bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of an LC–MS/MS method for the simultaneous quantification of milbemycin oxime and praziquantel in plasma: application to a pharmacokinetic study in cats
Authors: Xie Shiting , Lu Yixing , Wang Jun , Lin Changcheng , Ye Peiyu , Liu Xiaolin , Xiong Wenguang , Zeng Zhenling , Zeng Dongping 
Published: October 2023

IntroductionMilbemycin oxime (MBO) and praziquantel (PZQ) have a broad spectrum of biological activity and are commonly used to treat the parasitic infection in the veterinary clinic. In this study, a fast and efficient LC-MS/MS method was established and validated for the simultaneous determination of MBO, PZQ, cis-4-hydroxylated-PZQ (C-4-OH-PZQ) and trans-4-hydroxylated-PZQ (T-4-OH-PZQ) and in cat plasma.MethodsExtraction of analytes and internal standards from cat plasma by acetonitrile protein precipitation, allows rapid processing of large batches of samples. MBO, PZQ, C-4-OH-PZQ, T-4-OH-PZQ, and internal standard (IS) were eluted for 13.5 min on a C18 column with a 0.1% formic acid water/acetonitrile mixture as the mobile phase.ResultsResults showed that the method had good precision, accuracy, recovery, and linearity. The linearity range was 2.5–250 ng/mL for MBO, and 10–1000 ng/mL for PZQ, C-4-OH-PZQ, and T-4-OH-PZQ. The intra-day and inter-day precision CV values of the tested components were within 15%. The extraction recoveries of the four components ranged from 98.09% to 107.46%. The analytes in plasma remained stable for 6 h at room temperature, 26 h in the autosampler (4 °C), after freeze–thaw (−20°C) cycles, and 60 days in a −20°C freezer. Method sensitivity sufficed for assessing pharmacokinetic parameters of MBO, PZQ, C-4-OH-PZQ, and T-4-OH-PZQ in plasma samples with LLOQ of 2.5 ng/mL for MBO and 10 ng/mL for PZQ, C-4-OH-PZQ, and T-4-OH-PZQ.ConclusionIn this study, a selective and sensitive LC-MS/MS method for the simultaneous quantification of MBO, PZQ, C-4-OH-PZQ, and T-4-OH-PZQ in cat plasma was developed and validated.This method had been successfully applied to evaluate the pharmacokinetics of MBO, PZQ, C-4-OH-PZQ, and T-4-OH-PZQ after a single oral administration of 8 mg MBO and 20 mg PZQ in cats.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KECEMASAN PASIEN PADA TINDAKAN PENCABUTAN GIGI
Authors: Widyastuti Tri , Khoirunnisa Nani Mira , Putri Megananda Hiranya , Ningrum Nining 
Published: October 2023

Kecemasan adalah reaksi normal manusia yang sudah tampak sejak masa anak-anak. Salah satu hal yang sering membuat anak cemas adalah pergi ke dokter gigi, terutama saat gigi harus melakukan perawatan pencabutan gigi. Bagi terapis gigi dan mulut serta dokter gigi, kecemasan terhadap perawatan gigi merupakan suatu tantangan dalam melakukan pelayanan kesehatan gigi dan mulut, khususnya pada pasien anak. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan kecemasan pasien saat pencabutan gigi di klinik utama Yayasan Kesehatan Gigi Anak Indonesia. Jenis metodologi pada penelitian ini ialah penelitian deskriptif dengan menggunakan pendekatan observasional. Jumlah sampel sebanyak 19 orang, pengambilan sampel dengan menggunakan teknik Aksidental Sampling. Peneliti mengumpulkan data secara langsung pada sampel, dengan bantuan enumerator, dan kemudian menampilkannya dalam tabel distribusi frekuensi. Hasil penelitian pada anak-anak mayoritas menunjukkan rasa cemas pada facial image scale pada wajah datar pada saat sebelum dilakukan pencabutan gigi. Wajah datar ditandai dengan perasaan agak tidak senang yang ditunjukkan dengan sudut-sudut mulut yang menunjukkan indikator ketidakpuasan sedang. Faktor yang menyebabkan kecemasan mayoritas disebabkan oleh faktor ketakutan/phobia terhadap alat perawatan gigi sebanyak 17 responden (89,5%). Faktor yang menyebabkan kecemasan terbanyak kedua ialah faktor keluarga dan teman yaitu sebanyak 10 responden (52,6%). Faktor yang menyebabkan kecemasan paling sedikit ialah faktor pengalaman traumatik yaitu sebanyak 2 responden (10,5%). Untuk mengurangi kecemasan perawatan gigi pada anak dapat menggunakan teknik tell-show-do dan penggunaan aroma terapi.
Screening of Lipid Production Capacities of Bacillus sp. Strains Isolated from Soil and Lipid Staining with Different Staining Techniques
Authors: DEMİRKAN Elif , YILDIRIM İrem 
Published: October 2023

Microbial lipids have been attracting more and more attention in recent years as promising raw
materials for the production of biodiesel and value-added compounds. In the current economic and
environmental situation, finding new renewable sources of lipids will be crucial. Recent research has
necessitated the search for new efficient microbial producers with lipid production efficiency. For this
purpose,50 Bacillus sp. strains previously isolated from the soil were screened for their lipid production
capacity. As a result of the production using a single-cell oil production medium, only two Bacillus spp.
strains showed growth. These bacteria were named as Bacillus sp. E40 and Bacillus sp. E226. Bacteria
were then characterized in terms of their biomass, lipid yields, and lipid contents. The biomass of
Bacillus sp. E40 and E226 bacterial isolates, were 0,28 and 0,22 g.L-1, respectively. The highest lipid
content was reached by E226 with 54.5%. Bacillus sp. E40 lipid content was determined as 46.4%. In
addition, both intracellular lipid staining and colony staining demonstrated the presence of lipids. With
this study, it was reported for the first time that local Bacillus sp. strains isolated from soil have lipid
producing capacity.
Sivaslı (Uşak) Yöresi Mermerlerinin Mühendislik Özelliklerinin Araştırılması
Authors: ÇELİK Haluk , ALPEREN Ayşe Nur , BAĞCI Metin 
Published: October 2023

Uşak ve çevresinde yer alan Menderes Masifinde bulunan metamorfik birimlerde Karahallı, Ulubey ve
Sivaslı ilçelerinde önemli mermer potansiyeli bulunmaktadır. Menderes Masifinde yer alan metamorfik
birimler çekirdek ve örtü birimlerden oluşmaktadır. Gnayslar çekirdek birimleri, Şist ve mermerler ise
örtü birimleri oluşturmaktadır. Masifin en yaşlı kayaçlarını oluşturan gnayslar genellikle gözlü ve bantlı
gnayslar şeklinde görülmektedirler. Şistler ise bölgede çok geniş bir alanda bulunmaktadır. Genellikle
şist ve mermerler yer yer birbirleriyle geçişli seviyeler göstermektedir. Bu çalışmada; Sivaslı İlçesinde
işletilmekte olan üç mermer ocağından alınan mermer numunelerinin fiziksel, mekanik, kimyasal,
mineralojik ve petrografik analizleri gerçekleştirilmiştir. Numunelerin fiziksel özelliklerden olan birim
hacim ağırlık değerlerinin 2.69 ile 2.80 gr/cm3 arasında olduğu, ağırlıkça su emme oranlarının %0.17
0.32 arasında değiştiği, doluluk oranı değerlerinin ise %94.04-97.63 arasında değişim gösterdiği
belirlenmiştir. Sivaslı (Uşak) mermerlerinin mekanik özelliklerden olan tek eksenli basınç dayanımı
değerlerinin 919.9-1051.1 kg/cm2 arasında, hacimce sürtünme ile aşınma dayanımı değerlerinin ise 3.90
ile 4.67 cm3/50cm2 arasında olduğu görülmüştür. Mineralojik-petrografik incelemeler neticesinde
Sivaslı mermerlerinin CaO oranlarının %50.6-53.7 arasında değişim gösterdiği numunelerin granoblastik
doku gösteren kalsit mineralleri ve daha az oranda dolomit mineralleri içerdikleri ve tane boyut
dağılımlarına göre kalsit kristallerinin 68.8 µm ile 963.1 µm arasında tane boyutlarının değiştiği tespit
edilmiştir.
Hacılar Ocağı Kireçtaşının Jeolojisi, Petrografik ve Jeokimyasal Özellikleri (Batı Toroslar, Burdur)
Authors: CENGİZ Oya , EĞİN KARACA Yeliz , KIRAY Didem 
Published: October 2023

İnceleme alanı, Batı Toroslar’da Isparta Büklümünün batı kanadı üzerinde Hacılar Köyünde (Burdur) yer
alır. Bu çalışmanın amacı, Hacılar Ocağı’ndaki Orta-Triyas-Liyas yaşlı kireçtaşının jeolojisini, mineralojik
petrografik ve jeokimyasal özelliklerini incelemektir. Kireçtaşı beyazımsı-açık-koyu gri ve bej renkli, yer
yer koyu renge sahip dolomitli seviyeler ile açık kırmızı, pembe renkli silisli kireçtaşı düzeyleri kapsar.
Genellikle masif görünümlü olan kireçtaşı Burdur fay zonu üzerinde yer aldığı için yoğun kırık ve
çatlaklara sahiptir. Hacılar bej kireçtaşı mikritik doku, yer yer sparlaşmış, oolitik yapı gösterir. Ayrıca,
kireçtaşı içerisindeki kırıkları ve erime boşluklarını dolduran kolloform ve ışınsal yapılı aragonit-kalsit,
tarak yapılı kuvars, breşik kalsit ve özşekilli dolomit kristallerine de rastlanır. Hacılar kireçtaşı petrografik
sınıflamada, vaketaşı ya da yer yer pelmikritik dokulu dolomitik kireçtaşıdır. Kireçtaşı numunelerinin
CaO ve MgO içerikleri sırasıyla % 37.36-55.74 ve % 0.43-15.45 arasındadır ve yüksek MgO değerleri
dolomit mineralinden gelir. Na2O ve K2O değerlerinin Al2O3 oranlarına ait ve MgO-CaO-Al2O3 üçlü
diyagramlara göre Hacılar kireçtaşı sedimanter kökenlidir. (Mg/Ca)-SiO2 ve Sr-(Mg/Ca) karbonat
ayırtman diyagramlarında numuneler çoğunlukla kireçtaşı, daha az dolomitik kayaç-kireçtaşı geçiş
alanında gözlenir. Bunun yanında, Ca/Mg diyagramında tüm numuneler dolomitik kayaç-kireçtaşı geçiş
zonuna düşerken, MgO/CaO ve SiO2+(Al,Fe)2O3 diyagramında çoğunlukla kireçtaşı, daha az dolomitik
kireçtaşı ve kalsitik kireçtaşı sınıfındadır. Rb-Sr-Ba üçlü ve Sr/Ba-Sr/Rb oranları diyagramları, Hacılar
kireçtaşının kıta kenarları ortamında oluştuğunu gösterir.
A Dispersive Liquid-Liquid Micro Extraction-Gas Chromatography-Mass Spectrometric Method for The Determination of 4-Nonylphenol in Water Samples
Authors: DENİZ Sabahattin 
Published: October 2023

In this study an environmentally-friendly, uncomplicated, and responsive method involving dispersive
liquid-liquid microextraction (DLLME) was presented for the isolation and analysis of 4-nonylphenol in
aquatic environments. The extraction process employed the undecanol–water dispersive liquid-liquid
system to isolate 4-nonylphenol. Essential variables impacting the efficiency of microextraction, such
as the quantities of 1-undecanol and acetonitrile, as well as the ionic strength of the aqueous solution,
were fine-tuned. Furthermore, the chromatographic parameters of the Gas Chromatography-Mass
Spectrometer (GC-MS) were optimized for precise analysis, and the analysis of 4-nonylphenol was
conducted using a linear calibration curve spanning 2-1000 µg/L, achieving a rapid 6-minute retention
time. The method exhibited a detection limit of 0.05 µg/L and a preconcentration factor of 188. Analyte
recovery rates ranged from 96% to 103%, having a relative standard deviation below 3%.The applied
procedure was effectively evaluated for its suitability in examining tap water and river water samples.
PENYULUHAN UPAYA PENCEGAHAN & PENGENDALIAN NYERI PADA PESEPEDA
Authors: Noviati Nuraini Diah , Munawarah Muthiah , Abdurrasyid Abdurrasyid , Ivanali Kesit , Happy Putra Daniel 
Published: October 2023

Sejak masa awal pandemi COVID-19 hingga saat ini, gaya hidup masyarakat mengalami perubahan dalam aspek pekerjaaa, hobi, gaya hidup, pendidikan, dan kesehatan. Olahraga menjadi aktivitas hobi yang populer selama masa pandemi. Selain untuk menjaga kesehatan dan kebugaran, manfaat berolahraga juga untuk mengurangi stress dan bersosialisasi. Ketika pandemi dan diberlakukan ‘pembatasan sosial’ area Jabodetabek, terjadi suatu fenomena, masyarakat senang dan tertarik untuk bersepeda. Penggunaan sepeda meningkat 1000 persen saat pembatasan tersebut di Jabodetabek. Namun peningkatan penggunaan sepeda tidak diimbangi oleh pemahaman mengenai faktor resiko cedera oopenyebab timbulnya nyeri muskuloskeletal yang mengakibatkan gangguan fungsi gerak. Nyeri muskuloskeletal yang tidak diharapkan ini dapat mengganggu produktifitas sehari-hari sehingga beresiko menurunkan kualitas hidup individu. Penyuluhan untuk mencegah nyeri muskuloskeletal pada pesepeda penting dilakukan agar mitra dapat menerapkan langkah-langkah dan teknik pencegahan cedera dan mengoptimalkan manfaat kebugaran bersepeda. Pengabdian ini bertujuan menyelenggarakan penyuluhan bagi para pesepeda untuk langkah-langkah pencegahan di rumah sehingga dapat mengurangi angka kejadian nyeri. Adapun mitra pengabdian adalah komunitas sepeda Purnakarya Tangerang.. Kegiatan berupa penyuluhan terhadap faktor resiko, memberikan langkah-langkah pencegahan sebelum, saat dan sesudab bersepeda dan strategi pengoptimalan tingkat kebugaran bersepeda. Luaran kegiatan adalah mitra dapat mengelola faktor resiko, langkah-langkah pencegahan, dan optimalisasi manfaat kebugaran olahraga bersepeda.
ANALYSIS OF ACID MIXTURE COMPARISON ON THE PROCESS OF DESTRUCTION OF LEAD METAL (Pb) ON SAMPLE OF CARPET SHELL’S MEAT (Ruditapes variegatus)
Authors: Latupeirissa Jola , Hattu Nikmans , S. Pada Semuel , W. Soplanit Vonny 
Published: October 2023

ABSTRACT

Analysis of the acid mixture ratio in the lead (Pb) metal deconstruction process in carpet shell’s meat samples (Ruditapes variegatus). In the deconstruction agent HNO3 : HCl (1:3), the average lead metal concentration contained in sweet clam meat is 4.6305 ± 1.066 mg/kg and for the HNO3 : H2SO4 (3:1), the average lead metal concentration contained in the same sweet clam meat was 5.6516 ± 2.556 mg/kg. Statistical test results showed no significant difference in the dissolving power of the acid mixture HNO3 : HCl (1:3) and HNO3 acid mixture: H2SO4 (3:1) as seen from the p>0.005 value, so both the HNO3 acid mixture: HCl (1:3) and HNO3 acid mixture: H2SO4 (3:1) can be used to deconstruct Pb metal in sweet clam meat (Ruditapes variegatus) because there is no significant difference in the two acid mixtures.
Markowitz Portfolio Optimization Applied On Companies Listed On The Indonesia Stock Exchange LQ-45
Authors: Sukardi Hadi Ahmad , Sari Maya , Nugraha Nugraha , Purnamasari Imas 
Published: October 2023

Optimisasi portofolio merupakan pendekatan yang sangat penting dalam pengelolaan investasi yang bertujuan untuk mencapai keseimbangan optimal antara risiko dan imbal hasil. Salah satu model optimisasi portofolio yang terkenal adalah Model Markowitz, yang dikembangkan oleh Harry Markowitz pada tahun 1952. Dalam artikel ini, kami menerapkan Model Markowitz pada perusahaan-perusahaan yang terdaftar di Bursa Efek Indonesia LQ-45, yang merupakan indeks yang mencakup 45 perusahaan terbaik di Indonesia. Tujuan dari penelitian ini adalah untuk mengidentifikasi portofolio yang optimal dengan tingkat risiko minimal atau tingkat pengembalian maksimal, berdasarkan data historis saham perusahaan-perusahaan yang terdaftar di LQ-45.

Abstract
Portfolio optimization is a very important approach in investment management that aims to achieve the optimal balance between risk and return. One of the well-known portfolio optimization models is the Markowitz Model, which was developed by Harry Markowitz in 1952. In this article, we apply the Markowitz Model to companies listed on the Indonesia Stock Exchange LQ-45, which is an index that includes 45 of the best companies in Indonesia. The objective of this study is to identify the optimal portfolio with minimal risk or maximum return, based on historical stock data of companies listed in LQ-45.
Pengaruh Iklim Organisasi dan Motivasi Kerja Terhadap Kinerja Karyawan PT Srikandi Inti Lestari Palembang
Authors: Hariansyah Kemas , Halin Hamid , Wulandari Try 
Published: October 2023

Tujuan dari Penelitian ini adalah untuk mengetahui apakah iklim organisasi dan motivasi memiliki pengaruh terhadap kinerja karyawan PT Srikandi Inti Lestari Palembang. Populasi yang digunakan di penelitian ini adalah karyawan PT Srikandi Inti Lestari Palembang sebanyak 62 orang. Penelitian ini menggunakan metode kuantitatif deskriptif dengan menggunakan uji analisis regresi linear berganda. Teknik pengumpulan data yang digunakan dalam penelitian adalah kuesioner. Teknik analisis data yang digunakan untuk menguji variable pada penelitian ini menggunakan analisis regresi linear berganda dengan menggunakan program IBM SPSS Statistics 20. Iklim Organisasi dan Motivasi memiliki pengaruh secara simultan terhadap kinerja karyawan. Namun secara parsial variable iklim organisasi tidak memiliki pengaruh terhadap kinerja karyawan, namun variabel motivasi memiliki pengaruh secara parsial terhadap kinerja karyawan.
Abstract
The purpose of this study was to determine whether organizational climate and motivation have an influence on the performance of employees of PT Srikandi Inti Lestari Palembang. The population used in this study were 62 employees of PT Srikandi Inti Lestari Palembang. This study uses descriptive quantitative methods using multiple linear regression analysis tests. The data collection technique used in the study was a questionnaire. The data analysis technique used to test the variables in this study used multiple linear regression analysis using the IBM SPSS Statistics 20 program. Organizational Climate and Motivation have a simultaneous influence on employee performance. However, partially the organizational climate variable has no influence on employee performance, but the motivation variable has a partial influence on employee performance.
Analysis of the clinical and therapeutic management of patients with eosinophilic esophagitis at the Virgen Del Rocio Hospital
Authors: Álvarez de Toledo A , Garzón Benavides M , Sousa Martín C , Pizarro Moreno A 
Published: October 2023

Resumen

La esofagitis eosinofílica (EoE) es un trastorno crónico de la mucosa esofágica que acarrea un impacto significativo en la calidad de vida de los pacientes. Dada la diversidad en la evolución clínica y la falta de homogeneidad en la aplicación de estrategias diagnósticas y terapéuticas, este estudio pretende valorar el estado actual del manejo clínico y terapéutico de esta patología en las consultas del Hospital Virgen del Rocío.

Se realizó un estudio descriptivo, con análisis retrospectivo en el que se incluyeron los pacientes diagnosticados en la unidad de Digestivo del Hospital Virgen del Rocío desde enero de 2010 hasta septiembre de 2021. Se recogieron y registraron las variables analíticas de interés y posteriormente se realizó un análisis descriptivo de las mismas, considerando estadísticamente significativo un valor de p < 0.05.

El 98,19% de los pacientes fueron diagnosticados por síntomas y el 99% de las endoscopias diagnósticas fueron sugestivas de EoE. Sólo el 26,2% de las biopsias estudiadas informaron del número de eosinófilos/campo. Los IBP fueron el tratamiento de primera línea más usado pero los corticoides tópicos obtuvieron diferencias estadísticamente significativas con respecto al resto de terapias. Hasta el 32% de los pacientes no tenían endoscopia de seguimiento.

Dada la heterogeneidad de los resultados en cuanto al diagnóstico, tratamiento y seguimiento, se confirma la necesidad de un protocolo establecido para el manejo de los pacientes con esofagitis eosinofílica del Hospital Virgen del Rocío que garantice la asistencia homogénea y ajustada a las Guías de Práctica Clínica.
Einrichtassistenzsystem für Transferpressen/Setup assistent for transfer presses
Authors: Krimm Richard , Scheu Jeremias , Hinz Lennart , Nagel Malte 
Published: October 2023

Bei mehrstufigen Umformprozessen interagieren diverse Einflüsse auf die Qualität erzeugter Werkstücke. Wiederanläufe nach Fertigungsunterbrechungen sind eine erhebliche Herausforderung. Bediener nutzten dabei implizites Wissen für erfahrungsbasierte Nachjustierungen, ohne dass die eigentliche Ursache in jedem Fall bekannt ist oder direkt behoben werden kann. Der Vorgang entzieht sich bislang der Simulation. Das hier skizzierte neue Forschungsvorhaben schafft Abhilfe.

In multi-stage forming processes, diverse impacts interact to affect the quality of generated workpieces. Therefore, relaunches after production interruptions pose considerable challenges. Operators use implicit knowledge for experience-based readjustments without knowing or being able to eliminate the cause in every case. So far, this process defies simulation. The new approach described in this paper provides a remedy.
Einordnung des Leichtbaugrades von Fügeverfahren/Classification of the degree of lightweightness of joining processes – Lightweight joining of multi-material composites
Authors: Götz Thomas , Schneider Marco 
Published: October 2023

Im Automobilbau bietet der Einsatz der Multimaterialbauweise ein signifikantes Potenzial zur Gewichtsreduktion. Zugleich erfordert diese Bauweise eine große Anzahl von Fügeverfahren für die Verbindung der unterschiedlichen Werkstoffe und Werkstoffklassen. Dabei muss eine Vielzahl an konstruktiven und materialseitigen Anforderungen berücksichtigt werden. Um in diesem Auswahlprozess den Aspekt des Leichtbaus beim Fügeverfahren selbst systematisch zu integrieren, wurde eine Methodik entwickelt, welche die Fügeverfahren im Hinblick auf ihr jeweiliges Leichtbaupotenzial bewertet.

In automotive engineering, the use of multi-material construction offers significant potential for weight reduction. At the same time, this construction method requires a large number of joining methods for connecting different materials and material classes. Also, a multitude of design and material requirements must be taken into account. To integrate the aspect of lightweight characteristic of the joining method systematically into this selection process, a methodology was developed evaluating the joining processes with regard to their respective potential for lightweight construction.
SURGICAL TACTICS FOR HEMORRHAGIC COMPLICATIONS OF PANCREONECROSIS
Authors: Boyko V. V. , Merkulov A. O. , Shevchenko O. M. , Tkach С. V. , Moiseenko A. S. , Bilodid E. O. , Kulyk I. A. 
Published: October 2023

Summary. The aim. of the study: to improve the results of surgical treatment of patients with erosive bleeding in pancreatic necrosis by using active surgical tactics with ligation of erosive arteries and semi-open methods of drainage.
The results of surgical treatment of 85 patients with erosive bleeding in pancreatic necrosis are presented. In 22 cases, erosive bleeding was recurrent, in 7 cases more than twice. There were 21 women, 64 men. The largest share of erosive bleeding was idiopathic pancreatic necrosis (35.3 %). Alcoholic and postoperative pancreatic necrosis accounted for 18.8 % and 17.6 %, respectively. A comparative analysis of surgical techniques in the treatment of erosive bleeding as a complication of pancreatic necrosis was conducted. The best results were noted in semi-open methods of drainage, where preference was given to operations aimed at identifying the source of bleeding and its filling.
Active surgical tactics with ligation of erosive arteries with the use of semi-open drainage methods in comparison with traditional tamponade interventions, allows to reduce mortality in erosive bleeding from 77 to 50 %.