bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Do we need an alternative to polyvinylidene fluoride-based membranes and where will it come from?
Authors: Hoek Eric , Xiao Minhao , Ozdemir Burcu , Yang Fan , Wang Xinyi , Wu Jishan , Rosa Igor , Hollister John Hollister , Dlamini Derrick , Quezada-Renteria Javier , Schroeder Kurt Schroeder , Wagh Priyesh , Prata Joseph , Pafford Margaret , Kavehpour Pirouz , Jassby David Jassby 
Published: December 2023

Abstract
Recently, there has been widespread news coverage regarding the potential ban on polyvinylidene fluoride (PVDF) as one of thousands of per- and poly-fluoroalkyl compounds by the European Union, the United States and several U.S. states including California (the 5th largest economy in the world). This could greatly impact the membrane manufacturing industry as well as its downstream users in biopharma, automotive, water, dairy, food and beverage industries. Herein, we evaluate the performance and physical-chemical properties of membranes made from PVDF, polyethersulfone (PES) and chlorinated polyvinyl chloride (CPVC) polymers. Both PVDF and PES are widely used in commercial membrane products, but CPVC – while used extensively in water, harsh chemicals, and high temperature piping systems – has not been widely explored as a polymer for use in filtration membranes. We fabricate a series of tight, mesoporous ultrafiltration membranes by a simple nonsolvent induced phase separation (NIPS) process, and systematically characterize and quantitatively rate the performance and physical-chemical properties of all three polymers. All three polymers produce membranes with excellent separation performance and thermal, chemical and mechanical stability. Finally, we explore a range of casting conditions for CPVC to evaluate its potential to make membranes with performance spanning the range of tight UF (typically served by PES) to standard MF (typically served by PVDF). CPVC appears to a viable alternative to both PES and PVDF as it spans the entire range of UF and MF separation performance while offering excellent pure water permeability and solute rejection as well as thermal, chemical, and mechanical stability.
Factors influencing the outcome of hip preservation in femoral head necrosis treated with rotational osteotomy via the base of the femoral neck, combined with finite element analysis
Authors: Sun Jiahao , Bowen Ma , Zhiguang Zhang , Tianwei XIA , Rong SHEN Ji , Zhiyuan CHEN 
Published: December 2023

Abstract
Background :The tip-apex distance (TAD), calcar referenced tip-apex distance (Cal-TAD), and neck-shaft angle (NSA) demonstrate reliability in predicting outcomes following internal fixation of femoral neck fractures. However, the potential influence of TAD, Cal-TAD, and NSA on predicting hip preservation outcomes through trans-trochanteric rotational osteotomy at the base of the femoral neck for treating femoral head necrosis remains unexplored.
Purposes: To assess the prognostic value of TAD, Cal-TAD, and NSA for hip preservation outcomes following rotational osteotomy at the base of the femoral neck in conjunction with finite element analysis, we compared the outcomes of different patients who underwent this procedure for femoral head necrosis.
Methods: The clinical data of 33 patients (33 hips) who underwent rotational osteotomy at the base of the femoral neck between January 2017 and December 2021 in our hospital were retrospectively analyzed. TAD, Cal-TAD, and NSA were measured on immediate postoperative radiographs, and the patients were categorized into Alive and Dead groups based on hip preservation outcomes for statistical analysis. Additionally, three-dimensional models with varying neck shaft angles were constructed to examine changes in maximum displacement of the femoral head and stress on the osteotomy surface.
Results:During a mean follow-up period of approximately 40 months, 26 patients survived while 7 patients experienced hip preservation failure. The differences in age, TAD, and Cal-TAD between the two groups were not statistically significant (P>0.05), whereas NSA exhibited statistical significance (P<0.05). Biomechanical analysis revealed a close association between NSA and postoperative biomechanical changes.
Conclusion: When performing rotational osteotomy at the base of the femoral neck for the treatment of femoral head necrosis, both TAD and Cal-TAD exhibit negligible impact on hip preservation outcomes, while the size of NSA significantly influences surgical success rates. Therefore, meticulous attention should be given to precise measurement and adjustment of NSA during surgery in order to achieve optimal surgical outcomes.
Identification and cytological observation of CMS in cotton
Authors: PEI Qingyu , LIU Jinshan , GUO Chunping , MA Xiaomei , LIU Xiaoyan , YOU Chunyuan , LIN Hairong , LI Zhibo , ZHAO Ruihai , ZHU Bo , WU Yuanlong , PAN Zhenyuan , Nie Xinhui 
Published: December 2023

Abstract

Background The utilization of male sterility is essential for producing hybrid seeds, and comprehending the mechanism of male sterility is the foundation for developing sterile germplasm resources. However, only a few cytoplasmic male sterility (CMS) lines of cotton have been produced due to various hindrances. Inadequate agronomic traits and incomplete sterility, weak resilience of restorer lines and the difficulty in combining strong dominance all serve as primary impediments to the advancement of CMS in cotton. Therefore, identifying and cytologically observing of CMS in cotton will provide new insights for heterosis utilization.
Results Two F2 segregating populations of cotton were constructed from cytoplasmic sterile lines (HaA and 01A, maternal) and restorer lines (HaR and 26R, paternal). Genetic analysis of F2 segregation populations showed that the separation ratio of fertile to sterile plants was 3:1. Phenotypic analysis indicated that there was no significant difference in the development process of flower buds between sterile and fertile plants. Compared to fertile plants, sterile plants exhibit smaller floral organs, shortened filament length and anther atrophy on the day of flowering. Scanning electron microscopy (SEM) of two F2 populations revealed morphological variations in the folds of the anther epidermis. Analysis of cell level differences showed that there was no significant difference in pollen development before the pollen maturation stage. However, between pollen maturation stage and flowering stage, the tapetum layer of sterile plants degenerated prematurely, the pollen grains were abnormal, pollen cytoplasmic degradation and gradually hollowed out.
Conclusion The sterile trait is controlled by a single recessive gene. The floral morphology of the sterile plant was characterized by stamen atrophy and abnormal anthers. Pollen abortion occurs from the time of pollen maturity until flowering. Degradation of pollen grains and the formation of empty pollen grains due to the premature degradation of the tapetum are presumed to be the main cause for pollen abortion.
Hemodynamic response to tilt test with impedance cardiography in patients with atrial fibrillation.
Authors: Magajevski Adriano Senter , Távora-Mehta Maria Zildany P. , Mehta Niraj , Maluf Débora L. Smith , Silva Edvaldo Pinheiro , Concato Leticia , Ortiz Marcio Rogerio , Doubrawa Eduardo , Lofrano-Alves Marco Stephan 
Published: December 2023

Abstract

Background Hemodynamic response during transition from supine to standing position in idiopathic atrial fibrillation (AF) is not completely understood. Objective This study aims to analyze the hemodynamic changes during the head-up tilt test in idiopathic AF patients. Methods We investigated the hemodynamic changes during the head-up tilt test with impedance cardiography in 40 AF patients (12 AF rhythm-AFr, and 28 sinus rhythm-AFsr) and 38 non-AF. Results Patients in AFr showed attenuated SVI drop after standing in comparison to AFsr and non-AF [ΔSVI in mL/m2: -1.3(-3.4 to 1.7) vs. -6.4(-17.3 to -0.1) vs. -11.8(-18.7 to -8.0), respectively, p < 0.001]. PVRI decreased in AFr, while increased in AFsr and non-AF [ΔPVRI in dyne.seg.m2/cm5: -477(-1148 to 82.5) vs. 131(-525 to 887) vs. 357(-29 to 681), respectively, p < 0.01]. AFr also showed higher HR and greater CI increase after standing compared to non-AF. Linear regression demonstrated negative relationship of ΔPVRI and ΔSVI, with significant difference between AF rhythm and sinus rhythm for slopes [-171(-228 to -113) vs. -46(-58 to -34), p < 0.0001] and intercepts [-727 (-1040 to -414) vs -217(-392 to -42), p < 0.05]. Conclusions the hemodynamic response to orthostatic challenge suggests differential adaptations of the autonomic nervous system between patients with AF rhythm and those reverted to sinus rhythm or healthy controls. The relationship between PVRI and SVI may be a therapeutic target in AF.
The power spectrum indicator, a new and fast method for the early
detection of chaos.
Authors: Vozikis Christos , Kleidis Konstantinos , Papaioannou Stavros 
Published: December 2023

Abstract

To determine the regular or chaotic nature of the orbits in dynamical
systems can be quite an issue. In
this article, following \cite{Vozikis}, we propose a new tool, namely,
the Power Spectrum Indicator (PSI), $\psi^2$, that enables us to determine, as
early as posible, whether an orbit of a two-dimensional map is chaotic or
not. This new method is based on the frequency analysis of a data series
constucted by recording the logarithm of the amplification factor of the
deviation vector of nearby orbits. Accordingly, two datasets are recorded and
the $\chi^2$-likelyhood of their power spectra is computed. Ordered orbits
have always the same power spectrum, so their $\chi^2 \equiv \psi^2$ acquires
a zero value. On the contrary, a chaotic orbit has a power spectrum that
varies with time, hence, chaotic orbits always exhibit a non-zero $\psi^2$
value. Even as regards {\it "sticky"} orbits, the PSI method is very effective
in the early detection of chaos, while the global behavior of the $\psi^2$
indicator can provide information (also) on the intense of the chaotic
behavior, i.e., on how {\it "strong"} or {\it "weak"} the associated chaos may
be.
Accuracy Study of Smartwatch in Predicting Running Performance Across Various Distances: A Scientific Investigation
Authors: Dai Jiansong , Chen Gangrui , Gu Zhongke , Qi Yuxuan , Xu Kai 
Published: December 2023

Abstract
BACKGROUND
Smartwatches for running are highly prevalent among amateur runners. Their reliability and validity need investigation for accurate predicting running performance.
OBJECTIVE
This study aims to examine the accuracy of the HUAWEI WATCH GT Runner smartwatch in predicting running performance.
METHODS
A total of 154 amateur runners, comprising 123 men and 31 women, were recruited. After wearing the HUAWEI WATCH GT Runner for a minimum of six weeks, the runners' actual completion times for 5km, 10km, and half marathon distances were measured, resulting in 288 test instances. The predicted completion times for the same distances as displayed on the watch on the day of the test were simultaneously recorded.
RESULTS
The actual and predicted performances for the 5km, 10km, and 21.1km distances were highly correlated, with r ≥ 0.95 (P < 0.001), r2 ≥ 0.9 for all three distances, and an error rate between the measured and predicted values of less than 3%, and ICC ≥ 0.9. The Bias ± 95%LoA was − 20.6 ± 46.1 seconds for the 5km, 4.1 ± 299.1 seconds for the 10km, and 143.8 ± 400.4 seconds for the half marathon.
CONCLUSIONS
This study confirms that the smartwatch exhibits high precision in predicting 5km, 10km, and half marathon performances, with an accuracy exceeding 97%. The performance prediction feature of the smartwatch can effectively guide amateur runners in setting reasonable competition goals and preparing for races.
Responses of the European IoT Ecosystem to the European General Data Protection Regulation
Authors: Ebbers Frank , Friedewald Michael 
Published: December 2023

Abstract

With the proliferation of IoT devices in homes and industry, concerns have arisen about the security of the devices and the privacy of users. The General Data Protection Regulation (GDPR), which went into effect in 2018, aims to protect the rights of IoT (and other) users. One way for device manufacturers to address these rights is through firmware updates. However, the extent of the GDPR's impact on EU member states remains uncertain. This paper presents a comprehensive analysis that examines changes in firmware age, as well as the overall age of devices, following the implementation of GDPR in the EU. The analysis uses approximately 400 terabytes of real-world IoT data from Censys.io, spanning from 2015 to the end of 2021. Using grouped average age values, we perform and compare difference-in-differences analyses for devices deployed in all EU member states and regions. We show that devices deployed in Northern Europe tend to be the most up-to-date, while Eastern Europe lags behind. This work provides initial insights into the impact of the GDPR in the IoT ecosystem, and highlights the need for further research to gain a deeper understanding of the effects.
Computed Entropy Spectra for Grain Boundary Segregation in Polycrystals
Authors: Schuh Christopher , Tuchinda Nutth 
Published: December 2023

Abstract
Grain boundary solute segregation influences most bulk material properties, and understanding solute thermodynamics at grain boundaries is critical for engineering them. However, the vast grain boundary space in polycrystals is challenging to evaluate due to its size, especially for the intrinsically hard-to-compute segregation excess entropy. Here data science methods are used to generate a database of site-wise grain boundary segregation entropy spectra for 155 dilute binary alloys within the harmonic approximation. The spectral framework allows scale bridging between the calculated atomistic site-wise energy-entropy spectra and macroscopic segregation entropy estimates. The results affirm that such macroscopic averaging is not sufficient: a spectral treatment of grain boundary segregation is needed to accurately model bulk temperature dependence of grain boundary solute segregation. The calculated spectral entropy database and thermodynamic framework can be applied for both understanding segregation experiments and alloy design exercises, paving the way to a finite-temperature grain boundary genome.
Economics of Homestead Coffee Production in Southern Ethiopia: A promising approach to enhance household asset building
Authors: Hailu Tegegn , Toma Senbetie , Shumbulo Abrham 
Published: December 2023

Abstract
This study explores the relationship between households' livelihoods asset building and their coffee production status in Ethiopia's central high lands. Household survey data was obtained from randomly selected 250 participants, and multidimensional statistical analysis methods were utilized. The results indicated a significant role of home garden coffee production on household livelihood asset buildings in the context of the mixed and diversified farming systems of the south Ethiopia. Household ownership, access to agricultural resource endowments, and the empowerment of human capital at the household level significantly determined livelihood dimensions and impact on household coffee production status. Farmer's motivation and practices for coffee production lies in the access and endowment of these dimensions of household asset. It was recommended that enhancing the asset capital status of rural farm households merits special attention, including their human capital, independent ownership rights over land and other resources and participation in social processes.
Preoperative neutrophil-to-lymphocyte ratio predicts recurrence of esophageal squamous cell carcinoma after neoadjuvant triplet chemotherapy
Authors: Kubo Kentaro , Igaue Shota , Utsunomiya Daichi , Kubo Yuto , Kanematsu Kyohei , Kurita Daisuke , Ishiyama Koshiro , Oguma Junya , Goto Koichi , Daiko Hiroyuki 
Published: December 2023

Abstract
Background. Neoadjuvant chemotherapy followed by esophagectomy is the standard treatment for resectable advanced esophageal squamous cell carcinoma (ESCC) in Japan. Triplet chemotherapy is the standard neoadjuvant regimen. Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) are well-known prognostic factors for esophageal cancer. However, their usefulness in patients with resectable advanced disease undergoing esophagectomy after neoadjuvant triplet chemotherapy is unknown.Method. We examined 144 ESCC patients who underwent neoadjuvant triplet chemotherapy followed by esophagectomy between January 2015 to December 2020 to investigate the relationship between inflammatory markers and recurrence-free survival (RFS). Optimal marker cutoff values for RFS were determined using receiver operating characteristic curve analysis. Patients were divided into high and low NLR groups (NLR cutoff, 3.0).Results. NLR was high in 61 patients and low in 83. Univariate analyses demonstrated that low NLR was significantly associated with worse RFS (p = 0.049). Multivariate analyses demonstrated that high NLR was an independent predictor of RFS (odds ratio, 1.911; 95% confidence interval, 1.098–3.327; p = 0.022). RFS significantly differed between the low and high NLR groups. RFS did not significantly differ between the patients when stratified according to the other inflammatory markers.Conclusion. Preoperative NLR is an easily obtained and useful predictor of RFS in patients with resectable advanced ESCC treated with neoadjuvant triplet chemotherapy followed by esophagectomy.
Unveiling A Hidden Burden: Exploring Sarcopenia in Hospitalized Older Patients through Concordance and Cluster Analysis
Authors: Venegas-Sanabria Luis Carlos , Borda Miguel German , Murcia-Soriano Luisa Fernanda , Ramos-Caballero Diana Marcela , Tordecilla-Sanders Maria Alejandra , Garcia-Laguna Dayana Gabriela , Vargas-Pinilla Olga 
Published: December 2023

Abstract

Background
Sarcopenia has shown to be an important condition, with the capability to predict health negative outcomes, especially in hospitalized older adults, hence its accurate identification has an important role in the prognosis of older patients.
Aim:
Assess the prevalence of sarcopenia among hospitalized older adults by employing three distinct diagnostic methods.
Methods
Older adults hospitalized were recruited. Bioelectrical impedance analysis was used to assess muscle mass and body composition. Sarcopenia was diagnosed using the European and Asian criteria, and a modified approach using Colombian cut-off points for handgrip and gait speed. Finally, a cluster analysis was performed to classify the population.
Results
Sarcopenia and severe sarcopenia prevalence ranged from 7.3% to 31.6%. The agreement between approaches revealed a substantial or almost perfect agreement in 30% of the sarcopenia comparisons and 46.6% of the severe sarcopenia comparisons. The cluster analysis defined three different clusters. The first cluster had higher age, BMI and body fat, and poorer functional status and muscle. The second cluster was the healthiest, with high functional status and muscle mass. The third cluster had intermediate characteristics.
Discussion
This study highlights the requirement for standardized diagnostic criteria and precise body composition assessment tools in acute geriatric units but also remarks on the heterogeneity of older adults. Accurate assessment and well-defined diagnostic criteria will facilitate the implementation of appropriate management and interventions.
Conclusion:
Sarcopenia is highly prevalent in hospitalized older adults, but the adjusted criteria and the inclusion of other parameters must be considered in the assessment.
Association Between Glycemic Traits and Oesophageal Cancer: a Multivariable Mendelian Randomization Study
Authors: Chen Yuxing , Zeng Qingpeng , Li Muyu , Chen Keqin , Zhao Jun 
Published: December 2023

Abstract
Background
Observational studies indicate a potential link between increased blood glucose levels and the development of oesophageal cancer. However, the causal relationship between glycemic traits and oesophageal cancer has not been clarified yet. The aim of this research was to examine if there is a genetic link between glycemic characteristics and oesophageal cancer through the use of Mendelian randomization analysis.
Methods
We conducted a TSMR analysis and MVMR using publicly available GWAS data on the European population. The primary analysis utilized the IVW method, which was subsequently validated through comprehensive complementary and sensitivity analyses.
Results
IVW analysis revealed a substantial correlation (OR = 1.612, P = 0.0228) between type 2 diabetes (T2DM) and oesophageal cancer. After accounting for body mass index (BMI), this association remained to be statistically significant in multivariate MR analyses (OR = 1.662, P = 0.0416). There was only a small amount of evidence indicating a possible link between oesophageal cancer and other glycemic traits after excluding the outliers.
Conclusions
Our study further supports the evidence that European individuals with T2DM are at an increased risk of developing oesophageal cancer. It implies that pharmacological or lifestyle treatments for individuals with T2DM could potentially be advantageous in the prevention of oesophageal tumor development.
Causal effects of reproductive behaviors on the risk of osteoarthritis and rheumatoid arthritis：A Mendelian Randomization Study
Authors: Li Wenchang , Dai Hanqiao , Bai Yunbo , Wang Zhiyong , Zhang Jingru , Li Yonggang 
Published: December 2023

Abstract
Background
Reproductive behavior leads to drastic changes in hormones, which may affect the development of arthritis, but it is uncertain whether there is a causal relationship. This study used Mendelian randomization to examine whether there is a causal relationship between female reproductive practices and arthritis.
Methods
Summary statistical data for osteoarthritis and rheumatoid arthritis originated from two genome-wide association studies (GWAS). Public GWAS data with European ancestry were exploited to identify instrumental variables of age at first birth (AFB) and age at first sexual intercourse (AFS). Subsequently, Mendelian randomization analyses were mainly conducted with the inverse variance weighted (IVW) method. Furthermore, complementary sensitivity analyses were then conducted to assess the robustness of our results.
Results
Using the IVW method, we found evidence of causal relationships between hormonal reproductive behaviors and decreased rheumatoid arthritis (RA) risk (AFB and AFS, odds ratio (OR) [95% CI], 0.837[0.747–0.938], and 0.634[0.496–0.811], respectively). Both AFB and AFS seem to be negatively associated with knee osteoarthritis (OA) risk (AFB and AFS, OR [95% CI], 0.828[0.789–0.870], and 0.537[0.470–0.811], respectively). Only AFS was negatively associated with hip OA risk. (OR [95% CI], 0.788[0.682–0.911]). The findings of this study were verified by the results from sensitivity analysis.
Conclusion
This Mendelian randomization study suggests that both AFS and AFB seem to be negatively associated with arthritis risk.