bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of the Posterior Nasal Nerve Cryoablation in Allergic and Non‐Allergic Rhinitis
Authors: Kim Do Hyun , Kang Yun Jin , Kim Soo Whan , Kim Sung Won , Basurrah Mohammed Abdullah , Hwang Se Hwan 
Published: November 2023

ObjectivesThis study assessed the impact of cryoablation of the posterior nasal nerve on symptoms of rhinitis in individuals with allergic rhinitis (AR) and non‐allergic rhinitis (NAR).Data SourcesPubMed, SCOPUS, Embase, Web of Science, and Cochrane databases for studies published up to June 2023.Review MethodsStudies that evaluated the quality of life and rhinitis‐related symptom scores before and after cryotherapy treatment, as well as sham‐controlled studies, were included.ResultsIn total, 368 patients from seven studies were analyzed. Patients who underwent cryoablation showed a significant improvement in rhinitis‐related symptoms in both NAR and AR. In particular, the most significant improvement was observed in symptoms of rhinorrhea and congestion. Furthermore, cryoablation improved the disease‐specific quality of life evaluated using the Rhinoconjunctivitis Quality of Life Questionnaire. The rate of clinical improvement in the total nasal symptom score (total nasal symptom score [TNSS]; >30% reduction from baseline) after cryotherapy was 74%. The change in TNSS score significantly increased over time in NAR patients (p = 0.0041). Therefore, changes in the TNSS score after 12 months of cryotherapy treatment were greater in the NAR group than in the AR group (p = 0.0020), indicating that cryoablation is effective for both types of rhinitis and has better long‐term efficacy in NAR than in AR.ConclusionsSubjective symptom scores related to rhinitis, particularly for rhinorrhea and congestion, decrease after cryoablation of the posterior nasal nerve. Furthermore, the symptom improvement was greater in NAR than AR. Laryngoscope, 134:2502–2512, 2024
A Systematic Review of Peritonsillar Abscess Simulators: Enhancing Training and Identifying the Need for Standardization
Authors: Marouf Azmi , Doty Samuel , Quereshy Humzah A. , Johnson Benjamin R. , Cabrera Claudia I. , Mowry Sarah , Tamaki Akina 
Published: November 2023

ObjectivesTo systematically review the literature regarding previously described peritonsillar abscess (PTA) drainage simulation.Data SourcesPubMed, Scopus, Web of Science, Ovid, and Cochrane.Review MethodsA search of the abovementioned databases was performed in August 2022 using the terms “peritonsillar abscess/quinsy,” “incision/drainage/aspiration,” and “simulation.” No time restrictions were applied. We included studies that clearly described how their PTA models were built and underwent validation from experts and/or evaluation from trainees. Articles describing a model only without any evaluation and reports in languages other than English were excluded.ResultsOur search initially yielded 80 articles after duplicate removal, 10 of which met our criteria and were included. Two studies trained participants on both needle aspiration and incision and drainage (I&D), four studies on I&D only, and four on needle aspiration only. 87.5% to 100% of junior residents reported minimal exposure to PTA prior to simulation. Five studies provided some form of validation to their models. The value of the simulators to train participants on skills received better appreciation than their anatomical fidelity. The perceived confidence level of trainees in managing PTA, which was assessed in 7 studies, substantially improved after training.ConclusionPTA simulation improves the confidence of trainees to perform PTA drainage. There is, however, a lack of standardization and evidence regarding transfer validity among PTA simulators. The development of a standardized PTA simulator could allow for more widespread use and increase resident comfort with this procedure in a pre‐clinical setting.Level of EvidenceNA Laryngoscope, 134:2495–2501, 2024
Paradox of relatively more phospholipids in phytoplankton in phosphorus limited sea
Authors: Gašparović Blaženka , Vrana Ivna , Frka Sanja , Marić Pfannkuchen Daniela , Vlašiček Ivan , Djakovac Tamara , Ivančić Ingrid , Smodlaka Tanković Mirta , Milinković Andrea , Flanjak Lana , Chaux Frédéric , Novak Tihana , Medić Nikola , Godrijan Jelena 
Published: November 2023

AbstractMarine life is threatened by global warming and its indirect consequences, which include, among others, increased stratification leading to phosphorus (P) and nitrogen depletion in the upper water column. Phosphorus plays a key role in all biochemical systems; storage of metabolic energy, formation of genetic material, and subcellular compartmentalization. Our multi‐year study of lipid biogeochemistry in the northern Adriatic (Mediterranean), which is becoming warmer and nutrient‐poorer, particularly regarding P, has shown that under conditions of P scarcity, phospholipids are relatively more abundant and smaller plankton cells dominate. Consistent with the field data, experiments with seven phytoplankton monocultures, comprising microplankton, nanoplankton, and picoplankton, confirmed a relatively higher phospholipid content in the smaller phytoplankton species and, in particular, an increase in those grown under stress conditions in general, including, unexpectedly, P‐limitation. We suggest two reasons for the observed “P paradox” of P‐limited phytoplankton: (1) cell geometry: volume of the plasma membrane relative to the volume of the entire cell is greater in smaller cells and, therefore, the proportion of plasma membrane phospholipids to intracellular lipids is greater in smaller cells, (2) higher proportion of densely packed saturated fatty acids found in stressful conditions, including P oligotrophy, additionally increase the proportion of membrane phospholipids relative to intracellular lipids. Our findings contribute to the understanding of P cycling in the sea. In addition, our data suggest that higher phospholipid export to deep waters is possible by smaller plankton.
Control of Spectral Extreme Events in Ultrafast Fiber Lasers by a Genetic Algorithm
Authors: Wu Xiuqi , Zhang Ying , Peng Junsong , Boscolo Sonia , Finot Christophe , Zeng Heping 
Published: November 2023

AbstractExtreme wave events or rogue waves (RWs) are both statistically rare and of exceptionally large amplitude. They are observed in many complex systems ranging from oceanic and optical environments to financial models and Bose–Einstein condensates. As they appear from nowhere and disappear without a trace, their emergence is unpredictable and non‐repetitive, which makes them particularly challenging to control. Here, the use of genetic algorithms (GAs), which are exclusively designed for searching and optimizing stationary or repetitive processes in nonlinear optical systems, is extended to the active control of extreme events in a fiber laser cavity. Feeding real‐time spectral measurements into a GA controlling the electronics to optimize the cavity parameters, the wave events are able to be triggered in the cavity that have the typical statistics of RWs in the frequency domain. The intensity of the induced RWs can also be tailored. This accurate control enables the generation of optical RWs with a spectral peak intensity 32.8 times higher than the significant intensity threshold. A rationale is proposed and confirmed by numerical simulations of the laser model for the related frequency up‐ and downshifting of the optical spectrum that are experimentally observed.
Generation and Manipulation of Spin‐Orbit Coupling mode via Four‐Wave Mixing with Quantum Interference
Authors: Pan Churong , Li Huangjie , Pang Hao , Ru Ruibo , Zhang Sannv , Wei Dong , Chen Haixia , Gao Hong , Li Fuli 
Published: November 2023

AbstractRecently, the vectorial nonlinear optical processes driven by spin‐orbit coupling (SOC) light have come to the fore, leading to striking optical phenomena and important applications both in classical and quantum optics. However, research on the SOC‐mediated light‐atom interactions is still in its infancy. Here, the generation and manipulation of SOC mode through a vectorial four‐wave mixing (FWM) process in 85Rb vapor is demonstrated. Under the excitation of two SOC pump beams, multiple FWM paths can be simultaneously established due to the rich atomic Zeeman sublevels coupling with different circularly polarized components of SOC fields. A higher‐order cylindrical or more general SOC FWM signal is observed in the vectorial FWM process, which obeys angular momentum conservation and Gouy phase matching. In particular, quantum interference between different FWM paths plays a crucial role in manipulating the SOC mode of the generated FWM signal, revealing that the conversion of SOC mode is intrinsically quantum. This work provides a pathway toward deeper insight into the vectorial nonlinear optical processes and may advance technology for shaping spatially structured light, which is essential in applications such as nonlinear polarization imaging and the optical communication realm.
Multiple High‐Q Optical Modes in a Polymer‐Lithium Niobate Integrated Metasurface
Authors: Fang Cizhe , Kanyang Ruoying , Ji Yingke , Zhang Yong , Yang Jiayong , Wang Di , Liu Yan , Gan Xuetao , Han Genquan , Hao Yue 
Published: November 2023

AbstractWith the development of miniaturization and integration, multifunctional optical devices are necessary. However, its practical realization is a critical challenge due to the lack of simple structures with multiple functionalities. Here, a multimode metasurface is proposed by simply placing polymer nanocubes on the lithium niobate (LN) thin film. The intriguing properties of the integrated structure include high‐quality (Q) factors and different spectral characteristics, associated with quasi‐guide modes (GM) and Mie modes, respectively. The experiment demonstration reveals that Q factors of four modes are larger than 1000 and a second harmonic generation (SHG) enhancement factor of 25.4 is obtained, featuring strong light‐matter interaction. Importantly, the abundant spectral characteristics greatly boost three degrees of freedom, i.e., polarization, incident angle, and slot, to realize multifunctional designs. The results provide a sophisticated platform for developing high‐performance LN metasurfaces with the advantages of simplified fabrication processes and multifunctionality. The strategy can also be extended to other material systems, enabling the flexibility of metasurface‐inspired subwavelength engineering.
Optimized Charge/Hydrophobicity Balance of Antimicrobial Peptides Against Polymicrobial Abdominal Infections
Authors: Du Kehan , Yang Zhuo‐Ran , Qin Huimin , Ma Teng , Tang Jiawei , Xia Jianxin , Zhou Zengtai , Jiang Hao , Zhu Jintao 
Published: November 2023

AbstractAntimicrobial peptides (AMPs) potentially serve as ideal antimicrobial agents for the treatment of polymicrobial abdominal infections due to their broad‐spectrum antimicrobial activity and excellent biocompatibility. However, the balance of chain length, positive charges, and hydrophobicity on the antimicrobial activity of AMPs are still far from being optimal. Herein, a series of AMPs ([KX]n‐NH2, X = Ile, Leu or Phe, n = 3, 4, 5, or 6) with varied charges and hydrophobicity for the treatment of polymicrobial abdominal infections are designed. Specifically, [KI]4‐NH2 peptide exhibits the best in vitro antimicrobial activity against Gram‐positive and ‐negative bacteria, as well as fungal strains. Based on the good cell biocompatibility, [KI]4‐NH2 peptide is found to have negligible in vivo toxicity at the dosage of up to 28 mg kg−1. Furthermore, great in vivo therapeutic efficacy of [KI]4‐NH2 peptide against S. typhimurium is demonstrated in the mice abdominal infection model. The design of short sequence of antimicrobial peptides with a charge/hydrophobicity balanced structures provides a simple and efficient strategy for potential clinical applications of antimicrobial peptide‐based biomaterials in a variety of bacterial infection diseases.
4D Printing Nanocomposite Hydrogel Based on PNIPAM and Prussian Blue Nanoparticles Using Stereolithography
Authors: Pelluau Tristan , Brossier Thomas , Habib Michel , Sene Saad , Félix Gautier , Larionova Joulia , Blanquer Sébastien , Guari Yannick 
Published: November 2023

AbstractThe potential of photoactive Prussian blue nanoparticles dispersed in thermo‐responsive PNIPAM hydrogels in 4D printing using a stereolithography is investigated with digital light processing. The proportion of Prussian blue nanoparticles used in the resin is chosen to deliver a significant photothermal effect providing a heating above the volume phase transition temperature of the final nanocomposite hydrogels; while, giving only a limited effect on light scattering during the 3D printing process. Four formulations with various amounts of Prussian blue nanoparticles are used to print 3D structures with different shapes, such as Aztec pyramids, cylinders, gyroid porous cubes, and porous films. The shrinkage effect triggered by light irradiation at 808 nm on the as‐obtained nanocomposite hydrogels is demonstrated through the delivery of a representative molecule fluorescein and a triggered 4D shape‐morphing effect.
Observation of Peek Melting Peaks within the Additive Manufacturing Material Extrusion Process in Relation to Isothermal and Non‐Isothermal Processes
Authors: Comelli Cleiton André , Yi Nan , Davies Richard , van der Pol HenkJan , Ghita Oana 
Published: November 2023

AbstractThe current study investigates the melting behavior of polyetheretherketone (PEEK) using both Differential Scanning Calorimetry (DSC) and Fast Scanning Calorimetry (FSC) thermal analysis techniques. The PEEK melting peaks are examined under various conditions, including isothermal and non‐isothermal crystallization conditions, as well as a thermal profile mimicking the material extrusion process (MEX). The results of the analysis reveal changes in the crystalline morphology, as indicated by a shift in intensity between melting peaks crystalized at different isothermal temperatures and cooling rates. Furthermore, the behavior of the deconvoluted melting peaks differs depending on the substrate temperature during the MEX process simulation. The presence of double or multiple melting peaks suggests the presence of different crystalline populations during the manufacturing process. Understanding the formation and changes in these melting peaks can help inform the development of better printing strategies and improve the mechanical performance of printed parts.
Virtual agents that flatter you: Moderating effects of self‐esteem and customization target in e‐customization services
Authors: Li Xueni (Shirley) , Si Wei , Chan Kimmy Wa 
Published: November 2023

AbstractAs e‐customization services have grown in popularity, companies widely use virtual agents in such services to improve consumers' online shopping experience. However, extant research has not thoroughly clarified the best way to leverage the use of virtual agents and involve consumers in the e‐customization process. Drawing on self‐enhancement and self‐verification theories, this research investigates the effects of an instrumental social influence tactic employed by virtual agents—specifically, flattering feedback—and the pivotal roles of consumers' self‐esteem and customization target when evaluating and using e‐customization services. Through four experiments that simulate e‐customization experiences using different products, we find that the effect of virtual agents' flattering feedback on customization outcomes (i.e., word‐of‐mouth, product interest, and actual purchase) is contingent on consumers' self‐esteem. Among consumers with high self‐esteem, flattering (vs. generic) feedback from virtual agents in the e‐customization process elicits more positive customization outcomes. In contrast, the opposite is true among those with low self‐esteem. Moreover, consumers' process involvement mediates the interaction effects, and the interaction effects are attenuated when consumers customizing the product for others (vs. oneself). Our work contributes to online customization research by unveiling the mechanism and boundary conditions of the potentially double‐edged effect of virtual agents' flattery.
Progress in cancer neuroscience
Authors: Lan Yu‐Long , Zou Shuang , Wang Wen , Chen Qi , Zhu Yongjian 
Published: November 2023

AbstractCancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and metastases, indicating how cancers invade complex neuronal networks. This review systematically discussed the interactions between neurons and cancers and elucidates new therapeutic avenues. We have overviewed the current understanding of direct or indirect communications of neuronal cells with cancer and the mechanisms associated with cancer invasion. Besides, tumor‐associated neuronal dysfunction and the influence of cancer therapies on the CNS are highlighted. Furthermore, interactions between peripheral nervous system and various cancers have also been discussed separately. Intriguingly and importantly, it cannot be ignored that exosomes could mediate the “wireless communications” between nervous system and cancer. Finally, promising future strategies targeting neuronal–brain tumor interactions were reviewed. A great deal of work remains to be done to elucidate the neuroscience of cancer, and future more research should be directed toward clarifying the precise mechanisms of cancer neuroscience, which hold enormous promise to improve outcomes for a wide range of malignancies.
Pentanucleotide Repeat Insertions in RAI1 Cause Benign Adult Familial Myoclonic Epilepsy Type 8
Authors: Yeetong Patra , Dembélé Mohamed E. , Pongpanich Monnat , Cissé Lassana , Srichomthong Chalurmpon , Maiga Alassane B. , Dembélé Kékouta , Assawapitaksakul Adjima , Bamba Salia , Yalcouyé Abdoulaye , Diarra Salimata , Mefoung Samuel Ephrata , Rakwongkhachon Supphakorn , Traoré Oumou , Tongkobpetch Siraprapa , Fischbeck Kenneth H. , Gahl William A. , Guinto Cheick O. , Shotelersuk Vorasuk , Landouré Guida 
Published: November 2023

AbstractBackgroundBenign adult familial myoclonic epilepsy (BAFME) is an autosomal dominant disorder characterized by cortical tremors and seizures. Six types of BAFME, all caused by pentanucleotide repeat expansions in different genes, have been reported. However, several other BAFME cases remain with no molecular diagnosis.ObjectivesWe aim to characterize clinical features and identify the mutation causing BAFME in a large Malian family with 10 affected members.MethodsLong‐read whole genome sequencing, repeat‐primed polymerase chain reaction and RNA studies were performed.ResultsWe identified TTTTA repeat expansions and TTTCA repeat insertions in intron 4 of the RAI1 gene that co‐segregated with disease status in this family. TTTCA repeats were absent in 200 Malian controls. In the affected individuals, we found a read with only nine TTTCA repeat units and somatic instability. The RAI1 repeat expansions cause the only BAFME type in which the disease‐causing repeats are in a gene associated with a monogenic disorder in the haploinsufficiency state (ie, Smith‐Magenis syndrome [SMS]). Nevertheless, none of the Malian patients exhibited symptoms related to SMS. Moreover, leukocyte RNA levels of RAI1 in six Malian BAFME patients were no different from controls.ConclusionsThese findings establish a new type of BAFME, BAFME8, in an African family and suggest that haploinsufficiency is unlikely to be the main pathomechanism of BAFME. © 2023 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Docosahexaenoic Acid‐Acylated Astaxanthin Monoester Ameliorates Amyloid‐β Pathology and Neuronal Damage by Restoring Autophagy in Alzheimer's Disease Models
Authors: Wang Xiaoxu , Song Yu , Cong Peixu , Wang Zhigao , Liu Yanjun , Xu Jie , Xue Changhu 
Published: November 2023

ScopeAstaxanthin (AST) is ubiquitous in aquatic foods and microorganisms. The study previously finds that docosahexaenoic acid‐acylated AST monoester (AST‐DHA) improves cognitive function in Alzheimer's disease (AD), although the underlying mechanism remains unclear. Moreover, autophagy is reportedly involved in amyloid‐β (Aβ) clearance and AD pathogenesis. Therefore, this study aims to evaluate the preventive effect of AST‐DHA and elucidates the mechanism of autophagy modulation in Aβ pathology.Methods and resultsIn the cellular AD model, AST‐DHA significantly reduces toxic Aβ1‐42 levels and alleviated the accumulation of autophagic markers (LC3II/I and p62) in Aβ25‐35‐induced SH‐SY5Y cells. Notably, AST‐DHA restores the autophagic flux in SH‐SY5YmRFP‐GFP‐LC3 cells. In APP/PS1 mice, a 3‐month dietary supplementation of AST‐DHA exceeded free‐astaxanthin (F‐AST) capacity to increase hippocampal and cortical autophagy. Mechanistically, AST‐DHA restores autophagy by activating the ULK1 signaling pathway and restoring autophagy‐lysosome fusion. Moreover, AST‐DHA relieves ROS production and mitochondrial stress affecting autophagy in AD. As a favorable outcome of restored autophagy, AST‐DHA mitigates cerebral Aβ and p‐Tau deposition, ultimately improving neuronal function.ConclusionThe findings demonstrate that AST‐DHA can rectify autophagic impairment in AD, and confer neuroprotection in Aβ‐related pathology, which supports the future application of AST as an autophagic inducer for maintaining brain health.
Quantification of fabric evolution in granular material under cyclic loading
Authors: Mo Weibin , Wang Rui , Zhang Jian‐Min , Dafalias Yannis F. 
Published: November 2023

AbstractFabric influences the macro scale mechanical properties and behavior of granular materials as a continuum and can be represented by an appropriately defined evolving fabric tensor entering the constitutive equations. In this study, the evolution of fabric tensors under cyclic loading is investigated and quantified by a series of cyclic loading DEM tests. Simulations of the DEM data are made by two different continuum evolution rate equations for the contact normal‐based fabric tensor, both within the Anisotropic Critical State Theory (ACST) framework: the first, is a Basic Fabric Evolution (BFE) equation and the second, is a novel Combined Fabric Evolution (CFE) equation, where a quantity related to particle‐based fabric tensor is considered. The comparison with DEM results highlights the capability of the CFE equation in simulating fabric evolution under cyclic loading for different anisotropy, density, and loading conditions. In addition, such simulations are significantly more accurate in comparison with those obtained by the BFE equation. The reason for the superiority of CFE over the BFE is the incorporation of the influence of the particle orientation fabric on contact normal fabric evolution. Analytical evaluation of CFE further identifies a total of seven periodic stable contact normal fabric evolution patterns that exist under cyclic loading, governed by initial void ratio, intensity of anisotropy, and stress amplitude. The limitation of current fabric evolution equations in being able to only reflect the proportional coaxial part of the fabric tensor with respect to the loading direction is discussed.