bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stages of reengineering the information system of the enterprise within the framework of zero trust technology
Authors: Валеев С.С. , Кондратьева Н.В. , Гузаиров М.Б. , Мельников А.В. 
Published: December 2023

Развитие информационных систем предприятия связано с необходимостью поддержки удаленной работы сотрудников. Причины могут носить разный характер. В этих условиях обеспечить защиту периметра предприятия достаточно сложно на основе существующей парадигмы защиты периметра. В настоящее время активно развиваются и внедряются системы защиты на основе архитектуры нулевого доверия. В статье проведен анализ особенностей внедрения этой технологии на предприятии, где применяются традиционные системы защиты информации, основанные на использовании VPN-технологий и межсетевых экранов. Рассматриваются основные шаги, которые позволят в случае необходимости поэтапно выполнить переход на архитектуру нулевого доверия.
The development of enterprise information systems is associated with the need to support remote work of employees. The reasons may be of a different nature. Under these conditions, it is quite difficult to provide enterprise perimeter protection based on the existing perimeter protection paradigm. Currently, protection systems based on zero trust architecture are being actively developed and implemented. The article analyzes the features of the implementation of this technology in an enterprise that uses a traditional information security system based on the use of VPN technologies and firewalls. The main steps are considered that will allow, if necessary, a phased transition to a zero-trust architecture.
Development of an algorithm for data backup to cloud storage
Authors: Харитонов К.А. , Ступина М.В. 
Published: December 2023

Рассмотрены современные подходы к резервному копированию данных. Проанализированы различные факторы, которые влияют на выбор метода резервного копирования: местоположение резервного сервера, законодательные требования, частота и объем резервных копий, скорость сети для передачи данных. Проведен сравнительный анализ двух методов резервного копирования, на основе которого был выбран метод D2D2C для резервирования копий в облачном хранилище. Данный метод позволяет эффективно защищать данные информационной системы и обеспечивает быстрое их восстановление в случае их потери. Представлена реализация алгоритма резервного копирования в облачное хранилище связанных данных, позволяющая проводить резервное копирование при работающей системе без прерывания работы. Данный подход обеспечивает более высокую отказоустойчивость и гарантирует сохранность данных в случае сбоя в работе системы.
In this paper, modern approaches to data backup were considered. Various factors that influence the choice of backup method were analyzed, such as the location of the backup server, legal requirements, the frequency and volume of backups, as well as the network speed for data transmission. A comparative analysis of two backup methods was carried out, on the basis of which the D2D2C method was chosen in which the backup copy is stored in cloud storage. This method allows you to effectively protect IP data and provides fast data recovery in case of loss. In addition, the implementation of a backup algorithm to the cloud storage of related data was presented, which allows you to back up when the system is running without interrupting work. This approach provides higher fault tolerance and guarantees the safety of data in the event of a system failure.
Improving methods and processes to ensure the reliability of the radio navigation system of medium-haul aircraft
Authors: Нгиа Б.Ч. , Чонг Н.В. , Пащенко Ф.Ф. , Фук В.Х. , Тиеп Л.Д. 
Published: December 2023

В практике полетов продолжают встречаться случаи полных и функциональных отказов навигационных датчиков и компьютеров, погрешностей измерения навигационных параметров, которые выходят за допустимые пределы, а также различные нарушения в функционировании аэронавигационной системы обеспечения полетов среднемагистральных самолетов. Такие ситуации снижают способность навигации соответствовать требованиям к аэронавигационной точности из-за возможных отклонений, которые приводят к снижению навигационных возможностей воздушных судов. Для этого рассмотрена методика совершенствования интегрированных инерциально-спутниковых радионавигационных систем для увеличения точности среднемагистральных самолетов.
In the practice of flights, there continue to be cases of complete and functional failures of navigation sensors and computers, errors in measuring navigation parameters that go beyond the permissible limits, as well as various violations in the functioning of the aeronautical system for ensuring flights of medium-haul aircraft. Such situations reduce the ability of navigation to meet the requirements for aeronautical accuracy due to possible deviations that lead to a decrease in the navigation capabilities of aircraft. For this purpose, the methodology of improving integrated inertial satellite radio navigation systems to increase the accuracy of medium-haul aircraft is considered.
Postmodernizm i ponowoczesność w świetle rozwoju technologii cyfrowych i procesu indywidualizacji
Authors: Pieniążek Paweł 
Published: December 2023

Celem artykułu jest skonfrontowanie postmodernizmu rozumianego jako doktryna filozoficzna, czy, szerzej, pewien typ świadomości kulturowej z ponowoczesnością jako epoką stanowiącą wyraz przemian późnego kapitalizmu. Związki między postmodernizmem I ponowoczesnością analizowane są w perspektywie filozoficzno-socjologicznej poprzez porównanie diagnoz ponowoczesnych przemian przedstawionych przez przedstawicieli postmodernizmu i diagnoz przedstawionych przez socjologów ponowoczesności. W pierwszej części omawiam znaczenie technologii cyfrowych, w których postmoderniści pokładali nadzieję na wyzwolenie potencjału ludzkiej kreatywności, w drugim ponowoczesne procesy indywidualizacji związane z ideą samorealizacji. W konkluzji dochodzę do przekonania, że ponowoczesność sprzeniewierzyła się głoszonym przez postmodernizm ideom wolności, kreatywności, samorealizacji, solidarności.
W konkluzji wyrażam przekonanie, że ponowoczesność sprzeniewierzyła się ideom wolności, kreatywności, samorealizacji, solidarności głoszonym przez postmodernistów, które zgodnie z ich nadzieją miała ona urzeczywistnić.
Language Proficiency and Sonorant Devoicing in English Plosive-Sonorant Clusters
Authors: Přečková Klára , Šturm Pavel , Volín Jan 
Published: December 2023

This article explores the timing of phonetic voicing in plosive-sonorant clusters in English. VOT was measured in two groups of Czech learners with different proficiency levels and a native English control group. The hypothesis was that cross-language differences in the implementation of the voicing contrast would be reflected in lower devoicing by the non-native speakers, modulated by proficiency. 24 participants read a text with plosive-sonorant clusters (such as in plan or troops). The study found that less proficient speakers exhibited smaller degrees of devoicing compared to more proficient speakers, who however did not differ from the native controls. In line with the absence of devoicing in Czech secondary-school textbooks, the results provide insight into the interplay between language proficiency and pronunciation details in L2 acquisition.

The research was supported by the European Regional Development Fund-Project ‘Creativity and Adaptability as Conditions of the Success of Europe in an Interrelated World’ (No. CZ.02.1.01/0.0/0.0/16_019/0000734). The study was created within the Charles University programme ‘Cooperatio’, scientific field Linguistics.
ALTERAÇÕES NOS PARÂMETROS SANGUÍNEOS E MORFOFISIOLÓGICO HEPÁTICO EM TILÁPIA-DO-NILO, OREOCHROMIS NILOTICUS, APÓS EXPOSIÇÃO AGUDA COM BIOINSETICIDA A BASE DE BACILLUS THURINGIENSIS
Authors: Do Carmo da Silva Ducilene , Rubens Rodrigues Ferreira Ericsson , Estevan Moron Sandro , Dos Santos Mariano Wagner , Paulino Marcelo Gustavo 
Published: December 2023

Os biopesticidas visam substituir pesticidas sintéticos, sendo que, os formulados a base de Bacillus thuringiensis (Bt) os mais empregados nas lavouras. Todavia, é pouco conhecido o seu mecanismo de ação e efeitos sob a biota aquática. O objetivo foi avaliar os efeitos subletais do Bt em tilápia-do-Nilo após exposição aguda. Os peixes foram divididos em um grupo controle (GC), um exposto à 30 mg L-1 do biopesticida (G30) e um exposto a 40 mg L-1 do Bt (G40), por 48 horas. Após exposição, amostras de sangue e fígado foram coletadas para análise de toxicidade. O número de eritrócitos com núcleos lobulados e reniformes aumentou, mas sem observância de micronúcleos. Não houve alteração nos parâmetros eritrocitários, todavia, o número de leucócitos totais e trombócitos aumentou nos tratados. Alterações histopatológicas hepáticas foram evidenciadas por um aumento de inclusões intracelulares, alteração nucleares e diminuição de hepatócitos hipertrofiados entre os tratados. O Iorg demostrou comprometimento do tecido hepático no grupo G30 em relação ao controle e entre tratados. Os danos resultantes da exposição ao Bt podem ser severos, mesmos sendo categorizados como reversíveis. Concentrações baixas de Bt podem induzir efeitos deletérios para peixes, interferir no sistema imune e citológico do sangue e fígado.
Quo Vadis: Regulating Independence Coaching for Death Row Inmates in Indonesian Correctional System
Authors: Utami Niken Subekti Budi , Sudiarsana I Kadek 
Published: December 2023

<em>The death penalty, one of the punishment types regulated in the Indonesian Criminal Code, continues to be imposed despite conflicts between abolitionists and retentionists. The existence of the death penalty in Indonesia has a legal consequence, which is the need for legal certainty regarding the status of death convicts, who are often entrusted to a Correctional Facility during the waiting period for execution. The enactment of Law Number 22 of 2022 classifying death row inmates as prisoners, along with their rights and obligations. This research uses legal research supported by data from interviews with experts. Data obtained from literature research was analyzed descriptive-qualitatively. The result showed that death row inmates must participate in coaching programs like other prisoners. The coaching program was divided into two parts: character and independence coaching. From the aspect of practicality, character coaching is more beneficial for death row inmates compared to independence coaching, as death row inmates would not return to society and would be waiting for their execution time unless their clemency request was granted. </em>
Dynamics Encounter of Tradition and Religion in the Wedding Parade (Baarak Bako) in Solok City West Sumatra
Authors: Azwar Zainal , Majid Hamidun , Firdaus Firdaus , Zulfan Zulfan , Arlis Arlis 
Published: December 2023

Islamic Sharia stipulates that marriages must be announced to the public. One method of the announcement is through walīmat al-‘urs, translated differently in different Muslim communities. In the city of Solok, West Sumatra, one of the forms of walīmat al-‘urs is the baarak bako tradition (a wedding parade around the village). Baarak bako's implementation frequently clashes with obligatory prayer times in Islam, causing many participants to leave the prayer. This research aims to examine the background of the baarak bako tradition, the reasons for deciding the time to perform baarak bako, and the effects of baarak bako on prayer services. Using a qualitative method, this article revealed that the origin of baarak bako was the desire of the bako (father's female family) to show their presence by enlivening anak pisang's (the children of a brother) wedding. According to the custom, the best time to announce a marriage is in the afternoon because people are already at home and have finished their activities outside the home; the implementation of baarak bako resulted in some participants failing to perform the obligatory prayers. The neglected prayers are carried out in jama' (merging two prayers). Others, on the other hand, leave the prayer without jama'. The people of Solok City are very rigorous about following customary rules. When religious law and customary law rules conflict, some people prefer customary rules over religious rules and vice versa. These findings show the dynamic relationship between religion and customs in the Minangkabau ethnic group, West Sumatra. These two norms can coexist and adapt to each other in practice.
Keywords: Islamic law, prayers, marriage, tradition, baarak bako.
Research on Performance Failure Caused by Gas Blocking in Multiphase Mixed-Transport Pump under Non-uniform Inflow Conditions
Authors: Quan Hui , Wang Zhisheng , Du Yuanying , Su Houde 
Published: December 2023

Abstract

The helical-axial multiphase mixed-transport pump fails due to gas blocking caused by gas-liquid separation caused by cavitation under complex conditions with high gas volume fraction. This is an urgent engineering problem that needs to be addressed in the application of this pump. In order to simulate the flow structure characteristics in the channel, two types of non-uniform inflow boundary conditions are introduced. The bubble structure, velocity, and pressure of the inflow conditions under different operating conditions are compared and analyzed, and the variation rules affected by the non-uniform boundary conditions are obtained. At the same time, the internal flow characteristics and mechanisms of helical-axial multiphase mixed-transport pumps are analyzed based on the velocity changes at the inlet of the impeller and the pressure fluctuations at the outlet of the diffuser, leading to the intensification of gas-liquid separation and eventually the development of gas blocking. Research has shown that through programmatic control of the inlet boundary conditions, a linear change in inlet pressure has a more significant effect on the intensification of gas-liquid separation in the flow channel of the mixed transport pump than a sinusoidal change, ultimately leading to significant performance failure when generating gas blocking. The research conclusion provides reference value for solving gas blocking in engineering applications of helical-axial multiphase mixed-transport pump.
Human umbilical cord mesenchymal stem cells for the treatment of systemic lupus erythematosus via glucose metabolism of CD4 + T cells
Authors: Ding Meng , Jin Lu , Cui Shaoxin , Yang Lin , He Jingjing , Wang Xiaoping , Chang Fei , Wang Qun , Liu Xue , Jin Hongtao , Song Shuran , Shi Min , Ma Jun , Liu Aijing 
Published: December 2023

Abstract
Background: T cells play a crucial role in the development of systemic lupus erythematosus(SLE), and their function is mediated by various metabolic pathways and enzyme activities. Here, we aim to analyze the phenotype of glucose metabolism of peripheral blood CD4+ T cells. Also, the effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on the proliferation, function, and glucose metabolism of peripheral blood CD4+ T cells in SLE patients were assessed to elucidate the pathogenesis of SLE and the therapeutic mechanism of hUC-MSCs based on metabolic reprogramming.
Methods: The clinical data and peripheral blood of 15 SLE patients and healthy controls were collected. CD4+ T cells were isolated via immunomagnetic beads followed by activation in presence of anti-CD3/CD28 in vitro. After 72h co-culture of with hUC-MSCs, CD4+ T cell viability was detected by CCK-8 assay. The Seahorse Bioscience XFe24 Extracellular Flux Analyzer was used to measure the oxygen consumption rate(OCR) and glycolytic proton efflux rate(glycoPER) of CD4+ T cells. Multiplex cytokine assay was conducted to detect the cytokines in the supernatant. The expression of genes was determined and identified by transcriptome sequencing.
Results: Compared to the healthy controls, the OCR and glycoPER levels of activated CD4+ T cells were greatly increased in SLE (P<0.05). After 72h co-culture with hUC-MSCs, the OCR, glycoPER, cell viability and proinflammatory factors of SLE-CD4+ T cells decreased considerably(P<0.01). The mRNA levels of 434 genes were upregulated, and 172 genes were downregulated; this phenomenon was pronounced in the JAK-STAT and PI3K-Akt pathways.
Conclusion: The levels of oxidative phosphorylation and glycolysis of CD4+ T cells were considerably increased in SLE patients, indicating that the glucose metabolism phenotype of CD4+ T cells, a potential therapeutic target, was closely related to the pathogenesis of the disease. hUC-MSCs reduced the proliferation activity of SLE-CD4+ T cells, altered the phenotype of glucose metabolism, reduced the level of proinflammatory factors, and increased the level of anti-inflammatory factors. The regulatory effects of MSC on the cellular energy metabolism phenotype may be related to the influence of JAK-STAT and PI3K-Akt signaling pathways.
Altimetry-based ice-marginal lake water level changes in Greenland: Unveiling annual variations in glacial lake outburst floods linked to runoff
Authors: Doemgaard Mads , Kjeldsen Kristian , How Penelope , Bjørk Anders 
Published: December 2023

Abstract

Greenland holds more than 3300 ice-marginal lakes, serving as natural reservoirs for outflow of meltwater to the ocean. A sudden release of water can largely influence ecosystems, landscape morphology, ice dynamics and cause flood hazards. While large-scale studies of glacial lake outburst floods (GLOFs) have been conducted in many glaciated regions, Greenland remains understudied. Here we use altimetry data to provide the first-ever Greenland-wide inventory of ice-marginal lake water level changes, studying over 1100 lakes from 2003–2023, revealing a diverse range of lake behaviors. Around 60% of the lakes exhibit minimal fluctuations, while 326 lakes are actively draining, collectively contributing to 541 observed GLOFs from 2008–2022. These GLOFs vary significantly in magnitude and frequency, with the highest concentration observed in the North and North East regions. Our results show substantial annual differences in the number of GLOFs and the variations are driven by annual difference in meltwater runoff, except for the South West region. Our method detected a 1200% increase in the number of draining lakes compared to existing historical databases. This highlights a significant underreporting of GLOF events and emphasizes the pressing need for a deeper understanding of the mechanisms behind and the consequences of these dramatic events.
HPGD: an intermediate player in microglial polarization and multiple sclerosis regulated by Nr4a1
Authors: Sun Mengyang , Liu Yang , Wang Xiaowan , Wang Limei 
Published: December 2023

Abstract
Introduction
HPGD encodes 15-Hydroxyprostaglandin dehydrogenase catalyzing the decomposition of prostaglandin E2 and has not been reported in multiple sclerosis (MS). We previously found that Nr4a1 regulated microglia polarization and inhibited the progression of experimental autoimmune encephalomyelitis (EAE). Bioinformatics analysis suggested that HPGD might be regulated by Nr4a1. Therefore, this study aimed to explore the role of HPGD in microglia polarization and determine whether HPGD mediates the inhibition of EAE by Nr4a1.
Methods
C57BL/6 mice were treated with MOG35-55 peptide to induce EAE. BV-2 cells were treated with LPS/IL-4 to induce M1/M2 polarization. We then analyzed the pathological changes of spinal cord tissue, detected the expression levels of M1/M2 genes in tissues and cells, and explored the effect of HPGD on PPARγ activation to clarify the role of HPGD in EAE. The interaction between HPGD and Nr4a1 was verified by ChIP and pull-down assay.
Results
HPGD was downregulated in the spinal cord of EAE mice and HPGD overexpression alleviated the progression of EAE. Experiments in vitro and in vivo revealed that HPGD inhibited M1 polarization, promoted M2 polarization and increased PPARγ-DNA complex level. Nr4a1 could bind to the promoter of HPGD and its overexpression increased HPGD level. HPGD overexpression (or knockdown) reversed the effect of Nr4a1 knockdown (or overexpression) on M1/2 polarization.
Conclusion
HPGD is regulated by Nr4a1 and inhibits the progression of EAE through shifting the M1/M2 polarization and promoting the activation of PPARγ signaling pathway. This study provides potential targets and basis for the development of MS therapeutic drugs.
Developing an eyeball positioning method in the eye orbit for craniofacial identification in Korean population
Authors: Ryu Joon Yeol , Park Youn-Kyung , Park Ji-Hwan , Seo Jeong Uk , Roh Byung-Yoon , Kim Eui-Joo , Choi Chang-Un , Koh Kyoung Min , Lee Won-Joon 
Published: December 2023

Abstract
We analyzed the skulls and faces of Korean subjects using anthropometric methods to understand the anatomical characteristics of the eyeball and eye orbit region of Korean population and to determine the correlations between the hard and soft tissues around the eyeball and eye orbit region. In total, 82 sections in the region were measured to determine the correlations; among them, 34 showed significant differences by sex, and 6 showed significant differences by age. As the distance from the centre of the eye lens to the eye orbit is calculated as a ratio, we determined that the centre of the eye lens is located relatively on the lateral and superior position in each eye orbit in front view. Fourteen sections that could be used for craniofacial reconstruction/approximation in men and women were selected, and regression equations were derived according to the correlation of each section. Our results increase the accuracy of eyeball position determination, which would be useful for more efficient craniofacial reconstruction/approximation of the Korean population, and should improve the efficiency of facial recognition.
A novel highly divergent enteric calicivirus in a bovine calf, India
Authors: Kumar Naveen , Kaushik Rahul , Yadav Pragya , Sircar Shubhankar , Shete-Aich Anita , Singh Ashutosh , Malik Yashpal Singh 
Published: December 2023

Abstract
A novel highly divergent bovine calicivirus was identified in an Indian calf experiencing enteritis. The whole genome sequencing revealed distinct amino acid motifs in the open reading frame (ORF1) polyprotein, which are unique to caliciviruses. Phylogenetic analysis linked it with Nebovirus, a genus within the Caliciviridae family, showing only 38.5% sequence identities, emphasizing the need for separate taxonomic classification. Furthermore, in-house designed and optimized reverse transcription polymerase chain reaction (RT-PCR) assay screening of 120 archived bovine diarrhoeic fecal samples, 40 each from the Indian states of Uttar Pradesh, Haryana and Himachal Pradesh, revealed frequent circulation of these divergent caliciviruses in the Indian bovine population, with an overall positivity rate of 64.17% (77/120). This underscores the importance of conducting a comprehensive investigation into the prevalence of these divergent caliciviruses, and assessing their associations with other pathogens responsible for enteritis in India.