bluuebunny/crossref_metadata_2025_split huggingface dataset:
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vents (GRACE©): A Prospective, Multicenter, Observational Cohort Evaluating Complications Associated with Aesthetic Injectables
Authors: Enright Kaitlyn M. , Nikolis Andreas , Sampalis John 
Published: January 2025

Background: A review of Health Canada’s post-market surveillance database has revealed that the reporting of adverse events (AEs) following aesthetic injectable treatments is significantly underreported. To increase reporting, investigators have recently developed a novel Electronic Data Capture system: The Global Registry of Adverse Clinical Events (GRACE©). Objective: To identify the incidence of AEs associated with aesthetic injectable treatments. Methods: Aesthetic clinicians from 10 Canadian sites were recruited. Demographic and clinical data were recorded within the database, which included over 45 patient variables. Results: Throughout the active phase of the trial (duration: 27 months), 123,124 injectable treatments were conducted. One hundred and eleven patients, experiencing a total of 235 AEs, were entered into the portal. This equated to an AE incidence rate of 0.19%, per treatment. Thirty unique products were associated with AEs. In total, there were 112/235 (47.66%) mild, 88/235 (37.45%) moderate, and 35/235 (14.90%) severe AEs. The most common complication (n = 48/235; 20.43%) was swelling, with a prevalence of 0.04%. Of the documented AEs, only 5 were reported to other sources, including 1 case being reported to Health Canada and 4 cases to the respective product manufacturer. Conclusions: The initial feasibility of a registry assessing safety outcomes following injectable treatment has been demonstrated. Findings support that the implementation of the GRACE Portal is an effective outreach strategy for increasing AE reporting by health care professionals. The data represent a more accurate depiction of the safety profile of approved aesthetic injectables in Canada.
The impact of virtual reality on patient experience during wide-awake surgery: a randomized controlled trial
Authors: McConnell Jack , DeYoung Joshua K. , Pum John M. , Wu Mitchell , Aggarwal Nikhil , Day Charles S. 
Published: January 2025

This study aimed to establish whether virtual reality can reduce patient anxiety and improve surgical satisfaction during wide-awake local anaesthetic no tourniquet hand procedures. Previously validated questionnaires were used to assess subjective anxiety and patient satisfaction. Objective anxiety was determined using patient blood pressure and heart rate measured four times during the procedure. The median difference in intra-operative minus pre-operative diastolic blood pressure was significantly lower in the virtual reality group compared with the control group ( p = 0.003). There was a significant decrease in heart rate from pre-operative to post-operative within the virtual reality group ( p < 0.001). No differences were observed in subjective anxiety or surgical satisfaction between the groups. Virtual reality can benefit wide-awake patients during hand procedures, particularly where patient preference exists. Level of evidence: Level I, Randomized Controlled Trial
Secondary Budd–Chiari syndrome caused by renal cell carcinoma with hepatic vein invasion: case report
Authors: Ibrahim Adil , Ahmed Tasabeeh , Khalid Rayan , Fadl-Elmula Imad 
Published: January 2025

Abstract

Background
Budd–Chiari syndrome (BCS) is a rare condition characterized by the blockage of the hepatic venous outflow tract. Primary Budd–Chiari syndrome occurs when the blockage is primarily due to a venous process such as thrombosis or phlebitis. In contrast, secondary BCS is caused by the compression or invasion of the hepatic veins and/or the inferior vena cava by a lesion originating outside the vein, such as a malignancy.

Case presentation
We present a unique case involving a large renal cell tumor that extended into the inferior vena cava and necessitated a referral for radical nephrectomy from a regional hospital. Unexpectedly, 2 days prior to the surgery, the patient deteriorated and developed secondary Budd–Chiari syndrome, which was confirmed by an abdominal CT scan revealing the tumor's extension into the hepatic veins. Before the best treatment option decided, a hepatologist was call for consultations and according to him surgical intervention with a post-operative anticoagulant therapy is the best option due to the extension of a tumor thrombus. Right radical nephrectomy involves the exploration and evacuation of a tumor thrombus from the renal vein, inferior vena cava, and hepatic vein was done. Following an uneventful postoperative period, the patient was discharged in good condition and referred to the oncology department for further management.

Conclusions
This situation highlights the need to consider the possibility of secondary Budd–Chiari syndrome in patients with large renal cell carcinoma. Being aware of this potential complication may help improve patient outcomes, especially in areas with limited healthcare resources, where late diagnoses of large renal cell carcinoma are frequent.
Osteology and functional morphology of a transitional pterosaur Dearc sgiathanach from the Middle Jurassic (Bathonian) of Scotland
Authors: Jagielska Natalia , O’Sullivan Michael , Butler Ian B. , Challands Thomas J. , Funston Gregory F. , Ross Dugald , Penny Amelia , Brusatte Stephen L. 
Published: January 2025

Abstract
Pterosaurs were the first vertebrates to evolve active flight. The lack of many well-preserved pterosaur fossils limits our understanding of the functional anatomy and behavior of these flight pioneers, particularly from their early history (Triassic to Middle Jurassic). Here we describe in detail the osteology of an exceptionally preserved Middle Jurassic pterosaur, the holotype of Dearc sgiathanach from the Isle of Skye, Scotland. We identify new autapomorphies of the flight apparatus (humerus and sternum), which further support the distinctiveness of Dearc compared with other early-diverging pterosaurs and describe features, such as the vertebral morphology, shared with later-diverging pterosaurs that probably developed convergently to support a large body size or as a sign of modular evolution. We used extant phylogenetic bracketing to infer the principal cranial and antebrachial musculature, indicating that Dearc had large and anteriorly placed palatal musculature that compensated for weak temporal jaw adductors and wing musculature suggestive of flight style reliant on powerful adduction and protraction of the humerus. Comparisons with other pterosaurs revealed that non-pterodactyloids such as Dearc, despite their overall conservative bauplans, adapted various flight and feeding styles. The osteology and myology of Dearc are indicative of a large predator that flew and hunted above lagoons and nearshore environments of the Middle Jurassic.
Dissecting the genetic basis of fruiting efficiency for genetic enhancement of harvest index, grain number, and yield in wheat
Authors: Shahi Dipendra , Guo Jia , Babar Md Ali , Pradhan Sumit , AVCI Muhsin , McBreen Jordan , Liu Zhao , Bai Guihua , Amand Paul St. , Bernardo Amy , Reynolds Matthew , Molero Gemma , Sukumaran Sivakumar , Foulkes John , Khan Jahangir 
Published: January 2025

Abstract

Background
Grain number (GN) is one of the key yield contributing factors in modern wheat (Triticum aestivum) varieties. Fruiting efficiency (FE) is a key trait for increasing GN by making more spike assimilates available to reproductive structures. Thousand grain weight (TGW) is also an important component of grain yield. To understand the genetic architecture of FE and TGW, we performed a genome-wide association study (GWAS) in a panel of 236 US soft facultative wheats that were phenotyped in three experiments at two locations in Florida and genotyped with 20,706 single nucleotide polymorphisms (SNPs) generated from genotyping-by-sequencing (GBS).

Results
FE showed significant positive associations with GN, grain yield (GY), and harvest index (HI). Likewise, TGW mostly had a positive correlation with GY and HI, but a negative correlation with GN. Eighteen marker-trait associations (MTAs) for FE and TGW were identified on 11 chromosomes, with nine MTAs within genes. Several MTAs associated with other traits were found within genes with different biological and metabolic functions including nuclear pore complex protein, F-box protein, oligopeptide transporter, and glycoside vacuolar protein. Two KASP markers showed significant mean differences for FE and TGW traits in a validation population.

Conclusions
KASP marker development and validation demonstrated the utility of these markers for improving FE and TGW in breeding programs. The results suggest that optimizing intra-spike partitioning and utilizing marker-assisted selection (MAS) can enhance GY and HI.
Comparative evaluation of antifungal susceptibility testing methods of invasive Candida species and detection of FKS genes mutations in caspofungin intermediate and resistant isolates
Authors: ElFeky Dalia Saad , El-Wakil Doaa Mahdy , Mwafy Mai M. , Atia Mohamed M.A. , Gohar Noha Mahmoud 
Published: January 2025

Abstract

Background
Fungal invasive infections caused by Candida species pose a substantial public health risk with limited therapeutic options. Antifungal susceptibility testing (AFST) is necessary to optimize the therapy. The study aimed to compare different AFST methods of Candida spp. and detect FKS gene mutations among caspofungin-intermediate and resistant isolates.

Methods
A total of 60 non-replicative invasive Candida isolates recovered from various clinical samples were included. In-vitro AFST was carried out using the ATB FUNGUS 3, Vitek-2 AST-YS08, and E-test. Hotspot (HS) regions of FKS genes were sequenced for caspofungin-intermediate and resistant isolates.

Results

Candida albicans (58.3%) was the most predominant spp., followed by C. glabrata (28.3%). Based on the clinical breakpoints (CBPs), fluconazole resistance was found in C. albicans (45.7%), C. tropicalis (25%), and the C. parapsilosis isolate, while 35.3% of C. glabrata were susceptible dose-dependent (SDD). None of C. albicans, C. tropicalis, or C. parapsilosis isolates were resistant to voriconazole. Using the epidemiological cut-off values (ECVs) for amphotericin B, 6.7% of isolates were non-wild type (non-WT), including C. guilliermondii (50%), C. tropicalis (25%), and C. glabrata (11.8%), while all C. albicans, C. parapsilosis, and C. kefyr isolates were classified as wild-type (WT). ATB FUNGUS 3 and Vitek-2 had the highest categorical agreement (CA) (83.1%) for amphotericin B, while a lower concordance was detected with voriconazole (23.2%) and fluconazole (52.2%). For caspofungin, Vitek-2 and E-test had a CA of 89.8%. Eleven isolates (10 C. glabrata and one C. parapsilosis) exhibited resistance or intermediate susceptibility to caspofungin (MICs: 0.25‒>32 µg/ml). Molecular characterization of the FKS gene demonstrated that FKS1 mutations V47I, V52K, V56T, D57S, L62F, I71Y, I71Q in the HS1 region, and G7S, P11H mutations in the HS2 region were associated with increased caspofungin MIC values (16 µg/ml). Mutations at the HS1 of the FKS2 gene; K33V, W35K, and W35V; were associated with the highest caspofungin MICs of > 32 µg/ml.

Conclusions
ATB FUNGUS 3 demonstrated acceptable performance for AFST, however, azole activity against Candida spp. should be interpreted carefully. Novel mutations within HS regions of FKS genes elucidated different levels of caspofungin resistance in C. glabrata and C. parapsilosis isolates.
Socioeconomic inequalities in health behaviors in children and adolescents: evidence from an Australian cohort
Authors: Gautam Nirmal , Rahman Mohammad Mafizur , Khanam Rasheda 
Published: January 2025

Abstract

Background
Understanding the association between socioeconomic inequalities and health behaviors is imperative for elucidating and effectively addressing health inequities among children and adolescents. Despite the wealth of literature on social gradients in health behaviors, longitudinal analyses of socioeconomic inequalities in the health behaviors of children and adolescents are relatively limited, particularly in the Australian literature. Therefore, this study aimed to investigate the association between socioeconomic inequalities and health behaviors among Australian children and adolescents.

Methods
This study utilized the secondary data from the Longitudinal Study of Australian Children (Waves 2–8), which included participants aged 2 to 15 years. Relative index inequality (RII) methods were used to investigate the associations between socioeconomic inequalities and the health behaviors of children and adolescents.

Results
Compared with their counterparts, children and adolescents with high socioeconomic status (SES) are 84% more likely to consume fruits and vegetables (RII = 1.84, 95% CI = 1.63–2.09) and 19% less likely to consume sugary beverages (RII = 0.81, 95% CI = 0.77–0.86), but more likely to consume sweet and savory foods (RII = 1.09, 95% CI = 1.01–1.19). Children and adolescents with high SES were less likely to spend their free time on screens (RII = 0.86, 95% CI = 0.81–0.91) and more inclined toward outdoor activities (RII = 1.75, 95% CI = 1.53–1.98).

Conclusion
This study provides useful insight into socioeconomic inequalities and health behavior outcomes in children and adolescents. These findings stress the need for tailored interventions designed to improve the health behaviors of families from lower socioeconomic backgrounds. Additionally, addressing unhealthy dietary behaviors, such as the higher consumption of sweet and savory foods among children from higher SES backgrounds, is equally critical. Such comprehensive interventions have the potential to reduce socioeconomic disparities in health behaviors and improve the well-being of the broader population.
Knowledge, attitudes and practices of Australian dairy goat farmers towards the control of gastrointestinal parasites
Authors: Ali Endris A. , Abbas Ghazanfar , Beveridge Ian , Baxendell Sandra , Squire Berwyn , Stevenson Mark A. , Ghafar Abdul , Jabbar Abdul 
Published: January 2025

Abstract

Background
Gastrointestinal parasites such as nematodes and coccidia are responsible for significant economic losses in the goat industry globally. An indiscriminate use of antiparasitic drugs, primarily registered for use in sheep and cattle, in goats has resulted in drug-resistant gastrointestinal parasites. Very little is known about the gastrointestinal parasite control practices used by Australian dairy goat farmers that are pivotal for achieving sustainable control of economically important parasites. The study reported here provides insights into gastrointestinal parasite control practices of Australian dairy goat farmers based on responses to an online survey.

Methods
The questionnaire comprised 58 questions on farm demography, husbandry and grazing management, knowledge of gastrointestinal parasites and their importance in dairy goats, diagnosis of infections, antiparasitic drugs and alternate control options. After a pilot survey (n = 15 respondents), a link to the questionnaire was available to all (n = 456) registered members of the Dairy Goat Society of Australia Ltd from 17 April to 16 June 2023. Multiple correspondence analyses (MCA) were performed to explore the association between selected parasite control practices.

Results
A total of 66 (14%) respondents completed the questionnaire. Of these, 74% (49/66) observed parasite-related illnesses in their goats; two-thirds of them assessed worms burden using faecal egg counts (FECs), with 26% (39/149) deworming their goats based on the results of the FECs. Most respondents (97%; 183/188) perceived that gastrointestinal parasites caused production losses and ranked Haemonchus contortus as the most important parasite. Anitparasitic drugs were used by 94% (62/66) of respondents, with the most frequently used anthelmintics being a commercial combination of four anthelmintics (levamisole, closantel, albendazole and abamectin), benzimidazoles and macrocyclic lactones. Most respondents (77%; 51/66) were unaware of anthelmintic resistance on their property. MCA results delineated two clusters of gastrointestinal parasites management.

Conclusions
This study provides insights into the demography of Australian dairy goat farms, the husbandry and grazing practices used by dairy goat farmers, their knowledge regarding gastrointestinal parasites and their practices for internal parasite control, thereby paving the way for tackling drug resistance in gastrointestinal parasites in dairy goats.

Graphical Abstract
Development of a GIS-based register of biogas plant sites in Lower Saxony, Germany: a foundation for identifying P2G potential
Authors: Plinke Mareike , Berndmeyer Jonas , Hack Jochen 
Published: January 2025

Abstract

Background
Although Germany’s biogas capacity accounts for almost 7% of its installed worldwide capacity, the expansion of biogas plants has stagnated owing to the expiry of Germany’s Renewable Energy Sources Act Erneuerbare–Energien–Gesetz (EEG) subsidies for existing biogas plants. Indeed, without alternative concepts such as power-to-gas (P2G) ensuring their continuing operation, many existing biogas plants must close down to ensure their continuous operation. A detailed spatial register of biogas plant sites must be developed to evaluate the potential for further operation (and thereby promote Germany’s sustainable energy transition). In particular, Lower Saxony, a German federal state, was hit hardest by the expiry of subsidies, as there is a lack of spatially high-resolution information to identify which biogas plants have P2G potential as an end-of-subsidy strategy. This study discusses the development of a geographic information system-based register for these plants.

Methods
A register was developed using geographic information system (GIS). Spatial data on existing biogas plants in Lower Saxony were selected from the Digital Landscape Model (DLM) data, with additional information coming inter alia from the Marktstammdatenregister, the Germany-wide core energy market data register. The data were merged into a single register for Lower Saxony, and aerial photographs were used to validate the biogas plant site.

Results
A total of 1704 biogas plant sites were identified throughout Lower Saxony. Spatially resolved plant information on production capacity suggests that three quarters are suitable for inclusion in a methanization concept. Because plants at 85% of the sites will no longer be subsidised by 2035, end-of-subsidy strategies will soon become relevant.

Conclusions
The GIS-based analysis is a reliable and low-error method for identifying biogas plant sites in Lower Saxony. Almost all plants were included in the registry. The greatest advantages over existing registers and at the same time the unique characteristics of our register were the exact spatial localisation of the plants and the highly up-to-date nature of the data. The register enables the initial (spatial) identification, characterisation, and analysis of potential sites for P2G end-of-subsidy strategies. Overall, the register has significant potential as an advisory basis.
Market-based or policy strategies to increase the cultivation of legumes for livestock? Effects on the cropping pattern and economic performance
Authors: Michalis Efstratios , Ragkos Athanasios , Malesios Chrysovalantis 
Published: January 2025

Abstract
Legume crops, the production of which is related to their use in animal nutrition (referred to in this study as “legumes for livestock—LL” and include species such as bean, lupin, pea, vetch and clover), have positive effects on the economic performance of farms and environmental outcomes, although their relation to sustainable weed management practices (SWMP) has received limited attention. The expansion of LL in Europe is limited due to market constraints, despite important policy incentives. This study was designed to investigate whether a policy-oriented Scenario (S1) or a market-based Scenario (S2) could induce the expansion of the cultivation of LL as well as to examine the possible impact on the economic performance of farming systems, including cost savings related to pest management. A farm typology was developed according to the level of expenses of farms for crop protection and their implemented SWMP. Using technical and economic data from 45 farms that cultivate annual arable crops in Greece, with special emphasis on LL, a Linear Programming model was constructed to examine the potential role of each one of the three identified farm types in the expansion of LL in Central Greece (Baseline Solution—BS). Following the BS, the effects of the two Scenarios were examined through a Price Parametric Programming approach. The solutions revealed that the valorization of LL had a significant economic potential for all farm types. In addition, it was found that a substantial policy incentive of increasing the coupled payments of LL by 128% (S1) can have an equivalent impact on the expansion of LL as modest levels of market interventions—through the achievement of higher yields or/and higher selling prices—to increase the revenues of LL by 59% (S2). Farms that relied more on chemical pesticides could play a more decisive role in expanding LL. The novel aspect is related to the investigation of the economic performance of different farm types cultivating LL with a specific focus on potentially higher profitability related to SWMP. Furthermore, this study contributed to the “policy versus market solutions” debate toward the expansion of LL.
Exploring consumer preferences and policy implications in local food systems: Does taste or labeling matter in honey?
Authors: Lopéz-Galán Belinda , de-Magistris Tiziana 
Published: January 2025

Abstract
This study analyses the influence of geographical origin and taste on honey consumer behavior. First, we explore the influence of geographical origin on consumers’ hedonic evaluation of honey. We then assess the influence of geographical origin and taste on their willingness to pay (WTP) for honey. We conducted a field experiment at a real supermarket. The participants were exposed to two treatments (blind and informed treatment). The findings showed that knowledge about the geographical origin of honey influences consumers’ hedonic evaluations and that the WTP for honey is more strongly influenced by geographical origin than by taste.
Simultaneous transcatheter aortic valve implantation and femoral osteosynthesis: a case report
Authors: Mitsuta Yuki , Okamura Yukiko , Miyamoto Yosuke , Tanahira Dai 
Published: January 2025

Abstract

Background
Simultaneous cardiac and non-cardiac surgeries can be beneficial for patients, but there are still few reports on this approach.

Case presentation
A 90-year-old woman was diagnosed with a femoral trochanteric fracture and severe aortic stenosis. A heart team conference decided to perform transcatheter aortic valve implantation (TAVI) and femoral osteosynthesis under general anesthesia on the same day. A preoperative simulation was conducted to review the surgical procedure and confirm the arrangement of the operating table and instruments. Preoperative management was carried out with attention to the risk of myocardial ischemia caused by bleeding or pain from the fracture. Transfemoral TAVI was completed without trouble, and after the patient was moved to the traction table, osteosynthesis was started. Back-up pacing with a temporary pacemaker was activated for atrioventricular block and bradycardia. After completing the surgery, the patient recovered from anesthesia, and extubation was performed after confirming the absence of paralysis. The patient had no noticeable postoperative complications and successfully underwent rehabilitation.

Conclusions
Through meticulous preparation and perioperative management, we were able to perform TAVI and femoral osteosynthesis simultaneously, achieving a favorable outcome.