bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
Authors: van Dyck Christopher H. , Mecca Adam P. , O’Dell Ryan S. , Bartlett Hugh H. , Diepenbrock Nina G. , Huang Yiyun , Hamby Mary E. , Grundman Michael , Catalano Susan M. , Caggiano Anthony O. , Carson Richard E. 
Published: January 2024

Abstract
Background
Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ oligomers are among the most toxic forms of Aβ. CT1812 is a novel brain penetrant sigma-2 receptor ligand that interferes with the binding of Aβ oligomers to neurons. Preclinical studies of CT1812 have demonstrated its ability to displace Aβ oligomers from neurons, restore synapses in cell cultures, and improve cognitive measures in mouse models of AD. CT1812 was found to be generally safe and well tolerated in a placebo-controlled phase 1 clinical trial in healthy volunteers and phase 1a/2 clinical trials in patients with mild to moderate dementia due to AD. The unique objective of this study was to incorporate synaptic positron emission tomography (PET) imaging as an outcome measure for CT1812 in AD patients.

Methods
The present phase 1/2 study was a randomized, double-blind, placebo-controlled, parallel-group trial conducted in 23 participants with mild to moderate dementia due to AD to primarily evaluate the safety of CT1812 and secondarily its pharmacodynamic effects. Participants received either placebo or 100 mg or 300 mg per day of oral CT1812 for 24 weeks. Pharmacodynamic effects were assessed using the exploratory efficacy endpoints synaptic vesicle glycoprotein 2A (SV2A) PET, fluorodeoxyglucose (FDG) PET, volumetric MRI, cognitive clinical measures, as well as cerebrospinal fluid (CSF) biomarkers of AD pathology and synaptic degeneration.

Results
No treatment differences relative to placebo were observed in the change from baseline at 24 weeks in either SV2A or FDG PET signal, the cognitive clinical rating scales, or in CSF biomarkers. Composite region volumetric MRI revealed a trend towards tissue preservation in participants treated with either dose of CT1812, and nominally significant differences with both doses of CT1812 compared to placebo were found in the pericentral, prefrontal, and hippocampal cortices. CT1812 was safe and well tolerated.

Conclusions
The safety findings of this 24-week study and the observed changes on volumetric MRI with CT1812 support its further clinical development.

Trial registration
The clinical trial described in this manuscript is registered at clinicaltrials.gov (NCT03493282).
Inheritance of growth ring components and the possibility of early selection for higher wood density in Japanese cedar (Cryptomeria japonica D. Don)
Authors: Yasuda Yuko , Iki Taiichi , Takashima Yuya , Takahashi Makoto , Hiraoka Yuichiro , Mishima Kentaro 
Published: January 2024

Abstract
Key message
We elucidated the age trends of narrow-sense heritability and phenotypic/genetic correlations and the age–age genetic correlation of growth ring components of Cryptomeria japonica D. Don by investigating progenies of controlled crossings by soft X-ray densitometry analysis. Wood density in the C. japonica breeding program can be efficiently improved by selecting trees with a higher earlywood density and latewood percentage as early as forest stand ages of 5–9 years.

Context
Wood density within the trunk is affected by the intra-ring wood density profile and its age trend from pith to bark. Wood density can be efficiently improved by clarifying whether wood density and highly correlated intra-ring components are under additive genetic control.

Aims
The aim of this study was to elucidate the age trends of narrow-sense heritability and phenotypic/genetic correlations of growth ring components and investigate the possibility of early selection for improving wood density in Cryptomeria japonica.

Methods
We quantified seven growth ring components (width, density, earlywood/latewood width, average earlywood/latewood density, and latewood percentage) for 5112 annual rings of 342 18-year-old trees derived from 24 controlled pollinated full-sib families of C. japonica plus tree clones by soft X-ray densitometry analysis. Genetic parameters and correlations among the seven growth ring components were analyzed using a linear mixed model and the breedR package.

Results
Earlywood density and latewood percentage exhibited a higher phenotypic and genetic correlation with ring density than the other ring components at almost all ages. Earlywood density and latewood percentage exhibited a lower correlation with ring width than the other ring components after a stand age of 5 years. The age–age genetic correlation of earlywood density and latewood percentage was 0.70 for a stand age of 17 years and was strong at stand ages of 5 and 9 years.

Conclusion
Efforts focusing on improving earlywood density and latewood percentage may contribute to improving wood density efficiently in tree breeding programs for C. japonica. Traits related to the ring density of C. japonica trees can possibly be selected as early as stand ages of 5–9 years, and the required period for progeny selection may be substantially shortened when selecting trees with high wood density.
On a Duffing-type oscillator differential equation on the transition to chaos with fractional q-derivatives
Authors: Houas Mohamed , Samei Mohammad Esmael , Sundar Santra Shyam , Alzabut Jehad 
Published: January 2024

AbstractIn this paper, by applying fractional quantum calculus, we study a nonlinear Duffing-type equation with three sequential fractional q-derivatives. We prove the existence and uniqueness results by using standard fixed-point theorems (Banach and Schaefer fixed-point theorems). We also discuss the Ulam–Hyers and the Ulam–Hyers–Rassias stabilities of the mentioned Duffing problem. Finally, we present an illustrative example and nice application; a Duffing-type oscillator equation with regard to our outcomes.
Dynamical analysis of a novel fractional order SIDARTHE epidemic model of COVID-19 with the Caputo–Fabrizio(CF) derivative
Authors: Zhao Yu , Li Tian-zeng , Kang Rong , He Xi-liang 
Published: January 2024

AbstractFabrizio and Caputo suggested an extraordinary definition of fractional derivative, which has been used in many fields. The SIDARTHE infectious disease model with regard to COVID-19 is studied by the new notion in this paper. Making use of the Banach fixed point theorem, the existence and uniqueness of the model’s solution are demonstrated. Then, an efficient method is utilized to deduce the iterative scheme. Finally, some numerical simulations of the model under various fractional orders and parameters are shown. From the computed result, we can see that it not only supports the theoretical demonstration, but also has an intensive insight into the characteristics of the model.
Improving efficiency of DNN-based relocalization module for autonomous driving with server-side computing
Authors: Li Dengbo , Zhang Hanning , Cheng Jieren , Liu Bernie 
Published: January 2024

AbstractThe substantial computational demands associated with Deep Neural Network (DNN)-based camera relocalization during the reasoning process impede their integration into autonomous vehicles. Cost and energy efficiency considerations may dissuade automotive manufacturers from employing high-computing equipment, limiting the adoption of advanced models. In response to this challenge, we present an innovative edge cloud collaborative framework designed for camera relocalization in autonomous vehicles. Specifically, we strategically offload certain modules of the neural network to the server and evaluate the inference time of data frames under different network segmentation schemes to guide our offloading decisions. Our findings highlight the vital role of server-side offloading in DNN-based camera relocation for autonomous vehicles, and we also discuss the results of data fusion. Finally, we validate the effectiveness of our proposed framework through experimental evaluation.
Incidence of catheter-associated urinary tract infections by Gram-negative bacilli and their ESBL and carbapenemase production in specialized hospitals of Bahir Dar, northwest Ethiopia
Authors: Asmare Zelalem , Awoke Tewachew , Genet Chalachew , Admas Alemale , Melese Addisu , Mulu Wondemagegn 
Published: January 2024

Abstract
Background
Catheter-associated urinary tract infections (CAUTIs) due to multidrug-resistant Gram-negative bacilli (GNB) is a common concern globally. Investigating the incidence of CAUTI and associated antibiotic resistance has paramount importance from the health care associated infections perspective. This study therefore assessed the incidence of CAUTIs due to GNB and the production of extended-spectrum beta-lactamase (ESBL) and carbapenemase among inpatients in specialized hospitals of Northwest, Ethiopia.

Methods
A total of 363 patients with indwelling urinary catheters who were admitted in the hospital for > 48 h were consecutively enrolled and followed from 3 to 18 days. Data were collected through interviewing and review of medical records. Patients who developed at least one of the following: fever (> 38 OC), suprapubic tenderness, or costovertebral angle pain, coupled with a GNB positive urine culture of ≥ 103 CFU/mL with no more than two bacterial species were defined as CAUTI. The ESBL and carbapenemase production were detected and identified by chromogenic medium. Logistic regression analysis was done to identify associated factors.

Results
From 363 patients followed, the incidence rate of CAUTI was 27.8 per 1000 catheter days. Catheterization for ≥ 8 days (AOR = 10.6, 95%CI:1.8–62.1) and hospitalization for > 10 days (AOR = 8.1, 95%CI: 2.4–27.2) were the factors significantly associated with CAUTIs. E. coli (n = 18, 34.6%), Proteus species (n = 7, 13.5%), and P. aeruginosa (n = 6, 11.5%) were the most frequent GNB. Isolates revealed high rates of resistance to amoxicillin-clavulanic acid (100%), cefazolin (n = 51, 98%), ceftazidime (n = 47, 90%) and cefotaxime (n = 46, 88%). Most of the GNB isolates (86.5%) were multidrug-resistant. Overall, 19.2% and 5.8% of GNB isolates were ESBL and carbapenemase producers, respectively.

Conclusions
Incidence of CAUTI with Gram-negative bacilli is high. As most of the GNB isolates are MDR and showed a super high rate of resistance to amoxicillin-clavulanic and third-generation cephalosporins, empirical treatment with these substances is virtually ineffective in patients with suspected GNB infection in Ethiopia. The expression of ESBL and carbapenemase among GNB isolates is also a concern. Therefore, improved infection prevention and control measures, careful use of catheters and third generation of cephalosporins are needed to improve patient outcomes and reduce the burden of CAUTIs and the spreading of antimicrobial resistance.
Mechanical and moisture-related properties of selected dried tempera paints
Authors: Poznańska Katarzyna , Hola Aleksandra , Kozłowski Roman , Strojecki Marcin , Bratasz Łukasz 
Published: January 2024

Abstract
Mechanical properties—modulus of elasticity and strain at break, water vapour sorption, and hygroscopic expansion of selected egg tempera and distemper paints were determined as a function of relative humidity (RH) filling in this way a critical gap in the knowledge required for the analysis of fracturing processes in paintings. The experimental work was made possible by the preparation of several tempera paints, mimicking the historical materials, in the form of large specimens. Lead white, azurite, and yellow ochre were selected as pigments, and egg yolk and rabbit skin glue as binding media. The water vapour sorption and the moisture-related swelling of the paints were dominated by the proteinaceous components of the binders. The linear hygroscopic expansion coefficient of the dried egg yolk binder was approximately 1 × 10−4 per 1% RH, several times less than the coefficient of the collagen glue (4 × 10−4 per 1% RH). The moduli of elasticity of egg tempera paints at the RH mid-range were comparable to the moduli of aged oil paints, whilst the modulus of elasticity of the distemper paint was close to values measured for animal glue-based grounds. The paints experienced the transition from brittle to ductile states on increasing RH. The egg tempera paints were found to be more brittle than the distemper paint, gessoes, and, generally, aged oil paints. The observations modify a frequently used laminar model of panel paintings in which the mismatch in the response of glue-based ground layer and wood substrate to variations in RH has been identified as the worst-case condition for the fracturing of the entire pictorial layer. This study demonstrated that tempera could be more brittle than the ground layer and in consequence more vulnerable to cracking.
Structural characterization of a low-molecular weight linear O-acetyl-glucomannan in Lilium lancifolium from Tibet and its protected H2O2-induced oxidative stress in HUVEC cells
Authors: Yuan Lei , Zhong ZhengChang , Liu Yu , Quan Hong , Lan XiaoZhong 
Published: January 2024

AbstractIn recent years, the biological activity of plant polysaccharides has received increasing attention. Polysaccharides, as one of the main components of lilies, have pharmacological effects in regulating immunity, anti-tumor, antioxidant, antibacterial, and hypoglycemic effects. To systematically analyze the structural characteristics of the polysaccharide, the polysaccharide LP-1 was prepared from Lilium lancifolium bulbs by water extraction and ethanol precipitation, ion exchange chromatography and gel filtration chromatography. Structural characterizations show that the weight-average relative molecular weight of LP-1 is 5.3 kDa. LP-1 consists of mannose and glucose at a molar ratio of 1.4:1. Its primary structure is Glcp-α-D-(1 → {4)-β-D-Glcp-(1 → 4)-β-D-2-O-acetyl-Manp-(1 → [4)-β-D-Glcp-(1 → 4)-β-D-Glcp-(1 → 4)-β-D-Manp-(1 → 4)-β-D-Manp-(1 → 4)-β-D-Manp-(1 → 4)-β-D-Manp-(1]2}2 → 4)-α-D-Glcp. Acetylation occurs at the O-2 site of mannose. Acetyl substitution degree is 8.21%. The results of structure elucidation showed that LP-1 was a low-molecular weight linear O-acetylated glucomannan. The results of oxidative stress experiments indicate that LP-1 exerts antioxidant effects on HUVEC by activating the Nrf2/HO-1 signaling pathway, thereby improving endothelial cell damage induced by H2O2, and has the potential to be developed as an antioxidant drug.
Graphical Abstract
Pre-service elementary teachers’ science and engineering teaching self-efficacy and outcome expectancy: exploring the impacts of efficacy source experiences through varying course modalities
Authors: Hammack Rebekah , Yeter Ibrahim H. , Pavlovich Christina , Boz Tugba 
Published: January 2024

Abstract
Background
Teacher efficacy is one of the most influential components for effective instruction, highlighting the importance of providing preservice teachers (PSTs) with opportunities to learn how to teach engineering during their college preparatory coursework. Making space for engineering instruction within science methods coursework could provide opportunities for PSTs to enhance their engineering teaching efficacy but also requires course instructors to give up some time previously devoted to science-focused instruction. The purpose of the current study was to explore how infusing engineering learning opportunities into a science methods course impacts PSTs’ engineering and science teaching efficacy and outcome expectancy.

Results
Pre/post-surveys were completed by PSTs enrolled in a Kindergarten-8th grade science methods course offered in four modalities (i.e., face-to-face, hybrid, online, rapid shift online). The course offered multiple engineering-focused learning activities and vicarious experiences. PSTs’ science teaching efficacy beliefs, engineering teaching efficacy beliefs, science teaching outcome expectancy, and engineering teaching outcome expectancy all significantly increased from pre- to post-test. There was no significant difference between efficacy gains based on course modality. The purposeful inclusion of multiple engineering activities and vicarious experiences allows for significant gains in science and engineering teaching efficacy and outcome expectancy regardless of the modality in which the course is taken.

Conclusions
This study shows that having varied efficacy source experiences while learning engineering design can result in increased efficacy, even in the absence of field experience and face-to-face coursework, and that the inclusion of these engineering experiences with science methods coursework does not detract from enhancing science teaching efficacy beliefs and outcome expectancy. Further research is needed to more closely examine individual components of science methods courses and the impacts each component has when implemented using different course modalities.
Resorbable bilayer membrane made of L-lactide-ε-caprolactone in guided bone regeneration: an in vivo experimental study
Authors: Watanabe Taito , Hasuike Akira , Wakuda Shin , Kogure Keisuke , Min Seiko , Watanabe Norihisa , Sakai Ryo , Chaurasia Akhilanand , Arai Yoshinori , Sato Shuichi 
Published: January 2024

Abstract
Purpose
Guided bone regeneration (GBR) is an accepted method in dental practice that can successfully increase the bone volume of the host at sites chosen for implant placement; however, existing GBR membranes exhibit rapid absorption and lack of adequate space maintenance capabilities. We aimed to compare the effectiveness of a newly developed resorbable bilayer membrane composed of poly (l-lactic acid) and poly (-caprolactone) (PLACL) with that of a collagen membrane in a rat GBR model.

Methods
The rat calvaria was used as an experimental model, in which a plastic cylinder was placed. We operated on 40 male Fisher rats and subsequently performed micro-computed tomography and histomorphometric analyses to assess bone regeneration.

Results
Significant bone regeneration was observed, which was and similar across all the experimental groups. However, after 24 weeks, the PLACL membrane demonstrated significant resilience, and sporadic partial degradation. This extended preservation of the barrier effect has great potential to facilitate optimal bone regeneration.

Conclusions
The PLACL membrane is a promising alternative to GBR. By providing a durable barrier and supporting bone regeneration over an extended period, this resorbable bilayer membrane could address the limitations of the current membranes. Nevertheless, further studies and clinical trials are warranted to validate the efficacy and safety of The PLACL membrane in humans.
Predictors of lack of glycemic control in persons with type 2 diabetes
Authors: Louie Judy Z. , Shiffman Dov , Rowland Charles M. , Kenyon Norma S. , Bernal-Mizrachi Ernesto , McPhaul Michael J. , Garg Rajesh 
Published: January 2024

Abstract
Background
Professional guidelines recommend an HbA1c < 7% for most people with diabetes and < 8.5% for those with relaxed glycemic goals. However, many people with type 2 diabetes mellitus (T2DM) are unable to achieve the desired HbA1c goal. This study evaluated factors associated with lack of improvement in HbA1c over 3 years.

Methods
All patients with T2DM treated within a major academic healthcare system during 2015–2020, who had at least one HbA1c value > 8.5% within 3 years from their last HbA1c were included in analysis. Patients were grouped as improved glycemic control (last HbA1c ≤ 8.5%) or lack of improvement (last HbA1c > 8.5%). Multivariate logistic regression analysis was performed to assess independent predictors of lack of improvement in glycemic control.

Results
Out of 2,232 patients who met the inclusion criteria, 1,383 had an improvement in HbA1c while 849 did not. In the fully adjusted model, independent predictors of lack of improvement included: younger age (odds ratio, 0.89 per 1-SD [12 years]; 95% CI, 0.79–1.00), female gender (1.30, 1.08–1.56), presence of hypertension (1.29, 1.08–1.55), belonging to Black race (1.32, 1.04–1.68, White as reference), living in low income area (1.86,1.28–2.68, high income area as reference), and insurance coverage other than Medicare (1.32, 1.05–1.66). Presence of current smoking was associated with a paradoxical improvement in HbA1c (0.69, 0.47—0.99). In a subgroup analysis, comparing those with all subsequent HbA1c values > 8.5% (N = 444) to those with all subsequent HbA1c values < 8.5% (N = 341), similar factors were associated with lack of improvement, but smoking was no longer significant.

Conclusion
We conclude that socioeconomic factors like race, type of insurance coverage and living in low-income areas are associated with lack of improvement in HbA1c over a period of 3-years in people with T2DM. Intervention strategies focused on low-income neighborhoods need to be designed to improve diabetes management.
Excess stock returns and corporate environmental performance in China
Authors: Ma Dandan , Zhai Pengxiang , Zhang Dayong , Ji Qiang 
Published: January 2024

AbstractUsing unbalanced panel data on 3326 Chinese listed companies from 2014 to 2021, this study investigates the impact of corporate environmental performance on China’s excess stock returns. The results show that stocks of companies with better environmental performance earn significantly higher excess returns, indicating the existence of green returns in the Chinese stock market. We further reveal that heightened climate-change concerns can boost the stock market’s green returns, while tightened climate policies decrease green returns by increasing long-term carbon risk. Our findings are robust to endogeneity problems and hold great implications for both investors and policymakers.
Retinal capillary perfusion heterogeneity in diabetic retinopathy detected by optical coherence tomography angiography
Authors: Yuan Po Hsiang , Athwal Arman , Shalaby Mena , Mehnert Andrew , Yu Dao-Yi , Preti Rony C. , Sarunic Marinko , Navajas Eduardo V. 
Published: January 2024

Abstract
Background
Diabetic retinopathy (DR) is a leading cause of blindness and involves retinal capillary damage, microaneurysms, and altered blood flow regulation. Optical coherence tomography angiography (OCTA) is a non-invasive way of visualizing retinal vasculature but has not been used extensively to study blood flow heterogeneity. The purpose of this study is to detect and quantify blood flow heterogeneity utilizing en-face swept source OCTA in patients with DR.

Methods
This is a prospective clinical study which examined patients with either type 1 or 2 diabetes mellitus. Each included eye was graded clinically as no DR, mild DR, or moderate-severe DR. Ten consecutive en face 6 × 6 mm foveal SS-OCTA images were obtained from each eye using a PLEX Elite 9000 (Zeiss Meditec, Dublin, CA). Built-in fixation-tracking, follow-up functions were utilized to reduce motion artifacts and ensure same location imaging in sequential frames. Images of the superficial and deep vascular complexes (SVC and DVC) were arranged in temporal stacks of 10 and registered to a reference frame for segmentation using a deep neural network. The vessel segmentation was then masked onto each stack to calculate the pixel intensity coefficient of variance (PICoV) and map the spatiotemporal perfusion heterogeneity of each stack.

Results
Twenty-nine eyes were included: 7 controls, 7 diabetics with no DR, 8 mild DR, and 7 moderate-severe DR. The PICoV correlated significantly and positively with DR severity. In patients with DR, the perfusion heterogeneity was higher in the temporal half of the macula, particularly in areas of capillary dropout. PICoV also correlates as expected with the established OCTA metrics of perfusion density and vessel density.

Conclusion
PICoV is a novel way to analyze OCTA imaging and quantify perfusion heterogeneity. Retinal capillary perfusion heterogeneity in both the SVC and DVC increased with DR severity. This may be related to the loss of retinal capillary perfusion autoregulation in diabetic retinopathy.