bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychology-based cohesion education & drug effects on depressed college students
Authors: Deng Xiaojun , Liu Qiang 
Published: October 2023

BackgroundThe prevalence of depression is increasing among students in higher education due to academic stress and interpersonal relationships. Although medication is the main form of intervention, medication alone may not achieve the desired results. Recently, cohesion education based on educational psychology has received attention and is considered as a possible effective non-pharmacological treatment.Subjects and MethodsThree hundred college and university students who had been diagnosed with depression were selected for the study. They were randomly divided into three groups: a medication group, a cohesion education combined with medication group, and a control group. Among them, cohesion education covered teamwork, group activity organisation, and interactive communication skills, which lasted for six months, once a week for two hours. All groups received conventional medication for depression. Students were assessed for depressive symptoms before, during and after the intervention using the Hamilton Depression Rating Scale (HDRS).ResultsHDRS scores in the cohesive education combined medication group were significantly lower than those in the medication and control groups at the end of the study. In addition, students in the combined treatment group generally reported that their interpersonal relationships improved and their teamwork skills increased.ConclusionsCohesive education based on educational psychology combined with medication has significant efficacy for students with depression in colleges and universities. This combined treatment not only helps to reduce students’ depressive symptoms, but also improves their interpersonal relationships and teamwork skills.Acknowledgement
2016 Middle-aged and Youth Research Project of Fujian Provincial Department of Education (No. JAS160604).
Psychological development on the positive psychology of autistic students
Authors: Hao Xiaofan 
Published: October 2023

BackgroundAutism is a neurodevelopmental disorder characterized by social interaction and verbal communication deficits. Students with autism face various psychological difficulties in the college environment, such as social difficulties, emotional fluctuations, and limited cognitive function. This study aims to help autistic students develop their psychology and improve their quality of life.Subjects and MethodsThis study tried to carry out psychological extension training in college sports, and 50 students with autism were set as research objects. Half of the students received psychological extension training in the physical education course, and the other half received traditional behavioral intervention therapy in the physical education course. Both groups of students received one semester of therapeutic training. Results SPSS23.0 software was used for psychological data correlation statistics, P>0.5 indicated strong correlation and P<0.5 indicated medium weak correlation.Results
The experimental results showed that after one semester of treatment training, the number of autistic students in the experimental group was reduced to 12. The overall mental state was good, and the cultivation of positive psychology was more effective. At the same time, the average test score was higher. However, the number of students with autism in the control group remained high at about 20, and the P-value was still greater than 0.5.ConclusionsThe psychological development training proposed in this study can provide theoretical and practical guidance for cultivating autistic students’ positive psychology to improve their overall mental health level.
Helicopter Rotors
Authors: McClements A 
Published: October 2023

Ladies and Gentlemen,It is with pleasure that I introduce to you today MR MCCLEMENTS, who is going to talk to us on the subject of “Helicopter Rotors”MR McCLEMENTS is a relatively newcomer to the rotary wing industry and only claims a modest two years or so of direct connection, first with the Ministry of Supply and now as experimental engineer to the Helicopter Development Unit of British European Airways Corporation Apart from this, it is quite obvious that he has given a great deal of thought and work to the subject of his lectureSpeaking from personal experience, I can assure you that he was invaluable to all those in the industry during his time at the Ministry of Supply and will, I am sure, be equally so in his present appointmentOn behalf of the Association, may I welcome our guests and trust you will be well rewarded for coming along
The Operational Point of View
Authors: Brie R A C 
Published: October 2023

Although barely two years have elapsed since the helicopter was first certificated for civil use, the problem associated with its operation are sufficiently well defined to enable their nature to be discussed with reasonable facility Actually, of course, there are twenty-six years, including many tens of thousands of flying hours behind this particular development, and it is quite logical therefore that the most advanced and successful type of helicopter to date embodies the basic and well proven rotor features of the Cierva AutogiroThere is still much to learn, however, and at this stage of development it has in many ways been advantageous that, so far, the field of operational use has been a professional one Difficulties have been minor rather than of a major category, but circumstances could easily have been otherwise had there not been constantly available the requisite background of skill and experience not only to cure, but what is of equal importance, to anticipate and prevent trouble before it could assume proportions of a serious nature Additionally the limited number of helicopters in use has encouraged and made possible a rather intimate and desirable liaison between constructor and operator, which in turn has given the aircraft a reasonable opportunity to establish itself and prove its value under strictly controlled conditions of inspection and operation
The Bristol 171 Helicopter
Authors: Hafner Raoul 
Published: October 2023

The technical problems confronting the helicopter designer are very clearly enumerated in Captain LIPTROT’s paper, and Wing Commander BRIE has drawn attention to a number of considerations of importance to the operatorWith some of these problems I have dealt in an earlier paper, and in order to avoid repetition I propose to leave out from this discussion points which have already been raisedRotating-wing aircraft in forward flight are subject to vibrations for reasons which are fundamental and we must not therefore expect the elimination of these symptoms but only their reduction to generally tolerable proportions We need, therefore, more accurate methods of recording and analysing vibrations in helicopters in terms of component frequencies and amplitudes, and in addition we must have generally agreed standards for comfort, i e, limiting vibration levels as a yardstick both to makers and users of these aircraft
Helicopter Operations—Some Problems and Prospects
Authors: Rowe N E 
Published: October 2023

Ladies and GentlemenThe Paper we are about to hear this afternoon is obviously of very great importance to manufacturers and potential operators, and no less to all of us who have the interest of helicopters at heart It is quite reasonable to suppose that the more we know of the problems of operation, the more likely we are to produce the right type of helicopter for the jobIt would be difficult to think of anyone better qualified to give this paper than our lecturer to-day, and we are very much honoured that so eminent a gentleman should do so MR ROWE is a Fellow and a Vice President of the Royal Aeronautical Society, has had a varied and distinguished aeronautical scientific career, and was Director General of Technical Development at the Ministry of Aircraft Production in 1945 His present appointment is that of Controller of Long Term Research and Development with British European Airways Corporation, in which capacity he is intimately concerned with the problems of helicopter operation, both present and future
Some Present and Future Aspects of Helicopter Piloting
Authors: Fay J S 
Published: October 2023

Introducing Captain FAY, MR FITZWILLIAMS said it would be generally agreed, that very few people, if any, in the world were better able to discuss the subject The lecturer held the rank of Captain in British European Airways, and had served with the Helicopter Unit of the B E A since its inception in 1947, when it was based on Yeovil, and when the Chairman had had the pleasure of meeting him and his colleagues The activities of that Unit had covered a very wide range of helicopter operation, including an intensive pioneering effort in helicopter blind flyingAs a Fleet Air Arm pilot he had learned to fly in 1940, and had served for two years in H M S “Victorious” Afterwards he had joined the Naval Service Trials Unit, and was converted to helicopters at the first helicopter training course in this country, at Hanworth, in 1944
Rotor Stations—The Scheduled Operator’s Viewpoint
Authors: Whitby R H 
Published: October 2023

When first I heard that I was to be asked to give this Paper to the Association, one of those present asked me what I knew about Rotor Stations I had to admit that it was very little Some of the remarks I shall make in the paper will seem so obvious as to appear platitudes Others, particularly those relating to the dimensions of the landing area, are offered in the absence of a significant amount of directly applicable data and may be treated as one individual’s guess In these circumstances, the discussion which follows should be of even greater importance relative to the Paper than is normally the case in our meetingsA Rotor Station can be viewed from a number of standpoints Those of the public user, the town planning authority and the civil-engineer-architect will be dealt with by other speakers I propose to look at it from the standpoint of the scheduled operator
A Review of Helicopter Patents
Authors: Haywood L H 
Published: October 2023

The CHAIRMAN, introducing the author, said Mr HAYWARD IS a member of the Helicopter Association of Great Britain He is a Bristol man, having been educated m that city, and later he served a five-year apprenticeship with the Bristol Aeroplane Company, Limited He served for some time on the technical staff of D Napier & Son, returning to The Bristol Aeroplane Company in 1945, and from there joined the Fairey Aviation Company as Patent EngineerThe title of Mr Hayward's paper is, I think, deceptive, for not only does he give a comprehensive review of the helicopter patent situation, but m addition almost a complete history of the helicopter through the ages, from Leonardo da Vinci to present day developments in the propulsion of helicopter rotors by jet motor
Early Test Flights in the Bristol 173 Helicopter
Authors: Hosegood C T D 
Published: October 2023

I must depart at once from my script to thank Wing Commander BRIE for his kind introduction, and add that with such a formidable array before me my immediate reaction is to take refuge in a corner and re-write much of my little paper packing it with graphs, square roots and at least a mention of omega However, time does not permit thisAs you know, this is a short paper outlining some experiences that have come my way while testing helicopters I hope I have been able to strike the right note, and that in my avoidance of “digging up” technical data and figures, the general facts are not too woolly
Problems of Helicopter Operation peculiar to Shipboard Use
Authors: Spedding H R 
Published: October 2023

This paper deals solely with the operation of helicopters from ships in the Royal NavySince the great majority of helicopter flying at sea has been carried out from aircraft carriers, I propose first to deal with these operations, and secondly I shall describe a series of trials carried out in 1950 to determine the feasibility of operating from a specially constructed platform on a merchant type vesselAs an introduction I should like to give a brief history of the helicopter in the Royal NavyIn 1943 a small number of pilots were sent to the United States to learn the principles of Rotary Wing flying and on their return to this country a flight was formed equipped with Sikorsky R 4 machines Its task was to carry out communication, photographic and radar calibration duties
The Independent Operator and the Helicopter
Authors: Rees Ivor Jones 
Published: October 2023

SummaryThe paper describes some of the overseas operations which have been conducted by AIRWORK LIMITED in the last eight years and in places ranging from South America via the Middle East to New Zealand It examines some of the problems that have to be faced by an overseas operator, and suggests the possibility of using helicopters for certain of the work which is now earned out by fixed wing aircraft It concludes that providing certain conditions as to performance and operating cost can be met there is a definite place for the helicopter in such overseas operations
Nicotine pouches: a review for the dental team
Authors: M. Jackson Joshua , Weke Anthony , Holliday Richard 
Published: October 2023

AbstractNicotine pouches are tobacco-free products that are becoming increasingly popular in the UK. They are held between the user's lip and gum to provide a source of nicotine. This article describes the composition of nicotine pouches, the legality surrounding their production and sale, patterns of use and explores possible oral and general health effects of their usage.
FOXO family isoforms
Authors: Santos Bruno F. , Grenho Inês , Martel Paulo J. , Ferreira Bibiana I. , Link Wolfgang 
Published: October 2023

AbstractFOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell maintenance, cancer, metabolic, and cardiovascular diseases. Genetic evidence has been accumulating to suggest a prominent role of FOXOs in lifespan regulation in animal systems from hydra, C elegans, Drosophila, and mice. Together with the observation that FOXO3 is the second most replicated gene associated with extreme human longevity suggests that pharmacological targeting of FOXO proteins can be a promising approach to treat cancer and other age-related diseases and extend life and health span. However, due to the broad range of cellular functions of the FOXO family members FOXO1, 3, 4, and 6, isoform-specific targeting of FOXOs might lead to greater benefits and cause fewer side effects. Therefore, a deeper understanding of the common and specific features of these proteins as well as their redundant and specific functions in our cells represents the basis of specific targeting strategies. In this review, we provide an overview of the evolution, structure, function, and disease-relevance of each of the FOXO family members.
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases
Authors: Smith Ruben , Capotosti Francesca , Schain Martin , Ohlsson Tomas , Vokali Efthymia , Molette Jerome , Touilloux Tanja , Hliva Valerie , Dimitrakopoulos Ioannis K. , Puschmann Andreas , Jögi Jonas , Svenningsson Per , Andréasson Mattias , Sandiego Christine , Russell David S. , Miranda-Azpiazu Patricia , Halldin Christer , Stomrud Erik , Hall Sara , Bratteby Klas , Tampio L’Estrade Elina , Luthi-Carter Ruth , Pfeifer Andrea , Kosco-Vilbois Marie , Streffer Johannes , Hansson Oskar 
Published: October 2023

AbstractA positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro affinity and specificity for pathological α-synuclein in tissues from patients with different α-synuclein-related disorders including Parkinson’s disease (PD) and Multiple-System Atrophy (MSA) using autoradiography and radiobinding techniques. In the initial clinical evaluation we include 23 participants with α-synuclein related disorders, 11 with other neurodegenerative disorders and eight controls. In vivo [18F]ACI-12589 demonstrates clear binding in the cerebellar white matter and middle cerebellar peduncles of MSA patients, regions known to be highly affected by α-synuclein pathology, but shows limited binding in PD. The binding statistically separates MSA patients from healthy controls and subjects with other neurodegenerative disorders, including other synucleinopathies. Our results indicate that α-synuclein pathology in MSA can be identified using [18F]ACI-12589 PET imaging, potentially improving the diagnostic work-up of MSA and allowing for detection of drug target engagement in vivo of novel α-synuclein targeting therapies.
Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling
Authors: Soya Naoto , Xu Haijin , Roldan Ariel , Yang Zhengrong , Ye Haoxin , Jiang Fan , Premchandar Aiswarya , Veit Guido , Cole Susan P. C. , Kappes John , Hegedüs Tamás , Lukacs Gergely L. 
Published: October 2023

AbstractThe folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide binding domains (NBD1,2) and transmembrane domains (TMD1,2). Using molecular dynamic simulations, biochemical and hydrogen deuterium exchange approaches, we show that the mutational uncoupling or stabilization of NBD1-TMD1/2 interfaces can compromise or facilitate the CFTR(ABCC7)-, MRP1(ABCC1)-, and ABCC6-transporters posttranslational coupled domain-folding in the endoplasmic reticulum. Allosteric or orthosteric binding of VX-809 and/or VX-445 folding correctors to TMD1/2 can rescue kinetically trapped CFTR posttranslational folding intermediates of cystic fibrosis (CF) mutants of NBD1 or TMD1 by global rewiring inter-domain allosteric-networks. We propose that dynamic allosteric domain-domain communications not only regulate ABCC-transporters function but are indispensable to tune the folding landscape of their posttranslational intermediates. These allosteric networks can be compromised by CF-mutations, and reinstated by correctors, offering a framework for mechanistic understanding of ABCC-transporters (mis)folding.
Energy-efficient CO2/CO interconversion by homogeneous copper-based molecular catalysts
Authors: Guria Somnath , Dolui Dependu , Das Chandan , Ghorai Santanu , Vishal Vikram , Maiti Debabrata , Lahiri Goutam Kumar , Dutta Arnab 
Published: October 2023

AbstractFacile conversion of CO2 to commercially viable carbon feedstocks offer a unique way to adopt a net-zero carbon scenario. Synthetic CO2-reducing catalysts have rarely exhibited energy-efficient and selective CO2 conversion. Here, the carbon monoxide dehydrogenase (CODH) enzyme blueprint is imitated by a molecular copper complex coordinated by redox-active ligands. This strategy has unveiled one of the rarest examples of synthetic molecular complex-driven reversible CO2reduction/CO oxidation catalysis under regulated conditions, a hallmark of natural enzymes. The inclusion of a proton-exchanging amine groups in the periphery of the copper complex provides the leeway to modulate the biases of catalysts toward CO2 reduction and CO oxidation in organic and aqueous media. The detailed spectroelectrochemical analysis confirms the synchronous participation of copper and redox-active ligands along with the peripheral amines during this energy-efficient CO2reduction/CO oxidation. This finding can be vital in abating the carbon footprint-free in multiple industrial processes.
Coral endosymbiont growth is enhanced by metabolic interactions with bacteria
Authors: Matthews Jennifer L. , Khalil Abeeha , Siboni Nachshon , Bougoure Jeremy , Guagliardo Paul , Kuzhiumparambil Unnikrishnan , DeMaere Matthew , Le Reun Nine M. , Seymour Justin R. , Suggett David J. , Raina Jean-Baptiste 
Published: October 2023

AbstractBacteria are key contributors to microalgae resource acquisition, competitive performance, and functional diversity, but their potential metabolic interactions with coral microalgal endosymbionts (Symbiodiniaceae) have been largely overlooked. Here, we show that altering the bacterial composition of two widespread Symbiodiniaceae species, during their free-living stage, results in a significant shift in their cellular metabolism. Indeed, the abundance of monosaccharides and the key phytohormone indole-3-acetic acid (IAA) were correlated with the presence of specific bacteria, including members of the Labrenzia (Roseibium) and Marinobacter genera. Single-cell stable isotope tracking revealed that these two bacterial genera are involved in reciprocal exchanges of carbon and nitrogen with Symbiodiniaceae. We identified the provision of IAA by Labrenzia and Marinobacter, and this metabolite caused a significant growth enhancement of Symbiodiniaceae. By unravelling these interkingdom interactions, our work demonstrates how specific bacterial associates fundamentally govern Symbiodiniaceae fitness.
Dopant-assisted stabilization of negatively charged single nitrogen-vacancy centers in phosphorus-doped diamond at low temperatures
Authors: Geng Jianpei , Shalomayeva Tetyana , Gryzlova Mariia , Mukherjee Amlan , Santonocito Santo , Dzhavadzade Dzhavid , Dasari Durga Bhaktavatsala Rao , Kato Hiromitsu , Stöhr Rainer , Denisenko Andrej , Mizuochi Norikazu , Wrachtrup Jörg 
Published: October 2023

AbstractCharge state instabilities have been a bottleneck for the implementation of solid-state spin systems and pose a major challenge to the development of spin-based quantum technologies. Here we investigate the stabilization of negatively charged nitrogen-vacancy (NV−) centers in phosphorus-doped diamond at liquid helium temperatures. Photoionization of phosphorous donors in conjunction with charge diffusion at the nanoscale enhances NV0 to NV− conversion and stabilizes the NV− charge state without the need for an additional repump laser. The phosphorus-assisted stabilization is explored and confirmed both with experiments and our theoretical model. Stable photoluminescence-excitation spectra are obtained for NV− centers created during the growth. The fluorescence is continuously recorded under resonant excitation to real-time monitor the charge state and the ionization and recombination rates are extracted from time traces. We find a linear laser power dependence of the recombination rate as opposed to the conventional quadratic dependence, which is attributed to the photo-ionization of phosphorus atoms.
Myofascial urinary frequency syndrome is a novel syndrome of bothersome lower urinary tract symptoms associated with myofascial pelvic floor dysfunction
Authors: Ackerman A. Lenore , Jackson Nicholas J. , Caron Ashley T. , Kaufman Melissa R. , Routh Jonathan C. , Lowder Jerry L. 
Published: October 2023

AbstractThis study describes a novel, distinct phenotype of urinary symptoms named “myofascial urinary frequency syndrome” (MUFS) present in one-third of individuals presenting with urinary frequency. In addition to a characteristic symptom constellation suggestive of myofascial dysfunction, MUFS subjects exhibit “persistency”: a persistent feeling of needing to urinate regardless of urine volume. On examination, 97% of MUFS patients demonstrated pelvic floor hypertonicity with either global tenderness or myofascial trigger points, and 92% displayed evidence of impaired muscular relaxation, hallmarks of myofascial dysfunction. To confirm this symptom pattern was attributable to the pelvic floor musculature, we confirmed the presence of “persistency” in 68 patients with pelvic floor myofascial dysfunction established through comprehensive examination and electromyography and corroborated by improvement with pelvic floor myofascial release. These symptoms distinguish subjects with myofascial dysfunction from subjects with OAB, IC/BPS, and asymptomatic controls, confirming MUFS is a distinct LUTS symptom complex.