bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Improvement in Patient-Reported Knee Function After Revision and Multiple-Revision ACL Reconstruction Compared With Primary ACL Reconstruction
Authors: Kaarre Janina , Herman Zachary J. , Grassi Alberto , Hamrin Senorski Eric , Musahl Volker , Samuelsson Kristian 
Published: December 2023

Background: Graft failure after anterior cruciate ligament reconstruction (ACLR) is a debilitating complication often requiring revision surgery. It is widely agreed upon that functional knee outcomes after revision ACLR (r-ACLR) are inferior compared with those after primary reconstruction. However, data are scarce on outcomes after multiple-revision ACLR (mr-ACLR). Purpose: To compare patient-reported knee function in terms of Knee injury and Osteoarthritis Outcome Score (KOOS) preoperatively and 1-year postoperatively after primary ACLR, r-ACLR, and mr-ACLR and evaluate the pre- to postoperative improvement in KOOS scores for each procedure. Study Design: Cohort study; Level of evidence, 3. Methods: Patients from the Swedish National Knee Ligament Registry who underwent their index ACLR between 2005 and 2020 with a minimum age of 15 years at the time of surgery were included in this study. All patients had pre- and postoperative KOOS data. The 1-year postoperative KOOS and the pre- to postoperative changes in KOOS were assessed between patients who underwent primary ACLR and those who underwent subsequent r-ACLR and mr-ACLR. Results: Of 20,542 included patients, 19,769 (96.2%) underwent primary ACLR, 760 (3.7%) underwent r-ACLR, and 13 (0.06%) underwent mr-ACLR. Patients who underwent r-ACLR had significantly smaller pre- to postoperative changes on all KOOS subscales compared with patients undergoing primary ACLR ( P < .0001 for all). Furthermore, patients in the mr-ACLR group had significantly smaller changes in the KOOS-Pain subscale compared with patients in the r-ACLR group (–9 ± 23.3 vs 2.5 ± 18; P = .024). Conclusion: The study results indicated that while improvement is seen after primary ACLR, r-ACLR, and mr-ACLR, the greatest improvement in functional outcomes is observed after primary ACLR. Patients who underwent at least 1 r-ACLR, specifically mr-ACLR, had lower postoperative outcome scores, indicating that primary ACLR may provide the best chance for recovery after ACL injury.
The role of the diaphragm in prediction of respiratory function in the immediate postoperative period in lung cancer patients using a machine learning model
Authors: Vesovic Radomir , Milosavljevic Milan , Punt Marija , Radomirovic Jelica , Bascarevic Slavisa , Savic Milan , Milenkovic Vladimir , Popovic Marko , Ercegovac Maja 
Published: December 2023

Abstract
Background
The prediction of postoperative respiratory function is necessary in identifying patients that are at greater risk of complications. There are not enough studies on the effect of the diaphragm on postoperative respiratory function prediction in lung cancer surgical patients. The objective of this study is to estimate the precision of machine learning methods in the prediction of respiratory function in the immediate postoperative period and how diaphragm function contributes to that prediction.

Materials and methods
Our prospective study included 79 patients who underwent lung cancer surgery. Diaphragm function was estimated by its mobility measured both ultrasonographically and radiographically and by noninvasive muscle strength tests. We present a new machine learning multilayer regression metamodel, which predicts FEV1 for each patient based on preoperative measurements.

Results
The proposed regression models are specifically trained to predict FEV1 in the immediate postoperative period and were proved to be highly accurate (mean absolute error in the range from 8 to 11%). Predictive models based on resected segments give two to three times less precise results. Measured FEV1 was 44.68% ± 14.07%, 50.95% ± 15.80%, and 58.0%1 ± 14.78%, and predicted postoperative (ppo) FEV1 was 43.85% ± 8.80%, 50.62% ± 9.28%, and 57.85% ± 10.58% on the first, fourth, and seventh day, respectively. By interpreting the obtained model, the diaphragm contributes to ppoFEV1 13.62% on the first day, 10.52% on the fourth, and 9.06% on the seventh day.

Conclusion
The machine learning metamodel gives more accurate predictions of postoperative lung function than traditional calculations. The diaphragm plays a notable role in the postoperative FEV1 prediction.
Evaluation of the Effectiveness of Superficial Parotidectomy and Partial Superficial Parotidectomy for Benign Parotid Tumours: A Meta-Analysis
Authors: Liu Hai-Tao , Jiang Wei-Peng , Xia Gang , Liao Jia-Min 
Published: December 2023

Objective To quantify the results of superficial parotidectomy (SP) and partial SP (PSP) for benign parotid tumours using a systematic evaluation method. Methods A systematic search of English and Chinese databases (PubMed, Web of Science, Cochrane Library, China Knowledge Network, Wanfang and Vipshop) was conducted to include studies comparing the treatment outcomes of SP with PSP. Results Twenty-three qualified, high-quality studies involving 2844 patients were included in this study. The results of this study showed that compared to the SP surgical approach, the PSP surgical approach reduced the occurrence of temporary facial palsy (OR = 0.33; 95% confidence interval [CI] 0.26–0.41), permanent facial palsy (OR = 0.28; 95% CI 0.16–0.52) and Frey syndrome (OR = 0.36; 95% CI 0.23–0.56) in patients after surgery, and the surgery operative time was reduced by approximately 27.35 min (95% CI − 39.66, − 15.04). However, the effects of PSP versus SP on salivary fistula (OR = 0.70; 95% CI 0.40–1.24), sialocele (OR = 1.48; 95% CI 0.78–2.83), haematoma (OR = 0.34; 95% CI 0.11–1.01) and tumour recurrence rate (OR = 1.41; 95% CI 0.48–4.20) were not statistically significant. Conclusion Compared with SP, PSP has a lower postoperative complication rate and significantly shorter operative time, suggesting that it could be used as an alternative to SP in the treatment of benign parotid tumours with the right indications. Graphical abstract
Students’ perceptions of using ChatGPT in a physics class as a virtual tutor
Authors: Ding Lu , Li Tong , Jiang Shiyan , Gapud Albert 
Published: December 2023

AbstractThe latest development of Generative Artificial Intelligence (GenAI), particularly ChatGPT, has drawn the attention of educational researchers and practitioners. We have witnessed many innovative uses of ChatGPT in STEM classrooms. However, studies regarding students’ perceptions of ChatGPT as a virtual tutoring tool in STEM education are rare. The current study investigated undergraduate students’ perceptions of using ChatGPT in a physics class as an assistant tool for addressing physics questions. Specifically, the study examined the accuracy of ChatGPT in answering physics questions, the relationship between students’ ChatGPT trust levels and answer accuracy, and the influence of trust on students’ perceptions of ChatGPT. Our finding indicates that despite the inaccuracy of GenAI in question answering, most students trust its ability to provide correct answers. Trust in GenAI is also associated with students’ perceptions of GenAI. In addition, this study sheds light on students’ misconceptions toward GenAI and provides suggestions for future considerations in AI literacy teaching and research.
Social support in low-income women with Fibromyalgia Syndrome from a sub-urban and peri-urban areas of Tenerife (Canary Islands, Spain): a mixed method study
Authors: Martín Pérez Sebastian Eustaquio , Martín Pérez Isidro Miguel , Álvarez Sánchez Ania , Acosta Pérez Paula , Rodríguez Alayón Eliana 
Published: December 2023

Abstract
Background
Women with Fibromyalgia Syndrome (FMS) can benefit form adequate social support to fight the consequences of their illness, but the extent to which this is available to those with low incomes who live in depressed areas of Tenerife (Canary Islands, Spain) is currently unknown. The purpose of this study was to explore social support in low-incomes women with FMS in sub-urban and peri-urban areas of Tenerife.

Methodology
A sequential exploratory mixed method study was carried out from January 20, 2023, to June 10, 2023, at the Fibromyalgia and Chronic Fatigue Association of Tenerife (AFITEN) using non-probability convenience sampling. Social support was analyzed quantitatively through MOS-SSS survey and Duke-UNC-11 questionnaire, while qualitative data were obtained through semi-structured interviews to identify social support providers and analyze their satisfactions levels.

Results
A total of 49 women, with a mean age of 57.80 years-old (SD = 13.25) were finally included in this study. MOSS-SSS and Duke-UNC-11 both indicated lower social support levels at 68.6 (SD =16.3) and 38.0 (SD = 9.74), respectively. The qualitative analysis revealed that partners and friends provided the most significant support with the highest satisfaction scores.

Conclusions
The socioeconomic status of low-income women with FMS living in sub-urban and peri-urban areas of Tenerife (Canary Islands, Spain) influences on their social support, with the affective support and confidentiality being the most affected dimensions.
Assessing the influence of personality and health beliefs on variability of COVID-19 fear among Egyptians: a cross-sectional study
Authors: Atwa Samar , Bassiony Medhat M. , Said Mervat , Fouad Eman 
Published: December 2023

Abstract
Background
Patients and their families get stigmatized and socially excluded due to their fear of COVID-19, which exposes them to psychological discomfort, rage, depression, and anxiety. The purpose of this study was to assess the fear the Egyptian population had of COVID-19 and its risk factors during the pandemic.

Methods
In this study, 1002 Egyptian adults joined part via a cross-sectional online survey.
The survey included questions related to sociodemographic and clinical data, the Health Belief Model (HBM), The Arabic Big Five Personality Inventory (ABFPI), and the Fear of COVID-19 Scale (FCV-19S).

Results
Marriage status, rural residence, non-medical work, lack of satisfaction with personal information about COVID-19, high perceived severity, perceived benefits of social distance, and high scores of neuroticism significantly increased the risk of fear from COVID-19, while low perceived susceptibility and high conscientiousness were protective factors against the fear of covid-19.

Conclusions
Personality traits and health beliefs play an important role in COVID-19-related fear during the pandemic. These findings might help in the planning of prevention programs in the future.
Mutation of p53 increases the competitive ability of pluripotent stem cells
Authors: Perez Montero Salvador , Paul Pranab K. , di Gregorio Aida , Bowling Sarah , Shepherd Solomon , Fernandes Nadia J. , Lima Ana , Pérez-Carrasco Rubén , Rodriguez Tristan A. 
Published: December 2023

ABSTRACT
During development, the rate of tissue growth is determined by the relative balance of cell division and cell death. Cell competition is a fitness quality-control mechanism that contributes to this balance by eliminating viable cells that are less fit than their neighbours. The mutations that confer cells with a competitive advantage and the dynamics of the interactions between winner and loser cells are not well understood. Here, we show that embryonic cells lacking the tumour suppressor p53 are ‘super-competitors’ that eliminate their wild-type neighbours through the direct induction of apoptosis. This elimination is context dependent, as it does not occur when cells are pluripotent and it is triggered by the onset of differentiation. Furthermore, by combining mathematical modelling and cell-based assays we show that the elimination of wild-type cells is not through competition for space or nutrients, but instead is mediated by short-range interactions that are dependent on the local cell neighbourhood. This highlights the importance of the local cell neighbourhood and the competitive interactions within this neighbourhood for the regulation of proliferation during early embryonic development.
When Nash Meets Stackelberg
Authors: Carvalho Margarida , Dragotto Gabriele , Feijoo Felipe , Lodi Andrea , Sankaranarayanan Sriram 
Published: December 2023

This article introduces a class of Nash games among Stackelberg players (NASPs), namely, a class of simultaneous noncooperative games where the players solve sequential Stackelberg games. Specifically, each player solves a Stackelberg game where a leader optimizes a (parametrized) linear objective function subject to linear constraints, whereas its followers solve convex quadratic problems subject to the standard optimistic assumption. Although we prove that deciding if a NASP instance admits a Nash equilibrium is generally a [Formula: see text]-hard decision problem, we devise two exact and computationally efficient algorithms to compute and select Nash equilibria or certify that no equilibrium exists. We use NASPs to model the hierarchical interactions of international energy markets where climate change aware regulators oversee the operations of profit-driven energy producers. By combining real-world data with our models, we find that Nash equilibria provide informative, and often counterintuitive, managerial insights for market regulators. This paper was accepted by Chung Piaw Teo, optimization. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03418 .
Zero-One Composite Optimization: Lyapunov Exact Penalty and a Globally Convergent Inexact Augmented Lagrangian Method
Authors: Zhang Penghe , Xiu Naihua , Luo Ziyan 
Published: December 2023

We consider the problem of minimizing the sum of a smooth function and a composition of a zero-one loss function with a linear operator, namely the zero-one composite optimization problem (0/1-COP). It has a vast body of applications, including the support vector machine (SVM), calcium dynamics fitting (CDF), one-bit compressive sensing (1-bCS), and so on. However, it remains challenging to design a globally convergent algorithm for the original model of 0/1-COP because of the nonconvex and discontinuous zero-one loss function. This paper aims to develop an inexact augmented Lagrangian method (IALM), in which the generated whole sequence converges to a local minimizer of 0/1-COP under reasonable assumptions. In the iteration process, IALM performs minimization on a Lyapunov function with an adaptively adjusted multiplier. The involved Lyapunov penalty subproblem is shown to admit the exact penalty theorem for 0/1-COP, provided that the multiplier is optimal in the sense of the proximal-type stationarity. An efficient zero-one Bregman alternating linearized minimization algorithm is also designed to achieve an approximate solution of the underlying subproblem in finite steps. Numerical experiments for handling SVM, CDF, and 1-bCS demonstrate the satisfactory performance of the proposed method in terms of solution accuracy and time efficiency. Funding: This work was supported by the Fundamental Research Funds for the Central Universities [Grant 2022YJS099] and the National Natural Science Foundation of China [Grants 12131004 and 12271022].
Mendelian randomization provides evidence for a causal effect of serum insulin-like growth factor family concentration on risk of atrial fibrillation
Authors: Lin Sha , Tang Jie , Li Xing , Wu Gang , Lin Yi-Fei , Li Yi-Fei 
Published: December 2023

BACKGROUND
Atrial fibrillation (AF) is one of the most common persistent arrhythmias among adult cardiovascular diseases. It is important to identify potential risk factors for AF. Members of the insulin-like growth factor (IGF) family exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases, and previous population-based studies indicate associations between IGF family members and AF. However, the causal effects of IGF family members in AF have not been evaluated.
AIM
In the current study two-sample Mendelian Randomization (MR) was used to assess genetic relationships between IGF family members and AF.
METHODS
MR was performed based on genome-wide association study (GWAS) datasets, and concentration levels of 14 IGF family members were retrieved. An initial MR analysis was conducted to identify single nucleotide polymorphisms potentially associated with IGF serum concentrations. A GWAS meta-analysis including 60620 AF cases and 970216 control participants of European ancestry was then conducted to identify AF causal effects. Two-sample MR packages were used to perform MR analysis in R. MR-Egger, weighted median (WM), and inverse variance weighted (IVW) methods were used.
RESULTS
In two-sample MR assessments there were lower levels of circulating IGF binding protein 3 in both WM [odds ratio (OR) 0.964, 95% confidence interval (CI) 0.940–0.960, P = 0.006] and IVW (OR 0.968, 95%CI: 0.947–0.987, P = 0.001) analyses. Higher serum levels of IGF2 receptor were associated with AF (OR 1.045, 95%CI: 1.016–1.076, P = 0.039). In reverse MR analysis conducted to investigate casual effects, elevated levels of circulating CYR61 were associated with AF (OR 1.060, 95%CI: 1.005–1.119, P = 0.031).
CONCLUSION
The results of the present study provide novel insights into the pathogenesis of AF, and the implications of serum IGF family member concentrations when assessing the risk of AF. The study generated evidence on the potential roles of developmental pathological effects in the pathogenesis of AF. Further observational and experimental studies are critically needed.
Iris metastasis from clear cell renal cell carcinoma: A case report
Authors: Wang Tong-Tong , Chen Xiao-Yue , Min Qiao-Yun , Han Yi-Ze , Zhao Huan-Fen 
Published: December 2023

BACKGROUND
Clear cell renal cell carcinoma (ccRCC) is a common type of tumor that can metastasize to any organs and sites. However, it is extremely rare for ccRCC to metastasize to the iris. Here, we describe a rare case of iris metastasis from ccRCC with a history of left nephrectomy in 2010.
CASE SUMMARY
A 62-year-old male was admitted to the hospital due to blurred vision and red eyes, and a mass was found on the iris in the right eye. B-scan ultrasonography revealed a well-bounded high-density lesion at the corner of the anterior chamber at the 3-4 o’clock position. Phacoemulsification with simultaneous intraocular lens implantation and iridocyclectomy was performed in the right eye. The lesion was confirmed to be metastatic ccRCC by histological and immunohistochemical analyses. The patient was still alive at 9 mo after surgical treatment. Ocular metastasis can be an initial sign with a poor prognosis. Timely detection and treatment may improve survival. Clinicians should pay attention to similar metastatic diseases to prevent misdiagnosis leading to missed treatment opportunities.
CONCLUSION
This report of the characteristics and successful management of a rare case of iris metastasis from ccRCC highlights the importance of a comprehensive medical history, histopathology, immunohistochemistry, and clinical manifestation for successful disease diagnosis.
Spinal cord infarction attributed to SARS-CoV-2, with post-acute sequelae of COVID-19: A case report
Authors: Oleson Christina V , Olsen Andrew C , Shermon Suzanna 
Published: December 2023

BACKGROUND
While stroke and lower extremity venous thromboemboli have been commonly reported following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spinal cord infarction or ischemia has been extremely rare. Findings of long coronavirus disease (COVID) in this select population have not been studied.
CASE SUMMARY
We present the case of a 70-year-old female with sudden onset of trunk and lower extremity sensorimotor loss due to spinal cord infarction, attributed to acute infection with SARS-CoV-2. Diagnostic work up confirmed a T3 complete (ASIA impairment Scale A) paraplegia resulting from a thrombotic infarct. Her reported myalgias, neuropathic pain, spasticity, bladder spasms, and urinary tract infections exceeded the frequency and severity of many spinal cord injury (SCI) individuals of similar age and degree of neurologic impairment. In her first year after contracting COVID-19, she underwent 2 separate inpatient rehabilitation courses, but also required acute hospitalization 6 additional times for subsequent infections or uncontrolled pain. Yet other complications of complete non-traumatic SCI (NTSCI), including neurogenic bowel and temperature hypersensitivity, were mild, and pressure injuries were absent. She has now transitioned from the acute to chronic phase of spinal cord injury care, with subsequent development of post-acute sequelae of SARS-CoV-2 infection (PASC).
CONCLUSION
This individual experienced significant challenges with the combined effects of acute T3 NTSCI and acute COVID-19, with subsequent progression to PASC.
Intraoperative cardiogenic shock induced by refractory coronary artery spasm in a patient with myasthenia gravis: A case report
Authors: Hsu Cheng-Wei , Chang Chuen-Chau , Lin Chao-Shun 
Published: December 2023

BACKGROUND
Coronary artery spasm (CAS) is a rare but critical condition during surgery. Clinical manifestations can vary from only subtle electrocardiography change to sudden death. In this case report, we present the case of a patient with myasthenia gravis (MG) who developed refractory CAS-related cardiogenic shock during thymoma surgery.
CASE SUMMARY
A 61-year-old man had a history of cigarette smoking and coronary artery disease with a bare metal stent placed. Three months ago, he suffered from coronary spasms, with three vessels involved, after surgery for cervical spine injury. He started having progressive dysphagia 4 wk prior and was diagnosed with MG via serologic tests, and computed tomography declared a thymoma in the anterior mediastinum. After the symptoms of MG subsided, he was referred for thymectomy. The operation was uneventful until the closing of the sternal wound. Electrocardiography showed sudden onset ST elevation, followed by ventricular tachycardia and severe hypotension. Cardiopulmonary cerebral resuscitation was initiated immediately with electrical defibrillation, extracorporeal membrane oxygenation was performed due to refractory cardiogenic shock, and the patient was transferred to an angiography room. Angiography showed diffuse CAS with three vessels involved. Intracoronary isosorbide dinitrate and adenosine were administered, and then the patient was transferred to the intensive care unit.
CONCLUSION
Our case highlights the importance of being prepared for clinical situations such as the one described here and suggests the necessity of developing an appropriate anesthesia plan that includes proactive analgesia and preemptive coronary vasodilators.
Rotational position error correction in ptychography
Authors: Lin Angyi , Sheng Pengju , Ning Shoucong , Zhang Fucai 
Published: December 2023

Accurate determination of scan positions is essential for achieving high-quality reconstructions in ptychographic imaging. This study presents and demonstrates a method for determining the rotation angle of the scan pattern relative to the detector pixel array using diffraction data. The method is based on the Fourier–Mellin transform and cross-correlation calculation. It can correct rotation errors up to 60 deg. High-quality reconstructions were obtained for visible light and electron microscopy datasets, and intricate structures of samples can be revealed. We believe that this refinement method for rotary position errors can be valuable for improving the performance of ptychographic four-dimensional scanning transmission electron microscopy.