bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial exploration of rural capital contributing to quality of life and urban-to-rural migration decisions: a case study of Hokuto City, Japan
Authors: Takahashi Yasuo , Yoshida Takahiro , Shigeto Sawako , Kubota Hiroyuki , Johnson Brian Alan , Yamagata Yoshiki 
Published: January 2024

AbstractGlobally, urbanization constitutes one of the major underlying drivers of global ecological degradation. Hence, deurbanization, i.e., demographic shift from urban to distant rural areas in a way that increases quality of life (QoL), can be one of the key pathways to address this global challenge. In this study, we investigated the contribution of nature and other types of rural capital to QoL and to people’s decision to migrate from urban to rural areas by studying residents in Hokuto City, a popular urban-to-rural migration destination in Japan. An integrated analysis of the 414 responses to a questionnaire survey and open and commercial geospatial datasets representing natural, built, human, cultural, and financial capital revealed the contributions of specific elements of rural capital to people’s QoL. These included natural capital (farmland, symbolic natural sites, mountain peak view, lower temperature, and tranquility), built capital (highways, railway stations, shops, and restaurants), and financial capital (employment). Many of these are related to the reasons that migrants, including return and one-way migrants, chose their present home location in Hokuto City, indicating their intention to increase QoL by migration. Particularly, one-way migrant homes were located predominantly on higher up mountain slopes with lower temperatures, higher forest cover, near natural parks, and symbolic natural sites, and yet with easier access to railway stations and employment. These results provide a valuable evidence base for rural spatial planning for increased QoL and attracting migrants that considers ecological–social feedbacks, and hence supports deurbanization.
Efficacy and Safety of Ketamine-Dexmedetomidine Versus Ketamine-Propofol Combination for Periprocedural Sedation: A Systematic Review and Meta-analysis
Authors: Elsaeidy Ahmed Saad , Ahmad Aya Hisham Moussa , Kohaf Neveen A. , Aboutaleb Aya , Kumar Danisha , Elsaeidy Khaled Saad , Mohamed Ola saeed , Kaye Alan D. , Shehata Islam Mohammad 
Published: January 2024

Abstract
Purpose of Review
The combination of ketamine with propofol and dexmedetomidine has gained popularity for sedation and general anesthesia in different populations. In our meta-nalysis, we helped the anesthesiologists to know the efficiency and the efficacy of both combinations in adult and pediatric patients.

Methods
We searched PubMed, CENTRAL, Web of Science, and Scopus from inception to August 1, 2023. Our outcome parameters for efficacy were recovery time, pain score, and physician satisfaction while for safety were the related cardiorespiratory, neurological, and gastrointestinal adverse events.

Recent Findings
Twenty-two trials were included with a total of 1429 patients. We found a significantly longer recovery time in the ketadex group of 7.59 min (95% CI, 4.92, 10.26; I2 = 94%) and a significantly less pain score of − 0.72 (95% CI, − 1.10, − 0.34; I2 = 0%). Adults had a significantly better physician satisfaction score with the ketofol group, odds ratio of 0.29 (95% CI, 0.12, 0.71; I2 = 0%). Recovery agitations were higher in the ketofol group with an odds ratio of 0.48 (95% CI, 0.24, 0.98; I2 = 36%). Furthermore, we found a significant difference between the combinations with a higher incidence in the ketadex group with pooled odds ratio of 1.75 (95% CI, 1.06, 2.88; I2 = 15%).

Summary
Ketadex was associated with lower pain scores, hypoxic events and airway obstruction, and emergence agitation. At the same time, ketofol had much more clinician satisfaction which might be attributed to the shorter recovery time and lower incidence of nausea and vomiting. Therefore, we suppose that ketadex is the better combination in periprocedural sedation for both adult and pediatric patients who are not at greater risk for postoperative nausea and vomiting.
Clinical and outcome comparison of genetically positive vs. negative patients in a large cohort of suspected familial hypocalciuric hypercalcemia
Authors: Asla Queralt , Sardà Helena , Seguí Núria , Martínez de Pinillos Guillermo , Mazarico-Altisent Isabel , Capel Ismael , Rives José , Suárez Javier , Ávila-Rubio Verónica , Muñoz Torres Manuel , Saigí Ignasi , Palacios Nuria , Urgell Eulàlia , Webb Susan M. , Fernández Mercè , Oriola Josep , Mora Mireia , Tondo Mireia , Aulinas Anna 
Published: January 2024

Abstract
Objective
Biochemical suspicion of familial hypocalciuric hypercalcemia (FHH) might provide with a negative (FHH-negative) or positive (FHH-positive) genetic result. Understanding the differences between both groups may refine the identification of those with a positive genetic evaluation, aid management decisions and prospective surveillance. We aimed to compare FHH-positive and FHH-negative patients, and to identify predictive variables for FHH-positive cases.

Design
Retrospective, national multi-centre study of patients with suspected FHH and genetic testing of the CASR, AP2S1 and GNA11 genes.

Methods
Clinical, biochemical, radiological and treatment data were collected. We established a prediction model for the identification of FHH-positive cases by logistic regression analysis and area under the ROC curve (AUROC) was estimated.

Results
We included 66 index cases, of which 30 (45.5%) had a pathogenic variant. FHH-positive cases were younger (p = 0.029), reported more frequently a positive family history (p < 0.001), presented higher magnesium (p < 0.001) and lower parathormone levels (p < 0.001) and were less often treated for hypercalcemia (p = 0.017) in comparison to FHH-negative cases. Magnesium levels showed the highest AUROC (0.825, 95%CI: 0.709–0.941). The multivariate analysis revealed that family history and magnesium levels were independent predictors of a positive genetic result. The predictive model showed an AUROC of 0.909 (95%CI: 0.826–0.991).

Conclusions
The combination of magnesium and a positive family history offered a good diagnostic accuracy to predict a positive genetic result. Therefore, the inclusion of magnesium measurement in the routine evaluation of patients with suspected FHH might provide insight into the identification of a positive genetic result of any of the CaSR-related genes.
Patient-Related Outcome Measures for Oculomotor Symptoms in the Cerebellar Ataxias: Insights from Non-Cerebellar Disorders
Authors: Szmulewicz David J. , Galli Rocco , Tarnutzer Alexander A. 
Published: January 2024

AbstractIn patients with cerebellar ataxia (CA), symptoms related to oculomotor dysfunction significantly affect quality of life (QoL). This study aimed to analyze the literature on patient-related outcome measures (PROMs) assessing QoL impacts of vestibular and cerebellar oculomotor abnormalities in patients with CA to identify the strengths and limitations of existing scales and highlight any areas of unmet need. A systematic review was conducted (Medline, Embase) of English-language original articles reporting on QoL measures in patients with vertigo, dizziness or CA. Pre-specified parameters were retrieved, including diseases studied, scales applied and conclusions drawn. Our search yielded 3671 articles of which 467 studies (n = 111,606 participants) were deemed relevant. The most frequently studied disease entities were (a) non-specific dizziness/gait imbalance (114 studies; 54,581 participants), (b) vestibular schwannomas (66; 15,360), and (c) vestibular disorders not further specified (66; 10,259). The Dizziness Handicap Inventory (DHI) was the most frequently used PROM to assess QoL (n = 91,851), followed by the Penn Acoustic Neuroma Quality-of-Life Scale (n = 12,027) and the Activities-Specific Balance Confidence Scale (n = 2’471). QoL-scores capturing symptoms related to oculomotor abnormalities in CA were rare, focused on visual impairments (e.g., National-Eye-Institute Visual Function Questionnaire, Oscillopsia Functional Impact, oscillopsia severity score) and were unvalidated. The DHI remains the most widely used and versatile scale for evaluating dizziness. A lack of well-established PROMs for assessing the impact of oculomotor-related symptoms on QoL in CA was noted, emphasizing the need for developing and validating a new QoL-score dedicated to the oculomotor domain for individuals with CA.
Changes in healthcare utilisation during implementation of remote atrial fibrillation management: TeleCheck-AF project
Authors: Gawałko Monika , Betz Konstanze , Hendriks Veerle , Hermans Astrid N. L. , van der Velden Rachel M. J. , Manninger Martin , Chaldoupi Sevasti-Maria , Hoogervorst Henk , Martens Herm , Pluymaekers Nikki A. H. A. , Spreeuwenberg Marieke D. , Hendriks Jeroen , Linz Dominik 
Published: January 2024

Abstract
Aim
To evaluate changes in healthcare utilisation and comprehensive packages of care activities and procedures (referred in the Netherlands to as ‘diagnose-behandelcombinatie (DBC) care products) during the implementation of the TeleCheck-AF approach (teleconsultation supported by app-based heart rate/rhythm monitoring) in a Dutch atrial fibrillation (AF) clinic.

Methods and results
In the Maastricht University Medical Centre+ AF Clinic, data on healthcare utilisation and DBC care products for patients consulted by both a conventional approach in 2019 and the TeleCheck-AF approach in 2020 were analysed. A patient experience survey was performed. Thirty-seven patients (median age 68 years; 40% women) were analysed. With the conventional approach, 35 face-to-face consultations and 0 teleconsultations were conducted. After the implementation of TeleCheck-AF, the number of face-to-face consultations dropped by 80% (p < 0.001) and teleconsultations increased to 45 (p < 0.001). While 42 electrocardiograms (ECGs) and 25 Holter ECGs or echocardiograms were recorded when using the conventional approach, the number of ECGs decreased by 71% (p < 0.001) and Holter ECGs or echocardiograms by 72% (p < 0.001) with the TeleCheck-AF approach. The emergency department patient presentations showed no statistically significant change (p = 0.33). Overall, 57% of medium-weight DBC care products were changed to light-weight ones during implementation of the TeleCheck-AF approach. Patient satisfaction with the TeleCheck-AF approach was high.

Conclusion
The implementation of TeleCheck-AF led to a change in healthcare utilisation, a change from medium-weight to light-weight DBC care products and a reduction in patient burden. These results created the basis for a new reimbursement code for the TeleCheck-AF approach in the Netherlands.
GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis
Authors: Zhao Qianwei , Yu Mengdan , Li Jinxia , Guo Yaoyu , Wang Zexuan , Hu Kefei , Xu Fang , Liu Yixian , Li Lili , Wan Didi , Zhao Ying , Shang Jian , Zhang Jintao 
Published: January 2024

AbstractGlutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated in tumor tissues of hepatocellular carcinoma (HCC) patients by proteomics study. To explore its role in the progression of HCC, the expressional level of GLUD1 was firstly examined and presented as that both the protein and mRNA levels were down-regulated in tumor tissues compared to the normal liver tissues. GLUD1 overexpression significantly inhibited HCC cells proliferation, migration, invasion and tumor growth both in vitro and in vivo, while GLUD1 knocking-down promoted HCC progression. Metabolomics study of GLUD1 overexpressing and control HCC cells showed that 129 differentially expressed metabolites were identified, which mainly included amino acids, bases, and phospholipids. Moreover, metabolites in mitochondrial oxidative phosphorylation system (OXPHOS) were differentially expressed in GLUD1 overexpressing cells. Mechanistic studies showed that GLUD1 overexpression enhanced mitochondrial respiration activity and reactive oxygen species (ROS) production. Excessive ROS lead to mitochondrial apoptosis that was characterized by increased expression levels of p53, Cytochrome C, Bax, Caspase 3 and decreased expression level of Bcl-2. Furthermore, we found that the p38/JNK MAPK pathway was activated in GLUD1 overexpressing cells. N-acetylcysteine (NAC) treatment eliminated cellular ROS and blocked p38/JNK MAPK pathway activation, as well as cell apoptosis induced by GLUD1 overexpression. Taken together, our findings suggest that GLUD1 inhibits HCC progression through regulating cellular metabolism and oxidative stress state, and provide that ROS generation and p38/JNK MAPK pathway activation as promising methods for HCC treatment.
Schulbücher und digitale Lernplattformen: Eine vergleichende Analyse von Aufgaben hinsichtlich kognitiver Aktivierung und Visualisierungen
Authors: Thurm Daniel , Barzel Bärbel , Büchter Andreas 
Published: January 2024

Zusammenfassung
Im Zuge der fortschreitenden Digitalisierung halten Lernplattformen verstärkt Einzug in den Schulalltag und stellen – auch dem eigenen Anspruch nach – eine Alternative zu Schulbüchern dar. Die vorliegende Studie untersucht das Potenzial zur kognitiven Aktivierung sowie die Art der einbezogenen Visualisierungen von Übungsaufgaben aus Schulbüchern und von digitalen Lernplattformen für den Mathematikunterricht in der Sekundarstufe I. Hierzu wurden insgesamt 811 Aufgaben aus drei Schulbüchern und 224 Aufgaben von drei Lernplattformen aus den Inhaltsbereichen „Multiplikation von Brüchen“ und „Satz des Pythagoras“ mit Hilfe eines differenzierten Kategoriensystems untersucht. Es zeigt sich, dass Übungsaufgaben in Schulbüchern als auch Lernplattformen ein überwiegend geringes Potenzial zur kognitiven Aktivierung bieten, wobei Schulbücher tendenziell ein höheres Potenzial zur kognitiven Aktivierung realisieren. Insbesondere fehlen bei Lernplattformen oftmals Aufgaben mit hohem Potenzial zur kognitiven Aktivierung. Hinsichtlich der Visualisierungen zeigt sich, dass sowohl Schulbücher als auch Lernplattformen vor allem vollständig mathematisierte Visualisierungen bei Aufgaben nutzen. Dadurch reduzieren sich für Lernende die Gelegenheiten, selbst Visualisierungen zu erstellen. Weiterhin zeigt sich überraschenderweise, dass Lernplattformen potenziell lernförderliche, multiple, dynamische und interaktiv-vernetzte Repräsentationen trotz der technischen Möglichkeiten fast überhaupt nicht nutzen. Basierend auf den Ergebnissen der Studie werden Konsequenzen für Forschung und Entwicklung diskutiert.
Auditive Emotion Recognition for Empathic AI-Assistants
Authors: Duwenbeck Roswitha , Kirchner Elsa Andrea 
Published: January 2024

AbstractThis paper briefly introduces the Project “AudEeKA”, whose aim is to use speech and other bio signals for emotion recognition to improve remote, but also direct, healthcare. This article takes a look at use cases, goals and challenges, of researching and implementing a possible solution. To gain additional insights, the main-goal of the project is divided into multiple sub-goals, namely speech emotion recognition, stress detection and classification and emotion detection from physiological signals. Also, similar projects are considered and project-specific requirements stemming from use-cases introduced. Possible pitfalls and difficulties are outlined, which are mostly associated with datasets. They also emerge out of the requirements, their accompanying restrictions and first analyses in the area of speech emotion recognition, which are shortly presented and discussed. At the same time, first approaches to solutions for every sub-goal, which include the use of continual learning, and finally a draft of the planned architecture for the envisioned system, is presented. This draft presents a possible solution for combining all sub-goals, while reaching the main goal of a multimodal emotion recognition system.
Digital Distraction, Attention Regulation, and Inequality
Authors: Kärki Kaisa 
Published: January 2024

AbstractIn the popular and academic literature on the problems of the so-called attention economy, the cost of attention grabbing, sustaining, and immersing digital medias has been addressed as if it touched all people equally. In this paper I ask whether everyone has the same resources to respond to the recent changes in their stimulus environments caused by the attention economy. I argue that there are not only differences but disparities between people in their responses to the recent, significant increase in the degree and persuasiveness of digital distraction. I point toward individual variance in an agent’s top-down and bottom-up attention regulation, and to further inequality-exacerbating variance in active participation on the internet and in regulating reward-seeking behaviors on the internet. Individual differences in these areas amount to disparities because they have been found to be connected to socioeconomic background factors. I argue that disparities in responding to digital distraction threaten fair equality of opportunity when it comes to digital distraction in the classroom and that they may lead to an unequal contribution of achievements that require complex cognition by people from lower socioeconomic backgrounds.
Origin and evolution of false brinelling and fretting corrosion under rolling conditions
Authors: Jia Xin , Huang Lu , Sun Miao , Li Wenbin 
Published: January 2024

AbstractRolling bearings working in oscillating applications often suffer from false brinelling and fretting corrosion that limit their service life. At present, the study of oscillation-induced failures is primarily dominated by a large number of sliding and bench tests. However, most of the previous work are not able to fully describe the two closely related but different failure mechanisms. In this study, the origin and evolution of the two failures are thoroughly investigated under strictly controlled oscillating rolling conditions. The results show that failure evolves from false brinelling to fretting corrosion under dry friction conditions regardless of the oscillation amplitude. This process is accompanied by a large area peeling and serious oxidation, and the oxygen content increases from 2.50 wt% to 21.22 wt%. Oxidation is a crucial factor in the evolution of false brinelling into fretting corrosion. However, the distribution of microwear and oxygen content depend on the oscillation amplitude. Under lubrication conditions, the friction coefficient (COF) is smaller in the initial stage and led to local slip or transient instability of rolling elements. Therefore, the size of the wear marks and COF increased and appeared to be larger than those under a dry friction condition. However, grease can separate the contact surfaces, only surface deformation owing to false brinelling and slight damage at the roughness level occurred. The evolution of false brinelling and fretting corrosion is also closely related to residual stress. False brinelling often occurrs with residual stress accomulation, meanwhile, the residual stress increases from 120 to 300 MPa. When peeling occurs, residual stress is released. The failure pattern transformed from false brinelling to fretting corrosion and is accompanied by oxidation. So far, none of investigation is able to show satisfactory evolution of oscillating-induced failures, this study may contribute to more scientific understanding of rolling bearings against long-run reciprocating oscillating wear.
A new method to solve the Reynolds equation including mass-conserving cavitation by physics informed neural networks (PINNs) with both soft and hard constraints
Authors: Xi Yinhu , Deng Jinhui , Li Yiling 
Published: January 2024

AbstractIn this work, a new method to solve the Reynolds equation including mass-conserving cavitation by using the physics informed neural networks (PINNs) is proposed. The complementarity relationship between the pressure and the void fraction is used. There are several difficulties in problem solving, and the solutions are provided. Firstly, the difficulty for considering the pressure inequality constraint by PINNs is solved by transferring it into one equality constraint without introducing error. While the void fraction inequality constraint is considered by using the hard constraint with the max-min function. Secondly, to avoid the fluctuation of the boundary value problems, the hard constraint method is also utilized to apply the boundary pressure values and the corresponding functions are provided. Lastly, for avoiding the trivial solution the limitation for the mean value of the void fraction is applied. The results are validated against existing data, and both the incompressible and compressible lubricant are considered. Good agreement can be found for both the domain and domain boundaries.
Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy
Authors: Arosio M. , Sciannameo V. , Contarino A. , Berchialla P. , Puglisi S. , Pesatori A. C. , Ferrante E. , Filopanti M. , Pivonello R. , Dassie F. , Rochira V. , Cannavò S. , De Menis E. , Pigliaru F. , Grottoli S. , Cambria V. , Faustini-Fustini M. , Montini M. , Peri A. , Ceccato F. , Puxeddu E. , Borretta G. , Bondanelli M. , Ferone D. , Colao A. , Terzolo M. , Reimondo G. 
Published: January 2024

Abstract
Objective
This study aimed to assess the long-term outcome of patients with acromegaly.

Design
This is a multicenter, retrospective, observational study which extends the mean observation period of a previously reported cohort of Italian patients with acromegaly to 15 years of follow-up.

Methods
Only patients from the centers that provided information on the life status of at least 95% of their original cohorts were included. Life status information was collected either from clinical records or from the municipal registry offices. Standardized mortality ratios (SMRs) were computed comparing data with those of the general Italian population.

Results
A total of 811 patients were included. There were 153 deaths, with 90 expected and an SMR of 1.7 (95% CI 1.4–2.0, p < 0.001). Death occurred after a median of 15 (women) or 16 (men) years from the diagnosis, without gender differences. Mortality remained elevated in the patients with control of disease (SMR 1.3, 95% CI 1.1–1.6). In the multivariable analysis, only older age and high IGF1 concentrations at last available follow-up visit were predictors of mortality. The oncological causes of death outweighed the cardiovascular ones, bordering on statistical significance with respect to the general population.

Conclusions
Mortality remains significantly high in patients with acromegaly, irrespectively of disease status, as long as the follow-up is sufficiently long with a low rate of patients lost to follow-up. Therapy strategy including radiotherapy does not have an impact on mortality. Oncological causes of death currently outweigh the cardiovascular causes.