bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRADISI MASYARAKAT TIONGHOA SEBAGAI AJANG WISATA BUDAYA DI KOTA TANJUNG PINANG KEPULAUAN RIAU
Authors: Arnesih Arnesih 
Published: November 2023

Tradisi masyakat tionghoa di Tanjung Pinang kerap dilakukan setiap tahunnya, bahkan hal ini menjadi ajang wisata budaya di kota tanjung pinang hal ini terlihat dari antusias warga dan para turis yang turut menyaksikan dan memeriahkan acara tersebut. Seperti tradisi sembahyang laut, dragon boat dan tradisi kueh bulan. Tradisi ini memiliki keunikan tersendiri dan diyakini berbeda dengan tradisi-tradisi yang lain. Tujuan penelitian ini adalah untuk menjelaskan bagaimana tradisi tersebut menjadi ajang wisata budaya pada masyarakat Tionghoa di Tanjung Pinang. Jenis penelitian ini adalah kualitatif dengan menggunakan metode deskriptif. Keseluruhan data tersebut diperoleh dari wawancara, observasi, dan dokumentasi. Data diperoleh melalui wawancara langsung dan tidak langsung atau bisa didapatkan dengan data-data lain atau dokumen. Informasi dalam penelitian ini adalah wawancara tokoh adat, tokoh agama, tokoh masyarakat. teknik analisis data yang digunakan dengan menggunakan model interaktif dari Miles and Huberman yaitu : data reduction (reduksi data), data display (penyajian data), dan conclusion drawing/verification (gambar kesimpulan dan verifikasi). Hasil penelitian ini menjelaskan bahwa tradisi masyarakat tionghoa kerap dilaksanakan setip tahunnya bahkan telah menjadi ajang wisata budaya di Tanjung Pinang. Seperti tradisi sembahyang laut, Tradisi ini memiliki makna yaitu untuk mendoakan arwa-awah pahlawan Qu Yuan yang memiliki hati bersih, meminta agar diberikan keselamatan pada saat para nelayan yang sedang melaut, dan dipercayai untuk menambahkan rezeki dan kemakmuran bagi masyarakat Tionghoa. Setiap benda-benda yang digunakan pada saat upacara sembahyang laut juga memilki makna, seperti memasang umbul-umbul bendera dan lampion, yang mana lampion memiliki makna yang sangat sakral yaitu untuk melepaskan hal-hal yang negatif dalam diri setiap umat Tionghoa, setiap lampion yang bergantungan berisikan doa dan harapan yang lebih baik dalam menjalankan kehidupan, kemudian penghanyutan kue Pokcang meiliki makna agar ikan-ikan yang ada dilaut tidak memakan tubuh arwah pahlawan China.
PERANCANGAN ULANG PEMANAS SHRINKABLE TUBE MENGGUNAKAN METODE QFD UNTUK MENINGKATKAN OUTPUT DI DEPARTEMEN PRODUKSI DI INDUSTRI MUKAKUNING
Authors: Arifin Zaenal 
Published: November 2023

Perusahaan manufacturing yang beroperasi dibidang transportasi vertikal yang salah satu proses nya perangkaian kabel . dalam keseluruhan proses perangkaian kabel , proses pemanasan shrinkable tube menjadi perhatian penulis untuk dilakukan improvement, proses ini merupakan proses sederhana menggunakan mesin , namun tidak efisien karena terbatas oleh kapasitansya, Sekali memproses membutuhkan waktu 40 detik . Penelitian yang dilakukan, betujuan untuk merancang ulang pemanas shrinkable tube yang lebih efisien sehingga dapat meningkatkan output. Dari permasalahan yang diperoleh, penulis mengambil judul “Perancangan Ulang Pemanas Shrinkable Tube Menggunakan Metode QFD Untuk Meningkatkan Output di Departemen Produksi di Industtri Mukakuning “ Dari hasil analisa, maka rancangan alat tersebut berupa sebuah pemanas yang memiliki kemampuan untuk menghasilkan dan menahan panas dengan baik dengan menggunakan 4 buah lampu halogen sebagai sumber panasnya, berkapasitas 8 pcs material untuk sekali proses dan terbuat dari bahan dan alat yang berkualitas sehingga tahan untuk penggunaan jangka panjang
Efficacy of Empagliflozin in the Treatment of Experimental Myocardial Infarction
Authors: Ivkin D. Yu. , Krasnova M. V. , Okovity S. V. , Karpov A. A. , Kulikov A. A. , Yeletskaya E. I. 
Published: November 2023

Introduction. With the emergence of empagliflozin in the pharmaceutical market, there has been an increase in publications on the primary and secondary pharmacodynamics of the drug, and the list of potential indications for the use of this sodium-glucose co-transporter inhibitor is increasing. Hypotheses about pharmacological effects and mechanisms of their implementation are tested both in large-scale clinical studies and in animal experiments.Aim. The purpose of this work was to study the effectiveness of empagliflozin by echocardiographic, histological and molecular biological analyses at the three most significant points of the dynamic transition from acute myocardial infarction to post-infarction chronic heart failure in laboratory male rats.Materials and methods. The experiment was performed on 60 male outbred rats. Myocardial infarction was modeled in narcotic animals by permanent ligation of the left coronary artery. Based on echocardiographic (EchoCG) study data, animals were randomized to two groups: control infarction: untreated pathology group treated with placebo and pathology group treated with empagliflozin 1 mg/kg per os intragastric daily from the first day of the experiment. At 10, 20 and 30 days after the operation, the animals were also subjected to EchoCG testing, and a group of 10 animals from each group were euthanized for histological examination and molecular analysis.Results and discussion. Empagliflozin use in animals after myocardial infarction modeling contributed to a significant increase in myocardial performance on days 10, 20 and 30, reaching a maximum on day 20 (47.58 ± 1.87 %). The drug promotes long-term preservation of the area of damage to the heart muscle with early formation of mature connective tissue, and also increases myocardial resistance to hypoxia by increasing the amount of HIF-1.Conclusion. Based on the studies carried out, it can be concluded that it is possible to use the sodium-glucose cotransporter type 2 empagliflozin in the formation of post-infarction chronic heart failure in the conditions of normoglycemia.
Potential Use of Melatonin in Periodontal Disease
Authors: Orlova S. V. , Zyryanov S. K. , Nikitina E. A. , Tigay Yu. O. , Orlova A. A. , Grabovsky G. A. 
Published: November 2023

Melatonin is an indoleamine that is secreted not only in the pineal gland, but also in other organs, in particular the salivary glands. Numerous studies show that melatonin levels in the saliva and serum of patients suffering from periodontal disease are reduced, suggesting that it may play an important role in protecting tissues from damage caused by oxidative stress. Melatonin helps regulate the immune response and prevents periodontal tissue damage. The inclusion of melatonin in the periodontal disease treatment regimen increases its effectiveness. Further research is needed to determine the optimal forms and dosing regimens for melatonin.
Remineralizing gel with calcium lactate for the prevention of caries in children
Authors: Brusnitsyna E. V. , Ioschenko E. S. , Gavrilov I. V. , Zakirov T. V. , Kaminskaya L. A. , Ozhgikhina N. V. , Bimbas E. S. 
Published: November 2023

The article presents the results of a single-center open clinical trial of the use of the remineralizing gel «PRESIDENT Minerals gel 0+». The effectiveness of the drug in children in the period of mixed dentition with a compensated form of caries was studied.Materials and methods. The study involved 19 children, mean age 8,3 years. The duration of the study is 1 month.Clinical indices and laboratory parameters were determined: DMF+df, OHI-S, PMA, the degree of enamel electrometry, calcium, glucose, total protein and antioxidant activity of saliva (AOA). Organoleptic properties were determined on a 5-point scale.Results. After one month of using the remineralizing gel, a decrease in the hygiene index by 23,27%, a decrease in the electrometric evaluation of enamel by 15,58% were revealed. In saliva, a decrease in the level of protein by 33,13% and an increase in the content of calcium by 53,33% were revealed. The organoleptic properties of the gel were evaluated on a five-point scale at 4,31±0,22 points.Conclusion. «PRESIDENT 0+ Minerals gel» with calcium lactate and hydroxyapatite has a remineralizing effect, good organoleptic properties and can be recommended for caries prevention in children.
Study of inflammatory markers and their diagnostic effectiveness in patients with COVID-19 patients
Authors: Putkov S. B. , Davydova N. V. , Kazakov S. P. 
Published: November 2023

The study examines the relationship between the levels of laboratory serum markers of inflammation and severity in patients with COVID-19. The purpose of the study. To investigate the mechanisms of interaction of inflammatory markers and calculate their diagnostic effectiveness in patients with COVID-19 in assessing the severity and prognosis of the disease. Materials and methods. We conducted a retrospective cohort study of the blood of 104 patients aged 20–84 years admitted to the hospital. The patients were divided into groups: group 1 – mild degree (n = 14); group 2 – moderate degree (n = 50); group 3 – severe degree (n = 40). The concentration of procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), presepsin (PSP), proadrenomedullin (MRpro-ADM), ferritin (F), components of the complement system C 3, C 4 were determined using original reagent kits on automated systems. Results. In the obtained results of primary studies in the general group, an increase in the average values of inflammatory markers from reference values was noted. Correlation analysis revealed reliable direct medium and weak connections between markers of inflammation. Thresholdvalues were obtained when comparing groups with mild and moderate severity for MRpro-ADM, PCT, F, and in the group with moderate and severe severity for PCT, PSP, CRP and IL-6, above which we can talk about the transition of the disease to a moderate and severe degree of the disease, respectively. Conclusions. Determination of concentration and threshold values with parameters of diagnostic sensitivity of acute-phase markers of inflammation serves as an additional criterion for assessing the severity of the disease, prognosis, monitoring of treatment, but not specific diagnosis and allows you to understand the mechanisms of the immune system response.
Chronic heart failure patient and COVID-19: Focus on laboratory markers of myocardial damage
Authors: Bagisheva N. V. , Moiseeva M. V. , Mordyk A. V. , Streltsova V. V. , Antipova E. P. 
Published: November 2023

The aim of the study. To determine the severity of the current COVID-19 in patients with CHF. Materials and methods. The study included data from 98 patients diagnosed with COVID-19 in combination with CHF. The data on the duration of hospitalization, the severity of the lesion, the dynamics of the level of laboratory parameters are analyzed. Results. In 68 patients with CHF 2A, stage I of CHF in 27 patients and in 3 patients – stage 0. CHF of functional class I – 23 patients, FC II – 73 patients, FC III – 2 patients. The average duration of hospitalization was 15 days. Blood saturation (SpO2) in the range of 95–100 % was determined in 75 patients, 90–95 % – in 20 people, less than 90 % – in 3 patients. In 42.86 % of patients, an increase in the level of D-dimer was detected according to laboratory studies. Conclusions. Patients 60 years and older with CHF 2A and FC II with pronounced clinical symptoms are at risk of severe infection requiring hospitalization. Concomitant diseases of the cardiovascular system increase the duration of hospitalization.
Problem of determining vitamin D status
Authors: Klimenkova O. A. , Mezina E. Yu. , Krikunova D. M. , Pashkova V. P. , Berestovskaya V. S. 
Published: November 2023

Background. Recently, the demand for the measurement of vitamin D has been growing at a rate outrunning other types of laboratory tests. However, estimates of the prevalence of this nutrient status among population groups vary widely, based on target levels considered adequate or optimal for maintaining good health. The lack of a unified approach to stratifying the values of vitamin D in a patient’s blood creates difficulties in assessing the status of this nutrient. Objective. Stratification of vitamin D results in pediatric and adult patients examined between 2017 and 2022 at the St. Petersburg Consultative and Diagnostic Centre for Children, using criteria of different research groups and professional societies. Materials and methods. Vitamin D measurements were carried out using an immunochemical analyzer from January 2017 to December 2022 in 15,946 samples from children and 9,163 from adults. Results. Using stratification criteria proposed by various research groups and professional societies, the range of vitamin D deficiency in 2017–2019 ranged from 3.0 % to 63.9 % in children and from 2.4 % to 81.7 % in adults. In 2020–2022 deficient status was less common for all criteria: from 0.2 % to 51.2 % in children and from 0.1 % to 42.5 % in adults. An inverse relationship was noted for vitamin D levels associated with risk of harm. In 2017–2019 such values were detected in 1.0 %, in 2020–2022 in 2.8 % of children. In adults, similar rates increased from 1.8 % in 2017–2019 up to 3.5 % in 2020–2022. Conclusions. The wide variation in approaches reflects the uncertainty in research findings, recommendations, and guidelines involving vitamin D. Consensus on vitamin D thresholds will help arrive at the most likely conclusions from an evidence-based clinical perspective when establishing an association between a risk factor and an outcome.
Internet-based cognitive-behavioral therapy is effective in reducing depressive symptomatology in type 1 diabetes: results of a randomized controlled trial
Authors: Carreira Mónica , Ruiz de Adana Ma Soledad , Pinzón José Luis , Anarte-Ortiz María Teresa 
Published: November 2023

ObjectiveDepression in people with diabetes is associated with poorer health outcomes. Although web programs integrating cognitive-behavioral therapy with diabetes education have shown good results, no similar approach has been implemented in Spain. This aim of this study was to administer an Internet-based cognitive-behavioral therapy program (CBT) for the treatment of mild-moderate depressive symptomatology in individuals with type 1 diabetes (WEB_TDDI1 study) and evaluate the efficacy of this program.Research design and methodsA pre-post randomized controlled study was conducted. The sample comprised 65 people with type 1 diabetes and mild-moderate depressive symptoms: 35 treatment group (TG) and 30 control group (CG). The following effects of the nine-session program were analyzed: depression (Beck Depression Inventory Fast Screen, BDI-FS), metabolic variables (glycosilated hemoglobin, HbA1c), and other psychological variables including anxiety (State Trait Anxiety Inventory, STAI), fear of hypoglycemia (Fear of Hypoglycemia Questionnaire, FH-15), distress (Diabetes Distress Questionnaire (DDS), quality of life (Diabetes Quality of Life Questionnaire, DQOL),and treatment adherence (Diabetes Self-Care Inventory-Revised questionnaire, SCI-R).ResultsAt the end of the treatment program, only 28 people were evaluated (TG=8; CG=20). However, a significant reduction was found in both groups in BDI-FS and STAI-T scores, which was significantly greater in the TG. Significant improvements were also found in the TG in DQOL, FH-15, DDS and SCI-R scores. The percentage change in these variables was also statistically significant in the TG versus the CG. However, no significant results were found in HbA1c.ConclusionsThe Internet-based cognitive-behavioral therapy program for the treatment of mild-moderate depressive symptomatology in people with type 1 diabetes (WEB_TDDI1 study) is effective in reducing depressive symptomatology in the sample that completed the study. Positive results are also produced in other variables associated with depression in this population such as diabetes-related distress, trait anxiety, fear of hypoglycemia, quality of life, and adherence to diabetes treatment. Although new studies would be necessary to support the results of this platform, the results obtained are positive and support the use of this platform as an appropriate treatment for this population.Clinical trial registrationClinicalTrials.gov; identifier NCT03473704.
Role of atrial high-rate episodes in stratifying thromboembolic risk: a multiple cut-off diagnostic meta-analysis
Authors: Saglietto Andrea , Ballatore Andrea , Griffith Brookles Carola , Xhakupi Henri , De Ferrari Gaetano Maria , Anselmino Matteo 
Published: November 2023

AimsDespite the high prevalence rate of atrial high-rate episodes (AHREs) detected using cardiac implantable electronic devices (CIEDs), clinical guidelines and consensus documents have disagreed on a universal AHRE definition and a temporal cut-off related to subsequent thromboembolic events. This diagnostic test accuracy meta-analysis aims to derive the optimal temporal threshold of clinically significant AHREs from the available literature.MethodsThe PubMed/MEDLINE and EMBASE databases were screened for studies on CIED patients reporting the incidence of thromboembolic events related to at least one AHRE temporal cut-off. A total of 23 studies were included: 19 considering the longest single AHRE and four the AHRE burden, respectively. A random-effect diagnostic test accuracy meta-analysis with multiple cut-offs was performed. Two analyses were performed according to the AHRE temporal cut-off subtype (longest episode vs. cumulative burden).ResultsThe analysis on the longest single AHRE indicated 0.07 min as the optimal duration to differentiate AHRE associated or not with thromboembolic events [sensitivity 65.4% (95% CI 48.8%–79.0%), specificity 52.7% (95% CI 46.0%–59.4%), and area under the summary receiver operating characteristic curve (AUC-SROC): 0.62]. The analysis on AHRE burden indicated 1.4 min as the optimal cut-off [sensitivity 58.2% (95% CI 25.6%–85.0%), specificity 57.5% (95% CI 42.0%–71.7%), and AUC-SROC 0.60]. A sensitivity analysis excluding patients with a history of atrial fibrillation and including high-quality studies only yielded similar results.ConclusionThe presence of AHRE, rather than a specific duration, relates to an increased, albeit low, thromboembolic risk in CIED patients. Any AHRE should constitute an additional element in patient-specific thromboembolic risk assessment.
Assessment of trace elements in the long-term banana cultivation field’s soil
Authors: Islam Md Saiful , Islam Md Towhidul , Ismail Zulhilmi , Islam Abu Reza Md Towfiqul , Khan Rahat , Hasan Fakhrul , Kabir Md Humayun , Ezewudo Bede Izuchukwu , Ibrahim Khalid A. , Idris Abubakr M. 
Published: November 2023

This work assesses the contamination of trace elements (Cr, Cu, Ni, As, Zn Cd, Mn, Fe, and Pb) in soil and different tissues of the banana plant (Musa spp.), the ecological risks of trace elements using various indices, and the probable health risks using a chemometric approach. Soil and different banana plant tissues were collected from banana fields around the industrial area of the capital of old Pundranagar (the earliest urban archaeological location), Bangladesh. Samples were digested by acid digestion, and trace elements were measured by inductively coupled plasma spectrophotometer (ICP-MS). The concentrations of Cr, Ni, Cu, As, Cd, Pb, Fe, Mn, and Zn in soil ranged from 1.50–61.7, 2.42–87.4, 2.00–100.8, 0.25–31.2, 0.10–12.7, 0.60–91.8, 11330–23782, 8.69–105.9, and 7.50–125.9 mg/kg, respectively. The mean concentrations of trace elements in four tissues descend in order of roots &gt; leaves &gt; stems &gt; fruits. The abundances of trace elements varied in both soil and plant samples, which apparently occurred due to the variations of soil parent materials and the excessive use of agrochemicals for long-term banana cultivation. The soil exhibited a moderate to high degree of contamination with trace elements, and Cr, Pb, Zn, Cd, and As mainly originated from anthropogenic sources. Both non-cancer and cancer risks were perceived due to Cr and As exposure from the fruit tissue of banana plants in the study area.
A novel multistage antigens ERA005f confer protection against Mycobacterium tuberculosis by driving Th-1 and Th-17 type T cell immune responses
Authors: Fan Xueting , Zhao Xiuqin , Wang Ruibai , Li Machao , Luan Xiuli , Wang Ruihuan , Wan Kanglin , Liu Haican 
Published: November 2023

IntroductionTuberculosis (TB) is a major threat to human health. In 2021, TB was the second leading cause of death after COVID-19 among infectious diseases. The Bacillus Calmette–Guérin vaccine (BCG), the only licensed TB vaccine, is ineffective against adult TB. Therefore, there is an urgent need to develop new effective vaccines.MethodsIn this study, we developed a novel multistage subunit vaccine (ERA005f) comprising various proteins expressed in metabolic states, based on three immunodominant antigens (ESAT-6, Rv2628, and Ag85B). We utilized the E. coli prokaryotic expression system to express ERA005f and subsequently purified the protein using nickel affinity chromatography and anion exchange. Immunogenicity and protective efficacy of ERA005f and ERA005m were evaluated in BALB/c mice.ResultsERA005f was consistently expressed as an inclusion body in a prokaryotic expression system, and a highly pure form of the protein was successfully obtained. Both ERA005f and ERA005m significantly improved IgG titers in the serum. In addition, mice immunized with ERA005f and ERA005m generated higher titers of antigen-specific IgG2a than the other groups. Elispot results showed that, compared with other groups, ERA005f increased the numbers of IFN-γ-secreting and IL-4-secreting T cells, especially the number of IFN-γ-secreting T cells. Meanwhile, ERA005f induced a higher number of IFN-γ+ T lymphocytes than ERA005m did. In addition, ERA005f improved the expression of cytokines, including IFN-γ, IL-12p70, TNF-α, IL-17, and GM-CSF and so on. Importantly, both ERA005f and ERA005m significantly inhibited the growth of Mtb.ConclusionThe novel multistage antigen ERA005f elicited a strong antigen-specific humoral response and Th-1 and Th-17 cell-mediated immunity in mice. Meanwhile, it can effectively inhibit H37Rv growth in vitro, and represents a correlate of protection in vivo, indicating that ERA005f may exhibit excellent protective efficacy against Mycobacterium tuberculosis H37Rv infection. Our study suggests that ERA005f has the potential to be a promising multistage tuberculosis vaccine candidate.