bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular access site complications with the use of closure devices in patients treated with platelet glycoprotein IIb/IIIa inhibitors during rescue angioplasty
Authors: Boccalandro Fernando , Assali Abid , Fujise Kenichi , Smalling Richard W. , Sdringola Stefano 
Published: October 2004

AbstractThe objective of this study was to evaluate the effectiveness of two different closure devices in patients undergoing rescue percutaneous coronary intervention (PCI) using IIb/IIIa inhibitors and to compare it with patients undergoing elective PCI. One hundred sixty‐two patients undergoing rescue PCI treated with IIb/IIIa inhibitors underwent vascular access site closure (6 Fr Perclose, n = 92, or 6 Fr Angioseal, n = 70). Vascular complications were compared with a sex‐ and age‐matched group (n = 100) of patients undergoing manual compression after sheath removal and a similar group of patients undergoing elective PCI (n = 196). The incidence of access site complications was not significantly different between the three groups undergoing rescue PCI and was not higher than in patient receiving GP IIb/IIIa inhibitors without fibrinolysis (RR = 0.95; 95% CI = 0.88–1.01). In patients undergoing rescue PCI and receiving IIb/IIIa inhibitors, closure devices allow early sheath removal and are associated with similar outcomes compared with manual compression and elective PCI regardless of the type of closure device used. Catheter Cardiovasc Interv 2004;63:284–289. © 2004 Wiley‐Liss, Inc.
Pseudoperforation during kissing balloon angioplasty
Authors: Panetta Carmelo J. , Fasseas Panayotis , Raveendran Ganesh , Garratt Kirk N. 
Published: October 2004

AbstractWe describe a case of apparent perforation during kissing balloon angioplasty of a bifurcation lesion. There was no evidence of perforation on follow‐up angiography or via intravascular ultrasound. Possible etiologies include minimal perforation that immediately sealed postdeflation or forced contrast into the microvascular bed via a proximal side branch. Cathet Cardiovasc Interv 2004;63:290–293. © 2004 Wiley‐Liss, Inc.
Use of gadobutrol in coronary angiography
Authors: Voss Reinhard , Grebe Mathias , Heidt Martin , Erdogan Ali 
Published: October 2004

AbstractGadobutrol was used in coronary angiography in three patients. All three patients had a substantially increased risk of developing renal complications with iodinated contrast agents. Gadobutrol was well tolerated in all three patients without any complications. The quality of the coronary angiograms was good. Catheter Cardiovasc Interv 2004;63:319–322. © 2004 Wiley‐Liss, Inc.
Sirolimus‐eluting stents for the prevention of restenosis in a worst‐case scenario of diffuse and recurrent in‐stent restenosis
Authors: Werner Gerald S. , Emig Ulf , Krack Andreas , Schwarz Gero , Figulla Hans R. 
Published: October 2004

AbstractFor recurrent in‐stent restenosis (ISR), surgical revascularization or brachytherapy is still the principal therapeutic options. The present investigation explores the efficacy of a sirolimus‐eluting stent to prevent restenosis in these lesions with a high risk of recurrence. In 22 consecutive patients with a recurrent and diffuse ISR, a sirolimus‐eluting stent was implanted to cover the restenotic lesion. All patients were followed clinically for at least 1 year and underwent a repeat angiography after 7 months. A quantitative coronary angiographic analysis was done. The target vessel failure was 14% in the sirolimus‐eluting stent group, with an angiographic late loss of only 0.39 ± 0.54. No subacute stent thrombosis was observed, and the 1‐year event‐free survival was 86%. The three cases with restenosis were all focal and could be successfully treated by additional drug‐eluting stent implantation. This study showed the efficacy of a sirolimus‐eluting stent for the prevention of restenosis in a worst‐case scenario of recurrent and diffuse ISR. The observed restenosis rate is lower than that reported after brachytherapy and suggests that sirolimus‐eluting stents are a promising treatment option for ISR. Catheter Cardiovasc Interv 2004;63:259–264. © 2004 Wiley‐Liss, Inc.
Safety and utility of intravascular ultrasound‐guided carotid artery stenting
Authors: Clark David J. , Lessio Sara , O'Donoghue Margaret , Schainfeld Robert , Rosenfield Kenneth 
Published: October 2004

AbstractIntravascular ultrasound (IVUS) is useful in evaluating coronary stent deployment. The aim of this study was to assess the safety and utility of IVUS in carotid artery stenting (CAS). Ninety‐eight consecutive high‐risk patients (107 arteries) underwent CAS. IVUS was performed prior to predilatation in 87 of the 107 vessels and in all 107 following stent deployment when an optimal angiographic appearance was obtained. Quantitative carotid angiography (QCA) and IVUS analysis were performed offline. Procedural success was 97%. Combined stroke or death at 30 days was 5.6%. IVUS measurements of the minimum lumen diameter (MLD) of the distal internal carotid artery (ICA) reference segment were similar to QCA (4.60 ± 0.74 vs. 4.74 ± 0.71 mm; P = 0.21). The ICA stent MLD was significantly smaller by IVUS compared to QCA (3.65 ± 0.68 vs. 4.31 ± 0.76 mm; P < 0.001). IVUS detected stent malapposition in 11%. IVUS findings, after an optimal angiographic result, necessitated additional treatment in 9% of procedures. Calcium was detected in more arteries with IVUS than angiography (61% vs. 46%; P < 0.05). Arteries with superficial lesion calcification subtending three or four quadrants by IVUS had a 31% incidence of stroke compared with a 1% incidence in arteries without severe superficial calcium (P < 0.001). We found IVUS imaging in CAS to be safe even prior to plaque dilatation. IVUS provides a more accurate assessment of stent dimensions, expansion, and apposition than angiography. Severe calcification by IVUS was associated with a higher risk of stroke. Cathet Cardiovasc Interv 2004;63:355–362. © 2004 Wiley‐Liss, Inc.
A prospective pancreatographic study of the prevalence of pancreatic carcinoma in patients with diabetes mellitus
Authors: Ogawa Yoshiaki , Tanaka Masao , Inoue Ken , Yamaguchi Koji , Chijiiwa Kazuo , Mizumoto Kazuhiro , Tsutsu Nobutaka , Nakamura Yoshihiro 
Published: October 2004

AbstractBACKGROUNDThe correlation between diabetes mellitus and pancreatic carcinoma is well documented, but no criteria have been established for the efficient selection of a high‐risk group among patients with diabetes mellitus.METHODSEighty‐seven patients were selected prospectively from outpatients with diabetes and underwent endoscopic retrograde pancreatography (ERP) according to the authors' original criteria, including the onset of diabetes after age 55 years, deterioration of diabetes or loss of body weight despite strict medical control, elevation of serum amylase and/or CA19‐9 levels, and pancreatobiliary abnormalities on routine ultrasonography. The patients were divided into two groups according to the time from the onset of diabetes to ERP: Patients in Group A had recent‐onset diabetes (within 3 years), and Group B patients had diabetes for > 3 years.RESULTSA total of 86 patients (excluding 1 patient with unsuccessful ERP who had undergone previous Billroth‐2 gastrectomy) were enrolled. There were 33 males and 53 females, age 40–90 years, with a mean age of 65.1 years. ERP demonstrated pancreatic carcinoma, although it was advanced disease in all patients, at an extremely high rate of 7.0% (6 of 86 patients) with no serious complications. The prevalence of pancreatic carcinoma in Group A (13.9%; 5of 36 patients) was significantly greater compared with Group B (2.0%; 1 of 50 patients; P = 0.0442). ERP with an indwelling balloon catheter and subsequent pancreatic juice sampling was performed in 49 patients, yielding positive cytology in 1 patient with pancreatic tail carcinoma, whereas measurements of carcinoembryonic antigen and CA19‐9 levels in pancreatic juice were of no use in the diagnosis of pancreatic carcinoma.CONCLUSIONSSelective ERP in patients with diabetes who were at high risk did not lead to the early diagnosis of pancreatic carcinoma, although this study showed that the 3‐year period after the onset of diabetes was critical. A more aggressive diagnostic approach within this period in diabetic patients with the authors' criteria may contribute to the earlier diagnosis of pancreatic carcinoma. Cancer 2002;94:2344–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10493
Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis
Authors: Koul Anjila , Willén Roger , Bendahl Pär‐Ola , Nilbert Mef , Borg Åke 
Published: October 2004

AbstractBACKGROUNDEndometrial carcinomas seem to carry a different prognosis depending on the presence or absence of concomitant complex atypical hyperplasia (hyperplasia). The molecular genetic profile of these two pathogenetic types, based on the genes reportedly mutated in these cancers, remains to be defined. Although microsatellite inability is reported in approximately 25% of endometrial carcinomas, its relation with the 2 pathogenetic types is not investigated.METHODSTo elucidate their underlying genetic changes, we analyzed 53 sporadic endometrial tumors, including 19 with and 34 without hyperplasia, for microsatellite instability (MSI), DNA ploidy (by flow cytometry), and for mutations in different genes.RESULTSMicrosatellite instability was present in 21%, DNA nondiploidy in 15%, and mutations in the PTEN, KRAS, CTNNB1/β‐catenin, TP53, and CDKN2A genes were detected in 32, 11, 13, 17, and 0% of the tumors, respectively. Microsatellite instability and mutations in these genes were present in tumors both with and without complex atypical hyperplasia. All cases with complex atypical hyperplasia were early stage (I–II) endometrioid tumors and associated with long progression free disease (P = 0.0004). Furthermore, most tumors with hyperplasia had low World Health Organization or International Federation of Gynecology and Obstetrics grade, had less myometrial invasion, and showed expression of estrogen receptors. All MSI tumors were diploid and had a significantly higher rate of PTEN mutations, but similar rates of KRAS, β‐catenin, and TP53 mutations compared with microsatellite stable tumors. TP53 mutations more often were found in nondiploid tumors but never in tumors with PTEN, KRAS, or β‐catenin mutations, and all PTEN mutations occurred in diploid tumors.CONCLUSIONSThus, PTEN, KRAS, β‐catenin, and TP53 mutations occurred in tumors both with and without hyperplasia, but PTEN and TP53 mutations were more common in tumors without hyperplasia. However, none of these genes seems to clearly distinguish tumors with and without hyperplasia, suggesting that other factors may be involved. Conversely, alterations in the PTEN and TP53 genes seem to define distinct subgroups of endometrial carcinoma, the former associated with diploidy and MSI, the latter with macroscopic chromosomal instability. Cancer 2002;94:2369–79. © 2002 American Cancer Society.DOI 10.1002/cncr.10498
High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas
Authors: Kouvaraki Maria , Gorgoulis Vassilis G. , Rassidakis George Z. , Liodis Petros , Markopoulos Christos , Gogas John , Kittas Christos 
Published: October 2004

AbstractBACKGROUNDThe cyclin‐dependent kinase inhibitor p27 plays a central role in cell cycle progression and is deregulated in breast carcinomas. Although its levels are inversely associated with tumor proliferation, overexpression of p27 has been reported in a subset of rapidly proliferating breast carcinoma cell lines.METHODSp27 levels were determined by immunohistochemistry in a series of 52 sporadic invasive breast carcinomas consisting of 47 ductal, 2 lobular, and 3 mixed; most tumors were Grade 2 or 3 (46 of 52) and Tumor Node Metastasis (TNM) Stage II–IV (46 of 52). E‐cadherin expression and its gene alterations at 16q22.1 were also studied, because in vitro evidence suggests a biologic association between p27 and E‐cadherin‐mediated growth suppression.RESULTSThe mean p27 labeling index (LI; percentage of p27 positive tumor cells) was 33.3% ± 25.3% (range, 0.1–85%). High p27 levels (p27 LI, > 50%) were observed in 14 (26.9%) of 52 carcinomas and were significantly associated with metastatic disease in axillary lymph nodes (14 of 33 vs. 0 of 19; P = 0.0007 by Fisher exact test). In addition, p27 LI was higher in the group of lymph node positive vs. lymph node negative tumors (mean p27 LI, 40.9% vs. 20.1%; P = 0.008 by Mann‐Whitney test). Reduced or absent E‐cadherin expression was found in 27 of 45 (60%) informative cases. Allelic imbalance of the 16q22.1 locus was found in 14 (27.5%) of 51 cases by using the microsatellite markers D16S503, D16S752, and D16S512. p27 LI and E‐cadherin alterations were not statistically related.CONCLUSIONSIn summary, high p27 levels detected in a subset of advanced breast carcinomas correlate with lymph node metastasis, suggesting that other mechanisms may bypass the cell cycle inhibitory role of p27 and provide growth advantage in these tumors. Cancer 2002;94:2454–65. © 2002 American Cancer Society.DOI 10.1002/cncr.10505
Major difference in the expression of δ‐ and μ‐opioid receptors between turtle and rat brain
Authors: Xia Ying , Haddad Gabriel G. 
Published: October 2004

AbstractThe reptilian turtle brain has a remarkably higher endurance for anoxia than mammalian brains. Since the response to O2 deprivation is dependent in a major way on the expression and regulation of membrane proteins, differences in such proteins may play a role in the species‐related differences in hypoxic responses. Because opioid system is involved in the regulation of hypoxic responses, we asked whether there are differences between rat and turtle brains in terms of opioid receptor expression. In this work, we compared the expression and distribution of δ‐and μ‐opioid receptors in the turtle and rat brains. Our results show that (1) the dissociation constant (Kd) for δ‐receptor binding was approximately four times lower and Bmax was more than double in the turtle brain homogenates than in rat ones; (2) the δ‐receptor binding density was heterogeneously distributed in the turtle brain, with a higher density in the rostral regions than in the brainstem and spinal cord, and was generally much higher than in rat brains from the cortex to spinal cord; (3) the δ‐opioid receptors in the rat brains were mostly located in the cortex, caudate putamen, and amygdala with an extremely low density in most subcortical (e.g., hippocampus and thalamus) and almost all brainstem regions; and (4) in sharp contrast to δ‐opioid receptors, μ‐opioid receptor density was much lower in all turtle brain regions compared with the rat ones. Our results demonstrate that the turtle brain is actually an organ of δ‐opioid receptors, whereas the rat brain has predominantly μ‐opioid receptors. Because we have recently found that δ‐opioid receptors protect neurons against glutamate and hypoxic stress, we speculate that the unique pattern of δ‐receptor receptor expression and distribution plays a critical role in the tolerance of turtle brain to stressful situations characterized by glutamate excitotoxicity. J. Comp. Neurol. 436:202–210, 2001. © 2001 Wiley‐Liss, Inc.
Lack of the protein tyrosine phosphatase SHP‐1 results in decreased numbers of glia within the motheaten (me/me) mouse brain
Authors: Wishcamper Celine A. , Coffin J. Douglas , Lurie Diana I. 
Published: October 2004

AbstractMice that are homozygous for the autosomal recessive motheaten allele (me/me) lack the protein tyrosine phosphatase SHP‐1. Loss of SHP‐1 leads to many hematopoietic abnormalities, as well as defects such as infertility and low body weight. However, little is known regarding the role SHP‐1 plays in the development of the central nervous system (CNS). To define the role of SHP‐1 in CNS development and differentiation, we examined the brains of me/me mice at various times after birth for neuronal and glial abnormalities. Although the brains of me/me mice are slightly smaller than age‐matched wild‐type littermates, both me/me and wild‐type brains are similar in weight, possess an intact blood‐brain barrier, and have largely normal neuronal architecture. Significantly, the current study reveals that me/me brain shows decreases in the number of glial fibriallary acidic protein (GFAP)+ astrocytes and F480+ microglia compared with wild‐type mice. In addition, decreased immunostaining for the myelin‐synthesizing enzyme CNPase was observed in me/me mice, confirming the loss of myelin in these animals, as reported (Massa et al. [2000] Glia 29:376–385). It is particularly significant that there is a decreased number of immunolabeled glia of all subtypes and that this deficit in glial number is not restricted to a particular class of glia. This suggests that SHP‐1 is necessary for the normal differentiation and distribution of astrocytes, microglia, and oligendrocytes within the murine CNS. J. Comp. Neurol. 441:118–133, 2001. © 2001 Wiley‐Liss, Inc.
Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
Authors: Winkelstein Beth A. , Rutkowski Maria D. , Sweitzer Sarah M. , Pahl Janice L. , DeLeo Joyce A. 
Published: October 2004

AbstractThe specific mechanisms by which nervous system injury becomes a chronic pain state remain undetermined. Historically, it has been believed that injuries proximal or distal to the dorsal root ganglion (DRG) produce distinct pathologies that manifest in different severity of symptoms. This study investigated the role of injury site relative to the DRG in (1) eliciting behavioral responses, (2) inducing spinal neuroimmune activation, and (3) responding to pharmacologic interventions. Rats received either an L5 spinal nerve transection distal to the DRG or an L5 nerve root injury proximal to the DRG. Comparative studies assessed behavioral nociceptive responses, spinal cytokine mRNA and protein expression, and glial activation after injury. In separate studies, intrathecal pharmacologic interventions by using selective cytokine antagonists (interleukin‐1 [IL‐1] receptor antagonist and soluble tumor necrosis factor [TNF] receptor) and a global immunosuppressant (leflunomide) were performed to determine their relative effectiveness in these injury paradigms. Behavioral responses assessed by mechanical allodynia and thermal hyperalgesia were almost identical in the two models of persistent pain, suggesting that behavioral testing may not be a sensitive measure of injury. Spinal IL‐1β, IL‐6, IL‐10, and TNF mRNA and IL‐6 protein were significantly elevated in both injuries. The overall magnitude of expression and temporal patterns were similar in both models of injury. The degree of microglial and astrocytic activation in the L5 spinal cord was also similar for both injuries. In contrast, the pharmacologic treatments were more effective in alleviating mechanical allodynia for peripheral nerve injury than nerve root injury, suggesting that nerve root injury elicits a more robust, centrally mediated response than peripheral nerve injury. Overall, these data implicate alternate nociceptive mechanisms in these anatomically different injuries that are not distinguished by behavioral testing or the neuroimmune markers used in this study. J. Comp. Neurol. 439:127–139, 2001. © 2001 Wiley‐Liss, Inc.
Primary epithelial malignant mesothelioma of the pericardium with deciduoid features: Cytohistologic and immunohistochemical study
Authors: Reis‐Filho Jorge S. , Pope Leonora Z.B. , Milanezi Fernanda , Balderrama Cynthia M.S.R. , Serapião Maria José , Schmitt Fernando C. 
Published: October 2004

AbstractMalignant mesothelioma with deciduoid features (MMWDF) is a recently characterized morphologic variant of epithelioid malignant mesothelioma, which frequently is misdiagnosed as peritoneal deciduosis or florid mesothelial hyperplasia. We report on the cytological, histological, immunohistochemical, and autopsy findings of a case of MMWDF arising in the pericardium of a 71‐yr‐old female patient. Cytology showed large, polygonal to round cells with pale to bright, eosinophilic cytoplasm, occasionally showing xantomatous pattern, containing a pleomorphic and vesicular nucleus with a single prominent nucleolus. Autopsy examination showed a neoplasm encasing the heart and great vessels. No other primary neoplasm was found. The histological analysis disclosed the typical features of MMWDF. Immunohistochemistry showed diffuse immunoreactivity for cytokeratin MNF116, HBME‐1, and calretinin in the neoplastic cells, as well as focal positivity for epithelial membrane antigen positivity in a brush border‐like pattern. All other markers were negative. We would like to stress that pathologists must be aware of the cytological and histological features of this rare variant of epithelioid malignant mesothelioma in order to avoid a misdiagnosis of a benign process or a metastatic malignancy. Diagn. Cytopathol. 2002;26:117–122; DOI 10.1002/dc.10068 © 2002 Wiley‐Liss, Inc.
Multitarget tracking using geographically separated radars
Authors: Kameda Hiroshi , Tsujimichi Shingo , Kosuge Yoshio 
Published: October 2004

AbstractJoint search data technology by geographically separated radars has drawn attention. In this technique, the observation data of several radars placed in a geographically wide area are collected for tracking processing. A characteristic of this technique is the reduction of the cross range error that is a problem in single radar. Hence, improved tracking capability is expected. However, for realization it is necessary to take into account the deviations of the coordinate axes between the state variable vector of the target and the observation vector for the observation model of the tracking filter. In this paper, the difference in the coordinate axes is studied. JPDA (Joint Probabilistic Data Association), a multitarget tracking algorithm making use of the observation information of radars placed at several locations, is studied. In order to evaluate the effectiveness of the present technique, computer simulation is carried out. It is found that the tracking performance is improved over the conventional method of using only one radar. © 2002 Scripta Technica, Electron Comm Jpn Pt 1, 85(5): 34–47, 2002
Proposal and evaluation of a method of remote access to FA controllers via the internet
Authors: Kusunoki Kazuhiro , Imai Isao , Negi Tomonori , Matsuda Nori , Ushijima Kazuo 
Published: October 2004

AbstractIn this paper, we propose a method of implementation of a remote access system to controllers in a manufacturing line via the Internet. In order to reduce development cost, we adopt the method of not modifying user interface‐related programs in existing controller access software, but modifying communication processing programs in it. We designed three types of implementation methods according to the communication protocol translation between the controller access communication protocols and TCP/IP. From the qualitative analysis of these three methods, we determined that the TCP/IP data wrapping method is the best among the three implementations. This paper also describes our prototype implementation of a remote access system based on TCP/IP data wrapping method and evaluates the results of our proposed method. © 2002 Scripta Technica, Electron Comm Jpn Pt 1, 85(6): 23–32, 2002