bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Bioactive 1,2,3-Triazole-Fused Macrocycles via Azide-Alkyne Cycloaddition
Authors: Ansary Inul , Jahan Nasrin , Pal Arkadip 
Published: November 2023

AbstractA systematic highlight of syntheses reported since 2006 of 1,2,3-triazole-fused macrocycles possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory and antilarval action, is presented in this review. The well-renowned Cu-catalyzed azide-alkyne cycloaddition reaction was noted to be highly efficient and is one the most common methods utilized by scientists for the synthesis of 1,4-disubstituted triazole-fused macrocycles, whereas Ru-catalyzed cycloaddition is common for the formation of 1,5-disubstituted bioactive triazoles. This review would thus be extremely beneficial for both synthetic organic and medicinal chemists.1	Introduction2	Anticancer Derivatives3	Antibacterial Derivatives4	Derivatives with Dual Activity5	Antilarval Derivatives6	Anti-inflammatory Derivatives7	Antiviral Derivatives8	Anti-trypanosomal Derivatives9	Derivatives with Miscellaneous Activities10	Conclusion
Impact of Early Diagnostic and Therapeutic Interventions and Clinical
Course in Children and Adolescents with Multiple Endocrine Neoplasia Types 1 and
2
Authors: Kim Ja Hye , Lee Yena , Hwang Soojin , Yoon Ji-Hee , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho 
Published: November 2023

Abstract
Purpose Multiple endocrine neoplasia types 1 (MEN1) and 2 (MEN2) are
inherited endocrine tumor syndromes caused by mutations in the MEN1 or
RET genes. This study aimed to investigate clinical outcomes and
molecular characteristics among children with MEN.
Methods This study included eight patients from seven unrelated families.
Data on clinical course, biochemical findings, and radiologic studies were
collected by retrospective chart review. All diagnoses were genetically
confirmed by Sanger sequencing of MEN1 in three MEN1 patients and
RET in four patients with MEN2A and one patient with MEN2B.
Results Three patients with MEN1 from two families presented with
hypoglycemia at a mean age of 11±2.6 years. Four patients with MEN2A
were genetically diagnosed at a mean of 3.0±2.2 years of age by family
screening; one of them was prenatally diagnosed by chorionic villus sampling.
Three patients with MEN2A underwent prophylactic thyroidectomy from 5 to 6 years
of age, whereas one patient refused surgery. The patient with MEN2B presented
with a tongue neuroma and medullary thyroid carcinoma at 6 years of age.
Subsequently, he underwent a subtotal colectomy because of bowel perforation and
submucosal ganglioneuromatosis at 18 years of age.
Conclusion This study described the relatively long clinical course of
pediatric MEN with a mean follow-up duration of 7.5±3.8 years.
Insulinoma was the first manifestation in children with MEN1. Early diagnosis by
family screening during the asymptomatic period enabled early intervention. The
patient with MEN2B exhibited the most aggressive clinical course.
Navigating the Role of Anti-Obesity Agents Prior to Pregnancy: A Narrative Review
Authors: Goldberg Alyse S. , Dolatabadi Samin , Dutton Heidi , Benham Jamie L. 
Published: November 2023

AbstractUtilization of anti-obesity agents is rising in reproductive-age females with some planning for future pregnancy. Lifestyle-induced weight loss has been shown to increase spontaneous conception rate, improve rates of fertility intervention complications, and decrease pregnancy comorbidities. However, the definitive role of assisting weight loss with medication prior to pregnancy remains to be established. The implications of anti-obesity agent used prior to pregnancy are explored in this narrative review, considering benefits of weight loss as well as available evidence for use and risks of anti-obesity agents prior to pregnancy.
A bibliometric analysis of the use of the Gamification Octalysis Framework in training: evidence from Web of Science
Authors: Mohanty Sattwik , Christopher B Prabu 
Published: November 2023

AbstractThe Octalysis framework, which systematically organizes gamified elements in non-game settings, such as training, has become one of the most famous persuasive tools for changing user behaviour. The field of Gamification Octalysis Framework research is expanding rapidly, moving beyond elementary questions like “what” and “why” to more complex ones like “how” and “when”. However, there remain empirical and theoretical challenges such as demonstrating the effectiveness of the Gamification Octalysis Framework and codifying the principles underpinning effective gamification design. This paper uses bibliometric analysis and scientific mapping to characterize the structure and development of the academic field of the Gamification Octalysis Framework, with the help of intellectual, conceptual, and social network structures of the framework. Our findings provide insight into the field’s research frontiers and intellectual structures, the interconnections between articles, authors, and keywords, the current collaborative networks, the hottest themes, and the most cited authors, publications, and sources, for instance, that in recent years, the Gamification Octalysis Framework has attracted significant research attention in the training field. Interestingly, 66.6% of cutting-edge research is done in the social sciences, as compared to science and technology. Researchers, academicians and professionals should be made aware of Octalysis framework gamified method because it has been shown to increase user engagement and motivation outside of social sciences game setting. We recommend that countries outside Europe integrate the Gamification Octalysis Framework in training into their learning programs and launch corresponding research centres and journals.
Ice-and-snow tourism in China: trends and influencing factors
Authors: Yang Jianping , Wang Yanxia , Tang Fan , Guo Xinyu , Chen Hongju , Ding Guangxi 
Published: November 2023

AbstractIce-and-snow tourism (IST) is central to the Chinese ice-and-snow economy and can help achieve the green transformation and expansion of the Chinese economy. However, IST has not been defined conclusively in China. In this study, the IST concept was analyzed, and the growth of both tourism types was described using an Event–Time–Space comprehensive analysis method. Two temporal phases with large increases were highlighted in both tourisms. The factors promoting their increases were analyzed from market demand, the Beijing 2022 Olympics Winter Games, and scientific and technological developments for ice and snow. The 2020–2021 decrease in IST was primarily attributed to the COVID-19 pandemic. In addition, IST has dual challenges related to natural and socioeconomic factors. Climate warming has a long-term adverse effect on IST, particularly on glacier tourism. Traditional outdoor skiing tourism in Northeast China (NEC) may also be affected by more competition owing to increased ski tourism in the pan-Beijing-Tianjin-Hebei region, the Xinjiang Uygur Autonomous Region (XJUAR) and Southern China, as well as by the development of indoor skiing and ice/snow entertainment. These natural and socioeconomic factors currently limit the ability of IST to promote socioeconomic development in alpine areas, particularly in western China. However, there are many opportunities for future IST growth, including warmed comfort climate at high altitudes in the NEC, XJUAR and the Qinghai-Tibet Plateau, major glacier resource potentials, and IST development driven by policies. The findings of this study provide important information for decision-makers and investors in IST and its related industries.
Translation quality assessment practices of faculty members of colleges of languages and translation in Arab countries: an exploratory study
Authors: Abanomey Abdulaziz A. , Almossa Samar Yakoob 
Published: November 2023

AbstractThe investigation and understanding of the process of assessing translation quality in translation courses have attracted some attention. However, only a few studies have explored general assessment (GA) and specialised Translation Quality Assessment (TQA) practices used by different translation instructors. This study explores the assessment practices of 98 faculty members of the translation departments of various universities in Arab countries. In this exploratory study, data were collected using an adapted version of the Approaches to Classroom Assessment Inventory instrument. In addition, the authors designed a Translation Quality Assessment Practices Inventory aimed specifically for the investigation of TQA practices adopted by the faculty members. Data collected from the three-part survey were subjected to descriptive statistics, exploratory factor analysis, one-way analysis of variance, an independent samples t-test, and the chi-square test. The study reveals that the participants highly endorsed GA and TQA practices equally. The results indicate that three major TQA themes are particularly prioritised: the significance of errors; the use of particular assessment methods; and the primacy of objectivity. This research shows that there is an urgent need for more training aimed at improving TQA literacy among faculty members teaching translation courses. It contributes to the efforts to improve translation training and to design more effective curricula.
Analysis of plasma plume parameters in physio-chemical processes of RF plasma jet plume direct in water for the inactivation of Enterococcus bacteria
Authors: Morshedian N. , Mehramiz A. , Bakhshzadmahmoudi M. , Kharaghani M. , Mohammadhosseini B. , Badrli R. 
Published: November 2023

The contamination of Enterococcus bacterium is widely observed in the living environment and water. The decontamination of drinking water from the bacterial pollution is an important issue in water treatment. Here, the inactivation of Enterococcus bacteria is studied by placing the dielectric barrier discharge structure, with the RF discharge frequency of 13.56 MHz atmospheric pressure argon plasma jet, directly in water, whereas the water around the plasma plume was seething and the bubbles produced stirring all liquid volume. The ability to place a plasma jet nozzle directly in water for 10 min while maintaining a steady and uniform plasma plume, besides water temperature, provides the effectiveness enhancement in the inactivation of bacteria. The absorption of UV radiation in water is effective, and the role of UV radiation of plasma plume was mainly responsible for the destruction of peptidoglycan, which is the outer layer of Enterococcus. Then, the presence of electrons and plasma plume in water leads to the formation of hydroxyl, hydrogen peroxide, and other reactive radicals that are involved in chemical reactions, which lead to the inactivation of micro-organisms. The number of bacteria decreases from the initial value of 16 × 105 MPN/100 ml to less than 1.2 MPN/100 ml. The spectra of the plasma radiation, with the plume length 2 cm within the water, have been analyzed via the first nitrogen negative system N2+B−X. The plume temperature was calculated to be about 64 °C, which has a good agreement with water temperature measured by using a thermometer at about 67 °C after 15 min at maximum 200 W input power of the plasma jet.
One-to-two internal resonance in a micro-mechanical resonator with strong Duffing nonlinearity
Authors: Yu Jun , Donmez Ata , Herath Hansaja , Cho Hanna 
Published: November 2023

Abstract
This paper investigates the implementation of 1:2 internal resonance (InRes) in a clamped–clamped stepped beam resonator with a strong Duffing effect, focusing on its potential for frequency stabilization in micro-electro-mechanical systems (MEMS) resonators. InRes can arise in a nonlinear system of which mode frequencies are close to an integer ratio, facilitating the internal exchange of energy from an externally driven mode to an undriven mode. The presence of 1:2 InRes and Duffing hardening nonlinearity can result in frequency saturation phenomena, leading to a flat amplitude-frequency response range, which forms the basis for frequency stabilization. The stepped beam resonator design, combined with thermal frequency tuning, enables precise alteration of the frequency ratio between the second and third flexural modes required to achieve the desired 1:2 ratio for InRes. Experimental characterization and theoretical analysis revealed that frequency mismatch plays a significant role, with larger mismatch conditions leading to stronger energy exchange and a wider range of drive force for frequency saturation. The study highlights the frequency saturation mechanism utilizing 1:2 InRes and emphasizes the advantage of Duffing nonlinearity and larger intermodal frequency mismatch for broader frequency stabilization, providing valuable insights for the design and optimization of MEMS resonators.
Suppression of dielectric surface flashover induced by strong electromagnetic field at multiple spatial scales based on above/sub-surface discharge development mechanisms
Authors: Yang Xiong , Zhou Rundong , Song Baipeng , Sun Guangyu , Wang Chao , Zhao Xin , Zou Fangzheng , Lian Ruhui , Li Wenrui , Liu Haoyan , Li Wendong , Zhang Guanjun 
Published: November 2023

Abstract
Spacecraft charging and electrostatic discharging (ESD) are prone to occur in harsh space environments. In particular, in the case of coupling strong electromagnetic field (EMF), ESD damages may occur at a low charging potential, posing a serious threat to on-orbit spacecraft missions. To investigate the mechanism and the pertinent suppression method for vacuum surface discharge induced by EMF, a specially-designed platform for EMF-induced surface discharge was set up. Surface structures with various spatial scales were created separately by using different surface engineering strategies, including direct fluorination, mechanical polishing, and 3D-printed grooving. The resulting surface physicochemical characteristics of the samples were examined. Furthermore, the surface discharge characteristics for different methods induced by strong EMF were systematically analyzed, considering the surface trap state distribution and secondary electron yield (SEY). The findings indicate that the proposed surface treatment methods demonstrate varying levels of improvement in mitigating EMF-induced discharge. Direct fluorination was found to produce lower SEY and to accelerate surface charge dissipation due to an elevated shallow trap density, making it favorable for suppressing the EMF-induced discharge. In addition, suitable surface roughness and groove size can effectively impede the development of the multipactor, thereby preventing EMF-induced discharge. This research is expected to provide valuable insights into the protection design of EMF-induced discharge on spacecraft.
Magnetic field sensitivity of transition edge sensors
Authors: Harwin R C , Goldie D J , Thomas C N , Withington S 
Published: November 2023

Abstract
Understanding the magnetic field sensitivity of transition edge sensors (TESs) is vital in optimising the configuration of any magnetic shielding as well as the design of the TESs themselves. An experimental system has been developed to enable the investigation of the applied magnetic field direction on TES behaviour, and the first results from this system are presented. In addition, measurements of the effect of applied magnetic field magnitude on both supercurrent and bias current are presented. The extent to which the current theoretical framework can explain the results is assessed and finally, the impact of this work on the design of TESs and the design of magnetic shielding is discussed.
Simple quantification of elastomers’ deformation-induced entropy changes through maxwell relation implementation
Authors: Li Yuchen 
Published: November 2023

Abstract
An upper division experimental method to determine the configurational entropy change using an approximated Maxwell relation for short fiber reinforced polymers is presented. This approach mainly integrates two regression models in data analysis, respectively being the phenomenological Mooney-Rivlin model and the linear tension-temperature relation; the former simulates the tensile performance under various isothermal conditions, while the latter is used to measure the partial differential value

∂
S

∂
l

T

in the Maxwell relation. To further correct tensile data to accurately measure the minute configurational entropy change in loading, a linear-form segmented compensation function was used to correct the dynamic fatigue effect in repetitive tensile testing. With corrected Mooney-Rivlin fits under various temperature conditions graphed, one may focus on a fixed strain and investigate its corresponding linear tension-temperature relation to establish the numerical value of

∂
S

∂
l

T

.

In this way, the remaining unknown variable in the Maxwell relation is entropy, thereby enabling its mathematical determination. Such a simple experimental design serves as a convenient method to measure configurational entropy change with strain for basic research.
Performance evaluation of split high–K material based stacked hetero-dielectrics tunnel FET
Authors: Das Dipshika , Dhar Rudra Sankar , Ghosh Pradip Kumar 
Published: November 2023

Abstract
This research investigates the performance evaluation of a double gate TFET (DGTFET) by employing a hetero-dielectric gate structure featuring distinct high-K dielectrics with different work functions in a dual-material gate configuration. The gate dielectric stack is comprised of split high–K materials placed on the SiO2 dielectric. An outline of the analytical model for the validation of the novel device is developed and 2D simulations-based analysis and investigation are carried out. The impact of different high-K dielectric materials layered on top of silicon dioxide (SiO2) is examined; its effect on transfer characteristics, subthreshold swing (SS), minimum tunneling width, ratio of ON to OFF currents ION/IOFF, and energy band bending are investigated. The work functions optimization for the auxiliary and tunnel gates are made in this work to minimize OFF current, to reduce ambipolar phenomena and to enhance tunnel rate. The effects of gate potentials, source/ drain doping concentrations on the results are further studied. The threshold voltage of DGTFET is also modelled and computed for the proposed structures. The present findings revealed that the low OFF current (10−17 A μm−1) is provided by the proposed device structure, improved ratio of ION/IOFF (1011), and lowered subthreshold swing required for future era.
Exploring freeze-out and freeze-in dark matter via effective Froggatt-Nielsen theory
Authors: Mandal Rusa , Tong Tom 
Published: November 2023

Abstract
Motivated by the dynamical reasons for the hierarchical structure of the Yukawa sector of
the Standard Model (SM), we consider an extension of the SM with a complex scalar field, known as
`flavon', based on the Froggatt-Nielsen mechanism. In an effective theory approach, the SM fermion
masses and mixing patterns are generated in orders of the parameter related to the vacuum
expectation value of the flavon field and the cut-off of the effective theory. By introducing
right-handed neutrinos, we study the viability of the lightest right-handed neutrino as a dark
matter candidate, where the same flavon field acts as a mediator between the dark and the SM
sectors. We find that dark matter genesis is achieved both through freeze-out and freeze-in
mechanisms encompassing the 𝒪(GeV) – 𝒪(TeV) mass range of the mediator
and the dark matter particle. In addition to tree-level spin-dependent cross section, the model
gives rise to tree- and loop-level contributions to spin-independent scattering cross section at
the direct detection experiments such as XENON and LUX-ZEPLIN which can be probed in their future
upgrades. By choosing suitable Froggatt-Nielsen charges for the fermions, we also generate the
mass spectrum of the SM neutrinos via the Type-I seesaw mechanism. Flavor-changing neutral current
processes, such as radiative lepton decay, meson mixing, and top-quark decay remain the most
constraining channels and provide testability for this minimal setup that addresses several major
shortcomings of the SM.
Impact of interaction between RF waves and fast NBI ions on the fusion performance in JET DTE2 campaign
Authors: Kirov K.K. , Challis C.D. , De la Luna E. , Eriksson J. , Gallart D. , Garcia J. , Gorelenkova M. , Hobirk J. , Jacquet P. , Kappatou A. , Kazakov Y.O. , Keeling D. , King D. , Lerche E. , Maggi C. , Mailloux J. , Mantica P. , Mantsinen M. , Maslov M. , Menmuir S. , Siren P. , Stancar Z. , Van Eester D. ,   JET Contributors
Published: November 2023

Abstract
This work presents a study of the interaction between radio frequency (RF) waves used for ion cyclotron resonance heating and the fast deuterium (D) and tritium (T) neutral Beam injected (NBI) ions in DT plasma. The focus is on the effects of this interaction, also referred to as synergistic effects, on the fusion performance in the recent JET DTE2 campaign. Experimental data from dedicated pulses at 3.43 T/2.3 MA heated at (i) 51.4 MHz, giving the central minority H and n = 2 D, and at (ii) 32.2 MHz for the central minority 3He and n = 2 T. Resonances are analysed and conclusions are drawn and supported by modelling of the synergistic effects. Modelling with transport code TRANSP runs with and without the RF kick operator predict a moderate increase, of about 10%, in DT rates for the case of the RF wave—fast D NBI ion interactions at the n = 2 harmonic of ion cyclotron resonance, and a negligible impact due to synergistic interaction between fast T NBI ions and RF waves. JETTO modelling gives a 29% enhancement in fusion rates due to the interction between RF waves and fast D NBI ions, and an 18% enhancement in fast T NBI ions. Analysis of experimental neutron rates compared to TRANSP predictions without synergistic effects and magnetic proton recoil neutron spectrometer indicate an enhancement of approximately 25%–28% in fusion rates due to RF interaction with fast D ions, and an enhancement of approximately 5%–8% when RF waves and fast T NBI ions are interacting. The contributions of various heating and fast ion sources are assessed and discussed.
Solving Flexible Shop Scheduling Problems Based on Improved NSGA-II
Authors: Lan Xueqi , Zhang Jianxin 
Published: November 2023

Abstract
This paper proposes an improved non-dominated sorting genetic algorithm-II (NSGA-II) by incorporating local search techniques to address the issues of slow convergence speed and susceptibility to local optima in traditional NSGA. Multiple local search techniques are combined with NSGA-II to enhance the convergence speed and solution quality. In each generation, the algorithm selects key operations on the critical path for local search and applies the principles of minimizing costs and minimizing energy consumption to guide the local search on individuals. The optimization goals consist of reducing the longest completion time, minimizing expenses, and lowering energy usage. Experimental results on multiple instances of flexible job shop scheduling problems demonstrate that this algorithm exhibits good performance and effectiveness.