bluuebunny/crossref_metadata_2025_split huggingface dataset:
Over-expression of small ubiquitin-like modifier proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer
Authors: Mu Juwei , Zuo Yong , Yang Wenjing , Chen Zhaoli , Liu Ziyuan , Tu Jun , Li Yan , Yuan Zuyang , Cheng Jinke , He Jie 
Published: January 2024

BackgroundNon-small cell lung cancer (NSCLC) is one of the most common malignant tumors. Despite the advances in therapy over the years, its mortality remains high. The aim of this study was to evaluate the expression of small ubiquitin-like modifier (SUMO) proteases 1 (SENP1) in NSCLC tissues and its role in the regulation of vascular endothelial growth factor (VEGF) expression. We also investigated the association between the expression level of SENP1 and the clinicopathological features and survival of the patients.MethodsA SENP1 small interfering RNA (siRNA) was constructed and transfected into the NSCLC cells.VEGFgene expression was analyzed by real-time polymerase chain reaction (RT-PCR). Immunohistochemistry staining was used to assess the expression of SENP1 in 100 NSCLC patients and its association with the clinicopathological features and survival was analyzed.ResultsVEGF expression was significantly higher in NSCLC tissues than in normal lung tissues. Inhibition of SENP1 by siRNA was associated with decreased VEGF expression. SENP1 was over-expressed in 55 of the 100 NSCLC samples (55%) and was associated with a moderate and low histological tumor grade (3.6%, 38.2%, and 58.2% in high, moderate and low differentiated tumors, respectively,P=0.046), higher T stage (10.9% in T1, and 89.1% in T2 and T3 tumor samples,P<0.001) and TNM stage (10.9% in stage I, and 89.1% in stages II and III tumor samples,P<0.001). The rate of lymph node metastasis was significantly higher in the SENP1 over-expression group (76.4%) than that in the SENP1 low expression group (33.3%,P<0.001). Sixty three patients received postoperative chemotherapy, including 34 with SENP1 over-expression and 29 with SENP1 low expression. Among the 34 patients with SENP1 over-expression, 22 (64.7%) patients developed recurrence or metastasis, significantly higher than those in the low expression group 27.6% (8/29) (P=0.005). Multivariate Cox regression analysis showed that lymph node metastasis (P=0.015), TNM stage (P=0.001), and SENP1 expression level (P=0.002) were independent prognostic factors for the survival of NSCLC patients.ConclusionsSENP1 may be a promising predictor of survival, a predictive factor of chemo-sensitivity for NSCLC patients, and potentially a desirable drug target for lung carcinoma target therapy.
Ability of lower teardrop edge to restore anatomical hip center height in total hip arthroplasty
Authors: Lu Yufeng , Cheng Liming , Guo Wanshou , Yu Qingsheng , Gao Fuqiang , Zhang Qidong , Liu Zhaohui , Sun Wei , Shi Zhencai 
Published: January 2024

Background
The acetabular teardrop is often used to guide acetabular component placement in total hip arthroplasty (THA). Placing the lower acetabular component aspect at the same level as the lower teardrop edge was assumed to restore the hip center of rotation. Here we radiographically analyzed the relationship between cup center and normal contralateral acetabulum center height on unilateral THA using this placement method.

Methods
A total of 106 unilateral THA cases with normal contralateral acetabula were reviewed and the vertical and horizontal distances in relation to the lower acetabular teardrop edge from both hip joint centers, cup inclination, and anteversion were measured radiographically. The paired t-test was used to compare left and right hip center heights. Scatter plots and Pearson's correlation coefficients were used to evaluate differences in hip center heights, cup anteversion, inclination angles, and medialized cup center distance compared to the contralateral hip joint.

Results
Cup center height was significantly greater (P <0.01) than contralateral hip joint center height (93.4% in the 0–5 mm range, 6.6% >5 mm). There was a weak correlation between hip center height difference and inclination (r=0.376, P <0.01) and between difference and anteversion (r=0.310, P <0.01) but no correlation between difference and outer cup diameter (r=0.184, P=0.058) or difference and medialized cup center distance (r=-0.098, P=0.318).

Conclusions
Although this method did not exactly replicate anatomic hip center height, the clinical significance of cup center height and anatomic hip center height differences is negligible. This acetabular component placement method has high simplicity, reliability, and stability.
New disease severity classification of patients with stable chronic obstructive pulmonary disease in Shanghai
Authors: Guogang Xie , Yingying Zhang , Xin Zhou 
Published: January 2024

Background
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) presented a new ABCD group classification of chronic obstructive pulmonary disease (COPD). We aimed to examine the association of spirometric classification and the new GOLD classification with exacerbations, and to compare symptoms in different ways.

Methods
We investigated 848 patients with stable COPD from 24 hospitals. The annual frequencies of acute exacerbation and hospitalization were compared between the old and new classification. The symptom level was assessed using COPD assessment test (CAT) and modified British Medical Research Council (mMRC) questionnaire.

Results
A total of 848 patients were included in this study. According to spirometric classification, there were 32 patients of grade I (3.8%), 315 of grade II (37.1%), 366 of grade III (43.2%), and 135 of grade IV (15.9%). According to GOLD 2011 classification, there were 59 patients of group A (7.0%), 172 of group B (20.3%), 55 of group C (6.5%), and 562 of group D (66.3%). In spirometric classification, the annual frequencies of acute exacerbation and associated hospitalization were respectively 1 (0–3) and 0 (0–2) for grade I; 1 (0–5) and 0 (0–2) for grade II; 2 (0–6) and 1 (0–3) for grade III, and 3 (0–6) and 2 (0–3) for grade IV. In GOLD 2011, respectively 0 (0–3) and 0 (0–1) (group A), 1 (0–4) and 0 (0–3) (group B), 1 (0–5) and 0 (0–3) (group C), and 3 (0–6) and 1 (0–3) (group D). There were no significant difference between group B and C (Z= -1.347, P=0.178; Z= -0.772, P=0.440, respectively). The coincidence rate using mMRC=1 and CAT=10 as cutoff points was 86.6% (734/848, κ=0.706), compared with 77.9% (661/848, κ=0.60) using mMRC=2 and CAT=10.

Conclusions
Lung function test may be a better predictor of acute exacerbation and associated hospitalization of COPD. It is more appropriate to use mMRC=1 as cutoff point for assessing COPD symptoms.
Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-small cell lung cancer
Authors: Caiqing Zhang , Xiaoyan Lin , Yinghua Song , Xiaofang Zhang , Hongjia Li , Qiangxiu Wang 
Published: January 2024

BackgroundGlucosylceramide synthase (GCS), an enzyme responsible for ceramide glycosylation, plays an important role in multidrug resistance (MDR) in some tumorsin vitro; however, its expression and clinicopathological significance in non-small cell lung cancer (NSCLC) remains unclear.MethodsWe evaluated GCS expression in 116 paired tumor and adjacent non-cancerous tissues and 50 frozen tissues from patients with NSCLC using immunohistochemistry and western blotting, and explored the correlation between GCS and NSCLC clinicopathological characteristics and prognosis. We observed the association between GCS and the MDR proteins P-glycoprotein (P-gp) and lung resistance-related protein (LRP) to determine the link between GCS and MDR at the histological level.ResultsGCS expression was significantly upregulated in NSCLC tumors compared with non-cancerous tissue. There was high GCS expression in 75/116 tumor specimens (64.7%) and 16/116 non-cancerous specimens (13.8%). High GCS expression was significantly associated with poor differentiation (P=0.01), lymph node metastasis (P=0.004), recurrence/ distant metastasis (P=0.006), and chemotherapy resistance (P=0.025). Multivariate analysis demonstrated that GCS immunopositivity was an independent risk factor for survival (P=0.018). P-gp was expressed in 80/116 tumors (69.0%) and in 12/116 non-cancerous tissue specimens (10.3%;P=0.001); LRP was expressed in 85/116 tumors (73.3%) and 19/116 non-cancerous tissue specimens (16.4%;P=0.001). Importantly, the results demonstrated that increased GCS expression in NSCLC cancer specimens correlated with increased expression of P-gp and LRP, molecules known to stimulate cancer cell MDR (r=0.612 and 0.503,P=0.01 and 0.035, respectively).ConclusionGCS upregulation might contribute to the development of NSCLC and could be a useful prognostic indicator and chemoresistance predictor for NSCLC patients.
Interaction of sleep quality and sleep duration on glycemic control in patients with type 2 diabetes mellitus
Authors: Yunzhao Tang , lingling Meng , Daiqing Li , Min Yang , Yanjuan Zhu , Chenguang Li , Zhenhuan Jiang , Ping Yu , Zhu Li , Hongna Song , Changlin Ni 
Published: January 2024

Background
Copious evidence from epidemiological and laboratory studies has revealed that sleep status is associated with glucose intolerance, insulin resistance, thus increasing the risk of developing type 2 diabetes. The aim of this study was to reveal the interaction of sleep quality and sleep quantity on glycemic control in patients with type 2 diabetes mellitus.

Methods
From May 2013 to May 2014, a total of 551 type 2 diabetes patients in Tianjin Metabolic Diseases Hospital were enrolled. Blood samples were taken to measure glycosylated hemoglobin (HbA1c), and all the patients completed the Chinese version of the Pittsburgh Sleep Quality Index (PSQI) questionnaire to evaluate their sleep status. “Good sleep quality” was defined as PQSI <5, “average sleep quality” was defined as PQSI 6–8, and “poor sleep quality” was defined as PQSI >8. Poor glycemic control was defined as HbA1c ≥7%. Sleep quantity was categorized as <6, 6–8, and >8 hours/night. Short sleep time was defined as sleep duration <6 hours/night.

Results
In the poor glycemic control group, the rate of patients who had insufficient sleep was much higher than that in the other group (χ2=11.16, P=0.037). The rate of poor sleep quality in poor glycemic control group was much greater than that in the average control group (χ2=9.79, P=0.007). After adjusted by gender, age, body mass index, and disease duration, the adjusted PSQI score's OR was 1.048 (95% CI 1.007–1.092, P=0.023) for HbA1c level. The sleep duration's OR was 0.464 (95% CI 0.236–0.912, P=0.026) for HbA1c level. One-way analysis of variance showed that the poor sleep quality group had the highest homeostasis model assessment-insulin resistance (P <0.01).

Conclusions
Inadequate sleep, in both quality and quantity, should be regarded as a plausible risk factor for glycemic control in type 2 diabetes. Poor sleep might bring much more serious insulin resistance and could be the reason for bad glycemic control. A good night's sleep should be seen as a critical health component tool in the prevention and treatment of type 2 diabetes. It is important for clinicians to target the root causes of short sleep duration and/or poor sleep quality.
Virus profile in children with acute respiratory infections with various severities in Beijing, China
Authors: Zhu Runan , Song Qinwei , Qian Yuan , Zhao Linqing , Deng Jie , Wang Fang , Sun Yu 
Published: January 2024

Background
Acute respiratory infection (ARI) is one of the most common infectious diseases in infants and young children globally. This study aimed to determine the virus profile in children with ARI presenting with different severities.

Methods
Clinical specimens collected from children with ARI in Beijing from September 2010 to March 2011 were investigated for 18 respiratory viruses using an xTAG Respiratory Viral Panel Fast (RVP Fast) assay. The Pearson chi-square analysis was used to identify statistical significance.

Results
Of 270 cases from three groups of ARI patients, including Out-patients, In-patients and patients in the intensive care unit (ICU), viruses were detected in 176 (65.2%) specimens with the RVP Fast assay. The viral detection rate from the Out-patients group (50.0%) was significantly lower than that from the In-patients (71.1%) and ICU-patients (74.4%) groups. The virus distribution was different between the Out-patients group and the other hospitalized groups, while the virus detection rate and distribution characteristics were similar between the In-patients and ICU-patients groups. The co-infection rates of the Out-patients group, the In-patients group, and the ICU-patients group were 15.6%, 50.0% and 35.8%, respectively. In addition to respiratory syncytial virus (RSV) and adenovirus (ADV), human rhinovirus (HRV) was frequently detected from children with serious illnesses, followed by human metapneumovirus (hMPV), human bocavirus (HBoV) and coronaviruses. Parainfluenza virus 3 (PIV3) was detected in children with lower respiratory illness, but rarely from those with serious illnesses in the ICU-patient group.

Conclusion
In addition to so-called common respiratory viruses, virus detection in children with ARI should include those thought to be uncommon respiratory viruses, especially when there are severe ARI-related clinical illnesses.
Proximal gastric cancer: lymph node metastatic patterns according to different T stages dictate surgical approach
Authors: Song Wu , Liu Yuyi , Ye Jinning , Peng Jianjun , He Weiling , Chen Jianhui , Chen Chuangqi , He Yulong 
Published: January 2024

Background
As a common form of gastric cancer migration, lymph node metastasis largely affects the surgical treatment and prognosis of gastric cancer. Surgery is the fundamental curative option for gastric cancer that varies depending on different stages. The study aimed to compare the clinicopathological characteristics and lymph node metastatic patterns in patients of proximal gastric cancer with different T stages and investigate a reasonable radical gastrectomy approach in terms of the range of lymphadenectomy for proximal gastric cancer.

Methods
In our retrospective study, the data of 328 patients of proximal gastric cancer with different T stages were analyzed. By comparing the differences of lymph node metastatic rate and ratio, we investigated the clinicopathological characteristics and metastatic patterns of lymph nodes. Also, we were especially interested in the differences in survival rates between patients with and without No. 5 and 6 group metastasis with the same TNM stage.

Results
The overall lymph node metastatic rate and ratio of advanced proximal gastric cancer were 73.4% and 23.3%, respectively. The tumors of different T stages were statistically significant in size and differentiation degree (P <0.05), multivariate analysis showed that the depth of tumor invasion was an independent risk factor for lymph node metastasis in proximal gastric cancer (RR, 12.025; 95% CI, 2.326 to 62.157; P=0.003). The overall survival rate of patients with No. 5, 6 group lymph node metastasis and those without was significantly different, but the differences in survival rates between patients with and without No. 5 and 6 group metastasis with the same TNM stage were not statistically significant.

Conclusions
Different T stages in proximal gastric cancer showed different patterns and characteristics of lymph node metastasis. D2 lymphadenectomy in patients with early gastric cancer had little survival benefit because metastasis to level 2 nodes was rare. Therefore the range of the lymph node dissection in radical gastrectomy for early gastric cancer was considered reasonable. Moreover, to meet the requirements of the lymph node dissection, total gastrectomy plus D2 lymphadenectomy or more are supposed to be applied for the advanced proximal gastric cancer patients. Precise T staging largely determines the range of gastrectomy and lymphadenectomy.
Incidence and risk factors analysis of heterotopic ossification after cervical disc replacement
Authors: Qi Min , Chen Huajiang , Cao Peng , Tian Ye , Yuan Wen 
Published: January 2024

Background
Cervical disc replacement (CDR) as a substitute for traditional fusion surgery has been widely used in treating degenerative cervical disc diseases. The objectives of this study were to assess the clinical and radiological findings for patients with heterotopic ossification (HO) following CDR and to detect the risk factors of HO after CDR.

Methods
A total of 125 patients with symptomatic cervical single- or double-level disc diseases, who underwent CDR procedure with Discover prosthesis in Department of Spine Surgery, Changzheng Orthopedics Hospital from March 2009 to March 2011, were enrolled in this retrospective study. Occurrence of HO was defined by the McAfee classification on cervical lateral X-rays in this study. Prosthesis vertebral ratio (PVR) was used to determine the matching degree between the cervical disc prosthesis and cervical vertebra. Logistic regression analyses were performed to determine the risk factors of HO. Variables evaluated for their association with HO occurrence included age, gender, high-intensity signal in spinal cord, preoperative range of motion (ROM), postoperative ROM, operation level number, and PVR.

Results
Mean follow-up time was (26.4±5.8) months. All the patients had significant symptoms and neurological function improvements during the follow-up period. The ROM of the operated segment from the preoperative period to the last follow-up was relatively well maintained. The rate of HO in this cohort of patients, who underwent Discover disc, was 27.92% per surgical level and 24.8% per patient by the last follow-up. There were 19 patients (19.79%) with HO in the single-level group while 12 patients (41.38%) in the double-level group.

Conclusions
We identified preoperative high-intensity signal in spinal cord, postoperative ROM of surgical level, number of operation level, and PVR as significant risk factors for postoperative HO occurrence.
Pelatihan Perancangan Dekorasi Motif Kerudung Dengan Aplikasi Surface Design Mix Material Embellishment
Authors: Siagian Marissa Cory , Sekar Fardhani Ahda Yunia , Takao Gina Shobiro 
Published: January 2024

Berkembangnya industri Muslim Indonesia hal tersebut terlihat dari berkembangnya trend fashion dan industry khususnya busana Muslim lahir dari local brand Indonesia. Perkembangan ini tidak terlepas dari sumber daya manusia yang terlibat, maka diperlukan upaya pengembangan wawasan dan kemampuan ketrampilan sumber daya manusianya sehingga meningkatkan kompetensi yang dimiliki, khususnya membangun potensi anak muda Indonesia.
Dalam kegiatan pengabdian masyarakat ini kami melihat adanya potensi pengembangan keahlian kepada beberapa anak muda khususnya para santri dan masyarakat Pesantren Sirojul Huda Parung- Serab, Soreang, Jawa Barat. Dengan berbekal kemampuan menjahit dasar, fasilitas mesin jahit, perlu pengembangan keterampilan dalam menciptakan produk yang berkaitan dengan kebutuhan berbusana Muslim berupa pengembangan kerudung yang sesuai dengan trend fashion busana Muslim saat ini. Pelatihan yang diharapkan kedepannya para santri dan masyarakat sekitarnya dapat ikut menjadi pelaku industri Busana Muslim Indonesia. Pelatihan ini berupa pendampingan transfer ilmu dengan memberikan pengetahuan, keterampilan berupa wawasan teknik elemen dan material dekorasi Teknik kriya desain kerudung sesuai dengan trend saat ini. Besar harapan dengan kegiatan ini potensi, keterampilan dan pengetahuan masyarakat sasar sekitar berkembang dan dapat diimplementasikan dalam indutri Muslim sehingga kedepannya mendapat pekerjaan layak serta peningkatan ekonomi baik bekerja berkemlompok maupun individual baik indutri kecil maupun garmen.

Kata kunci: Busana Muslim, Kerudung, Trend.
Küçük Kaynarca Sonrası Osmanlı-Rus Müzakerelerinden Bir Kesit: 1776 Tarihli Mükâleme Belgesi
Authors: Ünlü Ertan 
Published: January 2024

1768-1774 Osmanlı Rus Savaşı, sonuçları açısından Osmanlı İmparatorluğu için bir dönüm noktasıdır. Çünkü 21 Temmuz 1774’te imzalanan Küçük Kaynarca Antlaşması, Kırım’ın bağımsızlığı ve Osmanlı İmparatorluğu’nun savaş tazminatı ödemesi gibi ağır şartlar barındırmaktadır. Bu bağlamda Küçük Kaynarca Antlaşması, her ne kadar iki devlet arasındaki savaşı bitirmiş olsa da içerdiği belirsizliklerle yeni sorunların çıkmasına temel teşkil etmiştir. Zira Rusya, antlaşmayı gerekçe göstererek, İstanbul dışında konsolosluk açma, Karadeniz’de Osmanlı aleyhine ticari faaliyet yürütme, Kırım’ı ilhaka yönelme gibi çeşitli girişimlerde bulunmuştur. Bu nedenle iki devlet beynindeki sular, Küçük Kaynarca sonrasında bir türlü durulmamıştır. Bu da Osmanlı İmparatorluğu ile Rusya arasında Aynalıkavak Tenkihnamesi’ne kadar devam eden yoğun bir müzakere sürecine yol açmıştır.
Burada neşrettiğimiz ve Osmanlı Arşivi’nde Yıldız Esas Evrakı tasnifi içinde 91/44 numara ile kayıtlı olan mükâleme belgesi de bu sürecin bir ürünüdür. Bu belge, Küçük Kaynarca Antlaşması sonrasında Osmanlı İmparatorluğu ile Rusya arasındaki ilişkiler açısından önem arz etmektedir. İlgili belge, Reisülküttap Raif İsmail Efendi’nin Rusya orta elçisi Aleksandr Stachieviç Stachiev’le Kuzguncuk’taki yalısında 7 Mayıs 1776’daki görüşmesinde yönelttiği on iki maddelik sorular temelinde şekillenmiştir. Bu sorular, reayanın durumu, kiliseler, tazminat ödemeleri, Tatarların durumu gibi konular hakkındadır. Fakat Stachiev devletine danışması gerektiğinden, Raif İsmail Efendi’ye hemen cevap verememiştir. Dolayısıyla Rusya’dan beklenen yanıt ancak 15 Eylül 1776’da gelmiştir.
Çukurova Âyânları IV: Hasanpaşazâde Ahmet Bey II
Authors: Kurt Yılmaz 
Published: January 2024

18. Yüzyıl Çukurova’da âyânlığın en güçlü olduğu yıllardır. Adana valilerinin Rumeli’de bulunan kale ve şehirlerin korunması için görevlendirilmiş olması, şehirlerin mütesellimler eliyle yönetilmesi sonucunu doğurdu. İşte bölgenin güçlü âyân ailesi Karslızâdeler veya daha sonraki adıyla Hasanpaşazâdeler 1750 yılından sonra böyle bir tablo içerisinde ortaya çıkmış ve bölgenin yönetiminde etkili olmuştu. 1770 yılında Karslızâde Hasan Paşa’nın Üzeyir sancakbeyi olarak atanmasından sonra aile, Hasanpaşazâdeler olarak anılmaya başlamıştır. Hasanpaşazadeler, Adana Müftüsü İshak Efendi üzerinden Ramazanoğulları kimliği ile Cumhuriyete intikal etmiş köklü bir âyân ailesidir.
Hasanpaşazâdeler âyân ailesi ve bu ailenin en güçlü ismi Ahmet Bey hakkında bugüne kadar bazı akademik yayınlar yapılmıştır. 1793-1811 yılları arasında birçok defa Adana mütesellimliği yapan Ahmet Bey hakkında, gerek Adana Şer’iye Sicillerinde ve gerekse diğer Osmanlı Arşiv kaynaklarında yüzlerce belge bulunmaktadır. 57 numaralı Adana Şer’iye Sicili neredeyse tamamen Ahmet Bey ile ilgilidir. Bu belgeler sadece Çukurova bölge tarihi ve âyânlık mücadeleleri ile ilgili olmayıp Nizâm-ı Cedîd uygulamaları ve mâlikâne-mukataa işletmelerinin nasıl yürütüldüğü konusunda da değerli bilgiler sunmaktadır. Bundan önceki makalemizde Ahmet Bey’in mütesellimliğe atanması konusunda gerekli bilgiler verilmiş olduğundan biz burada yayınlamış olduğumuz belgelerin değerlendirilmesine ağırlık vermek istiyoruz.
Buraya aldığımız 71 belge Hasanpaşazâde Ahmet Bey’in 1798 yılından1802 yılına kadar olan mütesellimlik dönemlerine ilişkin belgelerdir. Bu dönem, Napolyon’un Mısır saldırısı yılları olduğundan yayınlanan belgeler bu savaşın arka planı konusunda çok kıymetli bilgiler sunmaktadır. Adana’da âyân ailelerinin mukataa ve malikâneleri nasıl ele geçirdiğini ve bu yolla bölgedeki hakimiyetlerini nasıl güçlendirdiklerini gösteren birçok belge araştırmacılara ulaştırılmış olmaktadır[1] .