bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study of the sensitivity of ultra-high-resolution CT and high-resolution CT in the diagnosis of isolated fenestral otosclerosis
Authors: Xu Ning , Ding Heyu , Tang Ruowei , Li Xiaoshuai , Zhang Zhengyu , Lv Han , Dai Chihang , Qiu Xiaoyu , Huang Yan , Han Xu , Wang Guo-Peng , Liu Yuhe , Gong Shusheng , Yang Zhenghan , Wang Zhenchang , Zhao Pengfei 
Published: November 2023

Abstract
Purpose
To compare the diagnostic sensitivity of ultra-high-resolution computed tomography (U-HRCT) and HRCT in isolated fenestral otosclerosis (IFO).

Methods
A retrospective analysis was conducted on 85 patients (85 ears) diagnosed with IFO between October 2020 and November 2022. U-HRCT (0.1 mm thickness) was performed for 20 ears, HRCT (0.67 mm thickness) for 45 ears, and both for 20 ears. The images were evaluated by general radiologists and neuroradiologists who were blinded to the diagnosis and surgical information. The diagnostic sensitivity of U-HRCT and HRCT for detecting IFO was compared between the two groups.

Results
Excellent inter-observer agreement existed between the two neuroradiologists (Cohen’s κ coefficient 0.806, 95% CI 0.692–0.920), with good agreement between the general radiologists (Cohen’s κ coefficient 0.680, 95% CI 0.417–0.943). U-HRCT had a sensitivity of 100% (40/40 ears) for neuroradiologists and 87.5% (35/40 ears) for general radiologists, significantly higher than HRCT (89.2% [58/65 ears] for neuroradiologists; 41.5% [27/65 ears] for general radiologists) (p = 0.042, p′ < 0.000). General radiologists’ sensitivity with HRCT was significantly lower compared to neuroradiologists (p < 0.000), but no significant difference was observed when general radiologists switched to U-HRCT (p = 0.152). Among the 20 ears that underwent both examinations, U-HRCT detected lesions smaller than 1 mm in 5 ears, whereas HRCT’s sensitivity for neuroradiologists was 40% (2/5 ears), significantly lower than for lesions larger than 1 mm (93.3%, 14/15 ears, p = 0.032).

Conclusion
U-HRCT exhibits higher sensitivity than HRCT in diagnosing IFO, suggesting its potential as a screening tool for suspected otosclerosis patients.

Critical relevance statement
Ultra-high-resolution computed tomography has the potential to become a screening tool in patients with suspected otosclerosis and to bridge the diagnostic accuracy gap between general radiologists and neuroradiologists.

Key points
• U-HRCT exhibits higher sensitivity than HRCT in the diagnosis of IFO.
• U-HRCT has a significant advantage in the detection of less than 1 mm IFO.
• U-HRCT has the potential to be used for screening of patients with suspected otosclerosis.

Graphical Abstract
Evaluation of preventive tract embolization with standardized gelatin sponge slurry on chest tube placement rate after CT-guided lung biopsy: a propensity score analysis
Authors: Grange Rémi , Di Bisceglie Mathieu , Habert Paul , Resseguier Noémie , Sarkissian Robin , Ferre Marjorie , Dassa Michael , Grange Sylvain , Izaaryene Jean , Piana Gilles 
Published: November 2023

Abstract
Background
To evaluate the effect of tract embolization (TE) with gelatin sponge slurries during a percutaneous lung biopsy on chest tube placement and to evaluate the predictive factors of chest tube placement.

Methods
Percutaneous CT-guided lung biopsies performed with (TE) or without (non-TE) tract embolization or between June 2012 and December 2021 at three referral tertiary centers were retrospectively analyzed. The exclusion criteria were mediastinal biopsies, pleural tumors, and tumors adjacent to the pleura without pleural crossing. Variables related to patients, tumors, and procedures were collected. Univariable and multivariable analyses were performed to determine risk factors for chest tube placement. Furthermore, the propensity score matching analysis was adopted to yield a matched cohort.

Results
A total of 1157 procedures in 1157 patients were analyzed, among which 560 (48.4%) were with TE (mean age 66.5 ± 9.2, 584 men). The rates of pneumothorax (44.9% vs. 26.1%, respectively; p < 0.001) and chest tube placement (4.8% vs. 2.3%, respectively; p < 0.001) were significantly higher in the non-TE group than in the TE group. No non-targeted embolization or systemic air embolism occurred. In the whole population, two protective factors for chest tube placement were found in univariate analysis: TE (OR 0.465 [0.239–0.904], p < 0.05) and prone position (OR 0.212 [0.094–0.482], p < 0.001). These data were confirmed in multivariate analysis (p < 0.001 and p < 0.0001 respectively). In the propensity matched cohort, TE reduces significatively the risk of chest tube insertion (OR = 0.44 [0.21–0.87], p < 0.05).

Conclusions
The TE technique using standardized gelatin sponge slurry reduces the need for chest tube placement after percutaneous CT-guided lung biopsy.

Critical relevance statement
The tract embolization technique using standardized gelatin sponge slurry reduces the need for chest tube placement after percutaneous CT-guided lung biopsy.

Key points
1. Use of tract embolization with gelatine sponge slurry during percutaneous lung biopsy is safe.
2. Use of tract embolization significantly reduces the risk of chest tube insertion.
3. This is the first multicenter study to show the protective effect of tract embolization on chest tube insertion.

Graphical Abstract
Male refractory hypospadias with sexual reversal: a case report
Authors: Zhao Jianfeng , Chen Gang , Chen Jun , Qian Le 
Published: November 2023

Abstract
Background
Hypospadias is one of the most prevalent urogenital malformations in clinic. However, some hypospadias may have a more complex disorder of sex development. Usually, hypospadias in these patients is severe. Among them, the 46,XX male sex reversal syndrome is a rare disorder of sex development, and this may be the main reason for this type of hypospadias being difficult to repair.

Case presentation
We present a Han nationality 19-year-old male with failure of repeated repair of hypospadias. No sperm was found on semen analysis. Lingual mucosal graft was carried out for this patient. It still did not succeed after using lingual mucosal graft repair. Karyotype analysis of this patient confirmed 46,XX karyotype.

Conclusion
Hypospadias with 46,XX male sex reversal syndrome is hard to repair. Chromosome karyotype examination in patients with hypospadias is suggested. Genetic testing is recommended. In the future, further research is needed on the pathogenesis of disease and how to treat and prevent it.
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
Authors: Bayati Paria , Taherian Marjan , Soleimani Mansoureh , Farajifard Hamid , Mojtabavi Nazanin 
Published: November 2023

Abstract
Background
The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed to assess the potential of the induced pluripotent stem cells (IPS) in modulating the expression of the cardinal genes of the Wnt pathway in a mouse model of idiopathic pulmonary fibrosis (IPF).

Methods
C57Bl/6 mice were randomly divided into three groups of Control, Bleomycin (BLM), and BLM + IPS; the BLM mice received intratracheal instillation of bleomycin, BLM + IPS mice received tail vein injection of IPS cells 48 h post instillation of the BLM; The Control group received Phosphate-buffered saline instead. After 3 weeks, the mice were sacrificed and Histologic assessments including hydroxy proline assay, Hematoxylin and Eosin, and Masson-trichrome staining were performed. The expression of the genes for Wnt, β-Catenin, Lef, Dkk1, and Bmp4 was assessed utilizing specific primers and SYBR green master mix.

Results
Histologic assessments revealed that the fibrotic lesions and inflammation were significantly alleviated in the BLM + IPS group. Besides, the gene expression analyses demonstrated the upregulation of Wnt, β-Catenin, and LEF along with the significant downregulation of the Bmp4 and DKK1 in response to bleomycin treatment; subsequently, it was found that the treatment of the IPF mice with IPS cells results in the downregulation of the Wnt, β-Catenin, and Lef, as well as upregulation of the Dkk1, but not the Bmp4 gene (P values < 0.05).

Conclusion
The current study highlights the therapeutic potential of the IPS cells on the IPF mouse model in terms of regulating the aberrant expression of the factors contributing to the Wnt signaling pathway.
Efficient and privacy-preserving multi-agent systems for smart city carpooling with k-regret queries and differential privacy
Authors: Chen Fei , Zhang Xinjian , Ning Bo , Yang Chao , Jia Xiao 
Published: November 2023

AbstractMulti-Agent Systems are characterized by the presence of multiple independent agents and find diverse applications. In the context of smart cities, MAS is employed in traffic management to enhance operational efficiency, optimize resource utilization, and improve the quality of life for residents. This research paper focuses on the design of a multi-agent intelligent scheduling system, where passengers, vehicles, and carpooling platforms serve as intelligent agents. The primary objective of passengers is to identify suitable shared vehicles based on criteria such as waiting time, budget constraints, and willingness to carpool. Vehicles, on the other hand, organize their schedules based on passenger demands and designated routes. The carpooling platform takes into account resource allocation priority and optimization problems to ensure the efficient operation of the system. To address the issue of vehicle ordering,k-regret queries are utilized, while passenger preferences provide insight into determining loss factors. To safeguard privacy, differential privacy techniques and a random response mechanism are employed when dealing with multiple passenger queries. Furthermore, a direction-preserving insertion verification method is implemented to mitigate computational complexity. The effectiveness and efficiency of the proposed approach are validated through experimentation.
A global bibliometric and visualized analysis of the status and trends of gastroparesis research
Authors: Li Meng , Gao Ning , Wang Shaoli , Guo Yufeng , Liu Zhen 
Published: November 2023

Abstract
Background
Gastroparesis has a substantial impact on the quality of life but has limited treatment options, which makes it a public health concern. No bibliometric studies on gastroparesis have been published thus far. Thus, this article aims to summarize and analyze research hotspots to provide a reference for clinical researchers.

Materials and methods
Gastroparesis-related research articles were searched in the Web of Science Core Collection (WOSCC), and relevant information was extracted after screening. A total of 1033 documents were analyzed with the bibliometric method using Microsoft Excel, Citespace, and VOSviewer.

Results
Overall, our search retrieved 1033 papers contributed by 966 research institutions from 53 countries. Since 1980, publications in this field have increased rapidly. United States (n = 645) and Temple University (n = 122) were the most productive country and institution, respectively. Parkman, with 96 publications, was the most prominent author.

Conclusions
Research hotspots in gastroparesis can be summarized into four domains: innovation in diagnostic modalities, change of oral therapeutic agents, choice of surgical interventions, and pathological mechanisms. Future research on gastroparesis should focus on the quality of life of patients, diagnostic techniques, pyloromyotomy, and transpyloric stent placement.
Women empowerment and food-nutrition security in Sierra Leone: The Gender Model Family approach
Authors: Ayamga Joseph Awimboora , Ayawine Alice , Ayentimi Desmond Tutu 
Published: November 2023

Abstract
Background
This research is conducted in the context of an integrated food security and nutrition project implemented by the Social Enterprise Development Foundation (SEND Sierra Leone) and Agro Forestry Farmers Association (AFFA) in rural Kenema and Pujehun Districts. This paper presents a qualitative ‘baseline’ action-learning research on the impact of the Gender Model Family (GMF) approach on women empowerment and the effects on enhanced outcomes along the agriculture-nutrition pathway. Qualitative data were collected using in-depth face-to-face interviews and focused group discussion (FGD) from the GMF beneficiaries.

Results
Linking Agriculture, Natural Resource Management and Nutrition (LANN) has nutrition security as its aim, and the project objectives and indicators focus on nutrition, not gender—however, this ‘baseline’ action-learning research recognized that gender is a major underlying factor. The evidence suggests that the GMF approach fosters women empowerment and enhances outcomes in food and nutrition security as there has been a change in social rules about men taking part in domestic household work and women involvement in family decision-making.

Conclusions
Given that women play crucial roles as administrators of household food and nutrition security, empowering them is intimately related to the consolidation of household food systems, improves nutrition intake and the fight against food-nutrition insecurity in rural Africa.
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Authors: Liu Zhaoyun , Xu Xintong , Liu Hui , Zhao Xianghong , Yang Chun , Fu Rong 
Published: November 2023

AbstractMultiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit MM patients. Immune checkpoints can negatively modulate the immune system and are closely associated with immune escape. Immune checkpoint-related therapy has attracted much attention and research in MM. However, the efficacy of those therapies need further improvements. There need more thoughts about the immune checkpoint to translate their use in clinical work. In our review, we aggregated the currently known immune checkpoints and their corresponding ligands, further more we propose various ways of potential translation applying treatment based on immune checkpoints for MM patients.
Accelerating Pneumococcal Conjugate Vaccine introductions in Indonesia: key learnings from 2017 to 2022
Authors: Athiyaman Anithasree , Herliana Putri , Anartati Atiek , Widyastuti Niken , Yosephine Prima , Tandy Gertrudis , Karolina Sherli 
Published: November 2023

AbstractDespite high pneumococcal disease and economic burden in Indonesia and interest to introduce pneumococcal conjugate vaccine (PCV), there were challenges in establishing a comprehensive strategy to accelerate and enable the introduction in country in the early 2010s. Starting in 2017, Clinton Health Access Initiative and partners supported the government of Indonesia with evidence-based decision-making and implementation support for introducing PCV into the routine immunization program. Indonesia has since accelerated PCV roll out, with nationwide reach achieved in 2022. On the path to PCV introduction, several challenges were observed that impacted decision making on whether and on how to optimally roll out PCV, resulting in significant introduction delays; including (1) a complex country context with a devolved government structure, fragmented domestic funding streams, and an imminent transition out of major immunization donor (Gavi) support; (2) strong preference to use domestically sourced products, with limited experience accessing global pooled procurement mechanism including for vaccines; and (3) concerns around programmatic feasibility and sustainability. This case study documents key insights into the challenges experienced and how those were systematically addressed to accelerate new vaccine introduction in Indonesia, with support from local and global stakeholders over time. The learnings would be beneficial for other countries yet to introduce critical new vaccines, in particular those with similar archetype as Indonesia e.g., middle-income countries with domestic manufacturing capacity and/or countries recently transitioning out of Gavi support.
Risk of avoidant/restrictive food intake disorder in patients with inflammatory bowel disease: predictive value of disease phenotype, disease activity and food literacy
Authors: Yin Tingting , Tu Wenjing , Li Yiting , Yang Min , Huang Lina , Zhang Sumin , Xu Guihua 
Published: November 2023

Abstract
Background
Avoidant/Restrictive Food Intake Disorder (ARFID) is a newly described eating disorder. Adequate levels of food literacy allow individuals to have adequate food choices. This study aimed to assess the prevalence of ARFID and the level of food literacy in patients with inflammatory bowel disease (IBD) and to analyse the correlation between ARFID and food literacy.

Method
This cross-sectional study screened for ARFID and assessed food literacy levels in patients with IBD attending four tertiary hospitals in China. ARFID risk was measured using the Nine Item Avoidant/Restrictive Food Intake Disorder Screen (NIAS). Food literacy was assessed using the Food Literacy Evaluation Questionnaire (Chinese version, FLEQ-Ch).The relationship between individual NIAS scores and food literacy variables was analysed to assess which food literacy aspect is positively or negatively associated with NIAS scores. Stepwise linear regression analysis was performed to identify the possible predictors of NIAS scores in patients with IBD.

Result
A total of 372 IBD subjects completed the NIAS and FLEQ-Ch. The overall mean NIAS scores for the IBD cohort was 28.16 ± 8.03 (p < 0.01), and of the 372 participants, 123 (32.5%) had positive ARFID risk scores (≥ 10 NIAS-picky eating, ≥ 9 NIAS-poor appetite, and ≥ 10 NIAS-fear of negative consequences).The NIAS scores were inversely associated with food literacy levels (β =  − 0.299; p < 0.01).Disease phenotype, disease activity, and food literacy in patients with IBD provided valuable predictive insights for avoiding positive outcomes in ARFID.

Conclusion
This study shows that the risk of ARFID in the cohort of patients with IBD is associated with their inadequate food literacy levels. Therefore, this study supports the notion that patients with IBD should be assessed for food literacy regardless of whether they are currently diagnosed with ARFID. Specifically, for early identification of those at risk for ARFID in IBD, disease phenotype, disease activity, and food literacy should be routinely considered in clinical practice.The food literacy awareness of patients must be investigated and improved to predict the risk occurrence of ARFID and encourage healthy eating behaviour.
Installation of the developing nephron in the fetal human kidney during advanced pregnancy
Authors: Minuth Will W. 
Published: November 2023

Abstract
Background
The kidneys of preterm and low birth weight babies reflect vulnerability, since several noxae can evoke the termination of nephron formation. This again leads to oligonephropathy with severe consequences for health in the later life. While the clinical parameters have been intensely investigated, only little is known about the initial traces left by the noxae. For the fetal human kidney, solely the lack of basophilic S-shaped bodies and the reduction in width of the nephrogenic zone were registered. It is not known in how far also the involved progenitor cells, the earlier nephron stages, the collecting duct (CD) ampullae, and the local interstitium are collaterally harmed.

Aim
The interstitium at the forming nephron is heterogeneously structured. Thereby, it fulfills quite different mastering and integrative tasks. Since data dealing with the installation of a nephron is not available, the microanatomical features were recorded.

Results
The microscopic specimens show that the installation of the transient stages of nephron anlage is not synchronized. Instead, it is controlled within a nephrogenic compartment of the nephrogenic zone. It starts near the renal capsule by positioning the nephrogenic niche so that the nephrogenic progenitor cells face the epithelial progenitor cell at the tip of a CD ampulla. Then, the induced nephrogenic progenitor cells assimilate in the pretubular aggregate. While its medial part remains opposite the head of the CD ampulla, at its proximal end, the primitive renal vesicle is formed. Only a part of it separates to stick to the section border between the head and conus of the CD ampulla. This marks the link with the future connecting tubule at the distal pole of the extending renal vesicle. Meanwhile, the proximal pole is mounted next to the connecting tubule of an earlier developed nephron. The resulting two-point mounting serves a common elongation of the conus at the CD ampulla and the medial aspect of the comma-shaped body. In the S-shaped body, it supports to defoliate the arising glomerulus and to link it with the perforating radiate artery at its deep lateral aspect.

Conclusions
The investigation depicts that the installation is an interactive process between the stages of nephron anlage and its structural neighbors. A special meaning has the interjacent interstitium. It is vital for the positioning, shaping, and physiological integration. Due to its special location, this is mainly exposed to noxae.
Modelling the associations between academic engagement, study process and grit on academic achievement of physical education and sport university students
Authors: Tannoubi Amayra , Quansah Frank , Magouri Iteb , Chalghaf Nasr , Bonsaksen Tore , Srem-Sai Medina , Hagan John Elvis , Handrianto Ciptro , Azaiez Fairouz , Bragazzi Nicola Luigi 
Published: November 2023

Abstract
Objective
The present study examined the impact of academic engagement, study processes, and grit on the academic achievement of physical education and sport university students.

Methods
An internet-based survey recruited 459 university students aged 19–25 years (M = 21 ± 1.3) in physical education and sports (PES) to fill out questionnaires on Physical Education-Study Process Questionnaire (PE-SPQ), Physical Education-Grit (PE-Grit), academic engagement (A-USEI), and Grade Point Average (GPA). A path analysis was carried out to understand variable relationships.

Results
Data from each variable exhibited symmetrical and normal distribution, as indicated by the skewness and kurtosis values. The model’s fit indices showed sufficient Comparative Fit Index (CFI = 0.92), Tucker-Lewis Index (TLI = 0.90), Goodness of Fit Index (GFI = 0.99) and Normed Fit Index (NFI = 0.90) and showed acceptable levels. The results indicated a statistically significant positive impact of engagement (β = 0.299, p < 0.001) and study processes (β = 0.397, p < 0.001) on academic achievement. However, the effect of grit on achievement was non-significant.

Conclusions
Academic engagement as well as study processes are two important factors predicting academic achievement while grit seems to be not a major predictor. Hence, physical education and sport faculty and university administrators should prioritize student engagement as a determinant of academic outcomes by reforming or redesigning physical education and sport curriculum modules that can facilitate engagement.