Herz Itzhak , Mardi Tamar 
Published: October 2002

AbstractSialadenitis is an uncommon complication of intravenous administration of iodinated contrast medium. We present two cases of iodide‐induced sialadenitis following coronary angiography. Clinical features and clues to differentiation from suppurative sialadenitis are discussed. The mechanism for aseptic iodide‐induced sialadenitis remains unclear, but prognosis with conservative treatment is apparently good. Sialadenitis may recur with subsequent administration of contrast medium. Cathet Cardiovasc Intervent 2002;57:50–53. © 2002 Wiley‐Liss, Inc.
Predicting melting temperature (Tm) of oligoribonucleotide duplex by neural network
Authors: Ma Lixin , Cheng Changmei , Miyajima Hiromi , Zhao Yufen , Herdewijn Piet 
Published: October 2002

AbstractA straightforward method to predict melting temperatures of RNA duplexes by artificial neural network is developed. The network consists of three layers in which there are 12 input layer units (10 nearest neighbors and two terminals), two hidden layer units and one output layer unit (melting temperature). It is found that the predicted data for the test set agree with the measured data quite well (AD = 3.7 K, R2 = 0.9359, SEP = 4.17 for NN1; AD = 2.85 K, R2 = 0.8843, SEP = 3.43 for NN2). This method omits the determination of thermodynamic parameters and therefore is a simpler way to predict the stability of RNA duplex. Copyright © 2002 John Wiley & Sons, Ltd.
Sorting of raw materials with focus on multiple end‐product properties
Authors: Berget Ingunn , Næs Tormod 
Published: October 2002

AbstractIn industry, variability in raw material quality often leads to unstable end‐product quality. By sorting the raw materials into homogeneous groups, stability and quality of the end‐product can be improved. The optimal splitting and the corresponding optimal process settings in each category can be found by fuzzy clustering. In the single‐response case the distance between groups and objects is defined as the predicted response's distance to the target. When there are multiple responses, the distance between an object and a category can be based either on a quadratic loss function that weights the different responses or on desirability functions. Another approach is to put restrictions on the less important responses when optimizing the process variables. These three methods are discussed and illustrated by an example. The constrained approach was not suited for the example treated, while the other two approaches gave similar solutions to the optimization problem. Copyright © 2002 John Wiley & Sons, Ltd.
Evaluation of chemotherapy response in pediatric bone sarcomas by [F‐18]‐fluorodeoxy‐D‐glucose positron emission tomography
Authors: Hawkins Douglas S. , Rajendran Joseph G. , Conrad Ernest U. , Bruckner James D. , Eary Janet F. 
Published: October 2002

AbstractBACKGROUNDResponse to neoadjuvant chemotherapy is a significant prognostic factor for osteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT). Conventional radiographic imaging does not discriminate between responding and nonresponding osseous tumors. [F‐18]‐fluorodeoxy‐D‐glucose (FDG) positron emission tomography (PET) is a noninvasive imaging modality that accurately predicts histopathologic response in patients with various malignancies. To describe the FDG PET imaging characteristics and to determine the correlation between FDG PET imaging and chemotherapy response in children with bone sarcomas, we reviewed our single institution experience.METHODSThirty‐three pediatric patients with OS or ESFT with osseous primary sites were evaluated by FDG PET. All patients received standard neoadjuvant chemotherapy. FDG PET standard uptake values before (SUV1) and after (SUV2) chemotherapy were analyzed and correlated with chemotherapy response assessed by histopathology in surgically excised tumors. Twenty‐six patients had SUV1, SUV2, and surgical excision.RESULTSAlthough the mean SUV1 in children with OS or ESFT were similar (8.2. vs. 5.3, P = 0.13), mean SUV2 for OS patients was greater than the values for ESFT patients (3.3 vs. 1.5, P = 0.01). All ESFT patients and 28% of OS patients had a favorable histologic response to chemotherapy (≥ 90% necrosis). Combining ESFT and OS patients, both SUV2 and the ratio of SUV2 to SUV1 (SUV2:SUV1) were correlated with histologic response (P = 0.01 for both comparisons).CONCLUSIONFDG PET evaluation of pediatric bone sarcomas demonstrated significant alteration in response to neoadjuvant chemotherapy. SUV2 and SUV2:SUV1 correlated with histopathologic assessment of response and potentially could be used as a noninvasive surrogate to predict response in patients. Cancer 2002;94:3277–84. © 2002 American Cancer Society.DOI 10.1002/cncr.10599
High‐density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation
Authors: Chan Kok‐Lung , Man‐Fong Lee Joyce , Guan Xin‐Yuan , Fan Sheung‐Tat , Oi‐Lin Ng Irene 
Published: October 2002

AbstractBACKGROUNDAllelic deletions are frequent genetic alterations in patients with hepatocellular carcinoma (HCC).METHODSTo evaluate the allelic losses on chromosome 8p in HCC patients and define their clinicopathologic significance, we performed high‐density allelotyping on 8p in 60 patients with HCC and analyzed the clinicopathologic correlation.RESULTSUsing 24 microsatellite markers, allelic losses on 8p were frequent. Loss of heterozygosity (LOH) at one or more loci was observed in 34 (57%) HCC patients. When the allelic losses were compared between groups categorized by clinicopathologic variables, significant correlation was found between tumors with interstitial losses and larger tumor size (> 5 cm; P = 0.026). In addition, allelic loss at D8S298 at 8p22 was associated closely with venous permeation, tumor microsatellite formation, and larger tumor size (P = 0.019, 0.024, and 0.007, respectively). LOH at locus D8S1721 at 8p23.1 was seen more frequently in nonencapsulated tumors (P = 0.007) and LOH at D8S1771 at 8p21.3 was associated with a larger tumor size and poorer cellular differentiation (P = 0.018 and 0.049, respectively).CONCLUSIONSAllelic losses on 8p are frequent in HCC patients. Association of allelic losses at specific loci on 8p with a more aggressive tumor behavior suggests that loss/inactivation of putative tumor suppressor gene(s) located at these regions may confer a tumor growth advantage and contribute to the progression of HCC. Cancer 2002;94:3179–85. © 2002 American Cancer Society.DOI 10.1002/cncr.10612
Usefulness of tumor pressure as a prognostic factor in cases of hepatocellular carcinoma where the diameter of the tumor is 3 cm or less
Authors: Ueki Toshiharu , Sakaguchi Seigo , Miyajima Yasushi , Hatono Nagafusa , Tohara Keiji , Nakabayashi Shoichi , Yao Tsuneyoshi , Kokawa Hiroshi , Hirano Motoi , Okumura Makoto 
Published: October 2002

AbstractBACKGROUNDThe current study was designed to determine the usefulness of pretreatment tumor pressure as a new prognostic factor in patients with small hepatocellular carcinoma (HCC; 3 cm or smaller in diameter).METHODSThe study included 39 patients with small HCC in whom tumor pressure was determined. They underwent percutaneous ethanol (with Lipiodol) injection therapy (Lp‐PEI) or transcatheter arterial embolization (TAE) of the hepatic artery. Tumor pressure was determined percutaneously under ultrasonographic guidance. The factors analyzed were age, gender, mean blood pressure, the presence/absence of antibody to hepatitis C virus (anti‐HCV), alcohol abuse, Child's classification, the presence/absence of esophagogastric varices, serum α‐fetoprotein (AFP) level, tumor size, number of tumors, degree of tumor differentiation, the presence/absence of tumor capsule, tumor pressure, and the method of treatment. Multivariate analysis using Cox proportional hazards model was conducted on the factors that may have affected prognosis (P< 0.25) according to the univariate analysis using a proportional hazards model.RESULTSThe rates of local and distant recurrence were higher (P< 0.01,P< 0.01, respectively) and the survival rate was lower (P= 0.03) in patients with high tumor pressure than in those with low tumor pressure. Multivariate analysis revealed that tumor pressure (P< 0.01), AFP level (P= 0.01), and age (P= 0.01) were significant predictive factors associated with local recurrence. Tumor pressure (P< 0.01) and AFP level (P< 0.01) were both significantly associated with distant recurrence. The only significant predictive factor associated with survival rate was tumor pressure (P< 0.04).CONCLUSIONSThe current study revealed that tumor pressure was associated significantly with survival rates after Lp‐PEI or TAE in patients with small HCC. There were also significant predictive factors associated with local recurrence, these being tumor pressure, AFP level, and age, and with distant recurrence, namely, tumor pressure and AFP level. Tumor pressure measured before the initial treatment of patients with small HCC may be a useful new prognostic factor. Cancer 2002;95:596–604. © 2002 American Cancer Society.DOI 10.1002/cncr.10690
Detection method and breast carcinoma histology
Authors: Newcomer Laura M. , Newcomb Polly A. , Trentham‐Dietz Amy , Storer Barry E. , Yasui Yutaka , Daling Janet R. , Potter John D. 
Published: October 2002

AbstractBACKGROUNDThe association between method of detection and breast carcinoma histopathology has not been assessed adequately in a population‐based setting.METHODSAmong women who were included in a population‐based, case‐control study of breast cancer, patients who were newly diagnosed with invasive breast carcinoma were identified from Wisconsin's statewide tumor registry. Only women age ≥ 50 years were analyzed, because screening by mammography was not recommended before age 50 years at the time of the study. The breast tumors among these women (n = 2341 tumors) included the following histopathologies: lobular carcinoma (n = 206 tumors); ductal carcinoma, not otherwise specified (n = 1920 tumors); papillary carcinoma (n = 15 tumors); medullary carcinoma (n = 36 tumors); mucinous adenocarcinoma (n = 56 tumors); tubular adenocarcinoma (n = 41 tumors); invasive comedocarcinoma (n = 24 tumors); scirrhous adenocarcinoma (n = 15 tumors); and mixed ductal/lobular carcinoma (n = 28 tumors).RESULTSOverall, women reported that 41% of tumors were detected by mammography, 48% of tumors were self detected, and 11% of tumors were detected by clinical breast examination (CBE). Detection by mammography was significantly more likely for women who had tubular carcinoma (83%; P < 0.001) and invasive comedocarcinoma (67%; P = 0.23) compared with women who had ductal carcinoma (40%). Mammography was significantly less likely to detect medullary carcinoma (17%) than ductal carcinoma (40%; P = 0.01). Lobular carcinoma was the only histopathology that, compared with ductal carcinoma, was detected significantly more often by CBE than by self detection. Mammography detected lobular carcinoma (42%) as frequently as ductal carcinoma (40%). However, the use of postmenopausal hormones may have modified these detection patterns: Among current users, mammography discovered a greater percentage of ductal carcinomas (51%) and fewer lobular carcinomas (36%) than nonusers.CONCLUSIONSAmong women age ≥ 50 years, breast cancer detection by mammography, self detection, and CBE varied according to tumor histopathology. Cancer 2002;95:470–7. © 2002 American Cancer Society.DOI 10.1002/cncr.10695
Optimal use of sentinel lymph node biopsy versus axillary lymph node dissection in patients with breast carcinoma
Authors: Wong Sandra L. , Abell Troy D. , Chao Celia , Edwards Michael J. , McMasters Kelly M. 
Published: October 2002

AbstractBACKGROUNDThere are no data available from randomized controlled trials that compare the efficacy of sentinel lymph node (SLN) biopsy with Level I/II axillary lymph node dissection (ALND) in patients with breast carcinoma. We performed a formal decision analysis to determine whether SLN biopsy is appropriate, compared with ALND, for patients with T1, T2, and T3 tumors and to quantify the relative value of these two procedures in the management of patients with breast carcinoma.METHODSAll clinically relevant outcomes were modeled for both SLN biopsy and ALND. The probabilities of complications and outcomes were derived using data from the University of Louisville Breast Cancer Sentinel Lymph Node Study and from extensive review of previous studies. Utilities were assigned by the authors, incorporating values from the literature whenever possible.RESULTSThe expected utility of SLN biopsy was higher than the expected utility for ALND for T1 and T2 tumors that were 4.0 cm or smaller. There was no clear preference for either procedure with tumors that were larger than 4.0 cm. The T1 and T2 results were robust to sensitivity analysis.CONCLUSIONSThe results of this decision analysis suggest that SLN biopsy is preferred over ALND for patients with breast tumors that are 4.0 cm or smaller. Patients should be aware of the potential for false‐negative results in SLN biopsy, but this risk is outweighed by the decreased morbidity associated with the procedure itself. Cancer 2002;95:478–87. © 2002 American Cancer Society.DOI 10.1002/cncr.10696
Childhood and adolescent thyroid carcinoma
Authors: Grigsby Perry W. , Gal‐or Anat , Michalski Jeff M. , Doherty Gerard M. 
Published: October 2002

AbstractOBJECTIVESThis analysis was performed to evaluate the influence of clinical and treatment factors on local tumor control, control of distant metastasis, survival, and complications in children and adolescents with thyroid carcinoma.METHODSThe records of 56 children and adolescents with papillary and follicular carcinoma of the thyroid were reviewed. They ranged in age from 4 to 20 years. There were 43 females and 13 males. At diagnosis, 15 (27%) patients had disease confined to the thyroid, 34 (60%) had additional lymph node metastasis to the neck or upper mediastinum, and 7 (13%) also had lung metastasis. Treatment consisted of a total thyroidectomy in 48 patients, a subtotal thyroidectomy in 4 patients, and a lobectomy in 4 patients. All 56 patients received postoperative thyroid hormone suppressive therapy.131I was administered to 82% (46 of 56) of patients after their initial surgery.RESULTSThe overall survival rate was 98% with a follow‐up of 0.6–30.7 years (with a median follow‐up of 11.0 years). The one death that occurred in this patient population was the result of a congenital heart defect and was unrelated to thyroid carcinoma. The 10‐year progression‐free survival rate was 61%. Nineteen patients (34%) experienced a recurrence of their thyroid carcinoma. The time to first recurrence of disease ranged from 8 months to 14.8 years (mean, 5.3 years). None of those with disease confined to the thyroid developed recurrent disease. The recurrence rate was 50% (17 of 34) in patients with lymph node metastasis and 29% (2 of 7) in patients with lung metastasis (P= 0.02). Tumor characteristics were evaluated for time to first recurrence utilizing the logistic likelihood ratio test to predict disease recurrence. Thyroid capsule invasion (P= 0.02), soft tissue invasion (P= 0.03), positive margins (P= 0.006), and tumor location at diagnosis (thyroid only vs. thyroid and lymph nodes vs. thyroid, lymph nodes, and lung metastasis,P= 0.02) were significant for developing recurrent disease. Patients younger than 15 years old at diagnosis were more likely to have more extensive tumor at diagnosis than patients who were 15 years and older (thyroid only vs. thyroid and lymph nodes vs. thyroid, lymph nodes, and lung metastasis,P= 0.02).CONCLUSIONCarcinoma of the thyroid in children and adolescents has little risk of mortality but a high risk of recurrence. Younger patients present with a more advanced stage of disease and are more likely to have disease recurrence. Total thyroidectomy and lymph node dissection, followed by postoperative131I therapy, thyroid hormone replacement (suppressive) administration, and diligent surveillance are warranted. Cancer 2002;95:724–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10725
Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C‐viral chronic liver diseases
Authors: Yamagamim Hiroaki , Moriyama Mitsuhiko , Matsumura Hiroshi , Aoki Hiroshi , Shimizu Toshihiro , Saito Takahide , Kaneko Miki , Shioda Atsuo , Tanaka Naohide , Arakawa Yasuyuki 
Published: October 2002

AbstractBACKGROUNDNumerous reports have examined the relationship between hepatocyte growth factor (HGF) and either the facilitation or suppression of the occurrence of hepatocellular carcinoma (HCC).METHODSIn this study, we measured serum HGF concentrations of blood samples and conducted prospective studies to examine the long‐term outcome of C‐viral chronic hepatitis (CH) and cirrhosis in patients. The subjects examined in this study include 99 patients with C‐viral CH, cirrhosis, and HCC. The serum HGF level was measured in blood samples within 48 hours of collection using enzyme‐linked immunosorbent assay kits.RESULTSThe serum concentrations of HGF were significantly higher in patients with HCC than in patients with CH or cirrhosis. The detection rate of HGF and its mean serum level were significantly higher in patients with a low platelet count than in patients with a high platelet count. All of the patients with serum HGF concentrations of more than 0.6 ng/mL had HCC, irrespective of the levels of α‐fetoprotein, vitamin K absence, or antagonist‐II in the blood. Serum HGF concentrations increased concomitantly with increases in areas occupied by HCC. The cumulative incidence of occurrence of HCC was significantly higher in patients with high HGF concentrations than in patients with low HGF concentrations. Multivariate analysis revealed that the elevation in serum HGF level is the most important risk factor for the occurrence of HCC.CONCLUSIONSThe serum level of HGF represents the degree of the carcinogenic state in the liver of patients with C‐viral CH and cirrhosis. Therefore, the determination of serum HGF concentrations may be useful as a third tumor marker of HCC in detection as well as follow‐up therapy. Cancer 2002;95:824–34. © 2002 American Cancer Society.DOI 10.1002/cncr.10732
Recurrent micropapillary serous ovarian carcinoma
Authors: Bristow Robert E. , Gossett Dana R. , Shook David R. , Zahurak Mariana L. , Tomacruz Rafael S. , Armstrong Deborah K. , Montz Fredrick. J. 
Published: October 2002

AbstractBACKGROUNDThe objectives of the current study were to: 1) characterize the clinical outcome of patients with recurrent micropapillary serous ovarian carcinoma (MPSC) and 2) evaluate the survival impact of secondary cytoreductive surgery and other prognostic variables.METHODSTwenty‐six patients with recurrent MPSC were identified retrospectively from hospital and tumor registry databases. Survival curves were generated from the time of tumor recurrence using the Kaplan–Meier method and statistical comparisons were performed using the log‐rank test, logistic regression analysis, and the Cox proportional hazards regression model.RESULTSThe median age of the patients at the time of recurrence was 46 years. The mean progression‐free interval was 31.6 months, and 92% of patients had advanced stage disease at the time of the initial diagnosis. Twenty‐one patients underwent secondary cytoreductive surgery; tumor debulking was performed in 90.5% of cases and 52.4% of patients required an intestinal resection. Optimal resection (residual disease ≤ 1 cm) was achieved in 15 patients (71.4%). Patients undergoing optimal secondary cytoreduction had a median survival time of 61.2 months from the date of disease recurrence, compared with 25.5 months for those patients in whom suboptimal residual disease remained (P< 0.02) and 29.9 months for nonsurgical patients (P< 0.01). On multivariate analysis, optimal secondary cytoreduction was found to be the only independent predictor of survival. Salvage chemotherapy produced an objective response in 25% of patients with measurable disease. The administration of chemotherapy prior to surgical intervention was associated with a trend toward worse survival and a lower likelihood of optimal secondary cytoreduction.CONCLUSIONSOptimal secondary cytoreductive surgery is feasible in the majority of patients with recurrent MPSC and is an independent predictor of subsequent survival. Surgical intervention should be considered for those patients with recurrent MPSC. [See editorials on pages 675–6 and 677–80, this issue.] Cancer 2002;95:791–800. © 2002 American Cancer Society.DOI 10.1002/cncr.10789
Stereological estimates of total neuron numbers in the hippocampus of adult reeler mutant mice: Evidence for an increased survival of Cajal‐Retzius cells
Authors: Coulin Carola , Drakew Alexander , Frotscher Michael , Deller Thomas 
Published: October 2002

AbstractThe cytoarchitecture of the brain is disrupted severely in reeler mice. This is caused by a deficiency in the protein, Reelin, which is essential for the normal migration and positioning of neurons during development. Although cell migration is clearly affected by the reeler mutation, it is believed that the total number of neurons is not. Thus, we were surprised to find an unusually large number of calretinin‐immunopositive cells, presumably Cajal‐Retzius cells, in the molecular layer of the adult reeler hippocampus (Deller et al. [1999]; Exp. Neurol. 156:239–253). This suggested that the reeler mutation affects the number of neurons in the hippocampus. In order to verify this hypothesis, unbiased stereological methods were employed. Calretinin immunostaining was used as a marker for Cajal‐Retzius cells in control as well as reeler mice and Nissl staining was used to identify hippocampal principal neurons. Total numbers of calretinin‐immunopositive cells, calretinin‐immunoreactive Cajal‐Retzius cells, and Nissl‐stained neurons were estimated in different subfields of the reeler and the control hippocampus. Stereological estimates (P < 0.05) revealed that the total number of calretinin‐immunopositive and Cajal‐Retzius cells in reeler mice are 1.5 and 2.1 times that of controls, respectively. No significant difference in total neuron number was found in any hippocampal subfield. These data demonstrate that the reeler mutation affects the number of calretinin‐immunoreactive Cajal‐Retzius cells in the adult hippocampus, probably due to a reduced excitatory innervation by entorhinal terminals in the absence of reelin. However, the reeler mutation does not affect mechanisms that determine total hippocampal neuron number. J. Comp. Neurol. 439:19–31, 2001. © 2001 Wiley‐Liss, Inc.