bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-quality Momordica balsamina genome elucidates its potential use in improving stress resilience and therapeutic properties of bitter gourd
Authors: Vinay N. D. , Singh Kalpana , Ellur Ranjith Kumar , Chinnusamy Viswanathan , Jaiswal Sarika , Iquebal Mir Asif , Munshi Anilabha Das , Matsumura Hideo , Boopalakrishnan G. , Jat Gograj Singh , Kole Chittaranjan , Gaikwad Ambika Baladev , Kumar Dinesh , Dey Shyam Sundar , Behera Tusar Kanti 
Published: January 2024

IntroductionMomordica balsamina is the closest wild species that can be crossed with an important fruit vegetable crop, Momordica charantia, has immense medicinal value, and placed under II subclass of primary gene pool of bitter gourd. M. balsamina is tolerant to major biotic and abiotic stresses. Genome characterization of Momordica balsamina as a wild relative of bitter gourd will contribute to the knowledge of the gene pool available for improvement in bitter gourd. There is potential to transfer gene/s related to biotic resistance and medicinal importance from M. balsamina to M. charantia to produce high-quality, better yielding and stress tolerant bitter gourd genotypes.MethodsThe present study provides the first and high-quality chromosome-level genome assembly of M. balsamina with size 384.90 Mb and N50 30.96 Mb using sequence data from 10x Genomics, Nanopore, and Hi-C platforms.ResultsA total of 6,32,098 transposons elements; 2,15,379 simple sequence repeats; 5,67,483 transcription factor binding sites; 3,376 noncoding RNA genes; and 41,652 protein-coding genes were identified, and 4,347 disease resistance, 67 heat stress–related, 05 carotenoid-related, 15 salt stress–related, 229 cucurbitacin-related, 19 terpenes-related, 37 antioxidant activity, and 06 sex determination–related genes were characterized.ConclusionGenome sequencing of M. balsamina will facilitate interspecific introgression of desirable traits. This information is cataloged in the form of webgenomic resource available at http://webtom.cabgrid.res.in/mbger/. Our finding of comparative genome analysis will be useful to get insights into the patterns and processes associated with genome evolution and to uncover functional regions of cucurbit genomes.
Untargeted metabolomics profiling of oat (Avena sativa L.) and wheat (Triticum aestivum L.) infested with wheat stem sawfly (Cephus cinctus Norton) reveals differences associated with plant defense and insect nutrition
Authors: Hager Megan S. , Hofland Megan L. , Varella Andrea C. , Bothner Brian , Budak Hikmet , Weaver David K. 
Published: January 2024

IntroductionWheat stem sawfly (WSS), Cephus cinctus Norton, is a major pest of common bread wheat (Triticum aestivum L.) and other cultivated cereals in North America. Planting of cultivars with solid stems has been the primary management strategy to prevent yield loss due to WSS infestation, however expression of this phenotype can vary depending on environmental conditions and solid stems hinder biological control of WSS via braconid parasitoids Bracon cephi (Gahan) and Bracon lissogaster Muesebeck. In the hollow stems of oat (Avena sativa L.), WSS larvae experience 100% mortality before they reach late instars, but the mechanisms for this observed resistance have not been characterized. ObjectiveThe objective of this study was to explore additional sources of resistance outside of the historic solid stem phenotype.MethodsHere, we use an untargeted metabolomics approach to examine the response of the metabolome of two cultivars of oat and four cultivars of spring wheat to infestation by WSS. Using liquid chromatography-mass spectrometry (LC-MS), differentially expressed metabolites were identified between oat and wheat which were associated with the phenylpropanoid pathway, phospholipid biosynthesis and signaling, the salicylic acid signaling pathway, indole-3-acetic acid (IAA) degradation, and biosynthesis of 1,4-benzoxazin-3-ones (Bxs). Several phospho- and galacto- lipids were found in higher abundance in oat, and with the exception of early stem solidness cultivar Conan, both species experienced a decrease in abundance once infested. In all wheat cultivars except Conan, an increase in abundance was observed for Bxs HMDBOA-glc and DIBOA-β-D-glucoside after infestation, indicating that this pathway is involved in wheat response to infestation in both solid and hollow stemmed cultivars. Differences between species in compounds involved in IAA biosynthesis, degradation and inactivation suggest that wheat may respond to infestation by inactivating IAA or altering the IAA pool in stem tissue.ConclusionWe propose that the species differences found here likely affect the survival of WSS larvae and may also be associated with differences in stem architecture at the molecular level. Our findings suggest pathways to focus on for future studies in elucidating plant response to WSS infestation.
The effectiveness of Balint group work on the quality of work life, resilience, and nurse–patient communication skills among psychiatric nurses: a randomized controlled trial
Authors: Yousefzadeh Negar Kiani , Dehkordi Mansoureh Kiani , Vahedi Mohsen , Astaneh Ali Nazeri , Bateni Fatemeh Sadat 
Published: January 2024

BackgroundBalint group training has gained popularity in medical practices as an intervention designed to enhance the quality of life, well-being, and communication skills of healthcare practitioners. Psychiatric nurses, in particular, encounter distinct challenges and stressors inherent in their profession, necessitating the development and implementation of effective interventions to assist them in coping with the difficulties they experience. In this vein, the current study aimed to investigate the effectiveness of Balint group training on quality of work life, resilience, and nurse–patient communication skills among psychiatric nurses.MethodsThirty psychiatric nurses from Razi Hospital in Tehran were recruited via the purposeful sampling method in 2022 and were randomly assigned to either the Balint group, consisting of eight weekly one-hour training sessions, or a control group. Participants completed the Walton Quality of Work Life Questionnaire, Connor-Davidson Resilience Scale, and Communication Skills Scale before and after the intervention. The data were analyzed using the Analysis of Covariance (ANCOVA).ResultsThe study found no significant differences between the Balint group and the control group in terms of quality of work life, resilience, and nurse–patient communication skills.ConclusionFindings suggest that Balint group training was not an effective intervention for improving the well-being and communication skills of psychiatric nurses. However, the study highlights the need for further investigation into the potential factors that may explain the lack of significant gains and offers insights for future research in this area.
The relationship between ostracism and negative risk-taking behavior: the role of ego depletion and physical exercise
Authors: Chen Fang , Wang Jinhong , Gao Heng , Zeng Yadi , Li Ziwei , Zou Hongyu 
Published: January 2024

BackgroundAs a major public health problem globally, negative risk-taking behavior of college students may be related to their ostracism experience, but the reason for this association is unclear. Based on the limited resource theory, combined with the integrative model of athletic performance, we tested a moderated mediation model in which ego depletion mediated the association between ostracism and risk-taking, and physical exercise moderated the mediation process to examine the mechanisms underlying the association between ostracism and negative risk-taking behavior.MethodsOne thousand three hundred seven students (43% female) from four universities in China were recruited using cluster random sampling. The experience of being ostracized, ego depletion, physical exercise level, and negative risk-taking behavior were measured through an anonymous online questionnaire in “www.sojump.com.”ResultsAfter controlling for gender and grade in college, ostracism was positively related to negative risk-taking behavior; ego depletion mediated this relationship; and physical exercise level attenuated these direct and indirect relationships.ConclusionThe results highlight individual risk and protective factors associated with negative risk-taking behavior, and provide new perspectives on ways to prevent and reduce college students’ negative risk-taking behavior.
Adapting the ADVANCE group program for digitally-supported delivery to reduce intimate partner violence by men in substance use treatment: a feasibility study
Authors: Gilchrist Gail , Dheensa Sandi , Johnson Amy , Henderson Juliet , Radcliffe Polly , Dwyer Georges , Turner Richard , Thomson Kate , Papastavrou Brooks Cat , Love Beverly , Zenasni Zohra , Berbary Cassandra , Carter Ben , Parrott Steve , Li Jinshuo , Easton Caroline , Bergman Ciara , Feder Gene , Gilchrist Elizabeth 
Published: January 2024

IntroductionCOVID-19 restrictions created barriers to “business as usual” in healthcare but also opened the door to innovation driven by necessity. This manuscript (1) describes how ADVANCE, an in-person group perpetrator program to reduce intimate partner violence (IPV) against female (ex)partners by men in substance use treatment, was adapted for digitally-supported delivery (ADVANCE-D), and (2) explores the feasibility and acceptability of delivering ADVANCE-D to men receiving substance use treatment.MethodsFirstly, the person-based approach and mHealth development framework were used to iteratively adapt ADVANCE for digitally-supported delivery including conceptualization, formative research, and pre-testing. Then, a non-randomized feasibility study was conducted to assess male participants’ eligibility, recruitment, and attendance rates and uptake of support offered to their (ex)partners. Exploratory analyses on reductions in IPV perpetration (assessed using the Abusive Behavior Inventory; ABI) and victimization (using the revised ABI; ABI-R) at the end of the program were performed. Longitudinal qualitative interviews with participants, their (ex)partners, and staff provided an understanding of the program’s implementation, acceptability, and outcomes.ResultsThe adapted ADVANCE-D program includes one goal-setting session, seven online groups, 12 self-directed website sessions, and 12 coaching calls. ADVANCE-D includes enhanced risk management and support for (ex)partners. Forty-five participants who had perpetrated IPV in the past 12 months were recruited, forty of whom were offered ADVANCE-D, attending 11.4 (SD 9.1) sessions on average. Twenty-one (ex)partners were recruited, 13 of whom accepted specialist support. Reductions in some IPV perpetration and victimization outcome measures were reported by the 25 participants and 11 (ex)partners interviewed pre and post-program, respectively. Twenty-two participants, 11 (ex)partners, 12 facilitators, and 7 integrated support service workers were interviewed at least once about their experiences of participation. Overall, the program content was well-received. Some participants and facilitators believed digital sessions offered increased accessibility.ConclusionThe digitally-supported delivery of ADVANCE-D was feasible and acceptable. Remote delivery has applicability post-pandemic, providing greater flexibility and access. Given the small sample size and study design, we do not know if reductions in IPV were due to ADVANCE-D, time, participant factors, or chance. More research is needed before conclusions can be made about the efficacy of ADVANCE-D.
Increasing and sustaining blood-borne virus screening in Spain and Portugal throughout the COVID-19 pandemic: a multi-center quality improvement intervention
Authors: Vaz-Pinto Inês , Ortega Enrique , Chivite Ivan , Butí María , Turnes-Vázquez Juan , Magno-Pereira Vítor , Rocha Miguel , Garrido Jorge , Esteves-Santos Catarina , Guimaraes Mafalda , Mourão Tomás , Martínez Roma María , Guilera Vanessa , Llaneras-Artigues Jordi , Barreira-Díaz Ana , Pérez Cachafeiro Santiago , Daponte Angueira Sandra , Xavier Elisa , Vicente Mariana , Garrido Gema , Heredia Maria Teresa , Medina Diogo , García Deltoro Miguel 
Published: January 2024

BackgroundAround 57,000 people in Spain and Portugal currently living with HIV or chronic hepatitis C are unaware of their infection. The COVID-19 pandemic severely disrupted screening efforts for these infections. We designed an intervention to increase and sustain opportunistic blood-borne virus (BBV) screening and linkage to care (SLTC) by implementing the TEST model.MethodsThe Plan Do Study Act (PDSA) method of quality improvement (QI) was implemented in 8 healthcare organizations (HCOs), including four hospitals, two clusters of community health centers, and two community-based organizations (CBOs). Baseline assessment included a review of BBV SLTC practices, testing volume, and results 12 months before the intervention. Changes in BBV testing rates over time were measured before, during, and after the COVID-19 lockdowns in 2020. A mixed ANOVA model was used to analyze the possible effect on testing volumes among HCOs over the three study periods.InterventionBBV testing was integrated into normal clinical flow in all HCOs using existing clinical infrastructure and staff. Electronic health record (EHR) systems were modified whenever possible to streamline screening processes, implement systemic institutional policy changes, and promote QI.ResultsTwo years after the launch of the intervention in screening practices, testing volumes increased by 116%, with formal healthcare settings recording larger increases than CBOs. The start of the COVID-19 lockdowns was accompanied by a global 60% decrease in testing in all HCOs. Screening emergency department patients or using EHR systems to automate screening showed the highest resilience and lowest reduction in testing. HCOs recovered 77% of their testing volume once the lockdowns were lifted, with CBOs making the fullest recovery. Globally, enhanced screening techniques enabled HCOs to diagnose a total of 1,860 individuals over the research period.ConclusionsImplementation of the TEST model enabled HCOs to increase and sustain BBV screening, even during COVID-19 lockdowns. Although improvement in screening was noted in all HCOs, additional work is needed to develop strong patient linkage to care models in challenging times, such as global pandemics.
Current status and influencing factors of activation of older patients with chronic disease
Authors: Yiran Zhu , Yan Zhang , Lijun Xing , Xizheng Li , Xinjie Zhang , Yutong Tian 
Published: January 2024

ObjectiveWe aimed to investigate the status and influencing factors of activation of older patients with chronic disease.MethodsWe conducted a cross-sectional study, using the general information questionnaire, Patient Activation Measure, the Chinese version of the e-Health Literacy Scale, and the Health Empowerment Scale for the Elderly with Chronic Disease. By the convenience sampling method, 289 older patients with chronic disease were selected from January to April 2023 in a Class A tertiary hospital in Zhengzhou.ResultsThe mean score of the Patient Activation Measure for older patients with chronic disease was 65.94 ± 13.35. The association of influencing factors such as religion, family income, health empowerment, e-health literacy, and patient activation was investigated.ConclusionThe patient activation of older patients with chronic disease was at a middle level. Patients without religion and from high-income families tended to have a higher level of patient activation. Improving health empowerment and e-health literacy levels promotes patient activation and enhances their self-health management ability.
Incidence of erectile dysfunction among middle-aged and aging sexual minority men living with or without HIV
Authors: Mustapha Aishat , Polanka Brittanny M. , Maini Mansi , Ware Deanna P. , Li Xiuhong , Hart Trevor A. , Brown Todd , Palella Frank , Gorbach Pamina M. , Ho Ken , Plankey Michael 
Published: January 2024

IntroductionErectile dysfunction (ED) has been established as a comorbidity among men living with HIV, but comparisons by HIV serostatus of ED incidence in a longitudinal follow-up cohort of men are lacking. We sought to evaluate the incidence of ED spanning a period of 12 years in a longitudinal cohort of sexual minority men (SMM) living with and without HIV.MethodsWe analyzed ED incidence data for 625 participants in the longitudinal Multicenter AIDS Cohort Study from visits spanning October 2006 to April 2019.ResultsSMM living with HIV were more likely to have incident ED compared with those living without HIV (rate ratio: 1.41; 95% CI: 1.14–1.75). Older age, current diabetes, cumulative cigarette use, and cumulative antidepressant use were associated with increased incidence of ED in the entire sample. Self-identifying as Hispanic, current diabetes, and cumulative antidepressant use were positively associated with ED incidence among SMM living with HIV. Cumulative cigarette use was positively associated with greater ED incidence only among SMM living without HIV.DiscussionIn summary, age (full sample/ with HIV), current diabetes (full sample/with HIV), cumulative cigarette use (full sample/without HIV), and cumulative antidepressant use (full sample/with HIV) were associated with increased ED incidence. Skillful management of diabetes and careful titration of antidepressants, along with smoking cessation practices, are recommended to mitigate ED in this population.
Research on the structure function recognition of PLOS
Authors: Liu Jiangfeng , Zhao Zhixiao , Wu Na , Wang Xiyu 
Published: January 2024

PurposeThe present study explores and investigates the efficiency of deep learning models in identifying discourse structure and functional features and explores the potential application of natural language processing (NLP) techniques in text mining, information measurement, and scientific communication.MethodThe PLOS literature series has been utilized to obtain full-text data, and four deep learning models, including BERT, RoBERTa, SciBERT, and SsciBERT, have been employed for structure-function recognition.ResultThe experimental findings reveal that the SciBERT model performs outstandingly, surpassing the other models, with an F1 score. Additionally, the performance of different paragraph structures has been analyzed, and it has been found that the model performs well in paragraphs such as method and result.ConclusionThe study's outcomes suggest that deep learning models can recognize the structure and functional elements at the discourse level, particularly for scientific literature, where the SciBERT model performs remarkably. Moreover, the NLP techniques have extensive prospects in various fields, including text mining, information measurement, and scientific communication. By automatically parsing and identifying structural and functional information in text, the efficiency of literature management and retrieval can be improved, thereby expediting scientific research progress. Therefore, deep learning and NLP technologies hold significant value in scientific research.
Green Synthesis of Gold and Copper Nanoparticles by Lannea discolor: Characterization and Antibacterial Activity
Authors: Rambau Unarine , Masevhe Nndivhaleni Anox , Samie Amidou 
Published: January 2024

Green synthesis using plant extracts has emerged as an eco-friendly, clean, and viable alternative to chemical and physical approaches. Herein, the leaf, stem, and root extracts of Lannea discolor were utilized as a reducing and stabilizing agent in synthesizing gold (AuNPs) and copper (CuNPs) nanoparticles. The formation of AuNPs and CuNPs, confirmed by their color change, was characterized by UV-Vis spectroscopy (UV-Vis), scanning electron microscopy analysis, and energy-dispersive X-ray (SEM-EDX), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR), coupled with minimum inhibitory concentration (MIC) antibacterial assays. Gold nanoflowers (AuNFs), NPs, and CuNPs peaked at wavelengths of 316, 544, and 564 nm, respectively. TEM showed unexpected nanoflowers (30–97 nm) in the leaf extracts and spherical NPs (10–33 nm; 9.3–37.5) from stem and root extracts, while spherical CuNPs (20–104 nm) were observed from all the extracts. EDX confirmed the presence of metal salts, and FTIR revealed stable capping agents. AuNPs and NFs from L. discolor extracts showed appreciable antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Klebsiella pneumoniae (ATCC 700603), and Bacillus subtilis (ATCC 6633) when compared to the plant extracts. At the same time, none was observed from the CuNPs. These AuNPs and CuNPs are particularly appealing in various biomedical and conductivity manufacturing applications due to their shapes and sizes and economical and environmentally friendly production. To our knowledge, this is the first study of the synthesis of gold and copper nanoparticles from L. discolor.
POLA PEMBERIAN MAKAN DENGAN KEJADIAN STUNTING PADA BAYI (6-24) BULAN DI PUSKESMAS BABIRIK
Authors: Muti’ah  , Istiqamah Istiqamah , Darsono Putri Vidiasari 
Published: January 2024

Latar Belakang: Stunting adalah masalah gizi yang terjadi sebagai akibat dari kekurangan gizi dalam kurun waktu yang cukup lama. Menurut WHO Child Grwoth Standart Stunting dasarkan pada indeks panjang badan dibanding umur (PB/U) atau tinggi badan dibanding umur (TB/U) dengan batas (z-score)kurang dari 2-SD.Pola asuh pemberian makan merupakan kemampuan orangtua dan keluarga untuk menyediakan waktu perhatian dan dukungan dalam memberikan makanan kepada anaknya.
Tujuan: Mengetahui pola asuh pemberian makan dengan kejadian stunting pada balita 06 – 24 bulan di wilayah kerja UPT Puskesmas Babirik.
Metode: analisis kuantitatif dengan pendekatan crosssectional. Penelitian dilakukan di wilayah kerja UPT Puskesmas Babirik. Dengan populasi ibu yang memiliki balita stunting dan sampel diambil dengan menggunakan metode purvosive sampling.Populasi dalam penelitian ini adalah ibu yang memiliki balita stunting. sebanyak 30 orang. Data dianalisis menggunakan uji fisher extact.
Hasil: Hasil penelitian menunjukkan terdapat hubungan antara pola pemberian makan dengan kejadian stunting pada bayi/balita usia 6-24 bulan (p=0,007).