bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘I want you to want me’: How owners value cats' choices has implications for cat containment
Authors: Ovenden Kathryn , Bassett Imogen , Sumner Christine L. 
Published: January 2024

Abstract

Globally, cats are a common companion animal. Allowing companion cats to roam away from home can have negative impacts on native wildlife and cat welfare. A more contained cat lifestyle can limit the detrimental impacts of roaming; however, this continues to be an uncommon choice for cat owners in many countries.

Communication strategies that focus on welfare benefits for cats have successfully motivated some owners to prevent their cats from roaming. However, little is known about other factors influencing owners' decisions about roaming, such as the owner–cat relationship and their cat's membership in the local community.

We conducted five focus groups with 31 cat owners in Aotearoa New Zealand to understand these factors.

Using thematic analysis, we identified three major themes that describe how owners view the impacts of cat containment on their relationship with their cat/s. First, finding a balance between enabling and restricting choices to ensure the cat's welfare is at the heart of the owner–cat relationship. Critically, the cat's choice to repeatedly return home reaffirms the owner–cat relationship. Second, striking the right balance in the provision of choice and ensuring welfare are contingent on the cat's characteristics. Owners providing their cat/s with the choice to leave home are perceived to be positively associated with enabling their freedom, independence and curiosity. Third, owners perceived cats to belong in many spaces occupied by humans outside of their property, despite most participants living near populations of significant threatened species.

The choice to allow a cat to roam from home impacts cat welfare, the owner–cat relationship and membership in the local cat, human and wildlife community. Efforts to facilitate the shift to a contained cat lifestyle need to help owners provide choices for their cats that will meet their welfare needs and foster the owner–cat relationship. Locally relevant strategies that consider the owners' views as members of their community will likely be more successful.

Read the free Plain Language Summary for this article on the Journal blog.
Second grade retention: Beliefs, decision‐making styles, and factors involved in the decision process
Authors: Santos Natalie Nóbrega , Monteiro Vera 
Published: January 2024

AbstractGrade retention decisions are high‐risk because this practice can significantly affect students' academic and professional path and their socioaffective development. This study aimed to contribute to a better understanding of second‐grade retention decision‐making by exploring the factors the professionals consider during the retention decision‐making, their beliefs about the effectiveness of grade retention, and their cognitive decision‐making style. The study sets in Portugal, where second‐grade retention is a common practice. One hundred ninety‐four teachers answered an online questionnaire developed for this purpose. Path analysis results suggested that teachers' beliefs and decision‐making styles served as a filter, defining what factors they consider relevant or not to make grade retention decisions. Intuitive experiences seem to inform teachers' grade‐retention decisions, especially when they believe retention is essential for students' success.
Measuring academic skill development for students with autism spectrum disorder using curriculum‐based measurement: A scoping review and call for research
Authors: Keller‐Margulis Milena A. , Mire Sarah S. , Loría Garro Elías S. , Jellinek‐Russo Emily R. , Lozano Ivana , Hut Amanda R. , Luu My‐Linh N. , Izuno‐Garcia Amy K. , Erps Kristen H. , Landry Pierce Lindsey N. , Tan Samantha X. , McNeel Morgan M. , Gardner Scarlett M. , Duran Brenda J. 
Published: January 2024

AbstractSchool‐based service providers must understand how to best measure academic skill development given its key role in improving long‐term outcomes for individuals with autism spectrum disorder (ASD). Curriculum‐based measurement (CBM), which has applications for foundational academic skill areas of reading, writing, and mathematics, may be one way to determine academic intervention targets and progress monitor academic skills for students with ASD, but the extent of the literature base is unknown. Results of this scoping review regarding use of CBM with autistic students indicated few studies, overall. Studies had a wide range of sample sizes and primarily focused on intervention, using CBM as progress or outcome measures. Numerous demographic characteristics and study elements were absent from the literature. Future directions for this area of research and the implications for assessment in response to instruction for students with ASD are presented.
School psychology: Increasing awareness, enhancing policies, and reducing shortages
Authors: Dockweiler Katherine A. , Kaufman Roberta 
Published: January 2024

AbstractThis exploratory mixed methods study investigates the school psychology workforce shortage phenomenon and underlying contributing factors. The development of an Education Specialist school psychology program in the middle of the COVID‐19 pandemic prompted the authors to explore variables impacting awareness of the school psychology profession. State policies were reviewed to identify how many states have adopted the nationally recommended 1:500 ratio for school psychologists. Additionally, undergraduate and postbaccalaureate student knowledge of the work of school‐based mental health professionals, specifically school psychologists, was surveyed. Finally, the authors explore the need for new action frameworks to achieve this awareness and to promote workforce policy development. Based on findings, three key points for practitioners are the need to promote the adoption of policies that align with the 1:500 recommended ratio for school psychologists, increase awareness of the profession with preservice and in‐service educators, and create coordinated training pathways and career opportunities for individuals to become school psychologists.
Epigenetics in obesity: Mechanisms and advances in therapies based on natural products
Authors: Chen Peng , Wang Yulai , Chen Fuchao , Zhou Benhong 
Published: January 2024

AbstractObesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary modifications. In light of the tremendous disease burden and unmet therapeutics, fresh perspectives on pathophysiology and drug discovery are needed. The development of epigenetics provides a compelling justification for how environmental, lifestyle, and other risk factors contribute to the pathogenesis of obesity. Furthermore, epigenetic dysregulations can be restored, and it has been reported that certain natural products obtained from plants, such as tea polyphenols, ellagic acid, urolithins, curcumin, genistein, isothiocyanates, and citrus isoflavonoids, were shown to inhibit weight gain. These substances have great antioxidant potential and are of great interest because they can also modify epigenetic mechanisms. Therefore, understanding epigenetic modifications to target the primary cause of obesity and the epigenetic mechanisms of anti‐obesity effects with certain phytochemicals can prove rational strategies to prevent the disease and develop novel therapeutic interventions. Thus, the current review aimed to summarize the epigenetic mechanisms and advances in therapies for obesity based on natural products to provide evidence for the development of several potential anti‐obesity drug targets.
2‐Deoxyglucose and hydroxychloroquine HPLC‐MS–MS analytical methods and pharmacokinetic interactions after oral co‐administration in male rats
Authors: Sun Dongxiao , Kim Sangyub , Karelia Deepkamal , Deng Yibin , Jiang Cheng , Lü Junxuan 
Published: January 2024

AbstractOur previous work has shown a synergistic tumoricidal efficacy of combining the hexokinase (HK) inhibitor 2‐deoxyglucose (2‐DG) and the autophagy inhibitor chloroquine (CQ) through intraperitoneal injections on HK2‐addicted prostate cancers in animal models. The pharmacokinetic (PK) behaviors of these oral drugs after simultaneous oral administration have not been reported. We developed high‐performance liquid chromatography–tandem mass spectrometry (HPLC‐MS–MS) analytical methods for 2‐DG and the clinically favored drug hydroxychloroquine (HCQ) for sera samples. Using a jugular vein‐cannulated male rat model with serial blood collection before and after a single gavage dose of each drug alone or in combination, we examined their PK metrics for drug–drug interactions. The data demonstrated a rapid and complete separation of 2‐DG from common monosaccharides by HPLC‐MS–MS multi‐reaction monitoring. Application of the HPLC‐MS–MS 2‐DG and HCQ methods to sera samples of nine rats showed a peak time (Tmax) for 2‐DG of 0.5 h after 2‐DG alone or with HCQ and identical post‐peak half‐life of approximately 1 h. With a seemingly bi‐modal time course for HCQ, the Tmax for HCQ alone (1.2 h) was faster than that for the combination (2 h; p = .017). After combination dosing, the peak concentration (Cmax) and area under the curve (AUC0‐4h) of 2‐DG were decreased by 53.8% (p = .0004) and 53.7% (p = .0001), whereas AUC0‐8h for HCQ was decreased by 30.8% (p = .0279) from the respective single dosing. Without changing the mean residence time (MRT0‐∞) of each drug, the combination affected the apparent volume of distribution (Vd) and clearance (CL) of 2‐DG, and CL for HCQ without affecting its Vd. We observed significant negative PK interactions, probably at the intestinal absorption level, between 2‐DG and HCQ taken simultaneously by mouth. Future optimization efforts are warranted for their combination regimen for clinical translation.
Matrine, a potential drug for the treatment of rheumatoid arthritis
Authors: Peng Yaping , Lian Xinqiao , Wang Yan , Li Xin 
Published: January 2024

AbstractRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with a multifaceted pathogenesis involving genetic, epigenetic, and environmental factors. It mainly targets the synovium, leading to synovitis and subsequently bone erosion. Novel effective treatments for RA are imperative. Matrine, the main active constituent of Sophora flavescens Ait (known as Kushen in Chinese medicine), has been used to treat fever, dysentery, hematochezia, jaundice, oliguria, vulvar swelling, asthma, eczema, and inflammatory disorders. Matrine exhibits diverse pharmacological effects, including antitumor, anti‐inflammatory, antifibrotic, and antiviral properties. Animal studies have suggested that matrine mitigates inflammation and reduces RA severity by modulating inflammation‐related expression. Its therapeutic mechanism in RA may involve several signaling pathways, including the phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of the rapamycin, nuclear factor‐κB, Janus kinase/signal transducers and activators of transcription, and mitogen‐activated protein kinase pathways, all of which are associated with various biological processes, such as cell proliferation and differentiation, apoptosis, and immune regulation. Moreover, mitochondrial homeostasis disruption and epigenetic modifications, mediated by long noncoding RNAs, play crucial roles in RA pathogenesis. Experimental evidence suggests that matrine exerts therapeutic effects by modulating mitochondrial homeostasis and long noncoding RNAs. We summarize the molecular mechanisms of matrine in RA treatment to provide theoretical support for expanding its clinical applications to the treatment of RA.
Mechanical termination of a perennial grain crop minimally impacts soil structure, carbon and carbon dioxide emissions
Authors: Kundert Jacob , Rakkar Manbir , Gutknecht Jessica , Jungers Jacob 
Published: January 2024

AbstractIntroductionMechanical termination of crops can negatively affect soil biological, chemical, and structural characteristics. Perennial crops do not require annual termination and can improve these same soil characteristics, which has catalysed interest in the development of new perennial crops. Advanced lines of the perennial grass intermediate wheatgrass (Thinopyrum intermedium [Host] Barkworth and Dewey; IWG) have been bred for increased seed size and marketed as Kernza® perennial grain, but little is known about how this new crop can be terminated for subsequent annual crop production in rotations that enhance agricultural productivity and environmental sustainability.Materials and MethodsFive methods of terminating IWG were tested in Minnesota, USA. Treatments included mechanical tillage using a chisel plow (CHI), undercutter (UND), and disc (DSC), along with no‐till treatments of glyphosate (GLY) and a repeated‐mowing control (CTRL). Treatment effects on IWG mortality, soil carbon dioxide (CO2) emissions, bulk density, aggregate stability, soil carbon stocks and soybean yield were measured.ResultsDaily CO2 fluxes differed by treatment (p < 0.05) on only one of 19 sample dates, and cumulative soil CO2 emissions over the course of the growing season did not differ across treatments. Bulk density decreased relative to baseline in all treatments except CTRL. Aggregate stability remained unchanged in all treatments except CTRL, which increased from the baseline. Soil carbon stocks did not change in any treatment. Soybean yield was highest in GLY but was not significantly different from CHI or UND.ConclusionsSoil structure, soil carbon stocks and soil CO2 emissions were unaffected by tillage and no‐till IWG termination treatments. However, tillage followed by preplanting harrowing proved ineffective at terminating IWG and required subsequent summer herbicide applications. Therefore, additional tillage events may be required to fully terminate IWG when herbicide use is prohibited.
Granulosis Rubra Nasi: A Rare Dermatosis not Limited to Nose
Authors: Mathur Mahesh , Thakur Neha , Jaiswal Sunil , Maharjan Srijana , Shrestha Anjali , Paudel Supriya 
Published: January 2024

Abstract
Granulosis rubra nasi (GRN) is a rare genodermatosis involving the eccrine glands with an unknown aetiology. It is clinically characterized by localized hyperhidrosis, erythema, papules, pustules, and vesicles over central region of face and usually manifests during early childhood. GRN is asymptomatic, spontaneously resolves during puberty, and treatment options have inconsistent results. We hereby present a case of GRN in 38 years female with sites and dermoscopy findings not defined so far.
Safety and Tolerability of Topical Trametinib in Rosacea: Results from a Phase I Clinical Trial
Authors: Wladis Edward J. , Busingye Jacqueline , Saavedra Leahruth K. , Murdico Amy , Adam Alejandro P. 
Published: January 2024

Abstract

Purpose
Overactivation of the mitogen activated kinase pathway has been associated with rosacea. We hypothesised that inhibitors of this pathway can be repurposed to alleviate rosacea symptoms.

Methods
In order to test this hypothesis, we designed a double-blind, randomised, placebo-controlled phase I clinical trial to assess the safety and tolerability of a first-in-kind topical formulation of a MEK kinase inhibitor, trametinib. Subjects applied daily trametinib-containing cream (0.05 mg in 0.5 mL) to one cheek and cream without inhibitor to the other for consecutive 21 days. Skin irritation scores and blood samples were obtained during visits on days 8, 15 and 22.

Results
On analysis of high-performance liquid chromatography, no systemic trametinib absorption was detected during this treatment period. Subjects demonstrated a slight but significant improvement in both cheeks, regardless of drug contents. No adverse effects were reported during this time.

Conclusions
Topical trametinib was well tolerated at a dose of 0.05 mg per day without meaningful systemic absorption or local adverse events. A dose escalation trial is warranted to determine optimal dosing to treat rosacea while avoiding the adverse effects of systemic treatment.
ZIFs‐Derived Hollow Nanostructures via a Strong/Weak Coetching Strategy for Long‐Life Rechargeable Zn–Air Batteries
Authors: Li Shunli , Zhou Yingtang , Xu Chenxi , Wang Lei , Wang Tianzheng , Zhu Baikang , Xu Weijian , Wu Yimin A. , Tao Hengcong 
Published: January 2024

AbstractRecently, zeolitic imidazolate frameworks (ZIFs) composites have emerged as promising precursors for synthesizing hollow‐structured N‐doped carbon‐based noble‐metal materials with diverse structures and compositions. Here, a strong/weak competitive coordination strategy is presented for synthesizing high‐performance electrocatalysts with hollow features. During the competitive coordination process, the cubic zeolitic‐imidazole framework‐8 (Cube‐8)@ZIF‐67 with core–shell structures are transformed into Cube‐8@ZIF‐67@PF/POM with yolk–shell nanostructures employing phosphomolybdic acid (POM) and potassium ferricyanide (PF) as the strong chelator and the weak chelator, respectively. After calcination, the hollow Mo/Fe/Co@NC catalyst exhibits superior performance in both oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). Interestingly, the Mo/Fe/Co@NC catalyst exhibits efficient electrocatalytic performance for Zn–air batteries (ZABs), with a high power density (≈150 mW cm−2) and superior cycling life (≈500 h) compared to commercial platinum/carbon (Pt/C) and ruthenium dioxide (RuO2) mixture benchmarks catalysts. In addition, the density functional theory further proves that after the introduction of Mo and Fe atoms, the adsorption energy with the adsorption intermediates is weakened by adjusting the d‐band center, thus weakening the reaction barrier and promoting the reaction kinetics of OER. Undoubtedly, this study presents novel insights into the fabrication of ZIFs‐derived hollow structure bifunctional oxygen electrocatalysts for clean‐energy diverse applications.
Reprogrammable Magnetic Soft Actuators with Microfluidic Functional Modules via Pixel‐Assembly
Authors: Zhao Xiaoyu , Yao Hongyi , Lv Yaoyi , Chen Zhixian , Dong Lina , Huang Jiajun , Mi Shengli 
Published: January 2024

AbstractMagnetic soft actuators and robots have attracted considerable attention in biomedical applications due to their speedy response, programmability, and biocompatibility. Despite recent advancements, the fabrication process of magnetic actuators and the reprogramming approach of their magnetization profiles continue to pose challenges. Here, a facile fabrication strategy is reported based on arrangements and distributions of reusable magnetic pixels on silicone substrates, allowing for various magnetic actuators with customizable architectures, arbitrary magnetization profiles, and integration of microfluidic technology. This approach enables intricate configurations with decent deformability and programmability, as well as biomimetic movements involving grasping, swimming, and wriggling in response to magnetic actuation. Moreover, microfluidic functional modules are integrated for various purposes, such as on/off valve control, curvature adjustment, fluid mixing, dynamic microfluidic architecture, and liquid delivery robot. The proposed method fulfills the requirements of low‐cost, rapid, and simplified preparation of magnetic actuators, since it eliminates the need to sustain pre‐defined deformations during the magnetization process or to employ laser heating or other stimulation for reprogramming the magnetization profile. Consequently, it is envisioned that magnetic actuators fabricated via pixel‐assembly will have broad prospects in microfluidics and biomedical applications.
F Doping‐Induced Multicomponent Synergistic Active Site Construction toward High‐Efficiency Bifunctional Oxygen Electrocatalysis for Rechargeable Zn–Air Batteries
Authors: Wang Xue , Li Kai , Yang Di , Yang Xiaolong , Xiao Meiling , Zheng Lirong , Xing Wei , Liu Changpeng , Zhu Jianbing 
Published: January 2024

AbstractThe commercialization of rechargeable Zn–air batteries (ZABs) relies on the material innovation to accelerate the sluggish oxygen electrocatalysis kinetics. Due to the differentiated mechanisms of reverse processes, i.e., oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), rationally integrating dual sites for bifunctional oxygen electrocatalysis is prerequisite yet remains challenging. Herein, multicomponent synergistic active sites within highly graphitic carbon substrate are exquisitely constructed, which is accomplished by fluorine (F) modulation strategy. The incorporation of F dopants facilitates pyridinic N formation for anchoring single metal sites, thus guaranteeing the coexistence of sufficient M–Nx sites and metal nanoparticles toward bifunctional oxygen electrocatalysis. As a result, the optimal catalyst, denoted as F NH2‐FeNi‐800, outperforms commercial Pt/C+RuO2 with smaller gap between Ej = 10 and E1/2 (ΔE) of 0.63 V (vs 0.7 V for Pt/C+RuO2), demonstrating its superior bifunctionality. Beyond that, its superiority is validated in homemade rechargeable ZABs. ZABs assembled using F NH2‐FeNi‐800 as the air cathode delivers higher peak power density (123.8 mW cm−2) and long‐cycle lifetime (over 660 cycles) in comparison with Pt/C@RuO2 (68.8 mW cm−2; 300 cycles). The finding not only affords a highly promising oxygen electrocatalyst, but also opens an avenue to constructing multifunctional active sites for heterogeneous catalysts.
Coordination Environment Engineering to Regulate the Adsorption Strength of Intermediates in Single Atom Catalysts for High‐performance CO2 Reaction Reduction
Authors: Wang Maohuai , Kong Lingyan , Lu Xiaoqing , Wu Chi‐Man Lawrence 
Published: January 2024

AbstractThe modulation of the coordination environment of single atom catalysts (SACs) plays a vital role in promoting CO2 reduction reaction (CO2RR). Herein, N or B doped Fe‐embedded graphyne (Fe‐GY), Fe‐nXGYm (n = 1, 2, 3; X = N, B; m = 1, 2, 3), are employed as probes to reveal the effect of the coordination environment engineering on CO2RR performance via heteroatom doping in SACs. The results show that the doping position and number of N or B in Fe‐GY significantly affects catalyst activity and CO2RR product selectivity. In comparison, Fe‐1NGY exhibits high‐performance CO2RR to CH4 with a low limiting potential of −0.17 V, and Fe‐2NGY3 is demonstrated as an excellent CO2RR electrocatalyst for producing HCOOH with a low limiting potential of −0.16 V. With applied potential, Fe‐GY, Fe‐1NGY, and Fe‐2NGY3 exhibit significant advantages in CO2RR to CH4 while hydrogen evolution reaction is inhibited. The intrinsic essence analysis illustrates that heteroatom doping modulates the electronic structure of active sites and regulates the adsorption strength of the intermediates, thereby rendering a favorable coordination environment for CO2RR. This work highlights Fe‐nXGYm as outstanding SACs for CO2RR, and provides an in‐depth insight into the intrinsic essence of the promotion effect from heteroatom doping.