bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal ultrasound diagnosis of a rare case of Morgagni hernia with liver herniation into the pericardium: a case report
Authors: Li Tao , Ma Bin , Nie Fang 
Published: November 2023

Abstract
A Morgagni hernia is a rare type of congenital diaphragmatic hernia (CDH) that accounts for 3% of all CDH cases. Among the types of Morgagni hernias, a particularly rare form exists, which is characterized by a central defect involving both the diaphragm and pericardium. In such cases, the liver herniates into the pericardial cavity. Accurate prenatal diagnosis is beneficial for the management of affected fetuses and newborns.
The synergistic effect of mono and co-exposure of microplastic suspensions on Daphnia magna’s survival, population density, reproduction rate &amp; swimming behavior.
Authors: Shafiq Hassan , Amjad Hira , Hashmi Imran , Ali Mariam 
Published: November 2023

Abstract
Microplastics represent a pervasive contaminant in aquatic ecosystems, posing substantial risks to aquatic biota. This study sought to elucidate the toxicological impacts of three prevalent plastic polymers high-density polyethylene (HDPE), low-density polyethylene (LDPE), and polypropylene (PP) in both mono and co-exposure scenarios on Daphnia. Employing a range of toxicological endpoints, investigation assessed Daphnia magna's ingestion, bioaccumulation, population density, swimming behavior, and reproduction rate in response to microplastics measuring 0–32 µm, which were synthesized in laboratory using virgin polymer beads. The findings revealed that synergistic effects of microplastics in a co-exposure medium pose a greater hazard to the organism than mono-exposure to individual microplastics (PP, LDPE, and HDPE). In co-exposure scenerio, LC50 value decreased to 77 mg/L, compared to 120, 123, and 109 mg/L for PP, LDPE, and HDPE, respectively. Daphnia magna exhibited a more pronounced response to co-exposure, characterized by reduced survival rates, increased microplastic ingestion, reduced reproduction rates and population densities. Furthermore, co-exposure scenarios led to increased erratic swimming movements relative to mono-exposure, with immobility and energy deficiency observed across all exposure types, albeit with a greater magnitude in co-exposure settings.
AS1411-bivalent-cholesterol-anchor equipped with Zinc phthalocyanine enables NK cells derived exosomes to realize effective tumor-tropism photodynamic therapy
Authors: Qi Yuchen , Hao Jie , Zeng Tian , Zhou Jie , Dong Yan , Shu Qiuxia , Weng Qin , Yu Hua , Zhao Xiang , Li Jianjun 
Published: November 2023

Abstract
Benefitting from their outstanding tumor-penetrating ability and cytotoxic proteins and cytokines, natural killer cell-derived exosomes (NEX) show great potential for cell-free tumor immunotherapy. To meet the clinical tumor therapeutic need, engineered NEX are highly required to further enhance their tumor-tropism and anti-tumor abilities. Thus, we firstly proposed a NEX engineering strategy, using a structure of AS1411-bivalent-cholesterol (B-Chol)-anchor equipped with photosensitizer Zinc phthalocyanine (ZnPc) attached on the membrane of NEX, to form A-P-NEX. It not only preferably maintains the spatial structure of the AS1411 aptamer via B-Chol anchor contributing to the tumor-tropism and the stability of NEX, but also significantly improve the photodynamic therapy (PDT) effect by firmly binding ZnPc in the unique G-quadruplex structure in AS1411 aptamer. Thus, the results showed A-P-NEX could promote the precisely uptake of NEX and ZnPc by tumor cells, and produce obvious synergistic NEX-based immunotherapy and PDT upon laser irradiation, demonstrating excellent targeted anti-tumor effects both in vitro and in vivo. This study demonstrates a reliable NEX-engineering strategy, and paves the way for developing useful tumor-tropism PDT method.
Postprandial lipid profile characteristics and their influencing factors in Chinese healthy volunteers with normal fasting blood lipids
Authors: He Yingxia , Yao Fang , Lu Pan , Cao Dan , Wang Qingqing , Huang Tao , Wang Jie , Xie Yafang , Li Xiuwen , Liu Qiangwei , Liu Yang , Zhao Lihui , Chen Lifeng , Liu Guan 
Published: November 2023

Abstract
Objective
To investigated the impact of an oral fat tolerance test (OFTT) on plasma lipid levels in a group of healthy Chinese volunteers with normal fasting blood lipids and analyze the factors influencing the 4-hour postprandial triglycerides (TG) levels. In order to provide reference recommendations for controlling postprandial lipid levels specifically in Chinese population.
Methods
A total of 304 healthy volunteers from the Research Center of Wuhan Pulmonary Hospital enrolled in the pharmacokinetic (PK) study of the drug clinical trial in the postprandial group from 2021 to 2022 were included. General information such as gender, age, body mass index (BMI), blood pressure, pulse and daily habits (diet, exercise etc.) were collected after obtaining informed consent. The remained plasma samples after PK studies under high-fat diet conditions were collected for lipid testing. The impact of OFTT on plasma lipid profile was investigated, and the influence factors correlated with 4-hour postprandial TG were analyzed.
Results
We observed significant elevation in postprandial TG levels, while there was a temporary and slight decrease in HDL-C, LDL-C and ApoB levels after the OFTT in healthy volunteers with normal fasting lipid levels. However, no significant difference was found between fasting and postprandial TC levels. The 4-hour postprandial TG levels observed after the OFTT exhibited a significant positive correlated with advanced age (p<0.0001), elevated BMI (p<0.005), and increased fasting TG levels (p<0.0001) as determined through Pearson and Spearman correlation analysis. Interestingly, approximately half of these healthy volunteers with normal fasting blood lipids exhibited abnormal postprandial TG levels. Additionally, a small proportion of the population dose not response to the OFTT.
Conclusion
Conducting an OFTT is essential for early evaluating the risk of cardiovascular diseases (CADs) and providing guidance for maintaining healthy lipid levels in the Chinese population.
The Magnetic Microbolometer: a proposal for QUBIC Next Gen
Authors: Hampel Matías , Almela Alejandro , Bonaparte Juan , Neira Jesús Bonilla , Ferreyro Luciano , Fuster Alan , Redondo Manuel García , Gartmann Robert , Geria Juan , Müller Nahuel , Muscheid Timo , Salum Juan , Platino Manuel , Ardila Luis , Sander Oliver , Wegner Mathias , Kempf Sebastian , Weber Marc , Etchegoyen Alberto 
Published: November 2023

Abstract

In this paper, the proposal for a new multichroic pixel camera for the QUBIC instrument is presented, which aims to measure the B-mode polarization of the Cosmic Microwave Background. The camera features antenna-coupled magnetic microbolometers (MMB) read out by a microwave SQUID multiplexer and software-defined radio-based room temperature electronics, which are specifically optimized for MMB readout. The architecture of the detectors and their readout system is introduced, and the main design considerations are also discussed.The initial results of the simulation study suggest that MMBs are capable of achieving background limited detection of the sky when used in an instrument like QUBIC. Additionally, the time response of these detectors appears to be sufficiently fast for the given telescope scan speed and beam size.
Obtaining artifact-corrected signals in fiber photometry: Isosbestic signals, robust regression and dF/F calculations
Authors: Keevers Luke J. , McNally Gavan P. , Jean-Richard-dit-Bressel Philip 
Published: November 2023

Abstract
Fiber photometry is a powerful tool to measure a wide variety of dynamics from targeted cell populations and circuits in freely-behaving animals. However, measured biosensor signals are contaminated by various artifacts (photobleaching, movement-related, noise) that undermine analysis and interpretation. Here, we consider existing approaches for obtaining artifact-corrected neural dynamic signals from fiber photometry data. We show using real and simulated photometry data that a specific form of robust regression, iteratively reweighted least squares (IRLS), is preferable to ordinary least squares (OLS) regression for fitting isosbestic signals to experimental signals. We also demonstrate the efficacy of low-pass filtering signals and baseline-normalization via dF/F calculations. Considerations and recommendations for analyses, including methods for detrending and normalization are discussed.
The Prevalence and Post-Operative Complications of Uterine Leiomyomas in South-Western Nigeria and Northern Nigeria: A Comparartive Review
Authors: Anaziah Grace 
Published: November 2023

Abstract
Background: Uterine Leiomyoma are benign tumors which commonly affect women of reproductive age, however only a subset of women has their fibroids clinically detected, symptomatic or warrant surgical treatment. Its removal is associated with complications. To control the occurrence of this complication requires the understanding of the factors associated with the complications.
Methods: The study was carried at two large tertiary hospitals in South-western and Northern region of Nigeria. It was a descriptive cross-sectional study that was conducted among patients in these regions. Information such as sociodemographic characteristics was recorded in questionnaire including retrospective review of case records of all surgically managed cases of uterine leiomyoma (from one hundred and fifty-nine women) was obtained after formal consent from the hospital’s ethics committee.
Results: In Both regions of Nigeria, the common presenting complaints from 36-40 years old patients were menstrual irregularities, Abdominal swelling, and infertility. The commonest anatomical position of the nodules were multiple positions and intramural.
The majority (79.9%) of the women in South-Western Nigeria presented with multiple leiomyomas. While the majority (48.8%) of the women in Northern Nigeria presented multiple leiomyomas which accounted for almost half of the patients diagnosed in that region. In the South-western region of Nigeria, post-operative complications occurred in 20.9 % of cases with post-operative pyrexia (13.5%), blood loss warranting transfusion (12.8%) and post-operative anemia (10.4%) been the most common complications. While in the Northern region of Nigeria no complications were recorded.
Conclusion: Uterine leiomyomas is common in Nigeria and usually presents with menorrhagia, pelvic pain, recurrent miscarriage, and infertility. The surgery may be complicated by post operative pyrexia, blood loss, wound infection and even death. Midline incision, closure of rectus sheet with chromic catgut and myomectomy were associated with postoperative complications in this review. To avoid postoperative morbidities associated with surgical management of fibroid, Pfannenstiel incision where feasible, use of non-absorbable or delayed absorbable sutures and hysterectomy in women who have completed family should be adopted in the Southwestern region of Nigeria. Whereas prevalence of uterine leiomyomas is generally prevalent in the Southwest, there are varying age prevalence’s in the North and Southwest.
Prediction of uniform temperature of rectangular hollow concrete pier based on measured temperature data
Authors: Chen ShunChao , Wu Wenxiang , Yun Jianzhou , Mao Shihua , Yu Yue 
Published: November 2023

Abstract
The standard value of uniform temperature action for bridges is more loosely defined in local bridge design codes. Currently, there is an increasing tendency to determine the range of variation of uniform temperature of bridges based on air temperature information from various locations. In this study, in order to accurately and conveniently predict the range of temperature change of concrete during the design reference period. The temperature distribution of concrete rectangular hollow piers of Changjiahe Special Bridge was observed for 212 days. According to the observation data, the average temperature of the concrete hollow pier was studied as a function of the outside air temperature and the air temperature inside the hollow pier. The method of predicting the range of variation of the average concrete temperature according to the local air temperature material is proposed; the method of predicting the time-by-time uniform temperature of the concrete hollow pier based on the same temperature data inside and outside the hollow pier is proposed. The research results show that: the average temperature change rule of concrete hollow piers and air temperature, are presented day by day cycle and step change, and the hollow pier average temperature extremes appear time lagging behind the air temperature; day maximum, day minimum hollow pier average temperature and the average daily air temperature is linearly correlated between the average daily air temperature, the average daily air temperature, average daily air temperature inside the pier and the average daily hollow pier temperature is linearly correlated between the average daily air temperature and the average daily hollow pier temperature; the average temperature of the hollow pier The magnitude of change is less than the air temperature, hollow pier average temperature daily variation and air temperature daily difference is approximately linear; concrete hollow pier average temperature prediction and measured values, the maximum difference between − 1.1 ~ 0.8 ºC; in the design reference period, in the day of the highest, lowest daily average air temperature on the basis of an increase of 2 degrees Celsius, can be obtained from the range of uniform temperature changes in the bridge abutment.
Theoretical and Experimental Study of Linear Momentum Contours in pristine and aged Nafion 117 Membranes
Authors: Zinola Carlos F. 
Published: November 2023

Abstract
The long-time operation stability of Nafion membranes upon large current densities is important for the durability of polymer electrolyte fuel cells. It was found that under laminar regimes, medium porosities and relative low Reynolds (Graetz) numbers, the Darcy-Brinkman equation can be fully applied. Flow rate preferential paths inside the initial homogenous porous medium are formed in an aged specimen (2 years of operation at 1 A cm-2) and define the effective flow at the connecting interface with the inviscid fluid. The process is modelled by the introduction of a convective term in the Darcy-Brinkman equation which renders an analytical solution for linear velocities that is well related to experimental results. The theoretical values are compared with experimental data obtained from a thin-film prismatic tube with Nafion 117 membranes using distinct hydrodynamic conditions under the flow of an acidic water solution. The resolution of the velocity equations is also conducted for the pristine sample showing different results that can be extrapolated under the certain experimental working conditions. The friction factor is calculated for the pristine and aged specimens showing distinct values for Graetz numbers lower than 80, being 4 times higher for the brand new membrane. Furthermore, equivalent behaviours for both samples are shown for Graetz numbers higher than 200 when a porosity/Darcy number ratio of 313 is used.
Design and development of a 224-pixel TES X-ray microcalorimeter system for microanalysis with STEM
Authors: Hayashi Tasuku , Miyagawa Rikuta , Yagi Yuta , Tanaka Keita , Ota Ryo , Yamasaki Noriko Y. , Mitsuda Kazuhisa , Maehata Keisuke , Hara Toru 
Published: November 2023

Abstract

Studies of astromaterials, including sample return missions such as HAYABUSA2 and OSIRIS-REX, provide valuable insights into the formation and evolution of the solar system. Astromaterials consist of both organic and inorganic materials containing various types and amounts of elements. To analyze such astromaterials on a sub-micrometer scale, one of the most useful tools is energy-dispersive X-ray spectroscopy (EDS) in conjunction with scanning transmission electron microscope (STEM). We developed an analysis method for determining the concentration of astromaterials using a transition edge sensor (TES) X-ray microcalorimeter. The conventional semiconductor-based EDS system is sometimes insufficient to resolve emission lines at closely adjacent energies. The TES X-ray microcalorimeter is a promising solution to overcome this problem. We developed a 64-pixel TES X-ray microcalorimeter array with two different-thickness absorbers in the same device for the broadband X-ray, which had an energy resolution of approximately 7 eV (FWHM) at an energy band from B Kα (183 eV) to Cu Kα (8 keV) [1]. However, the counting rate was only approximately 1000 count/(s∙array), which is not enough for astromaterial analysis, as a longer observation time will lead to sample damage. The counting rate was limited by the number of pixels and effective area.A simple solution to increase the counting rate is to use many pixels and a large absorber. An X-ray event from a sample was focused by poly-capillary X-ray optics to increase the solid angle of the specimen in the STEM-EDS system. We calculated the photon map on the detector surface using the Monte Carlo simulation of poly-capillary X-ray optics [2]. Based on the simulations, we arranged the pixels within a diameter of 4.8 mm, with 224 pixels packed tightly. By fabricating a cantilevered gold absorber to cover the dead space of the electrodes, we achieved a 15-fold increase in the effective area. For large absorbers,the residual resistivity ratio (RRR) is an indicator of thermal diffusion and limits the TES performance. We introduced an electroplating environment of gold and obtained an RRR of approximately 23. A large absorber was fabricated using this electroplating environment in conjunction with a double photoresist layer process. In a test chip, we confirmed the performance of one pixel, which had a critical temperature of 160 mK and an energy resolution of approximately 10 eV. In this paper, we provide more details of the Monte Carlo simulation, fabrication process of the overhang absorber, and device performance.
Abstract differential equations and $L^{q,\al} $-Hölder functions
Authors: Hernandez Eduardo , Lisboa Lucas , Fernandes Denis 
Published: November 2023

Abstract
We introduce the class of Lq,a-Hölder functions and study the local and global existence and uniqueness of solution for abstract evolution differential equations assuming that the non-linear term is a Lq,a-Hölder function. In the last section, some examples with applications to partial differential equations are presented.
2010 MSC: 34G10, 34G20, 47D06.
Identifying climate refugia through analysis of functional diversity
Authors: Gissi Elena , McDevitt-Irwin Jamie M. , Kaschner Kristin , Kesner-Reyes Kathleen , Hazen Elliott , Santoleri Rosalia , Micheli Fiorenza 
Published: November 2023

Abstract
Understanding how climate change will influence ecosystems is essential for effective climate adaptation and mitigation. Current approaches in ocean management aim to protect climate refugia, defined as areas where species will persistent over time, or areas where climatic conditions are projected to be more stable. However, these approaches overlook complex shifts in functional diversity of community assemblages resulting from climate-induced species turnover. Here, we approach climate refugia for marine megafauna in the Northeast Pacific ocean from the lens of functional diversity in comparison with species diversity. We find that species turnover explains species and functional diversity change by the year 2100 in the extreme climatic scenario better than in the moderate and intermediate scenarios. Functional diversity is more stable at temperate and tropical latitudes than at poleward latitudes. Our results show that fewer, less abundant species influence functional diversity change across ecoregions. These results highlight opportunities to target conservation on certain species in areas where they support functional diversity. Our approach can assist managers to identify and protect areas that might lose species but not functional diversity. This will help maintaining ecosystem resilience, their capacity to buffer multiple disturbances and to provide benefits to humans across future climate change scenarios.
Assessment of Key Determinants of Cardiometabolic Syndrome among Adult Patients in Uganda: an Institutional Based Study
Authors: Sawani Ivan , Byonanuwe Simon , Alina Peris , Nabirye Stella , Lagoro Charles 
Published: November 2023

Abstract
Introduction:
Uganda, like other developing countries is experiencing an increasing burden of non communicable diseases. A few studies conducted in sub-Saharan Africa have shown that the incidence of cardiometabolic syndrome is rapidly approaching that of the developed nations. Information regarding key determinants for this anomaly among the Ugandan population in many parts of the country however remains scanty despite the associated morbidity
Methods
A 3-months cross-sectional study involving 383 adult participants was conducted from November 2022 to January 2023 at Fortportal regional referral hospital medical outpatient clinic. Interviewer administered questionnaires and laboratory report forms were used to obtain data. Descriptive statistics followed by binary logistic regression were conducted using IBM SPSS 20
Results
136(36%) of the 383 participants had CS. Daily physical activity of > 30 minutes (aOR = 0.70; 95%CI: 0.46–0.91, p = 0.003) was protective for CS while BMI > 24 kg/m2 (aOR = 4.25; 95%CI: 1.17–5.59, p = 0.001) was significantly associated with high odds for CS (p < 0.05)
Conclusion
Daily physical activity and BMI are the key determinants of CS at this facility. Preventive lifestyle interventions should be targeted at lowering BMI and promoting daily physical exercises in this area.