bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress of Copper‐based Nanocatalysts in Advanced Oxidation Degraded Organic Pollutants
Authors: Li Xuanhao , You Junhua , Li Jingjing , Wang Zhiwei , Zhao Yao , Xu Jingsheng , Duan Mingyi , Zhang Hangzhou 
Published: November 2023

AbstractTo address global pollution caused by contaminants in water bodies, it is crucial to develop an efficient and environmentally friendly treatment process for wastewater from various industries. Advanced oxidation processes (AOPs) have proven to be highly effective in wastewater treatment due to their high oxidation efficacy and the absence of secondary pollutants. Different methods such as ozone, Fenton, electrochemical, photolysis, and sonolysis can be used in AOPs to degrade emerging pollutants that are resistant to conventional methods.In recent years, nanotechnology has emerged as a viable solution, with various nanomaterials being developed for wastewater treatment. Among them, copper‐based nanocatalysts have shown great potential in AOPs. This review focuses on the progress and mechanisms of copper‐based nanocatalysts in wastewater treatment via AOPs. It also discusses the challenges associated with oxidation, electrochemistry, Fenton, and photocatalysis in wastewater treatment processes.Copper‐based nanocatalysts can be modified to enhance their catalytic activity, selectivity, and stability, leading to improved performance in wastewater treatment. They have shown promising results in degrading pollutants like pharmaceuticals, pesticides, and dyes. However, the practical application of these nanocatalysts still faces challenges, including the high cost of synthesis, potential nanoparticle toxicity, and scalability issues. More research is needed to address these challenges and improve the utilization of copper‐based nanocatalysts in wastewater treatment.In addition, Cu‐based catalysts with magnetic properties offer the advantage of easy recovery and reusability in wastewater treatment. They can also be incorporated into catalytic membranes, forming efficient systems for recycling. Heterogeneous catalysts with diverse structures, including ternary or quaternary systems, are widely used. However, challenges remain in identifying suitable coupling pairs and understanding the complex processes involved in constructing heterogeneous interfaces without generating defects. Therefore, a thorough understanding of the catalyst‘s band structure is crucial for developing efficient heterogeneous structures.Furthermore, cost implications of synthesis methods and raw materials should be considered in the preparation of transition metal catalysts, and relevant cost analysis data is needed for optimizing the degradation of pollutants.In conclusion, copper‐based nanocatalysts hold great potential in AOPs for wastewater treatment. With their magnetic properties, Cu‐based catalysts offer the advantage of easy recovery and reusability. However, challenges such as high synthesis costs, nanoparticle toxicity, and scalability issues need to be addressed. Further research is needed to overcome these challenges and optimize the utilization of copper‐based nanocatalysts in wastewater treatment processes.
Stereoselective Double Functionalization of Geminated C(sp3)‐Organodimetallic Linchpins
Authors: Banchini Federico , Leroux Baptiste , Le Gall Erwan , Presset Marc , Jackowski Olivier , Chemla Fabrice , Perez‐Luna Alejandro 
Published: November 2023

AbstractGeminated C(sp3)‐organodimetallics can serve as dinucleophilic linchpins for the rapid assembly of complex molecular structures through two consecutive electrophilic substitution reactions with two different electrophiles. Implementation of these double functionalization sequences in a stereoselective manner to develop tools for asymmetric synthesis has attracted considerable interest from the synthetic community over the last decade. The focus has been put mostly on 1,1‐bimetallic reagents containing boron, zinc or zirconium, and different strategies have been applied for such a purpose, including the diastereoselective transformation of enantioenriched chiral reagents or the enantioselective conversion of achiral or racemic derivatives. Asymmetric catalysis is at stake in most of the approaches developed. In this review article, we highlight the key advances in the development of 1,1‐bimetallic linchpins as tools for asymmetric synthesis, emphasizing the underlying general concepts.
Bisurea‐Based Supramolecular Polymers for Tunable Biomaterials
Authors: Vleugels Marle E. J. , Bosman Rik , da Camino Soligo Piers H. , Wijker Stefan , Fehér Bence , Spiering A. J. H. , Rijns Laura , Bellan Riccardo , Dankers Patricia Y. W. , Palmans Anja R. A. 
Published: November 2023

AbstractWater‐soluble supramolecular polymers show great potential to develop dynamic biomaterials with tailored properties. Here, we elucidate the morphology, stability and dynamicity of supramolecular polymers derived from bisurea‐based monomers. An accessible synthetic approach from 2,4‐toluene diisocyanate (TDI) as the starting material is developed. TDI has two isocyanates that differ in intrinsic reactivity, which allows to obtain functional, desymmetrized monomers in a one‐step procedure. We explore how the hydrophobic/hydrophilic ratio affects the properties of the formed supramolecular polymers by increasing the number of methylene units from 10 to 12 keeping the hydrophilic hexa(ethylene glycol) constant. All bisurea‐based monomers form long, fibrous structures with 3–5 monomers in the cross‐section in water, indicating a proper hydrophobic\hydrophilic balance. The stability of the supramolecular polymers increases with an increasing amount of methylene units, whereas the dynamic nature of the monomers decreases. The introduction of one Cy3 dye affords modified supramolecular monomers, which co‐assemble with the unmodified monomers into fibrous structures. All systems show excellent water‐compatibility and no toxicity for different cell‐lines. Importantly, in cell culture media, the fibrous structures remain present, highlighting the stability of these supramolecular polymers in physiological conditions. The results obtained here motivate further investigation of these bisurea‐based building blocks as dynamic biomaterial.
Dynamic Configuration on a Chiral‐at‐Rhodium Catalyst Featuring a Flexible Tetradentate Ligand
Authors: Tejero Alvaro G. , Castillo Javier , Viguri Fernando , Carmona Daniel , Passarelli Vincenzo , Lahoz Fernando J. , García‐Orduña Pilar , Rodríguez Ricardo 
Published: November 2023

AbstractThe unique dynamic configuration of an enantioselective chiral‐at‐metal catalyst based on Rh(III) and a non‐chiral tetradentate ligand is described and resolved. At room temperature, the catalyst undergoes a dynamic configuration process leading to the formation of two interconvertible metal‐stereoisomers, remarkably without racemization. Density functional theory (DFT) calculations indicate that this metal‐isomerization proceeds via a concerted transition state, which features a trigonal bipyramidal geometry stabilized by the tetradentate ligand. Furthermore, the resolved enantiopure complex shows high catalytic enantioinduction in the Friedel‐Crafts reaction, achieving enantiomeric ratios as high as 99 : 1.
Exploring the Capability of Framework Materials to Improve Cathodes’ Performance for High‐energy Lithium‐ion Batteries
Authors: Konar Rajashree , Maiti Sandipan , Markovsky Boris , Sclar Hadar , Aurbach Doron 
Published: November 2023

AbstractLithiated transition metal oxides are the most important cathode materials for lithium‐ion batteries. Many efforts have been devoted in recent years to improving their energy density, stability, and safety, as demonstrated by thousands of publications. However, the commercialization of several promising materials is limited due to obstacles like stability limitations. To overcome the limitations of energetically high‐voltage or high‐capacity cathode materials, unconventional solutions for their surface engineering were suggested; among them, metal–organic frameworks (MOFs) and zeolites have been employed. MOFs possess favorable characteristics for stabilization goals, including manageable structures, topological control, high porosity, large surface area, and low density. This review article explores promising strategies for improving the electrochemical behavior of favorable cathode materials through surface modifications by using MOFs and zeolites. Investigating the potential of this frameworks‐based surface engineering for high energy density batteries’ electrodes is essential for optimal control of their surface chemistry. It may be highly effective to upgrade the performance of high‐energy cathode materials, thus extending the practical use of very high energy density rechargeable batteries.
Al2O3‐Stabilized Pt Nanozymes: Peroxidase Mimetics and Application in Glucose Detection
Authors: Ma Yawen , Yi Siwen , Gao Chuhan , Yang Man , Feng Dan , Ren Yujing , Ge Huibin 
Published: November 2023

AbstractAs promising alternatives for natural enzymes, much attention has been paid to nanozymes. And our recent study showed that the medium acid sites on the support are the active sites for the adsorption and oxidation of the substrate. Thus, in this work, due to the abundance of medium acid sites, Al2O3 was chosen as the support to prepare Pt/Al2O3 nanozymes. Through the Pt/Al2O3 samples, we further proved that the distribution of the Pt clusters and the amount of the medium acid sites can significantly influence the peroxidase‐like activity. Then the Pt/Al2O3 sample was used for the detection of glucose. And as low as 0.96 μM glucose could be detected with a linear range from 5–60 μM via our method. This work showed the great potential applications of the easily prepared Pt/Al2O3 samples in varieties of simple, robust, and easy‐to‐make analytical approaches in the future.
Enhanced Photocatalytic Oxygen Evolution Using Copper‐Coordinated Perylene Diimide Nanorod Assemblies
Authors: Lee Sukjun , Ju Jeewon , Keum Changjoon , Bang Jieun , Lee Hyesung , Vikneshvaran Sekar , Yoo Hyeri , Park JaeHong , Lee Sang‐Yup 
Published: November 2023

AbstractA crystalline supramolecular photocatalyst is prepared through metal‐induced self‐assembly of perylene diimide with imidazole groups at the imide position (PDI‐Hm). Exploiting the metal‐coordination ability of imidazole, a crystalline assembly of copper‐coordinated PDI‐Hm (CuPDI‐Hm) in a nanorod shape is prepared which displays an outstanding photocatalytic oxygen evolution rate of 25,900 μmol g−1 h−1 without additional co‐catalysts. The imidazole‐copper coordination, along with π–π stacking of PDI frameworks, guides the arrangement of PDI‐Hm molecules to form highly crystalline assemblies. The coordination of copper also modulates the size of the CuPDI‐Hm supramolecular assembly by regulating the nucleation and growth processes. Furthermore, the imidazole‐copper coordination constructs the electric field within the PDI‐Hm assembly, hindering the recombination of photo‐induced charges to enhance the photoelectric/photocatalytic activity when compared to Cu‐free PDI‐Hm assemblies. Small CuPDI‐Hm assembly exhibits higher photocatalytic activity due to their larger surface area and reduced light scattering. Together, the Cu‐imidazole coordination presents a facile way for fabricating size‐controlled crystalline PDI assemblies with built‐in electric field enhancing photoelectric and photocatalytic activities substantially.
Alkylation of Toluene to Mono‐benzylated Toluene over Micro‐mesoporous Zeolite: Effect of Post‐synthetic Treatment and Catalytic Application
Authors: Koshti Hardik , Bandyopadhyay Mahuya , Kumar Mukesh , Tsunoji Nao , Bandyopadhyay Rajib 
Published: November 2023

AbstractPost‐synthetic modification using acid (HNO3) and base (NaOH) are utilised to synthesize hierarchical micro‐mesoporous zeolites with different pore structure. To investigate structural change in materials, X‐ray diffraction (XRD), Scanning electron microscope (SEM), Inductive coupled plasma‐optical emission spectrometry (ICP‐OES), 29Si and 27Al MAS NMR, and N2 adsorption‐desorption isotherms techniques were employed. Acid base titration, and ammonia‐temperature programmed desorption (NH3‐TPD) was performed to evaluate acidic characteristics of materials. As revealed by characterisation, the structure was well preserved after the modification. Hierarchical materials along with parent materials have been evaluated in the toluene alkylation with benzyl alcohol producing mono‐benzylated toluene. All zeolite samples were proved to be catalytically active by their result in the alkylation reaction. Acid treated samples were compared with base treated and parent samples. The results indicate that, base modification significantly increases the mesoporous pore volume in all zeolite as compared to acid modification. Moreover, the highest benzyl alcohol conversion was found to be 98 % in the base modified Beta, with the highest mono‐benzylated toluene selectivity (69 %). Reaction optimization was also studied by altering reaction duration, temperature, and catalyst amount. The reaction products were analysed using Gas Chromatography (GC) and confirmed using Gas chromatography mass spectrometry (GC‐MS).
Stereoselective β‐Arylation of Enol Ethers by a Pd‐Catalyzed Fujiwara‐Moritani Coupling of α‐Oxyacrylates
Authors: Traboulsi Iman , Hachem Mahmoud , Schneider Cédric , Hoarau Christophe 
Published: November 2023

AbstractHerein, Pd(II)‐catalyzed dehydrogenative Heck coupling of 2‐oxyacrylates with arenes for the stereocontrolled production of (Z)‐β‐arylated vinyl ethers is reported. This methodology offers a straightforward and step‐economical route to the synthesis of attractive β‐arylated α‐oxy α,β‐unsaturated carboxylates family which emerged as a relevant class of building blocks with different applications.
Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator‐activated receptor gamma coactivator 1 alpha
Authors: Su Hong , Luo Haodong , Wang Yunhang , Zhao Qin , Zhang Qing , Zhu Ying , Pan Lu , Liu Yuan , Yang Ce , Yin Ying , Tan Botao 
Published: November 2023

AbstractGrowing evidence has proven the efficacy of physical exercise in remyelination and motor function performance after spinal cord injury (SCI). However, the molecular mechanisms of treadmill training on myelin repair and functional recovery after SCI have not yet been fully studied. Here, we explored the effect of treadmill training on upregulating peroxisome proliferator‐activated receptor gamma coactivator 1 alpha (PGC1α)‐mediated myelin repair and functional recovery in a mouse model of thoracic T10 contusion injury. A 4‐week treadmill training scheme was conducted on mice with SCI. The expression levels of oligodendrogenesis‐related protein and PGC1α were detected by immunofluorescence, RNA fluorescence in situ hybridization and western blotting. Transmission electron microscopy (TEM) was used to observe myelin structure. The Basso Mouse Scale (BMS) and CatWalk automated gait analysis system were used for motor function recovery evaluation. Motor evoked potentials (MEPs) were also identified. In addition, adeno‐associated virus (AAV)‐mediated PGC1α knockdown in OLs was used to further unravel the role of PGC1α in exercise‐induced remyelination. We found that treadmill training boosts oligodendrocyte precursor cells (OPCs) proliferation, potentiates oligodendrocytes (OLs) maturation, and increases myelin‐related protein and myelin sheath thickness, thus impelling myelin repair and hindlimb functional performance as well as the speed and amplitude of nerve conduction after SCI. Additionally, downregulating PGC1α through AAV attenuated these positive effects of treadmill training. Collectively, our results suggest that treadmill training enhances remyelination and functional recovery by upregulating PGC1α, which should provide a step forward in the understanding of the effects of physical exercise on myelin repair.
Epileptic activity triggers rapid ROCK1‐dependent astrocyte morphology changes
Authors: Anders Stefanie , Breithausen Björn , Unichenko Petr , Herde Michel K. , Minge Daniel , Abramian Adlin , Behringer Charlotte , Deshpande Tushar , Boehlen Anne , Domingos Cátia , Henning Lukas , Pitsch Julika , Kim Young‐Bum , Bedner Peter , Steinhäuser Christian , Henneberger Christian 
Published: November 2023

AbstractLong‐term modifications of astrocyte function and morphology are well known to occur in epilepsy. They are implicated in the development and manifestation of the disease, but the relevant mechanisms and their pathophysiological role are not firmly established. For instance, it is unclear how quickly the onset of epileptic activity triggers astrocyte morphology changes and what the relevant molecular signals are. We therefore used two‐photon excitation fluorescence microscopy to monitor astrocyte morphology in parallel to the induction of epileptiform activity. We uncovered astrocyte morphology changes within 10–20 min under various experimental conditions in acute hippocampal slices. In vivo, induction of status epilepticus resulted in similarly altered astrocyte morphology within 30 min. Further analysis in vitro revealed a persistent volume reduction of peripheral astrocyte processes triggered by induction of epileptiform activity. In addition, an impaired diffusion within astrocytes and within the astrocyte network was observed, which most likely is a direct consequence of the astrocyte remodeling. These astrocyte morphology changes were prevented by inhibition of the Rho GTPase RhoA and of the Rho‐associated kinase (ROCK). Selective deletion of ROCK1 but not ROCK2 from astrocytes also prevented the morphology change after induction of epileptiform activity and reduced epileptiform activity. Together these observations reveal that epileptic activity triggers a rapid ROCK1‐dependent astrocyte morphology change, which is mechanistically linked to the strength of epileptiform activity. This suggests that astrocytic ROCK1 signaling is a maladaptive response of astrocytes to the onset of epileptic activity.
Detection of the interactions of tumour derived extracellular vesicles with immune cells is dependent on EV‐labelling methods
Authors: Loconte Luisa , Arguedas Davinia , El Rojbin , Zhou Alix , Chipont Anna , Guyonnet Lea , Guerin Coralie , Piovesana Ester , Vázquez‐Ibar José Luis , Joliot Alain , Théry Clotilde , Martín‐Jaular Lorena 
Published: November 2023

AbstractCell‐cell communication within the complex tumour microenvironment is critical to cancer progression. Tumor‐derived extracellular vesicles (TD‐EVs) are key players in this process. They can interact with immune cells and modulate their activity, either suppressing or activating the immune system. Deciphering the interactions between TD‐EVs and immune cells is essential to understand immune modulation by cancer cells. Fluorescent labelling of TD‐EVs is a method of choice to study such interaction. This work aims to determine the impact of EV labelling methods on the detection by imaging flow cytometry and multicolour spectral flow cytometry of EV interaction and capture by the different immune cell types within human Peripheral Blood Mononuclear Cells (PBMCs). EVs released by the triple‐negative breast carcinoma cell line MDA‐MB‐231 were labelled either with the lipophilic dye MemGlow‐488 (MG‐488), Carboxyfluorescein diacetate, succinimidyl ester (CFDA‐SE) or through ectopic expression of a MyrPalm‐superFolderGFP reporter (mp‐sfGFP), which incorporates into EVs during their biogenesis. Our results show that these labelling strategies, although analysed with the same techniques, led to diverging results. While MG‐488‐labelled EVs incorporate in all cell types, CFSE‐labelled EVs are restricted to a minor subset of cells and mp‐sfGFP‐labelled EVs are mainly detected in CD14+ monocytes which are the main uptakers of EVs and other particles, regardless of the labelling method. Furthermore, our results show that the method used for EV labelling influences the detection of the different types of EV interactions with the recipient cells. Specifically, MG‐488, CFSE and mp‐sfGFP result in observation suggesting, respectively, transient EV‐PM interaction that results in dye transfer, EV content delivery, and capture of intact EVs. Consequently, the type of EV labelling method has to be considered as they can provide complementary information on various types of EV‐cell interaction and EV fate.
Cardiomyocyte intercellular signalling increases oxidative stress and reprograms the global‐ and phospho‐proteome of cardiac fibroblasts
Authors: Claridge Bethany , Rai Alin , Lees Jarmon G. , Fang Haoyun , Lim Shiang Y. , Greening David W. 
Published: November 2023

AbstractPathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathological fibroblast reprogramming, our understanding of the downstream molecular players remains limited. Here, we show that cardiac fibroblast activation (αSMA+) and oxidative stress mediated by the secretome of TGFβ‐stimulated cardiomyocytes is associated with a profound reprogramming of their proteome and phosphoproteome landscape. Within the fibroblast global proteome there was a striking dysregulation of proteins implicated in extracellular matrix, protein localisation/metabolism, KEAP1‐NFE2L2 pathway, lysosomes, carbohydrate metabolism, and transcriptional regulation. Kinase substrate enrichment analysis of phosphopeptides revealed potential role of kinases (CK2, CDK2, PKC, GSK3B) during this remodelling. We verified upregulated activity of casein kinase 2 (CK2) in secretome‐treated fibroblasts, and pharmacological CK2 inhibitor TBB (4,5,6,7‐Tetrabromobenzotriazole) significantly abrogated fibroblast activation and oxidative stress. Our data provides molecular insights into cardiomyocyte to cardiac fibroblast crosstalk, and the potential role of CK2 in regulating cardiac fibroblast activation and oxidative stress.
Short‐term outcomes of pancreatoduodenectomy in older individuals over a 9‐year period using real‐world data: A multilevel analysis based on a nationwide administrative database in Japan
Authors: Mori Yasuhisa , Okawara Makoto , Shibao Kazunori , Kohi Shiro , Tamura Toshihisa , Sato Norihiro , Fujino Yoshihisa , Fushimi Kiyohide , Matsuda Shinya , Hirata Keiji 
Published: November 2023

AbstractBackgroundWe aimed to evaluate the short‐term outcomes of pancreatoduodenectomy (PD) in older individuals.MethodsData from the Japanese Diagnosis Procedure Combination database on 62 275 patients who underwent PD from 1 April 2012 to 31 March 2020 were analyzed. Patients were divided into five age groups: <70, 70–74, 75–79, 80–84, and ≥85 years. The associations between postoperative outcomes and age were investigated using multilevel analysis. The mean differences in length of hospital stay and cost were also compared.ResultsThe rate of PD in older individuals increased annually. Compared with the youngest age group (< 70 years), the incidence rate ratios for in‐hospital mortality were 1.52 (95% confidence interval [CI]: 1.30–1.76), 2.07 (1.82–2.37), 2.29 (1.94–2.71), and 2.92 (2.20–3.87) in the 70–74, 75–79, 80–84, and ≥ 85‐year‐old age groups, respectively (all p < .001). Postoperative complications, length of postoperative hospital stay, and cost increased significantly with increasing age.ConclusionsThese real‐world data emphasize the higher levels of morbidity, mortality, and cost in older patients. Careful attention should be paid when considering the indication for PD in older individuals.