bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice
Authors: Le Kim Oanh , Ly Hai Trieu , Le Van Minh 
Published: November 2023

Abstract
Ensete glaucum seeds, being known as one of traditional medicine, are commonly used in folk medicine to treat urinary stones, edema, and osteoarthritis-related problems. However, no scientific evidence has been reported to support these uses. This study focused on investigating the antinociceptive and antiurolithiatic activities of E. glaucum seed aqueous extract (EGE). The antinociceptive effect of EGE was evaluated in mice using thermal (hot plate test) and chemical (acetic acid and formalin-induced nociception test) pain models at various doses (50, 100, 200, 400 mg/kg; p.o.). The anti-urolithiatic activity of the EGE (200, 400 mg/kg; p.o.) was assessed in the sodium glyoxylate-induced urolithiasis in mice and in vitro nucleation and aggregation assays. The analgesic effect of EGE was detected at several doses via peripheral and central antinociceptive mechanisms in the acetic acid-induced writhing (50-400 mg/kg), hot plate (100-200 mg/kg), and formalin-induced licking (200-400 mg/kg) tests. EGE had potential against urolithiasis through its ability to modify several serum and urine biochemical parameters on glyoxylate-induced nephrolithiasis. The extract at the dose of 400 mg/kg significantly improved the inflammatory cells, kidney tissue structure, and renal calcification. The extract also exhibited significant anti-urolithiatic, anti-inflammatory, and antioxidant activities in some in vitro models. These outcomes suggest that E. glaucum aqueous seed extract possesses antinociceptive activity and may aid in the prevention of urinary stones. Further studies are needed to elucidate the effectiveness of E. glaucum seeds in the analgesic activity and management of urolithiasis disease.
Efficacy of Nicorandil in Preventing Contrast-Induced Nephropathy in Patients with ST-segment Elevation Myocardial Infarction undergoing Primary Percutaneous Coronary Intervention
Authors: QIAN GENG , Chen Si , Jiang Xiao-si , Zhang Ying , A Xin , Li Ping , Chen Yun-dai 
Published: November 2023

Abstract
Objective: It is widely reported that nicorandil could reduce contrast-induced nephropathy (CIN) after selective percutaneous coronary intervention (PCI) or coronary angiography. The aim of this multi-center prospective randomized controlled trial is to evaluate the efficacy of nicorandil for the prevention of CIN after primary PCI in patients with ST-segment elevation myocardial infarction (STEMI).
Methods: Patients with STEMI received primary PCI were enrolled, and they were randomly assigned into nicorandil group and placebo group, receiving intravenous nicorandil or placebo before PCI, respectively. The endpoint was the incidence of CIN, defined as an absolute increase in serum creatinine (SCr) > 0.5 mg/dl or a relative increase > 25% compared with baseline SCr. The secondary endpoints were major adverse cardiovascular events (MACEs) within a year.
Results: The final study population comprised 238 randomized patients, and 226 of them (n=113 for each group) were included in the primary analysis. Compared with the placebo group, the final TIMI grade in the nicorandil group was significantly better (P = 0.001), and the incidence of CIN in nicorandil group was significantly lower (9.7% (11/113) vs. 24.8% (28/113), P = 0.003). The logistic regression analysis revealed that nicorandil was significantly associated with the decreased odds of CIN (OR: 0.379, 95% CI: 0.166-0.861, P=0.021). Nicorandil is an independent protective factor for the development of CIN in STEMI patients undergoing primary PCI.
Conclusions: Our study indicated that intravenous nicorandil could prevent CIN in patients with STEMI undergoing primary PCI.
The Impact of Folic Acid/VB12 Deficiency on Essential Hypertension in Children and Adolescents: from a Nested Case-control and a Cohort Study
Authors: Liang xiaohua , He Yun , Hu Guomin , Tong Jishuang , Ren Yanling , Chen Lan , Wang Yuwei , An Xizhou , Jiang Xiaoping , Tahir Muhammad Fahad , Bi Yang , Liu Qin 
Published: November 2023

Abstract
Aims
To explore the relationship between serum folic acid (FA) or Vitamin B12 (VB12) and elevated BP in children and adolescents.
Methods
A nested case-control study was conducted to select 326 subjects (116:210) from an established cohort. And a cohort study was also conducted, which included 270 participants without hypertension at baseline and followed in 2019. Questionnaires, physical examinations, and blood biochemical tests were performed at baseline and follow-up. The relationships between FA, VB12, and blood pressure (BP) levels /elevated BP in children and adolescents were investigated using both a nested case control and a cohort study.
Results
FA and VB12 levels were lower in the elevated BP group than in the control group, and homocysteine levels were higher than that in the control group. In the elevated BP group, overweight/obese children had lower FA than overweight/obese children in the control group. FA was positively correlated with high-density lipoprotein (HDL) and Apo lipoprotein A (APOA), but negatively correlated with triglyceride (TG). FA was significantly correlated with elevated BP in children and adolescents (β=-0.353, P = 0.032), after adjusting VB12, and homocysteine (HCY), and the interaction effect of FA*HCY was significant. Both systolic and diastolic BP levels were statistically lower in the FA high exposure group than in the FA low exposure group in the cohort study.
Conclusions
This study found that FA deficiency in childhood was correlated with elevated BP levels, which may affect BP by regulating lipid levels, and confirmed the importance of FA supplementation in childhood.
Surface mining identification and ecological restoration effects assessment using remote sensing method in Yangtze River watershed, China
Authors: Xu Suchen , Wang Kechao , Xiao Wu , Tong Tong , Sun Hao , Li Chong 
Published: November 2023

Abstract
Mineral resource development is necessary for economic growth, but its negative impacts on land, ecology, and the environment are significant and cannot be ignored. Identification the mine restoration process in a large scale is challenging without specific mining location information. Besides, how to quantitatively evaluates the ecological restoration effects became important for management and supervision. Here, we propose a systematic workflow that utilizes open-source remote sensing data to identify and assess large-scale surface mining areas' restoration status and ecological quality without prior knowledge of mine locations, and implemented in Yangtze River region, the largest watershed area in China. The process includes: (1) extracting surface mining areas using masking, morphological operations, and visual interpretation techniques; (2) constructing time-series of Bare Surface Percentage (BSP) for each mining area on the Google Earth Engine platform to distinguish between abandoned and active mines and examine their restoration rates; (3) constructing the Remote sensing Ecological indicator for Mining areas (REM) to quantify ecological quality and its temporal changes. The results show that: (1) the proposed method effectively identifies surface mining areas with higher boundary delineation accuracy and smaller omission numbers; (2) a total 1,183 mine sites were identified in the study area, of which 381 abandoned mines showed a significant decreasing trend in BSP from 2016 to 2021, with a median decreasing from 98% in 2016 to 81% in 2022, indicating better vegetation recovery during this period. (3) the REM of abandoned mines generally showed a stable upward trend from 2016 to 2022, and vice versa. This study provides a systematic solution for identifying surface mining areas and monitoring restoration scope and ecological quality on a broader scale. It can be extended to other areas and support further ecological restoration decision-making.
Capillary Skimming Floating Microplastics via a Water-Bridged Ratchet
Authors: Kim Seong Jin , Cho Seohyun , Park Sang Jin , Lee Young Jin , Lee You Jun , Lee Young A , Kim Ho-Young , Chung Seok , Moon Myoung-Woon 
Published: November 2023

Abstract

Floating microplastics (MPs) have recently become a major concern in marine pollution; however, current filter-based technology is hardly effective for directly removing such MPs from the water surface because of specific mesh size and clogging issues. This paper introduces a new skimming concept for removing floating MPs utilizing capillary force mediated by the elevation of a hydrophilic ratchet at the air − water interface. MPs floating near the ratchet surface are spontaneously forced toward the ratchet with a concave water meniscus, driven by the Cheerios effect. The MPs can then be skimmed and temporarily held by the deforming concave water meniscus as the ratchet rises. Here, it is found that the stability of the water bridge plays a crucial role in skimming success because it provides capillary adhesion between the MP and the ratchet. The proposed capillary skimming method is demonstrated to be effective across nearly all types of floating MPs, ranging in size from 1 µm to 4 mm, and with densities varying from 0.02 to 0.97 g/cm³, which is also demonstrated by a prototype water-bridged ratchet drum.
Land Use Land Cover Change Detection using remote sensing Indices in Rasik Beel Wetland, West Bengal, India.
Authors: DEBNATH MANOJ , Alam Md. Khurshid , Islam Nazrul , Hossain Saddam , Sarkar Bappa , Roy Ranjan 
Published: November 2023

Abstract
Land use and land cover changes are critical in understanding the dynamics of the environment and its impact on human livelihoods. The Normalized Difference Vegetation Index (NDVI) and Modified Normalized Difference Water Index (MNDWI) are commonly used remote sensing techniques to detect the changes in LULC.Rasik Beel is a wetland and a popular eco-tourism destination located in the Koch Bihar district of West Bengal, which faced rapid alteration of LULC.This study aims to utilize GIS tools to detect the temporal changes in the pattern of Rasik Beel wetlands from 1991 to 2021 to promote sustainable resource management practices.The analysis reveals notable changes in land use and land cover (LULC) in Rasik Beel over the last 30 years, particularly the conversion of 1284.42 hectares of cropland to vegetation. Furthermore, the findings demonstrate that the water surface area in Rasik Beel has experienced fluctuations over time, with a significant decline in shallow water areas that have been transformed into non-water surfaces.Moreover, the findings could assist in sustainable resource management by providing the needed information.
Schistosoma japonicum complex: relatedness of parasites and relatedness of its intermediate hosts in evolution
Authors: Nelwan Martin 
Published: November 2023

Abstract
Purpose: In this research, I report the relationship between S. ovuncatum, S. sinensium, S. japonicum, S. mekongi, and S. malayensis. Additionally, I also report the kinship relationship between five species of Oncomelania with Neotricula aperta, Robertsiella spp, and Tricula spp. Furthermore, I describe the formation of the genus Oncomelania from its predecessor forms.
Principal Results: The results of nucleotide BLAST showed that S. ovuncatum shared a 99.69% identity with S. sinensium, 98.68% identity with S. mekongi, 97.98% identity with S. malayensis, and 97.85% identity with S. japonicum. The tree-view slanted cladogram showed that S. sinensium is a sister to S. ovuncatum. It split into S. japonicum. Schistosoma japonicumsplits into S. mekongi and S. malayensis. The results also showed that Oncomelania robertsoni shared 86.12% identity with Neotricula aperta, 85.88% identity with Robertsiella spp., and 85.28% identity with Tricula bollingi. The tree-view slanted cladogram showed that Tricula spp. split into N. aperta and Robertsiella spp. This study showed that Oncomelania emerged from its predecessor forms.
Conclusions: Nucleotide BLAST results showed that S. ovuncatum is close to S. sinensium. Schistosoma sinensium split into S. japonicum, S. mekongi, and S. malayensis. Oncomelania robertsoni was closer to N. aperta than to Robertsiella spp., and Tricula spp. (Tricula bollingi). Oncomelania species emerged from their predecessor forms.
Towards quantifying (meta-)stability of multi-principal
element alloys: from configurational entropy to
characteristic temperatures
Authors: Zhang Yanhui , Zhou Yunkai , Dong Lisheng , Wang Li-Min , Liu Riping , Sanvito Stefano 
Published: November 2023

Abstract
Understanding the thermodynamics of multi-principal-element alloys (MPEAs), although crucial for their design, remains an elusive task. The configurational entropy, Sconf, is a critical thermodynamic quantity determining stability, but its calculation for real materials poses a hard computational challenge. Strong of a highly efficient cluster expansion, constructed on density functional theory data,and of an advanced sampling technique, we are able to compute Sconf over the huge configurational and compositional space of the prototype bcc Ti-Zr-Hf-Nb-Ta system. In particular, we explore around 200,000 atomic arrangements across more than 200 compositions. The main features of the computed Sconf-vs-temperature curves can be captured by the definition of two characteristic temperatures, which are then used to define a dimensionless descriptor. This, together
with Sconf, enable us to rank alloys according to their (meta-
)stability across a broad composition range, going from equiatomic to nonequiatomic, and even to the regions covered by conventional alloys. Such classification is informed and validated against hundreds of experimental results. Our analysis allows us to revise the classification scheme of alloys into high-entropy, medium-entropy and low-entropy and, in general, sheds light into the thermodynamic origin of their metastability, ultimately helping in the design and development.
Childhood growth of singletons conceived following assisted reproductive technology - does gonadotropin stimulation matter?
Authors: Minger Mirja Amadea , Sommer Grit , Mitter Vera Ruth , Purtschert Livia Amanda , von Wolff Michael , Schwartz Alexandra Sabrina Kohl 
Published: November 2023

Abstract
Purpose: To investigate whether gonadotropin stimulation influences growth or weight gain of children conceived following assisted reproductive technology.Methods: We conducted a single-center, prospective cohort study (2010–2017) including children (n = 139) born after natural-cycle intracytoplasmic sperm injection (NC-ICSI) or conventional gonadotropin stimulated intracytoplasmic sperm injection (c-ICSI) treatment. Growth parameters up to 24 months were collected. Standard deviation scores based on growth references were calculated.Results: The median birth weight in NC-ICSI children was 3.4kg (0.1 standard deviation score (SDS)) compared to 3.3kg (-0.3 SDS) in c-ICSI children (p = 0.61). Median length at birth was 50cm in both groups (NC-ICS (-0.5 SDS), c-ICSI children (-0.8 SDS), p = 0.48). At age 24 months, median weight in NC-ICSI children was 12.2kg (0.3 SDS) versus 12.2kg (0.2 SDS) in c-ICSI children (p = 0.82) and median length 87.5cm (0.1 SDS) versus 88.0cm (0.4 SDS) (p = 0.43).Conclusion: We found no difference in growth between children conceived after stimulated and unstimulated ICSI. Growth parameters of both treatment groups did not differ from Swiss national growth references. One of the main limitations of our study was the small sample size (N = 139) and the high drop-out rate of 49% (68/139).
A comparative assessment of five precipitation products in the Saharan desert of Morocco: Sakia El Hamra basin case study
Authors: El-Alaouy Nafia , GOUMI Said EL , LAFTOUHI Nour-Eddine , Lahrouni Abderrahmane , Bouras El Houssaine , Amazirh Abdelhakim , Gouzrou Abdeljalil 
Published: November 2023

Abstract

The Sakia El Hamra basin, located in the Saharan region of southern Morocco, presents risks of sudden and devastating floods despite a generally arid climate. In this complex hydro-climatic context, the accurate estimation of rainfall is of paramount importance for the management of water resources and flood forecasting. However, the low density of rain gauges networks as well as the rugged topography of the Saharan Atlas, limit the knowledge of rainfall regimes. This study aims to evaluate the performance of five satellite precipitation products (GPM IMERG, TRMM 3B42, ERA5, PERSIANN and CHIRPS) compared to monthly observations from two weather stations (Laayoune and Essmara) over the period 2001–2017. The results reveal notable differences between the satellite products. On a monthly scale, the GPM IMERG product has the best overall accuracy with a mean square error (MSE) of 16.8 mm/month. However, TRMM 3B42 shows better temporal correlations with correlation coefficient (CC) of about 0.83. On an annual scale, TRMM 3B42 performed better than other products with the highest accuracy.
All-Photon Bipolar Reversible Modulation Artificial Synapse for Color Perception and Mitigation of Glare Phenomenon
Authors: Dai Haitao , Fu Yikai , Li Jia , Wang Changlei , Zhao Dewei , Zhang Xiaoli , Liu Changlong , Lv Qieni , Wang Yong , Xiao Yin , Feng Shouzhong 
Published: November 2023

Abstract
The focus of artificial synaptic device researches has gradually shifted towards synaptic devices with specific functionalities. In this work, we report an optically responsive memristor (with a configuration of Ag:AgI/MA0.4FA0.6PbI3/Ag:AgI) that achieves bidirectional switching of resistive states utilizing 450 nm and 650 nm light at an ultra-low readout voltage of 0.001 V. The device presents artificial visual synapses (AVS) features in terms of short-term plasticity (STP)/long-term plasticity (LTP) to pulsed light in the range of 300-700 nm. Under 450 nm blue light, an abrupt shift from low to high resistance can be observed, resembling the effect of glare. Intriguingly, the introduction of 650 nm red light can expedite the recovery following blue light exposure. These attributes underscore potential of the device for tasks encompassing color recognition, memory functions, and adaptation, suggesting promising prospects within artificial visual neural networks for ultraviolet and visible light sensing, transmission, and memory applications.
Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation.
Authors: terskikh Alexey , Alvarez-Kuglen Martin , Rodriguez Delany , Qin Haodong , Ninomiya Kenta , Fiengo Lorenzo , Farhy Chen , Hsu Wei-Mien , Havas Aaron , Feng Gen-Sheng , Roberts Amanda , Anderson Rozalyn , Serrano Manuel , Adams Peter , Sharpee Tatyana 
Published: November 2023

Abstract

Biomarkers of biological age that predict the risk of disease and expected lifespan better than chronologi-cal age are key to efficient and cost-effective healthcare1–3. To advance a personalized approach to healthcare, such biomarkers must reliably and accurately capture individual biology, predict biological age, and provide scalable and cost-effective measurements. We developed a novel approach – image-based chromatin and epigenetic age (ImAge) that captures intrinsic progressions of biological age, which readily emerge as principal changes in the spatial organization of chromatin and epigenetic marks in single nuclei without regression on chronological age. ImAge captured the expected acceleration or deceleration of bio-logical age in mice treated with chemotherapy or following a caloric restriction regimen, respectively. Im-Age from chronologically identical mice inversely correlated with their locomotor activity (greater activity for younger ImAge), consistent with the widely accepted role of locomotion as an aging biomarker across species. Finally, we demonstrated that ImAge is reduced following transient expression of OSKM cassette in the liver and skeletal muscles and reveals heterogeneity of in vivo reprogramming. We propose that Im-Age represents the first-in-class imaging-based biomarker of aging with single-cell resolution.
Developing a clinical judgment model-based online education program for palliative wound care in nursing homes: A quasi-experimental study
Authors: Lee Ye-Na , Kim Dayeong , Choi Young-Rim , Park Won Hee , Kwon Dai-Young , Chang Sung Ok 
Published: November 2023

Abstract
Background
Many issues when combined can make wound management complicated, including the types of wounds and symptoms most commonly affecting palliative care residents and the presence of concurrent comorbidities and their associated treatment in nursing homes. In those complex situations, a nursing staff's clinical judgment is essential for effective decision-making. This study aimed to (1) develop an e-learning program using the clinical judgment model to enhance clinical decision-making competencies and (2) examine the effectiveness of the developed education program.
Methods
In Step 1, developing the program, the characteristics of the learners and the necessary educational content were identified through qualitative interviews. Subsequently, the program was designed and created by considering the educational goals and content identified in the interviews. In Step 2, evaluating the program, its effectiveness was assessed using a quasi-experimental nonequivalent pretest-posttest design. The participants (n = 52) were randomly allocated into an experimental group (n = 26) and a control group (n = 26).
Results
The education program was developed based on the analysis of the educational needs suggested by 10 interviewees, who responded to 11 questions covering elements such as noticing, interpreting, responding, and reflecting, all based on the clinical judgment model. The results indicated that the e-learning program significantly improved clinical judgment in the experimental group compared to the control group (p < 0.01).
Conclusions
This study developed an e-learning program for palliative wound care and assessed its impact on the clinical judgment of nursing staff in nursing homes. The results are expected to enhance palliative wound care competency and contribute to more effective nursing care for residents in nursing homes.