bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trunk muscle activity during bridging exercises on and off a Swissball
Authors: Lehman Gregory J , Hoda Wajid , Oliver Steven 
Published: July 2005

Abstract

Background

A Swiss ball is often incorporated into trunk strengthening programs for injury rehabilitation and performance conditioning. It is often assumed that the use of a Swiss ball increases trunk muscle activity. The aim of this study was to determine whether the addition of a Swiss ball to trunk bridging exercises influences trunk muscle activity.

Methods

Surface electrodes recorded the myoelectric activity of trunk muscles during bridging exercises. Bridging exercises were performed on the floor as well as on a labile surface (Swiss ball).

Results and Discussion

During the prone bridge the addition of an exercise ball resulted in increased myoelectric activity in the rectus abdominis and external oblique. The internal oblique and erector spinae were not influenced. The addition of a swiss ball during supine bridging did not influence trunk muscle activity for any muscles studied.

Conclusion

The addition of a Swiss ball is capable of influencing trunk muscle activity in the rectus abdominis and external oblique musculature during prone bridge exercises. Modifying common bridging exercises can influence the amount of trunk muscle activity, suggesting that exercise routines can be designed to maximize or minimize trunk muscle exertion depending on the needs of the exercise population.
Hepascore: An Accurate Validated Predictor of Liver Fibrosis in Chronic Hepatitis C Infection
Authors: Adams Leon A , Bulsara Max , Rossi Enrico , DeBoer Bastiaan , Speers David , George Jacob , Kench James , Farrell Geoffrey , McCaughan Geoffrey W , Jeffrey Gary P 
Published: July 2005

AbstractBackground: Staging hepatic fibrosis by liver biopsy guides prognosis and treatment of hepatitis C, but is invasive and expensive. We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients.Methods: Ten biochemical markers were measured at time of liver biopsy in 117 untreated hepatitis C patients (training set). Multivariate logistic regression and ROC curve analyses were used to create a predictive model for significant fibrosis (METAVIR F2, F3, and F4), advanced fibrosis (F3 and F4), and cirrhosis (F4). The model was validated in 104 patients from other institutions.Results: A model (Hepascore) of bilirubin, γ-glutamyltransferase, hyaluronic acid, α2-macroglobulin, age, and sex produced areas under the ROC curves (AUCs) of 0.85, 0.96, and 0.94 for significant fibrosis, advanced fibrosis, and cirrhosis, respectively. In the training set, a score ≥0.5 (range, 0.0–1.0) was 92% specific and 67% sensitive for significant fibrosis, a score &lt;0.5 was 81% specific and 95% sensitive for advanced fibrosis, and a score &lt;0.84 was 84% specific and 71% sensitive for cirrhosis. Among the validation set, the AUC for significant fibrosis, advanced fibrosis, and cirrhosis were 0.82, 0.90, and 0.89, respectively. A score ≥0.5 provided a specificity and sensitivity of 89% and 63% for significant fibrosis, whereas scores &lt;0.5 had 74% specificity and 88% sensitivity for advanced fibrosis.Conclusions: A model of 4 serum markers plus age and sex provides clinically useful information regarding different fibrosis stages among hepatitis C patients.
Microphthalmia with linear skin defects (MLS) syndrome: Clinical, cytogenetic, and molecular characterization of 11 cases
Authors: Morleo Manuela , Pramparo Tiziano , Perone Lucia , Gregato Giuliana , Caignec Cedric Le , Mueller Robert F. , Ogata Tsutomu , Raas‐Rothschild Annick , de Blois Marie Christine , Wilson Louise C. , Zaidman Gerald , Zuffardi Orsetta , Ballabio Andrea , Franco Brunella 
Published: July 2005

AbstractThe microphthalmia with linear skin defects (MLS) syndrome (MIM 309801) is a severe and rare developmental disorder, which is inherited as an X‐linked dominant trait with male lethality. In the vast majority of patients, this syndrome is associated with terminal deletion of the Xp22.3 region. Thirty‐five cases have been described to date in the literature since the first description of the syndrome in the early 1990s. We now report on the clinical, cytogenetic, and molecular characterization of 11 patients, 7 of whom have not been described previously. Seven of these patients have chromosomal abnormalities of the short arm of the X‐chromosome, which were characterized and defined by fluorescence in situ hybridization (FISH) analysis. Intriguingly, one of the patients displays an interstitial Xp22.3 deletion, which to the best of our knowledge is the first reported for this condition. Finally we report on the identification and molecular characterization of four cases with clinical features of MLS but apparently normal karyotypes, verified by FISH analysis using genomic clones spanning the MLS minimal critical region, and with genome‐wide analysis using a 1 Mb resolution BAC microarray. These patients made it possible to undertake mutation screening of candidate genes and may prove critical for the identification of the gene responsible for this challenging and intriguing genetic disease. © 2005 Wiley‐Liss, Inc.
Characterization of a familial balanced rec(13) in a child with mild MR and his half‐sibling with two structurally rearranged chromosomes 13
Authors: Mehra S. , Christ L. , Jeng L. , Zinn A. B. , Schwartz S. 
Published: July 2005

AbstractIn this report, we describe a 7‐year‐old child with mild mental retardation, developmental delay, and learning disabilities. His karyotype contained a rearrangement of chromosome 13, which appeared to include a duplication of 13q31‐qter and a deletion of 13p12‐pter regions. The chromosomal origin of the additional material was confirmed by fluorescence in situ hybridization (FISH) using a whole chromosome painting probe specific for chromosome 13. Family studies showed that his mother carried a balanced inversion of chromosome 13 and that his half‐brother carried the balanced pericentric inversion of chromosome 13 from his mother as well as another structural rearrangement involving chromosome 13 presumably from his father. The findings from this study suggested that the proband's abnormal 13 resulted from an unbalanced crossing‐over between the normal and maternal inverted chromosome 13. © 2005 Wiley‐Liss, Inc.
Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups
Authors: Sarkar Kakali , Weinberg Clarice R. , Oddis Chester V. , Medsger Jr. Thomas A. , Plotz Paul H. , Reveille John D. , Arnett Frank C. , Targoff Ira N. , Genth Ekkehard , Love Lori A. , Miller Frederick W. 
Published: July 2005

AbstractObjectiveTo assess possible seasonal patterns in the onset of polymyositis (PM) and dermatomyositis (DM).MethodsThe study group comprised 503 patients who met the criteria for probable or definite PM or DM and for whom detailed data on the time of myositis onset were available. Statistical analyses were performed using a Poisson model that assessed associations of ethnicity, sex, autoantibody presence, and month of onset of muscle weakness.ResultsThere were no significant seasonal patterns of disease onset in myositis patients as a whole or in the total PM or DM populations. Significant seasonal associations were present, however, in the serologically defined groups. In the 131 patients with antisynthetase autoantibodies who were categorized as non‐black, myositis onset peaked in March–April (P = 0.03). Among the antisynthetase‐positive patients, the association was predominantly in those with PM (n = 85; P = 0.05) and in men (n = 51; P = 0.042). Patients with anti–signal recognition particle autoantibodies, however, did not have a significant seasonal onset, which is in contrast to previous findings. Patients without myositis‐specific autoantibodies showed a significant peak in summer, with myositis onset in June–July (n = 252; P = 0.03); this seasonal association was significant in women (n = 182; P = 0.005), whereas there was no seasonal pattern in men (P = 0.9).ConclusionThese findings, in conjunction with other data, suggest that diverse environmental agents, acting upon different immunogenetic backgrounds, result in distinct immune responses and clinical syndromes in the idiopathic inflammatory myopathies. Our results emphasize the importance of considering more homogeneous disease groups, based on clinicopathologic features, immune responses, ethnicity, and sex, when attempting to decipher the pathogeneses of autoimmune disorders.
New Odorless Method for the Corey—Kim and Swern Oxidations Utilizing Dodecyl Methyl Sulfide (Dod‐S‐Me).
Authors: Ohsugi Shin‐ichi , Nishide Kiyoharu , Oono Keiji , Okuyama Kazunori , Fudesaka Masato , Kodama Sumiaki , Node Manabu 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
NaBH4‐Mediated Facile Reduction of Esters of Baylis—Hillman Adducts: An Efficient Approach to Substituted Propane‐1,3‐diols.
Authors: Patra Arundhati , Batra Sanjay , Bhaduri Amiya P. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Thermal Stability of Lithium Nickel Oxide Derivatives. Part 1. LixNi1.02O2 and LixNi0.89Al0.16O2 (x = 0.50 and 0.30)
Authors: Guilmard M. , Croguennec L. , Denux D. , Delmas C. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
1‐[2‐(4‐Nitrophenoxy)acetyl]pyrrolidin‐2‐one: An Antiamnesic Agent
Authors: Thamotharan S. , Parthasarathi V. , Malik R. , Jindal D. P. , Piplani P. , Linden Anthony 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Step Stereocontrol of Three Contiguous Stereogenic Centers in Acyclic Systems: The Tuning Effect of an Additive in a Tandem Asymmetric Michael Addition and Meerwein—Ponndorf—Verley Reduction.
Authors: Nishide Kiyoharu , Ozeki Minoru , Kunishige Hideaki , Shigeta Yukihiro , Patra Pranab K. , Hagimoto Yuri , Node Manabu 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
(Z)‐1‐Aryl‐1‐haloalkenes as Intermediates in the Vilsmeier Haloformylation of Aryl Ketones.
Authors: Lilienkampf Annamaria , Johansson Mikael P. , Waehaelae Kristiina 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chemical Reactivity of 3‐Aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones Towards Nitrogen Nucleophiles. Part 1. One‐Pot Ring Conversion of 3‐Aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones into 4‐Amino‐2‐aryl‐5‐methyl‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones.
Authors: Kavali Jyothi R. , Kotresh O. , Badami Bharati V. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sequential Amination/Annulation/Aromatization Reaction of Carbonyl Compounds and Propargylamine: A New One‐Pot Approach to Functionalized Pyridines.
Authors: Abbiati Giorgio , Arcadi Antonio , Bianchi Gabriele , Di Giuseppe Sabrina , Marinelli Fabio , Rossi Elisabetta 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ruthenium‐Catalyzed Oxidative Coupling and Cyclization Between 2‐Aminobenzyl Alcohol and Secondary Alcohols Leading to Quinolines.
Authors: Cho Chan Sik , Kim Bok Tae , Choi Heung‐Jin , Kim Tae‐Jeong , Shim Sang Chul 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Sequential Pummerer—Diels—Alder Route for the Generation and Trapping of Furo[3,4‐c]pyridines: Synthesis of Heterocyclic Analogues of 1‐Arylnaphthalene Lignans.
Authors: Sarkar Tarun K. , Panda Niranjan , Basak Sankar 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Properties of N‐Alkyl‐6‐hydroxy‐5‐ (2,3,4,9‐tetrahydro‐1H‐β‐carbolin‐1‐yl)‐1H‐pyrimidine‐2,4‐diones and Their 2‐Thioanalogues.
Authors: Krasnov K. A. , Kartsev V. G. , Yurova M. N. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Design and Synthesis of Novel Chrysene‐Linked Pyrrolo[2,1‐c][1,4]‐benzodiazepine Hybrids as Potential DNA‐Binding Agents
Authors: Kamal Ahmed , Ramesh G. , Ramulu P. , Srinivas O. , Rehana Tasneem , Sheelu G. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Economic Preparation of 1,3‐Diphenyl‐1,3‐bis(diphenylphosphino)propane: A Versatile Chiral Diphosphine Ligand for Enantioselective Hydrogenations.
Authors: Dubrovina Natalia V. , Tararov Vitali I. , Monsees Axel , Kadyrov Renat , Fischer Christine , Boerner Armin 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Comparison of the Still—Gennari and Ando HWE‐Methodologies with α,β‐Unsaturated Aldehydes: Unexpected Results with Stannyl‐Substituted Systems.
Authors: Franci Xavier , Martina Sebastien L. X. , McGrady John E. , Webb Michael R. , Donald Craig , Taylor Richard J. K. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Evaluation of 4‐[(3‐Methyl‐3H‐imidazol‐4‐yl)‐(2‐phenylethynyl‐benzyloxy)methyl] ‐benzonitrile as Novel Farnesyltransferase Inhibitor.
Authors: Lin Nan‐Horng , Wang Le , Cohen Jerry , Gu Wen‐Zhen , Frost David , Zhang Haiying , Rosenberg Saul , Sham Hing 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Methodology of Intramolecular Hetero Diels—Alder Reaction with β‐Alkoxy‐Substituted Conjugated Nitroalkenes as Heterodienes: Stereoselective One‐Pot Synthesis of trans‐Fused Bicyclic γ‐Lactones.
Authors: Wada Eiji , Yoshinaga Masahiko 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 5‐(2‐Hydroxyethyl)‐1‐thia‐3,5,6,8‐tetraaza‐ and 1,3,5,6,8‐Pentaazaacenaphthylenes.
Authors: Tumkevicius S. , Sarakauskaite Z. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient and Direct Synthesis of Saccharidic 1,2‐Ethylidenes, Orthoesters, and Glycals from Peracetylated Sugars via in situ Generation of Glycosyl Iodides with I2/Et3SiH.
Authors: Adinolfi Matteo , Iadonisi Alfonso , Ravida Alessandra , Schiattarella Marialuisa 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of New Homo and Heterodimers of 2′,3′‐Dideoxyinosine (ddI) Using Ester Linkages
Authors: Ait Mohamed L. , Taourirte M. , Rochdi A. , Lazrek H. B. , Vasseur J. J. , Engels J. W. , Pannecouque C. , De Clercq E. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Deaza‐ and Deoxyadenosine Derivatives: Synthesis and Inhibition of Animal Viruses as Human Infection Models
Authors: Vittori Sauro , Salvatori Daniela , Volpini Rosaria , Vincenzetti Silvia , Vita Alberto , Taffi Sara , Costanzi Stefano , Lambertucci Catia , Cristalli Gloria 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiviral Evaluation of 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐C‐hydroxymethyl‐β‐D‐arabinofuranosyl Pyrimidine Nucleosides
Authors: Hassan Abdalla E. A. , Pai Balakrina S. , Lostia Stefania , Stuyver Lieven , Otto Michael J. , Schinazi Raymond F. , Watanabe Kyoichi A. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Structure and Lattice Dynamics of NH4IO3×2HIO3 Crystal as Derived from IR, Raman and 127I NQR Data.
Authors: Barabash A. , Baran J. , Gavrilko T. , Puchkovskaya G. , Ratajczak H. , Tarnavski Yu. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Homoallylic Chiral Tertiary Alcohols via Chelation‐Controlled Diastereoselective Nucleophilic Addition on α‐Alkoxyketones: Application for the Synthesis of the C1—C11 Subunit of 8‐epi‐Fostriecin.
Authors: Ramachandran P. Veeraraghavan , Liu Haipeng , Reddy M. Venkat Ram , Brown Herbert C. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Oxidative Reaction of 2‐Nitro‐1‐phenylpropane with Sodium Nitrite. A New Approach to Prepare 1‐Oximino‐1‐phenylacetone.
Authors: Ran Chongzhao , Yang Genjin , Wu Taizhi , Xie Meihua 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Pericyclic Reaction of Ketenes with Cascade Reaction Products of Pyridine N‐Oxides and Dipolarophiles. X‐Ray Structures of the Adducts and Formation Mechanism.
Authors: Oiso Shigeru , Eto Masashi , Yoshitake Yasuyuki , Harano Kazunobu 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Fragmentation of Carbohydrate Anomeric Alkoxyl Radicals. A New Synthesis of Chiral β‐Iodo Azides, Vinyl Azides, and 2H‐Azirines.
Authors: Alonso‐Cruz Carmen R. , Kennedy Alan R. , Rodriguez Maria S. , Suarez Ernesto 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Diastereoselective Synthesis of 2‐Substituted‐piperidin‐4‐ones as Convenient Precursors for an Asymmetric Approach to Carbacephams.
Authors: Barco Achille , Baricordi Nikla , Benetti Simonetta , Biondini Gisella , De Risi Carmela , Pollini Gian Piero 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ferroelectric Phase Transition in the Whitlockite‐Type Ca9Fe(PO4)7; Crystal Structure of the Paraelectric Phase at 923 K.
Authors: Lazoryak Bogdan I. , Morozov Vladimir A. , Belik Alexei A. , Stefanovich Sergey Yu. , Grebenev Vadim V. , Leonidov Il'ya A. , Mitberg Edward B. , Davydov Sergey A. , Lebedev Oleg I. , Van Tendeloo Gustaaf 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterization of an Organically‐Templated Zincophosphite: [C6H16N2] ×Zn3(HPO3)4.
Authors: Fu Wensheng , Shi Zhan , Li Guagnhua , Zhang Dong , Dong Wenjun , Chen Xiaobo , Feng Shouhua 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reduction of Carbonyl Compounds by Lanthanide Metal/2‐Propanol: In situ Generation of Samarium Isopropyloxide for Stereoselective Meerwein—Ponndorf—Verley Reduction.
Authors: Fukuzawa Shin‐ichi , Nakano Narihito , Saitoh Takahide 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Coupling Reactions of Hydralazine with Amino Acids and Their Adducts for Antihypertensive Activities.
Authors: Khattab Sherine N. , El Massry Abdel Moneim M. , El‐Faham Ayman , Bekhit Adnan A. , Amer Adel 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Studies on Reactions of 3‐Benzoyl‐4‐hydroxypyrido[3,2‐e]‐1,2‐thiazines with Primary Amines and N‐Methylhydrazine.
Authors: Malinka W. , Karczmarzyk Z. , Kaczmarz M. , Swiatek P. , Urbanczyk‐Lipkowska Z. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Magnetic Structure of NdMn2‐xFexGe2 (x = 0.1 and 0.15) Compounds
Authors: Szytula A. , Duraj R. , Hernandez‐Velasco J. , Penc B. , Venturini G. , Wawrzynska E. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Direct Catalytic Asymmetric Mannich‐Type Reaction of Hydroxyketone Using a Et2Zn/Linked‐BINOL Complex: Synthesis of Either anti‐ or syn‐β‐Amino Alcohols.
Authors: Matsunaga Shigeki , Yoshida Takamasa , Morimoto Hiroyuki , Kumagai Naoya , Shibasaki Masakatsu 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction of Bromo Dipoles with (Z)‐4‐(Arylmethylene)azol‐5‐ones. Substrate‐Controlled Synthesis of New Bromo‐Substituted Heterocyclic Spirans and Unusual N‐Benzoyl α‐Aminoacids.
Authors: Foti Francesco , Grassi Giovanni , Risitano Francesco , Rotondo Enrico , Zona Domenico 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Aryl 2,3‐Dibromopropyl Sulfones in S,N‐Tandem Heterocyclizations. New Synthesis of Benzimidazothiazolidines.
Authors: Shklyarenko A. A. , Yakovlev V. V. , Chistokletov V. N. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Zirconium(IV) Chloride Mediated Cyclodehydration of 1,2‐Diacylhydrazines: A Convenient Synthesis of 2,5‐Diaryl 1,3,4‐Oxadiazoles.
Authors: Sharma G. V. M. , Begum Asra , Rakesh Rakesh , Krishna Palakodety Radha 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Inhibition of Monoamine Oxidases by Coumarin‐3‐acyl Derivatives: Biological Activity and Computational Study.
Authors: Chimenti Franco , Secci Daniela , Bolasco Adriana , Chimenti Paola , Granese Arianna , Befani Olivia , Turini Paola , Alcaro Stefano , Ortuso Francesco 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Direct Synthesis of 4‐Arylpiperidines via Palladium/Copper(I)‐Cocatalyzed Negishi Coupling of a 4‐Piperidylzinc Iodide with Aromatic Halides and Triflates.
Authors: Corley Edward G. , Conrad Karen , Murry Jerry A. , Savarin Cecile , Holko Justin , Boice Genevieve 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Selective Synthesis of 2‐Substituted‐5‐hydroxy‐6‐oxo‐1,6‐dihydropyrimidine‐4‐carboxylic Acid Derivatives Using a Novel Protected Dihydroxyfumarate.
Authors: Dreher Spencer D. , Ikemoto Norihiro , Gresham Venita , Liu Jinchu , Dormer Peter G. , Balsells Jaume , Mathre David , Novak Thomas J. , Armstrong Joseph D. III 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Expeditious Entry to Carbohydrate Derived Enynes and Ene‐Diynes via Sonogashira Coupling of Halo‐exo‐Glycals.
Authors: Gomez Ana M. , Pedregosa Ana , Barrio Aitor , Valverde Serafin , Lopez J. Cristobal 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of 10‐Oxo, 10α‐Hydroxy, and 10β‐Hydroxy Derivatives of a Potent ϰ‐Opioid Receptor Agonist, TRK‐820.
Authors: Horikiri Hiromasa , Hirano Noriyuki , Tanaka Yoichiro , Oishi Junji , Hatakeyama Hitoshi , Kawamura Kuniaki , Nagase Hiroshi 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The First Example of the Stereoselective Synthesis of 7β‐Carbamoyl‐4,5α‐epoxymorphinan via a Novel and Reactive γ‐Lactone.
Authors: Fujii Hideaki , Hirano Noriyuki , Uchiro Hiromi , Kawamura Kuniaki , Nagase Hiroshi 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Efficient Synthesis of Resorcinylic Macrolides via Ynolides: Establishment of Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent Based on Hsp90 as the Target.
Authors: Yang Zhi‐Qiang , Geng Xudong , Solit David , Pratilas Christine A. , Rosen Neal , Danishefsky Samuel J. 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, NMR Spectra and X‐Ray Data of Chloro and Dichloro Derivatives of 3‐Hydroxy‐2‐phenylquinolin‐4(1H)‐ones and Their Cytostatic Activity.
Authors: Hradil Pavel , Krejci Petr , Hlavac Jan , Wiedermannova Iveta , Lycka Antonin , Bertolasi Valerio 
Published: July 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nerve growth factor sensitivity is broadly distributed among myenteric neurons of the rat colon
Authors: Lin Agueda , Lourenssen Sandra , Stanzel Roger D.P. , Blennerhassett Michael G. 
Published: July 2005

AbstractNerve growth factor (NGF) acts on the two‐receptor system of trkA and p75 to mediate neuroprotection and influence phenotype and function in the peripheral nervous system, but the effects of NGF on the enteric nervous system (ENS) are virtually unknown. To establish a basis for enteric responsiveness to NGF, we studied the presence and distribution of NGF‐sensitive receptors in the myenteric neurons of the normal rat colon and examined their activation via trkA phosphorylation. Fluorescent immunocytochemistry on wholemounts showed that the two NGF receptors were abundantly present in the ENS, with 71% of all neurons positive for trkA and 78% for p75. More thanr 60% of the myenteric neurons expressed both receptors, and exogenous application of NGF resulted in trkA phosphorylation, evidence for high NGF sensitivity within the ENS. trkA was co‐expressed with choline acetyltransferase (61% of trkA‐positive neurons), neuronal nitric oxide synthase (22%), or calbindin (10%), suggesting widespread potential for NGF action. We conclude that functional receptors for NGF are widely distributed among the diverse enteric phenotypes and argue for a novel NGF‐mediated regulatory system within the ENS. J. Comp. Neurol. 490:194–206, 2005. © 2005 Wiley‐Liss, Inc.