bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Understanding and Characterizing the Arbitrage Bot Scam In the Wild
Authors: Li Kai , Guan Shixuan , Lee Darren 
Published: December 2023

This paper presents the first comprehensive analysis of an emerging cryptocurrency scam named "arbitrage bot" disseminated on online social networks. The scam revolves around Decentralized Exchanges (DEX) arbitrage and aims to lure victims into executing a so-called "bot contract" to steal funds from them. To entice victims and convince them of this scheme, we found that scammers have flocked to publish YouTube videos to demonstrate plausible profits and provide detailed instructions and links to the bot contract.
To collect the scam at a large scale, we developed a fully automated scam detection system namedCryptoScamHunter, which continuously collects YouTube videos and automatically detects scams. Meanwhile,CryptoScamHunter can download the source code of the bot contract from the provided links and extract the associated scam cryptocurrency address. Through deployingCryptoScamHunter from Jun. 2022 to Jun. 2023, we have detected 10,442 arbitrage bot scam videos published from thousands of YouTube accounts. Our analysis reveals that different strategies have been utilized in spreading the scam, including crafting popular accounts, registering spam accounts, and using obfuscation tricks to hide the real scam address in the bot contracts. Moreover, from the scam videos we have collected over 800 malicious bot contracts with source code and extracted 354 scam addresses. By further expanding the scam addresses with a similar contract matching technique, we have obtained a total of 1,697 scam addresses. Through tracing the transactions of all scam addresses on the Ethereum mainnet and Binance Smart Chain, we reveal that over 25,000 victims have fallen prey to this scam, resulting in a financial loss of up to 15 million USD.
Overall, our work sheds light on the dissemination tactics and censorship evasion strategies adopted in the arbitrage bot scam, as well as on the scale and impact of such a scam on online social networks and blockchain platforms, emphasizing the urgent need for effective detection and prevention mechanisms against such fraudulent activity.
MetaVRadar: Measuring Metaverse Virtual Reality Network Activity
Authors: Lyu Minzhao , Tripathi Rahul Dev , Sivaraman Vijay 
Published: December 2023

The "metaverse", wherein users can enter virtual worlds to work, study, play, shop, socialize, and entertain, is fast becoming a reality, attracting billions of dollars in investment from companies such as Meta, Microsoft, and Clipo Labs. Further, virtual reality (VR) headsets from entities like Oculus, HTC, and Microsoft are rapidly maturing to provide fully immersive experiences to metaverse users. However, little is known about the network dynamics of metaverse VR applications in terms of service domains, flow counts, traffic rates and volumes, content location and latency, etc., which are needed to make telecommunications network infrastructure "metaverse ready" to support superlative user experience in the coming future.
This paper is an empirical measurement study of metaverse VR network behavior aimed at helping telecommunications network operators better provision and manage the network to ensure good user experience. Using illustrative hour-long network traces of metaverse sessions on the Oculus VR headset, we first develop a categorization of user activity into distinct states ranging from login home to streetwalking and event attendance to asset trading, and undertake a detailed analysis of network traffic per state, identifying unique service domains, protocols, flow profiles, and volumetric patterns, thereby highlighting the vastly more complex nature of a metaverse session compared to streaming video or gaming. Armed with the network behavioral profiles, our second contribution develops a real-time methodMetaVRadar to detect metaverse session and classify the user activity state leveraging formalized flow signatures and volumetric attributes. Our third contribution practically implementsMetaVRadar, evaluates its accuracy in our lab environment, and demonstrates its usability in a large university network so operators can better monitor and plan resources to support requisite metaverse user experience.
GuaNary: Efficient Buffer Overflow Detection In Virtualized Clouds Using Intel EPT-based Sub-Page Write Protection Support
Authors: Bitchebe Stella , Kone Yves , Olivier Pierre , Boukhobza Jalil , Bromberg Yérom-David , Hagimont Daniel , Tchana Alain 
Published: December 2023

Write buffer overflow is a widespread and prevalent memory safety violation in C/C++, reported as the top vulnerability in 2022 and 2023. Secure memory allocators are generally used to protect systems against attacks that may exploit buffer overflows. Existing allocators mainly rely on two types of countermeasures to prevent or detect write overflows: canaries and guard pages, each with pros and cons in terms of detection latency and memory footprint.
For virtualized cloud applications, this paper follows the Out of Hypervisor (OoH) trend and introduces GuaNary, a safety guard against write overflows, allowing synchronous detection at a low memory footprint cost. OoH is a new virtualization research axis introduced in 2022 advocating the exposure of hardware features for virtualization to the guest OS so that its processes can take advantage of them. Based on the OoH principle, GuaNary leverages Intel Sub-Page write Permission (SPP), a recent hardware virtualization feature that allows to write-protect guest memory at the granularity of 128B (namely, sub-page) instead of 4KB. We implement a software stack, LeanGuard, which promotes the utilization of SPP from inside virtual machines by new secure allocators that use GuaNary. Our evaluation shows that for the same number of protected buffers, LeanGuard consumes 8.3× less memory than SlimGuard, a recent state-of-art secure allocator. Further, for the same memory consumption, LeanGuard allows protecting 25× more buffers than SlimGuard.
An Analysis of Dosing-Related Postmarketing Requirements for Novel Oncology Drugs Approved by the U.S. Food and Drug Administration, 2012–2022
Authors: Collins Grace , McKelvey Brittany , Andrews Hillary S. , Allen Jeff D. , Stewart Mark D. 
Published: December 2023

Abstract
The FDA's Oncology Center of Excellence's (OCE) launch of Project Optimus signals increased focus on dose optimization approaches in oncology drug development, particularly toward optimization in the premarket setting. Although sponsors continue to adapt premarket study designs and approaches to align with FDA's expectations for dose optimization, including consideration of the optimal dosage(s), there are still instances where questions remain at the time of approval about whether the approved doses or schedules are optimal. In these cases, FDA can exercise regulatory flexibility by issuing postmarketing requirements (PMR) and avoid delaying patient access to promising therapies. This landscape analysis demonstrates that over the past decade (2012–2022), FDA frequently used PMRs to answer additional questions about dosing for novel oncology approvals. We found more than half of drugs (78/132, 59.1%) had a dosing PMR and observed a recent increase in PMRs intended to evaluate whether a lower dose could be more optimal. These results suggest there are opportunities to adapt premarket dose optimization strategies and leverage innovative development tools to ensure timely identification of the optimal dose.
Maps, Ontological Worlds and a Hybrid Modernity: Reading the Chinese Gazetteer Tukao of Tibet 1886
Authors: Hu Su 
Published: December 2023

Abstract
This paper explores difference within geographical writings in the transition to modernity in nineteenth century China. In some maps, the experiential realities of travelers were valued and expressed. More significantly, landscape maps sometimes pointed to a reality of absence rather than of presence. This contrasted with the arising modern commitment to triangulation, which deleted the phenomenological in favour of an omniscient ‘view from nowhere’. It is conventional to treat this transition as an expression of progress in which non-Western scholars started to undo a scientific deficit regarding precision and measurement with the use of new tools, or for postcolonial scholars to propose heroic resistance from native map makers. Against these interpretations, the minutiae in the 1886 Chinese gazetteer Tukao of Tibet do not simply show a progressive or coerced transition, but rather the expression of an inconsistent difference. Tukao reflects different survey methods, producing fundamentally incompatible ontological worlds. The paper shows that the Tukao does not legislate between different practices, and argues that the alterity in Tukao offers lessons for postcolonial theory and practice, avoiding both hegemony of modern science and relativism.
Bacteriological Profile and Antibiotic Susceptibility Patterns of Sepsis-Causing Bacteria at the Neonatal Intensive Care Unit of a Tertiary Health Care Facility in Ghana
Authors: Opare-Asamoah Kwame , Vicar Ezekiel Kofi , Acquah Samuel Ekuban , Quaye Lawrence , Alhassan Abdul-Mumin , Majeed Saeed F , Sakyi Abigail Asantewaa , Blankson Endorah Fotwe , Mensah Kwasi Boadu 
Published: December 2023

Background: Neonatal sepsis is a clinical emergency that requires sound evaluation supported by accurate laboratory analysis and timely clinical intervention for its management. This study, therefore, was conducted to identify bacteria causing neonatal sepsis and their susceptibility to the commonly prescribed antibiotic at the Neonatal Intensive Care Unit of a tertiary health care facility in the Northern Region of Ghana. Methods: Neonatal biodata were collected from patient folders, after which identification, isolation, and susceptibility of isolated bacteria to prescribed anti-bacterial (Kirby-Bauer disk diffusion method) were carried out on single venipuncture blood samples aseptically drawn from 275 neonates clinically diagnosed with sepsis. Results: 275 neonates took part in the study, of which 218 (79.3%) presented with early-onset sepsis (EOS) and 57 (20.7%) with late-onset sepsis (LOS). The laboratory results confirmed a septicemia prevalence of 70.3% among neonates clinically diagnosed with sepsis. Preterm delivery ( P = .01), hypothermia ( P = .001), and delivery at the tertiary healthcare facility were significantly associated with EOS ( P < .000), while low birth weight ( P = .012), duration of hospital stay ( P = .001), and delivery at the tertiary healthcare facility ( P < .000) were found to be significantly associated with LOS. Gram-positive cocci constituted 54.9% (107), with Gram-negative constituting 45.1% (88) of all the bacteria isolates. Coagulase-negative staphylococcus (CoNS) 70.1% (75) and Klebsiella species 39.8% (35) were the dominant Gram-positive and Gram-negative isolates, respectively. 57.8% and 55.8% of CoNS isolates were susceptible to ampicillin and amoxicillin/clavulanic acid, respectively. 93.5% of CoNS and all the isolated Staphylococcus aureus and Klebsiella species were susceptible to amikacin. Conclusions: Coagulase-negative staphylococcus (CoNS) and Klebsiella species were the predominant Gram-positive and negative sepsis-causing agents at the NICU, respectively. Amikacin exhibited the highest sensitivity to Gram-positive and negative causative agents, making it a strong candidate for consideration in the facility’s empirical treatment of neonatal sepsis.
Peripatric speciation within Torreya fargesii (Taxaceae) in the Hengduan Mountains inferred from multi-loci phylogeography
Authors: Kou Yixuan , Fan Dengmei , Cheng Shanmei , Yang Yi , Wang Meixia , Wang Yujin , Zhang Zhiyong 
Published: December 2023

Abstract
Background
The Hengduan Mountains (HDM) are one of the major global biodiversity hotspots in the world. Several evolutionary scenarios, especially in-situ diversification, have been proposed to account for the high species richness of temperate plants. However, peripatric speciation, an important mode of allopatric speciation, has seldom been reported in this region.

Results
Here, two chloroplast DNA regions and 14 nuclear loci were sequenced for 112 individuals from 10 populations of Torreya fargesii var. fargesii and 63 individuals from 6 populations of T. fargesii var. yunnanensis. Population genetic analyses revealed that the two varieties are well differentiated genetically (FST, 0.5765) and have uneven genetic diversity (π, 0.00221 vs. 0.00073 on an average of nuclear loci). The gene genealogical relationship showed that T. fargesii var. yunnanensis is inferred as derived from T. fargesii var. fargesii, which was further supported by the coalescent simulations (DIYABC, fastsimcoal2 and IMa2). By the coalescent simulations, the divergence time (~ 2.50–3.65 Ma) and the weak gene flow between the two varieties were detected. The gene flow was asymmetrical and only occurred in later stages of divergence, which is caused by second contact due to the population expansion (~ 0.61 Ma) in T. fargesii var. fargesii. In addition, niche modeling indicated that the two varieties are differentiated geographically and ecologically and have unbalanced distribution range.

Conclusions
Overall, T. fargesii var. fargesii is always parapatric with respect to T. fargesii var. yunnanensis, and the latter derived from the former in peripatry of the HDM following a colonization from central China during the late Pliocene. Our findings demonstrate that peripatric speciation following dispersal events may be an important evolutionary scenario for the formation of biodiversity hotspot of the HDM.
Dissecting cellular states of infiltrating microenvironment cells in melanoma by integrating single-cell and bulk transcriptome analysis
Authors: Shi Aiai , Yan Min , Pang Bo , Pang Lin , Wang Yihan , Lan Yujia , Zhang Xinxin , Xu Jinyuan , Ping Yanyan , Hu Jing 
Published: December 2023

Abstract
Background
Cellular states of different immune cells can affect the activity of the whole immune microenvironment.

Methods
Here, leveraging reference profiles of microenvironment cell states that were constructed based on single-cell RNA-seq data of melanoma, we dissected the composition of microenvironment cell states across 463 skin cutaneous melanoma (SKCM) bulk samples through CIBERSORT-based deconvolution of gene expression profiles and revealed high heterogeneity of their distribution. Correspondence analysis on the estimated cellular fractions of melanoma bulk samples was performed to identify immune phenotypes. Based on the publicly available clinical survival and therapy data, we analyzed the relationship between immune phenotypes and clinical outcomes of melanoma.

Results
By analysis of the relationships among those cell states, we further identified three distinct tumor microenvironment immune phenotypes: “immune hot/active”, “immune cold-suppressive” and “immune cold-exhausted”. They were characterized by markedly different patterns of cell states: most notably the CD8 T Cytotoxic state, CD8 T Mixed state, B non-regulatory state and cancer-associated fibroblasts (CAFs), depicting distinct types of antitumor immune response (or immune activity). These phenotypes had prognostic significance for progression-free survival and implications in response to immune therapy in an independent cohort of anti-PD1 treated melanoma patients.

Conclusions
The proposed strategy of leveraging single-cell data to dissect the composition of microenvironment cell states in individual bulk tumors can also extend to other cancer types, and our results highlight the importance of microenvironment cell states for the understanding of tumor immunity.
“Real-world” analysis of battery longevity of implantable cardioverter-defibrillators: an in-depth analysis of a prospective defibrillator database
Authors: de Almeida Fernandes Diogo , António Natália , Sousa Pedro A. , Preto Leonor , Madeira Marta , Elvas Luís , Gonçalves Lino 
Published: December 2023

Abstract
Background
There is a lack of evidence regarding contemporary implantable cardioverter-defibrillator (ICD) battery longevity. Our aim was to assess battery longevity in ICDs in a real-world setting.

Methods
Retrospective cross-sectional single center study of a prospectively collected database of consecutive patients who underwent ICD implantation from January 2010 to December 2015. Clinical data and battery longevity of all manufacturers were collected.

Results
A total of 351 patients (84.6% males, mean age of 61 ± 12 years) were included in the study (292 VVI; 6 VDD; 53 DDD). All manufacturers (Abbott, Biotronik, Boston, Medtronic and Microport) were equally represented in the study (p = 0.110). Median battery longevity was 10.8 years (11 years for VVI and 8.5 for DDD). After a follow-up time of 5 years, 98% of VVI and DDD were still in service (vs. industry-projected longevity of 98%). During this time, 89 patients (25.4%) underwent device replacement − 69 patients (77.5%) due to battery depletion, 6 patients due to infection, 3 patients due to dysfunction and 13 patients due to upgrade to CRT-D. Patients with Medtronic or Biotronik ICDs had a greater probability of being replaced earlier due to battery depletion (Biotronik HR 6.87, 95% CI 2.54–18.58, p < 0.001; Medtronic HR 6.08, 95% CI 2.45–15.06 p < 0.001).

Conclusions
VVI and DDD ICD battery longevity matched industry-projected longevity after 5 years of follow-up. Medtronic and Biotronik ICDs appeared to have an earlier battery depletion. Further randomized studies are required to ensure optimal care.
Systematic review and meta-analysis of mass spectrometry proteomics applied to ocular fluids to assess potential biomarkers of age-related macular degeneration
Authors: Guo Hanmu , Li Jianqing , Lu Peirong 
Published: December 2023

Abstract
Background
Age-related macular degeneration (AMD) is a significant cause of severe vision loss. The main purpose of this study was to identify mass spectrometry proteomics-based potential biomarkers of AMD that contribute to understanding the mechanisms of disease and aiding in early diagnosis.

Methods
This study retrieved studies that aim to detect differences relate to proteomics in AMD patients and healthy control groups by mass spectrometry (MS) proteomics approaches. The search process was accord with PRISMA guidelines (PROSPERO database: CRD42023388093). Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes Pathway Analysis (KEGG) were performed on differentially expressed proteins (DEPs) in the included articles using the DAVID database. DEPs were included in a meta-analysis when their effect size could be computed in at least two research studies. The effect size of measured proteins was transformed to the log2-fold change. Protein‒protein interaction (PPI) analysis was conducted on proteins that were statistically significant in the meta-analysis using the String online database.

Results
Eleven studies fulfilled the inclusion criteria, and 161 DEPs were identified. The GO analysis showed that AMD is significantly related to proteolysis, extracellular exosome and protein binding. In KEGG, the most significant pathway was the complement and coagulation cascades. Meta-analysis results suggested that eight proteins were statistically significant, and according to PPI results, the most significant four proteins were serotransferrin (TF), apolipoprotein A1 (APOA1), complement C3 (C3) and lipocalin-1 (LCN1).

Conclusions
Four possible biomarkers, TF, APOA1, C3 and LCN1, were found to be significant in the pathogenesis of AMD and need to be further validated. Further studies should be performed to evaluate diagnostic and therapeutic value of these proteins.
Understanding for whom, under what conditions and how smoking cessation services for pregnant women in the United Kingdom work—a rapid realist review
Authors: Tatton Claire , Lloyd Jenny 
Published: December 2023

Abstract
Background
Maternal smoking in pregnancy is associated with several adverse maternal and infant health outcomes including increased risk of miscarriage, stillbirth, low birth weight, preterm birth, and asthma. Progress to reduce rates of smoking at time of delivery in England have been slow and over the last decade, less than half of pregnant women who accessed services went onto report having quit. This realist review was undertaken to improve the understanding of how smoking cessation services in pregnancy work and to understand the heterogeneity of outcomes observed.

Methods
The initial programme theory was developed using the National Centre for Smoking Cession and Training Standard Treatment Programme for Pregnant Women and the National Institute for Health and Care Excellence guidance on treating tobacco dependency. A search strategy and inclusion criteria were developed. Four databases were searched to identify published papers and four websites were hand searched to identify any unpublished literature that could contribute to theory building. Realist logic was applied to the analysis of papers to identify the contexts in which the intended behaviour change mechanism(s) were triggered, or not, and towards what outcomes to develop context mechanism outcome configurations.

Results
The review included 33 papers. The analysis produced 19 context mechanism outcome configurations structured under five closely interconnected domains (i) articulating harm, (ii) promoting support, (iii) managing cravings, (iv) maintaining commitment and (v) building self-efficacy. This review identifies two key processes involved in how services achieve their effects: how material resources are implemented and relationships. Of the two key processes identified, more existing literature was available evidencing how material resources are implemented. However, the review provides some evidence that non-judgemental and supportive relationships with healthcare workers where regular contact is provided can play an important role in interrupting the social cues and social practice of smoking, even where those around women continue to smoke.

Conclusions
This review clarifies the range of interconnected and bi-directional relationships between services and the personal and social factors in women’s lives. It underscores the importance of aligning efforts across the models five domains to strengthen services’ ability to achieve smoking cessation.