bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socio-Economic Impact of Covid-19 in Bhutan: A Critical Analysis
Authors: Tshewang Dema  , Dr. Ramesh Kumar  
Published: December 2023

Cataclysms are difficult, uncontrollable problems that put societies and nations to the test in terms of how successfully they can protect their infrastructure and population, reduce losses on a material and human level, and recover rapidly. Throughout the beginning of recorded human history, infectious diseases have afflicted people. Over the last four decades, the rise of urbanization, globalization, and population expansion has played a significant role in the escalation of both the occurrence and cross-border dissemination of novel infectious diseases. The discovery of the coronavirus (SARS-CoV-2) and the proliferation of COVID-19 in this world today have prompted many countries to take drastic action. Many economic aspects, not least innovative start-ups, experienced an external shock as a result of the “lockdown” of a sizable portion of society and economic activity. The first cases of COVID-19 in a nation are significant because they have an impact on the nation's response to preparedness, the perception of the pandemic by the general public, and the actions taken by medical professionals. A 76-year-old American man who visited Bhutan as a tourist and was isolated in a separate hospital with a committed medical care staff before being airlifted back to his nation experienced a fortunate turn of events in Bhutan. This patient made Bhutan and its people more careful, and the ensuing steps were so well thought out and wise. The patient's medical team, the government, and the Bhutanese people all took away lessons from this. The COVID-19 recovery effort has been hindered by the government's severe containment measures, which have caused supply chain interruptions, tourism industry problems, and an exodus of expatriate workers, leading to a labor shortage for both trained and unskilled personnel. This gap caused infrastructural projects to stall, which had a negative impact on the average person’s standard of living. Despite the fact that pandemic deaths are frequent, each one has influenced the socioeconomic and public health results, depending on the type and extent of the outbreak. In addition to reflecting on Bhutan's adaptability, responsiveness, and lessons learned, this study sought to provide a preliminary assessment of the COVID-19’s effects on the country. It also sought to provide a deeper understanding of the recent socioeconomic implications of the COVID-19.
SGLT2 inhibitor: metabolic effect on Libyan patients with T2DM at National Diabetes Center in Tripoli
Authors: Elmiladi Samia A , Abdalla Buthina O , FAdala Nour Alhoda 
Published: December 2023

T2DM is a progressive disease with a complex pathophysiology.The kidney plays an important role in glucose homeostasis, partly via the reabsorption of glucose from the glomerular filtrate. Empagliflozinis an effective and highly selectivesodium glucose cotransporter-2 inhibitor ((SGLT2).This study aimedto assess metabolic effect of empagluazin in Libyan patients withuncontrolled T2DM at National Diabetes Center, Tripoli, Libya in 2019.Prospective interventional study, lasting for 24 weeks, included patients with uncontrolled T2DM, given EMPA as an add on oral, once daily, anti-hyperglycemic treatment for patients with inclusion criteria: age ≥18 years, high risk for cardiovascular diseases, patient with established CVD and patient with satisfactory renal function e-GFR > 30 ml/min. Efficacy endpoints are change in HbA1c, bodyweight,Bp, S. Na, fasting LDL-Cfrom baseline at 4 week, 12 weeks and at 24 weeks.Data analysis was done by SPSS program version 16.A total of 40 patients included in the study, female were 70%, mean age was 62.05±9.77, (67.5%)were obese,mean body weight was 89.32±21.75, 67.5% were more than 10 years duration of T2DM, 67.5% were known hypertensive, 72.5% were known CVD. There mean S. Na level were 140± 4.78, their HBA1c were 10.3±1.83, 57.5% with previous history of urinary tract infection, starting Empagliflzin, following with body weight,Bp, urine routine,S Cr,S.Naevery 2-week,4-week,12-week and 24-week and HBA1c, fasting lipid at 12 and 24 week showna reduction in HBA1c by -3.72 to -2.64.Reduction in body weight,especially in initial 4-week and obese casesby-14.4 to -9.78 kg, systolic Bpshows drop especially in hypertensive cases (-10.05 to-4.08) with high S Na at presentation (-4.56 to 1.8),initial mild train set increase in S Cr (0.03to0.19) followed by reduction with moderate improvement in e-GFR (within same stage in CKD),no significant changes in fasting lipid profile may be due to continue intake of statin. In conclusion,Empagliflzin is a potent, anti-hyperglycemic drug with a good metabolic effect showed reductions in glycated hemoglobin, marked reductions in the body weight and systolic Bp, thus, supporting the use of empagliflozin as a mono-therapy or in addition to other glucose-lowering agents especially in patients with T2DM and increased cardiovascular risk
Shewanella Algae Meningitis and Early Onset Neonatal Sepsis
Authors: Almurabet Fathia A , Almamori Kheria O 
Published: December 2023

Neonatal sepsis still a main leading cause of morbidity and mortality among neonates, especially in the developing countries ,Most cases of Neonatal sepsis in neonatal intensive care unit are attributed to GB streptococcus, klebsiellapneumonia and other members of Enterobacteriaceae family.Shewanella algae (S.algae)is a gram –negative saprophytic bacillus, commonly associated with the marine environment,which has been isolated from humans.Early onset neonatal sepsis caused by S.algae is uncommon.Wereporta first case of Shewanella. Algaemeningitis in newborn with early onset neonatal sepsis which was responding to antimicrobial therapy and associated with good early out come and no late neurodevelopmental sequel.
Nugget Tempe: Inovasi Makanan Pencegah Stunting
Authors: Humairoh Fitri , Firdaus Farhan Abdullah , Ulfa Rika Amelia , Gustiani Natasya Fahira , Saputri Dina , Aprina Diana , Nurdianti Lia , Oloan Husna Nabilla , Ramadhan Muhammad Alfin Nur , Ananda Salsabila 
Published: December 2023

Abstract
This research discusses a highly nutritious food innovation, "Tempeh Nugget," developed by Riau University's Real Work Lecture (Kukerta) group in an effort to prevent stunting in Sungai Cingam Village in 2023. Stunting is a serious problem for growing children, with long-term impacts on health and mental development. Indonesian President Joko Widodo set a target of reducing the stunting rate to 14% by 2024. This study involves the socialization of stunting prevention by utilizing food resources, specifically through the food innovation "Tempe Nugget." The implementation method included community service to Sungai Cingam Village, with the implementation of socialization at Posyandu Anggrek. The results showed that stunting can be prevented through attention to nutrition and child growth. Socialization received a positive response from community mothers. With the introduction of the "Tempe Nugget" innovation, it is hoped that mothers can be more concerned about stunting and can create nutritious food menus for their children. In conclusion, stunting prevention efforts need to involve the community innovatively, such as the development of "Tempeh Nuggets" which can help improve children's nutritional status and reduce the risk of stunting.
Keywords: Tempe Nugget, food innovation, stunting prevention, children under five, nutrition, socialization, child growth, nutrition, stunting reduction target

Abstrak
Penelitian ini membahas tentang inovasi makanan bernutrisi tinggi, yaitu "Nugget Tempe," yang dikembangkan oleh kelompok Kuliah Kerja Nyata (Kukerta) Universitas Riau dalam upaya pencegahan stunting di Desa Sungai Cingam pada tahun 2023. Stunting merupakan masalah serius pertumbuhan anak-anak, memiliki dampak jangka panjang terhadap kesehatan dan perkembangan mental. Presiden RI Joko Widodo menetapkan target penurunan angka stunting menjadi 14% pada tahun 2024. Studi ini melibatkan sosialisasi pencegahan stunting dengan memanfaatkan sumber daya pangan, khususnya melalui inovasi makanan "Nugget Tempe." Metode pelaksanaan termasuk pengabdian kepada masyarakat Desa Sungai Cingam, dengan pelaksanaan sosialisasi di Posyandu Anggrek. Hasil menunjukkan bahwa stunting dapat dicegah melalui perhatian terhadap gizi dan pertumbuhan anak. Sosialisasi mendapatkan respon positif dari ibu-ibu masyarakat. Dengan pengenalan inovasi "Nugget Tempe," diharapkan ibu-ibu dapat lebih peduli terhadap stunting dan dapat menciptakan menu makanan bernutrisi untuk anak-anak mereka. Kesimpulannya, upaya pencegahan stunting perlu melibatkan masyarakat secara inovatif, seperti pengembangan "Nugget Tempe" yang dapat membantu meningkatkan status gizi anak dan mengurangi risiko stunting.
Kata Kunci : Nugget Tempe, inovasi makanan, pencegahan stunting, anak balita, gizi, sosialisasi, pertumbuhan anak, nutrisi, target penurunan stunting, kesadaran ibu, menu makanan bernutrisi.
A Study on Opium and Drugs in Namsai District, Arunachal Pradesh: With Special Reference to Emphum Village
Authors: Singkai Chow Nakunand , Tripathy Biplab , Mondal Tanmoy 
Published: December 2023

The Namsai district is the land of multiple tribes‟ viz. Tai-Khamtis, Mishmis, Singphos and some other sub tribes which lie in the eastern parts of Arunachal Pradesh. In this remote and near China-Myanmar border, the district is facing a big problem of drugs for long period of time. Since a long, the poppy had associated with the life of the people due to some myths which is a prime cause of present of opium in this region. Opium is an alkaloid derivative of Papaver somniferum commonly known as poppy. The other derivatives of this plant are Heroin, Morphine, Codine and Papaverum, ganja. Derivatives like Morphine have long been used as medicine. Ages of male addicts are from 20 years onwards. Addiction cause varies. It is seen among youngsters mostly. Opium is sold as per tola, roughly equivalent to 10 grams. This paper attempts to explore the reasons responsible for drug addiction. The reasons are examined in relation to eight hypothetical factors, such as peer group, enjoyment, frustration/tension, sufficient leisure, and excess pocket money, imitation of family elders, easy availability and curiosity. Moreover, the remedial measures undertaken by the Drug De-addiction centres and their benefits among the addicts are also analyzed.
INSUFICIÊNCIA CARDÍACA, DISFUNÇÃO ERÉTIL, DISTÚRBIOS DO SONO E EXERCÍCIO FÍSICO - REVISÃO DE LITERATURA
Authors: Vieira Adriany , De Carvalho Tales , Fachi Jaquelini , Sties Sabrina Weiss 
Published: December 2023

Introdução - A Insuficiência Cardíaca (IC) é caracterizada pela incapacidade do coração em suprir as necessidades fisiológicas do corpo. Afeta aproximadamente cerca de 26 milhões de pessoas no mundo. A IC tem sido associada à ocorrência de disfunção sexual masculina (DS) e distúrbios do sono. Neste contexto, o exercício físico é uma estratégia terapêutica com elevado nível de evidências científicas bem documentadas. Objetivos: descrever os principais mecanismos fisiopatológicos e a repercussão terapêutica do exercício físico nas três morbidades (IC, DE e DRS). Método: Revisão da literatura. As buscas por artigos científicos foram conduzidas de forma manual e intencional, por um único pesquisador, as buscas foram realizadas nas bases de dados eletrônicas (PubMed, LILACS, Cochrane-Library, Science Direct). Considerações Finais: Os resultados apresentados nesta revisão demonstram a relação positiva entre o exercício físico e o controle dessas três condições (IC, DE e DRS), sendo, portanto, fortemente recomendado o seu uso como no tratamento da IC e de algumas morbidades a ela associadas (comorbidades), como a DE e o DRS.
Pertinence of the teaching use of virtual classroom by Basic Biomedical Science Department
Authors: Pomares Bory Eduardo de Jesús , Vázquez Naranjo Odalys , Barrios Herrero Liliam , Arencibia Flores Lourdes Guadalupe , Bernardo Fuentes Manuela Gilda 
Published: December 2023

Introduction: The use of digital technology is recognized as a strategic educational policy in higher education. Objective: To analyze the relevance of the virtual classroom as a teaching tool by the Basic Biomedical Science Department, Salvador Allende Health Sciences Faculty, Medical University of Havana. Methods: A descriptive, qualitative, case study-based research study was conducted. Theoretical methods, including analysis-synthesis, induction-deduction, historical-logical analysis, and ascent from the abstract to the concrete, were used. Empirical methods comprised documentary review and focus groups.Results: Established criteria enable the consideration of the instructional use of the virtual classroom as a departmental teaching innovation. Supported by digital technology, this represents a transition from traditional face-to-face teaching to a hybrid model. Conclusions: The use of the virtual classroom for teaching purposes by the Basic Biomedical Science Department, Salvador Allende Health Sciences Faculty, Medical University of Havana, stands as a pertinent teaching innovation, contributing to the digital transformation of medical education.
KAJIAN KARAKTERISTIK DAN DEFORMASI CAMPURAN AC-WC DENGAN PENGGUNAAN SUBTITUSI LIMBAH MARMER SEBAGAI FRAKSI AGREGAT KASAR
Authors: Bea Liliyan , Basri Lambang , Alifuddin Andi 
Published: December 2023

Repetitive and excessive load pressure by vehicles is one of the damages that occurs on road pavement deformation due to the pavement layer losing its strength, causing the road layer to subside and cracks to occur. Marble waste is the remaining waste acquired from the processing of the marbles. Environmental pollution is caused by the marble processing process. The marble waste produced is increasing gradually over time, therefore, it is needed to utilize that marble waste. The marble waste is expected to improve the quality and performance of the mixture in resisting deformation in the AC-WC mixture and has good mixture characteristics. This research aims to examine the cause of using marble waste on the characteristics and deformation of the mixture. The test in this research applies the marshall test and wheel tracking tool. The result showed that the characteristics of the mixture and KLMO, total deformation, deformation rate, and dynamic stability using KAO 6% and the Optimum Marble Waste Content (KLMO) obtained was 25%. The highest stability and Marshall Quatient were 1024.89 kg and 345.65 kg/mm at 25% marble waste variation. The lowest flow value in the mixture with 25% marble waste variation was 2.97 mm. The 25% variation has good mixture characteristics and durability. The smallest total deformation was 0.903 mm at 25% marble waste variation, dynamic stability 2864 passes/mm, and deformation rate 0.0147 mm/minute.
PENGARUH KEPERCAYAAN NASABAH TERHADAP TABUNGAN HAJI DI BANK SYARIAH INDONESIA
Authors: Mufid Fatiyah 
Published: December 2023

Bank Syariah Indonesia merupakan perbankan syariah terbesar di Indonesia karena hasil penggabungan ketiga bank milik negara. Salah satu produk tabungannya yaitu Tabungan Haji. Yang mana dalam Tabungan haji ini bisa dilakukan untuk perencanaan haji atau umrah dengan menggunakan akad mudharabah. Segmentasi dari Tabungan haji ini bisa untuk semua nasabah dengan kategori produk tabungan yang berbeda. Penelitian ini menggunakan metode kualitatif yang dimana pengambilan data bersumber dari jurnal, buku dan website. Adanya penelitian ini untuk menganalisis kepercayaan nasabah atau masyarakat terhadap Tabungan Haji di BSI. Sehingga kepercayaan nasabah terhadap produk di BSI sangat penting. Penelitian menunjukkan bahwa kepercayaan nasabah untuk menabung di Bank Syariah Indonesia sudah tinggi yang dilihat dari data survey tentang perencaan haji di website BSI.
PULMONARY TB COMPLICATED BY TRACHEOBRONCHIAL TB
Authors:   Central TB Research Institute, Moscow, Russia, Malikova O.G. , Komissarova O.G. ,   Central TB Research Institute, Moscow, Russia,   N.I. Pirogov Russian National Research Medical University, Moscow, Russia, Chumovatov N.V. ,   Central TB Research Institute, Moscow, Russia, Ergeshov A.E. ,   Central TB Research Institute, Moscow, Russia,   A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Published: December 2023

In the recent years we have observed a positive tendency towards better epidemiological rates of TB in the Russian Federation. Incidence and mortality rates fell to a record low. However, a share of patients with advanced or complicated pulmonary TB increased. Our review highlights epidemiological data, pathogenesis, clinical manifestations, diagnostics, and management of pulmonary TB complicated by tracheobronchial TB nowadays.
TUBERCULOSIS OR CANCER: CAUSES OF DIFFERENTIAL DIAGNOSTIC ERRORS
Authors:   Smolensk State Medical University, Smolensk, Russia, Myakisheva T.V. , Idobaeva O.P. ,   Smolensk State Medical University, Smolensk, Russia
Published: December 2023

We carried out an analysis of differential diagnostic errors among patients with cancer diagnosed in TB institutions in Smolensk region in 2017–2021. Delayed diagnostics of tumors in the lungs or pleura was revealed. The causes of overdiagnosis of TB in patients with malignant tumors were as follows: the similarity of clinical and radiological signs of the diseases, the similarity of laboratory test results, false positive results of M. tuberculosis detection in sputum, lack of the recombinant tuberculosis allergen (RTA) test, misinterpretation of radiological data. In indeterminate cases it is vital to verify the diagnosis as soon as possible by performing biopsy from the pathological site.
ETIOLOGICAL VERIFICATION OF PULMONARY MYCOBACTERIOSIS BASED ON EXAMINATION OF RESECTION SAMPLES FROM PATIENTS WITH DIAGNOSIS А16.0 – ACTUAL PRACTICE
Authors:   Central TB Research Institute, Moscow, Russia, Karpina N.L. , Chashchina M.V. ,   Central TB Research Institute, Moscow, Russia, Egorova A.D. ,   Central TB Research Institute, Moscow, Russia, Smirnova T.G. ,   Central TB Research Institute, Moscow, Russia, Bagirov M.A. ,   Central TB Research Institute, Moscow, Russia,   Russian Medical Academy of Postgraduate Education, Moscow, Russia, Ergeshov A.E. ,   Central TB Research Institute, Moscow, Russia,   A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Published: December 2023

Objective: to evaluate effectiveness of etiological verification of pulmonary mycobacteriosis (PM) in patients with diagnosed “pulmonary TB without bacteriological or histological confirmation” (А16.0) as per ICD-10 and species diversity of nontuberculous mycobacteria (NTM) in resection samples from the studied cohort. Materials and methods.We analyzed test results from 28 patients with initially diagnosed “pulmonary TB without bacteriological or histological confirmation” (А16.0) as per ICD-10 and verified PM according to resection sample studies. The microbiological study (at least two sputum samples, one bronchobiopsy sample, and one resection sample) included luminescent microscopy (LUM), extraction of M. tuberculosis DNA or NTM DNA by polymerase chain reaction (PCR), culture growth on liquid media in the ВАСТЕС MGIT 960 system, identification of mycobacteria by molecular genetic methods: real-time PCR for M. tuberculosis DNA detection (Syntol, Russia) and DNA-strip technology (GenoType Mycobacterium CM/AS Hain Lifescience). Results. The analysis of referral diagnoses established that in more than half of patients with diagnosed “pulmonary TB without bacteriological or histological confirmation” (А16.0) changes in the lungs had been referred to tuberculoma (64.3%) or infiltrative TB (21.4%); 28.6% of patients had received TB treatment as per chemotherapy regimen no. 3, and 17.8% of patients – broad-spectrum antibiotics. TB treatment duration varied from 4 to 28 months. Atypical lung resections were performed in most cases (75%). NTM DNA detection in resection samples was the most informative method of etiological verification of PMB (100% of cases). NTM culture growth was observed in 17.9% of cases. Only slowly-growing NTM were represented in the studied cohort as etiologically significant. Conclusion. The diagnosis verification is based on data obtained by microbiological and/or histological, cytological studies. Studies of resection samples from TB suspects significantly improve diagnostic effectiveness.
FLUOROQUINOLONE-BASED SHORT-COURSE CHEMOTHERAPY OF PULMONARY TB IN CHILDREN FROM NIDI OF MULTIDRUG RESISTANT TB: POTENTIALS FOR USE
Authors:   Central TB Research Institute, Moscow, Russia,N.I. Pirogov Russian National Research Medical University, Moscow, Russia, Gubkina M.F , Khokhlova Yu.Yu. ,   Central TB Research Institute, Moscow, Russia, Petrakova I.Yu. ,   Central TB Research Institute, Moscow, Russia, Sterlikova S.S. ,   Central TB Research Institute, Moscow, Russia, Yukhimenko N.V. ,   Central TB Research Institute, Moscow, Russia
Published: December 2023

Objective: to justify the potentials for use of fluoroquinolone-based short-course chemotherapy for the treatment of pulmonary TB in children from nidi of multi-drug resistant TB. Materials and methods. We carried out a cohort prospective study of 18 patients aged 2–5 years with newly diagnosed pulmonary TB with history of exposure to multidrug resistant TB in 2018–2020. The criteria for inclusion were as follows: local or small TB processes without bacterioexcretion, potential to form the initial combination containing at least four TB drugs including fluoroquinolones, use of TB drugs consideringpreserved drug susceptibility in the infection source. The criteria for exclusion: presence of diseases requiring long-term immunosuppressive therapy, administration of bedaquiline at any point of treatment. We used individualized chemotherapy regimens: 4 drugs in the intensive phase and 3 drugs in the continuation phase. The treatment course was 9–12 months. Results. All the patients completed treatment with effective outcomes, no relapse was detected one year later. Intoxication symptoms were removed after 3 months, positive X-ray dynamics was observed after 3 and 6 months in 66.7% of patients. Conclusion. We proved the effectiveness of fluoroquinolone-based short-course chemotherapy regimens in children with local or small forms of TB and history of exposure to multidrug resistant TB. The criteria for the total treatment duration (9 or 12 months) were the duration of the intensive phase and the duration of fluoroquinolone administration. If the intensive phase of treatment was less than 3 months or the administration of fluoroquinolones was less than 6 months, the total treatment duration was prolonged to 12 months.