bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway
Authors: Han Daewon , Kim Deokryong , Kim Haeil , Lee Jeonga , Lyu Jungmook , Kim Jong-Seok , Shin Jongdae , Kim Jeong Sig , Kim Do Kyung , Park Hwan-Woo 
Published: November 2023

Introduction: Metabolism-associated fatty liver disease (MAFLD) is a global health concern because of its association with obesity, insulin resistance, and other metabolic abnormalities. Methylsulfonylmethane (MSM), an organic sulfur compound found in various plants and animals, exerts antioxidant and anti-inflammatory effects. Here, we aimed to assess the anti-obesity activity and autophagy-related mechanisms of Methylsulfonylmethane.Method: Human hepatoma (HepG2) cells treated with palmitic acid (PA) were used to examine the effects of MSM on autophagic clearance. To evaluate the anti-obesity effect of MSM, male C57/BL6 mice were fed a high-fat diet (HFD; 60% calories) and administered an oral dose of MSM (200 or 400 mg/kg/day). Moreover, we investigated the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin complex 1 (mTORC1)/UNC-51-like autophagy-activating kinase 1 (ULK1) signaling pathway to further determine the underlying action mechanism of MSM.Results: Methylsulfonylmethane treatment significantly mitigated PA-induced protein aggregation in human hepatoma HepG2 cells. Additionally, Methylsulfonylmethane treatment reversed the PA-induced impairment of autophagic flux. Methylsulfonylmethane also enhanced the insulin sensitivity and significantly suppressed the HFD-induced obesity and hepatic steatosis in mice. Western blotting revealed that Methylsulfonylmethane improved ubiquitinated protein clearance in HFD-induced fatty liver. Remarkably, Methylsulfonylmethane promoted the activation of AMPK and ULK1 and inhibited mTOR activity.Conclusion: Our study suggests that MSM ameliorates hepatic steatosis by enhancing the autophagic flux via an AMPK/mTOR/ULK1-dependent signaling pathway. These findings highlight the therapeutic potential of MSM for obesity-related MAFLD treatment.
Elevated high sensitive C-reactive protein in fibromyalgia
Authors: Beiner Eva , Brenner Miguel Sergio , Friederich Hans-Christoph , Tesarz Jonas ,   PerPAIN Consortium
Published: November 2023

IntroductionFibromyalgia syndrome (FMS) is a complex chronic pain condition characterized by widespread pain and tenderness, fatigue, and sleep disturbances. Currently, factors contributing to FMS are considered to be multifactorial, and the involvement of inflammatory processes is a question of debate.ObjectiveThe aims of this study were (1) to assess whether serum concentrations of high-sensitivity C-reactive protein (hsCRP) differ between individuals diagnosed with FMS and pain-free controls, (2) to determine whether these differences are associated with clinical symptoms, and (3) to explore whether the observed differences can be explained by specific covariates such as age, weight, and smoking status.MethodsAn ANOVA was applied to identify differences of hsCRP levels between FMS and pain-free controls and an analysis of covariance (ANCOVA) was performed to investigate the dependencies of hsCRP with respect to covariates. To assess the reliability of our findings, we also utilized a Bayesian robust estimation model to determine the level of confidence associated with our results.ResultsThe results showed that individuals with FMS had higher hsCRP levels compared to healthy controls [F(1,106) = 8.802, p &lt; 0.001] and that higher hsCRP levels were significant correlated with a higher symptom burden (r = 0. 287, p = 0.008) and more tender points (r = 0.307, p = 0.005). Further, hsCRP levels were significantly associated with weight (η2 = 0.154, p &lt; 0.001), but independent of age (η2 = 0.005, p = 0.42), smoking status (η2 = 0.002, p = 0.623), or gender (η2 = 0.0045, p = 0.437), which resulted in an insignificant group effect between FMS and controls (η2 = 0.029, p = 0.052), even after controlling for covariates.ConclusionIn conclusion, this study provides evidence that sub-inflammatory processes correlate with clinical symptoms, which can be partly attributed to differences in weight, but cannot be fully explained by them. Further research is needed to elucidate the mechanisms underlying the association between hsCRP and FMS and to explore the potential therapeutic implications of targeting hsCRP in the management of FMS.
Homer 1 genotype AA variant relates to congenital splay leg syndrome in piglets by repressing Pax7 in myogenic progenitors
Authors: Schumacher Toni , Reyer Henry , Maak Steffen , Röntgen Monika 
Published: November 2023

IntroductionPorcine congenital splay leg syndrome (PCS) is a major birth defect in piglets, resulting in lameness and high mortality rates. The multifactorial pathogenesis of PSC is not well understood but includes a polygenic inheritance.MethodsHere, in addition to morphological investigations, we characterized the expression of myogenic genes and functional (proliferation and differentiation) properties of myogenic precursor/satellite cells (SATCs) in 1 day-old PCS piglets, non-affected littermates (LCs), and piglets from PCS-free healthy litters (HCs). In addition, PCS phenotypes were related to the SNP Homer1_rs325197091 within the Homer1 locus, which has been identified as a potential hereditary cause of PCS.Results and discussionSamples from musculus semitendinosus (ST) of PCS piglets had a higher proportion of type II fibers, reflecting myofiber immaturity. In addition, myofiber atrophy, a lower number of myonuclei per fiber (ST), and a higher apoptotic activity (in ST and longissimus dorsi muscle; LD) were found in the PCS group. A higher proportion of cycling committed myoblasts (Pax7+/Ki67+ cells) occurred in samples from PCS-affected piglets, and on the other hand, the mRNA expression of genes involved in differentiation (muscle differentiation 1; MyoD, myogenin; MyoG) was repressed compared with HCs. Cultured SATCs from PCS-affected animals showed a temporal shift in peak expression of Pax7, MyoD, and MyoG toward days 3 and 4 of their 7 days differentiation regime. In vitro experiments with isolated SATCs confirmed the lower differentiation potential and the delayed progression of the myogenic processes in cells from piglets with PCS phenotype. In addition, Pax7 and desmin were differently expressed in Homer1_rs325197091 genotype variants (GG, GA, and AA). Both genes showed the lowest expression in the homozygous AA-variant, which was most frequently found in PCS-affected animals. The homozygous AA-variant was also associated with lower expression of the truncated Homer1-subtype 205. Thus, we hypothesize that in PCS, the balance between Homer1 proteins and its signaling functions is changed in a way detrimental to the myogenic differentiation program. Our results demonstrated direct negative effects of the Homer1 AA genotype on Pax7 expression, but the exact mode of action still needs to be elucidated.
Multifunctional Polymer-Metal Lattice Composites via Hybrid Additive Manufacturing Technology
Authors: He Liu , Wang Peiren , Wang Lizhe , Chen Min , Liu Haiyun , Li Ji 
Published: November 2023

With increasing interest in the rapid development of lattice structures, hybrid additive manufacturing (HAM) technology has become a competent alternative to traditional solutions such as water jet cutting and investment casting. Herein, a HAM technology that combines vat photopolymerization (VPP) and electroless/electroplating processes is developed for the fabrication of multifunctional polymer-metal lattice composites. A VPP 3D printing process is used to deliver complex lattice frameworks, and afterward, electroless plating is employed to deposit a thin layer of nickel-phosphorus (Ni-P) conductive seed layer. With the subsequent electroplating process, the thickness of the copper layer can reach 40 μm within 1 h and the resistivity is around 1.9×10−8 Ω⋅m, which is quite close to pure copper (1.7 ×10−8 Ω⋅m). The thick metal shell can largely enhance the mechanical performance of lattice structures, including structural strength, ductility, and stiffness, and meanwhile provide current supply capability for electrical applications. With this technology, the frame arms of unmanned aerial vehicles (UAV) are developed to demonstrate the application potential of this HAM technology for fabricating multifunctional polymer-metal lattice composites.
¿Cuándo se escribió "El matadero"? Echeverría y la juventud perdida
Authors: Ansolabehere Pablo 
Published: November 2023

Este artículo se divide en dos partes. En la primera se ocupa de establecer cuál sería la fecha estimada de escritura de “El matadero”. En contra de la hipótesis de la inmediatez, es decir de que Echeverría escribió este texto entre 1839 y 1840, poco antes de partir al exilio y muy cerca del momento en que transcurre la acción del relato, se sostiene la hipótesis de la distancia: a partir de ciertos datos presentes en el texto y en la prensa anti rosista de fines de la década de 1830 y comienzos de la siguiente, se puede argumentar que es muy probable que “El Matadero” haya sido escrito por Echeverría luego del comienzo del Sitio Grande de Montevideo (cuya fecha de inicio es el 16 de febrero de 1843). En la segunda parte, y teniendo en cuenta la hipótesis de la distancia, este artículo analiza la sintonía de “El matadero” con la Ojeada retrospectiva (que Echeverría publica en Montevideo en 1846) y el lugar clave que ocupa lo joven en esta encrucijada histórica y textual.
A STUDY ON THE SATISFACTION OF TEACHERS AND STUDENTS OF COLLEGES AND UNIVERSITIES IN NANCHANG AREA ON THE CONSTRUCTION OF DIGITAL EDUCATIONAL RESOURCES SHARING
Authors: Zhou Zihan 
Published: November 2023

Driven by international trend of "resource sharing", the results of regional sharing practices in economically developed regions of China, and the successful demonstration of the Changbei Higher Education Library Alliance in Jiangxi Province, higher education institutions in the Nanchang area of Jiangxi Province are now embarking on a project of building and sharing digital education resources. The objective of the study was to determine the types of educational resources designed in the current digital educational resources sharing in Nanchang area, and to assess the satisfaction of teachers and students in Nanchang with the construction of digital educational resources sharing.
This paper uses a quantitative research method to investigate the satisfaction of teachers and students of Nanchang universities with the construction of digital educational resources sharing by extensively collecting domestic and foreign research data, drawing on domestic and foreign successful experiences, and combining theory and practice with a questionnaire survey method.As many teachers and students considered that the digital education resources provided by their schools were not rich and only average, and could only meet their basic teaching or learning needs. A significant proportion of teachers and students looked outside the school because the in-school resources could not meet their needs in terms of quality and quantity. Teachers and students are not satisfied with the digital education resources provided by their schools, with only some students and some teachers indicating that they are relatively satisfied or very satisfied.
STUDY ON COST CONTROL IN THE CONSTRUCTION INDUSTRY BASED ON VALUE CHAIN THEORY - TAKE CHANG'AN CONSTRUCTION COMPANY AS AN EXAMPLE
Authors: Wei Tinghe 
Published: November 2023

In the face of scarce resources and the law of competition for survival of the fittest, cost control is an eternal topic for enterprises. In traditional accounting, people tend to pay too much attention to the cost of product production. The control of cost is concentrated on the manufacturing cost within the enterprise, and only a single driving factor is the cause of the cost. This causes the traditional cost control to be more and more unable to adapt to the development of modern enterprises.
The research objectives of this paper were:

To analyze the structure of Chang'an Construction Company's value chain.
To analyze the cost control of Chang'an Construction Company when doing a project based on its value chain structure.

This paper adopts the case study method, starting from the theoretical foundation of value chain cost control, to study the cost control system based on the value chain of Chang'an Construction Company. It seeks to gain relevant insights and draw conclusions from the analysis.
Through the in-depth study of value chain cost control in Chang'an Construction Company, several important conclusions have been drawn. A professional bidding process lays the foundation for cost-effectiveness and project profitability. The region-specific strategy adopted by Chang'an Construction makes bid preparation relevant and effective. The division of cost management into preparation and construction phases is critical. Careful cost planning, based on comprehensive site analysis, guides spending during the construction phase. Ongoing monitoring and timely adjustments are critical to align with that plan. Post-completion is not only an end point but also a phase of reflection and optimization of strategy. Efficient resource allocation and regular stakeholder engagement at the end of a project not only reduce future costs but also enhance a company's reputation.
THE IMPACT OF THE EFFECT OF ORGANIZATIONAL CULTURE ON EMPLOYEE INNOVATION BEHAVIOR THE MEDIATING ROLE OF VALUE PROPOSITIONS
Authors: Zhang Zhicheng , Guo Hui 
Published: November 2023

The purpose of this study is to explore the relationship between organizational culture, employee innovative behavior, and value proposition, and to further analyze the influencing mechanisms involved. By using validated measurement tools, we investigated the effects of factors such as gender, age, and education on these variables, and examined the interactions between organizational culture and employee innovation behavior, and the mediating and moderating roles of value proposition therein. This study is based on the literature between 2018 and 2022, and a large amount of data was collected using questionnaire methods, and the data was processed using appropriate statistical analysis methods. It was found that factors such as gender, age and educational qualifications do not significantly influence the relationship between organizational culture, employee innovative behavior and value proposition. However, it was observed that there is a strong correlation between organizational culture and employee innovative behavior and organizational culture has a positive impact on employee innovative behavior. In addition, the value proposition played a mediating role between organizational culture and employee innovative behavior, but had no significant effect on the moderating role.These findings have important implications in both theory and practice. At the theoretical level, this study provides new perspectives and evidence on the relationship between organizational culture, employee innovation behavior, and value proposition. At the practical level, this study provides some insights to help organizations better understand and guide employee innovative behaviors and management strategies in different cultural contexts. However, there are some limitations in this study, such as limitations in sample selection and survey methodology. Future research could further delve into the relationship between these variables and consider more influencing factors and moderating variables.
THE IMPACT OF EXTERNAL SUPPLY CHAIN AND SUSTAINABLE COMPETITIVE ADVANTAGE ON THE PRODUCT INNOVATION PERFORMANCE: THE MODERATING ROLES OF INNOVATION TYPE
Authors: Mo Bin , Guo Hui 
Published: November 2023

This study delves into the intricate interplay between external supply chain dynamics, sustainable competitive advantage, innovation types, and product innovation performance. Through a comprehensive exploration, this research seeks to shed light on the relationships and their implications for organizations.
The conceptual framework was constructed by introducing demographic variables such as position, company type, capitalization, etc. The minimum acceptable sample size for this study was calculated to be 384 and 520 valid questionnaires were distributed and returned to the companies in different industries through stratified sampling method, and hypotheses were formulated. Through related research, it was concluded that there is a strong positive relationship between the effectiveness of the external supply chain and the product innovation performance of an organization, there is a significant positive relationship between sustainable competitive advantage and product innovation performance, and innovation type does not have a significant moderating effect on the relationship between the external supply chain and product innovation performance. This study lays the groundwork for future research to explore deeper nuances in external supply chains, sustainable competitive advantage, and innovation types to enrich the collective knowledge of innovation and supply chain management.
THE INFLUENCE OF THE HEIFER GENOTYPE ON THE NUTRITIONAL AND ENERGY VALUE OF MUSCLE TISSUE
Authors: Косилов В.И. , Миронова И.В. , Гудыменко В.В. , Долженкова Г.М. , Миронова Е.П. 
Published: November 2023

В статье приводятся результаты изучения химического состава и энергетической ценности мышечной ткани чистопородных тёлок чёрно-пёстрой породы и её помесей первого и второго поколения с голштинами. При проведении контрольного убоя тёлок в 18-месячном возрасте установлено, что помесный молодняк превосходил чистопородных сверстниц по содержанию сухого вещества длиннейшей мышцы спины на 0,88–1,89%, массовой доле экстрагируемого жира – на 0,33–0,66%, протеина – на 0,53–1,18% при практически равном уровне минеральных веществ. При этом чистопородные тёлки уступали помесным сверстницам по содержанию сухого вещества в мышечной ткани туши на 3,76–6,69 кг (10,39–18,50%), массе белка – на 2,80–4,92 (9,32–16,38%), массе экстрагируемого жира – на 0,83–1,53 кг (18,20–33,55%), концентрации энергии в 1 кг мышечной ткани – на 219,47–455,65 кДж (4,80–9,96%), энергетической ценности мышечной ткани туши – на 80,33–144,00 МДж (11,59–20,77%). Преимущество по всем анализируемым показателям было на стороне помесных тёлок второго поколения.
The article presents the results of studying the chemical composition and energy value of the muscle tissue of purebred heifers of the Black-and-White breed and its crossbreeds of the first and second generation with Holsteins. During the control slaughter of heifers at the age of 18 months, it was found that crossbred young stock exceeded purebred herdmates in the dry matter content of the longest back muscle by 0.88–1.89%, the mass fraction of extracted fat – by 0.33–0.66%, protein – by 0.53–1.18% with an almost equal level of mineral substances. At the same time, purebred heifers were inferior to their crossbred herdmates in terms of dry matter content in the muscle tissue of the carcass – by 3.76–6.69 kg (10.39–18.50%), protein weight – by 2.80–4.92 (9.32–16.38%), the mass of extracted fat – by 0.83–1.53 kg (18.20–33.55%), energy concentration in 1 kg of muscle tissue – by 219.47–455.65 kJ (4.80–9.96%), the energy value of the muscle tissue of the carcass – by 80.33–144.00 MJ (11.59–20.77%). The advantage in all analyzed indicators was on the side of crossbred heifers of the second generation.
Analisis Antioksidan Senyawa Bioaktif Ekstrak Lidah Buaya Secara Insilico
Authors: Br Siagian Dos D. L. E. , Kepel Billy J. , Manampiring Aaltje , Bodhi Widdhi , Fatimawali Fatimawali , Budiarso Fona D.H. 
Published: November 2023

Abstract: Aloe vera (Aloe vera L.) is a functional plant that is often found and has a wide range of health advantages. Antioxidants are chemical molecules that inhibit free radicals in the body, which can cause disease by generating oxidation events that destroy cell structure and function. The goal of this research is to see how bioactive chemicals from the aloe vera plant (Aloe vera L.) interact with antioxidant activity. The molecular docking method is combined with insilico analysis in this study, which employs four key applications: autodock tools, autodock vina, biovia discovery studio, and open babel. All amino acid residues in the bioactive compound Aloe vera (Aloe vera L.) act on the active site of the Human endothelial nitric oxide synthase (4D1O) receptor, according to the findings of this study. The binding energi of bioactive substances from aloe vera skin extract (Aloe vera L.) to the 4D1O receptor yielded promising results. Conclusion: Aloe vera (Aloe vera L.) extract bioactive component possesses antioxidant activity, which can particularly reduce or prevent free radical generation in the body.
Keywords: Aloe vera (Aloe vera L.); Antioxidant; Human endothelial nitric oxide synthase (4D1O) receptor; Insilico.
Abstrak: Lidah Buaya (Aloe vera L.) merupakan tanaman fungsional yang umum ditemui dan memiliki banyak manfaat bagi kesehatan. Antioksidan adalah senyawa kimia penghambat radikal bebas di dalam tubuh yang dapat menghambat terjadinya reaksi oksidasi dalam tubuh yang dapat merusak struktur dan fungsi sel sehingga menimbulkan penyakit. Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa bioaktif dari tanaman lidah buaya (Aloe vera L.) terhadap aktivitas antioksidan. Penelitian ini menggunakan metode molecular docking dengan analisis secara insilico yang menggunakan 4 aplikasi utama: autodock tools, autodock vina, biovia discovery studio, dan open babel. Hasil penelitian ini menunjukkan bahwa semua residu asam amino pada senyawa bioaktif Lidah buaya (Aloe vera L.) bekerja pada sisi aktif reseptor Human endothelial nitric oxide synthase (4D1O). Hasil binding energi senyawa bioaktif ekstrak kulit lidah buaya (Aloe vera L.) terhadap reseptor 4D1O menunjukkan nilai yang bagus. Simpulan: Senyawa bioaktif ekstrak Lidah buaya (Aloe vera L.) memiliki aktivitas antioksidan yaitu secara spesifik dapat menekan atau menghambat aktivitas pembentukan radikal bebas di dalam tubuh.
Kata kunci: Lidah buaya (Aloe vera L.); Antioksidan; reseptor Human endothelial nitric oxide synthase (4D1O); Insilico.
PENINGKATAN KETERAMPILAN PERHITUNGAN HARGA POKOK PRODUKSI UNTUK UMKM KELOLAAN MAHASISWA “MOKO”
Authors: Damayanti Ameilia , Ichwani Tia , Munira Mira , Musta`ani Salis , Kurniawati Dewi , Astuti Tri 
Published: November 2023

UMKM merupakan tulang punggung bagi perekonomian Indonesia. Berbagai literatur menyebutkan adanya UMKM pada saat krisis merupakan salah satu penyebab pulihnya kondisi perekonomian. Salah satu sektor usaha yang terus mengalami pertumbuhan seiring dengan bertambahnya jumlah penduduk adalah saktor usaha Food dan Beverage (F&B). Pengabdian ini dilakukan untuk peningkatan pengetahuan serta pemahaman khususnya pada pelaku UMKM yang berasal dari lingkungan FEBUP yaitu mahasiswa yang memiliki usaha agar bisa mengidentifikasi semua biaya yang timbul untuk memperoleh bahan baku ataupun produk dan memproduksinya. Metode pelaksanaan Pengabdian kepada Masyarakat ini menggunakan metode penyuluhan dan pembimbingan oleh tim Pengabdian kepada Masyarakat. Hasil dari kegiatan pengabdian ini adalah pelaku usaha dapat memahami dan menerapkan metode penentuan harga pokok produksi yang paling tepat untuk usahanya.