bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Novel Prognostic Nomogram for advanced Diffuse Large B-Cell Lymphoma
Authors: Wan Mengdi , Zhang Wei , Huang He , Fang Xiaojie , Chen Yungchang , Tian Ying , Yao Yuyi , Weng Huawei , Chen Zegeng , Yu Le , Tian Yuke , Huang Huageng , Li Xudong , Hong Huangming , Lin Tongyu 
Published: October 2023

Abstract
Background
Advanced diffuse large B-cell lymphoma (DLBCL) is a common malignant tumor with aggressive clinical features and poor prognosis. At present, there is lack of effective prognostic tool for patients with advanced (stage III/IV) DLBCL. The aim of this study is to identify prognostic indicators that affect survival and response and establish the first survival prediction nomogram for advanced DLBCL.
Methods
A total of 402 patients with advanced DLBCL were enrolled in this study. COX multivariate analysis was used to obtain independent prognostic factors. The independent prognostic factors were included in the nomogram, and the nomogram to predict the performance of the model was established by R rms package, C-index (consistency index), AUC curve and calibration curve.
Results
The training and validation cohorts included 281 and 121 patients. In the training cohort, multivariate analysis showed that Ki-67 (70% (high expression) vs ≤ 70% (low expression), p < 0.001), LDH (lactate dehydrogenase) (elevated vs normal, p = 0.05), FER (ferritin) (elevated vs normal, p < 0.001), β2-microglobulin (elevated vs normal, p < 0.001) were independent predictors and the nomogram was constructed. The nomogram showed that there was a significant difference in OS among the low-risk, intermediate-risk and high-risk groups, with 5-year survival rates of 81.6%, 44% and 6%, respectively. The C-index of the nomogram in the training group was 0.76. The internal validation of the training group showed good consistency. In the internal validation cohort of the training group, the AUC was 0.828, and similar results were obtained in the validation group, with a C-index of 0.74 and an AUC of 0.803.
Conclusion
The proposed nomogram provided a valuable individualized risk assessment of OS in advanced DLBCL patients.
CHD1L knockdown suppresses bladder cancer cell growth in vitro
Authors: Xu Feng , Shi Xiuquan , Wang Zuheng , Chen Yuhao , Xu Xiaofeng , Liu Zhe , Shi Changjie , Li Ping , Liu Youhuang , Zhang Tingling , Fu Dian , Ge Jingping , Cheng Wen 
Published: October 2023

Abstract

PurposeCHD1L is a DNA helicase protein which is involved in recombinant chromatin and DNA damage repair. As a oncogene, how CHD1L was expressed and functioned in human bladder cancer cells were still not clear. This study was conducted to investigate how CHD1L is expressed and functions in human bladder cancer cells.Materials and methodsWe detected the expression level of CHD1L in human bladder cancer 5637 cells using qPCR. Through transfecting shCHD1L-harboring lentivirus and constructing CHD1L-knockdown cell models, MTT assay and flow cytometry assay were employed to detect the changes in cell proliferation, cell cycle and cell apoptosis, respectively. Cellular ability of migration was then tested using wound-healing assay and Transwell assay.ResultsWe found that CHD1L was upregulated in bladder cancer 5637 cells. Knocking down CHD1L blocked cell cycle in G1/S transition and thus suppressed cell proliferation and cell migration, but accelerated cell apoptosis. Further exploration in the molecular mechanism indicated that dysfunctions of shCHD1L-harboring cells resulted from CHD1L downexpression may be involved in the reduction of phosphorylation levels of AKT and ERK proteins.ConclusionsThis study highlighted the tumor-promoting role of CHD1L played in bladder cancer cells, which provided a primary insight into further and deeper on related topics.
The importance of self-management for better treatment outcomes for HIV patients in a low-income setting: perspectives of HIV experts and service providers
Authors: Dadi Tegene Legese , Tegene Yadessa , Vollebregt Nienke , Medhin Girmay , Spigt Mark 
Published: October 2023

Abstract

Background
Self-management is the most important strategy to improve quality of life in patients with a chronic disease. Despite the increasing number of people living with HIV (PLWH) in low-income countries, very little research on self-management is conducted in this setting. The aim of this research is to understand the perspectives of service providers and experts on the importance of self-management for PLWH.
Methods
We used a systematizing expert interview type of qualitative methodology to gain the perspectives of experts and service providers. The study participants had experience in researching, managing, or providing HIV service in east and southern African (ESA) countries. All the interviews were audio recorded, transcribed, and translated to English. The quality of the transcripts was ensured by randomly checking the texts against the audio record. A thematic analysis approach supported by Atlas TI version 9 software.
Result
PLWH face a variety of multi-dimensional problems thematized under contextual and process dimensions. The problems identified under the contextual dimension include disease-specific, facility-related, and social environment-related. Problems with individual origin, such as ignorance, outweighing beliefs over scientific issues, low self-esteem, and a lack of social support, were mostly highlighted under the process dimensions. Those problems have a deleterious impact on self-management, treatment outcomes, and the quality of life of PLWH. Low self-management is also a result of professional-centered service delivery in healthcare facilities and health service providers' incapacity to comprehend a patient's need beyond the medical concerns. Participants in the study asserted that patients have a significant stake in enhancing treatment results and quality of life through enhancing self-management.
Conclusion and recommendation:
HIV patients face multifaceted problems beyond their medical issues. The success of medical treatment for HIV is strongly contingent upon patients' self-management practices and the supportive roles of their family, society, and health service providers. The development and integration of self-management practices into clinical care will benefit patients, their families, and the health system.
Genetic association between immune-mediated inflammatory diseases and peripheral artery disease: A Mendelian Randomization Study
Authors: Wu Haichao , Zheng Dandan , Zhou Long , Wang Qiang , Wang Tao , Liang Siyuan 
Published: October 2023

Abstract

Background:
Several observational studies have revealed that immune-mediated inflammatory diseases (IMIDs) are associated with an increased risk of peripheral artery disease (PAD). However, the causal association remains to be determined. To corroborate previous research, we conducted Mendelian randomization (MR) analysis with the aim of clarifying the associations of various IMIDs with PAD.
Methods:
two-sample MR analysis was conducted to investigate the potential causal association between six common IMIDs (including rheumatoid arthritis (RA), Crohn’s disease (CD), ulcerative colitis (UC), systemic lupus erythematosus (SLE), ankylosing spondylitis(AS), psoriasis(PSO)) and PAD. genome-wide association study (GWAS) was used to identify genetic variants associated with IMIDs and PAD. We employed the inverse variance weighted (IVW) method as the primary method to verify the causal relationship between exposures (IMIDs) and outcomes (PAD). In addition, heterogeneity test, horizontal pleiotropy test, and leave-one-out analysis were performed to evaluate the robustness of the MR results.
Results:
The IVW model yielded evidence of a positive association between RA and PAD (OR = 1.059, 95% CI: 1.026-1.094, p＜0.001), which was consistent with the results obtained from MR-Egger regression and weighted median analyses, indicating that the results of MR analysis were reliable. However, no statistically significant associations were observed between other IMIDs, including UC, CD, SLE, AS and PSO, and PAD.
Conclusion:
Our analysis supported the causal association of RA with increased risks of PAD. Strengthening screening and prevention of PAD is of great significance in reducing the risk of PAD in populations with RA.
Comparison of Preventive Effects of Combined Furosemide and Mannitol versus Single Diuretics, Furosemide or Mannitol, on Cisplatin-Induced Nephrotoxicity
Authors: Takagi Ayaka , Miyoshi Takanori , Hayashi Toshinobu , Koizumi Hinako , Tsumagari Kyouichi , Yokota Chiaki , Nakano Takafumi , Matsuo Koichi , Egawa Takashi 
Published: October 2023

Abstract

Cisplatin (CDDP)-induced nephrotoxicity is a common dose-limiting toxicity, and diuretics are often administered to prevent nephrotoxicity. However, the efficacy and optimal administration of diuretics in preventing CDDP-induced nephrotoxicity remain to be established. This study aimed to evaluate the efficacy of combining furosemide and mannitol to prevent CDDP-induced nephrotoxicity.
This study was a post-hoc analysis of pooled data from a multicenter, retrospective, observational study, including 396 patients who received one or two diuretics for CDDP-based chemotherapy, compared using propensity score matching. Multivariate logistic regression analyses were used to identify risk factors for nephrotoxicity.
There was no significant difference in the incidence of nephrotoxicity between the two groups (22.2% vs. 28.3%, P=0.416). Hypertension, CDDP dose ≥75 mg/m2, and no magnesium supplementation were identified as risk factors for nephrotoxicity, whereas the use of diuretics was not found to be a risk factor.
The combination of furosemide and mannitol showed no advantage over a single diuretic in preventing CDDP-induced nephrotoxicity. The renal function of patients receiving CDDP-based chemotherapy (≥75 mg/m2) and of those with hypertension should be carefully monitored, and magnesium supplementation is important for these patients.
RETRACTED: A moduli-selective antibody inhibits the pain receptor TRPV1 in cynomolgus monkeys without adverse temperature dysregulation
Authors: Jungholm Oscar , Trkulja Carolina , Papadia Daniela , Hägglund Jessica , Davidson Max , Stratton Jennifer , Tien Jason , Trinh Vivian , Wilson David , Quigley Anna , Sriniv Sreesha , Vazquez-Juarez Erika , Freitag Fabio , Balleza-Tapia Hugo , Marcus Monica , Frumento Paolo , Reymer Anna , Savvidi Parthenia , Willman Gabriella , Ashok Anaswara , Christakopoulou Maria-Nefeli , Bruton Joseph , Jardemark Kent , Orwar Owe 
Published: October 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Radiological Risks Associated with the Use of Some Medicinal Plants in Sinai, Egypt
Authors: Fares Soad , Fares Soad 
Published: October 2023

Abstract
This study investigated the natural radioactivity of some medicinal plants With 17 sample plants commonly used in Sinai, Egypt, and evaluated the radiological risks associated with their use. The study found that the concentration of radon in wild desert plants varied widely, with the highest concentration found in Artemisia tridentata (sagebrush). The concentration of radon in the plants was correlated with the concentration of radium in the soil, and the type of plant. The study also found a moderate correlation between radon concentration in wild desert plants and indoor radon concentration. This means that there is a positive relationship between the two variables, i.e., as the radon concentration in wild desert plants increases, the indoor radon concentration also tends to increase. This correlation is likely due to the fact that radon gas can be released from soil and rocks into the air, and wild desert plants can absorb and release radon. It is important to note that the correlation between radon concentration in wild desert plants and indoor radon concentration is not perfect, as there are other factors that can also affect indoor radon concentrations. The study found that the highest concentration of radon in wild desert plants was found in Larrea tridentata2 (sagebrush), with a concentration of 9.25 Bq/kg.
The lowest concentration of radon was found in Al-Hasak, with a concentration of 1.78 Bq/kg. The average concentration of radon in all of the wild desert plant samples was 4.45 Bq/kg. The study also found that the highest concentration of radium in wild desert plants was found in the Booklet tridentata (sagebrush), with a concentration of 190.36 Bq/kg. The lowest concentration of radium was found in Al-Hasak, with a concentration of 43.33 Bq/kg. The average concentration of radium in all of the wild desert plant samples was 0.18 Bq/kg. The study also found that the AEDEin, AEDEout, EM, Radium Concentration, EA, Radon concentration, vary depending on the type of wild desert plant. The highest AEDEin, AEDEout, EM, Radium Concentration and EA, Radon concentration. The lowest AEDEin, AEDEout, EM, Radium Concentration, EA and Radon concentration in Al-Hasak. The study provided shows that the average AEDEin and AEDEout for all of the wild desert plant samples were 64.26 µSv/y and 496.57 µSv/y, respectively. This is well below the international limits. The average Raeq for all of the wild desert plant samples was 251.78 Bq/kg, which is above the international limit. However, it is important to note that the Raeq limit is not a strict limit, and it is possible to have higher levels of Raeq in the environment without any adverse health effects. The UNSCEAR 2000 report sets the following international limits for AEDEin: 1000 µSv/y and AEDEout: 3000 µSv/y.
GH provocative tests stimulate the growth in children with idiopathic short stature
Authors: Tortora Anna , Marotta Vincenzo , Izzo Giulia , Rocco Domenico , Clemente Gennaro , Vitale Mario 
Published: October 2023

Abstract

Context: Growth hormone (GH) deficiency in a child with short stature is diagnosed by GH secretion provocative tests. When tests response is considered adequate, the short stature is considered idiopathic (ISS), and no GH replacement therapy is advised.
Objective: To determine the effect of GH provocative tests on growth rate in children with idiopathic short stature.
Design: Children with short stature with normal response to two GH provocative tests, were enrolled. Height and growth velocity were measured prior and after stimulus tests during the follow-up.
Methods Height, mid-parental height, body weight, and body mass index were measured. The height and growth rate were converted to percentiles and Standard Deviation Score (SDS) using reference ranges standardized for age and sex. GH provocative tests employed arginine or clonidine as secretagogues.
Results: Thirty-one children of both genders were enrolled. Heights were measured at test time and at a mean time prior and after the tests of 205 days and 192 days respectively. After the tests the children displayed a 3.8-fold increase in their estimated 90 days growth rate. The mean growth rate of children pre- and post-tests were -4.0 SDS and 0.3 SDS respectively (p<0.0001). Ten children with ISS were observed for about 5 months before the GH provocative tests. A small increase in growth rate was seen in only 2 of 10 children with ISS before the tests while it increased in all after the tests. The difference of the mean growth rate at first and second observation was not significant (p= 0.219).
Conclusions: Two sequential somatotropic axis provocative tests increase the growth rate in children with idiopathic short stature. The duration of this effect is to be determined.
Pre-existing PET/CT fusion images improve the diagnostic efficacy of CT-guided percutaneous lung biopsy
Authors: Ge Xiangyan , Hao Shanhu , Wang Zhiguo , Zhang Wenwen , Ding Tingting , Zhang Guoxu 
Published: October 2023

Abstract
Objective: To investigate the diagnostic efficacy and complications of CT-guided percutaneous lung biopsy based on PET/CT fusion images.
Methods: A retrospective analysis was conducted on 87 cases of percutaneous lung biopsy from January 2019 to June 2023, performed in the Department of Nuclear Medicine, Northern Theater General Hospital of the Chinese People's Liberation Army. Preoperative CT or PET-CT images of all patients indicated suspicious malignant lung nodules. Based on the imaging method, the patients were divided into the PET/CT fusion image group (47 cases) and the conventional CT group(40 cases). The PET/CT fusion image group underwent percutaneous lung biopsy guided by the fusion of PET/CT images obtained within 14 days prior to the biopsy and intraoperative CT images. The conventional CT group underwent percutaneous lung biopsy guided by intraoperative CT images.
Results: The biopsy diagnostic rate and diagnostic accuracy in the fusion image group were 68.0% (32/47) and 87.2% (41/47), respectively. In the conventional CT group, the biopsy diagnostic rate and diagnostic accuracy were 62.5% (25/40) and 67.5% (27/40), respectively. The diagnostic rate for malignant tumors in the PET/CT fusion image group (96.6%, 29/30) was significantly higher than that in the conventional CT group (86.2%, 25/29) (P=0.035). No serious procedure-related complications were observed in the PET/CT fusion image group or the conventional CT group.
Conclusion: PET/CT fusion images have important clinical value in improving the biopsy diagnostic rate, diagnostic accuracy, and reducing procedure-related complications for suspicious lung nodules.
Predictive Value of IL-6+SOFA for Mortality Risk in Critical Ill Patients
Authors: Wu Liyan , Zhang Ye , Wang Junyu , Wei Bing , Liu Yugeng 
Published: October 2023

Abstract
Objective
Mortality after critical illness is greatly related to a prediction of disease and clinical decision. We aimed to assess the prognostic value of Interleukin-6 (IL-6) for critically ill patients.
Methods
199 patients with critically ill were included from the emergency department of Beijing Chaoyang Hospital, Capital Medical University from October 2020 to April 2021. IL-6 and other markers were tested immediately after admission. Score Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) related to critical illness were calculated. The correlation of monitoring markers and clinical 28-day mortality was analyzed by logistic regression, and the receiver operating characteristic curve (ROC).
Results
Among the 199 patients, 139 are dead and 60 are survival within 28 days, respectively. SOFA, APACHE II, systolic blood pressure (SBP), serum calcium, Albumin (ALB), high density lipoprotein (HDL), and IL-6 were significantly different in the non-survival and survival groups (P< 0.05). Logistic regression analysis showed that IL-6, SOFA, APACHE II, and SBP were independent predictors for 28-day mortality in critically ill patients (P< 0.05). The area under curve (AUC) of ROC curve in IL-6 was 0.736 (sensitivity 77%, specificity 66.7%, and cut-off 24.41), which was lower than AUC of ROC curve in SOFA (AUC 0.859, sensitivity 82%, specificity 78.3%, and cut-off 5.5) and APACHE II (AUC 0.767, sensitivity 57.6%, specificity 90%, and cut-off 20.5). The combined evaluation of IL-6+ SOFA had better diagnostic values than IL-6 (Z= 3.799, P= 0.000) or SOFA (Z= 2.283, P= 0.022).
Conclusions
IL-6, SOFA and APACHE II are associated with the prognosis of critically ill patients. Compared with the above markers alone, the IL-6+SOFA score has better predictive value.
Uranium and Radium-226 in Drinking Water of Some Regions of Ukraine: 25 Year of Research and Assesment of Hypothetical Irradiation Doses
Authors: Buzynnyi Mykhailo , Mykhailova Liubov 
Published: October 2023

Abstract
The article summarizes the activity concentrations data of 226Ra and the sum of uranium isotopes (∑U) in samples of drinking underground water for different regions of Ukraine studied during 1998–2023 in the radiation monitoring laboratory of the State Institution "O.M. Marzieiev Institute of Public Health National Academy of Medical Sciences of Ukraine. Arithmetic mean and standard deviations, minimum and maximum values for 226Ra and ∑U activity concentrations are presented for the entire 1240 sample set and for each region separately. Collected data show that the established state permissible level for drinking water of 1.0 Bq/l is exceeded for 226Ra in 1.1% of the studied samples, and for ∑U - in 3.9% correspondingly. The detected high levels of 226Ra and ∑U activity concentrations correspond to certain regions belonging to the Ukrainian crystalline shield territory. A comparison of the current data with the data of previous studies held during of 1989–1991 [1] indicates a significant difference: for the previous studies the average and standard deviations are much higher. We attribute this to the fact that the centralized sampling of previous studies was random, and it was related exclusively to communal water supply systems. At the same time, the current sample set covers a much larger number of regions, different water consumers; the data set includes the results of repeated studies for a large number of sources, in particular, sources with purified water. Hypothetical exposure doses caused by consumption of 226Ra and ∑U in water for the current sample set were estimated for different age groups for each sample studied, as is, without taking into account the pattern of water consumption. The corresponding dose exceeds the WHO recommended value of 0.1 mSv per year for children under the age of one year for 220 cases (17.7%). This dose limit excess for other age groups corresponds - for children: aged 12–17 years – 13.1%, aged 1–2 years − 7.4%, 7–12 years old − 5.6%, 2–7 years old − 3.9% and for adults − 4.1%.
New paint formulation based on vegetable oil-based polymers containing Cu (II), and Co (II), and study their uses as antimicrobial and anticorrosive binders for coating applications
Authors: Hamza S. F. , Elsawy M. M. , abdel-salam Fatma , Sharaf Mohamed H. , El-Wahab H. Abd 
Published: October 2023

Abstract
Linoleic Fatty Acid based poly(ester amide) containing Copper and Cobalt as anticorrosive and antimicrobial binders for protective paints were prepared. The prepared polyesteramide resins were confirmed spectroscopically and investigated by thermogravimetric analysis, Energy Dispersive X-ray and Scanning Electron Microscopy studies. Different substrates either glass or mild steel strips were coated by using the prepared binders with a thickness of 120 +/- 5 µm using a brush. Using international testing standards, the physico-mechanical properties and chemical resistance of the resins were tested to evaluate their coating performance. The obtained results of mechanical properties of the dry coated films hass been enhanced such as Scratch Hardness, and cross-cutt adhesion however the Alkali resistance of the dry coated films has been also improved fron < 15 dys to be > 30 days and Acid resistance the resistance also, incresed from 20 to > 30 days .Furthermore, the resins were assessed as anti-corrosive and antibacterial single coatings by combining them with primer compositions. The results illustrated that Copper and Cobalt-incorporated linoleic fatty acids, within the resin structure, enhanced the antibacterial activity and has been affected on the primer coating formulation which improved their biological activity comparing with sample blank. The observed results of corrosion resistance for the painted steel films based on Copper and Cobalt-incorporated linoleic fatty acids, such as degree of rusting, blistering, and scribe failure confirmed that the prepared resins can be using as anticorrosive binder for steel protection.