bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rome vue de l’Empire portugais: Manuel Godinho de Erédia (1558?-1623) et sa Summa de Arvores e Plantas da Índia intra Gangez
Authors: Couto Dejanirah 
Published: November 2023

A partir del itinerario y la obra de una figura original de la sociedad imperial portuguesa, Manuel Godinho de Erédia (1558?-1623), el artículo reflexiona sobre las complejas relaciones entre dos capitales, entre dos Romas de la segunda mitad del siglo XVI: aquella presente en los mapamundi de nuestras historiografías ordinarias, del imperio espiritual de la catolicidad postridentina fundado sobre las ruinas del gran imperio antiguo; y la menos familiar, la segunda capital de un imperio portugués en vías de expansión hacia el Este y finalmente extendido a escala mundial. Destaca el doble sistema de referencias que nutre y pretende fortalecer el crédito erudito de Erédia, hombre de la Roma de Oriente, terreno humanista de una cultura compartida con sus contemporáneos más allá de las distancias: el horizonte renovado, portado por la corona ibérica, de una construcción imperial que no iguala sino que supera a la de la antigua Roma. La lectura que se propone de las numerosas producciones de Erédia, en particular de su Atlas o de su Summa de Arvores e Plantas da Índia intra Gangez, pretende arrojar luz sobre este doble sistema de referencias que teje así otra visión de la producción de conocimiento, con, contra o desde Roma, a finales del siglo XVI.
La Medicina Interna en la Gestión de Enfermedades Crónicas: Enfoque Clínico, Desafíos y Direcciones Futuras
Authors: Urzola Suárez María Rosa , Ayala Trujillo Héctor Daniel , Sanmartin Jaramillo Pamela Alejandra , Moreira Gómez Kiara Madelaine , Robles Barahona Nahin Isaac , Icaza Latorre David Antonio , Armijos Caicedo Tatiana Nancy 
Published: November 2023

Introducción: Este artículo revisa el papel de la Medicina Interna en la gestión de enfermedades crónicas, enfocándose en el enfoque clínico actual, los desafíos y las direcciones futuras. Las enfermedades crónicas plantean una carga significativa, y la Medicina Interna, con su enfoque holístico, es crucial en su manejo.
Desarrollo: Se identificaron estrategias integrales y personalizadas para el tratamiento, la importancia de la prevención y la detección temprana, y la gestión de la polifarmacia. Los desafíos incluyen la coordinación de la atención, la integración de tecnologías emergentes y las disparidades en el acceso a la atención.
Aplicaciones prácticas o futuras líneas de investigación: Se sugiere la personalización del tratamiento, la integración de herramientas tecnológicas y programas de educación para pacientes. Las futuras investigaciones deben enfocarse en la efectividad de las estrategias de gestión integrada, el impacto de las tecnologías emergentes y el desarrollo de nuevos modelos de cuidado.
Conclusiones: La Medicina Interna tiene un papel fundamental en la gestión de enfermedades crónicas, enfrentando desafíos que requieren enfoques innovadores y colaborativos. Las direcciones futuras y las investigaciones deben centrarse en mejorar continuamente la atención y los resultados para los pacientes.
ANALISIS PENOLAKAN PENDIRIAN PT JAKA MITRA MENURUT PERATURAN DAERAH LAMONGAN (PERDA) NOMOR 01 TAHUN 2014 TENTANG IZIN LINGKUNGAN
Authors: Moch. Haidar Ali Al-Hamid  
Published: November 2023

The purpose of this research is to find out the community's rejection of the Paciran Lamongan Kemantren Village community for the development of PT Jaka Mitra which is constrained by the AMDAL problem which is seen from the normative point of view of the Lamongan Regency Regional Regulation Number 1 of 2014 concerning Environmental Permits. The research method used in this research is normative research, emphasizing the function of AMDAL as an instrument to prevent pollution and environmental damage. in normative research, the processing of legal materials is systematized by law. Legal materials are then analyzed qualitatively, analyzing with systematic thinking to provide answers to problems. The results of this study are that AMDAL as one of the requirements in environmental permits is a study of activities that are systematically and scientifically regulated using an interdisciplinary and even multidisciplinary approach, therefore AMDAL research must be structured in a coherent and comprehensive-integral manner. When this is not resolved, the development of industrial estates cannot be carried out, this is as an example of the case that happened to PT Jaka Mitra which resulted in the revocation of permits and termination of the project due to EIA problems.
Keywords: Research, Regulation, Analyzing, interdisciplinary, development
Interoperability standards in Health Information Systems
Authors: Canova-Barrios Carlos , Machuca-Contreras Felipe 
Published: November 2023

Introduction: Health Information Systems (HIS) have been improved to enhance the quality of healthcare. However, adequate computerization of these systems, as demanded by the digital society, requires the adoption of interoperability standards that allow all system elements to be interconnected. Objective: to describe the results provided by the literature on the use of interoperability standards in HIS. Methods: a systematic review was conducted using the PRISMA methodology on the results of the adoption of interoperability standards in HIS. Information was searched in Scopus, Medline, Google Scholar, and SciELO. Then, a selection of the most relevant studies was made, using inclusion criteria. Results: most of the reviewed studies focused on the evaluation of interoperability standards in hospital and institutional environments, with a global interest in such standards. The diversity of standards used and the results obtained demonstrate the importance and significant impact of the implementation of interoperability standards in improving the quality of healthcare systems. Conclusions: the systematic literature review reveals that the implementation of interoperability standards is fundamental to ensure the integration between the components that make up the systems, which in turn contributes to operational efficiency and information security
NGHIÊN CỨU BÀO CHẾ BỘT PHYTOSOME SILYBIN BẰNG PHƯƠNG PHÁP PHUN SẤY
Authors: Vũ Bình Dương , Đặng Trường Giang , Hồ Bá Ngọc Minh , Nguyễn Hoàng Hiệp , Phạm Văn Hiển 
Published: November 2023

Mục tiêu: Xây dựng quy trình phun sấy tạo bột phytosome silybin từ hỗn dịch nano phytosome. Phương pháp nghiên cứu: Phun sấy tạo bột cao khô bằng thiết bị phun sấy ly tâm LPG-5 từ hỗn dịch nano phytosome silybin. Đánh giá ảnh hưởng của các yếu tố đến quá trình phun sấy gồm: Loại tá dược (maltodextrin, Aerosil), tỷ lệ tá dược/chất rắn (TD/CR), nhiệt độ phun sấy và tốc độ cấp dịch. Kết quả: Lựa chọn được thông số quy trình phun sấy thích hợp: Tá dược hỗ trợ phun sấy: MD/AE (80/20); tỷ lệ tá dược/chất rắn: 0,5/1; nhiệt độ khí đầu vào: 140ºC; tốc độ cấp dịch: 10 mL/phút. Bột phytosome silybin phun sấy (công thức M7) có độ ẩm là 3,46 ± 0,1%, khối lượng riêng 0,416 ± 0,02 g/mL, chỉ số nén 19,33 ± 0,83% hàm lượng silybin toàn phần là 13,97 ± 0,46%, hàm lượng silybin dạng phytosome là 12,82 ± 0,27%. Kết luận: Xây dựng thành công quy trình tạo bột phytosome silybin bằng phương pháp phun sấy để ứng dụng vào các dạng thuốc rắn dùng đường uống.
NGHIÊN CỨU XÂY DỰNG MÔ HÌNH XƠ GAN VÀ ĐÁNH GIÁ TÁC DỤNG CỦA VIÊN NANG NHẤT GAN LINH TRÊN ĐỘNG VẬT THỰC NGHIỆM
Authors: Đinh Quốc Hưng , Bùi Thị Thu Hà , Nguyễn Thị Thanh Hằng , Bùi Thị Thu Hiền , Trần Thị Thu Huyền , Trần Bá Hiếu , Đoàn Việt Cường , Phạm Xuân Phong , Trần Thị Tuyết Nhung , Chử Văn Mến 
Published: November 2023

Mục tiêu: Xây dựng mô hình xơ gan trên chuột BALB/c bằng CCl4 với thời gian, liều lượng tối ưu của CCl4, và đánh giá tác dụng điều trị xơ gan của viên nang Nhất gan linh (NGL). Phương pháp nghiên cứu: Gây xơ gan trên chuột nhắt trắng BALB/c được tiêm dưới da CCl4 với liều 160 mg/kg pha trong dầu olive với tỷ lệ 1:18 tương ứng với liều 2 mL/kg x 2 lần/tuần trong thời gian 4, 8 và 12 tuần. Chuột sau khi được gây xơ gan, cho uống NGL với các mức liều từ 150 - 450 mg/kg/ngày. Đánh giá hiệu quả điều trị xơ gan dựa trên các chỉ tiêu thay đổi trọng lượng, số lượng sống/chết, chỉ số xét nghiệm huyết học, sinh hóa máu, phân tích mô bệnh học. Kết quả: Mô hình xơ gan trên chuột nhắt bằng CCl4 đã cho thấy mức độ xơ hóa gan ở giai đoạn 1/4; 2/4; 2/4 và 3/4 tương ứng với thời gian sử dụng CCl4 từ 4, 8, và 12 tuần. Chuột được điều trị bằng NGL liều tương đương lâm sàng, gấp đôi và gấp ba liều lâm sàng đều có khả năng cải thiện tổn thương gan ở mức sinh hóa, tế bào. Kết luận: NGL chứng minh được tác dụng điều trị xơ gan trên mô hình xơ gan ở chuột BALB/c được tiêm dưới da CCl4 liều với liều 2 mL/kg x 2 lần/tuần x 8 tuần.
ĐÁNH GIÁ TÁC DỤNG ĐIỀU CHỈNH RỐI LOẠN LIPID MÁU NGOẠI SINH CỦA VIÊN NANG BÀO CHẾ TỪ TỎI ĐEN, BỤP GIẤM, TRẠCH TẢ VÀ GIẢO CỔ LAM TRÊN CHUỘT CỐNG TRẮNG
Authors: Nguyễn Hoàng Ngân , Phùng Văn Bằng , Lê Hồng Phú , Trịnh Thị Hạnh , Đặng Văn Điệp , Bùi Thị Bích Vân , Đỗ Thị Hương Lan 
Published: November 2023

Mục tiêu: Đánh giá tác dụng điều chỉnh rối loạn lipid máu ngoại sinh của viên nang bào chế từ tỏi đen, bụp giấm, trạch tả và giảo cổ lam trên chuột cống trắng. Phương pháp nghiên cứu: Theo mô hình của Nguyễn Trọng Thông và CS (2014), gây rối loạn lipid chuột cống trắng Wistar bằng dầu cholesterol 10 mL/kg/24h. 50 con chuột được chia làm 5 lô; Lô 1 uống nước cất 10 mL/kg; Lô 2 uống dầu cholesterol + nước cất 10 mL/kg sau 2 giờ; Lô 3 uống dầu cholesterol + thuốc thử 336 mg/kg sau 2 giờ; Lô 4 uống dầu cholesterol + thuốc thử 672 mg/kg sau 2 giờ; Lô 5 uống dầu cholesterol + atorvastatin 10 mg/kg sau 2 giờ. Chỉ tiêu đánh giá: Triglyceride (TG), cholesterol toàn phần (TC), HDL-C, LDL-C, VLDL-C, chỉ số vữa xơ mạch (AI) tại thời điểm 0, 14 và 28 ngày. Kết quả xử lý bằng phần mềm SPSS 16.0. Kết quả: Chuột uống hỗn hợp dầu cholesterol (lô 2) có các chỉ số lipid máu và vữa xơ mạch (TG, TC, LDL-C, VLDL-C, AI) cao hơn so với ở lô chứng (lô 1). Ở các lô dùng thuốc nghiên cứu và thuốc tham chiếu (lô 3, 4, 5) các chỉ số TG, TC, LDL-C, VLDL-C, AI giảm so với lô không uống thuốc (lô 2); làm tăng HDL-C so với lô 2 tại 14 và 28 ngày (với p < 0,05). Kết luận: Ở cả 2 mức liều thuốc thử có tác dụng tốt trong điều trị rối loạn lipid máu, tương đương với lô tham chiếu dùng Atorvastatin.
Recent Advances in Genitourinary Tumors: Updates From the 5th Edition of the World Health Organization Blue Book Series
Authors: Riddle Nicole , Parkash Vinita , Guo Charles C. , Shen Steven S. , Perincheri Sudhir , Ramirez Angela Sanguino , Auerbach Aaron , Belchis Deborah , Humphrey Peter A. 
Published: November 2023

Context.—
Urinary and Male Genital Tumours is the 8th volume of the World Health Organization Classification of Tumours series, 5th edition. Released in hard copy in September 2022, it presents an update to the classification of male genital and urinary tumors in the molecular age. Building upon previous volumes in this series, significant effort has been made to harmonize terminology across organ systems for biologically similar tumors (eg, neuroendocrine tumors). Genomic terminology has been standardized and genetic syndromes covered more comprehensively. This review presents a concise summary of this volume, highlighting new entities, notable modifications relative to the 4th edition, and elements of relevance to routine clinical practice.

Objective.—
To provide a comprehensive update on the World Health Organization classification of urinary and male genital tumors, highlighting updated diagnostic criteria and terminology.

Data Sources.—
The 4th and 5th editions of the World Health Organization Classification of Tumours: Urinary and Male Genital Tumours.

Conclusions.—
The World Health Organization has made several changes in the 5th edition of the update on urinary and male genital tumors that pathologists need to be aware of for up-to-date clinical practice.
Evaluation of the Closure of Patent Ductus Arteriosus With Ibuprofen Compared to Indomethacin
Authors: Jackson Cory D. , Capino Amanda C. , Stuart Lindsay H. , Wagner Jamie L. 
Published: November 2023

OBJECTIVE
Limited data exist comparing indomethacin and ibuprofen for the treatment of patent ductus arteriosus (PDA). The objective was to compare the safety and efficacy of indomethacin and ibuprofen for treatment of PDA closure.

METHODS
This single-center, pre-test/post-test quasi-experiment included preterm infants admitted to the neonatal intensive care unit who received indomethacin (July 1, 2013–September 30, 2015) or ibuprofen (December 1, 2015–July 31, 2019) for PDA. Patients were excluded if they were thrombocytopenic, had existing kidney injury, unresolved intraventricular hemorrhage (IVH) or necrotizing enterocolitis (NEC) at treatment initiation. Data were obtained from the electronic health record. Study outcomes were complete PDA closure, degree of PDA closure, resolution of symptoms, and new-onset acute kidney injury (AKI), IVH, or NEC.

RESULTS
A total of 114 patients were included: 44 (39%) received indomethacin and 70 (61%) received ­ibuprofen. Twenty-one (21%) patients experienced successful PDA closure within 1 week: 13 (32%) indomethacin patients and 8 (13%) ibuprofen patients (p = 0.023). PDA size reduction occurred in 43 (46%) patients with 29 (25%) experiencing complete symptom resolution. Significantly more indomethacin patients compared with ibuprofen patients experienced new-onset AKI (48% vs 17%; p &lt; 0.001) and received concomitant nephrotoxins (68% vs 39%; p = 0.002). There were no significant differences in new-onset IVH or NEC.

CONCLUSIONS
Indomethacin administration successfully closed the PDA in more neonates than ibuprofen but resulted in higher rates of AKI. However, this was confounded by more frequent administration of concomitant nephrotoxins. Larger trials are needed to help elucidate the optimal drug for closure of the PDA in neonates.
Repenser les grands récits sur Marie-Anne Gaboury à partir d’une perspective wahkotowin
Authors: Gaudet Janice Cindy , Bouvier Hannah 
Published: November 2023

Notre texte vise à repenser la construction du récit de Marie-Anne Gaboury à partir d’une perspective wahkotowin (ses lois, éthiques et pratiques) afin d’établir une relation saine au territoire, avec nos relations Métis ainsi qu’avec d’autres peuples autochtones. Notre recherche contribue à valoriser la perspective féministe autochtone afin de réimaginer le récit dominant à partir d’une perspective relationnelle et de démanteler la hiérarchie des savoirs produite et reproduite. Les grands récits sur Marie-Anne Gaboury rendent invisibles le vécu et la contribution des femmes Métis, Cris, Saulteaux (le système de gouvernance matriarcale) de l’Ouest. C’est comme si son histoire était isolée des contextes social et politique des femmes du territoire et du mouvement de résistance historique et contemporain. On en vient à se demander: qui donc profite des grands récits et qui est Marie-Anne Gaboury en relation avec les femmes autochtones ou vice versa? Qui est-elle au-delà du nom d’une rue, au-delà d’être la première femme blanche/francophone dans l’Ouest, au-delà d’être la grand-mère de Louis Riel ?
Patent Ductus Arteriosus and Bronchopulmonary Dysplasia–Associated Pulmonary Hypertension
Authors: Villamor Eduardo , van Westering-Kroon Elke , Gonzalez-Luis Gema E. , Bartoš František , Abman Steven H. , Huizing Maurice J. 
Published: November 2023

ImportanceBronchopulmonary dysplasia (BPD) is often associated with pulmonary vascular disease and secondary pulmonary hypertension (PH). The pathogenesis of BPD-associated PH (BPD-PH) is complex and involves prenatal and postnatal factors that disrupt pulmonary vascular development, and patent ductus arteriosus (PDA) is a factor potentially associated with risk of BPD-PH that has been identified in very recent studies.ObjectiveTo explore the association of PDA with BPD-PH using a bayesian model-averaged (BMA) meta-analysis of studies.Data SourcesPubMed and Embase were searched up to April 2023. Key search terms included BPD and PH.Study SelectionStudies examining infants with gestational age 32 weeks or less and reporting data on PDA and risk of BPD-PH.Data Extraction and SynthesisThis study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Meta-Analysis of Observational Studies in Epidemiology reporting guidelines. Two independent reviewers extracted data, with a third reviewer checking for accuracy and completeness. Data pooling and effect size calculations were performed by BMA.Main Outcomes and MeasuresThe primary outcome was BPD-PH. BMA was used to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H1, association of PDA with BPD-HP) over the probability of the data under the null hypothesis (H0).ResultsA total of 32 studies (8513 infants) were included. BMA showed that the evidence in favor of H1 was weak for any PDA (BF10 = 2.90; 10 studies), moderate for hemodynamically significant PDA (BF10 = 3.77; 3 studies), and extreme for surgically ligated or catheter-occluded PDA (BF10 = 294.9; 16 studies). In contrast, the evidence in favor of H0 was weak for medically treated PDA (BF10 = 0.55; 6 studies). In addition, BMA found strong evidence in favor of H1 when prolonged exposure to PDA was analyzed as a dichotomous variable (BF10 = 11.80; 6 studies) and extreme evidence (BF10 = 113.60; 3 studies) when PDA exposure time was analyzed as a continuous variable.Conclusions and RelevanceIn this bayesian meta-analysis, the data suggest that prolonged exposure to PDA might be associated with increased risk of pulmonary vascular disease in extremely preterm infants. This highlights the need to monitor for PH in high-risk preterm infants with prolonged exposure to PDA and to incorporate PH risk into clinical decisions regarding PDA management.
Patient and Care Team Perspectives on Social Determinants of Health Screening in Primary Care
Authors: Rudisill A. Caroline , Eicken Meredith G.A. , Gupta Deeksha , Macauda Mark , Self Stella , Kennedy Ann Blair , Thomas Darin , Kao Elise , Jeanty Mia , Hartley Jackson 
Published: November 2023

ImportanceHealth systems in the US are increasingly screening for social determinants of health (SDOH). However, guidance incorporating stakeholder feedback is limited.ObjectiveTo examine patient and care team experiences in early implementation of SDOH screening in primary care.Design, Setting, and ParticipantsThis qualitative study included cross-sectional analysis of SDOH screenings during primary care visits from February 22 to May 10, 2022, primary care team member interviews from July 6, 2022, to March 8, 2023, and patient stakeholder engagement on June 30, 2022. The setting was a large southeastern US health care system. Eligible patients were aged 18 years or older with completed visits in primary care.ExposureScreening for SDOH in primary care.Main outcomes and MeasuresMultivariable logistic regression evaluated patient (eg, age, race and ethnicity) and care team characteristics (eg, practice type), and screening completeness. Interviews contextualized the quantitative analysis.ResultsThere were 78 928 visits in practices conducting any SDOH screening. The population with visits had a mean (SD) age of 57.6 (18.1) years; 48 086 (60.9%) were female, 12 569 (15.9%) Black, 60 578 (76.8%) White, and 3088 (3.9%) Hispanic. A total of 54 611 visits (69.2%) were with a doctor of medicine and 13 035 (16.5%) with a nurse practitioner. Most had no SDOH questions answered (75 298 [95.4%]) followed by all questions (2976 [3.77%]). Logistic regression analysis found that clinician type, patient race, and primary payer were associated with screening likelihood: for clinician type, nurse practitioner (odds ratio [OR], 0.13; 95% CI, 0.03-0.62; P = .01) and physician assistant (OR, 3.11; 95% CI, 1.19-8.10; P = .02); for patient race, Asian (OR, 1.69; 95% CI, 1.25-2.28; P = .001); Black (OR, 1.49; 95% CI, 1.10-2.01; P = .009); or 2 or more races (OR, 1.48; 95% CI, 1.12-1.94; P = .006); and for primary payer, Medicaid (OR, 0.62; 95% CI, 0.48-0.80; P &amp;lt; .001); managed care (OR, 1.17; 95% CI, 1.07-1.29; P = .001); uninsured or with Access Health (OR, 0.26; 95% CI, 0.10-0.67; P = .005), and Tricare (OR, 0.71; 95% CI, 0.55-0.92; P = .01). Interview themes included barriers (patient hesitancy, time and resources for screening and referrals, and number of questions/content overlap) and facilitators (communication, practice champions, and support for patient needs).Conclusions and RelevanceThis qualitative study presents potential guidance regarding factors that could improve SDOH screening within busy clinical workflows.
Measures of Well‐Being and Official Statistics
Authors: Maggino Filomena 
Published: November 2023

Abstract
Recently, the debate on new measures of well‐being reached a wide audience, especially thanks to the big media's “ballyhoo.”
That debate, very often accompanied by Robert Kennedy's words (March 18, 1968, speech at Kansas University), has been urged, also thanks to many prestigious initiatives, such as the commission appointed by French President in 2008 and now known through the chairs' names (Stiglitz, Sen e Fitoussi).
What is never said is that since many years, many researchers all over the world have been continuously working on defining concepts and measures of well‐being.
In many cases, the debate has been trivialized to the simple concern “what indicator can replace GDP?”

In order to measure and monitor a country's well‐being and progress, a systematic approach is needed, leading from
concept
to
measure
, to
synthesis
and then
interpretation
.

The process requires the identification of (in order):

The concepts (and their corresponding conceptual dimensions) to measure and monitor and the domains in which the concepts are measured and monitored.

The indicators including the techniques aimed at summarizing and summing up the indicators.

Interpretative and explanatory models.

This process should be an integral part of the mission of official statistics.
Developing and Running Machine Learning Software: Machine Learning Operations (MLOps)
Authors: Scutari Marco , Malvestio Mauro 
Published: November 2023

AbstractMachine learning software is fundamentally different from most other software in one important respect: it is tightly linked with data. The behavior of machine learning software is dictated as much by the data we train our models on as it is by our design choices because the information in the data is compiled into the software through the models. In a sense, models program the software automatically: developers do not completely encode its behavior in the code. Combining this idea with modern software development schools such as Agile and DevOps into MLOps has shaped how we develop and run software that incorporates probabilistic models in real‐world applications. In this article, we provide a brief overview of commonly accepted best practices for developing such software, focusing on the unique challenges that require a combination of statistical and software engineering expertise to tackle.
Parametric and Parameter‐Free Shape Moments
Authors: Shore Haim 
Published: November 2023

Abstract
Skewness and kurtosis are commonly considered sufficient representatives of distributional shape, generally represented by the third and fourth standardized central moments (moments about the mean). Certain distributions own parametric shape moments, while others do not. In particular, the normal and exponential have parameter‐free shape moments. In this article, we offer an in‐depth explanation for this phenomenon, based on Pearson skewness measure and on a new “Random‐identity Paradigm,” recently published.