bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram prediction model for the risk of intracranial hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke
Authors: Ma Yong , Xu Dong-Yan , Liu Qian , Chen He-Cheng , Chai Er-Qing 
Published: January 2024

Abstract

Background: Hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) leads to poor clinical prognosis, and a reliable predictive system is needed to identify the risk of hemorrhagic transformation after IVT.
Methods: Retrospective collection of patients with acute cerebral infarction treated with intravenous thrombolysis in our hospital from 2018 to 2022. 197 patients were included in the research study. Multivariate logistic regression analysis was used to screen the factors in the predictive nomogram. The performance of nomogram was assessed on the basis of area under the curve (AUC-ROC) of subjects' work characteristics, calibration plots and decision curve analysis (DCA).
Results: A total of 197 patients were recruited, of whom 24 (12.1%) developed HT. In multivariate logistic regression model National Institute of Health Stroke Scale (NIHSS) (OR, 1.362; 95% CI, 1.161 −1.652; P = 0.001), N-terminal pro-brain natriuretic peptide (NT-pro BNP) (OR, 1.012; 95% CI, 1.004 −1.020; P = 0.003), neutrophil to lymphocyte ratio (NLR) (OR, 3.430; 95% CI, 2.082 −6.262; P < 0.001), systolic blood pressure (SBP) (OR, 1.039; 95% CI, 1.009 −1.075; P = 0.016) were the independent predictors of HT which were used to generate nomogram. The nomogram showed good discrimination due to AUC-ROC values. Calibration plot showed good calibration. DCA showed that nomogram is clinically useful.
Conclusion: Nomograms consisting of NIHSS, NT-pro BNP, NLR, SBP scores predict the risk of HT in AIS patients treated with IVT.
Puerarin-containing Rhein-crosslinked Hydrogel for Antibacterial and Anti-Inflammatory Wound Dressings
Authors: Zheng Yu , Li Zhibei , Xu Min , Lu Yongping , Li Xiaofang 
Published: January 2024

Abstract
Wound infections put patients at risk for serious physical harm, even death, and place a heavy financial strain on society. As such, they are one of the most pressing issues facing society today. There is an immediate need for hydrogel dressings with immune-regulating and antibacterial properties. This work is predicated on the two small natural molecules’ complementary physical and efficacious properties. An injectable hydrogel is created by loading the puerarin (PUE) into tyramine-modified hyaluronic acid, then adding rhein (RHE) and H2O2/horseradish peroxidase to facilitate the formation of inter-phenol crosslinks (HA-Tyr-R@P). With its ability to release oxygen and scavenge active oxygen, the developed hydrogel exhibits excellent biocompatibility and modifies the microenvironment favorably. HA-TYR-R@P hydrogels have an antibacterial rate of over 95% and a wound closure rate twice as high as the control group. HA-TYR-R@P hydrogels can inhibit bacteria, reduce inflammation in wounds, encourage wound healing, and have good biocompatibility because of their matched physicochemical characteristics and synergistic therapeutic effects. This work emphasizes the creation of a single-component, multipurpose hydrogel platform that eliminates the need for complex preparations and side effects associated with drugs. Additionally, it provides a comprehensive approach for creating RHE-based hydrogel for wound healing and highlights the importance of natural small molecules in the advancement of biological materials.
MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus
Authors: Wang Tao , Song Dan , Li Xuejuan , Luo Yu , Yang Dianqiang , Liu Xiaoyan , Kong Xiaodan , Xing Yida , Bi Shulin , Zhang Yan , Hu Tao , Zhang Yunyun , Dai Shuang , Shao Zhiqiang , Chen Dahan , Hou Jinpao , Ballestar Esteban , Cai Jianchun , Zheng Feng , Yang James Y. 
Published: January 2024

Abstract
Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the TLR7/8-mediated autoimmune signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated in tissues of lupus prone mice and in the plasma of lupus patients, with its expression levels correlating with the disease activity. miR-574-5p binds to and activates human hTLR8 or its murine ortholog mTlr7 to elicit a series of MyD88-dependent immune and inflammatory responses. These responses include the overproduction of cytokines and interferons, the activation of STAT1 signaling and B lymphocytes, and the production of autoantigens. In a transgenic mouse model, the induction of miR-574-5p overexpression is associated with increased secretion of antinuclear and anti-dsDNA antibodies, increased IgG and C3 deposit in the kidney, elevated expression of inflammatory genes in the spleen. In lupus-prone mice, lentivirus-mediated silencing of miR-574-5p significantly ameliorates major symptoms associated with lupus and lupus nephritis. Collectively, these results suggest that the miR-574-5p-hTLR8/mTlr7 signaling is an important axis of immune and inflammatory responses, contributing significantly to the development of lupus and lupus nephritis.
The Main Features of Food Consumption Mobile Apps in Saudi Arabia: A Scoping Review
Authors: Alammari Duaa , Alruhimi Mayasem , Alkhunein Sarah , Alabdulkarim Aljawharah 
Published: January 2024

Abstract

Background
Food consumption apps seem to be supportive digital tools for facilitating weight management and facilitating healthier eating habits. There is a wide variety of food consumption apps available; however, there is limited evidence that determines the main features of these apps. Therefore, this study aimed to identify the scope of prominent food consumption mobile apps across two commercial app stores (Apple iOS and Google Play) and to determine the main features of the apps systematically.
Methods
This scoping review was conducted across the Apple iOS and Google Play Stories in three steps: (1) an electronic app search, (2) the extraction of data, and (3) the analysis of app characteristics and features.
Results
A total of 99 apps were included, 41 (41%) of which were from the iOS store and 58 (59%) of which were from the Google Play store. Approximately 52% of the apps were rated “4.5 or less”, and 48% of the apps were rated “4.6 and above”. Most of the apps offered more than one language, 81% of which provided 1 to 6 languages, and only 10.1% of the apps offered 7 to 12 languages. We identified a total of 23 features; 29% of the apps had 13 to 18 features, 27% of the apps had 7 to 12 features, and 23% of the apps had 19 + features. In contrast, 18.2% of the apps had 1 to 6 features.
Conclusions
The findings of this review indicate that while a wide range of food consumption apps are available, most apps offer limited features. Therefore, there is a need to introduce unique features, such as entering food by picture or barcode scanning, food composition tables, and tracking of micronutrients, to attract more users. In addition, the number of features was shown to be associated with app ratings. Notably, high ratings may increase the app's visibility; therefore, this factor should be considered by app developers when adding desirable features in the future.
Structure simplification of GNE-140 and discovery of a pyridone based analogue as a potential lead for hLDHA inhibitors
Authors: Mo Wen-Hui , Luo Zhi-Yong , Liu Su-You , Ma Da-You 
Published: January 2024

Abstract
In this paper, taking GNE-140, a structurally complicated hLDHA inhibitor, as a lead compound, 19 simple analogues with a pyrimidone, pyranone or pyridone core were designed and conveniently synthesized. Subsequent biological evaluation indicated that although the pyrimidone core had a weak contribution to hLDHA inhibition, compounds with pyranone or pyridone core exhibited better anti-hLDHA activity. Notably, pyridone-bearing compound 1c showed significant selective inhibition of hLDHA (IC50 = 19.5 ± 2.9 µM) over hLDHB (IC50 = 117.6 ± 13.2 µM). Meanwhile, 1c showed inhibition on the lactate production of lung cancer cell A549. Thus, the result of this study indicated 1c is worthy of further study owing to its convenient synthesis and strong selective hLDHA inhibition.
Oncologists’ perspective on Advance Directives, a French national prospective cross-sectional survey – the ADORE Study
Authors: Cambriel Amélie , Serey Kevin , Pollina-Bachellerie Adrien , Cancel Mathilde , Michalet Morgan , Bay Jacques-Olivier , Bouleuc Carole , Lotz Jean-Pierre , Philippart Francois 
Published: January 2024

Abstract
Background
The foreseeable severity of the prognosis of cancer invites to offer patients the possibility to express their values for care management. However, the prevalence of advance directives(AD) among oncology patients remains low. The aim of this study was to measure the interests and limits to the implementation of AD from the perspective of oncologists.
Methods
French national online survey of hospital-based oncologists. The questionnaire was composed of 5 domains: information on AD, redaction assistance, usage of AD, personal perception of the interest of ADs and clinical particularities of the respondent. Primary outcome was the reported frequency of patients’ information about existence of AD. Secondary outcomes were the measure of factors associated and barriers to the provision of AD information.
Results
410 oncologists (50%) responded to the survey. 75% (n = 308) considered AD as a relevant tool. 36% (n = 149) regularly inform their patients. 25% (n = 102) remain suspicious of this provision, either because they see it as a source of anxiety (n = 211; 60%) or that patients require specific information to write relevant AD (n = 367; 90%). Experience in palliative care was associated with more frequent approach of AD (43% vs 32.3%, p = 0.027). Previous experience of critical care was associated with higher levels of AD distrust (31.5% vs 18.8%, p = 0.003). 68.5% (n = 281) of respondents considered a person of trust more appropriate than AD.
Conclusion
Although AD are mostly considered as a relevant tool, only one third of oncologists regularly inform their patients about them. Uncertainty about the safety and relevance of AD remain high.
Death, Inequality, and the Pandemic in the Nation’s Capital
Authors: Alva Maria L. , Illa Srujana S. , Haber Jaren 
Published: January 2024

Abstract
Background.
Abrupt changes in mortality rates and life expectancy allow us to understand how shocks like COVID-19 can exacerbate health inequalities across groups. We look at Washington, D.C., a major city with a diverse population and long-standing socio-economic divisions. Because DC is a socioeconomically and racially diverse city, the data describing all-cause mortality, cause-specific mortality, and life expectancy provides an informative case study to understand how the pandemic has widened pre-existing gaps across socio-demographic groups.
Methods.
Death certificates for 2015–2021 from the DC Department of Health’s Vital Records and the Census Bureau’s American Community Survey annual estimates are used to compute mortality rate trends by age, sex, race, and residence location. Using the life table approach, we calculate years of life lost (YLL) attributable to COVID-19.
Results.
We find that in 2020 and 2021, there were respectively 1,128 and 629 excess deaths (158 per 100K and 94 per 100K) compared to the annual average over the previous five years, and 689 and 363 deaths in 2020 and 2021, respectively (97 per 100K and 54 per 100K) listing COVID-19 as a cause of death. Accidental and violent deaths increased disproportionately by race. Death rates in 2020 and 2021, compared to the five previous years, were higher for men than women by about 12pp and 5pp and occurred almost entirely among residents 45 and older. Excess deaths between 2020 and 2021 were higher for Black and Hispanic residents by about 286 and 97 per 100K, respectively—with the highest proportional increase (almost twofold) for Hispanics in 2020. Life expectancy in the United States decreased for the first time in 2020 by 1.5 years. In the nation’s capital, the decline in life expectancy was 2.7 years but YLL was highest for Hispanic males and lowest for White females.
Conclusions.
Local-level sociodemographic research like ours reveals intersectional inequalities often obscured by national statistics used in popular and scholarly discourse. The demographic disparities in life expectancy exacerbate existing longevity gaps, which could have severe intergenerational consequences above and beyond the pandemic's immediate morbidity and mortality impacts.
Fluorescent Carbon Dots: Aggregation-Induced Emission Enhancement, Application as probe for CN - and Cr 2 O 7 -2 , sensing strips and bio-imaging agent
Authors: Bhatt Madhuri , Bhatt Shreya , Vyas Gaurav , Raval Ishan , Kumar Anshu , Paul Parimal 
Published: January 2024

Abstract
Fluorescent carbon dots (Trp-CDs) were prepared using tryptophan as precursor and were characterized on the basis of elemental analysis, powder-XRD, IR, Raman spectroscopy, 13C-NMR, UV-Vis, fluorescence and TEM. Trp-CDs exhibit poor fluorescence in 100% water but showed strong Aggregation Induced Emission (AIE) in ethanol and higher alcohols. The anion sensing study of Trp-CD revealed that it selectively detects CN− and Cr2O7 − 2 and from fluorescence quenching titration study, quenching constant, LOD and range of detection were evaluated. The emission life-time of Trp-CD before and after addition of CN− and Cr2O7 − 2 were measured, the decay curve before addition of anion was best fitted with a bi-exponential function with life-time of τ1 2.79 ns (10.74%) and τ2 18.93 ns (89.26%). The mechanistic study revealed that for CN−, the fluorescence quenching is due to its interaction with protons attached to surface functional groups and for Cr2O7 − 2, it is due to inner filter effect (IFE). Sensing strips were prepared by coating Trp-CDs onto various solid surfaces including agarose films and were used for detection of CN− and Cr2O7−. Trp-CD was found to be nontoxic and biocompatible and used as staining agent for Artemia and Bacteria (Bacillus Subtilis, Pseudomonas) and detection of CN− and Cr2O7−.
Chronic pelvic pain in congestion pelvic syndrome: clinical impact and electromyography pelvic floor activity prior and after endovascular treatment
Authors: Corvino Fabio , Giurazza Francesco , Coppola Milena , Tomasello Antonio , Coletta Francesco , Sala Crescenzo , de Martino Bernardo Maria , corvino Antonio , Niola Raffaella 
Published: January 2024

Abstract
Background
To characterize clinical impact of endovascular treatment in Chronic Pelvic Pain (CPP) patients due to Pelvic Congestion Syndrome (PCS) and to assess the diagnostic value of surface electromyography (sEMG) study of pelvic floor musculature (PFM) in PCS patients pre- and post-endovascular treatment. Between January 2019 and July 2023, we studied consecutive patients who were referred for interventional radiology assessment and treatment to a tertiary trauma care Hospital, had evidence of non-obstructive PCS by Magnetic Resonance Imaging (MRI), had performed a sEMG of PFM and underwent endovascular treatment. The primary outcome was clinical, defined as change in symptoms severity after endovascular treatment. The secondary outcome was a difference in the sEMG values pre- and after endovascular therapy.
Results
We included 32 women (mean age 38 years). CPP was the leading symptom in 100% patients, followed by dysmenorrhea (75%) and post-coital pain (68.7%). Endovascular therapy included ovarian vein embolization in 28 patients (87.5%) and internal iliac vein embolization in only 2 patients (6.2%). After a median of 8 (range 6–10) months from endovascular treatment, 29 (90%) of patients reported improvement of the main symptoms, and 15 (46%) were symptom-free. The sEMG values didn’t show a statistical difference pre- and after PCS endovascular treatment.
Conclusions
Endovascular treatment appeared to be highly effective in CPP due to PCS and was associated with a low rate of complication. sEMG study could be useful in revealing alteration of PFM electrophysiology, but a difference pre and after embolization in PCS patient wasn’t demonstrated.
Long-term Outcomes of Surgical Intervention for Symptomatic Aural Atresia and Stenosis
Authors: Yang Runqin , Zhao Yu , Du Miaomiao , Li Rui , Dong Chen , Zha Dingjun , Han Yu 
Published: January 2024

Abstract
Background
This study aims to analyze the clinic features of symptomatic aural atresia and stenosis, and to explore the surgical techniques and postoperative care for aural atresia and stenosis.
Methods
A retrospective analysis on 24 patients with aural atresia (nine patients) or stenosis (15 patients) was conducted. They had done surgery and followed over one years. The basic information, etiologies, symptoms, with or without cholesteatoma were collected. For preventing postoperative restenosis, a plastic sheet with expansive sponge was commonly used as support material. And triamcinolone acetonide was locally injected when a stenotic tendency occurred. Additionally, three representative cases are presented.
Results
The main symptoms were hearing loss, otorrhea and otalgia. Cholesteatoma appeared in 10 patients (66.7%, 10/15) with aural stenosis and six patients (66.7%, 6/9) with aural atresia. After surgery intervention, the air-bone gaps (ABG) in both stenosis and atresia group significantly improved. Restenosis was observed in two patients (8.3%, 2/24) with aural stenosis. The etiologies of them were congenital and acquired, respectively. Tympanic membrane (TM) lateralization occurred in one patient (4.2%, 1/24) with aural atresia. Intralesional injection of triamcinolone acetonide was performed in two patients. One received injection three times and obtained a satisfying outcome. However, the other one failed to continue this treatment and restenosis occurred.
Conclusion
Surgical intervention is a gold standard for symptomatic aural stenosis and aural atresia. To achieve a promising outcome, a plastic sheet with expansive sponge was helpful to support the new EAC and a regular follow-up was mandatory. When a restenosis tendency occurred, intralesional injection of triamcinolone acetonide might benefit to improve it.
Prenatal Utility of Chromosomal Microarray Analysis and Pregnancy Outcomes ： A Cohort Study of 4211 Pregnancies
Authors: Li Huafeng , Hu Juan , Wu Qingyu , Qiu Jigang , Zhang Li , Zhu Jinping 
Published: January 2024

Abstract
With the gradual liberalization of the three-child policy and the development of assisted reproductive technology in China, the population of high-risk pregnancies is gradually increasing. In this study, 4,211 pregnant women who underwent chromosomal microarray analysis(CMA) for high-risk indications were analyzed. The results showed that the overall prenatal detection rate of CMA was 11.4%(480/4211), among which the abnormal chromosome number was 5.82%(245/4211), copy number variants༈CNVs༉was 5.58%༈235/4211༉. Additionally, the detection rate of clinically significant copy number variants (CNVs) was 3.78% (235/4211) and 1.8% (76/4211) for variants of uncertain significance. The detection rate of abnormal chromosomes for pregnant women with AMA was 6.42%༈30/467༉, 6.01%༈50/832༉with high-risk MSS, 39.09%༈224/573༉with high-risk NIPT, 9.21%༈127/1379༉with abnormal ultrasound, and 5.1%༈49/960༉ with other indications. During follow-up, of the 4211 fetuses, 3677 fetuses (3677/4211,87.32%) were normal after birth, 462 fetuses (462/4211,10.97%) were terminated pregnancy, 51 (51/4211,1.21%) fetuses were abnormal after birth, and 21 (21/4211,0.50%) fetuses refused follow-up. These findings indicate that the diagnostic rate of CMA varies significantly among different indications, and can serve as a guide for clinicians to evaluate the application range of CMA technology in prenatal diagnosis.
Heart rate deceleration and acceleration capacities associated with circadian rhythm of blood pressure in essential hypertension
Authors: Wang Jijing , Xu Jinyi , Yang Lihong , Zhang You , Wu Rui , Wang Wentao , Gao Chuanyu 
Published: January 2024

Abstract
Background: This study aimed to investigate the potential association between the circadian rhythm of blood pressure and deceleration capacity (DC)/acceleration capacity (AC) in patients with essential hypertension.
Methods: This study included 318 patients with essential hypertension who underwent 24-hour ambulatory blood pressure monitoring. Patients were categorized into three groups based on the percentage of nocturnal systolic blood pressure (SBP) dipping: the dipper, non-dipper and reverse dipper groups. Baseline demographic characteristics, ambulatory blood pressure monitoring (ABPM) parameters, Holter recordings (including DC and AC), and echocardiographic parameters were collected.
Results: In this study, the lowest DC values were observed in the reverse dipper group, followed by the non-dipper and dipper groups (6.46±2.06 vs. 6.65±1.95 vs. 8.07±1.79 ms, P <.001). Additionally, the AC gradually decreased (-6.32±2.02 vs. -6.55±1.95 vs. -7.80±1.73 ms, P <.001). There was a significant association between DC (r=0.307, P<.001), AC (r=-0.303, P<.001) and nocturnal SBP decline. Furthermore, DC (β = 0.785, P =.001) was positively associated with nocturnal SBP decline, whereas AC was negatively associated with nocturnal SBP (β = -0.753, P<.002). By multivariate logistic regression analysis, deceleration capacity [OR (95% CI): 0.705 (0.594–0.836), p <.001], and acceleration capacity [OR (95% CI): 1.357 (1.141-1.614), p =.001] were identified as independent risk factors for BP nondipper status. The analysis of ROC curves revealed that the area under the curve for DC/AC in predicting the circadian rhythm of blood pressure was 0.711/0.697, with a sensitivity of 73.4%/65.1% and specificity of 66.7%/71.2%.
Conclusions: Abnormal DC and AC density were correlated with a blunted decline in nighttime SBP, suggesting a potential association between the circadian rhythm of blood pressure in essential hypertension patients and autonomic nervous dysfunction.