bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structured-Unstructured Activity Behaviours on Young Children's Mental and Physical Health: A Compositional and Isotemporal Reallocation Analysis
Authors: Delong CHEN , Guanggao ZHAO , Jinmei FU , Sunli SHUN , Liqiang SU , Zihao HE , Ruiming CHEN , Tianle JIANG , Xuewen HU , Yunong Li , Fanchao Shen 
Published: January 2024

Abstract

Objective
This study aimed to investigate the effects of time reallocation between structured and unstructured activities on young children's mental and physical health.
Methods
324 children aged 3–6 years who volunteered to participate. Video observation combined with the System for Observing Play and Recreation in Communities (SOPARC) is used to classify structured and unstructured activity types. An accelerometer sensor ActiGraph GT3X-BT worn on the right iliac was used to measure activity intensity. The mental indicators of young children were collected using the Strengths and Difficulties Questionnaire (SDQ) and physical indicators such as Physical Shape and Physical Fitness were measured. The component data and isotemporal substitution analyses were also conducted with the help of R Studio (Version 4.2).
Results
Internalizing difficulties were significantly improved in young children using 10-minute structured moderate to vigorous physical activity (MVPA) or unstructured MVPA isotemporal substitution structured low-intensity physical activity (LPA), sedentary behaviour, with the effectiveness increasing as the substitution time lengthens. and the effect size increases with substitution time. physical shape was significantly improved in young children using 10-minute structured MVPA isotemporal substitution.
Conclusion
Increasing structured MVPA can improve young children's emotional symptoms and physical morphology, and increasing the proportion of MVPA in structured activities has higher health benefits.
A 78-year-old male with Rasagiline-Induced Pseudopheochromocytoma: The first Case Report from Syria
Authors: Almohamed Ahmad , Sleiay Mouhammed , Haydar Hasan , Almhamad Ebrahim , Hamsho Suaad , Kazkz Waddah 
Published: January 2024

Abstract

Background: Pseudopheochromocytoma is a clinical disorder characterized by severe paroxysmal vasoconstriction and normal or mildly to moderately elevated levels of catecholamines and metanephrine, without any evidence of a tumorous origin. Because the adrenergic system is activated, the patients have severe paroxysmal hypertension along with headache, palpitations, and diaphoresis. Rasagiline-induced pseudopheochromocytoma is very rare. Our case report is the first one worldwide manifesting with this medication.
Case presentation: The patient, a 78-year-old man with Parkinson's disease, started exhibiting symptoms of paroxysmal high blood pressure that did not decrease despite taking antihypertensive medications. An endocrine evaluation confirmed significantly elevated levels of urine dopamine and homovanillic acid, as well as plasma dopamine, with high levels of urine normetanephrine. Fludeoxyglucose scintigraphy ruled out the presence of a pheochromocytoma localized in the adrenals, migratory, or metastatic. A PET scan revealed no abnormalities. The Rasagiline treatment was stopped for eight days and was replaced with 200mg of amantadine every day. Two weeks after the discontinuation, we noticed a normalization of the elevated urinary and plasma dopamine levels as well as the increased urinary homovanil.
Conclusions: Pseudopheochromocytoma may be related to Rasagiline alone or in conjunction with other drugs that have a tendency to inhibit catecholamine or dopamine metabolism.
Sentiment Analysis of Video Danmakus Based on MIBE-RoBERTa-FF-BiLSTM
Authors: Zhao Jianbo , Liu Huailiang , Wang Yakai , Zhang Weili , Zhang Xiaojin , Li Bowei , Sun Tong , Qi Yanwei , Zhang Shanzhuang 
Published: January 2024

Abstract
Danmakus are user-generated comments that overlay on videos, enabling real-time interactions between viewers and video content. The emotional orientation of danmakus can reflect the attitudes and opinions of viewers on video segments, which can help video platforms optimize video content recommendation and evaluate users’ abnormal emotion levels. Aiming at the problems of low transferability of traditional sentiment analysis methods in the danmaku domain, low accuracy of danmaku text segmentation, poor consistency of sentiment annotation, and insufficient semantic feature extraction, this paper proposes a video danmaku sentiment analysis method based on MIBE-RoBERTa-FF-BiLSTM. This paper constructs a "Bilibili Must-Watch List and Top Video Danmaku Sentiment Dataset” by ourselves, covering 10,000 positive and negative sentiment danmaku texts of 18 themes. A new word recognition algorithm based on mutual information (MI) and branch entropy (BE) is used to discover 2,610 irregular network popular new words from trigrams to heptagrams in the dataset, forming a domain lexicon. The Maslow’s hierarchy of needs theory is applied to guide the consistent sentiment annotation. The domain lexicon is integrated into the feature fusion layer of the RoBERTa-FF-BiLSTM model to fully learn the semantic features of word information, character information, and context information of danmaku texts and perform sentiment classification. Comparative experiments on the dataset show that the model proposed in this paper has the best comprehensive performance among the mainstream models for video danmaku text sentiment classification, with an F1 value of 94.06%, and its accuracy and robustness are also better than other models. The limitations of this paper are that the construction of the domain lexicon still requires manual participation and review, the semantic information of danmaku video content and the positive case preference are ignored.
Severe toxic anterior segment syndrome with ocular hypotony: a case report and literature review
Authors: Zhu Yan , Zhou WeiWei , Zhu YuGuang 
Published: January 2024

Abstract

Background To report a rare case of severe toxic anterior segment syndrome with ocular hypotony after uneventful cataract surgery.
Case presentation Toxic anterior segment syndrome (TASS) is an infrequent complication of ocular surgery.Here,we reported a rare TASS case with ocularhypotony after uneventful cataract surgery.A 62-year-old male was presented to our clinic for blurred vision in the right eye.The patient was diagnosed with age-related cataract and the phacoemulsification and intraocular lens implantation was performed uneventfully in the right eye.On the first postoperative day,the diffuse cornea edema and dilated pupil were present in the right eye with a tentative diagnosis of TASS.The medication administration was inffective in the case.The patient developed corneal decompensation 1 year after cataract surgery.Given the resulting corneal edema, the patient underwent Penetrating keratoplasty (PKP),fibrin membrane removal and goniosynechialysis were performed simultaneously.Ocularhypotony developed unexpectedly 2 weeks after PKP and maintained steadily in the case.Ultrasound biomicroscopy (UBM)showed the ciliary body atrophy.Optical coherence tomography (OCT)showed chorioretinal folds caused by hypotony maculopathy after PKP.To the best of our knowledge, we first reported the TASS case with ocularhypotony.
Conclusions In the TASS case,the ocular hypotony was thought to be due to severe atrophy of ciliary body caused by uncertain toxic substance.
Determining The Association of Post-Stroke Epilepsy with The Location of Ischemic Stroke in Adult Patients
Authors: Khan Soban , Waqar Zaid , Iqbal Mansoor , Awan Malik Muhammad Adil , Khalid Bushra , Ali Syed Saad , Khalil Maryam , Saddiqa Amina , Solizay Asmat Ullah Khan 
Published: January 2024

Abstract
BACKGROUND AND OBJECTIVE: Seizures associated to stroke are recurrently encountered by a neurologist. Early post stroke seizures indicate an acute, and possibly recoverable brain damage while late seizures happen because of long-term alteration in brain after stroke. Medical probability models and bio and genetic markers should be combined in near future to aid the identification of progression of post stroke seizures and improve the recognition of post stroke epilepsy in individuals. A study was conducted to assess the role of ischemic stroke as a causative agent for epileptic seizures along the effect of stroke location on seizure severity.
METHODOLOGY: This study is a cross sectional study done over a period of 2 years at neurology department of Pakistan institute of Medical sciences. Study collected the relevant data from 71 patients admitted with ischemic stroke all of whom were monitored for any seizure episode.
RESULTS: Post stroke epilepsy was seen more commonly with ischemic strokes in middle cerebral artery territory. p value came as significant for Pearson Chi-Square and likelihood ratio while p value came as non-significant for linear-by-linear association.
CONCLUSION: As middle cerebral artery came out as hot stop for post stroke seizures, so any survivor of stroke caused due middle cerebral artery should undergo EEG (electroencephalography) which aids in the detection of precise patterns which are related to seizures.
Mood disorders in benign paroxysmal positional vertigo before and after treatment
Authors: Wang Huan , Hong Peiwei , Yan Weidong , Han Lin 
Published: January 2024

Abstract

Aim
Benign paroxysmal positional vertigo (BPPV) is associated with mood disorders. This study aimed to assess changes in anxiety, distress, and sleep in patients with BPPV before and after treatment.
Methods
Changes in mood disorders in patients with BPPV before and after treatment were evaluated with the dizziness handicap inventory (DHI), the Berg balance scale (BBS), the Hamilton Anxiety Rating Scale (HAMA), the Subjective Units of Distress Scale (anxiety level rating) (SUDS) and the Pittsburgh Sleep Quality Index (PSQI) questionnaires. Multiple-linear regression analysis was used to analyze factors influencing dizziness in patients with BPPV.
Results
After treatment, dizziness and mood disorders were alleviated (P < .001), and balance and sleep improved (P < .001). However, their symptoms were worse than the patients’ healthy family members who were the controls (P < .001). Multiple-linear regression analysis showed that BBS, HAMA, and SUDS influenced DHI in BPPV (r2 = 0.66, P < .001).
Conclusions
This study identified variables that influenced BPPV, demonstrating that anxiety, distress, and impaired balance acted as independent predictors for BPPV.
Qingjie Fuzheng Granules treat ulcerative colitis via regulating Th17/Treg cell balance
Authors: zhong hangyan , Liu Haiqin , Liu Jinhong , Yan Shuo , Zou Fenglin , Fan Youlong , Chen Xuzheng , Lin Jiumao 
Published: January 2024

Abstract
Objective:
To investigate the anti-inflammatory properties of Qingjie Fuzheng Granules (QFG)in vivo experiments using a DSS-induced ulcerative colitis (UC) model, and to elucidate the mechanism by which QFG alleviates UC by examining the Th17/Treg cell balance.
Methods: The DSS-induced UC mouse model was established, and the mice were administrated with QFG (1 g/kg) or saline by gavage. The general growth of the mice, including body weight, fecal occult blood, and disease activity index (DAI), was observed, and the length of the colon was recorded. HE staining was utilized to examine the pathological injury of the colon tissue. The expression levels of TGF-β, IFN-γ, IDO1, IL-1β, TNF-α, IL-6, IL-17, IL-21, IL-22, IL-25, IL-10 in serum were detected by ELISA or Bio-Plex. The relative mRNA expressions in spleen and colon tissues were detected by RT-qPCR. The protein expressions of RORγt, Foxp3 or IDO1 in spleen and colon were detected by Western Blot or Immunohistochemical.
Results:
QFG demonstrated potential for improving the overall pathological conditions of UC mice induced by DSS, as evidenced by its significant inhibition of colon length shortening and improvement of colon tissue pathology. Additionally, QFG exhibited the ability to decrease the expression of pro-inflammatory cytokines IL-1β, TNF-α, IFN-γ and IL-6, as well as IDO1 expression. Moreover, QFG significantly reduced the expression of Th17-related cytokines (IL-17, IL-21, IL-22, IL-25) and concurrently increased the expression of Treg-related cytokines (IL-10, TGF-β). The expression of transcription factor RORγt was observed to decrease while the transcription factor Foxp3 was observed to increase in colon and spleen.
Conclusion:
QFG has demonstrated the ability to suppress inflammation in mice with DSS-induced UC. This effect is achieved through the inhibition of Th17 cell differentiation, the promotion of Treg cell differentiation, and the maintenance of Th17/Treg cell balance. These actions are mediated by the regulation of transcription factors RORγt and Foxp3. This mechanism may contribute significantly to the observed inhibition of colon inflammation in mice treated with QFG.
Visual Evoked Potential And Contrast Sensitivity Tests In Anisometropic Amblyopia
Authors: Ashraf Eman , Nada Mona M. , Elhadidy Reem , ElSalmawy Dina , Shuaib Asmaa 
Published: January 2024

Abstract
Background
Amblyopia is a disorder of sight in which the brain fails to process inputs from one eye and over time favors the other eye. Refractive amblyopia is caued by anisometropia (difference of a certain degree of myopia, hypermetropia, or astigmatism), or by significant amount of equal refractive error in both eyes. Visual Evoked Potential/Response (VEP/VER) measures the electrical signal generated at the visual cortex in response to visual stimulation. Contrast sensitivity (CS) is the ability of the eye to detect small changes in illumination at targets that do not have clearly defined limits
Objectives
To compare between the amblyopic eye and the fellow eye regarding the VEP and CS in patients with anisometropic amblyopia.
Methods
This is a cross sectional study carried out on 78 patients with anisometropic amblyopia aging 4.5–12 years. All patients presented with monocular amblyopia. Pattern visual evoked potentials and contrast sensitivity tests were carried out for both eyes.
Results
the amblyopic eye showed an increases in P 100 latency and decrease in amplitude compared to the fellow eye. Also the contrast sensitivity test showed decreased values of the amblyopic eye compared to the fellow eye.
Conclusion
VEP and CS tests could be used to assess the prognosis of patients with anisometropic amblyopia.
Asymmetric response of cross-equatorial ocean heat transport to latitudinal thermal forcing in CESM
Authors: Liu Mingjia , Liu Fukai , Luo Yiyong , Lu Jian 
Published: January 2024

Abstract

The response of cross-equatorial ocean heat transport (OHT) to interhemispheric radiative imbalances is investigated using a set of fully coupled experiments with external radiative forcing imposed at different latitudinal bands at the top of the atmosphere. The modeling results reveal a first-order collaborative relationship between the ocean and the atmosphere, both working in tandem to facilitate the cross-equatorial heat transport to offset the imposed energy imbalance. Considerable asymmetry is also found between the responses to the radiative forcing placed at the same latitude, but in opposite hemispheres. This asymmetry is mainly attributed to the different changes in ocean circulation. When the radiative forcing is placed over the Southern Ocean, a buoyancy-driven clockwise cell is created that extends from the Southern Ocean into the tropics in both the Indo-Pacific and Atlantic basins, effectively transporting energy into the northern hemisphere. Conversely, when the radiative forcing is placed over the northern high latitudes, the Atlantic Meridional Overturning Circulation (AMOC) is weakened, leading to anomalous southward energy transport. In addition, our study reveals the reduced effectiveness of tropical forcing relative to higher latitude forcing in generating anomalous cross-equatorial OHT. This reduced effectiveness is due to the cancellation of the overturning cell-induced cross-equatorial OHT anomaly by the contribution of the horizontal gyre.
National Norms for the Obstetric nurses' and Midwives' health education competence, and its Influencing Factors: A Nationwide Cross-sectional Study
Authors: Zou Jingjing , Wu Jingling , Jiang Xiumin 
Published: January 2024

Abstract
Background
Strengthening obstetric nurses' and midwives' health education competence is the investment and guarantee for the population's future health. The purpose of study is to establish national norms for their health education competence, and explore possible influencing factors for providing an uniform criterion identifying levels and weaknesses.
Methods
An online questionnaire with a standard process was used to collect data. Three normative models were constructed, and multiple linear regression analysis analyzed possible influencing factors.
Results
The sample respondents (n = 3027) represented obstetric nurses and midwives nationally. Three health education competency normative norms (mean, percentile and demarcation norm) were constructed separately. Locations, hospital grade, department, marital status, training times and satisfaction with health education training influenced obstetrical nurses' and midwives' health education competence (P༜0.05).
Conclusion
This study constructed the first national standard for assessing obstetric nurses' and midwives' health education competence, providing a scientific reference to evaluate the degree of health education competence directly. These known factors could help clinical and policy managers designate practice improvement measures. In future research, Grade I hospitals should be studied with larger sample sizes, and indicators need to improve to reflect health education's effect better.
The diagnostic efficacy of serum galectin-3 and other markers in papillary thyroid carcinoma
Authors: Zhang Xiaohong , Song Xin , Li Yu , Liu Xiangyi 
Published: January 2024

Abstract
Background Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, representing approximately 85–90% of cases. Galectin-3 (GAL-3) is a well-established histologic marker of thyroid cancer that is not expressed by normal thyroid cells. The potential utility of serum GAL-3 in differentiating benign thyroid tumors from PTC remains to be studied.Methods According to the postoperative pathology results, patients were divided into the PTC group (165 cases) and the benign thyroid tumor group (95 cases). Serum GAL-3 was detected by chemiluminescence immunoassay (CLIA). Additionally, other markers including human epidermal growth factor receptor 2 (HER2), Ki-67, cytokeratin 19 (CK19), thyroid peroxidase (TPO) and CD56 were detected by enzyme-linked immunosorbent assay (ELISA). Serum levels were compared between patients with PTC and those with benign tumors using SPSS 22.0.Results In patients with PTC, serum GAL-3 levels were significantly higher than those in patients with benign thyroid tumors (p = 0.045). Additionally, serum HER-2 and Ki-67 levels in PTC patients were significantly higher than those in patients with benign tumors (p < 0.05) as well. However, there were no significant differences between the two groups in CK19, TPO, and CD56 (p > 0.05). The Receiver Operating Characteristic (ROC) curve analysis revealed that GAL-3 had an area under the curve (AUC) of 0.645 (p = 0.000) for distinguishing between benign and malignant thyroid tumors. When combined with HER2 and Ki-67, the AUC increased to 0.787 (p = 0.000).Conclusions Our research results indicate that the combination of GAL-3, HER2, and Ki-67 can be used to differentiate between benign and malignant thyroid diseases.Trial registration Not applicable
Effect of transport stress on apoptosis and autophagy in goat lung cells
Authors: Zhuo Yu , Hu Yunhai , Liu Ben , Zheng Wenya , Yi Wanting , Yang Xue , Zheng Lucheng , Hu Wei , Jin Yangshan , Ye Tian , Yang Yanzhen 
Published: January 2024

Abstract

Background Goats undergoing road transportation are subjected to inverse organismal disturbances in the external environment, with high temperatures, bumps, and complex microbial environments during transportation linking to compound stressors, which can trigger pathological apoptosis and autophagy. Pathological cell death dysregulating the homeostasis of the internal environment of the organism and thus causing immunosuppression and tissue damage. Bcl-2 and Bax are a pair of functional antagonistic proteins regulating apoptosis, p62, LC3B and the PINK1/Parkin pathway have also been shown to play important mediating roles in the process of cellular autophagy. The aim of this study was to investigate the effects of transportation stress on proteins related to apoptosis and autophagy in goat lung cells. Nine healthy male Ganxi goats were selected and divided into control group without transport (0h transport group), 2h transport group, 6h transport group, three in each group, and the lungs were taken after treatment. Results The results of the study showed that transportation stress increased the apoptosis rate in goat lungs, which was significantly higher in the 2h transportation group than in the 6h transportation group and the control group. Apoptotic proteins Bcl-2 and Bax were mainly expressed in the bronchial epithelium at all levels as well as in the alveolar septum. Autophagy-associated LC3B proteins were distributed in the cytoplasm of alveoli and bronchioles, and p62, PINK1 and Parkin proteins were widely expressed in the alveolar epithelium and the cytoplasm of cells in specific sites and nuclei. Also, there was a significant downregulation of PINK1 and Parkin proteins after the 6h transportation. Apoptosis-associated Bcl-2 and Bax genes and autophagy-associated LC3B, p62, PINK1 and Parkin genes showed different degrees of dysregulation after a certain time of transport, respectively. Conclusion The results of our study indicate that transportation stress could lead to an up-regulation of apoptosis rate in goat lung cells, which exhibited both a significant effect on the expression levels of apoptosis-related Bcl-2 and Bax genes, and triggered a dysregulation of autophagy-related LC3B, p62, PINK1 and Parkin genes, suggesting that transportation stress is closely related to apoptosis and autophagy in the lungs of goats.