bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on roller bearing fault diagnosis method based on flexible dynamic adjustable strategy under data imbalance
Authors: Pan Haiyang , Li Bingxin , Yan Qiuyan , Zheng Jinde 
Published: February 2024

Abstract
In engineering practice, the collection of equipment vibration signals is prone to interference from the external environment, resulting in abnormal data and imbalanced data in different states. Traditional support vector machine, support matrix machine and other methods have advantages in balancing sample classification, but have limitations in obtaining low rank information, making it difficult to perform classification tasks under data imbalance. Therefore, a novel classification method that targets matrices as the input, called flexible dynamic matrix machine (FDMM), is proposed in this paper. First, FDMM establishes a regularization term using a flexible low-rank operator and sparse constrain, which can better take into account matrix structure information. Then, the upper bound of the loss function is truncated, reducing the impact of the loss on the construction of the decision hyperplane. Finally, the recognition performance of imbalanced data is improved by adjusting the game values of different categories of samples through dynamic adjustment function. Experimental results demonstrate that superior classification accuracy and generalization performance can be achieved with the FDMM method when applied to two roller bearing datasets.
DNA nanostructure decoration: a how-to tutorial
Authors: Piantanida Luca , Liddle J Alexander , Hughes William L , Majikes Jacob M 
Published: February 2024

Abstract
DNA Nanotechnology is being applied to multiple research fields. The functionality of DNA nanostructures is significantly enhanced by decorating them with nanoscale moieties including: proteins, metallic nanoparticles, quantum dots, and chromophores. Decoration is a complex process and developing protocols for reliable attachment routinely requires extensive trial and error. Additionally, the granular nature of scientific communication makes it difficult to discern general principles in DNA nanostructure decoration. This tutorial is a guidebook designed to minimize experimental bottlenecks and avoid dead-ends for those wishing to decorate DNA nanostructures. We supplement the reference material on available technical tools and procedures with a conceptual framework required to make efficient and effective decisions in the lab. Together these resources should aid both the novice and the expert to develop and execute a rapid, reliable decoration protocols.
Synthetic CT imaging for PET monitoring in proton therapy: a simulation study
Authors: Moglioni Martina , Carra Pietro , Arezzini Silvia , Belcari Nicola , Bersani Davide , Berti Andrea , Bisogni Maria Giuseppina , Calderisi Marco , Ceppa Ilaria , Cerello Piergiorgio , Ciocca Mario , Ferrero Veronica , Fiorina Elisa , Kraan Aafke Christine , Mazzoni Enrico , Morrocchi Matteo , Pennazio Francesco , Retico Alessandra , Rosso Valeria , Sbolgi Francesca , Vitolo Viviana , Sportelli Giancarlo 
Published: February 2024

Abstract

Objective. This study addresses a fundamental limitation of in-beam positron emission tomography (IB-PET) in proton therapy: the lack of direct anatomical representation in the images it produces. We aim to overcome this shortcoming by pioneering the application of deep learning techniques to create synthetic control CT images (sCT) from combining IB-PET and planning CT scan data. Approach. We conducted simulations involving six patients who underwent irradiation with proton beams. Leveraging the architecture of a visual transformer (ViT) neural network, we developed a model to generate sCT images of these patients using the planning CT scans and the inter-fractional simulated PET activity maps during irradiation. To evaluate the model’s performance, a comparison was conducted between the sCT images produced by the ViT model and the authentic control CT images—serving as the benchmark. Main results. The structural similarity index was computed at a mean value across all patients of 0.91, while the mean absolute error measured 22 Hounsfield Units (HU). Root mean squared error and peak signal-to-noise ratio values were 56 HU and 30 dB, respectively. The Dice similarity coefficient exhibited a value of 0.98. These values are comparable to or exceed those found in the literature. More than 70% of the synthetic morphological changes were found to be geometrically compatible with the ones reported in the real control CT scan. Significance. Our study presents an innovative approach to surface the hidden anatomical information of IB-PET in proton therapy. Our ViT-based model successfully generates sCT images from inter-fractional PET data and planning CT scans. Our model’s performance stands on par with existing models relying on input from cone beam CT or magnetic resonance imaging, which contain more anatomical information than activity maps.
Exploring the impact of pH and temperature on TiC nanopowders syntesized via sol-gel and subsequent crystallization by carbothermal reduction method
Authors: Morshed Mohammad , Najafi Abolhassan , Khalaj Gholamreza 
Published: February 2024

Abstract
In the present study, titanium carbide powders with suitable morphology and nanometer particle size were synthesized by the sol–gel method to investigate the parameters affecting the properties of sol and the final powder. The initial sol was prepared in a four-component system of alkoxide-water-alcohol-citric acid based on the chemical process of sol–gel. The study of sol properties showed that pH was the most important factor in the control of sol conditions and particle size so that at low pHs, due to low concentration of OH− ions and reduced viscosity, it was easier to control the particles size. Accordingly, the results of the Dynamics Light Scattering (DLS) showed that at low pHs, the particles size was below 10 nm. According to the zeta potential diagram and by examining the conditions of sol at different pHs, 4.5 was determined as the optimal pH and to prevent the bonding of particles within the sol, ammonium polycarboxylate dispersant was used. The temperature at which particles were formed was determined using Differential thermal analysis (DTA) and Thermal gravimetric analysis (TG). X-ray diffraction (XRD) patterns showed the presence of a completely amorphous phase at 700 °C. It was also observed that with increasing temperature, TiC crystallization started from 1200 °C and ended at 1400 °C. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) micrographs at 1400 °C showed the completely spherical morphology of particles of nanometer size so that no agglomerate was observed.
Gravitational form factors of the proton from near-threshold vector meson photoproduction*
Authors: Wang 王 Xiao-Yun 晓云 , Zeng 曾 Fancong 凡聪 , Zhang 张 Jiyuan 纪元 
Published: February 2024

Abstract
We systematically analyze the quark and gluon gravitational form factors (GFFs) of the proton by connecting the energy-momentum tensor and near-threshold vector meson photoproduction (NTVMP). Specifically, the quark contributions of GFFs are determined by applying global fitting to the cross section of the lightest vector meson

photoproduction. Combined with the gluon GFFs obtained from heavy quarkonium

photoproduction data, the complete GFFs are obtained and compared with the experimental results and lattice quantum chromodynamics determinations. In addition, we use the resonance via Padé (RVP) method based on the Schlessinger point method to obtain a model-independent quark D-term distribution through direct analytical continuation of deeply virtual Compton scattering experimental data. If errors are considered, the results obtained with RVP are essentially consistent with those obtained by NTVMP. Moreover, the comprehensive information on GFFs helps to uncover the mass distribution and mechanical properties inside the proton. This study is not only an important basis for delving into the enigmatic properties of the proton, but also has significance for theoretically guiding future JLab and EIC experimental measurements.
Real-time control of NBI fast ions, current-drive and heating properties
Authors: Weiland M. , Kudlacek O. , Sieglin B. , Bilato R. , Plank U. , Treutterer W. , Upgrade Team the ASDEX ,   EUROfusion Tokamak Exploitation Team
Published: February 2024

Abstract
Conventionally, neutral beam injection (NBI) in tokamaks is controlled via engineering parameters such as injection voltage and power. Recently, the high-fidelity real-time NBI code RABBIT has been coupled to the discharge control system of ASDEX Upgrade. It allows to calculate the NBI fast-ion distribution and hence the properties of NBI in real-time, making it possible to control them directly. We successfully demonstrate control of driven current, ion heating and stored fast-ion energy by modifying the injected beam power. A combined ECRH and NBI controller is also successfully tested, which is able to adjust the heating mix between ECRH and NBI to match a certain desired ion heating fraction at given total power. Further experiments have been carried out towards control of the ion heat flux (i.e. ion heating plus collisional heat transfer between ions and electrons). They show good initial success, but also leave room for future improvements as the controller runs into instabilities at too high requests.
Bioassembly of hemoglobin-loaded photopolymerizable spheroids alleviates hypoxia-induced cell death
Authors: Norberg Axel E , Bakirci Ezgi , Lim Khoon S , Dalton Paul D , Woodfield Tim B F , Lindberg Gabriella C J 
Published: February 2024

Abstract
The delivery of oxygen within tissue engineered constructs is essential for cell survivability; however, achieving this within larger biofabricated constructs poses a significant challenge. Efforts to overcome this limitation often involve the delivery of synthetic oxygen generating compounds. The application of some of these compounds is problematic for the biofabrication of living tissues due to inherent issues such as cytotoxicity, hyperoxia and limited structural stability due to oxygen inhibition of radical-based crosslinking processes. This study aims to develop an oxygen delivering system relying on natural-derived components which are cytocompatible, allow for photopolymerization and advanced biofabrication processes, and improve cell survivability under hypoxia (1% O2). We explore the binding of human hemoglobin (Hb) as a natural oxygen deposit within photopolymerizable allylated gelatin (GelAGE) hydrogels through the spontaneous complex formation of Hb with negatively charged biomolecules (heparin, hyaluronic acid, and bovine serum albumin). We systematically study the effect of biomolecule inclusion on cytotoxicity, hydrogel network properties, Hb incorporation efficiency, oxygen carrying capacity, cell viability, and compatibility with 3D-bioassembly processes within melt electrowritten (MEW) scaffolds. All biomolecules were successfully incorporated within GelAGE hydrogels, displaying controllable mechanical properties and cytocompatibility. Results demonstrated efficient and tailorable Hb incorporation within GelAGE-Heparin hydrogels. The developed system was compatible with microfluidics and photopolymerization processes, allowing for the production of GelAGE-Heparin-Hb spheres. Hb-loaded spheres were assembled into MEW polycaprolactone scaffolds, significantly increasing the local oxygen levels. Ultimately, cells within Hb-loaded constructs demonstrated good cell survivability under hypoxia. Taken together, we successfully developed a hydrogel system that retains Hb as a natural oxygen deposit post-photopolymerization, protecting Hb from free-radical oxidation while remaining compatible with biofabrication of large constructs. The developed GelAGE-Heparin-Hb system allows for physoxic oxygen delivery and thus possesses a vast potential for use across broad tissue engineering and biofabrication strategies to help eliminate cell death due to hypoxia.
Intravenous push antibiotics in the emergency department: Education and implementation
Authors: Brady Rachel E , Giordullo Elizabeth L , Harvey Charles A , Krabacher Nicholas D , Penick Alyssa M 
Published: February 2024

Abstract

Purpose
Intravenous push antibiotics can serve as an alternative to intravenous piggyback antibiotics while providing the same pharmacodynamics and adverse effect profile, easing shortage pressures and decreasing order to administration time, as well as representing a potential cost savings. The purpose of this study was to determine whether intravenous push antibiotics could decrease the time from an order to the start of administration compared to piggyback antibiotics in emergency departments. This study also measured the cost savings of antibiotic preparation and administration and assessed nursing satisfaction when using intravenous push antibiotics.

Methods
Sample instances of use of intravenous push and piggyback antibiotics were identified. Patients were included if they were 18 years of age or older and received at least a single dose of intravenous push or piggyback ceftriaxone, cefepime, cefazolin, or meropenem in one of the institution’s emergency departments. The primary outcome of the study was to compare the time from the order to the start of administration of intravenous push vs piggyback antibiotics. The secondary outcome was to compare the cost of antibiotic preparation for the 2 methods.

Results
The intravenous push and piggyback groups each had 43 patients. The time from the order to the start of administration decreased from 74 (interquartile range, 29-114) minutes in the piggyback group to 31 (interquartile range, 21-52) minutes in the push group (P = 0.003). When the estimated monthly cost savings for ceftriaxone, cefepime, and meropenem were added together, across the emergency departments, an estimated $227,930.88 is saved per year when using intravenous push antibiotics.

Conclusion
Intravenous push antibiotics decrease the time from ordering to the start of administration and result in significant cost savings.
Recent and anticipated novel drug approvals for 2024
Authors: Rim Matthew H , Karas Brittany L , Barada Farah , Levitsky Andrew M 
Published: February 2024

Abstract

Purpose
Health-system pharmacists play a crucial role in monitoring the pharmaceutical pipeline to manage formularies, allocate resources, and optimize clinical programs for new therapies. This article aims to support pharmacists by providing periodic updates on new and anticipated novel drug approvals.

Summary
Selected drug approvals anticipated in the 12-month period covering the first quarter of 2024 through the fourth quarter of 2024 are reviewed. The analysis emphasizes drugs expected to have significant clinical and financial impact in hospitals and clinics, as selected from 59 novel drugs awaiting US Food and Drug Administration approval. This year’s pipeline includes recently added drugs with various indications including oncology, infectious diseases, genetic disorders, and rare diseases. New cellular and gene therapies are rapidly evolving and being studied for several rare diseases and cancers.

Conclusion
More oncology agents, including gene therapies, oral agents, and monoclonal antibodies, are in the pipeline this year. Additional diseases targeted by new novel drugs, including cellular and gene therapies, are hemophilia, nonalcoholic steatohepatitis, Alzheimer’s disease, and rare diseases such as galactosemia and epidermolysis bullosa.
Bariatric surgery patients in AUD treatment in Norway—an exploratory cross-sectional study
Authors: Bramness Jørgen G , Lien Lars , Moe Jenny S , Toft Helge , Pandey Susmita , Lid Torgeir G , Strømmen Magnus , Andersen John R , Bolstad Ingeborg 
Published: February 2024

Abstract

Aims
Patients who have undergone some forms of bariatric surgery have increased risk of developing alcohol use disorder (AUD). In the present observational study, we compared patients with AUD who themselves reported to having undergone bariatric surgery with other patients in treatment for AUD.

Materials
One-hundred-and-six consecutively enrolled patients in residential treatment for AUD were asked if they had undergone bariatric surgery. Sociodemographics, mental health-related, and alcohol use-related parameters were compared between those who had and those who had not undergone bariatric surgery.

Results
Of the 106 patients with AUD, seven (6.6%; 95% confidence interval, 2.7%–13.1%) had undergone bariatric surgery. Six of seven patients had undergone such surgery were women (P &lt; .001). The patients with AUD who had undergone bariatric surgery were similar to other patients with AUD on most other parameters, the exception being a larger number of alcohol units ingested to feel an effect of alcohol (adjusted odds ratio 7.1; 95% confidence interval 2.0–12.2; P = .007).

Conclusion
The high number of patients with AUD that reported having undergone bariatric surgery emphasizes the risks following such a procedure. The overrepresentation of women may reflect than more women undergo such procedures. The unexpected finding that patients with AUD having undergone bariatric surgery seemed to need more alcohol to feel intoxicated warrants further research.
Cutaneous immune-related adverse events: incidence rates, risk factors and association with extracutaneous toxicity – a prospective study of 189 patients treated with checkpoint inhibitors at a Spanish tertiary care hospital
Authors: Juan-Carpena Gloria , Martínez-Banaclocha Natividad , Palazón-Cabanes Juan Carlos , Niveiro-de Jaime María , Betlloch-Mas Isabel , Blanes-Martínez Mar 
Published: February 2024

Abstract

Background
Clinicians are increasingly prescribing immune checkpoint inhibitors (ICIs) to treat cancer, but the real-world incidence, characteristics and risk factors of cutaneous immune-related adverse events (cirAEs) are unclear.

Objectives
To determine the incidence, features and risk factors of cirAEs and to measure their possible association with extracutaneous toxicity.

Methods
We conducted a prospective observational study in a Spanish tertiary care hospital, including people who started an ICI between March 2020 and May 2022. We used a survival analysis and a log-rank test to obtain and compare incidence rates, and a multivariate Cox model to detect risk factors for cirAEs.

Results
We included 189 patients, 82 (43.4%) of whom presented cutaneous toxicity. The incidence of cirAEs was 75.0 per 100 person-years, with a 50.0% probability of the appearance of a cirAE at 10 months of follow-up. The most frequent cirAE category was inflammatory dermatoses, and the most frequent types were pruritus, eczema and maculopapular eruptions. ICI combination therapy, a family history of psoriasis and rheumatological and pulmonary immune-related adverse events increased the risk of cirAEs.

Conclusions
We found a high incidence of cirAEs, and they occurred early in the follow-up period. Dermatologists should be involved in the management of cirAEs, especially in people with risk factors.
Pericardial anisakiasis: unravelling diagnostic challenges in an unprecedented extra-abdominal manifestation: a case report
Authors: Giovacchini Jacopo , Menale Silvia , Scheggi Valentina , Marchionni Niccolò 
Published: February 2024

Abstract

Background
Anisakis infects humans by consuming contaminated undercooked or raw fish, leading to gastric anisakiasis, gastro-allergic anisakiasis, or asymptomatic contamination. Although larvae usually die when penetrating the gastric tissue, cases of intra- and extra-abdominal spread were described. We report the first probable case of pericardial anisakiasis.

Case summary
A 26-year-old man presented to the emergency department because of progressive lower limb oedema and exertional dyspnoea. Two months prior, he had consumed raw fish without any gastrointestinal symptoms. The echocardiogram reported a circumferential pericardial effusion (‘swinging heart’) and mildly reduced left ventricular ejection fraction (LVEF). He was diagnosed with myopericarditis after a cardiac magnetic resonance. A fluorodeoxyglucose positron emission tomography scan revealed an intense pericardial metabolism. Blood tests exhibited persistent eosinophilia and mild elevation of Anisakis simplex IgE—as for past infestation. A pericardial drainage was performed, subsequently, serial echocardiograms revealed a spontaneous recovery of his LVEF. No autoimmune, allergic, or onco-haematologic diseases were identified. Based on a history of feeding with potentially contaminated raw fish and on long-lasting eosinophilia, we suspected a pericardial anisakiasis, despite a low but persistent titre of specific IgE. Albendazole was administered for 21 days, along with colchicine and ibuprofen for 2 months; pericardial effusion resolution and eosinophil normalization occurred two weeks after.

Discussion
We hypothesized that Anisakis larvae may have migrated outside the gastrointestinal tract, penetrating the diaphragm and settling in the pericardium, causing pericarditis and pericardial effusion. Clinicians should know that the pericardium may be another extra-abdominal localization of anisakiasis, beyond pleuro-pulmonary involvement.
Unicuspid aortic valve by cardiac computed tomography: the best view is from the mountaintop—a case report
Authors: Rosencher Julien , Cescau Arthur , Baccouche Mohammed , Boyer Clément , Monin Jean Luc 
Published: February 2024

Abstract

Background
Unicuspid aortic valve (UAV) is a rare valvular heart disease and a challenging diagnosis. Advanced imaging techniques, particularly cardiac computed tomography (CT), appear to be invaluable tools to correctly identify this disease pre-operatively, as this may have an impact on the optimal surgical treatment.

Case summary
We describe the case of a young patient admitted with heart failure, due to a severely stenotic UAV. Cardiac CT allowed adjusting the imaging plane to the best view in two orthogonal planes to identify the top of the ‘dome’ and to accurately measure the smallest valve opening by planimetry. Surgical inspection confirmed a rare case of acommissural UAV.

Discussion
Cardiac CT angiography is crucial to understand the complexity of UAV disease and to differentiate the acommissural from the unicommissural type. Accurate positioning of the imaging plane through the smallest valve opening in systole reduces the risk of missing the diagnosis of this rare disease.
China, international competition and the stalemate in sovereign debt restructuring: beyond geopolitics
Authors: Hameiri Shahar , Jones Lee 
Published: February 2024

Abstract
Until recently, developing countries were supposedly enjoying an unprecedented ‘age of choice’ when borrowing. Many observers were arguing then that geopolitical competition between lenders allowed them to extract better terms. Today, many face a looming debt crisis: financing options have shrivelled and restructuring talks are painfully slow, compounding debtors' misery. This is frequently attributed to creditors' geopolitical rivalry, reflecting China's rise as a sovereign lender. But why should competition between providers, once supposedly a boon for borrowers, now be a bane? This article explains this, by switching an inadequate geopolitics lens for a political economy analysis. The earlier expansion in lending was primarily driven not by geopolitical contestation but by prevailing politico-economic conditions within China and on international financial markets amid US-led quantitative easing, and was, furthermore, facilitated by China's fragmented internal governance. As economic conditions changed, financing dried up and creditors scrambled to secure returns. China's current chief competitors are not western states, but rival lenders: commercial bondholders and multilateral development banks. Given China's fragmented governance, lenders' commercial motives to recoup their loans primarily drive Chinese behaviour, not geopolitical objectives. This limits China's hegemonic potential and suggests developing countries may benefit less from the ‘second Cold War’ than some imagine.