bluuebunny/crossref_metadata_2025_split huggingface dataset:
LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease
Authors: Xu Zheng-Yuan , Wang Jin-Chun 
Published: October 2023

Abstract
Background
The aim of this study was to explore the mechanism whereby LACC1 regulates the intestinal flora in a mouse model of inflammatory bowel disease (IBD).

Methods
C57BL/6 and Lacc1−/− mice were used to establish a mouse model of IBD induced by dextran sodium sulfate (DSS). The effects of Lacc1 deletion in mice were evaluated. Changes in the body weight and stool blood were recorded daily. After 7 days of successful modeling, the mice were sacrificed, blood was collected from the eyeballs, the entire colon was dissected and separated, and the length of the colon was measured.

Results
Compared with the wild-type (WT) DSS model group, the Lacc1−/− DSS model group showed a significantly higher disease activity index score (P < 0.05), significantly faster weight loss (P < 0.05), and a significantly shorter colon (P < 0.05), indicating that the colonic mucosal tissue was seriously damaged in the Lacc1−/− DSS model group (P < 0.05). Serum IL-1β, IL-6, TNF-α, and IFN-γ levels were significantly higher in the Lacc1−/− DSS model group than the WT DSS model group. Principal coordinate analysis showed that there were significant microbiome differences between the WT, Lacc1−/−, WT DSS model, and Lacc1−/− DSS model groups (P < 0.05). Linear discriminant analysis effect size analysis showed that under natural conditions, Lacc1−/− mice had significant changes in their intestinal flora compared with control mice (LDA value > 3 or < 3, P < 0.05).

Conclusions
Lacc1 deletion aggravates DSS-induced IBD in mice.
A meta-analysis on the therapeutic efficacy of repetitive transcranial magnetic stimulation for cognitive functions in attention-deficit/hyperactivity disorders
Authors: Chen Ying-Hsin , Liang Shun-Chin , Sun Cheuk-Kwan , Cheng Yu-Shian , Tzang Ruu‐Fen , Chiu Hsien‐Jane , Wang Ming-Yu , Cheng Ying-Chih , Hung Kuo-Chuan 
Published: October 2023

Abstract
Background
Therapeutic efficacies of repetitive transcranial magnetic stimulation (rTMS) for improving cognitive functions in patients with deficit/hyperactivity disorder (ADHD) remained unclear. The aim of this meta-analysis was to investigate the therapeutic efficacy of rTMS focusing on different cognitive performances.

Methods
Major databases were searched electronically from inception to February 2023 by using keywords mainly “rTMS” and “ADHD” to identify randomized controlled trials (RCTs) that investigated the therapeutic efficacy of rTMS for improving cognitive functions assessed by standardized tasks in patients with ADHD. The overall effect size (ES) was calculated as standardized mean difference (SMD) based on a random effects model.

Results
Meta-analysis of five RCTs with 189 participants (mean age of 32.78 and 8.53 years in adult and child/adolescent populations, respectively) demonstrated that rTMS was more effective for improving sustained attention in patients with ADHD compared with the control groups (SMD = 0.54, p = 0.001).Our secondary analysis also showed that rTMS was more effective for improving processing speed than the control groups (SMD = 0.59, p = 0.002) but not for enhancing memory or executive function.

Conclusions
Our results supported the therapeutic efficacy of rTMS for improving sustained attention and processing speed. However, the limitation of available data warrants further studies to verify these findings.
Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation
Authors: Mughrabi Ibrahim T. , Gerber Michael , Jayaprakash Naveen , Palandira Santhoshi P. , Al-Abed Yousef , Datta-Chaudhuri Timir , Smith Corey , Pavlov Valentin A. , Zanos Stavros 
Published: October 2023

Abstract
Background
The noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of neurostimulation therapies for inflammatory diseases. However, there is no real-time marker of its successful activation, which hinders the development of anti-inflammatory neurostimulation therapies and mechanistic studies in anti-inflammatory neural circuits.

Methods
In mice, we performed fast-scan cyclic voltammetry (FSCV) in the spleen during intravenous injections of norepinephrine (NE), and during stimulation of the vagus, splanchnic, or splenic nerves. We defined the stimulus-elicited charge generated at the oxidation potential for NE (~ 0.88 V) as the “NE voltammetry signal” and quantified the dependence of the signal on NE dose and intensity of neurostimulation. We correlated the NE voltammetry signal with the anti-inflammatory effect of splenic nerve stimulation (SpNS) in a model of lipopolysaccharide- (LPS) induced endotoxemia, quantified as suppression of TNF release.

Results
The NE voltammetry signal is proportional to the estimated peak NE blood concentration, with 0.1 μg/mL detection threshold. In response to SpNS, the signal increases within seconds, returns to baseline minutes later, and is blocked by interventions that deplete NE or inhibit NE release. The signal is elicited by efferent, but not afferent, electrical or optogenetic vagus nerve stimulation, and by splanchnic nerve stimulation. The magnitude of the signal during SpNS is inversely correlated with subsequent TNF suppression in endotoxemia and explains 40% of the variance in TNF measurements.

Conclusions
FSCV in the spleen provides a marker for real-time monitoring of anti-inflammatory activation of the splenic innervation during autonomic stimulation.
Application of deep learning technique in next generation sequence experiments
Authors: Özgür Su , Orman Mehmet 
Published: October 2023

AbstractIn recent years, the widespread utilization of biological data processing technology has been driven by its cost-effectiveness. Consequently, next-generation sequencing (NGS) has become an integral component of biological research. NGS technologies enable the sequencing of billions of nucleotides in the entire genome, transcriptome, or specific target regions. This sequencing generates vast data matrices. Consequently, there is a growing demand for deep learning (DL) approaches, which employ multilayer artificial neural networks and systems capable of extracting meaningful information from these extensive data structures. In this study, the aim was to obtain optimized parameters and assess the prediction performance of deep learning and machine learning (ML) algorithms for binary classification in real and simulated whole genome data using a cloud-based system. The ART-simulated data and paired-end NGS (whole genome) data of Ch22, which includes ethnicity information, were evaluated using XGBoost, LightGBM, and DL algorithms. When the learning rate was set to 0.01 and 0.001, and the epoch values were updated to 500, 1000, and 2000 in the deep learning model for the ART simulated dataset, the median accuracy values of the ART models were as follows: 0.6320, 0.6800, and 0.7340 for epoch 0.01; and 0.6920, 0.7220, and 0.8020 for epoch 0.001, respectively. In comparison, the median accuracy values of the XGBoost and LightGBM models were 0.6990 and 0.6250 respectively. When the same process is repeated for Chr 22, the results are as follows: the median accuracy values of the DL models were 0.5290, 0.5420 and 0.5820 for epoch 0.01; and 0.5510, 0.5830 and 0.6040 for epoch 0.001, respectively. Additionally, the median accuracy values of the XGBoost and LightGBM models were 0.5760 and 0.5250, respectively. While the best classification estimates were obtained at 2000 epochs and a learning rate (LR) value of 0.001 for both real and simulated data, the XGBoost algorithm showed higher performance when the epoch value was 500 and the LR was 0.01. When dealing with class imbalance, the DL algorithm yielded similar and high Recall and Precision values. Conclusively, this study serves as a timely resource for genomic scientists, providing guidance on why, when, and how to effectively utilize deep learning/machine learning methods for the analysis of human genomic data.
Neurocognitive skills and vulnerability for psychosis in depression and across the psychotic spectrum: findings from the PRONIA Consortium
Authors: Bonivento Carolina , Kambeitz-Ilankovic Lana , Maggioni Eleonora , Borgwardt Stefan , Lencer Rebekka , Meisenzahl Eva , Kambeitz Joseph , Ruhrmann Stephan , Salokangas Raimo K. R. , Bertolino Alessandro , Stainton Alexandra , Wenzel Julian , Pantelis Christos , Wood Stephen J. , Upthegrove Rachel , Koutsouleris Nikolaos , Brambilla Paolo ,   the PRONIA Consortium
Published: October 2023

BackgroundNeurocognitive deficits are a core feature of psychosis and depression. Despite commonalities in cognitive alterations, it remains unclear if and how the cognitive deficits in patients at clinical high risk for psychosis (CHR) and those with recent-onset psychosis (ROP) are distinct from those seen in recent-onset depression (ROD).AimsThis study was carried out within the European project ‘Personalized Prognostic Tools for Early Psychosis Management’, and aimed to characterise the cognitive profiles of patients with psychosis or depression.MethodWe examined cognitive profiles for patients with ROP (n = 105), patients with ROD (n = 123), patients at CHR (n = 116) and healthy controls (n = 372) across seven sites in five European countries. Confirmatory factor analysis identified four cognitive factors independent of gender, education and site: speed of processing, attention and working memory, verbal learning and spatial learning.ResultsPatients with ROP performed worse than healthy controls in all four domains (P < 0.001), whereas performance of patients with ROD was not affected (P > 0.05). Patients at CHR performed worse than healthy controls in speed of processing (P = 0.001) and spatial learning (P = 0.003), but better than patients with ROP across all cognitive domains (all P ≤ 0.01). CHR and ROD groups did not significantly differ in any cognitive domain. These findings were independent of comorbid depressive symptoms, substance consumption and illness duration.ConclusionsThese results show that neurocognitive abilities are affected in CHR and ROP, whereas ROD seems spared. Although our findings may support the notion that those at CHR have a specific vulnerability to psychosis, future studies investigating broader transdiagnostic risk cohorts in longitudinal designs are needed.
Exercise Interventions for Prostate Cancer Survivors Receiving Hormone Therapy: Systematic Review
Authors: Moe Esther L. , Chadd Joanna , McDonagh Marian , Valtonen Maarit , Horner-Johnson Willi , Eden Karen B. , Guise Jeanne-Marie , Nail Lillian , Winters-Stone Kerri M. 
Published: October 2023

ABSTRACT
Prostate cancer survivors (PCS) receiving androgen deprivation therapy (ADT) often experience adverse effects that negatively affect physical function and quality of life. Exercise may ameliorate those treatment adverse effects, and effective, scalable interventions to increase exercise behaviors are needed. The objective of our review is to evaluate both the efficacy and the implementation methods of exercise interventions for PCS receiving ADT. We searched MEDLINE®, PsycINFO, and the Cochrane Central Register of Controlled Trials through May 2016. Randomized controlled trials of exercise intervention PCS receiving ADT were included. The protocol was registered with PROSPERO (#CRD42015017348). Two authors independently reviewed articles for inclusion and risk of bias. Nine articles describing eight randomized controlled trials were included. The included interventions varied in training type (resistance or aerobic), length of intervention, dose of training (number of exercise sessions per week), and whether training was supervised or unsupervised. Despite heterogeneous interventions, varied measures, and generally short duration of training (average of 12 wk), improvements in fitness, symptoms, physical function, and quality of life were reported. The exercise training sessions were well attended, because few participants discontinued their participation in the exercise interventions, and attendance at supervised exercise sessions ranged from 74% to 94%. Self-reported compliance with the unsupervised exercise component was lower than that with the supervised sessions for trials that reported these data. In conclusion, supervised programs may be less scalable or accessible to populations with limited access. Future efforts should focus on delivery of programs that can adequately scale and contain the features of successful supervised interventions so that broad uptake by PCS on ADT can be achieved.
Evaluation of an enhanced service for medication review with follow up in Swiss community pharmacies: Pre-post study protocol
Authors: Amador-Fernández Noelia , Escaith Mathilde , Simi Elodie , Quintana-Bárcena Patricia , Berger Jérôme 
Published: October 2023

Background
In Switzerland, 20,000 people are hospitalized each year as result of drug related problems (DRPs). The sources of DRPs can be related to patients’ behavior (i.e., wrong administration) or to health processes (i.e., drug-drug interaction). No community pharmacy (CP) service focus on DRPs related to patients’ behavior is currently recognized or remunerated in Switzerland. A medication review with follow up (MRF) has been developed to evaluate prescription and non-prescription medication.

Objective
To evaluate the impact of MRF service for the identification and management DRPs associated to patients’ behavior and to describe pharmaceutical interventions carried out through MRF.

Methods
A pre-post intervention study with a cluster design and one intervention group will be carried out in CPs in the canton of Vaud (Switzerland) for 15 months. Volunteer pharmacists will be trained on the identification and management of DRPs related to patients’ behavior. After training, they will include randomly selected adults taking four or more chronic drugs prescribed for at least three months prior to recruitment. Then, they will conduct three pharmacist-patient face-to-face consultations at 6-month intervals. Tasks will be differentiated by pharmacy technician or pharmacist to triage expired medication or to manage DRPs in a structured manner, respectively. The primary outcome is the identification of DRPs associated to patients’ behavior. Secondary outcomes are to assess patients’ medication knowledge, number of expired medications, interventions carried out by pharmacists and pharmacists’ satisfaction. The study will begin in April 2023 in 19 to 35 pharmacies that will recruit at least 162 patients. A sub analysis will be carried out for patients with 65 years old or over.

Conclusions
The MRF intervention features a training designed for an enhanced evaluation of patient’s behavior towards their medication. The study will allow the assessment and management of DRPs in Swiss CPs with the support of the local health authorities and pharmacist association.

Trial registration
Clinicaltrials.gov NCT05348538.
Projective self-dual polygons in higher dimensions
Authors: Chavez-Caliz Ana 
Published: October 2023

Abstract
This paper examines the moduli space M
m

,n,k
of m-self-dual n-gons in ℙ
k
. We present an explicit construction of self-dual polygons and determine the dimension of M
m

,n,k
for certain n and m. Additionally, we propose a conjecture that extends Clebsch’s theorem, which states that every pentagon in ℝℙ2 is invariant under the Pentagram map.
How did Laotse Transform Heidegger: The Generation of a New Philosophical Grammar
Authors: Xia Kejun 
Published: October 2023

Abstract
The relationship between Heidegger and Chinese Taoism has long been ambigious, and the recent publication of Heidegger’s Black Notebooks (GA97-102) will help us to find the answer. From the co-translations of the Tao Te Ching by Heidegger and Paul Shih-yi Hsiao in the Black Notebooks, it is clear that Heidegger’s expressions and ideas were transformed by Tao Te Ching. This paper attempts to point out the documentary evidence of the relevant influence and to indicate how the language of Heidegger’s thought was completely transformed by the Daoist dialectic in a purely philosophical syntactic logic. It will further show the future intellectual value of this transformation.
The first record of partial xanthochromism in big-eared opossum, Didelphis aurita (Didelphimorphia, Didelphidae)
Authors: Cotts Leonardo , Prestes Stella Barbara Serodio , Pires Jeferson Rocha , Mathias Maria da Luz 
Published: October 2023

Abstract

Didelphis aurita is an abundant South American didelphid. Chromatic disorders are rare and scarcely known in marsupials. We report and describe the occurrence of xanthochromism (yellowish coloration) in D. aurita, being the first record of this anomaly for opossums. The emergence of the xanthochromism correlated with the anthropogenic stress in urban-sylvatic interface suggests that chromatic disorders may serve as useful bioindicators of the health of wildlife in disturbed environments.
Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
Authors: Stojic Vladislava , Zdravkovic Natasa , Nikolic-Turnic Tamara , Zdravkovic Nebojsa , Dimitrijevic Jelena , Misic Aleksandra , Jovanovic Kristijan , Milojevic Stefan , Zivic Jelena 
Published: October 2023

Abstract
The aim of this study was to evaluate the efficacy of endoscopic polypectomy as a therapeutic treatment for malignant alteration of colorectal polyps. In a 5-year research, 89 patients were included, who were tested and treated at the University Clinical Center Kragujevac, Kragujevac, Serbia, with the confirmed presence of malignant alteration polyps of the colon by colonoscopy, which were removed using the method of endoscopic polypectomy and confirmed by the histopathological examination of the entire polyp. After that, the same group of patients was monitored endoscopically within a certain period, controlling polypectomy locations and the occurrence of a possible remnant of the polyp, in the period of up to 2 years of polypectomy. We observed that, with an increasing size of polyps, there is also an increase in the percentage of the complexity of endoscopic resection and the appearance of remnant with histological characteristics of the invasive cancer. The highest percentage of incomplete endoscopic resection and the appearance of remnant with histological characteristics of the invasive cancer were shown at malignant altered polyps in the field of tubulovillous adenoma. Eighteen patients in total underwent the surgical intervention. In conclusion, our data support the high efficacy of endoscopic polypectomy for the removal of the altered malignant polyp.
Laser re-melting of modified multimodal Cr3C2–NiCr coatings by HVOF: Effect on the microstructure and anticorrosion properties
Authors: Irfan  , Hu Ming , Meng Lingyu , Shi Chenxi 
Published: October 2023

Abstract
Modified multimodal (MMP) Cr3C2–NiCr coatings were fabricated by high-velocity oxy-fuel (HVOF) spraying deposited on a CuCrZr alloy substrate. However, due to the lack of its inevitable porosity, an additional laser re-melting (LRM) approach is highly required to improve the coating performance. Therefore, the LRM technique is employed in this study to improve the microstructure properties of an MMP Cr3C2–NiCr coating by HVOF. Solid-state phase transformation from Cr3C2 to Cr7C3 occurred during the LRM process. After the LRM process, the coating exhibits the presence of Cr3C2 nanoparticles that serve as reinforcement. These nanoparticles demonstrate minimal lattice misfit and exhibit high stability throughout the LRM process. The surface of the coating undergoes modification, resulting in the formation of homogeneous nano (20–130 nm), micron (150 nm to 0.3 μm), and submicron (2–3 μm) Cr3C2 structures, along with high-density microstructures, after the LRM process. Nano-Cr3C2 particle reinforced with high total work function and incredibly increased corrosion rate significantly improves coating corrosion resistance. Overall, porosity decreased from 3.9% of the HVOF coating to 0.3% of the LRM. As a result, the current density of anticorrosion decreased from 33.7 to 4.35 µA·cm−2, and the Vickers microhardness average values ranged from 1,050 to 1,300 HV0.3, indicating improved microstructure development and related properties.
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation
Authors: Speir Mary , Tye Hazel , Gottschalk Timothy A , Simpson Daniel S , Djajawi Tirta M , Deo Pankaj , Ambrose Rebecca L , Conos Stephanie A , Emery Jack , Abraham Gilu , Pascoe Ashlyn , Hughes Sebastian A , Weir Ashley , Hawkins Edwin D , Kong Isabella , Herold Marco J , Pearson Jaclyn S , Lalaoui Najoua , Naderer Thomas , Vince James E , Lawlor Kate E 
Published: October 2023

AbstractProgrammed cell death pathways play an important role in innate immune responses to infection. Activation of intrinsic apoptosis promotes infected cell clearance; however, comparatively little is known about how this mode of cell death is regulated during infections and whether it can induce inflammation. Here, we identify that the pro‐survival BCL‐2 family member, A1, controls activation of the essential intrinsic apoptotic effectors BAX/BAK in macrophages and monocytes following bacterial lipopolysaccharide (LPS) sensing. We show that, due to its tight transcriptional and post‐translational regulation, A1 acts as a molecular rheostat to regulate BAX/BAK‐dependent apoptosis and the subsequent NLRP3 inflammasome‐dependent and inflammasome‐independent maturation of the inflammatory cytokine IL‐1β. Furthermore, induction of A1 expression in inflammatory monocytes limits cell death modalities and IL‐1β activation triggered by Neisseria gonorrhoeae‐derived outer membrane vesicles (NOMVs). Consequently, A1‐deficient mice exhibit heightened IL‐1β production in response to NOMV injection. These findings reveal that bacteria can induce A1 expression to delay myeloid cell death and inflammatory responses, which has implications for the development of host‐directed antimicrobial therapeutics.
Uso de endoprótesis para el tratamiento de enfermedades no neoplásicas de la rodilla
Authors: Jorge Fernando Daniel , Varaona José María , Prado Lionel , Tálamo Francisco , Pérez Cortés Pablo 
Published: October 2023

Introducción: Las endoprótesis son el método de elección para la reconstrucción luego de las resecciones oncológicas. Los avances en los materiales y diseños permitieron expandir las indicaciones a enfermedades no neoplásicas. Su montaje intraoperatorio simple y rápido, y su estabilidad mecánica inmediata permiten una rehabilitación y una recuperación funcional tempranas. Sin embargo, la tasa de fallas es elevada, aunque distinta de la de las enfermedades oncológicas. Las causas predominantes son diferentes. Objetivos: Analizar nuestra experiencia con el uso de endoprótesis de rodilla y compararla con los estudios publicados,evaluando los resultados funcional y radiográfico, la supervivencia del implante y las causas de su eventual falla. Materiales y Métodos: Se seleccionaron pacientes con enfermedad no neoplásica compleja de rodilla que requirieran una reconstrucción con endoprótesis. Para el examen clínico y la evaluación funcional se utilizó el puntaje de la Musculoskeletal Tumor Society, y para las fallas de los implantes, la clasificación de Henderson y cols. modificada. Resultados: Se estudiaron 12 endoprótesis, con un seguimiento promedio de 3.8 años. Se registraron 2 fallas (18%), con un tiempo promedio hasta la falla de 47.5 meses. Una fue tipo 2 (aflojamiento aséptico) y la otra, tipo 4 (infección). No hubo otras complicaciones. En la evaluación funcional, el puntaje final medio fue del 76,6%. Conclusión: Nuestros resultados respaldan el uso de endoprótesis para enfermedades complejas no neoplásicas de rodilla en pacientes cuidadosamente seleccionados, pese a ser un procedimiento quirúrgico complejo y con muchas complicaciones.