bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Diffusion Tensor Imaging and Neurite Dispersion and Density Imaging in Isocitrate Dehydrogenase-Mutant Grade 2 and 3 Gliomas: Definition of Tumor-Related Epilepsy and Predictive Factors of Seizure Outcomes Based on a Single-Center Retrospective Case Series
Authors: Bono Beatrice C. , Grimi Alessandro , Di Toro Artem Emanuele , Ninatti Gaia , Franzini Andrea , Rossini Zefferino , Tropeano Maria Pia , Navarria Pierina , Bellu Luisa , Simonelli Matteo , Dipasquale Angelo , Savini Giovanni , Levi Riccardo , Politi Letterio S. , Pessina Federico , Riva Marco 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Understanding and managing seizure activity is crucial in neuro-oncology, especially for highly epileptogenic lesions like isocitrate dehydrogenase (IDH)-mutant gliomas. Advanced MRI techniques such as diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) have been used to describe microstructural changes associated with epilepsy. However, their role in tumor-related epilepsy (TRE) remains unclear. This study aims to investigate the role of DTI and NODDI tumor-derived metrics in defining TRE and predicting postoperative seizure outcomes in patients undergoing surgical resection for IDH-mutant grade 2 and 3 gliomas.

METHODS:
This was a single-center retrospective study. Preoperative DTI parameters included fractional anisotropy and mean diffusivity. NODDI parameters included neurite density index (NDI), orientation dispersion index, and free-water fraction (FWF). These metrics were calculated within three volumes of interest (fluid-attenuated inversion recovery [FLAIR] tumor volume, FLAIR peripheral zone, and FLAIR central zone [Fcz]) and correlated with seizure presentation, type, and postoperative control, which was reported according to the Engel classification system.

RESULTS:
Fifty-seven patients were included in this study. Increased NODDI-derived FWF-Fcz (P = .031) and NDI-Fcz (P = .046) values correlated with preoperative generalized seizure presentation, although only the FWF-Fcz confirmed its statistical significance (P = .047) in the multivariate analysis. Lower mean diffusivity-FLAIR tumor volume correlated with poor postoperative seizure control both in the univariate (P = .015, P = .026) and multivariate analyses (P = .024, P = .036), while a trend toward significance was found between higher NDI-FLAIR peripheral zone and worse seizure control (P = .055).

CONCLUSION:
DTI and NODDI tumor-derived quantitative parameters may define TRE and predict postoperative seizure outcomes in patients with IDH-mutant gliomas. Notably, DTI metrics were found to be independent predictors of postoperative seizure outcomes, while preoperative NODDI parameters correlated with seizure presentation. Further research is warranted to validate our findings and to better understand the underlying mechanisms driving TRE.
Dietary fat quantity and composition influence hepatic lipid metabolism and metabolic disease risk in humans
Authors: Srnic Nikola , Westcott Felix , Caney Eleanor , Hodson Leanne 
Published: January 2025

ABSTRACT
The excessive accumulation of intrahepatic triglyceride (IHTG) in the liver is a risk factor for metabolic diseases, including type 2 diabetes and cardiovascular disease. IHTG can excessively accumulate owing to imbalances in the delivery, synthesis, storage and disposal of fat to, in and from the liver. Although obesity is strongly associated with IHTG accumulation, emerging evidence suggests that the composition of dietary fat, in addition to its quantity, plays a role in mediating IHTG accumulation. Evidence from human cross-sectional and interventional studies indicates that diets enriched with saturated fat compared to other fat types and carbohydrates produce divergent effects on IHTG content. However, the mechanistic reasons for these observations remain unknown. Given the challenges of investigating such mechanisms in humans, cellular models are needed that can recapitulate human hepatocyte fatty acid metabolism. Here, we review what is known from human studies about how dietary fat, its quantity and composition contribute to IHTG accumulation. We also explore the effects of fatty acid composition on hepatocellular fat metabolism from data generated in cellular models to help explain the divergences observed in in vivo studies.
SOCIAL PROTECTION IN THE CONTEXT OF CLIMATE CHANGE
Authors: Eyvazova Tutu R. 
Published: January 2025

The article is devoted to the analysis of current social protection measures applied in the context of climate change. The subject of the analysis is the forms of implementation of social protection.
Purpose. The author sets the task of identifying the optimal ways of implementing social protection measures as an important area of social security.
Methodology. The study is based on a systems approach, structural-functional and comparative-historical analysis, as well as general scientific and special scientific methods.
Results. In accordance with climate change, it is proposed to make appropriate changes to social policy in the field of health care and promotion of healthy lifestyles. Disease prevention is based primarily on compliance with the basic provisions of social security, including those related to the ecological environment.
Practical significance. The results of the study can be used in the sphere of socio-political planning and forecasting.
A late diagnosis and treatment of coarctation of aorta six months after presenting with aortic dissection
Authors: Sheedy Maxwell , Cihan Chevik  , Magdiel Trinidad-Hernandez  
Published: January 2025

Coarctation of the aorta (CoA) is a congenital condition causing narrowing of the aorta, typically just after the left subclavian artery. Most patients with CoA are diagnosed at birth or during infancy. However, they can also be undiagnosed later in adulthood with minimal symptoms to show or treatment-resistant hypertension. However, some patients may also present with life-threatening medical emergencies that may lead to an undiagnosed CoA. This case is a 40-year-old man with hypertension who presented with a late diagnosis of CoA on computed tomography imaging six months after ascending aorta dissection repair. The patient's CoA was repaired via an endovascular approach with stent placement and post-dilatory balloon angioplasty. His CoA segmental blood pressure gradient was 25 mmHg and decreased to 3 mmHg post-procedure. The patient has done well post-procedure, and his blood pressure had been within normal limits.
Key words: Aortic coarctation, aortic dissection, hypertension, congenital heart defect
Assessment and management of leg oedema in primary care
Authors: Nazarko Linda 
Published: January 2025

Leg oedema is a common symptom that can be misunderstood and misdiagnosed. It affects an estimated 400,000 people in the UK ( Lymphoedema support network, 2021 ) and around 240,000 of those people have lymphoedema ( House of Commons, 2013 ) Misdiagnoses can lead to unnecessary investigations and treatment that is at best ineffective and worst harmful. This article aims to provide the nurse with information on how to assess, diagnose and manage leg oedema in primary care. Here, Linda Nazarko explains how it can be assessed and managed in a general practice setting
Evaluating Sex Differences in Language Abilities Within Down Syndrome and Autism Spectrum Disorder
Authors: Udhnani Manisha D. , Lee Nancy Raitano 
Published: January 2025

Abstract
Down syndrome (DS) and autism spectrum disorder (ASD) are two neurodevelopmental disorders characterized by impairments in language. Most studies do not consider the possible role sex differences may play in language profiles. Thus, the current study aimed to evaluate whether parent-reported structural and pragmatic language vary as a function of sex in youth with DS (n = 37), ASD (n = 106), and typical development (TD; n = 61). Findings suggest a female advantage in both structural and pragmatic language in DS; in contrast, no sex differences were found for either ASD or TD. Results suggest that males with DS may require more extensive interventions for language. Future research should investigate how age, IQ, and mode of measurement may impact the nature of these observations.
Near-infrared spectroscopy discriminates mass-reared sterile and wild tsetse flies
Authors: Pagabeleguem Soumaïla , Da Dari F. , Somé Bernard M. , Avelessi Marx S. P. , Djègbè Nicaise D. C. , Yoda Rebecca L. , Bagayogo Abdramane , Maïga Hamidou , Churcher Thomas S. , Dabiré Roch K. 
Published: January 2025

Background
Monitoring the efficacy of the sterile insect technique (SIT) programs, it is desirable to discriminate between wild and sterile tsetse males captured in monitoring traps. Currently, this is primarily achieved by marking sterile males with fluorescent dye powder before release, and identifying them using a fluorescence camera and/or microscope. However, the accuracy of this method is limited due to defective marking and wild flies contaminated with a few dye particles in the monitoring traps. Molecular techniques have been developed to discriminate doubtful flies, but they are expensive for endemic countries.

Methodology/Principal findings
Here, we investigate the ability of a new generation monitoring tool, Near-Infrared Spectroscopy (NIRS), to discriminate between laboratory-reared Glossina palpalis gambiensis males and their field counterparts. NIRS was able to discriminate wild males from laboratory-reared males with 86% accuracy. Notably, the prediction accuracy improved to 88% when the laboratory-reared flies had been irradiated.

Conclusions/Significance
These findings suggest that NIRS can successfully identify tsetse flies even when UV camera identification is inconclusive. However, further studies are needed to expand the training dataset and include additional environmental variables before validating NIRS as a complementary method for future tsetse eradication programs.
Anxiety among cancer patients: A cross-sectional study at The University of Gondar comprehensive specialized hospital
Authors: Aragie Hailu , Adugna Dagnew Getnet , Baye Nega Dagnew , Negash Habtu Kifle 
Published: January 2025

Introduction
Anxiety is a prevalent psychological issue among cancer patients, significantly affecting their quality of life and potentially influencing treatment outcomes. This study aims to investigate the prevalence and associated factors of anxiety among cancer patients at the University of Gondar Comprehensive Specialized Hospital in Northwest Ethiopia.

Methods
A cross-sectional study design was used, involving 384 cancer patients, selected by systematic random sampling technique, from the oncology ward. Data were collected using the Generalized Anxiety Disorder 7-item (GAD-7) scale and the Oslo Social Support Scale (OSS-3). Descriptive and inferential statistics, including bi-variable and multi-variable logistic regression analyses, were employed to analyze the data.

Results
The prevalence of anxiety was 88.3%, with 34.4% of patients experiencing severe anxiety, 29.2% moderate anxiety, and 24.7% mild anxiety. Significant predictors of anxiety included participants age>= 61years (AOR =  2.99, 95% CI =  1.31–6.79), participants age 30-60 years (AOR =  4.13, 95% CI =  1.53–11.07), female sex (AOR =  2.04, 95% CI =  1.02–4.07), advanced cancer stage (AOR =  3.08, 95% CI =  1.11–8.53), and ongoing treatment (AOR =  2.40, 95% CI =  1.14–5.10).

Conclusion
The study found a high prevalence of anxiety among cancer patients, compared to the previous studies, highlighting the need for integrated psycho-oncology services. Specific interventions are necessary for high-risk groups, including older patients, females, and those with advanced-stage cancer.
Exploring the relationship between established HIV risk factors and depressive symptoms amongst young women without HIV in two sites in South Africa
Authors: Gumbi Zanenhlanhla , Mehou-Loko Celia , Masson Lindi , Mdladla Makhosazana , Maphumulo Nokuthula , Passmore Jo-Ann , Mbeje Sanele , Bekker Linda Gail , Potloane Disebo , Jaspan Heather , Radzey Nina , Abrahams Andrea , Harryparsad Rushil , Mkhize Pamela , Humphries Hilton 
Published: January 2025

Purpose
Adolescent girls are at high risk for depression and human immunodeficiency virus (HIV) acquisition. Poor mental health can increase vulnerability to risky sexual behaviours. Therefore, this study aims to determine the prevalence of depressive symptomology and explore the convergence of HIV risk factors with depressive symptoms amongst cis-gender adolescent girls and young women (AGYW) in rural KwaZulu-Natal (KZN) and peri-urban Western Cape (WC) communities in South Africa.

Methods
Cross-sectional survey data from two sites in South Africa was used - the rural Vulindlela community in KZN and the peri-urban Philippi East community in the WC. Study inclusion criteria included being sexually active with at least one male partner, and not planning to relocate in the next 12 months. The PHQ-9 scale was used to determine depressive symptomology, a socio-behavioural questionnaire was used to determine sexual behaviours, odds ratios and confidence intervals derived from logistic regression models were used to explore the associations between depressive symptomology and socio-behavioural factors associated with HIV acquisition.

Results
The cohort consisted of 274 adolescent girls, 38.6% from the WC site and 61.4% from the KZN site. Overall, 15.7% (43/274) of AGYW reported depressive symptoms. Participants from the peri-urban WC site were more likely to experience depressive symptoms (OR 8.34; 95% CI 3.80–18.30) compared to those living in the rural KZN site. Depressive symptoms were less likely to occur in adolescent girls between the ages of 14 to 17 as compared to those between the ages of 18 and 19 (OR 0.44; 95% CI 0.22–0.90). Socio-behavioural HIV risk factors associated with depressive symptoms include: age disparate relationships (OR 2.98; 95% CI 1.52–5.84), high (four or more) numbers of lifetime partners (OR 8.15; 95% CI 3.60–18.45) and engaging in sex under the influence of alcohol (OR 2.58; 95% CI 1.32–5.04). Multivariate analysis showed that participants from the WC site (AOR 5.25; 95% CI 1.95–14.17) had higher odds of experiencing depressive symptoms while participants with four or more lifetime partners (AOR 3.46; 95% CI 1.24–9.60) were at higher odds of experiencing depressive symptoms.

Conclusion
In this cross-sectional study, depressive symptomology is associated with certain HIV risk behaviours. Longitudinal studies are required to test the causal relationship between depression and HIV acquisition and to better understand the geospatial differences observed.
Ready Reader One: The Stories We Tell With, About, and Around Videogames, Megan Amber Condis and Mike Sell (eds) (2024)
Authors: Alberto Maria K. 
Published: January 2025

Review of: Ready Reader One: The Stories We Tell With, About, and Around Videogames, Megan Amber Condis and Mike Sell (eds) (2024)
Baton Rouge, LA: Louisiana State University Press, 344 pp.,
ISBN 978-0-80718-230-7, p/bk, USD 35.00
Not All Fun and Games: Videogame Labour, Project-based Workplaces, and the New Citizenship at Work, Marie-Josée Legault and Johanna Weststar (2024)
Authors: Johnson Matthew S. S. 
Published: January 2025

Review of: Not All Fun and Games: Videogame Labour, Project-based Workplaces, and the New Citizenship at Work, Marie-Josée Legault and Johanna Weststar (2024)
Montreal: Concordia University Press, 377 pp.,
ISBN 978-1-98811-149-0, p/bk, CAD $59.95
Comparative Improvement in Health-Related Quality of Life with Advanced Therapies for Moderate-to-Severe Crohn’s Disease: A Network Meta-Analysis
Authors: Olivera Pablo A. , Parks María L. , Zubiaurre Ignacio , Peyrin-Biroulet Laurent , Lasa Juan S. , Targownik Laura E. 
Published: January 2025

Background and Aims:
The comparative efficacy of advanced therapies to improve health-related quality of life (HR-QoL) in Crohn’s disease (CD) is unknown. We aimed to compare the impact of approved advanced therapies for moderate-to-severe CD on HR-QoL.

Methods:
We searched MEDLINE, Embase, and Cochrane CENTRAL from inception to December 2023. We included randomized controlled trials (RCTs) that assessed approved advanced therapies for the treatment of adults with moderate-to-severe luminal CD. The primary outcome was change from baseline in the Inflammatory Bowel Disease Questionnaire (IBDQ). Pairwise random-effects meta-analyses were conducted, and we reported results as mean differences (MD) for continuous outcomes and risk ratios for binary outcomes, with corresponding 95% confidence intervals (CI). A random-effects frequentist network meta-analysis was conducted, and the competing interventions were ranked using the P-score.

Results:
Our search strategy 34 records that fulfilled our eligibility criteria. In pairwise meta-analysis, advanced therapies were associated with improvements in IBDQ score (MD 16.07, 95% CI 12.59 – 19.54) after induction. In network meta-analysis, upadacitinib 45mg ranked first for change in IBDQ after induction (MD 23.10, 95% CI 14.41 – 31.78, P-score 0.86). For maintenance studies, advanced therapies showed a significant improvement in IBDQ score in pairwise meta-analysis (MD 12.72, 95% CI 10.47 – 14.97). Infliximab 10mg/kg ranked first for change in IBDQ after maintenance (MD 24.91, 95% CI 12.99 – 36.83, P-score 0.90).

Conclusion:
Advanced therapies were associated with improvements in HR-QoL after induction and maintenance. Upadacitinib 45mg and infliximab 10mg/kg ranked highest after induction and maintenance, respectively.
ANALISIS FAKTOR FAKTOR YANG MEMPENGARUHI KINERJA KEUANGAN BANK UMUM DI INDONESIA (Studi Kasus Pada Bank Umum Dengan Total	Assets Kurang Dari 1 Triliun)
Authors: Mawardi Wisnu 
Published: January 2025

Penelitian dari Biro Riset lnfobank menganalisis pengaruh efsisiensi operasi (BOPO), resiko kredit ( NPL), resiko pasar ( NIM), modal ( CAR) terhadap kinerja keuangan ( ROA), bahwa bank umum dengan total assets kurang dari 1 triliun mempunyai kinerja keuangan yang lebih baik dibandingkan dengan bank umum dengan total assets 1 triliun atau lebih. Data yang diambil dari Direktorat Perbankan Indonesia dan dari Biro Riset lnfobank Hasil penelitian menunjukkan bahwa ada pengaruh negatif dan signifikan resiko kredit ( NPL) terhadap kinerja keuangan (ROA), pengaruh positif dan signifikan resiko pasar (NIM) terhadap kinerja keuangan (ROA) serta berpengaruh negatif dan signifikan resiko pasar (NIM) terhadap kinerja keuangan ( ROA), dan Tidak berpengaruh modal ( CAR) terhadap kinerja keuangan ( ROA)
PENGARUH TINGKAT DESENTRALISASI DAN STRATEGI MANAJERIAL TERHADAP HUBUNGAN ANTARA PENGGUNAAN ANGGARAN DENGAN PENINGKATAN KINERJA MANAJERIAL
Authors: Sjahrial Dermawan 
Published: January 2025

This study investigates the influence of managerial strategic on the relationship between budgeting design usage and managerial performance. The objectives of this study are : (1) to investigate the relationship between budgeting design usage and managerial performance and (2) to investigate the relationship between budgeting design usage and managerial performance differs depending on the degree of decentralization. (3) to investigate the effect of managerial strategic in the relationship between budgeting design usage and managerial performance. (4)) to investigate the effect of managerial strategic on the relationship between budgeting design usage and managerial performance differs depending on the degree of decentralization. The expectations in the model were explored with data gathered from 26 public banks in Bursa Efek Jakarta. The study uses a research methodology survey method supplemented by questionnaire, the survey questionnaire is adapted from previous studies. The respondents of the survey questionnaire were Chief Executive Officers and Middle Managers responsible for unit budgets in the sample of companies. The result of the study are : (1) there is a significant relationship between budgeting design ugase and managerial performance. (2) There is a significant relationship between budgeting design usage and managerial performance differs depending onteh degree of decentralization. (3) there is a significant relationship between budgeting design usage and managerial performance is moderated by managerial strategic. (4) The moderating effect of managerial strategic on the relationship between budgeting design usage and managerial performance differs depending on the degree of decentralization.
ANALISIS PRODUKSI DAN HARGA IKAN KEMBUNG (Rastrelliger Sp) DI TEMPAT PELELANGAN IKAN PELABUHAN PERIKANAN NUSANTARA BRONDONG KABUPATEN LAMONGAN
Authors: Bambang Azis Nur 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pola produksi, jumlah produksi dan nilai produksi, serta faktor faktor yang mempengaruhi harga ikan kembung dalam pelelangan di TPI PPN Brondong Lamongan Dalam penelitian ini digunakan metode studi kasus. Alat analisis yang digunakan dalam penelitian ini adalah (1) statistik diskriptif dan (2) Statistik parametrik. Model regresi untuk penelitian ini dihipotesiskan sebagai berikut: HRGKB = f (PRODKB, PRODLY, Ceteris Paribus) Hasil riset menunjukkan bahwa pola produksi ikan kembung berfluktuatif, disebabkan oleh adanya pengaruh musim ikan. Jumlah produksi terbanyak pada waktu puncak musim (Agustus)dan terendah pada musim sepi (Maret). Hasil analisis regresi didapatkan dua variabel yang mempengaruhi harga ikan kembung, yaitu jumlah produksi dan harga ikan pengganti dengan persamaan HRGKB = 2371.35-0,946 PRODKB + 0,007 HRGLY. Koefisien PRODKB bernilai minus, berarti jika produksi kembung meningkat, maka harga ikan kembung akan mengalami penurunan, demikian sebaliknya.
OBSERVASI PADA PERILAKU PENJUAL, PEMBELI DAN APARAT DINAS PADA PASAR TRADISIONAL MEMOTRET CIRI KULTURAL PELAKU BISNIS DAN PENGUASA KITA
Authors: Widiatmo Riasto 
Published: January 2025

Berangkat dari kesenjangan antara pengajar atau pelatih atau nara-sumber pada Pelatihan bagi usaha mikro, usaha kecil dan KOPERASI dengan para peserta kursus, pelatihan atau pembinaan usaha mikro, usaha kecil dan KOPERASI. Masalah tersebut berawal dari keterbatasan kemampuan pengajar yang biasanya berangkat dari buku atau literatur dan sama sekali tidak mengenal realita yang terjadi dan fakta yang sudah menjadi kultur manajemen dan marketing para pengusaha mikro, pengusaha kecil dan KOPERASI.Materi MANAJEMEN dan MARKETING yang diberikan pasti sama dari waktu kewaktu. Manajemen selalu menampilkan bahan-bahan tentang fungsi-fungsi manajemen : planning, organizing, actuating dan controling sedangkan marketing selalu menyajikan masalah promotion, price, place dan product.Pengafar dari Perguruan Tinggl yang dikatakan lebih hebat semakin jauh dari realitas karena lebih mengutamakan mengamb/1 sumber-sumber terbaru dan mutakhir dari jurnal manafemen terbaru yang berasa/ dari negara-negara maju yang kondisi dan keadaannya sangat jauh berbeda. Akhirnya tujuanakhir dari penyelenggaraan pelatihan dan pembinaan bagi usaha mikro, usaha kecil dan KOPERASI akan jauh dari harapan. Para peserta hanya mengantuk dan pulang dengan bingung karena bahan yang diperoleh tidak (J1ungkin diterapkan pada usahanya.Untuk menjembatani masalah “jurang" antara pengajar UKM dengan UKM maka observasi sosiologi-ekonomi ini berusaha memulai pembahasan manajemen dan marketing UKM dengan memotret realita manajemen yang ada di pasar tradisional. Metode observasi sosiologis yang berusaha memotret fakta, menjadikan pasar tradisional sebagai laboratorium manajemen. Ahli sosio/ogi menjadikan kota sebagai laboratorium. Cara memotret fakta dengan metode sosiologis memang berbeda dengan penelitian yang dilakukan oleh disiplin ilmu manajemen yang menganggap bahwa a/at analisis statistik yang rumit dianggap lebih canggih padahal a/at analisis statistik justru memerlukan banyak sekali penyederhanaan. Selanjutnya apalah arti dan manfaat sebuah perencanaan strategis jika semua berawal dari suatu penyederhanaan. Observasi sosiologi-ekonomi pada tu/isan ini mengambil obyek PASAR TRADISIONAL