bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing factors of abnormal bone mass in perimenopausal and postmenopausal women based on health ecology model: A cross-sectional study
Authors: He Haiyang , Yang Jialing , Wen Qian , Zhou Yaoyao , Wang Meng , Cheng Zhifeng , Li Ning , Li Yangmei , Liu Dongyang , Ren Meihong , Su Han , Tang Ling , Deng Jie , Fan Yao , Zhou Mingfang , Yu Lili , Lei Xun 
Published: January 2024

Abstract

Background
As the world's population ages, bone health has become a major public problem. The incidence of osteoporosis in women will further increase due to the decline of oestrogen after menopause. In this study, we used a health ecology model to explore the factors affecting abnormal bone mass in perimenopausal and postmenopausal women at different levels, and to provide a basis for the management and prevention of abnormal bone mass in women at this stage of life in China.
Methods
From October 2022 to September 2023, perimenopausal and postmenopausal women aged ≥ 40 years admitted to five recruited hospitals in China were recruited by purposive sampling method.Information on five levels of the health ecology model, including personal traits, behavioral characteristics, interpersonal network, working and living conditions, and policy environment was collected through structured questionnaires, and the data were analyzed using a structural equation model.
Results
Among 531 participants, 248 subjects had normal bone mass, 230 had osteopenia and 53 had osteoporosis. The results of the structural equation model showed that personal traits had the strongest direct positive effect on bone mass abnormality (β = 0.417, P < 0.05); behavioural characteristics had a direct positive effect on bone mass abnormality (β = 0.253, P < 0.05); interpersonal network had a direct negative effect on bone mass abnormality (β=-0.268, P < 0.05) and an indirect effect through personal traits; living conditions have a direct negative effect on bone mass abnormalities (β=-0.248,P < 0.05), and indirect effect through behavioural traits and interpersonal network; medical insurance can have an indirect effect on bone mass abnormalities through living conditions and interpersonal network.
Conclusion
Currently, the prevalence of abnormal bone mass in perimenopausal and postmenopausal women is high in China. Combined with the health ecology model, we found that personal characteristics and unhealthy behavior characteristics are risk factors for abnormal bone mass, higher social support and living conditions are protective factors for abnormal bone mass, which could indirectly affect abnormal bone mass, and medical insurance can indirectly affect abnormal bone mass. Future policy recommendations for the prevention of abnormal bone mass can be based on the factors and pathways that affect abnormal bone mass in perimenopausal and postmenopausal women identified in this study, in order to reduce the incidence of abnormal bone mass and improve the quality of life of perimenopausal and postmenopausal women.
Longitudinal MRI monitoring of negative lymph node identifies prognostic diversity and therapeutic implications in nasopharyngeal carcinoma
Authors: Dai Dong-Yu , He Shui-Qing , Zhang Shu , Yang Kai-Bin , Jiang Wei , Li Ji-Bin , Liu Li-Zhi , Sun Ying , Huang Ying , Ma Jun , Xu Cheng 
Published: January 2024

Abstract

Objectives To investigate the value of negative lymph node (LNneg) in prognostic prediction and therapeutic implications in the N0 subgroup (T3–4N0M0) of locoregionally advanced nasopharyngeal carcinoma (NPC). Materials and Methods All patients in this retrospective cohort study were consecutively extracted from an NPC-specific database (N = 15,126) and treated using concurrent chemoradiotherapy (CCRT) with/without induction chemotherapy (IC) during 2009–2017. Cervical LNneg distribution was dichotomized per MRI-based features as the concentrated and dispersed types. The association of overall survival (OS) with LNneg size, distribution, and regression was investigated using Cox analysis. LNneg regression was explored from three aspects: speed, extent, and overall pattern. Results In 724 included patients (mean age: 47 +/- 11 [standard deviation], 533 men), the dispersed type of cervical LNneg had a significant higher 5-year OS than the concentrated type (95.0% vs. 89.0%;P-value = .005), which was mainly due to its smaller nodal metastasis rate (3.2% vs. 13.0%) and validated in low-infection status (albumin > 40g/L, C-reactive protein ≤ 3mg/L, lactate dehydrogenase ≤ 250U/L). IC + CCRT and CCRT with ≥ 200mg cisplatin benefited the concentrated (HR = 0.47 [95% CI = 0.22–0.98];P-value = .004) and dispersed types (HR = 0.18 [0.06–0.54];P-value = .002), respectively. IC + CCRT induced a generally greater and faster LNneg regression than CCRT. The concentrated type preferred to show an overall regression pattern than the dispersed type. Reduction in short/long axial diameter of the largest cervical LNneg of ≥ 3.0mm/4.0mm was an OS improvement indicator. Conclusion MRI-based cervical LNneg distribution and regression predicted prognosis and identified high-risk cases of the N0 patients with locoregionally advanced NPC (i.e., concentrated type) to receive IC + CCRT.
Comparative Study of Ultrasound Attenuation Analysis and Controlled Attenuation Parameter in the Diagnosis and Grading of Liver Steatosis in Non-alcoholic Fatty Liver Disease Patients
Authors: Wang Mengyun , Tang Shuzhen , Li Guoqiu , Huang Zhibin , Mo Sijie , Yang Keen , Chen Jing , Du Baishan , Xu Jinfeng , Ding Zhimin , Dong Fajin 
Published: January 2024

Abstract
Purpose
To assess the diagnostic performance of Ultrasound Attenuation Analysis (USAT) in the diagnosis and grading of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD) using Controlled Attenuation Parameters (CAP) as a reference.
Materials and Methods
From February 13, 2023, to September 26, 2023, participants underwent CAP and USAT examinations on the same day. We used manufacturer-recommended CAP thresholds to categorize the stages of hepatic steatosis: stage 1 (mild) − 240 dB/m, stage 2 (moderate) − 265 dB/m, stage 3 (severe) − 295 dB/m. Receiver Operating Characteristic curves were employed to evaluate the diagnostic accuracy of USAT and determine the thresholds for different levels of hepatic steatosis.
Results
Using CAP as the reference, we observed that the average USAT value increased with the severity of hepatic steatosis, and the differences in USAT values among the different hepatic steatosis groups were statistically significant (p < 0.05). There was a strong positive correlation between USAT and CAP (r = 0.674, p < 0.0001). When using CAP as the reference, the optimal cut-off values for diagnosing and predicting different levels of hepatic steatosis with USAT were as follows: the cut-off value for excluding the presence of hepatic steatosis was 0.54 dB/cm/MHz (AUC 0.96); for mild hepatic steatosis, it was 0.59 dB/cm/MHz (AUC 0.86); for moderate hepatic steatosis, it was 0.73 dB/cm/MHz (AUC 0.81); and for severe hepatic steatosis, it was 0.87 dB/cm/MHz (AUC 0.87).
Conclusion
USAT exhibits strong diagnostic performance for hepatic steatosis and shows a high correlation with CAP values.
Low BMI Demonstrates Satisfactory Specificity for Diagnosing Malnutrition and is Associated with Longer Hospitalization in Patients with Gastrointestinal or Head and Neck Cancer: A Prospective Cohort Study
Authors: Soares Camilla , Stefani Giovanna , Scott Laura , Crestani Mariana , Steemburgo Thais 
Published: January 2024

Abstract

Purpose
Few studies have evaluated the individual performance of the nutritional indicators body mass index (BMI), calf circumference (CC), and handgrip strength (HGS) for the diagnosis of malnutrition in the cancer setting. We aimed to evaluate the ability of these nutritional indicators to accurately diagnose malnutrition and their association with hospital length of stay (LOS) in patients with cancer.
Methods
This cohort study prospectively evaluated 171 patients with gastrointestinal or head and neck cancer. Nutritional status was assessed within 48 hours of hospital admission using BMI, CC, and HGS as well as 2 reference standards: Subjective Global Assessment (SGA) and Patient-Generated SGA (PG-SGA). The accuracy of each nutritional indicator was measured by the area under the receiver operating characteristic curve (AUC), compared with the reference standards. Multiple logistic regression analysis, adjusted for confounders, was used to determine whether malnutrition was associated with LOS.
Results
Of 171 patients, 59.1% had low CC, 46.2% had low HGS, and 13.5% had low BMI. The SGA and PG-SGA scores indicated malnutrition in 57.3% and 87.1% of patients, respectively. All nutritional indicators had poor accuracy in diagnosing malnutrition (AUC < 0.70). However, compared with SGA and PG-SGA, low BMI had satisfactory specificity (> 80%) and was associated with 1.79 times higher odds of LOS ≥ 6 days. Malnutrition diagnosed by SGA and PG-SGA increased the odds of LOS ≥ 6 days by 3.60-fold and 2.78-fold, respectively.
Conclusion
Low BMI showed adequate specificity for diagnosing malnutrition and was associated with longer LOS in patients with gastrointestinal or head and neck cancer.
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Authors: Lei Ruilin , long yun , Li Qingjian , Xie Qingsheng , Ling Xiaoting , Xie Meiqing , Zhou Hui , Zhang Bingzhong 
Published: January 2024

Abstract
Background: The chemotherapy drug cisplatin is the backbone of the treatment of ovarian cancer, and patients who develop resistance to cisplatin are associated with poor survival. Circular RNA was associated with cisplatin resistance of ovarian cancer.However,the mechanism of interaction between circular RNA and cisplatin resistance of ovarian cancer remains unclear and needs to be further explored.
Methods:High-throughput sequencing analysis was performed to identify circRNA expression profiles in cisplatin-resistant ovarian cancer. Gain and loss function experiment were performed to verify the sensitivity of cisplatin in vitro and in vivo. Fluorescence in situ hybridization was performed to demonstrate the cellular location of circRNA.RNA pulldown and RNA immunoprecipitation were were performed to identify the binding protein of circRNA.
Result:We found that circ_ARHGEF28 overexpressed in some cisplatin-resistant ovarian cancer tissues and cell lines and was associated with poor PFS in ovarian cancer patients.The circ_ARHGEF28 induced cisplatin resistance in ovarian cancer in vitro and in vivo.Furthermore, circ_ARHGEF28interacted directly with MST1/2 and blocked the SARAH coiled-coil binding domains of MST1/2 to deactivate the Hippo pathway.
Conclusion:We identified a novel circular RNA circ_ARHGEF28 induced cisplatin resistance in ovarian cancer by suppressing the Hippo pathway.As a result of our findings, targeting circ_ARHGEF28 may be a potential strategy to overcome cisplatin resistance in ovarian cancer.
Invariances in relations between the rates of mortality and aging captured by a generalization of the Gompertz-Makeham law: Lessons from Caucasus
Authors: Golubev A. 
Published: January 2024

Abstract

Among scarce biological relations qualifiable as laws, the Gompertz-Makeham law (GML) stands out being directly related to life-and-death issues. GML may be written as: -[dn(t)/n(t)]/dt≡µ(t) = e^(-v + γt) + C = e^(-v)*e^(gt) + C = µ0*e^(gt) + C, where µ(t) is mortality rate (MR), v captures vitality (resistance to mortality), g captures aging-associated v decrease, µ0 = 1/e^v is the initial MR, and C captures the MR part attributable to external (background) hazards irresistible at any age. GML status is questionable since, upon the common assumptions that vitality decreases linearly and C is constant, MR-vs-age trajectories violate GML, especially at later ages. A generalized GML (GGML) µ(t) = C(t)+µ0*e^[f(t)] suggests that MR increases exponentially IF vitality decreases linearly, i.e. IF f(t) = gt, and C = 0. GGML produces µ(t) changes from any vitality changes by exponentiation and, from any background hazardousness changes, in a linear way. Thus, f(t) may be deduced from µ(t), provided C(t) is treated properly. Based on this, it may be shown that a hump of the biological aging rate revealed through the lens of GGML at ages 65 to 90 years in low C(t) countries featuring high life expectancies may be discerned also in high C(t) countries by taking into account that C(t) there is increased mostly in the middle of age span, as in the North Caucasus and some other Russian Federation regions. Thus, GGML captures relational invariants inherent in the animate nature and discernable even beneath such multifactorial phenomena as human mortality and its such diverse manifestations as mortality kinetics. These invariants constrain advances in human life expectancy.
A simple and practical method to increase the infectivity of wild isolates of Plasmodium falciparum to mosquito vectors
Authors: Ouattara Seydou Bienvenu , Hien Domonbabele F. D. S. , Nao Ekôbié T. , Paré Prisca S. L. , Guissou Edwige , Cohuet Anna , Morlais Isabelle , Yerbanga Rakiswendé S. , Dabiré Kounbobr R. , Ouédraogo Jean Bosco , Mouline Karine , Lefèvre Thierry 
Published: January 2024

Abstract

Background
The direct membrane feeding assay (DMFA), whereby gametocyte-infected blood is collected from human donors and from which mosquitoes feed through a membrane, is proving essential for assessing parameters influencing Plasmodium transmission potential in endemic countries. The success of DMFAs is closely tied to gametocyte density in the blood, with relatively high gametocytemia ensuring optimal infection levels in mosquitoes. As transmission intensity declines with control efforts, occurrence of low gametocyte densities is increasing, posing a limitation to studies relying on the experimental infection of large numbers of mosquitoes with natural isolates of Plasmodium. A simple, field-applicable method is presented for improving parasite infectivity by concentrating Plasmodium falciparum gametocytes.
Methods
Anopheles gambiae received one of the following 5 blood treatments through DMFA: (i) whole blood (WB) samples from naturally-infected donors; (ii) donor blood whose plasma was replaced with the same volume of Plasmodium-naive AB + serum (1:1 control); (iii) plasma replaced with a volume of malaria-naïve AB + serum equivalent to half (1:1/2), or to a quarter (1:1/4), of the initial plasma volume; and (v) donor blood whose plasma was fully removed (RBC). The experiment was repeated 4 times using 4 distinct wild parasite isolates. Seven days post-infection, a total of 1,095 midguts were examined for oocyst presence.
Results
Substituting plasma with reduced amounts (1:1/2 and 1:1/4) of Plasmodium-naive AB + serum led to a 31% and 17% increase of the mosquito infection rate and to a 85% and 308% increase in infection intensity compared to the 1:1 control, respectively. The full removal of plasma (RBC) reduced the infection rate by 58% and the intensity by 64% compared to the 1:1 control. Reducing serum volumes (1:1/2; 1:1/4 and RBC) had no impact on mosquito feeding rate and survival when compared to the 1:1 control.
Conclusions
Concentrating gametocytic blood by replacing natural plasma by lower amount of naive serum can enhance the success of mosquito infection. In an area with low gametocyte density, our simple and practical method of parasite concentration can facilitate studies on human-to-mosquito transmission such as the evaluation of transmission blocking interventions.
Revolutionizing Neurostimulator Care: Enhancing Remote Health Monitoring through SDN-Cloud Networks
Authors: Antony Leo Prasanth Lourdu , Elangovan Uma 
Published: January 2024

Abstract

The Internet of Things (IoT) and artificial intelligence (AI) are the fastest-growing technological approaches globally. With the rising urban population, the concept of a smart city isn't new. To effectively integrate IoT and AI into remote healthcare monitoring (RHM) systems within smart cities, we must have a comprehensive grasp of smart city frameworks. Our proposed model focuses on gathering data from an auricular therapy device, a neurostimulator that provides non-invasive stimulation to the outer ear. This device communicates via Bluetooth, allowing data exchange between the patient's and doctor's phones. After collecting the brain signal data, it's processed to eliminate noise and is normalized. This data is then classified using the adaptive fuzzy based Bayesian metasalp neural network (AFBBMNN) combined with levy flight secure offloading analysis in Software Defined Networking (SDN). The results prominently emphasize the need for enhanced healthcare provision. This information is then relayed to doctors via a cloud-SDN module that comprises a communication phase, cloud server, and cloud database where the signals are stored. The proposed method offers promising outcomes, emphasizing its viability as an efficient tool for early neurological disease detection and treatment within a smart city healthcare framework.
Connection Between Mainland-indochina Monsoon Onset Dates and Cyclones Over Andaman Sea Bay of Bengal Basin
Authors: Oo Kyaw , JONAH Kazoraa 
Published: January 2024

Abstract
This study delves into the intricate connection between Mainland Indochina Southwest Monsoon (MSWM) onset dates and tropical cyclones (TCs) over the Bay of Bengal (BOB) and Arabian Sea (ABMS). Utilizing datasets like IBTrACS, ERA5 reanalysis, and CHRIPS daily rainfall data, the research highlights the influence of TCs on monsoon onset, emphasizing sea surface temperatures and rainfall intensity. The bimodal distribution of cyclones during early and late-onset years is noted, characterizing MSWM onset by the April-June TC count. Significant correlations emerge between cyclone frequency, monsoon onset dates, SST, and rainfall patterns. Cyclones impact agriculture, water resources, and disaster preparedness in monsoon-dependent regions. Employing a robust methodology, the study reveals a complex relationship between TCs and monsoon onset, with early-onset years experiencing higher TC numbers. Additionally, the research explores the impact of El Niño–Southern Oscillation (ENSO), associating positive phases with late monsoon onset and negative phases with early onset and increased rainfall. The findings underscore TCs' multifaceted role in shaping the monsoon, offering insights into intricate climate variables and cyclone dynamics in the northern Indian Ocean.
Primary amenorrheic girls with persistent hyperandrogenemia：a case report
Authors: Yang Yang , Zhang Jing , Qiao Lin 
Published: January 2024

Abstract

BackgroundHyperandrogenemia in women is most commonly associated with polycystic ovary syndrome, but is very rare due to abnormal sexual development.
Case presentationWe report a 16-year-old girl who initially visited at the Reproductive Endocrinology Unit for "primary amenorrhea" and was found to have a "naive uterus". Then uterine growth was promoted by using oral natural estrogens and progestins, followed by oral contraceptives to help breast development and inducing menstruation. However, when the patient visited one year later, the high level of serum testosterone was found by another senior physician (testosterone fluctuating from 0.828-3.91 ng /ml during the unmedicated period) in the outpatient clinic.
Therefore, many tests have been scheduled for this young woman to find the source of high level testosterone, including pelvic ultrasound to check the ovary, abdominal ultrasound to examine the adrenal gland, blood test to check the chromosome and adrenal-related hormones，MRI to examine the development of organs in the pelvis. The patient was admitted to the hospital and underwent laparoscopic exploratory surgery, testis-like tissue was found by both naked eye and pathological biopsy. The postoperative paraffin pathology report confirmed that the patient was a OT-DSD with one ovary (left) and one ovotestis (right). Testosterone decreased to 0.12 ng/ml on the first postoperative day.
Conclusions In patients with menstrual disorders who have hyperandrogenemia, even if they have normal chromosomes and normal vulvar development, the focus of the diagnosis and treatment is to find out the source and cause of androgens and to treat the cause, instead of simply using drugs to achieve the purpose of reducing androgens and inducing menstruation. Gynecologic endocrinologists and ultrasonographers should be aware of the clinical status of the presence of such rare diseases as ovotestis.
Optimal Formulation of Hybrid Polypropylene Composites Reinforced Crab Shell Flour and Rubberwood Sawdust after Immersing in Different Water Conditions for Applications in Tropical Countries
Authors: Khamtree Sriwan , Homkhiew Chatree , Sriva Chainarong , Ratanawilai Thanate , Rawangwong Surasit 
Published: January 2024

Abstract

Hybrid recycled polypropylene (rPP) composites reinforced with crab shell (CS) waste and rubberwood sawdust (RWS) were developed for applications in tropical countries. The D-optimal mixture design was applied in experiments, to determine the effects of the three main fractions including rPP, RWS, and CS on the mechanical properties after immersing in distilled water and seawater. Response Surface Methodology (RSM) was used to identify the optimal formulation that maximizes the mechanical properties of the hybrid composites. The results indicated that the mechanical properties fit best with the quadratic models. Statistical analysis revealed that all the models had a less p-value than 0.05 (α = 0.05) and could accurately predict the mechanical properties. Moreover, these factors negatively affected the mechanical properties whereas the CS had the highest coefficient of all the models. The mechanical properties of the hybrid composites immersed in seawater decreased significantly compared to those immersed in distilled water. Therefore, an optimal formulation of overall mechanical properties was 55.1 wt% rPP, 32.5 wt% RWS, 6.9 wt% CS, 4.0 wt% maleic anhydride-grafted polypropylene, 0.5 wt% ultraviolet stabilizer, and 1.0 wt% lubricant with a desirability score of 0.976. Finally, the optimal formulation of the hybrid composites has been presented and is expected to be applied for applications and waste management from natural materials. Keywork: Hybrid composites, Crab shell, Rubberwood sawdust, Mechanical Properties, Optimal formulation