bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Machine Learning and Characterization in Battery Research: Toward Cognitive Digital Twins with Physics and Knowledge
Authors: Hu Erhai , Choo Hong Han , Zhang Wei , Sumboja Afriyanti , Anggraningrum Ivandini T. , Syahrial Anne Zulfia , Zhu Qiang , Xu Jianwei , Loh Xian Jun , Pan Hongge , Chen Jian , Yan Qingyu 
Published: January 2025

AbstractThe rapid advancement of battery technology has driven the need for innovative approaches to enhance battery management systems. In response, the concept of a cognitive digital twin has been developed to serve as a sophisticated virtual model that dynamically simulates, predicts, and optimizes battery behavior. These models integrate real‐time data with in‐depth physical insights, offering a comprehensive solution for battery management. Fundamental to this development are advanced characterization techniques such as microscopy, spectroscopy, tomography, and electrochemical methods—that provide critical insights into the underlying physics of batteries. Additionally, machine learning (ML) extends beyond predictive analytics to enhance the analytical capabilities. By uncovering deep physical insights, ML significantly improving the accuracy, reliability, and interpretability of these techniques. This review explores how integrating ML with traditional battery characterization techniques bridges the gap between deep physical insights and data‐driven analysis. The synergy not only enhances precision and computational efficiency but also minimizes human intervention, thereby paving the way for more robust and transparent digital twin technologies in battery research.
Advances and Challenges in SnTe‐Based Thermoelectrics
Authors: Wang Lijun , Moshwan Raza , Yuan Ningyi , Chen Zhi‐Gang , Shi Xiao‐Lei 
Published: January 2025

AbstractSnTe‐based thermoelectric materials have attracted significant attention for their exceptional performance in mid‐to‐high temperature ranges, positioning them as promising candidates for thermoelectric power generation. However, their efficiency is constrained by challenges related to electronic structure, defect chemistry, and phonon behavior. This review comprehensively summarizes advancements in SnTe thermoelectric materials and devices over the past five years, focusing on strategies to address these limitations. Key approaches include defect regulation, carrier transport optimization, and phonon engineering to enhance electrical conductivity, reduce thermal conductivity, and improve overall thermoelectric conversion efficiency. The review highlights breakthroughs in fabrication methods, doping and alloying, composite designs, and the development of novel nanostructures, with particular emphasis on 2D SnTe materials such as monolayers, bilayers, and thin films, which offer new opportunities for performance enhancement. Additionally, it provides an overview of SnTe‐based thermoelectric devices, covering fabrication techniques, performance optimization, stability, and flexible device development. Despite significant progress, challenges remain in developing n‐type SnTe materials, optimizing interfaces, ensuring long‐term stability, and maximizing conversion efficiency. This review fills gaps in the existing literature and offers valuable insights and guidance for future research aimed at improving thermoelectric properties, advancing device integration, and driving the commercial viability of SnTe‐based materials for practical applications.
Bioinspired Disordered Aerogel for Omnidirectional Terahertz Response
Authors: Wang Hui‐Ya , Hu Pengfei , Sun Xiao‐Bo , Hou Zhi‐Ling , Zhao Pei‐Yan , Zhou Lu , Yang Shu‐Hao , Geng Chunyan , Zhu Yaofeng , Wu Xiaojun , Wang Guang‐Sheng 
Published: January 2025

AbstractThe structural disorder of the black butterfly assists in capturing sunlight across a wider spectral and angular range, injecting infinite vitality for omnidirectional and stimuli‐responsive wave‐absorbing materials. Here, the disordered micro‐pores responding to terahertz (THz) waves through electromagnetic simulations, and then prepared via ice templating technology are analyzed and optimized. The customized disordered aerogel makes possible perfect terahertz response property with incidence‐angle‐insensitive and ultra‐broadband. Ti3C2Tx MXene/carboxymethyl cellulose aerogels realize excellent shielding effectiveness exceeding 70.32 dB and reflection loss of more than 43.02 dB over the frequency range of 0.3–1.5 THz. Tailoring the structural orientation of anisotropic aerogels functions as a versatile dynamic modulation approach along terahertz propagation direction. The porous structure with moderate conductivity gradually triggers the resonance effect of the cavity, approximating a resonance sphere (pore) and waveguide system (tube). Ultimately, gradient impedance aerogel is proposed integrating THz‐infrared stealth, hydrophobicity, and mechanical strength. This inspired biomimetic structural strategy will also enable various terahertz applications such as terahertz imaging, line‐of‐sight telecommunication, information encryption, and space exploration.
Polarization‐Dependent Color Modulation in Electrodeposited Cellulose Nanocrystals and Birefringent Multilayers
Authors: Fonseca Alexandre , Grey Paul , Mendes Bruno , Hamad Wadood Y. , Fortunato Elvira , Martins Rodrigo , Pereira Luís , Gaspar Diana 
Published: January 2025

AbstractCellulose nanocrystals (CNCs) can self‐organize into a chiral nematic liquid crystal phase with a left‐handed helical arrangement, resulting in structurally intrinsic photonic properties in the dry state. These include iridescence and the selective reflection of left circular polarized light, where the wavelength is typically defined by the surface chemistry and charge of the CNCs before self‐assembly. This work demonstrates how passive and dynamic stimulation can modulate the reflected wavelength across the entire visible light range. While the former is achieved through ion exchange at the CNC surface and electrophoretic deposition, the latter can be achieved by combining CNC layers with a thin‐film heater. Further, the multilayer electrodeposited CNC films are combined with a birefringent polypropylene tape as a retardation plate to enable reflection of both left‐handed and right‐handed circularly polarized light (LCPL and RCPL, respectively). This architecture allows various colors in LCPL and RCPL channels to be obtained, depending on the number of layers and the initial photonic bandgap conditions of the CNC films, which will not be possible with regular self‐assembled CNC films. The results obtained demonstrate the potential of CNC multilayer birefringent structures to be applied in photonics, imaging, sensing, and information processing.
Redox‐Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3‐Mediated NRF2 Deubiquitination
Authors: Xu Weimin , Hua Zhebin , Wang Yaosheng , Tang Wenbo , Ge Wensong , Chen YingWei , Wang Zhongchuan , Gu Yubei , Liu Chen‐Ying , Du Peng 
Published: January 2025

AbstractInflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin‐1 regulator 1 (AMBRA1) is a positive modulator of the NF‐κB pathway that promotes intestinal inflammation. However, its effect on intestinal redox state and whether AMBRA1 is regulated by oxidative stress remain unknown. In this study, it is found that AMBRA1 functions as a pro‐oxidative factor that increases oxidative stress in intestinal epithelial cells (IECs) in vitro and in vivo. Mechanistically, the N‐terminal F1 domain is required for AMBRA1 to competitively interact with the N‐terminal domain of NRF2, thereby antagonizing the interaction between deubiquitinating protein 3 (DUB3) and NRF2, suppressing DUB3‐mediated NRF2 deubiquitination, and leading to NRF2 degradation. In response to H2O2 stimulation, the interaction between AMBRA1 and ubiquitin‐specific protease 7 (USP7) is enhanced, facilitating USP7 to deubiquitinate AMBRA1 at K83 and K86 and stabilize AMBRA1. Notably, the USP7 inhibitor, P5091, inhibits oxidative stress and colitis in vivo. Elevated AMBRA1 expression in inflamed colon tissues from ulcerative colitis patients is negatively correlated with decreased NRF2 protein levels. Overall, this study identifies AMBRA1 as a pro‐oxidative factor in IECs and provides a redox‐modulating therapeutic strategy for targeting USP7/AMBRA1 in IBD.
Unraveling the Microenvironment and the Pathogenic Axis of HIF‐1α–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single‐Cell Atlas
Authors: Zhang Deyu , Ma Congjia , Wang Zhen , Liu Yanfang , Liu Zaoqu , Li Wanshun , Liu Yue , Wu Chang , Sun Liqi , Jiang Fei , Jiang Hui , Su Xiaoju , Peng Lisi , Li Jiayu , Wang Xinyue , Yin Hua , Wan Dongling , Zhou Yuyan , Tian Xiaorong , Li Shiyu , Jin Zhendong , Ji Baoan , Li Zhaoshen , Huang Haojie 
Published: January 2025

AbstractAutoimmune pancreatitis (AIP) is identified as a severe chronic immune‐related disorder in pancreas, including two subtypes. In this study, pancreatic lesions in patients diagnosed as either type 1 AIP or type 2 AIP are examined, and these patients’ peripheral blood at single‐cell level. Furthermore, flow cytometry, immunofluorescence, and functional assays are performed to verify the identified cell subtypes. In type 1 AIP, there is a notable increase in the amount of B cells and plasma cells, and IgG4+ plasma cells are key pathogenic cells of AIP. The differentiation path of naïve‐stage B cells into IgG4+ produced plasma cells is observed, and an increased amount of T helper cells and T follicular helper (Tfh) cells. This study also reveals that HIF‐1α, an activated transcriptional factor, can directly bind to promoter site of NAMPT, promoting higher levels of visfatin production in HIF1A+ classical monocytes. Pancreatic stellate cells can be activated by extracellular visfatin and promote the development of fibrotic response in pancreatic lesions across both AIP subtypes. The current findings shed light on the exploration of dynamic alterations in peripheral blood cells and cell subgroups in pancreatic lesions of AIP, while elucidating a pathogenic cell subset and potential fibrosis mechanism of AIP.
Osteoblast‐Derived Mitochondria Formulated with Cationic Liposome Guide Mesenchymal Stem Cells into Osteogenic Differentiation
Authors: Kim Hye‐Ryoung , Woo Seonjeong , Cho Hui Bang , Lee Sujeong , Cho Chae Won , Park Ji‐In , Youn Seulki , So Gyuwon , Kang Sumin , Hwang Sohyun , Kim Hye Jin , Park Keun‐Hong 
Published: January 2025

AbstractWhile mitochondria are known to be essential for intracellular energy production and overall function, emerging evidence highlights their role in influencing cell behavior through mitochondrial transfer. This phenomenon provides a potential basis for the development of treatment strategies for tissue damage and degeneration. This study aims to evaluate whether mitochondria isolated from osteoblasts can promote osteogenic differentiation in mesenchymal stem cells (MSCs). Mitochondria from MSCs, which primarily utilize glycolysis, are compared with those from MG63 cells, which depend on oxidative phosphorylation. Mitochondria from both cell types are then encapsulated in cationic liposomes and transferred to MSCs, and their impact on differentiation is assessed. Mitochondria delivery from MG63 cells to MSCs grown in both two‐ and three‐dimensional cultures results in increased expression of osteogenic markers, including Runt‐related transcription factor 2, Osterix, and Osteopontin, and upregulation of genes involved in Bone morphogenetic protein 2 signaling and calcium import. This is accompanied by increased calcium influx and regulated by the Wnt/β‐catenin signaling pathway. Transplantation of spheroids containing MSCs with MG63‐derived mitochondria in bone defect animal models improves bone regeneration. The results suggest that delivery of MG63‐derived mitochondria effectively guides MSCs toward osteogenesis, paving the way for the development of mitochondria‐transplantation therapies.
Temporal Association Cortex Gates Sound‐Evoked Arousal from NREM Sleep
Authors: Yu Haipeng , Wang Jincheng , Pang Ruiqi , Chen Penghui , Luo Tiantian , Zhang Xuan , Liao Yatao , Hu Chao , Gu Miaoqing , Luo Bingmin , Shi Zhiyue , Li Mengyao , Zhang Yueting , Wei Qiaoqian , Yuan Wei , Xie Hui , Chen Zhiyi , Liu Hongbang , Ren Shuancheng , Chen Xiaowei , Zhou Yi 
Published: January 2025

AbstractSound‐evoked wakefulness from sleep is crucial in daily life, yet its neural mechanisms remain poorly understood. It is found that CaMKIIα+ neurons in the temporal association cortex (TeA) of mice are not essential for natural awakening from sleep. However, optogenetic activation of these neurons reliably induces wakefulness from non‐rapid eye movement (NREM) sleep but not from rapid eye movement (REM) sleep. In vivo electrophysiological and calcium recordings further demonstrated that TeA neurons are monotonically tuned to sound intensity but not frequency. More importantly, it is found that the activity of CaMKIIα+ neurons in TeA can gate sound‐evoked arousal from NREM sleep, which is further confirmed by optogenetic manipulations. Further investigation reveals that the baseline excitability of TeA CaMKIIα+ neurons and the delta oscillations in the electroencephalogram are particularly important in regulating the evoked activity of TeA neurons. Anatomical and functional screening of downstream targets of TeA reveals that excitatory projections from TeA glutamatergic neurons to glutamatergic neurons in the basolateral/lateral amygdala are critical for modulating sound‐evoked arousal from NREM sleep. These findings uncover a top‐down regulatory circuit that selectively governs sound‐evoked arousal from NREM sleep, with the TeA functioning as a key connecting cortex to subcortical regions.
Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Authors: Cho Hui Bang , Kim Hye‐Ryoung , Lee Sujeong , Cho Chae Won , Park Ji‐In , Youn Seulki , So Gyuwon , Kang Sumin , Kim Hye Jin , Park Keun‐Hong 
Published: January 2025

AbstractMitochondrial transfer emerges as a promising therapy for the restoration of mitochondrial function in damaged cells, mainly due to its limited immunogenicity. However, isolated mitochondria rapidly lose function because they produce little energy outside cells. Therefore, this study investigates whether near infrared (NIR)‐mediated nicotinamide adenine dinucleotide (NADH) pre‐treatment enhances mitochondrial function and stability in mitochondria‐donor cells prior to transplantation. Clinical applications of NADH, an essential electron donor in the oxidative phosphorylation process, are restricted due to the limited cellular uptake of NADH. To address this, a photo‐mediated method optimizes direct NADH delivery into cells and increases NADH absorption. L6 cells treated with NADH and irradiated with NIR enhanced NADH uptake, significantly improving mitochondrial energy production and function. Importantly, the improved functional characteristics of the mitochondria are maintained even after isolation from cells. Primed mitochondria, i.e., those enhanced by NIR‐mediated NADH uptake (P‐MT), are encapsulated in fusogenic liposomes and delivered into muscle cells with mitochondrial dysfunction. Compared to conventional mitochondria, P‐MT mitochondria promote greater mitochondrial recovery and muscle regeneration. These findings suggest that NIR‐mediated NADH delivery is an effective strategy for improving mitochondrial function, and has the potential to lead to novel treatments for mitochondrial disorders and muscle degeneration.
Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance
Authors: Yu Jing , Gao Xiaoyan , Shi Hang , Zhang Lijun , Nie Wenlong , Zhang Ruochen , Fang Minglv , Liu Ying , Yan Yingxuan , Fan Bingbing , Wu Chengyuan , Huang Cheng , Fan Shengjie 
Published: January 2025

AbstractEnvironmental factors are linked to aging and age‐related diseases. Emerging evidence suggests that enhancing body's resistance to xenobiotics might be an anti‐aging strategy. The constitutive androstane receptor (CAR) regulates drug‐metabolizing enzymes and transporters, coordinating metabolism and immune responses to adapt to stress triggered by exogenous exposure. However, the impact of activating CAR on aging remains unknown. In this study, Caenorhabditis elegans (C. elegans), drug‐induced premature aging mice, and senescence accelerated P8 (SAMP8) mice are used as models to explore the effects of CAR activation on lifespan and healthspan, along with the underlying mechanisms. The results showed that hCAR agonist CITCO and mCAR agonist TCPOBOP prolonged the lifespan and healthspan in model organism. The longevity effects of CITCO and TCPOBOP were attenuated in CAR homozygous nhr‐8/daf‐12 mutant C. elegans as well as CAR−/− mice. In C. elegans, CITCO activated both anti‐stress and detoxification genes, and increased the resistance to environmental adversities. Additionally, the lifespan‐extending and xenobiotic resistant effects of CITCO might be related to the regulation of age‐related pathways. Furthermore, CITCO improved age‐related neurodegeneration in C. elegans models. Taken together, the results suggest that the longevity effects of CAR agonists may be related to the enhancement of xenobiotic resistance of animals.
Covalent Organic Framework Membranes with Spatially Aligned Ionic Sites Achieve Record Thermo‐Osmotic Output Power Density
Authors: Lai Zhuozhi , Su Haitao , Xian Weipeng , Guo Qing , Meng Qing‐Wei , Wu Di , Wang Sai , Sun Qi 
Published: January 2025

AbstractThe advancement of nanofluidic membranes is critical for mimicking bioelectrogenic ion‐channel mechanisms and boosting output power density, essential for sustainable energy applications. The energy conversion efficiency of these devices significantly relies on the ion conductivity and permselectivity of the membranes. Membranes with aligned one‐dimentional (1D) pores, high pore density, and organized dangling ionic groups are theorized to offer superior ion permeability and selectivity, yet these configurations remain significantly underexplored. Herein, the successful fabrication of oriented ionic covalent organic framework (COF) membranes is presented. These membranes exhibit precisely aligned cationic and anionic sites within their pore channels, achieved through post‐synthetic modification using click chemistry, which shows high ion permselectivity and conductivity. When incorporated into full‐cell thermo‐osmotic generators, these membranes deliver an impressive output power density of 195 W m−‍2 under a 50‐fold salinity gradient (NaCl: 0.01 m ‖ 0.5 m ‖ 0.01 m) along with a 35 K temperature differential. This power output substantially increases 2.41 times to 471 W m−2 when the salinity gradient is enhanced tenfold, surpassing the performance of existing nanofluidic membranes under similar conditions and thus offering a promising avenue for enhancing efficiency in energy and resource utilization.
Impact of prostate cancer screening in European ancestry un‐affected men with germline DNA repair pathogenic variants
Authors: Fasulo Vittorio , Chiarelli Giuseppe , Garofano Giuseppe , Ripamonti Carla Barbara , Barile Monica , Bianchi Paolo , Morenghi Emanuela , Benetti Alessio , Aljoulani Muhannad , Finocchiaro Alessio , Paciotti Marco , Avolio Pier Paolo , Beatrici Edoardo , Arena Paola , Saita Alberto , Hurle Rodolfo , Maura Federica , Da Rin Giorgio , Asselta Rosanna , Capalbo Anita , Soldà Giulia , Casale Paolo , Buffi Nicolò Maria , Lughezzani Giovanni , Lazzeri Massimo 
Published: January 2025

AbstractBackground and ObjectiveProstate cancer (PCa) is a significant global health concern, ranking as the second most prevalent cancer among men worldwide. Genetic factors, particularly germline pathogenic variants (PVs) in DNA repair genes (DRGs), play a crucial role in PCa predisposition. Our study aimed to assess patients' adherence to a targeted PCa screening program targeting high‐risk individuals with DRG PVs and evaluate the potential reduction in biopsy and MRI rates by employing our screening protocol.MethodsWe conducted a prospective ongoing trial evaluating targeted PCa screening in men with documented PVs in DRGs. Screening involved annual assessment of medical history, physical examination, prostate‐specific antigen (PSA) testing, Prostate Health Index (PHI), and multiparametric magnetic resonance imaging (mpMRI) when indicated. Descriptive statistics were used to analyse patient characteristics, and adherence to screening was evaluated at three time points: baseline (T0), one year (T1), and two years (T2) from enrolment.Key Findings and LimitationsA total of 101 high‐risk individuals were enrolled, with a median age of 52 years. Adherence to screening was high, with 72.3% of patients attending the first annual follow‐up (T1) and 100% attending the second follow‐up (T2). Despite elevated PSA levels in some patients, no PCa was detected during the study period. However, our screening protocol demonstrated the potential in reducing unnecessary biopsies and MRIs, particularly in patients with elevated PSA but low PHI values. Limitations include the ongoing nature of the study, small sample size, and lack of non‐carrier controls.Conclusions and Clinical ImplicationsOur findings described a new PCa screening strategy integrated with genetic risk factors. The incorporation of PHI shows promise in improving the efficiency of diagnostic procedures while minimizing unnecessary interventions. High adherence among high‐risk individuals underscores the potential effectiveness of targeted screening programs.
Modeling the Performance of an Anaerobic Moving Bed Biofilm Reactor
Authors: Cai Yuhang , Boltz Joshua P. , Rittmann Bruce E. 
Published: January 2025

ABSTRACTSub‐models representing transformation processes by microorganisms and hydrolases, a one‐dimensional (1‐D) biofilm, and a bioreactor were integrated to simulate organic‐matter fermentation and methane (CH4) production in an anaerobic moving bed biofilm reactor (AnMBBR). The integrated models correctly represented all experimental observations and identified mechanisms underlying how and why AnMBBR performance changed when the volumetric loading rate (VLR) of total chemical oxygen demand (TCOD) increased from 3.9 to 19.5 kg CODT/m3‐d. The fractional removal of TCOD and CH4 production decreased as the VLR of TCOD increased, in part, due to an increasing biofilm thickness that filled the protected channels in the interior of the plastic carriers and led to a decrease in biofilm surface area and an increase in the mass‐transfer boundary layer. Also, the ~25‐day duration for each VLR of TCOD was too brief to allow the biofilm to establish a new quasi‐steady state with respect to biofilm thickness. The mechanistic understanding of how biofilm characteristics and process performance respond to increased VLR of TCOD can be applied in engineering practice to improve AnMBBR process design and operation.