bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dose-response effect of aerobic exercise on inflammation in colon cancer survivors
Authors: Brown Justin C. , Compton Stephanie L.E. , Meyerhardt Jeffrey A. , Spielmann Guillaume , Yang Shengping 
Published: December 2023

BackgroundPhysical activity after surgical resection for colon cancer is associated with significantly longer disease-free survival. Inflammation is hypothesized to mediate the association between physical activity and disease-free survival in colon cancer.MethodsIn this exploratory analysis of a randomized dose-response trial, 39 colon cancer survivors who completed standard therapy were stratified by cancer stage and randomized in a 1:1:1 ratio to one of three treatment groups for 24 weeks of usual-care control, 150 min/wk of moderate-intensity aerobic exercise (low-dose), or 300 min/wk of moderate-intensity aerobic exercise (high-dose). Inflammation outcomes included high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL6), and soluble tumor necrosis factor-alpha receptor 2 (sTNFαR2). Mixed models for repeated measures were used to test the hypothesis that exercise was associated with dose-response reductions in inflammation; exploratory analyses examined treatment effects by cancer stage.ResultsIn the overall population, aerobic exercise was not associated with dose-response reductions in hs-CRP, IL6, or sTNFαR2. Cancer stage modified the association between randomized group and hs-CRP (P=0.022) and IL6 (P&lt;0.001) but not sTNFαR2 (P=0.39). In stage I-II disease, compared to control, exercise was not associated with inflammation outcomes. In stage III disease, compared to control, low-dose exercise reduced hs-CRP: −35.4% (95% CI: −70.1, −0.7) and IL6: −29.6% (95% CI: −58.4, −0.8) but not sTNFαR2: 2.7% (95% CI: sTNFαR2: −15.7, 21.1); high-dose exercise was not associated with inflammation outcomes in stage III disease.ConclusionThis exploratory analysis offers preliminary data to support the hypothesis that inflammation may mediate the association between physical activity and disease-free survival in colon cancer.Clinical trial registrationclinicaltrials.gov, identifier NCT02250053.
Efficacy and safety of combination therapy with pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis
Authors: Huh Jin-Young , Lee Jae Ha , Song Jin Woo 
Published: December 2023

Background: Recent studies have suggested that combination therapy with pirfenidone and nintedanib is safe and tolerable in patients with idiopathic pulmonary fibrosis (IPF). However, data from real-world practice are limited. Thus, we aimed to investigate the safety and efficacy of this combination therapy in patients with IPF in a real-world setting.Methods: A multicenter retrospective cohort study was conducted to investigate the safety and efficacy of combination therapy with pirfenidone and nintedanib in 45 patients with IPF. Incidences of adverse events and rates of lung function decline were compared before and after the combination therapy. Propensity score matching was performed to compare the outcomes between the combination and monotherapy groups.Results: The mean age of the patients was 68.8 years, and 82.2% of them were male. The median follow-up duration after combination therapy was 12.1 months. The majority of the patients (97.8%) received nintedanib as an add-on to pirfenidone. The most common adverse events after the combination therapy were diarrhea and anorexia. Pirfenidone or nintedanib was stopped in 12 patients owing to gastrointestinal AEs, lung transplantation, or financial problems. In patients with serial lung function data, the rate of decline in the forced vital capacity was significantly reduced after the combination therapy. In the matched analysis, the combination group had a higher incidence of diarrhea than the monotherapy group without an increase in serious adverse events; however, the two groups had similar changes in forced vital capacity (FVC).Conclusion: The combination of pirfenidone and nintedanib in patients with IPF has the potential to reduce the rate of FVC decline. However, in the matched analysis, FVC decline was comparable between the patients on combination therapy and those on monotherapy. The incidence of certain adverse events, particularly diarrhea, was higher with combination therapy, but serious adverse events were similar between the groups.
Hybrid treatment verification based on prompt gamma rays and fast neutrons: multivariate modelling for proton range determination
Authors: Schellhammer Sonja M. , Meric Ilker , Löck Steffen , Kögler Toni 
Published: December 2023

Robust and fast in vivo treatment verification is expected to increase the clinical efficacy of proton therapy. The combined detection of prompt gamma rays and neutrons has recently been proposed for this purpose and shown to increase the monitoring accuracy. However, the potential of this technique is not fully exploited yet since the proton range reconstruction relies only on a simple landmark of the particle production distributions. Here, we apply machine learning based feature selection and multivariate modelling to improve the range reconstruction accuracy of the system in an exemplary lung cancer case in silico. We show that the mean reconstruction error of this technique is reduced by 30%–50% to a root mean squared error per spot of 0.4, 1.0, and 1.9 mm for pencil beam scanning spot intensities of 108, 107, and 106 initial protons, respectively. The best model performance is reached when combining distribution features of both gamma rays and neutrons. This confirms the advantage of hybrid gamma/neutron imaging over a single-particle approach in the presented setup and increases the potential of this system to be applied clinically for proton therapy treatment verification.
Predation evaluation of the green lacewing, Chrysopa pallens on the pink tea mite pest, Acaphylla theae (Watt) (Acarina: Eriophyidae)
Authors: Wang Qian , Zhang Meng , Guo Qiuyu , Wu Chenxin , Sun Liang 
Published: December 2023

A better understanding of predator-prey interactions is crucial for the development of biological control strategies. The green lacewing, Chrysopa pallens, is a well-known generalist predator and reportedly functions as one of the most important biological control agents of insect pests. However, information regarding C. pallens’ predation on tea plant pests, particularly notorious tea mites, remains largely unknown. In this study, we focused on the predator-prey relationship between C. pallens and an important tea mite pest, Acaphylla theae. We designed species-specific primers for the detection of A. theae DNA and established a PCR-based DNA gut content analysis assay. These results demonstrated that the primers were A. theae-specific and suitable for its molecular identification. The laboratory feeding experiment showed that the detectability success (DS50) of A. theae DNA remaining in C. pallens’ guts was 2.9 h. We then performed a molecular detection of field predation, and achieved a 23.53% positive detection rate of A. theae DNA in the guts of field-collected C. pallens. This, for the first time, provides direct evidence that C. pallens can prey on A. theae in tea plantations. Finally, we tested the prey preference and estimated the predation ability of C. pallens on different developmental stages of A. theae. The results revealed that C. pallens had no significant preference for different developmental stages of A. theae. The functional responses of C. pallens’ predation on different densities of A. theae at different developmental stages followed a Type II Holling model. The initial attack rate (a’) ranged from 0.735 to 0.858 and the handling time (Th) was approximately 0.01. This study is the first to demonstrate the trophic interactions between C. pallens and A. theae and provides evidence for the development of biological control strategies against A. theae using C. pallens as a candidate predator.
The impact of internet adaptability on internet addiction: the serial mediation effect of meaning in life and anxiety
Authors: Wang Weijun , Ma Shihao , Han Xinheng , Zhao Xin 
Published: December 2023

IntroductionPrevious research has demonstrated the significant role of individual characteristics in adolescent Internet addiction. In line with this, our previous research has introduced the concept of “Internet adaptability” as a potential factor that enables individuals to effectively cope with the negative consequences of Internet use. However, further investigation is required to understand the impact of Internet adaptability on problematic Internet use, including Internet addiction, as well as its associated internal psychological factors. To address this research gap, the present study aims to examine the impact of Internet adaptability on internet addiction and explore the mediating roles of meaning in life and anxiety within this relationship.MethodsA questionnaire was used to survey 2,144 adolescents from high schools in central China to investigate internet adaptability, meaning in life, anxiety, and internet addiction.ResultsThe results revealed a significant negative correlation between Internet adaptability and adolescent internet addiction (r = −0.199, p &lt; 0.01). Furthermore, our results indicated that Internet adaptability negatively predicts internet addiction (β = −0.086, p &lt; 0.001). Additionally, mediation analyses revealed that both meaning in life (β = −0.060, p &lt; 0.001) and anxiety (β = −0.032, p &lt; 0.01) mediate the relationship between Internet adaptability and internet addiction. Moreover, a serial mediation effect involving meaning in life and anxiety was observed between Internet adaptability and internet addiction (β = −0.027, p &lt; 0.001).ConclusionThese findings suggest that Internet adaptability plays an important role in alleviating individual internet addiction. Our results indicate that increasing individuals’ sense of meaning in life can help reduce anxiety, thereby potentially reducing internet addiction.
Health care in future community: innovatively discover and respond to the needs of today’s seniors
Authors: Zhou Bowen , Deng Qidan , Zhou Shiyuan , Zhuo Dongni 
Published: December 2023

IntroductionIn the context of the digital economy, the emergence and application of emerging technologies have accelerated the integration of traditional social structures with new technologies, leading to the inception of the “Future Community” as an innovative urban unit. With an aging population’s rapid and sustained rise, integrating health care for older adults with modern information technology is gradually moving towards holistic governance. This approach utilizes the Future Community as a medium and aims for quality enhancement and increased efficiency, which instrumentally addresses the diversified health care needs of China’s aging era.MethodsIn this study, we employed a questionnaire survey method that covered 11 communities in Tianjin City to understand better the current status and characteristics of their health care services.ResultsThe survey results show that the means of community health care for older adults are gradually being upgraded, and the demands are shifting. Then, we arrive at three conclusions: firstly, technological innovation and smart approaches have the potential to positively influence the quality of health care in these communities. Secondly, allocating health care resources within communities can have a salutary effect on the psychological well-being of seniors. Thirdly, actively involving seniors in community life and governance can elevate their self-worth.DiscussionAt last, in conjunction with current challenges, we think that deepening multi-party collaboration, educating specialized talents, and bridging the “digital gap” would be effective ways to establish a future community for seniors.
Risk factors and injury prevention strategies for overuse injuries in adult climbers: a systematic review
Authors: Quarmby Andrew , Zhang Martin , Geisler Moritz , Javorsky Tomas , Mugele Hendrik , Cassel Michael , Lawley Justin 
Published: December 2023

IntroductionClimbing is an increasingly popular activity and imposes specific physiological demands on the human body, which results in unique injury presentations. Of particular concern are overuse injuries (non-traumatic injuries). These injuries tend to present in the upper body and might be preventable with adequate knowledge of risk factors which could inform about injury prevention strategies. Research in this area has recently emerged but has yet to be synthesized comprehensively. Therefore, the aim of this study was to conduct a systematic review of the potential risk factors and injury prevention strategies for overuse injuries in adult climbers.MethodsThis systematic review was conducted in accordance with the PRISMA guidelines. Databases were searched systematically, and articles were deemed eligible based upon specific criteria. Research included was original and peer-reviewed, involving climbers, and published in English, German or Czech. Outcomes included overuse injury, and at least one or more variable indicating potential risk factors or injury prevention strategies. The methodological quality of the included studies was assessed with the Downs and Black Quality Index. Data were extracted from included studies and reported descriptively for population, climbing sport type, study design, injury definition and incidence/prevalence, risk factors, and injury prevention strategies.ResultsOut of 1,183 records, a total of 34 studies were included in the final analysis. Higher climbing intensity, bouldering, reduced grip/finger strength, use of a “crimp” grip, and previous injury were associated with an increased risk of overuse injury. Additionally, a strength training intervention prevented shoulder and elbow injuries. BMI/body weight, warm up/cool downs, stretching, taping and hydration were not associated with risk of overuse injury. The evidence for the risk factors of training volume, age/years of climbing experience, and sex was conflicting.DiscussionThis review presents several risk factors which appear to increase the risk of overuse injury in climbers. Strength and conditioning, load management, and climbing technique could be targeted in injury prevention programs, to enhance the health and wellbeing of climbing athletes. Further research is required to investigate the conflicting findings reported across included studies, and to investigate the effectiveness of injury prevention programs.Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42023404031).
“I’m going to change the WIFI password if you don't go outside!”: a qualitative examination of changes in parenting practices over the course of the COVID-19 pandemic
Authors: Paterson Derek , Beauchamp Mark R. , Masse Louise C. , Moore Sarah A. , Faulkner Guy 
Published: December 2023

IntroductionParenting practices are an important influence on the movement behaviours of children. Parenting practices are shaped by various contextual factors (e.g., culture, sociodemographic, community) and are susceptible to external pressures, such as health crises like the COVID-19 pandemic. Situated within the revised Family Ecological Model, the purpose of this study was to qualitatively explore changes in parenting practices over time in relation to the evolving nature of this global event.MethodsOne-on-one semi-structured interviews with 40 parents of children (aged 7–11) in three Canadian provinces were conducted in August, 2021. A narrative thematic analysis was conducted to develop themes mapping changes in parenting practices and organize the temporal patterns of these changes into shared case trajectories over time.ResultsFour themes were constructed to highlight changes in parenting practices: (1) Screen time permissiveness, (2) Force and coercion, (3) Agents of unstructured physical activity, and (4) Stepping back from structured physical activity. These themes were organized into three distinct case trajectories that each represent a shared, chronological narrative for how the first 18 months of the pandemic were broadly experienced by parents. The three trajectories were characterized by: (1) Resilience (2) Enduring impact and (3) Adaptive growth.DiscussionParenting practices were changed in response to circumstances in both temporary and enduring manners that may continue beyond the pandemic. Further research is needed to longitudinally assess these trajectories in order to support families and enhance understanding of parenting practices in challenging circumstances.
Screening Bacterial Strains Capable of Producing 2,3-Butanediol: Process Optimization and High Diol Production by Klebsiella oxytoca FMCC-197
Authors: Palaiogeorgou Anastasia Marina , Delopoulos Ermis Ioannis Michail , Koutinas Apostolis A. , Papanikolaou Seraphim 
Published: December 2023

In the present investigation, the potential of various newly isolated strains which belong to the Enterobacteriaceae family to produce 2,3-butanediol (BDO), an important bio-based compound, was studied. The most interesting strain, namely Klebsiella oxytoca FMCC-197, was selected for further investigation. Commercial (raw) sucrose or molasses, which are important agro-industrial surpluses, were employed as carbon sources for most of the trials performed. Different fermentation parameters (viz. incubation te4mperature, utilization of different carbon sources, substrate inhibition, aeration) were tested to optimize the process. Fermentations under non-aseptic conditions were also conducted to investigate the potential of growth of the strain K. oxytoca FMCC-197 to surpass the growth of other microorganisms in the culture medium and produce BDO. Besides BDO production, in trials in which molasses was employed as the sole carbon source, significant color removal was observed simultaneously with the production of microbial metabolites. The very high BDO concentration ≈115 g L−1 was reported in approximately 64 h during a fed-batch bioreactor experiment, using sucrose and molasses as carbon sources at 30 °C, reaching a conversion yield (YBDO) of 0.40 g g−1 and a productivity rate (PBDO) of 1.80 g L−1 h−1, while similar results were also obtained at 37 °C. The strain demonstrated remarkable results in non-previously sterilized media, as it produced 58.0 g L−1 in 62 h during a fed-batch bioreactor experiment, while the potential to decolorize molasses-based substrates over 40% was also recorded. From the results obtained it is shown that this wild-type strain can be used in large-scale microbial BDO production using various raw materials as fermentative substrates. The wastewater derived after BDO fermentation by K. oxytoca FMCC-197 can be disposed relatively safely into the environment.
Secondary Metabolites from the Genus Eurotium and Their Biological Activities
Authors: Deng Jiantianye , Li Yilong , Yuan Yong , Yin Feiyan , Chao Jin , Huang Jianan , Liu Zhonghua , Wang Kunbo , Zhu Mingzhi 
Published: December 2023

Eurotium is the teleomorph genus associated with the section Aspergillus. Eurotium comprises approximately 20 species, which are widely distributed in nature and human environments. Eurotium is usually the key microorganism for the fermentation of traditional food, such as Fuzhuan brick tea, Liupao tea, Meju, and Karebushi; thus, Eurotium is an important fungus in the food industry. Eurotium has been extensively studied because it contains a series of interesting, structurally diverse, and biologically important secondary metabolites, including anthraquinones, benzaldehyde derivatives, and indol diketopiperazine alkaloids. These secondary metabolites have shown multiple biological activities, including antioxidative, antimicrobial, cytotoxic, antitumor, insecticidal, antimalarial, and anti-inflammatory activities. This study presents an up-to-date review of the phytochemistry and biological activities of all Eurotium species. This review will provide recent advances on the secondary metabolites and their bioactivities in the genus Eurotium for the first time and serve as a database for future research and drug development from the genus Eurotium.
Cy Twombly et le dépaysement de l’écriture
Authors: Montégu Frédéric 
Published: December 2023

Dans le travail pictural de Cy Twombly, nous voyons apparaître des éléments récurrents au regard de l’écriture : dessins, griffonnages, traits, mots lisibles ou non. Sans qu’il s’agisse pour autant d’un travail calligraphique, son œuvre picturale est comme imprégnée d’écriture, de verbes, de mots anglais, français, italiens, latins, ou non déterminés. Cy Twombly dit à sa manière que l’essence de l’écriture n’est ni une forme ni un usage, mais seulement un geste, le geste qui la produit en la laissant traîner : « un brouillis, presque une salissure, une négligence » selon Roland Barthes. Dans sa peinture, lorsque l’écriture est visible, elle peut faire référence à la culture antique, à la mythologie, à une ville, un livre, voire à un personnage spécifique. Mais, la surface peut tout aussi bien redevenir écoulement des formes, fluctuations liquides, tâches, gribouillis informes, couleurs et coulures plastiques annihilant tout enjeu linguistique. Comme si ce peintre se situait à la fois dans une apparition / disparition de l’écriture, comme si la peinture redevenait tout d’un coup un pur champ / pan plastique, « all over », comme si la matérialité de la peinture (le signifiant plastique) finissait par engloutir tout signe linguistique.
Paradoxes du dépaysement dans The Shadow Lines d’Amitav Ghosh (1988) : un processus de (dé)familiarisation ?
Authors: Lasorak Natacha 
Published: December 2023

The Shadow Lines (1988), d’Amitav Ghosh, est un récit d’expatriations croisées, comme autant d’expériences de défamiliarisation répétées. Les membres de la famille du narrateur sont en proie à ces déplacements depuis l’exil de sa grand-mère qui, avant la Partition en 1947, quitte Dhaka pour s’installer à Kolkata. Les générations suivantes feront elles aussi l’expérience de l’immigration, dans une errance entre Londres, Kolkata et Dhaka qui convoque la période précédant l’Indépendance de l’Inde mais aussi la Seconde Guerre mondiale, les années 1960 et la fin des années 1970. La notion de dépaysement s’inscrit alors dans un paradoxe : si l’immigration crée des situations de dé-paysement (changement de pays), il semblerait pourtant que les expériences les plus dépaysantes prennent place lors le retour au lieu d’origine (« home »). La division du roman en deux parties, « Going Away » et « Coming Home », suggère que le récit met en scène le retour à un espace familier, au foyer (« home »). Pourtant, le récit du retour est souvent l’expérience d’une défamiliarisation abrupte, qui s’inscrit au sein même du pays et du paysage de l’enfance, comme en témoigne le « homecoming » de la grand-mère du narrateur à Dhaka. À l’inverse, lors de voyages en pays inconnus, alors que les lecteur·rices auraient pu s’attendre à la surprise du dépaysement, les constructions de la mémoire créent un effet de déjà-vu, comme si le paysage était déjà familier, appréhendé par l’histoire et les histoires. Sur le plan narratif et textuel, la fragmentation géographique et chronologique déroutante, qui trouble le paysage du livre, interdit toute linéarité et propose une expérience de dépaysement aux lecteur·rices. Cette présentation s’interrogera sur la façon dont les déplacements du roman subvertissent le sentiment de dépaysement, sans se limiter à l’expérience de dé-paysement (changement de pays).