bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEMOCRACIA NOS PARTIDOS POLÍTICOS BRASILEIROS: UM DIAGNÓSTICO
Authors: Vequi Matheus , Demarchi Clovis , Ospina Juan Felipe Orozco 
Published: October 2023

Contextualização: O tema da democracia intrapartidária começa a receber atenção a partir dos estudos de Michels sobre as tendências à oligarquização em grandes associações. Por se configurar como um instrumento de participação popular, o assunto tem despertado maior atenção frente ao atual cenário de crise das instituições democráticas.
Objetivo: Analisar o estágio da democracia intrapartidária nos partidos políticos brasileiros a partir da visão conjunta de estudos que examinam a distribuição do poder interno.
Metodologia: A pesquisa se dividiu em quatro etapas, sendo a primeira delas a investigação e seleção inicial do material com base no referente estipulado. Na segunda etapa, valendo-se do Método Cartesiano, os trabalhos foram analisados e organizados em três eixos temáticos, conforme o objetivo e a problemática de cada pesquisa. A terceira etapa compreendeu a realização de cortes temporais, em virtude da necessidade de fornecer um panorama atual, e materiais, na medida em que os trabalhos foram reanalisados com base no referente e no objetivo proposto, adequando o objeto de análise a partir do método Indutivo. Na quarta etapa operou-se a reanálise das informações coletadas, a compilação dos dados e a exposição dos resultados, com base lógica indutiva.
Resultados: Mais do que uma ausência de democracia intrapartidária, é possível inferir que as agremiações institucionalizaram práticas oligárquicas que permitem a estabilidade das lideranças nos postos de comando. É possível apontar ao menos seis meios facilitadores do domínio das lideranças sobre as decisões e a estrutura da agremiação: são eles: (1) distribuição discricionária dos recursos partidários; (2) convenções partidárias esvaziadas de poder; (3) dissolução arbitrária de órgãos permanentes; (4) eleições indiretas em múltiplos níveis; (5) modelo de disputa em chapas; (6) a existência de órgãos decisórios paralelos.
The effect of ratios upon improving patient-based real-time quality control (PBRTQC) performance
Authors: Li Yuanyuan , Chen Xiaoling , Zhao Ying 
Published: October 2023

Abstract

Objectives
Large biological variation hinders application of patient-based real-time quality control (PBRTQC). The effect of analyte ratios on the ability of PBRTQC to improve error detection was investigated.

Methods
Four single analyte-ratio pairs (alanine aminotransferase [ALT] vs. ALT to aspartate aminotransferase ratio [RALT]; creatinine [Cr] vs. Cr to cystatin C ratio [RCr]; lactate dehydrogenase [LDH] vs. LDH to hydroxybutyrate dehydrogenase ratio [RLDH]; total bilirubin [TB] vs. TB to direct bilirubin ratio [RTB]) were chosen for comparison. Various procedures, including four conventional algorithms (moving average [MA], moving median [MM], exponentially weighted moving average [EWMA] and moving standard deviation [MSD]) were assessed. A new algorithm that monitors the number of defect reports per analytical run (NDR) was also evaluated.

Results
When a single analyte and calculated ratio used the same PBRTQC parameters, fewer samples were needed to detect systematic errors (SE) by taking ratios (p<0.05). Application of ratios in MA, MM and EWMA significantly enhanced their ability to detect SE. The influence of ratio on random error (RE) detection depended upon the analytes and PBRTQC parameters, as consistent advantage was not demonstrated. The NDR method performed well when appropriate parameters were used, but was only effective for unilateral SE. Rearrangement of sample order led to a significant deterioration of conventional algorithms’ performance, while NDR remained almost unaffected.

Conclusions
For analytes with large variation and poor PBRTQC performance, using ratios as PBRTQC indexes may significantly improve performance and achieve better anti-interference ability, providing a new class of monitoring indicators for PBRTQC.
Science and Survival: Exploring the Papers of Georg and Max Bredig
Authors: Shea Patrick H. 
Published: October 2023

Abstract
Following the death of his parents, George Bredig inherited a large steamer trunk inconspicuously tucked away in the basement of his boyhood home in Oak Ridge, Tennessee. The trunk was old, and upon opening it, a strong musty smell emerged from within. As he reviewed the contents of the trunk, he discovered an assortment of unpublished letters, original photographs, rare pamphlets and small scientific artifacts. His father Max and grandfather Georg were both gifted physical chemists and it did not take long for George to realize that these papers documented their scientific careers in the years preceding their flight from Nazi Germany.
A novel travel route planning method based on an ant colony optimization algorithm
Authors: He Shan 
Published: October 2023

Abstract
As people’s living standards improve, tourism has become an important way for people to spend their time on leisure and entertainment. The growing number of tourists in recent years has given rise to the creation of tourism-related ancillary services. Travelers need to choose a travel route that suits their needs and expectations and do it in a way that does not cause a waste of time, whether it is an emerging self-driving tour or a traditional tour group. Therefore, the optimization of tourist routes is of great significance to the majority of tourists. Given the planning requirements of tourist attractions in the post-epidemic era, an ant colony-based optimization algorithm is proposed to resolve the planning problem of optimal tourist routes. An optimized pheromone update strategy is also proposed based on the basic ant colony optimization algorithm. The optimized ant colony algorithm tries to balance two conflicting concepts, namely, flows into tourist attractions and the carrying capacity of destinations. To analyze the performance of the proposed optimization algorithm, the effects of different optimization algorithms on the route planning of tourist attractions were compared in the experiment, and the acceleration ratio of the optimized ant colony algorithm was tested using the graphics processing unit parallel computing program. The results show that the proposed algorithm provides certain advantages and has certain potential in parallel computing. To sum up, this study provides a better scientific basis for optimal tourist route planning and has a good reference value.
The impact of zirconia nanoparticles on the mechanical characteristics of 7075 aluminum alloy
Authors: Al Zubaidi Faten N. , Asaad Lamyaa Mahdi , Alshalal Iqbal , Rasheed Mohammed 
Published: October 2023

Abstract
In numerous engineering applications, metal matrix composites strengthened by ceramic particles have played an important role. For this purpose, an aluminum (Al 7075) nanocomposite has been fabricated, and nano-zirconium oxide of particle size 40 nm (0, 0.8, 1.6, and 2.4) wt% reinforced Al 7075 alloy was produced using a stir-casting process. The effect of ZrO2 NPs loading on mechanical properties along with the detailed characterization were demonstrated. The performance of Al with ZrO2 nanocomposite was investigated by Vickers hardness tester, scanning electron microscopy, energy-dispersive X-ray, compression test, Lee’s disc, and Shore D instruments were utilized to determine the hardness, structural morphology, composition of the elements, Young’s modulus, thermal conductivity, and roughness values of the samples, respectively. The hardness (120.3–177) HV, compression strength (624.2–878.6) MPa, yield modulus (38–70) MPa, surface roughness (0.876–0.606) µm, thermal conductivity (2.0–2.39) W/m2 °C improved by increasing the wt% of ZrO2 NP reinforcement particles. The implication of these findings shows that 5 wt% nano-ZrO2-reinforced Al 7075 composites yielded better performance than pure Al 7075 alloy. To sum up, this investigation demonstrated that the ZrO2 reinforcement enhanced the mechanical properties of Al 7075.
The crystal structure of (E)-4-fluoro-N′-(1-(4-hydroxyphenyl)propylidene)benzohydrazide, C16H15FN2O2
Authors: Wen Juanjuan , Liu Langlang , Tang Wenqiang , Liu Bin 
Published: October 2023

Abstract
C16H15FN2O2, orthorhombic, P212121 (no. 19), a = 7.2516(6) Å, b = 11.3780(9) Å, c = 17.1177(13) Å, V = 1412.36(19) Å3, Z = 4, R

gt
(F) = 0.0498, wR

ref
(F
2) = 0.1201, T = 293 K.
Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury
Authors: Fuentes‐Flores Andrés , Geronimo‐Olvera Cristian , Girardi Karina , Necuñir‐Ibarra David , Patel Sandip Kumar , Bons Joanna , Wright Megan C , Geschwind Daniel , Hoke Ahmet , Gomez‐Sanchez Jose A , Schilling Birgit , Rebolledo Daniela L , Campisi Judith , Court Felipe A 
Published: October 2023

AbstractFollowing peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c‐Jun transcription factor activation. Unfortunately, axonal regeneration is greatly impaired in aged organisms and following chronic denervation, which can lead to poor clinical outcomes. While diminished c‐Jun expression in SCs has been associated with regenerative failure, it is unclear whether the inability to maintain a repair state is associated with the transition into an axonal growth inhibition phenotype. We here find that reparative SCs transition into a senescent phenotype, characterized by diminished c‐Jun expression and secretion of inhibitory factors for axonal regeneration in aging and chronic denervation. In both conditions, the elimination of senescent SCs by systemic senolytic drug treatment or genetic targeting improved nerve regeneration and functional recovery, increased c‐Jun expression and decreased nerve inflammation. This work provides the first characterization of senescent SCs and their influence on axonal regeneration in aging and chronic denervation, opening new avenues for enhancing regeneration and functional recovery after peripheral nerve injuries.
Discrimination of Seismic Events in the North Korean Test Site and Surrounding Area Using MDAC Spectral Ratio
Authors: Ding Shiban , Wang Hongchun , Zhu Haofeng , Xu Henglei , Xu Xiong 
Published: October 2023

ABSTRACT
An event of ML 3.7 occurred near the Punggye-ri nuclear test site on 11 February 2022. It was stronger than the known historical earthquakes around the North Korean test site (NKTS). How to accurately identify whether this event and future events near NKTS are explosions or natural earthquakes is worth paying attention to. For moderate and small earthquakes, the regional P/S spectral ratio has the advantage of identifying explosions and earthquakes. However, the P/S spectral ratio depends on magnitude and ray path. Magnitude and distance amplitude correction (MDAC) was proposed and demonstrated to be an effective method to correct magnitude and path effect. Different from the traditional MDAC method, we use explosions to build the MDAC model to reduce the influence of the source radiation pattern. After building the MDAC model, we analyze the Pg/Lg and Pn/Lg spectral ratios of 6 nuclear tests and 60 earthquakes at the NKTS from 2013 to 2021. The results show that the spectral ratio residuals of the 6 nuclear tests are mainly distributed around 0 after correction, whereas the spectral ratio residuals of earthquakes are obviously &lt;0 above 3 Hz and are clearly distinguished from explosions as expected. The Pg/Lg and Pn/Lg spectral ratios of the ML 3.7 earthquake near the NKTS on 11 February 2022 exhibit similar characteristics to historical natural earthquakes. We further discuss the influence of magnitude on P/S spectral ratios. In the NKTS, the differences in the P/S ratio between earthquakes and explosions are similar before and after magnitude correction at 4–8 Hz. Nevertheless, the magnitude correction increases by ∼27% of the difference between explosions and natural earthquakes at 6–9 Hz to better separate explosions from natural earthquakes.
An Object Storage for Distributed Acoustic Sensing
Authors: Ni Yiyu , Denolle Marine A. , Fatland Rob , Alterman Naomi , Lipovsky Bradley P. , Knuth Friedrich 
Published: October 2023

Abstract
Large-scale processing and dissemination of distributed acoustic sensing (DAS) data are among the greatest computational challenges and opportunities of seismological research today. Current data formats and computing infrastructure are not well-adapted or user-friendly for large-scale processing. We propose an innovative, cloud-native solution for DAS seismology using the MinIO open-source object storage framework. We develop data schema for cloud-optimized data formats—Zarr and TileDB, which we deploy on a local object storage service compatible with the Amazon Web Services (AWS) storage system. We benchmark reading and writing performance for various data schema using canonical use cases in seismology. We test our framework on a local server and AWS. We find much-improved performance in compute time and memory throughout when using TileDB and Zarr compared to the conventional HDF5 data format. We demonstrate the platform with a computing heavy use case in seismology: ambient noise seismology of DAS data. We process one month of data, pairing all 2089 channels within 24 hr using AWS Batch autoscaling.
Application of multicolor flow cytometry in liquid biopsy of breast cancer
Authors: Kaigorodova E. V. , Grishchenko M. Yu. 
Published: October 2023

As a result of the clinical study NCT04817501 “Phenotypic characterization of circulating tumor cells (CTCs) in tumors of the female reproductive system”, we developed a method for preoperative prediction of a recurrence risk in patients with stage T1 endometrial cancer (Patent No. 2762493 of 21.12.2021).The article presents a clinical case of the use of multicolor flow cytometry in liquid biopsy of breast cancer (BC). CTCs were detected in the blood of a patient with T2N0M0 BC, stage IIA before the initiation of treatment. Using multicolor flow cytometry, various CTC phenotypes were studied and the Her2/neu and ki-67 markers were determined. These markers were also studied in the biopsy and surgical material of the BC tissue using immunohistochemistry. As a result of the study, it was shown that the molecular profile of CTCs in the blood taken before fine needle aspiration biopsy coincided with that of cancer cells in the BC tissue. In addition, the calculated risk of tumor progression before biopsy predicted recurrence of cancer in this patient 20 months before its occurrence. The obtained results show the practical utility of multicolor flow cytometry in liquid biopsy of cancers. The ability to evaluate CTCs by various molecular parameters can be useful for diagnosing, predicting, monitoring, and determining treatment strategies for cancer patients.
Prognostic value of humoral markers in patients with anthracycline-related cardiac dysfunction
Authors: Grakova E. V. , Kopeva K. V. , Shilov S. N. , Bobyleva E. T. , Berezikova E. N. , Kalyuzhin V. V. , Teplyakov A. T. 
Published: October 2023

Aim. To carry out a 12-month study on the prognostic role of humoral markers responsible for the main mechanisms of initiation of cardiotoxic myocardial damage (endothelin-1, soluble Fas-L, N-terminal pro-brain natriuretic peptide (NT-proBNP), tumor necrosis factor-α, interleukin (IL)-1β, matrix metalloproteinase (MMP)-2 and MMP9, soluble form of the ST2 protein (sST2), a tissue inhibitor of metalloproteinase-1, and tetranectin) in assessing the risk of progression of anthracycline-related left ventricular dysfunction.Materials and methods. The study included a total of 114 women aged 48.0 (46.0; 52.0) years without concomitant cardiovascular diseases and risk factors who received chemotherapy with anthracyclines in the past. The levels of serum biomarkers were determined using the enzyme immunoassay. Transthoracic echocardiography was performed at baseline and at 12 months of follow-up.Results. After 12 months of follow-up, all patients were retrospectively divided into 2 groups: group 1 (n = 54) included patients with an unfavorable course of anthracycline-related cardiac dysfunction (ARCD), group 2 (n = 60) encompassed patients with a favorable course of the disease. According to the ROC analysis, MMP-2 ≥ ≥ 338.8 pg / ml (sensitivity 57%, specificity 78%; AUC = 0.629; p = 0.025), MMP-9 ≥ 22.18 pg / ml (sensitivity 89%, specificity 87%; AUC = 0.886; p < 0.001), sST2 ≥ 32.4 ng / ml (sensitivity 64%, specificity 70.5%; AUC = 0.691; p = 0.002), and tetranectin ≤ 15.4 pg / ml (sensitivity 69%, specificity 72%; AUC = 0.764; p < 0.001) were identified as predictors of an adverse course of ARCD. When comparing ROC curves, it was found that the concentration of MMP-9 (p = 0.002) was the most significant predictor of the progression of ARCD.Conclusion. MMP-2 and -9, soluble ST2, and tetranectin can be considered as non-invasive markers for assessing the risk of ARCD progression. At the same time, an increased level of MMP-9 is the most significant predictor of ARCD progression.
Influence of pulse laser energy on the Nickel plasma characteristics that produced in laser-induced plasma system
Authors: Mazhir Sabah N. , Abbas Huda H. 
Published: October 2023

تُستخدم تقنية قياس طيف الانبعاث البصري ( OES) لتحليل البلازما المتولدة من هدف (النيكل) المضاء باستخدام ليزر Q- Switched (Nd: YAG) بطاقات مختلفة في الهواء. تم استخدام طريقة التوسيع Boltzmann-Plot و Stark لحساب معاملات البلازما بما في ذلك كثافة الإلكترون (ne) ودرجة حرارة الإلكترون (Te) وتردد البلازما (fp) وطول ديباي (λD). يتضح أن قيم (ne) و (Te) و (λD) و (fp) تزداد بزيادة طاقة الليزر مع قيم درجة حرارة الإلكترون المحسوبة التي تتراوح بين (0.934 - 1.479) الكترون - فولت.
Fossil Fuel Communities Support Climate Policy Coupled with Just Transition Assistance
Authors: Gazmararian Alexander F. 
Published: October 2023

Abstract
What are fossil fuel communities’ preferences over the design of just transition as-sistance accompanying climate policy? This study conducted survey experiments at Appalachian county fairs to answer this question, overcoming barriers that have lim-ited previous attempts to measure preferences in these crucial regions. Comparing the responses to a new national survey, there is a divergence in preferences for policies en-couraging relocation, but there is convergence behind support for policies that reduce costs to fossil fuel workers. The study also finds that an intervention to provide in-formation about coal’s decline shifted preferences toward supporting the clean energy transition. Rather than public opinion being an immutable barrier to climate action, 66% of fossil fuel community residents would endorse climate policy if it were coupled with just transition assistance. Policy design and informational interventions could help to create climate coalitions, even in the places most affected by the clean energy transition.
General Purpose Propofol Target Controlled Infusions Using the Marsh Model with Adjusted Body Weight
Authors: Zhong George , Xu Xiabing 
Published: October 2023

Abstract
Purpose
We report a novel method for adjusting the input weight of the Marsh target controlled infusion (TCI) model so that it mimics the behavior of the Eleveld model. In this study, we compare the performance of our weight adjusted Marsh model with the Eleveld model across diverse patient groups in silico.

Methods
We simulated 2,768 subjects with diverse combinations of age, weight, height and sex undergoing a hypothetical four-hour propofol TCI with either the Eleveld model or the Marsh model using our adjusted input weight. The performance of our augmented Marsh model was compared with the Eleveld model using established methods.

Results
The Marsh model using our adjusted weight input produced infusion regimes and effect site concentrations closely mimicking that of the Eleveld model for all simulated patients. The median and maximum absolute performance errors of our augmented Marsh model for the worst performing case was 8.1% and 20.3%, respectively, compared to the Eleveld model.

Conclusion
By adjusting the input weight using our novel algorithm, the infusion regime of the Marsh model produced effect site concentrations closely mimicking that of the Eleveld model. We believe this is a robust way of improving the precision of the Marsh model, especially in patients at extremes of age and body mass index, until the Eleveld model becomes more widely available in commercial infusion pumps.
Directed crystallization of a poly(3,4-ethylenedioxythiophene) film by an iron(III) dodecyl sulfate lamellar superstructure
Authors: Kim Sungsoo , MA FENG , Choi Sang-il , Lee Dooyong , Park Sungkyun , Cho Sung-Pyo , Boo Jin-Hyo 
Published: October 2023

Abstract

The synthesis and properties of the poly(3,4-ethylenedioxythiophene):dodecyl sulfate (PEDOT:DS) film are presented and its directed crystallization is described. Iron(III) dodecyl sulfate (Fe(DS)3) multi-lamellar vesicles (MLVs), a newly introduced growth template and a key factor upgrading the vapor-phase polymerization (VPP) of 3,4-ethylenedioxythiophene (EDOT), was used to synthesize a highly conductive, transparent, and mechanically durable film specifically suitable for next-generation flexible electronics. The PEDOT film formed with Fe(DS)3, and doped with DS anions, is highly transparent, metallically conductive (max. ~1.1 × 104 S cm-1), and mechanically highly durable but still flexible. These outstanding physical properties of the VPP-PEDOT film exclusively originate from the MLVs of Fe(DS)3, which have a lamellar superstructure, and simultaneously play several advantageous roles during VPP: a highly effective oxidant without side reactions, a highly efficient in-situ dopant, a template for large-scale crystal growth, and an enhancer of water resistance and durability. The crystal growth of PEDOT is directed by several hundred micrometer-sized lamellar planes of the densely packed Fe(DS)3 surfactant molecules to fabricate a PEDOT:DS co-crystal of approximately the same size. These findings provide a new direction for the synthesis of more conductive, transparent, robust, and flexible polymer electrode materials in future by constructing MLV-type oxidants with a more sophisticated design.
Repurpose Type I-A CRISPR-Cas3 for a Robust HPV Diagnosis
Authors: Hu Chunyi , Hu Tao , Ji Quanquan , Ke Xinxin , Zhou Hufeng , Yu Chenlin , Ju Wenjun , Lu Meiling , Lin Yu , Ou Yangjing , Zhou Yingsi , Xiao Yibei , Xu Chunlong 
Published: October 2023

Abstract

R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for nucleic acid detection. However, the hyperactive ssDNase activity of Cas3 introduces unwanted noise and false-positive results. In this study, we identified a novel Type I-A Cas3 variant derived from Thermococcus siculi, which remains in an auto-inhibited state until it is triggered by Cascade complex and R-loop formation. This Type I-A CRISPR-Cas3 system not only exhibits an expanded protospacer adjacent motif (PAM) recognition capability but also demonstrates remarkable intolerance towards mismatched sequences. Furthermore, it exhibits dual activation modes—responding to both DNA and RNA targets. The culmination of our research efforts has led to the development of the Hyper-Active-Verification Establishment (HAVE, 惠父). This innovation enables swift and precise human papillomavirus (HPV) diagnosis in clinical samples, providing a robust molecular diagnostic tool based on the Type I-A CRISPR-Cas3 system. Our findings contribute to understanding type I-A CRISPR-Cas3 system regulation and facilitate the creation of advanced diagnostic solutions with broad clinical applicability.