bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interplay between driveline infection, vessel wall inflammation, cerebrovascular events and mortality in patients with left ventricular assist device
Authors: Hupe Juliane , Worthmann Hans , Ravenberg Kim K. , Grosse Gerrit M. , Ernst Johanna , Haverich Axel , Bengel Frank M. , Weissenborn Karin , Schmitto Jan D. , Hanke Jasmin S. , Derlin Thorsten , Gabriel Maria M. 
Published: October 2023

AbstractIn patients with left ventricular assist device (LVAD), infections and thrombotic events represent severe complications. We investigated device-specific local and systemic inflammation and its impact on cerebrovascular events (CVE) and mortality. In 118 LVAD patients referred for 18F-FDG-PET/CT, metabolic activity of LVAD components, thoracic aortic wall, lymphoid and hematopoietic organs, was quantified and correlated with clinical characteristics, laboratory findings, and outcome. Driveline infection was detected in 92/118 (78%) patients by 18F-FDG-PET/CT. Activity at the driveline entry site was associated with increased signals in aortic wall (r = 0.32, p < 0.001), spleen (r = 0.20, p = 0.03) and bone marrow (r = 0.20, p = 0.03), indicating systemic interactions. Multivariable analysis revealed independent associations of aortic wall activity with activity of spleen (β = 0.43, 95% CI 0.18–0.68, p < 0.001) and driveline entry site (β = 0.04, 95% CI 0.01–0.06, p = 0.001). Twenty-two (19%) patients suffered CVE after PET/CT. In a binary logistic regression analysis metabolic activity at the driveline entry site missed the level of significance as an influencing factor for CVE after adjusting for anticoagulation (OR = 1.16, 95% CI 1–1.33, p = 0.05). Metabolic activity of the subcutaneous driveline (OR = 1.13, 95% CI 1.02–1.24, p = 0.016) emerged as independent risk factor for mortality. Molecular imaging revealed systemic inflammatory interplay between thoracic aorta, hematopoietic organs, and infected device components in LVAD patients, the latter predicting CVE and mortality.
Robots at your doorstep: acceptance of near-future technologies for automated parcel delivery
Authors: Said Maher , Aeschliman Spencer , Stathopoulos Amanda 
Published: October 2023

AbstractThe logistics and delivery industry is undergoing a technology-driven transformation, with robotics, drones, and autonomous vehicles expected to play a key role in meeting the growing challenges of last-mile delivery. To understand the public acceptability of automated parcel delivery options, this U.S. study explores customer preferences for four innovations: autonomous vehicles, aerial drones, sidewalk robots, and bipedal robots. We use an Integrated Nested Choice and Correlated Latent Variable (INCLV) model to reveal substitution effects among automated delivery modes in a sample of U.S. respondents. The study finds that acceptance of automated delivery modes is strongly tied to shipment price and time, underscoring the importance of careful planning and incentives to maximize the trialability of innovative logistics options. Older individuals and those with concerns about package handling exhibit a lower preference for automated modes, while individuals with higher education and technology affinity exhibit greater acceptance. These findings provide valuable insights for logistics companies and retailers looking to introduce automation technologies in their last-mile delivery operations, emphasizing the need to tailor marketing and communication strategies to meet customer preferences. Additionally, providing information about appropriate package handling by automated technologies may alleviate concerns and increase the acceptance of these modes among all customer groups.
A Korean emotion-factor dataset for extracting emotion and factors in Korean conversations
Authors: Yoo SoYeop , Lee HaYoung , Song JeIn , Jeong OkRan 
Published: October 2023

AbstractHumans express their emotions in various ways, such as through facial expressions and voices. In particular, emotions are directly expressed or indirectly implied in the text of utterance. Research on the technology to identify emotions included in human speech and generate utterances is being conducted in conversational artificial intelligence technology. Despite the importance of recognizing the factors of previously generated emotions to generate emotion-based utterances, most of the existing datasets only provide the classification of emotions in text and utterances. In addition, in the case of Korean datasets, the classification of emotions is not diverse, and it is mainly biased toward negative emotion classification. In this paper, we propose KEmoFact, a Korean emotion-factor dataset for extracting emotion and factors in Korean conversations. We also define two tasks for the KEmoFact dataset, EFE (Emotion Factor Extraction) and EFPE (Emotion-Factor Pair Extraction), and propose baseline models for the tasks. We contribute to the study of conversational artificial intelligence, especially in Korean, one of the low-resource languages, by proposing the KEmoFact dataset and suggesting baseline models for two tasks.
An analysis of variants in TARDBP in the Korean population with amyotrophic lateral sclerosis: comparison with previous data
Authors: Sung Wonjae , Kim Jin-Ah , Kim Yong Sung , Park Jinseok , Oh Ki-Wook , Sung Jung-Joon , Ki Chang-Seok , Kim Young-Eun , Kim Seung Hyun 
Published: November 2023

AbstractThe TARDBP gene variant is a known major cause of amyotrophic lateral sclerosis (ALS), with limited reports of Korean patients with ALS harboring the variants in TARDBP. This large cohort study introduces four ALS patients who share the p.M337V variant of the TARDBP, allowing for an investigation of clinical characteristics and prognosis by analyzing previously reported cases with the same variant. From November 2014 to August 2022, participants were recruited from two tertiary hospitals in Seoul, Korea. Clinical characteristics of patients diagnosed with ALS carrying the variant in TARDBP were evaluated. Previous articles demonstrating subjects’ characteristics were reviewed. Four patients were identified with the pathogenic missense variant (c.1009A>G; p.M337V) in the TARDBP. The mean age of onset was 55 years old, and none of the patients showed severe cognitive impairment. Sixty-three patients carrying the p.M337V variant in TARDBP from this study and previous reports delineated young age of onset (51.6 years), high frequency of bulbar onset patients (61.9%), and low comorbidity of frontotemporal dementia. This study reveals the presence of pathogenic variant of TARDBP in Korea and emphasizes the importance of genetic screening of the TARDBP gene, in diagnosing ALS and evaluating prognosis among familial and simplex ALS patients in Korea.
Long distance laser filamentation using Yb:YAG kHz laser
Authors: Walch Pierre , Mahieu Benoît , Moreno Victor , Produit Thomas , Andral Ugo , André Yves-Bernard , Bizet Laurent , Lozano Magali , Herkommer Clemens , Moret Michel , Jung Robert , Bessing Robert , Klingebiel Sandro , Bertho Yann , Metzger Thomas , Mysyrowicz André , Wolf Jean-Pierre , Kasparian Jérôme , Houard Aurélien 
Published: October 2023

AbstractIn the framework of the Laser Lightning Rod project, whose aim is to show that laser-induced filaments can guide lightning discharges over considerable distances, we study over a distance of 140 m the filaments created by a laser system with J-range pulses of 1 ps duration at 1 kHz repetition rate. We investigate the spatial evolution of the multiple filamentation regime using the fundamental beam at 1030 nm or using combination with the second and third harmonics. The measurements were made using both a collimated beam and a loosely focused beam.
The synergy of the XPO1 inhibitors combined with the BET inhibitor INCB057643 in high-grade B-cell lymphoma via downregulation of MYC expression
Authors: Deng Manman , Tan Jinshui , Fan Ziying , Pham Lan V. , Zhu Feng , Fang Xiaosheng , Zhao Haijun , Young Kenh , Xu Bing 
Published: October 2023

AbstractHigh grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH) represents an uncommon B-cell lymphoma (BCL) with aggressive clinical courses and poor prognosis. Despite revolutionary therapeutic advances in BCL, there has been limited treatment progress in HGBCL-DH, thus necessitating additional therapeutic strategies for HGBCL-DH. This study demonstrated that the BET antagonist INCB057643 synergized with the XPO1 inhibitors (selinexor and eltanexor) to decrease cell viability and increase cell apoptosis in HGBCL-DH cells with or without TP53 mutations. As anticipated, the combined treatment of INCB057643 with selinexor slowed tumor growth and reduced the tumor burden in TP53-mutated HGBCL-DH xenografts. Mechanistically, MYC functional inhibition was a potential molecular mechanism underlying the synergy of the combined INCB057643 and selinexor treatment in HGBCL-DH cells independent of TP53 mutation status. In TP53 mutated HGBCL-DH cells, inducing DNA damage and impairing the DNA damage response (DDR) were involved in the therapeutic interaction of the combined regimen. In TP53 wild-type cells, the molecular mechanism was linked with upregulation of p53 levels and activation of its targeted pathways, rather than dysregulation of the DDR. Collectively, we might provide a potential promising combination therapy regimen for the management of HGBCL-DH. Clinical evaluations are warranted to confirm this conclusion.
Cross-linked multifunctional binder in situ tuning solid electrolyte interface for silicon anodes in lithium ion batteries
Authors: Lou Xiaofei , Zhang Yuanyuan , Zhao Li , Zhang Teng , Zhang Hui 
Published: October 2023

AbstractSilicon is considered as the most promising anode material for high performance lithium-ion batteries due to its high theoretical specific capacity and low working potential. However, severe volume expansion problems existing during the process of (de)intercalation which seriously hinders its commercial progress. Binder can firmly adhere silicon and conductive agent to the current collector to maintain the integrity of the electrode structure, thereby effectively alleviating the silicon volume expansion and realizing lithium-ion batteries with high electrochemical performance. In this paper, citric acid (CA) and carboxymethyl cellulose (CMC) are adopted to construct a covalently crosslinked CA@CMC binder by an easy-to-scale-up esterification treatment. The Si@CA@CMC-1 electrode material shows an impressive initial coulombic efficiency (ICE) at 82.1% and after 510 cycles at 0.5 A/g, its specific capacity is still higher than commercial graphite. The excellent electrochemical performance of Si@CA@CMC-1 can be attributed to the ester bonds formed among CA@CMC binder and silicon particles. Importantly, by decoupling in situ EIS combining XPS at different cycles, it can be further proved that the CA@CMC binder can tune the component of SEI which provide a new-route to optimize the performance of silicon.
Lipidome and metabolome analyses reveal metabolic alterations associated with MCF-7 apoptosis upon 4-hydroxytamoxifen treatment
Authors: Nishimoto Kazuki , Okahashi Nobuyuki , Maruyama Masaharu , Izumi Yoshihiro , Nakatani Kohta , Ito Yuki , Iida Junko , Bamba Takeshi , Matsuda Fumio 
Published: October 2023

Abstract4-hydroxytamoxifen (OHT) is an anti-cancer drug that induces apoptosis in breast cancer cells. Although changes in lipid levels and mitochondrial respiration have been observed in OHT-treated cells, the overall mechanisms underlying these metabolic alterations are poorly understood. In this study, time-series metabolomics and lipidomics were used to analyze the changes in metabolic profiles induced by OHT treatment in the MCF-7 human breast cancer cell line. Lipidomic and metabolomic analyses revealed increases in ceramide, diacylglycerol and triacylglycerol, and decreases in citrate, respectively. Gene expression analyses revealed increased expression of ATP-dependent citrate lyase (ACLY) and subsequent fatty acid biosynthetic enzymes, suggesting that OHT-treated MCF-7 cells activate citrate-to-lipid metabolism. The significance of the observed metabolic changes was evaluated by co-treating MCF-7 cells with OHT and ACLY or a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor. Co-treatment ameliorated cell death and reduced mitochondrial membrane potential compared to that in OHT treatment alone. The inhibition of cell death by co-treatment with an ACLY inhibitor has been observed in other breast cancer cell lines. These results suggest that citrate-to-lipid metabolism is critical for OHT-induced cell death in breast cancer cell lines.
Influence of macular pigment on the sensitivity to discomfort glare from daylight
Authors: Jain Sneha , Wienold Jan , Eandi Chiara , Gisselbaek Sara , Kawasaki Aki , Andersen Marilyne 
Published: October 2023

AbstractUnderstanding the factors that influence the human perception of glare is necessary to properly address glare risks in buildings and achieve comfortable visual environments, especially in the workplace. Yet large inter-individual variabilities in glare perception remain unexplained and thus uncovered by the current empirical glare models. We hypothesize that this variability has an origin in the human retina, in particular in the density of macular pigments present in its central area, which varies between individuals. Macular pigments are known to absorb blue light and attenuate chromatic aberration, thus reducing light scatter. This study presents the outcomes of the first experiment ever conducted in a daylit office environment, in which glare sensitivity and macular pigment density were measured and compared for 110 young healthy individuals, along with other ocular parameters. The participants were exposed to different glare conditions induced by the sun filtered through either color-neutral or blue-colored glazing. In neutral daylight conditions with sun disc in the near periphery, neither macular pigment nor any other investigated ocular factors have an impact on discomfort glare perception whereas glare perception in conditions with the blue-colored sun disc in the near periphery was found to be correlated with macular pigment optical density.
Patient-Reported Outcomes (PROs) 3 und 6 Monate nach pneumologischer
Post-COVID-Rehabilitation
Authors: Hayden Markus C. , Schuler Michael , Limbach Matthias , Schwarzl Gabriele , Stenzel Nikola , Nowak Dennis , Schultz Konrad 
Published: November 2023

Zusammenfassung
Ziel der Studie  Wenn teilhaberelevante COVID-19-Krankheitsfolgen
auch die Atmungsorgane (mit-)betreffen, wird in nationalen und internationalen
Leitlinien eine pneumologische Rehabilitation (PR) empfohlen. Bisher liegen
jedoch aus Deutschland keine Studien über den Verlauf nach PR vor,
ebenso wenig wie über mögliche Verlaufsunterschiede zwischen den
beiden Long-Covid-Subgruppen
„Fortwährend-symptomatische-COVID-19“ und
“Post-COVID-Syndrom” (PCS).
Methodik  In einer
prospektiven Beobachtungsstudie wurden Patient-Reported Outcomes (PROs)
bezüglich Belastungsdyspnoe, Lebensqualität, Schmerz, Fatigue,
Depressivität und Angst zu PR-Beginn (T1), PR-Ende (T2) sowie nach 3
(T3) und 6 Monaten (T4) erfasst. Die statistische Auswertung erfolgte mittels
latenter Differenzenmodelle.
Ergebnisse  Es wurden 224
Rehabilitanden (MAlter=54,4; SDAlter=10,4;
42,0% weiblich) in die Studie eingeschlossen. Während der PR
verbesserten sich alle PROs signifikant. Nach der PR blieben die Verbesserungen
entweder mit großer Prä-Post-Effektstärke erhalten
(Belastungsdyspnoe, Lebensqualität), verringerten sich leichtgradig auf
kleine Prä-Post-Effektstärken (Depressivität, Fatigue)
oder reduzierten sich auf Ausgangsniveau (Angst, Schmerzen). PCS-Patienten
hatten zu T1 stärkere Belastungen in Depressivität, Fatigue und
Schmerzen, unterschieden sich aber nicht in den Verläufen. Indikatoren
der Schwere der vorausgegangenen akuten COVID-Phase (Sauerstofftherapie,
Behandlung auf Intensivstation, Beatmung) waren zu T1 mit höheren
Belastungen in Depressivität, Fatigue und Schmerzen assoziiert, aber
nicht mit den Verläufen während und nach der PR. Patientinnen
zeigten hingegen sowohl zu T1 höhere Belastungen in
Depressivität und Fatigue als auch höhere
Prä-Post-Effekte als männliche Patienten.

Schlussfolgerung  Verbesserungen in den PROs traten in beiden
Subgruppen nur während der PR, nicht jedoch im Nachbeobachtungszeitraum
auf. Dies legt nahe, dass die Veränderungen nicht durch den
natürlichen Heilungsverlauf, sondern zumindest teilweise durch die PR
bedingt sind. Überdies legen die Ergebnisse nahe, dass beide
Patientengruppen von einer PR profitieren können. Verbesserungen
hinsichtlich Belastungsdyspnoe und Lebensqualität sowie in einem
reduzierten Ausmaß auch hinsichtlich Depressivität und Fatigue
persistierten bis 6 Monate nach der PR, allerdings nicht hinsichtlich Schmerzen
und Ängstlichkeit. Um diese Effekte aufrechtzuerhalten sind
möglicherweise zusätzliche multimodale Interventionen
erforderlich.
Enantioselective Sulfonation of Enones with Sulfinates by Thiourea/Tertiary-Amine Catalysis
Authors: Li Guang-xun , Zhao Jin-zhong , Wang Si-fan , Yan Ming , Shi Jin-yi 
Published: November 2023

AbstractChiral γ-keto sulfones are significant structures in both organic synthesis and pharmaceutical chemistry. Although there are many choices for obtaining racemic forms, only a few enantioselective methods have been reported. We have developed a simple way for obtaining chiral γ-keto sulfones in moderate yields and moderate enantiomeric ratios. Readily available sulfinates were directly used as substrates that could be converted into sulfinic acids by treatment with boric acid. The bifunctional catalyst forms a chiral ion pair with the sulfinic acid and controls the enantioselectivity of the sulfonation through hydrogen bonding.
Construction of Bibenzothiophenes through Oxidative C–H Cyclization with 1,3-Diynes
Authors: Yang Yudong , Chen Jingyi , Lei Tao , Wan Danyang 
Published: November 2023

AbstractThe development of concise and efficient methods to construct bithiophene derivatives is an appealing task in the fields of organic chemistry and organic functional materials. Herein, we summarize our recent efforts towards the development of catalytic oxidative C–H cyclization reactions of thiophenol derivatives with 1,3-diynes, which provides a straightforward and effective synthetic approach to both symmetrical and nonsymmetrical 3,3′-bibenzothiophenes. This work is expected to stimulate the application of catalytic oxidative C–H annulation of aromatics with 1,3-diynes for the exploitation of organic functional materials.
Clinical Features and Determinants of Coronary Artery Dilatation in Pediatric Patients with Complete and Incomplete Kawasaki Disease: A Single-Center Experience Over 15 Years in Hubei, China
Authors: Deng You-ping , Zan Yu-xing , Wang Xia , Xia Qiu , Liu Pin , Xiong Hai-rong , Zhao Dong-chi 
Published: October 2023

Abstract
Objective This study is aimed to elucidate age-associated clinical and echocardiography-defined coronary artery (CA) abnormalities features and to identify independent determinants of CA dilatation in pediatric patients with complete Kawasaki disease (cKD) and incomplete KD (iKD) over 15 years in a tertiary hospital in China.
Methods This study comprised 241 patients with KD hospitalized in the pediatric department between 2003 and 2018. Patients were divided into three groups according to age at diagnosis: ≤12, 13 to 35, and ≥36 months.
Results A total of 167 (69.3%) patients were defined as cKD (aged 24 months, male 60.5%) and 74 (30.7%) patients as iKD (aged 18 months, male 59.5%). The prevalence of cervical lymphadenopathy significantly increased with age in both cKD and iKD patients. In iKD patients, the prevalence of rash significantly decreased with age. CA dilatation most frequently occurred in patients with cKD and iKD aged ≤12 months. The absence of conjunctivitis or oral changes and higher serum creatinine levels were independent determinants of CA dilatation in KD patients aged ≤12 months, regardless of age, sex, and the type of KD.
Conclusion Present study underlines the age-stratified disease characteristics, and the factors associated with CA dilatation in cKD and iKD patients. The absence of conjunctivitis or oral changes, higher serum creatinine levels, and mycoplasma, cytomegalovirus, and adenovirus infections might be associated with an increased risk of CA dilatation in KD patients. These findings provide additional hints for pediatricians in the early diagnosis and treatment of KD, especially for individual medical care of cKD and iKD patients in different age groups.
Openness and age influence cognitive progression: a longitudinal study
Authors: Merlin Silvia Stahl , Brucki Sonia Maria Dozzi 
Published: October 2023

Abstract
Background Some psychological and personality characteristics of individuals seem to determine behavioral patterns that are associated with better health throughout life and, consequently, prevent the progression of early cognitive changes to dementia.
Objective To identify which individuals have modified cognitive ratings after 24 months of follow-up and correlating with personality traits.
Methods One hundred and two volunteers were evaluated clinically and for personality characteristics and neuropsychological testing. Of these, 25 subjects were classified as cognitively normal (CN), 25 as subjective cognitive decline (SCD), 28 as nonamnestic mild cognitive impairment (naMCI), and 24 as amnestic mild cognitive impairment (amMCI) at baseline. Follow-up occurred over 2 years from the initial assessment, and the cognitive categories of the participants were re-analyzed every 6 months to observe differences in their classification.
Results Out of the 102 subjects, 65 remained at follow-up. The sample followed-up longitudinally was composed predominantly of women (65%), white (74%), with a mean age of 78 (±7.5) years old and 12 (±4.8) years of schooling. Throughout the process, 23% of CN, 15% of SDC, and 27% of naMCI individuals worsened cognitively. Amnestic with mild cognitive impairment volunteers remained stable or improved. Individuals with older age show more significant cognitive deterioration, and those with very low or high rates of the openness personality trait are associated with cognitive decline utilizing the Fisher exact test, probably because the open extremes influence choices, stress management, and behavioral maintenance.
Conclusion The factors most associated with cognitive change in this group of older adults were age and the intensity of the openness aspects of personality.