bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracellular Regulation Limits the Response of Intestinal Ferroportin to Iron Status in Suckling Rats
Authors: Qiu Lili , Hu Mengxiao , Qin Xiyu , Song Rui , Sun Yanan , Wang Xiaoyu 
Published: February 2024

ScopeIron status is regulated via iron absorption as there is no active iron excretion. Divalent metal‐ion transporter‐1 (DMT1) and ferroportin (FPN) are two key proteins vital for iron absorption, but the regulation of them in suckling mammals differs from that in adults. This study aims to explore regulation of iron transporters under different iron conditions during suckling.Methods and resultsThis study developed suckling rats under different iron conditions. Unexpectedly, unchanged FPN at different iron status are detected. Since FPN is the only known iron exporter for mammals, unchanged FPN limits iron exported into blood during suckling. Thus, factors regulating FPN at transcriptional, post‐transcriptional, and post‐translational levels are detected. Results showed that Fpn mRNA is upregulated, while micro RNA‐485(miR‐485) which could silence Fpn mRNA is upregulated at low iron status limiting translation of Fpn mRNA. Besides, serum hepcidin and liver Hamp mRNA are upregulated, but ring finger protein 217( Rnf217) mRNA remained unchanged at high iron status leading to FPN not downregulated as adults.ConclusionsOverall, this study indicates that translational regulation limits intestinal FPN protein response to iron deficiency and Rnf217 cannot effectively mediate the degradation of FPN at high iron status, which provides a reference for maintaining iron homeostasis during suckling.
A wide locking range injection‐locked frequency divider with an auto‐adjusted injection bias
Authors: Lv Jingjing , Wu Yajie , Du Li , Du Yuan 
Published: February 2024

AbstractThis paper presents a Ku‐band divide‐by‐2 direct injection‐locked frequency divider (ILFD) with a wide locking range (LR) and high input sensitivity. The proposed ILFD incorporates an auto‐adjusted injection bias that uses a power detector (PD) to convert the power of the injected signal to a DC voltage. The bias voltage of the injection transistor is then auto‐adjusted in response to the output of the PD. The proposed ILFD employs a 2‐bit switched capacitor array to further enhance the entire LR. Implemented in a 65‐nm CMOS process, the experimental results show that the proposed ILFD achieves an LR of 62.3% (10.5–20 GHz) and 51.2% (11.2–18.9 GHz) at 0 and −10 dBm injection power, respectively. The proposed ILFD consumes 3.6 mW from a 0.6 V supply, and the core area is 0.067 mm2.
A standardised method for improving patient education material readability for orthopaedic trauma patients
Authors: Marshall Samuel , Hanish Stefan J. , Baumann John , Groneck Andrew , DeFroda Steven 
Published: February 2024

AbstractPurposeWhile the National Institutes of Health and American Medical Association recommend patient education materials (PEMs) should be written at the sixth‐grade reading level or below, many patient education materials related to traumatic orthopaedic injuries do not meet these recommendations. The purpose of this study is to create a standardised method for enhancing the readability of trauma‐related orthopaedic PEMs by reducing the use of ≥ three syllable words and reducing the use of sentences >15 words in length. We hypothesise that applying this standardized method will significantly improve the objective readability of orthopaedic trauma PEMs.MethodsA patient education website was queried for PEMs relevant to traumatic orthopaedic injuries. Orthopaedic trauma PEMs included (N = 40) were unique, written in a prose format, and <3500 words. PEM statistics, including scores for seven independent readability formulae, were determined for each PEM before and after applying this standard method.ResultsAll PEMs had significantly different readability scores when comparing original and edited PEMs (p < 0.01). The mean Flesch Kincaid Grade Level of the original PEMs (10.0 ± 1.0) was significantly higher than that of edited PEMs (5.8 ± 1.1) (p < 0.01). None of the original PEMs met recommendations of a sixth‐grade reading level compared with 31 (77.5%) of edited PEMs.ConclusionsThis standard method that reduces the use of ≥ three syllable words and <15 word sentences has been shown to significantly reduce the reading‐grade level of PEMs for traumatic orthopaedic injuries. Improving the readability of PEMs may lead to enhanced health literacy and improved health outcomes.
Trastuzumab‐based nanomedicines for breast cancer therapy: Recent advances and future opportunities
Authors: Selepe Cyril T. , Dhlamini Khanyisile S. , Tshweu Lesego , Moralo Maabo , Kwezi Lusisizwe , Ray Suprakas S. , Ramalapa Bathabile 
Published: February 2024

AbstractAccording to the World Health Organization (WHO), there are more than 2.3 million cases of breast cancer (BC) each year, with 80% of deaths occurring in low‐ and middle‐income countries (LMICs). Chemotherapeutic agents are used in the treatment of BC to kill or slow the growth of cancer cells. While they can be effective in many cases, they also have potential side effects. These include long‐term effects such as possible damage to healthy organs, limited efficacy, and resistance development. Trastuzumab (Tmab) offers superior treatment options due to low toxicity and high specificity for a target antigen. However, Tmab treatment, despite being available for the last two decades, has remained challenging and expensive to manage, and inaccessible to people in underserved communities. Therefore, it is necessary to ensure that such effective medication is within reach of those in need, regardless of social or economic class. Recent advances in nanomedicine have led to a growing number of studies that show promise in meeting these challenges through access to adequate anticancer drugs in LMICs. This review analyzes such reports while highlighting the progress of nanomedicine and anticancer drug systems and presents opportunities that have been overlooked over the years for LMICs.
Evidence‐based practice attitudes and nutrition support guideline knowledge between holders and nonholders of the Certified Nutrition Support Clinician credential
Authors: Steiner Lea , Sackey Joachim , Cohen Deborah , Brody Rebecca 
Published: February 2024

AbstractBackgroundClinical practice frequently changes, and professionals should stay abreast of evidence‐based practice (EBP) guidelines. Negative attitudes towards EBP are a barrier to guideline adoption. This study explored EBP attitudes and knowledge of a complex nutrition support clinical case scenario of individuals holding or not holding the Certified Nutrition Support Clinician (CNSC) credential.MethodsThis cross‐sectional study used an online survey sent to American Society for Parenteral and Enteral Nutrition (ASPEN) members with and without the CNSC credential and all CNSC credential holders from the National Board of Nutrition Support Certification email list. The survey included the Evidence‐Based Practice Attitude Scale Score (EBPAS‐15) and eight knowledge questions using a nutrition support case scenario. An independent samples t test compared knowledge and EBPAS‐15 total scores and subscores between CNSC holders and nonholders. Pearson correlation determined the correlation between knowledge and EBPAS‐15 scores.ResultsThe response rate was 7.8% (N = 706). CNSC holders (n = 536) had significantly higher mean knowledge scores (4.7 ± 1.6 out of 8) than nonholders (n = 159, 4.1 ± 1.7) (P < 0.001). Total EBPAS‐15 scores were not significantly different between CNSC holders (n = 542, 2.9 ± 0.4 out of 4) and nonholders (n = 164, 2.8 ± 0.7) (P = 0.434), and knowledge scores and total EBPAS‐15 scores (P = 0.639) or subscores were not significantly correlated.ConclusionsRegardless of holding the CNSC credential, EBPAS‐15 scores indicated respondents had positive EBP attitudes. CNSC holders had significantly higher knowledge scores of recent nutrition support EBP guidelines compared with non–CNSC credential holders. Positive EBP attitudes are a precursor to clinical decision‐making, but future research should determine the use of guidelines in clinical practice.
Cognitive mental workload of emergency nursing: A scoping review
Authors: Surendran Anu , Beccaria Lisa , Rees Sharon , Mcilveen Peter 
Published: February 2024

AbstractAimEmergency nurses work in an environment of high cognitive mental workload. Excessive cognitive mental workload may result in patient harm and nurses' burnout. Therefore, it is necessary to understand nurses' subjective experience of cognitive workload. This scoping review aimed to curate literature about the subjective experience of cognitive mental workload reported by nurses and psychometric measures of the phenomenon.DesignThe scoping review was conducted in accordance with JBI methodology and reported using PRISMA extension for scoping review checklist.MethodsA priori protocol was created with Peer Review of Electronic Search Strategies checklist and registered in the OSF registry. Databases including PubMed, CINAHL, ProQuest, Scopus, Science Direct, Web of Science and Google Scholar were searched. Published reports were reviewed against the eligibility criteria by performing Title and Abstract screening, followed by Full‐text screening. The initial search yielded 1373 studies. Of these, 57 studies met the criteria for inclusion in this study.ResultsThe search revealed five general measures of cognitive mental workload and their variations. Only one customised measure specifically for medical–surgical nurses was found in the study. Identified measures were collated and categorised into a framework for conceptual clarity. NASA Task Load Index and its variations were the most popular subjective measure of cognitive mental workload in nursing. However, no measure or self‐report scale customised for emergency nurses was identified.Patient or Public ContributionThe findings of this scoping review can inform future research into the cognitive mental workload of nurses. The findings have implications for workplace health and safety for nurses and patients.
In praise of postgraduate career clinics: Translating health professionals' willingness to engagement
Authors: Redwood T. , Ward A. , Ali T. , Poole C. , O'Dell C. , Rebaudo D. 
Published: February 2024

AbstractAimTo capture and retain healthcare staff in postgraduate courses relevant to individual career aspirations, service requirements and continuous practice development (CPD) within an English UK university.DesignTwo virtual career clinics for postgraduate practitioners to engage in CPD offers within the university. An online post‐enrolment online survey to explore their experiences of engagement with the university.MethodsMixed: qualitative and quantitative methods. Engaging 10 participants attended the career clinics, and 42 participants with an online survey.ResultsThe career clinics were well received by participants who mapped CPD requirements and individual career aspirations. The surveys exposed challenges with marketing and enrolment; however, these were mitigated with support. Four recommendations are presented within this paper applicable to the international postgraduate education of all health practitioners.
The role of nature's contributions to people in sustaining international trade of agricultural products
Authors: Marques Alexandra , Bonn Aletta , Castro Antonio J. , Chaudhary Abhishek , Felipe‐Lucia María R. , Kastner Thomas , Koellner Thomas , Lancker Kira , Lopez Hoffman Laura , Meyer Carsten , Pfister Stephan , Rabeschini Gabriela , Willemen Louise , Schulp Catharina J. E. 
Published: February 2024

Abstract

Nature's contributions to people (NCP) are essential for the production and trade of agricultural, forestry and fishery commodities. Often, there is a spatial disconnect between consumers and the natural systems where the commodities are produced. Traded agricultural products are therefore dependent on nature and NCP in their region of origin.

The dependencies of agricultural products on NCP are, however, insufficiently recognised by consumers and are rarely considered in global environmental governance and trade policies along value chains.

Here, we synthesise studies highlighting dependencies of agricultural products on NCP in their origin locations to identify opportunities and challenges in quantifying their contribution in sustaining trade flows.

We suggest three methodological steps for quantifying NCP dependencies in international agricultural trade: spatial mapping of NCP supply and demand, linking NCP to agricultural trade flows, and tracing trade flows. Each methodological step requires further development and harmonisation to enable a complete accounting of how international agricultural trade depends on NCP.

Given the lack of knowledge and data on how NCP support agricultural trade, social and environmental trade‐offs of natural resource management are currently hard to quantify. Quantifying the role of NCP dependencies of traded agricultural products can support their sustainable management, contribute to supply chain accountability and serve as input to sustainable natural resource governance and foster responsibility and equity in supply chains.

Read the free Plain Language Summary for this article on the Journal blog.
Effect of stacking order on the properties of hybrid palm sheath/polyester fiber felt‐reinforced polymer composite laminates
Authors: Tang Xin , Liu Qi , Bai Zhongyang , Li Lijuan , Hu Yingcheng 
Published: February 2024

AbstractNatural fiber‐reinforced composites exhibit excellent mechanical properties. However, achieving a balance between excellent mechanical properties and optimal acoustic performance remains a challenge. In this study, four composite laminates with different stacking orders were fabricated using polyester fiber mats (WFs) and palm sheaths (WPs) through a hot‐press process. Moreover, the effects of different stacking orders on the mechanical and acoustic properties of the composite were investigated. The results revealed that the incorporation of polyester fiber felts and the modification of the layup sequence of WP and polyester fiber felts significantly improved the mechanical and acoustic properties of the composites. Scanning electron microscopy images revealed a strong bonding between palm fibers and polyester fibers at the epoxy resin interface. Compared with pure palm fiber composites, the alternately stacked palm fibers and polyester fibers (WP/WP/WF/WP/WF) exhibited the highest mechanical properties, with a significant enhancement of 142.67% and 16.90% in flexural and tensile strengths, respectively. Additionally, the peak absorption coefficient of polyester fiber felts, positioned in the surface layer of the composite material, within the 2580–3400 Hz frequency band significantly increased from 0.07 to 0.44. Therefore, this study indicates that modifying the stacking order improves the mechanical and acoustic properties of the composites, making them suitable for use in acoustic engineering materials for buildings and decorative panels for furniture, including perforated panels and acoustic screens.Highlights
The fabric‐like textured structure significantly enhanced the overall performance of the composites.
The stacking order significantly influenced the overall properties of the composite.
Alternately stacked polyester fiber felts and palm fibers exhibited excellent mechanical performance.
The polyester fiber felts positioned on the surface layer of the composites exhibited superior mechanical performance.
A laminate with “green” attributes and good acoustic properties was fabricated.
Behaviors of arched tunneling segments reinforced by basalt fiber reinforced plastic rebars
Authors: Hou Min , Feng Jiang , Jiang Ruiyi , Shi Hougai , Fan Hualin 
Published: February 2024

AbstractIn this research, basalt fiber reinforced plastic (BFRP) rebars reinforced tunneling segment (BRRTS) technique was developed. All the BFRP rebars were designed, pre‐cured according to the reinforcement design and the reinforcement drawing of steel rebars reinforced concrete tunneling segments (SRRTSs). Two criteria, the equal reinforcement ratio criterion (ERRC) and the half stiffness principle (HSP), were applied to design the BRRTs. Bending experiments were performed to reveal the deformation, damage and load carrying capacity of the BRRTSs. With flexural‐shearing coupling failure mode, the BRRTS has longer elastoplastic deformation and comparable (ERRC) or much greater (HSP) load carrying capacity compared with traditional SRRTS, indicating that the BRRTS can replace the SRRTS in some cases.Highlights
BFRP rebars reinforced tunneling segment was designed, constructed, and tested.
BFRP rebars reinforced tunneling segment has long ductile deformation.
BFRP rebars reinforced tunneling segment has higher load‐bearing capacity.
Utilization efficiency of BFRP rebars varies from 0.565 to 0.646.
Mechanically enhanced battery separator prepared by hot‐pressing electrospun polyvinylidene fluoride@polymethyl methacrylate membranes with different fiber orientations in adjacent layers
Authors: Ye Ang , De Guzman Manuel Reyes , Ye Jiankang , Xu Changkangle , Zhou Feiyu , Chen Xuedan , Zhu Wenli , Gong Die , Fu Qingshan 
Published: February 2024

AbstractCompared with commercial polyolefin membranes, electrospun polymeric membranes have the advantages of higher porosity and better electrolyte wettability, but their poor mechanical performance limits their industrial use as battery separators. In this work, a layer‐to‐layer electrospinning is used for fabrication of PVdF@PMMA membranes, in which fibers in adjacent layers are arranged at a certain angle (0°, 30°, 60°, 90°). The as‐electrospun membranes are further hot‐pressed to boost their mechanical strength. Various techniques are employed to evaluate the membranes, such as scanning electron microscopy, differential scanning calorimetry, contact angle measurement, electrochemical impedance spectroscopy, and linear sweep voltammetry. The results show that polymethyl methacrylate partially melts during the hot‐pressing treatment, causing adjacent fibers in the membranes to bridge. The obtained membranes show different tensile strength values with the various angles between fibers. When the angle is 30°, the tensile strength can reach 22.09 MPa and higher porosity (74.68%), greater liquid electrolyte absorption (612.36%) than that of commercial polyolefin membrane are harvested. The lithium‐ion cell assembly with the membrane separator exhibits a discharge capacity reaching 142 mAh g−1 and an excellent capacity retention of 90.7%. This present study provides an innovative and promising approach for the fabrication of high‐performance battery separator by electrospinning.Highlights
PVdF@PMMA membranes are prepared by a layer‐to‐layer electrospinning.
In the membranes, fiber orientation in adjacent layers is kept at a certain angle.
Hot‐pressing further boosts mechanical performance of the membranes.
Membranes with different angle of fibers show various mechanical strengths.
Wearable electronic devices in parasports: A focused review on para athlete classification
Authors: Nikolis Louis , Graff Crystal , Nikolis Andrea , Tow Stephanie 
Published: February 2024

AbstractWearable electronic devices are being used to evaluate movement patterns, track workload, prevent injuries, and optimize performance in athletes. Para athletes have unique characteristics to consider separately from the general population. One such difference in competitive parasports includes consideration of athlete classification systems. These sport‐specific classification systems consider athletes' eligible medical conditions that lead to permanent physical, visual, and/or intellectual impairments and objectively evaluate the impact of their impairments on sport functions. Para athletes are assigned sport classes and compete with athletes of similar functional levels. This promotes equitable opportunities to compete while minimizing the effect their impairment has on their sport performance. With recent reports of misrepresentation or incorrect and unfair classification providing unfair advantages to some athletes, parasports classification has been controversial. Having an objective, evidence‐based, and fair classification system in parasports is critical to maintain the integrity of parasports competition. Wearable electronic devices have potential to provide more objective analysis of movement patterns in para athletes to assist in sport classification. This review identifies and analyzes the available literature on wearable electronic technology and its role in parasports classification. A comprehensive PubMed and Google Scholar search identified six articles included in this review. These studies used inertial sensors, motion capture systems, or surface electromyography in wheelchair basketball, rugby, tennis, sit skiing, and boccia. This review identifies the potential value of wearable electronic devices to assist in parasports classification. Additional studies are needed to create standardized protocols for each sport and sensor type.
Improved corrosion resistance and cytotoxicity of nickel‐based alloy using novel plasma processing technique
Authors: Yousaf Muhammad , Iqbal Tahir , Mansha Muhammad Salim , Saeed Adnan , Abrar Muhammad , Afsheen Sumera , Ahmed Irfan , AlObaid Abeer A. , Al‐Maswari Basheer M. , Yasir Muhammad 
Published: February 2024

AbstractIn this study, we address challenges in the biocompatibility of nickel‐based (NiCr) alloys, prevalent in the dental industry, due to toxic metal ion release impacting corrosion resistance and cytotoxicity. Employing magnetron sputtering and cathodic cage plasma nitriding (CCPN), a duplex plasma treatment (DPT) is introduced to the NiCr alloy. The novel approach enhances surface morphology, notably reducing ion leakage compared with untreated samples. Specifically, the CCPN‐TiN‐treated sample significantly improves corrosion resistance and minimizes metal ion leakage. This transformative DPT emerges as a promising solution for surface modification, particularly mitigating toxic ion leaching in aggressive electrolytes. This research demonstrates a major stride in enhancing NiCr alloy biocompatibility, emphasizing the vital role of innovative surface modification techniques for biomedical applications and challenges.
Safety attitudes among workers in Malaysian chemical manufacturing plants
Authors: Zakaria Junaidah , Hassan Che Rosmani Che , Hamid Mahar Diana , Sukadarin Ezrin Hani 
Published: February 2024

AbstractStatistics in Malaysia show that accident cases in the manufacturing industry are the highest compared with other sectors. Concerns regarding changing workers' attitudes, controlling their current perceptions, and installing knowledge and experiences that travel through the culture are necessary. This study investigates workers' attitudes to safety between executives and operators. A total number of 309 respondents voluntarily participated. Results report that respondents' attitude toward individual responsibility (M = 4.24, SD = 0.63) is the highest, followed by the effectiveness of safety arrangements (M = 3.91, SD = 0.81) and safeness of the work environment (M = 3.17, SD = 0.73). Results revealed a significant difference between groups (t = 6.67, p = 0.014) for personal skepticism and (t = 15.775, p = 0.001) for personal immunity. There was a statistically positive correlation between attitudes measured with selected demographic factors. It can be concluded that increases in the level of education were associated with increases in individual responsibility, and an increase in age was directly correlated with increases in the effectiveness of safety arrangements. Furthermore, different groups of workers influence their attitudes toward safety arrangements and safeness of the work environment. This study can be used as a preliminary study or the first step for enhancing an organizational safety culture through behavior and attitude change.