bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between‐year and spatial variation in body condition across the breeding cycle in a pelagic seabird, the Red‐billed Tropicbird
Authors: Beard Annalea , Thomas Robert J. , Medeiros Mirra Renata , Clingham Elizabeth , Henry Leeann , Saldanha Sarah , González‐Solís Jacob , Hailer Frank 
Published: December 2023

AbstractBody condition in pelagic seabirds impacts key fitness‐related traits such as reproductive performance and breeding frequency. Regulation of body condition can be especially important for species with long incubation periods and long individual incubation shifts between foraging trips. Here, we show that body condition of adult Red‐billed Tropicbirds (Phaethon aethereus) at St Helena Island, South Atlantic Ocean, exhibited considerable variation between years (2013–2017) and between different stages of the breeding cycle. Females took the first incubation shift following egg laying, after which males and females alternated incubation shifts of varying length, ranging from <1 to 12 days. Body condition declined in both sexes during an incubation shift by an average of 22 g (2.83% of starting mass) per day and over the incubation period; mass loss was significantly greater during longer incubation shifts, later within a shift and later in the total incubation period. There was also significant differences in incubation behaviour and body condition between years; in 2015, coinciding with a moderate coastal warming event along the Angolan‐Namibian coastlines, adults on average undertook longer incubation shifts than in other years and had lower body condition. This suggests that substantial between‐year prey fluctuations in the Angola Benguela upwelling system may influence prey availability, in turn affecting incubation behaviour and regulation of body condition. Adults rearing chicks showed a significant reduction in body condition when chicks showed the fastest rate of growth. Chick growth rates during 2017 from two localities in the Atlantic Ocean: an oceanic (St Helena) versus neritic (Cabo Verde) population were similar, but chicks from St Helena were overall heavier and larger at fledging. Results from this multi‐year study highlight that flexibility and adaptability in body condition regulation will be important for populations of threatened species to optimise resources as global climate change increasingly influences prey availability.
A common polar dye additive as corrosion inhibitor and leveling agent for stable aqueous zinc‐ion batteries
Authors: Wang Hao , Hu Chao , Yang Zefang , Wu Tingqing , Li Yihu , Zhang Qi , Tang Yougen , Wang Haiyan 
Published: December 2023

AbstractThe industrial application of zinc‐ion batteries is restricted by irrepressible dendrite growth and side reactions that resulted from the surface heterogeneity of the commercial zinc electrode and the thermodynamic spontaneous corrosion in a weakly acidic aqueous electrolyte. Herein, a common polar dye, Procion Red MX‐5b, with high polarity and asymmetric charge distribution is introduced into the zinc sulfate electrolyte, which can not only reconstruct the solvation configuration of Zn2+ and strengthen hydrogen bonding to reduce the reactivity of free H2O but also homogenize interfacial electric field by its preferentially absorption on the zinc surface. The symmetric cell can cycle with a lower voltage hysteresis (78.4 mV) for 1120 times at 5 mA cm−2 and Zn//NaV3O8·1.5H2O full cell can be cycled over 1000 times with high capacity (average 170 mAh g−1) at 4 A g−1 in the compound electrolyte. This study provides a new perspective for additive engineering strategies of aqueous zinc‐ion batteries.
Magnetic r‐graphene oxide‐doped tin‐lanthanum intercalated thiosulfate layered double hydroxide as a new nanocomposite sorbent for the extraction of tetracycline and oxytetracycline residues in pharmaceutical wastewater
Authors: Malmir Maryam , Shemirani Farzaneh 
Published: December 2023

AbstractA new analytical method combining magnetic micro‐solid phase extraction (μ‐SPE) in tandem with high‐performance liquid chromatography‐ultraviolet (HPLC‐UV) analysis was developed and used for the simultaneous extraction/preconcentration of tetracycline (TC) and oxytetracycline (OTC) residues in drug manufacturing effluents. The μ‐SPE conducted by the introduction of iron oxide reduced‐graphene oxide (MrGO) doped tin‐lanthanium intercalated with thiosulfate ions to produce magnetic LDH (MrGO/Sn‐La‐S). The adsorbent was synthesized and characterized using x‐ray diffraction, Fourier transform infrared, scanning electron microscopy, energy‐dispersive x‐ray, elemental mapping, transmission electron microscopy, x‐ray photoelectron spectroscopy, and value stream mapping techniques. The effective parameters, including the extraction and desorption steps, were investigated and optimized. Under optimized conditions, the limits of detection (LOD) for TC and OTC were obtained as 5.42 and 3.31 μg.L−1, respectively, while the linearity was in the range of 10.0–500.0 μg.L−1 for both antibiotics with satisfactory determination coefficients (R2) of 0.9811 and 0.9846 for TC and OTC, respectively. The recovery percentages for the analytes in real samples were achieved in the ranges of 89.2%–101.6% and 91.0%–101.3% for TC and OTC antibiotics, respectively. All these features proved the potential of the developed method and adsorbent for real world applications.
Anthocyanins from Lycium ruthenicum Murray attenuates high‐fat diet‐induced hypercholesterolemia in ApoE−/− mice are related to the modulation of gut microbiota and the ratio of conjugated to unconjugated bile acids in fecal bile acid profile
Authors: Zhang Meng , Li Hui , Tan Tingting , Lu Lu , Mi Jia , Rehman Abdul , Yan Yamei , Ran Linwu 
Published: December 2023

AbstractPrevious findings showed that anthocyanins from Lycium ruthenicum Murray (ACN) reduced HFD‐induced hypercholesterolemia by regulating gut microbiota, but the mechanism has not been fully understood. The objective of this research was to know whether the cholesterol‐lowering impact of ACN in HFD‐induced ApoE−/− mice is related to the gut microbiota‐bile acid (BA) metabolism. Twenty‐four male ApoE−/− mice were divided into three groups: the Control group, the HFD group, and the HFD + ACN group. Here, we showed that ACN intervention reduced HFD‐induced body weight serum concentrations of TC and LDL‐C and ameliorated lipid accumulation in the liver and adipose tissues. Besides, ACN altered gut microbiota composition in HFD‐fed ApoE−/− mice. Moreover, UHPLC–MS/MS analysis revealed that ACN intervention significantly increased the ratio of conjugated to unconjugated BAs in feces induced by HFD, attributed to the increase in conjugated BAs and decrease in unconjugated BAs. Finally, the correlation analysis indicated that the above changes in fecal BA profile were linked with an increase in Bifidobacterium, Allobaculum and a decrease in Ileibacterium, Helicobacter, Rikenellaceae_RC9_gut_group, Blautia, Odoribacter, and Colidextribacter. In summary, ACN could alleviate HFD‐induced hypercholesterolemia in ApoE−/− mice, which was associated with the improvement of gut microbiota and modulation of fecal BA profile.
The use of practice assignments in cognitive processing therapy to promote cognitive and emotional change: A case study
Authors: Wachen Jennifer Schuster 
Published: December 2023

AbstractCognitive processing therapy (CPT) is a first‐line treatment for posttraumatic stress disorder (PTSD). The primary goals of CPT are to identify and challenge dysfunctional cognitions resulting from the trauma to promote a more balanced set of beliefs and reduce manufactured emotions; encouraging expression of natural emotions further promotes symptom improvement. Between‐session assignments (homework) are an integral part of learning and practicing the skills developed during CPT, and these assignments are theorized to reinforce the proposed mechanisms of symptom change. This article begins with a brief description of the theoretical foundations of CPT and an overview of the session content of the CPT protocol, followed by a case study illustrating the use of CPT with the written account (CPT + A) with a survivor of childhood sexual assault. Although the client demonstrated some avoidance, her successful completion of practice assignments throughout treatment allowed her to identify and examine thoughts contributing to feelings of guilt and self‐blame as well as negative beliefs about the world. She was able to reduce her assimilated and overaccommodated stuck points to form a more balanced view of the trauma, and also process her natural emotions, resulting in a significant reduction of PTSD symptoms. The role of homework at each session and how the assignments addressed the proposed mechanisms of change in CPT are discussed, and recommendations to increase clients’ engagement in practice assignments in CPT are provided.
Cadherin‐5 facilitated the differentiation of human induced pluripotent stem cells into sinoatrial node‐like pacemaker cells by regulating β‐catenin
Authors: Zhang Wei , Wang Fengyuan , Yin Lin , Tang Yanhong , Wang Xi , Huang Congxin 
Published: December 2023

AbstractOur study was conducted to investigate whether cadherin‐5 (CDH5), a vascular endothelial cell adhesion glycoprotein, could facilitate the differentiation of human induced pluripotent stem cells (hiPSCs) into sinoatrial node‐like pacemaker cells (SANLPCs), following previous findings of silk‐fibroin hydrogel‐induced direct conversion of quiescent cardiomyocytes into pacemaker cells in rats through the activation of CDH5. In this study, the differentiating hiPSCs were treated with CDH5 (40 ng/mL) between Day 5 and 7 during cardiomyocytes differentiation. The findings in the present study demonstrated that CDH5 stimulated the expression of pacemaker‐specific markers while suppressing markers associated with working cardiomyocytes, resulting in an increased proportion of SANLPCs among hiPSCs‐derived cardiomyocytes (hiPSC‐CMs) population. Moreover, CDH5 induced typical electrophysiological characteristics resembling cardiac pacemaker cells in hiPSC‐CMs. Further mechanistic investigations revealed that the enriched differentiation of hiPSCs into SANLPCs induced by CDH5 was partially reversed by iCRT14, an inhibitor of β‐catenin. Therefore, based on the aforementioned findings, it could be inferred that the regulation of β‐catenin by CDH5 played a crucial role in promoting the enriched differentiation of hiPSCs into SANLPCs, which presents a novel avenue for the construction of biological pacemakers in forthcoming research.
Up‐regulation of TNF‐alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma
Authors: de Castro Letícia Rodrigues , de Oliveira Lucas Dias , Milan Thaís Moré , Eskenazi Ana Patrícia Espaladori , Bighetti‐Trevisan Rayana Longo , de Almeida Otávio Guilherme Gonçalves , Amorim Marcio Luis Munhoz , Squarize Cristiane Helena , Castilho Rogerio Moraes , de Almeida Luciana Oliveira 
Published: December 2023

AbstractTumor resistance remains an obstacle to successfully treating oral squamous cell carcinoma (OSCC). Cisplatin is widely used as a cytotoxic drug to treat solid tumors, including advanced OSCC, but with low efficacy due to chemoresistance. Therefore, identifying the pathways that contribute to chemoresistance may show new possibilities for improving the treatment. This work explored the role of the tumor necrosis factor‐alpha (TNF‐alpha)/NFkB signaling in driving the cisplatin resistance of OSCC and its potential as a pharmacological target to overcome chemoresistance. Differential accessibility analysis demonstrated the enrichment of opened chromatin regions in members of the TNF‐alpha/NFkB signaling pathway, and RNA‐Seq confirmed the upregulation of TNF‐alpha/NFkB signaling in cisplatin‐resistant cell lines. NFkB was accumulated in cisplatin‐resistant cell lines and in cancer stem cells (CSC), and the administration of TNF‐alpha increased the CSC, suggesting that TNF‐alpha/NFkB signaling is involved in the accumulation of CSC. TNF‐alpha stimulation also increased the histone deacetylases HDAC1 and SIRT1. Cisplatin‐resistant cell lines were sensitive to the pharmacological inhibition of NFkB, and low doses of the NFkB inhibitors, CBL0137, and emetine, efficiently reduced the CSC and the levels of SIRT1, increasing histone acetylation. The NFkB inhibitors decreased stemness potential, clonogenicity, migration, and invasion of cisplatin‐resistant cell lines. The administration of the emetine significantly reduced the tumor growth of cisplatin‐resistant xenograft models, decreasing NFkB and SIRT1, increasing histone acetylation, and decreasing CSC. TNF‐alpha/NFkB/SIRT1 signaling regulates the epigenetic machinery by modulating histone acetylation, CSC, and aggressiveness of cisplatin‐resistant OSCC and the NFkB inhibition is a potential strategy to treat chemoresistant OSCC.
DNA demethylation of promoter region orchestrates SPI‐1‐induced ADAMTS‐5 expression in articular cartilage of osteoarthritis mice
Authors: Liu Zhixin , Lu Tongxin , Ma Liang , Zhang Yuankai , Li Deqiang 
Published: December 2023

AbstractOsteoarthritis (OA) is one of the most prevalent joint diseases in aged people and characterized by articular cartilage degeneration, synovial inflammation, and abnormal bone remodeling. Recent advances in OA research have clearly shown that OA development is associated with aberrant DNA methylation status of many OA‐related genes. As one of most important cartilage degrading proteases in OA, a disintegrin and metalloproteinase with thrombospondin motifs subtype 5 (ADAMTS‐5) is activated to mediate cartilage degradation in human OA and experimental murine OA models. The pathological factors and signaling pathways mediating ADAMTS‐5 activation during OA development are not well defined and have been a focus of intense research. ADAMTS‐5 promoter is featured by CpG islands. So far there have been no reports concerning the DNA methylation status in ADAMTS‐5 promoter during OA development. In this study, we sought to investigate DNA methylation status in ADAMTS‐5 promoter, the role of DNA methylation in ADAMTS‐5 activation in OA, and the underlying mechanisms. The potential for anti‐OA intervention therapy which is based on modulating DNA methylation is also explored. Our results showed that DNA methyltransferases 1 (Dnmt1) downregulation‐associated ADAMTS‐5 promoter demethylation played an important role in ADAMTS‐5 activation in OA, which facilitated SPI‐1 binding on ADAMTS‐5 promoter to activate ADAMTS‐5 expression. More importantly, OA pathological phenotype of mice was alleviated in response to Dnmt1‐induced DNA methylation of ADAMTS‐5 promoter. Our study will benefit not only for deeper insights into the functional role and regulation mechanisms of ADAMTS‐5 in OA, but also for the discovery of disease‐modifying OA drugs on the basis of ADAMTS‐5 via modulating DNA methylation status.
Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: Update 2023
Authors: von Haehling Stephan , Coats Andrew J.S. , Anker Stefan D. 
Published: December 2023

AbstractThe Journal of Cachexia, Sarcopenia and Muscle (JCSM) aims to publish articles with relevance to wasting disorders and illnesses of the muscle in the broadest sense. In order to avoid publication of inappropriate articles and to avoid protracted disputes, the Editors have established ethical guidelines that detail a number of regulations to be fulfilled prior to submission to the journal. This article updates the principles of ethical authorship and publishing in JCSM and its daughter journal JCSM Rapid Communication. We require the corresponding author, on behalf of all co‐authors, to certify adherence to the following principles:

All authors listed on a manuscript considered for publication have approved its submission and (if accepted) approve publication in the journal;
Each named author has made a material and independent contribution to the work submitted for publication.
No person who has a right to be recognized as author has been omitted from the list of authors on the submitted manuscript;
The submitted work is original and is neither under consideration elsewhere nor that it has been published previously in whole or in part other than in abstract form;
All authors certify that the submitted work is original and does not contain excessive overlap with prior or contemporaneous publication elsewhere, and where the publication reports on cohorts, trials, or data that have been reported on before the facts need to be acknowledged and these other publications must be referenced;
All original research work has been approved by the relevant bodies such as institutional review boards or ethics committees;
All relevant conflicts of interest, financial or otherwise, that may affect the authors' ability to present data objectively, and relevant sources of funding of the research in question have been duly declared in the manuscript;
All authors certify that they will submit the original source data to the editorial office upon request;
Authors who have used artificial intelligence, language models, machine learning, or similar technologies need to provide a written statement – as part of the manuscript – that details the use of the respective technology; none of the aforementioned technologies can be listed as an author;
The manuscript in its published form will be maintained on the servers of the journal as a valid publication only as long as all statements in these guidelines remain true.
If any of the aforementioned statements ceases to be true, the authors have a duty to notify as soon as possible the Editor‐in‐Chief of the journal, so that the available information regarding the published article can be updated and/or the manuscript can be withdrawn.
Symphyseal morphology and jaw muscle recruitment levels during mastication in musteloid carnivorans
Authors: Davis Jillian Summer , Montuelle Stephane J. , Williams Susan H. 
Published: December 2023

AbstractIn studies of mammalian mastication, a possible relationship has been proposed between bilateral recruitment of jaw adductor muscle force during unilateral chewing and the degree of fusion of the mandibular symphysis. Specifically, species that have unfused, mobile mandibular symphyses tend to utilize lower levels of jaw adductor force on the balancing (nonchewing) than the working (chewing) side of the head, when compared to related species with fused symphyses. Here, we compare jaw adductor recruitment levels in two species of musteloid carnivoran: the carnivorous ferret (unfused symphysis), and the frugivorous kinkajou (fused symphysis). During forceful chewing, we observe that ferrets recruit far more working‐side muscle force than kinkajous, regardless of food toughness and that high working‐to‐balancing side ratios are the result of increased working‐side force, often coupled with reduced balancing‐side force. We propose that in carnivorans, high working‐to‐balancing side force ratios coupled with an unfused mandibular symphysis are necessary to rotate the hemimandible for precise unilateral occlusion of the carnassial teeth and to sustain laterally oriented force on the jaw to engage the carnassial teeth during shearing of tough foods. In contrast, the kinkajou's flattened cheekteeth permit less precise occlusion and require medially‐oriented forces for grinding, thus, a fused symphysis is mechanically beneficial.
Pan‐pox‐specific T‐cell responses in HIV‐1‐infected individuals after JYNNEOS vaccination
Authors: Sisteré‐Oró Marta , Du Juan , Wortmann Diana D. J. , Filippi Marina D. , Cañas‐Ruano Esperanza , Arrieta‐Aldea Itziar , Marcos‐Blanco Agustín , Castells Xavier , Grau Santiago , García‐Giralt Natalia , Perez‐Zsolt Daniel , Boreika Rytis , Izquierdo‐Useros Nuria , Güerri‐Fernandez Robert , Meyerhans Andreas 
Published: December 2023

AbstractPeople living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan‐pox‐specific T‐cell responses in a cohort of HIV‐1‐infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose‐sparing i.d. vaccination was superior to s.c. vaccination and promoted T‐cell polyfunctionality, and the expression of the gut‐homing marker α4β7 integrin on lymphocytes. HIV‐1‐infected individuals with CD4 T‐cell counts ≤500/mm3 blood required at least a booster vaccination to exhibit efficient virus‐specific T‐cell responses. The magnitude of the Th1 response after this booster directly correlated with the CD4 T‐cell count of the vaccinees. Further studies with a larger number of participants are warranted to confirm and expand our observations.
Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis
Authors: Thulin Helena , Säfholm Jesper , Lundahl Joachim , Jovic Viktor , Adner Mikael , Nilsson Caroline 
Published: December 2023

AbstractObjectivesEosinophilic esophagitis (EoE) is an immune‐mediated antigen‐triggered inflammatory disease of the esophagus. Our aim was to investigate inflammatory responses by an ex vivo biopsy provocation‐based method, stimulating biopsies with milk, wheat, and egg extracts.MethodsAn experimental study was conducted on esophageal biopsies from children who underwent esophagogastroduodenoscopy. Supernatants were collected before and after stimulation of the biopsies with food extracts and analyzed for 45 different inflammatory markers. Biopsies were also stained for histological analyzes.ResultsStudy subjects included 13 controls, 9 active EoE, and 4 EoE in remission, median age 12 years. Of the 45 markers analyzed, three had significant differences between controls and patients with active EoE, Granzyme B, (GzmB), IL‐1ra, and CXCL8 (p < .05). Levels of GzmB were higher, and levels of IL‐1ra were lower in patients with active EoE compared with controls and EoE in remission both at baseline and after food extract stimulation. CXCL8 increased in active EoE compared with controls only after stimulation. The number of histologically detected GzmB‐positive cells were significantly higher in patients with active EoE in contrast to control and EoE remission (p < .05).ConclusionsThe levels of the barrier‐damaging protease GzmB were higher in the supernatant both before and after stimulation with food extract ex vivo in patients with active EoE. GzmB was also observed histologically in biopsies from patients with active EoE. The presence of elevated serine protease GzmB in esophageal mucosa of children with active EoE suggests a role in the pathogenesis of this disorder.