bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Optogenetic and Electrical Stimulation of Retinal Ganglion Cells for Artificial Vision
Authors: Kwan William , Brunton Emma , Begeng James , Kameneva Tatiana , Stoddart Paul , Ibbotson Michael , Richardson Rachael , Tong Wei 
Published: February 2024

Abstract

Millions of adults worldwide experience severe visual impairment due to photoreceptor loss from retinal diseases such as retinitis pigmentosa and macular degeneration. Retinal prostheses that provide artificial vision by stimulating the surviving retinal ganglion cells (RGCs) have emerged as a promising therapy. However, all clinically approved retinal prostheses that use electrical stimulation face the issue of electrical spread. As such, no device has been able to provide vision restoration beyond the threshold of legal blindness. Optogenetic approaches provide greater spatial precision, however, they have poor temporal fidelity compared to electrical stimulation. Questions remain over the safety of the high intensity light required. Here, we developed an opto-electrical hybrid approach that reduced optogenetic activation thresholds and increased the high frequency sensitivity of opsin expressing RGCs. Our findings suggest that incorporating hybrid stimulation in future retinal prostheses could dramatically improve high resolution vision.
Adaptive Finite-Time State-Feedback Control for Stochastic Nonlinear Systems with Input Saturation and Unknown Covariance Noise
Authors: Min Huifang 
Published: February 2024

Abstract
This paper focuses on the adaptive finite-time state-feedback control for more general stochastic nonlinear systems that are disturbed by unknown covariance noise, parametric uncertainties, and input saturation. To achieve this, the paper utilizes the adaptive control to handle the unknown covariance noise and parametric uncertainties. Additionally, an auxiliary signal is introduced to address the input saturation issue. By combining these techniques with the adaptive backstepping method, an adaptive state-feedback controller is constructed. The stability analysis shows that all signals within the closed-loop system are practically finite-time stable in probability. Furthermore, the output of the system can track the desired reference signal within a finite time. Finally, the effectiveness of the proposed controller is demonstrated through an example presented in the paper.
Mathematics Subject Classification (2020) MSC code1 · MSC code2 · more
β-Arrestin-2 enhances ER stress-induced glomerular endothelial cells injury through ATF6 in diabetic nephropathy
Authors: Liu Jiang , Song Xiaoyun , Li Xiuting , Yang Mu , Wang Fang , Han Ying , Jiang Ying , Lei Yuxin , Jiang Miao , Zhang Wen , Tang Dongqi 
Published: February 2024

Abstract
Background
Glomerular endothelial cell (GENC) injury would be a characteristic of early stage diabetic nephropathy (DN) and the investigation of potential therapeutic targets for preventing GENC injury has clinical importance.
Methods
DN was induced in C57BL/6J mice by intraperitoneal injection of streptozotocin. GENC was transfected with plasmid containing siRNA-β-arrestin-2, shRNA-ATF6, pCDNA-β-arrestin-2 or pCDNA-ATF6. Additionally, we administrated adeno-associated virus (AAV) containing shRNA-β-arrestin-2 via tail vein injection in DN mice.
Results
The upregulation of β-arrestin-2 was observed in DN patients as well as in GENC from DN mice. Knockdown of β-arrestin-2 reduced endoplasmic reticulum stress (ER stress) and apoptosis in high glucose treated GENC which were reversed by overexpression of activating transcription factor 6 (ATF6). Moreover, overexpression of β-arrestin-2 led to the activation of ER stress and the apoptosis of GENC which could be mitigated by silencing of ATF6. Furthermore, knockdown of β-arrestin-2 by the administration of AAV-shRNA-β-arrestin-2 had alleviated renal injury in DN mice.
Conclusions
This study offer novel perspectives on the crucial involvement of β-arrestin-2 in GENC injury. Knockdown of β-arrestin-2 prevents GENC apoptosis by inhibiting ATF6-mediated ER stress in vivo and vitro. Consequently, β-arrestin-2 may represent a promising therapeutic target for the clinical management of patients with DN.
Canola Protein Wood Adhesive with Improved Bonding properties
Authors: Tayo Lawrence Tene , Cárdenas-Oscanova Aldo Joao , Beulshausen Arne , Chen Lizhen , Euring Markus 
Published: February 2024

Abstract
The importance of creating eco-friendly and health-conscious materials has become paramount in striving to attain long term development gaols. For the past decades, constant efforts have been made to tackle the issue of formaldehyde release from wood-based panels which, to date, are still mainly produced using unsustainable synthetic adhesives. In the pursuit of sustainable and environmentally responsible adhesive solutions for the wood industry, sodium bisulfate, sodium bisulfite, and sodium nitrite were used as crosslinkers for canola protein-based bio-adhesive formulations with superior binding properties for the production of particleboards. The developed adhesive formulations showed outstanding mechanical properties, with a viscosity below 4000 mPa/s despite the relatively high solid content, as well as excellent bonding performances. The one-layer particleboards bonded with the canola-based adhesive exhibited excellent mechanical properties, with values of the internal bonding and the bending strength above 0.60 N/mm2 and 10 N/mm2 respectively of the sodium nitrite-treated variants being significantly greater than that of the UF-bonded control boards. the SEM analysis revealed a good crystallisation of the adhesive in the wood-binder matrix. The results of this research showcase not only the possibility of developing a plant protein-based wood adhesive with high solid content, but also the potential superiority of canola protein-based wood adhesives when compared to conventional, synthetic counterparts. This study is a milestone in the field of eco-friendly adhesive technologies, opening new horizons for sustainable wood-based materials.
Energy-Efficient Coverage Control in Clustered WPSNs
Authors: Yuan Lina , Chen Huajun Chen , Gong Jing , Wu Qiuman 
Published: February 2024

Abstract
Recently, the advancement of Wireless Powered Sensor Networks (WPSN) has garnered widespread attention. Due to the limited energy of sensor nodes, adopting efficient design to implement WPSN is highly necessary. The research on energy-efficient coverage control in Clustered WPSN (CWPSN) combined with the sixthgeneration wireless systems (6G) technology and artificial intelligence (AI) has brought new research opportunities and challenges to the field of wireless communication and sensor networks. This paper first introduces the architecture diagram and key technologies of CWPSN, then formulates a set coverage control problem, and proposes a Cluster-based Cooperative Medium Access (CoCMA) coverage control algorithm based on meme to solve the energysaving issue of set coverage control. Finally, the proposed CoCMA algorithm is compared to three other schemes through simulation using Matlab. The experimental results show that the CoCMA algorithm has a significant effect on enhancing the performance of CWPSN.
Influence of Thermal and Ultraviolet Ageing on a Polypropylene and Natural Rubber Blend
Authors: bendjaouahdou Chaouki 
Published: February 2024

Abstract
The literature relatively lacks results and data related to the direct influence of physical ageing on the properties of polypropylene and natural rubber blend. So, the objective of this research is to study the influence of thermal and ultraviolet (UV) ageing on a natural rubber (NR) SMR-ω and polypropylene (PP) blend. This toughened blend is generally used for the fabrication of automobile parts and in the construction industry. The loading of the NR was 10, 20, 30, 40 and 50 wt %. The blends were prepared by calendering followed by melt extrusion and it was subjected to XRD (WAXS) analysis, mechanical testing, thermal and UV ageing, and optical microscopy (OM) observations. The results obtained by X-ray characterisation show that the adding of this kind of rubber does not affect the crystalline structure of the polypropylene matrix. Moreover, the adding of the rubber shows a decrease of the obtained material tensile strength and a valuable increase of the elongation at break. The shore A hardness decrease slightly as the percentage of the natural rubber increase. The optical microscopy indicates the apparition of cracks at the sample surfaces and debonded rubber domains from polypropylene matrix induced by UV and thermal ageing.
A Comparative Meta-Analysis of Implant-Related Complications and Fusion Rates for the Atlantoaxial Fusion with Transarticular Screws and Screw-Rod Constructs.
Authors: Lvov Ivan , Grin Andrey , Talypov Aleksandr , Kordonskiy Anton , Barbakadze Zaali 
Published: February 2024

Abstract
Objectives. This study aims to conduct a comparative meta-analysis on the frequency of implant-related complications and fusion rates between screw-rod C1-C2 fusion (Goel-Harms technique, GHT) and transarticular atlantoaxial fusion (Magerl technique, TAF).
Methods. Following PRISMA guidelines, we conducted a systematic review. An initial search in the PubMed database yielded over 5,000 abstracts. Inclusion criteria were articles in English involving both TAF and GHT, patient age over 18 years, and studies reporting on fusion incidence and/or implant-related complications, published since January 1987.
Results. Sixteen studies met the inclusion criteria. The analysis revealed no significant differences in surgery duration (SMD = -0.21, 95% CI [-0.79, 0.37]) or intraoperative blood loss volume (SMD = 0.095, 95% CI [-0.41, 0.60]). Furthermore, no significant differences were observed between GHT and TAF concerning vertebral artery (VA) injury rate (OR 0.55, 95% CI [0.23 – 1.21]), screw malposition with VA canal perforation (OR 0.77, 95% CI [0.25 – 2.40]), screw malposition in other directions (OR 0.89, 95% CI [0.23-3.44]), C2 radiculopathy (OR 1.3, 95% CI [0.3 – 5.7]), implant failure (OR 0.49, 95% CI [0.16 – 1.46]), and fusion development (OR 1.97, 95% CI [0.93 – 4.16]). Begg's test indicated no publication bias.
Conclusion. This meta-analysis found no significant differences between the Goel-Harms and Magerl methods regarding operation duration, intraoperative blood loss, the incidence of postoperative implant-related complications, and C1-C2 fusion rates. Further research, especially studies with a higher evidence level, is vital to develop guidelines for the most effective atlantoaxial stabilization method.
Spontaneous polymer alignment enabling the synthesis of oriented 2D covalent organic framework films
Authors: Cusin Luca , Cieciórski Piotr , Gele Samuel Van , Heck Fabian , Krause Simon , Majewski Pawel W. , Lotsch Bettina V. , Danowski Wojciech , Samorì Paolo 
Published: February 2024

Abstract

Despite the rapid progress in the field of 2D polymerisation, the fabrication of high-quality films of 2D covalent organic frameworks (2D COFs) remains a longstanding challenge. Herein, we describe a two-stage method for preparing mechanically robust, large-area, porous, highly oriented, imine-linked 2D COF films from kinetically trapped, amorphous covalent adaptable network (CAN) films. The protonated imine-linked CANs are generated by solution casting and undergo an unusual spontaneous alignment in response to the tensile stresses emerging during the evaporation of the solvent. A subsequent amorphous-to-crystalline transformation proceeding under solvothermal conditions converts the 3D oriented networks to porous, free-standing 2D COF films. This protocol is applicable to a broad range of building units and a variety of 2D COF topologies. Our results provide a convenient and general synthetic tool for the assembly of high-quality 2D COFs films suitable for the construction of molecularly precise, oriented, robust, porous materials with tailorable properties.
The LowSugarBerry trait phenotyped at population and single fruit levels
Authors: Bigard Antoine , Berhe Dargie T. , Ojeda Hernan , Romieu Charles , Torregrosa Laurent 
Published: February 2024

Abstract
The grapevine is one of the most widely grown perennial crops worldwide. As for other species displaying clusters of small fruits, the development of single berries within a bunch is asynchronous and heterogeneous. Because of this, the study of water and solute accumulation kinetics and balance at the organ level cannot be directly extrapolated from samples of populations of fruits. In order to have an original and reliable dataset on the accumulation kinetics of the main solutes (primary and secondary metabolites and cations) and water, we analyzed fruit populations sorted according to their density and also individual berries from the onset of sugar importation to the end of phloem unloading. The studies were performed on a panel of varieties representing different metabolic contexts for the relationship between the import of organic and inorganic solutes and fruit growth, including genotypes able to import water at low fruit osmotic potential. These original data sets are suitable to revisit some aspects of the accumulation of main solutes and water in grapevine fruit development and/or to perform comparative studies with other fleshy fruits.
Screening and Functional Analysis of Differentially Expressed of shAPE1 in esophageal cancer cells based on RNA-seq
Authors: Chu Alan , Sun Chen , Liu Zongwen , Liu Shijia , Li Mengxi , Song Rui , Gan Lanlan , Wang Yongtai , Fan Ruitai 
Published: February 2024

Abstract
Purpose
To explore the impact of APE1 knockout on the transcriptome of esophageal cancer cells, and conduct a preliminary screening of target genes regulated by APE1, in order to provide a basis for clarifying APE1 target genes and finding new anti-esophageal cancer therapeutic targets.
Methods
TE-1 cells with APE1 knockout were used for transcriptome sequencing (RNA sequencing, RNA-Seq) detection, and GO and KEGG enrichment analysis of differentially expressed genes was performed. protein network interaction (PPI) analysis was performed on the differential genes, and qRT-PCR and Western blot experiments were used to verify the effect of knocking down APE1 on the expression levels of FN1, TNF and IL-6.
Results
RNA-seq analysis found that a total of 2060 differential genes were detected, including 1063 up-regulated genes and 997 down-regulated genes. GO and KEGG analysis revealed that the main enrichment pathway were metabolism, extracellular matrix, inflammatory response, and angiogenesis. PPI protein network analysis found that FN1, TNF and IL-6 may be important target genes of APE1. The three core genes were verified using qRT-PCR and Western blot.
Conclusion
The gene functions affected by APE1 gene knockout in esophageal cancer cells are mainly concentrated in pathways such as metabolism, extracellular matrix, inflammatory response, and angiogenesis. APE1 can promote the transcriptional expression of FN1 and IL6 genes and inhibit the TNF gene. FN1, TNF and IL-6 may be potential target genes regulated by APE1 in esophageal cancer.
Determinants of Postharvest Physical Losses in the Fish Value Chain: Evidence from Lake Hawassa, Sidama National Regional State, Ethiopia
Authors: Tunsisa Tekalign Tuluka , Dadi Ketema Bekele , Melesse Kumilachew Alamerie 
Published: February 2024

Abstract
Fish are valuable sources of nutrients necessary for physical and cognitive development and playvital roles in maintaining a healthy diet. However, the fish market faces challenges related to postharvest physical loss, which affects supply, food security, and fishermen's income. This study aimed to identify the factors contributing to postharvest physical loss within the fish value chain at Lake Hawassa. The data from 166 fishermen and 7 key informants were analyzedusing descriptive statistics such as the mean and standard deviation, along with the 2SLS model. The findings revealed that the average quantity loss was 5.99 kg per individual per day, signifying its significance in this context. Additionally, other key metrics included an average unit cost of ETB of 1.95, a unit price of ETB of 48.28, and an average daily fish catch of 45 kg. The 2SLS model output revealed that fish catch volume, access to market information, education, access to extension services, fish value addition, membership in a fishercooperative, distance from the landing site to the nearest market, and nonfarmincome significantly affected postharvest physical loss. Considering the significant impact of these factors on physical loss after harvest, it is imperative for policymakers to prioritize and allocate resources to enhancing access to market information, improving fishers' education, and strengthening extension services. Additionally, promoting value addition in the fishery sector and supporting the establishment of fisher cooperatives can play a crucial role in reducing postharvest losses and improving the overall economic conditions of fishers. Furthermore, investing in infrastructure to facilitate better access to markets can also contribute to minimizing physical losses and ensuring a steady supply of fish for consumers. By addressing these key factors, the government and relevant organizations can work toward creating a more sustainable and efficient fishery sector.
Systematic Review on Prevalence and Antimicrobial Resistance Patterns of Salmonella Isolates in Human Stools and Animal Origin Foods in Ethiopia
Authors: Yosef Dek Kahin 
Published: February 2024

Abstract
Background
Food borne diseases caused by non-Typhoidal Salmonella spp remains critical public health threat globally. Human Salmonellosis resulted in millions of deaths worldwide where developing countries such as Ethiopia are mostly affected. Nowadays, globally Salmonella spp isolated from human stools and animal origin foods exhibited wider antimicrobial resistance; in addition, multi-drug resistant salmonella strains have been reported from Sub-Saharan Africa. Therefore; the overall aim of this review is to qualitative summarize the available data of Salmonella spp from Human stool and animal origin foods in Ethiopia.
Method
systematical search of relevant literatures from three databases (PubMed, Google scholar and Science Direct) was carried out with regard of specific date of publications (2010–2021) in order to summarize the prevalence and antimicrobial susceptibility patterns of Salmonella spp from human stool and animal origin foods in Ethiopia.
Result
52 Research articles have fulfilled in the inclusion criteria of this systematic review and got included. 37 of them had been selected for prevalence of Salmonella spp whereas 15 of them had been chosen for antimicrobial susceptibility pattern. Most of the articles reported higher prevalence of salmonella isolates together with increased drug resistance. The prevalence of salmonella spp in articles targeting food handlers ranged from 1.2–9.04%. Articles focusing on children and U-5 children had a prevalence of salmonella spp ranging from 0.9–12.6%. Studies involving animal-related foods like Milk, Meat, and eggs reported a highest prevalence of 20% for salmonella species, followed by 16.4%.
Conclusion and Recommendation
after qualitative summarizing of the included articles, Salmonella spp shows higher prevalence (specifically among U-5 children followed by outpatients) and higher antibiotic resistance (particularly against Ampicillin followed by tetracycline) in Ethiopia. Therefore, early and accurate laboratory diagnosis with antimicrobial susceptibility pattern, hygienic practices improvement and appropriate use of antibiotics are highly recommended.
An Authentic Approach to Client-Server Communication Based on an Algorithmic Time-Bound Validation
Authors: Jain Vishal , Bhatt Monika , Patel Mayank , N.S.Rat  
Published: February 2024

Abstract
In sensitive communication, the genuineness of the data (messages) plays the most important role. Often, communication is misunderstood if the data are not validated before they are sent. This occurs because the data to be delivered can be typed incorrectly or because the data are fetched incorrectly (not in order) from the source where they are already stored. Therefore, in this paper, we introduce a new approach to client-server communication based on time-bound validation of the messages. This paper introduces an algorithm to overcome this issue. With respect to the algorithm, we propose a tricky approach that can be used by the client and the server to ensure the exchange of validated data (messages). The delivery of reviewed data ensures that no incorrect or misleading data are sent to the opposite side. The concept of a timer is therefore used in this research. The paper focuses on the validation of data from one of two sources: 1) a text file or 2) a keyboard (user input). By implementing the proposed algorithm, the server and the client can communicate with each other without any false interpretation of the data delivered. In this way, highly sensitive communication can occur successfully without any misunderstanding, which often arises because of the lack of reviewed data.
Iron, manganese, and lead contamination in groundwater of Bangladesh: a review
Authors: Islam Md. Zahidul , Mostafa M. G. 
Published: February 2024

Abstract
Groundwater is a vital source of safe drinking water in Bangladesh and most South Asian countries. The study aimed to identify the sources and assess the contamination of Fe, Mn, and Pb in groundwater. The study considered published articles, reports, and data repositories of concerned departments over the past two decades using various search engines, including Web of Science, Scopus, Science Direct, Google Scholar, etc. The study results showed the concentrations of Fe, Mn, and Pb in groundwater exceeded 55.93, 75.44, and 37.50%, respectively, of different standards, including the World Health Organization and United Nations Environmental Protection Agency. The concentrations of Fe, Mn, and Pb ranged from 0.003 to 16.6, 0.00063 to 3.11, and 0.0006 to 5.01 mg/L, respectively, and followed the order Fe &gt; Mn &gt; Pb in the groundwater of Bangladesh. Sources of Fe and Mn in groundwater are mostly geogenic in origin, while Pb contamination in groundwater is anthropogenic and derives from industry dust piles, vehicle exhaust discharge, lead pipes, faucets, fixtures, and batteries. The higher levels of heavy metals in groundwater cause health and environmental hazards. The study recommended that the higher concentrations of Fe, Mn, and Pb in groundwater make it unsuitable for drinking purposes and should be treated before consumption.
Anticoagulation in Patients with Atrial High-rate Episodes Detected by Cardiac
Implantable Electronic Devices
Authors: Spartalis Michael , Kontogiannis Christos , Spartalis Eleftherios , Iliopoulos Dimitrios C. , Siasos Gerasimos 
Published: February 2024

Abstract:
Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias that are identified by the use of continuous rhythm monitoring devices such as pacemakers, defibrillators, or implantable cardiac monitors. Nevertheless, the therapeutic implications of these rhythm disturbances remain uncertain. The presence of AHRE is associated with an increased risk of stroke as compared to patients who do not exhibit AHRE. The utilisation of
oral anticoagulation has the ability to mitigate the likelihood of stroke occurrence in patients with AHRE.
However, it is important to note that this treatment approach is also linked to a severe bleeding rate of approximately 2% per year. The stroke rate among individuals diagnosed with AHRE appears to be comparatively
lower when compared to patients diagnosed with atrial fibrillation. The efficacy and safety of anticoagulation
in patients with AHRE have yet to be definitively established. Further research is required to provide a comprehensive understanding of the effectiveness and safety of oral anticoagulation in individuals with AHRE.