bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insight into circRNAs: characterization, strategies, and biomedical applications
Authors: Feng Xin-Yi , Zhu Shun-Xin , Pu Ke-Jia , Huang Heng-Jing , Chen Yue-Qin , Wang Wen-Tao 
Published: October 2023

AbstractCircular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing. Advanced high-throughput RNA sequencing and experimental technologies have enabled the extensive identification and characterization of circRNAs, such as novel types of biogenesis, tissue-specific and cell-specific expression patterns, epigenetic regulation, translation potential, localization and metabolism. Increasing evidence has revealed that circRNAs participate in diverse cellular processes, and their dysregulation is involved in the pathogenesis of various diseases, particularly cancer. In this review, we systematically discuss the characterization of circRNAs, databases, challenges for circRNA discovery, new insight into strategies used in circRNA studies and biomedical applications. Although recent studies have advanced the understanding of circRNAs, advanced knowledge and approaches for circRNA annotation, functional characterization and biomedical applications are continuously needed to provide new insights into circRNAs. The emergence of circRNA-based protein translation strategy will be a promising direction in the field of biomedicine.
Psychometric analysis of the revised CompLEC test to measure reading speed and reading comprehension in university students
Authors: Alburqueque Claudia Milagros Arispe , Rivera-Lozada Oriana , Vicente Judith Soledad Yangali , Tomás Melba Rita Vásquez , Vilca Lindsey W. , Soto Ramiro Alcides Enciso , Huari María Ysabel Alvarez 
Published: October 2023

Abstract
Background
At university level, reading comprehension is one of the most important linguistic competences in the professional training of students because it is an instrument that enables the acquisition and production of scientific knowledge. Likewise, at this level of education, speed reading becomes a technique that allows to make the most of the time devoted to reading and to develop the ability to concentrate. However, there are not many instruments in the scientific literature that measure these two variables; therefore, the objective of this study was: To determine the psychometric properties of the revised compLEC test to measure reading comprehension and speed in university students.

Method
The study was conducted under the quantitative approach, applied type, with non-experimental design. The type of sampling used was non-probabilistic and the sample consisted of 441 university students of both genders. The instrument prepared and applied was the Reading Speed and Reading Comprehension Test for Higher Education, which is an adaptation of the CompLEC test.

Results
In the study, all the items had values above 0.80, which shows that the items were rated positively in terms of pertinence, relevance, and clarity. It was also evidenced that the model of three related factors presents adequate fit indices (CFI = 0.91; TLI = 0.90; RMSEA = 0.034 [IC90% 0.021 ‒ 0.046]; SRMR = 0.072). On the other hand, only the Recovery dimension (ordinal α = 0.62) presented acceptable reliability indices.

Conclusion
The results show that the Reading Speed and Reading Comprehension Test for Higher Education has adequate psychometric characteristics in terms of content validity and internal structure of the scale. However, further studies are required to confirm the reliability of the scale.
COVID-19 stress and coping strategies among older adults: a systematic review of qualitative evidences
Authors: Ahmadi Amir , Allahverdipour Hamid , Valiee Sina , Pashazadeh Fariba , Ghassab-Abdollahi Nafiseh , Abdoli Faranak , Matlabi Hossein 
Published: October 2023

Abstract
Background
The COVID-19 pandemic has brought about far more stressful conditions for people worldwide. As a vulnerable group, older adults have suffered various psychological problems, such as stress, because of this pandemic and have applied various strategies to cope with the dire consequences. This study aimed to synthesize qualitative evidence regarding coping strategies for stressful situations among older adults throughout the COVID-19 pandemic.

Methods
We searched electronic databases, including Scopus, Embase, PubMed, ProQuest, and the Cochrane Library, based on PRISMA standards. The protocol of this systematic review was registered on the PROSPERO (registration code: CRD42022364831). All relevant English-language articles published between 2019 and November 10, 2022, were searched. We reviewed the reference lists for all the included studies and key references. Two reviewers conducted screening, data extraction, and quality appraisal independently, with disagreements resolved by consensus with all team members. The Joanna Briggs Institute (JBI) checklist was used to assess the quality of studies. A thematic synthesis of the selected studies was conducted.

Results
We included 13 studies in our review. Most studies were conducted in the early months of the COVID-19 pandemic. The stress caused by the COVID-19 pandemic was classified into six categories: health management challenges, stress caused by quarantine, economic challenges, media and bad news stress, virus threats, and challenges related to the use of communication technologies. The strategies used by older adults to cope with these challenges were categorized into five categories: protective strategies, avoidance strategies, maintaining social connections, meaning-based strategies, and fun strategies. This research showed that depending on the situation and conditions, older adults use various strategies to cope with COVID-19.

Conclusion
Older adults experience much stress during the COVID-19 pandemic. In most cases, older adults can cope with these challenges with simple strategies from previous experiences and learnings. Older people require educational interventions in some cases, such as those involving communication skills. A better understanding of older adults coping strategies may enable policymakers to develop more effective policies and manage the problems of older adults in post-COVID situations.
Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity
Authors: Wu Bowen , Li Peng , Qiu Eryue , Chen Jian 
Published: October 2023

AbstractChemotherapy resistance hinders the successful treatment of osteosarcoma (OS) to some extent. Previous studies have confirmed that metformin (Met) enhances apoptosis induced by chemotherapeutic drugs, but the underlying mechanism remains unclear. To establish adriamycin (ADM)-resistant MG-63 (MG-63/ADM) cells, the dosage of ADM was progressively increased. The results of qRT-PCR and Western blotting demonstrated that the expression level of Yin Yang 1 (YY1) and multi-drug resistance-1 (MDR1) in MG-63/ADM cells were remarkably increased compared with those in MG-63 cells. Met dramatically enhanced ADM cytotoxicity and accelerated apoptosis of MG-63/ADM cells. Moreover, Met suppressed the expressions of YY1 and MDR1 in MG-63/ADM cells. YY1 promoted its transcriptional expression by directly binding to the MDR1 promoter. Furthermore, the effects of Met on ADM sensitivity in MG-63/ADM cells was reversed due to overexpression of YY1 or MDR1. Collectively, these findings suggested that Met inhibited YY1/MDR1 pathway to reverse ADM resistance in OS, providing a new insight into the mechanism of Met in ADM resistance of OS.
Self-management of patients with tracheostomy in the home setting: a scoping review
Authors: Weidlich Sandra , Pfeiffer Jens , Kugler Christiane 
Published: October 2023

Abstract
Purpose
The aim of this study was to create a model of patient-centered outcomes with respect to self-management tasks and skills of patients with a tracheostomy in their home setting.

Methods
A scoping review using four search engines was undertaken (Medline, CINAHL, PsycINFO, Cochrane Library) to identify studies relevant to this issue and published since 2000. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statements for Scoping Reviews (PRISMA-ScR), the Joanna Briggs Institute (JBI) approach of conducting and reporting a scoping review, and the Participants, Concept, Context (PCC) scheme were employed. The following elements of the framework synthesis study data were screened, and presented based on the self-management model of Lorig and Holman.

Results
34 publications from 17 countries met the criteria for study inclusion: 24 quantitative, 8 qualitative and 2 mixed methods designs. Regarding the dimensions of self-management, 28 articles reported on “managing the therapeutic regimen”, 27 articles discussed “managing role and behavior changes”, and 16 articles explored “managing emotions”. A model of self-management of patients with tracheostomy was developed, which placed the patient in the center, since it is this individual who is completing the tasks and carrying out his or her skill sets.

Conclusion
This scoping review represents the first comprehensive overview and modeling of the complex self-management tasks and skills required of patients with tracheostomy in their home setting. The theoretical model can serve as a cornerstone for empirical intervention studies to better support this patient-centered outcome for this population in the future.
Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults
Authors: Waziry R. , Gu Y. , Williams O. , Hägg S. 
Published: October 2023

Abstract
Background
Saliva measures are generally more accessible than blood, especially in vulnerable populations. However, connections between aging biology biomarkers in different body tissues remain unknown.

Methods
The present study included individuals (N = 2406) who consented for saliva and blood draw in the Health and Retirement Telomere length study in 2008 and the Venous blood study in 2016 who had complete data for both tissues. We assessed biological aging based on telomere length in saliva and DNA methylation and physiology measures in blood. DNA methylation clocks combine information from CpGs to produce the aging measures representative of epigenetic aging in humans. We analyzed DNA methylation clocks proposed by Horvath (353 CpG sites), Hannum (71 CpG sites), Levine or PhenoAge, (513 CpG sites), GrimAge, (epigenetic surrogate markers for select plasma proteins), Horvath skin and blood (391 CpG sites), Lin (99 CpG sites), Weidner (3 CpG sites), and VidalBralo (8 CpG sites). Physiology measures (referred to as phenotypic age) included albumin, creatinine, glucose, [log] C-reactive protein, lymphocyte percent, mean cell volume, red blood cell distribution width, alkaline phosphatase, and white blood cell count. The phenotypic age algorithm is based on parametrization of Gompertz proportional hazard models. Average telomere length was assayed using quantitative PCR (qPCR) by comparing the telomere sequence copy number in each patient’s sample (T) to a single-copy gene copy number (S). The resulting T/S ratio was proportional to telomere length, mean. Within individual, relationships between aging biology measures in blood and saliva and variations according to sex were assessed.

Results
Saliva-based telomere length showed inverse associations with both physiology-based and DNA methylation-based aging biology biomarkers in blood. Longer saliva-based telomere length was associated with 1 to 4 years slower biological aging based on blood-based biomarkers with the highest magnitude being Weidner (β =  − 3.97, P = 0.005), GrimAge (β =  − 3.33, P < 0.001), and Lin (β =  − 3.45, P = 0.008) biomarkers of DNA methylation.

Conclusions
There are strong connections between aging biology biomarkers in saliva and blood in older adults. Changes in telomere length vary with changes in DNA methylation and physiology biomarkers of aging biology. We observed variations in the relationship between each body system represented by physiology biomarkers and biological aging, particularly at the DNA methylation level. These observations provide novel opportunities for integration of both blood-based and saliva-based biomarkers in clinical care of vulnerable and clinically difficult to reach populations where either or both tissues would be accessible for clinical monitoring purposes.
Prevalence of frailty in severe mental illness: findings from the UK Biobank
Authors: Warren Nicola , Leske Stuart , Arnautovska Urska , Northwood Korinne , Kisely Steve , Siskind Dan 
Published: October 2023

Background
Severe mental illness (SMI) is associated with significant morbidity. Frailty combines biological ageing, comorbidity and psychosocial factors and can predict adverse health outcomes. Emerging evidence indicates that frailty is higher in individuals with SMI than in the general population, although studies have been limited by sample size.

Aims
To describe the prevalence of frailty in people with SMI in a large cohort using three different frailty measures and examine the impact of demographic and sociodemographic variables.

Method
The UK Biobank survey data, which included individuals aged 37–73 years from England, Scotland and Wales from 2006 to 2010, with linked in-patient hospital episodes, were utilised. The prevalence of frailty in individuals with and without SMI was assessed through three frailty measures: frailty index, physical frailty phenotype (PFP) and Hospital Frailty Risk Score (HFRS). Stratified analysis and dichotomous logistic regression were conducted.

Results
A frailty index could be calculated for 99.5% of the 502 412 UK Biobank participants and demonstrated greater prevalence of frailty in women and an increase with age. The prevalence of frailty for those with SMI was 3.19% (95% CI 3.0–3.4), 4.2% (95% CI 3.8–4.7) and 18% (95% CI 15–23) using the frailty index, PFP and HFRS respectively. The prevalence ratio was between 3 and 18 times higher than in those without SMI.

Conclusions
As a measure, frailty captures the known increase in morbidity associated with SMI and may potentially allow for earlier identification of those who will benefit from targeted interventions.
ECONOMIC SECURITY OF THE REGIONS OF THE RUSSIAN FEDERATION THROUGH THE PRISM OF THE FORMATION OF TERRITORIES OF SUSTAINABLE INNOVATIVE DEVELOPMENT
Authors: Belyaev Vladislav V. , Besedin Alexander L. , Egorushkina Tatyana N. 
Published: October 2023

The current period of economic formation is characterized by the active development of global processes and global crises, which are accompanied by the strengthening and aggravation of relations between countries, the aggravation of political and economic problems, which ultimately entails a loss of stability and the potential for their development. In this connection, the most important problem is ensuring the economic security of the country, which is necessary not only for its independence and the protection of its economy from external and internal threats, but also will ensure the economic sovereignty of the country and the unity of its economic space. It is impossible to imagine the economic security of a country without an innovative component that combines various types of resources: technical, technological, managerial, infrastructural and other resources and factors affecting the implementation of innovative processes that are the basis of modern socio-economic development of countries and regions.
Preparation and implementation of projects to create a new formation of sustainable innovative development of the territory, taking into account the specific features of the development of cities and their regions during the period of deep transformational changes in the world economy is a priority task
The analysis makes it possible to conclude that it is necessary to develop a systematic approach to the formation of territories of sustainable innovative development, taking into account the assessment of the relationship between improving the efficiency of socio-economic development of the region with a stabilizing effect and the initialization of an innovative breakthrough in the activities of enterprises and organizations in the global global crisis.
Purpose. Development of a systematic approach to the formation of territories of sustainable innovative development in the context of the global crisis in order to ensure the economic security of the region.
Methodology in article: methods as classification, generalization, typology, analysis and synthesis, comparison and comparison, method of logical interpretation, method of analogy, method of proof, method of logical justification.
Results: Specific methods and tools for creating territories of innovative development of a new formation are formulated within the framework of economic transformations carried out in the country under the conditions of sanctions pressure in order to increase the level of national economic security.
Practical implications it is advisable to apply the results obtained to improve the quality of management in the formation of an innovative strategy for the economic security of the subjects of the Russian Federation
Temperature and Humidity Control System for 20 kV of Cubicle with Multiple Input Multiple Output Fuzzy Logic Controller
Authors: Ramadhan Mochammad Berliano Putra , Efendi Moh. Zaenal , Nugraha Syechu Dwitya 
Published: October 2023

Cubicle 20 kV is a crucial electrical equipment in the 20 kV power distribution system. Often, cubicle issues arise due to excessively low or high temperatures and humidity, which can lead to the presence of water spots and corrosion on the components inside the 20 kV cubicle. One of the efforts to maintain the reliability of this 20 kV cubicle is to ensure that the temperature and humidity inside the cubicle remain within their operational limits. To achieve this, a system is needed to control the temperature and humidity in the 20 kV cubicle. The system can monitor and control the temperature and humidity inside the cubicle by adjusting the activation angle of the exhaust fan and heater. Control is achieved using a multiple-input, multiple-output fuzzy logic controller. The main components of this system are the STM32 microcontroller, DHT22 sensor, and ESP8266 module for monitoring temperature and humidity via a website. System has successfully controlled temperature and humidity d with a set point value of 35 °C and humidity of 60% RH. This implementation of fuzzy multiple input multiple outputs has performed well and resulted in only a small error of 0.55% for temperature and 1.05% for humidity.With the presence of this device, the temperature and humidity in the cubicle 20 kV can be controlled, and it enables the PLN operator to easily monitor and maintain the cubicle 20 kV.
Fusion of an Impacted Third and Supernumerary Fourth Molar Tooth with Concrescence of the Second Molar
Authors: Leow Julian , Solanki Kohmal , Kumar Mahesh 
Published: October 2023

We report the case of a symptomatic 41-year-old female presenting with fusion of an impacted third (LL8) and fourth (LL9) mandibular molar tooth with concrescence of the second molar tooth (LL7). Cone-beam computed tomography showed direct contact with the inferior dental nerve (IDN) and lingual aspect of the double tooth. The patient underwent surgical removal of the LL8–LL9 using piezoelectric surgery. We present the first case of successfully using pre-operative CBCT in the planning of surgery and piezoelectric surgery to separate an impacted fused LL8–LL9 from a concrescent LL7 without causing trauma to the LL7 or intimately positioned IDN.CPD/Clinical Relevance: An impacted fused mandibular third and supernumerary fourth molar with concrescence of the second molar requires very careful management.
Psychological status affects postoperative quality of life, function, and pain after periacetabular osteotomy
Authors: Wagener Nele , Löchel Jannis , Hipfl Christian , Perka Carsten , Hardt Sebastian , Leopold Vincent J. 
Published: October 2023

AimsPsychological status may be an important predictor of outcome after periacetabular osteotomy (PAO). The aim of this study was to investigate the influence of psychological distress on postoperative health-related quality of life, joint function, self-assessed pain, and sports ability in patients undergoing PAO.MethodsIn all, 202 consecutive patients who underwent PAO for developmental dysplasia of the hip (DDH) at our institution from 2015 to 2017 were included and followed up at 63 months (SD 10) postoperatively. Of these, 101 with complete data sets entered final analysis. Patients were assessed by questionnaire. Psychological status was measured by Brief Symptom Inventory (BSI-18), health-related quality of life was raised with 36-Item Short Form Survey (SF-36), hip functionality was measured by the short version 0f the International Hip Outcome Tool (iHOT-12), Subjective Hip Value (SHV), and Hip Disability and Outcome Score (HOS). Surgery satisfaction and pain were assessed. Dependent variables (endpoints) were postoperative quality of life (SF-36, HOS quality of life (QoL)), joint function (iHOT-12, SHV, HOS), patient satisfaction, and pain. Psychological distress was assessed by the Global Severity Index (GSI), somatization (BSI Soma), depression (BSI Depr), and anxiety (BSI Anx). Influence of psychological status was assessed by means of univariate and multiple multivariate regression analysis.ResultsIn multiple multivariate regression, postoperative GSI, BSI Soma, and BSI Depr had a negative effect on postoperative SF-36 (e -2.07, -3.05, and -2.67, respectively; p < 0.001), iHOT-12 (e -1.35 and -4.65, respectively; p < 0.001), SHV (e -1.20 and -2.71, respectively; p < 0.001), HOS QoL (e -2.09 and -4.79, respectively; p < 0.001), HOS Function (e -1.00 and -3.94, respectively; p < 0.001), and HOS Sport (e -1.44 and -5.29, respectively; p < 0.001), and had an effect on postoperative pain (e 0.13 and 0.37, respectively; p < 0.001).ConclusionPsychological distress, depression, and somatization disorders affect health-related quality of life, perceived joint function, and sports ability. Pain perception is significantly increased by somatization. However, patient satisfaction with surgery is not affected.Cite this article: Bone Jt Open 2023;4(10):758–765.