bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidimensional characterization of craniofacial skeletal phenotype of obstructive sleep apnea in adults
Authors: Roh Jae-Yon , Darkhanbayeva Nurdana , Min Hye Kyu , Kim Kyung-A , Kim Su-Jung 
Published: January 2025

Abstract

Objectives
We aimed to characterize a craniofacial skeletal phenotype (CSP) of adult obstructive sleep apnea (OSA) patients from a multidimensional perspective, exploring the impact of transverse skeletal discrepancy (TSD) on multivariable polysomnographic profiles.

Materials and methods
This retrospective, cross-sectional study included 102 adult OSA patients. Sagittal, vertical, and transverse skeletal patterns were categorized on the cone beam computed tomography images. The CSP of OSA patients, characterized by a Class II hyperdivergent pattern, was divided into CSP2D and CSP3D subgroups according to the presence of TSD, and compared with the non-CSP of OSA patients. Both nasal and pharyngeal airway variables were involved for assessment, and 12 polysomnographic variables with a sleepiness symptom variable were used for phenotype-based inter-group comparisons.

Results
The CSP patients revealed greater disease severity than the non-CSP patients (indicated by eight polysomnographic variables), despite being younger (P &lt; .05) and less obese (P &lt; .01). The CSP3D patients with TSD exhibited more severe OSA than the age- and BMI-matched CSP2D patients without TSD, as indicated by nine polysomnographic variables, in relation to smaller nasal airway volume, smaller pharyngeal minimum cross-sectional area, and longer pharyngeal airway length (all P &lt; .05). The probability of multiperspective characteristics among three phenotypes was significantly contrasted in 19 variables.

Conclusions
From a multidimensional perspective, the CSP patients showed greater OSA severity with more vulnerable nasal and pharyngeal airways than non-CSP patients, despite being younger and less obese. Specifically, the CSP3D patients revealed far more severe OSA than the CSP2D patients, indicating the significance of TSD on the polysomnographic profiles.
Effectiveness of a multicentre randomized controlled trial with three different nurse-led intervention management programmes for patients with heart failure: the main results of the MEETinCY study
Authors: Lambrinou Ekaterini , Protopapas Andreas , Paikousis Lefkios , Middleton Nicos , Papathanassoglou Elizabeth D E , Sourtzi Panayota , Kaloyirou Fotini 
Published: January 2025

Abstract

Aims
A single-blinded, multicentred randomized controlled trial (RCT) was employed to examine the effectiveness of a 3-month telephone follow-up, a telephone follow-up with education before discharge, or education only before discharge on the heart failure (HF) knowledge, HF self-care management, and health-related quality of life (HR-QoL) in patients with HF by a nurse specialist.

Methods and results
This is a multicentre RCT with three different intervention groups (IGs) and one control group. Participants in the first IG received education on HF self-management principles before discharge. The second IGs were enrolled to a 3-month telephone follow-up educational programme in addition to the pre-discharge educational session. The third IG received the telephone follow-up intervention only for 3 months. A total of 357 patients with HF were enrolled to the study of whom 262 participants completed the intervention. Outcome measures included HF-related QoL, HF self-care, and HF-related knowledge. Intervention effects were analysed using the Cohen d (rm) coefficient for repeated measurements and ANCOVA. There was a significant improvement in the physical dimension of the HR-QoL (F = 2.7, df = 3, P = 0.046) between the control group and in-person education group. In HF-related self-care, the telephone component alone or in combination with in-person education led to greater improvement than the control group (F = 3, df = 3, P = 0.034). Self-care practices were improved in the education and telephone arms as compared to the control group (P = 0.002).

Conclusion
Education and telephone support on self-care management may improve the physical dimension of HR-QoL.

Registration
ClinicalTrials.gov: NCT01905176
Patients’ views on stroke prevention for atrial fibrillation after an intracerebral haemorrhage: a qualitative study
Authors: Ivany Elena , Lotto Robyn R , Lip Gregory Y H , Lane Deirdre A 
Published: January 2025

Abstract

Aim
(i) To explore the attitudes of patients with atrial fibrillation (AF) towards oral anti-coagulation (OAC) for stroke prevention post-intracerebral haemorrhage (ICH) and (ii) to explore factors that influence patients’ decision-making process for stroke prevention.

Methods and results
Patients with documented diagnosis of AF and history of a non-traumatic ICH, who were eligible for long-term OAC were recruited from eight hospitals in England, using purposive sampling. Data were collected using semi-structured interviews and analysed using Framework analysis. Twelve patients (mean (SD) age 76.2 (6.6) years; 9 men) were recruited. Patients’ main priority was to maintain an acceptable quality of life (QoL), reflected by the main theme ‘Living my life as normal’. When deciding to accept or decline OAC for stroke prevention, patients were influenced by the following: (i) The individual, meaning factors relating to individuals’ personal attitudes towards health and healthcare, (ii) Medical factors, encompassing factors relating to patients’ trust in medical expertise and patients’ information-seeking behaviours, and (iii) Social factors, highlighting the influence of patients’ social support network on patients’ decision-making.

Conclusion
Patients’ decision-making for stroke prevention for AF post-ICH was influenced by individual, medical, and social factors. At the heart of patients’, decision-making were concerns with maintaining an acceptable QoL. The study findings help nurses and other healthcare professionals to better understand what matters to patients who are eligible for stroke prevention for AF post-ICH, thus promoting more effective shared decision making.
Comparing the hermaphroditic mating system of a parasitic flatworm between populations with an ancestral, three-host life cycle and a derived, facultative precocious life cycle
Authors: Hulke Jenna M , Criscione Charles D 
Published: January 2025

Abstract
Evolutionary changes in development and/or host number of parasite life cycles can have subsequent ecological and evolutionary consequences for parasites. One theoretical model based on the mating systems of hermaphroditic parasites assumes a life cycle with fewer hosts will result in more inbreeding, and predicts a truncated life cycle most likely evolves in the absence of inbreeding depression. Many populations of the hermaphroditic trematode Alloglossidium progeneticum maintain an ancestral obligate three-host life cycle where obligate sexual reproduction occurs among adults in catfish third hosts. However, some populations have evolved a facultative precocious life cycle, where sexual development can occur while encysted within crayfish second hosts, likely leading to high inbreeding as individuals are forced to self-mate while encysted. Whether selfing represents a derived state remains untested. We compared selfing rates of 5 precocious populations to that of 4 populations with an ancestral obligate three-host life cycle. We also compared demographic estimates to genetic estimates of selfing to test the prediction of no inbreeding depression in precocious populations. Results showed that while the ancestral obligate three-host life cycle is associated with high outcrossing rates, the facultative precocious populations are highly selfing and show little evidence for inbreeding depression.
Growth inhibition by ppc deletion is rescued by isocitrate dehydrogenase mutations in Escherichia coli
Authors: Toya Yoshihiro , Imada Tatsumi , Ishibashi Mai , Kawamoto Yuichi , Isshiki Kinuka , Shibai Atsushi , Furusawa Chikara , Shimizu Hiroshi 
Published: January 2025

Abstract
Phosphoenolpyruvate carboxylase encoded by ppc catalyzes the anaplerotic reaction of oxaloacetate in the tricarboxylic acid (TCA) cycle in Escherichia coli. Deletion of ppc does not prevent the cells from replenishing oxaloacetate via the glyoxylate shunt, but the ppc-deletion strain almost did not grow on glucose. In the present study, we obtained evolved strains by deleting both ppc and mutS to increase the mutation rate and investigated the mechanisms for improving growth by analyzing the mutated genes. Genome resequencing revealed that the evolved strains have non-synonymous mutations in icd encoding isocitrate dehydrogenase (ICDH). The introduction of icd mutations rescued the growth defects caused by ppc deletion. ICDH activity was strongly reduced by the amino acid substitutions G205D or N232S. The evolved strains appeared to suppress the competitive pathway for increasing the glyoxylate shunt flux. In metabolic engineering, the deletion of iclR, which encodes a repressor of the aceBAK operon, has been used to activate the glyoxylate shunt. The growth rate of the ΔppcΔiclR strain slightly increased, but it was still much lower than that of the Δppc + icdG205D strains. This finding suggests that iclR deletion is not sufficient to enhance glyoxylate shunt flux and that inactivation of the competitive pathway by icd mutations is more effective.
Spiders’ Webs in the Eremenko–Lyubich Class
Authors: Rempe Lasse 
Published: January 2025

Abstract
Consider the entire function $f(z)=\cosh (z)$. We show that the escaping set $I\left(\,f\right)$—that is, the set of points whose orbits tend to infinity under iteration of $f$—has a structure known as a “spider’s web”. This disproves a conjecture of Sixsmith from 2020. In fact, we show that the fast escaping set$A\left(\,f\right)$, consisting of of points whose orbits tend to infinity at an iterated exponential rate, is a spider’s web. This answers a question of Rippon and Stallard from 2012. We also discuss a wider class of functions to which our results apply and state some open questions.
Global Impact of Mass Vaccination Campaigns on Circulating Type 2 Vaccine-Derived Poliovirus Outbreaks: An Interrupted Time-Series Analysis
Authors: Cooper Laura V , Bandyopadhyay Ananda S , Grassly Nicholas C , Gray Elizabeth J , Voorman Arie , Zipursky Simona , Blake Isobel M 
Published: January 2025

Abstract

Background
Between 2016 and 2023, 3248 cases of circulating vaccine-derived type 2 poliomyelitis (cVDPV2) were reported globally and supplementary immunization activities (SIAs) with monovalent type 2 oral poliovirus vaccine (mOPV2) and novel type 2 oral poliovirus vaccine (nOPV2) targeted an estimated 356 and 525 million children, respectively. This analysis estimates the community-level impact of nOPV2 relative to mOPV2 SIAs.

Methods
We fitted interrupted time-series regressions to surveillance data between January 2016 and November 2023 to estimate the impact of nOPV2 and mOPV2 SIAs on cVDPV2 poliomyelitis incidence and prevalence in environmental surveillance across 37 countries, directly comparing the impact of SIAs in 13 countries where both vaccines were used.

Results
We did not find any statistically significant differences between nOPV2 and mOPV2 SIA impact except for in the Democratic Republic of Congo (DRC), where nOPV2 SIAs had lower impact (adjusted relative risk [aRR] for cVDPV2 poliomyelitis incidence per nOPV2 SIA, 0.505; 95% confidence interval [CI], .409–.623) compared to mOPV2 (aRR, 0.193; 95% CI, .137–.272); P value for difference in RRs = 3e-6.

Conclusions
We find variation in OPV2 SIA impacts globally, with greater certainty about Nigeria and DRC, where large outbreaks provided an opportunity to assess impact at scale. In most countries, we find no significant difference between nOPV2 and mOPV2 SIA impact. We are unable to identify the reason for the significant difference in DRC, which could include differential SIA coverage, timing, vaccine effectiveness, or outbreak dynamics.
Estimates of SARS-CoV-2 Infections and Population Immunity After the COVID-19 Pandemic in Austria: Analysis of National Wastewater Data
Authors: Riedmann Uwe , Chalupka Alena , Richter Lukas , Sprenger Martin , Rauch Wolfgang , Schenk Hannes , Krause Robert , Willeit Peter , Oberacher Herbert , Høeg Tracy Beth , Ioannidis John P A , Pilz Stefan 
Published: January 2025

Abstract

Background
Postpandemic surveillance data on coronavirus disease 2019 (COVID-19) infections may help inform future public health policies regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, vaccinations, or other COVID-19 measures. We estimate the total SARS-CoV-2 infections in Austria after the end of the pandemic from wastewater data and utilize these estimates to calculate the average national levels of SARS-CoV-2 infection protection and COVID-19 death protection.

Methods
We estimated the total SARS-CoV-2 infections in Austria after the end of the pandemic (5 May 2023, per World Health Organization) up to May 2024 from wastewater data using a previously published model. These estimates were used in an agent-based model (ABM) to estimate average national levels of SARS-CoV-2 infection protection and COVID-19 death protection, based on waning immunity estimates of infections and vaccination in previous literature.

Results
We estimate approximately 3.2 million infections between 6 May 2023 and 23 May 2024, with a total of 17.8 million infections following 12 May 2020. The ABM estimates that the national average death protection was approximately 82% higher in May 2024 than before the pandemic. This represents a relative decrease of 8% since May 2023. It also shows that 95% of people in Austria were infected with SARS-CoV-2 at least once by May 2024. National infection protection remained relatively low after the onset of Omicron.

Conclusions
These findings should be considered for public health decisions on SARS-CoV-2 testing practices and vaccine booster administrations.
Fluconazole step-down therapy versus echinocandins for the treatment of Candida glabrata invasive candidiasis with candidaemia
Authors: Droney Madeline , Reed Erica , Sarwar Sajed , Coe Kelci , Tran Nikki 
Published: January 2025

Abstract

Objectives
Candida glabrata is the second most common species responsible for invasive candidiasis, including candidaemia. Echinocandins are typically the first-line therapy for C. glabrata candidaemia, with the option to transition to oral fluconazole. Studies are needed to evaluate clinical outcomes in patients initially treated with echinocandins then transitioned to fluconazole.

Methods
This was a retrospective, single-centre cohort study of patients with C. glabrata candidaemia from November 2011 to August 2023. Inpatients aged 18–89 years who received an echinocandin within 24 h of the initial positive blood culture were included. Patients were excluded if they received antifungal treatment less than 48 h, combination therapy, or fluconazole as initial therapy. The primary composite outcome was 30-day clinical failure.

Results
A total of 186 patients were included (n = 153 echinocandin only; n = 33 fluconazole step-down). The most common source of candidaemia was line-associated in both groups with the majority having source control (43% echinocandin versus 58% fluconazole; P = 0.32). Compared to fluconazole, patients in the echinocandin group had a higher rate of concomitant bacteraemia (45% versus 24%; P = 0.03) and endovascular complications (11% versus 0%; P = 0.05). There was no significant difference in treatment duration between echinocandin and fluconazole (16 versus 19 days; P = 0.46), incidence of persistent candidaemia (22% versus 24%; P = 0.7), or 30-day clinical failure (15% versus 9%; P = 0.58).

Conclusions
Fluconazole appears to be a safe and reasonable step-down therapy in the management of C. glabrata candidaemia.
A meta-analysis of gain–loss framing effects in narrative persuasion
Authors: Kim Hye Kyung , Chen Minyi 
Published: January 2025

Abstract
This meta-analytic study synthesizes research on the persuasive impact of gain–loss framing in narrative guided by the social cognitive theory. A combined analysis of 47 experimental studies (N = 16,361) shows an overall persuasive efficacy of gain-framed narratives (vs. loss-framed) at enhancing self-efficacy (d = 0.17, p = .009). The results also indicated that gain-framed narratives produce less counterarguing (d = −0.57, p = .042) and more positive message evaluation (d = 0.25, p = .006) while inducing less transportation (d = −0.07, p = .039) compared to loss-framed narratives. Moderation analyses further revealed loss-framed narratives’ (vs. gain-framed) relative efficacy in improving behavioral intention when the story is written in the third-person perspective or promoting donation behaviors. Study findings illuminate some important boundary conditions and mechanisms of gain–loss framing effects specific to narrative persuasion.
A “rhapsody of the sense of wonder”: G. K. Chesterton’s defense of mysticism in his reading of the Book of Job
Authors: Pratsovyta Nataliya D 
Published: January 2025

ABSTRACT
This article focuses on G. K. Chesterton’s reading of the Book of Job, a text he frequently commented on in his work, to understand the role mysticism plays in Chesterton's interpretation of and response to the question posed by Job about the nature of suffering of the innocent. Approaching Chesterton’s interpretation of this Biblical story through the concept of mysticism allows for an understanding of the meaning and value Chesterton attributed to the phenomenon of mysticism as a lens through which to see the world. Building on Robert Wild’s analysis that sees Chesterton’s reading of the Book of Job as Christ-centric, this article maintains that Chesterton’s analysis of the book is apologetic in nature and offers a defense of mysticism as a part of the Christian approach to life and reality. In Chesterton’s interpretation, God’s monologue in the Book of Job mirrors his own argument about mysticism, pointing to the everyday reality as mystical in nature. The Book of Job does not provide an answer to Job’s question; instead, it calls for a renewed sense of reality and, importantly, points to the connection between the Old and New Testaments, the vision that upholds the tradition of reading of the Book of Job by early medieval Christian thinkers and affirms the Christian apologetic nature of Chesterton’s interpretation of the text.
Vertical kinematics of the young Galactic clusters
Authors: Alfaro Emilio J , Sánchez-Gil M Carmen , Elmegreen Bruce 
Published: January 2025

ABSTRACT
The young disc vertical phase is paramount in our understanding of Galaxy evolution. Analysing the vertical kinematics at different Galactic regions provides important information about the space–time variations of the Galactic potential. The vertical phase snail shell structure identified in Gaia Data Release 2 includes a wide age range. However, the structure of the $V_Z \ \mathrm{ versus} \ Z$ diagram appears linear when the analysis is limited to studying objects younger than 30 Ma. Based on the vertical velocity and height-over-disc maps obtained for a sample of young open clusters, this method also allows the matter density in the solar neighbourhood to be estimated using a completely different approach than previously found in the literature. We use two different catalogues of star clusters to confirm the previous result and study new age ranges. The linear pattern between $V_Z$ and Z shows different slopes, $\partial V_Z/\partial Z$, for various age groups. The results fit a simple model (harmonic oscillator) of in-plane decoupled vertical dynamics up to a certain age limit, corresponding to $\sim$30 Ma. This work also analyses the relationship between the local volumetric density of matter ($\rho _0$) and the disc vertical kinematics for different age ranges, all below 50 Ma. The best estimates of the effective volumetric mass density in the solar neighbourhood, 0.09–0.15 M$_\odot$ pc${}^{-3}$, agree with those given by other authors, assessing the reliability of the proposed dynamical model. These values are a minorant of the actual matter density in the region.
Follow-up on three poorly studied AM CVn stars
Authors: Aungwerojwit Amornrat , Gänsicke Boris T , Breedt E , Arjyotha S , Hermes J J , Hambsch F -J , Kumar A , Ramírez S H , Wilson T G , Dhillon V S , Marsh T R , Poshyachinda S , Scaringi S , Haislip J B , Reichart D E 
Published: January 2025

ABSTRACT
We report follow-up observations of three poorly studied AM CVn-type binaries: CRTS CSS150211 J091017–200813, NSV 1440, and SDSS J183131.63+420220.2. Analysing time-series photometry obtained with a range of ground-based facilities as well as with the Transiting Exoplanet Survey Satellite (TESS), we determine the superhump period of CRTS J0910–2008 as $\rm{P_{sh}}=29.700\pm 0.004$ min and the orbital period of NSV 1440 as $\rm{P_{orb}}=36.56\pm 0.03$ min. We also confirm a photometric period of $P=23.026\pm 0.097$ min in SDSS J1831+4202, which is most likely the superhump period. We also report the first optical spectroscopy of CRTS J0910–2008 and NSV 1440 which unambiguously confirms both as AM CVn systems. We briefly discuss the distribution in the Hertzsprung–Russell diagram of the currently known sample of 63 AM CVn stars with known periods and Gaia data.
Specific modulation of 28S_Um2402 rRNA 2′-O-ribose methylation as a novel epitranscriptomic marker of ZEB1-induced epithelial–mesenchymal transition in different mammary cell contexts
Authors: Morin Chloé , Paraqindes Hermes , Van Long Flora Nguyen , Isaac Caroline , Thomas Emilie , Pedri Dennis , Pulido-Vicuna Carlos Ariel , Morel Anne-Pierre , Marchand Virginie , Motorin Yuri , Carrere Marjorie , Auclair Jessie , Attignon Valéry , Pommier Roxane M , Ruiz Emmanuelle , Bourdelais Fleur , Catez Frédéric , Durand Sébastien , Ferrari Anthony , Viari Alain , Marine Jean-Christophe , Puisieux Alain , Diaz Jean-Jacques , Moyret-Lalle Caroline , Marcel Virginie 
Published: January 2025

Abstract
The epithelial–mesenchymal transition (EMT) is a dynamic transdifferentiation of epithelial cells into mesenchymal cells. EMT programs exhibit great diversity, based primarily on the distinct impact of molecular activities of the EMT transcription factors. Using a panel of cancer cell lines and a series of 71 triple-negative primary breast tumors, we report that the EMT transcription factor ZEB1 modulates site-specific chemical modifications of ribosomal RNA (rRNA). Overexpression of ZEB1 and ZEB2, but not TWIST1, decreased the level of 2′-O-ribose methylation (2′Ome) of 28S rRNA at position Um2402. ZEB1 overexpression specifically reduced the expression of the corresponding C/D box small nucleolar RNAs (snoRNAs) SNORD143/144, which guide the rRNA 2′Ome complex at the 28S_Um2402 site. During ZEB1-induced EMT induction/reversion, the levels of both 2′Ome at 28S_Um2402 and SNORD143/144 were dynamically comodulated. Taken together, these data demonstrate that 2′Ome rRNA epitranscriptomics is a novel marker of ZEB1-induced EMT.