bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low expression of GALNT6 gene in gliomas promotes immune infiltration and improves tumor prognosis using bioinformatics analysis
Authors: Jiang Qiaoji , Dong Hongjin , Huang Yue , Wei Min , Yang Yu , Sun Zesheng , Peng Long , Wan Zhengqiang 
Published: October 2023

Abstract
Background
The variation in the expression of GALNT6, an enzyme responsible for adding N-acetylgalactosamine, is linked to the growth of cancer cells and has the potential to serve as a novel indicator for the diagnosis and prognosis of tumors. However, its role and mechanisms in gliomas have not been thoroughly investigated. Our study aimed to examine the GALNT6 expression and its correlation with immune infiltration in gliomas, along with its prognostic significance in gliomas.
Methods
Access to the Cancer Genome Atlas database is available to assess tumor prognostic indicators, we analyzed the survival rate and expected survival time. The Kaplan-Meier method was utilized to create survival curves. Examining the correlation between GALNT6 and longevity through Cox regression and Nomogram forecasting models. Examining the correlation between clinicopathological characteristics and GALNT6 expression through logistic regression analysis. We also examined the mRNA expression of GALNT6 in tumour tissues and paracancerous tissues of glioma patients by RT-qPCR. The effect of interfering with GALNT6 expression in U87 cells was detected using Transwell cell invasion assay and cell scratch assay.
Results
The findings revealed a strong correlation between decreased GALNT6 expression and the status of isocitrate dehydrogenase (IDH), as well as a significantly improved overall survival rate.The prognosis of glioma may be influenced by factors such as the status of isocitrate dehydrogenase (IDH), codeletion of 1p/19q, age, and GALNT6 levels. The analysis of GO and KEGG pathways revealed the involvement of three signaling pathways in the regulation of the interaction between extracellular vesicles and GALNT6. In contrast, the mRNA level expression of GALNT6 in the paracancerous tissues was significantly lower than that in the tumour tissues, and the degree of cell invasion and migration were significantly reduced after interfering with the expression of GALNT6 in U87 cells.
Conclusions
Based on our analysis, it was found that reduced GALNT6 expression could potentially impede tumor advancement and enhance favorable prognosis to a certain degree.
Deep AngioKey: A Novel Approach for Objective Keyframe Extraction in Coronary Angiography Analysis
Authors: Moalla Hounaida , Ghrab Aiman , Bahloul Amine , Hamed Bassem Ben , Abid Leila 
Published: October 2023

Abstract
Coronary angiography represents the GOLD standard for diagnosing and treating obstructive coronary artery disease. Its analysis relies on cardiologist?s visual assessment which is subjective and leads to inter-observer variability and different treatment strategies. Objective methods have been proposed and implemented in catheterization laboratories. However, their input is manually chosen by the cardi-ologist. In this paper, we present a new coronary angiogram keyframe extraction, Deep AngioKey. It is based on feature extraction. The frame with the highest vessel structure was identified as keyframe. Feature extraction was done using a U-Net model trained for binary vessel segmentation. Our solution surpassed existing methods and reached an overall accuracy of 98.1% in keyframe identification with an average main frame distance of 1.63.
Valorization of waste paper sludge as a sustainable source for packaging applications
Authors: Quintana Elisabet , Valls Cristina , Roncero M. Blanca 
Published: October 2023

Abstract
Paper sludge consists mainly of wet short cellulose fibers that are lost during papermaking and of residual chemicals used in the manufacturing process that remain dissolved in the water. Each ton of paper generates about 40–50 kg of dry sludge, of which 70% is primary sludge. Paper production, which exceeded 400 million tons globally in 2020, generates vast volumes of solid waste. Primary sludge is usually fiber-rich and hence suitable to be recycled back into the papermaking process. However, if the sludge is to be disposed of in landfills, sustainable practices must be developed in order to recover the fibers as they are valuable source for manufacturing high value added products.
This study investigates the valorization of paper sludge discarded by a filter paper manufacturer, with the purpose of producing cellulose acetate films for food packaging. The process involves recovering cellulose fibers from the sludge, purifying them and through acetylation reaction produce cellulose acetate films. FTIR spectra confirmed successful acetylation of fibers and also that acetyl groups reduced the hydrophilicity of cellulose —the contact angle was increased to over 80° from 50° in native cellulose. The films exhibited very good water barrier properties at both 50% and 90% RH.
Neural signatures of imaginary motivational states: desire for music, movement and social play
Authors: Vedova Giada Della , Proverbio Alice Mado 
Published: October 2023

Abstract
The literature has demonstrated the potential for detecting accurate electrical signals that correspond to the will or intention to move, as well as decoding the thoughts of individuals who imagine houses, faces or objects. This investigation examines the presence of precise neural markers of imagined motivational states through the combining of electrophysiological and neuroimaging methods. 20 participants were instructed to vividly imagine the desire to move, listen to music or engage in social activities. Their EEG was recorded from 128 scalp sites and analysed using individual standardized Low-Resolution Brain Electromagnetic Tomographies (LORETAs) in the N400 time window (400–600 ms). The activation of 1056 voxels was examined in relation to the 3 motivational states. The most active dipoles were grouped in eight regions of interest (ROI), including Occipital, Temporal, Fusiform, Premotor, Frontal, OBF/IF, Parietal, and Limbic areas. The statistical analysis revealed that all motivational imaginary states engaged the right hemisphere more than the left hemisphere. Distinct markers were identified for the three motivational states. Specifically, the right temporal area was more relevant for "Social Play", the orbitofrontal/inferior frontal cortex for listening to music, and the left premotor cortex for the "Movement" desire. This outcome is encouraging in terms of the potential use of neural indicators in the realm of brain-computer interface, for interpreting the thoughts and desires of individuals with locked-in syndrome.
Identification of mitophagy-related subgroups and biomarker in AIS osteopenia based on bioinformatics and machine learning approaches
Authors: Liu Jiahao , Wu Hui , Miao Xinxin , Wu Tianlong , Cheng Xigao 
Published: October 2023

Abstract

Background: Adolescent idiopathic scoliosis (AIS) is a complicated spinal deformity with an unknown origin. The progression of AIS and the severity of spinal curvature are both substantially linked to osteopenia. Mitophagy is critical for the balance of osteogenic and osteoclastic development in BMSCs, but its significance in AIS osteopenia is unknown. The goal of this work was to look into the mechanism of mitophagy in AIS osteopeniapatients' BMSCs and give a new diagnostic and therapeutic target for AIS osteopenia.
Methods: The gene expression profiles of BMSCs from AIS patients are available in the Gene Expression Omnibus (GEO) collection. Consensus cluster analysis of mitophagy-related genes was used to identify molecular isoforms.Using machine learning, identify mitophagy-related diagnostic indicators of osteopenia in AIS. The biological function and immunological features of diagnostic biomarkers were then assessed using GSEA and ssGSEA.
Results: Immune cell infiltration was found to differ between mitophagy-related subtypes, implying that the development of AIS osteopenia may be associated with immune cell infiltration. UBA52 was identified as the best mitophagy-related diagnostic biomarker for osteopenia in AIS by machine learning methods, and GSEA revealed that UBA52 mostly affected osteopenia in AIS through oxidative phosphorylation. In addition, UBA52 regulates immune cell infiltration and may contribute to osteopenia in AIS patients.
Conclusion: According to our findings, AIS patients can be split into two mitophagy subgroups. Furthermore, we used machine learning to identify UBA52, a mitophagy-related diagnostic marker, and discovered that UBA52 played a significant role in increasing osteopenia in AIS.
Classification of Diverse AI Generated Content: An In-Depth Exploration using Machine Learning and Knowledge Graphs
Authors: Vora Vismay , Savla Jenil , Mehta Deevya , Gawade Aruna , Mangrulkar Ramchandra 
Published: October 2023

Abstract
As the use of AI-generated content grows, it becomes imperative to recognize which data is human-developed and which is not. AI-generated content comes in several modalities such as deepfakes, text and images. This article proposes techniques that can be used to tackle this problem. To identify deepfakes we can take advantage of characteristics that make us human: blood circulation, human emotions and winks among other things. Text recognition takes a different approach, using a combination of large-scale language models, style analysis, and visual analysis. The generated images can be recognized by analyzing the pixels and common colors and patterns. It can be concluded that AI-generated content is the future, and it is difficult to develop a model that can identify it with 100\% accuracy. Validating content before submitting it and using it responsibly are the steps we should take to adapt to a world where both types of content coexist.
Structural characterization of SLYM - a 4th meningeal membrane
Authors: Plá Virginia , Bitsika Styliani , Giannetto Michael , Ladron-de-Guevara Antonio , Gahn-Martinez Daniel , Mori Yuki , Nedergaard Maiken , Møllgård Kjeld 
Published: October 2023

Abstract
Traditionally, the meninges are described as 3 distinct layers, dura, arachnoid and pia. Yet, the classification of the connective meningeal membranes surrounding the brain is based on postmortem macroscopic examination. Ultrastructural and single cell transcriptome analyses have documented that the 3 meningeal layers can be subdivided into several distinct layers based on cellular characteristics. We here re-examined the existence of a 4th meningeal membrane, Subarachnoid Lymphatic-like Membrane or SLYM in Prox1-eGFP reporter mice. Imaging of freshly resected whole brains showed that SLYM covers the entire brain and brain stem and forms a roof shielding the subarachnoid cerebrospinal fluid (CSF)-filled cisterns and the pia-adjacent vasculature. Thus, SLYM is strategically positioned to facilitate periarterial influx of freshly produced CSF and thereby support unidirectional glymphatic CSF transport. Histological analysis showed that, in spinal cord and parts of dorsal cortex, SLYM fused with the arachnoid barrier layer, while in the basal brain stem typically formed a 1–3 cell layered membrane subdividing the subarachnoid space into two compartments. However, great care should be taken when interpreting the organization of the delicate leptomeningeal membranes in tissue sections. We show that hyperosmotic fixatives dehydrate the tissue with the risk of shrinkage and dislocation of these fragile membranes in postmortem preparations.
Towards a comprehensive COVID-19 non-pharmaceutical interventions’ index for the province of Quebec.
Authors: Mamri Asma , Pereira Camila Correa Matias , Gilani Vahid Najafi Moghaddam , Batomen Brice , Brown Thomas Gordon , Cloutier Marie-Soleil , Ouimet Marie Claude , Paquet Cynthia , Giroux Claude , Tremblay Joël , Turmel Émilie , Vanlaar Ward , Nazif-Munoz Jose Ignacio 
Published: October 2023

Abstract

Objectives: The primary objective of this project was to develop a comprehensive COVID-19 non-pharmaceutical interventions’ index for the province of Quebec (QCnPI-Index), Canada. The resulting and open access database systematically categorizes, multiple non-pharmaceutical interventions implemented to mitigate the spread of COVID-19 in the 17 administrative regions (AR) of the province of Quebec in the form of an index.
Data description: Data represent interventions and groups of interventions implemented during the COVID-19 period in Quebec. They are a compilation of policies, guidelines, and governmental interventions related to COVID-19, considering temporal and geographical dimensions. Data were collected, from March 2020 to July 2022, for all 17 ARs of Quebec using dates and ARs as unit of analysis. Data were collected and coded by an interdisciplinary research team.
Contribution: This quantitative instrument offers the necessary granularity for nuanced spatial and temporal studies within the province of Quebec, using AR, for instance, as unit of analysis. With this database, pre-, during-, and post-COVID periods can thus be better analyzed. Additionally, the innovative methodologies employed for data collection, coding, and weighting offer valuable insights that may have broader applications in public health, epidemiology, and other research domains. The QCnPI-Index could be instrumental for public health, epidemiology, and transportation researchers investigating the multifaceted impacts of non-pharmaceutical interventions on various societal domains, such as road safety, alcohol and cannabis consumption, and/or mental health, in the province of Quebec.
Microfiber coating for propeller noise reduction
Authors: Hasegawa Mitsugu , Sakaue Hirotaka 
Published: October 2023

Abstract
The popularity of small aerial vehicles has dramatically increased in recent years and propeller noise from such vehicles is a public health concern. Further advancement and utilization of small aerial vehicles requires a substantial focus on noise reduction. Surface and coating technology are applied in a variety of ways to address this engineering challenge. This study investigates a microfiber coating as a passive means for reducing propeller noise. The microfiber coating is comprised of a fibrous surface and has been previously shown to be a passive mean for reducing drag on a circular cylinder. To begin testing the efficacy of the microfiber coating for propeller noise reduction, microfiber-coated strips are placed at different spanwise locations on propeller blades. The sound pressure level produced by the rotating propeller is measured using a sound-level meter. The microfiber-coated propeller exhibited a lower sound pressure level than that of the uncoated propeller. At a Reynolds number of 7.4 × 104 based on the chord at the 75% spanwise station of the propeller blade, the microfiber-coated propeller achieved a noise reduction of up to 1.6 dBA compared to that of the uncoated propeller. The microfiber coating is effective in reducing broadband noise associated with the interaction of the turbulent boundary layer with the trailing edge as well as vortex shedding associated with laminar boundary layer separation. It is found that the noise-reduction performance is a function of the spanwise location of the microfiber-coated strips.
Causal relationship between tea intake and bone mineral density at different ages: a Mendelian randomization study
Authors: Shen Ting , Guan Yining , Cai Jiaru , Jin Yizhou , Jiang Yixin , Lin Jiaying , Yan Chenxin , Sun Jiawei 
Published: October 2023

Abstract

Background:
Based on research evidence, bone mineral density(BMD) is closely related to the occurrence of osteoporosis and fractures, and tea intake in daily diet has an important impact on bone density changes. However, the inherent relationship between them is not clear. We adopted a two-sample Mendelian randomization (MR) method to evaluate the causal effect of tea intake on bone density and further explore whether it has specificity in different age groups.
Methods：
Analyzed meta-data from genome-wide association studies (GWAS) on tea consumption. Used single-nucleotide polymorphisms (SNPs) closely associated with tea consumption as instrumental variables (IVs) for a two-sample Mendelian randomization, the MR-Egger, IVW, Weighted median, Weighted mode methods were used to assess the causal analysis of tea intake between BMD at different ages.
Result:
Including 31 single nucleotide polymorphisms as instrumental variables. According to the results of inverse variance weighting (IVW), we found that tea intake had a positive causal effect on systemic BMD, but different age groups (0-15 years; 15-30 years; 30-45 years; 45-60 years; over 60 years) showed positive causality only in the 45-60 age range, with no significant statistical effect in other age groups. Evidence suggests that there is no genetic pleiotropic effect of tea intake on the causal effect of systemic BMD or between the five age groups (P> 0.05). In the IVW method, Cochran Q statistic and MR-Egger regression were used to calculate heterogeneity, and P > 0.05 indicates the absence of significant heterogeneity.
Conclusion:
The results of MR analysis showed that tea intake had a positive causal relationship on total body BMD, while in different age groups, tea intake only positively affected BMD in the 45–60 age group. This means that tea is beneficial for maintaining or increasing BMD in this age group, and may reduce the risk of osteoporosis and fracture.
Randomized Placebo-Controlled Phase 2 Study of Extended-Release Ketamine Tablets (R-107) for Treatment-Resistant Depression – the BEDROC Study
Authors: Glue Paul , Glue Paul , Loo Colleen , Fam Johnson , Lane Hsien-Yuan , Young Allan , Surnam Peter 
Published: October 2023

Abstract

Ketamine has rapid-onset antidepressant activity in patients with treatment-resistant major depression (TRD). The safety and tolerability of racemic ketamine may be improved if given orally, as an extended release tablet (R-107), compared with other routes of administration. In this phase 2 multicentre clinical trial, adult patients with TRD and Montgomery-Asberg Depression Rating Scale (MADRS) scores >20 received open label R-107 tablets 120mg/day for 5 days and were assessed on Day 8 (enrichment phase). On Day 8, responders (MADRS scores <12 and reduction >50%) were randomized on a 1:1:1:1:1 basis to receive double-blind R-107 doses of 30, 60, 120, or 180mg, or placebo, twice weekly for a further 12 weeks. Non-responders on Day 8 exited the study. The primary endpoint was least square mean change in MADRS for each active treatment compared with placebo at 13 weeks, starting with the 180mg dose, using a fixed sequence step-down closed test procedure. Between August 2016 and April 2020, 329 individuals were screened for eligibility, 231 entered the open label enrichment phase (Days 1-8), and 168 responders were randomized to double-blind treatment. The primary objective was met; the least square mean difference of MADRS score for the 180mg tablet group and placebo was -6.1 (95% CI 1.0-11.16, p=0·019) at 13 weeks. Relapse rates during double-blind treatment showed a dose-response, from 70.6% for placebo, to 42.9% for 180mg. Tolerability was excellent, with no changes in blood pressure, minimal reports of sedation, and minimal dissociation. The most common adverse events were headache, dizziness and anxiety. During the randomised phase of the study most patient dosing occurred at home. R-107 tablets were effective, safe and well-tolerated in a patient population with TRD, enriched for initial response to R-107 tablets. Clinical Trial Registration ACTRN12618001042235.
Flemish critical care nurses’ experiences regarding the influence of work-related demands on their health: A descriptive interpretive qualitative study
Authors: Billiau Lukas , Bolliger Larissa , Clays Els , Eeckloo Kristof , Ketels Margo 
Published: October 2023

Abstract
Background: Critical care nurses (CCNs) around the globe face other health challenges compared to their peers in general hospital nursing. Moreover, the nursing workforce grapples with persistent staffing shortages. In light of these circumstances, developing a sustainable work environment is imperative to retain the current nursing workforce. Consequently, this study aimed to gain insight into the recalled experiences of CCNs in dealing with the physical and psychosocial influences of work-related demands on their health while examining the environments in which they operate. The second aim was to explore the complex social and psychological processes through which CCNs navigate these work-related demands across various CCN wards.
Methods: A qualitative study following Thorne’s interpretive descriptive approach was conducted. From October 2022 to April 2023, six focus groups were organised. Data from a diverse sample of 27 Flemish CCNs engaged in physically demanding roles from three CCN wards were collected. The Qualitative Analysis Guide of Leuven was applied to support the constant comparison process.
Results: CCNs reported being exposed to occupational physical activity, emotional, quantitative, and cognitive work-related demands, adverse patient behaviour, and poor working time quality. Exposure to these work-related demands was perceived as harmful, potentially resulting in physical, mental, and psychosomatic strain, as well as an increased turnover intention. In response to these demands, CCNs employed various strategies for mitigation, including seeking social support, exerting control over their work, utilising appropriate equipment, recognising rewards, and engaging in leisure-time physical activity.
Conclusions: CCNs’ health is challenged by work-related demands that are not entirely covered by the traditional quantitative frameworks used in research on psychologically healthy work. Therefore, future studies should focus on improving such frameworks by exploring the role of psychosocial and organisational factors in more detail. This study has important implications for workplace health promotion with a view on preventing work absenteeism and drop-out in the long run, as it offers strong arguments to promote sufficient risk management strategies, schedule flexibility, uninterrupted off-job recovery time, and positive management prolonged well-being and sustainable careers of the CCN workforce.