bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference intervals and biological variation in parameters of the thrombin generation test in healthy individuals
Authors: Olga Melnichnikova , Yuliya Zhilenkova , Vitaly Lukinov , Ekaterina Zolotova , Konstantin Pishchulov , Svetlana Evgina , Maria Simakova , Tatyana Vavilova 
Published: November 2023

AbstractIntroductionEstablish the referenceintervals (RIs) and analyze biological variability (BV) to introduce the thrombin generation test (TGT) into clinical practice.MethodsTo determine the RIs parameters of TGT, we analyzed platelet‐poor plasma (PPP) (n = 123), rich (PRP) (n = 76), and microparticle‐mediated TGT (MP‐TGT) (n = 32) in healthy participants. For the BV study, we collected samples from five participants over 5 weeks. A nested analysis of variance (ANOVA) was performed to evaluate the BV results.ResultsThe between‐individual variation (CVG), within‐individual variation (CVI), analytical variation (CVA) for TGT on PPP for all parameters were from 5.5% to 17.3%, 5.4% to 17.7%, and 2.6% to 5.3%, respectively. For PRP, the CVG, CVI, and CVA were ranged from 3.0% to 23.7%, 8.4% to 23.0%, and 4.1% to 6.9%, respectively. The index of individuality (II) ranged from 0.3 to 3.1 for PPP and from 0.3 to 4.5 for PRP. The reference change value (RCV) for PPP was from 19.8% to 50.1%, while for PRP, it was 27.2% to 66.5%. We recommend using the RIs for the parameters ETP (nM/min): 1101.6–2332.1 and Peak (nM): 163.5–381.3 for PPP and ETP (nM/min): 1088.5–2634.9; Peak (nM): 72.6–210.7 for PRP. The resulting MP‐TGT are highly dependent on age require a larger sample.ConclusionFor TGT on PPP and PRP the RIs developed on our population for Peak and ETP parameters can be used. Time parameters: Lagtime and ttPeak, min with II < 0.6, require monitoring over time with RCV calculation.
A tactile approach to introduce the skin autoimmune disease psoriasis to the general public and the vision‐impaired community
Authors: Song Runqiu , Ye Jingran , Chung Shanzou , Meyer C Chris , Déchelette Corinne , Purcell Anthony W , Braun Asolina 
Published: November 2023

AbstractScientific outreach activities play an important role in disseminating knowledge, connecting the general public to research and breaking down scientific skepticism barriers. However, the vision‐impaired community is often disadvantaged when the most common audio–visual approach of scientific communication is applied. Here we integrated tactile clues in the scientific communication of immune processes involved in the autoimmune skin disease psoriasis. We fostered the involvement of the vision‐impaired community through interactive experiences, including tactile scientific origami art, a haptic poster and wood‐carved molecular models. Readily accessible science communication that engages a number of senses is a critical step toward making science more inclusive and engaging for individuals with a wide range of sensory abilities. The approach of the 2023 Monash Sensory Science exhibition aligns with the principles of equity, diversity and inclusion and helps to empower a more informed and scientifically literate public.
Effects of grit, calling, and resilience on the retention intention of general hospital nurses
Authors: Lee Gi Ran , Lee Imsun , Chung Mihee , Ha Jiyeon 
Published: November 2023

AbstractAimThis study aimed to determine the influence of personal factors such as grit, calling, and resilience on nurses’ retention intention in South Korean general hospitals.BackgroundThe global shortage and high turnover rate of nurses have become significant concerns with no clear solutions for increasing retention.IntroductionDetermining the factors related to the f general hospital nurses and retention intention is important for solving the problem of inadequate nursing personnel and improving the quality of nursing services.MethodsThis study was a descriptive survey of 221 nurses working at a general hospital in South Korea from July 2021 to February 2022. Data were collected using self‐reported online questionnaires, with measurement tools focusing on grit, calling, resilience, and retention intention. The STROBE checklist was used for reporting this study.ResultsThe average retention intention score was 5.35 ± 1.52 out of 8 points. Significant correlations were found between retention intention and grit, calling, and resilience. The factors influencing retention intention were job satisfaction, calling, marital status, and total career length, explaining 31.9% of the variance.ConclusionsTo enhance nurses’ intention to remain at general hospitals, their job satisfaction and sense of a calling should be improved. Further research should be conducted to identify factors that influence retention intention, particularly among groups with low job retention, with consideration of individual characteristics that might affect retention intention.Implications for nursing and health policyIncreasing nurses’ retention intention would alleviate the nursing shortage, help hospitals retain competent nurses, reduce turnover‐related costs, and improve organizational efficiency. Resolving the nursing shortage is critical for improving patient safety and nursing service quality at general hospitals.
Do the clinical practice guidelines for paediatric dentistry meet the quality standards? A meta‐research and quality appraisal using the AGREE II tool
Authors: Elagami Rokaia Ahmed , Laux Caroline Mariano , Gallegos Claudia López , Tedesco Tamara Kerber , Cóvos Thais Gimenez , Braga Mariana Minatel , Mendes Fausto Medeiros , Cenci Maximiliano Sérgio , Raggio Daniela Prócida 
Published: November 2023

AbstractBackgroundClinical practice guidelines (CPGs) enhance health care and aid clinicians' decisions.AimTo evaluate the quality of clinical guidelines in paediatric dentistry using the AGREE II tool.DesignPubMed, EMBASE, Scopus, LIVIVO, Lilacs, international guidelines websites, scientific societies, and gray literature were searched until September 2021. We included paediatric dental clinical guidelines and excluded drafts or guidelines for patients with special needs. Two independent reviewers performed quality assessment using the APPRAISAL OF GUIDELINES FOR RESEARCH & EVALUATION II (AGREE II) instrument. We calculated the mean overall domain scores (95% confidence interval) for each guideline. We used regression analysis to correlate the score of overall assessment and the six domains of AGREE II with guideline characteristics.ResultsForty‐four guidelines were included in this study. Highest mean score was for Domain 4 (Clarity of Presentation; 58%, 95% CI: 50.8–64.9), whereas the lowest was for Domain 5 (Applicability; 16%, 95% CI: 10.8–21.4). The reporting quality was improved in Domains 1–5 with reporting checklists (p < .001), whereas that of Domain 6 was improved by decreasing years since publication (p = .047).ConclusionPaediatric dental guidelines do not comply with the methodological quality standard, especially in Domain 5 (Applicability). The AGREE reporting checklist should be implemented with a system to evaluate the certainty of evidence for future guidelines.
Comparing the traditional and emerging therapies for enhancing wound healing in diabetic patients: A pivotal examination
Authors: Liao Chunfen , Zhu Mingjie , Ding Hongchen , Li Yanli , Sun Qianshu , Li Xueqin 
Published: November 2023

AbstractChronic non‐healing ulcers are common among diabetic patients, posing significant therapeutic challenges. This study compared traditional therapies (TT) and emerging therapies (ET) for enhancing diabetic patients' wound healing. A total of 150 diabetic patients with chronic ulcers, ages 30–65, were randomly assigned to one of two groups: TT (n = 75) or ET (n = 75). ET included growth factors, bioengineered skin substitutes, and hyperbaric oxygen therapy, while TT for wound healing predominantly included debridement, saline‐moistened dressings, and off‐loading techniques. The primary outcome was the percentage of lesions that healed within 12 weeks, which was assessed at intervals. Secondary outcomes included time to wound recovery, pain using Visual Analogue Scale (VAS), and life quality via Wound‐QoL questionnaire. By the 12th week, the ET group had a repair rate of 81.33% compared to 57.33% in TT group (p < 0.05). ET exhibited superior pain reduction (VAS score: 4.7 ± 1.6 for ET vs. 6.2 ± 1.4 for TT, p < 0.05) and improved life quality (Wound‐QoL score: 61.8 ± 9.1 for ET vs. 44.3 ± 10.3 for TT, p < 0.05). However, there were slightly more cases of cutaneous irritation and hematomas among ET patients. ET have demonstrated significant efficacy in accelerating wound healing in diabetic patients, surpassing traditional methods, with additional advantages in pain management and life quality. Due to the observed minor complications, however, caution is required.
Environmental conical nozzle levitator equipped with dual wavelength lasers
Authors: Thorpe Fox , Li Trevor , Weber Richard , McCormack Scott J. 
Published: November 2023

AbstractThe environmental conical nozzle levitator (E‐CNL) with dual‐wavelength lasers is an extreme environment materials characterization system that was designed to investigate ultra‐high‐temperature materials: refractory metals, oxides, carbides, and borides above 3000 K in a controlled atmosphere. This article details the characterizations using this system to establish its high‐temperature capabilities and to outline ongoing work on materials under extreme conditions. The system has been used to measure the melting point of several oxide materials (TiO2, Tm = 2091 ± 3 K; Al2O3, Tm = 2310 3 K; ZrO2, Tm = 2984 31 K; and HfO2, Tm = 3199 ± 45 K) and several air‐sensitive refractory metals (Ni, Tm = 1740 K; Ti, Tm = 1983 K; Nb, Tm = 2701 K; and Ta, Tm = 3368 K—note: mean ± standard deviation) during levitation which matched literature values within 0.17–2.43 % demonstrating high accuracy and precision. This containerless measurement approach is critical for probing properties without container‐derived contamination, and dual‐wavelength laser heating is essential to heat both relatively poor electrical conductors (some refractory metals and carbides) and insulators (oxides). The highest temperature achieved utilizing both lasers in these experiments was ∼4250 ± 34 K on a 76.6 mg, molten HfO2 sample using a normal spectral emissivity of 0.91. Stable levitation was demonstrated on spherical samples (yttria‐stabilized zirconia) while adjusting levitation gas composition from pure oxygen to pure argon, verifying atmospheric control up to 3173 K on solid or molten samples. These successes demonstrate the viability of in situ high‐temperature environmentally controlled studies potentially up to 4000 K on all classes of ultra‐high‐temperature materials in one system. These measurements highlight the E‐CNL system will be essential for the development of next‐generation ultra‐high‐temperature materials for hypersonic platforms, nuclear fission and fusion, and space exploration.
Developing a model of neonatal nurse‐controlled analgesia: A Delphi study
Authors: Muirhead Renee , Kynoch Kathryn , Peacock Ann , Birch Pita , Lewis Peter A. 
Published: November 2023

AbstractAimTo develop a nurse‐led model of analgesia to manage post‐operative pain in the surgical neonate.DesignA four‐round e‐Delphi study was conducted from March to December 2022.MethodsAn e‐Delphi method was used seeking a consensus of 70% or greater. Fifty‐one experts were invited to join the panel. Members consisted of multi‐disciplinary healthcare professionals who work in areas associated with neonatal care. In round 1, 49 statements relative to neonatal pain assessment and management were distributed to the panel. Panel members were asked to rate their level of agreeance on a Likert scale from 1 to 5 (1 = strongly disagree to 5 = strongly agree). Ratings equal to or greater than 4 represented agreement, 3 indicated uncertainty and 2 or less disagreement with the proposed statement. An opportunity for free‐text responses after each statement was provided. This iterative process continued for three rounds. In the fourth and final round, the completed model of neonatal nurse‐controlled analgesia was presented along with a further opportunity to provide feedback on the final version.ResultsFour rounds of statements and voting were required to reach consensus on a model of neonatal nurse‐controlled analgesia. The model consists of criteria for use, over‐arching guidelines and three separate pathways based on an individual baby's pain assessment scores, need for pain relieving interventions and time‐lapsed post‐surgical procedure.ConclusionA comprehensive model of neonatal nurse‐controlled analgesia, applicable to the Australasian context, was developed in collaboration with a group of neonatal experts.ImpactThis study provides a multi‐modal family‐integrated model to manage neonatal post‐operative pain. By providing nurses with increased autonomy to assess and manage acute pain, this model has the potential to not only provide a more responsive and individualized approach to alleviate discomfort, but highlights the integral role of parent partnerships in the neonatal intensive care.Reporting MethodThis study was reported in line with the Conducting and REporting of DElphi studies (CREDE) guidance on Delphi studies.Patient or Public ContributionNo patient or public contribution was utilized for this study.
Just keep swimming? Observations of resting behavior in gray reef sharks Carcharhinus amblyrhynchos (Bleeker, 1856)
Authors: Bullock Robert W. , Foster Craig , Lea James S. E. 
Published: November 2023

AbstractUnderstanding the respiratory modes of sharks has important implications for studying the metabolism, energetics, and behavioral strategies of different species. Here we provide the first reported observations of resting behavior in the gray reef shark Carcharhinus amblyrhynchos, a species typically considered an obligate ram ventilator. Observations were made at several locations in the Republic of Seychelles, where sharks were found resting under reef ledges and were unresponsive to the presence of divers. These findings update our understanding of the respiratory mode of this species and have implications for future research.
The physical and psychosocial impact of a school‐based running programme for adolescents with disabilities
Authors: Campagna J. , Czyszczon K. , Little J. , Selby C. , Wick L. , Ferreira D. , Oriel K. 
Published: November 2023

AbstractBackgroundAdolescents with disabilities have fewer opportunities to participate in community‐based fitness programmes. The purpose of this study was to examine the impact of a school‐based running programme at a local middle school in Lebanon, Pennsylvania, on fitness and quality of life (QoL) in children with physical and cognitive disabilities in a life‐skills classroom.MethodsNineteen adolescents with diagnosed disabilities including intellectual disability (ID), autism spectrum disorder and Down syndrome were recruited from three life‐skills classrooms to participate in a school‐based running programme. The programme was designed to be implemented two times/week for 6 weeks by classroom teachers/aides. Physical therapy faculty and students developed the programme and assisted with implementation. Each session lasted 30 min, consisting of a warm‐up and cooldown, relay races, games and timed runs. Pre‐ and post‐test measures included physiological cost index (PCI) and Paediatric Quality of Life Inventory™ (PedsQL™). Pre‐ and post‐test data were compared using Wilcoxon signed rank tests. Each week participants also completed a training log to reflect on the activity for the day.ResultsParticipants demonstrated significant improvements in PCI (P = 0.028) and the PedsQL™ (P = 0.008) following the running programme.ConclusionsResults of this study suggest that participation in a 6‐week school‐based running programme may improve fitness and QoL in adolescents with disabilities.
Midwifery Practice Leaders’ Experiences of Practice Changes Early in the COVID‐19 Pandemic: A Qualitative Exploration
Authors: Chapman Meredith , Evans Emily Cowley , Long Maryann H. 
Published: November 2023

IntroductionThe coronavirus disease 2019 (COVID‐19) pandemic generated considerable upheaval in all sectors of the US health care system, including maternity care. We focused this inquiry on midwifery practice leaders’ experiences and perspectives on changes that occurred in their practices early in the pandemic.MethodsThis was a qualitative descriptive study using thematic analysis. The data were responses to an open‐ended question in a survey of pandemic‐related employment and clinical practice changes. Findings are presented from a constructivist perspective, describing the experiences and perspectives of a group of US midwifery practice leaders during the initial phase of the COVID‐19 pandemic.ResultsTwo main themes emerged from the analysis: demands on midwives and driving forces. Demands on midwives were 3‐fold: clients’ needs, modification of care, and midwives’ needs. These encompassed the psychological, physical, and emotional toll that caring for women during the pandemic placed on midwives. Driving forces were those entities that spurred and directed change and included regulations, institutions, financial logistics, and team dynamics. Survey respondents in community (home and birth center) practices reported substantial increases in inquiries and client volume, and many respondents expressed concern about withdrawal of students from clinical placements.DiscussionMidwifery practices experienced profound changes in their work environments during the COVID‐19 pandemic, with both positive and negative characteristics. These challenges in providing birth care were similar to those reported in other countries. Results indicated existing guidance for maternity care during emergencies did not meet clients’ needs. Coordinated planning for maternity care in future prolonged health emergencies should incorporate best practices and include midwives in the process.
Innovation of the protocol for the application of cryolipolysis: Effects and mechanisms of action
Authors: Palauro Christiane Rodrigues Tofoli , Meyer Patrícia Froes , Soares Ciro Dantas , de Morais Carreiro Eneida , de Paiva Dumaresq Flávio , de Oliveira Fernando Cesar Camara , de Andrade Ana Laura Martins , da S P S Daumas Priscila 
Published: November 2023

AbstractBackgroundIn recent years, aesthetic procedures aiming at body remodeling and have grown exponentially. Cryolipolysis (CLL) has stood out as a noninvasive resource that acts directly on the subcutaneous adipose tissue promoting a significant reduction of adipose tissue through of cooling that could lead to the crystallization cytoplasmic lipids, loss of cellular integrity, apoptosis/necrosis of adipocytes, and local inflammation, producing selective loss of adipose tissue. Thus, the objective of the present study was to evaluate the effects of a specific technique of CLL application on the inflammatory reactions of the target tissue in different post‐application times.MethodsThis is a randomized, blind clinical study that evaluated the tissue sample of six patients after 45, 60, and 90 days of an innovative protocol for the application of CLL, with samples collected through abdominoplasty surgeries. The samples were evaluated by immunohistochemical analyses of several markers.ResultsA significantly greater increase in fibroblasts was observed at 45 days and greater phagocytic action at 60 days.Regarding the apoptosis process, the expression of caspase 3 and cleaved caspase 3 markers varied at different times, with cleaved caspase 3 being higher at 45 and 90 days after CLL application.ConclusionThe protocol of the CLL presented in this study was able to induce inflammatory responses in addition to confirming the selective apoptotic action at the different times studied.
Fox eyes lift—A new protocol for eyebrow elevation with laser Fotona
Authors: Burmann Tiana G. , Duarte Fernando B. , Akaishi Patrícia M. S. 
Published: November 2023

AbstractBackgroundThe eyelids play an important role in our appearance and are usually the first to show signs of age. The Fotona SP Spectro Systems consist of a range of noninvasive laser treatments that work together synergistically to tighten the collagen in four dimensions and provide long‐lasting firmness to the face. The Fotona SP Spectro combines two wavelengths: Er:YAG (2940 nm) and Nd:YAG (1064 nm) with four distinct treatments: SmoothLiftingTM, FRAC3®, PIANO®, and SupErficialTM, allowing safe, painless, noninvasive, and no downtime rejuvenation.AimsTo present a new protocol of treatment with Fotona SP Spectro for eyebrow elevation, which we call fox eyes lift (FEL), and compare it to the standard SmoothEye® (SE) protocol.MethodsThis is a prospective, interventional, split‐face study. The sample consisted of 21 subjects (19 women) with a mean age of 50.1 ± 7.9 years who underwent two different protocols, that is, SE on one side and FEL on the other. The protocol used on each side was selected by drawing lots. Three sessions were held at 1‐month intervals. Standardized photographic documentation was obtained before and 30 days after the end of treatment. Eyebrow position before and after complete treatment was quantified using ImageJ software.ResultsStatistical analysis by ANOVA showed a significant improvement in eyebrow position after treatment with both protocols, with a significantly greater effect of FEL (p = 0.0003 d = 0.95).ConclusionFox eyes lift is an efficient and safe technique providing significant improvement in the position of the eyebrow.
Redefining sexual health after gynaecological cancer: Lived experiences from Gynea, a digital rehabilitation programme
Authors: Breistig Sigrund , Thorkildsen Kari Marie , Werner Henrica Maria Johanna , Nordgreen Tine , Sekse Ragnhild Johanne Tveit 
Published: November 2023

AbstractBackgroundGynaecological cancer illness and treatment have a significant impact on women's sexual health and concerns regarding sexual health are known to be an unmet need in survivors. The digital support programme Gynea was designed to enhance women's health, including sexual health, after gynaecological cancer treatment. This study aimed to explore how cancer survivors experienced participation in Gynea.MethodologyThis is a phenomenological hermeneutic study. Individual, in‐depth semi‐structured interviews were conducted to explore lived experiences. Twenty women were interviewed after completing the Gynea programme. The transcripts were analysed using Lindseth and Norberg's phenomenological hermeneutic method.FindingsThree main themes (with subthemes) emerged from the analysis: (1) A silent existential trauma; (2) Redefining sexual health; (3) Communicating with a partner about sexuality. The women redefined sexual health rather than just being sexual intercourse, being a rediscovery of the body. The women's increased awareness and understanding of their own sexual health empowered their communication about their sexuality with their partners. This was important for regaining sexual health and intimacy in their relationships.ConclusionParticipation in Gynea helped to strengthen the women's sexual integrity. Knowledge and support empowered them to take care of their sexual needs and communicate these with their partners.Implications for Patient CareHealthcare services and nurses need to be aware that sexual health is an existential state of being, in which good sexual health does not necessarily equate to sexual function, but rather to sexual empowerment. Digital support with nurse guidance can support women in caring for their sexual health after cancer illness by thematizing sexual health with a holistic approach and should be part of the medical treatment.Patient or Public ContributionTwenty gynaecological cancer survivors contributed by sharing their experiences from the sexual health module in Gynea.