bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation of Bioelectricity in Microbial Fuel Cell using Kitchen Waste Obtained from Dutse Urban, Nigeria
Authors: Haruna Sadiq , Yusuf Hindatu , Gumel Ahmad Muhammed , Buhari Aisha Salisu , Abubakar Umar Umar 
Published: January 2024

Microbial fuel cells (MFCs) have shown promise as a sustainable technology for wastewater treatment and energy recovery. In this study, cattle dung was used as an inoculum and kitchen waste (KW) from Dutse urban, Nigeria was used as a substrate for bioelectricity generation in MFC. The MFC was operated in a fed-batch mode over 37 days, spanning three cycles. During characterization, the chemical oxygen demand (COD) of the KW was found to be 30421 ± 124 mg/L, indicating a high concentration of organic pollutants. The MFC's performance was evaluated based on the voltage generated, with the first cycle reaching a peak of 254 mV, the second cycle 247 mV, and the third cycle 242 mV. Current and power densities during the three cycles decreased gradually from 66.84 mA/m² and 16.84 mW/m² in the first cycle to 63.68 mA/m² and 15.41 mW/m² in the third cycle respectively. Furthermore, there was a notable reduction in COD from the influent diluted from initial measured COD, from 1120 ± 63 mg/L to an effluent level of 226 ± 49 mg/L, indicating approximately 80% removal rate. The pH of the anolyte progressively dropped with each cycle, reflecting the metabolic activities of bacteria in the anode chamber. The findings underscore MFC's potential for organic waste management and electricity generation, with results outperforming some contemporary studies.
ELAVL1 ameliorates sevoflurane induced neurotoxicity by inhibiting NLRP3 inflammasome activation
Authors: Xia Yan , Wang Kunguang , Chen Yan , Du Xiaoxuan 
Published: January 2024

Purpose: To investigate the role of embryonic lethal-abnormal vision like protein 1 (ELAVL1) in sevoflurane-induced neurotoxicity.
Methods: A cell model was established in HT22 cells by exposing them to 3 % sevoflurane for 12 h. The HT22 cells were transfected with siRNA ELAVL1 (si-ELAVL1) or siRNA negative control (si-NC) to knockdown ELAVL1 expression. Enzyme-linked immunosorbent assay (ELISA) was performed to assess the levels of proinflammatory factors in HT22 cell culture supernatants. Cell apoptosis was analyzed using flow cytometry while apoptosis-related proteins and NLRP3 inflammasome pathway proteins were determined by western blot.
Results: ELAVL1 was upregulated in sevoflurane-exposed HT22 cells. Sevoflurane exposure also resulted in inflammation, apoptosis and activation of NLRP3 inflammasome of HT22 cells. Importantly, knockdown of ELAVL1 inhibited inflammation and apoptosis in HT22 cells caused by sevoflurane through the inhibition of IL-6, IL-1β and TNF-α production and bys regulating Bax and Bcl-2 protein expression. Furthermore, knockdown of ELAVL1 suppressed NLRP3 inflammasome activity as reflected by the inhibition of the expression of caspase 1, ASC, IL-1β and IL-18.
Conclusion: The findings of this study suggest that the knockdown of ELAVL1 alleviates the inflammation and apoptosis of HT22 cells induced by sevoflurane which impeded the activation of NLRP3 inflammasome, suggesting that ELAVL1 would make a good therapeutic target for sevoflurane-caused neurotoxicity.
Pitavastatin calcium significantly improves glucose and lipid metabolism of patients with coronary atherosclerosis and reduces the occurrence of adverse cardiovascular events
Authors: Liu Jun , Li Bing , Wang Cuiping 
Published: January 2024

Purpose: To determine the efficacy of pitavastatin calcium and atorvastatin calcium on coronary atherosclerosis (CA) and compare the influence of the two schemes on adverse cardiovascular events.
Methods: The medical records of 198 patients with CA admitted at Affiliated Hospital of Jiangsu University, China from August 2019 to May 2011 were analyzed retrospectively. The patients were grouped into pitavastatin calcium group (n = 102) and atorvastatin calcium group (n = 96). The efficacy, incidence of adverse cardiovascular events, as well as changes in blood lipid metabolism and blood glucose metabolism indices before and after therapy were recorded and compared.
Results: Compared with atorvastatin calcium group, pitavastatin calcium group yielded a significantly higher overall response rate (ORR, p < 0.05) and presented a significantly lower total incidence of cardiovascular adverse events (p < 0.05). After therapy, pitavastatin calcium group displayed significantly lower triglyceride, total cholesterol and low-density lipoprotein-cholesterol levels (p < 0.05), and also presented significantly higher high-density lipoprotein-cholesterol levels (p < 0.05) in contrast to atorvastatin calcium group. Furthermore, pitavastatin calcium group presented significantly lower fasting blood glucose and glycosylated hemoglobin levels than atorvastatin calcium group (p < 0.05).
Conclusion: Compared with atorvastatin calcium, pitavastatin calcium displays a better therapeutic effect in patients with CA, lowers the incidence of adverse cardiovascular events and improves glucose and lipid metabolism of patients. Future studies will focus on longer follow-up sessions to better understand the impact of the drugs on patient’s prognosis.
Application of a combination of lactated Ringer's solution and ulinastatin for early resuscitation in sepsis
Authors: Min Yuyuan , He Yinbin , Tuo Lei , Fan Meizi , Xie Yaning 
Published: January 2024

Purpose: To investigate the effect of early resuscitation using a combination of lactated Ringer's solution and ulinastatin on the survival rate of patients with sepsis.
Methods: 82 patients with septic shock admitted to Xi'an People's Hospital, China from June 2017 to December 2020 were enrolled and randomly divided into control and study groups (n = 41 each). Patients in control group were given conventional fluid resuscitation and anti-infective therapy, while patients in study group were additionally given ulinastatin. Acute physiology and chronic health evaluation (APACHE II) score, sequential organ failure assessment (SOFA) score, and tissue perfusion were determined. Also, mechanical ventilation time, intensive care unit (ICU) stay time, and 28-day mortality rates were recorded.
Results: Both groups presented no significant difference in clinical characteristics before treatment. After treatment, APACHE II score, SOFA score, and lactic acid level of the study group significantly decreased (p < 0.05), and the patients’ condition improved. Moreover, inflammation-related indices, viz, procalcitonin (PCT), white blood cells (WBC), and C reactive protein (CRP) were significantly reduced in the study group (p < 0.05). Renal function-related indices which include creatinine, and blood urea nitrogen (BUN) significantly decreased in study group (p < 0.05). Mechanical ventilation time, and ICU stay time were significantly shortened (p < 0.0001), while short-term survival rate significantly improved (p < 0.05).
Conclusion: Lactated Ringer's solution in combination with ulinastatin expedites tissue perfusion and recovery, suppresses inflammation, enhances renal function, and significantly enhances the survival rate of septic patients. These findings provide valuable information for exploring new therapeutic approaches to sepsis.
Efficacy of recombinant human brain natriuretic peptide as an adjuvant therapy for severe heart failure, and its impact on oxidative stress and quality of life in patients
Authors: Zeng Yanping , Ma Weixing , Xue Hua , Ma Cheng , Wang Yan , Ren Xiaohui , Jiang Zhenhua 
Published: January 2024

Purpose: To evaluate the efficacy of recombinant human brain natriuretic peptide as an adjuvant therapy for severe heart failure, and its effect on oxidative stress and quality of life in patients.
Methods: The study was conducted on 100 patients with severe heart failure who met the screening criteria for this study. They were evenly but randomly divided into two groups. Patients in the control group were given routine treatment (diuretics and cardiac stimulants) for severe heart failure, while the study group received recombinant human brain natriuretic peptide adjuvant therapy in addition to the treatment administered to the control group. Cardiac function, heart rate, oxidative stress indicators, quality of life levels, and adverse drug reactions during treatment were compared before and after treatment.
Results: After the intervention, the NT-proBNP level in the study group was significantly lower than in the control group while LVEF level was significantly higher than in the control group (p < 0.05). Compared with the control group, the study group showed a significant decrease in heart rate (p < 0.05). The MDA level of the study group was significantly lower than that of the control group while the SOD and GSH-PX levels were significantly higher than those of the control group (p < 0.05). In addition, the GQOLI-74 score of the study group was significantly higher than that of the control group (p < 0.05). Furthermore, there was no statistically significant difference in incidence of adverse reaction between control and study groups (14.0 and 16.0 %, respectively, p < 0.05).
Conclusion: Recombinant human brain natriuretic peptide has a significant therapeutic effect on severe heart failure, thus improving patients' cardiac function, alleviating their oxidative stress state and enhancing their quality of life, and is also safe.
Local anesthetic effect and safety of ropivacaine oily solution
Authors: Lu Wudang , Yao Tong , Hui Minquan , Gu Jingliang , Wu Manli , Zhou Liqiang , Yang Yi , Cao Lei , Cao Yongxiao 
Published: January 2024

Purpose: To investigate the effectiveness and safety of ropivacaine oily solution (ROPOS).
Methods: After effecting nerve block in postoperative rats by injection of ROPOS near the sciatic nerve, the expression levels of sodium-potassium-chloride co-transporter 1 (NKCC1) and potassium-chloride co-transporter 2 (KCC 2) in the spinal dorsal horn, were assayed. The safety of ROPOS in beagle dogs was evaluated through subcutaneous injection.
Results: The duration of anesthetic effect of ROPOS was 5 times longer than that of ropivacaine hydrochloride injection. The analgesic effect occurred via downregulation of the expression of NKCC1. Dogs administered ROPOS had acute inflammatory reactions at the injection sites within 3 days, but they recovered after 14 days. No other toxic reactions were observed. The Tmax values for dogs subcutaneously injected with ROPOS at doses of 15, 30 and 60 mg/kg were 2.15 ± 3.09, 6.25 ± 9.62 and 14.85 ± 11.82 h; with the Cmax values of 0.78 ± 0.51, 1.35 ± 0.38 and 2.09 ± 0.53 µg/mL, while the AUC(0-48h) values were 15.88 ± 5.41, 31.46 ± 11.45 and 66.10 ± 17.81 h·µg/mL, respectively. The values of Tmax, Cmax and AUC(0-48h) were positively correlated with ROPOS dose.
Conclusion: Ropivacaine oily solution has a longer duration of local anesthetic effect than ropivacaine hydrochloride injection and it also possesses a good safety profile. The acute inflammatory reactions are noteworthy and will be further investigated in subsequent studies.
Effect of Mongolian medicine alcohol spray therapy on fracture healing in rabbits
Authors: Wu Qilatu A, Rihan , Su Rilige 
Published: January 2024

Purpose: To evaluate the healing effect and mechanism of Mongolian medicine alcohol spray therapy on fracture healing process in rabbits.
Methods: Thirty New Zealand white rabbits were randomly divided into normal, fracture, and treatment groups, with 10 rabbits in each group. Fracture and treatment groups underwent bone-fracture modeling, with the latter receiving daily alcohol spraying and stroking for six weeks. Serum calcium and phosphorus were measured using an automatic biochemical analyzer. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of BMP-2, ALP, and TGF-β. Biomechanical testing was performed to assess callus properties, and real-time polymerase chain reaction (PCR) and western blot were performed to assess BMP-2, Runx2, and p-Smad1/5 expressions in callus.
Results: There were low serum calcium, phosphorus, BMP-2, ALP, and TGF-β levels in fracture and treatment groups, compared to normal group. Similarly, treatment group showed significantly increased levels of serum calcium, phosphorus, bone morphogenetic protein 2 (BMP-2), alkaline phosphatase (ALP), and transforming growth factor-β (TGF-β) (p < 0.05) compared to fracture group. Biomechanical testing revealed that maximum load, stiffness, and deflection of callus in the fracture and treatment groups were significantly lower compared to normal group (p < 0.05). expressions of BMP-2, Runx2, and p-Smad1/5 mRNA in the callus significantly decreased in both fracture and treatment groups compared to normal group (p < 0.05). However, treatment group showed significantly increased expression levels compared to fracture group (p < 0.05).
Conclusion: Mongolian medicine alcohol spray therapy promotes fracture healing in rabbits and increases maximum load of the callus, possibly through upregulation of the BMP-2 signaling pathway. Further research is necessary to confirm the exact mechanism by which alcohol spray therapy regulates BMP-2 signaling pathway.
La construcción de la identidad gráfica de las instituciones públicas de Galicia en la posmodernidad (1979-1999): la reinterpretación de los símbolos propios a partir de los mitos-de-lugar
Authors: Dopico Castro Marcos , Vázquez Gómez Jesús , Rico López Cibrán 
Published: January 2024

La llegada de la democracia a España supuso la descentralización del Estado y una oportunidad para repensar una compleja identidad cuyas diferentes sensibilidades nacionales habían sido cercenadas y perseguidas durante la dictadura. El diseño emergió como una herramienta de vanguardia, y la identidad visual de los nuevos estamentos políticos; ministerios, autonomías, diputaciones, ayuntamientos y demás entidades territoriales abordaron una urgente renovación de su imagen con resultados dispares. En Galicia, la primera generación de diseñadores y diseñadoras con conciencia de serlo, protagonizaron una búsqueda de novedosos símbolos identitarios.

Siguiendo las nuevas ideas posmodernas, reinterpretaron la tradición desde la esquina atlántica en contraposición al concepto de «mediterraneidad» dominante. Recurrieron a los símbolos ancestrales como la vieira del peregrino, la Cruz de Santiago, los símbolos de la cultura castrexa o las reinterpretaciones de heráldica con la complicidad política de instituciones que buscaban una identidad singular y un encaje propio. Los estudios de diseño construyen sobre las ideas de sus predecesores, aquellos diseñadores-artistas que habían intentado el proyecto casi utópico de los años sesenta y setenta del Laboratorio de Formas de Galicia. El diseño gráfico en la Galicia de los ochenta y noventa se movió entre la contradicción de descubrir, al mismo tiempo, el rigor del proyecto moderno y los nuevos postulados posmodernos. Este artículo pretende analizar las singularidades del diseño corporativo institucional y territorial en Galicia en la época posmoderna, mediante la reinterpretación de una serie de símbolos propios como mitos-de-lugar que han definido hasta la actualidad una identidad gráfica diferenciada.
PROSPECTS AND CHALLENGES OF EDUCATING A DEAF-BLIND STUDENT IN A UNIVERSITY IN GHANA
Authors: Dogbe Daniel S. Q. , Anku Francis Kwame 
Published: January 2024

This study explored the challenges and prospects of educating a deaf-blind student in a public university in Ghana. The study utilised an exploratory qualitative research design based on interviews and observation to explore how the deaf-blind learner navigated university life. The study found that the challenges experienced by all stakeholders included a lack of knowledge and understanding about deaf-blindness, communication challenges, inadequate preparation of educators/teachers and resource persons, lack of support structures for all stakeholders, and the time-consuming nature needed to educate the deaf-blind learner. The study recommends continuous in-service training on basic knowledge of deaf-blindness, instructional and socially inclusive strategies, and communication modes for deaf-blind learners for all stakeholders. A collaborative team approach to delivering training and inclusive education that involves all stakeholders is necessary. The study concludes that if lecturers of learners who are deaf-blind are provided with the necessary training on the skills and knowledge of facilitating communication with their students, this would, in turn, contribute positively towards teaching and learning.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0662/a.php" alt="Hit counter" /></p>
ENHANCING THE QUALITY OF GENERAL PHYSICS EDUCATION THROUGH PROJECT-BASED LEARNING: A STUDY AT THE UNIVERSITY OF INFORMATION TECHNOLOGY AND COMMUNICATIONS
Authors: Huong Duong Thi Thu 
Published: January 2024

The article explores the impact of Project-Based Learning (PBL) on General Physics education. The study, conducted with 120 students at a Vietnamese university, utilizes a mixed-method approach combining theoretical research, expert opinions, and data analysis. It examines the shift from traditional teaching to PBL, emphasizing hands-on, real-world problem-solving to improve understanding and application of physics concepts. The findings indicate significant positive outcomes in student engagement, understanding, and satisfaction. The study also discusses the challenges and considerations in implementing PBL, the importance of teacher training, and the potential for scalability and long-term impact in diverse educational settings.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0611/a.php" alt="Hit counter" /></p>
EQUIVALENCE OF PARABOLA΄S DEFINITIONS WITHIN MATHEMATICAL MACHINES SIMULATED BY “GEOGEBRA”
Authors: Ntontos Georgios K. , Koleza Eugenia 
Published: January 2024

This paper aims to highlight two historical parabolographs and a third one that is at the design level and to prove the equivalence of the respective definitions of parabola they contain. Specifically, using the Geogebra math software, each mechanism is attempted to articulate another, so that by moving the cursor of the original mechanism to the common output of the two articulated mechanisms, the same parabola is drawn. This proves the equivalence of definitions of parabolic curve as well as of suitably articulated mathematical machines.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0661/a.php" alt="Hit counter" /></p>
Proses Mandi Tujuh Bulanan Tradisi Masyarakat Banjar Di Kelurahan Selat Utara Kecamatan Selat Kabupaten Kapuas
Authors: Almira Riski Amanda, Fimeir Liadi, Muhammad Husni  
Published: January 2024

Tradisi Mandi Tujuh Bulanan hingga saat ini masih tetap dilaksanakan dan berlaku bagi setiap wanita yang hamil anak pertama. Secara umum makna dari prosesi mandi tujuh bulan ini bermakna adalah agar dalam proses melahirkan nanti dapat berjalan dengan lancar dan selamat hal ini terlihat dari beberapa rangkaian proses yang dilakukan. Tradisi mandi 7 bulanan merupakan adat kebiasaan yang dilakukan secara turun temurun oleh masyarakat banjar khususnya ibu yang hamil anak pertama pada usia kandungan memasuki 7 bulan. Upacara 7 bulanan adalah sebagai bentuk syukur kepada allah karean sebentar lagi bayi yang di kandung akan lahir ke dunia. Upacara ini di harapakan bisa menjadi doa untuk anak yang di kandung agar selalu taat kepada allah dan bisa bebakti kepada kedua orang tuanya. Ketika upacara di gelar, si ibu yang akan di mandikan berada pada dalam pagar mayang untuk di mandikan. Setelah selesai mandi 7 bulanan si ibu yang hamil tersebut rambutnya di sisir, di rias, dan di beri pakaian yang bagus. Upacara ini di akhiri dengan bersalaman sambil mendoakan kepada si ibu yang mandi tersebut. Penelitian ini menunjukan bahwa tradisi yang turun temurun tetap bertahan di tengah masyarakat, meskipun gempuran budaya modernisasi dan globalisasi budaya dengan dahsyat menerpa, hal ini disebabkan budaya Tradisional seperti mandi Tujuh Bulanan menjadi salah satu keyakinan yang diyakini oleh masyarakat secara kuat dan memberikan efek manfaat bagi masyarakat itu sendiri .
Adverse events following immunization among children during primary immunizations in selected health facility of Himachal Pradesh
Authors: Sharma Neeti , Pugazhendi Sanchita , Semwal Jayanti , Prakash Kamli 
Published: January 2024

Background: Vaccine related problems are commonly reported after immunizations and are a matter of concern for health care professionals. A study on the pattern and rate of incidences of vaccine related problems was conducted among children undergoing primary immunizations. Materials and methods: The study was conducted in Zonal hospital, Solan, Himachal Pradesh. 150 mothers and their children undergoing immunization were enrolled in the study using systematic random sampling and followed on every immunization event until nine months. Vaccine related problems were enquired at every immunization events namely birth, six weeks, ten weeks, fourteen weeks and nine months using a self-structured tool to assess vaccine related problems among children. Results: Pain at vaccination site, redness and swelling, excessive crying, fever, and sleep related problems, feeding problems and fever were common AEFIs reported by mothers among children. Conclusion: AEFIs are frequent and need to be reported. None of the child had any severe reaction or hospitalization after immunization.
Evaluation of Phytochemical and Antioxidant Potential of Lepidagathis Pungens Nees: A Therapeutic Application
Authors: R Jothi Lakshmi , R Srinivasan 
Published: January 2024

ANTIOXIDANT POTENTIAL AND PHYTOCHEMICAL PROFILING OF LEPIDAGATHIS PUNGENS NEES: A COMPREHENSIVE ANALYSIS FOR THERAPEUTIC APPLICATIONS

Abstract:
This study aimed to investigate the physicochemical properties, heavy metal content, inorganic elements, extract parameters, and antioxidant activities of Lepidagathis pungens Nees, a plant with potential health-promoting properties. The physicochemical analysis revealed the presence of ash values, moisture content, total fiber content, swelling index, and foaming index. Heavy metal content analysis showed that cadmium, nickel, mercury, lead, chromium, and arsenic levels were within the safe limits set by the World Health Organization, indicating the plant's safety for consumption. The presence of various essential inorganic elements such as calcium, chloride, copper, iron, magnesium, nitrate, phosphate, and potassium was also confirmed. Five different solvent extracts, including Oil ether, chloroform, ethyl acetate, methanol, and absolute ethanol extracts of the plant were obtained. from the whole plant, and their extractive values, colors, odors, and consistencies A determination was made. The methanol and aqueous extracts had the highest extractive values. The fluorescent analysis of the whole plant powder revealed various colors under daylight, long UV, and short UV light, depending on the solvent used. The antioxidant properties of the Lepidagathis pungens Nees extracts were assessed through their product scavenges superoxide radicals, hydroxyl radicals, and lipid peroxidations. An aqueous and methanol extract demonstrated the highest scavenging activities across all concentrations for both Lipid peroxidation and hydroxyl radicals. The scavenging activity increased in an inverse relationship between dose and response. In conclusion, this study demonstrated the potential of Lepidagathis pungens Nees as a source of antioxidant compounds, particularly in methanol and aqueous extracts. The safety profile and presence of essential inorganic elements in the plant suggest its potential for use in traditional medicine or as a dietary supplement. Further research into the Inhibitors of antioxidant activity: specific compounds could lead to the development of health-promoting products or therapeutic interventions utilizing the extracts' antioxidant properties.