bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Tata Letak Toko Retail Mandirimart di Kota Bogor
Authors: Hofipah Opi , Muhammad Adriel Nouval , Fidelia Indi , Andrian Alfin , Kamil Bariz Insan 
Published: October 2023

Tata letak merupakan suatu hal yang mendasar untuk tercapainya efisiensi, sehingga dapat membantu suatu perusahaan menetapkan daya saing perusahaan dalam menentukan fleksibilitas, kapasitas, proses juga kualitas kerja, kontak dengan pembeli dan citra perusahaan. Berdasarkan pengamatan yang sudah dilakukan bahwa ada yang beberapa yang perlu diperbaiki dalam segi tata letak. Seperti kurang nya beberapa bagian yang cukup penting untuk berada dalam toko retail sehingga menyebabkan ketidaksesuaian display produk, sehingga dirasa tidak efisien maka dari itu diperlukan perencanaan ulang terhadap toko Mandirimart menggunakan metode analisis Activity Relationship Chart (ARC) dan (TCR) Total Closeness Rating maka didapatkan hasil tertinggi yaitu kasir sebesar 169 berupa keterangan A yang berarti kedekatan absolut atau sangat penting. Metode analisis tersebut digunakan pada penelitian ini dikarenakan dapat mengetahui hubungan dan keterkaitan dari suatu ruangan ke ruangan lainnya, juga mempermudah untuk mengambil pilihan atau keputusan yang tepat pada layout solution.

Kata Kunci : Tata Letak, ARC, TCR
Analisis Minimalisasi Biaya Antibiotik Pada Pasien Pneumonia Di RSUD Sultan Suriansyah Banjarmasin Periode Januari-Desember 2021
Authors: Agustina Desy , Aryzki Saftia , Rahman Subhannur 
Published: October 2023

Latar belakang:Pneumonia merupakan infeksi parenkim paru akut yang menjadi penyakit penyebab kematian kedua pada anak setelah diare. Biaya pengobatan antibiotik pada pneumonia anak pada tahun 2015 diperkirkan US$109 juta pertahun. Perbedaan biaya pada antibiotik serta biaya lainnya yang dikeluarkan pasien menyebabkan perlunya analisis farmakoekonomi dengan metode analisis minimalisasi biaya
Tujuan:Penelitian ini bertujuan untuk mengetahui terapi antibiotik yang minimal pada pasien pneumonia balita di RSUD Sultan Suriansyah Banjarmasin antara ampicillin dan ceftriaxon .
Metode:Penelitan retrospektif dengan rancangan penelitian Cross Sectional melalui rekam medik dan rincian pembiayaan pasien pada periode Januari - Desember 2021. Analisis data statistik yang digunakan adalah uji Independent T-Test dan Mann Whitney. Jumlah sampel dalam penelitian yaitu sebesar 33 pasien pneumonia pada balita dengan usia 0-10 tahun
Hasil:Hasil penelitan untuk rata-rata total biaya perawatan pasien selama rawat inap dengan karakteristik biaya pasien meliputi biaya obat, biaya rawat inap, biaya visite dokter, biaya konsultasi, biaya pelayanan gizi, biaya tindakan keperawatn dan biaya penunjang lainnya adalah Rp 1.872.469 untuk ampicillin dan Rp 1.709.564 untuk ceftraixon dengan nilai p < 0.05 untuk biaya obat yang berarti ada perbedaan signifikan sedangkan biaya lainnya memiliki p > 0.05 yang memiliki arti tidak ada perbedaan signifikan antara kedua obat tersebut
Kesimpulan:Terapi antibiotik yang minimal pada pengobatan pneumonia anak rawat inap adalah ceftriaxone dengan rata-rata biaya Rp 1.709.564 dibandingjan engan ampicilim yaitu dengan total rata-rata Rp 1.872.469 dan terdapat perbedaan biaya yang signifikan dianatara kedua obat tersebut.

Kata Kunci:Ampicilin, Analisis Minimalisasi Biaya, Ceftriaxon, Pneumonia Balita
Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells
Authors: Singh Vikash , Walter Vonn , Elcheva Irina , Imamura Kawasawa Yuka , Spiegelman Vladimir S. 
Published: October 2023

Graphical AbstractExploring the post-transcriptional regulation of three categories of Wnt/β-Catenin signaling target genes by IGF2BP1. Created with BioRender.com.
The causal relationship between air pollution, obesity, and COVID-19 risk: a large-scale genetic correlation study
Authors: Zhang Jingwei , Wen Jie , Wan Xin , Luo Peng 
Published: October 2023

ObjectiveObservational evidence reported that air pollution is a significant risk element for numerous health problems, such as obesity and coronavirus disease 2019 (COVID-19), but their causal relationship is currently unknown. Our objective was to probe the causal relationship between air pollution, obesity, and COVID-19 and to explore whether obesity mediates this association.MethodsWe obtained instrumental variables strongly correlated to air pollutants [PM2.5, nitrogen dioxide (NO2) and nitrogen oxides (NOx)], 9 obesity-related traits (abdominal subcutaneous adipose tissue volume, waist-to-hip ratio, body mass index, hip circumference, waist circumference, obesity class 1-3, visceral adipose tissue volume), and COVID-19 phenotypes (susceptibility, hospitalization, severity) from public genome-wide association studies. We used clinical and genetic data from different public biological databases and performed analysis by two-sample and two-step Mendelian randomization.ResultsPM2.5 genetically correlated with 5 obesity-related traits, which obesity class 1 was most affected (beta = 0.38, 95% CI = 0.11 - 0.65, p = 6.31E-3). NO2 genetically correlated with 3 obesity-related traits, which obesity class 1 was also most affected (beta = 0.33, 95% CI = 0.055 - 0.61, p = 1.90E-2). NOx genetically correlated with 7 obesity-related traits, which obesity class 3 was most affected (beta = 1.16, 95% CI = 0.42-1.90, p = 2.10E-3). Almost all the obesity-related traits genetically increased the risks for COVID-19 phenotypes. Among them, body mass index, waist circumference, hip circumference, waist-to-hip ratio, and obesity class 1 and 2 mediated the effects of air pollutants on COVID-19 risks (p &lt; 0.05). However, no direct causal relationship was observed between air pollution and COVID-19.ConclusionOur study suggested that exposure to heavy air pollutants causally increased risks for obesity. Besides, obesity causally increased the risks for COVID-19 phenotypes. Attention needs to be paid to weight status for the population who suffer from heavy air pollution, as they are more likely to be susceptible and vulnerable to COVID-19.
Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal
Authors: Gervais Nicole J. , Gravelsins Laura , Brown Alana , Reuben Rebekah , Perovic Mateja , Karkaby Laurice , Nicoll Gina , Laird Kazakao , Ramana Shreeyaa , Bernardini Marcus Q. , Jacobson Michelle , Velsher Lea , Foulkes William , Rajah M. Natasha , Olsen Rosanna K. , Grady Cheryl , Einstein Gillian 
Published: October 2023

IntroductionWomen with early ovarian removal (&lt;48 years) have an elevated risk for both late-life Alzheimer’s disease (AD) and insomnia, a modifiable risk factor. In early midlife, they also show reduced verbal episodic memory and hippocampal volume. Whether these reductions correlate with a sleep phenotype consistent with insomnia risk remains unexplored. MethodsWe recruited thirty-one younger middleaged women with risk-reducing early bilateral salpingo-oophorectomy (BSO), fifteen of whom were taking estradiol-based hormone replacement therapy (BSO+ERT) and sixteen who were not (BSO). Fourteen age-matched premenopausal (AMC) and seventeen spontaneously peri-postmenopausal (SM) women who were ~10y older and not taking ERT were also enrolled. Overnight polysomnography recordings were collected at participants’ home across multiple nights (M=2.38 SEM=0.19), along with subjective sleep quality and hot flash ratings. In addition to group comparisons on sleep measures, associations with verbal episodic memory and medial temporal lobe volume were assessed. ResultsIncreased sleep latency and decreased sleep efficiency were observed on polysomnography recordings of those not taking ERT, consistent with insomnia symptoms. This phenotype was also observed in the older women in SM, implicating ovarian hormone loss. Further, sleep latency was associated with more forgetting on the paragraph recall task, previously shown to be altered in women with early BSO. Both increased sleep latency and reduced sleep efficiency were associated with smaller anterolateral entorhinal cortex volume. DiscussionTogether, these findings confirm an association between ovarian hormone loss and insomnia symptoms, and importantly, identify an younger onset age in women with early ovarian removal, which may contribute to poorer cognitive and brain outcomes in these women.
Global research trends in immunotherapy for glioma: a comprehensive visualization and bibliometric analysis
Authors: Zhang Hong-yu , Yu Han-yong , Zhao Guo-xu , Jiang Xin-zhan , Gao Ge , Wei Bao-jian 
Published: October 2023

BackgroundGlioma is a prevalent and lethal brain malignancy; despite current treatment options, the prognosis remains poor. Therefore, immunotherapy has emerged as a promising therapeutic strategy. However, research trends and hotspots in glioma immunotherapy have not been systematically analyzed. This study aimed to elucidate global research trends and knowledge structures regarding immunotherapy for glioma using bibliometric analysis.MethodsPublications related to immunotherapy for glioma from 2000-2023 were retrieved from Web of Science Core Collection database (WoSCC). We conducted quantitative analysis and visualization of research trends using various tools, including VOSviewer (1.6.18), CiteSpace (5.7 R3), Microsoft Charticulator, and the Bibliometrix package in R.ResultsA total of 4910 publications were included. The number of annual publications exhibited an obvious upward trend since 2019. The USA was the dominant country in terms of publication output and centrality. Frontiers in Immunology published the most articles. Harvard Medical School ranked first in productivity among institutions. Sampson, John H. Ph.D. is the most prolific author in the field with 88 articles and a total of 7055 citations. Clinical Cancer Research has the largest total number and impact factor. Analysis of keywords showed immunotherapy, glioblastoma, immunotherapy, and clinical trials as hot topics. The tumor microenvironment, cell death pathways, chimeric antigen receptor engineering, tumor-associated macrophages, and nivolumab treatment represent indicating shifts in the direction of future glioma immunotherapy development.ConclusionThis bibliometric analysis systematically delineated global landscapes and emerging trends in glioma immunotherapy research. This study highlighted the prominence of Chimeric Antigen Receptor T-cell (CAR-T), Programmed Death-1 (PD-1), and nivolumab in current glioma immunotherapy research. The growing emphasis on specific neoantigens and prognostic tumor markers suggests potential avenues for future exploration. Furthermore, the data underscores the importance of strengthened international collaboration in advancing the field.
Transcriptomic characterization of classical monocytes highlights the involvement of immuno-inflammation in bone erosion in Rheumatoid Arthritis
Authors: Sales Lucas Peixoto , Hounkpe Bidossessi Wilfried , Perez Mariana Ortega , Caparbo Valéria Falco , Domiciano Diogo Souza , Borba Eduardo Ferreira , Schett Georg , Figueiredo Camille Pinto , Pereira Rosa Maria Rodrigues 
Published: October 2023

IntroductionEvidence-based data suggest that under inflammatory conditions, classical monocytes are the main source of osteoclasts and might be involved in bone erosion pathophysiology. Here, we analyze the transcriptomic profile of classical monocytes in erosive and non-erosive rheumatoid arthritis patients in order to better understand their contribution to bone erosion.MethodsThirty-nine premenopausal RA patients were consecutively enrolled and divided into two groups based on the presence of bone erosions on hand joints. Classical monocytes were isolated from peripheral blood through negative selection, and RNA-seq was performed using a poly-A enrichment kit and Illumina® platform. Classical monocytes transcriptome from healthy age-matched women were also included to identify differentially expressed genes (DEGs). Therefore, gene sets analysis was performed to identify the enriched biological pathways.ResultsRNA-seq analysis resulted in the identification of 1,140 DEGs of which 89 were up-regulated and 1,051 down-regulated in RA patients with bone erosion compared to those without bone erosions. Among up-regulated genes, there was a highlighted expression of IL18RAP and KLF14 related to the production of pro-inflammatory cytokines, innate and adaptive immune response. Genes related to collagen metabolism (LARP6) and bone formation process (PAPPA) were down-regulated in RA patients with erosions. Enriched pathways in patients with erosions were associated with greater activation of immune activation, and inflammation. Interestingly, pathways associated with osteoblast differentiation and regulation of Wnt signaling were less activated in RA patients with erosions.ConclusionThese findings suggest that alterations in expression of monocyte genes related to the inflammatory process and impairment of bone formation might have an important role in the pathophysiology of bone erosions in RA patients.
Plasma exchange for two patients with autoimmune GFAP astrocytopathy with rapid progression to respiratory failure: a case report
Authors: Du Jing , Cao Shugang , Xia Lan , Li Qi , Tian Yanghua 
Published: October 2023

BackgroundPatients with autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy can present with early neurological deterioration, but rapidly progressive respiratory failure is rarely reported. We present the cases of two patients with autoimmune GFAP astrocytopathy who experienced rapid progression to respiratory failure and were effectively treated using plasma exchange therapy.Case reportTwo patients were diagnosed with autoimmune GFAP astrocytopathy. Their initial symptoms were consistent with those of previously observed cases of autoimmune GFAP astrocytopathy. However, they experienced rapid progression to respiratory failure due to their lesion location. Specifically, case 1 had lesions in the medulla oblongata, and case 2 had lesions in the high cervical spinal cord, which are both common sites of lesions causing respiratory failure. The patients did not respond well to intravenous methylprednisolone and intravenous immunoglobulin initially and could not be withdrawn from ventilator support. Fortunately, subsequent plasma exchange therapy led to significant clinical improvements and successful withdrawal from ventilator support.DiscussionPatients with autoimmune GFAP astrocytopathy can present with rapidly progressive respiratory failure. Early treatment with plasma exchange can be beneficial in withdrawing patients from ventilator support.
Future Directions in the Diagnosis and Treatment of APDS and IEI: a Survey of German IEI Centers
Authors: Vanselow Sven , Hanitsch Leif , Hauck Fabian , Körholz Julia , Maccari Maria-Elena , Meinhardt Andrea , Sogkas Georgios , Schuetz Catharina , Grimbacher Bodo 
Published: October 2023

IntroductionThe diagnosis and treatment of inborn errors of immunity (IEI) is a major challenge as the individual conditions are rare and often characterized by a variety of symptoms, which are often non disease-specific. Ideally, patients are treated in dedicated centers by physicians who specialize in the management of primary immune disorders. In this study, we used the example of Activated PI3Kδ syndrome (APDS), a rare IEI with an estimated prevalence of 1:1,000,000. We conducted surveys by questionnaire and interviewed physicians at different IEI centers in Germany.MethodsWe queried structural aspects of IEI care in Germany, diagnostic procedures in IEI care (including molecular diagnostics), distribution of APDS patients, APDS symptoms and severity, treatment algorithms in APDS, the role of stem cell transplantation and targeted therapies in IEI with focus on APDS. We were especially interested in how genetic diagnostics may influence treatment decisions, e.g. with regard to targeted therapies.Results/discussionMost centers care for both pediatric and adult patients. A total of 28 APDS patients are currently being treated at the centers we surveyed. Patient journeys vary considerably, as does severity of disease. Genetic diagnosis continues to gain importance - whole genome sequencing is likely to become routine in IEI in the next few years. According to the experts interviewed, stem cell transplantation and - with new molecules being approved - targeted therapies, will gain in importance for the treatment of APDS and IEI in general.
Impact of autologous platelet-rich plasma therapy vs. hyaluronic acid on synovial fluid biomarkers in knee osteoarthritis: a randomized controlled clinical trial
Authors: Li Tianshu , Li Yuefang , Li Wanyue , Wang Xu , Ding Qixin , Gao Jiahuan , Zhang Ying , Zhuang Weisheng 
Published: October 2023

ObjectiveObserve the effects of platelet-rich plasma (PRP) therapy on inflammatory cytokines in the synovial fluid of the knee joint of patients with KOA, and explore the effects of PRP intra-articular injection on the inflammation of the knee joint environment and the possible mechanism of action.MethodsSeventy patients were randomized to undergo three blinded weekly intra-articular injections of PRP or hyaluronic acid (HA). The concentrations of inflammatory cytokines, including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, IL-8, IL-17A, IL-17F, IL-4, IL-5, and IL-10, in the synovial fluid were evaluated before the intervention and 1 month after the third injection. The Western Ontario and McMaster University (WOMAC) and visual analog scale (VAS) scores were used to assess pain and functional status of the knee joints in both groups before the intervention, immediately post-intervention, and 1, 3, 6, and 12 months after the intervention.ResultsBaseline characteristics were similar in both groups with no statistical difference. The IL-6, IL-1β, TNF-α, IL-17A, and IL-10 levels in the synovial fluid of the observation group decreased significantly after, vs. before, the intervention (p &lt; 0.05), whereas the IL-8, IL-17F, and IL-4 levels decreased (p &gt; 0.05) and IL-5 levels increased (p &gt; 0.05). There was no statistically significant difference between inflammatory cytokine levels in the synovial fluid of the samples from the control group before and after the intervention (p &gt; 0.05). There were no statistically significant differences between the two groups immediately after intervention (p &gt; 0.05). At 1, 3, 6, and 12 months after intervention, the WOMAC and VAS scores were significantly better in the observation group than in the control group (p &lt; 0.05).ConclusionPlatelet plasma therapy can reduce the concentrations of inflammatory cytokines IL-6, IL-1β, TNF-α, IL-17A, and IL-10 in the synovial fluid of KOA patients, reduce the expression levels of IL-8, IL-17F, and IL-4, clear the pro-inflammatory factors, improve the inflammatory environment of the affected knee joint, and alleviate pain caused by inflammation. Thus, alleviating pain and improving knee function in patients with KOA.
Maternal supplementation with Limosilactobacillus reuteri FN041 for preventing infants with atopic dermatitis: study protocol for a randomized controlled trial
Authors: Yu Renqiang , Ma Yizhe , Luo Zichen , Qi Ce , Xie Anni , Jiang Yifan , Zhu Baoli , Sun Jin 
Published: October 2023

BackgroundAtopic dermatitis (AD) has increased rapidly with rapid urbanization; however, the treatment options for AD are lacking because the commonly used therapies can only alleviate symptoms. Limosilactobacillus reuteri (L. reuteri), FN041 is a specific strain isolated from human breast milk, and its protective potential against AD has been confirmed. This study aims to assess the efficacy of maternal consumption of L. reuteri FN041 during late pregnancy and lactation in preventing infantile AD.MethodsFirst, a randomized, double-blind, placebo-controlled intervention study will be conducted on 340 pregnant females with babies at high risk for AD. These subjects will be randomly divided into four groups of different doses of L. reuteri FN041 (1 × 109, 5 × 109, and 1 × 1010 CFU/d) along with a placebo. The safety and efficacy of maternal use of L. reuteri FN041 for preventing infantile AD will be analyzed, and the most efficient dosage of L. reuteri FN041 will be determined. Subsequently, a multicenter cohort study of 500 pregnant females with babies at high risk for AD will be conducted to promote the maternal application of L. reuteri FN041. These subjects will be administered L. reuteri FN041 at the optimal dose determined during the first stage of late pregnancy and lactation, and their babies will be analyzed for AD development. Recruitment was initiated in October 2022.DiscussionThe primary outcome is the cumulative incidence of AD at 24 months after maternal consumption of L. reuteri FN041 during late pregnancy and lactation, whereas the secondary outcome is the efficiency of L. reuteri FN041 transfer from the mother’s gut to breast milk and then the infant’s gut after oral supplementation. This study will demonstrate the efficacy of edible probiotics isolated from breast milk in preventing or treating AD in infants. Accordingly, we provide population-based advice for administering specific probiotics for the primary prevention of AD in pregnant females. Understanding the underlying mechanisms of probiotic strains derived from breast milk can promote their application in preventing infant diseases associated with intestinal microbiota imbalance and immune disorders.Clinical trial registrationhttps://www.chictr.org.cn/, identifier [ChiCTR2300075611].
Fabry disease and sleep disorders: a systematic review
Authors: Blaszczyk Bartlomiej , Wieckiewicz Mieszko , Kusztal Mariusz , Michalek-Zrabkowska Monika , Lachowicz Gabriella , Mazur Grzegorz , Martynowicz Helena 
Published: October 2023

BackgroundFabry disease (FD) is an X-chromosome-linked disorder characterized by a reduced or complete absence of the enzyme α-galactosidase, resulting in the accumulation of lysosomal globotriaosylceramide. Despite the presence of these deposits in multiple organs, the problem of sleep disorders within this population has very rarely been documented.ObjectiveThis study aimed to investigate the types and prevalence of sleep disorders among patients with FD.MethodsScreening of the following medical databases using key terms was performed on 10 February 2023: PubMed, Scopus, and Embase. A total of 136 records were identified. The quality assessment of the studies was conducted by using tools from the National Institutes of Health (NIH) and critical appraisal tools from the Joanna Briggs Institute (JBI).ResultsThe study included nine studies on sleep disorders in patients with FD. The overall quality of the majority of these studies was assessed as either poor or fair. Among 330 patients, there was a slightly higher representation of female patients (56%). Sleep problems manifested 4–5 years after the onset of FD and sometimes even after 10–11 years. Genotypes of disease associated with sleep problems were rarely described. Within the FD population, the most commonly reported conditions were excessive daytime sleepiness (EDS) as well as obstructive and central sleep apnea (OSA, CSA). However, EDS occurred more frequently in FD patients, while the prevalence of OSA and CSA was within the ranges observed in the general population. The studies included indicated a lack of association between organ impairment by primary disease and EDS and OSA. The effectiveness of enzyme replacement therapy (ERT) in treating sleep disorders was not demonstrated.ConclusionThe findings of this report revealed the presence of many sleep-related disorders within the FD population. However, very few studies on this subject are available, and their limited results make it difficult to truly assess the real extent of the prevalence of sleep disturbances among these individuals. There is a need to conduct further studies on this topic, involving a larger group of patients. It is important to note that there are no guidelines available for the treatment of sleep disorders in patients with FD.