bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUSEU E IDENTIDADE CULTURAL, A EXPERIÊNCIA DE UMA COMUNIDADE SUL BRASILEIRA
Authors: Callai Jaeme Luiz 
Published: December 2023

En la dinámica del proceso de atracción de inmigrantes europeos, al final del siglo XIX, se construyeron en Brasil diferentes experiencias de implantación de núcleos de poblamiento, denominados localmente, “colonias”. En estas “colonias” familias de origen europeo pasan a la condición de pequeños productores rurales en contacto con la sociedad local constituida de luso-brasileiros, afrodescendientes e indígenas.El texto discute cómo la diversidad de estos grupos étnico-nacionales europeos, en el contacto con la sociedad envolvente, organiza y reorganiza una nueva identidad. Ahora no más de “europeos” pero de brasileños portadores de una cultura diferenciada con especificidades resultantes de esta particular experiencia histórico social. Se considera aún la actuación educativa del museo local en este proceso de construcción identitaria.
Цифрова трансформація публічного сектора в забезпеченні регіонального партнерства
Authors: Антонова Ольга , Серьогін Сергій , Літвінов Олексій , Кривенкова Руслана 
Published: December 2023

В актуальності визначено відмінності цифровізації та цифрової трансформації, особливості цифрової трансформації в публічному управлінні заради забезпечення розвитку цифрової економіки.
Мета статті полягає у дослідженні підходів до формування цифрових екосистем в публічному секторі на регіональному рівні (від мережі партнерів та заінтересованих сторін, пріоритети розвитку держави, обслуговування споживачів, збір та обробка інформації, організаційна культура, базові компетентності лідерство та цифрові навички, середовище, досвід споживачів – клієнтський досвід, моделі робочого місця, час обробки звернення, обмеження ресурсів, підготовка фахівців, суміжність «готових» рішень і т.і.).
У результатах проаналізовано необхідність формування спільноти «розумних регіонів» як основного напряму впровадження цифрової економіки, наближення України до цифрового ринку ЄС. Вивчено еволюцію формування української національної коаліції цифрової трансформації. Проведено аналіз основних нормативно-правових документів та акцентовано увагу на діяльності заступників з питань цифрової трансформації. Доведено доцільність формування широких партнерств цифрового лідерства на регіональному, муніципальному рівнях. Відзначено активну роль громадських організацій у впровадженні цифрових навичок публічних службовців і цифрових амбасадорів для формування цифрового лідерства серед регіонів. Виокремлено важливу роль розвитку цифрової освіти та набуття цифрових компетентностей клієнтами-споживачами, обґрунтовано доцільність застосування клієнтського досвіду, брендування регіону як надійного роботодавця. Наведено стислий аналіз практики застосування індексу цифрової трансформації регіонів.
У висновках розроблено рекомендації з тенденцій регіональної цифрової трансформації: формування регіональних коаліцій цифрової трансформації для «готових рішень» для громад, застосування клієнтського досвіду, управління талантами, підвищення продуктивності та прогнозного аналізу поведінки споживача.
A educomunicação e a interface com o ensino remoto emergencial na especialização em docência para Educação Profissional, Científica e Tecnológica
Authors: Da Costa Waldelicy Lacerda 
Published: December 2023

O presente artigo tem o objetivo de compreender como a abordagem educomunicativa está presente nas práticas pedagógicas do Curso de Especialização em Docência para Educação Profissional, Científica e Tecnológica, do Instituto Federal do Pará (IFPA), Para a construção desse artigo identificou-se e discutiu-se as metodologias e os resultados de práticas pedagógicas desenvolvidas sob uma abordagem educomunicativa aplicadas no Curso de Especialização em Docência para Educação Profissional, Científica e Tecnológica do IFPA, Campus Breves, turma 2020, na modalidade de Ensino Remoto Emergencial (ERE).Campus Breves. Essas novas formas de trabalhar tanto presencialmente quanto na modalidade não presencial ou no Ensino emergencial Remoto, trazem consigo diversas formas de linguagens midiáticas que permitem expandir os conhecimentos acerca da educomunicação e metodologias ativas em tempos de pandemia, entretanto, a pesquisa demonstra que existem condições de exclusão digital no Marajó (aréa de abrangência do Campus Breves) dificultando o acesso dos estudantes as atividades pedagógicas virtuais.
Diagnostic value of endometrial samples in women with abnormal uterine bleeding at a teritiary care centre
Authors: Pidigundla Deepthi , Junutula Bhagyalakshmi , Naik V Sivasankara 
Published: December 2023

Abnormal uterine bleeding (AUB) is a most common gynecological complaint associated with co morbidities that affects quality of life in women. The Aim of the study was to ananlyze the hisopathological patterns of endometrium in women with AUB and to determine the various histopatterns among different age groups of women presenting with AUB. This is a prospective study conducted at Government medical college, Anantapuramu, from January 2021 to December 2022.Endometrial samples with clinical diagnosis of AUB, in whom Gestational causes were ruled out, were included in this study, Statistical data ananlysis was done using SSPS software. A total of 360 cases were analyzed. The prevalence of AUB most common in perimenopausal age group women. Mennorhagia (79.8%) was the common bleeding pattern. The bleeding pattern was significantly associated with age groups(p=0.00).The functional cause (64.2%) of AUB was more common than Organic cause (35.8%).The association of functional and organic causes with age group was not significant. The most common histological pattern was the normal cyclical pattern showing proliferative phase (54.1%). 94 cases showed hisopathological pattern of Hyperplasias that are more common among perimenopausal and postmenopausal age groups. Five cases of Endometrial carcinoma were seen among postmenopausal age group. Three cases were Stage IA, two cases were Stage IB. Obesity and hypertension were most common comorbid conditions seen in this study. Endometrial biopsy should be considered during the workup of women with a clinical diagnosis of AUB to exclude organic pathology especially early detection of precursor lesion of malignancy among perimenopausal and post-menopausal age groups.
Instytucje hybrydowe: próba wyodrębnienia w oparciu o wybrane przykłady ze świata kultury i gospodarki
Authors: Wdzięczak Janusz 
Published: December 2023

Celem eseju jest próba zdefiniowania nowego pojęcia instytucji hybrydowych. W tym celu autor dokonuje krótkiego przeglądu podstawowych pojęć, a następnie pokazuje przykłady „zgniłego kompromisu” pomiędzy porządkiem wolnorynkowym a porządkiem o charakterze etatystycznym.
Autor przytacza przykłady rzeczywistości ekonomicznej, które są egzemplifikacją instytucji hybrydowych, będących reliktem transformacji gospodarczej. Odnosi swoje obserwacje do wybranych teorii ekonomicznych, wskazując na konieczność utworzenia nowego pojęcia. Tekst ma charakter wstępny i programowy.
Mediating Role of Infidelity-related Posttraumatic Symptoms in the Relationship Between Forgiveness and Psychological Health Concerns
Authors: Tauy Jhunar John Magararo , Perez Jeannie Agustin 
Published: December 2023

Infidelity is one of the most common concerns in romantic relationships and is deemed morally unacceptable. Such event can be disruptive and may lead to negative consequences on well-being of betrayed individuals. This study examined the prevalence of infidelity-related posttraumatic symptoms and psychological health concerns (i.e., depression, anxiety, stress) among young adults who experienced infidelity by their partners. It also investigated whether forgiveness reduces the likelihood of psychological health concerns through lower levels of infidelity-related posttraumatic symptoms. It utilized a cross-sectional, predictive nonexperimental quantitative research design with n = 162 young adults, ages 19 – 40, who experienced being betrayed in a romantic relationship. The results showed that most of the respondents (93.21%) exceeded the cut-off score for probable post-traumatic stress disorder (PTSD), have severe depressive symptoms, anxiety symptoms, and stress. The respondents in this study reported a moderate degree of forgiveness. While controlling demographics and relationship history, the partial least squares structural equation modeling analysis showed that high degree of forgiveness tends to decrease psychological health concerns through lower levels of infidelity-related posttraumatic symptoms. The findings of this study highlighted the role of forgiveness in mental health outcomes which may lead to psychotherapeutic approaches incorporating this construct.
Administrative Liability for Discrediting the Activities of Public Authorities
Authors: Osintsev D. V. 
Published: December 2023

The subject of the analysis is the relations and activities of law enforcement agencies related to the qualification of administrative offenses aimed at discrediting the Armed Forces of the Russian Federation and state authorities in the context of unfriendly relations and armed confrontation between individual countries. Forces of the Russian Federation and public authorities in the conditions of unfriendly attitudes and armed confrontation of certain countries. The purpose of the study is to clarify the phenomenon of verbal and intensional offences of psycho-emotional type, the peculiarities of construction, design and deconstruction of the main elements of the composition of this type of administrative offences. Clarification of the criteria for the separation of conditionally lawful and categorically unlawful act expressed as a negative statement or aggressive unstable attitude of the psychological state of the person who committed an administrative offence also is the purpose of this paper. The research methods are based on the application of the legal text and correlation of the context of circumstances from the positions of the main provisions of propositional logic (derivation of categorical judgements about the meaning of certain terms with uncertain semantics (discrediting, publicity, targeting, etc.)). The doctrine of multiple predicates (which allowed building of matrix structures of admissibility of imputation of an unlawful act to a subject with a certain legal status only, as well as situational negation of admissibility of its imputation, if a full map of the subject's legal status is not available) is also used in the present research. Besides, design of modal constructions (rules of qualification of administrative offences of psycho-emotional type), as well as the logic of evaluations (in terms of weak and strong statements about prohibited or permissible statements about the activity of representatives of the authorities in certain conditions or in certain ways) is used as effective research method . The main conclusions of the study are expressed in the assertion of the priority establishment of amenability and punishability for offences related to the formation of destructive anti-cultural stereotypes, false ideological attitudes, belittling of the traditional way of life and denial of vital foundations of Russian society, the need to eliminate legal constructions with vague and unclear content. Increased attention should be paid to the semantic analysis and targeting of the offender's phrases precisely to replace the upheld public position with egoistic aspirations and planting the priority of personal misconceptions. It is necessary to introduce a separate category of rules of information and semantic analysis when imputing this or that administrative offence.
Role of mir-554 and mir-3117 in trigger and develop Non-small cell lung cancer
Authors: Afshinpour Maral , Ghamnak Faezeh Sojoudi , Salimi Alireza 
Published: December 2023

Abstract
Background: Lung cancer is known as one of the most common cancers worldwide. Non-small cell lung cancer (NSCLC) is found in 85% of cases of lung cancer. In this study, we tried to identify genes that can be used to prevent cancer from progressing by inhibiting their expression by microRNAs. These gels can be targeted as a treatment.
Method: In this study, using the data obtained from the article, 37 genes were finally reached with the Venny 2.1 database. We then analyzed the genes involved in lung cancer, using databases such as DAVID, PANTHER, and ENRICHER.
Results: Our work provides insight into PDGFRA, LAMC1, and MAP3K8 have critical roles in important pathways and biological processes which can develop cancer such as; angiogenesis, integrin signaling pathway, and development process. for the first time, mir-554 and mir-3117plays a critical role by inhibiting the proto- oncogene genes map3k8, PDGFR and lamc1.
Long non-coding RNAs underlie multiple domestication traits and leafhopper resistance
Authors: Ma Jianxin , Wang Weidong , Duan Jingbo , Wang Xutong , Feng Xingxing , Chen Liyang , Clark Chancelor , Swarm Stephen , Wang Jinbin , Lin Sen , Nelson Randall , Meyers Blake , Feng Xianzhong 
Published: December 2023

Abstract

The origination and functionality of long non-coding RNAs (lncRNAs) remain poorly understood. Here, we show that multiple quantitative trait loci modulating distinct domestication traits in soybeans are pleiotropic effects of a locus composed of two tandem lncRNA genes. These lncRNA genes, each containing two inverted repeats (IRs) originated from coding sequences of MYB genes, function by generating clusters of small RNAs in wild soybeans to inhibit the expression of their MYB gene relatives through posttranscriptional regulation. In contrast, the expression of the lncRNA genes in cultivated soybeans is severely repressed, and consequently, the corresponding MYB genes are highly expressed, shaping multiple distinct domestication traits as well as leafhopper resistance. The IRs were formed before the divergence of the Glycine genus from the Phaseolus/Vigna lineage and exhibit strong structure-function constraints. This study exemplifies a new type of targets for selection during plant domestication and uncovers mechanisms of lncRNA formation and action.
Quality evaluation of effective abrasive micro-edge honing based on Tra-FAH and SPA
Authors: Yu Yue , Liang Yuan , Liu Lin , Su Jie , Wang Fuwei , Zhou Jian cong , 高 阳 
Published: December 2023

Abstract
CNC powerful gear honing can comprehensively improve the tooth surface performance and is widely used in the finishing process of high-performance gears in the transmission system of new energy vehicles. Accurate evaluation of gear honing processing quality has important engineering application value for popularizing the process of "honing instead of grinding". In this paper, 12 factors, such as abrasive particle size, are determined qualitatively by analyzing the factors affecting gear honing accuracy, tooth surface quality and machining efficiency. Based on trapezoidal fuzzy analytic hierarchy process (Tra-FAH) and set pair analysis method (SPA), a quantitative evaluation model of CBN abrasive micro edge honing quality is established. Through the influence factor weight and key factor sensitivity analysis, it is quantitatively determined that the honing process parameters and abrasive particle size, abrasive particle shedding, abrasive particle breakage and other factors are the key factors affecting the honing quality. Taking the particle size factor as an example, the machining experiment and analysis show that the model can correctly evaluate the honing quality of high quality hardened gears and can be used to study the mechanism of honing characteristics and improve the comprehensive quality of powerful gear honing.
Effects of the Shielding Gas and Substrate Thickness on Dilution and Microstructure of Inconel® 625 MIG/MAG Welded Coatings
Authors: Macedo Rodrigo Jorge , Celente Cristiano de Azevedo , Souza Daniel , Costa Henara Lillian 
Published: December 2023

Abstract

Inconel® 625 alloy is a corrosion-resistant nickel-based superalloy, often deposited onto cheaper substrates due to its high cost. In this research, deposition of Inconel 625 was carried out by MIG/MAG (Metal Inert Gas/Metal Active Gas) welding process due to its ease of operation, automation and productivity. The main purpose of this work is to evaluate the shielding gas and substrate thickness on the cooling rate, dilution and microstructure of Inconel® 625 coatings welded by the MIG/MAG process. The cooling rate during deposition was measured using thermocouples. Dilution was evaluated from macrographs of cross section of the welded coatings using Image J software. The microstructure of the coatings was assessed via SEM/EDS (Scanning Electron Microscope/Energy Dispersive Spectroscopy) and X-ray diffraction (XRD). The results showed that cooling rates were higher for plates welded with Ar + 25% He, leading to lower dilution. In the microstructure, a γ-Ni matrix with precipitated phases of Mo and Nb was identified.
Data Mining of Electronic Health Records to Identify Undiagnosed Patients with Rare Genetic Diseases
Authors: Moynihan Daniel , Monaco Sean , Ting Teck Wah , Narasimhalu Kaavya , Hsieh Jenny , Kam Sylvia , Lim Jiin Ying , Lim Weng Khong , Davila Sonia , Bylstra Yasmin , Balakrishnan Iswaree Devi , Heng Mark , Chia Elian , Yeo Khung Keong , Goh Bee Keow , Gupta Ritu , Tan Tele , Baynam Gareth , Jamuar Saumya Shekhar 
Published: December 2023

Abstract
Rare genetic diseases affect 5-8% of the population but are often undiagnosed or misdiagnosed. Electronic health records (EHR) contain large amounts of data, which provide opportunities for analysing and mining. Data mining was performed on a database containing deidentified health records of 1.28 million patients across 3 major hospitals in Singapore, in a bid to improve the diagnostic process for patients who are living with an undiagnosed rare disease, specifically focusing on Fabry Disease and Familial Hypercholesterolaemia (FH). On a baseline of 4 patients, we identified 2 additional patients with potential diagnosis of Fabry disease, suggesting a 50% increase in diagnosis. Similarly, we identified >12,000 individuals who fulfil the clinical and laboratory criteria for FH, suggesting that data mining of EHR may allow for increased diagnosis of patients with rare disorders. This proof-of-concept study showed that it is indeed possible to perform data mining on EHR albeit with some challenges and limitations.
VIRMA-mediated m6A modification is essential for active ribosome biogenesis
Authors: Zhou Tao , Wu Min , Wu Xiaoli , Sun Haifeng , Wang Wen , Zhang Leyi , Liu Xia , Zhang Yifan , Zhang Xinning , Liu Jun , Shen Bin 
Published: December 2023

Abstract
N6-methyladenosine (m6A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m6A modification and their impact on protein synthesis machinery remain unclear. VIRMA, the largest and evolutionarily conserved core of the m6A methyltransferase complex, is highly expressed in the embryonic brain and various cancers. Here, we demonstrate that VIRMA-mediated m6A modification is essential for active ribosome biogenesis. VIRMA depletion destabilizes the entire writer complex and reduces m6A levels, leading to decreased proliferation and increased apoptosis of neural progenitor/stem cells (NPCs), ultimately causing severe forebrain developmental defects. Mechanistically, VIRMA depletion impairs ribosome biogenesis by inhibiting mRNA decay, triggering a P53-dependent ribosomal stress response and compromising global protein synthesis. Importantly, these findings extend to human cancer cells, suggesting the conservation of this mechanism. Overall, our study reveals the critical role of m6A in adapting protein synthesis machinery during brain development and in cancer.
Repeat drug-coated balloon angioplasty for femoropopliteal lesions: 12-month results from a retrospective observational study
Authors: Haraguchi Takuya , Tsujimoto Masanaga , Kashima Yoshifumi , Sato Katsuhiko , Fujita Tsutomu 
Published: December 2023

Abstract
Background: The clinical implications of restenosis after drug-coated balloon (DCB) treatment remain unclear. We compared the clinical outcomes between DCB angioplasty for restenosis and de novo femoropopliteal artery lesions. This single-center retrospective study included 571 patients (737 limbs) who underwent either repeat (54 patients, 64 limbs) or de novo DCB (517 patients, 673 limbs) without bailout stenting. After propensity score matching, 49 matched pairs were analyzed. The primary endpoint was the 1-year primary patency, with secondary endpoints including the freedom from target lesion revascularization (TLR), major adverse limb events (MALE), and early restenosis.
Results: The repeat-DCB group displayed significantly lower rates of 1-year primary patency and freedom from TLR compared to those of the de novo-DCB group (50.1% vs. 77.4%, p=0.029 and 54.9% vs. 83.6%, p=0.0.44, respectively). No significant differences were observed in early restenosis or MALE (10.7% vs. 5.9%, p=0.455 and 48.3% vs. 73.4%, p=0.055, respectively). Restenosis after DCB angioplasty was associated with repeat DCB (hazard ratio [HR], 5.13; 95% confidence interval [CI], 1.43–18.4; p=0.012) and small vessel size of <4.5 mm (HR, 6.25; 95% CI, 1.17–33.4; p=0.032). Furthermore, restenosis after repeat DCB angioplasty was associated with the Peripheral Artery Calcification Scoring System (PACSS) grade 4 (HR, 4.20; 95% CI, 1.08–16.3; p=0.038), small vessel size of <4.5 mm (HR, 9.44; 95% CI, 1.21–73.7; p=0.032), and intravascular ultrasound (IVUS) use (HR, 0.05; 95% CI, 0.01–0.44; p=0.007).
Conclusions: The 1-year primary patency rate following repeat DCB angioplasty for femoropopliteal lesions was notably lower than that of DCB treatment for de novo lesions. Repeat DCB strategy was associated with an increased risk of patency loss. Regarding repeat restenosis after DCB treatments, PACSS grade 4 calcification and small vessel diameter of <4.5 mm were associated with an increased risk of restenosis, whereas IVUS use correlated with a decreased risk of restenosis.
Co-option and neofunctionalization of stomatal executors for defense against herbivores in Brassicales
Authors: Shirakawa Makoto , Oguro Tomoki , Sugano Shigeo , Yamaoka Shohei , Sagara Mayu , Tanida Mai , Sunuma Kyoko , Iwami Takuya , Nakanishi Tatsuyoshi , Horiuchi Keita , Kumaishi Kie , Yoshida Soma , Watanabe Mutsumi , Tohge Takayuki , Suzuki Takamasa , Ichihashi Yasunori , Takemiya Atsushi , Yamaguchi Nobutoshi , Kohchi Takayuki , Ito Toshiro 
Published: December 2023

Abstract

Co-option of gene regulatory networks leads to the acquisition of new cell types and tissues. Stomata, valves formed by guard cells (GCs), are present in most land plants and regulate CO2 exchange. The transcription factor (TF) FAMA globally regulates GC differentiation but also promotes the development of idioblast myrosin cells (MCs), another type of specialized cell along the vasculature essential for Brassicales-specific chemical defenses. Here, we show that the TF gene WASABI MAKER (WSB), directly induced by FAMA, triggers MC differentiation. WSB and STOMATAL CARPENTER 1 (SCAP1), a stomatal lineage–specific direct FAMA target, synergistically promote GC differentiation. wsb mutants lacked MCs, while the wsb scap1 double mutant lacked normal GCs. Evolutionary analyses revealed that WSB is conserved across stomatous angiosperms. Furthermore, the FAMA–WSB positive feedback loop acts as a cell fate switch. We propose that the conserved and reduced transcriptional FAMA–WSB module was co-opted before evolving to induce MC differentiation.