bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropsychological correlates of obstructive sleep apnea severity in patients with epilepsy
Authors: Latreille Véronique , Willment Kim C. , Sarkis Rani A. , Pavlova Milena 
Published: January 2024

ABSTRACTAims. Obstructive sleep apnea affects up to 30% of patients with epilepsy. As obstructive sleep apnea represents a clinical risk factor for cognitive deficits, its occurrence in epilepsy patients may exacerbate cognitive deficits associated with this condition. However, the cognitive burden of obstructive sleep apnea in epilepsy remains poorly understood. We conducted a retrospective record review of adults with epilepsy who underwent a polysomnography and a neuropsychological assessment at Brigham and Women's Hospital.Methods. We examined the relationship between obstructive sleep apnea severity and cognitive functioning, particularly attention/executive functions, memory, and processing speed in untreated obstructive sleep apnea patients with epilepsy. Twenty patients with epilepsy and mild‐to‐severe obstructive sleep apnea were included in the analyses.Results. We found significant positive correlations between the oxygen saturation levels during rapid‐eye‐movement sleep and attention/executive tests (p<0.05), as well as time spent with saturation levels ≤90% and executive functioning (p=0.008). Similarly, worse verbal memory performances were associated with lower oxygen levels (p=0.003). In addition, more severe respiratory events during rapid‐eye‐movement sleep were associated with worse performances on attention tests (p=0.03).Conclusions. Our findings indicate that more severe obstructive sleep apnea‐related hypoxemia during sleep is associated with poorer cognitive performances on tests that assess attention/executive functions and verbal memory in patients with epilepsy. Overall, these results are consistent with the sleep apnea literature, and suggest that patients with epilepsy are also vulnerable to the effects of obstructive sleep apnea. Future prospective studies will help in determining whether treatment of obstructive sleep apnea may help improve cognitive functioning in patients with epilepsy.
A novel mutation in KCNQ3‐related benign familial neonatal epilepsy: electroclinical features and neurodevelopmental outcome
Authors: Piro Ettore , Nardello Rosaria , Gennaro Elena , Fontana Antonina , Taglialatela Maurizio , Mangano Giuseppe Donato , Corsello Giovanni , Mangano Salvatore 
Published: January 2024

ABSTRACTBenign familial neonatal epilepsy (BFNE) is caused, in about 5% of families, by mutations in the KCNQ3 gene encoding voltage‐gated potassium channel subunits. Usually, newborns with BFNE show a normal neurological outcome, but recently, refractory seizures and/or developmental disability have been reported suggesting phenotype variability associated with KCNQ3‐related BFNE. Here, we describe a proband from a BFNE family carrying a novel variant in the KCNQ3 gene. Regarding the paucity of data in the literature, we describe the presented case with a view to further establishing: (1) a genotype/phenotype correlation in order to define a BFNE phenotype associated with favourable outcome; (2) an electroclinical pattern associated with BFNE based on video‐EEG recording; (3) appropriate first‐line AEDs; and (4) the duration of AED treatment. The presented case from Day 3 exhibited a cluster of ictal events, identified as epileptic seizures on Day 10 based on continuous video‐EEG polygraphy. The seizures were characterized by asymmetric tonic posturing, associated with a generalized decrease in EEG amplitude, and followed by bilateral asynchronous clonic movements associated with bicentral sharp‐wave discharges. The seizures were refractory to intravenous pyridoxine, whereas levetiracetam resulted in rapid total seizure control which has remained to date. This study demonstrates that the novel heterozygous KCNQ3 (c. 914A>T; p.Asp305Val) variant, affecting residues in the pore region, is associated with a specific electroclinical pattern and favourable neurodevelopmental outcome. [Published with video sequence on www.epilepticdisorders.com]
Epilepsy surgery in the first months of life: a large type IIb focal cortical dysplasia causing neonatal drug‐resistant epilepsy
Authors: Borggraefe Ingo , Tacke Moritz , Gerstl Lucia , Leiz Steffen , Coras Roland , Blümcke Ingmar , Giese Armin , Ertl‐Wagner Birgit , Thiel Christian T. , Noachtar Soheyl , Peraud Aurelia 
Published: January 2024

ABSTRACTFocal cortical dysplasia is a common cause of medically refractory epilepsy in infancy and childhood. We report a neonate with seizures occurring within the first day of life. Continuous video‐EEG monitoring led to detection of left motor seizures and a right frontal EEG seizure pattern. Brain MRI revealed a lesion within the right frontal lobe without contrast enhancement. The patient was referred for epilepsy surgery due to drug resistance to vitamin B6 and four antiepileptic drugs. Lesionectomy was performed at the age of two and a half months, and histopathological evaluation confirmed the diagnosis of focal cortical dysplasia type IIb (FCD IIb). The patient is free of unprovoked seizures without medication (Engel Class I) and is normally developed at 36 months after surgery. The case study demonstrates that FCD IIb may cause seizures within the first day of life and that epilepsy surgery can be successfully performed in medically intractable patients with a clearly identifiable seizure onset zone within the first three months of life. Although radical surgery such as hemispherectomy and multi‐lobar resections are over‐represented in early infancy, this case also illustrates a favourable outcome with a more limited resection in this age group.
Childhood epilepsy with a small number of seizures may be left untreated: an international prospective study
Authors: Arts Willem F. , Geerts Ada T. , Brouwer Oebele F. , van Donselaar Cees A. , Stroink Hans , Peters Boudewijn AC. , Peeters Els AJ. , Camfield Peter , Camfield Carol 
Published: January 2024

ABSTRACTAims. It is unknown whether treatment with antiepileptic drugs in children with epilepsy with a presumed good prognosis is always necessary. We aimed to study the course of newly diagnosed epilepsy in children with a presumed good prognosis who are managed without AED treatment.Methods. A total of 151 children (one month to 12 years of age) with two to five lifetime unprovoked seizures (excluding febrile convulsions), were followed for three years. Treatment was initially withheld. Children with symptomatic epilepsy, or absence or myoclonic epilepsy, were excluded. AED treatment was started after >10 lifetime seizures or an episode of status epilepticus during follow‐up, or if the parents or treating physician deemed it otherwise necessary.Results. During follow‐up, 113 children continued to meet our criteria for refraining from treatment with antiepileptic drugs, yet 30 started treatment at the request of the parents. Thirty‐eight children at some time met the criteria to start treatment, but the parents of 16 declined treatment. In all, 99 (66%) children maintained the no‐treatment regime. Ninety‐eight children (65% of 151) reached terminal remission for at least one year, including 83 who did not receive antiepileptic drug treatment (84% of the untreated 99). Mean terminal remission was significantly longer in the group with a total of <10 seizures compared to those with >10 seizures. Treatment did not increase the length of terminal remission. Adverse events, including traumatic injury, occurred equally in the treated and untreated children. Measures of quality of life suggested a better outcome in those without treatment.Conclusions. Children with newly diagnosed epilepsy with a presumed good prognosis may not need immediate AED treatment. Postponing treatment does not alter the chance of remission or the risk of accidents and adverse events and appears to be associated with a good quality of life.
Loss of responsiveness in psychogenic non‐epileptic seizures
Authors: Asadi‐Pooya Ali A. , Bahrami Zahra 
Published: January 2024

ABSTRACTAims: The aim of this study was to investigate the frequency of loss of responsiveness (LOR) in patients with psychogenic non‐epileptic seizures (PNES) and to characterize the patients' clinical variables that may be associated with such a manifestation.Methods: In this retrospective study, all patients with documented PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were investigated.Results: During the study period, data was available for 324/325 patients with PNES. In total, 275 patients (85%) reported LOR during their seizures, but this was not the case for 49 patients (15%). The model, generated by regression analysis, was shown to be significant (p=0.0001) and LOR could be predicted in 84% of the patients. Closed eyes during seizures (OR: 4.4; 95% CI: 2.101–9.235; p=0.0001) and seizure‐associated injury (OR: 3.5; 95% CI: 1.402–8.686; p=0.007) were significantly associated with LOR based on the model.Conclusion: Patients with PNES may frequently report LOR, which is significantly associated with seizure‐related injuries. Therefore, it is important to apply appropriate management strategies for patients with PNES and LOR in order to prevent or decrease the possibility of any associated consequences, including ictal injury.
Multinodular and vacuolating neuronal tumour of the cerebrum: a rare neuroimaging incidentaloma or a potentially treatable cause of focal epilepsy?
Authors: Baščarević Vladimir , Pejović Aleksa T. , Ristić Aleksandar J. , Vojvodić Nikola , Raičević Savo , Đukić Tijana , Brajković Leposava , Sokić Dragoslav 
Published: January 2024

ABSTRACTMultinodular and vacuolating neuronal tumour (MVNT) of the cerebrum is a relatively new, well defined histopathological and neuroradiological entity, in many cases associated with an early adult‐onset epilepsy. These lesions have an indolent course and resemble both malformative and neoplastic processes, combining a focal developmental anomaly and a low‐grade tumour. Herein, we report a case of a 48‐year‐old female patient with left temporal lobe epilepsy associated with MVNT. In addition, a comprehensive review of all the previously published cases is provided with a focus on seizure‐related cases, surgical treatment, and postoperative outcome.
Quantitative EEG analysis in Encephalopathy related to Status Epilepticus during slow Sleep
Authors: Cantalupo Gaetano , Pavlidis Elena , Beniczky Sandor , Avanzini Pietro , Gardella Elena , Larsson Pål G. 
Published: January 2024

AbstractSince its first description, quantifying the burden of epileptiform abnormalities in sleep EEG has played a fundamental role in the diagnosis of Encephalopathy related to Status Epilepticus during slow Sleep (ESES). In fact, in the 1971 seminal paper by Tassinari's group and in the following studies on this syndrome, the amount of epileptiform discharges (EDs) was calculated as the percentage of slow sleep occupied by spike‐and‐waves and referred to as “spike and wave index” (SWI). However, nowadays it is becoming increasingly clear that the SWI alone does not explain the whole clinical course of patients affected by ESES. In this paper, we aim to provide a state‐of‐the‐art summary of the quantitative EEG methods currently used in the ESES/CSWS literature, highlighting the possible pitfalls and discrepancies explaining the unsatisfactory correlation between SWI and clinical course. Furthermore; we illustrate a number of methodological refinements ‐ taking into account inter‐individual, intra‐individual, and temporal variability of EDs ‐ alongside “new” quantitative variables ‐including ED‐related and sleep‐related features ‐ potentially useful to reach a reliable electro‐clinical correlation in patients with ESES.
Clinical evolution and epilepsy outcome in three patients with CDKL5‐related developmental encephalopathy
Authors: Bernardo Pia , Ferretti Alessandro , Terrone Gaetano , Santoro Claudia , Bravaccio Carmela , Striano Salvatore , Coppola Antonietta , Striano Pasquale 
Published: January 2024

ABSTRACTAims. To further characterise CDKL5‐related disorder, previously classified as an early‐onset seizure variant of Rett syndrome, which is currently considered a specific and independent early‐infantile epileptic encephalopathy.Methods. We describe the epileptic phenotype and neurocognitive development in three girls with CDKL5 mutations showing severe neurodevelopmental impairment, with different epileptic phenotypes and severity.Results. The patients differed regarding age at epilepsy onset, seizure frequency, duration of “honeymoon periods”, as well as EEG features. The “honeymoon period”, defined as a seizure‐free period longer than two months, represented, in our case series, a good indicator of the epilepsy outcome, but not of the severity of developmental impairment. However, even during the “honeymoon period”, the interictal EEG showed epileptiform abnormalities, slowing, or a disappearance of physiological pattern. The natural history of CDKL5 disorder was compared between the three girls, focusing on the relationship between electroclinical features and neurological development.Conclusion. Our findings suggest that CDKL5 mutations likely play a direct role in psychomotor development, whereas epilepsy is one of the clinical features associated with this complex disorder.
Temporal encephalocele: a novel indication for magnetic resonance‐guided laser interstitial thermal therapy for medically intractable epilepsy
Authors: Ranjan Manish , Wilfong Angus W. , Borewinkle Varina , Jarrar Randa , Adelson P. David 
Published: January 2024

ABSTRACTTemporal encephalocele (TE) is a rare but surgically treatable/curable cause of temporal lobe epilepsy (TLE). The surgical intervention varies from local disconnection to extensive anterior temporal lobectomy and amygdalohippocampectomy (ATL/AH). Magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) has evolved as a minimally invasive alternative for intractable epilepsy with good results, however, application of MRgLITT for intractable pediatric epilepsy secondary to TE has not been reported. We present a detailed technical report and clinical experience of MRgLITT in two adolescent children with medically intractable TLE secondary to TE. Pre‐surgical evaluation revealed anterior inferior TE with concordant clinico‐electrophysiological data. Both the patients underwent MRgLITT after review with the institutional multidisciplinary epilepsy team and discussion with the patient and the family. Both the patients were discharged on post‐operative day one and have been seizure‐free since the procedure at the last follow‐up visit at 18 months and 6 months, respectively. The present series demonstrates first‐ever clinical and technical experience of MRgLITT for TE with intractable pediatric epilepsy. The excellent post‐operative seizure outcome and favorable postoperative course support MRgLITT as the first line of surgical intervention for TE with intractable TLE and broadens the application of MRgLITT.
Comparison of clinical and electrophysiological characteristics between ictal and cardiac asystole encountered during video‐EEG monitoring
Authors: Sankaranarayanan Muthukani , Makhija Prashant , Gopinath Siby , Mathew Navin , Radhakrishnan Kurupath 
Published: January 2024

ABSTRACT

Aims
. Differentiation between syncope secondary to epileptic seizures and cardiac disease in patients displaying transient loss of consciousness associated with convulsive movements is a diagnostic challenge both for neurologists and cardiologists. In such patients, prolonged video‐EEG monitoring not only helps in identifying asystole as the cause of syncope, but also in categorizing asystole as primarily cardiac in origin (cardiac asystole) and secondary to epileptic seizures (ictal asystole). We carried out this study to ascertain the prevalence of asystole in an epilepsy monitoring unit, and to contrast the clinical and electrophysiological characteristics between ictal asystole and cardiac asystole.

Methods
. Through a retrospective search, we identified patients who were shown to have had asystole using a database of patients who underwent prolonged video‐EEG monitoring during a 68‐month period. We compared the data of 18 consecutive patients; five with ictal asystole and 13 with cardiac asystole, with 121 and 64 events recorded from them, respectively.

Results
. Of the 10,096 patients who underwent prolonged video‐EEG monitoring during the study period, we identified 18 (0.17%) patients with asystole. Cardiac asystole was 2.6 times more frequent than ictal asystole. Older age at onset, heralding symptoms of presyncope, occurrence during wakefulness, and brief duration of the events supported the diagnosis of cardiac asystole. Ictal asystole events were more protracted, and prolonged asystole more frequently occurred in patients with extratemporal seizures compared to temporal lobe seizures. Asystole occurred in only half of the recorded seizures.

Conclusions
. The accurate categorization of asystole as seizure‐related or heart disease‐related has huge implications for management strategy and outcome. The necessity of permanent pacemaker implantation is more frequent and urgent in patients with cardiac asystole because of the greater risk of sudden death. Hence, in patients with an ominous diagnosis of cardiac asystole, a thorough cardiac evaluation should surpass neurological evaluation.
Multimodal assessment of language and memory reorganization: a proof of concept in two patients with drug‐resistant temporal lobe epilepsy
Authors: Roger Elise , Pichat Cédric , Renard Félix , Cousin Emilie , Perrone‐Bertolotti Marcela , Hot Pascal , Minotti Lorella , Job Anne‐Sophie , Kahane Philippe , Trebuchon Agnes , Krainik Alexandre , Baciu Monica 
Published: January 2024

ABSTRACTAims. We report two patients suffering from drug‐resistant temporal lobe epilepsy to show how their neuroplasticity can be apprehended using a multimodal, integrative and clinically relevant approach.Methods. This is a proof of concept based on using multimodal data including: (1) white matter structural connectivity (DTI) of the main tracts involved in language and memory; (2) neurophysiological biomarkers (fMRI‐BOLD signal and LI lateralization indices); and (3) cognitive scores as measured during the neuropsychological assessment. We characterized tri‐modal data for each patient using a descriptive integrative approach, in terms of reorganization and by comparing with a group of healthy participants.Conclusions. This proof of concept suggests that the inclusion of multimodal data in clinical studies is currently a major challenge. Since the various datasets obtained from MRI neuroimaging and cognitive scores are probably interrelated, it is important to go beyond the mono‐modal approach and move towards greater integration of several multimodal data. Multimodal integration of anatomical, functional, and cognitive data facilitates the identification of comprehensive neurocognitive patterns in epileptic patients, thus enabling clinicians to differentiate between reorganization profiles and help to predict post‐surgical outcomes for curative neurosurgery.
Stimulus‐induced rhythmic, periodic ictal discharges during funduscopic examination in a patient with status epilepticus
Authors: Hong Wei‐Pin , Chen Tsang‐Shan , Huang Chin‐Wei 
Published: January 2024

ABSTRACTStimulus‐induced rhythmic, periodic, or ictal discharges (SIRPIDs), an unusual pattern in electroencephalography, have been described in critically‐ill encephalopathic patients in response to alerting stimuli. The phenomenon may be seen in patients with a broad range of aetiologies, including cerebral infarct, haemorrhage, anoxia, and degenerative diseases. Here, we report a unique case of status epilepticus presenting with SIRPIDs during funduscopic examination‐induced focal to bilateral tonic‐clonic seizures.
The localizing value of epileptic auras: pitfalls in semiology and involved networks
Authors: Russo Angelo , Arbune Anca Adriana , Bansal Lalit , Mindruta Ioanna , Gobbi Giuseppe , Duchowny Michael 
Published: January 2024

ABSTRACTA more complete understanding of the epileptic aura represents an important challenge for localizing the epileptogenic zone and understanding brain networks. This review re‐visits the localizing value of the epileptic aura, focusing on clinical pitfalls in epileptogenic zone detection and the importance of defining functional connectivity. We review the role of network node activation or alteration and its relationship to hub activation.
Prolonged EEGs in adult patients with a first unprovoked seizure: a prospective pilot study
Authors: Shapiro Michelle , Foster Gary 
Published: January 2024

ABSTRACT

Aims
. Definitions of epilepsy have changed to include a first unprovoked seizure with a high (>60%) risk of recurrence in the next 10 years. A single seizure and an epileptiform discharge on an EEG would suffice for this diagnosis. We hypothesized that an extended six‐hour EEG in adult patients presenting with a first unprovoked seizure would demonstrate an increased yield of epileptiform discharges in comparison to a standard 30‐minute EEG, and therefore higher rates of epilepsy diagnosis.

Methods
. Thirty‐eight patients were recruited at Hamilton Health Sciences over six years and 36 underwent extended six‐hour EEGs.

Results
. Two of seven patients demonstrated epileptiform discharges on their EEG after only the first 30 minutes of recording, observed during sleep for both patients. This correlated to an overall increase of 5.56%, or a yield of 29%.

Conclusion
. A third more patients could benefit from early diagnosis with extended EEGs. The rate of epilepsy diagnosis based on EEG overall was superior to that of brain imaging (19%
versus
6%). Given the limitations due to sample size in this study, a larger trial would be beneficial to confirm these findings.
Space-based Applications of Remote Sensing in Studying Open-pit Mining and Ecology at Non-metallic Mineral Deposits in Russia
Authors: Zenkov I.V. , Le Hung Chin , Dmitrieva M.L. , Yuronen Yu.P. , Cherepanov E.V. , Mironova Zh.V. , Gerasimova E.I. , Skornyakova S.N. , Kondrashov P.M. , Kustikova E.A. 
Published: January 2024

Based on the remote sensing data, comprehensive information is provided on mining landscapes at deposits of mineral raw materials for production of cement, crushed stone, metallurgical fluxes, and asbestos products, which are in open-pit mining in the mining regions of Russia. Using high-resolution satellite images, the amount of mining transport equipment in quarries at non-metallic mineral deposits has been determined. The volume of diesel fuel consumed by dump trucks when removing rocks from quarries has been calculated. The volume of toxic substances released into atmosphere during the operation of quarry vehicles in the being developed deposits of non-metallic minerals has been established.
Un viajero nacionalista por los Andes: Comentario a propósito de una nueva edición de ‘Paisajes peruanos’, de José de la Riva-Agüero y Osma
Authors: Gómez Acuña Luis 
Published: January 2024

Paisajes peruanos es una de las mejores obras de corte histórico-literario realizadas por el historiador José de la Riva-Agüero y Osma. Ella ha sido siempre caliﬁcada como un relato de viaje, el cual fue, por cierto, bastante singular. Así, un joven limeño, doctor en Letras por la Universidad de San Marcos, descendiente de la antigua nobleza virreinal peruana, realizó en 1912 un viaje por los Andes siguiendo grosso modo el camino virreinal entre Cusco y Huancayo. Sus apuntes de viaje se constituyeron con el correr del tiempo en un erudito relato de viaje polifónico, de clara prosa modernista. Ello, por cierto, no agota la riqueza de dicho texto: Paisajes peruanos es, también, una clara visión de lo que el joven liberal Riva-Agüero pensaba que era y debía ser la nación peruana.