bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negotiating access to community-based participatory research
Authors: Ehsan Annahita 
Published: November 2023

Abstract
Purpose
Community-based participatory research (CBPR) that improves social capital can be a powerful tool for promoting mental health and well-being. This work explores what gaining, maintaining, and losing access to this type of CBPR looks like from a reflexive research perspective.

Method
I describe and reflect on my experiences conducting a mixed-methods study of an existing CBPR to increase social capital in Switzerland. I draw on ethnographic observations, field notes, and reflexive memos collected during fieldwork between 2016 and 2020.

Results
I negotiated access to the CBPR across three levels: (1) formal organizational with intervention leaders, (2) implementational with facilitators, and (3) the community/group level with participants. Intervention leaders let me conduct research if they benefitted from my work in a timely and reinforcing way, facilitators granted access if I made myself helpful and supported their work, and community members accepted me if I participated in their community meaningfully. I lost access when my findings posed a potential risk to the intervention funding.

Conclusion
I highlight how access is a fluid and complex process that can change throughout CBPR. I show the importance of reflexive analysis to understand how access is negotiated in diverse settings, what sources of social capital are needed to engage in these negotiations, and how positionality and power play a role in this process.
Selbst beigebrachte Schädeltrepanationen
Authors: Babian C. , Mueller W. C. , Dreßler J. 
Published: November 2023

ZusammenfassungEin 78 Jahre alt gewordener Mann hatte sich 8 Bohrlochverletzungen am Hirnschädel bei später diagnostiziertem Aneurysma cerebri beigebracht. Als wahrscheinlichstes Motiv für die außergewöhnliche Tat ist ein Vernichtungskopfschmerz anzunehmen. Nach 5‑tägiger Überlebenszeit trat der Tod im Multiorganversagen mit akutem Myokardinfarkt unter Therapiebegrenzung ein. Eine Fremdeinwirkung konnte ausgeschlossen werden.
A US real-world study of treatment patterns and outcomes in localized or locally advanced prostate cancer patients
Authors: Freedland Stephen J. , Nair Sandhya , Lin Xiwu , Karsh Lawrence , Pieczonka Christopher , Potluri Ravi , Brookman-May Sabine D. , Mundle Suneel D. , Fleming Sarah , Agarwal Neeraj 
Published: November 2023

Abstract
Purpose
Men with localized or locally advanced prostate cancer (LPC/LAPC) are at risk of progression after radiotherapy (RT) or radical prostatectomy (RP). Using real-world data, we evaluated patient characteristics, treatment patterns, and outcomes in LPC/LAPC.

Methods
Optum claims and electronic health records (EHR) data from January 2010 to December 2021 were queried for men with LPC/LAPC who received primary RT, RP, or androgen deprivation therapy alone within 180 days after diagnosis. Survival outcomes were analyzed using descriptive statistics and Kaplan–Meier curves. Real-world overall survival (rwOS) was compared in patients with and without evidence of disease (i.e., disease recurrence, metastasis, diagnosis of castration-resistant PC) at defined time points.

Results
61,772 and 62,361 men in claims and EHR cohorts met the inclusion criteria. Median follow-up was 719 and 901 days, respectively. Most men received primary RT (51.0% claims, 35.0% EHR) or RP (39.4% claims, 53.8% EHR). Survival was greatest among men treated with RP, followed by RT. Adjusted for age and comorbidity, rwOS was shorter among men with evidence of disease within 1, 3, 4, and 5 years after primary treatment than those without at the same time points.

Conclusion
Real-world claims and EHR data show that survival among men with LPC/LAPC differs by primary treatment and time point of disease recurrence thereafter. Poor outcomes in men with LPC/LAPC who progress early indicate an unmet medical need for more effective primary treatment. If validated for surrogacy, no evidence of disease at specific time points could represent an intermediate efficacy endpoint in future trials.
Depot medroxyprogesterone acetate and breast cancer: a systematic review
Authors: Zürcher Aline , Knabben Laura , von Gernler Marc , Stute Petra 
Published: November 2023

Abstract
Purpose
Short-acting progestin-only injectables containing depot medroxyprogesterone acetate (DMPA) are a safe method of contraception. Although DMPA has been available for several decades, there is little data on its influence on the risk of breast cancer. Hence, the aim of this paper was to provide an overview of the existing studies and create clarity regarding a possible association with breast cancer.

Methods
Literature searches were executed in MEDLINE, Embase, the Cochrane Library, ClinicalTrials.gov and ICTRP. Search terms were related to DMPA and breast cancer. After elimination of duplicates, 3′850 studies were identified and assessed according to inclusion and exclusion criteria. Finally, ten studies were selected and included in this review.

Results
All the selected papers were case–control-studies, except for one pooled analysis and one study comparing observed and expected number of cancer cases.
Most of the included studies found no overall elevated breast cancer incidence in DMPA users, only one study found a slightly increased risk and two studies concluded with a significant increase for the overall breast cancer risk.

Conclusion
There is little evidence that DMPA may increase the overall risk for breast cancer. However, the incidence of breast cancer is possibly increased in current and more recent users, especially in women younger than 35 years. Long-term use did not result in any risk increase. Nevertheless, further studies will be necessary to confirm these findings and weigh up the individual risks and benefits of this contraceptive method.
CRP as an early indicator for anastomotic leakage after esophagectomy for cancer: a single tertiary gastro-esophageal center study
Authors: Ri Motonari , Tzortzakakis Antonios , Sotirova Ira , Tsekrekos Andrianos , Klevebro Fredrik , Lindblad Mats , Nilsson Magnus , Rouvelas Ioannis 
Published: November 2023

Abstract
Purpose
To determine the relationship between postoperative C-reactive protein (CRP) as an early indicator of anastomotic leakage (AL) after esophagectomy for esophageal cancer.

Methods
We reviewed patients diagnosed with esophageal or esophagogastric junctional cancer who underwent esophagectomy between 2006 and 2022 at the Karolinska University Hospital, Stockholm, Sweden. Multivariable logistic regression models estimated relative risk for AL by calculating the odds ratio (OR) with a 95% confidence interval (CI). The cut-off values for CRP were based on the maximum Youden’s index using receiver operating characteristic curve analysis.

Results
In total, 612 patients were included, with 464 (75.8%) in the non-AL (N-AL) group and 148 (24.2%) in the AL group. Preoperative body mass index and the proportion of patients with the American Society of Anesthesiologists physical status classification 3 were significantly higher in the AL group than in the N-AL group. The median day of AL occurrence was the postoperative day (POD) 8. Trends in CRP levels from POD 2 to 3 and POD 3 to 4 were significantly higher in the AL than in the N-AL group. An increase in CRP of ≥ 4.65% on POD 2 to 3 was an independent risk factor for AL with the highest OR of 3.67 (95% CI 1.66–8.38, p = 0.001) in patients with CRP levels on POD 2 above 211 mg/L.

Conclusion
Early changes in postoperative CRP levels may help to detect AL early following esophageal cancer surgery.
Kinematic analysis of chewing and swallowing function after cervical spine surgery
Authors: Aritaki Kota , Nakagawa Kazuharu , Yoshimi Kanako , Yoshizawa Akira , Hasegawa Shohei , Yanagida Ryosuke , Hashimoto Motonori , Hirai Takashi , Yamaguchi Kohei , Nakane Ayako , Yoshii Toshitaka , Okawa Atsushi , Tohara Haruka 
Published: November 2023

Abstract
Purpose
Although movement of the hyoid bone is different for masticatory swallowing and liquid swallowing in normal subjects, it has not been studied after cervical spine surgery. Therefore, we analyzed the swallowing dynamics of masticatory swallowing in anterior cervical spine disease surgery using foods that require chewing close to actual meals.

Methods
A day before and one week after the surgery, a videofluoroscopic swallow study (VFSS) was performed, and the distance of hyoid bone movement in the anterior and superior directions, amount of opening of the upper esophageal sphincter (UES), time of passage through the pharynx, number of swallows, and amount of pharyngeal residual were measured on the VFSS images during a masticatory swallow of corn flakes. The swallowing function was evaluated by DSS (dysphagia severity scale) and FOIS (functional oral intake scale). Imaging software was used for the measurements.

Results
Postoperative hyoid movement during masticatory swallowing was not significantly different for anterior movement but significantly limited in upward movement (p = 0.002); UES opening volume was significantly decreased (p < 0.001), and bolus residue was significantly worse (p < 0.001), compared to preoperative. The pharyngeal transit time was not significantly different; the number of swallows increased (p < 0.001), along with DSS (p < 0.001) and FOIS (p < 0.001), with significant differences before and after surgery, indicating worsened swallowing function.

Conclusions
Swallowing function worsened in masticatory swallowing after surgery for cervical spine disease, mainly due to the restriction of upward movement of the hyoid bone and the resulting increase in pharyngeal residuals after swallowing.
A novel antibacterial approach of Cecropin-B peptide loaded on chitosan nanoparticles against MDR Klebsiella pneumoniae isolates
Authors: Okasha Hend , Dahroug Heba , Gouda Abdullah E. , Shemis Mohamed Abbas 
Published: November 2023

AbstractEgypt has witnessed the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae, which has posed a serious healthcare challenge. The proper treatment choice for MDR-KP infections is not well determined which renders the problem more complicated, thus making the control of such infections a serious challenge for healthcare professionals. This study aims to encapsulate the cationic antimicrobial peptide; Cecropin-B (Cec-B), to increase its lifetime, drug targeting, and efficacy and study the antimicrobial effect of free and encapsulated recombinant rCec-B peptide on multidrug-resistant K. pneumoniae (MDR-KP) isolates. Fifty isolates were collected from different clinical departments at Theodore Bilharz Research Institute. Minimal inhibitory concentrations (MICs) of rCec-B against MDR-KP isolates were determined by the broth microdilution test. In addition, encapsulation of rCec-B peptide into chitosan nanoparticles and studying its bactericidal effect against MDR-KP isolates were also performed. The relative expression of efflux pump and porin coding genes (ArcrB, TolC, mtdK, and Ompk35) was detected by quantitative PCR in treated MDR-KP bacterial isolates compared to untreated isolates. Out of 60 clinical MDR isolates, 50 were MDR-KP. 60% of the isolates were XDR while 40% were MDR. rCec-B were bactericidal on 21 isolates, then these isolates were subjected to treatment using free nanocapsule in addition to the encapsulated peptide. Free capsules showed a mild cytotoxic effect on MDR-KP at the highest concentration. MIC of encapsulated rCec-B was higher than the free peptide. The expression level of genes encoding efflux and porin (ArcrB, TolC, mtdK, and Ompk35) was downregulated after treatment with encapsulated rCec-B. These findings indicate that encapsulated rCec-B is a promising candidate with potent antibacterial activities against drug-resistant K. pneumoniae.
When time worsens framing: a longitudinal analysis of the psychological effects of the COVID-19 pandemic in women with an eating disorder and their healthy sisters
Authors: Meneguzzo Paolo , Ceccato Enrico , Sala Alessandra , Santonastaso Paolo 
Published: November 2023

AbstractThe COVID-19 pandemic has profoundly affected individuals with eating disorders (ED), leading to an exacerbation of symptoms worldwide in 2020. However, there is a lack of longitudinal analyses of the psychological burdens experienced by this population. This study aims to longitudinally assess the psychological effects of the COVID-19 pandemic in people with ED and their healthy sisters (HS) 1 and 2 years after the onset of the crisis. A sample of 148 individuals, consisting of 73 with ED and 45 HS, was evaluated in spring 2021 and spring 2022 regarding their current psychological and behavioral states. Participants were also asked to reflect on their feelings and behaviors during the 2020 lockdown. General psychopathology, eating disorders, and trauma-related symptoms were evaluated using validated questionnaires. Both groups showed an overall improvement in psychopathological symptoms with time. Individuals with ED exhibited greater improvement compared to their HS, which may be attributed to their initially higher burden. Individuals with ED reported a negative reframe, characterized by internalizing negative emotions and behaviors related to the 2020 lockdown. This longitudinal evaluation revealed two distinct and contrasting effects. Both ED patients and their HS demonstrated psychological improvement over time. However, people with ED experienced a negative reframe that affected their memory of specific life events, subsequently affecting their psychological well-being. These findings shed light on the clinical severity observed in people with ED during these pandemic years.
How have public healthcare providers in Sweden conformed to the European Union’s Web Accessibility Directive regarding accessibility statements on their websites?
Authors: Jonsson Marika , Gustavsson Catharina , Gulliksen Jan , Johansson Stefan 
Published: November 2023

AbstractThe Web Accessibility Directive (WAD) is part of the European Union’s work for digital inclusion. The WAD obligates that public sector bodies’ websites meet accessibility standards and provide an accessibility statement on the website informing about inaccessible content, and a feedback mechanism for reporting accessibility issues or requesting inaccessible content in an accessible format. The objective of this study was to evaluate how healthcare providers in Sweden have applied accessibility statements on their websites as regulated by law. A descriptive study using a mixed methods approach was conducted, by quantitative descriptive data analysis of the healthcare providers’ accessibility statements compliance to requirements and qualitative data analysis of the written information provided in the accessibility statement. All but one of the 37 evaluated healthcare providers published an accessibility statement. None of the healthcare providers fully met the requirements for accessibility statements, and no one complied with the intention of the law, i.e. to provide accessible health information and eHealth services. There was no or minor progress between the first and the latest published accessibility statement. The possibility to declare no or partial compliance with the law, or claim disproportionate burden, and the lack of enforcement procedures, risk producing symbolic actions e.g., publishing accessibility statements without intention to abide by the law. We suggest that the directives for accessibility statements should be advanced regarding comprehensiveness, understandability, and usefulness. It is suggested that the assessment protocol developed for this study may be used for future evaluations of accessibility statements.
Visible and near-infrared spectroscopy predicted leaf nitrogen contents of potato varieties under different growth and management conditions
Authors: Rawal Ashmita , Hartemink Alfred , Zhang Yakun , Wang Yi , Lankau Richard A. , Ruark Matthew D. 
Published: November 2023

AbstractVisible-Near Infrared (vis-NIR) spectroscopy can provide a faster, cost-effective, and user-friendly solution to monitor leaf N status, potentially overcoming the limitations of current techniques. The objectives of the study were to develop and validate partial least square regression (PLSR) to estimate the total N contents of fresh and removed leaves of potatoes using the vis-NIR spectral range (350–2500 nm) generated from a handheld proximal sensor. The model was built using data collected from Hancock Agricultural Research Station, WI, USA in 2020 and was validated using samples collected in 2021 for four different conditions. The conditions included two sites (Coloma and Hancock), four potato varieties (Burbank, Norkotah, Goldrush, and Silverton), two N rates (unfertilized and 308 kg N ha−1), and four growth stages (vegetative, tuber initiation, tuber bulking, and tuber maturation). The calibration and validation models had high predictive performance for leaf total N with R2 > 0.8 and RPD > 2. The model accuracy was affected by the total N contents in the leaf samples where the model underpredicted the samples with total leaf N contents greater than 6%.
Anti-fibrotic Effect of Oral Versus Intraperitoneal Administration of Gold Nanoparticles in Hepatic Schistosoma mansoni-Infected Mice
Authors: Ahmed Shahira Abdelaziz Ali , Gad Samer Eid Mohamed , Eida Omima Mohamed , Makhlouf Laila Mohamed 
Published: November 2023

Abstract
Background
Schistosomiasis significantly impacts public health, as it causes severe morbidity. Infections caused by Schistosoma mansoni (S. mansoni) can be treated with gold nanoparticles (AuNPs). This study aims to determine the most effective route of AuNPs administration and the magnitude of its anti-fibrotic effect.

Methods
In the five groups' in vivo assay design, AuNPs were administered intraperitoneally (1 mg/kg) and orally (1 mg/100 g) to S. mansoni-infected mice. Biochemical parameters (serum levels of albumin and liver enzymes alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured. The histological changes of the liver in distinct groups were evaluated using Hematoxylin and Eosin, Masson's trichrome, and immunohistochemical stains.

Results
Infection with S. mansoni was associated with substantial changes in the histological architecture of liver tissue and abnormal levels of hepatic function tests (albumin, AST, and ALT). Schistosoma infected hepatocytes exhibited an abnormal microscopic morphology, granuloma formation and aggressive fibrosis. AuNPs restored the liver histological architecture with a highly significant anti-fibrotic effect and significantly corrected hepatic function test levels. Intraperitoneal administration of AuNPs resulted in the most significant anti-fibrotic effect against hepatic S. mansoni infection as observed in all histological sections with Masson's trichrome being the best stain to represent this fact.

Conclusion
For treating S. mansoni-induced chronic liver fibrosis, intraperitoneal administration of AuNPs is a successful and effective route of administration that can be recommended.
Immersion of complete digraphs in Eulerian digraphs
Authors: Girão António , Letzter Shoham 
Published: November 2023

AbstractA digraph G immerses a digraph H if there is an injection f: V(H) → V(G) and a collection of pairwise edge-disjoint directed paths Puv, for uv ∈ E(H), such that Puv starts at f(u) and ends at f(v). We prove that every Eulerian digraph with minimum out-degree t immerses a complete digraph on Ω(t) vertices, thus answering a question of DeVos, McDonald, Mohar and Scheide.
Effectiveness of Telehealth Social Communication Intervention on Language Skills Among Children with Autism Spectrum Disorder: a Systematic Review and Meta-analysis
Authors: Hao Ying , Du Yao , Zhang Saijun , Sun Lin , Keene Gina , Ikuta Toshikazu 
Published: November 2023

AbstractThis systematic review and meta-analysis evaluated the effectiveness of telehealth social communication intervention on language skills of children with autism spectrum disorder (ASD). Twenty-one studies were included, among which 17 were single subject experimental design (SSED). Language outcomes were categorized into five linguistic domains (phonology, morphology, syntax, semantics, and pragmatics), and meta-analysis was planned for each domain. Meta-analysis was only performed for pragmatic outcomes, due to the small number of studies that included outcomes in other domains. The results showed significant pre- to post-intervention improvement, thus supporting the use of telehealth social communication intervention to improve pragmatic skills among children with ASD. More diverse measures should be used to target linguistic domains beyond pragmatics. The predominant use of SSED warrants large-scale studies for robust evidence in the future.
Verluste verzeichnen
Authors: von Contzen Eva 
Published: November 2023

ZusammenfassungAusgehend von Judith Schalanskys Verzeichnis einiger Verluste (2018) nimmt der Beitrag die frappierende Präsenz von Listen und enumerativen Strukturen in der Gegenwartsliteratur in den Blick. Als ein poetisches Prinzip sind listenhafte Formen oftmals Ausdruck einer Defamiliarisierung des Alltäglichen, das dadurch eine Aufwertung erfährt, und verhandeln darüber hinaus existenzielle Fragen.
Fast approximation methods for credit portfolio risk calculations
Authors: Jakob Kevin , Churt Johannes , Fischer Matthias , Nolte Kim , Okhrin Yarema , Sondermann Dirk , Wilke Stefan , Worbs Thomas 
Published: November 2023

AbstractCredit risk is one of the main risks financial institutions are exposed to. Within the last two decades, simulation-based credit portfolio models became extremely popular and replaced closed-form analytical ones as computers became more powerful. However, especially for non-homogenous and non-granular portfolios, a full simulation of a credit portfolio model is still time consuming, which can be disadvantageous within some use cases like credit pricing or within stress testing situations where results must be available very quickly. For this purpose, we investigate if methods based on artificial intelligence (AI) can be helpful to approximate a credit portfolio model. We compare the performance of AI-based methods within three different use cases with suitable non AI-based regression methods. As a result, we see that AI-based methods can generally capture portfolio characteristics and speed-up calculations but - depending on the specific use case and the availability of training data - they are not necessarily always the best choice. Particularly, considering the time and costs for collecting data and training of the complex algorithms, non-AI-based methods can be as good as or even better than AI-based ones, while requiring less computational effort.
ProvSec: Open Cybersecurity System Provenance Analysis Benchmark Dataset with Labels
Authors: Shrestha Madhukar , Kim Yonghyun , Oh Jeehyun , Rhee Junghwan , Choe Yung Ryn , Zuo Fei , Park Myungah , Qian Gang 
Published: November 2023

AbstractSystem provenance forensic analysis has been studied by a large body of research work. This area needs fine granularity data such as system calls along with event fields to track the dependencies of events. While prior work on security datasets has been proposed, we found a useful dataset of realistic attacks and details that are needed for high-quality provenance tracking is lacking. We created a new dataset of eleven vulnerable cases for system forensic analysis. It includes the full details of system calls including syscall parameters. Realistic attack scenarios with real software vulnerabilities and exploits are used. For each case, we created two sets of benign and adversary scenarios which are manually labeled for supervised machine-learning analysis. In addition, we present an algorithm to improve the data quality in the system provenance forensic analysis. We demonstrate the details of the dataset events and dependency analysis of our dataset cases.