bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic-Assisted Surgery in Extremely Obese Patients. A Multidisciplinary Approach for a Patient with a BMI of 101.7 kg/m²
Authors: Csorba Roland , Elfrink Zeynep Atas , Buderath Paul , Britten Martin 
Published: February 2025

Abstract

The prevalence of obesity has risen significantly, affecting over 19% of the German population. Obesity is frequently associated with endometrial cancer, presenting considerable challenges in pre-, intra- and postoperative management. Challenges with intubation, patient positioning, respiratory and cardiac complications as well as wound dehiscence are commonly encountered in this patient population. For patients with uterine cancer, surgical intervention is essential for staging, symptom control, and potential cure. Minimally invasive approaches, particularly robotic-assisted surgery, have expanded the possibilities for treating morbidly obese patients. Robotic systems facilitate navigation around anatomical barriers and reduce surgeon fatigue. However, despite the technological advancements, morbidly obese patients often face increased perioperative risks and prolonged postoperative recovery. Laparoscopic procedures in steep Trendelenburg position for morbidly obese patients pose unique challenges, particularly in anesthesiological management. These challenges necessitate individualized ventilatory and hemodynamic support to ensure patient safety. This case highlights a multidisciplinary approach to managing a patient with extreme obesity (BMI 101.7 kg/m²) undergoing robotic-assisted surgery for uterine cancer. It underscores the importance of comprehensive preoperative planning, intraoperative considerations, and postoperative care in minimizing complications and optimizing outcomes. Robotic-assisted surgery for endometrial cancer in obese patients has proven to be a safe and feasible option, characterized by a low complication rate, minimal blood loss, and a short hospital stay.
C-reactive protein to albumin ratio combined with the Systemic Inflammatory Response Index predicts the prognosis of patients undergoing radical hepatectomy
Authors: Lu Shao-Long , Zhang Qing-Yuan , Zhao Yuan-Quan , Wu Hua-Lin , Lin Jie , Zhu Peng , Qin Zheng-Jun , Wang Xiao-Bo , Chen Jie 
Published: February 2025

Abstract

Purpose: Many prognostic scores based on systemic inflammation have been developed. Most of these prognostic scores have been shown to influence the prognosisof hepatocellular carcinoma (HCC) patients. This research aims to develop a novel prognostic system based on inflammatory markers for patients with HCC.
Patients and Methods: This researchencompassed 920 HCC patients who underwent potentially radical surgical resection. We employed receiver-operating characteristic (ROC) curve analysis to determine the optimal cutoff value for the preoperative inflammatory prognostic score. Univariate and multivariate Cox regression analyses were conducted to pinpoint features that significantly influence outcomes for patients with HCC. We employed a calibration curve and decision curve analysis (DCA) to appraise the application of the nomogram.
Results: The multivariate Cox regression identified that systemic immunoinflammatory response index (SIRI), C-reactive protein-albumin ratio (CAR), tumor size, hepatitis B virus (HBV)-DNA, prothrombin time, microvascular invasion, macroscopic vascular invasion, and Edmondson-Steiner grade were all independent predictors of overall survival (OS). The predictive accuracy of the nomogram for estimating 1-, 3-, and 5-year OS was measured by the area under the receiver operating characteristic curve (AUC). Inthe training cohort, the AUC scores for the 1-, 3-, and 5-year OS were 0.815, 0.805, and 0.776. For the validation cohort, the respective AUC scores were 0.814, 0.737, and 0.730. Additionally, our nomogram shows a high capacity for distinguishing between different risk groups and is practical for clinical use.
Conclusion: The nomogram demonstrates strong predictive performance for the 1-, 3-, and 5-year OS of HCC patients undergoing radical surgery, surpassing BCLC and CNLC staging systems in ability to assess patient prognosis.
Efficacy of Topical 2% Carteolol in the Treatment of Infantile Hemangiomas: A Dermoscopic and Clinical Evaluation
Authors: Ünal Esranur , Yücel Muhammed Burak , Gedikli Saadet Nurşah , Ulaş Yılmaz , Mutlu Fatma Türkan , Akay Bengü Nisa 
Published: February 2025

Abstract

Background
Infantile hemangiomas (IH) are the most common benign vascular tumors in infants, often requiring treatment in 10–15% of cases due to complications. While systemic propranolol is the first-line treatment, its potential for systemic side effects raises interest in topical therapies. This study investigates the efficacy of topical 2% carteolol in treating IH and its dermoscopic changes over time.
Methods
A total of 15 patients with IH were treated with topical 2% carteolol drops applied twice daily for 3 months. Clinical and dermoscopic images were captured at baseline, 1 month, and 3 months. Dermoscopic features such as erythema, clods, coiled vessels, dotted vessels, and others were evaluated. Visual Analog Scale (VAS) scores were used to assess treatment response.
Results
The most frequent dermoscopic findings at baseline were coiled vessels, followed by serpentine and dotted vessels. At 1 and 3 months, significant improvements were observed, with reductions in erythema and coiled vessel scores (p < 0.05) and at 3 months with reductions in clod score (p < 0.05). The skin-colored structureless area significantly increased, indicating lesion regression (p < 0.05). VAS scores showed a significant decrease over the 3-month period, with a positive correlation between baseline dotted vessel scores and treatment response (r:0.656, p:0.008).
Conclusions
Topical 2% carteolol is an effective and safe treatment for IH. Dermoscopic monitoring provides valuable insights into treatment progression, showing significant changes in erythema, clod, and vascular patterns. The presence of dotted vessels at baseline may serve as a predictor of a favorable treatment response. Further studies with longer follow-up are needed to validate these findings.
Mitochondrial-Derived Vesicles Mediate Interorganellar Communication via Selective Cargo Transfer Under Oxidative Stress
Authors: Sharma Ashutosh 
Published: February 2025

Abstract

Mitochondrial-derived vesicles (MDVs) are essential for mitochondrial quality control, yet their cargo specificity and role in interorganellar communication remain poorly characterized. Here, we demonstrate that under oxidative stress, MDVs selectively transport antioxidant enzymes (e.g., peroxiredoxin-3, SOD1) to peroxisomes and lysosomes via Rab32-dependent trafficking. Using super-resolution microscopy and SILAC-based proteomics in HeLa and primary murine fibroblast models, we observed a 3-fold increase in MDV biogenesis post-H2O treatment (p < 0.001), with Rab32 knockout cells exhibiting 50% higher cytosolic mitochondrial DNA (mtDNA) leakage and NLRP3 inflammasome activation. Live-cell imaging confirmed MDV-peroxisome fusion via PEX14 and lysosomal delivery via LAMP1, revealing a redox-sensitive mechanism that prevents oxidative damage. These findings establish MDVs as critical mediators of interorganellar coordination, offering novel therapeutic strategies for diseases linked to mitochondrial dysfunction, such as Parkinson’s disease.
Leveraging GANs For Active Appearance Models Optimized Model Fitting
Authors: Awasthi Anurag 
Published: February 2025

Abstract

Generative Adversarial Networks (GANs) have gained prominence in refining model fitting tasks in computer vision, particularly in domains involving deformable models like Active Appearance Models (AAMs). This paper explores the integration of GANs to enhance the AAM fitting process, addressing challenges in optimizing nonlinear parameters associated with appearance and shape variations. By leveraging GANs' adversarial training framework, the aim is to minimize fitting errors and improve convergence rates. Achieving robust performance even in cases with high appearance variability and occlusions. Our approach demonstrates significant improvements in accuracy and computational efficiency compared to traditional optimization techniques, thus establishing GANs as a potent tool for advanced image model fitting.
Chronic Infections of Knee Megaprostheses: Is "Off-Label" DAIR-Plus an Option?
Authors: Stimolo Davide , Innocenti Matteo , Carminati Mattia , Castrogiovanni Filippo , Neri Elisabetta , Campanacci Domenico Andrea , Scoccianti Guido 
Published: February 2025

Abstract

Introduction
Two-stage revision for chronic periprosthetic joint infections (PJI) of knee megaprostheses is complex and often results in significant bone loss. The DAIR-plus (DP) procedure, involving debridement with partial prosthesis removal but retaining stems, is typically used for acute PJI but may benefit select chronic cases. This study aimed to: i) assess DP outcomes in chronic megaprosthesis infections; and ii) identify prognostic factors to guide its use versus full component removal.
Material and Methods
Twenty-three patients underwent DP procedures for chronic knee megaprosthetic PJI between 2000 and 2022. Nineteen patients, were included. Targeted antibiotics were administered based on Infectious Disease Specialist recommendations. Infection eradication was evaluated using clinical and serologic parameters.
Results
The study involved 12 females and 7 males aged 18–87 (mean 53); twelve had oncological conditions. DP was performed as a one-stage procedure in 13 cases and two-stage in 6. Eight patients (42%) achieved infection resolution with DP alone, and four required additional procedures, yielding an overall success rate of 63%. Some required amputation or chronic antibiotics. Outcomes did not significantly differ by age (p = 0,85), gender (p = 0.31), oncology status (p = 0,95), radiotherapy (p = 0,43), previous revisions (p = 0,43), or revision type (p = 0,44). Staphylococcus spp infections had worse outcomes (25% vs. 62%, p = 0.048).
Conclusions
The DAIR-plus procedure is a viable option for selected patients, though it carries a high failure risk (over 50%). When successful, it offers notable advantages such as bone stock preservation and faster recovery. Infections caused by Staphylococcus spp. present greater challenges for eradication in this series.
Quantum teleportation of a photon via absorption and emission for quantum repeater nodes
Authors: Reyes Raustin , Sekiguchi Yuhei , Ito Daisuke , Fujiwara Taichi , Watanabe Kansei , Makino Toshiharu , Kato Hiromitsu , Kosaka Hideo 
Published: February 2025

Abstract

Absorption and emission, fundamental interactions between light and matter, enable the regeneration of a quantum state of light via matter through concatenated quantum state transfer based on the principle of quantum teleportation. This transfer is enabled by electron spin‒orbit entanglement and electron‒nuclear spin entanglement inherent within the material. Here, we demonstrate that a photon quantum state imprinted in polarization is transferred to another photon emitted from a nitrogen vacancy (NV) center. This transfer is heralded by the result of the Bell state measurement between the electron and nitrogen nuclear spins. We show that the minimum number of incident photons needed to achieve transfer is, on average, only 0.1 photons, enabling quantum teleportation over 10 km. This demonstration paves the way for a fault-tolerant quantum repeater that is robust against phase and intensity errors, unlike the conventional photon interference scheme, thereby facilitating practical quantum networks.
Systematic Review to Assess the Efficacy of Buprenorphine Compared to Methadone as an Intervention for Opiate Dependency
Authors: Adams Sherifdeen 
Published: February 2025

Abstract

Objective
To assess the efficacy of buprenorphine compared to methadone as an intervention for opiate dependency.
Data Sources:
Electronic databases (MEDLINE, PubMed, PsychARTICLES, ProQuest, ScienceDirect, PsychINFO and Web of Science)
Study Selection:
Published studies from 2000–2014 relating to the efficacy of buprenorphine and methadone as maintenance treatments for opioid dependence. These studies included those that looked at retention and relapse rates, had quantitative evidence, and looked at both males and females. Eight out of 20 studies met these inclusion criteria and were included in the systematic review.
Results
The studies looked at efficacy in terms of retention and relapse rates. With regards to retention, three studies found methadone to be more effective than buprenorphine and the other five found no significant differences between the two groups. In terms of relapse measured by urinalysis, four studies found significantly lower positive opiate urine samples in the buprenorphine group and the other four found no significant difference between the two groups. Several problems have been identified with the research studies used. These include no long-term follow-up, potential for participation bias, varied number of participants across studies and the widely varied length of time studies were conducted over.
Conclusion
This systematic review hasn’t helped to resolve the conflicting research in this area. It has further been confounded by the inconsistencies of the research methodologies utilised which has created problems in making any meaningful comparisons. This highlights the need for a standardised shared approach to undertaking research in a way that promotes the opportunity for aggregating research data in a meaningful way. The urgency for this is even greater given the imminent introduction of a buprenorphine depot alternative which could potentially add another layer of clinical uncertainty if not resolved.
Подсолнечная лузга как сырьё для плит типа ДСП
Authors: Леонович А. А. , Замазий Л. В. 
Published: February 2025

Изучали особенности свойств оболочек семян подсолнечника с целью использования лузги при изготовлении плитных материалов. Для ликвидации неприемлемой формы «лодочки» придавали им форму плоских частиц пропусканием лузги через валки с задаваемой величиной просвета 0,1…0,4 мм. Установили ухудшение смачиваемости раствором карбамидоформальдегидного связующего наружных и внутренних поверхностей при нагревании до температуры 140 °С. Установили повышенную по сравнению с древесиной жёсткость лузги в отношении размягчения и граничные значения параметров горячего прессования, которые лежат в пределах от 241 ± 2 °С – нижнее значение, до 256 °С – верхнее значение, которое лимитируется активным термическим разложением вещества лузги. Для практического использования лузги в производстве плит требуется включить в технологию повышенный расход связующего или разработать подходящие приёмы пластификации лузги для снижения температуры размягчения и возможности использования прессового оборудования, потенциал для модернизации которого уже исчерпан. Вероятная область изготовления плитного материала из лузги – строительство, вероятные марки плит – Р-1 и Р-2.
The properties of sunflower seed shells were studied in order to use husks in the manufacture of slab materials. To eliminate the unacceptable shape of the "boats", they were shaped into flat particles by passing husks through rolls with a set lumen value of 0.1...0.4 mm. A deterioration in the wettability of the urea-formaldehyde binder solution of the outer and inner surfaces was found when heated to a temperature of 140 °C. The hardness of the husk increased in terms of softening compared to wood and the boundary values of the hot pressing parameters, which range from 241 ± 2 °C – the lower value, to 256 °C – the upper value, which is limited by the active thermal decomposition of the husk substance, were established. For the practical use of husks in the production of plates, it is necessary to include increased binder consumption in the technology or develop suitable husk plasticization techniques to reduce the softening temperature and the possibility of using pressing equipment, the potential for modernization of which has already been exhausted. The probable area of manufacture of slab material from husk is construction, the probable grades of plates – P-1 and P-2.
Оценка качества таксации по результатам лесотаксационного дешифрирования данных спутниковой съемки Sentinel-2
Authors: Капиталинин Д. Ю. , Сидоренков В. М. , Ачиколова Ю. С. , Астапов Д. О. , Рябцев О. В. , Щекалев Р. В. 
Published: February 2025

В статье рассматривается технология оценки качества материалов таксации леса на основе анализа связей таксационных показателей насаждений с их спектрально-отражательными характеристиками. При проведении исследований используются данные спутниковой съемки Sentinel-2 в видимом и инфракрасном диапазоне спектра с пространственным разрешением 10 м.
The article considers the technology of assessing the quality of forest taxation materials based on the analysis of the relationship between the taxation indicators of plantations and their spectral-reflective characteristics. The research uses Sentinel-2 satellite imagery data in the visible and infrared spectral ranges with a spatial resolution of 10 m.
Response of discharge in the Upper Yellow River Basin to changing climate over the long time period (1850–2023)
Authors: Chen Ziyan , Su Buda , Fohrer Nicola , Huang Jinlong , Zhao Mengxia , Wen Shanshan , Jiang Tong 
Published: February 2025

ABSTRACT

Previous studies addressing climate change impacts on discharge typically focused on limited periods, beginning with the earliest available observed data. This study extends the timeline to 1850–2023 using global climate models containing scenarios of both historical simulations (under climate change) and pre-industrial control (piControl, with greenhouse gases, aerosols, ozone, and solar irradiance fixed at 1850 levels) to drive hydrological models. Key findings include: (1) Basin average annual mean temperature has increased and precipitation has decreased from 1850 to 2023. With more pronounced climate change impacts in the late 20th and early 21st centuries, discharge in historical simulations decreased by up to 7% relative to piControl over the same period after 1970. (2) Climate change has increased discharge from March to May but decreased it in other months, particularly October, where historical simulations showed as much as a 25% decrease compared to piControl in recent decades. (3) Extreme high and low flows have decreased due to climate change, with decreases of up to 8 and 6%, respectively, after 2000, when compared to piControl. This study underscores the growing climate change impact on discharge, providing insights for disaster risk management and water resource planning in the Upper Yellow River (UYR).
Revisiting the Role of Long Non-coding RNA PSMA3-AS1 in Human Cancers: Current Evidence and Future Directions
Authors: Yang Jingjie , Liu Kexing , Chen Lihan , He Haodong , Li Tongtong , Li Li , Li Xiaolan , Yuan Chengfu 
Published: February 2025

Abstract:
Long non-coding RNAs (lncRNAs) refer to RNA molecules that exceed 200 nucleotides in length.
While lncRNAs do not possess the capacity to encode proteins, they play crucial roles in gene expression, chromatin
remodeling, and protein relocation. PSMA3 antisense RNA 1 (PSMA3-AS1) is a newly discovered lncRNA
located on human chromosome 14q23.1. Convincing evidence shows that it acts as a tumor-promoting factor
in several forms of human cancers. Moreover, high expression of PSMA3-AS1 is linked to poor clinical
and pathological features and adverse prognosis in eight types of cancer. The molecular mechanisms of PSMA3-
AS1 are diverse and complex. Existing evidence demonstrates that PSMA3-AS1 is activated by two transcription
factors, PAX5 and YY-1, and influences cancer cell growth, metastasis, apoptosis, drug resistance,
oxidative stress, and autophagy by acting as a competing endogenous RNA, activating signaling pathways, directly
interacting with RNA or proteins, as well as participating in the epithelial-mesenchymal transition process.
Therefore, PSMA3-AS1 holds promise as a biomarker for cancer detection and prediction, as well as a
novel therapeutic target. This review explores the expression features, biological roles, potential mechanisms,
and clinical significance of PSMA3-AS1 in various human cancers and provides directions for future research.
Efficient Synthesis, Characterization, and Molecular Docking Studies of Some Novel Benzothiazolamine-Based Terephthaloyl Bisthioureas and Investigation of their Potent Antioxidant Activities
Authors: Naseem Muhammad , Rafique Hummera , Roshan Sadia , Malik Fouzia Perveen , Tayyab Muhammad 
Published: February 2025

Abstract:
Variously substituted benzothiazolamines were prepared and employed as starting material to synthesize
some new benzothiazolamine-based bis-thiourea derivatives, such as N3, N3’-bis(6-substituted benzothiazolyl)
terephthaloyl-bis(thioureas). Molecular modeling of all the synthesized compounds was carried out to
check the interactions of all the bis-thiourea ligands inside the active pocket of enzyme 3MNG in comparison to
competitive antioxidant inhibitor DTT (1,2-dithiane-4,5-diol). The antioxidant activities of all the synthesized
compounds were determined using a DPPH radical assay performed by standard methods. Benzothiazole-based
bis-thiourea derivatives exhibited significant potent antioxidant properties.
Kojic Acid - A Blossoming Scaffold of Biological Significance: An Overview of Synthesis, Properties, and Biological Applications
Authors: Bhardwaj Arpana , Saroha Bhavna , Bishnoi Poonam , Kumar Gourav , Kumar Ramesh , Kumar Suresh 
Published: February 2025

Abstract:
Kojic Acid (KA) is an oxygen-based heterocycle of natural occurrence and is chemically known as 5-
hydroxy-2-(hydroxymethy1)-4H-pyran-4-one. This review has been designed to lighten up the various biological
potentials, including the tyrosinase inhibition potential and depigmenting action of KA and its derivatives.
KA has very interesting physical and chemical properties and has many applications in the medicinal and cosmetic
industries, like antimicrobial, antifungal, antitumor, anti-inflammatory, and depigmentation activities.
Despite its medicinal importance, KA possesses a fascinating structure with multiple reactive centers, making it
valuable in various chemical transformations. Therefore, a variety of KA derivatives have been/may be prepared
with improved stability and with more effective and interesting biological activities than KA itself. Here, in this
review, we have briefly described the biological activities of some potent KA derivatives with a brief introduction
to the physical and chemical properties of KA. This review would bridge the gap between basic research
and applied science, offering value to both scientific and industrial communities.