bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoxetine increases extracellular levels of 3‐methoxy‐4‐hydroxyphenylglycol in cultured COLO320 DM cells
Authors: Yue Chung‐Tai , Liu Yu‐Li 
Published: November 2004

AbstractFluoxetine (Prozac) is a serotonin reuptake inhibitor. It increases extracellular levels of serotonin and is used in relieving the depressive symptoms of cancer patients. It has been reported that the drug may enhance the growth of certain cancer cells. This study investigates whether fluoxetine enhances the growth of a human colon cancer cell line (COLO320 DM) and if it affects the extracellular levels of serotonin or its metabolite, 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) and other monoamines and metabolites at two cell densities. The extracellular levels of serotonin, 5‐HIAA and other monoamines and metabolites were measured simultaneously by high performance liquid chromatography from cell‐culture media after incubation of cells both with and without fluoxetine for 3 days. The viability of COLO320 DM cells was evaluated using 3‐(4,5‐cimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT). At low cell densities (1.25×105 cells ml−1), fluoxetine at 1–10 μM significantly increased the extracellular levels of serotonin (p < 0.005), 5‐HIAA (p < 0.005), and 3‐methoxy‐4‐hydroxyphenylglycol (MHPG; p < 0.001) as compared to the controls. Fluoxetine at 10–100 μM significantly inhibited the growth of COLO320 DM (p < 0.005). At high cell densities (2×106 cells ml−1), fluoxetine at 1–10 μM significantly increased the extracellular levels of MHPG (p < 0.01), and at 10 μM it significantly increased the extracellular levels of 5‐HIAA (p < 0.05). Fluoxetine at 100 μM significantly inhibited the growth of the cells (p < 0.0001). These results suggest that fluoxetine at 1 μM of effective concentration may increase the extracellular levels MHPG, in addition to serotonin and 5‐HIAA levels, yet not inhibit the growth of COLO320 DM. Copyright © 2004 John Wiley & Sons, Ltd.
Occupational hazards of interventional cardiologists: Prevalence of orthopedic health problems in contemporary practice
Authors: Goldstein James A. , Balter Stephen , Cowley Michael , Hodgson John , Klein Lloyd W. 
Published: November 2004

AbstractInvasive cardiologists generally consider radiation to be the chief occupational hazard. Heavy leaded aprons worn to reduce this risk may be associated with orthopedic complications. This study was designed to characterize the prevalence of these occupational health problems. The Interventional Committee of the Society for Cardiac Angiography and Interventions (SCAI) sent to its Internet‐registered members a Web‐based survey. Inquiries included age, years of invasive practice, and diagnostic/interventional cases/year. Questions (yes/no) focused on orthopedic (spine, hips, knees, and ankles) and radiation‐associated problems (cataracts and cancers). The survey was sent to over 1,600 members with 424 responses. Responders were on average busy and experienced, performing catheterization > 10 years in 62% of cases and > 20 years in 24% others. Average annual diagnostic‐only case load was > 200/year in 72%, > 300/year in 43%, and > 500/year in 18% of responders. Reported annual interventional caseload was > 100/year in 83%, > 200/year in 37%, and > 300/year in 15% of operators. Orthopedic problems included spine problems in 42% of responders (of these, 70% were lumbosacral and 30% cervical). Hip, knee, or ankle problems were noted in 28% of operators. Spine problems were related to the annual procedural caseload and the number of years in practice. Over one‐third reported spine problems had caused them to miss work. The results of the radiation queries were inconclusive. These results document that interventional cardiologists commonly suffer orthopedic disease, frequently leading to lost work days. Catheter Cardiovasc Interv 2004;63:407–411. © 2004 Wiley‐Liss, Inc.
Successful use of the frontrunner catheter in the treatment of in‐stent coronary chronic total occlusions
Authors: Yang Yi‐Ming , Mehran Roxana , Dangas George , Reyes Arlene , Qin Jenny , Stone Gregg W. , Leon Martin B. , Moses Jeffrey W. 
Published: November 2004

AbstractPercutaneous intervention of coronary chronic total occlusion (CTO) from in‐stent restenosis (ISR) is hindered by difficulty to cross the lesion with conventional guidewires. This study describes the successful treatment of five cases of CTOs from ISR using the Frontrunner controlled blunt microdissection catheter. Four of the five cases had failed previous attempts of percutaneous intervention with conventional guidewires. The Frontrunner catheter successfully facilitated the placement of guidewire into the distal true lumen in all five cases. The median crossing time was 10 min. No subintimal delivery of guidewire or vascular perforation was observed. TIMI 3 flow was achieved in all target vessels after further balloon angioplasty or stenting. The Frontrunner device is a safe and effective tool in the treatment of CTOs from ISR. Catheter Cardiovasc Interv 2004;63:462–468. © 2004 Wiley‐Liss, Inc.
A General Method for the Synthesis of Bastaranes and Isobastaranes: First Total Synthesis of Bastadins 5, 10, 12, 16, 20, and 21
Authors: Couladouros Elias A. , Pitsinos Emmanuel N. , Moutsos Vassilios I. , Sarakinos Georgios 
Published: November 2004

AbstractA general strategy for the synthesis of twenty naturally occurring bastadins (all but bastadin 3) is presented. A key retrosynthetic disconnection of the two amide bonds, common in all target molecules, bisects the macrocyclic core into two diaryl ether fragments, an α,ω‐diamine (western part) and an α,ω‐dicarboxylic acid (eastern part). Efficient preparation of the synthetically challenging o‐mono or dibromo‐substituted diaryl ether linkages was achieved employing the diaryl iodonium salt method. Regarding the western part, variations of the aliphatic chain were more efficiently secured by the preparation of two different α,ω‐aminonitrile moieties. Cobalt boride mediated reduction of the nitrile functionality established the required diamines and, at the same time, provided the necessary variation of the aromatic‐ring bromination pattern. Regarding the eastern part, two different dicarboxyl precursors had to be prepared in order to accommodate bromination‐pattern variations. Coupling and subsequent macrolactamization of different combinations of these key intermediates may lead at will to any member of this family of marine natural products. Four bastaranes (bastadins 5, 10, 12 and 16) and two isobastaranes (bastadins 20 and 21) were synthesized as a demonstration of the flexibility and efficiency of the approach presented.
Genetic polymorphisms in glutathione‐S‐transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma
Authors: Yang Gong , Shu Xiao‐Ou , Ruan Zhi‐Xian , Cai Qiu‐Yin , Jin Fan , Gao Yu‐Tang , Zheng Wei 
Published: November 2004

AbstractBACKGROUNDIt has been suggested that genetic polymorphisms in certain glutathione‐S‐transferase (GST) genes reduce the effectiveness of detoxifying cytotoxins generated by chemotherapeutic agents, potentially resulting in enhanced clinical responses to chemotherapy.METHODSThe authors evaluated common polymorphisms in the GSTM1, GSTT1, and GSTP1 genes for associations with overall survival in 1034 patients with invasive breast carcinoma who were recruited into the Shanghai Breast Cancer Study between 1996 and 1998, treated with chemotherapy, and followed for a median of 5.3 years.RESULTSAfter adjusting for age, tumor stage, and the use of radiotherapy and tamoxifen, women who were homozygous for the variant GSTP1 105Val allele had a 60% reduction in mortality risk compared with women who were homozygous for the Ile allele (hazard ratio, 0.4; 95% confidence interval, 0.2–0.8). No association was found with respect to any of the GSTM1 or GSTT1 genotypes.CONCLUSIONSThe results of the current study indicate a potential role for GSTP1 polymorphism in predicting the clinical outcomes of patients with breast carcinoma who are treated with chemotherapy. Cancer 2005. © 2004 American Cancer Society.
Highly Efficient Disproportionation of Dihydrogen Peroxide: Synthesis, Structure, and Catalase Activity of Manganese Complexes of the Salicylimidate Ligand
Authors: Godbole Meenal D. , Kloskowski Michael , Hage Ronald , Rompel Annette , Mills Allison M. , Spek Anthony L. , Bouwman Elisabeth 
Published: November 2004

AbstractTwo complexes, [Mn2(etsalim)4(Hetsalim)2](ClO4)2 (1), and [Mn(mesalim)2(OAc)(MeOH)]·MeOH (2), in which Hmesalim and Hetsalim are methyl and ethyl salicylimidate, respectively, have been synthesized, fully characterized by X‐ray analyses, magnetic susceptibility, UV/Vis and IR spectroscopy, and their catalase activity has been studied. Complex 1 is dinuclear and shows an Mn−Mn distance of 3.37 Å while complex 2 is mononuclear. Both complexes catalyze the disproportionation of hydrogen peroxide into water and dioxygen; they show very high catalase activity exhibiting saturation kinetics in the presence of NaOH. The rate and turnover number of the catalyzed reaction increase dramatically when a few equivalents of base (NaOH) are added to the reaction mixture. The turnover numbers for hydrogen peroxide disproportionation increase from approximately 200 to more than 1500 per manganese ion in less than 2 min for both complexes after addition of a few equivalents of NaOH. Kinetic studies of the catalyzed reaction performed on the dinuclear complex 1 in the presence of 5 equiv. of NaOH, gives kcat = 807 s−1 (± 16) and KM = 0.091 M (± 0.003). The effective catalytic efficiency is kcat/KM = 8900 M−1s−1. The kinetic parameters of the mononuclear complex 2 in the presence of 5 equiv. of NaOH, are kcat = 190 s−1 (± 4) and KM = 0.022 M (± 0.001). The effective catalytic efficiency is kcat/KM = 8600 M−1s−1. The catalase activity of the mononuclear complex, [Mn(mesalim)2Cl] (3) has also been studied, and it shows turnover numbers that are comparable to those of complex 2. ESI‐MS analyses in deuterated solvents have been used to understand the nature of the active species formed on addition of 5 equiv. of NaOH. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Studies of the Nature of the Catalytic Species in the α‐Olefin Polymerisation Processes Generated by the Reaction of Diamido(cyclopentadienyl)titanium Complexes with Aluminium Reagents as Cocatalysts
Authors: Tabernero Vanessa , Cuenca Tomás 
Published: November 2004

AbstractThe reaction of the diamido(chloro)cyclopentadienyltitanium compounds TiCpRx[1,2‐C6H4(NR′)2]Cl [CpRx = η5‐C5H5, η5‐C5(CH3)5, η5‐C5H4(SiMe3); R′ = CH2tBu, Pr] with the Grignard reagent MgClR (R = Me, CH2Ph) affords the monomethyl and monobenzyl derivatives TiCpRx[1,2‐C6H4(NR′)2]R. Upon addition of methylaluminoxane (MAO), the chloro‐ and alkyltitanium complexes show low activity towards the polymerisation of ethylene and styrene. However, no methylation was observed during the treatment of trimethylaluminium with the chloro compounds TiCpRx[1,2‐C6H4(NR′)2]Cl. Instead, these reactions give the dinuclear aluminium complexes Al2[1,2‐C6H4(NR′)2]Me4 (R′ = CH2tBu, Pr) through transmetallation of the diamido ligand, suggesting a deactivation process of the catalysts in the olefin polymerisation reactions. In an additional effort to model the catalytic species, stoichiometric reactions between the methyl derivatives TiCpRx[1,2‐C6H4(NR′)2]Me and solid methylaluminoxane (MAO) were studied by NMR spectroscopy. Monitoring of these reactions revealed the formation of zwitterionic species depending on the nature of the solvent. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
On the Scope of a Prins‐Type Cyclization of Oxonium Ions
Authors: Fráter Georg , Müller Urs , Kraft Philip 
Published: November 2004

AbstractThe Prins cyclization of an aldehyde 1 with a homoallylic alcohol 2, affording tetrahydro‐2H‐pyrans 4 via the oxonium ion 3 as central intermediate, was conceptually transferred to (alk‐3‐enyloxy)acrylates 6, which form a related oxonium ion 7 upon treatment with acids (Scheme 1). The scope and utility of this modification of the Prins‐type cyclization of oxonium ions is discussed exemplarily by means of the syntheses of ten tetrahydro‐2H‐pyran and tetrahydrofuran derivatives, featuring diverse substitution patterns as well as different degrees of molecular complexity. These target structures include (±)‐ethyl (2RS)‐2‐[(2RS,4SR,6RS)‐ and (2SR,4RS,6SR)‐2‐tetahydro‐4‐hydroxy‐6‐methylpyran‐2‐yl]propanoate (23), (±)‐ethyl [(2RS, 3RS)‐tetrahydro‐3‐isopropenylfuran‐2‐yl]acetate (32), (±)‐ethyl (2Z)‐3‐(tetrahydro‐2,2‐dimethylfuran‐3‐yl)acrylate (37), (±)‐(3aRS,6RS, 7aRS)‐octahydro‐7a‐methylbenzofuran‐6‐yl formate (42), (±)‐ethyl (2RS,3RS,4aRS,8SR,8aRS)‐hexahydro‐2,5,5,8‐tetramethyl‐7‐oxo‐2H,5H‐pyrano[4,3‐b]pyran‐3‐carboxylate (48), and (±)‐ethyl (2RS,3RS,6SR)‐tetrahydro‐6‐(2‐methoxy‐2‐oxoethyl)‐3‐methyl‐2H‐pyran‐2‐carboxylate (53) (see Schemes 3 and 5–8). Besides the stereochemistry and mechanistic details of this versatile oxonium‐ion cyclization, the synthesis of suitable starting materials is also described.
Fluorous‐Silica‐Supported Perfluoro‐Tagged Palladium Complexes Catalyze Suzuki Couplings in Water
Authors: Tzschucke Carl Christoph , Bannwarth Willi 
Published: November 2004

AbstractDifferent Pd‐complexes (see 2a–d and 3) with and without perfluoroalkyl tags were deposited on fluorous reversed‐phase silica 1 and unmodified silica gel. These supported complexes were successfully used as precatalysts for the Suzuki reaction in H2O. H2O‐Soluble aryl bromides were easily converted to the corresponding biphenyls. Although none of the complexes is H2O‐soluble, the active catalyst is most likely homogeneously dissolved. Nevertheless, the Pd‐leaching into the product was low.
Menverins A–D, New Highly Oxygenated Guaiane Lactones from Hainan Gorgonian Menella verrucosa (Brundin)
Authors: Zhang Wen , Guo Yue‐Wei , Mollo Ernesto , Cimino Guido 
Published: November 2004

AbstractFour new highly oxygenated guaiane lactones, menverins A–D (1–4), were isolated from the gorgonian Menella verrucosa (Brundin) from the South China Sea. Their structures and relative configurations were elucidated on the basis of spectroscopic data. All compounds contain a conjugated α‐methyl‐substituted α, β‐unsaturated γ‐lactone moiety, a C(8)C(9) conjugated with the γ‐lactone moiety, and an exocyclic methylene group at C(4) (trivial numbering).
A New Iterative Approach for the Synthesis of Oligo(phenyleneethynediyl) Derivatives and Its Application for the Preparation of FullereneOligo(phenyleneethynediyl) Conjugates as Active Photovoltaic Materials
Authors: Nierengarten Jean‐François , Gu Tao , Hadziioannou Georges , Tsamouras Dimitris , Krasnikov Victor 
Published: November 2004

AbstractDisymmetrically substituted oligo(phenyleneethynediyl) (OPE) derivatives were prepared from 2,5‐bis(octyloxy)‐4‐[(triisopropylsilyl)ethynyl]benzaldehyde (5) by an iterative approach using the following reaction sequence: i) Corey–Fuchs dibromoolefination, ii) treatment with an excess of lithium diisopropylamide, and iii) a metal‐catalyzed cross‐coupling reaction of the resulting terminal alkyne with 2,5‐diiodo‐1,4‐bis(octyloxy)benzene (3) (Schemes 2 and 3). Reaction of the OPE dimer 8 and trimer 13 thus obtained with N‐methylglycine and C60 in refluxing toluene gave the corresponding C60OPE conjugates 16 and 17, respectively (Scheme 4). On the other hand, treatment of the protected terminal alkynes 8 and 13 with Bu4N followed by reaction of the resulting 9 and 14 with 4‐iodo‐N,N‐dibutylaniline under Sonogashira conditions yielded 10 and 15, respectively (Schemes 2 and 3). Subsequent treatment with N‐methylglycine and C60 in refluxing toluene furnished the C60OPE derivatives 18 and 19 (Scheme 4). Compound 9 was also subjected to a Pd‐catalyzed cross‐coupling reaction with 3 to give the centrosymmetrical OPE pentamer 20 (Scheme 5). Subsequent reduction followed by reaction of the resulting diol 21 with acid 22 under esterification conditions led to bis‐malonate 23. Oxidative coupling of terminal alkyne 14 with the Hay catalyst gave bis‐aldehyde 24 (Scheme 6). Treatment with diisobutylaluminium hydride followed by dicylcohexylcarbodiimide‐mediated esterification with acid 22 gave bis‐malonate 26. Finally, treatment of bis‐malonates 23 and 26 with C60, I2, and 1,8‐diazabicylco[5.4.0]undec‐7‐ene (DBU) in toluene afforded the bis[cyclopropafullerenes] 27 and 28, respectively (Scheme 7). The C60 derivatives 16–19, 27, and 28 were tested as active materials in photovoltaic devices. Each C60OPE conjugate was sandwiched between poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate)‐covered indium tin oxide and aluminium electrodes. Interestingly, the performances of the devices prepared from the N,N‐dialkylaniline‐terminated derivatives 18 and 19 are significantly improved when compared to those obtained with 16, 17, 27, and 28, thus showing that the efficiency of the devices can be significantly improved by increasing the donor ability of the OPE moiety.
Errors in pathology and laboratory medicine: Consequences and prevention
Authors: Hollensead Sandra C. , Lockwood William B. , Elin Ronald J. 
Published: November 2004

AbstractReducing errors and improving quality are an integral part of Pathology and Laboratory Medicine. The rate of errors is reviewed for the pre‐analytical, analytical, and post‐analytical phases for a specimen. The quality systems in place in pathology today are identified and compared with benchmarks for quality. The types and frequency of errors and quality systems are reviewed for surgical pathology, cytopathology, clinical chemistry, hematology, microbiology, molecular biology, and transfusion medicine. Seven recommendations are made to reduce errors in future for Pathology and Laboratory Medicine. J. Surg. Oncol. 2004;88:161–181. © 2004 Wiley‐Liss, Inc.
Adjuvant hepatic arterial infusion after curative resection of colorectal liver metastases using removable intra‐arterial catheters with shape‐memory alloy
Authors: Tono Takeshi , Kanoh Toshiyuki , Ohnishi Tadashi , Matsushita Masaki , Nakano Yoshiaki , Kimura Yutaka , Iwazawa Takashi , Yano Hiroshi , Okamura Jun , Monden Takushi 
Published: November 2004

AbstractBackground and ObjectivesAlthough there are some reports that adjuvant hepatic arterial infusion (HAI) chemotherapy reduces the hepatic recurrence following curative resection of colorectal liver metastases, problems of indwelling catheters after chemotherapy cessation remains unsolved. The usefulness of adjuvant HAI was investigated using a removable port‐catheter system.MethodsSpiral catheters™ were attempted to be placed in 17 patients who underwent curative hepatectomy. The catheter contains a special shape‐memory alloy at its tip, which allows stable fixation to the vascular wall without coiling so the catheter can be removed if necessary. 5‐fluorouracil (5‐FU) in total dose of 12 g was intra‐arterially administered.ResultsW spiral catheters™ were successfully placed in the hepatic artery by percutaneous approach in 82% of the patients. All patients underwent scheduled chemotherapy without serious adverse events. Reservoir‐catheter system was removed easily and uneventfully after discontinuation of the chemotherapy. 3D‐CT angiography revealed that the hepatic artery was well preserved with short‐term chemotherapy. Postoperative hepatic recurrence was observed only in 18% of the patients with the median follow‐up time of 19.9 months.ConclusionsProphylactic 5‐FU HAI using W spiral catheter™ and subsequent catheter extirpation is a promising strategy following curative resection of colorectal liver metastases. J. Surg. Oncol. 2004;88:248–255. © 2004 Wiley‐Liss, Inc.
Cover Picture: Macromol. Chem. Phys. 17/2004
Authors: Vennes Melanie , Zentel Rudolf 
Published: November 2004

Cover: The picture shows optical and polarizing microscope images of textures (top) and colloidal particles (middle and bottom) of nematic and smectic liquid‐crystalline acrylate polymers. The schematic drawing shows two possible orientations of the mesogens within these colloids.Further details can be found in the Full Paper by M. Vennes and R. Zentel* on page 2303.
Cover Picture: Macromol. Mater. Eng. 11/2004
Authors: Chiovetta Mario G. , Estenoz Diana A. 
Published: November 2004

Cover: A cube‐cell mathematical model predicts the behavior of catalyst/product particles in a CSTR for ethylene polymerization under typical commercial conditions. Representation of the changing morphologies for some typical supports in high‐activity metallocenes is performed, with density and porosity evolutions calculated. For the parameters employed, to increase the catalyst activity not necessarily should produce a proportional increase in polymer yields.Further details can be found in the Full Paper by M. G. Chiovetta* and D. A. Estenoz on page 1012.
Finite Element Analysis of Eigendynamics of Rolling Tires
Authors: Brinkmeier Maik , Nackenhorst Udo 
Published: November 2004

AbstractThe eigenvalue analysis of rolling tires is one part of the simulation of tire rolling noise radiation for the reduction of traffic noise. In this paper the general strategies of numerical eigenvalue analysis for nonsymmetric matrices are shown. The special effects observed on rotating bodies are discussed in details. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On loss of stability of slow motions in stiff oscillatory systems
Authors: Gusenkova Alla , Steindl Alois , Troger Hans 
Published: November 2004

AbstractIn stiff oscillatory systems often a reduction of the order of the system is possible by splitting the motion into an essential motion on a nearby slow manifold and neglecting the fast motion. However, if the system is conservative the question of stability of the slow motion is a delicate problem. For various spring pendulum systems we, first, perform numerical simulations showing that if the stiffness of the springs is gradually reduced the slow motion looses stability. For a single spring pendulum we give an explanation of this loss of stability. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Damping Of Pedestrian‐Induced Bridge Vibrations By Tuned Liquid Column Dampers
Authors: Reiterer Michael , Hochrainer Markus 
Published: November 2004

AbstractThe excessive lateral vibrations of Londons Millenium Bridge and the Toda Park Bridge in Japan due to a large number of crossing pedestrians have raised an unexpected problem in footbridge constructions. Secondary tuned structures, like the conventional tuned mass damper (TMD) or the tuned liquid damper (TLD) were installed to the bridge in order to suppress these vibrations. In the present investigation it is proposed to apply the more efficient and more economic tuned liquid column damper (TLCD), which relies on the motion of a liquid mass in a sealed tube to counteract the external motion, while a built‐in orifice plate induces turbulent damping forces that dissipate kinetic energy. For optimal tuning of TLCDs the natural frequency and equivalent linear damping coefficient have to be chosen suitable, likewise to the conventional TMDs, as given in Den Hartog [1]. The advantages of TLCDs are: simple tuning of natural frequency and damping, low cost of design and maintenance and a simple construction. A mathematical model of a three degree‐of‐freedom (DOF) bridge coupled with an optimal tuned TLCD is derived and analyzed numerically. Furthermore, a small scale experimental model set‐up has been constructed in the laboratory of the TU‐Insitute. The experimental results are in good agreement with the theoretical predictions and indicate that TLCDs are effective damping devices for the undesired pedestrian induced footbridge vibrations. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Motion analysis of digitally controlled machines
Authors: Baksa István , Stéphán Gábor 
Published: November 2004

AbstractThe non‐linear dynamics of digital position control is investigated in the presence of Coulomb friction and round‐off errors. Periodic, transient chaotic, chaotic motions are found even in linear stable cases. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)