bluuebunny/crossref_metadata_2025_split huggingface dataset:
A serverless computing architecture for Martian aurora detection with the Emirates Mars Mission
Authors: Pacios David , Vázquez-Poletti José Luis , Dhuri Dattaraj B. , Atri Dimitra , Moreno-Vozmediano Rafael , Lillis Robert J. , Schetakis Nikolaos , Gómez-Sanz Jorge , Iorio Alessio Di , Vázquez Luis 
Published: February 2024

AbstractRemote sensing technologies are experiencing a surge in adoption for monitoring Earth’s environment, demanding more efficient and scalable methods for image analysis. This paper presents a new approach for the Emirates Mars Mission (Hope probe); A serverless computing architecture designed to analyze images of Martian auroras, a key aspect in understanding the Martian atmosphere. Harnessing the power of OpenCV and machine learning algorithms, our architecture offers image classification, object detection, and segmentation in a swift and cost-effective manner. Leveraging the scalability and elasticity of cloud computing, this innovative system is capable of managing high volumes of image data, adapting to fluctuating workloads. This technology, applied to the study of Martian auroras within the HOPE Mission, not only solves a complex problem but also paves the way for future applications in the broad field of remote sensing.
Magmatic-hydrothermal fluid evolution of the tin-polymetallic metallogenic systems from the Weilasituo ore district, Northeast China
Authors: Gao Xu , Zhou Zhenhua , Breiter Karel , Mao Jingwen , Romer Rolf L. , Cook Nigel J. , Holtz François 
Published: February 2024

AbstractThe large Weilasituo Sn-polymetallic deposit is a recent exploration discovery in the southern Great Xing’an Range, northeast China. The ore cluster area shows horizontal mineralization zoning, from the inner granite body outward, consisting of high-T Sn–W–Li mineralization, middle-T Cu–Zn mineralization and peripheral low-T Pb–Zn–Ag mineralization. However, the intrinsic genetic relationship between Sn-W-Li mineralization and peripheral vein-type Pb–Zn–Ag–Cu mineralization, the formation mechanism and the deep geological background are still insufficiently understood. Here, we use fluid inclusions, trace elements concentrations in quartz and sphalerite, and H–O isotope studies to determine the genetic mechanism and establish a metallogenic model. Fluid inclusion microthermometry and Laser Raman spectroscopic analysis results demonstrates that the aqueous ore-forming fluids evolved from low-medium salinity, medium–high temperature to low salinity, low-medium temperature fluids. Laser Raman spectroscopic analysis shows that CH4 is ubiquitous in fluid inclusions of all ore stages. Early ore fluids have δ18OH2O (v–SMOW) values from + 5.5 to + 6.2‰ and δD values of approximately − 67‰, concordant with a magmatic origin. However, the late ore fluids shifted toward lower δ18OH2O (v–SMOW) (as low as 0.3‰) and δD values (~ − 136‰), suggesting mixing between external fluids derived from the wall rocks and a contribution from meteoric water. Ti-in-quartz thermometry indicates a magmatic crystallization temperature of around 700 °C at a pressure of 1.5 kbar for the magmatic ore stage. Cathodoluminescence (CL) imaging and trace element analysis of quartz from a hydrothermal vug highlight at least three growth episodes that relate to different fluid pulses; each episode begins with CL-bright, Al-Li-rich quartz, and ends with CL-dark quartz with low Al and Li contents. Quartz from Episode 1 formed from early Sn-(Zn)-rich fluids which were likely derived from the quartz porphyry. Quartz from episodes 2 and 3 formed from Zn-(Sn)-Cu-rich fluid. The early magmatic fluid is characterized by low fS2. The SO2 produced by magma degassing reacted with heated water to form SO42−, causing the shift from low fS2 to high fS2. The SO42− generated was converted to S2– by mixing with CH4-rich, Fe and Zn-bearing external fluid which led to late-stage alteration and dissolution of micas in vein walls, thus promoting crystallization of pyrrhotite, Fe-rich sphalerite and chalcopyrite and inhibiting the precipitation of anhydrite. This study shows that ore formation encompassed multiple episodes involving steadily evolved fluids, and that the addition of external fluids plays an important role in the formation of the later Cu–Zn and Ag–Pb–Zn mineralization in the Weilasituo ore district.
Pan-caner analysis identifies PSMA7 as a targets for amplification at 20q13.33 in tumorigenesis
Authors: Sheng Guangying , Li Fuyu , Jin Wen , Wang Kankan 
Published: February 2024

AbstractThe chromosome 20 long arm (20q) is one of the genomic hotspots where copy number alterations frequently occur in multiple types of tumors. However, it remains elusive which genes are implicated in 20q-related tumorigenesis. Here, by querying TCGA and GEO databases, we observed frequent copy number amplification at 20q and the chromosome subband 20q13.33 was amplificated in multiple cancers. Among those genes at 20q13.33, PSMA7 was found with the strongest correlation with cancers. Further analysis revealed that PSMA7 amplification was the most frequent genetic alteration event conferring adverse prognosis in various cancers. Consistent with the strong positive correlation between PSMA7 amplification and gene expression, elevated PSMA7 expression was observed in 20 of 33 types of cancers with a close link to adverse outcomes in certain tumors. In addition, PSMA7 was essential for the growth of almost 1095 cancer lines. Mechanistically, aberrant PSMA7 most probably influenced the proteasome and protease-related pathways to promote tumorigenesis and might be antagonized by several compounds, e.g., Docetaxel in relevant cancers. The current in-depth pan-cancer analysis refines our understanding of the crucial oncogenic role of copy number amplifications at PSMA7 loci at the novel chromosome amplicon 20q13.33 across different tumors.
Visual search patterns during exploration of naturalistic scenes are driven by saliency cues in individuals with cerebral visual impairment
Authors: Walter Kerri , Manley Claire E. , Bex Peter J. , Merabet Lotfi B. 
Published: February 2024

AbstractWe investigated the relative influence of image salience and image semantics during the visual search of naturalistic scenes, comparing performance in individuals with cerebral visual impairment (CVI) and controls with neurotypical development. Participants searched for a prompted target presented as either an image or text cue. Success rate and reaction time were collected, and gaze behavior was recorded with an eye tracker. A receiver operating characteristic (ROC) analysis compared the distribution of individual gaze landings based on predictions of image salience (using Graph-Based Visual Saliency) and image semantics (using Global Vectors for Word Representations combined with Linguistic Analysis of Semantic Salience) models. CVI participants were less likely and were slower in finding the target. Their visual search behavior was also associated with a larger visual search area and greater number of fixations. ROC scores were also lower in CVI compared to controls for both model predictions. Furthermore, search strategies in the CVI group were not affected by cue type, although search times and accuracy showed a significant correlation with verbal IQ scores for text-cued searches. These results suggest that visual search patterns in CVI are driven mainly by image salience and provide further characterization of higher-order processing deficits observed in this population.
Age-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
Authors: Wang Xinyuan , Luo Yaru , He Siyu , Lu Ying , Gong Yanqiu , Gao Li , Mao Shengqiang , Liu Xiaohui , Jiang Na , Pu Qianlun , Du Dan , Shu Yang , Hai Shan , Li Shuangqing , Chen Hai-Ning , Zhao Yi , Xie Dan , Qi Shiqian , Lei Peng , Hu Hongbo , Xu Heng , Zhou Zong-Guang , Dong Biao , Zhang Huiyuan , Zhang Yan , Dai Lunzhi 
Published: February 2024

AbstractThe incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, sex and proximal–distal variations, we used a multi-omics approach in non-human primates (Macaca fascicularis) to shed light on the heterogeneity of intestinal aging and identify potential regulators of gut aging. We explored the roles of several regulators, including those from tryptophan metabolism, in intestinal function and lifespan inCaenorhabditis elegans. Suggesting conservation of region specificity, tryptophan metabolism via the kynurenine and serotonin (5-HT) pathways varied between the proximal and distal colon, and, using a mouse colitis model, we observed that distal colitis was more sensitive to 5-HT treatment. Additionally, using proteomics analysis of human CRC samples, we identified links between gut aging and CRC, with high HPX levels predicting poor prognosis in older patients with CRC. Together, this work provides potential targets for preventing gut aging and associated diseases.
Chancen und Herausforderungen der Ethikbegutachtung qualitativer
Versorgungsforschung – eine Befragung qualitativ
Forschender
Authors: Kremeike Kerstin , Jünger Saskia , Preiser Christine , Ullrich Charlotte , Xyländer Margret 
Published: February 2024

ZusammenfassungEthikkommissionen überprüfen die Einhaltung ethischer Prinzipien
bei medizinischen Forschungsvorhaben. Sie sind in ihrem Verfahren an klinischen
Studien ausgerichtet, begutachten aber z. B. auch qualitative Forschung.
In einer teilstrukturierten Online-Befragung wurden Erfahrungen qualitativ
Forschender mit der Begutachtung durch Ethikkommissionen erhoben und qualitativ
inhaltsanalytisch ausgewertet. Im Juli 2019 nahmen 73 Forschende an der
Befragung teil. Aus ihren Aussagen ließen sich fünf Kernthemen
bezüglich der Ethikbegutachtung qualitativer Forschung ableiten: 1)
Relevanz qualitativer Forschungsexpertise; 2) Kooperation zwischen Forschenden
und Ethikkommissionen; 3) Transparenz von Begutachtungskriterien; 4) Umgang mit
formalen Begutachtungsvorgaben; 5) Bewertung der Bedeutung der Begutachtung
für qualitative Forschung. Die Ergebnisse machen das Potential der
Ethikbegutachtung für die Reflexion ethischer Fragen in der qualitativen
Forschung deutlich. Grundlegend dafür wurden die Passung mit den
Merkmalen und Qualitätskriterien qualitativer Forschung sowie das
Vorhandensein qualitativer Forschungsexpertise in Ethikkommissionen genannt.
Zudem wurde die Transparenz des Prozesses der Ethikbegutachtung als
maßgeblich erachtet sowie eine Offenheit für unterschiedliche
Fachkulturen und eine konstruktive Kommunikationskultur.
Low Birth Weight is Associated with More Severe Course of
Steroid-Sensitive Nephrotic Syndrome in Children, Multicentric
Study
Authors: Konopásek Patrik , Skálová Sylva , Sládková Eva , Pecková Monika , Flachsová Eva , Urbanová Ivana , Laubová Jana , Samešová Martina , Dvořák Pavel , Zieg Jakub 
Published: February 2024

Abstract
Background Several previous studies have reported a more severe course of
nephrotic syndrome in children with low birth weight.
Patients Cohort of 223 children with idiopathic nephrotic syndrome.
Methods We aimed to investigate the association between course of
nephrotic syndrome and low birth weight. Data from seven paediatric nephrology
centres were used.
Results Children with low birth weight had 3.84 times higher odds for a
more severe course of steroid-sensitive nephrotic syndrome (95% CI
1.20–17.22, P=0.041), and those with low birth weight and
remission after 7 days had much higher odds for a more severe course of disease
(OR 8.7). Low birth weight children had a longer time to remission (median 12
vs. 10 days, P=0.03). They had a higher need for steroid-sparing agents
(OR for the same sex=3.26 [95% CI 1.17–11.62,
P=0.039]), and the odds were even higher in females with low birth
weight (OR 6.81). There was no evidence of an association either between low
birth weight and focal segmental glomerulosclerosis or between low birth weight
and steroid-resistant nephrotic syndrome.
Discussion We conducted the first multicentric study confirming the worse
outcomes of children with NS and LBW and we found additional risk factors.
Conclusions Low birth weight is associated with a more severe course of
steroid-sensitive nephrotic syndrome, while being female and achieving remission
after 7 days are additional risk factors.
Oral Anticoagulation and Mortality in Cases with Intracranial Bleeding: Analysis of Nationwide Prescription and Hospitalization Data
Authors: Kröger Knut , Heldt Fabian , Feyen Ludger , Feller Kathrin , Kowall Bernd , Stang Andreas 
Published: February 2024

Abstract
Objectives To demonstrate the safety of direct oral anticoagulants in relation to intracranial bleeding (ICB), we compared the number of patients taking anticoagulants in all cases of hospitalization and cases of hospitalization for ICB over time in Germany. We analyzed the intrahospital mortality of ICB cases in relation to long-term use of anticoagulants (LUAs).We performed a retrospective registry analysis of nationwide German hospitalizations including all hospital admissions and admission for ICB in patients aged ≥60 years in the period from 2006 to 2020 and separated for LUAs.
Results In 2006, the age-standardized rate of hospitalized male patients with LUAs was 7.3% and that of female patients was 5.6%. In 2020, the rates increased to 22.0 and 17.7% for male and female patients, respectively. Among patients hospitalized for ICB in 2006, 7.0 and 5.6% were male and female patients with LUAs, respectively. In 2020, the rate increased to 13.7% for males and 10.8% for females.In 2006, age-standardized mortality rates of male and female patients with ICB without LUAs were 24.1 and 23.9%, respectively. In 2020, the rate slightly decreased to 22.7% in males, but it remained almost unchanged in females at 23.8%. In the cases with LUA, the mortality rate decreased from 30.1 to 24.3% in males and from 28.4 to 24.2% in females in the same period.
Conclusion LUA seems to be safe because there is a slower increase of the rate of LUAs in ICB cases than in generally hospitalized cases in the period from 2006 to 2020. In addition, mortality in ICB cases with LUA tends to decrease compared to cases without LUA.
Rezidiv eines Desmoidtumors in einer Narbe an der Entnahmestelle
eines Latissimus-dorsi-Lappens
Authors: Abdu Hazem , Cedidi Can 
Published: February 2024

ZusammenfassungDer Desmoidtumor, auch bekannt als aggressiver fibröser Tumor oder
Desmoid-Fibromatose, ist ein seltener, gutartiger Tumor, der aus
Bindegewebszellen entsteht. Desmoidtumoren machen etwa 0,03+%
aller Neoplasien und weniger als 3+% aller Weichteiltumoren aus.
Die geschätzte Inzidenz in der Allgemeinbevölkerung
beträgt 2 bis 4 Fälle pro Million Einwohner pro Jahr [1]. Der
Desmoidtumor zeichnet sich durch sein aggressives Wachstum aus, metastasiert
jedoch in der Regel nicht. Er tritt häufig bei jungen Erwachsenen auf
und betrifft bevorzugt bestimmte Körperregionen wie den Bauch, die
Schulter, den Brustkorb oder die Extremitäten. Die genaue Ursache der
Erkrankung ist noch nicht vollständig geklärt, aber genetische
Veränderungen und hormonelle Faktoren könnten eine Rolle
spielen. Die Symptome eines Desmoidtumors hängen von seiner Lage und
Größe ab. Häufig treten Schmerzen, Schwellungen oder
Bewegungseinschränkungen auf. Die Diagnose erfolgt in der Regel durch
eine Gewebeprobe (Biopsie) und bildgebende Verfahren wie MRT oder CT [2]. Unser
vorliegender Fall stellt nach unserem Kenntnisstand den ersten dokumentierten
Fall eines Rezidivs eines Desmoidtumors in der Narbe an der Entnahmestelle des
Latissimus-dorsi- Lappens dar, welcher zuvor zur Rekonstruktion einer
Desmoidresektion am Unterschenkel verwendet wurde.
Algorithm for Rapid Exclusion of Clinically Relevant Plasma Levels of Direct Oral Anticoagulants in Patients Using the DOAC Dipstick: An Expert Consensus Paper
Authors: Harenberg Job , Gosselin Robert C. , Cuker Adam , Becattini Cecilia , Pabinger Ingrid , Poli Sven , Weitz Jeffrey , Ageno Walter , Bauersachs Rupert , Celap Ivana , Choi Philip , Douketis James , Douxfils Jonathan , Elalamy Ismail , Falanga Anna , Fareed Jawed , Favaloro Emmanuel J. , Gerotziafas Grigorios , Herkner Harald , Hetjens Svetlana , Heubner Lars , Klamroth Robert , Langer Forian , Lip Gregory Y. H. , Grory Brian Mac , Margetić Sandra , Merrelaar Anne , Pikta Marika , Renne Thomas , Schulman Sam , Schwameis Michael , Strbian Daniel , Tafur Alfonso , Vassart Julie , Violi Francesco , Walenga Jeanine , Weiss Christel 
Published: February 2024

Background With the widespread use of direct oral anticoagulants (DOACs), there is an urgent need for a rapid assay to exclude clinically relevant plasma levels. Accurate and rapid determination of DOAC levels would guide medical decision-making to (1) determine the potential contribution of the DOAC to spontaneous or trauma-induced hemorrhage; (2) identify appropriate candidates for reversal, or (3) optimize the timing of urgent surgery or intervention.
Methods and Results The DOAC Dipstick test uses a disposable strip to identify factor Xa- or thrombin inhibitors in a urine sample. Based on the results of a systematic literature search followed by an analysis of a simple pooling of five retrieved clinical studies, the test strip has a high sensitivity and an acceptably high negative predictive value when compared with levels measured with liquid chromatography tandem mass spectrometry or calibrated chromogenic assays to reliably exclude plasma DOAC concentrations ≥30 ng/mL.
Conclusion Based on these data, a simple algorithm is proposed to enhance medical decision-making in acute care indications useful primarily in hospitals not having readily available quantitative tests and 24/7. This algorithm not only determines DOAC exposure but also differentiates between factor Xa and thrombin inhibitors to better guide clinical management.
EUS-BD for calibration of benign stenosis of the bile duct in patients with altered anatomy or inaccessible papilla
Authors: Caillol Fabrice , Godat Sébastien , Solovyev Alexey , Harouchi Amina , Oumrani Sarra , Marx Mariola , Hoibian Solene , Dahel Yanis , Ratone Jean-Philippe , Giovannini Marc 
Published: February 2024

Abstract
Background and study aims In cases of inaccessible papilla, EUS-guided biliary drainage (EUS-BD) has been described as an alternative to calibrate benign biliary stenosis. However, few studies are available.
Patients and methods This tw-center, retrospective study was designed to evaluate technical success and clinical success at 1 year. All patients who underswent EUS-BD without the rendezvous technique used for calibration of benign biliary stenosis were included from 2016 to 2022. Patients underwent EUS-hepaticogastrostomy (EUS-HGS) during the first session. Then, HGS was used to access the bile duct, allowing calibration of the stenosis: Dilation of the biliary stenosis and placement of double pigtail stents through the stenosis for 1 year.
Results Thirty-six patients were included. Technical success was 89% (32/36), with four failures to cross the stenosis but EUS-HGS was performed in 100% of the cases. Nine patients were excluded during calibration because of oncological relapse in six and complex stenosis in three. Three patients had not yet reached 1 year of follow-up. Twenty patients had a calibration for at least 1 year. Clinical success after stent placement was considered in all cases after 1 year of follow-up. Thirteen patients underwent stent removal and no relapse occurred after 435 days of follow-up (SD=568). Global morbidity was 41.7% (15/36) with only one serious complication (needing intensive care), including seven cases of cholangitis due to intrabiliary duct obstruction and five stent migrations. No deaths were reported.
Conclusions EUS-BD for calibration in case of benign biliary stenosis is an option. Dedicated materials are needed to decrease morbidity.
Clinical Manifestations of Wegener Granulomatosis in Iranian Ethnicities Using the K-Means Algorithm: A Descriptive Study
Authors: Khedmatkon Fahimeh , Alesaeidi Samira , Hajialiasgari Fatemeh , Shoshtarian Malak Jaleh 
Published: February 2024

Abstract
Introduction Wegener granulomatosis (WG) appears with clinical symptoms, including recurrent respiratory infection, renal manifestations, and nonspecific systemic symptoms.
Objective To study the clinical manifestations of WG in Iranian ethnicities, and data on 164 patients were recorded from 2013 to 2018.
Methods The data included demographics, symptoms, and the Birmingham Vasculitis Activity Score (BVAS). The symptoms involved the following sites: the nose, sinus, glottis, ears, lungs, kidneys, eyes, central nervous system, mucous membranes, skin, heart, stomach, intestine, as well as general symptoms. The clinical manifestations of nine ethnicities were analyzed.
Results In total, 48% of the patients were male and 51% were female, with a median age of 51 years. The BVAS was of 15.4, the sites most involved were the sinus (n = 155), nose (n = 126), lungs (n = 125), and ears (n = 107). Gastrointestinal (n = 14) and cardiac (n = 7) involvement were less common. Among the patients, 48.17% were Persian, 13.41% were Azari, 11.17% were Gilaki, 11.17% were Kurd, and 10.9% were Lor.
Conclusion Our findings indicated that the sinus, nose, lungs, and ears were the sites most involved, and gastrointestinal and cardiac involvement were less common. In the present study, involvement of the upper and lower respiratory tract was higher than that reported in Western and Asian case series. Moreover, we report for the first time that, in all patients with ear involvement, the left ear was the first to be affected. The clinical manifestations among Iranian ethnicities were not different, and the Gilaki ethnicity had the highest BVAS, mostly because the weather was humid; therefore, in Iran, in areas with humidity, the rate of the disease was higher.
Effects of Maxillary Movements on Lips Following Orthognathic Surgery: A Retrospective Non-Randomized Clinical Trial
Authors: Tahmasbi Soodeh , Rahimipour Kasra , Namdari Mahshid , Tabrizi Reza , Seyedzadeghomi Fatemesadat 
Published: February 2024

Abstract
Introduction Lips play a fundamental role in facial attractiveness and in decisions pertaining to orthognathic surgery.
Objective To assess the upper lip changes following Le Fort I osteotomy for maxillary advancement and/or impaction.
Methods In the present retrospective non-randomized clinical trial, we evaluated 3 groups of patients who underwent Le Fort I osteotomy of the maxilla. Group 1 (n = 35) underwent maxillary advancement, group 2 (n = 14), maxillary impaction, and group 3 (n = 11) was submitted to both maxillary advancement and impaction. The lip thickness of all patients was measured preoperatively, and the participants in each group were categorized into two subgroups: thin (< 12 mm) and thick (> 12 mm) lip. The primary (before orthognathic surgery) and final (after orthodontic bracket removal) lateral cephalograms of the patients were analyzed using the Dolphin software. Comparisons were made using the paired t-test and linear regression in the IBM SPSS Statistics for Windows software.
Results The length of the upper lip increased by 1 mm (p = 0.012) on average following maxillary advancement, and it decreased by 0.43 mm (p = 0.24) on average following maxillary impaction. In the maxillary advancement group, the change in angulation of the incisors predicted the incisal display (p = 0.03). In the maxillary impaction group, skeletal changes in the vertical dimension predicted changes in upper lip length (p = 0.033).
Conclusions Le Fort I osteotomy for maxillary advancement significantly increases the length of the upper lip. The assessment of lip thickness prior to surgery can help predict the postoperative results. Changing the angulation of the incisors can predict the incisal display. In maxillary impaction, skeletal changes in the vertical dimension can predict the changes in the length of the upper lip.