bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hostile attribution bias shapes neural synchrony in the left ventromedial prefrontal cortex during ambiguous social narratives
Authors: Lyu Yizhou , Su Zishan , Neumann Dawn , Meidenbauer Kimberly L. , Leong Yuan Chang 
Published: February 2024

Hostile attribution bias refers to the tendency to interpret social situations as intentionally hostile. While previous research has focused on its developmental origins and behavioral consequences, the underlying neural mechanisms remain underexplored. Here, we employed fNIRS to investigate the neural correlates of hostile attribution bias. While undergoing fNIRS, male and female participants listened to and provided attribution ratings for 21 hypothetical scenarios where a character's actions resulted in a negative outcome for the listener. Ratings of hostile intentions were averaged to obtain a measure of hostile attribution bias. Using intersubject-representational similarity analysis, we found that participants with similar levels of hostile attribution bias exhibited higher levels of neural synchrony during narrative listening, suggesting shared interpretations of the scenarios. This effect was localized to the left ventromedial prefrontal cortex (VMPFC), and was particularly prominent in scenarios where the character's intentions were highly ambiguous. We then grouped participants into high and low bias groups based on a median split of their hostile attribution bias scores. A similarity-based classifier trained on the neural data classified participants as having high or low bias with 75% accuracy, indicating that the neural time courses during narrative listening was systematically different between the two groups. Furthermore, hostile attribution bias correlated negatively with attributional complexity, a measure of one's tendency to consider multifaceted causes when explaining behavior. Our study sheds light on the neural mechanisms underlying hostile attribution bias and highlights the potential of using fNIRS to develop non-intrusive and cost-effective neural markers of this socio-cognitive bias.Significance StatementInferring the intentions from behavior is crucial for adaptive social functioning. A predisposition towards interpreting intentions as hostile is a significant predictor of interpersonal conflict and aggressive tendencies. Using fNIRS, we found that individual differences in hostile attribution bias shaped neural synchrony in the VMPFC while processing real-world social situations. Additionally, we were able to distinguish between participants with high and low hostile attribution bias from neural activity time courses. These results reveal how subjective interpretations of social situations are influenced by hostile attribution bias and reflected in the temporal dynamics of the VMPFC. Our findings lay the groundwork for future studies aimed at understanding the neurobiological basis of socio-cognitive biases, as well as interventions aimed at mitigating these biases.
Parental Mental Illness and the Likelihood of Child Out-of-Home Care: A Cohort Study
Authors: Nevriana Alicia , Kosidou Kyriaki , Hope Holly , Wicks Susanne , Dalman Christina , Pierce Matthias , Abel Kathryn M. 
Published: February 2024

OBJECTIVESTo detail the relationship between parental mental illness and the likelihood of out-of-home care (OHC) among their children, and to identify factors which modify this relationship.METHODSUsing Swedish national registers, children born in 2000 to 2011 (n = 1 249 463) were linked to their parents. Time-dependent parental mental illness (nonaffective and affective psychosis, substance misuse, depression, anxiety and stress, eating disorders, personality disorders, attention deficit hyperactivity disorder, autism, and intellectual disability), was identified through International Classification of Diseases codes.RESULTSAfter adjustment for socioeconomic factors, children living with mentally ill parents were 4 times as likely to be placed in OHC than children without (95% confidence interval [CI] 4.24–4.61). The highest hazard ratio (HR) was in the youngest children aged 0 to 1 year (5.77, 95% CI 5.42–6.14), exposed to maternal illness (HR 4.56, 95% CI 4.37–4.76), and parental intellectual disability (HR 4.73, 95% CI 4.09–5.46). Children with parental mental illness with multiple risk factors were at particularly high risk. Compared with children without parental mental illness, and those with university-educated parents, children whose parents had mental illness and only had education to age 16 had a 15 times higher risk of OHC (95% CI 13.75–16.54).CONCLUSIONSChildren with parental mental illness are considerably more likely to be removed from home into care during childhood, particularly during the first year of life and if they are from socially disadvantaged families. Greater knowledge of these risks should lead to increased support for vulnerable new families.
MDMA-assisted dialectical behavioral therapy for borderline personality disorder: A qualitative study of mental health clinicians
Authors: Inouye Ann M. , Wolfgang Aaron S. , Philhower Lianne T. 
Published: February 2024

AbstractIn 2021, the final series of phase 3 clinical trials looking at MDMA-AT for treatment-resistant post-traumatic stress disorder (PTSD) found that 71.2% of 3,4-methylenedioxymethamphetamine (MDMA) full-dose participants no longer met criteria for PTSD. MDMA-assisted therapy is not US Food and Drug Administration (FDA) approved in treating borderline personality disorder (BPD), and while PTSD is quite different from BPD, it is possible that some of the beneficial effects of MDMA-assisted therapy may be applicable in treating BPD. Interviewing two clinicians utilizing dialectical behavioral therapy treatment and two MDMA-assisted therapy clinicians was one way to examine the phenomenology of MDMA-assisted therapy with BPD individuals in a thoughtful manner. An exploratory, qualitative, interview-based study assessed clinicians' perspectives of MDMA-assisted therapy and BPD and increased our understanding of underlying therapeutic mechanisms and processes and the role of pharmacological factors in these treatment modalities, optimizing treatment context, and leading to improved clinical responses and patient recovery. The codes generated unique perspectives of the participants revealing a chronological narrative which included three phases of treatment.
Perceptions and attitudes towards psychedelic-assisted psychotherapy among health professionals, patients, and the public: A systematic review
Authors: Wells Alesha , Fernandes Merciana , Reynolds Lisa 
Published: February 2024

AbstractBackground and aimsScientific interest in the therapeutic potential of psychedelics has been experiencing significant growth. Understanding the perceptions of psychedelic assisted psychotherapy (PAP) among health professional, patients, and the public is essential to guide future research objectives, trial protocols, and identify any barriers to future implementation.MethodsA comprehensive search of the databases (Medline, EMBASE, PSYCHinfo, SCOPUS, and Web of Science) was conducted on the 29th of November, 2022. This review included cross-sectional, longitudinal, and quasi-experimental studies published in peer-reviewed journals exploring perceptions of PAP among the three stakeholder groups. Studies were limited to English-language and the years 2012–2022. The protocol and review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.ResultsThe sample consisted of 29 studies, including n = 17 health professional, n = 6 patients, and n = 6 public. Broadly, knowledge of PAP was low among all three stakeholder groups. There was mixed to positive belief in the therapeutic potential of psychedelics, with male gender, younger age, and personal psychedelic experience/knowledge being key predictors of more favourable views. The majority of findings reported strong endorsement of further research. Consistent themes were identified surrounding concerns about legal status, funding, access, side-effects, and implementation.ConclusionThe evaluated research indicates a need for further research that will provide clarity about safety and elucidate how PAP may be implemented in public health settings. Further education of health professionals and the public should be a priority.
THE HARMONIOUS BLEND OF CULTURAL ACCULTURATION AND ISLAMIC PRINCIPLES WITHIN THE RICH TAPESTRY OF JAMBI’S RELIGIOUS TRADITIONS
Authors: Zulgafrin Zulgafrin 
Published: February 2024

ABSTRACTThis research was carried out to determine Islamic contact with the Malay community in Jambi, through Arab traders and Sufis who entered the area across Jambi City. Apart from that, we also know the process of interaction between Islam and community culture which ultimately gave birth to acculturation to Malay culture and Islamic values. The method used in the research is the historical research method to reveal the history of the entry of Islam into the people of Seberang Jambi City. Research stages include heuristics, criticism, interpretation and historiography. The research results show that the interaction of Islam and Malay society gave birth to acculturation of Islamic culture and values. The acculturation process is through trade relations, marriage, and interactions in adjacent communities. It can be seen in the religious traditions across the city of Jambi, such as in the Malay traditional seloko which contains Islamic values. Apart from that, religious rituals also developed in Jambi Malay society, such as assyuro commemoration, grave pilgrimage, nuak ketan, baby thanksgiving and nisfu Sya'ban, and in artistic traditions including Gambus, zapin dance, Dana Syarah and Hadrah dance.Keywords: Acculturation, Islam and Malay Culture, Religious Culture. ABSTRAKPenelitian ini dilakukan untuk mengetahui kontak Islam dengan masyarakat Melayu di Jambi, melalui para pedagang Arab dan para Sufi yang masuk ke wilayah seberang Kota Jambi. Selain itu kita juga mengetahui proses interaksi antara Islam dan budaya masyarakat yang pada akhirnya melahirkan akulturasi budaya Melayu dan nilai-nilai Islam. Metode yang digunakan dalam penelitian adalah metode penelitian sejarah untuk mengungkap sejarah masuknya Islam ke masyarakat Seberang Kota Jambi. Tahapan penelitian meliputi heuristik, kritik, interpretasi dan historiografi. Hasil penelitian menunjukkan bahwa interaksi Islam dan masyarakat Melayu melahirkan akulturasi budaya dan nilai-nilai Islam. Proses akulturasi tersebut melalui hubungan dagang, perkawinan, dan interaksi dengan masyarakat yang berdekatan. Hal ini terlihat pada tradisi keagamaan yang ada di Kota Jambi, seperti pada seloko adat melayu yang mengandung nilai-nilai keislaman. Selain itu, ritual keagamaan juga berkembang pada masyarakat Melayu Jambi, seperti peringatan assyuro, ziarah kubur, nuak ketan, syukuran bayi dan nisfu Sya'ban, serta dalam tradisi kesenian antara lain Gambus, tari zapin, Dana Syarah, dan tari Hadrah.Kata Kunci: Akulturasi, Islam dan Budaya Malayu, Budaya Beragama
Peran Manajemen Pendidikan Islam Bagi Pesantren Di Tengah Pandemi Covid-19
Authors: Anshori Isa , Maziyah Elok 
Published: February 2024

Abstract: The purpose of this study is to get information about the impact COVID-19 has on the boarding school of Islamic education institutions and identify the role of Islamic education management in the boarding school of Islamic education in dealing with COVID-19. The study uses qualitative methods used to learn information about the effects of COVID-19 on boarding schools. Limited to one respondent is KH. Ilyas Siraj who is the head of the foundation of the boarding school Nurul Islam Karang Cempaka, Bluto, Sumenep, Madura. The interview was conducted by the questions provided by three, where the interview was conducted at his residence. The result of this study is that boarding schools have had very profound effects during the COVID-19 outbreak. Among other things, there are canceled boarding programs, uncontrolled and irreplaceable educational of student character, and finally an aspect of management activity is not well because of the government's policies on the corona strains of education for education.
Keywords: COVID-19 pandemic, Islamic boarding school, the role of Islamic education management.
Abstrak : Tujuan dari penelitian ini adalah untuk mendapatkan informasi mengenai dampak adanya COVID-19 bagi lembaga pendidikan Islam pesantren serta mengidentifikasi peranan manajemen pendidikan Islam pada lembaga pendidikan Islam pesantren dalam menghadapi pandemic COVID-19. Penelitian ini menggunakan metode kualitatif untuk memahami dampak COVID-19 bagi pesantren. Subjek penelitiannya ditentukan secara purposif yaitu KH. Ilyas Siraj yang merupakan pengasuh sekaigus ketua yayasan dari Pondok Pesantren Nurul Islam Karang Cempaka, Bluto, Sumenep, Madura. Teknik pengumpulan data menngunakan observasi terfokus, wawancara mendalam dan dokumentasi. Data yang dihimpun dianalisis melalui reduksi data, display data dan mengambil kesimpulan. Hasil penelitian menunjukkan, terdapat beberapa dampak yang teramat sangat dirasakan oleh pesantren ditengah adanya wabah covid-19, yaitu pesantren terpaksa memulangkan para santri, terdapat berbagai macam program kegiatan pesantren yang dibatalkan, penanaman pendidikan karakter santri yang tidak dapat terkontrol dan tidak dapat tergantikan dengan system online, dan yang terakhir aspek kegiatan manajemen tidak berjalan baik karena kebijakan pemerintah mengenai wabah corona bagi pendidikan dirasa terlalu mendadakan.
Kata kunci : pandemi COVID-19, Pesantren, Peran Manajemen Pendidikan
Effect of the bone marrow mesenchymal stromal cells cytokine-producing activity on mobilization of hematopoietic stem cells
Authors: Poponina E. A. , Pestrikova A. O. , Nazarova E. L. , Isaeva N. V. , Fokina E. S. , Endakova A. I. , Minaeva N. V. 
Published: February 2024

Hematopoietic stem cell transplantation is used to treat hemoblastoses and some other diseases. Depending on the diagnosis, autologous cells of the patient or allogeneic cells obtained from a healthy related or unrelated donor are used. A sufficient count of harvested hematopoietic progenitor cells is necessary for successful transplantation. Currently, stimulation of their egress from the bone marrow into the peripheral blood by a granulocyte colony-stimulating factor, followed by collection by leukapheresis, is widely used for their preparation. Hematopoietic stem cells leave the bone marrow niche formed by the stromal microenvironment when their holding bonds are interrupted. Mesenchymal stromal cells regulate the release of hematopoietic precursors by producing various cytokines and other biologically active substances. Therefore, the study of the functional properties of bone marrow mesenchymal cells can help in solving the problem of “poor” mobilizations that occur in patients with multiple myeloma.The aim of the study was to estimate the effectiveness of mobilization of hematopoietic stem cells depending on the cytokine-producing ability of mesenchymal stromal cells in the bone marrow of donors and patients with multiple myeloma.The yields of hematopoietic progenitors were studied in 10 donors (median age 27 years) and 18 patients with multiple myeloma (median age 57 years). In donors, the release of hematopoietic stem cells into the peripheral blood was stimulated by subcutaneous administration of G-CSF at a dose of 10 μg/kg/day. Patients with multiple myeloma received vinorelbine at a dose of 35 mg/m2 of body surface, followed by administration of G-CSF (10 μg/kg/day subcutaneously). A culture of mesenchymal stromal cells was obtained from bone marrow taken prior to mobilization and the content of interleukins IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α and IFN-γ in supernatants was studied by enzyme-linked immunosorbent assay using kits of reagents produced by Vector-Best (Novosibirsk).Patients with multiple myeloma were characterized by high secretion of the pro-inflammatory cytokine IL-2 (4.70 pg/ml vs 3.55 pg/ml in healthy individuals, p=0.003) and low IFN-γ (0.41 pg/ml vs 2.14 pg/ml in healthy, p<0.001), but no relationship was found between these cytokines and the hematopoietic stem cells yield. The present study showed that in patients with ineffective harvesting of hematopoietic precursors, secretion of IL-8 by stromal cells was low (308.08 pg/ml vs 561.29 pg/ml in healthy individuals, p=0.04).The obtained results are consistent with the literature data on the important role of IL-8 in the mobilization of hematopoietic stem cells, which allows to consider IL-8 as an informative marker for predicting the insufficient yields of hematopoietic precursors.
A new approach to immunosuppressive therapy in patients with glomerulonephritis with nephrotic syndrome
Authors: Kudryashov S. I. , Stenina M. A. , Karzakova L. M. , Lutkova T. S. 
Published: February 2024

Glomerulonephritis (GN) is a group of immuno-inflammatory kidney diseases with predominant glomerular lesions that are difficult to treat. The greatest problems are caused by the treatment of GN with nephrotic syndrome, which often has a recurrent course. The aim of the research was to study the effectiveness of recombinant interleukin-2 (rIL-2) therapy in the GN patients with nephrotic syndrome. 62 patients with a nephrotic form of primary GN with frequent relapses admitted to the Nephrology Department have been recruited into the study. The age of patients was from 18 to 65 years. The patients underwent standard examinations, as well as immunological studies, before administration of the anti-relapse treatment, and 12 months after the treatment was started. Immunological testing included immunophenotyping of lymphocytes with counting of T and B lymphocytes, immunoregulatory and activated subpopulations of T lymphocytes, determination of urinary immunoglobulins (IgM, IgG, IgA) by immunoturbidimetric assays, proinflammatory cytokines – IL-1β, IL-8, IL-17A and anti-inflammatory cytokine IL-10 by ELISA tests. As a result of studies, the examined patients showed an increased contents of T helper cells, activated T lymphocytes (CD8+HLA-DR+CD45+, CD3+CD8brightCD38+) along with decreased numbers of Treg cells and an increased contents of proinflammatory cytokines IL-1β, IL-8, IL-17A and immunoglobulins of all three classes in urinary samples.The cohort of patients with GN selected for the study was divided in two groups (the main group and the comparison group). In addition to nephroprotective and steroid therapy, the treatment regimen of patients included rIL-2 in the main group, or cyclophosphamide in the comparison group. Regardless of the method used, the levels of protein, IgG and IL-17A in the urine proved to be decreased relative to the initial values; the contents of B cells and HLA-DR+ cytotoxic T lymphocytes in peripheral blood were found to be decreased. The revealed changes were more pronounced in the main group of patients. By 12 months after starting the treatment, the mentioned indexes began to differ significantly in the main group from those in the comparison group. Serum creatinine levels, numbers of T helper cells and Treg cells, IL-1β levels in urine did not undergo significant changes in the comparison group, whereas a decrease in serum creatinine and urinary IL-1β was registered in the main group of patients, along with decreased number of T helpers and increased numbers of Treg cells. In the main group of patients treated with rIL-2, the average number of relapses per year decreased by 4 times, showing only a 1.2-fold decrease in the comparison group. Hence, the low-dose therapy with rIL-2 may be considered an effective and safe alternative to conventional immunosuppressive therapy and a new option of the targeted treatment of glomerulonephritis with frequent recurrence of nephrotic syndrome.
Cytokine profile in patients with chronic myeloid leukemia
Authors: Aleksandrova T. N. , Mulina I. I. , Lyamkina A. S. , Studenikina A. A. , Varaksin N. A. , Mikhaylova E. S. , Pospelova T. I. , Autenshlyus A. I. 
Published: February 2024

Resistance to tyrosine kinase inhibitors (TKIs) is currently an important clinical problem in the management of patients with chronic myeloid leukemia (CML). Recent studies suggested that aberrant cytokine secretion may be among the BCR/ABL-independent mechanisms of resistance, thus contributing to the persistence of leukemic stem cells in spite of continuous targeted therapy. The aim of the study was to evaluate concentration of cytokines in the serum of patients with CML depending on the efficiency of therapy.Quantitative determination of the cytokines (TNFα, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17, IL-18, IFNα and VEGF) in blood serum of patients with chronic-phase CML (n = 84) and healthy subjects (n = 30) was performed using enzyme immunoassay (ELISA). The patients with CML were divided into 3 groups depending on the duration of therapy: group I, newly diagnosed patients (n = 10); group II, patients receiving therapy for < 12 months (n = 10); group III included patients receiving therapy for more than 12 months (n = 64).The results of our study showed that cytokine concentration among CML patients significantly differed, depending on the duration of therapy. Significantly higher concentration of IL-17, IL-6, IL-1β, IL-10, IL-18, IL-2 and TNFα was found in group I compared with control group. Group II patients also demonstrated significantly higher concentrations of TNFα, IL-6, IL-10, IL-18 and IFNα by comparison with control group, as well as higher concentration of IFNα compared with in groups I and III. In group III, concentrations of IL-17, IL-1β, TNFα, IL-6, IL-10, IL-18 were significantly higher than in control group. When compared with group I, it was found that concentrations of IL-1β, IL-2 and IL-18 were significantly lower. A direct correlation was found between expression levels of chimeric BCR/ABL gene, (a marker of CML malignancy), and concentrations of IL-1β and IL-17. ROC-analysis demonstrated high-quality models which showed an association between achievement of major molecular response (MMR) and low serum concentrations of IL-1β, IL-6 and IL-17.Hence, the results of our study have shown that determination of IL-1β, IL-6 and IL-17 concentrations may be a prognostic marker for assessing the efficiency of therapy and probability of achieving MMR in CML.