bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction to Special Section: Considerations and Potential Impacts
Authors: Garcia Moriana M. , Colegrove Tod 
Published: October 2023

EDITOR'S SUMMARYASIS&T Special Interest Group/Scientific and Technical Information convened a panel at the ASIS&T 2014 Annual Meeting that explored potential impacts of 3D design and printing on libraries, museums and educational institutions. Rooted in the 1970s, the current 3D printing process was first used in 1984 and now allows limitless creations to be made by downloading or scanning and printing a digital file. The tangible product vitalizes interaction with the original and among viewers, enhances understanding and stimulates creativity. But, as with the use of photocopiers, questions of ethics and intellectual property arise. Management of the technology also raises practical questions of access, workflow, budgeting and support.This special section delves into 3D technologies as teaching tools and considers policy, copyright and intellectual freedom, critical issues for information professionals. Articles open with a discussion of the use of 3D printers in library makerspaces by community members, the potential for broad experiential learning and practical issues for libraries. An exploration of 3D printer use for academic studies far beyond traditional areas follows, with a look at collaborative efforts between university departments to support and use the equipment and a reminder of the need for ethical management and consumer education about 3D resources. The final articles explore the benefits of manipulating 3D copies of museum pieces and enjoying the creative potential for hands‐on activities in various settings, as well as contemplating libraries' role in adapting intellectual freedom policy for 3D technologies.
Digital Fabrication Technology in the Library: Where We Are and Where We Are Going
Authors: Prato Stephanie C. , Britton Lauren 
Published: October 2023

EDITOR'S SUMMARYMakerspaces are environments where crafters and techies can come together to create, share and learn. Many libraries support the maker movement by providing access to a variety of technologies from sewing machines and looms to recording equipment and production tools, an expansion of services that is in line with promoting literacy, community and lifelong learning. About one third of makerspaces charged a fee or required membership in 2013, though some, including libraries and museums, are supported by major funding agencies. Digital fabrication technology or 3D printers are increasingly available through library‐based makerspaces and extend opportunities for STEM education, but libraries face challenges from high initial and ongoing costs, user training and even encouraging users in 3D thinking and design. 3D printers can be a powerful stimulus for creativity, learning and sharing, even promoting jobs and community development.
How 3D Printers Support Teaching in Engineering, Technology and Beyond
Authors: Van Epps Amy , Huston Davin , Sherrill John , Alvar Ann , Bowen Anna 
Published: October 2023

EDITOR'S SUMMARYThe rise of 3D printers derives from the need to create physical prototypes for engineering and manufacturing rapidly and inexpensively, but the technology has been widely adopted for innumerable applications. A library can provide a central point of access and support for 3D printing for students and faculty across disciplines and programs beyond engineering and technology. Nontraditional uses include teaching persuasive communications through visual rhetoric in an English class, creating objects that can diffuse stereotypes and attitudes and enhancing understanding of physical anatomy. Numerous 3D model datasets and software are available for printing projects. 3D printing not only promotes learning but inspires creativity and fun.
Library as Collaboratory: Partnerships, Knowledge Transfer and Dialogue in Library‐based 3D Services
Authors: Messner Kevin R. 
Published: October 2023

EDITOR'S SUMMARYSince 2012 the 3D printing operation at Miami University's Business, Engineering, Science and Technology Library has developed into a high demand service that promotes learning for a broad range of users. With the first two basic 3D printers set up in separate locations, multiple operators developed skills and provided backup support for each other. A variety of user groups emerged beyond the expected subject disciplines and applications, and, with a growing circle of users, students have been employed for printing tasks, gaining technical skills and enabling the library to expand its services. Placing printers in highly visible locations prompted interest and interactions among onlookers. Strong demand for the 3D printing service has necessitated coordination between the library and departments, collaboration between departments, prioritization of needs and funding for more durable equipment, while stimulating developments in curricula and research agendas.
Museums and 3D Printing: More Than a Workshop Novelty, Connecting to Collections and the Classroom
Authors: Hancock Megan 
Published: October 2023

EDITOR'S SUMMARYA typical museum visitor views an artwork for about half a minute, but 3D scanning and printing technology can help provide a more meaningful experience. Several museums have invited audiences to hands‐on 3D scanning and printing events, encouraging them to engage with museum pieces more deeply, creating 3D photo files and ultimately constructing 3D printed models of the pieces that can be manipulated and interacted with in new ways. The ARTLAB+ program in Washington, D.C., and the Parachute Factory in New Mexico are examples of makerspaces focusing on hands‐on activities with cutting edge technologies including 3D printers for a variety of users. A special exhibit on 3D technology at the British Museum and Samsung Digital Discovery Center enabled visitors to recreate museum pieces with computer‐aided design technology, 3D pens and 3D printing. A resource list describes additional projects and information sources.
Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells
Authors: Zhang Xiong , Peng Ming‐You , Feng En‐Ming , Li Qing‐Dan , Chen Lu , Yang Hu‐Cheng , Guo Bing , Liang Hong , Di Ying‐Tong , Tang Lei , Yan Ying 
Published: October 2023

AbstractThree previously undescribed diterpenoids, helioscopnoids A–C, and eight known compounds were isolated from the whole plants of Euphorbia helioscopia. Their structures were established by extensive analysis of spectra and data comparison with previous literatures. Among them, compound 4 was identified as 24,24‐dimethoxy‐25,26,27‐trinoreuphan‐3β‐ol with revised configurations of C‐13, C‐14, and C‐17 (13R*, 14R*, 17R*). Cytotoxicity assays revealed that all compounds exhibited varying levels of cytotoxicity against H1975 cells, with compound 9 displaying the most potent activity, as indicated by cell viability rates of 18.13 % and 20.76 % at concentrations of 20 μM and 5 μM, respectively. This study expands the understanding of E. helioscopia terpenoids’ structural diversity and biological activities, contributing to the exploration of potential therapeutic applications.
From Natural Insulin to Designed Analogs: A Chemical Biology Exploration
Authors: Zhang Yanxian , Hung‐Chieh Chou Danny 
Published: October 2023

AbstractSince its discovery in 1921, insulin has been at the forefront of scientific breakthroughs. From its amino acid sequencing to the revelation of its three‐dimensional structure, the progress in insulin research has spurred significant therapeutic breakthroughs. In recent years, protein engineering has introduced innovative chemical and enzymatic methods for insulin modification, fostering the development of therapeutics with tailored pharmacological profiles. Alongside these advances, the quest for self‐regulated, glucose‐responsive insulin remains a holy grail in the field. In this article, we highlight the pivotal role of chemical biology in driving these innovations and discuss how it continues to shape the future trajectory of insulin research.
Bioorthogonal Chemistry in Translational Research: Advances and Opportunities
Authors: Chaudhuri Ritapa , Bhattacharya Semantee , Dash Jyotirmayee 
Published: October 2023

AbstractBioorthogonal chemistry is a rapidly expanding field of research that involves the use of small molecules that can react selectively with biomolecules in living cells and organisms, without causing any harm or interference with native biochemical processes. It has made significant contributions to the field of biology and medicine by enabling selective labeling, imaging, drug targeting, and manipulation of bio‐macromolecules in living systems. This approach offers numerous advantages over traditional chemistry‐based methods, including high specificity, compatibility with biological systems, and minimal interference with biological processes. In this review, we provide an overview of the recent advancements in bioorthogonal chemistry and their current and potential applications in translational research. We present an update on this innovative chemical approach that has been utilized in cells and living systems during the last five years for biomedical applications. We also highlight the nucleic acid‐templated synthesis of small molecules by using bioorthogonal chemistry. Overall, bioorthogonal chemistry provides a powerful toolset for studying and manipulating complex biological systems, and holds great potential for advancing translational research.
Ectopic pancreatic tissue in a cholecystectomy specimen: A rare incidental pathologic finding
Authors: Zaresharifi Nooshin , Khalili Anita , Eftekhari Behrad , Layegh Hojjat 
Published: October 2023

AbstractEctopic pancreatic tissue is a rare congenital abnormality defined as the abnormal location of pancreatic tissue outside the anatomical site of the pancreas without any anatomical or vascular connection to it, which is often discovered incidentally. This is a case of a 40‐year‐old man who was admitted to our surgical department for emergency cholecystectomy due to acute gangrenous cholecystitis. Preoperative ultrasound imaging was indicative only of multiple stones in the gallbladder. Postoperative histopathological examination revealed an area of wall thickening in the neck region of the gallbladder consists of ectopic pancreatic tissue. We emphasize the role of a precise pathologic examination even in routine surgical specimens such as a cholecystectomy specimen, since no preoperative evaluation can be affirmative of such incidental but momentous histopathologic findings. Anatomical pathologists must be aware of the rare presentation of Ectopic Pancreatic Tissue (EPT) in gallbladder which may masquerade as a malignancy.
A late diagnosis of primary intestinal lymphangiectasia in a Syrian girl
Authors: Najjar Afaf Mohammad Maher , Babensi Nour Khaled , Ghazal Ahmad , Brimo Alsaman Muhamad Zakaria , Ismail Alaa aldin , Alnaeb Hasnaa 
Published: October 2023

Key Clinical MessagePrimary intestinal lymphangiectasia is a rare disease that affects children and young adults, causing mainly gastrointestinal disorders that lead to edema and immunologic abnormalities. The majority of patients typically present bilateral lower limb edema, along with pericarditis, pleural effusion, or chylous ascites. The goal of the treatment is to restrict the consumption of long‐chain fats and administer a formula that includes protein and medium‐chain triglycerides. Here, we report 11‐year‐old Syrian girl presented to the hospital with 2 years history of diarrhea and generalized edema. Furthermore, investigation showed ascites and pleural effusion. The disease was detected by several biopsies from duodenum that showed dilation of the lymph vessels within the lamina propria without any evidence for inflammation. She was managed by modifying her diet and albumin transfusion, which caused significant improvement in the child's condition.
A case of bladder and pelvic dead space inflammation successfully treated with endoscopic ultrasound drainage
Authors: Hiyama Kazuhiro , Kirino Izumi , Fukui Yasuo 
Published: October 2023

Key Clinical MessageInterventional endoscopic ultrasound (EUS) is effective not only for biopsy, but also for abscess drainage. We report the first use of EUS to drain inflammation of the bladder and pelvic dead space through the ileal conduit. EUS‐guided drainage is effective in treating postoperative abscesses and should be employed more routinely.AbstractThe patient was a 77‐year‐old man with a vesicoureteral fistula. An ileal conduit was placed after abdominoperineal resection and partial bladder resection for local, postoperative recurrence of rectal cancer. During postoperative chemotherapy, the patient developed a high‐grade fever and after a thorough examination, he was diagnosed with bladder and pelvic dead‐space inflammation. All urine flowed through the ileal conduit, and it was assumed that secretions from the residual bladder and prostate gland had accumulated in the bladder and pelvic cavity, resulting in infection. A transcutaneous drain was inserted through the perineum and the infection was controlled, but it flared up again after the drain was removed. We concluded that long‐term drainage was necessary and successfully controlled the infection by placing a plastic stent through the ileal conduit into the bladder and pelvic dead space under ultrasound endoscopy. This is the first report of ultrasound endoscopic drainage of an abscess through the ileal conduit.
A Modular and Convergent Synthetic Route to Supramolecular Cyclic Dimers Based on Amidinium‐Carboxylate Interactions
Authors: López‐Martín Isabel , Veiga‐Herrero Jacobo , Aparicio Fátima , González‐Rodríguez David 
Published: October 2023

AbstractWe describe herein the optimized design and modular synthetic approach towards supramolecularly programmed monomers that can form discrete macrocyclic species of controllable size and shape through amidinium‐carboxylate interactions in apolar and polar media.
An Aryl‐ether‐linked Covalent Organic Framework Modified with Thioamide Groups for Selective Extraction of Palladium from Strong Acid Solutions
Authors: Zhao Fuqiang , Bai Yaoyao , Zhou Xiaoyuan , He Linwei , Tao Yunnan , Chen Junchang , Zhang Mingxing , Guo Qi , Ma Zhonglin , Chen Long , Zhu Lin , Duan Tao , Chai Zhifang , Wang Shuao 
Published: October 2023

AbstractEfficient adsorption of palladium ions from acid nuclear waste solution is crucial for ensuring the safety of vitrification process for radioactive waste. However, the limited stability and selectivity of most current adsorbents hinder their practical applications under strong acid and intense radiation conditions. Herein, to address these limitations, we designed and synthesized an aryl‐ether‐linked covalent organic framework (COF‐316‐DM) grafted dimethylthiocarbamoyl groups on the pore walls. This unique structure endows COF‐316‐DM with high stability and exceptional palladium capture capacity. The robust polyarylether linkage enables COF‐316‐DM to withstand irradiation doses of 200 or 400 kGy of β/γ ray. Furthermore, COF‐316‐DM demonstrates fast adsorption kinetics, high adsorption capacity (147 mg g−1), and excellent reusability in 4 M nitric acid. Moreover, COF‐316‐DM exhibits remarkable selectivity for palladium ions in the presence of 17 interference ions, simulating high level liquid waste scenario. The superior adsorption performance can be attributed to the strong binding affinity between the thioamide groups and Pd2+ ions, as confirmed by the comprehensive analysis of FT‐IR and XPS spectra. Our findings highlight the potential of COFs with robust linkers and tailored functional groups for efficient and selective capture of metal ions, even in harsh environmental conditions.
Control of Substrate Conformation by Hydrogen Bonding in a Retaining β‐Endoglycosidase
Authors: Nin‐Hill Alba , Ardevol Albert , Biarnés Xevi , Planas Antoni , Rovira Carme 
Published: October 2023

AbstractBacterial β‐glycosidases are hydrolytic enzymes that depolymerize polysaccharides such as β‐cellulose, β‐glucans and β‐xylans from different sources, offering diverse biomedical and industrial uses. It has been shown that a conformational change of the substrate, from a relaxed 4C1 conformation to a distorted 1S3/1,4B conformation of the reactive sugar, is necessary for catalysis. However, the molecular determinants that stabilize the substrate's distortion are poorly understood. Here we use quantum mechanics/molecular mechanics (QM/MM)‐based molecular dynamics methods to assess the impact of the interaction between the reactive sugar, i. e. the one at subsite −1, and the catalytic nucleophile (a glutamate) on substrate conformation. We show that the hydrogen bond involving the C2 exocyclic group and the nucleophile controls substrate conformation: its presence preserves sugar distortion, whereas its absence (e.g. in an enzyme mutant) knocks it out. We also show that 2‐deoxy‐2‐fluoro derivatives, widely used to trap the reaction intermediates by X‐ray crystallography, reproduce the conformation of the hydrolysable substrate at the experimental conditions. These results highlight the importance of the 2‐OH⋅⋅⋅nucleophile interaction in substrate recognition and catalysis in endo‐glycosidases and can inform mutational campaigns aimed to search for more efficient enzymes.
Extremely Stable Perylene Bisimide‐Bridged Regioisomeric Diradicals and Their Redox Properties
Authors: Feng Zhibin , Zhou Jiadong , He Xiandong , Wang Bohan , Xie Guojing , Qiao Xianfeng , Liu Linlin , Xie Zengqi , Ma Yuguang 
Published: October 2023

AbstractExcellent stability is an essential premise for organic diradicals to be used in organic electronic and spintronic devices. We have attached two tris(2,4,6‐trichlorophenyl)methyl (TTM) radical building blocks to the two sides of perylene bisimide (PBI) bridges and obtained two regioisomeric diradicals (1,6‐TTM‐PBI and 1,7‐TTM‐PBI). Both of the isomers show super stability rather than the monomeric TTM under ambient conditions, due to the increased conjugation and the electron‐withdrawing effects of the PBI bridges. The diradicals show distinct and reversible multistep redox processes, and a spectro‐electrochemistry investigation revealed the generation of organic mixed‐valence (MV) species during reduction processes. The two diradicals have singlet ground states, very small singlet–triplet energy gaps (ΔES‐T) and a pure open‐shell character (with diradical character y0=0.966 for 1,6‐TTM‐PBI and 0.967 for 1,7‐TTM‐PBI). This work opens a window to developing very stable diradicals and offers the opportunity of their further application in optical, electronic and magnetic devices.
Electron Paramagnetic Resonance, Electronic Ground State, and Electron Spin Relaxation of Seven Lanthanide Ions Bound to Lanmodulin and the Bioinspired Chelator, 3,4,3‐LI(1,2‐HOPO)
Authors: Larrinaga Wyatt B. , Cotruvo Joseph A. , Worrell Brady T. , Eaton Sandra S. , Eaton Gareth R. 
Published: October 2023

AbstractThe electron paramagnetic resonance (EPR) spectra of lanthanide(III) ions besides Gd3+, bound to small‐molecule and protein chelators, are uncharacterized. Here, the EPR properties of 7 lanthanide(III) ions bound to the natural lanthanide‐binding protein, lanmodulin (LanM), and the synthetic small‐molecule chelator, 3,4,3‐LI(1,2‐HOPO) (“HOPO”), were systematically investigated. Echo‐detected pulsed EPR spectra reveal intense signals from ions for which the normal continuous‐wave first‐derivative spectra are negligibly different from zero. Spectra of Kramers lanthanide ions Ce3+, Nd3+, Sm3+, Er3+, and Yb3+, and non‐Kramers Tb3+ and Tm3+, bound to LanM are more similar to the ions in dilute aqueous:ethanol solution than to those coordinated with HOPO. Lanmodulins from two bacteria, with distinct metal‐binding sites, had similar spectra for Tb3+ but different spectra for Nd3+. Spin echo dephasing rates (1/Tm) are faster for lanthanides than for most transition metals and limited detection of echoes to temperatures below ~6 to 12 K. Dephasing rates were environment dependent and decreased in the order water:ethanol>LanM>HOPO, which is attributed to decreasing librational motion. These results demonstrate that the EPR spectra and relaxation times of lanthanide(III) ions are sensitive to coordination environment, motivating wider application of these methods for characterization of both small‐molecule and biomolecule interactions with lanthanides.
Patient‐reported symptom monitoring and adherence to therapy in patients with newly diagnosed chronic myeloid leukemia
Authors: Efficace Fabio , Cottone Francesco , Yanez Betina , Kota Vamsi , Castagnetti Fausto , Caocci Giovanni , Bonifacio Massimiliano , Patriarca Andrea , Capodanno Isabella , Miggiano Maria Cristina , Tiribelli Mario , Breccia Massimo , Luciano Luigia , Giai Valentina , Iurlo Alessandra , Abruzzese Elisabetta , Fava Carmen , Dinner Shira , Altman Jessica K. , Rosti Gianantonio , Cortes Jorge , Vignetti Marco , Cella David 
Published: October 2023

AbstractBackgroundThe authors assessed the clinical utility of patient‐reported symptom monitoring in the setting of newly diagnosed chronic myeloid leukemia (CML). The primary objective was to evaluate adherence to therapy.MethodsThe authors conducted an international prospective study that included patients with newly diagnosed, chronic‐phase CML. Before clinical consultation, patients were provided a tablet computer to self‐rate their symptoms, and the results were available in real time to each physician during the patient’s visit. Adherence was assessed by pill count and with a validated self‐reported questionnaire. The proportions of optimal responders at 3 and 6 months were assessed according to the European LeukemiaNet criteria.ResultsBetween July 2020 and August 2021, 94 patients with a median age of 57 years were enrolled. Pill count adherence analysis indicated that 86 of 93 evaluable patients (92.5%) took at least 90% of prescribed tyrosine kinase inhibitor therapy during the 6‐month observation period. The online platform was well accepted by patients and physicians. An optimal response was achieved by 69 of 79 patients (87.3%) at 3 months and by 61 of 81 patients (75.3%) at 6 months.ConclusionsPatient‐reported symptom monitoring from the beginning of therapy in patients with CML may be critical to improve adherence to therapy and early molecular response rates (ClinicalTrials.gov identifier NCT04384848).