bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive models for health outcomes due to SARS-CoV-2, including the effect of vaccination: a systematic review
Authors: Espinosa Oscar , Mora Laura , Sanabria Cristian , Ramos Antonio , Rincón Duván , Bejarano Valeria , Rodríguez Jhonathan , Barrera Nicolás , Álvarez-Moreno Carlos , Cortés Jorge , Saavedra Carlos , Robayo Adriana , Franco Oscar H. 
Published: January 2024

Abstract
Background
The interaction between modelers and policymakers is becoming more common due to the increase in computing speed seen in recent decades. The recent pandemic caused by the SARS-CoV-2 virus was no exception. Thus, this study aims to identify and assess epidemiological mathematical models of SARS-CoV-2 applied to real-world data, including immunization for coronavirus 2019 (COVID-19).

Methodology
PubMed, JSTOR, medRxiv, LILACS, EconLit, and other databases were searched for studies employing epidemiological mathematical models of SARS-CoV-2 applied to real-world data. We summarized the information qualitatively, and each article included was assessed for bias risk using the Joanna Briggs Institute (JBI) and PROBAST checklist tool. The PROSPERO registration number is CRD42022344542.

Findings
In total, 5646 articles were retrieved, of which 411 were included. Most of the information was published in 2021. The countries with the highest number of studies were the United States, Canada, China, and the United Kingdom; no studies were found in low-income countries. The SEIR model (susceptible, exposed, infectious, and recovered) was the most frequently used approach, followed by agent-based modeling. Moreover, the most commonly used software were R, Matlab, and Python, with the most recurring health outcomes being death and recovery. According to the JBI assessment, 61.4% of articles were considered to have a low risk of bias.

Interpretation
The utilization of mathematical models increased following the onset of the SARS-CoV-2 pandemic. Stakeholders have begun to incorporate these analytical tools more extensively into public policy, enabling the construction of various scenarios for public health. This contribution adds value to informed decision-making. Therefore, understanding their advancements, strengths, and limitations is essential.
Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis
Authors: Silva Sarah , Fatumo Segun , Nitsch Dorothea 
Published: January 2024

Abstract
Background
Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide. We aimed to summarize what is currently known with regard to causal modifiable risk factors associated with CAD in populations of diverse ancestries through conducting a systematic review and meta-analysis of Mendelian randomization (MR) studies on CAD.

Methods
The databases Embase, Medline, Cochrane Library and Web of Science were searched on the 19th and 20th of December 2022 for MR studies with CAD as a primary outcome; keywords of the search strategy included “coronary artery disease” and “mendelian randomization”. Studies were included if they were published in the English language, included only human participants, employed Mendelian randomization as the primary methodology and studied CAD as the outcome of interest. The exclusion criteria resulted in the removal of studies that did not align with the predefined inclusion criteria, as well as studies which were systematic reviews themselves, and used the same exposure and outcome source as another study.
An ancestry-specific meta-analysis was subsequently conducted on studies which investigated either body mass index, lipid traits, blood pressure or type 2 diabetes as an exposure variable. Assessment of publication bias and sensitivity analyses was conducted for risk of bias assessment in the included studies.

Results
A total of 1781 studies were identified through the database searches after de-duplication was performed, with 47 studies included in the quantitative synthesis after eligibility screening. Approximately 80% of all included study participants for MR studies on CAD were of European descent irrespective of the exposure of interest, while no study included individuals of African ancestry. We found no evidence of differences in terms of direction of causation between ancestry groups; however, the strength of the respective relationships between each exposure and CAD were different, with this finding most evident when blood pressure was the exposure of interest.

Conclusions
Findings from this review suggest that patterns regarding the causational relationship between modifiable risk factors and CAD do not differ in terms of direction when compared across diverse ancestry populations. Differences in the observed strengths of the respective relationships however are indicative of the value of increasing representation in non-European populations, as novel genetic pathways or functional SNPs relating to CAD may be uncovered through a more global analysis.

Systematic review registration
The protocol for this systematic review was registered to the International Prospective Register of Systematic Reviews (PROSPERO) and is publicly available online (CRD42021272726).
Factors affecting nursing practice of patient physical restraint among nurses
Authors: Kim Jihyun , Yang Yaki 
Published: January 2024

Abstract
Background
This study was aimed to identify perception, knowledge, attitude and nursing practice toward use of physical restraints among clinical nurses.

Methods
The research participants were 180 nurses from general hospitals located in Korea. Data were collected using self-report questionnaires regarding perception, attitude, knowledge, and nursing practice on application of physical restraints and analyzed using t-test, ANOVA, Pearson correlation coefficients, and multiple regression.

Results
There were significant negative relationships attitudes towards the use of physical restraints with knowledge (r = -.32, p < .001). Knowledge showed a positive correlation with nursing practice (r = .28, p < .001). Factors affecting nursing practice of clinical nurses were identified as knowledge (β = .23), education experiences on physical restraints (Yes) (β = .18), and work unit (ICU) (β = .43). The explanation power of this regression model was 22% and it was statistically significant (F = 7.45, p < .001).

Conclusion
This study suggests that knowledge, education experiences on physical restraints, and work unit were the strongest predictor on nursing practice toward use of patient physical restraints. Therefore, developing and applying evidence-based educational intervention programs by work unit to reduce the inappropriate use of physical restraints in hospitals are required.
How to support innovative small firms? Bibliometric analysis and visualization of start-up incubation
Authors: Máté Domicián , Estiyanti Ni Made , Novotny Adam 
Published: January 2024

AbstractSupporting the birth and development of innovative small firms, i.e., start-up incubation, has emerged as a critical factor in fostering entrepreneurship, innovation, regional development, and more recently, sustainability. This bibliometric review aims to comprehensively understand and visualize different research perspectives on how start-ups are successfully incubated. A total of 1116 Scopus articles were selected and synthesized using a qualitative approach. The study applies novel visualization techniques (Citation Network Analysis, Global Citation Score, Burst Detection Analysis and Co-Occurrence Networks of Keywords) to map the scientific structure of start-up incubation research, including the clusters of the leading research topics based on citation networks, the most cited articles, and the keywords with the most substantial citation bursts as well as their co-occurrence. We evaluate research on start-up incubation from 1972 to 2023 and show how the topic has advanced by scholars’ changing interests over time. We identify five clusters that reflect distinct study themes and their most cited references. The findings contribute to a more comprehensive understanding of the evolution of start-up incubation research, which developed from a focus on biotechnology and technology transfer toward the current research trends on accelerators and (entrepreneurial) ecosystems. This paper also provides insights for policymakers and start-up incubation managers to make informed decisions.
The influence of gender on the epidemiology of and outcome from sepsis associated acute kidney injury in ICU: a retrospective propensity-matched cohort study
Authors: Jiang Wei , Song Lin , Zhang Yaosheng , Ba Jingjing , Yuan Jing , Li Xianghui , Liao Ting , Zhang Chuanqing , Shao Jun , Yu Jiangquan , Zheng Ruiqiang 
Published: January 2024

Abstract
Purposes
The influence of gender on the epidemiology of and outcome from SA-AKI in ICU has not been fully clarified. Our aim is to elucidate these differences.

Methods
This study included adult patients with sepsis in MIMIC IV (V 2.2), and propensity matching analysis, cox regression and logistic regression were used to analyze gender differences in incidence, mortality and organ support rate.

Results
Of the 24,467 patients included in the cohort, 18,128 were retained after propensity score matching. In the matched cohort, the incidence of SA-AKI in males is higher than that in females (58.6% vs. 56.2%; P = 0.001).males were associated with a higher risk of SA-AKI (OR:1.07(1.01–1.14), P = 0.026;adjusted OR:1.07(1.01–1.14), P < 0.033).In SA-AKI patients, males were associated with a lower risk of ICU mortality(HR:0.803(0.721–0.893), P < 0.001;adjusted HR:0.836(0.746–0.937), P = 0.002) and in-hospital mortality(HR: 0.820(0.748–0.899), P < 0.001;adjusted HR:0.853(0.775–0.938), P = 0.003).there were no statistically significant differences between male and female patients in 1-year all-cause mortality (36.9% vs. 35.8%, P = 0.12), kidney replacement therapy rate (7.8% vs.7.4%, P = 0.547), mechanical ventilation rate 64.8% vs.63.9%, P = 0.369), and usage of vasoactive drugs (55.4% vs. 54.6%, P = 0.418).

Conclusions
Gender may affect the incidence and outcomes of SA-AKI, further research is needed to fully understand the impact of gender on SA-AKI patients.
Biomarkers for neurodegeneration impact cognitive function: a longitudinal 1-year case–control study of patients with bipolar disorder and healthy control individuals
Authors: Knorr Ulla , Simonsen Anja Hviid , Zetterberg Henrik , Blennow Kaj , Willkan Mira , Forman Julie , Miskowiak Kamilla , Hasselbalch Steen Gregers , Kessing Lars Vedel 
Published: January 2024

Abstract
Background
Abnormalities in cerebrospinal fluid (CSF)-amyloid-beta (Aβ)42, CSF-Aβ40, CSF-Aβ38, CSF-soluble amyloid precursor proteins α and β, CSF-total-tau, CSF-phosphorylated-tau, CSF-neurofilament light protein (NF-L), CSF-neurogranin, plasma-Aβ42, plasma-Aβ40, plasma-total-tau, plasma-NF-L and, serum-S100B during affective episodes may reflect brain changes that could impact cognitive function in patients with bipolar disorder (BD). The study aimed to investigate the association between these biomarkers indicative of Alzheimer’s disease and those reflecting neurodegeneration alongside their impact on cognitive function in patients with BD and healthy control individuals (HC). The primary hypothesis was that GL and VL would increase with increasing levels of CSF-Aβ42 based on data from T0 and T3 in BD and HC jointly.

Methods
In a prospective, longitudinal case–control study euthymic patients with BD (N = 85) and HC (N = 44) were evaluated with clinical assessment and neuropsychological testing at baseline (T0) and during euthymia after a year (T3). Patients’ affective states were recorded weekly as euthymic, subthreshold level, major depression, or (hypo)mania. If an episode occurred during follow-up, the patient was also assessed in post-episode euthymia. Cognitive performance was measured as a global cognitive score (GL) for four cognitive domains including verbal learning and memory (VL).

Results
Estimated in a linear mixed model GL increased with 0.001 for each increase of 1 pg/ml of CSF-Aβ42 (97.5%, CI 0.00043–0.0018, adjusted-p = 0.0005) while VL increased by 0.00089 (97.5%, CI 0.00015–0.0018, adjusted-p = 0.045) in BD and HC jointly. The association was weak, however stronger in patients with BD compared to HC. Associations between other biomarkers including CSF-neurogranin, and cognitive domains were overall weak, and none remained significant after adjustment for multiple testing.

Limitations
Modest sample size. A complete data set regarding both CSF-AB-42 and cognitive test scores was obtained from merely 61 patients with BD and 38 HC individuals.

Conclusion
CSF-Aβ42 may be associated with cognitive dysfunction in patients with BD and HC individuals. The association appeared to be stronger in BD but with overlapping confidence intervals. Hence it remains uncertain whether the association is a general phenomenon or driven by BD.
Empirical evaluation of the strength and deformation characteristics of natural and synthetic gas hydrate-bearing sediments with different ranges of porosity, hydrate saturation, effective stress, and strain rate
Authors: Yoneda Jun , Suzuki Kiyofumi , Oshima Motoi , Muraoka Michihiro , Jin Yusuke 
Published: January 2024

AbstractEvaluating the mechanical properties of gas (primarily methane) hydrate-bearing sediments is essential for commercial production as a next-generation resource and understanding the global carbon cycle. Triaxial and uniaxial compression tests have been conducted on synthetic gas hydrate and natural core samples recovered from deep-sea beds using pressure coring techniques. The results show that four factors are vital in establishing the strength of hydrate-bearing sediments: hydrate saturation, effective confining stress, porosity, and strain rate. However, no study has evaluated these factors in a unified and quantitative manner, and even if the physical properties of the reservoir are known in detail from logging, predicting the strength has been challenging. In this study, pressure cores were drilled and recovered from the Eastern Nankai Trough in April 2018 after Japan’s second offshore production test, and triaxial or uniaxial compression tests were performed on 12 pressure core samples brought back to the laboratory. The mechanical properties of the hydrate-bearing sediments were classified with previous obtained results from 53 pressure cores and 223 synthetic cores, and empirical equations for triaxial compressive strength and deformation modulus were proposed as functions of gas hydrate saturation, effective confining pressure, porosity, and strain rate. The obtained equations were found to correlate well with the experimental data and can predict the strength and deformation modulus from logging data.
A case of pancreaticoduodenal artery bleeding after laparoscopic right colectomy requiring open hemostasis
Authors: Ono Rika , Tominaga Tetsuro , Nonaka Takashi , Takamura Yuma , Oishi Kaido , Shiraishi Toshio , Hashimoto Shintaro , Noda Keisuke , Sawai Terumitsu , Nagayasu Takeshi 
Published: January 2024

AbstractBackgroundPancreatic and duodenal-related complications after right colectomy carry a higher risk of mortality.Case presentationA 64-year-old woman underwent laparoscopic right colectomy for a laterally spreading tumor in the cecum. On postoperative day 10, she experienced sudden hematemesis. Contrast-enhanced computed tomography (CT) of the abdomen showed a large amount of hemorrhage in the stomach, but no obvious extravasation. In addition, free air was observed near the duodenal bulb. Despite blood transfusion, vital signs remained unstable and emergency surgery was performed. The abdomen was opened through midline incisions in the upper and lower abdomen. A fragile wall and perforation were observed at the border of the left side of the duodenal bulb and pancreas, with active bleeding observed from inside. As visualization of the bleeding point proved difficult, the duodenum was divided circumferentially to confirm the bleeding point and hemostasis was performed using 4-0 PDS. The left posterior wall of the duodenum was missing, exposing the pancreatic head. For reconstruction, the jejunum was elevated via the posterior colonic route and the duodenal segment and elevated jejunum were anastomosed in an end-to-side manner. Subsequently, gastrojejunal and Brown anastomoses were added. Drains were placed before and after the duodenojejunal anastomosis. Postoperative vital signs were stable and the patient was extubated on postoperative day 1. Follow-up contrast-enhanced CT of the abdomen showed no active bleeding, and the patient was discharged home on postoperative day 21. As of 6 months postoperatively, the course of recovery has been uneventful.ConclusionsWe encountered a case of pancreaticoduodenal artery hemorrhage after laparoscopic right colectomy. Bleeding at this site can prove fatal, so treatment plans should be formulated according to the urgency of the situation.
Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis
Authors: Farahbakhsh Nazanin , Fatahi Somaye , Shirvani Armin , Motaharifard Monireh Sadat , Mohkam Masoumeh , Tabatabaii Seyed Ahmad , khanbabaee Ghamartaj , Yaghoobpoor Shirin , Davoodi Seyedeh Zahra , Hosseini Amir hossein 
Published: January 2024

Abstract
Aim
Vitamin D is a prominent modulator of immunity and respiratory function. It plays a vital role in respiratory diseases such as cystic fibrosis (CF). S. However, there is a dearth of information on patients with CF. The purpose of the meta-analysis is to highlight the importance of following the existing guidelines regarding maintenance of Vitamin D serum levels in patients with CF.

Methods
The systematic search was conducted without utilizing any time or language limitations in original database from the beginning until March 2022. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I2 statistics and Cochrane Q test.

Results
Pooled analysis using the random-effects model of the 8 case–control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescences (WMD: − 3.41 ng/ml, 95% CI − 5.02, − 1.80, p =  < 0.001) and adults (WMD: − 2.60 ng/ml, 95% CI − 4.32, − 0.89, p = 0.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20–30 ng/ml in CF patients was 36% among pediatrics/adolescents and 63% among adults. In addition, 27% of pediatric/adolescent CF patients and 35% of adult CF patients had vitamin D levels of below 20 ng/ml.

Conclusions
As a result, according to the existing guidelines, our results proved the need to pay attention to the level of vitamin D in these patients.
Association between diet quality and risk of stunting among school-aged children in Schistosoma mansoni endemic area of western Kenya: a cross-sectional study
Authors: Kishino Madoka , Hida Azumi , Chadeka Evans A. , Inoue Manabu , Osada-Oka Mayuko , Matsumoto Sohkichi , Njenga Sammy M. , Hamano Shinjiro , Nagi Sachiyo 
Published: January 2024

Abstract
Background
Healthy eating habits are essential for improving nutritional status and strengthening immunity against infectious diseases. This study examined the relationship between diet quality and stunting in school-aged children in an infectious disease-endemic area of western Kenya.

Methods
This cross-sectional study included 260 school-aged children (age 9–17 years) enrolled in primary schools in Mbita Sub-county, western Kenya. The nutritional status was assessed using anthropometric measurements. Dietary intake was measured using food frequency questionnaires and evaluated using the Food Pyramid (FP) score, which indicates adherence to the Kenyan food-based dietary guideline. Information on the children’s age, sex, maternal education, and household wealth index was collected using a household-based questionnaire. Infections with the predominant parasites, such as Schistosoma (S.) mansoni, were detected via microscopy. The trend associations of the FP score with food group intake were examined to characterize the dietary intake of this population. Logistic regression analysis was performed to investigate the relationship between stunting and FP score tertiles, adjusted for sociodemographic and economic indicators and parasitic infection status.

Results
Among the studied schoolchildren, 15.0% exhibited stunting, while 76.2% were infected with S. mansoni. The mean FP score was 25.6 out of 50 points. A higher FP score was characterized by a high intake of roots and tubers, dairy products, pulses, and fruits and a low intake of cereals and animal-source foods. The analysis revealed a trend: a lower risk of stunting was evident in groups with elevated FP scores (p for trend = 0.065). However, these trend associations were observable among subjects with either negative or light S. mansoni infection (p for trend = 0.016).

Conclusions
A higher quality diet, as evaluated by FP scores, was associated with a low risk of stunting among school-aged children. Notably, this association seemed to weaken in the presence of a high burden of S. mansoni infection. It highlights the importance of enhancing dietary quality through the promotion of diverse nutrient-dense foods alongside effective S. mansoni infection control for improved growth. This study contributes fundamental knowledge for understanding the diet–malnutrition relationship in areas endemic for S. mansoni infection.