bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comunicación educativa y COVID-19. Desafíos de la pospandemia
Authors: Percastre-Mendizábal Salvador 
Published: February 2024

Internet, sus plataformas o medios sociales, sus redes digitales y los diversos dispositivos asociados a la navegación ciberespacial cobraron una formidable relevancia durante la pandemia del COVID-19 en tanto que representaron el papel crucial en la comunicación educativa de estudiantes de todos los niveles, en todos los centros educativos al rededor del mundo. Este rol educativo digital, de diversas maneras inédito por su amplitud y cobertura, se constituyó en el único recurso para conectar a las y los alumnos con las escuelas y sus profesores, desplazando los intrincados procesos de enseñanza-aprendizaje al ámbito digital, en lo que se popularizó como educación virtual o educación en línea.
Activation of Stimulator of Interferon Genes (STING): Promising Strategy to Overcome Immune Resistance in Prostate Cancer
Authors: Alnukhali Mohammed , Altabbakh Omar , Farooqi Ammad Ahmad , Pollack Alan , Daunert Sylvia , Deo Sapna , Tao Wensi 
Published: February 2024

:
Prostate cancer (PCa) is the most frequent and second-lethal cancer among
men. Despite considerable efforts to explore treatments like autologous cellular immunotherapy
and immune checkpoint inhibitors, their success remains limited. The intricate
tumor microenvironment (TME) and its interaction with the immune system pose
significant challenges in PCa treatment. Consequently, researchers have directed their focus
on augmenting the immune system's anti-tumor response by targeting the STimulator
of the Interferon Genes (STING) pathway. The STING pathway is activated when
foreign DNA is detected in the cytoplasm of innate immune cells, resulting in the activation
of endoplasmic reticulum (ER) STING. This, in turn, triggers an augmentation of
signaling, leading to the production of type I interferon (IFN) and other pro-inflammatory
cytokines. Numerous studies have demonstrated that activation of the STING pathway
induces immune system rejection and targeted elimination of PCa cells. Researchers
have been exploring various methods to activate the STING pathway, including the
use of bacterial vectors to deliver STING agonists and the combination of radiation therapy
with STING agonists. Achieving effective radiation therapy with minimal side effects
and optimal anti-tumor immune responses necessitates precise adjustments to radiation
dosing and fractionation schedules. This comprehensive review discusses promising
findings from studies focusing on activating the STING pathway to combat PCa. The
STING pathway exhibits the potential to serve as an effective treatment modality for
PCa, offering new hope for improving the lives of those affected by this devastating disease.
Biogenesis and Function of circRNAs in Pulmonary Fibrosis
Authors: Zhang Songzi , Hu Wenjie , Lv Changjun , Song Xiaodong 
Published: February 2024

Abstract:
Pulmonary fibrosis is a class of fibrosing interstitial lung diseases caused by many
pathogenic factors inside and outside the lung, with unknown mechanisms and without effective
treatment. Therefore, a comprehensive understanding of the molecular mechanism implicated in
pulmonary fibrosis pathogenesis is urgently needed to develop new and effective measures. Although
circRNAs have been widely acknowledged as new contributors to the occurrence and development
of diseases, only a small number of circRNAs have been functionally characterized in
pulmonary fibrosis. Here, we systematically review the biogenesis and functions of circRNAs and
focus on how circRNAs participate in pulmonary fibrogenesis by influencing various cell fates.
Meanwhile, we analyze the current exploration of circRNAs as a diagnostic biomarker, vaccine,
and therapeutic target in pulmonary fibrosis and objectively discuss the challenges of circRNA-
based therapy for pulmonary fibrosis. We hope that the review of the implication of circRNAs
will provide new insights into the development circRNA-based approaches to treat pulmonary
fibrosis.
Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, thereby Promoting Angiogenesis in Hepatocellular Carcinoma
Authors: Zhang Fabiao , Wang Binfeng , Zhang Wenlong , Xu Yongfu , Zhang Caiming , Xue Xiangyang 
Published: February 2024

Background:
Hepatocellular carcinoma (HCC) is characterized by high vascularity and
notable abnormality of blood vessels, where angiogenesis is a key process in tumorigenesis and
metastasis. The main functions of Nei Like DNA Glycosylase 3 (NEIL3) include DNA alcoholization
repair, immune response regulation, nervous system development and function, and DNA damage
signal transduction. However, the underlying mechanism of high expression NEIL3 in the
development and progression of HCC and whether the absence or silencing of NEIL3 inhibits the
development of cancer remain unclear. Therefore, a deeper understanding of the mechanisms by
which increased NEIL3 expression promotes cancer development is needed.

Methods:
Expression of NEIL3 and its upstream transcription factor MAZ in HCC tumor tissues
was analyzed in bioinformatics efforts, while validation was done by qRT-PCR and western blot
in HCC cell lines. The migration and tube formation capacity of HUVEC cells were analyzed by
Transwell and tube formation assays. Glycolytic capacity was analyzed by extracellular acidification
rate, glucose uptake, and lactate production levels. Chromatin immunoprecipitation (ChIP)
and dual-luciferase reporter gene assays were utilized to investigate specific interactions between
MAZ and NEIL3.

Results:
NEIL3 and MAZ were substantially upregulated in HCC tissues and cells. NEIL3 was involved
in modulating the glycolysis pathway, suppression of which reversed the stimulative impact
of NEIL3 overexpression on migration and angiogenesis in HUVEC cells. MAZ bound to the
promoter of NEIL3 to facilitate NEIL3 transcription. Silencing MAZ reduced NEIL3 expression
and suppressed the glycolysis pathway, HUVEC cell migration, and angiogenesis.

Conclusion:
MAZ potentiated the upregulated NEIL3-mediated glycolysis pathway and HCC angiogenesis.
This study provided a rationale for the MAZ/NEIL3/glycolysis pathway as a possible
option for anti-angiogenesis therapy in HCC.
Assessing the Impact of Stem Cell-based Therapy on Periodontal Health:
A Meta-analysis of Clinical Studies
Authors: Shao Yu-Han , Song Yi , Feng Qiao-Li , Deng Yan , Tang Tao 
Published: February 2024

Objective::
While clinical trials exploring stem cells for regenerating periodontal tissues
have demonstrated positive results, there is a limited availability of systematic literature reviews on
this subject. To gain a more comprehensive understanding of stem cell interventions in periodontal
regeneration, this meta-analysis is undertaken to assess the beneficial effects of stem cells in human
periodontal regeneration.

Methods::
"PubMed," "Cochrane Library," "Web of Science," "Embase," "Wanfang," and "CNKI,"
were used to extract clinical studies related to the utilization of stem cells in repairing periodontal
tissue defects. This search included studies published up until October 5, 2023. The inclusion criteria
required the studies to compare the efficacy of stem cell-based therapy with stem cell-free therapy
for regenerating periodontal tissues. Meta-analysis was conducted using Review Manager software
(version 5.4).

Results::
This meta-analysis synthesized findings from 15 selected studies investigating the impact of
stem cell interventions on periodontal tissue regeneration. The "stem cell" group displayed a substantial
reduction in clinical attachment level (CAL) compared to the "control" group within 3 to 12
months post-surgery. However, no significant differences in CAL gain were found between groups.
Probing pocket depth (PPD) significantly decreased in the "stem cell" group compared to the "control"
group, particularly for follow-up periods exceeding 6 months, and dental stem cell treatment
exhibited notable improvements. Conversely, no significant differences were observed in PPD reduction.
Gingival recession (GR) significantly decreased in the "stem cell" group compared to the "control"
group at 3 to 12 months post-surgery. No significant differences were observed in GR reduction
between groups. No significant differences were identified in cementoenamel junction-bone distance
reduction, infrabony defect reduction, or bone mineral density increase between the two groups.
Furthermore, no significant changes were observed in the gingival index, plaque index, or width of
keratinized gingiva.

Conclusion::
In conclusion, while stem cell-based therapy offers promising prospects for periodontal
defect treatment, there are notable limitations in the current body of research. Larger, multicenter,
double-blind RCTs with robust methodologies are needed to provide more reliable evidence for stem
cell-based intervention in periodontitis.
Use of Video in Telephone Triage in Out-of-Hours Primary Care: Register-Based Study
Authors: Nebsbjerg Mette Amalie , Vestergaard Claus Høstrup , Bomholt Katrine Bjørnshave , Christensen Morten Bondo , Huibers Linda 
Published: February 2024

Abstract

Background
Out-of-hours primary care (OOH-PC) is challenging due to high workloads, workforce shortages, and long waiting and transportation times for patients. Use of video enables triage professionals to visually assess patients, potentially ending more contacts in a telephone triage contact instead of referring patients to more resource-demanding clinic consultations or home visits. Thus, video use may help reduce use of health care resources in OOH-PC.

Objective
This study aimed to investigate video use in telephone triage contacts to OOH-PC in Denmark by studying rate of use and potential associations between video use and patient- and contact-related characteristics and between video use and triage outcomes and follow-up contacts. We hypothesized that video use could serve to reduce use of health care resources in OOH-PC.

Methods
This register-based study included all telephone triage contacts to OOH-PC in 4 of the 5 Danish regions from March 15, 2020, to December 1, 2021. We linked data from the OOH-PC electronic registration systems to national registers and identified telephone triage contacts with video use (video contact) and without video use (telephone contact). Calculating crude incidence rate ratios and adjusted incidence rate ratios (aIRRs), we investigated the association between patient- and contact-related characteristics and video contacts and measured the frequency of different triage outcomes and follow-up contacts after video contact compared to telephone contact.

Results
Of 2,900,566 identified telephone triage contacts to OOH-PC, 9.5% (n=275,203) were conducted as video contacts. The frequency of video contact was unevenly distributed across patient- and contact-related characteristics; it was used more often for employed young patients without comorbidities who contacted OOH-PC more than 4 hours before the opening hours of daytime general practice. Compared to telephone contacts, notably more video contacts ended with advice and self-care (aIRR 1.21, 95% CI 1.21-1.21) and no follow-up contact (aIRR 1.08, 95% CI 1.08-1.09).

Conclusions
This study supports our hypothesis that video contacts could reduce use of health care resources in OOH-PC. Video use lowered the frequency of referrals to a clinic consultation or a home visit and also lowered the frequency of follow-up contacts. However, the results could be biased due to confounding by indication, reflecting that triage GPs use video for a specific set of reasons for encounters.
Rethinking the international competitiveness of olive oil in Spain and Chile: governance of sustainable practices
Authors: Boza Sofía , Núñez-Mejía Aracely , Mora Marcos 
Published: February 2024

Abstract
The international competitiveness of agri-food products is crucial for the economic growth of exporting countries, which is also closely related to critical aspects of sustainable development. This research aims to comprehensively understand the factors of international competitiveness in two contrasting cases: Spain as the world’s leading exporter and Chile as an emerging exporter of olive oil. This study takes a novel approach by including the governance of sustainable practices as part of the framework for analyzing international competitiveness. A mixed research method was used: firstly, quantitative indicators were estimated to compare the levels of international competitiveness of both countries; secondly, a qualitative analysis was carried out to analyze in depth the determinants of international competitiveness based on Porter’s Diamond Model. The results show that Spain has solidified its position as the world’s leading olive oil exporter. On the other hand, Chile still has a small market share; however, it already achieved its revealed comparative advantage in 2015. The potential causes of this performance were determined by the comparative study of the determinants of the competitiveness of Porter’s diamond model; “Factor conditions”, “Demand conditions”, “Firm strategy, structure, and rivalry”, “Related and supporting industries”, “Government” and “Chance”. In addition, both countries show the adoption of sustainable practices in their exports driven by subsidy policies, informal conventions, and consumer preferences. Finally, some relevant implications for management and public policy are highlighted.
Transparent AI in Auditing through Explainable AI
Authors: Zhong Chen , Goel Sunita 
Published: February 2024

SUMMARY
The scope and complexity of artificial intelligence (AI) applications in auditing have grown beyond automating tasks to performing decision-making tasks. Consequently, understanding how AI-based models arrive at their decisions has become crucial, particularly for auditing tasks that demand greater accountability and that involve complex decision-making processes. In this paper, we explore the implementation of explainable AI (XAI) through a fraud detection use case and demonstrate how integrating an explainability layer using XAI can improve the interpretability of AI models, enabling stakeholders to understand the models’ decision-making process. We also present emerging AI regulations in this context.
Analysis of Calcium and Phosphate Ion Extraction From Dental Enamel by Bleaching Gels Using Ion Chromatography, Micro-CT, and SEM
Authors: de Mendonça LC , Rodrigues MdeLA , Bicalho AA , da Silva GR , Quagliatto PS , Santos DQ , Soares CJ 
Published: February 2024

SUMMARY

Objectives
To evaluate the volume and depth of enamel loss promoted by 37.5% and 7.5% hydrogen peroxide (HP) gels, and quantify the loss of calcium (Ca) and phosphate (P) ions by using ion chromatography (IC) analysis after bleaching.

Methods
Sixty bovine enamel specimens were randomly divided into three groups: Control – no bleaching gel; HP37.5%, application of HP 37.5% for 45 minutes for 14 days; and HP7.5%, application of HP 7.5% for 3 applications of 8 minutes. The surface analysis (n=5) was performed using a scanning electron microscope (SEM) and dispersive energy system (EDS) to calcium and phosphorus dosage. The micro-CT was used for the enamel loss analysis (n=5). IC was used to analyze extracted Ca and P (n=10). Data were analyzed by one-way ANOVA and two-way repeated measures ANOVA, followed by Tukey and Dunnett’s tests (α=0.05).

Results
Significantly higher volume and depth of enamel loss were found for bleached groups compared with the control group. HP7.5% had significantly higher enamel change than HP37.5%. SEM showed higher enamel porosity for HP37.5% and HP7.5% compared to control. The IC demonstrated a significant increase of Ca incorporated into the gel, however, only HP7.5% had a higher P presence than the control group. The HP7.5% showed higher Ca and P ion exchange than HP37.5% (p&lt;0.001).

Conclusion
HP37.5% and HP7.5%, caused enamel mineral changes compared with the control group. The IC method was demonstrated to be an effective methodology for detecting enamel mineral loss by the bleaching gel.
Polychromatic Restoration of Anterior Fractured Teeth Using a Custom-made Silicone Matrix
Authors: Furuse AY , Quiroz-Zubizarreta EM , dos Santos FFV 
Published: February 2024

SUMMARY
When restoring anterior teeth using resin composites, the use of silicone guide matrices obtained from diagnostic wax-ups is recommended, as this technique facilitates layering and optimizes working time. This is particularly important in polychromatic layering and when more than one anterior tooth is to be restored with resin composites. However, in cases of fractured anterior teeth, it is often not feasible to perform a previous impression and waxing. In these cases, due to trauma and related psychological aspects, patients usually seek immediate esthetic solutions. Therefore, an interesting restorative approach that can simplify the restorative technique is the creation of a silicone guide matrix obtained from the patient’s fractured tooth, without the need for prior waxing. This type of personalized matrix was initially proposed by Bertholdo, Ricci, and Barrote. Thus, the purpose of the present work is to demonstrate a modification of the technique for making this type of custom-made matrix for the restoration of two upper central incisors of a 14-year-old patient who fractured his teeth in a bicycle accident.
Green Marketing and Greenwashing in Poland and France, a Comparison of Consumer Reactions
Authors: Kowalik Izabela , Leyge Marine , Sikora Tomasz 
Published: February 2024

Abstract

Purpose
The human influence on the environment and its protection are subjects of marketing communication, and numerous regulations were issued to control the “green” messages. The popularity of such practices makes it essential to compare the reactions to green marketing and greenwashing in two European societies and to check how “green” awareness of European consumers translates into behavior.

Design/method/approach
The review of literature and decisions regulating green marketing is followed by a CAWI study of the French and Polish young consumers ecological attitudes, intentions, and behaviors. ANOVA and linear regression methods were used to analyze data.

Findings
The French young consumers are more pro-environmentally focused than Poles and display more robust skepticism toward sustainable claims. The Poles, more than the French, focus on the products' primary functions. Both groups show higher levels of spontaneous awareness of greenwashing than average consumers in those two countries. Our hypotheses about relationships of ecological attitudes with purchase intentions and behavior were supported. Surprisingly, there was a negative relation between French nationality and environmental behaviors.

Originality/Value
There is a regional market segment of European consumers from Generation Z who react similarly to green marketing claims and reject the greenwashing actions. They are highly environmentally aware, but the relationships between their eco-attitudes and behaviors, albeit significant, are weak.

Practical implications
The marketers aiming their activity at the young customer segment should not expect an immediate influence of ecological attitudes on behaviors. This market segment can instead become a powerful influencing group among their societies.
How general is managerial human capital?: Evidence from the Retention of Managers after M&As
Authors: Hirata Kenjiro , Suzuki Ayako , Takii Katsuya 
Published: February 2024

Abstract
This paper investigates the transferability of managerial human capital by examining how managers’ tenures in target firms influence their probability of retention as board members after mergers or acquisitions in Japanese firms. It develops a general equilibrium model that distinguishes several hypotheses on managerial human capital based on the coefficients of tenure on separation, given several data limitations. In particular, the paper provides a novel method to correct for selection biases by utilizing the timing of selection in a selected sample, which does not require a random sample from the population. Our results suggest that Japanese firms value both target firm-specific and general human capital after M&As and that experience as an employee increases firm-specific skills, but at the expense of the accumulation of general skills. However, managerial experience does not have this effect.
Harnessing XPM effects in non-linear directional couplers for 4-bit gray code conversion and even parity verification
Authors: Yadav Ajay , Kumar Ajay , Prakash Amit 
Published: February 2024

Abstract
The all-optical switching phenomena in the non-linear directional coupler using cross-phase modulation (XPM) effect have been proposed. It is designed to generate an all-optical XOR functionality, considering the XOR logic gates as a basic module the design and analysis of an efficient all-optical 4-bit binary to gray code converter and 4-bit even parity checker circuit is proposed. The design methodology includes the switching of a weak continuous-wave (CW) signal, which is controlled by the combination of two controlled pump signals. In this paper, mathematical analysis of the coupled mode theory associated with optical directional couplers has been discussed. The switching characteristics of XPM effect based All-optical directional couplers have been examined for appropriate values of the controlled pump signals. Appropriate values of extinction ratio and corresponding controlled pump signal levels are investigated for an efficient generation of XOR logic gates. Further, the detailed analysis of layout generation and design aspects of All-optical 4-bit binary to gray code converter and 4-bit even parity checker circuits have been carried out. The proposed methodology is verified by the appropriate simulation results, which include the transmittivity, extinction ratio (Xratio) curve variation and dynamic time domain plot associated with proposed units.
Preparation of laser induced periodic surface structures for gas sensing thin films and gas sensing verification of a NiO based sensor structure
Authors: Hotovy Ivan , Zehetner Johann , Rehacek Vlastimil , Mikolasek Miroslav , Kostic Ivan , Serecunova Stanislava , Seyringer Dana , Dohnal Fadi 
Published: February 2024

Abstract
This study presents different approaches to increase the sensing area of NiO based semiconducting metal oxide gas sensors. Micro- and nanopatterned laser induced periodic surface structures (LIPSS) are generated on silicon and Si/SiO2 substrates. The surface morphologies of the fabricated samples are examined by FE SEM. We select the silicon samples with an intermediate Si3N4 layer due to its superior isolation quality over the thermal oxide for evaluating the hydrogen and acetone sensitivity of a NiO based test sensor.
Linear block code with locality and availability inspired by tetrahedron
Authors: Farkaš Peter 
Published: February 2024

Abstract
The primary application of codes with locality and availability in distributed storage is for data recovery in case that data are lost on some damaged servers. Locality enables the recovery of lost data by contacting only a restricted number of remaining servers. Availability means that more than one subset of servers providing locality is available for data recovery for each server. The secondary application of these codes in distributed storage is to allow access to hot data in times of high demand. In this paper it is shown that the binary linear [14, 4, 7] code has locality 2 and availability 6 and it can be interpreted as a three-dimensional graph obtained from a [7, 3, 4] Simplex code. It is achieving upper bounds on basic parameters for codes with all-symbols locality and availability. This code can be a building element of more complex codes with scalability inspired by three-dimensional structures. The availability spectrum is introduced as a tool for analyzing codes with locality and availability.