bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials
Authors: Le Pennec Jean , Picart Catherine , Vivès Romain R. , Migliorini Elisa 
Published: November 2023

AbstractGlycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has emerged as a widely adopted strategy in medical applications, owing to their biocompatibility and ability to control the release of bioactive molecules. Nevertheless, immobilized GAGs on biomaterials can elicit distinct cellular responses compared to their soluble forms, underscoring the need to understand the interactions between GAG and bioactive molecules within engineered functional biomaterials. By controlling critical parameters such as GAG type, density, and sulfation, it becomes possible to precisely delineate GAG functions within a biomaterial context and to better mimic specific tissue properties, enabling tailored design of GAG‐based biomaterials for specific medical applications. However, this requires access to pure and well‐characterized GAG compounds, which remains challenging. This review focuses on different strategies for producing well‐defined GAGs and explores high‐throughput approaches employed to investigate GAG–growth factor interactions and to quantify cellular responses on GAG‐based biomaterials. These automated methods hold considerable promise for improving the understanding of the diverse functions of GAGs. In perspective, the scientific community is encouraged to adopt a rational approach in designing GAG‐based biomaterials, taking into account the in vivo properties of the targeted tissue for medical applications.
Soft Kirigami Composites for Form‐Finding of Fully Flexible Deployables
Authors: Zavodnik Jan , Wang Yunbo , Yan Wenzhong , Brojan Miha , Jawed Mohammad Khalid 
Published: November 2023

AbstractA new class of thin flexible structures is introduced that morph from flat into prescribed 3D shapes through strain mismatch between layers of a composite plate. To achieve control over the target shape, two different concepts are coupled. First, motivated by biological growth, strain mismatch is applied between the flat composite layers to transform it into a 3D shape. Depending on the amount of the applied strain mismatch, the transformation involves buckling into one of the available finite number of deformation modes. Second, inspired by kirigami, portions of the material are removed from one of the layers according to a specific pattern. This dramatically increases the number of possible 3D shapes and allows us to attain specific topologies. An experimental apparatus that allows precise control of the strain mismatch is devised. An inverse problem is posed, where starting from a given target shape, the physical parameters that make these shapes possible are determined. To show how the concept works, it focuses on circular composite plates and designs a kirigami pattern that yields a hemispherical structure. The analysis combines a theoretical approach with numerical simulations and physical experiments to understand and predict the shape transition from 2D to 3D. The tools developed here can be extended to attain arbitrary 3D shapes. The initially flat shape suggests that conventional additive manufacturing techniques can be used to functionalize the soft kirigami composite to fabricate, for example, deployable 3D structures, smart skins, and soft electromagnetic metasurfaces.
Measuring Vascular Graft Cellularity Non‐Destructively: Merging Magnetic Resonance Imaging and Tissue Engineering
Authors: Tornifoglio Brooke , Stone Alan J. , Mathieu Pattie , Fitzpatrick Emma , Kerskens Christian , Lally Caitríona 
Published: November 2023

AbstractDespite significant growth in the field of tissue engineering over the past decades, non‐invasive, non‐destructive methods to characterize the cellularisation of grafts are lacking. Here, in a proof‐of‐concept study, a non‐invasive magnetic resonance imaging method, diffusion tensor imaging (DTI), within acellular and cellularised vascular grafts is investigated. Using decellularised porcine carotid grafts, smooth muscle cells are cultured dynamically for two weeks with terminal time points at day 3, 7, and 14. Grafts are fixed at each time point and investigated by DTI in an ex vivo set up. Semi‐quantitative histology is used as a ground truth for collagen, elastin, and cell density changes over time. DTI‐derived metrics, namely the fractional anisotropy, mean diffusivity, and tractography, are significantly different between day 3 and day 7 grafts and distinguish between acellular and cellularised grafts. Specifically, increasing fractional anisotropy is correlated to increasing cell density. The results from this study show the potential of MR‐DTI in the field of tissue engineering, offering non‐invasive, non‐destructive insight into graft cellularisation.
Nanoscale Phase Separations for Versatile Synthesis of Centimeter‐Sized Hierarchically Mesoporous Metal‐Oxide Films
Authors: Jing Jie , Zhu Kerun , Wang Shun , Gao Yihan , Dong Angang , Yang Dong , Nie Zhihong , Zhang Wei 
Published: November 2023

Hierarchically porous metal‐oxide materials have immense potential for many fields, which are highly desired to tackle the limitations of mono‐porous architectures, and to combine the advantages of different pore scales. Herein, a simple small‐molecule‐assisted interfacial assembly strategy, which elegantly combines the mesoscale block copolymers (BCPs)‐directed coassembly and nanoscale phase separations of dicyandiamide (DCDA), is developed for the synthesis of centimeter‐sized inorganic metal‐oxide films with multiscale porosity. The synthetic approach is versatile and can be broadly applied for the fabrication of hierarchically mesoporous metal‐oxide films with single (TiO2, ZrO2, Al2O3) or binary components (TiO2–ZrO2 and TiO2–Al2O3) on various substrates ranging from 1D to 3D. The as‐prepared films possess ordered structures, uniform thickness, interconnected pores, highly crystallized frameworks, and high surface areas (>200 m2 g−1). As a proof of concept, the photoelectric device assembled by the hierarchically mesoporous TiO2 films (denoted as H–TiO2) shows excellent performance, including a high photocurrent of 0.68 mA cm−2 and outstanding stability. The presented method may provide new insight into the controllable synthesis of hierarchically porous materials.
Construction of Polyheterocyclic Skeletons through C−H Bond Activation‐Initiated Cascade Reactions by Using Cyclopropanol as Alkylating Agent as well as Masked Nucleophile and Electrophile
Authors: Yang Xueying , Cai Xinyuan , Zhang Xinying , Fan Xuesen 
Published: November 2023

AbstractPresented herein is a synthesis of indane fused bicyclic pyrazolidinones based on the reactions of aryl azomethine imines with cyclopropanols. Mechanistically, the formation of product involves Rh(III)‐catalyzed direct aryl C(sp2)−H alkylation of aryl azomethine imine with cyclopropanol through in situ ring‐opening, followed by cascade intramolecular C‐ and N‐nucleophilic addition. In this tandem process, cyclopropanol acts as not only an alkylating agent but also masked nucleophile and electrophile to participate in the construction of both the indane and the bicyclic pyrazolidinone scaffolds. To our knowledge, such a cascade reaction pattern has not been disclosed. In general, this synthetic protocol has advantages such as easily obtainable substrates, valuable products, concise synthetic procedure, unique reaction pathway, and good compatibility with diverse functional groups.
Bioactive Cellulose Nanopapers Impregnated with Cinnamon Essential Oil for Sustainable Antibacterial Packaging and Extended Shelf Life of Coriander Leaves
Authors: K. V. Neenu , Begum P. M. Sabura , Kumar Aswathy V. , Kanoth Bipinbal Parambath , Sankar Sameera , Parameswaranpillai Jyotishkumar , Badawi Michael , Dominic C D Midhun 
Published: November 2023

AbstractThis study introduces a novel approach by developing cellulose nanopapers derived from pineapple pomace and impregnated with cinnamon essential oil (CEO) in the range of 1–5 wt.%. This innovative material aims to enhance the shelf life of coriander leaves through antibacterial packaging. Comparative analyses encompassed structural, crystalline, morphological, physico‐mechanical, water barrier, permeability, and antibacterial properties against control samples. Incorporating CEO yielded a reduction in crystallinity index and tensile strength, attributed to a plasticizing effect. The addition of 5 wt.% CEO led to a remarkable 46% increase in elongation at break. Enhanced thermal stability, with a Tmax rise of 26 °C, is attributed to hydrogen bonding between CEO and cellulose molecules. The nanopapers exhibited notable reductions in oxygen and water vapor transmission rates (24% and 32% respectively) compared to control nanopapers. Impressive antibacterial activity against S. aureus and E. coli is observed. These developed nanopapers are applied as active packaging for coriander leaves, extending their shelf life by up to 3 and 15 days without and with refrigeration. Moreover, chlorophyll, carotenoid, and moisture content in coriander leaves stored with CEO‐loaded nanopapers remained akin to fresh leaves. Thus, this study presents an environmentally friendly antibacterial packaging solution with potential for sustainable application.
Simultaneous ozone and hydrogen peroxide electrosynthesis via defect modulation in Ni, Sb‐doped SnO2 electrocatalysts
Authors: Ding Lei , Li Wenwen , Xue Mingzhe , Peng Xiaoge , Shi Huaijie , Liu Jia , Wang Xiaosa , Jiang Chenghang , Xue Yufeng , Wang Shibin , Zhong Xing , Wang Jianguo 
Published: November 2023

AbstractElectrochemical synthesis of green oxidants O3 and H2O2 is valuable for applications, but challenges persist in enhancing the O3 and H2O2 generation activity and combined application. Herein, we modulate the surface Ni active sites and oxygen vacancy defects content in Ni‐Sb‐SnO2 electrocatalysts to enhance selectivity for electrochemical ozone generation (EOP) and two‐electron electrochemical oxygen reduction reactions (2e− ORR). The Ni active sites and oxygen vacancy defects enriched electrocatalysts resulting in an ozone faradaic efficiency of 48.1%, while non‐enriched electrocatalyst obtained 90% selectivity for H2O2. Theoretical calculations revealed that Ni‐Sb‐SnO2 efficiently captures O2 with defective Ovac2 stabilize intermediates, facilitating O3 and H2O2 synthesis. Moreover, concerted EOP and 2e− ORR enable concurrent generation of O3 and H2O2 for efficient synergistic degradation of organic pollutants, while attenuating the energy demands of the electrolyzer. This study provides an appealing strategy for simultaneous production of O3 and H2O2 with applications in wastewater treatment.
Eine allgemeine Strategie zur Synthese von nanostrukturierten leitfähigen MOFs aus isolierenden MOF‐Vorläufern für Superkondensatoren und chemiresistive Sensoren
Authors: Huang Chuanhui , Sun Weiming , Jin Yingxue , Guo Quanquan , Mücke David , Chu Xingyuan , Liao Zhongquan , Chandrasekhar Naisa , Huang Xing , Lu Yang , Chen Guangbo , Wang Mingchao , Liu Jinxin , Zhang Geping , Yu Minghao , Qi Haoyuan , Kaiser Ute , Xu Gang , Feng Xinliang , Dong Renhao 
Published: November 2023

AbstractZweidimensionale konjugierte metallorganische Gerüstverbindungen (2D c‐MOFs) entwickeln sich zu einer einzigartigen Unterklasse von geschichteten kristallinen Koordinationspolymeren, die gleichzeitig Porosität und elektrische Leitfähigkeit besitzen und ein breites Anwendungspotenzial in Energiespeicherung und elektronischen Geräten haben. Um die intrinsischen elektronischen Eigenschaften und strukturellen Besonderheiten von 2D c‐MOFs optimal nutzen zu können, ist die kontrollierte Synthese von hierarchisch nanostrukturierten 2D c‐MOFs mit hoher Kristallinität und maßgeschneiderten Morphologien unerlässlich, was eine große Herausforderung darstellt. In diesem Artikel stellen wir eine Template‐Strategie zur Synthese einer Bibliothek von 2D c‐MOFs mit kontrollierten Morphologien und Dimensionen über eine Transformation von isolierenden MOFs zu c‐MOFs vor. Die daraus resultierenden hierarchisch nanostrukturierten 2D c‐MOFs weisen höhere intrinsische elektrische Leitfähigkeiten und größere Oberflächen als die literaturbeschriebenen 2D c‐MOFs auf, was für einen verbesserten Zugang zu aktiven Seiten und einen verbesserten Massentransport von Vorteil ist. Als Proof‐of‐Concept‐Anwendungen zeigen die hierarchisch nanostrukturierten 2D c‐MOFs eine überlegene Leistung für Anwendungen welche auf ihren elektrischen Eigenschaften basieren (hohle Cu‐BHT‐Nanowürfel‐basierte Superkondensatoren und Cu‐HHB Nanoblumen‐basierte chemiresistive Gassensoren). Diese erreichen eine Verbesserung der spezifischen Kapazität und der Ansprechintensität von über 225 % bzw. 250 % gegenüber den entsprechenden durch Bulk‐Synthese erhaltenen c‐MOFs.
Sculpting Mesoscopic Helical Chirality into Covalent Organic Framework Nanotubes from Entirely Achiral Building Blocks
Authors: Zha Xinlin , Xu Guilin , Khan Niaz Ali , Yan Zhong , Zuo Mengjuan , Xiong Yi , Liu Ying , You Haining , Wu Yi , Liu Ke , Li Mufang , Wang Dong 
Published: November 2023

AbstractThe diversification of chirality in covalent organic frameworks (COFs) holds immense promise for expanding their properties and functionality. Herein, we introduce an innovative approach for imparting helical chirality to COFs and fabricating a family of chiral COF nanotubes with mesoscopic helicity from entirely achiral building blocks for the first time. We present an effective 2,3‐diaminopyridine‐mediated supramolecular templating method, which facilitates the prefabrication of helical imine‐linked polymer nanotubes using unprecedented achiral symmetric monomers. Through meticulous optimization of crystallization conditions, these helical polymer nanotubes are adeptly converted into imine‐linked COF nanotubes boasting impressive surface areas, while well preserving their helical morphology and chiroptical properties. Furthermore, these helical imine‐linked polymers or COFs could be subtly transformed into corresponding more stable and functional helical β‐ketoenamine‐linked and hydrazone‐linked COF nanotubes with transferred circular dichroism via monomer exchange. Notably, despite the involvement of covalent bonding breakage and reorganization, these exchange processes overcome thermodynamic disadvantages, allowing mesoscopic helical chirality to be perfectly preserved. This research highlights the potential of mesoscopic helicity in conferring COFs with favourable chiral properties, providing novel insights into the development of multifunctional COFs in the field of chiral materials chemistry.
Lichtinduzierte Polymerisation katalysiert durch Kohlenstoff‐Nanomaterialien
Authors: Luo Xiongfei , Zhai Yingxiang , Wang Ping , Tian Bing , Liu Shouxin , Li Jian , Yang Chenhui , Strehmel Veronika , Li Shujun , Matyjaszewski Krzysztof , Yilmaz Gorkem , Strehmel Bernd , Chen Zhijun 
Published: November 2023

AbstractKohlenstoffnanomaterialien insbesondere Kohlenstoffpunkte und Kohlenstoffnitride spielen als heterogene Photoinitiatoren sowohl in radikalischen als auch in kationischen Polymerisationsprozessen eine besondere Rolle. Diese kürzlich eingeführten Materialien stellen herausragende Lösungen im Hinblick auf die Grenzen der gegenwärtigen homogenen Systeme dar und zeigen eine neue Herangehensweise für die Photopolymerisation. Dieser Übersichtsartikel stellt die Herstellung und die photokatalytische Leistungsfähigkeit dieser Nanomaterialien in den Mittelpunkt und hebt ihre Anwendung in verschiedenen Polymerisationstechniken einschließlich der photoinduzierten a) freien radikalischen, b) RAFT, c) ATRP und d) kationischen Polymerisation hervor. Außerdem diskutiert er deren Potential im Hinblick auf die gegenwärtigen Herausforderungen und erläutert Perspektiven auf diesem Gebiet. Darüber hinaus zeigen insbesondere Kohlenstoffnitride eine außergewöhnliche Sauerstofftoleranz, was für radikalische Polymerisationsprozesse von besonderer Bedeutung ist und Anwendungen wie beispielsweise den 3D Druck, Oberflächemodifizierungen von Überzügen und die technische Entwicklung von Hydrogelen erlaubt.
Wide‐Range Color‐Tunable Organic Scintillators for X‐Ray Imaging Through Host‐Guest Doping
Authors: Wang Hailan , Peng Chenxi , Chen Minghong , Xiao Yuxin , Zhang Tiantian , Liu Xiaowang , Chen Qiushui , Yu Tao , Huang Wei 
Published: November 2023

AbstractWith the increasing demands of X‐ray detection and medical diagnosis, organic scintillators with intense and tunable X‐ray excited emission have been becoming important. To guarantee the X‐ray absorption, heavy atoms were widely added in reported organic scintillators, which led to emission quenching. In this work, we propose a new strategy to realize organic scintillators through the host‐guest doping strategy. Then the X‐ray absorption centers (host) and emission centers (guest) are separated. Under X‐ray excitation, these materials displayed intense and readily tunable emissions ranging from green (520 nm) to near infrared (NIR) regions (682 nm). Besides, the relationship between the X‐ray absorption and spatial arrangement of the heavy atoms in the host matrix was also revealed. The potential application of these wide‐range color tunable organic host‐guest scintillators in X‐ray imaging were demonstrated. This work provides a new feasible strategy for constructing high‐performance organic scintillators with tunable luminescence properties.
Light‐Mediated Polymerization Catalyzed by Carbon Nanomaterials
Authors: Luo Xiongfei , Zhai Yingxiang , Wang Ping , Tian Bing , Liu Shouxin , Li Jian , Yang Chenhui , Strehmel Veronika , Li Shujun , Matyjaszewski Krzysztof , Yilmaz Gorkem , Strehmel Bernd , Chen Zhijun 
Published: November 2023

AbstractCarbon nanomaterials, specifically carbon dots and carbon nitrides, play a crucial role as heterogeneous photoinitiators in both radical and cationic polymerization processes. These recently introduced materials offer promising solutions to the limitations of current homogeneous systems, presenting a novel approach to photopolymerization. This review highlights the preparation and photocatalytic performance of these nanomaterials, emphasizing their application in various polymerization techniques, including photoinduced i) free radical, ii) RAFT, iii) ATRP, and iv) cationic photopolymerization. Additionally, it discusses their potential in addressing contemporary challenges and explores prospects in this field. Moreover, carbon nitrides, in particular, exhibit exceptional oxygen tolerance, underscoring their significance in radical polymerization processes and allowing their applications such as 3D printing, surface modification of coatings, and hydrogel engineering.
Guidelines in Practice: Medication Safety
Authors: Speth Jennifer 
Published: November 2023

ABSTRACTMedication errors are preventable events that health care professionals, consumers, and medication manufacturers report to the US Food and Drug Administration. The agency receives more than 100,000 medication‐related reports each year, and some reports involve patient death. A variety of sources provide perioperative nurses with information on interventions and practices to prevent medication errors, including the US Pharmacopeia, The Joint Commission, medication manufacturers’ instructions for use, safety data sheets, and the updated AORN “Guideline for medication safety.” This article provides an overview of the guideline and discusses recommendations for organizational oversight, procurement and storage, retrieval and preparation, labeling, and hazardous medications. It also includes a scenario that illustrates perioperative nursing practices for administering an antineoplastic medication intraoperatively. Perioperative nurses should review the guideline in its entirety and implement recommendations in operative or procedural settings.
Effect of fluorescent brighteners on the insecticidal activity of Bacillus thuringiensis var. kurstaki and LdMNPV on Lymantria dispar asiatica in Korea
Authors: Mezione de Carvalho Lucas , Hwang Hwal‐Su , Lee Kyeong‐Yeoll 
Published: November 2023

AbstractStilbene‐based fluorescent brighteners (FBs) have been demonstrated to improve the insecticidal activities of entomopathogenic viruses; however, there is limited information regarding their effect on entomopathogenic bacteria. We conducted this study to investigate the effect of two FBs (FB 28 and FB 71) on the insecticidal activities of Bacillus thuringiensis var. kurstaki (Btk) and Lymantria dispar multiple nuclear polyhedrosis virus (LdMNPV) on Lymantria dispar asiatica. FB 28 and Btk combination at low concentration (1.6 × 102 IU/mL) increased the mortality, whereas FB 71 and Btk combination at intermediate and high concentrations (1.6 × 103 and 1.6 × 104 IU/mL) slightly reduced the mortality compared with that with Btk alone. The lethal time was also shorter with combinations of Btk and FB 28 than with FB 71. Both FB 28 and FB 71 increased the mortality in combination with LdMNPV at all concentrations (3 × 102, 3 × 104, and 3 × 106  polyhedral occlusion bodies/mL compared with that with LdMNPV alone. Our results suggest that FBs improve the insecticidal activities of Btk and LdMNPV, and their activities depend on their interactions with the midgut structures of the host insect species.
Emerging green synthetic routes for thiazole and its derivatives: Current perspectives
Authors: Patel Maitri , Bambharoliya Tushar , Shah Drashti , Patel Krina , Patel Mehul , Shah Umang , Patel Swayamprakash , Mahavar Anjali , Patel Ashish 
Published: November 2023

AbstractThis review article provides an overview of the green synthesis of thiazole derivatives, emphasizing sustainable and environmentally friendly methodologies. Thiazole derivatives possess significant value and find diverse applications across various fields. However, conventional synthesis methods often involve hazardous reagents and generate substantial waste, posing environmental concerns. The green synthesis of thiazole derivatives employs renewable starting materials, nontoxic catalysts, and mild reaction conditions to minimize environmental impact. Innovative techniques such as microwave irradiation, ultrasound synthesis, green solvents, a green catalyst‐based approach, and mechanochemistry‐mediated synthesis are employed, offering advantages in terms of scalability, cost‐effectiveness, and purification simplicity. The resulting thiazole derivatives exhibit comparable or enhanced biological activities, showcasing the feasibility and practicality of green synthesis in drug discovery. This review paper underscores the importance of sustainable approaches in functional molecular synthesis and encourages further research in this domain.