bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the sensory properties and consumer acceptance of warm climate red wine through blending
Authors: Espinase Nandorfy Damian , Likos Desireé , Lewin Simone , Barter Sheridan , Kassara Stella , Wang Shaoyang , Kulcsar Allie , Williamson Patricia , Bindon Keren , Bekker Marlize , Gledhill John , Siebert Tracey , Shellie Robert A. , Keast Russell , Francis Leigh 
Published: October 2023

Proline has recently been found to direct several sensory attributes in red wine, including viscosity, fruit flavour and sweetness. We sought to investigate whether a red wine, deemed ‘flavour deficient’ by a producer, from a warm inland region could be improved by blending with a high proline wine from the same region, compared to a high colour and flavour wine, linking consumer acceptance with sensory properties and chemical composition. Three dry red wines (two Cabernet-Sauvignon wines from a warm region and one Lagrein wine from a cooler region) were blended in a constrained mixture design. Several blends were uncovered with improved sensory properties and consumer liking scores. Increased liking scores were related to heightened perceived Viscosity (unrelated to physical viscosity), Sweetness and Berry flavours, connected to proline-rich wines with small proportions of Lagrein. PLS-R models relating blend chemical composition, sensory properties and consumer acceptance associated Astringency and Bitterness to polyphenolics and organic acids and lower liking scores. Vegetal and Leather aromas in blends also reduced consumer acceptance and were related to the concentration of the thiols 3SH, 3SHA, PMT, 2FMT and MeSH, as well as guaiacol and isobutyl methoxypyrazine. Multiple blends successfully improved consumer acceptance of the ‘flavour deficient’ wine, particularly those with an increased proportion of the proline-rich wine. Non-linear effects resulting from blending were also assessed, with most variables modelled best by linear averaging. This study demonstrates the practical application of a design of experiment approach using sensory properties, proline and polyphenolic concentrations to guide wine blending and improve wine flavour and acceptability.
Pesquisas na Universidade Federal do Tocantins e a Revista Desafios
Authors: Nascimento Guilherme Nobre L. do , Pimenta Raphael Sanzio , Sousa Poliana Macedo de , Nascimento Guilherme Nobre L. do , Pimenta Raphael Sanzio , Sousa Poliana Macedo de 
Published: October 2023

A Universidade Federal do Tocantins (UFT) iniciou suas atividades em maio de 2003 (PDI-UFT, 2015) e a o longo destes anos foram criados cursos de graduação e pós-graduação nas diferentes áreas do conhecimento contando hoje com mais de 18.000 alunos, 1.029 professores e 854 técnicos-administrativos.
Atualmente, a UFT está classificada no ranking do Guia do Estudante como uma das melhores Universidades da região norte (Guia do estudante, 2016). Concentrando mais de 85% do total dos doutores cadastrados na Plataforma Lattes no Estado do Tocantins que estão em atividade de Ensino, Pesquisa e Extensão (Plataforma Lattes,2016) o que conferea mesma, grande potencial para auxiliar o desenvolvimento científico e social do Estado. Conta com parcerias importantes tanto nacionais como internacionais.
Attenuation of Neuronal Tissue Damage in Ischemic Stroke by Tat-NR2Bct-CTM and Tat-NR2B9c
Authors: Benedictus Benedictus , Tan Kenneth , Pratama Vincent Kurniawan Putra , Sulastyo Jonathan Daniel 
Published: October 2023

Background: Worldwide, stroke accounts for 15 million cases annually. Despite improved understanding of its pathophysiology, an effective treatment is yet to be available. This review aims to expound ischemic stroke pathophysiology from a bio-molecular perspective, and present two peptides, namely Tat-NR2B9c and Tat-NR2Bct-CTM, which has been proven to attenuate neuronal tissue damage in ischemic stroke.
Methods: Scoping review of several electronic databases: PubMed, Medline, Researchgate, NCBI, SpringerLink, and Google scholar. Search query included: ischemic stroke, NR2B, DAPK1, nNOS, NOX, Tat-NR2Bct-CTM and Tat-NR2B9c.
Results: It is recognizable in a sense, that the pathophysiology pivots on the NR2B-DAPK1 and PSD-95-NR2B interactions. Tat-NR2Bct-CTM and Tat-NR2B9c thwarts NR2B-DAPK1 and PSD-95-NR2B interactions, respectively. These peptides show significant reliability, with the former capable of reducing free DAPK1 by 92,85%, and the latter, the first stroke treatment in two decades to reach Phase 3 clinical trials.
Conclusion: These results strongly support Tat-NR2Bct-CTM and Tat-NR2B9c as effective means to reduce neuronal tissue damage in ischemic stroke.
Characteristics Of Ocular Fundus In Brain Infections At Cipto Mangunkusumo Hospital Jakarta
Authors: Purba Maria Jheny Fulgensia , Pradita Sari  , Septiana Andri Wardana  , Ni Nengah Rida Ariarini  , Kartika Maharani  , Darma Imran  , Riwanti Estiasari  
Published: October 2023

Background: Brain infections (BI) may cause optic nerve abnormalities. Awareness on optic nerve abnormalities will be useful in assisting further management. The characteristics of the ocular fundus (fundus) in BI have not been widely studied in Indonesia. This study aims to apprehend the depiction of the fundus in BI in Cipto Mangunkusumo Hospital Jakarta (RSCM).
Methods: Cross-sectional study conducted on October-December 2021 at RSCM. Images from 20D-lens fundoscopy were captured with a digital camera. Results are analyzed if there are similarities between at least two examiners.
Results: There were 49 subjects whose fundoscopy results could be analyzed. A total of 25 subjects has normal fundus. Abnormalities were seen in 8 subjects, which comprised of 4 (12.1%) papilledema, 3 (9.1%) papillatrophy and 1 (3%) retinal haemorrhage. The highest mean aperture pressure was found in the papillatrophy group (37cmH2O), followed by papilledema (27cmH2O).
Discussion: BI can increase intracranial pressure (ICP). Nonetheless, we found only 12.1% had papilledema. The highest mean aperture pressure was found in the papillatrophy group which showed an increase in ICP over a long period of time. The highest mortality was found in the normal fundus group so that papilledema cannot be directly associated with a worse prognosis considering the uncontrolled confounding factors such as other BI complications.
Conclusion: Although BI causes an increase in ICP, papilledema is not always found. High aperture pressure was found in the papillatrophy group, but the highest mortality was found in the normal fundus group.
Outcomes of Humeral Allograft-Prosthetic Composites with Plate Fixation in Revision Total Elbow Arthroplasty
Authors: Cheema Adnan N. , Conyer Ryan T. , Triplet Jacob J. , O’Driscoll Shawn W. , Morrey Mark E. , Sanchez-Sotelo Joaquín 
Published: October 2023

Background:
Traditionally, the reconstruction of severe distal humeral bone loss at the time of revision total elbow arthroplasty (TEA) has used allograft-prosthetic composites (APCs) stabilized with cerclage wires or cables. We have migrated to plate fixation when revision TEA using a humeral APC is performed. This study shows the outcomes of patients treated with a humeral APC with plate fixation during revision TEA.

Methods:
Between 2009 and 2019, 41 humeral APCs with plate fixation of distal humeral allograft to the native humerus were performed in the setting of revision TEA. There were 12 male patients (29%) and 29 female patients (71%), with a mean age of 63 years (range, 41 to 87 years). The mean allograft length was 12 cm. All elbows had a minimum follow-up of 2 years (mean follow-up, 3.3 years). Patients were evaluated for visual analog scale pain scores, range of motion, the ability to perform select activities of daily living, and the Mayo Elbow Performance Score (MEPS). Outcomes including reoperations, complications, and revisions were noted. The most recent radiographs were evaluated for union at the allograft-host interface, failure of the plate-and-screw construct, or component loosening.

Results:
The mean postoperative flexion was 124° (range, 60° to 150°) and the mean postoperative extension was 26° (range, 0° to 90°); the mean arc of motion was 99° (range, 30° to 150°). The mean MEPS was 58 points (range, 10 to 100 points). Two surgical procedures were complicated by neurologic deficits. The overall reoperation rate was 14 (34%) of 41. Of the 33 patients with complete radiographic follow-up, 12 (36%) had evidence of nonunion at the allograft-host interface with humeral component loosening, 1 (3%) had evidence of partial union, and 1 (3%) had ulnar stem loosening.

Conclusions:
Revision TEA with a humeral APC using compression plating was successful in approximately two-thirds of the elbows. Further refinement of surgical techniques is needed to improve union rates in these complex cases.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Patient-Individualized Identification of Medial Patellofemoral Ligament Attachment Site to Femur Using “CLASS” MRI Sequences
Authors: Uso Marc Barrera , Thürig Grégoire , Heimann Alexander Frank , Schwab Joseph M. , Panadero-Morales Raul , Peris José Luis , Tannast Moritz , Petek Daniel 
Published: October 2023

Background:
Malposition of the femoral tunnel during medial patellofemoral ligament (MPFL) reconstruction may increase the risk of recurrence of patellar dislocation due to isometric changes during flexion and extension. Different methods have been described to identify the MPFL isometric point using fluoroscopy. However, femoral tunnel malposition was found to be the cause of 38.1% of revisions due to patellar redislocation. This high rate of malposition has raised the question of individual anatomical variability.

Methods:
Magnetic resonance imaging (MRI) was performed on 80 native knees using the CLASS (MRI-generated Compressed Lateral and anteroposterior Anatomical Systematic Sequence) algorithm to identify the femoral MPFL insertion. The insertions were identified on the MRI views by 2 senior orthopaedic surgeons in order to assess the reliability and reproducibility of the method. The distribution of the MPFL insertion locations was then described in a 2-plane coordinate system and compared with MPFL insertion locations identified with other methods in previously published studies.

Results:
The CLASS MPFL footprint was located 0.83 mm anterior to the posterior cortex (line 1) and 3.66 mm proximal to the Blumensaat line (line 2). Analysis demonstrated 0.90 and 0.89 reproducibility and 0.89 and 0.80 reliability of the CLASS method to identify the anatomical femoral MPFL insertion point. The distribution did not correlate with previously published data obtained with other methods. The definitions of the MPFL insertion point in the studies by Schöttle et al. and Fujino et al. most closely approximated the CLASS location in relation to the posterior femoral cortex, but there were significant differences between the CLASS method and all 4 previously published methods in relation to the proximal-distal location. When we averaged the distances from line 1 and line 2, the method that came closest to the CLASS method was that of Stephen et al., followed by the method of Schöttle et al.

Conclusions:
The CLASS algorithm is a reliable and reproducible method to identify the MPFL femoral insertion from MRI views. Measurement using the CLASS algorithm shows substantial individual anatomical variation that may not be adequately captured with existing measurement methods. While further research must target translation of this method to clinical use, we believe that this method has the potential to create a safe template for sagittal fluoroscopic identification of the femoral tunnel during MPFL surgical reconstruction.

Level of Evidence:
Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Pemetaan Persebaran Kualitas Air Sungai Irigasi pada Lahan Pertanian di Lereng Karst Gunung Sadeng Kecamatan Puger Kabupaten Jember
Authors: Vivi Ratna Ayuningrum  , Yushardi  , Elan Artono Nurdin  , Sri Astutik  , Fahrudi Ahwan Ikhsan  
Published: October 2023

Perairan pada suatu wilayah perlu mendapatkan akurasi identifikasi kualitas air yang sesuai dengan standar keperluan dalam pemanfataan penggunaannya. Tujuan penelitian untuk: (1) mengkaji persebaran kualitas air sungai irigasi pada lahan pertanian di lereng karst Gunung Sadeng Kecamatan Puger, Kabupaten Jember; (2) mengetahui pemetaan persebaran kualitas air sungai irigasi pada lahan pertanian di lereng karst Gunung Sadeng Kecamatan Puger, Kabupaten Jember. Penelitian ini merupakan jenis penelitian kuantitatif menggunakan metode survey yang digunakan untuk tahapan pengambilan dan pengukuran sampel air sungai irigasi pada area lahan pertanian di lereng karst Gunung Sadeng Kecamatan Puger, Kabupaten Jember. Teknik pengumpulan data yang dilakukan dalam penelitian berupa survey, pengukuran untuk data primer, uji laboratorium dan dokumentasi. Analisis data menggunakan metode IKA-NSF untuk penentuan kategori kualitas air sungai irigasi, metode deskriptif untuk identifikasi kondisi tanah dan pemetaan menggunakan software ArcGIS. Hasil pengukuran kualitas air menunjukkan terdapat indikator sampel yang melebihi batas mutu air yang direkomendasikan untuk pengairan irigasi. Hal tersebut cukup mempengaruhi kualitas air, sedangkan untuk kondisi tanah yang merupakan parameter pendukung menunjukkan hasil yang baik. Pemetaan persebaran kualitas air lokasi penelitian menujukkan hasil yang merata dengan indeks kategori kualitas air yang sedang.
Evaluasi Morfometrik dan Conception Rate (CR) Kambing PE yang di Inseminasi dengan Semen Pejantan Boer
Authors: Kentjonowaty Inggit , Sholikah Nisa’us , Humaidah Nurul , Puspitarini Oktavia Rahayu , Mardhotilah Achmad Bagus Adhiluhung , Mahardhika Brahmadhita Pratama 
Published: October 2023

Tujuan dilaksanakannya penelitian ini untuk melakukan seleksi kambing PE sebagai induk yang akan dikawinkan melalui inseminasi buatan dengan semen kambing Boer melalui evaluasi morfometrik di Sleman, Yogyakarta. Objek dalam penelitian ini adalah induk kambing PE sebanyak 24 ekor. Pada penelitian ini dilakukan analisa regresi dan korelasi untuk mencari hubungan antara panjang badan, lingkar dada, lingkar perut, dan tinggi badan kambing PE betina terhadap bobot badannya. Setelah itu, kambing PE diinseminasi dengan semen pejantan Boer untuk mendapatkan informasi Conception rate nya. Hasil penelitian ini menjukkan bahwa panjang badan, lingkar dada, lingkar perut dan tinggi badan kambing PE berkorelasi dengan bobot badannya. Hubungan antara panjang badan, lingkar dada, lingkar perut kambing PE dengan Bobot badannya sangat erat dengan nilai koefisien korelasi R2 masing-masing 0,75; 0,75 dan 0,72 sedangkan hubungan antara tinggi badan dengan bobot badan tergolong erat yaitu dengan nilai koefisein korelasi R2 sebesar 0,50. Conseption rate hasil perkawinan kambing PE dengan pejantan Boer melalui inseminasi buatan pada peneltian ini sebesar 45,83%. Kesimpulan dari penelitian ini adalah terdapat keeratan hubungan yang tinggi antara mofometrik dan bobot badan induk kambing PE dengan keberhasilan kebuntingan sebesar 45,83%.
Double-blind, randomized, placebo-controlled clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenic auditory hallucinations
Authors: Liu Shuang , Wang Xiaojuan , Zhang Xiaochen , Chang Yuan , Liao Jingmeng , Ming Dong 
Published: October 2023

Abstract

Gamma oscillations are essential for communication between brain regions, and 40Hz neural oscillation defects in schizophrenia. Due to the impaired functional connectivity of the left frontotemporal region, the information communication and integration between the frontal lobe and the temporo-parietal region of schizophrenia are faulty, thus produce auditory hallucinations. Homophasic transcranial alternating current stimulation is thought to enhance connectivity between different brain regions by modulating brain oscillations. In this work, we applied a frontal-temporal-parietal 40Hz-tACS stimulation strategy for treating auditory hallucinations and further explored the effect of tACS on functional connectivity of brain networks. 32 schizophrenia patients with refractory auditory hallucinations received 20 daily 20-min, 40Hz, 1-mA sessions of active or sham tACS on weekdays for 4 consecutive weeks, followed by a 2-week follow-up period without stimulation.Auditory hallucination symptom scores and 64-channel electroencephalograms were measured at baseline, week2, week4 and follow-up. For clinical symptom score, we observed a significant interaction between group and time for auditory hallucinations symptoms (F(3,90) = 26.964, p༜0.001), and subsequent analysis showed that the 40Hz-tACS group had a higher symptom reduction rate than the sham group at week4 (p = 0.036) and follow-up (p = 0.047). EEG results showed that, the 40Hz-tACS group had higher functional connectivity in the right and left frontal (F (1, 30) = 4.15, p = 0.051), right frontal to parietal (F (1, 30) = 7.24, p = 0.012), right frontal to occipital (F (1, 30) = 7.98, p = 0.008) and right intrafrontal (F (1, 30) = 4.13, p = 0.051) than the sham group at week4. Further, functional brain network controllability outcomes showed that the 40Hz-tACS group had increased average controllability (F (1, 30) = 6.26, p = 0.018) and decreased modality controllability (F (1, 30) = 6.50, p = 0.016) in the right frontal lobe compared to the sham group. Our study indicates that 40Hz-tACS may be an effective treatment for targeting symptoms specific to auditory hallucinations and altering functional connectivity and controllability at the network level.
Evaluating the association between placenta DNA methylation and cognitive functions in the offspring
Authors: Cosin-Tomas Marta , Diez-Ahijado Laia , Cislleros-Portet Ariadna , Fernández-Jimenez Nora , Fernández Mariana F. , Guxens Mònica , Julvez Jordi , Llop Sabrina , Lopez-Espinosa Maria-Jose , Subiza Mikel , Lozano Manuel , Ibarluzea Jesus , Sunyer Jordi , Bustamante Mariona , Cosin-Tomas Marta 
Published: October 2023

Abstract

Placenta plays a crucial role protecting the foetus from environmental harm and supports the development of its brain. In fact, compromised placental function could predispose an individual to neurodevelopmental disorders. Placental epigenetic modifications, including DNA methylation, could be considered a proxy of placental function and thus plausible mediators of the association between intrauterine environmental exposures and genetics, and childhood and adult mental health. Although neurodevelopmental disorders such as autism spectrum disorder have been investigated in relation to placenta DNA methylation, no studies have addressed the association between placenta DNA methylation and child’s cognitive functions. Thus, our goal here was to investigate whether placental DNA methylation profile measured using the Illumina EPIC array is associated with three different cognitive domains (namely verbal score, perceptive performance score, and general cognitive score) assessed by the McCarthy Scales of Children’s functions in childhood at age 4. To this end, we conducted epigenome-wide association analyses including data from 255 mother-child pairs within the INMA project and performed a follow-up functional analysis to help the interpretation of the findings. After multiple-testing correction, we found that methylation at 4 CpGs (cg1548200, cg02986379, cg00866476 and cg14113931) was significantly associated with the general cognitive score, and 2 distinct differentially methylated regions (DMRs) (including 27 CpGs) were significantly associated with each cognitive dimension. Interestingly, the genes annotated to these CpGs were involved in placenta, foetal, and brain development. Moreover, functional enrichment analyses of suggestive CpGs (p < 1x10− 4) revealed gene-sets involved in placenta development, foetus formation and brain growth. These findings suggest that placental DNAm could be a mechanism contributing to the alteration of important pathways in the placenta that have a consequence on the offspring’s brain development and cognitive function. .
Inferring molecular Inhibition potency with AlphaFold predicted structures
Authors: Falcao Andre , Oliveira Pedro , Guedes Rita 
Published: October 2023

Abstract
Even though in silico drug ligand-based methods have been successful in predicting interactions with known target proteins, they struggle with new, unassessed targets. To address this challenge, we propose an innovative approach that integrates structural data from AlphaFold 2-predicted protein structures into machine learning models. Our method extracts 3D structural protein fingerprints and combines them with ligand structural data to train a single machine learning model. This model captures the relationship between ligand properties and the unique structural features of various target proteins, enabling predictions for novel molecules and protein targets. To assess our model, we used a dataset of 144 Human G-protein Coupled Receptors (GPCRs) with over 140,000 measured inhibition constants (Ki) values. Our results demonstrate that our approach performs as well as state-of-the-art ligand-based methods, even for previously unencountered targets. In a test set of 15 protein targets with removed Ki information from the training data, our model predicted interactions for 73% of targets, with explained variances exceeding 0.50 in 22% of cases. In conclusion, our study presents an in silico drug development approach that bridges the gap between ligand-based methods and structural data integration for predicting protein-molecule interaction even for orphan targets.