bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between changed self-rated health and the risk of venous thromboembolism in Malmö Preventive Program: a cohort study
Authors: Nymberg Peter , Milos Nymberg Veronica , Calling Susanna , Engström Gunnar , Svensson Peter , Elf Johan , Zöller Bengt 
Published: January 2024

AbstractPoor self-rated health (SRH) is associated with incident arterial cardiovascular disease in both sexes. Studies on the association between SRH and incident venous thromboembolism (VTE) show divergent results in women and no association in men. This study focuses on the association between change in SRH and incident VTE in a cohort of 11,558 men and 6682 women who underwent a baseline examination and assessment of SRH between 1974 and 1992 and a re-examination in 2002–2006. To investigate if changes in SRH over time affect the risk of incident VTE in men and women. During a follow-up time from the re-examination of more than 16 years, there was a lower risk for incident VTE among women if SRH changed from poor at baseline to very good/excellent (HR 0.46, 95% CI 0.28; 0.74) at the re-examination. Stable good SRH (good to very good/excellent at the re-examination, HR 0.60, 95% CI 0.42; 0.89), or change from good SRH at baseline into poor/fair at the re-examination (HR 0.68, 95% CI 0.51; 0.90) were all significantly associated with a reduced risk for VTE. All comparisons were done with the group with stable poor SRH. This pattern was not found among men. Regardless of a decreased or increased SRH during life, having an SRH of very good/excellent at any time point seems to be associated with a decreased risk of VTE among women.
Translatability of mouse muscle-aging for humans: the role of sex
Authors: de Jong Jelle C. B. C. , Caspers Martien P. M. , Worms Nicole , Keijzer Nanda , Kleemann Robert , Menke Aswin L. , Nieuwenhuizen Arie G. , Keijer Jaap , Verschuren Lars , van den Hoek Anita M. 
Published: January 2024

AbstractMuscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have sex-specific features in humans, but it is not yet assessed whether these are recapitulated in mice. Here, we studied the effects of aging on a functional, histological and transcriptional level at multiple timepoints in male and female mice (4, 17, 21 and 25 months), with particular emphasis on sex-differences. The effects of natural aging on the transcriptome of quadriceps muscle were compared to humans on pathway level. Significant loss of muscle mass occurred late, at 25 months, in both male (-17%, quadriceps) and female mice (-10%, quadriceps) compared to young control mice. Concomitantly, we found in female, but not male mice, a slower movement speed in the aged groups compared to the young mice (P < 0.001). Consistently, weighted gene co-expression network analysis revealed a stronger association between the aging-related reduction of movement and aging-related changes in muscle transcriptome of female compared to male mice (P < 0.001). In male, but not female mice, major distinctive aging-related changes occurred in the last age group (25 months), which highlights the necessity for careful selection of age using mice as a muscle-aging model. Furthermore, contrasting to humans, more aging-related changes were found in the muscle transcriptome of male mice compared to female mice (4090 vs. 2285 differentially expressed genes at 25 months, respectively). Subsequently, male mice recapitulated more muscle-aging related pathways characteristic for both male and female humans. In conclusion, our data show that sex has a critical effect on the mouse muscle-aging trajectory, although these do not necessarily reflect sex differences observed in the human muscle-aging trajectory.
Future Skills – Zukunftsorientierte Hochschullehre
Authors: Zahn Carmen 
Published: January 2024

ZusammenfassungIn diesem Theoriebeitrag der Zeitschrift für Psychodrama und Soziometrie wird ein wissenschaftliches Erklärungsmodell für die Wirksamkeit psychodramatischer Methoden in der Hochschullehre entwickelt. Eine zukunftsfähige Hochschullehre, die bei Studierenden neben dem Erlernen komplexer Wissens- und Handlungszusammenhänge auch mit fundierten Methoden die Kreativität, Innovationsfreude und „Future skills“ fördert, ist wichtiger denn je.
Germline Mutations and Ancestry in Prostate Cancer
Authors: Bataba Eudoxie , Babcock Kevin , Isensee Kathryn A. , Eldhose Binil , Kohaar Indu , Chesnut Gregory T. , Dobi Albert 
Published: January 2024

Abstract
Purpose of Review
Prostate cancer is the most frequently diagnosed non-cutaneous malignancy of men in the USA; notably, the incidence is higher among men of African, followed by European and Asian ancestry. Germline mutations and, in particular, mutations in DNA damage repair genes (DDRGs) have been implicated in the pathogenesis of prostate cancer. This review intends to discuss the implication of ancestry on prostate cancer, specifically in regard to lack of diversity in genomic and genetic databases and the ability of providers to properly counsel patients on the significance of cancer genetic results.

Recent Findings
Ancestral differences in prostate cancer-associated DDRG germline mutations are increasingly recognized. Guidelines for treatment by the National Comprehensive Cancer Network® (NCCN®) support germline testing in certain patients, and a myriad of genetic testing panels for DDRG mutations are now available in clinical practice. However, the consensus among providers on what genes and mutations to include in the genetic tests has evolved from experience from men of European ancestry (EA). Gaps in ancestry-informed clinical practice exist in genetic risk assessment, implementation of screening, counseling, guiding recommendations, treatment, and clinical trial enrollment.

Summary
The lack of diversity in tumor genomic and genetic databases may hinder ancestry-specific disease-predisposing alterations from being discovered and targeted in prostate cancer and, therefore, impede the ability of providers to accurately counsel patients on the significance of cancer genetic test results.
Anaerobic Co-digestion of the Liquid Fraction of Food Waste with Waste Activated Sludge
Authors: Kanellos Gerasimos , Tremouli Asimina , Kondylis Antonios , Stamelou Antigoni , Lyberatos Gerasimos 
Published: January 2024

AbstractThe present study investigated the feasibility of the anaerobic co-digestion (AcoD) of condensate, resulting from drying food waste, with Waste Activated Sludge in a pilot scale continuous stirred tank reactor. Different parameters were assessed in order to enhance the AcoD performance; the condensate potency (condensate A: 13 gCOD/L and condensate B: 4 gCOD/L), the volumetric ratio of condensate to WAS (0–67% v/v) and the hydraulic retention time (HRT) (20, 15 and 12 days). The results showed that increasing the condensate content in the feed from 0 to 67% v/v, enhances the organic load removal (up to 41% increased total COD removal) and the bioenergy production (up to 35% increased biomethane production). Moreover, in the case of condensate A, the reduction of HRT from 20 to 15 days enhanced the bioenergy production (up to 19% increased biomethane production) while the reduction of HRT from 20 to 12 days in the case of condensate B did not significantly affect the reactor’s performance. Overall it is concluded that condensate can be safely introduced in existing facilities for anaerobic digestion, while maintaining a more stable operation and improved effluent quality and bioenergy production in comparison with conventional anaerobic sludge digestion.
Graphical Abstract
On the electric behaviour of conductive grease inside the contact zone
Authors: Zhou Yuxin , Liu Jinjie , Li Xinming , Chong He , Han Bo , Bai Qinghua 
Published: January 2024

AbstractConductive grease has been considered as a potential solution in addressing electric erosion issue inside motor bearings. Understanding the conductive grease performance, especially the electric and tribological behaviour is crucial for its application. This paper combines bulk grease characterization and contact film study considering both electrical and tribological loading conditions. The results show that the electric performance for the selected conductive grease sample is electric field dependent, including both frequency and voltage amplitude. Its film impedance inside the contact area is closely related to the external electric field, running condition, and lubrication regime. The following film impedance calculation tells that not only bulk grease electric parameters, but the contact parameter, lubricant film contour and lubrication condition should be considered when performing the overall bearing electrical modelling.
Roof movement and instability fracture characteristics in shallow-buried thin coal seam conventional mining faces
Authors: Zhang Jihua , Rui Qiao , Yang Yushun , Chen Jiarui , Shen Wei , Yuan Yue , Wang Chengwu , Liu Weili 
Published: January 2024

AbstractThe variation in the width of the mining face significantly affects the stability of the face, leading to potential roof fracturing and collapse. Additionally, strong mining pressure can manifest, severely impeding the safe production of coal mines. This study uses the No. 16705 conventional working face of Jinda Coal Mine as its engineering background to investigate the characteristics of roof strata movement and instability under conditions of variable-width mining in shallow-buried thin coal seams. First, the dynamic load of the roof strata is estimated based on the key strata theory. Next, a mechanical model of the immediate roof strata movement in the working face is established based on the theory of elastic thin plates, which has been used to reveal the impact of different dimensions of the overhanging plate structure and residual overhanging structures in the corner on roof movement and its associated fracture mechanics. The findings indicated that the maximum bending deformation, deformation moment, and bending stress all have an exponential function relationship with the roof width. Similarly, these metrics have an exponential function relationship with the overhanging span of the roof. In addition, these parameters all have a linear functional relationship with the size of the residual overhanging structures in the corner. Finally, the effect of roof instability on overlying pressure is analyzed, and both the initial fracture step length and cyclic movement fracture step length of the roof are estimated. These insights offer valuable scientific guidance and a theoretical foundation for analyzing the adaptability of load-bearing pillars pressure in thin coal seam mining faces, bearing significant relevance to safety production.
Zur Anbahnung diskursiven Unterrichts in der Grundschule. Theoretische und empirische Anregungen zur Begründung und Etablierung einer postheroischen Lehr-Lern-Form
Authors: Goldmann Daniel 
Published: January 2024

ZusammenfassungDer Beitrag untersucht anhand von Unterrichtstranskripten einen diskursiven Grundschulunterricht, der anhand des systemtheoretischen Begriffsvorschlags der Lernkonflikte als kategorial andere Unterrichtsweise identifizierbar ist. Der Unterricht wird daraufhin befragt, welche Mittel und dahinterliegenden Strategien der Anbahnung und Etablierung eines solchen Unterrichts im Verlauf der Grundschulzeit rekonstruiert werden können. Die identifizierten Strategien können gleichzeitig als Grundlage für die Etablierung eines solchen Lehrformats in anderen Schulformen oder der universitären Lehre dienen.
All the Earth will not remember: how geographic gaps structure the record of diversity and extinction
Authors: Krone Isaac W. , Magoulick Katherine M. , Yohler Ryan M. 
Published: January 2024

AbstractWe know the fossil record is incomplete, but just how much biodiversity does it miss? We produce the first geographically controlled estimate by comparing the geographic ranges of 34,266 modern tetrapods with a map of the world's sedimentary basins. By modeling which tetrapods live within sedimentary basins, we produce a first-order estimate of what might be found in the fossil record of the future. In this record, nearly 30% of tetrapod species have almost no chance of fossilizing, and more stringent criteria for fossilization exclude far more diversity. This geographically structured fossil record preserves disparate patterns of taxonomic and phylogenetic diversity in different tetrapod groups and underpreserves projected extinctions. For the globally threatened amphibians, the magnitude of the extinction of all endangered species would be underestimated by 66–98% in our future record. These results raise profound questions about the structure of the fossil record. Is it capable of recording major origination and extinction events on land? Have swaths of terrestrial diversity gone unrecorded based on geography alone? There are chapters of Earth history that paleontologists can never hope to know, but what is missing, and why?
Species occurrences of Mio-Pliocene horses (Equidae) from Florida: sampling, ecology, or both?
Authors: Killingsworth Stephanie R. , MacFadden Bruce J. 
Published: January 2024

AbstractDuring the late Miocene and early Pliocene (latest Hemphillian, Hh4 interval, 5.7 to 4.75 Ma) a distinctive suite of four species of extinct horses (Family Equidae) were widespread in North America. This includes Nannippus aztecus, Neohipparion eurystyle, Astrohippus stocki, and Dinohippus mexicanus. In Florida, two additional equid species, Pseudhipparion simpsoni and Cormohipparion emsliei, are also typically found at Hh4 localities. Here we compare horses from four Hh4 Florida fossil sites, including three from the Bone Valley mines and a fourth from the recently discovered Montbrook site. Two of these sites have all six expected species, one has five species, and one has only four species present. To explain these differences, we used species counts from research databases and rarefaction simulation to clarify the relative abundances, species richness, and occurrences of these horses from these four sites. The Palmetto Mine (Agrico) site, with five equid species, appears to lack the sixth species owing to ecological reasons. This is different from Montbrook, the site with only four of the six species. Results indicate that Montbrook is likely lacking two missing equid species for a couple of reasons: sampling bias and biological/ecological causes. Our results demonstrate that sampling biases can account for observed equid species richness when the overall abundance of certain equid species is low. Nevertheless, other factors, including ecology and with sufficient resolution, perhaps also time, may also explain the distribution and occurrences of individual species at these and other fossil sites. In a broader perspective, analyses such as this example provide an opportunity to address a persistent challenge in paleontology, that is, how do we explain absences of extinct taxa from the fossil record?
CHALCOLITHIC/EARLY BRONZE AGE AND ADDITIONAL MAGDALENIAN RADIOCARBON DATES FOR EL MIRÓN CAVE (RAMALES DE LA VICTORIA, CANTABRIA, SPAIN). DATE LIST VII
Authors: González Morales Manuel R , González-Rabanal Borja , Gutiérrez-Zugasti Igor , Cuenca-Solana David , Straus Lawrence G 
Published: January 2024

ABSTRACTThere are now 101 radiocarbon dates from the long Paleolithic and post-Paleolithic culture-stratigraphic sequence in El Mirón Cave, Cantabrian Spain. Here we report on two dates on bone from two different humans whose remains were found in disturbed surface sediments in the cave vestibule rear and that confirm the existence of burials in addition to previously reported residential occupations in the vestibule front pertaining to the Chalcolithic and early Bronze Age periods (ca. 5500–3500 cal BP). In another attempt to resolve problems of stratigraphic incoherence of dates from the early Magdalenian periods in the vestibule rear, six new assays on faunal remains from Levels 119, 117, 114, 108, and 106 were run at Queen’s University in Belfast. There continue to be date inversions in the Lower Magdalenian range of levels that may be explained by a combination of intensive anthropic and rodent activity, major rock fall, slope wash and gravity-caused object movements, as well as possible problems in following some thin levels during excavations over a large area and across many years of work in the cave vestibule interior, particularly in the absence of any layers that are culturally sterile or even poor. Nonetheless, the coherent age of the Initial Magdalenian is fully confirmed by a new date from Level 21 in the vestibule front at ca. 22,000–20,500 cal BP), as is the general age range of the Lower Magdalenian (ca. 20,500–18,000 cal BP).
Effects of co-infection with Clonorchis sinensis on T cell exhaustion levels in patients with chronic hepatitis B
Authors: Dong Huimin , Liao Yuan , Shang Mei , Fu Yuechun , Zhang Hongbin , Luo Minqi , Hu Bo 
Published: January 2024

Abstract
To investigate the effects of co-infection with Clonorchis sinensis (C. sinensis) on T cell exhaustion levels in patients with chronic hepatitis B, we enrolled clinical cases in this study, including the patients with concomitant C. sinensis and HBV infection. In this study, we detected inhibitory receptors and cytokine expression in circulating CD4+ and CD8+ T cells by flow cytometry. PD-1 and TIM-3 expression levels were significantly higher on CD4+ T and CD8+ T cells from co-infected patients than on those from the HBV patients. In addition, CD4+ T cells and CD8+ T cells function were significantly inhibited by C. sinensis and HBV co-infection compared with HBV single infection, secreting lower levels of Interferon gamma (IFN-γ), Interleukin-2 (IL-2), and TNF-α. Our current results suggested that C. sinensis co-infection could exacerbate T cell exhaustion in patients with chronic hepatitis B. PD-1 and TIM-3 could be novel biomarkers for T cell exhaustion in patients with Clonorchis sinensis and chronic hepatitis B co-infection. Furthermore, it may be one possible reason for the weaker response to antiviral therapies and the chronicity of HBV infection in co-infected patients. We must realize the importance of C. sinensis treatment for HBV-infected patients. It might provide useful information for clinical doctors to choose the right treatment plans.
A contact parameter estimation method for multi-modal robot locomotion on deformable granular terrains
Authors: Lyu Shipeng , Zhang Wenyao , Yao Chen , Liu Zhengtao , Su Yang , Zhu Zheng , Jia Zhenzhong 
Published: January 2024

AbstractIn this paper, we consider the problem of contact parameters (slippage and sinkage) estimation for multi-modal robot locomotion on granular terrains. To describe the contact events in the same framework for robots operated at different modes (e.g., wheel, leg), we propose a unified description of contact parameters for multi-modal robots. We also provide a parameter estimation method for multi-modal robots based on CNN and DWT (discrete wavelet transformation) techniques and verify its effectiveness over different types of granular terrains. Besides motion modes, this paper also considers the influence of slope angles and the robot’s handing angles over contact parameters. Through comparison and analysis of the prediction results, our method can not only effectively predict the contact parameters of multi-modal robot locomotion on a granular medium (better than
$96\%$
accuracy) but also achieves the same or better performance when compared to other (direct) contact measurement methods designed for individual motion modes, that is, single-modal robots such as quadruped robots and mars rovers. Our proposed unified contact parameter estimation method can be useful for studying the interaction mechanics between multi-modal robots and granular terrains as well as terrain classification tasks due to its superior sensitivity which is analyzed in the experiments.
Trends of risk factors associated with childhood stunting and anaemia in Ghana: evidence from the Demographic Health Survey and Multiple Indicator Cluster Survey (2003–2017)
Authors: Sewor Christian , Jayalakshmi Rajeev 
Published: January 2024

Abstract

Objective:
This study investigated the trend of effect estimates of the key risk factors of childhood stunting and anaemia between 2003 and 2017.

Design:
A secondary analysis of the Demographic Health Survey (DHS) and Multiple Indicator Cluster Survey (MICS) data for the Ghanaian population between 2003 and 2017. Associations of selected socio-demographic (child age and gender; maternal age and education), economic (household wealth), environmental, dietary (minimum dietary diversity and iodine use) and health system (place of delivery and vaccination) factors were explored using the Poisson regression model. Trend analysis was explored using a fitted linear regression line on a time series plot.

Setting:
Ghana

Participants:
Children under 5 years

Results:
The results showed a reduction in the prevalence of stunting and anaemia over the 15-year duration. These health outcomes were found to be negatively associated with a wide array of socio-demographic (child age and gender, maternal age and education, residency), economic (household wealth), dietary (iodised salt use) and health service (place of delivery and vaccination) factors; however, the most consistent statistically significant association was observed between child’s age and belonging to the poor wealth quintile.

Conclusion:
In order to prevent these indicators of child malnutrition, key consideration must be given to the early developmental stages of life. Child health policies must focus on addressing the key contextual factors of child malnutrition.
Gamma Knife treatment strategies for paediatric AVMs: approaches to refractory cases
Authors: Horiba A. , Hayashi M. , Oka M. , Funatsu T. , Ishikawa T. , Yamaguchi K. , Kawamata T. 
Published: January 2024

AbstractIntroduction:While paediatric arteriovenous malformations (AVMs) often require aggressive therapeutic intervention due to their high bleeding incidence, choosing a course of treatment for deep and eloquent areas and asymptomatic cases is difficult. Sequelae are a concern in children, as they survive for longer after treatment. The authors have long recommended and implemented staged Gamma Knife radiosurgery (GKRS) in their treatment guidelines to maximise therapeutic effects.Methods:Fifty-eight paediatric patients with AVM and ≤15 years old who underwent GKRS under general anesthesia from 2002 to 2020 were followed up for an average of 81·5 months. Obliteration dynamics and clinical outcomes were analysed.Results:The mean patient age was 10·5 years. The mean nidus volume was 6·6 cm3, the complete occlusion rate was 69%, the annual post-irradiation bleeding rate was 2·19% and nine (16%) cases had transient radiation-induced changes. One (1·7%) patient had sequela, and three (5·1%) developed encapsulated hematomas and cysts. Additionally, the 3- and 5-year cumulative occlusion rates were 39·0% and 53·3%, respectively. Multivariate analysis showed significantly higher occlusion rates in patients ≤12 years old and with a nidus volume of ≤4 cm3.Conclusions:GKRS is a useful treatment for paediatric AVM; however, its use poses some challenges.