bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of level of Enset (Ensete ventricosum, Musaceae) Production on Food and Nutrition Security: Empirical Evidences from Wolaita and Kembata Tambaro Zones of Southern Ethiopia
Authors: Bassa Zekarias , Ketema Mengistu , Kuma Berhanu , Mehary Abule 
Published: January 2024

Abstract
Enset is the only crop that can define food and nutrition security literally. Enset crop is closely related to food availability, access, use, stability, and nutrient balancing of densely populated communities in Wolaita and Kembata Tembaro zones. The climate smart, adaptive, productive, economical, and socially important Enset crop is the optimal way for ensuring food and nutrition security of communities. Hence, this study aims to estimate the causal effect of the level of Enset Production on farmers’ food and nutritional security in Southern Ethiopia. The survey applied structured and semi structured questionnaires for the collection of cross-sectional data from 374 sampled households in Wolaita and Kembata Tambaro Zones. Generalized Propensity Score (GPS) with multilevel treatment option was applied to deal with the impact evaluation of Production on food and nutrition security. Food and nutrition status of farming communities defined by calorie intake of households. The proxy measure of the level of Enset production was the number of Enset harvested across households in the last twelve months. The GPS method applied followed three estimation procedures such as modelling the conditional distribution of the treatment given the covariates, estimating the conditional expectation of the outcome given the treatment and GPS, and defining the dose response function. The results show that the small holder farmers that actively involved in harvesting Enset for food are significantly associated with increased level of daily energy intake. The implication of the study revealed that through the promotion level of Enset production, it is possible to have increased and balanced the energy intake of households in Southern Ethiopia. The empirical evidences illustrate that higher level of Enset harvesting is an optimal way for sustainable and better level of food and nutritious security for farming communities in southern Ethiopia.
Mechanism of AZDEGDN accelerating the decomposition of nitrocellulose: Insights from reactive molecular simulations
Authors: Zhang Ting , Qin Weihua , Meng Weifeng , Guo Zhuiyue , Cao Weiguo , Lan Yanhua 
Published: January 2024

Abstract
To get better insight into the effect of plasticizer 1,5-diazido-3-oxopentane (AZDEGDN) on the decomposition of nitrocellulose (NC) binders, thermogravimetric (TG) and Reactive forcefield (ReaxFF) simulation were conducted. The decomposition process of NC and NC/AZDEGDN was simulated at different temperatures (1000-3500 K), as well as the reaction path, main products, and decomposition mechanism. The main decomposition products of NC/AZDEGDN by ReaxFF-MD were N2, H2, NH3, H2O, CO2, and NO2, and the main generation pathways were summarized and verified by radial distribution function. The addition of AZDEGDN decreased the activation energy of NC, and accelerated the decomposition of NC. Some molecules and fragments decomposed from AZDEGDN reacted with the intermediates of NC molecular chains, and promoted the decomposition of NC. Meanwhile, NO2 decomposed from NC acted on AZDEGDN molecules to accelerate the decomposition of AZDEGDN. This study provides atomic insights into the decomposition process of NC/AZDEGDN, which may be helpful for further research on the reaction mechanism of energetic fuels.
Automatic placement of cameras in a particle accelerator using a 3D engine and computational optimization
Authors: Cruz N.C. , Rouret M. , Ortigosa E.M. , Ros E. , Garrido J.A. 
Published: January 2024

Abstract
Particle accelerators have high-radiation parts requiring remote maintenance tasks, which involve using cameras generally placed by human experts. This work addresses camera placement through black-box global optimization. This approach allows opting for automated solutions and relieving experts of that responsibility. The formulation of the objective function hides the environment-specific placement constraints and shows domain ones only. The proposed methodology allows the use of regular meta-heuristics for standard black-box box-constrained problems, as it is only necessary to honor the bounds of variables. Accordingly, the optimization algorithm used is the genetic algorithm provided by the Global Optimization Toolbox of MATLAB. The objective function computation relies on the simulation capabilities of the widespread Unity game engine. It brings us an integrated framework for defining the target process to consider and for checking the different proposals visually. Based on this framework, this work reconstructs the virtual reality simulation of a maintenance task in a particle accelerator. The results obtained show that the camera positioning achieved by the proposal for four cameras and one target process outperforms the arrangement defined by a human expert.
Effect of Acupuncture and Moxibustion, Cupping, and Medicated Thread Moxibustion on Sports Injuries
Authors: Shijun Xu , Cong Zeng , Ningmao Jiang , Qixing Liang 
Published: January 2024

Abstract
Objective: We explored the clinical effect of acupuncture and moxibustion therapy, cupping therapy, and Zhuang medicine thread moxibustion therapy on sports pains and injuries to explain this comprehensive therapy’s treatment mechanism from the perspective of traditional Chinese medicine and Zhuang medicine on the mechanism of Qi, blood, and body fluid.
Method: From 65 athletes who experienced sports pains and injuries during track and field and ethnic sports training for university sports events, we selected 32 patients as an observation group for comprehensive treatment with traditional Chinese medicine and Zhuang medicine. The treatment effect was compared with that of the 33-patient control group who received conventional therapy.
Result: The visual analogue scale was used to evaluate pain level, diagnose pain and injury severity, and evaluate efficacy. Comprehensive therapy had excellent efficacy for mild patients, and moderate-to-low intensity training could be performed during recovery. The observation group’s efficacy in delayed onset muscle soreness, mild injury, and severe injury was significantly better than that of the control group (P ≤ 0.05).
Conclusion: Acupuncture and moxibustion and cupping therapy combined with Zhuang medicine thread moxibustion therapy formed an integrated effect of treatment, cleared the veins, eliminated obstacles, unblocked meridians, relieved pain, promoted normal operation of Qi, blood, and body fluid, and restored vitality. Comprehensive therapy has the characteristics of simplicity, controllability, and effectiveness. Compared with conventional treatment, comprehensive therapy more effectively alleviated exercise-induced pain, especially with significant analgesic and rehabilitation effects on exercise-induced injuries. The consistency between the therapeutic effects of comprehensive and conventional therapies explains the unity of traditional Chinese medicine and modern medical principles. The combination of traditional Chinese and Western medicine can effectively treat sports injuries by leveraging their respective advantages, and this is also an effective path for traditional Chinese medicine’s sustainable development.
Correlation of PIK3R1 overexpression with CD73+ FOXP3+ regulatory T cell infiltration and its role in tumor progression and prognosis prediction in gastric cancer
Authors: CHAN HUANG , Yang Xinhua , Zou Bu , Yang Jiaojiao , He Huichan , Li Ting , Ye Zulu , Zhou Dalei , He Caiyun 
Published: January 2024

Abstract
Background
Biomarkers are crucially required to predict the prognosis of patients with gastric cancer (GC) and especially to identify those who may have intrinsic antitumor immune responses to immunotherapeutic strategies.
Methods
The publicly available databases, our cohort and the vitro experiments were used to identify the biological behavior mediated by PIK3R1 overexpression in GC. We evaluated the relationships between PIK3R1 expression levels and immune cell infiltration by immunohistochemistry, mRNA-seq data and single-cell sequencing data. Furthermore, both The Cancer Genome Atlas (TCGA) stomach adenocarcinoma data and cell lines were utilized to detect the function and mechanism of PIK3R1 in GC. Finally, the prognostic value of PIK3R1 was evaluated using an integrated nomogram.
Results
PIK3R1 expression levels were reduced in many human cancers, while they significantly increased in GC. High PIK3R1 expression levels were associated with disease progression and poor overall survival (OS). In vitro experiments, up-regulated PIK3R1 expression promoted the proliferation, invasion, and metastasis of GC cells. Further, PIK3R1 expression was closely correlated with regulatory T cell infiltration and its related biomarkers (such as FOXP3 and CD73). PIK3R1 overexpression was positively correlated with activated TGF-β/SMAD signaling in the TCGA cohort and the GC cell lines. Analysis of single-cell sequencing data demonstrated that PIK3R1 had an increasing trend during the transformation of benign cells into malignant cells and had a synchronous expression pattern with CD73 and several immunosuppressive molecules (such as FOXP3, LAG3, PDL1, GZMB, and GZMK) that play a role in T cell development. An easy-to use nomogram based on PIK3R1 and CD73 expression levels and several clinicopathological factors outperformed TNM staging at prognosis.
Conclusions
These findings inferred that PIK3R1 acts as a prognostic factor to predict the OS of patients with GC and implied the importance of developing novel immunotherapeutic strategies.
Enhancement of ON-Current in Modified TMG Vertical TFET with Split Pockets
Authors: Sivani K. , Harish B. , Kumar Ch. Pavan 
Published: January 2024

Abstract
This paper emphasizes the configuration of an N+ Si pocket overlay in a Vertical Tunnel Field Effect Transistor (VTFET), incorporating a gate-stacking process. In this design, the source pocket is divided into two segments with differing doping concentrations, specifically low and high concentrations. In Tunnel Field Effect Transistors (TFETs), the source pocket plays a vital role in augmenting the ON-state (ION) current. The vertical structure is implemented to alleviate scaling constraints and improve the device's scalability. To address ambipolarity, the gate electrode is divided into three segments with optimal work-functions of 4.15 eV, 4.30 eV, and 4.15 eV for the Auxiliary gate, Control gate, and Tunneling gate, respectively. The sub-threshold slope of short-channel Tunnel Field Effect Transistors (TFETs) will experience enhancement through a gate-stacking procedure employing high-k gate oxides, such as HfO2, in combination with SiO2 in the stack. Additionally, the pocket overlay positioned in the center of the source-channel region, utilizing low band gap group III-V materials, contributes to further improvements in the current ratio (ION / IOFF) and sub-threshold slope. In the presented device, the measured ION current and IOFF current are 8.14 x 10-3 A/μm and 5.37 x 10-11 A/μm, respectively. The threshold voltage is reduced to 0.2V. These achieved parameters establish the N+ Si pocket-doped Triple Metal Gate (TMG) VTFET as well-suited for applications demanding low power consumption.
Poly-ADP-ribosylation of KDM4D induces transcription in the hippocampus and amygdala
Authors: Savchenko Valentina L. 
Published: January 2024

Abstract
Poly-(ADP-ribose) polymerases (PARPs) play a significant role in DNA repair of single or double strand breaks and regulate transcription. PARPs also catalyze the Poly-(ADP)-ribosylation (PARylation) of proteins that are involved in the DNA repair and transcriptase machinery. PARP1 induces Poly-(ADP)-ribosylation of the enzyme lysine (K)–specific demethylase 4D (KDM4D) to modify the histone3 for triggering the transcription. The demethylation of H3K9me2 with KDM4D leads to an expression of transcription factors that are involved in the DNA repair. Thus, in addition to the significance of protein PARylation by PARP1 involved in the damaged DNA repair, the PARylation of KDM4D triggers the transcription in the hippocampus and amygdala.
Homologies between Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens]: a starting point for to deliver drugs to cells?
Authors: Andrade Luís Jesuino de Oliveira , de Oliveira Gabriela Correia Matos , de Oliveira Luisa Correia Matos , de Oliveira Luís Matos 
Published: January 2024

Abstract
Objective
The purpose of this study is to explore the possible homology between the AA sequences of Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens].
Materials and methods
Were performed the comparison with the VectorBuilder online, between the AA sequence of the GenBank: EOX96570 - Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and GenBank: AAH50659.1 - PEG10 protein [Homo sapiens], using databanks of proteins from the National Center for Biotechnology Information (NCBI). The predicted structure of the GenBank: EOX96570 was used to design molecule that could target other proteins. The molecule was designed using a combination of EOX96570 with tyrosine kinase inhibitor (2X9F - ephB4 kinase domain inhibitor complex), accessed in the RCSB PDB database, by molecular docking and molecular dynamics simulations by SwissDock.
Results
The homology between the Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens], presented an identity of 51.72% (45/87) and a similarity of 51.72% ( 45/87). A molecule was designed using a combination of EOX96570 with a tyrosine kinase inhibitor (2X9F - EphB4 kinase domain inhibitor complex) through molecular docking and molecular dynamics simulations. The EOX96570 and the tyrosine kinase inhibitor were docked into the active site of the EphB4 kinase domain, taking into consideration their binding affinities and structural compatibility.
Conclusion
Bioinformatics data, suggest a possible link between Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens], and studies on the fruit of the cocoa tree are important to the safe, effective development of pharmaceutical products for the deliver drugs to cells.
Productivity and profitability of Wheat cropping system in southeastern Ethiopia
Authors: Dinsa Girma F. , Bogale Mengistu 
Published: January 2024

Abstract
As demand for food is rising, yield is expected to double to feed the 9 billion people in 2050. However, climate change is posing a pressing threat to sustainable food production for the increasing population. Wheat is a strategic crop for food security, and increasing its productivity is vital to ensuring food sufficiency. The dominant cropping system in the southeast Ethiopian highlands is wheat monocropping, which is constrained by the prevalence of yield-reducing factors such as diseases, pests and weeds. We evaluated combinations of crop management options to determine system productivity and profitability for sustainable wheat production. The production factors included in the treatment combinations were tillage type, crop rotation, and weed management options; these factors were applied during alternating (2007, 2009 and 2011) seasons, followed by the main crop (wheat) in the next season (2008, 2010 and 2012). Analysis of variance was performed for yield, weed population and economic parameters and revealed the significant effects of the management factors on wheat yield, weed population density and system profitability. A greater yield was obtained from fallow-retention followed by dry tillage and faba bean rotation. The weed population density was lower in the faba bean and rape seed rotations. All the broad leaf weed species were less than 25%, except for the Galium species, and all the grassy weeds were less than 30%, except for Cyprus species, in both the faba bean and rape seed rotation systems. In addition, Bromus pectinatus and Avena fatua were effectively controlled by rape seed and faba bean rotation, respectively, in the bread wheat production system. Rape seed rotation was the most profitable weed management option for bread wheat production, with a net benefit of 44,559 Ethiopian Birr (ETB)/ha and a net marginal return of 790 ETB/ha, which ensures that farmers receive an additional return of 6.90 ETB from each 1 ETB invested in the rape seed-wheat production system.
Antropónimos-topónimos y las disputas sobre el territorio en la cuenca media del Usumacinta durante el periodo Clásico Temprano
Authors: García Juárez Sara Isabel 
Published: January 2024

El presente artículo aborda el estudio de las formas de organización política maya durante el periodo Clásico Temprano en la cuenca media del Usumacinta a través del análisis epigráfico de los dinteles 60, 49, 37 y 35 de Yaxchilán. Derivado del estudio de estos cuatro monumentos, que forman una sola unidad narrativa, se explora la importancia de los antropónimos-topónimos en la reconstrucción histórica de procesos políticos, territoriales y sociales en la región. En dichos dinteles se encuentran registrados antropónimos-topónimos conformados por la expresión waklaju’un pet, ‘dieciséis pet[enes] (provincias)’, que son significativos por indicar, de manera indirecta, que algunas poblaciones estaban integradas por petenes (provincias), antes de que se consolidaran como “señoríos” (ajawlel). Los nombres de personas (antropónimos), que tienen integrados nombres de lugares (topónimos), aparecen en registros jeroglíficos de los periodos Clásico Tardío y Clásico Terminal y permiten dimensionar la profunda relación que existe entre los antropónimos, las designaciones de los territorios y los nombres de familia. Las evidencias más importantes que indican que la integración territorial de los señoríos, estructurados en “dieciséis provincias”, fue un fenómeno de larga duración (hasta el periodo Posclásico, en Mayapán) es la presencia de los términos waklaju’un oon, ‘dieciséis familias’ y waklaju’un ajaw, ‘dieciséis señores’, en las inscripciones del periodo Clásico, así como la evidencia de la existencia de dieciséis cuchcabaloob en Mayapán. La razón por la cual los mayas habrían concebido la estructura del ajawlel en dieciséis provincias – dieciséis familias habría respondido a una lógica armónica cuatripartita, direccional y cromática, con cuatro petenes en cada rumbo cósmico.
Chloroplast Small Heat Shock Protein CsHSP24.6 of Tea Plants Positively Regulates Heat, Light, and Salt Stress Tolerance
Authors: Wang Haiyan , Ma Jing , Han Xueying , Zhu Mengqing , Luo Yuanyuan , Chen Yifan , Fu Zhouping , Ma Guoliang , Gao Liping , Xia Tao 
Published: January 2024

Small heat shock proteins (sHSPs) function as molecular chaperones,
which play crucial roles in plant growth, development, and stress
response. However, the function of the sHSP gene in the tea plant
(Camellia sinensis L.) has not been extensively investigated. In total,
54 C. Sinensis small heat shock proteins (CssHSPs) in the tea plant
genome were screened. Phylogenetic analysis revealed that CssHSPs in the
same group have similar conserved domains and motifs; conversely,
significant structural differences exist in the different groups. Most
CssHSP genes had tissue-specific expression. They also responded to one
or more abiotic or biotic stresses, CsHSP24.6 was selected for
functional analysis. The results demonstrated that the expression of
CsHSP24.6 increased under abiotic stresses such as temperature, light
intensity, and NaCl. In addition, under high temperature and high light
intensity treatments, CsHSP24.6 and its target gene CspTAC5 interacted
to enhance the heat and light resistances of the plant. CsHSP24.6
facilitates resistance to abiotic stresses in tea plants. These results
further support that CsHSP24.6 plays an essential role in maintaining
plant growth and development under abiotic stress.
Single sIgE for Dermatophagoides pteronyssinus ( Dp ) is a good screening tool for atopic sensitization
Authors: Lam Ki , Tung Edmund Kwok-Kwan , Ho Marco HK , Wong Wai-Yu , WK Ip , Au Elaine 
Published: January 2024

Background: Only a limited number of publications had evaluated
the Phadiatop application for aeroallergen screen in allergic
respiratory diseases (ARD) in the Chinese population. In our
retrospective cohort, through studying the Phadiatop versus total IgE
use in aeroallergen workups, and local aeroallergen sensitisation
profiles by reviewing aeroallergen sIgE, we aimed to derive a
cost-effective algorithm for ARD workup. Methods: We have
retrospectively identified 694 patients with ARD in 2010-2019, and
reviewed their Phadiatop test performed in our tertiary immunology
laboratory. Other associated workups including total IgE, and/or
allergen specific sIgE (sIgE), if available, were retrieved and
analysed. Besides, a further review was performed on 53 consecutive
samples collected during January 2021, for aeroallergen screening. Cost
effectiveness of the existing protocol (Phadiatop screening followed by
individual aeroallergen characterisation) was compared with a new
testing algorithm, which started with dust mite ( Dermatophagoides
pteronyssinus, Dp) allergy detection. Results: Phadiatop
positivity was 67.3%, while total IgE positivity was 66.7% in the 366
patients with the test done. Overall, the agreement of these two tests
was 73.5%. Asthmatic patients can be screened positive with total IgE
than Phadiatop (34.9%-45.6%). Dp was the most prevalent aeroallergen
(> 90%), and its sIgE level correlated best with the
Phadiatop sIgE level (R = 0.99, p < 0.001). Comparing to the
existing screening using Phadiatop, initial Dp detection is both
sensitive and cost effective for ARD in our locality.
Conclusions: Screening by Dp sIgE is as sensitive as Phadiatop
in aeroallergen screen but of lower running cost. It should be the
approach in our locality.