bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of rare bleeding disorders in adolescents with heavy menstrual bleeding
Authors: Sharma Ruchika , Johnson Victoria , Pan Amy , Sellers Austin , Betensky Marisol , Goldenberg Neil , Flood Veronica H. 
Published: February 2024

AbstractIntroductionThere are a significant number of patients with mucocutaneous bleeding, specifically heavy menstrual bleeding (HMB), who do not have a diagnosed bleeding disorder. These patients receive nontargeted interventions and may have suboptimal treatments. Functional assays, particularly for fibrinolytic and rare platelet function defects, are not robust and not readily available.AimWe aimed to prospectively evaluate the prevalence of genetic defects associated with rare bleeding disorders and describe alterations of coagulation and fibrinolysis in a cohort of adolescents with HMB.MethodsWe performed a prospective observational cohort study of patients with HMB and unexplained bleeding. The study utilized a next generation sequencing panel and investigational global assays of coagulation and fibrinolysis. Additionally, specific functional assays were performed to help characterize novel variants that were identified.ResultsIn 10 of the 17 patients (∼59%), genetic variants were identified on molecular testing. Thrombin generation by calibrated thromboelastography was not significantly altered in this patient population. The clot formation and lysis assay showed a trend towards increased fibrinolysis with rapid phase of decline in 23% of the patients. Further corresponding functional assays and study population are described.ConclusionOur study describes a unique correlative model in a homogenous cohort of patients with HMB and unexplained bleeding which may inform future diagnostic algorithms, genotype–phenotype correlations as well as aid in specific targeted treatment approaches. Larger future studies may inform risk stratification of patients and improve health related outcomes in patients with HMB.
Hydration properties of magnesium phosphate cement paste mixed with metakaolin and silica fume
Authors: Liu Runqing , Wang Wei , Yang Yuanquan 
Published: February 2024

AbstractMagnesium phosphate cement (MPC) exhibits a faster setting time and higher early strength, making it suitable for crack repair. However, its application in civil engineering is hindered by its fast initial hydration rate and poor water resistance. To address these limitations, metakaolin (MK) and silica fume (SF) were utilized to enhance the properties of MPC. The effects of MK and SF on the setting time, compressive strength, water resistance, hydration process, and microstructure of MPC were investigated. The results demonstrate that both MK and SF significantly prolong the setting time of MPC and improve its water resistance. The main hydration products of MPC, after incorporating MK and SF, are k‐struvite (MgKPO4·6H2O) and unreacted MgO. The presence of MgSiO3 and AlPO4 also contributes to the enhancement of compressive strength and water resistance. The incorporation of MK and SF actively participates in the hydration reaction of the MPC system. Furthermore, MgSiO3 and AlPO4 intertwine with MKP, resulting in a denser internal structure of the cured MPC, thereby improving its water resistance.
Do hospitals attaining a public recognition for treating nurses fairly deliver better‐quality health care? Evidence from cross‐sectional analysis of California hospitals
Authors: Shen Hsiu‐Chu , Li Chien‐Ching , Yeh Shu‐Chuan Jennifer 
Published: February 2024

AbstractAimThis study explored whether hospitals that allocate greater resources to their nursing staff provide better healthcare services than those that invest less in their nursing personnel.DesignCross‐sectional logistic and tobit analyses.MethodsWe examined a sample of 314 California hospitals in 2017. We obtained a hospital's public recognition for treating nurses fairly between 2015 and 2017 from Nurse.org, the largest online community of nurses. We derived a hospital's healthcare quality in 2018 from the 2019–2020 Best Hospitals rankings released by U.S. News, a well‐known media company publishing independent healthcare assessments periodically.ResultsOur results showed that a nurse‐friendly workplace was a crucial determinant of its overall healthcare quality.Conclusion and implicationsHealthcare administrators keen to enhance the quality of healthcare services should consider creating nurse‐friendly workplaces. Furthermore, their evaluation of nurses' contributions to overall healthcare quality should not solely depend on the nurse‐assessed quality of care, but rather comprise not only broad aspects of patient outcomes in primary care but also patient experiences, care‐related factors and expert opinions.Patient or public contributionOur study helped address the overwhelmed healthcare system, whose long‐running shortage of nurses has been exacerbated by the COVID‐19 pandemic. Our work suggested that a hospital's investment in a nurse‐friendly workplace can enhance its acquisition, retention and devotion of the nursing staff. This, in turn, can have profound impacts on its overall healthcare quality.What already is knownExisting empirical evidence on the relation between nurse‐friendly workplace and healthcare quality is limited and inconclusive.What this paper addsWe documented evidence that the quality of healthcare services provided by hospitals varies with their treatment of nursing staff.Implications for practice/policyOur results provided insights into key policies that have the potential to improve healthcare quality.
Plasminogen activator inhibitor‐1 serum levels in frontotemporal lobar degeneration
Authors: Angelucci Francesco , Veverova Katerina , Katonová Alžbeta , Vyhnalek Martin , Hort Jakub 
Published: February 2024

AbstractPlasminogen activator inhibitor‐1 (PAI‐1) impedes brain plasmin synthesis. Reduced plasmin activity facilitates cumulation of amyloid beta (Aβ) in Alzheimer's disease (AD). Since plasmin also regulates the synaptic activity, it is possible that altered PAI‐1 is present in other neurodegenerative disorders. We investigated whether PAI‐1 and its counter‐regulatory tissue plasminogen activator (tPA) are altered in serum of patients with dementia due to frontotemporal lobar degeneration (FTLD). Thirty five FTLD patients (21 in mild cognitive impairment stage (MCI) and 14 in dementia stage) and 10 cognitively healthy controls were recruited. Serum tPA and PAI‐1 protein levels were measured by anova. Correlation between biochemical and demographic data were explored by measuring Pearson correlation coefficient. Serum PAI‐1 levels were elevated in the FTLD dementia group as compared to FTLD MCI and controls. tPA serum levels and PAI‐1/tPA ratio did not significantly differ among groups. There was a negative correlation between PAI‐1 serum levels and disease severity measured by MMSE score. No correlations of tPA serum levels and PAI‐1/tPA ratio with MMSE were found. Increased PAI‐1 serum levels may serve as a marker of dementia in FTLD, suggesting that, besides Aβ pathway, the plasmin system may affect cognition through synaptic activity.
Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review
Authors: Cespiati Annalisa , Coelho Rodrigues Inês , Santos Inês , Policarpo Sara , Carvalhana Sofia , Fracanzani Anna Ludovica , Cortez‐Pinto Helena 
Published: February 2024

AbstractBackground and AimsThe beneficial effect of Hepatitis C virus (HCV) eradication by direct antiviral agents (DAAs) on liver fibrosis is well defined. Despite this, the impact of viral eradication in both hepatic and extra‐hepatic metabolic features is underreached. This systematic review aimed to synthesize the evidence on the impact of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, glucidic impairment, dyslipidaemia, and weight gain.MethodsA systematic search of the existing literature (up to December 2022) identified 97 original studies that fulfilled the inclusion criteria.ResultsWhereas total cholesterol and low‐density lipoprotein (LDL) seem to increase after viral eradication, the cardiovascular damage expressed as carotid plaques and intima‐media thickness seems to improve. Otherwise, the effect on liver steatosis, glucidic homeostasis, and weight seems to be strictly dependent on the presence of baseline metabolic disorders.ConclusionDespite high heterogeneity and relatively short follow‐up of included studies, we can conclude that the presence of metabolic risk factors should be strictly evaluated due to their impact on liver steatosis, glucidic and lipid homeostasis, and on weight gain to better identify patients at risk of liver disease progression despite the virus eradication.
A narrative inquiry into non‐Indigenous medical educators and leaders participation in reconciliatory work
Authors: Burm Sarah , Dean Libby , Alcock Danielle , LaDonna Kori A. , Watling Christopher J. , Bishop Lisa 
Published: February 2024

AbstractIntroductionGlobally, medical schools are operationalising policies and programming to address Indigenous health inequities. Although progress has been made, challenges persist. In Canada, where this research is conducted, Indigenous representation within medical schools remains low, leaving a small number of Indigenous advocates leading unprecedented levels of equity‐related work, often with insufficient resources. The change needed within medical education cannot fall solely on the shoulders of Indigenous Peoples; non‐Indigenous Peoples must also be involved. This work aims to better understand the pathways of those engaged in this work, with careful consideration given to the facilitators and barriers to ongoing engagement.MethodsData collection and analysis were informed by narrative inquiry, a methodology that relies on storytelling to uncover nuance and prompt reflection. In this paper, we focus on interview data collected from Canadian non‐Indigenous medical educators and leaders (n = 10). Participants represented different career stages, (early to late career) and occupied a mix of clinical, administrative and education roles.ResultsAlthough each participant's entry into reconciliatory work was unique, we identified common drivers actuating their engagement. Oftentimes their participation was tied to administrative work or propelled by experiences within their roles that forced them to confront the systemic inequalities borne by Indigenous Peoples in both academic and healthcare settings. Some admitted to struggling with understanding their appropriate role in Indigenous reconciliation; their participation often proceeded without firm support.ConclusionMedical schools have an obligation to ensure their faculty, including non‐Indigenous Peoples, are equipped to fulfil social accountability mandates regarding Indigenous health. Our findings generate a better understanding of the tensions inherent in this equity work. We urge others to reflect on their role in Indigenous reconciliation, or else medical schools risk generating a false sense of individual and institutional progress.
Functional connectivity characteristics of the brain network involved in prickle perception of single fiber stimulation
Authors: Wang Qicai , Mei Yonghao , Tao Yuan , Ao Jiayu , Zhang Zhongwei , Yuan Jie , Hong Xinghua , Zeng Fangmeng , Jin Zimin 
Published: February 2024

AbstractBackgroundThe complex network connections, information transmission and organization play key roles in brain cognition on sensory stimulation. Previous studies showed that several brain regions of somatosensory, motor, emotional, cognitive, etc. are linked to fabric‐evoked prickle. But the functional connectivity characteristics of the brain network involved in prickle perception is still unclear.Materials and MethodsIn the present study, resting state fMRI (functional magnetic resonance imaging) with functional connectivity analysis was adopted to build the initial brain functional network, and task fMRI with psychophysiological interaction analysis was employed to investigate modulation features of prickling task to functional connections in the brain network.ResultsThe results showed that, in resting state, six groups or sub‐networks can be identified in the prickle network, and when the subjects performed the prickling task, functional connectivity strength between some seed regions (e.g., somatosensory regions and precuneus, emotional regions and the prefrontal cortex, etc.) in the network increased.ConclusionCombining resting‐state fMRI with task fMRI is a feasible and promising method to study functional connectivity characteristics of the brain network involved in prickle perception. It is inferred that the “itch” ingredient of prickle sensation was transmitted from somatosensory cortices to precuneus, and emotional attribute (e.g., pain) from somatosensory cortices to the prefrontal cortex and at last to emotional regions.
Farmers' perception of soil health: The use of quality data and its implication for farm management
Authors: Falcão Raquel N. R. , Vrana Michal , Hudek Csilla , Pittarello Marco , Zavattaro Laura , Moretti Barbara , Strauss Peter , Liebhard Gunter , Li Yangyang , Zhang Xiaoping , Bauer Miroslav , Dostál Tomáš , Gomez José A. , Benavente‐Ferraces Iria , García‐Gil Juan C. , Plaza César , Guzmán Gema , Lopez Maria Llanos , Pirkó Bela , Bakacsi Zsofia , Nokolov Dimitre , Krása Josef 
Published: February 2024

AbstractPreventing and reversing soil degradation is essential to maintaining the ecosystem services provided by soils and guaranteeing food security. In addition to the scientific community, it is critical to engage multiple stakeholders to assess the degree of soil degradation and mitigation strategies' impact and meet the United Nations' Sustainable Development Goals, European Union's Common Agricultural Policy, and other national and international goals. A semi‐structured questionnaire was distributed across countries participating in the EU Horizon‐2020 “Transforming Unsustainable management of soils in key agricultural systems in E.U. and China. Developing an integrated platform of alternatives to reverse soil degradation (TUdi).” Using farmers' associations and educational institutions as an intermediate to distribute the questionnaires was an effective strategy for gathering a high number of responses. Results from 456 responses to the questionnaire showed that farm country, size, type of agriculture, and educational level of farm managers were significantly associated with the farmers' perception of soil degradation issues. Farm size and type of agriculture were also correlated with applying a nutrient management plan. The implications of the results for soil conservation measures are discussed. Additionally, we highlight the potential of projects such as TUdi for creating collaboration networks to drive widespread adoption by farmers of technologies to reverse the degradation of agricultural soils.
Stability of a Multi-Span Current-Carrying Beam Resting on Periodic Supports and Exposed to an External Magnetic Field
Authors: Avetisyan A. , Ghazaryan K. , Marzocca P. 
Published: February 2024

Abstract
The stability of a current-carrying beam in an external magnetic field is studied in this paper. The beam rests on periodic supports and is modeled as an Euler–Bernoulli elastic beam. Based on the linearized stability equation and propagator transfer matrix approach for a multi-span finite-length beam, the stability equation and solutions of the several boundary value problems are obtained. While the Floquet–Bloch theory is widely used in the dynamic problem of phononic and photonic structure conditions, its application to the solution of infinite length beam static stability problem is novel. The stability values of the periodic infinite beam model are in very good agreement with one of the finite-length multi-span beams.
A 3D Computational Model of Nanosecond Pulsed Laser Texturing of Metals for Designing Engineered Surfaces
Authors: Narayanan Vishnu , Singh Ramesh , Marla Deepak 
Published: February 2024

Abstract
Laser surface texturing uses a pulsed laser that is scanned on the surface, wherein each pulse creates a micro-crater through material ablation. A variety of textures can be generated depending on the laser parameters and the overlap of the laser spots. This work presents a computational model that can predict the topography of a textured surface produced using a nanosecond pulsed laser. The model involves a multi-physics approach that considers laser ablation with plasma effects and the melt pool’s fluid dynamics to obtain the crater profile for a single pulse. The 3D surface profile created from the multi-physics model is mathematically superimposed to mimic the spatial overlapping of multiple pulses. The model predicts surface topography when a laser is scanned along a linear track with successive overlapping tracks. The experiments have confirmed that the proposed model has an accuracy greater than 90% in predicting surface roughness (Sa), as well as volume parameters such as core void volume (Vvc) and valley void volume (Vvv). It was observed that the variation of these surface characteristics is highly non-linear with the process parameters. Furthermore, the model is used to design engineered surfaces to modify friction coefficient, adhesion, and leakage probability. It is demonstrated that the surface parameters for functional requirements can be modified significantly just by varying the overlap of the laser spots in different directions. The proposed model can be used to create textured surfaces for various applications through an appropriate choice of laser parameters and scanning parameters.
Genome assembly of antimicrobial-resistant
Escherichia coli
HMVC1 isolated from healthy Mogosane village cattle, South Africa
Authors: Makhetha Lerato Lisbeth Njaki , Mokolopi Baitsholetsi Gloria , Oguttu James Wabwire , Mbajiorgu Christian Anayochukwu , Makete Goitsemang , Mamphogoro Tshifhiwa Paris 
Published: February 2024

ABSTRACT

Here, we present the genome assembly of
E. coli
strain HMVC1 isolated from rectal fecal samples of healthy cattle in South Africa. The genome size of HMVC1 consisted of 5,043,843 bp, with G + C content of 50.5%. The strain harbors
mar
A,
mdt
M,
acr
F,
acr
D, and other antimicrobial resistance genes.
Therapeutic hypothermia after perinatal asphyxia in Vietnam: medium-term outcomes at 18 months – a prospective cohort study
Authors: Tran Hang Thi Thanh , Le Ha Thi , Tran Dien Minh , Nguyen Giang Thi Huong , Hellström-Westas Lena , Alfven Tobias , Olson Linus 
Published: February 2024

AimTo determine neurodevelopmental outcome at 18 months after therapeutic hypothermia for hypoxic-ischaemic encephalopathy (HIE) infants in Vietnam, a low-middle-income country.MethodProspective cohort study investigating outcomes at 18 months in severely asphyxiated outborn infants who underwent therapeutic hypothermia for HIE in Hanoi, Vietnam, during the time period 2016–2019. Survivors were examined at discharge and at 6 and 18 months by a neonatologist, a neurologist and a rehabilitation physician, who were blinded to the infants’ clinical severity during hospitalisation using two assessment tools: the Ages and Stages Questionnaire (ASQ) and the Hammersmith Infant Neurological Examination (HINE), to detect impairments and promote early interventions for those who require it.ResultsIn total, 130 neonates, 85 (65%) with moderate and 45 (35%) with severe HIE, underwent therapeutic hypothermia treatment using phase change material. Forty-three infants (33%) died during hospitalisation and in infancy. Among the 87 survivors, 69 (79%) completed follow-up until 18 months. Nineteen children developed cerebral palsy (8 diplegia, 3 hemiplegia, 8 dyskinetic), and 11 had delayed neurodevelopment. At each time point, infants with a normal or delayed neurodevelopment had significantly higher ASQ and HINE scores (p<0.05) than those with cerebral palsy.ConclusionThe rates of mortality and adverse neurodevelopment rate were high and comparable to recently published data from other low-middle-income settings. The ASQ and HINE were useful tools for screening and evaluation of neurodevelopment and neurological function.
Impact of psychosocial factors on the success of neuromodulation treatment for patients with persistent pain
Authors: Goree Johnathan H , Payakachat Nalin , Byers Lauren , Smith G Lawson , Shah Jarna R , Stephens Kimberly E 
Published: February 2024

IntroductionSignificant interindividual variability in spinal cord stimulation (SCS) outcomes exists. Due to its high cost and risks of complications, criteria to guide patient selection for SCS trials and their outcomes would be helpful. With increased focus on the use of patient-reported outcomes to improve care, we aim to evaluate the National Institute of Health Patient Reported Outcome Measurement Information System measures for an association with successful SCS trials in patients with persistent pain.MethodsOur prospective, observational study enrolled 60 patients with persistent pain who underwent an SCS trial. Patients completed demographic and Patient Reported Outcome Measurement Information System computer adaptive test (PROMIS CAT) assessments to measure self-reported pain interference, depression, anxiety, physical functioning, and sleep disturbance at the time they presented for placement of their trial device.ResultsOf the 58 patients who underwent successful electrode placement, 11 had an unsuccessful trial. There were no differences in patient demographics between patients with a successful and an unsuccessful trial. Patients who had a successful SCS trial reported lower pre-trial levels of anxiety, depression, and sleep disturbance and decreased post-trial levels of depression, sleep disturbance, and pain interference.ConclusionsWe found that patients with high levels of depression, anxiety, and sleep disturbance using the PROMIS CAT were predictive of unsuccessful trials. In addition, we found that patients with successful SCS trials reported lower levels of these domains on PROMIS CAT administered at the end of the trial.
Beyond traditional therapies: a network meta-analysis on the treatment efficacy for chronic phantom limb pain
Authors: Chung Sun-Mei , Wang Jui-Chien , Lin Chung-Ren , Liu Shu-Cheng , Wu Po-Ting , Kuan Fa-Chuan , Fang Ching-Ju , Tu Yu-Kang , Hsu Kai-Lan , Lai Pei-Chun , Shih Chien-An 
Published: February 2024

BackgroundPhantom limb pain (PLP) frequently affects individuals with limb amputations. When PLP evolves into its chronic phase, known as chronic PLP, traditional therapies often fall short in providing sufficient relief. The optimal intervention for chronic PLP remains unclear.ObjectiveThe objectives of this network meta-analysis (NMA) were to examine the efficacy of different treatments on pain intensity for patients with chronic PLP.Evidence reviewWe searched Medline, EMBASE, Cochrane CENTRAL, Scopus, and CINAHL EBSCO, focusing on randomized controlled trials (RCTs) that evaluated interventions such as neuromodulation, neural block, pharmacological methods, and alternative treatments. An NMA was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The primary outcome was pain score improvement, and the secondary outcomes were adverse events.FindingsThe NMA, incorporating 12 RCTs, indicated that neuromodulation, specifically repetitive transcranial magnetic stimulation, provided the most substantial pain improvement when compared with placebo/sham groups (mean difference=−2.9 points, 95% CI=−4.62 to –1.18; quality of evidence (QoE): moderate). Pharmacological intervention using morphine was associated with a significant increase in adverse event rate (OR=6.04, 95% CI=2.26 to 16.12; QoE: low).ConclusionsThe NMA suggests that neuromodulation using repetitive transcranial magnetic stimulation may be associated with significantly larger pain improvement for chronic PLP. However, the paucity of studies, varying patient characteristics across each trial, and absence of long-term results underscore the necessity for more comprehensive, large-scale RCTs.PROSPERO registration numberCRD42023455949.