bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for C ii Emission from the First Sample of z ∼ 6 O i Absorption-associated Galaxies with the Atacama Large Millimeter/submillimeter Array
Authors: Wu Yunjing , Cai Zheng , Li Jianan , Finlator Kristian , Neeleman Marcel , Prochaska J. Xavier , Emonts Bjorn H. C. , Zhang Shiwu , Wang Feige , Yang Jinyi , Wang Ran , Fan Xiaohui , Xu Dandan , Golden-Marx Emmet , Keating Laura C. , Hennawi Joseph F. 
Published: November 2023

Abstract
We report the first statistical analyses of [C ii] and dust continuum observations in six strong O i absorber fields at the end of the reionization epoch obtained by the Atacama Large Millimeter/submillimeter Array (ALMA). Combined with one [C ii] emitter reported in Wu et al., we detect one O i-associated [C ii] emitter in six fields. At redshifts of O i absorbers in nondetection fields, no emitters are brighter than our detection limit within impact parameters of 50 kpc and velocity offsets between ±200 km s−1. The averaged [C ii]-detection upper limit is <0.06 Jy km s−1(3σ), corresponding to the [C ii] luminosity of L
[C II]< 5.8 × 107
L
⊙ and the [C ii]-based star formation rate of SFR[C II]<5.5 M
⊙ yr−1. Cosmological simulations suggest that only ∼10−2.5 [C ii] emitters around O i absorbers have comparable SFR to our detection limit. Although the detection in one out of six fields is reported, an order of magnitude number excess of emitters obtained from our ALMA observations supports that the contribution of massive galaxies that caused the metal enrichment cannot be ignored. Further, we also found 14 tentative galaxy candidates with a signal-to-noise ratio of ≈4.3 at large impact parameters (>50 kpc) and having larger outflow velocities within ±600 km s−1. If these detections are confirmed in the future, then the mechanism of pushing metals at larger distances with higher velocities needs to be further explored from the theoretical side.
Titania's Heat Fluxes Revealed by Messina Chasmata
Authors: Beddingfield Chloe B. , Leonard Erin J. , Nordheim Tom A. , Cartwright Richard J. , Castillo-Rogez Julie C. 
Published: November 2023

Abstract
Messina Chasmata is a relatively young tectonic structure on Titania based on cross-cutting relationships, although an absolute age has not been estimated. We investigated lithospheric flexure bounding Messina and found that the terrain along both rims reflects Titania’s thermal properties. We estimate Titania’s heat fluxes to have been 5–12 mW m−2 in this region, assuming that the lithosphere is composed of pure H2O ice without porosity. These estimates are lower if lithospheric porosity and/or NH3–H2O are also present. If Messina is ancient, forming as a result of freeze expansion, then the reflected heat fluxes are consistent with radiogenic heating. However, if Messina is instead young, then an additional heat source is required. In this scenario, perhaps tidal heating associated with the past three-body resonance shared between Titania, Ariel, and Umbriel generated this heat. However, this scenario is unlikely because the amount of tidal heating produced on Titania would have been minimal. Titania’s heat fluxes are notably lower than estimates for Miranda or Ariel, and future work is needed to investigate Umbriel and Oberon to gain a fuller understanding of Uranian moon thermal and orbital histories. Additionally, further constraints on Titania’s more ancient heat fluxes could be obtained by investigating relatively older features, such as some viscously relaxed impact craters.
Peur de (se) souffrir, de (se) voir souffrir et de (se) faire souffrir Quand le moi se dépasse…
Authors: Ostermann Gérard , Lesœurs Guy 
Published: November 2023

La peur de l’autre, de la nature, du destin, de soi-même, de (se) souffrir, de (se) voir souffrir et la peur de (se) faire souffrir entraînent l’angoisse d’abandon avec en filigrane l’effroi devant la mort. Notre société occidentale actuelle semble vouloir estomper ou même éviter les souffrances de tous ordres dont il faudrait se libérer à tout prix afin de pouvoir jouir sans crainte et sans contrainte dans un Eden factice d’où seraient exclus les souffreteux, les vieux, les malades et les déshérités. Il nous a semblé intéressant de questionner cette peur de souffrir en l’apposant, voire en l’opposant, au décentrement de soi-même sur le mode actif-passif, altruiste-égoïste et pronominal. L’effort de « se souffrir » pris dans le sens de « se supporter » est le prérequis à s’imposer avant de s’occuper de la souffrance de l’autre. C’est tout le sens de l’introspection préalable à toute intention psychothérapeutique et même à tout acte de soin. En effet, si l’on n’a pas accompli une introspection longue, ardue et sérieuse, le risque majeur et délétère est de projeter sur l’autre souffrant sa propre angoisse devant la vie et la mort, ce qui majorerait la souffrance collective.
Avantage d’Endocuff vision® deuxième génération dans le dépistage des polypes coliques en pratique courante : cohorte historique prospective comparative
Authors: Benkessou Bouchra , Canard Jean-Marc , Moussali Joseph , El Ouaer Lisa , Contou Jean-François , Godeberge Philippe , Amar Irène , Amaris Juan , Chollet Robert , Costil Vianna , Julien Pierre-Emile , Tarrerias Anne-Laure , Palazzo Laurent , Odinot Jean-Marie , Paucard Alexia 
Published: November 2023

Objectif : Les taux de détection des polypes (TDP) et des adénomes (TDA) sont des indicateurs de qualité de la coloscopie et sont directement corrélés aux risques de cancer d’intervalle et de décès par le cancer du colon. Plus de la moitié des cancers d’intervalle serait liée à des lésions non détectées. Le but de cette étude est de déterminer si Endocuff vision® 2 nde génération (EVC) améliore la détection des adénomes et des polypes coliques dans la pratique courante. Méthodes : C’est une étude monocentrique non randomisée, en ouvert, comparant les données préexistantes de la coloscopie classique, obtenues dans la pratique courante de l’établissement dans la période du 1 er juin au 22 juillet 2017 (période rétrospective) sur 515 sujets sans EVC, et 521 patients avec le dispositif EVC du 18 octobre 2018 au 30 septembre 2019, après information et recueil du consentement (période prospective). Ces deux périodes ont été consécutives afin de limiter le biais de sélection. Le critère de jugement principal correspondait à la détection du taux d’adénomes, réalisée en coloscopie classique avec ou sans EVC sur des patients adultes. L’essai a été analysé par un test de comparaison de proportion entre les groupes pour données indépendantes sur le critère principal. Résultats : Le taux de détection d’au moins un adénome est augmenté avec le dispositif Endocuff® de 16,83 % à 21,11 % (P=0,036). Une meilleure préparation avec un score Boston = 9, améliore la détection des adénomes de 19,76 % à 26,68 % (P=0,003). Avec l’EVC, un temps de progression inférieur à 5 mn est préférable pour améliorer le taux de détection des adénomes (RR = 1,141 (1,130 to 1,752), P=0,0013), et un temps de retrait entre 6 et 10 mn (RR=1,449 (1,161 to 1,810, P=0,0027). Conclusion : L’utilisation du système Endocuff® améliore de façon significative la détection des adénomes pendant la coloscopie chez les patients ayant des antécédents personnels ou familiaux de polypes et de cancer et chez les patients ayant un BMI > à 30 ainsi que le temps de progression. Il est indispensable dans la détection des adénomes pendant la coloscopie. Il n’y a pas eu de complication associée [3, 5]. N°d’enregistrement de l’essai : NCT NCT03758872
La success story des vidéastes
Authors: Caceres Judith 
Published: November 2023

Plus qu’un lieu d’expression, la plateforme YouTube est devenue un lieu d’exposition permettant à certains créateurs de contenus de bénéficier d’une certaine notoriété, jusqu’à parfois être érigés au rang de « star ». Le cinéma ou la télévision ne sont plus les seuls à faire naître des stars : il faut désormais aussi compter avec YouTube . Cet article se propose d’interroger le succès de ces nouvelles vedettes issues du web. À partir du discours de la presse magazine, nous proposons une réflexion sur la notoriété des créateurs de contenus vidéo et de dessiner en creux l’image de ces nouvelles célébrités issues du web.
La Star Ac’ revue et corrigée par les réseaux socio-numériques ?
Authors: Alexis Lucie 
Published: November 2023

Cet article aborde le retour à l’antenne de la Star Academy sur TF1, en 2022, et met au jour la manière dont la chaîne, la production et les candidats l’ont envisagé au regard des nouvelles modalités de constitution du genre télé-réalité qui s’actualise désormais systématiquement avec les réseaux socio-numériques. D’abord, la communication en amont de l’émission sur les médias sociaux s’est fortement construite par des modalités discursives visant à la patrimonialisation du programme et a consisté à rappeler la première vie de la Star Academy. Ensuite, la production a capitalisé sur l’« émission-marque » en reprenant une mécanique qui avait déjà fonctionné. Enfin, la participation des spectateurs via les réseaux socio-numériques constitue la véritable augmentation du programme.
Cost-Effectiveness Analysis of Light Adjustable Lens Compared to Monofocal Intraocular Lens in Cataract Surgery
Authors: Nishihara Taiki W. , Hu Jenny Q. , Buchholz Rhiannon D. , Murphy James D. , Afshari Natalie A. 
Published: November 2023

Purpose:
To analyze the cost-effectiveness of the Light Adjustable Lens (LAL; RxSight) in comparison to a monofocal intraocular lens (IOL) for individuals undergoing cataract surgery in both eyes.

Methods:
A cost-effectiveness analysis was performed using a Markov model that simulated the patient outcomes and costs associated with undergoing cataract surgery with the LAL or monofocal IOL. Cost-effectiveness was determined using the incremental cost-effectiveness ratio (ICER), a measure that quantifies the incremental cost in dollars per quality-adjusted life year (QALY) gained. Treatments with the ICER below the willingness-to-pay threshold (WTP) of $50,000/QALY were considered cost-effective. The model was also evaluated for the impact of uncertainties in parameters using one-way sensitivity and probabilistic sensitivity analyses.

Results:
The cost-effectiveness analysis showed that the LAL is cost-effective compared to monofocal IOLs in patients undergoing cataract surgery, with ICERs of $9,792/QALY (health care perspective) and $10,072/QALY (societal perspective) both significantly below the WTP. The model was most sensitive to patient age, market cost of the LAL, and proportion of patients with residual astigmatism following cataract surgery. The probabilistic sensitivity analysis showed that cataract surgeries in patients starting at age 65 years were cost-effective in 94% of the simulations at a WTP of $50,000/QALY.

Conclusions:
From both health care and societal perspectives, the study shows cataract surgeries performed with the LAL are cost-effective when compared to those performed with a monofocal IOL. More studies are needed to compare the LAL to other premium lenses that also provide patients with excellent visual outcomes at a higher cost.

[
J Refract Surg
. 2023;39(11):777–782.]
Structural and functional connectivity of the whole brain and subnetworks in individuals with mild traumatic brain injury: predictors of patient prognosis
Authors: Huang Sihong , Han Jungong , Zheng Hairong , Li Mengjun , Huang Chuxin , Kui Xiaoyan , Liu Jun 
Published: November 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202407000-00035/figure1/v/2023-11-20T171125Z/r/image-tiff

Patients with mild traumatic brain injury have a diverse clinical presentation, and the underlying pathophysiology remains poorly understood. Magnetic resonance imaging is a non-invasive technique that has been widely utilized to investigate neurobiological markers after mild traumatic brain injury. This approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury. Graph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and function. However, most previous mild traumatic brain injury studies using graph theory have focused on specific populations, with limited exploration of simultaneous abnormalities in structural and functional connectivity. Given that mild traumatic brain injury is the most common type of traumatic brain injury encountered in clinical practice, further investigation of the patient characteristics and evolution of structural and functional connectivity is critical. In the present study, we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain injury. In this longitudinal study, we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 weeks of injury, as well as 36 healthy controls. Resting-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network analysis. In the acute phase, patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention network. More than 3 months of follow-up data revealed signs of recovery in structural and functional connectivity, as well as cognitive function, in 22 out of the 46 patients. Furthermore, better cognitive function was associated with more efficient networks. Finally, our data indicated that small-worldness in the acute stage could serve as a predictor of longitudinal changes in connectivity in patients with mild traumatic brain injury. These findings highlight the importance of integrating structural and functional connectivity in understanding the occurrence and evolution of mild traumatic brain injury. Additionally, exploratory analysis based on subnetworks could serve a predictive function in the prognosis of patients with mild traumatic brain injury.
A Rare Cause of Encephalopathy Post Renal Transplant: BK Polyoma Virus Encephalitis
Authors: Jeemon Gladwin , Ganesh Kartik , Madavana V Vidya , Abraham M. Abi 
Published: November 2023

Abstract
BK polyoma virus (BKV) belongs to Polyomaviridae family. It is a double-stranded DNA virus. Only a few cases of BKV–associated neurological disease in renal transplant recipients have been reported. BKV related central nervous system (CNS) infection may often remain unrecognized in immunocompromised patients. Here, we are reporting a case of BKV encephalitis post renal transplantation for the awareness of all physicians regarding this entity.
Efficacy of PD-1/PD-L1 inhibitors in advanced hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Peng Tzu-Rong , Yang Li-Jou , Wu Ta-Wei 
Published: November 2023

ABSTRACT

Objectives:
This study aimed to investigate the efficacy and safety of programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in patients with advanced hepatocellular carcinoma (HCC).

Materials and Methods:
PubMed, EMBASE, and the Cochrane Library were searched for articles published until November 2022. Studies reporting the efficacy of PD-1/PD-L1 inhibitors in patients with advanced HCC were eligible for inclusion. The outcomes were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and ≥ Grade 3 treatment-related adverse events (TrAEs).

Results:
Fourteen trials with 4515 patients with HCC were included. Our results showed that treatment with PD-1/PD-L1 inhibitors was associated with better ORR and DCR than that with control (placebo or sorafenib or lenvatinib) (odds ratio [OR], 3.89; 95% confidence interval (CI), 2.55–5.95 and OR, 1.47; 95% CI, 1.11–1.95, respectively). The overall hazard ratio (HR) of PFS and OS were 0.66 (95% CI 0.56–0.78) and 0.65 (95% CI 0.55–0.77), respectively. In subgroup analysis, PD-1/PD-L1 inhibitor combination therapy had an advantage in terms of PFS (HR: 0.57 vs. 0.81) compared to that of PD-1/PD-L1 monotherapy. The incidence of grade 3–5 TrAEs was not significantly higher with PD-1/PD-L1 inhibitors than that with the control (OR, 1.12; 95% CI, 0.70–1.81). However, the combination of PD-1inhibitor with higher incidence of Grade 3–5 TrAEs (OR: 2.04, 95% CI 0.66–6.32) than the combination PD-L1 inhibitor (OR: 0.95, 95% CI 0.50–1.81).

Conclusion:
The combination of PD-1/PD-L1 inhibitors and targeted agents significantly improved the clinical outcomes in patients with advanced HCC. However, the incidence of Grade 3–5 TrAEs with PD-1 inhibitor combination therapy was higher than the combination PD-L1 inhibitor.
Development of Flipbooks Based on Guided Inquiry Models to Train Science Process Skills of Junior High School Students on Temperature and Heat Materials
Authors: Awaliyah Masna , Widodo Wahono , Haryono Eko 
Published: November 2023

Objective: This development aims to produce a flipbook-based guided inquiry learning model to train science process skills that are feasible in terms of validity, practicality, and effectiveness. Method: The type of research used is development research. The development model used is the 4D model (define, design, develop, and disseminate). The assessment instrument used in this study consisted of learning device validation sheets and science process skills tests. Results: Based on the results of data analysis, it can be concluded that digital-based flipbooks obtain an average validation in the valid category. These results indicate that flipbooks can be used as learning media. Novelty: The novelty of this research is an inquiry-based feature on flipbooks about temperature and heat, which can train students' science process skills. In addition, the developed inquiry-based Flipbook is also a digital flipbook.
The Influence of Industrial Work Practice Experience-Career Information on Student Competence with Work Motivation as an Intervening Variable in Bachelor of Electrical Engineering Education Graduates
Authors: Achmad Fendi , Kholis Nur , Dianawati Roswina , Rahmatullah Daeng , Nugroho Yuli Sutoto , Uulaa Rizki Fitri Rahima 
Published: November 2023

Objective: This research aims to analyze (1) the direct influence of industrial work practice experience on work motivation, (2) the direct influence of industrial work practice experience on competency, (3) the indirect influence of industrial work practice experience on work readiness through work motivation; (4) the direct influence of career information on work motivation; (5) the direct influence of career information on competency; (6) indirect influence of career information on competence through work motivation; and (7) the direct influence of work motivation on the competency of undergraduate Electrical Engineering Education students at the Faculty of Engineering. Method: The quantitative approach used in this research is the path analysis model. The population in this study were all undergraduate students of Electrical Engineering Education at the Faculty of Engineering, with a total population of 194 graduate students. Results: This research concluded that (1) industrial work practice experience has a direct effect on work motivation by 16%; (2) industrial work practice experience has a direct effect on competency by 16.81%; (3) industrial work practice experience has an indirect effect on competence through work motivation of 1.25%; (4) career information has a direct effect on work motivation by 7.29%; and (5) career information has a direct effect on competency by 4.41%. Novelty: Internship experience has a direct influence on work motivation and competence. This means that the Department of Electrical Engineering is expected to properly monitor and evaluate the implementation of students' industrial work practices in industry. Monitoring can be done through monitoring instruments, which must be filled in by internal supervisors and external supervisors, with the hope of increasing the effectiveness of implementing industrial work practices. Apart from that, the industry is expected to be able to optimize the role of students during industrial work practices so that they gain knowledge and experience that influences work motivation and competence.
Strategic Management Practices on Performance of Family-Owned Firms in the Manufacturing Sector in Kenya
Authors: Rambeka Z. , Odollo L. 
Published: November 2023

Purpose: Majority of the small and medium-size enterprises (SMEs) in Kenya are conventionally family businesses owing to their initial source of capital, ownership and day-to-day operations. Kenya’s economy represents a feudal-like family economy dominated by a few well-capitalized family-owned units at both the top and mid-tier. Strategic management practices are usually geared towards increasing managerial efficiency and effectiveness so as to increase the current and future operations. The purpose of this study was to explore the effect of strategic management practices on the performance of family-owned manufacturing firms in Nairobi City County, Kenya. The specific objectives of the study included: environmental scanning, strategy formulation, strategy implementation and strategy evaluation and monitoring.
Methodology: The study adopted descriptive research design using purposive sampling strategy targeting 4 heads of departments per firm from 20 firms yielding a total of 80 respondents. Structured questionnaires were used to collect primary data. Profitability ratio was collected using a secondary data collection sheet. Primary data was analyzed using SPSS version 25. Data was analyzed both descriptively as well as inferentially using and presented using statistical distribution tables.
Findings: The results established that environmental scanning, strategy formulation, strategy implementation and strategy evaluation and monitoring positively and significantly affect the organizational performance of family-owned manufacturing firms. The results hence indicate that increasing each of the variable with one-unit results to increase in organizational performance of these firms with their respective beta values.
Unique Contribution to Theory, Practice and Policy: The study was anchored on the following theories: agency theory, transaction cost theory, transformational and stewardship theories. The study recommends that the family-owned manufacturing firms operating in Nairobi City County, Kenya to enhance their environmental scanning, strategy formulation, strategy implementation and strategy evaluation and monitoring practices since the practices positively and significantly affects organizational performance.