bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding community leaders’ and program coordinators’ perceptions of and needs from a community systems map: a qualitative study
Authors: Lo Margret , Ross Natasha , Anand Sonia S. , de Souza Russell J , Wahi Gita , Desai Dipika , Kandasamy Sujane , Sherifali Diana , DiLiberto Deborah , Newbold K. Bruce , Crea-Arsenio Mary , Montague Patty , Jackson-Best Fatimah 
Published: January 2024

AbstractObjectivesA systems map for the Riverdale community in Hamilton, Ontario has documented programs, activities, and spaces for healthy, nature-based activities. A systems map was created to provide an approachable resource for community members. As a means of understanding whether this map would prove useful, interviews with community and organization leaders were conducted. The objectives of this study were to 1) characterize user engagement with recreational and active living programs and services located in and around the Riverdale community, 2) determine existing barriers to and facilitators of accessing recreational and active living programs for those in the Riverdale community, as perceived by those who deliver programs and, 3) improve the functionality and usability of the system map, including any information or services that may be missing.□□MethodsTwenty 60-minute semi-structured interviews were conducted with community leaders and program coordinators who focus on healthy active living and work within the Riverdale community.ResultsWe learned that Riverdale programming is typically gender-specific, women-dominated, and targeted to children and youth. Additionally, cost, transportation and accessibility, and language were the greatest barriers to accessing recreational programming. Conversely, facilitators for program involvement included transportation assistance, compensation, and food provision. Finally, interviews revealed the need for sustainability, clarity, and language options within the systems map.ConclusionThis work procured the necessary information to edit the interactive systems map according to community needs. With this map, Riverdale community members are able to access a source of information about activities and services.
Quality of maternal care at public health centers of Siltie zone, Central Ethiopia 2022
Authors: Mohammednur Abdulfeta Shafi , Abdu Neima Ridwan 
Published: January 2024

AbstractIntroductionQuality of care is “the extent to which health care services provided to individuals and patient populations improve desired health outcomes. In order to achieve this, health care must be safe, effective, timely, efficient, equitable and people-centered (WHO). Quality care is crucial in ensuring that women and newborns receive interventions that may prevent and treat birth-related complications. This paper assessed the quality of maternal care at public health facilities of Siltie zone, Central Ethiopia, from March 1 up to April, 15, 2023.Methodfacility based Cross sectional study design was conducted. Under this study totally 437 individuals’, 367 mothers and 70 health care providers in 23 health center were interviewed. All woreda and city administrates were included in the study contributing at least one health center. The data collection tool was adopted from health sector transformation in quality in Ethiopia (HSTQ). Specific health center maternal health care quality score was obtained by the total score of the health center performed divided by the total score expected (excluding NA quality measures) and the result was multiplied by 100%.ResultOverall quality of sanitation facility in health center is 71% and the overall quality of care service based on the health care provider is almost 80.7%. Quality of prenatal health care service is 83%, Labor and Newborn care is 87%, postpartum care 87%and Facility inventory 77%. The overall quality of maternal care is 82%.ConclusionQuality of maternal and newborn health care service is good. Further efforts are needed to improve availability of necessary equipment’s, electricity and water supply.
Validation of the Food Safe Zone Questionnaire for Families of Individuals with Prader-Willi syndrome
Authors: Dykens Elisabeth M , Roof Elizabeth , Hunt-Hawkins Hailee 
Published: January 2024

AbstractPrader-Willi syndrome (PWS), a genetic neurodevelopmental disorder, is characterized by hyperphagia and significant behavioral problems. Hyperphagic individuals with PWS are chronically hungry yet rarely feel sated, and often engage in food-seeking behaviors. To avoid obesity in their children, families implement food security and supervision strategies (e.g., locking food sources, alerting others). Yet such accommodations may undermine parental appraisals of hyperphgia (e.g., it’s not a problem as we lock food); a potential confound in clinical trials aimed at attenuating hyperphagia. We developed the Food Safe Zone (FSZ) questionnaire to remind parents of their food safety practices prior to them evaluating their child’s hyperphagia.Our team developed 20 FSZ items that were revised for clarity and completeness in an iterative feedback process with stakeholders; parents, PWS specialists, and individuals with PWS. The FSZ was pilot tested, descriptive findings were reviewed by additional stakeholders, and then administered to 624 parents in a large-scale study. Based on an open-ended question, “Is there anything else you do to ensure food safety?” two additional items were added and evaluated in a follow-up study.Principal component analyses revealed that 21 FSZ items loaded onto 5 factors that were readily interpretable, accounting for 67% of test variance: Alerting Others and Food Supervision in the Community; Locking or Restricting Food Sources; Checking for Food; At Home Supervision and Meals; and Avoiding Food Settings. Internal consistency and test-rest reliability were robust. Convergent validity analyses revealed that regardless of age, parents implemented more FSZ strategies in response to the severity of their child’s hyperphagia.The psychometrically sound FSZ stands to enhance accurate parental assessments of hyperphagia in future studies or clinical trials. Analyses of the open-ended question also shine a light on the extraordinary measures that parents use to ensure the health of their individual with PWS.
Physical activity and prevalence of constipation in Japanese young people
Authors: Watanabe Junichi , Furukawa Shinya , Yamamoto Yasunori , Kato Aki , Kusumoto Katsunori , Takeshita Eiji , Ikeda Yoshio , Yamamoto Naofumi , Saeki Yuka , Miyake Teruki , Yoshida Osamu , Hiasa Yoichi 
Published: January 2024

AbstractBackgroundConstipation is a very common medical issue among general humans worldwide. The association between physical activity (PA) and constipation is still inconsistent. Additionally, no evidence regarding this issue in young population.AimsThis study aimed to evaluate the association between self-reported physical activity and constipation in Japanese young population, taking the presence or absence of an exercise partner as an additional variable.MethodsThe study subjects consisted of 12497 Japanese university students. Information on constipation, exercise frequency, exercise intensity, and exercise partners was obtained from a self-administered questionnaire. Age, sex, body mass index, drinking, smoking, anemia, and sports injury were selected as potential confounding factors.ResultsThe prevalence of constipation was 6.5% in this cohort. Low, moderate, and high frequency of exercise was independently inversely associated with constipation (adjusted odds ratios [a OR] were low: a OR 0.77 [95% confidence interval (CI) 0.63–0.94], moderate: a OR 0.75 [95% CI 0.60–0.94] and high: a OR 0.70 [95% CI 0.53–0.91], p for trend p=0.002). Low, moderate, and high intensity of exercise was independently inversely associated with constipation (low: a OR 0.77 [95% CI 0.62–0.97], moderate: a OR 0.77 [95% CI 0.63–0.95] and high: a OR 0.70 [95% CI 0.53–0.87], p for trend p=0.001). Exercise with groups and with friends was independently inversely associated with constipation whereas the association between exercising alone and constipation was not significant (groups: a OR 0.70 [95% CI 0.53–0.90] and friends: a OR 0.56 [95% CI 0.42–0.74])ConclusionIn the young Japanese population, frequency and intensity of exercise and presence of exercise partner might be independently inversely associated with constipation.
Wearable Sensor and Digital Twin Technology for the Development of a Personalized Digital Biomarker of Vaccine-Induced Inflammation
Authors: Steinhubl Steven R. , Sekaric Jadranka , Gendy Maged , Guo Huaijian , Ward Matthew P. , Goergen Craig J. , Anderson Jennifer L. , Amin Sarwat , Wilson Damen , Paramithiotis Eustache , Wegerich Stephan 
Published: January 2024

AbstractEffective response to vaccination requires activation of the innate immune system, triggering the synthesis of inflammatory cytokines. The subjective symptoms related to this, referred to as reactogenicity, affect a variable percentage of vaccinated people to different degrees, with evidence supporting a relationship between the severity of symptoms a person experiences and their eventual immune response. Wearable sensors allow for the identification of objective evidence of physiologic changes a person experiences in response to vaccine-induced inflammation, but as these changes are subtle, they can only be detected when an individual’s pre-vaccination normal variability is considered. We used a wearable torso sensor patch and a machine learning method of similarity-based modeling (SBM), which learns the dynamic interplay between multivariate input sources, to create a physiologic digital twin for 88 people receiving 104 vaccine doses. By effectively removing expected variations and leaving only vaccine-induced differences, we developed a multivariate digital biomarker that incorporates changes in multiple continuously monitored physiologic data streams to measure the degree and duration of vaccine induced inflammation. This objective measure correlated with subjective symptoms, and in a 20-person subset, both humoral and cellular immunogenicity.
Modeling lesion transition dynamics to clinically characterize mpox patients in the Democratic Republic of the Congo
Authors: Nishiyama Takara , Miura Fuminari , Jeong Yong Dam , Nakamura Naotoshi , Park Hyeongki , Ishikane Masahiro , Yamamoto Shotaro , Iwamoto Noriko , Suzuki Michiyo , Sakurai Ayana , Aihara Kazuyuki , Watashi Koichi , Hart William S , Thompson Robin N , Yasutomi Yasuhiro , Ohmagari Norio , Kingebeni Placide Mbala , Huggins John W. , Iwami Shingo , Pittman Phillip R. 
Published: January 2024

AbstractCoinciding with the global outbreak of clade IIb mpox virus (MPXV), the Democratic Republic of the Congo (DRC) recently experienced a rapid surge in mpox cases with clade I MPXV. Clade I MPXV is known to be more fatal, but its clinical characteristics and prognosis differ between patients. Here, we used mathematical modelling to quantify disease progression in a large cohort of mpox patients in the DRC from 2007-2011, particularly focusing on lesion transition dynamics. We further analyzed individuals’ clinical data to find predictive biomarkers of severity of symptoms. Our analysis shows that mpox patients can be stratified into three groups according to symptom severity, and that viral load at symptom onset may serve as a predictor to distinguish groups with the most severe or mild symptoms after progression. Understanding the severity and duration of symptoms in different patients, as characterized by our approach, allows treatment strategies to be improved and individual-specific control measures (e.g isolation strategies based on disease progression) to be developed.
4D structural biology: quantitative dynamics in the eukaryotic RNA exosome complex
Authors: Liebau Jobst , Lazzaretti Daniela , Fürtges Torben , Bichler Anna , Pilsl Michael , Rudack Till , Sprangers Remco 
Published: January 2024

AbstractMolecular machines play pivotal roles in all biological processes. Most structural methods, however, are unable to directly probe molecular motions. Here, we demonstrate that dedicated NMR experiments can provide quantitative insights into functionally important dynamic regions in very large asymmetric protein complexes. We establish this for the 410 kDa eukaryotic RNA exosome complex that contains ten distinct protein chains. Methyl-group and fluorine NMR experiments reveal site-specific interactions among subunits and with an RNA substrate. Furthermore, we extract quantitative insights into conformational changes within the complex in response to substrate and subunit binding for regions that are invisible in static cryo-EM and crystal structures. In particular, we identified a flexible plug region that can block an aberrant route of RNA towards the active site. Based on molecular dynamics simulations and NMR data we provide a model that shows how the flexible plug is structured in the open and closed conformations. Our work thus demonstrates that a combination of state-of-the-art structural biology methods can provide quantitative insights into large molecular machines that go significantly beyond the well-resolved and static images of biomolecular complexes, thereby adding the time domain into structural biology.
Expanding the RNA polymerase biocatalyst solution space for mRNA manufacture
Authors: Curry Edward , Sedelnikova Svetlana , Rafferty John , Hulley Martyn , Brown Adam 
Published: January 2024

AbstractAll mRNA products are currently manufactured inin vitrotranscription (IVT) reactions that utilize single-subunit RNA polymerase (RNAP) biocatalysts. Although it is known that discrete polymerases exhibit highly variable bioproduction phenotypes, including different relative processivity rates and impurity generation profiles, only a handful of enzymes are generally available for mRNA biosynthesis. This limited RNAP toolbox restricts strategies to design and troubleshoot new mRNA manufacturing processes, which is particularly undesirable given the continuing diversification of mRNA product lines towards larger and more complex molecules. Herein, we describe development of a high-throughput RNAP screening platform, comprising complementaryin silicoandin vitrotesting modules, that enables functional characterisation of large enzyme libraries. Utilizing this system, we identified eight novel sequence-diverse RNAPs, with associated active cognate promoters, and subsequently validated their performance as recombinant enzymes in IVT-based mRNA production processes. By increasing the number of available characterized functional RNAPs by > 130% and providing a platform to rapidly identify further potentially useful enzymes, this work significantly expands the RNAP biocatalyst solution space for mRNA manufacture, thereby enhancing capability to achieve application and molecule-specific optimisation of product yield and quality.
Synaptic motility and functional stability in the whisker cortex
Authors: Sherf Nimrod , Shamir Maoz 
Published: January 2024

The high motility of synaptic weights raises the question of how the brain can retain its functionality in the face of constant synaptic remodeling. Here we used the whisker system of rats and mice to study the interplay between synaptic plasticity (motility) and the transmission of sensory signals downstream.Rats and mice probe their surroundings by rhythmically moving their whiskers back and forth. The azimuthal position of a whisker can be estimated from the activity of whisking neurons that respond selectively to a preferred phase along the whisking cycle. These preferred phases are widely distributed on the ring. However, simple models for the transmission of the whisking signal downstream predict a distribution of preferred phases that is an order of magnitude narrower than empirically observed. Here, we suggest that synaptic plasticity in the form of spike-timing-dependent plasticity (STDP) may provide a solution to this conundrum. This hypothesis is addressed in the framework of a modeling study that investigated the STDP dynamics in a population of synapses that propagates the whisking signal downstream.The findings showed that for a wide range of parameters, STDP dynamics do not relax to a fixed point. As a result, the preferred phases of downstream neurons drift in time at a non-uniform velocity which in turn, induces a non-uniform distribution of the preferred phases of the downstream population. This demonstrates how functionality, in terms of the distribution of preferred phases, can be retained not simply despite, but because of the constant synaptic motility. Our analysis leads to several key empirical predictions to test this hypothesis.
Understanding the intricacies of risky indebtedness, impulse buying and perceived risk in buy-now-pay-later adoption
Authors: Kumar Syam , Nayak Jogendra Kumar 
Published: January 2024

PurposeThis study aims to establish that the relationship between the risky indebtedness behavior (RIB) of consumers and their attitude toward adopting buy-now-pay-later (BNPL) is not immediate but is mediated through impulse buying. Moreover, it explores how perceived risk moderates the association between the attitude to adopt BNPL and its adoption intention.Design/methodology/approachThis study used the existing theoretical and empirical evidence to propose a model and validated it using the data collected from 339 young shoppers in India. Analysis of data is conducted using partial least squares structural equation modeling.FindingsThe study results show that consumers’ RIB is not directly related to their attitude toward BNPL. However, impulse buying fully mediates this relationship, influencing the attitude toward BNPL. Impulse buying and attitude serially mediate the relationship between RIB and BNPL adoption intention. Further, in the context of BNPL, perceived risk strengthens the attitude-intention gap.Practical implicationsThis study advises policymakers and BNPL providers to carefully assess users’ creditworthiness to prevent those already in debt from entering into a detrimental loop.Originality/valueThis study provides novel perspectives on consumer’s RIB and BNPL within the Indian context. The study additionally identifies the mediating influence of impulse buying and the moderating effect of perceived risk on BNPL adoption intention.
Community relations discovery methods for users in Fancircle based on sentiment analysis in China
Authors: Wang Kai 
Published: January 2024

PurposeThe identification of network user relationship in Fancircle contributes to quantifying the violence index of user text, mining the internal correlation of network behaviors among users, which provides necessary data support for the construction of knowledge graph.Design/methodology/approachA correlation identification method based on sentiment analysis (CRDM-SA) is put forward by extracting user semantic information, as well as introducing violent sentiment membership. To be specific, the topic of the implementation of topology mapping in the community can be obtained based on self-built field of violent sentiment dictionary (VSD) by extracting user text information. Afterward, the violence index of the user text is calculated to quantify the fuzzy sentiment representation between the user and the topic. Finally, the multi-granularity violence association rules mining of user text is realized by constructing violence fuzzy concept lattice.FindingsIt is helpful to reveal the internal relationship of online violence under complex network environment. In that case, the sentiment dependence of users can be characterized from a granular perspective.Originality/valueThe membership degree of violent sentiment into user relationship recognition in Fancircle community is introduced, and a text sentiment association recognition method based on VSD is proposed. By calculating the value of violent sentiment in the user text, the annotation of violent sentiment in the topic dimension of the text is achieved, and the partial order relation between fuzzy concepts of violence under the effective confidence threshold is utilized to obtain the association relation.
A Hamiltonian equation produces a variety of Painlevé integrable equations: solutions of distinct physical structures
Authors: Wazwaz Abdul-Majid 
Published: January 2024

Purpose
The purpose of this paper is to investigate a variety of Painlevé integrable equations derived from a Hamiltonian equation.

Design/methodology/approach
The newly developed Painlevé integrable equations have been handled by using Hirota’s direct method. The authors obtain multiple soliton solutions and other kinds of solutions for these six models.

Findings
The developed Hamiltonian models exhibit complete integrability in analogy with the original equation.

Research limitations/implications
The present study is to address these two main motivations: the study of the integrability features and solitons and other useful solutions for the developed equations.

Practical implications
The work introduces six Painlevé-integrable equations developed from a Hamiltonian model.

Social implications
The work presents useful algorithms for constructing new integrable equations and for handling these equations.

Originality/value
The paper presents an original work with newly developed integrable equations and shows useful findings.
Promoting fintech: driving developing country consumers’ mobile wallet use through gamification and trust
Authors: Rahman Saleem ur , Nguyen-Viet Bang , Nguyen Yen Thi Hoang , Kamran Sohail 
Published: January 2024

PurposeM-wallets have emerged as one of the most important financial innovations of the 21st century, enabling users to carry digital cash by securely storing payment methods on their mobile devices. However, the continued use of m-wallets varies among people for several reasons. This study used the technology continuation theory (TCT), gamification and trust factors to examine the variables affecting consumers' intentions to continue using mobile wallets.Design/methodology/approachThe SmartPLS partial least squares software was used to analyze data from 431 m-wallet users in Vietnam using the structural equation modeling technique.FindingsThe data revealed that the research model can predict users' intentions to continue using mobile wallets. TCT constructs demonstrated strong exploratory power in explaining consumer satisfaction and attitudes towards m-wallets. Furthermore, the study confirmed the direct effect of the perceived effectiveness of gamification on perceived ease of use and attitude, as well as its indirect effect on consumers' continued use intentions of mobile wallets via attitude. In addition, the trust negatively influenced consumers' intentions to continue using m-wallets.Practical implicationsThe findings of this study can help researchers, practitioners and policymakers improve m-wallet design, development and adoption, as well as advance financial technology and define the future of digital payments in terms of consumer attraction, engagement and financial inclusion.Originality/valueBased on TCT theory, this study enriches m-wallet research by examining two important factors, gamification and trust, and thus provides insights into how to improve consumers’ intentions to continue using m-wallets in developing countries. This study offers timely insights into theory and practice regarding these factors. It therefore paves the way for researchers and practitioners to learn how easy, enjoyable and secure the end-user experience should be to keep users engaged with m-wallets.