bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absent inner dynein arms in a fetus with familial hydrocephalus‐situs abnormality
Authors: Kosaki Kenjiro , Ikeda Kazushige , Miyakoshi Kei , Ueno Mari , Kosaki Rika , Takahashi Daisuke , Tanaka Mamoru , Torikata Chikao , Yoshimura Yasunori , Takahashi Takao 
Published: July 2004

AbstractWe report a family in which a healthy, unrelated couple had a male fetus with bilateral ventriculomegaly, a normal liveborn girl, a hydatidiform molar pregnancy, a female fetus with ventriculomegaly and situs abnormalities, and a male fetus with hydrocephalus, a three‐lobed left lung, and defective tracheal cilia with absent inner dynein arms and a single centriole. A mutation analysis of FOXJ1 and POLL in the last fetus with ciliary defect revealed no mutation within their coding regions. The presence of three affected fetuses of both sexes in a family with phenotypically normal parents suggests that the condition was inherited as an autosomal recessive trait. A thorough evaluation of the thoracic and abdominal situs is recommended before counseling a family of a child with hydrocephalus, because the recognition of situs defects may point to the diagnosis of primary ciliary defect and recurrence risk of 25% for siblings. This figure is much higher than the general risk of 1–2% for siblings of a patient with isolated hydrocephalus. © 2004 Wiley‐Liss, Inc.
Sibutramine use in pregnancy: Report of two cases
Authors: Kadioglu Mine , Ulku Cunay , Yaris Fusun , Kesim Murat , Kalyoncu Nuri Ihsan , Yaris Ersin 
Published: July 2004

AbstractBackgroundSibutramine is a drug used for the medical treatment of obesity. No data are available on sibutramine use in pregnancy. We report the fetal outcomes of two pregnant women exposed to sibutramine.CasesThe first woman was exposed to 10 mg/day of sibutramine during gestational weeks 4–6. The second woman was exposed to 10 mg/day of sibutramine during gestational weeks 5–8. At weeks 37 and 39, they delivered healthy infants.CONCLUSIONSTo our knowledge, this is the first report of sibutramine exposure in pregnancy. These cases may contribute to the knowledge about sibutramine use during pregnancy. Birth Defects Research (Part A), 2004. © 2004 Wiley‐Liss, Inc.
Visual and auditory temporal processing and early reading development
Authors: Hood Michelle , Conlon Elizabeth 
Published: July 2004

AbstractThis study investigated the ability of temporal processing measures obtained before school entry to predict early reading development in an unselected sample of 125 children (68 males, 57 females). Visual and auditory temporal order judgement (TOJ) tasks measured at Preschool (mean age 5.36 years) significantly predicted letter and word identification (accuracy) and reading rate (fluency) in early Grade 1 (mean age 5.94 years), even after the effects of age, environment, memory, attention, nonverbal ability, and speech/language problems were accounted for. There were no significant differences in the overall variance accounted for in reading between TOJ measures taken before or after reading had emerged. Both Preschool and Grade 1 measures of auditory TOJ accounted for significant independent variance in reading. However, only visual TOJ performance measured at Grade 1 accounted for unique variance in reading rate. This was discussed in terms of developmental changes in the role of visual temporal processing as reading develops. Reliability of the temporal measures from Preschool to Grade 1 was moderate. The results showed that measures of visual and auditory temporal processing obtained close to school‐entry would be a useful addition to predicting risk of early reading difficulties. Copyright © 2004 John Wiley & Sons, Ltd.
The Durham experience: promoting dyslexia and dyspraxia friendly schools
Authors: Coffield Mary , O'Neill Jenny 
Published: July 2004

AbstractThe Durham County Policy Document on Specific Learning Difficulties (dyslexia and dyspraxia) has been developed over a period of years as a countywide response to ensure that children's specific learning difficulties are identified and that schools are equipped to offer a range of appropriate interventions. The content of the policy document is studied in depth along with the training programmes offered by the Learning Support Service and Educational Psychology Service that will support schools in putting the policy into practice. Future developments, including an exciting project on promoting inclusive practice for pupils with Specific Learning Difficulties (dyslexia and dyspraxia), are outlined. Copyright © 2004 John Wiley & Sons, Ltd.
DNA damage produced in HaCaT cells by combined fluoranthene exposure and ultraviolet A irradiation
Authors: Zheng Baoying , Hwang Huey‐Min , Yu Hongtao , Ekunwe Stephen 
Published: July 2004

AbstractFluoranthene is a polycyclic aromatic hydrocarbon (PAH) and a principal constituent of PAH‐contaminated aquatic systems. In the present study, fluorescein diacetate uptake and the Comet assay were used to assess the cytotoxicity and genotoxicity of fluoranthene in HaCaT (human adult low calcium high temperature) cells in the presence or absence of ultraviolet A (UVA) irradiation. Exposure of cells to 0.1, 0.25, 0.75, 2, and 5 μM fluoranthene alone for 30 min or to 6.1 ± 0.07 J/cm2 UVA alone did not cause cytotoxicity or cellular DNA damage. However, concomitant exposure to both caused a nonlinear dose‐response in cytotoxicity to HaCat cells. The same exposure conditions also resulted in a dose‐responsive DNA damage in HaCaT cells. Because DNA damage mainly was detected at relatively high levels of cytotoxicity, we cannot rule out the possibility that it occurred as a consequence of cellular toxicity mechanisms. Environ. Mol. Mutagen. 44:151–155, 2004. © 2004 Wiley‐Liss, Inc.
Reach‐scale channel geometry of a mountain river
Authors: Wohl Ellen , Kuzma Jessica N. , Brown Nancy E. 
Published: July 2004

AbstractMountain rivers can be subject to strong constraints imposed by changes in gradient and grain size supplied by processes such as glaciation and rockfall. Nonetheless, adjustments in the channel geometry and hydraulics of mountain rivers at the reach scale can produce discernible patterns analogous to those in fully alluvial rivers. Mountain rivers can differ in that imposed reach‐scale gradient is an especially important control on reach‐scale channel characteristics, as indicated by examination of North St Vrain Creek in Colorado.North St Vrain Creek drains 250 km2 of the Rocky Mountains. We used 25 study reaches within the basin to examine controls on reach‐scale channel geometry. Variables measured included channel geometry, large woody debris, grain size, and mean velocity. Drainage area at the study reaches ranged from 2·2 to 245 km2, and gradient from 0·013 to 0·147 m m−1.We examined correlations among (1) potential reach‐scale response variables describing channel bankfull dimension and shape, hydraulics, bedform wavelength and amplitude, grain size, ﬂow resistance, standard deviation of hydraulic radius, and volume of large woody debris, and (2) potential control variables that change progressively downstream (drainage area, discharge) or that are likely to reﬂect a reach‐speciﬁc control (bed gradient). We tested the hypothesis that response variables correlate most strongly with local bed gradient because of the segmented nature of mountain channels.Results from simple linear regression analyses indicate that most response variables correlate best with gradient, although channel width and width/depth ratio correlate best with discharge. Multiple regression analyses using Mallow's Cp selection criterion and log‐transformation of all variables produced similar results in that most response variables correlate strongly with gradient. These results suggest that the hypothesis is partially supported: channel bed gradient is likely to be a good predictor for many reach‐scale response variables along mountain rivers, but discharge is also an important predictor for some response variables. Copyright © 2004 John Wiley & Sons, Ltd.
Determining the hemispheric dominance of spatial attention: A comparison between fTCD and fMRI
Authors: Jansen Andreas , Flöel Agnes , Deppe Michael , van Randenborgh Jutta , Dräger Bianca , Kanowski Martin , Knecht Stefan 
Published: July 2004

AbstractHuman brain mapping allows the systematic assessment of interindividual differences in functional brain anatomy. Functional transcranial Doppler sonography (fTCD) is an imaging tool that allows for fast and mobile assessment of hemispheric lateralization of task‐related brain activation. It is ideal to screen large cohorts of subjects. The goal of the present study was to investigate whether fTCD and functional magnetic resonance imaging (fMRI) determine hemispheric lateralization of brain activation related to visuospatial attention concordantly. Used together, fMRI and fTCD may then open up a wide range of potential applications in neuroscience. Fifteen subjects were examined both with fTCD and fMRI while they judged accuracy of line bisections (Landmark task). For fTCD, the maximal mean difference in stimulus‐related relative cerebral blood flow velocity changes in the left and right middle cerebral arteries was assessed as the lateralization index LIfTCD. For fMRI, two approaches were used to determine hemispheric dominance. First, we measured brain activity as the extent of the activated region, i.e., the number of activated voxels above a statistical threshold. Second, we calculated the magnitude of the fMRI signal change between the activation and the control task within a region of interest. Results of fTCD and fMRI were concordant in every single case. Therefore, scanning large cohorts with fTCD for hemispheric dominance during Landmark task will provide results consistent with fMRI. FMRI can then be used for in depth assessment of the specific patterns of activation. Hum Brain Mapp 23:168–180, 2004. © 2004 Wiley‐Liss, Inc.
What do students want? Perspectives from the front line of doctoral training in professional and Combined‐Integrated psychology
Authors: Braxton H. Harrison , Volker Martin A. , Loftis Christopher , Williams‐Nickelson Carol , Schulte Timothy J. , Kassinove Jeffrey I. , Tarquin Kristen , Scime Melinda 
Published: July 2004

AbstractDoctoral students in professional psychology face broad challenges, such as changing market demands and increased competition for careers in traditional practice settings. To prepare for these demands, students must decide how much and when to specialize, if at all, predoctorally. Complicating matters, students in single practice area programs (clinical, counseling, or school) may risk becoming insulated within the culture of their practice area, which can limit exposure and understanding of the larger practice field. Despite conditions that may drive potential students away from psychology, little research exists on efforts to address student needs, or on student perspectives of doctoral training in general. One training model that is sensitive to these student needs and concerns is the Combined‐Integrated (C‐I) model. An exploratory study of C‐I student and graduate opinions, experiences, and aspirations revealed that C‐I students value breadth of training, diversity of experience, and professional flexibility, and that they experience diverse training opportunities and socialization experiences. Implications of these results vis‐à‐vis the larger framework of student concerns are examined. © 2004 Wiley Periodicals, Inc. J Clin Psychol.
Raman bandshape analysis of o‐chlorobenzaldehyde: microviscosity‐dependent study
Authors: Gomti Devi Th. , Kumar Kamal 
Published: July 2004

AbstractIsotropic Raman bandshape analysis was carried out for the CO stretching mode of o‐chlorobenzaldehyde using various polar and non‐polar solvents as a function of the solvents' hydrodynamic properties. The bandwidths of the isotropic components were measured at high dilution where the bandshape approaches Lorentzian. The effect of solvent viscosity on bandwidth was studied in details. It is clear that macroscopic consideration of the hydrodynamic force is not sufficient to correlate the vibrational relaxation rate (τv−1) with the parameter f(ρ, η, n), involving dynamic viscosity. The bandshape analysis was carried out taking the microviscosity into account using the parameter fm. The parameter fm shows a better correlation than f(ρ, η, n). Copyright © 2004 John Wiley & Sons, Ltd.
Contact ion pairs: a quantitative Raman study of the NaClO3–DMF system
Authors: Alves Wagner A. , Téllez S Claudio A. , Hollauer Eduardo , Faria Roberto B. 
Published: July 2004

AbstractRaman spectra of sodium chlorate in N,N‐dimethylformamide (DMF) solution were obtained. The band at 926 cm−1 that has been previously assigned to the vibrational mode of the associated chlorate with Cs symmetry is, in fact, due to the non‐associated chlorate vibration with C3v symmetry. In the ν2 region of the chlorate anion, a new feature at 600 cm−1 was observed and the results show that it also belongs to the non‐associated chlorate. Both bands at 926 and 600 cm−1 are assigned to the vibrations involving O37ClO, in full agreement with the results of normal coordinate analysis reported by others workers. Quantitative measurements performed in the range 590–630 cm−1, allowed the determination of the extent of contact ion pair formation. The results show that the ion association in the NaClO3–DMF system is significantly greater than in the NaClO4–DMF system and this is due the higher charge density and lower symmetry of the chlorate anion. Similar conclusions were reached by others who used different experimental techniques. Copyright © 2004 John Wiley & Sons, Ltd.
Exploring children's choice: The reminder effect of product placement
Authors: Auty Susan , Lewis Charlie 
Published: July 2004

AbstractThere has been little attempt to understand the influence on children of branded products that appear in television programs and movies. A study exposed children of two different age groups (6–7 and 11–12) in classrooms to a brief film clip. They were then individually asked to demonstrate their witness skills by describing in as much detail as possible what they had seen. Half of each class was shown a scene from Home Alone that shows Pepsi Cola being spilled during a meal. The other half was shown a similar clip from Home Alone but without branded products. All children were invited to help themselves from a choice of Pepsi or Coke at the outset of the individual interviews. Those who had seen the branded clip made a significantly different choice of drink. The responses to the interviews suggest that it is not simply exposure to the film but rather previous exposure together with a reminder in the form of recent exposure that affects choice. Age (and by implication processing skill) does not appear to be a mediating factor affecting choice, because implicit memory (mere exposure) seems to be more important than explicit recall. © 2004 Wiley Periodicals, Inc.
Werkstoffverhalten unter zügiger elastischer Beanspruchung
Authors: Evertz Th. , Sonne H.‐M. , Steinbeck G. , Engl B. 
Published: July 2004

AbstractIm Rahmen eines gemeinschaftlichen Projektes der Stahl‐ und Automobilindustrie wurden an insgesamt 20 Stählen für Feinblech Kennwerte für die FE‐Simulation ermittelt. Im Einzelnen handelte es sich um elastische, plastische und zyklische Kennwerte, die über einen Zeitraum von 3 Jahren von unterschiedlichen Prüfstellen erarbeitet wurden. Die Bedeutung des temperatur‐ und richtungsabhängigen E‐Moduls für den Automobilbau ist in der Rückfederung beim Pressen von Blechen und der Steifigkeit von Automobilteilen begründet. Der E‐Modul wurde mit dem Zugversuch für den Anlieferungszustand, nach Vorverformung und teilweise nach Wärmebehandlung bei Raumtemperatur sowie bei –40 °C und 100 °C ermittelt. Der E‐Modul ist aufgrund der Walzbedingungen richtungsabhängig und kann in Gruppen zusammengefasst werden. Bereits eine Vorverformung von 2 % verursacht für ferritische Stähle eine Verringerung des E‐Moduls um ca. 10 %. Nach einer Wärmebehandlung bei 170 °C erholt sich der E‐Modul weitgehend. Die aus zerstörungsfreien Verfahren bekannte Temperaturabhängigkeit konnte bestätigt werden.
Basal prostate epithelial cells stimulate the migration of prostate cancer cells
Authors: Yu Hsiao‐Man , Frank Diane E. , Zhang Jie , You Xueke , Carter William G. , Knudsen Beatrice S. 
Published: July 2004

AbstractCarcinoma cells in PIN are situated above a layer of basal epithelial cells, which shield the tumor cells from stimulation by factors from the prostate stroma. During progression to invasive carcinoma, the basal cell layer becomes disrupted and tumor cells adhere to the basement membrane. The close proximity of basal epithelial cells to tumor cells in the early stages of prostate oncogenesis raises the possibility that basal epithelial cells participate in tumor cell invasion. Here, we investigated the migration‐promoting activity of secreted factors from basal epithelial cells on BPH‐1 cells, which we used as an in vitro model of preinvasive prostate cancer cells. We showed that the conditioned medium of basal epithelial cells (PEC‐CM) contains adhesion proteins and chemotactic factors that stimulate adhesion, planar polarization, migration, and phosphorylation of Akt and that LY294002 and Wortmannin partially inhibit PEC‐CM‐triggered migration. We identified laminin‐5 as a major migration‐stimulating protein for BPH‐1 cells in PEC‐CM. Laminin‐5 induced migration is completely inhibited by LY294002 or Wortmannin. In addition, antibody‐depletion of laminin‐5 from PEC‐CM significantly diminishes the migration of BPH‐1 cells. These results demonstrated, that laminin‐5 is secreted by basal prostate epithelial cells in vivo and in vitro and stimulates migration of BPH‐1 cells through a PI3‐kinase dependent mechanism. Altogether, the possibility that basal epithelial cells assist in the invasion of in situ carcinoma cells is supported by the results from our in vitro system. © 2004 Wiley‐Liss, Inc.
Incidence of vascular hemiballism in the population of Belgrade
Authors: Pekmezović Tatjana , Svetel Marina , Ristić Aleksandar , Raičević Ranko , Ivanović Nataša , Smiljković Tatjana , Kostić Vladimir S. 
Published: July 2004

AbstractHemiballism is a relatively rare hyperkinetic disorder with unknown incidence. Stroke is the most common cause of hemiballism (vascular hemiballism), responsible for the disorder in 50% to 100% of cases. We studied the incidence of vascular hemiballism in the population of Belgrade (Serbia) 40 years of age or older during the period 1 January 1991 to 31 December 2002. During that time period, 37 patients with hemiballism due to stroke were diagnosed. The annual incidence rates varied from 0.14 to 0.87/100,000 (average 0.45/100,000) of general population. © 2004 Movement Disorder Society
Rapid‐onset dystonia–parkinsonism: A fourth family consistent with linkage to chromosome 19q13
Authors: Zaremba Jacek , Mierzewska Hanna , Lysiak Zofia , Kramer Patricia , Ozelius Laurie J. , Brashear Allison 
Published: July 2004

AbstractRapid‐onset dystonia–parkinsonism (RDP, DYT12, MIM 128235) is a rare autosomal dominant movement disorder characterized by abrupt onset of slow, dystonic movements and prominent bulbar features. Three families and 1 isolated case have been described in the literature, and linkage to markers on chromosome 19q13 have been reported. Here, we describe the clinical features in a fourth family (the second in Europe) with 4 affected members, suggesting that RDP may be misdiagnosed for years and/or may mimic other dystonic/parkinsonian syndromes. By using haplotype analysis, we show that the family is consistent with linkage to markers on chromosome 19q13. © 2004 Movement Disorder Society
Effect of chemically defined culture medium supplemented with β‐mercaptoethanol and amino acids on implantation and development of different stage in vivo‐ or in vitro‐derived mouse embryos
Authors: Bagis H. , Odaman Mercan H. 
Published: July 2004

AbstractIn vitro culture (IVC) systems are required for many biotechnological and assisted reproductive technologies and the researchers have been modifying in vitro embryo culture conditions to reach the comparable efficiencies provided in vivo. In the present study, the effects of β‐mercaptoethanol (β‐ME) and amino acids (AA) on the development of mouse embryos obtained in vivo or in vitro at different stages were investigated. Chemically defined potassium simplex optimized medium (KSOM) was used as basic culture medium and six experimental groups were established and by supplementation of β‐ME and AA into KSOM media. The quality of blastocysts was evaluated by counting the cells and determining the ratio of inner cell mass (ICM) to trophoectoderm (TE) cells. In addition, embryo transfer (ET) was performed to investigate the rate of implantation and live fetuses. The results obtained in the present study demonstrated that the combined treatment of β‐ME and AA to 1‐cell stage embryos not only enhanced in vitro development to the blastocyst stage but also improved both the number of blastocysts cells and live fetuses. Mol. Reprod. Dev. 69: 52–59, 2004. © 2004 Wiley‐Liss, Inc.
Sexing of in vitro produced ovine embryos by duplex PCR
Authors: Mara L. , Pilichi S. , Sanna A. , Accardo C. , Chessa B. , Chessa F. , Dattena M. , Bomboi G. , Cappai P. 
Published: July 2004

AbstractThe aim of this article was to develop a fast and easy duplex polymerase chain reaction (PCR) method, for sex determination of ovine in vitro produced embryos prior to implantation. We tested the approach with 107 samples of autosomal cells (oviductal sheep cells and male lamb fibroblasts), divided into three groups for each sex according to the number of cells employed (30, 5, 2, respectively). We then used the test on 21 embryos at blastocyst stage. On the same day the embryos were transferred in pairs into 11 recipient synchronized ewes. The PCR utilized two different sets of primers: the first pair recognized a bovine Y‐chromosome‐specific sequence (SRY), that showed 100% homology with the corresponding sequence of the ovine Y‐chromosome and is amplified in males only. The second pair recognized the bovine 1.715 satellite DNA (SAT) which was amplified in all ovine samples but, when submitted to the GenBank database did not show homology with any of the reported ovine sequences. However, after sequencing, ovine amplification product showed 98% homology with the bovine specific satellite sequence. The autosomal samples were amplified with 85.0% efficiency and 91.2% accuracy, while amplification was successful with all 21 embryos (100% efficiency). Eight lambs were born and the sex as determined by PCR corresponded to the anatomical sex in seven (87.5% accuracy). These results confirm that this method can be applied in ovine breeding programs to manipulate sex ratio of offspring. Mol. Reprod. Dev. 69: 35–42, 2004. © 2004 Wiley‐Liss, Inc.