bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photosensitivity associated with treatment with triflusal
Authors: Nagore E , Pérez‐Ferriols A , Sánchez‐Motilla Jm , Serrano G , Aliaga A 
Published: March 2003

AbstractBackground Triflusal is a fluorinated aspirin derivative with antiplatelet properties, which is used in Spain for the management and prevention of thromboembolic disease.Case report A 91‐year‐old female developed a systemic photosensitivity reaction 15 days after beginning triflusal preventive treatment (300 mg/12 h) for prior transient ischaemic attack. Photobiological study showed an abnormal response to light in areas exposed to ultraviolet B and A radiation, with a photopatch test positive to both triflusal and its main metabolite. These observations suggested a causal relation between triflusal and the clinical findings, as described in previous reports.Conclusions The few cases reported to date and the clinicopathological features of this case suggested an immunological response as the most likely cause of the reaction.
Incorporation of ceramide 3B in dermatocosmetic emulsions: effect on the transepidermal water loss of sodium lauryl sulphate‐damaged skin
Authors: De Paepe Kristien , Derde Marie‐Paule , Roseeuw Diane , Rogiers Vera 
Published: March 2003

AbstractBackgroundIn previous work we reported on the efficacy of cosmetic body lotions enriched with skin‐identical lipids to reduce the transepidermal water loss (TEWL) of ageing and sodium lauryl sulphate (SLS)‐damaged skin. The observations made depended on the experimental design and clearly raised the question of the importance of the galenic formulation of skin ceramide‐containing products.ObjectivesThe aim of the present work was to study the different galenic forms in which ceramide 3B (0.2% w/v) can be incorporated into common o/w emulsions. In addition, we investigated whether supplementation of skin care products with ceramide 3B enriched with penetration enhancers and coemulsifiers could exert a beneficial effect on barrier function, done by measuring their effects on the TEWL of SLS‐induced scaly skin.ResultsWe found that the technique of incorporating ceramide 3B into the o/w emulsions was important for their final stability. However, no additional positive effect on the TEWL values of SLS‐damaged skin could be observed when the efficacy of the ceramide‐containing emulsions was compared with that of proper controls.ConclusionsAlthough suitable galenic formulas were developed, no positive effect on TEWL could be observed when ceramide 3B was added in a final concentration of 0.2% (w/v) to different o/w emulsions and applied to SLS‐damaged skin.
Superficial white onychomycosis in a 3‐year‐old human immunodeficiency virus‐infected child
Authors: Peña‐Penabad C , García‐Silva J , Almagro M , Del Pozo J , Fonseca E 
Published: March 2003

AbstractBackgroundSuperficial white onychomycosis is exceptional in children, although a few anecdotal cases have been reported in the literature. On the other hand, superficial white onychomycosis and proximal subungual onychomycosis, while unusual in the general population, often appear in adult human immunodeficiency virus (HIV)‐infected persons.Case reportA 3‐year‐old girl with vertically acquired HIV‐1 infection presented superficial white onychomycosis involving the second, third, fourth and fifth toes of her left foot, caused by Trichophyton rubrum. She was treated with topical amorolfine once a week, with a good response within 4 weeks.ConclusionsWe report a case of superficial white onychomycosis associated with HIV infection in a 3‐year‐old girl. To our knowledge, this type of onychomycosis has not been previously reported in HIV‐infected prepubertal children.
Recurrent intravascular papillary endothelial hyperplasia developing from a pyogenic granuloma
Authors: İnalöz HS , Patel G , Knight AG 
Published: March 2003

AbstractIntravascular papillary endothelial hyperplasia (IPEH) is a rare benign vascular tumour. Many histological features are similar to those of low‐grade angiosarcoma, a common, but more serious condition. Clinical and histological differentiation is important to avoid overtreatment of this benign condition. We report on a 34‐year‐old woman who developed recurrent IPEH at the site of a previously excised pyogenic granuloma.
Imiquimod 5% cream is an acceptable treatment option for external anogenital warts in uncircumcised males
Authors: Maw RD , Kinghorn GR , Bowman CA , Goh BT , Nayagam AT , Nathan M 
Published: March 2003

AbstractObjectives To determine the safety and efficacy of imiquimod (Aldara™) 5% cream in the treatment of prepuce‐associated warts in uncircumcised males.Methods An open‐label study in six UK medical centres with 35 uncircumcised males with prepuce‐associated warts treated with imiquimod 5% cream three times per week for up to 16 weeks. Other anogenital warts were also treated.Results Three times weekly application of imiquimod was found to be safe, with erythema as the most commonly reported local skin reaction. Forty per cent of patients had complete clearance of anogenital warts within 16 weeks.Conclusions Imiquimod cream at a dosing regimen of three times per week, is effective and has an acceptable safety profile in the treatment of prepuce associated warts and other external anogenital warts in uncircumcised males.
Treatment of vitiligo by topical calcipotriol
Authors: Chiavérini C , Passeron T , Ortonne JP 
Published: March 2003

AbstractObjective Evaluation of the efficiency of topical calcipotriol monotherapy in vitiligo.Materials and methods This was a prospective, right/left comparative, open study at the Dermatology Department at the University Hospital in Nice, France. Twenty‐four patients with localized or generalized vitiligo with symmetrical lesions were included. The main outcome measure was the evaluation of the percentage of repigmentation in treated target lesions and untreated control lesions for each patient.Results and conclusions Topical calcipotriol in monotherapy is not an effective treatment of vitiligo.
Polymorphous light eruption
Authors: Stratigos AJ , Antoniou C , Katsambas AD 
Published: March 2003

AbstractPolymorphous light eruption (PLE) is a common idiopathic photosensitivity disorder with an estimated prevalence of 10–20%. It is characterized by an intermittent skin reaction to ultraviolet (UV) radiation exposure, consisting of non‐scarring pruritic erythematous papules, vesicles or plaques that develop on light‐exposed skin. Despite the different morphology in different individuals, the eruption tends to have a monomorphous presentation in any single subject. The histopathological features of PLE are distinct and comprise a perivascular lymphocytic infiltrate in the dermis, subepidermal oedema and variable epidermal changes. The pathogenesis of PLE is not well known, but findings suggest that it is a delayed‐type hypersensitivity reaction to one or more UV‐modified cutaneous antigens. The principal action of PLE is mainly in the UVA region, although some subjects exhibit sensitivity to UVB alone or to both UVA and UVB radiation at the same time. Preventive measures in PLE include the regular use of photoprotective methods combined with graduated exposures to natural sunlight. The induction of immune tolerance by phototherapy and photochemotherapy are useful prophylactic methods in moderate to severe cases. The role of systemic agents in the management of PLE is under investigation. This article reviews the epidemiological, pathogenetic and clinical aspects of PLE and discusses recent advances in the diagnostic approach and management of this condition.
Collodion baby: a follow‐up study of 17 cases
Authors: Van Gysel D , Lijnen RLP , Moekti SS , De Laat PCJ , Oranje AP 
Published: March 2003

AbstractSeventeen cases of collodion baby are reported. Clinical aspects, complications, treatment, final outcome and family history were studied. We did not observe any clinical features in the collodion baby that could serve as a clue in predicting the final diagnosis. Infections were observed in nine, hypothermia in five and hypernatraemic dehydration in four cases. Skin infection mainly occurred in babies treated with emollients (petrolatum, lanolin and cetomacrogolis cream were used). We therefore recommend treating the collodion baby in a humidified incubator, if necessary with intravenous rehydration, but not to use emollients. The final outcome of these study patients was erythrodermic autosomal recessive lamellar ichthyosis in seven cases (41%), non‐erythrodermic autosomal recessive lamellar ichthyosis in three cases (18%), Sjögren–Larsson in one case (6%), epidermolytic hyperkeratosis in one case (6%), acute neonatal variant of Gaucher disease in one case (6%) and normal skin in four cases (24%).
Efficacy of erbium YAG laser‐assisted autologous epidermal grafting in vitiligo
Authors: Pai GS , Vinod V , Joshi A 
Published: March 2003

ABSTRACTBackground Of the various modalities of therapy available for the treatment of vitiligo, a combination of psoralen + ultraviolet A (PUVA) with autologous epidermal grafting appears to offer the best results. The erbium YAG laser can be used to prepare the recipient site in both punch grafting and suction blister grafting.Methods In this study 29 subjects, 26 with localized and three with generalized stable vitiligo, had received pregrafting PUVA and underwent further PUVA starting 2 weeks after surgery until maximal pigmentation was achieved. The erbium YAG laser was used on 16 subjects; the recipient site for punch grafting was prepared with laser and minigrafts harvested by manual punch were placed into the prepared sites. For suction blister grafting, the site was dermabraded with a laser and the harvested blister roof (created using suction apparatus) was transplanted on to the site.Results More than two‐thirds (68.75%) of the subjects who were punch grafted using a laser showed repigmentation of more than 75%, but only one‐half of those who underwent conventional punch grafting showed a similar response. All subjects with laser‐assisted suction blister grafting showed a good response, compared with only 60% of those who underwent conventional suction blister grafting.Conclusions The results obtained with laser‐assisted grafting are more satisfactory than those achieved with conventional grafting techniques. We found that the repigmentation zones are larger (up to 9 mm in the former vs. 3 mm in the latter) and cobblestoning does not occur with laser‐assisted grafting. Also, the procedure is precise, relatively atraumatic and can be performed rapidly even when covering vast areas.
Sebaceus naevi: a clinicopathologic study
Authors: Muñoz‐Pérez MA , García‐Hernandez MJ , Ríos JJ , Camacho F 
Published: March 2003

AbstractObjective To analyse sebaceus naevus (SN) incidence, associated malignancies, and developmental defects in a retrospective study.Methods We retrospectively analysed all cases of SN excised in our Department over a 20‐year period. All cases of epidermal naevus syndrome (Schimmelpenning syndrome) associated with SN were recorded, as well as all patients with histological changes suggesting degeneration of the initial SN.Result A total 226 patients with SN were included in the study. Stage II was the most common (65%), and the parietal area was the most common location of SN (42%), with only 7% located in non‐scalp areas. Syringocystadenoma papilliferum and trichoblastoma were the most common tumours arising on SN. We only found five patients with basal cell carcinoma arising on previous SN. Epidermal naevus syndrome associated with SN was diagnosed in 16 patients, and this was the most common neurocutaneous association.Conclusion The incidence of malignancy arising on SN was very low, indicating that prophylactic surgery of NS in children is not recommendable. Developmental defects should be investigated in order to evidence possible epidermal naevus syndrome associated with SN.
Comparative biochemistry of human skin: glycosaminoglycans from different body sites in normal subjects and in patients with localized scleroderma
Authors: Passos CO , Werneck CC , Onofre GR , Pagani EA , Filgueira AL , Silva L‐CF 
Published: March 2003

ABSTRACTObjectives The aim of this investigation is to compare the relative proportions of disaccharides of chondroitinase‐digestible glycosaminoglycans (GAGs) among the different body sites in control human skin and in the skin lesions of patients with localized scleroderma.Methods The disaccharide relative proportions were determined using high‐performance liquid chromatography (HPLC).Results ΔDi‐4S, the main disaccharide unit of dermatan sulphate (DS), was the major skin GAG disaccharide (∼70% of the total) in control skin among all different body sites studied here. In scleroderma there was an increase in the relative proportion of both ΔDi‐HA, the main disaccharide unit of hyaluronic acid (HA), and ΔDi‐diSB (α‐ΔUA(2SO4)‐1→3‐GalNAc(4SO4)), derived from DS, and a decrease in ΔDi‐4S, as compared with the uninvolved skin or the site‐matched control skin.Conclusion DS is the major GAG species in normal skin from different body sites. In addition, our results suggest a decrease and also a structural change in DS and an increase in the proportion of HA in scleroderma skin.
Merkel cell carcinoma – a retrospective analysis of 17 cases
Authors: Hohaus K , Köstler E , Schönlebe J , Klemm E , Wollina U 
Published: March 2003

ABSTRACTObjective To report clinical experience with the rare neuroendocrine Merkel cell carcinoma of the skin.Subjects and setting Seventeen patients with Merkel cell carcinoma of the skin treated at the Departments of Dermatology and ENT, Krankenhaus Dresden‐Friedrichstadt, Dresden, Germany, during the years 1984–2000 were evaluated.Methods A retrospective analysis was performed. Age and sex distribution, clinical data and therapy were collected. Outcome measures including overall survival, tumour‐free survival and relapse‐free survival were determined.Results Six male and 11 female patients with an age range of 68–90 years (mean age 73.3 years) were identified. The primary tumour localization was head and neck region (n = 8), upper limbs (8), lower limbs (1). Twelve patients presented in tumour stage I, three in stage II and one in stage III. First line therapy was complete surgical excision with wide margins in 16 patients followed by loco‐regional radiation in 12 of 16 cases. In 16 patients follow up data were available. After primary treatment complete response was achieved in 14 of 16 patients (87.5%), two patients had a partial response. The median of relapse‐free survival was 44 weeks [mean ± standard deviation: (44 ± 118) weeks]. The median of overall survival was 102 weeks [mean ± standard deviation: (137 ± 94) weeks]. Three patients with a PR after primary treatment had a median overall survival of only 48 weeks [mean ± standard deviation: (51 ± 20) weeks].Conclusions Primary surgical treatment with wide excision combined with radiotherapy seems to be a reasonable first‐line treatment but prospective controlled multicentre trials are necessary for validation.
Age Recognition in Adults with Intellectual Disabilities: a Literature Review and an Exploratory Study
Authors: Bell Dorothy M. , Espie Colin A. 
Published: March 2003

AbstractThe ability of children to classify accurately their own ages and the ages of others has been the subject of very limited research. However, the literature is largely in agreement on there being progressive increases in skill with chronological age, although there is disagreement on the age at which this ability becomes well developed. The processes look similar in the field of intellectual disabilities, although this area is extremely under‐researched. Key factors may include age, the amount of time spent in institutions (e.g. long‐term hospitals for people with intellectual disabilities), developmental level and IQ. The present paper provides a review of the relevant literature and an exploratory study investigating the age recognition of self and colleagues in a group of 20 adults with intellectual disability, some from within what has been a major hospital for people with intellectual disabilities and some from the wider community. Measures of age recognition using photographs, as well as standardized measures of intellectual ability and social adaptive behaviour, were administered, and correlations were found between the ability to recognize age in others and developmental age, and also IQ. Success on the task of age discrimination appears to be more likely if the IQ of the individual is around 60–65 or above, and if the person shows social adaptive behaviour equivalent to 8 or 9 years of age and over. Also included in the study was a task in which only the discrimination of whether the photographs were of adults or children was required, and this proved to be a simpler process for the participants. The present study also demonstrates some of the discriminative stimuli used by adults with intellectual disabilities to ascertain the approximate age of a person.
Assessment and Intervention to Teach Age Recognition Skills: a Suggested Programme Using the Example of a Case Study to Illustrate
Authors: Bell Dorothy M. , Espie Colin A. 
Published: March 2003

AbstractA 43‐year‐old man with mild intellectual disabilities was referred after several contacts with the law when he had been seen in the street talking to children who were unknown to him. Some staff members feared that he had a sexual interest in children. Other colleagues considered that the behaviour was innocent, reflecting his friendly nature, but that it was a behaviour which was misinterpreted by others. The present paper charts the assessment of this man's difficulties and abilities over a wide range of relevant areas, and a reassessment following an intensive period of one‐to‐one training on age‐recognition skills. Although the training was unsuccessful, the measures used assisted in making a detailed assessment and providing clear instructions to care staff, all of which was to the subject's long‐term benefit. The present paper also illustrates the way in which difficulties of this nature can be assessed and uses allied assessment measures which may be helpful in looking at the whole picture of any person with such problems. It also considers how these areas may then be addressed. Although, in this case, the subject was unable to learn to discriminate specific age groups despite intensive training, he was consequently able to be advised in a manner which should keep him from getting into trouble in the future and the now detailed knowledge of his abilities in all these areas is valuable for his long‐term support in the community.
Ultrasound findings in gestations destined for unanticipated fetal demise
Authors: Dombrowski M. P. , Bottoms S. F. , Zador I. , Wolfe H. M. , Sokol R. J. 
Published: March 2003

AbstractThere are few reports of ultrasound findings in the second and third trimesters preceding intrauterine fetal demise. To describe these findings, the ultrasound assessments of 36 structurally normal singleton fetuses with subsequent intrauterine fetal demise were compared to gestational age‐matched controls. Compared to controls, it was found that biparietal diameter, head circumference, femur length and estimated fetal weight were all decreased, abnormalities of amniotic fluid volume were more frequent, but the cephalic index was not different. Upon delivery, the group with subsequent intrauterine fetal demise was not found to have any major anomalies, but had a high incidence of abnormal umbilical cord position, abruptio placentae, chorioamnionitis and meconium aspiration. Copyright © 1991 International Society of Ultrasound in Obstetrics and Gynecology
Prenatal sonographic diagnosis and perinatal management of ectopia cordis
Authors: Achiron R. , Shimmel M. , Farber B. , Glaser J. 
Published: March 2003

AbstractEctopia cordis is a rare malformation presenting as an isolated lesion or as part of the Cantrell's pentology syndrome. Prenatal ultrasonographic diagnosis of ectopia cordis must be followed by a careful search for associated anomalies, since the prognosis may vary accordingly. A case of prenatal diagnosis of ectopia cordis in the early second trimester is presented. Routine sonographic examination at 18 weeks of gestation revealed protrusion of the heart into the amniotic fluid, ventricular septal defect and omphalocele. The perinatal evaluation and management are discussed. Copyright © 1991 International Society of Ultrasound in Obstetrics and Gynecology
Absence of fetal breathing and abnormal fetal behavior in prolonged preterm ruptured membranes: case report
Authors: Pillai M. , James D. 
Published: March 2003

AbstractA case is described where prolonged serial observations were carried out on a fetus, between 26 and 3.5 weeks' gestation, the membranes having been ruptured from 23 weeks. No fetal breathing or cyclical activity was observed, and there was no evidence of development of linkage between the fetal behavioral state variables. This was not associated with respiratory morbidity in the neonatal period, but subsequently with severe developmental delay, microcephaly, myoclonic epilepsy and hearing impairment. Absence of fetal breathing may be a more important predictor of prenatal neurological abnormality than of respiratory morbidity following birth. Copyright © 1992 International Society of Ultrasound in Obstetrics and Gynecology
Nuchal cord in normal third‐trimester pregnancy: a color Doppler imaging study
Authors: Jauniaux E. , Mawissa C. , Peellaerts C. , Rodesch F. 
Published: March 2003

AbstractA prospective study was performed in a normal, unselected, population of 180 pregnant women to assess the screening properties of color Doppler imaging in the detection of nuchal cord during the third trimester of pregnancy. A search was made for the umbilical cord position initially using conventional real‐time gray‐scale imaging and subsequently using color imaging. Umbilical artery resistance and pulsatility indices and maximum peak systolic velocity were measured in each case at the level of the placental cord insertion. Forty‐five (25%) cases examined using color imaging presented with a nuchal cord at both ultrasound examination and delivery. Color imaging correctly identified in utero 28 (72%) single and 17 (94%) multiple nuchal cords found at birth. The overall sensitivity of color imaging in detecting nuchal cord prenatally was greater than for gray‐scale imaging (79% compared with 33%). The sensitivity of color imaging was also higher after 36 weeks than before (93% compared with 67%). No difference was observed between the umbilical artery resistance and pulsatility indices. There was also no difference observed for the maximum peak systolic velocity between cases presenting with a nuchal cord (at both ultrasound examination and delivery) and controls matched for gestational age. We suggest that the clinical usefulness of systematic identification in utero of nuchal cord in pregnancies presenting with a normal fetus in the vertex position is limited, but might be of value in the management of breech and twin gestations, and also in the management of chronically growth‐retarded fetuses. Copyright © 1992 International Society of Ultrasound in Obstetrics and Gynecology