bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encapsulating Polyoxometalates inside Single‐Walled Carbon Nanotubes for Efficient Solar‐Driven Interfacial Evaporation
Authors: Cui Ziwei , Wu Jianfei , Zhou Chengxu , Ai Shiyan , Zhou Hui , Kang Fangyuan , Huang Qing , Kang Lixing , Zhang Qichun , Tian Dan 
Published: January 2025

AbstractPolyoxometalates (POMs) display great potential for application in the photothermal field. However, the high water‐solubility of POMs restricts their use for solar‐driven interfacial evaporation. Therefore, controlling the stability of POMs and fully utilizing their photothermal characteristics is a challenge. Hence, a strategy is proposed through confining POMs with single‐walled carbon nanotubes (SWCNTs), which serve as a photothermal layer of a metal‐organic frameworks‐modified wood evaporator for solar steam generation. POMs are effectively protected by SWCNTs, and concurrently narrow the bandgap of SWCNTs to increase light absorption. Furthermore, the molecular dynamics simulations indicate that the metal‐organic frameworks in wood substrate can lower the enthalpy of evaporation by regulating microenvironment of hydrogen bonds. With this ingenious design, the evaporation rate reaches 2.53 kg m−2 h−1 under 1 sun, which exceeds most wood‐based evaporators. Meanwhile, the evaporator also exhibits good purification performance for seawater and wastewater. This work provides precise regulation from the molecular level, and can be extended to create more efficient solar evaporators.
Co0 and CoOx Nanoclusters Encapsulated in Carbon Microspheres for the Low‐Temperature Enhanced Reduction of NOx by CO
Authors: Zhang Xinyu , Wang Yixi , Xu Wenqing , Jia Lihua , Su Fabing , Zhu Tingyu 
Published: January 2025

AbstractEfficient low‐temperature NO reduction by transition metal‐based catalysts remains a significant challenge. In this study, a Co‐based catalyst, Co0+CoOx@CS, encapsulated by carbon microspheres and synthesized via a one‐step in situ hydrothermal method, exhibits excellent NO conversion, exceeding 99% at 150 °C. X‐ray Absorption Fine Structure analysis reveals electronic interactions between C and Co, anchoring Co0 nanoclusters to the carbon microspheres. The resulting microporous structure enhances reactant accessibility and facilitates N─O bond cleavage. Furthermore, C13O isotopic tracing experiments reveal that NO reduction follows an ONNO pathway, in which adsorbed CO induces the dissociation of ONNO* to ONN*, and weakly adsorbed or gaseous CO promotes further decomposition of ONN* to N2. Specifically, Co0 species enhance NO adsorption, while CoOx species favor CO adsorption, with oxygen vacancy‐mediated oxygen transfer driving the catalytic cycle. This study presents a novel approach for preparing microporous Co‐based catalysts and offers an effective strategy for efficient low‐temperature NO reduction.
Hierarchical DNA Octahedral Nanoplatform for in Situ Biosensing and Clinical Monitoring of Acute Lymphoblastic Leukemia
Authors: Liu Qian , Shen Man , Xu Hanqing , Wang Jingxue , Wang Ruoding , Xiao Ting , Wang Shuang , Chen Jiao , Liu Lu , Zhang Ligai , Zhou Yang , Wu Xianlan , Huang Yingchun , Ren Zhangyin , Bao Jing , Chen Ming , Gao Mingxuan 
Published: January 2025

AbstractDeveloping nanoscale platforms with high integration, assembly efficiency, and structural stability for performing complex computations in specific cells remains a significant challenge. To address this, the Three‐dimensional Hierarchical Octahedral Robotic (THOR) DNA nanoplatform is introduced, which integrates targeting, logic computation, and sensing modules within a single framework. This nanoplatform specifically binds to cancer cell surface proteins, releasing aptamer‐linked fuel chains to initiate subsequent computational processes. Three logic gates efficiently compute any arbitrary binary combination of target proteins. The sensing module employs catalytic hairpin assembly for detecting specific miRNAs with high sensitivity. THOR demonstrates robust functionality both in vitro and in situ. As a proof‐of‐concept, this nanoplatform to distinguish acute lymphoblastic leukemia (ALL) patients from other leukemia subtypes and healthy participants, achieving 100% accuracy is applied. Additionally, this approach reliably monitored the therapeutic progress of ALL patients, showing strong concordance with bone marrow smear results. The THOR platform highlights the feasibility of constructing a reliable, hierarchical, and multifunctional analytical system based on a single DNA polyhedron. It offers a promising auxiliary tool for clinical diagnostics and therapeutic monitoring.
Efficient Spin‐Light‐Emitting Diodes With Tunable Red to Near‐Infrared Emission at Room Temperature
Authors: Yao Jingwen , Huang Yuling , Sun Haifeng , Wang Zhiyu , Xue Jie , Huang Zhifeng , Dong Shou‐Cheng , Chen Xihan , Lu Haipeng 
Published: January 2025

AbstractSpin light‐emitting diodes (spin‐LEDs) are important for spin‐based electronic circuits as they convert the carrier spin information to optical polarization. Recently, chiral‐induced spin selectivity (CISS) has emerged as a new paradigm to enable spin‐LED as it does not require any magnetic components and operates at room temperature. However, CISS‐enabled spin‐LED with tunable wavelengths ranging from red to near‐infrared (NIR) has yet to be demonstrated. Here, chiral quasi‐2D perovskites are developed to fabricate efficient spin‐LEDs with tunable wavelengths from red to NIR region by tuning the halide composition. The optimized chiral perovskite films exhibit efficient circularly polarized luminescence from 675 to 788 nm, with a photoluminescence quantum yield (PLQY) exceeding 86% and a dissymmetry factor (glum) ranging from 8.5 × 10−3 to 2.6 × 10−2. More importantly, direct circularly polarized electroluminescence (CPEL) is achieved at room temperature in spin‐LEDs. This work demonstrated efficient red and NIR spin‐LEDs with the highest external quantum efficiency (EQE) reaching 12.4% and the electroluminescence (EL) dissymmetry factors (gEL) ranging from 3.7 × 10−3 to 1.48 × 10−2 at room temperature. The composition‐dependent CPEL performance is further attributed to the prolonged spin lifetime as revealed by ultrafast transient absorption spectroscopy.
Spray‐Assisted Fabrication of Cellulose Photonic Pigments on Superhydrophobic Surfaces
Authors: Song Jianing , Parker Richard M. , Frka‐Petesic Bruno , Deng Tao , Xu Luqing , Deng Xu , Vignolini Silvia , Shen Qingchen 
Published: January 2025

AbstractPhotonic pigments, especially those based on naturally‐derived building blocks like cellulose nanocrystals (CNCs), are emerging as a promising sustainable alternative to absorption‐based colorants. However, the proposed manufacturing methods for CNC pigments, via either grinding films or emulsion‐based production, usually require several processing steps. This limits their commercialization by increasing the costs, timescales, and environmental impacts of production. Toward addressing these challenges, it is reported that photonic pigments can be produced in a single process by drying microdroplets of aqueous CNC suspension on a superhydrophobic surface. Such liquid‐repellent substrate ensures the microdroplets maintain a near‐spherical shape, enabling the radial self‐organization of the cholesteric phase. Upon drying under ambient conditions, the CNC mesophase becomes kinetically arrested, after which the strong capillary forces induced by water evaporation result in extensive buckling of the microparticle. This buckling, coupled with prior tuning of the CNC formulation, enables photonic pigments with adjustable color across the visible spectrum. Importantly, the elimination of an emulsifying oil phase to create microdroplets enables a much faster drying time (≈40 min) and improved color stability (e.g., polar solvents, elevated temperatures), while the reduction in reagents (e.g., oils, surfactants) and post‐processing steps (e.g., solvent, heat) improves the sustainability of the fabrication process.
The Critical Role of Atomic‐Scale Polarization in Transition Metal Oxides on Vanadium‐Redox Electrochemistry
Authors: Zhang Xiangyang , Ao Kelong , Shi Jihong , Yue Xian , Valencia Agnes , Shi Xingyi , Zhou Weijun , Liu Fei , Li Weilu , Daoud Walid A. 
Published: January 2025

AbstractTransition metal oxide electrocatalysts (TMOEs) are poised to revive grid‐scale all‐vanadium redox flow batteries (VRFBs) due to their low‐cost and unique electronic properties, while often inescapably harboring surface vacancies. The role of local vacancy‐induced physicochemical properties on vanadium‐redox electrochemistry (VRE), encompassing kinetics, and stability, remains profoundly unveiled. Herein, for the first time, it is revealed that vacancies induce atomic‐scale polarization in TMOEs and elucidate its mechanism in VRE. Attributable to local polarization, particularly by cation vacancy, the activated nearest‐coordinated Mn sites prominently augment the adsorption competence of the V2+/V3+ couple and expedite its round‐tripping by forming an intermediate *Mn–O–V bridge. It is also affirmed that the anion vacancies are vulnerable to microstructure reconfiguration by feeble hydroxyl adsorption and thus performance degradation over long‐term cycling, in contrast to cation vacancies. Accordingly, the VRFB employing cation‐vacancy‐functionalized electrode delivers an energy efficiency of 80.8% and a reliable 1000‐cycle lifespan with a negligible decay of 0.57% per cycle at 300 mA cm−2, outclassing others. The findings shed light on the fundamental rules governing the utility and evolution of vacancies in TMOEs, thereby moving a step closer toward their deployment in a wide range of sustainable energy storage schemes.
Toward Personalized Stationary Chromatography Phases: Equipping Commercial Silica Phases with Selected Peptide‐Based Binding Domains to Tailor Affinity
Authors: Busche Steffen A. , Bangert Lukas D. , Brand Raoul D. , Kröger Tommy , Heyl Enrico , Börner Hans G. 
Published: January 2025

AbstractA set of peptide‐functionalized mesoporous silica particles is synthesized by chemoselective inverse electron‐demand Diels‐Alder (IEDDA) ligation, exploiting the robust and cost‐effective norbornene/tetrazine coupling chemistry. The peptides program the capabilities of the silica particles to specifically complex and host small organic entities. Customized chromatography columns are packed that are tailored to specifically retard the respective compounds, while other substances elute rapidly. Using combinatorial means, the 7‐mer peptides QFFLFFQ, QFFEFFQ, and QFQQSFF have been previously selected as good, medium, and poor binders, respectively, for the photosensitizer 5,10,15,20‐tetrakis(3‐hydroxyphenyl)chlorin (m‐THPC). These sequences are C‐terminally functionalized with 1,2,4,5‐tetrazine (Tz) moieties to enable IEDDA ligation to silica material presenting endo‐ /exo‐norbornene (Nb) moieties to give pyridazine (Pz)‐linkages. The resulting silica‐Pz‐Peptide materials (Sil‐Pz‐X) retain their pore systems and show peptide loadings of up to 0.19 mmol g−1. The capabilities of the different Sil‐Pz‐X materials to bind the photosensitizer are investigated by incubation/elution batch assays, confirming that the peptides define the binding selectivity and capacity in a sequence‐dependent manner. Professional packing of Sil‐Pz‐X results in a set of high‐performance liquid chromatography (HPLC) columns. HPLC elution studies of m‐THPC and a functional relative, Chlorin E6, show a compound‐specific retardation that clearly reflects the complexation properties of the peptides for the respective photosensitizers.
Subcellular Cavitation Bubbles Induce Cellular Mechanolysis and Collective Wound Healing in Ultrasound‐Inflicted Cell Ablation
Authors: Bai Ziyue , Li Zaimeng , Shao Yue 
Published: January 2025

AbstractFocused ultrasound (FUS) has been widely adopted in medical and life science researches. Although various physical and biological effects of FUS have been well‐documented, there is still a lack of understanding and direct evidence on the biological mechanism of therapeutic cell ablation caused by high‐intensity ultrasound (HIFU) and the subsequent wound healing responses. This study develops an enclosed cell culture device that synergistically combines non‐invasive FUS stimulation and real‐time, on‐the‐fly live‐cell imaging, providing an in vitro platform to explore short and long‐term biological effects of ultrasound. The process, mechanism, and wound healing response of cell ablation induced by HIFU are elucidated, revealing a unique mechanism, termed ultrasound‐inflicted cellular mechanolysis, that is mediated by growing subcellular cavitation air bubbles under confined contact with cells. This provides a previously unappreciated mechanism for understanding the biomechanical principles of ultrasound‐based ablative therapy. A post‐ablation phantom layer is also revealed that serves as a guiding cue for collective cell migration during wound healing, thereby providing a biomimetic model for studying wound healing after HIFU‐inflicted damage. Together, this study provides theoretical and technological basis for advancing the understanding of the biological effects of ultrasound‐based ablative therapy and inspiring clinically relevant applications in the future.
α‐Lipoic Acid Ameliorates Arsenic‐Induced Lipid Disorders by Promoting Peroxisomal β‐Oxidation and Reducing Lipophagy in Chicken Hepatocyte
Authors: Zhao Yangfei , Guo Mingyue , Pei Ting , Shang Chenqi , Chen Yirong , Zhao Liying , Lu Yiguang , Liang Chen , Wang Jundong , Zhang Jianhai 
Published: January 2025

AbstractLiver disease poses a significant threat to global public health, with arsenic (As) recognized as a major environmental toxin contributing to liver injury. However, the specific mechanisms and the protective effects of α‐lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology and network pharmacology to comprehensively analyze the hepatotoxic mechanism of As and the hepatoprotective mechanism of LA, and further verifies the mechanisms of peroxisomal β‐oxidation and lipophagy in the process. The network analysis results show that As induces liver damage mainly through autophagy, apoptosis, lipid metabolism, and oxidative stress, whereas LA exerts its hepatoprotective properties mainly by regulating lipid metabolism. Further verifications find that As inhibits SIRT1 expression, activates the P53 and Notch pathways, damages mitochondria, inhibits peroxisomal β‐oxidation, increases lipid accumulation, and enhances lipophagy in the liver, while LA intervention alleviates As‐induced lipid accumulation and enhances lipophagy by targeting SIRT1, ameliorating mitochondrial damage, enhancing peroxisomal β‐oxidation, thereby alleviating As‐induced liver damage. This study further clarifies the mechanism of As hepatotoxicity and provides a theoretical basis for LA as a potential hepatoprotective agent.
Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer
Authors: Qin Tingting , Wang Jingya , Wang Jian , Du Qingwu , Wang Liuchun , Liu Hailin , Liu Wenting , Li Xueyang , Jiang Yantao , Xu Qi , Yu Junjie , Liu Huiyan , Wang Ting , Li Mengjie , Huang Dingzhi 
Published: January 2025

AbstractImmunotherapy has gained approval for use in small cell lung cancer (SCLC), yet only a subset of patients (10–20%) experience meaningful benefits, underscoring the urgent need for more effective therapeutic approaches. This work discovers a distinct HDAC7‐high SCLC phenotype characterized by enhanced proliferative potential, which recurs across various subtypes and serves as a predictor of poorer survival outcomes. By analyzing public datasets, this work finds a strong correlation between c‐Myc and HDAC7. RNA sequencing and cellular experiments show that XPO1 is a key regulator in the HDAC7/c‐Myc axis. HDAC7 promotes β‐catenin deacetylation, phosphorylation modulation, nuclear translocation, and formation of the β‐catenin/TCF/LEF1 complex, which binds to c‐Myc and XPO1 promoters. Activation of the HDAC7/β‐catenin pathway upregulates c‐Myc and XPO1 expression, while c‐Myc also boosts XPO1 expression. Given the difficulty in targeting c‐Myc directly, this work tests selinexor and vorinostat in SCLC xenograft models, with selinexor showing superior results. High HDAC7 expression is linked to increased SCLC proliferation, poorer prognosis, and enhanced sensitivity to selinexor in SCLC cell lines and organoid models. Collectively, this work uncovers a novel HDAC7/c‐Myc/XPO1 signaling axis that promotes SCLC progression, suggesting that HDAC7 may warrant further investigation as a potential biomarker for assessing selinexor sensitivity in SCLC patients.
Photothermal‐Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy
Authors: Yu Fei , Zhao Xuan , Wang Qian , Niu Yifei , Xiao Peng , Zhang Jinze , Fei Keyi , Huang Yuancong , Liu Liu , Fang Po‐Han , Du Xinyue , Li Weihua , He Dalian , Zhang Tingting , Li Saiqun , Yuan Jin 
Published: January 2025

AbstractMeibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease, presenting a challenge for targeted treatment. Traditional topical ocular drug delivery methods often fail to effectively reach the meibomian glands (MGs). To address this, the study has developed a soluble microneedles (MN) patch comprising poly(vinyl alcohol), cyclodextrin modified polyacrylic acid, and new indocyanine green. This innovative MN patch facilitates the transdermal release of peroxisome proliferator‐activated receptor gamma (PPAR‐γ) agonists, such as rosiglitazone in response to near‐infrared ray induced temperature changes. By safely optimizing temperature, the patch effectively liquefied meibum lips, thereby alleviating duct obstruction while releasing the drug. MN patches exhibit sufficient mechanical strength for effective skin penetration, and its biosafety for eyelid application has been rigorously assessed in vitro and in vivo. The therapeutic efficiency of rosiglitazone loaded MN (ROSI‐MN) treatment for MGD is evaluated in high‐fat mice. After three months of treatments, ROSI‐MN administration significantly alleviated MGD clinical manifestations, including ocular surface damage, lipid deposits, glandular hypertrophy, and inflammatory infiltration, ultimately improving the microstructure and biofunction of MGs. In conclusion, the soluble MN patches hold promise as an effective drug delivery strategy for treating ocular surface diseases beyond MGD.
Innovation and water productivity: Empirical evidence from water‐related patents
Authors: Nyiwul Linus , Hu Zhining , Koirala Niraj P. 
Published: January 2025

AbstractThis paper investigates the impact of innovation in the water sector on water productivity using a global sample of 81 countries from 2000 to 2019. We derive theoretical parameters in the Cobb–Douglas production framework and estimate these parameters using fixed‐effects panel instrumental variable and system generalized method of moments estimations. Contrary to theoretical predictions, we find that water‐related innovation has a significant negative effect on water productivity. This suggests the presence of a productivity paradox in the water sector. In our analysis, this paradox is consistent across various modeling specifications and alternative estimations, marking a unique phenomenon not previously observed outside the information and communication technologies sector. Furthermore, the paradox is more pronounced in countries of the global north compared with those in the global south, a divergence we attribute to differences in economic structures, technological capabilities, and resource allocations. These findings underscore the complexity of the role water‐related innovation plays in water productivity and highlight the need for tailored approaches to address region‐specific challenges.
Thermo‐Rheological Performance Evaluation of GNPs‐WO3/Engine Oil Hybrid Nanofluids During Laminar Flow Inside a Horizontal Tube
Authors: Ghalehkhondabi Vahab , Fazlali Alireza , Sadeghi Ali , Hekmatiyan Abbas 
Published: January 2025

ABSTRACTIn the present study, to improve the rheological behavior and heat transfer characteristics of engine oil, nanolubricants were prepared by suspension of graphene nanoparticles (GNPs) (2–8 nm) and tungsten trioxide (WO3) (23–65 nm) in working fluid using a two‐step approach. The nanoengine oil had good stability and dispersibility without agglomeration phenomenon. The influences of adding NPs to the base fluid on the dynamic viscosity and shear stress for different shear rates at room temperature were studied. The nanofluid viscosity increased with the increase of the weight fraction of NPs, and the same concentration decreased with the increase in shear rate. Three theoretical models have been developed for predicting the rheological behavior of nanofluids. The curve fitting of the shear stress–shear rate shows that the relationship between them is linear at all weight fractions of NPs, so the nanofluids have Newtonian behavior. The effects of Reynolds number and NPs weight fraction (0.2, 0.4, 0.8, and 1.2 wt.%) on the convective heat transfer coefficient and pressure drop of GNPs‐WO3/engine oil hybrid nanofluids in a horizontal circular tube under laminar flow condition were investigated experimentally. The enhancement of convective heat transfer coefficient and Nusselt number were found to increase concerning NPs weight fraction and Reynolds number up to 140.8% and 95.2%, respectively. According to the features expressed for the proposed hybrid nanofluid, it can be applied in different areas of lubrication and heat transfer.
Training Future Teachers to Conduct Trial‐Based Functional Analyses Using Virtual Video Modeling and Video Feedback
Authors: Sorrell Jasmine R. , Stratton Kasee K. , Bates‐Brantley Kayla , Wildmon Mark E. 
Published: January 2025

ABSTRACTStudents commonly engage in problem behaviors, yet teachers report handling difficult behavior as their biggest challenge. Over the last few decades, some research has used functional analyses (FAs) to determine the function of student's problem behavior and then developed function‐based interventions based on the FA findings. Despite the success of the studies, research has indicated that traditional FA methodologies are not always feasible for teachers and schools. Therefore, a need exists to develop better and more efficient ways to train teachers to conduct FAs. Thus, the study aimed to evaluate the effectiveness of using virtual video models to train future teachers to conduct trial‐based functional analyses (TBFAs) and assess if the skill could generalize into an in‐person setting. A concurrent multiple baseline design across participants was used, and results indicated that the videos effectively taught participants to conduct a TBFA. The virtual training generalized well into an in‐person setting, with only one participant needing additional feedback. Additionally, results indicate that the virtual intervention was socially valid for all participants.