bluuebunny/crossref_metadata_2025_split huggingface dataset:
Russian development for drug independence in endocrinology: comparative analysis of bioequivalence, safety and tolerability of the first domestic liraglutide
Authors: Ametov A. S. , Shokhin I. E. , Rogozhina E. A. , Bodrova T. G. , Nevretdinova M. E. , Bely P. A. , Zaslavskaya K. Ya. , Kurkin D. V. , Koryanova K. N. , Mishchenko E. S. , Noskov S. M. 
Published: November 2023

Liraglutide is one of the analogues of the incretin hormone human glucagon-like peptide-1 (GLP-1) and is currently a priority treatment for diseases such as type 2 diabetes mellitus (mono- and combination therapy), obesity and overweight in the presence of at least one concomitant disease.The aim of the work was to assess the bioequivalence and comparability of the safety and tolerability profile of the drug Enligria® (liraglutide 6 mg/ml, Promomed RUS LLC, Russia) and the drug Saxenda® (liraglutide 6 mg/ml, Novo Nordisk AS, Denmark) after a single dose in healthy volunteers.Materials and methods. This study was an open-label, randomized, crossover comparative study to evaluate pharmacokinetic parameters, safety, tolerability and immunogenicity. The study comprised 26 healthy volunteers, 26 of whom were included in the bioequivalence assessment population. The study consisted of 2 periods, in each of which the volunteers received either the test drug (liraglutide at a single dose of 0.6 mg) or the reference drug (liraglutide at a single dose of 0.6 mg) once. The washout period between each dose was 7 days. Blood plasma samples were taken to determine the concentration of liraglutide in the range from 0 to 72 hours in each study period. Liraglutide concentrations were determined using a previously validated enzyme-linked immunosorbent assay (ELISA) method. A quantitative determination of antibodies to liraglutide in the blood serum samples was carried out using a microplate photometer and ready-made ELISA kits pre-validated by the manufacturer. The conclusion about the equivalence of the compared drugs was made based on the ratio of the parameters Cmax, AUC0→t and AUC0→t of the studied drug in relation to the reference one.Results. The pharmacokinetic parameters of the drugs were comparable to each other. The resulting 90% confidence intervals for the ratio of the values of Cmax, AUC0-t and AUC0-∞ of the Russian test and reference drug were 87.18–110.46, 84.40–104.11 and 86.69–103.22% respectively, which satisfied the criteria for assessing bioequivalence. The tolerability of the drugs in the volunteers was notified as good. The incidence of adverse events was comparable for the test and reference drugs. No serious adverse events were reported throughout the study. According to the results of the immunogenicity analysis, no antibodies to russian produced liraglutide were detected in the blood serum of the volunteers, which indicated the lack of the drug immunogenicity.Conclusion. During the study, the pharmacokinetic equivalence of the test and reference drugs was confirmed. The Russian drug Enligria® (liraglutide 6 mg/ml, Promomed RUS LLC, Russia) in comparison with a foreign drug Saxenda® (liraglutide 6 mg/ml, Novo Nordisk AS, Denmark).
Pendekatan Haptic Visuality pada Konstruksi Visual Film Burung Dara
Authors: Wasono Guntur Tri , Zamroni Muhammad , Aji Fajar 
Published: November 2023

Eros love is one of love that is identic with the sensation of arousal and sexual desire in the pattern of teenage romance. The content of love that is attached to the emotions of actors and sensation of desire makes the author take on the major cinematographer in film Burung Dara. Burung Dara tells the story of a couple teenage who having relationship beyond the bounds of the norm. The author uses a haptic visuality approach combined with emotional rhythm editing techniques to amplify emotions and give a touch-like sensation to the visuals of teenage love through a 27-minute film with a drama genre.
Peran Mise En Scene dalam Mendukung Penciptaan Humor pada Film Milly & Mamet (Ini Bukan Cinta & Rangga)
Authors: Abdillah Sintia , Hartanto Denny Antyo , Kartika Bambang Aris 
Published: November 2023

Film adalah bentuk karya seni berupa audio visual yang bertujuan untuk menghibur. Film bergenre komedi menjadi salah satu genre yang popular dikalangan masyarakat. Artikel ini membahas mise en scene dalam mendukung penciptaan humor pada film Milly & Mamet (Ini Bukan Cinta & Rangga). Film Milly & Mamet (Ini Bukan Cinta & Rangga) merupakan salah satu film bergenre komedi popular yang disutradarai oleh Ernest Prakasa. Film ini mengangkat cerita kehidupan Milly & Mamet yang penuh drama komedi dari segi cerita maupun karakternya. Film Milly & Mamet (Ini Bukan Cinta & Rangga) memliki selera humor yang berkualitas ditunjukkan melalui karakter pemain, dialog dan adegan-adegan yang menggelitik penonton. Penelitian ini merupakan jenis penelitian kualitatif dengan menggunakan metode deskriptif. Hasil penelitian yaitu humor tercipta mengggunakan teknik-teknik penciptaan humor yang kemudian disampaikan secara verbal maupun visual. Aspek-aspek mise sen scene seperti setting, wardrobe, make up, dan pemain serta pergerakannya mampu menampilkan humor melalui visual sehingga membuktikan bahwa mise en scene memiliki peran dalam menciptakan humor pada film Milly & Mamet (Ini Bukan Cinta & Rangga).
Ahmatnijar: URGENSI PEMBAHARUAN DALAM IJTIHAD FIQH: TELAAH HISTORIS DAN MODEL IJTIHAD KONTEMPORER A
Authors: Nijar Ahmat 
Published: November 2023

Abstract: The Prophet Muhammad SAW has already started the ijtihadpertice which is inspiring and do the regeneration to friend of the prophet. Ijtihad as an Islamic law developmend mover machine goes with full of dynamics and always needs touch of renewal.
Ijtihad fiqh renewal deals with a great struggle to rebuild arrange, recover the directions, mind set, or religious practice which involve real directing all obilities (bazl al-wus’i) to get practical syar’i through istinbath in facing contemporary dynamic challenge. This renewal must a futuristic ijtihad fiqh proces, not turn to a past process through qiraat al-mukarrah and it is expected can decorate the reportoine of old civilizations. Istinbath method which was applied was by combining nash text, sarwah fiqhiyah, , and ICT sistematically to bear an actual, futuristic, inspiring, and humanist fiqh fardli or fiqh taqdiry
Hip Morphology on Post-Reduction MRI Predicts Residual Dysplasia 10 Years After Open or Closed Reduction
Authors: Schmaranzer Florian , Justo Pedro , Kallini Jennifer R. , Ferrer Mariana G. , Miller Patricia , Bixby Sarah D. , Novais Eduardo N. 
Published: November 2023

Background:
There is limited evidence supporting the value of morphological parameters on post-reduction magnetic resonance imaging (MRI) to predict long-term residual acetabular dysplasia (RAD) after closed or open reduction for the treatment of developmental dysplasia of the hip (DDH).

Methods:
We performed a retrospective study of 42 patients (47 hips) undergoing open or closed reduction with a minimum 10 years of follow-up; 39 (83%) of the hips were in female patients, and the median age at reduction was 6.3 months (interquartile range [IQR], 3.3 to 8.9 months). RAD was defined as additional surgery with an acetabular index >2 standard deviations above the age- and sex-specific population-based mean value or Severin classification grade of >2 at last follow-up. Acetabular version and depth-width ratio, coronal and axial femoroacetabular distance, cartilaginous and osseous acetabular indices, transverse ligament thickness, and the thickness of the medial and lateral (limbus) acetabular cartilage were measured on post-reduction MRI.

Results:
At the time of final follow-up, 24 (51%) of the hips had no RAD; 23 (49%) reached a failure end point at a median of 11.4 years (IQR, 7.6 to 15.4 years). Most post-reduction MRI measurements, with the exception of the cartilaginous acetabular index, revealed a significant distinction between the group with RAD and the group with no RAD when mean values were compared. The coronal femoroacetabular distance (area under the receiver operating characteristic curve [AUC], 0.95; 95% confidence interval [CI], 0.90 to 1.00), with a 5-mm cutoff, and limbus thickness (AUC, 0.91; 95% CI, 0.83 to 0.99), with a 4-mm cutoff, had the highest discriminatory ability. A 5-mm cutoff for the coronal femoroacetabular distance produced 96% sensitivity (95% CI, 78% to 100%), 83% specificity (95% CI, 63% to 95%), 85% positive predictive value (95% CI, 65% to 96%), and 95% negative predictive value (95% CI, 76% to 100%). A 4-mm cutoff for limbus thickness had 96% sensitivity (95% CI, 78% to 100%), 63% specificity (95% CI, 41% to 81%), 71% positive predictive value (95% CI, 52% to 86%), and 94% negative predictive value (95% CI, 70% to 100%).

Conclusions:
Coronal femoroacetabular distance, a quantitative metric assessing a reduction’s concentricity, and limbus thickness, a quantitative metric assessing the acetabulum’s cartilaginous component, help to predict hips that will have RAD in the long term after closed or open reduction.

Level of Evidence:
Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Sacred & Pseudepigrapha Writings Symposium ‎‎(SPWI)‎ Textual Culture in Jewish and Christian ‎Intellectual Circles ‎‎
Authors: Luis Cobreros Goretti 
Published: November 2023

Congreso internacional celebrado en la Facultad de Filosofía y Letras de la Universidad de Córdoba el ‎3 de diciembre de 2018
“Un trattato che nega il dubbio e lʼinfedeltà dai cristiani monoteisti” attrubuito a Buṭrus al-Sadamantī Introduzione, traduzione e nota comparativa
Authors: Tawadrous Beshoy R. 
Published: November 2023

Butrus era un monaco e sacerdote, ed era considerato un uomo santo. La sola data conosciuta della sua vita è il 1260, quando scrisse un’opera dedicata al suo ex confratello nel monastero, Yusab vescovo di Akhmim.Nell’ unico manoscritto conosciuto questo trattato è anonimo, quindi vi debbono essere alcune riserve circa la sua attribuzione a Butrus. Va anche notato che, mentre gli stessi argomenti sono nel Trattato della credenza, i termini usati sono diversi. Lʼintenzione del trattato è chiaramente apologetico: vi si tratta della Trinità e della divinità di Cristo, le due dottrine oggetto di maggiori indagini da parte dei Musulmani.
Who tempted the woman? Variations of the Edenic episode in Jewish Apocalyptic literature
Authors: García E. Macarena 
Published: November 2023

The Jewish Apocalyptic tradition shows various conceptions about the origin of evil, which are developed throughout the history of this school of thought. In the third century a. C., the Book of the Watchers states that the descending of a rebellious group of angels to the earth seeking beautiful women is the direct cause of the origin of evil. Contrary to this myth, the tradition of Adam and Eve emerges as the main alternative. The eating of the forbidden fruit of the tree of knowledge by the first couple explains the hard life of humans and their mortality. Nevertheless, around the first century A. D., this last tradition is developed in such a way that the serpent of the garden is linked to a satanic figure in some of the texts. This is the case of the references to the Edenic episode in the Book of Parables, 2 Enoch, the Greek Apocalypse of Baruch, the Apocalypse of Abraham, and the Greek and Latin versions of Life of Adam and Eve. Even if not all of them detail the description of the superhuman power hidden in the shape of the serpent, both 2 Enoch and the Latin version of Life of Adam and Eve refer to its initial state as one of the angels of the celestial court. An interpretation that influences the New Testament as well. The Watchers and Satan are all considered as heavenly beings that encourage humankind to superior learning and whose acts lead to the introduction and spread of evil in the world. Therefore, the main purpose of this paper is to analyse these late Apocalyptic references to the story of Adam and Eve in comparison to the myth of the Watchers in order to show the possible syncretism amongst these traditions.
Un testimonio manuscrito de la primera edición del Corpus islamológico de Theodor Bibliander
Authors: González Muñoz Fernando 
Published: November 2023

El manuscrito Basel, Universitätsbibliothek A XIII 25 consiste en una suerte de borrador para la impresión de varias secciones del Corpus islamológico de Johannes Oporinus y Theodor Bibliander: Machumetis Saracenorum principis eiusque successorum vitae ac doctrina ipseque Alcoran, que fue publicado a inicios de 1543 en Basilea y reimpreso en 1550. Este estudio pretende destacar el interés de este documento, pues, por una parte, permite deja ver algunos aspectos del proceso editorial: correcciones, supresiones, errores de imprenta etc; por otra, aporta algunos textos ajenos al corpus, como son una lista fragmentaria de títulos latinos para las suras del Corán y una versión manuscrita del tratado de Theodor Bibliander: Ad nominis Christiani socios consultatio.
Mitochondrial and cellular function in fibroblasts, induced neurons, and astrocytes derived from case study patients: insights into major depression as a mitochondria-associated disease
Authors: Wetzel Christian , Cardon Iseline , Grobecker Sonja , Kücükoktay Selin , Bader Stefanie , Jahner Tatjana , Nothdurfter Caroline , Koschitzki Kevin-Thomas , Berneburg Mark , Stöhr Heidi , Weber Bernhard , Höring Marcus , Liebisch Gerhard , Braun Frank , Rothammer-Hampl Tanja , Riemenschneider Markus , Rupprecht Rainer , Milenkovic Vladimir 
Published: November 2023

Abstract
Background: The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria’s involvement in many mechanisms identified in depression, and high prevalence of MDD in individuals with mitochondrial disorders. Mitochondrial functions and energy metabolism are increasingly considered to be involved in MDD’s pathogenesis. This study focused on cellular and mitochondrial (dys)function in two atypical cases: an antidepressant non-responding MDD patient ("Non-R") and another with an unexplained mitochondrial disorder ("Mito").
Methods: Skin biopsies from these patients and controls were used to generate various cell types, including astrocytes and neurons, and cellular and mitochondrial functions were analyzed.
Results: Similarities were observed between the Mito patient and a broader MDD cohort, including decreased respiration and mitochondrial function. Conversely, the Non-R patient exhibited increased respiratory rates, mitochondrial calcium, and resting membrane potential.
Conclusions: The Non-R patient’s data offered a new perspective on MDD, suggesting a detrimental imbalance in mitochondrial and cellular processes, rather than simply reduced functions. Meanwhile, the Mito patient’s data revealed the extensive effects of mitochondrial dysfunctions on cellular functions, potentially highlighting new MDD-associated impairments. Together, these case studies enhance our comprehension of MDD.
Overcoming the H+ concentration-conductivity trade-off with heavily Sc-doped soft perovskite oxides
Authors: Tsujikawa Kota , Hyodo Junji , Fujii Susumu , Takahashi Kazuki , Kasamatsu Shusuke , Yamazaki Yoshihiro 
Published: November 2023

Abstract

Advances in electrochemical devices have primarily been driven by the discovery and development of electrolyte materials. Yet, the ideal electrolyte that combines high ionic conductivity with robust chemical and electrochemical stability remains elusive owing to trade-offs between ionic carrier concentration and conductivity in doped oxides. Here, we demonstrate that heavy Sc doping in soft perovskite oxides overcomes these limitations by creating fast conduction pathways for trapped protons along the ScO6 octahedra network. Specifically, BaSn0.3Sc0.7O3H0.65 and BaTi0.2Sc0.8O3H0.51 achieve high proton concentration and diffusivity, resulting in a total proton conductivity exceeding 0.01 Scm−1 at 300°C. Barium stannate, doped with 70 at% Sc, exhibits enduring chemical stability under humid 0.98 atm CO2 atmosphere for over 360 h, while maintaining a theoretical open-circuit voltage of 1.194 V and a proton conductivity of 0.01 Scm−1 during more than 100 h of continuous fuel cell operation at 300°C. Targeting softer oxides with maximum Sc solubility presents a promising route for developing fast, stable proton-conducting solid electrolytes operable at 300°C or lower.
Predicting Prostate Adenocarcinoma Patients’ Survival and Immune Signature: A Novel Risk Model Based on Telomere-Related Genes
Authors: Zheng Jiefang , Chen Jiahui , Li Hongxiao , Li Yuanchao , Dong Weimin , Jiang Xianhan 
Published: November 2023

Abstract
Background
Telomere-related genes (TRGs) play an essential role in the carcinogenesis and progression of prostate adenocarcinoma(PRAD). However, the prognostic value of TRGs remains unclear in PRAD.
Methods
We conducted a study using The Cancer Genome Atlas-Prostate Adenocarcinoma (TCGA-PRAD) dataset as the training group and the Memorial Sloan-Kettering Cancer Center (MSKCC) and Gene Expression Omnibus (GEO) datasets as the validation group. We developed a risk model and a nomogram to predict survival rates in patients with PRAD. The expression of model genes and their possible regulatory mechanisms were then analyzed. Furthermore, we explored the relationship between the risk model and immune cell infiltration, chemotherapy drug sensitivity, and specific signaling pathways using the CIBERSORT algorithm, the Genomics of Drug Sensitivity in Cancer (GDSC) database, and motif enrichment.
Results
The developed risk model was based on seven key TRGs (HELLS, TOP3A, SRC, LARP7, BUB3, THRSP, and GTF2H4). Moreover, this model was an independent prognostic factor for patients with PRAD and was significantly associated with T and N stages. Among seven TRGs, TOP3A and BUB3 were not only significantly positively correlated with the clinical T and N phases of PRAD, but also expression was significantly increased in PRAD tissues compared to adjacent normal tissues. The model was a good predictor of 1-, 3-, and 5-year survival, and patients in the high-risk group had significantly shorter overall survival than those in the low-risk group. The integrated nomogram can be a good predictor of 3- and 5-year survival in patients with PRAD. Finally, compared to the low-risk group, the high-risk group had a higher response to chemotherapy and immunosuppression, which provided potential guidance to treatment options for patients in the high-risk group.
Conclusion
In summary, a new risk model based on TRGs was successfully developed in PRAD. This risk model is valuable for guiding the selection of immunotherapy and chemotherapy in the clinical treatment of patients with PRAD.
Lifestyle Habit Changes and Mental Health Perceptions Among Women After Cancer Treatment: An Exploratory Qualitative Study in Vietnam
Authors: Nguyen Thi Hoa Huyen , Nguyen Thi Oanh , Tran Ngoc Tran , Nguyen Chau Anh , Liamputtong Pranee , Bui Khanh Linh 
Published: November 2023

Abstract

Aims: This qualitative study explores the experiences of women after cancer treatment in terms of habit changes and mental health perception.
Method: The study involved 10 women who had undergone cancer treatment, recruited from three major hospitals in Hanoi, Vietnam. One-on-one semi-structured interviews were conducted to collect data. Thematic analysis was adopted for data analysis.
Results: The findings of the study shed light on the various factors influencing lifestyle habit changes and mental health perception among women after cancer treatment. These factors include reliance on non-scientific sources, word-of-mouth sharing of health practices, the role of religion and spiritual belief, and the importance of relationships and support networks.
Conclusion: The study highlights the need for accessible and scientifically verified information for women after cancer treatment to make informed decisions about their health. It emphasizes the importance of addressing traditional beliefs and promoting evidence-based practices. Moreover, the study underscores the importance of social support and relationships in coping with the challenges of post-cancer experiences.
Detection of maize seed purity based on light weight deep learning
Authors: Gu siqi , Meng wei , Zhang yijian , Sun guodong , Miao yongzheng 
Published: November 2023

Abstract
Seed purity detection is essential for crop growth and development. Real-time detection can identify and screen impurities or other varieties in time, thereby improving seed quality, increasing crop yields, and ensuring food security. However, traditional seed purity detection methods are often have certain limitations and may struggle to meet the requirements of real-time detection. In order to make the real-time seed purity detection used in seed factories, markets or other scenarios, we propose the deep model SeedNet, which is formed by adjusting the VGG16 network structure. Building upon this foundation, we embedd the Ghost module with the aim of reducing the model’s parameter count and computational complexity, resulting in SeedNet-Ghost. Pruning techniques further lighten the network by removing redundant parameters from the model’s convolutional layers, meeting the requirements for real-time detection. Finally, SeedNet-Ghost achieves optimal performance under the pruning rate of 5%, with classification accuracy 99.17%, memory usage 3.54MB, and inference time 4.27ms. In the consistency verification system designed by us, the model also shows good performance. The average speed of detecting the image purity of multiple seeds reaches 254ms. The research results indicate that the approach in this paper can offer high precision, fast speed, and low memory usage for real-time detection, safeguarding crop growth and development.
Multidimensional Displacement Analysis of Semeru Volcano, Indonesia Following 2021 Eruption from Multitrack InSAR Observation
Authors: Suhadha Argo Galih , Harintaka Harintaka 
Published: November 2023

Abstract
Mount Semeru, one of the world's most active volcanoes, experiencing frequent eruptions and at least one significant eruption annually. Traditional monitoring methods, constrained by the existing geodetic infrastructure, have been augmented by Interferometry Synthetic Aperture Radar (InSAR) technology. Previous InSAR applications in Indonesia have primarily relied on Line-of-Sight (LOS) displacement measurements, utilizing a single orbital geometry. This study breaks new applications by leveraging two orbital geometries of the Sentinel-1 satellite, advancing beyond conventional one-dimensional observations to generate comprehensive multidimensional displacement time series. This approach enables the precise capture of vertical, east-west, and north-south components of surface motion at Semeru volcano. Our findings underscore the critical role of multitrack InSAR data in providing a nuanced understanding of volcanic deformation. By encompassing all three displacement components, our methodology delivers a more detailed and accurate depiction of the volcano's dynamics. Although the 2.5D displacement model proves adequate in certain scenarios, the full three-dimensional analysis reveals its superiority in monitoring slow surface deformation. This study not only demonstrates the enhanced capabilities of InSAR in volcanic monitoring but also sets a precedent for its application in other high-risk volcanic and tectonic regions. Furthermore, our research emphasizes the value of integrating InSAR data with other monitoring techniques, like Global Navigation Satellite System (GNSS), for cross-validation and accuracy enhancement. The synergy of these technologies offers a powerful tool for geoscientists, potentially enhancing our understanding of surface motion and contributing to more effective risk management in geologically active areas.