bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zinc Supplementation in Very Low Birth Weight Infants: A Randomized Controlled Trial
Authors: Sahin Suzan , Sari Fatma N. , Bidev Duygu , Bozkurt Ozlem , Dizdar Evrim A. , Oguz Serife S. 
Published: November 2023

Objective Preterm infants have high zinc (Zn) requirements and are generally believed to be in a negative Zn balance in the early period of life. In this study, we aimed to investigate the effect of high-dose Zn supplementation in very low birth weight (VLBW: infants with birth weight < 1.5 kg) infants on feeding intolerance and development of mortality and/or morbidities including necrotizing enterocolitis (NEC) and late-onset sepsis (LOS).
Study Design This is a prospective randomized trial. VLBW preterm infants with gestational age of <32 weeks were randomly allocated on the seventh day of life to receive extra amount of supplemental Zn along with the enteral feedings (9 + 3 mg), besides regular low-dose supplementation (3 mg), from enrollment until discharge. Outcome measures were feeding intolerance, NEC (stage ≥ 2), LOS, and mortality.
Results A total of 195 infants (97 from study group and 98 from control group) were analyzed. A total of 46 (47.4%) infants in the study group and 64 (65.3%) infants in the control group ended up with feeding intolerance (p = 0.012). NEC was observed in 11 infants (11.2%) in the control group and only 1 infant (1%) in the study group (p = 0.003). There was a negative correlation between high-dose Zn supplementation and number of culture-proven LOS episodes (p = 0.041). This significance was also present for clinical sepsis, being higher in the control group (p = 0.029). No relationship between high-dose Zn supplementation and mortality and other morbidities (hemodynamically significant patent ductus arteriosus, bronchopulmonary dysplasia, retinopathy of prematurity, and severe intraventricular hemorrhage) was observed.
Conclusion Zn supplementation for VLBW infants is found to be effective to decrease feeding intolerance, NEC, and LOS episodes in this vulnerable population. Current data support the supplementation of VLBW infants with higher than regular dose of Zn.
Key Points
Piston-cylinder cell made of Ni–Cr–Al alloy for magnetic susceptibility measurements under high pressures in pulsed high magnetic fields
Authors: Nihongi Katsuki , Kida Takanori , Narumi Yasuo , Kurita Nobuyuki , Tanaka Hidekazu , Uwatoko Yoshiya , Kindo Koichi , Hagiwara Masayuki 
Published: November 2023

We developed a metallic pressure cell made of 56Ni–40Cr–4Al (Ni–Cr–Al) alloy for use with a non-destructive pulse magnet and a magnetic susceptibility measurement apparatus with a proximity detector oscillator (PDO) in pulsed magnetic fields of up to 51 T under pressures of up to 2.1 GPa. Both the sample and sensor coil of the PDO were placed in the cell so that the magnetic signal from Ni–Cr–Al would not overlay the intrinsic magnetic susceptibility of the sample. A systematic investigation of the Joule heating originating from metallic parts of the pressure cell revealed that the increase in sample temperature is negligible at 1.4 K in magnetic fields of up to 40 T in the field-ascending process for the maximum applied magnetic field of 51 T. The effectiveness of our apparatus was demonstrated by investigating the pressure dependence of the magnetization process of the triangular-lattice antiferromagnet Ba3CoSb2O9.
Linking Sky-plane Observations of Moving Objects
Authors: Tonry John L. 
Published: November 2023

Abstract
The Asteroid Terrestrial-impact Last Alert System (ATLAS) observes the visible sky every night in search of dangerous asteroids. With four (soon five) sites ATLAS is facing new challenges for scheduling observations and linking detections to identify moving asteroids. Flexibility in coping with diverse observation sites and times of detections that can be linked is critical, as is optimization of observing time for coverage versus depth. We present new algorithms to fit orbits rapidly to sky-plane observations, and to test and link sets of detections to find the ones which belong to moving objects. The PUMA algorithm for fitting orbits to angular positions on the sky executes in about a millisecond, orders of magnitude faster than the methods currently in use by the community, without sacrifice in accuracy. The PUMA software should be generally useful to anyone who needs to test many sets of detections for consistency with a real orbit. The PUMALINK algorithm to find linkages among sets of detections has similarities to other approaches, notably HelioLinC, but it functions well at asteroid ranges of a small fraction of an astronomical unit. PUMALINK is fast enough to test 10 million possible tracklets against one another in a half hour of computer time. Candidate linkages are checked by the PUMA library to test that the detections correspond to a real orbit, even at close range, and the false alarm rate is manageable. Sky surveys that produce large numbers of detections from large numbers of exposures may find the PUMALINK software helpful. We present the results of tests of PUMALINK on three data sets which illustrate PUMALINK’s effectiveness and economy: 2 weeks of all ATLAS detections over the sky, 2 weeks of special ATLAS opposition observations with long exposure time, and 2 weeks of simulated LSST asteroid observations. Detection probabilities of linkages must be traded against false alarm rate, but a representative choice for PUMALINK might be 90% detection probability for real objects while keeping the false alarm rate below 10% for a 100:1 population of false:real. Although optimization of the tradeoffs between detection probability, execution time, and false alarm rate is application specific and beyond the scope of this paper, we provide guidance on methods to distinguish false alarms from correct linkages of real objects.
A machine-learning approach to setting optimal thresholds and its application in rolling bearing fault diagnosis
Authors: Tang Yao-Chi , Li Kuo-Hao 
Published: November 2023

Abstract
Bearings are one of the critical components of any mechanical equipment. They induce most equipment faults, and their health status directly impacts the overall performance of equipment. Therefore, effective bearing fault diagnosis is essential, as it helps maintain the equipment stability, increasing economic benefits through timely maintenance. Currently, most studies focus on extracting fault features, with limited attention to establishing fault thresholds. As a result, these thresholds are challenging to utilize in the automatic monitoring diagnosis of intelligent devices. This study employed the generalized fractal dimensions to effectively extract the feature of time-domain vibration signals of bearings. The optimal fault threshold model was developed using the receiver operating characteristic curve, which served as the baseline of exception judgment. The extracted fault threshold model was verified using two bearing operation experiments. The experimental results revealed different damaged positions and components observed in the two experiments. The same fault threshold model was obtained using the method proposed in this study, and it effectively diagnosed the abnormal states within the signals. This finding confirms the effectiveness of the diagnostic method proposed in this study.
Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts
Authors: Haider Sadia , Granell Raquel , Curtin John A , Holloway John W , Fontanella Sara , Hasan Arshad Syed , Murray Clare S , Cullinan Paul , Turner Stephen , Roberts Graham , Simpson Angela , Custovic Adnan 
Published: November 2023

Abstract

Background
Longitudinal modelling of the presence/absence of current eczema through childhood has identified similar phenotypes, but their characteristics often differ between studies.

Objectives
To demonstrate that a more comprehensive description of longitudinal pattern of symptoms may better describe trajectories than binary information on eczema presence.

Methods
We derived six multidimensional variables of eczema spells from birth to 18 years of age (including duration, temporal sequencing and the extent of persistence/recurrence). Spells were defined as consecutive observations of eczema separated by no eczema across 5 epochs in five birth cohorts: infancy (first year); early childhood (age 2–3 years); preschool/early school age (4–5 years); middle childhood (8–10 years); adolescence (14–18 years). We applied Partitioning Around Medoids clustering on these variables to derive clusters of the temporal patterns of eczema. We then investigated the stability of the clusters, within-cluster homogeneity and associated risk factors, including FLG mutations.

Results
Analysis of 7464 participants with complete data identified five clusters: (i) no eczema (51.0%); (ii) early transient eczema (21.6%); (iii) late-onset eczema (LOE; 8.1%); (iv) intermittent eczema (INT; 7.5%); and (v) persistent eczema (PE; 11.8%). There was very-high agreement between the assignment of individual children into clusters when using complete or imputed (n = 15 848) data (adjusted Rand index = 0.99; i.e. the clusters were very stable). Within-individual symptom patterns across clusters confirmed within-cluster homogeneity, with consistent patterns of symptoms among participants within each cluster and no overlap between the clusters. Clusters were characterized by differences in associations with risk factors (e.g. parental eczema was associated with all clusters apart from LOE; sensitization to inhalant allergens was associated with all clusters, with the highest risk in the PE cluster). All clusters apart from LOE were associated with FLG mutations. Of note, the strongest association was for PE [relative risk ratio (RRR) 2.70, 95% confidence interval (CI) 2.24–3.26; P &lt; 0.001] followed by INT (RRR 2.29, 95% CI 1.82–2.88; P &lt; 0.001).

Conclusions
Clustering of multidimensional variables identified stable clusters with different genetic architectures. Using multidimensional variables may capture eczema development and derive stable and internally homogeneous clusters. However, deriving homogeneous symptom clusters does not necessarily mean that these are underpinned by completely unique mechanisms.
Comparison of outcomes of azathioprine, leflunomide and allergen avoidance in patients with patch test-positive pigmented contact dermatitis: a randomized comparative study
Authors: Sinha Surabhi , Sardana Kabir , Panesar Sanjeet , Dorjay Konchok , Malhotra Purnima 
Published: November 2023

Abstract

Background
Pigmented contact dermatitis (PCD) is a noneczematous form of allergic contact dermatitis characterized by dermal hyperpigmentation. Allergen avoidance is the cornerstone of therapy, but it is difficult to achieve. The use of immunosuppressives seems rational, but data are lacking.

Objectives
To compare outcomes with azathioprine (AZA), leflunomide and allergen avoidance (AA) in patients with PCD.

Methods
A comparative study was conducted on 28 patients with patch test-positive PCD who were randomly allocated to one of three treatment groups: AZA 2 mg kg–1 daily for 24 weeks + AA (n = 10); leflunomide (LEF) 20 mg daily for 24 weeks + ­AA (n = 8); AA alone (n = 10). Patients were followed up for an additional 24 weeks. The Dermal Pigmentation Area and Severity Index (DPASI) score and Hindi Melasma Quality of Life scale (MELASQOL) were used to assess hyperpigmentation and quality of life (QoL). respectively.

Results
Hair colorants (n = 12) and paraphenylenediamine (n = 8) were the most common allergens. Mean (SD) DPASI score decreased from 30.97 (3.69), 32.35 (3.90) and 31.86 (3.47) to 13.78 (4.25), 21.67 (2.99) and 20.64 (3.82) at 48 weeks in the three groups, respectively (P &lt; 0.001); the maximum percentage decline was seen with AZA (56%). Mean (SD) MELASQOL score was reduced in the three treatment groups from 48.0 (6.46), 46.75 (3.69) and 46.6 (4.65) to 19.6 (6.98), 24.5 (5.80) and 24.0 (5.49), respectively, at 48 weeks (P &lt; 0.001). Reductions in DPASI and Hindi MELASQOL scores were significantly correlated. The most frequent adverse event was transaminitis in both the AZA and LEF groups.

Conclusions
Patients on AZA achieved a statistically significantly greater reduction in DPASI and MELASQOL score; therefore, AZA may fulfil an unmet need in PCD treatment. An objective reduction in hyperpigmentation was paralleled by an improvement in QoL score, reiterating the need for active management of this disease.
Competition Law and Policy in the Global South: Power, Coercion and Distribution
Authors: Waked Dina I 
Published: November 2023

Abstract
Countries in the Global South have adopted competition laws and pursued competition policies very similar to countries in the North. This arrangement can be traced to various coercive powers at play—from trading partners in the North, international organizations to development banks, among others. As a result, the adopted laws are often unsuitable to the local needs of the countries in the South and their enforcement policies are often shaped by global pressure. This has alienated countries in the Global South from pursuing competition enforcement policies that could be empowering to their firms, consumers and communities at large. One way to resist and challenge these coercive powers is to pursue alternative competition policies, not alien to the Western nations themselves. In these alternative configurations, competition laws are squared with goals of industrialization and distributive equality. Pursuing these alternative competition goals challenges the dominance of the static model of competition policy aiming to achieve allocative efficiency. Examples from many places around the world are illustrated to show how competition policy, at crucial times of their development, were broadened to encompass an industrial agenda. The latter, more suitable for countries in the South, is discussed as a means of counter-coercion. It is discussed alongside an elaborate program for distribution to assure that the benefits of industrialization do not befall upon only a few. The aim of such a distributive program, built into competition enforcement, is to bring social justice concerns within the purview of competition policy.
Gastroesophageal reflux disease following laparoscopic vertical sleeve gastrectomy and laparoscopic roux-en-Y gastric bypass: meta-analysis and systematic review of 5-year data
Authors: Memon Muhammed A , Osland Emma , Yunus Rossita M , Alam Khorshed , Hoque Zahirul , Khan Shahjahan 
Published: November 2023

Summary
To compare 5-year gastroesophageal reflux outcomes following Laparoscopic Vertical Sleeve Gastrectomy (LVSG) and Laparoscopic Roux-en-Y gastric bypass (LRYGB) based on high quality randomized controlled trials (RCTs). We conducted a sub-analysis of our systematic review and meta-analysis of RCTs of primary LVSG and LRYGB procedures in adults for 5-year post-operative complications (PROSPERO CRD42018112054). Electronic databases were searched from January 2015 to July 2021 for publications meeting inclusion criteria. The Hartung-Knapp-Sidik-Jonkman random effects model was utilized to estimate weighted mean differences where meta-analysis was possible. Bias and certainty of evidence was assessed using the Cochrane Risk of Bias Tool 2 and GRADE. Four RCTs were included (LVSG n = 266, LRYGB n = 259). An increase in adverse GERD outcomes were observed at 5 years postoperatively in LVSG compared to LRYGB in all outcomes considered: Overall worsened GERD, including the development de novo GERD, occurred more commonly following LVSG compared to LRYGB (OR 5.34, 95% CI 1.67 to 17.05; p = 0.02; I2 = 0%; (Moderate level of certainty); Reoperations to treat severe GERD (OR 7.22, 95% CI 0.82 to 63.63; p = 0.06; I2 = 0%; High level of certainty) and non-surgical management for worsened GERD (OR 3.42, 95% CI 1.16 to 10.05; p = 0.04; I2 = 0%; Low level of certainty) was more common in LVSG patients. LVSG is associated with the development and worsening of GERD symptoms compared to LRYGB at 5 years postoperatively leading to either introduction/increased pharmacological requirement or further surgical treatment. Appropriate patient/surgical selection is critical to minimize these postoperative risks.
Heterogeneity in parental time with children: trends by gender and education between 1961 and 2012 across 20 countries
Authors: Balbo Nicoletta , Casarico Alessandra , Sommacal Alessandro , Altintas Evrim 
Published: November 2023

Abstract
This article investigates the level and dynamics of heterogeneity in parental childcare time using data from the Multinational Time Use Study across 20 countries over five decades. Applying the Gini coefficient as the main summary measure of the dispersion in the distribution at the country level, we show that heterogeneity in paternal time has been higher than that in maternal time throughout the last half-century. The gap has narrowed over the last decade, mainly due to a reduction in paternal time heterogeneity. This pattern is observed not only across countries over time but also within those countries for which we have repeated observations. We also show relevant socio-economic variations. Heterogeneity among low-educated mothers started to be systematically above that of high-educated mothers in the 1970s. In the group of fathers, heterogeneity has always been higher for the low-educated and it has been on the rise in the last decade. Results of a counterfactual analysis suggest that the main driver of the trends in paternal timne heterogeneity is the reduction in the share of fathers who do not provide any childcare, especially among the low-educated.
Potassium intake: the Cinderella electrolyte
Authors: O’Donnell Martin , Yusuf Salim , Vogt Liffert , Mente Andrew , Messerli Franz H 
Published: November 2023

Abstract
Dietary guidelines recommend intake targets for some essential minerals, based on observational and experimental evidence relating mineral intake levels to health outcomes. For prevention of cardiovascular disease, reducing sodium intake and increasing potassium intake are the principal tools. While reducing sodium intake has received greatest public health priority, emerging evidence suggests that increasing potassium intake may be a more important target for cardiovascular prevention. Increased potassium intake reduces blood pressure and mitigates the hypertensive effects of excess sodium intake, and the recent large Phase III SSaSS trial reported that increasing potassium intake (and reducing sodium intake) in populations with low potassium intake and high sodium intake, through salt substitution (25% KCl, 75%NaCl), reduces the risk of stroke in patients at increased cardiovascular risk. As key sources of potassium intake include fruit, vegetables, nuts, and legumes, higher potassium intake may be associated with healthy dietary patterns. The current review makes the case that increasing potassium intake might represent a more advantageous dietary strategy for prevention of cardiovascular disease. Future research should focus on addressing the independent effect of potassium supplementation in populations with low or moderate potassium intake, and determine effective strategies to increase potassium intake from diet.
Disparities in donor heart acceptance between the USA and Europe: clinical implications
Authors: Wayda Brian , Angleitner Philipp , Smits Jacqueline M , van Kins Arne , Berchtold-Herz Michael , De Pauw Michel , Erasmus Michiel E , Gummert Jan , Hartyanszky Istvan , Knezevic Ivan , Laufer Guenther , Milicic Davor , Rega Filip , Schulze P Christian , van Caeneghem Olivier , Khush Kiran K , Zuckermann Andreas O 
Published: November 2023

Abstract

Background and Aims
Given limited evidence and lack of consensus on donor acceptance for heart transplant (HT), selection practices vary widely across HT centres in the USA. Similar variation likely exists on a broader scale—across countries and HT systems—but remains largely unexplored. This study characterized differences in heart donor populations and selection practices between the USA and Eurotransplant—a consortium of eight European countries—and their implications for system-wide outcomes.

Methods
Characteristics of adult reported heart donors and their utilization (the percentage of reported donors accepted for HT) were compared between Eurotransplant (n = 8714) and the USA (n = 60 882) from 2010 to 2020. Predictors of donor acceptance were identified using multivariable logistic regression. Additional analyses estimated the impact of achieving Eurotransplant-level utilization in the USA amongst donors of matched quality, using probability of acceptance as a marker of quality.

Results
Eurotransplant reported donors were older with more cardiovascular risk factors but with higher utilization than in the USA (70% vs. 44%). Donor age, smoking history, and diabetes mellitus predicted non-acceptance in the USA and, by a lesser magnitude, in Eurotransplant; donor obesity and hypertension predicted non-acceptance in the USA only. Achieving Eurotransplant-level utilization amongst the top 30%–50% of donors (by quality) would produce an additional 506–930 US HTs annually.

Conclusions
Eurotransplant countries exhibit more liberal donor heart acceptance practices than the USA. Adopting similar acceptance practices could help alleviate the scarcity of donor hearts and reduce waitlist morbidity in the USA.
Mendelian randomization for cardiovascular diseases: principles and applications
Authors: Larsson Susanna C , Butterworth Adam S , Burgess Stephen 
Published: November 2023

Abstract
Large-scale genome-wide association studies conducted over the last decade have uncovered numerous genetic variants associated with cardiometabolic traits and risk factors. These discoveries have enabled the Mendelian randomization (MR) design, which uses genetic variation as a natural experiment to improve causal inferences from observational data. By analogy with the random assignment of treatment in randomized controlled trials, the random segregation of genetic alleles when DNA is transmitted from parents to offspring at gamete formation is expected to reduce confounding in genetic associations. Mendelian randomization analyses make a set of assumptions that must hold for valid results. Provided that the assumptions are well justified for the genetic variants that are employed as instrumental variables, MR studies can inform on whether a putative risk factor likely has a causal effect on the disease or not. Mendelian randomization has been increasingly applied over recent years to predict the efficacy and safety of existing and novel drugs targeting cardiovascular risk factors and to explore the repurposing potential of available drugs. This review article describes the principles of the MR design and some applications in cardiovascular epidemiology.