bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective encapsulation of noble and small gases and molecules by tubularene molecule
Authors: Weinert Christopher , Ćoćić Dušan , Puchta Ralph , van Eldik Rudi 
Published: December 2023

AbstractBased on computational chemistry calculations (ωB97XD/def2‐tzvp//ωB97XD/def2‐svp/svpfit+ZPE(ωB97XD/def2‐svp/svpfit)), binding energy of tubular[3,6,6,6]arene to accommodate noble gases and a series of 29 small gases were calculated. Based on the gained results, Rn (−17.52 kcal/mol) from the series of noble gases is best suited to be accommodated. In the series of noble gases, the binding energy increases linearly with increasing gas radii. From the series of 29 small guests, IF3 and C2I2 (~ −23 kcal/mol) have the best proclivity to be most effectively accommodated in the tubularene, with other 26 exhibiting favorable encapsulation energies on various scales depending on their voluminosity and structure, and only NI3 with the unfavorable complexation energy of 13.87 kcal/mol. Investigated gases, depending on the size, are placed at the different position inside the tube‐like cavity of the tubularene. The structure of the tubularene, independent of the hosted guest species, has remained very rigid, with its atom's rearrangements withing an error margin.
Efficient Recovery of Valuable Resources from Construction and Demolition Waste Towards Circular Economy in Construction Industry—Sustainability Assessment and a Case Study
Authors: Ozcelikci Emircan , Aldemir Alper , Sahmaran Mustafa 
Published: December 2023

AbstractConsiderably high amounts of CO2 release to the atmosphere trigger global warming. Although there are several methods to reduce the level of CO2 release, the extent is still very limited and recently-growing awareness of sustainabil-ity/global warming have been pushing the entire construction industry to seek alternative methods for rigorously lowering/eliminating the level of CO2. The key strategic objective of the study is to develop eco-friendly/innovative, 100% CDW-based construction materials and demountable structural systems. This study aims to achieve higher levels of circularity in civil engineering materials/structures, contributing to the reduction/elimination of CO2 emissions much more rigorously through the following key objectives: (i) Upgrading CDW recycling/reuse efficiency by capturing CO2 from the atmosphere to improve properties of CDW-based constituents via accelerated mineralization/carbonation, (ii) Development of holistically-designed advanced material property improvement technologies to even enhance the greenness of 100% CDW-based materials/structures through efficient CO2 binding/elimination capability, (iii) Validation of the ultimate products (materials/structures) with additional green perspective through a detailed large-scale field demonstration. Despite the abundance of studies in this area, there is currently very little work on demonstration activities on the real-time applicability of geopolymers development using industrial by-products and CDWs. Successful outputs of this study and their real-time demonstration will offer a fully sustainable construction system, including speed of construction/design flexibility/air purification/cost reduction/energy and material saving/avoidance of unwanted pollution-heavy demolition processes and make much larger audience to be influenced by the study’s results.
Potential Synergy Between Agile Management and the Mindset of Circular Economy in Construction Projects
Authors: Enembreck Flávia Luisa Pires , do Carmo Duarte Freitas Maria , Bragança Luís , Tavares Sergio Fernando 
Published: December 2023

AbstractThe focus of project management on processes and activities in the construction sector presents high variability and uncertainty. This article suggests the adoption of agile methodologies with an emphasis on people as an alternative that encourages reflection and anticipation of building maintenance and demolition problems. The objective is to identify the theoretical proximity between the main characteristics of agile construction project management and the circular economy mindset. The methodology used was a systematic bibliographical review and state-of-the-art content analysis on the application of agile in construction projects, with the discovery of the most cited characteristics and, subsequently, the establishment of a correlation with the elements of the circular economy mindset from inferences regarding the similarity of concepts and perspectives between both. From this analysis emerges the synergy between the circular and agile mindset. The conclusive trend is that architecture and construction benefit from the transitions from traditional management methodology to agile management and from the linear economy to the circular economy, given its limited technological stage in Brazil, in addition to the possibility of reducing waste generation and maintenance of the added value of buildings.
The Rehabilitation of Buildings from the Perspective of Circular Economy Principles
Authors: Freitas M. C. D. , Tavares S. F. , Bragança L. , Barbosa S. 
Published: December 2023

AbstractThe Material Bank (MB) of the city of Porto (Portugal) is an emblematic case that operates in the design phase of the rehabilitation of buildings from the perspective of the circular economy, acting as intermediation of information as a strategic resource in favor of the creation of a network of partners for the preservation of the old quarter with its historical and architectural heritage of the city. In this context, the study analyzes the actors, expectations and values with an emphasis on the circular economy and mitigation of construction and demolition waste. It consists of an exploratory-descriptive research, from qualitative nature, which uses bibliographical and documentary research to describe and analyze the Constructive Materials Bank of Porto City Council as a public policy capable of acting in the transition of the circular economy, noting that information is the key element in the mechanisms of reputation and trust, in the implementation of building rehabilitation projects and in the relationship between citizens and the city. The MB is an innovative model of public policy in managing and providing building materials of historical and architectural value. The idea is to align the heritage and cultural value of buildings with the principles of the circular economy.
Circular Economy Supporting Policies and Regulations: The Portuguese Case
Authors: Pedroso Marco Frazão , Tavares Vanessa 
Published: December 2023

AbstractConstruction is one of the critical sectors in the transition to a Circular Economy due to its contribution to resource depletion, waste, and emissions. Despite its acknowledged limitations (e.g., low productivity), the construction sector has been the focus of policies and regulations to improve its sustainability and circular economy capabilities. This study focuses on circular economy policies and regulations related to the construction sector in the European Union and Portugal, identifying political and regulatory barriers and opportunities. The analysis identified a growing number of publications since 2019 and divided the policies and regulations for the Circular Economy into four areas: Resource and Waste Management, Sustainable Development Goals, Green Public Procurement, and Circular Economy. Four main barriers were identified: policies and regulations harmonization, digital innovation (within the twin transition), support to the transition (e.g. financial and educational), and clear and focused governance models. It then discusses the documents and barriers, analyzes the Portuguese strategy (Portuguese Action Plan for Circularity in the Construction Sector), and proposes a strategy to be followed by other countries. The findings provide a holistic understanding of why policies and regulations fail to support Circular Economy day-to-day practices and provide insights on how to trigger the transition.
Analysis of Adaptability Requirements Against Their Implementation in Level(s) Framework
Authors: Askar Rand , Bragança Luís , Gervásio Helena 
Published: December 2023

AbstractThe adaptability of buildings is considered an essential criterion of sustainability and circularity of the built environment. Change is inevitable in our modern life. Therefore, designing buildings for adaptability and adaptive reuse is urgently necessary to save resources and prevent waste produced by arbitrary demolition activities. The circular economy recognises DfA “Design for Adaptability” as a key strategy to achieve the circularity of buildings, counting on the concept's ability to optimise the effectiveness of other strategies such as design for disassembly (DfD) and promote the waste hierarchy (reduce, reuse, recycle). The recognition is reflected in the EU framework for sustainability assessment Level(s), which embraces four circularity indicators in Macro Objective 2. The paper identifies adaptability requirements building on multiple adaptability and circularity assessment models. In light of these requirements, Level(s) consideration of DfA is examined, leading to multiple possible improvements to more inclusive and objective adaptability and circularity assessment.
Using City Information Modelling to Evaluate Urban Circularity Through Sustainability Indicators
Authors: Salles Adriana , Salati Maryam , Bragança Luís 
Published: December 2023

AbstractWhile promoting a holistic view of cities, sustainability assessment methods and the circular economy concept have gained attention among urban planners and policymakers. Those methods associated with information technologies can enable intelligent solutions to accelerate sustainability goals. City Information Modelling (CIM) can facilitate the assessment of urban sustainability and circularity. Continuing a previous study, this article examines whether traditional sustainability assessment tools may be adapted to CIM while promoting circular economy practices. Furthermore, the relationship between the most prioritized sustainability indicators and primary urban circularity concerns is examined through theoretical analysis. Therefore, a correlation matrix is proposed and indicators associated with each circularity concern are identified. In total, 24 indicators out of 48 are directly related to urban sustainability. Accordingly, this article discusses how urban circularity concerns can be determined using CIM, based on their correlation with the prioritized indicators. The findings indicate that a CIM-oriented strategy could be used to evaluate urban circularity concerns through sustainability indicators.
Supercritical CO2 drying of New Zealand red beech to below the fibre saturation point reduces collapse distortion
Authors: Pearson Hamish , Donaldson Lloyd , Kimberley Mark , Davy Bruce 
Published: December 2023

AbstractSupercritical CO2 offers an alternative method of removing wood moisture and reducing cellular collapse compared to traditional drying techniques. The technique has been previously demonstrated for Pinus radiata and Eucalyptus nitens dewatering and was modified in this study for New Zealand red beech (Nothofagus fusca) heartwood, which is notoriously difficult to dry without causing excessive distortion. The technique was also successfully extended to drying below the fibre saturation point. A specific dewatering and drying schedule was developed for N. fusca because of negligible dewatering using a schedule previously designed for wood with an open hydrofluidic network of interconnected vessels. An anatomical assessment confirmed lumen pathways were occluded with tyloses and polyphenol resins. A fluid dynamics assessment concluded that permeability measurements are recommended together with tortuosity and porosity information for improved wood species dewatering characterisation. Using the dewatering and drying schedule, collapse was successfully reduced by 92% for both normalised internal wood area and void collapse when compared to oven-dried samples. The beech specimens took 18 days to reach 17.3% moisture content (MC) but displayed some checking from early dewatering depressurisation, compared to air-dried control specimens which showed no collapse or checking but took 6 months to reach 12% MC. Supercritical CO2 dewatering and drying could be combined with extractives separation, preservative treatment, and mechanical forming of wood in one plant to make a potentially economically viable process with improved energy, environmental and carbon footprints. A techno-economic analysis is suggested to fully compare supercritical drying of wood against conventional drying operations.
High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response
Authors: Hahn Andreas , Reed Murray B. , Vraka Chrysoula , Godbersen Godber M. , Klug Sebastian , Komorowski Arkadiusz , Falb Pia , Nics Lukas , Traub-Weidinger Tatjana , Hacker Marcus , Lanzenberger Rupert 
Published: December 2023

Abstract
Purpose
Positron emission tomography (PET) provides precise molecular information on physiological processes, but its low temporal resolution is a major obstacle. Consequently, we characterized the metabolic response of the human brain to working memory performance using an optimized functional PET (fPET) framework at a temporal resolution of 3 s.

Methods
Thirty-five healthy volunteers underwent fPET with [18F]FDG bolus plus constant infusion, 19 of those at a hybrid PET/MRI scanner. During the scan, an n-back working memory paradigm was completed. fPET data were reconstructed to 3 s temporal resolution and processed with a novel sliding window filter to increase signal to noise ratio. BOLD fMRI signals were acquired at 2 s.

Results
Consistent with simulated kinetic modeling, we observed a constant increase in the [18F]FDG signal during task execution, followed by a rapid return to baseline after stimulation ceased. These task-specific changes were robustly observed in brain regions involved in working memory processing. The simultaneous acquisition of BOLD fMRI revealed that the temporal coupling between hemodynamic and metabolic signals in the primary motor cortex was related to individual behavioral performance during working memory. Furthermore, task-induced BOLD deactivations in the posteromedial default mode network were accompanied by distinct temporal patterns in glucose metabolism, which were dependent on the metabolic demands of the corresponding task-positive networks.

Conclusions
In sum, the proposed approach enables the advancement from parallel to truly synchronized investigation of metabolic and hemodynamic responses during cognitive processing. This allows to capture unique information in the temporal domain, which is not accessible to conventional PET imaging.
Reproductive success of Bornean orangutan males: scattered in time but clustered in space
Authors: van Noordwijk Maria A. , LaBarge Laura R. , Kunz Julia A. , Marzec Anna M. , Spillmann Brigitte , Ackermann Corinne , Rianti Puji , Vogel Erin R. , Atmoko S. Suci Utami , Kruetzen Michael , van Schaik Carel P. 
Published: December 2023

Abstract
The social and mating systems of orangutans, one of our closest relatives, remain poorly understood. Orangutans (Pongo spp.) are highly sexually dimorphic and females are philopatric and maintain individual, but overlapping home ranges, whereas males disperse, are non-territorial and wide-ranging, and show bimaturism, with many years between reaching sexual maturity and attaining full secondary sexual characteristics (including cheek pads (flanges) and emitting long calls). We report on 21 assigned paternities, among 35 flanged and 15 unflanged, genotyped male Bornean orangutans (Pongo pygmaeus wurmbii), studied from 2003 to 2018 in Tuanan (Central Kalimantan, Indonesia). All 10 infants born since mid-2003 with an already identified sire were sired by flanged males. All adult males ranged well beyond the study area (c. 1000 ha), and their dominance relations fluctuated even within short periods. However, 5 of the 10 identified sires had multiple offspring within the monitored area. Several sired over a period of c. 10 years, which overlapped with siring periods of other males. The long-calling behavior of sires indicated they were not consistently dominant over other males in the area around the time of known conceptions. Instead, when they were seen in the area, the known sires spent most of their time within the home ranges of the females whose offspring they sired. Overall, successful sires were older and more often resident than others.

Significance statement
It is difficult to assess reproductive success for individuals of long-lived species, especially for dispersing males, who cannot be monitored throughout their lives. Due to extremely long interbirth intervals, orangutans have highly male-skewed operational sex ratios and thus intensive male-male competition for every conception. Paternity analyses matched 21 immature Bornean orangutans with their most likely sire (only 10 of 50 genotyped males) in a natural population. Half of these identified sires had multiple offspring in the study area spread over periods of at least 10 years, despite frequently ranging outside this area. Dominance was a poor predictor of success, but, consistent with female mating tactics to reduce the risk of infanticide, known “sires” tended to have relatively high local presence, which seems to contribute to the males’ siring success. The results highlight the importance of large protected areas to enable a natural pattern of dispersal and ranging.
Prenatal dispositions and genetic analysis of monozygotic female twins with suprasellar cysts and hydrocephalus: A case report
Authors: Guldberg Frederikke , Larsen Carl Christian , Østergaard Elsebet , Carlsen Jonathan , Juhler Marianne , Munch Tina Nørgaard 
Published: December 2023

Abstract
Introduction
We present a unique case of monozygotic female twins with virtually identical clinical and radiological presentations of supratentorial hydrocephalus and cystic formations from the suprasellar cistern.

Discussion
Evaluating genetic predispositions and prenatal exposures is crucial for hydrocephalus in twins. Familial cases imply a genetic contribution to the development of these anomalies, including chromosomal abnormalities and specific variants linked to arachnoid cyst formation in various syndromes. Extensive genetic analyses found no pathogenic variants in the twins. Prenatal exposure to anti-epileptic medication was known during pregnancy and may be associated with fetal abnormalities, but not central nervous system (CNS) malformations, and was therefore not considered the cause of the condition in the twins. The twins presenting simultaneously with hydrocephalus caused by suprasellar cysts (SAC) underwent a two-step surgical management: initial ventriculoperitoneal shunt (VPS) placement followed by fenestration. Postoperative imaging showed cyst reduction, but a secondary VPS was necessary in both cases.

Conclusion
Genetic analysis is less likely to identify a monogenic etiology in non-syndromic cases of SACs, which are assumed to be multifactorial. There is no established evidence linking a teratogenic effect of anti-epileptic drugs to CNS malformations. Moreover, the surgical treatment of this complex condition constitutes a point of discussion.
DNA replication and replication stress response in the context of nuclear architecture
Authors: González-Acosta Daniel , Lopes Massimo 
Published: December 2023

AbstractThe DNA replication process needs to be coordinated with other DNA metabolism transactions and must eventually extend to the full genome, regardless of chromatin status, gene expression, secondary structures and DNA lesions. Completeness and accuracy of DNA replication are crucial to maintain genome integrity, limiting transformation in normal cells and offering targeting opportunities for proliferating cancer cells. DNA replication is thus tightly coordinated with chromatin dynamics and 3D genome architecture, and we are only beginning to understand the underlying molecular mechanisms. While much has recently been discovered on how DNA replication initiation is organised and modulated in different genomic regions and nuclear territories—the so-called “DNA replication program”—we know much less on how the elongation of ongoing replication forks and particularly the response to replication obstacles is affected by the local nuclear organisation. Also, it is still elusive how specific components of nuclear architecture participate in the replication stress response. Here, we review known mechanisms and factors orchestrating replication initiation, and replication fork progression upon stress, focusing on recent evidence linking genome organisation and nuclear architecture with the cellular responses to replication interference, and highlighting open questions and future challenges to explore this exciting new avenue of research.
A retrospective study of accuracy and usefulness of electrophysiological exercise tests
Authors: Periviita Vesa , Jokela Manu , Palmio Johanna , Udd Bjarne 
Published: December 2023

Abstract
Objectives
This study aimed to determine the usefulness of electrophysiological exercise tests. The significance of slightly abnormal exercise tests was also examined.

Methods
We identified all the patients who had undergone exercise testing between February 2007 to June 2022 in Tampere University Hospital, Finland. Their medical records after diagnostic workup and exercise test reports were reviewed. A binary logistic regression was performed to evaluate the association between positive test result in short exercise test, long exercise test, or short exercise test with cooling and genetically confirmed skeletal muscle channelopathy or myotonic disorder.

Results
We identified 256 patients. 27 patients were diagnosed with nondystrophic myotonia, periodic paralysis, myotonic dystrophy type 1, myotonic dystrophy type 2, or other specified myopathy. 14 patients were suspected to have a skeletal muscle channelopathy, but pathogenic variants could not be identified. The remaining 215 patients were diagnosed with other conditions than skeletal muscle channelopathy or myotonic disorder. The combined sensitivity of exercise tests was 59.3% and specificity 99.1%. Abnormal exercise test result was associated with increased risk of skeletal muscle channelopathy or myotonic disorder (OR 164.3, 95% CI 28.3–954.6, p < 0.001).

Conclusions
Electrophysiological exercise test is not optimal to exclude skeletal muscle channelopathy. It may be useful if a skeletal muscle channelopathy is suspected and genetic testing is negative or indeterminate and further evidence is required. Slightly abnormal exercise test results are possible in various conditions and result from different aetiologies. There is a demand for neurophysiological studies with higher sensitivity to detect skeletal muscle channelopathies.