bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifocal Tuberculous Osteomyelitis of Ribs with Active Pulmonary Infection
Authors: Elumalai Venkatesh , Krishnamoorthy K. , Pratheeban T. Joseph , Mathan E. , Hameed O. M. Rahman Shahul 
Published: January 2025

Abstract
Skeletal tuberculosis (TB) is a type of extrapulmonary TB affecting bony structures. Surprisingly, rib involvement is rare, comprising only 0%–5% of bone TB cases. Multifocal tuberculous osteomyelitis of the rib is a very rare condition, affecting only 0.1% of individuals with TB. We present here the case of a 28-year-old male who is an accountant in a travel agency with no comorbidities presented with complaints of cough with expectoration and swelling over the left posterolateral chest wall for 3 months’ duration. Imaging by computed tomography and magnetic resonance imaging of the chest showed features of multifocal tuberculous osteomyelitis of ribs with active pulmonary TB. Pus was aspirated from chest wall swelling detected mycobacterium TB in Catridge based nucleic acid amplification test, and the patient was started on antitubercular therapy. This case emphasizes skeletal TB, despite being the prevalent form of extrapulmonary TB, and presents an intriguing aspect with rib involvement remaining a relatively rare phenomenon.
Comparative evaluation of two different doses of nebulized intraperitoneal dexamethasone on postoperative pain in laparoscopic surgeries
Authors: Shrivastava Neha , Taneja Rashmi , Kumari Mamta , Sood Rajesh , Grover Niharika 
Published: January 2025

Abstract

Background and Aims:
Postoperative pain is a major cause of discomfort after laparoscopic surgeries and thus necessitates prevention and treatment. This study aims to evaluate and compare two different doses of intraperitoneally nebulized (aerosol size: 0.4–4.5 micrometers) dexamethasone for the prevention of postoperative pain.

Material and Methods:
In this double-blind, randomized control study, 135 patients undergoing laparoscopic surgeries were randomly assigned to three groups after obtaining ethical committee clearance and CTRI registration. Intraperitoneal nebulization was performed using the Aeroneb device, with group A receiving 16 mg dexamethasone, group B receiving 8 mg dexamethasone, and group C receiving 0.9% normal saline. The primary outcome was assessed by measuring visceral, somatic, and referred pain using a visual analog scale (VAS) at 6 hours postoperatively. Secondary outcomes included VAS at 1 and 24 hours, the hemodynamic response to pneumo-peritoneum, 24-hour anti-emetics, and opioid consumption.

Results:
VAS score at 6 hours was 0.9 ± 1.06 in group A, 1.7 ± 1.45 in group B, and 2.3 ± 1.87 in group C for referred pain; the values were statistically significant (P = 0.01). VAS score was 0.7 ± 0.76 in group A, 1.7 ± 1.82 in group B, and 2.2 ± 2.06 in group C for dull aching pain; the results were statistically significant at 24 hours (P = 0.001). None of the values at any time point were statistically significant (P < 0.05) for incisional pain. The rise in heart rate after 5 minutes of pneumoperitoneum was the least in group A compared to group C (P = 0.01). Group C had the highest consumption of anti-emetics and rescue analgesics (P = 0.001).

Conclusions:
Intraperitoneal dexamethasone nebulization of 16 mg and 8 mg both are equi-effective in decreasing the severity of pain after laparoscopic surgeries compared to normal saline nebulization (P = 0.001).
The “Weekend Effect” and “Off-Hours Effect” in Pediatric TBI: An Observational Study From the High-Income Developing Country—Sultanate of Oman
Authors: Al-Rahbi Adham , Al-Farsi Aws , Al-Shibli Rashid , Al-Kalbani Salim , Al-Saadi Tariq 
Published: January 2025

Abstract

Background:
Traumatic brain injuries (TBIs) are the leading cause of death and disability in children. The concern about care quality difference between weekdays and weekends is increasing.

Aim:
This study compares the outcome of TBIs in pediatrics during weekdays versus weekends.

Materials and Methods:
This is a retrospective cohort study conducted from January 2015 to December 2020 involving 98 patients from Khoula Hospital. The primary outcome was death, which is defined as deaths during the index hospitalization and/or deaths within 30 days. The need for surgical intervention is another outcome. We considered the difference in outcomes between working hours and off-hours in the same patients. Binary regression analysis was used to identify risk factors associated with pediatric TBI mortality based on arrival time.

Results:
All 98 patients were discharged from the hospital with no mortality. Additionally, all our patients had surgical intervention during their hospital stay. A higher number of males presented during weekdays (73.4%), while a higher number of females presented during weekends (63.2%; P < 0.05, OR = 0.282). The number of patients presenting during weekdays (80.6%) was higher than those presenting during weekends (19.3%). In addition, the number of patients presenting during off-hours (39.7%) was higher than that of patients presenting during working hours (60.2%; P < 0.05). Patients presenting during off-hours were likely to have surgeries lasting <120 min (P < 0.05).

Conclusion:
No association was found between weekend/off-hour effects and pediatric TBI outcomes. Currently, there are no existing studies that highlight this effect on pediatric TBI. Therefore, this study is the first study investigating the difference in outcomes between weekdays and weekends in pediatric TBI cases.
Assessment of Fastigial Angle in Fetuses with Blake Pouch Cyst and Vermian Hypoplasia on Magnetic Resonance Imaging
Authors: Murali Lokesh , Rangasami Rajeswaran , Priyanka Chandrasekhar , Suresh Indrani , Suresh Sudarshan 
Published: January 2025

Abstract

Objective:
To obtain the fastigial angle in fetuses with Blake pouch cyst (BPC) and vermian hypoplasia (VH) on magnetic resonance imaging (MRI).

Materials and Methods:
A total of 39 patients (13 cases of BPC, 13 cases of VH, and 13 normal controls) referred for fetal MRI from June 2020 to April 2023 were retrospectively analyzed. The gestational age at MRI examination was between 21 and 24 weeks. The MRI images were reviewed independently by two senior neuroradiologists, and the final findings were arrived in consensus. The fastigial angles were measured in fetuses with BPC and VH. The results were statistically analyzed and compared with control groups.

Results:
The fastigial angles were significantly increased/more obtuse in VH (134.0 to 154.0°) (mean ± 2SD) compared to BPC (95.0 to 129.8°) (mean ± 2SD) in our study. The brainstem vermian angle ranged from 22.3 to 30.3° (mean ± 2SD) in BPC and 31.5 to 47.5° (mean ± 2SD) in VH, respectively, in our study.

Conclusion:
Fastigial angle measurement is a complementary tool for the accurate diagnosis of posterior fossa malformations, such as BPC and VH, on fetal MRI
Revista Científica Yachaq Vol. 7 N° 1, Enero – Junio, 2024
Authors: Editorial Fondo 
Published: January 2025

REVISTA CIENTÍFICA YACHAQ
La Revista YACHAQ, creada en el año 2018, es una publicación científica semestral (enero-junio, julio-diciembre) editada por la Universidad Católica de Trujillo Benedicto XVI, a través del Vicerrectorado de Investigación y la Facultad de Ciencias Administrativas y Económicas, tiene como propósito la divulgación y promoción del conocimiento en las Ciencias Sociales, especialmente en los temas de administración, negocios, economía, derecho y psicología jurídica. La Revista está dirigida a investigadores nacionales e internacionales para la discusión, investigación y reflexión mediante la publicación de artículos originales e inéditos en secciones como: investigaciones originales, ensayos y artículos de revisión. Los manuscritos recibidos para la revista YACHAQ son evaluados por árbitros externos e internos bajo un sistema de arbitraje doble ciego, según criterios de originalidad, cumplimiento de las normas editoriales y contribución al conocimiento científico, tecnológico y de innovación. YACHAQ se adhiere a los principios de acceso abierto, así mismo, la revista no tiene ningún costo para los autores por sometimiento, ni por publicación, al ser financiada totalmente por la Institución editora.
La Universidad UCT autoriza la reproducción de los manuscristos, siempre que se identifique su procedencia. Los artículos que aparecen en esta Revista Científica expresan las opiniones personales de sus autores.
Analisis Pengaruh Variabel Ekonomi Makro dan Sektoral Terhadap Kinerja Saham Terbaik Jakarta Islamic Indeks (JII) Periode 2021-2023
Authors: W Famita Wibi , F Rico Dwi , H Latifah Sekar , P Veronica Amelya , Hibatullah Fausania 
Published: January 2025

Negara Indonesia merupakan negara dengan penduduknya mayoritas beragama islam. Menurut data Direktorat Jenderal Kependudukan dan Pencatatan Sipil (Ditjen Dukcapil) Kementrian Dalam Negeri (Kemendagri), jumlah penduduk Indonesia yang beragama islam pada semester I tahun 2024 adalah 245,973,915 jiwa atau setara dengan 87,08% dari total populasi Indonesia. Dalam berinvestasi, agama islam diajarkan untuk berinvestasi sesuai dengan prinsip syariah khususnya pada produk investasi saham. Jakarta Islamic Index atau JII merupakan indeks saham yang terdiri dari kumpulan saham perusahaan yang sesuai dengan prinsip syariah. Sehingga masyarakat negara Indonesia tidak perlu khawatir dalam berinvestasi, karena JII hadir untuk memudahkan umat islam di Indonesia dalam berinvestasi. Selain itu, saham yang terdapat pada indeks JII merupakan saham dengan Perusahaan yang kuat dan memiliki fundamental yang baiik. Pada penelitian ini mendapatkan hasil bahwa klaster dan emiten yang terpilih merupakan klister 1 dan emiten BRMS, TPIA, dan ADRO. Akan tetapi pada analisis TPIA tidak terpenuhi, maka diganti dengan emiten BRPT. Ketiga saham tersebut menunjukkan adanya kemungkinan fluktuasi dalam nilai investasi dan pada uji stationeritas ketiga saham tersebut menunjukkan bahwa semua variable makro dan sectoral tidak stationer pada turunan level, namun stationer pada turunan pertama. Estimasi model jangka pendek dengan nilai ECT pada ketiga saham tersebut menunjukkan terpenuhi dan tidak memiliki pengaruh pada jangka pendek. Pada peramalan menggunakan metode peramalan, hasil analisis ketiga saham tersebut menunjukkan bahwa mmodel terbaik terdapat pada Single Exponential Smoothing dengan nilai alpha sebesar 0,7.
Українська тематика у публіцистичній спадщині Антанаса Сметони (1874-1944)
Authors: Петрик А.М. 
Published: January 2025

Дана стаття фокусується на інтелектуальній спадщині видатного литовського політичного і державного діяча Антанаса Сметони. Першого президента демократичної Литви у 1919–1920 рр. Автократичного керівника Литовської держави у 1926–1940 рр. Окрім політичної діяльності ця особистість є знаковою у громадському і культурному сегменті литовського національного руху доби пізнього етапу національного відродження. А. Сметона вів активну видавничу та редакторську роботу у царині литовськомовних засобів масової інформації. Організовував ефективне продукування просвітницького контенту для литовського читача. Окрім цього, майбутній президент залишив по собі значний масив публіцистичного матеріалу. «Українське питання» кидало відблиск на обидві вищезазначені іпостасі А. Сметони – політика та інтелектуала. Україна, з її минулим та сучасним, перебувала у сфері його зацікавлень від раннього етапу творчої діяльності на початку ХХ ст. Так само давньою була комунікація з українськими інтелектуальними елітами. Роки революції та збройної визвольної боротьби трансформували старі зв’язки, перевели їх на нову платформу. Керована А. Сметоною Литва надавала підтримку українським революційно-визвольним структурам протягом 1920–1930-х рр. Ця підтримка ґрунтувалася на стратегічних литовських інтересах, втім, базувалася і на фундаменті обізнаності литовського національного лідера у реаліях України та її народу.
У нашій роботі ми торкнемося малодослідженої складової публіцистичного продукту А. Сметони, а саме української тематики в його інтелектуальному доробку. Робота фокусується на багатоскладовій цілі – заповнені лакун у студіях української історичної литуаністики та балтистики у контексті новітньої доби, а також відтворення деяких невисвітлених донині аспектів українсько-литовських відносин ХХ ст. Це здійснюється через аналіз творчої спадщини А. Сметони. Особливу увагу нами приділено його знаковим публіцистичним творінням українознавчого спрямування.
Analisis Proses Rekrutmen Kelompok Penyelenggara Pemungutan Suara (KPPS) Pemilu Tahun 2024 Di Kecamatan Dolok Kabupaten Padang Lawas Utara
Authors: Imam Pujima Jailani Hasibuan  , M. Fachri Adnan  
Published: January 2025

Penelitian ini dilatarbelakangi banyaknya ditemukan anggota KPPS yang tidak mengerti dengan tugasnya ,tidak melaksanakan sesuai tupoksi dan banyak juga ditemukan anggota KPPS yang tidak melek teknologi sehingga banyak terjadi kesalahan pada saat pelaksanaan pemilu 2024 dikecamatan Dolol. Penelitian ini bertujuan menganalisis terkait permasalahan proses rekrutmen anggota KPPS yang dilakukan oleh PPS pada pemilu 2024 di Kecamatan Dolok Kabupaten Padang Lawas Utara. Penelitian ini menggunakan pendekatan kualitatif deskriptif, di mana data diperoleh melalui wawancara mendalam dan studi dokumentasi. Uji keabsahan data digunakan tehnik triangualasi. Data penelitian dianalisis dengan model tradisi analisis kualitatif yaitu tradisi Manual Data Analysis Procedure (MDAP). Hasil penelitian menunjukkan bahwa Proses Rekrutmen Anggota Kelompok Penyelenggara Pemungutan Suara (KPPS) menggunakan tiga tahapan yaitu tahap sourcing process, tahap selection process, dan tahap user process. Terdapat beberapa permasalahan dalam proses rekrutmen angggota kpps yaitu distribusi informasi rekrutmen belum merata, Pelatihan dan simulasi yang diberikan kepada anggota KPPS di Kabupaten Padang Lawas Utara belum optimal, dan Proses seleksi dan pelatihan kurang transparan, terutama dalam hal pemantauan oleh pihak independen.
Subsidi Energi: Tantangan Penyaluran BBM, LPG 3 kg, serta Dukungan Terhadap Kendaraan Listrik
Authors: A’yun Qurrata , Akhmadi Muhammad Heru , Wati Erlita Nurma 
Published: January 2025

Energi hijau menjadi strategi dalam mengendalikan perubahan iklim secara global. Beberapa negera termasuk Indonesia telah mendorong pertumbuhan energi hijau dengan mengendalikan penggunaan energi fosil dengan tetap memperhatikan kebijakan pembangunan yang dapat memberikan multiplier effect terhadap pertumbuhan ekonomi. Penelitian ini bertujuan untuk mengetahui dampak kebijakan subsidi energi pada energi fosil dan elektrik yang diberikan di Indonesia. Penelitian ini menggunakan pendekatan kuantitatif dan kualitatif (mixed method), dengan teknik analisis regresi melalui Aplikasi STATA 18 dan focus group discussion. Hasil penelitian menunjukkan bahwa masih terdapat beberapa tantangan yang dihadapi pemerintah berkaitan dengan belanja subsidi energi, yaitu terjadinya penyaluran subsidi energi yang tidak tepat sasaran (inclusion error) yang menyebabkan penanggulangan kemiskinan melalui program subsidi energi belum sesuai harapan. Meskipun demikian, terdapat beberapa solusi permasalah dalam upaya meningkatkan kualitas kebijakan dan mulai memikirkan adanya opsi subsidi terhadap kendaraan listrik.
Urgensi Reformasi Hukum Lingkungan Terhadap Perubahan Iklim di Indonesia
Authors: Mahardhika Zerlina Mendy , Hapsari Ivana Mirella , Rajib Rayi Kharisma 
Published: January 2025

Perubahan iklim yang disebabkan oleh aktivitas manusia seperti pembakaran bahan bakar fosil, telah menjadi isu global yang mendesak. Dampaknya mencakup peningkatan suhu global, cuaca ekstrem, dan ancaman terhadap ekosistem. Perubahan iklim di Indonesia sudah terasa, seperti perpanjangan musim hujan dan peningkatan hari-hari kering di beberapa wilayah. Hukum lingkungan memegang peran penting dalam dalam menghadapi kompleksitas perubahan iklim, namun sering dianggap tidak cukup memadai. Oleh karena itu, reformasi hukum lingkungan menjadi penting untuk mengatasi tantangan tersebut. perubahan iklim, serta aspek keadilan dan keberlanjutan bagi semua pihak yang terlibat. Metode penelitian yang digunakan adalah pendekatan yuridis normatif. Tulisan ini bertujuan untuk membahas urgensi reformasi hukum lingkungan terhadap perubahan iklim di Indonesia. Langkah-langkah reformasi yang efektif dan berkelanjutan menjadi kunci dalam menjawab tantangan tersebut, dengan fokus pada perlindungan dan pengelolaan lingkungan hidup. Melalui adanya reformasi legislasi, reformasi pengadilan dan penegak hukum, dan dukungan terhadap upaya inovatif dan pembangunan yang berkelanjutan diharapkan dapat tercipta lingkungan hidup yang lebih berkelanjutan bagi generasi mendatang. Hukum lingkungan penting untuk mitigasi dan adaptasi perubahan iklim, namun sering dianggap tidak memadai apabila penegakan hukum terhadap pelanggaran lingkungan dilakukan secara tidak konsisten dan tidak semestinya. Oleh karena itu, reformasi hukum lingkungan terkait perubahan iklim di Indonesia sangat diperlukan, termasuk pembaruan legislasi, peningkatan kapasitas pengadilan, perlindungan ekosistem, kepatuhan terhadap regulasi, kolaborasi internasional, dukungan inovasi, dan partisipasi masyarakat.
Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue
Authors: Yngve Erik , Ingvast Sofie , Korsgren Olle , Yu Di 
Published: January 2025

Background: Oncolytic viruses are promising tools for immune stimulatory gene therapy of cancer, but their clinical effect on solid tumors have so far been limited. Transduction of the target tumor cells is limited by both extracellular matrix that blocks viral spread within the solid tumor tissue and electrostatic forces that inhibit virus from binding its entry receptor on the cell surface. The enzymes hyaluronidase and collagenase and the polycations diethylaminoethyl (DEAE)-dextran, branched Polyethylenimine (PEI) and protamine sulfate have previously shown potential to improve gene transfer in different forms of viral gene therapy, since they may help the virus to overcome these barriers. In this study, we compared the transduction-enhancing potential of these substances when used as vehicles for adenoviral transduction in solid tumor tissue.
Methods: Subcutaneous tumors of pancreatic ductal adenocarcinoma were established in mice and treated with a mix of adenoviral vector Adf35(GFP-Luc) and either one of the selected vehicles. Transduction efficacy was determined by quantification of the viral transgene expression level using live imaging.
Results: Addition of hyaluronidase tripled the transgene expression of Adf35(GFP-Luc) when compared to virus alone. No such positive effect was seen for the other tested vehicles.
Conclusions: Out of the tested candidates, hyaluronidase showed the best potential to facilitate viral spread in tumor tissue and transduction of tumor cells. Therefore, hyaluronidase may be used as vehicle to improve clinical efficacy of oncolytic virotherapies.
Effect of varying doses of Cisplatin on rat intestinal cell apoptosis
Authors: Kumar P Uday , B Vijayalakshmi , S Kalyanasundaram , M Raghunath , B Sesikeran 
Published: January 2025

The purpose of this study was to (a) determine the dosage of cisplatin required to induce intestinal epithelial cell apoptosis, without causing lethality or necrosis and (b) to assess the biochemical changes in intestinal mucosa with different doses of cisplatin administration. A total of 9 WNIN weanling male rats were divided into three groups (n=3). Groups I and II rats were administered low and high doses of cisplatin intraperitoneally (3 and 12 mg/kg body weight) for three weeks, based on computation from human dose while control rats were administered saline intraperitoneally. Morphometric apoptotic counts increased significantly in both villus and crypt regions of the jejunum in animals of group I but not in animals of group II as compared to control. These changes in apoptotic index correlated with enhanced caspase-3 activity and DNA ladder pattern studies. Increased cell death also resulted in loss of functional integrity of the jejunal mucosa and these events were linked to increased oxidative stress and altered antioxidant enzyme activities. A weekly dose of 3 mg cisplatin/kg body weight appeared to induce intestinal epithelial cell apoptosis in WNIN strain, without causing mortality and could be used as a model for determining the therapeutic and cytoprotective potential of novel test candidates.
Eradication of Pinworms (Syphacia spp.) in a Laboratory Rodent Colony
Authors: Harikrishnan V S , Ranaraj V R , Sreeja K R , Fernandez A C 
Published: January 2025

Laboratory rodent colonies are commonly infested with pinworms namely Syphacia obvelata and Syphacia muris, often results in clinical signs such as diarrhea and rectal prolapse in heavy infestation. The pinworm infestation in rodents affects the experimental observations and hence it is important to eradicate them from the colony. Division of Laboratory Animals at Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) maintains rats and mice colonies. Pinworm ova were determined by perianal impression with cellophane tape testing (CTT) under low power of a compound microscope. The mice and rats were divided into 2 groups with 10 males and 10 females in each group. Group I was treated with piperazine (10.8 mg/ml of drinking water) for a period of 28 days and group II was treated with piperazine (10.8 mg/ml) for a period of 14 days followed by ivermectin (0.01mg/ml) for 14 days. Cages and accessory equipments were disinfected with activated gluteraldehyde, 2.45% w/v. All supplies including bedding and accessories were autoclaved at 121oC temperature, 15 lb pressure for 20 minutes. The present study revealed that the parasites were eradicated from those groups treated with combination drug (piperazine and ivermectin) therapy while the group treated with piperazine alone could not demonstrate a complete eradication. The two drug (piperazine and ivermectin) regime over a 4-week period, associated with appropriate sanitation programme was found to be effective in eradication of pin worms in laboratory rodents.
The AAALAC International Accreditation Program in India
Authors: B Kathryn 
Published: January 2025

Science is a global enterprise, as illustrated by the number and scope of international research collaborations and scientific meetings, as well as the number of journals publishing articles from the international scientific community. As institutions seek to compete on the global market it is critical to ensure an internationally accepted level of animal care and welfare is maintained by institutions using animals for research, testing and education. AAALAC International’s accreditation program utilizes the flexibility of performance standards; is sensitive to differing legal and cultural issues; promotes the “cross fertilization” of information among institutions through the site visit process; highlights best practices; and serves as a benchmark of quality. Through this process, uniform, high standards of animal care and use may be achieved under a broad range of varying national requirements because of the overarching quality assurance derived from AAALAC International’s accreditation program. Accreditation of animal care and use programs in India is a fairly new proposition, but is rapidly gaining attraction. As the biomedical research enterprise in India continues to gain momentum, so too have the merits of an international quality assurance validation system become increasingly recognized. To that end, the AAALAC International accreditation program is herewith described, including observations of findings identified during on-site assessments.