bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the Timeliness of EMR Documentation in Resident Doctors: The Role of PDCA Cycle Management
Authors: Chen Jiaoting , Zhang Qiongwen 
Published: January 2024

Abstract

Background
The role of the Plan-Do-Check-Act (PDCA) cycle in managing the timeliness of electronic medical records (EMRs) remains unclear. Therefore, this study aimed to evaluate the effect of PDCA management in improving the timeliness of EMR for resident doctors.
Method
This study had a before and after design. The resident doctors rotating in the Head and Neck Oncology Department of West China Hospital, Sichuan University from November 2021 to August 2022 were classified as the control group, which was managed by the current department practice. The resident doctors from September 2022 to June 2023 were included in the PDCA group, which was managed by the PDCA cycle. The incidences of late EMRs and unqualified EMRs were compared between the two groups and the influencing factors of the occurrence of late EMRs and unqualified EMRs were explored.
Results
A total of 314 resident doctors were included, with 162 doctors in the PDCA group and 152 doctors in the control group. The incidences of late EMRs (5.40% vs. 2.56%, P = 0.005) and unqualified EMRs (1.05% vs. 0.00%, P < 0.001) in the PDCA group were significantly lower than those in the control group. The timeliness of the first disease course records (0.24% vs. 0.00%, P = 0.023) and the first-ward-round records (0.36% vs. 0.00%, P = 0.035) were also improved significantly. After incorporating confounding factors, including age, sex, academic degree, working hours, and major, PDCA management still significantly reduced the occurrence of unqualified EMRs (P < 0.001) with an adjusted OR of 0.166 (95% CI 0.067–0.416) and a probability of 83.4% (0.166–1 = − 0.834).
Conclusion
This study successfully developed PDCA management and revealed that it is beneficial to enhance the timeliness of EMR while concurrently reducing the incidence of unqualified or delayed entries among resident doctors.
Chaotic games driven grey wolf optimization: optimal performance design and comprehensive analysis
Authors: Tang Chenhua , Huang Changcheng , Chen Yi , Heidari Ali Asghar , Chen Huiling , Liang Guoxi 
Published: January 2024

Abstract

Introduction
: Meta-heuristics have attracted much attention due to their compatibility with other algorithms and excellent optimization ability. Gray wolf optimization (GWO) is also a meta-heuristic algorithm. GWO mainly tries to find the optimal solution by simulating the hierarchical structure and hunting behavior of gray wolves. GWO has the advantages of a relatively simple algorithm structure and fewer parameter Settings. Therefore, it is used in many fields, such as engineering and forecasting.
Objectives
GWO may have problems in harmonic convergence or be trapped into local optima for some complex tasks. An improved variant of basic GWO is proposed in this paper to efficiently alleviate this deficiency. Preferentially, chaos game optimization (CGO) is introduced into the conventional method to expand its neighborhood searching capabilities. Based on this strategy, we called the improved GWO as CGGWO.
Methods
To confirm the effectiveness and optimization ability of the CGGWO algorithm, CGGWO is compared with a set of meta-heuristics, including 7 basic meta-heuristics, 7 state-of-the-art meta-heuristics, and 5 enhanced GWO variants. The benchmark functions for comparison are IEEE CEC 2017. The dimensions(D) of the benchmark test function are 10, 30, 50, and 100. Moreover, CGGWO is applied to five practical engineering problems and two real-world benchmarks from IEEE CEC 2011. Non-parametric statistical Wilcoxon signed-rank and the Friedman tests are performed to monitor the performance of the proposed method.
Results
In benchmark function testing, CGGWO can find better solutions in most functions. In the Wilcoxon signed-rank and the Friedman tests, the P-value of CGGWO is mostly less than 5%. Among the five engineering problems, the feasible solution found by CGGWO is also the best compared with other methods.
Conclusions
In the benchmark function test, CGGWO has a better convergence effect than other methods and finds a better solution. From the results of the Wilcoxon signed-rank and the Friedman tests, we can see that the CGGWO results are statistically significant. In engineering problems, CGGWO can find feasible solutions.
Portfolio Sorting by Leverage Ratio and Validation in American Stock Market
Authors: Rong Runsheng 
Published: January 2024

Abstract

The stock market has high risks. The purpose of this project is to sort five different portfolios from all stocks in S&P 500 by the leverage ratio, then perform both time-series and cross-sectional regression on each of the portfolios to find anomalies of pricing, also test whether to choose risk-premium or hedging strategy, and finally build both an out-performing strategy and a long-short strategy. Putting more stocks into the portfolio can help analysts carry out comprehensive analysis on different situations, periods, and types of investment portfolio, so as to disperse risks, in order to ensure the diversity of portfolio and a lower risk.
Pressure Ulcer And Associated Factors Among Adult Patients Admitted To The Surgical Wards In The Comprehensive Specialised Hospital Of The Northwest Amhara Regional State, Ethiopia
Authors: Bekele Habtamu , Zemene Workie , Tesfaye Eleny 
Published: January 2024

Abstract
Background
A pressure ulcer is is a serious concern for prolonged bed patient and presents common complication following surgery. It is one of key performance indicators of nursing quality of care provided to the patient.Even though some studies reported the prevalence of pressure ulcer in Ethiopia. There is a lack of evidence in the current study area regarding its prevalence and the factors associated with it. The main objective of th is study was to assess pressure ulcer and associated factors among adult patients admitted to the surgical ward in Amhara Regional Comprehensive Specialized Hospital in Northwest Ethiopia,2023.
Method
An institution-based, cross-sectional study was conducted from Junary 15 to June 19 ,2023 at North West Ethiopia.A systematic random sampling technique was used to select 480 patients. Descriptive data was presented as absolute number with percentage, and multivariate analysis was used to assess the statistical association between a ssociated factors and pressure ulcer. A Pvalue of < 0.05 was considered as statistical significant.
Results
A total of 49 pressure ulcer cases were detected among 480 patients.With a prevalence rate of 10.2%, 95% CI (7.7, 12.9). Participants who had smoked (95% CI: AOR 7.46 (2.64,21.06), being bedridden (95% CI: AOR 3.92 (1.28, 11.66), had 21days the length of hospital stay (95% CI: AOR 3.01 (1.13, 8.02), had pain (95% CI: AOR 3.20 (1.06, 7.51), and had friction and shear (95% CI: AOR 5.71 (1.91, 17.08), were significant factors associated with pressure ulcer.
Conclusion
This study showed a high percentage of pressure ulcer among patients .Smoking status, patients with pain, the patient's bedridden condition, patients with problems of friction and shear, and length of hospital stay were significantly associated with pressure ulcer. Healthcare providers should educate patients on smoking risks, pain management, mattress installation, and linen care.
Investigating the vulnerability of the northern coasts of Iran due to changes in the water level of the Caspian Sea by considering the effects of climate change
Authors: Ghassabian Sina , Tayari Omid , Momeni Roghabadi Mehdi , Irandoost Mohsen 
Published: January 2024

Abstract
Coastal aquifers are one of the most important sources of water supply, and it is expected that the effects of climate change will be one of their threatening factors in the short or long term. The present study was conducted in the northern coasts of Iran (Amirabad, Babolsar) and the main goal was to investigate the behavior of saltwater advance in coastal aquifers considering the changes in the coastline due to the effects of climate change and aquifer characteristics. In order to simulate the flow of underground water and the advancement of salt water in the coastal aquifer of the Caspian Sea, MODFLOW MT3DMS and SEAWAT numerical models were used in the GMS10.6 software. The results show that there is a salinity increase of up to 60 ppt, which is much higher than the minimum seawater salinity of 2 ppt. According to the results, it is clear that in the studied area, contaminated water entered the underground aquifers, especially in the coastal erosion areas and during the seasons when the sea level changes and when the changes in the coastline increase.
Modeling and optimization of engineering parameters for the treatment of textile wastewater using modified clay/TiO2/ZnO
Authors: Jamil Tayyaba 
Published: January 2024

Abstract

The objective of this project was to develop a new hybrid nanocomposite that would maximize chemical oxygen demand (COD) and color removal from effluent from the actual textile industry to overcome the water crisis brought on by increasing industrialization and urbanization. This study is the first to use modified clay/TiO2/ZnO nanocomposites for adsorbing actual textile wastewater treatment. The adsorption capacity from the dye removal was evaluated to optimize the three engineering parameters (pH, adsorbent dose, and time) utilizing response surface methodology. An isotherm kinetic intra-particle diffusion model was developed to study the sorption phenomena. The best fit for sorption was provided by Langmuir isotherms, with an R2 of better than 0.99. The sorption process follows the pseudo-second-order kinetics that favors chemisorption, following kinetic theory. The sorption process is endothermic, viable, and spontaneous in nature, according to a thermodynamic study. At the optimal pH (5.5), adsorbent dose (0.55 g), and time (75 min), the maximum COD and color removal were achieved to be 94 and 91% with a maximum sorption capacity of 660 mg/g. In this optimization, the adj. R2 and R2 correlation coefficients were calculated as 0.7213 and 0.7653, respectively. The hybrid composite seems to be effective for treating real effluents.
The Impact of miR-122 on Cancer
Authors: Wu Shijie , Wu Yiwen , Deng Sijun , Lei Xiaoyong , Yang Xiaoyan 
Published: January 2024

Abstract:
MiRNAs are confirmed to be a kind of short and eminently conserved noncoding
RNAs, which regulate gene expression at the post-transcriptional level via binding to the 3'-
untranslated region (3’-UTR) of targeting multiple target messenger RNAs. Recently, growing
evidence stresses the point that they play a crucial role in a variety of pathological processes,
including human cancers. Dysregulated miRNAs act as oncogenes or tumor suppressor genes in
many cancer types. Among them, we noticed that miR-122 has been widely reported to significantly
influence carcinogenicity in a variety of tumors by regulating target genes and signaling
pathways. Here, we focused on the expression of miR-122 in regulatory mechanisms and tumor
biological processes. We also discussed the effects of miR-122 dysregulation in various types of
human malignancies and the potential to develop new molecular miR-122-targeted therapies.
The present review suggests that miR-122 may be a potentially useful cancer diagnosis and
treatment biomarker. More clinical diagnoses need to be further launched in the future. A promising
direction to improve the outcomes for cancer patients will likely combine miR-122 with
other traditional tumor biomarkers.
Enhanced Sampling in Molecular Dynamics Simulations: How Many MD
Snapshots can be Needed to Reproduce the Biological Behavior?
Authors: Tavares Camila A. , Santos Taináh M.R. , Gonçalves Mateus A. , da Cunha Elaine F.F. , Ramalho Teodorico C. 
Published: January 2024

Abstract:
Since its early days in the 19th century, medicinal chemistry has concentrated its efforts
on the treatment of diseases, using tools from areas such as chemistry, pharmacology, and molecular
biology. The understanding of biological mechanisms and signaling pathways is crucial information
for the development of potential agents for the treatment of diseases mainly because they are such
complex processes. Given the limitations that the experimental approach presents, computational
chemistry is a valuable alternative for the study of these systems and their behavior. Thus, classical
molecular dynamics, based on Newton's laws, is considered a technique of great accuracy, when
appropriated force fields are used, and provides satisfactory contributions to the scientific community.
However, as many configurations are generated in a large MD simulation, methods such as Statistical
Inefficiency and Optimal Wavelet Signal Compression Algorithm are great tools that can
reduce the number of subsequent QM calculations. Accordingly, this review aims to briefly discuss
the importance and relevance of medicinal chemistry allied to computational chemistry as well as to
present a case study where, through a molecular dynamics simulation of AMPK protein (50 ns) and
explicit solvent (TIP3P model), a minimum number of snapshots necessary to describe the oscillation
profile of the protein behavior was proposed. For this purpose, the RMSD calculation, together
with the sophisticated OWSCA method was used to propose the minimum number of snapshots.
Ovothiol-A Mitigates High-Fat Diet-Induced Non-alcoholic Fatty Liver
Disease in Rats
Authors: Arafa Nada Hussien , Shehata Mohamed Refaat , Mohamed Ayman Saber 
Published: January 2024

Background:
Obesity is frequently linked to multiple comorbid and chronic illnesses,
including non-alcoholic fatty liver disease, type 2 diabetes, cancer, and heart disease. Ovothiol-A
is one of the most powerful natural antioxidants found in marine invertebrates like sea urchins.

Objective:
The current study aimed to investigate ovothiol-A's hypolipidemic and hypoglycemic
potential in obese rats.

Methods:
All groups get a high-fat diet (HFD) for four weeks except for the control group. The
control and HFD groups received distilled water, while the Ovothiol-A groups received two doses
of Ovothiol-A (200 and 400 mg/kg orally) concurrent with HFD.

Results:
Weight gain, glucose, insulin, alanine aminotransferase, aspartate aminotransferase,
gamma-glutamyl transferase, alkaline phosphatase, total cholesterol, triglycerides, low-density
lipoprotein, malondialdehyde, and nitric oxide were all decreased after oral administration of Ovo
at either the 200 or 400 mg/kg dose, while levels of high-density lipoprotein (HDL), glutathionereduced, catalase and glutathione-S-transferase increased. Histopathological alterations were less
noticeable in the liver tissue of Ovothiol-A groups, with only a few vacuolated or pyknotic nuclei
amongst a few dispersed hepatocytes.

Conclusion:
The current findings indicate that ovothiol-A protects against high-fat diet-induced
fatty liver in rats. The anti-obesity mechanism of Ovothiol-A is associated with its hypolipidemic,
hypoglycemic, and antioxidant properties.
Formulation and Evaluation of Glipizide-loaded Mucoadhesive Microparticle
Using Salvia hispanica Seeds Mucilage as Co-polymer
Authors: Ojha Smriti , Tripathi Stuti , Tripathi Shivendra  Mani , Mishra Sudhanshu 
Published: January 2024

Aims:
Chia seed (Salvia hispanica L.) gum is a mucoadhesive, biodegradable polymer
with sustained release properties.

Objective:
The objective of this study was to compare different formulations of glipizide-loaded
microparticles using chia seed mucilage and sodium alginate, focusing on sustained release and
mucoadhesive properties.

Background:
The present study aimed to comparatively evaluate various eco-friendly
formulations of glipizide-loaded microparticles prepared using chia seed mucilage and sodium
alginate.

Materials and Methods:
Gum was extracted from chia seeds and lyophilized, and preformulation studies were performed according to established protocols. Microparticles were
formulated using the ionic gelation method, with sodium alginate as a copolymer and zinc
chloride as a cross-linking agent. The prepared microparticles were evaluated using scanning
electron microscopy (SEM) for size and particle aggregation, and Fourier Transform infrared
spectroscopy (FTIR) for drug-polymer interaction, entrapment efficiency, swelling index, and in
vitro drug release.

Results:
The % yield of chia seed mucilage was 27.35%. The pH of the mucilaginous suspension
was 4.67 ± 0.50. The moisture content value was 14.56 % ± 0.50. The values of Carr's index and
Hausner's ratio were 22.58 ± 1.89 and 1.38 ± 0.05, respectively. FTIR spectra showed no
interaction between pure glipizide and chia seed mucilage, confirming no possible change in
glipizide's pharmacology. SEM studies have confirmed the shape of the microparticles to be
spherical, with average sizes ranging from 1235.18 ± 8.7 to 1423.25 ± 9.5 µm, and the drug
entrapment efficiency ranged from 64.25 ± 2.52 to 81.82 ± 7.56%. The release of glipizide from
the microparticles was sustained, and the Higuchi and Korsmeyer-Peppas models were found to
be the best-fit kinetic models.

Conclusion:
The promising copolymer blend of chia seed mucilage and sodium alginate was
used for the development of sustained-release dosage forms. A copolymer blend with a ratio of
1:1 produced glipizide-loaded microparticles with sustained release profiles and good
mucoadhesive ability, along with a high percentage of drug entrapment efficiency.
Sulbactam-Durlobactam, A Novel Drug for the Treatment of Multidrug
Resistant Acinetobacter baumannii Infections - A Systematic Review
Authors: Velmurugan Hemasri , Venkatesan Sajitha , Meles Hadush Negash , Neelambaram Krishnapriya , Thangaraju Pugazhenthan 
Published: January 2024

Background:
Sulbactam-durlobactam (SUL-DUR) has been tested in vitro for its ability to gen-
erate resistance in clinical isolates of Acinetobacter species. According to prior studies, combining durlobac-
tam with sulbactam causes sulbactam-resistant isolates to become more active and revert to susceptibility.
We aimed to conduct a systematic review of the in vitro activity of SUL-DUR on A. baumannii (Ab) iso-
lates, including carbapenem-resistant A. baumannii (CRAb), to provide an overview for physicians dealing
with Ab infections.

Methods:
The following keywords were searched in the PubMed, Google Scholar, and EMBASE databases
to look for eligible original works that have been published without restrictions till June 30, 2023: A. bau-
mannii and sulbactam-durlobactam, SUL-DUR, durlobactam, and sulbactam-ETX2514. We also searched
clinicaltrials.gov and the Clinical Trials Registry of India (CTRI) for clinical trials involving sulbactam-
durlobactam and Acinetobacter

Results:
There were a total of 852 abstracts found. Among them, 633 articles with titles, abstracts, and key-
words were reviewed, and 574 articles were removed after the initial screening. A total of 59 full-text eligi-
ble articles were evaluated, and 51 of them were eliminated because they did not satisfy the criteria set for
inclusion. The full texts of the final 8 in vitro studies on A. baumanii and sulbactam/durlobactam were fur-
ther evaluated. There were 5 trials on A. baumanii and sulbactam/durlobactam found on clinicaltrials.gov
and the Clinical Trial Registry of India (CTRI).

Conclusion:
The findings from the studies show that SUL-DUR might be a successful therapeutic option for
multidrug-resistant-Ab infections. Future clinical trials will be required to validate the possibility of using
this combination to treat multidrug-resistant A. baumannii infections.
Exosome and Other Extracellular Vesicles in Gene Therapy and
Personalized Care
Authors: Minocha Neha , Sardana Satish 
Published: January 2024

Abstract:
Exosomes and other extracellular vesicles (EVs) have emerged as versatile
agents facilitating cell-to-cell communication, assuming pivotal roles in both physiological and pathological contexts. This manuscript presents an extensive overview of the existing knowledge concerning the utilization of exosomes and EVs in gene therapy and
personalized healthcare. It delves into their inherent capacity for transferring genetic material, their limited immunogenicity, and their potential for precise and targeted delivery.
Furthermore, the paper investigates the ever-evolving domain of biomarker discovery,
where exosomes and EVs hold substantial promise for the early detection of diseases and
the monitoring of treatment responses. As ongoing research advances, the manuscript explores the potential for refining protocols related to standardization and quality control,
along with the optimization of scalable manufacturing methods. Additionally, the manuscript sheds light on the burgeoning potential for individualized treatments driven by genomic profiling. By examining these facets, we foresee that exosomes and EVs will play
a pioneering role in ushering in a new era of precision medicine, offering safer, more efficacious, and highly customized therapeutic interventions across a spectrum of medical
conditions.
Therapeutic Potential and Clinical Effectiveness of Quercetin: A Dietary
Supplement
Authors: Devi Vishakha , Deswal Geeta , Dass Rameshwar , Chopra Bhawna , Kriplani Priyanka , Grewal Ajmer Singh , Guarve Kumar , Dhingra Ashwani K. 
Published: January 2024

Abstract:
Fruits and vegetables (like apples, citrus, grapes, onions, parsley, etc.) are the
primary dietary sources of quercetin. In addition, isolated quercetin is also available on the
market as a dietary supplement with a daily dose of up to 1000 mg/d. The objective of the
present study is to explore the therapeutic potential and clinical efficacy of quercetin as a dietary
supplement. The present paper highlights the safety parameters and clinical trial studies
with several targets reviewed from the data available on PubMed, Science Direct, ClinicalTrails.
gov, and from many reputed foundations. The results of the studies prove the
unique position of quercetin in the treatment of various disorders and the possibility of using
phytochemicals such as quercetin for an efficient cure. As evidenced by the numerous published
reports on human interventions, it has been concluded that quercetin intake significantly
improves disease conditions with minimal adverse effects.