bluuebunny/crossref_metadata_2025_split huggingface dataset:
O gesto de levantar a mão: um olhar sob a perspectiva do contínuo de Kendon
Authors: Oliveira da Silva Eriglauber Edivirgens , Cavalcante Marianne Carvalho Bezerra , Holanda Driely Xavier de 
Published: October 2023

O gesto de levantar a mão é uma produção gestual tão comum nas interações com múltiplos interlocutores para pedir o turno de fala, que foi traduzido como um botão em plataformas de interação online com múltiplos participantes, evidenciando a importância da sua função para esse contexto. Diante disso, o presente estudo busca de forma geral analisar os aspectos linguísticos que envolvem o gesto de levantar a mão, objetivando de forma específica debater teoricamente sobre o gesto de levantar a mão no contexto de sala de aula e classificar as ocorrências desse gesto sob a perspectiva do Contínuo de Kendon (MCNEILL, 2000). Metodologicamente, o estudo se compreende como uma pesquisa descritiva e exploratória de caráter qualitativo interpretativista, organizando os passos da investigação da seguinte forma: 1) levantamento bibliográfico, para o desenvolvimento do debate teórico; 2) seleção e transcrição dos dados, para o desenvolvimento de uma análise classificatória com dados reais e; 3) análise de dados, momento em que a teoria e os dados se encontram. Como embasamento teórico, o atual estudo usufrui de autores que defendem o conceito de matriz gesto-fala (MCNEILL, 1985; MCNEILL, 2000; MCNEILL, 2006; BARROS; CAVALCANTE, 2015; CAVALCANTE, 2019) e autores que investigam o processo interativo professor-aluno no contexto de sala de aula (MARCUSCHI, 2008; SILVA, 2008; SILVA, 2010; DIXON; EGENDOERFER; CLEMENTS, 2009; BÖHEIM et al., 2020). Como resultado, a investigação consegue evidenciar teoricamente que o gesto de levantar a mão pode ser um importante recurso para a manutenção dos turnos de fala em contexto de sala de aula e, durante a análise do gesto sob a perspectiva do Contínuo de Kendon, ficou claro que o gesto de levantar a mão se trata de um emblema gestual.
AI Algorithm to Predict Acute Coronary Syndrome in Prehospital Cardiac Care: Retrospective Cohort Study
Authors: de Koning Enrico , van der Haas Yvette , Saguna Saguna , Stoop Esmee , Bosch Jan , Beeres Saskia , Schalij Martin , Boogers Mark 
Published: October 2023

Background
Overcrowding of hospitals and emergency departments (EDs) is a growing problem. However, not all ED consultations are necessary. For example, 80% of patients in the ED with chest pain do not have an acute coronary syndrome (ACS). Artificial intelligence (AI) is useful in analyzing (medical) data, and might aid health care workers in prehospital clinical decision-making before patients are presented to the hospital.

Objective
The aim of this study was to develop an AI model which would be able to predict ACS before patients visit the ED. The model retrospectively analyzed prehospital data acquired by emergency medical services' nurse paramedics.

Methods
Patients presenting to the emergency medical services with symptoms suggestive of ACS between September 2018 and September 2020 were included. An AI model using a supervised text classification algorithm was developed to analyze data. Data were analyzed for all 7458 patients (mean 68, SD 15 years, 54% men). Specificity, sensitivity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for control and intervention groups. At first, a machine learning (ML) algorithm (or model) was chosen; afterward, the features needed were selected and then the model was tested and improved using iterative evaluation and in a further step through hyperparameter tuning. Finally, a method was selected to explain the final AI model.

Results
The AI model had a specificity of 11% and a sensitivity of 99.5% whereas usual care had a specificity of 1% and a sensitivity of 99.5%. The PPV of the AI model was 15% and the NPV was 99%. The PPV of usual care was 13% and the NPV was 94%.

Conclusions
The AI model was able to predict ACS based on retrospective data from the prehospital setting. It led to an increase in specificity (from 1% to 11%) and NPV (from 94% to 99%) when compared to usual care, with a similar sensitivity. Due to the retrospective nature of this study and the singular focus on ACS it should be seen as a proof-of-concept. Other (possibly life-threatening) diagnoses were not analyzed. Future prospective validation is necessary before implementation.
The role of leptin resistance in the development of thyroid neoplasia
Authors: Miroshnichenko O.S. 
Published: October 2023

Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator. Therefore, an increase in leptin stimulates thyrotropin-releasing hormone secretion, which leads to an increase of thyroid-stimula­ting hormone with normal or slightly elevated levels of thyroxine and triiodothyronine. Leptin imbalance leads to leptin resistance, which develops as a result of impaired sensitivity of hypothalamic receptors to leptin, its penetration through the blood-brain barrier, damage or dysfunction of these receptors, dysfunction of transport proteins accompanied by an increased content of inflammatory mediators that affect leptin receptors and, in turn, damage them. The purpose of the study was to reveal the relationship between hyperleptinemia and leptin resistance in people with different body weight and thyroid nodules. Materials and methods. One hundred and twenty-three patients were examined, who were divided into four groups depen­ding on the body mass index to determine the le­vels of leptin, insulin, and degree of insulin resistance: group 1 — excess body weight (n = 22); group 2 — class 1 obesity (n = 28); group 3 — class 2 obesity (n = 32); group 4 — class 3 obesity (n = 21). The control group consisted of persons with normal body weight (n = 20). Results. It was found that all examined patients had hyperleptinemia (34.5 ng/ml) simultaneously with hyperinsulinemia and insulin resistance (HOMA-IR was 8.3 units). Patients with thyroid neoplasia compared to individuals with normal body weight had significantly higher (by 1.3 times) serum leptin concentrations (p < 0.05; p < 0.001). The research proved that the level of leptine­mia is directly related to the body mass index, waist circumference (r = 0.54; p < 0.001) and hip circumference (r = 0.51; p < 0.001). Conclusions. Among patients with leptin resistance and insulin resistance against the background of obesity of various classes, thyroid neoplasms occur in 28 % of cases. Leptin resistance along with insulin resistance can be considered as independent risk factor for neoplasia. People with abdominal obesity need a mandatory exami­nation of the structural and functional state of the thyroid gland for early detection of nodular neoplasms.
A rare case of medullary carcinoma
Authors: Lishchuk O.Z. , Suslyk Н.I. , Urbanovych A.M. 
Published: October 2023

Medullary thyroid cancer (MTC) accounts for 5–10 % of all thyroid cancers. Most cases (75 %) are sporadic, but the proportion of patients with MTC and a familial predisposition syndrome is the highest among those with any hereditary cancer syndrome (about 25 %), and this possibility should be considered when examining a patient with MTC. Familial syndromes include multiple endocrine neoplasia (MEN) 2A, MEN 2B, and non-MEN familial MTC (familial MTC). Familial MTC syndromes occur in approximately one case per 30,000 of the population. Reduced penetrance and clinical variability are well-established features of many monogenic disorders, particularly phenotypes associated with the RET proto-oncogene. They require an individual assessment of the pathogenic effects and clinical significance of any identified new sequence of the RET va­riant as prerequisites for individual genetic counseling and planning of medical monitoring and treatment. Diagnostic criteria for the disease have been outlined, molecular and genetic aspects have been discussed, and the determination of treatment and further observation has been addressed. The article describes a clinical case of a rare variant of MTC. Treatment of this pathology with radical extrafascial thyroidectomy is under consideration. Given the ineffectiveness of radioiodine and chemotherapy, the main task in the treatment of MTC is early diagnosis, radical surgical intervention, and active monitoring aimed at early detection of disease recurrence. When planning prophylactic thyroidectomy, it is recommended to focus on the stratification of the level of RET gene mutations and the timing of prophylactic thyroidectomy proposed by the American Thyroid Association. The introduction of molecular genetic research into clinical practice for the purpose of diagnosing MTC allows for the objective assessment of the genetic lineage of the disease within a biological family. A timely diagnosis of MTC makes it possible to prescribe an adequate treatment at the stage of preclinical manifestations of the disease, which can significantly increase the quality and duration of life.
Leveraging phenotyping to inform development of process-based plant models
Authors: Jamshidi Sajad , Bogati Sujata , Schafer Sam , Ting To-Chia , Vargas Luis , Wang Diane 
Published: October 2023

Phenotyping plays a crucial role in parameterizing, calibrating, and
evaluating process-based plant models, which can be used to understand
and predict crop behavior under various conditions. This, in turn,
allows for more informed decision-making in agriculture and provides
insights into how crops may respond to changing environmental factors.
Nevertheless, several potential disparities between current plant models
and phenotyping methods exist, which have the potential to undermine the
precision and applicability of these models. These discrepancies
encompass differences in data resolution and scale (both spatial and
temporal) between what is feasibly gathered during phenotyping efforts
and what is required by the models. Additionally, issues related to
compatibility between the traits measured during phenotyping campaigns
and the parameters required for models are prevalent. Furthermore, the
representation of genetic and environmental variability in both models
and phenotyping data is often limited, resulting in a gap between these
two components.
To address these discrepancies, we are developing a new “minimum”
plant model. This model has been designed with strong consideration of
what data can be measured in phenotyping campaigns across multiple
genotypes. While the core model remains straightforward, it has the
capability to simulate essential processes to represent fundamental
plant physiology. Moreover, it has the potential to be integrated into
larger, more comprehensive models or parameterized to suit specific
genotypes. This approach aims to bridge the gap between phenotyping and
crop models, thus enhancing their effectiveness in addressing the
challenges that emerge by utilizing them in broader agricultural
applications.
Long-term efficacy of selective arterial embolisation of renal angiomyolipoma
Authors: Swärd Jesper , Bohlin Karl , Henrikson Olof , Lundstam Sven , Peeker Ralph , Grenabo Bergdahl Anna 
Published: October 2023

Objective: To evaluate the long-term efficacy of selective arterial embolisation in renal angiomyolipoma (AML), with emphasis on tumour shrinkage, potential regrowth and the necessity of supplementary procedures.
Material and methods: A retrospective review of all 58 consecutive embolisations at two institutions, between 1999 and 2018, was performed. Clinical notes, laboratory data and imaging were reviewed.
Results: The overall complication rate was 6.8%, with no Clavien-Dindo grades III–V complications. Kidney function was unaffected by embolisation as measured by creatinine. Median radiological follow-up was 4.8 years (interquartile range [IQR]: 2.8–7.8), and median clinical follow-up was 7.5 years (IQR: 4.7–14.0). Decreasing AML size was observed in 96% of procedures. Maximal shrinkage (30% median diameter decrease; IQR: 15–44) was reached after median 2.2 years (IQR: 0.6–4.8). During follow-up, regrowth occurred in 38% of patients, and four bleeding episodes occurred in three patients with tuberous sclerosis. Growing size and/or rebleeding prompted a redo embolisation in 9% of spontaneous AML and 50% of tuberous sclerosis-associated AML.
Conclusions: Being a well-tolerated treatment with few complications, selective arterial embolisation renders a pronounced size-reduction in most patients with AML, and kidney function is preserved. Regrowth is common, and a radiological follow-up is necessary. Tuberous sclerosis is a risk factor for the need of reintervention.
Psikoedukasi Untuk Menurunkan Stres Warga Binaan di Lembaga Pemasyarakatan
Authors: Putri Adzkia Aunillah , Hapsari Arie , Lestari Rini 
Published: October 2023

Warga binaan di lapas kelas IIB Klaten sering menghadapi berbagai masalah psikologis. Salah satu masalah yang dominan adalah stres. Mereka mengalami tekanan dan ketegangan dalam lingkungan yang tidak familiar, kurangnya kebebasan, isolasi sosial, konflik dengan sesama warga binaan, ketidakpastian mengenai masa depan, serta tekanan dari penjagaan dan aturan di lembaga pemasyarakatan. Stres yang berlebihan dapat menyebabkan gangguan tidur, penurunan nafsu makan, kelelahan, peningkatan ketegangan emosional, dan bahkan dapat memperburuk masalah kesehatan fisik yang sudah ada sebelumnya. Tujuan pengabdian ini adalah memberikan psikoedukasi untuk menurunkan stres pada warga binaan. Subjek sasaran adalah warga binaan kelas IIB Klaten yang berjumlah 10 orang dan berjenis kelamin laki-laki. Psikoedukasi dilakukan pada tanggal 20 dan 23 Februari 2023 selama 180 menit. Stres diukur dengan menggunakan skala DASS 21. Analisis data statistik dilakukan dengan wilcoxon rank test. Hasil menunjukkan psikoedukasi mampu menurunkan stres yang dialami oleh warga binaan.

Kata kunci : lapas, psikoedukasi, stress, warga binaan.
A new ferroptosis-related signature model including messenger RNAs and long non-coding RNAs predicts the prognosis of gastric cancer patients
Authors: Liu Yang , Liu Yanqing , Ye Shujun , Feng Huijin , Ma Lianjun 
Published: October 2023

Abstract

Background and Objectives
Gastric cancer (GC) is among the most malignant tumor types, which causes heavy healthy and economic burden to the people and societies all around the world. Establishment of an effective set of prognostic marker will benefit a lot to the treatment of GC patients clinically. Ferroptosis is a newly identified regulated cell death modality, with tight relevance with GC development. However, its application in the prognosis of GC has not been studied in detail. Deregulated messenger RNA (mRNA) and long non-coding RNA (lncRNA) expression profile in tumor can serve as novel prognostic marker for predicting the survival and cancer relapse in patients.

Methods
We downloaded ferroptosis-related gene expression microarray data, clinicopathologic information and a list of 259 ferroptosis-related genes from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Ferroptosis database, respectively. Then, correlation analysis, univariate and multivariate Cox regression analysis were used to construct a novel prognostic model for GC. Then, we validated the model in the GEO datasets. Finally, we evaluated the differences in immune microenvironment between high- and low-risk groups.

Results
We utilized the ferroptosis-related mRNA and lncRNA profile to successfully construct a prognostic model (incorporating 2 mRNAs and 15 lncRNAs) in GC. Our model, integrating diverse clinical traits and critical factors of GC, showed desirable efficacy in the prognosis of GC patients. This model also manifested effectively in validation by using external patients’ data.

Conclusions
Our study developed a novel ferroptosis-related signature to predict the prognosis of gastric cancer patients. The ferroptosis-related signature had a favorable predictive ability. This model may greatly boost the treatment of GC patients in clinical practice.
IMPLEMENTASI E COMMERCE UNTUK MENINGKATKAN PEMASARAN TAHU BULAT
Authors: Putra Aditya Cahyadi , Setiawan Iwan , Setia Budi 
Published: October 2023

Penelitian dilaksanakan dengan tujuan untuk mengetahui implementasi e commerce dalam peningkatan pemasaran tahu bulat pada agroindustri Cv. Macakal Pangan Sejahtera di Desa Muktisari Kecamatan Cipaku Kabupaten Ciamis.Populasi pada penelitian ini adalah Cv. Macakal Pangan Sejahtera deengan mengambil sampel general mnager perusahaan. Implementasi e commerxe untuk meningkatkan pemasaran tahu bulat pda Cv. Macakal Pangan Sejahtera ini dianalisis dengan cara membandingkan rata-rata omzet menggunakan konvensional dan rata-rata omzet secara keseluruhan selama lima minggu. Hasil penelitian menunjukan secara keseluruhan e commerce dapat menambah omzet sebesar 0,56%. Adapun faktor-faktor yang berpengaruh itu adalah produk yang dijual perusahaan, terutama produk berjenis makanan, ada kekahwatiran konsumen terhadap kualitas produk saat masa pengiriman.
Who’s Afraid of Electrical Stimulation? Let’s Revisit the Application of NMES at the Knee
Authors: Arhos Elanna K. , Ito Naoaki , Hunter-Giordano Airelle , Nolan Thomas P. , Snyder-Mackler Lynn , Silbernagel Karin Grävare 
Published: October 2023

BACKGROUND: Restoring quadriceps strength is essential for successful rehabilitation of knee injuries, but many athletes return to their previous activity with persisting muscle weakness. Strong evidence supports using neuromuscular electrical stimulation (NMES) to improve quadriceps strength; however, there is a lack of widespread clinical implementation. We believe there is a critical need to provide clinical approaches that promote using NMES to improve patients’ quadriceps strength and ensuring clinicians provide high-value rehabilitation care. CLINICAL QUESTION: What is best practice when using NMES to facilitate strength after injury, what are barriers to its use, and how can they be addressed? KEY RESULTS: We discuss the low clinical implementation of NMES, perceived barriers to using NMES, and provide recommendations for setup and dosage parameters for effective use of NMES. CLINICAL APPLICATION: We aim for this commentary, with accompanying videos, to serve as a resource for clinicians who are using commercially available NMES units in clinical practice. J Orthop Sports Phys Ther 2024;54(2):101-106. Epub 31 October 2023. doi:10.2519/jospt.2023.12028
The Merdeka Belajar-based Digital Literacy Skill of Indonesian Language Courses as The Effective Mean to Improve Islamic Characters at Economic Faculty of Universitas Muhammadiyah Semarang
Authors: Yustinah Yustinah 
Published: October 2023

This research is themed on Merdeka Belajar-based Digital Literacy Skill for Indonesian course as an effective facility to improve the Islamic character of Economic Faculty students of Universitas Muhammadiyah Semarang. This research analyzed the Merdeka belajar, self-directed learning–based digital literacy skills in an Indonesian language course, starting from the plan, implementation, and evaluation. The improved Islamic characters of the students were based on honesty (sidiq), trust (amanah), sharing (tabligh), and intelligence (fathonah). The research subjects were the management and accounting students of an Indonesian language course. This descriptive statistic research collected the data by distributing a questionnaire on Google Forms. The results showed the planning aspect obtained a percentage of 59.9%; implementation (57.25%); and evaluation (62.3%). The results showed that the self-directed learning-based digital literacy in the Indonesian language course effectively improved the Islamic characters of the Economic Faculty students of Universitas Muhammadiyah Semarang.
The Influence of Self-Control and the Intensity of Social Media Usage on Adolescent Sexual Behavior
Authors: Salsabiilaa Nadaa , Rini Amanda Pasca , Pratitis Nindia , Rina Amherstia Pasca 
Published: October 2023

The purpose of this study was to determine the simultaneous and partial relationship between self-control and intensity of social media usage with sexual behavior in 110 adolescents. (103 girl and 7 men of SMK Class XI Accounting aged 16-18 years). This research is a correlational quantitative study, using parametric analysis methods with multiple regression analysis techniques. The instruments used in this study are sexual behavior scale, self-control scale, and social media usage intensity scale. The results study show a significant directional relationship, partially self-control and sexual behavior show a significant negative relationship as well as the intensity of social media use and sexual behavior show an insignificant positive relationship. With this it can be concluded that high self-control and low intensity of social media use will lead to low sexual behavior, otherwise low self-control and high social media use lead to high sexual behavior. Sexual behavior is one of the problems that afflicts most adolescents in Indonesia, this behavior is related to genitals or intimate relationships aimed at attracting the attention of the opposite sex. Many factors affect adolescents both from internal factors, namely self-control and external factors, namely the intensity of social media use.
ABSTRAK
Tujuan dari penelitian ini untuk mengetahui hubungan secara simultan dan parsial antara kontrol diri dan intensitas penggunaan media sosial dengan perilaku seksual pada 110 remaja SMK Kelas XI Akuntansi usia 16-18 tahun pengguna media sosial. Penelitian ini merupakan penelitian kuantitatif korelasional, menggunakan metode analisis parametrik dengan teknik analisis regresi berganda. Instrumen yang digunakan dalam penelitian ini yaitu skala perilaku seksual, skala kontrol diri, dan skala intensitas penggunaan media sosial. Hasil dari uji analisis regresi berganda secara simultan menunjukkan hubungan berarah yang signifikan, secara parsial kontrol diri dan perilaku seksual menunjukkan hubungan negatif yang signifikan begitupun dengan intensitas penggunaan media sosial dan perilaku seksual menunjukkan hubungan positif yang tidak signifikan. Dengan ini dapat disimpulkan adanya kontrol diri yang tinggi dan intensitas penggunaan media sosial yang rendah akan menimbulkan perilaku seksual yang rendah, sebaliknya kontrol diri yang rendah dan penggunaan media sosial yang tinggi menimbulkan perilaku seksual yang tinggi. Perilaku seksual salah satu masalah yang menimpa sebagian besar remaja di Indonesia, perilaku ini berkaitan dengan alat kelamin atau hubungan intim yang ditujukan untuk menarik perhatian lawan jenis. Banyak faktor yang mempengaruhi remaja baik dari faktor internal yaitu kontrol diri dan faktor eksternal yaitu intensitas penggunaan media sosial.