bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Symmetry Parameters in the E2 inner core of the pyruvate dehydrogenase complex
Authors: Kim Han-ul , Jeong Myeong Seon , An Mi Young , Park Yoon Ho , Park Sun Hee , Chung Sang J. , Yi Yoon-Sun , Jun Sangmi , Jung Hyun Suk 
Published: February 2024

Abstract

Recent advancements in cryo-electron microscopy (cryo-EM) have greatly facilitated the high-resolution structural determination of macromolecular complexes in their native states. The resultant deeper understanding of the structural mechanisms of protein complexes has improved our accessibility, not only to the field of structural biology but also to various biological phenomena. The structural analysis of proteins using cryo-EM, particularly single-particle analysis (SPA), entails the reconstruction of protein maps, which relies on the symmetry parameters of these proteins to obtain a more accurate map with the aid of image processing. In this paper, we present in the case of strong icosahedral symmetric complex, dihydrolipoyl acetyltransferase (E2) inner core complex of the pyruvate dehydrogenase complex (PDC) and obtain the reconstruction of identical 3D maps using five different symmetry parameters, including C1 without symmetric restraints to examine the impact of symmetry parameters for detailed structural analysis with a higher resolution. The results shows that the reconstructions using inappropriate symmetric parameters produce structurally identical 3D models even at the near-atomic level. Our findings convey a crucial message that should not be disregarded by researchers delving into SPA using relatively user-friendly and convenient image processing software for improved 3D model.
HDZ-740, a Potent FLT3 Inhibitor to Overcome FLT3 Mutations of Acute Myeloid Leukemia
Authors: Qiu Peiju , Yang Ting , Bi Shijie , Gao Yan , Wang Liping , Chu Yanyan , Yu Rilei , Yang Jinbo , Zhu Weiming , Chen Linmeng 
Published: February 2024

Abstract
Acute myeloid leukemia (AML) is a life-threatening cancer characterized by a five-year survival rate of less than 30%. A pivotal target for AML therapy is an activating mutation in Fms-like tyrosine kinase 3 (FLT3), known as FLT3-ITD, which has been identified as a critical factor in disease progression. Despite the clinical development of three FLT3 inhibitors, resistance to these drugs often emerges, leading to relapse in patients. In this context, we have developed a novel marine-derived compound, namely HDZ-740, which has demonstrated a specific ability to inhibit the proliferation of AML cells carrying the FLT3-ITD mutation. Furthermore, HDZ-740 markedly impeded the growth of BaF3 cells expressing FLT3-ITD-TKD mutations, including D835V, D835Y, Y842C, Y842H, F691L, N676K, as well as AML blasts from patients with FLT3-ITD mutations. HDZ-740 has also shown inhibitory effects in environments conducive to drug resistance, such as under the protection of stromal cells. In vivo, HDZ-740 effectively hindered the expansion of AML cells with the FLT3-ITD mutation. Collectively, these findings underscore the potential of HDZ-740 as an effective therapeutic agent for treating AML patients harboring diverse FLT3-ITD and FLT3-TKD mutations and highlight its capability to circumvent mechanisms of drug resistance.
The Effects of Microburst Varying Loads on Aircraft Using a Multi-Point Approach
Authors: Pourmoradi Ali , Sabzehparvar Mehdi 
Published: February 2024

Abstract
Microburst is an atmospheric phenomenon that poses a dangerous and unavoidable threat to flying aircraft during takeoff and landing. The dynamic response of the aircraft encountered to the microburst was studied. Research on the interaction between microburst and aircraft motion is needed to assess the effects of aerodynamic forces and momentum. Unlike recent studies using conventional integrated aerodynamic models, the multi-point loading approach allows microburst wind loading at any point on the wing and tail combination. In this method, a general reconstruction of aerodynamic forces and moments is calculated by microburst integration with different non-uniformly distributed loads functions on each surface of the aircraft. This algorithm solves the nonlinear equations of motion of a plane with six degrees of freedom and updates the plane's dynamic parameters as input to calculate time- and space-varying microburst effects for each element. The computational complexity of this method is therefore much reduced compared to CFD analysis and at the same time the details of the flight characteristics are taken into account without simplification in the simulation, which takes about 90 seconds of simulation time. We simulate and compare the results of a new and existing micro-race modeling approach. Comparing the two models shows significant differences in flight conditions such as aircraft flight path, angle of attack and angular velocity.
Effects of Lupeol On Experimental Testicular Ischemia/Reperfusion Damage in Rats
Authors: Azzam Abdurrahman , Karabulut Ramazan , Kaya Cem , Eryilmaz Sibel , Kapisiz Alparslan , Turkyilmaz Zafer , Inan Mehmet Arda , Aydin Gizem Yaz , Sonmez Kaan 
Published: February 2024

Abstract
Objective Infertility and organ loss are possible outcomes of testicular torsion, a urological emergency. We sought to demonstrate the impact of lupeol on testicular ischemia reperfusion damage in this investigation.Methods 30 adult male Spraque Dawley rats were randomized and divided as Control(C), Lupeol(L), Ischemia(I), Treatment 1(T1) and Treatment 2(T2) groups. In the study groups, detorsion was applied to the left testicles by creating 720 degree testicular torsion for 2 hours. While 100 mg/kg Lupeol was injected intraperitoneally in the T1 and T2 groups 30 min. before and immediately after testicular detorsion. At the sixth hour, samples of blood and testicular tissue were obtained from every rat. Measurements were taken of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) tissue glutathione (GSH), malondialdehyde (MDA), and caspase 3. Histopathological analysis was used to evaluate the Johnsen Tubular Biopsy Score (JTBS).Results It was observed that Caspase 3, MDA, IL-6 and TNF-ɑ values, which increased in Group I compared to the Group C, decreased more significantly in both treatment groups and especially in the GroupT1 group (p = 0.001, only p = 0.768 for TNF-ɑ). GSH levels was decreased in Group I, increased more significantly in both treatment groups and especially in the GroupT1 group. JTBS improvement was observed in both treatment groups (p = 0.001).Conclusion In this study, where Lupeol was used for the first time in an experimental testicular torsion model, its antioxidant, anti-inflammatory and anti-apoptotic effects, as well as its histopathological damage-reducing and protective effects, were demonstrated.
Blow up Analysis of Constraint Minimizers for a Class of Elliptic Equations with Bi-nonlocal Terms
Authors: Zhu Xincai , Zhu Yajie 
Published: February 2024

Abstract
This paper is devoted to studying a class of elliptic equations with bi-nonlocal terms. Using the methods of constrained variation and energy estimation, we analyze the existence, non-existence and blow-up behavior of constraint minimizers for the related minimization problem. Our work extend and enrich the results of [7,40], which mainly involve bi-nonlocal problems.
2020 MSC: 32J20; 35J60; 35Q40; 46N50
Exploring stress corrosion cracking in 2205 duplex stainless steel across varied stress thresholds
Authors: Zhao Shuai , Wen Shaomu , Guo Xiaoxiong , Qin Lin , Lin Dong , Liao Kexi 
Published: February 2024

Abstract
Reboilers are pivotal in the process of condensate oil stabilization, playing a significant role in reducing the vapor pressure to ensure product stability. The operational milieu of reboiler tube bundles is marked by extremities—high temperatures, elevated salinity, and the presence of dissolved oxygen—rendering them vulnerable to stress corrosion cracking. Such conditions can precipitate untimely degradation and disrupt production schedules. Addressing this, our research employed electrochemical noise measurement techniques to perform a statistical examination of the morphological characteristics of noise peaks, alongside time and frequency domain analyses for 2205 Duplex Stainless Steel(DSS), under an array of stress levels, ranging from 60%σs to 90%σs. Complementary Scanning Electron Microscopy analysis was utilized to discern microscopic changes pre- and post-corrosion exposure. Findings have demonstrated pronounced localized corrosion at each measured stress level, with localized corrosion index values spanning from 0.4290 to 0.9993. The presence of chloride ions was found to penetrate the passive film, selectively targeting the ferrite phase for pitting. Furthermore, the confluence of mechanical stress and corrosive elements facilitated the nucleation of crack tips, with oxygen and chloride ions synergistically escalating crack propagation. Our study concludes that the SCC of 2205 DSS follows a dual path: anodic dissolution alongside hydrogen embrittlement, culminating in surface pitting and intergranular cracking.
Investigation of the heat resistance of a metal-glass composite material based on iron
Authors: Getmanovskiy Yuriy , Maltsev Ilya 
Published: February 2024

Abstract
The article presents a study aimed at obtaining a composite antifriction material. The structure and properties of a metal-glass material based on iron, represented by VK-1 powder, were researched. The relationship between the content of the reinforcing glass filler, represented by the shards of container glass, and the heat resistance of the resulting composite was revealed. It was revealed that with an increase in the content of glass filler up to 15% of the volume, the heat resistance increases.
Potential Assessment of Chrysanthemum Cultivars as Source of Natural antioxidants and Bioactive Compounds
Authors: Patil Savita A. , Kulkarni Asmita J. , Jadhav Pritam R. , Yadav Rahul S. , Pagariya Madhuri C. , Saha Tarak Nath , Shabeer TP Ahammed , Sharma Ajay K. , Prasad K.V. , Kawar Prashant G. 
Published: February 2024

Abstract
Chrysanthemum blossoms, renowned for their aesthetic appeal, have gained recognition as potential contributors to nutraceuticals, cosmeceuticals, and pharmaceuticals, thereby impacting human health. Phytochemical composition and antioxidative properties of 22 distinct Indian chrysanthemum cultivars was studied. The cultivars viz., Bidhan Protima, Mauve Sarah, Silk Brocate, Diamond Jubilee, and Mahatma Gandhi displayed remarkable levels of phenolic compounds, tannins, saponins, and carotenoids, emphasizing their superior antioxidant capacity. This study also presents the first quantitative determination of total saponin content in Chrysanthemum morifolium. Hierarchical analysis categorized cultivars into three groups based on their phytochemical profiles. Correlation analysis underscored the importance of anthocyanins and phenolic compounds in antioxidative attributes. Additionally, variations in carotenoid content unveiled astaxanthin, zeaxanthin, mutatochrome, canthaxanthin, neoxanthin, violaxanthin, and auroxanthin as potential biomarkers in differentiating cultivars. The research elucidates the rich phytochemical diversity of Indian chrysanthemum cultivars, positioning them as invaluable resources for nutraceuticals and pharmaceuticals, with potential benefits for human well-being.
Impact of the Behavior Modulated LEACH System
Authors: Korteby Amine , Gal Zoltan 
Published: February 2024

Abstract
Wireless Sensor Networks (WSNs) have made significant strides in recent years owing to their growth in terms of equipment and cost reduction. Several services have been designed, based on the application and network architecture. The LEACH (Low Energy Adaptive Clustering Hierarchy) mechanism is one of the most considerable energy protecting solutions in WSN environments. This hierarchical protocol aggregates and forwards data from cluster members to a fixed Sink node using the cluster head feature of the nodes. We developed a new set of routing mechanisms called CB-LEACH by introducing movement possibility to the Sink node and balancing the cluster head election decision taking into consideration not just the distances between the nodes but the residual energy of the potential cluster head candidates, as well. In this paper, we modulate the balance factor of the cluster head election to conform to different rules and we analyzed the behaviour of the new system and its most important features.
Irrigation Water productivity in Rice Crop through Alternate Wetting and Drying method
Authors: Gautam Anand , Kendra Krishi Vigyan 
Published: February 2024

Abstract
The demonstrations on alternate wetting and drying (AWD) in rice crop were conducted by KVK Ferozepur, Punjab during Kharif 2019-21 at 25 locations in 5villages of district. The selected study locale was characterized by well drained sandy loam with medium soil fertility status. The three plots of 0.4 ha size each was selected for the two treatments i.e. alternate wetting and drying and continuous submergence (farmer practice) at each of 25 locations. The rice grain yields increased by 1.18 per cent under AWD compared to the continuous submergence (71.4 q/ha). The irrigation water productivity (IWP) was higher by 18.36 per cent under AWD compared to that in continuous submergence. Ricecrop under AWD required 30 cm smaller amount of irrigation water during its whole growing season compared to the continuous submergence. The AWD technique holds great promise as water-saving technology that can help to address water scarcity in the rice growing areas of food basket bowl of India. Therefore, the AWD method could enhance yield and save irrigation water by 18–20 percent in rice crop.
Nonlinear relationship between platelet count and 30-day in-hospital mortality in ICU acute respiratory failure patients: a multicenter retrospective cohort study
Authors: Zhou Pan , Guo Qin-qin , Wang Fang-xi , Zhou Li , Hu Hao-fei , Deng Zhe 
Published: February 2024

Abstract

Background
Limited evidence exists regarding the link between platelet count and 30-day in-hospital mortality in acute respiratory failure (ARF) patients. Thus, this study aims to investigate this association among ICU patients experiencing acute respiratory failure.
Methods
We conducted a retrospective cohort study across multiple centers, utilizing data from the US eICU-CRD v2.0 database covering 22,262 patients with ARF in the ICU from 2014 to 2015. Our aim was to investigate the correlation between platelet count and 30-day in-hospital mortality using binary logistic regression, subgroup analyses, and smooth curve fitting.
Results
The 30-day in-hospital mortality rate was 19.73% (4,393 out of 22,262), with a median platelet count of 213×109/L. After adjusting for covariates, our analysis revealed an inverse association between platelet count and 30-day in-hospital mortality (OR = 0.99, 95% CI: 0.99, 0.99). Subgroup analyses supported the robustness of these findings. Furthermore, a nonlinear relationship was identified between platelet count and 30-day in-hospital mortality, with the inflection point at 120×109/L. Below the inflection point, the effect size (OR) was 0.89 (0.87, 0.91), indicating a significant association. However, beyond this point, the relationship was not statistically significant.
Conclusion
This study establishes a clear negative association between platelet count and 30-day in-hospital mortality among ICU patients with ARF. Furthermore, we identified a nonlinear relationship with a saturation effect, indicating that maintaining the platelet count around 120×109/L can reduce 30-day in-hospital mortality in this patient group.
Ameliorative role of β-Caryophyllene on antioxidant biomarkers in Paroxetine induced erectile dysfunctional rats
Authors: Olopade Elijah Oluwatosin , Adefegha Stephen Adeniyi , Oboh Ganiyu , Adepoju Ayodeji Emmanuel , Fakayode Aderonke Elizabeth , Alao Jude Oluwapelumi 
Published: February 2024

Abstract
Erectile dysfunction is a leading cause of male infertility linked to oxidative stress. This study aimed to assess B-Caryophyllene (BCP) as an antioxidant on penile tissue in Paroxetine-induced rats. In vitro tests evaluated BCP's antioxidant properties, including ferric reduction, DPPH, ABTS, and hydroxyl radical scavenging, plus TBARs assays. Forty-five rats were divided into nine groups: Normal control (NC), BCP (10 mg/kg), BCP (20 mg/kg), Sildenafil citrate (SC) (20mg/kg), BCP + SC (20 mg/kg), Paroxetine (PD) (20 mg/kg), PD + BCP (10mg/kg), PD + BCP (20mg/kg), and PD + SC (20 mg/kg). PD was orally administered for seven days. BCP and SC treatments occurred from day 8 to 14. Enzyme activities (S.O.D., Catalase, G.S.T., and GPx) and TBARS were measured spectrophotometrically. PD caused erectile dysfunction, reducing mount latency (ML) and intromission latency (I.L.). BCP concentration-dependently enhanced reducing power, ABTS, OH scavenging, and % DPPH inhibition, significantly lowering %TBARS compared to sildenafil citrate. IC50 values for OH radical, DPPH, and Iron (II) ion chelation were 10.98 µg/mL, 59.14 µg/mL, and 17.36 µg/mL. In vivo, BCP significantly (p < 0.001) increased S.O.D., Catalase, and GPx activities. G.S.T. activity significantly (p < 0.01) increased with BCP (20 mg/kg). BCP (20 mg/kg) significantly (p < 0.001) lowered TBARS more effectively than SC. BCP, especially at 20 mg/kg, displayed potent antioxidative effects on penile tissue in Paroxetine-induced rats.
Analisis Pencapaian Implementasi Permakultur di SMK Suwakul Ungaran Menggunakan Balanced Scorecard
Authors: Handayani Susana Ayu , Wiyatiningsih  
Published: February 2024

Title: Analysis of Achievement for Permaculture Implementation at Suwakul Vocational High School Ungaran Using Balanced Scorecard
The agricultural vocational school program hopes to increase human resources capable of cultivating land, managing horticultural crops, and producing agricultural products. Suwakul Ungaran Vocational School is one of the vocational schools in Semarang Regency that applies permaculture in its learning process. The permaculture principles applied at this school are capturing and storing energy, getting harvests, using and respecting resources, zero waste, and respecting diversity. Based on this background, this research focuses on learning outcomes through implementing permaculture with a sustainable agricultural system that includes the development of land processing based on natural ecosystems. The research aims to determine the ability of students at school to produce food and horticultural crops. This research applies a qualitative descriptive method to describe the results of permaculture implementation using Balanced Scorecard analysis, an evaluation strategy with four perspectives in improving an organization's goals. The research results show that learning through the implementation of permaculture at this Vocational School can improve students' abilities at school, as seen from fulfilling the perspective of the Balanced Scorecard. The study's results will be helpful for schools as a learning tool to improve students' abilities in producing agricultural products through the implementation of permaculture.
A Christian Philosophy Grounded in the Experience of Truth
Authors: Lentija Zyra F. 
Published: February 2024

This paper focuses on a Christian philosophy grounded in the experience of truth. To better understand this, it will explore: (1) the kind of philosophical approach that provides a space for people to preoccupy themselves with truth and draws them to further probe into the fundamental questions; (2) a return to the basics: philosophy as love of wisdom and for love of wisdom is personal, an experiential journey; (3) finally, a vision of Christian philosophy that is not purely theoretical but teaches one how to incarnate every truth and virtue. Christian philosophy provides us with an experience in, with, and of the truth in terms of understanding and developing certain traits and virtues such as prudence, justice, fortitude, and temperance. The shaping and molding of these good habits within each person are important in maintaining a Christian worldview to keep one grounded while being immersed in the world and its realities, allowing the Christian to become a reality within oneself and for others.
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Received: 20/03/2023. Reviewed: 18/04/2023. Accepted: 24/04/2023.
A Simple Score for Predicting Paroxysmal Atrial Fibrillation in Patients
with Embolic Stroke of Undetermined Source in a Tunisian Cohort Study
Authors: Ben Amor Sana , Achour Assil , Elhraiech Aymen , Jarrar Emna , Ghali Hela , Ameur Ons Ben , Amara Nesrine , Hassine Anis , Saied Houyem , Neffati Eleys , Smadja Didier 
Published: February 2024

Background:
The annualized recurrent stroke rate in patients with Embolic Stroke of
Undetermined Source (ESUS) under antiplatelet therapy is around 4.5%. Only a fraction of these
patients will develop atrial fibrillation (FA), to which a stroke can be attributed retrospectively.
The challenge is to identify patients at risk of occult AF during follow-up.

Objectives:
This work aims to determine clinical factors and electrocardiographic and ultrasound
parameters that can predict occult AF in patients with ESUS and build a simple predictive score
applicable worldwide.

Methods:
This is a single-center, registry-based retrospective study conducted at the stroke unit
of Sahloul University Hospital, Sousse, Tunisia, between January 2016 and December 2020.
Consecutive patients meeting ESUS criteria were monitored for a minimum of one year, with a
standardized follow-up consisting of outpatient visits, including ECG every three months and a
new 24-hour Holter monitoring in case of palpitations. We performed multivariate stepwise regression
to identify predictors of new paroxysmal AF among initial clinical, electrocardiographic
(ECG and 24-hour Holter monitoring) and echocardiographic parameters. The coefficient of
each independent covariate of the fitted multivariable model was used to generate an integerbased
point-scoring system.

Results:
Three hundred patients met the criteria for ESUS. Among them, 42 (14%) patients
showed at least one episode of paroxysmal AF during a median follow-up of two years. In univariate
analysis, age, gender, coronary artery disease, history of ischemic stroke, higher NIHSS
at admission and lower NIHSS at discharge, abnormal P-wave axis, prolonged P-wave duration,
premature atrial contractions (PAC) frequency of more than 500/24 hours, and left atrial (LA)
mean area of more than 20 cm2 were associated with the risk of occurrence of paroxysmal AF.
We proposed an AF predictive score based on (1.771 x NIHSS score at admission) + (10.015 x
P-wave dispersion; coded 1 if yes and 0 if no) + (9.841x PAC class; coded 1 if ≥500 and 0 if no)
+ (9.828x LA class surface; coded 1 if ≥20 and 0 if no) + (0.548xNIHSS score at discharge) +
0.004. A score of ≥33 had a sensitivity of 76% and a specificity of 93%.

Conclusion:
In this cohort of patients with ESUS, NIHSS at both admission and discharge, Pwave
dispersion, PAC≥500/24h on a 24-hour Holter monitoring, and LA surface area≥20 cm2
provide a simple AF predictive score with very reasonable sensitivity and specificity and is applicable
almost worldwide. An external validation of this score is ongoing.