bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teilautomatisierte Generierung von digitalen Infrastrukturmodellen mittels Multi‐Datenfusion
Authors: Jäkel Jan‐Iwo , Gölzhäuser Peter , Schmitt Annette , Bange Justine , Klemt‐Albert Katharina , Reiterer Alexander , Marx Steffen 
Published: October 2023

AbstractDie Eisenbahninfrastruktur besitzt eine hohe Signifikanz für Wirtschaft und Gesellschaft. Das Durchschnittsalter der Eisenbahnbrücken in Deutschland liegt bei etwa 75 Jahren. Entsprechend ist auch die Bestandsdokumentation der Bauwerke historisch bzw. veraltet. Für den Anlagenbetreiber stellt die Inventarisierung, Aktualisierung und Bereitstellung von mehr als 4,6 Millionen Bestandsplänen eine enorme Herausforderung dar. Zudem benötigt die Generation von digitalen Modellen der Brückenbauwerke viele Ressourcen. Diese Faktoren stellen ein gravierendes Problem für ein qualitatives und effizientes Erhaltungsmanagement dar. Im Rahmen des Forschungsprojekts mdfBIM wird eine teilautomatisierte Methode zur Erstellung objektbasierter digitaler Modelle von Bestandsbrücken mittels Multi‐Datenfusion entwickelt. Für diese Methode wird ein ganzheitliches Prozessmodell erarbeitet und die Möglichkeiten einer teilautomatisierten Datenaufnahme und ‐verarbeitung hin zu einem BIM‐Modell als zentrale Datenbasis eruiert. Die Validierung des Ansatzes erfolgt anschließend an einem realen Demonstrator. Der Beitrag zeigt, wie ein teilautomatisierter Ansatz zur Digitalisierung von Bestandsbrückenbauwerken und die Schaffung einer einheitlichen Datengrundlage für das Instandhaltungsmanagement erfolgreich umgesetzt worden sind.
Listeria monocytogenes bacteremia developed during treatment of COVID‐19
Authors: Yamamoto Jin , Nakamoto Keitaro , Shimasaki Teppei , Kurai Daisuke , Saraya Takeshi , Ishii Haruyuki 
Published: October 2023

Key Clinical MessageListeria monocytogenes is an important pathogen in older patients and immunosuppressed patients, often causing bacteremia. Complications resulting from infections other than COVID‐19 must also be considered during COVID‐19 treatment.
Two anti‐Prelog NAD‐Dependent Alcohol Dehydrogenases with Broad Substrate Scope and Excellent Enantioselectivity
Authors: Damian Matteo , Mutti Francesco G. 
Published: October 2023

AbstractEnantiomerically pure alcohols are important to produce active pharmaceutical ingredients, agrochemicals and fine chemicals. Herein, we explored the substrate scope and chemo‐ and enantioselectivity of two NAD‐dependent anti‐Prelog alcohol dehydrogenases from Candida maris (Cm‐ADH) and Pichia finlandica (Pf‐ADH) in the asymmetric reduction of ketones. The ADHs were tested for the reduction of acetophenone with NADH that was recycled using a formate dehydrogenase and sodium formate. Cm‐ADH and Pf‐ADH performed best at 30 °C and at around pH 7 and pH 6, respectively. Pf‐ADH operated well at 50 mM acetophenone concentration, while Cm‐ADH was limited to 10 mM. Regarding the substrate scope, linear‐chain alkyl ketones were efficiently reduced (up to 98 % conversion), while branched and cyclic ketones gave lower conversions (up to 60 %). Aryl‐aliphatic ketones showed variable levels of conversion (<1–79 %), while α,β‐unsaturated and heteroaromatic ketones exhibited good to excellent conversions. In most of the cases, the enantiomeric excess was >99 %. Aliphatic and aryl‐aliphatic aldehydes were converted with up to >99 % conversion. A scale‐up experiment with Pf‐ADH using acetophenone as substrate led to 73 % isolated yield and >99 % ee (R).This work contributes to filling the gap in biocatalytic asymmetric synthesis of chiral alcohols by introducing two NAD‐dependent ADHs with anti‐Prelog selectivity.
Chrysosplenol D can inhibit the growth of prostate cancer by inducing reactive oxygen species and autophagy
Authors: Zhang Haoyu , You Zhixin , Li Yilei , Gao Cheng , Wang Yuhao , Zhang Xiaoxiang 
Published: October 2023

AbstractObjectiveTo uncover the effects of chrysosplenol D (CHD) on the progression of prostate cancer in vitro as well as in mice.MethodsDU145 and PC‐3 cells were treated with increasing doses of CHD for 24, 48, or 72 h. Cell Counting Kit‐8 (CCK‐8) and colony formation assays were conducted to confirm the effects of CHD on cell viability. Flow cytometry (FCM) and immunostaining assays showed the effects of CHD on cell apoptosis and oxidative stress. Immunoblot was performed to detect the effects of CHD on autophagy. Besides, tumor growth assays were conducted to confirm the role of CHD in tumor growth in mice. GraphPad 6.0 was used for statistical analysis. All data were represented as mean ± SD. p < .05 and the significant difference was indicated by an asterisk.ResultsCHD suppressed the viability of prostate cancer cells in CCK‐8 assays, decreased colony number in colony formation assays, and induced cell apoptosis in FCM and immunostaining assays. CHD also restrained the oxidative stress with a decreased 2′‐7′‐dichlorofluorescein diacetate staining intensity. CHD restrained the autophagy of prostate cancer cells, as well as suppressed tumor growth in mice.ConclusionCHD could serve as a drug for prostate cancer.
Estimating seasonal Pacific geoduck clam Panopea generosa show-factors from long-term observation
Authors: Hajas Wayne , Atkins Mike 
Published: October 2023

Abstract

Objective
The geoduck show-factor is the probability an individual geoduck is detectable to a diver during a stock assessment survey. It is one of the values used to estimate the abundance of geoducks. This paper presents estimates of show-factor according to data collected during 21 approximately monthly surveys over a 32-month period. The new estimates are compared against other long-term studies of show-factor and against estimates made from shorter term (approximately daily surveys over a period of approximately 1 week) studies.

Methods
Data were collected from three plots near Marina Island, British Columbia, and three novel methods were used for the analysis. Two of the methods estimate show-factors at the time of data collection, while the third method treats show-factor as a function of the time of year. All three methods generate probabilistic results.

Result
Each method of show-factor analysis indicated a strong seasonal effect. Show-factors were highest from March to June and lowest from October to December. The difference between the high and low show-factors was at least a factor of two. The three methods generated estimates of show-factor that are generally lower than the values previously used as part of stock assessment on the coast of British Columbia.

Conclusion
If this difference between long- and short-term show-factor can be generalized to the many commercial beds on the coast of British Columbia, the abundance of geoducks has been underestimated and the fishery is even more cautious than currently believed. As of yet, long-term data have not been collected on a coastwide basis and conclusions cannot be more definitive.
Fighting for survival: Analyzing strategic trends in arts advocacy
Authors: Meagher Trevor , Bezboruah Karabi , Suh Jiwon 
Published: October 2023

AbstractAmerican arts organizations are locked in a continuous fight for their survival as a result of their demanding operational contexts. Virtually every arts organization engages in some form of formal or informal advocacy in order to raise public awareness and secure financial support or political goodwill. While there are almost as many different advocacy strategies as there are arts organizations, studies that trace changes in strategic employment over time are rare, as advocates are typically focused on present issues and the immediate future. This research seeks to address this knowledge gap. Through a systematic review of over 260 scholarly sources, editorials, blogs, think pieces, and miscellaneous other pro‐arts arguments, this article identifies five main arguments for supporting the arts that have been commonly used by arts advocates since the inception of the National Endowment for the Arts. This article presents a theoretical typology that is useful for understanding these arguments and the thematic connections between them. It concludes with a discussion of general trends towards strategic isomorphism and research sophistication among these strategies, then offers avenues for future research that may assist arts advocates with evaluating strategies' success so as to improve their future effectiveness.
Persistence of pulmonary hypertension in patients undergoing ventricular assist devices and orthotopic heart transplantation
Authors: Rajaratnam Arun , El‐Swais Ameen , McTiernan Charles , Thoma Floyd W. , Baghal Moaaz O. , Raffensperger Kristen , Chang Chung‐Chou H. , Hickey Gavin W. , Shah Faraaz A. , Al Ghouleh Imad 
Published: October 2023

AbstractPulmonary hypertension (PH) is common in advanced heart failure and often improves quickly after left ventricular assist device (VAD) implantation or orthotopic heart transplantation (OHT), but long‐term effects and outcomes are not well‐described. This study evaluated PH persistence after VAD as destination therapy (VAD‐DT), bridge to transplant (VAD‐OHT), or OHT‐alone. The study constituted a retrospective review of patients who underwent VAD‐DT (n = 164), VAD‐OHT (n = 111), or OHT‐alone (n = 138) at a single tertiary‐care center. Right heart catheterization (RHC) data was collected pre‐, post‐intervention (VAD and/or OHT), and 1‐year from final intervention (latest‐RHC) to evaluate the longitudinal hemodynamic course of right ventricular function and pulmonary vasculature. PH (Group II and Group I) definitions were adapted from expert guidelines. All groups showed significant improvements in mean pulmonary artery pressure (mPAP), pulmonary artery wedge pressure (PAWP), cardiac output, and pulmonary vascular resistance (PVR) at each RHC with greatest improvement at post‐intervention RHC (post‐VAD or post‐OHT). PH was reduced from 98% to 26% in VAD‐OHT, 92%−49% in VAD‐DT, and 76%−28% in OHT‐alone from preintervention to latest‐RHC. At latest‐RHC mPAP remained elevated in all groups despite normalization of PAWP and PVR. VAD‐supported patients exhibited suppressed pulmonary artery pulsatility index (PaPi < 3.7) with improvement only posttransplant at latest‐RHC. Posttransplant patients with PH at latest‐RHC (n = 60) exhibited lower survival (HR: 2.1 [95% CI: 1.3−3.4], p < 0.001). Despite an overall significant improvement in pulmonary pressures and PH proportion, a notable subset of patients exhibited PH post‐intervention. Post‐intervention PH was associated with lower posttransplant survival.
A novel condition‐based maintenance policy considering imperfect switching for warm standby systems
Authors: Qi Faqun , Wang Yunke , Wang Xisha , Wu Yao 
Published: October 2023

AbstractThis paper proposes a novel condition‐based maintenance model for a two‐component warm standby system considering an imperfect switching policy. Unlike the conventional models, joint optimization of preventive and failure switching strategies is investigated. The standby component can be switched preventively when the component reaches the preventive maintenance (PM) threshold before the online one fails. The failure switching is triggered when the online component reaches the corrective maintenance (CM) threshold. In addition, the switching mechanism between the two components is related to the order fulfillment rate. The optimal PM threshold and order fulfillment rate can be derived by minimizing the long‐term average cost rate. A numerical example is provided to demonstrate the robustness of the decision model under different scenarios through sensitivity analysis. Ultimately, the effectiveness of the proposed model in this article was verified by comparing the models.
Falsche ,,Hirntod‘‘-Feststellung in Deutschland
Authors: Beckmann Rainer 
Published: October 2023

ZusammenfassungDer sogenannte ,,Hirntod‘‘ ist in Deutschland als Todeszeichen weitgehend anerkannt. Seine Feststellung
anhand von Richtlinien der Bundesärztekammer gilt als sicher. Der Fall einer abgebrochenen ,,Hirntod‘‘-Feststellung
aus dem Jahr 2014 zeigt jedoch, dass die damals geltenden Richtlinien korrekturbedürftig waren. Eine
genauere Überprüfung der aktuellen Regeln zur Feststellung des ,,Hirntodes‘‘ ergibt, dass auch
sie Mängel und Ungereimtheiten enthalten. Insbesondere verstoßen die Richtlinien gegen die Begründungspflicht
gem. §16 Abs. 2 S. 2 TPG.
Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies
Authors: Islam Md. Rezaul , Dhar Puja Sutro , Akash Shopnil , Syed Sabeena Hussain , Gupta Jeetendra Kumar , Gandla Kumaraswamy , Akter Muniya , Rauf Abdur , Hemeg Hassan A. , Anwar Yasir , Aljohny Bassam Oudh , Wilairatana Polrat 
Published: October 2023

AbstractHypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN, with an emphasis on the molecular mechanisms of action found in substances found in plants, herbs, and seafood. Bioactive molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN remedies. Recent advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure (BP)-regulating effects of these natural substances better. Polyphenols, flavonoids, alkaloids, and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone, reducing oxidative stress (OS), reducing inflammation, and improving endothelial function. The article explains the vasodilatory, diuretic, and renin–angiotensin–aldosterone system (RAAS) modifying properties of vital plants such as garlic and olive leaf. Phytochemicals from plants are the primary in traditional drug development as models for novel antihypertensive drugs, providing diverse strategies to combat HTN due to their biological actions. The review also discusses the functions of calcium channel blockers originating from natural sources, angiotensin-converting enzyme (ACE) inhibitors, and nitric oxide (NO) donors. Including seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat HTN. Omega-3 fatty acids, peptides, and minerals obtained from seafood sources have anti-inflammatory, vasodilatory, and antioxidant properties that improve vascular health and control BP. Overall, we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.
Improving community health volunteers’ knowledge on cervical cancer using dialogue-based training in rural Kisumu County
Authors: Ochomo Edwin Onyango , Masinde David , Ouma Collins 
Published: October 2023

Abstract
Background
The global burden of cervical cancer continue to rise with the low- and middle-income countries bearing the greatest burden. East Africa recorded about 54560 cases and 36497 deaths attributed to cervical cancer in 2020 with 5236 cases and 3211 deaths being reported annually. This high burden can be attributed to low screening rates and late diagnosis, which lead to undesirable outcomes. Kenya still has low screening rates with only 16.4% of the eligible women screened against the WHO target of 70% by 2030. Kisumu has a lower screening rate of about 5.7% according to KHIS 2019 data. This low screening rate is due to lack of proper community health education. We evaluated the effectiveness of dialogue-based training in improving community health volunteers’ (CHV) knowledge on cervical cancer in Nyando.

Methods
The study adopted a pre-and-post, longitudinal study design. The CHVs knowledge was assessed before and after the training. We calculated the proportion net change in the number of CHVs with improved knowledge after the intervention. Statistical significance was assessed at p ≤ 0.05.

Results
The pre-test mean score was 30.1%, this improved to 53.4% at post-test following the dialogue-based training of the CHVs. The knowledge on the various aspects: risk factors (p < 0.0001), signs and symptoms (p < 0.0001) and screening (p < 0.0001) significantly improved at the post-test following the dialogue-based training. The overall score also significantly improved (p < 0.0001) following the training among the CHVs. Occupation (p < 0.0001) was found to be significantly associated with knowledge on cervical cancer.

Conclusion
The CHVs’ knowledge was inadequate but significantly improved following the dialogue-based training.
Orientations de facilitation pour soutenir l’application de l’Algo dans les services de soutien à domicile des personnes aînées
Authors: Ruest Mélanie , Guay Manon 
Published: October 2023

RésuméComment soutenir le déploiement de connaissances coconstruites par des personnes cliniciennes, gestionnaires ou chercheures? Ce thème est abordé à partir de l’étude de l’application de l’Algo, un algorithme clinique décisionnel conçu pour la sélection des aides techniques visant à faciliter l’hygiène corporelle des personnes aînées vivant à domicile. L’objectif de cette note sur les politiques et les pratiques est de présenter les orientations de facilitation dégagées à la suite d’un devis mixte multiphases (2015–2019) mis en œuvre dans les services de soutien à domicile au Québec (Canada). Les orientations de facilitation centrée sur la tâche et holistique sont présentées en fonction des stades d’utilisation de l’Algo, afin de soutenir les personnes cliniciennes, gestionnaires et chercheures dans la poursuite de son application auprès des personnes aînées. De plus, cette note illustre l’apport des devis mixtes à la conduite et à la compréhension de l’application des connaissances coconstruites.
ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides
Authors: Cerella Claudia , Gajulapalli Sruthi Reddy , Lorant Anne , Gerard Deborah , Muller Florian , Lee Yejin , Kim Kyung Rok , Han Byung Woo , Christov Christo , Récher Christian , Sarry Jean-Emmanuel , Dicato Mario , Diederich Marc 
Published: October 2023

AbstractMyelomonocytic and monocytic acute myeloid leukemia (AML) subtypes are intrinsically resistant to venetoclax-based regimens. Identifying targetable vulnerabilities would limit resistance and relapse. We previously documented the synergism of venetoclax and cardiac glycoside (CG) combination in AML. Despite preclinical evidence, the repurposing of cardiac glycosides (CGs) in cancer therapy remained unsuccessful due to a lack of predictive biomarkers. We report that the ex vivo response of AML patient blasts and the in vitro sensitivity of established cell lines to the hemi-synthetic CG UNBS1450 correlates with the ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1)/BCL2 like 1 (BCL2L1) expression ratio. Publicly available AML datasets identify myelomonocytic/monocytic differentiation as the most robust prognostic feature, along with core-binding factor subunit beta (CBFB), lysine methyltransferase 2A (KMT2A) rearrangements, and missense Fms-related receptor tyrosine kinase 3 (FLT3) mutations. Mechanistically, BCL2L1 protects from cell death commitment induced by the CG-mediated stepwise triggering of ionic perturbation, protein synthesis inhibition, and MCL1 downregulation. In vivo, CGs showed an overall tolerable profile while impacting tumor growth with an effect ranging from tumor growth inhibition to regression. These findings suggest a predictive marker for CG repurposing in specific AML subtypes.
Monolithic full-color active-matrix micro-LED micro-display using InGaN/AlGaInP heterogeneous integration
Authors: Qi Longheng , Li Peian , Zhang Xu , Wong Ka Ming , Lau Kei May 
Published: October 2023

AbstractA prototype of full-color active-matrix micro-light-emitting diode (micro-LED) micro-display with a pixel density of 391 pixel per inch (ppi) using InGaN/AlGaInP heterogeneous integration is demonstrated. InGaN blue/green dual-color micro-LED arrays realized on a single metal organic chemical vapor deposition (MOCVD)-grown GaN-on-Si epiwafer and AlGaInP red micro-LED arrays are both monolithically fabricated, followed by the integration with a common complementary metal oxide semiconductor (CMOS) backplane via flip-chip bonding technology to form a double-layer thin-film display structure. Full-color images with decent color gamut and brightness are successfully displayed through the fine adjustment of driving current densities of RGB subpixels. This full-color display combines the advantages of high quantum efficiency of InGaN material on blue/green light and AlGaInP material on red light through heterogeneous integration and high pixel density through monolithic fabrication approach, demonstrating the feasibility and prospects of high brightness, good color performance, and high-resolution micro-LED micro-displays in future metaverse applications.
Miniature integrated spectrometers towards high-performance and cost-effective
Authors: Sun Haoxuan , Zhou Yicheng , Li Liang 
Published: October 2023

AbstractThe conjugated mode of bound states in a continuum is integrated as a narrowband wavelength extraction unit. A low-cost and easy-to-prepare strategy, using solution-processable semiconductors, has been demonstrated to form a new platform for on-chip spectral analysis.
Spatiotemporal mode-locking and dissipative solitons in multimode fiber lasers
Authors: Cao Bo , Gao Chenxin , Liu Kewei , Xiao Xiaosheng , Yang Changxi , Bao Chengying 
Published: October 2023

AbstractMultimode fiber (MMF) lasers are emerging as a remarkable testbed to study nonlinear spatiotemporal physics with potential applications spanning from high energy pulse generation, precision measurement to nonlinear microscopy. The underlying mechanism for the generation of ultrashort pulses, which can be understood as a spatiotempoal dissipative soliton (STDS), in the nonlinear multimode resonators is the spatiotemporal mode-locking (STML) with simultaneous synchronization of temporal and spatial modes. In this review, we first introduce the general principles of STML, with an emphasize on the STML dynamics with large intermode dispersion. Then, we present the recent progress of STML, including measurement techniques for STML, exotic nonlinear dynamics of STDS, and mode field engineering in MMF lasers. We conclude by outlining some perspectives that may advance STML in the near future.