bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a high efficiency cross-domain medical image retrieval system using augmented transfer learning
Authors: Ahmed Syed Tanzeem , Zuber Mohd , Jadhav Yogesh , Patel Ashish , Patil Vishal 
Published: January 2024

Abstract
Retrieving medical images from a large inter-domain dataset requires multiple high efficiency processing models. These models include, but are not limited to, image classification, domain specific feature extraction & selection, ranking and post processing. A wide variety of system models have been designed to perform these tasks, but have limited accuracy, and retrieval performance due to improper cross-domain feature processing. In order to improve performance of cross-domain medical image retrieval systems, this text proposes a transfer learning mechanism, that learns from features of one domain, and applies the trained models to other domains. The proposed method uses a combination of VGGNet19, AlexNet, InceptionNet and Xception Net models for ensemble learning, along with wavelet and bag of features (WBoF) for efficient feature extraction. Each of the individual models were applied to different medical domains, and their retrieval accuracies were evaluated. Based on this evaluation, it is observed that VGGNet19 has better performance on computer tomography (CT) images, AlexNet model has better performance on Magnetic resonance imaging (MRI) images, InceptionNet model has better performance on positron emission tomography (PET) images, while Xception Net has better retrieval performance for ultrasound (USG) images. Using this observation, a highly efficient augmentation model is designed, which achieves an accuracy of 98.06%, precision of 65.9%, recall of 76.1%, and area under the curve (AUC) performance of 98.9% on different datasets. This performance is compared with a wide variety of medical image datasets including Center for Invivo Microscopy (CIVM), Embrionic and Neonatal Mouse (H&E, MR), LONI image data archive, The Open Access Series of Imaging Studies (OASIS), & CT scans for Colon Cancer (CSCC). It was observed that the proposed model outperforms most of the recent state-of-the-art models, and achieves consistent parametric results across multiple domain medical images.
Cognitive performance of grey mouse lemurs (Microcebus murinus) during a discrimination learning task: Effect of the emotional valence of stimuli
Authors: Mortessagne Eugénie , Bovet Dalila , Nozières Camille , Pouydebat Emmanuelle , Pifferi Fabien 
Published: January 2024

Abstract
Emotions are omnipresent in many animals’ lives. It is a complex concept that encompasses physiological, subjective, behavioural and cognitive aspects. While the complex relationship between emotion and cognition is well studied in humans, it has yet to be explored in other primate species, such as lemurs. In our study, we evaluated the performance of N=48 grey mouse lemurs (Microcebus murinus) in a discrimination learning task using visual emotional stimuli. We tested whether the type of visual stimulus (positive, negative or neutral) influenced the cognitive performance of mouse lemurs. Individuals had to learn to discriminate between two platforms according to the associated visual stimuli and to jump to the target platform (leading to a reward). Our main finding was that emotional stimuli, whether positive or negative in valence, impaired cognitive performance when used as a target. Specifically, the lowest success rate occurred when the target was associated with the emotional stimuli, and the highest success rate occurred when it was associated with neutral stimuli. Our results show a similar pattern to that found in other primate species and support the adaptative role of emotion. This study is the first to explore how emotions interfere with the cognitive abilities of a lemur species. This highlights the importance of acknowledging emotion in mouse lemurs as well as studying the emotion-cognition interaction in a wider range of primate species.
Four classic “de novo” genes all have plausible homologs and likely evolved from retro-duplicated or pseudogenic sequences
Authors: Bozorgmehr Joseph Hannon 
Published: January 2024

Abstract
Despite being previously regarded as extremely unlikely, the idea that entirely novel protein-coding genes can emerge from non-coding sequences has gradually become accepted over the past two decades. Examples of “de novo origination”, resulting in lineage-specific “orphan” genes, lacking orthologs, are now produced every year. However, many are likely cases of duplicates that are difficult to recognize. Here, I re-examine the claims and show that four very well-known examples of genes alleged to have emerged de novo “from scratch” - namely FLJ33706 in humans, Goddard in fruit flies, BSC4 in baker’s yeast and AFGP2 in codfish - all have plausible evolutionary ancestors in pre-existing genes. In the case of the first two, highly diverged retrogenes that code for regulatory proteins may have been misidentified as being orphans. The antifreeze glycoproteins in cod, moreover, are shown to have likely not evolved from repetitive non-genic sequences but, as in other related cases, from an apolipoprotein that may well have been pseudogenized before later being reactivated. These findings detract from various claims made about de novo gene birth and show there has been a tendency not to invest the necessary effort in searching for homologs outside of a very limited syntenic or phylostratigraphic methodology. An approach used here for improving homology detection draws upon similarities, not just in terms of statistical sequence analysis, but also with biochemistry and function, in order to obviate failure.
Effect observation of problem-based learning in obstetric and gynecological clinical nursing teaching
Authors: Li Yanyan , Zhu Ruixue 
Published: January 2024

Abstract
Background: Problem-based learning (PBL) is a "problem" centered teaching method, and it is also a critical new way needed in the nursing teaching of obstetrics and gynecology. Therefore, it is necessary to explore the effect of problem-based learning (PBL) in clinical nursing teaching of obstetrics and gynecology.
Methods: 90 trainee nursing students of obstetrics and gynecology were randomly divided into control group (n=45, using traditional teaching mode) and PBL group (n=45, using PBL), and the teaching quality and other indicators were compared.
Results: The teaching quality, assessment scores, graduation scores and satisfaction of nursing interns in the PBL group were all higher than those in the control group, and the differences were statistically significant (P<0.05).
Conclusion: The application of PBL in obstetrics and gynecology nursing teaching is of great significance.
Additive manufacturing of a 3D-segmented plastic scintillator detector for tracking and calorimetry of elementary particles
Authors: Sgalaberna Davide , Weber Tim , Boyarintsev Andrey , Kose Umut , Li Botao , Sibilieva Tetiana , Berns Siddartha , Boillat Eric , De Roeck Albert , Dieminger Till , Dolan Stephen , Franks Matthew , Grynyov Boris , Hugon Sylvain , Jaeschke Carsten , Rubbia André 
Published: January 2024

Abstract
Plastic-scintillator detectors are among the most common devices used for the detection of elementary particles. They provide good particle identification combined with excellent time resolution, whilst being inexpensive due to the affordability of plastic materials. Particle tracking is achieved by segmenting the scintillator into smaller, independent, optically-isolated voxels.
Enhancing the performance of future particle detectors necessitates larger total volumes, possibly combined with even finer segmentation. However, manufacturing such designs with current production strategies is challenging. These strategies involve a variety of time-consuming and costly fabrication processes, followed by the assembly of millions of individual parts. The difficulty in scaling up such a complex workflow underscores the need for technological advancements, which can be met by additive manufacturing. This method enables the construction of complex, monolithic geometries in a single operation. These geometries consist of fine three-dimensional granular sub-structures and require the integration of multiple types of plastic materials, as well as space to accommodate optical fibers, all within a compact volume of several cubic meters.
This article presents the fabrication and performance evaluation of the first additive manufactured single-block plastic scintillator detector. To achieve this, a new method called Fused Injection Modeling has been specially developed. The detector is capable of three-dimensional tracking of elementary particles and accurately measuring their stopping power. Its performance is comparable to the current state of the art of plastic scintillator detectors.
This work paves the way towards a new feasible, time and cost-effective process for the production of future scintillator detectors, regardless their size and difficulty in geometry.
Environmental pollution as a result of a vacuum deficit in the working areas during asbestos removal work.
Authors: Obmiński Andrzej 
Published: January 2024

Abstract

The paper presents examples of the consequences of the lack of negative pressure in the work zone during asbestos removal. The results obtained for dust concentrations generated during these works in the work zone were relatively low compared to the literature data. This was due to the leakage of barriers restricting the work zone and the 'leakage' of dust. Therefore the asbestos content in the outdoor air in the vicinity of the renovated rooms was increasing. In the discussed cases, those works polluted the outdoor air for up to 15 m. The risk of asbestos dust content in the cleaned building outside the work area also increased. Those places often are not well controlled. Therefore, this may lead to long-term retention of asbestos dust in the facility despite the completion of the process of removing asbestos products from it. For example, non-friable asbestos- cement sheets removal in those work conditions increased contamination up to 3000 f/m3 outside the work zone. In the case of work with friable asbestos in building type “LIPSK”, contamination locally was up 21 000 f/m3. These values are above the average concentration of asbestos fibres in buildings of this type normally used and after works to correct asbestos removal (< 300–400 f/m3). Reported indoor air research results from the work zone in the case of the lack of negative pressure, without documented sampling conditions and contractor working methods, can falsely suggest a high standard of work quality.
An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death
Authors: Kim Yang-Hee , Eom Jae-Won , Lee Jin Yeon 
Published: January 2024

Abstract

In the context of acute brain injuries, where zinc neurotoxicity and oxidative stress are acknowledged contributors to neuronal damage, we investigated the pivotal role of lysosomes as a potential protective mechanism. Our research commenced with an exploration of epidermal growth factor (EGF) and its impact on lysosomal dynamics, particularly its neuroprotective potential against zinc-induced cytotoxicity. Using primary mouse cerebrocortical cultures, we observed the rapid induction of EGFR endocytosis triggered by EGF, resulting in a transient increase in lysosomal vesicles. Furthermore, EGF stimulated lysosomal biogenesis, evident through elevated expression of lysosomal-associated membrane protein 1 (LAMP-1) and the induction and activation of prominent lysosomal proteases, particularly cathepsin B (CTSB). This process of EGFR endocytosis was found to promote lysosomal augmentation, thus conferring protection against zinc-induced lysosomal membrane permeabilization (LMP) and subsequent neuronal death. Notably, the neuroprotective effects and lysosomal enhancement induced by EGF were almost completely reversed by the inhibition of clathrin-mediated and caveolin-mediated endocytosis pathways, along with the disruption of retrograde trafficking. Furthermore, tyrosine kinase inhibition of EGFR nullified EGFR endocytosis, resulting in the abrogation of EGF-induced lysosomal upregulation and neuroprotection. An intriguing aspect of our study is the successful replication of EGF’s neuroprotective effects through the overexpression of LAMP-1, which significantly reduced zinc-induced LMP and cell death, demonstrated in human embryonic kidney (HEK) cells. Our research extended beyond zinc-induced neurotoxicity, as we observed EGF’s protective effects against other oxidative stressors linked to intracellular zinc release, including hydrogen peroxide (H2O2) and 1-methyl-4-phenylpyridinium ion (MPP+). Collectively, our findings unveil the intricate interplay between EGF-triggered EGFR endocytosis, lysosomal upregulation, an increase in the regulatory capacity for zinc homeostasis, and the subsequent alleviation of zinc-induced neurotoxicity. These results present promising avenues for therapeutic interventions to enhance neuroprotection by targeting lysosomal augmentation.
The influence mechanism of Real-Time Online Education Platform on Learner User Behavior
Authors: Mei Siyang , She Shengxiang , Liu Xin , Li Feng 
Published: January 2024

Abstract

The global outbreak of COVID-19 has triggered revolutionary changes in the field of education, especially the rise of real-time online education platform. The purpose of this paper is to explore the reasons of learner users' satisfaction and how to influence the willingness to continue using. Firstly, this paper combines the success model of information systems to construct a model of influencing factors of learner users' satisfaction about real-time online education platforms. Secondly, a questionnaire survey was conducted on 670 learners of China's real-time online education platform, then the structural equation model was used to analyze the main influencing factors of learners' satisfaction and how to influence the willingness to continue using real-time online education platform. The paper found that the professionalism and honesty of teacher quality, the usefulness, abundance, and appropriateness of content quality, as well as the technical and convenient feature of platform quality that predicted learner satisfaction, which has a positive impact on the willingness to continue using. The research provided a series of design strategies and improvement suggestions to improve the learner experience of real-time online education platform.
Women’s influence on adaptation strategies when fisheries change
Authors: Nakamura Katrina , Kuchepatov Julie 
Published: January 2024

Abstract

Women play central roles in fish industries and in adaptation strategies when fisheries change. Yet, the methods and approaches taken by women are not well-clarified or acknowledged with the result that, when fisheries change, fisheries policies and programs can be ill-equipped. We applied a gender lens to adaptation strategies in fisheries by surveying Fishery Improvement Project implementers across the aquatic value chain and comparing changes in fishery governance. Project implementers enumerated 100 fishery roles and described multiple forms of leadership by women fishers, cooperative representatives, harvest agents, primary processors, domestic partners of fishers, community fisher representatives and quality assurance technicians. Projects led by women (self-identified) had stronger scores for fisheries governance with 71% showing positive score increases since the project began as compared to 23% in the reference population. Key factors in successful fisheries adaptation were field data collection and time spent with local stakeholders over changes in the fishery. However, localized initiatives by women that did not fit easily into project templates went unrecognized by funders with the result that field work crucial to successful adaptation was being performed with voluntary labour at unsustainable levels. Investments in social capital and in women’s leadership at all levels of decision-making appear crucial to successful adaptation in fisheries.
Clinical Outcomes and Prognostic Factors of Concurrent Chemoradiotherapy for Anal Squamous Cell Carcinoma in Japan
Authors: Takahashi Ryo , Osumi Hiroki , Wakatsuki Takeru , Yamamoto Noriko , Taguchi Senzo , Nakayama Izuma , Ooki Akira , Ogura Mariko , Takahari Daisuke , Chin Keisho , Yamaguchi Kensei , Shinozaki Eiji 
Published: January 2024

Abstract

Background
Concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregional anal squamous cell carcinoma (ASCC) in Western countries. However, there have been few reports on the clinical outcomes of CCRT in Japan. This study aimed to evaluate the clinical outcomes of CCRT, prognostic factors, and the clinical impact of programmed cell death-ligand 1 (PD-L1) expression of ASCC in Japan.
Methods
Patients with locoregional ASCC were enrolled between 2007 and 2017. All patients received CCRT consisting of ≥ 45 Gy of radiation, 5-fluorouracil, and mitomycin C. Disease-free survival (DFS), overall survival (OS), and adverse events (AEs) were estimated. The expression of p16 and PD-L1 was evaluated using immunohistochemical staining (IHC).
Results
This study included 36 patients, of whom 30 (83.3%) were female. Among the participants, 32 (88.9%) achieved complete clinical remission, while six (16.7%) experienced recurrence. The five-year DFS and five-year OS were 72.2% and 84.7%, respectively. Major AEs of grades ≥ 3 included neutropenia in 10 (27.7%) and perianal dermatitis in eight (22.2%). In a univariate analysis, male sex, lymph node metastasis, and large tumor size were significantly associated with worse outcomes. In a multivariate analysis, tumor size was an independent factor related to short DFS. Of the 30 patients whose biopsy specimens were available for IHC, 29 (96.7%) were positive for p16, and 13 (43.3%) were positive for PD-L1. However, PD-L1 expression did not show any clinical impact.
Conclusions
The comparative etiology, clinical outcomes, and prognostic factors of CCRT observed in Japanese patients with locoregional ASCC were consistent with Western data.
Molecular cloning and functional analysis of ScHAK10 gene promoter from sugarcane (Saccharum officinarum L.)
Authors: Luo Hai-Bin , Huang Cheng-Mei , Cao Hui-Qing , Xu Lin , Wu Kai-Chao , Deng Zhi-Nian , Wu Xing-Jian , Ye Li-Ping , Yi Xiao-Ping , Wei Yuan-Wen 
Published: January 2024

Abstract
Transcriptional regulation of the high-affinity K+ (HAK) transporter gene is an important mechanism of plant response to low potassium stress. Cloning and analysis of the promoter of potassium transporter gene is not only helpful to its expression pattern and regulation mechanism but also important to improve the potassium absorption efficiency in sugarcane. The potassium transporter gene ScHAK10 is highly expressed and induced by low potassium stress in sugarcane，but the functions of its promoter is still unclear. In the present article, the 1918 bp promoter region of the ScHAK10 gene (pScHAK10) was cloned by genomic walking technique. Computational analysis affirmed the existence of abiotic stress-responsive cis and core cis-elements, such as TATA box, CAAT box, phytohormone responsive, stress response and light response motifs. GUS histochemical staining of transgenic Arabidopsis thaliana seedlings showed that the leaf, corolla, and root tip were deeply stained, and paraffin sections of root tip tissue showed GUS staining in ductal tissue of A. thaliana shallowly stained. The 5′-terminal deletion of the promoter was cloned, and the lengths of 1918 (full), 1623 (Q1), 1332 (Q2), 957 (Q3), 576 (Q4), and 357 bp (Q5) were cloned into the GUS reporter vector for A. thaliana transient transformation. The transgenic plants generated through a single event exhibited a promising expression of the GUS reporter protein, which was treated with salt, low potassium, IAA and cold stress conditions. The results showed that the promoter activity correlates with the promoter fragment's length, and the long promoter fragment exhibits higher training. The Q5 was the least active and could not drive GUS expression. Under abiotic stress, the expression of GUS enzyme activity varies among different promoter fragments. Under low potassium and high salt stress, Q3 and Q4 showed the highest promoter activity. The Q1 and Q4 led the highest promoter activity during IAA and cold stress. These findings help to understand the molecular mechanism of ScHAK10 expression regulation and provide a theoretical basis for improving potassium uptake efficiency and breeding potassium-efficient varieties in sugarcane.
Advancing Public Health through Technological Rehabilitation: Insights from a National Clinician Survey
Authors: Capecci Marianna , Gandolfi Marialuisa , Straudi Sofia , Calabrò Rocco Salvatore , Baldini Nicolò , Pepa Lucia , Andrenelli Elisa , Smania Nicola , Ceravolo Maria Gabriella , Morone Giovanni , Bonaiuti Donatella 
Published: January 2024

Abstract

Introduction: In the evolving healthcare landscape, technology has emerged as a key component in enhancing system efficiency and offering new avenues for patient rehabilitation. Despite its growing importance, detailed information on technology's specific use, types, and applications in clinical rehabilitation settings, particularly within the Italian framework, remains unclear. This study aimed to explore the use of technology and its needs by Physical Medicine and Rehabilitation medical doctors in Italy. Methods: We conducted a cross-sectional online survey aimed at 186 Italian clinicians affiliated with the Italian Society of Physical and Rehabilitation Medicine (SIMFER). The online questionnaire consists of 71 structured questions designed to collect demographic and geographical data of the respondents, as well as detailed insights into the prevalence and range of technologies they use, together with their specific applications in clinical settings." Results: A broad range of technologies, predominantly commercial medical devices, has been documented. These technologies are employed for various conditions, including common neurological diseases, musculoskeletal disorders, dementia, and rheumatologic issues. The application of these technologies indicates a broadening scope beyond enhancing sensorimotor functions, addressing both physical and social aspects of patient care. Discussion: In recent years, there's been a notable surge in using technology for rehabilitation across various disorders. The upcoming challenge is to update health policies to integrate these technologies better, aiming to extend their benefits to a wider range of disabling conditions, marking a progressive shift in public health and rehabilitation practices.