bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strength of bolted steel structural members under eccentric tension
Authors: Nagasato Kazuma , Ikarashi Kikuo , Mitsui Kazuya 
Published: October 2023

AbstractThe effective cross‐sectional area method for the outstanding leg is utilized as an ineffective area to evaluate the strength in the present Japanese design standard. Given that this evaluation method is fundamentally premised on experimental outcomes derived from relatively thick plates, it must be extended to brace members composed of thin plates. In this study, we conduct bolt joint experiments and numerical analyses on thin‐plate angles and channel members, with the aim to elucidate the elements influencing the efficiency of the joint. We propose a unified bolt joint strength evaluation formula that also considers thin‐plate members.
High‐resolution MR neurography follow‐up of SARS‐CoV‐2 vaccination‐associated neuralgic amyotrophy
Authors: Mooshage Christoph M. , Kele Henrich , Bendszus Martin , Schwarz Daniel 
Published: October 2023

AbstractLittle is known about the value of high‐resolution follow‐up imaging in patients with neuralgic amyotrophy (NA) and the question of the best treatment algorithm remains unclear. Three patients (one female, two male) with the clinical presentation of SARS‐CoV‐2‐vaccination‐associated NA underwent initial magnetic resonance neurography (MRN) imaging and follow‐up examinations. All patients showed a marked clinical improvement, independent of treatment, including an almost full recovery of motor function over the course of 8–12 months which was accurately mirrored by imaging findings on MRN. MRN imaging is a valuable tool for monitoring the further clinical course of patients suffering from vaccination‐associated NA.
Radioiodine‐131‐Labeled Theranostic Nanoparticles for Transarterial Radioembolization and Chemoembolization Combination Therapy of VX2 Liver Tumor
Authors: Jia Guorong , Wang Tao , Li Rou , Li Xiao , Sun Gaofeng , Chen Wei , Peng Ye , Cheng Chao , Yang Jijin , Zuo Changjing 
Published: October 2023

AbstractIn interventional treatment, materials are administered into the blood supply artery and directly delivered to tumors, offering proper scenarios for nanomedicine potential clinical applications. Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are effective treatment methods for hepatocellular carcinoma (HCC), but postoperative residual tumor may result in intrahepatic recurrence and distant metastasis. The combination therapy of TACE and TARE based on multifunctional nanoparticles (NPs) is expected to overcome the drug resistance in hypoxic tumors and improve the therapeutic effect. Herein, BaGdF5 NPs are synthesized and then coated with polydopamine (PDA), conjugated with the chemotherapeutic drug cis‐diamminedichloride platinum (CDDP), radio‐labeled with therapeutic radionuclide 131I, yielding 131I‐BaGdF5@PDA‐CDDP NPs. The in vitro anti‐cancer effects of 131I‐BaGdF5@PDA‐CDDP NPs are confirmed using CCK‐8 and γ‐H2AX assays in Huh7 cells. Mixed with Lipiodol, 131I‐BaGdF5@PDA‐CDDP NPs are injected into the hepatic artery via a microcatheter to realize the TACE and TARE combination therapy in a rabbit VX2 liver tumor model. The results indicate that glucose metabolism is clearly decreased based on 18F‐FDG PET imaging and the apoptosis of tumor cells is increased. Furthermore, 131I and BaGdF5 NPs can be used for SPECT imaging and CT/MR imaging respectively, facilitating real‐time monitoring of the in vivo biodistribution of 131I‐BaGdF5@PDA‐CDDP NPs.
Zwitterion‐conjugated Topological Glycomimics for Dual‐Blocking Effects to Eradicate Biofilm Infection
Authors: Guo Qianqian , Cheng Yijie , Fan Zheng , Wu Weihui , Wu Zhongming , Zhang Xinge 
Published: October 2023

AbstractP. aeruginosa, a leading nosocomial pathogen, commonly causes chronic biofilm infections in tissues and biomedical devices, including wound infections, osteomyelitis, and infective endocarditis, heavily threatening life. The dynamic lifecycle of these biofilms leads to persistent generation, making it challenging to prevent and disperse these biofilms effectively. Herein, a topological eight‐arm zwitterion‐conjugated glycomimetics (PCBAA‐b‐PLAMA)8 to address this challenge by exerting a dual‐blocking effect on P. aeruginosa biofilms is introduced. Initially, carboxybetaine acrylate (CBAA) and 2‐lactobionamidoethyl methacrylate (LAMA) are introduced to the topological bromine‐based initiator to prepare (PCBAA‐b‐PLAMA)8. This copolymer demonstrats remarkable efficiency in dispersing P. aeruginosa biofilms, approximately up to 99%. This high efficacy can be attributed to the multivalent and triaxial interactions between LAMA and CBAA groups, which enable the capture of P. aeruginosa cells and the biofilm matrix. Furthermore, (PCBAA‐b‐PLAMA)8 efficiently inhibit the expression of resistance genes related to biofilm formation and antibiotic efflux, including cdrA, lasB, mexE, and mexH, regaining bacterial cell sensitivity to antibiotics and further facilitating the natural dispersal of biofilms. This study provides a generic dual‐blocking strategy for the efficient eliminating of biofilms from biomedical devices.
Genome‐wide association analysis of coleoptile length and interaction with plant height in durum wheat
Authors: Sesiz Uğur , Alsaleh Ahmad , Bektas Harun , Topu Mustafa , Özkan Hakan 
Published: October 2023

AbstractGenotypes with longer coleoptiles can be sown in deep soil layers to reach the underground moisture needed for germination in dry areas. Developing new varieties with longer coleoptiles and shorter plant heights would be novel for wheat breeding and production. In this study, coleoptile lengths of a panel of durum wheat (Triticum turgidum ssp. durum) genotypes were determined, and 14,255 DArTseq (SNP and Silico‐DArT) markers were used to identify coleoptile length‐associated markers by genome‐wide association study (GWAS). A wide genetic variation was accounted for both coleoptile length and plant height. The genetic relationships between coleoptile length and plant height were evaluated using plant height values from five different environments. Two environmentally stable MTAs were identified, one for coleoptile length (QCol.su.4BS) and one for plant height (QPh.su.4BS). These MTAs were located on the short arm of chromosome 4B, with LOD scores up to 12.00 and 17.00, respectively. A relatively high LD (r2 = 0.71) was accounted for between QCol.su.4BS and QPh.su.4BS. The LD block intervals of the MTAs overlapped with some genes with roles in plant growth and development. The functions of plausible candidate genes tell us that QCol.su.4BS may be controlling coleoptile length, whereas QPh.su.4BS may be regulating plant height. The combination of the two loci would be desirable. In conclusion, this study sheds light on the genetic control of coleoptile length and its relationship with plant height in durum wheat.
Recent Discovery, Development, and Synthetic Applications of Formic Acid Salts in Photochemistry
Authors: Majhi Jadab , Molander Gary A. 
Published: October 2023

AbstractThe advancement of sustainable photoredox catalysis in synthetic organic chemistry has evolved immensely because of the development of versatile and cost‐effective reagents. In recent years, a substantial effort has been dedicated to exploring the utility of formic acid salts in various photochemical reactions. In this context, formates have demonstrated diverse capabilities, functioning as reductants, sources of carbonyl groups, and reagents for hydrogen atom transfer. Notably, the CO2⋅– radical anion derived from formate exhibits strong reductant properties for cleaving both C−X and C−O bonds. Moreover, these salts play a pivotal role in carboxylation reactions, further highlighting their significance in a variety of photochemical transformations. The ability of formates to serve as reductants, carbonyl sources, and hydrogen atom transfer reagents reveal exciting possibilities in synthetic organic chemistry. This minireview highlights an array of captivating discoveries, underscoring the crucial role of formates in diverse and distinctive photochemical methods, enabling access to a wide range of value‐added compounds.
Thiophene π‐bridge‐based second near‐infrared luminogens with aggregation‐induced emission for biomedical applications
Authors: Tan Yonghong , Sun Yan , Huang Weigeng , Zhu Dongxia , Yan Dingyuan , Wang Dong , Tang Ben Zhong 
Published: October 2023

AbstractIn the past 5 years, aggregation‐induced emission luminogens (AIEgens) with emission in the second near‐infrared (NIR‐II) optical window have aroused great interest in bioimaging and disease phototheranostics, benefiting from the merits of deep penetration depth, reduced light scatting, high spatial resolution, and minimal photodamage. To construct NIR‐II AIEgens, thiophene derivatives are frequently adopted as π‐bridge by virtue of their electron‐rich feature and good modifiability. Herein, we summarize the recent progress of NIR‐II AIEgens by employing thiophene derivatives as π‐bridge mainly compassing unsubstituted thiophene, alkyl thiophene, 3,4‐ethylenedioxythiophene, and benzo[c]thiophene, with a discussion on their structure–property relationships and biomedical applications. Finally, a brief conclusion and perspective on this fascinating area are offered.
Readability and content gaps in online epilepsy surgery materials as potential health literacy and shared‐decision‐making barriers
Authors: Seneviratne Namal U. , Ho Sophey Y. , Boro Alexis , Correa Daniel J. 
Published: October 2023

AbstractObjectiveEpilepsy surgery is an effective albeit underused treatment for refractory epilepsy, and online materials are vital to patient understanding of the complex process. Our goal is to analyze the readability and content inclusion of online patient health education materials designed for epilepsy surgery.MethodsA private browser setting was used on Google and Bing to identify the top 100 search results for the terms “epilepsy+surgery”. Scientific papers, insurance pages, pay‐wall access sites, and non‐text content were excluded. The website text was reformatted to exclude graphics, contact information, links, and headers. Readability metrics were calculated using an online tool. Text content was analyzed for inclusion of important concepts (pre‐surgical evaluation, complications, risks of continued seizures, types of surgery, complimentary diagrams/audiovisual material). Comparison of readability and content inclusion was performed as a function of organization types (epilepsy center, community health organization, pediatric‐specific) and location (region, country).ResultsBrowser search yielded 82 distinct websites with information regarding epilepsy surgery, with 98.7% of websites exceeding the recommended 6th‐grade reading level for health information. Epilepsy centers had significantly worse readability (Flesch–Kincaid Grade Level (FKGL) P < 0.01 and Flesch Reading Ease (FRE) P < 0.05). Content analysis showed that only 37% of websites discuss surgical side effects and only 23% mention the risks of continued seizures. Epilepsy centers were less likely to report information on surgical side effects (P < 0.001). UK‐based websites had better readability (FKGL P < 0.01 and FRE P < 0.01) and were more likely to discuss side effects (P = 0.01) compared to US‐based websites.SignificanceThe majority of online health content is overly complex and relatively incomplete in multiple key areas important to health literacy and understanding of surgical candidacy. Our findings suggest academic organizations, including level 4 epilepsy centers, need to simplify and broaden online education resources. More comprehensive, publicly accessible, and readable information may lead to better‐shared decision‐making.
Reconnecting with the Warrior Within: Australian Indigenous perspectives on the development of a social and emotional wellbeing program
Authors: Hodgkinson Luke , Bowman Sarah , Blunden Sarah 
Published: October 2023

AbstractIssue AddressedAustralian Indigenous youth are at high risk of developing mental health problems. Historical determinants and socioeconomic disadvantage continue to impact their social and emotional wellbeing (SEWB) and sense of identity. Previous literature suggests connecting to culture significantly impacts SEWB in Indigenous youth. Given the diversity of Indigenous culture, collaboration and consultation with specific cultural groups is required to develop appropriate and relevant psychological treatments for SEWB. The Warrior Within Program was developed to improve SEWB in Indigenous youth by assisting them to better understand their identity through participation in group‐based cultural activities. This research aimed to understand Central Queensland Indigenous Development staff perspectives around (1) the process of developing the program and (2) how group‐based cultural activities contributed to staff perceived improvements in SEWB of program participants.MethodsIn this qualitative study, semi‐structured individual interviews of 60–90 min were conducted with four Warrior Within Program staff of Central Queensland Indigenous Development. Transcripts were thematically analysed and the subthemes identified were categorised into main themes.ResultsThe process of developing the Warrior Within Program, cultural and Indigenous identity, reconnecting and knowledge emerged as the four main themes.ConclusionsThis study makes a unique and important contribution to the Australian Indigenous literature regarding the role and nature of culture in group‐based programs and the importance of collaborating with Indigenous groups to increase our understanding of their usefulness and efficacy. This study also helps to bridge the gap between Indigenous ways of knowing in program development and non‐Indigenous methods of evaluation.So What?Acknowledging Australian Indigenous methods and ways of knowing are essential to the development and delivery of culturally appropriate group problems for addressing the psychological needs of this population. The methods used in this study could be used by others seeking to legitimise cultural ways of knowing.
Recent advances in treatment technology of wastewater containing H‐acid: a mini‐review
Authors: Cao Yongjun , Hong Qing , Zhang Yuanjian 
Published: October 2023

AbstractH‐acid, a prevalent pollutant in dyeing wastewater, is primarily utilized in the pharmaceutical and textile industries. However, H‐acid treatment remains a challenge because of its high concentration, degradation resistance and poor biodegradability. This review examines the principles, characteristics, advantages and disadvantages of the most recently developed advanced practical H‐acid treatment technologies. Furthermore, this review analyzes the existing issues within these methods and explores potential future development trends. © 2023 Society of Chemical Industry.
Sirolimus for Pediatric Cervicofacial Lymphatic Malformation: A Systematic Review and Meta‐Analysis
Authors: Kamhieh Yasmine , Mitra Robin , Burnett Thomas , Jones Hugh , Roblin Graham , Hall Andrew 
Published: October 2023

ObjectiveThis study is a systematic review and meta‐analysis of the efficacy and safety of sirolimus in the management of pediatric cervicofacial lymphatic malformations (LMs).Data SourcesEMBASE, Medline, Scopus, and Cochrane databases were searched, along with the reference list of all included articles.Review MethodsThe study protocol was registered with PROSPERO and a systematic literature search strategy was designed and conducted with the aid of a medical librarian. All studies including case reports were included, with pooled analysis of raw data. A meta‐analysis was conducted of magnetic resonance imaging (MRI), clinical, and airway outcomes.ResultsThirteen case series and five individual case reports were included. Meta‐analysis showed 78% (95% CI 57%–94%) of 62 patients had a reduction in LM volume, on MRI criteria, by 20% or more, and 32% (95% CI 11%–57%) had a reduction of 50% or more. Further meta‐analysis showed 97% (95% CI 88%–100%) of 78 patients reported some clinical improvement on sirolimus. Sirolimus may be of particular value in management of airway LMs; out of 27 tracheostomy‐dependent patients, meta‐analysis showed 33% (95% CI 1%–78%) were decannulated after starting sirolimus. Individual patient meta‐analysis on 24 individuals showed a statistically significant better response to sirolimus when initiated under the age of 2 years.ConclusionThis review and meta‐analysis support the efficacy of sirolimus in pediatric LMs of the head, neck, and airway. A large multi‐center trial is needed to further explore its role and limitations. Laryngoscope, 134:2038–2047, 2024
Dynamic Crosslinking of Polyethylene by Hydrogen Bonding Grafted Motifs: A Molecular Dynamics Simulation Study
Authors: Hafezi Mohammad‐Javad , Sharif Farhad 
Published: October 2023

AbstractThe recyclability of polyethylene‐based is an important social and environmental issue. Dynamic crosslinking of polyethylene by multiple hydrogen bonding motifs provides an opportunity for complete recyclability. This approach is based on producing reversible covalent bonds in the crosslinking polyethylene networks to produce vitrimers. It is employed molecular dynamics simulation to study the effect of mole percent of randomly grafted 1‐(7‐oxo‐7,8‐dihydro‐1,8‐naphthyridin‐2‐yl) poly(ethylene‐co‐[2‐hydroxyethyl methacrylate])s (ODIN‐PEHEMAs), on thermal stability of the vitrimers. The crosslinking nature and dynamics of these grafted polyethylene chains are analyzed focusing on free volume, specific volume, radial distribution function, and mean squared displacement. The addition of hydrogen bonding units increased the free volumes, but the mole percent of side chains is not enough to affect the dynamics of the main chains in vicinity of the glass transition temperature. The simulation results show that for 1.67‐mole percent of randomly grafted ODIN‐PEHEMAs, the mean squared displacement, MSD, dramatically increases in vicinity of 312.5 K, which is in good agreement with the experimental results due to the physical cross‐linking breakage at room temperature. With increasing the mole percent of ODIN (4.33, 8.33, and 10.67 mole percent), the breakage of physical cross‐links shifted to higher temperatures.
The cell volume‐regulatory glycine transporter GLYT1 is activated following metallopeptidase‐mediated detachment of the oocyte from the zona pellucida
Authors: Ortman Chyna S. , Baltz Jay M. 
Published: October 2023

AbstractIndependent cell volume regulation is first acquired by the oocyte in two steps that occur during meiotic maturation: (1) activation of the glycine transporter GLYT1 (Slc6a9) that mediates the intracellular accumulation of glycine to provide osmotic support in the mature egg and early preimplantation embryo, and (2) release of the oocyte from the strong attachment to its rigid extracellular matrix shell, the zona pellucida (ZP). It was recently shown that oocyte‐ZP detachment requires metallopeptidase activity that is proposed to cleave transmembrane ZP proteins connecting the oocyte to the ZP. It is unknown, however, how GLYT1 is activated. We hypothesized that oocyte‐ZP detachment precedes and may be required for GLYT1 activation. In identically treated pools of oocytes, oocyte‐ZP detachment occurred ~20 min before GLYT1 activation. In individual oocytes, GLYT1 activity was detected only in those that were mostly or fully detached. Blocking detachment using previously validated small molecule metallopeptidase inhibitors partly suppressed GLYT1 activation. However, removal of the ZP did not accelerate GLYT1 activation. This indicates that oocyte‐ZP detachment or cleavage of transmembrane ZP proteins may be required for GLYT1 to become fully activated, or alternatively that metallopeptidase activity independently affects both detachment and GLYT1 activation.
Simultaneous detection and analysis of 11 nootropic compounds in 54 samples via liquid chromatography‐electrospray ionization‐tandem mass spectrometry and quadrupole time‐of‐flight mass spectrometry
Authors: Kim Nam Sook , Choi Hwan Seong , Shin Hyunil , Lee Ji Hyun , Kim Hyungil , Cho Sooyeul 
Published: October 2023

AbstractDietary supplements used for improving brain function and strengthening attention are increasingly popular. However, illegal dietary supplements containing unapproved drugs continue to be seized. Therefore, it is necessary to rapidly screen and identify adulterated compounds in dietary supplements for public safety. To develop the simultaneous analytical method, we selected 11 nootropic compounds and optimized the simultaneous liquid chromatography‐electrospray ionization‐tandem mass spectrometry and optimal conditions for liquid chromatography‐quadrupole time‐of‐flight mass spectrometry were proposed to determine the fragmentation patterns of each compound. The specificity, linearity, limit of detection, limit of quantification, method detection limit, method quantitation limit, precision, accuracy, matrix effect, and stability of this method were evaluated according to international validation guidelines. The validated methods were applied to 54 samples containing dietary supplements and seized samples. On screening 11 nootropic compounds were detected in four solid samples (tablet and powder). By comparing the product ion ratios with the standards and quantification, vinpocetine (6.52–34.2 mg/g) was found in three samples, and omberacetam (995.6 mg/g) in one sample. To re‐confirm the detected compounds, the fragmentation patterns were compared with those of the standards using liquid chromatography‐quadrupole time‐of‐flight mass spectrometry. The developed simultaneous analysis method can help maintain public health and safety.
Unilateral ends‐out gene targeting increases mistargeting through supporting extensive single‐strand assimilation
Authors: Mitrikeski Petar Tomev 
Published: October 2023

AbstractEnds‐out gene targeting enables the swapping of endogenous alleles with exogenous ones through homologous recombination which bears great implications both fundamental and applicable. To address the recombination mechanism(s) behind it, an experimental system was designed to distinguish between a possible (but rarely active) unilateral and the expected bilateral targeting in the yeast Saccharomyces cerevisiae in which the proportions of the two alternative genetic outcomes are conceived to mirror the probabilities of the two scenarios. The quantitative analysis showed that the bilateral targeting was expectedly predominant. However, an analogous comparative analysis on a different experimental set suggested a prevalence of unilateral targeting unveiling an uncertainty whether the extensively resected targeting modules only mimic unilateral invasion. Based on this, a comprehensive qualitative analysis was conducted revealing a single basic ends‐out gene targeting mechanism composed of two intertwined pathways differing in the way how the homologous invasion is initiated and/or the production of the intermediates is conducted. This study suggests that bilateral targeting lowers mistargeting plausibly by limiting strand assimilation, unlike unilateral targeting which may initiate extensive strand assimilation producing intermediates capable of supporting multiple genetic outcomes which leads to mistargeting. Some of these outcomes can also be produced by mimicking unilateral invasion.
Zur Multimethodik der Ethnographie der Streichensembles
Authors: Vollmer Theresa 
Published: October 2023

ZusammenfassungDie Ethnographie der Streichensembles verfolgt die Forschungsfrage: „Wie machen Klassisch ausgebildete Musiker:innen mit ihren Instrumenten und Noten in Streichensembles gemeinsam Musik und erleben sie dabei?“ (Kapitel III.E). Im vorliegenden Kapitel wird das Forschungsdesign und die Samplingstrategie der Studie dargelegt. Aus dem Forschungsstand und der erörterten Kritik wurden Hinweise für die methodologische Grundlegung des Untersuchungsdesigns erarbeitet (Kapitel III.D).