bluuebunny/crossref_metadata_2025_split huggingface dataset:
Web Service Modeling Ontology
Authors: Roman Dumitru , Keller Uwe , Lausen Holger , de Bruijn Jos , Lara Rubén , Stollberg Michael , Polleres Axel , Feier Cristina , Bussler Cristoph , Fensel Dieter 
Published: January 2025

The potential to achieve dynamic, scalable and cost-effective marketplaces and eCommerce solutions has driven recent research efforts towards so-called Semantic Web Services that are enriching Web services with machine-processable semantics. To this end, the Web Service Modeling Ontology (WSMO) provides the conceptual underpinning and a formal language for semantically describing all relevant aspects of Web services in order to facilitate the automatization of discovering, combining and invoking electronic services over the Web. In this paper we describe the overall structure of WSMO by its four main elements: ontologies, which provide the terminology used by other WSMO elements, Web services, which provide access to services that, in turn, provide some value in some domain, goals that represent user desires, and mediators, which deal with interoperability problems between different WSMO elements. Along with introducing the main elements of WSMO, we provide a logical language for defining formal statements in WSMO together with some motivating examples from practical use cases which shall demonstrate the benefits of Semantic Web Services.
Outer Solar System Spacecraft Without Drag-Free Control to Probe the µHz Gravitational Wave Frontier
Authors: McQuinn Matthew , McGrath Casey 
Published: January 2025

The microhertz frequency band of gravitational waves probes the merger of supermassive black holes as well as many other gravitational wave phenomena. However, space-interferometry methods that use test masses would require substantial development of test-mass isolation systems to detect anticipated astrophysical events. We propose an approach that avoids on-board inertial test masses by situating spacecraft in the low-acceleration environment of the outer Solar System. We show that for Earth-spacecraft and inter-spacecraft distances of \(\gtrsim 10\)AU, the accelerations on the spacecraft would be sufficiently small to potentially achieve gravitational wave sensitivities determined by stochastic gravitational wave backgrounds. We further argue, for arm lengths of \(10 - 30\)AU and \(\sim 10\)Watt transmissions, that stable phase locks could be achieved with 20 cm mirrors or \(5\) m radio dishes, although for the laser case this would require lower laser frequency noise relative to the LISA lasers. We discuss designs that send both laser beams and radio waves between the spacecraft, finding that despite the \(\sim 10^{4} \times\) longer wavelengths, even a design with radio transmissions could reach stochastic background-limited sensitivities at \(\lesssim {0.3 \times 10^{- 4}}\)Hz. Operating in the radio significantly reduces many spacecraft design tolerances. Our baseline concept requires two arms to do interferometry. However, if one spacecraft carries a clock with Allan deviations at \(10^{4}\) seconds of \(10^{- 17}\), a comparable sensitivity could be achieved with a single arm. Finally, we discuss the feasibility of achieving similar gravitational wave sensitivities in a ‘Doppler tracking’ configuration where the single arm is anchored to Earth.
LAS AVES DE GRANJA REQUIEREN VACUNARSE PARA MANTENER LA PRODUCCIÓN DE ALIMENTOS CON ALTO VALOR NUTRICIONAL A BAJO COSTO
Authors: Matias Vera Sergio Alberto , Sánchez Alonso María Patricia , Negrete Abascal Erasmo , Vázquez Cruz Candelario 
Published: January 2025

El sector avícola es uno de los más importantes en el mundo y en la sociedad mexicana, gracias a la producción de alimentos de primera necesidad, un ejemplo de esto es que México ocupa los primeros lugares en la exportación de huevo y presenta un consumo per cápita de 22 kilos, posicionándose como el mayor consumidor a nivel mundial. Sin embargo, la industria avícola se ve afectada por infecciones como la coriza infecciosa causada por Avibacterium paragallinarum o la gallibacteriosis cuyo agente causal es Gallibacterium anatis. Estas afectan principalmente a gallinas de postura y pollos de engorde, causando una disminución del 10 al 40% en la producción de huevo, impactando directamente en la salud pública y generando pérdidas económicas relevantes. Lo anterior destaca la importancia en la búsqueda de nuevas alternativas para tener mayor control y prevención de infecciones, donde A. paragallinarum y G. anatis poseen características potenciales para ello.
CUIDANDO LA SALUD DEL CUIDADOR; EL CONTEXTO EN EL TRASPLANTE DE CÉLULAS PROGENITORAS HEMATOPOYÉTICAS
Authors: Porras Juárez Angélica , González Vergara Enrique 
Published: January 2025

Actualmente, en materia de cuidado existen muchos desafíos, incluyendo que los familiares y amigos cuidadores asuman responsabilidades esenciales de atención médica, frecuentemente sin capacitación ni apoyo inadecuados, exponiéndose a riesgos que perjudican su salud por desempeñar una actividad agobiante y estresante. El bienestar del cuidador es pieza fundamental del equipo multidisciplinario que participa en el complejo proceso del trasplante de progenitores hematopoyéticos. En este artículo se exponen algunos datos sobre la pequeña, pero creciente población de cuidadores, su función, sus principales necesidades de salud, y finalmente algunas estrategias de intervención que se han investigado y reportado como exitosas en términos de salud.
Group Counseling for Fostering Resident at UPTD Social Welfare Centre (UPTD-PSRAMPK) Ogan Ilir
Authors: Appulembang Yeni Anna , Zefany Tarian Angeline , Prapto Nugroho Indra 
Published: January 2025

Social Rehabilitation is spread across several cities in Indonesia and one of them is in South Sumatra which is located in Ogan Ilir. Children included in the UPTD Children's Rehabilitation Social Home Need Special Protection (UPTD – RAMPK) from various problems. Based on the results of observations, it show that the inmates also experience psychological issues, one of which is self-esteem. The subjects showed that they had negative feelings within themselves. They consider that they cannot do something even though they have been given various activities to improve their hard skills. The problem of low self-esteem can be overcome through a group counseling approach. Group counseling can also be a therapeutic medium for individuals to improve self-understanding and behavior change. The counseling session consists of 5 stages, namely: (a) the initial stage; (b) the transition stage; (c) the working stage; (d) the termination stage; and (e) follow-up. Subjects are also given a pretest and posttest. Based on the results of statistical data analysis using the paired sample t-test, it was found that there was a difference in scores before and after the provision of group counseling. This is shown by the mean value before group counseling of 25.10 and the mean value after group counseling of 26.60. The standard deviation value before group counseling was 1.28 and the standard deviation after group counseling was 1.95. In addition, the results of the data analysis conducted a test of the difference in a p-value of 0.048 < 0.05. This shows that there is a significant difference before and after the provision of group counseling to Assisted Residents at the UPTD Social Rehabilitation Home for Children in Need of Special Protection (RAMPK).
Assessment of the Structure and Properties of Manually Laser-Beam-Welded Joints of Steel DOCOL 1200M
Authors: Górka Jacek , Jankowska Dagmara , Stano Sebastian 
Published: January 2025

The research work aimed to determine the effect of manual laser beam welding process parameters on the properties of butt joints made of 1.8 mm thick steel DOCOL 1200M. The test joints were subjected to non-destructive (visual and penetrant) tests as well as destructive tests including static tensile tests, bend tests, hardness measurements as well as macro and microscopic metallographic tests. The optimisation of welding process parameters enabled the obtainment of joints satisfying both visual and strength-related quality requirements. The tests revealed that the use of the so-called continuous-wave laser beam helped minimise the number of welding imperfections. As a result of the laser beam welding process, the hardness in the heat affected zone (HAZ) decreased to approximately 260 HV, if compared to that of 360 HV in the base material and 370 HV in the weld.
A JURIDICAL ANALYSIS OF CORAL REEF CONSERVATION STRATEGIES IN DERAWAN ISLANDS
Authors: Tarigan Muhammad Insan , Tjondro Tirtamulia  
Published: January 2025

Berau Regency are an area of highly diverse and endangered coral reefs. Coral reefs play a very important role in the life of the marine environment. Therefore, the purpose of this research is to explore the legal basis that can protect the sustainability of coral reefs both at the international, national and local levels as well as the legal basis that guarantees the empowerment of local communities in the protection of coral reefs. The different approaches and international agreements that have been positively applied to ensure the protection of the marine environment and have bound the different countries. This article is written with normative legal research that prioritizes statutory approach and conceptual approach. In the end, it is found that Indonesia has bound itself to several international agreements that can be used as a legal umbrella in regulating the protection of coral reefs through national law. Indonesian legal instruments are heavily influenced by international law and policy. In fact, the Berau Regency Government has issued a regional regulation to maintain the quality of coral reefs in the Derawan Islands as an effort to meet and achieve marine conservation goals set at the global level. The legislation framework in Derawan has ensured community participation in the protection of maritime habitats, including coral reefs. However, there is no legal instrument that specifically and comprehensively regulates the conservation work of coral reef at the national level.
Keywords: Coral Reefs; Legal Protection; SDGs.
Enhancing cardiac assessments: accurate and efficient prediction of quantitative fractional flow reserve
Authors: Eskandari Arshia , Malek Sara , Jabbari Alireza , Javari Kian , Rahmati Nima , Nikbakhtian Behrad , Mohebbi Bahram , Parhizgar Seyed Ehsan , Alimohammadi Mona 
Published: January 2025

BackgroundObstruction within the left anterior descending coronary artery (LAD) is prevalent, serving as a prominent and independent predictor of mortality. Invasive Fractional flow reserve (FFR) is the gold standard for Coronary Artery Disease risk assessment. Despite advances in computational and imaging techniques, no definitive methodology currently assures clinicians of reliable, non-invasive strategies for future planning.MethodThe present research encompassed a cohort of 150 participants who were admitted to the Rajaie Cardiovascular, Medical, and Research Center. The method includes a three-dimensional geometry reconstruction, computational fluid dynamics simulations, and methodology optimization for the computation time. Four patients are analyzed within this study to showcase the proposed methodology. The invasive FFR results reported by the clinic have validated the optimized model.ResultsThe computational FFR data derived from all methodologies are compared with those reported by the clinic for each case. The chosen methodology has yielded virtual FFR values that exhibit remarkable proximity to the clinically reported patient-specific FFR values, with the MSE of 6.186e-7 and R2 of 0.99 (p = 0.00434).ConclusionThis approach has shown reliable results for all 150 patients. The results are both computationally and clinically user-friendly, with the accumulative pre and post-processing time of 15 min on a desktop computer (Intel i7 processor, 16 GB RAM). The proposed methodology has the potential to significantly assist clinicians with diagnosis.
Development and validation of a prediction model of hospital mortality for patients with cardiac arrest survived 24 hours after cardiopulmonary resuscitation
Authors: Zhang Renwei , Liu Zhenxing , Liu Yumin , Peng Li 
Published: January 2025

ObjectiveResearch on predictive models for hospital mortality in patients who have survived 24 h following cardiopulmonary resuscitation (CPR) is limited. We aim to explore the factors associated with hospital mortality in these patients and develop a predictive model to aid clinical decision-making and enhance the survival rates of patients post-resuscitation.MethodsWe sourced the data from a retrospective study within the Dryad dataset, dividing patients who suffered cardiac arrest following CPR into a training set and a validation set at a 7:3 ratio. We identified variables linked to hospital mortality in the training set using Least Absolute Shrinkage and Selection Operator (LASSO) regression, as well as univariate and multivariate logistic analyses. Utilizing these variables, we developed a prognostic nomogram for predicting mortality post-CPR. Calibration curves, the area under receiver operating curves (ROC), decision curve analysis (DCA), and clinical impact curve were used to assess the discriminability, accuracy, and clinical utility of the nomogram.ResultsThe study population comprised 374 patients, with 262 allocated to the training group and 112 to the validation group. Of these, 213 patients were dead in the hospital. Multivariate logistic analysis revealed age (OR 1.05, 95% CI: 1.03–1.08), witnessed arrest (OR 0.28, 95% CI: 0.11–0.73), time to return of spontaneous circulation (ROSC) (OR 1.05, 95% CI: 1.02–1.08), non-shockable rhythm (OR 3.41, 95% CI: 1.61–7.18), alkaline phosphatase (OR 1.01, 95% CI: 1–1.01), and sequential organ failure assessment (SOFA) (OR 1.27, 95% CI: 1.15–1.4) were independent risk factors for hospital mortality for patients who survived 24 h after CPR. ROC of the nomogram showed the AUC in the training and validation group was 0.827 and 0.817, respectively. Calibration curves, DCA, and clinical impact curve demonstrated the nomogram with good accuracy and clinical utility.ConclusionOur prediction model had accurate predictive value for hospital mortality in patients who survived 24 h after CPR, which will be beneficial for assisting in identifying high-risk patients and intervention. Further confirmation of the model's accuracy required external validation data.
Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus morhua)
Authors: Yadetie Fekadu , Zhang Xiaokang , Reboa Anna , Noally Gwenaëlle Samantha Chloe , Eilertsen Mariann , Fleming Mitchell Stewart , Helvik Jon Vidar , Jonassen Inge , Goksøyr Anders , Karlsen Odd André 
Published: January 2025

IntroductionThe pituitary and liver are among the main sites of action of estrogens in fish. Years of research has shown that xenoestrogens can interfere with functions of estrogens. There is however incomplete understanding of xenoestrogen targets genes, their molecular mechanisms and potential effects in some of the target organs, particularly the pituitary.MethodsWe performed a comprehensive analysis of pituitary and liver transcriptome 72 h after injection of ethynylestradiol (EE2: 10, 50 or 250 nmol/kg body weight/bw) and bisphenol A (BPA: 8, 40 or 200 μmol/kg bw) in juvenile female Atlantic cod (Gadus morhua).ResultsA broad range of reproductive and metabolic pathways were affected in both organs by BPA and EE2. In the pituitary, effects on the expression of many genes associated with reproduction-related hormonal pathways including the gonadotropin system, as well as genes in processes such as cell differentiation and metabolic homeostasis were observed. In the liver, in addition to upregulation of well-known estrogen marker genes, effects on metabolic pathways, in particular, a coordinated downregulation of genes in the triglyceride synthesis pathways were observed.DiscussionThe results suggest that estrogenic compounds affect a broad range of reproductive and metabolic processes in the pituitary. The alterations in the liver unravel the transcriptional changes underlying metabolic remodeling during estrogen induced vitellogenesis. This study provides new insights into mechanisms of endocrine and metabolic interactions that can be potential targets of environmental estrogens in fish. The study also identifies potential gene expression biomarkers for pituitary and liver effects of xenoestrogens.
The correlation between high-sensitivity cardiac troponin levels in diabetic patients’ serum and lower limb lesions: based on NHANES data
Authors: Li Lin , Jiao Linxi , Yang Danyang , Zhao Jingxia , Li Ping 
Published: January 2025

ObjectiveTo evaluate the association of hypersensitive cardiac troponin (hs-cTnT), a biomarker of myocardial injury, with diabetic lower extremity disease in American adults.MethodsWe conducted a cross-sectional study (unweighted N=1,196) of diabetic patients aged 40 years or older who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Logistic regression was used to assess the association of hs-cTnT with lower extremity disease, including peripheral neuropathy (as assessed by monofilament test), peripheral artery disease (as assessed by ankle-brachial index), history of foot ulcers, or amputation. All analyses are weighted.ResultsThe prevalence rate of diabetic lower extremity disease was 41.6%. Adjusted hs-cTnT was significantly associated with lower limb disease in adults with diabetes. There is interaction between chronic kidney disease and hs-cTnT, which strongly interferes with the correlation between hs-cTnT and lower extremity lesions in diabetic patients.ConclusionsOur study suggests the usefulness of hs-cTnT as a biomarker for lower extremity lesions in adults with diabetes and highlights the potential direct interaction of hs-cTnT with chronic kidney disease.
The role of SPINK5 mutation distribution in phenotypes of Netherton syndrome
Authors: Xu Min , Shi Yujie , Lin Li , Wang Liang , Zhu Xianzhong , Xiong Jinglin , Yin Jiawen , Qi Qing , Yang Wenlin 
Published: January 2025

ObjectiveNetherton syndrome (NS) is a rare hereditary dermatosis, and the correlation between genotype and phenotype in this disease warrants further investigation. This study aimed to explore the genotype-phenotype correlation in NS.MethodsWe collect cases from our clinic and relevant literature. After rigorous screening, we included 162 patients with NS-associated symptoms and SPINK5 mutations. We characterized the distribution and mutation types of allele variants. Logistic regression was employed to analyze the correlation between the location of these variants and phenotypes. Additionally, the association between the homozygous condition of variants and death during infancy was analyzed using the Chi-square test.ResultsAmong 162 patients, we identified 324 allele variants, comprising 75 different mutations. Of these, 73 patients carried heterozygous variants, while 89 patients had homozygous variants. We observed that patients with variants or homozygous variants located in the 5′ half of the gene were more likely to experience failure to thrive (P &lt; 0.05). Similarly, variants or homozygous variants located outside DomainR-5 were also associated with an increased risk of failure to thrive (P &lt; 0.05). Furthermore, variants in domain regions were significantly correlated with the presence of ichthyosis linearis circumflexa (P &lt; 0.01). Patients with homozygous fatal variants (c.153delT, c.1431-12G&gt;A, c.1111C&gt;T, c. 1887 + 1G&gt;A, and c. 995delT) had a higher likelihood of mortality during infancy (P &lt; 0.001).ConclusionOur study provides valuable insights into the genotype-phenotype correlation in Netherton syndrome, enhancing our understanding of the disease and potentially informing the development of future therapeutic approaches.
Immune microenvironment features underlying the superior efficacy of neoadjuvant immunochemotherapy over chemotherapy in local advanced gastric cancer
Authors: Zhang Ning , Li Chunyu , Zhao Zehua , Jiang Biying , Wang Wentao , Sun Fujing , Zhang Yong , Zhu Yanmei 
Published: January 2025

BackgroundThe therapeutic efficacy of neoadjuvant immunotherapy combined with chemotherapy (Io+Chemo) is superior than chemotherapy alone (Chemo). However, the mechanism of Io+Chemo superiority remains to be further elucidated.MethodsThe study included 128 patients with resectable stage II-III gastric cancer, in which 63 were given neoadjuvant Io+Chemo, and 65 Chemo alone. Patients given Io+Chemo were treated with 2-4 cycles of PD-(L)1 inhibitor (Pembrolizumab, Sintililimab or Nivolumab) with S-1 and oxaliplatin (SOX) or capecitabine and oxaliplatin (XELOX) before surgical resection. Patients given Chemo were treated with 2-4 cycles of SOX or XELOX before surgical resection. Tumor tissues were evaluated for tumor-infiltrating immune cells (TIICs) using immunohistochemistry and QuPath software quantitative analysis, for detecting T, B, NK, plasma cells, and macrophages. The relationship between TIICs and different neoadjuvant treatment regimens and pathological responses was also explored.ResultsCompared with Chemo, Io+Chemo induced higher rates of pathological complete response (33.3 vs. 9.2%, p=0.001) and major pathological response (MPR) (49.2 vs. 30.8%, p=0.033). Compared with Chemo group, density of CD4+(1904.8 vs. 1530), CD8+(1982.9 vs. 1124.4), CD20+(1115.6 vs. 574), CD38+(1580.4 vs. 1128), CD138+(1237.2 vs. 496.4), and CD56+ (596.8 vs. 159) cells was increased 24.5%, 76.4%, 94.4%, 40.1%, and 149.2% respectively, whereas CD163+ macrophages (994.4 vs. 1706) was decreased 41.7% in Io+Chemo group.ConclusionsOur study favors neoadjuvant Io+Chemo over Chemo and reveals Io+Chemo can induce the formation of an immune-activated microenvironment that make Io+Chemo superior to Chemo.
Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89
Authors: Chen Ting , Zhao Yunjiao , Fan Yixuan , Dong Yao , Gai Zhonghui 
Published: January 2025

AimA comprehensive safety assessment of potential probiotic strains was essential for their application in the food industry. This article systematically evaluated the probiotic characteristics, whole-genome sequence analysis and safety of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89.MethodsFirstly, the two strains of lactic acid bacteria selected were identified. Secondly, whole-genome sequencing was performed on LC86 and LC89, and their antibiotic resistance, pathogenicity, and virulence genes were analyzed. We tested various properties of the two strains, included tolerance, cell adhesion, hemolytic activity, catalase activity, gelatin hydrolysis, arginine hydrolysis ability, bile salt hydrolysis capacity, mucin degradation, bioamine, D-/L-lactic acid production and antibiotic susceptibility, to confirm the safety of LC86 and LC89 both in vitro and in vivo. Additionally, we studied the acute toxicity of LC86 and LC89 in mice through a 14-day oral gavage experiment.ResultsThe two strains selected were identified as Lacticaseibacillus paracasei and Lacticaseibacillus casei. The genomes of both LC86 and LC89 were devoid of virulence, antibiotic resistance and pathogenicity genes. LC86 and LC89 exhibited good tolerance to temperature, artificial gastric fluid and artificial intestinal fluid; they were non-hemolytic, their catalase activity, gelatin hydrolysis, arginine hydrolysis and bile salt hydrolysis were all negative. They exhibited the capability to break down proteins and demonstrated sensitivity to a range of antibiotics. The oral LD50 for both LC86 and LC89 in mice was &gt;2 × 1010 CFU/kg.ConclusionThe experimental results above demonstrated the probiotic characteristics and safety of LC86 and LC89, indicating their potential as candidates for probiotics for human and animal applications.