bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: An Experimental Study on Quantitative Evaluation of Cognitive Features in Indian College Students with Yoga and Rajyoga Meditation as Intervention
Authors: Madhu Shobhika , KUMAR PRASHANT , CHANDRA SUSHIL 
Published: November 2023

Abstract

Background: The current study reported the stigma of mental health issues among young college students, and analysed the effectiveness of Indian therapeutic interventions, Yoga and Rajyoga meditation, in improving the brain dynamics of Yoga college students. This study is the first of its kind that can provide the wavelet decomposition-based EEG features and the cognitive PEBL task features as neurophysiological markers.
Methods: Electroencephalographic signals and scores from PEBL battery tasks were recorded during performing PEBL tasks before and after eight weeks of intervention.
Results: The post-intervention meditators group demonstrated a substantial improvement in the average scores and memory span in the cognition battery tasks. Additionally, theta, alpha, and beta band powers were higher for post-meditators in frontal, temporal, and parietal regions during CORSI and SIMON tasks.
Conclusion: The findings suggest that the combination of Yoga and Rajyoga meditation practice leads to increase in spatial attention, spatial memory, and working memory.
Design, In Silico Molecular Docking, and ADMET Prediction of Amide
Derivatives of Chalcone Nucleus as EGFR Inhibitors for the Treatment of
Cancer
Authors: Patil Shital , Randive Vrushali , Mahadik Indrani , Asgaonkar Kalyani 
Published: November 2023

Background:
Cancer is a devastating disease. Many studies have shown that the primary
causes of the aggressive and resistant types of cancer are the overexpression of receptors and growth
factors, activation of oncogenes, and the inactivation of tumour suppressor genes. One such receptor
is the epidermal growth factor receptor (EGFR), which is used as a drug target for the treatment of
cancer.

Objective:
This study aimed to develop the new chemical entities of amide derivatives of chalcone
as EGFR inhibitors using structure-activity relationship (SAR) studies, molecular docking, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) studies

Method:
New chemical entities (NCE) were designed based on literature findings. The Schrodinger
13.4 software was used for the molecular docking study. While Quickprop and Pro Tox-II online
tools were used for ADME and toxicity prediction, respectively.

Result:
In this work, all compounds were subjected to an in-silico ADMET analysis. After pharmacokinetic and toxicity profile predictions, the molecules were further analysed by molecular docking.
As a result of molecular docking, molecules AC9 and AC19 showed comparable docking scores
compared to standard Afatinib.

Conclusion:
Molecules AC9 and AC19 showed good docking scores and a promising ADMET profile. In the future, these derivatives can be further evaluated for wet lab studies and determination of
their biological activity.
Cellular Transdifferentiation: A Crucial Mechanism of Fibrosis in Systemic Sclerosis
Authors: Jimenez Sergio A. , Piera-Velazquez Sonsoles 
Published: November 2023

Abstract:Systemic Sclerosis (SSc) is a systemic autoimmune disease of unknown etiology with a highly complex pathogenesis that despite extensive investigation is not completely understood. The clinical and pathologic manifestations of the disease result from three distinct processes: 1) Severe and frequently progressive tissue fibrosis causing exaggerated and deleterious accumulation of interstitial collagens and other extracellular matrix molecules in the skin and various internal organs; 2) extensive fibroproliferative vascular lesions affecting small arteries and arterioles causing tissue ischemic alterations; and 3) cellular and humoral immunity abnormalities with the production of numerous autoantibodies, some with very high specificity for SSc. The fibrotic process in SSc is one of the main causes of disability and high mortality of the disease. Owing to its essentially universal presence and the severity of its clinical effects, the mechanisms involved in the development and progression of tissue fibrosis have been extensively investigated, however, despite intensive investigation, the precise molecular mechanisms have not been fully elucidated. Several recent studies have suggested that cellular transdifferentiation resulting in the phenotypic conversion of various cell types into activated myofibroblasts may be one important mechanism. Here, we review the potential role that cellular transdifferentiation may play in the development of severe and often progressive tissue fibrosis in SSc.
Effect of Pharmacological Methods in Accelerated Orthodontics: A Literature Review
Authors: Almalki Abdullah 
Published: November 2023

Aims:
This study aimed to perform a literature review on the effect of pharmacological methods in accelerated orthodontics and the evidence of published studies.

Materials and Methods:
A search of the reported literature till December, 2020, was conducted using “PubMed,” “Google Scholar,” and “manual search.” The MesH terms and keywords in the search criteria were “tooth movement,” “orthodontics,” “pharmacological,” and “drugs” in various combinations. The search was confined to the English language. Data extraction was done under the heading authors, country and year, study design (level of evidence), study type, and pharmacological agents. The level of evidence of included studies was in accordance with the National Health and Medical Research Council.

Results:
Five hundred forty-seven studies were retrieved from different databases, and 12 were included in this review. Out of 12 included studies, 10 were animal studies, and two were human trials. Pharmacological agents utilized for intervention were prostaglandin, followed by relaxin, vitamin D, and parathyroid hormone. The level of evidence in the human study was reported as level II, and for animal studies, level III; all the included studies recorded accelerated tooth movement. The risk of bias in the included animal studies was unclear, and the risk was low and moderate for human studies.

Conclusion:
Prostaglandin, interleukins, parathyroid hormone, and vitamin D are commonly used in published literature for accelerating tooth movement. Nonetheless, all these experimented drugs have few or other unsolicited adverse effects. Further studies with long-term follow-ups are recommended to support the utilization of pharmacological methods in accelerated orthodontic movements.
Penerapan Kawat Litz Pada Motor BLDC Untuk Peningkatan Gaya Dorong Per Daya
Authors: Firdausi Muhammad Syauqi , Supardi Tri Wahyu , Hujja Roghib Muhammad 
Published: November 2023

Copper loss can cause a decrease in performance in BLDC motors, so efforts will be made to reduce copper loss by using Litz wire. Additionally, there have been studies that simulate the performance of Litz wire, but they have not been directly applied, especially to propeller thrust. The objective of this research is to implement Litz wire in a BLDC motor and analyze its performance for an increase in propeller thrust per power. The BLDC motor is wound with single wire and Litz wire. The analysis conducted compares the resistance, copper loss, thrust force, and thrust-to-power ratio of the single wire and Litz wire with the same wire cross-sectional area. The BLDC motor is equipped with a propeller to measure the thrust force. The average resistance of the single wire is 0.43 Ohms, while the Litz wire is 0.38 Ohms. The copper loss of the Litz wire is 7% lower than a single wire. The Litz wire exhibits a 3% improvement in thrust force compared to the single wire in the testing. The thrust-to-power ratio of the Litz wire is also 3% better during the testing.
Analisis Kebutuhan LKPD Elektronik Berbasis Problem Based Learning Pada Materi Keanekaragaman Hayati Kelas X SMA/MA Sebagai Suplemen Pembelajaran Biologi
Authors: Indriani Sisi , Yogica Relsas 
Published: November 2023

This study aims to determine tehe need for biology learning in the form of electronic student worksheets based on problem based learning on biodiversity material for class X at MAN 2 Padang. This type of research is descriptive quantitative. The method used to collect data is through distributing questionnaires to class X students and distributing questionnaires to biology teachers. The results of the analysis of student questinnaires and teacher questionnaires indicate that the material on biodiversity is one of the materials considered constrained in learning. The learning resources provided by the teacher are in the form of biology textbooks, power points, LKPD, etc., but their learning outcomes tend to be constant, so it is necessary to have a variety of learning media. One solution to this problem is to develop learning media in the form of valid and practical electronic student worksheets.
abstrak. Penelitian ini bertujuan untuk mengetahui kebutuhan media pembelajaran biologi berupa lembar kerja peserta didik elektronik berbasis problem based learning pada materi keanekaragaman hayati untuk kelas X di MAN 2 Padang. Jenis penelitian ini adalah deskriptif kuantitatif. Metode yang digunakan untuk mengumpulkan data yaitu melalui penyebaran angket kepada peserta didik kelas X dan penyebaran angket kepada guru biologi. Hasil analisis angket peserta didik dan angket guru menunjukkan bahwa materi keanekaragaman hayati merupakan salah satu materi yang dianggap terkendala dalam pembelajaran. Sumber belajaar yang diberikan guru berupa buku paket biologi, power point, LKPD, dll, namun hasil belajar mereka cenderung tetap, sehingga sangat diperlukan adanya variasi media pembelajaran. Salah satu solusi dari permasalahan ini adalah dengan mengembangkan media pembelajaran berupa lembar kerja peserta didik elektronik yang valid dan praktis.
Kata kunci: analisis kebutuhan, LKPD elektronik, problem based learning, keanekaragaman hayati.
Pengembangan Buku Ajar Desain Pembelajaran Biologi Berbasis Socio-Eco-Techno-Preneurship
Authors: Hakim Nasrul , Hayati Dwi Kurnia , Saputri Umi 
Published: November 2023

This study aims to develop a socio-eco-techno-preneurship-based Biology Learning Design textbook. The development model used in this research is a 4D development model which includes Define, Design, Develop, and Disseminate. The results of the design expert validation obtained a score of 89% included in the very good category. The results of material expert validation obtained a score of 92% of and included in the very good category. The validation of linguists obtained a score of 90% and included in the very good category. The results of the response from the Tadris biology lecturer obtained a score of 85% and included in the very good category. The results of the limited trial to biology tadris students obtained a score of 87.25% and included in the very good category. Based on the research data, it can be concluded that the textbook product developed is suitable for use in the learning process.
Key words: Learning Design, Texbook, entrepneurship

ABSTRAK
Penelitian ini bertujuan untuk mengembangkan buku ajar Desain Pembelajaran Biologi berbasis socio-eco-techno-preneurship. Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan 4 D yang meliputi Define, Design, Develop, dan Disseminate. Hasil validasi ahli materi diperoleh skor 90% sebesar dan termasuk dalam kategori sangat baik . Hasil validasi ahli desain diperoleh skor 89% termasuk dalam kategori sangat baik. Validasi ahli bahasa diperoleh skor 92% dan termasuk kategori sangat baik. Hasil respon dosen Tadris biologi diperoleh skor 87,5% dan termasuk kategori sangat baik. Hasil ujicoba terbatas kepada mahasiswa tadris biologi diperoleh skor 90% dan termasuk kategori sangat baik. Berdsarkan data hasil penelitian dapat disimpulkan produk buku ajar yang dikembangkan layak digunakan dalam proses pembelajaran.
Kata kunci: Desain Pembelajaran, Buku Ajar, entrepreneurship
Successful use of intravenous and oral levetiracetam in a goat to control refractory seizures secondary to suspected polioencephalomalacia
Authors: Stapley Emma D. , Breuer Ryan M. , Burton Alexandra J. 
Published: November 2023

Abstract

OBJECTIVE
To assess the clinical efficacy and plasma concentrations of levetiracetam in a goat with seizures.

ANIMAL
A 5-month-old doeling.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES
The goat was referred because of progressive anorexia and lethargy over 3 days. Clinical signs consisted of weakness, obtundation, opisthotonos, anisocoria, and cortical blindness. Initial evaluation was most consistent with polioencephalomalacia.

TREATMENT AND OUTCOME
Neurologic improvement occurred within 4 hours of thiamine administration, with appetite returning over 12 hours. On day 3 of hospitalization, the goat suffered acute onset repetitive seizures that were incompletely responsive to standard interventions over 3 hours. Administration of IV levetiracetam (60 mg/kg) produced resolution of seizure activity within 20 minutes. Levetiracetam was continued twice daily IV, then PO after day 6. Plasma concentrations were above or within therapeutic ranges (5 to 45 μg/mL) as previously established for other species, following both IV and PO levetiracetam. Oral administration (60 mg/kg, PO, q 12 h) resulted in plasma levetiracetam concentrations of 48.1 μg/mL 2 hours after a dose and 23.4 μg/mL 2 hours prior to the next dose.

CLINICAL RELEVANCE
Levetiracetam is a newer anticonvulsant commonly used in humans and small animals due to its efficacy, cost, and wide safety margin. Its use has not previously been reported in domestic small ruminants. In this case, levetiracetam showed excellent clinical efficacy in the face of refractory seizures, with no apparent side effects. Plasma concentrations during oral administration were at the high end of the therapeutic range, indicating absorption in a nonmonogastric species. Further studies are warranted to determine optimal dosing in small ruminants.
Magnetic resonance imaging in assessing the staging of intracerebral hemorrhages in children
Authors: Mazaev A. P. , Molodtsov M. S. , Shchelykalina S. P. 
Published: November 2023

The purpose of the study was to evaluate the possibilities of MRI in determining the stage of hemorrhagic stroke (HS) depending on structural and perifocal changes in children.Materials and methods. The study included 46 patients (including 19 boys and 27 girls) aged from the 29th day of life to 18 years, with a clinical picture of cerebrovascular accident and the presence of HS in the brain substance (BS) during an MRI study. For statistical analysis, patients were divided into two groups: group 1 – patients examined in the first 48 hours from the onset of neurological symptoms (21 people), group 2 – after 48 hours (26 people). Comparison in two groups was carried out according to MR signs: the presence of perifocal cytotoxic edema, the presence of perifocal hemorrhagic impregnation, the presence of a cytoplasmic rim. Intergroup comparisons on a qualitative basis were carried out using Fisher's exact test.Results. As a result of the study, differential diagnostic criteria for the stages of HS in children were determined by analyzing the MRI semiotics of hematoma in combination with the symptom complex of perifocal changes (CPC) in the form of perifocal cytotoxic edema, perifocal hemorrhagic impregnation and cytoplasmic rim. Statistically significant differences in the frequency of occurrence of signs of perifocal cytotoxic edema and perifocal hemorrhagic impregnation in the groups were found. The presence of perifocal cytotoxic edema was statistically significant (p = 0.027) more common in group 1 (47% (n = 10), 95% CI 26–69) than in group 2 (16% (n = 4), 95% CI 5–36). The presence of perifocal hemorrhagic soaking was statistically significantly (p = 0.003) more common in group 1 (81% (n = 17), 95% CI 57–93) than in group 2 (36% (n = 9), 95% CI 18–57). In addition, a statistically significant (p = 0.005) difference was found in the incidence of CPC, which was observed in group 1 (28% (n = 6), CI 12–52) and was not observed in group 2 (0%, (n = 0), 95% CI 0–17).Conclusions. The use of T2, T1, FLAIR, SWI and DWI modes (b = 1000) in combination with ADC in the protocol of MRI examination of children is mandatory, and only a comparison of the characteristics of the MR signal from a hematoma in combination with an analysis of perifocal changes allows us to differentiate the stage of hemorrhage. HS in the acute and early subacute stages has a similar MRI semiotics, therefore, it is necessary to assess the complex of perifocal changes, which allows to differentiate these stages, as it is determined in patients examined in the first 48 hours (p < 0.05) and is not observed after two days. SWI analysis makes it possible to differentiate the late subacute stage of hematoma from chronic due to different characteristics of the MR signal, and also allows you to establish the presence of perifocal hemorrhagic impregnation, which contributes to the differential diagnosis of hemorrhage in the early stages of the pathological process.
Design Optimization of Lambda-Wing Planform and Vortex Generators for Longitudinal Instability Alleviation
Authors: Lee Seonguk , Kim Chongam 
Published: November 2023

This paper focuses on optimizing the planform and vortex generators (VGs) to improve longitudinal stability of the lambda-wing aircraft by alleviating pitchup. The optimizations are performed in two stages using a Reynolds-averaged Navier–Stokes (RANS) solver that can accurately capture the vortical flow structure, affecting the pitchup. First, the planform configuration is optimized to minimize the rise in the pitching moment while maintaining aerodynamic and stealth performances. The designed planform delays the pitchup by 4 deg and increases the usable lift by 31% due to the leading-edge vortex (LEV) flow over the outboard wing. Second, the VGs are installed and optimized to reduce the sudden increase in the pitching moment at high angles of attack. The designed VGs partially eliminate the separated flow and recover the LEV on the outboard wing, suppressing the radical change in the pitching moment by 75%. Some quantitative difference in aerodynamic coefficients is observed in unsteady RANS computations, but the vortical flow unsteadiness minimally affects the flow structure, and the stability improvement remains over 80%. Overall, the generation and sustainability of the LEV are critical aerodynamic factors to secure longitudinal stability in designing the lambda-wing aircraft.
SPORTING EVENTS IN THE MEDIA IN THE CONTEXT OF THE COLD WAR (by the example of coverage of the Olympic Games in Moscow 1980 and in Los Angeles 1984)
Authors: Сергиенко А.Э. 
Published: November 2023

В статье проанализировано освещение в СМИ Олимпийских игр в Москве 1980 г. и в Лос-Анджелесе 1984 г. в качестве инструмента пропагандистского воздействия на аудиторию в контексте противостояния политических систем СССР и стран Запада. Автор уделяет особое внимание использованию бойкота соревнований.
The article analyzes media coverage of the Olympic Games in Moscow in 1980 and in Los Angeles in 1984 as a tool of propaganda influence on the audience in the context of confrontation between the political systems of the USSR and Western countries. The author pays special attention to the use of competition boycott.
GIÁ TRỊ VĂN HÓA BIỂN TRUYỀN THỐNG CỦA CƯ DÂN VÙNG DUYÊN HẢI CÁC TỈNH QUẢNG BÌNH, QUẢNG TRỊ VÀ THỪA THIÊN HUẾ
Authors: Nguyễn Thị Hoài Phúc 
Published: November 2023

Vùng ven biển Trung Trung bộ trong nghiên cứu này chỉ giới hạn không gian các tỉnh Quảng Bình, Quảng Trị và Thừa Thiên Huế; nơi đây có một cộng đồng dân cư đông đảo sống dọc theo đường bờ biển dài 311,04 km. Cộng đồng dân cư ven biển đó trong quá trình lịch sử lao động, sáng tạo và giữ gìn biên cương biển đảo của đất nước đã tạo dựng cho mình nhiều giá trị đặc trưng không chỉ thể hiện sắc thái văn hóa vùng miền mà còn là nguồn lực sức mạnh cho công cuộc khai thác biển, bảo vệ chủ quyền vùng biển đảo thiêng liêng của nước ta. Bài viết này, trên cơ sở kết quả nghiên cứu tài liệu, nghiên cứu thực địa tại vùng dân cư ven biển ở các tỉnh Quảng Bình, Quảng Trị và Thừa Thiên Huế đề cập đến lịch sử hình thành và phát triển văn hóa biển và các giá trị văn hóa đặc trưng của cu dân vùng ven biển Trung Trung bộ.
THỰC TRẠNG HOẠT ĐỘNG TƯ VẤN TÂM LÝ CHO HỌC SINH Ở CÁC TRƯỜNG TRUNG HỌC PHỔ THÔNG HUYỆN PHÚ VANG, TỈNH THỪA THIÊN HUẾ
Authors: Nguyen Van Bac , Phu Nguyen Ba , Van Khuyen Le , Van Hoa Doan 
Published: November 2023

Tóm tắt: Nghiên cứu này được thực hiện nhằm đánh giá thực trạng công tác tư vấn tâm lý cho học sinh ở các trường trung học phổ thông. Mẫu nghiên cứu gồm 85 cán bộ quản lý, giáo viên và 221 học sinh từ lớp 10 đến lớp 12 của 3 trường THPT trên địa bàn huyện Phú Vang, tỉnh Thừa Thiên Huế gồm: THPT Vinh Xuân, Hà Trung và Nguyễn Sinh Cung. Bảng hỏi gồm nhận thức về tầm quan trọng và ý nghĩa của tư vấn tâm lý cho học sinh, những khó khăn tâm lý và mức độ thực hiện tư vấn tâm lý ở học sinh, các hình thức và phương pháp tư vấn tâm lý cho học sinh, các yếu tố tác động tới tư vân tâm lý cho học sinh. Kết quả nghiên cứu cho thấy, cán bộ quản lý, giáo viên và học sinh đều nhận thức tầm quan trọng, ý nghĩa của công tác tư vần tâm lý cho học sinh trong nhà trường. Học sinh gặp khó khăn tâm lý ở nhiều mặt và nhiều mức độ khác nhau dó đó mức độ tư vấn tâm lý của học sinh cũng rất đa dạng. Công tác tư vấn tâm lý được thực hiện nhiều hình thức, phương pháp nhằm đáp ứng mong muốn ở học sinh. Có nhiều yếu tố tác động tới công tác tư vấn tâm lý cho học sinh trong nhà trường, trong đó kiến thức kỹ năng có tác động mạnh. Trên cơ sở đánh giá thực trạng, bài viết đề xuất biện pháp nhằm nâng cao hiệu quả công tác tư vấn tâm lý học đường cho học sinh ở các trường trung học phổ thông trên địa bàn huyện Phú Lộc, tỉnh TT Huế
NGHIÊN CỨU THỰC TRẠNG VÀ ĐỀ XUẤT GIẢI PHÁP NÂNG CAO HIỆU QUẢ TỔ CHỨC HOẠT ĐỘNG THỂ DỤC, THỂ THAO NGOẠI KHÓA CHO SINH VIÊN ĐẠI HỌC HUẾ TRONG BỐI CẢNH HIỆN NAY
Authors: Lê Cát Nguyên 
Published: November 2023

Mục tiêu của nghiên cứu này là khảo sát thực trạng để làm cơ sở đề xuất giải pháp nâng cao hiệu quả tổ chức hoạt động thể dục, thể thao ngoại khóa (TDTTNK) cho sinh viên (SV) Đại học Huế trong bối cảnh hiện nay. Số liệu nghiên cứu được thu thập từ kết quả khảo sát 40 cán bộ (CB), giảng viên (GV) và 459 SV thuộc Đại học Huế. Số liệu được xử lý bằng phần mềm thống kê SPSS 22.0. Từ kết quả điều tra thực trạng, kết hợp với sử dụng phương pháp thảo luận nhóm trọng tâm và phương pháp phân tích ma trận SWOT, chúng tôi đề xuất một số giải pháp để nâng cao hiệu quả tổ chức hoạt động TDTTNK cho SV Đại học Huế gồm: Tăng cường công tác truyền thông, vận động SV tham gia hoạt động TDTTNK thường xuyên; Chú trọng đào tạo, bồi dưỡng, có kế hoạch tuyển dụng hợp lí để tăng cường nguồn nhân lực tổ chức hoạt động TDT NK; Đẩy mạnh công tác xã hội hóa thể dục, thể thao (TDTT) để tăng cường cơ sở vật chất (CSVC) phục vụ hoạt động TDTT tại Đại học Huế; Đa dạng hóa nội dung, hình thức tổ chức hoạt động TDTTNK cho SV; Xây dựng chế độ chính sách phù hợp cho CB, GV, SV khi tham gia hoạt động TDTTNK.