bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reusable educational resources for developing complex thinking on open platforms
Authors: Sanabria-Z Jorge , Alfaro-Ponce Berenice , González-Pérez Laura Icela , Ramírez-Montoya María Soledad 
Published: December 2023

AbstractIn the context of rapid technological advancements and the increasing availability of Open Educational Resources (OER), there is a growing need to foster complex thinking skills in higher education. The study aims to characterize OER platforms that facilitate the development of such skills, grounded in UNESCO’s recommendations and the evolving definitions of complex thinking. Utilizing a Systematic Literature Review (SLR), the research focuses on three key questions: the type of open license allowing 5R activities, the technical options based on the ALMS Framework, and the sub-competencies of complex thinking that can be nurtured through OER. The study identifies and categorizes key platforms conducive to the development of complex thinking skills, namely innovative, critical, scientific, and systemic thinking. These platforms are analyzed based on their licensing types and technical capabilities. Findings indicate that most of the platforms studied support 5R activities under Creative Commons licenses, require advanced editing skills, and more than half address multiple subcompetencies of complex thinking. The study concludes that the adaptation, reuse, and redistribution of OER can significantly contribute to fostering complex thinking skills, aligning educational practices with 21st-century demands. Recommendations include the development of frameworks by higher education institutions to normalize OER platforms and meet students’ needs, as well as future research to assess user behavior and sustainability of these platforms.
Empagliflozin repurposing in Parkinson’s disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways
Authors: Mohammed Noha Nabil , Tadros Mariane G. , George Mina Y. 
Published: December 2023

AbstractParkinson's disease is a neuroprogressive disorder characterized by loss of dopaminergic neurons in substantia nigra pars compacta. Empagliflozin (EMPA), a SGLT-2 inhibitor, is an oral hypoglycemic agent with reported anti-inflammatory and antioxidant effects. The current study aimed to evaluate the neuroprotective effect of EMPA in rotenone-induced Parkinson's disease. Rats were randomly distributed among five groups as follows: control, rotenone (2 mg/kg), rotenone + EMPA (10 mg/kg), rotenone + EMPA (20 mg/kg), and EMPA (20 mg/kg) groups. They were treated for 30 consecutive days. Rotenone reduced locomotor activity and retention time on the rotarod performance test while elongated descent latency time. On the other side, EMPA corrected these behavioral changes. These results were confirmed by histological examination and number of intact neurons. Moreover, rotenone induced alpha-synuclein accumulation, reduced tyrosine hydroxylase expression, dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid concentrations. On the other side, EMPA reversed such effects induced by rotenone. Depending on previous results, EMPA (20 mg/kg) was selected for further mechanistic studies. Rotenone ameliorated superoxide dismutase and catalase activities and enhanced lipid peroxidation, interleukin-1β, and tumor necrosis factor-α levels. By contrast, EMPA opposed rotenone-induced effects on oxidative stress and inflammation. Besides, rotenone reduced the expression of pAMP-activated protein kinase (pAMPK), peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), and Sirtuin-1 (SIRT-1), as well as abrogated NAD+/NADH ratio. However, EMPA activated the AMPK/SIRT-1/PGC-1α pathway. Moreover, rotenone hindered the wnt/β-catenin pathway by reducing the wnt-3a level and β-catenin expression. On the other side, EMPA triggered activation of the wnt/β-catenin pathway. Collectively, EMPA may provide a promising solution for Parkinson's patients worldwide.
A Mummers Farce – Retractions of Medical Papers Conducted in Egyptian Institutions
Authors: Menshawey Rahma , Menshawey Esraa , Mahamud Bilal A. 
Published: December 2023

AbstractEgypt currently holds the record for the most retractions in the continent of Africa according to the Retraction Watch database, and the 2nd highest of countries in the Middle East. The purpose of this study was to analyse the retracted medical publications from Egyptian affiliations, in order to delineate specific problems and solutions. We examined databases including Pubmed, Google Scholar and others, for all retracted medical publications that were conducted in an Egyptian institution, up to the date of August 31st 2022. We observed for the reason(s) for retraction, number of citations of the retracted work, the length of time between publication and retraction, and where the work was published (journal, publisher and impact factor). 68 retractions were identified. Most retractions were from the speciality of Obstetrics and Gynecology (n = 22), followed by Anesthesia (n = 7). The top 3 reasons for retraction were unreliable results, FFP level misconduct, and duplicate publication. The number of retractions significantly increased over the years, especially in 2022. When taking into account the number of medical publications per institution, the institute with the highest rate of retractions was Mansoura University, while the lowest rate was Cairo University. The number of retracted medical Egyptian publications continues to increase over time, although they represent a small portion of the overall body of Egyptian medical research. Future studies on retracted articles should employ a methodology that considers the institutions where the studies were conducted. This could allow a better understanding of specific problems in certain countries or regions.
A Shared Control Approach Based on First-Order Dynamical Systems and Closed-Loop Variable Stiffness Control
Authors: Xue Haotian , Michel Youssef , Lee Dongheui 
Published: December 2023

AbstractIn this paper, we present a novel learning-based shared control framework. This framework deploys first-order Dynamical Systems (DS) as motion generators providing the desired reference motion, and a Variable Stiffness Dynamical Systems (VSDS) (Chen et al. 2021) for haptic guidance. We show how to shape several features of our controller in order to achieve authority allocation, local motion refinement, in addition to the inherent ability of the controller to automatically synchronize with the human state during joint task execution. We validate our approach in a teleoperated task scenario, where we also showcase the ability of our framework to deal with situations that require updating task knowledge due to possible changes in the task scenario, or changes in the environment. Finally, we conduct a user study to compare the performance of our VSDS controller for guidance generation to two state-of-the-art controllers in a target reaching task. The result shows that our VSDS controller has the highest successful rate of task execution among all conditions. Besides, our VSDS controller helps reduce the execution time and task load significantly, and was selected as the most favorable controller by participants.
Solving the imbalanced data issue: automatic urgency detection for instructor assistance in MOOC discussion forums
Authors: Alrajhi Laila , Alamri Ahmed , Pereira Filipe Dwan , Cristea Alexandra I. , Oliveira Elaine H. T. 
Published: December 2023

AbstractIn MOOCs, identifying urgent comments on discussion forums is an ongoing challenge. Whilst urgent comments require immediate reactions from instructors, to improve interaction with their learners, and potentially reducing drop-out rates—the task is difficult, as truly urgent comments are rare. From a data analytics perspective, this represents a highly unbalanced (sparse) dataset. Here, we aim to automate the urgent comments identification process, based on fine-grained learner modelling—to be used for automatic recommendations to instructors. To showcase and compare these models, we apply them to the first gold standard dataset for Urgent iNstructor InTErvention (UNITE), which we created by labelling FutureLearn MOOC data. We implement both benchmark shallow classifiers and deep learning. Importantly, we not only compare, for the first time for the unbalanced problem, several data balancing techniques, comprising text augmentation, text augmentation with undersampling, and undersampling, but also propose several new pipelines for combining different augmenters for text augmentation. Results show that models with undersampling can predict most urgent cases; and 3X augmentation + undersampling usually attains the best performance. We additionally validate the best models via a generic benchmark dataset (Stanford). As a case study, we showcase how the naïve Bayes with count vector can adaptively support instructors in answering learner questions/comments, potentially saving time or increasing efficiency in supporting learners. Finally, we show that the errors from the classifier mirrors the disagreements between annotators. Thus, our proposed algorithms perform at least as well as a ‘super-diligent’ human instructor (with the time to consider all comments).
The abundance and localization of heat shock proteins (HSP)-60, -70, and -90 in the oviductal ampulla of hamadryas baboon (Papio hamadryas) during the menstrual cycle
Authors: Albrizio Maria , Desantis Salvatore , Lacitignola Luca , Laricchiuta Pietro , Guaricci Antonio Ciro , Cinone Mario 
Published: December 2023

AbstractThe presence of HSPs in female reproductive and their relationship with the steroid hormone fluctuation have been reported in several mammals but not in non-human primates. The present research dealt with the oviductal expression and localization of the more studied HSPs (60, 70, and 90) as well as the morphological changes in the Hamadryas baboon (Papio hamadryas) during the follicular, preovulatory, and luteal phases of the menstrual cycle. Therefore, western blots, histomorphological, and immunohistochemical analyses were carried out. The results of western blot analysis displayed the lowest HSP expression in the luteal phase. The histomorphology showed that the mucosal epithelium consisted of undifferentiated cuboidal cells in follicular and luteal phases and well-distinguishable columnar ciliated and non-ciliated cells during the preovulatory phase. Immunohistochemistry evidenced that the mucosal epithelium contained cytoplasmic and nuclear HSP60, 70, and 90 immunostaining in the follicular and luteal phases. During the preovulatory phase, the non-ciliated cells showed: (i) cytoplasmic HSP60; (ii) nuclear and cytoplasmic HSP90. Ciliated cells showed cytoplasmic and ciliary HSP70 and ciliary HSP90. The stromal cells and myocytes of muscular layer displayed a decreased cytoplasmic HSP60 in the preovulatory phase and nuclear and low cytoplasmic HSP70 throughout the menstrual cycle. Nuclear HSP90 decreased in ampulla stromal cells and the follicular phase myocytes. These findings indicate that the expression pattern of HSP60,70, and 90 is related to the morphofunctional features of the baboon oviductal ampulla during the menstrual cycle and could represent a referent point for further studies in the oviduct of Primates.
Electron Spin Resonance Probe Incorporation into Bioinks Permits Longitudinal Oxygen Imaging of Bioprinted Constructs
Authors: Sarvari Sajad , McGee Duncan , O’Connell Ryan , Tseytlin Oxana , Bobko Andrey A. , Tseytlin Mark 
Published: December 2023

Abstract
Purpose
Bioprinting is an additive manufacturing technology analogous to 3D printing. Instead of plastic or resin, cell-laden hydrogels are used to produce a construct of the intended biological structure. Over time, cells transform this construct into a functioning tissue or organ. The process of printing followed by tissue maturation is referred to as 4D bioprinting. The fourth dimension is temporal. Failure to provide living cells with sufficient amounts of oxygen at any point along the developmental timeline may jeopardize the bioprinting goals. Even transient hypoxia may alter cells' differentiation and proliferation or trigger apoptosis. Electron paramagnetic resonance (EPR) imaging modality is proposed to permit 4D monitoring of oxygen within bioprinted structures.

Procedures
Lithium octa-n-butoxy-phthalocyanine (LiNc-BuO) probes have been introduced into gelatin methacrylate (GelMA) bioink. GelMA is a cross-linkable hydrogel, and LiNc-BuO is an oxygen-sensitive compound that permits longitudinal oximetric measurements. The effects of the oxygen probe on printability have been evaluated. A digital light processing (DLP) bioprinter was built in the laboratory. Bioprinting protocols have been developed that consider the optical properties of the GelMA/LiNc-BuO composites. Acellular and cell-laden constructs have been printed and imaged. The post-printing effect of residual photoinitiator on oxygen depletion has been investigated.

Results
Models have been successfully printed using a lab-built bioprinter. Rapid scan EPR images reflective of the expected oxygen concentration levels have been acquired. An unreported problem of oxygen depletion in bioprinted constructs by the residual photoinitiator has been documented. EPR imaging is proposed as a control method for its removal. The oxygen consumption rates by HEK293T cells within a bioprinted cylinder have been imaged and quantified.

Conclusions
The feasibility of the cointegration of 4D EPR imaging and 4D bioprinting has been demonstrated. The proof-of-concept experiments, which were conducted using oxygen probes loaded into GelMA, lay the foundation for a broad range of applications, such as bioprinting with many types of bioinks loaded with diverse varieties of molecular spin probes.
Analytical exploration of the Mycenaean glass world via micro-PIXE: a contribution to our knowledge of LBA glass technology
Authors: Kaparou M. , Tsampa K. , Zacharias N. , Karydas A. G. 
Published: December 2023

AbstractDuring the Late Bronze Age, the Peloponnese with its palatial centers becomes the heartland of the Mycenaean world, resulting in an idiosyncratic material culture within the archaeological record, with glass constituting undoubtedly an important agent gaining prominence from the 15th cent. BC onwards, at the time when the palaces start rising and turning out to be characteristic to the Mycenaean material culture of the palatial elite. In this paper, the chemical composition of eleven (11) glass beads and relief plaques from three tombs of the necropolis in the area of Palaia Epidavros, Argolid in Greece have been studied to discuss aspects related to the nature of technology and provenance of fifteenth to eleventh century BC dated Mycenaean glass jewelry. The study resulted in the chemical fingerprinting of the collection by means of micro-PIXE succeeding in highlighting interesting technological aspects and assigning a likely origin of the studied samples. Importantly, since part of the assemblage had been studied in the past with the application of SEM–EDS and pXRF, the use of mPIXE enabled an enhanced discussion on glass related topics by comparing the results obtained.
Promotion of Psychological Well-Being and Life Satisfaction in Pre-Adolescents Through Mindfulness Amidst COVID-19
Authors: Magalhães Sofia , Carvalhais Lénia , Oliveira Patrícia , Francisco Cátia , Mourisco Cristina , Leal Teresa , Limpo Teresa 
Published: December 2023

Abstract
Objectives
Mindfulness-based programs (MBPs) seem to be a popular way to develop pre-adolescents’ regulation abilities, psychological health, and life satisfaction, especially in difficult times. However, research into the effects of MBPs and factors influencing their effectiveness is still scarce and mixed. In the interest of understanding how MBPs can effectively be used to enhance pre-adolescents’ regulation abilities, psychological health, and life satisfaction, this study aimed (a) to analyze and compare the effects of two 16-week-MBPs with different implementation dosages and (b) to evaluate the moderating role of participants characteristics on MBP effects.

Method
During the COVID pandemic, we conducted this quasi-experimental study, in which we compared three groups of Portuguese sixth graders (n = 105): daily MBP group (one long plus four short lessons per week), weekly MBP group (one long lesson per week), and a control group receiving socioemotional instruction. In particular, we examined MBP effects on attentional control, emotion regulation, psychological distress, and life satisfaction. Also, we evaluated the moderating role of participants’ gender, age, socioeconomic status, and baseline status on these effects.

Results
In comparison to the other groups, the daily MBP showed lower expressive suppression and stress symptoms as well as higher life satisfaction. Moreover, both MBP groups reported greater cognitive reappraisal than the control group. While the effects of MBPs on emotion regulation were found to be moderated by gender, age, and baseline expressive suppression, no additional moderating effects were observed.

Conclusions
These findings support the perspective that MBPs can serve as a broad preventive strategy, effectively promoting pre-adolescents’ psychological health and life satisfaction during challenging times.

Preregistration
This study is not preregistered.
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination
Authors: Mukherjee Sumon , Chakraborty Sourio , Basak Udit , Pati Subhadip , Dutta Apratim , Dutta Saikat , Roy Dia , Banerjee Shruti , Ray Arpan , Sa Gaurisankar , Das Tanya 
Published: December 2023

AbstractCancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles in evasion of immune surveillance. Tumor-promoting CD4+CD25+FOXP3+ T-regulatory cells (Tregs) have been described to abolish host defense mechanisms by impeding the activities of other immune cells including effector T cells. However, whether CSCs can convert effector T cells to immune-suppressive Treg subset, and if yes, the mechanism underlying CSC-induced Treg generation, are limitedly studied. In this regard, we observed a positive correlation between breast CSC and Treg signature markers in both in-silico and immunohistochemical analyses. Mirroring the conditions during tumor initiation, low number of CSCs could successfully generate CD4+CD25+FOXP3+ Treg cells from infiltrating CD4+ T lymphocytes in a contact-independent manner. Suppressing the proliferation potential as well as IFNγ production capacity of effector T cells, these Treg cells might be inhibiting antitumor immunity, thereby hindering immune-elimination of CSCs during tumor initiation. Furthermore, unlike non-stem cancer cells (NSCCs), CSCs escaped doxorubicin-induced apoptosis, thus constituting major surviving population after three rounds of chemotherapy. These drug-survived CSCs were also able to generate CD4+CD25+FOXP3+ Treg cells. Our search for the underlying mechanism further unveiled the role of CSC-shed immune-suppressive cytokine TGFβ, which was further increased by chemotherapy, in generating tumor Treg cells. In conclusion, during initiation as well as after chemotherapy, when NSCCs are not present in the tumor microenvironment, CSCs, albeit present in low numbers, generate immunosuppressive CD4+CD25+FOXP3+ Treg cells in a contact-independent manner by shedding high levels of immune-suppressive Treg-polarizing cytokine TGFβ, thus escaping immune-elimination and initiating the tumor or causing tumor relapse.
Effect of partial and global shielding on surface-driven phenomena in keyhole mode laser beam welding
Authors: Schmidt Leander , Schricker Klaus , Diegel Christian , Sachs Florian , Bergmann Jean Pierre , Knauer Andrea , Romanus Henry , Requardt Herwig , Chen Yunhui , Rack Alexander 
Published: December 2023

AbstractPartial shielding by means of local gas supply has proven to be very effective in reducing spatter. Besides the effect of gas-induced dynamic pressure, the shielding of oxygen is also highly relevant for melt pool dynamics and spatter formation due to the growth of oxides and the influence on surface tension. Therefore, this paper addresses the effect of local supplied argon on oxide growth and seam topography during keyhole mode laser beam welding of high-alloy steel AISI 304. To determine the shielding quality, the results are compared to laser beam welding in a global argon atmosphere. The topography of the upper weld seams was analyzed by scanning electron microscopy (SEM). An X-ray microanalysis (EDX) in line scan modus was performed to determine and to locate the elements which are covering the specimen surface. The chemical state of the found elements was quantified by X-ray photoelectron spectroscopy (XPS). In a last step, high-speed synchrotron X-ray imaging was performed to separate the effect of the gas-induced pressure and the gas-induced shielding on keyhole geometry. The results show that a local supply of argon contributes to a significant difference in oxide growth, affecting melt pool convection and weld seam geometry. It was further shown that the effect of gas flows at low flow rates is primarily because of oxygen shielding, as no significant difference in keyhole geometry was found by high-speed synchrotron X-ray imaging.
Exploring More Functions in Binders for Lithium Batteries
Authors: Zhang Lan , Wu Xiangkun , Qian Weiwei , Pan Kecheng , Zhang Xiaoyan , Li Liyuan , Jia Mengmin , Zhang Suojiang 
Published: December 2023

AbstractAs an indispensable part of the lithium-ion battery (LIB), a binder takes a small share of less than 3% (by weight) in the cell; however, it plays multiple roles. The binder is decisive in the slurry rheology, thus influencing the coating process and the resultant porous structures of electrodes. Usually, binders are considered to be inert in conventional LIBs. In the pursuit of higher energy density, many new binders are being developed for specific targets, such as the high-voltage (typically, $$\geqslant$$
⩾
4.5 V) cathodes, conversion/alloy-type cathodes/anodes with large volume effect, and solid-state batteries (SSBs), in which these binders demonstrate their various functions. They may influence the solid electrolyte interface component, ensure the electrode/electrolyte interfacial stability, transport ions/electrons in the electrodes, provide adhesion and flexibility to solid-state electrolyte (SSE) films, etc. Here in this review, we try to summarize the advances on binders, among which the ones for high-voltage cathode materials, thick electrodes, micro-sized silicon particles, SSEs and SSBs are highlighted. We believe that the advanced functional binders would play decisive roles in the future development of high-energy–density LIBs and SSBs.
Graphical Abstract
Binder usually takes a small part in batteries, while recent studies prove that it has multi-functions more than just adhesive.