bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, pharmacokinetics and efficacy of a subcutaneous recombinant FVIII (OCTA101) in adult patients with severe haemophilia A
Authors: Lissitchkov Toshko , Jansen Martina , Bichler Johann , Knaub Sigurd 
Published: November 2023

AbstractIntroductionRegular, prophylactic intravenous (i.v.) FVIII can be challenging for some patients with haemophilia A. Subcutaneous (s.c.) FVIII administration could provide an alternative treatment option with greater convenience and without the complications associated with venous access.AimTo assess the safety, pharmacokinetics (PK), bioavailability and efficacy of s.c. OCTA101, a recombinant FVIII with a recombinant von Willebrand factor fragment dimer.MethodsThis was a single‐centre, prospective, open‐label, phase I/II study (NCT04046848). Previously treated male patients (≥18 years) with severe haemophilia A were eligible for the study. The primary objective of the study was to assess the safety (including immunogenicity) of OCTA101. Secondary objectives included assessments of PK, bioavailability, and the efficacy of prophylaxis.ResultsThirty patients were treated with OCTA101. FVIII inhibitors developed in five (16.7%) patients during daily prophylaxis with 40–60 IU/kg (three cases) and 12.5 IU/kg (two cases) OCTA101. The trial was therefore terminated. OCTA101 had a 2.5‐fold longer terminal half‐life compared with i.v. rFVIII, and bioavailability was 16.6%. Efficacy data at study termination indicated that daily prophylaxis with 40–60 IU/kg OCTA101 was efficacious in the absence of FVIII inhibitors.ConclusionsDespite promising PK and efficacy results, the trial was terminated due to the incidence of FVIII inhibitors. The occurrence of inhibitors at two dose levels suggests that their development may be related to the subcutaneous route of administration.
Consumers' behavioral intention toward online shopping in the post‐COVID‐19 period
Authors: Khatoon Sabiha , Anwar Imran , Shamsi Mushahid Ali , Chaudhary Asiya 
Published: November 2023

AbstractInfectious COVID‐19 transformed the world overnight, freezing all physical activities and forcing the majority toward online mode. Technology came up as a savior to alleviate the consequences of COVID‐19 on the economy, causing a rapid transformation in consumers' behavior, and an overall jump in the sale of e‐commerce could be witnessed globally. This paper aims to explore the factors that caused the transformation in consumers' behavioral attitude (AT) and intention toward online shopping (BITOS). The study integrates the TPB and UTAUT models while adding two additional variables, namely, perceived risks (PR) and perceived benefits (PB), to predict consumers' BITOS. A survey was conducted to collect a sample of 402 consumers Aligarh city, and the National Capital Region of India using the mall intercept sampling method. The data were analysed to establish the measurement model and test the hypothesized structural model with the Smart‐PLS software. The study's findings confirmed that PB, subjective social norms, perceived ease of use, and perceived usefulness positively affect AT and BITOS, whereas PR does not influence AT and BITOS. The study also indicated that AT has a positive effect on BITOS. Concerning AT, it does not mediate the relationship between PR and BITOS; however, it mediates between the direct link PB and BITOS, making it stronger. The study's findings help the E‐commerce industry understand consumers' transformed attitudes/intentions and restructure their strategies to strengthen their online business further. Despite its regional and design limitations, it contributes significantly to the current research on online shopping behavior in India during COVID‐19.
Transmissibility of severe acute respiratory syndrome coronavirus 2 among household contacts of coronavirus disease 2019‐positive patients: A community‐based study in India
Authors: Sreedevi Aswathy , Mohammad Ahmad , Satheesh Mini , Ushakumari Anuja , Kumar Anil , Raveendran Geetha , Narayankutty Saritha , Gopakumar Soumya , Rahman Anisur , David Sachin , Mathew Minu Maria , Nair Prem 
Published: November 2023

AbstractBackgroundThis study identified the risk factors for severe acute respiratory syndrome coronavirus 2 infection among household contacts of index patients and determined the incubation period (IP), serial interval, and estimates of secondary infection rate in Kerala, India.MethodsWe conducted a cohort study in three districts of Kerala among the inhabitants of households of reverse transcriptase polymerase chain reaction‐positive coronavirus disease 2019 patients between January and July 2021. About 147 index patients and 362 household contacts were followed up for 28 days to determine reverse transcriptase polymerase chain reaction positivity and the presence of total antibodies against SARS‐CoV‐2 on days 1, 7, 14, and 28.ResultsThe mean IP, serial interval, and generation time were 1.6, 3, and 3.9 days, respectively. The secondary infection rate at 14 days was 43.0%. According to multivariable regression analysis persons who worked outside the home were protected (adjusted odds ratio [aOR], 0.45; 95% confidence interval [CI], 0.24–0.85), whereas those who had kissed the coronavirus disease 2019‐positive patients during illness were more than twice at risk of infection (aOR, 2.23; 95% CI, 1.01–5.2) than those who had not kissed the patients. Sharing a toilet with the index patient increased the risk by more than twice (aOR, 2.5; 95% CI, 1.42–4.64) than not sharing a toilet. However, the contacts who reported using masks (aOR, 2.5; 95% CI, 1.4–4.4) were at a higher risk of infection in household settings.ConclusionsHousehold settings have a high secondary infection rate and the changing transmissibility dynamics such as IP, serial interval should be considered in the prevention and control of SARS‐CoV‐2.
Transmissibility and severity of COVID‐19 in a humanitarian setting: First few X investigation of cases and contacts in Juba, South Sudan, 2020
Authors: Lako Richard Lino Loro , Meagher Niamh , Wamala Joseph Francis , Ndyahikayo John , Ademe Tegegne Ayesheshem , Olu Olushayo Oluseun , Price David J. , Rajatonirina Soatiana , Farley Elise , Okeibunor Joseph Chukwudi , Mize Valerie Ann 
Published: November 2023

AbstractBackgroundThe first few ‘X’ (FFX) studies provide evidence to guide public health decision‐making and resource allocation. The adapted WHO Unity FFX protocol for COVID‐19 was implemented to gain an understanding of the clinical, epidemiological, virological and household transmission dynamics of the first cases of COVID‐19 infection detected in Juba, South Sudan.MethodsLaboratory‐confirmed COVID‐19 cases were identified through the national surveillance system, and an initial visit was conducted with eligible cases to identify all close contacts. Consenting cases and close contacts were enrolled between June 2020 and December 2020. Demographic, clinical information and biological samples were taken at enrollment and 14–21 days post‐enrollment for all participants.ResultsTwenty‐nine primary cases and 82 contacts were included in the analyses. Most primary cases (n = 23/29, 79.3%) and contacts (n = 61/82, 74.4%) were male. Many primary cases (n = 18/29, 62.1%) and contacts (n = 51/82, 62.2%) were seropositive for SARS‐CoV‐2 at baseline. The secondary attack rate among susceptible contacts was 12.9% (4/31; 95% CI: 4.9%–29.7%). All secondary cases and most (72%) primary cases were asymptomatic. Reported symptoms included coughing (n = 6/29, 20.7%), fever or history of fever (n = 4/29, 13.8%), headache (n = 3/29, 10.3%) and shortness of breath (n = 3/29, 10.3%). Of 38 cases, two were hospitalised (5.3%) and one died (2.6%).ConclusionsThese findings were used to develop the South Sudanese Ministry of Health surveillance and contract tracing protocols, informing local COVID‐19 case definitions, follow‐up protocols and data management systems. This investigation demonstrates that rapid FFX implementation is critical in understanding the emerging disease and informing response priorities.
Citalopram‐induced Photopigmentation
Authors: I˚nalöz H. Serhat , Kirtak Necmettin , Herken Hasan , Özgöztaşi Orhan , Aynacioğlu A. Şükrü 
Published: November 2023

AbstractCitalopram is one of the newer and most potent selective serotonin re‐uptake inhibitor (SSRI) drugs. It has a well‐established antidepressive action with a favorable adverse event profile. We present a fifty‐year‐old woman with diffuse photopigmentation who had been diagnosed as suffering from depression. The patient was given citalopram (40 mg/day) for her psychiatric condition and diffuse photopigmentation was noted thereafter. To our knowledge, such an adverse event has not been reported previously.
CD56‐Positive Cutaneous Lymphoma with Multicentric Castleman's Disease‐like Systemic Manifestations
Authors: Amo Yasuyuki , Ogata Fuyuki , Okabe Seigo , Yonemoto Kohzoh , Katsuoka Kensei 
Published: November 2023

AbstractWe report a 55‐year‐old Japanese male with CD56+ cutaneous lymphoma. The patient had multiple cervical lymphadenopathy, a red nodule on his neck, and parotid gland nodularity. Histologic features of the biopsied cervical lymph node showed follicular hyperplasia with numerous plasma cells. A biopsied skin specimen of the nodule on his neck demonstrated dense infiltration of atypical large lymphocytes into the dermis. Immunohistochemical study of this specimen revealed CD3+, CD4+, and CD56+ expression in the majority of neoplastic cells. Polymerase chain reaction assays for the detection of Epstein‐Barr virus sequences were positive for lymph node and skin DNA. Laboratory examinations showed polyclonal gammopathy, pancytopenia, and high serum interleukin‐6 levels. These clinical and histological findings resembled those of multicentric Castleman's disease.
A Case of Proliferative Fasciitis in the Abdominal Region
Authors: Honda Yoshihide , Oh‐i Tsunao , Koga Michiyuki , Serizawa Hiromi 
Published: November 2023

AbstractA 20‐year‐old woman complained of a subcutaneous nodule accompanied by spontaneous pain and tenderness in the right hypochondriac region approximately two weeks prior to initial evaluation. The spontaneous pain and tenderness gradually worsened. Histopathological examination revealed a proliferative lesion that extended from the deep dermis to the fatty tissue and consisted predominantly of stellate or spindle‐shaped fibroblast‐like cells intermingled with gangliocyte‐like giant cells. Consequently, proliferative fasciitis was diagnosed. Our investigation revealed only 19 cases of proliferative fasciitis reported in Japan. The overall age range of them is 20 to 75 years (mean, 57.6 years). The lesion site in them is the head and neck in 10%, the trunk in 30%, and the extremities in 60%. It follows that the extremities are predominantly the site of proliferative fasciitis, and truncal lesions are relatively rare. It is rare for proliferative fasciitis to occur at a young age or in the abdominal region. We therefore examined the differences between proliferative fasciitis and similar disorders, namely proliferative myositis and nodular fasciitis, based on summaries of cases reported in Japan.
The Induction of Heme Oxygenase‐1 by Exogenous Nitric Oxide in ex vivo Normal Human Skin
Authors: Shimizu Kazuhiro , Naito Shinji , Urata Yoshishige , Takamiyagi Atsushi , Bae Sang Jae , Ogawa Fumihide , Kondo Takahito , Katayama Ichiro 
Published: November 2023

AbstractGaseous carbon monoxide (CO) has received attention as a neurotransmitter and as a material involved in persistent dilatation of vessels. CO is released by heme oxygenase (HO) during the process from heme to bilirubin or biliverdin. Many reports have revealed that exogenous nitric oxide (NO) can induce HO‐1 in vitro, which is the induced isoform of HO. In the present study, we attempted an ex vivo system as an explant culture. A quantitative analysis was performed in combination with a reverse transcription–competitive polymerase chain reaction method, which proved to be very accurate, as well as a qualitative analysis with an immunohistochemistry. With this system we confirmed the induction of HO–1 mRNA and protein by exogenous NO in normal human skin. Our results concluded that this ex vivo system was very useful, because skin samples could be handled easily under conditions close to the in vivo situation.
Relative Frequency of the Different Types of Cutaneous T Cell and Natural Killer Cell Lymphomas in Korea Based on the Proposed WHO Classification and the EORTC Classification
Authors: Chang Sung‐Eun , Jee Min‐Sun , Kim Kyoung Jin , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: November 2023

AbstractThe R.E.A.L. classification was largely adopted recently by the proposed WHO classification. The usefulness of this classification in cutaneous T cell and natural killer (NK) cell lymphomas in Korea was evaluated compared to that of the European Organization for Research and Treatment of Cancer (EORTC) classification. Overall, 78 patients with cutaneous T cell and NK cell lymphomas were diagnosed in Asan Medical Center in the 1990's. The clinical records, slides of H&E and immunohistochemical stainings were reviewed. By the proposed WHO classification, mycosis fungoides (20 cases), lymphomatoid papulosis (13 cases), nasal type NK/T‐cell lymphoma (10 cases), CD30+ anaplastic large cell lymphoma (8 cases), subcutaneous panniculitis‐like T‐cell lymphoma (6 cases), peripheral T‐cell lymphoma, unspecified (3 cases), Sézary syndrome (1 case) and blastic NK cell lymphoma (1 case) comprised the primary cases. Secondary or undetermined cases included peripheral T‐cell lymphoma, unspecified (10 cases), nasal type NK/T‐cell lymphoma (5 cases), and angioimmunoblastic T‐cell lymphoma (1 case). EORTC classification for cutaneous T cell and NK cell lymphomas did not include nasal and nasal type NK/T‐cell lymphomas, unspecified non‐pleomorphic T‐cell lymphoma, undetermined cases among primary or secondary ones and some rare types of skin lymphomas which can be classified by WHO. The WHO classification is more useful for skin lymphomas in Korea since it encompassed all the various types of skin T cell and NK cell lymphomas in Korea.
Stevens‐Johnson Syndrome with Idiopathic Thrombocytopenic Purpura Treated with Dexamethasone Pulse Therapy
Authors: Barman Krishna Deb , Verma Kaushal K. , Agrawal Sudha , Agarwalla Arun , Rijal Arpana 
Published: November 2023

AbstractStevens‐Johnson syndrome (SJS) is a severe, episodic, acute, mucocutaneous hypersensitivity reaction often caused by drugs. We herewith report a case of SJS with idiopathic thrombocytopenic purpura (ITP) that did not respond to daily oral prednisolone therapy. When treated with dexamethasone pulse therapy, the response was found to be very good. Therefore, we concluded that dexamethasone pulse therapy can be a good and an effective alternative therapy for treatment of such patients. However, to establish its role, further trials in more patients are needed.
A Case of Baboon Syndrome Associated with Group A Streptococcal Infection
Authors: Ichimiya Makoto , Hamamoto Yoshiaki , Muto Masahiko 
Published: November 2023

AbstractWe described a 21‐year‐old Japanese patient with sore throat, fever, and diffuse erythema on the neck, trunk, and limbs. Erythema markedly appeared on the neck, axillary, antecubital, and popliteal fossae. However, other skin signs of scarlet fever such as red strawberry tongue and linear petechial eruption did not appear. Before his visit to our clinic, he had been diagnosed as pharyngitis and treated with cefaclor 750 mg daily for six days. However, the symptoms did not improve. Oral prednisolone of 20 mg daily rapidly improved all the symptoms. Pharyngeal culture grew Streptococcus pyogenes that was sensitive to cefaclor. Laboratory findings showed elevated serum levels of antibody against streptolysin O. Together with the distribution of erythema, culture of Streptococcal pyogenes, and elevated anti‐streptolysin O titer, the diagnosis of baboon syndrome associated with streptococcal infection was made. This seems to be the first report of baboon syndrome due to streptococcal infection.
The perspectives of internationally qualified nurses regarding their specialty skill transition to Australia: A cross‐sectional survey
Authors: Kurup Chanchal , Burston Adam Scott , Betihavas Vasiliki , Jacob Elisabeth Ruth 
Published: November 2023

AbstractAimTo identify barriers and facilitators of speciality skill transfer for internationally qualified nurses in Australia from the nurses' perspective.DesignA cross‐sectional study.MethodsA cross‐sectional online survey was distributed through social media, snowballing and nursing professional organization. Data analysed using Statistical Package for the Social Sciences.Data SourcesOnline survey data from participants matching the inclusion criteria were collected from July to September 2022.ResultsSurvey results reveal facilitators (competence, scope of practice, linguistic sufficiency, understanding of decision‐making) and barriers (lack of opportunity, transition pathways, confidence in overseas education, financial instability) for internationally qualified nurses' speciality skill utilization in Australia.ConclusionIdentifying and addressing barriers and facilitators, along with developing tailored transition pathways, are crucial for maximizing speciality skill utilization among internationally qualified nurses. These findings have implications for policymakers, healthcare organizations and nurses. They highlight the need to address barriers, facilitate smooth transitions and implement proactive measures for internationally qualified nurses to effectively utilize their specialty skills.ImpactThe study addresses maximizing skill usage for internationally qualified nurses, identifies barriers and facilitators for specialty skill transfer in Australia and will impact policymakers, healthcare organizations and nurses by guiding strategies for safe nursing service delivery and optimizing patient care.Reporting MethodSTROBE checklist.Patient or Public ContributionA total of 71 internationally qualified nurses contributed their experiences and opinions.What Does this Paper Contribute to the Wider Global Clinical Community?

Lack of opportunity and the lack of transition pathways inhibit the use of specialty nursing skills by internationally qualified nurses.

This study's findings contradict the result of other studies that suggest language is a significant obstacle to the utilization of specialty skills of internationally qualified nurses.

Trial and Protocol RegistrationThe protocol is registered on OSF. The data for this study are available for sharing with the reviewers upon request. However, it is worth noting that ethical approval has not been obtained specifically for web sharing, and therefore, the data has not been posted in any repositories or public platforms.
Women's experiences of online antenatal education: An integrative literature review
Authors: Whitworth Kassie , Donnellan‐Fernandez Roslyn , Fleet Julie‐Anne 
Published: November 2023

AbstractAimTo identify what is currently known about how women experience online antenatal education.DesignIntegrative literature review.Review MethodsThis integrative review applied the five‐stage methodological framework outlined by Whittemore and Knafl (2005), supporting rigour in problem identification, selection and critical appraisal of quality literature, data analysis and synthesis of findings.Data SourcesA literature search was conducted in May/June 2022, utilizing databases including OVID Embase, CINAHL, Joanna Briggs Institute EBP database, Nursing and Allied Health database, Wiley Online Library, Google scholar search engine and related reference lists. The search was limited to English language and primary research articles published in the last 10‐year period (2012–2022).Results12 articles met inclusion criteria. Three primary themes were identified: Comprehensibility: Looking back – understanding women's needs and preferences; Manageability: In the moment – flexibility versus social connection; and Meaningfulness & sustainability: Looking forward – the future of digital maternity education.ConclusionFindings identified a marked digital divide for women accessing online antenatal education, placing vulnerable women at risk of continuing inequity. E‐health literacy frameworks need to be implemented to create genuine accessibility, comprehensibility and cultural responsiveness to best meet the needs of users.Implications for the Profession and/or Health Care ConsumerAs digital health is an emerging field, there is strong evidence that online antenatal education requires further evaluation to better meet the needs of pregnant women and their support people. Enhancing digital health literacy for health professionals will also promote a greater understanding for how to uphold and support the socio‐technical dimensions of online service delivery.Patient or Public ContributionThere were no patient or public contributions as part of this integrative review of the literature.
Convergent evolution of the environmental adaptability of high‐elevation populations of waist‐shaped bugs
Authors: Wang Shujing , Li Yanfei , Zhou Jiayue , Chen Juhong , Jiang Kun , Ye Zhen , Xue Huaijun , Bu Wenjun 
Published: November 2023

AbstractAimSimilar environmental selection pressures drive the occurrence of convergent evolution among species. However, studies on this phenomenon are scarce at the population level. Here, we used two waist‐shaped bugs to test the hypothesis that similar high‐elevation habitat environments could lead to similar genetic adaptations among populations of different species.LocationEast Asia.TaxaMalcus sinicus Štys, 1967 & Malcus insularis Štys, 1967.MethodsPopulation genetic structure was determined by phylogenetic and phylogeographical analyses. Demographic history was inferred by comparing simulated history models. Suitable habitat from the last interglacial period (LIG) to the present was predicted by ecological niche modelling (ENM). Convergent evolutionary processes were jointly assessed by the comparison of population ecological differences and the principal component analysis of environmentally related single‐nucleotide polymorphisms (SNPs).ResultsOur results showed that the land bridge in the Pleistocene helped ancestral populations of M. sinicus and M. insularis diffuse from mainland China to Taiwan Island. Subsequently, the geographical barrier imposed by the Taiwan Strait promoted the species differentiation. Geographic isolation and adaptive evolution jointly promoted the population differentiation in M. sinicus. Genetic similarity was found between the populations of M. sinicus in southwestern China (sin‐YN) and M. insularis on Taiwan Island (ins‐TW). Temperature‐related environmental factors and elevation were found to similarly and significantly clustered with ins‐TW and sin‐YN and were clearly distinguished from the other low−/mid‐elevation populations of M. sinicus (sin‐EA). Furthermore, the SNPs related to these environmental factors presented the same clustering results.Main ConclusionsOur study revealed a novel disjunct distribution pattern between southwestern China and Taiwan Island at the population level and provided evidence of convergent evolution of local populations in high‐elevation environments. Here, we revealed that similar environmental selection pressures can drive the occurrence of convergent evolution at the population level among different species.