bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of Biomechanical, Anthropometric, and Demographic Factors Associated with Patellofemoral Pain in Rearfoot Strike Runners: A Classification and Regression Tree Approach
Authors: de Souza Júnior José Roberto , Gaudette Logan Walter , Johnson Caleb D. , Matheus João Paulo Chieregato , Lemos Thiago Vilela , Davis Irene S. , Tenforde Adam S. 
Published: January 2024

Abstract
Background
Patellofemoral pain (PFP) is among the most common injuries in runners. While multiple risk factors for patellofemoral pain have been investigated, the interactions of variables contributing to this condition have not been explored. This study aimed to classify runners with patellofemoral pain using a combination of factors including biomechanical, anthropometric, and demographic factors through a Classification and Regression Tree analysis.

Results
Thirty-eight runners with PFP and 38 healthy controls (CON) were selected with mean (standard deviation) age 33 (16) years old and body mass index 22.3 (2.6) kg/m2. Each ran at self-selected speed, but no between-group difference was identified (PFP = 2.54 (0.2) m/s x CON = 2.55 (0.1) m/s, P = .660). Runners with patellofemoral pain had different patterns of interactions involving braking ground reaction force impulse, contact time, vertical average loading rate, and age. The classification and regression tree model classified 84.2% of runners with patellofemoral pain, and 78.9% of healthy controls. The prevalence ratios ranged from 0.06 (95% confidence interval: 0.02–0.23) to 9.86 (95% confidence interval: 1.16–83.34). The strongest model identified runners with patellofemoral pain as having higher braking ground reaction force impulse, lower contact times, higher vertical average loading rate, and older age. The receiver operating characteristic curve demonstrated high accuracy at 0.83 (95% confidence interval: 0.74–0.93; standard error: 0.04; P < .001).

Conclusions
The classification and regression tree model identified an influence of multiple factors associated with patellofemoral pain in runners. Future studies may clarify whether addressing modifiable biomechanical factors may address this form of injury.
Applying task supported language learning via instagram: the effects on EFL learners' self-esteem, academic buoyancy, academic engagement, and language achievement
Authors: Ibrahim Khaled Ahmed Abdel-Al , Basim Nirvana 
Published: January 2024

AbstractResearchers have firm reason to unlock the potential of social networking technologies today because of the rapid development of these platforms, which may be used to enhance educational outcomes. Despite the widespread recognition of social media's influence on the second/foreign language learning process, few empirical research has attempted to find out how Instagram feed-based tasks impact learning and supported self-esteem, academic buoyancy (AB), academic engagement (AE), and language achievement (LA). In order to address this knowledge gap, the present study investigated how Instagram feed-based assignments may be used to improve self-esteem, AB, AE, and LA for EFL students. This was accomplished by randomly assigning participants into two groups (experimental and control) from a pool of 93 intermediate EFL students. Students in the control group (CG) participated in online webinars on a consistent basis. Students in the experimental group (EG) took part online webinars. Moreover, they were given assignments based on Instagram feeds. The Multivariate Analysis of Variance (MANOVA) of the data showed that the EG fared better than the CG. The findings underlined the substantial benefits of Instagram feed-based activities in promoting self-esteem, AB, AE, and LA. Possibilities for future use of Instagram task supported language learning and teaching may arise as a result of this study's implications for students, educators, and policymakers.
Cartilage-like protein-polysaccharide hybrid hydrogel for enhancing chondrogenic differentiation of bone marrow mesenchymal stem cells
Authors: Zhang Xinyue , Zhan Xue , Cheng Haojin , Dong Zuqin , Hu Chen , Liu Chenxin , Liang Jie , Chen Yafang , Fan Yujiang , Zhang Xingdong 
Published: January 2024

AbstractThe regeneration of articular cartilage posed a formidable challenge due to the restricted treatment efficacy of existing therapies. Scaffold-based tissue engineering emerges as a promising avenue for cartilage reconstitution. However, most scaffolds exhibit inadequate mechanical characteristics, poor biocompatibility, or absent cell adhesion sites. In this study, cartilage-like protein-polysaccharide hybrid hydrogel based on DOPA-modified hyaluronic acid, bovine type I collagen (Col I), and recombinant humanized type II collagen (rhCol II), denoted as HDCR. HDCR hydrogels possessed the advantage of injectability and in situ crosslinking through pH adjustment. Moreover, HDCR hydrogels exhibited a manipulable degradation rate and favorable biocompatibility. Notably, HDCR hydrogels significantly induced chondrogenic differentiation of rabbit bone marrow mesenchymal stem cells in vitro, as demonstrated by the upregulation of crucial chondrogenic genes (type II collagen, aggrecan) and the abundant accumulation of glycosaminoglycan. This approach presented a strategy to manufacture injectable, biodegradable scaffolds based on cartilage-like protein-polysaccharide polymers, offering a minimally invasive solution for cartilage repair.
Graphical abstract
MTHFR (C677T) polymorphism and its association with cytogenetic and clinical profile in individuals with primary amenorrhea
Authors: Sanghavi Priyanka M. , Chandel Divya 
Published: January 2024

Abstract
Background
Abnormal folate metabolism is a risk factor for DNA hypomethylation and chromosomal nondisjunction. MTHFR is a candidate gene for folliculogenesis and ovarian development. In the present study, we aimed to investigate the distribution of the MTHFR C677T polymorphism in individuals with primary amenorrhea and it’s association with the cytogenetic and clinical profile. The MTHFR polymorphism (C677T) was checked in 45 females with PA and 45 control females (age-matched) with regular menstrual cycles using polymerase chain reaction-restriction fragment length polymorphism.

Results
We observed the CC genotype in 84.4% (n = 38) of the control group females and 48.9% (n = 22) of the case group females, CT genotype in 13.3% (n = 6) in the control group females and 24.4% (n = 11) in the case group females (p = 0.039; χ2 value 4.253; odd ratio 0.316, 95%CI 0.103–0.973) and TT genotype in 2.2% (n = 1) in the control group females and 26.7% (n = 12) in the case group females (p = 0.000266; χ2 value 13.294; odd ratio 0.048, 95%CI 0.006–0.397). Out of 45 case group females, 26 females showed 46,XX karyotype, 4 females showed male karyotype, 3 females showed pure Turner karyotype, 2 females were mosaic Turner and the rest of the females showed structural abnormalities like deletion, isochromosome and normal variants. The serum values revealed significantly lower levels (p = 0.032) of progesterone in the individuals with the TT genotype as compared to the CC genotype and the radiology profile showed a significant role of the MTHFR gene in ovarian development (p = 0.024).

Conclusion
We suggest that the MTHFR polymorphism (C677T) might be responsible for the chromosomal nondisjunction in monosomy X females. It also influences the progesterone level and ovarian development, thus affecting folliculogenesis and the ovarian reserve responsible for primary amenorrhea.
Differentiating multiple sclerosis from cerebral small vessel disease using diffusion tensor imaging and magnetic resonance spectroscopy on normally appearing thalami
Authors: elsalam Sahar Mahmoud Abd , Salah Soheir , Said Ahmed Hesham , Hussein Mona , Magdy Rehab , Osama Wesam 
Published: January 2024

Abstract
Background
Diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (1H-MRS) can detect the microstructural changes in normal-appearing conventional MRI. So, they may differentiate between multiple sclerosis (MS) cases and cerebral small vessel disease (CSVD). This work aimed to investigate if MRS and DTI are helpful in differentiating between MS and CSVD cases.

Methods
The study was conducted on 90 subjects divided into three groups: 30 relapsing–remitting MS patients, 30 patients with MRI showing CSVD, and 30 healthy controls. Diffusion tensor imaging measuring thalamic FA, ADC values, and 1H-MRS were conducted on patients and controls.

Results
Thalamic FA values were significantly higher in the RRMS group than in the control and CSVD groups (P < 0.001, for each) but significantly lower in the CSVD group than the control group (P < 0.001). Moreover, thalamic ADC values were significantly higher in the CSVD group than in the control and MS groups (P < 0.001, for each). Also, thalamic NAA values were significantly lower in RRMS and CSVD groups than in controls (P < 0.001 for each). Still, they were significantly lower in the RRMS group than the CSVD group only on the left side (P = 0.004). The thalamic NAA/Cr values were significantly lower in RRMS (P < 0.001 for both sides) and CVSD than in controls (P = 0.044 and 0.036, for RT and LT sides, respectively).

Conclusions
Thalamic DTI and 1H-MRS can help detect the microstructural changes in normal-appearing thalami in RRMS and CSVD patients. Moreover, they can help differentiate MS from CSVD patients.
Structural optimization and performance improvement of rock drill seals based on orthogonal test
Authors: Jia Chunqiang , Wang Aofei , Zong Li , Yu Ling 
Published: January 2024

AbstractThe drill tail of a rock drill meets high-frequency fretting in both the rotational and axial axes. The pure water seal is prone to damage and failure owing to its difficult working features and the low viscosity of the water medium. Orthogonal testing is used to simulate and model the Y-shaped seal ring to enhance the performance of the water seal. The maximum contact stress and maximum Von Mises stress are selected as indicators of sealing effectiveness based on an assessment of the effects of different seal section parameters on sealing performance. These insights serve to improve the building of the water seal. Maximum contact stress is demonstrated to be linked to lip thickness and chamfer length, but inversely proportional to lip length. Meanwhile, the maximum Von Mises stress is directly influenced by lip depth, including the angle of the lip and drill tail, and is inversely linked to lip thickness. Maximum contact stress and maximum Von Mises stress are lowered by 15% and 45%, respectively, in the revised Y-shaped water seal, resulting in greatly better sealing performance.
Disparities in National Cancer Institute and Nonprofit Organization Funding Disproportionately Affect Cancers With Higher Incidence Among Black Patients and Higher Mortality Rates
Authors: Kamath Suneel D. , Chen Yanwen 
Published: January 2024

PURPOSE National Cancer Institute (NCI) and nonprofit organization (NPO) funding is critical for research and advocacy but may not be equitable across cancers. METHODS This study evaluated funding from the NCI and NPOs supporting lung, breast, colorectal, pancreatic, hepatobiliary, prostate, ovarian, cervical and endometrial cancers, leukemia, lymphoma, and melanoma from 2015 to 2018. The primary objectives were to assess for funding disparities across different cancers compared with their incidence and mortality and across racial groups. We also determined if underfunding correlates with fewer clinical trials. Correlations between funding for each cancer and its incidence, mortality, and number of clinical trials were analyzed using descriptive statistics and Pearson correlation coefficients (CCs). RESULTS Diseases with the largest combined NCI and NPO funding were breast cancer ($3.75 billion in US dollars [USD]) and leukemia ($1.99 billion USD). Those with the least funding were endometrial ($94 million USD), cervical ($292 million USD), and hepatobiliary cancers ($348 million USD). Disease-specific funding correlated well with incidence but correlated poorly with mortality (Pearson CCs, 0.74; P = .006 and .30, P = .346, respectively). Breast cancer, leukemia, and lymphoma were well-funded while colorectal, lung, hepatobiliary and uterine cancers were underfunded. Higher incidence among Black patients correlated with underfunding. The amount of funding for a particular cancer correlated strongly with the number of clinical trials for that disease (Pearson CC, 0.91; P < .0001). CONCLUSION Many cancers with high incidence and mortality rates are underfunded. Cancers that affect Black patients at higher rates are also underfunded. Underfunding strongly correlates with fewer clinical trials, which could impede future advances in underfunded cancers.
Costs to Medicare of Nonrecommended Bone-Modifying Agent Use for Castration-Sensitive Prostate Cancer
Authors: Mitchell Aaron P. , Nemirovsky David , Mishra Meza Akriti , Chakraborty Nirjhar , Persaud Sonia , Farooki Azeez , Morris Michael J. 
Published: January 2024

PURPOSE Bone-modifying agents (BMAs) do not prevent skeletal-related events among patients with castration-sensitive prostate cancer (CSPC), but many patients receive BMAs unnecessarily. The costs to Medicare from overuse have not been assessed. METHODS We used linked SEER-Medicare data 2011-2015 to measure the frequency and number of doses of zoledronic acid (ZA) and denosumab received during CSPC (between diagnosis and initiation of metastatic, castration resistant prostate cancer therapy). We estimated excess BMA among patients who received BMA therapy for CSPC and did not have an indication for osteoporosis fracture prevention. We used the Medicare fee schedule for drug prices and peer-reviewed sources to estimate adverse event frequencies and costs. RESULTS Median CSPC duration was 387 days (IQR, 253-573), during which time 42% of patients received ≥one dose of denosumab (mean doses, 7) and 18% received ≥one dose of ZA (mean doses, 7). Thirty-eight percent of those receiving denosumab and 47% of those receiving ZA had a history of osteoporosis, osteopenia, spine or hip fracture, or hypercalcemia. The estimated, annual excess BMA cost to Medicare was $44,105,041 in US dollars (USD), composed of $43,303,078 USD and $45,512 USD in drug costs for denosumab and ZA, respectively, and $682,865 USD and $75,585 USD in adverse event costs, respectively. In one-way sensitivity analysis, the estimate was most sensitive to denosumab dosing frequency (estimate range, $28,469,237 USD-$98,830,351 USD) and duration of CSPC (estimate range, $36,823,311 USD-$99,015,908 USD). CONCLUSION BMA overuse in CSPC incurs substantial cost to Medicare, largely because of denosumab drug costs. Excess costs may be reduced by greater adherence to guideline-concordant BMA use.
Environmental impact on visual perception modulates behavioral responses of schooling fish to looming predators
Authors: Rodriguez-Pinto Ivan I. , Rieucau Guillaume , Handegard Nils Olav , Boswell Kevin M. , Theobald Jamie C. 
Published: January 2024

ABSTRACT
Aggregation in social fishes has evolved to improve safety from predators. The individual interaction mechanisms that govern collective behavior are determined by the sensory systems that translate environmental information into behavior. In dynamic environments, shifts in conditions impede effective visual sensory perception in fish schools, and may induce changes in the collective response. Here, we consider whether environmental conditions that affect visual contrast modulate the collective response of schools to looming predators. By using a virtual environment to simulate four contrast levels, we tested whether the collective state of minnow fish schools was modified in response to a looming optical stimulus. Our results indicate that fish swam slower and were less polarized in lower contrast conditions. Additionally, schooling metrics known to be regulated by non-visual sensory systems tended to correlate better when contrast decreased. Over the course of the escape response, schools remained tightly formed and retained the capability of transferring social information. We propose that when visual perception is compromised, the interaction rules governing collective behavior are likely to be modified to prioritize ancillary sensory information crucial to maximizing chance of escape. Our results imply that multiple sensory systems can integrate to control collective behavior in environments with unreliable visual information.
Cardiovascular responses and the role of the neurohumoral cardiac regulation during digestion in the herbivorous lizard Iguana iguana
Authors: Guagnoni Igor Noll , Armelin Vinicius Araújo , da Silva Braga Victor Hugo , Monteiro Diana Amaral , Florindo Luiz Henrique 
Published: January 2024

ABSTRACT
Carnivorous reptiles exhibit an intense metabolic increment during digestion, which is accompanied by several cardiovascular adjustments responsible for meeting the physiological demands of the gastrointestinal system. Postprandial tachycardia, a well-documented phenomenon in these animals, is mediated by the withdrawal of vagal tone associated with the chronotropic effects of non-adrenergic and non-cholinergic (NANC) factors. However, herbivorous reptiles exhibit a modest metabolic increment during digestion and there is no information about postprandial cardiovascular adjustments. Considering the significant impact of feeding characteristics on physiological responses, we investigated cardiovascular and metabolic responses, as well as the neurohumoral mechanisms of cardiac control, in the herbivorous lizard Iguana iguana during digestion. We measured oxygen consumption rate (O2), heart rate (fH), mean arterial blood pressure (MAP), myocardial activity, cardiac autonomic tone, fH/MAP variability and baroreflex efficiency in both fasting and digesting animals before and after parasympathetic blockade with atropine followed by double autonomic blockade with atropine and propranolol. Our results revealed that the peak of O2 in iguanas was reached 24 h after feeding, accompanied by an increase in myocardial activity and a subtle tachycardia mediated exclusively by a reduction in cardiac parasympathetic activity. This represents the first reported case of postprandial tachycardia in digesting reptiles without the involvement of NANC factors. Furthermore, this withdrawal of vagal stimulation during digestion may reduce the regulatory range for short-term fH adjustments, subsequently intensifying the blood pressure variability as a consequence of limiting baroreflex efficiency.
Management of Malocclusion in Children Using Myobrace Appliance: A Systematic Review
Authors: Achmad Harun , Auliya Nurul 
Published: January 2024

Background: Bad oral habits are common in children aged less than six years and can stop spontaneously. If these bad habits continue after the age of six years, it can cause malocclusion. In the world of pediatric dentistry, one of the treatments for malocclusion is Oral Myofunctional Therapy (OMT). One of the myofunctional tools that can be used to correct malocclusion as well as bad habits in children is the Myobrace Appliance - an intraoral device system used in interceptive orthodontics. The purpose of this systematic review is to explore the management of malocclusion in children using the Myobrace Appliance. Methods: The data was collected by a literature search on Google Scholar, including articles published from 2016 to 2020. The data search was carried out systematically using the keywords Malocclusion in Children and Myobrace Appliance. After eliminating duplicate articles, the titles and abstracts of each article were analyzed across 108 articles, resulting in 51 articles. There were 36 articles not in line with topic and 6 articles which could not be freely accessed, so that 42 articles were excluded. The full text articles in the other nine articles were reanalyzed; three articles were excluded with reason and six articles were produced which were then included in the analysis. Results: There are six articles that discuss the management of malocclusion in children using the Myobrace appliance. All of these explain that Myobrace appliance is effective in handling cases of malocclusion especially to correct class II malocclusion and class III malocclusion. Conclusion: Myobrace appliance can be used as an alternative treatment for malocclusion in children, especially to correct class II and III malocclusion (mandibular prognathy and maxillary retrognathy). Additionally, this tool is capable of correcting overbite, overjet, crowding of upper and lower anterior teeth, sagittal molar relationships, lip seals, and facial asymmetry.
Exploring residents’ perceptions of competency-based medical education across Canada: A national survey study
Authors: Braund Heather , Patel Vivesh , Dalgarno Nancy , Mann Steve 
Published: January 2024

Background: As Competency-Based Medical Education (CBME) is implemented across Canada, little is known about residents’ perceptions of this model. This study examined how Canadian residents understand CBME and their lived experiences with implementation. Methods: We administered a survey in 2018 with Likert-type and open-ended questions to 375 residents across Canada, of whom 270 were from traditional programs (“pre-CBME”) and 105 were in a CBME program. We used the Mann-Whitney test to examine differences across samples, and analyzed qualitative data thematically. Results: Three themes were identified across both groups: program outcome concerns, changes, and emotional responses. In relation to program concerns, both groups were concerned about the administrative burden, challenges with the assessment process, and feedback quality. Only pre-CBME residents were concerned about faculty engagement and buy-in. In terms of changes, both groups discussed a more formalized assessment process with mixed reactions. Residents in the pre-CBME sample reported greater concerns for faculty time constraints, assessment completion, and quality of learning experiences, whilst those in CBME programs reported being more proactive in their learning and greater self-reflection. Residents expressed strong emotional narrative responses including greater stress and frustration in a CBME environment. Conclusion: Findings demonstrate that residents have mixed feelings and experiences regarding CBME. Their positive experiences align with the aim of developing more self-directed learners. However, the concerns suggest the need to address specific shortcomings to increase buy-in, while the emotional responses associated with CBME may require a cultural shift within residency programs to guard against burnout.