bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect Modification of Pregnancy Mother's Class on Parent Readiness on Primigravida at Upt Puskesmas Beber, Cirebon Regency in 2022
Authors: Suratmi Suratmi , Mariani Nina Nirmaya 
Published: November 2023

Becoming a parent is a very important phase of life for humans and has a big impact if one goes wrong in the process. Therefore, various efforts are needed so that every couple has the readiness to become parents. On the other hand, Class for Pregnant Women (KIH) is a program aimed at making mothers aware of all information and as a means to learn together about health for pregnant women, in the form of face-to-face in groups. It is necessary to modify the KIH in order to prepare to become a maximum family. The study was conducted at Beber Health Center, Cirebon Regency from March to December 2022 with a quasi-experimental quantitative study in one group (non-random pre-test and post-test without control group design). Sampling was carried out by Total Sampling on the mother of the first child as many as 28 respondents. The activity was carried out 4 times in an attractive manner and got the results that most of the respondents were aged 20-35 years, had elementary school education, did not work, the average score of readiness before the intervention was 34.29 (± 5,437) and before the intervention was 41.67 (± 4,977). there is a difference in the average readiness as a parent before and before the intervention with a p value of 0.001. Based on this research, the Maternity Class with modifications needs to be developed and implemented for mothers of the first child to increase readiness as parentKeywords: Modification, KIH, Being, Parent
Prospects of using gene therapy and nanotechnologies for the treatment of neurodegenerative diseases
Authors: Rudenko Ye.V. , Sholomon S.M. 
Published: November 2023

In the literature review, an attempt is made to systematize scientific literature regarding the possible prospects of applying gene therapy and nanotechnologies for the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. It provides a brief description of the likely etiology and pathogenesis of these diseases and offers examples of potential gene targets for therapeutic interventions. The review lists the shortcomings of traditional treatment strategies for neurodegenerative diseases, including typical obstacles related to drug delivery pathways, overcoming the blood-brain barrier, toxicity, and more. It describes the prospects of using nanotechnologies as technical tools for modifying various structures at the molecular level to achieve desired characteristics. In particular, nanotechnologies are described as means that have the potential to assist in the diagnosis and treatment of neurodegenerative diseases, facilitate drug delivery to the central nervous system (CNS), and enhance their effectiveness. The possibility of using nanocomplexes, manufactured using various modern technologies, is also considered, including a focus on metallic, inorganic, polymeric, lipid nanoparticles, and more. The review also outlines the prospects of gene therapy, its potential for treating disorders of the nervous system through the delivery of genetic material to produce therapeutic molecules. In the context of gene therapy, special emphasis is placed on CRISPR/Cas9 technology, which has been introduced for gene editing in eukaryotic cells and is considered an economically efficient and promising method. Thus, this literature review is focused on the application of nanotechnologies and gene therapy for the treatment of neurodegenerative diseases.
Dysfunction of the hemostasis systemin patients with multiple sclerosis and coronavirus infection
Authors: Melnyk V.S. , Sholomon S.M. 
Published: November 2023

Multiple sclerosis is a chronic demyelinating disease of the central nervous system, accompanied by a disruption of the blood-brain barrier, the development of neuroinflammation, demyelination, and neurodegeneration. The coronavirus infection pandemic can manifest symptoms affecting the nervous system and exacerbate existing neurological pathology. The SARS-CoV-2 virus disrupts the integrity of the blood-brain barrier through the massive release of cytokines and proteases, activating microglia and oligodendrocytes, which initiate neuroinflammatory and neurodegenerative processes. Experimental studies have demonstrated that coronaviruses can lead to demyelination and provoke exacerbations of multiple sclerosis in affected women. Dysfunction of cerebral endothelium and platelet activation plays a crucial role both in the pathophysiology of multiple sclerosis and coronavirus infection, linking disorders of the primary hemostasis system with neuroinflammation. A close connection has been established between coagulation, inflammation, and immune reactions that occur within the vascular system. There is a hypothesis that coagulation activation at the neurovascular level may contribute to the emergence and maintenance of inflammatory reactions characteristic of multiple sclerosis pathogenesis. This occurs as a result of fibrinogen penetration through the compromised blood-brain barrier, which correlates with areas of axonal damage and results in the unwanted activation of microglia and macrophages, intensifying neuroinflammation. Dysfunction of the hemostasis system in patients with multiple sclerosis and COVID-19 can lead to a worsening of the disease course, deterioration of neurological status, and unsatisfactory treatment outcomes.
The role of ultrasound screening in the diagnosis of small vessel disease
Authors: Khramtsov D.M. , Vikarenko M.S. 
Published: November 2023

Objective — to assess the diagnostic value of ultrasound screening in small vessel disease.
Materials and methods. The study was carried out on the clinical bases of the Department of Therapeutic Disciplines of Black Sea National University named after Petro Mohyla (Odesa, Mykolaiv) from 2020 to 2022. A high-field 1.5 T MRI (Siemens Symphony, Germany) was used for verification. The presence of focal brain white matter lesions was assessed on axial T2-weighted and FLAIR sequences using the Fazekas, Scheltens, and Koedam scales. Cognitive functions were assessed using the MMSE scale. All patients underwent Doppler imaging of cerebral vessels using a Toshiba Aplio 500 device (Japan). As a control, 30 individuals of the same age without signs of SVD were examined. Statistical processing was carried out using methods of dispersion and correlation analysis with Statistica 14.0 software (TIBCO, USA).
Results. All patients in the main group exhibited a moderate decrease in cognitive abilities, with an MMSE score of (23.5 ± 0.4) points (in the control group — (26.7 ± 0.5) points, p < 0.05). When evaluating the results of the MRI study, phenomena of leukoencephalopathy were observed in all patients. In 9 (19.6 %) patients, stage I according to Fazekas was determined, in 22 (47.8 %) — stage II, and in 15 (32.6 %) — stage III according to Fazekas. For comparison, in the control group, only 4 (13.3 %) had minimal signs of leukoencephalopathy (grade I according to Fazekas). Atrophy of the temporal cortex of the 1st degree according to Scheltens was detected in 14 (30.4 %) patients in the main group, and atrophy of the parietal cortex of the 1st degree according to Koedam was observed in 8 (17.4 %). During ultrasound examination, signs of subclinical carotid artery lesions were found in 28 (69.9 %) patients with SVD and in 5 (16.7 %) individuals in the control group. When assessing the blood flow in the middle cerebral artery of all patients with SVD, an increase in the Gosling index to 1.15 ± 0.03 and Pourcelot index to 0.66 ± 0.03 was observed. The value of the pulsatility index correlated with the degree of damage according to Fazekas (r = 0.68) and age (r = 0.71), and to a lesser extent with the severity of atrophy of the temporal and parietal cortex (r = 0.35 and r = 0.33). In the control group, the average values of the pulsatility index were 0.79 ± 0.03 (p < 0.001), and the resistance index was 0.57 ± 0.03. When assessing the diagnostic value of the Dopplerometric method, it was established that its sensitivity is 0.96, and specificity is 0.85 (J = 0.81).
Conclusions. Cerebral vascular Doppler ultrasound has a high diagnostic value for detecting diseases of small vessels and can be used to select candidates for neuroimaging verification of SVD.
Pemanfaatan Tumbuhan Perumpung Menjadi Sedotan Alami di Desa Lampuyang
Authors: Jamaludin Mohammad , Andani Tiya , Hapipah Nor , Ningsih Ermi Widia , Rizali M. , Aulia Madinatul , Al-Fitri Aqsa , Abdyansyah Hermawan , Erisya Natasya , Cyntia Herliani , Rahmat Meidi 
Published: November 2023

Pencemaran lingkungan yang disebabkan oleh sampah plastik menjadi permasalahan utama yang dihadapi oleh masyarakat kota dan desa di seluruh wilayah Indonesia. Berbagai upaya telah dilakukan untuk mengurangi permasalahan tersebut, salah satunya dengan mengganti penggunaan sedotan plastik menjadi sedotan alami berbahan dasar tumbuhan perumpung.Â Pengabdian ini bertujuan mengurangi jumlah penggunaan sedotan plastik yang telah banyak mencemari lingkungan dan meningkatkan keterampilan mitra dalam mengolah sedotan alami (berbahan tanaman perumpung) menjadi produk bernilai ekonomi. Pengolahan sedotan alami ini diharapkan dapat membantu meningkatkan perekonomian masyarakat desa Lampuyang yang bermata pencaharian sebagai petani dan juga nelayan. Kegiatan diikuti oleh beberapa orang perwakilan dari unsur pemerintahan desa dan masyarakat Desa Lampuyang. Kegiatan dilakukan melalui beberapa tahapan, yaitu: (1) persiapan awal kegiatan dengan mencari bahan utama sedotan alami yaitu tanaman liar alang-alang (perumpung), (2) pengolahan sedotan alami hingga menjadi suatu produk yang bernilai ekonomis, (3) pemasaran produk yang telah dihasilkan dalam hal ini sedotan alami, dan (4) evaluasi dengan mewawancarai pemerintahan desa Lampuyang terkait progress kegiatan pengolahan sedotan alami. Keberhasilan kegiatan pengabdian ini ditunjukkan dengan berkurangnya jumlah penggunaan sampah plastik di Desa Lampuyang, meningkatnya keterampilan mitra dalam mengolah sedotan alami dari tanaman perumpung bernilai ekonomi sekaligus membuka lapangan pekerjaan baru bagi masyarakat desa.
Pelatihan Pengembangan Keterampilan Membuat Soal Berbasis Teka-Teki Silang Online Bagi Calon Guru
Authors: Murniasih Tatik Retno , Farida Nur , Rahaju Rahaju , Suwanti Vivi , Patridina Esa P.B.G.G. , Faizah Siti , Rahmi Ainu , Arifin Samsul , Kristanto Albert 
Published: November 2023

Teka-teki silang (TTS) online merupakan salah satu alternatif media pembelajaran. Sebagian besar calon guru belum terampil membuat soal numerasi berbasis TTS online. Pemberian soal yang monoton membuat siswa merasa bosan. Tujuan pengabdian ini untuk memberikan pelatihan pembuatan soal TTS online menggunakan software EclipseCrossword bagi 24 orang mahasiswa calon guru matematika di Kota Malang. Â Metode yang digunakanÂ pada pengabdian ini yaitu: diskusi, pelatihan, pendampingan, dan evaluasi kegiatan. Kegiatan pengabdian dilaksanakan sebanyak dua Â pertemuan setiap Sabtu yang diikuti 24 orang peserta. Pertemuan pertama dilaksanakanÂ pembuatan soal dan kunci jawaban numerasi. Pertemuan kedua dilaksanakan praktik pembuatan TTS online dengan software EclipseCrossword. Hasil pengamatan pengabdian menunjukkan adanya peningkatan keterampilan dan ketertarikan calon guru dalam membuat soal TTS online. Hasil angket menunjukkan calon guru merasa puas terhadap pelaksanaan dan menghendaki keberlanjutan program pengabdian.
Edukasi Tentang Perilaku Hidup Bersih dan Sehat Pada Siswa Sekolah Menengah Pertama Negeri 13 Sigi
Authors: Paundanan Matius , Purnamasari Niluh Desy , Kolupe Veni Mornalita , Parmi Parmi , Rikwan Rikwan , Fajrah Sitti , Suriawanto Nelky 
Published: November 2023

Penerapan perilaku hidup bersih dan sehat (PHBS) pada anak sekolah harus diimplementasikan sejak dini sehingga dapat membentuk karakter anak dalam penerapan PHBS khususnya di sekolah. Pelaksana kegiatan adalah dosen bersama mahasiswa Program Studi Kesehatan Masyarakat Sekolah Tinggi Ilmu Kesehatan Indonesia Jaya yang berjumlah 25 orang. Tujuan kegiatan pengabdian kepada masyarakat ini untuk menambah pemahaman siswa tentang PBHS di sekolah. Metode yang digunakan dalam kegiatan pengabdian kepada masyarakat adalah penyuluhan secara langsung kepada siswa. Kegiatan diikuti oleh 70 orang siswa peserta. Kegiatan berjalan dengan lancar dan dapat diselesaikan dengan baik. HasilÂ evaluasiÂ menunjukkan bahwa pemahaman siswa tentang PHBS lebih dari 70%.
Bimbingan Belajar Calistung (Membaca, Menulis Dan Berhitung) Gratis Bagi Siswa Sekolah Dasar
Authors: Silalahi Jojor , Galingging Cikep Kosasih , Hutabarat Lidya Evauli , Hutabarat Debora Sintiya , Sembiring Agustia Raspasuni , Siahaan Rosintan Yorini 
Published: November 2023

Pelaksanaan bimbingan belajar â€œcalistungâ€ (membaca, menulis dan berhitung) bertujuan untuk meningkatkan kompetensi literasi dan numerasi siswa. Kegiatan ini merupakan bagian program pengabdian masyarakat yang dilakukan oleh lima orang mahasiswa bersama satu orang dosen pembimbing lapangan Fakultas Keguruan dan Ilmu Pendidikan Universitas HKBP Nommensen Medan. Metode kegiatan dilakukan dengan memberikan bimbingan belajar gratis setiap harinya Â kepada siswa-siswi kelas satu hingga kelas enam usai jam pelajaran sekolah. Selain bimbingan belajar, kegiatan untuk meningkatkan kreativitas seni siswa juga dilakukan dengan menyelenggarakan latihan minat dan bakat di hari Jumat dan Sabtu. Kegiatan ini dinilai berhasil dengan indikator adanya peningkatan nilai rata-rata posttest dari nilai rata-rata pre-test dan pertunjukan kreativitas siswa yang baik dalam penampilan drama dalam Bahasa Inggris, bernyanyi dan menari tari tradisional pada saat pelaksanaan pentas seni yang diselenggarakan pada hari terakhir kegiatan.
“Perestroika” à la Nigérien: The Reasons for the Military Coup of 2023
Authors: Issaev Leonid M. 
Published: November 2023

The article is devoted to the study of the events that transpired in Niger in July 2023, which led to the overthrow of President Mohamed Bazum by members of his own guard, under the command of Abdrahman Tchiani.
The fieldwork and interview materials that the authors gathered in Niger in September 2023 are used in this article. It is demonstrated that an escalated intra-elite conflict that started to fester as soon as Mohamed Bazum was elected president in 2021 was the cause of the military coup. The opposition, led by the Democratic and Republican Renewal Party and the Niger Democratic Movement for an African Federation, immediately denounced the results of the February 2021 presidential election as being falsified and staged large-scale demonstrations.
Then, in March 2021, before the inauguration in Niger, an unsuccessful coup attempt was made. A disagreement between Mohamed Bazum and his predecessor, Mahamadou Issoufou, inside the ruling Party for Democracy and Socialism may have become apparent by the middle of 2023. The Nigerian security forces, led by Abdrahman Tchiani, the head of the Presidential Guard, and Salifou Modi, the former and current Chief of the General Staff, as well as Abdou Issa, who opposed the current president, spoke the final word.
Improved cosine similarity measures for q-Rung orthopair fuzzy sets
Authors: Ünver Mehmet 
Published: November 2023

In this short correspondence, we introduce some novel cosine similarity measures tailored for \(q\)-rung orthopair fuzzy sets (\(q\)-ROFSs), which capture both the direction and magnitude aspects of fuzzy set representations. Traditional cosine similarity measures focus solely on the direction (cosine of the angle) between vectors, neglecting the crucial information embedded in the lengths of these vectors. To address this limitation, we propose some improved cosine similarity measures, which extend the conventional cosine similarity by incorporating a length difference control term. These measures not only outperform traditional cosine similarity measures for \(q\)-ROFSs but also improve the existing cosine similarity measures for intuitionistic fuzzy sets and Pythagorean fuzzy sets, making them a valuable addition to the fuzzy set cosine similarity measures. These similarity measures are defined as the average and Choquet integral of two components: the first component, \(\text{Cos}_{A,B}(x_{j})\), quantifies the cosine similarity between \(q\)-ROFS \(A\) and \(B\) at each element \(x_{j}\). The second component, \(L_{A,B}(x_{j})\), represents the difference in lengths between the vector representations of \(A\) and \(B\) at the same element \(x_{j}\). This length-difference term ensures that the measures are sensitive to variations in both direction and magnitude, making them particularly suitable for applications where both aspects are significant. The measure derived through the Choquet integral also takes into account the interaction among the elements, thereby enhancing the sensitivity of solutions in various applications.
TEKANAN PADA PENCETAKAN EMPING MELINJO MENGGUNAKAN MESIN PENCETAK SISTEM PNEUMATIK
Authors: Sugiyanto Bambang , Rahman Abd , Bahri Nisfan , Supriyanto  , Sebayang Abdi Hanra 
Published: November 2023

ABSTRACT
Melinjo chip is a typical Indonesian snack, which is high in nutrition, has a distinctive taste and is liked by many people. The process of producing melinjo chip manually requires a long time, long process, so the productivity is very low, it requires innovation in the procurement and development of equipment/machines for producing melinjo chip so that it can help the production process, lighten the burden on workers/craftsmen and increase the productivity of melinjo chip craftsmen. The research created a prototype of a melinjo chip molding machine, with the application of a pneumatic system to move the pressing tool while providing adequate thrust to flatten the melinjo core seeds in the melinjo chip production process which can replace manual work, the stages involved are designing the machine prototype construction, building machine prototype, tested the machine prototype, the test results showed that to get melinjo chips with a thickness of one millimeter, a pressure of six bars was needed, with four melinjos every once mold and the entire system on the machine could function properly.
Keywords: Melinjo chip, pneumatic system, moulding machine

Emping Melinjo adalah salah satu makanan ringan khas Indonesia, yang memiliki gizi tinggi, memiliki rasa yang khas dan disukai oleh banyak masyarakat. Proses produksi emping melinjo secara manual membutuhkan proses panjang, lama, sehingga produktifitasnya sangat rendah, perlu inovasi pengadaan dan pengembangan alat/mesin pencetak emping melinjo sehingga dapat membantu proses produksi, meringankan beban pekerja/perajin dan meningkatkan produktivitas perajin emping melinjo. Penelitian menciptakan protipe mesin pencetak emping melinjo, dengan aplikasi sistem pneumatik untuk menggerakkan alat penekan sekaligus memberikan gaya dorong yang memadai untuk memipihkan biji inti melinjo dalam proses produksi emping melinjo yang dapat menggantikan pekerjaan manual, tahapan-tahapan yang dilalui adalah merancang konstruksi prototipe mesin, membangun prototipe mesin, menguji prototipe mesin, hasil pengujian didapatkan bahwa untuk mendapatkan emping melinjo dengan tebal satu milimeter dibutuhkan tekanan sebesar enam bar, dengan empat biji melinjo setiap sekali cetak dan seluruh sistem pada mesin dapat berfungsi dengan baik.

Kata Kunci: Emping melinjo, sistem pneumatik, mesin pencetak.
Pengaruh Waktu, Jumlah Yeast, dan Konsentrasi Substrat Pada Fermentasi Limbah Kulit Nanas Menjadi Bioetanol Skala Home Industry
Authors: Chamidy Harita Nurwahyu , Saripudin Saripudin , Permanasari Ayu Ratna 
Published: November 2023

Kulit nanas merupakan limbah yang mengandung glukosa sehingga dapat dimanfaatkan menjadi bioetanol. Kulit nanas selama ini belum banyak dimanfaatkan sehingga tidak memiliki nilai ekonomis. Â Penelitian ini bertujuan memanfaatkan limbah kulit nanas untuk menjadi bioetanol dengan cara fermentasi, dimana proses fermentasi akan dilanjutkan dengan distilasi. Fokus penelitian ini berada pada variasi konsentrasi gula substrat karena kenyataannya limbah kulit nanas di lingkungan memiliki konsentrasi gula yang berbeda-beda. Penelitian ini dilakukan dalam skala home industry dengan proses yang dibuat semirip mungkin dengan proses pembuatan bioetanol yang dilakukan pada industri besar. Kapasitas produksi 5 L dengan substrat berupa air perasan kulit nanas. Variasi substrat yang digunakan adalah 3, 4, 5, dan 6 Â°Bx dengan waktu fermentasi 3 dan 5 hari. Mikroorganisme yang digunakan adalah yeast kering dengan variasi berat 5, 10, dan 15 g. Nutrien berupa pupuk NPK dan Urea dengan kadar 0,5% (b/v). Media fermentasi tidak disterilisasi untuk menyamakan dengan kondisi proses yang ada di industri bioetanol. Hasil fermentasi didistilasi pada suhu 83 Â°C selama kurang lebih 2 jam. Hasil terbaik diperoleh pada variasi konsentrasi substrat dengan kadar gula 6 Â°Bx, berat yeast 15 g, yaitu kadar alkohol setelah fermentasi sebesar 9 % dan hasil distilasi diperoleh kadar alkohol 45% sebanyak 170 ml.
Interview with David Bobier (Dispatch)
Authors: Bobier David , Ignagni Esther 
Published: November 2023

<p>Esther Ignagni, a researcher with the <em>Cripping the Arts</em> project, interviewed disability artist and cultural producer David Bobier about his many years of experience with “cripping the arts.” This is an excerpt from their interview. Bobier subsequently added a few comments to the interview transcript to contextualize his thoughts within the current moment of the pandemic. </p>
Validity and Reliability of a Thai Behavioral and Emotional Screening Tool for Children with Enuresis (TBEST-E)
Authors: Manomaivong Varis , Wannapaschaiyong Prakasit , Sirisakpanit Sudarat , Kantasorn Jeeranan , Tarugsa Jariya , Piyaphanee Nuntawan , Chantaratin Sasitorn 
Published: November 2023

Objective: Psychological comorbidity in children with enuresis is common and its screening is recommended. A brief validated screening instrument is needed for a busy medical practice. This study focused on the development of the Thai Behavioral and Emotional Screening Tool for children with Enuresis (TBEST-E) and aimed to examine its psychometric properties.
Materials and Methods: Using the Short Screening Instrument for Psychological Problems in Enuresis (SSIPPE) as a template, the 15-item with a yes/no answer format of the TBEST-E was developed for the screening of emotional problems (7 items), attention and hyperactivity/impulsivity problems (3 items each), and oppositional defiant symptoms (2 items). The parents of the children with enuresis completed the TBEST-E and the behavioral rating scale “Thai Youth Checklist” (TYC). The optimal cut-off for further assessment, the sensitivity, and the specificity the TBEST-E were identified using receiver operating characteristic (ROC) curves.
Results: After an adaptation following comments from three child psychiatrists, the TBEST-E showed a content validity of 0.9, an internal consistency of 0.71. A total of 33 children with enuresis (median age = 9, interquartile range = 6.5-11 years) were recruited. Further assessment was indicated when one of the following occurred; at least 3 emotional problems; 3 attention problems; or 2 hyperactivity/impulsivity together with 2 oppositional defiant symptoms. The overall sensitivity and specificity were 0.88 and 0.71 respectively with the accuracy of 0.84 (95% CI = 0.68-0.95).
Conclusion: The TBEST-E is time-efficient and has acceptable psychometric properties in early detection of common psychological problems in children with enuresis.