bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pandemic 19 On Children's Rights In Abroad Families (Study In Pringtutul Hamlet, Kalisabuk Village, Kesugihan District, Cilacap District)
Authors: Faroqi Moh. Ingam 
Published: December 2023

Corona virus or covid-19 is A spreading epidemic to several countries or continents and in general infected Lots human beings and impact on rights child in the family overseas, From the results his research that in Hamlet Pringtutul , it turns out Still There is right child who doesn't obtain her rights like right education , religious rights , rights social and rights health by parents consequence The Covid-19 pandemic , because factor economic , family , social or environmental , parents , schools , facilities , infrastructure and religion. As for effort family overseas to rights child For obtain religious rights , rights education , rights social and rights health that is First , parents role active to child related with matter formal and non - formal education as well as parents must help or direct child in study school so no wrong or wrong in learning . Third , nature love Darling or parental attention given to Â child more priority under the circumstances like this, especially in terms of religion, education , social and health so that more effective in reciting at the mosque / prayer room / TPQ, effective in learning at school , effective in interaction social , effective in guarding health so no There is difficulties and obstacles for kids at the moment Full Covid-19 pandemic limitations learning and religious activities at the mosque / musholla / TPQ always improved
”Kyllähän siitä omasta vastuusta puhutaan aika paljonkin aikuisten kanssa.” Asiakkaiden vastuullistaminen sosiaalityöntekijöiden haastattelupuheessa
Authors: Ojanen Karoliina 
Published: December 2023

Artikkelissa tarkastellaan nuoriin aikuisiin kohdistuvaa vastuullistamista aikuissosiaalityössä ja kysytään, minkälaisiin yhteiskunnallisiin taustaolettamiin ja ihanteisiin järkeily ja harkinta käytännön tasolla pohjaavat erityisesti vastuullistamisen näkökulmasta. Aineisto on muodostettu haastattelemalla kunnallisen aikuissosiaalityön työntekijöitä, ja aineiston analyysissa on hyödynnetty diskurssianalyysia. Haastattelukerronnassa tuotetaan käsitystä vastuullisista ja vastuullisuuteen opetettavista asiakkaista, mikä istuu rikkonaisesti arjen työhön ja aiheuttaa ristiriitoja. Haastateltavien kerronnassa voi nähdä vuorottelevan yksilön vastuun ja vastuullistamisen kiistämättömyys ja kontekstit huomioiva harkinta. Työtä ohjaavat yhteiskunnalliset taustaoletukset törmäävät sosiaalityön arjen todellisuuteen: ihmisten tilanteiden ja toimintakyvyn arviointi on jatkuvassa ristiriidassa vallitsevan yksilöllistymistä painottavan ideologian kanssa.
Retorno das atividades presenciais nos cursos de Odontologia brasileiros na pandemia de COVID-19
Authors: Fornazari Renata Cristina Soares , Freitas André Gabriel , Silva Junior Manoelito Ferreira , Carcereri Daniela Lemos , Warmling Cristine Maria , Fontanella Vania Regina Camargo , Moysés Samuel Jorge , Baldani Márcia Helena 
Published: December 2023

Trata-se de estudo quanti-qualitativo que analisa o retorno das atividades presenciais nos cursos de Odontologia brasileiros, durante a pandemia de COVID-19, e as dificuldades enfrentadas, comparando instituições públicas e privadas. Um formulário on-line com questões abertas e fechadas foi encaminhado por e-mail aos representantes dos cursos de Odontologia, de março a junho de 2021. Foram incluídos os cursos cadastrados no site e-MEC iniciados até 2017. A análise quantitativa utilizou os testes qui-quadrado, exato de Fisher e t de Student (p<0,05); uma questão aberta foi submetida à análise temática de conteúdo. Dos 329 cursos elegíveis, foram respondidos 83 formulários (21 públicos e 62 privados). Os cursos de instituições públicas apresentaram menor frequência de retorno das atividades presenciais até a data da coleta (p=0,038), inclusive com maior proporção de suspensão das atividades clínicas e laboratoriais (p≤0,001), mas sem diferença para aulas teóricas remotas (p>0,05). Os cursos privados demonstraram ter maior disponibilidade de recursos para o retorno presencial, tais como: estrutura, funcionários e docentes (p<0,001). Apesar das normas de biossegurança constituírem um desafio comum, as principais dificuldades relatadas nas instituições privadas diante do retorno das atividades presenciais foram a modulação ou escalonamento das turmas e ambientes de aula, controle do fluxo de pessoas e implantação de protocolos. Nas públicas, destacam-se dificuldades relacionadas à adequação da estrutura e aquisição de materiais. Conclui-se que a maioria dos cursos de Odontologia havia retomado às aulas no início de 2021, mas as instituições privadas apresentaram maior proporção de retorno às atividades laboratoriais e clínicas presenciais.
Surgical resection of recurrent differentiated thyroid cancer: patterns, detection, staging, and treatment of 683 patients
Authors: Liang Nan , Zhang Han , Sui Chengqiu , Du Rui , Li Canxiao , Li Jingting , Dionigi Gianlorenzo , Zhang Daqi , Sun Hui 
Published: December 2023

BackgroundDespite improvements in overall survival, the recurrence of differentiated thyroid cancer (DTC) is becoming more common and remains a challenge necessitating accurate reappraisal of the patient. This study aimed to describe the characteristics, reasons, morbidity, and strategies of second operations for DTC.MethodsThis was a retrospective observational study of patients with DTC who underwent a second surgery between June 2008 and June 2021 in the Department of Thyroid Surgery at China–Japanese Union Hospital, Jilin University, P.R. China. All clinical characteristics were recorded, and the analysis was estimated using SPSS.ResultsSecond surgeries were detected in 683 patients. The proportion of second operations changed with the update of international guidelines from 2015 (P &lt; 0.001). The true recurrence rate progressively increased from 21.3% to 61.5%. The rate of an “absence of preoperative FNA” or an “absence of intraoperative pathology at first surgery” decreased from 49.8% to 12.7%, while that of a “misdiagnosis of preoperative FNA at second surgery” decreased from 10% to 1.8%. The most common tumor location during the second surgery was the lateral lymph nodes (n = 104, 36.5%), with a median time to relapse of 36 months. Completion of thyroidectomy and lymph node dissection correlated with the second operation.ConclusionAfter 2015, second surgeries were more standardized, the incidence of complications decreased, and real recurrence became the most common reason for a second DTC surgery.
Mesenchymal stem cell-derived exosomes can alleviate GVHD and preserve the GVL effect in allogeneic stem cell transplantation animal models
Authors: Jiang Yan , Zhao Jie , Wang Minghui , Huang Fang , Li Jiaqi , Liu Rui , Wan Jiangbo , Hao Siguo 
Published: December 2023

BackgroundMesenchymal stem cells (MSCs) can alleviate graft-versus-host disease (GVHD) in hematopoietic stem cell transplantation (HSCT). MSCs-derived exosomes (MEXs) can mirror the biological function of their parent cells. Whether MEXs can alleviate GVHD like their parent cells or not is unclear. In this study, we investigate the effects of MEXs on GVHD and graft-versus-leukemia (GVL) effect in vitro and in HSCT animal models.MethodMSCs were produced using bone marrow mononuclear cells (MNCs), and MEXs were separated from the supernatants of MSCs. Electron microscopy, western blot, and nanoparticle tracking analysis (NTA) were used to determine the characteristics of MEXs. The immunomodulatory function of MEXs and their effects on GVHD and GVL were examined in vitro and in vivo.ResultLike other cell-type derived exosomes, our data revealed that MEXs were also disc-shaped vesicles with a diameter of 100–200 nm under electron microscopy and were positive for the exosomal hallmark proteins. MEXs can notably inhibit the expression of costimulatory molecules and functional cytokine secretion of dendritic cells (DCs). Meanwhile, MEXs can exert suppressive effects on T lymphocyte proliferation and activation. Moreover, MEXs can also encourage the polarization of macrophages toward the M2 type. In animal HSCT models, MEXs can promote the differentiation of Treg cells in spleens, decrease the GVHD score, increase the survival rate of mice, and preserve the cytotoxic antileukemia effects of CD8+ T lymphocytes from recipient mice.ConclusionThese findings showed that MEXs exert their effects by inhibiting the immunomodulatory function of DCs, macrophages, and T lymphocytes. In the animal model, MEXs ameliorate the clinical symptoms of GVHD, while maintaining the antitumor effects of CD8+ T lymphocytes. Therefore, it can be inferred that MEXs can separate GVHD from GVL in HSCT. Our study suggests that MEXs have broad clinical application potential in the prevention and treatment of GVHD in HSCT in the near future.
Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma
Authors: Bai Qingquan , Li Runyang , He Xiao , Hong Xiaoting , Yan Ying , Zhao Zhengyang , Lin Han , Tacke Frank , Engelmann Cornelius , Hu Tianhui 
Published: December 2023

IntroductionImmune cells play crucial roles in the development of chronic hepatitis B virus (HBV) infection, leading to cirrhosis and hepatocellular carcinoma (HCC). However, their functions at different disease stages are not fully understood.MethodsIn this study, we used single-cell RNA sequencing (scRNA-seq) to characterize the human liver immune microenvironment at different disease stages. We analyzed scRNA-seq data from 118,455 immune cells obtained from livers of six healthy individuals, four patients with HBV infection, five patients with HBV cirrhosis, and three patients with HBV-associated HCC.ResultsOur results showed an accumulation of scar-associated macrophages during disease progression, and we identified two relevant immune subsets, Macrophage-CD9/IL18 and macrophage-CD9/IFI6. Macrophage-CD9/IL18 expanded from HBV infection to cirrhosis, while macrophage-CD9/IFI6 expanded from cirrhosis to HCC. We verified the existence of Macrophage-CD9/IFI6 using multiplex immunofluorescence staining. We also found an increase in cytotoxic NK Cell-GNLY during progression from cirrhosis to HCC. Additionally, the proportion of CD4 T cell-TNFAIP3, CD8 T cell-TNF (effector CD8 T cells), and CD8 T cell-CD53 increased, while the proportion of Treg cells decreased from HBV infection to cirrhosis. The proportion of Treg and CD8 T cell-LAG3 (Exhausted CD8 T cell) enhanced, while the proportion of CD8 T cell-TNF (effector CD8 T cells) decreased from cirrhosis to HCC. Furthermore, GSEA enrichment analyses revealed that MAPK, ERBB, and P53 signaling pathways in myeloid cells were gradually inhibited from HBV infection to cirrhosis and HCC.DiscussionOur study provides important insights into changes in the hepatic immune environment during the progression of HBV-related liver disease, which may help improve the management of HBV-infected liver diseases.
Political news on Instagram: influencer versus traditional magazine and the role of their expertise in consumers’ credibility perceptions and news engagement
Authors: Zimmermann Daniel , Klee Asina , Kaspar Kai 
Published: December 2023

IntroductionSocial networking sites (SNS) are increasingly used by consumers to read and share political news. In this context, Instagram plays an important role due to its prevalence and visual characteristics. However, previous research has highlighted that consumers fail to identify the source of online news, though source characteristics were shown to be vital for news credibility perceptions. Nevertheless, research on whether and which source characteristics have an influence on Instagram consumers’ credibility perceptions and news engagement intentions are lacking. The present study addresses this empirical gap by investigating potential effects of source expertise and source type on source credibility, message credibility, news engagement intentions, and personal involvement regarding political news on Instagram.MethodWe randomly presented participants with political news posts from one of four sources, either the Instagram representation of a fictional news magazine or influencer with or without political expertise. Participants assessed the perceived credibility of the source and the news, their news engagement intentions, and personal involvement.ResultsWe analyzed data from 416 participants. Results showed significant main effects of source expertise on each of the dependent variables. Those were shown to be indirect effects through personal involvement. There were hardly any effects of source type.DiscussionThese results provide new insights into the role of source expertise on credibility perceptions and news engagement intentions, and provide insights into the comparison between influencers and Instagram representations of traditional news magazines. Theoretical implications for future research and practical implications for content creators, users, and SNS platforms are discussed.
Cybersickness as the virtual reality sickness questionnaire (VRSQ) measures it!? –an environment-specific revision of the VRSQ
Authors: Josupeit Judith 
Published: December 2023

Background: Virtual Reality (VR) does not only include the use of stereoscopic images, but also possibilities for an interaction with and participation in a computer-generated environment. However, laboratory studies primarily focus on the first part of the definition only. In this context, comparing results from different VR applications with diverging goals becomes difficult. This is especially true in the field of cybersickness research (visually induced motion sickness in VR), as self-report symptom questionnaires are used. The prominent Simulator Sickness Questionnaire (SSQ) is criticized for the lack of specificity, the double factorial loadings, the outdatedness, and the unrepresentative sample. VR-specific revisions like the Virtual Reality Sickness Questionnaire (VRSQ) address these criticisms but lack generalizability.Methods: The current paper uses a Confirmatory Factor Analysis of the VRSQ with data from three different VR environments and a sample size of N = 244. The environments had different setups, visual complexities, and interaction possibilities. These characteristics influenced the factorial structure of the VRSQ as a moderator. Furthermore, to control for VR-unrelated effects Baseline ratings were taken into account.Results: The Confirmatory Factor Analysis indicated a moderate fit for the global model, but a misspecification for two of the three environments. Only the environment similar to the original VRSQ paper converged with the model.Conclusions: In conclusion, a detailed description of the VR environment is required in scientific method reports. Focusing on VR accessibility for physically impaired in addition to healthy subjects, an added Baseline measurement can address the discriminant validity. Until generalizable VR-specific revisions of the SSQ are validated, the paper suggests using the Δ-SSQ in aggregated raw format.
Are postnatal traumatic events an underestimated cause of porencephalic lesions in dogs and cats?
Authors: Davini Tommaso , Mattei Chiara , La Rosa Claudia , Remelli Carlotta , Specchi Swan , Lionello Elena , Dell’Era Elena , Bernardini Marco 
Published: December 2023

IntroductionPorencephaly is defined as a fluid-filled cavity of variable size in the brain cortex. It is regarded as a congenital condition and is typically considered a developmental or an encephaloclastic defect. Our hypothesis is that postnatal traumatic events in the first few months of life may represent a cause of canine and feline porencephaly that is more common than generally suspected. The aims of this study were to retrospectively investigate porencephaly in a large population of dogs and cats, detect MRI features that might be useful to differentiate postnatal acquired traumatic forms from congenital/perinatal porencephaly, and define the prevalence of seizure activity in porencephalic patients.Materials and methodsThis is a double-center, descriptive, retrospective case series. Databases were searched for cases within a 17-year time span that involve dogs and cats with an MRI-based diagnosis of cerebral cavitary lesions. Animals were included if a complete signalment and an exhaustive MRI of the brain were available. Besides the porencephalic lesions, MRIs of the head were reviewed to detect concomitant musculoskeletal abnormalities.ResultsThirty-two cases involving nine cats and twenty-three dogs were selected. Of all the cases, 21.9% were aged six years or older at the time of diagnosis. All patients in which the neuroanatomical localization was available showed clinical signs of a prosencephalic disorder. Epileptic seizures were observed in 71.8% of cases. A single porencephalic cavity was found in 78.1% of cases. The most affected cerebral lobe was the parietal lobe (n = 20). The defects involved both the grey and white matter in 78.1% of cases. Twenty cases showed concomitant musculoskeletal abnormalities overlying the porencephalic cavities. Fourteen of twenty cases showed evidence of fractures, of which thirteen showed depression of the calvarium and twelve masticatory muscle abnormalities. Of these, seven of fourteen had a history consistent with a head trauma in the first period of life.ConclusionThe recognition of skull fractures and muscular abnormalities closely associated with the porencephalic cavity may support a diagnosis of a postnatal traumatic origin of porencephaly. Therefore, this study highlights the importance of evaluating musculoskeletal structures in the MRIs of the heads of porencephalic cases.
Pengaruh Komitmen Profesional, Pertimbangan Etis, Personal Cost, Reward Terhadap Intensi Internal Whistleblowing (Studi Empiris Pada Opd Kabupaten Siak)
Authors: Hariyani Eka , Putra Adhitya Agri , Wiguna Meilda 
Published: December 2023

Abstrak
Penelitian ini bertujuan untuk menguji dan membuktikan secara empiris: (1) Pengaruh Komitmen Profesional terhadap intensi untuk melakukan internal whistleblowing (2) Pengaruh Pertimbangan Etis terhadap intensi untuk melakukan internal whistleblowing (3) Pengaruh Personal Cost terhadap intensi untuk melakukan internal whistleblowing. (4) Pengaruh Reward terhadap intensi untuk melakukan internal whistleblowing. Sampel penelitian ini adalah 120 orang dari 30 Organisasi Perangkat Daerah Kabupaten Siak. Metode analisis pada penelitian ini adalah analisis regresi berganda. Hasil penelitian ini menunjukkan bahwa (1) Komitmen Profesional berpengaruh terhadap intensi untuk melakukan internal whistleblowing (2) Pertimbangan Etis berpengaruh terhadap intensi untuk melakukan internal whistleblowing (3) Personal Cost berpengaruh terhadap intensi untuk melakukan internal whistleblowing (4) Reward berpengaruh terhadap intensi untuk melakukan internal whistleblowing.
Kata kunci: Intensi Internal Whistleblowing, Komitmen Profesional, Pertimbangan Etis, Personal cost, Reward.
Abstract
This study aims to test and prove empirically: (1) The influence of Professional Commitment to intention to conduct internal whistleblowing (2) The influence of Ethical Considerations on intention to conduct internal whistleblowing (3) The influence of Personal Cost on the intention to conduct internal whistleblowing (4) The influence of Reward on the intention to conduct internal whistleblowing. The sample of this research is 120 people from 30 Organization of Regional Area of â€‹â€‹Siak Regency. The method of analysis in this study is multiple regression analysis. The results of this study indicate that (1) The professional commitment affects the intention to conduct an internal whistleblowing (2) The ethical considerations affects the intention to conduct internal whistleblowing (3) Personal cost affects the intention to conduct internal whistleblowing (4) Reward affects the intention to doing internal whistleblowing
Keywords: Internal Whistleblowing Intent, Professional Commitment, Ethical Considerations, Personal Cost, Reward.
Analisis Pengaruh Koneksi Politik dan Gender Diversity Terhadap Fee Audit
Authors: Yuniarti Rina , Riswandi Pedi , Finthariasari Meilaty 
Published: December 2023

Audit fee merupakan kompensasi yang didapatkan akuntan publik dari perusahaan atas jasa audit yang diberikan. Penelitian ini bertujuan untuk mengetahui apkah koneksi politik dan gender mempengaruhi besarnya biaya audit yang diberikan perusahaan kepada akuntan publik. Data sekunder yang digunakan berbentuk laporan tahunan perusahaan yang go public pada periode 2015-2018. Sampling yang diguankan adalah purposive sampling dengan jumlah data sebanyak 407 perusahaan. Sedangkan variabel atau atribut penelitian diantaranya fee audit digunakan untuk variabel terikat, serta hubungan politik dan gender CEO dipergunakan sebagai variabel bebasnya. Untuk analisis data menggunakan pendekatan regresi linier berganda melalui penggunaan uji asumsi klasik. Hasilnya, hubungan politik dapat meningkatkan biaya audit dan gender CEO tidak signifikan terhadap biaya audit. Batasannya adalah pengungkapan biaya audit dalam laporan tahunan masih bersifat sukarela, yang berakibat pada masih banyaknya perusahaan yang tidak memenuhi kriteria sampel. Variabel yang digunakan dibatasi pada jenis kelamin direksi CEO tanpa melibatkan jenis kelamin dewan komisaris dan komite audit.
Kata kunci: hubungan politik, keragaman gender, biaya audit
Perbandingan Turnaround Time Antara Verifikasi Manual dan Verifikasi Otomatis terhadap Hasil Pemeriksaan Profil Lipid di Laboratorium Klinik Pramita Cabang Pajajaran Kota Bandung
Authors: Barrianti Barrianti , Ally Kafesa , Siti Yumanah 
Published: December 2023

Turnaround Time (TAT) for laboratory services is an indicator of the quality of laboratory services to meet customer satisfaction and as a benchmark for laboratory performance. Laboratory results are very important to be delivered in the shortest possible time for the rapid diagnosis and management of patients. One of the factors that causes the length of TAT in the reporting process at the analytical stage is the verification process of inspection results which is still carried out manually by ATLM personnel. Implementing automatic verification of examination results is one way to overcome the long waiting time (TAT) for laboratory services. The aim of this research is to determinate the TAT of manual verification and automatic verification of lipid profile examination results, and testing the difference in TAT between manual verification and automatic verification of lipid profile examination results at the analytical stage at the Pramita clinical laboratory, Pajajaran branch in Bandung city. The method used in this research is to use descriptive comparative method with a quantitative approach. Based on the research that has been done, the average ± standard deviation TAT for manual verification of the results of lipid profile examination was 112.44 ± 46.02 minutes, while the automatic verification TAT was 68.03 ± 28.07 minutes. The results of the independent sample t-test between TAT manual verification and automatic verification of the lipid profile examination results with a significance value of Sig.(2-tailed) 0.000 <0.05. The conclusion of this research is that TAT verification of lipid profile examination results at the analytical stage decreased after automatic verification was implemented. There is a significant difference in Turnaround Time between manual verification and automatic verification of the results of lipid profile examinations at the analytical stage at the Pramita Clinical Laboratory, Pajajaran branch in Bandung city.