bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological and immunohistochemical evidence of human papilloma virus (HPV) involvement in the dysplastic lesions of the uterine cervix
Authors: Syrjänen K. , Väyrynen M. , Castrén O. , Mäntyjärvi R. , Pyrhönen S. , Yliskoski M. 
Published: April 2004

AbstractA series of 110 biopsies of the uterine cervix containing dysplastic and/or in situ changes were assessed morphologiccally with reference to presence or absence of the coexistent condylomatous lesions, and using the immunoperoxidase‐PAP technique to disclose the HPV (human papilloma virus) antigens in the cells.Morphologically, 79 biopsies contained condylomatous (CO) lesions (63 flat, 12 inverted and 4 papillomatous ones), and 31 were non‐condylomatous (NCO) dysplasias/ in situ carcinomas. The mean age of the CO group was more than 10 years less than that of NCO women (P < 0.0001). Of the papillomatous COs, 75% were associated with mild or moderate dysplasia only, whereas 42% of the inverted ones contained an associated in situ carcinoma. Most of the flat lesions were found in very young women (10–39 years of age).HPV antigens were demonstrated in all papillomatous lesions (100%), in 83% of the inverted ones, and in 67% of the flat COs. In generally, the frequency of the HPV‐positive cases decreased when epithelial atypia increased. None of the NCO lesions showed HPV positive cells.The results support earlier morphological findings on the frequent association of cervical condylomas and epithelial dysplasias, as well as those on the HPV as the etiologic agent of the former. The role of HPV as a possible etiologic agent of the cervical squamous cell neoplasia deserves further attention.
Frozen section biopsy of ovarian neoplasms
Authors: Da Cunha Bastos Alvaro , Salvatore Carlos Alberto , Faria Roberto Mazza 
Published: April 2004

AbstractIn a study of the frozen section biopsy of 120 ovarian neoplasms, correct results were obtained in 94.16%, incorrect in 4.16%, and inconclusive in 1.66% of the 120 cases. The “incorrect” results were all “false‐negative.” No inverse “false‐positive” results were recorded, and the “incorrect” results occurred in cases of encapsulated neoplasms of a macroscopically benign appearance with small areas of malignant changes detected only by paraffin block technique. The authors conclude that frozen section biopsy of ovarian neoplasm is plausible so long as a pathologist is available who can be provided with the proper equipment during the surgery and that the technique is more indicated in patients up to the age of 40 because of the necessity of conservative management in this age group.
Human placental lactogen, pregnancy‐specific beta‐1‐glycoprotein and alpha‐fetoprotein in serum in threatened abortion
Authors: Hertz Jens B. , Schultz‐Larsen Peter 
Published: April 2004

AbstractThe predictive value of HPL, SP1 and AFP in serum were determined in 109 women admitted to hospital because of vaginal bleeding in the 6th to 19th gestational week. The prediction of abortion based on the initial analysis from the day of admission was found to be 91.7%, 75.9% and 81.8% for HPL, SP1 and AFP, respectively. The corresponding values for prediction of successful outcome were 68.7%, 73.6% and 65.4%. The HPL and AFP determinations were, however, found to be valid only after the 9th and 12th gestational week, respectively. A highly significant positive correlation (r = 0.84, P < 0.001) was demonstrated between HPL and SP1 suggesting that SP1 measurements might replace HPL in the evaluation of the prognosis in threatened abortion.
Carbon dioxide hysteroscopy immediately after second trimester abortion
Authors: Van Lith D.A.F. , Beekhuizen W. , Van Schie K.J. , Van Der Pas H. , Lindemann H.J. 
Published: April 2004

AbstractThe use of hysteroscopy has been restricted a.o. by the need for general anesthesia. This applies in particular to the pre‐ or postpartum period, because the hyperemic atonic uterus is easily over‐inflated to a dangerous level. Over‐inflation did not occur following 50 aspirotomy D & E procedures in the second trimester, using a para‐ and intracervical block with lidocaine 1% with adrenaline 1:200,000 only. The uterine cavity was always thoroughly evacuated in these cases in which final check suction had been performed. We recommend that postabortum hysteroscopy should be performed preferably under local anesthesia.
Cephalopelvic disproportion at term involving a lithopedion: A case report
Authors: Leke R.J.I. , Nasah B.T. , Shasha W. , Monkam G. 
Published: April 2004

AbstractA case of obstructed labor in a term pregnancy caused by cephalopelvic disproportion as a result of a lithopedion retained in a sacculus of the lower uterine segment is reported. Detection and management of this condition are discussed, and a review of relevant literature is also presented.
Dysmenorrhea in women with intrauterine contraceptive device. Treatment with a prostaglandin synthetase inhibitor, naproxen
Authors: Lalos Othon , Nilsson Berit 
Published: April 2004

AbstractTwenty‐one women with intrauterine contraceptive devices (IUCD) and severe dysmenorrhea were studied. All the women who participated in the study had primary dysmenorrhea of varying intensities. The insertion of IUCD increased the intensity of dysmenorrheic pain. The effect of naproxen (Naprosyn®) on pain alleviation was studied in a double‐blind cross‐over trial using naproxen and placebo. The effect of naproxen was significantly better than that of placebo (P < 0.01). No severe side effects occurred during the treatment. There was no difference in the duration and amount of the menstrual blood flow during naproxen treatment compared to placebo according to the women's own judgement.
Intrapartum rupture of uterus diagnosed by ultrasound: A case report
Authors: Suonio S. , Saarikoski S. , Kääriäinen J. , Virtanen R. 
Published: April 2004

AbstractA case of ruptured uterine scar of a previous cesarean section diagnosed by ultrasound is presented. Because of the severity of the complication and the great variation of symptoms in connection with it, the authors encourage the use of ultrasound screening in the detection of this rare, but often catastrophic complication.
The treatment of rupture of the pregnant uterus. Analysis of 93 cases treated in a rural hospital in Zambia
Authors: Heij H.A. , Te Velde E.R. , Cairns J.M. 
Published: April 2004

AbstractIn this study 93 cases of uterine rupture, treated in a rural hospital in Zambia have been analyzed. Clinical characteristics and mortality rate were found to be comparable to those reported in other series from developing countries. An attempt was made to compare the outcome of various surgical procedures. No statistically significant differences were found between the mortality rates after repair, subtotal and total hysterectomy (12%, 13% and 28%, respectively). A survey of recent literature on the treatment of uterine rupture in developing countries revealed a wide divergence of opinions and criteria of selection, precluding reliable comparisons. A proposition for individualized treatment is outlined, concluding that repair should be performed when suitable but that hysterectomy is preferable when the tear is extensive, bruised and contaminated.
Low serum selenium concentration in patients with cervical or endometrial cancer
Authors: Sundström Helena , Yrjänheikki Erkki , Kauppila Antti 
Published: April 2004

AbstractSerum concentrations of selenium were determined in 37 patients with cervical and 64 patients with endometrial cancer. The patients had lower (P < 0.001) serum concentrations of selenium than the age‐, weight‐ and place of residence‐matched paired control women. There was no difference in the selenium concentration between various age groups or different clinical stages of cervical or endometrial cancer. A low serum concentration of selenium might be a contributing factor in uterine carcinogenesis.
Quantitation of immunoglobulin A in the human chorioamniotic membrane
Authors: Berezowski A.T. , Cunha S.P. , Costa J.C. , Santos R.R. , Duarte G. 
Published: April 2004

AbstractThirty‐eight chorioamniotic membranes were obtained from normal patients divided into three groups according to time of rupture. A protein extract was obtained by destruction and differential centrifugation and immunoglobulin A was measured by the method of Mancini. The authors demonstrated that it is possible to quantitate immunoglobulin A. No statistically significant differences were observed between groups.
The value of laparoscopy in women with chronic pelvic pain and a “normal pelvis”
Authors: Levitan Zohar , Eibschitz Izu , de Vries Karl , Hakim Marwan , Sharf Mordechai 
Published: April 2004

AbstractDuring the period January 1976–December 1982 laparoscopy was performed on 186 women complaining of pelvic pain of at least 6 months' duration. In all these cases, the routine pelvic examination and other medical and laboratory tests were negative. Laparoscopy revealed pelvic pathology in only 8.2%: in the vast majority (91.8%) entirely normal pelvic organs were seen. Evidence from the literature is compiling as to the psychogenic origin of most cases of chronic pelvic pain. Recently, it has been shown that laparoscopically negative pelvic pain can be relieved or abolished by psychological intervention. Since pathological findings on laparoscopy are of very low percentage and since the pain is psychogenic in most cases, the value of routine laparoscopy in chronic pelvic pain is very low. We propose that all women with chronic pelvic pain and normal pelvic examination should undergo psychological assessment and treatment if necessary. Laparoscopy should then be reserved for only those cases who show no amelioration on psychological intervention. Our estimation is that this approach would reduce the rate of laparoscopies performed for chronic pelvic pain by about 90%.
The use of bromocriptine in hyperprolactinemia and galactorrhea in Singapore
Authors: Tsakok F.H.M. , Yong Y.M. , Ng C.S.A. 
Published: April 2004

AbstractNinety‐four women and seven men were treated with low dose bromocriptine for (a) hyperprolactinemia or (b) normoprolactinemia but with galactorrhea and a pituitary adenoma. All the pituitary adenomas became smaller or remained the same. Prolactin levels decreased with treatment and inappropriate galactorrhea improved in the 53 patients except for 7 where there was no change. Of the 41 women with premenstrual mastalgia 78% improved with treatment. Of the 74 women with ovulatory problems, a biphasic pattern was restored in 65 patients. Thirty‐two patients out of the 92 trying to conceive achieved a pregnancy with an abortion rate of 12.5% and non‐lethal congenital abnormality of 9.8% (2.1% in Singapore population). Fertility was restored in 3 hyperprolactinemic oligospermic males and improved libido was professed by most of the treated men. Side effects were present but were on the whole tolerable.Pregnancy rate was better in those with high levels of prolactin (>1000 miU/l) than in those with hyperprolactinemia of between 500 and 1000 miU/l although this was not statistically significant χ2 = 0.69. In the lower hyperprolactinemic range there was noticeable number of patients with endometriosis and increased luteinizing hormone (LH) levels.
Raised uterine resting tone in patients with abruptio placentae
Authors: Odendaal H.J. , Burchell H. 
Published: April 2004

AbstractUterine contractions were studied in 21 patients with abruptio placentae and intrauterine death. Contractions were examined in four 10‐minute windows taken immediately prior to delivery, 30 and 60 minutes before delivery and at the beginning of the recording. Mean resting tone values for the 4 periods fluctuated between 23 and 25 mmHg. The mean contraction frequency for all the windows was 8 per 10 minutes. It is postulated that the high resting tone and frequent uterine contractions contribute to the high perinatal mortality associated with abruptio placentae.
The physiological effect of infant mortality in reproductive behavior in the Sudan
Authors: Nur Osman El‐Hassan M. 
Published: April 2004

AbstractThe present study examines the physiological effect of infant mortality on reproductive behavior for the Sudan using retrospective pregnancy history data for ever‐married women, 15–49. The investigation has revealed that the death of an infant reduces the subsequent birth interval significantly, by about 6 months. This difference in the length of birth interval appears to be primarily a result of the interruption of lactation. When the birth intervals are examined by the fate of the two preceding children, the analysis shows insufficient evidence to indicate that infant mortality affects the length of birth intervals independently of the physiological effect.
Socioeconomic and demographic characteristics of induced abortion cases
Authors: Chatterjee T.K. 
Published: April 2004

AbstractThe age, parity, marital and socioeconomic status, education, religion, profession and the period of gestation of 200 patients who applied for legal abortions are analyzed.In this study 74% of the women were more than 20 years of age, 75% had attended secondary school, 63% were students or clerks, 53% came from lower‐ or middle‐class families, 40% were Roman Catholics, 45% were unmarried, 40% were nulliparous and 57% had little or no knowledge of contraception.
Post‐operative chemotherapy for ovarian carcinoma: A prospective study with cyclophosphamide
Authors: Akinkugbe A. , Uguru V.E. , Mordi V.P.N. 
Published: April 2004

AbstractSeventy consecutive patients with carcinoma of the ovary were managed in our unit by laparotomy and extensive debulking procedures over a period of 8 years. Intensive post‐operative chemotherapy was given with intravenous cyclophosphamide. The mean follow‐up period was 2.6 years. Our results showed that 19 patients with early disease (stages I and II) showed complete remission but seven subsequently died of recurrent disease. The others with more advanced disease showed little response to treatment.
Disseminated pelvic hydatidosis presenting as ovarian carcinomatosis: Successful post‐operative treatment with mebendazole
Authors: Mousa A.M. , Mehrez M.G. , Muhtaseb S.A. , Al‐Mudalal D.S. , Kamel S.M. 
Published: April 2004

AbstractThe case of a female with disseminated pelvic cystic hydatidosis presenting as ovarian carcinomatosis 2.5 years after repeated abdominal paracentesis is reported. The diagnosis was made during surgery and confirmed by serology and histological examination. Over 100 cysts were removed from the abdominal cavity and wall. Innumerable small cysts studded the viscera; these and larger inaccessible ones were untouched. Medical cure in this patient was achieved with a combination of partial resection and special irrigation, broad spectrum antibiotic for coverage of infectious episodes and high dose long term mebendazole therapy for 25 months. The danger of blind aspiration in patients coming from endemic areas is emphasized.
Colposcopic findings of gland openings in cervical carcinoma: Their histological backgrounds
Authors: Kishi Y. , Inui S. , Sakamoto Y. 
Published: April 2004

AbstractDuring the past 8 years 1501 colposcopies were performed paying a special attention to cervical glands for diagnosis of cervical intra‐epithelial neoplasia (CIN) and carcinoma. Normal openings could exclude these diseases at the error rate of only 5.1%, while atypical openings could identify them at the high confidence rate of 96.3%. False positive evaluations were mostly attributable to a marked degree of squamous metaplasia in the glands. The absence of gland openings in the main portion of the lesions amounted to 88.6% in invasive carcinomas but to only 12.4% in CIN. Adenoma malignum was a highly characteristic exception.
A lifetable analysis of sterilization failure: Data from the profamilia clinic, Bogota, Colombia
Authors: Trias M.F. , Anderson J.E. , Ojeda G. , Oberle M.W. 
Published: April 2004

AbstractSterilization failure rates were computed using lifetable methods for sterilizations occurring between 1973 and 1982 in the Profamilia family planning clinic in Bogota, Colombia. Out of a total of nearly 45,000 sterilizations occurring during this period 503 sterilization failures were detected. Comparing methods, laparoscopy with the silastic band method had a significantly higher rate of failure, 1.5% after 5 years compared to 0.9% for laparoscopy with cautery and 0.6% for minilaparotomy.
Nausea and vomiting in early pregnancy
Authors: Vellacott I.D. , Cooke E.J.A. , James C.E. 
Published: April 2004

AbstractTo study the problem of nausea and vomiting in early pregnancy an epidemiological survey was undertaken, obtaining information from 500 consecutive antenatal patients. Seventy‐six percent of women complained of symptoms during the first trimester, and in only 27% had the symptoms resolved by the twelfth week. Job efficiency was markedly impaired. Women who suffered nausea premenstrually, or on the oral contraceptive pill, were much more likely to develop symptoms, lending credence to a hormonal etiology for the condition.
Menarcheal age in Ghanaian school girls
Authors: Adadevoh S.W.K. , Agble T.K. , Hobbs C. , Elkins T.E. 
Published: April 2004

AbstractIn a cross‐sectional retrospective study of 2087 Ghanaian school girls in various educational institutions in the Kumasi district, Ashanti region, Ghana, the mean menarcheal age was found to be 13.98 ± 1.42 years. Differences in the menarcheal age of the girls was found to be significantly correlated to social class, parents ethnic origin, educational institution and home living area (P = 0.0001). The duration of the menarche and the interval between the menarche and the second period was found to be influenced by the age at menarche (P < 0.01). Decline in menarcheal age in concurrence with world trends was observed. Further studies are necessary to identify the inherent and specific factors in the Ghanaian population which relate to and influence the age of menarche.
Maternal mortality inquiry in a rural community of North India
Authors: Kumar R. , Sharma A.K. , Barik S. , Kumar V. 
Published: April 2004

AbstractCommunity inquiry on maternal mortality was conducted in a rural area of North India. Maternal deaths were identified by multiple informants and investigated by doctors. Amongst 257 deaths registered in women in the 15–44 year age group, 55(21.4%) were maternal deaths. Maternal mortality ratio was 230 per 100,000 live births. Major causes were antepartum and postpartum hemorrhage (18.2%), puerperal sepsis (16.4%), severe anemia (16.4%), abortion (9.1%) and obstructed labor (7.3%). This rapid, simple and low cost method is recommended for application in areas where vital registration system is unsatisfactory.
Initiation of labor with a moderately favorable cervix: a comparison between prostaglandin E2 gel and oxytocin
Authors: Rayburn W. , Woods R. , Eggert J. , Ramadei C. 
Published: April 2004

AbstractThis study compares prostaglandin E2 (PGE2) gel and oxytocin for the initiation of labor in term pregnancies with a moderately favorable cervix (Bishop score 5–8). Compared with a matched group, 48 cases treated with PGE2 gel (2.5 mg intravaginally) required significantly less or no oxytocin, had shorter first stages of active labor, and had no increased risk of uterine hyperstimulation or cesarean section. Initiation of labor with low dose PGE2 when the cervix is moderately favorable is less labor intensive and meets with more patient satisfaction.
Hysterosalpingography versus laparoscopy in tubal infertility: comparison based on findings at laparatomy
Authors: Okonofua F.E. , Essen U.I. , Nimalaraj T. 
Published: April 2004

AbstractOne hundred ten infertile women underwent hysterography (HSG) and laparoscopy at the Obafemi Awolowo University, Nigeria. Both techniques showed normal tubal potency in 62 (56.4%) women and abnormal pelvic pathology in 48 (43.6%). All 48 women underwent laparotomy for tuboplasty. At laparotomy, HSG and laparoscopic assessments were compared. Both techniques were comparable in the diagnosis of intratubal and distal tubal occlusion. However, laparoscopy was superior in the diagnosis of non‐tubal factors and proximal tubal occlusion (P < 0.002). It is suggested that laparoscopy should be the first procedure in the investigation of tubal infertility and only followed by HSG if the results show some abnormality.
Factors relating to the volume of surgical knots
Authors: Trimbos J.B. , Brohim R. , van Rijssel E.J.C. 
Published: April 2004

AbstractThe suture's knot site represents the highest amount and density of foreign body material of a knotted suture loop. The volume of a knot is directly related to the total amount of inflammatory reaction surrounding the knot. We measured the volume of seven surgical knots frequently used in surgical practice. Two different suture materials and two different sizes were tested. Suture size was found to contribute significantly more to the volume of all knots tested than the number of throws of which the knots were composed. Knots made with coated multifilament polyglactin‐910 were significantly larger than the knots made with monofilament nylon. Clinical implications of these findings are discussed. Surgical techniques keeping the volume of knots to a possible minimum, are encouraged.
A comparative study of the estrogen receptor ratio in myometrium and uterine leiomyomas
Authors: Otsuka H. , Shinohara M. , Kashimura M. , Yoshida K. , Okamura Y. 
Published: April 2004

AbstractEstrogen receptor (ER) content in myoma and myometrium was determined by radio‐receptor assay (RRA), and ER staining was performed by immunocytochemical staining, i.e. the peroxidase‐antiperoxidase (PAP) method, in uterine samples from eight patients with uterine leiomyoma. ER content in myoma tended to be hither than that in myometrium, but the difference was not significant. The distribution pattern of ER staining was thought to be an important criterion. When the data were compared on the basis of the number of cells in the site where the largest number of positive cells aggregated, the number for myoma was significantly higher than that for myometrium (P < 0.05). These results suggest that myoma contains more ER positive cells to obtain estrogen effects than myometrium.
Carcinoma of the cervix in the African setting
Authors: Rogo K.O. , Omany J. , Onyango J.N. , Ojwang S.B. , Stendahl U. 
Published: April 2004

AbstractCarcinoma of the cervix is the commonest female malignancy in sub‐Saharan Africa today. A brief description of its prevalence and distribution is given. Kenyan data is then used to illustrate the predominance of advanced disease in mostly premenopausal women (70%) of high parity. Follow up is characteristically poor and treatment results, although difficult to calculate with accuracy, are also poor. These are compared to FIGO statistics. Against this background aspects peculiar to the tumor, patient and treatment facilities in Africa are cited and discussed with reference to current relevant literature.
Recurrent pulmonary embolism in pregnancy managed with the Greenfield vena caval filter
Authors: Banfield P.J. , Pittam M. , Marwood R. 
Published: April 2004

AbstractRecurrent embolisation from venous thrombosis despite anticoagulation, in pregnancy, constitutes a major diagnostic and management problem. We present just such a patient who was managed with a Greenfield vena caval filter, which enabled her pregnancy to continue, resulting in a vaginal delivery of a healthy female infant at 38 weeks gestation.