bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extensive Vulvectomy and Reconstructive Flaps for Advanced Vulvar Cancer in Young Woman: Case Reports
Authors: Malik Nasdaldy , Soemanadi M , Mukarramah Dewi Aisiyah 
Published: December 2023

Introduction: : Vulvar cancer is a rare disease accounting for approximately 5% of female genital tract tumors worldwide. It is a squamous cell cancer that mostly affects older women over the age of 65. In the existing body of literature, no instances of vulvar cancer have been documented in the form of case reports. Therefore, this study aimed to report the challenges and outcomes of vulvectomy with reconstructive flap in vulvar cancer survivors in a 39-year-old woman. Case Presentation: A 39-year-old woman with a palpable lump around the vulva was present and being examined. The anatomic pathology report (APR) features suggested poorly differentiated malignant tumors. A neoadjuvant chemotherapy was then administered to the patient aimed at shrinking the size of the tumor. However, there was no effective response to the chemotherapy, which resulted in a progressive tumor. Extensive vulvectomy and reconstructive flap were carried out to support quality of life, and the outcomes were reported, including flap, survival, complications, and mortality. These outcomes were evaluated between November 2021 and March 2023. No total flap loss was observed, and neither was there any donor site morbidity or mortality during the process. Conclusions: This study showed that vulvar cancer was a rare condition at a young age. Advanced vulvar cancer was found in the patients and extensive vulvectomy surgery was carried out followed by a pedicled ALT flap. This option was currently the best for immediate reconstruction due to the preservation of sensibility and tissue availability in the donor areas. The result showed no wound dehiscence, marginal necrosis, or surgical site infection. After 15 months of follow-up, the flap was observed to have good vascularization. The association of the Gynecologist with the Plastic Surgeon offered palliative care to improve the quality of life of the patient and provide good postoperative results.
BRAF V600E Mutation Test in Fine Needle Aspiration (FNA) Specimens of Thyroid Nodules by Competitive Allele-Specific TaqMan PCR (castPCR)
Authors: Perdana Adhitya Bayu , Adisasmita Asri C , Putri Rizky Ifandriani , Brahma Bayu 
Published: December 2023

Background: BRAF V600E mutation has been confirmed as a significant molecular indicator for the diagnosis and prognosis of papillary thyroid carcinoma (PTC). Sanger sequencing is the recognized approach for BRAF V600E mutation analysis, yet it is not proficient at detecting mutations that occur at low frequencies, especially in thyroid fine needle aspiration (FNA) specimens. This study aimed to evaluate the diagnostic value of Competitive Allele-Specific TaqMan PCR (castPCR) as a new reliable method for BRAF V600E mutation test in thyroid FNA specimens compared to Sanger sequencing. Methods: Thirty patients with thyroid nodules were enrolled prospectively at Dharmais Cancer Hospital Jakarta from 2013–2014. The BRAF V600E mutation was analyzed from FNA specimens using castPCR and Sanger Sequencing methods. The sensitivity and specificity of those methods were compared with routine diagnostic histopathological examination as a gold standard for PTC assessment.Results: A total of 66.6% (20/30) cases were confirmed as PTC by postsurgical histopathological examination. Among these, the BRAF V600E mutation was found in 60.0% (12/20) by castPCR and 40.0% (8/20) by Sanger sequencing. Neither castPCR nor Sanger sequencing detected BRAF V600E mutation in other nodular thyroid diseases. The sensitivity and specificity of castPCR were 60.0% and 100.0%, while Sanger sequencing was 40.0% and 100.0%, respectively. Conclusions: This study indicated that castPCR has a higher sensitivity for the BRAF V600E mutation test than Sanger Sequencing, especially in samples with a low abundance of mutant alleles. A sensitive, rapid, and easy castPCR method is reliable for evaluating BRAF V600E mutation and can improve PTC preoperative diagnosis in clinical settings.
Recent Technological Advancements in Respiratory Gating Devices
Authors: Muhamadi Amar Ma’ruf Irfan , Sudarmaji Arief , Pawiro Supriyanto Ardjo 
Published: December 2023

Background: The occurrence of motion in the thoracoabdominal region during radiotherapy treatment is an inherent challenge affecting the accuracy of the radiation beam. To address this challenge, a margin is often incorporated to compensate for the motion, but it has been reported to have several limitations. Consequently, respiratory gating has emerged as an integrated feature within radiotherapy-related machines. This innovative approach is designed to overcome motion-related challenges, leading to a reduction in the required margin and an improvement in the accuracy of the radiation beam. Methods: This study reviews the literature published in English between 2012 to 2021 regarding breathing monitoring devices used in the clinical or research stage. Furthermore, articles published before 2000 were traced to strengthen the theories. Results: Several monitoring devices had been reported to have respiratory gating purposes, but some were not equipped for this function. Furthermore, these devices were often developed using non-contact equipment, such as lasers and cameras, to provide accurate and precise measurements. One of their key advantages is the lack of physical attachment to the patients, thereby preserving comfort. The development of respiratory gating devices had significant potential to enhance the quality of radiotherapy treatment. This was manifested through more effective tumor and organ treatment and reduced toxicity. These benefits had the potential to extend the life expectancy of patients with respiratory-related cancer. Conclusions: Based on the results, respiratory gating was an advantageous technique in radiotherapy treatment. The development of respiratory gating devices enhanced patient comfort and the effectiveness of treatment.
Call for Abstracts
Authors: CJAR  
Published: December 2023

The Action Research Network of the Americas (ARNA) in partnership with Yellowhead Tribal College (YTC), Edmonton, Alberta, Canada.
ARNA and YTC are very pleased to announce that YTC will host ARNA’s 11th Annual Conference as a hybrid event from May 30 – June 2, 2023 at the Yellowhead Tribal College in Edmonton, Alberta, Canada. The Call for Abstracts includes both ARNA’s traditional conference topics as well as a range of topics focused on this year’s theme: Land-Based Knowledge and Action Research. The deadline for abstract submissions is March 13, 2023.
Please see the attached PDF for details.
Call for Submissions for Special Issue focused on School Community Health and Wellness
Authors: CJAR  
Published: December 2023

The Canadian Journal of Action Research (CJAR) and the Canadian Association of Action Research in Education (CAARE) are inviting manuscripts for a special themed issue that will focus on school community health and wellness, and/or related disciplines such as physical education, health education, physical activity, sport, recreation, play, outdoor learning, social determinants of health, mental health literacy, and comprehensive school health/health promoting schools.
Manuscript proposals are due June 15, 2023. Authors should send working title, abstract, and author bio to Managing Editor, Marianne Barker (Marianne.barker@mail.mcgill.ca) for editorial approval.
Full final manuscripts are due December 15, 2023.
PAR Trailblazers & Good Troublemakers Podcast: Season 2, Episode 2
Authors: Maguire Patricia 
Published: December 2023

Season 2, Episode 2 of the PAR Trailblazers & Good Troublemakers podcast was published on October 1, 2023. The title of the episode is "Nurturing Relational Action Research Enclaves." In this episode, Mary Brydon-Miller and Miriam Raider-Roth discuss building relational enclaves for AR by bringing feminist values and ways of being to PAR and practitioner inquiry.
Listen here.
Eﬀectiveness of Manipulative Therapy on Neck Pain, Function and Disability. A Systematic Review
Authors: Xu Nan , Surucu Elif Nur 
Published: December 2023

Background: Neck pain is a common musculoskeletal issue affecting people worldwide, and manipulative therapy is implemented as a treatment for it.
Aim: To analyse the effects of different manipulative therapy techniques on the pain intensity, sensitivity and function in patients with neck pain.
Methods. Studies between 2012 - April 2022 were selected to investigate the effectiveness of manipulative therapy on neck pain, function and disability. The databases PubMed ®, CNKI, Science Direct, Springer LINK, ResearchGate, Semantic Scholar, Taylor & Francis Online and Google Scholar were utilised. The selection criteria included studies involving human subjects with neck musculoskeletal pain, focusing on the effects of manipulative therapy on neck pain management and function.
Results: 10 studies with 573 subjects were included. Strong evidence supported that manipulative therapy was effective in reducing pain and increasing the pain threshold and the function of the neck. A significant (p<0.05) positive effect was reported by 100% of studies that implemented the above parameters. Moderate evidence showed that manipulative therapy was effective in the management of the disability of the neck. The ratio of positive effect was 66.66% among involved studies with very significant results (p<0.01). Moderate evidence with a limited amount of study showed a significant increase in muscle strength after manipulative therapy (p<0.05).
Conclusions. Manipulative therapy is effective in reducing neck pain intensity and sensitivity as well as improving neck function and reducing disability. The combined application of manipulative therapy is always more effective than the isolated application of manipulative therapy on patients with neck pain.
Keywords: Neck pain; manipulative therapy; effectiveness; pain threshold; pain intensity; neck function
EFFECT OF POLYMER MODIFIER ON THE MOR­PHO­LOGICAL AND SEPARATION PROPERTIES OF ASYMMETRIC MICROFILTRATION MEMBRANES
Authors: Magalhaes-Ghiotto Grace , Molina Luiza , Kudelko Kateryna , Nichi Leticia , Bergamasco Rosangela , Dzyazko Yuliya 
Published: December 2023

Modifying membranes is a common approach to improve their separation ability. In this work, a series of the membranes, which reject colloidal particles of a wide diapason of their size, was obtained by modifying acetylcellulose microfiltration membranes with such rigid polymer as polymetylmetacrilate. Modifying was carried out by precipitation of the polymer in the membrane pores, the depo­sition occurred from the solutions of different concentrations. Other way was multistage modifying membranes with a solution of the same concentration. Depending on the modifying conditions, the content of polymetylmetacrilate in the membrane was 12–44 %. Morphology of the composite membranes was investigated by optical and scanning electron microscopy. Water test was also performed at 0.5–2 bar. The membranes obey Darcy law in this pressure diapason: thus, the pore radius can be approximately estimated from the Hagen – Poiseuille equation (18–63 nm). Moreover, the modifier minimizes the membrane compression: a decrease of the permeate flux is 19 % (pristine membrane) and 8% for membranes containing high amount of the modifier. Colloidal solutions of water-soluble linear polymer, vegetable protein and sol of hydrated iron oxide were also used for the membrane testing. The selectivity of composite membranes enhances in the row: polyvinylpyrollidone < iron oxide < albumin. In the case of vegetable protein, the membrane selectivity is 30–91% depending on the modifier content. The membrane with highest separation ability was used for clarification of goiaba juice: the selectivity towards total solids was found to reach 33–73%. The permeate can be used for the production of beverages, the concentrate is recommended for confectionery industry. Polymethylmetacrylate can be recommended for the membrane modifying as a binding component in the composite containing also hydrophilic agent.
PERANAN FILSAFAT PENDIDIKAN DALAM PEMBENTUKAN MORALITAS SISWA
Authors: Fahira Wina Roza , Sari Yesi Guspita , Putra Bera Eka , Setiawati Merika 
Published: December 2023

Filsafat merupakan hal yang penting dalam Pendidikan. Maka Pendidikan tidak terlepas dari akhlak para siswa. Pendidikan moral adalah pendidikan yang menerapkan prinsip integritas dengan pendekatan akhlak atau akhlak. Penelitian ini bertujuan untuk mengetahui peranan filsafat pendidikan dalam pembentukan moralitas siswa. Di sini akan dibahas apa kaitan filsafat, pendidikan dan moral. Kemudian bagaimana pendidikan membentuk manusia lalu apa sebab timbulnya krisis moral pada siswa serta apa solusi dalam mengatasi krisis moral tersebut. Metode yang digunakan adalah literatur review jurnal yaitu sebuah pencarian literatur baik internasional maupun nasional yang dilakukan dengan menggunakan Google cendiakia, science direct dan proquest. Hasil dari penelitian ini adalah Untuk berhasilnya output dari proses pendidikan diperlukan terciptanya manusia yang bermoral. sehingganya pendidikan moral sangat diperlukan bagi kehidupan manusia karena dengan melalui pendidikan, perkembangan moral diharapkan dapat berjalan dengan baik, serasi, sesuai dengan norma, harkat martabat dan nilai-nilai manusia itu sendiri. Disimpulkan bahwa filsafat sangat berkaitan dengan pendidikan dan moral, peran orang tua dan guru sangat dibutuhkan dalam membentuk moral serta mengatasi Krisis moral pada siswa.
HAKIKAT PESERA DIDIK DALAM PERSPEKTIF FILSAFAT PENDIDIKAN
Authors: Nurhidayati Voni , Ramadani Fitri , Melisa Fika , Setiawati Merika 
Published: December 2023

Didalam pendidikan banyak pandangan yang mengesensikan peserta didik salah satunya filsafat pendidikan. Pada penulisan artikel ini penulis menggunakan metode literature review. Dimana metode ini berisi ulasan, rangkuman, dan pemikiran penulis tentang beberapa sumber pustaka. Literatur review adalah sebuah metode yang sistematis, eksplisit dan reprodusibel untuk melakukan identifikasi, evaluasi dan sintesis terhadap karya-karya hasil penelitian dan hasil pemikiran yang sudah dihasilkan oleh para peneliti dan praktisi. Tujuan dari pembuatan artikel ini untuk mengetahui bagaimana hakikat peserta didik ini dalam pandangan atau perspektif filsafat pendidikan. Berdasarkan analisis yang dilakukan dalam hakikat peserta didik dalam perspektif filsafat pendidikan, maka dapat disimpulkan bahwa peserta didik merupakan seluruh makhluk yang secara khusus beriorientasi pada manusia. Dalam hakikatnya melekat pada tiap-tiap diri manusia sebagai individual yang memerlukan pendidikan agar dapat memelihara diri baik itu fisik maupun psikis, meraih ilmu dan menuntutnya untuk meneguhkan diri peserta didik serta mengaktualisasikannya. Peserta didik juga merupakan sasaran pendidikan maka peserta didik sebagai subjek yang berperan sangat aktif dan difasilitasi oleh sumber belajar termasuk pendidik. Didalam perspektif filsafat pendidikan islam pendidik dan peserta didik diartikan sebagai mekanisme dalam berpikir secara logis,kritis serta sistematis dalam seluruh kenyataan yang ada dan yang barangkali menjadi sikap dan keyakinan yang besar oleh subjeknya.
Sejarah Dan Manajemen Pendidikan Di Suriah
Authors: Kamus Kamus , Hasaruddin Hasaruddin , Sari Yuni Purnama 
Published: December 2023

Suriah merupakan salah satu negara Arab yang menjadi saksi perkembangan sejarah dan pendidikan Islam. Syam atau dikenal juga dengan nama Syam adalah negeri yang pernah dikunjungi Nabi SAW dalam perjalanan bisnisnya. Tujuan artikel ini adalah untuk mengetahui prioritas Suriah dari sudut pandang Islam, sejarah Suriah dan konflik konfliknya saat ini, serta gambaran konflik Suriah. Dari hasil penulisan artikel ini, saya mengetahui bahwa Suriah pernah menjadi pusat peradaban tertua di dunia. Suriah memiliki kelebihan dalam sudut pandang Islam, seperti menjadi tempat kelahiran nabi dan rasul, kota tujuan nabi, para malaikat melebarkan sayapnya di Suriah, dan tempat nabi berdoa memohon keberkahan. Masa kekhalifahan Abu Bakar asy-Siddiq relatif singkat, dan di bawah kekhalifahan Umar bin Khattab, Islam menyerbu Suriah di bawah komando Khalid bin al-Walid dan berhasil mengalahkan musuh di Marjah Shafar. Utsman bin Affan tewas secara tragis di tangan pemberontak dan pembangkang. Ali bin Abi Thalib mendapat tekanan dari para pendukungnya untuk segera menggantikan Utsman bin Affan sebagai khalifah keempat. Semoga artikel ini bermanfaat bagi Anda untuk menulis artikel selanjutnya.
Hubungan Islam Dan Kristen Pada Abad Pertengahan
Authors: Nasir Muh , Hasaruddin Hasaruddin 
Published: December 2023

Penelitian ini bertujuan untuk menjelaskan periodenisasi hubungan Islam dan Kristen di Abad Pertengahan. Periode abad pertengahan dalam sejarah adalah masa dalam kurun waktu antara tahun 1250-1800. Di masa ini, termasuk masa kemunduran dunia Islam. Periode sejarah Islam pada umumnya dibagi dalam tiga periode. Periode pertama adalah periode klasik pada tahun pada tahun 650-1250 M yang dibagi dalam dua fase; fa-se ekspansi, integrasi, dan puncak kemajuan pada tahun 650-1000 M dan fase disin-tegrasi pada tahun 1000-1250 M. Periode kedua adalah periode pertengahan pada ta-hun 1250-1800 M yang dibagi dalam dua fase; fase kemunduran pada tahun 1250-1500 M dan fase tiga kerajaan besar pada tahun 1500-1800M. Periode ketiga adalah periode modern pada tahun 1800-sekarang yang merupakan zaman kebangkitan umat Islam. Hubungan Kristen dan Islam bermula di awal abad pertengahan melalui kontak perang yang disebut "Perang Salib", dan penyerbuan bangsa Mongol ke wilayah-wilayah Islam. Melalui perang tersebut, orang-orang Kristen memasuki wilayah-wilayah yang dikuasai Islam. Setelah itu, orang-orang Kristen mulai mempelajari ilmu-ilmu keislaman, sehingga mereka mengalami kemajuan. Di saat yang sama justru orang-orang Islam mengalami kemunduran, dan ketika tiga kerajaan mulai mundur, secara cepat bangsa Kristen menguasai kaum muslim. Kristen Eropa memanfaatkan kemajuan ilmu pengetahuan Islam untuk mentransfernya lalu dibawanya ke dunia Eropa. Di samping itu, di Spanyol terjadi perebutan kekuasaan oleh Kristen dari tangan Islam yang pada akhirnya melenyapkan Islam di Spanyol. Namun demikian, hubungan harmonis antara Kristen dan Islam tetap tampak di Kerajaan Turki Usmani karena dikembangkan-nya politik toleransi. Keadaan tersebut berlangsung sampai pada awal abad XIX. Hubungan Islam dan Kristen terganggu kembali akibat muncul kekerasan imperalisme Barat di sejumlah negara-negara Islam.
Komunikasi Sains Peserta Didik Melalui Pembelajaran Argument Driven Inquiry Berbantuan Argument Mapping Pada Konsep Pencemaran Lingkungan
Authors: Wahyudin Siti Nur Azizah , Windyariani Sistiana , Juhanda Aa 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui signifikansi dari pengaruh model Argument Driven Inquiry berbantuan Argument Mapping terhadap komunikasi sains peserta didik dalam konsep materi pencemaran lingkungan, dengan urgensinya karena besarnya tuntutan di abad 21 untuk memiliki keterampilan yang mumpuni yaitu kemampuan berkomunikasi (Communication), berkolaborasi (Collaboration), berpikir kritis (Critical Thingking) dan kreatif (Creativity) yang perlu dibekalkan kepada peserta didik untuk menghadapi era global. Populasi penelitian ini adalah seluruh peserta didik kelas VII MTs Nurul Huda (YASPIN) Tahun ajaran 2022/2023 dengan sampel penelitian di VII B. sejumlah 21 orang dengan metode penelitian pra-eksperimental. Instrumen penelitian yang digunakan yaitu soal uraian sebanyak 7 soal dan lembar skala sikap. Data penelitian diuji secara parametric menggunakan uji normalitas dan homogenitas dan terakhir hipotesis penelitian menggunakan normalitas dan hasil penelitian ini menunjukkan bahwa model Argument Driven Inquiry terhadap kemampuan komunikasi sains nilai rata-rata tertinggi yaitu kadar pengetahuan (content knowledge) dan nilai terkecil yaitu kategori kognitif (cognitive categories).
Pengembangan Media Pembelajaran Berbasis 3D Printing Mata Kuliah Biologi Sel
Authors: Syam Sukmawati , Anshori Fitrah Al , Alfat Nurul 
Published: December 2023

Penelitian ini bertujuan untuk mengembangkan media pembelajaran biologi sel berbasis 3D printing. Masalah pembelajaran biologi sel yang dialami oleh pengajar yaitu kurangnya model pembelajaran yang kuat, praktis dan mudah diamati. Selama ini media pembelajaran yang digunakan di kelas berasal dari media animasi, gambar dan media contoh yang sederhana. Hal ini menimbulkan masalah dalam transfer pengetahuan karena sifat materinya yang abstrak maka perlu media pembelajaran yang bersifat realia dan awet agar dapat digunakan kapan saja. Metode penelitian yang digunakan yaitu Research and Development, model pengembangan menggunakan jenis ADDIE. Subjek penelitian ini merupakan mahasiswa dan dosen pendidikan biologi Universitas Cokroaminoto Palopo yang memprogram mata kuliah biologi sel. Hasil penelitian berupa skor kevalidan sebesar 89%, skor kepraktisan bagi pengajar sebesar 84% dan kepraktisan bagi mahasiswa sebesar 80%. Model 3D printing yang dikembangkan yaitu sel hewan, sel tumbuhan, mitokondria, membran sel.
Analisis Keterampilan Berpikir Kritis Siswa Pada Bidang Studi Biologi Materi Virus Kelas X IPA MAN 1 Polewali Mandar
Authors: Mukrimah Mukrimah , Syamsiah Syamsiah , Lodang Hamka 
Published: December 2023

Penelitian ini bertujuan untuk mengetahui tingkat keterampilan berpikir kritis siswa pada bidang studi biologi materi virus kelas X IPA MAN 1 Polewali Mandar. Jenis penelitian ini adalah penelitian deskriptif dengan menggunakan metode survey. Populasi penelitian ini sebanyak 4 kelas X IPA dengan jumlah siswa sebanyak 159 dan sampel sebanyak 114 siswa diperoleh dengan menggunakan rumus Slovin teknik simple random sampling. Data keterampilan berpikir kritis dikumpulkan dengan menggunakan tes berupa soal uraian (essay) kemudian dianalisis menggunakan bantuan Microsoft Office Excel. Hasil analisis menunjukkan indikator keterampilan berpikir kritis menurut Departemen Pendidikan Nasional (2008) yaitu memfokuskan pertanyaan mendapatkan nilai persentase 49,78% dengan kategori sedang, menganalisis argumen mendapatkan nilai persentase 52,63% dengan kategori sedang, mempertimbangkan keterampilan induksi mendapatkan nilai persentase 42,53% dengan kategori sedang, mendefinisikan konsep mendapatkan nilai persentase 41,55% dengan kategori sedang dan mendeskripsikan mendapatkan nilai persentase 60,08% dengan kategori tinggi dengan total rata-rata persentasenya yaitu 49,3%. Berdasarkan hasil penelitian dapat disimpulkan bahwa keterampilan berpikir kritis siswa pada bidang studi biologi materi virus kelas X IPA MAN 1 Polewali Mandar berada pada kategori sedang.