bluuebunny/crossref_metadata_2025_split huggingface dataset:
The level of metabolic hormones in young people with arterial hypertension against the background of abdominal obesity
Authors: Polonskaya Ya. V. , Kashtanova E. V. , Stakhneva E. M. , Shramko V. S. , Sadovski E. V. , Ledovskikh S. R. , Shcherbakova L. V. , Garbuzova E. V. , Khudyakova A. D. , Ragino Yu. I. 
Published: October 2023

Aim. To study the level of metabolic hormones in young people with arterial hypertension (AH) against the background of abdominal obesity (AO).Materials and methods. The study included 498 people who were divided into two groups. The experimental group encompassed 250 people with AH, of which – 159 people had AO, the average systolic pressure – 141.9 ± 13.9 mm Hg, diastolic pressure – 95.6 ± 7.5 mm Hg. The control group included 248 people comparable to the experimental group by gender and age, of whom 104 people had AO, the average systolic pressure – 118.5 ± 9.8 mm Hg, diastolic pressure – 77.8 ± 7.4 mm Hg. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon, insulin, pancreatic polypeptide (PP), and peptide YY (PYY) were determined by the multiplex analysis. The level of glucose was determined by the enzymatic method. Statistical processing of the results was carried out using the SPSS 13.0 software.Results. Patients with AH had higher levels of amylin, C-peptide, and glucose and lower levels of PYY. There was no significant difference between the experimental group and the control group for the rest of the studied parameters. In the experimental group, the C-peptide, GLP-1, glucagon, and insulin levels were associated with AO. In the control group, the association of AO with the levels of C-peptide, insulin, and glucose was shown. The odds of AH in people under the age of 45 years were associated with a decrease in the level of PYY, a rise in the amylin levels, and an increase in waist circumference.Conclusion. Of the studied metabolic hormones, an increased level of amylin and reduced PYY can serve as potential biomarkers indicating high odds of developing AH in people under 45 years of age. AO is a factor that contributes to the development of AH at a young age.
All you need to know about sarcopenia: a short guide for an internal medicine physician in questions and answers
Authors: Bikbavova G. R. , Livzan M. A. , Tikhonravova D. V. 
Published: October 2023

Sarcopenia is associated with social, economic, and individual burdens, including loss of independence, poor quality of life, and disability. In a short period of time, ideas about sarcopenia transformed from geriatric syndrome to disease. Initially, sarcopenia was considered in the context of gradual age-related deterioration in the functioning of all physiological systems. Over the years, it became clear that it can develop a second time, as a consequence of various diseases and pathological conditions.To date, there have been no generally accepted diagnostic criteria for sarcopenia. There are several tests and tools available for screening sarcopenia, the choice of which depends on physical capabilities of the patient, capabilities of the medical institution, and the purpose for which it is detected (research or clinical practice).From the point of view of human health, sarcopenia increases the risk of falls and fractures; impairs the ability to perform daily activities; is associated with the progression of major diseases and cognitive impairments; leads to movement disorders; contributes to a decrease in the quality of life, loss of independence or a need for long-term care. The presence of sarcopenia increases both the risk of hospitalization and hospitalization costs.The aim of the literature review is to provide an analysis of up-to-date information on the causes, pathogenesis, screening, diagnosis, treatment, and consequences of sarcopenia, myosteatosis, and sarcopenic obesity. The search for literature containing information on relevant studies was conducted in PubMed and Google Scholar by the following keywords: sarcopenia, dynapenia, myosteatosis, sarcopenic obesity, nutritional status, malnutrition.
Effect of potassium humate spray on some biochemical characteristics in potato leaves Solanum tuberosum under water stress conditions
Authors: Hassan Hadia , Suleiman Sawsan , Dais Maher 
Published: October 2023

نفذت الدراسة في محطة بحوث الهنادي التابعة لمركز البحوث العلمية الزراعية في اللاذقية خلال العروة الربيعية لموسم 2020 وذلك لدراسة تأثير الرش الورقي بتراكيز متباينة من هيومات البوتاسيوم 1500,1000,500 ppm على نباتات البطاطا صنف سبونتا عند مستويي ري 40و80 % من السعة الحقلية . استخدم في تصميم التجربة نظام العشوائية الكاملة ضمن القطع المنشقة. شملت التجربة 4 معاملات و3 مكررات لكل معاملة عند كل مستوى رطوبة. تم رش النباتات بالهيوماتHA بعد 35 يوم من الزراعة لثلاثة مرات، بفاصل عشرة أيام بين الرشة والأخرى.
أظهرت النتائج زيادة محتوى السكريات الذائبة الكلية ومحتوى البرولين وفعالية الكاتالاز في أوراق البطاطا المجهدة في حين انخفض محتواها من الكلوروفيل .كما حسنت المعاملة بهيومات البوتاسيوم الصفات المدروسة عند المستوى 40 % ، وأعطت معاملة الهيومات بتركيز1000 ppm أعلى محتوى من الكلوروفيل الكلي 0.142مليمول / مغ ، والسكريات الذائبة الكلية1.67ملغ/غ . بينما أعطت معاملة الهيومات بتركيز 1500 ppm أعلى محتوى للبرولين 45.65 ppm و زادت فعالية الكاتالاز 0.04 مغ/غ عند المستوى 40 %. و عند المستوى 80 % تميزت معاملة الهيومات 1000ppm بأعلى محتوى للكلوروفيل الكلي في أوراق البطاطا 0.140 مليمول /مغ وأعلى محتوى من البرولين 11.63 ppm. وبالتالي يمكن تطبيق هيومات البوتاسيوم بالتركيز1000 و ppm 1500 لرفع كفاءة تحمل نبات البطاطا صنف سبونتا تحت ظروف نقص الماء.
Synthesis of Molecularly Imprinted Polymers for Selective Extraction Followed by Solid Phase Determination of Metformin in Pharmaceutical Preparation and in Human Serum
Authors: Aldeen Rana A. Kamal , Al-Bayati Yehya K. 
Published: October 2023

يوضح هذا البحث تحضير وتخزين البوليمرات الجزيئية المطبوعة (MIP) في درجة حرارة الغرفة عن طريق البلمرة الصلدة لـ (Metformin (Met والتي تتميز بالحساسية العالية والتكلفة المنخفضة والاستقرار العالي. اذ تم أخذ نسب 0.8: 4: 20 ملي مول للقالب ، و للمونومر ولعوامل الربط المتصالب للبلمرة من أجل ضمان قدرة امتزاز مناسبة. المونومر الوظيفي الستايرين C8H8 تم ربطه مع إيثيلين جليكول ثنائي ميثاكريلات EGDMA C10H14O4 رابط التشابك وبالتالي إنشاء MIP لـ Metformin كـ Met-MIP تم تمييزه باستخدام مقياس الطيف الضوئي UV-VIS عند 236 نانومتر في الادوية الصيدلانية ومصل الانسان ، والتحليل الطيفي بالأشعة تحت الحمراء والمسح المجهري الإلكتروني للطبعة الدوائية. أنشأت عملية الشطف التي تم تطبيقها على القالب اي انتزاع القالب ال Met من Met-MIP تجاويف ناتجة عن استخدام المذيب المكون للفجوات المكون من الميثانول والكلوروفورم وحمض الخليك (10:20:70) مللترعلى التوالي. كانت السعة القصوى للامتزاز Met-MIP هي 1.2320 ، 2.4448 ميكرو مول / غم عند استخدام وزن 0.1 و0.2 غم من Met-MIP على التوالي. استخدمت سرنجة الطور الصلب (SPE) المعبأة ببوليمرات مطبوعة جزيئيًا (MIPs) للفصل الانتقائي والتركيز للميتفورمين في العديد من الأدوية الصيدلانية من عدة مصادر. اعتمد المصل البشري على استخدام الماء منزوع الأيونات لتخفيف المصل ، يليه تسخين المصل مع الميثانول ، ثم اضافة بضع قطرات من حمض الهيدروكلوريك 1M للحصول على محلول رائق ليتم الكشف عن الميتفورمين في منطقة الأشعة فوق البنفسجية عند طول موجي 236 نانومتر من خلال تطبيق طريقة الإضافة القياسية.
Biosynthesis of Silver Nanoparticles by Using Green Tea (Camellia sinensis) Extracts
Authors: Salih Hawazen H. 
Published: October 2023

اصبح تركيب جسيمات الفضة النانوية بالطرق الخضراء بواسطة النباتات شائعًا بشكل متزايد بسبب ملاءمته للبيئة ، وتوفره ، وفعاليته وكلفته القليلة ، ويمكن التعامل معه بأمان ويمتلك تنوعًا واسعًا من المركبات الفعالة ، مثل مضادات الأكسدة و ومركبات مضادة للميكروبات. في الدراسة الحالية ، تم تصنيع جسيمات الفضة النانوية AgNPs باستخدام المستخلصات المائية والميثانولية لأوراق الشاي الاخضر التي اختزلت نترات الفضة, والتي تم توصيفها باستخدام العديد من التقنيات التحليلية مثل القياس الطيفي المرئي فوق البنفسجي (UV-Vis) ، والتحويل الطيفي بالأشعة تحت الحمراء (FTIR) ، والفحص المجهري الذري (AFM) ، وتشتت الأشعة السينية (XRD) وفحص جهد زيتا. أشارت الملاحظة البصرية إلى أن لون نترات الفضة المائية قد تحول بعد المعاملة بمستخلصات الأوراق وتأكد ذلك بواسطة أطياف UV-Vis. فضلا عن ذلك ، أظهر تحليل AFM أن الجسيمات كانت كروية الشكل ، مفردة أو في مجاميع بمتوسط ​​أحجام 108.3 و 84.76 نانومتر للمستخلصات المائية والميثانولية على التوالي. كذلك, أكدت تقنية XRD الطبيعة البلورية للجسيمات النانوية, وتم تقدير متوسط ​​الحجم وفقًا لمعادلة شيرير اذ بلغت 61.24 و 99.66 نانومتر للمستخلصات المائية والميثانولية (CANPs) على التوالي. بالإضافة إلى قيم زيتا المحتملة كانت-30.31 و -32.33 مللي فولت للمستخلصات المائية والميثانولية CANPs على التوالي.
“Zero change” platform for monolithic back-end-of-line integration of phase change materials in silicon photonics
Authors: Lin Hongtao , Wei Maoliang , Xu Kai , Tang Bo , Li Junying , Yun Yiting , Zhang Peng , Wu Yingchun , Bao Kangjian , Lei Kunhao , Chen Zequn , Ma Hui , Sun Chunlei , Liu Ruonan , Li Ming , Li Lan 
Published: October 2023

Abstract
Monolithic integration of novel materials for unprecedented device functions without modifying the existing photonic component library is the key to advancing heterogeneous silicon photonic integrated circuits. To achieve this, the introduction of a silicon nitride etching stop layer at selective area, coupled with low-loss oxide trench to waveguide surface, enables the incorporation of various functional materials without disrupting the reliability of foundry-verified devices. As an illustration, two distinct chalcogenide phase change materials (PCM) with remarkable nonvolatile modulation capabilities, namely Sb2Se3 and Ge2Sb2Se4Te1, were monolithic back-end-of-line integrated into silicon photonics. The PCM enables compact phase and intensity tuning units with zero-static power consumption. Taking advantage of these building blocks, the phase error of a push-pull Mach-Zehnder interferometer optical switch could be trimmed by a nonvolatile phase shifter with a 48% peak power consumption reduction. Mirco-ring filters with a rejection ratio >25dB could be applied for >5-bit wavelength selective intensity modulation, and waveguide-based >7-bit intensity-modulation photonic attenuators could achieve >39dB broadband attenuation. The advanced “Zero change” back-end-of-line integration platform could not only facilitate the integration of PCMs for integrated reconfigurable photonics but also open up the possibilities for integrating other excellent optoelectronic materials in the future silicon photonic process design kits.
Highly defective ultra-small tetravalent MOF nanocrystals
Authors: Tissot Antoine , Dai Shan , Serre Christian , Simms Charlotte , Parac-Vogt Tatjana , Patriarche Gilles , Daturi Marco 
Published: October 2023

Abstract

The size and defects in crystalline inorganic materials are of importance in many applications, particularly catalysis, as it often results in enhanced/emerging properties. So far, applying the modulation chemistry strategy has been unable to afford high-quality functional Metal–Organic Frameworks (MOFs) nanocrystals with minimized size while exhibiting maximized defects. We report here a general sustainable strategy for the design of highly defective and ultra-small tetravalent MOFs (Zr, Hf) crystals (ca. 35% missing linker, 4–6 nm). Advanced characterizations have been performed to shed light on the main factors governing the crystallization mechanism and to identify the defects’ nature. The ultra-small nanoMOFs showed exceptional performance in peptide hydrolysis reaction, including high reactivity, selectivity, diffusion, stability, and show emerging tailorable reactivity and selectivity towards peptide bond formation by changing the reaction solvent. Therefore, these highly defective ultra-small M(IV)-MOFs particles open new perspectives for the development of heterogeneous MOF catalysts with dual functions.
Effects of polyunsaturated fatty acids supplementation on the biochemical parameters, milk fatty acid composition, and production performance of Holstein dairy cows around parturition
Authors: Amini Mahmood Reza , naserian abasali , Babazadeh Daryush , Razavi Seyed Amin , Valizadeh Reza , Dirandeh Essa , Baghshahi Hojjat 
Published: October 2023

Abstract
The present study evaluated the effects of switching from fatty acids, n-6 polyunsaturated (PUFA) to n-3 (PUFA) supplements while maintaining constant lipogenic and glucogenic diets around calving period. A total of 30 Holstein cows, selected based on their body condition and parity, were divided into three treatment groups. The cows were blocked from 21 (± 2) days before calving to 42 days post-calving.The teatments included a group that received a basal diet (control group), a group that received basal diet with 1.38% dry matter (DM) of palm fat, a saturated fatty acid (SFA group), and a group received 5% (DM) of safflower seeds (source of n-6 PUFA) from day 21 before calving to the day 21 after calving and 3.85% (DM) of flaxseed (n-3, PUFA) from the day 21 to day 42 after calving (Omega group). The feed supplemented with saturated and PUFA could increase milk production in comparison to the control group. Beta-hydroxybutyrate (BHBA) concentration was significantly greater in the SFA and the Omega groups compared to the control group. Insulin levels before and after calving were greater in the Omega group than in the SFA group. Among the inflammatory and immune factors, the malondialdehyde (MDA) levels were significantly greater in the Omega group during the prepartum period and total antioxidant capacity in the SFA and Omega groups during the entire experiment. Consequently, supplementing n-6 PUFA during the close-up and n-3 PUFA during the early lactation period can increase milk production without affecting dry matter intake.
The effects of obesity on surgical complications and postoperative prognosis of epithelial ovarian cancer: a meta-analysis
Authors: Sheng Jingjing , Zhou Yunxiao , Yuan Zhilin , Jin Zujian , Li Chu , Huang Yiping 
Published: October 2023

Abstract

ObjectiveTo comprehensivelyevaluate and compare surgical outcomes of obese patients versus non-obese patients for surgical complications and postoperative prognosis due to epithelial ovarian cancer.MethodsStudies were obtained from database search systems of, Medline (PubMed) and Embase. Data were analyzed by the meta-analysis method and the random-effect or fixed-effect model. The heterogeneity between the studies was evaluated byI2 index and the data were analyzed using STATA version 15.1 and Review Manager version 5.4.Results14 studies with 4858 cases of proven epithelial ovarian cancer who underwent extensive surgery were included. Obesity may be a risk factor of the low surgical complex score (RR 1.08, 95% CI 1.01–1.15, p = 0.05), but had no manifesting difference in the surgical complications scorecompared non-obesity group (RR 0.50, 95% CI 0.07–3.79, p = 0.501 and RR 0.60, 95% CI 0.22–1.63,p = 0.316). Obesity EOC patients who undergone surgery tended to be correlated with surgical complications, such as wound infection (RR 2.71, 95% CI 1.59-4.61, p = 0.000), intestinal complications (RR 2.09, 95% CI 1.00-4.35, p = 0.000), and 30-readmission rate (RR 1.84, 95% CI 1.16-2.93, p = 0.000). Obese patients were more likely to have shorter prognosis free survival (PFS) (SMD0.62-year, 95% CI − 0.13 to 0.15), but the results did not discover a significant difference in overall survival (OS)between obesity and non-obesity. (SMD 0.01-year, 95% CI − 0.13 to 0.15)ConclusionsObesity affects the difficulty of ovarian cancer surgery, and a negative relationship between obesity and surgical complications is observed. Obesity is a potential risk factor for prognosis of EOC patients. Attention is played on determining what kind of case should be benefit most from this surgery to minimize the rates of operativecomplications and postoperative mortality.PROSPERO registration number: CRD 42023434781
Self-reactive germline-like TCR alpha chains shared between blood and pancreas
Authors: Linsley Peter , Nakayama Maki , Balmas Elisa , Chen Janice , Pour Fariba , Bansal Shubham , Serti Elisavet , Speake Cate , Pugliese Alberto , Cerosaletti Karen 
Published: October 2023

Abstract

Human islet antigen reactive CD4 + memory T cells (IAR T cells) from peripheral blood have been studied extensively for their role in the pathogenesis of autoimmune type 1 diabetes (T1D). However, IAR T cells are rare, and it remains poorly understood how they affect T1D progression in the pancreas. Using single cell RNA-sequencing coupled with a multiplexed activation induced marker (AIM) enrichment assay, we identified paired TCR alpha/beta (TRA/TRB) T cell receptors (TCRs) in IAR T cells from the blood of healthy, at-risk, new onset, and established T1D donors. Using TCR sequences as barcodes, we measured infiltration of IAR T cells from blood into pancreas of organ donors with and without T1D. We detected extensive TCR sharing between IAR T cells from peripheral blood and pancreatic infiltrating T cells (PIT), with perfectly matched or single mismatched TRA junctions and J gene regions, comprising ~ 34% of unique IAR TCRs. PIT-matching IAR T cells had public TRA chains that showed increased use of germline-encoded residues in epitope engagement and a propensity for cross-reactivity. The link with T cells in the pancreas implicates autoreactive IAR T cells with shared TRA junctions and increased levels in blood with the prediabetic and new onset phases of T1D progression.
Comparative Analysis of Ocular Biometrics using Spectral Domain Optical Coherence Tomography with Purkinje Image and Optic Nerve Head Alignments in Mice
Authors: Sze Ying Hon , Zuo Bing , Lu Da Qian , Li King Kit , Tse Dennis Yan Yin , Zhao Qian , Lam Thomas Chuen 
Published: October 2023

Abstract

Background
Myopia is the leading cause of distance refractive error, in which objects form in front of the retina rather than on the retina itself during emmetropization. Mice is an emerging model for experimental myopia. This study aims to compare ocular biometric measurements with Purkinje image-based and optic nerve head alignment methods of normal eyes in C57BL/6J mice.
Methods
Ocular dimensions and refractive development were measured on postnatal days P21 (n = 10), P28 (n = 15), and P35 (n = 8). The Purkinje image-based alignment (P1) was determined by a photorefractor and aligned perpendicular to the corneal apex using spectral domain optical coherence tomography (SD-OCT). In comparison to the optic nerve head (ONH) alignment due to the lack of fovea in mice retina. Variance analysis, regression analysis and Bland‒Altman analysis were performed to compare differences between alignment methods and replication by another operator.
Results
Mice developed hyperopic ametropia under normal visual conditions. The photorefractor measured a technical variation of 3.9 D (95% CI, n = 170, triplicates). Bland-Altman analysis revealed a shorter (mean ± SD) axial length (-26.4 ± 18.1 µm) and vitreous chamber depth (-39.9 ± 25.4 µm) in Purkinje image-based alignment. Significant difference in the relative growing trend in VCD (linear regression, p = 0.02), relatively stable and shortening when measured with ONH alignment from postnatal age 21 to 35 days.
Conclusions
SD-OCT allowed precise in-vivo ocular dimension measurement and segmentation. A significantly shorter AL and VCD were observed in Purkinje image based (P1) alignment compared to ONH method, highlighting the importance of alignment methods in optical based technique that may introduce false positive axial elongation in myopia research. Axial length has better consistency over VCD for the evaluation of axial elongation.
CodePrompt: Improving Source Code-Related Classification with Knowledge Features through Prompt Learning
Authors: Ma Yong , Luo Senlin , Shang Yu-Ming , Zhang Yifei , Li Zhengjun 
Published: October 2023

Abstract

Researchers have explored the potential of utilizing pre-trained language models, such as CodeBert, to improve source code-related tasks. Previous studies have mainly relied on CodeBert's text embedding capability and the '[CLS]' sentence embedding information as semantic representations for fine-tuning downstream source code-related tasks. However, these methods require additional neural network layers to extract effective features, resulting in higher computational costs. Furthermore, existing approaches have not leveraged the rich knowledge contained in both source code and related text, which can lead to lower accuracy. This paper presents a novel approach, CodePrompt, which utilizes rich knowledge recalled from a pre-trained model by prompt learning and an attention mechanism to improve source code-related classification tasks. Our approach initially motivates the language model with prompt information to retrieve abundant knowledge associated with the input as representative features, thus avoiding the need for additional neural network layers and reducing computational costs. Subsequently, we employ an attention mechanism to aggregate multiple layers of related knowledge for each task as final features to boost their accuracy. We conducted extensive experiments on four downstream source code-related tasks to evaluate our approach and our results demonstrate that CodePrompt achieves new state-of-the-art performance on the accuracy metric while also exhibiting computation cost-saving capabilities.
A patient-centered comparative effectiveness research study of culturally appropriate options for diabetes self-management
Authors: Page-Reeves Janet , Murray-Krezan Cristina , Burge Mark , Mishra Shiraz , Regino Lidia , Bleecker Molly , Rodriguez Daniel Perez , McGrew Hannah Cole , Bearer Elaine L. , Erhardt Erik 
Published: October 2023

Abstract

This project compared the effectiveness of two evidence-based models of culturally competent diabetes health promotion: The Diabetes Self-Management Support Empowerment Model (DSMS), and The Chronic Care Model (CCM). Our primary outcome was improvement in patient capacity for diabetes self-management as measured by the Diabetes Knowledge Questionnaire (DKQ) and the Patient Activation Measure (PAM). Our secondary outcome was patient success at diabetes self-management as measured by lower A1c values and depression scores using the PHQ-9. We also gathered data on the cultural competence of the program using the Consumer Assessment of Healthcare Providers and Systems Cultural Competence Set (CAHPS-CC). We compared patient outcomes in two sites in Albuquerque, New Mexico, that serve a large population of Latino diabetes patients from low-income households. Participants were enrolled as dyads—a patient participant (n=226) and a social support participant (n=226). Outcomes over time and by program were analyzed using longitudinal linear mixed modeling, adjusted for patient participant demographic characteristics and other potential confounding covariates. Secondary outcomes were also adjusted for potential confounders. Interactions with both time and program helped to assess outcomes. This study did not find a difference between the two sites with respect to the primary outcome measures and only one of the three secondary outcomes showed differential results. The main difference between programs was that depression decreased more for CCM than for DSMS. An exploratory, subgroup analysis revealed that at CCM, patient participants with a very high A1c (>10) demonstrated a clinically meaningful decrease in A1c. However, given the higher cultural competence rating for the CCM, statistically significant improvement in depression, and the importance of social support to the patients, results suggest that a culturally and contextually situated diabetes self-management and education program design may deliver benefit for patients, especially for those patients with high A1c levels.