bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for central nervous system infection after craniotomy for gliomas: a 8-year experience from a tertiary medical center
Authors: Zhang Xin , Zheng Zhiyao , Guo Xiaopeng , Wang Hai , Gong Le , Liu Delin , Yang Tianrui , Song Yixuan , Huang Hongmin , Cao Yaning , Wang Yu , Guo Fuping , Ma Wenbin 
Published: February 2024

Abstract

Object: Due to the fact that glioma surgery requires manipulation of the brain parenchyma and the expression of inflammatory mediators, there is often a possibility of central nervous system (CNS) infection occurring after surgery. Previous studies on CNS infections related to neurosurgery have uniformly explored the risk factors for CNS infections in all neurosurgery surgeries that require craniotomy, but have not explored the risk factors and clinical characteristics of CNS infections after glioma resection.
Methods: We included patients who underwent glioma resection from January 2015 to March 2023, systematically recorded population characteristics, clinical, surgical, laboratory and survival data, analyzed high-risk factors for postoperative CNS infections, summarized cerebrospinal fluid characteristics, antibiotic use, and explored whether CNS infections affects the long-term prognosis of glioma patients after surgery.
Results:All 337 patients underwent glioma resection, and 61 patients (18.1%) developed CNS infections after surgery. Ventricle Opening, post-op other systemic infections, post-op maximum cavity diameter, and peripheral blood Monocyte% are independent risk factors for postoperative CNS infections. The median protein content in cerebrospinal fluid of patients with CNS infections is 1.73g/L ([IQR] 1.03-3.06), the median glucose content is 2.7mmol/L ([IQR] 1.90-3.70), and the median WBC is 1478×106cells/L ([IQR] 467-4204.25×106), with a median percentage of multinucleated cells of 84.1% ([IQR] 74.55% -90.83%). Meropenem and Vancomycin are the most commonly used antibiotics, with an average usage time of 7.79 days and 8.41 days, respectively. Survival analysis suggests that the occurrence of CNS infections does not affect the long-term prognosis of glioma patients after surgery.
Conclusions: This study separately explored the risk factors for CNS infections in patients with glioma after surgery, instead of all diseases which need craniotomy，and summarized their cerebrospinal fluid characteristics and antibiotic use. Although CNS infection is only one of the possible complications during the treatment of gliomas, we believe that this will make a certain contribution to neurosurgeons' individualized prevention, diagnosis, and treatment of patients in the diagnosis and treatment of gliomas.
Prevalence of Abuse in Women with Endometriosis and Relationship to Pain Symptoms: A Cross-Sectional Questionnaire Study
Authors: Gaerke Alyssa , Jago Caitlin Anne , Flaxman Teresa , Singh Sukhbir S. , Lortie Karine 
Published: February 2024

Abstract
Background
Sexual and physical abuse are associated with endometriosis, but their relationship to pain in endometriosis patients has not been studied. The aim of this study was to characterize the prevalence of sexual and physical abuse history in an endometriosis population and its relationship to severity and type of pain symptoms.
Methods
This was a cross-sectional questionnaire study conducted from May 2017 to May 2018 at a tertiary care gynecology clinic. Women with clinically suspected or surgically confirmed endometriosis were included. Patients completed the Endometriosis Phenome and Biobanking Harmonization Project (EPHect) Clinical Questionnaire, the International Pelvic Pain Society Pelvic Pain Assessment Form, and the Medical Outcome Survey (SF-36). Relationships between history of sexual abuse or physical abuse, pelvic pain type and severity, anxiety/depression diagnosis, quality of life, and demographics were analysed using Chi square, independent t-tests, Mann-Whitney U test, and logistic regression models.
Results
Forty-four women were surveyed. Severity and type of pain symptoms were similar in patients with and without a history of sexual or physical abuse. Forty-three percent (n = 19) of patients with endometriosis reported history of physical abuse and 43% (n = 19) reported history of sexual abuse with a 68% overlap between both groups. Patients with a history of sexual abuse had significantly higher rates of depression (53% vs 16%; p = 0.012) and anxiety (58% vs 12%; p = 0.001) than those reporting no history of sexual abuse and reported significantly lower mean SF-36 mental component summary scores (34 ± 14 vs 42 ± 12, p = 0.028).
Conclusions
No differences in severity and type of pain symptoms in patients with a history of sexual or physical abuse were observed compared to those without. More than 40% (n = 19) of patients with endometriosis reported a history of sexual abuse, with more anxiety and depression and lower mental quality of life scores compared to patients who reported no history of sexual abuse. This highlights the need for sexual abuse and mental health screening in an endometriosis population.
Association between periodontitis and depression: A two-sample bidirectional Mendelian randomization study
Authors: Feng Fan , Zhang Min 
Published: February 2024

Abstract
Background and aims: Emerging studies have identified a possible link between periodontitis and depression, but evidence regarding a causal association between periodontitis and the risk of depression is sparse and conflicting. The aim of this study was to assess the bidirectional relationship between periodontitis and depression using Mendelian randomization (MR) methodology.
Methods: The MR study was based on summary statistics for periodontitis and depression from different genome-wide association studies. We used eight independent genetic instruments for periodontitis and 90 for depression. Estimates for the association in both directions were combined using the inverse variance weighted (IVW) method, and several complementary methods were applied
Results: Standard IVW analyses showed no causal effect of genetically predicted periodontitis on depression (odds ratio [OR] 1.02, 95% confidence interval [CI] 0.99-1.05; p = 0.193) or vice versa (OR 1.04, 95% CI 0.91-1.20; p = 0.570). The results were robust in complementary analyses. No horizontal pleiotropy was detected via MR-Egger regression or in MR pleiotropy residual sum and outlier analyses.
Conclusions: The present study provides evidence that periodontitis and depression may not be mutually reinforcing.
Bilateral Sensorineural Hearing Loss After General Anesthesia for Basilar Invagination with Atlantolaxial Dislocation: a case report
Authors: Zheng Yuhao , Yang Qiyuan , Bing Tan 
Published: February 2024

Abstract
Background
Sudden sensorineural hearing loss (SNHL) after nonotological surgery is unusual and unpredictable, usually occurring in cardiopulmonary bypass patients with unilateral deafness. A few bilateral SNHLs after spine surgery is reported. The literature is examined for early detection and management, and probable causes are outlined. Timing of onset and unilateral or bilateral symptoms may help determine etiology.
Case Description:
A 46-year-old woman with basilar invagination, atlantoaxial dislocation, immune system problems, and long-term hormone and immunosuppressant use. After a posterior occipital-cervical fusion under general anesthesia, the patient reported bilateral hearing loss and slurring 9 h later. A better MRI scan suggested a fresh brain infarct and increased pure tone audiometry revealed binaural SNHL. Anticoagulation, bacitracin, hyperbaric oxygen, and other symptomatic treatments improved the patient's hearing without affecting daily living. Following the treatment, the patient noted improved hearing, enabling her to talk at a normal distance and volume.
Conclusions
Hyperbolic oxygen and intravenous hormones may cure SNHL, a rare post-surgical spine surgery complication with different infections. Timing and symptoms are crucial for treatment and prognosis.
Real-life Experience With AcrySof® IQ Vivity® Intraocular Lens Implant: Functional Outcomes and Quality of Life
Authors: Giannuzzi Federico , Carlà Matteo Mario , Margollicci Fabio , Stefano Gaetano , Molle Andrea , Hu Lorenzo , Boselli Francesco , Pagliara Monica Maria , Lepore Domenico , Molle Fernando , Rizzo Stanislao 
Published: February 2024

Abstract

Purpose
The extended depth-of-focus AcrySof® IQ Vivity® intraocular lens technology offers promising features for presbyopia management, evaluated in this research in a 6 months real-world setting.
Methods
Prospective interventional mono-centric study including 40 patients who underwent elective bilateral phacoemulsification. We performed one pre-operative visit (V0) and one evaluation six months post-operatively, evaluating uncorrected and corrected visual acuity for near (UNVA/CNVA), intermediate (UIVA/CIVA) and far (UDVA/UCVA), slit-lamp evaluation, tomography with dynamic pupillometry, endothelial cell count and contrast sensitivity chart. In order to assess post-operative Quality of Life, we administered the patients McAlinden's Quality of Vision test and Morlock's Patient-Reported Spectacle Independence Questionnaire.
Results
Mean UDVA significantly improved to 0,04 ± 0,06 LogMar (p = 0.0001), while binocular UDVA was 0,00 ± 0,03 LogMar. For intermediate vision, binocular UIVA was 0.20 ± 0.10 LogMar at 80 cm and 0.30 ± 0.16 LogMar at 60 cm. At 40 cm, monocular and binocular UNVA were 0.52 ± 0.19 LogMar and 0.41 ± 0.16 LogMAR, respectively. Sixty-percent of eyes reached 0,00 LogMar for near vision with an addition of 1,00 D. Overall, 38 (95%) patients had a mean contrast sensitivity value ≥ 1,7 log. Twenty-one (53%) patients reported total independence from their glasses at all distances. The mean difference between the predicted and actual refractive error, as calculated by spherical equivalent, was 0,09 D.
Conclusions
AcrySof® IQ Vivity® is a well-tolerated and effective IOL with optimal refractive target for both distant and intermediate vision, needing slight spherical addition for the best near vision. Great questionnaire-based satisfaction was reported by the patients.
The role of work location in associations between need satisfaction and well-being at work: a daily diary design among Dutch office workers
Authors: Peijen Roy , Niks Irene M.W. , Zwieten Marianne H.J. van , Hengel Karen M. Oude , Wiezer Noortje 
Published: February 2024

Abstract
Background After a quick rise of remote work during the COVID-19 pandemic, hybrid working (i.e., remote and on-site) is becoming common post-pandemic. This study aimed to investigate to what extent work location (i.e., office or home) affects daily associations between psychological need satisfaction (i.e., perceived relatedness and autonomy) and well-being of office workers (i.e., perceived stress and work pleasure).
Methods A daily diary study design with ecological momentary assessments (EMA) was used to investigate day-level relations between work location, need satisfaction, and employee well-being outcomes among 201 Dutch office workers. Measurements took place at the end of each working day (Mondays through Fridays) every month’s first week for three consecutive months. In total, we collected 1,448 daily observations of 201 employees. Multilevel regression models are performed to observe the relationship between daily relatedness and daily autonomy on the one hand and their relationship with both daily work pleasure and daily work stress on the other. Additionally, we explored whether work location serves as a moderator in these relationships.
Results Employees reported more relatedness but less autonomy on office days compared to the days they were working from home. When participants experienced higher daily levels of relatedness or autonomy, they experienced more work pleasure and less work stress. On office days, associations between relatedness and well-being outcomes were stronger than on home working days. Associations between autonomy and well-being did not differ based on work location.
Conclusions This study shows that daily work location may be an important factor to consider in the context of (enhancing) daily need satisfaction and daily employee well-being. Both working at home and working at the office can contribute to daily need satisfaction and employee well-being. It seems particularly important that working in the office is organized in a way that employees are able to make meaningful connections with others.
Analysis of food system drivers of deforestation highlights foreign investments and urbanization as threats to tropical forests
Authors: Sylvester Janelle Marie , Gutiérrez-Zapata Diana María , Pérez‑Marulanda Lisset , Vanegas-Cubillos Martha , Bruun Thilde Bech , Mertz Ole , Castro-Nunez Augusto 
Published: February 2024

Abstract

According to the latest Global Forest Resources Assessment, approximately 90% of global forest cover changes between 2000 and 2018 was attributable to agricultural expansion, positioning food production as the greatest direct driver of deforestation. Our understanding of direct and underlying drivers of deforestation has generally been informed by land systems studies focusing on how interactions between human and environmental systems influence land use change. Yet, despite the prominent role of agricultural expansion for food production in driving deforestation, limited research has explored deforestation through the lens of the food system. Consequentially, little is known about which dimensions of the food system are most influential in driving emissions from deforestation, which in turn impedes the development of effective strategies and policies to reduce food system emissions while achieving zero hunger. Therefore, this study takes a food system approach to analyzing drivers of deforestation at global and continental scales to determine how drivers related to the three dimensions of the food system – (1) consumption/demand, (2) production/supply and (3) trade/distribution – influenced forest cover changes in 40 tropical countries from 2004 to 2021. Results of Extreme Gradient Boosting (XGBoost) models suggest that trade- and demand-side dynamics, namely foreign direct investments and urban population growth, are playing important roles in influencing deforestation trends at the global, Asia and Latin America scales, suggesting that food system-based interventions could be effective in reducing deforestation in these regions. The model for Africa yielded a weaker explanatory power, suggesting factors beyond the food system might have a more substantial impact on deforestation in the region. The proposed framework provides critical insights into where interventions within the food system are needed to reduce deforestation and how such interventions could contribute synergistically to the achievement of coupled sustainable goals, such as climate action, life on land and zero hunger.
Structure-Activity Relationship (SAR) Study of Rigid Guanidine and Guanidino-mimetic Analogues of the Neuropeptide FF Receptor Antagonist MES304
Authors: Galal Kareem , Mottinelli Marco , Mesangeau Christophe , Gupta Sampa , McCurdy Christopher , Mollereau Catherine 
Published: February 2024

Abstract
The Neuropeptide FF (NPFF) receptor system has been implicated in mediating opioid-induced hyperalgesia and tolerance. Understanding the structural features that contribute to high binding affinity of ligands to the NPFF receptors could help in identifying potent and selective NPFF-R probes. We conducted a structure-activity relationship (SAR) study targeting the guanidine functionality of our previously identified lead molecule MES304 in order to probe the guanidine binding site of the NPFF receptors. By applying several rigidifying modifications and substitutions on the guanidine moiety, we concluded that while the guanidine group is optimal for strong binding affinity at both receptor subtypes (NPFF1-R/NPFF2-R), other groups may be tolerated. Compound 17b, in which the guanidine was replaced with a piperidine ring, displayed robust binding affinity at both receptor subtypes (Ki < 300 nM) despite lacking a guanidine group. This indicated that strong binding to the NPFF receptors can be achieved with analogues devoid of guanidine.
Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins
Authors: Dyshlovoy Sergey A. , Mansour Wael Y. , Ramm Natalia A. , Hauschild Jessica , Zhidkov Maxim E. , Kriegs Malte , Zielinski Alexandra , Hoffer Konstantin , Busenbender Tobias , Glumakova Ksenia A. , Spirin Pavel V. , Prassolov Vladimir S. , Tilki Derya , Graefen Markus , Bokemeyer Carsten , Amsberg Gunhild 
Published: February 2024

Abstract
Fascaplysin is a red cytotoxic pigment with anticancer properties isolated from the marine sponge Fascaplysinopsis sp.. Recently, structure-activity relationship analysis reported by our group suggested that selective cytotoxicity of fascaplysin derivatives towards tumor cells negatively correlates with their ability to intercalate into DNA. To validate this hypothesis, we synthesized 6- and 7-tert-butylfascaplysins which reveal mitigated DNA-intercalating properties. These derivatives were found to be strongly cytotoxic to drug-resistant human prostate cancer cells, albeit did not demonstrate improved selectivity towards cancer cells when compared to fascaplysin. At the same time, kinome analysis suggested an activation of CHK1/ATR axis in cancer cells shortly after the drug exposure. Further experiments revealed induction of replication stress that is eventually converted to the toxic DNA double-strand breaks, resulting in caspase-independent apoptosis-like cell death. Our observations highlight new DNA-targeting effect of some fascaplysin derivatives and indicate more complex structure-activity relationships within the fascaplysin family, suggesting that cytotoxicity and selectivity of these alkaloids are influenced by multiple factors. Furthermore, combination with clinically-approved inhibitors of ATR/CHK1 as well as testing in tumors particularly sensitive to the DNA damage should be considered in further studies.
Outcomes of lower extremities Tuberculous wounds in diabetic patients in Eastern Sudan-Kassala: A prospective observational study. 1Abdel
Authors: Elnaim Abdel Latif Khalifa , Mohamed Mamoun Magzoub 
Published: February 2024

Abstract

Introduction: The prevalence of both Diabetes Mellitus (DM) and Tuberculosis (TB) is increasing. DM is a risk factor for TB, while TB will adversely affect DM's treatment. The co-infection is more prevalent in TB-endemic areas and among low socioeconomic populations than others.
Methods: This is a cross-sectional prospective observational study conducted at Kassala State in Sudan between March 2012 to March 2022, including 120 diabetic patients with tuberculous infected ulcers. The outcome measures were wound healing, response to anti-tuberculous drugs, and final treatment outcome.
Results: 120 patients participated, majority were males 66.7%, living in rural areas 75.0%, 70.0% were illiterate, have wounds in the foot 66.7% and 60.8% had their wounds healed in less than 60 days for healing. The mean duration of diabetes was 14 years. Age, gender, residence place, BMI, disease duration, hospital stay, and wound site were associated with wound healing, with a P value< 0.05. Gender (P= 0.002), residence (P > 0.001), and hospital stay (P > 0.001) made a significant contribution to the prediction of the duration of wound healing. For the response to anti-TB drugs, site of the wound, AAFB result, ESR level, and severity of PAD, HbA1c level were significant. For the final treatment outcome, residence, site of wound, severity of PAD, and HbA1c level were significant.
Conclusion: Factors affected wound healing were age, gender, residence, BMI, duration of infection, hospital stay, and wound site. For the response to anti-TB drugs and final treatment outcome, site of the wound, AAFB result, ESR level, severity of PAD, and HbA1c level residence, were the factors with significant impact.
“Quality of Life in Epidermolysis Bullosa” and “Epidermolysis Bullosa Burden of Disease”: Italian translation, cultural adaptation, and pilot testing of two disease-specific questionnaires
Authors: Hachem May El , Diociaiuti Andrea , Zambruno Giovanna , Samela Tonia , Ferretti Francesca , Carnevale Claudia , Linertova Renata , Bodemer Christine , Murrell Dédée F. , Abeni Damiano 
Published: February 2024

Abstract

Background
Inherited epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of skin fragility disorders characterized by blister formation following minor trauma. Four major types are distinguished based on the level of cleavage within the skin. Most EB forms present severely disabling cutaneous and systemic signs and symptoms. Management relies on daily time-consuming and distressing topical medications, and symptomatic treatment of systemic findings. Disease manifestations, symptoms, and daily care strongly affect patient and caregiver quality of life (QoL). To date, there are two validated EB-specific questionnaires, the “Quality of Life in Epidermolysis Bullosa” (QOLEB) and the “Epidermolysis Bullosa Burden of Disease” (EB-BoD) for the evaluation of patient and family disease burden, respectively. The aim of our study was to develop an Italian translation of the two questionnaires and to pilot-test them.
Methods
The guidelines for translation and cross-cultural adaptation of health-related QoL measures were followed. Initially, two separate translations were generated for each questionnaire, and subsequently reconciled by an expert committee. This was followed by a back-translation process. The original texts and all translations underwent revision by the expert committee, resulting in definitive versions. The final versions were then tested in a pilot study involving cognitive debriefing in a group of 17 families, representative of all EB major types.
Results
The translation and reconciliation process led to minor changes to obtain semantic/idiomatic/cultural equivalence of the Italian versions with the original ones and to reconcile the questions with the answer options. The cognitive debriefing process showed a good understanding and did not require text modifications.
Conclusions
The Italian versions of the QOLEB and EB-BoD provide valuable tools in everyday clinical practice of reference centers, and they allow the participation in multicenter international real-life observational studies as well as in controlled clinical trials. They enable the identification of disease-specific psychological and socioeconomic challenges for EB patients and their families, guiding targeted interventions to ensure appropriate and timely care.
Correlation of a Graded Step-Test Protocol to the Buffalo Concussion Treadmill Test in Healthy Population
Authors: Collins Demetrius R. , Barta Kristen , Jacobson Kendal 
Published: February 2024

Abstract

Purpose
The aim of this study was to determine if the Step Test Protocol (STP) can achieve a similar trajectory of cardiovascular response in healthy individuals as the Buffalo Concussion Treadmill Test (BCTT). We hypothesized that there would be a significant correlation between heart rate and rate of perceived exertion in healthy individuals between the BCTT and the STP.
Methods
Twenty-two participants (males 9; females 13) individuals, with no previous history of concussion or underlying respiratory, cardiovascular, or musculoskeletal injury, performed both the STP and BCTT in succession. Resting heart rate was measured prior to activity and taken again throughout each exercise test. Rate of perceived exertion was also taken at the end of each stage for each exercise test. The percentage of the age-related predicted maximum heart rate for each stage was calculated and a Pearson correlation was used to calculate the relationship between the tests.
Results
All participants completed stage 5 of the STP and stage 8 of the BCTT. A positive correlation was found between the percentage of age-related predicted maximum heart rate achieved during the STP and BCTT for stages completed by all participants.
Conclusions
The STP produces a similar physiological effect as the BCTT in a healthy population.