bluuebunny/crossref_metadata_2025_split huggingface dataset:
A structural approach to detecting opinion leaders in Twitter by random matrix theory
Authors: Mohammadi Saeedeh , Moradi Parham , Trufanov Andrey , Jafari G. Reza 
Published: December 2023

AbstractThis paper presents a novel approach leveraging Random Matrix Theory (RMT) to identify influential users and uncover the underlying dynamics within social media discourse networks. Focusing on the retweet network associated with the 2021 Iranian presidential election, our study reveals intriguing findings. RMT analysis unveils that power dynamics within both poles of the network do not conform to a “one-to-many” pattern, highlighting a select group of users wielding significant influence within their clusters and across the entire network. By harnessing Random Matrix Theory (RMT) and complementary methodologies, we gain a profound understanding of the network’s structure and, in turn, unveil the intricate dynamics of the discussion extending beyond mere structural analysis. In sum, our findings underscore the potential of RMT as a tool to gain deeper insights into network dynamics, particularly within popular discussions. This approach holds promise for investigating opinion leaders in diverse political and non-political dialogues.
Doctors’ perceptions of using their digital twins in patient care
Authors: Zalake Mohan 
Published: December 2023

AbstractRecent Artificial Intelligence (AI) advancements have facilitated tools capable of generating digital twins of real human faces and voices for interactive communication. In this research, we explore utilizing Digital Twins of Doctors (DTDs) in healthcare because using a doctor’s identity can provide benefits like enhancing the credibility of the health information delivered using computers. DTDs are computer-controlled AI-generated digital replicas of doctors that closely resemble their characteristics. However, there exist limitations, including the social implications of using a doctor’s identity, potential negative impacts on doctor–patient communication, and liability concerns. To ensure a comprehensive understanding of DTD usage in healthcare before widespread adoption, systematic research is essential. As a step towards this direction, in this qualitative research, we report findings from 13 semi-structured interviews with doctors. Our findings indicate that doctors believe DTDs offer benefits by saving doctors’ time through the efficient delivery of repetitive information and personalizing patient care. Moreover, while using a doctor’s identity can enhance credibility, it also raises concerns about using a doctor’s identity to spread potential misinformation. These findings contribute by informing future researchers about doctors’ perspectives on utilizing DTDs in healthcare, guiding the development of effective implementation strategies for responsible DTD integration into healthcare.
Effect of screw angulation on the bending performance of polyaxial locking interfaces: a micro-CT evaluation
Authors: Glowacki Jakub , Bartkowiak Tomasz , Paczos Piotr , Gapinski Bartosz , Mietlinski Patryk , Zawadzki Pawel , Weiss Weronika , Lapaj Lukasz 
Published: December 2023

AbstractPolyaxial locking plates rely on a specific thread-to-thread interface of the screw head and the plate hole. The objective of this study was to evaluate the mechanical performance of single screw interfaces when inserted off-axis and to establish correlations between those parameters and the engagement of the screw head and the plate hole thread. Three polyaxial locking screw systems were inserted into the corresponding plates at various angles (0°, 5°, 10°, and 15° off-axis). The screws were tested until failure. A micro-CT was performed to examine the interface between the plate hole and the screw head. The standard insertion at 0° sustained the greatest maximum bending strength without relocation in the screw hole. Screws inserted at 15° showed a significant reduction in force of up to 44%, 55% and 57%, respectively. Micro-CT analysis of the interface showed a significant loss of thread engagement for off-axis insertion. Polyaxial plates offer additional advantages for off-axis placement of screws. However, this flexibility is related to a significant decrease in both thread engagement and bending strength compared to monoaxial insertion. Regardless the insertion angle, the loss of stability is comparable when screws are placed off-axis. Surgeons are advised to consider off-axis insertion as a salvage option, providing access to better bone stock.
Effect of alkali metals on physical and spectroscopic properties of cellulose
Authors: Refaat Ahmed , Elhaes Hanan , Ibrahim Medhat A. 
Published: December 2023

AbstractA 3-unit cellulose model molecule was built and optimized using DFT B3LYP/6-31G(d,p). The electronic properties of the optimized structure of cellulose were investigated in terms of total dipole moment (TDM), HOMO–LUMO band gap (ΔE), and molecular electrostatic potential (MESP). Cellulose demonstrated a TDM of 9.106 Debye and ΔE of 7.647 eV. The hydrogen atom of the hydroxyl group of the CH2OH group of each cellulose unit was replaced by an alkali metal atom (X) such that the 3-unit cellulose once had 1X atom, then 2X, then 3X atoms, where X = Li, Na or K, both without and with 2, 4 and 6 water molecules (W), respectively, to study also the effect of hydration. Without hydration, the values of TDM decreased for all of the proposed interaction, but increased with hydration, while ΔE decreased in all interactions, confirming that interaction cellulose-alkali metal interaction, especially with hydration, resulted in more reactive structures. Mapping of HOMO–LUMO and MESP indicated significant change in the electron density distribution around cellulose under the effect of interaction with the alkali metals, both with and without hydration. The plots of projected density of states also clearly demonstrated the contribution of each alkali metal as well as water in the molecular orbitals, reflecting their effect on the electronic properties of cellulose and cellulose-alkali metals composites. The theoretical calculations were experimentally verified using FTIR and FT-Raman spectroscopy.
Ternary nanocomposite comprising MnO2, GQDs, and PANI as a potential structure for humidity sensing applications
Authors: Morsy Mohamed , Gomaa Islam , Abd Elhamid Abd Elhamid M. , Shawkey Heba , Aly Mohamed Aly Saad , Elzwawy Amir 
Published: December 2023

AbstractHumidity sensing has been offering a noticeable contribution in different industrial, medical, and agricultural activities. Here, graphene quantum dots doped with polyaniline (PANI) and MnO2 were successfully prepared. The synthesized system is exposed to a set of structural, morphological, and optical investigations. The apparent crystallite size is less than 30 nm, reflecting the nanoscale of the structure, and thus validating the preparation route as evident on XRD pattern. SEM images show a fibrous structure where polyaniline dominates and covers most of the structure’s surface. The evident bands of the FTIR spectrum are designated to the component used in synthesis confirming the chemical structure of the fabricated system. The humidity sensing study of the synthesized structure is carried out through a wide range of relative humidity (RH) levels range of 11–97%. The response and recovery times of the fabricated structure are found to be around 120 and 220s, respectively.
Cucumber grafting on indigenous cucurbit landraces confers salt tolerance and improves fruit yield by enhancing morpho-physio-biochemical and ionic attributes
Authors: Abbas Fazal , Faried Hafiz Nazar , Akhtar Gulzar , Ullah Sami , Javed Talha , Shehzad Muhammad Asif , Ziaf Khurram , Razzaq Kashif , Amin Muhammad , Wattoo Fahad Masoud , Hafeez Aqsa , Rahimi Mehdi , Abeed Amany H. A. 
Published: December 2023

AbstractPakistan is the 8th most climate-affected country in the globe along with a semi-arid to arid climate, thereby the crops require higher irrigation from underground water. Moreover,  ~ 70% of pumped groundwater in irrigated agriculture is brackish and a major cause of secondary salinization. Cucumber (Cucumis sativus L.) is an important vegetable crop with an annual growth rate of about 3.3% in Pakistan. However, it is a relatively salt-sensitive crop. Therefore, a dire need for an alternate environment-friendly technology like grafting for managing salinity stress in cucumber by utilizing the indigenous cucurbit landraces. In this regard, a non-perforated pot-based study was carried out in a lath house to explore indigenous cucurbit landraces; bottle gourd (Lagenaria siceraria) (cv. Faisalabad Round), pumpkin (Cucurbit pepo. L) (cv. Local Desi Special), sponge gourd (Luffa aegyptiaca) (cv. Local) and ridge gourd (Luffa acutangula) (cv. Desi Special) as rootstocks for inducing salinity tolerance in cucumber (cv. Yahla F1). Four different salts (NaCl) treatments; T0 Control (2.4 dSm–1), T1 (4 dSm–1), T2 (6 dSm–1) and T3 (8 dSm–1) were applied. The grafted cucumber plants were transplanted into the already-induced salinity pots (12-inch). Different morpho-physio-biochemical, antioxidants, ionic, and yield attributes were recorded. The results illustrate that increasing salinity negatively affected the growing cucumber plants. However, grafted cucumber plants showed higher salt tolerance relative to non-grafted ones. Indigenous bottle gourd landrace (cv. Faisalabad Round) exhibited higher salt tolerance compared to non-grafted cucumber plants due to higher up-regulation of morpho-physio-biochemical, ionic, and yield attributes that was also confirmed by principal component analysis (PCA). Shoot and root biomass, chlorophylls contents (a and b), activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POX) enzymes, antioxidants scavenging activity (ASA), ionic (↑ K and Ca, ↓ Na), and yield-related attributes were found maximum in cucumber plants grafted onto indigenous bottle gourd landrace. Hence, the indigenous bottle gourd landrace ‘cv. Faisalabad round’ may be utilized as a rootstock for cucumber under a mild pot-based saline environment. However, indigenous bottle gourd landrace ‘cv. Faisalabad round’ may further be evaluated as rootstocks in moderate saline field conditions for possible developing hybrid rootstock and, subsequently, sustainable cucumber production.
Exposure of the US population to extreme precipitation risk has increased due to climate change
Authors: Kim Jungho , Porter Jeremy , Kearns Edward J. 
Published: December 2023

AbstractThe magnitude and frequency of extreme precipitation events in the early twenty-first century have already proven to be increasing at a rate more quickly than previously anticipated. Currently, the biggest consequence of the change in extreme precipitation is the lack of a climate-adjusted national standard taking into account these recent increases that could be used to prevent life and property loss from catastrophic precipitation-driven floods. Here, we address how severe the change in extreme precipitation compares against the current national standard for precipitation climatology (NOAA Atlas 14) and how much of the population is affected by the underestimation of this risk in the contiguous United States (CONUS). As a result, extreme precipitation in the early twenty-first century has outpaced our current national standard in half of CONUS, and the heavy precipitation events experienced recently are quickly becoming a “new normal”, which will increase in severity and frequency in a continually changing climate. Over three-quarters of the U.S. population will likely experience this new normal occurrence of extreme precipitation. As much as one-third of the population is expected to experience the current definition of a 1-in-100-year storm as often as three times in their lifetime. Additionally, the current precipitation standards for designing transportation infrastructure and urban stormwater drainage systems that are built upon Atlas 14 may be insufficient to protect the public's safety and personal/community property from severe flooding. Areas where flood risk is mitigated by operating hydraulic and adaptation structures urgently need to assess the impact of the increased-hourly extreme precipitation and reevaluate their applicable operation rules. Understanding and predicting patterns and the likelihood of short-duration heavy precipitation would be beneficial in preparing for severe precipitation-driven disasters, such as flash floods and landslides, which would happen more frequently in a changing climate. Following the results of this analysis, accelerating the development and dissemination of the next generation of the national standard that has been climatically adjusted to adapt to the new normal is strongly recommended.
Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL
Authors: Laprade William , Bartlett Keirah E. , Christensen Charlotte R. , Kazandjian Taline D. , Patel Rohit N. , Crittenden Edouard , Dawson Charlotte A. , Mansourvar Marjan , Wolff Darian S. , Fryer Thomas , Laustsen Andreas H. , Casewell Nicholas R. , Gutiérrez José María , Hall Steven R. , Jenkins Timothy P. 
Published: December 2023

AbstractSnakebite envenoming is a global public health issue that causes significant morbidity and mortality, particularly in low-income regions of the world. The clinical manifestations of envenomings vary depending on the snake's venom, with paralysis, haemorrhage, and necrosis being the most common and medically relevant effects. To assess the efficacy of antivenoms against dermonecrosis, a preclinical testing approach involves in vivo mouse models that mimic local tissue effects of cytotoxic snakebites in humans. However, current methods for assessing necrosis severity are time-consuming and susceptible to human error. To address this, we present the Venom Induced Dermonecrosis Analysis tooL (VIDAL), a machine-learning-guided image-based solution that can automatically identify dermonecrotic lesions in mice, adjust for lighting biases, scale the image, extract lesion area and discolouration, and calculate the severity of dermonecrosis. We also introduce a new unit, the dermonecrotic unit (DnU), to better capture the complexity of dermonecrosis severity. Our tool is comparable to the performance of state-of-the-art histopathological analysis, making it an accessible, accurate, and reproducible method for assessing dermonecrosis in mice. Given the urgent need to address the neglected tropical disease that is snakebite, high-throughput technologies such as VIDAL are crucial in developing and validating new and existing therapeutics for this debilitating disease.
Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum
Authors: Yamanoi Kazuhiro , Fujii Chifumi , Nakayama Atsushi , Matsuura Noriko , Takatori Yusaku , Kato Motohiko , Yahagi Naohisa , Nakayama Jun 
Published: December 2023

AbstractPyloric gland adenoma (PGA) is a duodenal neoplasm expressing MUC6 and is often associated with high-grade dysplasia and adenocarcinoma. MUC6 secreted from the pyloric gland cells carries unique O-glycans exhibiting terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc). The small peptide trefoil factor 2 (TFF2) is also secreted from pyloric gland cells and binds to αGlcNAc. We recently demonstrated that αGlcNAc serves as a tumor suppressor for gastric neoplasm including PGA, but the significance of TFF2 expression remains unknown. We examined 20 lesions representing low- and high-grade PGA in 22 cases by immunohistochemistry for αGlcNAc, TFF2, MUC6, MUC5AC, MUC2 and p53. αGlcNAc, TFF2 and MUC6 were co-expressed on the cell surface and a dot-like pattern in the cytosol in low-grade PGA lesions. High-grade PGA also expressed MUC6, but reduced αGlcNAc and TFF2 expression. The ratios of αGlcNAc or TFF2 to MUC6 score in high-grade PGA were significantly lower than low-grade PGA (P < 0.001). Co-expression of αGlcNAc-glycosylated MUC6 and TFF2 in PGA suggests the existence of αGlcNAc/TFF2 form complex in PGA cells, a finding consistent with our observations in non-neoplastic Brunner’s gland cells. The decreased αGlcNAc and TFF2 expression are associated with high grade atypical cells, indicative of the malignant potential of PGA.
Domoic acid affects brain morphology and causes behavioral alterations in two fish species
Authors: Beltrán-Solís Kassandra , García-Mendoza Ernesto , Sánchez-Serrano Samuel , López Lus M. 
Published: December 2023

AbstractDomoic acid (DA) produces neurotoxic damage in seabirds and marine mammals when they are exposed to this potent neurotoxin. Other vertebrates are also susceptible to DA intoxication including humans. However, neurobehavioral affectations have not been detected in fish when naturally exposed to DA but only when it is administered intraperitoneally. Therefore, the current idea is that fish are less sensitive to DA acquired under ecologically relevant routes of exposure. Here, we show that oral consumption of DA induces neurobehavioral and histopathological alterations in the brain and heart of totoaba (Totoaba macdonaldi) and striped bass (Morone saxatilis). Lesions were found in both species in the optic tectum and cerebellum after exposure for 7 days to a diet containing 0.776 µgDA g−1. The affectations prevailed chronically. Also, we found that cardiac tissue exhibits lesions and focal atrium melanism. Although affectations of the brain and heart tissue were evident, excitotoxic signs like those described for other vertebrates were not observed. However, the use of standardized behavioral tests (dark/light and antipredator avoidance tests) permitted the detection of behavioral impairment of fish after DA exposure. Pathological and associated behavioral alterations produced by DA can have relevant physiological consequences but also important ecological implications.
Longitudinal changes and variation in human DNA methylation analysed with the Illumina MethylationEPIC BeadChip assay and their implications on forensic age prediction
Authors: Refn Mie Rath , Andersen Mikkel Meyer , Kampmann Marie-Louise , Tfelt-Hansen Jacob , Sørensen Erik , Larsen Margit Hørup , Morling Niels , Børsting Claus , Pereira Vania 
Published: December 2023

AbstractDNA methylation, a pivotal epigenetic modification, plays a crucial role in regulating gene expression and is known to undergo dynamic changes with age. The present study investigated epigenome-wide methylation profiles in 64 individuals over two time points, 15 years apart, using the Illumina EPIC850k arrays. A mixed-effects model identified 2821 age-associated differentially methylated CpG positions (aDMPs) with a median rate of change of 0.18% per year, consistent with a 10–15% change during a human lifespan. Significant variation in the baseline DNA methylation levels between individuals of similar ages as well as inconsistent direction of change with time across individuals were observed for all the aDMPs. Twenty-three of the 2821 aDMPs were previously incorporated into forensic age prediction models. These markers displayed larger changes in DNA methylation with age compared to all the aDMPs and less variation among individuals. Nevertheless, the forensic aDMPs also showed inter-individual variations in the direction of DNA methylation changes. Only cg16867657 in ELOVL2 exhibited a uniform direction of the age-related change among the investigated individuals, which supports the current knowledge that CpG sites in ELOVL2 are the best markers for age prediction.
Noninvasive tracking of mixed venous oxygen saturation via near-infrared spectroscopy cerebral oximetry: a retrospective observational study
Authors: Oh Chahyun , Baek Sujin , Lee Soomin , Shim Man-Shik , Han Sung Joon , Kim Yoon-Hee , Lee Jeong Yeon , Ku Yunseo , Hong Boohwi 
Published: December 2023

AbstractAlthough previous studies have shown correlation between regional cerebral oxygen saturation (rScO2) and mixed venous oxygen saturation (SvO2), there is a lack of pragmatic information on the clinical applicability of these findings, such as tracking ability. We retrospectively analyzed continuous intraoperative recordings of rScO2 and SvO2 obtained from a pulmonary artery catheter and either of two near-infrared spectroscopy (NIRS) devices (INVOS 5100C, Medtronic; O3, Masimo) during off-pump cardiopulmonary bypass (OPCAB) surgery in adult patients. The ability of rScO2 to track SvO2 was quantitatively evaluated with 5 min interval changes transformed into relative values. The analysis included 176 h of data acquired from 48 subjects (26 and 22 subjects for INVOS and O3 dataset, respectively). The area under ROC of the left-rScO2 for detecting change of SvO2 ≥ 10% in INVOS and O3 datasets were 0.919 (95% CI 0.903–0.936) and 0.852 (95% CI 0.818–0.885). The concordance rates between the interval changes of left-rScO2 and SvO2 in INVOS and O3 datasets were 90.6% and 91.9% with 10% exclusion zone. rScO2 can serve as a noninvasive tool for detecting changes in SvO2 levels, a critical hemodynamic measurement.
Prevalence of thyroid dysfunction among Iranian older adults: a cross-sectional study
Authors: Mirahmad Maryam , Mansour Asieh , Moodi Mitra , Safkhani Elaheh , Haghpanah Vahid , Asili Pooria , Fakhrzadeh Hossein , Payab Moloud , Ebrahimpur Mahbube , Khorashadi Masoumeh , Khodabakhshi Huriye , Esmaeili Ali Akbar , Sharifzadeh Gholamreza , Zarban Asghar , Sharifi Farshad , Sajjadi-Jazi Sayed Mahmoud 
Published: December 2023

AbstractThere is limited data on the prevalence of thyroid dysfunction in the older population. This study aimed to determine the prevalence of thyroid dysfunction among a sample of Iranian older adults. A cross-sectional analysis of older adults who aged 60 years and over was conducted. A total of 363 subjects were randomly selected from Birjand longitudinal aging study (BLAS) cohort study. Serum thyroid-stimulating hormone (TSH) level, total thyroxine (T4) and total triiodothyronine (T3) were measured by the enzyme-linked immunosorbent assay (ELISA). Based on thyroid function tests and history of taking medicines used to treat thyroid disorders, participants were classified into the following groups: euthyroid, overt/subclinical hypothyroidism, and overt/subclinical hyperthyroidism. Subsequently, the crude and World Health Organization (WHO) age-standardized prevalence were estimated for different thyroid function categories. A total of 171 men and 192 women, aged 60–94 years, were randomly selected. The crude prevalence of total hypothyroidism was 22.31% (subclinical [18.46%], overt [3.86%]), and that of hyperthyroidism was 1.66% (subclinical [1.38%], overt [0.28%]). The crude prevalence of total thyroid dysfunction was, therefore, 23.97%. A female preponderance was noticed in both total (P-value = 0.035) and overt (P-value = 0.035) hypothyroidism. An increasing trend with age was noticed in the prevalence of total hypothyroidism (P-value = 0.049). Age-standardized prevalence of total hypothyroidism and hyperthyroidism was 26.63% (95% confidence interval [CI] 20.58–33.69%) and 1.11% (95% CI 0.49–2.51%), respectively. A considerable proportion of our study population demonstrated evidence of thyroid dysfunction, particularly subclinical hypothyroidism. Our findings highlight the importance of further investigation of thyroid disorders among older Iranian adults.