bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bionic Mineralized 3D‐Printed Scaffolds with Enhanced In Situ Mineralization for Cranial Bone Regeneration
Authors: Wang Ling , Li Dongxuan , Huang Yawen , Mao Ruiqi , Zhang Boqing , Luo Fengxiong , Gu Peiyang , Song Ping , Ge Xiang , Lu Jian , Yang Xusheng , Fan Yujiang , Zhang Xingdong , Wang Kefeng 
Published: October 2023

AbstractIn situ mineralization is a promising strategy to mimic the physicochemical properties of biominerals and is widely applied in the field of bone repair. Given the high requirement for substance exchange in cranial bone regeneration, in situ mineralized organic–inorganic hybrid materials exhibit advantages. However, the integration of remarkable mineral content, mechanical properties, and osteogenic properties also remains a major challenge. Herein, enhanced in situ mineralization through combining the enzymatic and anion‐boosted mineralization is applied to promote the mineralization efficiency, mineral content, and mechanical properties. Based on the results of computational calculations and in vitro mineralization experiments, the mechanism of mineralization enhancement is investigated from the perspectives of nucleation sites and the saturation of in situ mineralization. Anionic polyaspartic acid (pAsp) can increase the saturation of in situ mineralization; enzymatic mineralization shows high efficiency, with minerals of low crystallinity. The changes in the properties of the minerals effectively enhance the biological properties of 3D‐printed scaffolds, as confirmed by cell proliferation/differentiation experiments in vitro and in cranial bone regeneration in vivo. This strategy provides a new thinking for the preparation of bionic mineralized scaffolds for cranial bone repair, and can greatly promote the efficiency of bone regeneration.
Active Site Engineering in Reticular Covalent Organic Frameworks for Photocatalytic CO2 Reduction
Authors: Rath Bibhuti Bhusan , Krause Simon , Lotsch Bettina Valeska 
Published: October 2023

AbstractPhotochemical CO2 reduction using ubiquitous sunlight akin to natural photosynthesis is an effective approach for conversion of renewable energy into useful chemical feedstock. Driven by the need for earth‐abundant, inexpensive, and sustainable photocatalysts with practical applicability, covalent organic frameworks (COFs) have emerged as a new generation of molecularly defined semiconductors with tunable optoelectronic properties. These reticular frameworks with highly ordered, porous and crystalline structures can be tailor‐made by covalently combining organic building blocks to target specific functions. To date, numerous COFs have been reported, which show promising activity for photocatalytic CO2 reduction allowing to derive structure–property–function relationships. In this review, the different reported strategies are comprehensively analyzed and categorized for active site engineering in COF photocatalysts and the synthetic rationale and resulting catalytic activity for each approach are discussed. The recent advancements in terms of tailored photocatalyst design are then critically assessed, aspects of advanced materials characterization are analyzed, and future perspectives and challenges for the field are highlighted.
Insertion of Urea Moieties for One‐Component Strong yet Tough, Self‐Healing Polyurea Protective Materials
Authors: Zhang Zhipeng , Qian Lu , Huang Guanyu , Chen Cong , Cheng Jianfeng , Yao Xiaohu , Ma Chunfeng , Zhang Guangzhao 
Published: October 2023

AbstractPolyurea has gained increasing attention in civil engineering, flexible electronics, and other emerging fields. However, owing to the rapid polymerization, tailoring their mechanical properties of polyurea for different applications remains challenging. Herein, a novel strategy is proposed for the insertion of urea moieties to prepare one‐component robust, mechanically tunable, and healable polyurea. First, the prepared latent curing agent, isophorone diisocyanate (IPDI), and NCO‐terminated prepolymer (PPGTD) are mixed. Due to the large difference in the reactivity of the ─NCO groups in IPDI and PPGTD, IPDI first reacts with the deblocked amino groups to form continuous urea moieties. The resulting urea moieties are inserted into the polyurea. This strategy provides a tremendous improvement in strength (500% increase), storage modulus (532% increase), and toughness (281% increase). Additionally, the as‐prepared polyurea exhibits excellent self‐healing, impact resistance, high transparency (>90%), and high dielectric constant (≈4.5). Thus, it can be used as a protective film and flexible substrate for electronic devices. Furthermore, the polyurea exhibits good versatility, which can be laminated with alumina ceramic sheets to form impact composites. This work opens up a promising avenue for the design and fabrication of polyurea material for flexible electronics and provides new insights into engineering anti‐impact materials.
A Dose‐Dependent Spatiotemporal Response of Angiogenesis Elicited by Zn Biodegradation during the Initial Stage of Bone Regeneration
Authors: Tan Junlong , Li Shuang , Sun Chaoyang , Bao Guo , Liu Meijing , Jing Zehao , Fu Hanwei , Sun Yanhua , Yang Qingmin , Zheng Yufeng , Wang Xiaogang , Yang Hongtao 
Published: October 2023

AbstractZinc (Zn) plays a crucial role in bone metabolism and imbues biodegradable Zn‐based materials with the ability to promote bone regeneration in bone trauma. However, the impact of Zn biodegradation on bone repair, particularly its influence on angiogenesis, remains unexplored. This study reveals that Zn biodegradation induces a consistent dose‐dependent spatiotemporal response in angiogenesis,both in vivo and in vitro. In a critical bone defect model, an increase in Zn release intensity from day 3 to 10 post‐surgery is observed. By day 10, the CD31‐positive area around the Zn implant significantly surpasses that of the Ti implant, indicating enhanced angiogenesis. Furthermore,angiogenesis exhibits a distance‐dependent pattern closely mirroring the distribution of Zn signals from the implant. In vitro experiments demonstrate that Zn extraction fosters the proliferation and migration of human umbilical vein endothelial cells and upregulates the key genes associated with tube formation, such as HIF‐1α and VEGF‐A, peaking at a concentration of 22.5 µM. Additionally, Zn concentrations within the range of 11.25−45 µM promote the polarization of M0‐type macrophages toward the M2‐type, while inhibiting polarization toward the M1‐type. These findings provide essential insights into the biological effects of Zn on bone repair, shedding light on its potential applications.
Multifunctional, Hybrid Materials Design via Spray‐Drying: Much more than Just Drying
Authors: Wintzheimer Susanne , Luthardt Leoni , Cao Kiet Le Anh , Imaz Inhar , Maspoch Daniel , Ogi Takashi , Bück Andreas , Debecker Damien P. , Faustini Marco , Mandel Karl 
Published: October 2023

AbstractSpray‐drying is a popular and well‐known “drying tool” for engineers. This perspective highlights that, beyond this application, spray‐drying is a very interesting and powerful tool for materials chemists to enable the design of multifunctional and hybrid materials. Upon spray‐drying, the confined space of a liquid droplet is narrowed down, and its ingredients are forced together upon “falling dry.” As detailed in this article, this enables the following material formation strategies either individually or even in combination: nanoparticles and/or molecules can be assembled; precipitation reactions as well as chemical syntheses can be performed; and templated materials can be designed. Beyond this, fragile moieties can be processed, or “precursor materials” be prepared. Post‐treatment of spray‐dried objects eventually enables the next level in the design of complex materials. Using spray‐drying to design (particulate) materials comes with many advantages—but also with many challenges—all of which are outlined here. It is believed that multifunctional, hybrid materials, made via spray‐drying, enable very unique property combinations that are particularly highly promising in myriad applications—of which catalysis, diagnostics, purification, storage, and information are highlighted.
Microfluidic Platforms for Real‐Time In Situ Monitoring of Biomarkers for Cellular Processes
Authors: Lou Chengming , Yang Hongru , Hou Ying , Huang Haina , Qiu Jichuan , Wang Chunhua , Sang Yuanhua , Liu Hong , Han Lin 
Published: October 2023

AbstractCellular processes are mechanisms carried out at the cellular level that are aimed at guaranteeing the stability of the organism they comprise. The investigation of cellular processes is key to understanding cell fate, understanding pathogenic mechanisms, and developing new therapeutic technologies. Microfluidic platforms are thought to be the most powerful tools among all methodologies for investigating cellular processes because they can integrate almost all types of the existing intracellular and extracellular biomarker‐sensing methods and observation approaches for cell behavior, combined with precisely controlled cell culture, manipulation, stimulation, and analysis. Most importantly, microfluidic platforms can realize real‐time in situ detection of secreted proteins, exosomes, and other biomarkers produced during cell physiological processes, thereby providing the possibility to draw the whole picture for a cellular process. Owing to their advantages of high throughput, low sample consumption, and precise cell control, microfluidic platforms with real‐time in situ monitoring characteristics are widely being used in cell analysis, disease diagnosis, pharmaceutical research, and biological production. This review focuses on the basic concepts, recent progress, and application prospects of microfluidic platforms for real‐time in situ monitoring of biomarkers in cellular processes.
Soft Wearable Haptic Display and Flexible 3D Force Sensor for Teleoperated Surgical Systems
Authors: Thai Mai Thanh , Davies James , Nguyen Chi Cong , Phan Phuoc Thien , Hoang Trung Thien , Ji Adrienne , Zhu Kefan , Sharma Bibhu , Nicotra Emanuele , Vo‐Doan Tat Thang , Phan Hoang‐Phuong , Lovell Nigel Hamilton , Do Thanh Nho 
Published: October 2023

AbstractHaptic (touch) is important for effective interaction with the surroundings. In teleoperated surgical systems, its absence leads to reduced perception, making delicate tasks difficult and resulting in unexpected damage to surrounding tissues. To enhance safety, a force‐feedback system and haptic device are needed. However, existing haptic prototypes are associated with rigid, bulky, and heavy components, making effective communication with the skin problematic. This paper presents a teleoperated endoscopic surgical system with an integrated 3D force sensor and real‐time haptic feedback. A surgical robotic arm is remotely controlled by a soft haptic glove incorporated 3‐axis cutaneous device and a finger kinesthetic module. The 3D force sensor is constructed from hydraulic filament soft sensors that can induce pressure change under strain. To enable precise motion, the haptic glove is operated by a feedforward controller and a master‐slave architecture. Experiments with human subjects (n= 15) show that cutaneous and kinesthetic feedback significantly improves the user's performance (9.4 out of 10) compared to no haptic feedback (2.27 out of 10). Finally, subjects rank the new system as highly wearable, comfortable, and effective, which is expected to bridge a gap in the surgical field and support the future development of advanced teleoperated systems.
Hybrid Bionic Nerve Interface for Application in Bionic Limbs
Authors: Cho Youngjun , Jeong Hyung Hwa , Shin Heejae , Pak Changsik John , Cho Jeongmok , Kim Yongwoo , Kim Donggeon , Kim Taehyeon , Kim Hoijun , Kim Sohee , Kwon Soonchul , Hong Joon Pio , Suh Hyunsuk Peter , Lee Sanghoon 
Published: October 2023

AbstractIntuitive and perceptual neuroprosthetic systems require a high degree of neural control and a variety of sensory feedback, but reliable neural interfaces for long‐term use that maintain their functionality are limited. Here, a novel hybrid bionic interface is presented, fabricated by integrating a biological interface (regenerative peripheral nerve interface (RPNI)) and a peripheral neural interface to enhance the neural interface performance between a nerve and bionic limbs. This interface utilizes a shape memory polymer buckle that can be easily implanted on a severed nerve and make contact with both the nerve and the muscle graft after RPNI formation. It is demonstrated that this interface can simultaneously record different signal information via the RPNI and the nerve, as well as stimulate them separately, inducing different responses. Furthermore, it is shown that this interface can record naturally evoked signals from a walking rabbit and use them to control a robotic leg. The long‐term functionality and biocompatibility of this interface in rabbits are evaluated for up to 29 weeks, confirming its promising potential for enhancing prosthetic control.
Automatic zone management definition in Mediterranean environment for Triticum durum
Authors: Orsini Roberto , Fiorentini Marco , Zenobi Stefano , Santilocchi Rodolfo , Deligios Paola A. , Ledda Luigi 
Published: October 2023

AbstractPrecision agriculture (PA) is an agronomic management that allows the parsimonious use of agronomic inputs according to the crop's actual spatiotemporal needs. The most important agronomic practice of PA is the site‐specific management (SSM) of agronomic inputs. To apply SSM, the number and location of homogeneous zones must be defined. Nowadays, many approaches are used to define the number of zones in an arbitrary and constant way, such as high‐, medium‐, and low‐input zones, without a priori statistical analysis. Two combined field experiments were carried out on durum wheat (Triticum turgidum subsp. durum Desf.) in central Italy to agronomically validate an automatic approach aimed at defining the number and position of the homogeneous zones using multispectral images. For both sites, at stem elongation and anthesis, the dry biomass per square meter and Soil Plant Analysis Development (SPAD) readings were measured, while at crop maturity the yield was measured. This approach uses multispectral images as source data and uses the gap statistic index to determine the correct number of zones. The management zones created were well‐fitted with the experimental design of both sites, and the validation was made by the statistical analysis performed on yield data, SPAD, dry biomass, and normalized difference red edge index with an average difference of 40.2%, 28.5%, 57.5%, and 37.4%, respectively, between the management zones. The approach could be scaled by using the multitemporal multispectral images provided by satellite constellation, which enables farms and societies to take advantage of all the economic and environmental benefits of PA.
Biocultural correlates of gross motor coordination in prepubescent children: A cross‐sectional study
Authors: da Silva Lima Braulio Patrick , Giudicelli Bruno Barbosa , dos Santos Pinheiro Ingrid Kelly Alves , Santos Douglas Henrique Bezerra , Magalhães Kleberton Carlos Silva , dos Santos Henrique Rafael , da Silva Danilo Rodrigues Pereira , Silva Manuel João Coelho e , de Oliveira Luz Leonardo Gomes 
Published: October 2023

AbstractAimThis study aimed to explore the association of gross motor coordination (GMC) with a matrix of biocultural factors in prepubescent children, taking into account weight status, somatic maturation, sociodemographic variables, and type of school.MethodsOne hundred twenty‐nine prepubescent children, of both sexes, aged between 8.00 and 8.99, were assessed for GMC (Körperkoordinationstest Für Kinder ‐ KTK), weight status, biological maturation (predicted mature stature), sex, mother's education level and type of school. Binary logistic regression was used to examine the relationship between higher values of KTK and associated biocultural factors.ResultsNormoponderal children are more likely to attain better total KTK scores than those with overweight or obesity (OR: 2.942; LC 95%: 1.189, 7.280). In addition, children who are more advanced in terms of biological maturation exhibited significantly lower odds of being in the high KTK category than their less advanced peers (OR: 0.670; LC 95%: 0.474,0.946). Sex, mother's education level and the type of school are not associated with higher performance on KTK.ConclusionWeight status and biological maturation are associated with motor competence in prepubescent children. Future studies should consider additional correlates to better understand the complex interactions between biological, psychosocial and behavioral factors in the prediction of motor competence.
Validation of predictive equations to estimate resting metabolic rate of females and males across different activity levels
Authors: Prado‐Nóvoa Olalla , Howard Kristen R. , Laskaridou Eleni , Reid Glen R. , Zorrilla‐Revilla Guillermo , Marinik Elaina L. , Davy Brenda M. , Speakman John R. , Davy Kevin P. 
Published: October 2023

AbstractObjectivesUsing equations to predict resting metabolic rate (RMR) has yielded different degrees of validity, particularly when sex and different physical activity levels were considered. Therefore, the purpose of the present study was to determine the validity of several different predictive equations to estimate RMR in female and male adults with varying physical activity levels.MethodWe measured the RMR of 50 adults (26 females and 24 males) evenly distributed through activity levels varying from sedentary to ultra‐endurance. Body composition was measured by dual X–ray absorptiometry and physical activity was monitored by accelerometry. Ten equations to predict RMR were applied (using Body Mass [BM]: Harris & Benedict, 1919; Mifflin et al., 1990 [MifflinBM]; Pontzer et al., 2021 [PontzerBM]; Schofield, 1985; FAO/WHO/UNU, 2004; and using Fat‐Free Mass (FFM): Cunningham, 1991; Johnstone et al., 2006; Mifflin et al., 1990 [MifflinFFM]; Nelson et al. 1992; Pontzer et al., 2021 [PontzerFFM]). The accuracy of these equations was analyzed, and the effect of sex and physical activity was evaluated using different accuracy metrics.ResultsEquations using BM were less accurate for females, and their accuracy was influenced by physical activity and body composition. FFM equations were slightly less accurate for males but there was no obvious effect of physical activity or other sample parameters. PontzerFFM provides higher accuracy than other models independent of the magnitude of RMR, sex, activity levels, and sample characteristics.ConclusionEquations using FFM were more accurate than BM equations in our sample. Future studies are needed to test the accuracy of RMR prediction equations in diverse samples.
Neonatal abstinence syndrome and other neonatal outcomes for the infants of women experiencing incarceration: A retrospective cohort study
Authors: Bell Megan F. , Kelty Erin , Segal Leonie , Dennison Susan , Kinner Stuart A. , Dawe Sharon , Spittal Matthew J. , Preen David B. 
Published: October 2023

AbstractSubstance use during pregnancy is associated with poor neonatal outcomes. Women incarcerated during pregnancy may have a history of substance use, and their babies may be at risk of neonatal abstinence syndrome (NAS). This study examines the incidence of NAS and other outcomes in infants born to currently or formerly incarcerated women. Infants born between 1985 and 2011 in Western Australia were divided into three mutually exclusive groups: born to women incarcerated during pregnancy (n = 708); born within 9–24 months of the mother's release from prison (n = 651); and born to women who were never incarcerated (n = 17,712). The impact of the timing of incarceration during pregnancy was also examined. Neonatal outcomes (NAS, preterm birth, low birthweight, infant mortality and admission to special care nursery) were compared using logistic regression. Infants born to currently or recently incarcerated women had higher odds of all adverse outcomes than infants in the nonexposed group. Infants born to women incarcerated during the second or third trimester (but not the month of birth) had poorer outcomes than infants born to women incarcerated during the month of birth. The findings show that babies born to currently or formerly incarcerated women are equally likely to experience adverse neonatal outcomes. Enhanced maternal healthcare must be provided during incarceration and after release.
Post‐Synthetic Ensembling Design of Hierarchically Ordered FAU‐type Zeolite Frameworks for Vacuum Gas Oil Hydrocracking
Authors: Kumar Parsapur Rajesh , Hengne Amol M. , Melinte Georgian , Refa Koseoglu Omer , Hodgkins Robert Peter , Bendjeriou‐Sedjerari Anissa , Lai Zhiping , Huang Kuo‐Wei 
Published: October 2023

AbstractZeolites hold importance as catalysts and membranes across numerous industrial processes that produce most of the world's fuels and chemicals. In zeolite catalysis, the rate of molecular diffusion inside the micropore channels defines the catalyst's longevity and selectivity, thereby influencing the catalytic efficiency. Decreasing the diffusion pathlengths of zeolites to the nanoscopic level by fabricating well‐organized hierarchically porous architecture can efficiently overcome their intrinsic mass‐transfer limitations without losing hydrothermal stability. We report a rational post‐synthetic design for synthesizing hierarchically ordered FAU‐type zeolites exhibiting 2D‐hexagonal (P6mm) and 3D‐cubic (Ia
d) mesopore channels. The synthesis involves methodical incision of the parent zeolite into unit‐cell level zeolitic fragments by in situ generated base and bulky surfactants. The micellar ensembles formed by these surfactant‐zeolite interactions are subsequently reorganized into various ordered mesophases by tuning the micellar curvature with ion‐specific interactions (Hofmeister effect). Unlike conventional crystallization, which offers poor control over mesophase formation due to kinetic constraints, crystalline mesostructures can be developed under dilute, mild alkaline conditions by controlled reassembly. The prepared zeolites with nanometric diffusion pathlengths have demonstrated excellent yields of naphtha and middle‐distillates in vacuum gas oil hydrocracking with decreased coke deposition.
Rapid imaging in the field followed by photogrammetry digitally captures the otherwise lost dimensions of plant specimens
Authors: James Nicole , Adkinson Alex , Mast Austin 
Published: October 2023

AbstractPremiseWe recognized the need for a customized imaging protocol for plant specimens at the time of collection for the purpose of three‐dimensional (3D) modeling, as well as the lack of a broadly applicable photogrammetry protocol that encompasses the heterogeneity of plant specimen geometries and the challenges introduced by processes such as wilting.Methods and ResultsWe developed an equipment list and set of detailed protocols describing how to capture images of plant specimens in the field prior to their deformation (e.g., with pressing) and how to produce a 3D model from the image sets in Agisoft Metashape Professional.ConclusionsThe equipment list and protocols represent a foundation on which additional improvements can be made for specimen geometries outside of the range of the six types considered, and an easy entry into photogrammetry for those who have not previously used it.