bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteome profiling of serum reveals PSMD6 as a biomarker in breast cancer metastasis
Authors: Ding Chen , Meng Yue , Huang Minjing , Xu Ganfei , Li Xinwei , Gu Bing 
Published: December 2023

Abstract

Breast cancer (BC) has the highest mortality rate and prevalence among cancers in females worldwide. Here, we performed proteomic profiling of 322 serum samples from the discovery cohort [56 healthy controls (HCs), 112 benign breast tumor (BBT) patients, and 154 BC patients] and a prospective validation cohort [27 HCs, 29 BBT patients and 57 BC patients]. Integrated proteomic analysis of tissue and serum samples revealed highly specific tumor biomarkers and demonstrated that the serum proteome can distinguish the different pathological substages in BC progression. We also identified PSMD6 as a potential metastatic breast cancer (MBC) biomarker. Comprehensive analysis of the multicenter independent validation cohort, which included retrospective and prospective cohorts including 61 HCs, 72 BBT patients, and 247 BC patients, indicated that PSMD6 overexpression was an important cause of BC metastasis and an indicator of poor prognosis. Further study revealed that the CLTA-PSMD6-neutrophil axis promotes the transition from invasive ductal carcinoma (IDC) to MBC. Importantly, CLTA amplification might be a potential therapeutic target for MBC patients. We also developed a highly accurate predictive model (accuracy = 0.87) to differentiate benign and malignant tumors and validated its good performance in the prospective validation cohort. Collectively, this study demonstrates the elaborate BC serum proteomic landscape and provides valuable information regarding serum biomarkers, which could reveal novel therapeutic targets and provide opportunities for MBC treatment.
Corporate lobbying and its implications for global food governance: mapping and analysing the global corporate influence network of the transnational ultra-processed food industry
Authors: Slater Scott , Lawrence Mark , Wood Benjamin , Serodio Paulo , Baker Phillip 
Published: December 2023

Abstract
Background
A major challenge to transforming food systems to promote human health and sustainable development is the global rise in the manufacture and consumption of ultra-processed foods (UPFs). A key driver of this dietary transition is the globalization of UPF corporations, and their organized corporate political activity (CPA) intended to counter opposition and block government regulation. UPF industry CPA and the corporate interest groups who lobby on their behalf have been well described at the national level, however, at the global level, this network has not been systematically characterized. This study aims to map, analyse, and describe this network, and discuss the implications for global food policy action on UPFs, global food governance (GFG), and food systems transformation.
Methods
We conducted a network analysis of the declared interest group memberships of the world's leading UPF corporations, extracted from web sources, company reports, and relevant academic and grey literature. Data on the characteristics of these interest groups were further extracted for analysis, including year founded, level, type, and headquarter location.
Results
We identified 268 interest groups affiliated with the UPF industry. The UPF manufacturers Nestlé (n = 171), The Coca-Cola Company (n = 147), Unilever (n = 142), PepsiCo (n = 138), and Danone (n = 113) had the greatest number of memberships, indicating strong centrality in coordinating the network. We found that this network operates at all levels, yet key actors now predominantly coordinate globally through multistakeholder channels in GFG. The most common interest group types were sustainability/corporate social responsibility/multistakeholder initiatives, followed by branding and advertising, and food manufacturing and retail. Most corporate interest groups are headquartered where they can access powerful government and GFG decision-makers, nearly one-third in Washington DC and Brussels, and the rest in capital cities of major national markets for UPFs.
Conclusions
The UPF industry, and especially its leading corporations, coordinate a global network of interest groups spanning multiple levels, jurisdictions, and governance spaces. This represents a major structural feature of global food and health governance systems, which arguably poses major challenges for actions to attenuate the harms of UPFs, and to realising of healthy and sustainable food systems.
A novel feature dimensionality reduction method for gearbox fault diagnosis with HMSDE, DANCo-DDMA and KELM
Authors: Huang Peng , Gu Yingkui , Qiu Guangqi 
Published: December 2023

Abstract

This paper proposes a gearbox fault diagnosis method with HMSDE, DANCo-DDMA and AOA-KELM. Firstly, the raw HMSDE features are extracted from the raw time domain signals, then, the intrinsic dimension of the HMSDE features is estimated by DANCo, and the extracted HMSDE features are dimensionality reduction by DDMA for eliminating the redundant information. Finally, AOA-KELM is used to classify the reduced HMSDE features. Two experiments are used for verifying the effectiveness and practicality of the proposed gearbox fault diagnosis method, and the results showed that the HMSDE feature has exhibited better characterization performance for the operating state and real behavior of the mechanical system compared with MMSDE, HSDE, and RCMSDE. The AOA-KELM classifier has reached 100% classification accuracy by inputting the reduced HMSDE features, and has achieved a maximum classification accuracy with a minimum fluctuation among LSSVM, RF, KNN, and SOF classifiers, indicating that the proposed method is effectively realized the gearbox fault diagnosis under different working conditions.
Complete uterine rupture in the second trimester of pregnancy and covered by greater omentum to stop bleeding：a case report
Authors: Huang Jia-Zhen , Sun Hai-Yan 
Published: December 2023

Abstract

Background: Uterine rupture usually occurs during delivery, acompany with abnormal fetal heart rate, acute blood loss and hemorrhagic shock. But in our case, the rupture happened on the 20th weeks, the location of uterine rupture was not at common surgical incision, and because of the rupture was covered by the greater omentum, the patient didn’t have severe tearing pain, hypovolemic shock, significant decrease in hemoglobin, vaginal bleeding, and normal fetal heart rate. It was a situation that was easy to miss diagnosis and cause serious maternal complications.
Case presentation: A 24-year-old G2C1 pregnant woman was admitted to our hospital due to "20 + 5 weeks of menopause, epigastric and right lower abdominal pain with nausea and vomiting for 6 days". The patient underwent laparoscopic exploration, and During the laparoscopic exploration: the appendix, intestine, spleen, ovary and other abdominal organs were normal, we only found the fundus of the uterus was adherent to the greater omentum, and the remaining uterus was smooth. Only by decisively separating the greater omentum from the position of close adhesion with the uterus can the rupture be seen. After separating, the amniotic sac ruptured naturally, a male stillborn fetus was delivered through the rupture and we suture the rupture.
Conclusions: For the first and second trimester of pregnancy, abdominal pain is the only major clinical symptom of uterine rupture, and the pain is non-specific, starting a few hours to a few days before the diagnosis. Uterine rupture usually happens after uterine surgery, placental implantation, improper use of uterine contraction drugs, and obstetric surgical procedures. These suggest that uterine rupture should be considered in the diagnosis of all pregnant women with acute abdomen pain. The greater omentum as a source of resident inflammatory cells and stem cells that can be used to participate in the local control of infection, wound healing, and tissue regeneration. If patients’ symptom is untypical, we should take attention to the greater omentum’s influences.
De novo inverse materials design by combining optimization algorithm, universal potential and universal property model
Authors: Yin Wan-Jian , Cheng Guanjian , Gong Xin-Gao 
Published: December 2023

Abstract
We present a de novo inverse materials design (DNID) approach that fully automates the materials design for target physical properties, without the need to provide atomic composition, chemical stoichiometry, and crystal structure in advance. Here we used density functional theory reference data to train a universal machine learning potential (UPot), and transfer learning to train a universal bulk modulus model (UBMod). Both UPot and UBMod were able to cover materials systems composed of any elements among 42 elements. Interfaced with optimization algorithm and enhanced sampling, the DNID is applied to find the materials with the largest cohesive energy and the largest bulk modulus, respectively. NaCl-type ZrC was found to be the material with the largest cohesive energy and many other new materials were discovered to have the strong atomic cohesion, such as C, TiC, and ZrO2. For bulk modulus, diamond was identified to have the largest value and many other new carbon prototypes, several carbon borides and carbon nitrides were found to have large bulk modulus close to diamond. The DNID approach is applicable to design the materials with other multi-objective properties with accuracy limited principally by the amount, reliability and diversity of the training data. It provides a new way for the inverse materials design with other functional properties for practical applications.
Physical and Structural Characterization of Bis-Acryl Composite Resin
Authors: Guardado Wendy E. Rodríguez , Muñoz Eric M. Rivera , Bello Janeth Serrano , Pérez Marco A. Álvarez , Pérez Ruben A. Domínguez , Valdés Elias Nahum Salmerón , Vázquez Febe C. Vázquez , Cuevas Osmar A. Chanes , Malo Beatriz Millán , Ledesma Carmen Leticia Peza , Prado Rodrigo Correa 
Published: December 2023

Abstract
Objective
To determine if the chemical and structural characteristics could cause to increase the fracture resistance using four bis-acryl resins Luxatemp, Protemp, Structur and Telio.
Materials and Methods
Three-points bending by Flexural test, SEM, and FTIR were carried out to compare the Kruskal-Wallis test.
Results
The Kruskal-Wallis test indicated a significant difference in the materials (< 0.0001) that showed higher flexural strength found in Luxatemp, while comparing all bis-acryl resins by Dunn's multiple comparison test indicate that there was no significant difference between Luxatemp VS Structur, and Protemp VS Telio. SEM analysis showed that different sizes of filler particles were observed in all samples, which causes them to present irregular surfaces. By FTIR, typical C = O and CH2 groups were observed corresponding to methyl methacrylate and methylene groups respectively, and different bands located at 1460 − 1350 cm− 1 assigned to pigment materials, stabilizers, and filler particles. In conclusion, a long cross-linkage polymer chain, and the presence of CO3, SiO2 and N-H groups as a fillers particle interacting with OH groups could be the cause of our results.
Conclusion
It is necessary a longer storage under a different condition that would emulate the oral environment and allow us to determine changes in the chemical compounds as well as changes in ultrastructural characteristics related to mechanical properties to identify their correct clinical use.
Clinical Relevance
During the preparation of fixed prosthesis (including individual bridges and crowns) it is important to select the materials that have the best features and properties to predict a successful clinical treatment.
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
Authors: Miyazaki Haruko , Ikawa Masahito , Nukina Nobuyuki , Nishioka Saki , Yamanaka Tomoyuki , Abe Manabu , Imamura Yukio , Miyasaka Tomohiro , Kakuda Nobuto , Oohashi Toshitaka , Shimogori Tomomi , Yamakawa Kazuhiro 
Published: December 2023

Abstract

Golli–myelin basic proteins, produced by the myelin basic protein gene, are widely expressed in the neurons and oligodendrocytes of the central nervous system. Previous reports have shown that Golli–myelin basic protein is necessary for myelination and neuronal maturation during central nervous system development. In this study, we established Golli–myelin basic proteins–floxed mice to elucidate the cell-type-specific effect of Golli–myelin basic proteins knockout–generated conditional knockout mice (Golli–myelin basic proteinsfl/fl; E3CreN), in which Golli–myelin basic proteins was specifically deleted in the cerebellar granule neurons, where abundant Golli–myelin basic proteins were expressed in wild-type mice. To investigate the role of Golli–myelin basic proteins in cerebellar granule neurons, we performed a pathohistological analysis using Golli–myelin basic proteinsfl/fl; E3CreN mice. However, they did not show any morphological changes or degeneration of the major cellular components of the cerebellum. Furthermore, behavioral analysis showed that Golli–myelin basic proteinsfl/fl; E3CreN mice were healthy and did not display any abnormal behavior. These results suggested that the loss of Golli–myelin basic proteins in cerebellar granule neurons does not lead to cerebellar perturbations or behavioral abnormalities. This mouse model could be employed to analyze the effect of Golli–myelin basic proteins deletion in specific cells of the central nervous system and other cell types expressing Golli–myelin basic proteins, such as those of the immune system.
Thermally Stimulated Transformation of Oxygen Atoms between Phase States in a Silicon Single Crystal
Authors: Kalanov M. U. , Sadikov I. I. , Khugaev A. V. , Malikov Sh. R. , Saidov A. S. , Usmanov Sh. N. , Saparov D. V. 
Published: December 2023

Abstract
The high-temperature X-ray diffraction method showed the presence of two phase states of oxygen in the volume of a single crystal of silicon grown by the Czochralski method: a dissolved (interstitial) state in the composition of “quasimolecules” - SiO2 and a chemically bound (precipitate) state in the composition of silicon dioxide - SiO2; the precipitate state of oxygen in the bulk of silicon is in the form of crystalline SiO2(c), and in the near-surface layer of a single crystal in the amorphous form of SiO2(a). The thermally stimulated transformation of oxygen atoms between dissolved and precipitate states of oxygen in crystalline form in the bulk of a silicon single crystal has been established.
Latitude-driven functional trait variations in Zizania latifolia: insights into climate adaptation
Authors: Jiang Hong Sheng , Fan Xiangrong , Wagutu Godfrey Kinyori , Wang Wuchao , Li Wei , Chen Yuanyuan 
Published: December 2023

Abstract
Background
Global warming could have a significant impact on plant adaptation to local environments. Widespread species provide a useful model to examine the population dynamic under climate change. However, it is still unclear how widespread aquatic species respond to rapidly changing environments. Wild-rice Zizania latifolia is an emergent macrophyte widely distributed across East Asia. Here, 28 Z. latifolia natural populations covering above 30 latitudes were transplanted in a common garden.
Results
The growth, photosynthesis and reproduction traits were quantified and compared among populations, and pairwise relationships among geographic, genetic and growth traits were estimated. Results showed that, in the common garden, the high-latitude populations grew in small size indicating weaker competitiveness in warmer temperatures; the low-latitude populations had no sexual reproduction, suggesting that low-latitude individuals stood little chance to migrate successfully to higher latitude. Significantly positive correlations among the distances of genetic, geographic and biological traits for populations indicated that both isolation by distance and isolation by environment models affected the genetic pattern of populations, and phenotypic traits of Z. latifolia populations might be determined genetically.
Conclusions
All our results suggested that, despite widespread, the genetically determined differentiation of Z. latifolia populations causing growth and reproduction traits could not rapidly acclimate to the accelerated increase of temperature, which implies this widespread species could fail to cope with global warming via migration.
Multiple Cystic Brain Infection: A Diagnostic Dilemma of Neurocysticercosis and Intracranial Tuberculoma - Case report
Authors: Chew JX , Tan JK , Ho WC , Arifin NM , Chinnasami S , Amran MH , Lim KC , Kamaludeen S 
Published: December 2023

Abstract

Background: Neurocysticercosis (NCC) is a central nervous system infection caused by Taenia solium, or pork tapeworm, affecting millions worldwide and possibly represents a leading cause of epilepsy in developing countries. NCC may be challenging to distinguish from intracranial tuberculomas, with tuberculosis highly prevalent in developing countries. We highlight the importance of clinical history, including exposure history and neuroimaging, in obtaining an accurate diagnosis to enable prompt treatment.
Case presentation: This case illustrates a 26-year-old gentleman diagnosed with NCC presenting with acute giddiness and headache. Clinical history suggested ingestion of undercooked pork, absence of constitutional symptoms, and neuroimaging demonstrated cerebral lesions with scolex and multiple lesions less than 2cm in diameter on brain MRI. He recovered well following a combination of oral albendazole and praziquantel, with corticosteroids prescribed as adjunct.
Conclusion:
This case highlights the salient features to distinguish NCC from intracranial tuberculoma. Early, accurate diagnosis will enable patients to obtain correct treatment and expedite recovery.
pH-responsive Nanosystems for Targeted Drug Delivery to Glioblastoma Multiforme and MRI-facilitated Monitoring of Content Release
Authors: Mundžić Mirjana , Ultimo Amelia , Lazović Jelena , Mladenović Minja , Pavlović Aleksandra , Gobbo Oliviero , Ruiz-Hernandez Eduardo , Santos-Martinez Maria , Knežević Nikola 
Published: December 2023

Abstract
Despite the current state-of-the-art glioblastoma treatment options, a clear indication of therapeutic delivery and efficacy is still missing, especially in early therapy. Substantial advancements, particularly in the areas of image-guided and targeted therapy of the most aggressive type of brain cancer-Glioblastoma multiforme (GBM), are needed to improve the quality of life and survival rates of patients. Herein we describe a proof of principle study toward developing a novel methodology for non-invasive monitoring of the release of cargo molecules from theranostic nanoparticles. This is achieved by quantifying changes in longitudinal relaxation time (T1) before and after the pH-responsive release of contrast agents for magnetic resonance imaging (MRI), from the pores of GBM-targeted mesoporous silica nanoparticles (MSNs). The pores of MSNs were loaded either with the anticancer drug paclitaxel (PTX) or FDA-approved contrast agent Gadobutrol, and their retention inside the pores was ensured by covalent attachment of β-cyclodextrin monoaldehyde to hydrazine-functionalized MSN, through acidification-cleavable hydrazone linkage. In vitro studies using a GBM cell line revealed that the developed nanoparticles effectively delivered their therapeutic cargo, leading to cell death, which was further enhanced with additional functionalization of MSNs with glioma-homing oligopeptide chlorotoxin (CHX). Furthermore, the changes in T1, occurring in response to the release of GdB from the pores of MSNs were successfully demonstrated by MRI measurements. These results are promising for the development of MRI-based methodology for monitoring and tracking the release of therapeutic content in tumor tissues. It is envisioned that this approach using contrast agent-loaded nanoparticles, before the treatment with the drug-filled analogues, could be applied in the future to provide increasingly personalized clinical management of cancer patients.
Current Status, Challenges, and Future Career Pathways of Diploma-Prepared Nurses from the Stakeholders’ Perspective: A Qualitative Study
Authors: Nasser Seema 
Published: December 2023

Abstract

Background
Researchers have examined the nursing profession in Saudi Arabia and the Kingdom 2030 Vision and highlighted that several issues challenge the nursing profession in Saudi Arabia in terms of nursing shortages, underdeveloped nursing education, and undistinguishable scope of practice. It was highlighted that when viewed within the context of 2030, it is thus clear that there is an urgent demand for policy maker to improve nursing care in Saudi Arabia by attending to the nursing shortage, generating strategies to enhance nursing education, and establishing the scope of practice guidelines. Therefore, retention of diploma-prepared nurses is an urgent matter as well, with the notion of the vast numbers in the nursing workforce. Although the experiences of diploma-prepared nurses have been described in the literature, there is a lack of evidence to support the job career paths for nurses and the retention of diploma nurses in Saudi Arabia. Understanding the current challenges and future trends, and solutions from the stakeholders’ perspective is a critical first step that will retain diploma-prepared nurses in the profession and ultimately lead policymakers to formulate policies to address these issues.
Objective
to generate an empirically derived substantive framework to overcome challenges and develop tailored career pathways for diploma-prepared Nurses from the stakeholders’ perspective.
Methods
Thematic analysis qualitative study and grounded theory method will be employed to produce a detailed description and theoretical analysis of the challenges and future of diploma-prepared nurses.
Results
Several themes emerged, and results generated an empirically derived substantive framework to overcome challenges and develop tailored career pathways for diploma-prepared Nurses from the stakeholders’ perspective.
Conclusion
The generated framework will indirectly enhance the delivery of quality healthcare, as it will stimulate the development and implementation of career path programs to promote a better quality of healthcare delivery for patients.
PCSK9 inhibitors attenuates arterial stiffness in patients with acute coronary syndrome
Authors: Wang Liang , Wang Ruijie , Jiao Tiantian , Xu Linghao , Ji Endong , Jiang Yuanzhen , Wang Yuanqi , Liu Yehong , Li Jiming 
Published: December 2023

Abstract

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors has been demonstrated to exert a great protection in acute coronary syndrome (ACS) with atherosclerosis. However, the effect of these drugs on vascular function, such as arterial stiffness (AS), has not been extensively described yet.
OBJECTIVE: This study focuses on uncovering the actions of PCSK9 inhibitors on attenuates AS.
METHODS: The experiment was randomly divided into 2 groups, one treated with statin and PCSK9 inhibitors (Evolocumab or Alirocumab) and the other with statin alone. Detected the indicators of lipid metabolism and AS were at the beginning of treatment, 1 month and 6 months after treatment.
RESULTS: With 1 month treatment of statin and PCSK9 inhibitors, the levels of LVEF, NTP, TC, TG, LDL, Lp(a) in the patients had reduced already more apparently than only with statins. Until 6 months follow-up, pulse wave velocity had improved notably (p-value＜0.05), and ankle brachial index had also decreased significantly undergoing treatment with statins and PCSK9 inhibitors (p-value＜0.05), no differ significantly by Evolocumab or Alirocumab (p-value＞0.05).
CONCLUSIONS: In summary, this research suggested that PCSK9 inhibitors can not only improve lipid metabolism, but also attenuate AS, which give a further rationale for using PCSK9 inhibitors for its effect in vascular disorders.