bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer
Authors: Fujino Shiki , Miyoshi Norikatsu , Ito Aya , Hayashi Rie , Yasui Masayoshi , Matsuda Chu , Ohue Masayuki , Horie Masafumi , Yachida Shinichi , Koseki Jun , Shimamura Teppei , Hata Tsuyoshi , Ogino Takayuki , Takahashi Hidekazu , Uemura Mamoru , Mizushima Tsunekazu , Doki Yuichiro , Eguchi Hidetoshi 
Published: November 2023

AbstractCirculating tumor cells (CTCs) play an important role in metastasis and recurrence. However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal cancer (CRC). CRC with high expression of POU5F1 has a poor prognosis with a high incidence of liver metastatic recurrence. We aim to reveal the key cells promoting metastasis and identify treatment-resistant lineages with established EGFP-expressing organoids in two-dimensional culture (2DOs) under the POU5F1 promotor. POU5F1-expressing cells are highly present in relapsed clinical patients’ blood as CTCs. Sorted POU5F1-expressing cells from 2DOs have cancer stem cell abilities and abundantly form liver metastases in vivo. Single-cell RNA sequencing of 2DOs identifies heterogeneous populations derived from POU5F1-expressing cells and the Wnt signaling pathway is enriched in POU5F1-expressing cells. Characteristic high expression of CTLA4 is observed in POU5F1-expressing cells and immunocytochemistry confirms the co-expression of POU5F1 and CTLA4. Demethylation in some CpG islands at the transcriptional start sites of POU5F1 and CTLA4 is observed. The Wnt/β-catenin pathway inhibitor, XAV939, prevents the adhesion and survival of POU5F1-expressing cells in vitro. Early administration of XAV939 also completely inhibits liver metastasis induced by POU5F1-positive cells.
Formation of the eclogites of the Atbashi complex, Kyrgyzstan, in a subduction zone mélange diapir
Authors: Sang Miao , Tan Zhou , Xiao Wenjiao , Mao Qigui , Wang Hao , Li Rui , Qiao Qingqing 
Published: November 2023

AbstractMuch debate exists concerning mechanisms of crustal material transfer from subducting slab to overlying mantle. Formation of mélange rocks by physical mixing of slab components within subduction plate interface is predicted to transfer their compositional signal to source of arc magmas by ascending as diapirs from slab-top. Despite being supported conceptually and through modeling, existence of these diapirs in global subduction architecture remains inconclusive. Here we use petrological observations, thermometry and thermodynamic modeling, combined with geochemical constraints and compilation of massive existing data, to investigate eclogites from a deeply buried mélange “package” in Kyrgyz Tianshan, southern Altaids. We find that various slab components physically mixed to form eclogitic mélange rocks at threshold depth of the subarc (i.e., ≥85 km). Index mineralogical and Pressure-Temperature records indicate a thermal history with substantial heating after peak burial to condition crossing wet solidus. Such translation, toward hot corner of mantle wedge, is short-lived around several hundred thousand to few million years, serving as first tangible evidence substantiating mélange diapirs propagate and dynamically mix with overlying mantle. Contemporaneous Late Carboniferous flare-up of regional arc magmatism with mélange diapir melting signal also advocates that non-negligible process of mantle wedge hybridization by buoyant mélange materials, to transfer volatile, generate arc lavas and regulate terrestrial geochemical cycles, stands.
Multi-station deep learning on geodetic time series detects slow slip events in Cascadia
Authors: Costantino Giuseppe , Giffard-Roisin Sophie , Radiguet Mathilde , Dalla Mura Mauro , Marsan David , Socquet Anne 
Published: November 2023

AbstractSlow slip events (SSEs) originate from a slow slippage on faults that lasts from a few days to years. A systematic and complete mapping of SSEs is key to characterizing the slip spectrum and understanding its link with coeval seismological signals. Yet, SSE catalogues are sparse and usually remain limited to the largest events, because the deformation transients are often concealed in the noise of the geodetic data. Here we present a multi-station deep learning SSE detector applied blindly to multiple raw (non-post-processed) geodetic time series. Its power lies in an ultra-realistic synthetic training set, and in the combination of convolutional and attention-based neural networks. Applied to real data in Cascadia over the period 2007–2022, it detects 78 SSEs, that compare well to existing independent benchmarks: 87.5% of previously catalogued SSEs are retrieved, each detection falling within a peak of tremor activity. Our method also provides useful proxies on the SSE duration and may help illuminate relationships between tremor chatter and the nucleation of the slow rupture. We find an average day-long time lag between the slow deformation and the tremor chatter both at a global- and local-temporal scale, suggesting that slow slip may drive the rupture of nearby small asperities.
The human right to climate adaptation
Authors: Bordner Autumn , Barnett Jon , Waters Elissa 
Published: November 2023

AbstractWe demonstrate that a right to climate change adaptation exists in a bundle of pre-existing human rights norms. This existing right provides clear principles to guide the implementation of climate adaptation in ways that are equitable and effective, obliging States to, inter alia, prioritise those whose rights are most at risk from climate change; maximise the adaptive capacity of individuals; preserve territory to protect the sovereign rights of peoples; and ensure that adaptation practices themselves do not harm human rights. Human rights law requires that these obligations be fulfilled without discrimination on any grounds, including economic judgements about the cost effectiveness of adaptation in small or remote countries or communities.
A five-level cold atomic system for the orbital angular momentum exchange based on a four-wave mixing setup
Authors: Ali E , Kamona S M Husein , Hussein T Kh , Abbas H A , Rasen F A , Alhassan M S , Hameed S M , Al-Saidi D N , Alawadi A , Alsalamy A 
Published: November 2023

Abstract
In this paper, we suggest a theoretical model for the exchange of the orbital angular momentum (OAM) state of laser fields in a real cold atomic system for realization in an experimental setup. By using four-wave mixing (FWM) processes, we study the spatial dependence of the new weak generated signal light under electromagnetically induced transparency conditions when one of the laser lights becomes an optical vortex. We discuss the spatial dependence of FWM processes via experimental parameters for different conditions of the OAM of vortex light. We have found that the intensity and phase distributions of the new generated light depends strongly on the OAM number of the optical vortex light. Moreover, we investigate the absorption spectrum of the new generated signal light for different OAM of the optical vortex light. Our obtained results may have potential applications in quantum information science.
Multipulse operation in Mamyshev oscillator: influence of external seed source
Authors: Nigam Anshuman , Gupta Pradeep K , Singh C P , Bhuvnesh  , Mukhopadhyay P K , Arya R , Dixit S K 
Published: November 2023

Abstract
We study the influence of an external seed source on the startup of a fiber Mamyshev oscillator (MO). Depending on the seed source parameters, while keeping MO parameters fixed, we observe diverse mode-locked operations from the MO, generating stable single, double, triple and even up to a group of seven pulses. The probability of the occurrence of such mode-locked operations is studied. There can be different operating regimes in a particular multipulse operation. We find that there is an optimum spectral width of the seed source for which the probability of generating mode-locked stable train of single pulses from a fiber MO is maximum. Further, we find that the power of the seed source has less influence on the mode-locking state of the fiber MO; however, the probability of single or double pulse operation is relatively higher than that of multipulse operation at higher power of the seed source. These experimental observations will enrich the database of multipulse patterns and help in understanding pulse dynamics in the fiber MO. Suitably chosen seed source parameters can generate the desired pulse pattern. Such tailored outputs could have prospective applications in laser micromachining and high bit rate data transfer in optical networks.
Access to stable, high pressure tokamak pedestals using local electron cyclotron current drive
Authors: Logan N.C. , Lyons B.C. , Knolker M. , Hu Q. , Cote T. , Snyder P. 
Published: November 2023

Abstract
Experiments on the DIII-D tokamak demonstrate that edge localized mode (ELM) stability can be manipulated using localized electron cyclotron current drive (ECCD) in conjunction with resonant magnetic perturbations (RMPs). The injection of counter-plasma-current edge ECCD reduces the RMP amplitude required to suppress ELMs and bifurcates the pedestal into a high-confinement regime with 7 kPA pedestal pressure. This is the first time such a high confinement regime has been accessed through the bifurcation from the ballooning stability branch predicted by existing models. These observations are consistent with modeled ECCD manipulation of magnetic islands induced by the RMPs.
Design of High Performance Triangular Fiber Bragg Grating Temperature Sensor using OptiSystem and OptiGrating Software
Authors: Naim Nani Fadzlina , Zulkifli Nur Ainie Tasnim Muhamad , Supian Latifah Sarah , Ya’acob Norsuzila , Yusof Azita Laily , Muhamad Wan Norsyafizan W. , Sarnin Suzi Seroja 
Published: November 2023

Abstract
This paper presents on the design of high performance triangular Fiber Bragg Grating (FBG) as temperature sensor. This triangular FBG is designed and simulated using OptiGrating Software. The Triangular FBG design is exported to OptiSystem Software. In the OptiSystem software, the overall triangular FBG temperature sensor system is designed and simulated. It found that the triangular FBG has higher temperature sensitivity which is 37.5pm/°C than the standard FBG which is around 13pm/°C. It also has high linearity of 99.2% which specifies the consistency of wavelength shift as the temperature is increased. It also has higher resolution due to its sharp peak and smaller bandwidth.
ASE from polymer films embedded with silver nanowires
Authors: Altamimi Tamim Abdullah , Kamil Wan Maryam Wan Ahmad 
Published: November 2023

Abstract
Silver nanowires (AgNWs) were developed on glass substrate using polyol method at 160 °C. Centrifuge at 1500 rpm for different ratio of ethanol was done to extract the AgNWs. Rhodamine 6G (R6G) was then applied at different thicknesses. Enhanced emission from R6G was observed when the concentrations used are at 40 µL and 20 µL. Overall results indicate promising potential for enhancing plasmon resonances in optical emission by utilising silver nanowires as scatterers and R6G as the gain medium.
Design and modelling of modulated cw laser generation in lidar application
Authors: Zainal D A , Ahmeed M M I , Supian L S 
Published: November 2023

Abstract
In this work, we designed a configuration that may be used for direct detection of light, detection and ranging sensing method based on generated continuous wave laser and characterized by range measurements. The generation of modulated laser distance is studied and analysed by several distances where modulation of laser signal is utilized. The modelling configuration consisted of transmission module that comprises of signal generator, modulator, and propagation module, object target, and receiver modules comprises of photodetector, amplifier, filter, and visualizers. The design and configuration were developed by Optisystem layout, and the study and analysis are done by simulation using the developed model. A subsystem of range measurement was designed to detect varied distances of detection of target object by the generated modulation of continuous wave laser at 10, 50, 100 and 200 meters respectively. The results discussed were based on the power received and frequency given by different detection ranges. Analysis shows that the detection scheme is sensitive to the received electromagnetic radiation and the signal is better at shorter haul based on the generated modulation of the continuous wave source and the signal deteriorated as target distance is increased.
Nucleation of recrystallization
Authors: Jensen D Juul , Zhang Y 
Published: November 2023

Abstract
This paper reviews the mechanisms of nucleation during recrystallization of cold deformed, single phase polycrystalline metals including metals with large particles. The classic nucleation theories and conceptions are shortly summarized, while the main focus is on our results from recent 3D studies of nucleation. The novel results are related to the classic nucleation ideas and agreement/disagreement as well as new suggestions are discussed. More specifically the paper covers recovery leading to intragranular nucleation, bulge nucleation (which is often referred to as strain induced boundary migration), and particle stimulated nucleation. Also, effects of clustered nucleation, crystallographic orientation relationships and residual stress are considered. Finally future studies are suggested, which we consider key to advancing the understanding of nucleation during recrystallization.
Effect of α+β phase rolling and aging treatment on laminated bimodal structure in high temperature titanium alloy
Authors: Hu J F , Qi P , Yin J M , Hou X K , Li B L , Wen S P , Wei W , Nie Z R 
Published: November 2023

Abstract
In this work, we have prepared a novel laminated bimodal structure with layer-by-layer distribution of αp and αs phase in high temperature titanium alloy by α+β phase rolling and aging treatment. The lamellar bimodal microstructure is comprised of long-primary αp and secondary αs phase in the Ti-6.0Al-3Sn-5Zr-0.5Mo-1.0Nb-1.0Ta-0.4Si-0.2Er alloy. During α+β phase rolling at 990 °C, the primary αp grain deformed to elongated layer structure, while the lamella secondary αs deformed to kinked and broken chaos morphology. After 800 °C for 1h stabilization and 700 °C for 5h aging treatment, the thickness of the elongated αp layer slightly grew, while the kinked and broken αs were recovered and partially recrystallized to form a layered fine grain structure. The lamellar bimodal microstructure, i.e., elongated primary αp with layered bimodal αs phase has enhanced strength and ductility of the high temperature titanium alloy. This enhanced strength and toughness is mainly attributed to the lamellae αp structure and layered fine αs grain formed by hot rolling and aging treatment.
The influence of deformation texture on nucleation and growth of cube grains in aluminium
Authors: Paul H , Miszczyk M M , Puchlerska S , Mania I 
Published: November 2023

Abstract
The influence of deformation texture on the initial stages of recrystallization of deformed pure Al single crystals and commercial AA1050 alloy were characterized. To precisely quantify the orientation relationship between nuclei and simple deformation structures, single crystalline samples of stable Br(110) [1-1-2] and semi-stable S’(234) [20-28 11] orientations, were plane strain compressed (PSC) to 40% to develop a dominant homogeneous microstructure composed of two sets of microbands. The samples were then lightly annealed to reach the initial stage of primary recrystallization. The results on single crystals were related to the behaviour of the polycrystalline samples in state after hot-rolling then PSC to the same degree and lightly annealed. SEM/EBSD analyses of single crystalline samples demonstrate that the orientations of recrystallized grains are limited to a certain number of orientation groups. However, the orientations of the as-deformed state are not retained in the orientations of new grains. Deformed samples with Br orientation do not show the formation of cube grains during recrystallization, whereas strong nucleation of cube-oriented grains is observed in homogeneously and heterogeneously deformed areas in the semi-stable S’ orientation, despite the cube-oriented nuclei not present in the as-deformed structure. The recrystallization texture components of the AA1050 alloy were related to the standard β-fibre texture formed during the previous cold deformation. Cube grains formed intensively in PSC polycrystalline samples, primarily in association with as-deformed areas with near four variants of S(124) [21-1] and S’ orientations and were characterized by local misorientations around the <111> axes.
Obtaining synergy of strength and ductility in low-density steel via two-step annealing treatment
Authors: Li Tianyi , Hu Qiwen , Ma Guoqiang , Liu Wenyue , Wu Guilin , Mao Xinping 
Published: November 2023

Abstract
Adding light elements such as Mn and Al to steels can significantly reduce the density and obtain good strength-ductility of steels, making it a suitable choice for the development of lightweight materials. In this study, the microstructure and mechanical properties of Fe-30Mn-10Al-1C low density steel after cold rolling and annealing heat treatment were investigated. The results demonstrated that nano-sized κ-carbides are unevenly precipitated during the low temperature (500 °C) annealing process, which pin austenite grain boundaries and restrain the growth of austenite grains during the subsequent high temperature (900 °C) annealing process. As a consequence, the two-step annealed sample exhibits a fine and heterogeneous grain structure, leading to improvements of approximately 30 MPa in the yield strength to 752 MPa while keeping almost the same uniform elongation. Compared to the one step annealed sample (900 °C annealed for 3 minutes), the two-step annealed sample can achieve a high strength-ductility product (58 GPa·%) and an excellent impact toughness (128 J/cm2 at -40 °C).
Dynamic recrystallization behavior of a newly developed Ni-Fe based superalloy during hot deformation
Authors: Liu Peng , Yan Jingbo , Lu Jintao , Li Pei , Li Limin , Zhang Peng , Zhou Yongli , Huang Jinyang , Chen Biqiang , Yang Zhen , Dang Yingying , Yin Hongfei , Yuan Yong 
Published: November 2023

Abstract
The dynamic recrystallization (DRX) behavior of a newly developed Ni-Fe based superalloy was investigated by isothermal compression tests performed at a wide temperature range of 950 to 1200 °C with a strain rate range from 0.01 to 10 s−1 under a true strain of 0.916. The electron backscatter diffraction (EBSD) technique was employed to investigate the effect of strain rate and temperature on the microstructure evolution. The results revealed that the size and volume fraction of DRX grains increased with increasing the temperature. The volume fraction of DRX grains first decreased and then increased with increasing the strain rate during the hot deformation. The preferred orientation of the overall grains changed from <001>//CD to <110>//CD with increasing the strain rate during the deformation at 950 °C, while the preferred orientation of overall grains consistently maintained as <001>//CD during the deformation at 1200 °C. DDRX was the dominant mechanism during the deformation, while CDRX was proved to be an assistant mechanism and was promoted with increasing the strain rate.
Influences of alloying composition and cooling rate on precipitation behaviors of primary Al3Zr-D023 intermetallics in Al-Mg-Li-Zr alloys
Authors: Liu Tao , Jiang Huixue , Wang Bin , Chen Huabiao , Wu Daoxiang , Luo Haiyun , Yang Rongdong , Lin Lin 
Published: November 2023

Abstract
In the industrial process, the potential benefit of Al3Zr precipitates is usually weakened because coarse Al3Zr precipitates have no positive effect on the dynamic recovery, recrystallization and grain growth. Effects of alloying composition and cooling rate on precipitation and growth behaviors of primary Al3Zr-D023 intermetallics were investigated, especially in a large compositional space. Four types of elements exist in the Al3Zr-D023 phase. Increasing initial Mg, Li, Zr, and Ti contents is beneficial to increase the start precipitation temperature of Al3Zr-D023 particles. Increasing initial Mg, Li, Zr, Ti contents and reducing cooling rate are beneficial to increase the mean length, decrease the nucleation rate and the number density of Al3Zr-D023 precipitates. Furthermore, Zr and Ti element contents show a strong positive correlation with the start precipitation temperature and the final length of Al3Zr-D023 precipitates. Reducing slightly initial Ti content is beneficial to reduce the final length of Al3Zr-D023 precipitates. Furthermore, two empirical equations were obtained using the multiple linear regression method, which reveal the complex interactions rather than single-element effect of Mg, Li, Zr, and Ti.
Artifacts of particle stimulated nucleation in 2D and 3D—a numerical analysis
Authors: Knipschildt E F F , Zhang Y B , Yu T , Lei X , Sanders R E , Jensen D Juul 
Published: November 2023

Abstract
Particle stimulated nucleation is considered to be the dominating nucleation mechanism in many general industrially relevant metallic alloys undergoing thermomechanical processing. In metallography, nuclei are typically defined as particle stimulated if they touch or are close to a second phase particle. In the present work, we numerically investigate how much miscategorisation there can be in this type of analysis. This is done by finding how many nuclei that statistically are next to a particle if all the nuclei and particles are randomly distributed in space. Furthermore, as particle stimulated nucleation is typically quantified by 2D experimental methodologies, it is additionally analysed if an area can correctly quantify the effect of the nucleation mechanism in a bulk sample.
Simulating the kinetics of recrystallization in Aluminum alloys
Authors: Sidor J J , Chakravarty P , Bátorfi J Gy 
Published: November 2023

Abstract
This contribution presents a brief overview of the simulation of recrystallization kinetics in metals. The study focuses on the annealing phenomena in a single-phase 1050 aluminum alloy of technical purity. To reveal the true nature of recrystallization, the kinetics is discussed by the well-establishes Johnson–Mehl–Avrami–Kolmogorov (JMAK) approach, while the constants of this model are related to the energy stored during deformation, nucleation rate, velocity of grain boundary, and grain boundary energy. The listed physical quantities are derived from different models, while the performance of the combined approach was tested for the cases where the diversity of driving forces for recrystallization was ensured by different straining levels. The softening of the material during annealing was evaluated by the microhardness. It was shown that the kinetics of recrystallization is strongly influenced by the stored energy and the process can be simulated by employing the JMAK equation.