bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare Complications of Infective Endocarditis in Marfan Morphotype: Diagnosis of Multiple Mitral Valve Aneurysms and Aortic Root Abscess using Three- Dimensional Transesophageal Echocardiography
Authors: Boumaaz Meriem , Lahjouji Mohamed Reda , Faraj Raid , Mouine Najat , Asfalou Iliyasse , Benyass Aatif 
Published: December 2023

Abstract
Mitral valve aneurysm (MVA) is characterized by a saccular outpouching of the mitral leaflet, and it represents a rare condition typically associated with aortic valve endocarditis. Three-Dimensional Transesophageal Echocardiography (3D-TEE) serves as an effective tool for detecting the presence of MVA and its potential complications. In this report, we present a case involving a young man with striking images of bicuspid aortic valve endocarditis complicated by an aortic root abscess and multiple perforated mitral valve aneurysms, diagnosed using 3D TEE. This case suggests the uncommon coexistence of Marfan syndrome, bicuspid aortic valve, and infective endocarditis as a triple mechanism in the occurrence of MVA. It underscores the significance of early and accurate imaging diagnosis for facilitating prompt surgical intervention.
Partial Coherence Analysis for Vibration Signal and Noise Signal of Braking System of Hoist
Authors: Hao Xuedi , Ding Yaotian , Zhang Jiajin , Zhang Chenze , Liu Bing , Zhang Yixuan 
Published: December 2023

Abstract
In present study, the correlation between vibration signal and noise signal produced by disc brake of mine hoist was investigated. Based on the theory of geometry and motion similarity, the braking system was simplified and a brake test-bed was established in the laboratory. The data of 12 sets of vibration signals and 6 sets of noise signals at three rotational speeds were collected. The 1/3-octave analysis and the partial coherence analysis was used to identify noise sources under different working conditions. The test results showed that the noise source of the faulty brake was located at the brake flange seat and the noise source of the normal brake was located at the brake caliper, which laid a theoretical foundation for the further use of vibration and noise signals for the diagnosis of faults with insufficient disc brake braking force and the health management of mine hoists.
Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells
Authors: Yamada Hideyuki , Takada Mamoru , Ghone Dhaval , Yu Muhan , Nagashima Takeshi , Fujimoto Hiroshi , Sakakibara Junta , Hasegawa Yoshie , Takao Shintaro , Yamada Akimitsu , Narui Kazutaka , Ishikawa Takashi , Suzuki Aussie , Otsuka Masayuki 
Published: December 2023

Abstract

Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore ERI's effects on the cGAS-STING pathway. Additionally, the nuclear presence of cGAS remains poorly understood. This study uniquely delves into ERI's impact on both the cytosolic cGAS-STING pathway and nuclear cGAS. ERI enhances nuclear localization of cGAS, resulting in hyper-activation of the cGAS-STING pathway in triple-negative breast cancer cells. Reduction of cGAS heightened both cell proliferation and ERI sensitivity. In clinical data using ERI in a neo-adjuvant setting, patients with low cGAS cases exhibited reduced likelihood of achieving pathological complete response after ERI treatment. These findings illuminate the potential of cGAS and IFNβ as predictive biomarkers for ERI sensitivity, providing valuable insights for personalized breast cancer treatment strategies.
Analysis of the impact of underlying diseases in the elderly on postoperative re-fractures after osteoporotic compression fractures
Authors: LI Qingwei , Bao QI , ，KONG Xiangqing , ，MENG Chunyang 
Published: December 2023

Abstract
Background
Postoperative refracture of osteoporotic compression fractures in the elderly due to underlying illnesses is a complicated matter involving several variables. A multidisciplinary approach involving orthopedics, geriatrics, endocrinology, and rehabilitation medicine is necessary for an investigation of these issues. investigating the impact of older patients' underlying medical conditions on the refracture of osteoporotic compression fractures following surgery.
Methods
A retrospective analysis was conducted on 2383 patients between August 2013 and August 2023. 550 patients with comorbid geriatric underlying diseases were screened, 183 patients underwent refractories, and 367 patients were classified as non-refractories. The patients were then divided into two groups: those undergoing refractories and those not, and the underlying diseases of the patients in both groups were examined using ROC curves and unifactorial and multifactorial logistic regression analyses.
Results
Among the patients gathered, the frequency of re-fracture was 33.3%. A statistically significant difference was observed when re-fracture was linked to patients with long-term alcohol consumption, operated vertebrae ≤ 1, hypertension, COPD, diabetes mellitus, stroke sequelae, conservative treatment of coronary heart disease, trauma, mental abnormality, scoliosis, and chronic renal disease. Having hypertension decreased the risk of re-fracture (P = 0.018, OR = 0.548), while alcohol intake ≥ 10years (P = 0.003, OR = 2.165), mental abnormality (P < 0.001, OR = 4.093), scoliosis (P < 0.001, OR = 6.243), chronic kidney disease (P = 0.002, OR = 2.208), and traumatic injuries (P = 0.029, OR = 3.512) were the risk factors examined in a binary logistic regression analysis. The results of multiple linear stepwise regression analysis indicated that re-fracture was more influenced by scoliosis.
Conclusions
Hypertensive disorders were protective factors against the formation of re-fracture, while alcohol intake usage for more than ten years, psychological abnormalities, scoliosis, chronic kidney disease, and trauma were risk factors. Scoliosis had the highest influence on re-fracture.
Geostress-associated settlements of a raft-foundation building due to shield tunnelling in soft ground
Authors: Zhang Tianqi , Li Zhenkun , Wang Ruikun , Zheng Gang , Lei Huayang , Fan Qi 
Published: December 2023

Abstract

The stress state of the soil, i.e., geostress, may affect the settlements of a building induced by the tunneling, which, however, has not been well understood. In this study, 3D numerical analyses combined with in-situ measurements were performed to investigate the geostress-associated settlements of a raft-foundation building due to shield tunnelling in soft ground. Basically, two types of geostress fields were investigated: the first type of geostress field considered the effect of additional stress generated in the foundation soil (FAS) due to weight of building; while in the second type of geostress field, a sequential twin tunnelling process was presumed, and the effect of the additional soil stress induced by the first tunnel (TAS) on the building response to the second tunnel was considered. The results indicated that the presence of FAS may aggravate the stress release of the foundation soil during a shield tunnelling, and thus gave rise to a larger building settlement or inclination. In a sequential tunnelling process, the effect of TAS can be more complex: when the first tunnel lowered the stress of the foundation soil, the TAS effect of the first tunnel may help reduce the building settlements induced by the second tunnel; otherwise, it may aggravate the building settlements. In addition to the TAS effect, the sheltering effect was also found to play an important part in the sequential twin-tunnelling. Especially when the first tunnel was positioned between the building and the second tunnel, the building settlements induced by the second tunnel can be impeded.
Exchange graphs and Ext-quivers of hearts of tube categories
Authors: Chen Mingfa 
Published: December 2023

Abstract
In this paper we introduce the notion of pre-simple-minded collection (pre-SMC) of type A in the bounded derived categories Db (Tp) of tube categories Tp of rank p. This provides an effective approach to classify the hearts in Db (Tp). We then use this classification to prove the exchange graph of hearts in Db (Tp) is connnected. Further, we classify the Ext-quivers of hearts in Db (Tp). As an application, we show that the space of Bridgeland stability conditions on Db (Tp) is connected.
2020 Mathematics Subject Classification. 18E40, 18E10, 18G80, 16G20, 16G70, 16E35, 14F45.
Automatic segmentation and classification of frontal sinuses for sex determination from CBCT scans using a two-stage anatomy-guided attention network: A study of the South Korean population
Authors: Silva Renan Lucio Berbel , Yang Su , Kim Dael , Kim Jun Ho , Lim Sang-Heon , Han Jiyong , Kim Jun-Min , Kim Jo-Eun , Huh Kyung-Hoe , Lee Sam-Sun , Heo Min-Suk , Yi Won-Jin 
Published: December 2023

Abstract

Sex determination is essential for identifying unidentified individuals, particularly in forensic contexts. Traditional methods for sex determination involve manual measurements of skeletal features on CBCT scans. However, these manual measurements are labor-intensive, time-consuming, and error-prone. The purpose of this study was to automatically and accurately determine sex on a CBCT scan using a two-stage anatomy-guided attention network (SDetNet). SDetNet consisted of a 2D frontal sinus segmentation network (FSNet) and a 3D anatomy-guided attention network (SDNet). FSNet segmented frontal sinus regions in the CBCT images and extracted regions of interest (ROIs) near them. Then, the ROIs were fed into SDNet to predict sex accurately. To improve sex determination performance, we proposed multi-channel inputs (MSIs) and an anatomy-guided attention module (AGAM), which encouraged SDetNet to learn differences in the anatomical context of the frontal sinus between males and females. SDetNet showed superior sex determination performance in the area under the receiver operating characteristic curve, accuracy, Brier score, and specificity compared with the other 3D CNNs. Moreover, the results of ablation studies showed a notable improvement in sex determination with the embedding of both MSI and AGAM. Consequently, SDetNet demonstrated automatic and accurate sex determination by learning the anatomical context information of the frontal sinus on CBCT scans.
EFFEC: The Efficient Edge-Caching System for Multimedia Communication
Authors: Malaioni Jofantus Ferdi , Bachtiar Moch. Aril , Baswara Muhammad Raihan , Yovita Leanna Vidya , Wibowo Tody Ariefianto , Hertiana Sofia Naning 
Published: December 2023

Abstract
The widespread use of social media with multimedia content and the development of sophisticated and interactive websites affect internet traffic growth. User requests for the same multimedia content cause an increase in the core network load. For this reason, an elegant solution is needed. Instead of supplying additional network capacity, we automatically put content closer to the user. Commonly, a proxy server is used only to monitor the data sent or for load-balancing purposes. However, in our research, proxy servers are exploited to keep the copies of content users request. So that, we not only take advantage of the monitoring and security functions on the proxy server but also take advantage of its ability to store data. We name our proposed system as EFFEC, the efficient edge-caching system that can be used for multimedia communication. This system allows the request for content not to be forwarded to the original server located further away from the user. This strategy provides an efficient communication system. We have successfully built the edge cache system for multimedia communication. The evaluation result shows that using edge caching methods by utilizing a proxy server offers significant improvements in increasing speed, reducing load on the server, and delays.
A Nomogram-Based Malignancy Risk Assessment Model for Breast Masses Upgraded from BI-RADS 1-3 in Mammography to Category 4 in Supplemental Ultrasound for Women with Dense Breasts
Authors: Li Cheng , Luo Yong , Jiang Yan , Wu Xumiao , Li Qi 
Published: December 2023

Abstract
Background
Mammography, the primary breast cancer screening method, exhibits high false-negative rates in women with dense breasts. Supplemental ultrasound increases cancer detection sensitivity but also raises the number of unnecessary biopsies due to its low positive predictive value (PPV).
Objective
This study aims to develop a predictive model for assessing the malignancy risk of breast masses initially categorized as BI-RADS 1–3 in mammography but upgraded to BI-RADS 4 in supplemental ultrasound in women with dense breasts. The aim was to enhance the PPV of supplemental ultrasound, thereby reducing unnecessary biopsies.
Methods
A retrospective analysis was conducted to identify breast masses that met specific inclusion and exclusion criteria. These masses were then randomly divided into training and validation sets. Pathological, radiological, and clinical data of the breast masses were systematically collected. Using the LASSO algorithm, key variables were identified in the training set, which facilitated the development of a logistic regression model, along with a corresponding nomogram. The model’s efficacy was assessed in both the training and validation sets, using metrics such as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), ROC curves, calibration curves, and decision curve analysis.
Results
Of the 11,051 women screened, 425 masses met the study criteria. The LASSO algorithm identified ultrasonic characteristics, such as mass size, shape, margin, calcifications, and vascularity as significant predictors. The model demonstrated high discriminative power, with AUCs of 0.908 and 0.882 for the training and validation sets, respectively, and robust calibration. The PPV in the training set increased significantly from 0.178 to 0.556 and in the validation set from 0.213 to 0.561. The model also showed high NPVs, sensitivity, and specificity.
Conclusion
The study successfully developed a predictive model and corresponding nomogram for evaluating malignancy risk in a specific subset of breast masses. Validated for accuracy and clinical utility, the model significantly improves the PPV of supplemental ultrasound, indicating a potential reduction in unnecessary biopsies. It represents a promising advance in personalized breast cancer screening for women with dense breasts.
A novel compound heterozygous PCDH15 variants may be associated with arRP in a Chinese pedigree
Authors: Yang Hong , Zhang Ya-juan , Zhu Li , Zheng Wei-yi , Shi Mei-yu , Zhao Hong-chao 
Published: December 2023

Abstract

Background
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal diseases. However, it is still not well understand about the relationship between PCDH15 mutations and RP.
Methods
In this study, we enrolled a Chinese autosomal recessive retinitis pigmentosa (arRP) pedigree and identified the causative gene in the proband by targeted whole exome sequencing(WES).The mutations were validated in the family members by Sanger sequencing and co-segregation analysis.
Results
Novel compound heterozygous, deleterious missense variants of the PCDH15 gene, NM_001384140.1:c.4368 − 2147_4368-2131del and c.2505del(p.T836Lfs*6), were identified in the arRP pedigree, which co-segregated with the clinical RP phenotypes. The PCDH15 protein is highly conserved among species.
Conclusion
This is the first study to identify novel compound heterozygous mutations c.4368 − 2147_4368-2131del and c.2505del(p.T836Lfs*6) in the PCDH15 gene which might be disease-causing mutations, thereby extending the mutational spectra. All above findings will contribute to genetic counseling, molecular diagnosis and clinical management of arRP disease.
Using HD-EMG to Assess Motor Units in Vastus Lateralis with the Lokomat: A Pilot Study with Healthy and Stroke Individuals
Authors: Corvini Giovanni , Lorusso Matteo , Tagliamonte Nevio Luigi , Masciullo Marcella , Molinari Marco , Scivoletto Giorgio , Tamburella Federica , Moreno Juan C. 
Published: December 2023

Abstract
Background: Recent advancements in surface electromyography (EMG) technology have led to new solutions including multiple electrodes placed over a single muscle, indicated as High-Density EMG (HD-EMG). From this technology, by extracting the Motor Unit (MU) properties, more information can be obtained. Despite its growing research presence, HD-EMG has yet to gain widespread acceptance in routine clinical evaluations, particularly for the assessment of age-related variations and central nervous system disorders. This pilot study aims to evaluate the feasibility of using a portable HD-EMG system in daily clinical settings, in particular using the Lokomat, to study MU properties in both young and elderly healthy as well as stroke individuals.
Methods: In this pilot study, we recruited 9 participants: 3 Healthy Young (2 males, 1 female, 28.33 ± 6.80 years), 3 Healthy Elderly (2 males, 1 female, 58.66 ± 3.05 years) and 3 Chronic Stroke Survivors (2 males, 1 female, 59 ± 6.24 years). We asked participants to perform isometric sub-maximal contractions at three different force levels within the Lokomat, a widely used device in neurorehabilitation. A portable 64-channels High-Density EMG was used to acquire myoelectrical signals.
Results: Our findings suggest that while traditional EMG amplitude and spectral parameters fail to identify differences among healthy control groups, HD-EMG effectively can capture age-related variations through the analysis of Motor Unit properties, specifically in the number of extracted MUs.Moreover, in contrast to the simple parameters typically used by clinicians, distinct neuromuscular alterations associated with stroke were detected through MU property analysis when comparing stroke-affected individuals with healthy groups. Results highlight the possibility to explore specific neuromuscular changes with HD-EMG.
Conclusion: This pilot study shows the advantages of integrating HD-EMG into clinical test sessions with the Lokomat. Through the study of MU properties, HD-EMG provides valuable insights into muscle behavior, which could potentially advance our understanding of neuromuscular conditions and effectively optimize the rehabilitation treatments. We believe that further research should be performed in this direction to establish HD-EMG as a standard clinical diagnostic.
A Cross-Sectional Assessment of Food Supplement Practices and the Relationship Between Anxiety and Interest in Nutrition in Adults During COVID-19 Pandemic
Authors: Özkan Gülin Öztürk , Canyolu Burcu Aksoy , Lanpir Aslı Devrim , Güzeldere Hatice Kübra Barcın , İltaç Havvanur Yoldaş , Güler Kübra Yıldız , Güneş Fatma Esra 
Published: December 2023

Abstract
Purpose
Food supplement usage increased during the COVID-19 pandemic. The aim of this study was to examine food supplement use and associated factors during the pandemic among adults.
Methods
This study was conducted between August -September 2021 in 3546 adults. A questionnaire containing a total of 39 questions was applied for socio-demographic characteristics, COVID-19 infection status, and food supplement use. The questionnaire also included the Depression and Anxiety Stress Scale consisting of 21 questions. Descriptive data was presented as mean and standard deviation and the Chi-square test was applied for comparison of categorical data. Multiple regression analyses and linear regression were applied for food supplement likelihood analysis.
Results
Food supplement usage was 37.1% during the pandemic. Participants with mild anxiety and moderate anxiety were less likely to use food supplements than individuals with extremely severe anxiety. It was observed that the most common food supplements used by adults during the pandemic were vitamin D, vitamin C, and multivitamins. It was observed that the likelihood of using vitamin C, vitamin D, multivitamins, omega-3, B group vitamins, and zinc supplements increased in individuals interested in nutrition during the pandemic. It was determined that the likelihood of using vitamin C, vitamin D, multivitamins, and B group vitamin supplements increased with upper anxiety levels.
Conclusion
Food supplement use increased among adults during COVID-19. In addition, the type of food supplement has also been affected by COVID-19. During the pandemic, the likelihood of food supplement use increased with the increase in anxiety levels.
Symmetry Breaking and Chiral Amplification in Prebiotic Ligation Reactions
Authors: Deng Min , Yu Jinhan , Blackmond Donna G. 
Published: December 2023

Abstract

A general rationalization of the single chirality of biological molecules, a signature of life, remains a challenging goal. 1 Research has commonly focused on initial symmetry breaking and subsequent enantioenrichment of monomeric building blocks – sugars and amino acids – that comprise the genetic polymers RNA, DNA, and peptides. If these building blocks are only partially enantioenriched, however, stalling of chain growth may result, whimsically termed in the case of nucleic acids as “the problem of original syn”.2 In studying a novel prebiotically plausible route to proteinogenic peptides reported by Powner,3-5 we discovered that the reaction favors the ligation of l monomers with d monomers. While this finding appears problematic for the prebiotic emergence of homochiral peptides, we demonstrate, paradoxically, that this heterochiral preference provides a mechanism for enantioenrichment in homochiral chains. Symmetry breaking, chiral amplification, and chirality transfer processes occur for all reactants and products in multicomponent competitive reactions even when only one of the molecules in the complex mixture is non-racemic. The low solubility of mixed heterochiral compounds acts as a further purification of the solution phase. Experimental data and kinetic modeling support this prebiotically plausible mechanism for the emergence of homochiral biological polymers.
Seismic vulnerability assessment of concrete-filled steel built-up column building
Authors: Tiwari Pramod , Jain Kranti 
Published: December 2023

Abstract
To check the effect of earthquake in composite material as concrete filled steel box (CFSB) column; mainly three combinations of the column-beam (Pre-existing RCC building, CFSB column-steel beam and CFSB column-RC beam) structure is compared. Using response spectrum analysis in numerical FE software, the seismic effect was examined for all three combinations. It is determined that the CFSB column-steel beam combination is appropriate for high seismic effect. The RCC building and the CFSB column-steel beam building have also undergone seismic fragility analyses. For seismic-resistant constructions, lateral load carrying capability and collapse prevention are improved when the time history and fundamental time period of response spectra match. The CFSB structures have a three-fold greater peak ground acceleration (PGA) tolerance than RCC buildings in an Incremental dynamic analysis (IDA) comparison, with the difference in damage propagation during operational (OP) phases being negligible. Therefore, it is determined that the building having CFSB column-steel beam combination is safe in comparison.