bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of A Mouse Model of Stellate Ganglion Block and Subsequent Biphasic Effects on Bilateral Cerebral Cortical Blood Flow
Authors: Wang Jiahua , Zhou Wei , Wang Xiaohong , Yan Shiting , Yan Shunping , Wang Ying , Yu Yanlong , Li Hu , Zhang Dongsheng , Zhang Zhuan 
Published: October 2023

Background and objectives: Stellate ganglion block (SGB) has significant therapeutic efficacy in various clinical practices and further exploration of SGB is needed. The mouse model of SGB had not been reported and the effect on cerebral cortical blood flow (CCBF) was controversial. We aimed to establish an stellate ganglion block (SGB) mouse model and explore how SGB influences CCBF.
Methods: Male C57BL/6 mice were randomly divided into five groups (n = 6): groups L (left SGB) and R (right SGB) received an injection of 0.25% ropivacaine hydrochloride (0.08 mL) on the respective stellate ganglion; similarly, groups SL (left saline control) and SR (right saline control) received an injection of normal saline (0.08 mL) instead. Group C received no intervention. CCBF was assessed before SGB (T0) and 10 (T1), 30 (T2), 60 (T3), 90 (T4), and 120 min (T5) after SGB using laser speckle contrast imaging system.
Results: The SGB mouse model was successfully established in groups L and R. Compared with baseline, CCBF on the blocked side decreased at T1, increased at T2–T5, and peaked at T3 in groups L and R (all, P < 0.01). Compared with groups C and SL, the CCBF on the left side decreased at T1 and increased at T2–T5 in group L (all, P < 0.05). A similar trend was noted in groups C and SR relative to group R. The CCBF on the unblocked side decreased at T1, increased at T2–T5, and peaked at T3 in groups L and R (all, P < 0.01).
Conclusions: The SGB mouse model was established successfully. Unilateral SGB can affect bilateral cerebral cortical blood flow, which shows a transitory decrease followed by a significant increase for at least 2 h.
Радянські репресивні практики і масовий терор у 1920 ті рр. (на прикладі Поділля)
Authors: Коляструк Ольга 
Published: October 2023

Метою статті є спроба проаналізувати масовий терор як єдино прийнятний для більшовиків спосіб завоювання влади та її збереження. Завдання полягає в осмисленні особливостей терору в Україні та на Поділлі, зокрема. Пропонується розглядати історію радянської окупаційної влади як типову для поведінки переможця стосовно переможеного – «тероризую, бо маю силу і владу, бо можу, не маю обмежень». Методологічною основою дослідження є принципи науковості, історизму, загальнонауковий інструментарій (аналіз, синтез, узагальнення). Аналіз та інтерпретація радянського режиму ґрунтується на цивілізаційно-гуманістичному та соціоантропологічному підходах. Наукова новизна роботи полягає у спробі узагальнити сучасне осмислення радянського режиму як окупаційно-колоніального, який переміг і закріпився завдяки терору і масовим репресіям. В Україні радянська каральна система мала геноцидальний характер і була спрямована проти селянства і національно свідомих категорій суспільства. Висновки. Радянська владна система – від збройного захоплення влади у 1917 р. до повалення режиму у 1991 р. – була за своєю ідеологією і політичною діяльністю карально-репресивною по відношенню до суспільства. Вона піддавала насильству різні соціальні верстви і категорії з різною мірою інтенсивності в залежності від особливостей історичного періоду. Безмежне застосування «революційного» насильства до реальних і уявних опонентів і суперників було родовою ознакою радянсько-більшовицької диктатури, цинічно легітимованої як «диктатура пролетаріату». Масовий терор і репресії були сутністю більшовизму в цілому, а не лише інструментом силових структур. Без репресій і терору радянська влада неможлива. Терор мав загальнопоглинальний (тотальний) характер, просякав усі сегменти і сфери суспільного життя і мав неперервний характер. Боротьба з внутрішніми і зовнішніми «ворогами народу» була штучною апологетикою людиноненависницької програми більшовиків.
SPECIFICS OF ANTIBODY GENESIS IN NOVOSIBIRSK BREED SM-1 PIGS IN THE PROCESS OF PHYLOGENESIS
Authors: Efanova N. V. , Batalova S. V. , Osina L. M. , Vdovina G. V. 
Published: October 2023

The article presents data reflecting the features of the synthesis of IgM and IgG in pigs of the SM-1 breed of Novosibirsk selection in phylogenesis. The studies were conducted on pigs on the 30th, 60th, 90th and 240th days of life in 1990, 1996 and 2006. birth. Each group of animals included 66 animals. Groups of animals were formed according to the method of analogues, taking into account age, body weight, sex and health. Pigs were bled from the cranial vena cava. The concentration of IgM and IgG in the blood serum of animals was determined by simple radial immunodiffusion. The study results showed that pigs born in 1990 differ from their peers born in 1996 and 2006 in statistically significant high levels of IgM at 30, 60, and 240 days of age and increased activity of IgG synthesis at three months of age. So, at 30 days of age, piglets born in 1990 exceeded the IgM content in the blood serum of sucklings born in 1996 by 15.5% (P<0.001) and piglets born in 2006 - by 20.0% (P<0.001). On the 60th day of life, the differences between pigs born in 1990 and 1996 and between 1990 and 2006 were, respectively, 26.2 (P<0.01) and 32.5% (P<0.01). In pigs on the 240th day of life, born in 1990, the concentration of IgM in the blood serum was 44.6% (P<0.001) higher than in pigs born in 1996 and 48.0% (P<0.001) higher than in pigs 2006 year of birth. At two months, piglets born in 1990 were inferior in IgG level to piglets born in 1996 by 24.4% and too young animals born in 2006 by 24.7% (P<0.01). A month after weaning, pigs born in 1990 demonstrated the best rehabilitation qualities of the immune system. As a result, piglets born in 1990 were ahead of their counterparts in 1996 and 2006. births by 26.1% (P<0.001) and 26.0% (P<0.001), respectively. Pigs 1996 and 2006 birth throughout the study showed a stable level of antibody genesis.
BIOLOGICAL CONTROL OF RASPBERRY SPUR BLIGHT CAUSED BY <i> DIDYMELLA APPLANATA </i> USING A MIXTURE OF MICROBIAL AGENTS
Authors: Shpatova T. V. , Shternshis M. V. , Kozlova A. S. 
Published: October 2023

The article presents the results of three-year field trials of the mixed experimental bio preparation Phytop 26.82, consisting of the bacteria Bacillus amyloliquefaciens RCIM (All-Russian Collection of Industrial Microorganisms) B 10642, Bacillus licheniformis RCIM (All-Russian Collection of Industrial Microorganisms) B 10562, Bacillus subtilis RCIM (All-Russian Collection of Industrial Microorganisms) Microorganisms) B 10641, nematophagous fungi Arthrobotrys oligospora RCIM (All-Russian Collection of Industrial Microorganisms) F-1141 and Duddingtonia flagrans VKM F-2574, as well as the entomopathogenic fungus Beauveria bassiana, against the central raspberry disease - purple spot in the production plantations of the culture. The concentration of the mixture was 105 CFU/ml. As a comparison, we used the chemical fungicide Topaz, EC (emulsion concentrate) at 0.1% concentration. Previously, the authors evaluated the effect of this microbial mixture on the pathogen Didymella applanata in laboratory conditions, which was the basis of field trials. It was found that when one-year-old raspberry shoots were affected by purple spotting, the treatment of vegetative plants reduced the development of the disease by almost three times for more than a month after applying the microbial mixture. Furthermore, the prevalence of the disease decreased by two times or more relative to the control. The biological efficiency of the experimental bio preparation Phytop 26.82 reached 72.7%, comparable to the Topaz chemical fungicide. This mixed microbiological preparation is promising as an environmentally friendly means of protecting raspberries from purple spotting while suppressing other potential diseases and pests on this crop and reducing the undesirable influence of abiotic environmental factors.
Analisis Minat Beli Pengunjung Terhadap Perkembangan Produk Industri Pariwisata Kreatif Sulaman Ambun Suri Bukittinggi
Authors: Wandira Nency Ayu , Widianita Rika 
Published: October 2023

Penelitian ini di latar belakangi oleh Sulaman Ambun Suri yang masih menggunakan mesih manual untuk proses produksi dan membutuhkan waktu lama. Minat beli anak muda masih sedikit karena harga dan belum mengenal produk Sulaman Ambun Suri sebagai produk industri pariwisata kreatif Bukittinggi. Persaingan pasar yang tinggi membuat minat beli pengunjung lebih memilih perkembangan produk yang di jual di pasaran di bandingkan produk Sulaman Ambun Suri. Dan minat beli pengunjung luar negeri tinggi namun terbatas oleh akses yang menjadi kendala utama dalam pendistribusiannya. Penelitian ini bertujuan untuk mengetahui apakah minat beli pengunjung berpengaruh terhadap perkembangan produk industri pariwisata kreatif Sulaman Ambun Suri Bukittinggi. Jenis penelitian lapangan menggunakan metode kuantitatif. Populasi dalam penelitian ini adalah pengunjung Sulaman Ambun Suri Bukittinggi. Pengambilan data yang digunakan adalah sampling insidental dengan rumus Lemeshow. Sehingga sampel yang digunakan sebanyak 96 responden. Hasil penelitian yang digunakan menunjukkan bahwa variabel minat beli pengunjung (X) berpengaruh secara signifikan terhadap perkembangan produk (Y) industri pariwisata kreatif Sulaman Ambun Suri Bukittinggi dimana kontribusinya 92,6% sedangkan 7,4% sisanya dipengaruhi oleh variabel lainnya. Penemuan ini akan membantu pembeli dalam memahami perkembangan produk di industri pariwisata kreatif. Kata Kunci: Industri Pariwisata Kreatif; Minat Beli Pengunjung; Perkembangan Produk.
In silico analyses of bioactive compounds extracted from ziziphus jujuba using supercritical CO2 extraction: Potential anti-anxiety and anti-Alzheimer’s disease
Authors: Abdulqahar Fadwa W. , Morgab Mohammed A. , Hussein Feryal F. , Apyantseva Yulia , El-Messery Tamer M. 
Published: October 2023

Background: Jujube (Chinese date) is a fruit with a pleasant, sweet taste, traditionally used as sedative to treat insomnia and anxiety. Objective: The study aims to explore the potential of these bioactive compounds in exerting anti-anxiety and anti-Alzheimer's disease effects. Methods: Molecular docking, ADME, and molecular dynamics studies were carried out for the green-extracted phytochemicals against acetylcholinesterase and Beta-amyloid proteins for Anti-Alzheimer’s disease effect and serotonin receptor for anti-anxiety activity. Our results suggest that compound (2,3,6,7-tetramethyl-10-(4-methylphenylsulfonyloxy)-1,4,4.alpha.,5,8,8a.beta.,9.b) showed good binding affinity of -10.3 with acetylcholinesterase (4EY7) as anti-Alzheimer’s disease and the compound andrographolide with serotonin transporter (6VRH) showed binding affinity of -9.7 for anxiety. Compounds with the best docking scores were subjected to molecular dynamic simulations.Results: These compounds revealed the best stability. Conclusion: These findings are promising for manufacturing new functional foods, nutraceuticals, food supplements, and/or pharmaceuticals which may play a good and safe role in treating Alzheimer disease and anxiety. While further biological studies must be carried out, our computational studies suggest that these compounds have potent activity.Keywords: Ziziphus jujuba; Bioactive compounds; Neurological disorders disease; Molecular docking, ADME and Molecular dynamics.
Economic and Other Human Rights Remain Hostages of Oil Companies
Authors: Effoduh Jake Okechukwu 
Published: October 2023

<p>The Niger Delta is one of the ten most important wetland and coastal marine ecosystems in the world and is home to more than thirty-one million people. Its massive oil deposits have been extracted for decades by the government of Nigeria and multinational oil companies. Extracted crude oil has generated more than six hundred billion U.S dollars since the 1960s; but environmental quality and sustainability of the overall wellbeing and development of the region remain a serious concern as more than sixty percent of the people in the region depends on the natural environment for livelihood. The environmental resource base, which is used for agriculture, fishing and the collection of forest products, is the principal source of food. Thus, pollution and environmental damage in the immediate and surrounding areas pose significant risks to economic and other human rights’ issues.</p>
The Economic Development of Nigeria from 1914 to 2014
Authors: Effoduh Jake Okechukwu 
Published: October 2023

<p>There is a common Igbo proverb that says: No elephant is burdened by the weight of its tusks. The current economic problem in our nation is often lamented and cursed as unendurable, as if it is peculiar to the nation alone. Similarly, the fiscal measures introduced by the government are looked upon as hindrances or impediments, which a few may consider as irrelevant and unnecessary impositions. Yet, to look back at our growing up problems as if they are burdens, which we must cast off immediately, or run away from, is to be superficial and incapable of understanding ourselves, an offshoot of our character. The Nigerian economy, whether advancing or otherwise, is the weight that we must bear in our growth towards maturity, and in coming into full being as adults and as a nation. A mother does not complain of the weight of the child she carries on her back. The child is part of the process – the route towards her self-fulfillment.</p>
MAPEAMENTO DA PRODUÇÃO CIENTÍFICA SOBRE PROCESSOS DECISÓRIOS EM PROGRAMAS DE PÓS-GRADUAÇÃO EM ADMINISTRAÇÃO
Authors: Parreira Ingrid Santos , Gomes Jane Henriques Gonçalves Marinho , Campos Rita de Cássia Leal , Araújo Uajará Pessoa 
Published: October 2023

Este artigo teve como objetivo revelar o estado da produção de conhecimento em processos decisórios no Brasil mediante a análise de teses, dissertações e programas de pós-graduação com atuação no campo. Tratou-se de uma pesquisa descritiva, documental (com fonte principal o Coleta Capes), multicasos, transversal (quadriênio Capes 2017 a 2020), com análise de dados por estratificação de 199 teses e dissertações. Observou-se que cada Programa de Pós-Graduação em Administração com linha de pesquisa em Teoria da Decisão – PPGA/TD tem sua linha própria que, em alguns casos, leva as suas teses e dissertações a se afastarem da Tomada de Decisão. Esta pesquisa fornece elementos críticos para o entendimento de como os Programas dedicados a processos e sistemas decisórios conduziram suas pesquisas, além de sinalizar eventuais gaps e oportunidades de investigação. Ademais, é apresentada uma articulação de como examinar a aderência ou aproximação de pesquisas com a Tomada de Decisão.
Palavras-Chave: Processos e sistemas decisórios. Teorias da decisão. Pesquisa científica. Programa de Pós-Graduação. Produção do conhecimento.

Abstract: This article aimed to reveal the state of knowledge production in decision-making processes in Brazil through the analysis of theses, dissertations and graduate programs operating in the field. This was a descriptive, documentary research (with the main source Coleta Capes), multicase, cross-sectional (Capes quadrennium 2017 to 2020), with data analysis by stratification of 199 theses and dissertations. It was observed that each Graduate Program in Business Administration with a line of research in Decision Theory - PPGA/TD has its own line that, in some cases, leads its theses and dissertations to move away from Decision Making. This research provides critical elements for understanding how the Programs dedicated to decision-making processes and systems conducted their research, in addition to signaling possible gaps and opportunities for investigation. In addition, an articulation of how to examine the adherence or approximation of research with Decision Making is presented.
Keywords: Decision-making processes and systems. Decision theories. Scientific research.
UPAYA MENINGKATKAN HASIL BELAJAR IPA MELALUI METODE MIND MAPPING PADA SISWA KELAS VI SD NEGERI TOTOGAN SAMIGALUH
Authors: Diandita Yusuf Nungky , Nisa Ana Fitrotun , Hasanah Daimul 
Published: October 2023

Tujuan penelitian ini untuk mengetahui peningkatan hasil belajar IPA siswa kelas VI SD Negeri Totogan melalui penerapan metode Mind Mapping. Jenis penelitian ini adalah penelitian tindakan kelas dengan subjek penelitian siswa kelas VI SD Negeri Totogan yang berjumlah 24 siswa. Metode pengumpulan data yang digunakan alat ukur tes prestasi belajar fisika pada materi alat optik, dokumentasi, observasi dan wawancara. Penelitian ini menggunakan metode rancangan pretest-posttest design. Teknik analisis yang digunakan dalam penelitian ini adalah uji-t yaitu paired sample t-test dan independent sample t-test. Paired sample t-test digunakan untuk menguji perbedaan rata-rata (mean) antara hasil pre test dan post test pada masing-masing kelompok (kelompok eksperimen dan kelompok kontrol). Data hasil penelitian dianalisis secara deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa pembelajaran melalui penerapan metode Mind Mapping dapat meningkatkan hasil belajar IPA pada siswa kelas VI SD Negeri Totogan. Peningkatan tersebut dapat dilaksanakan melalui modifikasi tindakan berupa; penyampaian materi dengan metode MindMapping yang dimodifikasi, tanya jawab materi dengan melibatkan siswa secaraakif, membuat dan mengkreasikan bentuk Mind Mapping dengan didampingi guru dan peneliti, mempresentasikan hasil Mind Mapping siswa dengan cara memilihnya secara acak, serta melakukan refleksi pembelajaran dengan melibatkan siswa pada akhir pembelajaran. Berdasarkan hasil tes, data hasil belajar menunjukkan bahwa nilai rata-rata pada pratindakan 61,67 dengan ketuntasan belajar 16,7%, meningkat pada siklus I menjadi 66,82 dengan ketuntasan belajar 50%, dan meningkat kembali pada siklus II dengan nilai rata-rata 83,19 dengan ketuntasan belajar 79,2%. Dengan demikian metode Mind Mapping dapat meningkatkan hasil belajar siswa kelas VI SD Negeri Totogan.

Kata kunci: Hasil Belajar, IPA, Mind Mapping
KEANEKARAGAMAN FENOTIPE DAN DAYA DUKUNG LINGKUNGAN PADA AYAM LOKAL DI KECAMATAN MERAWANG KABUPATEN BANGKA
Authors: Irwanto Riko , Marinah  , Shalsabilla Rizqi Aulia Awanni  , Tissya Milly Gusnia  
Published: October 2023

Penelitian ini bertujuan untuk mengetahui keanekaragaman fenotipe dan keadaan daya dukung lingkungan dalam budidaya ayam lokal di Kecamatan Merawang Kabupaten Bangka. Penelitian ini dilaksanakan di 5 desa pada Kecamatan Merawang yang memiliki banyak peternakan yam lokal. Metode pengambilan sampel yang digunakan adalah purposive sampling. Analisis data secara deskriptif terhadap data berat, morfologi dan keadaan kandang. Parameter yang diamati pada penelitian ini adalah pengamatan fenotipe berupa sifat kualitatif (warna bulu, corak bulu, pola bulu, kerlip bulu, warna shark dan tipe jengger) dan sifat kuantitatif (bobot badan ayam, panjang tubuh ayam, lingkar dada ayam, panjang paha atas dan bawah ayam, panjang shank) dan pengukuran parameter lingkungan. Hasil yang diperoleh terdapat 164 ekor ayam lokal. Ayam yang diperoleh terdiri dari 108 ekor ayam betina dan 56 ekor ayam jantan Hasil penelitian menunjukkan bentuk jengger dominan rose (jantan) dan pea (betina), warna bulu putih (jantan) dan berwarna (betina), warna shank kuning, corak bulu baik jantan maupun betina dominan lurik. Pola bulu dominan colombian, sedangkan kerlip bulu dominan emas baik ayam lokal jantan maupun betina. Hasil penelitian menunjukkan bobot badan ayam lokal di lima desa, Ayam lokal Merawang memiliki bobot rata-rata berkisar 12,6 ± 9,33 kg (jantan) dan 192,4 ± 2,87 kg (betina). Sedangkan ukuran panjang tubuh ayam masing-masing untuk jantan dan betina (rata-rata±SD standard deviation) yaitu 1.734 ± 51,53 mm dan 3.091 ± 104,13 mm; panjang shank 306,6 ± 9,78 mm dan 551,8 ± 18,16 mm; panjang paha(femur) 749 ± 28,53 mm dan 1.403 ± 46,74 mm; panjang betis (tibia) 702 ± 17,60 mm dan 1.228 ± 38,29 mm; dan lingkar shank 63,6 ± 1,16 mm dan 121 ± 3,77 mm. Rata-rata suhu lingkungan kandang yaitu 28ºC yang diperoleh dari pengukuran suhu pada pagi, siang dan malam. Faktor lingkungan seperti perkandangan dan suhu menjadi daya dukung budidaya ayam lokal di Bangka.
Kata Kunci: ayam, Bangka, fenotip, Merawang.
Pengembangan Lembar Kerja Siswa (LKS) Berbasis Model Inkuiri Terbimbing Pada Tema Bahaya Air Yang Tercemar Untuk Menumbuhkan Berpikir Kreatif Siswa
Authors: Aprilia Chyntia Wulan , Biru Lulu Tunjung , Resti  Vica Dian Aprelia 
Published: October 2023

Pengembangan Lembar Kerja Siswa (LKS) berbasis model inkuiri terbimbing pada tema bahaya air yang tercemar untuk menumbuhkan berpikir kreatif siswa diawali dengan adanya permasalahan saat wawancara oleh seorang guru IPA bahwa buku paket saja kurang mampu untuk membantu siswa menumbuhkan berpikir kreatif, siswa masih kurang berperan dalam proses pembelajaran. Pengembangan ini adalah LKS yang di dalamnya mengandung langkah-langkah model pembelajaran inkuiri terbimbing terdapat dalam bagian isi LKS yang memuat perumusan masalah, membuat hipotesis, merancang percobaan dengan langkah kerja, melakukan percobaan untuk memperoleh data dan membuat kesimpulan sehingga dapat membantu menumbuhkan kemampuan berpikir kreatif siswa. Penelitian ini merupakan penelitian dan pengembangan (Research & Development) dengan menggunakan model penelitian four-D (4-D) dan desain penelitian modifikasi Thiagarajan karena tahap dissiminate tidak dilakukan. Hasil penelitian menunjukkan bahwa pengembangan lembar kerja siswa berbasis inkuiri terbimbing pada tema bahaya air yang tercemar untuk menumbuhkan berpikir kreatif siswa dilakukan melalui 3 tahapan yaitu tahap pendefinisian (Define), tahap perancangan (Design), dan tahap pengembangan (Develop). Tingkat kevalidan mendapatkan nilai 80% dengan kriteria valid berdasarkan validasi ahli materi dan media berturut-turut dan 85% dengan kriteria sangat valid serta penilaian guru mendapatkan nilai 92% dengan kriteria sangat valid. Berdasarkan hasil uji kevalidan secara keseluruhan maka diperoleh nilai rata-rata 85,6% dengan kriteria sangat valid.

Kata Kunci: Pengembangan LKS; inkuiri terbimbing; bahaya air yang tercemar; berpikir kreatif.