bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exact separation of the rounded capacity inequalities for the capacitated vehicle routing problem
Authors: Pavlikov Konstantin , Petersen Niels Christian , Sørensen Jon Lilholt 
Published: September 2023

AbstractThe family of Rounded Capacity (RC) inequalities is one of the most important sets of valid inequalities for the Capacitated Vehicle Routing Problem (CVRP). This paper considers the problem of separation of violated RC inequalities and develops an exact procedure employing mixed integer linear programming. The developed routine is demonstrated to be very efficient for small and medium‐sized problem instances. For larger‐scale problem instances, an iterative approach for exact separation of RC inequalities is developed, based upon a selective variable pricing strategy. The approach combines column and row generation and allows us to introduce variables only when they are needed, which is essential when dealing with large‐scale problem instances. A computational study demonstrates scalability of the proposed separation routines and provides exact RC‐based lower bounds to some of the publicly available unsolved CVRP instances. The same computational study provides RC‐based lower bounds for very large‐scale CVRP instances with more than 3000 locations obtained within appropriate computational time limits.
A semi‐hybrid‐mixed method for Stokes–Brinkman–Darcy flows with H(div)‐velocity fields
Authors: Carvalho Pablo G. S. , Devloo Philippe R.B. , Gomes Sônia M. 
Published: October 2023

SummaryWe consider new semi‐hybrid‐mixed finite element formulations for Stokes–Brinkman problems. Using ‐conforming approximate velocity fields, the continuity of normal components over element interfaces is taken for granted, and pressure is searched in discontinuous spaces preserving the divergence compatibility property. Tangential continuity is weakly imposed by a Lagrange multiplier playing the role of tangential traction. The method is strongly mass‐conservative, leading to exact divergence‐free simulations of incompressible flows. The Lagrange multiplier space requires specific choices according to the velocity approximations implemented in each element geometry. In certain cases, classic divergence‐compatible pairs adopted for Darcy flows may require divergence‐free bubble enrichment to enforce tangential continuity in some extent, avoiding any extra stabilization technique. Considerable improvement in computational performance is achieved by the application of static condensation: the global system is solved only for a piecewise constant pressure variable, velocity normal trace and tangential traction over interfaces. The remaining solution components are recovered by solving independent local Neumann problems in each element. Numerical results are presented for a set of standard test cases in the field of Stokes–Brinkman–Darcy flows with known analytical solutions. The main convergence properties of the method are verified in the whole range of parameters, from Stokes to Darcy limits, as well as for the combined Stokes–Darcy scenario. The robustness of the method is also demonstrated for more challenging test problems with complex non‐conforming meshes with local refinement patterns as well as for curved geometry.
Predictors of Quality of Life for Head and Neck Cancer Patients at an Academic Institution
Authors: Lorenz F. Jeffrey , King Tonya S. , Engle Linda , Beauchamp‐Perez Francis , Goyal Neerav 
Published: October 2023

AbstractObjectiveQuality of life (QOL) is an important consideration in head and neck cancer (HNC) due to lasting disease and treatment‐related toxicities. We performed a comprehensive review of predictors of QOL in this population, including distance to care.Study DesignRetrospective cohort study from 2017 to 2022.SettingAcademic medical center.MethodsQOL was quantified in patients treated for HNC utilizing the University of Washington Quality of Life and 20‐Item Short Form surveys completed at subsequent clinic visits. Distance to treatment center and other demographic, socioeconomic, disease‐specific, and behavioral data were analyzed.ResultsThere were 176 patients in the cohort (69% male; mean age, 64 ± 10.8 years). There was no association between miles traveled and any of the QOL subscales. Marital status was the strongest predictor of QOL, significantly associated with 7/8 QOL domains and favoring those who were married. Other significant predictors of decreased QOL included emotional/physical abuse, current tobacco use, documented religious affiliation, and treatment involving surgery plus adjuvant therapy. A significant positive trend over time existed for multiple QOL subscales.ConclusionQOL is unchanged in patients who travel greater distances for care. QOL is more closely linked to factors such as marital status, physical/emotional abuse, tobacco use, religious affiliation, treatment intensity, and time following surgery. This highlights the importance of a strong support structure and the influence of certain socioeconomic and lifestyle factors on patients, with opportunities for screening and intervention throughout their cancer care.
Prostatic proliferative inflammatory atrophy: welcome to the club†
Authors: Bernard Matthew J , Smith Chad M , Goldstein Andrew S 
Published: September 2023

AbstractSingle‐cell RNA sequencing studies in the human prostate have defined a population of epithelial cells with transcriptional similarities to club cells in the lung. However, the localization of club‐like cells in the human prostate, and their relationship to prostate cancer, is poorly understood. In a new article in The Journal of Pathology, RNA in situ hybridization was used to demonstrate that club cell markers are expressed in luminal cells adjacent to inflammation in the peripheral zone of the human prostate, where prostate cancer tends to arise. These club‐like cells are commonly found in proliferative inflammatory atrophy (PIA) lesions and express markers consistent with an intermediate epithelial cell‐type. Future studies will be needed to understand the functional role of club‐like cells in human prostate inflammation, regeneration, and disease. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Cosmic Evolution of Five‐dimensional Einstein Chern‐Simons Gravity Through Dark Energy Model
Authors: Jawad Abdul , Kiran Fareeha , Rani Shamaila 
Published: September 2023

AbstractIn this paper, the cosmic evolution in the context of five‐dimensional Einstein Chern‐Simons gravity theory by using flat homogeneous and isotropic universe model is studied. The interaction is taken into account between dark sector of the evolving universe along with holographic dark energy model with Hubble horizon. Our study with well‐known models EChS ‐β5 and EChS ‐ for Einstein Chern‐Simons gravity theory in five dimensions are carried. Some cosmological parameters through graphical representations such as coincidence parameter u, equation of state parameter , deceleration parameter q and squared speed of sound parameter is analyzed. It is found that these cosmological parameters show consistent behavior with current cosmic scenario. Also, the behavior of generalized second law of thermodynamics in the underlying gravity theory with Bekenstein‐Hawking entropy and its validity for some fixed values of constants appearing in each model are explored.
Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects
Authors: Singh Deepti , Khan Mohammad Afsar , Siddique Hifzur R. 
Published: September 2023

AbstractDrug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds, biological agents, and medical products. These reactions can manifest as acute or chronic damage to the liver. From 1997 to 2016, eight drugs, including troglitazone, nefazodone, and lumiracoxib, were removed from the market due to their liver‐damaging effects, which can cause diseases. We aimed to review the recent research on natural products and their bioactive components as hepatoprotective agents in mitigating DILI. Recent articles were fetched via searching the PubMed, PMC, Google Scholar, and Web of Science electronic databases from 2010 to January 2023 using relevant keywords such as “natural products,” “acetaminophen,” “antibiotics,” “paracetamol,” “DILI,” “hepatoprotective,” “drug‐induced liver injury,” “liver failure,” and “mitigation.” The studies reveal that the antituberculosis drug (acetaminophen) is the most frequent cause of DILI, and natural products have been largely explored in alleviating acetaminophen‐induced liver injury. They exert significant hepatoprotective effects by preventing mitochondrial dysfunction and inflammation, inhibiting oxidative/nitrative stress, and macromolecular damage. Due to the bioavailability and dietary nature, using natural products alone or as an adjuvant with existing drugs is promising. To advance DILI management, it is crucial to conduct well‐designed randomized clinical trials to evaluate natural products' efficacy and develop new molecules clinically. However, natural products are a promising solution for remedying drug‐induced hepatotoxicity and lowering the risk of DILI.
Effect of resveratrol and curcumin and the potential synergism on hypertension: A mini‐review of human and animal model studies
Authors: Ghaeini Hesarooeyeh Zahra , Basham Ayoub , Sheybani‐Arani MohammadHosein , Abbaszadeh Mahshid , Salimi Asl Ali , Moghbeli Meysam , Saburi Ehsan 
Published: October 2023

AbstractResveratrol (RES) and curcumin (CUR) are two of the most extensively studied bioactive compounds in cardiovascular research from the past until today. These compounds have effectively lowered blood pressure by downregulating the renin‐angiotensin system, exerting antioxidant effects, and exhibiting antiproliferative activities on blood vessels. This study aims to summarize the results of human and animal studies investigating the effects of CUR, RES, and their combination on hypertension and the molecular mechanisms involved. The published trials' results are controversial regarding blood pressure reduction with different doses of RES and CUR, highlighting the need to address this issue.
A comprehensive analysis of electronic transitions in naphthalene and perylene diimide derivatives through computational methods
Authors: Hussain Wajid , Iqbal Muhammad Shahid , Li Hui , Sulaman Muhammad , Guo Honglian , Li Chuanbo , Sandali Yahya , Irfan Ahmad , Ali Hafiz Saqib 
Published: October 2023

AbstractPerylene diimide (PDI) and naphthalene diimides (NDIs) are compounds widely used in supramolecular structures due to their versatile and functional properties. They have high absorptions and photoluminescence capabilities, which make them ideal for electronic transition studies. Reflux method, a widely employed synthetic technique, was utilized to synthesize NDI and PDI derivatives. In this method, the respective amino acids and NTDA (naphthalene‐1,4,5,8‐tetracarboxylic dianhydride) were combined in acetic acid and the resulting mixture was subjected to reflux. This study centered on a diverse set of NDI and PDI ligands, comprising L‐ala‐NDI, B‐ala‐NDI, Gly‐NDI, Imi‐NDI, Pyr‐NDI, L‐ala‐PDI, B‐ala‐PDI, Gly‐PDI, Imi‐PDI, and Pyr‐PDI ligands. Crystal structures were obtained for three NDI ligands, while the characterization of all ligands involved several analytical techniques such as NMR, IR, UV, DFT, TD‐DFT calculations, and single‐crystal x‐ray crystallography specifically for the NDI ligands. The investigation focused on studying the electron acceptor/donor behavior of the NDI and PDI ligands, identifying their potential for charge transfer applications. Furthermore, the NLO (nonlinear optical) response of all 10 NDI and PDI ligands was assessed through an analysis involving HOMO‐LUMO, TDM, EDDM, NCI, Iso‐surface, MEP, natural population, and DOS analysis. This evaluation encompassed the examination of linear polarizability, as well as first and second hyperpolarizability in the context of NLO. The findings of the study revealed that Gly‐PDI, Imi‐PDI, L‐ala‐PDI, and B‐ala‐PDI ligands displayed a higher NLO response compared with the other ligands. These results highlight the potential of these ligands for nonlinear optical applications. The comprehensive characterization and assessment of the NDI and PDI ligands contribute to a deeper understanding of their electron properties, positioning them as promising candidates for charge transfer and nonlinear optical materials.
Cost‐effectiveness of a novel, fluoroscopy‐based robotic‐assisted total hip arthroplasty system: A Markov analysis
Authors: Ong Christian B. , Buchan Graham B. J. , Acuña Alexander J. , Hecht Christian J. , Homma Yasuhiro , Shah Roshan P. , Kamath Atul F. 
Published: September 2023

AbstractBackgroundThe purpose of this study was to assess the cost‐effectiveness of a novel, fluoroscopy‐based robotic‐assisted total hip arthroplasty (RA‐THA) system compared to a manual unassisted technique (mTHA) up to 5 years post‐operatively.MethodsA Markov model was constructed to compare the cost‐effectiveness of RA‐THA and mTHA. Cost‐effectiveness was defined as an Incremental Cost‐Effectiveness Ratio (ICER) <$50 000 or $100 000 per Quality Adjusted Life Year (QALY).ResultsRA‐THA patients experienced lower costs compared to mTHA patients at 1 year ($20 865.12 ± 9897.52 vs. $21 660.86 ± 9909.15; p < 0.001) and 5 years ($23 124.57 ± 10 045.48 vs. $25 756.42 ± 10 091.84; p < 0.001) post‐operatively. RA‐THA patients also accrued more QALYs (1‐year: 0.901 ± 0.117 vs. 0.888 ± 0.114; p < 0.001; 5‐years: 4.455 ± 0.563 vs. 4.384 ± 0.537 p < 0.001). Overall, RA‐THA was cost‐effective (1‐year ICER: $−61 210.77; 5‐year ICER: $−37 068.31).ConclusionsThe novel, fluoroscopy‐based RA‐THA system demonstrated cost‐effectiveness when compared to manual unassisted THA.
Adaptive dynamic output feedback FTC for nonlinear systems with unknown nonlinearities and faults
Authors: Gong Cui‐Mei , Huang Sheng‐Juan 
Published: September 2023

AbstractThe problem of adaptive dynamic output feedback fault tolerant control (FTC) for a class of nonlinear systems with unknown nonlinearities and faults is investigated, in which the nonlinearities do not need to satisfy the Lipschitz condition, so the system can represent a wider range of nonlinear system models. An adaptive dynamic output feedback FTC is designed, where the output and its derivatives are fully applied to compensate the actuator faults on systems. The designed control method can effectively offset the effect of faults on systems so as to stabilized the nonlinear system. Furthermore, based on the designed controller, the coupling term can be eliminated reasonably and less conservative stability conditions for the closed‐loop system have been obtained. The proposed control strategy pledges that the states of the closed‐loop system are uniformly ultimately bounded (UUB). Two numerical examples are presented to exhibit the effectiveness and merits of the proposed control scheme.
Soil carbon increase from crop roots and amendments still present twelve years later
Authors: Wuest Stewart B. 
Published: September 2023

AbstractSoil organic carbon was measured after surface application of equal C amounts from various C sources to fallow soil or a winter wheat crop for five consecutive years. Municipal biosolid produced the largest gain, followed by manure and alfalfa (Medicago sativa L.) foliage. Wheat (Triticum aestivum L.) straw, sucrose, and wood sawdust were not different than no addition. These effects were additive to and independent from the effect of fallow soil versus cropped soil. Soil cropped to winter wheat increased in C comparable to the biosolid application or to plots planted to perennial grass. Measurements 4, 6, and 12 years after a return to normal farming practices produced no change in relative or quantitative differences. These results illuminate the durability of above‐ and below‐ground contributions to soil C.
Oxygen‐Vacancy‐Reinforced Vanadium Oxide/Graphene Heterojunction for Accelerated Zinc Storage with Long Life Span
Authors: Zheng Chen , Huang Zi‐Hang , Sun Fang‐Fang , Zhang Yue , Li Hui , Liu Yong , Ma Tianyi 
Published: September 2023

AbstractVanadium trioxide (V6O13) cathode has recently aroused intensive interest for aqueous zinc‐ion batteries (AZIBs) due to their structural and electrochemical diversities. However, it undergoes sluggish reaction kinetics and significant capacity decay during prolonged cycling. Herein, an oxygen‐vacancy‐reinforced heterojunction in V6O13−x/reduced graphene oxide (rGO) cathode is designed through electrostatic assembly and annealing strategy. The abundant oxygen vacancies existing in V6O13−x weaken the electrostatic attraction with the inserted Zn2+; the external electric field constructed by the heterointerfaces between V6O13−x and rGO provides additional built‐in driving force for Zn2+ migration; the oxygen‐vacancy‐enriched V6O13−x highly dispersed on rGO fabricates the interconnected conductive network, which achieves rapid Zn2+ migration from heterointerfaces to lattice. Consequently, the obtained 2D heterostructure exhibits a remarkable capacity of 424.5 mAh g−1 at 0.1 A g−1, and a stable capacity retention (96% after 5800 cycles) at the fast discharge rate of 10 A g−1. Besides, a flexible pouch‐type AZIB with real‐life practicability is fabricated, which can successfully power commercial products, and maintain stable zinc‐ion storage performances even under bending, heavy strikes, and pressure condition. A series of quantitative investigation of pouch batteries demonstrates the possibility of pushing pouch‐type AZIBs to realistic energy storage market.
Enhancing Pollutant Mineralization through Organic–Inorganic Defect‐Transit Dual S‐scheme with a Robust Internal Electric Field
Authors: Chen Runlin , Lou Hongming , Pang Yuxia , Yang Dongjie , Qiu Xueqing 
Published: September 2023

AbstractAchieving superior photomineralization of pollutants relies on a rational design of a dual S‐scheme with a robust internal electric field (IEF). In this study, to tackle the low mineralization rate in type‐II In2O3/In2S3(IO/IS) systems, an organic–inorganic dual S‐scheme In2O3/PDI/In2S3(IO/PDI/IS) nanostructured photocatalyst is synthesized via a method combining solvent‐induced self‐assembly and electrostatic forces. Due to the unique energy band position and strong IEF, the photoinduced defect‐transit dual S‐scheme IO/PDI/IS facilitates the degradation of lignin and antibiotics. Notably, a promising mineralization rate of 80.9% for sodium lignosulfonate (SL) is achieved. The charge transport pathway of IO/PDI/IS are further validated through the analysis of in situ X‐ray photoelectron spectroscopy (in situ XPS), density functional theory calculations, and radical trapping experiments. In‐depth, two possible pathways for the photocatalytic degradation of lignin are proposed based on the intermediates monitored by liquid chromatography‐mass spectrometry (LC‐MS). This study presents a new strategy for the design of organic–inorganic dual S‐scheme photocatalysts with a robust IEF for pollutant degradation.
Nanoparticle Assembly: From Self‐Organization to Controlled Micropatterning for Enhanced Functionalities
Authors: Jambhulkar Sayli , Ravichandran Dharneedar , Zhu Yuxiang , Thippanna Varunkumar , Ramanathan Arunachalam , Patil Dhanush , Fonseca Nathan , Thummalapalli Sri Vaishnavi , Sundaravadivelan Barath , Sun Allen , Xu Weiheng , Yang Sui , Kannan Arunachala Mada , Golan Yuval , Lancaster Jessica , Chen Lei , Joyee Erina B. , Song Kenan 
Published: September 2023

AbstractNanoparticles form long‐range micropatterns via self‐assembly or directed self‐assembly with superior mechanical, electrical, optical, magnetic, chemical, and other functional properties for broad applications, such as structural supports, thermal exchangers, optoelectronics, microelectronics, and robotics. The precisely defined particle assembly at the nanoscale with simultaneously scalable patterning at the microscale is indispensable for enabling functionality and improving the performance of devices. This article provides a comprehensive review of nanoparticle assembly formed primarily via the balance of forces at the nanoscale (e.g., van der Waals, colloidal, capillary, convection, and chemical forces) and nanoparticle‐template interactions (e.g., physical confinement, chemical functionalization, additive layer‐upon‐layer). The review commences with a general overview of nanoparticle self‐assembly, with the state‐of‐the‐art literature review and motivation. It subsequently reviews the recent progress in nanoparticle assembly without the presence of surface templates. Manufacturing techniques for surface template fabrication and their influence on nanoparticle assembly efficiency and effectiveness are then explored. The primary focus is the spatial organization and orientational preference of nanoparticles on non‐templated and pre‐templated surfaces in a controlled manner. Moreover, the article discusses broad applications of micropatterned surfaces, encompassing various fields. Finally, the review concludes with a summary of manufacturing methods, their limitations, and future trends in nanoparticle assembly.
Effect of e‐waste materials as filler in the flax woven fiber reinforced polymer composite for a sustainable environment
Authors: Raj J. Immanuel Durai , Durairaj R. B. , Ananth S. Vijay , Meenakshisundaram Nagaraj 
Published: September 2023

AbstractThe main aim of the present investigation is to fabricate waste printed circuit board (WPCB) particles and woven bidirectional flax fiber mat reinforced polymer matrix composite through a hand layup technique followed by vacuum bagging technique and examine its mechanical properties using the Universal Testing Machine (UTM), compression testing machine, and Shore D hardness tester. The WPCB particles with weight percentages of 0, 5, 10, 15, and 20 were used as reinforcement along with five layers of flax fiber mat to improve the adhesion behavior of epoxy resin with reinforcements and thereby improve the properties. The XRF (X‐ray fluorescence) investigation of the prepared WPCB particles confirmed the existence of various toxic elements in the processed printed circuit board (PCB). The scanning electron microscopy (SEM) analysis confirmed the presence of WPCB particles in the composite, along with flax fiber and resin. The tensile, compression, impact test shows that that the 15 wt.% WPCB particles reinforced flax fiber polymer composite gave betters properties, and the reduction of properties was seen thereafter. The percentage of water absorption increased with the weight percentage of the WPCB particles from 0% to 20%. Results indicate that the biodegradable flax fiber composites impregnated with WPCB filler can be utilized for many engineering and domestic applications.