bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Diminutive Antenna employing identical elliptical notch in Elliptical Microstrip patch for multiband applications
Authors: Jat Nairaj , Gupta Manisha 
Published: October 2023

Abstract
The focus of discussion in this paper is an acceptable small configuration for an elliptical microstrip patch antenna. This is featured with planer geometry embedded mirror ellipse with elliptical notch layout. It can be used for multiband application in wireless communication. The chosen antenna produces seven echoing frequencies that operate across the frequency range of 5 to 18 GHz, including 5.9 GHz (use in WiMAX), 8.2 GHz, 9.99 GHz (use in X- band), 12.63 GHz (use in space services and within rise-data-rate), 13.97 GHz (land portable spacecraft, broadcast navigating implementation), 16.24 GHz and 17.57 GHz (use in Ku- band). The proposed antenna has mirror-imaged elliptical slots with embedded ellipse in slots having the microstrip signal line feed without any defects in the ground structure. A simulation tool that uses the finite element modelling set up (ex. CST) created the potential antenna. On a dual-sided FR-4 substrate (ɛᵣ = 4.3) with a layer thickness ‘h’ of 1.6 mm and a surface size (Ls× Ws) of 20 x 24 mm², the recommended antenna is modelled. The outcomes of the simulations show the fact that our presented antenna has satisfactory gain and S11 ≤ -10 dB input impedance bandwidths across seven working frequencies. This offered antenna design concept is a major contender for multiple purposes in wireless communication and is backed by resonant frequency regions spread throughout a broad spectrum.
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition
Authors: Guedan Sonia , Andreu-Saumell Irene , Rodriguez-Garcia Alba , Gimenez-Alejandre Marta , Castellsagué Joan , Mühlgrabner Vanessa , Brasó-Maristany Fara , Calderon Hugo , Marzal Berta , Colell Salut , Nuding Mara , Soria-Castellano Marta , Barbao Paula , Prat Aleix , Urbano-Ispizua Alvaro , Huppa Johannes 
Published: October 2023

Abstract

CAR-T cell therapy for solid tumors faces significant hurdles, including T-cell inhibition mediated by the PD-1/PD-L1 axis. The effects of disrupting this pathway on T-cells are being actively explored and controversial outcomes have been reported. Here, we hypothesize that CAR-antigen affinity may be a key factor modulating T-cell susceptibility towards the PD-1/PD-L1 axis. We systematically interrogated CAR-T cells targeting HER2 with either low (LA) or high affinity (HA) in various preclinical models. Our results revealed an increased sensitivity of LA CAR-T cells to PD-L1-mediated inhibition when compared to their HA counterparts by using in vitro models of tumor cell lines and supported lipid bilayers (SLB) modified to display varying PD-L1 densities. CRISPR/Cas9-mediated knockout (KO) of PD-1 enhanced LA CAR-T cell cytokine secretion and polyfunctionality in vitro and antitumor effect in vivo and resulted in downregulation of gene signatures related to T-cell exhaustion. By contrast, HA CAR-T cell features remained unaffected following PD-1 KO. This behavior held true for CD28 and ICOS but not 4-1BB co-stimulated CAR-T cells, which were less sensitive to PD-L1 inhibition. Our findings may inform CAR-T therapies involving disruption of PD-1/PD-L1 pathway tailored in particular for effective treatment of solid tumors.
High Solids Fibrillation of Cellulosic Fibers with and without Pretreatments through Planetary Ball Milling
Authors: Zhang Xiaoxue , Yelle Daniel , Kitin Peter , Tong Guolin , Zhu J. Y. 
Published: October 2023

Abstract
This study conducted a detailed evaluation of the feasibility of producing microfibrillated cellulose (MFC) from a kraft bleached hardwood pulp at high solids loadings with and without pretreatments. MFCs produced by planetary ball milling at solids loading at 17% and 28% were compared with those from 1% and 5% under the same milling conditions. Fiber pretreatments using a commercial endoglucanase and mechanical refining using a laboratory PFI mill were also applied before ball milling at solids loading of 28%. Two mechanisms of fiber fibrillation were identified from the results obtained: (i) ball and fiber/fibril interactions and (ii) inter-fiber/fibril frictional and tensional interactions. High solids loading with both mechanisms (i) and (ii) enhanced fiber fibrillation. A higher solids loading tends to result in a more uniformly fibrillated MFC than that from a lower solids loading run. Endoglucanase pretreatment substantially shortened fibers to result in a pulverized-like MFC with short fibrils at extended milling time. Mechanical refining of fibers facilitated fibrillation to result in MFCs with a morphology similar to that from fibers without any pretreatment but for a much shorter ball milling time. The insights gained through this study provides relevant information with commercial significance about MFC production at high solids, not available in the literature.
Silk gland morphology of the net-casting spider Deinopis spinosa
Authors: Correa-Garhwal Sandra M , Stafstrom Jay , Baker Richard H. , Hayashi Cheryl Y. , Hoy Ronald , Reeve Kern , Garb Jessica E. 
Published: October 2023

Abstract
Net-casting spiders (Deinopidae) are cribellate spiders that spin a rectangular, sticky net that is held stretched between the claws of their first two pairs of legs. Deinopids produce eight distinct silk types, but knowledge of the silk-producing morphologies is mostly limited to the spigots associated with different fibers. As there have been no studies of deinopid silk gland structure, we dissected all the silk glands from Deinopis spinosa and document their number and morphology. We found silk gland position and morphology consistent with the type and number of silk spigots described for Deinopidae. Notably, for the first time, we describe the silk glands associated with cribellate silk: paracribellate, pseudoflagelliform, and cribellar silk glands. Our findings support the homology of pseudoflagelliform glands with araneoid flagelliform glands and will have importance for informing our understanding of spider web evolution.
Causal association between physical activity and sedentary behavior and gestational diabetes mellitus: A Mendelian randomization analysis
Authors: Gao Jie , Liu Jingfang 
Published: October 2023

Abstract
Introduction Evidence of an association between physical activity (PA), sedentary behavior (SB) and gestational diabetes mellitus (GDM) remains controversial in observational studies, this study aimed to explore the causal association between PA, SB and GDM.
MethodsOur study performed Mendelian randomization (MR) analysis to explore the effects of three types of PA (moderate physical activity (MPA), moderate to vigorous physical activity (MVPA), accelerometer-based physical activity (ABPA)), three types of SB (television watching (TV), leisure computer use (PC), driving (DR)) on GDM and the mediating effect of body mass index (BMI). The inverse variance weighted method was used for the major analysis.
ResultsIn univariate MR analysis, we found that genetically predicted TV and PC among SB were associated with GDM (OR = 1.61, P = 0.001; OR = 0.71, P = 0.037), whereas, DR was not (OR = 1.68, P = 0.623). However, no association was found between physical activity and GDM: MPA (OR = 0.40, P= 0.273), MVPA (OR = 0.96, P = 0.861), and ABPA (OR = 0.99, P = 0.838). Multivariate MR analysis found that the causal effect of a 1 SD (1.5h) independently increase in the duration of TV was a 64% increase in the odds of GDM (OR = 1.64, P = 0.008) and that BMI was a mediating factor with a 62% mediating effect.
ConclusionsThis study demonstrated an independently causal association between TV and GDM, which is mediated by BMI, providing evidence for reducing the risk of GDM during pregnancy by reducing television watching time.
Corporate Wealth and Socioeconomic Conditions: How Globalization affects Domestic Economies
Authors: Mehar Muhammad Ayub Khan 
Published: October 2023

Abstract
Based on empirical pieces of evidence, this study supports globalization. It concludes that the use of the Internet, the arrival and departure of tourists, and the quantum of external trade play significant and robust roles in the alleviation of poverty, improving decent employment, reducing income inequalities, and improving domestic businesses. The major contribution of foreign direct investment is derived through improvement in local businesses. More importantly, information technology plays a substantial role in the progress of the domestic economy. Growth in merchandising trade improves GDP growth and alleviates vulnerable employment. Trade in services improves GDP growth and labor participation rate, while it alleviates poverty, unemployment, and inflation. The effectiveness of monetary policies has also been confirmed in this analysis. The panel least square techniques have been applied to estimate the effects of explanatory variables. This research is based on 14 years data (from 2008 to 2021) from 187 countries.
JEL Classification: E51, I32, J64, O21
Fulminant hepatitis revealing complicated Crohn’s disease of budd chiari syndrome:about a case
Authors: Belkhatir Amal , Hassaine Mahdi 
Published: October 2023

Abstract
The Budd-chiari syndrome (BCS) is a rare vascular disease of multifactorial etiopathogenesis, represents a serious thromboembolic complication of Crohn's disease(CD), and may be the revealing mode. This condition results from obstruction of hepatic venous drainage from the hepatic venules to the terminal part of the inferior vena cava, and can be primary or secondary. Here, we report a case of a young woman with fulminant hepatitis whose etiological diagnosis revealed Crohn's disease with acute budd chiari syndrome and who was successfully treated with anticoagulants associated with biotherapy. The patient had a very good clinical evolution, after three months total recovery from the BCS. Very few cases have been published on this association.
Perforation of the brachial artery during percutaneous lower extremity angioplasty via the brachial artery approach resulted in difficulties in balloon catheter removal: a case report
Authors: Yoshishige Yusuke , Kashima Katsuro , Arata Kenichi , Ooi Masaomi , Kawabata Kazuyo 
Published: October 2023

Abstract
Background Percutaneous endovascular treatment of peripheral vascular disease with small-caliber short sheaths may lead to device removal difficulties.
Case presentation A 50-year-old woman on hemodialysis underwent endovascular intervention for right common femoral artery stenosis, via the right brachial artery. A 4-F short sheath was used for the procedure owing to a previous hematoma at the puncture site. However, the balloon catheter could not cross the calcified lesion and was difficult to remove. A microcatheter was inserted and withdrawn, but the guidewire was kinked and could not be retrieved. Surgical retrieval of the guidewire and balloon catheter was performed. The kinked guidewire and microcatheter had migrated outside the vessel.
Conclusions In peripheral vascular intervention, the use of a long sheath in the brachial artery approach is important. Forcible removal of a difficult-to-remove catheter may cause further vascular damage. Therefore, it is essential to stop immediately and consider surgical treatment.
Nuclear sortilin controls genes involved in oncogenic pathways in lung adenocarcinoma
Authors: May Yassine , Lea Ikhlef , Boutaina Chandouri Faize , Heloise Daverat , Luc Negroni , Fabrice  Lalloue , Thomas Naves 
Published: October 2023

Abstract
Sortilin, a glycoprotein belonging to the Vps10 family, is mainly recognized for its contribution to protein sorting. Its dichotomous role in oncology, between tumor promotion and suppression, remains highly controversial. Our present study reveals a novel mechanism relying on the nuclear localization of sortilin, acting on transcription, chromatin reorganization and DNA repair. Its role in limiting tumor progression of lung adenocarcinoma cell lines was confirmed with sustained EGFR proliferative signaling. Furthermore, we report that sortilin overexpression limits the growth of NCI-H1975 and NCI-H3255 cell lines, regulating gene expression but also indirectly altering oncogenic pathways such as MTOR and AKT. Through its transcriptional action, sortilin interacts directly with proteins central to DNA repair mechanisms and chromatin reorganization. Finally, our findings reshape the traditional view of sortilin, suggesting implications not restricted to its simple protein transport, which contributes to explain its heterogeneous roles in different tumors. These insights also position sortilin as a promising candidate to engineer innovative therapeutics in lung adenocarcinoma.
„Widerstand mit vielleicht veralteten Mitteln“
Authors: Wintersteiner Werner 
Published: October 2023

Dieser Text versucht, die politische Dimension von Deutschunterricht und Deutschdidaktik systematisch und historisch zu erfassen. Die Beschäftigung mit Sprache, Literatur und Medien ist eine naturgemäß politische Angelegenheit. Das Politische sollte jedoch nicht nur als Inhalt des Unterrichts, sondern als Herausforderung für das Selbstverständnis des Faches verstanden werden. Das Politische ist kein spezielles Arbeitsfeld des Deutschunterrichts, wie z. B. das Barock oder die Textgrammatik. Das Politische ist eine Dimension aller Arbeitsfelder.
Der Deutschunterricht verdankt historisch gesehen politischen Zielsetzungen seinen Aufstieg als Leitfach im schulischen Fächerkanon. Die moderne Deutschdidaktik hat sich wiederum in den 1970er Jahren in explizit politischer Absicht von der Deutschmethodik abgesetzt. Deswegen wird zunächst ein Blick auf die Anfänge der Disziplin in den 1960er und 1970er Jahren geworfen. In einem weiteren Anlauf werden heutige Herausforderungen durch Globalisierung, Postkolonialismus und die aktuelle Polykrise erörtert, und es wird für einen Paradigmenwechsel plädiert. Der Text endet mit einigen Hinweisen auf eine politisch verstandene Literaturdidaktik.
The fate of sulfamethoxazole and trimethoprim in a micro-aerated anaerobic membrane bioreactor and the occurrence of antibiotic resistance in the permeate
Authors: Piaggio Antonella , Mittapalli Srilekha , Calderón-Franco David , Weissbrodt David , van Lier Jules , de Kreuk Merle , Lindeboom Ralph 
Published: October 2023

Abstract

This study investigates the effects, conversions, and resistance induction, following the addition of 150 μg·L−1 of two antibiotics, sulfamethoxazole (SMX) and trimethoprim (TMP), in a laboratory-scale micro-aerated anaerobic membrane bioreactor (MA-AnMBR). TMP and SMX were removed at 97 and 86%, indicating that micro-aeration did not hamper their removal. These antibiotics only affected the pH and biogas composition of the process, with a significant change in pH from 7.8 to 7.5, and a decrease in biogas methane content from 84 to 78%. TMP was rapidly adsorbed onto the sludge and subsequently degraded during the long solids retention time of 27 days. SMX adsorption was minimal, but the applied hydraulic retention time of 2.6 days was sufficiently long to biodegrade SMX. The levels of three antibiotic-resistant genes (ARGs) (sul1, sul2, and dfrA1) and one mobile genetic element biomarker (intI1) were analyzed by qPCR. Additions of the antibiotics increased the relative abundances of all ARGs and intI1 in the MA-AnMBR sludge, with the sul2 gene folding 15 times after 310 days of operation. The MA-AnMBR was able to reduce the concentration of antibiotic-resistant bacteria (ARB) in the permeate by 3 log.
Gastrointestinal Tract and Kidney Injury Pathogenesis in Post-COVID-19 Syndrome
Authors: Marzoog Basheer Abdullah 
Published: October 2023

Abstract:
COVID-19 is a global health emergency that requires worldwide collaboration to control
its spread. The scientific community is working to understand the different aspects of the
post-COVID-19 syndrome and potential treatment strategies. Interestingly, there have been reports
of gastrointestinal tract (GIT) involvement in the post-COVID-19 syndrome, suggesting
the presence of both severe and mild GIT disorders. The development of the post-COVID-19-
GIT syndrome involves various factors, such as impaired GIT mucosa cells, disruptions in the
feeling of satiety, reduced blood supply due to the formation of small blood clots, and increased
prostaglandin secretion caused by an excessive immune response. GIT symptoms have been observed
in around 16% of COVID-19 patients. Other complications include kidney damage and
prolonged impairment in the filtration and excretion functions of the glomeruli and tubules. The
pathogenesis of post-COVID-19 renal syndrome involves factors, like an overactive immune response,
reduced lung perfusion and oxygenation, viral infection in kidney tissues, endothelial
dysfunction, and decreased blood volume. Roughly 20% of hospitalized patients experience renal
manifestations after recovering from COVID-19.
THE RISK OF BURNOUT SYNDROME IN SPEECH-LANGUAGE PATHOLOGISTS IN THE REPUBLIC OF SERBIA
Authors: Jerkić Rajić Lana , Zelić Mirna , Milisavljević Jelena , Mentus Kandić Tatjana , Strižak Nevena , Obrenović Ilić Ivana 
Published: October 2023

Burnout is a current topic which many researchers are dealing with. This syndrome is most commonly considered to occur in people who are engaged in ‘helping professions’. Since speech-language pathologists belong to the helping professions, the goal of this study was to assess the extent to which burnout symptoms are present among speech-language pathologists in the Republic of Serbia. The sample of this research included 150 speech-language pathologists employed in state institutions and private centres throughout the Republic of Serbia. The assessment of burnout symptoms was performed using the Maslach Burnout Inventory – Human Services Survey (MBI-HSS), which measures three different dimensions: emotional exhaustion, depersonalisation, and personal achievement. The use of statistical procedures confirmed the majority of the research hypotheses. This population displays burnout symptoms, which are usually low (on the Depersonalisation and Personal Achievement scales) or high (Emotional Exhaustion) in degree. According to the findings of this study, while older speech-language pathologists report a high level of emotional exhaustion, they also report a higher level of personal achievement. Respondents with more work experience report a greater level of exhaustion. Lower levels of emotional weariness and a lower degree of personal achievement were reported by speech-language pathologists with less work experience. Satisfaction with one’s level of income was found to be the most significant predictor of burnout symptoms. Marital status and the number of children have not been associated with burnout symptoms.
Educación en geriatría en México: Revisión del escenario educativo actual en médicos en formación (EDUREV)
Authors: Gómez-Moreno Carolina , Perez-Mendez Ayari , Hernández-Murillo Ana María , Ortega-Ortiz Corina , Cortés-Hernàndez Nancy Cecilia , Ávila-Funes José Alberto , Gutiérrez-Cirlos Carlos 
Published: October 2023

Introducción: En México existe una cantidad inadecuada de profesionales en salud con una buena capacidad de atención de las personas mayores. Uno de los factores modificables para mejorar esta situación, son las intervenciones educativas que puedan implementarse en etapas formativas; sin embargo, no existe información actualizada de la enseñanza de geriatría en medicina en México.
Objetivo: Revisar y registrar si existe la materia de geriatría en los programas educativos de medicina en universidades mexicanas y describir las características de la misma, para elaborar un reporte actualizado de la enseñanza de geriatría en México.
Método: Estudio descriptivo de muestreo por conveniencia. Se realizó una encuesta a las escuelas y facultades de medicina certificadas por el Consejo Mexicano para la Acreditación de la Educación Médica (COMAEM), mediante un formato virtual. La información que no se respondió directamente por las escuelas, se obtuvo a partir de los sitios web de estas.
Resultados: Se encontró que un 88% de las escuelas de medicina certificadas por la COMAEM tiene contenido de geriatría. El contenido es obligatorio en un 99% de los casos evaluados. Un 56% de las escuelas imparte el contenido de manera exclusivamente teórica y 41% de manera teórico-práctica. Un 7% de los docentes que imparten el contenido reportó no tener ninguna formación en geriatría.
Conclusiones: Hay avances en la difusión de la información de geriatría. Las metas serán lograr la totalidad de las escuelas con contenido y buscar uniformidad en el mismo.
Nivel de inteligencia emocional y empatía en médicos residentes
Authors: Fernández Vázquez María Urbelina , Sánchez Torres Rosa Ivonne 
Published: October 2023

Introducción: La inteligencia emocional es una competencia blanda que, está demostrado, influye en la capacidad de las personas para tener éxito al hacer frente a las demandas y presiones ambientales. Por otro lado, la empatía tiene un papel importante porque es un atributo cognitivo que engloba el entendimiento de experiencias y perspectivas del individuo. Ambas con beneficios en la relación médico-paciente, pues consigue un mejor diagnóstico y mayor apego a los tratamientos.
Objetivo: Evaluar el nivel de inteligencia emocional y empatía que poseen los médicos residentes de la delegación Puebla del IMSS.
Método: Estudio cuantitativo, analítico, longitudinal, homodémico, prospectivo y multicéntrico. Participaron 254 médicos residentes de 12 especialidades, se utilizaron como instrumentos de medición: la escala TMSS 24 para inteligencia emocional y la escala de Jefferson para la empatía.
Resultados: Se tuvo más participación del sexo femenino, con una edad promedio global de 29 años, la mayor participación fue de la especialidad en medicina familiar. En los rubros atención, claridad y reparación de la inteligencia emocional, el resultado fue adecuado con 48%, 53.9% y 61.8%, respectivamente. En la escala de empatía de Jefferson predominó el rubro sobresaliente con un 46.8%. Se identificó a 19 médicos residentes con niveles bajos en cada una de las dimensiones de la inteligencia emocional aunado a una empatía intermedia y baja.
Discusión: los niveles de inteligencia emocional y de empatía fueron adecuados, aunque los médicos residentes con niveles bajos en ambos rubros representan un foco rojo y un área de oportunidad para la educación emocional.
Conclusiones: La inteligencia emocional y la empatía son habilidades que los médicos residentes deben poseer porque tienen beneficios para ellos y para sus pacientes, por lo que es importante fomentar la enseñanza de estas habilidades desde los años formativos.
Ley Constitutiva de la Universidad Nacional de México
Authors: Nacional de México Ley Constitutiva de La Universidad 
Published: October 2023

Presentamos esta nueva sección de la Revista que se dedica a presentar importantes documentos Universitarios que han ido edificando la historia y estructura contemporánea de nuestra Alma Mater. En esta ocasión corresponde difundir el Decreto Fundacional de la entonces Universidad Nacional de México, nacida en 1910.
Este documento fue consultado en la página oficial de la Abogacía General de la Universidad Nacional Autónoma de México (UNAM).