bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice
Authors: Pelletier Shawn D. , Hong Daniel S. , Hu Yiguo , Liu Yuhua , Li Shaoguang 
Published: June 2004

Abstract
In vitro studies show that BCR/ABL-expressing hematopoietic cells exhibit altered adhesion properties. No in vivo studies show whether the altered adhesion properties affect BCR/ABL leukemo-genesis. Using mice with homozygous inactivation of genes encoding the 2 adhesion molecules P-selectin and intercellular adhesion molecule-1 (ICAM1), we show that the mutant mice develop BCR/ABL-induced chronic myeloid leukemia (CML)-like leukemia at a significantly faster rate than do wild-type (WT) mice. Lack of P-selectin and ICAM1 did not have a significant effect on the development of B-cell acute lymphoblastic leukemia (BALL) induced by BCR/ABL. Using mice deficient for P-selectin or ICAM1 alone, we show that P-selectin plays a major role in the acceleration of CML-like leukemia. Lack of P-selectin resulted in early release of BCR/ABL-expressing myeloid progenitors from bone marrow, appearing to alter the biologic properties of leukemic cells rather than their growth rate by increasing their homing to the lungs, causing fatal lung hemorrhages. These results indicate that adhesion of BCR/ABL-expressing myeloid progenitors to marrow stroma through P-selectin and ICAM1 play an inhibitory role in the development of CML-like disease, suggesting that improvement of adhesion between BCR/ABL-expressing myeloid progenitor cells and bone marrow stroma may be of therapeutic value for human CML. (Blood. 2004;104:2163-2171)
The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors
Authors: Hildbrand Patrick , Cirulli Vincenzo , Prinsen Robyn C. , Smith Kent A. , Torbett Bruce E. , Salomon Daniel R. , Crisa Laura 
Published: June 2004

AbstractCirculating endothelial progenitors contribute to neovascularization at sites of injury and tumorigenesis in postnatal life. Yet, the molecular mechanisms initiating the endothelial developmental program of these precursors remain elusive. Here we provide evidence that endothelial development from progenitors circulating in human cord blood requires angiopoietins, a set of growth factors also involved in vascular branching during embryogenesis. We show that cord blood cells with the potential for endothelial development reside in a CD34+CD11b+ subset capable of autonomously producing and binding angiopoietins. Functionally, endogenous angiopoietin-1 regulates initial endothelial cell commitment, whereas angiopoietin-2 enhances expansion of the endothelial cell progeny. These findings suggest a role for angiopoietins as regulators of endothelial development from circulating progenitors and imply a function of angiopoietins at distinct developmental steps in postnatal angiogenesis.
Unique gene expression program of human germinal center T helper cells
Authors: Kim Chang H. , Lim Hyung W. , Kim Jong R. , Rott Lusijah , Hillsamer Peter , Butcher Eugene C. 
Published: June 2004

AbstractGene expression profiling was used to compare the gene expression patterns of human germinal center (GC) T helper (Th) cells with other CD4+ T-cell subsets (naive, central, and effector memory T cells). GC-Th cells, specifically localized in germinal centers to help B cells, are distantly related to central and effector memory T cells in global gene expression profiles. GC-Th cells displayed substantial differences in mRNA for adhesion molecules, chemoattractant receptors, and cytokines compared with other populations. Distinct expression of transcriptional factors by GC-Th cells is consistent with the hypothesis that they may be different from other T cells in cell lineage. Interestingly, CXCL13, a critical chemokine for B-cell entry to lymphoid follicles, is one of the most highly up-regulated genes in GC-Th cells. GC-Th cells (but not other T cells) produce and secrete large amounts of functional CXCL13 upon T-cell receptor activation, a process that is dependent on costimulation, requires translation and transcription, and is dramatically enhanced by activation in the presence of GC-B cells. This study revealed for the first time the unique gene expression program of GC-Th cells.
Complex Formation and Gelation between Copolymers Containing Pendant Azobenzene Groups and Cyclodextrin Polymers
Authors: Takashima Yoshinori , Nakayama Tomofumi , Miyauchi Masahiko , Kawaguchi Yoshinori , Yamaguchi Hiroyasu , Harada Akira 
Published: June 2004

Abstract
The copolymers of acrylamide and acrylamide with pendant azobenzene (AzBA–AAm) were prepared by radical polymerization. The association constants of trans-AzBA–AAm copolymers with β-CD are larger than those of cis-AzBA–AAm copolymers. The trans-AzBA–AAm guest copolymer was found to form supramolecular gels with β-CD–pAA (pAA; poly(allylamine)) host copolymers in water.
Side Chain Bromination of Mono and Dimethyl Heteroaromatic and Aromatic Compounds by Solid Phase N-Bromosuccinimide Reaction without Radical Initiator under Microwave
Authors: Goswami Shyamaprosad , Dey Swapan , Jana Subrata , Adak Avijit Kumar 
Published: June 2004

Abstract
A series of side chain mono and dibromo derivatives of mono and dimethyl heteroaromatic and aromatic compounds (1–17) were synthesized by one step solid phase N-bromosuccinimide (NBS) reaction without radical initiator by microwave irradiation. The benzylic mono and dibromo products were exclusively preferred except in the case of 6-methylpyridine amides (8 and 9) where nuclear and also side chain bromination resulted. Naphthyridine systems resulted improved yields. By this method, we also report the synthesis of 2-pivaloylaminopterin-6-carbaldehyde.
Total Synthesis of (–)-ent-Jolkinolide D
Authors: Suenaga Kiyotake , Takayanagi Yui , Yamaura Masashi , Kigoshi Hideo 
Published: June 2004

Abstract
The first total synthesis of the enantiomer of jolkinolide D, a bioactive diterpene from Euphorbia jolkini Boiss, was achieved from abietic acid. The enantiomer did not exhibit the biological activities that the natural jolkinolide D possesses.
Synthesis of Aryl-substituted Quinoline Derivatives via Brønsted Acid-catalyzed [4+2] Aza Diels–Alder Reaction
Authors: Akiyama Takahiko , Nakashima Saeko , Yokota Koji , Fuchibe Kohei 
Published: June 2004

Abstract
CF3SO3H-catalyzed [4+2] aza Diels–Alder reaction of aldimines with silyl enol ethers, and subsequent in situ oxidation furnished quinoline derivatives in good to excellent yields, wherein use of CF3SO3H as a Brønsted acid is critical for the cyclization reaction.
Acute Interstitial Nephritis Due to Cefoperazone
Authors: Torun Dilek , Sezer Siren , Kayaselcuk Fazilet , Zumrutdal Aysegul , Ozdemir Fatma N , Haberal Mehmet 
Published: June 2004

OBJECTIVE: To describe a case of cefoperazone-induced acute interstitial nephritis (AIN) in which the diagnosis was supported by renal biopsy. CASE SUMMARY: A 35-year-old woman presented to our hospital with decreased urine output and no past history of renal problems. Fifteen days prior to presentation, she had started treatment with intramuscular cefoperazone 1 g/day for a scalp infection. On day 12 of therapy, the patient noted decreased urine output, anorexia, and weakness, but she continued taking cefoperazone for 3 more days. Hemodialysis and oral prednisolone 1 mg/kg (30 mg twice daily) were started. Renal function returned to normal after 2 months of prednisolone treatment. DISCUSSION: Although AIN has been linked with other cephalosporins, as of June 18, 2004, to our knowledge, this is the first report of a cefoperazone-induced case. We based our diagnosis on the features of acute-onset renal failure, abnormal urinalysis findings, eosinophilia, inflammatory infiltrate in the interstitium, and recovery from renal failure after initiation of corticosteroid treatment. Application of the Naranjo probability scale indicated a probable relationship between the acute renal failure secondary to the possible AIN and cefoperazone therapy in this patient. CONCLUSIONS: This case indicates that cefoperazone, like other cephalosporins, can cause AIN. We recommend close monitoring of renal function in patients who are prescribed this drug.
Überwachung temperaturgeführter Transporte mit Hilfe mobiler Fahrzeugkommunikation (Monitoring of Temperature-critical Transports through Mobile Vehicle-communication)
Authors: Erkens Elmar , Fitsch Marco , Kopfer Herbert , Gräser Axel 
Published: June 2004

Abstract
Der Beitrag stellt die Erweiterung eines speditionellen Kommunikationssystems um ein Modul für die Überwachung temperaturgeführter Transporte vor. Zunächst werden Anforderungen an die Überwachung von Kühltransporten beschrieben. Danach wird das Kommunikationssystem w@pLog vorgestellt, in das die Temperaturüberwachung zu integrieren ist. Abschließend wird das auf Basis der Erfordernisse der temperaturgeführten Transporte und der Fahrzeugkommunikation abgeleitete technische Lösungskonzept erläutert.
Mehrstufige Kapazitäts- und Ablaufplanung in der Mini Factory Diode der Bosch GmbH in Reutlingen (Multi-Stage Capacity Planning and Scheduling in the Mini Factory Diode of Bosch Ltd. in Reutlingen)
Authors: Haase Knut , Pauli Matthias , Soniadis Gabriel 
Published: June 2004

Abstract
Ein komplexes Maschinenbelegungsplanungsproblem in einem Unternehmen der Halbleiterindustrie wird betrachtet. Die Problemstellung ist durch eine divergierende Produktionsstruktur (Mehrstufigkeit), signifikante Rüstzeiten und alternative Maschinenfolgen gekennzeichnet. Gegenstand der Betrachtung sind die beiden letzten Produktionsstufen, d. h. die Montage und die Endmessung. Die Montage ist als Fließfertigung und die Endmessung als Werkstattfertigung organisiert. Besonderheiten der Planung ergeben sich aus festzulegenden Einsatzzeiten der Maschinen und kapazitätsreduzierenden Anlaufzeiten nach einem Maschinenstillstand. Die Problemstellung wird als mehrperiodiges Knapsack-Problem formalisiert. Zur heuristischen Lösung wird ein genetischer Algorithmus vorgeschlagen, der für den praktischen Einsatz in eine menügesteuerte Umgebung eingebunden ist. Durch den Einsatz des in Java implementierten Programms reduziert sich die Planungszeit von mehreren Tagen auf wenige Minuten, wobei die generierten Pläne eine hohe Akzeptanz bei den Planern fanden.
Dezentrale Automatisierungsstrategien für Gepäckbeförderungssysteme (Decentralized Automation Strategies for Baggage Transportation Systems)
Authors: Fay Alexander , Fischer Ivo 
Published: June 2004

Abstract
Wird das Gepäck in Flughäfen mit Hilfe von Einzelfahrzeugen befördert, so stellt die Steuerung der Fahrzeuge eine große Herausforderung für einen zentralen Steuerungsrechner dar. In diesem Beitrag wird ein dezentrales Steuerungskonzept vorgestellt. Dabei werden die Transportaufträge mit einem marktbasierten Verfahren den Fahrzeugen zugewiesen, und das Routing der Fahrzeuge durch das Streckennetz erfolgt ähnlich wie bei den Routing-Mechanismen des Internets.
Sulfotransferasen: Struktur, Mechanismus, biologische Aktivität, Inhibierung, Anwendung in Synthesen
Authors: Chapman Eli , Best Michael D. , Hanson Sarah R. , Wong Chi‐Huey 
Published: June 2004

AbstractSeit langem ist bekannt, dass die Sulfonierung von Biomolekülen in einer Vielzahl von Organismen stattfindet, von Prokaryoten bis hin zu vielzelligen Spezies, und ständig werden neue biologische Funktionen entdeckt, die mit dieser Umsetzung verknüpft sind. Frühe Studien zu Sulfotransferasen (STs), den Enzymen, die Sulfonierungen katalysieren, konzentrierten sich primär auf zytosolische STs, die an Entgiftungsreaktionen, der Hormonregulation und am Wirkstoffmetabolismus beteiligt sind. Obwohl man von ihrer Existenz gewusst hat, wurden membranassoziierte STs bis vor kurzem kaum untersucht. Sie sind an der Sulfonierung komplexer Kohlenhydrate und Proteine beteiligt und spielen eine zentrale Rolle bei einer Reihe von molekularen Erkennungsmechanismen und biochemischen Signalwegen. Des Weiteren hängen STs mit vielen pathophysiologischen Prozessen zusammen. Dies führte zu einem verstärkten Interesse an den komplexen Funktionen von STs und an der Möglichkeit zur Targetierung in therapeutischen Eingriffen. In diesem Aufsatz werden die Fortschritte bei der Aufklärung der Strukturen und Mechanismen von Sulfotransferasen sowie ihre biologische Aktivität, Inhibierung und Anwendung in der Synthese diskutiert.
Non‐kinase second‐messenger signaling: new pathways with new promise
Authors: Springett Gregory M. , Kawasaki Hiroaki , Spriggs David R. 
Published: June 2004

AbstractIntercellular signaling by growth factors, hormones and neurotransmitters produces second messenger molecules such as cyclic adenosine monophosphate (cAMP) and diacylglycerol (DAG). Protein Kinase A and Protein Kinase C are the principal effector proteins of these prototypical second messengers in certain cell types. Recently, novel receptors for cAMP and DAG have been identified. These proteins, designated EPAC (Exchange Protein directly Activated by cAMP) or cAMP‐GEF (cAMP regulated Guanine nucleotide Exchange Factor) and CalDAG‐GEF (Calcium and Diacylglycerol regulated Guanine nucleotide Exchange Factor) or RasGRP (Ras Guanine nucleotide Releasing Protein) are able to mediate some of the physiologic effects of the second messengers in a protein‐kinase‐independent fashion. These proteins are exchange factors for Ras family GTPases that operate in pathways that run parallel to the classic kinase‐dependent pathways. The rapidly emerging recognition of the functions of these “non‐kinase” effectors in diverse processes such as insulin secretion, thymocyte development, asthma and malignant transformation creates new opportunities for discovery and identifies potential new therapeutic targets. BioEssays 26:730–738, 2004. © 2004 Wiley Periodicals, Inc.
Turning back the clock on neural progenitors
Authors: Carr Adrian R. , Choksi Semil P. , Brand Andrea H. 
Published: June 2004

AbstractDrosophila neural progenitor cells, or neuroblasts, alter their transcriptional profile over time to produce different neural cell types. A recent paper by Pearson and Doe shows that older neuroblasts can be reprogrammed to behave like young neuroblasts, and to produce early neural cell types, simply by expressing the transcription factor, Hunchback.1 The authors show that competence to respond to Hunchback diminishes over time. Mani pulating neural progenitors in this way may have important implications for therapeutic uses of neural stem cells. BioEssays 26:711–714, 2004. © 2004 Wiley Periodicals, Inc.
The effects of dietary flaxseed on the Fischer 344 rat: II. liver γ‐glutamyltranspeptidase activity
Authors: Hemmings Susan J. , Westcott Neil , Muir Alister , Czechowicz Dominika 
Published: June 2004

AbstractThe effect of 10% flax chow consumption from the 30th to the 130th day after birth was examined in male Fischer 344 rats. The effects of both the high lignan/high oil Norlin strain and a high lignan/low oil Solin strain of flaxseed were compared. Physically and behaviourally there were no differences in rats belonging to the three dietary groups at any time. At 50 and 100 days of dietary exposure, blood glucose levels were the same in Norlin and Solin flax chow‐fed and as well as regular chow‐fed rats; there were no signs of toxicity in the Norlin and Solin flax‐fed rats since their plasma levels of alanine aminotransferase were the same and equal to those of regular chow‐fed rats. The activity of γ‐glutamyltranspeptidase (γGT) displayed an increase in the liver homogenates of flax chow‐fed rats. This increase was the same in Norlin and Solin flax‐fed rats at 50 and 100 days. Thus the liver effect was not oil, but lignan, likely secoisolariciresinol diglucoside (SDG), induced and was effected early on, and sustained, after flax exposure. The degree of heat activation of liver homogenate γGT was the same in regular chow‐fed and flax chow‐fed rats. Compared to liver homogenate γGT activity, the soluble form of γGT was expressed at very low levels while the plasma membrane‐bound form of γGT was expressed at very high levels in rat liver in both regular chow‐fed and flax chow‐fed rats. There was no effect of flax feeding on the soluble form of liver γGT which was expressed at a very low level. Flax feeding effected an increase in the activity of γGT in isolated plasma membrane fractions which mirrored that in liver homogenates: the same degree of increase was seen in Norlin flax chow‐fed and Solin flax chow‐fed rats. Flax consumption effects an increase in the activity of liver γGT at the level of the plasma membrane which is lignan dependent, physiologically relevant and may be linked to hepatoprotection against injury through an increase in reduced glutathione. Copyright © 2004 John Wiley & Sons, Ltd.
PKU‐5: An Aluminoborate with Novel Octahedral Framework Topology
Authors: Ju Jing , Yang Tao , Li Guobao , Liao Fuhui , Wang Yingxia , You Liping , Lin Jianhua 
Published: June 2004

AbstractA new anhydrous aluminoborate Al4B6O15 (PKU‐5) has been synthesized in a boric acid flux in a closed system at 350 °C. PKU‐5, which crystallizes in the space group R3 with the lattice constants a=11.43398(9) and c=6.48307(5) Å, consists of Al octahedra and triangularly coordinated boron. The Al octahedron adopts the (10,3)‐a network, in which each octahedron shares three edges with the neighboring octahedra forming ten‐membered‐ring channels. The octahedral backbone in PKU‐5 can be considered as a primary octahedral framework topology and, setting out from the structures of the aluminoborates (PKU‐1 and PKU‐5), we propose construction rules for the octahedral frameworks. There are two types of connections for edge‐sharing octahedra in porous frameworks, trans and cis type, by which various microporous octahedral frameworks of different topologies can be constructed. The borate groups share oxygens with the Al octahedral frameworks forming two kinds of three‐membered‐ring units consisting of two octahedra and one triangle (2Al+B) and one octahedron and two triangles (Al+2B), respectively.
Seasoning Materials Chemistry by Using a Well‐Matured Organic Concept
Authors: Yokoyama Yasushi 
Published: June 2004

AbstractThe concept “introduction of allylic 1,3‐strain (A(1,3)‐strain) to photochromism” originated from the experience of total synthesis of natural products about 18 years ago, when the author was a post doc. It was first applied to synthetic organic reactions, then it was successfully employed in the diastereoselective photochromic reactions of diarylethenes. A diastereomeric excess of the photoreaction was 88 % for the first example, and it was improved to 94 % by the recent operation of rational molecular tailoring.
An Industrially Viable Catalyst System for Palladium‐Catalyzed Telomerizations of 1,3‐Butadiene with Alcohols
Authors: Jackstell Ralf , Harkal Surendra , Jiao Haijun , Spannenberg Anke , Borgmann Cornelia , Röttger Dirk , Nierlich Franz , Elliot Mark , Niven Stuart , Cavell Kingsley , Navarro Oscar , Viciu Mihai S. , Nolan Steven P. , Beller Matthias 
Published: June 2004

AbstractThe telomerization reaction of 1,3‐butadiene with alcohols to give alkyl octadienyl ethers in the presence of palladium–carbene catalysts has been studied in detail. Unprecedented catalyst efficiency with turnover numbers (TON) up to 1 500 000 and turnover frequencies (TOF) up to 100 000 h−1 have been obtained after optimization for the reaction of methanol in the presence of an excess of in situ generated carbene ligands. High yields (75–97 %) and catalyst productivities (TON 15 000–100 000) are observed for other aliphatic alcohols and phenols. For comparison five carbene–palladium(0) complexes have been synthesized and characterized by X‐ray crystallography. Both electronic and steric effects on the stability and reactivity of the catalysts have been discussed on the basis of density functional theory calculations.
‘Chemobrain’ in breast carcinoma?
Authors: Wefel Jeffrey S. , Lenzi Renato , Theriault Richard , Buzdar Aman U. , Cruickshank Scott , Meyers Christina A. 
Published: June 2004

AbstractBACKGROUNDChemotherapy‐induced cognitive dysfunction in patients with breast carcinoma has been described previously. However, those studies only assessed patients' postchemotherapy cognitive functioning and were not able to determine the relation between cognitive function and other treatments, such as surgery and radiotherapy, that often precede systemic chemotherapy.METHODSEighty‐four women with breast carcinoma underwent a comprehensive neuropsychologic evaluation before receiving adjuvant therapy for nonmetastatic primary breast carcinoma.RESULTSBefore the start of systemic therapy, 35% of women in the current cohort exhibited cognitive impairment. Verbal learning (18%) and memory function (25%) were impaired significantly more frequently relative to normative expectations. Although the impairments were not significant in the women who were examined, nonverbal memory (17%), psychomotor processing speed and attention (13%), confrontational naming (13%), visuoconstruction (13%), and upper‐extremity fine motor dexterity (12%) were impaired more frequently than was expected. Affective distress was related significantly to cognitive impairment (Pearson chi‐square = 9.90; P = 0.002). Given the conservative statistical approach employed, extent of surgery, hormone replacement therapy history, and current menopausal status failed to achieve statistical significance, but these variables did exhibit provocative trends with respect to cognitive impairment.CONCLUSIONSCognitive impairment frequently is observed before the administration of systemic chemotherapy. Thus, investigations purporting to measure chemotherapy‐induced cognitive dysfunction must employ study designs that incorporate prechemotherapy baseline assessments to accurately detect changes in cognitive function that are attributable to chemotherapy. Cancer 2004. © 2004 American Cancer Society.
Correspondence estimation of the source profiles in receptor modeling
Authors: Gajewski Byron J. , Spiegelman Clifford H. 
Published: June 2004

AbstractThis article considers the estimation of source profiles from pollution data collected at one receptor site. At this receptor site, varying metrological conditions can cause errors that are possibly a mixture of distributions. A standard estimator utilizes a least squares approach because of its optimal properties under normally distributed errors and consistency under many other distributions. In contrast, we study the behavior of least squares relative to our new approach, which is better suited for dealing with errors having a mixture of distributions. The estimator loses efficiency under normal errors, but in turn gains efficiency while in the presence of a mixture of distributions. The new alternative has a tuning constant that determines the level of efficiency, which we show using asymptotic theory for large samples and simulation for small samples. An example from Houston, TX, U.S.A. is considered. Copyright © 2004 John Wiley & Sons, Ltd.