bluuebunny/crossref_metadata_2025_split huggingface dataset:
MITOS DANAU NIBUNG DI DESA SELAGAN JAYA KABUPATEN MUKOMUKO
Authors: Sakroni Sakroni , Utami Iis 
Published: November 2023

Masalah dalam penelitian ini adalah tentang jawaban masyarakat terhadap Mite Danau Nibung yang ada di Desa Selagan jaya Kabupeten Mukomuko.Penelitian ini bertujuan untuk memperoleh pendeskripsian jawaban masyarakat tentang Mite Danau Nibung. Jenis penelitian ini adalah deskriptif kualitatif. Data dalam penelitian ini adalah jawaban dari responden dari mite yang ada di Danau nibung dan data yang di dapat dari hasil penelitian. Sumber data dalam penelitian ini adalah artikel yang di tulis oleh Wahyu amuk berjudul Asal-usul Legenda Danau Nibung dan wawancara pada masyarakat yang memahami tentang mite Danau Nibung di Desa Selagan Jaya Kabupaten Mukomuko. Pengumpulan data dilakukan dengan teknik observasi, wawancara dan dokumentasi. Hasil penelitian menyatakan bahwa mite di Danau Nibung beragam dan berbeda-beda penuturanya dari setiap responden didasari dari perbedaan usia dan pengetahuan tentang Danau nibung. Mite di Danau nibung diantaranya adalah adanya seorang bernama Nibung yang dahulu tinggal di Danau Nibung, 7 orang penunggu istana dasar Danau Nibung ,kerajaan sakti rantau batuah di Danau Nibung, hal yang menyebabkan Danau nibung bisa di sebut legenda dan keistimewaan danau nibung yang tidak di miliki oleh danau lainya.
PENERAPAN APLIKASI PELAYANAN PUBLIK PADA PENDAFTARAN NPWP SECARA E-REGISTRATION
Authors: Jumiati Siti , Setiawan Budi , Fuadah Luluatul , Maharani Filza Gita , Pratama Orlando Taruna , Kurniawan Irvan Arif 
Published: November 2023

Pajak adalah sumber penerimaan terbesar bagi Negara, maka Pemerintah dalam hal ini terus berupaya meningkatkan kesadaran masyarakat untuk memenuhi kewajiban perpajakannya. Salah satu upaya yang dilakukan Direktorat Jenderal Pajak adalah dengan penerapan sistem teknologi informasi dalam pendaftaran wajib pajak untuk memperoleh Nomor Pokok Wajib Pajak, atau disebut sistem e-Registration. Sistem electronic registration (e-registration) adalah suatu layanan yang diberikan oleh Direktorat Jenderal Pajak untuk memberikan kemudahan untuk Wajib Pajak dalam hal Wajib Pajak yang ingin mendapatkan Nomor Pokok Wajib Pajak, yaitu dapat mendaftarkan dirinya dengan cara online untuk memproses data registrasi Wajib Pajak mulai dari input data hingga pengaktivasi jumlah fundamental wajib pajak (NPWP) dan pencetakan kartunya di KPP manapun. Sedangkan untuk fiskus atau petugas pajak memudahkannya dalam memberikan pelayanan kepada calon Wajib Pajak yang datang ke Kantor Pelayanan Pajak. Penelitian ini bertujuan untuk mengetahui dan menggambarkan proses praktik penerapan Aplikasi e-Registration dalam permohonan pendaftaran NPWP dan untuk meninjau bagaimana pelaksanaan pelayanan penyelesaian permohonan pendaftaran NPWP melalui Aplikasi e-Registration. Penelitian ini merupakan penelitian dengan studi literatur, sumber dan metode pengumpulan data dengan mengambil data di pustaka, membaca, mencatat, dan mengolah bahan penelitian.
PENGARUH METODE OUTDOOR LEARNING BERBANTU MEDIA KARYA SENI MOZAIK TERHADAP PEMBENTUKAN KARAKTER SISWA KELAS IVSD NEGERI 2 GALI SARI
Authors: Sukarelawati Cici , Noviati  , Robert Budi Laksana  
Published: November 2023

Mozaik merupakan pembuatan karya seni rupa dua dimensi atau tiga dimensi yang menggunakan material dan bahan dari keping-kepingan yang sengaja di buat atau di potong-potong kemudian disusun dan ditempelkan pada bidang datar dengan cara di lem. Dalam pembelajaran sebelum menggunakan Metode Outdoor Learning Berbantu Media Karya Seni Mozaik terbilang rendah. Oleh karenaitu, penelitian ini bertujuan untuk mengetahui ada Pengaruh Metode Outdoor Learning Berbantu Media Karya Seni Mozaik Terhadap Pembentukan Karakter Siswa Kelas IV SD Negeri 2 Gali Sari. Penelitian ini di laksanakan pada tanggal 27 Mei 2023-15 juni 2023. Jenis penelitian ini adalah kuantitatif dengan jumlah populasi seluruh siswa kelas IV yang berjumlah 27 orang. Teknik pengumpulan data dengan menggunakan observasi, tes dan dokumentasi. Berdasarkan hasil nilai rata-rata pretest yang diperoleh 33,5 lebih rendah dari pada nilai rata-rata posttest yaitu sebesar 81,8 dapat diketahui ada peningkatan nilai yang diperoleh siswa. Berdasarkan analisis Uji Hipotesis menggunakan Uji T pada tabel t-test one sample test memperoleh nilai Sig. ( 2- tailed) sebesar 0,000. Dapat diketahui jika nilai signifikansi < 0,05, maka dapat disimpulkan Ho ditolak dan Ha diterima. Maka dapat disimpulkan bahwa ada pengaruh metode Outdoor Learning berbantu media karya seni mozaik terhadap pembentukan karakter siswa.
PENGARUH RAGI DALAM FORMULA SAKURA BLOK TERHADAP KONSUMSI BAHAN KERING, PERTAMBAHAN BERAT BADAN DAN EFISIENSI PAKAN KAMBING LOKAL
Authors: Jarmuji  , Santoso Urip , Badarina I 
Published: November 2023

Penelitian ini bertujuan untuk mengevaluasi pengaruh ragi dalam sakura blok terhadap konsumsi Bahan Kering (BK), Pertambahan Berat Badan (PBB) dan efisiensi pakan kambing lokal. Sakura blok adalah pakan suplemen dalam bentuk blok yang terbuat dari bahan-bahan seperti gula kelapa kualitas rendah, dedak padi, jagung giling, sagu, urea, TSP, garam, mineral mix dan top mix. Penelitian ini menggunakan rancangan acak lengkap 3 perlakuan dan 4 ulangan dimana P1(rumput lapangan), P1 (rumput lapangan + sakura blok) dan P3(rumput lapangan + sakura blok+ragi). Hasil penelitian menunjukkan bahwa konsumsi bahan kering P1(46.79 gram/hari), P2(53,76 gr/hari), P3 (54.71 gram/hari), pertambahan bobot badan P1(24,42 gram/hari), P2(32,83 gram/hari), P3(36,64 gram/hari) sedangkan efisiensi pakan P1(7,24%), P2(7,74) and P3(11,16). Kambing lokal yang mengkonsumsi sakura blok maupun sakura blok yang mengandung ragi nyata menghasilkan pertambahan berat badan lebih tinggi dibanding kelompok kambing yang hanya mengkonsumsi rumput lapangan saja.
Kata kunci: Kambing Lokal, Sakura Blok, Ragi, Pertambahan Berat Badan
An SiO Toroid and Wide-angle Outflow Associated with the Massive Protostar W75N(B)-VLA2
Authors: Gómez José F. , Torrelles José M. , Girart Josep M. , Surcis Gabriele , Kim Jeong-Sook , Cantó Jorge , Anglada Guillem , Curiel Salvador , Vlemmings Wouter H. T. , Carrasco-González Carlos , Rodríguez-Kamenetzky Adriana R. , Kim Soon-Wook , Goddi Ciriaco , van Langevelde Huib J. , Sanchez-Monge Álvaro 
Published: November 2023

Abstract
We have carried out Atacama Large Millimeter/submillimeter Array observations of the massive star-forming region W75N(B), which contains the massive protostars VLA1, VLA2, and VLA3. Particularly, VLA2 is an enigmatic protostar associated with a wind-driven H2O maser shell, which has evolved from an almost isotropic outflow to a collimated one in just 20 yr. The shell expansion seemed to be halted by an obstacle located to the northeast of VLA2. Here we present our findings from observing the 1.3 mm continuum and H2CO and SiO emission lines. Within a region of ∼30″ (∼39,000 au) diameter, we have detected 40 compact millimeter continuum sources, three of them coinciding with VLA1, VLA2, and VLA3. While the H2CO emission is mainly distributed in a fragmented structure around the three massive protostars, but without any of the main H2CO clumps spatially coinciding with them, the SiO is highly concentrated on VLA2, indicating the presence of very strong shocks generated near this protostar. The SiO emission is clearly resolved into an elongated structure (∼0.″6 × 0.″3; ∼780 au×390 au) perpendicular to the major axis of the wind-driven maser shell. The structure and kinematics of the SiO emission are consistent with a toroid and a wide-angle outflow surrounding a central mass of ∼10 M
⊙, thus supporting previous theoretical predictions regarding the evolution of the outflow. Additionally, we have identified the expected location and estimated the gas density of the obstacle that is hindering the expansion of the maser shell.
TCR Pathway Mutations in Mature T Cell Lymphomas
Authors: Zhang Yue , Cheng Kathleen , Choi Jaehyuk 
Published: November 2023

Abstract
Mature T cell lymphomas are heterogeneous neoplasms that are aggressive and resistant to treatment. Many of these cancers retain immunological properties of their cell of origin. They express cytokines, cytotoxic enzymes, and cell surface ligands normally induced by TCR signaling in untransformed T cells. Until recently, their molecular mechanisms were unclear. Recently, high-dimensional studies have transformed our understanding of their cellular and genetic characteristics. Somatic mutations in the TCR signaling pathway drive lymphomagenesis by disrupting autoinhibitory domains, increasing affinity to ligands, and/or inducing TCR-independent signaling. Collectively, most of these mutations augment signaling pathways downstream of the TCR. Emerging data suggest that these mutations not only drive proliferation but also determine lymphoma immunophenotypes. For example, RHOA mutations are sufficient to induce disease-relevant CD4+ T follicular helper cell phenotypes. In this review, we describe how mutations in the TCR signaling pathway elucidate lymphoma pathophysiology but also provide insights into broader T cell biology.
Challenges and Prospects in Developing Future SARS-CoV-2 Vaccines: Overcoming Original Antigenic Sin and Inducing Broadly Neutralizing Antibodies
Authors: Evans John P , Liu Shan-Lu 
Published: November 2023

Abstract
The impacts of the COVID-19 pandemic led to the development of several effective SARS-CoV-2 vaccines. However, waning vaccine efficacy as well as the antigenic drift of SARS-CoV-2 variants has diminished vaccine efficacy against SARS-CoV-2 infection and may threaten public health. Increasing interest has been given to the development of a next generation of SARS-CoV-2 vaccines with increased breadth and effectiveness against SARS-CoV-2 infection. In this Brief Review, we discuss recent work on the development of these next-generation vaccines and on the nature of the immune response to SARS-CoV-2. We examine recent work to develop pan-coronavirus vaccines as well as to develop mucosal vaccines. We further discuss challenges associated with the development of novel vaccines including the need to overcome “original antigenic sin” and highlight areas requiring further investigation. We place this work in the context of SARS-CoV-2 evolution to inform how the implementation of future vaccine platforms may impact human health.
Cost estimation of COVID Kavach test developed in 2020: A National Reference Laboratory initiative during early phase of Indian pandemic mitigation
Authors: Sambhare Susmit Balkrishna , Gurav Yogesh Krishnarao , Minhas Naveen , Sapkal Gajanan N. , Deshpande Gururaj Rao , Ullas Padinjaremattathil Thankappan , Shete Anita , Abraham Priya 
Published: November 2023

Background & objectives:
A new indigenously developed technology, coronavirus disease (COVID) Kavach, an IgG immunoglobulin-based enzyme-linked immunosorbent assay (ELISA) kit, was developed in 2020 by the Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India. The primary objective of this study was to determine the total cost of development of COVID Kavach IgG ELISA and estimate the unit cost (UC) as well.

Methods:
The total development cost (TDC) of COVID Kavach and its UC during the early phase of pandemic mitigation were estimated through a micro-costing approach from provider’s perspective. An activity-based bottom-up costing approach was used to facilitate data collection from all resources, and analysis was performed using Microsoft Excel version 2016. The micro-costing data were utilized to interpret the breakdown of cost across all inputs and different levels of activity.

Results:
The TDC of COVID Kavach was estimated to be

JOURNAL/ijmer/04.03/02223309-202310000-00007/363FF04/v/2023-11-25T134903Z/r/image-tiff

2,884,032 (US$ 38,265). The UC of providing test results for exposure to severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) was estimated to be

JOURNAL/ijmer/04.03/02223309-202310000-00007/363FF04/v/2023-11-25T134903Z/r/image-tiff

300 (US$ 4) during July 2020. The capital and recurrent cost were incurred around 5-10 per cent and 90-95 per cent, respectively, in both the development and UC of COVID Kavach. The major portion of funds (70-80%) was utilized for procurement of laboratory consumables, followed by human resources (8-12%) in the development as well as for UC of COVID Kavach.

Interpretation & conclusions:
The estimates from this study can be useful for conducting economic evaluations, which will help in deciding upon the subsidy in government health facilities. The data may be useful to set up laboratory facilities analogous to the National Reference Laboratory located at the ICMR-NIV, Pune and for allotting sufficient budget to develop such assays in government-funded laboratories.
Three-dimensional of lingual arch form and creation of templates in Iraqi normal occlusion
Authors: Razzaq Ali Jamal Abdul , Dewachi Zaid 
Published: November 2023

OBJECTIVES:
To evaluate the lingual dental arch form types in class I canine and molar relationship based on scanning dental cast models using three-dimensional laser scan and to give a new lingual arch form pattern created on this classification to be used for clinical submission by studying three-dimensional virtual models of the normal occlusion samples.

MATERIALS AND METHODS:
Maxillary and mandibular casts of 120 young adults (18-24 ± 1.84 years) have normal occlusion that was scanned using a 3Shape E1 laser scanner, and then, the data were analyzed using SPSS software; then, we used K-means cluster to classify the arch form into clusters depending on the measurement of 10 landmarks designated on the lingual surface of the teeth.

RESULTS:
Many dental arch patterns have been established for both the mandible and the maxilla.

CONCLUSION:
The minimum sizes were found in the females, and the biggest sizes were found in the male subjects, and three sets were well defined for each sex; three categories for each mandible and maxilla are as follows: narrow, mid, and broad. The lingual arch form can be classified into three groups based on posterior and anterior dimensions, so a template of the three arch forms has been exemplified.
Effect of Mini-implant assisted Micro-osteoperforation on the rate of orthodontic tooth movement—A randomized clinical trial
Authors: Singh Shresthaa , Jain Abhay K. , Prasad Raghu R. , Sahu Anshu , Priya Parul , Kumari Priyanka 
Published: November 2023

OBJECTIVE:
To evaluate the effectiveness of micro-osteoperforation (MOP) over a 56-day period and to determine the influence of number of perforations on the rate of canine retraction. In addition, the amount of pain and discomfort caused by the MOP was evaluated.

TRIAL DESIGN:
A single-center, split-mouth, triple-blind, randomized, controlled trial.

METHODS:
22 patients (18–30 years) who need fixed orthodontic treatment were recruited and randomly assigned to MOP1 and MOP2 groups. The recruited patients were divided into two groups with 1:1 allocation ratio. Randomization for the determination of experimental side and number of perforations was done using sealed envelopes. On each patient, the other side of mouth worked as control side with no MOPs. 4 months after first premolar extraction, patients in MOP1 received 3MOPs on the buccal surface of alveolar bone, whereas patients in MOP2 received three buccal and three palatal MOPs in the experimental side. The amount of canine retraction was measured every 28 days at two intervals on both sides of mouth. Pain perception was measured after 1 hr, 24 hr, 72 hr, 7 days, and 28 days of procedure.

RESULTS:
Result of the intra-examiner reliability using ICC is more than 0.97 (P < 0.001), indicating excellent repeatability and reliability of the measurements. The baseline characteristics between groups were similar (P > 0.05). A statistically significant difference in the rate of canine retraction on the MOP side was observed at the end of 56 days, amounting to two folds more than that of the control side. No significant difference was seen between MOP1 and MOP2 groups (P > 0.05). Mild-to-moderate pain was experienced only in first 72 hours of procedure.

CONCLUSION:
The study recommends that MOP procedure has substantial potential to be used as an adjunct to the routine mechanotherapy for accelerating tooth movement, as it may reduce treatment time by half in the first four weeks after the MOP procedure.

TRIAL REGISTRATION:
Clinical trial registry of India (CTRI/2022/12/048181).
Canine retraction and anchorage loss using self-ligating and conventional brackets with sliding mechanics: A split-mouth clinical study
Authors: Tiwari Anurag , Aafaque Syed , Rizwana Y , Quadri Syed Altafuddin , Kanagasabapathy B , Villuri Chandrika , Babu J Suresh , Swarnalatha C , Nayyar Abhishek Singh 
Published: November 2023

OBJECTIVE:
Appliance biocompatibility, orthodontic treatment efficiency and patient convenience are the major issues confronting contemporary orthodontic practice. Very few studies have been published till date regarding the efficiency of self-ligating brackets as against conventional brackets. Hence, the present study was planned to compare the rate of canine retraction between self-ligating and conventional brackets and to determine the amount of anchorage loss during canine retraction.

METHODS:
The present clinical study was designed as a prospective, observational study comprising of 25 patients requiring first premolar extraction as a part of orthodontic treatment. Self-ligating and conventional brackets were bonded using a split-mouth study design randomly. Retraction of canines was done with 150 grams of force using Dontrix gauge with E-chains. The study was conducted in relation to upper arch only, while the rate of retraction was evaluated every 4 weeks for 3 months. Average rates of retraction in 3 months were calculated. For anchorage loss, an acrylic guide plug was used in mid-treatment cast (T0) and after 3 months of retraction (T3). The statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 17.0 (SPSS Inc., Chicago, IL, USA). Independent t-test was used to compare the means of the two variables studied, while Pearson's correlation coefficient was used to evaluate the correlation between the variables studied in the groups included. P < .05 was considered statistically significant.

RESULTS:
The correlation coefficient between the average rate of canine retraction with self-ligating brackets vs. conventional brackets over a period of 3 months came out to be 0.6434, while on comparing the data in terms of anchorage loss over a period of 3 months, the respective correlation coefficient value was found to be 0.6659 with the results being statistically highly significant in either case (P < .001).

CONCLUSIONS:
Self-ligating brackets showed double the amount of displacement compared to conventional brackets in some of the cases. Also, chair side time was significantly reduced with self-ligating brackets as against conventional brackets.
Comparison of shear bond strength of composite resin, compomer, and resin-modified glass-ionomer cements in primary teeth: An in-vitro study
Authors: Kumar R Kranthi , Subramani Savadamoorthi Kamatchi , Swathika B , Ganesan S , Chikkanna Meenakumari , Murugesan Sabari , Babu J Suresh , Swarnalatha C , Nayyar Abhishek S. 
Published: November 2023

OBJECTIVE:
The contemporary esthetic restorative materials such as composite resin and glass-ionomer cements and their modifications have all been developed keeping in mind the requirements of permanent teeth. There have been plenty of studies that have focused on the characteristics of these materials in relation to permanent teeth with a relative dearth of such studies as regard to the primary teeth. The present study was undertaken to compare and evaluate the shear bond strength of composite resin, compomer, and resin-modified glass-ionomer cements in primary teeth.

METHODS:
Thirty non-carious primary molars that were indicated for extraction because of physiological resorption or, for orthodontic reasons, were selected. The selected teeth were randomly allocated to three groups of 10 each for composite, compomer, and resin-modified glass-ionomer cements. The enamel from the occlusal surface of all teeth was removed to expose the superficial dentin and was wet polished with 400 grit sand paper. Composite, compomer, and resin-modified glass-ionomer stubs were bonded on to the occlusal surfaces using a plastic tube as a template. All samples were, then, subjected to thermocycling and evaluation of shear bond strength using the universal testing machine at a cross-head speed of 0.5 mm/min, whereas the results obtained were subjected to statistical analysis. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) version 17.0 (SPSS Inc., Chicago, IL, USA), whereas one-way analysis of variance (ANOVA) and Tukey's multiple post-hoc procedures were used for statistical analysis. A P < 0.05 was considered statistically significant.

RESULTS:
The mean shear bond strength values for Groups I, II, and III were found to be 11.7 ± 3.07 MPa, 7.74 ± 4.16 Mpa, and 4.43 ± 2.08 Mpa, respectively, whereas one-way ANOVA and Tukey's multiple post-hoc procedures indicated that there were remarkable differences among the three groups with the results being statistically significant (P < 0.05).

CONCLUSIONS:
Composite resin showed the highest shear bond strength in relation to primary dentin when compared to compomer and resin-modified glass-ionomer cements.
Investigation of the change in the degree of Frankfort mandibular plane angle after levelling the curve of spee in different malocclusion groups
Authors: Fawaz V , Purushothaman Binu , Siyo Rasool Karim Nizaro , Naseem KT , Ashok Amrita , Bavitha TK 
Published: November 2023

BACKGROUND AND OBJECTIVES:
The curve of Spee is a naturally occurring phenomenon in the human dentition. Leveling the curve of Spee can affect the Frankfort-mandibular plane (FMP) Angle and thus the lower anterior facial height. This study examined the degree of change in FMP angle after leveling the curve of Spee in different malocclusion groups.

METHODS:
In this study, 75 patients who were aged >14 years and had undergone fixed appliance therapy using a 0.022-slot MBT bracket system were included. The pre- and post-treatment casts and lateral cephalograms of the patients were divided into three groups, namely Class I, II, and III malocclusions, with 25 patients in each group. The curve of Spee and FMP angle were measured before and after orthodontic treatment, and their correlation was evaluated.

RESULTS:
After leveling the curve of Spee, the FMP angle decreased in Class I and II groups and increased in Class III group. These results were statistically significant except in Class I malocclusion group. A mild positive correlation was observed between the curve of Spee and FMP angle in Class I and III malocclusion groups and a negative correlation in Class II malocclusion group.

CONCLUSION:
The change in FMP angle, following the leveling of the curve of Spee, in Class II and III malocclusion group, is attributed to alterations in lower anterior facial height. The study observed a mild positive correlation between the curve of Spee and FMP angle in Class I and III malocclusion groups and a negative correlation in Class II malocclusion group.