bluuebunny/crossref_metadata_2025_split huggingface dataset:
One Intravitreal Dexamethasone Implant versus Multiple Intravitreal Injections of Triamcinolone Acetonide for Post-Surgical Macular Edema: Efficacy and Safety
Authors: Jalkh Edmond , Doumit Carla Abi , Schakal Alexandre , Samaha Ameed , Nehme Joseph , Raad Philip , Salameh Marina Rached , Jalkh Alex 
Published: January 2024

Abstract

Purpose: The aim of the study is to compare the efficacy and safety of one or multiple intravitreal triamcinolone acetonide (ITA) injections to a single intravitreal dexamethasone implant (IDI) in the treatment of post-surgical cystoid macular edema (CME).
Methods: A retrospective study was conducted on 99 consecutive eyes between January 2019 and January 2022. Sixty five of 99 eyes (65.7%) received ITA and 34 of 99 eyes (34.3%) received IDI. The anatomical and functional results were based on best corrected visual acuity (BCVA) and central retinal thickness (CRT) with a follow up period of 6 months. Also post-injection complications were studied, particularly increase in intraocular pressure (IOP) and cataract progression in phakic eyes.
Results: BCVA improved in 84 of 99 eyes (85%), 53 of 65 eyes (82%) in the ITA group and 31 of 34 eyes (91%) in the IDI group, and the difference between both groups was not significant (p=0.058).
CRT improved in 89 of 99 eyes (90%), 57 of 65 eyes in the ITA group (88%) and 32 of 34 eyes (94%) in the IDI group, and the difference between both groups was not significant (P=0.074).
Fifteen of 65 eyes (23%) in the ITA group and 7 of 34 eyes (21%) in the IDI group had increased IOP. There was no significant difference between the two groups (P=0.627). Cataract progression occurred in 1 of 4 phakic eyes (25%) in the ITA group, while none occurred in the IDI group (P=0.214).
Conclusion: At the final follow-up, no significant difference was observed between both the ITA and the IDI groups in terms of BCVA, CRT, and increase in IOP.
Analysing the Bitcoin Growth Pattern amid Financial Instability and the Health Crisis in the MENA Region: A Spatial Cartographic Distribution Study
Authors: MTIRAOUI Abderraouf Ahmed , ALIOUET Slim 
Published: January 2024

Abstract
The objective of this paper is to conduct a spatial distribution mapping study. Within this framework, we aim to illustrate, through a spatial distribution mapping of the MENA region, the mobilization and variation of Bitcoin during the period of the health crisis in the presence of political instability. This work contextualizes, on the one hand, the theoretical foundations, especially drawing on the works of Waelbroek (2017) and Bidan & Parrein (2018). On the other hand, it builds upon previous empirical studies through the analysis of the emblematic case of Big Block Data centers within the Bitcoin ecosystem. The research employs a methodology focused on spatial mapping for a comprehensive analysis.
JEL Classification : C55, E66, C22.
Therapeutic Role of HAT Therapy in Sepsis: A Systematic Review and Meta-Analysis
Authors: Saghafi Fatemeh , Boostani Moghadam Zahra , Salehi-Abargouei Amin , Beigrezaei Sara , Sohrevardi Seyed Mojtaba , Jamialahmadi Tannaz , Sahebnasagh Adeleh , Sahebkar Amirhossein 
Published: January 2024

Background:
This systematic review and meta-analysis aimed to determine whether
the combination of hydrocortisone, vitamin C (ascorbic acid), and thiamine (HAT therapy) diminishes
the mortality and is effective in expediting the resolution of sepsis and septic shock or not.

Methods:
The following databases of PubMed, Scopus, ISI Web of Science, and Google Scholar
were explored until March 2021 for all existing literature related to this field. An automatic alert
for all databases was also activated to update our search. Meta-analysis was performed on clinical
trials and cohorts separately as well as on all the pooled populations.

Results:
This study evaluated nine clinical trials (1358 participants) and nine cohorts (339,437 participants)
and is the most comprehensive systematic review in this field. The results of our meta-analysis
demonstrated a significant difference in the reduction of Sepsis-Related Organ Failure Assessment
(SOFA) score changes (Δ-SOFA) over 72 h (Standard Mean Difference (SMD) =
−0.429; 95% CI: −0.737, 0.120; P = 0.006), duration of vasopressor (VP) (SMD = −0.373; 95%
CI: −0.619, −0.128; P = 0.003), and procalcitonin (PCT) clearance (SMD = 0.496; 95% CI: 0.061,
0.931%; P = 0.026). Considering the results of cohorts, HAT therapy was effective in the survival
of intensive care units (ICUs) patients (OR = 0.641; 95% CI: 0.423-0.970, P = 0.035). However,
no significant difference was observed between the intervention and control groups in hospital
mortality (Odds Ratio (OR) = 0.811, 95% CI: 0.544-1.209, P = 0.304), 28- to 30-day mortality
(OR = 1.000; 95% CI: 0.782-1.279, P = 0.998), new onset acute kidney injury requiring renal replacement
therapy ((OR = 0.856, 95% CI: 0.526, 1.391; P = 0.529), in-hospital length of stay
(LOS) (SMD = 0.090; 95% CI: −0.036, 0.216 days; P = 0.162), LOS in ICU (SMD = 0.016, 95%
CI: −0.138, 0.170 days; P = 0.838), and mechanical ventilation-free days (SMD = 0.004; 95% CI:
−0.154, 0.163 days; P = 0.956).

Conclusion:
Supplementation of septic and septic shock patients with HAT therapy has significant
beneficial effects on SOFA score over 72 hours, duration of exogenous vasopressor infusion
and procalcitonin clearance. Considering the results of cohort studies, supplementation with HAT
is efficacious in reducing ICU mortality.
CBX8 Promotes Epithelial-mesenchymal Transition, Migration, and
Invasion of Lung Cancer through Wnt/β-catenin Signaling Pathway
Authors: Cai Xiaoping , Lv Yuankai , Pan Jiongwei , Cao Zhuo , Zhang Junzhi , Li Yuling , Zheng Hao 
Published: January 2024

Background:
Lung cancer (LC) is primarily responsible for cancer-related deaths
worldwide. Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features and is associated with the development of tumors. CBX8, a member of the
PcG protein family, plays a critical role in various cancers, containing LC. However, specific regulatory
mechanisms of CBX8 in LC progression are not fully understood. This study aimed to investigate
the regulatory role of CBX8 in LC progression.

Methods:
Bioinformatics was used to analyze the relationship between CBX8 level and tumor and
the enrichment pathway of CBX8 enrichment. qRT-PCR was used to detect the differential expression
of CBX8 in LC cells and normal lung epithelial cells. The effects of knockdown or overexpression
of CBX8 on the proliferation, migration and invasion of LC cells were evaluated by CCK-
-8 assay and Transwell assay, and the levels of proteins associated with the EMT pathway and Wnt/
β-catenin signaling pathway were detected by western blot.

Results:
Bioinformatics analysis revealed that CBX8 was highly expressed in LC and enriched on
the Wnt/β-catenin signaling pathway. The expression level of CBX8 was significantly elevated in
LC cells. Knockdown of CBX8 significantly inhibited cell proliferation, migration and invasion,
and decreased the expression levels of EMT-related proteins and Wnt/β-catenin pathway-related
proteins. Conversely, overexpression of CBX8 promoted cell proliferation, migration and invasion,
and increased the expression levels of EMT-related proteins and Wnt/β-catenin pathway-related
proteins. The Wnt inhibitor IWP-4 alleviated the effects produced by overexpression of
CBX8.

Conclusion:
Collectively, these data demonstrated that CBX8 induced EMT through Wnt/β--
catenin signaling, driving migration and invasion of LC cells.
Synthesis, Characterization, and Optimization of Novel Furan-ring Fused
Chalcones via Radical Cyclization of α,β-Unsaturated Ketones and Cyclic
Ketone
Authors: Burgaz Emine Vildan , Noshadi Bahareh , Yakut Mehtap 
Published: January 2024

Abstract:
Novel Furan-ring Fused Chalcones (FFC) were synthesized using a radical cyclization reaction
of α,β-unsaturated ketones with cyclic ketone as the model reaction to attain this goal. In this study,
traditional and microwave-assisted methods for the efficient and cost-effective synthesis of furan-ring
fused chalcones in mild reaction conditions are compared and optimized. The goal is to develop a reliable
and adaptable synthetic technique that may be used to produce these useful chalcone derivatives
quickly and effectively. The optimal experimental conditions for these reactions were carefully determined
using two independent methodologies: conventional (Method A) and microwave (Method B).
The results indicated that the proposed method B could be used effectively in the future to synthesize
novel furans with short reaction times and acceptable yields (87-94 %), and products were purified by
column chromatography and preparative thin layer chromatography (PTLC). All new compounds were
characterized by 1H-NMR, 13C-NMR, LC-MS, and elemental analyses.
A Review of Antidiabetic Medicinal Plants as a Novel Source of
Phosphodiesterase Inhibitors: Future Perspective of New Challenges
Against Diabetes Mellitus
Authors: Ouassou Hayat , Elhouda Daoudi Nour , Bouknana Saliha , Abdnim Rhizlan , Bnouham Mohamed 
Published: January 2024

Abstract:
Intracellular glucose concentration plays a crucial role in initiating the molecular secretory
process of pancreatic β-cells through multiple messengers and signaling pathways. Cyclic nucleotides
are key physiological regulators that modulate pathway interactions in β -cells. An increase
of cyclic nucleotides is controled by hydrolysed phosphodiesterases (PDEs), which degrades
cyclic nucleotides into inactive metabolites. Despite the undeniable therapeutic potential of PDE
inhibitors, they are associated with several side effects. The treatment strategy for diabetes based on
PDE inhibitors has been proposed for a long time. Hence, the world of natural antidiabetic medicinal
plants represents an ideal source of phosphodiesterase inhibitors as a new strategy for developing
novel agents to treat diabetes mellitus. This review highlights medicinal plants traditionally
used in the treatment of diabetes mellitus that have been proven to have inhibitory effects on PDE
activity. The contents of this review were sourced from electronic databases, including Science
Direct, PubMed, Springer Link, Web of Science, Scopus, Wiley Online, Scifinder and Google
Scholar. These databases were consulted to collect information without any limitation date. After
comprehensive literature screening, this paper identified 27 medicinal plants that have been reported
to exhibit anti-phosphodiesterase activities. The selection of these plants was based on their
traditional uses in the treatment of diabetes mellitus. The review emphasizes the antiphosphodiesterase
properties of 31 bioactive components derived from these plant extracts. Many
phenolic compounds have been identified as PDE inhibitors: Brazilin, mesozygin, artonin I, chalcomaracin,
norartocarpetin, moracin L, moracin M, moracin C, curcumin, gallic acid, caffeic acid,
rutin, quercitrin, quercetin, catechin, kaempferol, chlorogenic acid, and ellagic acid. Moreover,
smome lignans have reported as PDE inhibitors: (+)-Medioresinol di-O-β-d-glucopyranoside, (+)-
Pinoresinol di-O-β-d-glucopyranoside, (+)-Pinoresinol-4-O-β-d-glucopyranosyl (1→6)-β-dglucopyranoside,
Liriodendrin, (+)-Pinoresinol 4′-O-β-d-glucopyranoside, and forsythin. This review
provides a promising starting point of medicinal plants, which could be further studied for the
development of natural phosphodiesterase inhibitors to treat diabetes mellitus. Therefore, it is important
to consider clinical studies for the identification of new targets for the treatment of diabetes.
A Novel Mutation (Lys31Arg) in the DMD Gene Impacts on Neuromuscular
Dysfunctions Found by Whole Exome Sequencing and In Silico Analyses in
an Iranian Family
Authors: Omarmeli Vahid , Lewandrowski Kai-Uwe , Assefi Marjan , Faizmahdavi Hanieh , Sharafshah Alireza , Mansouri Nasrin 
Published: January 2024

Background:
Duchene Muscular Disorder (DMD) is a severe X-linked recessive neuromuscular
disease. Previous reports predicted that one-third of cases with a fatal X-linked recessive
disease will be caused by a novel mutation, and the mutation rate for DMD seems to be
higher in males.

Objective:
A novel mutation in the DMD gene DMD (NM_004006.3):c.92A>G (p.Lys31Arg) is
suggested for males because of their heterozygous mothers carrying the mutant alleles

Method:
Whole Exome Sequencing (WES) was done for a 25-year-old female followed by the
screening of the novel mutation in her parents and her brother by the Sanger sequencing technique.
Some in silico analyses were run to find the putative alterations in wild-type and mutant
structures by PolyPhen-2 and Mupro. Notably, SWISS-MODEL was performed to build a reliable
model for the mutant allele based on the PDB ID: 1DXX structure. Also, superimposition
was done by PyMol.

Results:
WES analysis revealed three novel mutations including DLD (exon13:c.G1382A:p.
G461E), ABCA3 (exon12:c.G1404C:p.W468C), and DMD (exon2:c.A92G:p.K31R) in the case.
Focusing on DMD mutation, Sanger sequencing of the patient’s parents and brother indicated no
mutant allele in her mother and brother but a mutant allele in her father as a hemizygous pattern.
In silico analyses showed no considerable change regarding pathogenic impact.

Conclusion:
In conclusion, our findings revealed no pathogenic effect of the new mutation (K31R)
of the DMD gene in an Iranian 25-year-old woman. Because of the DMD importance in preclinical
diagnosis, these data may shed a light on the diagnosis of this mutation in future pregnancies.
Herbal Medicine and Skeletal Muscle Atrophy: From Basic Science to
Translational Medicine
Authors: Seifi Sima , Karimi Afshin , Marjani Abdoljalal , Maftooh Mina , Ghorbani Elnaz , Fiuji Hamid , Ghayour-Mobarhan Majid , Ferns Gordon A. , Khazaei Majid , Hassanian Mehr Seyed Mahdi , Avan Amir 
Published: January 2024

Abstract::
Muscle atrophy is the volume loss and strength of muscle and happens in various
conditions, such as starvation, nerve cutting, cancer cachexia, heart failure, old age, and immobility.
Muscle atrophy is increasing every year and is usually associated with a low quality of
life. In the time of muscle atrophy, systems of proteolytic are turned on and muscle proteins are
degraded, leading to the contraction of muscle fibers. However, the precise mechanisms involved
in muscle atrophy, as well as effective treatments, remain to be investigated. The purpose
of this article is to give an overview of the effectiveness of supplements, herbs, and herb bioactive
compounds on muscle atrophy. The significant beneficial effects of some plants and plantderived
natural products, including curcumin, geranylgeraniol, resveratrol, soy protein, green tea,
and coffee, on muscle atrophy are reviewed in this review article. According to clinical investigations,
these natural products may positively affect the physical function of muscles, including hand
grip strength and knee tension, weight-lifting capacity, muscle fatigue, time and distance traveled
before feeling tired, mitochondrial function and average muscle fiber level. However, more clinical
trials are necessary to explore the possible value of herbal agents on skeletal muscle atrophy.
Analysis of Column Compressive and Adhesive Strengths of Laminated Wood From Pine Pallet Wood Waste and Mahogany as Reinforcement
Authors: Arnandha Yudhi , Indraswari Mufida , Firmansyah Dedy 
Published: January 2024

In Indonesia, the increasing demand for wood as an industrial material and the decline in its production rate, which is usually due to illegal logging, causes the emergence of less efficient wood waste. And one of the methods for efficiently utilizing these waste is through lamination. Accordingly, lamination is a technique that involves the gluing of two or more pieces of wood together. Therefore, the purpose of this study was to determine the value of the adhesive and compressive strength of laminated columns between pine pallet waste and mahogany wood reinforcement. The adhesive strength of 20, 30, 40, and 50 MDGL variations joined together using PVAc glue, as well as the compressive strength with variations of T0 (Pine-Pine-Pine-Pine-Pine), T1 (Mahogany-Pine-Mahogany), T2 (Mahogany-Pine-Mahogany-Pine), and T3 (Mahogany-Pine-Mahogany-Pine-Mahogany) were tested in this study. Furthermore, the adhesive and compressive strength tests were in accordance with the ASTM D905-03 standard and the SNI 03-3958-1995, respectively. The adhesive strength test was carried out at the Building Materials Laboratory, Civil Engineering and Planning Study Program, and Faculty of Engineering at the Yogyakarta State University, while the compressive strength test was performed at the Structural Laboratory, Civil Engineering Department, as well as the Engineering Faculty of Tidar University. Data were then analyzed using the one-way ANOVA test and the results of each variation's adhesive strength test were 1.359 MPa, 564 MPa, 1.699 MPa, and 1.558 MPa for the 20, 30, 40, and 50 MDGL MDGL variations respectively. Furthermore, the results of the compressive strength test with variations T0, T1, T2, and T3 were 6.158 MPa, 7.366 MPa, 7.135 MPa, and 6.923 MPa respectively. It was concluded that the highest adhesive strength was at 40 MDGL and the highest compressive strength was at variation T1 (Mahoni-Pinus-Mahoni).
TO THE MOON AND BACK: THE ADAPTATION OF MOON AS SYMBOL IN MOON KNIGHT'S COMIC TO TELEVISION SERIES ADAPTATION
Authors: Dimas Misbahul Munir  , Dian Leoni Andri  , Fadhilah Desy Handayani  , Gusti Faradila Indrayani  , Hadyan Rosyad  , Mariam Kusniah  , Tatik Apriliya  , Yanti Indah Suryani  
Published: January 2024

Moon Knight is one of the best-selling series in Marvel Studios, and no studies discussed the moon's symbolism in the comic Moon Knight and the TV series adaptations. This paper focuses on a shift in the meaning of the symbol from comics to TV series adaptations. In this research, the qualitative descriptive study is done to reveal whether the TV series adaptation of Moon Knight story faithfully reflects the moon symbolism in the comics. The research uses Hutcheon’s adaptation theory as background to analyze symbol adaptation, from the comic to TV series, and Eliade symbol theory to discuss the shift in the meaning of the symbols. The theory of Dissociative Identity Disorder from Kluft is used to analyze the three characters appear in the one body of the Moon Knight. Using Spradley's analysis method, we conclude that there are differences between the story from the Comic Moon Knight and its TV series adaptation. There were deficiencies that did not fully reflect the moon, and three symbols in the scene were unrelated to each other. The benefit of this research is to find out the significance of the differences in symbols in the adaptation of the Moon Knight series and to become reference material for future researchers who want to discuss the symbolization of the moon in the Moon Knight film.
NARRATIVE TECHNIQUE ANALYSIS OF SHERLOCK HOLMES AND AUGUSTE DUPIN IN A CROSSOVER FANFICTION PARACOSM
Authors: Rista Fathika Anggrela  
Published: January 2024

Narrative technique refers to writers' methods and devices used to tell their stories. Understanding writers' processes and devices to convey their stories is crucial for analyzing and appreciating the arts. However, studying narrative techniques can be complex and requires close attention to detail. This study aims to explain what narrative techniques applied in the crossover fanfiction of Sherlock Holmes and Auguste Dupin to investigate how the narrative form generates impacts on losses and gains of the characterization of Sherlock Holmes and Auguste Dupin in references to their canons and to reveal why the characterization of Sherlock Holmes and Auguste Dupin in the crossover fanfiction are different from their canon. This research uses qualitative methods because the data are in the form of text taken from crossover fanfiction Paracosm (2016) by BiancaAparo. The data are analyzed using Gerald Genette’s narrative techniques. The result of this study showed that the dominant data of narrative techniques applied in Paracosm is narrative mood, which loses their characterization. Narrative mood relates to the position or position of the author, narrator, and characters in a story. That is why the narrative mood is mainly found along with the research objects, the main characters in this fanfiction, Sherlock Holmes and Auguste Dupin. It shows that the two characters have an impact, causing losses of their characteristic. Yet, that does not prevent any gain of the characteristic based on the characters in the original work. Thus, fanfiction can be different from the canon because it is written by different author with different biographical and social elements.
Impact of COVID-19-associated Dysautonomia Phenotypes on the Effectiveness of Venovenous Extracorporeal Membrane Oxygenation
Authors: Savkov G. E. , Petrikov S. S. , Rybalko N. V. , Khamidova L. T. , Markatyuk O. Yu. , Lebedev D. A. , Kiselev K. V. , Vrabiy Yu. N. , Altshuler N. E. , Popugaev K. A. 
Published: January 2024

RELEVANCE. It is known that patients with severe cases of the novel coronavirus infection (COVID-19) are characterized by the development of COVID-19-associated dysautonomia (COVID-19-DA). At the moment, there are no studies examining the impact of this phenomenon on the course and outcomes of the disease in the most severe cohort of patients with COVID-19, namely those requiring venovenous extracorporeal membrane oxygenation (VV ECMO). AIM OF STUDY. The purpose of the presented work is to study the effect of different COVID-19-DA phenotypes on the performance parameters and effectiveness of VV ECMO, gas exchange and hemodynamics in patients with COVID-19. MATERIAL AND METHODS. The study included 20 patients, 12 (60%) women, 8 (40%) men, with COVID-19 who underwent VV ECMO. Patients underwent 24-hour Holter monitoring with assessment of the spectral parameters of heart rate variability (HRV): the low-frequency component (LF), the high-frequency component (HF), the ratio of the low-frequency component to the high frequency component (LF / HF) on days 1, 3, 5 of the VV ECMO. Patients were divided into three groups based on the identified COVID-19-DA phenotypes. The groups were compared in terms of gas exchange, hemodynamics, and VV ECMO performance parameters. RESULTS. The level of partial pressure of carbon dioxide in arterial blood (paCO2) in the phenotype with low sympathetic tone and high tone of the parasympathetic division of the autonomic nervous system (ANS) (lShP) was significantly higher than in the phenotype with normal sympathetic tone and high tone of the parasympathetic division of the ANS (nShP) with equal VV ECMO performance parameters. The heart rate (HR) in the nShP phenotype was significantly lower than in the lShP phenotype. A significant increase in respiratory dysfunction was revealed over time in the lShP phenotype. Weaning from VV ECMO in the nShP phenotype was successful in 50 %, whereas in the lShP phenotype, weaning from VV ECMO was observed in 7,2 % of patients. No significant differences in the mortality rate were obtained. The most common cause of death in both groups was septic shock. CONCLUSIONS. The COVID-19-DA phenotype, manifested by decreased tone of the sympathetic division and increased tone of the parasympathetic division of the ANS, leads to low efficiency of VV ECMO, resulting in a statistically significantly less frequent ECMO discontinuation in those patients.