bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of hemoadsorption in cardiac surgery – a systematic review
Authors: Matejic-Spasic Marijana , Lindstedt Sandra , Lebreton Guillaume , Dzemali Omer , Suwalski Piotr , Folliguet Thierry , Geidel Stephan , Klautz Robert J.M. , Baufreton Christophe , Livi Ugolino , Gunaydin Serdar , Deliargyris Efthymios N. , Wendt Daniel , Thielmann Matthias 
Published: January 2024

Abstract
Background
Despite advancements, cardiopulmonary bypass-assisted cardiac surgery still carries a significant risk for morbidity and mortality, often related to postoperative hyperinflammation. Hemoadsorption of cytokines and various exogenous and endogenous inflammation triggers has been increasingly used in cardiac surgery to mitigate the risk of inflammation-mediated complications. Clinical evidence so far has not provided definite answers concerning this adjunctive treatment. The current systematic review aimed to assess the role of perioperative hemoadsorption in cardiac surgery critically.
Methods
A PubMed literature search with predefined criteria was conducted. The screening and selection process followed rigorous scientific principles (PRISMA statement). The search resulted in 29 publications that were grouped and descriptively analyzed due to the remarkable variability in study designs, however, they all reported exclusively on CytoSorb® therapy.
Results
CytoSorb® use was proven feasible and safe with no unanticipated device-related adverse events reported in the retrieved articles. The most frequently reported clinical outcome associated with hemoadsorption was reduced vasopressor demand resulting in better hemodynamic stability.
Conclusions
The role of hemoadsorption in cardiac surgery seems to be justified in selected high-risk cases in infective endocarditis, aortic surgery, heart transplantation, and emergency surgery of patients under antithrombotic therapy, as well as in those who develop a dysregulated inflammatory response, vasoplegia, or septic shock postoperatively. Current evidence suggests limited value from CytoSorb® use in routine elective surgery and low-risk patients. Further evaluation in more extensive prospective trials is required concerning proper patient selection and postoperative timing and administration.
Associations of demographic characteristics with cognition, prevalence, and control of CVD risk factors and prevalence of CVD among adult Chinese: a population-based study
Authors: Yuan Li , Yuyang Chen , bifang Mai , Ke Xia , Haiyang Xie , Danying Guo , Wenqing Tu , SL Xie 
Published: January 2024

Abstract

Background
The associations of demographic characteristics with cognition, prevalence, and control of cardiovascular disease (CVD) risk factors, and prevalence of CVD, are essential for informed targeted interventions and preventive measures. However, limited knowledge exists regarding these associations. This population-based study aims to investigate these associations among adult Chinese individuals.
Methods
A cross-sectional analysis was conducted on 2,851 participants (mean age 44 years, 50.82% women) using data from the China Heart Rescue Global Evaluation Baseline Household survey. Data was collected using stratified random sampling and computer-assisted personal interviews. The χ2 test and Poisson regression modeling were employed to assess the differences and associations of demographic characteristics with CVD risk factors particulars (including cognition, prevalence, and control) and CVD prevalence.
Results
Although females exhibited higher cognition regarding certain risk factors, both genders demonstrated a high prevalence of CVD. Elderly individuals (≥ 60 years) had a higher prevalence of CVD risk factors and CVD, with notable control of hyperlipidemia (PR: 1.23, CI: 1.05–1.45, adjusted for sex). Higher educational attainment was associated with increased cognition of risk factors and decreased CVD prevalence. Divorced or widowed individuals displayed a higher prevalence of CVD risk factors and CVD (PR: 3.63, CI: 1.00-13.14, after adjusting sex and age).
Conclusion
Sex, age, educational level, and marital status were tightly associated with cognition, prevalence, and control of CVD risk factors, as well as CVD prevalence, among adult Chinese individuals. These findings highlight the importance of considering demographic factors in understanding and addressing cardiovascular health disparities.
Natural Radioactivity, its Health Implications in Natural Spring Water and Soil Mass Attenuation Coefficient Variation along with the Altitude Gradient: A Case Study from a Tourist Hub in Outer Himalayas
Authors: Anjum Mavia , Siddique Naila , Younis Hannan , Zaman Ali , Ahmad Mushtaq , Faiz Yasir , Shafique Munib Ahmed , Anjum Mahnoor 
Published: January 2024

Abstract
Murree, called ‘Queen of Mountains’, is a tourist attraction situated at the foothill of (outer) Himalaya. This study assesses the radionuclide concentration in the natural spring water of Murree and the variation of mass-attenuation coefficient in soil with altitude. For this study, 20 natural springs were selected for water sampling while soil samples were collected from 15 sites employing random sampling. The average radionuclide concentration of Radium-226, Thorium-232, and Potassium-40 were 0.43 ± 0.09, 0.52 ± 0.08, and 1.52 ± 0.19 Bq/L respectively. The radionuclide concentration in Murree’s water is above average as compared to the natural radionuclide concentration in spring water worldwide. The radiation hazard indices namely Radium equivalent (Raeq), external and internal hazard index (Hin & Hex), Indoor and outdoor dose (Din & Dout), annual indoor and outdoor effective dose (Eout & Ein), and lifetime cancer risk (LCR) were quantified. The mean values of Raeq, Hex, Hin, Dout, Din, Eout, Ein, LCRout and LCRin are 1.26 Bq/L, 0.003, 0.005, 0.564 nGy/h, 1.067 nGy/h, 0.001 mSv/y, 0.005 mSv/y, 0.002 & 0.018 respectively. The radionuclides concentration revealed that Murree’s natural spring water has above average radionuclides activity, but the health hazards are not alarming. The mass attenuation coefficient was quantified for 356, 661, 1173, and 1332 keV energies experimentally using Ba-133, Cs-137 & Co-60 sources and theoretically using XCOM software. The mean value of mass attenuation for 356, 661, 1173, 1332 keV is 0.097, 0.074, 0.057, 0.054 cm2/g respectively. The radiation attenuation parameters like Half value layer (HVL), Tenth value layer (TVL), Mean free path (MFP), and the thickness of soil required to attenuate 99% of the radiation were also calculated. Comparatively, Murree’s soil showed lower attenuation properties as compared to cement, tiles, concrete, and Egyptian soil. To correlate the data statistical tools Principal Component Analysis (PCA) and Pearson’s Correlation were used. To express the data spatially ESRI ARC-GIS was used employing Inverse Distance Weighting Interpolation (IDW).
The Relation between Cigarette Smoking and Development of Sepsis: A 10-year Follow-up Study of Four Million Adults from the National Health Screening Program
Authors: Lee Eun Hwa , Lee Kyoung Hwa , Lee Kyu-na , Park Yebin , Han Kyung Do , Han Sang Hoon 
Published: January 2024

Abstract

Background
Sepsis remains a growing global health concern with soaring mortality and no direct anti-sepsis drug. Although smoking has distinct deleterious effects on chronic inflammatory illnesses and can impair immune function, a comprehensive analysis of the connection between sepsis and smoking is lacking.
Methods
This large-scale longitudinal cohort study retrospectively assessed adults aged ≥ 20 years who underwent national health checkups under the Korean National Health Insurance Service between January and December 2009 (N = 4,234,415) and were followed up for 10 years. Sepsis was identified based on the International Classification of Diseases, 10th Revision codes, and smoking status, including accumulated amount, was collected through a self-administered questionnaire. The Cox proportional hazard regression model was used, adjusting for age, sex, household income, body mass index, drinking, exercise, diabetes, hypertension, dyslipidemia, and chronic renal disease.
Results
After excluding cases with sepsis occurring before follow-up or after ≤ 1 year of follow-up, 3,881,958 participants, including non-smokers (N = 2,342,841), former smokers (N = 539,850), and active smokers (N = 999,267) were included. Compared to non-smokers, all active smokers (adjust hazard ratio: 1.41, 95% confidence interval: 1.38–1.44) and former smokers (1.10, 1.07–1.14) with ≥ 20 pack-years exhibited a significantly higher risk of sepsis (p < 0.001). Smoking of ≥ 30 pack-years in former and active smokers groups significantly increased sepsis incidence (adjust hazard ratio [95% confidence interval]: 1.34 [1.31–1.38], p < 0.001).
Conclusions
Smoking is closely associated with the incidence of sepsis. Smoking cessation may help in the primary prevention of sepsis.
The association between periconceptual maternal dietary patterns and miscarriage risk in women with recurrent miscarriages: a multicentre cohort study
Authors: Chung Yealin , Melo Pedro , Easter Christina , Price Malcolm , Dhillon-Smith Rima , Quenby Siobhan , Devall Adam , Coomarasamy Arri 
Published: January 2024

Abstract
In a prospective multicentre cohort study across three UK university hospital research centres, we evaluated the association between periconceptual maternal dietary patterns and miscarriage risk among 1,035 women with recurrent miscarriages. Recurrent miscarriage was defined as 2 or more spontaneous pregnancy losses before 24 weeks. We used a 10-item Food Frequency Questionnaire and the analysis adjusted for maternal confounders and paternal dietary patterns. High consumption of fruit and nuts (almonds and walnuts) was strongly associated with lower miscarriage risk (for fruit the relative risk [RR] was 0.69, 95% confidence interval [CI] 0.54 to 0.89, p = 0.004; for nuts RR 0.73, 95% CI 0.54 to 0.98, p = 0.039). High red meat intake was associated with an 86% increase in miscarriage risk (RR 1.86, 95% CI 1.10 to 3.16, p = 0.022). The association with miscarriage risk was unclear for other food groups, including fresh vegetables, white meat, fish, dairy, eggs, soya, and chocolate, due to imprecise point estimates. This study concludes that a maternal diet rich in fruits and nuts, but low in red meat, is associated with a lower miscarriage risk in women with a history of recurrent miscarriages.
Through-Polymer Via Technology-Enabled Flexible, Lightweight, and Integrated Device for Implantable Neural Probes
Authors: Sun Liuyang , Zhou Cunkai , Tian Ye , Li Gen , Ye Yifei , Gao Lusha , Li Jiazhi , Liu Ziwei , Su Haoyang , Lu Yunxiao , Li Meng , Zhou Zhitao , Wei Xiaoling , Qin Lunming , Tao Tiger 
Published: January 2024

Abstract
In implantable electrophysiological recording systems, the headstage typically consists of neural probes interfacing with brain tissue and integrated circuit chips for signal processing. Although advancements in MEMS and CMOS technology have significantly improved these components, their connection still relies heavily on conventional printed circuit boards and sophisticated adapters. This traditional approach adds considerable weight and volume, especially as channel counts increase. To address this, we have developed a Through-Polymer Via (TPV) method, inspired by the Through-Silicon Via (TSV) technique in advanced three-dimensional packaging. This innovation enables the vertical integration of flexible probes, amplifier chips, and PCBs, culminating in the creation of a Flexible, Lightweight, and Integrated Device (FLID). The total weight of FLID is only 25% of that of conventional counterparts using adapters, which significantly enhances animal activity levels, nearly matching those of control animals without implants. Furthermore, by incorporating a platinum-iridium alloy as the top layer material for electrical contacts, the FLID demonstrates exceptional electrical performance, enabling in vivo measurements of both local field potentials and individual neuron action potentials. Our findings not only showcase the potential of the FLID in scaling up implantable neural recording systems but also mark a significant step forward in the field of neurotechnology.
Modeling the Performance of a Single Rotor Row in a Turbomolecular Pump Using the TPMC Method: Effects of Operational and Geometric Variables
Authors: Sereshgi Maryam Hosseinzadeh , Ebrahimi Reza 
Published: January 2024

Abstract

Turbo-molecular pumps are widely used in industries and scientific studies in areas such as semiconductors and sedimentation. In; such pumps, the influence of the geometric characteristics and operating conditions on performance is of interest to researchers. A single-row rotor of a turbo-molecular pump was simulated, and the test particle Monte Carlo method was used to investigate the effects of blade spacing, angle, number, and length; as well as operating conditions on performance. The maximum compression ratio and pumping speed were calculated. The pump’s performance was studied for 12, 24, 36, and 48 blades in a single-row rotor at angles of 15, 20, and 30 degrees with a clearance of 0.015. We were increasing the gap from 0.015 to 0.025 and 0.035 examined across rotors with 12 to 48 blades, a blade speed ratio of 3.5, and a blade angle of 15 degrees. To validate the results, the numerical values obtained for 36 blades, 30-degree blade angle, and 0.015 clearance were compared to available experimental results, yielding good agreement. The results of this simulation are intended to cover cases of interest for design calculations.
Impacts of Meteorological Parameters on COVID-19 Transmission Trends in the Central Part of Thailand
Authors: Pongpiachan Siwatt , Hirisajja Jayakrit , Aekakkararungroj Aekkapol , Gupta Pawan , Rungsiyanon Siwaporn , Choochuay Chomsri , Deelaman Woranuch , Poshyachinda Saran 
Published: January 2024

Abstract
Several nonpharmaceutical intervention protocols in the form of lockdowns were officially enforced across Thailand to exigently decrease the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the outbreak of COVID-19 disease. A massive contraction of Thailand’s economic activities changed its influences on air pollutants, especially nitrogen dioxide (NO2) and ozone (O3). To elucidate these alterations, we investigate the data from 31 continuous ambient air quality observatory stations in the central part of Thailand from 12 January 2020 to 30 April 2022. Negative correlation coefficients between PM2.5 and O3 in ambient air ranged from -0.35 to -0.71, which can be attributed to the opposing effects of these two air pollutants. While O3 is principally generated by photochemical reactions in the presence of NOx and VOC, PM2.5 can absorb and scatter solar radiation, leading to the inhibition of O3 formation. In addition, multiple linear regression analysis underlined the importance of O3 as the main air pollutant affecting the enhancement of COVID-19 infection rates.
Distinct clinical features of transplanted children with Parvovirus B19 infection
Authors: jia ran , cao lingfeng , lu lijuan , zhong huaqing , xu menghua , liu pengcheng , zhu xunhua , su liyun , xu jin 
Published: January 2024

Abstract

Background
The immature and suppressed immune response makes transplanted children a special susceptible group to Parvovirus B19 (PVB19). However, the clinical features of transplanted children with PVB19 infection hasn’t been comprehensively described.
Methods
We searched the medical records of all the transplant recipients who attended the Children’s Hospital of Fudan University from 1 Oct 2020 to 31 May 2023, and reviewed the medical literature for PVB19 infection cases among transplanted children.
Results
10 cases of PVB19 infection were identified in 201 transplanted children at our hospital, and the medical records of each of these cases were shown. Moreover, we retrieved 40 cases of PVB19 infection among transplanted children from the literature, thus summarizing a total of 50 unique cases of PVB19 infection. The median time to the first positive PVB19 DNA detection was 14 weeks post-transplantation. PVB19 IgM and IgG were detected in merely 26% and 24% of the children, respectively. The incidence of graft loss/dysfunction was as high as 36%. Hematopoietic stem cell transplant (HSCT) recipients showed higher PVB19 load, lower HGB level, greater platelet damage, lower PVB19 IgM/IgG positive rates, and more graft dysfunction than solid-organ transplant (SOT) recipients, indicating a more incompetent immune system.
Conclusions
Compared with the published data of transplanted adults, transplanted children displayed distinct clinical features upon PVB19 infection, including lower PVB19 IgM/IgG positive rates, more graft dysfunction, and broader damage on hematopoietic cell lines, which was even more prominent in HSCT recipients, thus should be of greater concern.
Support mechanical response analysis and surrounding rock pressure calculation method for a shallow-buried super- large-section tunnel in weak surrounding rock
Authors: Lai Haixiang , Wang Xiuying , Tan Zhongsheng , Zhao Jinpeng , Liu Xiabing 
Published: January 2024

Abstract

At present, China's demand for high-speed railway construction is constantly increasing, and the construction of Multi line high-speed railway tunnels has been put on the agenda. The design and construction issues of super-large-sections tunnels urgently need to be addressed. The Xiabei mountain No.1 and No.2 tunnels in the Hangzhou-Taizhou Railway are typical shallow-buried super-large-section-tunnels in weak surrounding rock, and their design and construction issues are representative. Eleven monitoring sections were set up in the tunnel, including tunnel deformation, surrounding rock, shotcrete, steel frames, bolts and temporary support mechanical responses. Taking the monitoring data of the most typical cross-section as an example, the mechanical response of the support structure of a shallow-buried super-large-section tunnel was analyzed in detail. Based on previous research results, this paper discusses and summarizes the common construction problems of this type of tunnel, and puts forward corresponding suggestions. The existing formula for calculating surrounding rock pressure has poor applicability to super-large-section tunnels constructed by step excavation, resulting in conservative support parameters. Therefore, based on the monitoring values of surrounding rock pressure at 10 monitoring sections in Xiabei mountain No. 1 and No.2 tunnels, empirical parameters reflecting the impact of step excavation were summarized. Based on the Wang formula and combined with the step excavation empirical parameters, an empirical formula for the surrounding rock pressure of shallow-buried super-large-section tunnels considering step excavation was constructed. The calculated results are in good agreement with the on-site monitoring data. This study can provide a good reference for similar projects.
Injectable Bombyx mori (B.mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage
Authors: Yang Zhangze , You Yuxin , Liu Xiangyu , Wan Quan , Xu Zongpu , Shuai Yajun , Wang Jie , Guo Tingbiao , Hu Jiaqi , Lv Junhui , Zhang Meng , Yang Mingying , Mao Chuanbin , Yang Shuxu 
Published: January 2024

Abstract
Brain damage is a common tissue damage caused by trauma or diseases, which can be life-threatening. Stem cell implantation is an emerging strategy treating brain damage. The stem cell is commonly embedded in a matrix material for implantation, which protects stem cell and induces cell differentiation. Cell differentiation induction by this material is decisive in the effectiveness of this treatment strategy. In this work, we present an injectable fibroin/MXene conductive hydrogel as stem cell carrier, which further enables in-vivo electrical stimulation upon stem cells implanted into damaged brain tissue. Cell differentiation characterization of stem cell showed high effectiveness of electrical stimulation in this system, which is comparable to pure conductive membrane. Axon growth density of the newly differentiated neurons increased by 290% and axon length by 320%. In addition, unfavored astrocyte differentiation is minimized. The therapeutic effect of this system is proved through traumatic brain injury model on rats. Combined with in vivo electrical stimulation, cavities formation is reduced after traumatic brain injury, and rat motor function recovery is significantly promoted.
Multi-platform whole genome sequencing for tuberculosis clinical and surveillance applications
Authors: Thorpe Joseph , Sawaengdee Waritta , Ward Daniel , Campos Monica , Wichukchinda Nuanjun , Chaiyasirinroje Boonchai , Thanraka Aungkana , Chumpol Jaluporn , Phelan Jody E. , Campino Susana , Mahasirimongkol Surakameth , Clark Taane G. 
Published: January 2024

Abstract
Whole genome sequencing of Mycobacterium tuberculosis offers valuable insights for tuberculosis (TB) control. High throughput platforms like Illumina and Oxford Nanopore Technology (ONT) are increasingly used globally, although ONT is known for higher error rates and is less established for genomic studies. Here we present a study comparing the sequencing outputs of both Illumina and ONT platforms, analysing DNA from 59 clinical isolates in highly endemic tuberculosis regions of Thailand. The resulting sequence data were used to profile the M. tuberculosis for their strain-type, drug resistance and presence in transmission chains, and compared to publicly available whole genome sequences from Thailand (n = 1,456). Our results revealed predominantly lineages 1 and 2 strain-types, with consistent drug resistance profiles, including six multidrug-resistant strains, however, ONT showed longer phylogenetic branches, emphasising its higher error rate. Analysis incorporating the larger dataset identified fifteen of our samples within six potential transmission clusters, including a significant clade of 41 multi-drug resistant isolates. ONT's extended sequences also revealed strain-specific structural variants in pe/ppe genes (e.g. ppe50), candidates for vaccine development. Despite limitations, ONT sequencing is promising for tuberculosis genomic research, supporting precision medicine and decision-making in areas with less developed infrastructure, crucial for tackling the disease’s significant regional burden.