bluuebunny/crossref_metadata_2025_split huggingface dataset:
The primary geology of the Paleoproterozoic Mt Weld Carbonatite Complex, Western Australia
Authors: Chandler Ross , Bhat Ganesh , Mavrogenes John , Knell Brad , David Rhiannon , Leggo Thomas 
Published: February 2024

Abstract
The paleoregolith overlying the c. 2.06 Ga Mt Weld carbonatite (eastern Yilgarn Craton, Western Australia) hosts one of the largest Rare Earth Element (REE) deposits globally. Historic exploration and research has focussed on this weathered material, with a lack of unweathered samples preventing a thorough investigation into the nature of the underlying carbonatite. Recent deep drilling has allowed this first in-depth study into the primary geology, mineralogy and geochemistry of the carbonatite complex. Mt Weld shares a similar lithological architecture to other global carbonatite complexes, such as Ngualla (Tanzania, Bonga (Angola), Chilwa Island (Malawi) and Mirima Hill (Malawi), displaying a central (~600 m diameter) unit of magnesio- to ferrocarbonatite is surrounded by a broad (~1.2 km) annulus of calciocarbonatite, itself surrounded by a fenitic halo. Primary REE mineralisation occurs within the central magnesio- to ferrocarbonatites (~2% Total Rare Earth Oxides in bulk rock) and is dominated by fine-grained monazite hosted within fractures and voids, as well as late magmatic synchysite/bastnäsite. Both high and low phosphourous ferrocarbonatites occur within this central magnesio- to ferrocarbonatite unit that display (respectively) monazite or synchysite/bastnäsite mineralisation with textural evidence for these REE-bearing carbonates occasionally forming as polycrystalline pseudomorphs of earlier burbankite group minerals. Magnesio- to ferrocarbonatite dykes with zhonghuacerite/olekminskite/ancylite assemblages occur throughout the otherwise REE-poor calciocarbonatites (~0.2% Total Rare Earth Oxides in bulk rock). Late hydrothermal events strongly influenced the modern-day mineral assemblages with much of the existing ore mineral textures interpreted as hydrothermal reworkings of pre-existing REE-bearing minerals. A comparison of the fresh carbonatite and the paleoregolith geochemistry suggests minimal horizontal migration of ore elements during paleoregolith formation, with the overlying paleoregolith material broadly reflecting the underlying carbonatite trace and minor element signatures. This allows the inference of an approximately 5× upgrade in REE (and Nb) concentrations from the primary carbonatite to the overlying paleoregolith. Mt Weld shows distinct geological, mineralogical and isotopic differences to other currently mined carbonatite-associated REE deposits, such as Bayan Obo (China), Mountain Pass (USA) and the Mianning-Dechang belt (China), which suggests that fundamentally different carbonatite mantle sources and evolutionary paths can form world-class REE ore bodies.
Fluid-Induced Metamorphism and Deformation at the Eastern Boundary of the Sveconorwegian Province
Authors: Urueña C L , Möller C 
Published: February 2024

Abstract
The Sveconorwegian orogen in Scandinavia and the Grenville orogen in Canada are both remnants of large and hot orogens that formed part of the supercontinent Rodinia around 1 billion years ago. Formerly deeply buried portions of crust in these orogens are exposed and offer insights into the tectonic dynamics of the basement within large orogens. The Eastern Segment of the Sveconorwegian Province hosts a ~ 30 000 km2 crustal portion that was buried to c. 40 km depth at a late stage of the orogeny, 980–960 Ma ago, and is bound towards the foreland in the east by a ~ 25 km wide zone of step anastomosing deformation, the Frontal wedge. This zone represents the outermost ductile deformation that developed within the crystalline basement in the orogen. We investigated a heterogeneously deformed and recrystallised syenodiorite with the aim to understand the character of the deformation-related metamorphism within the Frontal wedge. Field relations, microtextures, and mineral reactions show that the metamorphic recrystallisation was governed by hydrous fluid infiltration along the ductile deformation zones. Equilibrium was attained on a millimetre scale only and metamorphic recrystallisation was dependent on the introduction of hydrous fluid. The metamorphism reached high-pressure epidote-amphibolite-facies; geothermobarometric estimates suggest 540°C to 600°C and 9 to 12 kbar. Metamorphic zircon formed during the breakdown of Zr-bearing igneous phases, primarily baddeleyite. SIMS U–Pb analyses of igneous zircon and baddeleyite date the igneous crystallisation of the syenodiorite at 1230 ± 6 Ma. Metamorphic zircon grains are &lt;20 μm and too small for precise dating, but yielded ages around 1 Ga. Collectively, the metamorphic data indicate that subvertical movements along steep planes within the Frontal wedge allowed for the regional-scale tectonic burial to ~40 km depth of the Eastern Segment to the west. Some of the same steep deformation structures were re-utilised as discrete movement planes during later exhumation.
Comment on ‘The Generation of Eocene Mafic Dike Swarms During the Exhumation of a Core Complex, Biarjmand Area, NE Iran’ by Azizi et al. (2023), Journal of Petrology, 64, 1–18
Authors: Malekpour-Alamdari Ahmadreza 
Published: February 2024

Abstract
Azizi, H., Daneshvar, N., Asahara, Y., Minami, M. & Anma, R. (2023). The generation of Eocene mafic dike swarms during the exhumation of a Core complex, Biarjmand area, NE Iran. Journal of Petrology64, 1–18 have attributed the E–W-oriented mafic dike swarm in the Biarjmand metamorphic core complex to an Eocene extensional event which is much younger than a previously suggested Late Jurassic–Early Cretaceous age. They proposed that the emplacement of these dikes occurred in a rapid extensional regime coeval with the exhumation of the core complex after gravitational instability in the Central Iran/Eurasia collision zone. I appreciate the opportunity this article provides to shed light on specific aspects of the Late Mesozoic–Early Cenozoic continental extension within the Eurasian sector of the Neotethys subduction system. However, I here bring to attention certain discrepancies within Azizi et al.'s publication. Specifically, the assignment of an Eocene age to the emplacement of the E–W-oriented dike swarm, even though purportedly supported by U–Pb zircon dating, appears to be at odds with field observations and previously published geochronological data. Furthermore, the article contains internal contradictions in its presentation of the core complex model for the study area. It is important to note that Malekpour-Alamdari, A., Axen, G. J., Heizler, M. T. & Hassanzadeh, J. (2017). Large-magnitude continental extension in the northeastern Iranian plateau: insight from K-feldspar 40Ar/39Ar thermochronology from the Shotor Kuh-Biarjmand metamorphic core complex. Geosphere13, 1207–1233 previously documented the geochronological-based metamorphic core complex model of the area. Regrettably, despite its direct relevance, these earlier works have not been acknowledged in Azizi et al.'s paper. In this comment, I outline the problems with the structural and regional geology, the zircon U–Pb age of the dike samples, the age of the dike swarm, and the geodynamic interpretations in Azizi et al.'s work.
Price for waiting: the adverse outcomes of boarding critically ill elderly medical patients in the emergency department
Authors: Huang Kuang-Wen , Yin Chun-Hao , Chang Renin , Chen Jin-Shuen , Chen Yao-Shen 
Published: February 2024

Abstract

Purpose
Boarding, the period in which a patient spends in the emergency department (ED) before admission, may be hazardous to critically ill patients, particularly the elderly. This study investigated the associations of boarding with hospital course, prognosis, and medical expenditure in older patients.

Methods
From January 2019 to December 2021, the medical records of older patients (age ≥ 65) visiting the ED of a tertiary referral hospital who were admitted to the medical intensive care unit (ICU) were retrospectively reviewed. Eligible patients were categorized into two groups according to boarding time with a cutoff set at 6 h. Primary outcomes were in-hospital mortality, ICU/hospital length of stay, and total/average hospitalization cost. Subgroup analyses considered age and disease type.

Results
Among 1318 ICU admissions from the ED, 36% were subjected to boarding for over 6 h. Prolonged boarding had a longer ICU (8.9 ± 8.8 vs. 11.2 ± 12.2 days, P &lt; .001) and hospital (17.8 ± 20.1 vs. 22.8 ± 23.0 days, P &lt; .001) stay, higher treatment cost (10.4 ± 13.9 vs. 13.2 ± 16.5 thousands of USD, P = .001), and hospital mortality (19% vs. 25% P = .020). Multivariate regression analysis showed a longer ICU stay in patients aged 65–79 (8.3 ± 8.4 vs. 11.8 ± 14.2 days, P &lt; .001) and cardiology patients (6.9 ± 8.4 vs. 8.8 ± 9.7 days, P = .001). Besides, the treatment cost was also higher for both groups (10.4 ± 14.6 vs. 13.7 ± 17.7 thousands of USD, P = .004 and 8.4 ± 14.0 vs. 11.7 ± 16.6 thousands of USD, P &lt; .001, respectively).

Conclusion
Extended ED boarding for critically ill medical patients over 65 years old was associated with negative outcomes, including longer ICU/hospital stays, higher treatment costs, and hospital mortality.
A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice
Authors: Leu Chia-Luen , Lam Daniel D , Salminen Aaro V , Wefers Benedikt , Becker Lore , Garrett Lillian , Rozman Jan , Wurst Wolfgang , Hrabě de Angelis Martin , Hölter Sabine M , Winkelmann Juliane , Williams Rhîannan H 
Published: February 2024

Abstract
Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable or unpleasant sensations in the legs during rest periods. To relieve these sensations, patients move their legs, causing sleep disruption. While the pathogenesis of RLS has yet to be resolved, there is a strong genetic association with the MEIS1 gene. A missense variant in MEIS1 is enriched sevenfold in people with RLS compared to non-affected individuals. We generated a mouse line carrying this mutation (p.Arg272His/c.815G&gt;A), referred to herein as Meis1R272H/R272H (Meis1 point mutation), to determine whether it would phenotypically resemble RLS. As women are more prone to RLS, driven partly by an increased risk of developing RLS during pregnancy, we focused on female homozygous mice. We evaluated RLS-related outcomes, particularly sensorimotor behavior and sleep, in young and aged mice. Compared to noncarrier littermates, homozygous mice displayed very few differences. Significant hyperactivity occurred before the lights-on (rest) period in aged female mice, reflecting the age-dependent incidence of RLS. Sensory experiments involving tactile feedback (rotarod, wheel running, and hotplate) were only marginally different. Overall, RLS-like phenomena were not recapitulated except for the increased wake activity prior to rest. This is likely due to the focus on young mice. Nevertheless, the Meis1R272H mouse line is a potentially useful RLS model, carrying a clinically relevant variant and showing an age-dependent phenotype.
Plant-based fat supply is associated with reduced ADHD disease burden
Authors: Ni Duan , Senior Alistair , Raubenheimer David , Simpson Stephen J. , Nanan Ralph 
Published: February 2024

AbstractObjectivesAttention-Deficit/Hyperactivity Disorder (ADHD) is emerging as a major neurodevelopmental disorder on a global scale, affecting both children and increasingly adult population. Its aetiology is unclear but seems to involve genetic and environmental factors, particularly diets and nutrients. However, most studies so far only focused on specific nutrients or dietary patterns, lacking systematic perspectives of their potential interactions, and also neglecting other confounding factors like socioeconomic status. Thus, we aim to systematically interrogate the association between nutrient supply, reflecting the food exposure and environment, socioeconomic status and ADHD disease burden at a global level over time.MethodsADHD disease burden, macronutrient supply and gross domestic product (GDP) were collated from more than 150 countries from 1990 to 2018 and analyzed with nutritional geometry generalized additive mixed models (GAMMs).ResultsModelling results suggested the interactive effects of nutrients and socioeconomic status on ADHD. Fat, especially plant-based fat supply, is associated with decreased ADHD disease burden. These associations were conserved across sexes and ages and were not confounded by the total energy supply.ConclusionsGlobally, far, particularly plant-based fat supply seemed to drive the reduction of ADHD disease burden, which is supported by previous reports about the amelioration of ADHD by ketogenic diets. Further in-depth studies are needed to elucidate the underlying mechanistic and may inform future targeted dietary interventions for ADHD prevention and/or treatment.
RAMDS: Retrieval Augmented Medical Diagnosis System for Explainable Breast Cancer Classification from Ultrasound Images
Authors: Johnson Ethan Thomas , Bande Jathin K , Thomas Johnson 
Published: February 2024

AbstractBreast cancer, a leading cause of cancer-related deaths in women, presents a growing challenge in medical diagnostics. Despite the effectiveness of mammography and ultrasound, the ambiguity in non-invasive scans often necessitates invasive procedures. Our primary goal was to create an AI model that could predict breast cancer with high negative predictive value and reduce unnecessary procedures. This study introduces the Retrieval-Augmented Medical Diagnosis System (RAMDS) for breast cancer, a novel approach combining an AI model with a retrieval-augmented mechanism to enhance diagnostic accuracy and explainability. The RAMDS employs a pretrained ResNet 34 model, fine-tuned on breast ultrasound image datasets from four countries. It integrates a similarity-based weighted adjustment mechanism to compare new cases with historical diagnoses. It’s like having an experienced doctor who remembers every case they’ve ever seen and uses that knowledge to make better decisions. RAMDS improved sensitivity by 11%, and negative predictive value by 9% when compared to the base model. Notably, the RAMDS improves explainability by linking AI predictions to similar historical cases, aligning with the medical community’s interest in transparent and understandable AI decisions.A unique feature of this system is its adaptability to varied imaging contexts without retraining, addressing the challenge of dataset variability across medical institutions. In conclusion, the RAMDS offers a significant advancement in breast cancer diagnosis, combining enhanced accuracy, explainability, and adaptability. It holds promise for clinical application, though further research is needed to optimize its performance and integrate multi-modal data.
Multistability and predominant double-positive states in a four node mutually repressive network: a case study of Th1/Th2/Th17/T-reg differentiation
Authors: Duddu Atchuta Srinivas , Andreas Elizabeth , Harshavardhan BV , Grover Kaushal , Singh Vivek Raj , Hari Kishore , Jhunjhunwala Siddharth , Cummins Breschine , Gedeon Tomas , Jolly Mohit Kumar 
Published: February 2024

AbstractElucidating the emergent dynamics of complex regulatory networks enabling cellular differentiation is crucial to understand embryonic development and suggest strategies for synthetic circuit design. A well-studied network motif often driving cellular decisions is a toggle switch - a set of two mutually inhibitory lineage-specific transcription factors A and B. A toggle switch often enables two possible mutually exclusive states - (high A, low B) and (low A, high B) - from a common progenitor cell. However, the dynamics of networks enabling differentiation of more than two cell types from a progenitor cell is not well-studied. Here, we investigate the dynamics of four master regulators A, B, C and D inhibiting each other, thus forming a toggle tetrahedron. Our simulations show that a toggle tetrahedron predominantly allows for co-existence of six ‘double positive’ or hybrid states where two of the nodes are expressed relatively high as compared to the remaining two - (high A, high B, low C, low D), (high A, low B, high C, low D), (high A, low B, low C, high D), (low A, high B, high C, low D), (low A, low B, high C, high D) and (low A, high B, low C, high D). Stochastic simulations showed state-switching among these phenotypes, indicating phenotypic plasticity. Finally, we apply our results to understand the differentiation of naive CD4+T cells into Th1, Th2, Th17 and Treg subsets, suggesting Th1/Th2/Th17/Treg decision-making to be a two-step process. Our results reveal multistable dynamics and establish the stable co-existence of hybrid cell-states, offering a potential explanation for simultaneous differentiation of multipotent naïve CD4+ T cells.
Renal-Derived Human sPRR Does Not Increase Blood Pressure in High Fat Diet Mice
Authors: Arthur Gertrude , Biel Katherine , Osborn Jeffrey L , Hinds Terry D. , Gong Ming , Loria Analia S. 
Published: February 2024

ABSTRACTObesity is a risk factor for hypertension. Obesity-related hypertension has been associated with elevated plasma soluble prorenin receptor (sPRR) particularly in men. Additionally, renal PRR and sPRR protein expression is upregulated during obesity and diabetes. However, whether renal-derived human sPRR (HsPRR) may influence the intrarenal RAS status to regulate blood pressure and kidney function during obesity has not been investigated. Therefore, we studied the role of collecting duct (CD) derived-HsPRR on blood pressure and kidney function in male and female mice during obesity. Eight-week-old male and female CD-HsPRR mice were placed on a high fat diet for 25 weeks. HsPRR increased renal sPRR concentration but did not change its circulating levels in male and female littermates compared to CTL mice. GFR, water intake and urine flow were not influenced by the CD-HsPRR expression in either sex. Moreover, after 21 weeks of HFD, blood pressure was similar between groups, while only male CD-HsPRR mice showed an impaired pressor response to losartan. In the renal cortex, male CD-HsPRR mice showed increased renin and AT1R mRNA expression associated with increased AQP2, and ENaC subunits protein expression. These data indicate that renal-derived HsPRR induces local upregulation in renin, AT1R and sodium/water transporters in male mice without altering renal hemodynamics or blood pressure. In obese females, CD-HsPRR expression did not affect blood pressure or renal function, which suggests that females may be protected from obesity induced renal function impairment and hypertension.
Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
Authors: Shi Hongxue , Wang Xiaobo , Gerlach Brennan , Yurdagul Arif , Moore Mary P. , Mirshahi Faridoddin , Ronzoni Luisa , Sanyal Arun J. , Valenti Luca , Lin Chyuan-Sheng , Tabas Ira 
Published: February 2024

AbstractBackground and aimsHepatocyte apoptosis is a key feature of non-alcoholic steatohepatitis (NASH), but the fate of apoptotic hepatocytes in NASH is poorly understood. Herein we explore the hypothesis that impaired TIM4-mediated clearance of dead hepatocytes by liver macrophages (efferocytosis) is impaired in NASH and drives the progression to liver fibrosis.MethodsKupffer cell (KC)-TIM4 expression and efferocytosis were assayed in normal and NASH liver from humans and diet-induced NASH mice. The engulfment of human and mouse apoptotic hepatocytes by primary human and mouse liver KCs was assayedex vivo. Causation was assessed in NASH mice using anti-TIM4 antibodies, KC-TIM4-knockout, or inducible KC-TIM4 expression, with analyses focused on efferocytosis of apoptotic hepatocytes by liver macrophages and liver fibrosis.ResultsIn human and mouse NASH liver, apoptotic hepatocytes accumulated and was associated with the loss of the KC efferocytosis receptor TIM4. Anti-TIM4 inhibited the engulfment of apoptotic hepatocytes by primary human and mouse liver KCsex vivo, and anti-TIM4 administration to early NASH mice worsened liver macrophage efferocytosis and accelerated the progression to fibrotic NASH. A similar result was obtained by genetically deleting TIM4 in KCs in NASH mice. Most importantly, genetic restoration of macrophage TIM4 in NASH mice enhanced the clearance of apoptotic hepatocytes by liver macrophages and decreased liver fibrosis.ConclusionsThe loss of macrophage TIM4 that occurs during NASH progression impairs the clearance of apoptotic hepatocytes by liver macrophages, which subsequently promotes the progression to fibrotic NASH. This pathogenic sequence of events can be prevented by restoring macrophage TIM4, suggesting that future therapeutic approaches designed to boost TIM4 expression in liver macrophages could represent a novel strategy to prevent fibrotic NASH progression.Lay summaryNonalcoholic steatohepatitis (NASH) is emerging as the leading cause of liver disease, but the processes leading to liver fibrosis in NASH, which determines clinical outcome, are incompletely understood. Our study provides evidence impaired clearance of dead liver cells by liver macrophages in NASH, which is due to loss of a macrophage receptor called TIM4, contributes to liver fibrosis. Knowledge of this process may suggest new ways to bolster the clearance of dead liver cells in NASH and thereby prevent the progression to liver fibrosis and subsequent liver disease.