bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Low-Dose Ketamine Infusion in the Intensive Care Unit on Postoperative Opioid Consumption and Traumatic Memories After Hospital Discharge: A Randomized Controlled Trial
Authors: Kitisin Nuanprae , Raykateeraroj Nattaya , Hemtanon Nattachai , Kamtip Piyawuth , Thikom Napat , Azimaraghi Omid , Piriyapatsom Annop , Chaiwat Onuma , Eikermann Matthias , Wongtangman Karuna 
Published: February 2025

BACKGROUND:
Low-dose ketamine may have an opioid-sparing effect in critically ill patients but may also predispose them to traumatic memories. We evaluated the effects of low-dose ketamine infusion in the intensive care unit (ICU) on fentanyl consumption and traumatic memories after hospital discharge.

METHODS:
This randomized, double-blind, controlled trial was conducted at a university-based surgical ICU. 118 adult patients who were admitted to the ICU after noncardiac, nonneuro, nontrauma surgery between March 2019 and May 2021 were randomized to receive ketamine 1.5 µg/kg/min (n = 60) or placebo (n = 58). Fentanyl was given to achieve pain control (10-point numerical rating scale pain score [NRS] < 4) and sedation control (Richmond Agitation and Sedation Scale [RASS] level between −2 and 0). A secondary study was conducted by a telephone interview after ICU discharge using the Thai version of the posttraumatic stress disorder (PTSD) questionnaire to evaluate signs and symptoms of PTSD and traumatic memories to the time spent in the ICU.

RESULTS:
24-hour fentanyl consumption was lower in patients who received ketamine compared with placebo (399 µg [95% confidence interval {CI}, 345–454] vs 468 µg [95% CI, 412–523], difference −68 µg; 95% CI, −67 to −69; P = .041); RASS and NRS scores did not differ between the 2 groups. Exploratory effect modification analysis suggested that the opioid-sparing effect of ketamine may be more relevant in patients with intraabdominal surgery (P-for-interaction = 0.012, difference, −177 µg; 95% CI, −204 to −149 µg; P = .001). No acute adverse effects of ketamine were observed. The secondary study included the information from 91 patients from the primary study. Long-term follow-up data was available for 45 patients (23 in the control group, 22 in the ketamine group), and the evaluations were taken 43 ± 8 months after ICU discharge. In this secondary study, ketamine use was associated with a higher incidence of frightening and delusional memories of critical illness and ICU treatment (65% vs 41%, P = .035).

CONCLUSIONS:
Low-dose ketamine is associated with a small but statistically significant reduction (15%) of postoperative opioid consumption in the ICU. Our secondary study revealed that patients who received low-dose ketamine during fentanyl-based postoperative pain therapy in the ICU recalled more frightening and delusional memories after ICU discharge.
Building bridges: allyship as a catalyst for gender diversity and inclusion in experimental biology communities
Authors: Schwaner M. Janneke , Keplinger Ksenia 
Published: February 2025

ABSTRACT
Diversity drives innovation and creativity, directly contributing to scientific excellence. However, achieving equity in academia, including in experimental biology fields such as biomechanics and comparative physiology, remains a significant challenge, with women and other historically marginalized groups underrepresented, especially in more senior roles. When considering gender, the disparity is often linked to difficulties in balancing family responsibilities with demanding careers, along with lower ‘academic visibility’, as evidenced by fewer professional awards for women scientists. Many successful women who balance career and family keep their family lives private, making these aspects invisible to early career scholars, and thus depriving them of role models. To help close the gender gap, in this Perspective, we propose 10 actionable strategies for scholars at all career stages to promote gender diversity and inclusion through active allyship. Although we focus on gender diversity, these strategies can be broadly applied to harness the benefits of other diversity dimensions (e.g. age or ethnicity). We argue that embracing allyship benefits individual scientists, their research groups, the quality of their research, the broader research community and society at large by enhancing collective scientific output and inspiring the next generation of scientists.
Η αξιοποίηση του Ψηφιακού Δράματος στην εκπαιδευτική διαδικασία: ενίσχυση του ρόλου του/της μαθητή/τριας
Authors: Καραντζούλη Αιμιλία 
Published: February 2025

Το παρόν επιστημονικό άρθρο αποτελεί απόσπασμα από τη διδακτορική διατριβή της γράφουσας με τίτλο «Το Ψηφιακό Δράμα και η Αξιοποίησή του στην Εκπαιδευτική Διαδικασία», που εκπονήθηκε στο Παιδαγωγικό Τμήμα Δημοτικής Εκπαίδευσης ΕΚΠΑ. Επιδιώκεται μέσα από την ενδελεχή μελέτη της διεθνούς βιβλιογραφίας η τεκμηρίωση της ενίσχυσης του ενεργού ρόλου που είναι σε θέση να διαδραματίσουν οι μαθητές/τριες ‒στο πλαίσιο της μαθητοκεντρικής προσέγγισης της εκπαίδευσης‒ μέσα από δραστηριότητες συγκερασμού τεχνικών του Θεάτρου στην Εκπαίδευση και των νέων τεχνολογιών. Ιδιαίτερη έμφαση δίνεται σε κάθε περίπτωση στην έννοια και τη λειτουργία του «ρόλου» στο συγκεκριμένο πλαίσιο. Πραγματοποιείται ανάλυση της δυνατότητα εξερεύνησης της ταυτότητας του μαθητή μέσα από τις δραστηριότητες της υβριδικής μορφής του Ψηφιακού Δράματος και, τέλος, γίνεται αναφορά στην αισθητική καλλιέργεια που μπορεί να επιτευχθεί για το μαθητικό δυναμικό μέσω των αντίστοιχων δραστηριοτήτων. Το άρθρο επιδιώκει να αναδείξει τη μεγάλη δυναμική, καθώς και τα οφέλη που είναι δυνατόν να επιτευχθούν, θέτοντας παράλληλα ερωτήματα και αφορμές για σκέψη και προβληματισμό.
Από τα θεραπευτικά στα καλλιτεχνικά-πολιτικά παραδείγματα: Οι ιστορικά διαμορφωμένες διαστάσεις της τέχνης των αναπήρων και το ελληνικό πολιτισμικό πλαίσιο
Authors: Κολτσίδα Μαρία 
Published: February 2025

Η τέχνη που αφορά ανάπηρα άτομα και καλλιτέχνες αποτελεί ένα πεδίο που σταδιακά προσελκύει το ενδιαφέρον ακαδημαϊκών, ερευνητών, καλλιτεχνών και πολιτιστικών οργανισμών στο ελληνικό πλαίσιο. Η σχετικά περιορισμένη ωστόσο θεωρητική και ερευνητική κάλυψη του πεδίου επιτάσσει τη διερεύνηση των διαφορετικών τάσεων που σχετίζονται με τις τέχνες, και ιδιαίτερα το θέατρο και τα ανάπηρα άτομα. Στο πρώτο μέρος της παρούσας μελέτης, διερευνώνται οι διαφορετικές πρακτικές τέχνης που αφορούν ανάπηρα άτομα και καλλιτέχνες, μέσα από συγκεκριμένες −ιστορικά διαμορφωμένες− διαστάσεις. Στο δεύτερο μέρος συζητείται η σχετική έρευνα στο πεδίο και η διάρθρωση της καλλιτεχνικής πρακτικής και εκπαίδευσης των αναπήρων στον ελληνικό πολιτιστικό χώρο. Μέσα από τη θεωρητική ανάλυση των παραπάνω δεδομένων, η μελέτη επιχειρεί να συζητήσει τους τρόπους με τους οποίους οι −ιστορικά διαμορφωμένες− διαστάσεις στην τέχνη που αφορά ανάπηρα άτομα και καλλιτέχνες διαπλέκονται και σχετίζονται με την καλλιτεχνική πρακτική και εκπαίδευση των αναπήρων στον ελληνικό χώρο.
«Δημιουργώντας χώρο ανάμεσα στους Πολιτισμούς»: Η εμπειρία τού να δουλεύεις μαζί με άλλους
Authors: Κακουδάκη Tζωρτζίνα 
Published: February 2025

Αυτό το εκπαιδευτικό πρόγραμμα ανταλλαγής έχει ως στόχο να φέρει κοντά σπουδαστές θεάτρου και δραματικών σχολών, ώστε να καθιερωθούν τρόποι με τους οποίους η θεατρική εκπαίδευση και το θέατρο ως τέχνη του θεάματος μπορούν να δημιουργήσουν έναν νέο διάλογο για τη μορφή και το περιεχόμενο, σε παιδαγωγικό και πολιτικό επίπεδο. Δεδομένου ότι οι θεατροπαιδαγωγοί συχνά στερούνται των δεξιοτήτων του θεάματος και οι ηθοποιοί συχνά στερούνται παιδαγωγικών δεξιοτήτων ‒ των μέσων που χρειάζονται για να κατευθύνουν το περιεχόμενο του έργου στους άλλους και την αλληλεπίδραση με το κοινό, το πρόγραμμα επικεντρώθηκε στα εξής:
 Πώς οι σπουδαστές δραματικών σχολών μπορούν να βρουν νέους τρόπους να δημιουργήσουν το περιεχόμενό τους σε κρίσιμα θέματα ‒ προσφέροντας σημαντική συμβολή στη δημιουργική σκέψη και τη δραματουργία.
 Πώς οι σπουδαστές εφαρμοσμένου θεάτρου μπορούν να επικεντρωθούν στη μεθοδολογία της παράστασης, της υποκριτικής και της εκφραστικότητας, αναπτύσσοντας δεξιότητες στη σκηνή.
Η πρόθεση του προγράμματος, το οποίο λειτουργεί σε ετήσια βάση, είναι να δημιουργήσει ένα μονοπάτι για την ενσωμάτωση της τέχνης του θεάτρου και του εφαρμοσμένου θεάτρου στην κοινωνία, ώστε ο ηθοποιός του μέλλοντος να εργάζεται εστιασμένα προς τις ανάγκες της κοινότητας όταν βρίσκεται στη σκηνή και ο θεατροπαιδαγωγός με άρτια αισθητικά καλλιτεχνικά εργαλεία όταν εργάζεται για την κοινότητα.
The Specific Dermatoses of Pregnancy
Authors: Polańska Paulina 
Published: February 2025

Introduction and purpose: Pregnancy-specific dermatoses are a group of pruritic skin disorders that arise exclusively during pregnancy or the postpartum period. They encompass four primary conditions: atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), intrahepatic cholestasis of pregnancy (ICP), and pemphigoid gestationis (PG). This review aims to provide a comprehensive analysis of their prevalence, clinical characteristics, underlying mechanisms, therapeutic strategies, and potential fetal risks.
Results: These dermatoses often present with overlapping clinical features, making accurate differential diagnosis crucial. While some pose minimal risk to the fetus, others, such as ICP and PG, are associated with significant complications, including preterm birth and stillbirth. The underlying pathophysiology remains incompletely understood, with hormonal, immunological, genetic, and environmental factors playing key roles. Treatment strategies focus primarily on symptomatic relief, with topical corticosteroids and oral antihistamines being the mainstay of therapy, while ursodeoxycholic acid is the treatment of choice for ICP.
Conclusions: A multidisciplinary approach is essential for optimal maternal and fetal outcomes. Further research is needed to better understand the mechanisms and develop more effective treatment options for these conditions.
Trading Volume Manipulation and Competition Among Centralized Crypto Exchanges
Authors: Amiram Dan , Lyandres Evgeny , Rabetti Daniel 
Published: February 2025

How competition affects manipulation by firms of information about important attributes of their products and how such information manipulation impacts firms’ short-term and long-term performance are open empirical questions. We use a setting that is especially suitable for answering these questions—centralized crypto exchanges, on which information manipulation takes the form of inflated trading volume. We find that static and dynamic competition measures are positively associated with volume inflation, indicating that competition may lead to increased information manipulation. Exchanges that manipulate volume obtain short-run benefits but are punished in the long run, consistent with the trade-off between short-lived increases in rents and future losses because of damaged reputation. This paper was accepted by Agostino Capponi, finance. Funding: The authors thank the Israel Science Foundation [Grant 2225/21], the Coller School of Management Blockchain Research Institute, the Henry Crown Institute for Business Research in Israel, and the Cornell Fintech Initiative for financial support. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02903 .
Further Characterizing the Within-Field Variability of Watermark Soil Water Sensor Data Over Multiple Site-Years
Authors: Venishetty Vivek , Lo Tsz Him , Conger Stacia L. Davis , Rix Jacob , Yanes Buezo Robert F. , Gholson Drew M. 
Published: February 2025

HighlightsEarly in the season, the variability among Watermark sensor replicates increased with drying and decreased with wetting.Later in the season, the variability among Watermark sensor replicates exhibited the opposite trend at deeper depths.The variability among Watermark sensor replicates was generally highest at intermediate soil water status.Preferential flow reduced the precision of irrigation scheduling using Watermark sensors.Abstract. The adoption of granular matrix sensors to trigger irrigation has been shown to improve agricultural water management. Yet because soil moisture is variable, the use of a single sensor set per irrigation system might be detrimental to precise scheduling. The goal of this study was to assess soil water tension variation within fields in order to characterize the uncertainty of sensor-based irrigation scheduling. The study examined data from multiple Watermark 200SS sensor sets in four soybean fields that differed in soil texture and irrigation practices (rainfed or furrow irrigated). Across depths and years, the results revealed that, earlier in the growing season, variability increased during drying cycles and decreased during wetting events. The opposite tendency emerged later, where variability decreased during drying cycles and increased during wetting events. Such temporal patterns remained similar when variability was analyzed in terms of volumetric water content instead. However, peaks in variability were more pronounced, and maximum variability was observed at intermediate volumetric water content. These nuanced insights into variability dynamics will inform ongoing efforts to refine sensor-based irrigation scheduling in loams and vertisols of the Lower Mississippi River Basin. The findings and implications of this study may also inform the interpretation of soil water sensor data in similar soils beyond this region, supporting sustainable agricultural water management globally. Keywords: Irrigation, Louisiana, Mississippi, Precision, Soil moisture, Soil water tension, Uncertainty, Variability, Volumetric water content.
Development and Validation of a Protocol to Determine Feed Spillage From Commercial Broiler Feeders
Authors: Rueda Martha S. , Davis Jeremiah D. , Purswell Joseph L. , Campbell Jesse C. , Edge Carson M. , Starkey Jessica D. 
Published: February 2025

HighlightsA protocol was developed to determine feed spillage from broiler pan feeders at different bird ages and feed forms.Two validation studies (14 and 42 d) showed that excreta and wood shavings can be accounted for in live bird trials.This protocol could be used in commercial broiler houses with only an internal screen and recover feed spillage &gt;90%.Abstract. Feed constitutes between 70% and 80% of total costs in commercial poultry production. As of today, it is unknown how much feed is spilled by broilers during a production flock. The objective of this project was to develop and validate a protocol to determine feed spillage from commercial broiler feeder pans. A 69 × 69 cm feed spillage capture unit consisted of a perforated top platform, internal secondary screen, and a bottom pan lined with plastic sheeting. Two experiments were conducted to simulate feed spillage rates (1%, 5%, and 10%) of broilers at 14 and 42 d of age. Feed spillage rates were applied to capture units using two internal screen approaches [no screen (NS) and secondary screen (SS)] and two corrections using an indigestible feed marker [non-corrected vs. TiO2-corrected] in a factorial arrangement. A total of 24 capture units were used to estimate recovery rates of fixed amounts of feed, wood shavings, and stone-ground mustard (as a substitute for bird excreta). Data were analyzed as a two-way ANOVA to determine interactions and main effects of screen and TiO2 correction on recovery rates. The use of a secondary screen in the capture unit aided in preventing wood shavings and simulated excreta from reaching the bottom pan. The use of TiO2 combined with the use of SS aided in segregating feed from wood shavings and simulated excreta, resulting in the best approach to determine feed spillage. When collecting feed spillage in the bottom pan using a SS followed by TiO2 correction for young birds (14 d) using crumbled feed, the percent error was within 8%, 13%, and 16% for the 1%, 5%, and 10% feed spillage rates, respectively. The larger errors for the 5% and 10% spillage rates resulted from some feed being caught by excessive wood shavings on the SS. When collecting feed spillage in the bottom pan using a SS and TiO2 correction for older birds (42 d) using pelleted feed, the percent error was within 3%, 4%, and 3% for the 1%, 5%, and 10% feed spillage rates, respectively. The proposed method can be used to accurately capture feed spillage at different broiler ages using different feed forms and to compare different commercial broiler feeders. Keywords: Broiler, Feed form, Feed spillage, Feeder.
The disenchanted fairy godmother: comparing how and why evidence-based management and public service professionals influenced policy performance in public school and active labour market policy in Denmark
Authors: Kelstrup Jesper Dahl , Jørgensen Jonas Videbæk , Hansen Magnus Paulsen 
Published: February 2025

Background:
The aspiration to use evidence to enhance the legitimacy and effectiveness of policies is widely shared but often falls short. A common explanation for failure is the presence of barriers to utilising evidence or the inadequacies of the evidence available to policy makers.

Aims and objectives:
The article examines how and why evidence-based policies sometimes fail to enhance policy performance, through a comparative analysis of evidence-based management in Danish public school and active labour market policies after 2000. The two cases are characterised by similar policy performance problems but vary in terms of evidence-based management styles and responses from public service professionals.

Methods:
The article relies on document analysis and expert interviews with civil servants and key stakeholders to explain how and why evidence-based policies fail to improve policy performance in the two cases.

Findings:
We find that evidence-based policy making did not resolve performance problems in either case, though for different reasons. In public school policy, conflict over the 2014 Public School Reform impacted negatively on its implementation despite efforts to incorporate evidence in its design. In active labour market policy, evidence-based policies were imposed on job centres and institutionalised in key performance indicators, but over time critique of processual requirements and indignified casework accumulated and contributed towards a political decision to reform job centres.

Discussion and conclusion:
We advocate for setting realistic expectations about the potential of evidence in resolving policy performance problems and caution against overstating the ‘dream’ of evidence-based policy making.
Community perspectives regarding brain-computer interfaces: A cross-sectional study of community-dwelling adults in the UK
Authors: El-Osta Austen , Al Ammouri Mahmoud , Khan Shujhat , Altalib Sami , Karki Manisha , Riboli-Sasco Eva , Majeed Azeem 
Published: February 2025

Background
Brain-computer interfaces (BCIs) represent a ground-breaking advancement in neuroscience, facilitating direct communication between the brain and external devices. This technology has the potential to significantly improve the lives of individuals with neurological disorders by providing innovative solutions for rehabilitation, communication and personal autonomy. However, despite the rapid progress in BCI technology and social media discussions around Neuralink, public perceptions and ethical considerations concerning BCIs—particularly within community settings in the UK—have not been thoroughly investigated.

Objective
The primary aim of this study was to investigate public knowledge, attitudes and perceptions regarding BCIs including ethical considerations. The study also explored whether demographic factors were related to beliefs about BCIs increasing inequalities, support for strict regulations, and perceptions of appropriate fields for BCI design, testing and utilization in healthcare.

Methods
This cross-sectional study was conducted between 1 December 2023 and 8 March 2024. The survey included 29 structured questions covering demographics, awareness of BCIs, ethical considerations and willingness to use BCIs for various applications. The survey was distributed via the Imperial College Qualtrics platform. Participants were recruited primarily through Prolific Academic’s panel and personal networks. Data analysis involved summarizing responses using frequencies and percentages, with chi-squared tests to compare groups. All data were securely stored and pseudo-anonymized to ensure confidentiality.

Results
Of the 950 invited respondents, 846 participated and 806 completed the survey. The demographic profile was diverse, with most respondents aged 36–45 years (26%) balanced in gender (52% female), and predominantly identifying as White (86%). Most respondents (98%) had never used BCIs, and 65% were unaware of them prior to the survey. Preferences for BCI types varied by condition. Ethical concerns were prevalent, particularly regarding implantation risks (98%) and costs (92%). Significant associations were observed between demographic variables and perceptions of BCIs regarding inequalities, regulation and their application in healthcare. Conclusion: Despite strong interest in BCIs, particularly for medical applications, ethical concerns, safety and privacy issues remain significant highlighting the need for clear regulatory frameworks and ethical guidelines, as well as educational initiatives to improve public understanding and trust. Promoting public discourse and involving stakeholders including potential users, ethicists and technologists in the design process through co-design principles can help align technological development with public concerns whilst also helping developers to proactively address ethical dilemmas.
Non-cancerous CT findings as predictors of survival outcome in advanced non-small cell lung cancer patients treated with first-generation EGFR-TKIs
Authors: Prakaikietikul Pakorn , Tajarenmuang Pattraporn , Losuriya Phumiphat , Ina Natee , Ketpueak Thanika , Kanthawang Thanat 
Published: February 2025

Purpose
To identify non-cancerous factors from baseline CT chest affecting survival in advanced non-small cell lung cancer (NSCLC) treated with first-generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs).

Methods
Retrospective study of 172 advanced NSCLC patients treated with first-generation EGFR-TKIs as a first-line systemic treatment (January 2012 to September 2022). Baseline CT chest assessed visceral/subcutaneous fat (L1 level), sarcopenia, and myosteatosis (multiple levels), main pulmonary artery (MPA) size, MPA to aorta ratio, emphysema, and bone mineral density. Cox regression analyzed prognostic factors at 18-month outcome.

Results
Median overall survival was 17.57 months (14.87–20.10) with 76 (44.19%) patients died at 18 months. Deceased had lower baseline BMI (21.10 ± 3.44) vs. survived (23.25 ± 4.45) (p < 0.001). Univariable analysis showed 5 significant prognostic factors: low total adiposity with/without cutoff [HR 2.65 (1.68–4.18), p < 0.001; 1.00 (0.99–1.00), p = 0.006;], low subcutaneous adipose tissue (SAT) with/without cutoff [HR 1.95 (1.23–3.11), p = 0.005; 0.99 (0.98–0.99), p = 0.005], low SAT index (SATI) with/without cutoff [1.74 (1.10–2.78), p = 0.019; 0.98 (0.97–0.99), p = 0.003], high VSR [1.67 (1.06–2.62), p = 0.026], and high MPA size with/without cutoff [2.23 (1.23–4.04), p = 0.005; 1.09 (1.04–1.16), p = 0.001]. MPA size, MPA size > 29 mm, and total adiposity ≤85 cm2 remained significant in multivariable analysis, adjusted by BMI [HR 1.14 (1.07–1.21), p < 0.001; 3.10 (1.81–5.28), p < 0.001; 3.91 (1.63–9.40), p = 0.002]. There was no significant difference of sarcopenic and myosteatotic parameters between the two groups.

Conclusion
In advanced EGFR-mutated NSCLC patients, assessing pre-treatment prognosis is warranted to predict the survival outcome and guide decision regarding EGFR-TKI therapy. Enlarged MPA size, low total adiposity, and low subcutaneous fat (lower SAT, lower SATI, and higher VSR) are indicators of poor survival. Large MPA size (>29 mm) or low total adiposity (≤85 cm2) alone predict 18-month death.