bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity, reliability, and invariance across sex of a German version of the Behavioral Regulation in Exercise Questionnaire
Authors: Cocca Armando , Kopp Martin , Greier Klaus , Labek Karin , Cocca Michaela , Ruedl Gerhard 
Published: February 2024

ObjectiveSince there is no scientifically validated German version of the Behavioral Regulation in Exercise Questionnaire (BREQ-3), the aim of this study was to assess its psychometric parameters and invariance across sex in a sample of German-speaking young adults. The BREQ-3 is an instrument measuring the social and internal influences of motivation toward exercising. This tool is widespread within the scientific community and has been validated in several languages.MethodsA total of 271 participants (45% women; mean age = 20.67 ± 2.17 years; effect size ≥ 0.5) filled in the BREQ-3 at one time point, with a small sub-sample (n = 37) responding it a second time after 15 days. Confirmatory Factorial Analysis, Structural Modeling, and Intraclass Correlation Coefficient were used to examine the German version of the questionnaire.ResultsResults highlighted a good fit of the six-dimensional model after the removal of two items (CFI = 0.912; SRMR = 0.0594; RMSEA = 0.064), as well as full invariance across sex (pχ2 = 0.218; ΔCFI &lt; 0.01). Internal consistency and reliability were moderate to good.ConclusionsThe 22-item German BREQ-3 is a scientifically valid instrument that can be used in cross-national studies dealing with social aspects of exercise behaviors.
Genetic polymorphism in HTR2A rs6313 is associated with internet addiction disorder
Authors: Dai Yu , Zhang Chenchen , Zhang Lingrui , Wen Chao , Li Hongya , Zhu Tianmin 
Published: February 2024

IntroductionInternet addiction disorder (IAD) has grown into public health concern of global proportions. Previous studies have indicated that individuals with IAD may exhibit altered levels of serotonin and dopamine, which are known to play crucial roles in depression, anxiety, impulsivity, and addiction. Therefore, polymorphisms in the receptors that mediate the effects of serotonin and dopamine and affect their functional states as well as their activities are suspect. In this study, we aimed to investigate the association between IAD and rs6313 (T102C) polymorphism in the serotonin 2A receptor (5-HT2A) gene, (HTR2A).MethodsTwenty patients with IAD and twenty healthy controls (HCs) were included in this study. Young’s Internet Addiction Test (IAT), Self-Rating Anxiety Scale, Self-Rating Depression Scale, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Barratt Impulse Scale, Pittsburgh Sleep Quality Index (PSQI), and Social Support Rating Scale (SSRS) were used to assess the severity of internet addiction, mental status, impulsive traits, sleep quality, and social support. Genotyping was performed to identify rs6313 polymorphisms in the HTR2A gene of all participants.ResultsThe frequencies of the C and T alleles of HTR2A T102C were 28% and 72% in the IAD group and 53% and 47% in the HCs group, respectively, indicating that the differences between these two groups were significant. No significant difference was observed in the distribution of the CC, CT, and TT genotypes of HTR2A gene T102C between the IAD and the HCs groups. Additionally, there was no difference in the distribution of the frequencies of the HTR2A gene T102C CC and CT+TT genotypes between the two groups. However, the distribution between the TT and CC+CT genotypes showed an apparent statistical difference in the HTR2A gene T102C between the two groups. Correlation analysis indicated that the IAT score was positively correlated with the Y-BOCS and BIS scores for the CC+CT genotype in patients with IAD. Moreover, the IAT score was positively correlated with the PSQI score in patients with IAD carrying the TT genotype.ConclusionThe present study demonstrates that rs6313 in HTR2A is associated with IAD, and that the T allele of rs6313 in HTR2A may be a risk factor for IAD.
A qualitative analysis of the documentation of DSM-5 Cultural Formulation Interviews with non-native speaking patients in a Swedish mental health care setting
Authors: Wallin Malin Idar , DeMarinis Valerie , Nevonen Lauri , Bäärnhielm Sofie 
Published: February 2024

IntroductionCultural variety in expressed symptom presentations of mental health problems creates difficulties in transcultural diagnostic assessments. This emphasizes the need of culturally sensitive diagnostic tools like the Cultural Formulation Interview (CFI). Although the CFI is being implemented worldwide there is a lack of studies analyzing what kind of information it provides when used with new patients in routine psychiatric assessments, and how CFI information contributes to diagnostic evaluations. This study aimed to find out what information the CFI questions revealed when used with non-native Swedish speaking patients. We also wanted to understand how the CFI may facilitate identification of psychiatric diagnoses among these patients.Materials and methodsThe CFI was used as part of a routine clinical psychiatric assessment in an outpatient clinic in Sweden. Interpreters were used in the consultations when needed. A qualitative thematic analysis was used to analyze the documented CFI answers from non-native speaking patients.ResultsWe found that the CFI information contained contextualized descriptions of dysfunction and current life conditions, as well as expressions of emotions, often described along with somatic terms.DiscussionOur results indicate that the narrative approach of the CFI, giving contextualized information about distress and functioning, can facilitate clinicians’ identification of psychiatric symptoms when language, psychiatric terms and understandings are not shared between patient and clinician.
Shortcomings of services for persons with severe and persistent mental health challenges: a qualitative study of service users and family carers
Authors: Isaacs Anton , Lambert Caroline , Lawn Sharon , Dyer Anna 
Published: February 2024

IntroductionThe opinions of service users and carers are crucial to identifying ways to innovate and implement system change. This study aims to explore the views and experiences of service users and carerson the services they have used for their mental health challenges and their suggestions for service reform.MethodsTwenty participants (15 carers and 5 service users) were interviewed for the study.ResultsEight categories emerged from the data. They were: Several gaps in the system, Barriers to accessing services, Services are not fit for purpose, Services operate in isolation, System is not person focused, Service users and carers are treated poorly, Services are overloaded and under resourced and Recommendations for service reform. Respondents reported that a persistent lack of funding and resources for mental health services was a main cause of these shortcomings. Respondents also noted that innovations were needed to re-orient services to enable continuity of care, and training of mental health professionals was needed for a better understanding of the needs of service users and their carers.DiscussionAdditional research is needed with larger and more diverse samples to further explore these findings.
Effects of active video games on physical activity among overweight and obese college students: a systematic review
Authors: Zhao Yue , Soh Kim Geok , Saad Hazizi Abu , Liu Chunqing , Ding Cong 
Published: February 2024

BackgroundThe purpose of this study was to critically review the existing literature on the effects of active video games (AVGs) on physical activity in overweight and obese college students to determine whether AVGs can promote and achieve recommended levels of physical activity. The results should provide constructive input for future research.MethodsA total of five international databases including PubMed, SCOPUS, Web of Science, CINAHL Plus, and EBSCOhost were searched with keywords related to “active video games,” “physical activity,” and “obese college students” from July 2022. A systematic review was conducted using the PRISMA guidelines and randomised controlled trial (RCT) studies that met the inclusion criteria were included. Furthermore, the quality assessment of the studies was measured using the PEDro scale.ResultsOne thousand and twenty-three articles were retrieved, of which eight randomised controlled trial studies met the inclusion criteria. AVGs can reduce sedentary behaviour and positively affect physical activity, time spent on moderate-to-vigorous physical activity (MVPA), positive psychological factors, and game attendance rate. Combining AVGs with other assistive devices (such as mini-trampolines and stationary bikes) can enhance the effects of AVGs and provide greater physiological stimulation. Different types of AVGs and game modes can achieve different emotional responses, physiological stimulation, and physical activity levels.ConclusionThe research findings prove that AVGs can be a viable intervention to increase physical activity in overweight or obese college students, ultimately reaching the recommended physical activity level(PAL). Physical activity can be further increased by incorporating assistive devices or using features supported by self-determination theory (SDT). As a new modality, AVGs could be a potential alternative to traditional physical activity.Systematic Review Registration:https://www.crd.york.ac.uk/prospero, identifier: CRD42022363993.
Alarming patterns of moderate and high-risk alcohol use among transgender women in Goiás, Central Brazil
Authors: Magalhães Larissa Silva , dos Santos Kamila Cardoso , Diniz e Silva Bruno Vinícius , Filho Gabriel Francisco Silva , Vaddiparti Krishna , Gonzalez Roxana Isabel Cardozo , Pillon Sandra Cristina , Carneiro Megmar Aparecida dos Santos , Caetano Karlla Antonieta Amorim , Cook Robert Lewis , Teles Sheila Araújo 
Published: February 2024

BackgroundScant studies have examined alcohol consumption among transgender women in Latin America. This cross-sectional study estimated the prevalence and associated factors of risky alcohol use among transgender women in Goiás, a state located in the center of Brazil.MethodsParticipants were 440 transgender women (median age = 35 years, interquartile range = 9) recruited through respondent-driven sampling. All participants were interviewed about sociodemographic characteristics, violence, and risk behavior. Alcohol use was assessed using the alcohol use disorders identification test (AUDIT). An AUDIT score greater than or equal to eight was considered as risky alcohol consumption. Logistic regression analysis was used to examine predictors of risky alcohol use, and p-values &lt;0.05 were considered significant.ResultsThe majority were young, single, sex workers. Most transgender women had used alcohol in the previous year (85.7%), and more than half (56.6%) reported binge drinking and risky alcohol consumption (60.2%). There was a high overlap between sexual behavior, drugs, and alcohol use. Using alcohol during sex (adjusted odds ratio [aOR]: 2.9; 95% confidence interval [CI]: 1.7–4.8), cocaine/crack use (aOR: 2.3; 95% CI: 1.5–3.7) and having a drug user as a sexual partner (aOR: 2.9; 95% CI: 1.5–5.9) were independently associated with risky alcohol consumption.ConclusionAlcohol consumption was highly prevalent, and drugs seem to play an important role in risky alcohol consumption among transgender women Goiás. These findings support stakeholders to promote intervention strategies to reduce this pattern of alcohol consumption and reduce the burden of substance use disorders among transgender women.
Sex differentials in the prevalence of behavioral risk factors and non-communicable diseases in adult populations of West Kazakhstan
Authors: Baspakova Akmaral , Abitova Anara Zh. , Mussin Nadiar M. , Kaliyev Asset A. , Yerimbetova Gulmira , Zhumagaliyeva Saltanat , Ashimova Zhanat , Zhilisbayeva Kulyash R. , Umbetova Aigerim A. , Nurtazina Alma U. , Tamadon Amin 
Published: February 2024

IntroductionThe prevalence of non-communicable diseases (NCDs) is increasing worldwide. Several modifiable risk factors, such as smoking, alcohol drinking, physical inactivity, and obesity, have been linked to the development of NCDs in both genders. Understanding the prevalence of these risk factors and their associated factors is crucial for effective intervention planning in adult populations. This study aimed to provide an overview of the prevalence and associated factors of these risk behaviors among different genders of adults in West Kazakhstan.MethodsA cross-sectional study was conducted in four regions of West Kazakhstan. A stratified multistage sampling technique was utilized to obtain a representative sample size of 4,800 participants aged 18 -69 years. Trained researchers administered face-to-face interviews using validated questionnaires to gather information pertaining to sociodemographic characteristics, smoking habits, alcohol drinking, dietary patterns, physical activity levels, body mass index (BMI), and prevalent diseases.ResultsThis study, which included 4,800 participants from West Kazakhstan, revealed some striking numerical findings. The overall prevalence rates of behavioral risk factors and metabolic conditions were as follows: smoking was 13.6% (95%CI: 3.2–24.0%), alcohol drinking was 47.0% (27.7–66.3%), current obesity was 22.3% (9.0–35.6%), and physical inactivity was 80.7% (55.4–106.0%). In addition, the overall prevalence rates of metabolic conditions were 25.6% (11.3–39.9%) for hypertension, 7.5% (0.2–15.2%) for diabetes, 11.8% (2.1–21.5%) for high cholesterol, and 13.0% (2.8–23.2%) for cardiovascular diseases. Additionally, a higher prevalence of high cholesterol was observed in men, and a greater prevalence of heart disease was identified in women. Multinomial logistic regression revealed that physical inactivity was associated with hypertension, diabetes, and heart disease, while obesity was linked to hypertension, high cholesterol, and heart disease.DiscussionThis study in West Kazakhstan identified variations in the prevalence of behavioral risk factors and NCDs, highlighting gender, age, and regional disparities. Notably, men showed higher rates of smoking and alcohol drinking, while women exhibited a greater prevalence of physical inactivity and obesity. Gender and regional differences were evident, with the West Kazakhstan region standing out for distinct patterns. Tailored interventions are crucial to address these disparities and enhance public health in the region.
Association between physical activity and sleep quality among healthcare students
Authors: Alhusami MinatAllah , Jatan Noora , Dsouza Skylar , Sultan Meshal A. 
Published: February 2024

ObjectiveTo assess the relationship between physical activity (PA) and sleep quality (SQ) in Mohammed Bin Rashid University (MBRU) students in Dubai, United Arab Emirates. Taking into account this being one of the first studies exploring this aspect among healthcare students in the Gulf Cooperation Council (GCC) countries.MethodsThis is an analytical cross-sectional study that involved disseminating online surveys via email to students of all 5 colleges in MBRU between March-June 2023. The survey encompassed queries on demographics, the Saltin-Grimby Physical Activity Level Scale (SGPALS), the International Physical Activity Questionnaire-Short Form (IPAQ-SF), and the Pittsburgh Sleep Quality Index (PSQI).ResultsThe survey was completed by 105 students. Most students were from the medical college (98/105; 93.3%) and were females (84/105; 80.0%). Females engaged the most in low PA (44.0%) while males engaged the most in high PA (42.9%) according to the IPAQ-SF. There was a significant association between SGPALS and gender (p = 0.007, X2 = 12.0). The global PSQI score showed that 70.5% of the students had bad-quality sleep. Sleep efficiency and leisurely PA are significantly negatively correlated (p = 0.026, ρ = −0.217) while sitting minutes and sleep duration are significantly positively correlated (p = 0.030, r = 0.212).ConclusionSignificant negative correlations between sleep efficiency and leisurely PA demonstrate that while exercise has been implicated in the improvement of SQ, excessive exercise can behave as an additional stressor and induce negative changes in the SQ of healthcare students. Meanwhile, significant positive correlations between sleep duration and sitting indicate that adequate rest should not be undervalued in its effects on sleep. Furthermore, the findings of this study highlight public health implications that warrant attention by educators and policymakers in academic health systems.
Enhancing Structural Diversity of Lathyrane Derivatives through Biotransformation by the Marine-Derived Actinomycete Streptomyces puniceus BC-5GB.11
Authors: Escobar-Montaño Felipe , González-Rodríguez Victoria E. , Macías-Sánchez Antonio J. , Botubol-Ares José M. , Durán-Patrón Rosa , Hernández-Galán Rosario 
Published: February 2024

Lathyrane-type diterpenes have a wide range of biological activities. Among them, euphoboetirane A (1) exerts neurogenesis-promoting activity. In order to increase the structural diversity of this type of lathyrane and explore its potential use in neurodegenerative disorders, the biotransformation of 1 by Streptomyces puniceus BC-5GB.11 has been investigated. The strain BC-5GB.11, isolated from surface sediments collected from the intertidal zone of the inner Bay of Cadiz, was identified as Streptomyces puniceus, as determined by phylogenetic analysis using 16S rRNA gene sequence. Biotransformation of 1 by BC-5GB.11 afforded five products (3–7), all of which were reported here for the first time. The main biotransformation pathways involved regioselective oxidation at non-activated carbons (3–5) and isomerization of the ∆12,13 double bond (6). In addition, a cyclopropane-rearranged compound was found (7). The structures of all compounds were elucidated on the basis of extensive NMR and HRESIMS spectroscopic studies.
Acute and Chronic Kidney Disease Worsen Outcomes in Experimental Sepsis
Authors: Floyd Deana , Colbert James F. , Feng Frances , Furgeson Seth B. , Montford John R. 
Published: February 2024

Key Points

Acute kidney disease (AKD) and CKD are common conditions associated with high rates of incident infection, and poor outcomes once infection have been established.We successfully modeled AKD and CKD in rodents and then administered a cecal slurry solution to create peritonitis and tracked sepsis severity, end organ injury, and inflammatory changes.Our results indicate that AKD mice are more susceptible to infection than CKD mice, developing an aggravated inflammatory response and suggests that this condition predisposes to disparate infection risk.

Background
Infection is a leading cause of morbidity in individuals with acute kidney disease (AKD) and CKD. However, there is significant difficulty in modeling infection into an animal host with preexisting kidney disease. We report a novel method of peritoneal infection induced via cecal slurry (CS) inoculation deployed into mice with experimental aristolochic acid–induced AKD and CKD.

Methods
AKD, CKD, and paired control mice were injected with sham, low, or higher doses of donor–recipient matched CS solution. Animal survival, sepsis severity, and change in GFR were tracked longitudinally throughout the study. Histology for kidney injury, flow cytometry, plasma cytokines, and evidence of indirect organ injury from sepsis were also assessed.

Results
Infected AKD mice experienced significantly heightened sepsis severity, with 100% mortality by 24 hours after high CS doses versus no mortality in control mice. In addition, AKD mice receiving lower CS doses developed dramatically increased proinflammatory cytokines and persistent cytopenias. Infected CKD mice also had worse outcomes than paired CKD controls, although less severe than in AKD mice. Interestingly, animals with AKD had worse outcomes than mice with CKD after any CS dose or time point after inoculation, despite higher baseline kidney function and less uremic sequela.

Conclusions
These data confirm that acute bacterial infection can be modeled in animals with established kidney disease and suggest that the clinical state of kidney disease (AKD versus CKD) may influence host susceptibility to infection more than the degree of kidney failure alone.
Impression of COVID-19 on the Life Years of Inhabitants in Tamil Nadu, India
Authors: Priya P Devi 
Published: February 2024

COVID-19 posed a threat to humankind’s ability to live and survive. The excessive infection and fatality would result in a fall in life expectancy. The pioneer study in India concluded that the lagged case fatality rate was fluctuating in the early days of infection. It was projected that if infection reaches 0.5 percent by the end of 2020, the longevity reduction would be 0.8 years (Mohanty et al., 2020). As of December 26th, 2021 Tamil Nadu stood fourth with the most epidemic cases in the country. COVID-19 has an estimated incidence rate of 25 per 1000 in India. Tamil Nadu was one of the states registering an incidence rate higher than the national average (36 per 1000). The paper examines the effect of COVID-19 on life expectancy. The infection rate of the disease was higher among the males (59%) than the females (41%). The high old-age dependency ratio in the state has resulted in high fatalities among the elderly.
Determinants of Nutritional Status of the Children
Authors: Glory Joys , Indradevi S 
Published: February 2024

Particular importance is given to nutrition in nations with high socioeconomic and sanitary standards. Public health and nutrition issues stem from issues with safe drinking water, ecological sanitation, poverty, and low literacy. Undernourishment among women is a concerning issue, especially for the destitute and impoverished. A woman’s ability to make decisions may also be influenced by her role in the family, her educational background, and her job situation. A woman who is able to make her own decisions will be able to provide her child with the best food possible and realise her full potential during times of health constraints. Decisions regarding a range of issues, including personal health, child health, mobility, and daily household issues, will collectively impact her children health. The nutritional status of mothers and their offspring was shown to be highly correlated with demographic parameters such as their background, whereas the age of the children was found to be significantly correlated with nutritional status. Long-term improvements can be brought about by the use of nutritional monitoring of students as part of the school health programme, school environment enhancements, increased purchasing power, and the provision of cheap food, particularly for the less fortunate.