bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Azulene‐Based Crystalline Porous Covalent Organic Framework for Efficient Photothermal Conversion
Authors: Tian Peng‐Ju , Han Xiang‐Hao , Qi Qiao‐Yan , Zhao Xin 
Published: December 2023

AbstractThe designed synthesis of a crystalline azulene‐based covalent organic framework (COF‐Azu‐TP) is presented and its photothermal property is investigated. Azulene, a distinctive 5–7 fused ring non‐benzenoid aromatic compound with a large intramolecular dipole moment and unique photophysical characteristics, is introduced as the key feature in COF‐Azu‐TP. The incorporation of azulene moiety imparts COF‐Azu‐TP with broad‐spectrum light absorption capability and interlayer dipole interactions, which makes COF‐Azu‐TP a highly efficient photothermal conversion material. Its polyurethane (PU) composite exhibits a solar‐to‐vapor conversion efficiency (97.2%) and displays a water evaporation rate (1.43 kg m−2 h−1) under one sun irradiation, even at a very low dosage of COF‐Azu‐TP (2.2 wt%). Furthermore, COF‐Azu‐TP is utilized as a filler in a polylactic acid (PLA)/polycaprolactone (PCL) composited shape memory material, enabling rapid shape recovery under laser stimulation. A comparison study with a naphthalene‐based COF isomer further emphasizes the crucial role of azulene in enhancing photothermal conversion efficiency. This study demonstrates the significance of incorporating specific building blocks into COFs for the development of functional porous materials with enhanced properties, paving the way for future applications in diverse fields.
Crystallography, Charge Transfer, and Two‐Photon Absorption Relations in Molecular Cocrystals for Two‐Photon Excited Fluorescence Imaging
Authors: Hao Liangmeng , Liu Fan , Wang Xu , Kang Lei , Wang Yucheng , Wang Lingsong , Lin Zheshuai , Zhu Weigang 
Published: December 2023

AbstractTwo‐photon excited fluorescence imaging requires high‐performance two‐photon absorption (TPA) active materials, which are commonly intramolecular charge transfer systems prepared by traditional chemical synthesis. However, this typically needs harsh conditions and new methods are becoming crucial. In this work, based on a collaborative intermolecular charge transfer (inter‐CT) strategy, three centimeter‐sized organic TPA cocrystals are successfully obtained. All three cocrystals exhibit a mixed stacking arrangement, which can effectively generate inter‐CT between the donor and acceptor. The ground and excited state characterizations compare their inter‐CT ability: 1,2‐BTC > 2D‐BTC > 1D‐BTC. Transient absorption spectroscopy detects TCNB•−, indicating that the TPA mechanism arises from molecular polarization caused by inter‐CT. Meanwhile, 1,2‐BTC exhibits the highest excited‐state absorption and the longest excited‐state lifetime, suggesting a stronger TPA response. First‐principles calculations also confirm the presence of inter‐CT interactions, and the significant parameter Δµ which can assess the TPA capability indicates that inter‐CT enhances the TPA response. Besides, cocrystals also demonstrate excellent water solubility and two‐photon excited fluorescence imaging capabilities. This research not only provides an effective method for synthesizing TPA crystal materials and elucidates the connection between inter‐CT ability and TPA property but also successfully applies them in the fields of multi‐photon fluorescence bioimaging.
Hierarchical Surface Pattern on Ni‐Free Ti‐Based Bulk Metallic Glass to Control Cell Interactions
Authors: Cai Fei‐Fan , Blanquer Andreu , Costa Miguel B. , Schweiger Lukas , Sarac Baran , Greer A. Lindsay , Schroers Jan , Teichert Christian , Nogués Carme , Spieckermann Florian , Eckert Jürgen 
Published: December 2023

AbstractNi‐free Ti‐based bulk metallic glasses (BMGs) are exciting materials for biomedical applications because of their outstanding biocompatibility and advantageous mechanical properties. The glassy nature of BMGs allows them to be shaped and patterned via thermoplastic forming (TPF). This work demonstrates the versatility of the TPF technique to create micro‐ and nano‐patterns and hierarchical structures on Ti40Zr10Cu34Pd14Sn2 BMG. Particularly, a hierarchical structure fabricated by a two‐step TPF process integrates 400 nm hexagonal close‐packed protrusions on 2.5 µm square protuberances while preserving the advantageous mechanical properties from the as‐cast material state. The correlations between thermal history, structure, and mechanical properties are explored. Regarding biocompatibility, Ti40Zr10Cu34Pd14Sn2 BMGs with four surface topographies (flat, micro‐patterned, nano‐patterned, and hierarchical‐structured surfaces) are investigated using Saos‐2 cell lines. Alamar Blue assay and live/dead analysis show that all tested surfaces have good cell proliferation and viability. Patterned surfaces are observed to promote the formation of longer filopodia on the edge of the cytoskeleton, leading to star‐shaped and dendritic cell morphologies compared with the flat surface. In addition to potential implant applications, TPF‐patterned Ti‐BMGs enable a high level of order and design flexibility on the surface topography, expanding the available toolbox for studying cell behavior on rigid and ordered surfaces.
Genetic underpinning of historical afforestation with allochthonous Pinus cembra in the northwestern Swiss Alps
Authors: Sonnenwyl Vincent , Dauphin Benjamin , Fragnière Yann , Clément Benoît , Grünig Sandra , Brodbeck Sabine , Parisod Christian , Kozlowski Gregor , Gugerli Felix 
Published: December 2023

AbstractThroughout the last centuries, the structure and genetic composition of forests have been strongly affected by forest management. Over 30% of European forests are artificially regenerated, very often using translocated forest reproductive material, among these species the Swiss stone pine (Pinus cembra L.). In the late nineteenth and early twentieth centuries, the species was largely used for artificial afforestation in the northern Alps. However, only a few planted trees have survived. Therefore, we aimed to evaluate if the historical afforestation of P. cembra in the northwestern Swiss Alps relied on allochthonous material. We sampled 12 sites, genotyping 11 nuclear microsatellites, to infer the spatial genetic structure of regional populations, to test for genetic differences between natural and planted stands, and to infer potential source regions of planted stands using reference samples covering the entire Alps. Population genetic structure analysis allowed us to distinguish planted from natural stands and to determine that forest reproductive material used for plantations was not of regional origin. We found similar levels of genetic diversity between natural and planted stands. Assignment tests revealed that reproductive material for planting was translocated to the study area from two source regions, i.e., near the border of Switzerland and Austria, and further to the East, between Austria and Italy. Our study shows how genetic tools may inform about historical transfer of forest reproductive material, which still may affect the population genetic make-up of regional occurrences, e.g., because of reduced natural regeneration.
Cuproptosis-Associated lncRNA Gene Signature Establishes New Prognostic Profile and Predicts Immunotherapy Response in Endometrial Carcinoma
Authors: Jiang Xi-Ya , Hu Jing-Jing , Wang Rui , Zhang Wei-Yu , Jin Qin-Qin , Yang Yin-Ting , Mei Jie , Hong Lin , Yao Hui , Tao Feng , Li Jie-Jie , Liu Yu , Zhang Li , Chen Shun-Xia , Chen Guo , Song Yang , Zhou Shu-Guang 
Published: December 2023

AbstractUterine corpus endometrial carcinoma (UCEC), a prevalent kind of cancerous tumor in female reproductive system that has a dismal prognosis in women worldwide. Given the very limited studies of cuproptosis-related lncRNAs (CRLs) in UCEC. Our purpose was to construct a prognostic profile based on CRLs and explore its assess prognostic value in UCEC victims and its correlation with the immunological microenvironment.Methods: 554 UCEC tumor samples and 23 normal samples’ RNA-seq statistics and clinical details were compiled from data in the TCGA database. CRLs were obtained using Pearson correlation analysis. Using LASSO Cox regression, multivariate Cox regression, and univariate Cox regression analysis, six CRLs are confirmed to develop a risk prediction model at last.We identified two main molecular subtypes and observed that multilayer CRLs modifications were related to patient clinicopathological features, prognosis, and tumor microenvironment (TME) cell infiltration characteristics, and then we verified the prognostic hallmark of UCEC and examined its immunological landscape.Finally, using qRT-PCR, model hub genes’ expression patterns were confirmed. Results: A unique CRL signature was established by the combination of six differently expressed CRLs that were highly linked with the prognosis of UCEC patients. According to their CRLs signatures, the patients were divided into two groups: the low-risk and the high-risk groups. Compared to individuals at high risk, patients at low risk had higher survival rates (p < 0.001). Additionally, Cox regression reveals that the profiles of lncRNAs linked to cuproptosis may independently predict prognosis in UCEC patients. The 1-, 3-, and 5-year risks’ respective receiver operating characteristics (ROC) exhibited AUC values of 0.778, 0.810, and 0.854. Likewise, the signature could predict survival in different groups based on factors like stage, age, and grade, among others. Further investigation revealed differences between the different risk score groups in terms of drug sensitivity,immune cell infiltration,tumor mutation burden (TMB) score and microsatellite instability (MSI) score. Compared to the group of high risk, the low-risk group had greater rates of TMB and MSI. Results from qRT-PCR revealed that in UCEC vs normal tissues, AC026202.2, NRAV, AC079466.2, and AC090617.5 were upregulated,while LINC01545 and AL450384.1 were downregulated. Conclusions: Our research clarified the relationship between CRLs signature and the immunological profile and prognosis of UCEC.This signature will establish the framework for future investigations into the endometrial cancer CRLs mechanism as well as the exploitation of new diagnostic tools and new therapeutic.
Revealing the nuclearity of iron citrate complexes at biologically relevant conditions
Authors: Gracheva Maria , Klencsár Zoltán , Homonnay Zoltán , Solti Ádám , Péter László , Machala Libor , Novak Petr , Kovács Krisztina 
Published: December 2023

AbstractCitric acid plays an ubiquitous role in the complexation of essential metals like iron and thus it has a key function making them biologically available. For this, iron(III) citrate complexes are considered among the most significant coordinated forms of ferric iron that take place in biochemical processes of all living organisms. Although these systems hold great biological relevance, their coordination chemistry has not been fully elucidated yet. The current study aimed to investigate the speciation of iron(III) citrate using Mössbauer and electron paramagnetic resonance spectroscopies. Our aim was to gain insights into the structure and nuclearity of the complexes depending on the pH and iron to citrate ratio. By applying the frozen solution technique, the results obtained directly reflect the iron speciation present in the aqueous solution. At 1:1 iron:citrate molar ratio, polynuclear species prevailed forming most probably a trinuclear structure. In the case of citrate excess, the coexistence of several monoiron species with different coordination environments was confirmed. The stability of the polynuclear complexes was checked in the presence of organic solvents.
The Practical Bearings of Truth as Correspondence
Authors: Kaspers Tom 
Published: December 2023

AbstractPragmatists are usually very antagonistic toward the correspondence theory of truth. They contend that the evidence-transcendent standard entailed by the theory is antithetical to the pragmatist methodology of elucidating concepts by exposing their practical bearings. What use could truth be to us if it offers a target we cannot even see? After judging the correspondence theory to be in violation of the Pragmatic Maxim, the pragmatist is prone to banishing it to the wastelands of empty metaphysics, where nothing of practical importance could ever grow. This article makes the case that this unjust condemnation must be appealed and overturned. The ground for my case is an argument to the effect that the correspondence conception of truth can be practically advantageous, which provides proof of the fact that, contrary to popular pragmatist belief, the correspondence theory does comply with the Pragmatic Maxim.
Creative collaboration with interactive evolutionary algorithms: a reflective exploratory design study
Authors: Uusitalo Severi , Kantosalo Anna , Salovaara Antti , Takala Tapio , Guckelsberger Christian 
Published: December 2023

AbstractProgress in AI has brought new approaches for designing products via co-creative human–computer interaction. In architecture, interior design, and industrial design, computational methods such as evolutionary algorithms support the designer’s creative process by revealing populations of computer-generated design solutions in a parametric design space. Because the benefits and shortcomings of such algorithms’ use in design processes are not yet fully understood, the authors studied the intricate interactions of an industrial designer employing an interactive evolutionary algorithm for a non-trivial creative product design task. In an in-depth report on thein-situlongitudinal experiences arising between the algorithm, human designer, and environment, from ideation to fabrication, they reflect on the algorithm’s role in inspiring design, its relationship to fixation, and the stages of the creative process in which it yielded perceived value. The paper concludes with proposals for future research into co-creative AI in design exploration and creative practice.
Academic freedom growth and decline episodes
Authors: Lott Lars 
Published: December 2023

AbstractAcademic freedom is under threat across the globe and a wave of substantial academic freedom declines affects not only autocracies but also (liberal) democracies. However, although the development of academic freedom has generated scholarly attention, this article presents the first systematic conceptualization and measurement of academic freedom growth and decline episodes. In particular, this article systematically analyzes the development of academic freedom across the globe and shows that global development follows waves of growth and decline. The first growth wave started in the mid-1940s and was succeeded by a second growth wave that started around 1977 and lasted for more than 30 years resulting in the greatest improvement in academic freedom that has been recorded since 1900. However, since 2013, we see an ongoing decline wave in academic freedom. Overall, this article highlights how academic freedom developed over time and across the globe in waves of growth and decline.
A Tale of Enduring Myths: Buffon’s Theory of Animal Degeneration and the Regeneration of Domesticated Animals in Mid-19th Century Brazil
Authors: Penteado David Francisco de Moura 
Published: December 2023

AbstractThe long 19th century was a period of many developments and technical innovations in agriculture and animal biology, during which actors sought to incorporate new practices in light of new information. By the middle of the century, however, while heredity steadily became the dominant concept in animal husbandry, some policies related to livestock improvement in Brazil seemed to have been tailored following a climate-deterministic concept established in the mid-18th century by the French naturalist Georges-Louis Leclerc, the Comte de Buffon. His theory of animal degeneration posited, among other things, the necessity of recurrent crossbreeding to preserve animal species living in nonnative environments from climate-induced degeneration. Although largely discredited by the early 19th century, the teachings of the French naturalist seem to have found supporters in a Brazilian program to modernize national agriculture through the application of the natural sciences. Herein I examine the revival of Buffon’s theories in that government-sponsored program to improve animal husbandry and breeding techniques, including actual applications of this theory in the real world. Ultimately, I argue that Buffon’s theory of degeneration was used to tailor public policies and funding for the improvement of domesticated animals in Brazil between 1856 and 1860.
Two decades of SVT ablation in Denmark: a trend towards higher age, more comorbidity, and less prior use of antiarrhythmic and rate-limiting pharmacotherapy—a nationwide registry-based Danish study
Authors: Middelfart Charlotte , Tønnesen Jacob , Zörner Christopher R. , Da Riis-Vestergaard Lise , Pham Maria Hang Xuan , Pallisgaard Jannik Langtved , Ruwald Martin H. , Rasmussen Peter Vibe , Johannessen Arne , Hansen Jim , Worck Rene , Gislason Gunnar , Hansen Morten Lock 
Published: December 2023

Abstract
Background and aims
Trends in patient selection and use of pharmacotherapy prior to catheter ablation (CA) for supraventricular tachycardia (SVT) are not well described. This study examined temporal trends in patients undergoing first-time CA for regular SVT, including atrioventricular nodal re-entry tachycardia (AVNRT), accessory pathways (APs), and ectopic atrial tachycardia (EAT) on a nationwide scale in Denmark in the period 2001–2018.

Methods and results
Using Danish Nationwide registers, 9959 patients treated with first-time CA for SVT between 2001 and 2018 were identified, of which 6023 (61%) received CA for AVNRT, 2829 (28%) for AP, and 1107 (11%) for EAT. Median age was 55, 42, and 55 in the AVNRT, APs, and EAT group, respectively. The number of patients receiving CA increased from 1195 between 2001 and 2003 to 1914 between 2016 and 2018. The percentage of patients with a CHA2DS2-VASc score ≥ 2 increased in all patient groups. The number of patients who underwent CA with no prior use of antiarrhythmic- or rate limiting medicine increased significantly, though prior use of beta-blockers increased for AVNRT patients. Use of verapamil decreased in all three SVT groups (P < 0.05). Use of amiodarone and class 1C antiarrhythmics remained low, with the highest usage among EAT patients.

Conclusion
Between 2001 and 2018, CA was increasingly performed in patients with SVT, primarily AVNRT- and EAT patients. The burden of comorbidities increased. Patients undergoing CA without prior antiarrhythmic- or rate-limiting drug therapy increased significantly. Use of beta-blockers increased and remained the most widely used drug.

Graphical Abstract
Neural-network-based automatic trajectory adaptation for quality characteristics control in powder compaction
Authors: MoradiMaryamnegari Hoomaan , Hasseni Seif-El-Islam , Ganthaler Elias , Villgrattner Thomas , Peer Angelika 
Published: December 2023

Abstract
Future manufacturing systems will have to become more intelligent to be able to guarantee a constantly high quality of products while simultaneously reducing labor-intensive quality-assurance tasks to address the shortage in workforce. In this work, we study the application of neural networks to the field of powder metallurgy and more specifically the production of green parts as part of a typical sintering process. More specifically, we explore the usage of neural-network-based predictions in closed-loop control. We train neural networks based on a series of produced workpieces, and use these networks in closed-loop production to predict quality characteristics like weight and dimensions of the workpiece in real-time. Based on these predictions an adaptive trajectory planner adjusts then trajectory key points and with this the final piston trajectories to bring and keep quality characteristics of workpieces within tolerance. We finally compare the control performance of this neural network-based approach with a pure sensor-based approach. Results indicate that both approaches are able to bring and keep quality characteristics within their tolerance limits, but that the neural network-based approach outperforms the sensor-based approach in the transient phase, whereas in steady state the neural network needed to be updated from time to time to reach the same high performance as the sensor-based approach. Since updating needs to be performed only from time to time, required expensive sensors can be shared among multiple machines and thus, costs can be reduced. At the same time the superior prediction performance of the neural-network-based approach in transient phases can be exploited to accelerate setting up times for new workpieces. Future work will target the automation of the recording of the training dataset, the exploration of further machine learning methods as well as the integration of additional sensor data to further improve predictions.
Nudging Online Gamblers to Withdraw Money: The Impact of Personalized Messages on Money Withdrawal Among a Sample of Real-World Online Casino Players
Authors: Auer Michael , Griffiths Mark D. 
Published: December 2023

AbstractA number of scholars have argued that online gambling can be more problematic than land-based gambling. Motivating gamblers to withdraw money from their online gambling account could lower losses because there would be less money available to lose. Therefore, the present study investigated whether personalized messages are an effective way of ‘nudging’ gamblers to withdraw money from their online gambling account. The authors were given access to a secondary dataset by Nederlandse Loterij (the national Dutch Lottery operator) comprising 4049 online gamblers. Two types of messages were used to ‘nudge’ gamblers to withdraw money from their gambling account (i.e., a ‘winning streak’ message and a ‘withdrawal’ message). The findings indicated that (i) 38% of gamblers reading the ‘winning streak’ messages withdrew money from their gambling account on the same day, and (ii) 18% of gamblers reading the ‘withdrawal’ messages withdrew money from their gambling account on the same day. Gamblers who read personalized messages also withdrew larger amounts of money from their gambling accounts compared to gamblers who did not read personalized messages. The findings suggest that the personalized messages can have an impact on both the likelihood to withdraw money as well as the amount of money which was withdrawn and could help reduce gambling-related harm.