bluuebunny/crossref_metadata_2025_split huggingface dataset:
3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: an open-source catalogue of findings
Authors: Schendel Diana , Ejlskov Linda , Overgaard Morten , Jinwala Zeal , Kim Viktor , Parner Erik , Kalkbrenner Amy E , Acosta Christine Ladd , Fallin M Danielle , Xie Sherlly , Mortensen Preben Bo , Lee Brian K 
Published: November 2023

AbstractThe relatively few conditions and family members investigated in autism family health history limits etiologic understanding. For more comprehensive understanding and hypothesis-generation we produced an open- source catalogue of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980-2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6,462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are catalogued in interactive heat maps and down- loadable data files:https://ncrr-au.shinyapps.io/asd-riskatlas/and interactive graphic summaries:https://public.tableau.com/views/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and non-genetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity.Lay summaryWe calculated the likelihood that a person will be diagnosed with autism if they had a specific family member (e.g, a parent, sibling, grandparent) with a specific mental, neurologic, cardiometabolic, birth defect, asthma, allergy, or autoimmune condition - over 6,000 separate estimates based on 26,840 autistic persons. Results are catalogued in interactive figures and down-loadable data files:https://ncrr-au.shinyapps.io/asd-riskatlas/and interactive graphic summaries:https://public.tableau.com/views/ASDPlots_16918786403110/e-Figure5. Thestudy of autism family health history - which varies widely by condition, family member type, sex of the family member, side of the family, sex of the index person, intellectual disability status - may advance understanding of factors underlying neurodiversity.
Early Progressive Peripheral Airway Dysfunction after Allogeneic Haematopoietic Stem Cell Transplantation is associated with chronic Graft vs Host disease not BOS-0p
Authors: Htun Christopher , Schoeffel Robin E , Rutting Sandra , Huvanandana Jacqueline , Thamrin Cindy , Pope Alun , Phillips Craig L , Greenwood Matthew , Pechey Victoria , King Gregory G , Robinson Paul D 
Published: November 2023

AbstractBackgroundCurrent spirometric-based criteria for diagnosis of bronchiolitis obliterans syndrome (BOS) may miss early peripheral airway disease associate with disease onset. Multiple breath washout (MBW) and oscillometry offer improved sensitivity, but longitudinal changes occurring in allogeneic haematopoietic stem cell transplantation (HSCT) are unknown.ObjectiveIn this longitudinal study of HSCT survivors, we investigated changes in nitrogen-based MBW, oscillometry and conventional lung function, from baseline (pre-transplant), over 36-months, and associations with BOS Stage 0p, a spirometry-defined risk classification for potential later BOS development, and chronic graft-vs-host disease (cGVHD).Study DesignLongitudinal observational study of allogeneic HSCT recipients from a single adult centre. All participants underwent spirometry, plethysmography, gas transfer capacity (DLCO), oscillometry and MBW at each study visit. Tests were performed pre-HSCT and 3 monthly thereafter over 36 months.Results64 of 69 recipients recruited were included in the final analysis. Across the entire cohort, deterioration in acinar ventilation inhomogeneity (Sacin) occurred as early as 90 days post-HSCT (0.224 z score change/month, p<0.001), prior to any significant change in spirometry or oscillometry. Progressive deteriorations in Sacinwere associated with cGVHD status and grade but not BOS-0p status.ConclusionsEarly progressive peripheral airway dysfunction occurred following HSCT and was best detected by Sacinfrom MBW. Distal acinar ventilation inhomogeneity (Sacin) deteriorated at an earlier stage than spirometry. Longitudinal deteriorations in Sacinwere related to cGVHD, and independent of early changes in spirometry parameters. These findings suggest an important role of the lung in cGVHD and provide important evidence to support future studies examining the prognostic utility of MBW in long-term monitoring of HSCT patients to provide an early effective signal of BOS.HighlightsThe evolution of peripheral airway function abnormality assessed using Multiple Breath Washout (MBW) and oscillometry following allogeneic HSCT is unknown.Progressive abnormality is established early following HSCT and occurred in those who developed chronic graft versus host disease (cGHVD) in other organ systems.This highlights the risk of peripheral airway dysfunction in those affected by cGVHD.MBW to monitor post-HSCT subjects provides additional insight to that provided by BOS-0p criteria which did not show the same relationship to cGHVD.These findings identify a potential window for earlier targeted treatment to improve long term outcomes.
Ggnbp2regulates synaptic development and autophagy in motor neurons
Authors: Kerwin Sarah K. , Carrodus Nissa , Kewin Amber , Lin Tian , Qian Xiaoyu , McRae Allan F. , Yang Jian , Collins Brett M. , Wray Naomi R. , Garton Fleur C. , Millard S. Sean 
Published: November 2023

AbstractGenome-wide association studies (GWAS) have identified numerous candidate ALS risk variants, but their cellular functions are often unknown. Recent studies have identified a variant ofGGNBP2that results in increased expression. To better understand how this gene might contribute to disease, we investigated the function ofDrosophila Ggnbp2 (dGgnbp2)in motor neurons. Loss of function studies showed thatdGgnbp2is required for motor neuron synaptic development. A human transgene completely rescued these phenotypes indicating that the gene is functionally conserved between humans and flies. Overexpression ofdGgnbp2caused severe locomotor defects in adult flies, consistent with ALS pathology. At the cellular level,dGgnbp2regulated autophagy, a process commonly defective in ALS. Both overexpression and removal ofdGgnbp2reduced levels of the phosphorylated lipid, PI(3)P, an essential component of autophagosomes. Our study provides strong evidence thatGgnbp2functions in motor neurons to regulate a cellular process commonly defective in ALS.TeaserThis study investigated the function of the ALS risk variantGGNBP2, in flies, and showed that it regulates autophagy in motor neurons.
Responding to incivility: exploring revenge and incivility climate
Authors: Daniels Shanna R. , Simmons Aneika L. 
Published: November 2023

PurposeThe purpose of this study was to test a mediated-moderated model with revenge cognitions as a coping mechanism through which experienced incivility leads to perpetrated incivility. The authors further explore the role of organizational climate for incivility.Design/methodology/approachTwo studies were tested utilizing ordinary least squares (OLS) regression and Hayes (2017) process for mediation and moderation. Study 1 was completed by 321 employees, and study 2 was completed by 197 employees each from across many occupations.FindingsStudy 1 results indicate support for a positive relationship between experienced incivility and perpetrated incivility. Study 2 results indicate support for a mediated-moderated relationship where experienced incivility was indirectly associated with incivility perpetration through revenge, and the perception of an incivility climate moderated this relationship.Originality/valueThis is the first study to examine revenge as an explanatory mechanism for responding to incivility. It addresses concerns about revenge cognitions to experiencing incivility and the role climate perceptions play in shaping whether an individual will reciprocate with an uncivil act. The authors’ results accentuate the need for organizations to decrease or eradicate incivility so that their employees can evade the associated adverse outcomes.
Mapping the landscape of female entrepreneurship in Africa: trends, networks and hot topic through text mining techniques
Authors: Wedajo Abel Dula , Khan Shagufta Tariq , Bhat Mohd Abass , Zahran Al Balushi Yousuf Mohamed 
Published: November 2023

PurposeThe study examines the characteristics and development trends of female entrepreneurship publications, cooperation networks between countries, journals and individuals, intellectual structure of female entrepreneurship studies in Africa and hot research topics. Future comparative studies in different contexts and interdisciplinary collaboration can enrich the understanding about female entrepreneurship research.Design/methodology/approachThe authors used text mining to analyze 130 peer-reviewed articles published from 1975 to 2022 for keywords and classify them into eight main classes: (1) Paradoxical space and informality, (2) work–family conflict, (3) women's entrepreneurial identity and networking, (4) rural women's entrepreneurial activities in the agricultural sector, (5) religious belief and women's entrepreneurial practice, (6) financial trap and environmental challenges, (7) women's entrepreneurial intentions and capacity building and (8) women in cultural entrepreneurship.FindingsFemale entrepreneurship publications develop significantly. Since 1975, African female entrepreneurship study has grown. Results show 130 publications from 1975 to 2023, with two papers published yearly in 2006–2011 and 23 in 2023, indicating growing interest. Paradoxical space and informality, work–family conflict, women's entrepreneurial identity and networking, religious belief and practice, financial trap and environmental challenges and entrepreneurial intentions and capacity building were hot topics identified by topic modeling analysis.Practical implicationsFemale entrepreneurs have looser intellectual networks. Nation, organization and researcher communication is inadequate. Collaborating researchers from different universities and countries may develop the field.Originality/valueThis study is more data-driven and less biased than earlier reviews because it is based on thousands of citation data rather than a small number of papers pre-selected by the researchers. Displaying the field's structure and evolution enhances previous reviews.
Crowding between urban planning and environmental psychology: guidelines for bridging the gap
Authors: El-Didy Mai Hossam , Hassan Ghada Farouk , Afifi Samy , Ismail Ayat 
Published: November 2023

PurposeCrowded urban regions pose a complex urban challenge that can adversely affect urban residents, encompassing aspects like mental and physical well-being, overall livability and quality of life. The complexity in determining the factors influencing the crowding perception, which encompass subjective and situational psychological factors alongside physical and environmental attributes, imparts ambiguity to planners' approach. This study aims to unravel the intricate interplay between crowding and the physical attributes inherent in the built environment.Design/methodology/approachThis literature review analyses theories linking urban planning and environmental psychology to uncover gaps in the relationship between urban design principles and residents' perceptions of crowding. It also explores influential variables affecting crowding perception and diverse methodologies across contexts.FindingsThe study built upon a broad literature review which is expected to summarise and classify the variables of urban planning components and approaches according to their impacts on the psychological perception of crowding. Furthermore, highlighting a number of recommendations that can be considered a guide for planners and urban designers to enhance the urban experience and reduce the perception of crowding.Originality/valueThis study seeks to improve the overall experience of crowding in densely populated urban areas. It accomplishes this by identifying influential factors and comprehending the associated outcomes in such contexts. Furthermore, it bridges perspectives from various fields to examine relevant policies and strategies to mitigate crowding consequences.
Industry‐sponsored meal payments are associated with prescriptions and Medicare expenditures on brand‐name colchicine in the United States
Authors: Murayama Anju 
Published: November 2023

AbstractAimTo investigate the association between industry‐sponsored meal payments and the prescribing patterns of brand‐name colchicines, namely Colcrys and Mitigare, among Medicare beneficiaries in the United States from 2014 to 2021.MethodsThis cross‐sectional study utilized data from the Open Payments Database and Medicare Part D covering the years 2014 to 2021. The study included 54 836 physicians who submitted more than 10 colchicine claims. Exposure was defined as the receipt of one or more industry‐sponsored meals from the manufacturers of Colcrys or Mitigare. The primary outcomes included the likelihood of prescribing Colcrys and Mitigare, as well as the associated number of claims and Medicare expenditures.ResultsAmong 54 836 eligible physicians, 44.9% received meal payments from the Colcrys manufacturer, and 8.0% from the Mitigare manufacturer, over the eight‐year study period. The average meal payment value was $14.9 for Colcrys and $15.1 for Mitigare. The receipt of meal payments was significantly associated with an increased likelihood of prescribing Colcrys (odds ratio: 1.24 [95% CI: 1.21–1.27], p < .001) and Mitigare (odds ratio: 3.54 [95% CI: 2.98–4.20], p < .001). Each additional meal payment corresponded with a significant increase in Medicare expenditures: $55.4 (95% CI: $48.3–$62.5, p < .001) for Colcrys and $153.7 (95% CI: $17.7–$289.6, p = .03) for Mitigare. These associations remained consistent across different specialties and genders.ConclusionThis study reveals that receipt of meal payments from manufacturers of brand‐name colchicine was significantly associated with an increased rate of prescriptions for these brand‐name drugs, leading to higher Medicare expenditures in the United States.
Dissociation of drug and negative emotional cue induced attentional bias in individuals with methamphetamine‐use disorder
Authors: He Meiheng , Wang Lili , Zhu Dong , Xu Ding , Zhu Xiangru , Yang Suyong 
Published: November 2023

AbstractBackground and ObjectivesAlthough both drugs and negative emotions can trigger drug craving or relapse in individuals with methamphetamine‐use disorder (MUD), it remains unclear whether individuals with MUD have attentional biases toward both drug and negative emotional cues and whether this bias involves attention orientation or difficulty in attention disengagement. This study aimed to measure different components of attentional bias toward drug‐related and negative emotional cues in individuals with MUD.MethodsTwo dot‐probe tasks were used to investigate attentional bias toward drug (drug task) and negative emotional cues (emotion task) in individuals with MUD. Forty‐three males with MUD (average age of 43.44 ± 11.91 years, average drug‐use duration of 11.35 ± 8.39 years) participated in the study voluntarily.ResultsThere was a significant interaction between the task type and location (p = .01). Specifically, for drug cues, participants showed significant difficulty in attention disengagement toward drug cues (p = .01); however, no attention orientation (p = .46). For negative emotional cues, neither significant attention orientation (p = .07) nor significant difficulty in attention disengagement (p = .50) was found.Conclusions and Scientific SignificanceAttentional bias in individuals with MUD was highly selective for drug cues; thus, difficulty in attention disengagement from drug cues can be considered a potential mediating mechanism for attentional bias modification interventions for individuals with MUD. This study served to generate hypotheses or suggest future experiments on interventions for individuals with MUD.
Is testosterone deficiency a predictive factor for recurrence of urethral stricture?
Authors: Özsoy Emrah , Kutluhan Musab Ali , Tokuç Emre , Kayar Rıdvan , Demir Samet , Akyüz Mehmet , Öztürk Metin İshak 
Published: November 2023

AbstractBackgroundTestosterone plays a vital role in maintaining tissue homeostasis, and testosterone deficiency may potentially influence the likelihood of urethral stricture recurrence.ObjectivesTo evaluate the prognostic value of testosterone levels in the recurrence after direct visual internal urethrotomy in primary short segment bulbar urethral strictures and its clinical reflections.Materials and methodsA total of 723 patients who underwent direct vision internal urethrotomy between January 2000 and October 2022 were retrospectively analyzed. After implying exclusion criteria, 116 patients with available data were enrolled. Patients were divided into two groups as recurrence and no recurrence. Age, stricture length, etiology, time of recurrence, diagnosis of previous diabetes mellitus, hypertension, smoking, body mass index, and total testosterone levels were recorded. Free testosterone and bioavailable testosterone values were calculated using total testosterone, albumin, and sex hormone binding globulin values. Hypogonadism was considered as a total testosterone level less than 300 ng/dL. Demographic characteristics and total testosterone, free testosterone, and bioavailable testosterone levels were compared between the two groups for statistical significance. The recurrence rates of patients with and without hypogonadism were compared.ResultsRecurrence was observed in 41.4% of the cases (n = 48). There was no statistically significant difference between the groups in terms of age, body mass index values, diabetes mellitus, hypertension, smoking status, presence of hypogonadism, and etiology (p = 0.745, 0.863, 0.621, 0.622, 0.168, 0.051, and 0.232). In terms of total testosterone levels and bioavailable testosterone levels, the recurrence group had significantly lower values (p = 0.018 and 0.04). There was no significant difference between the two groups in terms of stricture length (p = 0.071). Sixteen of 28 patients with hypogonadism had recurrence, whereas 32 of 88 patients without hypogonadism had recurrence (p = 0.051).DiscussionTestosterone levels have potential to predict recurrence in primary short‐segment bulbar urethral strictures. This study represents the inaugural analysis of the impact of testosterone deficiency on recurrence within the cohort of patients with primary short‐segment bulbar urethral strictures.ConclusionTestosterone levels and ratios may serve as predictive factors for identifying recurrent cases in primary short‐segment bulbar strictures. For patients at a higher risk of recurrence, urethroplasty may be considered as an initial treatment option, even in cases of primary and short‐segment strictures.
The effects of bupropion alone and combined with naltrexone on blood pressure and CRP concentration: A systematic review and meta‐regression analysis of randomized controlled trials
Authors: Jiang Qidong , Velu Periyannan , Sohouli Mohammad Hassan , Ziamanesh Fateme , Shojaie Shima , Fatahi Somaye , Li Qin 
Published: November 2023

AbstractBackgroundConsidering the conflicting effects of bupropion on parameters related to cardiovascular system including blood pressure and inflammation, in this meta‐analysis study, we investigated the effects of this drug alone or in combination with naltrexone on systolic (SBP) and diastolic blood pressure (DBP) and C‐reactive protein (CRP).MethodsScopus, PubMed/Medline, Web of Science and Embase databases were searched using standard keywords to identify all controlled trials investigating effects of bupropion alone and combined with naltrexone on the BP and CRP. Pooled weighted mean difference and 95% confidence intervals (CIs) were achieved by random‐effects model analysis for the best estimation of outcomes.ResultsThe pooled findings showed that that bupropion alone or in combination with naltrexone would significantly increase SBP (weighted mean difference (WMD): 1.34 mmHg, 95% CI: 0.38–2.29) and DBP (WMD: 0.93 mmHg, 95% CI 0.88–0.99) as well as decrease CRP (WMD: −0.89 mg/L, 95% CI −1.09 to −0.70). The findings of the subgroup also show the greater effect of bupropion on blood pressure (SBP and DBP) increase in a dose greater than 360 mg and a duration of intervention less equal to 26 weeks. In addition, the subgroup analysis showed that changes in SBP after receiving bupropion together with naltrexone were more compared to bupropion alone.ConclusionsThe addition of combination therapies such as bupropion and naltrexone can significantly improve CRP levels. However, its effect on blood pressure requires proper management of this drug.