bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Obesity on Endometrial Cancer: A Comprehensive Analysis
Authors: Kolano Agata , Pejas Anna , Markowiak Szymon , Wardęszkiewicz Marta , Jabłońska Wiktoria , Kasprzak Amelia , Świercz Maciej , Truchta Monika , Mańkowska Aleksandra 
Published: January 2024

Introduction and purpose: Endometrial cancer [EC] is the most common gynecological cancer in developed countries and its incidence is increasing worldwide. Obesity is a prominent risk factor associated with its incidence and progression.
The aim of study: The article aims to provide a thorough explanation of the mechanisms through which obesity can contribute to the development of EC. Additionally, it emphasizes the crucial role of combating excess adipose tissue as a significant component of cancer prevention specifically targeting endometrial cancer.
Material and method: ​​The literature review applied standard criteria and focused on PubMed articles using keywords: Endometrial cancer, Obesity, Mortality, Prevention, Pathogenesis
Description of the State of Knowledge: Obesity significantly impacts EC development and prognosis, particularly in Type I cases. It modifies adipose tissue metabolism, affecting the release of various substances linked to tumor growth and mortality risk.The relative risks escalate with increasing BMI. Following an EC diagnosis, higher BMI, especially ≥40, significantly associates with increased overall mortality risk. On a preventive front,
exercise showcases its potential in reducing EC risk by moderating insulin and estrogen levels.
Summary: These findings underscore the critical role of obesity in both EC development and prognosis, emphasizing the potential for preventive measures. Without proactive measures, the worldwide obesity epidemic will persist, exerting a substantial effect on EC occurrences.
Family-centred empowerment using telenursing on pressure injury incidence in post-discharge stroke patients
Authors: Fashaei Fatemah , Deldar Kolsoum , Froutan Razieh , Mazlom Seyed Reza 
Published: January 2024

Objective: The aim of this study was to evaluate the effect of a family-centred empowerment intervention on the incidence, stage and status of pressure injury (PI) in patients diagnosed with stroke during the post-discharge period with a telenursing approach. Method: This randomised controlled clinical trial (RCT) was conducted with patients admitted to Ghaem Hospital in Mashhad and who were diagnosed with stroke. Patients were randomly assigned to one of two equal-sized groups: intervention and control. Family education and follow-up of the intervention group was performed using WhatsApp messenger for one month. Caregivers of patients in the control group received the routine training programme. The incidence, stage and status of PIs of both groups were measured at the beginning and at one month later using the Braden Scale, the EPUAP/NPUAP Classification System, and the Pressure Ulcer Scale for Healing (PUSH). Results: A total of 60 patients took part in the RCT (30 patients allocated to each group). The incidence of PI in the control group was significantly higher than in the intervention group (p<0.001). The results showed significantly lower stages of PI in the intervention group than in the control group (p<0.001 and p<0.05 for univariable and multivariable models, respectively). The results showed a significantly lower PUSH score in the intervention group than in the control group (p<0.001 and p<0.05 for univariable and multivariable models, respectively). Conclusion: The findings of this RCT show that the empowerment and training of caregivers of patients diagnosed with stroke after discharge using telenursing can reduce the incidence and severity of PIs and improve their status in these patients.
Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma
Authors: Sun Sha-Sha , Guo Xiao-Di , Li Wen-Dong , Chen Jing-Long 
Published: January 2024

BACKGROUND
Recently, combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma (HCC). However, research on triple therapy [lenvatinib + sintilimab + transarterial chemoembolization (TACE)] as a first-line treatment for advanced HCC is limited.
AIM
To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced HCC.
METHODS
HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were enrolled. All patients were treated with lenvatinib every day and sintilimab once every 3 wk. Moreover, TACE was performed every 4-6 wk if necessary. The primary outcome of the study was overall survival (OS). The secondary outcomes were the objective response rate (ORR), disease control rate (DCR), and incidence of adverse events.
RESULTS
Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January 2022. With a median follow-up of 8.5 months, the 3-, 6-, and 12-mo OS rates were 100%, 88.5%, and 22.5%, respectively. The ORR and DCR were 45% and 90%, respectively. The median progressive free survival and median OS were not reached. Common complications were observed in 76% of the patients (grade 3, 15%; grade 4, 2.5%).
CONCLUSION
Combination therapy comprising lenvatinib, sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.
Timing theory integrated nursing combined behavior change integrated theory of nursing on primiparous influence
Authors: He Yan-Xia , Lv Yang , Lan Ting-Ting , Deng Fang , Zhang Yuan-Yuan 
Published: January 2024

BACKGROUND
The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for primipara. This has the potential to enhance the psychological well-being and overall quality of life for primipara, while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and postpartum.
AIM
To explore the effect of timing theory combined with behavior change on self-efficacy, negative emotions and quality of life in patients with primipara.
METHODS
A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May 2022. These cases were divided into two groups, namely the observation group and the control group, with 40 cases in each group. The nursing interventions differed between the two groups, with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior change. The study aimed to compare the pre- and post-nursing scores of Chinese Perceived Stress Scale (CPSS), Edinburgh Postpartum Depression Scale (EPDS), Self-rating Anxiety Scale (SAS), breast milk knowledge, self-efficacy, and SF-36 quality of life in both groups.
RESULTS
After nursing, the CPSS, EPDS, and SAS scores of the two groups was significantly lower than that before nursing, and the CPSS, EPDS, and SAS scores of the observation group was significantly lower than that of the control group (P = 0.002, P = 0.011, and P = 0.001 respectively). After nursing, the breastfeeding knowledge mastery, self-efficacy, and SF-36 quality of life scores was significantly higher than that before nursing, and the breastfeeding knowledge mastery (P = 0.013), self-efficacy (P = 0.008), and SF-36 quality of life (P = 0.011) scores of the observation group was significantly higher than that of the control group.
CONCLUSION
The integration of timing theory and behavior change integrated theory has been found to be an effective approach in alleviating negative mood and stress experienced by primipara individuals, while also enhancing their self-efficacy and overall quality of life. This study focuses on the key concepts of timing theory, behavior change, primipara individuals, negative mood, and quality of life.
Impact of continuous care on cardiac function in patients with lung cancer complicated by coronary heart disease
Authors: Gao Ting , Luo Jin-Lan , Guo Pan , Hu Xi-Wen , Wei Xiao-Yan , Hu Yan 
Published: January 2024

BACKGROUND
Despite sharing similar pathogenic factors, cancer and coronary heart disease (CHD) occur in comparable populations at similar ages and possess similar susceptibility factors. Consequently, it is increasingly commonplace for patients to experience the simultaneous occurrence of cancer and CHD, a trend that is steadily rising.
AIM
To determine the impacts of continuing care on lung cancer patients with CHD following percutaneous coronary intervention (PCI).
METHODS
There were 94 lung cancer patients with CHD following PCI who were randomly assigned to the intervention group (n = 38) and the control group (n = 41). In the intervention group, continuing care was provided, while in the control group, routine care was provided. An evaluation of cardiac and pulmonary function, medication compliance, a 6-min walk test, and patient quality of life was performed.
RESULTS
Differences between the two groups were significant in left ventricular ejection fraction, 6-min walk test, oxygen uptake, quality of life and medication compliance (P < 0.05). In comparison with the control group, the enhancement in the intervention group was more significant. The intervention group had more patients with high medication compliance than the control group, with a statistically significant difference (P < 0.05).
CONCLUSION
After undergoing PCI, lung patients with CHD could benefit from continued care in terms of cardiac and pulmonary function, medications compliance, and quality of life.
Use of cognitive-behavioral career coaching to reduce work anxiety and depression in public employees
Authors: Otu Mkpoikanke Sunday , Sefotho Maximus Monaheng 
Published: January 2024

BACKGROUND
Public employees worldwide are increasingly concerned about work anxiety and depression. Cognitive-behavioral career coaching has emerged as a promising strategy for addressing these mental health disorders, which can negatively impact on a person's overall well-being and performance.
AIM
To examine whether cognitive-behavioral career coaching reduces work anxiety and depression among Nigerian public employees.
METHODS
A total of 120 public employees (n = 60) suffering from severe anxiety and depression were randomly assigned to the treatment or control groups in this study. Cognitive behavioral coaching was provided twice a week to those in the treatment group, whereas no treatment was given to those in the control group. As part of the study, the Hamilton Anxiety Rating Scales and Beck Depression Inventory were used to collect data.
RESULTS
Analysis of covariance of the data from participants indicates a significant effect of cognitive-behavioral career coaching on work anxiety and depression.
CONCLUSION
Insights into the underlying mechanisms by which cognitive behavior career coaching exerts its effects have been gained from this study. Also, the study has gathered valuable data that can inform future practice and guide the development of strategies for supporting mental health at work.
Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation: A case report
Authors: Kohara Saeko , Kamijo Yoshito , Kyan Ryoko , Okada Ichiro , Hasegawa Eiju , Yamada Soichiro , Imai Koichi , Kaizaki-Mitsumoto Asuka , Numazawa Satoshi 
Published: January 2024

BACKGROUND
Most species of aconite contain highly toxic aconitines, the oral ingestion of which can be fatal, primarily because they cause ventricular arrhythmias. We describe a case of severe aconite poisoning that was successfully treated through veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
CASE SUMMARY
A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled, “Aconitum japonicum Thunb”. Two hours after arrival, VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and vasopressors. Nine hours after arrival, an electrocardiogram revealed a return to sinus rhythm. The patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5, respectively. On hospital day 15, he was transferred to a psychiatric hospital. The other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS, revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the root. Serum on admission contained 1.50 ng/mL of aconitine. Beyond hospital day 2, neither were detected. Urine on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine, but these rapidly decreased after hospital day 3.
CONCLUSION
The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.
Uniportal video-assisted thoracoscopic fissureless right upper lobe anterior segmentectomy for inflammatory myofibroblastic tumor: A case report
Authors: Ahn Seha , Moon Youngkyu 
Published: January 2024

BACKGROUND
Inflammatory myofibroblastic tumors (IMTs) are exceptionally rare neoplasms with intermediate malignant potential. Surgery is the accepted treatment option, aiming for complete resection with clear margins.
CASE SUMMARY
A 39-year-old woman presented with a growing solitary pulmonary nodule measuring 2.0 cm in the right upper lobe (RUL) of the lung. The patient under-went a RUL anterior segmentectomy using uniportal video-assisted thoracoscopy. A preliminary tissue diagnosis indicated malignancy; however, it was later revised to an IMTs. Due to the absence of a minor fissure between the right upper and middle lobes, an alternative resection approach was necessary. Therefore, we utilized indocyanine green injection to aid in delineating the intersegmental plane. Following an uneventful recovery, the patient was discharged on the third postoperative day. Thereafter, annual chest tomography scans were scheduled to monitor for potential local recurrence.
CONCLUSION
This case underscores the challenges in diagnosing and managing IMTs, showing the importance of accurate pathologic assessments and tailored surgical strategies.
Entre la desconfiança cap al poder polític i l’esperança de la transparència
Authors: Luján Oriol 
Published: January 2024

Ressenya de
Frédéric Monier, Lluís Ferran Toledano, Joan Pubill i Gemma Rubí(eds.), Las sombras de la transparencia: Secreto, corrupción y «Estadoprofundo» en la Europa contemporánea, Granada, Comares, 2022,270 p.
Trends in harmful drug exposure during pregnancy in France between 2013 and 2019: A nationwide cohort study
Authors: Louchet Margaux , Collier Mathis , Beeker Nathanaël , Mandelbrot Laurent , Sibiude Jeanne , Chouchana Laurent , Treluyer Jean Marc 
Published: January 2024

Objective
Describe the trends of exposure to harmful drugs during pregnancy over recent years in France.

Design
Nationwide cohort study.

Setting
The French National administrative health Data System (SNDS).

Population
Pregnancies starting between 2013 and 2019 and outcomes corresponding to live births, medical terminations of pregnancy, and stillbirths.

Methods
Each pregnancy was divided into a preconceptional period of 90 days before conception and three trimesters from conception to birth. Harmful drugs were defined according to their risks to the fetus: teratogenicity or fetotoxicity. Exposure was defined using the critical period during pregnancy for each type of harmful drug: preconceptional period or first trimester for teratogenic drugs and second or third trimesters for fetotoxic drugs.

Main outcome measures
Prevalence of pregnancies exposed to at least one harmful drug.

Results
Among 5,253,284 pregnancies, 204,402 (389 per 10,000) pregnancies were exposed to at least one harmful drug during the critical periods: 48,326 (92 per 10,000) pregnancies were exposed to teratogenic drugs during the preconceptional period or the first trimester, and 155,514 (299 per 10,000) pregnancies were exposed to fetotoxic drugs during the second or third trimesters. Teratogenic drugs were mainly retinoids for topical use (44 per 10,000 pregnancies), antiepileptics (13 per 10,000 pregnancies) and statins (13 per 10,000 pregnancies). Fetotoxic drugs were mainly non-steroidal anti-inflammatory drugs (NSAIDs), for systemic (128 per 10,000 pregnancies) and topical use (122 per 10,000 pregnancies). Exposure to teratogenic drugs decreased from the preconceptional period to the first trimester. Exposure to fetotoxic drugs decreased from the second to the third trimester. Between 2013 and 2019, we found a decrease in harmful drug exposure overall, mainly for topical and systemic NSAIDs and for topical retinoids.

Conclusions
In this nationwide study, about one in 25 pregnancies was exposed to at least one harmful drug, mainly NSAIDs and topical retinoids. Although the prevalence of harmful drug exposure decreased over the study period, NSAID exposure in the second and third trimester remains of concern.
A Importância dos Toantes Sagrados como Ludicidade na Perspectiva da Educação Escolar Infantil Indígena
Authors: Oliveira Geovana de Souza , Oliveira Débora Benício Alves de , Bringel Maricélia Félix Andrade 
Published: January 2024

O presente trabalho trata de uma pesquisa bastante aprofundada sobre o tema: A importância dos Toantes sagrados como lúdico na perspectiva da Educação Infantil nas escolas indígenas. Este é um tema voltado para a compreensão de como ocorrem as metodologias e práticas pedagógicas através dos Toantes indígenas dentro da sala de aula. Sabemos que a cultura indígena é bastante diversificada as práticas culturais dos povos indígenas é bastante diversificada carregam significados místicos que selam a união da Aldeia e de seus povos. Dentre as práticas culturais existe a dança do coco, a dança da palma, a dança do toré dentre outras. Todas essas manifestações são acompanhadas dos tons a qual eles caracterizam como Toantes/ e ou Rituais sagrado. O estudo tem como objetivo investigar as práticas metodológicas de professores em relação aos toantes indígena como forma de ludicidade para alfabetizar crianças, visto que a musicalidade como ferramenta lúdica para a alfabetização infantil é uma das melhores estratégias como prática pedagógica para estabelecer o que está sendo trabalhado de forma descontraída. Contudo, pouco se fala sobre esta metodologia em termos de toantes sagrados indígenas dentro de suas respectivas escolas, ou se ela realmente existe em termos de alfabetização entre as crianças indígenas. As bases legais que constituem a educação escolar indígena são permeadas pela Constituição Federal de 1988, Lei de Diretrizes e Bases da Educação Nacional, resolução de 1999 e Decreto Presidencial de 2004, esse processo legislativo teve como objetivo assegurar e garantir o direito à diferença étnica, ou seja, ensinar os Curumins (crianças) a ler e escrever por meio de toantes sagrados é um método diferenciado que afirma suas identidades, resgata sua cultura e também gera aprendizado.
Glucose metabolism disorders associated with COVID-19: clinical and morphological study
Authors: Karonova T. L. , Mikhailova A. A. , Lagutina D. I. , Vorobeva O. M. , Grigoreva D. O. , Sterkhova K. A. , Malko V. A. , Mikheeva A. G. , Chernikova A. T. , Mitrofanova L. B. , Shlyakhto E. V. 
Published: January 2024

BACKGROUND. Glucose metabolism disorders (GMD) were detected both in acute and in post-COVID, however, its pathogenic aspects remain unclear.AIM. To analyze the occurrence of GMD in post-COVID patients who have had moderate and severe COVID-19 without previously known GMD disorders, and evaluate expression of SARS-CoV-2 proteins and its entry factors in pancreas in acute COVID-19.METHODS. Among 187 hospitalized patients with confirmed COVID-19 141 patients without previously diagnosed GMD underwent follow-up post-COVID visits. The examination for all patients included anthropometric measurement with calculation of BMI, level of HbA1c and fasting plasma glucose, for 106 patients level of insulin and HOMA-IR index was analyzed. For histological examination, pancreas fragments of 20 patients with fatal outcome were selected. Immunohistochemical study was performed with antibodies to SARS-CoV-2, ACE2, DPP4, as well as double-labeled immunofluorescence microscopy (insulin-SARS-CoV-2, insulin-ACE2, insulin-DPP4).RESULTS. Among 141 patients in post-COVID period, 9 (6.3%) had HbA1c or fasting plasma glucose levels that met criteria for diabetes mellitus, 38 (26.9%) — exceeded normal values (WHO), and 84 (59.6%) had GMD according to criteria of the ADA. In post-COVID, patients with GMD had a higher BMI and HOMA-IR index (p=0.001) compared to patients with normal glycemic levels. Only 40.4% of people had HOMA-IR index above 2.7. Patients with GMD had higher level of CRP (p=0.007) and a maximum glucose level (p=0.019) in the acute period. Positive relationship was found between BMI and HOMA index both in acute (p<0.001; r=0.389) and post-COVID (p<0.001; r=0.412) periods, as well as the level of HbA1c in acute period (p=0.019, r=0.202) and in post-COVID (p=0.004, r=0.242).Histological and immunohistochemical studies showed the expression of SARS-CoV-2 proteins in 1.85% [0–15.4] and 11.1% [5.3–14.8] cells of the Langerhans islets in patients who died on the second and third waves, respectively. The expression of ACE2 and DPP4 in the islets of Langerhans did not exceed 0.4% [0–1.7] and 0.5% [0–0.8] of cells, respectively. Double-labeled immunofluorescence microscopy showed co-localization of SARS-CoV-2, ACE2, DPP4 with insulin.CONCLUSION. Post-COVID Glucose metabolism disorders may be explained by direct cytotoxic effect of SARS-COV-2, increased glucose toxicity and insulin resistance because of the acute infection and its complex therapy.
Identification of Gold Mining Vessels based on Classification Algorithms using Sentinel-2 Images
Authors: Pereira Diego Henrique Costa , Gomes Roberto Arnaldo Trancoso , Carvalho Júnior Osmar Abílio de , Guimarães Renato Fontes 
Published: January 2024

Artisanal and small-scale gold mining can occur on land or in riverbeds. However, the activity needs to be supported by a Mining Permit, issued by the Agência Nacional de Mineração, and the appropriate environmental license from the competent environmental agency. The use of images from Sentinel-2 satellites presents itself as a potential tool for identifying gold mining vessels due to the temporal resolution, free imagery, global coverage, and more refined spatial resolution. So, this study aimed to identify gold mining vessels on the Madeira River near Porto Velho city, Rondônia state, located at Brazilian Amazon, in 13 Sentinel-2 images from 2018 to 2021 using the classifiers: Support Vector Machine (SVM), K-Nearest Neighbors (KNN) Random Forest (RF) and Spectral Angle Mapper (SAM). The results showed that machine learning classifiers obtained the best performance, especially the object-oriented SVM classifier, which had the best average F1 score (0.91). In addition, the detection percentage of gold mining vessels originated by this classifier was satisfactory, with only 0 to 4 active gold mining vessels with sediment plumes being omitted per image. Therefore, based on the results obtained, it was concluded that the use of machine learning classifiers proved to be effective in identifying gold mining vessels.