bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Signage: Toward a Transformative Model that Effectively Generates Consumer-Product Relationships
Authors: Velasco Franklin , Marriott Hanna 
Published: October 2023

AbstractSmart signage moves beyond traditional signage as it combines digital displays with Artificial Intelligence processes, Machine Learning attributes, and the use of Internet of Things consumer data. This chapter develops a conceptual model that illustrates both the dynamic nature of smart signs in retail contexts and the factors that coexist when consumers interact with this novel marketing communication tool. A set of new concepts and relationships are included in the model to reflect how smart signs two-way communication interface, technological characteristics, effects of psychological mechanism and privacy concerns, and formation of consumer-product relationships, all of which are useful in understanding smart signage persuasion effects. We foresee a fruitful avenue for research in the domain of smart signage and we discuss several implications for retail marketing, consumer wellbeing, and shopping experiences.
Consumer Trust and Platformised Retail Personalisation
Authors: Larsson Stefan , Haresamudram Kashyap 
Published: October 2023

AbstractAs retail is becoming increasingly digitised in its operation and consumer relationships, much faith is being put into automation, prediction, and insights drawn from consumer data to shape consumer experiences and expectations. Under the umbrella of data collection and artificial intelligence (AI), this chapter studies the role of consumer trust in retail personalisation. We draw empirical insights from focus-group interviews conducted with Swedish consumers regarding three main aspects: (1) consumer sentiment on data collection; (2) data-dependent retail personalisation; and (3) the digitised market logic that follows from platformisation. Firstly, the results indicate that the level of trust that consumers have in general for data collection is of relevance to how successful retailers’ use of recommendations systems and targeted ads will be. Secondly, and echoing earlier studies, user agreements and privacy notices are something that most interviewees find hard to comprehend and pay attention to. Thirdly, data collection, automation, and personalisation are often third-party dependent and platformised. To consumers, this adds to a lack of transparency and a sense of losing control of their data, which should be taken as a call to action as regards retailers being more attentive to consumer trust and avoiding third-party sharing to the extent it is possible.
Vertrauen in Journalismus
Authors: Körner Theresa 
Published: October 2023

ZusammenfassungVertrauen ist – neben dem automatisierten Journalismus – der zweite wesentliche Begriff dieser Arbeit. Das Kapitel soll die Vertrauensforschung der Kommunikationswissenschaft aufarbeiten und die zentralen Punkte aus der Theorie für das Forschungsanliegen herausstellen. Dazu wird zunächst dargelegt, warum Vertrauen der zentrale Begriff dieser Arbeit ist und nicht das Glaubwürdigkeitskonzept aus dem Forschungsstand weitergeführt wird. Danach werden die Grundlagen des Vertrauensbegriffs, wesentliche Definitionen, die Operationalisierung verschiedener Medienvertrauensbeziehungen sowie bisher ermittelte Einflussfaktoren für Medienvertrauen angesprochen. Das Kapitel endet mit der Aufbereitung empirischer Daten zum aktuellen Stand des Journalismusvertrauens in Deutschland.
CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice
Authors: Bosch Angela J. T. , Keller Lena , Steiger Laura , Rohm Theresa V. , Wiedemann Sophia J. , Low Andy J. Y. , Stawiski Marc , Rachid Leila , Roux Julien , Konrad Daniel , Wueest Stephan , Tugues Sonia , Greter Melanie , Böni-Schnetzler Marianne , Meier Daniel T. , Cavelti-Weder Claudia 
Published: October 2023

Abstract
Aims/hypothesis
Colony stimulating factor 1 (CSF1) promotes the proliferation, differentiation and survival of macrophages, which have been implicated in both beneficial and detrimental effects on glucose metabolism. However, the physiological role of CSF1 signalling in glucose homeostasis and the potential therapeutic implications of modulating this pathway are not known. We aimed to study the composition of tissue macrophages (and other immune cells) following CSF1 receptor (CSF1R) inhibition and elucidate the metabolic consequences of CSF1R inhibition.

Methods
We assessed immune cell populations in various organs by flow cytometry, and tissue-specific metabolic effects by hyperinsulinaemic–euglycaemic clamps and insulin secretion assays in mice fed a chow diet containing PLX5622 (a CSF1R inhibitor) or a control diet.

Results
CSF1R inhibition depleted macrophages in multiple tissues while simultaneously increasing eosinophils and group 2 innate lymphoid cells. These immunological changes were consistent across different organs and were sex independent and reversible after cessation of the PLX5622. CSF1R inhibition improved hepatic insulin sensitivity but concomitantly impaired insulin secretion. In healthy islets, we found a high frequency of IL-1β+ islet macrophages. Their depletion by CSF1R inhibition led to downregulation of macrophage-related pathways and mediators of cytokine activity, including Nlrp3, suggesting IL-1β as a candidate insulin secretagogue. Partial restoration of physiological insulin secretion was achieved by injecting recombinant IL-1β prior to glucose stimulation in mice lacking macrophages.

Conclusions/interpretation
Macrophages and macrophage-derived factors, such as IL-1β, play an important role in physiological insulin secretion. A better understanding of the tissue-specific effects of CSF1R inhibition on immune cells and glucose homeostasis is crucial for the development of targeted immune-modulatory treatments in metabolic disease.

Data availability
The RNA-Seq dataset is available in the Gene Expression Omnibus (GEO) under the accession number GSE189434 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE189434).

Graphical Abstract
Increased TT–TG distance caused by excessive tibiofemoral rotation predicts poor clinical outcomes after tibial tubercle osteotomy in recurrent patellar dislocation
Authors: Zhang Zhi‐jun , Feng Zheng , Di Menglinqian , Cao Yan‐wei , Zheng Tong , Zhang Hui 
Published: October 2023

AbstractPurposeTo compare clinical outcome between recurrent patellar dislocation (RPD) with or without actual tibial tubercle lateralisation (TTL) after medial patellofemoral ligament reconstruction (MPFL‐R) combined with tibial tubercle transfer.MethodsFrom 2015 to 2018, a total of 172 knees with RPD and a tibial tubercle–trochlear groove (TT–TG) distance of > 20 mm were treated with MPFL‐R combined with tibial tubercle transfer. Patients were divided into the lateralisation group (TT–PCL > 24 mm, n = 74) and the nonlateralisation group (TT–PCL ≤ 24 mm, n = 60) based on the presence or absence of actual TTL (TT–PCL > 24 mm). Clinical outcomes were assessed postoperatively at a minimum of 2 years. Second‐look arthroscopic evaluations were available for 84 knees to assess cartilage damage.ResultsA total of 134 knees with a median follow‐up time of 32 months were included. Tibiofemoral rotation (TFR) was significantly higher in the nonlateralisation group than in the lateralisation group (15.4° vs. 9.4°, P < 0.001). At the final follow‐up, the nonlateralisation group had significantly lower Kujala (78.2 vs. 86.4, P = 0.001) and Lysholm (80.3 vs. 88.2, P = 0.003) scores than the lateralisation group. At the time of the second‐look arthroscopic assessment, 38.9% of the patients in the nonlateralisation group showed cartilage worsening in the medial patellar facet that was significantly higher than that in the lateralisation group (38.9% vs. 12.5%, P = 0.015).ConclusionPatients with RPD and an increased TT–TG distance of > 20 mm but without actual tibial tubercle lateralisation benefit less from tibial tubercle transfer than patients with actual tibial tubercle lateralisation, which may be related to the significantly higher tibiofemoral rotation angle of the former.Level of evidenceIII.
Uncertainty and long-run economy: the role of R &D and business dynamism
Authors: Cieślik Andrzej , Turgut Mehmet Burak 
Published: October 2023

AbstractIn this paper, we study the effects of macroeconomic uncertainty shocks on the US economy in the long-run using an IV-SVAR methodology for the period 1960–2019. Following Piffer and Podstawski (Econ J 128(616):3266–3284, 2018), we use variation in gold prices as an instrument to identify the uncertainty shocks. We find that potential output decreases persistently in response to an uncertainty shock. Furthermore, our study shows that decline in the R &D investments and business dynamism are the two key transmission channels of the uncertainty shocks that generate long lasting effects on the economy.
Clozapine N-oxide, compound 21, and JHU37160 do not influence effortful reward-seeking behavior in mice
Authors: Aomine Yoshiatsu , Oyama Yoshinobu , Sakurai Koki , Macpherson Tom , Ozawa Takaaki , Hikida Takatoshi 
Published: October 2023

Abstract
Rationale
Clozapine N-oxide (CNO) has been developed as a ligand to selectively activate designer receptors exclusively activated by designer drugs (DREADDs). However, previous studies have revealed that peripherally injected CNO is reverse-metabolized into clozapine, which, in addition to activating DREADDs, acts as an antagonist at various neurotransmitter receptors, suggesting potential off-target effects of CNO on animal physiology and behaviors. Recently, second-generation DREADD agonists compound 21 (C21) and JHU37160 (J60) have been developed, but their off-target effects are not fully understood.

Objectives
The present studies assessed the effect of novel DREADD ligands on reward-seeking behavior.

Methods
We first tested the possible effect of acute i.p. injection of low-to-moderate (0.1, 0.3, 1, 3 mg/kg) of CNO, C21, and J60 on motivated reward-seeking behavior in wild-type mice. We then examined whether a high dose (10 mg/kg) of these drugs might be able to alter responding.

Results
Low-to-moderate doses of all drugs and a high dose of CNO or C21 did not alter operant lick responding for a reward under a progressive ratio schedule of reinforcement, in which the number of operant lick responses to obtain a reward increases after each reward collection. However, high-dose J60 resulted in a total lack of responding that was later observed in an open field arena to be due to a sedative effect.

Conclusions
This study provides definitive evidence that commonly used doses of CNO, C21, and J60 have negligible off-target effects on motivated reward-seeking but urges caution when using high doses of J60 due to sedative effects.
Die Verordnung (EU) 2017/746 (IVDR) in der Praxis: Umsetzung von Anhang I in der Pathologie
Authors: Kahles Andy , Goldschmid Hannah , Volckmar Anna-Lena , Ploeger Carolin , Kazdal Daniel , Penzel Roland , Budczies Jan , Flechtenmacher Christa , Gassner Ulrich M. , Brüggemann Monika , Vogeser Michael , Schirmacher Peter , Stenzinger Albrecht 
Published: October 2023

Zusammenfassung
Hintergrund
Die Verordnung (EU) 2017/746 über In-vitro-Diagnostika (IVDR) stellt mehrere Bedingungen an Pathologische Institute, die hausinterne In-vitro-Diagnostika (IH-IVD) entwickeln und anwenden. Diese Bedingungen müssen jedoch nicht alle unmittelbar mit dem Geltungsbeginn der IVDR zum 26.05.2022 umgesetzt worden sein. Auf der Grundlage einer Änderungsverordnung des Europäischen Parlaments und des Rates der Europäischen Union werden die Anforderungen an IH-IVD stufenweise eingeführt. Die Konformität mit den grundlegenden Sicherheits- und Leistungsanforderungen gemäß Anhang I muss seit Mai 2022 gewährleistet sein

Ziel der Arbeit
Mit diesem Artikel möchten wir die praktische Umsetzung der aktuell gültigen Bedingungen für IH-IVD im Pathologischen Institut des Universitätsklinikums Heidelberg vorstellen und damit mögliche Hilfestellung für andere Einrichtungen geben

Schlussfolgerungen
Neben der intensiven Auseinandersetzung mit den Anforderungen an IH-IVD geben mehrere Handreichungen und Hilfestellungen eine Orientierungshilfe zur Umsetzung und Harmonisierung der in Artikel 5 (5) genannten Anforderungen an Gesundheitseinrichtungen. Auch der Austausch in akademischen Netzwerkstrukturen ist für die Interpretation und die praktische Umsetzung der IVDR von großer Bedeutung. Für universitäre und nicht-universitäre Einrichtungen stellt die Sicherstellung der IVDR-Konformität – neben den wesentlichen Aufgaben in der Krankenversorgung, in der Lehre und der Forschung und Weiterentwicklung von Methoden zur optimalen und zielgerichteten Diagnostik sowie der Aufrechterhaltung des sich stetig weiterentwickelnden Qualitätsmanagementsystems – eine weitere personelle und zeitliche Herausforderung dar.
Technological advance, social fragmentation and welfare
Authors: Bosworth Steven J. , Snower Dennis J. 
Published: October 2023

AbstractThis paper models the welfare consequences of social fragmentation arising from technological advance. We start from the premise that technological progress falls primarily on market-traded commodities rather than prosocial relationships, since the latter intrinsically require the expenditure of time and thus are less amenable to productivity increases. Since prosocial relationships require individuals to identify with others in their social group whereas marketable commodities are commonly the objects of social status comparisons, a tradeoff arises between in-group affiliation and inter-group status comparisons. People consequently narrow the bounds of their social groups, reducing their prosocial relationships and extending their status-seeking activities. As prosocial relationships generate positive externalities whereas status-seeking activities generate negative preference externalities, technological advance may lead to a particular type of “decoupling” of social welfare from material prosperity. Once the share of status goods in total production exceeds a crucial threshold, technological advance is shown to be welfare-reducing.
Geographic access to pediatric neurosurgeons in the USA: an analysis of sociodemographic factors
Authors: Farivar Daniel , Peterman Nicholas J. , Narendran Nakul , Illingworth Kenneth D. , Nuckols Teryl K. , Bonda David , Skaggs David L. 
Published: October 2023

Abstract
Purpose
Geographic access to physicians has been shown to be unevenly distributed in the USA, with those in closer proximity having superior outcomes. The purpose of this study was to describe how geographic access to pediatric neurosurgeons varies across socioeconomic and demographic factors.

Methods
Actively practicing neurosurgeons were identified by matching several registries and membership logs. This data was used to find their primary practice locations and the distance the average person in a county must travel to visit a surgeon. Counties were categorized into “surgeon deserts” and “surgeon clusters,” which were counties where providers were significantly further or closer to its residents, respectively, compared to the national average. These groups were also compared for differences in population characteristics using data obtained from the 2020 American Community Survey.

Results
A total of 439 pediatric neurosurgeons were identified. The average person in a surgeon desert and cluster was found to be 189.2 ± 78.1 miles and 39.7 ± 19.6 miles away from the nearest pediatric neurosurgeon, respectively. Multivariate analyses showed that higher Rural–Urban Continuum (RUC) codes (p < 0.001), and higher percentages of American Indian (p < 0.001) and Hispanic (p < 0.001) residents were independently associated with counties where the average person traveled significantly further to surgeons.

Conclusion
Patients residing in counties with greater RUC codes and higher percentages of American Indian and Hispanic residents on average need to travel significantly greater distances to access pediatric neurosurgeons.
Factors associated with intrachoroidal cavitation and sinkhole formation in eyes with glaucomatous visual-field defects
Authors: Yamaguchi Chiaki , Kiyota Naoki , Takahashi Naoki , Takeda Yoko , Omodaka Kazuko , Tsuda Satoru , Nakazawa Toru 
Published: October 2023

Abstract
Purpose
To investigate factors associated with intrachoroidal cavitation (ICC) and sinkhole formation in eyes with glaucomatous visual-field defects.

Methods
This retrospective, cross-sectional study enrolled a total of 2808 eyes of 1482 patients who were diagnosed/treated for glaucoma and underwent swept-source optical coherence tomography (OCT). We first determined the prevalence of ICCs and sinkholes and their locations. Next, we selected one eye from each patient and compared the clinical characteristics of eyes with and without ICCs. Finally, in eyes with ICCs, we compared the clinical characteristics of eyes with and without sinkholes. Blood flow (BF), represented by laser speckle flowgraphy–measured tissue-area mean blur rate (MBR), was measured in the temporal optic nerve head (ONH), temporal peripapillary chorioretinal atrophy (PPA) zone, and in the ICC zone. ICC area and angle were analyzed in OCT en-face images. Mean deviation and total deviation in the central area (TD-central) were measured with Humphrey visual-field testing.

Results
A total of 86 eyes (3.1%) had ICCs and 52 eyes (1.9%) had sinkholes. ICC eyes had a lower spherical equivalent and longer axial length (AL) than non-ICC eyes (P < 0.05). Patients with eyes with sinkholes were more elderly and had worse best-corrected visual acuity, worse TD-central, a larger ICC, and lower tissue-area MBR in the temporal ONH, temporal PPA zone, and ICC zone (P < 0.05).

Conclusion
In eyes with glaucoma, AL elongation might be linked to ICC formation. Sinkhole formation might be associated with ICC enlargement, impaired ocular BF, and impaired retinal structure and function involving the central area.
Escape of surgical smoke particles, comparing conventional and valveless trocar systems
Authors: Robertson Daniel , Sterke Frank , van Weteringen Willem , Arezzo Alberto , Mintz Yoav ,   The Technology Committee of the European Association for Endoscopic Surgery (EAES), Boni Luigi , Baldari Ludovica , Chand Manish , Fuchs Hans , Ficuciello Fanny , Marconi Stefania , Mylonas George , Kim Young Woo , Nakajima Kiyokazu , Schijven Marlies , Valdastri Pietro , Sagiv Chen , Mascagni Pietro , Myśliwiec Piotr , Petz Wanda , Sánchez-Margallo Francisco , Horeman Tim 
Published: October 2023

Abstract
Background
During minimal access surgery, surgical smoke is produced which can potentially be inhaled by the surgical team, leading to several health risks. This smoke can escape from the abdominal cavity into the operating room due to trocar leakage. The trocars and insufflator that are used during surgery influence gas leakage. Therefore, this study compares particle escape from a valveless (Conmed AirSeal iFS), and a conventional (Karl Storz Endoflator) system.

Materials and methods
Using an in vitro model, a conventional and a valveless trocar system were compared. A protocol that simulated various surgical phases was defined to assess the surgical conditions and particle leakage. Insufflation pressures and instrument diameters were varied as these are known to affect gas leakage.

Results
The conventional trocar leaked during two distinct phases. Removal of the obturator caused a sudden release of particles. During instrument insertion, an average of 211 (IQR 111) particles per second escaped when using the 5 mm diameter instrument. With the 10 mm instrument, 50 (IQR 13) particles per second were measured. With the conventional trocar, a higher abdominal pressure increased particle leakage. The valveless trocar demonstrated a continuously high particle release during all phases. After the obturator was removed, particle escape increased sharply. Particle escape decreased to 1276 (IQR 580) particles per second for the 5 mm instrument insertion, and 1084 (IQR 630) particles per second for 10 mm instrument insertion. With the valveless trocar system, a higher insufflation pressure lowered particle escape.

Conclusions
This study shows that a valveless trocar system releases more particles into the operating room environment than a conventional trocar. During instrument insertion, the leakage through the valveless system is 6 to 20 times higher than the conventional system. With a valveless trocar, leakage decreases with increasing pressure. With both trocar types leakage depends on instrument diameter.
Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference
Authors: Starr Michelle C. , Barreto Erin , Charlton Jennifer , Vega Molly , Brophy Patrick D. , Ray Bignall O. N. , Sutherland Scott M. , Menon Shina , Devarajan Prasad , Akcan Arikan Ayse , Basu Rajit , Goldstein Stuart , Soranno Danielle E. ,   the ADQI 26 workgroup
Published: October 2023

Abstract
Background
In the past decade, there have been substantial advances in our understanding of the pathobiology of pediatric acute kidney injury (AKI). In particular, animal models and studies focused on the relationship between kidney development, nephron number, and kidney health have identified a number of heterogeneous pathophysiologies underlying AKI. Despite this progress, gaps remain in our understanding of the pathobiology of pediatric AKI.

Methods
During the 26th Acute Disease Quality Initiative (ADQI) Consensus conference, a multidisciplinary group of experts discussed the evidence and used a modified Delphi process to achieve consensus on recommendations for opportunities to advance translational research in pediatric AKI. The current state of research understanding as well as gaps and opportunities for advancement in research was discussed, and recommendations were summarized.

Results
Consensus was reached that to improve translational pediatric AKI advancements, diverse teams spanning pre-clinical to epidemiological scientists must work in concert together and that results must be shared with the community we serve with patient involvement. Public and private research support and meaningful partnerships with adult research efforts are required. Particular focus is warranted to investigate the pediatric nuances of AKI, including the effect of development as a biological variable on AKI incidence, severity, and outcomes.

Conclusions
Although AKI is common and associated with significant morbidity, the biologic basis of the disease spectrum throughout varying nephron developmental stages remains poorly understood. An incomplete understanding of factors contributing to kidney health, the diverse pathobiologies underlying AKI in children, and the historically siloed approach to research limit advances in the field. The recommendations outlined herein identify gaps and outline a strategic approach to advance the field of pediatric AKI via multidisciplinary translational research.