bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma
Authors: Hirose Kosuke , Toshima Takeo , Tobo Taro , Kai Satohiro , Hirakawa Masakazu , Higuchi Satoshi , Ofuchi Takashi , Hosoda Kiyotaka , Yonemura Yusuke , Hisamatsu Yuichi , Masuda Takaaki , Aishima Shinichi , Mimori Koshi 
Published: February 2024

Abstract
Background
Nodular regenerative hyperplasia (NRH) is a rare disease that presents pathologically as diffuse hepatic nodules without fibrous septa. It is believed to be caused by vasculopathy against a background of various systemic diseases, such as hematologic, autoimmune, and drug-induced diseases, with various symptoms. In spite of the recent imaging advances, various atypical cases of nodular lesions are observed in daily clinical practice. Cases that do not completely meet these criteria are referred to as -like or -similar lesions in clinical situations, making it difficult to understand their pathogenesis. We present a case in which two hepatic nodular lesions were noted and difficult to differentiate from malignancy preoperatively. The lesions were laparoscopically resected and a pathological diagnosis with non-neoplastic liver regenerative nodules resembling NRH was made.

Case presentation
A 49-year-old man with no alcohol or drug intake and no past medical history was identified as having liver tumors on screening examination without any symptoms. Contrast-enhanced computed tomography (CT) showed two hepatic tumors; approximately 2-cm tumors at S7 and S8. Gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) revealed fat inclusions in their contents. Ethoxybenzyl (EOB) uptake was also observed during the hepatobiliary phase. Based on preoperative examinations, we suspected well-differentiated hepatocellular carcinoma (HCC) and performed laparoscopic S7/8 partial resection for these lesions. Macroscopically, the resected specimens showed a non-cirrhotic yellowish-cut surface containing brownish, ill-defined lesions with irregular borders. Microscopically, these lesions showed zonal necrosis, congestion, and aggregation of hemosiderin-laden macrophages around the central vein. In these areas, the fatty deposition of hepatocytes was lower than that in the surrounding background hepatocytes. Histopathologically, neither neoplastic nor hyperplastic lesions were observed, and he was diagnosed as regenerative hepatic change with centrilobular necrosis.

Conclusions
Considering the pathological results, these lesions were thought to be a type of NRH-like lesion with possible hepatic vessel disorder. However, the lesion’s cause and classification was difficult to determine. The accumulation of these regenerative changes accompanying fatty liver is needed to clarify the mechanism and its clinical significance.
A randomized trial evaluating the utility of non-targeted biopsies for colorectal neoplasia detection in adults with inflammatory bowel disease: a pilot study protocol
Authors: Murthy Sanjay K. , Marderfeld Luba , Fergusson Dean , Ramsay Tim , Bernstein Charles N. , Nguyen Geoffrey C. , Jairath Vipul , Riddell Robert 
Published: February 2024

Abstract
Background
Persons with inflammatory bowel diseases are at increased risk of developing colorectal cancer and require frequent colonoscopy surveillance. Guidelines recommend taking 30 to 40 non-targeted biopsies throughout the colorectum to detect “invisible” neoplasia in this setting, despite a lack of evidence supporting this practice. We sought to assess the utility of this practice through a randomized controlled trial. We first propose an internal pilot study to assess recruitment potential, protocol adherence and data capture to guide the full trial.

Methods
We have designed a multi-centre, parallel-group, non-inferiority randomized controlled trial to test the utility of non-targeted biopsies as an adjunct to colonoscopy surveillance for neoplasia detection in persons with inflammatory bowel disease involving the colorectum in routine clinical practice. Participants are randomized 1:1, stratified by study site, to either standard of care high-definition white-light colonoscopy with 32 to 40 non-targeted biopsies of non-neoplastic-appearing mucosa along with a sampling of abnormal-appearing mucosa (control group) or modified colonoscopy with targeted sampling alone (intervention group). The primary outcome for the full trial will be the proportion of persons with ≥ 1 neoplastic focus detected during colonoscopy. For the pilot phase, we will assess the feasibility of recruiting a minimum of 15% of the estimated sample size within 1 year, under identical conditions as the full trial, while maintaining ≥ 90–95% rate of protocol adherence and data capture. These participants will contribute data to the full trial. The trial is being conducted at 12 centres across Canada, with a total sample size of 1952 persons.

Discussions
The trial protocol has been approved by the ethics committees of all participating sites, and the pilot study has received funding through the Canadian Institutes of Health Research (PJT 159607). If feasibility metrics are met during the pilot phase, we will complete the full trial. The trial outcomes will contribute to update the practice guidelines in this area.

Trial registration
ClinicalTrials.gov, NCT04067778.
Association of dietary fats with ischemic heart disease (IHD): a case–control study
Authors: Zeinalabedini Mobina , Ladaninezhad Maryam , Mobarakeh Khadijeh Abbasi , Hoshiar-Rad Anahita , Shekari Soheila , Askarpour Seyed Ali , Ardekanizadeh Naeemeh Hassanpour , Esmaeili Mina , Abdollahi Morteza , Doaei Saeid , Khoshdooz Sara , Ajami Marjan , Gholamalizadeh Maryam 
Published: February 2024

Abstract
Background
This study aimed to investigate the association between different types of dietary fats with ischemic heart disease (IHD).

Methods
This case–control study was conducted on 443 cases and 453 controls aged 40–80 years in Tehran, Iran. The semi-quantitative 237-item food frequency questionnaire (FFQ) was used to assess the amount of food intake. Nutritionist IV was applied to test the amount of consumption of dietary fats.

Results
The case group had a lower intake of docosahexaenoic acid (DHA) (11.36 ± 12.58 vs. 14.19 ± 19.57, P = 0.01) than the control group. A negative association was found between IHD and DHA (OR 0.98, CI 95% 0.97–0.99, P = 0.01). No significant association was observed between IHD with the intake of cholesterol, trans fatty acids (TFA), saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), eicosatetraenoic acid (EPA), and α-Linolenic acid (ALA).

Conclusion
It was found that DHA may reduce the risk of IHD, whereas there was no significant association between other types of dietary fats with the odds of IHD. If the results of this study are confirmed in future research, a higher intake of DHA in diet can be recommended as a strategy to prevent IHD events.
Convolutional neural network based data interpretable framework for Alzheimer’s treatment planning
Authors: Parvin Sazia , Nimmy Sonia Farhana , Kamal Md Sarwar 
Published: February 2024

AbstractAlzheimer’s disease (AD) is a neurological disorder that predominantly affects the brain. In the coming years, it is expected to spread rapidly, with limited progress in diagnostic techniques. Various machine learning (ML) and artificial intelligence (AI) algorithms have been employed to detect AD using single-modality data. However, recent developments in ML have enabled the application of these methods to multiple data sources and input modalities for AD prediction. In this study, we developed a framework that utilizes multimodal data (tabular data, magnetic resonance imaging (MRI) images, and genetic information) to classify AD. As part of the pre-processing phase, we generated a knowledge graph from the tabular data and MRI images. We employed graph neural networks for knowledge graph creation, and region-based convolutional neural network approach for image-to-knowledge graph generation. Additionally, we integrated various explainable AI (XAI) techniques to interpret and elucidate the prediction outcomes derived from multimodal data. Layer-wise relevance propagation was used to explain the layer-wise outcomes in the MRI images. We also incorporated submodular pick local interpretable model-agnostic explanations to interpret the decision-making process based on the tabular data provided. Genetic expression values play a crucial role in AD analysis. We used a graphical gene tree to identify genes associated with the disease. Moreover, a dashboard was designed to display XAI outcomes, enabling experts and medical professionals to easily comprehend the prediction results.
Exchange-traded funds and the future of passive investments: a bibliometric review and future research agenda
Authors: Joshi Girish , Dash Ranjan Kumar 
Published: February 2024

AbstractPassive investments such as exchange-traded funds (ETFs) provide an opportunity to invest in indexes, asset classes, and sectors with low maintenance costs and high transparency. Today ETFs dominate the world, with nearly 50% of the investment in the USA coming through ETFs. Numerous studies on specific aspects on ETFs have been done earlier; however, considering the scarcity of thorough summaries in the existing body of literature, this bibliometric and systematic review aims to adopt a methodical approach with the goal of delivering qualitative and quantitative understanding of ETFs, while highlighting general research trends. The authors analyzed 2058 articles associated with ETFs from the Scopus database during the last 50 years, i.e., from 1973 till date. The search was initially conducted using title, keyword, and abstract, yielding 2058 articles, which were narrowed to only include research papers and review papers, resulting in a final count of 958 items. The most important authors, highest cited articles, prominent journals, important themes, and associated countries have been identified using bibliometric research. The numerical and visual representations of the analysis show that ETFs are a widely studied research area, and the enormous rise in publications in 2020, 2021, and 2022 demonstrates that researchers are quite interested in the topic. According to affiliation statistics, most research is focused in the USA together with other developed nations, opening new options for the research on ETFs in relation to developing economies. The current analysis reconciles numerous exchange-traded fund studies associated with volatility, liquidity, risk-return trade-off, and tracking errors and identifies possible research gaps. Some of the emerging topics that evolved in passive investments include the use of machine learning, AI, and the emergence of ETFs associated with ESG and sustainability. This research will help lawmakers, scholars, and regulators understand the core principles of ETFs and identify areas that deserve additional investigation.
Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank
Authors: Chen Xiaowan , Hu Kejia , Song Huan , Yin Li , Kaijser Magnus , Gurholt Tiril P. , Andreassen Ole A. , Valdimarsdóttir Unnur , Fang Fang , Duan Maoli 
Published: February 2024

Background
Hearing loss and tinnitus have been proposed as potential indicators of impaired mental health and brain morphological changes.

Aims
To assess the associations of hearing loss and tinnitus with the risk of depression and anxiety and with brain volume.

Method
We conducted a community-based cohort study including 129 610 participants aged 40−69 years at recruitment to the UK Biobank with a follow-up period during 2006–2021 to estimate the risk of depression and anxiety after detection of hearing loss and reported tinnitus. We also assessed the associations of hearing loss and tinnitus with brain volume in a subsample with available brain magnetic resonance imaging data (N = 5222).

Results
We observed an increased risk of depression among individuals with hearing loss (hazard ratio [HR] 1.14, 95% CI 1.03–1.26), tinnitus (HR 1.30, 95% CI 1.21–1.41) or both (HR 1.32, 95% CI 1.15–1.52), compared with individuals with neither hearing loss nor tinnitus. Similar results were noted for anxiety (HR 1.18, 95% CI 1.07–1.30 for hearing loss; HR 1.32, 95% CI 1.22–1.43 for tinnitus; and HR 1.48, 95% CI 1.30–1.68 for both). Hearing loss was associated with decreased overall brain volume as well as decreased volume of different brain regions. The latter associations disappeared after adjustment for whole intracranial volume. Tinnitus was associated with greater left accumbens and right occipital pole volume after adjustment for the whole intracranial volume.

Conclusions
Individuals with tinnitus are at increased risk of depression and anxiety. Hearing loss, on the other hand, is associated with both mood disorders and altered brain morphology.
Changes in the Epidemiologic Pattern of Primary CNS Tumors in Response to the Aging Population: An Updated Nationwide Cancer Registry Data in the Republic of Korea
Authors: Byun Yoon Hwan , Ha Johyun , Kang Ho , Park Chul-Kee , Jung Kyu-Won , Yoo Heon 
Published: February 2024

PURPOSE Primary CNS tumors (PCNSTs) are tumors originating from the brain and surrounding tissues. These tumors account for a significant proportion of cancer deaths and morbidity globally. Accurate epidemiologic data are essential for shaping clinical practices, research priorities, and health care policies. This study presents the latest 2020 national data on PCNSTs from the Republic of Korea (ROK) and explores the trends in incidence and their societal implications in the context of an aging population. METHODS This is a cross-sectional, observational study conducted using data sourced from the Korea National Cancer Incidence Database by the Korea Central Cancer Registry. The study analyzed national data on PCNSTs in the ROK for the years 2010, 2013, 2016, and 2020. RESULTS In 2020, 15,568 new PCNST cases were diagnosed in the ROK. The overall crude rate was 30.32, and the age-standardized rate was 19.37 per 100,000 persons. A decade-long trend analysis revealed an increasing trend in newly diagnosed glioblastoma and lymphoma, and a decreasing trend in embryonal tumors, in relation to the aging population of the ROK. CONCLUSION This study shows the significant impact of demographic shifts on the epidemiologic patterns of PCNSTs in the ROK. Our findings emphasize the need for collaborative efforts to address the rising challenges posed by the changing incidence of PCNSTs related to an aging population.
The efficacy and safety of tinengotinib in patients with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC).
Authors: Hongqian Guo , Subudhi Sumit Kumar , Han Weiqing , Liao Chih-Yi , Zhang Shun , Dai Tao , Peng Peng , Sun Caixia , Wang Hui , Hennessy Katie , Fu Ximei , Yu Yingying , Wu Yingtong , Li Qing , Xu Ruolan , Huang Peng , Neo Levin , Wu Frank , Fan Jean , Piha-Paul Sarina A. 
Published: February 2024

133 Background: Tinengotinib is a spectrum-selective multi-kinase inhibitor that targets cell proliferation, angiogenesis, and immune-oncology pathways by inhibiting Aurora kinases A/B, Janus kinases (JAK), and receptor tyrosine kinases (FGFRs, VEGFRs). It has been reported that the activation of JAK/STAT and fibroblast growth factor receptor (FGFR) signaling drives prostate tumor plasticity. Here we present the preliminary safety and efficacy data of tinengotinib in patients with mCRPC from three early phase clinical trials conducted in the US and China. Methods: Eligible mCRPC patients who have no available standard therapeutic treatment options were enrolled to the three studies. Tinengotinib was given as monotherapy at 8 mg QD, 10 mg QD and 12 mg QD. Efficacy tumor assessments were based on RECIST v1.1 for measurable disease and Prostate Cancer Working Group 3 criteria for non-measurable (bone) disease. PSA50 response was also evaluated. CTCAE v5.0 was used for safety assessments. Results: As of 28AUG2023, 30 patients with mCRPC were treated at dose levels of 8 mg QD (n=1), 10 mg QD (n=19) and 12 mg QD (n=10). Median age was 67 years (range 52-82) with ECOG performance status of 1 in 93% of patients. All patients had at least 2 prior therapies including 77% prior docetaxel, 87% prior abiraterone, and 30% prior enzalutamide. The median follow-up time is 5.4 months. Twenty-two (22) patients were efficacy evaluable, of which 13 were evaluable per RECIST v1.1. Fourteen (14) patients were PSA evaluable. The median radiographic progression-free survival (rPFS) was 5.6 months (95% CI, 3.3-7.3). Overall response rate (ORR) was 46% (6/13) and the disease control rate (DCR) was 85% (11/13). Median duration of response (DoR) was 3.0 months. The PSA50 response rate was 50% (7/14). Treatment-related adverse events (TRAEs) occurred in 28 patients (93%). The most common TRAEs (≥20%) included blood thyroid stimulating hormone increase (43%), anemia (37%), hypertension (27%), aspartate aminotransferase increase (23%), electrocardiogram QT prolongation (20%) and white blood cell count decrease (20%). Conclusions: Tinengotinib safety profile was tolerable and manageable. The preliminary efficacy data showed promising clinical benefit of tinengotinib monotherapy in patients with heavily pretreated mCRPC. Further study of tinengotinib in this disease is warranted. Clinical trial information: NCT03654547 , NCT04742959 , NCT05253053 .
Body Mass Index and Uterine Fibroid Development: A Prospective Study
Authors: Harmon Quaker E , Patchel Stacy , Denslow Sheri , Wegienka Ganesa , Baird Donna D 
Published: February 2024

Abstract

Objective
Fibroids are hormonally dependent uterine tumors. The literature on adiposity and fibroid prevalence is inconsistent. Previous work usually combined all those with a body mass index (BMI) ≥30 kg/m2 into a single category and relied on clinically diagnosed fibroids, which misclassifies the many women with undiagnosed fibroids. We used a prospective cohort design with periodic ultrasound screening to investigate associations between repeated measures of BMI and fibroid incidence and growth assessed at each follow-up ultrasound.

Methods
The Study of Environment, Lifestyle & Fibroids followed 1693 Black/African American women, ages 23 to 35 years from Detroit, Michigan, with ultrasound every 20 months for 5 years. Measured height and repeated weight measures were used to calculate BMI. Fibroid incidence was modeled using Cox models among those who were fibroid free at the enrollment ultrasound. Fibroid growth was estimated for individual fibroids matched across visits as the difference in log-volume between visits and was modeled using linear mixed models. All models used time-varying BMI and adjusted for time-varying covariates.

Results
Compared with BMI &lt;25 kg/m2, those with BMI 30 to &lt;35 kg/m2 had increased fibroid incidence (adjusted hazard ratio, 1.37; 95% CI, 0.96-1.94), those with BMI ≥40 kg/m2 had reduced incidence (adjusted hazard ratio, 0.61; 95% CI, 0.41-0.90). Fibroid growth had mostly small magnitude associations with BMI.

Conclusion
BMI has a nonlinear association with fibroid incidence, which could be driven by effects of BMI on inflammation and reproductive hormones. More detailed measures of visceral and subcutaneous adiposity and their effects on hormones, DNA damage, and cell death are needed.
Conrad, Lawrence, and the Sabotage and Salvage of Genre
Authors: McGowan Christopher 
Published: February 2024

Abstract
This article considers Joseph Conrad's Nostromo and D. H. Lawrence's Women in Love as modernist reworkings of the industrial novels of the mid-nineteenth century, such as Elizabeth Gaskell's Mary Barton and Charles Dickens's Hard Times. Conrad and Lawrence, the article argues, rework the industrial-novel genre as a way to figure a crisis of British culture—and of the novel as a form. In the era of British imperial decline, the apparent massification and globalization of modern Western culture, and revolutionary changes in gender relations and family life, the synoptic historical narratives of Nostromo and Women in Love describe the transformation of the earlier promise of development into an apocalyptic present, and, in turn, the dissolution of the progressive assurance of the realist novel. While the nineteenth-century novels plead for reform and paternalistic care to moderate but protect the free market and liberalism, Nostromo and Women in Love narrate precisely the historical fulfillment of this wish—but, then, in turn, also narrate the end of that reformist logic and the triumph of a fully globalized and “perfected” capitalism, which they characterize as worse than the free-market capitalism that the earlier novels both criticize and celebrate. Drawing on Marxist-feminist theories of “social reproduction,” the article describes especially how the modernist novels imagine the family as a machine for maintaining and servicing capitalist production: the regeneration of the family—a trope so important to the resolution of plot in the realist novel—is now a sign of decay instead of resilience.
Scenario Fiction and the Novel Claims of Insurance
Authors: Gutman Jennifer 
Published: February 2024

AbstractEmerging during a Cold War era of nuclear uncertainty, refined in decades of neoliberal turbulence, and used today for modeling climate futures, scenario thinking has now entered the domain of the Anthropocene novel. This article argues for the adoption of scenarios as a formal strategy of two contemporary realist novels engaged in updating the genre to present scales of crisis: Tom McCarthy's Remainder (2005) and Ben Lerner's 10:04 (2014). As these novels process new forms of risk in a time of epochal fracture, they likewise signal a conceptual break in realism's capacity to imagine new configurations for the present based on the shape of things past. Scenarios prioritize plausibility over predictability, emphasizing the importance of storytelling in processing an age of planetary crisis while also showing the limits of statistical methods of world-building. By attending to the many configurations that could emerge from the volatile state of the present, scenario fiction seeks to preempt unmediated outcomes and insure the novel's critical extension into all possible futures.