bluuebunny/crossref_metadata_2025_split huggingface dataset:
KONO-S Anastomosis Is Not Superior to Conventional Anastomosis for the Reduction of Postoperative Endoscopic Recurrence in Crohn’s Disease
Authors: Tyrode Gaëlle , Lakkis Zaher , Vernerey Dewi , Falcoz Antoine , Clairet Valentine , Alibert Line , Koch Stéphane , Vuitton Lucine 
Published: September 2023

Abstract

Background
Surgical resection rates remain high in Crohn’s disease (CD). Reducing postoperative recurrence (POR) is challenging. Besides drug therapy, the surgical anastomosis technique may reduce POR. We aimed to compare the endoscopic POR rate after Kono-S vs standard ileocolic anastomosis.

Methods
The study included all consecutive CD patients operated on for ileocolic resection with a Kono-S anastomosis between February 2020 and March 2022. These patients were prospectively followed, and colonoscopy was performed 6 to 12 months after surgery. Patients were compared with a historical cohort of patients operated on with a conventional anastomosis in the same center. The primary end point was endoscopic POR (Rutgeerts score ≥i2). Factors associated with POR were assessed by univariate and multivariable analyses.

Results
A total of 85 patients were included, 30 in the Kono-S group and 55 in the control group. At baseline, there was no significant difference between the 2 groups regarding CD characteristics or known POR risk factors, including previous exposure to biologics. At 6 to 12 months, endoscopic POR rate did not differ significantly between groups (56.7% in the Kono-S group vs 49.1% in the control group; P = .50), nor did endoscopic POR according to the modified Rutgeerts score ≥i2b (46.7% in the Kono-S group vs 40% in the control group; P = .55). Severe endoscopic POR rates were 23.3% and 18.2% in each group, respectively. Clinical recurrence rate was similar in both groups, and no recurrent surgery occurred. By multivariable analysis, the type of anastomosis was not associated with endoscopic POR (OR, 1.229; 95% CI, 0.461-3.274, P = .68); however, postoperative treatment with anti-TNF was (OR, 0.337; 95% CI, 0.131-0.865 P = .02).

Conclusions
Kono-S anastomosis was not associated with a reduced rate of endoscopic POR. These results warrant confirmation in prospective, randomized, multicenter studies.
An analysis of the early impacts of COVID-19 on Peruvian fisheries and mariculture
Authors: Kluger L C , Garteizgogeascoa M , Gonzales I E , Odar L A , Flitner M , Damonte G 
Published: September 2023

Abstract
The coastal waters off Peru are among the world’s most productive, thanks to the Humboldt Current and its strong coastal upwelling. Fisheries and an ever-expanding mariculture sector provide millions of Peruvians livelihoods, income, and nutrition. Coastal communities engaging with these sectors face a volatile environment they have historically adapted to. But when the COVID-19 pandemic unfolded in 2020, affecting all aspects of life, challenges for the fisheries and mariculture sectors emerged to a yet unprecedented extent. This work applies a mixed-method approach for documenting and analysing the effects of the pandemic on the Peruvian seafood sector and seafood worker’s economy in particular. Mobility restrictions and market closures disrupted seafood supply chains, altering access to nutrition and income for many people involved. Interviewees aimed to diversify livelihood strategies and use personal networks to withstand the crisis, while some established adaptation strategies, such as migration towards other fishing grounds, were largely impeded. Our results highlight the vulnerability of seafood value chains—mainly artisanal and small-scale fisheries—in the face of such a global crisis. The implications of the pandemic for the long-term sustainability of Peruvian coastal–marine activities are discussed and set into the context of previously experienced crises in the region.
Toward a Truly Universal Declaration of Human Rights: Talking Cultural Transformation with Abdullahi Ahmed An-Naim
Authors: Phillips Brian 
Published: September 2023

Abstract
This review considers Abdullahi Ahmed An-Naim’s Decolonizing Human Rights and explores the book’s key implications for human rights practitioners and their organizations. The review also includes An-Naim’s reflections on the book as shared in an interview with Brian Phillips, Journal of Human Rights Practice Reviews Editor, in November 2022. The piece inaugurates a series of essays which will appear in the journal’s Review Section in the year ahead marking the 75th Anniversary of the Universal Declaration of Human Rights.
The effect of leptin on trained innate immunity and on systemic inflammation in subjects with obesity
Authors: Flores Gomez Daniela , Bekkering Siroon , ter Horst Rob , Cossins Benjamin , van den Munckhof Inge C L , Rutten Joost H W , Joosten Leo A B , Netea Mihai G , Riksen Niels P 
Published: September 2023

AbstractLeptin is associated with cardiometabolic complications of obesity, such as metabolic syndrome and atherosclerosis. In obese men, the presence of metabolic syndrome is associated with higher circulating leptin and interleukin (IL)-6 concentrations and increased monocyte cytokine production capacity. Here, we investigated the effects of leptin on monocyte function and systemic inflammatory markers in obese individuals. We specifically explored whether leptin can induce long-term changes in innate immune function by inducing innate immune memory (also called trained immunity). We exposed human primary monocytes for 24 h to relevant leptin concentrations in vitro and measured cytokine production. In addition, after removing leptin, we incubated monocytes for 5 d in culture medium, and we restimulated them on day 6 to assess cytokine production capacity, phagocytosis, and foam cell formation. Direct stimulation with leptin did not induce cytokine production, but exposure to 50 ng/mL leptin augmented lipopolysaccharide- and R848-induced tumor necrosis factor α (TNF-α) production after 1 wk. In a separate in vivo study in a cohort of 302 obese subjects (body mass index [BMI] &gt;27 kg/m2, 55 to 81 yr), we measured circulating leptin, inflammatory markers, and cytokine production upon ex vivo stimulation of isolated peripheral blood mononuclear cells. Circulating leptin concentrations positively correlated with circulating IL-1β and IL-6, which was more pronounced in men than in women. Four single nucleotide polymorphisms in the leptin gene influenced circulating IL-6 concentrations in men, suggesting a direct effect of leptin on IL-6. In conclusion, in vitro, leptin does not directly stimulate monocytes to produce cytokines, yet induces long-term monocyte hyperresponsiveness, i.e. trained immunity. In obese subjects, leptin is associated with circulating IL-6 in a sex-dependent manner. The underlying mechanisms of the sex-specific effect of leptin on innate immune cells remain to be further investigated.
The Relational Care Framework: Promoting Continuity or Maintenance of Selfhood in Person-Centered Care
Authors: Tieu Matthew , Matthews Steve 
Published: September 2023

Abstract
We argue that contemporary conceptualizations of “persons” have failed to achieve the moral goals of “person-centred care” (PCC, a model of dementia care developed by Tom Kitwood) and that they are detrimental to those receiving care, their families, and practitioners of care. We draw a distinction between personhood and selfhood, pointing out that continuity or maintenance of the latter is what is really at stake in dementia care. We then demonstrate how our conceptualization, which is one that privileges the lived experiences of people with dementia, and understands selfhood as formed relationally in connection with carers and the care environment, best captures Kitwood’s original idea. This conceptualization is also flexible enough to be applicable to the practice of caring for people at different stages of their dementia. Application of this conceptualization into PCC will best promote the well-being of people with dementia, while also encouraging respect and dignity in the care environment.
Conditional Assistance: Entrapment Concerns and Individual-Level Support for US Alliance Partners
Authors: Justwan Florian , Berejikian Jeffrey D 
Published: September 2023

Abstract
In this paper, we explore how concerns about entrapment influence mass attitudes about armed support for an alliance partner. We focus on two separate dimensions of entrapment: allied crisis instigation and the risk of direct entanglement in a nuclear conflict. Our empirical analysis is based on US experimental survey data, collected in 2021. Our data analysis reveals two main findings. First, people are less likely to endorse military action in support of another country if that state is perceived as the instigator of a given military crisis. However, we find that allied crisis instigation only reduces individual-level support for certain types of military operations (cruise missile and nuclear strikes) but not others. Furthermore, even where significant, the substantive effect of our experimental vignette is fairly limited. This implies that US voters are not particularly sensitive to the potential for offensive entrapment in the US–South Korean alliance. Second, we find that nuclear deterrence threats from international rivals sap public support for military action. However, this is only true (1) for conventional military attacks and (2) if the US President does not provide a substantive justification for military intervention. As soon as leaders offer a detailed rationale for military action, the negative effect of foreign nuclear threats on support for the use of force disappears.
Referral to Adolescent Weight Management Interventions: Qualitative Perspectives From Providers
Authors: Darling Katherine E , Warnick Jennifer , Guthrie Kate M , Santos Melissa , Jelalian Elissa 
Published: September 2023

Abstract

Objective
Current guidelines for treatment of obesity in adolescence include screening and referring youth with obesity to appropriate weight management (WM) care. However, prior work has not explored the referral process to adolescent WM programs, especially for youth from lower-income backgrounds, who are at increased risk of obesity and related negative health outcomes. This qualitative study sought to understand pediatricians’ current practices regarding referrals to adolescent WM interventions with a focus on adolescents from lower-income backgrounds.

Methods
Individual interviews were conducted with 11 medical providers that had referred at least 5 adolescents from low-income backgrounds to WM interventions. Applied thematic analysis was used for data analysis.

Results
Identified themes included weight-related discussions with adolescents as potentially fraught, as providers want to address weight-related health concerns while being thoughtful about potential harm. Providers also noted varied factors affecting their decision to refer to WM programs, including health implications, perceived motivation of the patient and family, and availability of programs. Providers identified that many families experience shame or guilt around referral to WM. Few themes were identified regarding impact of income on weight-related conversations with adolescents.

Conclusion
Findings were novel in regard to discussions of weight in adolescents with obesity leading to WM referral. Despite being a primary focus of the present study, few themes were identified regarding specific considerations for adolescents from low-income backgrounds. Future clinical research should focus on provider-focused interventions to increase sensitivity regarding weight-related discussions and attention to diversity, equity, and inclusion.
General Regulatory Factor7 regulates innate immune signalling to enhance Verticillium wilt resistance in cotton
Authors: Liu Fujie , Cai Sheng , Wu Peng , Dai Lingjun , Li Xinyi , Ai Nijiang , Feng Guoli , Wang Ningshan , Zhou Baoliang 
Published: September 2023

Abstract
Sessile growing plants are always vulnerable to microbial pathogen attacks throughout their lives. To fend off pathogen invasion, plants have evolved a sophisticated innate immune system that consists of cell surface receptors and intracellular receptors. Somatic embryogenesis receptor kinases (SERKs) belong to a small group of leucine-rich repeat receptor-like kinases (LRR-RLKs) that function as co-receptors regulating diverse physiological processes. GENRAL REGULATORY FACTOR (GRF) proteins play an important role in physiological signalling transduction. However, the function of GRF proteins in plant innate immune signalling remains elusive. Here, we identified a GRF gene, GauGRF7, that is expressed both constitutively and in response to fungal pathogen infection. Intriguingly, silencing of GRF7 compromised plant innate immunity, resulting in susceptibility to Verticillium dahliae infection. Both transgenic GauGRF7 cotton and transgenic GauGRF7 Arabidopsis lines enhanced the innate immune response to V. dahliae infection, leading to high expression of two helper NLRs (hNLR) genes (ADR1 and NRG1) and pathogenesis-related genes, and increased ROS production and salicylic acid level. Moreover, GauGRF7 interacted with GhSERK1, which positively regulated GRF7-mediated innate immune response in cotton and Arabidopsis. Our findings revealed the molecular mechanism of the GRF protein in plant immune signaling and offer potential opportunities for improving plant resistance to V. dahliae infection.
ACNPs in the U.S. Army—Medical Force Multipliers for Large-Scale Combat Operations
Authors: Grabowski Robert L , Stene Edward C , Armen Scott B , Boyer Matthew C 
Published: September 2023

ABSTRACT
Operations in the Middle East have slowed, and near-peer tensions escalate. The U.S. Military has directed its attention from combating insurgencies toward preparedness for large-scale combat operations (LSCOs). The threat of LSCO demands a dramatic shift in strategy and resource and has raised questions about how the military will pivot from the counter-insurgency operations of the previous two decades. Innovation and change are needed to adequately receive, treat, hold, and transport the high volume of anticipated casualties in LSCO. Review of the current deployed medical structure has identified needs to increase emergency medical capabilities near the point of injury, increase patient holding capacity (particularly in critical care) in field hospitals and expeditionary medical facilities, and address likely delayed and prolonged medical evacuation. To address these new challenges, the authors offer recommendations for the addition of Acute Care Nurse Practitioners (ACNPs) to the U.S. Army Medical Department. ACNPs are advanced practice providers, specialized in acute and critical care. ACNPs are a potential medical force multiplier not currently utilized in the U.S. Army. If adapted, ACNPs could contribute significantly to meeting the demands of LSCO medical needs via multiple roles. Recommendations are provided by the authors, such as utilizing the ACNP within the Forward Resuscitative Surgical Detachment, Field Hospital intensive care unit, aeromedical evacuation, and/or Prolonged Care Augmentation Detachment. With support from the U.S. Army Nurse Corp and Army Medical Department, ACNPs could be integrated into the Army healthcare model, emulating the civilian standard of care for every soldier deployed. Furthermore, use of ACNPs in theater could advance deployed medical capabilities and help conserve the fighting force of the U.S. Military and its partners.
IllustrisTNG in the HSC-SSP: image data release and the major role of mini mergers as drivers of asymmetry and star formation
Authors: Bottrell Connor , Yesuf Hassen M , Popping Gergö , Omori Kiyoaki Christopher , Tang Shenli , Ding Xuheng , Pillepich Annalisa , Nelson Dylan , Eisert Lukas , Gao Hua , Goulding Andy D , Kalita Boris S , Luo Wentao , Greene Jenny E , Shi Jingjing , Silverman John D 
Published: September 2023

ABSTRACT
At fixed galaxy stellar mass, there is a clear observational connection between structural asymmetry and offset from the star-forming main sequence, ΔSFMS. Herein, we use the TNG50 simulation to investigate the relative roles of major mergers (stellar mass ratios μ ≥ 0.25), minor (0.1 ≤ μ &lt; 0.25), and mini mergers (0.01 ≤ μ &lt; 0.1) in driving this connection amongst star-forming galaxies (SFGs). We use dust radiative transfer post-processing with SKIRT to make a large, public collection of synthetic Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) images of simulated IllustrisTNG (TNG) galaxies over 0.1 ≤ z ≤ 0.7 with log (M⋆/M⊙) ≥ 9 (∼750 k images). Using their instantaneous star formation rates (SFRs), known merger histories/forecasts, and HSC-SSP asymmetries, we show (1) that TNG50 SFGs qualitatively reproduce the observed trend between ΔSFMS and asymmetry and (2) a strikingly similar trend emerges between ΔSFMS and the time-to-coalescence for mini mergers. Controlling for redshift, stellar mass, environment, and gas fraction, we show that individual mini merger events yield small enhancements in SFRs and asymmetries that are sustained on long time-scales (at least ∼3 Gyr after coalescence, on average) – in contrast to major/minor merger remnants which peak at much greater amplitudes but are consistent with controls only ∼1 Gyr after coalescence. Integrating the boosts in SFRs and asymmetries driven by μ ≥ 0.01 mergers since z = 0.7 in TNG50 SFGs, we show that mini mergers are responsible for (i) 55 per cent of all merger-driven star formation and (ii) 70 per cent of merger-driven asymmetric structure. Due to their relative frequency and prolonged boost time-scales, mini mergers dominate over their minor and major counterparts in driving star formation and asymmetry in SFGs.
Autoactivation of mycorrhizal symbiosis signaling through gibberellin deactivation in orchid seed germination
Authors: Miura Chihiro , Furui Yuki , Yamamoto Tatsuki , Kanno Yuri , Honjo Masaya , Yamaguchi Katsushi , Suetsugu Kenji , Yagame Takahiro , Seo Mitsunori , Shigenobu Shuji , Yamato Masahide , Kaminaka Hironori 
Published: September 2023

Abstract
Orchids parasitically depend on external nutrients from mycorrhizal fungi for seed germination. Previous findings suggest that orchids utilize a genetic system of mutualistic arbuscular mycorrhizal (AM) symbiosis, in which the plant hormone gibberellin (GA) negatively affects fungal colonization and development, to establish parasitic symbiosis. Although GA generally promotes seed germination in photosynthetic plants, previous studies have reported low sensitivity of GA in seed germination of mycoheterotrophic orchids where mycorrhizal symbiosis occurs concurrently. To elucidate the connecting mechanisms of orchid seed germination and mycorrhizal symbiosis at the molecular level, we investigated the effect of GA on a hyacinth orchid (Bletilla striata) seed germination and mycorrhizal symbiosis using asymbiotic and symbiotic germination methods. Additionally, we compared the transcriptome profiles between asymbiotically and symbiotically germinated seeds. Exogenous GA negatively affected seed germination and fungal colonization, and endogenous bioactive GA was actively converted to the inactive form during seed germination. Transcriptome analysis showed that B. striata shared many of the induced genes between asymbiotically and symbiotically germinated seeds, including GA metabolism- and signaling-related genes and AM-specific marker homologs. Our study suggests that orchids have evolved in a manner that they do not use bioactive GA as a positive regulator of seed germination and instead autoactivate the mycorrhizal symbiosis pathway through GA inactivation to accept the fungal partner immediately during seed germination.
LRRK2 G2019S and Parkinson’s disease: insight from Neuroinflammation
Authors: Yao Xiao-Yan , Guan Li-Na , Chen Qi , Ren Chao 
Published: September 2023

Abstract
The multiple hypothesis holds that the pathogenesis of Parkinson’s disease (PD) requires many factors such as heredity, environment and ageing. Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized the risk factors of PD, and closely related to sporadic and familial PD and can regulate a variety of cellular pathways and processes. An Increasing number of studies has shown that glial hyperactivation-mediated neuroinflammation participates in dopaminergic neuron degeneration and pathogenesis of PD. LRRK2 is essential to the regulaton of chronic inflammation, especially for the central nervous system. The review spotlights on the novel development of LRRK2 on microglia and astrocytes, and explore their potential therapeutic targets, in order to provide a new insights in PD.
Key messages: What is already known on this topic The G2019S mutation of LRRK2 is now recognised as a pathogenic mutation in PD. Previous studies have focused on the relationship between neurons and LRRK2 G2019S. What this study adds Neuroinflammation mediated by LRRK2 G2019S of glial cells affects the progress and development of PD and attention must be paid to the role of LRRK2 G2019S in glial cells in PD. How this study might affect research, practice or policy Developing anti-inflammatory drugs from the perspective of LRRK2 G2019S of glial cells is a new direction for the treatment of PD.
Polymath: to be or not to be?
Authors: Kapsetaki Marianna Evangelia 
Published: September 2023

Abstract
Is it best to achieve excellence in one or multiple fields? Is it better to be a medical doctor reading only medical textbooks all your life or is it better to also tour around the world as a concert pianist and investigate the mysteries of the brain by conducting research projects? As a medical doctor, classical pianist, and neuroscientist, I discuss the advantages, disadvantages, opportunities, and challenges of pursuing multiple careers, drawing from my own experience and from polymaths of the past.