bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term and long-term survival outcomes for transrectal specimen extraction after laparoscopic right hemicolectomy: a propensity-score matching study
Authors: ReDati DaRebai , Li Weikun , Jiang Yujuan , Yang Xinhui , Lei Cheng , Wang Haijiang , Liang Jianwei 
Published: January 2024

BackgroundNatural orifice specimen extraction surgery (NOSES) has been widely applied to the treatment of colorectal cancer. This study aim to investigate the short-term and survival outcomes of transrectal specimen extraction after laparoscopic right hemicolectomy.MethodsFrom January 2016 to December 2021, a total of 166 consecutive patients with right colon cancer who underwent laparoscopic right hemicolectomy in Cancer Hospital of Chinese Academy of Medical Sciences and Beijing Hospital were identified. Baseline data, perioperative parameters, anal function, inflammatory indicators and survival outcomes were collected and compared.ResultsTotally, 24 patients who underwent transrectal NOSE were matched with 24 patients who received conventional laparoscopic surgery (LAP). Patients in NOSES group had a significantly lower incidence of incision infection (0 vs 20.8%, P=0.048), faster recovery of gastrointestinal function (2.1 vs 3,1 days, P=0.032) compared with those in LAP group. In addition, patients in the NOSE group experienced significantly less postoperative pain on POD1 (2.3 vs 4.4, P&lt;0.001), POD3 (2.1 vs 3.9, P&lt;0.001), and POD5 (1.7 vs 2.8, P=0.011). Regarding to anal function 6 months after surgery, no significant difference was observed in Wexner incontinence scale (9.8 vs 9.5, P=0.559) between the two groups. In terms of indicators of the inflammatory response, there were no significant differences in body temperature, neutrophils, and PCT levels between the two groups. However, CRP levels in the NOSES group on POD 3 (6.9 vs 5.1 mg/L, P=0.016) and POD 5 (3.8 vs 2.6 mg/L, P=0.027) were significantly higher than in the LAP group. With regarded to survival outcomes, patients in the NOSES group were similar to those in the LAP group for 3-year OS (100% vs 91.2%, P=0.949), 3-year DFS (86.2% vs 84.8%, P=0.949), and 3-year LRFS (94.2% vs 88.7%, P=0.549).ConclusionFor total laparoscopic right hemicolectomy, transrectal NOSE is effective and safe, and associated with lower incidence of wound infection, less pain, faster recovery, and similar survival outcomes compared to conventional laparoscopic surgery.
Effects of surgical management for gastrointestinal stromal tumor patients with liver metastasis on survival outcomes
Authors: Liu Lei , Xia Xiaomin , Ju Yiheng , Zhang Simeng , Shi Ning , Du Yongxing , Zhan Hanxiang , Liu Shanglong 
Published: January 2024

PurposeTo investigate the effect of surgical resection on survival in gastrointestinal stromal tumors synchronous liver metastasis (GIST-SLM) and to develop clinically usable predictive models for overall survival (OS) and cancer-specific survival (CSS) in patients.MethodsWe identified patients in the SEER database diagnosed with GISTs from 2010 to 2019. We used propensity score matching (PSM) to balance the bias between the Surgery and No surgery groups. Kaplan-Meier(K-M) analysis was used to detect differences in OS and CSS between the two groups. The nomogram to predict 1, 3, and 5-year OS and CSS were developed and evaluated.ResultsAfter PSM, 228 patients were included in this study. There were significant differences in 1, 3, and 5-year OS and CSS between the two groups (OS: 93.5% vs. 84.4%, 73.2% vs. 55.3%, 60.9% vs. 36.9%, P=0.014; CSS: 3.5% vs.86.2%,75.3% vs.57.9%, 62.6% vs. 42.9%, P=0.02). We also found that patients who received surgery combined with targeted therapy had better OS and CSS at 1, 3, and 5 years than those who received surgery only (OS: 96.6% vs.90.9%, 74.9% vs. 56.8%, 61.7% vs. 35.5%, P=0.022; CSS: 96.6% vs. 92.1%, 77.4% vs.59.2%,63.8% vs. 42.0%, P=0.023). The area under the curve (AUC) was 0.774, 0.737, and 0.741 for 1, 3, and 5-year OS, respectively, with 0.782 and 0.742 for 1, 3, and 5-year CSS. In the model, C-index was 0.703 for OS and 0.705 for CSS and showed good consistency.ConclusionSurgical treatment can improve the OS and CSS of patients with GIST-SLM. In addition, the combination with chemotherapy may be more favorable for the long-term survival of patients. Meanwhile, we constructed the nomograms for predicting OS and CSS at 1, 3, and 5-year, and validated them internally. Our model can contribute to clinical management and treatment strategy optimization.
Basic motor competencies in Slovak children from the 3rd and 4th grade elementary age group
Authors: Šiška Ľuboslav , Mačura Peter , Hubinák Andrej , Krška Peter , Sedláček Jaromír , Blahutová Anna , Zvonař Martin , Kohútová Katarína , Štefan Lovro 
Published: January 2024

BackgroundThe development of movement skills is the basic goal of physical and sports education. Their level is a determining factor in the subsequent involvement of the child in physical activities. Goal is to contribute to the knowledge of basic motor competencies (BMC) in the 3rd and 4th grade boys and girls from elementary schools.MethodsWe collected data from 468 children (Mage = 9.6, SD = 0.6 years; 228 girls and 240 boys) from 16 third grade and 16 fourth grade classes at ten elementary schools in different parts (central, west, north) of the Slovak Republic. The primary data on the basic motor competencies of the examined groups were obtained by means of the MOBAK-3 test battery. Construct validity was analyzed by confirmatory factorial analysis and relationships between BMC and age, gender and BMI were analyzed by structural equation modeling.ResultsBoys had a better performance in object movement activities than the girls p &lt; 0.01. Situation in self-movement activities was different, girls had a better performance than boys p &lt; 0.05. The general expectation that grade is a factor to improve the performance in basic motor competencies in the compared 3rd- and 4th-graders was not clearly fulfilled. This assumption was only confirmed in girls (object movement p &lt; 0.05, self movement p &lt; 0.01). Confirmatory factor analysis confirmed the two-factor structure of basic motor competencies on object-movement and self-movement, while gender, BMI and age were confirmed as significant covariances.ConclusionsThe theory of BMC in the 3rd- and 4th-graders at elementary schools is an appropriate method to uncover the grounds for a positive attitude to physical activities later in life.
Cardioprotective and hypotensive mechanistic insights of hydroethanolic extract of Cucumis melo L. kernels in isoprenaline-induced cardiotoxicity based on metabolomics and in silico electrophysiological models
Authors: Wahid Muqeet , Saqib Fatima , Abbas Ghulam , Shah Shahid , Alshammari Abdulrahman , Albekairi Thamer H. , Ali Anam , Khurm Muhammad , Mubarak Mohammad S. 
Published: January 2024

Background: Cardiovascular diseases (CVD) continue to threaten health worldwide, and account for a significant portion of deaths and illnesses. In both developing and industrialized nations, they challenge their health systems. There are several traditional uses of Cucurbitaceae seeds in Pakistan, India, Iran, and China, including treating cardiovascular, neurological, and urogenital diseases.Methods: In the present work, integrated techniques of metabolomics profiling and computational cardiomyocyte stimulation were used to investigate possible mechanisms of C. melo in isoprenaline (ISO)-induced myocardial infarction. In vitro, vasoconstrictions, paired atria, and in vivo invasive blood pressure measurement models were performed to explore the mechanism of action of C. melo hydroethanolic seed extract (Cm-EtOH).Results: Results showed that Cm-EtOH demonstrates NO-based endothelium-derived relaxing factor (EDRF) vasorelaxant response, negative chronotropic and inotropic response in the atrium, and hypotensive effects in normotensive rats. Results also revealed that Cm-EtOH decreases cardiomyocyte hypertrophy and reverts the altered gene expressions, biochemical, and metabolites in ISO-induced myocardial infarction (MI) rats. The extract additionally reversed ISO-induced MI-induced oxidative stress, energy consumption, and amino acid metabolism. Moreover, C. melo seeds increased EDRF function, energy production, and antioxidant capacity to treat myocardial and vascular disorders. In computational cardiomyocyte simulation, gallic acid reduced action potential duration, upstroke velocity (dV/dtmax), and effective refractory period.Conclusion: This study highlights the therapeutic potential of C. melo seeds to treat cardiovascular diseases and provides mechanistic insight into its antihypertensive and cardioprotective activities.
Population pharmacokinetics and individualized dosing of tigecycline for critically ill patients: a prospective study with intensive sampling
Authors: Su Wei , Song Shuping , Liu Jieqiong , Yu Haitao , Feng Binbin , Wu Yinshan , Guo Feng , Yu Zhenwei 
Published: January 2024

Background: Due to the heterogeneity of critically ill patients, the pharmacokinetics of tigecycline are unclear, and the optimal dosing strategy is controversial.Methods: A single-center prospective clinical study that included critically ill patients who received tigecycline was performed. Blood samples were intensively sampled (eight samples each), and plasma drug concentrations were determined. A population pharmacokinetic (PPK) model was developed and evaluated by goodness-of-fit plots, bootstrap analysis and visual predictive checks. Monte Carlo simulation was conducted to optimize the dosage regimen.Results: Overall, 751 observations from 98 patients were included. The final PPK model was a two-compartment model incorporating covariates of creatinine clearance on clearance (CL), body weight on both central and peripheral volumes of distribution (V1 and V2), γ-glutamyl transferase and total bilirubin on intercompartment clearance (Q), and albumin on V2. The typical values of CL, Q, V1 and V2 were 3.09 L/h, 39.7 L/h, 32.1 L and 113 L, respectively. A dosage regimen of 50 mg/12 h was suitable for complicated intra-abdominal infections, but 100 mg/12 h was needed for community-acquired pneumonia, skin and skin structure infections and infections caused by less-susceptive bacteria.Conclusion: The Tigecycline PPK model was successfully developed and validated. Individualized dosing of tigecycline could be beneficial for critically ill patients.
Charge identification of fragments produced in 16O beam interactions at 200 MeV/n and 400 MeV/n on C and C2H4 targets
Authors: Galati G. , Boccia V. , Alexandrov A. , Alpat B. , Ambrosi G. , Argirò S. , Barbanera M. , Bartosik N. , Battistoni G. , Bisogni M. G. , Bruni G. , Cavanna F. , Cerello P. , Ciarrocchi E. , Colombi S. , De Gregorio A. , De Lellis G. , Di Crescenzo A. , Di Ruzza B. , Donetti M. , Dong Y. , Durante M. , Faccini R. , Ferrero V. , Finck C. , Fiorina E. , Francesconi M. , Franchini M. , Franciosini G. , Galli L. , Ionica M. , Iuliano A. , Kanxheri K. , Kraan A. C. , La Tessa C. , Lauria A. , Torres E. Lopez , Magi M. , Manna A. , Marafini M. , Massa M. , Massimi C. , Mattei I. , Mengarelli A. , Mereghetti A. , Minniti T. , Moggi A. , Morone M. C. , Morrocchi M. , Muraro S. , Pastrone N. , Patera V. , Pennazio F. , Peverini F. , Placidi P. , Pullia M. , Ramello L. , Reidel C. , Ridolfi R. , Salvi L. , Sanelli C. , Sarti A. , Sato O. , Savazzi S. , Scavarda L. , Schiavi A. , Schuy C. , Scifoni E. , Sciubba A. , Servoli L. , Silvestre G. , Sitta M. , Spighi R. , Spiriti E. , Tioukov V. , Tomassini S. , Tommasino F. , Toppi M. , Traini G. , Trigilio A. , Ubaldi G. , Valetti A. , Vanstalle M. , Villa M. , Weber U. , Zarrella R. , Zoccoli A. , Montesi M. C. 
Published: January 2024

Introduction: Charged Particle Therapy plays a key role in the treatment of deep-seated tumours, because of the advantageous energy deposition culminating in the Bragg peak. However, knowledge of the dose delivered in the entrance channel is limited by the lack of data on the beam and fragmentation of the target.Methods: The FOOT experiment has been designed to measure the cross sections of the nuclear fragmentation of projectile and target with two different detectors: an electronic setup for the identification of Z ≥ 3 fragments and a nuclear emulsion spectrometer for Z ≤ 3 fragments. In this paper, we analyze the data taken by exposing four nuclear emulsion spectrometers, with C and C2H4 targets, to 200 MeV/n and 400 MeV/n oxygen beams at GSI Helmholtzzentrum für Schwerionenforschung (Darmstadt, Germany), and we report the charge identification of produced fragments based on the controlled fading induced on nuclear emulsion films.Results: The goal of identifying fragments as heavy as lithium has been achieved.Discussion: The results will contribute to a better understanding of the nuclear fragmentation process in charged particle therapy and have implications for refining treatment planning in the presence of deep-seated tumors.
TaRECQ4 contributes to maintain both homologous and homoeologous recombination during wheat meiosis
Authors: Bazile Jeanne , Nadaud Isabelle , Lasserre-Zuber Pauline , Kitt Jonathan , De Oliveira Romain , Choulet Frédéric , Sourdille Pierre 
Published: January 2024

IntroductionMeiotic recombination (or crossover, CO) is essential for gamete fertility as well as for alleles and genes reshuffling that is at the heart of plant breeding. However, CO remains a limited event, which strongly hampers the rapid production of original and improved cultivars. RecQ4 is a gene encoding a helicase protein that, when mutated, contributes to improve recombination rate in all species where it has been evaluated so far. MethodsIn this study, we developed wheat (Triticum aestivum L.) triple mutant (TM) for the three homoeologous copies of TaRecQ4 as well as mutants for two copies and heterozygous for the last one (Htz-A, Htz-B, Htz-D).ResultsPhenotypic observation revealed a significant reduction of fertility and pollen viability in TM and Htz-B plants compared to wild type plants suggesting major defects during meiosis. Cytogenetic analyses of these plants showed that complete absence of TaRecQ4 as observed in TM plants, leads to chromosome fragmentation during the pachytene stage, resulting in problems in the segregation of chromosomes during meiosis. Htz-A and Htz-D mutants had an almost normal meiotic progression indicating that both TaRecQ4-A and TaRecQ4-D copies are functional and that there is no dosage effect for TaRecQ4 in bread wheat. On the contrary, the TaRecQ4-B copy seems knocked-out, probably because of a SNP leading to a Threonine&gt;Alanine change at position 539 (T539A) of the protein, that occurs in the crucial helicase ATP bind/DEAD/ResIII domain which unwinds nucleic acids. Occurrence of numerous multivalents in TM plants suggests that TaRecQ4 could also play a role in the control of homoeologous recombination. DiscussionThese findings provide a foundation for further molecular investigations into wheat meiosis regulation to fully understand the underlying mechanisms of how TaRecQ4 affects chiasma formation, as well as to identify ways to mitigate these defects and enhance both homologous and homoeologous recombination efficiency in wheat.
Exercise self-efficacy remains unaltered during military service
Authors: Kekäläinen Tiia , Pulkka Antti-Tuomas , Kyröläinen Heikki , Ojanen Tommi , Helén Joonas , Pihlainen Kai , Heikkinen Risto , Vaara Jani P. 
Published: January 2024

BackgroundExercise self-efficacy is a crucial aspect of adopting and maintaining a physically active lifestyle. Regular physical activity may enhance exercise self-efficacy. This study aimed to investigate the baseline associations of physical fitness, physical activity, and body composition with exercise self-efficacy and the effects of military service on exercise self-efficacy. Methods: The sample consisted of healthy young Finnish conscripts (n = 243) undergoing military service. The participants were divided into two groups: an intervention group undergoing a high-intensity functional training program (n = 113) and a control group undergoing traditional physical training within their military service (n = 130). Exercise self-efficacy (adoption and barrier) and aerobic and muscular fitness were measured thrice (baseline, month 3, and month 5). Self-reported leisure-time physical activity and measured fat percentage were collected at baseline.ResultsAdoption and barrier exercise self-efficacy correlated positively with aerobic and muscular fitness and leisure time physical activity (r = 0.33–0.59, p &lt; 0.001), and barrier self-efficacy negatively with fat percentage (r = −0.15, p &lt; 0.05) at baseline. No changes in adoption (time p = 0.912) and barrier self-efficacy (time p = 0.441) occurred during the military service. There were no differences between groups in these changes (group × time interaction p = 0.643 for adoption self-efficacy and p = 0.872 for barrier self-efficacy). Change in muscular fitness correlated positively with change in barrier self-efficacy in the high-intensity functional training group (r = 0.35, p &lt; 0.05). Conclusions: Exercise self-efficacy is positively associated with physical fitness and physical activity among young males. However, military service, whether it involves high-intensity functional physical training or more diverse traditional physical training, does not improve exercise self-efficacy.
Association between love breakup and suicidal ideation in Peruvian medical students: a cross-sectional study during the COVID-19 pandemic
Authors: Valladares-Garrido Danai , Zila-Velasque J. Pierre , Santander-Hernández Flor M. , Guevara-Morales Miguel A. , Morocho-Alburqueque Noelia , Failoc-Rojas Virgilio E. , Pereira-Victorio César Johan , Vera-Ponce Víctor J. , León-Figueroa Darwin A. , Valladares-Garrido Mario J. 
Published: January 2024

ObjectiveWe aimed to determine the association between a major romantic breakup and suicidal ideation in medical students from three universities in Peru.MethodsA cross-sectional study was conducted during the first pandemic wave in 2021 on medical students from three universities in northern Peru. The outcome was suicidal ideation, measured with question nine of the Patient Health Questionnaire-9 (PHQ-9). Generalized Anxiety Disorder Scale-7 (GAD-7) and Insomnia Severity Index (ISI) were also used to assess mental health symptoms. The exposure was the experience of a major love breakup during the pandemic. In addition, its association with other covariates (age, sex, family members infected with COVID-19, deceased family members with COVID-19, insomnia, and anxiety, among others) was examined.Results and discussionsOut of 370 students, 19.5% reported a major love breakup during the pandemic (95%CI: 15.5–23.8), and 34.3% had suicidal ideation (95%CI: 29.4–39.4). Having a major love breakup was associated with a higher prevalence of suicidal ideation (PR: 1.49, 95%CI: 1.32–1.67, p &lt; 0.001). Moderate insomnia (PR: 2.56, 95%CI: 1.70–3.87, p &lt; 0.001) and anxiety symptoms (PR: 1.94, 1.10–3.44, p = 0.023) were also associated with suicidal ideation.ConclusionOur study provides evidence of a significant association between a major love breakup and suicidal ideation. This finding emphasizes the need for further research to better understand this association and inform the development of effective suicide prevention policies in medical education.
Measuring for change/Mobile Creches
Authors: Vohra Chavi , Shah Minal , Mishra Atishi , Gupta Ankita 
Published: January 2024

IntroductionResearch spanning decades across fields such as psychology, education, and neuroscience consistently highlights the crucial role of social–emotional skills in various aspects of personal, academic, and professional development (1–3). The fact that UNESCO recognises social–emotional learning (SEL) as essential not just for meeting its educational objectives but also for accomplishing the Sustainable Development Goals highlights the crucial role robust social–emotional development plays in establishing sustainable societies. Whilst various studies highlight the importance of SEL, there is limited attention on how organizations can contribute to building such development by consciously including SEL in their work practice.Process/methodsOur case study presents the process of integrating SEL into organizational practice over a period of 9 months. The selected constructs of SEL were determined by the organisation’s needs and values. The Measurement for Change approach was used to frame and implement the intervention, with interactive discussions being the key methodology. Data were collected via surveys, reflective sharing, and observations.ResultsA shift in the selected constructs of SEL was recorded, with data highlighting individual differences.ConclusionThe process of co-design and continual reflective practice was key to achieving change within the subset of the organisation rather than the specific content of the materials used.
Utilization of long-lasting insecticide-treated net and its associated factors among pregnant women in Dawo district, Southwest Shoa Zone, Oromia, Ethiopia, 2023
Authors: Negasa Kumsa , Huluka Tufa Kolola , Yebassa Mecha Aboma , Waqkene Tolossa 
Published: January 2024

IntroductionThe use of long-lasting insecticide-treated net (LLIN) is one of the most effective malaria prevention strategies, particularly among pregnant women. It has mosquito-killing repellent and physical barrier properties. Pregnant women, children under 5 years of age, and patients with HIV/AIDS, as well as non-immune migrants, mobile populations, and travelers, are the most vulnerable groups to malaria. Even when pregnant women are given priority, not all nets owned by households are used by pregnant women. Therefore, the risk of the occurrence of malaria during pregnancy is also high.ObjectiveThis study aimed to assess the utilization of long-lasting insecticide-treated net and its associated factors among pregnant women in Dawo district, Southwest Shoa Zone, Oromia, Ethiopia, 2023.MethodsA community-based analytical cross-sectional study was carried out in Dawo district, Southwest Shoa Zone, Oromia, Ethiopia, from 21 to 30 April 2023. A total of 353 pregnant women were chosen through simple random sampling and interviewed face-to-face using a structured and pre-tested questionnaire. Before being exported to the Statistical Package for Social Science (SPSS) version 23, the data were coded and entered into EPIDATA version 4.6. The study examined the prevalence of long-lasting insecticide-treated net use among pregnant women in the Dawo district using descriptive statistics. Analytical statistics, such as bivariable and multivariable logistic regression analyses, were used to determine the relationship between independent and dependent variables. Statistical significance was determined using a P-value of &lt;0.05 and adjusted odd ratios with 95% confidence intervals.ResultsLong-lasting insecticide-treated nets were utilized by 55.5% (95% CI: 50.4–60.7%) of all pregnant participants in the study, which was below the national target. Pregnant women who have antenatal care (ANC) contact for current pregnancy adjusted odds ratio (AOR = 4.66, 95% CI: 1.95, 11.10), community-based health insurance (CBHI) enrollment (AOR = 2.38, 95% confidence intervals, CI: 1.38, 4.11), children under 5 years of age (AOR = 2.68, 95% CI: 1.62, 4.43), understanding that malaria poses a risk to fetuses (AOR = 3.25, 95% CI: 1.26, 8.41), and LLINs access (AOR = 12.47, 95% CI: 3.98, 39.08), were factors that significantly associated with LLIN utilization.ConclusionIn conclusion, the utilization of LLINs was relatively low. ANC contact for current pregnancy, CBHI enrollment, having children under the age of 5, having a high income, and understanding that malaria poses a risk to fetuses were factors significantly associated with LLIN utilization among pregnant women.