bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Board Certified Psychiatric Pharmacists on improving urinary tract infection antibiotic appropriateness at an acute psychiatric hospital
Authors: Hamad Mohammad Adam , Williams Andrew , Kneebusch Jamie , Butala Niyati 
Published: October 2023

Abstract

Introduction
Urinary tract infections (UTIs) are one of the most common indications for antibiotic use; patients with psychiatric disorders have a greater risk for UTI compared with patients without these disorders. However, there is little guidance on how best to manage antibiotic therapy in psychiatric hospitals. This study assessed the impact of a Board Certified Psychiatric Pharmacist (BCPP)–driven guideline on managing UTI treatment in an acute psychiatric hospital.

Methods
The guideline was developed by the psychiatric pharmacy team and distributed to internists, psychiatrists, and pharmacists. Preintervention data were assessed for patients admitted between November 30, 2019, and February 23, 2020; postintervention data were assessed from February 25, 2020, to April 24, 2020. All patients ages 13 years and older who were admitted and had orders for an antibiotic to treat a UTI were included in this study. Appropriate UTI management was defined as an appropriate agent, dose, route, and frequency per the treatment guideline. Additionally, the following criteria were to be ordered and assessed to be deemed appropriate: urinalysis, urine culture, complete blood count, basic or complete metabolic panel, temperature, and subjective symptoms.

Results
Before intervention, 19.0% of antibiotic orders were appropriate; after intervention, 46.7% of antibiotic orders were appropriate (P = .048).

Conclusion
The implementation of a BCPP-driven treatment algorithm was associated with a significant increase in appropriate antibiotic regimens for the treatment of UTIs in patients admitted to a psychiatric hospital.
Intranasal ketamine as a treatment for psychiatric complications of long COVID: A case report
Authors: Baldwin Kaitlyn , Wanson Annabelle , Gilecki Lee-Anne , Dalton Courtney , Peters Evyn , Halpape Katelyn 
Published: October 2023

Abstract

Background
Neuropsychiatric symptoms associated with long COVID are a growing concern. A proposed pathophysiology is increased inflammatory mediators. There is evidence that typical serotonergic antidepressants have limited efficacy in the presence of inflammation. Although ketamine has shown promise in MDD, there is limited evidence supporting the use of ketamine to treat depressive symptoms associated with long COVID.

Case Report
This case took place on an inpatient psychiatry unit in a Canadian hospital. The patient was admitted with a 10-month history of worsening depression and suicidality following infection with COVID-19. Depressive symptoms and suicidal ideation were assessed throughout treatment using the Montgomery-Asberg Depression Rating Scale (MADRS). Written informed consent was obtained prior to data collection. This patient received 4 doses of intranasal ketamine which resulted in rapid improvement of depressive symptoms and complete resolution of suicidality with no major adverse events.

Discussion
There is evidence to support long COVID symptoms result from dysregulated inflammatory processes. The presence of inflammation in patients with MDD has correlated to poor outcomes with first-line antidepressants. It has been demonstrated that IV ketamine is associated with decreased inflammatory mediators and proportional decrease in depressive symptoms.

Conclusions
Intranasal ketamine in this case was effective at treating depressive symptoms and suicidal ideation associated with long COVID. This is consistent with available data that demonstrates ketamine's efficacy in reducing inflammatory mediators associated with neuropsychiatric symptoms. Therefore, ketamine may be a potential therapeutic option to treat long COVID and persistent depressive symptoms.
Prevalence, Severity, and Measures of Anxiety in Rheumatoid Arthritis: A Systematic Review
Authors: Meade Tanya , Joyce Caroline , Perich Tania , Manolios Nicholas , Conaghan Phillip G. , Katz Patricia 
Published: October 2023

ObjectiveMany studies have reported high rates of anxiety in adults with rheumatoid arthritis (RA). The aim of this systematic review was to examine those findings and determine the overall prevalence, severity, and commonly used measures of anxiety in individuals with RA.MethodsSix databases were searched from January 2000 without restrictions on language/location, study design, or gray literature. All identified studies that examined anxiety prevalence and severity in adults with RA, as assessed with clinical diagnostic interview and/or standardized self‐report measures, were considered for inclusion. Quality assessment of included studies was conducted using a modified Newcastle‐Ottawa Evaluation Scale, and the findings were synthesized via a narrative approach.ResultsAcross the 47 studies (n = 11,085 participants), the sample size ranged from 60 to 1,321 participants with seven studies including healthy controls or groups with other health conditions. The studies were conducted across 23 countries, and anxiety prevalence ranged from 2.4% to 77%, predominantly determined with standardized self‐report measures, of which Hospital Anxiety and Depression scale was used most frequently; only eight studies used a clinical diagnostic interview to confirm a specific anxiety diagnosis. Notable associations with anxiety in RA were physical disability, pain, disease activity, depression, and quality of life.ConclusionThe reported prevalence of anxiety in RA varied widely potentially because of use of different self‐report measures and cutoff points. Such cutoff points will need to be standardized to clinical thresholds to inform appropriate interventions for anxiety comorbidity in RA.
A Soft, Adhesive Self‐Healing Naked‐Eye Strain/Stress Visualization Patch
Authors: Zhao Zhi , Liu Junjie , Wu Mengfei , Yao Xuan , Wang Haibin , Liu Xuemei , He Zhibin , Song Xiaoyan 
Published: October 2023

AbstractLearning about the strain/stress distribution in a material is essential to achieve its mechanical stability and proper functionality. Conventional techniques such as universal testing machines only apply to static samples with standardized geometry in laboratory environment. Soft mechanical sensors based on stretchable conductors, carbon‐filled composites, or conductive gels possess better adaptability, but still face challenges from complicated fabrication process, dependence on extra readout device, and limited strain/stress mapping ability. Inspired by the camouflage mechanism of cuttlefish and chameleons, here an innovative responsive hydrogel containing light‐scattering “mechano‐iridophores” is developed. Force induced reversible phase separation manipulates the dynamic generation of mechano‐iridophores, serving as optical indicators of local deformation. Patch‐shaped mechanical sensors made from the responsive hydrogel feature fast response time (<0.4 s), high spatial resolution (≈100 µm), and wide dynamic ranges (e.g., 10–150% strain). The intrinsic adhesiveness and self‐healing material capability of sensing patches also ensure their excellent applicability and robustness. This combination of chemical and optical properties allows strain/stress distributions in target samples to be directly identified by naked eyes or smartphone apps, which is not yet achieved. The great advantages above are ideal for developing the next‐generation mechanical sensors toward material studies, damage diagnosis, risk prediction, and smart devices.
Direct Generation of N‐Alkoxycarbonyl Nitrones from Oximes: Intramolecular Cycloaddition of Oximes Having Alkene Moieties
Authors: Sagara Hiroto , Suzuki Yoshio , Morita Nobuyoshi , Ban Shintaro , Tanaka Kosaku , Yamamoto Ayaka , Hashimoto Yoshimitsu , Tamura Osamu 
Published: October 2023

Abstractδ,ϵ‐Unsaturated oximes, on heating with O‐alkyl S‐(pyridin‐2‐yl)carbonothioates (PySCO2R) in refluxing toluene, undergo intramolecular cycloaddition to give N‐alkoxycarbonylated multi‐cyclic compounds. Mechanistic studies indicate that the reaction involves direct generation of N‐alkoxycarbonyl nitrones followed by cycloaddition, instead of intramolecular oxime‐olefin cycloaddition (IOOC) followed by alkoxycarbonylation. DFT calculation indicates that N‐alkoxycarbonylation of oxime with PySCO2R is a concerted reaction. The reaction of oxime with a chiral alkoxycarbonylation reagent exhibits a reasonably high diastereo‐face selectivity.
Aggregation induced edge sites actuation of 3D MoSe2/rGO electrocatalyst for high‐performing water splitting system
Authors: Janani Gnanaprakasam , Surendran Subramani , Lee Dong‐Kyu , Shanmugapriya Sathyanarayanan , Lee Hyunjung , Subramanian Yuvaraj , Sim Uk 
Published: October 2023

Abstract2D materials are regarded as promising electrocatalysts for water splitting because of their advances in providing ample active sites and improving electrochemical reaction kinetics. 2D MoSe2 has a greater intrinsic electrical conductivity and lower Gibbs free energy for reactant adsorption. However, there is still room for improvement in the electrocatalytic performance of MoSe2 for high‐performance electrochemical water splitting devices. Herein, the in situ preparation of heterostructure made of covalently bonded MoSe2 and rGO is reported. The obtained electrocatalyst contains the aggregated 3D structured MoSe2 over rGO, which is covalently bonded together with more edge sites. The active edge sites of MoSe2/rGO are dynamically involved in the electrocatalytic activity while facilitating electron transfer. Hence, the MoSe2/rGO heterostructure requires a low cell voltage of 1.64 V to reach 100 mA cm−2 in water splitting with high reaction kinetics. The aggregated MoSe2 over rGO with more edge sites exposed by the 3D structure of MoSe2 and the interfacial covalent bond in between them provides a favorable electronic structure for the HER and OER with low overpotentials and high current densities and enhances the stability of the electrocatalyst. This work presents an attractive and cost‐effective electrocatalyst suitable for industrial‐scale hydrogen fuel production.
Black Rain: a kaupapa Māori (a Māori approach) to addressing family violence and intergenerational trauma
Authors: Pouesi Fay , Dewerse Rosemary 
Published: October 2023

AbstractIn working with Māori to address family violence and the trauma that arises when it is occurring across generations, three elements are essential. The first is helping whānau (family members) to recognise and reconnect with the impact of the violence they are caught up in. The second is to do so in a way that contextualises this because it never involves and affects individuals alone. And third is to do so by being conscious of the whole of a person's being and being aware that the spiritual realm is the entry point. For 30 years, Fay Pouesi has been working with Māori whānau, initiating kaupapa (approaches) that include these three elements. This article details one kaupapa, known as Black Rain, which has been successfully helping men and women to break the cycles of intergenerational violence within their whānau since 2010. To do this, we will draw upon Fay's work and that of two colleagues who now work with her.
Identification of priority cetacean areas in the north‐east Atlantic using systematic conservation planning
Authors: Giménez Joan , Waggitt James J. , Jessopp Mark 
Published: October 2023

Abstract

Mobile marine protected areas have been proposed for the conservation of highly seasonal or mobile marine megafauna. However, seasonal data on the distribution of marine wildlife to inform protected areas are generally scarce worldwide, especially for cetaceans, which makes dynamic solutions difficult to implement.
Furthermore, conservation objectives are often set at the level of individual species rather than at the community level, despite many species having similar or overlapping habitat requirements, and a comparison of the effectiveness of mobile vs. static Marine Protected Areas options has rarely been done.
Systematic conservation planning was used to identify priority areas of cetacean biodiversity in the north‐east Atlantic accounting for seasonal changes in distribution. Consistent hotspots across seasons at a community level, in particular along the shelf edge, suggest that fixed priority areas for cetacean biodiversity may be appropriate.
The area required for protection to meet conservation targets (i.e. 20% of a population occurring within a protected area) is minimized when considering populations at basin scale rather than national level. Highly mobile megafauna normally exploit persistent and predictable oceanographic features, so a habitat suitability rather than a jurisdiction‐based approach is more appropriate.
Impact of bacterial admixtures on the compressive and tensile strengths, permeability, and pore structure of ternary mortars: Comparative study of ureolytic and phototrophic bacteria
Authors: Aceituno‐Caicedo David , Shvarzman Asia , Zhutovsky Semion , Dittrich Maria 
Published: October 2023

AbstractThe addition of bacterial biomass to cementitious materials can improve strength and permeability properties by altering the pore structure. Photoautotrophic bacteria are understudied mortar bio‐additives that do not produce unwanted by‐products compared to commonly studied ureolytic species. This study directly compares the impact of the addition of heterotrophic Bacillus subtilis to photoautotrophic Synechocystis sp. PCC6803 on mortar properties and microstructure. Cellulose fibers were used as a bacteria carrier. A commercial concrete healing agent composed of dormant bacterial spores was also tested. Strength, water absorption tests, mercury intrusion porosimetry, differential scanning calorimetry, thermogravimetric analysis, and scanning electron microscopy were applied to experimental mortar properties. The photoautotrophic modifications had a stronger positive impact on mortar strength and permeability properties than sporulated heterotrophic modifications due to differences in surface properties and production of exopolysaccharides. The findings provide support for photoautotrophic species as additives for mortars to move away from ammonia‐generating species.
Evoking surface‐driven capacitive process through sulfur implantation into nitrogen‐coordinated hard carbon hollow spheres achieves superior alkali metal ion storage beyond lithium
Authors: Wang Gongrui , Gao Jingyu , Wang Wentao , Tao Zongzhi , He Xiaoyue , Shi Liang , Zhang Genqiang 
Published: October 2023

AbstractOwing to the specific merits of low cost, abundant sources, and high physicochemical stability, carbonaceous materials are promising anode candidates for K+/Na+ storage, whereas their limited specific capacity and unfavorable rate capability remain challenging for future applications. Herein, the sulfur implantation in N‐coordinated hard carbon hollow spheres (SN‐CHS) has been realized for evoking a surface‐driven capacitive process, which greatly improves K+/Na+ storage performance. Specifically, the SN‐CHS electrodes deliver a high specific capacity of 480.5/460.9 mAh g−1 at 0.1 A g−1, preferred rate performance of 316.8/237.4 mAh g−1 at 5 A g−1, and high‐rate cycling stability of 87.9%/87.2% capacity retention after 2500/1500 cycles at 2 A g−1 for K+/Na+ storage, respectively. The underlying ion storage mechanisms are studied by systematical experimental data combined with theoretical simulation results, where the multiple active sites, improved electronic conductivity, and fast ion absorption/diffusion kinetics are major contributors. More importantly, the potassium ion hybrid capacitor consisting of SN‐CHS anode and activated carbon cathode deliver an outstanding energy/power density (189.8 Wh kg−1 at 213.5 W kg−1 and 9495 W kg−1 with 53.9 Wh kg−1 retained) and remarkable cycling stability. This contribution not only flourishes the prospective synthesis strategies for advanced hard carbons but also facilitates the upgrading of next‐generation stationary power applications.
Transition Metal‐Catalyzed Migratory Tsuji‐Trost Reaction
Authors: Chen Xian‐Xiao , He Zhi‐Tao 
Published: October 2023

AbstractBeyond the scope of classical Tsuji‐Trost reaction, an alkene bearing a remote leaving group is not considered as a potential substrate for allylation. The concept of migratory Tsuji‐Trost reaction focuses on the transformations with this type of substrates. Two pathways including olefin migration and leaving group migration to form typical allyl intermediate for following substitution have been explored to demonstrate the feasibility of this new concept.
Strong Antiferromagnetic Exchange‐Coupling Observed in Hydride‐Bridged Dimeric Dysprosium(III) Single‐Molecule Magnet
Authors: Luo Qian‐Cheng , Yu Ke‐Xin , Jin Peng‐Bo , Liu Ye‐Ye , Zhai Yuan‐Qi , Zheng Yan‐Zhen 
Published: October 2023

Comprehensive SummaryOne dihydride‐bridged dimeric Dy(III) guanidinate complex, formulated as [{(Me3Si)2NC(NiPr)2}2Dy(μ‐H)]2 (1Dy), was successfully isolated and the introduction of hydride bridges significantly reduces the intramolecular Dy(III)···Dy(III) distance to only 3.688(1) Å. To investigate the effect of such a short Dy(III)···Dy(III) distance on magnetism, we also prepared its dibromide‐bridged analogue [{(Me3Si)2NC(NiPr)2}2Dy(μ‐Br)]2 (2Dy), which has a much longer Dy(III)···Dy(III) distance of 4.605(4) Å. Surprisingly, 2Dy demonstrates much larger effective energy barrier for magnetization reversal (Ueff) and higher blocking temperature (TB). The worse performance of 1Dy is attributed to the concerted effect of strong antiferromagnetic interactions between Dy(III) ions (Jtotal = –2.683 cm–1) and the unparallel arrangement of magnetic principle axes of the Dy(III) ions for 1Dy.
Soft‐switched full‐bridge light‐emitting diode driver with reduced rectifier components
Authors: Chandrasekhar Valluru , Vishwanathan Neti , Kolla Hemasundara Rao 
Published: October 2023

SummaryIn this paper, a new light‐emitting diode (LED) driver based on full‐bridge series resonant converter (SRC) is presented. In the proposed converter LED, load is placed in between DC source and the input side of the full‐bridge inverter which reduces the rectifier components of the SRC. The proposed converter reduces the number of diodes used for rectification and ensures zero voltage switching of the power switches which improves the efficiency of the converter. LED lamp current is regulated with phase‐shift pulse width modulation (PWM) of full‐bridge. Lamp illumination is controlled with PWM dimming. The operation and mathematical analysis of LED driver is presented. To validate the proposed concept, a 40‐W laboratory prototype is developed. Experimental results are presented. Peak efficiency of 93% is obtained.
Evolution of five environmentally responsive gene families in a pine‐feeding sawfly, Neodiprion lecontei (Hymenoptera: Diprionidae)
Authors: Vertacnik Kim L. , Herrig Danielle K. , Godfrey R. Keating , Hill Tom , Geib Scott M. , Unckless Robert L. , Nelson David R. , Linnen Catherine R. 
Published: October 2023

AbstractA central goal in evolutionary biology is to determine the predictability of adaptive genetic changes. Despite many documented cases of convergent evolution at individual loci, little is known about the repeatability of gene family expansions and contractions. To address this void, we examined gene family evolution in the redheaded pine sawfly Neodiprion lecontei, a noneusocial hymenopteran and exemplar of a pine‐specialized lineage evolved from angiosperm‐feeding ancestors. After assembling and annotating a draft genome, we manually annotated multiple gene families with chemosensory, detoxification, or immunity functions before characterizing their genomic distributions and molecular evolution. We find evidence of recent expansions of bitter gustatory receptor, clan 3 cytochrome P450, olfactory receptor, and antimicrobial peptide subfamilies, with strong evidence of positive selection among paralogs in a clade of gustatory receptors possibly involved in the detection of bitter compounds. In contrast, these gene families had little evidence of recent contraction via pseudogenization. Overall, our results are consistent with the hypothesis that in response to novel selection pressures, gene families that mediate ecological interactions may expand and contract predictably. Testing this hypothesis will require the comparative analysis of high‐quality annotation data from phylogenetically and ecologically diverse insect species and functionally diverse gene families. To this end, increasing sampling in under‐sampled hymenopteran lineages and environmentally responsive gene families and standardizing manual annotation methods should be prioritized.
Complex nonmonotonic responses of biodiversity to habitat destruction
Authors: Zhang Helin , Bearup Daniel , Barabás György , Fagan William F. , Nijs Ivan , Chen Dongdong , Liao Jinbao 
Published: October 2023

AbstractIt has typically been assumed that habitat destruction, characterized by habitat loss and fragmentation, has consistently negative effects on biodiversity. While numerous empirical studies have shown the detrimental effects of habitat loss, debate continues as to whether habitat fragmentation has universally negative effects. To explore the effects of habitat fragmentation, we developed a simple model for site‐occupancy dynamics in fragmented landscapes. With the model, we demonstrate that a competition–colonization trade‐off can result in nonlinear oscillatory responses in biodiversity to both habitat loss and fragmentation. However, the overall pattern of habitat loss reducing species richness is still established, in line with empirical observations. Interestingly, the existence of localized oscillations in biodiversity can explain the mixed responses of species richness to habitat fragmentation per se observed in nature, thereby reconciling the debate on the fragmentation–diversity relationship. Therefore, this study offers a parsimonious mechanistic explanation for empirically observed biodiversity patterns in response to habitat destruction.
Influences of nonlinear parameters on the performance of a free‐piston Stirling engine
Authors: Ye Wenlian , Wang Weijie , Yan Yuqin , Kong Lingxuan , Liu Yingwen 
Published: October 2023

AbstractThis study presents a thermodynamic–dynamic model of a free‐piston Stirling engine (FPSE) with nonlinear coefficients of spring, load damping, and pressure for working spaces. The effects of the nonlinear coefficients of hardening and softening springs on the movement and operating frequency of a displacer and piston are investigated. Subsequently, the influences of the nonlinear pressure terms of the working space and buffer spaces, as well as the nonlinear coefficients of the load on the amplitudes of the two pistons, frequency, and output powers are discussed. The results indicate that the low nonlinear coefficients of the spring have a minor effect on the amplitudes and frequency. As the high nonlinear coefficients of the hardening spring increase, the amplitudes and output power decrease, while the frequency increases. As the nonlinear terms of the softening spring increase, the amplitudes and output power reach maximum values, but the frequency is reduced by 3.55%. The effects of the nonlinear pressure terms on the amplitudes and output power are not evident. However, an increase in the nonlinear load leads to a significant decrease in the FPSE's performance.