bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole brain network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression
Authors: Cha Jungho , Choi Ki Sueng , Rajendra Justin K. , McGrath Callie L. , Riva-Posse Patricio , Holtzheimer Paul E. , Figee Martijn , Kopell Brian H. , Mayberg Helen S. 
Published: November 2023

AbstractOngoing experimental studies of subcallosal cingulate deep brain stimulation (SCC DBS) for treatment-resistant depression (TRD) show a differential timeline of behavioral effects with rapid changes after initial stimulation, and both early and delayed changes over the course of ongoing chronic stimulation. This study examined the longitudinal resting-state regional cerebral blood flow (rCBF) changes in intrinsic connectivity networks (ICNs) with SCC DBS for TRD over 6 months and repeated the same analysis by glucose metabolite changes in a new cohort. A total of twenty-two patients with TRD, 17 [15 O]-water and 5 [18 F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) patients, received SCC DBS and were followed weekly for 7 months. PET scans were collected at 4-time points: baseline, 1-month after surgery, and 1 and 6 months of chronic stimulation. A linear mixed model was conducted to examine the differential trajectory of rCBF changes over time. Post-hoc tests were also examined to assess postoperative, early, and late ICN changes and response-specific effects. SCC DBS had significant time-specific effects in the salience network (SN) and the default mode network (DMN). The rCBF in SN and DMN was decreased after surgery, but responder and non-responders diverged thereafter, with a net increase in DMN activity in responders with chronic stimulation. Additionally, the rCBF in the DMN uniquely correlated with depression severity. The glucose metabolic changes in a second cohort show the same DMN changes. The trajectory of PET changes with SCC DBS is not linear, consistent with the chronology of therapeutic effects. These data provide novel evidence of both an acute reset and ongoing plastic effects in the DMN that may provide future biomarkers to track clinical improvement with ongoing treatment.
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
Authors: Zhou Li , Wu Dongxiao , Zhou Yabo , Wang Dianheng , Fu Haixia , Huang Qiusha , Qin Guohui , Chen Jie , Lv Jiadi , Lai Shaoyang , Zhang Huafeng , Tang Ke , Ma Jingwei , Fiskesund Roland , Zhang Yi , Zhang Xiaohui , Huang Bo 
Published: November 2023

AbstractTumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been identified. Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) differentiation into megakaryocytes in individuals with cancer by activating the aryl hydrocarbon receptor–Runt-related transcription factor 1 (AhR–RUNX1) axis. During tumor growth, large amounts of Kyn from tumor cells are released into the periphery, where they are taken up by MEPs via the transporter SLC7A8. In the cytosol, Kyn binds to and activates AhR, leading to its translocation into the nucleus where AhR transactivates RUNX1, thus regulating MEP differentiation into megakaryocytes. In addition, activated AhR upregulates SLC7A8 in MEPs to induce positive feedback. Importantly, Kyn–AhR–RUNX1-regulated MEP differentiation was demonstrated in both humanized mice and individuals with cancer, providing potential strategies for the prevention of thrombocytosis and erythrocytopenia.
Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet
Authors: Hounchonou Harold F. , Tang Hui , Paulat Raik , Kühn Andrea , Spranger Joachim , van Riesen Christoph , Maurer Lukas 
Published: November 2023

AbstractObesity is an enormous health problem, and many patients do not respond to any of the available therapies. Deep brain stimulation (DBS) is currently investigated as a potential treatment for morbid obesity. In this study, we tested the hypothesis that high-frequency DBS targeting the nucleus accumbens (NAc) shell region reduces food intake and weight gain in mice fed a high-fat diet. We implanted male C57BL/6J mice with bilateral electrodes and a head-mounted microstimulator enabling continuous stimulation for up to 5 weeks. In successfully operated animals (n = 9 per group, high-frequency vs. sham stimulation), we investigated immediate and long-term stimulation effects on metabolic and behavioral phenotypes. Here we show that stimulation acutely induced a transient reduction in energy expenditure and locomotor activity but did not significantly affect spontaneous food intake, social interaction, anxiety or exploratory behaviors. In contrast, continuous stimulation over 5 weeks led to a decrease in food intake and thigmotaxis (the tendency to stay near walls in an open lit arena). However, chronic stimulation did not substantially change weight gain in mice fed a high-fat diet. Our results do not support the use of continuous high-frequency NAc shell DBS as a treatment for obesity. However, DBS can alter obesity-related parameters with differing short and long-term effects. Therefore, future research should employ time and context-sensitive experimental designs to assess the potential of DBS for clinical translation in this area.
Advancing IR in Underserved Regions: Interventional Radiology Simulation Near and Far
Authors: Koech Cornelius K. , Rivera Victor I. , Anton Kevin , Dixon Robert G. 
Published: November 2023

AbstractSimulation facilitates learning by imitating real-world systems or processes utilizing educational tools and models. Various fields, including business, aviation, and education use simulation for training. In healthcare, simulation provides trainees opportunities to develop procedural skills in a safe environment, building their understanding through hands-on interactions and experiences rather than passive didactics. Simulation is classified into low, medium, and high fidelity, based on how closely it mimics real-life experience. Its use in education is a valuable adjunct to instructional support and training with multiple potential benefits. Interventional radiology (IR) trainees can build technical and clinical proficiency prior to working directly on a patient. Simulation promotes experiential learning, constructivist learning, and student centeredness, thus giving students control over their learning and knowledge acquisition. More recently, the creative use of remote simulation has augmented traditional virtual didactic lectures, thereby further engaging international learners and enhancing remote collaboration. Despite the challenges to implementation, the addition of simulation in IR education is proving invaluable to supporting trainees and physicians in underserved regions.
Development of sweep frequency ultrasonic interferometer for high precision velocity measurement in liquids
Authors: Dhiman Nitin , Sharma Sahil , Piyush  , Kumar Bishan , Yadav Sanjay , Dubey P. K. 
Published: November 2023

An ultrasonic interferometer with variable separation between the transducer and reflector is widely used for the measurement of ultrasonic propagation velocity in liquids. The inherent limitation of such an interferometer is due to the mechanical movement of its reflector for ultrasonic wavelength measurement in a liquid medium. It is observed that the ultrasonic velocity measurement precision is adversely affected at higher frequencies compared to lower ones. For instance, in our experimentation, a standard deviation of ±21.5 m/s (±1.43%) was obtained for velocity measurement at 1.84 MHz with the consideration of two consecutive maxima, which increases drastically to ±76.8 m/s (±5.12%) at 9.4 MHz. These measurements can significantly be improved by considering many maxima and averaging for wavelength estimation. However, it still requires design attention and improvement, particularly for higher frequencies. In this article, a sweep-frequency based ultrasonic interferometer design with a fixed separation for liquid characterization is proposed and described. This technique overcomes the limitations of mechanical movement systems and also provides a better and uniform precision for lower as well as higher frequencies. The functionality of the developed sweep frequency method was tested in water, carbon tetrachloride, ethylene glycol, and glycerol, which shows good agreement with literature values. The velocity measurement in double distilled water by the developed technique at 1 Hz sweep resolution has shown an improved standard deviation of ±0.74 m/s (±0.05%) at 9.4 MHz.
Non–uniform decay of solutions to the incompressible magneto–micropolar fluids with/without magnetic diffusion and spin viscosity
Authors: Wu Wanping , Zhang Yinghui 
Published: November 2023

We are concerned with the long time behavior of solutions to the incompressible magneto–micropolar fluids with/without magnetic diffusion and spin viscosity in two and three dimensions. When the magnetic diffusion is absent, we show that L2–norm of fluid velocity and micro–rotational velocity vanishes and L2–norm of the magnetic field converges to a non–negative constant as time tends to infinity. Moreover, when both magnetic diffusion and spin viscosity are present and the initial data belongs to L2, we prove that the solutions decay to zero without a rate, and this non–uniform decay is optimal. The proofs are based on Fourier splitting method, low–frequency and high–frequency decomposition techniques and delicate energy estimates.
Quantum and anharmonic effects in non-adiabatic transition state theory
Authors: Mulvihill Clayton R. , Georgievskii Yuri , Klippenstein Stephen J. 
Published: November 2023

Quantitative descriptions of non-adiabatic transition rates at intermediate temperatures are challenging due to the simultaneous importance of quantum and anharmonic effects. In this paper, the interplay between quantum effects—for motion across or along the seam of crossing—and anharmonicity in the seam potential is considered within the weak coupling limit. The well-known expression for quantized 1-D motion across the seam (i.e., tunneling) in the linear terms approximation is derived in the thermal domain using the Lagrangian formalism, which is then applied to the case when tunneling is distributed along the seam of crossing (treating motion along the seam classically). For high-frequency quantum modes, a vibrationally adiabatic (VA) approach is developed that introduces to the non-adiabatic rate constant a factor associated with high-frequency wavefunction overlap; this approach treats the high-frequency motion along the seam quantum mechanically. To test these methodologies, the reaction N2O ↔ N2 + O(3P) was chosen. CCSD(T)-F12b/cc-pVTZ-F12 explorations of the 3A′-1A′ seam of N2O revealed that seam anharmonicity has a strong effect on the rate constant (a factor of ∼20 at 2000 K). Several quantum effects were found to be significant at intermediate/lower temperatures, including the quantum N–N vibration that was coupled with seam anharmonicity using the VA approach. Finally, a 1-D approximation to non-adiabatic instanton theory is presented to estimate the validity limit of the linear terms model at low temperatures (∼250 K for N2O). We recommend that the assumptions built into many statistical theories for non-adiabatic reactions—harmonic behavior, classical motion, linear terms, and weak coupling—should be verified on a case-by-case basis.
Design and study of an eccentric wheel drive-based rotating piezoelectric energy harvester
Authors: Liu Xuejin , Wang Hongxin , Lv Xingqian , Zhang Limin , He Lipeng 
Published: November 2023

A nonlinear rotating piezoelectric energy harvester (N-RPEH) driven by eccentric wheels is proposed to collect rotational energy in the environment. Driven by external rotational motion, an eccentric wheel converts rotational motion into linear motion and realizes electrical energy output through magnetic coupling. To increase the effectiveness of the equipment’s energy conversion process, this article aims to transform the rotational motion of an eccentric wheel into a linear motion of a motion board. The effects of the motion board’s length L, the cylindrical magnet’s height H, and the mass block M at the piezoelectric patch’s end on the output performance of N-RPEH are explained by theoretical modeling and simulation. Through theoretical analysis, simulation, and experiment, it is found that when L = 120 mm, H = 6 mm, and M = 5.0 g (medium mass), the output voltage reaches the maximum of 14.16 V. Under this parameter, N-RPEH can produce a maximum power of 7.0688 mW when the external resistance value is 2 kΩ. Application experiments show that N-RPEH can light up 60 light-emitting diodes. Therefore, the proposed N-RPEH can effectively collect rotational energy and has a wide range of potential applications in wireless sensor networks.
Eine vergessene Ausgabe von Ciceros De natura deorum
Authors: Gawlick Günter , Lorenz Stefan 
Published: November 2023

Abstract
This article wants to recall a hitherto unnoticed edition of Cicero’s De Natura Deorum, which the
classical philologist Matthäus Dresser (1536–1615) published with an extensive commentary. This edition, however, represents a remarkable
peculiarity within the reception history of Cicero’s text, since Dresser neither claims to be a philologist, interested in textual
criticism, nor a neutral historian of the philosophy of religion. Rather, as an apologetically oriented Protestant in times of confessional
conflict, he is concerned with the argumentative validity of the different answers to the questions discussed in Cicero’s text: Do gods
exist? What qualities do they have? What activities do they display? And which relevance do these answers have for Christian monotheism?
Hence, we may speak of a selective commentary, first and foremost interested in the truth or falsehood of the various answers to these main
questions, in order to set contemporary readers (especially scholars and students) on the right track and to save them from severe religious
errors. Dresser aims to achieve his goal by adding to the text not only extensive Annotationes, but also an introductory
Argumentum to each of the three Ciceronian books of De Natura Deorum. He also gives two
Disputationes (in the form of theses) at the end of each book, which provide a résumé and further guidance on
interpretation. Thus he firmly rejects the atomism of Epicureanism and its denial of Providence, as explained in the first book. Dresser has
to take a differentiated view of the views of Stoicism as presented in the second book: Besides many beneficial doctrines, this school of
philosophers also holds fatalistic and pantheistic views which have to be rejected as dangerous to the Christian faith. As the sceptic Cotta
radically rebukes the religious views of Epicureanism in the third book, but also attacks in large part Stoic theism and its idea of
providence, which is also dear to Dresser’s heart, he is forced to oppose academic scepticism. This gives rise to a “theodicy” avant la
lettre by Dresser, since Cottas denial of providence had also argued with the existence of evil in God’s creation. The Epicurean conceptions
of God are thus not an option. Those of Stoicism are acceptable if purged of dangerous elements. Scepticism in its radical academic form
must be eliminated by argument. In this article, these features of Dresser’s Annotationes and
Disputationes are described and analysed in detail. Important parts of his commentaries are quoted in the author’s
translation. Completely translated are the Disputationes 1 and 2 to Book III, dealing with the sceptical ’epoché’ or
retention of judgement. Thus, the contribution not only represents a unique example of the reception of Cicero’s De Natura
Deorum in the age of confessionalism, but also gives an insight into the reception of the three Hellenistic schools of philosophy
in the early modern period in general, especially that of scepticism.
Cognitive underpinnings of the meaning of Spanish estar
Authors: Piñango María Mercedes , Fuchs Martín 
Published: November 2023

Abstract
The Spanish copula verb estar is currently taking part in two of the most well-known paths of
semantic change across different dialectal varieties of Spanish: (a) as a main copula verb, in its encroachment on the domain of
ser, and (b) as the auxiliary in the Present Progressive marker, as it encroaches in the domain of the Simple
Present form (i.e., Sánchez-Alonso 2018; Fuchs
2020). Here we argue for the hypothesis that estar’s participation in both paths of change is not
coincidental. Focusing on the copular use, we present arguments for the proposal that estar’s encroachment is
connected to its lexico-conceptual structure, which, under specific communicative pressures, is afforded greater conversational
informativity, thus systematically expanding its licensing contexts and, as a result, bolstering its use. Evidence consistent with
this analysis emerges from use variation for estar across several dialects of Spanish, both in its copular and
auxiliary uses.
Temperature dependence of the thermal conductivity of hydroxide catalysis bonds between silicon substrates
Authors: Masso Reid Mariela , Haughian Karen , Cumming Alan V , Faller James , Hammond Giles , Hough James , van Veggel Anna-Maria , Rowan Sheila 
Published: November 2023

Abstract
Future generations of gravitational wave detectors plan to use cryogenics in order to further reduce thermal noise associated with the mirror test masses and their suspensions. It is important that the thermal conductivity of candidate materials for these mirror suspension systems, and any additional thermal resistance associated with the required bonding/jointing, is characterised. Results are presented here for composite single-crystal silicon substrates, with multiple hydroxide catalysis bonds present, in order to assess the thermal conductivity of the bond layers. An average bond thickness of

460

nm is observed within the oxide-bond-oxide interfaces, with a calculated thermal conductivity rising from

0.013
→
0.087

Wm−1K−1 across a temperature range of

9
→
300

K. This confirms that the thermal conductance through hydroxide catalysis bonds, with geometries being considered for third generation gravitational wave detectors operating at 20 K or 125 K, would have a negligible impact on the required heat extraction for cryogenic operation. Therefore, the use of hydroxide catalysis bonding, as successfully demonstrated within room temperature gravitational wave detectors, remains an attractive solution for building future cryogenic instruments with reduced thermal noise and enhanced astrophysical reach.
Asymmetric solitons induced by transition and beating effects
Authors: Li Xiao-Lin , Meng Ling-Zheng , Zhao Li-Chen 
Published: November 2023

Abstract
We investigate the dynamics of beating solitons in a two-component Bose–Einstein condensate with tunable Rabi coupling strength. Our results demonstrate that the balance between transition and beating effects permits the emergence of a novel family of asymmetric solitons in the symmetric physical settings. We derive the exact analytical solutions for them, which primarily consist of one bright soliton and one dark soliton element. The analytical solutions provide us with precise balance conditions required for the formation of asymmetric solitons. We also show that the degree of asymmetry can be effectively manipulated by adjusting the background density flow of dark soliton element, initial relative phase between two soliton elements, and their width. Furthermore, we discuss the oscillation behavior of asymmetric solitons in a harmonic potential, and the interaction between them.
Topologically originated optical analog of electromagnetically induced reflectance in Dirac semi-metal based photonic structure
Authors: C H Meghna , Mathew Don , Mathew Vincent 
Published: November 2023

Abstract
The optical analog of the electromagnetically induced reflectance (EIR) effect was theoretically studied in an active topological photonic structure comprising Dirac semi-metal and topological photonic crystal. The destructive interference between the optical Tamm state and topological edge state results in an induced reflection. It was known that the EIR-like effect occurs in a system having a radiative state and a metastable state. Topological protection is used here to achieve a metastable state, so an effective design of the EIR-like effect was possible. The observed EIR-like effect was modeled as a coupled oscillator system. The use of bulk Dirac semi-metal makes this an active photonic system at terahertz frequencies where the Fermi energy can act as a tunable and controlling parameter through which the induced transparency can be varied.
Robust photogalvanic effect, full spin polarization and pure spin current in the BiC photodetector by vacancy and substitution-doping
Authors: Fu Xi , Lin Jian , He Chaozheng , Liao Wenhu , Guo Jiyuan , Li Xiaowu , Gao Haixia 
Published: November 2023

Abstract
The photogalvanic effects (PGEs) in low-dimensional devices have attracted great interests recently. Herein, based on non-equilibrium Green’s function combined with density functional theory, we investigated spin-dependent PGE phenomena in the BiC photodetector with the linearly polarized light and zero bias. Due to the presence of strong spin–orbit interaction (SOI) and C
3v
symmetry for the BiC monolayer, the armchair and zigzag BiC photodetectors can produce robust spin-dependent PGEs which possess the cos(2θ) and sin(2θ) relations on the photon energies, respectively. Especially, the pristine armchair and armchair Bi-vacancy BiC photodetectors can produce fully spin polarization, and pure spin current was found in the pristine armchair and zigzag BiC photodetector, respectively. Furthermore, after introducing the Bi-vacancy, C-vacancy, Bi-doping and C-doping respectively, the BiC photodetector can produce higher spin-dependent PGEs for their C

s
symmetry. Additionally, the behaviors of spin-dependent photoresponse are highly anisotropic which can be tuned by the photon energy. This work suggested great potential applications of the BiC monolayer on PGE-driven photodetectors in low energy-consumption optoelectronics and spintronic devices.