bluuebunny/crossref_metadata_2025_split huggingface dataset:
Road‐traffic‐related air pollution contributes to skin barrier alteration and growth defect of sensory neurons
Authors: Le Gall‐Lanotto Christelle , Verdin Anthony , Cazier Fabrice , Bataille‐Savattier Adeline , Guéré Christelle , Dorr Marie M. , Fluhr Joachim W. , Courcot Dominique , Vié Katell , Misery Laurent 
Published: January 2024

AbstractThe effects of air pollution on health are gaining increasing research interest with limited data on skin alterations available. It was suggested that air pollution is a trigger factor for sensitive skin (SS). However, this data was based on surveys with a lack of experimental data. SS is related to altered skin nerve endings and cutaneous neurogenic inflammation. TTe present study was to assess the in vitro effect of particulate matter (PM) on epidermis and nerve ending homeostasis. PM samples were collected according to a validated protocol. Reconstructed human epidermis (RHE, Episkin®) was exposed to PM and subsequently the supernatants were transferred to a culture of PC12 cells differentiated into sensory neurons (SN). Cell viability, axonal growth and neuropeptide‐release were measured. The modulation of the expression of different inflammatory, keratinocytes differentiation and neurites growth markers was assessed. PM samples contained a high proportion of particles with a size below 1 μm and a complex chemical composition. Transcriptomic and immunohistochemical analyses revealed that PM altered keratinocytes terminal differentiation and induced an inflammatory response. While viability and functionality of the SN were not modified, their outgrowth was significantly decreased after incubation with PM‐exposed Episkin® supernatants. This was closely related to the modification of nerve growth factor/semaphorin 3A balance. This study showed that air pollutants have negative effects on keratinocytes and sensory nerve endings including inflammatory responses. These effects are probably involved in the SS pathophysiology and might be involved in inflammatory skin disorders.
Can financial uncertainty forecast aggregate stock market returns?
Authors: Henry Ólan , Kerestecioglu Semih , Pybis Sam 
Published: January 2024

AbstractWe investigate the role of financial uncertainty in forecasting aggregate stock market returns. Our results suggest that financial uncertainty, along with its change, are more powerful predictors of excess US monthly stock market returns than 14 macroeconomic predictors commonly used in the literature. Financial uncertainty is shown to outperform short interest, which has been suggested to be the strongest known predictor of the equity risk premium. These results persist using robust econometric methods in‐sample, and when forecasting out‐of‐sample.
Bullous pemphigoid and diabetes mellitus: a systematic review and meta‐analysis
Authors: Jiirasutat Nuttapatch , Pongchareon Padcha , Weschawalit Sinee 
Published: January 2024

AbstractWe aimed to systematically review and meta‐analyze the association between diabetes mellitus (DM) and bullous pemphigoid (BP). Bullous pemphigoid (BP) is a prevalent autoimmune subepidermal blistering disease. Comorbid health conditions like neurological diseases and malignancies have been associated with BP. Growing evidence suggests that type 2 diabetes mellitus (T2DM) may increase the risk of developing BP. This review aims to synthesize this evidence. A systematic literature review was performed using Medline, PubMed, and Scopus in March 2022. Studies exploring the association between BP and DM were included. Data were extracted, and quality was assessed using the Newcastle–Ottawa scale. Meta‐analysis was conducted to identify the odds ratio (OR) and 95% confidence intervals (CI) of the association. Seventeen studies were included, most being case–control studies from Europe and Asia. The pooled OR was 2.06 (95% CI: 1.61–2.62), suggesting a significant association between DM and BP. However, strong heterogeneity (I2 = 88%) was observed. Evidence consolidates a significant relationship between DM and BP, potentially due to alterations in the immune system and skin properties caused by diabetes. Strengths of this review include a comprehensive search, rigorous methodology, large sample size, and heterogeneity evaluation. However, varying study quality, potential publication bias, and unaccounted confounding factors present limitations. There is a potential link between T2DM and an increased risk of BP. Further studies are required to understand this association and the underlying mechanisms.
Macroscopic tumor dimension, sentinel lymph node outcome, and survival analysis among cutaneous melanoma
Authors: Asato Marcel A. , Moraes‐Neto Francisco A. , Moraes Marcelo Padovani de Toledo , Ocanha‐Xavier Juliana P. , Alencar Marques Mariangela Esther , Xavier‐Junior Jose Candido C. 
Published: January 2024

AbstractBackgroundCutaneous melanoma is characterized by a high risk of metastasis to distant organs and a substantial mortality rate. For planning treatment and assessing outcomes, the Breslow micrometric measurement is critical. The tumor macroscopic dimension is not considered a prognostic parameter in cutaneous melanoma, although there are studies showing that tumor size is an independent prognostic factor for melanoma‐specific survival. Therefore, this study aimed to evaluate the macroscopic dimension of melanoma and other known prognostic factors (i.e., Breslow index, mitoses, regression, and ulceration) as predictors of sentinel lymph node outcome and survival outcome.MethodsWe performed a retrospective cross‐sectional study of 227 melanoma lesions subjected to sentinel lymph node biopsy at two Brazilian referral centers.ResultsOn univariate analysis, there was a statistically significant correlation between the largest macroscopic tumor dimension and the sentinel lymph node result (P = 0.001); however, on multivariate analysis considering all evaluated parameters, there was no significant difference between the sentinel lymph node result and the tumor macroscopic dimension (P = 0.2689). Regarding melanoma‐specific survival, the macroscopic dimension showed no significant correlation (P = 0.4632) in contrast to Breslow's dimension (P < 0.0001).ConclusionThe Breslow thickness was the only significant factor related to both the sentinel lymph node outcome and melanoma specific survival among the evaluated variables.
Defatted tigernut flour as a novel substitute for wheat flour: impact on physicochemical and rheological properties during frozen dough storage
Authors: Wu Zhong‐Wei , Cui Xin‐Yu , Wei Yang‐Yang , Liu Hua‐Min , Cai Xiao‐Shuang , Ma Yu‐Xiang , Wang Xue‐De 
Published: January 2024

SummaryThis study analysed the impact of adding different amounts (5–25%) of defatted tigernut flour (DTF) to frozen wheat dough at different freezing periods. The chemical composition and freeze–thaw stability of the composite flour, as well as the physicochemical properties (e.g., textural, tensile, and rheological properties) of the dough after being frozen, were assessed. It was found that the addition of DTF enhanced the nutritional value of the dough and improved quality characteristics such as texture and tensile properties of the dough after it had been frozen and thawed. With increasing DTF, the content of dietary fibre (8.69–9.63%) and ash (0.54–1.05%) increased significantly, but the content of starch (58.56–54.96%) and protein (11.03–10.35%) decreased as compared to that of wheat flour alone. The thermal and freeze–thaw stability of composite flour was greatly improved with increasing amounts of DTF, and the retrogradation of the dough was delayed. DTF (5–15%) proportionately delayed deterioration of springiness and retarded hardening of the frozen dough. In addition, the extensibility of the frozen dough was significantly increased by adding 10–25% DTF. The results suggest that DTF has the potential to positively influence the quality of frozen wheat dough, while at the same time increasing the high‐value utilisation of tigernut.
Multiple risk factors for unplanned readmissions within 1 month of hospital discharge in acute care hospitals in Japan
Authors: Tomita Masako , Murata Kanako , Suzuki Hiroko , Osaki Chieko , Matuki Eri , Komatuzaki Kiiko , Ishihara Yukie , Yoshihara Shoko , Sakai Shima 
Published: January 2024

AbstractAimThe aim of this study is to analyse the risk factors for unplanned readmissions within 1 month after hospital discharge to develop a seamless support system from discharge to home care.BackgroundWith shorter hospital stay lengths, understanding the characteristics of patients with multiple risk factors is important to prevent rehospitalization.DesignThis is a single‐centre retrospective descriptive study.MethodsLogistic regression and decision tree analyses were performed using eight items from the records of 3117 patients discharged from a university hospital between April–September 2017 as risk factors.ResultsUnplanned readmission risk was significantly associated with emergency hospitalization (odds ratio [OR]: 3.12, 95% confidence interval [CI]: 2.04–4.77), malignancy (OR: 2.16, 95% CI: 1.44–3.24), non‐surgical admission (OR: 1.76, 95% CI: 1.07–2.88), hospital stay of ≥ 15 days (OR: 1.66, 95% CI: 1.14–2.43) and decline in activities of daily living owing to hospitalization (OR: 1.68, 95% CI: 1.06–2.64). The highest risk combinations for rehospitalization were as follows: emergency hospitalization and malignancy; emergency admission, non‐malignancy and a hospital stay of ≥15 days; and scheduled hospitalization, no surgery and a hospital stay of ≥15 days.ConclusionsPatients with multiple risks for unplanned readmission should be accurately screened and provided with optimal home care.
Liposomal delivery of self‐peptide and calcitriol as tolerogenic immunotherapy in rheumatoid arthritis: an exploration using sensory science
Authors: Hee Jia Yi , Cai Benjamin , Thomas Ranjeny 
Published: January 2024

AbstractImmunology research holds significant potential for enhanced inclusivity at the beginning of the science literacy journey, but persistent challenges stem from limited awareness that improvement is needed in this field. At the 2023 Monash Sensory Science Exhibition, we had the opportunity to present several tactile posters, using simple materials, for visually impaired participants to showcase our research on the pathogenesis of rheumatoid arthritis as a result of immune tolerance breakdown and liposome‐based tolerogenic immunotherapy. The posters stimulated lively discussions about autoimmune arthritic diseases and our research. With consideration of the diversity of the participants, the efforts of scientists in promoting science literacy for the community can promote a more inclusive environment and engage and inspire a broader audience.
Comparing apples to manzanas and oranges to naranjas: A new measure of English‐Spanish vocabulary for dual language learners
Authors: Tamis‐LeMonda Catherine S. , Kachergis George , Masek Lillian R. , Gonzalez Sandy L. , Soska Kasey C. , Herzberg Orit , Xu Melody , Adolph Karen E. , Gilmore Rick O. , Bornstein Marc H. , Casasola Marianella , Fausey Caitlin M. , Frank Michael C. , Goldin‐Meadow Susan , Gros‐Louis Julie , Hirsh‐Pasek Kathy , Iverson Jana , Lew‐Williams Casey , MacWhinney Brian , Marchman Virginia A. , Naigles Letitia , Namy Laura , Perry Lynn K. , Rowe Meredith , Sheya Adam , Soderstrom Melanie , Song Lulu , Walle Eric , Warlaumont Anne S. , Yoshida Hanako , Yu Chen , Yurovsky Dan 
Published: January 2024

AbstractThe valid assessment of vocabulary development in dual‐language‐learning infants is critical to developmental science. We developed the Dual Language Learners English‐Spanish (DLL‐ES) Inventories to measure vocabularies of U.S. English‐Spanish DLLs. The inventories provide translation equivalents for all Spanish and English items on Communicative Development Inventory (CDI) short forms; extended inventories based on CDI long forms; and Spanish language‐variety options. Item‐Response Theory analyses applied to Wordbank and Web‐CDI data (n = 2603, 12–18 months; n = 6722, 16–36 months; half female; 1% Asian, 3% Black, 2% Hispanic, 30% White, 64% unknown) showed near‐perfect associations between DLL‐ES and CDI long‐form scores. Interviews with 10 Hispanic mothers of 18‐ to 24‐month‐olds (2 White, 1 Black, 7 multi‐racial; 6 female) provide a proof of concept for the value of the DLL‐ES for assessing the vocabularies of DLLs.
Collaborative leadership and productive work performance: The mediating role of nurses' innovative behavior
Authors: Abdelwahab Ibrahim El‐Sayed Ahmed , Shaheen Rabab Saleh , Farghaly Abdelaliem Sally Mohammed 
Published: January 2024

AbstractAimThis study aims to explore the relationship between collaborative leadership and nurses' productive work performance as well as the mediating role of nurses' innovative behavior in this relationship.BackgroundCollaborative leadership is an imperative necessity in the contemporary turbulent healthcare environment as it provides a collaborative atmosphere where innovative behavior and productive performance of nurses are fostered, hence moving healthcare organizations toward competitiveness and sustainability.MethodA cross‐sectional descriptive correlational exploratory research design was used to conduct the study. Data were collected from 550 nurses recruited from three large university hospitals in Alexandria, Egypt, using three instruments, namely, interprofessional collaborative leadership in healthcare teams scale, productive work performance questionnaire, and innovative behavior inventory. The instruments of the study are Likert‐type questionnaires through which nurses' perspectives regarding study variables were investigated. We used descriptive statistics, inferential statistics as well as structured equation modeling (SEM).ResultsSEM revealed that collaborative leadership accounted for 83% of the variance of individual productive work performance and 77% of the variance of nurses’ innovative behavior. Moreover, nurses' innovative behavior partially mediates the relationship between collaborative leadership and their productive work performance.ConclusionCollaborative leadership practices are powerful strategies to enhance the innovative behavior of nurses and sustain their productive work performance.Implications for nursing and health policyFostering a collaborative atmosphere in workplace is mandatory for nurses' innovativeness. Replacing hierarchal leadership styles with collaborative ones is a promising strategy to enhance the productive performance of nurses. Healthcare managers and leaders could cultivate an interprofessional collaborative culture in the workplace in order to sustain productivity and eradicate counterproductive work behaviors among healthcare providers.
Comparative evaluation of the clinical success of 3D‐printed space maintainers and band–loop space maintainers
Authors: Cengiz Ayşe , Karayilmaz Hüseyin 
Published: January 2024

AbstractBackgroundExploring the integration of 3D‐printing technology in space maintainer (SM) manufacturing could offer innovative solutions and insights for enhancing SMs.AimTo compare the clinical success, retention, and periodontal effect of traditional band–loop (TBL) SMs with 3D‐printed SMs.DesignSeventy children (mean age: 6.99 ± 1.18) were divided into two groups. Laser sintering (LS) group (n = 34): Patients were scanned with an intraoral scanner. SMs were produced with LS 3D‐printing method from a titanium‐based metal powder. T group (n = 36): Impressions were taken with alginate. SMs were produced by adjusting the bands and soldering the wires on the model. The retention and effects on oral hygiene of the SMs were evaluated at the sixth month. Preference for impression technique was assessed by a five‐question survey.ResultsThirty‐eight percent of T SMs and 66% of LS SMs failed (p = .007). The mean survival time was significantly higher in the T group (p = .035). No difference was found between the initial and control full‐mouth Gingival Index (GI) and Plaque Index (PI) values of the two groups. Both groups had increased GI/PI values in abutment teeth. Patients in the LS group interpreted their impression experience more positively.ConclusionIt is important to provide oral hygiene education before applying fixed SMs and utilize more digital workflow in paediatric dentistry.
Exact and heuristic solutions for the prize‐collecting geometric enclosure problem
Authors: Ramos Natanael , Cano Rafael G. , de Rezende Pedro J. , de Souza Cid C. 
Published: January 2024

AbstractIn the prize‐collecting geometric enclosure problem (PCGEP), a set of points in the plane is given, each with an associated benefit. The goal is to find a simple polygon with vertices in that maximizes the sum of the benefits of the points of enclosed by minus the perimeter of multiplied by a given nonnegative cost. The PCGEP is NP‐complete and has applications to land surveying for exploration or preservation of natural resources. In this paper, we develop the first heuristic, called PCGEP‐GR, for the PCGEP and revisit a previously proposed integer linear programming (ILP) model to solve it to optimality. We conducted a comprehensive experimental study of that heuristic and an exact algorithm based on the ILP model. We show that a new set of constraints, together with the previous set, is necessary to guarantee the correctness of the ILP model and introduce preprocessing strategies that allow us to prove optimality 40% faster on average. The proposed heuristic is able to reach the optimum in 32% of our benchmark instances and, for those with unknown optima, PCGEP‐GR was found better than or at least as good solutions as the ones obtained by the cplex ILP solver in 54% of the cases. Notwithstanding these positive results, the design of effective heuristics for the PCGEP proved to be very challenging, which also led us to obtain a result that provides the theoretical foundation for future advances in the study of this problem.
Epitope screening and vaccine molecule design of PRRSV GP3 and GP5 protein based on immunoinformatics
Authors: Liu Dongyu , Chen Yaping 
Published: January 2024

AbstractPorcine reproductive and respiratory syndrome (PRRS) is a respiratory disease in pigs that causes severe economic losses. Currently, live PRRSV vaccines are commonly used but fail to prevent PRRS outbreaks and reinfection. Inactivated PRRSV vaccines have poor immunogenicity, making PRRSV a significant threat to swine health globally. Therefore, there is an urgent need to develop an effective PRRSV vaccine. This study used immunoinformatics to predict, screen, design and construct a candidate vaccine that fused B‐cell epitopes, CTL‐ and HTL‐dominant protective epitopes of PRRSV strain's GP3 and GP5 proteins. The study identified 12 B‐cell epitopes, 6 CTL epitopes and 5 HTL epitopes of GP3 and GP5 proteins. The candidate vaccine was constructed with 50S ribosomal protein L7/L1 molecular adjuvant, which has antigenicity, solubility, stability, non‐allergenicity and a high affinity for its target receptor, TLR‐3. The C‐ImmSim immunostimulation results showed significant increases in cellular and humoral responses (B cells and T cells) and production of TGF‐β, IL‐2, IL‐10, IFN‐γ and IL‐12. The constructed vaccine was stable and immunogenic, and it can effectively induce strong T‐cell and B‐cell immune responses against PRRSV. Therefore, it is a promising candidate vaccine for controlling and preventing PRRSV outbreaks.
Substance use outcomes from the Child/Adolescent Anxiety Multimodal Extended Long‐term Study (CAMELS)
Authors: Rabner Jonathan , Olino Thomas M. , Albano Anne Marie , Keeton Courtney P. , Sakolsky Dara , Birmaher Boris , Piacentini John , Peris Tara S. , Compton Scott N. , Gosch Elizabeth , Ginsburg Golda S. , Pinney Elizabeth L. , Kendall Philip C. 
Published: January 2024

BackgroundSubstance use problems and anxiety disorders are both highly prevalent and frequently cooccur in youth. The present study examined the benefits of successful anxiety treatment at 3–12 years after treatment completion on substance use outcomes (i.e. diagnoses and lifetime expected use).MethodsThe sample was from the Child/Adolescent Anxiety Multimodal Extended Long‐term Study (CAMELS), a naturalistic follow‐up study to the Child/Adolescent Anxiety Multimodal Study (CAMS) which randomized youth to cognitive behavioral therapy (CBT; Coping cat), medication (sertraline), their combination, or pill placebo. The first CAMELS visit occurred an average of 6.5 years following CAMS randomization. Participants were 319 youth (65.4% of the CAMS sample), aged 7–17 years at CAMS baseline assessment with a mean age of 17.6 years (range: 11–26 years) at the time of the first CAMELS follow‐up. Substance use outcomes included diagnoses as well as lifetime substance use (i.e. alcohol and tobacco use).ResultsEleven of 319 (3.4%) CAMELS participants were diagnosed with a substance use disorder at the initial follow‐up visit. When compared to the population lifetime rate of 11.4%, the rate of diagnoses in the posttreated sample was significantly lower. Additionally, rates of lifetime alcohol use were lower than population rates at the initial and final follow‐up visits. Rates of lifetime tobacco use were similarly lower than lifetime population rates at the initial visit (driven by significantly lower rates in the CBT treatment condition), but higher by the final visit. Furthermore, treatment remission (but not treatment response) was associated with a lower rate of substance use diagnoses at the initial follow‐up visit, although rates of lifetime alcohol and tobacco use did not differ by treatment outcome.ConclusionsAnxiety treatments confer a beneficial impact on problematic substance use (i.e. diagnoses) as well as on expected substance use (i.e. alcohol and tobacco use) for on average, a period of 6.5 years.
“They don't let us speak”: Gender, collegiality, and interruptions in deliberations in the Brazilian Supreme Court
Authors: Arguelhes Diego Werneck , Cesario Alvim Juliana , Nogueira Rafaela , Wang Henrique 
Published: January 2024

AbstractIn this paper, we examine a database containing court rulings and debates (acórdãos) of the Brazilian Supreme Court (“STF”) spanning from 1999 to 2018. Our objective is to analyze the relationship between gender and how judges behave when interacting with each other. Specifically, we investigate whether female judges are more likely to be interrupted by their colleagues during oral debates. Our data are built on real‐time public interactions between the judges, as recorded in the Court's transcripts. The results show that female STF judges are interrupted more often than their male counterparts. While male judges display no specific effects, all three female judges in our data display a very significant and positive probability of being interrupted, as compared to their male colleagues participating in the same deliberations. These results show that, even in institutions designed to protect rights of political minorities, including women, gender dynamics, stereotypes and hierarchies can affect the functioning of courts in visible ways, with potential impacts on the rest of the judiciary and the legal profession. They also suggest that merely increasing the number of female judges, without addressing underlying gender dynamics and procedural rules in the judicial decision‐making process, is insufficient to tackle the disadvantages women face within those institutions.