bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Computed Tomography Angiography for capturing vessel wall motion: A phantom study for optimal image reconstruction
Authors: Stam Lotte B. , Linden Sabine M. L. , Oostveen Luuk J. , Hansen Hendrik H. G. , Aquarius René , Slump Cornelis H. , de Korte Chris L. , Bartels Ronald H. M. A. , Prokop Mathias , Boogaarts Hieronymus D. , Meijer Frederick J. A. 
Published: December 2023

Background
Reliably capturing sub-millimeter vessel wall motion over time, using dynamic Computed Tomography Angiography (4D CTA), might provide insight in biomechanical properties of these vessels. This may improve diagnosis, prognosis, and treatment decision making in vascular pathologies.

Purpose
The aim of this study is to determine the most suitable image reconstruction method for 4D CTA to accurately assess harmonic diameter changes of vessels.

Methods
An elastic tube (inner diameter 6 mm, wall thickness 2 mm) was exposed to sinusoidal pressure waves with a frequency of 70 beats-per-minute. Five flow amplitudes were set, resulting in increasing sinusoidal diameter changes of the elastic tube, measured during three simulated pulsation cycles, using ECG-gated 4D CTA on a 320-detector row CT system. Tomographic images were reconstructed using one of the following three reconstruction methods: hybrid iterative (Hybrid-IR), model-based iterative (MBIR) and deep-learning based (DLR) reconstruction. The three reconstruction methods where based on 180 degrees (half reconstruction mode) and 360 degrees (full reconstruction mode) raw data. The diameter change, captured by 4D CTA, was computed based on image registration. As a reference metric for diameter change measurement, a 9 MHz linear ultrasound transducer was used. The sum of relative absolute differences (SRAD) between the ultrasound and 4D CTA measurements was calculated for each reconstruction method. The standard deviation was computed across the three pulsation cycles.

Results
MBIR and DLR resulted in a decreased SRAD and standard deviation compared to Hybrid-IR. Full reconstruction mode resulted in a decreased SRAD and standard deviations, compared to half reconstruction mode.

Conclusions
4D CTA can capture a diameter change pattern comparable to the pattern captured by US. DLR and MBIR algorithms show more accurate results than Hybrid-IR. Reconstruction with DLR is >3 times faster, compared to reconstruction with MBIR. Full reconstruction mode is more accurate than half reconstruction mode.
Impact of perceived discrimination and coping strategies on well-being and mental health in newly-arrived migrants in Spain
Authors: Gabarrell-Pascuet Aina , Lloret-Pineda Amanda , Franch-Roca Marta , Mellor-Marsa Blanca , Alos-Belenguer Maria del Carmen , He Yuelu , Hafi-Elmokhtari Rachid El , Villalobos Felipe , Bayes-Marin Ivet , Aparicio Pareja Lola , Álvarez Bobo Oscar , Espinal Cabezas Mercedes , Osorio Yolanda , Haro Josep Maria , Cristóbal-Narvaez Paula 
Published: December 2023

Objectives
To explore how perceived discrimination impacts the emotional well-being and mental health of newly-arrived migrants in Spain; and to identify the coping strategies and behavioral changes used to deal with perceived discrimination.

Design
102 individual audio-recorded in-depth qualitative interviews were conducted. The interviews were transcribed and analyzed through content analysis.

Results
Negative emotions related to perceived discrimination included disgust, sadness, fear, loneliness, humiliation, sense of injustice, rage, feeling undervalued or vulnerable, and mixed emotions. Change in behaviors due to perceived discrimination comprised westernization or cultural assimilation, creating a good image, avoiding going out or leaving alone, hypervigilance, stop participating in politics, self-sufficiency, a positive adaptation, and paradoxically, becoming an oppressor. The identified coping strategies to deal with perceived discrimination were ignoring or not responding, isolation, self-medication, engagement in intellectual activities, leisure and sport, talking or insulting the oppressor, denouncement, physical fight or revenge, seeking comfort, increasing solidarity with others, crying, or using humor. Discrimination-related stress and related mental health problems were conveyed, as challenges related to substance abuse and addictive behaviors, mood, and anxiety.

Conclusions
Findings establish initial evidence of the great impact of perceived discrimination on the health, emotional well-being, and behavior of newly-arrived migrants in Spain, alerting to the need for targeted policies and services to address the effects of discrimination in this population. Further research is needed to explore more closely the causes and effects of perceived discrimination on mental health, to develop more targeted and effective interventions.
Vericiguat protects against cardiac damage in a pig model of ischemia/reperfusion
Authors: Zhu Weida , Ben Yue , Shen Yang , Liu Wenbing 
Published: December 2023

Background
The purpose of this research was to verify that vericiguat, a soluble guanylate cyclase (sGC) stimulator, reduces myocardial ischemic reperfusion injury (MIRI), and to learn how this reduction happens.

Methods and results
To develop an ischaemia/reperfusion (I/R) model, the left anterior descending artery was blocked in minipigs under anesthesia for 90 minutes, followed by 180 minutes of reperfusion. Vericiguat is administered three hours before surgery. Two weeks after receiving therapy, pigs underwent cardiovascular magnetic resonance imaging (MRI) to evaluate the results. The MRI results suggest improvement in the myocardial infarct after vericiguat treatment. Vericiguat treatment for two weeks enhanced vascularity, inhibited pro-inflammatory cells, and decreased collagen deposition in the infarct zone of pigs. Short-term experiments investigating possible explanations have indicated that vericiguat has antiapoptotic effects on cardiomyocytes and increases levels of autophagy.

Conclusions
Vericiguat, an SGC activator, reduces MIRI in pigs by boosting autophagy, preventing apoptosis, and promoting angiogenesis.
Entornos Virtuales de Aprendizaje y Desarrollo en el Instituto de Educación Superior 9–029
Authors: Bustos Adriana Valeria , Merciel José Francisco , Gallardo Guillermo 
Published: December 2023

En la época contemporánea, se manifiestan una gran gama de transformaciones sociales y culturales que constituyen un nuevo escenario —complejo— para la educación. Por lo tanto, se considera que la educación enfrenta el desafío de incluir a todos los niños/as, jóvenes y adultos/as, de garantizar puntos de partida y de llegada, desde un enfoque de protección y promoción de derechos.
Asimismo, las Tecnologías de la Información y de la Comunicación (TIC), impactan en las maneras de conocer, relacionarse, comunicar/se y producir conocimiento. En síntesis, con ello, y desde un enfoque relacional con la tecnología, podemos expresar que existe una simbiosis —personas/tecnologías— ya que las personas se modifican con la tecnología y ellas modifican a la tecnología también. Asimismo, Burbules y Callister (2006) manifiestan que «existe una ambivalencia y mutua influencia entre persona y tecnología», es decir, hay una línea difusa entre lo humano y lo tecnológico ya que «somos tecnología».
En el presente trabajo se muestran las prácticas realizadas por el Instituto de Educación Superior 9–029 para fomentar la inclusión de las TIC en el ámbito educativo, desde una postura relacional con la tecnología, a partir del análisis realizado mediante las matrices FODA y Matriz TIC de Lugo y Kelly.
Portrait of a patient with systemic lupus erythematosus for the prescription of the type I interferon inhibitor anifrolumab
Authors: Reshetnyak T. M. , Aseeva E. A. , Shumilova A. A. , Nikishina N. Yu. , Shkireeva S. Yu. , Lila A. M. 
Published: December 2023

In recent years the use of monoclonal antibodies that block activity of type I interferon (IFN) or its receptors has become the new approach in the pharmacotherapy of systemic lupus erythematosus (SLE).Objective: to characterize patients with SLE treated with the type I IFN receptor inhibitor anifrolumab (AFM, Saphnelo®).Material and methods. The prospective 12-month study included 21 patients with SLE who met the 2012 SLICC criteria. Standard laboratory and immunological markers for SLE were examined in all patients. The SLEDAI-2K index was used to determine the activity of SLE and the CLASI index was used to determine the severity of the mucocutaneous syndrome. Organ damage was assessed using the SLICC/ACR Damage Index (DI). The LupusQol and FACIT-Fatigue questionnaires were used to analyze health-related quality of life (HRQoL).Results and discussion. Female patients prevailed in the study, female/male ratio – 17 (81%)/4 (19%), median age – 31 [27; 46] years, disease duration – 9 [6.0; 11.0] years. The majority of patients (86%) had moderate or high disease activity according to the SLEDAI-2K index. Among the clinical manifestations of SLE, skin and mucous membranes lesions predominated (81%). Non-erosive polyarthritis of varying severity was observed in 66% of cases. Serositis showed 24% of patients (pleurisy, pericarditis), 43% had hematological abnormalities (hemolytic anemia, leukopenia, lymphopenia) and 14% - urinary syndrome (daily proteinuria up to 0.5 g/l and/or urinary sediment – leukocytes/erythrocytes/cylinders up to 5 in the field of view in the absence of urinary tract infection). All patients had immunological disorders. 14% of them were diagnosed with antiphospholipid syndrome (APS) and 43% with Sjögren's syndrome.All patients received hydroxychloroquine, 95% received glucocorticoids (GC) from 5 to 60 mg/day, 66% received immunosuppressants (cyclophosphamide, mycophenolate mofetil, azathioprine, methotrexate). 33% of patients had anamnesis of treatment with biologic disease modifying antirheumatic drugs (rituximab, belimumab, dual anti-B-cell therapy) and Janus kinase inhibitor baricitinib. All patients experienced a significant deterioration in HRQoL.Conclusion. The indications for prescribing AFM to 21 patients with SLE were: active SLE according to SLEDAI-2K and/or CLASI with predominant involvement of skin, its appendages and development of polyarthritis with immunological disorders, intolerance/ineffectiveness of previous standard therapy and inability to achieve low average daily doses of oral GCs. Other clinical manifestations in some patients were: serositis, mild hematological disorders (Coombs-positive anemia, leukopenia), urinary syndrome. AFM could be prescribed for a combination of SLE with secondary APS and Sjögren's syndrome as well as for a high DI SLICC.
Efficacy and safety of the Gam-COVID-Vac in patients with immunoinflammatory rheumatic diseases: preliminary data of prospective study
Authors: Kulikov A. N. , Muravyeva N. V. , Belov B. S. , Gridneva G. I. , Aronova E. S. 
Published: December 2023

Objective: to study the efficacy and safety of the Gam-COVID-Vac vaccine in patients with immunoinflammatory rheumatic diseases (IRD) in a prospective study.Material and methods. The study included 42 patients with IRD and 57 individuals without IRD (control group) who received at least one component of Gam-COVID-Vac. Immunization with the first component of the vaccine was carried out from March 25th to August 1st, 2022, the second – 3 weeks after the first dose. On days 1, 3 and 7 after administration of the first and second components, the study participants provided information on adverse events (AEs) by telephone. All subjects were examined by a rheumatologist 1, 3 and 6 months after complete immunization. The observation period after immunization with the second dose was 6 months.Results and discussion. 42 patients received the first component of the vaccine, and 39 patients received two components. In the control group, 57 subjects were immunized with two components of the vaccine. 30–180 days after vaccination with two components of Gam-COVID-Vac, 3 (7.7%) patients were diagnosed with SARS-CoV-2 infection, which was confirmed by polymerase chain reaction. In all cases, a mild course of COVID-19 without signs of pneumonia was observed. There were no cases of COVID-19 in the control group. After immunization with the first component, a combination of at least one local and one systemic AE (SAE) was documented in 28.6% of patients with IRD and 33.3% of individuals in the control group (p>0.05). No AEs were recorded in 42.9% and 36.8% of cases respectively (p>0.05). After vaccination with the second component, a combination of ≥1 local AE and SAE was recorded in 15.4 % of patients with IRD and 22.8% of individuals in the control group (p>0.05). No AEs occurred in 71.8% and 56.1% of cases respectively (p>0.05). In 10.3% of patients with IRD and 12.3 % of those without IRD (p>0.05), a combination of local and systemic AEs was recorded after the introduction of both first and second components. No AEs were observed in 35.9% and 28.1% of cases, respectively (p>0.05). The overall rate of IRD exacerbations was 4.8%.Conclusion. Based on the available data, vaccination against COVID-19 appears to be effective and quite safe in patients with IRD.
Zweckzuweisungen für kommunale Investitionen – ein Instrument räumlicher Steuerung?
Authors: Hotz Dieter 
Published: December 2023

Zweckzuweisungen für kommunale Investitionen gehören zu den Politikbereichen, in denen vielfältige Aufgaben der vertikalen und horizontalen Koordination bestehen. Nach einer theoretischen Herleitung des Zusammenhangs von Raumordnung und Zweckzuweisungen für kommunale Investitionen wird dargelegt, daß die räumliche Vollzugskontrolle der Zuweisungsvergabe noch in den Anfängen steht.Daran anschließend werden die Ergebnisse einer Fallstudie über das Investitions- und Finanzierungsverhalten einer Mittelstadt Nordrhein-Westfalens vorgestellt. In dieser Untersuchung – vgl. Forschungen zur Raumentwicklung der Bundesforschungsanstalt für Landeskunde und Raumordnung, Band 16, Bonn 1987 – werden die Wirkungen von Zweckzuweisungen en detail anhand abgeschlossener Investitionsvorhaben – u. a. aus den Bereichen Schulbau, Sportstättenbau, Verkehrswegebau, Feuerwehrgebäude und Wanderwegebau – dargestellt.Abschließend werden Reformmöglichkeiten der Zweckzuweisungsvergabe diskutiert und ein Ausblick gegeben.
Peningkatan Karakteristik Biokomposit Pektin Kulit Jeruk dan TiO2
Authors: Silvia Deli , Annisa Siti Nur 
Published: December 2023

Indonesia menghasilkan sekitar 7,8 juta ton sampah plastik setiap tahunnya. Hampir 83% sampah tersebut berasal dari daratan dan lautan, sisanya 17% berasal dari wilayah pesisir. Limbah ini mengakibatkan terjadinya pencemaran tanah, air, laut bahkan udara terhadap organisme dan lingkungan. Sehingga perlu adanya alternative dalam penggunaan kemasan, salah satunya dengan penggunaan biokomposit. Kemasan yang bersifat compostable dan biodegradable dengan menggunakan bahan alami. Telah dilakukan penelitian pembuatan biokomposit dari pati porang, pektin kulit jeruk, sorbitol dengan penambahan variasi TiO2 (b/v) (0%, 0,3%, 0,5% dan 0,7%). Tujuan penelitian ini untuk menganalisis sifat karakteristik biokomposit sesuai Standar Nasional Indonesia (SNI). Dengan melakukan pengujian karakteristik biokomposit berupa uji ketebalan, uji kuat tarik, uji elongasi, dan uji elastisitas. Nilai tertinggi pengujian karakteristik biokomposit diperoleh pada konsentrasi 0,7% dengan nilai ketebalan 0,182 mm; kuat tarik 8,473 MPa; elongasi 64,05% dan elastisitas 0,0185 MPa. Hasil yang diperoleh telah dibandingkan dengan nilai SNI, dan telah memenuhi SNI 7188.7:2016 sebagai kantong belanja. Indonesia produces around 7.8 million tons of plastic waste every year. Almost 83% of this waste comes from land and sea, with the remaining 17% coming from coastal areas. This waste causes pollution of soil, water, sea and even air to organisms and the environment. So there needs to be an alternative in the use of packaging, one of which is the use of biocomposites. Packaging that is compostable and biodegradable using natural materials. Research has been conducted on the manufacture of biocomposites from porang starch, orange peel pectin, sorbitol with the addition of TiO2 variations (b/v) (0%, 0.3%, 0.5% and 0.7%). The purpose of this study was to analyze the characteristics of biocomposites according to the Indonesian National Standard (SNI). By testing the characteristics of biocomposites in the form of thickness test, tensile strength test, elongation test, and elasticity test. The highest value of biocomposite characteristics testing was obtained at a concentration of 0.7% with a thickness value of 0.182 mm; tensile strength of 8.473 MPa; elongation of 64.05% and elasticity of 0.0185 MPa. The results obtained have been compared with SNI values, and have met SNI 7188.7: 2016 as a shopping bag.
The effects of high‐intensity exercise training and detraining with and without active recovery on postexercise hypotension in young men
Authors: Lei Tze‐Huan , Fujii Naoto , Zhang Xiao , Wang Faming , Mündel Toby , Wang I‐Lin , Chen Yi‐Ming , Nishiyasu Takeshi , Amano Tatsuro , Dobashi Kohei , Wang Lin , Yeh Tzu‐Shao , Kondo Narihiko , Goulding Richie P. 
Published: December 2023

AbstractWhether high‐intensity exercise training and detraining combined with skeletal muscle pump (MP) could alter the magnitude of postexercise hypotension has not been investigated. We therefore sought to determine whether the combination of MP (unloaded back‐pedaling) with 4 weeks of high‐intensity exercise training and detraining could alter the magnitude of postexercise hypotension. Fourteen healthy men underwent 4 weeks of high‐intensity exercise training (5 consecutive days per week for 15 min per session at 40% of the difference between the gas exchange threshold and maximal oxygen uptake [i.e., Δ40%]) followed by detraining for 4 weeks. Assessments were conducted at Pre‐training (Pre), Post‐training (Post) and after Detraining with (MP) and without MP (Con). The exercise test in the Pre, Post and the Detraining consisted of 15 min exercise at Δ40% followed by 1 h of recovery. At all time‐points, the postexercise reduction in mean arterial pressure (MAP) was reduced in MP compared to Con (all p < 0.01). Four weeks of high‐intensity exercise training resulted in a reduction in the magnitude of postexercise hypotension (i.e., the change in MAP from baseline was mitigated) across both trials (All p < 0.01) when compared to Pre and Detraining. Following Detraining, the reduction of MAP from baseline was reduced compared to Pre, but was not different from Post. We conclude that high‐intensity exercise training combined with skeletal MP reduces the magnitude of postexercise hypotension, and this effect is partially retained for 4 weeks following the complete cessation of high‐intensity exercise training.
Investigation of the effects of water uptake on the mechanical properties of wood dust particle filled Prosopis Juliflora reinforced phenol formaldehyde hybrid polymer composites
Authors: Brindha Ganesan , Arul Sujin Jose , Lenin A. Haiter , Premila Jani Stanly Kochappa 
Published: December 2023

Abstract
The water uptake behavior of Wood Dust (WD)/Prosopis Juliflora Fiber (PJF)/Phenol-Formaldehyde (PF) hybrid composites which are immersed in distilled and seawater environments was evaluated. Three different composite samples were fabricated by reinforcing WD and PJF with PF resin. The fabricated specimens were immersed in sea and distilled water to note down the moisture content absorption of the specimens for different time intervals from 0 to 240 h. The dry and wet specimens underwent mechanical properties testing as per ASTM standards and the findings for wet and dry specimens have been compared and analyzed. It is observed that the specimens which are immersed in sea (salt) water absorb more moisture content than the specimen immersed in distilled water and the PJF-rich (30 wt% of PJF & 10 wt % of WD) specimen absorbs more water than the other specimens. The water uptake behavior of the WD/PJF/PF hybrid composite follows a non-Fickian behavior. The mechanical performance (tensile, flexural, and impact) of the 10 wt % of WD 30 wt % of PJF specimen was better than that of other specimens at dry (before immersion) conditions and lost strength when immersed in sea and distilled water. SEM analysis was also done on the broken surface of the tested specimens which were exposed to the water environment.
Preparation of water-based dextran-coated Fe3O4 magnetic fluid for magnetic hyperthermia
Authors: Li Hongcai , Wu Qian , Yuan Xiaofei , Li Yonggang , Xu Ying , Hong Ruoyu 
Published: December 2023

Abstract
Fe3O4 nanoparticles were prepared by chemical co-precipitation, modified with dextran, and dispersed in water to form a magnetic fluid (MF) for use in biomedical areas. The analyses of stability and magnetic property demonstrate that the prepared functional MF possesses outstanding stability (stability index within 60 days, high dilution stability, and autoclaved stability) and high magnetization (the values χ and M

s
of MF are 5.87 × 10−4 and 20.57 emu/g, respectively). Due to the coating of dextran, the toxicity of MF is minimal (in vitro survival rate of MCF-7 cells, blood compatibility, and in vivo toxicity). In addition, although the outer layer is coated with dextran, the M

s
intensity remains high, so the Fe3O4 MF owns a fast magnetic temperature response (when the MF concentration is 55 mg/mL, it can rapidly rise to 55°C within 800 s), which plays an extremely vital role in MF hyperthermia. So, the MF can effectively cause necrosis of human lung A549 cells, which shows a certain application potential.
Mechanical properties of seawater volcanic scoria aggregate concrete-filled circular GFRP and stainless steel tubes under axial compression
Authors: Nie Ruifeng , Huang Yijie , Wang Siwei , Zhang Fengxue , Wang Qing , Zhang Yukun 
Published: December 2023

Abstract
In this study, the properties of seawater volcanic scoria aggregate concrete (SVAC)-filled circular stainless steel (SFCST) and glass fibre-reinforced plastic (GFRP) tubes (SFCGT) were investigated. Ten groups were considered and 30 specimens were prepared, including four different parameters: the concrete type (SVAC and ordinary concrete [OC]), outer tube type (GFRP and stainless steel tubes), concrete strength (C30 and C40), and tube thickness (0, 3, and 4 mm). The typical influences of the SVAC and outer tube on the mechanical properties of specimens were then analysed. The research findings show that the strength and ductility of the SFCGT and SFCST are significantly higher than those of plain SVAC. The peak strain and strength enhancement factor of the SFCGT and SFCST increase with an increase in the tube thickness, and the concrete strength has a detrimental impact on the toughness of the specimen. Unlike in the confined OC specimens, a sudden decrease is observed in the stress–strain curves of the SFCGT and SFCST owing to the changes in the deformability of the SVAC. Generally, the strengths of the SFCGT and SFCST specimens are 10.3% lower and 4.1% higher than those of the confined OC specimens, respectively. Finally, analytical models of the strength and stress–strain curves considering the influences of the SVAC and passive confinement were established, and numerical simulations were performed to provide a basis for the practical application of the SFCGT and SFCST.