bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and socio-economic characteristics of a cohort of MDR/XDR TB patients in Bucharest, Romania
Authors: Ivanova O , Baiceanu D , Bakuli A , Vogel M , Popa C , Dumitrescu A , Hoelscher M , Lange C , Ibraim E , Rachow A 
Published: October 2023

Abstract

Background
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) patients are likely to suffer from TB-related morbidity, social and economic consequences during and beyond anti-TB treatment. The aim of this study is to describe clinical and socio-economic outcomes of TB patients in Bucharest, Romania.

Methods
We have established a prospective cohort of patients with MDR/XDR TB followed for more than 2 years from TB diagnosis. We have collected TB-related, laboratory and clinical data, including chest X-ray, lung function measured by spirometry, St. George's Respiratory Questionnaire (SGRQ), and socio-economic information.

Results
From 50 enrolled participants, 31 remained in the study till month 6. 71% were male with mean age 46.7 (SD 15.4). 41.9% had a previous TB infection and median BMI of 20.3 kg/m2. Baseline CXR showed that on average 47.3% of the lung was affected, with 32.7% at month 6. The majority (71%) of participants had lung impairment at baseline, which remained stable till month 6. The total SGRQ score improved between baseline and month 6 (30 vs 22.8), but remained significantly worse compared to healthy individuals. 52% of participants stated that TB affected their social or private life as well as their household financially at treatment start.

Conclusions
From the start of anti-TB treatment patients are suffering from lung impairment and experiencing socio-economic impact of TB. This cohort demonstrates a slow and slight longitudinal improvement of these outcomes and brings awareness to the need of employing social and rehabilitation programs to target TB impact.

Key messages
• MDR/XDR TB patients suffer from a significant morbidity and socio-economic burden in Romania.
• Targeted measures are needed to address this burden during and after TB treatment.
The Musée Napoléonien: objects, performance and encountering the ‘spectacular past’ in the long nineteenth century
Authors: O’Brien Laura 
Published: October 2023

Abstract:
In the early months of 1903, a new play opened at the Théâtre du Château-d’Eau in Paris, La Chute de l’Aigle, telling the story of the weeks following Napoléon’s defeat at Waterloo. Though the play itself was not particularly remarkable, it is notable for the presence of a ‘Musée Napoléonien’, containing a selection of original Napoleonic objects, in the theatre’s foyer. This article takes this unusual coming together of Napoleonic display in theatre and material culture as a starting point to examine the interplay between these forms of historical representation in France in the long nineteenth century. It argues that, like theatrical performance, exhibitions of Napoleonic things—especially personal items and belongings—constituted part of the broader turn towards a ‘spectacular past’, where historical narratives and biography were mediated via entertainment and spectacle. It demonstrates how contemporaries read the display of the personal items of a historical figure in dramatic, narrative terms, underlining the interaction between the visions of the historical past being constructed in performance and in the display of historical objects. In looking at these popular opportunities for experiential engagement with the past, it suggests that—whether in theatre, in exhibitions or, as in La Chute de l’Aigle, in both—such phenomena should be understood as important elements in how historical knowledge is acquired.
Assembly and annotation of the black spruce genome provide insights on spruce phylogeny and evolution of stress response
Authors: Lo Theodora , Coombe Lauren , Gagalova Kristina K , Marr Alex , Warren René L , Kirk Heather , Pandoh Pawan , Zhao Yongjun , Moore Richard A , Mungall Andrew J , Ritland Carol , Pavy Nathalie , Jones Steven J M , Bohlmann Joerg , Bousquet Jean , Birol Inanç , Thomson Ashley 
Published: October 2023

Abstract
Black spruce (Picea mariana [Mill.] B.S.P.) is a dominant conifer species in the North American boreal forest that plays important ecological and economic roles. Here, we present the first genome assembly of P. mariana with a reconstructed genome size of 18.3 Gbp and NG50 scaffold length of 36.0 kbp. A total of 66,332 protein-coding sequences were predicted in silico and annotated based on sequence homology. We analyzed the evolutionary relationships between P. mariana and 5 other spruces for which complete nuclear and organelle genome sequences were available. The phylogenetic tree estimated from mitochondrial genome sequences agrees with biogeography; specifically, P. mariana was strongly supported as a sister lineage to P. glauca and 3 other taxa found in western North America, followed by the European Picea abies. We obtained mixed topologies with weaker statistical support in phylogenetic trees estimated from nuclear and chloroplast genome sequences, indicative of ancient reticulate evolution affecting these 2 genomes. Clustering of protein-coding sequences from the 6 Picea taxa and 2 Pinus species resulted in 34,776 orthogroups, 560 of which appeared to be specific to P. mariana. Analysis of these specific orthogroups and dN/dS analysis of positive selection signatures for 497 single-copy orthogroups identified gene functions mostly related to plant development and stress response. The P. mariana genome assembly and annotation provides a valuable resource for forest genetics research and applications in this broadly distributed species, especially in relation to climate adaptation.
Minding the source: toward an integrative theory of human–machine communication
Authors: Lee Eun-Ju 
Published: October 2023

Abstract
According to the computers are social actors (CASA) paradigm, a dominant theoretical framework for research on human–computer interaction, people treat computers as if they were people. Recent studies on human–machine communication (HMC) and human–artificial intelligence (AI) interaction, however, appear to focus on when and how people respond to machines differently than to human agents. To reconcile this apparent contradiction, this study reviews critically the two overarching theoretical explanations proposed and tested in each respective tradition, the mindlessness account and the machine heuristic. After elaborating on several conceptual and operational issues with each explanatory mechanism, an alternative theoretical model of HMC is proposed that integrates both research traditions and generates predictions that potentially deviate from the dual-process models. Lastly, it is discussed how recent developments in AI technology invite modifications to the current understanding of HMC and beyond.
Inflammatory Bowel Disease in Adults and Elderly: The Use of Selected Non-IBD Medication Examined in a Nationwide Cohort Study
Authors: Lund Ken , Zegers Floor Dijkstra , Nielsen Jan , Brodersen Jacob Broder , Knudsen Torben , Kjeldsen Jens , Larsen Michael Due , Nørgård Bente Mertz 
Published: October 2023

Abstract

Background
Real-world data on medications used for conditions other than inflammatory bowel disease (IBD) are sparse. We examined how the onset of IBD affects the prescription pattern of selected non-IBD medication and the risk of becoming an incident user.

Methods
This nationwide cohort study utilized data from Danish health registers. We included incident patients with young adult–onset IBD (18-39 years of age), adult-onset IBD (40-59 years of age), and elderly-onset IBD (60+ years of age), from 1998 to 2018 and followed all for 3 years. We examined redeemed prescriptions before and after the onset of IBD and estimated the risk of becoming a user of non-IBD medications using logistic regression models.

Results
We identified 36165 patients, 16 771 (46%) with young adult onset, 10615 (29%) with adult onset, and 8779 (24%) with elderly onset. The onset of IBD increased the use of antidepressants, antipsychotics, sedatives/hypnotics, opioids, nonopioid analgesics, antidiabetics, and proton pump inhibitors, even in patients with no other underlying comorbid diseases. The adjusted odds ratio for using antidepressants 1 year after the onset of IBD in elderly was 1.50 (95% confidence interval [CI], 1.14-1.82), in opioids 1.69 (95% CI, 1.45-1.95), in nonopioid analgesics 2.10 (95% CI, 1.77-2.48), in cardiovascular medication 2.20 (95% CI, 1.86-2.61), and in proton pump inhibitors 1.51 (95% CI, 1.31-1.74) compared with adults.

Conclusions
In all 3 age groups, the proportions of patients with redeemed prescriptions for several groups of non-IBD medication were significantly increased after the IBD diagnosis compared with before. The risk of becoming an incident user for several groups of non-IBD medication was increased in elderly patients.
Giant intrathoracic cystic schwannoma resected by video-assisted thoracoscopic surgery
Authors: Pourmolkara Domenico , Napolitano Antonio Giulio , Coviello Eleonora , Puma Francesco 
Published: October 2023

Abstract
Schwannoma is a benign tumour originating from the Schwann cells. Patients can remain asymptomatic, as the onset of symptoms usually depends on the compressive effect on adjacent organs; dimensional and morphological variability increase the time for the diagnosis. We report the case of a successful surgical resection, performed by video-assisted thoracoscopic surgery, on a patient with radiological evidence of a massive cystic intrathoracic neoformation, histologically revealed to be a peculiar Schwannoma.
Shortcomings of a Showpiece
Authors: Epik Aziz , Steinl Leonie 
Published: October 2023

Abstract
The German Code of Crimes Against International Law can be considered a ‘well-crafted’ law. It has not only been put to test in practice in several high-profile cases before German Higher Regional Courts, but it also serves as a model for the implementation of international criminal law into domestic legislation. Nevertheless, 20 years after its entry into force and from a point of view of substantive law, it is possible to identify areas of the Code that are in need of legislative reform, such as sexual and reproductive crimes, crimes against the environment, the crime of aggression, war crimes against property and the applicable sentencing ranges. This article provides an overview of these areas and discusses possible ways forward.
Genus-Wide Transcriptional Landscapes Reveal Correlated Gene Networks Underlying Microevolutionary Divergence in Diatoms
Authors: Walworth Nathan G , Espinoza Josh L , Argyle Phoebe A , Hinners Jana , Levine Naomi M , Doblin Martina A , Dupont Chris L , Collins Sinéad 
Published: October 2023

Abstract
Marine microbes like diatoms make up the base of marine food webs and drive global nutrient cycles. Despite their key roles in ecology, biogeochemistry, and biotechnology, we have limited empirical data on how forces other than adaptation may drive diatom diversification, especially in the absence of environmental change. One key feature of diatom populations is frequent extreme reductions in population size, which can occur both in situ and ex situ as part of bloom-and-bust growth dynamics. This can drive divergence between closely related lineages, even in the absence of environmental differences. Here, we combine experimental evolution and transcriptome landscapes (t-scapes) to reveal repeated evolutionary divergence within several species of diatoms in a constant environment. We show that most of the transcriptional divergence can be captured on a reduced set of axes, and that repeatable evolution can occur along a single major axis of variation defined by core ortholog expression comprising common metabolic pathways. Previous work has associated specific transcriptional changes in gene networks with environmental factors. Here, we find that these same gene networks diverge in the absence of environmental change, suggesting these pathways may be central in generating phenotypic diversity as a result of both selective and random evolutionary forces. If this is the case, these genes and the functions they encode may represent universal axes of variation. Such axes that capture suites of interacting transcriptional changes during diversification improve our understanding of both global patterns in local adaptation and microdiversity, as well as evolutionary forces shaping algal cultivation.
Daydreaming
Authors: Reynolds Paige 
Published: October 2023

AbstractModernist technique, most obviously stream of consciousness, has frequently been employed to make visible and public the reveries of women. Irish women’s contemporary fiction uses such tactics to underscore the ways in which real life intrudes on and reshapes this imaginative practice. In Night (1972), which riffs off the narrative techniques depicting Molly Bloom’s ruminations in Ulysses, Edna O’Brien demonstrates the limits of feminism and the sexual revolution in revamping individual psychology as well as in reworking modernist form. At the cusp of the twenty-first century, Ireland grappled with cultural alterations arising from the newfound affluence of the Celtic Tiger, widespread revelations of childhood sexual abuse across the island, and the promise of peace in Northern Ireland. Anne Enright’s The Gathering (2007) and Deirdre Madden’s Molly Fox’s Birthday (2008) focus on female characters in the throes of these contemporary conditions, adapting stream of consciousness to portray how the twenty-first century’s flush of goods and capital influenced the reveries of Irish women.
The Participatory Turn in Museum Curation as a Model for Person-centred Clinical Care
Authors: Fulford K. W. M. , Bergqvist Anna 
Published: October 2023

Abstract
The participatory turn in museum curation offers a powerful model for person-centred clinical care. The first section gives an outline of contemporary person-centred care focusing on the contested values arising (particularly but not only in mental health) from shared clinical decision-making between clinician and patient. The section then outlines the growing range of philosophical resources available for tackling contested values of this kind. With notable exceptions, aesthetics has to date been largely absent from these resources. The next section describes the participatory turn in museums curating and illustrates it with a museum-based project involving refugee migrants, The Silent University. This is an example of what the curator Maria Lind (2019, 2020, 2021) has characterized as ‘curating in the extended field’. The final section combines the considerations of the first two sections by exploring some of the features of the participatory turn that make it a powerful model for person-centred care. First and foremost in this regard are partnership working and dialogue. Interpreted through the philosopher, Hilde Hein’s (2006), agentic account of the participatory turn, these features point to the need for a similarly agentic understanding of shared clinical decision-making. Further features of the participatory turn important for person-centred care, particularly in mental health, include its focus on strengths. Interpreted within Lind’s concept of ‘curation in the extended field’, recovery in mental health can be described as ‘recovery in the extended field’. We conclude with brief comments on the wider significance of aesthetics in contemporary science-based and person-centred clinical care.
Chronic warming and dry soils limit carbon uptake and growth despite a longer growing season in beech and oak
Authors: Didion-Gency Margaux , Vitasse Yann , Buchmann Nina , Gessler Arthur , Gisler Jonas , Schaub Marcus , Grossiord Charlotte 
Published: October 2023

Abstract
Progressively warmer and drier climatic conditions impact tree phenology and carbon cycling with large consequences for forest carbon balance. However, it remains unclear how individual impacts of warming and drier soils differ from their combined effects and how species interactions modulate tree responses. Using mesocosms, we assessed the multiyear impact of continuous air warming and lower soil moisture alone or in combination on phenology, leaf-level photosynthesis, nonstructural carbohydrate concentrations, and aboveground growth of young European beech (Fagus sylvatica L.) and Downy oak (Quercus pubescens Willd.) trees. We further tested how species interactions (in monocultures and in mixtures) modulated these effects. Warming prolonged the growing season of both species but reduced growth in oak. In contrast, lower moisture did not impact phenology but reduced carbon assimilation and growth in both species. Combined impacts of warming and drier soils did not differ from their single effects. Under warmer and drier conditions, performances of both species were enhanced in mixtures compared to monocultures. Our work revealed that higher temperature and lower soil moisture have contrasting impacts on phenology vs. leaf-level assimilation and growth, with the former being driven by temperature and the latter by moisture. Furthermore, we showed a compensation in the negative impacts of chronic heat and drought by tree species interactions.
Sleep-EEG in comorbid pain and insomnia: implications for the treatment of pain disorders
Authors: Reid Matthew J. , Quigg Mark , Finan Patrick H. 
Published: October 2023

Abstract

Introduction:
Patients with chronic pain experience a high prevalence of comorbid insomnia, which is associated with functional impairment. Recent advances in sleep electroencephalography (sleep-EEG) may clarify the mechanisms that link sleep and chronic pain. In this clinical update, we outline current advancements in sleep-EEG assessments for pain and provide research recommendations.

Results:
Promising preliminary work suggests that sleep-EEG spectral bands, particularly beta, gamma, alpha, and delta power, may create candidate neurophysiological signatures of pain, and macro-architectural parameters (e.g., total sleep time, arousals, and sleep continuity) may facilitate EEG-derived sleep phenotyping and may enable future stratification in the treatment of pain.

Conclusion:
Integration of measures obtained through sleep-EEG represent feasible and scalable approaches that could be adopted in the future. We provide research recommendations to progress the field towards a deeper understanding of their utility and potential future applications in clinical practice.
Risk of Recurrence after Surgical Resection for Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasia (IPMN) with Patterns of Distribution and Treatment
Authors: Lucocq James , Hawkyard Jake , Robertson Francis P. , Haugk Beate , Lye Jonathan , Parkinson Daniel , White Steve , Mownah Omar , Zen Yoh , Menon Krishna , Furukawa Takaaki , Inoue Yosuke , Hirose Yuki , Sasahira Naoki , Feretis Michael , Balakrishnan Anita , Zelga Piotr , Ceresa Carlo , Davidson Brian , Pande Rupaly , Dasari Bobby , Tanno Lulu , Karavias Dimitrios , Helliwell Jack , Young Alistair , Nunes Quentin , Urbonas Tomas , Silva Michael , Gordon-Weeks Alex , Barrie Jenifer , Gomez Dhanny , van Laarhoven Stijn , Doyle Joseph , Bhogal Ricky , Harrison Ewen , Roalso Marcus , Ciprani Debora , Aroori Somaiah , Ratnayake Bathiya , Koea Jonathan , Capurso Gabriele , Bellotti Ruben , Stättner Stefan , Alsaoudi Tareq , Bhardwaj Neil , Jeffery Fraser , Connor Saxon , Cameron Andrew , Jamieson Nigel , Sheen Amy , Mittal Anubhav , Samra Jas , Gill Anthony , Roberts Keith , Soreide Kjetil , Pandanaboyana Sanjay 
Published: October 2023

Objective:
This international multicentre cohort study aims to identify recurrence patterns and treatment of first and second recurrence in a large cohort of patients after pancreatic resection for adenocarcinoma arising from IPMN.

Summary Background Data:
Recurrence patterns and treatment of recurrence post resection of adenocarcinoma arising from IPMN are poorly explored.

Method:
Patients undergoing pancreatic resection for adenocarcinoma from IPMN between January 2010 to December 2020 at 18 pancreatic centres were identified. Survival analysis was performed by the Kaplan-Meier log rank test and multivariable logistic regression by Cox-Proportional Hazards modelling. Endpoints were recurrence (time-to, location, and pattern of recurrence) and survival (overall survival and adjusted for treatment provided).

Results:
Four hundred and fifty-nine patients were included (median, 70 y; IQR, 64-76; male, 54 percent) with a median follow-up of 26.3 months (IQR, 13.0-48.1 mo). Recurrence occurred in 209 patients (45.5 percent; median time to recurrence, 32.8 months, early recurrence [within 1 y], 23.2 percent). Eighty-three (18.1 percent) patients experienced a local regional recurrence and 164 (35.7 percent) patients experienced distant recurrence. Adjuvant chemotherapy was not associated with reduction in recurrence (HR 1.09;P=0.669) One hundred and twenty patients with recurrence received further treatment. The median survival with and without additional treatment was 27.0 and 14.6 months (P<0.001), with no significant difference between treatment modalities. There was no significant difference in survival between location of recurrence (P=0.401).

Conclusion:
Recurrence after pancreatic resection for adenocarcinoma arising from IPMN is frequent with a quarter of patients recurring within 12 months. Treatment of recurrence is associated with improved overall survival and should be considered.
Predicting high-intensity resuscitation needs in injured patients in the post-hemostasis phase of care following intervention
Authors: Weykamp Michael B. , Beni Catherine E. , Stern Katherine E. , O’Keefe Grant E. , Brakenridge Scott C. , Chan Kwun C.G. , Robinson Bryce R.H. 
Published: October 2023

BACKGROUND
Best resuscitation practices in the posthemostasis phase of care are poorly defined; this phase of care is characterized by a range of physiologic derangements and multiple therapeutic modalities used to address them. Using a cohort of injured patients who required an immediate intervention in the operating room or angiography suite following arrival to the emergency department, we sought to define high-intensity resuscitation (HIR) in this posthemostasis phase of care; we hypothesized that those who would require HIR could be identified, using only data available at intensive care unit (ICU) admission.

METHODS
Clinical data were extracted for consecutive injured patients (2016–2019) admitted to the ICU following an immediate procedure in the operating room or angiography suite. High-intensity resuscitation thresholds were defined as the top decile of blood product (≥3 units) and/or crystalloid (≥4 L) use in the initial 12 hours of ICU care and/or vasoactive medication use between ICU hours 2 and 12. The primary outcome, HIR, was a composite of any of these modalities. Predictive modeling of HIR was performed using logistic regression with predictor variables selected using Least Absolute Shrinkage and Selection Operator (LASSO) estimation. Model was trained using 70% of the cohort and tested on the remaining 30%; model predictive ability was evaluated using area under receiver operator curves.

RESULTS
Six hundred five patients were included. Patients were 79% male, young (median age, 39 years), severely injured (median Injury Severity Score, 26), and an approximately 3:2 ratio of blunt to penetrating mechanisms of injury. A total of 215 (36%) required HIR. Predictors selected by LASSO included: shock index, lactate, base deficit, hematocrit, and INR. The area under receiver operator curve for the LASSO-derived HIR prediction model was 0.82.

CONCLUSION
Intensive care unit admission data can identify subsequent HIR in the posthemostasis phase of care. Use of this model may facilitate triage, nursing ratio determination, and resource allocation.

LEVEL OF EVIDENCE
Therapeutic/Care Management; Level IV.