bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Results of Examination of Urine Protein Levels Dipstik Method with 6% Acetic Acid Method in Patients with Diabetes Mellitus in Area Puskesmas Baturraden II
Authors: Rahayu Feni Putri , Sulistiyowati Retno , , Sudarsono Tantri Analisawati , Rahaju Minto 
Published: October 2023

Diabetes Mellitus (DM) is a non-communicable disease and a major public health issue in Indonesia and around the world. Proteinuria caused by diabetes in the blood vessels can cause kidney damage. Diabetes can also cause nerve damage in the body. This can make urinating difficult. The pressure caused by a full bladder can harm the kidneys. If urine remains in the bladder for a longer duration, it can cause an infection due to the rapid growth of bacteria in urine with a high sugar level, even if the presence of protein in the urine has been tested in a laboratory. Objective: The study aimed to determine the difference in the results of urine protein examination with the dipstick method with the 6% acetic acid method in DM patients in the working area of Puskesmas (Public Health Center) Baturraden II. Methods: The research design used was analytic observational with a cross-sectional study. Thirty urine samples were used with purposive sampling as the sampling technique. Chi-Square Test was employed for Statistical Analysis. The results of the tests produced a significant value of 0.000 (P 0,0 5), indicating that the p-value was lower in relation to the degree of error. It could be concluded that the results of urine protein examination using the dipstick method and the 6% acetic acid method differed in DM patients.
The Relationship Between Emotional Eating And Nutritional Status In Women Of Reproductive Age In The Rimau Islands, Sumur Village
Authors: Wijaya Sofyan Musyabiq , Komala Ramadhana , Sutarto Sutarto , Nasution Syahrul Hamidi 
Published: October 2023

Background: The group of women of childbearing age is one of the phases to prepare a quality next generation. Inadequate food intake can cause problems with Chronic Energy Deficiency (KEK) in women of childbearing age. In women, the presence of depressive symptoms worsens the relationship between emotional eating and food intake. This study aimed to determine the relationship between emotional eating and the level of nutritional adequacy in women of childbearing age in the Rimau Islands, Sumur Village, South Lampung.Research Methods: This study used a cross-sectional or cross-sectional design. Researchers used the Dutch Eating Behavior Questionnaire (DEBQ), translated into Indonesian, specifically for Emotional Eating The nutritional status of young women can be seen from the Body Mass Index (BMI).Research Result: This study included 20 of the 30 respondents who attended. The statistical test for emotional eating on nutritional status (obesity) has no relationship with the p-value (0.766).Conclusion: This study concludes that there is no relationship between emotional eating and Nutritional Status.
PENGARUH PEMBERIAN COOKIES DENGAN PENAMBAHAN TEPUNG TEMPE DAN KACANG MERAH TERHADAP PENINGKATAN BERAT BADAN BALITA GIZI KURANG
Authors: Aprilia Aprilia , Sartono Sartono , Siregar Afriyana 
Published: October 2023

Masalah kekurangan gizi pada balita masih cukup tinggi, berdasarkan hasil SSGI 2021, masalah gizi kurang di Indonesia untuk kelompok umur 0-59 bulan sebesar 17% sedangkan untuk prevalensi balita gizi kurang di Sumatera Selatan sebesar 15,7% dan untuk prevalensi balita gizi kurang di kota Palembang sebesar 16,1%.
Tujuan penelitian adalah diketahui pengaruh pemberian cookies dengan penambahan tepung tempe dan kacang merah terhadap peningkatan berat badan balita gizi kurang di Wilayah Kerja Puskesmas Taman Bacaan Palembang. Metode penelitian ini adalah Quasi Experiment (Ekskperimen semu) dengan desain penelitian pretest posttest control group design. Uji statistik yang digunakan adalah uji t-dependent dan uji t-independent yang dianalisis secara univariat dan bivariat. Hasil penelitian menunjukkan Rata-rata berat badan sampel sebelum intervensi pada kelompok perlakuan yaitu 8,88 kg menjadi 9,33kg setelah intervensi. Sedangkan pada kelompok pembanding yaitu 9,66 kg menjadi 9,95 kg setelah intervensi. Hasil uji statistik (t-independent) di dapatkan p value 0,006 dapat disimpulkan bahwa ada pengaruh pemberian cookies dengan penambahanan tepung tempe dan kacang merah terhadap peningkatan berat badan balita gizi kurang di wilayah kerja Puskesmas Taman Bacaan Palembang. Disarankan kepada orang tua balita dapat melanjutkan konsumsi makanan yang tinggi kalori seperti formula cookies dengan penambahan tepung tempe dan kacang merah, sehingga dapat menaikkan berat badan balita secara bertahap.

Kata Kunci: gizi kurang, berat badan, cookies dengan penambahan tepung tempe dan kacang merah
Pola Konsumsi Makanan Sumber Asam Lemak Trans pada mahasiswa PTS Kota Bengkulu di Era Pandemi Covid 19
Authors: Halimah Halimah , Elly Nur 
Published: October 2023

Obesitas merupakan factor resiko berkembangnya Penyakit Tidak Menular (PTM). Obesitas terjadi karena penumpukan lemak akibat tidak seimbangnya antara asupan dan pengeluaran energi. Perubahan gaya hidup remaja yang cenderung lebih memilih makanan siap saji dan terbatasnya aktifitas beresiko terhadap obesitas. Masa berkembangnya Covid 19 melahirkan kebijakan adanya pembatasan aktifitas dan upaya memperbaiki asupan nutrisi untuk meminimalisir resiko penularan. Penelitian ini bertujuan untuk mengetahui pola konsumsi makanan sumber asam lemak trans pada mahasiswa Perguruan Tinggi Swasta Kota Bengkulu di era pandemi Covid 19.
Metode penelitian: Studi ini merupakan metode survey sebagai studi awal untuk melihat pola konsumsi makanan sumber asam lemak trans pada mahasiswa baru perguruan tinggi swasta kota Bengkulu di era pandemi Covid 19. Sampel berjumlah 40 mahasiswa dengan metoda purposive sampling. Pola konsumsi makanan sumber asam lemak trans menggunakan food frequency questionnaires (FFQs). Penyebaran kuisioner dibagikan secara online melalui Google form. Data diolah dan dianalisis secara deskriptif. Hasil: proporsi frekuensi konsumsi tinggi pada makanan susu dan olahannya serta ice cream dan minumannya. Makan gorengan merupakan makanan dengan proporsi frekuansi tinggi pada makanan jenis tahu dan tempe goreng, telur goreng, bakwan, ikan dan ayam goreng. Proporsi frekuensi tinggi produk HVO yang dikonsumsi adalah roti, biskuit, wafer.
Kesimpulan: produk olahan susu dan ice cream serta makanan gorengan memiliki proporsi frekuensi konsumsi yang tinggi. Konsumsi sayur >3x/hari pada sayuran hijau. Penelitian selanjutnya lebih dikembangkan pada hubungan pola konsumsi dengan status gizi remaja serta profil lipid.
Kata kunci: frekuensi konsumsi, asam lemak trans, remaja
Case Report: Multiple prolactinomas in a young man with Kallmann syndrome and familial hypocalciuric hypercalcemia
Authors: Jensterle Mojca , Janež Andrej , Vipotnik Vesnaver Tina , Debeljak Maruša , Breznik Nika , Trebušak Podkrajšek Katarina , Herman Rok , Fliers Eric , Battelino Tadej , Avbelj Stefanija Magdalena 
Published: October 2023

IntroductionThe occurrence of prolactinomas in sex hormone treated patients with central hypogonadism is extremely rare.Case presentationWe present a Caucasian male patient who was diagnosed with Kallmann syndrome (KS) at age 15 years. Testosterone treatment was started. At age 26 the patient presented with mild headache. MRI revealed two separate pituitary adenomas along with the absence of the olfactory bulbs. Given the presence of marked hyperprolactinemia (17x upper limit of the reference range) the diagnosis prolactinoma was made and treatment with cabergoline was started which resulted in a complete biochemical response and in marked reduction of both adenomas in size. Hypogonadism persisted and testosterone replacement therapy was continued. Genetic testing of genes associated with pituitary tumors, Kallmann syndrome and idiopathic hypogonadotropic hypogonadism was negative. Mild concomitant hypercalcemia in accordance with familial hypocalciuric hypercalcemia (FHH) prompted mutation analysis of the calcium receptor (CASR) gene which yielded a pathogenic inactivating variant.Discussion/conclusionThe presence of two separate prolactinomas in a patient with KS has not yet been reported in the literature. The effect of sex hormone treatment of KS patients on the possible development of prolactinoma is unknown at present. The occurance of multiple prolactinomas in our patient suggests increased susceptibility. Although CaSR is expressed in GnRH neurons in mouse brain and CaSR deficient mice have a reduced hypothalamic GnRH neuronal population, the relevance of the CASR gene variant in our patient for the KS phenotype is unclear at present.
Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study
Authors: Gerbitz Armin , Gary Regina , Aigner Michael , Moosmann Andreas , Kremer Anita , Schmid Christoph , Hirschbuehl Klaus , Wagner Eva , Hauptrock Beate , Teschner Daniel , Roesler Wolf , Spriewald Bernd , Tischer Johanna , Moi Stephanie , Balzer Heidi , Schaffer Stefanie , Bausenwein Judith , Wagner Anja , Schmidt Franziska , Brestrich Jens , Ullrich Barbara , Maas Stefanie , Herold Susanne , Strobel Julian , Zimmermann Robert , Weisbach Volker , Hansmann Leo , Lammoglia-Cobo Fernanda , Remberger Mats , Stelljes Matthias , Ayuk Francis , Zeiser Robert , Mackensen Andreas 
Published: October 2023

IntroductionAllogeneic stem cell transplantation is used to cure hematologic malignancies or deficiencies of the hematopoietic system. It is associated with severe immunodeficiency of the host early after transplant and therefore early reactivation of latent herpesviruses such as CMV and EBV within the first 100 days are frequent. Small studies and case series indicated that application of herpes virus specific T cells can control and prevent disease in this patient population.MethodsWe report the results of a randomized controlled multi centre phase I/IIa study (MULTIVIR-01) using a newly developed T cell product with specificity for CMV and EBV derived from the allogeneic stem cell grafts used for transplantation. The study aimed at prevention and preemptive treatment of both viruses in patients after allogeneic stem cell transplantation targeting first infusion on day +30. Primary endpoints were acute transfusion reaction and acute-graft versus-host-disease after infusion of activated T cells.ResultsThirty-three patients were screened and 9 patients were treated with a total of 25 doses of the T cell product. We show that central manufacturing can be achieved successfully under study conditions and the product can be applied without major side effects. Overall survival, transplant related mortality, cumulative incidence of graft versus host disease and number of severe adverse events were not different between treatment and control groups. Expansion of CMV/EBV specific T cells was observed in a fraction of patients, but overall there was no difference in virus reactivation. DiscussionOur study results indicate peptide stimulated epitope specific T cells derived from stem cell grafts can be administered safely for prevention and preemptive treatment of reactivation without evidence for induction of acute graft versus host disease.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT02227641.
Effect of anti-SARS-CoV-2 BNT162b2 mRNA vaccination on thrombin generation in children with inflammatory bowel disease
Authors: Stercel Vivien , Lóczi Linda , Kadenczki Orsolya , Nemes Éva , Nagy Béla , Hodossy-Takács Rebeka , Szabó Attila Ádám , Fagyas Miklós , Kappelmayer János , Szabó Tamás , Bagoly Zsuzsa 
Published: October 2023

BackgroundInflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC), are associated with higher thrombotic risk and enhanced thrombin generation (TG) in adults. Despite encouraging data reporting vaccine safety and low IBD flare rates in adults with IBD, vaccine hesitancy was demonstrated to be high in families of children with IBD. We aimed to find out whether TG is increased in children with IBD as compared to healthy controls and whether TG parameters show significant changes following SARS-CoV-2 mRNA vaccination.Patients and methodsIn this observational case-control study, 38 children with IBD (CD:18, UC: 20) aged 12-18 years and 62 healthy age-and sex-matched children were enrolled. Blood was collected before the first dose and 2-6 weeks after the second dose of BNT162b2 (Pfizer-BioNTech) mRNA vaccine dose. Blood cell counts, fibrinogen, inflammatory markers (hsCRP, ferritin), anti-SARS-CoV-2 antibody levels were investigated, TG assay was carried-out using platelet-poor plasma. Detailed clinical parameters including disease activity scores (PUCAI, PCDAI) were registered pre-and post- vaccination. A guided questionnaire was used to collect data on adverse reactions (AEs) post- vaccination.ResultsBaseline TG parameters did not differ between patients and controls. Endogenous thrombin potential showed a significant positive correlation with markers of inflammation and with PCDAI. Inflammatory parameters and TG did not increase in patients and controls post-vaccination. Vaccination significantly increased antibody levels in all three investigated groups, but post-vaccination anti-SARS-CoV-2 S IgG/IgM levels were below the 5th percentile value of healthy children in more than one third of patients. Those receiving TNFα inhibitor therapy presented significantly lower SARS-CoV-2 S IgG/IgM levels as compared to patients on other immunosuppressive regimens. Systemic AEs did not differ between patients and controls while lower rate of local symptoms was found post-vaccination in children with IBD. Only 2 IBD flares were detected 2-6 weeks after the second dose of vaccination.ConclusionOur study is the first to support the safety and efficacy of anti-SARS-CoV-2 BNT162b2 vaccination in children with IBD with detailed pre-and post-vaccination laboratory data including TG. Results of this study may further increase confidence and reduce vaccine hesitancy in caretakers of pediatric IBD patients.
Study of the effect of Lactobacillus crispatus FSCDJY67L3 on Helicobacter Pylori eradication: a double-blind randomized controlled clinical trial
Authors: Hong Qing , Wang Jidong , Zhang Huayue , Liu Xiaoming , Liu Zhenmin 
Published: October 2023

Helicobacter pylori (H. pylori) is a gram-negative bacterium exhibiting high pathogenicity. Traditional antibiotic treatments are considered ineffective as the H. pylori resistance has increased. Recently, a quadruple therapy strategy of probiotics and antibiotics to eliminate H. pylori was proposed. Probiotics play a therapeutic role as supplements in this process. The present research screened a probiotic strain (Lactobacillus crispatus FSCDJY67L3) that co-aggregates strongly with H. pylori. L. crispatus FSCDJY67L3 was demonstrated to significantly reduce H. pylori load (14C breath test) in clinical trials with H. pylori-positive patients. The Gastrointestinal Symptom Rating Scale (GSRS) score decreased, indicating improvement in the gastrointestinal discomfort of patients. Furthermore, L. crispatus FSCDJY67L3 showed no change in the structure of the intestinal flora of patients. Routine blood indices and blood biochemical indices related to liver and kidney function were also not affected in the patients. Therefore, L. crispatus FSCDJY67L3 may be used clinically as a supplement for the treatment of H. pylori.Clinical Trial Registrationhttps://www.chictr.org.cn/, Chinese Clinical Trial Registry (ChiCTR2100053710).
Insights into the influence of physicochemical parameters on the microbial community and volatile compounds during the ultra-long fermentation of compound-flavor Baijiu
Authors: Cheng Wei , Chen Xuefeng , Lan Wei , Liu Gengdian , Xue Xijia , Li Ruilong , Pan Tianquan , Li Na , Zhou Duan , Chen Xingjie 
Published: October 2023

IntroductionWhile the variation in physicochemical parameters, microbial communities, metabolism, composition, and the proportion of volatile components in fermented grains (FG) affect final Baijiu quality, their complex interactions during the ultra-long fermentation of compound-flavor Baijiu (CFB) are still poorly understood.MethodsIn this study, amplicon sequencing was used to analyze the microbial community, and headspace solid-phase microextraction-gas chromatography–mass spectrometry (HS-SPME-GC–MS) was used to analyze the volatile components in FG during ultra-long fermentation of CFB. The relationships between the dominant microbial communities, physicochemical parameters, and volatile components were analyzed using redundancy analysis and network analysis.ResultsDuring ultra-long fermentation, bacterial diversity was initially higher than during the mid and late stages. Fungal diversity in the mid stages was higher than that initially and later in the process. A total of 88 volatile components, including six alcohols, 43 esters, eight aldehydes and ketones, 13 acids, and 18 other compounds were detected in FG. Starch and reducing sugars in FG strongly affected the composition and function of bacterial and fungal communities. However, acidity had little effect on the composition and function of the bacterial flora. Lactobacillus, Bacillus, Weissella, and Pichia were the core microbial genera involved in metabolizing the volatile components of FG.DiscussionWe provide insights into the relationships and influences among the dominant microbial communities, physicochemical parameters, and volatile components during ultra-long fermentation of CFB. These insights help clarify the fermentation mechanisms of solid-state fermentation Baijiu (SFB) and control and improve the aroma quality of CFB.
Efficacy of cupping therapy on pain outcomes: an evidence-mapping study
Authors: Wang Liaoyao , Cai Ziling , Li Xuanlin , Zhu Aisong 
Published: October 2023

ObjectiveCupping therapy is an ancient technique of healing used to treat a variety of ailments. An evidence-mapping study was conducted to summarize the existing evidence of cupping therapy for pain-related outcomes and indicate the effect and the quality of evidence to provide a comprehensive view of what is known.MethodsPubMed, Cochrane Library, Embase, and Web of Science were searched to collect the meta-analyses investigating the association between cupping therapy and pain-related outcomes. The methodological quality was assessed by using the AMSTAR 2 tool. Significant outcomes (p &lt; 0.05) were assessed using the GRADE system. The summary of evidence is presented by bubble plots and human evidence mapping.ResultsFourteen meta-analyses covering five distinct pain-related conditions were identified and assessed for methodological quality using the AMSTAR 2, which categorized the quality as critically low (36%), low (50.0%), moderate (7%), and high (7%). In accordance with the GRADE system, no high-quality evidence was found that demonstrates the efficacy of cupping therapy for pain-related outcomes. Specifically, for neck pain, there were two moderate-quality, four low-quality, and two very low-quality evidence, while only one very low-quality evidence supports its efficacy in treating herpes zoster and one low-quality evidence for chronic back pain. Additionally, for low back pain, there were two moderate-quality, one low-quality, and four very low-quality evidence, and for knee osteoarthritis, three moderate-quality evidence suggest that cupping therapy may alleviate pain score.ConclusionThe available evidence of very low-to-moderate quality suggests that cupping therapy is effective in managing chronic pain, knee osteoarthritis, low back pain, neck pain, chronic back pain, and herpes zoster. Moreover, it represents a promising, safe, and effective non-pharmacological therapy that warrants wider application and promotion.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021255879, identifier: CRD42021255879.
Neurofeedback strategies in binge-eating disorder as predictors of EEG-neurofeedback regulation success
Authors: Wimmer Jytte , Rösch Sarah Alica , Schmidt Ricarda , Hilbert Anja 
Published: October 2023

IntroductionTreatment options such as neurofeedback (NF) that directly target the link between aberrant brain activity patterns and dysfunctional eating behaviors in binge-eating disorder (BED) are emerging. However, virtually nothing is known about mental strategies used to modulate food-specific brain activity and the associated brain-based or subjective success of specific strategies. This study firstly investigated the use of mental strategies in response to individually appetitive food cues in adults with BED and overweight or obesity based on a randomized-controlled trial providing electroencephalography (EEG)- or real-time functional near-infrared spectroscopy (rtfNIRS)-NF to BED.MethodsStrategy reports written by participants were classified with qualitative content analysis. Additionally, the mental strategies employed by theN = 23 patients who received EEG-NF targeting the reduction of fronto-central high beta activity were analyzed quantitatively through their link with subjective and EEG-NF regulation success.ResultsThe following eight categories, ordered by frequency in descending order, were found: “Behavior,” “Imagination,” “Emotion,” “Distraction,” “Thought,” “Concentration,” “Self-Talk” and “No Strategy.” Linear mixed models revealed “Imagination,” “Behavior,” and “Thought” strategies as positive predictors of EEG-NF regulation success (defined as high beta activity during regulation beneath the baseline), and “Concentration” as a negative predictor of subjective (i.e., self-reported) NF regulation success.DiscussionIn conclusion, our study offers a classification system that may be used in future studies assessing strategy use for regulating food-related responses in patients with BED and associated overweight/obesity, providing valuable information on potential benefits of specific strategies and transferability to situations outside the NF treatment.