bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Variability in Meter-Scale Laboratory CO2 Injections in Faulted Geometries
Authors: Haugen Malin , Saló-Salgado Lluís , Eikehaug Kristoffer , Benali Benyamine , Both Jakub W. , Storvik Erlend , Folkvord Olav , Juanes Ruben , Nordbotten Jan Martin , Fernø Martin A. 
Published: January 2024

AbstractCarbon, capture, and storage (CCS) is an important bridging technology to combat climate change in the transition toward net-zero. The FluidFlower concept has been developed to visualize and study CO2 flow and storage mechanisms in sedimentary systems in a laboratory setting. Meter-scale multiphase flow in two geological geometries, including normal faults with and without smearing, is studied. The experimental protocols developed to provide key input parameters for numerical simulations are detailed, including an evaluation of operational parameters for the FluidFlower benchmark study. Variability in CO2 migration patterns for two different geometries is quantified, both between 16 repeated laboratory runs and between history-matched models and a CO2 injection experiment. The predicative capability of a history-matched model is then evaluated in a different geological setting.
Assessment of an effective quantitative model with multi-criteria decision-making method for sustainable campus
Authors: Aksoy Onur , Demir Sara , Ersoz Nazli Deniz , Gokkaya Merve Dilman 
Published: January 2024

AbstractSustainability is a current topic in public open green spaces such as university campuses. In order to ensure the sustainability of the campus areas, it is necessary to determine the criteria for the sustainable campus landscape. Bursa Uludağ University Gorukle Campus in Bursa was chosen as the study area in this research. The aim of the study is to identify suitable sustainable campus criteria with a focus on landscape and to prioritize appropriate sustainable campus strategies determined according to these criteria. In this context, first, field studies and literature research were carried out. Second, sustainable campus criteria were classified as criteria and section. The section was then divided into credit. All these credits were ranked according to their priorities. Analytic hierarchy process, one of the multi-criteria decision-making methods, was used while ranking. According to the result of the criteria, planting landscape components were determined to be more important than structural landscape components. Among the section, the transport category was found as the highest priority criterion. The use of vegetable wastes as compost was also determined as the most important criterion among all credits. The method and findings of this research may set an example for determining priorities of the sustainable campus criteria in Turkey and developing countries with a participatory management approach.
Analysis of Wave-Induced Forces on a Floating Rectangular Box with Analytical and Numerical Approaches
Authors: Mohapatra Sarat Chandra , da Silva Bispo Iuri Baldaconi , Guo Yuchan , Guedes Soares C. 
Published: January 2024

AbstractA three-dimensional mathematical hydrodynamic model associated with surface wave radiation by a floating rectangular box-type structure due to heave, sway, and roll motions in finite water depth is investigated based on small amplitude water wave theory and linear structural response. The analytical expressions for the radiation potentials, wave forces, and hydrodynamic coefficients are presented based on matched eigenfunction expansion method (MEFEM). The correctness of the analytical results of wave forces is compared with the construction of a numerical model using the open-source boundary element method code NEMOH. In addition, the present result is compared with the existing published experimental results available in the literature. The effects of the different design parameters on the floating box-type rectangular structure are studied by analyzing the vertical wave force, horizontal wave force, torque, added mass, and damping coefficients due to the heave, sway, and roll motions, and the comparison analysis between the forces is also analyzed in detail. Further, the effect of reflection and transmission coefficients by varying the structural width and drafts are analyzed.
Advanced Therapies for Inflammatory Bowel Disease: Navigating Payor and Financial Challenges
Authors: Whitmire Natalie , Schlueter Michelle , Kirkpatrick Melissa 
Published: January 2024

Abstract
Purpose of Review
In the United Sates the cost of managing Crohn’s disease and ulcerative colitis, the two most common inflammatory bowel diseases, is a major factor that can alter the course of treatment. The increasing use of advanced therapies such as biologics and oral small molecules is a driver of these costs. Many IBD providers find navigating the payor and non-insurance cost assistance processes to be a significant challenge in care management. We aim to clarify these processes and provide an outline for success.

Recent Findings
Insurance companies use various processes to manage medication costs and while they may not ultimately be cost-effective, the processes have continued and are increasingly complex. This complexity has led to measurable delays in care and negative outcomes.

Summary
With a deeper understanding of payor and non-insurance cost-assistance processes we have developed a workflow for navigating the use of advanced therapies in the treatment of IBD.
Pathways from cognitive flexibility to academic achievement: mediating roles of critical thinking disposition and mathematics anxiety
Authors: Gökçe Semirhan , Güner Pınar 
Published: January 2024

AbstractThe purpose of this study is to examine the mediating roles of critical thinking disposition and mathematics anxiety between cognitive flexibility and academic achievement. A cross-sectional study was held to observe and compare path coefficients among latent and observed variables across 662 university students studying elementary mathematics education. In concur with grade point average scores, Cognitive Flexibility Scale, UF/EMI Critical Thinking Disposition Instrument and Math Anxiety-Apprehension Survey scores were utilized for structural equation modeling analyses. The results of this study indicated that freshman students experience the greatest impact from cognitive flexibility on academic achievement, while sophomores experience the least impact. Additionally, with the exception of the model for sophomore students, the mediating effects of the critical thinking disposition between cognitive flexibility and academic achievement were positive and statistically significant. Additionally, none of the models’ estimations of how mathematics anxiety would mediate between cognitive flexibility and academic achievement were statistically significant. Last but not least, for junior students only positive and statistically significant mediating effects of critical thinking disposition and mathematics anxiety between cognitive flexibility and academic achievement were found. This study put forth evidence to investigate cognitive flexibility, critical thinking disposition and math anxiety in higher education and to show the total, direct and mediating effects on academic achievement.
Global Variability of Phytoplankton Carbon and Non‐Algal Particles From Ocean Color Data Based on a Photoacclimation Model
Authors: Yang Guo , Bellacicco Marco , Organelli Emanuele , Xing Xiaogang 
Published: January 2024

AbstractPhytoplankton is the most important primary producer in the ocean, owing to its pivotal role at the base of the food chain and in the ocean carbon cycle. To better estimate ocean productivity, the retrieval of accurate observations of phytoplankton carbon (Cphy) biomass from ocean color satellites is of the utmost importance. When Cphy is retrieved using the backscattering signal generated by marine particles, the signal due to non‐algal particles—NAP (bbNAP) must be removed. However, algorithms currently used to retrieve bbNAP do not work globally, especially in the large mid‐ocean subtropical gyres. Here, we propose a new model to derive Cphy globally, including all subtropical gyres, that accounts for the estimation of phytoplankton photoacclimation when retrieving bbNAP. The new model shows more valid retrievable bbNAP coefficients than the previously published methods and values mainly around 0.0011 m−1, consistent with coefficients estimated with in situ observations. Moreover, the retrieved Cphy concentrations show a relative error of 7% with respect to in situ measured picophytoplankton carbon data. Our research indicates that the photoacclimation status of phytoplankton must be addressed to confidently retrieve bbNAP and Cphy at the global scale from ocean color measurements.
Real-world analysis of teclistamab in 123 RRMM patients from Germany
Authors: Riedhammer C. , Bassermann F. , Besemer B. , Bewarder M. , Brunner F. , Carpinteiro A. , Einsele H. , Faltin J. , Frenking J. , Gezer D. , Goldman-Mazur S. , Hänel M. , Hoegner M. , Kortuem K. M. , Krönke J. , Kull M. , Leitner T. , Mann C. , Mecklenbrauck R. , Merz M. , Morgner A. , Nogai A. , Raab M. S. , Teipel R. , Wäsch R. , Rasche L. 
Published: January 2024

AbstractTeclistamab, a B-cell maturation antigen (BCMA) × CD3 directed bispecific antibody, has shown high response rates and durable remissions in the MAJESTEC-1 trial in patients with relapsed and refractory multiple myeloma (RRMM). We retrospectively assessed efficacy and tolerability in 123 patients treated at 18 different German centers to determine whether outcome is comparable in the real-world setting. Most patients had triple-class (93%) or penta-drug (60%) refractory disease, 37% of patients had received BCMA-directed pretreatment including idecabtagene vicleucel (ide-cel) CAR-T cell therapy (21/123, 17.1%). With a follow-up of 5.5 months, we observed an overall response rate (ORR) of 59.3% and a median progression-free survival (PFS) of 8.7 months. In subgroup analyses, we found significantly lower ORR and median PFS in patients with extramedullary disease (37%/2.1 months), and/or an ISS of 3 (37%/1.3 months), and ide-cel pretreated patients (33%/1.8 months). Nonetheless, the duration of response in ide-cel pretreated patients was comparable to that of anti-BCMA naive patients. Infections and grade ≥3 cytopenias were the most frequent adverse events. In summary, we found that teclistamab exhibited a comparable efficacy and safety profile in the real-world setting as in the pivotal trial.
Longitudinal hippocampal subfield development associated with psychotic experiences in young people
Authors: O’Neill Aisling , Dooley Niamh , Roddy Darren , Healy Colm , Carey Eleanor , Frodl Thomas , O’Hanlon Erik , Cannon Mary 
Published: January 2024

AbstractHippocampal volumetric reductions are observed across the psychosis spectrum, with interest in the localisation of these reductions within the hippocampal subfields increasing. Deficits of the CA1 subfield in particular have been implicated in the neuropathophysiology of psychotic disorders. Investigating the trajectory of these abnormalities in healthy adolescents reporting sub-threshold psychotic experiences (PE) can provide insight into the neural mechanisms underlying psychotic symptoms without the potentially confounding effects of a formal disorder, or antipsychotic medication. In this novel investigation, a sample of 211 young people aged 11-13 participated initially in the Adolescent Brain Development study. PE classification was determined by expert consensus at each timepoint. Participants underwent neuroimaging at 3 timepoints, over 6 years. 78 participants with at least one scan were included in the final sample; 33 who met criteria for a definite PE at least once across all the timepoints (PE group), and 45 controls. Data from bilateral subfields of interest (CA1, CA2/3, CA4/DG, presubiculum and subiculum) were extracted for Linear Mixed Effects analyses. Before correction, subfield volumes were found to increase in the control group and decrease in the PE group for the right CA2 and CA2/3 subfields, with moderate to large effect sizes (d = −0.61, andd = −0.79, respectively). Before correction, right subiculum and left presubiculum volumes were reduced in the PE group compared to controls, regardless of time, with moderate effect sizes (d = −0.52, andd = −0.59, respectively). However, none of these effects survived correction. Severity of symptoms were not associated with any of the noted subfields. These findings provide novel insight to the discussion of the role of hippocampal subfield abnormalities in the pathophysiology underlying psychotic experiences.
An 8-model ensemble of CMIP6-derived ocean surface wave climate
Authors: Meucci Alberto , Young Ian R. , Trenham Claire , Hemer Mark 
Published: January 2024

AbstractWe present a global wind wave climate model ensemble composed of eight spectral wave model simulations forced by 3-hourly surface wind speed and daily sea ice concentration from eight different CMIP6 GCMs. The spectral wave model uses ST6 physics parametrizations and a global three-grid structure for efficient Arctic and Antarctic wave modeling. The ensemble performance is evaluated against a reference global multi-mission satellite altimeter database and the recent ECMWF IFS Cy46r1 ERA5 wave hindcast, ERA5H. For each ensemble member three 30-year slices, one historical, and two future emission scenarios (SSP1-2.6 and SSP5-8.5) are available, and cover two distinct periods: 1985–2014 and 2071–2100. Two models extend to 140 years (1961–2100) of continuous wind wave climate simulations. The present ensemble outperforms a previous CMIP5-forced wind wave climate ensemble, showing improved performance across all ocean regions. This dataset is a valuable resource for future wind wave climate research and can find practical applications in offshore and coastal engineering projects, providing crucial insights into the uncertainties connected to wind wave climate future projections.
Securing web applications against XSS and SQLi attacks using a novel deep learning approach
Authors: Tadhani Jaydeep R. , Vekariya Vipul , Sorathiya Vishal , Alshathri Samah , El-Shafai Walid 
Published: January 2024

AbstractModern web application development involves handling enormous amounts of sensitive and consequential data. Security is, therefore, a crucial component of developing web applications. A web application's security is concerned with safeguarding the data it processes. The web application framework must have safeguards to stop and find application vulnerabilities. Among all web application attacks, SQL injection and XSS attacks are common, which may lead to severe damage to Web application data or web functionalities. Currently, there are many solutions provided by various study for SQLi and XSS attack detection, but most of the work shown have used either SQL/XSS payload-based detection or HTTP request-based detection. Few solutions available can detect SQLi and XSS attacks, but these methods provide very high false positive rates, and the accuracy of these models can further be improved. We proposed a novel approach for securing web applications from both cross-site scripting attacks and SQL injection attacks using decoding and standardization of SQL and XSS payloads and HTTP requests and trained our model using hybrid deep learning networks in this paper. The proposed hybrid DL model combines the strengths of CNNs in extracting features from input data and LSTMs in capturing temporal dependencies in sequential data. The soundness of our approach lies in the use of deep learning techniques that can identify subtle patterns in the data that traditional machine learning-based methods might miss. We have created a testbed dataset of Normal and SQLi/XSS HTTP requests and evaluated the performance of our model on this dataset. We have also trained and evaluated the proposed model on the Benchmark dataset HTTP CSIC 2010 and another SQL/XSS payload dataset. The experimental findings show that our proposed approach effectively identifies these attacks with high accuracy and a low percentage of false positives. Additionally, our model performed better than traditional machine learning-based methods. This soundness approach can be applied to various network security applications such as intrusion detection systems and web application firewalls. Using our model, we achieved an accuracy of 99.84%, 99.23% and 99.77% on the SQL-XSS Payload dataset, Testbed dataset and HTTP CSIC 2010 dataset, respectively.
Inhibitory role of copper and silver nanocomposite on important bacterial and fungal pathogens in rice (Oryza sativa)
Authors: Chowdhury Arnab Roy , Kumar Rishikesh , Mahanty Arabinda , Mukherjee Koel , Kumar Sudhir , Tribhuvan Kishor U. , Sheel Rishav , Lenka Srikanta , Singh Binay K. , Chattopadhyay Chirantan , Sharma T. R. , Bhadana Vijai Pal , Sarkar Biplab 
Published: January 2024

AbstractRice (Oryza sativa) being among the most important food crops in the world is also susceptible to various bacterial and fungal diseases that are the major stumbling blocks in the way of increased production and productivity. The bacterial leaf blight caused by Xanthomonas oryzae pv. oryzae and the sheath blight disease caused by Rhizoctonia solani are among the most devastating diseases of the rice crop. In spite of the availability of array of chemical control, there are chances of development of resistance. Thus, there is a need for the nanotechnological intervention for management of disease in the form of copper and silver nano-composites. The copper (CuNPs) and silver nanoparticles (AgNPs) were synthesized using green route and characterized using different high throughput techniques, i.e., UV–Vis, FT-IR, DLS, XRD, FE-SEM, TEM. The particle size and zeta potential of synthesized CuNPs and AgNPs were found 273 nm and − 24.2 mV; 95.19 nm and − 25.5 mV respectively. The nanocomposite of CuNPs and AgNPs were prepared having particle size in the range of 375–306 nm with improved stability (zeta potential − 54.7 to − 39.4 mV). The copper and silver nanoparticle composites evaluated against Xanthomonas oryzae pv. oryzae and Rhizoctonia solani were found to have higher antibacterial (inhibition zone 13 mm) and antifungal activities (77%) compared to only the copper nanoparticle (8 mm; 62% respectively). Net house trials of nano-composite formulations against the bacterial blight of rice also corroborated the potential of nanocomposite formulation. In silico studies were carried out selecting two disease-causing proteins, peptide deformylase (Xanthomonas oryzae) and pectate lyase (Rhizoctonia solani) to perform the molecular docking. Interaction studies indicatedthat both of these proteins generated better complex with CuNPs than AgNPs. The study suggested that the copper and silver nano-composites could be used for developing formulations to control these devastating rice diseases.
Crystallization from solution versus mechanochemistry to obtain double-drug multicomponent crystals of ethacridine with salicylic/acetylsalicylic acids
Authors: Mirocki Artur , Lopresti Mattia , Palin Luca , Conterosito Eleonora , Sikorska Emilia , Sikorski Artur , Milanesio Marco 
Published: January 2024

AbstractSalicylic and acetylsalicylic acids and ethacridine have complementary bioactive properties. They can be combined to obtain double-drug multicomponent crystals. Their reactivity in different environments was explored to obtain the possible compounds, stable at different hydration degrees. Solution, liquid-assisted grinding, and dry preparation approaches were applied to the couples of reactants in different stoichiometric ratios. Four compounds were obtained, and three out of them were stable and reproducible enough to determine their structures using SCXRD or PXRD methods. When coupled to ethacridine, salicylic acid gave two stable structures (1 and 3, both showing 1:1 ratio but different hydration degree) and a metastable one (5), while acetylsalicylic acid only one structure from solution (2 in 1:1 ratio), while LAG caused hydrolysis and formation of the same compound obtained by LAG of ethacridine with salicylic acid. While solution precipitation gave dihydrated (1) or monohydrated (2) structures with low yields, LAG of salicylic acid and ethacridine allowed obtaining an anhydrous salt complex (3) with a yield close to 1. The structures obtained by solution crystallizations maximize π(acridine)–π(acridine) contacts with a less compact packing, while the LAG structure is more compact with a packing driven by hydrogen bonds. For all compounds, NMR, ATR-FTIR, and Hirshfeld surface analysis and energy framework calculations were performed.
Energy-use efficiency of organic and conventional plant production systems in Germany
Authors: Chmelíková Lucie , Schmid Harald , Anke Sandra , Hülsbergen Kurt-Jürgen 
Published: January 2024

AbstractSustainable and efficient energy use in agriculture helps tackle climate change by reducing fossil energy use. We evaluated German farming systems by analysing energy input and output. Data from 30 organic and 30 conventional farms (12 arable, 18 dairy farms each) between 2009 and 2011 was used. Energy input, output, and the influence of farm type, farm structure, and management intensity on energy-use efficiency (EUE) were analysed for crop production using the farm management system REPRO. Conventional farms (CF) always had higher energy input. The energy input for organic farms (OF) was 7.2 GJ ha−1 and for CF 14.0 GJ ha−1. The energy output of CF was also higher. Reductions were higher in energy input than in energy output. In 73.3% of the farm pairs, OF were more energy efficient than CF. The EUE was comparable with CF on 10% of OF and for 16.7% of CF the EUE was higher suggesting better fossil energy utilization. EUE can be increased when reducing fossil energy inputs through more efficient machinery, reduction of agrochemicals, precision farming, the use of renewable energy or energy retention, and by increasing yields. A reduction of inputs is urgently required to lower the (political) dependence on fossil energy.
The superior colliculus motor region does not respond to finger tapping movements in humans
Authors: Prabhu Nikhil G. , Knodel Nicole , Himmelbach Marc 
Published: January 2024

AbstractElectrophysiological studies in macaques and functional neuroimaging in humans revealed a motor region in the superior colliculus (SC) for upper limb reaching movements. Connectivity studies in macaques reported direct connections between this SC motor region and cortical premotor arm, hand, and finger regions. These findings motivated us to investigate if the human SC is also involved in sequential finger tapping movements. We analyzed fMRI task data of 130 subjects executing finger tapping from the Human Connectome Project. While we found strong signals in the SC for visual cues, we found no signals related to simple finger tapping. In subsequent experimental measurements, we searched for responses in the SC corresponding to complex above simple finger tapping sequences. We observed expected signal increases in cortical motor and premotor regions for complex compared to simple finger tapping, but no signal increases in the motor region of the SC. Despite evidence for direct anatomical connections of the SC motor region and cortical premotor hand and finger areas in macaques, our results suggest that the SC is not involved in simple or complex finger tapping in humans.