bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shape stability of a quadrature surface problem in infinite Riemannian manifolds
Authors: DJITE Ababacar Sadikhe , SECK Diaraf 
Published: January 2024

Abstract
In this paper, we give a simple control on how an optimal shape can be characterized. The framework of Riemannian manifold of infinite dimension is essential. And the covariant derivative plays a key role in the computation and in the analysis of qualitative properties from the shape hessian. The control depends only on the mean curvature of the domain which is a minimum or a critical point. In the two dimensional case, the Gauss Bonnet theorem gives a control in the setting of the algorithm for the minimum.
Mathematical classification subject: 49Q10, 53B20
Multimodal imaging and genetic screening in Mexican patients with Gyrate Atrophy. Identification of novel OAT pathogenic variants.
Authors: Díazceballos-García Ana Lía , Matsui Rodrigo , Miranda María Graciela Chairez , Padrón Jaime Francisco Rosales , Graue-Wiechers Federico , Zenteno Juan Carlos 
Published: January 2024

Abstract

Purpose
Description of retinal phenotype by structural and functional testing, ornithine plasma levels and mutational data of OAT gene in patients with Gyrate Atrophy (GA).
Methods
Ophthalmologic examination, fundus photography (CFP), autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), Goldmann perimetry (GP), full-field electroretinogram (ffERG) and chromatic perimetry (CP) testing were performed. Ornithine plasma levels were measured. Sanger sequencing mutational analysis of the coding exons and exon-intron junctions of the OAT gene were analyzed.
Results
Twelve eyes of seven Mexican patients with GA were included. CFF showed peripheric patches of chorioretinal atrophy; FAF revealed peripheric oval areas of hypoautofluorescence; SD-OCT exhibited outer retinal tubulations in 58%, cystoid macular edema in 50%, epiretinal membrane in 42%, foveoschisis and staphyloma in 17%, and hyperreflective deposits in 100% of the eyes; GP showed constricted visual fields in 100% of the eyes; ffERG revealed preserved photopic response in 17% and preserved scotopic response in 17% of the eyes; CP exposed a deficit in generalized response of rods and cones in 100% of the eyes. Mean ornithine plasma levels were 509.5 µmol/L. One patient with genetic confirmation of GA had normal ornithine plasma levels (48 µmol/L). Molecular findings in OAT gene detected two novel pathogenic variants: c.796 C > T (p.Gln266*) and c.721_722dupCC (p.Asp242ArgfsTer6).
Conclusion
This study provides new information regarding functional and structural diagnosis in patients with GA, expands the understanding of retinal phenotype in patients with GA, reports two novel mutations and presents the first case of GA confirmed by genetic testing with normal ornithine levels.
Antitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
Authors: Han Jung-Min , Oh Kyu-Young , Choi Su-Jung , Lee Won-Woo , Jin Bo-Hwan , Kim Ji-Hoon , Yu Hyun-Ju , Kim Ryan Jin Young , Yoon Hye-Jung , Lee Jae-Il , Hong Seong-Doo , Cho Sung-Dae 
Published: January 2024

Abstract

Purpose: This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in oral cancer, focusing on the clinical relevance of EGFR and myeloid cell leukemia-1 (Mcl-1) in head and neck cancers (HNCs). It aims to explore the molecular mechanism of afatinib, a TKI, in treating human oral cancer.
Methods: We conducted an in silicoanalysis using databases like The Cancer Genome Atlas, Gene Expression Omnibus, and Clinical Proteomic Tumor Analysis Consortium, along with immunohistochemistry staining, to study EGFR and Mcl-1 expression in HNCs. For investigating afatinib's anticancer properties, we performed various in vitro and in vivo analyses, including trypan blue exclusion assay, Western blotting, 4′-6-diamidino-2-phenylindole staining, flow cytometry, quantitative real-time PCR, Mitochondrial membrane potential assay, overexpression vector construction, transient transfection, and a tumor xenograft model.
Results: Higher expression levels of EGFR and Mcl-1 were observed in HNC patient tissues compared to normal tissues, with their co-expression significantly linked to poor prognosis. There was a strong correlation between EGFR and Mcl-1 expressions in oral cancer patients. Afatinib treatment induced apoptosis and suppressed Mcl-1 in oral cancer cell lines without the EGFR T790M mutation. The mechanism of afatinib-induced apoptosis involved the EGFR/mTOR/Mcl-1 axis, as shown by the effects of mTOR activator MHY1485 and inhibitor rapamycin. Afatinib also increased Bim expression, decreased mitochondrial membrane permeabilization, and reduced cytochrome c release. It significantly lowered tumor volume without affecting body, liver, and kidney weights.
Conclusion: Afatinib, targeting the EGFR/mTOR/Mcl-1 axis, shows promise as a therapeutic strategy for oral cancer, especially in patients with high EGFR and Mcl-1 expressions.
UV-curable polyurethane-based, halogen-free, CaB4O7 nanoparticles decorated, flexible flame-retardant films
Authors: Beyler-Çiğil Aslı , Aytekin Yusuf Samet , Ceren Özde , Yılmaz Ayşen , Esenturk Okan 
Published: January 2024

Abstract
In this study, combinations of phosphorous silicone methacrylate monomer (PSiMA) and CaB4O7 nanoparticles (CBO NPs) were prepared for formation of halogen-free, flame-retardant, UV-curable polyurethane acrylate (PUA) films. The addition of either PSiMA or CBO NPs to PUA increased the flame-retardancy as expected, but the PSiMA-only addition, unfortunately, had adverse effects on the physical properties. However, the combined addition of PSiMA and CBO NPs not only resulted in the best performance on flame retardancy but also recovered the polymer’s thermal and physical properties. With additives high initial decomposition temperatures were observed in the range of 175–216°C. Among the combinations, PLU-60PSi-10NP (60 phr PSiMA + 10 phr CBO NPs) resulted in the best LOI performance of 27, which is 40% more than the PLU film (PUA-based film). In addition, the film had a remarkable char formation ability of 14.5% compared to PLU. The observed high LOI values could not be explained by the high percentages of P, Si, B, and N in the films, but the synergy among the additives was also considered. In this study, we have investigated the use of a promising technique, THz spectroscopy, on the characterization of these films as well. Very interestingly, the results showed a nice correlation between the dielectric responses measured by THz spectroscopy and the mechanical properties of the films. Observed great performances along with the simple preparation methods of these newly developed halogen-free, flame-retardant, PUA-based films are expected to significantly increase their potential use in many practical applications such as automobile, leather, printing, and coatings.
Improved Path Planning Algorithm Based on EB-RRT and APF
Authors: Jing Wenhao , Gao Kai , Li Shanze 
Published: January 2024

Abstract
In practical operating environments, it is extremely important for mobile robots to reach the target area quickly and safely. Therefore, a new path planning algorithm, APF-EB-RRT, based on the EB-RRT algorithm was proposed in this article. The artificial potential field algorithm was introduced into the APF-EB-RRT algorithm. By adding potential field constraints that simulate the interaction between objects to the dynamic reprogramming structure, the EB-RRT algorithm can avoid the problems of high randomness and poor directionality caused by the EB algorithm. Meanwhile, the APF-EB-RRT algorithm can effectively avoid collisions between robots and obstacles, and guide robots to the target area. The effectiveness of the APF-EB-RRT algorithm was demonstrated by numerical simulation results. The APF-EB-RRT algorithm exhibited better performance in various environments than the other four algorithms. In a real dynamic environment, this algorithm can provide better path planning for mobile robots, and has good application prospects in the field of path planning.
Plate Fixation of Inferior Ramus in Pubis-Ischium Ramus Improves Mechanical Stability in Tile B Pelvic Injures: A Cadaveric Biomechanical Analysis and Early Clinical Experience
Authors: Pan Zhongjie , Hu Feng , Li Yuquan , Li Muwen , Chen Min , Huang Wengui , Qin Lili , Li Yuanjun , Liu Wei 
Published: January 2024

Abstract
Background
Management of inferior ramus of the pubis-ischium ramus remains controversial, and related research is sparse. The main intention of this study is to describe the biomechanical and clinical outcomes of pubis-ischium ramus fractures in Tile B pelvic injuries and to identify the feasibility and necessity of fixation of the inferior ramus of the pubis-ischium ramus.
Methods
This study comprised two parts: a biomechanical test and a retrospective clinical study. For the biomechanical tests, Tile B-type pelvic injuries were modeled in six cadaver specimens by performing pubis-ischium osteotomies and disruption of the anterior and interosseous sacroiliac ligaments. The superior and/or inferior rami of the pubis-ischium ramus were repaired with reconstruction plates and separated into three groups (A, B, and C). Specimens were placed in the standing position and were loaded axially with two-leg support for three cycles at 500 N. The displacements of sacroiliac joints at osteotomy were measured with Vernier calipers and compared using statistical software. To investigate the clinical outcomes of this technique, 26 patients were retrospectively analyzed and divided into a superior ramus fixation group (Group D) and a combined superior and inferior ramus of the pubis-ischium ramus fixation group (Group E). The main outcome measures were time of operation, blood loss, postoperative radiographic reduction grading, and functional outcomes.
Results
In the vertical loading test, Group E showed better pelvic ring stability than Group D (P < 0.05). However, the shift of the sacroiliac joints was almost identical among the three groups. In our clinical case series, all fractures in Group E achieved bony union. Group E demonstrated earlier weight-bearing functional exercise (2.54 ± 1.45 vs. 4.77 ± 2.09; P = 0.004), earlier bony union (13.23 ± 2.89 vs. 16.55 ± 3.11; P = 0.013), and better functional outcomes (89.77 ± 7.27 vs. 82.38 ± 8.81; P = 0.028) than Group D. The incidence of sexual dysfunction was significantly lower in Group E than that in Group D (2/13 vs. 7/13; P = 0.039). Bone nonunion occurred in two patients in Group D, and two patients in Group E had heterotopic ossification. None of the patients exhibited wound complications, infections, implant failures, or bone–implant interface failures.
Conclusion
Fixation of the inferior ramus of a pubis-ischium ramus fracture based on conventional fixation of the anterior pelvic ring is mechanically superior in cadaveric Tile B pelvic injury and shows rapid recovery, good functional outcomes, and low incidence of complications.
Object-oriented concept approach on rough granular lattice with discernibility object granular
Authors: Srir B. , Sathish Shakeela , Kartthik Krishnasamy , Mallik Saurav , Li Aimin , Shah Mohd Asif 
Published: January 2024

Abstract

The discernibility matrix acts as an efficient tool to determine decision-making problems. The discernibility matrix enhances both the logical and theoretical knowledge of an information system. Also, it evaluated the boolean function for enhancing its relevant properties. In this paper, a granular lattice has been discussed to define a consistent set, based on object-oriented concepts. An ordered pair of attributes and objects was constructed to determine the granular lattice using indiscernibility relation. We have introduced two sets, namely the maximum and minimum sets to analyze the indiscernibility object. The indiscernibility object investigates the upper approximation space and extended its effectiveness towards maximum and minimum sets. Furthermore, the properties of the maximum set and minimum set are classified using the granularity concept. An equivalency condition is framed by the maximum set and its results are examined with the help of some theorems and lemma.
Papillary thyroid carcinoma synchronous with high-grade non-Hodgkin's lymphoma: A case report
Authors: Hafi Zakaria El , Hjaouj khalil , Bencheikh Razika , Benbouzid Mohamed Anas , Oujilal Abdelilah , Essakalli Leila 
Published: January 2024

Abstract
Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma, accounting for up to 90% of all thyroid malignancies. The association with an hematological malignancy is very rare, representing an incidence of only 7%.
We present a case of synchronous papillary thyroid cancer and non-Hodgkin's lymphoma (NHL) and discuss possible dilemmas in diagnosis and treatment.
A 60-year-old woman with no medical or radiation history presented with a hard, immobile left supraclavicular swelling. Cervical ultrasound showed the presence of a suspicious-looking supraclavicular adenopathy with two right lobar thyroid nodules classified EU-TIRADS 4. We performed a total thyroidectomy with right central latero-cervical functional left curage and excision of the left supraclavicular adenopathy. Pathological examination revealed papillary thyroid carcinoma synchronous with high-grade non-Hodgkin's lymphoma.
After a multidisciplinary consultation, the patient received six courses of chemotherapy before undergoing irratherapy. This article highlights the importance of a multidisciplinary approach in the absence of consensus, given the rarity of this case.
Test-Retest reliability of prepulse inhibition (PPI) and PPI correlation with working memory
Authors: Freudenberg Florian , Althen Heike , Falk Kim , Bittner Robert A. , Reif Andreas , Plichta Michael M. 
Published: January 2024

Abstract
Objective: Sensorimotor gating is experimentally operationalized by the prepulse inhibition (PPI) of the startle response (SR). Previous studies suggest high test-retest reliability of PPI and potential correlation with working memory (WM). Here we aimed to validate and extend the test-retest reliability of PPI in healthy humans and its correlation with working memory (WM) performance.
Methods: We applied an acoustic startle PPI paradigm with four different prepulse intensities (64, 68, 72, and 76 dB) and two different WM tasks (n-back, change detection task [CDT]) in a group of 26 healthy adults (final sample size n=23). To assess test-retest reliability, we performed all tests on two separate days 28 days apart.
Results: We were able to confirm high test-retest-reliability of the PPI with a mean intraclass correlation (ICC) of >0.80 and significant positive correlation of PPI with n-back but not with CDT performance. Detailed analysis showed that PPI across all prepulse intensities significantly correlated with both the 2-back and 0-back conditions, suggesting regulation by cross-conditional processes (e.g. attention). However, when removing the 0-back component from the 2-back data, we found a specific and significant correlation with WM for the 76 dB PPI condition.
Conclusion: With the present study we were able to confirm the high test-retest reliability of the PPI in humans and could validate and expand on its correlation with WM performance.
Analisis Penerapan Konsep Desain Arsitektur Tropis pada Hotel Alila Seminyak, Bali
Authors: Nurjani Ni Putu Suda 
Published: January 2024

Title: Implementation’s Analysis of Tropical Architectural Design Concepts at Alila Seminyak Hotel, Bali

Tropical architecture is born from efforts to adjust to the climate in the tropics. Tropical architectural design always shows the form of adaptation of buildings to the environment. Traditional Balinese houses that function as community residential units are one of the tropical architectural typologies with the main advantage of thermal comfort, especially on air circulation flow that flows well throughout the building. However, when reviewing further commercial buildings in Bali, especially star hotels, the implementation of tropical architecture is a theme that requires deep design thinking. Adjustment to Balinese regional regulations on buildings is very binding; limited sites and demands for comfort and suitability of building functions are challenging for architects to design an accommodation building with a tropical architectural concept. Alila Seminyak Hotel is one of the five-star hotels outside the ITDC Nusa Dua area, which tries to form a tropical architectural identity as the main attraction. This qualitative descriptive research takes the case study of Alila Seminyak Hotel. Assessment analysis was carried out on the physical form of the hotel building, which was then appropriated and compared with tropical architectural theory. The results of this study show that the implementation of tropical architecture in the Alila Seminyak hotel building can be classified into several main elements, namely, first is the form of laying the building period on-site, second is the orientation pattern of the building, and third is The physical design of the building emphasizes, that this building have three main concept designs, it is namely insulation, shading, and cross ventilation.
Hydroclimatic projection: statistical learning and downscaling model for rainfall and runoff forecasting
Authors: Kodihal Shweta , Akhtar M. P. , Maurya Satya Prakash 
Published: January 2024

Abstract

The study is carried out to investigate the surface runoff depth with changing precipitation due to climate change in the study area where sandy loam and loamy soil are dominant. In this study, future rainfall is projected by a statistical downscaling model (SDSM) using a set of predictors derived from a Coupled Model Intercomparison Project Phase 6 (CMIP6) global climate model (GCM) [the Norwegian Earth System Model (NorESM)] with updated scenarios SSP 4.5 and SSP 8.5. Daily rainfall values for the observed period (1981 to 2014) are validated using statistical learning and evaluated with matrices, namely, root mean square error (RMSE), coefficient of correlation, and Nash–Sutcliffe efficiency (NSE), which are found to be valid for further predictions. Rainfall projections show a decrease in rainfall trend of 50% from 2030 to 2040 for scenario SSP 4.5 and an increase of 7% from 2040 to 2050. Predicted rainfall for scenario SSP 8.5 shows a similar trend of decreasing rainfall of 24% for the period 2030–2040 and an increase of 19% in the period 2040–2050. Furthermore, these rainfall values are spatially modelled in a geographic information system (GIS) and rainfall maps are obtained. The obtained rainfall map, land-use map, and soil map are overlaid to compute curve numbers and runoff depths. A similar trend of decrease in runoff is observed for the period 2030–2050. The overall trend of climate change shows a water-stressed scenario.
Productividad y crecimiento de largo plazo
Authors: Méndez Briones Luis 
Published: January 2024

Según estudios del Banco Central de Chile, la productividad total de factores, en los últimos treinta años, viene mostrando un paulatino decrecimiento. 3,5% en 1991-1995; 0,2% en 1996-2000; 1,0% en 2001-2005; 0,6% en 2006-2010; -0,1% en 2011-2015 y -0,1% en 2016-2020 (B. Central de Chile; Evolución de la productividad, 2021).
Sus factores determinantes son la calidad del trabajo, la cantidad y calidad del capital físico y la eficiencia.
Tourist Loyalty Model Visiting Culinary Tourism Destinations
Authors: Setiawan Heri , Hamid Abd , Bustan Jusmawi , Ummasyroh  
Published: January 2024

Most of the culinary tourism destinations in Palembang City have not opened to serve visitors since the Covid-19 pandemic occurred in early 2020. This has an impact on the intensity of tourist visits to culinary tourism destinations in Palembang City which has decreased. Then, decrease in the culinary experience, cleanliness, comfort of culinary tourism destinations, and destination management services. The purpose of the study was to analyze the connection between the experience of tourists, value perception, destination quality, satisfaction, and tourist loyalty. The type of research is quantitative research with a causality approach. The population of the study is local travelers who have come to culinary tourism destinations in Palembang at least 2 times. Purposive sampling was used to determine the respondents with a sample of 216. Structural equations are used as a method of analysis. The outcomes of the study explain that there is no linear association betwixt tourist experience and satisfaction of tourists. Value of perception, destination quality, and satisfaction of tourists are linearly related. Tourist experience, destination quality, and tourist loyalty are not linearly related. Value perception and tourist loyalty are linearly related. Then, tourist satisfaction and tourist loyalty are linearly related. This research can be a reference for tourist destination managers to maintain the loyalty of tourists visiting culinary tourism destinations, and become a reference for the next research in destination marketing.
The potential of rambutan honey toothpaste in reducing the dental plaque index: a quasi Experimental study
Authors: Yuslianti Euis Reni , Ningrum Anindya Sekar Ayu , Endrowahyudi Hartanto 
Published: January 2024

ABSTRACTIntroduction: The accumulation of dental plaque is a common cause of dental and oral health problems such as caries and periodontitis, therefore it is necessary to control plaque. Brushing is the most effective way to control plaque. Currently, there are various toothpastes used by the people, one of which is herbal toothpaste. One of the herbal toothpastes that has an antibacterial potential is rambutan honey toothpaste. The purpose of this study was to analyze the effectiveness of rambutan honey toothpaste in reducing the dental plaque index. Methods: this research was Quasi Experimental design research with a pre-test post-test control group design. The twenty samples were divided into three treatment groups, namely the group that brushed teeth with base toothpaste, rambutan honey toothpaste, and aquadest. All samples were asked to brush their teeth using base toothpaste, rambutan honey toothpaste, and aquadest twice, after using toothpaste for one day, the plaque index was measured by the Silness and Loe method. Data were analyzed using Kruskal-Wallis and post hoc Mann-Whitney tests (p<0.05). Results: There was a significant difference between the plaque index score before and after using rambutan honey toothpaste with a p value=0.005 (p≤0.05). The results also showed the effect of brushing teeth with base toothpaste, rambutan honey toothpaste, and aquadest on plaque index with a value of p=0.005 (p≤0.05). The results showed that there was no significant difference in dental plaque index between base toothpaste and rambutan honey toothpaste with a p value=0.583. Conclusion: Rambutan honey toothpaste has a potential in reducing the dental plaque index.Keywords: plaque index, rambutan honey, toothpaste