bluuebunny/crossref_metadata_2025_split huggingface dataset:
The problem of antibiotic resistance in the treatment of small domestic animals according to laboratory research data in the Moscow metropolis for the first half of 2023
Authors: Filimonova A. D. , Shabeykin A. A. , Laishevtsev A. I. 
Published: December 2023

Relevance. Widespread irrational use of antibiotics has turned antimicrobial resistance into a global problem not only in veterinary medicine, but also in healthcare, which is exacerbated by the cessation of antibiotic development. This study will help practitioners to promptly make decisions on the choice of tactics of antibacterial treatment even before the results of laboratory diagnostics.The aim of the study is to conduct a cross–sectional study for 2023 on the territory of the Moscow metropolis, aimed at determining the most common opportunistic pathogens in companion animal populations detected in diseases of various organ groups, while simultaneously investigating the phenomenon of antibiotic resistance and compiling a list of antibacterial agents with ranking by their effectiveness.Methods. The determination of antibiotic sensitivity was carried out by the discodiffuse method (DDM) in accordance with MUC 4.2.1890-04 “Determination of the sensitivity of microorganisms to antibacterial drugs”.Results. As a result of the research work, a study of samples of microbiological crops taken from companion animals (parrots, cats and domestic dogs) on the territory of the Moscow metropolis was carried out and 258 pathogens were identified.The most common bacteria were identified: epidermidis and Escherichia. coli are most often isolated from the urinary system of animals;gram-negative pathogens with a predominance of coli strains are most often isolated from the gastrointestinal tract;in dermatological diseases of animals, gram-positive bacteria with the dominance of spp. are most often isolated.The antibiotic resistance of pathogens was investigated, as well as the ranking of antibacterial drugs by effectiveness to certain types of microorganisms was carried out.
Inovasi Pelayanan Publik Di Kantor Imigrasi Kelas II TPI Batulicin
Authors: Riduan Muhammad , Rahmadanita Annisa , Nurrahman Agung 
Published: December 2023

Penelitian ini dilatarbelakangi oleh kesulitan yang dihadapi oleh kelompok rentan, seperti individu yang sakit, disabilitas, dan Lansia di atas 65 tahun, yang ingin membuat paspor di Kantor Imigrasi Kelas II TPI Batulicin. Oleh sebab itu, Kantor Imigrasi perlu mengembangkan inovasi untuk mempermudah proses bagi kelompok tersebut yang tidak dapat mengunjungi kantor secara langsung. Tujuan penelitian ini adalah untuk memperoleh gambaran tentang inovasi layanan publik yang dikhususkan pada beberapa aplikasi sebagai contoh. Dengan menggunakan data dan deskripsi rinci, pendekatan kualitatif digunakan untuk mencapai tujuan ini. Wawancara, observasi, dan pendokumentasian dengan menggunakan analisis reduksi, penyajian data, dan penarikan kesimpulan digunakan sebagai pendekatan pengumpulan dan analisis data. Hasil penelitian menunjukkan bahwa inovasi layanan publik di Kantor Imigrasi Batulicin dilakukan dengan menyediakan inovasi M-Paspor dan Layanan Micin Darurat. Dari keenam dimensi yang digunakan dalam penelitian, terdapat 2 (dua) dimensi yang masih kurang baik yaitu aspek kesesuaian dan aspek kerumitan. Sementara itu 4 (empat) aspek lainnya sudah terselenggara dengan baik. Kesimpulannya, penyelenggaraan inovasi pelayanan publik yang di Kantor Imigrasi Batulicin, terselenggara dengan baik.
Kata Kunci: Aplikasi M-Paspor, Inovasi Pelayanan Publik, Layanan Micin Darurat.
OPTIMALISASI KAMPUNG SIAGA BENCANA DALAM MITIGASI BENCANA DI KOTA BALIKPAPAN PROVINSI KALIMANTAN TIMUR
Authors: Dimaputri Asha Mutiara , Mujahidin Mujahidin 
Published: December 2023

Kota Balikpapan merupakan salah satu kota yang dianggap sebagai penyangga Ibu Kota Nusantara, namun masih memiliki resiko becana. Lebih jauh lagi hingga kini, belum ada penelitian yang membahas tentang optimalisasi dari adanya Kampung Siaga Bencana sebagai bagian dari solusi menghadapi bencana. Terkait hal tersebut, penelitian ini bertujuan untuk memperoleh gambaran umum mengenai optimalisasi Kampung Siaga Bencana dalam mitigasi bencana di Kota Balikpapan Provinsi Kalimantan Timur. Metode penelitian adalah kualitatif. Penulis melakukan wawancara semi-terstruktur, observasi dan dokumentasi pada pengumpulan data penelitian. Hasil dari penelitian menunjukkan bahwa Dimensi tujuan menunjukkan bahwa masyarakat telah memahami tujuan dari terbentuknya KSB namun masyarakat belum memahami berbagai bentuk mitigasi bencana yang ada. Dimensi alternatif keputusan menunjukkan bahwa alternatif keputusan yang diambil oleh Dinas Sosial Kota Balikpapan yaitu melalui partisipasi masyarakat dalam pelaksanaan program KSB dengan jumlah KSB yang dibentuk. Dimensi sumber daya menunjukkan adanya keterbatasan anggaran dalam optimalisasi program KSB, belum memiliki sarana dan prasarana yang memadai, dan dari segi sumber daya manusia menunjukkan adanya keterbatasan jumlah sumber daya manusia terutama tenaga ahli dibidang kebencanaan. Kesimpulannya, optimalisasi kampung siaga bencana dalam mitigasi bencana di Kota Balikpapan Provinsi Kalimantan Timur telah dilaksanakan dengan cukup baik.

Kata Kunci: Kampung Siaga Bencana; Kelurahan Tangguh Bencana; Mitigasi Bencana
El paradigma de H. Fayol y la praxis docente en tres niveles educativos de Caldas, Colombia
Authors: García Ocampo Ximena 
Published: December 2023

Reconocer la institución educativa como espacio de transformación social ha sido un interés permanente de los diferentes actores que conforman la sociedad, siendo el acceso a la educación uno de los medios para disminuir la pobreza. En esta investigación se busca describir la relación entre el paradigma de Henry Fayol y la praxis docente en tres niveles educativos del sector estatal del Departamento de Caldas Colombia, el método empleado a través de la aplicación de dos instrumentos corresponde al enfoque es mixto: Cualitativo – Cuantitativo. Se evidencio la correspondencia de los principios administrativos propuestos por Henry Fayol con la acción del docente en el aula de clase. En el principio administrativo de disciplina de la teoría clásica de Henry Fayol aplicados por el docente estatal de básica primaria, secundaria y media del departamento de Caldas, se reconocieron los aspectos tales como aplicación de normas, realizar control y seguimiento a las actividades, aplicar estímulos entre otros que se entrelazan con los descritos por Fayol (1961), Gaudemar (1991), Castillo (1991), Foucault (2002), Wittke (2005) y Montes (2007) frente al tema de la conducta, de las convenciones establecidas por la empresa, de la obediencia y la forma de establecer y fomentar la disciplina.
Preparation of an N–S dual-doped black fungus porous carbon matrix and its application in high-performance Li–S batteries
Authors: Zhao Liping , Zhao Ye , Zhao Lihe , Liu Gang 
Published: December 2023

A nitrogen–sulfur dual-doped black fungus porous carbon (NS-FPC) matrix was prepared with natural black fungus as the carbon source and cysteine as the nitrogen–sulfur source. A black fungus-based solution was obtained by hydrothermal treatment. After further carbonization activation and combination with sulfur processing, the NS-FPC/S positive electrode materials were prepared. The uniform recombination of biomass carbon provides an efficient conductive framework for sulfur. The porous structure is conducive to the transport of electrolytes. Heteroatom doping can provide a more active site. The structure and composition analyses of the materials were carried out using X-ray diffraction (XRD). The electronic binding energy and bonding state were analyzed by X-ray photoelectron spectroscopy (XPS). The morphology was observed by scanning electron microscopy and transmission electron microscopy. The specific surface area and pore size distribution were analyzed using an N2 adsorption–desorption experiment. Sulfur loading was determined through thermogravimetric analysis. The electrochemical performance of NS-FPC/S in Li–S batteries was systematically investigated. The result shows that the NS-FPC/S electrode maintains more than 1,000 mAh g-1 reversible capacity after 100 cycles at 0.2 C current density, with a capacity retention of 85%. The cycle and rate performance are both considerably superior to those of traditional activated carbon materials.
Autoantibodies predict type 1 diabetes after gestational diabetes – a 23-year cohort study
Authors: Luiro Kaisu , Auvinen Anna-Maaria , Auvinen Juha , Jokelainen Jari , Järvelä Ilkka , Knip Mikael , Tapanainen Juha S. 
Published: December 2023

ObjectiveTo study the predictive value of autoantibodies for type 1 (T1DM) and type 2 (T2DM) diabetes morbidity after gestational diabetes (GDM) in a 23-year follow-up study.DesignProspective population-based cohort study.MethodsWe studied 391 women with GDM, and 391 age- and parity-matched controls, who delivered in 1984–1994. Four autoantibodies were analysed in first-trimester blood samples: islet cell autoantibodies (ICAs), glutamic acid decarboxylase autoantibodies (GADAs), insulin autoantibodies (IAAs) and insulinoma-associated antigen-2 autoantibodies (IA-2As). Two follow-up questionnaires (1995–1996, 2012–2013) were sent to assess development of T1DM and T2DM. Predictive value of autoantibodies and clinical factors were analysed by conditional linear regression and ROC analyses.ResultsSingle autoantibody positivity was detected in 12% (41/342) of the GDM cohort and in 2.3% (8/353) of the control cohort. In the GDM cohort, 2.6% (9/342) tested positive for two autoantibodies and 2.3% (8/342) for three autoantibodies, whereas only one subject in the control cohort had two autoantibodies. ICA positivity was found in 12.5% of the cases, followed by GADA (6.0%), IA-2A (4.9%) and IAA (1.2%). In the control cohort, GADA positivity was found in 1.4%, IA-2A in 0.8%, IAA in 0.6%, and ICA in 0.3% of the subjects. Detection of ICA, GADA and/or IA-2A autoantibodies decreased T1DM-free survival time and time to diagnosis. All subjects with three positive autoantibodies developed T1DM within seven years from the GDM pregnancy. Development of T2DM after GDM occurred independent of autoantibody positivity.ConclusionDevelopment of T1DM can be reliably predicted with GADA and ICA autoantibodies during early pregnancy.
Prevalence and predictors of developing vision-threatening diabetic retinopathy within the first three years of type 2 diabetes
Authors: Yan Jia , Li Bo , Chen Ye , Gu Chufeng , Dai Guosheng , Zhang Qin , Zheng Zhi , Luo Dawei , Zhao Shuzhi , Zhou Chuandi 
Published: December 2023

PurposeTo investigate the prevalence of diabetic retinopathy (DR) and vision-threatening DR (VTDR) in patients with type 2 diabetes mellitus (T2DM) stratified by the duration of diabetes and to identify the clinical variations and risk factors for VTDR occurring at different stages of T2DM.MethodsThis was a retrospective comparative study. Patients were divided into short- (≤3 years), intermediate- (3–7 years), and long-duration (&gt;7 years) groups. All patients were followed-up for DR and VTDR development. Risk factors were explored using logistic regression analysis.ResultsA total of,2961 patients were included; among them, 1,036 (35.0%) patients developed DR, and 293 (9.9%) had VTDR. The frequency of VTDR in patients who developed DR in the short-duration group was significantly higher than that in the intermediate-duration group (25.7% vs. 15.0%; p = 0.019), but comparable with that of the long-duration group (25.7% vs. 31.8%; p = 0.138). Patients who developed VTDR within the first 3 years of T2DM were more likely to have a family history of diabetes (p = 0.024), had higher glycated hemoglobin (p = 0.025), were males (p = 0.042), and were notably older at the onset of diabetes (p &lt;0.001) but younger when diagnosed with DR (p &lt;0.001). Moreover, higher glycated hemoglobin (OR = 1.14; 95% CI: 1.00–1.29; p = 0.043) and diabetic nephropathy (DN) (OR = 2.31; 95% CI: 1.08–4.91; p = 0.030) were independent risk factors for developing VTDR during the first 3 years of T2DM.ConclusionThe risk of DR is not high in persons with ≤3 years’ duration of T2DM, however, if afflicted, the risk of VTDR should never be neglected. More frequent retinal screening is warranted in patients with newly diagnosed T2DM.
Association between type 1 diabetes mellitus and ankylosing spondylitis: a two-sample Mendelian randomization study
Authors: Zhang Ju , Qi Jiaping , Li Yixuan , Wang Jing , Jiang Huan , Sun Qiong , Gu Qinchen , Ying Zhenhua 
Published: December 2023

ObjectiveThe development of ankylosing spondylitis (AS) is closely related to autoimmune system dysfunction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease that is a risk factor for many diseases. This study aimed to investigate the causal relationship between T1DM mellitus and AS genetically.MethodsA genome-wide association study (GWAS) of causal relationships between exposure (T1DM) and outcome (AS) was performed using summary data from the GWAS database. We conducted a two-sample Mendelian randomization (MR) study of these two diseases. Inverse variance weighting (IVW) was used as the primary analysis method, with MR Egger, weighted median, and weighted mode used as supplementary methods. Sensitivity analyses were performed using Cochran’s Q test, MR-Egger intercept, MR-Pleiotropy RESidual Sum and outlier methods, leave-one-out analysis, and funnel plots.ResultsA total of 11 single nucleotide polymorphisms (SNPs)were identified for instrumental variables(IVs) for MR analysis.IVW found that T1DM was causally associated with AS ((IVW: OR = 1.0006 (95% CI 1.0001, 1.0011), p = 0.0057; MR-Egger: OR = 1.0003 (95% CI 0.9995, 1.0012), p = 0.4147; weighted median: OR = 1.0006 (95% CI 1.0003, 1.0008), p = 0.0001; weighted mode: OR = 1.0007 (95% CI 1.0005, 1.0009), p = 0.0001). No horizontal pleiotropy was found for the MR-Egger intercept, and leave -one-out analysis found that the results remained stable after the removal of individual SNPs.ConclusionThe results of the two-sample MR analysis supported a causal relationship between T1DM and AS risk.
Associations of the circulating levels of cytokines with risk of ankylosing spondylitis: a Mendelian randomization study
Authors: Ye Yang , Wang Chuan-en , Zhong Rui , Xiong Xiao-ming 
Published: December 2023

BackgroundObservational studies have shown that changes in circulating cytokine/growth factor levels occur throughout the initiation and progression of ankylosing spondylitis (AS), yet whether they are etiologic or downstream effects remains unclear. In this study, we performed a summarized-level bidirectional Mendelian randomization (MR) analysis to shed light on the causal relationship between the two.MethodsGenetic instrumental-variables (IVs) associated with circulating cytokine/growth factor levels were derived from a genome-wide association study (GWAS) of 8,293 European individuals, whereas summary data for the AS were obtained from a FinnGen GWAS of 166,144 participants. We used the inverse-variance-weighted (IVW) method as the main analysis for causal inference. Furthermore, several sensitivity analyses (MR-Egger, weighted median, MR-PRESSO and Cochran’s Q test) were utilized to examine the robustness of the results. Finally, reverse MR analysis was performed to assess reverse causality between AS and circulating cytokine/growth factor levels.ResultsAfter Bonferroni correction, circulating levels of Cutaneous T-cell attracting (CTACK) and Monocyte specific chemokine 3 (MCP-3) were positively associated with a higher risk of AS (odds ratio [OR]: 1.224, 95% confidence interval [95% Cl]: 1.022 ~ 1.468, P = 0.028; OR: 1.250, 95% Cl: 1.016 ~ 1.539, P = 0.035). In addition, elevated circulating levels of Basic fibroblast growth factor (FGF-basic), Granulocyte colony-stimulating factor (G-CSF) and MCP-3 was considered a consequence of AS disease (β = 0.023, P = 0.017; β = 0.017, P = 0.025; β = 0.053, P = 0.025). The results of the sensitivity analysis were generally consistent.ConclusionThe present study supplies genetic evidence for the relationship between circulating cytokine levels and AS. Targeted interventions of specific cytokines may help to reduce the risk of AS initiation and progression.
Role of gut microbiota and inflammatory factors in acute respiratory distress syndrome: a Mendelian randomization analysis
Authors: Ma Jiawei , Zhu Zigang , Yishajiang Yisikandeer , Alarjani Khaloud Mohammed , Hong Lei , Luo Liang 
Published: December 2023

BackgroundAcute respiratory distress syndrome (ARDS) is a serious lung ailment marked by significant inflammation and damage in the alveoli and capillaries of the lungs. Recent research suggests a strong correlation between the onset and advancement of ARDS and an imbalance in the gut microbiota (GM).MethodsIn this investigation, Mendelian randomization (MR) analysis was utilized, drawing on data from publicly accessible genome-wide association studies. The primary focus was on examining the interplay between GM, inflammatory factors (IFs) and ARDS. Instrumental variables were established through genetic modifications of GM and IFs. Various statistical analysis methods including the inverse-variance weighted model, MR-Egger method and Wald ratio test were applied for comprehensive data analysis.ResultsEight bacterial taxa within the GM demonstrated a potential causal link with development of ARDS. Notably, the phylum Actinobacteria and the genus Intestinibacter exhibited a negative association with the risk of ARDS. However, Erysipelotrichales (id. 2,148), Victivallis (id. 2,256), Ruminococcaceae UCG014 (id. 11,371), Eubacterium ruminantium group (id. 11,340), Erysipelotrichaceae (id. 2,149) and Erysipelotrichia (id. 2,147) demonstrated a positive association with ARDS risk. Additionally, the study identified a potential causal relationship between the inflammatory factors interleukin-16 and C-C motif chemokine 3 with the occurrence of ARDS.ConclusionThis study strongly suggests that the interaction between gut microbiota (GM) and inflammatory factors (IFs) significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS). This underscores their crucial involvement in both the initiation and advancement of this severe lung disorder.
Effect of decreased platelets on postoperative recurrence of chronic subdural hematoma
Authors: Yagi Kenji , Matsubara Maoki , Kanda Eiichiro , Minami Yukari , Hishikawa Tomohito 
Published: December 2023

IntroductionChronic subdural hematoma (CSDH) is commonly treated using simple burr hole surgery. However, postoperative recurrence occurs at a relatively high rate of 10–20%. A decrease in platelet count (PC) may be associated with recurrence via a hemostasis disorder; however, this association has not been well-studied. Therefore, this study aimed to investigate the association between PC and postoperative CSDH recurrence.MethodsWe retrospectively reviewed the data for CSDHs in 488 cerebral hemispheres of 431 patients who underwent burr hole surgery at our institution between January 2013 and December 2022. The association between preoperative PC and postoperative CSDH recurrence was investigated. We used the first quartile of PC, PC &lt; 170 × 103/μL to define a threshold for decreased PC.ResultsIn total, 459 cerebral hemispheres with CSDHs in 405 patients were followed up postoperatively for at least 3 months or until CSDH disappeared. CSDH recurred in 39 (8.5%) cerebral hemispheres. The recurrence rate was gradually increased in parallel with a decreasing PC. Among 109 CSDHs with a decreased PC (&lt;170 × 103/μL), 15 (13.8%) recurred, whereas only 24 (6.9%) of 350 CSDHs without a decreased PC recurred (p = 0.03). In univariable logistic analysis, eosinophil-rich blood (≥100/μL eosinophils in peripheral blood) and a decreased PC were significant risk factors. Multivariable analysis showed that eosinophil-rich blood (adjusted odds ratio, 2.51; 95% confidence interval, 1.26–4.99; p = 0.009) and a decreased PC (adjusted odds ratio, 2.15; 95% confidence interval, 1.07–4.35; p = 0.03) were independent risk factors for recurrence.ConclusionOur study showed that a decrease in PC was associated with postoperative CSDH recurrence. Patients with CSDH and a decreased PC require careful postoperative follow-up.
The profiles and clinical significance of extraocular muscle-expressed lncRNAs and mRNAs in oculomotor nerve palsy
Authors: Wu Lianqun , Shi Mingsu , Liang Yu , Huang Jiaqiu , Xia Weiyi , Bian Hewei , Zhuo Qiao , Zhao Chen 
Published: December 2023

IntroductionOculomotor nerve palsy (ONP) arises from primary abnormalities in the central neural pathways that control the extraocular muscles (EOMs). Long non-coding RNAs (lncRNAs) have been found to be involved in the pathogenesis of various neuroparalytic diseases. However, little is known about the role of lncRNAs in ONP.MethodsWe collected medial rectus muscle tissue from ONP and constant exotropia (CXT) patients during strabismus surgeries for RNA sequencing analysis. Differentially expressed mRNAs and lncRNAs were revealed and included in the functional enrichment analysis. Co-expression analysis was conducted between these differentially expressed mRNAs and lncRNAs, followed by target gene prediction of differentially expressed lncRNAs. In addition, lncRNA-microRNA and lncRNA-transcription factor-mRNA interaction networks were constructed to further elaborate the pathological changes in medial rectus muscle of ONP. Furthermore, RT-qPCR was applied to further validate the expression levels of important lncRNAs and mRNAs, whose clinical significance was examined by receiver operating characteristic (ROC) curve analysis.ResultsA total of 618 differentially expressed lncRNAs and 322 differentially expressed mRNAs were identified. The up-regulated mRNAs were significantly related to cholinergic synaptic transmission (such as CHRM3 and CHRND) and the components and metabolism of extracellular matrix (such as CHI3L1 and COL19A1), while the down-regulated mRNAs were significantly correlated with the composition (such as MYH7 and MYL3) and contraction force (such as MYH7 and TNNT1) of muscle fibers. Co-expression analysis and target gene prediction revealed the strong correlation between MYH7 and NR_126491.1 as well as MYOD1 and ENST00000524479. Moreover, the differential expressions of lncRNAs (XR_001739409.1, NR_024160.1 and XR_001738373.1) and mRNAs (CDKN1A, MYOG, MYOD1, MYBPH, TMEM64, STATH, and MYL3) were validated by RT-qPCR. ROC curve analysis showed that lncRNAs (XR_001739409.1, NR_024160.1, and NR_002766.2) and mRNAs (CDKN1A, MYOG, MYOD1, MYBPH, TMEM64, and STATH) might be promising biomarkers of ONP.ConclusionsThese results may shed light on the molecular biology of EOMs of ONP, as well as the possible correlation of lncRNAs and mRNAs with clinical practice.