bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overlapping pattern of the four individual components of dyslipidemia in adults: analysis of nationwide cross-sectional data
Authors: Zheng Wenxiao , Zhang Jiayue , Wang Shuting , Yang Zuyao 
Published: January 2024

Abstract
Background
Dyslipidemia, including abnormalities in any one of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) is a well-recognized risk factor for cardiovascular disease (CVD). However, among the currently available drug treatments, only the ones that lower LDL-C and consequently TC have proven effective in preventing CVD, suggesting that people with isolated high TG or low HDL-C would unlikely benefit from the treatments. The study aimed to investigate the overlapping pattern of the four individual components of dyslipidemia in adults, which could provide benchmark estimates on the contribution of each component to dyslipidemia prevalence and consequently on the proportion of potential beneficiaries of currently available, effective lipid-lowering drugs that are targeted at high LDL-C and high TC.
Methods
We included 7,822 participants aged ≥ 20 years, abnormal in any of the four lipid parameters, and not on lipid-lowering medications, from the National Health and Nutrition Examination Survey cycle 1999–2000 through cycle 2017–2018. Dyslipidemia was defined as presence of at least one of the following: TC ≥ 240 mg/dL, LDL-C ≥ 160 mg/dL, HDL-C < 40 mg/dL in males or < 50 mg/dL in females, and TG ≥ 200 mg/dL. The proportions of different combinations of them were calculated and then presented using area-proportional Euler plots.
Results
High TC, high LDL-C, high TG, and low HDL-C were seen in 32.8%, 28.1%, 26.7%, and 65.9% of the people with dyslipidemia, respectively. “High LDL-C or high TC”, “normal LDL-C, normal TC, but high TG”, and “normal LDL-C, normal TC, normal TG, but low HDL-C” (isolated low HDL-C) accounted for 37.5%, 18.3%, and 44.2% of dyslipidemia, respectively. “High LDL-C or high TC” accounted for 54% of dyslipidemia in those aged ≥ 60 years, while isolated low HDL-C was the most prevalent abnormality in almost all the other subgroups defined by gender, age and race.
Conclusions
Isolated low HDL-C, which was unlikely to benefit from currently available, effective drug treatments targeted at high LDL-C or TC, was the largest contributor to dyslipidemia prevalence. Potential beneficiaries of currently available drugs, i.e., those with high LDL-C or TC, accounted for 37.5% of all people with dyslipidemia.
Social-Ecological Landscape Sustainability in Ghana and Nigeria: An application of a DPSIR-SEL Framework
Authors: Atampugre Gerald , Igbadun Henry E. , Tilahun Seifu , Oke Adebayo , Mabhaudhi Tafadzwanashe , Olaleye A. O. , Cofie Olufunke 
Published: January 2024

Abstract

This study evaluates the Land Use and Land Cover (LULC) dynamics and water quality in the Mankran landscape in Ghana (case study-1) and the Doma-Rutu landscape in Nigeria (case study-2) using the Drivers Pressure State Impact Response (DPSIR) for social ecological landscape (SEL) assessment framework (DPSIR-SEL). In the Mankran landscape, between 2008 and 2018, there was a notable shift in land utilization: cash crop cultivation surged to 30% in 2015 before receding to 14.5% by 2018, while subsistence farming was reduced. Water quality analysis revealed deviations from World Health Organization (WHO) standards, with parameters such as Total Suspended Solids (TSS), Pb (lead), and As (arsenic) signaling potential contamination risks. Conversely, in the Doma-Rutu landscape of Nigeria, LULC changes from 2000 to 2022 manifest as expanding residential and agricultural areas and alterations in natural water bodies and vegetation. Water quality concerns have arisen with high levels of electrical conductivity, total dissolved solids, and salinity. Additionally, Focus Group Discussions (FGDs) in Nigeria illuminated the deep-rooted herder-farmer conflicts, constraining crop cultivation due to historical and environmental factors. The intertwined challenges in the Mankran landscape and Doma-Rutu landscape necessitate sustainable and inclusive resource management, adaptive land-use practices, and proactive measures to ensure water quality. Land use land cover (LULC) and water quality evaluations, informed by the DPSIR-SEL framework, underscore the pressing need for integrated and inclusive solutions to address evolving land-use challenges and safeguard water resources in the Mankran and Doma-Rutu landscapes.
Investigation of the Potential Mechanism of Compound Dragon's Blood Capsule against Myocardial Ischemia Based on Network Pharmacology
Authors: Su Xin , Xue Hongwei , Lou Yang , Lv Xinkai , Mi Xiao , Lu Juan , Chen Xi 
Published: January 2024

Background:
Dragon's blood is widely consumed in China, Vietnam and Laos to
promote blood circulation. A Compound Dragon's blood capsule (CDC) is a patented medicine
composed of dragon’s blood, notoginseng, and borneol. This combination is purported to stabilize
coronary heart disease and myocardial ischemia. However, the possible mechanisms and the
characterization of its drug targets’ relevance at the systemic level remain unclear.

Aim:
The present study aims to reveal the potential mechanisms of CDC’s anti-myocardial
ischemia effect

Materials and Methods:
The potential mechanisms were investigated by network pharmacology
and qRT-PCR was used to verify the expression levels of key genes of PI3k-Akt pathway.

Results:
S1PR2 and AGTR1 were the common targets, which involved 6 biological processes
annotated by KEGG and GO analysis. The qRT-PCR results showed a remarkable increase in
the expression of Pi3k, Pdk1, Akt, Mdm2, Bcl2, and mTOR. Results also showed a decline in the
expression of P53 and Casp3 after CDC intervention.

Conclusion:
CDC has a significant anti-myocardial ischemia effect through the PI3k/Akt pathway,
which demonstrates that CDC is a suitable adjuvant to treat CHD and provides a theoretical
basis for its further clinical application.
TOMM40 Correlates with Cholesterol and is Predictive of a Favorable Prognosis in Endometrial Carcinoma
Authors: Chen Yan , Luo Yi , Long Jinling , Liu Siyun , Zhao Linbeini , Chen Baishu , Mu Qiuyun 
Published: January 2024

Background:
A link between cholesterol and endometrial cancer has been established,
but current studies have been limited in their findings. We aimed to elucidate the causal relationship
between cholesterol and endometrial cancer and to find prognostic genes for endometrial
cancer.

Methods:
We first explored the causal relationship between total cholesterol and endometrial
cancer using two-sample Mendelian randomization and then obtained differential genes to screen
for prognosis-related genes in endometrial cancer. Then, we utilized pan-cancer analysis based
on RNA sequencing data to evaluate the expression pattern and immunological role of the Translocase
of Outer Mitochondrial Membrane 40 (TOMM40). Through multiple transcriptome datasets
and multi-omics in-depth analysis, we comprehensively explore the relationship of
TOMM40 expression with clinicopathologic characteristics, clinical outcomes and mutations in
endometrial cancer. Lastly, we systematically associated the TOMM40 with different cancers
from immunological properties from numerous perspectives, such as immune cell infiltration,
immune checkpoint inhibitors, immunotherapy, gene mutation load and microsatellite instability.

Results:
We found a negative association between cholesterol and endometrial cancer. A total of
78 genes were enriched by relevant single nucleotide polymorphisms (SNPs), of which 12 upregulated
genes and 5 downregulated genes in endometrial cancer. TOMM40 was found to be a
prognostic gene associated with endometrial cancer by prognostic analysis. TOMM40 was found
to be positively correlated with the infiltration of most immune cells and immunization checkpoints
in a subsequent study. Meanwhile, TOMM40 also was an oncogene in many cancer types.
High TOMM40 was associated with lower genome stability.

Conclusion:
The findings of our study indicate that the maintenance of normal total cholesterol
metabolism is associated with a decreased risk of developing endometrial cancer. Moreover,
TOMM40 may have potential as a prognostic indicator for endometrial cancer.
Synergistic Effect of Silver Nanoparticles with Antibiotics for Eradication
of Pathogenic Biofilms
Authors: Masadeh Majed M. , Al-Tal Zeinab , Khanfar Mai S. , Alzoubi Karem H. , Sabi Salsabeel H. , Masadeh Majd M. 
Published: January 2024

Background:
The increase in nosocomial multidrug resistance and biofilm-forming
bacterial infections led to the search for new alternative antimicrobial strategies other than traditional
antibiotics. Silver nanoparticles (AgNP) could be a viable treatment due to their wide
range of functions, rapid lethality, and minimal resistance potential. The primary aim of this
study is to prepare silver nanoparticles and explore their antibacterial activity against biofilms.

Methods:
AgNPs with specific physicochemical properties such as size, shape, and surface
chemistry were prepared using a chemical reduction technique, and then characterized by DLS,
SEM, and FTIR. The activity of AgNPs was tested alone and in combination with some antibiotics
against MDR Gram-negative and Gram-positive planktonic bacterial cells and their biofilms.
Finally, mammalian cell cytotoxicity and hemolytic activity were tested using VERO and human
erythrocytes.

Results:
The findings of this study illustrate the success of the chemical reduction method in
preparing AgNPs. Results showed that AgNPs have MIC values against planktonic organisms
ranging from 0.0625 to 0.125 mg/mL, with the greatest potency against gram-negative bacteria.
It also effectively destroyed biofilm-forming cells, with minimal biofilm eradication concentrations
(MBEC) ranging from 0.125 to 0.25 mg/ml. AgNPs also had lower toxicity profiles for the
MTT test when compared to hemolysis to erythrocytes. Synergistic effect was found between
AgNPs and certain antibiotics, where the MIC was dramatically reduced, down to less than
0.00195 mg/ml in some cases.

Conclusion:
The present findings encourage the development of alternative therapies with high
efficacy and low toxicity.
Late Presentation of Primary Oxalosis, Microcrystalline Arthropathy, and
Tumoral Calcinosis: A Case Report and a Literature Review
Authors: Mrabet Sanda , BenHmida Mohamed 
Published: January 2024

Background::
Primary hyperoxaluria consists of a group of inherited disorders with enzymatic
defects in the glyoxylate pathway, leading to decreased oxalate metabolism. The resulting
oxalic deposition is specifically responsible for kidney disease and joint disease. Neonatal oxalosis
is the most severe form of primary hyperoxia type 1, with the onset of end-stage renal disease
in childhood.

Case Presentation::
A 55-year-old hemodialysis man was referred to Nephrology because of inflammatory
polyarthralgia and periarticular swelling evolving for six months. He had been on hemodialysis
for six years for end-stage chronic renal failure, diagnosed at the same time as primary
hyperoxaluria. Radiological investigation showed a rugby jersey appearance on the lumbar spine,
budding calcium tone opacities next to large joints and clavicles, vascular calcifications and tumoral
calcinosis. The synovial fluid contained a few cells with polymorphic intracellular crystals. We
ruled out hyperparathyroidism, hypoparathyroidism, and related phosphocalcic disorders, and we
retained arthropathy and tumoral calcinosis secondary to primary hyperoxaliuria. The patient also
had congestive heart failure. Despite intensification of hemodialysis, he did not improve and died
at the age of 56 in the context of cachexia.

Conclusion::
This rare case documents the possible occurrence of late clinical presentation and
long survival in primary oxalosis with extra renal complications.
Exploring the Potential of Metformin in Mitigating Radiation-induced
Gastrointestinal and Hematopoietic System Injury in Rats After
Whole-body X-ray Radiation: An Experimental Study
Authors: Khodamoradi Ehsan , Rahmani Nafiseh , Rashidi Khodabakhsh , Najafi Masoud , Shahsavari Soodeh , Mohammadi Mohammad 
Published: January 2024

Background::
The modern world faces a growing concern about the possibility of
accidental radiation events. The Hematopoietic system is particularly vulnerable to radiationinduced
apoptosis, which can lead to death. Metformin, a drug used to treat diabetes, has been
shown to protect normal cells and tissues from the toxic effects of radiation. This study aimed to
evaluate the effectiveness of metformin in mitigating radiation injury to the gastrointestinal and
hematological systems of rats.

Materials and Methods:
The study involved 73 male rats. After total body irradiation with 7.5
Gy of X-rays, rats were treated with metformin. Seven days later, the rats were sacrificed and
blood samples were taken for evaluation.

Results::
The study found that metformin was not effective in mitigating radiation injury. The
histopathological assessment showed no significant changes in goblet cell injury, villi shortening,
inflammation, or mucous layer thickness. In terms of biochemical evaluation, metformin
did not significantly affect oxidative stress markers, but irradiation increased the mean MDA
level in the radiation group. The complete blood count revealed a significant decrease in WBC
and platelet, counts in the radiation group compared to the control group, but no significant difference
was found between the radiation and radiation + metformin groups.

Conclusion::
In conclusion, metformin may not be a good option for reducing radiation toxicity
after accidental exposure. Despite treatment, there was no improvement in platelet, white blood
cell, and lymphocyte counts, nor was there any decrease in oxidative stress. Further research is
needed to explore other potential treatments for radiation injury.
La migración rural-urbana como factor de cambio en la composición y manejo de solares mayas
Authors: Morales Rodríguez José Roberto , Aguilar Cordero Wilian de Jesús , Salazar Gómez Varela Carmen , García Gil José Gerardo 
Published: January 2024

El objetivo del estudio fue determinar si la migración modifica el manejo y la composición de la agrobiodiversidad en los solares, espacios donde la riqueza de especies asegura la provisión de bienes. En Dzoyaxché, Yucatán, se aplicó una entrevista semiestructurada y se realizó el inventario de la agrobiodiversidad a solares sin migrantes (SSM) y con migrantes (SCM). Los SSM registraron mayor diversidad florística y de fauna de traspatio; mientras que en SCM se registró una redistribución de las responsabilidades de manejo. En conclusión, la migración rural-urbana en Dzoyaxché es un factor que determina la agrobiodiversidad.
Transparencia, seguridad, empleo y participación electoral: su impacto en la recaudación municipal, Jalisco, México (2016-2018)
Authors: Alcantar López Cristian Omar 
Published: January 2024

Este artículo mide el impacto de la transparencia de información, seguridad de los habitantes, empleo municipal y participación electoral de los ciudadanos (variables independientes) en la recaudación municipal (variable dependiente). Esto deriva en la siguiente pregunta: ¿cuál es el impacto de la transparencia, seguridad de los habitantes, empleo municipal y participación electoral de los ciudadanos en la recaudación de los municipios de Jalisco con más de 5000 habitantes? La metodología fue de corte cuantitativa, mediante la aplicación del método de mínimos cuadrados ordinarios. Los resultados obtenidos indican que transparencia y seguridad inciden de manera positiva.
TRATAMENTO FOTOCATALÍTICO DE FÁRMACOS UTILIZANDO TIO2: UMA ANÁLISE SISTÊMICA DOS MECANISMOS DE DEGRADAÇÃO, REUSABILIDADE E VIABILIDADE DO PROCESSO EM ESCALA REAL
Authors: Nascimento Raqueline Caldas do , Rocha Elisângela Maria Rodrigues , Lucena Larissa Granjeiro , Cahino Arthur Marinho 
Published: January 2024

A contaminação das águas por compostos farmacêuticos em matrizes aquáticas é um problema recorrente em nossa sociedade. Um dos tratamentos mais conhecidos e utilizados para enfrentar essa questão é a fotocatálise heterogênea, capaz de destruir e mineralizar diversos contaminantes orgânicos. Por isso, o objetivo desta pesquisa foi realizar uma investigação das produções científicas acerca da fotocatálise heterogênea aplicada ao tratamento de contaminantes fármacos. Para tanto, utilizou-se o método da revisão sistemática em conjunto com uma análise sistêmica de um portfólio bibliográfico final (PBF) elaborado por meio do método construtivista PROKNOW-C. Dos 3.498 artigos selecionados, 33 foram escolhidos para comporem o PBF. As publicações analisadas abordavam as classes dos antibióticos, anti-hipertensivos, analgésicos e anti-inflamatórios e utilizavam o TiO2 como catalisador de referência. Observou-se que a maioria das pesquisas se concentrou no aprimoramento da fotocatálise de TiO2 por modificação com dopagem de metais e heterojunções para a formação de novos compósitos. A principal espécie reativa identificada no processo foi o radical hidroxila (•OH), ainda que sejam utilizados diferentes semicondutores, uma vez que os mecanismos de degradação se repetem durante a reação e podem ser intensificados pelas condições experimentais empregadas. A reusabilidade do catalisador em número de ciclos ocorreu no máximo até 5 vezes sem que houvesse perda de eficiência, sendo quatro a quantidade de vezes que alguns catalisadores obtiveram maior desempenho após a sua reutilização. Quanto ao uso em escala real, compreende-se que existe uma lacuna sobre as análises de desempenho dos fotocatalisadores utilizados em condições mais adversas e complexas.
Workability and durability analysis of waste based geopolymer concrete
Authors: Agashua Lucia Omolayo , Arum Chinwuba , Ayibiowu Bamitale Dorcas Oluyemi- , Ikumapayi Catherine Mayowa 
Published: January 2024

GPC as a promising material, started gaining momentous attention from the researchers and construction specialists because of its advantages in using by-products from agriculture and industries to replace cement thereby reducing greenhouse gas emission. Workability and durability tests were carried out, so as ascertain the efficiency of the rice husk ash and rice husk as sodium silicate and super plasticizer, for solving efflorescence problem known with geopolymer concrete. The factory-made sodium silicate was also used and compared with laboratory-produced, before addition of other geopolymer binders such as kaolin clay and fly ash. Brunauer-Emmett-Teller (BET) scrutiny that delivers quantitative data on the specific surface area as well as porosity dispersal of solid materials revealed that correlation coefficient of RHA (0.994) was higher than that of cement (0.991). Besides, RHA has higher surface area (250.023 m3/g) than the cement utilized which stood at 211.49 m3/g. Though the c constant of cement exceeds the RHA values, RHA can serve as good pozzolanic material and cement substitute. It is seen that the workability of laboratory-produced sodium silicate and superplasticizer geopolymer concrete was enhanced significantly compared to that of prior geopolymer systems. It is observed that the workability of the geopolymer concrete was considerably enhanced compared to that of orthodox geopolymeric systems, especially at 2.5% rice-husk created superplasticizer and higher content of laboratory-produced sodium silicate.
The Role of Witness and Victim Protection Agency for Imekko Tribe in Criminal Justice System in Sorong
Authors: Wahab Aznul Hidaya  
Published: January 2024

Keterangan saksi merupakan salah satu alat bukti yang sah dan sangat penting dalam setiap perkara pidana. Pentingnya hal tersebut dapat dilihat dari banyaknya kasus yang tidak dapat diselesaikan karena kurangnya alat bukti, terutama keterangan saksi. Ancaman kekerasan dan intimidasi yang sering diterima oleh saksi dan korban menjadi alasan utama mengapa banyak dari mereka yang tidak mau terlibat langsung dalam memberikan keterangan atas tindak pidana yang terjadi. Penelitian ini menggunakan metode yuridis empiris dengan teknik pengumpulan data melalui wawancara dan studi kepustakaan. Penelitian ini menyimpulkan bahwa implementasi kebijakan perlindungan saksi dan korban diawali dengan pemberlakuan Undang-Undang Nomor 31 Tahun 2014 tentang Perlindungan Saksi dan Korban. Dalam implementasinya, kebijakan perlindungan saksi dan korban di Indonesia didasarkan pada konsep perlindungan hukum terhadap saksi di Amerika Serikat sebagai model acuan. Meskipun telah ada regulasi yang mengatur tata cara pengajuan perlindungan saksi dan korban, namun masih terdapat beberapa kendala dalam perlindungan saksi dan korban. Beberapa kendala tersebut antara lain adalah posisi Lembaga Perlindungan Saksi dan Korban (LPSK) yang masih berpusat di ibu kota, sehingga akses dan pelayanan terhadap saksi dan korban di daerah terkadang kurang maksimal.

Translated with DeepL.com (free version)Witness statement is one of the legal evidence and is very important in every criminal case. Its importance can be seen from the number of cases that cannot be resolved due to lack of evidence, especially witness statement. Threats of violence and intimidation that are often received by witnesses and victims are the main reasons why many of them do not want to be directly involved in providing testimony on criminal acts that occur. This research uses empirical juridicial method with data collection techniques through interviews and literature studies. The research concluded that the implementation of witness and victim protection policy begins with the implementation of Law No. 31/2014 on Witness and Victim Protection. In its implementation, witness and victim protection policy in Indonesia is based on the concept of legal protection of witnesses in the United States as a model of reference. Although there are regulations governing the procedures for applying for witness and victim protection, there are still several obstacles to witness and victim protection. Some of these obstacles include the position of the Witness and Victim Protection Agency (LPSK) which is still centered in the capital city, so that access and services for witnesses and victims in the regions are sometimes less than optimal.
Partisipasi Anggota Kelompok Tani dalam Integrated Participatory Development And Management of Irrigation Program (IPDMIP) di Kecamatan Kalirejo Kabupaten Lampung Tengah
Authors: Tunggal Liels Abdi , Listiana Indah , Yanfika Helvi , Nurmayasari Indah 
Published: January 2024

Tujuan penelitian adalah untuk mengetahui partisipasi anggota kelompok tani dalam IPDMIP dan faktor - faktor yang berhubungan dengan partisipasi anggota kelompok tani dalam IPDMIP di Kecamatan Kalirejo Kabupaten Lampung Tengah. Penelitian ini menggunakan metode survey dengan responden pada penelitian ini berjumlah 25 petani. Penentuan lokasi penelitian ini dilakukan secara purposive (sengaja) dengan pertimbangan bahwa di Kecamatan Kalirejo merupakan salah satu kecamatan yang mendapatkan Integrated Partisipatory Development and Management of Irrigation Program (IPDMIP), selain itu kelompok tani di Kecamatan Kalirejo juga aktif sehinggal mendapatkan penghargaan kelompok tani unggul di IPDMIP. Waktu penelitian dilaksanakan pada bulan November 2021. Hasil penelitian tingkat partisipasi anggota kelompok tani dalam IPDMIP di Kecamatan Kalirejo Kabupaten Lampung Tengah pada tahap perencanaan termasuk dalam kategori sangat berpartisipasi. Partisipasi petani pada tahap pelaksanaan dan pemanfaatan hasil pada penelitian ini termasuk dalam kategori berpartisipasi. Partisipasi petani pada tahap evaluasi termasuk dalam kategori kurang berpartisipasi. Motivasi petani, peran penyuluh pertanian, kepemimpina ketua kelompok tani berhubungan dengan tingkat partisipasi anggota kelompok tani dalam IPDMIP, sedangkan umur petani, tingkat pendidikan formal, pengalaman usahatani, tingkat pengetahuan program, dan luas lahan tidak berhubungan dengan tingkat partisipasi anggota kelompok tani dalam IPDMIP di Kecamatan Kalirejo Kabupaten Lampung Tengah.

Kata kunci: Faktor, IPDMIP, Partisipasi, Kelompok tani