bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on partial replacement of HDPE and PP waste plastic for M30 and M40 grade concrete
Authors: Suvidha Y , Jain Sumesh , Kumar C. Arvind 
Published: November 2023

Abstract
In the present paper two different plastic materials High Density Polyethylene (HDPE) and Polypropylene (PP) was replaced with fine aggregate (FA) till 10% by 2.5% increment. Different test such as compressive strength (3, 7, 28 & 60 days) (150x150x150mm), flexural strength (3, 7, 28 & 60 days) (100x100x500mm), acid attack (28, 56 & 90 days)(100x100x100mm), sulphate attack (28, 56 & 90 days)(100x100x100mm), thermal conductivity (180mm dia x 20mm thick). The compressive strength of 40.52MPa and 38.41Mpa for PP and HDPE material was observed in M30 grade concrete respectively. Similarly, for M40 grade concrete 43.6MPa and 41.8MPa for PP and HDPE material respectively. The optimum percentage of 5% and 7.5 for PP and HDPE material respectively can be replaced in concrete for flexural strength for both M30 and M40 grade. The least percentage loss in acid attack was observed at 28 days for both HDPE and PP material but for 56days and 90 days the percentage loss of weight was significantly less (< 5%). The sulphate attack for both M30 and M40 grade concrete showed less than 10% percentage loss in weight till 90 days. Thermal conductivity (k) was also reduced by 30–35% for both HDPE and PP material till 10% replacement in concrete for M30 and M40 grade.
Isoorientin alleviates DSS-treated acute colitis in mice by regulating intestinal epithelial P-glycoprotein (P-gp) expression.
Authors: wang Zhenzhen , Yang Lanzhu , Feng Yun , Duan Bensong , Zhang Haibin , Yang Jingya , Tang Yanru , Zhang Caihang 
Published: November 2023

Abstract
Background
Isoorientin (ISO) is a naturally-occurring flavonoid with diverse functional properties that mitigate the risk of diseases stemming from oxidation, inflammation and cancer cell proliferation. P-glycoprotein (P-GP) is a vital component of the intestinal epithelium, and alterations in P-gp expression and functionality may play a role in the onset of intestinal inflammatory conditions, such as inflammatory bowel disease (IBD). Recent studies have suggested that short-chain fatty acids (SCFAs) and secondary bile acids produced by the gut microbiota, stimulate the increase in operational P-gp expression, alleviating excessive inflammation, and thereby aid the preservation of intestinal homeostasis. ISO has been shown to improve colon health and modulate gut microbiota. However, whether ISO can modulate the microbes and their metabolites to influence P-gp expression to alleviate IBD is unknown.
Results
First, the impact of ISO on dextran sulfate sodium (DSS)-treated colitis was investigated in mice. The present study indicated that ISO mitigated the symptoms and pathological damage associated with DSS-treated colitis in mice with ulcerative colitis. Western blot analysis revealed that ISO upregulated P-gp in colon tissues (P < 0.05), suggesting the critical role of P-gp protein in intestinal epithelial cells. It was speculated that ISO may maintain intestinal homeostasis by upregulating functional P-gp expression in the intestinal epithelium. 16S microbial diversity sequencing revealed that ISO restored the richness and variety of intestinal microorganisms in colitis-bearing mice and enriched short-chain fatty acid-producing bacteria, such as Lachnospiraceae_NK4A136_group. The experiments also revealed that the ISO fecal microbial transplantation (FMT) inoculation of DSS-treated mice had similarly beneficial results. FMT mice showed a reduction in colitis symptoms, which was being more pronounced in ISO-FMT than in CON-FMT mice. Meanwhile, ISO-FMT expanded the abundance of beneficial microorganisms such as the Lachnospiraceae_NK4A136_group, increased the expression of metabolites, such as SCFAs and total serum bile acids (SBAs), and significantly upregulated the expression level of P-gp protein. In addition, Spearman’s correlation analysis of metabolites demonstrated a positive correlation between the production of SCFAs and SBAs and the expression of P-gp.
Conclusion
The present study identified that ISO affects the heightened expression of P-gp in the intestinal epithelium by regulating intestinal microorganisms and their metabolites, which maintains colonic homeostasis, improves the integrity of the colonic epithelium, and alleviates colitis.
Development and internal validation of two prediction models of walking dependence and restricted walking speed in individuals with subacute stroke
Authors: Fukumoto Hiroto , Oyake Kazuaki , Kurobe Yasushi , Mizoguchi Hiroto , Sakai Takehiro , Momose Kimito 
Published: November 2023

Abstract
Background
The prognosis of the walking ability of individuals with stroke affects the choice of rehabilitation program. Identifying patients who will need assistance with ambulation at discharge allows clinicians to deliver rehabilitation programs focused on educating caregivers and adjusting the patient’s environment to allow safe transfer within the home. The primary objective of this study was to develop and internally validate a prediction model of walking dependence for patients with stroke admitted to a rehabilitation facility. The secondary objective was to establish a prediction model of restricted walking speed.
Methods
This retrospective cohort study included 476 individuals with subacute stroke who were admitted to a rehabilitation facility. Model 1 was developed to predict the probability of walking dependence. Model 2 was developed to predict restricted walking speed. Walking dependence was defined as a functional independence measure walk score of 5 or less. Restricted walking speed was defined as the ability to walk at 0.93 m/s or less. Potential predictors, including age, leg strength of the affected side, sitting balance, cognitive function, and urinary function, were selected based on the literature and analyzed using logistic regression analysis. Models were internally validated using the bootstrap method. Model performance was assessed by discrimination (area under the receiver operating characteristic curve (AUC)) and calibration (Hosmer–Lemeshow (H–L) goodness-of-fit test and calibration plots).
Results
A total of 236 patients (49.6%) walked dependently at discharge. Of the 240 individuals who achieved walking independence, 121 (50.4%) had restricted walking speed. In model 1, older age, poor leg strength, sitting balance, cognitive function, and urinary incontinence were significantly associated with walking dependence at discharge. The AUCs of models 1 and 2 were 0.93 (95% confidence interval (CI) = .90–.95) and 0.69 (95%CI = .62–.76), respectively. Both models had good calibration confirmed by the H-L test.
Conclusions
The internally validated prediction model of walking dependence had good discrimination and calibration, while the prediction model of restricted walking speed had poor discrimination. The prediction model for walking dependence developed in this study may be useful for planning rehabilitation strategies and setting realistic goals for patients.
A Novel Green Biosynthesis Approach and Structural Characterization of Ag–Fe Bimetallic Nanoparticles using the Red Alga Galaxaura rugosa
Authors: Ali Elham M. , Elsayed Ashraf , Shehawy Ahlam S. El 
Published: November 2023

Abstract
A Novel green and eco-friendly approach has been used to biosynthesize Ag-Fe bimetallic nanoparticles (Ag-FeBNPs), mediated by an aqueous extract of the red alga species; Galaxaura rugosa. The surface plasmon resonance band is positioned at 264 nm for Ag-FeBNPs. X-ray diffraction analysis (XRD) illustrated the crystalline nature of biogenic nanoparticles. Transmission electron microscopy (TEM) and selected area electron diffraction (SAED) showed that the particles have a crystalline spherical shape with a size range from 14.3 to 22.1 nm. Scanning electron microscopy (SEM) and Energy dispersive analysis (EDAX) give the surface morphology and elemental composition of Ag-FeBNPs which is spherical in high intensity. Fourier transmittance infrared spectroscopy (FTIR) showed that the biomolecules are responsible for forming and stabilizing Ag-FeBNPs. Zeta potential values show − 15.7 mV. The findings of this study documented the great potentiality of Ag-FeBNPs that would significantly impact the field of nanobiotechnology and nanoscience in the future.
Effect of different seedbeds on performance of rice seedlings under different nursery structure during early spring
Authors: Bastola Saraswatai , Yadav Pankaj Kumar , Ghimire Sangam , Marahattha Santosh 
Published: November 2023

Abstract
Early spring rice shows seedling failure in nursery during the colder months due to low temperature. This experiment evaluates the effect of different nursery structure and nursery seedbed on seedling growth. The experiment was laid out in two factorial split plot design with three replications. Among the two factors, one factor was nursery structure including gumose, straw cover, plastic cover and open field; and another factor was nursery seedbed including tray, plastic mat and normal. Among nursery structure better growth of seedlings were observed in the plastic mat whereas in nursery seedbeds growth of seedling was better in gumose but seedling ready for planting is earlier under plastic cover. Seedling sown in the plastic mat under the gumose showed better growth of seedlings. This can be recommended as the appropriate technique for nursery establishment during early spring.
Rethinking Geographic Thought in the Digital Space; A Review of the Arguments for Sustainability and Resilience
Authors: Arthur Jones Lewis 
Published: November 2023

Abstract
The study delves into the realm of Geographic Thought, emphasizing its significance in the context of contemporary global digital spaces. It also explores the intersection of Geographic Thought with artificial intelligence (AI) and its potential impact on sustainability and resilience within the field of geography. Employing the document analysis approach, the research scrutinizes this subject, demonstrating the method's pertinence in geography and various other academic domains. Document analysis, as the chosen research method, aids in unearthing valuable insights within the realm of geography. Whether investigating historical transformations, spatial patterns, environmental concerns, or other geographical themes, document analysis plays a pivotal role. The study methodically identifies research questions and assesses content in alignment with these inquiries, considering elements such as patterns, themes, trends, and connections across diverse sources. Spatial and temporal aspects, including location, scale, and temporal changes, are also examined to provide a comprehensive understanding of geographical issues. Thematic summaries extracted from this analysis contribute significantly to comprehending the geographical problem at hand. The research underscores AI as a potent tool for unravelling the intricate web of life exploration, human behaviour, urban dynamics, and human-environment interaction. However, it cautions users about the challenges that may arise when applying AI to sustainability and resilience studies, particularly when handling vast datasets. Nevertheless, AI is seen as a catalyst for enhancing geographic thought, enabling more nuanced interpretations and applications in the realm of sustainability and resilience. The study suggests a critical fusion of resilience and sustainability with geographic thought to effectively address the multifaceted socio-environmental challenges of our time. In essence, Geographic Thought, in conjunction with AI, can pave the way for a more comprehensive and insightful approach to geography's pivotal role in promoting sustainable and resilient solutions.
Tingginya Angka Calon Tunggal Pemilihan Kepala Daerah dan Melemahnya Demokrasi di Indonesia Kontemporer
Authors: Hannan Abd 
Published: November 2023

Meningkatnya angka calon tunggal dalam gelaran Pilkada serentak di Indonesia menuai ragam polemik, salah satunya adalah adanya anggapan bahwa Pilkada calon tunggal telah menyebabkan proses sirkulasi kepemimpinan daerah berjalan tidak sehat, memperlemah sistem demokrasi, dan cenderung memperkokoh praktik monopoli kekuasaan di tingkat daerah. Studi ini mengkaji fenomena meningginya calon tunggal dalam gelaran pemilihan kepala daerah, dampak dan pengaruhnya terhadap sistem demokrasi dan dinasti kekuasaan di Indonesia. Dengan melakukan analisa berdasarkan perspektif sosiologi hukum dan sosiologi politik, studi ini mendapati temuan bahwa sejak diterapkannya Pilkada serentak pada tahun 2015, praktik Pilkada calon tunggal mengalami peningkatan. Meningginya jumlah calon tunggal tersebut disebabkan oleh adanya pragmatisme politik di level elit, tidak optimalnya partai politik menjalankan fungsinya, serta diterapkannya syarat ambang batas pencalonan. Pada tataran praktiknya, Pilkada calon tunggal telah mereduksi prinsip esensial pemilihan umum, khususnya prinsip partisipasi, kompetisi, danprinsip kontestasi sehingga membuat bangunan demokrasi Indonesia melemah. Selain itu, Pilkada calon tunggal juga dinilai telah membuat dinasti kekuasaan di tingkat daerah semakin menguat. Faktanya, dari jumlah 25 calon tunggal yang bertarung pada Pilkada serentak 2020, sebanyak 23 calon merupakan incumbent baik sebagai calon kepaladaerah atau wakil kepala daerah, dan 10 di antaranya merupakan kepala daerah yang kembali maju dengan pasangan calon yang sama.
NOTAS SOBRE BACTERIAS COLIFORMES EN EL CAMARÓN Heterocarpus reedi BAHAMONDE
Authors: García Tello Patricio , Iturriaga Rodolfo , Vera Alicia 
Published: November 2023

Generalmente las investigaciones sobre la presencia de bacterias coliformes en productos perecibles del mar se hacen a partir del elaborado después que estos han sido manipulados.
En el presente trabajo se pretende conocer camarones de pesca comercial capturados frente a la costa de Valparaíso se encuentran contaminados con este tipo de bacterias, debido a que su captura se realiza entre 3 y 7 millas de la costa y con frecuencia frente a cwentros poblados de alguna importancia.
Treatment of Teeth with Root Resorptions: A Case Report and Systematic Review
Authors: Erkal Damla , Başoğlu Abdullah , Kırıcı Damla , Kayar Nezahat Arzu , Koç Simay , Er Kürşat 
Published: November 2023

Aim. This article presents an evaluation of different multidisciplinary treatment approaches to managing teeth with external and internal root resorptions.
Methods. This study presents a clinical case of a 35-year-old female patient referred to Akdeniz University for dental issues. A comprehensive review of the literature was conducted, encompassing 21 articles sourced from PubMed and Web of Science over the past decade, including case reports and case series.
Results. Case Report. A clinical case of a 35-year-old female patient seeking treatment for dental aesthetic concerns was reported and discussed. Intraoral examination revealed discoloration of maxillary anterior teeth and a sinus tract in the apical region of tooth #11. The resorption area was sealed with mineral trioxide aggregate. Afterward, the coronal part of the root was filled using the warm-vertical compaction method. During the final visit, non-vital bleaching was applied to teeth #11 and #21. After all these procedures, aesthetic coronal restorations were completed. Systematic Review. In the context of this clinical case, a literature review was conducted, encompassing an assessment of a total of 25 cases of external and internal resorptions. Among these cases, a combination of surgical and endodontic treatments was applied in 12 cases, while non-surgical endodontic treatment was performed in 13 cases.
Conclusions. In the present case report, a patient who had both external and internal root resorptions was treated with mineral trioxide aggregate and flap operation, with no subsequent complications during the follow-up sessions. Among the 21 reports included in our review, 24 out of 25 treated teeth demonstrated successful outcomes, while only one tooth necessitated extraction.
Pengembangan video pembelajaran tari Jepin Kembang Manggar untuk siswa SMA
Authors: Rizky Oktaviari Satrianingsih Aline , Cantik Putri Aditya Mega , Oktariani Dwi , Patriantoro Patriantoro 
Published: November 2023

Tujuan penelitian Pengembangan Video Pembelajaran Tari Jepin Kembang Manggar untuk siswa kelas X SMA di Kota Pontianak ini ada tiga hal yaitu: (1) Mengembangkan media pembelajaran Tari Jepin Kembang Manggar melalui video; (2) Mengetahui kelayakan produk video pembelajaran interaktif Tari Jepin Kembang Manggar. Video pembelajaran Tari Jepin Kembang Manggar merupakan pengembangan media pembelajaran yang disesuaikan untuk siswa kelas X SMA di Kota Pontianak. Target secara umum untuk mengetahui ketertarikan siswa kelas X SMA di Kota Pontianak dalam mempelajari Tari Jepin Kembang Manggar sebagai salah satu tari tradisional melalui video pembelajaran yang telah tervalidasi ahli materi dan ahli media. Metode penelitian ini adalah Research and Development (RnD), sehingga didapatkan hasil yang layak dari video tutorial Tari Jepin Kembang Manggar yang sudah tervalidasi oleh ahli materi, ahli media, dan siswa calon pengguna.Kata kunci: media pembelajaran tari, Jepin Kembang Manggar Developing Jepin Kembang Manggar dance learning videos for high school students AbstractThe research objectives of developing a Jepin Kembang Manggar dance learning video for class X SMA students in Pontianak City are three things, namely: (1) Developing learning media for the Jepin Kembang Manggar Dance through video; (2) Knowing the feasibility of the Jepin Kembang Manggar Dance interactive learning video product. The Jepin Kembang Manggar Dance learning video is the development of learning media adapted for class X high school students in Pontianak City. The general target is to determine the interest of the class. This research method is Research and Development (RnD), so that decent results are obtained from the Jepin Kembang Manggar Dance video tutorial which has been validated by material experts, media experts, and prospective student users.Keywords: dance learning media, Jepin Kembang Manggar
EVALUATION OF VITAMIN-D LEVELS IN CHILDREN WITH TYPE-1 DIABETES MELLITUS
Authors: YADAVELLI PRITHVI , VADE VAMSHIDHAR REDDY , DEVINENI SATYASRI 
Published: November 2023

Objective: Vitamin D supplementation during pregnancy and early childhood decreases the risk of autoimmune diabetes, and perhaps even after the onset of diabetes, it may improve glycemic control. Hence, the present study focuses on evaluating vitamin D levels in type-1 DM.
Methods: It is a case-control study conducted on children aged from 6 y to 15 y who presented with type 1 DM and were admitted to the Department of Pediatrics, Dr. Patnam Mahender Reddy Institute of Medical Sciences, Chevella. Diabetic Mellitus was studied using a predesigned and pre-tested proforma. 100 children in the age group of 6-15 y were included, further divided into two groups. Children with Type 1 DM were enrolled as cases, while the normal children were enrolled as controls. Information was collected from the patient or attender or relative about the sociodemographic profile, dietary intake, and treatment history. A detailed clinical examination of the child was conducted with exact anthropometric measurements. Metabolic profile was done by investigating fasting blood sugar, postprandial blood sugar, and glycosylated hemoglobin. Blood samples were collected from all participants for measurement of hematological parameters. A Minividas analyzer estimated vitamin D, the Chemiluminescence method.
Results: Most children with Type 1 DM were 10-14 y old, and the mean age of the cases was 11.36. This study's female-to-male ratio was 1.3:1 (29 and 21), respectively. In this study, we found that 38(76%) children were in the deficiency range, the majority in the age group of 10-14 y, while 7(14%) children were in the insufficiency range, only 5(10%) were in the sufficiency range. The significant finding in this study was the mean Vitamin D level for cases was 16.81, while in comparison, controls had a mean Vitamin D level of 25.74; it was significant.
Conclusion: The present study revealed that the prevalence of vitamin D deficiency and insufficiency among T1 diabetes children was very high.
A CLINICOPATHOLOGICAL ANALYTIC STUDY OF OVARIAN TUMOURS OVER A TWO-YEAR PERIOD IN A TEACHING HOSPITAL
Authors: BARLA KOMAL SAHITHI , CHANDRASEKHAR VIJAYALAKSHMI , G. VASUNDARA , MADHAVI B. V. 
Published: November 2023

Objective: The aim of this retrospective study was to analyze the clinical, demographic and pathological aspects of ovarian tumours diagnosed and operated upon over a two-year period.
Methods: A total of sixty women diagnosed with ovarian tumours who underwent an operative procedure formed our study group. All clinical and demographic data were obtained from medical records and the histopathology reports of the tissues removed at surgery were retrieved from the pathology department records.
Results: 36.7% of the women belonged to the age group of 41-50 y and lower abdominal pain was the commonest symptom in 61.7% of the women. 93.10% of the ovarian tumours were found to be benign, 1.7% to be borderline and 5.17% were malignant. Benign surface epithelial tumours constituted 74.13% of the total and, of these the incidence of serous cystadenoma was 44.8% and mucinous cytadenoma 22.41%. Germ cell tumours constituted 13.8% of all the tumours, with mature cystic teratomas being the most prevalent at 12.06%. Serous cystadenocarcinoma accounted for 5.17% of the tumours and borderline serous tumours accounted for 1.72%.
Conclusion: Women presenting with symptoms of an ovarian tumour should undergo a detailed clinical evaluation, investigations, early interventions and histopathology should be an integral component to improve outcomes.
DESIGNING AND EVALUATION OF FLURBIPROFEN SODIUM SUPPOSITORIES
Authors: KUMAWAT RUMITA , RATHORE KAMAL S. , BHARKATIYA MEENAKSHI 
Published: November 2023

Objective: The present investigation was aimed to develop Flurbiprofen Sodium suppositories by using different suppository bases with a view to avoid loss of drug by first pass effect and to minimize toxic effects, thereby producing safe and effective dosage form which will improve the solubility and absorbability of poorly soluble drug.
Methods: Fusion method was used for the preparation of suppositories. Pre formulation studies of the drug was done by determining its physical appearance, melting point, IR spectrum, UV spectrum and solubility studies of Flurbiprofen sodium were carried out in different Solvents.
Results: Melting point of Flurbiprofen sodium was found to be in the range 114 °C-117 °C. UV spectrum of Flurbiprofen sodium in ethanol at pH7.4 was determined at 273 nm. Calibration curve of Flurbiprofen sodium in pH 6.4 phosphate buffer were constructed in the concentration range of 0-20 μg/ml. The prepared suppositories of each batch was evaluated for their physio-chemical properties like weight variation, Hardness, Friability, length and width, melting point, breaking strength, disintegration test, content uniformity, in vitro drug release and stability studies. The prepared suppositories were smooth and fine in texture with mechanical strength (hardness) i.e. can tolerate less than 5.0 kg. The friability was found to be within acceptable limits (less than 1%).
Conclusion: Suppositories were successfully formulated and evaluated. The type of base employed for the preparation of suppositories influenced the release of the drug during the dissolution studies. They can be arranged in order of release rate as-PEG 4000>PEG 6000>Cocoa butter. The use of Sodium lauryl sulphate also influenced the release rate of the drug and the release rate patterns of all formulations.