bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 5-D memristive hyperchaotic system with extreme multistability and its application in image encryption
Authors: Dong Qianqian , Bai Yulong , Zhu Kailing 
Published: February 2024

Abstract
By coupling memristors to nonlinear circuits, more complex dynamical behaviors can be induced. However, to date, there has been insufficient attention given to high-dimensional chaotic systems based on memristors. In this paper, a magnetic-controlled memristor is combined with a three-dimensional chaotic system, resulting in a five-dimensional memristive chaotic system. Through dynamic analysis and numerical simulations, the chaotic nature of the system is elucidated based on fundamental system behaviors, including Lyapunov dimension, dissipativity, stability of equilibrium points, 0–1 test, and Poincaré mapping. During the complex dynamical analysis of this system, unique dynamical behaviors are discovered, including intermittent chaos, transient chaos, extreme multistability, and offset-boosting. Moreover, the consistency between numerical calculations and the physical implementation of the actual system is verified through equivalent circuit design. Finally, this system is applied to image encryption, leading to the design of an efficient and secure hyper-chaotic image encryption algorithm, whose effectiveness is confirmed through several security tests.
Development of water-cooled cylindrical blanket in JA DEMO
Authors: Youji Someya , Hiroyasu Tanigawa , Yoshiteru Sakamoto ,   the Joint Special Design Team for Fusion DEMO
Published: February 2024

Abstract
The concept of the tritium breeding blanket for Japan’s DEMOnstration fusion reactor (JA DEMO) has been developed with pressure tightness against in-box loss-of-coolant accidents based on a water-cooled solid breeder concept. The cooling conditions are designed on the pressurized-water reactor water conditions which are the coolant temperature of 290 °C–325 °C and the operating pressure of 15.5 MPa, respectively. The point of the blanket design is to reduce the amount of structural material in casing as well as to ensure its pressure tightness. This is because a decrease in the amount of structural material improves tritium breeding ratio (TBR). A cylindrical structure, a thin wall casing structure which ensures pressure tightness and could increase TBR, is feasible. However, a relatively larger useless space is expected between modules when the cylindrical blanket modules are arranged in a vacuum vessel, which could decrease TBR. Therefore, the cylindrical blanket modules are to be in a close-packed arrangement to reduce useless space. The Be12Ti block (which shows a minor swelling compared to Be) is selected to achieve the target TBR as the net Be density is equivalent to the case of the Be pebble. The use of Be12Ti blocks can reduce or remove the cooling piping inside the module as the Be12Ti block has a higher thermal conductivity than pebbles. As a result of the neutronics, finite element method, and computational fluid dynamics analyses, it was found that the target TBR value can be achieved in cylindrical structure blanket that ensure pressure tightness.
Airbag injuries of the hand: a case-series and literature review
Authors: Mahmoud Asmaa Z B , Alhusain Abdullah M , Alkhadhrawi Mohammed N H , Vasilescu Dana C 
Published: February 2024

Abstract
Motor vehicle accidents are a significant cause of morbidity and mortality worldwide. Airbags aim to reduce the severity of motor vehicle accidents, but their deployment is not without risks. This study presents five cases presenting with diverse forms of upper extremity injuries following airbag deployment. The presented cases highlight the variety of clinical presentations, the differences in diagnostics in terms of imaging modalities, as well as the spectrum of possible outcomes from complete healing to decreased range of motion to persistent neurological symptoms. Understanding the mechanisms and presentations of such injuries can only help in improving and creating new strategies for the prevention of such injuries, as well as their management.
Assessment and Recommendations for Website Platforms of Neuroanesthesiology Fellowship Programs
Authors: Zhitny Vladislav P. , Do Kenny , Kawana Eric , Do Jenifer , Wajda Michael C. , Gallegos Jose , Carey Kyle , Yee Geoff , Hollifield Lauren C. , Montes Arturo , Walton Edward , Ahmed Shah 
Published: February 2024

Background:
Websites serve as recruitment and educational tools for many fellowship programs, including neuroanesthesiology. Since the COVID-19 pandemic, when interviews, conferences, and institutional visits were moved online, websites have become more important for applicants when deciding on their preferred fellowship program. This study evaluated the content of the websites of neuroanesthesiology fellowship programs.

Methods:
Neuroanesthesiology fellowship program websites were identified from the websites of the International Council on Perioperative Neuroscience Training and the Society for Neuroscience in Anesthesiology and Critical Care. The content was assessed against 24 predefined criteria.

Results:
Fifty-three fellowship programs were identified, of which 42 websites were accessible through a Google search and available for evaluation. The mean number of criteria met by the 42 fellowship websites was 12/24 (50%), with a range of 6 to 18 criteria. None of the evaluated fellowship websites met all 24 predefined criteria; 20 included more than 50% of the criteria, whereas 7 included fewer than 30% of the criteria. Having a functional website, accessibility through a single click from Google, and a detailed description of the fellowship program were the features of most websites. Information about salary and life in the area, concise program summaries, and biographical information of past and current fellows were missing from a majority of websites.

Conclusion:
Important information was missing from most of the 42 evaluated neuroanesthesiology fellowship program websites, potentially hindering applicants from making informed choices about their career plans.
The Use of Silver Oxynitrate Wound Dressings in the Treatment of Chronic Wounds: A Feasibility Pilot Study
Authors: Rodriguez-Arguello Jimena , Lienhard Karin , De Grood Jill , Geransar Rose , Somayaji Ranjani , Khan Daniyal , Conly John , Ho Chester , Parsons Laurie 
Published: February 2024

ABSTRACT

OBJECTIVE
To evaluate the feasibility and effectiveness of a silver oxynitrate (Ag7NO11) dressing on wound healing in patients with stalled chronic wounds.

METHODS
A prospective pilot study was conducted to determine the feasibility and effect of using silver oxynitrate dressings within an outpatient setting in Alberta, Canada. A total of 23 patients (12 women and 11 men; mean age, 66.1 ± 13.8 years) with a chronic wound that failed to heal with conventional treatment were included in the study. Wound assessments including the Bates-Jensen Wound Assessment Tool, wound-related pain, wound size, and patient quality of life (QoL) were conducted at baseline, after dressing application for 1 and 2 weeks, and during 4- and 12-week follow-ups.

RESULTS
Dressing application at 1 and 2 weeks improved patients’ wound healing progression as measured through significantly decreased Bates-Jensen Wound Assessment Tool scores with a more than 10% decrease at 4- and 12-week follow-up (P < .001). Pain (P = .004), and QoL psyche subscore (P = .008) significantly improved at 4-week follow-ups, although wound area, perimeter, and QoL body and everyday subscores were not significantly affected. Wound size was not significantly affected.

CONCLUSIONS
The silver oxynitrate dressing may improve healing progression in patients with chronic wounds, enhance patient experience by reducing wound-related pain, and improve patients’ mental well-being. Further studies are warranted to elucidate the effect of silver oxynitrate dressings on wound area, perimeter, and volume measurements.
Various Therapies for Lymphedema and Chronic Venous Insufficiency, Including a Multimodal At-Home Nonpneumatic Compression Treatment
Authors: Barnhart Heather , Maldonado Thomas , Rockson Stanley G. 
Published: February 2024

ABSTRACT
Lymphedema and chronic venous insufficiency (CVI) affect millions of people and require lifelong management. Many compression options exist for the long-term management of these conditions; however, limitations in patient mobility and adherence are common. Current options for care often present challenges with adherence because they are time-intensive and cumbersome. Innovation is needed to improve compression options for patients with chronic edematous conditions, particularly because lymphedema and CVI benefit from combination interventions. In this narrative review, the authors focus on long-term management strategies for lymphedema and CVI and highlight a nonpneumatic compression device designed for ease of use in the management of lymphedema and CVI. Using a nonpneumatic compression device that combines multiple treatment modalities demonstrates improved efficacy, quality of life, and patient adherence.
Association Between Hearing Loss, Asymmetric Hearing, and Postural Instability
Authors: Wang Yang , Zhong Mei , Li Yifan , Liu Yehai , Tong Busheng , Qiu Jianxin , Chen Shanwen 
Published: February 2024

Objectives:Recent studies have suggested that older adults with hearing loss (HL) are at a greater risk of postural instability than those with normal hearing. However, little is known regarding this association in middle-aged individuals. The relationships between HL laterality, asymmetric hearing, and posture control are similarly unclear. The purpose of this study was to investigate the effects of hearing status on postural control and to explore the dose-response relationship between the hearing threshold and postural instability risk in middle-aged adults.Design:This cross-sectional study included 1308 participants aged 40 to 69 years with complete audiometric and standing balance function data from the 2001–2004 National Health and Nutrition Examination Survey. Speech-frequency HL was defined as a pure-tone average at 0.5, 1, 2, and 4 kHz of >25 dB in the better-hearing ear; high-frequency HL was defined as a pure-tone average at 3, 4, and 6 kHz of >25 dB. Asymmetric hearing was defined as a difference in the pure-tone average >15 dB between ears. Postural instability was defined as participants ending the modified Romberg test in condition 4.Results:After adjustment for sociodemographic variables, lifestyle, and comorbidities, speech-frequency HL, except for unilateral HL, was associated with increased postural instability (mild HL: odds ratio [OR], 2.33; 95% confidence interval [CI], 1.25–4.35; moderate-to-severe HL: OR, 3.59; 95% CI, 1.61–8.03). Compared with individuals with normal bilateral hearing, participants with bilateral HL also showed a higher risk of postural instability (OR, 2.88; 95% CI, 1.61–5.14). The OR for postural instability among participants with asymmetric hearing compared with those with symmetric hearing was 2.75 (95% CI, 1.37–5.52). Furthermore, each 10 dB increase in the speech-frequency hearing threshold was associated with a 44% higher risk of postural instability.Conclusions:Hearing loss is associated with poorer postural control. Individuals with asymmetric hearing have a higher postural instability risk compared with those with symmetric hearing. Further studies are needed to confirm these findings and the causality. Moreover, future studies are warranted to assess whether hearing aids are beneficial for the restoration of impaired balance functions.
A Rare Case of Varicella Zoster Infection in Hemorrhoids in a Patient With Inflammatory Bowel Disease
Authors: Siatecka Hanna , Al-Awami Sarah , Siddiqi Ahsan , Diwan A. Hafeez 
Published: February 2024

Abstract:
Hemorrhoids are normal anatomical structures in the anus. When symptomatic, they prompt medical attention due to pain, rectal bleeding, and discomfort. Treatment includes dietary modifications, rubber band ligations, sclerotherapy, cryotherapy, or hemorrhoidectomy. Histologic examination is important to rule out incidental findings, such as perianal intraepithelial neoplasia, anal carcinoma, melanoma, or coexisting infections. Special attention should be given when patient is immunocompromised. We present a case of a 41-year-old man with a history of ulcerative colitis on adalimumab who presented with anal lesions. He was diagnosed with hemorrhoids and surgically treated. Microscopic examination confirmed the diagnosis of hemorrhoids. However, foci of epithelium with viral cytopathic effects were noted. A varicella zoster virus (VZV)-specific immunostain was positive in the areas of interest confirming the diagnosis of the VZV infection limited to the hemorrhoids. Combined herpes simplex virus type 1 and 2 (HSV 1 and HSV 2) immunostain was also performed and was negative. Anal herpes has been widely described in the literature, particularly in immunocompromised patients. However, isolated VZV infection in hemorrhoids to the best of our knowledge has never been reported.
Cutaneous Malignant Mixed Tumor With Pulmonary Metastasis: A Case Report and Literature Review
Authors: Haberecht Hannah , Tekin Burak , Warren Krista , Guo Ruifeng (Ray) 
Published: February 2024

Background:
Cutaneous malignant mixed tumor (MMT) is a rare sweat gland–derived tumor characterized by admixed malignant epithelial cells and chondromyxoid stroma. Approximately 50 cases have been described in the literature. Metastasis, which may occur in more than one-third of cases, is most common in the lung.

Methods:
We summarized the clinicopathologic features of a patient with cutaneous MMT metastatic to the lungs. A literature review of similar cases was completed using Web of Science, Scopus, and PubMed databases.

Results:
A woman in her 70s presented with an enlarging mass on her left eyebrow; histopathologic examination showed large islands of atypical cells with increased mitotic activity, admixed with necrosis on a background of fibrotic and chondromyxoid stroma. Multiple lung nodules were identified during follow-up. Examination of a pulmonary core needle biopsy specimen was consistent with metastatic cutaneous MMT. Literature review identified 10 cases published between 1980 and 2017. Most primary tumors were large (≥4 cm). Local recurrence was uncommon, and the lung was the only metastatic site in 5 cases. Histopathologically, metastatic tumors were described as more cellular, with diminished stromal tissue compared with the primary lesion.

Conclusion:
This is 1 of the 11 reports of cutaneous MMT with metastasis to the lungs found in the English-language literature published after 1980. Of note, most reports were published before 1990, making this case study one of the few contemporary descriptions of cutaneous MMT with pulmonary metastases. We think that the present case report will increase the awareness of this rare tumor.
COVID-19 vaccine-induced liver injury
Authors: Shroff Hersh 
Published: February 2024

Purpose of review
The rapid rollout and uptake of novel coronavirus disease 2019 (COVID-19) vaccines has been accompanied by a small yet noticeable accumulation of reports of liver injury occurring after vaccination. This review describes the present evidence surrounding COVID-19 vaccine-induced liver injury (VILI).

Recent findings
Liver injury occurring after the COVID-19 vaccine often presents clinically similar to autoimmune hepatitis, with positive autoantibodies and a portal and lobular inflammatory infiltrate and varying degrees of necrosis on biopsy. The overwhelming majority of patients recover, often spontaneously or with a limited course of immunosuppression. The overall incidence of this phenomenon appears to be exceedingly low.

Summary
Providers should remain vigilant for ongoing reports of VILI after COVID-19 and yet feel reassured by the low incidence and high likelihood of recovery. Ongoing genetic and histological study, as well as longer-term follow-up of presently identified cases, will shed further light on the clinical entity of VILI.
Terlipressin for hepatorenal syndrome
Authors: Wong Florence 
Published: February 2024

Purpose of review
The definition and diagnostic criteria of hepatorenal syndrome-acute kidney injury (HRS-AKI) has undergone recent changes. A major vasoconstrictor, terlipressin, has recently been approved as pharmacotherapy for HRS-AKI in the United States. The purpose of this review is to familiarize the readers with these new diagnostic criteria of HRS-AKI, and how best to use terlipressin.

Recent findings
Terlipressin is effective either as bolus dosing or continuous infusion and can achieve reversal of HRS-AKI in approximately 40% of patients. Continuous infusion allows lower daily dose with equal efficacy and less side effects but not an approved mode of administration in the United States. Response to terlipressin in the randomized controlled trials was defined as repeat reduction of serum creatinine to less than 1.5 mg/dl. Newer studies will likely require response to treatment to be defined as a repeat serum creatinine to be less than 0.3 mg/dl from baseline. Terlipressin use is associated with ischemic side effects and potential for respiratory failure development.

Summary
Careful patient selection and close monitoring are necessary for its use. Response to terlipressin with HRS-AKI reversal is associated with improved outcomes with better survival and less requirement for renal replacement therapy.
Epidemiology and Clinical Characteristics of Pediatric Sepsis in PICUs in Southwest China: A Prospective Multicenter Study*
Authors: Liu Rong , Yu Zhicai , Xiao Changxue , Xu Feng , Xiao Shufang , He Juan , Shi Yan , Hua Yuanyuan , Zhou Jimin , Zhang Guoying , Wang Tao , Jiang Jianyu , Xiong Daoxue , Chen Yan , Xu Hongbo , Yun Hong , Sun Hui , Pan Tingting , Wang Rui , Zhu Shuangmei , Huang Dong , Liu Yujiang , Hu Yuhang , Ren Xinrui , Shi Mingfang , Song Sizun , Luo Jumei , He Gang , Zhang Juan 
Published: February 2024

OBJECTIVES:To describe the epidemiological characteristics of pediatric sepsis in Southwest China PICUs.DESIGN:A prospective, multicenter, and observational study.SETTING:Twelve PICUs in Southwest China.PATIENTS:The patients admitted to the PICU from April 1, 2022, to March 31, 2023. The age ranged from 28 days to 18 years. All patients met the criteria of severe sepsis or septic shock.INTERVENTIONS:None.MEASUREMENTS AND MAIN RESULTS:Of the 31 PICUs invited to participate, 12 PICUs (capacity of 292 beds) enrolled patients in the study. During the study period, 11,238 children were admitted to the participating PICUs, 367 (3.3%) of whom met the diagnosis of severe sepsis or septic shock. The most prevalent sites of infection were the respiratory system (55%) and the digestive system (15%). The primary treatments administered to these patients included antibiotics (100%), albumin (61.3%), invasive mechanical ventilation (58.7%), glucocorticoids (55.6%), blood products (51%), gammaglobulin (51%), and vasoactive medications (46.6%). Sepsis-related mortality in the PICU was 11.2% (41/367). Nearly half of the sepsis deaths occurred within the first 3 days of PICU admission (22/41, 53.7%). The mortality rate of septic shock (32/167, 19.2%) was significantly higher than that of severe sepsis (9/200, 4.5%;p< 0.001). The outcomes of a multivariate logistic regression analysis suggested that a higher pediatric Sequential Organ Failure Assessment score, and the use of invasive mechanical ventilation and vasoactive medications were independently associated with PICU mortality in children with sepsis.CONCLUSIONS:This report updates the epidemiological data of pediatric sepsis in PICUs in Southwest China. Sepsis is still a life-threatening disease in children.
Expansion formulae for flexural-gravity wave propagation during wave blocking
Authors: Chandra Barman Sunil , Chanda Ayan 
Published: February 2024

Flexural-gravity wave blocking occurs in the presence of lateral compressive force. The existing expansion formulae for the velocity potential were limited in the case of distinct real roots of the dispersion relation with the multiplicity one. This limitation is overcome, and we obtain the complete solution for the flexural-gravity wave-maker problem at blocking and saddle points by deriving the expansion formula for velocity potential using the Fourier transform corresponding to the roots of the dispersion relation with multiplicity two and three, respectively. Further, we check the convergence of the newly derived expansion formulae by using the spectral representation of the associated eigenfunction. It has been proved that the eigenfunctions related to the expansion formulae are linearly dependent and satisfy the orthogonal mode-coupling relation. Next, we solve a model problem of flexural-gravity wave scattering by a crack using the derived expansion formulae and establish the energy balance relation by applying Green’s integral theorem at blocking points for infinite water depth. In addition, we have presented the validation of energy balance relation involving the generalized scattering coefficients.
Clinical application of whole-genome sequencing for precision oncology of solid tumors
Authors: Kim Ryul , Kim Seokhwi , Oh Brian Baek-Lok , Yu Woo Sik , Kim Chang Woo , Hur Hoon , Son Sang-Yong , Yang Min Jae , Cho Dae Sung , Ha Taeyang , Heo Subin , Jang Jeon Yeob , Yun Jae Sung , Kwack Kyu-Sung , Kim Jai Keun , Huh Jimi , Lim Sun Gyo , Han Sang-Uk , Lee Hyun Woo , Park Ji Eun , Kim Chul-Ho , Roh Jin , Koh Young Wha , Lee Dakeun , Kim Jang-Hee , Lee Gil Ho , Noh Choong-Kyun , Jung Yun Jung , Park Ji Won , Sheen Seungsoo , Ahn Mi Sun , Choi Yong Won , Kim Tae-Hwan , Kang Seok Yun , Choi Jin-Hyuk , Baek Soo Yeon , Lee Kee Myung , Kim Sun Il , Noh Sung Hyun , Kim Se-Hyuk , Hwang Hyemin , Joo Eunjung , Lee Shinjung , Shin Jong-Yeon , Yun Ji-Young , Park Junggil , Yi Kijong , Kwon Youngoh , Lee Won-Chul , Park Hansol , Lim Joonoh , Yi Boram , Koo Jaemo , Koh June-Young , Lee Sangmoon , Lee Yuna , Lee Bo-Rahm , Connolly-Strong Erin , Ju Young Seok , Kwon Minsuk 
Published: February 2024

AbstractGenomic alterations in tumors play a pivotal role in determining their clinical trajectory and responsiveness to treatment. While targeted panel sequencing (TPS) has been a key clinical tool over the past decade, advancements in sequencing costs and bioinformatics have now made whole-genome sequencing (WGS) a feasible single-assay approach for almost all cancer genomes in clinical settings. This paper reports on the findings of a prospective, single-center study exploring the real-world clinical utility of WGS (tumor and matched normal tissues) with two primary objectives: 1) assessing actionability for therapeutic options, and 2) providing clarity for clinical questions. Of the 120 various solid cancer patients enrolled, 95 (79%) successfully received genomics reports within a median of 11 working days from sampling to report. Analysis of these 95 WGS reports revealed that 72% (68/95) yielded clinically relevant insights, with 69% (55/79) pertaining to therapeutic actionability, and 81% (13/16) to clinical clarity. These benefits encompass selection of informed therapeutics and/or active clinical trials with driver mutations, tumor mutational burden (TMB) and mutational signatures, pathogenic germline variants that warrant genetic counseling, and information helpful for inferring cancer origin. Our findings highlight the potential of WGS as a comprehensive tool in precision oncology and advocate for its integration into routine clinical practice to provide a complete genomic landscape for tailored cancer management.