bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Theranostic Optimization of PSMA-GCK01 Does Not Compromise the Imaging Characteristics of [99mTc]Tc-PSMA-GCK01 Compared to Dedicated Diagnostic [99mTc]Tc-EDDA/HYNIC-iPSMA in Prostate Cancer
Authors: Mamlins Eduards , Scharbert Lara , Cardinale Jens , Krotov Maria , Winter Erik , Rathke Hendrik , Strodel Birgit , Ankrah Alfred O. , Sathekge Mike , Haberkorn Uwe , Kratochwil Clemens , Giesel Frederik L. 
Published: December 2023

Abstract
Purpose
Radiolabeled PSMA-ligands play a major role in today’s nuclear medicine. Since approval of [177Lu]Lu-PSMA-617 for therapy of metastatic prostate cancer, availability of 177Lu became bottleneck of supply due to the high demand. Recently, a theranostic PSMA-ligand, PSMA-GCK01, was developed which can be labeled either diagnostically with 99mTc or therapeutically with 188Re with both nuclides available from well-known generator systems. This novel tracer might aid to overcome aforementioned supply limitations. In this investigation, the biodistribution and general imaging characteristics of [99mTc]Tc-PSMA-GCK01 were compared with the diagnostic reference compound [99mTc]Tc-EDDA/HYNIC-iPSMA in patients with advanced stage prostate cancer. In addition, the binding of both ligands to PSMA was analyzed at the molecular level using molecular docking.

Procedures
Two cohorts (n = 19 vs. n = 21) of patients with metastatic castration-resistant prostate cancer matched for age, tumor stage, and Gleason score underwent a planar gamma camera imaging with [99mTc]Tc-EDDA/HYNIC-iPSMA or [99mTc]Tc-PSMA-GCK01 prior to PSMA-ligand therapy for PSMA-phenotyping. The imaging data were retrospective analyzed for salivary gland, kidney, liver, soft tissue, and tumor uptake on a semi-automated ROI-analysis using HERMES Medical Solutions AB (HMS, Sweden).

Results
The data sets were semi-automated quantified on a ROI-based analysis. The tumor-to-background presented equal results of [99mTc]Tc-PSMA-GCK01 compared to [99mTc]Tc-EDDA/HYNIC-iPSMA. The physiological PSMA-positive organs like salivary gland presented also equal uptake in counts/MBq (salivary gland median 9.48 [99mTc]Tc-PSMA-GCK01 vs. median 9.11 [99mTc]Tc-EDDA/HYNIC-iPSMA), while liver-to-kidney ratio presented a slight shift to the liver parenchyma using [99mTc]Tc-PSMA-GCK01 (0.83) compared to [99mTc]Tc-EDDA/HYNIC-iPSMA (0.55) with no statistical significance. This is in agreement with the results from the docking study revealing only a minor difference in the docking scores for both ligands.

Conclusions
The novel theranostic tracer [99mTc]Tc/[188Re]Re-PSMA-GCK01 demonstrates comparable general imaging characteristic with the reference compound [99mTc]Tc-EDDA/HYNIC-iPSMA. These results pave the way for the PSMA-targeting imaging and theranostic agents for a broader, rather low-cost, generator applied radio-ligand therapy utilization.
Phyllite/bentonite mixture—an alternative effective buffer material for a geological disposal of radioactive waste
Authors: Kyzioł-Komosińska Joanna , Janeczek Janusz , Dzieniszewska Agnieszka , Fabiańska Monika J. , Matuszewska Aniela , Teper Ewa , Szram Ewa , Krzykawski Tomasz , Pająk Magdalena , Czupiol Justyna 
Published: December 2023

AbstractThe use of phyllite (Phy) instead of quartz in mixtures with bentonite (B) is recommended as a buffer material for engineering barriers in a geological repository of nuclear waste. The recommendation is based on experimentally determined sorption properties of various Phy/B mixtures. The adsorption capacity of Phy/B mixtures (Phy/B: 75/25, 50/50, and 25/75), the removal efficacy of Eu(III) ions (an analog for fissiongenic lanthanides and actinides), and the rate of their binding reaction were studied using the batch adsorption equilibrium and kinetic experiments at different Eu(III) initial concentrations, solution pH, and solution to adsorbent (L/S) ratio. The adsorption capacity of the Phy/B mixtures increased with the increased bentonite content in the mixture depending on the L/S ratio and solution pH. The highest increase in the adsorption capacity of the Phy/B mixtures compared to phyllite was observed for the Phy/B proportions of 25/75 and 50/50. The rate of the Eu(III) adsorption was the best fitted by the pseudo-second-order kinetic model indicating that the adsorption rate was controlled by chemisorption. The Sips model provided the best correlation of the adsorption experimental data, indicative of more than one adsorption site. The results of this study show the advantage of the Phy/B mixtures in immobilizing Eu and certain fission products by combining adsorption properties of the materials.
Effective microorganism water treatment method for rapid eutrophic reservoir restoration
Authors: Tomczyk Paweł , Wierzchowski Paweł Stanisław , Dobrzyński Jakub , Kulkova Iryna , Wróbel Barbara , Wiatkowski Mirosław , Kuriqi Alban , Skorulski Witold , Kabat Tomasz , Prycik Mirosław , Gruss Łukasz , Drobnik Jarosław 
Published: December 2023

AbstractSince reservoirs perform many important functions, they are exposed to various types of unfavorable phenomena, e.g., eutrophication which leads to a rapid growth of algae (blooms) that degrade water quality. One of the solutions to combat phytoplankton blooms are effective microorganisms (EM). The study aims to evaluate the potential of EM in improving the water quality of the Turawa reservoir on the Mała Panew River in Poland. It is one of the first studies providing insights into the effectiveness of using EM in the bioremediation of water in a eutrophic reservoir. Samples for the study were collected in 2019–2021. The analysis showed that EM could be one of the most effective methods for cleaning water from unfavorable microorganisms (HBN22, HBN36, CBN, FCBN, FEN) — after the application of EM, a reduction in their concentration was observed (from 46.44 to 58.38% on average). The duration of their effect ranged from 17.6 to 34.1 days. The application of EM improved the trophic status of the Turawa reservoir, expressed by the Carlson index, by 7.78%. As shown in the literature review, the use of other methods of water purification (e.g., constructed wetlands, floating beds, or intermittent aeration) leads to an increase in the effectiveness and a prolongation of the duration of the EM action. The findings of the study might serve as a guide for the restoration of eutrophic reservoirs by supporting sustainable management of water resources. Nevertheless, further research should be conducted on the effectiveness of EM and their application in the remediation of eutrophic water reservoirs.
Towards Inferring Network Properties from Epidemic Data
Authors: Kiss Istvan Z. , Berthouze Luc , KhudaBukhsh Wasiur R. 
Published: December 2023

AbstractEpidemic propagation on networks represents an important departure from traditional mass-action models. However, the high-dimensionality of the exact models poses a challenge to both mathematical analysis and parameter inference. By using mean-field models, such as the pairwise model (PWM), the high-dimensionality becomes tractable. While such models have been used extensively for model analysis, there is limited work in the context of statistical inference. In this paper, we explore the extent to which the PWM with the susceptible-infected-recovered (SIR) epidemic can be used to infer disease- and network-related parameters. Data from an epidemics can be loosely categorised as being population level, e.g., daily new cases, or individual level, e.g., recovery times. To understand if and how network inference is influenced by the type of data, we employed the widely-used MLE approach for population-level data and dynamical survival analysis (DSA) for individual-level data. For scenarios in which there is no model mismatch, such as when data are generated via simulations, both methods perform well despite strong dependence between parameters. In contrast, for real-world data, such as foot-and-mouth, H1N1 and COVID19, whereas the DSA method appears fairly robust to potential model mismatch and produces parameter estimates that are epidemiologically plausible, our results with the MLE method revealed several issues pertaining to parameter unidentifiability and a lack of robustness to exact knowledge about key quantities such as population size and/or proportion of under reporting. Taken together, however, our findings suggest that network-based mean-field models can be used to formulate approximate likelihoods which, coupled with an efficient inference scheme, make it possible to not only learn about the parameters of the disease dynamics but also that of the underlying network.
Soil bacterial and fungal communities resilience to long-term nitrogen addition in subtropical forests in China
Authors: Fu Xinlei , Dai Yunze , Cui Jun , Deng Pengfei , Fan Wei , Xu Xiaoniu 
Published: December 2023

AbstractAtmospheric nitrogen (N) deposition is predicted to increase, especially in the subtropics. However, the responses of soil microorganisms to long-term N addition at the molecular level in N-rich subtropical forests have not been clarified. A long-term nutrient addition experiment was conducted in a subtropical evergreen old-growth forest in China. The four treatments were: control, low N (50 kg N ha−1 a−1), high N (100 kg N ha−1 a−1), and combined N and phosphorus (P) (100 kg N ha−1 a−1 + 50 kg P ha−1 a−1). Metagenomic sequencing characterized diversity and composition of soil microbial communities and used to construct bacterial/fungal co-occurrence networks. Nutrient-treated soils were more acidic and had higher levels of dissolved organic carbon than controls. There were no significant differences in microbial diversity and community composition across treatments. The addition of nutrients increased the abundance of copiotrophic bacteria and potentially beneficial microorganisms (e.g., Gemmatimonadetes, Chaetomium, and Aureobasidium). Low N addition increased microbiome network connectivity. Three rare fungi were identified as module hubs under nutrient addition, indicating that low abundance fungi were more sensitive to increased nutrients. The results indicate that the overall composition of microbial communities was stable but not static to long-term N addition. Our findings provide new insights that can aid predictions of the response of soil microbial communities to long-term N addition.
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
Authors: Zhang Xusheng , Chen Bendong , Liu Kejun , Ma Yongxin , Liu Yimin , Zhou Hongcai , Wei Peng 
Published: December 2023

Abstract
Objective
To investigate the effect of COVID-19 infection on pancreatic cancer.

Methods
Based on the mRNA-Seq data of COVID-19 patients and pancreatic cancer (PC) patients in the GEO database, we used a support vector machine (SVM), LASSO-Cox regression analysis and random forest tree (RF) to screen the common signature genes of the two diseases and further investigate their effects and functional characteristics on PC, respectively. The above procedures were performed in R software.

Results
The proteins COL10A1/FAP/FN1 were found to be common signature genes for COVID-19 and PC, were significantly up-regulated in both diseases and showed good diagnostic efficacy for PC. The risk model based on COL10A1/FAP/FN1 showed good PC risk prediction ability and clinical application potential. Tumor typing based on COL10A1/FAP/FN1 expression levels effectively classified PC into different subtypes and showed significant differences between the two subtypes in terms of survival prognosis, immune levels, immune checkpoint expression levels, mutation status of common tumor mutation sites, and drug sensitivity analysis. While pathway analysis also revealed that FN1 as an extracellular matrix component may be involved in the biological process of PC by regulating the PI3K-AKT signaling axis.

Conclusion
The upregulated expression of COL10A1/FAP/FN1, the characteristic genes of COVID-19, are potential diagnostic targets for PC, and the upregulated expression of FN1 may promote the progression of PC by activating the PI3K-AKT signaling pathway. The COL10A1/FAP/FN1-based typing provides a new typing approach for PC, and also provides a good reference and idea for the refinement of PC treatment and subsequent clinical research.
Vertical height growth mechanism of hydraulic fractures in laminated shale oil reservoirs based on 3D discrete lattice modeling
Authors: Chang Xin , Wang Xingyi , Yang Chunhe , Guo Yintong , Wei Kai , Li Qiang , Jiang Chengbai 
Published: December 2023

AbstractBedding planes are abundant in shale oil reservoirs, but the intrinsic mechanism of fracture-height containment by these weak interfaces remains unclear. To investigate the effects of interface properties, stress conditions, and fracturing fluid viscosity on the vertical propagation of fracture heights in laminated shale oil reservoirs, a three-dimensional hydro-mechanical coupling numerical model was developed. The model is based on the 3D discrete lattice algorithm (DLA), which replaces the balls and contacts in the conventional synthetic rock mass model (SRM) with a lattice consisting of spring-connected nodes, resulting in improved computational efficiency. Additionally, the interaction between hydraulic fractures and bedding planes is automatically computed using a smooth joint model (SJM), without making any assumptions about fracture trajectories or interaction conditions. The results indicate that a higher adhesive strength of the laminated surface promotes hydraulic fracture propagation across the interface. Increasing the friction coefficient of the laminated surface from 0.15 to 0.91 resulted in a twofold increase in the fracture height. Furthermore, as the difference between vertical and horizontal principal stresses increased, the longitudinal extension distance of the fracture height significantly increased, while the activated area of the laminar surface decreased dramatically. Moreover, increasing the viscosity of the fracturing fluid led to a decrease in filtration loss along the laminar surface of the fracture and a rapid increase in net pressure, making the hydraulic fracture more likely to cross the laminar surface directly. Therefore, for heterogeneous shale oil reservoirs, a reverse-sequence fracturing technique has been proposed to enhance the length and height of the fracture. This technique involves using a high-viscosity fracturing fluid to increase the fracture height before the main construction phase, followed by a low-viscosity slickwater fracturing fluid to activate the bedding planes and promote fracture complexity. To validate the numerical modeling results, five sets of laboratory hydraulic fracturing physical simulations were conducted in Jurassic terrestrial shale. The findings revealed that as the vertical stress difference ratio increased from 0.25 to 0.6, the vertical fracture area increased by 1.98 times. Additionally, increasing both the injection displacement and the viscosity of the fracturing fluid aided in fracture height crossing of the laminar facies. These results from numerical simulation and experimental studies offer valuable insights for hydraulic fracturing design in laminated shale oil reservoirs.
Letting the plants speak: Law, landscape and conservation
Authors: Gillespie Jo , Hamilton Rebecca , Penny Dan 
Published: December 2023

AbstractThe Botany Wetlands are the contemporary remnant of a formerly extensive coastal freshwater wetland in the inner-urban suburbs of Sydney (Australia). This site supports a range of ecosystem services, including human physical and mental health benefits, filtration of stormwater runoff from a highly urban and industrial catchment, and accommodation space for floodwater. The wetlands also provide habitat to migratory water birds and act as a connective habitat corridor and refuge for native flora and fauna including endangered ecological communities recognised in state and national legislation. Current management strategies and ‘on the ground’ practices are informed by a hierarchy of laws and management plans that act to create and reinforce a specific narrative in the material landscape. Here we consider the ecological history of the wetlands, derived from paleoecological data, in the context of this complex network of governance entanglements. We argue that the system bears little resemblance to its long-term character and has been made and continually re-made by a portmanteau of inflexible regulatory structures. We suggest that maintaining ecosystem services in such a complex, hybridized sociolegal-biophysical system requires a critical view of both the power relationsandphysical processes that shape it.
“I Thought you had Forgotten me”: A Corpus-Pragmatic Examination of the Mental Verb Think in Irish Emigrants’ Letters
Authors: Ávila-Ledesma Nancy E. 
Published: December 2023

AbstractThis paper sets out to explore the interface between migration experiences and epistolary discourse in CORIECOR, the Corpus of Irish English Correspondence (McCafferty and Amador-Moreno in preparation). Using corpus and computational methods, this investigation aims to empirically explore language usage in the letters exchanged between the Irish in the United States of America, Australia and New Zealand and their loved ones back in Ireland. Specifically, the study proposes a corpus-pragmatic examination of the mental verb think in an attempt to explain the function of such verb in the negotiation of epistolary relationships, that is, how it helps to reinforce and maintain crucial emotional and physical links between emigrants and their families in Ireland. The material will be searched using Sketch Engine (Kilgarriff et al. 2004). In the quantitative stage, corpus tools such as the Corpus Query Language (CQL) function will be utilised to identify and collect the linguistic patterns that characterise the epistolary discourse under analysis. Qualitatively, a detailed inspection of such patterns will be conducted in order to provide access to historical forms of communication in the context of nineteenth- and twentieth-century Irish emigration as well as the use of involvement-marking strategies in private letters.
Greenup Variability Impact on Seasonal Streamflow and Soil Moisture Dynamics in Humid, Temperate Forests
Authors: Hwang Taehee , Band Lawrence E. , Oishi A. Christopher , Kang Hojeong 
Published: December 2023

AbstractIn this study, we investigate how seasonal streamflow and soil moisture patterns have responded to variability in vegetation phenology in humid, temperate forested watersheds without significant seasonal snowmelt over the last four decades. We characterize spring streamflow peaks using 50th percentiles of cumulative daily precipitation, streamflow, and soil moisture measurements, and investigate interactions with remotely sensed, greenup anomalies. After removing a dominant precipitation control, 1‐day earlier greenup is usually associated with about 1‐day early spring flow peak at four low‐elevation deciduous catchments using both sequential and multiple linear regressions. This indicates that the strong dependency of seasonal flow regimes on precipitation is mediated by vegetation seasonality, especially by greenup variability. In contrast, we find less significant correlations of the greenup anomalies on flow percentiles from two paired evergreen and two high‐elevation deciduous catchments. At a plot scale, similar correlations were found only at an upslope topographic position, where precipitation also showed tighter coupling with moisture seasonal patterns than downslope. Our study suggests that rainfall‐runoff and rainfall‐soil moisture relations have been closely mediated by vegetation seasonality in deciduous forests, especially by greenup anomalies, but patterned along topoclimate and hillslope gradients. This study emphasizes that it is important to understand phenological responses to ongoing climate change (in both long‐term and interannual variability) for prediction of seasonal flow regimes especially in deciduous forested catchments.
Remote Sensing of Ocean Dynamics Parameters by Wide‐Beam High‐Frequency Hybrid Sky‐Surface Wave Radar: Localization of Sea Surface Scattering Points and Decontamination of Semi‐Physical Ionosphere Phase
Authors: Feng Mengyan , Fang Hanxian , Wu Xiongbin , Ai Weihua , Yue Xianchang , Zhang Lan 
Published: December 2023

AbstractThis study addresses the issue of locating the scattering points on the sea surface and rectifying the interference caused by the ionosphere phase in the remote sensing of ocean dynamics parameters. Wide‐beam high‐frequency hybrid sky‐surface wave radar (WB‐HFSSWR) was used for this purpose. In order to mitigate the impact of ionosphere phase contamination on the electron density variation along the sky‐wave path of a radio wave, we present two algorithms: the WB‐HFSSWR Single‐Station sea surface scattering point localization algorithm (WB‐SPLA) and the semi‐physical ionosphere phase decontamination algorithm (SP‐IPDA). Compared with the currently employed ionosphere phase decontamination algorithm, the SP‐IPDA algorithm exhibited enhanced physical characteristics. To evaluate the efficacy of the proposed algorithms, we calculate the root‐mean‐square errors (RMSEs) of the elliptical current velocity (vE‐IRI and vE‐GST) of the WB‐HFSSWR, based on the SP‐IPDA and generalized S‐transform algorithm (GST). The results demonstrated that the RMSEs of vE‐IRI and vE‐GST were comparable to the precision of the bistatic surface‐wave radar elliptical current velocity. The data volume of vE‐IRI was 20.5% larger than that of vE‐GST, and vE‐IRI was more precise than vE‐GST, with RMSEs of 11.98 and 12.63 cm/s, respectively. Furthermore, on the common sea surface scattering points, the precision of vE‐IRI was approximately 18.4% higher than that of vE‐GST.
Future Amplification of Multivariate Risk of Compound Drought and Heatwave Events on South Asian Population
Authors: Ullah Irfan , Zeng Xin‐Min , Mukherjee Sourav , Aadhar Saran , Mishra Ashok Kumar , Syed Sidra , Ayugi Brian Odhiambo , Iyakaremye Vedaste , Lv Haishen 
Published: December 2023

AbstractOver the past few decades, South Asia (SA) has experienced an upsurge in the frequency of severe monsoonal compound drought and heatwave (CDHW) occurrences. Climate models that identify land‐atmosphere coupling as a major contributing factor for this exacerbation and anticipate an increase in the intensity and frequency of CDHW occurrences in future also represent this. For the first time, this study investigated the future evolution of monsoonal CDHW events based on new generations of the CMIP6 and population products by applying a multivariate framework. Specifically, this study explored the impacts of natural climate variability and future land‐atmosphere coupling on the monsoonal CDHW event risks and their bivariate return periods for two future time‐periods and emission scenarios across SA and its subregions. The odds of CDHW occurrences were then examined using a logistic regression model and its association with the natural and anthropogenic drivers was determined. The results indicate that the monsoonal CDHWs occurrence is anticipated to increase substantially during the late twenty‐first century (2056–2090). The 50‐year CDHW events might increase by two‐fold across most of SA by the mid‐21st century under the high emission scenario. We find that the co‐occurring dry and warm conditions rapidly strengthens with soil moisture and temperature coupling and are further exacerbated by land‐atmospheric feedback loops. Our findings show that persistent dry spells contribute significantly to heatwave events, emphasizing regional exposure to changing climates.