bluuebunny/crossref_metadata_2025_split huggingface dataset:
High day and night temperatures impact on cotton yield and quality—current status and future research direction
Authors: Saini Dinesh K. , Impa S. M. , McCallister Donna , Patil Gunvant B. , Abidi Noureddine , Ritchie Glen , Jaconis S. Y. , Jagadish Krishna S. V. 
Published: October 2023

AbstractHeat waves, and an increased number of warm days and nights, have become more prevalent in major agricultural regions of the world. Although well adapted to semi-arid regions, cotton is vulnerable to high temperatures, particularly during flowering and boll development. To maintain lint yield potential without compromising its quality under high-temperature stress, it is essential to understand the effects of heat stress on various stages of plant growth and development, and associated tolerance mechanisms. Despite ongoing efforts to gather data on the effects of heat stress on cotton growth and development, there remains a critical gap in understanding the distinct influence of high temperatures during the day and night on cotton yield and quality. Also, identifying mechanisms and target traits that induce greater high day and night temperature tolerance is essential for breeding climate-resilient cotton for future uncertain climates. To bridge these knowledge gaps, we embarked on a rigorous and comprehensive review of published literature, delving into the impact of heat stress on cotton yields and the consequential losses in fiber quality. This review encompasses information on the effects of heat stress on growth, physiological, and biochemical responses, fertilization, cotton yield, and quality. Additionally, we discuss management options for minimizing heat stress-induced damage, and the benefits of integrating conventional and genomics-assisted breeding for developing heat-tolerant cotton cultivars. Finally, future research areas that need to be addressed to develop heat-resilient cotton are proposed.
Are dogs not susceptible to retroviral infections?
Authors: Casseb Jorge , Campos João Henrique , Lopes Luciano Rodrigo 
Published: October 2023

AbstractRetroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments to understand why dogs may have not been infected by retroviruses thus far. The potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question, looking at some evolutive aspects. The lineage of canids has shown, throughout its evolutionary history, a smaller accumulation of retroviruses in canid genomes, classified as endogenous retroviruses. In this context, the genomes of canids seem to offer obstacles, which have been evolutionarily conserved, in the face of retroviral infection.
A MinION-based Long-Read Sequencing Application With One-Step PCR for the Genetic Diagnosis of 21-Hydroxylase Deficiency
Authors: Adachi Eriko , Nakagawa Ryuichi , Tsuji-Hosokawa Atsumi , Gau Maki , Kirino Shizuka , Yogi Analia , Nakatani Hisae , Takasawa Kei , Yamaguchi Tomomi , Kosho Tomoki , Murakami Masanori , Tajima Toshihiro , Hasegawa Tomonobu , Yamada Tetsuya , Morio Tomohiro , Ohara Osamu , Kashimada Kenichi 
Published: October 2023

Abstract

Context
Recently developed long-read sequencing (LRS) technology has been considered an option for CYP21A2 analysis. However, the clinical use of LRS for CYP21A2 analysis is limited.

Objective
This study's objective is to develop an efficient and low-cost LRS system for CYP21A2 screening.

Methods
A DNA fragment library was prepared in a single polymerase chain reaction (PCR) that covers the entire CYP21A2 gene and all known junctions caused by TNXB gene structural rearrangements, yielding a single 8-kb product of CYP21A2 or CYP21A1P/CYP21A2 chimera. After barcoding, the PCR products were sequenced on a MinION-based platform with Flongle Flow Cell R9.4.1 and R10.4.1.

Results
The reference genotypes of 55 patients with 21-hydroxylase deficiency (21OHD) were established using the conventional method with multiplex ligation-dependent probe amplification (MLPA) and nested PCR. LRS using Flongle Flow Cell R9.4.1 yielded consistent results. Additionally, the recently updated LRS “duplex” analysis with Flongle flow cell R10.4.1 was tested to reveal an advantage of accurately sequencing a variant located on the homopolymer region. By introducing a barcode system, the cost was reduced to be comparable to that of conventional analysis. A novel single-nucleotide variation was discovered at the acceptor site of intron 7, c.940-1G &gt; C. We also identified a subtype of the classical chimeric junction CH2, “CH2a,” in the region from the latter part of intron 5 to exon 6.

Conclusion
We successfully established a novel low-cost and highly accurate LRS system for 21OHD genetic analysis. Our study provides insight into the feasibility of LRS for diagnosing 21OHD and other genetic diseases caused by structural rearrangements.
Diabetic Macular Edema Is Predictive of Renal Failure in Patients With Diabetes Mellitus and Chronic Kidney Disease
Authors: Ou Shih-Hsiang , Chang Wei-Che , Wu Ling-Ying , Wang Shiow-Ing , Wei James Cheng-Chung , Lee Po-Tsang 
Published: October 2023

Abstract

Context
Chronic hyperglycemia in patients with diabetes mellitus (DM) causes retinal damage and leakage, resulting in vision loss. Although diabetic retinopathy (DR) and diabetic kidney disease (DKD) are usually correlated, the relationship between diabetic macular edema (DME) and DKD remains unknown.

Objective
To assess whether DME presence can predict renal failure in patients with DM and chronic kidney disease (CKD).

Methods
This retrospective cohort study used data from 120 healthcare organizations in the TriNetX network. Electronic medical records of approximately 90 million patients were reviewed. The study population was classified into DME and non-DME cohorts. Primary and secondary outcomes were new-onset end-stage renal disease (ESRD) and all-cause mortality, respectively. Covariate factors were incorporated to reduce confounding effects.

Results
Before matching, the DME cohort used more medication and had poorer renal function and blood sugar control than the non-DME cohort. Subsequently, the 2 groups were well-matched in demographics, socioeconomic status, lifestyle, comorbidities, and medication usage. The DME cohort had a significantly higher risk of ESRD, dialysis, and renal transplantation than the non-DME cohort. Subgroup analyses showed consistent results irrespective of follow-up duration, initial estimated glomerular filtration rate, or glycated hemoglobin levels. Additionally, the DME cohort had a lower risk of all-cause mortality than the non-DME cohort.

Conclusion
Statistically significant 5-year increased risks of ESRD, dialysis, and renal transplantation were observed in patients with concurrent DME. Therefore, close monitoring and follow-up of the renal function in DM patients with DME are necessary and strongly recommended.
Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome
Authors: Golden Emma , van der Heijden Hanne , Ren Boyu , Randall Edin T , Drubach Laura A , Shah Nehal , Cay Mariesa , Ebb David , Kaban Leonard B , Peacock Zachary S , Boyce Alison M , Mannstadt Michael , Upadhyay Jaymin 
Published: October 2023

Abstract

Context
Pain is a poorly managed aspect in fibrous dysplasia/McCune-Albright syndrome (FD/MAS) because of uncertainties regarding the clinical, behavioral, and neurobiological underpinnings that contribute to pain in these patients.

Objective
Identify neuropsychological and neurobiological factors associated with pain severity in FD/MAS.

Design
Prospective, single-site study.

Patients
Twenty patients with FD/MAS and 16 age-sex matched healthy controls.

Intervention
Assessments of pain severity, neuropathic pain, pain catastrophizing (pain rumination, magnification, and helplessness), emotional health, and pain sensitivity with thermal quantitative sensory testing. Central nervous system (CNS) properties were measured with diffusion tensor imaging, structural magnetic resonance imaging, and functional magnetic resonance imaging.

Main outcome measures
Questionnaire responses, detection thresholds and tolerances to thermal stimuli, and structural and functional CNS properties.

Results
Pain severity in patients with FD/MAS was associated with more neuropathic pain quality, higher levels of pain catastrophizing, and depression. Quantitative sensory testing revealed normal detection of nonnoxious stimuli in patients. Individuals with FD/MAS had higher pain tolerances relative to healthy controls. From neuroimaging studies, greater pain severity, neuropathic pain quality, and psychological status of the patient were associated with reduced structural integrity of white matter pathways (superior thalamic radiation and uncinate fasciculus), reduced gray matter thickness (pre-/paracentral gyri), and heightened responses to pain (precentral, temporal, and frontal gyri). Thus, properties of CNS circuits involved in processing sensorimotor and emotional aspects of pain were altered in FD/MAS.

Conclusion
These results offer insights into pain mechanisms in FD/MAS, while providing a basis for implementation of comprehensive pain management treatment approaches that addresses neuropsychological aspects of pain.
Plasma Sphingolipid Profile of Healthy Black and White Adults Differs Based on Their Parental History of Type 2 Diabetes
Authors: Mandal Nawajes , Stentz Frankie , Asuzu Peace Chiamaka , Nyenwe Ebenezer , Wan Jim , Dagogo-Jack Sam 
Published: October 2023

Abstract

Context
Ceramides and sphingolipids have been linked to type 2 diabetes (T2D). The Ceramides and Sphingolipids as Predictors of Incident Dysglycemia (CASPID) study is designed to determine the association of plasma sphingolipids with the pathophysiology of human T2D.

Objective
A comparison of plasma sphingolipids profiles in Black and White adults with (FH+) and without (FH−) family history of T2D.

Design
We recruited 100 Black and White FH− (54 Black, 46 White) and 140 FH+ (75 Black, 65 White) adults. Fasting plasma levels of 58 sphingolipid species, including 18 each from 3 major classes (ceramides, monohexosylceramides, and sphingomyelins, all with 18:1 sphingoid base) and 4 long-chain sphingoid base–containing species, were measured by liquid chromatography/mass spectrometry.

Results
Sphingomyelin was the most abundant sphingolipid in plasma (89% in FH−), and was significantly elevated in FH+ subjects (93%). Ceramides and monohexosylceramides comprised 5% and 6% of total sphingolipids in the plasma of FH− subjects, and were reduced significantly in FH+ subjects (3% and 4%, respectively). In FH+ subjects, most ceramide and monohexosylceramide species were decreased but sphingomyelin species were increased. The level of C18:1 species of all 3 classes was elevated in FH+ subjects.

Conclusion
Elevated levels of sphingomyelin, the major sphingolipids of plasma, and oleic acid–containing sphingolipids in healthy FH+ subjects compared with healthy FH− subjects may reflect heritable elements linking sphingolipids and the development of T2D.
Multivariable Model to Predict an ACTH Stimulation Test to Diagnose Adrenal Insufficiency Using Previous Test Results
Authors: Lawrence Neil Richard , Arshad Muhammad Fahad , Pofi Riccardo , Ashby Sean , Dawson Jeremy , Tomlinson Jeremy W , Newell-Price John , Ross Richard J , Elder Charlotte J , Debono Miguel 
Published: October 2023

Abstract

Context
The adrenocorticotropin hormone stimulation test (AST) is used to diagnose adrenal insufficiency, and is often repeated in patients when monitoring recovery of the hypothalamo–pituitary–adrenal axis.

Objective
To develop and validate a prediction model that uses previous AST results with new baseline cortisol to predict the result of a new AST.

Methods
This was a retrospective, longitudinal cohort study in patients who had undergone at least 2 ASTs, using polynomial regression with backwards variable selection, at a Tertiary UK adult endocrinology center. Model was developed from 258 paired ASTs over 5 years in 175 adults (mean age 52.4 years, SD 16.4), then validated on data from 111 patients over 1 year (51.8, 17.5) from the same center, data collected after model development. Candidate prediction variables included previous test baseline adrenocorticotropin hormone (ACTH), previous test baseline and 30-minute cortisol, days between tests, and new baseline ACTH and cortisol used with calculated cortisol/ACTH ratios to assess 8 candidate predictors. The main outcome measure was a new test cortisol measured 30 minutes after Synacthen administration.

Results
Using 258 sequential ASTs from 175 patients for model development and 111 patient tests for model validation, previous baseline cortisol, previous 30-minute cortisol and new baseline cortisol were superior at predicting new 30-minute cortisol (R2 = 0.71 [0.49-0.93], area under the curve [AUC] = 0.97 [0.94-1.0]) than new baseline cortisol alone (R2 = 0.53 [0.22-0.84], AUC = 0.88 [0.81-0.95]).

Conclusion
Results of a previous AST can be objectively combined with new early-morning cortisol to predict the results of a new AST better than new early-morning cortisol alone. An online calculator is available at https://endocrinology.shinyapps.io/sheffield_sst_calculator/ for external validation.
Association of diagnostic error education and recognition frequency among Japanese medical students: a nationwide cross-sectional study
Authors: Miyagami Taiju , Watari Takashi , Nishizaki Yuji , Shimizu Taro , Tokuda Yasuharu 
Published: October 2023

Abstract

Objectives
Diagnostic errors pose a significant risk to patient safety and have substantial medical and economic consequences. Despite their importance, diagnostic error education is currently lacking in standard pre-graduate curricula. This study aimed to investigate the incidence of diagnostic errors and the frequency of recognition among medical students in Japan.

Methods
A pilot survey was conducted immediately after the General Medicine In-Training Examination (GM-ITE), a comprehensive post-graduation test, administered to new residents right after graduation from medical school. The survey assessed whether they received education on diagnostic errors during their formal undergraduate medical education and whether they recognized diagnostic errors during their clinical training.

Results
Of the 564 examinees, 421 participated in the study. The majority of participants (63.9 %) reported receiving education on diagnostic errors, and 15.7 % recognized diagnostic errors during their clinical training. Significantly, those who received education on diagnostic errors had a higher rate of recognizing such errors compared to those who did not (19.7 vs. 8.6 %; p=0.0017).

Conclusions
These findings suggest that the recognition rate of diagnostic errors increases with improved literacy in diagnostic error education. This highlights the importance of incorporating diagnostic error education into medical curricula to develop effective strategies to prevent and manage diagnostic errors, and thereby enhance medical and patient safety. However, this study did not examine the specific educational content of the errors or the details of the recognition, necessitating further investigation in the future.
Fingerprint of magma mixture in the leucogranites: Spectroscopic and petrochemical approach, Kalebalta-Central Anatolia, Türkiye
Authors: Güllü Bahattin , Akşit Asuman 
Published: October 2023

Abstract
Leucogranites of Kalebalta in Central Anatolia are composed of plagioclase, quartz, orthoclase, and biotite and contains mafic microgranular enclaves (MME) in sizes ranging from few cm to 70 cm. In the total alkali-silica diagram, they fall typically in the granite field and show a calc-alkaline nature in the alkalis-iron-magnesium diagram whereas enclaves are Medium K series calc-alkaline, which represents the transition from tholeiitic to calc-alkaline. Leucogranites which have A/CNK(mol%) > 1 are strong peraluminous and seen as the products of magma derived from a metasedimentary source. Signs of magma mixing expressing the mantle inputs are also observed in many bivariation diagrams. Zircon and apatite saturation temperatures calculated on the basis of whole rock chemistry are 744–829°C for leucogranites and 761–832°C for their enclaves. According to the Raman spectra, biotite and plagioclase minerals in leucogranites and their enclaves show similar Raman spectrums. The biotite minerals have Mg–O and/or Fe–O translational (transformation) bonds between 182 and 552 cm−1, Si–O–Si bending between 552 and 1,100 cm−1 and Si–O–Si vibrational bonds between 1,100 and 1,200 cm−1. The results of this study suggest that the leucogranites and enclaves are most probably derived from different magmas. In addition, according to geochemical and spectroscopic data, they may also have fractional crystallization, which is effective after the mixing process.
A frequency, coverage, and dispersion analysis of the academic collocation list in university student writing
Authors: Huang Ping-Yu 
Published: October 2023

Abstract
This study investigates whether cross-disciplinary academic collocation lists are of equal importance to EAP (English for academic purposes) learners across different disciplines. We target Ackermann and Chen’s (Ackermann, Kirsten & Yu-Hua Chen. 2013. Developing the Academic Collocation List (ACL)–A corpus-driven and expert-judged approach. Journal of English for Academic Purposes 12(4). 235–247) Academic Collocation List (ACL) and conduct a frequency, coverage, and dispersion analysis of its 2,464 pairs in the British Academic Written English (BAWE) corpus. Using BAWE data, we also examine whether university students increase use of academic collocations across years. Generally, our results indicate that cover-all academic collocation lists, like academic word lists, show uneven frequency distributions across disciplines; the ACL covers considerably more word combinations in soft than hard sciences. According to our dispersion analysis, furthermore, an important cause for such skewed distributions is that a substantial part of the ACL (i.e., almost 25 %) is in actuality discipline-specific rather than generic collocations. In terms of collocation development, we do observe steady increases across years. Interestingly, university students throughout levels not only use more academic collocations, but display a stronger tendency to raise the proportion of discipline-specific collocations in writing. This study is novel as it systematically examines distributions and developments of academic collocations, and is pedagogically valuable in that it collects 483 ACL entries which are suitable targets for EAP learning.
Nanocoatings for ballistic applications: A review
Authors: Biradar Anand , Arulvel S. , Kandasamy Jayakrishna , Hameed Sultan Mohamed Thariq , Shahar Farah Syazwani , Najeeb Muhammad Imran , Gaff Milan , Hui David 
Published: October 2023

Abstract
The manufacturing of ballistic impact-resistant (BIR) body armours has evolved over the years with the aim of reducing their weight and enhancing their energy-absorbing capacity upon ballistic impacts. The incorporation of nanoparticles into advanced BIR body armour systems is considered one of the promising techniques. The methods employed in incorporating various nanoparticles in the manufacturing of textile-based body armour systems face a research gap in the optimisation of the associated parameters. This article discusses the mechanism involved in the energy absorption of composites and nanocomposites upon ballistic impact. The current review article highlights the chemical, physical, and mechanical properties of various nanoparticles incorporated into BIR body armour systems. BIR nanocomposites consisting of carbon nanotubes, graphene nanoplatelets, nano-silica, nanoclays, nano-alumina, etc., have been discussed herein. In addition, the significance of various techniques for the dispersion of these nanoparticles was also highlighted. Various methods, such as sol–gel, PVD, CVD, thermal spray, and electroless methods for coating the nanoparticles on the surface of the fibre/fabric were also discussed.
Nonsequential double ionization channels control of CO2 molecules with counter-rotating two-color circularly polarized laser field by laser wavelength
Authors: Ge Zhenjie , Bai Lihua , Su Xu , Liu Keying 
Published: October 2023

Abstract
Using the classical ensemble model, we investigate the effect of laser wavelength on the electron dynamics process of nonsequential double ionization (NSDI) for linear triatomic molecules driven by a counter-rotating two-color circularly polarized laser field. Based on the delay time between recollision and final double ionization, two particular ionization channels are separated: recollision-impact ionization (RII) and recollision-induced excitation with subsequent ionization (RESI). Numerical results show that with the increase of the laser wavelength, the triangle structure of the ion momentum distribution becomes more obvious, which indicates that the electron–electron correlation of NSDI is enhanced. In addition, we find that the ratio of the RESI channel gradually decreases with the increase of the laser wavelength, while the ratio of the RII channel is opposite. However, the dominant channel is still RESI. It means that the two ionization channels can be controlled effectively by changing the laser wavelength.
The transmittance properties of the one-dimensional gyroidal superconductor photonic crystals
Authors: Elsayed Hussein A. , Mishra Chandra Sekhar , Almawgani Abdulkarem H. M. , Ali Yahya Ali Abdelrahman , Mehaney Ahmed 
Published: October 2023

Abstract
In this study, the transfer matrix method is used to analyze the optical properties of a layered structure, {Air(SrTiO3/BSCCO)20Substrate}, consisting of air, SrTiO3, BSCCO (bismuth strontium calcium copper oxide) bilayers, and a substrate. This paper aims to investigate the transmittance spectra of two proposed one-dimensional (1D) structures, including a conventional superconductor photonic crystal (PC) and a gyroidal superconductor PC at infrared (IR) wavelengths. A comprehensive analysis has been carried out to provide useful insights into the optical properties and the behavior of the proposed structure, highlighting the impact of many parameters, such as refractive index, filling fraction, and layer thickness. The numerical findings showed that the permittivity of the BSCCO superconductor of a gyroidal geometry takes a different response compared to the conventional one. Notably, the filling fraction and refractive index of the host material have a significant control on both real and imaginary parts of the gyroidal BSCCO permittivity through the considered wavelengths. Thus, the proposed design provides high transmittivity outside the obtained photonic band gap compared to the conventional one. We believe that the designed one-dimensional gyroidal BSCCO photonic crystals could act as an efficient reflector through near IR for optoelectronics and energy applications.