bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of virus-induced genome editing methods in Solanaceous crops
Authors: Lee Seo-Young , Kang Bomi , Venkatesh Jelli , Lee Joung-Ho , Lee Seyoung , Kim Jung-Min , Back Seungki , Kwon Jin-Kyung , Kang Byoung-Cheorl 
Published: November 2023

ABSTRACT
Genome editing (GE) using CRISPR/Cas systems has revolutionized plant mutagenesis. However, conventional transgene-mediated GE methods have limitations due to the time-consuming generation of stable transgenic lines expressing the Cas9/single guide RNA (sgRNA) module through tissue cultures. Virus-induced genome editing (VIGE) systems have been successfully employed in model plants, such as Arabidopsis thaliana and Nicotiana spp. In this study, we developed two VIGE methods for Solanaceous plants. First, we used the tobacco rattle virus (TRV) vector to deliver sgRNAs into a transgenic tomato (Solanum lycopersicum) line of cultivar Micro-Tom expressing Cas9. Second, we devised a transgene-free GE method based on a potato virus X (PVX) vector to deliver Cas9 and sgRNAs. We designed and cloned sgRNAs targeting Phytoene desaturase in the VIGE vectors and determined optimal conditions for VIGE. We evaluated VIGE efficiency through deep sequencing of the target gene after viral vector inoculation, detecting 40.3% and 36.5% mutation rates for TRV- and PVX-mediated GE, respectively. To improve editing efficiency, we applied a 37°C heat treatment, which increased the editing efficiency by 33% to 46% and 56% to 76% for TRV- and PVX-mediated VIGE, respectively. To obtain edited plants, we subjected inoculated cotyledons to tissue culture, yielding successful editing events. We also demonstrated that PVX-mediated GE can be applied to other Solanaceous crops, such as potato (Solanum tuberosum) and eggplant (Solanum melongena). These simple and highly efficient VIGE methods have great potential for generating genome-edited plants in Solanaceous crops.
Two transcription factors, AcREM14 and AcC3H1, enhance the resistance of kiwifruit Actinidia
chinensis var. chinensis to Pseudomonas syringae pv. actinidiae
Authors: Zhao Chao , Liu Wei , Zhang Yali , Li Yuanzhe , Ma Chao , Tian Runze , Li Rui , Li Mingjun , Huang Lili 
Published: November 2023

Abstract
Kiwifruit bacterial canker is a global disease caused by Pseudomonas syringae pv. actinidiae (Psa), which poses a major threat to kiwifruit production worldwide. Despite the economic importance of Actinidia chinensis var. chinensis, only a few resistant varieties have been identified to date. In this study, we screened 44 kiwifruit F1 hybrid lines derived from a cross between two A. chinensis var. chinensis lines and identified two offspring with distinct resistance to Psa: resistant offspring RH12 and susceptible offspring SH14. To identify traits associated with resistance, we performed a comparative transcriptomic analysis of these two lines. We identified several highly differentially expressed genes (DEGs) associated with flavonoid synthesis, pathogen interactions, and hormone signaling pathways, which play essential roles in disease resistance. Additionally, using weighted gene co-expression network analysis, we identified six core transcription factors. Moreover, qRT–PCR results demonstrated the high expression of AcC3H1 and AcREM14 in Psa-induced highly resistant hybrid lines. Ultimately, Overexpression of AcC3H1 and AcREM14 in kiwifruit enhanced disease resistance, and this was associated with upregulation of enzymatic activity and gene expression in the salicylic acid (SA) signaling pathway. Our study elucidates a molecular mechanism underlying disease resistance in kiwifruit and contributes to the advancement of research on kiwifruit breeding.
Entrants heterogeneity, pre-entry knowledge, and the target industry context: a taxonomy and a framework
Authors: Cattani Gino , Fontana Roberto , Malerba Franco 
Published: November 2023

AbstractThis paper advances a general and unified framework to explain the patterns of entry in an industry. The specificity of a type of entrant is examined based on the match between the entrant’s prior experience, in terms of knowledge endowment, and the target industry context. The knowledge endowment is analyzed by focusing on its content—market, technological, organizational, and scientific—and its generic and specific nature. The target industry context is examined by looking at four basic dimensions: the stage of development of the target industry (the time dimension); the specific technological regime and related innovation patterns (the technological dimension); the demand regime (the demand dimension); and the institutional regime (the institutional dimension). These dimensions moderate the matching between the knowledge endowment of the type of entrants and the features of the industrial contexts. Our newly proposed taxonomy offers a more systematic and nuanced explanation of how the complex relationship between pre-entry experience and knowledge, entrants and the chosen target industry evolves over time.
Research on the anti-aging efficacy of fermented lysate VHProbi® MixA as the functional skincare ingredient
Authors: Cui Hongchang , Feng Congrui , Guo Chaoqun , Bu Xinping , Li Xinping , Zhang Tao , Cheng Sidao , Duan Zhi 
Published: November 2023

Abstract

Aims
This study aimed to investigate the efficacy of a cream containing VHProbi® MixA for improving skin aging.

Methods and results
In vitro studies demonstrated that the lysate produced from Lacticaseibacillus paracasei E12 (E12) exhibited immunoregulatory effects in a 3D skin model, with significant reductions in levels of interleukin (IL)-1α, IL-1β, and IL-8 (P &lt; 0.05) compared with the control group. In addition, the lysate of E12 mitigated the hydrogen peroxide-induced mortality of 3D skin cells and enhanced the transepithelial electrical resistance to show significant differences in comparison with control (P &lt; 0.05), suggesting favorable antioxidant effects. The antioxidant capacity of the lysate of E12 was also confirmed using the Caenorhabditis elegans N2 model. C. elegans N2 fed the E12 strain showed a significantly higher % survival than those fed Escherichia coli OP50 (P &lt; 0.05). Subsequently, VHProbi® MixA was formulated using the fermented lysates of E12, Lactiplantibacillus plantarum E15, and Limosilactobacillus reuteri E18. In a clinical study to ascertain if a cream containing VHProbi® MixA could improve the skin aging trends, participants were asked to use the investigational products for 60 days, and six indicators, transepidermal water loss (TEWL), hydration, elasticity, wrinkles, skin texture (roughness), and pores were measured at baseline and the endpoint of the study. A self-evaluation questionnaire analysis was also provided. TEWL, wrinkles, skin texture, and thickness of pores decreased significantly after treatment with the cream for 60 days (P &lt; 0.01), whereas hydration and elasticity increased significantly (P &lt; 0.01), in comparison to the baseline measurements.

Conclusions
We hypothesize that the use of the cream containing VHProbi® MixA could be favorable for skin anti-aging management.
Non-original car spare parts and trade mark infringement: is there no room for referential use? The AG Opinion in C-334/22 Audi
Authors: Żelechowski Łukasz 
Published: November 2023

Abstract
In her Opinion in C-334/22 Audi, Advocate General (AG) Medina found that provisions of the EU trade mark law must be interpreted as meaning that an element placed on a non-original automotive spare part (radiator grille) for fitting the original mark of the car manufacturer would not constitute ‘use of a sign in the course of trade’. She ruled out, however, the possibility of relying on the referential use limitation in such circumstances. This gives rise to concerns that the AG’s Opinion construes the scope of the referential use limitation too narrowly. The author submits that the AUDI case, which is now to be decided by the Court of Justice of the European Union (CJEU), calls for attributing greater relevance to the catalogue of limitations and exceptions to exclusive trade mark rights, notably the referential use limitation. Moreover, a recalibration of the approach towards the 'honest practices' clause, which serves as a filter for all limitations and exceptions under EU trade mark law, is also needed in the context of non-original spare parts.
Race/Ethnicity Inequities in the Association Between Movement Behaviors and Suicidal Thoughts/Ideation Among Adolescents
Authors: Silva Diego Augusto Santos , Duncan Markus Joseph , Kuzik Nicholas , Tremblay Mark S 
Published: November 2023

Abstract

Objective
We aimed to analyze the associations between movement behaviors (physical activity, screen time, and sleep), independently and jointly, and suicidal thoughts/ideation among Brazilian adolescents according to race/ethnicity.

Methods
This cross-sectional study surveyed 4,081 adolescents aged 15–19 years (49.9% females) across all Brazilian geographic regions. Data were collected using a self-administered questionnaire. Within the sample, 31.0% (n = 1,264) self-reported as White and 69.0% (n = 2,817) as Black. Adolescents who declared one or more times/week suicidal thoughts/ideation were considered as a risk group. Accruing moderate-to-vigorous physical activity during leisure time, reduced recreational screen time, and good sleep quality were the exposures investigated. We evaluated both additive and multiplicative interactions between race/ethnicity and movement behaviors. Binary logistic regression was used to estimate the odds ratio (OR), marginal means effects, and 95% confidence intervals (95% CIs).

Results
Black adolescents who met 1 (OR: 0.34; [95% CI: 0.22–0.52]), 2 (OR: 0.17 [0.11–0.27]), or 3 (OR: 0.13 [0.07–0.26]), and White adolescents who met 1 (OR: 0.35 [0.21–0.57]), 2 (OR: 0.14 [0.08–0.26]), or 3 (OR: 0.11 [0.04–0.31]) of the movement behavior targets had lower odds of suicidal thoughts/ideation than Black adolescents who did not meet any of the movement behavior targets. Black adolescents who did not meet any of the movement behavior targets had higher suicidal thoughts/ideation odds than the other adolescent’s groups.

Conclusions
We identified an inverse association between meeting individuals and combinations of movement behavior targets with suicidal thoughts/ideation. Among Black adolescents who did not meet any targets, these associations were more evident.
Saving Oneself Through Labor: Disabled Workers and Social Welfare Production in Southwest China, 1956–65
Authors: Zhang Jinghong 
Published: November 2023

Abstract
This article examines the organization of social welfare production work (shehui fuli shengchan gongzuo) in China’s southwest Sichuan province from 1956 to 1965, with a focus on the marginalized experience of disabled workers during and after the Great Leap Forward Campaign (1958–62). Utilizing unexamined state archives, local gazetteers, and newspaper publications, the study traces how disabled workers were incorporated into or excluded from the campaign and their survival strategies after its derailment. During the Great Leap Forward, a campaign that aimed to rapidly industrialize China and accelerate developmental timelines, disabled workers were mobilized into collective production for the first time in the People’s Republic of China. When the industrial labor force needed to shrink, however, these once-mobilized disabled workers were marginalized and excluded from the state production system and instead resorted to heterodox forms of labor not officially recognized by the Communist state. The article argues that the tension between disabled workers and the Chinese Communist state, intensified by poor economic conditions, stemmed from the marginalization of disabled individuals with limited productivity in the state’s idealized vision of productive labor. By uncovering the interplay between disability, labor mobilization, and state ideology, this article contributes to a deeper understanding of the social and economic dynamics during the Great Leap Forward era.
SDSS-IV MaNGA: the role of the environment in AGN triggering
Authors: Rembold Sandro B , Riffel Rogério , Riffel Rogemar A , Storchi-Bergmann Thaisa , Schimoia Jaderson da S , Valk Greique A , Lorenzoni Vanessa , Ilha Gabriele S , da Costa Luiz N 
Published: November 2023

ABSTRACT
The large- and small-scale environments around optically-selected AGN host galaxies and a control sample of non-active galaxies in the MaNGA survey have been investigated in order to evaluate the importance of the environment in AGN triggering. Using the MaNGA integral field spectroscopy, we quantify non-circular motions of the ionized gas and detect an excess of radial gas motions in AGN hosts relative to control galaxies, not associated to AGN feedback and are most likely the result of tidal interactions, possibly associated with the triggering of the AGN. We find that the large-scale environments are similar for the AGN hosts and control galaxies in our sample and are biased towards lower large-scale densities and group virial masses, suggestive that the large-scale environment properties is only relevant to the AGN phenomenon in an indirect way, in the form, e.g. of the morphology-density relation. The small-scale environment, as measured by the frequency and luminosity of close neighbours, was also found to be similar for AGN and control galaxies. However, we find a correlation between the intensity of the non-circular gas motions in AGN hosts and the strength of the tidal field, while the control sample does not present such correlation. Also, AGN hosts with the most intense radial gas motions present larger tidal fields than their control galaxies. These findings indicate that at least a fraction of the AGN hosts in our sample have been triggered by tidal interactions with nearby galaxies.
LTBK-06. IMPACT OF VORASIDENIB TREATMENT ON MUTANT IDH1 OR IDH2 DIFFUSE GLIOMA TUMOR GROWTH RATE: RESULTS FROM THE RANDOMIZED, DOUBLE-BLIND, PHASE 3 INDIGO STUDY
Authors: Wen Patrick , Mellinghoff Ingo , van den Bent Martin , Blumenthal Deborah , Touat Mehdi , Peters Katherine , Clarke Jennifer , Mendez Joe , Yust-Katz Shlomit , Mason Warren , Ducray Francois , Umemura Yoshie , Nabors L Burt , Holdhoff Matthias , Hottinger Andreas , Arakawa Yoshiki , Sepúlveda Juan , Wick Wolfgang , Soffietti Riccardo , Perry James , Giglio Pierre , de la Fuente Macarena , Maher Elizabeth , Zhao Dan , Pandya Shuchi , Steelman Lori , Hassan Islam , Cloughesy Timothy , Ellingson Benjamin 
Published: November 2023

Abstract

INTRODUCTION
The INDIGO study (NCT04164901) showed that vorasidenib, an oral, brain-penetrant, dual inhibitor of mutant isocitrate dehydrogenase (mIDH) 1/2, significantly improved imaging-based progression-free survival and time-to-next-intervention compared with placebo in patients with grade 2 mIDH1/2 glioma previously treated with surgery only. Given the limitations of traditional bi-dimensional measurements, evaluating volumetry and tumor growth rate (TGR) is an additional method of measuring treatment effect in these diffuse growing tumors.

METHODS
Magnetic resonance imaging (MRI) scans were performed at baseline and every 12 weeks on-treatment; up to three pre-treatment MRI scans were requested when available. Tumor volumes were derived per blinded independent review committee using a semi-automated approach. TGR was defined as percentage change in tumor volume every 6 months. Patients with evaluable baseline and ≥ 1 MRI during the corresponding period were included in the analysis. The difference in TGR in each arm was assessed by slope of tumor growth over time using a linear mixed model.

RESULTS
331 patients were randomized to vorasidenib (n=168) or placebo (n=163). Median follow-up was 14.2 months. On-treatment TGR was −2.5% (95% CI, −4.7, −0.2) with vorasidenib (n=167) and 13.9% (95% CI, 11.1, 16.8) with placebo (n=161). In patients with available imaging data, TGR pre- and post-treatment with vorasidenib (n=56) was 13.2% (95% CI, 10.3, 16.3) and −3.3% (95% CI, −5.2, −1.2), respectively, while placebo (n=67) was 18.3% (95% CI, 15.0, 21.7) and 12.2% (95% CI, 9.5, 14.9), respectively. In patients who crossed over from placebo with available imaging data (n=38), TGR pre- and post-crossover was 22.4% (95% CI, 15.7, 29.4) and 5.2% (95% CI, −3.8, 15.0), respectively.

CONCLUSIONS
Tumor growth was observed in patients with mIDH1/2 gliomas before receiving vorasidenib or placebo. Treatment with vorasidenib reduced the TGR and shrunk tumor volume, whereas continued growth in tumor volume was observed in patients receiving placebo.
Berlin Klezmer and Urban Scenes
Authors: Alexander Phil 
Published: November 2023

Abstract
This chapter considers klezmer music’s changing social role: from the ritual musical expression of distinct ethnic and geographic nineteenth- and early twentieth-century Ashkenazic Jewish communities in eastern Europe and subsequently the United States, to a looser twenty-first-century articulation of musical connectivity, as expressed within multiple local scenes. It focuses particularly on developments in Berlin over the past three decades, during which time the city has hosted the busiest and most dynamic klezmer scenes outside of North America. The analysis follows a narrative that has moved from committed but isolated pioneers, through a rapid post-reunification take-up (initially by a majority of non-Jews), to a contemporary sense of community as seen in the work of a group of younger, international musicians, some of whom have also brought a renewed emphasis to the Jewishness of klezmer. The chapter argues that the city and its cosmopolitanism facilitate the conjuncture of local scene and transnational community.
Jewish Music and Totalitarianism in the Post-Stalinist Soviet Union
Authors: Nemtsov Jascha 
Published: November 2023

Abstract
The years 1953 through the 1970s in the Soviet Union have been called the era of the “Jews of silence.” And yet through various types of musical activities, certain parts of the Jewish population in the USSR were able to maintain a collective cultural identity in the public sphere. Captured as a musical community, this collectivity also extended to non-Jewish composers, musicians, and audiences. As such it thematicized, performed, represented, and received Jewishness, through Yiddish theater and songs, art music, and popular music. Concerts and works conceived for the Soviet stages demonstrate that Jewishness mattered, with music taking on new symbolism and becoming imbued with new meaning. This chapter focuses on the presence (and absence) of Jewish music in the public sphere, specifically in the concert hall and other stages in the post-Stalinist Soviet Union.
Postcustodialism in the Jewish Music Archive
Authors: Toltz Joseph 
Published: November 2023

Abstract
This chapter addresses the question of how to approach Jewish music in archives at a time when postcustodialism is seen as an ethical imperative to address the imbalance of power relations between non-Indigenous custodians, scholars, and traditional owners of culture. It does so through the lens of two case studies—the Australian Archive of Jewish Music at Monash University in Melbourne, and the United States Holocaust Memorial Museum in Washington, DC, and its music collections. Is postcustodialism a relevant concept for the Jewish music archive? In a world where the residuals of colonialism continue to have real impacts (especially for First Nations peoples), it is imperative for scholars of Jewish music working in archives to consider collaboration, care, custody, and control as factors mediating this material, and to emphasize the necessity of such a process for this material as we transition from an age of witness to an age of memory.
“Ferramonti We Do Not Forget”
Authors: Del Zoppo Silvia 
Published: November 2023

Abstract
In November 1938 fascist Italy began to promulgate a set of laws, known as leggi razziali, which enforced racial discrimination for the first time since the foundation of the Kingdom of Italy. Their effect on Jews cannot be overstated, and many left the country. In parallel, Italy began to create concentration camps, where mostly foreign Jews were imprisoned. One of them is Ferramonti di Tarsia in Calabria, which from 1940 to 1943 served as a concentration camp, and from liberation to December 1945 as a Displaced Persons camp. The musical activities in the camp during these two distinct phases are examined with a focus on two Hanukkah celebrations. During the first the prisoners emphasized their Jewishness through holiday-appropriate songs in Hebrew and German, while during the second, they deemphasized the same through the performance of largely European canonical repertoires, possibly preparing themselves for a return to their professions in the public institutions they had worked for prior to 1938. Ultimately, a third Ferramonti surfaces, an “imaginary,” transgenerational community consisting of both “insiders” and “outsiders,” who share the collective ritual of zekher. As such, the site of Ferramonti has hosted symbolic communities, past and present, each uniquely dealing with memory.
Land, Voice, Nation
Authors: Elbaz Vanessa Paloma 
Published: November 2023

Abstract
This chapter addresses the musically entangled histories of Al-Andalus, Sepharad, and North Africa, which are informing current political and musical discourse in Spain and Morocco, and their relationship to land and nation. Since the early 2000s, the performance of Mediterraneanism and peaceful coexistence through music has coalesced historical repertoires and contemporary politics, drawing memory, myth, music, diplomacy, and Judaism into continuous relationship. Two case studies—one being Ana Alcaide, a Spanish performer of Sephardic repertoires; the other the Kinor David Maroc ensemble from Morocco that focuses on Jewish liturgical poetry and Judeo-Andalusian repertoire—demonstrate how the Jewish relationship to adamah (earth) and its fellow arets (land) vis-à-vis voice, fertility, and burial counterpoints the tripartite relationship of Jews to local specificities, to the diverse nation in Spain and Morocco, and to their simultaneous belonging to a larger Jewish polity.
The role of histone acetylation in transcriptional regulation and seed development
Authors: Chen Yan , Guo Peiguo , Dong Zhicheng 
Published: November 2023

Abstract
Histone acetylation is highly conserved across eukaryotes and has been linked to gene activation since its discovery nearly 60 years ago. Over the past decades, histone acetylation has been evidenced to play crucial roles in plant development and response to various environmental cues. Emerging data indicate that histone acetylation is one of the defining features of “open chromatin,” while the role of histone acetylation in transcription remains controversial. In this review, we briefly describe the discovery of histone acetylation, the mechanism of histone acetylation regulating transcription in yeast and mammals, and summarize the research progress of plant histone acetylation. Furthermore, we also emphasize the effect of histone acetylation on seed development and its potential use in plant breeding. A comprehensive knowledge of histone acetylation might provide new and more flexible research perspectives to enhance crop yield and stress resistance.