bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pernicious liaisons: antibiotic-depressed immune response of a livestock micropredator, the common vampire bat (Desmodus rotundus)
Authors: Cabrera-Campos Iván , Ávila-Flores Rafael , Rivera-Ruiz David Alfonso , Herrera M. L. Gerardo 
Published: February 2025

Abstract
Antibiotics are pharmaceutical products with the potential to affect the immune performance of wildlife. Wildlife species might incorporate antibiotic residues in their system when feeding on livestock treated with these chemicals. One of the most studied interactions of livestock with wildlife is that established with the common vampire bat (Desmodus rotundus), which predates on livestock. We tested the effect of clindamycin on the humoral and cellular acquired immune responses of common vampire bats captured in the wild in Mexico. We hypothesized that both cellular and humoral acquired immune responses would be negatively affected after bats were exposed to clindamycin for 15 days. We measured local inflammation (swelling index = SI) and serum immunoglobulin concentration (IgG) after the repeated application of phytohemagglutinin (PHA) in bats treated with clindamycin and in a control group that did not receive the antibiotic. PHA is a plant lectin that induces mitosis in the effector cells of cellular-mediated immunity. We expected that antibiotic-exposed bats would present a weaker inflammatory response and that their IgG serum levels would not increase at the same rate after three consecutive injections of PHA than bats in the control group. Mean SI after the second injection of PHA was higher than that after the first injection only in bats in the control group. No significant difference was found in SI after the third injection with respect to the first injection in both the control and the experimental group. Mean IgG concentration was higher after the third injection than before the first injection only in vampire bats not treated with antibiotic. Our study shows the negative effect that exposure to anthropogenic chemicals generates on wildlife capacity to maintain a healthy immune system.
Young People’s Views of and Responses to Socioeconomic Inequality: Self-Oriented Accommodation, Sceptical Resistance and Knowing Resignation
Authors: Kim Chae-Young 
Published: February 2025

Abstract
To date, sociological research has rarely foregrounded young people’s views of the causes of socioeconomic inequality, either for interpreting their understanding of the underlying processes involved or for exploring how these may influence the choices that help shape their own future socioeconomic outcomes. To address this gap, this paper uses questionnaire and interview data from 77 UK secondary school students concerning the relationships between their views of the causes of wealth and poverty and their occupational aspirations. In particular, the paper looks at how holding a ‘critical’ view of inequality—i.e. one which sees structural factors as its main cause—impacts their attitudes toward achieving their aspirations. While most participants gave more than one kind of cause for both wealth and poverty, a minority gave only structural factors as the main cause. Among the participants who held such a critical view, I identify three types of response to inequality concerning their aspirations: self-oriented accommodation (endorsing meritocratic beliefs regarding their own career success), sceptical resistance (seeking upward mobility while simultaneously doubting its likelihood) and knowing resignation (an acceptance of the prospect of failing to achieve one’s aspirations). I then discuss how the potential transitions between these response types, especially for students from lower socioeconomic backgrounds, may contribute to the reproduction of inequality despite such a critical awareness. I conclude by highlighting the benefits of foregrounding young people’s views of the causes of inequality for understanding the mechanisms that underlie their choices and the subsequent socioeconomic outcomes.
Impact of broad ion beam center alignment and mask position on Si wafer cross-section milling rate
Authors: Won Jong-Han , Kim Ki-Hwan , Jang Dong-Young , Park Geon-Yeong 
Published: February 2025

Abstract
When processing an area over 500 µm in sample cross-section processing using an ion beam, Ar broad ion beam (Ar BIB) is used. Place a mask over the sample to be cross sectionized and irradiate Ar BIB on the specimen set higher than the mask. As the mask is cut, the cross section is processed in a form that follows the cross section. In the case of commercially available equipment based on Si wafer, the height on the specimen is set within 100 um above the mask, and the milling rate is defined as the result of processing for 1 h. It is generally known that during BIB processing, half of the beam is irradiated to the mask, and the remaining half is irradiated to the specimen for processing. However. in this study, it was found that the milling rate increased whenever the center of the beam was raised on the mask little by little (within a few ums to 100 um). From this study, the irradiation position of the BIB was raised on the mask surface at regular intervals for the experiment, and through this, the definition of the beam size of the DC plasma ion gun was used in the experiment, and the change in the milling rate of the Si wafer was studied.
Why Write Music? Scribes and Partial Notation in Toledo, Cathedral Archive, MS 35–6
Authors: Maloy Rebecca , Wride Emily 
Published: February 2025

Abstract
Western plainsong studies have typically focused on fully notated manuscripts, which provide the most complete witnesses to the repertories that have interested scholars in the field. Recent work, however, has shown that partially notated manuscripts, fragments, and marginalia can yield different kinds of insights into manuscript culture, as well as the uses and functions of musical notation. This article explores how a partially notated manuscript preserving the Old Hispanic rite, Toledo, Cathedral Archive, MS 35–6 (T6), can expand our knowledge of Old Hispanic chant, its scribal practices, manuscript culture, and notation. We identify the specific palaeographical traits and melodic dialects associated with each scribe. On this basis, we hypothesize that scribes used notation for a variety of reasons: to train in singing and writing, to practise writing, to correct particular melodies and notational forms, to preserve particular versions within a variant melodic tradition, and as an aide-memoire. T6 offers new insights into the various ways that the Old Hispanic oral tradition could be supported by writing.
The association between dietary inflammatory potential and risk of total and site-specific colorectal cancer: a systematic review and meta-analysis of observational studies
Authors: Nikparast Ali , Etesami Elahe , Shafiee Mahshad , Javaheri-Tafti Fatemeh , Mohajerani Arefeh , Ghanavati Matin 
Published: February 2025

Abstract
In the last decades, it has been well known that low grade inflammation plays a potential role in the pathogenesis of different cancers. The aim of this systematic review and meta-analysis of observational studies was to evaluate the association between inflammatory potential of diet measured through the Dietary Inflammatory Index (DII), energy-adjusted DII (E-DII), empirical dietary inflammatory pattern (EDIP) and inflammatory score of the diet (ISD) and risk of colorectal cancer (CRC) and site-specific colon cancer. A systematic electronic search of PubMed/Medline, Scopus, the Web of Sciences, and reference lists up to November 21, 2023, was performed. Data were pooled by the generic inverse variance method using random effect model. To assess the heterogeneity of included studies, the I2 index was used. A total of 28 original studies, comprising 2,287,836 participants, were selected to include in this meta-analysis. Pooled results showed a significant association between higher adherence to proinflammatory diet and increased risk of CRC (ES:1.39;95%CI:1.29-1.51;I2=82.9%), colon (ES:1.40;95%CI:1.26-1.55; I²= 73.3%, p<0.01), proximal colon (ES:1.28; 95% CI:1.17-1.40;I²=29.1%), distal (ES:1.50;95%CI:1.30-1.74;I²= 63.5%) and rectal (ES:1.46;95%CI:1.23-1.74;I²=80%). Stratified analysis by type of dietary indices noted that greater adherence to the DII, E-DII, and EDIP were related to significant increase in risk of overall CRC and site-specific colon cancers. Our results highlighted the proposed role of inflammatory protentional of diet as important risk factor for CRC. Adherence to an anti-inflammatory dietary pattern should be recommended to reduce incidence of CRC, globally.
Motion planning and searching strategy of a transverse ledge climbing robot based on force feedback
Authors: Pangestu Reno , Yu Guan Xian , Lin Chi-Ying 
Published: February 2025

Abstract
A transverse ledge climbing robot inspired by athletic locomotion is a customized robot aiming to travel through horizontal ledges in vertical walls. Due to the safety issue and complex configurations in graspable ledges such as horizontal, inclined ledges, and gaps between ledges, existing well-known vision-based navigation methods suffering from occlusion problems may not be applicable to this special kind of application. This study develops a force feedback-based motion planning strategy for the robot to explore and make feasible grasping actions as it continuously travels through reachable ledges. A contact force detection algorithm developed using a momentum observer approach is implemented to estimate the contact force between the robot’s exploring hand and the ledge. Then, to minimize the detection errors due to dynamic model uncertainties and noises, a time-varying threshold is integrated. When the estimated contact force exceeds the threshold value, the robot control system feeds the estimated force into the admittance controller to revise the joint motion trajectories for a smooth transition. To handle the scenario of gaps between ledges, several ledge-searching algorithms are developed to allow the robot to grasp the next target ledge and safely overcome the gap transition. The effectiveness of the proposed motion planning and searching strategy has been justified by simulation, where the four-link transverse climbing robot successfully navigates through a set of obstacle scenarios modeled to approximate the actual environment. The performance of the developed grasping ledge searching methods for various obstacle characteristics has been evaluated.
Comparison of morbidity and mortality outcomes of conventional and sutureless repair techniques in children with isolated total anomalous pulmonary venous drainage
Authors: Gözaçık Karakoç Kübra , Yazıcı Batuhan , Kamalı Hacer , Yıldız Okan , Karakoç Gökhan , Haydin Sertaç , Onan İsmihan Selen 
Published: February 2025

Abstract

Objectives:
The sutureless repair technique has been favoured due to its purported reduction in post-operative pulmonary venous obstruction rates. This study aims to compare the outcomes of conventional versus sutureless repair techniques in Total Anomalous Pulmonary Venous Drainage.

Methods:
In this retrospective single-centre analysis (2012–2022), we evaluated children who underwent conventional or sutureless repair for isolated total anomalous pulmonary venous drainage, excluding complex cardiac anomalies and incomplete data. Patients were categorised into conventional (Group C, n = 58) and sutureless (Group S, n = 41) groups. Primary outcomes included mortality, morbidity, and post-operative complications. Statistical analysis included Mann–Whitney U, chi-square, and Fisher’s exact tests where appropriate.

Results:
Supracardiac type predominated in both groups (53.4% in Group C and 70.7% in Group S), with higher cardiac type frequency in Group C (24.1% versus 2.4%, p = 0.016). Early complications occurred in 58.5% versus 53.4% of cases in Groups S and C, respectively (p = 0.767). The mortality rate (17.2% versus 14.6%, p = 0.944) and post-operative pulmonary venous obstruction (21.2% versus 19.0%, p = 0.809) were higher in Group C, though not significantly. Mean cardiopulmonary bypass times were comparable between groups (105 versus 89 minutes, p = 0.424).

Conclusions:
In this comprehensive analysis of paediatric Total Anomalous Pulmonary Venous Drainage repair, both conventional and sutureless techniques demonstrated comparable safety profiles and clinical outcomes. These findings suggest that surgical approach selection should be individualised based on patient characteristics and surgeon expertise. Further prospective studies with larger cohorts are needed to validate these observations.
Liquidity trap, private behavior preference, and the micro-foundation of fiscal multiplier dynamics
Authors: Chen Chuanglian , Dong Feng , Gao Xirong , Xu Jinhui 
Published: February 2025

Abstract
We incorporate the liquidity trap and private behavioral preferences into a New Keynesian dynamic stochastic general equilibrium model to analyze fiscal multipliers. The results indicate that the influence of the liquidity trap on fiscal policy is driven by a combination of the interest rate transmission effect and the precautionary savings effect, showing a notable amplification of multipliers based on estimates from U.S. data. Furthermore, we examine two types of private behavioral preferences: habit formation and investor confidence. Habit formation significantly boosts short-term government spending multipliers while exhibiting diverse impacts on different types of taxation. Compared to superficial habits, deep habits result in flatter multiplier curves. Investor confidence, being highly sensitive to output fluctuations, enhances both spending and tax multipliers over the medium to long term. Additionally, the investor confidence channel slightly amplifies the expansionary effect of the liquidity trap on multipliers, contrasting with the impact of habit formation.
Bankfull and Mean‐Flow Channel Geometry Estimation Through Machine Learning Algorithms Across the CONtiguous United States (CONUS)
Authors: Zarrabi Reihaneh , McDermott Riley , Erfani Seyed Mohammad Hassan , Cohen Sagy 
Published: February 2025

AbstractWidely adopted models for estimating hydraulic geometry attributes rely on simplistic power‐law equations, which can introduce inaccuracy due to their inability to capture spatial variability. This study introduces a new model for predicting channel geometry utilizing advanced tree‐based Machine Learning (ML) algorithms. The research enhances the quality of the extensive HYDRoacoustic data set supporting Surface Water Oceanographic Topography (HYDRoSWOT) through a proposed preprocessing method. Observations of bankfull and mean‐flow conditions at each gauge site are identified and extracted as target variables for model development. HYDRoSWOT‐extracted attributes, along with other predictors from various sources, such as National Hydrography Data set Plus (NHDPlusV2.1), are used to train and validate predictive models. The models achieve average R2 values of 0.85 for channel width and 0.69 for channel depth, demonstrating high accuracy in capturing spatial variability in hydraulic geometry attributes. Independent evaluations further test the models' performance in predicting reach‐averaged conditions at locations outside the training and testing data sets. The results show that the proposed model significantly outperforms existing regional hydraulic geometry relations, with accuracy improvements of 30% for bankfull width and 76% for bankfull depth. The proposed model is then utilized to generate channel width and depth under bankfull and mean‐flow conditions data set across approximately 2.7 million streams within NHDPlusV2.1 data set across the CONtiguous United State (CONUS). This data set is a valuable resource for water‐related sciences, including hydrology, geomorphology, flood modeling, water quality assessment, and flood management.
Golgi condensation causes intestinal lipid accumulation through HIF-1α-mediated GM130 ubiquitination by NEDD4
Authors: Kim Hyunsoo , Park Channy , Wei Xiaofan , Chhetri Arun , Manandhar Laxman , Jang Gyuho , Hwang Jaetaek , Chinbold Batchingis , Chuluunbaatar Chagtsalmaa , Kwon Hyug Moo , Park Raekil 
Published: February 2025

Abstract
The breakdown of Golgi proteins disrupts lipid trafficking, leading to lipid accumulation in the small intestine. However, the causal mechanism of the effects of Golgi protein degradation on the Golgi structure related to lipid trafficking in the small intestine remains unknown. Here we find that Golgi protein degradation occurs under hypoxic conditions in high-fat-diet-fed mice. Hypoxia-induced degradation promotes structural changes in the Golgi apparatus, termed ‘Golgi condensation’. In addition, hypoxia-inducible factor 1α (HIF-1α) activation enhances Golgi condensation through the ubiquitination and degradation of Golgi matrix protein 130 (GM130), which is facilitated by neural precursor cell expressed developmentally downregulated protein 4 (NEDD4). Golgi condensation upon exposure to hypoxia promotes lipid accumulation, apolipoprotein A1 retention and decreased chylomicron secretion in the intestinal epithelium. Golgi condensation and lipid accumulation induced by GM130 depletion are reversed by exogenous GM130 induction in the intestinal epithelium. Inhibition of either HIF-1α or NEDD4 protects against GM130 degradation and, thereby, rescues cells from Golgi condensation, which further increases apolipoprotein A1 secretion and lipid accumulation both in vivo and in vitro. Furthermore, the HIF-1α inhibitor PX-478 prevents Golgi condensation, which decreases lipid accumulation and promotes high-density lipoprotein secretion in high-fat-diet-fed mice. Overall, our results suggest that Golgi condensation plays a key role in lipid trafficking in the small intestine through the HIF-1α- and NEDD4-mediated degradation of GM130, and these findings highlight the possibility that the prevention of structural modifications in the Golgi apparatus can ameliorate intestinal lipid accumulation in obese individuals.
Emerging roles of extracellular vesicles in oral and maxillofacial areas
Authors: Wang Qianting , Sun Jiayu , Jiang Haci , Yu Mengfei 
Published: February 2025

Abstract
The oral and maxillofacial region is a highly complex area composed of multiple tissue types and bears various critical functions of the human body. Diseases in this region pose significant diagnostic and management challenges; therefore, exploring new strategies for early diagnosis, targeted treatment, and tissue reconstruction is key to improving patient prognosis and quality of life. Extracellular vesicles are a group of heterogeneous lipid-bilayer membrane structures secreted by most cell types, including exosomes, microvesicles, and apoptotic bodies. Present in various body fluids and tissues, they act as messengers via the transfer of nucleic acids, proteins, and metabolites to recipient cells. To date, studies have revealed the different roles of extracellular vesicles in physiological or pathological processes, as well as applications in disease diagnosis, prognosis, and treatment. The importance and tissue specificity of the dental and maxillofacial tissues indicate that extracellular vesicles derived from this region are promising for further research. This paper reviews the published data on extracellular vesicles derived from cells, body fluids, and tissues in oral and maxillofacial regions, summarizes the latest advances in extracellular vesicles from extensive sources, and concludes with a focus on the current research progress and application prospects of engineered exosomes in oral science.
Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway
Authors: Guo Dongling , Du Yu , Liu Xin , Li Dan , Wei Ling , Zhu Xiangjia 
Published: February 2025

Abstract
Highly myopic cataract (HMC) is a leading cause of blindness among the working-age individuals, with its pathogenesis poorly understood. This study aimed to elucidate the role of ferroptosis in HMC development as well as the underlying mechanisms. In HMC lens epithelia, levels of Fe2+ and lipid peroxidation were found elevated, with increased vulnerability towards ferroptosis as revealed by transmission electron microscopy. Mechanistically, RNA sequencing of HMC lens epithelial samples identified up-regulated expression of discoidin domain receptor tyrosine kinase 2 (DDR2) as a key factor, which could enhance ferroptosis sensitivity via the Src-Hippo pathway. Specifically, DDR2 interacted with Src kinase, leading to the nuclear translocation of homologous transcriptional regulators (yes-associated protein 1 [YAP1] and WW domain containing transcription regulator 1 [WWTR1]) of the Hippo pathway, which altered the expression level of ferroptosis-related genes. Notably, highly myopic eyes of mice exhibited higher sensitivity to RSL3, a ferroptosis inducer, manifested as more severe nuclear lens opacities both in vitro and in vivo compared with the contralateral control eyes, which could be alleviated by inhibitors of either ferroptosis or DDR2. Altogether, these findings highlighted the role of DDR2 in mediating ferroptosis in HMC formation, providing a novel insight for therapeutic interventions.
A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types
Authors: Zeng Zhen , Zhang Tianbei , Zhang Jiajia , Li Shuai , Connor Sydney , Zhang Boyang , Zhao Yimin , Wilson Jordan , Singh Dipika , Kulikauskas Rima , Church Candice D. , Pulliam Thomas H. , Jani Saumya , Nghiem Paul , Topalian Suzanne L. , Forde Patrick M. , Pardoll Drew M. , Ji Hongkai , Smith Kellie N. 
Published: February 2025

Abstract
Identifying tumor-specific T cell clones that mediate immunotherapy responses remains challenging. Mutation-associated neoantigen (MANA) -specific CD8+ tumor-infiltrating lymphocytes (TIL) have been shown to express high levels of CXCL13 and CD39 (ENTPD1), and low IL-7 receptor (IL7R) levels in many cancer types, but their collective relevance to T cell functionality has not been established. Here we present an integrative tool to identify MANA-specific TIL using weighted expression levels of these three genes in lung cancer and melanoma single-cell RNAseq datasets. Our three-gene “MANAscore” algorithm outperforms other RNAseq-based algorithms in identifying validated neoantigen-specific CD8+ clones, and accurately identifies TILs that recognize other classes of tumor antigens, including cancer testis antigens, endogenous retroviruses and viral oncogenes. Most of these TIL are characterized by a tissue resident memory gene expression program. Putative tumor-reactive cells (pTRC) identified via MANAscore in anti-PD-1-treated lung tumors had higher expression of checkpoint and cytotoxicity-related genes relative to putative non-tumor-reactive cells. pTRC in pathologically responding tumors showed distinguished gene expression patterns and trajectories. Collectively, we show that MANAscore is a robust tool that can greatly enrich candidate tumor-specific T cells and be used to understand the functional programming of tumor-reactive TIL.