bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfluoroalkylation of 2‐Mercaptoethanol as a Key Step for a New Synthesis of Perfluoroalkyl Vinyl Sulfides, Sulfoxides and Sulfones.
Authors: Magnier Emmanuel , Tordeux Marc , Goumont Regis , Magder Karine , Wakselman Claude 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Asymmetric Reduction of Acetophenone and Propiophenone by NaAl(IPTOLate)H2 Combined with Enantiomeric Enrichment of the Reaction Product as an Inclusion Complex with IPTOL.
Authors: Vinogradov M. G. , Gorshkova L. S. , Chel'tsova G. V. , Kurilov D. V. , Ferapontov V. A. , Shishkin O. V. , Heise G. L. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction and Characterization of Thioamide Dianions Derived from N‐Benzyl Thioamides.
Authors: Murai Toshiaki , Aso Hideo , Tatematsu Yoshiharu , Itoh Yoshiaki , Niwa Hisayuki , Kato Shinzi 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Room‐Temperature Palladium‐Catalyzed Cyanation of Aryl Bromides and Iodides with Tri‐t‐butylphosphine as Ligand.
Authors: Ramnauth Jailall , Bhardwaj Namrta , Renton Paul , Rakhit Suman , Maddaford Shawn P. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
(E)‐Selective Horner—Wadsworth—Emmons Reaction of Aryl Alkyl Ketones with Bis(2,2,2‐trifluoroethyl)phosphonacetic Acid.
Authors: Sano Shigeki , Takemoto Yuka , Nagao Yoshimitsu 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antimicrobial Activity of Some New 1‐Cyclohexyl‐3‐carbethoxy‐2‐methyl‐5‐oxadiazolyl/triazolyl and Pyrrolylaminocarbonylmethoxyindoles.
Authors: Gadaginamath Guru S. , Pujar Shashikant R. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Evaluation of Some New 1,3‐Disubstituted 2‐Thioxo‐4,5‐Imidazolidinediones as Hypnotic Agents.
Authors: Ulusoy N. , Guersu E. , Oezkirimli S. , Ekinci A. C. , Dikici I. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Improved Synthesis of N‐Arylsulfonyl‐2‐imidazolidinones Through Reaction of N‐Arylsulfonylaziridines with Isocyanates Catalyzed by Lithium Iodide.
Authors: Nadir Upender K. , Joshi Susan 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Comparative Study on the Reactivity of 6‐Haloimidazo[1,2‐a]pyridine Derivatives Towards Negishi‐ and Stille‐Coupling Reactions.
Authors: Hervet Maud , Thery Isabelle , Gueiffier Alain , Enguehard‐Gueiffier Cecile 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Synthesis of S 18986, a Chiral AMPA Receptor Modulator, via Catalytic Asymmetric Hydrogenation.
Authors: Cobley Christopher J. , Foucher Elsa , Lecouve Jean‐Pierre , Lennon Ian C. , Ramsden James A. , Thominot Gilles 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
2,5‐Disubstituted 3,4‐Dihydro‐2H‐benzo[b][1,4]thiazepines as Potent and Selective V2 Arginine Vasopressin Receptor Antagonists.
Authors: Urbanski Maud J. , Chen Robert H. , Demarest Keith T. , Gunnet Joseph , Look Richard , Ericson Eric , Murray William V. , Rybczynski Philip J. , Zhang Xiaoyan 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Lipids from the Soft Corals of the Andaman Islands.
Authors: Dmitrenok A. S. , Radhika P. , Anjaneyulu V. , Subrahmanyam S. , Rao P. V. Subba , Dmitrenok P. S. , Boguslavsky V. M. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Artoindonesianins X and Y, Two Isoprenylated 2‐Arylbenzofurans, from Artocarpus fretessi (Moraceae).
Authors: Soekamto Nunuk H. , Achmad Sjamsul A. , Ghisalberti Emilio L. , Hakim Euis H. , Syah Yana M. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
7‐Methoxy‐2,3‐dimethylbenzofuran‐5‐ol, a New Antioxidant from Malbranchea cinnamomea HKI 0286.
Authors: Schlegel B. , Haertl A. , Gollmick F. A. , Graefe U. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalysis of Nucleophilic Aromatic Substitutions in the 2,6,8‐Trisubstituted Purines and Application in the Synthesis of Combinatorial Libraries
Authors: Riva‐Toniolo Claudia , Mueller Sascha , Schaub Josette , Brill Wolfgang K.‐D. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Glucansucrases: Structural Basis, Mechanistic Aspects, and New Perspectives for Engineering
Authors: Remaud‐Simeon Magali , Albenne Cecile , Joucia Gilles , Fabre Emeline , Bozonnet Sophie , Pizzut Sandra , Escalier Pierre , Potocki‐Veronese Gabrielle , Monsan Pierre 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
1‐Thio‐1,2‐O‐isopropylidene Acetals: Annulating Synthons for Highly Hydroxylated Systems
Authors: Mootoo David R. , Cheng Xuhong , Khan Noshena , Dabideen Darrin , Kumaran Govindaraj , Bao Liang 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Magnetism and 155Gd Moessbauer Spectroscopy of GdAuMg.
Authors: Latka Kazimierz , Kmiec Roman , Pacyna Andrzej W. , Fickenscher Thomas , Hoffmann Rolf‐Dieter , Poettgen Rainer 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Structural Characterization, and Thermal Stability of a New Layered Germanate Structure, Na4Ge16O28(OH)12.
Authors: van den Berg Annemieke W. C. , Baak Govert , van Koningsveld Hendrikus , Jansen Jacobus C. , Maschmeyer Thomas 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cs2Pd3(P2O7)2 and Cs2Pd3(As2O7)2: A 3D Palladium Phosphate with a Tunnel Structure and a 2D Palladium Arsenate Containing Strings of Palladium Atoms.
Authors: Lii Kwang‐Hwa , Wang Sue‐Lein , Liao Fen‐Ling 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Studies on 1‐O‐Acetylbritannilactone and Its Derivative, (2‐O‐Butyloxime‐3‐phenyl)‐propionyl‐1‐O‐acetylbritannilactone Ester
Authors: Liu Shouxin , Liu He , Yan Weiying , Zhang Li , Bai Naisheng , Ho Chi‐Tang 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS
Authors: Yang Peng , Baker K. Adam , Hagg Theo 
Published: July 2005

AbstractWe have reported that α6β1 integrin regulates the directed migration of neuroblasts from the adult rodent subventricular zone (SVZ) through the rostral migratory stream (RMS). ADAM (a disintegrin and metalloprotease) proteins bind integrins. Here, we show that ADAM21, but not ADAM2, ‐3, ‐9, ‐10, ‐12, ‐15, or ‐17, is expressed in adult rats and mice by ependyma and SVZ cells with long basal processes, and in radial glia at early postnatal times. ADAM21‐positive processes projected into the RMS, contacted blood vessels, and were present within the RMS intermingled with neuroblasts up to where neuroblasts start their radial migration and differentiation in the olfactory bulb. Tissue inhibitors of metalloproteases (TIMPs) 1, 2, and 3 are present in the ependymal layer but not in the SVZ and RMS. Thus, ADAM21 could regulate neurogenesis and guide neuroblast migration through cleavage‐dependent activation of proteins and integrin binding. ADAM21 is also present in growing axonal tracts during postnatal development and in growing primary olfactory axons in adults. In the olfactory nerve layer, ADAM21 often, but not always, colocalizes with OMP, a marker of mature olfactory neurons, but is not colocalized with the immature marker βIII‐tubulin. This suggests that ADAM21 is involved in the final axonal outgrowth phase and/or synapse formation. TIMP3 is present in periglomerular neurons, where it could restrict ADAM21‐mediated axonal growth to the glomeruli. ADAM21's unique disintegrin and metalloprotease sequences and its restricted expression suggest that it might be a good target for influencing neurogenesis and neuronal plasticity. J. Comp. Neurol. 490:163–179, 2005. © 2005 Wiley‐Liss, Inc.
Profile of differentially expressed genes after transfer of chromosome 17 into the breast cancer cell line CAl51
Authors: Klebig Christiane , Seitz Susanne , Korsching Eberhard , Kristiansen Glen , Gustavus Dirk , Scherneck Siegfried , Petersen Iver 
Published: July 2005

AbstractPrevious studies have shown that transfer of chromosome 17 suppresses the tumorigenic phenotype of the breast cancer cell line CAL51, suggesting the presence of putative tumor suppressor genes on this chromosome. Suppression subtractive hybridization and oligonucleotide microarray analyses were performed to identify differentially expressed genes in nontumorigenic microcell hybrids, CAL/17‐1 and CAL/17‐3, when compared with CAL51 cells. In total, 263 differentially expressed transcripts were associated with these phenotypes. Of these, a high percentage is involved in various biological processes associated with tumorigenesis, including DNA‐dependent regulation of transcription, regulation of cell cycle, signal transduction, and cell proliferation. Microarray analysis of selected chromosome 17 genes in a series of 25 human primary breast tumors showed associations with clinicopathologic parameters of the tumors. Of these genes, TOB1 (transducer of ERBB2) was selected for further expression analysis. Using RT‐PCR and immunohistochemical staining of tissue microarrays, we could reveal a differential mRNA and protein expression of TOB1 in the majority of breast tumors and lymph node metastases compared with normal breast tissues, indicating a potential role of this protein in breast tumorigenesis. © 2005 Wiley‐Liss, Inc.
Involvement of P‐glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug‐resistant osteosarcoma and Ewing's sarcoma cells
Authors: Okada Takamitsu , Tanaka Kazuhiro , Nakatani Fumihiko , Sakimura Riku , Matsunobu Tomoya , Li Xu , Hanada Masuo , Nakamura Tomoyuki , Oda Yoshinao , Tsuneyoshi Masazumi , Iwamoto Yukihide 
Published: July 2005

AbstractDespite recent improvements in multimodal therapies for osteosarcoma (OS) and Ewing's family of tumors (EFTs), the prognosis of relapsed cases remains very poor because of the resistance to chemotherapy. Histone deacetylase inhibitors (HDACIs), including members of the cyclic tetrapeptide family such as FK228 and apicidin, are novel antitumor agents that can induce cell cycle arrest and apoptosis in various cancer cells. HDACIs also exhibit potent antitumor effects on OS and EFTs. However, to date there have been no studies to our knowledge reporting the effects of HDACIs on drug‐resistant OS and EFTs. Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin‐resistant clones of OS and EFTs expressing P‐glycoprotein (P‐gp) and multidrug resistance‐associated protein 1 (MRP1) and that P‐gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. A P‐gp inhibitor (verapamil) and an MRP1 inhibitor (MK571) could independently reverse the resistance to FK228 and apicidin in the drug‐resistant clones. Moreover, the combination of verapamil and MK571 could enhance HDACI‐induced cell number reduction in drug‐resistant clones to a similar extent as that in their parental clones. Although these findings suggest the difficulty in treating drug‐resistant tumors expressing P‐gp and/or MRP1 with these HDACIs, the combination of P‐gp and MRP1 inhibitors might reverse the resistance to the HDACIs in the treatment of those tumors. Because HDACIs are potent and promising antitumor drugs and seem to be close to clinical use, it is necessary to pay attention to the resistance mechanisms against HDACIs. © 2005 Wiley‐Liss, Inc.
Elevation of thyroid cancer risk among cutaneous melanoma survivors
Authors: Goggins William , Daniels Gilbert H. , Tsao Hensin 
Published: July 2005

AbstractRecent molecular studies have identified recurrent BRAF mutations in both cutaneous melanoma and thyroid malignancies. This relatively selective shared genetic vulnerability raises the possibility that these 2 tumors are connected through a common undisclosed pathogenic mechanism. To assess for possible associations between these 2 genetically related tumors at the population level, we calculated standardized incidence ratios (SIRs) for thyroid cancer (TC) among cutaneous melanoma (CM) survivors and CM among TC survivors using the National Cancer Institute's Surveillance, Epidemiology and End Result (SEER) database. Between 1973 and 2000, there were 73,274 and 27,138 cases of CM and TC cases, respectively. Overall, we found a 2.17‐fold increase (p < 0.0000001) in the risk of TC after a diagnosis of CM. This augmented risk of TC is somewhat higher for males, for those diagnosed more recently and for the first 3 years after the CM diagnosis. We also detected a considerably smaller and borderline significant increased risk of CM (25%, p = 0.063) among the post‐TC survivors. Of note, TC patients who received radiation therapy had a 57% increased risk of a subsequent CM (p = 0.034). Our study documents a strong unilateral risk of TC after CM. More studies are clearly needed to better delineate this mechanism. © 2005 Wiley‐Liss, Inc.
Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow
Authors: Yamasaki Takuma , Deie Masataka , Shinomiya Rikuo , Izuta Yasunori , Yasunaga Yuji , Yanada Shinobu , Sharman Patrick , Ochi Mitsuo 
Published: July 2005

AbstractThe purpose of this study was to regenerate a meniscus using a scaffold from a normal meniscus and mesenchymal stromal cells derived from bone marrow (BM‐MSCs). Thirty Sprague‐Dawley rat menisci were excised and freeze‐thawed three times with liquid nitrogen to kill the original meniscal cells. Bone marrow was aspirated from enhanced green fluorescent protein transgenic Sprague‐Dawley rats. BM‐MSCs were isolated, cultured for 2 weeks, and 2 × 105 cells were then seeded onto the meniscal scaffolds. Using a fluorescent microscope and immunohistochemical staining, repopulation of enhanced green fluorescent protein positive cells was observed in the superficial zone of the scaffold after 1 week of culture, and then in the deep zone after 2 weeks. At 4 weeks, expression of extracellular matrices was detected histologically and expression of mRNA for aggrecan and type X collagen was detected. Stiffness of the cultured tissue, assessed by the indentation stiffness test, had increased significantly after 2 weeks in culture, and approximated the stiffness of a normal meniscus. From this study, we conclude that a scaffold derived from a normal meniscus seeded with BM‐MSCs can form a meniscus approximating a normal meniscus. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005
Co‐localization of PARP‐1 and lamin B in the nuclear architecture: A halo‐fluorescence‐ and confocal‐microscopy study
Authors: Vidaković Melita , Koester Mario , Goetze Sandra , Winkelmann Silke , Klar Martin , Poznanović Goran , Bode Juergen 
Published: July 2005

AbstractA functional interaction between poly(ADP‐ribose) polymerase‐1 (PARP‐1) and lamin B has recently been proposed by nuclear fractionation, crosslinking, and immunoprecipitation experiments. Here we use fluorescence microscopy to verify and extend these findings. We analyze nuclear halo preparations by fluorescence in situ immuno staining (FISIS), which shares attributes with traditional nuclear fractionation techniques, and by confocal laser scanning microscopy (CLSM). The results agree in that a major part of the enzyme co‐localizes with lamin B under physiological conditions, where PARP‐1 only has basal activity. After DNA damage and the associated activation of PARP‐1, and during the subsequent entry into apoptosis, dramatic changes occur: a gradual release of the enzyme from the lamina, accompanied by its accumulation in nucleoli. Our observations are in line with biochemical evidence for lamin B‐PARP‐1 interactions under physiological conditions and suggest ways by which these interactions are modified to support PARP‐functions in damage and its fate in apoptosis. © 2005 Wiley‐Liss, Inc.
Retinoic acid induced repression of AP‐1 activity is mediated by protein phosphatase 2A in ovarian carcinoma cells
Authors: Ramírez Carmilia Jiménez , Haberbusch Juliet M. , Soprano Dianne Robert , Soprano Kenneth J. 
Published: July 2005

AbstractIn previous studies we have shown that all‐trans retinoic acid (atRA)‐treatment of the atRA‐sensitive ovarian carcinoma cell line CA‐OV3 repressed AP‐1 activity by about 50%, while a similar effect was not observed in the atRA‐resistant ovarian carcinoma cell line, SK‐OV3. These results suggested that the repression of AP‐1 activity may be one of the mechanisms by which atRA inhibits the growth of atRA‐sensitive CA‐OV3 cells. In the present studies, we investigated further the molecular mechanism by which AP‐1 activity is repressed by atRA. We show that the repression of AP‐1 activity correlates with an increase in JunB protein expression and a decrease in N‐terminal phosphorylation of c‐Jun. The decrease in N‐terminal phosphorylation of c‐Jun does not appear to be modulated by JNK or ERK, since their protein expression patterns and kinase activity do not correlate with the repression of AP‐1 activity following treatment with atRA. However, the activity of the protein phosphatase PP2A was found to increase 24 h following atRA treatment in CA‐OV3 cells. Moreover, the catalytic subunit of PP2A was found to associate with c‐Jun in vivo following atRA treatment. Since the inhibition of AP‐1 activity following atRA treatment of CA‐OV3 cells was abolished in the presence of specific PP2A inhibitors, it is likely that PP2A plays an important role in the atRA‐induced repression of AP‐1. © 2005 Wiley‐Liss, Inc.
Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue
Authors: Srinivasan Lakshmi , Pan Xuan , Atchison Michael L. 
Published: July 2005

AbstractA hallmark of PcG transcriptional repression is stability of the repressed state, although the mechanism of this stability is unclear. The mammalian transcription factor YY1 can function as a PcG protein in Drosophila resulting in transcriptional repression and correction of phenotypic defects caused by mutation of its homologue, Pleiohomeotic (PHO). To discern the temporal requirements of YY1 expression for these functions, and to study its mechanism of stable repression in vivo, we used a Drosophila larval wing imaginal disc transcriptional repression system. We found that YY1 was needed transiently at day 3 or later of embryonic development to stably repress a reporter transgene at day 8 in wing imaginal discs. Stable transcriptional repression did not correlate with maintenance of YY1 or Polycomb DNA binding, but did correlate with persistence of histone H3 methylation on lysine 27. We also found that YY1 expressed during the first 7 days of development was sufficient for rescue of fly development (a 14 day process) in pho mutant flies. Therefore, YY1 was transiently required for correction of fly defects and was dispensable past the pharate adult stage. Possible mechanisms of repression by YY1 are discussed. © 2005 Wiley‐Liss, Inc.
Butterfat fatty acids differentially regulate growth and differentiation in Jurkat T‐cells
Authors: Bergamo Paolo , Luongo Diomira , Maurano Francesco , Rossi Mauro 
Published: July 2005

AbstractSynthetic Conjugated Linoleic Acid mixture (CLA; c9,t11; t10,c12‐18:2) has been previously shown to inhibit growth, and enhance apoptosis and IL‐2 mRNA synthesis in human lymphoblastic Jurkat T‐cells. In this study, two different butterfat types were evaluated and compared for their effects on Jurkat cell viability, oxidative stress, pro‐apoptotic activity, and cytokine synthesis: the conventionally produced butterfat (CBF), and organic butterfat (OBF) containing significantly higher amounts of c9,t11 (Rumenic Acid, RA), trans‐vaccenic acid (VA; t11‐18:1), α‐linolenic acid (ALA), and lower levels of linoleic acid (LA). Results from cell treatment with both butterfat mixtures showed comparable oxidative stress (superoxide production, intracellular GSH depletion,and lipid peroxides yield), NADPH oxidase activation, cytotoxicity (LDH release), and IL‐2 transcript level, whereas the effects of enhanced growth‐inhibitory and pro‐apoptotic activities were associated with OBF treatment. To then investigate each butterfat‐induced effect caused by RA, VA, LA, and ALA, cells were exposed to synthetic FA concentrations similar to those from the different butterfats. Higher oxidative stress (superoxide production, intracellular GSH depletion) was induced by α‐linolenic (ALA) and linoleic (LA) incubation (P < 0.01) and superoxide production was suppressed by specific PKCα inhibitor (Gö 6976) and linked to increased toxicity and IL‐2 synthesis inhibition. By contrast, cell treatment with RA increased apoptosis and IL‐2 synthesis. These results suggest that a supply of ALA and LA is responsible for BF‐induced oxidative stress via PKCα‐NADPH oxidase pathway, and that enhanced antiproliferative effects in OBF treated cells is essentially determined by RA‐induced pro‐apoptotic activity. © 2005 Wiley‐Liss, Inc.
Novel in vitro perfusion model to study the interaction between coagulation and blood‐borne metastasis
Authors: Sehgal Lakshman R. , Wong Jonathan , He Jie , Wood Trisha , Takagi Ippei , Eldibany Mohamed , Caprini Joseph , Mousa Shaker A. 
Published: July 2005

AbstractThe association between cancer and hemostasis has long been studied in cell culture, animal models, and cancer patients developing thrombosis. The variety of biologic mechanisms involved in malignancy and metastasis makes the understanding of the relative importance of each mechanism difficult. We have developed a novel in vitro perfusion model that allows for the isolated study of the interactions between tumor cells and components of the hemostatic system under normal physiologic conditions. Segments of denuded umbilical cord or saphenous vein are cut longitudinally and mounted in a perfusion chamber under sterile conditions. Human breast cancer cells are perfused for 24 h under venous flow conditions with either whole blood (WB), platelet‐rich plasma (PRP), platelet‐poor plasma (PPP), or serum. Tissue samples are fixed and stained with hematoxylin and eosin as well as with pan‐cytokeratin. Morphometric analysis is performed to quantify cancer cell adhesion. With PRP, this model maintains normal human physiologic conditions for the duration of the experiment. It differentiates between previously characterized high and low metastatic breast cancer cell lines. In addition, different vein tissue types do not alter tumor cell attachment. This model appears to be an accurate representation of the pathophysiology of in vivo metastasis. This model may serve as a useful bridge between cell culture studies and animal models. It may be a useful tool to elucidate the role of selected hemostatic systems in blood‐borne metastasis and may potentially serve as a screening tool for the development of antimetastatic pharmaceutical agents. © 2005 Wiley‐Liss, Inc.