bluuebunny/crossref_metadata_2025_split huggingface dataset:
High temporal resolution of hydrogen peroxide (H2O2) dynamics during heat stress does not support a causative role in coral bleaching
Authors: Schlotheuber Marlen , Voolstra Christian R. , de Beer Dirk , Camp Emma F. , Klatt Judith M. , Ghilardi Mattia , Neumüller Katharina , Ousley Sara , Bejarano Sonia 
Published: January 2024

AbstractHuman-induced climate change is causing ocean warming that triggers the breakdown of the coral–algal symbiosis. The proximate cause of this phenomenon, known as coral bleaching, is commonly attributed to the overproduction of reactive oxygen species (ROS) by the thermally stressed photosynthetic algal symbionts. However, direct evidence that algal ROS production (e.g., in the form of H2O2) and coral physiological stress are the ultimate cause of bleaching remains ambiguous. Here, we investigated the temporal dynamics of H2O2 and oxygen (O2) concentrations during thermally induced coral bleaching to disentangle cause from consequence. Microsensors at the tissue interface of Pocillopora damicornis measured H2O2 and O2 concentrations while exposing single nubbins to baseline temperatures (30 °C) and to minor (33 °C), moderate (36 °C), and high (39 °C) levels of acute heat stress using the Coral Bleaching Automated Stress System (CBASS). We show that a temporary decline in O2 concentration, accompanied by a declining photosynthetic efficiency and loss of Symbiodiniaceae and pigmentation, is the initial response to moderate thermal stress. This response was neither provoked nor followed by an increased H2O2 concentration at the coral tissue interface. A steady light-independent increase of H2O2 was only detected during high heat stress, resulting in the complete and permanent loss of photosynthetic activity. Our findings do not support a direct connection between algal photodamage and an increase in H2O2 concentration during thermally induced bleaching and suggest that more research on the function of H2O2 is warranted. This notion is further substantiated by the observation of an additional source of H2O2, likely oxidative bursts, that were common at the baseline temperature and under minor heat stress, while their occurrence decreased at moderate and high heat stress. Resolving the multifaceted and dynamic roles of H2O2 in coral bleaching is critical to better understand the response of the coral holobiont to thermal stress and identifying the processes underlying the breakdown of the coral–algal symbiosis.
Numerical investigation of terahertz wave driven electron acceleration generated from gas jet
Authors: Turnár Sz. , Sarkadi B. , Jolly S. W. , Hebling J. , Tibai Z. 
Published: January 2024

AbstractWe have investigated the dependence of the acceleration efficiency for three different proposed direct terahertz wave driven electron accelerator setups, including ionization in a gas jet source. We have numerically simulated and optimized the ionization processes using Particle-In-Cell code (EPOCH) and pointed out its crucial effect on the accelerating mechanism. Supposing two single-cycle terahertz driving pulses with 1 mJ energy per pulse we characterized the different accelerator arrangements. The main properties of the predicted electron beams with the average kinetic energy of 27 keV can be adapted to the requirements of different applications in the fC-pC charge range.
Contact force sensing manual catheter versus remote magnetic navigation ablation of atrial fibrillation: a single-center comparison
Authors: Schlögl Simon , Schlögl Klaudia Stella , Bengel Philipp , Haarmann Helge , Bergau Leonard , Rasenack Eva , Hasenfuss Gerd , Zabel Markus 
Published: January 2024

Abstract
Background
Data comparing remote magnetic catheter navigation (RMN) with manual catheter navigation in combination with contact force sensing (MCN-CF) ablation of atrial fibrillation (AF) is lacking. The primary aim of the present retrospective comparative study was to compare the outcome of RMN versus (vs.) MCN-CF ablation of AF with regards to AF recurrence. Secondary aim was to analyze periprocedural risk, ablation characteristics and repeat procedures.

Methods
We retrospectively analyzed 452 patients undergoing a total of 605 ablations of AF: 180 patients were ablated using RMN, 272 using MCN-CF.

Results
Except body mass index there was no significant difference between groups at baseline. After a mean 1.6 ± 1.6 years of follow-up and 1.3 ± 0.4 procedures, 81% of the patients in the MCN-CF group remained free of AF recurrence compared to 53% in the RMN group (P < 0.001). After analysis of 153 repeat ablations (83 MCN-RF vs. 70 RMN; P = 0.18), there was a significantly higher reconnection rate of pulmonary veins after RMN ablation (P < 0.001). In multivariable Cox-regression analysis, RMN ablation (P < 0.001) and left atrial diameter (P = 0.013) was an independent risk factor for AF recurrence. Procedure time, radiofrequency application time and total fluoroscopy time and fluoroscopy dose were higher in the RMN group without difference in total number of ablation points. Complication rates did not differ significantly between groups (P = 0.722).

Conclusions
In our retrospective comparative study, the AF recurrence rate and pulmonary vein reconnection rate is significantly lower with more favorable procedural characteristics and similar complication rate utilizing MCN-CF compared to RMN.
Downstaging after preoperative chemoradiation for locally advanced rectal cancer is associated with better survival than pathologic stage 0–1 disease treated with upfront surgery
Authors: Kasheri Eli , Artinyan Avo , Oka Kimberly , Zhu Ruoyan , Seiser Natalie , Shirinian Mihran , Barnajian Moshe , Cohen Jason , Ellenhorn Joshua , Nasseri Yosef 
Published: January 2024

Abstract
Background and objectives
It is unknown how patients with locally advanced rectal cancer with significant response to preoperative radiotherapy/chemoradiotherapy fare relative to patients with true pathologic 0–1 disease undergoing upfront surgery. We aimed to determine whether survival is improved in locally advanced rectal cancer downstaged to pathologic stage 0–1 disease compared to true pathologic stage 0–1 tumors.

Methods
A retrospective review of the National Cancer Database between 2004 and 2016 was conducted. Three groups were identified: (1) clinical stage 2–3 disease downstaged to pathologic stage 0–1 disease after radiotherapy, (2) clinical stage 2–3 disease not downstaged after radiotherapy, and (3) true pathologic 0–1 tumors undergoing upfront surgery. The primary endpoint was overall survival and was compared using Kaplan–Meier and multivariate Cox regression analyses.

Results
The study population consisted of 59,884 patients. Of the 40,130 patients with locally advanced rectal cancer treated with preoperative radiation, 12,670 (31.5%) had significant downstaging (group 1), while 27,460 (68.4%) had no significant downstaging (group 2). A total of 19,754 had pathologic 0–1 disease treated with upfront resection (group 3). On Kaplan–Meier analysis, downstaged patients had significantly better overall survival compared to both non-downstaged and true pathologic stage 0–1 patients (median 156 vs. 99 and 136 months, respectively, p < 0.001). On multivariate analysis, downstaged patients had significantly better survival (HR 0.88, p < 0.001) compared to true pathologic 0–1 patients.

Conclusions
Locally advanced rectal cancer downstaged after preoperative radiotherapy has significantly better survival compared to true pathologic stage 0–1 disease treated with upfront surgery. Response to chemoradiotherapy likely identifies a subset of patients with a particularly good prognosis.
The effect of a single closed-circuit rebreather decompression dive in extremely cold water to cardiac function
Authors: Tuominen Laura J. , Tuohinen Suvi , Lundell Richard V. , Räisänen-Sokolowski Anne K. , Wuorimaa Tomi 
Published: January 2024

Abstract
Purpose
Dive-induced cardiac and hemodynamic changes are caused by various mechanisms, and they are aggravated by cold water. Therefore, aging divers with pre-existing cardiovascular conditions may be at risk of acute myocardial infarction, heart failure, or arrhythmias while diving. The aim of this study was to assess the effect of a single decompression CCR dive in arctic cold water on cardiac function in Finnish technical divers.

Methods
Thirty-nine divers performed one identical 45 mfw CCR dive in 2–4 °C water. Hydration and cardiac functions were assessed before and after the dive. Detection of venous gas embolization was performed within 120 min after the dive.

Results
The divers were affected by both cold-water-induced hemodynamic changes and immersion-related fluid loss. Both systolic and diastolic functions were impaired after the dive although the changes in cardiac functions were subtle. Venous inert gas bubbles were detected in all divers except for one. Venous gas embolism did not affect systolic or diastolic function.

Conclusion
A single trimix CCR dive in arctic cold water seemed to debilitate both systolic and diastolic function. Although the changes were subtle, they appeared parallel over several parameters. This indicates a real post-dive deterioration in cardiac function instead of only volume-dependent changes. These changes are without a clinical significance in healthy divers. However, in a population with pre-existing or underlying heart problems, such changes may provoke symptomatic problems during or after the dive.
Comparison of the 7th and revised 8th UICC editions (2020) for oral squamous cell carcinoma: How does the reclassification impact staging and survival?
Authors: Struckmeier Ann-Kristin , Eichhorn Philip , Agaimy Abbas , Buchbender Mayte , Moest Tobias , Lutz Rainer , Kesting Marco 
Published: January 2024

AbstractSince its introduction in 1968, the TNM (tumor, node, metastasis) classification established by the International Union Against Cancer has provided a consistent framework for staging of oral squamous cell carcinoma (OSCC). The introduction of the 8th edition in 2017 brought about significant modifications, encompassing the integration of depth of invasion (DOI) and extranodal extension (ENE) into the T and N classifications. Further, the UICC the criteria for the T3 and T4a categories were amended in 2020. This study aimed to evaluate the impact of reclassification on staging and, subsequently, the survival of patients with OSCC. Primary OSCCs from 391 patients were classified according to the 7th and revised 8th UICC editions (2020). Stage migration was assessed, and stage-specific progression-free survival (PFS) and overall survival (OS) were evaluated using the Kaplan–Meier method. The log-rank test was used to compare the different stages. Cox-proportional hazard modeling was used to compare the two editions. Incorporating the DOI into the T classification resulted in an upstaging of 77 patients, constituting 19.69% of the cohort. In addition, 49 (12.53%) patients experienced an upstaging when considering ENE in the N classification. Consequently, 103 patients underwent upstaging in UICC staging, accounting for 21.74% of cases. Upstaging mainly occurred from stage III to IVA (26.92%) and from stage IVA to IVB (31.78%). Upon comparing the categories in survival analysis, significant differences in OS and PFS were especially observed between stage IVB and lower stages. When examining the hazard ratios, it became evident that UICC 8 stage IVB is burdened by a 5.59-fold greater risk of disease progression than stage I. Furthermore, UICC 8 stage IVB exhibits a 3.83 times higher likelihood of death than stage I disease. We demonstrated significant stage migration from the 7th to the revised 8th UICC edition. Overall, incorporating DOI and ENE into the T and N classifications represents a substantial clinical advancement, leading to a more accurate staging of OSCC patients. Both staging systems exhibited statistically significant discrimination between stages; however, the 8th UICC edition allowed for a more precise categorization of patients based on their prognosis and led to enhanced hazard discrimination, particularly within higher stages.
Adsorptive stripping voltammetric sensor based on Cd zeolitic imidazole framework-67 for electrochemical detection of sarin simulant
Authors: Elfiky Mona , Beltagi Amr M. , Abuzalat Osama 
Published: January 2024

AbstractA selective and reliable modified glassy carbon sensor, based on a 1.0% Cd zeolitic imidazole framework-67 modified glassy carbon sensor (GCS2), has been developed for ultrasensitive detection of dimethyl methyl phosphonate (DMMP) in human biological fluid. The synthesis of porous nanoparticles of Cd zeolitic imidazole framework-67 (Cd ZIF-67) was carried out via the hydrothermal method. The resulting Cd ZIF-67 powder emerges with good crystallinity, a rhombic dodecahedral morphology with particle size in the range 300 ~ 500 nm, and a specific surface area of 1780 m2·g−1. Furthermore, the fabricated sensor exhibited superior performance in the detection of DMMP with two linearity ranges of 0.02–2.0 nM and 2.0–9.0 nM and a limit of detection (LOD) of 0.06 pM. The fabricated sensor exhibited good reliability, long-term stability, and repeatability, which are favourable attributes for electroanalytical detection. In addition, the fabricated sensor displayed superior performance without significant interference during the assay of DMMP in a biological fluid (human serum sample) within two linearity ranges of 0.1–1.0 nM and 1.0–6.0 nM and a LOD of 0.03 nM.
Graphical Abstract
The spatiotemporal socio-demography of the Tokyo capital region: a data-driven explorative approach
Authors: Tateishi Eigo 
Published: January 2024

AbstractIn the coming decades, most of Asia’s population will reside in megacities, vast urban regions accommodating 10–30 million people. However, Asian megacities will be at the same time situated in the countries whose national population is projected to decline rapidly in the coming decades. Hence, for scholars and policymakers of Asian countries, understanding how the socio-demography of mature, post-growth, megacities will evolve within space and time is crucial to envision long-term and effective spatial governance. Prior studies have shown that varied migration patterns among socio-demographic groups lead to synchronized re-urbanization, post-suburbanization, and urban shrinkage in mature city regions. However, existing studies have limitations: they often exclude large Asian megacities, lack micro-scale analyses, and use predefined spatial typologies/divisions that obscure detailed patterns. To address these research gaps, this study investigated sub-municipal spatiotemporal patterns in Tokyo, the largest Asian megacity, using micro-scale job-household data and unsupervised machine learning clustering. The study revealed that Tokyo, like Euro-American cities, has experienced regional synchronization of (re)urbanization and (post)suburbanization within a complex landscape of shrinkage. However, the synchronized sub/urban growth is not uniform across localities within Tokyo. Complex migration flows seem to create disparities in demographic growth and decline, emphasizing the need for collaborative governance among localities within a megacity. The study contributes to a wider audience who are interested not only in the evolution of cities but also in an emerging application of machine learning to quantitative urban analyses.
Inflation and inequality: new evidence from a dynamic panel threshold analysis
Authors: Glawe Linda , Wagner Helmut 
Published: January 2024

AbstractThis paper investigates nonlinearities in the inflation-inequality relationship using a dynamic threshold panel data model and data for 101 countries over the period 1985–2020. We find that inflation rates exceeding 6% are associated with higher income inequality whereas below this threshold, the correlation remains insignificant. From a monetary policy perspective, these findings suggest that a disinflation policy will likely lead to a more equal income distribution in high-inflation countries whereas there is no such effect in a low-inflation setting. In addition, we find that a higher initial level of inequality as well as unemployment has an inequality-enhancing effect. Contrary to previous research, our inflation threshold is endogenously determined, and we control for the Nickell bias arising from the inclusion of the lagged level of inequality. Moreover, our paper covers a much longer time period and also a broader set of developed and developing countries. Our findings have important policy implications, especially against the background of the recent sharp increase in inflation.
Degradation increases peat greenhouse gas emissions in undrained tropical peat swamp forests
Authors: Swails Erin , Frolking Steve , Deng Jia , Hergoualc’h Kristell 
Published: January 2024

AbstractTropical peat swamp degradation can modify net peat greenhouse gas (GHG) emissions even without drainage. However, current Intergovernmental Panel on Climate Change (IPCC) guidelines do not provide default emission factors (EF) for anthropogenically-degraded undrained organic soils. We reviewed published field measurements of peat GHG fluxes in undrained undegraded and degraded peat swamp forests in Southeast Asia (SEA) and Latin America and the Caribbean (LAC). Degradation without drainage shifted the peat from a net CO2 sink to a source in both SEA (− 2.9 ± 1.8 to 4.1 ± 2.0 Mg CO2–C ha−1 yr−1) and LAC (− 4.3 ± 1.8 to 1.4 ± 2.2 Mg CO2–C ha−1 yr−1). It raised peat CH4 emissions (kg C ha−1 yr−1) in SEA (22.1 ± 13.6 to 32.7 ± 7.8) but decreased them in LAC (218.3 ± 54.2 to 165.0 ± 4.5). Degradation increased peat N2O emissions (kg N ha−1 yr−1) in SEA forests (0.9 ± 0.5 to 4.8 ± 2.3) (limited N2O data). It shifted peat from a net GHG sink to a source in SEA (− 7.9 ± 6.9 to 20.7 ± 7.4 Mg CO2-equivalent ha−1 yr−1) and increased peat GHG emissions in LAC (9.8 ± 9.0 to 24.3 ± 8.2 Mg CO2-equivalent ha−1 yr−1). The large observed increase in net peat GHG emissions in undrained degraded forests compared to undegraded conditions calls for their inclusion as a new class in the IPCC guidelines. As current default IPCC EF for tropical organic soils are based only on data collected in SEA ombrotrophic peatlands, expanded geographic representation and refinement of peat GHG EF by nutrient status are also needed.
Integrated analysis of diverse cancer types reveals a breast cancer-specific serum miRNA biomarker through relative expression orderings analysis
Authors: Ma Liyuan , Gao Yaru , Huo Yue , Tian Tian , Hong Guini , Li Hongdong 
Published: January 2024

Abstract
Purpose
Serum microRNA (miRNA) holds great potential as a non-invasive biomarker for diagnosing breast cancer (BrC). However, most diagnostic models rely on the absolute expression levels of miRNAs, which are susceptible to batch effects and challenging for clinical transformation. Furthermore, current studies on liquid biopsy diagnostic biomarkers for BrC mainly focus on distinguishing BrC patients from healthy controls, needing more specificity assessment.

Methods
We collected a large number of miRNA expression data involving 8465 samples from GEO, including 13 different cancer types and non-cancer controls. Based on the relative expression orderings (REOs) of miRNAs within each sample, we applied the greedy, LASSO multiple linear regression, and random forest algorithms to identify a qualitative biomarker specific to BrC by comparing BrC samples to samples of other cancers as controls.

Results
We developed a BrC-specific biomarker called 7-miRPairs, consisting of seven miRNA pairs. It demonstrated comparable classification performance in our analyzed machine learning algorithms while requiring fewer miRNA pairs, accurately distinguishing BrC from 12 other cancer types. The diagnostic performance of 7-miRPairs was favorable in the training set (accuracy = 98.47%, specificity = 98.14%, sensitivity = 99.25%), and similar results were obtained in the test set (accuracy = 97.22%, specificity = 96.87%, sensitivity = 98.02%). KEGG pathway enrichment analysis of the 11 miRNAs within the 7-miRPairs revealed significant enrichment of target mRNAs in pathways associated with BrC.

Conclusion
Our study provides evidence that utilizing serum miRNA pairs can offer significant advantages for BrC-specific diagnosis in clinical practice by directly comparing serum samples with BrC to other cancer types.
Cu/ZnO/CeO2 Supported on MOF-5 as a Novel Catalyst for the CO2 Hydrogenation to Methanol: A Mechanistic Study on the Effect of CeO2 and MOF-5 on Active Sites
Authors: Vali Seyed Alireza , Moral-Vico Javier , Font Xavier , Sánchez Antoni 
Published: January 2024

AbstractCu/ZnO/CeO2 nanocomposite was supported on metal organic framework (MOF-5) to enhance active sites dispersion and control the nanoparticles agglomeration during synthesis through strong metal-support interactions. The incorporation of MOF-5 alleviated the obstacle facing the commercial ternary Cu/ZnO/Al2O3 regarding low surface area due to nanoparticles agglomeration. In addition, Cu/ZnO/CeO2@MOF-5 gave higher methanol selectivity than the commercial catalyst which can be accounted for by the interfacial sites generated between MOF-5 and Cu/ZnO which favour methanol synthesis over carbon monoxide through regulating the intermediates bonding energies. CeO2 as support for Cu/ZnO nanoparticles was also compared with commercial support and showed to have led to smaller particle size and superior dispersion of Cu active sites as well. Cu/ZnO/CeO2@MOF-5 resulted in methanol STY of 23.3 mg gcat h−1 and selectivity of 79% at mild reaction temperature (260 °C) and pressure (10 bar). Two different MOFs including cerium based MOF and ZIF-8 demonstrated inferior performance compared to MOF-5.
Graphical Abstract
Measuring the Quality of Adult–Child Interactions in the Context of ECEC: a Systematic Review on the Relationship with Developmental and Educational Outcomes
Authors: Howard Steven J. , Lewis Kate L. , Walter Emma , Verenikina Irina , Kervin Lisa K. 
Published: January 2024

AbstractSubstantial research has aimed to characterise and measure early childhood education and care (ECEC) quality. However, heterogeneity in measures, methods and contexts across studies has made it difficult to reconcile the inconsistent associations reported between quality dimensions and child outcomes. While there is broad consensus that early interactions and experiences may be most strongly and directly influential to children’s developmental progress, attempts to identify aspects of quality interactions that relate most highly to child outcomes have tended to focus on particular measures and/or contexts. The aim of this systematical review was to reconcile the available evidence on associations of dimensions of quality interactions in formal ECEC settings (adult–child interactions and associated context and content) with the outcomes of children aged 3–5 years. Uniquely, this review examined how rates of significance differed by measure, country and study characteristics (e.g. sample, study design, risk of bias) – providing nuanced insights on quality indicators that most reliably account for children’s developmental progress. Seven databases were searched for the years 2000–2022, yielding 90 studies reporting 870 associations of interaction quality with various child development and educational outcomes. Results indicated little evidence for global ECEC quality indices (e.g. those integrating process quality indicators with structural elements) relating to child outcomes. The consistency in patterns of association improved for some dimensions of interaction quality (e.g. supporting play), with other dimensions showing low support even when they aligned with the outcome (e.g. instructional support with cognitive-academic outcomes). By providing an overview and reconciliation of evidence on the child-level associations in ECEC quality, across diverse measures and contexts, this review raises important questions of current ECEC quality assumptions and practices.