bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-design of a novel rehabilitation intervention for patients after ankle fracture surgery: establishing healthcare professional consensus
Authors: Bretherton C. , Al-Saadawi A. , Sandhu P. H. , Baird P. J , Griffin P. X. 
Published: January 2025

Abstract
Post-surgical rehabilitation advice after ankle fracture surgery, particularly regarding weight-bearing, varies significantly, leading to patient frustration and inconsistent recovery outcomes. This study aimed to establish a consensus for ankle fracture rehabilitation advice and identify content and implementation options for future interventions through consultation with healthcare professionals (HCPs). This study was part of the weight-bearing in ankle fractures (WAX) trial, a multicentre, randomised controlled trial. Using the behaviour change wheel (BCW) framework, three online workshops with HCPs were conducted between April 25, 2022, to May 4, 2022, to generate consensus on rehabilitation interventions. Participants completed pre-workshop tasks, and data were collected using an adapted nominal group technique (NGT). Workshop data were collated to create a survey with indicative statements about rehabilitation preferences. An online survey was subsequently disseminated to surgeons and physiotherapists between May 5, 2022, and July 13, 2022. Respondents were asked to indicate how strongly they agreed with various statements by ranking statements on a 5-point Likert scale from "strongly disagree" to "strongly agree”; 75% was used as a threshold for consensus agreement. Eight HCPs participated in the workshops, and 79 HCPs responded to the survey, representing 38 different NHS hospital trusts. Consensus was achieved on several key aspects: Patients could rest their foot on the floor while seated during non-weight-bearing periods and gradually increase weight-bearing based on comfort. It was agreed that orthotic boots are for comfort, and patients can discontinue use as early as two weeks post-operatively if weight-bearing is permitted. Guidelines for wound management, including when to get wounds wet and how to handle numbness, were also established. This study established a consensus for ankle fracture rehabilitation, emphasising patient autonomy and clear, standardised advice. The findings support the development of a tailored, patient-centred rehabilitation interventions, potentially delivered through digital platforms, to enhance recovery outcomes.
Survival outcomes of surgery and adjuvant chemotherapy in early-stage small cell and large cell lung cancer: a novel focus on tumors less than 1 cm
Authors: Vazquez-Urrutia Jorge Raul , Zhu Junjia , Takamori Shinkichi , Greenberg Max , Bhatia Priyanka , Komiya Takefumi 
Published: January 2025

Abstract

Background
The role of adjuvant chemotherapy in early-stage small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) remains unclear, particularly for small tumors. This study assesses the survival benefits of adjuvant chemotherapy after surgical resection with a novel focus on tumors less than 1 cm.

Materials and methods
Data from the National Cancer Database (NCDB) was extracted for patients with SCLC (n = 11,962) and LCNEC (n = 6821) who underwent surgical resection between 2004 and 2020. Exclusion criteria were limited survival (< 30 days), positive lymph nodes, distant metastases, large tumors (> 5 cm), residual microscopic disease, and neoadjuvant therapy. The primary outcome was overall survival (OS) from diagnosis, which was evaluated using Kaplan–Meier methods and multivariate Cox regression analyses. A propensity score matching (PSM) analysis was performed to compare outcomes in patients with SCLC and tumors ≤ 1 cm who received adjuvant chemotherapy versus surgery alone.

Results
The study involved 4114 SCLC and 3954 LCNEC patients. Adjuvant chemotherapy was associated with a significant increase median OS in both SCLC (6.26 vs. 4.18 years; p < 0.001) and LCNEC (7.02 years vs. 4.89 years; p < 0.001), while also being an independent predictor of better OS in SCLC (HR: 0.74) and LCNEC (HR: 0.75) (p < 0.001). The benefit was more noticeable in tumors ≤ 1 cm, showing a significant OS increase after PSM (median OS 7.34 vs. 5.02 years; p = 0.0048).

Conclusion
Adjuvant chemotherapy after surgery is associated with improved overall survival in stage I SCLC and LCNEC, particularly in SCLC tumors of 1 cm or less.
Reduction of spruce phytotoxicity by superheated steam torrefaction and its use in stimulating the growth of ecological bio-products: Lemna minor L
Authors: Szufa Szymon , Unyay Hilal , Piersa Piotr , Kędzierska-Sar Aleksandra , Romanowska-Duda Zdzislawa , Likozar Blaz 
Published: January 2025

Abstract
The use of biochar in agriculture is associated with the concepts of "carbon sink" and "carbon negative," which will constitute additional income for farms in the near future and may provide them with a key role in the fight against global warming. The existing model in the Scandinavian countries is one of the first to combine biochar with carbon dioxide biosequestration. Fertilizers with excessive nutrient content, salinity issues, impurities, or irregular pH levels can induce phytotoxicity, damaging plant health and growth. Torrefied woody biomass can work as a bulking agent, carbon carrier, or as an amendment for composting materials containing high amounts of water and/or nitrogen contents. Superheated steam torrefaction as a valorization process increases the amount of pores in which minerals can be stored and the plant will grow faster and bigger by using these pores agglomerated minerals. The torrefaction process was conducted using the DynTHERM TG Rubotherm high-temperature and high-pressure thermogravimetric analysis apparatus under conditions of superheated steam flow. Various residence times (10, 20, and 40 min) and torrefaction temperatures (250, 275, and 300 °C) were explored to assess their efficacy in reducing the phytotoxicity of torrefied spruce. To confirm this assumption, a toxicity test with Lemna minor L. was carried out according to Radić et al. (2011) and extended to the determination of chlorophyll index and chlorophyll fluorescence to assess the physiological status of the plants after treatment with different doses of spruce wood biocarbon. Research indicates that biochar positively impacts soil quality and plants. Thanks to its unique properties, biochar provides nutrients, enhancing fertilization efficiency [1]. Biochar, after concentrating and adsorbing the nutrients from the wastewater, can be used as a soil amendment or fertilizer. Biochar blended with organic residues full of nutrients is more effective in improving soil properties and crop yields than the exclusive application of pure biochar or other fertilizers. Traditional chemical fertilizers have drawbacks, such as rapid nutrient leaching, severe environmental pollution, and high costs. Therefore, biochar is gaining increasing recognition worldwide.
Dietary dopamine supplementation has no effect on ovary activity in queen-less or queen-right honeybee (Apis mellifera) workers
Authors: Knapp R. A. , Lovegrove M. R. , Norman V. C. , Duncan E. J. 
Published: January 2025

Abstract
Eusociality in honeybees (Apis mellifera) is characterised by a reproductive division of labour, where the queen monopolises reproduction while worker reproduction is constrained. This constraint is mediated by queen mandibular pheromone (QMP), which inhibits worker ovary development through Notch signalling and possibly oocyte apoptosis. Dopamine has been implicated in regulating reproduction in worker honeybees, with prior studies suggesting that dietary dopamine enhances ovary activity in queen-less workers. This study aimed to test whether dopamine supplementation could overcome QMP-mediated reproductive constraint in worker honeybees. Using caged honeybee experiments, we administered dopamine and its precursor L-dopa at a range of concentrations, both in the presence and absence of QMP. Results showed that neither dopamine nor L-dopa supplementation affected ovary development, survival rates, or food intake, which contrasts with a previous study. These findings suggest that dopamine may not be a major factor in QMP-mediated reproductive inhibition. Instead, we suggest that the multifaceted nature of QMP’s components together with the complexity of neuroendocrine signalling makes it likely that multiple redundant mechanisms regulate worker reproduction. Future research should investigate the interplay between nutrition, dopamine and QMP components to fully understand the regulation of ovary activation in honeybee workers.
Relative effectiveness of methods that sample worker honey bees to estimate Varroa destructor populations in Apis mellifera colonies
Authors: Taylor Michelle A. , Goodwin R. Mark , McBrydie Heather M. , Cox Harlan M. , Dominiak Bernard C. 
Published: January 2025

Abstract
Honey bee (Apis mellifera) colonies usually survive less than 16 months if populations of parasitic mite (Varroa destructor) are not controlled. The timing of when to control Varroa populations is aided by using methods that estimate the number of Varroa in hives. The relative efficacy of eight methods used to calculate the number of Varroa in samples of 300 adult bees was established: icing sugar shake (78%), low-suds detergent wash (86%), ethanol wash (72%), 10-min exposure to Apistan® (42%), ether roll (42%), a 30-s exposure to grapefruit leaf smoke (5%), a 30-s exposure to fluvalinate smoke (0%), and a 30-s exposure to tobacco leaf smoke (0%). A range of approaches were investigated to improve the efficacy and reliability of some of the methods. The following approaches improved the efficacy of four methods so that more than 95% of the Varroa were recovered: two 15-s shakes with at least 10 g of icing sugar; three 15-s washes with low-suds detergent; three 30-s washes with ethanol; and a 35-min exposure to an Apistan® strip.
Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study
Authors: Zhang Xiaodi , van Greevenbroek Marleen M. J. , Scheijen Jean L. J. M. , Eussen Simone J. P. M. , Kelly Jaycey , Stehouwer Coen D. A. , Schalkwijk Casper G. , Wouters Kristiaan 
Published: January 2025

Abstract

Purpose
Elevated methylglyoxal (MGO) levels and altered immune cell responses are observed in diabetes. MGO is thought to modulate immune cell activation. The current study investigated whether fasting or post-glucose-load plasma MGO concentrations are associated with circulating immune cell counts and activation in a large cohort study.

Methods
696 participants of The Maastricht Study (age 60.3 ± 8.4 years, 51.9% women) underwent an oral glucose tolerance test (OGTT). Fasting and post-OGTT plasma MGO concentrations were measured using mass spectrometry. Numbers and activation of circulating immune cells at fasting state were quantified using flow cytometry. Activation scores were calculated by averaging individual marker z-scores for neutrophils (CD11b, CD11c, CD16) and classical, intermediate, and non-classical monocytes (CD11b, CD11c, CX3XR1, HLA-DR). Associations were analysed using multiple linear regression adjusted for potential confounders. Stratified analyses were performed for glucose metabolism status for associations between plasma MGO levels and immune cell counts.

Results
Higher fasting plasma MGO concentrations were significantly associated with higher numbers of intermediate (β = 0.09 [95%CI 0.02; 0.17]) and non-classical monocytes (0.08 [0.002; 0.15]), but with lower activation scores for the intermediate monocytes (-0.14 [-0.22; -0.06]). Stratified analyses showed that positive associations between fasting plasma MGO levels and numbers of intermediate and non-classical monocytes appear only in participants with type 2 diabetes. Post-OGTT plasma MGO concentrations were not consistently associated with immune cells counts or activation.

Conclusion
Higher fasting plasma MGO concentrations are associated with higher intermediate and non-classical monocyte counts but with lower activation of intermediate monocytes.
Membranes of Polymer of Intrinsic Microporosity PIM-1 for Gas Separation: Modification Strategies and Meta-Analysis
Authors: Qiu Boya , Gao Yong , Gorgojo Patricia , Fan Xiaolei 
Published: January 2025

Abstract
Polymers of intrinsic microporosity (PIMs) have received considerable attention for making high-performance membranes for carbon dioxide separation over the last two decades, owing to their highly permeable porous structures. However, challenges regarding its relatively low selectivity, physical aging, and plasticisation impede relevant industrial adoptions for gas separation. To address these issues, several strategies including chain modification, post-modification, blending with other polymers, and the addition of fillers, have been developed and explored. PIM-1 is the most investigated PIMs, and hence here we review the state-of-the-arts of the modification strategies of PIM-1 critically and discuss the progress achieved for addressing the aforementioned challenges via meta-analysis. Additionally, the development of PIM-1-based thin film composite membranes is commented as well, shedding light on their potential in industrial gas separation. We hope that the review can be a timely snapshot of the relevant state-of-the-arts of PIMs guiding future design and optimisation of PIMs-based membranes for enhanced performance towards a higher technology readiness level for practical applications.
Primordial black holes and their gravitational-wave signatures
Authors: Bagui Eleni , Clesse Sébastien , De Luca Valerio , Ezquiaga Jose María , Franciolini Gabriele , García-Bellido Juan , Joana Cristian , Kumar Jain Rajeev , Kuroyanagi Sachiko , Musco Ilia , Papanikolaou Theodoros , Raccanelli Alvise , Renaux-Petel Sébastien , Riotto Antonio , Ruiz Morales Ester , Scalisi Marco , Sergijenko Olga , Ünal Caner , Vennin Vincent , Wands David ,   For the LISA Cosmology Working Group
Published: January 2025

Abstract
In the recent years, primordial black holes (PBHs) have emerged as one of the most interesting and hotly debated topics in cosmology. Among other possibilities, PBHs could explain both some of the signals from binary black hole mergers observed in gravitational-wave detectors and an important component of the dark matter in the Universe. Significant progress has been achieved both on the theory side and from the point of view of observations, including new models and more accurate calculations of PBH formation, evolution, clustering, merger rates, as well as new astrophysical and cosmological probes. In this work, we review, analyze and combine the latest developments in order to perform end-to-end calculations of the various gravitational-wave signatures of PBHs. Different ways to distinguish PBHs from stellar black holes are emphasized. Finally, we discuss their detectability with LISA, the first planned gravitational-wave observatory in space.
Assessment of Radiation absorption parameters of lithium disilicate glass-ceramic used in dentistry: experimental and theoretical approaches
Authors: Şahin Meryem Cansu , Kayhan Mehmet , Kayhan Emine 
Published: January 2025

Abstract
The primary scope of this study is to determine the gamma radiation absorption characteristics of a commercial LD glass-ceramic biomaterial through GAMOS simulation and Phy-X/PSD software, and then compare these results with experimental data to provide information about a radiation absorption property of this material. Elemental analyses of the LD glass-ceramic biomaterial were conducted in this research using X-ray diffraction (XRD) techniques. In the experimental study, gamma rays with energies from 81 keV to 1408 keV, emitted by sources such as 133Ba, 152Eu, 22Na, 137Cs, 57Co, and 60Co, were detected utilizing a gamma spectrometer with a 2″×2″ NaI(Tl) detector and associated electronic systems. The experimental radiation absorption data were analyzed alongside the results generated by the GAMOS simulation and the Phy-X/PSD program for comparison. The linear attenuation coefficients were 0.418, 0.361, 0.266, 0.289, 0.250, 0.208, 0.184, 0.175, 0.142, 0.177, 0.123, 0.123, 0.135, and 0.122 cm-1 at gamma energies of 81, 121.8, 276.4, 302.9, 356, 383.9, 511, 661.7, 779, 964.1, 1173.2, 1274.5, 1332.5, and 1408 keV, respectively. The mass attenuation coefficient values began to decrease rapidly as the gamma photon was increased to 1 MeV. Half value layer ranged from 1.315 cm at 81 keV to 6.243 cm at 1408 keV. Similarly, tenth value layer ​​also increased when photon energy increased. The mean free path values ​​vary between 2.394 cm− 1 and 8.184 cm− 1. In conclusion, it has been observed that the radiation absorption parameters of lithium disilicate dental biomaterial vary depending on the energy level.
Patterns of food preparation in children and adult diets and their associations with demographic and socio-economic characteristics, health and nutritional status, physical activity, and diet quality
Authors: Rei Mariana Correia Castro , Correia Daniela Macedo , Torres Duarte Paulo Martins , Lopes Carla Maria Moura , Costa Ana Isabel Almeida , Rodrigues Sara Simões Pereira 
Published: January 2025

Abstract
This cross-sectional study aimed to identify patterns of food preparation and examine their demographic and socio-economic drivers, along with impacts on health and nutritional status, physical activity, and diet quality. Dietary data from a national-representative sample (n = 5005, 3–84 years) of the Portuguese National Food, Nutrition, and Physical Activity Survey (IAN-AF 2015/16) were classified by preparation locations (at or away from home) and analysed via hierarchical clustering. Logistic regression models were used to examine associations between demographic and socio-economic factors and food preparation patterns and between these patterns and health and nutritional status, physical activity, and diet quality. The most common food preparation pattern (followed by 45.4% of participants) represented the highest intake of foods prepared by away-from-home establishments. Adolescents (vs. children, OR = 0.29, 95%CI = 0.17, 0.49) and older adults (vs. adults, OR = 0.37, 95%CI = 0.26, 0.53) had lower odds of following this pattern, whereas adult men (vs. women, OR = 4.20, 95%CI = 3.17, 5.57) had higher odds. Higher education, higher household income, and having children/adolescents in the household also increased the odds of eating foods prepared away from home, whereas living in rural areas or in food-insecure households decreased the odds. Noticeably, adults consuming more foods prepared away from home had lower odds of being overweight or obese (OR = 0.74, 95%CI = 0.56, 0.97), but higher odds of sedentarism (OR = 1.45, 95%CI = 1.08, 1.96) and poor diet (OR = 3.01, 95%CI = 2.08, 4.34) compared to those consuming more foods prepared at home by themselves. Dietary patterns marked by high away-from-home food preparation prevail. While these correlated with higher socio-economic status, sedentarism, and poorer diet — relatively to patterns with greater reliance on homecooked food — they were not linked to higher odds of obesity.
PUBLIC CONFIDENCE IN THE BANK OF ENGLAND
Authors: Garriga Ana Carolina 
Published: January 2025

Abstract
This article analyses the correlates of public confidence in the Bank of England (BoE) both at the aggregate and individual levels to answer the following two questions: What are the correlates of trust in the BoE? Is the inflation surge associated with a structural shift in attitudes towards the BoE? Data from the BoE’s Inflation Attitudes survey (2001–2023) suggest that although inflation performance and public trust seem associated at the aggregate level, at the individual level this correlation is weaker. Further analyses suggest some changes in the correlates of public confidence since the inflation surge.
Not So Irrelevant: The Epistemic Significance of Social Identity
Authors: Brinkerhoff Anna 
Published: January 2025

AbstractOur social identity affects what we believe. But, how should we epistemically evaluate this doxastic impact? Achieving a robust picture of the epistemic significance of social identity requires us to explore the understudied intersection of irrelevant influences and standpoint epistemology, which leads us to cases of double higher-order evidence. Reflecting on social identity through the lens of irrelevant influences gives us higher-order evidence of error, while reflecting through the lens of standpoint advantage gives us higher-order evidence of accuracy. We must weigh the strength of each piece of higher-order evidence case by case to epistemically evaluate the doxastic impact of social identity.
Revisiting Response-Dependent Responsibility
Authors: Carty Alexander 
Published: January 2025

AbstractResponse-dependence about moral responsibility argues that someone is morally responsible if and only if, and because, they're an appropriate target of reactive attitudes. But if we can be partially morally responsible, and if reactive attitudes are too coarse-grained to register small differences in normatively significant features of agents, then response-dependence is false. Shawn Wang dubs this the “Granularity Challenge.” This article rejects the second premise of the Granularity Challenge. Human emotions are fine-grained enough to register small differences in normatively significant features of agents. One illustrative example of this, I argue, is how children gradually emerge as partially responsible agents.
Reanalysis of sequences of alleged Javan tiger highlights the difficulties in studying big cats and the need for high-throughput sequencing
Authors: Khan Anubhab , Yulianto Yulianto , Aninta Sabhrina Gita , Wirdateti Wirdateti 
Published: January 2025

Abstract
Big cats are of conservation concern throughout their range, and genetic tools are often employed to study them for various purposes. However, there are several difficulties in using genetic tools for big cat conservation that could be resolved by modern methods of DNA sequencing. Recent reports of the sighting of a putative Javan tiger Panthera tigris sondaica in West Java, Indonesia, highlight some of the difficulties of studying the genetics of big cats. We reanalysed the data of the original reports and found that the conclusions were drawn based on incorrect copies of the genes. Specifically, the nuclear copy of the mitochondrial gene was analysed with the mitochondrial sequence, leading to discordance in the results. However, re-sequencing of the remaining DNA confirms that the sighting could have been that of a tiger, but the subspecies cannot be confirmed. This work highlights the urgency of developing high-throughput sequencing infrastructure in the tropics and the need for reliable databases for the study of big cats.