bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of CART Time-Based Feature Expansion in Dengue Classification Index Rate
Authors: Suhendar Annisya Hayati , Rohmawati Aniq Atiqi , Prasetyowati Sri Suryani 
Published: January 2024

This study proposes utilizing the machine learning technique CART to classify the spread of dengue hemorrhagic fever (DHF). To expand the features used, the CART classification model was developed based on data collected over the previous 2 to 4 years. The data sources included the Bandung City Health Office for the cases of DHF, the Bandung Meteorology, Climatology and Geophysics Agency for the climate data, the Bandung City Central Statistics Agency for population and educational history data. The top-performing CART classification model over the past 2, 3, and 4 years achieved accuracies of 93%, 93%, and 90%, respectively. The models that exhibited the highest accuracy values and optimal number of feature extensions were chosen as the best ones. CART is among several machine learning techniques that can effectively measure the most impactful features during the classification process. The meteorological parameters were found to be irrelevant in the classification process. This study reveals that the population size, male population proportion, and educational attainment levels are the most impactful features in the classification of DHF spread in Bandung City. The research provides valuable insights into the classification of DHF spread in Bandung City through feature expansion.
Challenges in the Diagnosis and Management of Intracranial Abscess in Developing Countries: A Retrospective Study from a Tertiary Hospital in Indonesia
Authors: Imron Akhmad , Turbawaty Dewi Kartika , Sumargo Sheila , Ardisasmita Mulya Nurmansyah 
Published: January 2024

Despite progressive development of antibiotics and surgical approaches, outcomes in patients with intracranial abscess remained far from ideal. This paper aimed to describe challenges in the diagnosis and treatment of intracranial abscess in developing countries based on study from a tertiary hospital in Indonesia. A retrospective study was performed and included patients who were suspected of intracranial abscess at a tertiary referral hospital in Indonesia between January 1, 2012 and January 1, 2020. Clinical, radiological and laboratory characteristics were analyzed. Two-hundred-and-seventy-seven patients were initially enrolled. Age (p = 0.001), GCS at admission (p = 0.009), comorbidity with hypoalbuminemia (p = 0.003) and hydrocephalus (p = 0.009) are significantly associated with patients’ GCS when discharged. Results from culture and resistance tests could only be retrieved from 66 patients, with 33 (50%) obtained negative results, while the other 33 (50%) results were positive, consisted of 20 (60.6%) were of gram-negative bacteria and 13 (39.4%) were of gram-positive bacteria. Treatments that are directed to hypoalbuminemia and hydrocephalus should also be prioritized when any of these comorbidities exist.
Elderly Female with Pulmonary Oedema Manifestation of Dengue Hemorrhagic Fever : a Case Report
Authors: Gunawan Mikhael Fabian , Sjam Mohammad Bhukkar Adil , Miranda Adriana Viola 
Published: January 2024

Dengue Hemorrhagic Fever (DHF) is an arthropod borne viral disease. The main vector of the disease are the Aedes mosquitoes. Indonesia as one of the tropical nations in South Asia falls into one of the countries in which DHF is an endemic. The notable clinical symptoms are fever usually 400c with a biphasic pattern in 6% of DHF cases, body ache, muscles, retroorbital and joints, nausea, and vomiting. Fluid accumulation, due to plasma leakage, may occur in the abdominal cavities, pleural space, and even the lungs. The rise of non-communicable diseases like diabetes mellitus has impacted the clinical progression of DHF by increasing the risk of developing into dengue shock syndrome and atypical clinical manifestation of dengue plasma leakage and bleeding disorder. This case report discusses one of these atypical clinical manifestations of DHF. The case is an elderly female presenting in the emergency room with a DHF, Diabetes mellitus type 2, cardiomegaly, and during inpatient care developed a pulmonary Oedema. The patient experienced prolonged fever and on the 7th day of care develops a pulmonary oedema, the patient is then moved to the intensive care unit, and with proper treatment and monitoring was able to recover from the disease
English Studentsâ€™ Attitudes toward the Implementation of Multiple Distanced-Learning Platforms during Covid-19 Outbreak
Authors: Fujiono Fujiono 
Published: January 2024

This preliminary case study was to describe how the enactment of multiple distanced learning platform has impacts of studentsâ€™ attitudes during the covid-19 outbreak. . The data were garnered from the zoom and whatApps mediated English learning in the university in Madura. The results indicate not only psychological but also hardskills of the English arose. The students felt their motivation to have online learning develop as well as their attitude toward their English learning.Â As immerging data are still limited in terms of coverage and still in on going interpretation and analysis, the students English skills become significant to investigate in the future.Â Studi kasus pendahuluan ini untuk mendeskripsikan bagaimana pemberlakuan platform pembelajaran jarak jauh ganda memiliki dampak terhadap sikap siswa selama wabah covid-19. . Data dikumpulkan dari zoom dan whatApps yang dimediasi pembelajaran bahasa Inggris di universitas di Madura. Hasil menunjukkan tidak hanya psikologis tetapi juga hardskills bahasa Inggris muncul. Para siswa merasakan motivasi mereka untuk mengembangkan pembelajaran online serta sikap mereka terhadap pembelajaran bahasa Inggris mereka. Karena data yang muncul masih terbatas dalam hal cakupan dan masih dalam interpretasi dan analisis yang sedang berlangsung, kemampuan bahasa Inggris siswa menjadi penting untuk diselidiki di masa depan.
Studentsâ€™ Perception of Gamified Online Quizzes and Its Impacts on Their Classroom Engagement
Authors: Zainiah Zahro , Putri Nanin Verina Widya 
Published: January 2024

Gamification has been very popular in educational field. As a consequence, there were many researchers interested to conduct a study on it. In order to give contribution for enriching the resources for such study, this research investigated studentsâ€™ view toward the use of gamified online quizzes given by the teacher outside the classroom, as well as to examine the impact on studentsâ€™ engagement in the classroom. The method used was qualitative, with questionnaires and interview as the instruments. The participants were 69 twelfth graders students of three classes who filled the questionnaires, as 9 students among them were interviewed as the representatives. Results showed that students perceived experience in using gamified online quizzes was positive. They recognized such quizzes as interactive and useful for their learning. Moreover, they were found to be engaged in using the gamified online quizzes. They showed their engagement in behavior, emotion, cognitive, and agenticÂ Gamifikasi sudah menjadi hal yang sangat popular dalam bidang Pendidikan. Sebagai konsekuensinya, banyak peneliti yang tertarik mengadakan kajian tentang hal tersebut. Untuk berkontribusi dalam memperkaya sumber data untuk kajian serupa, penelitian ini ditujukan untuk menyelidiki pandangan siswa dalam penggunaan kuis online berbentuk permainan yang diberikan oleh guru di luar kelas, sekaligus meneliti dampaknya pada keterikatan siswa di dalam kelas. Metode yang digunakan adalah kualitatif, dengan kuisioner and wawancara sebagai alat penelitian. Peserta penelitian terdiri dari 69 siswa kelas 12 sebanyak 3 kelas yang mengisi kuisioner, dengan 9 siswa yang diwawancarai sebagai perwakilan. Hasil menunjukkan bahwa siswa merasakan pengalaman yang positif saat menggunakan kuis online berbentuk permainan. Mereka menganggap kuis tersebut menarik dan berguna untuk kelangsungan proses belajar mereka. Selain itu, siswa juga terikat penuh dalam menggunakan kuis tersebut. Mereka menunjukkan keterikatan secara perilaku, emosional, kognitif, dan agentik
The Infusion of Moral Values in A Commercial Publisher English Textbook
Authors: Rahmania Tasya , Pradita Intan 
Published: January 2024

This research aims to examine the infusion of moral value in English textbooks for middle school in Indonesia. The data were collected through transferring and normalizing the written data from a commercial English textbook entitled: English on Sky 2 forÂ SMP/MTs kelas VII to the Antconc software. The data were analyzed by using corpus based analysis. In order to employ this type of analysis, we used the AntConc corpus analysis software and using vocabularies adopted by previous researchers. The findings of this research showed that the moral values that are represented in this textbook there are two moral values, which are values toward others and values toward self. For values toward others, there are sub values such as conveying kindness, as example is being helpful, and keeping promise; showing respect, such as asking permission and apologizing; showing affection, such as giving compliments, showing close relation with God. Moreover, for moral values towards self such as conveying how to appreciate, accept, yourself.Â
Changes in DNA methylation associated with a specific mode of delivery: a pilot study
Authors: Krumpolec Patrik , Kodada Dominik , Hadžega Dominik , Petrovič Oliver , Babišová Klaudia , Dosedla Erik , Turcsányiová Zuzana , Minárik Gabriel 
Published: January 2024

BackgroundThe mode of delivery represents an epigenetic factor with potential to affect further development of the individual by multiple mechanisms. DNA methylation may be one of them, representing a major epigenetic mechanism involving direct chemical modification of the individual’s DNA. This pilot study aims to examine whether a specific mode of delivery induces changes of DNA methylation by comparing the umbilical cord blood and peripheral blood of the newborns.MethodsBlood samples from infants born by vaginal delivery and caesarean section were analysed to prepare the Methylseq library according to NEBNext enzymatic Methyl-seq Methylation Library Preparation Kit with further generation of target-enriched DNA libraries using the Twist Human Methylome Panel. DNA methylation status was determined using Illumina next-generation sequencing (NGS).ResultsWe identified 168 differentially methylated regions in umbilical cord blood samples and 157 regions in peripheral blood samples. These were associated with 59 common biological, metabolic and signalling pathways for umbilical cord and peripheral blood samples.ConclusionCaesarean section is likely to represent an important epigenetic factor with the potential to induce changes in the genome that could play an important role in development of a broad spectrum of disorders. Our results could contribute to the elucidation of how epigenetic factors, such as a specific mode of delivery, could have adverse impact on health of an individual later in their life.
Characteristics and duties of clinical research nurses: a scoping review
Authors: Xing Ying , Wang Xinxin , Zhang Chengrui , Yuan Weian , Chen Xinlin , Luan Wei 
Published: January 2024

IntroductionThe characteristics and duties of clinical research nurses (CRNs) are constantly developing and changing with the progress of medical technology and increasing needs in patient care. With the continuous deepening and standardization of clinical trials, the importance and status of CRNs during the whole process of clinical trials are also increasingly valued.MethodsA scoping review of studies related to the characteristics and duties of CRNs was conducted to clarify relevant roles and concepts. An electronic search was conducted on three English databases (PubMed, Web of Science, Embase) and two Chinese databases (CNKI and Wanfang database) in December 2023. Two authors independently screened the literature, extracted information from the included literature, and summarized and reported the findings.ResultsA total of 26 articles published between 1991 and 2023 were analyzed, and four characteristics of CRNs were identified as participants and managers of clinical trials, caregivers and protectors of subjects, coordinators of research teams, and educators. Basic knowledge, skills and literacy, communication and coordination ability, and advanced research ability are the competencies required for CRNs.ConclusionFurther studies should focus on the importance of various characteristics of CRNs, so as to improve the quality of clinical trials and promote clinical evidence-based practice.
Clinical predictive value of the initial neutrophils to lymphocytes and platelets ratio for prognosis of sepsis patients in the intensive care unit: a retrospective study
Authors: Zhang Jinhui , Zhao Qun , Hu Zhenkui 
Published: January 2024

BackgroundNeutrophils to lymphocytes and platelets (N/LP) ratio has been confirmed as an indirect marker of inflammation. In this study, we aimed to further evaluate the prognostic significance of the N/LP ratio in sepsis patients admitted to the ICU.MethodsSepsis patients from the Affiliated Hospital of Jiangsu University were retrospectively enrolled from January 2015 and July 2023. The primary outcomes were 30/60 days mortality. The secondary outcomes included the incidence of AKI, vasoactive drug, CRRT, invasive ventilation, length of ICU stay, length of hospital stay and ICU mortality.ResultsA total of 1,066 sepsis patients were enrolled with a median age of 75.0 (66.0, 85.0) years, and 62.5% of them being male. The 30 days and 60 days mortality rates were found to be 28.7 and 34.0%, respectively, while the incidence of AKI was 45.2%. Based on their N/LP ratios, we classified the sepsis patients into three groups: low, middle, and high, consisting of 266, 534, and 266 patients, respectively. According the Cox proportional hazard model, the middle and high N/LP groups were associated with a 1.990/3.106-fold increase in 30 days mortality risk and a 2.066/3.046-fold increase in 60 days mortality risk compared with the low N/LP group. Besides, multivariate logistic regression model suggested that the risk of AKI occurrence increased 2.460 fold in the high group compared to the low group. However, through subgroup analyses, we observed substantial variations in the association between N/LP ratios and 30/60 days mortality rates as well as the incidence of AKI among different populations. Notably, the N/LP ratio measured at ICU admission exhibited a higher AUC for predicting 30/60 days mortality (0.684/0.687). Additionally, we observed a good predictive power for the occurrence of AKI (AUC: 0.645) using the N/LP ratio measured at sepsis prognosis. Regarding the other secondary outcomes, the N/LP ratio was associated with disease severity in sepsis patients, including the need for vasoactive drugs, length of ICU stay, and ICU mortality.ConclusionThe N/LP ratio at ICU admission was found to have a significant independent association with 30/60 days mortality and the incidence of AKI in sepsis patients.
Development and application of an amplified luminescent proximity homogeneous assay-linked immunosorbent assay for the accurate quantification of kidney injury molecule-1
Authors: Fu Yulin , Sun Danqin , Qin Yuan , Zheng Tianyu , Zhou Zixuan , Zhou Xiumei , Zhao Xueqin , Xu Yan , Huang Biao 
Published: January 2024

Background: Kidney injury molecule-1 (Kim-1), a specific marker of kidney injury, is usually not expressed in normal kidneys or at very low levels but is highly expressed in injured renal tubular epithelial cells until the damaged cells recover completely. Therefore, we aimed to develop an efficient and highly sensitive assay to accurately quantify Kim-1 levels in human serum and urine.Methods: In this study, a novel immunoassay was developed and named amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA). Anti-Kim-1 antibodies can be directly coupled to carboxyl-modified donor and acceptor beads for the rapid detection of Kim-1 by double-antibody sandwich method. Serum and urine samples for Kim-1 measurements were obtained from 129 patients with nephropathy and 17 healthy individuals.Results: The linear range of Kim-1 detected by AlphaLISA was 3.83–5000 pg/mL, the coefficients of variation of intra-assay and inter-assay batches were 3.36%–4.71% and 5.61%–11.84%, respectively, and the recovery rate was 92.31%–99.58%. No cross reactions with neutrophil gelatinase-associated lipocalin, liver-type fatty acid binding protein, and matrix metalloproteinase-3 were observed. A good correlation (R2 = 0.9086) was found between the findings of Kim-1-TRFIA and Kim-AlphaLISA for the same set of samples. In clinical trials, both serum and urine Kim-1 levels were significantly higher in patients with nephropathy than in healthy individuals, especially in patients with acute kidney injury. Furthermore, serum Kim-1 was superior to urinary Kim-1 in distinguishing between patients with nephropathy and healthy individuals.Conclusion: The developed Kim-1-AlphaLISA is highly efficient, precise, and sensitive, and it is suitable for the rapid detection of patients with acute kidney injury.
Investigation of protein-protein interactions and hotspot region on the NSP7-NSP8 binding site in NSP12 of SARS-CoV-2
Authors: Lima Neto José Xavier , Bezerra Katyanna Sales , Barbosa Emmanuel Duarte , Araujo Roniel Lima , Galvão Douglas Soares , Lyra Marcelo Leite , Oliveira Jonas Ivan Nobre , Akash Shopnil , Jardan Yousef A. Bin , Nafidi Hiba-Allah , Bourhia Mohammed , Fulco Umberto Laino 
Published: January 2024

Background: The RNA-dependent RNA polymerase (RdRp) complex, essential in viral transcription and replication, is a key target for antiviral therapeutics. The core unit of RdRp comprises the nonstructural protein NSP12, with NSP7 and two copies of NSP8 (NSP81 and NSP82) binding to NSP12 to enhance its affinity for viral RNA and polymerase activity. Notably, the interfaces between these subunits are highly conserved, simplifying the design of molecules that can disrupt their interaction.Methods: We conducted a detailed quantum biochemical analysis to characterize the interactions within the NSP12-NSP7, NSP12-NSP81, and NSP12-NSP82 dimers. Our objective was to ascertain the contribution of individual amino acids to these protein-protein interactions, pinpointing hotspot regions crucial for complex stability.Results: The analysis revealed that the NSP12-NSP81 complex possessed the highest total interaction energy (TIE), with 14 pairs of residues demonstrating significant energetic contributions. In contrast, the NSP12-NSP7 complex exhibited substantial interactions in 8 residue pairs, while the NSP12-NSP82 complex had only one pair showing notable interaction. The study highlighted the importance of hydrogen bonds and π-alkyl interactions in maintaining these complexes. Intriguingly, introducing the RNA sequence with Remdesivir into the complex resulted in negligible alterations in both interaction energy and geometric configuration.Conclusion: Our comprehensive analysis of the RdRp complex at the protein-protein interface provides invaluable insights into interaction dynamics and energetics. These findings can guide the design of small molecules or peptide/peptidomimetic ligands to disrupt these critical interactions, offering a strategic pathway for developing effective antiviral drugs.
Intraoperative assessment of anastomotic blood supply using indocyanine green fluorescence imaging following esophagojejunostomy or esophagogastrostomy for gastric cancer
Authors: Wang Peng , Tian Yantao , Du Yongxing , Zhong Yuxin 
Published: January 2024

ObjectiveThis retrospective study aimed to evaluate the feasibility and safety of intraoperative assessment of anastomotic blood supply in patients undergoing esophagojejunostomy or esophagogastrostomy for gastric cancer using Indocyanine Green Fluorescence Imaging (IGFI).Materials and methodsFrom January 2019 to October 2021, we conducted a retrospective analysis of patients who had undergone laparoscopic gastrectomy for the treatment of gastric cancer. The patients were consecutively enrolled and categorized into two study groups: the Indocyanine Green Fluorescence Imaging (IGFI) group consisting of 86 patients, and the control group comprising 92 patients. In the IGFI group, intravenous administration of Indocyanine Green (ICG) was performed, and we utilized a fluorescence camera system to assess anastomotic blood supply both before and after the anastomosis.ResultsThe demographic characteristics of patients in both groups were found to be comparable. In the IGFI group, the mean time to observe perfusion fluorescence was 26.3 ± 12.0 seconds post-ICG injection, and six patients needed to select a more proximal resection point due to insufficient fluorescence at their initial site of choice. Notably, the IGFI group exhibited a lower incidence of postoperative anastomotic leakage, with no significant disparities observed in terms of pathological outcomes, postoperative recovery, or other postoperative complication rates when compared to the control group (p &gt; 0.05).ConclusionThis study underscores the potential of IGFI as a dependable and pragmatic tool for the assessment of anastomotic blood supply following esophagojejunostomy or esophagogastrostomy for gastric cancer. The use of IGFI may potentially reduce the occurrence of postoperative anastomotic leakage.
Intravenous ondansetron for the prevention of supine hypotensive syndrome during spinal anesthesia for cesarean section: a randomized controlled trial
Authors: Zhang Yuan , Xiao Fen , Zhang Wangping 
Published: January 2024

Background: Supine hypotensive syndrome is a common complication in late pregnancy. This study aims to explore the effects of ondansetron on the prevention of supine hypotensive syndrome during spinal anesthesia for cesarean section.Methods: A total of 80 women undergoing elective cesarean delivery were randomly assigned to two groups (the ondansetron group and the control group), with 40 cases in each group. The ondansetron group received 0.075 mg/kg of ondansetron intravenously 5 min before the induction of spinal anesthesia; the control group was given the same volume of saline solution. The blood pressure and heart rate were measured. Umbilical artery pH was analyzed, and the incidence of nausea and vomiting and vasoconstrictor drug usage were noted.Results: The incidence of supine hypotensive syndrome, nausea and vomiting, and vasoconstrictor drug use were significantly lower in the ondansetron group than the control group (2.5% vs. 20%, p = 0.029; 2.5% vs. 22.5%, p = 0.007; and 5% vs. 22.5%, p = 0.012, respectively). Umbilical artery pH was higher in the ondansetron group than the control group, and statistical significance was observed (7.31 ± 0.03 vs. 7.28 ± 0.04, p = 0.002). The maternal hemodynamic parameters and the neonatal Apgar score were similar between the two groups.Conclusion: Ondansetron can effectively prevent supine hypotensive syndrome, reduce the incidence of nausea, vomiting, and vasoconstrictor drug use, and improve neonatal umbilical arterial pH during spinal anesthesia for cesarean section.Clinical Trial Registration:https://www.chictr.org.cn/, identifier ChiCTR180018756.