bluuebunny/crossref_metadata_2025_split huggingface dataset:
The feasibility and inevitability of stealth attacks
Authors: Tyukin Ivan Y , Higham Desmond J , Bastounis Alexander , Woldegeorgis Eliyas , Gorban Alexander N 
Published: October 2023

Abstract
We develop and study new adversarial perturbations that enable an attacker to gain control over decisions in generic Artificial Intelligence (AI) systems including deep learning neural networks. In contrast to adversarial data modification, the attack mechanism we consider here involves alterations to the AI system itself. Such a stealth attack could be conducted by a mischievous, corrupt or disgruntled member of a software development team. It could also be made by those wishing to exploit a ‘democratization of AI’ agenda, where network architectures and trained parameter sets are shared publicly. We develop a range of new implementable attack strategies with accompanying analysis, showing that with high probability a stealth attack can be made transparent, in the sense that system performance is unchanged on a fixed validation set which is unknown to the attacker, while evoking any desired output on a trigger input of interest. The attacker only needs to have estimates of the size of the validation set and the spread of the AI’s relevant latent space. In the case of deep learning neural networks, we show that a one-neuron attack is possible—a modification to the weights and bias associated with a single neuron—revealing a vulnerability arising from over-parameterization. We illustrate these concepts using state-of-the-art architectures on two standard image data sets. Guided by the theory and computational results, we also propose strategies to guard against stealth attacks.
Oscillatory and regularized shock waves for a dissipative Peregrine–Boussinesq system
Authors: Brudvik-Lindner Larkspur , Mitsotakis Dimitrios , Tzavaras Athanasios E 
Published: October 2023

Abstract
We consider a dissipative, dispersive system of the Boussinesq type, which describes wave phenomena in scenarios where dissipation plays a significant role. Examples include undular bores in rivers or oceans, where turbulence-induced dissipation significantly influences their behavior. In this study, we demonstrate that the proposed system admits traveling wave solutions known as diffusive-dispersive shock waves. These solutions can be categorized as oscillatory and regularized shock waves, depending on the interplay between dispersion and dissipation effects. By comparing numerically computed solutions with laboratory data, we observe that the proposed model accurately captures the behavior of undular bores over a broad range of phase speeds. Traditionally, undular bores have been approximated using the original Peregrine system, which, even though it doesn’t possess these as traveling wave solutions, tends to offer accurate approximations within suitable time scales. To shed light on this phenomenon, we demonstrate that the discrepancy between the solutions of the dissipative Peregrine system and the non-dissipative counterpart is proportional to the product of the dissipation coefficient and the observation time.
Earmarked Funding and the Performance of International Organizations: Evidence from Food and Agricultural Development Agencies
Authors: Reinsberg Bernhard 
Published: October 2023

Abstract
How do funding structures affect the performance of international organizations (IOs)? Considering the rapid growth of earmarked funding over the past decade, the need to address this question has become a matter of urgency. To answer this question, I divide IO performance into outcome performance (i.e., achieving results that are relevant and sustainable) and process performance (i.e., having systems, rules, and practices that enable IOs to achieve self-defined goals effectively, efficiently, and responsively). Drawing on the principal−agent framework and studies of organizational behavior, I derive expectations about how earmarked funding can affect those performance dimensions. To empirically examine these expectations, I rely on qualitative case studies of three major IOs in food and agricultural development—Food and Agricultural Organization, International Fund for Agricultural Development, and World Food Program—using semi-structured interviews with IO staff and evaluation reports from multiple sources. I find that earmarked funding undermines performance, albeit not uniformly across performance areas and organizational contexts. I highlight the need for future research that considers how funding structures, institutional structures, and organizational behavior interact to affect organizational performance.
Virological outcomes of various first-line ART regimens in patients harbouring HIV-1 E157Q integrase polymorphism: a multicentre retrospective study
Authors: Uno Shunsuke , Gatanaga Hiroyuki , Hayashida Tsunefusa , Imahashi Mayumi , Minami Rumi , Koga Michiko , Samukawa Sei , Watanabe Dai , Fujii Teruhisa , Tateyama Masao , Nakamura Hideta , Matsushita Shuzo , Yoshino Yusuke , Endo Tomoyuki , Horiba Masahide , Taniguchi Toshibumi , Moro Hiroshi , Igari Hidetoshi , Yoshida Shigeru , Teshima Takanori , Nakajima Hideaki , Nishizawa Masako , Yokomaku Yoshiyuki , Iwatani Yasumasa , Hachiya Atsuko , Kato Shingo , Hasegawa Naoki , Yoshimura Kazuhisa , Sugiura Wataru , Kikuchi Tadashi 
Published: October 2023

Abstract

Background
Integrase strand transfer inhibitors (INSTIs) are recommended as first-line ART for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated mutation E157Q, a highly prevalent (2%–5%) polymorphism of the HIV-1 (human immunodeficiency virus type 1) integrase gene, has limited data on optimal first-line ART regimens. We assessed the virological outcomes of various first-line ART regimens in PLWH with E157Q in real-world settings.

Methods
A multicentre retrospective observational study was conducted on PLWH who underwent integrase genotypic drug-resistance testing before ART initiation between 2008 and 2019 and were found to have E157Q. Viral suppression (&lt;50 copies/mL) rate at 24 and 48 weeks, time to viral suppression and time to viral rebound (≥100 copies/mL) were compared among the first-line ART regimens.

Results
E157Q was detected in 167 (4.1%) of 4043 ART-naïve PLWH. Among them, 144 had available clinical data after ART initiation with a median follow-up of 1888 days. Forty-five started protease inhibitors + 2 NRTIs (PI group), 33 started first-generation INSTI (raltegravir or elvitegravir/cobicistat) + 2 NRTIs (INSTI-1 group), 58 started once-daily second-generation INSTI (dolutegravir or bictegravir) + 2 NRTIs (INSTI-2 group) and eight started other regimens. In the multivariate analysis, the INSTI-2 group showed similar or favourable outcomes compared with the PI group for viral suppression rates, time to viral suppression and time to viral rebound. Two cases in the INSTI-1 group experienced virological failure.

Conclusions
The general guideline recommendation of second-generation INSTI-based first-line ART for most PLWH is also applicable to PLWH harbouring E157Q.
Early attainment of isavuconazole target concentration using an increased loading dose in critically ill patients with extracorporeal membrane oxygenation
Authors: Hatzl Stefan , Kriegl Lisa , Posch Florian , Schilcher Gernot , Eller Philipp , Reisinger Alexander , Grinschgl Yvonne , Muhr Tina , Meinitzer Andreas , Hoenigl Martin , Krause Robert 
Published: October 2023

Abstract

Background
In critically ill patients with extracorporeal membrane oxygenation (ECMO) attainment of target concentration of isavuconazole is delayed using the routine loading dose.

Objectives
We investigated the influence of increasing the first loading dose of isavuconazole on plasma concentrations in critically ill patients treated with ECMO.

Methods
Fifteen patients were included in this study, and isavuconazole concentrations were measured at several timepoints starting 2 h after the first isavuconazole dose up to 168 h. By interim analysis of isavuconazole concentrations and meticulous screening for adverse events, the first loading dose was stepwise increased from 200 to 300 mg, and finally to 400 mg.

Results
Seven of 15 patients (47%) received standard isavuconazole loading dosage with 200 mg as the first dose, 3/15 (20%) received 300 mg, and 5/15 (33%) received 400 mg isavuconazole as the first dose, followed by subsequent standard dosing in all patients. In patients receiving 400 mg as the first dose all isavuconazole concentrations were significantly higher at timepoints up to the first 24 h, resulting in higher proportions of isavuconazole concentrations ≥1 mg/L compared with patients with other loading dosages. In timepoints ≥24 h after isavuconazole initiation all patient groups reached comparable plasma concentrations, regardless of the first loading dose regimen. We did not observe concentrations above ≥5 mg/L or any adverse events related to isavuconazole administration.

Conclusions
In critically ill patients with ECMO the 400 mg loading dose of isavuconazole resulted in immediate median isavuconazole plasma concentrations ≥1 mg/L and remained constant above this threshold after the first loading dose.
A Versatile and Reproducible Cryo-sample Preparation Methodology for Atom Probe Studies
Authors: Woods Eric V , Singh Mahander P , Kim Se-Ho , Schwarz Tim M , Douglas James O , El-Zoka Ayman A , Giulani Finn , Gault Baptiste 
Published: October 2023

Abstract
Repeatable and reliable site-specific preparation of specimens for atom probe tomography (APT) at cryogenic temperatures has proven challenging. A generalized workflow is required for cryogenic specimen preparation including lift-out via focused ion beam and in situ deposition of capping layers, to strengthen specimens that will be exposed to high electric field and stresses during field evaporation in APT and protect them from environment during transfer into the atom probe. Here, we build on existing protocols and showcase preparation and analysis of a variety of metals, oxides, and supported frozen liquids and battery materials. We demonstrate reliable in situ deposition of a metallic capping layer that significantly improves the atom probe data quality for challenging material systems, particularly battery cathode materials which are subjected to delithiation during the atom probe analysis itself. Our workflow design is versatile and transferable widely to other instruments.
Reconsidering Vestibular/Ocular Motor Screening Cutoff Scores for Concussion
Authors: Weightman Margaret M , King Laurie A , Fino Peter C , Dibble Leland E , Pelo Ryan , Michielutti Patrick G , Richard Holly , Parrington Lucy , Lester Mark E , Hoppes Carrie W 
Published: October 2023

ABSTRACT

Introduction
Vestibular/Ocular Motor Screening (VOMS) is often part of a comprehensive evaluation to identify acute mild traumatic brain injury. Most of the reports describe the use of the VOMS in adolescents/young adults and not in older adults or military service members. The purpose of this study was to describe VOMS findings in healthy civilians and active duty military service members up to the age of 50 years.

Materials and Methods
Seventy-seven healthy civilians between 18 and 50 years of age (22 males, age 31.8 [9.0] years) participated across three sites in addition to 40 healthy active duty service members (25 males, age 27.5 [4.9] years) from one site. Demographics, Neurobehavioral Symptom Inventory scores, mean near point convergence (NPC) distance, and Total Symptom Change (TSS) scores from the VOMS were evaluated.

Results
For civilians, the group mean NPC distance was 4.98 (3.8) cm. For military service members, the group mean NPC distance was 6.17 (4.57) cm. For civilians, the mean TSS was 1.2 (2.3) with 53.2% reporting 0 TSS, 27.3% reporting one TSS, and 19.5% reporting two or more TSS. For military service members, the mean TSS was 0.20 (0.72) with 92.5% reporting 0 TSS, 0% reporting one TSS, and 7.5% reporting two or more TSS. Age did not correlate with the mean NPC distance and TSS in healthy civilians and active duty military service members.

Conclusions
Reconsideration of the Military Acute Concussion Evaluation, Version 2 cutoff value for abnormal mean NPC distance may be warranted to improve diagnostic accuracy in both civilian and military adult populations. Similarly, re-evaluating criteria for interpreting the TSS results of the VOMS, specifically in civilians, may be warranted.
Spectroscopic searches for evolutionary orbital period changes in WR+OB binaries: the case of V444 Cyg
Authors: Shaposhnikov I , Cherepashchuk A , Dodin A , Postnov K 
Published: October 2023

ABSTRACT
We present the results of new photometric and spectroscopic observations of the WN5+O6 binary V444 Cyg and a detailed analysis of extant spectroscopy and photometry. Using elements of the spectroscopic orbit and assuming e ≈ 0, i ≈ 78° we determined the masses and orbit sizes of the components of V444 Cyg as MO6 ≈ 26.4 M⊙, MWN5 ≈ 10.7 M⊙, aO6 ≈ 10.6 R⊙, aWN5 ≈ 26.1 R⊙. Based on new and archival light curves and using the Hertzsprung method, we improved the photometric estimate of the secular increase rate of the orbital period in V444 Cyg, obtaining $\dot{P}_{\mathrm{ph}} = 0.119\pm 0.003$ s yr−1. From a comparison of the new and archival radial velocity curves of V444 Cyg, we independently derived the secular orbital period change rate as $\dot{P}_{\mathrm{sp}} = 0.147\pm 0.032$ s yr−1, in agreement with the photometric $\dot{P}_{\mathrm{ph}}$. The obtained secular increase rate of the binary orbital period $\dot{P}$ and the mean radii of the components enabled us to estimate the stellar wind mass-loss rate from the WR star as $\dot{M}_{\mathrm{WN5}} = -(6.0\pm 0.4)\times 10^{-6}~{\rm M}_{\odot }\mbox{ yr}^{-1}$.
CaeNDR, the Caenorhabditis Natural Diversity Resource
Authors: Crombie Timothy A , McKeown Ryan , Moya Nicolas D , Evans Kathryn S , Widmayer Samuel J , LaGrassa Vincent , Roman Natalie , Tursunova Orzu , Zhang Gaotian , Gibson Sophia B , Buchanan Claire M , Roberto Nicole M , Vieira Rodolfo , Tanny Robyn E , Andersen Erik C 
Published: October 2023

Abstract
Studies of model organisms have provided important insights into how natural genetic differences shape trait variation. These discoveries are driven by the growing availability of genomes and the expansive experimental toolkits afforded to researchers using these species. For example, Caenorhabditis elegans is increasingly being used to identify and measure the effects of natural genetic variants on traits using quantitative genetics. Since 2016, the C. elegans Natural Diversity Resource (CeNDR) has facilitated many of these studies by providing an archive of wild strains, genome-wide sequence and variant data for each strain, and a genome-wide association (GWA) mapping portal for the C. elegans community. Here, we present an updated platform, the Caenorhabditis Natural Diversity Resource (CaeNDR), that enables quantitative genetics and genomics studies across the three Caenorhabditis species: C. elegans, C. briggsae and C. tropicalis. The CaeNDR platform hosts several databases that are continually updated by the addition of new strains, whole-genome sequence data and annotated variants. Additionally, CaeNDR provides new interactive tools to explore natural variation and enable GWA mappings. All CaeNDR data and tools are accessible through a freely available web portal located at caendr.org.
Green and blue infrastructure (GBI) and urban nature-based solutions (NbS) contribution to human and ecological well-being and health
Authors: Pinto Luis Valenca , Inácio Miguel , Pereira Paulo 
Published: October 2023

Abstract
The article explores the contributions of urban green and blue infrastructure (UGBI) and nature-based solutions (NbS) to enhance human and ecological well-being and health in urban areas. It delves into the concepts of UGBI and NbS, highlighting their importance in creating sustainable and liveable cities. We consider UGBI natural elements in the urban environment, grouped into different typologies. NbS are considered solutions, or actions, to promote environmental and human health based on the use of UGBI. The assessment was done under the umbrella of human and ecosystem health, linking well-being dimensions from the Common International Classification of Ecosystem Services—freedom of choice, social relations, mental health, physical health, food security and physical security—with the United Nations’ Sustainable Development Goals, showing a link with 12 of the 15 goals. The article presents non-exhaustive lists of UGBI types and NbS actions linked to well-being dimensions. We assess ecosystem services provided by GBI and NbS and the implications of incorporating these solutions in urban environments for human and ecosystem health and the future of healthy and liveable cities.
Doing Qualitative Analysis and Interpretation
Authors: Faulkner Sandra L. , Atkinson Joshua D. 
Published: October 2023

Abstract
This chapter covers the basics of doing qualitative analysis and interpretation from creating transcripts to code books and the coding process. The authors provide step-by-step guidelines for coding and thematic analysis that should have readers ready to code their own work and justify the coding decisions they make. The authors discuss how to do different types of interview transcription and the special considerations a researcher needs to work through. This chapter discusses the differences between a code, category, and theme, something that can be confusing for beginning qualitative researchers, and by the end of the chapter, the authors want readers to learn to trust in the process of data analysis.
Introduction
Authors: Lewis David 
Published: October 2023

Abstract
This is the introduction of The Paradoxes of Time Travel. In The Paradoxes of Time Travel Lewis argues that time travel as it is imagined in certain science fiction narratives is a genuine possibility. In his own words, Lewis aimed, ‘(1) to solve a philosophical problem hitherto largely ignored or casually mis-solved by philosophers […]; (2) to introduce the layman to various topics in metaphysics, since our problem turns out to connect with many more familiar ones; and (3) to show several of my favorite doctrines and methods in metaphysics’. In the course of his 6 lectures, Lewis lays out his Quinean four-dimensionalist metaphysics and explains how our ordinary concept of person allows for causal loops. This requires a notion of ‘reverse causation’ which Lewis explains by analysing causation in counterfactual terms. Finally, Lewis elaborates on the sense in which we can and cannot be intelligibly said to be free to change the past.
Mapping Exercise
Authors: Lewis David 
Published: October 2023

Abstract
This is the second chapter of The Paradoxes of Time Travel. In The Paradoxes of Time Travel Lewis argues that time travel as it is imagined in certain science fiction narratives is a genuine possibility. In his own words, Lewis aimed, ‘(1) to solve a philosophical problem hitherto largely ignored or casually mis-solved by philosophers […]; (2) to introduce the layman to various topics in metaphysics, since our problem turns out to connect with many more familiar ones; and (3) to show several of my favorite doctrines and methods in metaphysics’. In the course of his 6 lectures, Lewis lays out his Quinean four-dimensionalist metaphysics and explains how our ordinary concept of person allows for causal loops. This requires a notion of ‘reverse causation’ which Lewis explains by analysing causation in counterfactual terms. Finally, Lewis elaborates on the sense in which we can and cannot be intelligibly said to be free to change the past.
Personal Identity and Personal Time
Authors: Lewis David 
Published: October 2023

Abstract
This is the third chapter of The Paradoxes of Time Travel. In The Paradoxes of Time Travel Lewis argues that time travel as it is imagined in certain science fiction narratives is a genuine possibility. In his own words, Lewis aimed, ‘(1) to solve a philosophical problem hitherto largely ignored or casually mis-solved by philosophers […]; (2) to introduce the layman to various topics in metaphysics, since our problem turns out to connect with many more familiar ones; and (3) to show several of my favorite doctrines and methods in metaphysics’. In the course of his 6 lectures, Lewis lays out his Quinean four-dimensionalist metaphysics and explains how our ordinary concept of person allows for causal loops. This requires a notion of ‘reverse causation’ which Lewis explains by analysing causation in counterfactual terms. Finally, Lewis elaborates on the sense in which we can and cannot be intelligibly said to be free to change the past.
Reversed Causation
Authors: Lewis David 
Published: October 2023

Abstract
This is the fourth chapter of The Paradoxes of Time Travel. In The Paradoxes of Time Travel Lewis argues that time travel as it is imagined in certain science fiction narratives is a genuine possibility. In his own words, Lewis aimed, ‘(1) to solve a philosophical problem hitherto largely ignored or casually mis-solved by philosophers […]; (2) to introduce the layman to various topics in metaphysics, since our problem turns out to connect with many more familiar ones; and (3) to show several of my favorite doctrines and methods in metaphysics’. In the course of his 6 lectures, Lewis lays out his Quinean four-dimensionalist metaphysics and explains how our ordinary concept of person allows for causal loops. This requires a notion of ‘reverse causation’ which Lewis explains by analysing causation in counterfactual terms. Finally, Lewis elaborates on the sense in which we can and cannot be intelligibly said to be free to change the past.
Rational Beliefs: Kinematics
Authors: Lewis David 
Published: October 2023

Abstract
This is the third chapter of Confirmation Theory. Confirmation Theory is a book manuscript that Lewis wrote in 1969 on the basis of a course he’d given at UCLA. He submitted the manuscript to Harvard University Press who expressed an interest. It consists of seven chapters covering intensional semantics, probability measures, rational belief, principles of indifference and Carnap and Hintikka’s inductive systems. The work was intended to be accessible to students with, as Lewis put it, ‘hairy high-school algebra’. He described the manuscript to Richard Jeffrey as ‘Mathematically self-contained, with proofs for the major theorems’. Lewis originally envisaged that Carnap’s The Continuum of Inductive Methods (1952) be used as an accompanying text. Lewis focused on Carnap and Hintikka in particular because he believed that their work constituted the attractive core of what competing theories of confirmation had in common.
Principles of Indifference
Authors: Lewis David 
Published: October 2023

Abstract
This is the fifth chapter of Confirmation Theory. Confirmation Theory is a book manuscript that Lewis wrote in 1969 on the basis of a course he’d given at UCLA. He submitted the manuscript to Harvard University Press who expressed an interest. It consists of seven chapters covering intensional semantics, probability measures, rational belief, principles of indifference and Carnap and Hintikka’s inductive systems. The work was intended to be accessible to students with, as Lewis put it, ‘hairy high-school algebra’. He described the manuscript to Richard Jeffrey as ‘Mathematically self-contained, with proofs for the major theorems’. Lewis originally envisaged that Carnap’s The Continuum of Inductive Methods (1952) be used as an accompanying text. Lewis focused on Carnap and Hintikka in particular because he believed that their work constituted the attractive core of what competing theories of confirmation had in common.
Reply to R.M. Adams, “Actualism and Thisness” (1979)
Authors: Lewis David 
Published: October 2023

Abstract
In this short paper, dating from 1979, Lewis considers Robert Adams’ actualism and haecceitism and argues against them. Lewis’s objections rely on distinguishing possibilities from possible worlds, structurally indiscernible twins, and the possibility which contains a person exactly intermediate between Lewis and Adams.