bluuebunny/crossref_metadata_2025_split huggingface dataset:
The chemokine CXCL7 is correlated with LDH-A and predicts the prognosis of patients with colorectal cancer
Authors: liang hai , Li Longhai , huang baoyu , Jiang Rongyan , Cheng Gang , ao jiafu , Hao Shuli 
Published: January 2024

Abstract

Objective: The aims of this study were to evaluate the correlation between CXCL7 expression and glycolysis and to explore the prognostic significance of CXCL7 in colorectal cancer (CRC). Methods: The expression of CXCL7 and LDH-A was measured by immunohistochemistry in tissue from 158 CRC patients. Patients were divided into high expression and low expression groups based on receiver operating characteristic curves and a cut-off value. The correlation between CXCL7 and LDH-A expression was evaluated. The overall survival (OS) times of CRC patients were explored. The risk factors related to prognosis were assessed. Results: Significantly higher expression of CXCL7 and LDH-A was detected in CRC tissue than in non-CRC tissue, and was associated with N stage and TNM stage. CXCL7 expression was strongly correlated with LDH-A expression in CRC tissue. High expression of CXCL7 was validated as an independent risk factor for OS. Conclusion: Increased expression of CXCL7 was positively correlated with LDH-A expression and was an independent risk factor for CRC prognosis.
Assessment of COVID-19 Numbers by Using Fisher Transform Indicator
Authors: Nutku Ferhat 
Published: January 2024

Abstract
New cases, new deaths, new deaths per new cases numbers belonging to COVID-19 pandemic investigated via open, high, low, close candlesticks and Fisher transform indicator. Candlestick plots, accompanied by crossovers in the Fisher transform indicator, facilitate the determination of the beginning of upward and downward trends in numbers, clearly and in a timely manner. It has been shown that an increase in the total number of peaks over time, in both smoothed candlestick data and in the Fisher transform indicator, can indicate the temporary or persistent diminishing of a pandemic.
Domesticated Animal Reservoirs of Cryptosporidium and Giardia in Agricultural Farms in Laguna and Quezon Province, Philippines
Authors: Paller Vachel Gay Velasco , Macaraig Jeph Roxy , Mendoza David Lester 
Published: January 2024

Abstract

Cryptosporidium and Giardia are recognized as significant etiological agents of diarrheal outbreaks in humans as these parasites may be transmitted through the ingestion of water and food contaminated with feces of human or animal origin. However, surveillance studies on the role of animal reservoirs in the transmission of Cryptosporidium and Giardia are deemed insufficient and the complete dimension of the problem contributing to contamination in an agricultural setting is unknown. This study aimed to assess the presence of Cryptosporidium and Giardia in domesticated animals from selected farms in the agricultural provinces of Laguna and Quezon in Southern Luzon, Philippines. Using immunofluorescence assay, an overall 85.7% prevalence of protozoan infection was recorded among the animals (N = 161). Of these, 77.0% and 73.9% were positive for Cryptosporidium and Giardia, respectively. Highest prevalence (95.83%) of Cryptosporidium was documented in swine and the highest prevalence (89.47%) of Giardia was observed in ruminants. Analyses revealed significant differences in the prevalence of the protozoan parasites among animals with different containment status, water source, age group, and sex. On the other hand, farm workers’ knowledge on parasite transmission was negatively correlated (p = 0.001) to parasite prevalence. With the scarcity of data about Cryptosporidium and Giardia in farm-raised animals in the Philippines, the information obtained from this study will be vital for protozoan source tracking and further control interventions against Cryptosporidium and Giardia infections.
Effects of corn silage and corn silage with hay from xerophytic plants on sheep feeding
Authors: Menezes Rosilda Alves Magalhães , Queiroz Mário Adriano Ávila , de Carvalho Francisco Allan Leandro , Neto João Virgínio Emerenciano , Campos Fleming Sena , Batista Perecles Brito , Bezerra Higor Fábio Carvalho , Almeida Bruno Augusto de Souza 
Published: January 2024

Abstract

The objective of this study was to evaluate the effects of partial inclusion of xerophyte hay in corn silage in the diet of twenty entire male sheep without a defined breed standard (NDRS) distributed in four diets with corn silage (CS), corn silage with gliricidia hay (CSG), corn silage with pornunça hay (CSP), corn silage with leucaena hay (CSL), evaluated using a completely randomized block design with five replications, which was established based on body weight initial 18 ± 2 kg. The differences observed in dry matter consumption (DM) and crude protein (CP) indicated higher levels for CSG (1.54 kg/day) and CSP (0.15 kg/day). The digestibility IVDDM (70.35%) and IVDNDF (60.31%) were superior for DM and average daily gain (ADG), as well as the best FC (= 6.93 kg). Mostly, the effects (P < 0.05) were obtained in the cuts, shoulder (P = 0.01), neck (P = 0.01), rib (P = 0.03), shank (P = 0.03), and matambre (P = 0.01). A smaller rib eye area (REA) was observed in the CSL diet cuts, but a more intense luminosity was also observed in L* (P = 0.01) and b* (P = 0.02). Thus, the inclusion of 25% xerophyte hay in the diet of NDRS sheep was neither nutritionally nor economically favourable.
Comparative efficacy of titanium oxide nanoparticles and zinc oxide nanoparticles against lead tolerance, growth performance and nutrient profiling of Brassica Napus L. grown under Lead contaminated soil
Authors: Sehrish Adiba Khan , Ahmad Shoaib , Alomrani Sarah Owdah , Tabassam Rohina , Rahim Hafeez Ur , Ahmad Azeem , Tauqeer Arslan , Ali Shafaqat 
Published: January 2024

Abstract
The lead (Pb) has been regarded as toxic metal that negatively impact both plant growth and human health. Due to limited information available about the application of titanium dioxide (TiO2-NPs) and Zinc oxide nanoparticles (ZnO-NPs) for the alleviation of Pb stress in crop particularly in Brassica napus L. The current experiment was aimed to investigate the efficacy of foliar application TiO2 and ZnO-NPs on Pb uptake and growth performance. The results of our study demonstrated that TiO2 and ZnO-NPs foliar application at (25, 50 and 100 mg/L) significantly decreased Pb uptake and simultaneously improved plant growth attributes, including shoot and root length, shoot and root fresh weight. Additionally, the NPs foliar application significantly augmented plant photosynthetic pigment (chlorophyll a, chlorophyll b, total chlorophyll and carotenoids) and gas exchange parameters compared to control. The biochemical analysis showed increased in plant antioxidative enzymes activities (peroxidase, Catalase, Superoxide dismutase) and reduction in oxidative stress (malondialdehyde, hydrogen peroxide, electrolyte leakage) under Pb stress upon NPs application. Importantly, foliar application of 100mg/L significantly reduced the uptake and translocation of pb in plant root and shoot with 45.7% and 84.1% respectively, as compared to control without nanoparticles. Furthermore, foliar application of TiO2 and ZnO-NPs enhance shoot zinc (Zn), iron (Fe), manganese (Mn), magnesium (Mg) calcium (Ca) and Potassium (K) when compared to control without nanoparticles. Interestingly concentrations of macro and micro nutrients with the type and dose of nanoparticles were varied. The highest concentrations of Ca (69.8%), Mn (67.3%) and Zn (78.7%) were found at 100mg/L ZnO-NPs foliar application while, the highest concentrations of Fe (79.4%), Mg (72.1%) and K (81.4%) were observed at 100mg/L TiO2 -NPs. Overall, application of nanoparticles especially, TiO2- NPs for Brassica napus L. is promising strategy for sustainable agriculture towards alleviating Pb toxicity and ensuring food security.
Paper Mill Sludge as a Replacement for the Cellulosic Component of Hydroseed Mixtures
Authors: MacDonald-MacAulay Brittany Ann , Donaldson Adam , Walsh Margaret , Abbey Lord 
Published: January 2024

Abstract

Pulp and paper mill sludge is composed of cellulosic waste and clay, and rich in microorganisms that can benefit horticulture. However, its application in horticulture has received less research attention.Field and greenhouse studies were carried out to determine if sludge from a case study industry can replace the typical cellulosic additive utilized in hydroseeding, and the ideal application rate of a sludge-soil-seed mixture. The treatments were 0 - 100% sludge and soil by mass with a consistent mass of embedded seeds of Kentucky Bluegrass (Poa pratensis), Creeping Red Fescue (Festuca rubra), Perennial (Lolium perenne) and Annual Ryegrass (Lolium multiflorum). Seeding with a top layer of soil and 5 to 75% sludge gave the best outcome using a cellulosic additive after 3 weeks of growth. Mixtures containing 5- 25% sludge resulted in the quickest seed germination rate. The cellulosic additive has the capacity to retain a higher volume of water but requires 15 times more material by volume. An increase in sludge increased water retention by 20%. Overall, the cellulosic additive in hydroseeding applications can be replaced by sludge without plant detriment. However, further testing is needed to determine long-term effects.
Alkali metal cations: no more spectators, but homogeneous catalysts in aqueous electrolytes
Authors: Choi Chang Hyuck , Ji Sang Gu , Kim Minho , Han Man Ho , Cho Junsic , Son Yoosang , Kim Young Yong , Kim Zee Hwan , Chae Keun Hwa , Oh Hyung-Suk , Kim Hyungjun 
Published: January 2024

Abstract

Alkali metal cations (AM+) exhibit high solubility and ionic conductivity, making them optimal components in aqueous electrolytes. Despite the conventional belief that AM+ are chemically inert spectators, the strong dependence of electrocatalysis on AM+ has recently provoked debates about their unforeseen catalytic role. However, conclusive evidence is still lacking. Here we demonstrate that AM+ can couple with reaction intermediates and determine kinetics as homogeneous catalysts in aqueous conditions. In alkaline oxygen reduction on carbon, in situ X-ray absorption spectroscopy reveals a change in the electronic structure of Na+ from its hydrated state on a charged electrode. In situ Raman spectroscopy further identifies that this change is due to the formation of water-unstable NaO2 as a key intermediate in OOH− production. Together with theoretical calculations, this finding enunciates the counterintuitive catalytic role of AM+ in aqueous environments, highlighting the exigency of new interface design principles for better electrocatalysis.
Checkpoint inhibitor immunotherapy induced inflammatory arthritis secondary to Nivolumab and Ipilimumab: a pediatric first
Authors: Storwick John , Tam Herman , Rosenbaum Daniel , Houghton Kristin 
Published: January 2024

Abstract

Background
Immune checkpoint inhibitors (ICIs) have expanded the arsenal of cancer therapeutics over the last decade but are associated with a spectrum of immune-related adverse events (irAEs), including inflammatory arthritis. While these complications are increasingly recognized in the adult population, no cases of inflammatory arthritis irAEs have been reported in the pediatric literature.
Case Presentation
A 14-year-old female with metastatic epithelioid mesothelioma was referred to the pediatric rheumatology clinic after developing progressive inflammatory joint pain in her bilateral shoulders, hips, and small joints of hands following the second cycle of Nivolumab and Ipilimumab. Initial examinations showed bilateral shoulder joint line tenderness, positive FABERs test bilaterally, tenderness over bilateral greater trochanters, and bilateral second PIP effusions. Her serological profile was notable for positive HLA-B27, positive anti-CCP, negative Rheumatoid Factor, and negative ANA. PET-CT scan performed for disease response following immunotherapy showed symmetric increased metabolic activity primarily involving the supraspinatus, gluteus medius and minimus, and semimembranosus tendon insertions. Her presentation was consistent with a grade 1 irAE that worsened to a grade 2 irAE despite NSAID therapy, prompting a short course of oral prednisolone. She achieved clinical remission of her mesothelioma following six cycles of Nivolumab and Ipilimumab and her inflammatory arthritis was controlled on Celebrex monotherapy.
Conclusions
To our knowledge, this is the first pediatric case of ICI-induced inflammatory arthritis and enthesitis. This case highlights the importance of increasing awareness of diagnosis and management of irAEs in children.
Comparing the effects of argon plasma coagulation and interferon therapy in patients with vaginal intraepithelial neoplasia: a single-center retrospective study
Authors: Gao Yuan , Chu Weixin , Hou Lin , Cheng Junlan , Zhong Guyue , Xia Baoguo , Guo Li 
Published: January 2024

Abstract

Purpose This study aimed to evaluate the clinical efficacy and safety of argon plasma coagulation (APC) therapy and interferon therapy in patients with grade I and II vaginal intraepithelial neoplasia (VaIN).Methods A total of 112 patients with VaIN were diagnosed via colposcopy-induced biopsy and classified into the APC group (n = 77) and interferon group (n = 35). Clinical data including age, grade, symptoms, historical or concomitant neoplasia of the lower genital tract, indications for hysterectomy, pregnancy history, cytology, human papillomavirus (HPV) subtype, treatment modalities, and clinical outcomes were analyzed retrospectively. Complications and clinical outcomes were assessed at 6- and 12-month follow-ups.Results There was no significant difference in the HPV clearance rate between the APC (53.42%) and interferon (33.33%) groups at 6-month after treatment. However, the 12-month follow-up of the APC group showed a significantly higher HPV clearance rate as compared to the interferon group (87.67% vs. 51.52%, P < 0.05). The APC group exhibited a significantly higher cure rate (79.22% vs. 40.0%) and lower persistence rate ( 12.99% vs. 37.14%) than the interferon group (P < 0.05). Adverse reaction analysis revealed that the primary reaction in the APC group was vaginal drainage, in contrast to the increased vaginal discharge in the interferon group; though the difference was significant (68.83% vs. 28.57%, P < 0.05), no serious complications were observed.Conclusions Treatment with APC is a safe and more effective procedure against VaIN I and II, compared to interferon. APC may serve as a viable alternative to other physiotherapies.
Regional ice flow piracy following the collapse of Midgaard Glacier in Southeast Greenland
Authors: Huiban Flora , Millan Romain , Kjeldsen Kristian , Andresen Camilla S. , Doemgaard Mads , Dehecq Amaury , Brunt Stephen , Khan Shfaqat Abbas , Mouginot Jeremie , Bjørk Anders 
Published: January 2024

Abstract

The collapse of Midgaard Glacier in Southeast Greenland initiated a series of dynamic changes in neighbouring catchments. Understanding the evolution of this collapse, along with the numerous flow reorganizations that have transpired, is of paramount significance. This study delves into this extended retreat and drawdown since the end of the Little Ice Age, along with multiple flow reorganisations and their ripple effects on adjacent catchments. Here, we construct a comprehensive timeline, unveiling previously undisclosed complexities in glacial history. This is the first study documenting and investigating ice flow piracy and flow reorganisation in Greenland. We underscore the vital role of comprehending long-term ice dynamics, bed topography, ice-ocean interactions, and the significance of drainage basin piracy for precise predictions and models, especially in the context of climate change's impact on Greenland's ice sheet. The transformations witnessed at Midgard Glacier triggered both large (basin-wide) and local-scale dynamic shifts, affecting the flow direction of Glacier de France, and subsequently instigating dynamical adjustments within Pourquoi-Pas Glacier. This reinforces the imperative need for an interconnected basin approach when modelling dynamic changes on the ice sheet.
Universal control of four singlet-triplet qubits
Authors: Vandersypen Lieven , Zhang Xin , Morozova Elizaveta , Rimbach-Russ Maximilian , Jirovec Daniel , Hsiao Tzu-Kan , Fari$\tilde{\text{n}}$a Pablo Cova , Wang Chien-An , Oosterhout Stefan D. , Sammak Amir , Scappucci Giordano , Veldhorst Menno 
Published: January 2024

Abstract

The coherent control of interacting spins in semiconductor quantum dots is of strong interest for quantum information processing as well as for studying quantum magnetism from the bottom up. On paper, individual spin-spin couplings can be independently controlled through gate voltages, but nonlinearities and crosstalk introduce significant complexity that has slowed down progress in past years. Here, we present a 2×4 germanium quantum dot array with full and controllable interactions between nearest-neighbor spins. As a demonstration of the level of control, we define four singlet-triplet qubits in this system and show two-axis single-qubit control of each qubit and SWAP-style two-qubit gates between all neighbouring qubit pairs. Combining these operations, we experimentally implement a circuit designed to generate and distribute entanglement across the array. These results highlight the potential of singlet-triplet qubits as a competing platform for quantum computing and indicate that scaling up the control of quantum dot spins in extended bilinear arrays can be feasible.
Amitriptyline Ameliorates Arthritis by Downregulation of Inflammatory Mediators and Oxidative Stress; A
Mechanistic Approach
Authors: Ahsan Haseeb , Kauser Rizwana , Irfan Hafiz Muhammad , Haider Ihtisham , Ahsan Asma , Hassan Syed Shams ul , Bungau Simona , Anjum irfan 
Published: January 2024

Abstract
This study was designed to evaluate the antioxidant and anti-arthritic potential of amitriptyline. The albumin and formaldehyde were used to induce acute and chronic inflammation respectively. The adjuvant-induced arthritis model was developed in rats. In acute model, amitriptyline significantly (p < 0.001) decreased the thickness of paw at early as well as late stages. At high dose of test drug, the significant (p < 0.001) anti-arthritic effect was noted in formaldehyde-induced arthritic model. Likewise, Amitriptyline (40 mg/kg oral dose) produced a 4.7% decrease in swelling of paw prompted by CFA on day 14 that increased to17.09% on day 28. This effect significantly increased by higher dose of Amitriptyline 80 mg/kg (28.63%) on day 28th. The significant (p < 0.001) expression of antioxidant enzyme SOD (super oxide dismutase) was observed at maximum dose (80 mg/kg). Amitriptyline significantly reduced the levels of inflammatory cytokines like prostaglandin E2, TNF-α and NF-kB and the results were comparable with naproxen. Further, in-depth molecular docking and simulations studies of amitriptyline showed that it has good binding capacity with inflammatory cytokines showing the highest score with prostaglandin E2. In addition, ADMET studies also proved amitriptyline within the limits of Lipinski’s rule of five. These findings validate the anti-arthritic effect of amitriptyline, but it has limitations for clinical studies.
Dual-layer Spectral Detector CT in Predicting Benign and Malignant Laryngeal Tumors
Authors: Wang Fang , Zhang Danping , Zhang Xiaodi , Dai Guidong 
Published: January 2024

Abstract
Objectives: To investigate the quantitative parameters of dual-layer spectral detector CT in the assessment of benign and malignant laryngeal tumors.
Methods: Spectral images of 47 patients were retrospectively analyzed in both the arterial phase (AP) and the venous phase (VP), including 26 larynx squamous carcinoma (LSCC) lesions and 28 benign lesions. For the 54 lesions in the AP and VP, the slope of the spectral curve (λHUa and λHUv) from 40keV to 90keV, CT values of conventional images (CTa and CTv), iodine concentrations (ICa and ICv), normalized IC (NICa and NICv), effective atomic number (Zeff-a and Zeff-v), and normalized Zeff (nZeff-a and nZeff-v) were calculated and analyzed between LSCC and benign patients. ROC curve, independent sample t-test, and Spearman rank-sum test were used in statistical analysis.
Results: λHUv40-60keV had the highest diagnostic efficiency in all slope of the spectral curve. So λHU40-60keV was the best slope. All parameters in AP didn’t have well identifying efficiency. But all parameters in VP had perfect identifying efficiency. Especially the ICv was the highest, which sensitivity and specificity were 88.5% and 85.7%. All measured quantitative parameters except CTa and nZeff-a of AP were statistically significant difference between LSCC and benign laryngeal tumors. In the AP, quantitative parameters were weakly positively correlated with two kinds of tumors, especially CTa. But five quantitative parameters ( λHUv40-60keV,CTv,ICv, NICv, Zeff-v) were strongly positively in the VP,which the r values are 0.734, 0.696, 0.748, 0.691, 0.730 respectively.
Mutations Detected in Real World Clinical Sequencing during BTK Inhibitor Treatment in CLL
Authors: Brown Jennifer , Mashima Kiyomi , Fernandes Stacey , Naeem Aishath , Shupe Samantha , Fardoun Rayan , Davids Matthew 
Published: January 2024

Abstract
We retrospectively analyzed 609 chronic lymphocytic leukemia (CLL) patients treated with BTK inhibitors (BTKis) at Dana-Farber Cancer Institute from 2014 to 2022. Among them, 85 underwent next-generation sequencing (NGS) during or after BTKi therapy (ibrutinib, 64; acalabrutinib, 13; pirtobrutinib, 7; vecabrutinib, 1). Patients with NGS at progression (N=36, PD group) showed more 17p deletion, complex karyotype, and previous treatments including BTKi, compared to ongoing responders (N=49, NP group). 216 variants were found in 57 genes across both groups, with more variants in the PD group (158 variants, 70.3% pathogenic, P<0.001). The PD group had a higher incidence of pathogenic variants (70.3%, P<0.001), including 32 BTK (BTK C481S/F/R/Y, L528W, and T474I/L) and 4 PLCG2mutations. Notably, a high VAF L528W mutation was found in a first line ibrutinib-resistant patient. TP53, SF3B1, and NOTCH2mutations were also significantly more prevalent in the PD group (P<0.01, P<0.05, P<0.05). Additionally, MAPK pathway gene mutations trended more common and had higher VAFs in the PD group (P=0.041). T474 mutations were found in 4 of 6 patients progressing on pirtobrutinib, and BTK L528W mutation can arise with both covalent and non-covalent BTKi therapy. These results also suggest that RAS/RAF/MAPK pathway mutations may contribute to BTKi resistance.