bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSOCIATION OF TROPONINS WITH SEX HORMONES IN STABLE HEMODIALYSIS PATIENTS
Authors: Mohammed Dereen , Ibrahim Terza 
Published: December 2023

Background Cardiovascular events are one of the major causes of death in dialysis. Usually, troponins are regarded gold standard for detecting cardiovascular complications. In addition, studies have confirmed a difference between men and women regarding cardiovascular and renal diseases.
Objectives To investigate the relation between troponins (Hs-TnT) and biomarkers, including sex hormone binding globulin (SHBG), estradiol, total and free testosterone, ferritin, Albumin, CRP and estimated glomerular filtration rate (eGFR) in hemodialysis.
Patients and MethodsSixty-one hemodialysis patients were enrolled in this study. Hs-cTnT, cTnI, total testosterone, free testosterone, SHBG, estradiol, Albumin, CRP, ferritin, urea and creatinine were estimated.
ResultsHs-cTnT was associated with Albumin (R=-0.3; P=0.01). Troponin showed no association with the rest of the markers. The mean values in the dialysis group were: Hs-cTnT 93.8 pg/ml; ferritin 222.1 µg/l; albumin 4.18 g/dl; CRP 18.4 mg/l; urea 143.3 mg/dl; creatinine 9.4 mg/dl; total testosterone 1.46 ng/ml; free testosterone 28.75 pg/ml when compared to the control group, the differences between serum values in dialysis group were significant P < 0.05. The rest of the biomarkers showed no significant differences.
ConclusionThe most interesting finding was a negative association of Albumin with Hs-cTnT, indicating the possible use of albumin-adjusted Hs-cTnT rather than troponin alone to better predict critical cardiac events in hemodialysis. Troponin did not associate with SHBG, estradiol and testosterone hormones, possibly indicating no obvious role of these hormones in troponin regulation. Estimated GFR levels showed no correlation, suggesting troponin might be further degraded before renal elimination.
SURVIVAL OUTCOMES AMONG PATIENTS WITH HIGH-GRADE GLIOMA: A SINGLE INSTITUTION RETROSPECTIVE STUDY
Authors: Gharib Hawbir , Nadhim Ari , Muhsin Bamo 
Published: December 2023

BackgroundThe prognosis for glioma patients is poor, despite recent advances in diagnosis and treatment. Understanding Glioma’s clinical characteristics and predictive factors is crucial for patient treatment and management.
ObjectivesTo assess the survival duration of HGG patients at a single facility and to discover clinical determinants of treatment outcome in HGG treated with a combined modality approach in Zhianawa Cancer Center.
Patients and MethodsThis study included 133 patients with high-grade gliomas diagnosed between January 2015 and January 2020; these patients were referred to the Zhianawa Cancer Center. A retrospective analysis of the clinical data included survival outcomes, tumour characteristics, and demographic information. While the Cox regression model was used for the evaluation of multivariate data to look at the risk factors for mortality, on the other hand, survival data were analyzed using Kaplan-Meier curves with a log-rank test.
ResultsIn this particular patient cohort, grade IV glioma (83.9%), grade III glioma (16.1), and glioblastoma (81.4%) were the most common pathological types. A poor prognosis was associated with not using temozolomide, having a Karnofsky Performance Score (KPS) of less than 70%, and not receiving radiotherapy. Univariate analysis showed low KPS (70) to increase the risk of mortality. Patients who had radiotherapy with normal fractionation, concurrent chemotherapy, and radiotherapy adjuvant chemotherapy had the highest overall survival rates.
ConclusionMortality was significantly related to aging, absence of seizures, presence of motor alteration, pathological grade IV gliosarcoma, glioblastoma multiform, and non-standard radiation dose.
ASSESSING THE ACCURACY OF FIB-4 SCORES TO POINT SHEAR WAVE ELASTOGRAPHY IN MONITORING DIFFERENT STAGES OF FIBROSIS IN NON-ALCOHOLIC LIVER DISEASE
Authors: Rasul Shahla 
Published: December 2023

BackgroundNon-alcoholic liver disease (NAFLD) assessment is done by measuring biochemical parameters from blood samples. However, non-invasive methods have gained significance lately. Biochemical parameters and staging of fibrosis-associated NAFLD based on the levels of biomarkers have been established procedures in the field. So, the utilization of non-invasive methods as a comparable means for fibrosis staging in NAFLD has yet to be established.
ObjectivesTo compare the diagnostic performance of serum markers to point shear wave elastography for classifying fibrosis in NAFLD and its staging.
Materials and MethodsData were collected by laboratory tests and point shear wave elastography. A comparison of FIB-4 indexes scores and point shear wave elastography for the staging of fibrosis in NAFLD was made based on cross-tabulation of the quantitative data obtained.
ResultsA positive and significant correlation between FIB4 and age, ALT, AST, RBS, AST/ ALT, AST/ UL AST, APRI, AST/ Platelet count, and point shear wave elastography (PSWE). The correlation was negative and non-significant between FIB4 and Weight, Height, BMI, UL AST, TSB, and Platelet count.
ConclusionThe study observed a positive correlation between FIB-4 and PSWE. Thus, the present study proposes the use of PSWE as a non-invasive diagnostic tool in the staging of fibrosis in NAFLD for patients with an intermediate FIB-4 score.
Riesgo psicosocial del estrés percibido por docentes de la carrera de Medicina
Authors: Vallejo Hernández Pedro , Morocho Malla Manuel Ismael , Charry Ramirez Jose Ricardo 
Published: December 2023

Introducción: El estrés existe desde el inicio de la humanidad, generado como respuesta a las adversidades, este promovió la supervivencia del ser humano, permitiendo reaccionar a la humanidad ante los peligros constantes. Desde inicios de la medicina, se afirma que ciertas emociones súbitas o causadas por frustraciones prolongadas, podrían provocar enfermedades o empeorarlas, por ello es importante saber identificarlas.
Objetivo: identificar el riesgo psicosocial relacionado al estrés en docentes universitarios de la Carrera de Medicina de la Universidad de Cuenca, Ecuador, en el periodo Marzo – agosto 2021
Método: observacional. Se aplicó un cuestionario para recoger las variables mencionadas, además del Cuestionario SUCESO/ISTAS/21 versión breve, se tomó en cuenta el total de la población docente de la Carrera de Medicina de la Universidad de Cuenca en el periodo lectivo Marzo – agosto de 2021, conformada por 130 docentes.
Resultados: se encontró una frecuencia elevada de riesgo alto en la dimensión “doble presencia” con 48.5%, y en escala global con un 35,6%. Con respecto a las variables demográficas, en mayores a 55 años tienen menos de la mitad de probabilidad de presentar este tipo de riesgo, OR=0,38 (I.C.95%: 0,159-0,911; p=0,027). además, existe asociación estadísticamente significativa (p = 0,043) entre el tiempo laborando como docente, y el riesgo psicosocial alto.
Conclusión: Existe riesgo psicosocial alto, principalmente en dimensión “doble presencia” demostrando mayor cantidad de riesgo a comparación de otras profesiones, estudiadas en las mismas dimensiones a nivel nacional.
Miembros Independientes en las Juntas Directivas en Colombia: Caso Gilinski y Grupo Empresarial Antioqueño
Authors: Ovalle Bejarano Camilo Eduardo 
Published: December 2023

Desde finales de 2021, las funciones y la responsabilidad de los miembros independientes en las juntas directivas de las sociedades cotizadas captaron la atención de la comunidad jurídica y empresarial en Colombia. Entre el 10 de noviembre de 2021 hasta el 18 de noviembre de 2022 el Grupo Gilinski y el Grupo IHC de Abu Dabi a través de las sociedades JGDB Holding S.A.S., Nugil S.A.S e IHC Capital Holding LLC., presentaron ocho ofertas públicas de adquisición sobre las acciones de Grupo de Inversiones Suramericana S.A., Grupo Nutresa S.A. y Grupo Argos S.A., sociedades anónimas que pertenecen a lo que se conoce como el Grupo Empresarial Antioqueño (GEA).
El presente documento realiza un diagnóstico sobre la independencia de los miembros de las juntas directivas de las sociedades cotizadas en Colombia. El estudio se fundamenta en las decisiones que tomaron estos cuerpos colegiados en las sociedades del GEA al valorar la posibilidad de aceptar los términos de las ofertas presentadas por el Grupo Gilinski entre 2021 y 2022.
Paresia de MSE em puérpera após parto normal
Authors: Coral Juana , Machado Moretti Leticia , Corrêa de Oliveira Isabela 
Published: December 2023

Neuropraxias pós-parto das extremidades são possíveis complicações após o parto, com uma incidência estimada de 0,3-2%. Existem alguns relatos de casos sobre paresias em membro inferior após parto vaginal normal. No entanto, uma neuropraxia em membro superior após o parto vaginal normal não foi relatada até o momento. Este é um relato de caso de uma mulher de 30 anos, primigesta e hígida, que visitou o departamento de emergência obstétrica devido bolsa rota com início de trabalho de parto (na idade gestacional de 35 + 6 semanas). Após o parto vaginal normal que ocorreu sem intercorrências com uma hora e cinquenta de período expulsivo, em que a parturiente realizou muita força em membro superior esquerdo para manter posição confortável durante o parto. No dia seguinte a paciente referiu paresia, edema ++/++++ e sensibilidade alterada em bordo ulnar e dorso do polegar do MSE. Após avaliação ortopédica com solicitação RM de coluna cervical, evidenciou-se degeneração de C3-C4 e osteofitose. Concluiu-se então tratar-se de Neuropraxia por Estiramento. Optou-se por consulta conservadora bem como acompanhamento com ortopedista. Após 2 meses, a paciente já havia recuperado parcialmente força e sensibilidade no MSE e recuperação completamente após 3 meses. Em conclusão, a neuropraxia de membro superior pode ocorrer após o parto vaginal normal, mesmo sem complicações perinatais. A neuropraxia por estiramento no caso apresentado obteve um bom prognóstico.
APRENDIZADOS ENTRE PRÁTICA E TEORIA NO PROJETO DE EXTENSÃO
Authors: De Oliveira Murilo , França Ferreira Jaqueline , Luiz Vieira Jorge , Regina Marchesan Gláucia , Regina Baumer Édina 
Published: December 2023

RESUMO
O presente artigo tem como objetivo socializar a dupla experiência entre a prática e a teoria de um grupo de bolsistas dos cursos de Pedagogia e Arquitetura e Urbanismo que participaram do projeto de extensão “Com Olhos de Criança: análise dos espaços e das relações no Complexo Educacional Bairro da Juventude pelas crianças dos anos iniciais do Ensino Fundamental” da Universidade do Extremo Sul Catarinense (UNESC). O contato com as crianças no campo de atuação e a busca por um referencial teórico que desse maior sentido para o projeto, modificou a forma como o grupo de discentes olhava para as crianças e a cidade, rompendo concepções “adultocêntricas” e acolhendo uma nova forma de pensar o desenvolvimento das infâncias. A prática aconteceu no Bairro da Juventude, escola que recebe diariamente crianças de todos os bairros de Criciúma que vivem em estado de vulnerabilidade social. A teoria fundamentou-se nas leituras de algumas obras do professor Francesco Tonucci, que ao discutir a relação entre infância e cidade, deu sentido a tudo aquilo que foi realizado na prática. Ambas as experiências geraram o resultado desse artigo: um grupo de futuros profissionais sensíveis aos apelos das infâncias. Logo, esse texto apresenta a importância da união entre prática e teoria para a boa formação daqueles que estão envolvidos em projetos de pesquisa e extensão.
Palavras-chave: Práxis. Extensão. Infância. Cidade. Protagonismo.

ABSTRACT
This article aims to socialize the double experience between the practice and theory of a group of scholarship holders of the Pedagogy and Architecture and Urbanism courses that participated in the extension project "With Eyes of Children: analysis of spaces and relationships in the Youth Neighborhood Educational Complex by children in the early years of elementary school" of the University of the Extreme South of Santa Catarina (UNESC). The contact with children in the field of action and the search for a theoretical framework that gave greater meaning to the project, modified the way the group of students looked at children and the city, breaking "adultcentric" conceptions and welcoming a new way of thinking about the development of childhood. The practice happened in Bairro da Juventude, a school that receives daily children from all neighborhoods of Criciúma who live in a state of social vulnerability. The theory was based on the readings of some works of teacher Francesco Tonucci, who when discussing the relationship between childhood and city, gave meaning to everything that was accomplished in practice. Both experiences generated the result of this article: a group of future professionals sensitive to the appeals of childhood. Therefore, this text presents the importance of the union between practice and theory for the good formation of those who are involved in research and extension projects.
Keyword: Praxis. Extension. Childhood. City. Protagonism.
QUINTA DO CHÁ : TROCA DE SABERES SOBRE PLANTAS MEDICINAIS NA ATENÇÃO PRIMÁRIA À SAÚDE, 4 edição
Authors: Rossato Angela , Dal Bó Silva , Luciano Mônica Pavei , Pizzolotto Alice Jacques , Coral Jadna Silveira Rosso , Cemin Gabriela Peraro , Citadini-Zanette Vanilde 
Published: December 2023

O projeto Quinta do Chá - troca de saberes sobre plantas medicinais na atenção primária à saúde, é desenvolvido pelo GEPAF/UNESC em parceria com a Secretaria Municipal de Saúde de Urussanga. Objetiva promover uso seguro das plantas medicinais através da troca de saberes/conhecimentos sobre fitoterapia, fornecendo subsídios para implantá-la na Atenção Básica. A metodologia utilizada divide-se em cinco fases, Fase 1: Diagnóstica; Fase 2: Pesquisa dos aspectos botânicos, agroecológicos e terapêuticos das espécies vegetais. Fase 3: Encontros mensais, denominados de Quinta do Chá, onde são compartilhadas as informações coletadas na Fase 2. Fase 4: Dados científicos e populares são sistematizados e na Fase 5: Implantação da Horta Terapêutica. No ano de 2022, doze espécies medicinais foram apresentadas e, neste artigo, vamos abordar quatro delas, sendo três validadas como fitoterápico e uma considerada como PANC (Plantas Alimentícias Não Convencionais). Consideramos que o projeto teve êxito em Urussanga devido à participação ativa do poder municipal, dos profissionais envolvidos e da comunidade nas atividades realizadas, bem como pela instalação da Horta de Plantas Medicinais e Aromáticas, localizada próximo à Unidade Básica da região central do município, que está sendo mantida e financiada pela gestão municipal. As atividades oferecidas pelo projeto permitem a reintrodução de conhecimentos e práticas ancestrais de saúde, promoção do autocuidado e a integração de saberes populares, tradicionais e científicos em prol de uma terapia emancipatória, solidária e ecológica. Ademais, o projeto aproxima a universidade da comunidade, transformando cenários e currículos, além de formar futuros profissionais para a prática da fitoterapia.
linguagem teatral na formação do estudante
Authors: Bieberbach Luiz Gustavo , De Souza Honorato Aurélia Regina , Vieira Mantovani Dariane Vieira Mantovani , De Souza João Victória 
Published: December 2023

O presente artigo caracteriza-se como um Relato de Experiência a partir das atividades do projeto de extensão intitulado A linguagem teatral como formadora na comunicação verbal e corporal dos estudantes, realizadas durante os anos de 2021 e 2022. Bolsistas do Curso de graduação em Teatro, acompanhadas por seu professor orientador, desenvolveram, junto a estudantes do Ensino Médio do Colégio Unesc – Universidade do Extremo Sul Catarinense, técnicas teatrais para o aperfeiçoamento da comunicação verbal e corporal dos jovens, futuros sujeitos emancipados, que, a partir das experiências tenham possibilidades de aprimorar o convívio e as relações em sociedade. As atividades prático-teóricas desenvolvidas foram embasadas nas pesquisas de Augusto Boal, Jerzy Grotowski, Viola Spolin, entre outros. A experiência do projeto se mostrou um desafio para as bolsistas e para os estudantes, pois a linguagem do teatro exige movimento e transformação.
Palavras-chave: Colégio Unesc; Linguagem teatral; Ensino médio.
Relación entre la discapacidad en locomoción y en comunicación y la escolaridad en pacientes con parálisis cerebral
Authors: Rodriguez Ramirez María , Najarro-De La Cruz Tany , Fajardo-Campos Pedro 
Published: December 2023

Objetivo: Identificar la relación entre la severidad de la discapacidad en locomoción y en comunicación y la escolaridad en pacientes con parálisis cerebral. Material y métodos: Estudio transversal y retrospectivo en 316 pacientes con parálisis cerebral entre los 3 y 12 años, atendidos entre julio del 2016 y junio del 2017 en el Instituto Nacional de Rehabilitación "Dra. Adriana Rebaza Flores" AMISTAD PERU-JAPÓN, Lima-Perú. Resultados: La edad promedio fue 6 años (rango de 3 a 12 años), 57% del sexo masculino. La parálisis cerebral espástica representó el 69,7% seguida por la discinética en 20,9%. El 69,6% estaba escolarizado y más del 50% presentó discapacidad severa en locomoción y comunicación. Se encontró una relación inversa entre la severidad de la discapacidad en locomoción y en comunicación y la escolaridad. Conclusiones: Los niños con parálisis cerebral que presentan una mayor severidad de la discapacidad en locomoción y comunicación, tienen una menor asistencia a la escuela.
Analysis of the quality indicators of electricity supply services on the example of the distribution system operator JSC "Kharkivoblenergo"
Authors: Cherkashyna Veronika , Yakovenko Oleh 
Published: December 2023

The resolution of the National Commission in 2021 for the operator of the distribution system JSC “Kharkivoblenergo”, which operates in the territory of the city of Kharkiv and the Kharkiv region, established a tariff for electricity distribution services with the application of incentive regulation, which provides for tariff formation on the basis of long-term regulation of tariffs and adjustment of the necessary income of the Company based on the performance of the task of achieving the target values of the quality indicators of electric energy and compliance with the guaranteed standards. In accordance with this Resolution, the indicators of the quality of services System Average Interruption Duration Index (SAIDI) and System Average Interruption Frequency Index (SAIFI) for the supply of electric energy were analysed using the example of the operator of the distribution system JSC “Kharkivoblenergo”. The SAIDI quality indicator is characterized by the duration of long interruptions in electricity supply in the distribution system of JSC “Kharkivoblenergo”. The SAIFI quality indicator provides information on the frequency of long interruptions in electricity supply in the distribution system of JSC “Kharkivoblenergo”. The analysis of SAIDI and SAIFI indicators was performed for the short-term period of operation of the operator of the distribution system JSC “Kharkivoblenergo”, namely for December 2021. Based on the results of the analysis of SAIDI and SAIFI indicators, it follows that the achievement of the target values of quality indicators allows adjusting the necessary rate of income for the operator of the distribution system JSC “Kharkivoblenergo”, and also creates a favourable investment climate, which ensures modernization, reconstruction and construction for the renewal of the energy infrastructure with the aim of improving the quality of providing services for the supply of electric energy to consumers. Also, the analysis of the indicated indicators made it possible to evaluate the work of JSC “Kharkivoblenergo” in terms of the implementation of established quality indicators, to identify problem areas in the Company's activities regarding the provision of guaranteed quality standards, to form and practically implement an investment program, to determine how quality indicators are reflected in tariff formation in the incentive regulation.
Mechanism of the first and second peaks in epinephrine pharmacokinetics over time
Authors: Lockey Richard F. , Ellis Anne K. , Lowenthal Richard , Tanimoto Sarina 
Published: December 2023

Abstract
Background: There is a documented double peak phenomenon following the intramuscular injection of epinephrine, however these peaks are typically representative of mean epinephrine concentrations and not individual subjects.
Objective: An examination of epinephrine pharmacokinetics was conducted to explore the nature of the double peak phenomenon and to determine if the double peaks observed in mean concentration profiles were also observed in individual subjects.
Methods: A GCP compliant study was conducted in 36 adult volunteers with a history of type I allergies. Blood samples were collected before and at multiple timepoints after subjects self- administered two FDA-approved epinephrine auto-injectors (EpiPen 0.3 mg and Symjepi 0.3 mg). Pharmacokinetic parameters (Cmax and tmax) and concentration-time curves were determined based on individual subjects. Subjects were categorized by their tmax (≤4 min, >4 min - ≤10 min, >10 min - ≤20 min, >20 min - ≤30 min, >30 min - ≤45 min, and >45 min, presented as ≤4 min, ≤10 min, ≤20 min, ≤30 min, ≤45 min, and >45 min, respectively).
Results: The majority of individual subjects did not have double peaks. Double peaks in mean concentration-time profiles were observed when tmax was ≤4 min following EpiPen and Symjepi, tmax ≤30 min following EpiPen, and tmax ≤45 min following EpiPen. The individual epinephrine concentration curves for subjects with a tmax ≤4 min following EpiPen and Symjepi and tmax ≤45 min following EpiPen demonstrate that the majority of individual subjects do not have double peaks.
Conclusion: These data suggest that the double peaks observed in mean epinephrine concentrations are likely driven by subsets of subjects with either early or late tmax values and may not necessarily be a pharmacokinetic characteristic of epinephrine.