bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of Cryopreserved Oocytes in Patients With Poor Ovarian Response After Planned Oocyte Cryopreservation
Authors: Fouks Yuval , Sakkas Denny , Bortoletto Pietro E. , Penzias Alan S. , Seidler Emily A. , Vaughan Denis A. 
Published: January 2024

ImportancePoor ovarian response (POR) to stimulation may impact patients’ desire or need to utilize cryopreserved oocytes for family building in the future. These findings, captured by Society for Assisted Reproductive Technology (SART) national data, underscore the need for tailored counseling and further research into the decision-making processes influencing oocyte utilization.ObjectiveTo examine the association of ovarian response to stimulation and the number of vitrified oocytes with the likelihood and timing of patients returning for oocyte utilization following planned oocyte cryopreservation (OC).Design, Setting, and ParticipantsThis cohort study used data in the SART Clinical Outcome Reporting System for patients in US fertility clinics and data was used for eligible patients who underwent planned OC from January 2014 through December 2020. Data were analyzed from November 2022 to June 2023.Main outcomes and measuresThe association between number of oocytes cryopreserved on return rate to utilize cryopreserved oocytes and the time from vitrification to warming.ResultsA total of 67 893 autologous oocyte freezing cycles were performed in the US between 2014 and 2020, among 47 363 patients (mean [SD] age, 34.5 [4.7] years). Of these, 6421 (13.5%) were classified as patients with POR, with fewer than 5 oocytes vitrified across all ovarian stimulation cycles. A total of 1203 patients (2.5%) returned for oocyte warming and utilization. The rate of return was significantly higher in the POR group, with 260 (4.0%) returning compared with 943 (2.3%) in the normal responder group (P &amp;lt; .001). This trend was most notable in the age 30 to 34 years (warm cycle, 46 of 275 [16.7%] vs no warm cycle, 982 of 11 743 [8.4%]; P &amp;lt; .001) and age 35 to 39 years groups (warm cycle, 124 of 587 [21.1%] vs no warm cycle, 3433 of 23 012 [14.9%]; P &amp;lt; .001). The time elapsed from vitrification to warming was comparable between patients with POR (mean [SD], 716.1 [156.1] days) and normal responders (803.8 [160.7] days). A multivariate analysis adjusted for age, clinic region in the US, body mass index, and history of endometriosis was conducted to identify factors associated with the utilization of oocytes. The analysis revealed that having fewer than 5 oocytes vitrified was associated with higher odds of utilizing oocytes (OR, 1.52; 95% CI, 1.32-1.76).Conclusions and RelevanceThis cohort study reveals a distinct pattern in the utilization of cryopreserved oocytes among patients undergoing planned OC in the US. Despite the increase in number of patients pursuing OC, there is a notably low rate of return to utilize previously vitrified oocytes; notably, patients with POR are more likely to return, although the time to return is similar to those with normal ovarian response.
Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)
Authors: Lasee Steven , Dourson Michael L. , Onyema Chijioke 
Published: January 2024

AbstractThis chapter is about a series of short‐chain per‐ and polyfluoroalkyl substances (PFAS). In the past, PFAS were described as fluorinated fatty acids or sulfonates. The overall structure of PFAS is a carbon chain with fluorine atoms substituting for hydrogen atoms. The resulting chemicals are chemically stable, water and oil resistant, and useful for many industrial applications, such as in the formation of polymers. The most notorious in this group are the fluorinated fatty acids (carboxylates) or sulfonates. In biological systems, these chemicals are generally well‐absorbed by the oral route and resistant to metabolism but also have the unusual property of having drastically different elimination kinetics between mammalian species.The available literature on this group of PFAS (C7 and below) is modest. This chapter will not attempt to review all this literature. Rather, human studies will be emphasized. Since human studies often suggest associations between PFAS exposure and health outcomes, these studies will be followed by definitive experimental animal studies that give insights into the human evidence. Afterward, a summary of attempts to estimate potential human risk by various international agencies will be described. What will become obvious, however, is that the overall uncertainty in the database of some of these chemicals has led to widely divergent risk assessment positions that need to be resolved. Risk management decisions on specific members of this class of chemistries are seen to be premature without such scientific resolution.
Selected Fluoropolymers (A Class of PFAS Polymers)
Authors: Dourson Michael L. , Lasee Steven , Onyema Chijioke 
Published: January 2024

AbstractThis chapter is about a series of fluorinated polymers (fluoropolymers) which belong to a broad class of chemical substances referred to as per‐ and polyfluoroalkyl substances (PFAS). PFAS are a unique class of anthropogenic chemicals consisting of carbon and fluorine atoms joined by very strong bonds, resulting in high‐performance properties. The overall structure of these fluoropolymers is the covalent linkage of one or more monomers, at least one of which is generally short carbon chains with fluorine atoms substituting for hydrogen atoms. The resulting fluoropolymer is a much larger molecule with very different uses, kinetics, and potential toxicity than the constituent monomers. For example, fluoropolymers are generally not well‐absorbed, if at all, in biological systems, thus avoiding to a great degree of any untoward toxicity. Unlike the monomers, the resulting fluoropolymers are usually chemically stable, biologically inert and nonbioaccumulative, water and oil resistant, and useful for many industrial applications. Because the chemical structure of these fluoropolymers makes them generally biologically unreactive and chemically inert, the available epidemiology and toxicology literature is minimal. This chapter will review the literature on fluoropolymers but will also briefly discuss the toxicity of the constituent monomers. Afterward, a summary of estimates of potential human risk by various agencies will be described.For information and practical guidance on the use of terminology in regard to PFASs, readers are referred to the OECD PFAS Terminology report [OECD,Reconciling Terminology of the Universe of Per‐ and Polyfluoroalkyl Substances: Recommendations and Practical Guidance, OECD Series on Risk Management, No. 61, OECD Publishing, Paris, 2021. Available athttps://www.oecd.org/chemicalsafety/portal‐perfluorinated‐chemicals/terminology‐per‐and‐polyfluoroalkyl‐substances.pdf. Accessed October 10, 2023).
Association of COVID‐19 Vaccinations With Flares of Systemic Rheumatic Disease: A Case‐Crossover Study
Authors: Braverman Genna , Barbhaiya Medha , Nong Minerva , Bykerk Vivian P. , Hupert Nathaniel , Lewis Colby , Mandl Lisa A. 
Published: January 2024

ObjectiveWe aimed to determine the association of COVID‐19 vaccination with flares of systemic rheumatic disease (SRD).MethodsAdults with systemic rheumatic disease (SRD) in a single‐center COVID‐19 Rheumatology Registry were invited to enroll in a study of flares. COVID‐19 vaccine information from March 5, 2021, to September 6, 2022, was obtained from chart review and self‐report. Participants self‐reported periods of SRD flare and periods without SRD flare. “Hazard periods” were defined as the time before a self‐report of flare and “control periods” as the time before a self‐report of no flare. The association between flare and COVID‐19 vaccination was evaluated during hazard and control periods through univariate conditional logistic regression stratified by participant, using lookback windows of 2, 7, and 14 days.ResultsA total of 434 participants (mean ± SD age 59 ± 13 years, 84.1% female, 81.8% White, 64.5% with inflammatory arthritis, and 27.0% with connective tissue diseases) contributed to both the hazard and control periods and were included in analysis. A total of 1,316 COVID‐19 vaccinations were identified (58.5% Pfizer‐BioNTech, 39.5% Moderna, and 1.4% Johnson & Johnson); 96.1% of participants received at least one dose and 93.1% at least two doses. There was no association between COVID‐19 vaccination and flares in the subsequent 2, 7, or 14 days (odds ratio [OR] 1.46, 95% confidence interval [CI] 0.86–2.46; OR 1.09, 95% CI 0.76–1.55; and OR 0.85, 95% CI 0.64–1.13, respectively). Analyses stratified on sex, age, SRD subtype, and vaccine manufacturer similarly showed no association between vaccination and flare.ConclusionCOVID‐19 vaccination was not associated with flares in this cohort of participants with SRD. These data are reassuring and can inform shared decision‐making on COVID‐19 immunization.image
“Graphene Bubble Bridging” Enabled Flexible Multifunctional Carbon Fiber Membrane Toward K+ Storage Devices
Authors: Song Yan , Wu Yujie , Wang Yutai , Jia Yaduo , Gou Huiyang , Zhang Chengwei , Wang Gongkai , Yin Fuxing 
Published: January 2024

AbstractWidespread integration of carbon‐based membranes into prevailing fields like energy storage and material engineering is thwarted by a lack of functionality, customization, and compatibility, making the development of such carbon‐based membranes urgency yet challenging. Herein, a “graphene bubble bridging” strategy is adopted to fabricate the multifunctional carbon fiber membrane, in which graphene bubbles with optimized assembling not only endow the carbon fiber with superior flexibility and integrity by embedded bridging function, but also enhance the fast electron transport capability and electrolyte wettability. Few‐layer MoSSe nanosheets with expanded interlayer spacing as a typical energy storage material contribute to plentiful ion intercalation/deintercalation that can be well buffered within the robust fibers. The interlaced carbon fibers enable a self‐supporting framework that ensures good conductivity and mechanical stability as well. Such functional, customized, and compatible membranes with synergies can boost the attributes of advanced K+ storage devices, such as flexible K‐ion capacitors and K‐based dual‐ion batteries. This work can afford new insights for designing flexible electrode in the energy storage field, as well as various types of conformations that can bring more opportunities on developing flexible functional membranes for other fields (e.g., catalysts, electromagnetic shielding).
Infrared Irradiation‐Lattice Vibration Coupling‐Initiated N→Π* Electronic Transition in Carbon Nitride Nanosheets for Increased Photocatalysis
Authors: Jiang Daochuan , Hu Shaonian , Qu Yi , Tian Xu , Du Haiwei , Zhu Chuhong , Li Zhongjun , Yin Lisha , Yuan Yupeng , Liu Gang 
Published: January 2024

AbstractEnabling n→π* electronic transition in graphitic carbon nitride (g‐CN) can significantly enhance its photocatalytic performance by extending visible light absorption. However, achieving this transition remains a grand challenge due to the selection rule that restricts it to planar tri‐s‐triazine units of g‐CN. Here, an effective strategy to induce the n→π* transition in g‐CN nanosheets by coupling infrared irradiation with lattice vibrations is presented. Theoretical simulations reveal two prominent vibration modes perpendicular to tri‐s‐triazine units at 219 and 737 cm−1 can promote the corrugation of tri‐s‐triazine units and facilitate the n→π* electronic transition when coupled with infrared irradiation. Additionally, these vibrational modes enable the efficient exfoliation of bulk g‐CN into 2D nanosheets by overcoming the interplanar binding energy. Through femtosecond transient absorption spectra (fs‐TAS), the n→π* transition prolongs the lifetime of photocatalytically active shallow electron trapping states and charge separation states in g‐CN is demonstrated. Accordingly, the activated n→π* electronic transition and prolonged lifetime of photocatalytically active charges lead to an H2 generation rate of 2485 µmol h−1 gcat−1, ≈40 times higher than that of the bulk counterpart. This work highlights the effectiveness of coupling lattice vibrations with infrared irradiation to drive the n→π* transition for enhanced visible‐light photocatalysis.
Metal‐Phenolic Nanocapsules with Photothermal Antibacterial and Ros Scavenging Ability for Diabetic Wound Healing
Authors: Qin Xudong , Tian Rui , Wang Bo , Yang Haixia , Chen Junyang , Wang Xin , Zhou Jianliang , Chen Qing , Tian Jian , Yang Ying‐Wei 
Published: January 2024

AbstractThe presence of bacteria in diabetic wounds not only leads to the formation of biofilms but also triggers oxidative stress and inflammatory responses, which hinder the wound‐healing process. Therefore, it is imperative to formulate a comprehensive strategy that can proficiently eliminate bacteria and enhance the wound microenvironment. Herein, this work develops multifunctional metal‐phenolic nanozymes (TA‐Fe/Cu nanocapsules), wherein the one‐pot coordination of tannic acid (TA)and Fe3+/Cu2+ using a self‐sacrificial template afforded hollow nanoparticles (NPs) with exceptional photothermal and reactive oxygen species scavenging capabilities. After photothermal disruption of the biofilms, TA‐Fe/Cu NPs autonomously capture bacteria through hydrogen bonding interactions with peptidoglycans (the bacterial cell wall component), ultimately bolstering the bactericidal efficacy. Furthermore, these NPs exhibit peroxidase‐like enzymatic activity, efficiently eliminating surplus hydrogen peroxide in the vicinity of the wound and mitigating inflammatory responses. As the wound transitions into the remodeling phase, the presence of Cu2+ stimulates vascular migration and regeneration, expediting the wound‐healing process. This study innovatively devises a minimalist approach to synthesize multifunctional metal‐phenolic nanozymes integrating potent photothermal antibacterial activity, bacterial capture, anti‐inflammatory, and angiogenesis properties, showcasing their great potential for diabetic wound treatment.
An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment
Authors: Song Shanliang , Zhao Yue , Kang Miaomiao , Zhang Fei , Wu Qian , Niu Niu , Yang Hao , Wen Haifei , Fu Shuang , Li Xue , Zhang Zhijun , Tang Ben Zhong , Wang Dong 
Published: January 2024

AbstractOne‐for‐all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due to its excellent performance in cancer treatment. Benefitting from the superiority in balancing the diverse competing energy dissipation pathways, aggregation‐induced emission luminogens (AIEgens) are proven to be ideal templates for constructing one‐for‐all multimodal phototheranostic agents. However, to this knowledge, the all‐round AIEgens that can be triggered by a second near‐infrared (NIR‐II, 1000–1700 nm) light have not been reported. Given the deep tissue penetration and high maximum permissible exposure of the NIR‐II excitation light, herein, this work reports for the first time an NIR‐II laser excitable AIE small molecule (named BETT‐2) with multimodal phototheranostic features by taking full use of the advantage of AIEgens in single molecule‐facilitated versatility as well as synchronously maximizing the molecular donor‐acceptor strength and conformational distortion. As formulated into nanoparticles (NPs), the high performance of BETT‐2 NPs in NIR‐II light‐driven fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photodynamic‐photothermal synergistic therapy of orthotopic mouse breast tumors is fully demonstrated by the systematic in vitro and in vivo evaluations. This work offers valuable insights for developing NIR‐II laser activatable one‐for‐all phototheranostic systems.
Morphological Relaxation of Strained Epitaxial Films for Stripe‐Geometry Devices
Authors: Hannikainen Kennet D. R. , Deprat Fabien , Gourhant Olivier , Berbezier Isabelle , Aqua Jean‐Noël 
Published: January 2024

AbstractOne of the major issues when reducing the channel length in strained transistors is the stress relaxation that significantly degrades the carriers mobility. A new morphological evolution is reported here, describing the relaxation of a strained epitaxial film deposited on a pattern characterized by stripe geometry, both paradigmatic of two‐dimensional (2D) like systems, and characteristic of many devices. The thermodynamic surface diffusion framework accounting for elasticity and capillarity is investigated. The former is solved in two dimensions thanks to the Airy formalism. The resulting dynamical Schrödinger‐like equation governing the film shape evolution is then solved thanks to a decomposition on eigenmodes. It reveals different developments depending upon the system's geometric parameters and the time scale. Mass transfer occurs toward the relaxed areas and creates a ridge at the nanolayers edges, controlled by the geometry and the scale of the structure. These results allow to refine the potential control of electronic properties via the geometry of a system.
Fibronectin Connecting Cell Sheet Based on Click Chemistry for Wound Repair
Authors: Xu Wei , He Meng , Lu Qinghua 
Published: January 2024

AbstractAs a living repair material, cell sheet exhibits significant potential in wound repair. Nonetheless, wound healing is a complicated and protracted process that necessitates specific repair functions at each stage, including hemostasis and antibacterial activity. In this work, on the basis of harvesting the cell sheet via a photothermal response strategy, a fibronectin attached cell sheet (FACS) is prepared to enhance its wound repair capability. For this purpose, the azide group (N3) is initially tagged onto the cell surface through metabolic glycoengineering of unnatural sugars, and then the conjugate (DBCO‐fibronectin) comprises of the dibenzocyclooctyne (DBCO) and fibronectin with multiple wound repair functions is linked to N3 using click chemistry. Biological evaluations following this demonstrates that the FACS preparation exhibits excellent biocompatibility, and the fibronectin modification enhances the capacity for cell proliferation and migration. Moreover, in vivo wound healing experiment confirms the reparative efficacy of FACS. It not only has a wound closure rate 1.46 times that of a conventional cell sheet but also reduces inflammatory cell infiltration, promotes hair follicle and blood vessel regeneration, and encourages collagen deposition. This strategy holds enormous clinical potential and paves the way for advanced functional modifications of cell sheets.
One‐Minute Preparation of Iron Foam‐Drug Implant for Ultralow‐Power Magnetic Hyperthermia‐Based Combination Therapy of Tumors in Vivo
Authors: Xie Guangchao , Li Bingjie , Zhang Xuejun , Yu Jiaojiao , Sun Shao‐Kai 
Published: January 2024

AbstractThe magnetic hyperthermia‐based combination therapy (MHCT) is a powerful tumor treatment approach due to its unlimited tissue penetration depth and synergistic therapeutic effect. However, strong magnetic hyperthermia and facile drug loading are incompatible with current MHCT platforms. Herein, an iron foam (IF)‐drug implant is established in an ultra‐facile and universal way for ultralow‐power MHCT of tumors in vivo for the first time. The IF‐drug implant is fabricated by simply immersing IF in a drug solution at an adjustable concentration for 1 min. Continuous metal structure of IF enables ultra‐high efficient magnetic hyperthermia based on eddy current thermal effect, and its porous feature provides great space for loading various hydrophilic and hydrophobic drugs via “capillary action”. In addition, the IF has the merits of low cost, customizable size and shape, and good biocompatibility and biodegradability, benefiting reproducible and large‐scale preparation of IF‐drug implants for biological application. As a proof of concept, IF‐doxorubicin (IF‐DOX) is used for combined tumor treatment in vivo and achieves excellent therapeutic efficacy at a magnetic field intensity an order of magnitude lower than the threshold for biosafety application. The proposed IF‐drug implant provides a handy and universal method for the fabrication of MHCT platforms for ultralow‐power combination therapy.
D‐dimer and sinusoidal obstructive syndrome‐novel poor prognostic features of thrombotic microangiopathy in children after hematopoietic cellular therapy in a single institution prospective cohort study
Authors: Schoettler Michelle L. , French Kaley , Harris Anora , Bryson Elyse , Deeb Laura , Hudson Zuri , Obordo Jeremy , Chandrakasan Shanmuganathan , Parikh Suhag , Watkins Benjamin , Stenger Elizabeth , Qayed Muna , Chonat Satheesh , Westbrook Adrianna , Switchenko Jeffrey , Williams Kirsten M. 
Published: January 2024

AbstractTransplant‐associated thrombotic microangiopathy (TA‐TMA) is a common, severe complication of allogeneic hematopoietic cellular therapy (HCT). Even when treated in many studies, morbidity and mortality rates are high. This prospective single‐institution cohort study serially enrolled all allogeneic HCT recipients from August 2019–August 2022. Patients were universally screened for TA‐TMA and intermediate and high‐risk patients were immediately treated with eculizumab. Sub‐distribution cox‐proportional hazards models were used to identify sub‐distribution hazard ratios (sHR) for multi‐organ dysfunction (MOD) and non‐relapse‐related mortality (NRM). Of 136 patients, 36 (26%) were diagnosed with TA‐TMA and 21/36 (58%) developed MOD, significantly more than those without TA‐TMA, (p < .0001). Of those with TA‐TMA, 18 (50%) had high‐risk TA‐TMA (HR‐TA‐TMA), 11 (31%) had intermediate‐risk TA‐TMA (IR‐TA‐TMA), and 8 (22%) had standard risk (SR‐TA‐TMA). Twenty‐six were treated with eculizumab (1/8 SR, 7/11 IR, and 18/18 HR). Elevated D‐dimer predicted the development of MOD (sHR 7.6, 95% confidence interval [CI] 1.8–32.3). Children with concurrent sinusoidal obstructive syndrome (SOS) and TA‐TMA had an excess risk of MOD of 34% and data supported a biologic interaction. The adjusted NRM risk was significantly higher in the TA‐TMA patients (sHR 10.54, 95% CI 3.8–29.2, p < .0001), despite prompt treatment with eculizumab. Significant RF for NRM in TA‐TMA patients included SOS (HR 2.89, 95% 1.07–7.80) and elevated D‐dimer (HR 3.82, 95% CI 1.14–12.84). An unrelated donor source and random urine protein to creatine ratio ≥2 mg/mg were significantly associated with no response to eculizumab (odds ratio 15, 95% CI 2.0–113.6 and OR 6.5, 95% CI 1.1–38.6 respectively). TA‐TMA was independently associated with NRM despite early diagnosis and treatment with eculizumab in this large pediatric transplant cohort. Prognostic implications of D‐dimer in TA‐TMA merit further investigation as this is a readily accessible biomarker. Concurrent SOS is an exclusion criterion of many ongoing clinical trials, but these data highlight these patients could benefit from novel therapeutic approaches. Multi‐institutional clinical trials are needed to understand the impact of TA‐TMA‐targeted therapies.
Cobalt‐Catalyzed Asymmetric Aza‐Nozaki–Hiyama–Kishi (NHK) Reaction of α‐Imino Esters with Alkenyl Halides
Authors: Xia Tingting , Wu Yinhui , Hu Jiangtao , Wu Xianqing , Qu Jingping , Chen Yifeng 
Published: January 2024

AbstractChromium‐catalyzed enantioselective Nozaki–Hiyama–Kishi (NHK) reaction represents one of the most powerful approaches for the formation of chiral carbon‐heteroatom bond. However, the construction of sterically encumbered tetrasubstituted stereocenter through NHK reaction still posts a significant challenge. Herein, we disclose a cobalt‐catalyzed aza‐NHK reaction of ketimine with alkenyl halide to provide a convenient synthetic approach for the manufacture of enantioenriched tetrasubstituted α‐vinylic amino acid. This protocol exhibits excellent functional group tolerance with excellent 99 % ee in most cases. Additionally, this asymmetric reductive method is also applicable to the aldimine to access the trisubstituted stereogenic centers.