bluuebunny/crossref_metadata_2025_split huggingface dataset:
Priestly Offering: Law and Narrative in the Aramaic Levi Document
Authors: Mali Hillel 
Published: January 2024

AbstractIn this article, I propose a new reading for both law and narrative in the Aramaic Levi Document (ALD). In the first section, I show that the passage of “the law of the priesthood” pertains to the daily morning service in the Temple. In the second section, I suggest that the narrative that contains these instructions, in which Isaac speaks to Levi at Abraham’s home, exegetically connects the laws to the story of Isaac, whose father offered him up on an altar, and reflects a priestly theology that views the priest himself as an offering.
’Ενευλογηθήσονται as a Speech Action Middle in Genesis 12:3b LXX
Authors: York Dan 
Published: January 2024

AbstractInterpreters unanimously read ἐνευλογηθήσονται in Gen 12:3b LXX as a passive. Good evidence, however, exists to challenge and problematize this conclusion. Recent linguistic studies on the ancient Greek middle voice reveal that aorist and future -θη- forms express a semantically middle domain. When we reexamine the word ἐνευλογέομαι within this light, a better option emerges for seeing its -θη- forms as manifestations of speech actions within this middle domain. In their own unique ways, the LXX as well as Philo, Paul, and Acts further corroborate this alternative. As a result, we may read ἐνευλογηθήσονται in Gen 12:3b LXX as a speech action middle: “to pronounce blessings.” The proposed reading promotes a better understanding of Abraham within Genesis LXX. Rather than a means to an end, Abraham remains at the center of God’s blessing as the earth’s families cry out: “God make me like Abraham!”
Acoustic correlates of word stress and focus marking in Udmurt
Authors: Borise Lena , Georgieva Ekaterina 
Published: January 2024

AbstractIn this paper, we investigate the prosodic realization of stress and focus in Udmurt (Uralic, Permic). According to the literature, Udmurt has fixed final stress, but also has several sets of morphosyntactic exceptions with initial stress. We report the results of two production studies. The first one targets nominals with final stress, and the second one investigates the stress properties of minimal pairs consisting of (i) indicative verbs (prs.3sg; final stress) and (ii) imperative verbs (imp.2sg/pl; initial stress). To control for the information-structural contexts, the test words are studied in contexts that elicit narrow focus either on the test word (‘F’ condition) or on another constituent (‘non-F’ condition). The results show that all four acoustic parameters surveyed in the paper – duration, intensity, fundamental frequency (f0), and first formant (F1) values – participate in stress marking in Udmurt. The results for focus marking vary by study and demonstrate that all cues except for intensity may be involved in focus marking. At the same time, we find wide interspeaker variation with respect to the acoustic cues marking stress and/or focus. Finally, we outline a preliminary Autosegmental-Metrical interpretation of our f0 results; a full account of Udmurt intonation awaits further research.
Genotyping of Toxoplasma gondii in domestic animals from Campeche, México, reveals virulent genotypes and a recombinant ROP5 allele
Authors: Rico-Torres Claudia Patricia , Valenzuela-Moreno Luis Fernando , Robles-González Elvira , Cruz-Tamayo Alvar Alonzo , Huchin-Cab Miguel , Pérez-Flores Jonathan , Xicoténcatl-García Lizbeth , Luna-Pastén Héctor , Ortiz-Alegría Luz Belinda , Cañedo-Solares Irma , Cedillo-Peláez Carlos , García-Lacy Fernando , Caballero-Ortega Heriberto 
Published: January 2024

AbstractToxoplasma gondii has at least 318 genotypes distributed worldwide, and tropical regions usually have greater genetic diversity. Campeche is a state located in the southeastern region of México and has favourable climate conditions for the replication and dissemination of this protozoan, similar to those in South American countries where broad genetic diversity has been described. Thus, in this study, 4 T. gondii isolates were obtained from tissues of stray dogs and free-range chickens in Campeche, México, and were genotyped by Mn-PCR-RFLP with 10 typing markers (SAG1, altSAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1 and Apico) and 5 virulence markers (CS3, ROP16, ROP17, ROP18 and ROP5) to provide new information about the distribution and virulence prediction of T. gondii genotypes. Two isolates of T. gondii genotype #116 and 2 of genotype #38 were obtained from stray dogs and chickens, respectively. The parasite load found in these species was between <50 and more than 35 000 tachyzoites per mg of tissue. Virulence marker genotyping revealed a recombinant 1&3 ROP5 RFLP pattern in 2 ToxoDB #116 isolates with no prediction of virulence in a murine model, while in the 2 ToxoDB #38 isolates, the ROP18/ROP5 combination predicted high virulence. Considering all the typed markers, there is a predominance of type I and III alleles, as constantly reported for the isolates characterized in various regions of México. It is crucial to determine their phenotype to corroborate the genetic virulence profile of the T. gondii isolates obtained in this study.
Early technology review: towards an expedited pathway
Authors: Levin Leslie , Sheldon Murray , McDonough Robert S. , Aronson Naomi , Rovers Maroeska , Gibson C. Michael , Tunis Sean Robert , Kuntz Richard E. 
Published: January 2024

Abstract

Objectives
Evidence development for medical devices is often focused on satisfying regulatory requirements with the result that health professional and payer expectations may not be met, despite considerable investment in clinical trials. Early engagement with payers and health professionals could allow companies to understand these expectations and reflect them in clinical study design, increasing chances of positive coverage determination and adoption into clinical practice.

Methods
An example of early engagement through the EXCITE International model using an early technology review (ETR) is described which includes engagement with payers and health professionals to better inform companies to develop data that meet their expectations. ETR is based on an early evidence review, a framework of expectations that guides the process and identified gaps in evidence. The first fourteen ETRs were reviewed for examples of advice to companies that provided additional information from payers and health professionals that was thought likely to impact on downstream outcomes or strategic direction. Given that limitations were imposed by confidentiality, examples were genericized.

Results
Advice through early engagement can inform evidence development that coincides with expectations of payers and health professionals through a structured, objective, evidence-based approach. This could reduce the risk of business-related adverse outcomes such as failure to secure a positive coverage determination and/or acceptance by expert health professionals.

Conclusions
Early engagement with key stakeholders exemplified by the ETR approach offers an alternative to the current approach of focusing on regulatory expectations. This could reduce the time to reimbursement and clinical adoption and benefit patient outcomes and/or health system efficiencies.
Log-concavity and relative log-concave ordering of compound distributions
Authors: Xia Wanwan , Lv Wenhua 
Published: January 2024

AbstractIn this paper, we compare the entropy of the original distribution and its corresponding compound distribution. Several results are established based on convex order and relative log-concave order. The necessary and sufficient condition for a compound distribution to be log-concave is also discussed, including compound geometric distribution, compound negative binomial distribution and compound binomial distribution.
Possessive pronouns in Welsh: Stylistic variation and the acquisition of sociolinguistic competence
Authors: Young Katharine , Durham Mercedes , Morris Jonathan 
Published: January 2024

AbstractThis paper examines possessive pronoun forms in Welsh, a feature thought to be undergoing change (Davies, 2016). First, we seek to add to the understanding about how and in which stylistic contexts these forms are used. Second, we examine whether students in Welsh-medium schools with different home language backgrounds show the same sociolinguistic competence. In contrast to what is prescribed in many grammar books, the colloquial form mam fi ‘my mum’ is used at much higher rates than the traditional literary fy mam and sandwich variants fy mam i. This is particularly the case in more casual styles. We also find differences between north and south Wales in overall rates of use, but within the two schools studied, the English home language students broadly show the same patterns and constraints as the Welsh home language students, underlining that language background does not affect the acquisition of sociolinguistic competence.
Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer’s disease
Authors: Welhaf Matthew S. , Wilks Hannah , Aschenbrenner Andrew J. , Balota David A. , Schindler Suzanne E. , Benzinger Tammie L.S. , Gordon Brian A. , Cruchaga Carlos , Xiong Chengjie , Morris John C. , Hassenstab Jason 
Published: January 2024

AbstractObjective:Maintaining attention underlies many aspects of cognition and becomes compromised early in neurodegenerative diseases like Alzheimer’s disease (AD). The consistency of maintaining attention can be measured with reaction time (RT) variability. Previous work has focused on measuring such fluctuations during in-clinic testing, but recent developments in remote, smartphone-based cognitive assessments can allow one to test if these fluctuations in attention are evident in naturalistic settings and if they are sensitive to traditional clinical and cognitive markers of AD.Method:Three hundred and seventy older adults (aged 75.8 +/− 5.8 years) completed a week of remote daily testing on the Ambulatory Research in Cognition (ARC) smartphone platform and also completed clinical, genetic, and conventional in-clinic cognitive assessments. RT variability was assessed in a brief (20-40 seconds) processing speed task using two different measures of variability, the Coefficient of Variation (CoV) and the Root Mean Squared Successive Difference (RMSSD) of RTs on correct trials.Results:Symptomatic participants showed greater variability compared to cognitively normal participants. When restricted to cognitively normal participants, APOE ε4 carriers exhibited greater variability than noncarriers. Both CoV and RMSSD showed significant, and similar, correlations with several in-clinic cognitive composites. Finally, both RT variability measures significantly mediated the relationship between APOE ε4 status and several in-clinic cognition composites.Conclusions:Attentional fluctuations over 20–40 seconds assessed in daily life, are sensitive to clinical status and genetic risk for AD. RT variability appears to be an important predictor of cognitive deficits during the preclinical disease stage.
Emergence timing of smallflower umbrella sedge (Cyperus difformis), barnyardgrass (Echinochloa crus-galli), and bearded sprangletop (Leptochloa fusca spp. fascicularis) in California water-seeded rice
Authors: Driver Katie E. , Becerra-Alvarez Aaron , Mesgaran Mohsen B. , Al-Khatib Kassim 
Published: January 2024

Abstract
Late-season weed emergence in California rice fields complicates decisions concerning the timing of control measures. The objective of this study was to predict the emergence of three problematic weed species in rice using thermal time models. Smallflower umbrella sedge, barnyardgrass, and bearded sprangletop seedlings were counted and removed daily at three locations across the Sacramento Valley rice-growing region in 2018. The accumulation of thermal time (growing degree days; GDD) commenced with the initial flooding of the fields at each location, utilizing the specific base temperatures corresponding to each species. The pattern of emergence as a function of GDD was modeled with a Weibull function. Root-mean-square values for comparing actual and model-predicted cumulative emergence values were 6% to 23%. Percent cumulative emergence initially increased rapidly for smallflower umbrella sedge and reached 90% emergence with accumulation of 13 GDD. Barnyardgrass emerged after smallflower umbrella sedge and reached 90% emergence with an accumulation of 124 GDD. Bearded sprangletop had a delay of 64 GDD compared to barnyardgrass to reach first emergence and reached 90% emergence at 215 GDD. The period of weed emergence at all field sites differed across the three species and led to a continuous spectrum of weed emergence over time. This study characterizes the emergence of three economically important rice weeds and provides useful information for the timing of weed management. Typical herbicide applications on the day of seeding may have less efficacy on the late-emerging weeds, causing reduced weed control. Delayed herbicide application, overlay of residual herbicides, or use of herbicides with longer residual activity are suggested to control late-emerging weeds.
Automated Nighttime Cloud Detection Using Keograms When Aurora Is Present
Authors: English Alex , Stuart David J. , Hampton Donald L. , Datta‐Barua Seebany 
Published: January 2024

AbstractWe present a binary hypothesis test for detecting clear sky in auroral all‐sky images based on single‐wavelength keograms. The coefficient of variation c, the ratio of the sample standard deviation to the mean over elevation angle along the meridian, is the test statistic. After image‐correcting keograms and excluding dark sky intervals, detection performance is compared to true conditions as determined by Advanced Very High Resolution Radiometer satellite imagery. The cloud mask, an index of cloud cover, is selected at the corresponding nearest time and location to the site of a meridian spectrograph at Poker Flat Research Range. With training data from 2014 to 2016, theoretical Rayleigh distributions fit to the histograms show a decision threshold of 0.40 could yield an accuracy of about 80%. Separately, we numerically compute the false alarm and missed detection statistics of the greenline 557.7 nm emission and of the redline 630.0 nm emission. We find a threshold of 0.25 for the greenline c maximizes the percent of events correctly identified at 76%. Applied to testing data from 2015 to 2017, the 0.25 threshold yields an accuracy of 68%. Diffuse aurora can have coefficient of variation around 0.2 to 0.5, which would be included by the numerical minimum, but partly excluded by the theoretical model obtained. Numerical results are a few percent worse for the redline emission.
Participatory Causal Loop Diagrams Building for Supporting Decision‐Makers Integrating Flood Risk Management in an Urban Regeneration Process
Authors: Coletta Virginia R. , Pagano Alessandro , Pluchinotta Irene , Zimmermann Nici , Davies Michael , Butler Adrian , Fratino Umberto , Giordano Raffaele 
Published: January 2024

AbstractSeveral modeling tools commonly used for supporting flood risk assessment and management are highly effective in representing physical phenomena, but provide a rather limited understanding of the multiple implications that flood risk and flood risk reduction measures have on highly complex systems such as urban areas. In fact, most of the available modeling tools do not fully account for this complexity—and related uncertainty—which heavily affects the interconnections between urban systems evolution and flood risk, ultimately resulting in an ineffective flood risk management. The present research proposes an innovative methodological framework to support decision‐makers involved in an urban regeneration process at a planning/strategic level, accounting for the multi‐dimensional implications of flood risk and of different flood risk management strategies. The adopted approach is based on the use of System Thinking principles and participatory System Dynamics modeling techniques, and pursues an integration between scientific and stakeholder knowledge. Reference is made to one of the case studies of the CUSSH and CAMELLIA projects, namely Thamesmead (London), a formerly inhospitable marshland currently undergoing a process of urban regeneration, and perceived as being increasingly vulnerable to flooding. It represents an interesting opportunity for building a replicable modeling approach to integrate urban development dynamics with flood risk, ultimately supporting policy and decision‐makers in identifying mitigation/prevention measures and understanding how they could help achieve multi‐dimensional benefits (e.g., environmental, social and economic).
A Decade of Short‐Period Earthquake Rupture Histories From Multi‐Array Back‐Projection
Authors: Vera Felipe , Tilmann Frederik , Saul Joachim 
Published: January 2024

AbstractTeleseismic back‐projection imaging has emerged as a powerful tool for understanding the rupture propagation of large earthquakes. However, its application often suffers from artifacts related to the receiver array geometry. We developed a teleseismic back‐projection technique that can accommodate data from multiple arrays. Combined processing of P and pP waveforms may further improve the resolution. The method is suitable for defining arrays ad‐hoc to achieve a good azimuthal distribution for most earthquakes. We present a catalog of short‐period rupture histories (0.5–2.0 Hz) for all earthquakes from 2010 to 2022 with MW ≥ 7.5 and depth less than 200 km (56 events). The method provides automatic estimates of rupture length, directivity, speed, and aspect ratio, a proxy for rupture complexity. We obtained short‐period rupture length scaling relations that are in good agreement with previously published relations based on estimates of total slip. Rupture speeds were consistently in the sub‐Rayleigh regime for thrust and normal earthquakes, whereas a tenth of strike‐slip events propagated at supershear speeds. Many rupture histories exhibited complex behaviors, for example, rupture on conjugate faults, bilateral propagation, and dynamic triggering by a P wave. For megathrust earthquakes, ruptures encircling asperities were frequently observed, with downdip, updip, and balanced patterns. Although there is a preference for short‐period emissions to emanate from central and downdip parts of the megathrust, emissions updip of the main asperity are more frequent than suggested by earlier results.
Dose modification dynamics of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) from the PACE and OPTIC trials
Authors: Jabbour Elias , Apperley Jane , Cortes Jorge , Rea Delphine , Deininger Michael , Abruzzese Elisabetta , Chuah Charles , DeAngelo Daniel J. , Hochhaus Andreas , Lipton Jeffrey H. , Mauro Michael , Nicolini Franck , Pinilla-Ibarz Javier , Rosti Gianantonio , Rousselot Philippe , Shah Neil P. , Talpaz Moshe , Vorog Alexander , Ren Xiaowei , Kantarjian Hagop 
Published: January 2024

AbstractPonatinib, the only approved all known-BCR::ABL1 inhibitor, is a third-generation tyrosine-kinase inhibitor (TKI) designed to inhibit BCR::ABL1 with or without any single resistance mutation, including T315I, and induced robust and durable responses at 45 mg/day in patients with CP-CML resistant to second-generation TKIs in the PACE trial. However, cardiovascular toxicities, including arterial occlusive events (AOEs), have emerged as treatment-related AEs within this class of TKIs. The OPTIC trial evaluated the efficacy and safety of ponatinib using a novel, response-based, dose-reduction strategy in patients with CP-CML whose disease is resistant to ≥2 TKIs or who harbor T315I. To assess the dose-response relationship and the effect on the safety of ponatinib, we examined the outcomes of patients with CP-CML enrolled in PACE and OPTIC who received 45 mg/day of ponatinib. A propensity score analysis was used to evaluate AOEs across both trials. Survival rates and median time to achieve ≤1% BCR::ABL1IS in OPTIC were similar or better than in PACE. The outcomes of patients with T315I mutations were robust in both trials. Patients in OPTIC had a lower exposure-adjusted incidence of AOEs compared with those in PACE. This analysis demonstrates that response-based dosing for ponatinib improves treatment tolerance and mitigates cardiovascular risk.
The effect of aromatherapy with Lavender-Neroli oil and music in management of pediatric dental anxiety: a randomized control trial
Authors: Abdalhai Rama , Kouchaji Chaza , Alkhatib Rasha 
Published: January 2024

Abstract
Aim
This study aimed to evaluate the efficacy of aromatherapy with Lavender-Neroli essential oil combined with background music in reducing dental anxiety and pain during anesthesia in children.

Materials and methods
A total of 56 children aged 6–10 years old who needed dental treatment with inferior alveolar nerve injection (IANB) were randomly divided into two groups: Group 1 (Experimental, n = 28) aromatherapy with music group, and Group 2 (Control, n = 28) the placebo group. Children in the group 1 were asked to inhale the aromatic blend of Lavender-Neroli essential oil using a nasal mask similar to one that is used for nitrous oxide after modifying it by adding a 3D printed box on its circle hole and listening to their favorite music as a background before 5 min and during anesthesia, meanwhile in the placebo group children were asked to wear an empty nasal mask. Anxiety and pain were been assessed before and after anesthesia using the self-report anxiety scale Facial image scale (FIS), Observational pain assessment scale Face-Legs-Activity-Cry-Consolability (FLACC), heart rate, SPO2 saturation, diastolic and systolic blood pressure.

Results
Dental anxiety and vital signs except SPO2 saturation were significantly lower in the aromatherapy with music group when compared to the control group (p < 0.05), with no differences in pain perception between groups (p = 0.176).

Conclusions
Aromatherapy with Lavender-Neroli oil combined with music seems to be a useful and safe non-pharmacologic technique for managing dental anxiety in children.
Utility of the refined EBMT diagnostic and severity criteria 2023 for sinusoidal obstruction syndrome/veno-occlusive disease
Authors: Ichikawa Hiroya , Yakushijin Kimikazu , Kurata Keiji , Tsuji Takahiro , Takemoto Naoko , Joyce Miki , Okazoe Yuri , Takahashi Ruri , Matsumoto Sakuya , Sakai Rina , Kitao Akihito , Miyata Yoshiharu , Saito Yasuyuki , Kawamoto Shinichiro , Yamamoto Katsuya , Ito Mitsuhiro , Murayama Tohru , Matsuoka Hiroshi , Minami Hironobu 
Published: January 2024

AbstractSinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT). Early diagnosis of SOS/VOD is associated with improved clinical outcomes. In 2023, the refined European Society for Blood and Marrow Transplantation diagnostic and severity criteria (refined EBMT criteria 2023) have been advocated. The revision has introduced new diagnostic categories, namely; probable, clinical, and proven SOS/VOD. In addition, the Sequential Organ Failure Assessment (SOFA) score has been newly incorporated into the SOS/VOD severity grading. We performed a retrospective analysis to evaluate the utility of these criteria. We analyzed 161 cases who underwent allogeneic HSCT. We identified 53 probable, 23 clinical, and 4 proven SOS/VOD cases. Probable SOS/VOD was diagnosed a median of 5.0 days earlier (interquartile range: 2–13 days, P < 0.001) than that of clinical SOS/VOD. The development of probable SOS/VOD alone was associated with a significantly inferior survival proportion compared to non-SOS/VOD (100-day survival, 86.2% vs. 94.3%, P = 0.012). The SOFA score contributed to the prediction of prognosis. Consequently, the refined EBMT criteria 2023 demonstrated the utility of SOS/VOD diagnosis and severity grading. Further investigations and improvements in these criteria are warranted.