bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menthol‐Based (Deep) Eutectic Solvents: A Review on Properties and Application in Extraction
Authors: Cherniakova Marharyta , Varchenko Victoria , Belikov Konstantin 
Published: October 2023

AbstractIn the last 10 years the interest in deep eutectic solvents (DESs) as a new class of green solvents has considerably increased. The emergence of numerous of hydrophobic DESs has stimulated intensive research into their application in extraction technologies, including sample preparation. As the properties of such systems are highly dependent on the properties of their components (hydrogen bond donors and acceptors) and can be finely tuned, DESs can be successfully used for the extraction of both metal ions and organic substances, including biomolecules. Despite the rapidly increasing number of publications on the use of DESs as an extraction medium, including review articles, information on the extraction properties of DESs in terms of their chemical composition has not yet been summarized. This review covers available literature data on the physicochemical properties of menthol‐based eutectic solvents and the results of their practical application as an extraction medium. Also, the appropriateness of using the term “DES” for all mixtures with melting points lower than the melting points of their components is discussed.
Corosolic acid inhibits metastatic response of human renal cell carcinoma cells by modulating ERK/MMP2 signaling
Authors: Wu Tsai‐Kun , Hung Tung‐Wei , Chen Yong‐Syuan , Pan Ying‐Ru , Hsieh Yi‐Hsien , Tsai Jen‐Pi 
Published: October 2023

AbstractCorosolic acid (CA), a plant‐derived pentacyclic triterpenoid, has potent anti‐inflammatory, anti‐metabolic, and anti‐neoplastic actions against a variety of human cancers. However, the specific mechanism by which CA inhibits the progression of renal cell carcinoma (RCC) is yet unclear. We found that CA (≤8 μM) had no influence on either the growth or viability of RCC cell lines (786‐O, ACHN, and Caki‐1) or normal HK2 cells. However, in a dose‐dependent manner, CA prevented the invasion and migration of RCC cells. Human protease array analysis showed that CA reduced MMP2 expression. At increasing concentrations of CA, the expression of MMP2 was dose‐dependently reduced, as shown by western blot and RT‐PCR analyses as well as immunofluorescence staining. CA also stimulated ERK1/2 phosphorylation in 786‐O and Caki‐1 cells. Transfection of CA‐treated RCC cells with siRNA‐ERK restored MMP2 protein expression and the motility and invasion capabilities of RCC cells. Molecular docking study results showed that CA and MMP2 interact strongly. These findings elucidate the mechanism by which CA prevents RCC cells from migrating and invading, and these findings indicate that CA may be a potential anti‐metastatic therapy for RCC.
Airborne magnetite nanoparticles induced early vascular pathologies by disrupting lipid metabolism under high‐fat dietary patterns
Authors: Zhang Jingxu , Yu Hongyan , Pan Ruonan , Miao Gan , Wang Yu , Li Ziyuan , Yu Haiyi , Lu Lin , Jin Xiaoting 
Published: October 2023

AbstractMagnetite nanoparticles (MNPs) have been extensively detected in the atmospheric environment and implicated as a prominent threat to atherosclerosis, a chronic vascular inflammatory disease. Due to globalization and economic development, the dramatic shift in diet from traditional to high‐fat dietary patterns aggravated atherosclerosis progression induced by environmental factors. However, limited knowledge is available regarding vascular risks and underlying mechanisms of airborne MNPs in high‐risk populations with high‐fat dietary habits. Herein, we demonstrated that MNPs exerted a proatherogenic effect under high‐fat dietary patterns, leading to aortic wall thickening, elastic fiber disorganization, macrophage infiltration, and local inflammation. Based on the correlation analysis between MNPs and PM group, we identified that MNPs might be a key PM component in atherogenic toxicity. MNPs exposure disturbed the dynamic process of lipid metabolism, manifested as aortic lipid accumulation, dyslipidemia, and hepatic lipid metabolism disorder, which was modulated by the JAK–STAT pathway. Overall, these findings provide new insight into understanding the cardiovascular risks and mechanisms of MNPs among high‐risk populations.
Winkler‐Pasternak foundation effect on the buckling loads of arbitrarily rigid or restrained supported nonlocal beams made of different FGM and porosity distributions
Authors: Uzun Büşra , Yaylı Mustafa Özgür 
Published: October 2023

AbstractThe present research investigates lateral stability of a functionally graded nanobeam using Eringen's differential nonlocal elasticity model under rigid (clamped, pinned, free) and deformable (lateral, rotational restraints) boundary conditions. Sigmoid and power law have been employed as grading laws to study the influence of the material distribution on the snap‐buckling analysis of a nanobeam with arbitrary boundary conditions. Moreover, Fourier sine series with Stokes’ transformation are employed to investigate the effects of boundary conditions on the stability response of nanobeams embedded in a Pasternak foundation. A parametric study has been performed to investigate the effect of deformable boundaries, Pasternak foundation and small‐scale parameters on the stability response of the nanobeam and the results have been presented in a series of tables and figures. It has been observed that consideration of the small‐scale parameter, Pasternak foundation, deformable boundaries and functionally grading index (of sigmoid and power‐law) are essential while analyzing the static stability response. The obtained analytical results may be used as benchmarks in future researches of functionally graded nanobeams embedded in an elastic medium.
Remarks on a linearization of Koopmans recursion
Authors: Zdun Marek Cezary 
Published: October 2023

AbstractLet X be a metric space and $$U:X^{\infty }\rightarrow \mathbb {R}$$

U
:

X
∞

→
R

be a continuous function satisfying the Koopmans recursion $$U(x_0,x_1,x_2,\ldots )=\varphi (x_0, U(x_1,x_2,\ldots )),$$

U

(

x
0

,

x
1

,

x
2

,
…
)

=
φ

(

x
0

,
U

(

x
1

,

x
2

,
…
)

)

,

where $$\varphi :X\times I \rightarrow I$$

φ
:
X
×
I
→
I

is a continuous function and I is an interval. Denote by $$\succeq $$
⪰
a preference relation defined on the product $$X^{\infty }$$

X
∞

represented by a function $$U:X^{\infty }\rightarrow \mathbb {R}$$

U
:

X
∞

→
R

, called a utility function, that means $$(x_0,x_1,\ldots )\succeq (y_0,y_1,\ldots )\Leftrightarrow U(x_0,x_1,\ldots )\ge U(y_0,y_1,\ldots )$$

(

x
0

,

x
1

,
…
)

⪰

(

y
0

,

y
1

,
…
)

⇔
U

(

x
0

,

x
1

,
…
)

≥
U

(

y
0

,

y
1

,
…
)

. We consider a problem when the preference relation $$\succeq $$
⪰
can be represented by another utility function V satisfying the affine recursion $$V(x_0,x_1,x_2,\ldots ) = \alpha (x_0)V(x_1,x_2,\ldots )+ \beta (x_0)$$

V

(

x
0

,

x
1

,

x
2

,
…
)

=
α

(

x
0

)

V

(

x
1

,

x
2

,
…
)

+
β

(

x
0

)

. Under suitable assumptions on relation $$\succeq $$
⪰
we determine the form of the functions $$\varphi $$
φ
defining the utility functions possessing the above property. The problem is reduced to solving a system of simultaneous functional equations. The subject is strictly connected to a problem of preference in economics. In this note we extend the results obtained in Zdun (Aequ Math 94, 2020).
Changes in antimony isotopic composition as a tracer of hydrothermal fluid evolution at the Sb deposits in Pezinok (Slovakia)
Authors: Kaufmann Andreas B. , Lazarov Marina , Weyer Stefan , Števko Martin , Kiefer Stefan , Majzlan Juraj 
Published: October 2023

AbstractIn this work, we investigated in situ isotopic compositions of antimony (Sb) minerals from two substages of the ore deposits near Pezinok (Slovakia). The δ123Sb values of the primary Sb minerals range from −0.4 and +0.8‰ and increase progressively along the precipitation sequence. In the substage II, the early-formed gudmundite (FeSbS) shows in all sections the lowest δ123Sb values, followed by berthierite (FeSb2S4), stibnite (Sb2S3), and valentinite (Sb2O3) with the heaviest δ123Sb values. A similar trend was observed for the substage III, from the initially-formed stibnite, followed by kermesite (Sb2S2O), valentinite, senarmontite (both Sb2O3), and schafarzikite (FeSb2O4). The evolution can be rationalized by a Rayleigh fractionation model with a starting δ123Sb value in the fluid of +0.3‰, applying the same mineral-fluid fractionation factor to all minerals. Thus, the texturally observed order of mineralization is confirmed by diminishing trace element contents and heavier δ123Sb values in successively crystallized Sb minerals. Antimony in substage III was likely supplied from the oxidative dissolution of stibnite that formed earlier during substage II. The data interpretation, although limited by the lack of reliable mineral-fluid fractionation factors, implies that Sb precipitation within each substage occurred from an episodic metal precipitation, likely associated with a similar Sb isotope fractionation between fluid and all investigated Sb minerals. Large isotopic variations, induced by precipitation from a fluid as a response to temperature decrease, may be an obstacle in deciphering the metal source in hydrothermal ore deposits. However, Sb isotopes appear to be an excellent instrument to enhance our understanding on how hydrothermal systems operate.
Risk and protective factors for recovery at 3-year follow-up after first-episode psychosis onset: a multivariate outcome approach
Authors: Serra-Arumí Clara , Golay Philippe , Bonnarel Vincent , Alerci Livia , Abrahamyan Empson Lilith , Conus Philippe , Alameda Luis 
Published: October 2023

Abstract
Purpose
Recovery in people with first-episode psychosis (FEP) remains a major issue. When risk factors are studied in relation to the disorder, potential protective factors should also be considered since they can modulate this relationship. This study is aimed at exploring which premorbid and baseline characteristics are associated with a good and poor global recovery in patients with FEP at 3-year follow-up.

Methods
We categorized patients’ outcome by using a Latent Class Analysis (LCA) considering a multimodal set of symptomatic and functional outcomes. A Mixed effects Models Repeated Measures analysis of variance (MMRM) was used to highlight group differences over time on symptomatic and functional outcomes assessed during the 3-year follow-up.

Results
A total of 325 patients with FEP aged between 18 and 35 years were included. Two groups were identified. A total of 187 patients (57.5%) did not achieve recovery, and 138 patients (42.5%) achieved recovery. Recovered patients had generally a better premorbid and baseline profile in comparison with non-recovered patients (as among which shorter duration of untreated psychosis (DUP), higher degree of insight, better functional level and lower illness severity at baseline). The trajectories for the psychopathological and functional outcomes over 36 months differed between the non-recovered and the recovered group of patients.

Conclusions
Our results pointed to some variables associated with recovery, acting as potential protective factors. These should be considered for early intervention programs to promote psychological resilience specifically in those with a worse prognosis in order to mitigate the effects of the variables that make them more vulnerable to poorer outcome.
The effect of governance structures on optimal control of two-patch epidemic models
Authors: Howerton Emily , Dahlin Kyle , Edholm Christina J. , Fox Lindsey , Reynolds Margaret , Hollingsworth Brandon , Lytle George , Walker Melody , Blackwood Julie , Lenhart Suzanne 
Published: October 2023

AbstractInfectious diseases continue to pose a significant threat to the health of humans globally. While the spread of pathogens transcends geographical boundaries, the management of infectious diseases typically occurs within distinct spatial units, determined by geopolitical boundaries. The allocation of management resources within and across regions (the “governance structure”) can affect epidemiological outcomes considerably, and policy-makers are often confronted with a choice between applying control measures uniformly or differentially across regions. Here, we investigate the extent to which uniform and non-uniform governance structures affect the costs of an infectious disease outbreak in two-patch systems using an optimal control framework. A uniform policy implements control measures with the same time varying rate functions across both patches, while these measures are allowed to differ between the patches in a non-uniform policy. We compare results from two systems of differential equations representing transmission of cholera and Ebola, respectively, to understand the interplay between transmission mode, governance structure and the optimal control of outbreaks. In our case studies, the governance structure has a meaningful impact on the allocation of resources and burden of cases, although the difference in total costs is minimal. Understanding how governance structure affects both the optimal control functions and epidemiological outcomes is crucial for the effective management of infectious diseases going forward.
Obesity in prenatal medicine: a game changer?
Authors: Prodan Natalia Carmen , Schmidt Markus , Hoopmann Markus , Abele Harald , Kagan Karl Oliver 
Published: October 2023

AbstractObesity is recognized by the World Health Organization (WHO) as a disease in its own right. Moreover, obesity is an increasingly concerning public health issue across the world and its prevalence is rising amongst women of reproductive age. The fertility of over-weight and obese women is reduced and they experience a higher rate of miscarriage. In pregnant women obesity not only increases the risk of antenatal complications, such as preeclampsia and gestational diabetes, but also fetal abnormalities, and consequently the overall feto-maternal mortality. Ultrasound is one of the most valuable methods to predict and evaluate pregnancy complications. However, in overweight and obese pregnant women, the ultrasound examination is met with several challenges, mainly due to an impaired acoustic window. Overall obesity in pregnancy poses special challenges and constraints to the antenatal care and increases the rate of pregnancy complications, as well as complications later in life for the mother and child.
Impact of different fracture types in the pyriform buttress area on nasal airway function
Authors: Wang Zhongying , Chen Dong 
Published: October 2023

Abstract
Introduction
Fractures in the pyriform buttress area adversely affect facial appearance and nasal airway patency. Nasal airway function has received less attention than aesthetic problems in the literature. This retrospective study classified the different fracture types in this area and determined their impact on nasal airway function.

Mathods
Three-dimensional computed tomography images of patients with fractures in the pyriform buttress area were analyzed to identify the exact fracture pattern. The nasal airway functions were evaluated and compared between patients with different fracture patterns using acoustic rhinometry, rhinomanometry, and the nasal obstruction symptom evaluation scale.

Results
Overall, 47 patients, including 16 with type I fractures (high fracture line; group I), 16 with type II fractures (intermediate fracture line; group II), and 15 with type III fractures (low fracture line; group III), were included in the study. The mean minimal cross-sectional area (MCA), total nasal inspiratory resistance (Tri) and total nasal expiratory resistance (Tre) of group I were 0.51 ± 0.06 cm2, 1.67 ± 0.11 kPa L−1 s−1, and 1.66 ± 0.12 kPa L−1 s−1, respectively; those of group II were 0.48 ± 0.07 cm2, 1.89 ± 0.15 kPa L−1 s−1, and 1.88 ± 0.14 kPa L−1 s−1, respectively; and those of group III were 0.36 ± 0.04 cm2, 1.94 ± 0.21 kPa L−1 s−1, and 2.01 ± 0.34 kPa L−1 s−1, respectively. The nasal obstruction symptom evaluation (NOSE) scale scores for groups I, II, and III were 7.188, 9.813, and 13.27, respectively.

Conclusion
Therefore, the severity of the nasal airway obstruction depends on the displacement of the fractured bones in patients with fractures in the pyriform buttress area. The most profound nasal obstruction occurs in patients with the lowest fracture line.
Different cortical connectivities in human females and males relate to differences in strength and body composition, reward and emotional systems, and memory
Authors: Zhang Ruohan , Rolls Edmund T. , Cheng Wei , Feng Jianfeng 
Published: October 2023

AbstractSex differences in human brain structure and function are important, partly because they are likely to be relevant to the male–female differences in behavior and in mental health. To analyse sex differences in cortical function, functional connectivity was measured in 36,531 participants (53% female) in the UK Biobank (mean age 69) using the Human Connectome Project multimodal parcellation atlas with 360 well-specified cortical regions. Most of the functional connectivities were lower in females (Bonferroni corrected), with the mean Cohen’s d =  − 0.18. Removing these as covariates reduced the difference of functional connectivities for females—males from d =  − 0.18 to − 0.06. The lower functional connectivities in females were especially of somatosensory/premotor regions including the insula, opercular cortex, paracentral lobule and mid-cingulate cortex, and were correlated with lower maximum workload (r = 0.17), and with higher whole body fat mass (r =  − 0.17). But some functional connectivities were higher in females, involving especially the ventromedial prefrontal cortex and posterior cingulate cortex, and these were correlated with higher liking for some rewards such as sweet foods, higher happiness/subjective well-being, and with better memory-related functions. The main findings were replicated in 1000 individuals (532 females, mean age 29) from the Human Connectome Project. This investigation shows the cortical systems with different functional connectivity between females and males, and also provides for the first time a foundation for understanding the implications for behavior of these differences between females and males.
Coping and vegetative reactivity in uveal melanoma
Authors: Gabriel Maximilian , Trapp Eva-Maria , Rohrer Peter , Trapp Michael , Schwantzer Gerold , Mester Amalia , Richtig Erika , Schwab Christoph , Langmann Gerald , Egger Josef , Mayer-Xanthaki Christoph 
Published: October 2023

Summary
Background
We aimed to assess coping and vegetative reactivity in uveal melanoma (UM) patients compared to controls with benign nevi of the uvea.

Material and methods
In total, 20 patients with recently diagnosed uveal melanoma were recruited and matched for age and gender to 20 controls with benign nevi of the uvea. Heart rate variability (HRV) and blood pressure variability (BPV) were monitored throughout an initial period of rest (POR1), a mental stress test (DT), and another period of rest (POR2). Coping strategies were assessed for both groups using a stress-coping questionnaire.

Results
The LF/HF ratio (low-/high-frequency component of total spectral power) of HRV showed decreasing values in the UM group and increasing values in controls throughout the measurement sequence (p = 0.025). Diastolic BPV revealed declining values of the low-frequency component in normalized units (LFnu) between POR1 and DT in UM patients compared to rising values between POR1 and DT in controls (p = 0.006). There were no intergroup differences in coping strategies (p > 0.05).

Conclusions
Coping mechanisms are unaltered in patients with uveal melanoma compared to controls, but vegetative reactivity may show a different pattern once patients are diagnosed.
Senior volunteers: addressing loneliness in times of COVID-19
Authors: Torres Zaira , Martínez-Gregorio Sara , Oliver Amparo 
Published: October 2023

AbstractVolunteering in old age plays an important role in addressing feelings of loneliness, but little research has been conducted on the impact of engaging in volunteering activities during the COVID-19 pandemic. This study investigates the longitudinal impact of volunteering on feelings of loneliness. We analyzed data from 31,667 adults aged 50 years and older in the Survey of Health, Ageing and Retirement in Europe (SHARE), across three consecutive waves (one before the pandemic and two during the COVID-19 pandemic). Binary logistic regression analyses were conducted for loneliness, using volunteering and several control variables as independent variables, and found that even after controlling for previous loneliness, volunteering has a protective effect against experiencing feelings of loneliness. Those who participated in volunteering activities before or during the second pandemic period had a lower risk of loneliness during the second pandemic period. Volunteering during the second pandemic period, before and during the second pandemic period, and during all three periods measured in the study was negatively associated with the odds of feeling lonely. Encouraging volunteering among older adults can be a useful strategy to prevent loneliness during future emergency situations like the COVID-19 outbreak.
Protective effects of Chlorella vulgaris as a feed additive on growth performance, immunity, histopathology, and disease resistance against Vibrio parahaemolyticus in the Pacific white shrimp
Authors: Eissa El-Sayed Hemdan , Aljarari Rabab Mohamed , Elfeky Amal , Abd El-Aziz Yasmin M. , Munir Mohammad Bodrul , Jastaniah Samyah D. , Alaidaroos Bothaina Ali , Shafi Manal E. , Abd El-Hamed Nadia Nazmy B. , AL-Farga Ammar , Dighiesh Hagar Sedeek , Okon Ekemini Moses , Abd El-Hack Mohamed E. , Ezzo Omaima H. , Eissa Moaheda E. H. , ElBanna Noha I. 
Published: October 2023

AbstractThe present study investigated the effect of Chlorella vulgaris on growth performance, feed consumption, body composition, and immune response of white shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus infection. Shrimps (4.00 ± 0.04 g) were divided into five groups (3 replicates/20 each) in 15 hapa (1 m3) and cultured for 56 days with five C. vulgaris experimented diets at five different concentrations (0, 15, 20, 25, and 30 g/kg feed). Growth performance, feed utilization, biomass, and body composition (protein, lipid, and ash) were analyzed and revealed significant increase (P < 0.05) in shrimp fed the high C. vulgaris diet. Additionally, the survival rate of shrimp in all experimental feeds was improved, but was not significant. Shrimp fed with C. vulgaris at different concentrations showed significantly (P < 0.05) higher antioxidant activity. The study showed that shrimp fed with a concentration of 30 g/kg C. vulgaris in the diet showed significantly (P < 0.05) highest disease resistance against the pathogen tested. Hence, dietary C. vulgaris might be used to improve growth performance, feed utilization, body composition, and immune biomarker responses, leading to disease resistance in cultured shrimp.