bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durability of first-line antiretroviral treatment in the Russian Federation: retrospective study
Authors: Sizova N. V. , Plotnikova Yu. K. , Shimonova T. E. , Chernova O. E. , Ivanova E. S. , Obizhaeva E. S. , Achikyan V. F. 
Published: October 2023

Objective. To assess durability of antiretroviral therapy in first line in HIV-infected patients in real clinical practice in the Russian Federation and determine association between basic clinical and demographic characteristics and durability of treatment.Materials and methods. A non-interventional retrospective study was conducted collecting data from primary medical records of HIV-infected patients who signed informed consent form and had started antiretroviral therapy in first line. Patients were enrolled if the third component was a non-nucleoside reverse transcriptase inhibitor (NNRTI) or ritonavir boosted protease inhibitor (PI/r) plus two nucleoside reverse transcriptase inhibitors (NRTIs). Also, patients must have been followed up for at least 96 since start of treatment. Durability of therapy was retrospectively assessed at 48±8 and 96±8.Results. 536 patients were enrolled. Percentage of patients without change of therapy was approximately 76% and 60%, and the mean duration of therapy without changes was approximately 47 and 79 weeks at 48±8 and 96±8 weeks, correspondingly. Durability of treatment was not different for NNRTI+2NRTIs and PI/r+2NRTIs. Only age ≥ 40 years as a basic characteristic was associated with ART change prior to 96 weeks: OR=1.391, 95% CI 1.005-1.925.Conclusions. In real clinical practice in Russia, durability of first-line antiretroviral therapy corresponds published scientific data (in terms of percentage of patients without change of treatment and its duration without change). Durability of treatment and factors associated with its early switch or stop should be investigated in prospective studies further.
Features of the functioning of the innate and adaptive immunity system in patients with COVID-19 of the older age group
Authors: Scheglovitova O. N. , Kolobukhina L. V. , Babayants A. A. , Frolova I. S. , Isaeva E. I. , Kruzhkova I. S. , Samkov A. A. , Antipyat N. A. , Tyurin I. N. , Narovliansky A. N. , Ershov F. I. 
Published: October 2023

Goal. Characteristics of innate, cellular and adaptive immunity in patients of the older age group with COVID19.Materials and methods. Blood leukocytes were induced by Newcastle disease virus (α-interferon), phytohemagglutinin (γ-interferon), SARS CoV 2: RBD antigens and S-protein; interferon activity in human fibroblast culture and enzyme immunoassay were evaluated. In serum, IgG antibodies to SARS CoV2 and autoantibodies to interferon and to the endothelium of blood vessels were determined using a mono-layer of human umbilical vein cells. Statistical processing was performed in Excel 2016.Results. A decrease in the production of α-interferon and γ-interferon was revealed: 1 week -74.2±15.1; 3 week-144.0±35.7 (p=0.01); control – 266.6 ±82 (relative to 3 weeks p=0.004) and IFN γ: 1 week -6.8±2; 3 week – 14.4 ±3.5 (p=0.03); control – 28.87.15 (relative to 3 weeks (p=0.007). Decreased production of γ-interferon by leukocytes of patients with induction by SARS CoV2 RBD and S-trimer anti-gens was revealed. Antibodies to SARS CoV2 were detected starting from the 2nd week of the disease, a large spread of indicators was noted. Autoantibodies to α2-interferon and to vascular surface antigens were detected.Conclusion. The state of innate immunity in patients of the older age group with severe and moderate COVID-19 was characterized by a decrease in the activity of the interferon system. Decreased activity of cellular immunity to SARS CoV2 antigens was noted. Adaptive immunity was characterized by the development of an imbalance in the form of the appearance of autoantibodies to α-interferon and vascular endothelium.
Revisiting Uşak Terakki-i Ziraat Turkish Joint Stock Company (1925–1931): A Case Study of Turkey’s Early Financial Reporting Culture
Authors: Güvemli Batuhan , Aslan Muhsin 
Published: October 2023

ABSTRACT
This research offers an in-depth examination of the early financial reporting culture in Republican Turkey, using the Uşak Terakki-i Ziraat Turkish Joint Stock Company (Uşak Sugar Company) as a case study. The analysis of the company's financial statements from 1925 and 1931 reveals the development of financial reporting practices during a transformative period, marked by industrialization efforts and the introduction of the 1926 Turkish Commercial Code and Income Tax Law. The study identifies both progress and challenges in financial reporting, including detailed fixed assets classifications, accounting irregularities, inadequate auditing and working capital management practices. The findings indicate that these issues, alongside macroeconomic factors, have contributed to the company’s liquidation in 1932. This failure could have indirectly catalyzed a shift toward statist economic policies in the 1930s.
JEL Classifications: M41; O14.
Comparative Efficacy of Certain IPM Strategies Against Tobacco Caterpillar and Head Borer in Sunflower
Authors: Dhinda B. , Nayak U. S. , Das C. K. , Panda S. 
Published: October 2023

The Experiments was conducted at Regional Research and Technology Transfer Station, Ranital, Bhadrak, OUAT(Odisha University of Agriculture and Technology), Odisha, India during the summer seasons(Jan-may) of 2019–20 and 2020–21 to evaluate the comparative efficacy some IPM modules against the head borer and leaf eating caterpillar in sunflower. Five IPM modules(three chemo-intensive and two bio-intensive modules) were evaluated against the existing pesticides application-based farmers’ practice. The results revealed that the IPM module (M2) comprising of installation of pheromone traps for pest monitoring @ 5 ha-1, poison baits (10 kg rice bran+2 kg jaggery+100 g Thiodicarb 70WP) for attracting and killing of tobacco caterpillar larvae and alternate spray of neem oil formulations (1500 ppm) @ 1.5 l ha-1 and the novel insecticide mixed formulation (Novaluron 5.25%+Emamectin benzoate 0.9% SC) @ 825 ml ha-1 at 15 days interval had significantly suppressed tobacco caterpillar (5.46% leaf damage i.e.. 67.59% reduction over FP) and sunflower head (2.93% head damage i.e. 75.32% deduction over FP). The IPM module ( M3) comprising of pheromone trap installation @ 5 each ha-1,poison baits (10 kg rice bran+2 kg jaggery+200 ml deltamethrin 5EC) and alternate spray of neem oil formulations (1500 ppm) @ 1.5 l ha-1 and Flubendiamide 480 SC @ 150 ml ha-1) also had statistically similar efficacy against the target pests with 6.40% leaf damage (62.02% reduction over FP) and 3.54% head damage(70.17% reduction over FP). Though, the BIPM module had moderate efficacy against the insect-pests under study, retained maximum population of predatory fauna like predatory bug (Eocanthecona furcellata) and lady bird beetles in the sunflower ecosystem.
Implantable-cardioverter-defibrillator after ST-elevation myocardial infarction: when and how frequently is it implanted and what is the rate of appropriate interventions? Insight from Trieste registry
Authors: Pezzato Andrea , Fabris Enrico , Gregorio Caterina , Cittar Marco , Contessi Stefano , Carriere Cosimo , Lardieri Gerardina , Zecchin Massimo , Perkan Andrea , Sinagra Gianfranco 
Published: October 2023

Background
There are limited data on implantable-cardioverter-defibrillator (ICD) implantation after ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Therefore, we evaluated when and how frequently an ICD is implanted after pPCI, the rate of appropriate ICD interventions, and predictors of ICD implantation.

Methods
We analyzed STEMI patients treated with pPCI at the University Hospital of Trieste, Italy, between January 2010 and December 2019. We cross-matched patients’ data with those present in the Trieste ICD registry.

Results
Among 1805 consecutive patients treated with pPCI, 3.6% underwent ICD implantation during a median follow-up of 6.7 [interquartile range (IQR) 4.3–9.2] years. At 12 months, the mean number of ICD implantations was 2.3/100 patients [95% confidence interval (95% CI) 1.7–3.1] and remained stable over time (at 24 months: 2.5/100 patients, 95% CI 2.0–3.5 and at 36 months: 2.6/100 patients, 95% CI 2.3–3.8); 83.1% of ICDs were implanted for primary prevention, and more than half (55%) were implanted in patients with ejection fraction more than 35% at the moment of STEMI discharge. The rate of appropriate ICD interventions was 16.9% at a median follow-up of 5.7 years (IQR 3.3–8.3 years) after ICD implantation. At 12 months, the mean number of appropriate ICD interventions was 5/100 patients and 7/100 patients after 24 months. In patients with ejection fraction more than 35% at STEMI discharge (median ejection fraction 43%; IQR 40–48), independent predictors of ICD implantation were male sex, anterior STEMI and troponin peak more than 100 000 ng/dl.

Conclusion
The rate of ICD implantations after pPCI is low; however, the rate of appropriate ICD interventions is high. A relevant subgroup of patients received ICD implantations at follow-up despite a nonsevere ejection fraction at discharge after STEMI. Among these patients, those with high troponin release deserve strict follow-up and full optimal medical treatment.
The use of role-playing in German as a foreign language class in Albania
Authors: Shahinaj Livia 
Published: October 2023

Abstract
Role playing in German as a foreign language is very important in understanding its context. This manuscript consists of the following sections:

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Definition of role play;

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How does it help students of German language?

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What does role play offer to students?

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Do we find role play exercises in books?

Regarding these issues a google form survey was distributed to students of German language. In this context main purpose of this survey is to check whether the role play exercises are part of the lesson, unit and therefore the learning process.
VALIDATION OF A TOOL TO MEASURE THE LEVEL OF SCHOOL-UNIVERSITY PARTNERSHIP
Authors: Thuy Hong Cao , Thi Lan Anh Tran 
Published: October 2023

This study aims at developing and validating an audit tool that could be used to assess school-university partnerships. Specifically, the study followed four steps of (i) evaluating and modifying contents and items of the original tool, (ii) qualitatively assessing content validity of the revised scale basing on expert ratings, and revising the scale accordingly, (iii) conducting cognitive interviews with potential participants, and making further revision, and (iv) quantitatively evaluating the validity and reliability of the audit tool based on data collected from 463 participants, and finalizing the tool. In the end, an audit tool consisting of 36 questions that fit into two scales (i.e., “Shared goals and values” and “Partnership operations and management”) was confirmed. The study also discussed potential uses of the tool for both currently working partnerships and newly formed partnerships; and at different levels.
Ocular blood flow in normal tension glaucoma and primary open angle glaucoma
Authors: Kundan Shimpa , Joseph Rachel , Shetty Jyoti , Ballal Sheetal 
Published: October 2023

Objectives:
The purpose of the study was to study the ocular blood flow (OBF) in primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) by color Doppler imaging (CDI) in the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary artery (PCA) and to correlate this with structural and functional damage in glaucoma.

Materials and Methods:
This was a cross-sectional and observational study. This was a cross-sectional study, in which 30 eyes of each group and controls were studied, CDI was done by a single observer for all cases. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) were calculated for OA, CRA, and PCA. Visual fields and retinal nerve fiber layer (RNFL) analysis were done.

Results:
PSVs and EDVs were lower and RIs were higher for CRA and PCA of NTG and POAG compared to those of controls. The severity of glaucoma (visual field defect) increased when RI of OA was increased in NTG. No such relationship was established between RNFL thinning and OBF.

Conclusion:
Reduction in PSV and EDV leads to increased RI which is one of the contributory factors in the functional damage in NTG.
Pengembangan Panduan Parenting Berbasis Android Untuk Meningkatkan Komunikasi Verbal Anak Spektrum Autis
Authors: Rohman Aris Taufiqur , Andajani Sri Joeda , Sartinah Endang Pudjiastuti 
Published: October 2023

Rendahnya kemampuan berkomunikasi verbal anak autis dalam kehidupan sehari-hari dan kurangnya pemahaman orangtua tentang cara mengajarkan komunikasi verbal tersebut, menjadi kendala perkembangan berkomunikasi anak autis. Penelitian ini bertujuan untuk menghasilkan produk panduan parenting berbasis android bagi orangtua dalam mengajarkan komunikasi verbal pada anak autis. Metode penelitian yang digunakan adalah 4D dengan tahapan Define (Pendefinisian), Design (Perencanaan) Develop (Pengembangan) dan Disseminate (Penyebaran). Penelitian ini dilaksanakan dalam tiga tahap pengembangan karena adanya pandemi Covid-19 sehingga belum memungkinkan untuk dilakukan penyebaran. Teknik pengambilan data dilakukan dengan menggunakan lembar validasi ahli yang meliputi ahli media dan ahli materi. Hasil penelitian menunjukkan bahwa panduan parenting berbasis android yang dikembangkan telah memenuhi aspek kevalidan sehingga layak digunakan. Aspek kevalidan ditunjukkan hasil validasi media sebesar 77%, dan hasil validasi materi sebesar 78,6%. Berdasarkan nilai uji validitas dapat diinterpretasikan bahwa panduan parenting berbasis android untuk meningkatkan komunikasi verbal anak spektrum autis valid untuk diimplementasikan secara terbatas dan di evaluasi kembali.

Kata Kunci: Parenting, Android, Komunikasi, Anak Autis
Pengembangan Tutorial Toilet Training Peserta Didik Autis Berbasis Web Format Mobile Version Bagi Guru di Sekolah Inklusi
Authors: Idah Pertiwi Shinta , Wagino Wagino , Mudjito Mudjito 
Published: October 2023

Penelitian ini bertujuan untuk menghasilkan produk berupa Tutorial Toilet training Peserta Didik Autis Berbasis Web Format Mobile version Bagi Guru di Sekolah Inklusi dan mendeskripsikan validitas produk dari ahli materi, dan ahli materi. Desain penelitian menggunakan desain pengembangan ADDIE dari Branch 2010 yang dimodifikasi hanya sampai ke tahap pengembangan (development). Teknik pengumpulan data meliputi proses pengembangan data dengan teknik validasi yang dilakukan oleh ahli materi, dan ahli media. Untuk mengetahui bahwa produk ini berkualitas baik dan layak dengan melihat hasil analisis skor instrumen validasi ahli. Dari data uji validasi ahli, mendapatkan skor persentase 96,4% dan dari ahli materi, skor persentase 83,8%. Berdasarkan hasil validasi ahli materi, dan ahli media, menunjukkan bahwa Tutorial Toilet training Peserta Didik Autis Berbasis Web Format Mobile version Bagi Guru di Sekolah Inklusi layak digunakan untuk pembelajaran siswa autis.
Kata Kunci: Toilet Training, Web, Autis
Pengembangan Literasi Bahan Ajar Tema 1 Diriku Berbasis Aplikasi Lip Motion Bagi Siswa Tunarungu
Authors: Gita Pralistyo Putri Ariensa , Yuliyati Yuliyati , Purbaningrum Endang 
Published: October 2023

Siswa tunarungu mengalami hambatan dalam mengikuti pembelajaran secara online di masa pandemi, terlebih pada pembelajaran literasi. Sebuah alternatif diperlukan untuk memecahkan permasalahan agar siswa tunarungu dapat belajar dan mengembangkan literasi dari rumah. Sejalan dengan berkembangnya teknologi, pengembangan aplikasi sebagai media pembelajaran menjadi sorotan. Berdasarkan kajian tersebut, penelitian ini menawarkan konsep pengembangan literasi yang dikemas dalam bentuk aplikasi Lip Motion. Dengan aplikasi Lip Motion, siswa tunarungu dapat memahami pesan yang disampaikan melalui penguatan oral dalam bentuk video yang diperankan oleh manusia. Metode penelitian Research & Development (R&D) dengan model ADDIE, terbatas menggunakan tiga tahapan yaitu tahap analisis, perencanaan, dan pengembangan. Tahap implementasi dan evaluasi tidak dapat dilakukan sebagai dampak dari pandemi Covid-19, dimana pembelajaran tatap muka di sekolah belum diberlakukan. Pada penelitian ini, aplikasi Lip Motion sudah terbukti layak menurut ahli materi dengan perolehan nilai 80%, ahli media dengan perolehan nilai 98%, dan terbukti praktis menurut praktisi dengan perolehan nilai 93%.
Kata Kunci: Literasi, Aplikasi Lip Motion, Siswa Tunarungu
Pengembangan Media Video Pembelajaran Agama Katolik Berbantuan Bisindo di Komunitas Tunarungu Katolik
Authors: Sofiarti Melania Safirista , Murtadlo Murtadlo , Sartinah Endang Pujiastuti 
Published: October 2023

Penelitian ini bertujuan untuk mengembangkan media video pembelajaran agama Katolik berbantuan Bahasa Isyarat Indonesia di komunitas Tunarungu Katolik. Hal ini bertujuan untuk mengatasi keterbatasan komunitas tunarungu dalam penguasaan ketrampilan berbahasa serta pemahaman tentang ajaran Agama Katolik. Metode penelitian yang digunakan adalah ADDIE, yaitu metode pengembangan dari model instruksional. Media video pembelajaran ini dibuat menyesuaikan karakter belajar komunitas tunarungu, yakni dengan Bahasa Isyarat Indonesia dan disediakan teks atau terjemahan. Hasil presentase dari masing-masing penguji menunjukkan bahwa media video pembelajaran agama Katolik ini layak digunakan dengan presentase sebesar 85% dari ahli materi tunarungu, 95% dari ahli materi agama katolik, dan 81% dari ahli media. Dengan adanya media video pembelajaran ini, diharapkan umat Tunarungu Katolik dapat memperoleh pemahaman yang lebih baik tentang agama Katolik serta ibadah hari Minggu, dan juga dapat meningkatkan akses mereka terhadap informasi dan pemahaman ajaran agama.
Kata Kunci: Tunarungu, Bahasa Isyarat, Agama Katolik, Video
Microthermometric characteristics of Şaphane (Oğuzlar-Çorum) Au mineralisation, Turkey
Authors: KULAMAN Çağlar , ÜNAL ÇAKIR Esra 
Published: October 2023

The study area is located in the Çorum province, in the Central-Inner Black Sea region, North-Central part of Turkey. In the Çorum region various continental blocks are found together. Devecidağ Complex, Artova Ophiolite Complex, Alacahöyük, Bayat, Kızılırmak, Dodurga and Bozkır formations and Dededağ granitoid and quartz veins are exposed in the vicinity of the study area. Extremely altered volcanic rocks, andesite-basalt-trachyte and tuffs are observed near the mineralisation. The silica veins associated with the mineralisation crop out in NE-SW direction southeast of Şaphane village. Pyrite, hematite, limonite and gold are the major ore minerals within the quartz veins.
In the fluid inclusion studies, it was determined that hydrothermal solutions contain several salts such as NaCl, CaCl2 and MgCl2, the salinity values (wt.% NaCl) changed between 8% and 0.5% in quartz, from 7.4 and 1.4% in calcite, and the temperature of the solutions varied between 161 and 395°C. Available data indicate that the mineralisation in the region is associated with quartz veins and formed under epithermal-mesothermal conditions.
Sustainable Growth of Greenhouses: Investigating Key Enablers and Impacts
Authors: Durmanov Akmal , Saidaxmedova Nodira , Mamatkulov Murodjon , Rakhimova Khavakhon , Askarov Nazimjon , Khamrayeva Shakhnoza , Mukhtorov Abdukholik , Khodjimukhamedova Shakhida , Madumarov Talantbek , Kurbanova Khurshida 
Published: October 2023

The main objective of this study was to identify the factors influencing greenhouse development in Uzbekistan. Supported by the literature, the conceptual model of the study hypothesized that economic viability, supportive infrastructure services, enablers, and competition impacts positively affect greenhouse development. Therefore, a questionnaire was administered among 200 individuals working in greenhouses across the Tashkent, Syrdarya, Jizzakh, and Bukhara regions. Quantitative empirical evidence using structural equation modeling revealed that enablers and competition impacts have a significant positive influence on greenhouse development. However, economic viability and supportive infrastructure services did not have a direct impact, although they indirectly contributed to the overall growth and functioning of the greenhouse industry. The study provides theoretical contributions by identifying key factors influencing greenhouse development and offers practical recommendations for policymakers and stakeholders to foster an enabling environment, manage competition effectively, enhance supportive infrastructure, promote international collaboration and investment, encourage research and development, and strengthen market linkages. This research contributes to the understanding of greenhouse development in Uzbekistan and provides insights for evidence-based decision-making and strategic planning in the industry. Doi: 10.28991/ESJ-2023-07-05-014 Full Text: PDF
The Magic of Brand Experience: A Value Co-creation Perspective of Brand Equity on Short-form Video Platforms
Authors: Ruangkanjanases Athapol , Khan Asif , Sivarak Ornlatcha , Rahardja Untung , Chien Shih-Wen , Chen Shih-Chih 
Published: October 2023

Many companies are utilizing short-form video platforms to enhance the value co-creation between brands and consumers and ultimately create brand equity. However, there is a research gap in the present literature regarding the significance of consumers' participation in short-form video platforms affecting corporate brand equity. The present study aims to address this research gap by incorporating value co-creation theory to investigate the role and mechanism of value co-creation generated by consumer participation in short-form video platforms, i.e., corporate-initiated value co-creation and customer-initiated value co-creation, on corporate brand equity. The current study used a survey methodology to collect 481 samples from TikTok users using a convenience sampling method. The present study used structural equation modeling on the collected data. The findings show that corporate-initiated value co-creation can positively influence corporate brand equity, in which brand experience plays a partially mediating role. Customer-initiated value co-creation can also promote brand equity, whose role is also partially mediated by brand experience. This study theoretically contributes to the value co-creation concept and its theoretical association with brand equity and brand experience. This research also offers practical implications for practitioners regarding the utilization and enhancement of brand experience to improve clients' engagement in value co-creation activities. Doi: 10.28991/ESJ-2023-07-05-09 Full Text: PDF