bluuebunny/crossref_metadata_2025_split huggingface dataset:
INCREASING THE RELIABILITY OF AUTOMATIC SYSTEMS WHEN USING CONTROLLERS
Authors: Shutinsky O. G. , Snurnikov D. V. 
Published: December 2023

In order to evaluate the behavior of the automatic system, the understanding of the reliability of the system is established in the operational minds. In the case of operation, the system of automatic transmission can be applied to: mechanical ventilation (vibraciy, strike, post-mortem proradiance); electric navantezhen (naprugi, electric struma, push); navkolishnih umov (temperature, vologist, vise).
The inclusion of significant factors is manifested in the visual parameters of the system of nominal (developmental) values. Ci vidhilennya can be the buti nastiliki znasilnym, scho sistema staje neadtistannyj do vikoristannya, so as the vinikennnya of the great vidhilenni of the parameters of the system of development can be brought to an accident.
If the system ceases to be satisfied with the provisions of the system, the system is to be brought into view. On the basis of the analysis of the technical parameters of the system in the experimental minds, it is necessary to assess the quality of the system on the basis of the analysis of the technical parameters of the system in the experimental minds.
Thus, since it is impossible to integrate the technical parameters of the system (schematic, constructive, production and experiment) and the analysis of the system on the basis of the theory of methods and special distributions (theories of human processes and mathematical statistics).
In this way, reliability is an important problem of modern technology at the stage of infrastructure operation, and at the stage of design. The peculiarity of the automatic system is that in the case of the vidmovi obdemarcated kilkosti and the elements of the vidmov of all systems. It is possible to lead to grave problems, because the system is responsible for the implementation of important tasks, and the infrastructure is to be seen by the great war
The development of the regulatory contour is the meaning of the value of the characteristics of the contour on the basis of the characteristics of the warehouse elements.
The controller was redirected to the control circuit. In the process of developing the contours of regulation, which are stored with the quality of the elements, the work-free circuit (Рс) is vised as an additional work-free structure.
On the question of optimizing the quality of energy in city electric network
Authors: Hovorov Pylyp , Hovorov Vladlen , Kindinova Anastasiia 
Published: December 2023

As is well known, ensuring the energy quality indicators set by the State Technical Service of Ukraine in electrical networks is an extremely important task. The heterogeneity of load schedules of consumers of urban electric networks in combination with the variety of their operating modes, phase differences, non-linearity and high speed of parameter changes led to the fact that asymmetry, non-sinusoidal, voltage deviations and fluctuations in the networks became permanent factors that significantly reduce the quality of the networks and consumers connected to them. In addition, studies of the power factor in urban electrical networks indicate a low level of reactive power compensation in them. This is due to the high value of voltage and power losses in networks, the technical need and economic feasibility of compensation of reactive power in them. Research conducted at O. M. Beketov Kharkiv National University of Urban Economy, testify to the fact that the main strategic directions for improving the quality of energy in urban electric networks are voltage regulation, taking into account the comprehensive solution of the issues of improving the quality of energy and compensation of reactive power. At the same time, the technical solution to the problem is on the way of multi-level correction of quality indicators by using additional multifunctional devices, the most important place among which is occupied by devices made on the basis of thyristor-controlled voltage transformers. The paper presents the results of this study. It is also determined that in combination with the automation of the process of managing multifunctional devices, the use of multifunctional converters as a whole allows solving the issue of optimizing the operation modes of city power supply systems. The application of research results in general allows solving the issue of energy quality optimization in urban electrical networks.
ASSESSING THE LOGISTIC SYSTEM MATURITY LEVEL IN INTEGRATED SUPPLY CHAINS UNDER LOGISTIC 4.0 PARADIGM
Authors: Zhang Min , Huo Ran 
Published: December 2023

The fourth industrial revolution and digital technologies have transformed the logistics industry, leading to the emergence of Logistics 4.0 paradigm with interconnected systems, robots, big data analytics, and data-driven decision-making, which is crucial for enhancing supply chain resilience, sustainability, and customer-centricity. In this regard, the need to continuous investment in logistics system maturity assessment and development has been identified. This research article analyzes existing maturity assessment models for business systems, summarizes these models, and discusses their potential transformation under the influence of digitalization. The importance of evaluating maturity levels is highlighted through existing research but emphasizes that merely identifying maturity levels is insufficient, as improvements are necessary following the evaluation. Moreover, existing models that evaluate maturity levels need to improve accounting for industry-specific contexts and provide specific quality indicators rather than focusing on the description of maturity levels. The article aims to develop the theoretical and methodological foundations for the logistics system maturity in integrated supply chain evaluation and provide a framework for organizations to identify areas for improvement with the Logistics 4.0 paradigm. The article's hypotheses suggest that improving such factors as digital transformation, supply chain integration, organizational culture, strategic alignment, human capital, workforce development, partnerships, and collaborations can enhance the maturity level of logistic systems, leading to improved supply chain performance, but some barriers and challenges need to be overcome with the fourth industrial revolution achievements. The mutual influence of the described hypotheses highlights three key areas for evaluating logistics maturity: the level of formalization within the integration process, the maturity of individual participants, and the utilization of opportunities provided by the fourth industrial revolution. The interpretation of integrated logistic system maturity level has been given. The article provides a comprehensive interpretation of the maturity level of integrated logistics systems, which are proposed to identify based on the developed hierarchical model of fuzzy inference. Under the fuzzy model, indicators for assessing different aspects of logistic maturity have been offered, and response scenarios to maturity assessment results have been developed.
FOOD PROBLEM OF THE EASTERN REGION OF UKRAINE CAUSED BY THE WAR
Authors: Кazakova Nadiia , Neustroieva Gelena , Hromov Vadym 
Published: December 2023

The article deals with the scientifically substantiated analyses of the food problem of the eastern region of Ukraine based on its essential importance for the world problem of avoiding hunger. Taking into account the fact that the potential of external production exceeds the needs of the domestic market it is necessary to conduct a research of solving food problems when planning the development of the agricultural sector of the Ukrainian economy..
This article considers such analytical issues estimating that Ukraine has been among the top five exporters of grain and legume resources for many years. Ukraine is one of the main countries that contributes to the agricultural sector of the world economy. The activities of future specialists, when dealing with the food problem, depend on the content and nature of the knowledge that not only the coronavirus pandemic, but also armed conflicts in most of the specified countries and climate change, several years of drought contributed to problems with agricultural production in the region.
The general provisions on analysis of various options for solving this problem are given and it is estimated that the analytical approach is the most optimal, since it allows you to build a diagram for comparing percentage of the most popular agricultural crops in the sown areas. It is advisable to consider the process of selecting most of the data that have been collected before the invasion. This research paper reveals the fact that much of the concern is related to shortages in the supply of staple crops such as wheat, corn and oilseeds, which could rise up prices. The invasion also led to higher prices for fuel and related fertilizers, leading to further food shortages and higher prices. The rise in wheat prices resulting from the conflict has become a problem for the countries, heavily dependent on Russian and Ukrainian wheat exports, and raised fears of social protest.
The article analyzes economists’ views on the process of solving the food problems.It should be noted that these main issues will affect further world market prices and inflation will rise. Due to invasion, the US Department of Agriculture published a forecast for the export of grain products from Ukraine. Food and Agriculture Organization of the United Nations published information on the growth of the grain price index. Practical recommendations are provided for solving the problems.
The research has been developed to estimate that Ukraine is a leading country in the agricultural sector of the economy, which supplies food to the EU, Africa and India. Due to Russia's invasion into Ukrainian lands, many states may suffer from hunger and if the full-scale intervention into Ukraine is not stopped, then the world will face a food crisis.
Spatial Effects of Renewable and Fossil Energy Consumption on the Ecological Footprint for the EU Countries
Authors: Bucak Çağla , Önder Özlem , Catik Abdurrahman Nazif 
Published: December 2023

Abstract

This study examines the spillover of pollution among the 26 European Union (EU) countries from 1995 to 2020. In order to quantify pollution spillovers among the countries we estimated Environmental Kuznets Curve (EKC) using spatial econometric methods. Our research is unique in that it investigates ecological footprint spillovers for the EU Countries. This study also considers the direct and indirect effects of renewable and fossil energy consumption and globalization on environmental degradation in EU countries. The empirical results favor the validity of the EKC hypothesis. Our results support the presence of positive and significant ecological footprint spillovers among EU countries. Our spatial estimates also reveal the significant spillover impact of explanatory variables on the ecological footprint. The ecological footprint of the local country is declining owing to the consumption of renewable energy in neighboring countries. Furthermore, the fossil energy consumption of the local and neighboring countries has a positive impact on the ecological footprint. Evidence obtained from our spatial estimates provides useful insights to policymakers in developing appropriate environmental policies to combat climate change.
Functional Annotation and Meta-Analysis of Maize Transcriptomes Reveal Genes Involved in Biotic and Abiotic Stress
Authors: Hayford Rita K , Haley Olivia C , Cannon Ethalinda K , II John L Portwood , Gardiner Jack M , Andorf Carson M , Woodhouse Margaret R 
Published: December 2023

Abstract

Background
Environmental stress factors, such as biotic and abiotic stress, are becoming more common due to climate variability, significantly affecting global maize yield. Transcriptome profiling studies provide insights into the molecular mechanisms underlying stress response in maize, though the functions of many genes are still unknown. To enhance the functional annotation of maize-specific genes, MaizeGDB has outlined a data-driven approach with an emphasis on identifying genes and traits related to biotic and abiotic stress.
Results
We mapped high-quality RNA-Seq expression reads from 25 different publicly available datasets (17 abiotic and eight biotic studies) generated from the B73 cultivar to the recent version of the reference genome B73 (B73v5) and deduced stress-related functional annotation of maize gene models. We conducted a robust meta-analysis of the transcriptome profiles from the datasets to identify maize loci responsive to stress, identifying 3,230 differentially expressed genes (DEGs): 2,555 DEGs regulated in response to abiotic stress, 408 DEGs regulated during biotic stress, and 267 common DEGs (co-DEGs) that overlap between abiotic and biotic stress. We discovered hub genes from network analyses, and among the hub genes of the co-DEGs we identified a putative NAC domain transcription factor superfamily protein (Zm00001eb369060) IDP275, which previously responded to herbivory and drought stress. IDP275 was up-regulated in our analysis in response to eight different abiotic and four different biotic stresses. A gene set enrichment and pathway analysis of hub genes of the co-DEGs revealed hormone-mediated signaling processes and phenylpropanoid biosynthesis pathways, respectively. Using phylostratigraphic analysis, we also demonstrated how abiotic and biotic stress genes differentially evolve to adapt to changing environments.
Conclusions
These results will help facilitate the functional annotation of multiple stress response gene models and annotation in maize. Data can be accessed and downloaded at the Maize Genetics and Genomics Database (MaizeGDB).
International sanctions and climate finance in developing countries
Authors: Moteng Ghislain , Mejioguim Rose 
Published: December 2023

Abstract
Global warming has become a major concern for all countries. Understanding and identifying the factors likely to combat it is now a major challenge on the global agenda. Since the Ukraine-Russia conflict in 2014, international sanctions have attracted the attention of international organisations because of their impact on countries' well-being. However, surprisingly little is known about the link between sanctions and climate aid. This study analyses the effects of international sanctions on climate finance for a large panel of 80 developing countries over the period 2000-2019. To this end, we jointly apply the system-dynamic generalised method of moments (GMM) and the quantile regression method. The results show a negative and statistically significant relationship between international sanctions and climate finance. In other words, these restrictive measures have had an unfavourable impact on financial flows intended to support climate initiatives in developing countries. These results highlight the need to rethink economic policies and diplomatic approaches to ensure that international sanctions do not undermine efforts to promote climate finance. We also show that corruption, poverty and human capital are the mechanisms through which international sanctions influence climate finance in developing countries.
Jel Classification : F51; Q54; C32
Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling
Authors: Gama Vivian , Jones Hannah , Robertson Gabriella , O'Rourke Rebecca , Romero-Morales Alejandra , Siegenthaler Julie 
Published: December 2023

Abstract

Neural organoids derived from human induced pluripotent stem cells provide a model to study the earliest stages of neurogenesis, neural differentiation, and synaptogenesis. However, neural organoids lack supportive tissues and some non-neural cell types that are key regulators of brain development. Neural organoids have been co-cultured with non-neural structures and cell types to promote their maturation and model interactions with neuronal cells. One structure that does not form de novo with neural organoids is the meninges, a tri-layered structure that surrounds the CNS and secretes key signaling molecules required for mammalian brain development. We developed a co-culture system of neural organoids fused with fetal leptomeninges from mice with fluorescently labeled meninges. These proof-of-concept studies test the stability of the different cell types in the leptomeninges and the fused brain organoid, as well as the interface between the organoid and meningeal tissue. We test the longevity of the fusion pieces, describe best practices for preparing the meninges sample before fusion, and examine the feasibility of single or multiple meninges pieces fused to a single organoid. We discuss potential uses of the current version of the LMNO fusion model and opportunities to improve the system.
Orthoflow: phylogenomic analysis and diagnostics with one command
Authors: Turnbull Robert , Steenwyk Jacob L. , Mutch Simon J. , Scholten Pelle , Salazar Vinícius W. , Birch Joanne L. , Verbruggen Heroen 
Published: December 2023

Abstract
Species trees, which depict the evolutionary relationships among organisms, underlie many evolutionary studies. Phylogenomics, the use of genome-scale datasets for phylogenetic inference, is the current gold standard for species tree inference. The development, maintenance, and execution of phylogenomic workflows is challenging, requiring programming, data management skills, and familiarity with changing best practices. We introduce Orthoflow, a software wherein a single command automatically conducts end-to-end phylogenomic analysis—orthology inference and identification of phylogenomic markers, quality control, data matrix construction, diagnostics, and tree inference using supermatrix and supertree methods from multiple input data formats. To demonstrate the utility of Orthoflow, we successfully recapitulate the evolutionary relationships among 24 yeast species. Orthoflow increases the accessibility of researchers to conduct rigorous phylogenomic analysis flexibly. Orthoflow is freely available from PyPI (https://pypi.org/project/orthoflow/), Bioconda (https://anaconda.org/bioconda/orthoflow) and GitHub (https://github.com/rbturnbull/orthoflow) under the Apache License 2.0.
Integrated bioinformatics investigation and experimental validation reveals the clinical and biological significance of chromobox family in breast cancer
Authors: Ge Xin , Lei Shu , Wang Panliang , Wang Wenkang , Du Peng , Wang Wendong 
Published: December 2023

Abstract
Background
Chromobox (CBX) proteins are essential components of the Polycomb group and play critical roles in tumor onset, development, and metastasis. However, the prognostic significance and functions of CBXs in breast cancer (BC) progression have not been sufficiently investigated.
Methods
The expression and prognostic significance of CBX1-8 in BC were comprehensively analyzed using The Cancer Genome Atlas (TCGA) and multiple databases, including cBioPortal, Human Protein Atlas (HPA), Kaplan-Meier plotter, and TIMER. In vitro validation included conducting cell proliferation and EdU assays to confirm the oncogenic role of BC cells after CBX2 silencing. Additionally, FACS and western blotting were used to elucidate the mechanism of CBX2 in BC.
Results
The expression levels of CBX1, CBX2, CBX3, CBX4, and CBX8 were significantly elevated in BC tissues compared to normal tissues. High mRNA expression of CBX2, CBX3, and CBX5 in BC patients was significantly associated with shorter overall survival (OS). Univariate and multivariate Cox regression analysis results revealed that the mRNA expression level of CBX2 in BC patients served as an independent prognostic factor. In Luminal A and Luminal B BC subtypes, high expression of CBX2 was associated with poor prognosis. Subsequent Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed a close association between CBX2 and the cell cycle as well as DNA replication. CCK-8 and EdU assays demonstrated that silencing CBX2 inhibited the proliferation of T47D and MCF7 cell lines. Moreover, the cell cycle assay indicated that CBX2 silencing led to cell cycle arrest, accompanied by a marked reduction in the levels of CDK4 and CyclinD1. High CBX2 expression significantly correlated with the infiltration of T cells, B cells, macrophages, and dendritic cells in BC.
Conclusions
Our findings could provide new insights into identifying potential prognostic markers within the CBX family in BC. Targeting CBX2 may present a promising strategy to tackle endocrine resistance in BC therapy.
The Effect of Thyroid Hormone Level on Topographic, Densitometric and Aberrometric Values Of the Cornea
Authors: Alakuş Mehmet Fuat , Kozan Betül Dertsiz , Çağlayan Mehtap Savar , Öncül Hasan , Kılıç Jehat 
Published: December 2023

Abstract
Purpose : To investigate the topographic measurements,aberrometrics and densitometrics values ofcorneas in hypothyroid , hyperthyroid patients compared to healthy individuals.
Material and Methods: This cross-sectional comparative study included 20 hypothyroid patients(group I), 20 hyperthyroid patients (group II), and 20 age-matched controls (group III). The Pentacamhigh resolution imaging system is used to determine corneal topographic measurements,aberrometryand densitometry.
Results: Mean age group I, II and III 42.11±12.84(21-65), 44.52±10.11(20-66), 44.04±8.06(20-65)years was respectively (p =0.091). There was no significant difference between the groups nostatistically significant differences were found between the groups in terms of the 0-2 mm and 2-6 mmdensitometry values. At 6-10 mm corneal zone at all layers, including anterior, mid-stroma, posteriorand total, were significantly higher in the hyperthyroidism group compared to the control group(p=0.002, p=0.001, p=0.002 and p=0.001, respectively). At the 10-12 mm peripheral corneal zone,corneal densitometry values in all layers were significantly higher in the hyperthyroidism groupcompared to both the control group and hypothyroidism group (p<0.05 for all values). For theaberrometric measures, higher order aberrations were greater for the hyperthyroidism group than thecontrol group” (p=0.012).
Conclusion : Hyperthyroidism may affect corneal densitometric and aberometric values,which may alter the corneal transparency.
A Bibliometric and Visual Analysis of Obesity and Gastroesophageal Reflux Disease
Authors: Tan Hengbin , Luo Ping , Wang Guohui 
Published: December 2023

Abstract
Aim
To assess the research status, hotspots, and frontiers related to obesity and gastroesophageal reflux disease (GERD) using bibliometric approaches.
Material and Methods
Bibliometric analysis of the field of obesity and GERD was conducted based on database of the Web of Science Core Collection (WOSCC) from its inception to October 20, 2022. Several factors are analyzed and mapped using VOSviewer software, including the total number of publications, the number of resources and journals, countries, authors, and intellectual networks, as well as the co-citation analysis of keywords and references.
Results
A total of 2,306 papers from 480 journals with 10,010 authors from 2,628 institutes in 75 countries were included. There was an increase in publishing papers and citations each year. Most of the publications were authored by researchers from the United States and Italy. In the collaboration network map, Mayo Clinic, Karolinska Institute, the University of Washington had the largest cluster of nodes. Lagergren J, Corley DA, Whiteman DC, Vaughan TL, and Patti MG were the most prolific authors. There was a high concentration of research into bariatric surgery (BS), risk factors, body mass index (BMI), and Barrett's esophagus in this field. Future research may focus on weight gain, sleep apnea, sleeve gastrectomy (SG), and revisional bariatric surgery.
Conclusions
We summarized the research hotspots and trends, collaborative network, and future research directions in the field of obesity and GERD. In addition to help scholars understand essential information, our results will also enable them to identify research frontiers.