bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarities and differences in gene expression profiles of BRCA1 methylated and mutated epithelial ovarian cancers
Authors: Sahnane Nora , Libera Laura , Facchi Sofia , Carnevali Ileana , Ronchi Susanna , Albeni Chiara , Cromi Antonella , Casarin Jvan , Sessa Fausto , Tibiletti Maria Grazia 
Published: October 2023

IntroductionBRCA1 methylated (BRCA1met) epithelial ovarian cancer (EOC) is a recently defined and not well-investigated subset of neoplasms. To date, no studies have focused on the transcriptional profiles of BRCA1met cases, and, as a matter of fact, we still do not know if this subset of EOCs is similar, and to what extent, to BRCA1 mutated (BRCA1mut) cases.MethodsWe compared a group of 17 BRCA1met cases against 10 BRCA1mut cases using a subset of carefully selected 17 BRCAwt EOCs as a control group.ResultsFirst, BRCA1met cases showed a downregulation of the relative transcript, while this association was not observed for BRCA1mut EOCs. The BRCA1met group exhibited a general upregulation of homologous recombination (HR)-related genes, as well as BRCA1mut. Overall, BRCA1met had a different gene expression profile, characterized by diffuse downregulation, whereas BRCA1mut showed a general upregulation (p &lt; 0.0001). Both BRCA1-defective groups showed a slightly activated immune response mediated by interferon (IFN) gamma pathways.DiscussionIn conclusion, even if the expression profile of many genes related to DNA damage and repair system is shared between BRCA1mut and BRCA1met EOCs supporting that BRCA1met EOCs may benefit from PARPi therapies, our data demonstrate that BRCA1mut and BRCA1met EOCs show different expression profiles, suggesting a different mechanism of carcinogenesis that can be reflected in different responses to therapies and disease recovery.
Efficacy of traditional Chinese medicine on diabetic cardiomyopathy in animal models: a systematic review and meta-analysis
Authors: Hu Longxiao , Qian Longxin , Sun Aochuan , Cai Guida , Gao Yunxiao , Yuan Yue , Chen Xiaoxiao , Jiang Yunyao , Liu Jianxun , Ren Junguo 
Published: October 2023

Background: Diabetic cardiomyopathy (DCM) is a severe complication of diabetes that can diminish the quality of life in patients and is a leading cause of death. Research has demonstrated the effectiveness of Traditional Chinese Medicine (TCM) in reducing blood sugar levels and protecting cardiovascular function in both animal models and clinical research studies. Nevertheless, the efficacy of TCM in animal models of DCM has not been analyzed systematically.Method: We searched the following electronic bibliographic databases: Web of Science, PubMed, Cochrane Library, and CNKI(China National Knowledge Infrastructure). Studies that reported the efficacy of TCM in animals with DCM were included. The literature search was conducted using the terms. The data will be restricted from the year 2013 to 24 April 2023, 24 studies were included in the meta-analysis.Result: A total of 24 Traditional Chinese Medicine interventions and 2157 animals met the inclusion criteria. The pooled data revealed that TCM interventions resulted in significant improvements in body weight (BW), heart weight (HW) to body weight ratio (HW/BW), triglyceride (TG) and cholesterol (TC) levels, ejection fraction (EF), fractional shortening (FS) and E/A ratio. Subgroup analysis and meta-regression revealed that the type of TCM, duration of intervention, method of modeling, and animal species were potential sources of heterogeneity.Conclusion: TCM interventions were associated with significant improvements in body weight, heart weight to body weight ratio, triglyceride and cholesterol levels, left ventricular internal dimension in systole, ejection fraction, fractional shortening and E/A ratio. The heterogeneity in the results was found to be potentially due to the type of TCM, duration of intervention, method of modeling, and animal species, as shown in subgroup analysis and meta-regression.Systematic Review Registration: identifier CRD42023402908
Exposure-response analyses of efzofitimod in patients with pulmonary sarcoidosis
Authors: Walker Gennyne , Adams Ryan , Guy Lauren , Chandrasekaran Abhijeeth , Kinnersley Nelson , Ramesh Pavithra , Zhang Lu , Brown Fran , Niranjan Vis 
Published: October 2023

Background: Preliminary evidence for efficacy in pulmonary sarcoidosis has been shown for efzofitimod. Here we present supportive evidence of efficacy based on an exposure-response analysis.Methods: Data from two studies (Phase 1, N = 24, single dose in healthy volunteers, and Phase 1b/2a, N = 25, multiple doses over 24 weeks in participants with pulmonary sarcoidosis) were used to build a population pharmacokinetic model. Using this model, the relationship between efzofitimod exposure and three prespecified efficacy parameters [mean daily oral corticosteroid (OCS) dose, percent-predicted forced vital capacity (ppFVC) and King’s Sarcoidosis Questionnaire-Lung (KSQ-Lung) score] was explored. Linear regression described the relationship of efzofitimod exposure and OCS reduction, ppFVC and KSQ-Lung score. Logistic regression related efzofitimod exposure to the probability of achieving a minimal clinically important difference for ppFVC and KSQ-Lung score. Due to the small study size, trends (not statistical significance) in relationships are reported.Results: In patients with pulmonary sarcoidosis, as efzofitimod exposure increased, the mean daily OCS dose decreased, and ppFVC and KSQ-Lung score improved over baseline. The slope for all the endpoints by both linear and logistic regression showed an improving trend with increased exposure.Conclusion: These preliminary findings of a positive exposure-response across multiple efficacy endpoints support the claim that proof of concept has been established for the use of efzofitimod in pulmonary sarcoidosis.Clinical Trial Registration:clinicaltrials.gov, identifier NCT03824392
A study on the influencing factors and response strategies for young teachers from Taiwan to teach in universities in China: a push-pull-mooring model perspective
Authors: Wang Li , Miao Cong-Jin , Ye Jian-Hong , Huang Xin , Nong Liying , Nong Weiguaju 
Published: October 2023

IntroductionA growing number of Taiwanese teachers are choosing to teach at universities in mainland China, but their jobs are not always stable. Therefore, this study aims to investigate the factors infuencing young teachers from Taiwan to teach in universities in China.MethodsTwenty-seven young teachers from Taiwan with master’s or doctoral degrees who were willing to apply to work at universities in China and who were already teaching in China were invited to conduct in-depth interviews to collect research data.The interview data were coded and analyzed according to the Push-Pull-Mooring (PPM) Model.Results and discussionThe results showed that the understanding of mainland Chinese universities among young Taiwanese teachers is not entirely consistent. Taiwanese teachers who previously studied in mainland China have a more comprehensive understanding of mainland Chinese universities, and some teachers have gained a superfcial understanding through academic exchanges between the two sides and information shared by friends.However,still,7% of the teachers have no understanding at all. Most young Taiwanese teachers indicate that they do not understand the talent recruitment policies of mainland Chinese universities. The push factors that infuence young teachers from Taiwan to teach at mainland universities are: Oversupply of teachers in Taiwan, poor environment for higher education in Taiwan, poor articulation of the cross-strait academic system, and four aspects of teacher retirement and re-employment in Taiwan. The pull factors are: Benefcial policies, salary, living environment, educational advantages and cultural dissemination in 5 areas. Mooring factors are divided into 3 aspects: personal factors, environmental factors and social factors.
Predicting obsessive-compulsive disorder episodes in adolescents using a wearable biosensor—A wrist angel feasibility study
Authors: Lønfeldt Nicole Nadine , Olesen Kristoffer Vinther , Das Sneha , Mora-Jensen Anna-Rosa Cecilie , Pagsberg Anne Katrine , Clemmensen Line Katrine Harder 
Published: October 2023

IntroductionObsessive-compulsive disorders (OCD) are marked by distress, negative emotions, mental processes and behaviors that are reflected in physiological signals such as heart rate, electrodermal activity, and skin temperature. Continuous monitoring of physiological signals associated with OCD symptoms may make measures of OCD more objective and facilitate close monitoring of prodromal symptoms, treatment progress and risk of relapse. Thus, we explored the feasibility of capturing OCD events in the real world using an unobtrusive wrist worn biosensor and machine learning models.MethodsNine adolescents (ages 10–17 years) with mild to moderate-severe OCD were recruited from child and adolescent mental health services. Participants were asked to wear the biosensor in the lab during conditions of rest and exposure to OCD symptom-triggering stimuli and for up to 8 weeks in their everyday lives and register OCD events. We explored the relationships among physiological data, registered OCD events, age, OCD symptom severity and symptom types. In the machine learning models, we considered detection of OCD events as a binary classification problem. A nested cross-validation strategy with either random 10-folds, leave-one-subject-out, or leave-week(s)-out in both layers was used. We compared the performance of four models: logistic regression, random forest (RF), feedforward neural networks, and mixed-effect random forest (MERF). To explore the ability of the models to detect OCD events in new patients, we assessed the performance of participant-based generalized models. To explore the ability of models to detect OCD events in future, unseen data from the same patients, we compared the performance of temporal generalized models trained on multiple patients with personalized models trained on single patients.ResultsEight of the nine participants collected biosensor signals totaling 2, 405 h and registered 1, 639 OCD events. Better performance was obtained when generalizing across time compared to across patients. Generalized temporal models trained on multiple patients were found to perform better than personalized models trained on single patients. RF and MERF models outperformed the other models in terms of accuracy in all cross-validation strategies, reaching 70% accuracy in random and participant cross-validation.ConclusionOur pilot results suggest that it is possible to detect OCD episodes in the everyday lives of adolescents using physiological signals captured with a wearable biosensor. Large scale studies are needed to train and test models capable of detecting and predicting episodes.Clinical trial registrationClinicalTrials.gov: NCT05064527, registered October 1, 2021.
Gender differentials among small scale irrigation farmers’ income: empirical evidence from cabbage farmers in KwaZulu-Natal, South Africa
Authors: Mkuna Eliaza , Wale Edilegnaw 
Published: October 2023

IntroductionAgricultural productivity and income disparities prevail between male and female farmers in Sub-Saharan Africa. South Africa is not an exception to this ominous reality.MethodologyUsing data from smallholder irrigation farmers in KwaZulu-Natal, South Africa, this study analyzed the gender on-farm income gap by applying the Blinder-Oaxaca (OB) decomposition framework.ResultsThe findings indicate that there is a significant difference in farm income between male and female farmers. Male farmers earn significantly higher on-farm income than female farmers by about R26,788/cropping season.DiscussionThe findings suggest that existing and future programs should focus on institutional factors (land tenure) that affect access to resources and services. In addition to strategies to empower women, interventions to reduce the gender-induced farm income gap should focus on improving access to resources and services such as land with tenure security, agricultural input and output markets, training, information, and credit. Increasing the resource endowment and access to services by the female-managed farms is likely to significantly close the observed gender-induced farm income gap and improve the well-being of female farmers and their households.
EFEITO DO MIO-INOSITOL NA PRODUÇÃO IN VITRO DE EMBRIÕES OVINOS
Authors: AURELIANO ERIKA KAROLINE DE OLIVEIRA , LIMA ANDREZA MAYARA CARNEIRO , SANTOS DAMARIS RAQUEL PIRES , FREITAS BEATRIZ CAVALCANTI DE , SILVA JOSSIMARA DE MELO , KEALY PIMENTEL DE OLIVEIRA LUANA , LIMA SUELI DE OLIVEIRA , PEREIRA AILTON BATISTA , LOPES ISABELA MARIA , SILVA BRUNA MOURA , CORDEIRO MABEL FREITAS , LOPES JÚNIOR EDILSON SOARES 
Published: October 2023

O objetivo do trabalho foi avaliar o efeito da inclusão de mio-inositol no meio de maturação in vitro de oócitos sobre a PIV de embriões ovinos. A colheita de oócitos foi realizada a partir de ovários obtidos em abatedouro, os quais foram aspirados e levados à maturação in vitro, sendo divididos em quatro grupos: no grupo CON, os complexos cumulus oócitos (CCO) foram imersos em TCM-199, suplementado com 500 UI/mL de penicilina, 0,5 mg de estreptomicina, 1,25 µg de anfotericina, 0,2 mM de piruvato de sódio, 10% (v/v) de soro fetal bovino (SFB), 10 ng/mL de fator de crescimento epidérmico (EGF), 10 µg/mL de FSH e LH e µg/ml 17β-estradiol; nos grupos MIO20, MIO30 e MIO40, os oócitos foram maturados no meio do grupo CON, suplementado com 20, 30 e 40 mM de mio-inositol. Após isso, os oócitos foram avaliados quanto a presença ou ausência da expansão de células do cumulus e quanto ao grau de expansão e destinados à fecundação in vitro, em meio FIV, juntamente com espermatozoides. Após a FIV, foram avaliados os presumíveis zigotos que seguiram para o cultivo in vitro. Foram avaliadas clivagens no dia 1 e dia 2, sendo dia 0 o dia do início do cultivo in vitro. Os dados foram apresentados em porcentagem e foi utilizado o teste do Qui-quadrado no software Epi Info. Os resultados foram considerados significativos quando P<0,05. Foi notório que não houve diferença significativa em relação aos oócitos com expansão ou sem expansão das células do cumulus nos grupos MIO20, MIO30 e MIO40. Em relação ao grau de expansão das células do cumulus, número de presumíveis zigotos e ao número de estruturas clivadas, o mio-inositol não mostrou diferença significativa em relação ao grupo CON. Com base nessas informações, conclui-se que o mio-inositol mostrou eficaz ação antioxidante, atuando de maneira relevante na maturação oocitária. Contudo, são necessários mais estudos para esclarecer os efeitos do mio-inositol na FIV ovina.
Un metodo di Embodied Education in Riabilitazione: approcci di valutazione partecipata e di empowerment psicocorporeo
Authors: Diamare Sara , Ferrara Anna , Polito Gaetana , Salerno Marina , Mantice Marinella , Pocetta Giancarlo 
Published: October 2023

Nella teoria bio-psico-sociale, la visione salutogenetica (Antonowsky, 1979) è volta a promuovere il benessere. La promozione della salute indica un processo di cambiamento e sviluppo adattivo diretto alla prevenzione primaria, secondaria e terziaria attraverso la diffusione di stili di vita sani. Nel presente lavoro si propone un modello di salutogenesi: “I Salotti del Ben-Essere” (S. Diamare, 2015), sperimentato dall’ASL NA 1 Centro UOC. Qualità e Umanizzazione, che prevede lo sviluppo di tematiche di salutogenesi in laboratori esperienziali di consapevolezza psico- corporea, implementato in Campania attraverso la rete OMS di Promozione della Salute: Health Promoting Hospitals & Health Service (HPH & HS). Quale approccio olistico di Health Advocacy, I Salotti del Ben-Essere© rappresentano uno spazio multicentrico e multiprofessionale di assistenza partecipativa, rivolta a piccoli gruppi ed a comunità, in cui un team specializzato realizza un programma multidisciplinare di educazione sanitaria prevalentemente in un setting di riabilitazione. L’educazione alla salute trova, durante un trattamento riabilitativo, la collocazione più proficua per sostenere la motivazione al cambiamento consapevole di stili di vita perniciosi. Il metodo “Salotti del Ben-Essere” può essere utilizzato, come Peer Education, anche nel sistema universitario. Questa metodologia è stata testata, infatti, con gli studenti di Scienze dell’Educazione presso l’Università Suor Orsola Benincasa. I risultati sono stati soddisfacenti in tutti i contesti.
In bio-psycho-social theory, the salutogenetic view (Antonowsky, 1979) is aimed at promoting well-being. Health promotion indicates a process of change and adaptive development aimed at primary, secondary and tertiary prevention through the diffusion of healthy lifestyles. This work proposes a model of salutogenesis: "I Salotti del Ben-Essere" (S. Diamare, 2015), tested by the ASL NA 1 Centro UOC. Quality and Humanization, which involves the development of Salutogenesis themes in experiential psycho-body awareness workshops, implemented in Campania through the WHO Health Promotion network: Health Promoting Hospitals & Health Service (HPH & HS). As a holistic approach to Health Advocacy, I Salotti del Ben-Essere© represent a multi-centre and multi-professional space of participatory assistance, aimed at small groups and communities, in which a specialized team carries out a multidisciplinary health education program mainly in a rehabilitation setting . Health education finds, during a rehabilitation treatment, the most profitable place to support the motivation to consciously change pernicious lifestyles. The "Salotti del Ben-Essere" method can also be used, like Peer Education, in the university system. In fact, this methodology was tested with students of Educational Sciences at the Suor Orsola Benincasa University. The results were satisfactory in all contexts.
Ultrasonography in physiotherapy and rehabilitation
Authors: Barassi Giovanni , Guerri Sergio , Tavani Roberta , Ricucci Giampiero , De Luca Giorgia , Rabini Alessia , Colombo Antonio , Di Iorio Angelo 
Published: October 2023

There is an interrelation with ultrasound / physiotherapist and the duty of the physiotherapist to know how to perform ultrasound examinations alone, not for diagnostic purposes, to follow the evolution of the therapeutic cycle of physiotherapy. For this reason, ultrasound image analysis (US) is a promising non-invasive approach that uses load-dependent changes in the intensity of the echo to characterize the rigidity of muscle and tendon tissue. The purpose of this contribution is to improve the use of ultrasound images (US) and the role of the physiotherapist, who are able to detect localized changes, in particular in stiffness of the tendon due to partial and full-thickness tendon tears. Image intensity information is less sensitive for identifying load transmission variations resulting from partial thickness cuts initiated on the joint side. Ultrasound images can be useful for quantitatively assessing the variations dependent on the tendon load and muscle stiffness in physiotherapy and that the interruption of the behavior of the acousto-elastic ultrasound images can be indicative of substantial damage to the muscle or tendon.
Models and organizational pathways in the treatment of acute stroke
Authors: Romano Daniele , Grimaldi Grazia , Grimaldi Antonio 
Published: October 2023

Stroke due to its sudden and nefarious course is today considered “a medical emergency” that requires proper prevention and adequate and time-depending treatment. To follow the adequate guidelines (AHA-ASA 2018 and ESO-ISO 2018), stroke treatment involves the use of intravenous thrombolysis (IV) with Alteplase (or recombinant tissue plasminogen activator - r-tPA) within the first 4.5 hours of symptom onset and endovascular treatment within the first 6 hours if there were obstruction of large vessels such as the intracranial internal carotid artery, the middle cerebral artery (M1-M2), the anterior cerebral artery (A1) , the basilar artery and the tract intracranial vertebral artery. After the described options of treatment the hospitalization in the “Stroke Units” is fundamental. This aspect, in the past largely undervalued, plays today a pivotal role in the patient’s “care”: continuous monitoring, combined with careful clinical observation, are, in fact, essential in order to both facilitate a faster possible rehabilitation of the patient , both to prevent any complications and / or exacerbation of the disease (or the possible closure of the vessel). Aim of our lecture is to describe the result of years of controlled clinical trials, which have allowed us to reach a good level of knowledge on the efficacy and safety of the various therapeutic aids, only mentioned above, and whose use is regulated in detail by the main Guidelines (LG) in force today, including the Italian ISO-SPREAD LGs of 2016 [1] and the LGs produced by the American Heart Association (AHA), of which the American Stroke Association (ASA) represents a sector, and whose latest update is from 2018 [2].
Vibrations and spasticity
Authors: Supplizi Marco , Barassi Giovanni , Visciano Christian Pasquale , Zincani Valentina , Di Iulio Antonella , Marangi Matteo , Marrone Andrea Maria , Di Iorio Angelo 
Published: October 2023

This experimental study aims to evaluate and validate the effectiveness of the proposed application method in the use of “focused mechanical vibrations” for the treatment of muscle spasticity. The basic concept of this study is that in spasticity, by specifically stimulating some clearly identifiable trigger points of the body, better results are obtained; in fact, with the localized mechanical-sound vibrations, by positioning the handpiece for the treatment on those specific points, immediate generalized relaxation of the entire spastic muscle is obtained through reflex pathways. To evaluate this operative reality we treated 5 subjects affected by neurological pathology with spasticity and at T0 time (before treatment) and at T1 time (immediately after treatment), they were assessed with Ashworth Scale, Passive joint evaluation, Evaluation of active motility, Test of Bahkta (for non-functioning hand), surface electromyography The subjects were treated with a 120Hz vibratory therapy handpiece for a total time of 15 minutes The data showed us a clear improvement of the parameters lost in the exam, in the less serious patients and a good improvement also in the most serious subjects.