bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond the norm: exploring the uncommon squamous cell carcinoma of the prostate using a Saudi tumor registry
Authors: Alasker Ahmed , Shafqat Areez , Sabbah Belal Nedal , Alghafees Mohammad , Al Saud Aljoharah Adeeb , Aljabi Nasouh , Altaweel Khalid Mazin , Alhumaidan Raghad , Musalli Ziyad F. , Almanie Abdulaziz , Abu Alqam Rakan , Bin Ofisan Salman 
Published: October 2023

Background:
Squamous cell carcinoma (SCC) of the prostate has limited treatment choices and portends a dismal prognosis with an average survival time of ~14-months. This study provides a descriptive overview of SCC of the prostate in Saudi Arabia.

Materials and Methods:
A retrospective cohort study of patients diagnosed with prostatic SCC between 1 January 2008 and 31 December 2017. Information on demographic and tumor characteristics and the survival of patients was collected from the Saudi Cancer Registry. Survival was depicted through Kaplan–Meier plots. Fisher’s exact test was used to assess the association between categorical variables and death, while a Wilcoxon rank sum test was applied for numerical variables.

Results:
Out of a larger subset of 3607 patients, 16 patients were diagnosed with prostatic SCC, of which half resided in the Central region (50.0%) and most (81.2%) were aged greater than or equal to 60 years. Most patients (62.6%) had poorly differentiated (grade III, 43.8%) lesions, and 50% of cases were metastatic at diagnosis. 62.5% of patients died, all residing in the Eastern and Central regions. Regional extension (75.0%) and distant metastasis (87.5%) were significantly associated with death compared to localized lesions (0.0%) (P=0.022). The 5-year survival rate in our study was 33%.

Conclusion:
The present study is the first to describe the characteristics of prostatic SCC in Saudi Arabia. Our results are consistent with prior studies showing that prostatic SCC is often high-grade and metastatic at diagnosis, conferring a poor prognosis.
Early small bowel obstruction as a complication of abdominal drain in colon cancer surgery: a case report and literature review
Authors: Nguyen Minh Thao , Pham Anh Vu 
Published: October 2023

Introduction:
Early postoperative small bowel obstruction (EPSBO) is an obstruction that occurs within 4 weeks after the initial surgery. Routine prophylactic abdominal drainage does not provide any benefit in colon cancer surgery. The cause of EPSBO due to the abdominal drainage tube is infrequent.

Case presentation:
A 72-year-old male patient was diagnosed with sigmoid carcinoma and underwent laparoscopic left colectomy. A surgical drain was placed in the pouch of Douglas through the incision of the right iliac fossa trocar site. On the fourth day, he began to flatus, and the abdominal pain decreased. However, on the ninth day after surgery, the patient had more abdominal pain, could not pass gas and defecate, and the abdomen was more distended. An abdominal computed tomography (CT) scan showed a dilated loop of the small intestine above the transition site with a drainage sonde and no dilation of the loop below the sonde. The patient was indicated to remove the sonde. He could pass gas and defecate the next day again and was relieved of the abdominal distention.

Discussion:
Once an EPSBO is considered, it is essential to think of the bowel obstruction caused by the drainage tube in the case of abdominal drainage. It is necessary to have a contrast CT scan to examine.

Conclusion:
EPSBO due to intra-abdominal drainage is a rare condition that presents a challenge in diagnosis and treatment. Diagnosis usually begins on the fourth postoperative day, mainly in operations in the lower transverse mesentery, including drainage placement after laparoscopic surgery.
Long-term Outcomes of Robot-assisted versus Laparoscopic Surgery for Colon Cancer: A Nationwide Register-based Cohort Study
Authors: Cuk Pedja , Kaalby Lasse , Deding Ulrik , Al-Najami Issam , Ellebæk Mark Bremholm 
Published: October 2023

Objective:
To determine long-term survival in patients undergoing robot-assisted (RAS) or laparoscopic surgery (LAS) for colon cancer.

Background:
The potential long-term benefits of RAS compared to LAS for colon cancer are not well examined. Using a register-based approach, we aimed to compare these two surgical platforms in an analysis of long-term outcomes, including recurrence-free survival and all-cause- and colon cancer-specific mortality.

Methods:
A nationwide register-based cohort study of patients with Union for International Cancer Control (UICC) stage I-III colon cancer undergoing planned RAS or LAS from 2010 through 2018. Patient demographic, clinical, and pathological data were retrieved from Danish national registers. Survival- and recurrence rates were estimated by Cox proportional hazard multivariate regression analysis adjusting for baseline covariates.

Results:
A total of 7,565 patients (LAS=6,905 (91%) and RAS=660 (9%)) were included in the complete case survival analysis. Patients undergoing LAS had a significantly increased risk of cancer recurrence (LAS=1,178 (17.1%), RAS=82 (12.4%), P=0.002) with a mean follow-up time of 4.93 years (standard deviation 2.47). The survival analysis of recurrence-free survival favored RAS (hazard ratioadjusted=0.80, 95% confidence interval [0.64-1.00], P=0.049). No associations between the two surgical platforms were evident regarding all-cause (hazard ratioadjusted=0.98, 95% confidence interval [0.82-1.17], P=0.783) or colon cancer-specific mortality (hazard ratioadjusted=0.89, 95% confidence interval [0.67-1.18], P=0.405).

Conclusion:
Adopting RAS for colon cancer was associated with improved recurrence free-survival. However, it did not cause a lower all-cause- or colon cancer-specific mortality.
Granular hydrogels improve myogenic invasion and repair after volumetric muscle loss
Authors: Tanner Gabrielle I. , Schiltz Leia , Figueiredo Marxa L. , Qazi Taimoor H. 
Published: October 2023

AbstractSkeletal muscle injuries including volumetric muscle loss (VML) are marked by excessive scarring and functional disability that inherent regenerative mechanisms are unable to reverse. Despite high prevalence in civilian and military populations, there is currently no effective treatment for VML but bioengineering interventions such as biomaterials that fill the VML defect to support tissue growth and repair are a promising strategy. However, traditional biomaterials developed for this purpose are rigid, non-porous constructs that hinder cell infiltration. In the present study, we test the effects of granular hydrogels on muscle repair - hypothesizing that their inherent porosity will support the invasion of native myogenic cells and their flowability will permit conformable filling of the defect site, leading to effective muscle repair. We used photocurable hyaluronic acid crosslinked with matched muscle stiffness to prepare small or large particle fragments via extrusion fragmentation and facile size sorting. In assembled granular hydrogels, particle size and degree of packing significantly influenced pore features including porosity, pore size, and pore density, as well as rheological behavior including storage moduli and yield strain. We tested the ability of granular hydrogels to support early-stage (satellite cell invasion) and late-stage (myofiber invasion) muscle repair compared to bulk hydrogels in a VML injury model in the tibialis anterior (TA) muscles of 12-14 week old mice. Histological evaluation revealed granular hydrogels supported these regenerative processes while control bulk hydrogels restricted them to the gel-tissue interface in line with the absence of invading cells. Together, these results highlight the promising potential of injectable and porous granular hydrogels in supporting endogenous repair after severe muscle injury.
Behavioural determinants of health-care utilisation among elderly population: a cross-sectional analysis from Punjab
Authors: Kansra Pooja , Khadar Amiya Abdul 
Published: October 2023

Purpose
Population ageing is a demographic transition and burdens every country’s health sector. A lack of social security combined with low government health-sector spending has made health-care utilisation difficult among elderly in many developing countries like India. This makes population ageing a global phenomenon for policymakers, researchers and stakeholders to discuss and debate in 21st century. The purpose of this paper is to examine the behavioural determinants of health-care utilisation among elderly population in Punjab.

Design/methodology/approach
This study examines health-care utilisation among the elderly population in Punjab. A structured questionnaire was used to collect the data in the state of Punjab, with a multi-stage stratified random sample of 385 respondents. Logit regression was used to analyse the association between several behavioural factors like age, gender, place of residence, source of livelihood, education and frequency of visits with health-care utilisation among elderly aged 60 and above.

Findings
This study revealed that gender, age, place of residence, source of livelihood, education and frequency of visits were significant determinants of health-care utilisation among elderly population.

Originality/value
This study directs the need to improve health-care utilisation in a country, reducing inequalities that exist among the elderly population with respect to socio-economic and demographic differences.
The effect of footbath applied to patients receiving hemodialysis treatment on comfort, fatigue, and dialysis symptoms: A randomized controlled study
Authors: Güler Sevil , Şahan Seda , Ülker Türkan , Sipahioğlu Murat Hayri 
Published: October 2023

AbstractIntroductionThis study aimed to evaluate the effect of warm water footbaths on comfort, fatigue, and dialysis symptoms in patients undergoing hemodialysis.MethodsData were collected from a total of 58 patients, 31 in the intervention group and 27 in the placebo group. The data in the study are collected using the intervention and control group informed volunteer Form, Patient Demonstration Form, foot Bath Application Monitoring Chart, fatigue VAS Scale Form, Dialysis Symptom Index, and Hemodialysis Comfort Scale (HCS).ResultsIn the second follow‐up in the intervention group, HCS was determined to significantly increase all sub‐size and total score averages by the first trace (p < 0.05). VAS fatigue point averages were significantly lower (p < 0.05) in the intervention group.ConclusionIt was determined that the footbath applied to patients who received hemodialysis treatment increased comfort and reduced fatigue and dialysis symptoms.
Enhanced expression of parvalbumin and perineuronal nets in the medial prefrontal cortex after extended‐access cocaine self‐administration in rats
Authors: Wingert Jereme C. , Anguiano Jonathan N. , Ramos Jonathan D. , Blacktop Jordan M. , Gonzalez Angela E. , Churchill Lynn , Sorg Barbara A. 
Published: October 2023

AbstractThe medial prefrontal cortex (mPFC) drives cocaine‐seeking behaviour in rodent models of cocaine use disorder. Parvalbumin (PV)‐containing GABAergic interneurons powerfully control the output of the mPFC, yet few studies have focused on how these neurons modulate cocaine‐seeking behaviour. Most PV neurons are surrounded by perineuronal nets (PNNs), which regulate the firing of PV neurons. We examined staining intensity and number of PV and PNNs after long‐access (6 h/day) cocaine self‐administration in rats followed by either 8–10 days extinction ± cue‐induced reinstatement or short‐term (1–2 days) or long‐term (30–31 days) abstinence ± cue‐induced reinstatement. The intensity of PNNs was increased in the prelimbic and infralimbic PFC after long‐term abstinence in the absence of cue reinstatement and after cue reinstatement following both daily extinction sessions and after a 30‐day abstinence period. PV intensity was increased after 30 days of abstinence in the prelimbic but not infralimbic PFC. Enzymatic removal of PNNs with chondroitinase ABC (ABC) in the prelimbic PFC did not prevent incubation of cue‐induced reinstatement but decreased cocaine‐seeking behaviour at both 2 and 31 days of abstinence, and this decrease at 31 days was accompanied by reduced c‐Fos levels in the prelimbic PFC. Increases in PNN intensity have generally been associated with the loss of plasticity, suggesting that the persistent and chronic nature of cocaine use disorder may in part be attributed to long‐lasting increases in PNN intensity that reduce the ability of stimuli to alter synaptic input to underlying PV neurons.
How customer mistreatment hinders employee sleep quality and next‐morning vigor: The effects of affective rumination and mindfulness
Authors: Zhang Hui , Zhou Zhiqing E. , Zhang Li , Liu Yanjun , Shi Yanwei 
Published: October 2023

AbstractCustomer mistreatment as a common workplace stressor in the service industry has detrimental effects on service employees. Drawing on cognitive theories of rumination, the current study examined the effect of daily customer mistreatment experience on employee recovery outcomes (sleep quality and next‐morning vigor) through affective rumination. Further, we investigated the moderating role of trait mindfulness on the relationship between customer mistreatment and employee affective rumination. With 390 matched time‐lagged daily observations collected from 107 fulltime in‐patient nurses across five working days, our multilevel analyses revealed that daily customer mistreatment experience at work was negatively related to employee sleep quality on the same night and vigor in the next morning via affective rumination and that employee's affective rumination at the end of work and sleep quality at night sequentially mediated the relationship between daily experience of customer mistreatment and morning vigor. Besides, trait mindfulness buffered the relationship between daily customer mistreatment and affective rumination. These findings shed light on the understanding of the mechanisms between customer mistreatment and employee recovery states and potentially malleable individual characteristics that might mitigate the negative effects of customer mistreatment.
Impact of community health workers on quality of life in adolescents and young adults with sickle cell disease: The SHIP‐HU study
Authors: Sisler India , McClish Donna K. , Villella Anthony , Valrie Cecelia , Smith Wally R. 
Published: October 2023

SummaryHealth‐related quality of life (HRQoL) is an important outcome for patients with sickle cell disease (SCD). It is often poor compared with other chronic medical conditions or measured as a multidomain disease‐specific construct. We previously reported outcomes in the Start Healing in Patients with Hydroxyurea (SHIP‐HU) randomized controlled trial in adolescents and adults with SCD at six clinical sites. Besides the primary outcomes, we also measured HRQoL as a secondary outcome. Patients in the intervention arm were each assigned community health workers (CHWs) who provided case management services. CHW services were independent of medical management, and medical managers were blinded to the study arm. Patients in the control arm received only standard of care. We hypothesized that having a CHW would improve HRQoL in patients enrolled in SHIP‐HU. We did not find significant differences between domains of HRQoL in the two study arms. Possible explanations include selection bias of enrolled versus unenrolled patients, selection bias of sites, medical providers and medical management, enforced blinding, and a lack of cooperation between medical managers and CHWs. The importance of CHWs and HRQoL is nonetheless recognized based on the literature. Future interventions on HRQoL in SCD should consider alternative study designs and multimodal interventions.
Oral and systemic health in Singapore: Revisiting the past to define the future
Authors: Nascimento Gustavo G. , Balan Preethi , Alves‐Costa Silas , Bitencourt Fernando Valentim , Kalhan Ashish C. , Leite Fabio R. M. 
Published: October 2023

AbstractObjectivesThis study aimed to identify studies exploring oral and systemic conditions using Singapore data.MethodsStudies were searched using the databases PubMed, Embase and Web of Science, with no publication date or language restrictions. Studies analysing Singaporean data were included in this review.ResultsSix domains were identified: pregnancy and gingivitis; tooth eruption, dental caries and early‐life factors; Crohn's disease and oral microbiome; diabetes and periodontal diseases; number of teeth, chewing ability and cognitive status; and oral health and pneumonia. Using data from Singapore, oral‐systemic studies have prompted reflections on the aetiopathogenesis of oral disorders, such as common causes connecting oral and systemic chronic conditions. Moreover, it is speculated whether oral conditions could be used as a marker to predict future systemic diseases or whether early‐life factors could affect the development of oral and systemic immune responses.ConclusionsWhile Singapore provides opportunities to explore challenges connected to healthy ageing, it also explores health development in many stages of life. Singapore has been prioritizing investigations on a healthier life, and new initiatives are paving the way for oral health research across the lifespan.
Does the age of compensation committee members matter for CEO compensation?
Authors: Li Yiwei , Clements Michael , Padgett Carol , Zhang Xiu‐Ye 
Published: October 2023

AbstractResearch Question/IssueWe examine the impact of the age of compensation committee (CC) members on CEO compensation. Sociological theory suggests that age is a significant demographic factor influencing behavior. We argue that monitoring intensity increases with age because older directors are more likely to commit to their fiduciary duties.Research Findings/InsightsUsing FTSE 350 firms for the period 2002 to 2017, we find that CC members' age is negatively associated with the level of CEO pay but positively associated with pay–performance sensitivity after controlling for risk aversion attitude, experience in board monitoring, knowledge of the firm, and other firm and CEO characteristics. The relationships remain robust to alternative measures for age and compensation, using two‐stage least squares and high‐dimensional fixed effects models. Consistent with the view that older individuals tend to hold higher ethical standards and concomitant closer monitoring, we find that age effects are sensitive to the influence of ethical factors and are strongest for those firms for which intense monitoring is most needed. This suggests that age operates via older directors carrying out their roles more assiduously. We further show that our findings are less likely to be driven by director reputational effects, and the relationship between CC member age and CEO compensation persists even when we control for multiple dimensions of culturally inherited attributes of the CC members.Theoretical/Academic ImplicationsDespite the large literature on the influence of demographic characteristics on corporate governance, this study is the first on the monitoring effect of CC members' age. It contributes to the literature on the influence of demographic characteristic. It also contributes to the literature on CEO compensation by identifying a demographic factor—age—as a determinant of CEO pay, after controlling for the economic and corporate governance variables of the firm.Practitioner/Policy ImplicationsThis study highlights the role of demographic factors in explaining the monitoring of the CEO compensation contracting process and provides timely evidence on the recent regulatory changes.
Multi‐tissue transcriptome‐wide association study reveals susceptibility genes and drug targets for insulin resistance‐relevant phenotypes
Authors: Duan Yuan‐Yuan , Ke Xin , Wu Hao , Yao Shi , Shi Wei , Han Ji‐Zhou , Zhu Ren‐Jie , Wang Jia‐Hao , Jia Ying‐Ying , Yang Tie‐Lin , Li Meng , Guo Yan 
Published: October 2023

AbstractAimGenome‐wide association studies (GWAS) have identified multiple susceptibility loci associated with insulin resistance (IR)‐relevant phenotypes. However, the genes responsible for these associations remain largely unknown. We aim to identify susceptibility genes for IR‐relevant phenotypes via a transcriptome‐wide association study.Materials and MethodsWe conducted a large‐scale multi‐tissue transcriptome‐wide association study for IR (Insulin Sensitivity Index, homeostasis model assessment‐IR, fasting insulin) and lipid‐relevant traits (high‐density lipoprotein cholesterol, triglycerides, low‐density lipoprotein cholesterol and total cholesterol) using the largest GWAS summary statistics and precomputed gene expression weights of 49 human tissues. Conditional and joint analyses were implemented to identify significantly independent genes. Furthermore, we estimated the causal effects of independent genes by Mendelian randomization causal inference analysis.ResultsWe identified 1190 susceptibility genes causally associated with IR‐relevant phenotypes, including 58 genes that were not implicated in the original GWAS. Among them, 11 genes were further supported in differential expression analyses or a gene knockout mice database, such as KRIT1 showed both significantly differential expression and IR‐related phenotypic effects in knockout mice. Meanwhile, seven proteins encoded by susceptibility genes were targeted by clinically approved drugs, and three of these genes (H6PD, CACNB2 and DRD2) have been served as drug targets for IR‐related diseases/traits. Moreover, drug repurposing analysis identified four compounds with profiles opposing the expression of genes associated with IR risk.ConclusionsOur study provided new insights into IR aetiology and avenues for therapeutic development.
Silo‐Busting to Create Great Experiences for the Internet of Things
Authors: Desbarats Gus 
Published: October 2023

IOT design requires an overall customer‐experience, service‐design approach that covers the end‐to‐end customer journey. That includes real‐time, coordinated design across the object, an app, a web account, and the touch‐points that help with set‐up.Designing in the age of the Internet of Things is not another kind of design, but it certainly challenges some classic design roles and methods.
White matter changes in young and middle‐aged males with chronic prostatitis/chronic pelvic pain syndrome: Tract‐based spatial statistics analysis
Authors: Lan Xi , Zhu Xin‐Yi , Bai Wei‐Xian , Liu Hui‐Ping , Wang Hui , Dun Wang‐Huan , Guo Chen‐Guang , Zhang Ming , Niu Xuan 
Published: October 2023

AbstractThe supraspinal mechanism plays a key role in developing and maintaining chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, it is not clear how white matter changes in young and middle‐aged males with CP/CPPS. In this cross‐sectional study, 23 CP/CPPS patients and 22 healthy controls (HCs) were recruited. Tract‐based spatial statistics was applied to investigate the differences in diffusion tensor imaging metrics, including fractional anisotropy (FA), mean diffusion (MD), radial diffusion (RD) and axial diffusion (AD), between CP/CPPS patients and HCs. The study also examined the association between white matter alterations and clinical variables in patients using correlation analysis. Compared with HCs, patients showed decreased FA, MD, RD and AD in the body and genu of the corpus callosum and right anterior corona radiata. In addition, they showed increased FA along with decreased MD, RD and AD in the left posterior limb of the internal capsule (PLIC‐L), left external capsule and left cerebral peduncle. The FA of PLIC‐L was negatively correlated with disease duration (r = −.54, corrected p = .017), while MD and RD were positively correlated (r = .45, corrected p = .042; r = .57, corrected p = .017). These results suggest that CP/CPPS is associated with extensive changes in white matter tracts, which are involved in pain processing. In particular, the FA, MD and RD values in the PLIC‐L were correlated with the disease duration, indicating that the long‐term course of CP/CPPS may have effects on the white matter microstructure of the pain perception pathways.