bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust recurrent graph convolutional network approach based sequential prediction of illicit transactions in cryptocurrencies
Authors: Alarab Ismail , Prakoonwit Simant 
Published: December 2023

AbstractMoney laundering has urged the need for machine learning algorithms for combating illicit services in the blockchain of cryptocurrencies due to its increasing complexity. Recent studies have revealed promising results using supervised learning methods in classifying illicit Bitcoin transactions of Elliptic data, one of the largest labelled data of Bitcoin transaction graphs. Nonetheless, all learning algorithms have failed to capture the dark market shutdown event that occurred in this data using its original features. This paper proposes a novel method named recurrent graph neural network model that extracts the temporal and graph topology of Bitcoin data to perform node classification as licit/illicit transactions. The proposed model performs sequential predictions that rely on recent labelled transactions designated by antecedent neighbouring features. Our main finding is that the proposed model against various models on Elliptic data has achieved state-of-the-art with accuracy and $$f_1$$

f
1

-score of 98.99% and 91.75%, respectively. Moreover, we visualise a snapshot of a Bitcoin transaction graph of Elliptic data to perform a case study using a backward reasoning process. The latter highlights the effectiveness of the proposed model from the explainability perspective. Sequential prediction leverages the dynamicity of the graph network in Elliptic data.
Reliability evaluation of reinforcement learning methods for mechanical systems with increasing complexity
Authors: Manzl Peter , Rogov Oleg , Gerstmayr Johannes , Mikkola Aki , Orzechowski Grzegorz 
Published: December 2023

AbstractReinforcement learning (RL) is one of the emerging fields of artificial intelligence (AI) intended for designing agents that take actions in the physical environment. RL has many vital applications, including robotics and autonomous vehicles. The key characteristic of RL is its ability to learn from experience without requiring direct programming or supervision. To learn, an agent interacts with an environment by acting and observing the resulting states and rewards. In most practical applications, an environment is implemented as a virtual system due to cost, time, and safety concerns. Simultaneously, multibody system dynamics (MSD) is a framework for efficiently and systematically developing virtual systems of arbitrary complexity. MSD is commonly used to create virtual models of robots, vehicles, machinery, and humans. The features of RL and MSD make them perfect companions in building sophisticated, automated, and autonomous mechatronic systems. The research demonstrates the use of RL in controlling multibody systems. While AI methods are used to solve some of the most challenging tasks in engineering, their proper understanding and implementation are demanding. Therefore, we introduce and detail three commonly used RL algorithms to control the inverted N-pendulum on the cart. Single-, double-, and triple-pendulum configurations are investigated, showing the capability of RL methods to handle increasingly complex dynamical systems. We show 2D state space zones where the agent succeeds or fails the stabilization. Despite passing randomized tests during training, blind spots may occur where the agent’s policy fails. Results confirm that RL is a versatile, although complex, control engineering approach.
Does Parfit Establish Non-Reductionists Should Accept the Extreme Claim?
Authors: Ehring Douglas 
Published: December 2023

AbstractThe Non-Reductionist holds that personal identity is a matter in whole or in part of “further facts,” facts over and above those about psychological and physical continuity and connectedness. If Non-Reductionism is true, then it is possible for there to be “nonsymmetrical fission cases” in which there is nonsymmetry with respect to further facts such that the fissioner is identical with one of the fission products but not the other, even though there is symmetry along each branch with respect to non-further facts. If it is also true that the fissioner gets what matters with respect to the fission product to which the fissioner is not identical in those cases, it is possible for identity and what matters to come apart. If the Non-Reductionist is to hold fast to the importance of identity, she must demonstrate that the fissioner does not get what matters in survival with respect to the fission product to which he is not identical in cases of nonsymmetrical fission. One way to get this result would be to demonstrate that Non-Reductionism in and of itself has the implication that the fissioner does not get what matters with respect to the fission product to which he is not identical in the nonsymmetrical fission case. Parfit offers an argument that is meant to show that the Non-Reductionism qua Non-Reductionism has just this result. I outline Parfit’s argument and suggest that it does not work.
Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs
Authors: Komatsu Katsuko 
Published: December 2023

AbstractOur representative studies to achieve sustainable use of crude drugs and ensure their stable quality are introduced: comprehensive studies on genetic, chemical, and sometimes pharmacological diversity of Asian medicinal plants including Paeonia lactiflora, Glycyrrhiza uralensis, Ephedra spp., Saposhnikovia divaricata, and Curcuma spp., as well as their related crude drugs. (1) For peony root, after genetic and chemical diversity analysis of crude drug samples including white and red peony root in China, the value-added resources with quality similar to red peony root were explored among 61 horticultural P. lactiflora varieties, and two varieties were identified. In addition, an optimized post-harvest processing method, which resulted in high contents of the main active components in the produced root, was developed to promote cultivation and production of brand peony root. (2) Alternative resources of glycyrrhiza, ephedra herb and saposhnikovia root and rhizome of Japanese Pharmacopoeia grade were discovered in eastern Mongolia after field investigation and quality assessment comparing Mongolian plants with Chinese crude drugs. Simultaneously, suitable specimens and prospective regions for cultivation were proposed. (3) Because of the wide distribution and morphological similarities of Curcuma species, classification of some species is debated, which leads to confusion in the use of Curcuma crude drugs. Molecular analyses of the intron length polymorphism (ILP) markers in genes encoding diketide-CoA synthase (DCS) and curcumin synthase (CURS) and trnK sequences, combined with essential oils analysis, were demonstrated as useful for standardization of Curcuma crude drugs. The above studies, representing various facets, can be applied to other crude drugs.
On the analytic theory of isotropic ternary quadratic forms
Authors: Duke William , Schulze-Pillot Rainer 
Published: December 2023

AbstractA new local-global result about the primitive representations of zero by integral ternary quadratic forms is proven. By an extension of a result of Kneser (given in the Appendix), it yields a quantitative supplement to the Hasse principle on the number of automorphic orbits of primitive zeros of a genus of forms. One ingredient in its proof is an asymptotic formula for a count of the zeros of a given form in such an orbit.
Heavy Metals Assessment and Health Risk to Consumers of Two Commercial Fish Species from Polyculture Fishponds in El-Sharkia and Kafr El-Sheikh, Egypt: Physiological and Biochemical Study
Authors: Abbas Mahmoud Mahrous M. , EL-Sharkawy Salah M. , Mohamed Hassan R. , Elaraby Bassem E. , Shaban Walaa M. , Metwally Metwally G. , Farrag Diaa M. G. 
Published: December 2023

AbstractMetal pollution is a major environmental concern worldwide, especially in Egypt. The aquaculture industry uses widespread artificial feeds to stimulate fish production, leading to metal accumulation in the aquatic environment. Heavy metal concentrations (HMCs) in sediments, water, and tissues were studied to study the effect of pollution levels on heamatological, and biochemical, immunological aspects of farmed fish as well as on human health. Results declared that the HMC levels in the water and sediment were significantly different between El-Sharkia and Kafr El-Sheikh fishponds (T-test, p < 0.05). This was supported by the metal pollution index in the water and sediment, indicating that El-Sharkia fishponds (ES fishponds) were more contaminated than Kafr El-Sheikh fishponds (KES fishponds). Also, HMCs in fish tissues were significantly increased in fish cultivated in ES fishponds than in KES fishponds. Haematological, immunological, and biochemical alterations of Bolti (Oreochromis niloticus) and Topara (Chelon ramada) fish were significantly different within the different fish species as well as the different fishponds. From the human health perspective, the THQ-HMC and HI-HMC associated with the consumption of muscle suggest a safe non-carcinogenic risk to human health. In contrast, cadmium poses a cancer risk to children who consume the muscular tissue of Bolti fish from ES fishponds, which should be regarded as a warning sign based on data indices and a human health perspective. In order to minimise HMC pollution in the aquaculture sector, it is advisable to take possible assessments and carry out continuous monitoring considering international WHO/FAO assessments.
Mechanisms and risk factors of metabolic syndrome in children and adolescents
Authors: Codazzi Valentina , Frontino Giulio , Galimberti Luca , Giustina Andrea , Petrelli Alessandra 
Published: December 2023

AbstractMetabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity, elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The diagnostic criteria for MetS in adults are well-established, but there is currently no consensus on the definition in children and adolescents. The etiology of MetS is believed to involve a complex interplay between genetic predisposition and environmental factors. While genetic predisposition explains only a small part of MetS pathogenesis, modifiable environmental risk factors play a significant role. Factors such as maternal weight during pregnancy, children’s lifestyle, sedentariness, high-fat diet, fructose and branched-chain amino acid consumption, vitamin D deficiency, and sleep disturbances contribute to the development of MetS. Early identification and treatment of MetS in children and adolescents is crucial to prevent the development of chronic diseases later in life. In this review we discuss the latest research on factors contributing to the pathogenesis of MetS in children, focusing on non-modifiable and modifiable risk factors, including genetics, dysbiosis and chronic low-grade inflammation.
Integration of ultrasound-based radiomics with clinical features for predicting cervical lymph node metastasis in postoperative patients with differentiated thyroid carcinoma
Authors: Fan Fengjing , Li Fei , Wang Yixuan , Dai Zhengjun , Lin Yuyang , Liao Lin , Wang Bei , Sun Hongjun 
Published: December 2023

Abstract
Objective
The primary objective was to establish a radiomics model utilizing longitudinal +cross-sectional ultrasound (US) images of lymph nodes (LNs) to predict cervical lymph node metastasis (CLNM) following differentiated thyroid carcinoma (DTC) surgery.

Methods
A retrospective collection of 211 LNs from 211 postoperative DTC patients who underwent neck US with suspicious LN fine needle aspiration cytopathology findings at our institution was conducted between June 2021 and April 2023. Conventional US and clinicopathological information of patients were gathered. Based on the pathological results, patients were categorized into CLNM and non-CLNM groups. The database was randomly divided into a training cohort (n = 147) and a test cohort (n = 64) at a 7:3 ratio. The least absolute shrinkage and selection operator algorithm was applied to screen the most relevant radiomic features from the longitudinal + cross-sectional US images, and a radiomics model was constructed. Univariate and multivariate analyses were used to assess US and clinicopathological significance features. Subsequently, a combined model for predicting CLNM was constructed by integrating radiomics, conventional US, and clinicopathological features and presented as a nomogram.

Results
The area under the curves (AUCs) of the longitudinal + cross-sectional radiomics models were 0.846 and 0.801 in the training and test sets, respectively, outperforming the single longitudinal and cross-sectional models (p < 0.05). In the testing cohort, the AUC of the combined model in predicting CLNM was 0.901, surpassing that of the single US model (AUC, 0.731) and radiomics model (AUC, 0.801).

Conclusions
The US-based radiomics model exhibits the potential to accurately predict CLNM following DTC surgery, thereby enhancing diagnostic accuracy.
Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms
Authors: Wilken Silvana , Thevathasan Tharusan , Kamali Can , Guillot Adrien , Ihlow Jana , Fehrenbach Uli , Danyel Magdalena , Pratschke Johann , Tacke Frank , Krenzien Felix 
Published: December 2023

AbstractSimultaneous occurrence of benign hepatic lesions of different types is a sporadic phenomenon. To the best of our knowledge, we report the first clinical case of a syndrome with simultaneous manifestations of three different entities of benign liver tumors (hepatocellular adenoma, focal nodular hyperplasia and hemangioma) with a novel mutation detected in the liver adenoma and in the presence of a number of further extrahepatic organ neoplasms. Furthermore, we describe for the first time the presence of liver epithelial cells of hepatocytic phenotype expressing cytokeratin 7 (CK7) at the border of the adenoma. These findings may be important for explaining pathogenesis of benign as well as malignant tumors based on genetic and histopathological features.
The Additional Value of T1 Mapping in Cardiac Disease: State of the Art
Authors: Ascione Raffaele , De Giorgi Marco , Dell’Aversana Serena , Di Costanzo Giuseppe , Nappi Carmela , Imbriaco Massimo , Ponsiglione Andrea 
Published: December 2023

Abstract
Purpose of the Review
This paper delves into the emerging realm of T1 mapping, exploring recent innovations and their relevance across several cardiac diseases.

Recent Findings
T1 mapping with cardiovascular magnetic resonance (CMR) imaging has emerged as a valuable tool for cardiac disease evaluation, offering diagnostic, therapeutic, and prognostic insights. Tissue characterization using parametric mapping methods holds the promise of identifying and quantifying both focal and diffuse changes in myocardial structure, which cannot be adequately assessed through late gadolinium enhancement (LGE).

Summary
CMR imaging, particularly LGE, has enhanced cardiac tissue characterization. However, the detection of diffuse interstitial fibrosis remains challenging, necessitating the exploration of alternative techniques. T1 mapping could probably represent a game changer in the evaluation of diffuse and focal fibrosis in multiple cardiovascular conditions.
SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C
Authors: Moreno Rojas Andres F. , Bainto Emelia , Harvey Helen , Tremoulet Adriana H. , Burns Jane C. , Dummer Kirsten B. 
Published: December 2023

Abstract
Background
Recent infection with SARS‑CoV‑2 in children has been associated with multisystem inflammatory syndrome in children (MIS-C). SARS‑CoV‑2 has undergone different mutations. Few publications exist about specific variants and their correlation with the severity of MIS-C.

Methods
This was a single-center, retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March 2022. Local epidemiologic data, including viral genomic information, were obtained from public records. Demographics, clinical presentation, laboratory values, and outcomes were obtained from electronic medical records.

Results
The analysis included 104 pediatric patients. Four MIS-C waves were identified. Circulating variants in San Diego during the first wave included clades 20A to C. During the second wave, there were variants from clades 20A to C, 20G, 21C (Epsilon), 20I (Alpha), and 20J (Gamma). The third wave had Delta strains (clades 21A, 21I, and 21J), and the fourth had Omicron variants (clades 21K, 21L, and 22C). MIS-C presented with similar symptoms and laboratory findings across all waves. More patients were admitted to the pediatric intensive care unit (PICU) (74%) and required inotropic support (63%) during the second wave. None of the patients required mechanical circulatory support, and only two required invasive ventilatory support. There was no mortality.

Conclusions
The various strains of SARS-CoV-2 triggered MIS-C with differing severities, with the second wave having a more severe clinical course. Whether the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.
Effectiveness of embedded discontinuities technique in capturing geomechanical behavior in naturally fractured reservoirs
Authors: Maciel Bruno , Alvarez Leidy Laura , Belfort Nayara Torres , do Nascimento Guimarães Leonardo José , de Sá Beserra Leila Brunet 
Published: December 2023

AbstractThis paper highlights the efficacy of the finite element method with embedded strong discontinuities in modeling discontinuities in porous media, specifically in the geomechanical behavior of Naturally Fractured Reservoirs (NFRs). The approach considers hydromechanical coupling and offers low computational cost. NFRs account for a significant portion of global reserves, representing approximately 60% of global oil reserves and 40% of gas reserves. Given that flow in NFRs is more complex than in conventional reservoirs due to the presence of multiple fractures, it's crucial to understand how pressure variations or effective stress during operations impact fracture closure and permeability of these reservoirs. To analyze this behavior, numerical simulation results using the proposed method were compared, under different liquid pressure depletion values, with the approach proposed by Oda, which is commonly used in commercial software for calculating fracture permeability tensors. This approach was enriched with Barton's fracture closure formulation and updates on rock matrix porosity and permeability. Four simulations were conducted: Firstly, a hypothetical scenario consistent with Oda's assumptions, where fractures are interconnected and span the entire grid cell, to validate the numerical hydromechanical model; subsequently, three representative sections of a Brazilian pre-salt carbonate reservoir were selected. The study confirms the efficacy of the technique of embedded strong discontinuities in calculating equivalent permeabilities in NFRs, considering geomechanical effects, especially in cells with high fracture frequencies and intensities. Furthermore, the relevance of analyzing the geomechanical behavior in NFRs is emphasized.
Impact of stainless steel nano-alloys on biogas production rate: safe catalysts
Authors: El-Ansary Sara , Sliem Mahmoud A. , Badr Yehia , Soliman Wafaa 
Published: December 2023

Abstract
The feasibility of using nontoxic stainless steel colloidal solutions, synthesized by laser ablation in distilled water, for the production of biogas is examined in this paper. Given that their biodigesters are treated concurrently while taking into account the same experimental and environmental circumstances, certain results are compared with earlier work on NiFe2O4. As a result, the cumulative gas volume after the 50-days incubation period increased to 172 and 207% for NiFe2O4 and stainless steel nano-alloys, respectively. Additionally, the biogas flame and the information at hand are used to interpret the biological effect. The free Cr stainless steel colloidal solution yields an unexpected biogas volume of 207% of control, according to a recent discovery. However, the inhibition of Cr-based stainless steel digesters is attributed to the heat shock mechanism–based NIR resonance fluorescence property.

Novelty statement
Enhancement of biogas production rate from cow dung by 207%, in comparison to control, using nontoxic stainless steel nano-alloys free of Cr element synthesized by laser ablation of commercial targets in water. However, nano-alloys based on Cr element exhibit an inhibition effect due to a heat shock mechanism. Accordingly, stainless steel nano-alloys synthesized by laser ablation in water are eco-friendly and safe catalysts for applicants and users.

Graphical abstract
Navigating Interoperability in Disaster Management: Insights of Current Trends and Challenges in Saudi Arabia
Authors: Mani Zakaria Ahmed , Sultan Mohammed Ali Salem , Plummer Virginia , Goniewicz Krzysztof 
Published: December 2023

AbstractIn this rapid review, we critically scrutinize the disaster management infrastructure in Saudi Arabia, illuminating pivotal issues of interoperability, global cooperation, established procedures, community readiness, and the integration of cutting-edge technologies. Our exploration uncovers a significant convergence with international benchmarks, while pinpointing areas primed for enhancement. We recognize that continual commitments to infrastructural progression and technology adoption are indispensable. Moreover, we underscore the value of robust community involvement and cross-border collaborations as key factors in bolstering disaster response capabilities. Importantly, we spotlight the transformative influence of emerging technologies, such as artificial intelligence and the Internet of Things, in elevating the effectiveness of disaster management strategies. Our review champions in all-encompassing approach to disaster management, which entails harnessing innovative technologies, nurturing resilient communities, and promoting comprehensive disaster management strategies, encapsulating planning, preparedness, response, and recovery. As a result of our analysis, we provide actionable recommendations to advance Saudi Arabia’s disaster management framework. Our insights are timely and crucial, considering the escalating global focus on disaster response in the face of increasing disaster and humanitarian events.