bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA Double-Strand Break Movement in Heterochromatin Depends on the Histone Acetyltransferase dGcn5
Authors: Kendek Apfrida , Sandron Arianna , Lambooij Jan-Paul , Colmenares Serafin U. , Pociunaite Severina M. , Gooijers Iris , de Groot Lars , Karpen Gary H. , Janssen Aniek 
Published: November 2023

AbstractCells employ diverse strategies to repair double-strand breaks (DSBs), a dangerous form of DNA damage that threatens genome integrity. Eukaryotic nuclei consist of different chromatin environments, each displaying distinct molecular and biophysical properties that can significantly influence the DSB repair process. Specifically, DSBs arising in the compact and silenced heterochromatin domains have been found to move to the heterochromatin periphery in mouse andDrosophilato prevent aberrant recombination events. However, it is poorly understood how chromatin components, such as histone post-translational modifications, contribute to these DSB movements within heterochromatin. Using locus-specific DSB induction inDrosophilatissues and cultured cells, we identify that histone H3 lysine 9 acetylation (H3K9ac) is enriched at DSBs in heterochromatin but not euchromatin. We find that this enrichment is mediated by the histone acetyltransferase dGcn5, which rapidly localizes to heterochromatic DSBs. Moreover, we demonstrate that in the absence of dGcn5, heterochromatic DSBs display impaired recruitment of the SUMO E3 ligase Nse2/Qjt and fail to relocate to the heterochromatin periphery to complete repair. In summary, our results reveal a previously unidentified role for dGcn5 and H3K9ac in heterochromatin DSB repair and underscore the importance of differential chromatin responses at heterochromatic and euchromatic DSBs to promote safe repair.
What's in a name? That we call fair by any other name will it sell as well?
Authors: Bakshi Abhinav , Vijayalakshmi Akshaya 
Published: November 2023

Emami is facing the heat from activist-consumers as well as its competitors. Competitors have renamed their cosmetic products by dropping the controversial word ‘fair.’ This was in response to the Black Lives Movement that erupted in the United States in May 2020. However, the movement against fairness is somewhat muted in India and is mostly occurring amongst urban, highly educated, younger cohort who are unlikely to be the users of the product anyway. The significant consumer base yearns for fairness and is willing to spend money on products which help them achieve the same. In such a scenario, how should Emami respond to competitor actions and consumer-activist pressure?
The case provides an opportunity to discuss the significance of the brand name, role of advertising and gender stereotypes.
Eruvaka: time to step up in entrepreneurial life cycle
Authors: Salwan Prashant , Pandey Shailesh , Raviteja M.S. 
Published: November 2023

Learning outcomes
On completion of this case study, students will be able assess new venture opportunities by properly allocating expansion fund in growing the business; analyzing various scaling-up options; applying the Ansoff matrix for growth and expansion; designing a framework for scaling up; and using the business model canvas.

Case overview/synopsis
Mr Sreeram established Eruvaka Technologies in Vijayawada, Andhra Pradesh (India), in 2015 to provide products and services related to aquaculture. The company was founded with the goal of assisting prawn farmers who had trouble keeping up with the demands of the industry. Eruvaka Technologies created risk-reducing and productivity-boosting on-farm diagnostic devices for aquaculture growers. The company developed low-cost monitoring and automation solutions for aquaculture by merging sensors, mobile connection and decision tools. Eruvaka’s primary objective was to offer reasonably priced, technologically advanced goods and services to farmers. Eruvaka matured into a promising startup over time, attracting $5m in funding. Sreeram and his team had to detail their plan to their investors about how they intended to use the money from each funding rounds toward growing the business, how the company planned to achieve sustainable and competitive advantage while providing value to its consumers and how they would address critical issues including product acquisition cost, supply chain problem and customer anxiety.

Complexity academic level
This case study can be taught as part of undergraduate- and postgraduate-level courses and Master of Business Administration courses.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
Assessing the countries’ convergence to IPSAS from a cultural perspective
Authors: Gomes dos Santos Paula , Albuquerque Fábio 
Published: November 2023

Purpose
This paper aims to assess the factors that may explain the International Public Sector Accounting Standards (IPSAS) convergence, considering Hofstede’s cultural dimensions as the theoretical reference for the cultural approach proposed. Additional factors include countries’ contextual and macroeconomic characteristics.

Design/methodology/approach
Logistic and probit regression models were used to identify the factors that may explain the IPSAS (fully or adapted) use by countries, including 166 countries in this assessment (59 for those whose cultural dimensions are available).

Findings
The findings consistently indicate collectivism and indebtedness levels as explanatory factors, providing insights into cultural dimensions along with macroeconomic characteristics as a relevant factor of countries’ convergence to IPSAS.

Research limitations/implications
There are different levels of IPSAS convergence by countries that were not considered. This aspect may hide different countries’ characteristics that may explain those options, which could not be distinguished in this paper.

Practical implications
As a result of this paper, the International Public Sector Accounting Standards Board may gain insights that can be applied within the IPSAS due process to overcome the main challenges when collaborating with national authorities to achieve a high level of convergence. This analysis may include how to accommodate countries’ cultural differences as well as their contextual and macroeconomic characteristics.

Social implications
There is a trend of moving toward accrual-based accounting standards by countries. Because the public sector embraces a new culture following the IPSAS path, it is relevant to assess if there are cultural factors, besides contextual and macroeconomic characteristics, that may explain the countries’ convergence to those standards.

Originality/value
To the best of the authors’ knowledge, this is the first cross-country analysis on the likely influence of cultural dimensions on IPSAS convergence as far as the authors’ knowledge.
A bibliometric review of consumers’ purchase behaviour for solar energy products
Authors: Fathima M.S. Arshiya , Khan Adil , Alam Ansari Sarwar 
Published: November 2023

Purpose
This study aims to conduct the domain mapping of consumer behaviour research in the context of solar energy. The study can help in understanding the intellectual structure, evolution of keywords and key research producers (at the author, institutional and source level) related to the domain of solar energy consumer research.

Design/methodology/approach
This study uses R-studios’ bibliometrix package for analysing the bibliographical data collected from the Scopus database. Analysis has been conducted at the descriptive level (summary, author, institution and source) and analytical level (co-citation analysis, co-occurrence analysis, thematic maps and historiography).

Findings
This study finds out the most relevant authors, institutions and sources using criteria such as production, citations and H-index. Relevant research clusters have been identified using the clustering of authors, co-citations and keywords. Thematic mapping has identified the basic and motor themes. Historical citation analysis shows the direct linkage of previous studies. Overall, this study reports the most relevant bibliometric indicators in the domain of solar energy consumer research.

Practical implications
Identified patterns can help policymakers, business experts, social marketers and energy conservation organisations to study consumer behaviour.

Social implications
Thiis bibliometric study can effectively assess sustainable development goals and suggest improved action plans.

Originality/value
This study examined bibliometric analysis in solar energy products (SEPs), recognised varied domains of research work on consumers’ intention to purchase solar household products and mapped them into six groups. This study provides an overview of 40 years of research on consumer behaviour towards SEPs and discusses its findings to identify the research gap.
Am I being abandoned? The value of retirement homes in Malaysian society
Authors: Low Sheau-Ting , Neo Li-Ting , Choong Weng-Wai , Mansor Razlin , Wee Siaw-Chui , Woon Jing-Ying 
Published: November 2023

Purpose
The world population over the age of 60 is expected to increase from 900 million in 2015 to two billion by 2050. Retirement homes have emerged as a prominent housing alternative and become a trend for the older adults; however, older population in Malaysia could have a negative view of retirement homes. Different generations could have different perceptions of the value of retirement homes. This study aims to explore the value of retirement homes across diverse age cohorts in Malaysia.

Design/methodology/approach
A qualitative approach is adopted for this study. Thematic analysis is used to analyse the interview transcripts obtained from semi-structured interviews.

Findings
The results indicated that baby boomers tend to have more negative values towards retirement homes, whereas Generations X and Y demonstrated more favourable and positive values for retirement homes.

Originality/value
This study serves as a useful reference for housing developers, policymakers and the management of retirement homes to better understand how different age cohorts value retirement homes, thereby encouraging relevant housing strategies to enhance the quality and support systems of retirement homes in society.
Analysis on the effects of global supply chain reconfiguration on China's high-end equipment manufacturing industry
Authors: Zhang Xufan , Fan Xue , He Mingke 
Published: November 2023

PurposeThe challenges faced by China's high-end equipment manufacturing (HEEM) industry are becoming clearer in the process of global supply chain (GSC) reconfiguration. The purpose of this study is to investigate how China's HEEM industry has been affected by the GSC reconfiguration, as well as its short- and long-term strategies.Design/methodology/approachThe authors adopted a multi-method approach. Interviews were conducted in Phase 1, while a three-round Delphi survey was conducted in Phase 2 to reach consensus at the industry level.FindingsThe GSC reconfiguration affected China's HEEM supply chain (SC). Its direct effects include longer lead times, higher purchasing prices and inconsistent supply and inventory levels of key imported components and materials. Its indirect effects include inconsistent product quality and cash flows. In the short term, China's HEEM enterprises have sought to employ localized substitutes, while long-term strategies include continuous technological innovation, industry upgrades and developing SC resilience.Originality/valueThis study not only encourages Chinese HEEM enterprises to undertake a comprehensive examination of their respective industries but also provides practical insights for SC scholars, policymakers and international stakeholders interested in how China's HEEM industry adapts to the GSC reconfiguration and gains global market share.
Children's voices through play-based practice: listening, intensities and critique
Authors: Burke Lynsey Anne , Mercieca Duncan 
Published: November 2023

PurposeThis paper offers a reflection of a research process aimed at listening to young children's voices in their everyday school life through a play-based context in a Scottish school. Throughout the research process, the complexity of conducting this research was kept in mind as listening to children's voices presents methodological and conceptual difficulties and tensions. Reflecting on the research process after the data was collected, the process was critiqued using Deleuze-Guattarian ideas. The critique aims at opening and challenging each researcher, allowing them to think-again about the next research project aimed at listening to children's voices.Design/methodology/approachThe research involved an observation study that took place over one week in a primary school in Central Scotland. As part of the educators' approach to play-based pedagogy, children had the opportunity to engage in free play throughout the day. Observations were chosen as the main approach to “capture” children's voices in their natural settings.FindingsThe empirical research brought forth two main ideas, that of children as agents, and how children amplify their voices through play. The reflective part offers the possibility of understanding the intensities and forces when conducting such research and the possibilities of engaging with these.Originality/valueThis paper offers a critique of research aimed at listening to children's voices. The aim is not to limit engagement in researching children's voices but to open, or make complex, such processes.
Regional Employment Impacts of Biorefineries in the EU
Authors: Zhu Benz Xinqi , Vrachioli Maria , Sauer Johannes 
Published: November 2023

SummaryThe European Commission aims to achieve a climate‐neutral economy by 2050 and positively affect the employment growth rate while reducing fossil‐based production activities. For that reason, according to the European Green Deal, decarbonisation and modernisation of fossil‐based industries is essential. Thus, replacing fossil fuel‐based inputs in these industries with bio‐based inputs through the establishment of biorefineries can contribute towards this goal. This article reports the results of a study on the impact of biorefineries on the regional employment rate, and other regional socio‐economic indicators. A unique regional level dataset provided by EU Joint Research Centre and the EU H2020 BioMonitor project is used to examine the impact of the biorefinery industry on local employment. This dataset covers multiple European Member States and enables us to account for regional characteristics over a 10‐year period (2009–2018). Our results show that introducing biorefineries to a region can be associated with a higher regional employment growth compared to regions with no biorefineries. Improving biorefinery data availability and quality can assist further the research in this area and promote the development of bioeconomy in Europe.
Exploring herbal remedy utilization for wound healing: Patterns, patient preferences, and implications for nursing practice
Authors: Setyawati Andina , Yusuf Saldy , Jafar Nuurhidayat , Sagita Rina Wijayanti 
Published: November 2023

AbstractPurposeThe utilization of herbal remedies for wound healing is a notable aspect of traditional medicine practices. Understanding herbal use among patients yields insights for nursing care enhancement. This study aimed to investigate the utilization of herbal remedies for wound healing among diabetic patients.MethodsA total of 453 participants were enrolled, with demographic data, including age, sex, occupation, education level, residence, ethnic group, distance from health service, herbal use duration, and wound duration presented. Descriptive statistics were used to analyze the data, including means, standard deviations, ranges, and percentages.FindingsThe average participant age was 55.39 years, with most being non‐civil servant workers (60.3%) and having a low education level (67.1%). Indian almond wood (9.7%) and green betel (6.8%) were the most commonly used herbs for wound healing. Family members were the primary source of information (29.1%), and 43.7% obtained herbs from personal gardens. Although 94.2% of participants did not disclose herbal use to health liaisons, 53.4% used herbs specifically for wound healing. Users reported both positive and negative effects on wounds from various herbs, indicating variability in experiences. However, the consistency of herb usage by individual patients was uncertain.ConclusionsThe study identified diverse herbal remedies used for wound healing among patients, driven by familial recommendations. Usage pattern diversity and effects signal necessity for researching herb safety and efficacy. Clarifying the impact of consistent herb usage on wound healing is essential for understanding patients’ preferences and practices.Implications for clinical practiceThese findings emphasize the importance of open communication between patients and healthcare providers regarding herbal remedy use. Nurses should acknowledge patients’ preferences for traditional healing practices while ensuring they receive evidence‐based care. Patient‐centered herbal strategies enhance nursing practice, fostering holistic wound care. Further research can guide nursing interventions, facilitate informed decision‐making, and improve patient outcomes.
Evaluation of the potential drug–drug interactions of carotegrast methyl with midazolam, prednisolone or atorvastatin in healthy adults
Authors: Matsuki Shunji , Oikawa Ichiro , Koyama Tetsuya , Imai Hiromitsu 
Published: November 2023

AimsThis study evaluated drug–drug interactions between the CYP3A4 inhibitor carotegrast methyl and the other CYP3A4 substrates, midazolam, atorvastatin and prednisolone.MethodsA total of 88 healthy volunteers orally received carotegrast methyl 960 mg 3 times daily for 14 days. A single oral (5 mg) or intravenous (0.017 mg kg−1) midazolam, oral (5 mg) prednisolone or oral (10 mg) atorvastatin was administered before, with and after carotegrast methyl treatment. When the 90% confidence interval (CI) for the geometric mean ratios of the pharmacokinetic (PK) parameters with coadministration with carotegrast methyl (Day 14) to those before carotegrast methyl administration was between 0.80 and 1.25, no PK interaction were deemed.ResultsThe Cmax and AUC0‐t of oral midazolam before administration of carotegrast methyl were 30.9 ± 9.8 ng mL−1 and 74.5 ± 21.9 ng h mL−1, respectively. The geometric mean ratio of the Cmax and AUC0‐t of midazolam on Day 14 to those on Day −1 was 1.86 (90% CI, 1.64–2.11) and 3.07 (90% CI, 2.81–3.35), which did not fall within the range of 0.80–1.25, suggesting that carotegrast methyl had a PK interaction with midazolam. Similar PK interactions were found for intravenous midazolam and atorvastatin, but not for prednisolone. The inhibitory effect of carotegrast methyl on CYP3A4‐mediated metabolism of midazolam and atorvastatin had almost disappeared by 14 days after the end of administration.ConclusionCarotegrast methyl was classified as a moderate CYP3A4 inhibitor in humans. Carotegrast methyl might enhance the action of drugs that are metabolized by CYP3A4.
DDX5 enhances HIF‐1 activity by promoting the interaction of HIF‐1α with HIF‐1β and recruiting the resulting heterodimer to its target gene loci
Authors: Shirai Yukari , Suwa Tatsuya , Kobayashi Minoru , Koyasu Sho , Harada Hiroshi 
Published: November 2023

AbstractBackground InformationCancer cells acquire malignant characteristics and therapy resistance by employing the hypoxia‐inducible factor 1 (HIF‐1)‐dependent adaptive response to hypoxic microenvironment in solid tumors. Since the underlying molecular mechanisms remain unclear, difficulties are associated with establishing effective therapeutic strategies.ResultsWe herein identified DEAD‐box helicase 5 (DDX5) as a novel activator of HIF‐1 and found that it enhanced the heterodimer formation of HIF‐1α and HIF‐1β and facilitated the recruitment of the resulting HIF‐1 to its recognition sequence, hypoxia‐response element (HRE), leading to the expression of a subset of cancer‐related genes under hypoxia.ConclusionsThis study reveals that the regulation of HIF‐1 recruitment to HRE is an important regulatory step in the control of HIF‐1 activity.SignificanceThe present study provides novel insights for the development of strategies to inhibit the HIF‐1‐dependent expression of cancer‐related genes.
Combination of fenchone and sodium hyaluronate ameliorated constipation‐predominant irritable bowel syndrome and underlying mechanisms
Authors: Cui Li , Hua Yongzhi , Zou Shuting , Gu Chao , Li Hui 
Published: November 2023

AbstractWe sought to explore the protective effect of the combination of fenchone (FE) and sodium hyaluronate (SH) on ice water‐induced IBS‐C rats and the potential mechanism. The neurotransmitter levels, including substance P (SP), motilin (MTL), 5‐hydroxytryptamine (5‐HT), and vasoactive intestinal peptide (VIP), were determined by ELISA methods. The stem cell factors (SCF)/c‐Kit signaling pathway‐related protein and mRNA levels were determined by western blot and reverse transcription quantitative polymerase chain reaction (RT‐qPCR) analyses, respectively. The expressions of tight ZO‐1, Occludin, and Claudin‐1 were also measured by western blot assay and immunofluorescence staining. The 16S rRNA gene sequence was used to measure the composition of gut microbiota. The co‐administration of FE and SH improved the body weight, number of fecal pellets, fecal moisture, abdominal with drawal reflex score, and gastrointestinal transit rate in IBS‐C rats. The unique efficacy of combination depended on the regulation of balance between excitatory and inhibitory neurotransmitters, enhancement of intestinal barrier function, and activation of SCF/c‐Kit pathway. The gut microbiota structure was also restored. The ability of FE combined with SH to regulate SCF/c‐Kit signaling pathway, enhance intestinal barrier function, and modulate gut microbiota contributes to their efficacy in managing IBS‐C in rats.
Multiparametric hippocampal signatures for early diagnosis of Alzheimer's disease using 18F‐FDG PET/MRI Radiomics
Authors: Chen Zhigeng , Bi Sheng , Shan Yi , Cui Bixiao , Yang Hongwei , Qi Zhigang , Zhao Zhilian , Han Ying , Yan Shaozhen , Lu Jie 
Published: November 2023

AbstractPurposeThis study aimed to explore the utility of hippocampal radiomics using multiparametric simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) for early diagnosis of Alzheimer's disease (AD).MethodsA total of 53 healthy control (HC) participants, 55 patients with amnestic mild cognitive impairment (aMCI), and 51 patients with AD were included in this study. All participants accepted simultaneous PET/MRI scans, including 18F‐fluorodeoxyglucose (18F‐FDG) PET, 3D arterial spin labeling (ASL), and high‐resolution T1‐weighted imaging (3D T1WI). Radiomics features were extracted from the hippocampus region on those three modal images. Logistic regression models were trained to classify AD and HC, AD and aMCI, aMCI and HC respectively. The diagnostic performance and radiomics score (Rad‐Score) of logistic regression models were evaluated from 5‐fold cross‐validation.ResultsThe hippocampal radiomics features demonstrated favorable diagnostic performance, with the multimodal classifier outperforming the single‐modal classifier in the binary classification of HC, aMCI, and AD. Using the multimodal classifier, we achieved an area under the receiver operating characteristic curve (AUC) of 0.98 and accuracy of 96.7% for classifying AD from HC, and an AUC of 0.86 and accuracy of 80.6% for classifying aMCI from HC. The value of Rad‐Score differed significantly between the AD and HC (p < 0.001), aMCI and HC (p < 0.001) groups. Decision curve analysis showed superior clinical benefits of multimodal classifiers compared to neuropsychological tests.ConclusionMultiparametric hippocampal radiomics using PET/MRI aids in the identification of early AD, and may provide a potential biomarker for clinical applications.