bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape of ice and fire – uniquely well-preserved Scots pine trunks reveal forest fires near the retreating Weichselian ice margin
Authors: Klaminder Jonatan , Fassl Magdalena , Baudet Marlène , Östlund Lars , Linderholm Johan , Zale Rolf 
Published: December 2023

AbstractEnvironmental conditions for trees that established in central Fennoscandia shortly after the final retreat of the Weichselian ice sheet remain poorly understood. In this study we examine tree rings of five well-preserved Pinus sylvestris (Scots pines) that grew in the area in front of the retreating ice sheet in northern Sweden. They became buried in flood sediments deposited by a glacial outburst flood (jökulhlaup) about 9.5–9.9 kyr cal bp and the aim of our study was to search for information regarding damage from fires and bioclimatic conditions in their ancient tree ring records. Our analysis, providing a glimpse into the local early Holocene environment in north-central Sweden, suggests that: 1, there were repeated fires (four fire events detected) during the early Holocene; and 2, bioclimatic conditions when the ancient pines were growing resembled those of modern sub-alpine pine woods. The latter is indicated by their patterns of tree ring growth (growth rate and variation), which were statistically similar to those of pines growing in sub-alpine woods with an open canopy, but different from pines in protected and managed boreal forests. Lower δ13C for the ancient latewood in comparison to pine wood from trees growing near the Scandinavian mountains before the 1850s were probably caused both by stomata fractionation due to lower atmospheric CO2 during the early Holocene and by the moist local environment created by the nearby ancient Ancylus lake, which preceded the Baltic Sea. Periods with cloudy and cold summers were also indicated by the occurrence of ‘false rings’. Finds of charred fragments of Calluna vulgaris (heather, ling), an understory shrub that can burn even with a relatively high moisture content, suggest that heath vegetation was crucial to make fire a reoccurring ecological factor in the area during the early Holocene.
Epidemiologische Daten und medizinische Versorgungssituation von Patienten mit chronischen Entzündungserkrankungen in Deutschland
Authors: Riemekasten Gabriela , Schmelz Renate , Schäkel Knut , Thaci Diamant , Schreiber Stefan , Röcken Marit , Bartz Holger , Ploner Tina , Liao Ximing , Weber Valeria , Manz Karina C. , Burkhardt Harald , Leipe Jan 
Published: December 2023

Zusammenfassung
Hintergrund
Chronisch entzündliche Erkrankungen („immune-mediated inflammatory diseases“ [IMID]) können aufgrund klinischer Gemeinsamkeiten überlappen oder gleichzeitig auftreten. Die daraus resultierende Inanspruchnahme von Versorgungsstrukturen wurde bisher nicht fachübergreifend untersucht, ist aber für eine optimierte Behandlung der Patienten mit IMID potenziell von Bedeutung.

Ziel der Arbeit
Analyse epidemiologischer Daten einschließlich Inanspruchnahme von Versorgungsleistungen bei Patienten mit ausgewählten IMID: Psoriasis, Psoriasisarthritis (PsA), rheumatoide Arthritis (RA), Spondylitis ankylosans, Colitis ulcerosa, Morbus Crohn und Kollagenosen.

Material und Methoden
In einer retrospektiven Querschnittanalyse, basierend auf Abrechnungsdaten der gesetzlichen Krankenversicherung (GKV) mit einer Stichprobe von ca. 4 Mio. Versicherten, wurden die Prävalenz o. g. IMID und die Häufigkeit von IMID-Kombinationen anhand dokumentierter Diagnosen (ICD-10 GM) analysiert. Die Häufigkeit von Hospitalisierungen und Inanspruchnahmen ambulanter Arztkontakte wurde in vordefinierten Fachdisziplinen (Allgemeinmedizin, Dermatologie, Gastroenterologie, Rheumatologie) erfasst und mit einer alters- und geschlechtsadjustierten Referenzpopulation verglichen.

Ergebnisse
Insgesamt wiesen 188.440 Patienten mindestens eine der analysierten IMID-Diagnosen auf (4,7 %), mit einem Altersgipfel von 61 bis 70Jahren. Die höchste Prävalenz wurde für die Psoriasis (1,85 %), gefolgt von der rheumatoiden Arthritis (1,38 %) gesehen. Kombinationen mit mindestens einer weiteren IMID kamen insgesamt relativ häufig vor (29 %), wobei dies bei Patienten mit Psoriasisarthritis am häufigsten zu verzeichnen war (82,9 %, wobei hiervon 68,2 % Psoriasis), gefolgt von Spondylitis ankylosans (27,5 %) und Morbus Crohn (21,6 %). Patienten mit IMID wurden im Vergleich zur Referenzpopulation häufiger hospitalisiert und wiesen häufigere Inanspruchnahmen der betrachteten ambulanten Fachdisziplinen auf.

Diskussion
Die Studienergebnisse beschreiben, dass IMIDs gehäuft koexistieren und die Patienten Versorgungsstrukturen verschiedener Fachgebiete vergleichsweise mehr in Anspruch nehmen. Ein multidisziplinärer Ansatz könnte die Effizienz der Versorgung steigern, eine Evaluierung steht aus.
What’s important for recovery after a total knee replacement? A systematic review of mixed methods studies
Authors: Khatri Chetan , Ahmed Imran , Dhaif Fatema , Rodrigues Jeremy , Underwood Martin , Davis Edward T. , Mitchell Paul , Metcalfe Andrew 
Published: December 2023

Abstract
Background
Understanding how patients perceive and prioritise various aspects of recovery following total knee replacement, including pain, function and return to activity, will help clinicians in pre-operative consultations by ensuring they effectively address patient concerns and managing their expectations.

Aims
The aim of this study is to identify aspects of recovery that are important to people after a total knee replacement.

Methods
Studies were identified from Medline, Embase, PsycInfo, Cochrane Library and Web of Science. This mixed methods review included all original study types (quantitative, qualitative, discrete choice experiments and mixed methods design). Reviews and non-peer-reviewed publications were excluded. Studies with participants (age ≥ 18 years) who had a primary TKR for osteoarthritis were included. Studies of people with unicompartmental knee, patella-femoral or revision knee replacement were excluded. Recovery attributes were extracted from individual papers and grouped into recovery themes.

Results
A total of 23 studies with 8404 participants and 18 recovery themes were developed. The most frequently identified overarching theme was pain, followed by activities of daily living, mobility (walking), recreational activities, specific functional movements of the knee, use of walking aids, sexual activity and range of motion of the knee. Medical complications were an infrequently reported theme, however, was deemed to be high importance.

Conclusions
Reducing pain, returning of activities and daily living and mobility are the three most frequently reported recovery domains for people after TKR. Clinicians should be aware of recovery themes, to ensure they are explored sufficiently when consenting for a TKR. Future research should aim to determine the relative importance of these attributes compared to each other.
Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021253699
Evidence for converging pathophysiology in complex regional pain-syndrome and primary headache disorders: results from a case–control study
Authors: Wiemann Matthias , Zimowski Nikolas , Blendow Sarah-Luis , Enax-Krumova Elena , Naegel Steffen , Fleischmann Robert , Strauss Sebastian 
Published: December 2023

Abstract
Background
Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.

Methods
Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case–control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaints, headache entity, and clinical management.

Results
Patients with CRPS were significantly more likely to suffer from migraine (OR: 3.23, 95% CI 1.82–5.85), TAC (OR: 8.07, 95% CI 1.33–154.79), or non-classified headaches (OR: 3.68, 95% CI 1.88–7.49) compared to the control group. Patients with MIG/TAC developed CRPS earlier in life (37.2 ± 11.1 vs 46.8 ± 13.5 years), had more often a central CRPS phenotype (60.6% vs. 37.0% overall) and were three times more likely to report allodynia compared to CRPS patients with other types of headaches. Additionally, these patients experienced higher pain levels and more severe CRPS, which intensified with an increasing number of headache days. Patients receiving monoclonal antibody treatment targeting the CGRP pathway for headaches reported positive effects on CRPS symptoms.

Conclusion
This study identified clinically relevant associations of MIG/TAC and CRPS not explained by chance. Further longitudinal investigations exploring potentially mutual pathomechanisms may improve the clinical management of both CRPS and primary headache disorders.

Trial registration
German Clinical Trials Register (DRKS00022961).
P-recovery versus current sewage sludge treatment policy in the Czech Republic and Japan
Authors: Hušek Matěj , Homma Ryosuke , Moško Jaroslav , Pohořelý Michael , Oshita Kazuyuki 
Published: December 2023

AbstractPhosphorus is an important element for agriculture and industry, but its deposits are not uniformly distributed. Countries that do not have primary sources are dependent on imports or regeneration from secondary materials. A widely available secondary source is sewage sludge. Used environmental standards govern sludge treatment, but its inclusion in the raw material policy is often missing. We focus on the Czech Republic (a European Union member) and Japan, countries without phosphorus deposits. Based on our analysis of sewage sludge flows, legislation, and technologies used, we aimed to evaluate approaches towards sustainable phosphorus policy. We figured out that in the Czech Republic, sludge application to soil continues due to legislation deregulation and thus, various pollutants enter the soil along with the sludge. In Japan, thermal treatment predominates, but ash is not processed, and phosphorus is irreversibly lost in landfills or construction. By not implementing a functional P-recovery policy, both countries lose more than 13 % replacement of phosphorus fertilisers from their sources.
Graphical Abstract
A semantics-enabled approach for personalised Data Lake exploration
Authors: Bianchini Devis , De Antonellis Valeria , Garda Massimiliano 
Published: December 2023

AbstractThe increasing availability of Big Data is changing the way data exploration for Business Intelligence is performed, due to the volume, velocity and uncontrolled variety of data on which exploration relies. In particular, data exploration is required in Data Lakes that have been proposed to host heterogeneous data sources, given their flexibility to cope with cumbersome properties of Big Data. However, as data grows, new methods and techniques are required for extracting value and knowledge from data stored within Data Lakes, aggregating data into indicators according to multiple analysis dimensions, to enable a large number of users with different roles and competencies to capitalise on available information. In this paper, we propose PERSEUS (PERSonalised Exploration by User Support), a computer-aided approach for data exploration on top of a Data Lake, structured over three phases: (1) the construction of a semantic metadata catalog on top of the Data Lake, leveraging tools and metrics to ease the annotation of the Data Lake metadata; (2) modelling of indicators and analysis dimensions, guided by an openly available Multi-Dimensional Ontology to enable conformance checking of indicators and let users explore Data Lake contents; (3) enrichment of the definition of indicators with personalisation aspects, based on users’ profiles and preferences, to make easier and more usable the exploration of data for a large number of users. Results of an experimental evaluation in the Smart City domain are presented with the aim of demonstrating the feasibility of the approach.
Survey and analysis on the use and disposal of plastic shopping bags before and after the introduction of charges
Authors: Nishijima Asako , Nakatani Jun 
Published: December 2023

AbstractJapan implemented mandatory charging for single-use plastic shopping bags in 2020. In this study, we verified the policy effect and its persistence by analyzing the changes in the number of plastic shopping bags taken and discarded by consumers before and after the charging came into effect. Online surveys were conducted in 2016, 2021, 2022, and 2023 for consumers residing in municipalities in Tokyo. The results showed that the number of plastic shopping bags taken decreased to approximately 30% after the charging was implemented, from 5.8 bags per person per week in 2016 to 1.7–1.9 in 2021–2023, and the number of bags discarded decreased from 6.2 to 3.0–3.4. The number of bags taken in 2021–2023 after the charging was implemented did not change significantly. Regarding the relationship with other waste policies, in municipalities that have introduced designated trash bags, the number of plastic shopping bags taken and discarded was fewer than in other municipalities even before the charging was introduced, by removing the option of reusing plastic bags as trash bags. This result indicates that, when introducing such policies, the relationship with existing waste policies must be analyzed to predict their effect.
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Authors: Lin Yanzhu , Gahn Johannes , Banerjee Kuheli , Dobreva Gergana , Singhal Mahak , Dubrac Alexandre , Ola Roxana 
Published: December 2023

AbstractArterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary bed. Either familial inherited or sporadically occurring, localized pericytes (PCs) drop is among the AVMs’ hallmarks. Whether impaired PC coverage triggers AVMs or it is a secondary event is unclear. Here we evaluated the role of the master regulator of PC recruitment, Platelet derived growth factor B (PDGFB) in AVM pathogenesis. Using tamoxifen-inducible deletion of Pdgfb in endothelial cells (ECs), we show that disruption of EC Pdgfb-mediated PC recruitment and maintenance leads to capillary enlargement and organotypic AVM-like structures. These vascular lesions contain non-proliferative hyperplastic, hypertrophic and miss-oriented capillary ECs with an altered capillary EC fate identity. Mechanistically, we propose that PDGFB maintains capillary EC size and caliber to limit hemodynamic changes, thus restricting expression of Krüppel like factor 4 and activation of Bone morphogenic protein, Transforming growth factor β and NOTCH signaling in ECs. Furthermore, our study emphasizes that inducing or activating PDGFB signaling may be a viable therapeutic approach for treating vascular malformations.
Results of archival appraisal: a study of a Finnish City
Authors: Henttonen Pekka , Packalén Saara 
Published: December 2023

AbstractThe study investigates which information is chosen for long-term retention in a municipality in Finland. The municipal Records Management Plan of the City of Helsinki was analyzed quantitatively to provide the research data. The results show that information pertaining to permanent or long-standing objects and phenomena, as well as those with long-lasting consequences (such as high-level decision-making, environmental factors, constructions, land use, and people), are more likely to have extended retention periods and may even be preserved permanently. According to archival literature, archival appraisal is a process influenced by theoretical considerations. However, the findings suggest that practical factors tend to guide the appraisal process more significantly. This raises the question of how appraisal decisions are made. The perceived value of information may depend on the level of detail provided about the functions and processes, as well as the knowledge possessed by the appraisers. However, the role that archival theory and other factors play cannot be understood without additional research.
Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice
Authors: Grube Meret , Dimmler Arno , Schmaus Anja , Saup Rafael , Wagner Tabea , Garvalov Boyan K. , Sleeman Jonathan P. , Thiele Wilko 
Published: December 2023

AbstractKetogenic diets (KDs) can improve the well-being and quality of life of breast cancer patients. However, data on the effects of KDs on mammary tumors are inconclusive, and the influence of KDs on metastasis in general remains to be investigated. We therefore assessed the impact of a KD on growth and metastasis of triple negative murine 4T1 mammary tumors, and on the progression of luminal breast tumors in an autochthonous MMTV-PyMT mouse model. We found that KD did not influence the metastasis of 4T1 and MMTV-PyMT mammary tumors, but impaired 4T1 tumor cell proliferation in vivo, and also temporarily reduced 4T1 primary tumor growth. Notably, the ketogenic ratio (the mass of dietary fat in relation to the mass of dietary carbohydrates and protein) that is needed to induce robust ketosis was twice as high in mice as compared to humans. Surprisingly, only female but not male mice responded to KD with a sustained increase in blood β-hydroxybutyrate levels. Together, our data show that ketosis does not foster primary tumor growth and metastasis, suggesting that KDs can be safely applied in the context of luminal breast cancer, and may even be advantageous for patients with triple negative tumors. Furthermore, our data indicate that when performing experiments with KDs in mice, the ketogenic ratio needed to induce ketosis must be verified, and the sex of the mice should also be taken into account.
Diversity of reproductive characters, seed set, and viability of Agave seeds used for pulque production and their wild relatives in Tlaxcala, Mexico
Authors: Trejo Laura , Soriano Diana , Romano-Grande Elvira , Sánchez-Carmona Bárbara , Dávila-Navarro Diego E. 
Published: December 2023

AbstractAgave is one of the most important genera of plants in Mexico in terms of biodiversity and cultural and economic impact; however, its reproductive traits and breeding systems are poorly known. In addition, clonal propagation of agave cultures and the interruption of sexual reproduction may lead to differences not only in reproductive traits but also in seed set and seed viability across species and between wild plants and Agave landraces. Hence this research evaluated the morphological variation of flowers, fruits, and seeds throughout the infructescence development of pulquero agave landraces (Agave americana, A. mapisaga, and A. salmiana) and their wild relatives (A. salmiana) using statistical analyses. Additionally, seed set and seed viability (tetrazolium test) were estimated for traditional (metepantle) and intensive (monoculture) cultivation systems. The analysis of flowers allowed differentiating between species (A. mapisaga and A. salmiana), while the analysis of fruits separated wild from cultivated plants. Wild agaves attained seed set values close to 0.5, and cultivated agaves, less than 0.2; the lowest seed set values (0.04) were observed under monoculture. Seed viability percentages depended on the taxon analyzed, with no clear differences between wild and cultivated taxa. There were positive correlations between branch length, fruit number, black (potentially viable) seed number, and the percentage of viable seeds. The highest percentage of viable seeds was recorded in the low and middle parts of the infructescence. Our results demonstrate that reproductive traits are suitable for recognizing morphological groups across species and between wild and landrace agaves. They also show that intensive and prolonged clonal propagation is associated with low seed set and seed viability values in Agave landraces.
The Locus of Agency in Extended Cognitive Systems
Authors: Tomczyk Barbara 
Published: December 2023

AbstractThe increasing popularity of artificial cognitive enhancements raises the issue of their impact on the agent’s personal autonomy, and issues pertaining to how the latter is to be secured. The extended mind thesis implies that mental states responsible for autonomous action can be partly constituted by the workings of cognitive artifacts themselves, and the question then arises of whether this commits one to embracing an extended agent thesis. My answer is negative. After briefly presenting the main accounts on the conditions for autonomous agency, and analyzing how the latter can be protected from threats posed by the use of cognitive artifacts, I argue that autonomous agency is essentially tied to conscious experience and intentionality, which in turn can only be attributed to the human part of any extended cognitive system. I present both theoretical (conceptual) and practical arguments against recognizing the entire extended system, composed of one human and an artifact, as an autonomous agent.
The Szymczak Functor and Shift Equivalence on the Category of Finite Sets and Finite Relations
Authors: Przybylski Mateusz , Mrozek Marian , Wiseman Jim 
Published: December 2023

AbstractThe construction of the Conley index for dynamical systems with discrete time requires an equivalence relation between morphisms induced on index pairs. It follows from the features of the Szymczak functor that shift equivalence, whose equivalence classes are the isomorphism classes in the Szymczak category, is the most general equivalence available. In the case of dynamics modeled from data, the morphisms induced on index pairs are relations. We present an algorithmizable classification of shift equivalence classes for the category of finite sets with arbitrary relations as morphisms. The research is the first step towards the construction of a Conley theory for relations.
How Does Religiosity Influence Gambling? A Cross-Cultural Study Between Portuguese and English Youth
Authors: Calado Filipa , Vernon Mike , Nuyens Filip , Alexandre Joana , Griffiths Mark D. 
Published: December 2023

AbstractResearch has shown that religion can play a protective role in diverse risky behaviors among young people. However, very little is known about the effect of religion in gambling, especially among young problem gamblers. A strong moral belief regarding gambling may prevent adolescents and young adults engaging in gambling and developing problems. Nevertheless, some evidence suggests that religion might have an influence on gambling cognitive distortions (i.e., some religious beliefs might influence the conceptions of chance and luck, which may contribute to an increase in gambling participation). The present study examined the different effects that religion can have on gambling behavior, in two different cultural contexts (i.e., Portugal and England), characterized by different religious affiliations. A sample (n = 725) comprising Portuguese (n = 312) and English (n = 413) adolescents and young adults completed an online survey. The findings indicated that Portuguese youth were more religious than their English counterparts. Moreover, religiosity was associated with lower gambling engagement among participants in both samples. Mediation analyses also showed that the cognitive distortion of illusion of control mediated the relationship between religiosity and problem gambling among the Portuguese participants, and the interpretative bias was a significant mediator in the English sample. The study’s findings suggest that religion can have a protective role on gambling behaviors. However, further research is needed to explore the interactive role of religion and cognitive distortions.