bluuebunny/crossref_metadata_2025_split huggingface dataset:
Displacement of mining vibrating screen obtained from acceleration based on improved S–G filter
Authors: Xiao Linjing , Lu Hao , Yan Fangping 
Published: February 2024

AbstractVibration displacement is one of the key parameters in fault diagnosis of vibrating screens. Monitoring of acceleration signals of vibrating screens can be disturbed due to various factors such as on-site working conditions and equipment. In order to obtain accurate displacement signals of vibrating screen, the method for converting vibration acceleration to displacement based on improved Savitzky–Golay (S–G) filter is proposed. The Particle Swarm Optimization (PSO) algorithm is used to optimize the window length of the S–G filter with the fixed polynomial. The filters are cascaded to denoise the signals multiple times. The reasonable regularization parameter of the Smoothed Prior Approach (SPA) is calculated to remove the trend item from the acceleration signals. The vibration displacement is obtained by integrating the preprocessed acceleration data in the frequency domain. The results demonstrate that the objectivity of parameter selection of filter is improved, and the denoising effect is significant. The filtering effect of the filter is further improved after cascading. It becomes better as the number of stages of cascade increases. The vibration displacement can be obtained accurately by the proposed method. The vibration test platform is built to verify the correctness of the method.
Quantitate evaluation of photogrammetry with CT scanning for orbital defect
Authors: Beri Arushi , Pisulkar Sweta Kale , Paikrao Balaji , Bagde Ashutosh , Bansod Akansha , Shrivastava Akshay , Jain Ritul 
Published: February 2024

AbstractFacial deformities can be caused by cancer, tumours, trauma, infections, congenital or acquired defects and may lead to alteration in basic functions such as communication, breathing, and mastication and aesthetic thereby affecting quality of life. Traditional processes for manufacturing maxillofacial prostheses involve complicated, time-consuming and tedious processes for the patient and the operator. Impression of the defect area, which is the one of the crucial step in fabrication of prosthesis, is the longest and most difficult process as it requires a long contact with the patient. The digital revolution is now changing the landscape of prosthetic production and making the impression making procedure simpler. Digital technology reduces patient chair side time by providing more accurate display data in less time (3–5 min) than traditional methods. Digital impressions eliminate the need for bulky impression materials and provide a more comfortable patient experience.
Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape
Authors: Yang Kanglong , Chen Guanglin , Yu Fan , Fang Xianyang , Zhang Jiahai , Zhang Zhiyong , Shi Yunyu , Zhang Liang 
Published: February 2024

AbstractImmunotherapy, including immune checkpoint inhibitors and adoptive cell transfer, has obtained great progress, but their efficiencies vary among patients due to the genetic and epigenetic differences. Human MEX3B (hMEX3B) protein is an RNA-binding protein that contains two KH domains at the N-terminus and a RING domain at its C-terminus, which has the activity of E3 ubiquitin ligase and is essential for RNA degradation. Current evidence suggests that hMEX3B is involved in many important biological processes, including tumor immune evasion and HLA-A regulation, but the sequence of substrate RNA recognized by hMEX3B and the functional molecular mechanisms are unclear. Here, we first screened the optimized hMEX3B binding sequence on the HLA-A mRNA and reported that the two tandem KH domains can bind with their substrate one hundred times more than the individual KH domains. We systematically investigated the binding characteristics between the two KH domains and their RNA substrates by nuclear magnetic resonance (NMR). Based on this information and the small-angle X-ray scattering (SAXS) data, we used molecular dynamics simulations to obtain structural models of KH domains in complex with their corresponding RNAs. By analyzing the models, we noticed that on the KH domains’ variable loops, there were two pairs of threonines and arginines that can disrupt the recognition of the RNA completely, and this influence had also been verified both in vitro and in vivo. Finally, we presented a functional model of the hMEX3B protein, which indicated that hMEX3B regulated the degradation of its substrate mRNAs in many biological processes. Taken together, our research illustrated how the hMEX3B protein played a key role in translation inhibition during the immune response to tumor cells and provided an idea and a lead for the study of the molecular mechanism and function of other MEX3 family proteins.
Self-locking Kirigami surfaces via controlled stretching
Authors: Zhang Qian , Pan Ning , Liu Shuangbo , Feng Jian , Cai Jianguo 
Published: February 2024

AbstractKirigami provides a powerful strategy to transform two-dimensional elements into complex three-dimensional functional structures with lengths ranging from nanoscale to microscale and macroscale. The stability and programmability of forming three-dimensional structures through mechanical actuation, whether external or self-balancing, are crucial. Here, we offer a system that performs the 2D to 3D transformation through sequential in-plane tension and release. As a result, the 3D state is obtained by out-plane popping and rotation and shows a self-locking behavior. The range of geometric parameters for kirigami elements with different stability properties is determined theoretically. The in-plane tension conditions are also calculated to break the transition point of the forming process. The horizontal and vertical modular array analysis demonstrates the scalability and programmability from the self-locking elements to the Kirigami surfaces. We expect that the kirigami pattern and design approach will serve for innovative systems, including tunable antennas, flexible electronics, and medical devices.
Device-compatible ultra-high-order quantum noise stream cipher based on delta-sigma modulator and optical chaos
Authors: Luo Hanwen , Zhang Ziheng , Dai Longquan , Zhong Linsheng , Yang Qi , Deng Lei , Liu Deming , Dai Xiaoxiao , Gao Xiaojing , Cheng Mengfan 
Published: February 2024

AbstractData security is a key feature of future communications networks. Physical layer introduces rich physical mechanisms to increase the complexity of deciphering and provides extensive protection, but faces challenges in compatibility with commercial systems. Quantum noise stream cipher (QNSC) has been proposed as a promising solution to overcome this problem by fusing the stream cryptography regime with the quantum noise masking physical mechanism. However, it has limitations in terms of digital to analog conversion and clock data synchronization of ultra-high-order ciphertext as well as flexible control of masking noise. Here we report a 147.9-Gbps device-compatible quadrature amplitude modulation (QAM) QNSC secure scheme over 75-km fiber. Thanks to delta-sigma modulator, the transmission of 220 × 220-order QAM-QNSC signal are established through the low-order digital signal. We develop a theoretical model for flexibly regulating the transmission rate and security performance. Broadband optical chaos introduces true randomness and acts on the masking noise.
A Li–O2/CO2 battery based on bio-inspired engineering of the Bi2S3/PVP cathode
Authors: Gao Song , Li Siqi , Han Miao , E. Yuanlong , Liu Wanqiang , Jia Hongsheng , Wang Fang 
Published: February 2024

1. A PVP/Bi2S3 is used as the cathode of Li–CO2 battery for the first time. 2. The introduction of PVP not only increases the generation of S vacancy, but also improves the electronic conductivity of Bi2S3. 3. The proposed PVP/Bi2S3 cathode can also be applied to Li–O2 and Li–CO2 battery systems.
A novel multi‐slice electromagnetic field‐circuit coupling method for transient computation of long‐distance gas‐insulated transmission lines
Authors: Cheng Shucan , Zhao Yanpu , Xie Kejia , Hu Bin 
Published: February 2024

AbstractAccurate calculation of short‐circuit electromagnetic force is crucial for both mechanical strength check and the optimal design of gas‐insulated transmission lines (GIL). Since the full 3D numerical simulation method is highly time‐consuming, a novel lightweight 2D multi‐slice electromagnetic field‐circuit coupled method for computing transient electromagnetic force is proposed, where appropriate port voltage degrees of freedom (DoFs) are introduced for the solid GIL conductor terminals. When the transient magnetic field equations are combined with the constraint equations of circuit part, including nodal voltage and loop current DoFs, a direct field‐circuit coupling scheme is thus derived. The proposed method can simultaneously consider the effect of interphase‐shunts and ground wires, as well as the skin effect and proximity effect. It can accurately capture the transient electromagnetic characteristics of GIL spanning from several to tens of kilometers under different short‐circuit conditions. The transient electromagnetic forces, as well as the induced voltages and currents of the enclosure, are analysed by the proposed method for both single‐phase and three‐phase enclosed GIL under various short‐circuit conditions. The proposed method has the advantages of high accuracy and lightweight computational cost, and thus it is also suitable for conducting important simulation tasks such as mechanical strength checks during the design optimisation phase of long‐distance GIL.
Quantum computer based feature selection in machine learning
Authors: Hellstern Gerhard , Dehn Vanessa , Zaefferer Martin 
Published: February 2024

AbstractThe problem of selecting an appropriate number of features in supervised learning problems is investigated. Starting with common methods in machine learning, the feature selection task is treated as a quadratic unconstrained optimisation problem (QUBO), which can be tackled with classical numerical methods as well as within a quantum computing framework. The different results in small problem instances are compared. According to the results of the authors’ study, whether the QUBO method outperforms other feature selection methods depends on the data set. In an extension to a larger data set with 27 features, the authors compare the convergence behaviour of the QUBO methods via quantum computing with classical stochastic optimisation methods. Due to persisting error rates, the classical stochastic optimisation methods are still superior.
Enger Spinalkanal und osteoligamentäre Verletzung der Halswirbelsäule – operative Therapie
Authors: Kothe Ralph 
Published: February 2024

ZusammenfassungOsteoligamentäre Verletzungen der Halswirbelsäule können gerade bei älteren Patienten mit einer vorbestehenden Enge des Spinalkanales einhergehen. Die Frage der operativen Behandlungsnotwendigkeit ist abhängig von verschiedenen Faktoren. Neben der strukturellen Schädigung der Halswirbelsäule ist das Ausmaß der traumatisch bedingten neurologischen Beeinträchtigung von Bedeutung. Letztere wird nach der ASIA Impairment Scale eingeteilt. Bei der Kombination aus osteoligamentärer Verletzung mit neurologischer Beeinträchtigung (Spinal Cord Injury – SCI) besteht nahezu immer die Indikation zur operativen Behandlung. Eine frühe operative Therapie führt zu besseren klinischen Ergebnissen bei geringerer Komplikationsrate. Die Indikationsstellung zur operativen Behandlung bei osteoligamentärer Verletzung ohne neurologisches Defizit und vorbestehender degenerativer Stenose ist abhängig von der Klassifikation der Verletzung, sowie dem Ausmaß einer eventuell vorbestehenden spondylogenen zervikalen Myelopathie. Diese lässt sich nach dem modifizierten JOA-Score beurteilen. Kommt es nach einem Trauma ohne osteoligamentäre Verletzung bei vorbestehender Stenose zu einer inkompletten neurologischen Schädigung, spricht man von einem Central Cord Syndrom (CCS). Die Indikation zur operativen Behandlung ist in diesem Fall abhängig vom Ausmaß der neurologischen Schädigung. Bei ASIA Grad C wird analog zum SCI mit osteoligamentärer Verletzung zu einer frühzeitigen operativen Behandlung innerhalb von 24 Stunden geraten. Bei einer Schädigung ASIA Grad D kann der weitere neurologische Verlauf zunächst abgewartet werden. Im Falle einer ausbleibenden Besserung ist eine Operation auch noch nach mehr als zwei Wochen möglich.
OF2 # mit sekundärer Sinterung – konservative/operative Therapie
Authors: Herren Christian 
Published: February 2024

ZusammenfassungDie osteoporotische Sinterungsfraktur an der Wirbelsäule stellt die häufigste Frakturform der osteoporotischen Frakturen dar. Aufgrund der demographischen Entwicklung und der mittlerweile sehr hohen Lebenserwartung der geriatrischen Patienten steigt auch die Inzidenz der osteoporotischen Wirbelkörperfrakturen. Basierend auf der Klassifikation der osteoporotischen Frakturen werden fünf unterschiedliche Subgruppen anhand ihrer Morphologie unterschieden. Die OF-Typ 2 Frakturen werden hierbei als kyphotische Deformation mit geringer Hinterwandbeteiligung (<1/5) definiert. Für die Behandlung der osteoporotischen Wirbelkörperfrakturen haben sich mittlerweile unterschiedliche Therapiekonzepte etabliert, die sich jedoch zum Teil deutlich von den Behandlungsstrategien beim jüngeren Patienten unterscheiden. Basis ist hierbei die zu Grunde liegende Osteoporose neben der Frakturbehandlung adäquat zu therapieren. Konservative und operative Therapieansätze können anhand von Behandlungsempfehlungen abgeleitet werden, jedoch fehlen aktuell hochwertige Fallkontrollstudien oder Leitlinien, so dass die Behandlung der osteoporotischen Sinterungsfrakturen häufig auf Expertenmeinungen und Einzelfallentscheidungen basiert.
Change Management für Individuen – ein fiktives Interview mit Prof. Nina Kentucky
Authors: Seemann Ricarda 
Published: February 2024

ZusammenfassungMeine fiktive Gesprächspartnerin Prof. Nina Kentucky1 hat einen fiktiven Beruf: sie ist selbstständige Personal Change Managerin und
begleitet Orthopäd_innen und Unfallchirurg_innen als erfahrene Expertin bei einschneidenden
Veränderungen in Berufs- und Privatleben. Unser Gespräch spiegelt verschiedenste Erfahrungen
aus dem engeren und weiteren Bekanntenkreis wider – und zu einem kleinen Teil vielleicht auch
meine eigenen Erlebnisse. Zur besseren Lesbarkeit wird bei Personenbezeichnungen vornehmlich
das generische Maskulinum verwendet, dies gilt im Sinne der Gleichbehandlung grundsätzlich für
alle Geschlechter.
Synthesis of (5-Iminio-4,5-dihydro-1,3,4-oxadiazol-2-yl)tetrazol-1-ide: A Zwitterionic Compound Containing a Tetrazole Anion as a Promising Blunt Energetic Material
Authors: Liu Yaxin , Lv Meifang , Zhang Guofeng , Ye Zhiwen 
Published: February 2024

Abstract(5-Iminio-4,5-dihydro-1,3,4-oxadiazol-2-yl)tetrazol-1-ide is the first zwitterionic energetic material containing tetrazole as an anion and 1,3,4 oxadiazole as a cation. Its low mechanical sensitivity (IS >40 J, FS >360 N) and high gas volume after detonation at standard temperature and pressure (767.0 dm3/kg) make it a prime example of a novel type of blunt energetic material with promising applications.
Inflammasome-Independent Mechanism of NLRP3 is Critical for Platelet GPIb-IX Function and Thrombosis
Authors: Chen Xiaoyan , Li Jingke , Liu Pu , Zhou Yangfan , Zhang Tongtong , Li Li , Shi Jingqi , Deng Xin , Sheng Yilin , Chen Wei , Wang Di , Hu Hu 
Published: February 2024

Introduction Platelets link thrombosis and inflammation, but how platelets handle the endogenous intraplatelet inflammatory machinery is less well understood. NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) is the central component of the interleukin (IL)-1-producing inflammasome. Elucidating the cell type-specific mechanism of NLRP3 in platelets may improve our understanding of thrombotic diseases.
Methods Ferric chloride-induced mesenteric arteriole thrombosis models, tail bleeding models, and microfluidic whole-blood perfusion were used to study thrombosis and hemostasis. Additionally, we utilized aggregometry, flow cytometry, immunoprecipitation, and western blotting to investigate glycoprotein (GP)Ib-IX-mediated platelet function and signaling.
Results NLRP3−/− mice exhibited severely impaired thrombosis and hemostasis, whereas apoptosis-associated speck-like protein containing a CARD (ASC)−/−, caspase-1−/−, and Nlrp3
A350V/+
CrePF4 mice did not exhibit such changes. NLRP3−/− platelets exhibited reduced adhesion to injured vessel walls and collagen and impaired von Willebrand factor (vWF)-dependent translocation and rolling behavior. NLRP3 deficiency decreased botrocetin-induced platelet aggregation and the phosphorylation of key signaling molecules in the GPIb-IX pathway. Mechanistically, decreased cAMP/PKA activity led to reduced phosphorylation of NLRP3, thereby enabling the interaction between NLRP3 and filamin A. This interaction accelerated the dissociation of filamin A from GPIbα, which allowed a 14–3-3ζ-dependent increase in GPIb-IX affinity to vWF. Finally, platelet NLRP3 was found to largely regulate thrombotic disease models, such as models of stroke and deep vein thrombosis.
Conclusion NLRP3 promoted the function of the major platelet adhesion receptor GPIb-IX without involving NLRP3 inflammasome assembly or IL-1β production.
Clavicle Fracture Site Surgical Contouring: A Case Report
Authors: Cavaliere Annachiara , Cepparulo Vincenzo , Pezone Giuseppe , Schonauer Fabrizio 
Published: February 2024

AbstractClavicle fractures are frequent injuries accounting for approximately 4% of all fractures in adults with about 35% occurring in the shoulder region among which midshaft fractures are the most common (>66%). Nonsurgical management is the treatment of choice for most clavicle fractures; however, poor functional and aesthetic outcomes may result from nonunion, symptomatic malunion, and aesthetic impairment which are the most common complications. A young woman was referred to our clinic for a “Step Deformity” resulting after primary, nonsurgical treatment of a midshaft clavicle fracture. Residual deformity was corrected with a novel simple and little invasive approach. Midshaft clavicle fractures typically only require conservative nonsurgical treatment, nevertheless suboptimal outcomes may occur. Selective osteotomies and fixation are deemed too invasive when only cosmetic impairment of the clavicle contour is present without any functional or sensitive damage and most patients are discouraged from undergoing surgery. Thus far, no specific focus on this topic, nor exploration of possible correction can be found in the published literature. These residual deformities may be very noticeable sometimes and cause psychological distress and social life impairment. Despite no related functional impairment, this deformity should still be addressed, to improve patients' quality of life.
Anti-MAG neuropathy: historical aspects, clinical-pathological correlations, and considerations for future therapeutical trials
Authors: Latov Norman , Brannagan Thomas H. , Sander Howard W. , Gondim Francisco de Assis Aquino 
Published: February 2024

Abstract
Background Patients with anti-MAG neuropathy present with distal demyelinating polyneuropathy, IgM monoclonal gammopathy, and elevated titers of anti-MAG antibodies.
Objective This paper reviews what is known about the clinical presentation, course, pathophysiology, and treatment of anti-MAG neuropathy, with considerations for the design of therapeutic trials.
Methods A literature review of the medical and scientific literature related to anti-MAG neuropathy, and the design of therapeutic clinical trials in peripheral neuropathy.
Results Anti-MAG neuropathy can remain indolent for many years but then enter a progressive phase. Highly elevated antibody titers are diagnostic, but intermediate titers can also occur in chronic inflammatory demyelinating polyneuropathy (CIDP). The peripheral nerves can become inexcitable, thereby masking the demyelinating abnormalities. There is good evidence that the anti-MAG antibodies cause neuropathy. Reduction of the autoantibody concentration by agents that target B-cells was reported to result in clinical improvement in case series and uncontrolled trials, but not in controlled clinical trials, probably due to inadequate trial design.
Conclusion We propose that therapeutic trials for anti-MAG neuropathy include patients with the typical presentation, some degree of weakness, highly elevated anti-MAG antibody titers, and at least one nerve exhibiting demyelinating range abnormalities. Treatment with one or a combination of anti-B-cell agents would aim at reducing the autoantibody concentration by at least 60%. A trial duration of 2 years may be required to show efficacy. The neuropathy impairment score of the lower extremities (NIS-LL) plus the Lower Limb Function (LLF) score would be a suitable primary outcome measure.
Gene-based therapies for neuromuscular disorders
Authors: Zanoteli Edmar , França Marcondes Cavalcante , Marques Wilson 
Published: February 2024

AbstractNeuromuscular diseases (NMD) include a broad group of medical conditions with both acquired and genetic causes. In recent years, important advances have been made in the treatment of genetically caused NMD, and most of these advances are due to the implementation of therapies aimed at gene regulation. Among these therapies, gene replacement, small interfering RNA (siRNA), and antisense antinucleotides are the most promising approaches. More importantly, some of these therapies have already gained regulatory approval or are in the final stages of approval. The review focuses on motor neuron diseases, neuropathies, and Duchenne muscular dystrophy, summarizing the most recent developments in gene-based therapies for these conditions.
The clinical diagnosis of Parkinson's disease
Authors: Munhoz Renato P. , Tumas Vitor , Pedroso José Luiz , Silveira-Moriyama Laura 
Published: February 2024

AbstractAfter more than 200 years since its initial description, the clinical diagnosis of Parkinson's disease (PD) remains an often-challenging endeavor, with broad implications that are fundamental for clinical management. Despite major developments in understanding it's pathogenesis, pathological landmarks, non-motor features and potential paraclinical clues, the most accepted diagnostic criteria remain solidly based on a combination of clinical signs. Here, we review this process, discussing its history, clinical criteria, differential diagnoses, ancillary diagnostic testing, and the role of non-motor and pre-motor signs and symptoms.