bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase Ib/II study of eribulin in combination with cyclophosphamide in patients with advanced breast cancer
Authors: Gumusay Ozge , Huppert Laura A. , Magbanua Mark Jesus M. , Wabl Chiara A. , Assefa Michael , Chien Amy Jo , Melisko Michelle E. , Majure Melanie C. , Moasser Mark , Park John , Rugo Hope S. 
Published: October 2023

Abstract
Purpose
We hypothesized that eribulin combined with cyclophosphamide (EC) would be an effective combination with tolerable toxicity for the treatment of advanced breast cancer (ABC).

Methods
Patients with histologically confirmed metastatic or unresectable ABC with any number of prior lines of therapy were eligible to enroll. In the dose escalation cohort, dose level 0 was defined as eribulin 1.1 mg/m2 and cyclophosphamide 600 mg/m2, and dose level 1 was defined as eribulin 1.4 mg/m2 and cyclophosphamide 600 mg/m2. Eribulin was given on days 1 and 8 and cyclophosphamide on day 1 of a 21-day cycle. In the dose expansion cohort, enrollment was expanded at dose level 1. The primary objective was clinical benefit rate (CBR), and secondary objectives were response rate (RR), duration of response (DOR), progression-free survival (PFS), and safety.

Results
No dose-limiting toxicities were identified in the dose escalation cohort (n = 6). In the dose expansion cohort, an additional 38 patients were enrolled for a total of 44 patients, including 31 patients (70.4%) with hormone receptor-positive (HR +)/HER2- disease, 12 patients (27.3%) with triple-negative breast cancer (TNBC), and 1 patient (2.3%) with HR + /HER2 + disease. Patients had a median age of 56 years (range 33–82 years), 1 prior line of hormone therapy (range 0–6), and 2 prior lines of chemotherapy (range 0–7). CBR was 79.5% (35/44; 7 partial response, 28 stable disease) and the median DOR was 16.4 weeks (range 13.8–21.1 weeks). Median PFS was 16.4 weeks (95% CI: 13.8–21.1 weeks). The most common grade 3/4 adverse event was neutropenia (47.7%, n = 21). Fourteen of 26 patients (53.8%) with circulating tumor cell (CTC) data were CTC-positive ($$\ge$$
≥
5 CTC/7.5 mL) at baseline. Median PFS was shorter in patients who were CTC-positive vs. negative (13.1 vs 30.6 weeks, p = 0.011).

Conclusion
In heavily pretreated patients with ABC, treatment with EC resulted in an encouraging CBR of 79.5% and PFS of 16.4 weeks, which compares favorably to single-agent eribulin. Dose reduction and delays were primarily due to neutropenia. The contribution of cyclophosphamide to eribulin remains unclear but warrants further evaluation. NCT01554371.
The Cognitive Architecture of Digital Externalization
Authors: Skulmowski Alexander 
Published: October 2023

AbstractThis review is aimed at synthesizing current findings concerning technology-based cognitive offloading and the associated effects on learning and memory. While cognitive externalization (i.e., using the environment to outsource mental computation) is a highly useful technique in various problem-solving tasks, a growing body of research suggests that the offloading of information into the environment (and digital storage in particular) can have negative effects on learning. Based on this review, a model of offloading with cognitive load at its core is developed to summarize when learners offload information. A high intrinsic cognitive load (i.e., a high difficulty), a high extraneous load (i.e., unnecessary design elements), and a low perceived or actual working memory capacity trigger offloading. Crucially, the value attributed to information also affects whether information is externalized. In this model, extraneous cognitive load in the design of technology-enhanced learning acts as a triple barrier: (1) It prevents information from entering working memory, (2) it inhibits information being stored in long-term memory, and (3) it can prevent learners from externalizing information using technology. As a result, in many instances, only the gist of information (or its location) is retained, while learners often gain the illusion of having memorized that information. Furthermore, offloading substantially increases the risk of memory manipulation, potentially posing a societal problem. Consequently, educational approaches should maximize the meaningfulness of the residual information that is often retained in the form of “biological pointers.” In addition, current issues surrounding the use of generative artificial intelligence pertaining to externalization are discussed.
Test performance study to evaluate diagnostic tests for the detection and identification of Xylophilus ampelinus in vine material spiked with cells from X. ampelinus cultures
Authors: Harrison Catherine , Tomlinson Jenny , Brittain Ian , Laurenson Lynn , van den Berg Femke 
Published: October 2023

AbstractA test performance study (TPS) was conducted in 2020 to evaluate performance of serological and PCR-based tests for the detection of Xylophilus ampelinus in homogenised vine samples. In total, 11 labs participated, although there were fewer participants for the serological tests than the PCR-based tests. The panel of samples sent to participants included spiked samples containing 104–108 cfu per ml (serological tests) or 102–106 cfu per ml (PCR-based tests) as well as positive and negative controls. The five PCR-based tests were found to be fit for purpose, with similar performance across a range of metrics (analytical sensitivity, diagnostic sensitivity and specificity, and repeatability and reproducibility assessed in terms of accordance and concordance, respectively). Serological methods (two immunofluorescence tests and two ELISA tests) were found to be less sensitive with regard to both analytical and diagnostic sensitivity. Furthermore, the occurrence of false positives suggests that a positive IF result may not be conclusive when considered in isolation. One of the ELISA tests exhibited much lower analytical and diagnostic sensitivity than the other serological tests and would not be considered suitable for the purpose considered by this TPS.
Assessing soil quality of Italian Western Alps protected areas by QBS-ar: impact of management and habitat type on soil microarthropods
Authors: Fusco Tommaso , Fortini Lorenzo , Casale Francesca , Jacomini Carlo , Di Giulio Andrea 
Published: October 2023

AbstractSoil fauna has a crucial importance for the functioning of ecosystems and their conservation. Soil biota has a role in soil formation and distribution of organic matter, and groups like microarthropods can be used as indicators to assess soil quality and are often employed in monitoring programs. In the present study, the QBS-ar index, an index based on the presence/absence of microarthropod groups, was used to assess the level of soil quality in nine different sampling sites in the “Parco Naturale delle Alpi Marittime” and in the “Parco Naturale del Marguareis” (Cuneo, Piedmont). Forest soils, with different degree of management, and open environments (e.g., grasslands and peatlands) were analyzed comparatively, to investigate whether microarthropod fauna might be influenced by management and habitat type.The results show QBS-ar values are significantly higher in woodland soils compared to grasslands and peatlands (p < 0.05). The latter shows no significant difference between each other, although grasslands show a large range of values (108–214). Forest management does not seem to influence QBS-ar values (183–239), showing stable microarthropod communities both in the managed and unmanaged areas. In addition to this, QBS-ar values do not differ significantly in the different forest coenoses, confirming that woodlands have similar index values (p = 0.7).This study confirms that QBS-ar values in natural areas can vary depending on the environment. It is therefore important to consider clustering habitat types before assessing quality classes for QBS-ar values. Finally, sustainable forest management in the study area does not seem to affect significantly soil microarthropod presence in woodland sites.
Auction design and order of sale with budget-constrained bidders
Authors: Bergmann Ulrich , Konovalov Arkady 
Published: October 2023

AbstractThe presence of financial constraints changes traditional auction theory predictions. In the case of multiple items, such constraints may affect revenue equivalence and efficiency of different auction formats. We consider a simple complete information setting with three financially constrained bidders and two items that have different values common to all the bidders. Using a laboratory experiment, we find that, as predicted by theory, it is more beneficial for the seller to sell the higher value item first. We then show that the first-price sealed-bid auction yields higher revenue than the English auction, with significant differences in learning of equilibrium strategies.
Beliefs, Epistemic Regress and Doxastic Justification
Authors: Nescolarde-Selva J. A. , Usó-Doménech J. L. , Segura-Abad L. , Gash H. 
Published: October 2023

AbstractBy justification we understand what makes a belief epistemologically viable: generally this is considered knowledge that is true. The problem is defining this with a higher degree of precision because this is where different conflicting conceptions appear. On the one hand, we can understand justification as what makes it reasonable to acquire or maintain a belief; on the other, it is what increases the probability that the belief is true. This work tries to prove that beliefs depend on other beliefs that are epistemically justified and that such beliefs are the result of (i.e., they arise from) our privileged intuition of reality. For this, we examine the concept of epistemic regress. Epistemic reasons authorize a proposition P to be the conclusion of an argument in which such reasons function as premises and are vulnerable to epistemic regress. The three most important approaches to epistemic regress are Infinitism, Coherentism and Foundationalism.
Exploring the nature and role of student-to-student talk and questioning among young children in technology and design education
Authors: Fox-Turnbull Wendy 
Published: October 2023

AbstractClassroom conversation between students is complex and used for multiple reasons every day. Student dialogue also allows teachers insight into student's learning. This article presents findings from a qualitative study that used dialogism, a branch of sociocultural theory, to investigate in depth student to student (inter-student) questioning learning in technology in junior primary classrooms in small town in rural South Island, New Zealand. Inter-student dialogue was investigated while students from Year 0–4 undertook a technology unit to design and make props and costumes for their class item in the up-coming school production.In this study insight was gained into aspects of development of student understanding in and of technology through the recording and analysis of inter-student talk, observation, analysis of work samples and focus group interviews with the students and their teachers. It also allowed insight into students’ views of the value of talking with their peers. This study aimed to contribute specifically to the fields of classroom dialogue, student learning, formative assessment and technology education. Three key findings are reported, the first related to teachers’ views of classroom talk. Both were aware of the value of talk in the classroom but struggled to implement in-depth student dialogue for a range of reasons. The second finding focused on students’ views on talk. Initially students recognised that they used questions to ask their teacher, peers, or parents for help, however after the study the data showed that a more sophisticated understanding of dialogue emerged. The third key findings focused on the nature of students’ questions while undertaking technology practice. Findings showed that social interaction played a key role in developing participants’ understanding of technology and that they used questioning to clarify, collaborate, support and defend themselves.
Interaction of Cold Atmospheric Pressure Plasma with Soybean Seeds: Effect on Germination and DNA, Seed Surface Characteristics and Plasma Diagnostics
Authors: Tomeková J. , Švubová R. , Slováková Ľ. , Holubová-Čerevková Ľ. , Kyzek S. , Gálová E. , Zahoranová A. 
Published: October 2023

AbstractThis study investigates the relation between cold atmospheric pressure plasma (CAPP) effect on seeds and the plasma parameters. As a source of CAPP, the diffuse coplanar surface barrier discharge (DCSBD) generated in nitrogen, ambient air, and oxygen at atmospheric pressure was used. Results of germination and the level of DNA damage of soybean seeds (Glycine max L.) treated in plasma and plasma gaseous products showed that the most advantageous is the use of ambient air plasma treatment. The water contact angle (WCA) of samples treated directly in plasma was significantly smaller than that of samples treated with gaseous products. Using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), we did not observe significant changes between the spectra of individual samples, what indicates that there is no damage on the surface of the samples during the treatment, only the binding of polar groups. The method of optical emission spectroscopy (OES) and Fourier transform infrared spectroscopy (FTIR) were used to study the plasma parameters. The most radiant system observed in ambient air and nitrogen plasma is the second positive system of nitrogen $${\text{N}}_{2} \left( {{\text{C}}^{3} \prod _{{\text{u}}} \to {\text{B}}^{3} \prod _{{\text{g}}} } \right)$$

N
2

C

3

∏
u

→

B

3

∏
g

. FTIR measurements showed the presence of reactive oxygen and nitrogen species O3, NO2, N2O, NO, HNO2 depending on the working gas. Finally, it can be assumed that the positive effect of plasma on the seed is caused not only by the individual components of the plasma, but also by their synergistic effect, while the ratio of the individual active particles as well as the plasma exposure to the seeds are important.
“Can I Have a Look?”: The Discursive Management of Victims’ Personal Space During Police First Response Call-Outs to Domestic Abuse Incidents
Authors: Steel Kate 
Published: October 2023

AbstractThe complexities of domestic abuse as both a lived experience and a crime generate unique communicative challenges at the scene of emergency police call-outs. Space is a prominent and complex feature of these ecounters, entailing a juxtaposition of the institutional and the private, whereby frontline officers seek evidence of abuse from victims in the same space in which the abuse occurred. This paper explores how speakers manage one evidentially salient aspect of these encounters: officers’ advancement into victim’s immediate personal space to inspect and photograph their injuries. As compared with the attention dedicated to preserving vulnerable victims’ personal ‘bubble’ of space in formal investigative interviews, first response guidelines allow participants more leeway to adapt their behaviour according to the unpredictable demands of each situation. I present two case studies here which form part of a wider study of first response call-outs to domestic abuse incidents reported to a UK police force. The audio data have been extracted from police body-worn video footage and transcribed, with visual information represented intralinearly. Through conversation analysis, I examine the microinteractional means by which personal space is made relevant and consequential to the unfolding talk, with a focus on how ownership rights and control over the space are (re)constructed discursively. Analysis demonstrates that entering victims’ personal space can be managed in ways that either reinforce their disempowered position or afford them some control. The findings have implications in relation to victims’ potential vulnerability, police-victim relations and the nature of the evidence produced.
Steady-State Flow Through a Subsurface Reservoir with a Displaced Fault and its Poro-elastic Effects on Fault Stresses
Authors: Cornelissen Pavan , Jansen Jan-Dirk 
Published: October 2023

AbstractWe consider steady-state single-phase confined flow through a subsurface porous layer containing a displaced, fully conductive fault causing a sudden jump in the flow path, and we employ (semi-)analytical techniques to compute the corresponding pressures and fault stresses. In particular, we obtain a new solution for the pressure field with the aid of conformal mapping and a Schwarz–Christoffel transformation. Moreover, we use an existing technique to compute the poro-elastic stress field with the aid of inclusion theory. The additional resistance to fluid flow provided by a displaced fault, relative to the resistance in a layer without a fault, is a function of dip angle, fault throw divided by reservoir height, and reservoir width divided by reservoir height. Fluid flow has a larger effect on fault stresses in case of injection than in case of depletion, where injection with up-dip flow results in increased zones of fault slip near the bottom of the reservoir. Opposedly, injection with down-dip flow results in increased slip near the top of the reservoir. An order-of-magnitude estimate of the effect of steady-state flow across displaced faults in the Groningen natural gas reservoir shows that the effect on fault stresses is probably negligible. A similar estimate of the effect in low-enthalpy geothermal doublets indicates that steady-state flow may possibly play a small role, in particular close to the injector, but site-specific assessments will be necessary to quantify the effect.
Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity
Authors: Gazwi Hanaa S. S. , Soltan Osama I. A. , Abdel-Hameed Sanaa M. 
Published: October 2023

AbstractMaintaining a robust immune system and safeguarding the liver from toxins are crucial for overall health. The study aimed to investigate the immunostimulant effects of papaya seed-enriched cakes (CPS) in countering carbon tetrachloride (CCl4)-induced immunocytotoxicity in rats (n= 48). The rats were divided into six groups (8 each): a control group (Group 1), rats fed cakes containing 15% papaya seeds (Group 2 — CPS), rats exposed only to CCl4 (Group 3 — CCl4), rats injected with CCl4 and administered silymarin (Group 4 — CCl4 + S), rats receiving both CCl4 and cakes with papaya seeds (Group 5 — CCl4 + CPS), and rats receiving both CCl4 and silymarin with papaya seed-enriched cakes (Group 6 — CCl4 + CPS + S). HPLC analysis of papaya seeds revealed the presence of ten polyphenol compounds, with quercetin, apigenin, and catechin identified as major flavonoids, along with pyrogallol, ellagic, and gallic acid as predominant phenolic acids. These compounds displayed potent antioxidant activity, attributed to the seeds’ high total phenolic and flavonoid content. The administration of CCl4 significantly affected hematological parameters, liver enzymes, hepatic oxidative stress, levels of TNF-α, IL-6, IgG, as well as IgM. However, rats fed with CPS exhibited mitigation of CCl4-induced toxic effects on hematological parameters and hepatotoxicity. CPS consumption enhanced the antioxidant system, improved inflammatory markers, and immune parameters, restoring them to normal levels. Histopathological analysis confirmed CPS’s ability to reduce CCl4-induced hepatocellular necrosis. Immunohistochemical assessment further revealed reduced immunoreactivity against cleaved caspase-3 expression and increased COX2 immunoreactivity, indicating hepatocellular regeneration in CPS. The combination of CPS and silymarin demonstrated even more notable improvements, suggesting augmented protective impacts against CCl4-induced immunosuppression and hepatotoxicity. In conclusion, CPS exhibited antioxidant properties and effectively protected against CCl4-induced immunotoxicity and hepatotoxicity, with additional benefits observed when combined with silymarin. These findings emphasize the potential health advantages of incorporating papaya seeds into food products, promoting immune system health, and safeguarding against liver damage induced by hazardous agents like CCl4.
The Impact of Early-Stage Chronic Kidney Disease on Weight Loss Outcomes After Gastric Bypass
Authors: Pereira João , Pereira Pedro R. , Andrade Sara , Pereira Sofia S. , Nora Mário , Guimarães Marta , Monteiro Mariana P. 
Published: October 2023

Abstract
Purpose
Weight loss achieved through bariatric metabolic surgery was demonstrated to be effective at reversing chronic kidney dysfunction associated with obesity-related glomerulopathy. However, robust data on how pre-operative kidney status impacts on bariatric metabolic surgery weight loss outcomes is still lacking. The aim of this study was to evaluate the impact of kidney dysfunction on weight loss outcomes after bariatric metabolic surgery.

Methods
Patients with obesity to be submitted to gastric bypass surgery underwent a pre-operative evaluation of creatinine clearance, estimated glomerular filtration rate (eGFR), proteinuria, and albuminuria in 24-hour urine. Body mass index (BMI), % total weight loss (%TWL), and % excess BMI loss (%EBMIL) were assessed at 6 and 12 months after surgery.

Results
Before surgery, patients (N=127) had a mean BMI of 39.6 ± 3.0 kg/m2, and 56.7% (n=72) had a creatinine clearance > 130 mL/min, 23.6% (n= 30) presented proteinuria > 150 mg/24h, and 15.0% (n= 19) presented albuminuria > 30 mg/24h. After surgery, the mean BMI was 27.7 kg/m2 and 25.0 kg/m2 at 6 and 12 months, respectively (p<0.0001). The %TWL was lower in patients with pre-operative eGFR < percentile 25 (34.4 ± 5.8% vs 39.4 ± 4.9%, p=0.0007, at 12 months). There were no significant correlations between weight loss metrics and pre-operative creatinine clearance rate, proteinuria, or albuminuria.

Conclusion
Early-stage chronic kidney disease (G2) has a negative impact on short-term weight loss outcomes after bariatric metabolic surgery, albeit in a magnitude inferior to the clinically relevant threshold.

Graphical abstract
Testability in group theory
Authors: Becker Oren , Lubotzky Alexander , Mosheiff Jonathan 
Published: October 2023

AbstractThis paper is a journal counterpart to [5], in which we initiate the study of property testing problems concerning a finite system of relations E between permutations, generalizing the study of stability in permutations. To every such system E, a group Γ = ΓE is associated and the testability of E depends only on Γ (just like in Galois theory, where the solvability of a polynomial is determined by the solvability of the associated group). This leads to the notion of testable groups, and, more generally, Benjamini–Schramm rigid groups. The paper presents an ensemble of tools to check if a given group Γ is testable/BS-rigid or not.
DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma
Authors: Liu Luzheng , Wu Jincai , Yan Yanggang , Cheng Shoucai , Yu Shuyong , Wang Yong 
Published: October 2023

AbstractDERL2 (derlin 2) is a critical component of the endoplasmic reticulum quality control pathway system whose mutations play an important role in carcinogenesis, including cholangiocarcinoma (CHOL). However, its role and its underlying mechanism have yet to be elucidated. Herein, we revealed that DERL2 was highly expressed in CHOL and considered as an independent prognostic indicator for inferior survival in CHOL. DERL2 ectopically expressed in CHOL cells promoted cell proliferation and colony formation rates, and depleting DERL2 in CHOL cells curbed tumor growth in vitro and in vivo. More interestingly, the knockout of DERL2 augmented the growth-inhibitory effect of gemcitabine chemotherapy on CHOL cells by inducing cell apoptosis. Mechanistically, we discovered that DERL2 interacted with BAG6 (BAG cochaperone 6), thereby extending its half-life and reinforcing the oncogenic role of BAG6 in CHOL progression.