bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putting measurement-based care into action: A mixed methods study of the benefits of integrating routine client feedback in coordinated specialty care programs for early psychosis
Authors: Meyer-Kalos Piper , Owens Grace , Fisher Melissa , Wininger Lionel , Williams-Wengerd Anne , Breen Kimberleigh , Abate Josephine , Currie Ariel , Olinger Nathan , Vinogradov Sophia 
Published: February 2024

Abstract

Background: Measurement-based care (MBC) is an effective tool in the delivery of evidence-based practices (EBPs). MBC utilizes feedback loops to share information and drive changes throughout a learning healthcare system. Few studies have demonstrated this practice in team-based care for people with early psychosis. This paper describes the development of a personalized feedback report derived from routine assessments that is shared with clients and clinicians as part of a MBC process.
Methods: We used a quasi pre-post comparison design with mixed methods to evaluate the implementation of a personalized feedback report at 5 early psychosis coordinated specialty care programs (CSC). We compared clients enrolled in CSC who did and did not receive a feedback report over the first 6 months of treatment. The sample included 204 clients: 146 who did not receive the feedback report and were enrolled over 2 years, and 58 who received the feedback report. A subset of 67 clients completed measures at both intake and 6-month follow-up, including 42 who received the report and 25 who did not. We compared the two groups with regard to self-reported symptoms, likelihood of completing treatment, and perception of shared decision making. . We conducted qualitative interviews with 5 clients and 5 clinicians to identify the benefits and challenges associated with the personalized feedback report.
Results: People who received a personalized feedback report reported significant improvements in shared decision-making and had greater improvements over time in their intent to attend future treatment sessions. They engaged in more sessions for Supported Employment and Education (SEE), case management, and peer support, and fewer medication visits over the first 6 months of treatment. Both groups showed significant improvement in symptoms and functioning. Results from the qualitative analysis indicated that the experience of receiving the reports was valuable and validating for both patients and clinicians.
Conclusions: A personalized feedback report was integrated into standard of care for early psychosis programs. This process may improve shared decision-making, strengthen the likelihood to stay in treatment, and increase engagement in psychosocial interventions. We posit that this process facilitates strengths-focused discussions, enhances intrinsic motivation, and strengthens the therapeutic alliance.
Mathematical Model of Non-Generated Straight Bevel Gears Based on a Four-Axis CNC Machine
Authors: shih yi-pei , Chen Guang-Yu 
Published: February 2024

Abstract

High-precision straight bevel gears (SBGs) are commonly manufactured using the generating method, which requires specialized equipment such as a dedicated or five-axis CNC machine for mass production. While the existing forming process can also be applied to produce SBGs, which offers a more cost-effective solution with a four-axis CNC machine, it results in inferior gear contact performance. This paper introduces a novel forming (non-generating) method. The goal is to enhance the gear contact performance. First, the tool profile of the pinion is computed based on the ring gear’s conjugate tooth surface. Subsequently, a sensitivity analysis on the tooth surface, considering four-axis motion coefficients, facilitates the calculation of correction amounts for tooth cutting motion. This process determines the pinion’s tooth surface, optimizing the contact performance by ensuring it contacts the ring gears precisely at a point. Ease-off and tooth contact analyses are utilized to evaluate the contact performance of the designed gear pair. Furthermore, VERICUT software is employed for cutting simulation to validate the NC machining codes. After this, a cutting experiment is conducted to verify the correctness of our mathematical model.
NAC1 Promotes Stemness and Regulates Myeloid-derived Cell Status in Triple-Negative Breast Cancer
Authors: NGULE CHRISPUS , Shi Ruyi , Ren Xingcong , Jia Hongyan , Oyelami Felix , Kim Jinhwan , Hemati Hami , Zhang Yi , Li Dong , Xiong Xiaofan , Park Younhee , Shinkle Andrew , Vanderford Nathan , Zhou Binhua , Wang Jianlong , Song Jianxun , Liu Xia , Yang Jin-Ming 
Published: February 2024

Abstract

Triple negative breast cancer (TNBC) is a particularly lethal breast cancer (BC) subtype driven by cancer stem cells (CSCs) and an immunosuppressive microenvironment. Our study reveals that nucleus accumbens associated protein 1 (NAC1), a member of the BTB/POZ gene family, plays a crucial role in TNBC by maintaining tumor stemness and influencing myeloid-derived suppressor cells (MDSCs). High NAC1 expression correlates with worse TNBC prognosis. NAC1 knockdown reduced CSC markers and tumor cell proliferation, migration, and invasion. Additionally, NAC1 affects oncogenic pathways such as the CD44-JAK1-STAT3 axis and immunosuppressive signals (TGFβ, IL-6). Intriguingly, the impact of NAC1 on tumor growth varies with the host immune status, showing diminished tumorigenicity in natural killer (NK) cell-competent mice but increased tumorigenicity in NK cell-deficient ones. This highlights the important role of the host immune system in TNBC progression. In addition, high NAC1 level in MDSCs also supports TNBC stemness. Together, this study implies NAC1 as a promising therapeutic target able to simultaneously eradicate CSCs and mitigate immune evasion.
Military medical decision-making during training of a Swedish Navy Command and Control Team: a quantitative study of workload effects
Authors: Hindorf Marie , Bäckström Denise , Jonson Carl-Oscar , Jonsson Anders , Berggren Peter 
Published: February 2024

Abstract

Introduction
: This study compares two simulation environments for training of Swedish naval Command and Control (C2) teams by using indirect measures, including workload, combat readiness, and situation awareness (SA). Simulation-based training (SBT) provides a secure avenue to practise relevant scenarios. Fidelity, denoting the degree of realism in the simulation, and workload, characterized as the equilibrium between demands and assigned tasks, are crucial factors examined in this study of low- and high-fidelity naval simulations.
Materials and methods
An experimental design with repeated measures was used with three consecutive escalating parts. The subjective, multidimensional assessment tool, NASA-TLX, was used to rate perceived workload.
Results
One dependent measure yielded significant results; the main effects on combat readiness of the ship were significant. Variations were noted between the initial and subsequent parts of the scenario, as well as between the two simulation environments. No other significant differences were identified for any of the dependent measures. Part three of the scenario was omitted due to missing data. Notably, the simulated internal battle training for onboard C2 teams in a low-fidelity setting was found to induce a level of stress comparable with that experienced in a high-fidelity setting.
Conclusion
Low-fidelity SBT can be used for cost-effective training of Swedish naval C2 teams on board. The practical implications arising from this research indicate that the utilization of a low-fidelity simulation setting can effectively support the training of other teams, such as those in medical training.
Aroma metabolism differences in Shine Muscat Grapes under summer and winter growth in Guangxi, China
Authors: Nong Yongkang , Chen Yanbei , Bai Yang , He Jianjun , Jia Haifeng , Zhou Sihong , Cheng Guo , Cao Xiongjun , Han Jiayu , Huang Xiaoyun , Bai Xianjin , Wang Bo 
Published: February 2024

Abstract
Background: Aroma components play a crucial role in grape quality formation, and diverse cultivation environments significantly impact grape aroma metabolism. This study aims to explore the differences in aroma metabolism in Shine Muscat grapes under summer and winter growth conditions in Guangxi, utilizing HS-SPME-GC-MS for aroma component measurement at different developmental stages. Omics analysis is combined to elucidate the changes in aroma components.
Results: In both summer and winter, the predominant free aroma components of grape fruits were aldehydes, terpenes, and alcohols, while bound aroma components were mainly phenols, alcohols, and terpenes. Winter fruits exhibited significantly higher total free aroma content and monomeric compound content compared to summer. Specifically, the concentration of (E)-2-hexenal was higher in winter fruits, whereas (Z)-3-hexen-1-ol showed the opposite trend. Transcriptome and qPCR results indicated that changes in C6 compounds in Shine Muscat grapes were consistent with VvLOXA, VvHPL1, and VvADH1. The differential expression of VvLOXA or VvADH1 in winter fruit may explain the higher concentration of (E)-2-hexenal or lower content of (Z)-3-hexen-1-ol in Shine Muscat grapes during winter.
Conclusions: This study reveals significant differences in the aroma metabolism of Shine Muscat grapes between summer and winter seasons, providing a foundation for regulating aroma accumulation through temperature and water control in production.
Study on the mechanism of excess void gas pressure in slopes under strong earthquake conditions
Authors: Wang Xiaoqun , Song Junlong , Xiao Lie , Huang Qiang , Wang Yupei , Feng Lin 
Published: February 2024

Abstract
Under strong earthquake conditions, excess void gas pressure is generated in slopes with cavities (without water), which accelerates tension cracking at the edges of the cavities and thus promotes slope failure. In this paper, a generalised model of a slope with cavities is proposed to explore the development of natural slope cavities, and large-scale physical shaking table tests and corresponding PFC numerical simulation tests are performed to study the formation mechanism of excess void gas pressure at depth. The following findings are obtained: (1) Sudden vibration loads of a certain intensity or sudden changes in the volume of the cavity can lead to the generation of excess void gas pressure in the cavity; (2) The deformation and damage of slopes with cavities under strong earthquake conditions can be divided into three stages: a. rupture of the top of the slope and the edges of the cavities; b. excess void gas pressure in the cavities, promoting crack propagation; and c. crack penetration, leading to overall damage of the slope; (3) Tension cracks caused by excess void gas pressure change the structure of the slope body, weaken the shear strength of the structural surfaces in the rock mass, and reduce the stability of the slope body. The above results are highly important for studying the initiation mechanism of seismically induced landslides on slopes.
Dynamics of Land Use Land Cover Change and Soil Erosion Rate in Chure Landscape of Sudurpaschim Province
Authors: Jaishi Padam Prakash , Budhathoki Sagar , Budhathoki Sanchita , Adhikari Lochana 
Published: February 2024

Abstract
Land use land cover, a dynamic process, has become a central component of current strategies in managing natural resources and monitoring environmental changes. This study adopts an integrated GIS and Remote Sensing approach to assess changes in land use, land cover (LU/LC), and soil erosion rates between 2001 and 2021. Land use maps were generated using supervised classification and the Maximum Likelihood algorithm, while RUSEL factors facilitated soil erosion mapping analysis. The findings underscore a remarkable decrease in 'agricultural land' and 'water,' accompanied by a simultaneous increase in 'settlement area,' 'forest area,' and 'bare land.' Agricultural land witnessed an annual decline of 2.5 percent, while water bodies decreased by 0.65 percent in 2021. Forest areas exhibited a 0.09 percent increment from 2001 to 2021, and settlement areas expanded at a rate of 0.41 percent annually. Notably, agricultural land reduction primarily contributed to the growth of settlement areas. Additionally, soil erosion rates rose from 3.82 (t/ha/year) in 2001 to 4.090 (t/ha/year) in 2021, indicating a correlation between land use change and soil erosion. Factors such as increased settlement, population growth, infrastructure development, riverbank cutting, and erosion were associated with the decline in agricultural land. Effective land use planning in the Churia region is imperative to address these changes. Government intervention and stakeholder cooperation are crucial to curbing forest degradation, unchecked human settlement expansion, and riverbank cutting. Furthermore, the study advocates for the intensified use of GIS and Remote Sensing technologies in monitoring and managing natural resources.
Exploring Factors Influencing Family’s Membership in Community-Based Health Insurance in the City of Gondar Peri-Urban Area, Northwest Ethiopia: A Health Belief Model Approach
Authors: Melkamu Kebede Molla , Melkamu Kebede Molla 
Published: February 2024

Abstract
Background- A research gap exists in finding practical solutions to provide affordable and accessible health insurance coverage to improve CBHI membership and sustainability to people in resource-poor settings and contribute to achieving universal health coverage (UHC) in Ethiopia. This research was initiated to analyze the role of health choice to identify significant factors based on the health belief model (HBM) by providing a theoretical framework for understanding individual health-related behavior and developing effective interventions to promote participation in health insurance programs.
Methods- Cross-sectional information was gathered from 358 families, and original facts were utilized. Descriptive and Binary logistics in the econometric model were applied for data analysis. Findings- The descriptive findings demonstrated that except for sex, religion, nuclear family largeness, and job occupation variables, other variables established a significant Consequence. The results of the logistic regression model showed that the distance of the nearest health station from the family’s home in a minute [AOR (95% CI) = .177 (.015, − .399)], being a member of the families having an official position in local government or cultural structure [AOR (95% CI) = .574 (.355, .793)], having an experience of visiting health facilities [AOR (95% CI) = .281 (.166, .396)], and perceiving the local CBHI scheme management as trustworthy [AOR (95% CI) = .404 (.233, .575)] were positively associated with family enrollment in the CBHI scheme. On the other hand, being a member of the “rotating saving and credit association” (ROSCA) [AOR (95% CI) =-.299 (-.478, − .120)] was negatively associated with the family’s enrollment in the CBHI scheme.
Conclusion- Institutional variables, trust in CBHI scheme management, and family’s experience of visiting health facilities and distance from the nearest health station were essential factors influencing enrollment, whereas “Rotating saving and credit association” (ROSCA) º negatively and statistically significantly impacted and income level was not associated with membership.
Ferritin Nanocage-Enabled Detection of Pathological Tau in Living Human Retinal Cells
Authors: Barolo Lorenzo , Gigante Ylenia , Mautone Lorenza , Ghirga Silvia , Soloperto Alessandro , Giorgi Alessandra , Ghirga Francesca , Pitea Martina , Ruocco Giancarlo , Boffi Alberto , Baiocco Paola , Angelantonio Silvia Di 
Published: February 2024

Abstract

Background Tauopathies, such as Alzheimer's disease and Frontotemporal Dementia, are debilitating neurodegenerative disorders characterized by cognitive decline. Despite extensive research, effective treatments and significant advancements in managing symptoms have been challenging to achieve. Accurate diagnosis is critical for developing effective therapeutic strategies. Hyperphosphorylated protein units and tau oligomers are recognized as reliable biomarkers for these conditions. This study introduces an innovative approach using nanotechnology to enhance the diagnostic process for tauopathies. We focus on the development and application of humanized ferritin nanocages, a novel nanoscale delivery system, designed to encapsulate and transport a tau-specific fluorophore, BT1, into human retinal cells, for the detection of neurofibrillary tangles in retinal tissue, a key marker of tauopathies. Results The delivery of BT1 into living cells was achieved through the use of humanized ferritin nanocages, a novel delivery system at the nanoscale. The humanized ferritin nanocages demonstrated efficient encapsulation and delivery of BT1 into retinal cells derived from human induced pluripotent stem cells. Our experiments demonstrated the successful colocalization of BT1 with pathological forms of tau in retinal cells derived from human induced pluripotent stem cells, highlighting the potential of this method in identifying tauopathies. Conclusions The employment of ferritin nanocages for the delivery of the BT1 probe represents an important contribution to the field of nanobiotechnology, especially in the context of neurodegenerative disease diagnostics. This method offers a promising tool for the early detection of tau tangles in retinal tissue, with significant implications for improving the diagnosis and management of tauopathies. This study exemplifies the integration of nanotechnology with biomedical science, expanding the frontiers of nanomedicine and diagnostic techniques.
Evidence of eastern rockhopper penguin feeding on a key commercial pelagic arrow squid species
Authors: Guímaro Hugo R. , Thompson David R. , Morrison Kyle W. , Fragão Joana , Matias Ricardo S. , Xavier José C. 
Published: February 2024

Abstract

Cephalopods play an important role in the Southern Ocean marine ecosystem connecting top predators and mid-trophic organisms. However, there is a lack of knowledge of the ecology of cephalopod fauna in the Pacific sector of the Southern Ocean. Stable isotope analysis (SIA) was applied to study the habitat and trophic ecology of cephalopods in the diet of eastern rockhopper penguin (Eudyptes chrysocome filholi) around Campbell Island, a New Zealand sub-Antarctic island. We assessed differences in the cephalopod component between two penguin breeding seasons, 1986-87 and 2012-13. Season 1986-87 showed a more diverse diet (7 vs. 3 species) without differences in size between the common species, Moroteuthopsis ingens and Octopus campbelli. In 2012-13, M. ingens was replaced by the squid Nototodarus sloanii in the penguin diet, suggesting changes in cephalopod biodiversity. Furthermore, δ13C and δ15N values of M. ingens revealed no significant differences between years, indicating stability in habitat and feeding ecology. However, O. campbelli displayed changes in δ13C and δ15N values, suggesting shifts in habitat and feeding habits. Environmental data indicated warmer oceanic temperatures around Campbell Island in 2012-13, possibly supporting the presence of N. sloanii. Our findings suggest changes in cephalopod biodiversity and the penguin diet between the two breeding seasons may have occurred. The presence of N. sloanii, a commercially valuable species, in later years highlights the significance of further research to explore the ecological dynamics between cephalopods and the local marine environment in this region.
Homologous-Magnetic Dual-Targeted Metal-Organic Framework to Improve the Anti-Hepatocellular Carcinoma Efficacy of PD-1 Inhibitor
Authors: Guo Hong , Li Xia , Mao Dengxuan , Wang Hong , Wei Liangyin , Qu Ding , Qin Xiaoying , Li Xiaoqi , Liu Yuping , Chen Yan 
Published: February 2024

Abstract

The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy of PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. The combined administration of tanshinone ⅡA(TSA) and astragaloside IV (As) can up-regulate the abundance and activity of TILs by normalising tumour blood vessels and reducing the levels of immunosuppressive factors respectively. For enhancing the efficacy of PD-1 antibody, a magnetic metal–organic framework (MOF) with a homologous tumour cell membrane (Hm) coating (Hm@TSA/As-MOF) is established to co-deliver TSA&As into the HCC microenvironment. Hm@TSA/As-MOF is a spherical nanoparticle and has a high total drug-loading capacity of 16.13 wt%. The Hm coating and magnetic responsiveness of Hm@TSA/As-MOF provide a homologous-magnetic dual-targeting, which enable Hm@TSA/As-MOF to counteract the interference posed by ascites tumour cells and enhance the precision of targeting solid tumours. Hm coating also enable Hm@TSA/As-MOF to evade immune clearance by macrophages. The release of TSA&As from Hm@TSA/As-MOF can be accelerated by HCC microenvironment, thereby up-regulating the abundance and activity of TILs to synergistic PD-1 antibody against HCC. This study presents a nanoplatform to improve the efficacy of PD-1 inhibitors in HCC, providing a novel approach for anti-tumour immunotherapy in clinical practice.
Molecular docking and anti-MRSA effects of bioactive compounds from Cymbopogon
Authors: Vinutha M , Manikandan A , Lakshmikanth RN , Shravani S , Divyashree B , Aishwarya K , Nagaraj MM 
Published: February 2024

Abstract
Molecular docking is an effective tool in screening bioactive compounds based on molecular mechanistic values. Efforts were taken to identify and screen plant secondary metabolites against Methicillin Resistant Staphylococcus aureus (MRSA) by means of essential oil (EO) extracted from locally available species of Cymbopogon such as C. flexuosus, C. winterianus and C. martinii. Hydro distillation of EO followed by GCMS characterization was accomplished. The library-generated compounds were docked against penicillin-binding protein 2a (PBP2a) (PDB ID: 3ZG5). We targeted PBP2a, a transpeptidase, because it produces high-level resistance to MRSA against β-lactam antibiotics through its expression. Importantly, PBP2a catalyses cell-wall crosslinking in the face of the defy by β-lactam antibiotics. A 100ns MD simulation was conducted to find the stability of the receptor-ligand complex. The anti-MRSA activity against different clinical isolates of MRSA was performed and the genetic similarity between the isolates of MRSA was analysed through RAPD technique which is quick, cost effective and more affordable technique.
Quaternion algebra on 4D superfluid quantum spacetime: the Lorentz gauge is a gate to the invisible world of dark matter and dark energy
Authors: Sbitnev Valeriy 
Published: February 2024

Abstract
Quaternion algebra is used for the description of the motion of material objects in 4D space-time. In the same quaternion basis, the energy-momentum density tensor is also written, accurate to arbitrary scalar fields. Quaternionic generating operators defined in this space being applied repeatedly to the energy-momentum density tensor lead to the gravitomagnetic equations that are parent equations for the series of physical equations ranging from the wave equations up to the quantum mechanical ones. Before finally deducing the gravitomagnetic equations, it is necessary to use the Lorentz gauge at a certain stage to cut off the arbitrary scalar fields. We declare that these superfluous scalar fields, inaccessible to direct observation, represent dark matter and dark energy.
Dark matter manifesting through the Bose-Einstein condensate looks like a time crystal composed of particle-antiparticle pairs.
We show in what way the dark matter can provide a flat profile of the orbital speed of the galaxy's arm rotations.