bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Synthesis of Silica- Polysaccharides Nano- composites from Sodium Silicate and Aloe Vera gel for Self-cleaning of Solar Mirrors
Authors: Badr Moshiera A. A. , Khalil Ahmed Asaad Ibrahim , Khalil Mostafa M. H. , Hafez Ashraf , Mostafa Eman M. 
Published: January 2024

Abstract

Synthesis of silica-Nano-composites from both sodium silicate and Aloe Vera gel via low-cost sol-gel silica nanoparticles (Si NPs) was investigated to be used as self-cleaning for solar mirrors. The produced materials were analyzed by (EDX) which indicates the existence of a high content of silicon in the Nano-silica composites. FTIR was utilized to obtain the structure characterization of our samples, whereas the poly-siloxane groups already formed and found the backbone of Si-O-Si. X-ray diffraction (XRD) was also utilized to identify the silica structure, whereas a broad peak and an amorphous phase were obviously created. The images of Nano-silica content embedded in polymer with different magnifications were obtained using (SEM). The surface roughness of the Nano-silica composites was attained using the Atomic Force microscope (AFM). The hydrophobicity of the solar mirrors surface was investigated using the contact angle measurement and zeta potential measurement. The results obtained by both Thermo-gravimetric analysis and data thermal analysis (TGA & DTA) illustrated that the Nano-silica composite with 40 ml of Aloe Vera gel is more stable than that obtained of Nano silica composites with 20 ml and 60 ml of Aloe Vera gel. The reflectance of solar mirrors after using Nano-silica composite assures high efficiency.
A novel solution for seepage problems using physics-informed neural networks
Authors: Luo Tianfu , Feng Yelin , Huang Qingfu , Zhang Zongliang , Yan Mingjiao , Yang Zaihong , Zheng Dawei , Yang Yang 
Published: January 2024

Abstract
A Physics-Informed Neural Network (PINN) provides a distinct advantage by synergizing neural networks' capabilities with the problem's governing physical laws. In this study, we introduce an innovative approach for solving seepage problems by utilizing the PINN, harnessing the capabilities of Deep Neural Networks (DNNs) to approximate hydraulic head distributions in seepage analysis. To effectively train the PINN model, we introduce a comprehensive loss function comprising three components: one for evaluating differential operators, another for assessing boundary conditions, and a third for appraising initial conditions. The validation of the PINN involves solving four benchmark seepage problems. The results unequivocally demonstrate the exceptional accuracy of the PINN in solving seepage problems, surpassing the accuracy of FEM in addressing both steady-state and free-surface seepage problems. Hence, the presented approach highlights the robustness of the PINN and underscores its precision in effectively addressing a spectrum of seepage challenges. This amalgamation enables the derivation of accurate solutions, overcoming limitations inherent in conventional methods such as mesh generation and adaptability to complex geometries.
Irregularity in sleep-wake rhythm affects CPAP adherence
Authors: Honma Aya , Nohara Marina , Honma Sato , Homma Akihiro 
Published: January 2024

Abstract
This study aims to evaluate the impact of sleep-wake rhythm regularity on continuous positive airway pressure (CPAP) adherence. We retrospectively analyzed sleep-wake rhythms with activity monitoring and CPAP adherence among obstructive sleep apnea (OSA) patients newly diagnosed and introduced to CPAP therapy at the Sapporo Hanazono Hospital from January 2018 to June 2022. Among a total of 45 patients, 10 withdrew from CPAP therapy within a year. Nineteen were classified into the good-adherence and 16 into the poor-adherence group. No significant differences were detected among the groups in apnea hypopnea index (AHI), sleep efficiency, or subjective sleep quality, but a difference was observed in sleep latency, with CPAP withdrawal group showing higher variability in sleep onset and lower regularity and/or amplitude in circadian behavior activity rhythm than the good-adherence group. Our results suggest that irregularities, particularly in sleep onset, and damped sleep-wake rhythm can be risk factors for CPAP withdrawal.
Sexual Negotiation and Power Imbalance Influencing Intimate Partner Violence Among Adolescent Girls and Young Women in Nigerian Urban Slums
Authors: Ikuteyijo Olutoyin Opeyemi , Akinyemi Akanni Ibukun , Ikuteyijo Lanre Olusegun , Owolodun Babatunde Samuel , Merten Sonja 
Published: January 2024

Abstract
This study looks at the complexity of sexual negotiation in the context of gender inequality and power inequalities in patriarchal societies, using Nigeria as an example. It emphasizes the necessity of knowing the risks and problems that adolescent girls and young women (AGYW) confront in these contexts, including their vulnerability to intimate partner abuse. The study dives into issues surrounding the negotiation of safe sex among AGYW and its impact on the possibility of intimate partner abuse using an anthropological approach and qualitative methodologies such as in-depth interviews and focus group discussions. Some of the most important things that were found were the environmental factors that make the power dynamics between AGYW and their partners unequal, the prevalence of androcentric bias in sexual decision-making and family planning, and how these power struggles lead to gender-based violence, such as physical harm and injury. The study recommends assisting young people in developing a culture of respect in sexual relationships and negotiations, which aligns with Nigeria's Sustainable Development Goal (SDG) 5.6.1 and is critical for promoting equality and protecting the well-being of AGYW.
Coexistence of low-grade component predicts better prognosis in patients with primary, solitary high-grade non-muscle invasive bladder cancer
Authors: Ji Jiaxiang , Wang Fei , Lai Chin-Hui , Xu Tao , Hu Hao 
Published: January 2024

Abstract
Background
To determine the impact of coexisted low-grade components on the prognosis of high-grade non-muscle-invasive bladder cancer (NMIBC).
Method
A total of 167 patients with a mean follow-up of 39.32 months underwent transurethral resection of primary, solitary non-muscle invasive bladder tumor between January 2010 and December 2019, including 35 patients with coexisted low-grade components and 132 patients with pure high-grade tumors. All patients underwent adequate intravesical chemotherapy.
Result
Baseline characteristics were well balanced between patients with pure high-grade tumor and those with coexisted low-grade components. Five-year recurrence-free survival was much worse for pure high-grade tumor compared to high-grade tumor with coexisted low-grade component (50.5% vs 80.0%, p = 0.01). Multivariable cox regression analysis revealed coexisted low-grade components to be an independent risk factor for recurrence (hazard ratio = 2.34, p = 0.02). Other significant contributing factor was T1 stage (hazard ratio = 2.09, p = 0.01).
Conclusion
Coexistence of low-grade component predicts better prognosis in patients with primary, solitary high-grade non-muscle invasive bladder cancer.
An Alternative Therapeutic Approach For Hyperemesis Gravidarum That is Unresponsive to Conventional Treatment: Mirtazapine
Authors: Aktemur Gizem , Çakır Betül Tokgöz , Sucu Serap Topkara , karabay Gülşan , Bucak Mevlüt , Ulusoy Can Ozan , Şeyhanlı Zeynep , Tonyalı Nazan Vanlı , İskender Can Tekin 
Published: January 2024

Abstract
Objective: To evaluate the efficacy of mirtazapine using the PUQE score in the treatment of resistant hyperemesis in pregnant women diagnosed with hyperemesis gravidarum who did not respond to standard treatment protocols. Conventional treatments often fall short in providing relief for a subset of patients, necessitating exploration of alternative therapeutic approaches.
Methods; A total of 100 pregnant women, comprising 50 treated with mirtazapine (Group 2) and 50 receiving conventional antiemetics (Group 1), were analyzed. Results demonstrated a notable reduction in Pregnancy-Unique Quantification of Emesis (PUQE) scores in the mirtazapine group compared to the conventional treatment group.
Results; The PUQE score, which was first evaluated before the medication, was higher in the HG with mirtazapine group (p = 0.003). Compared to the HG with other drugs group, the PUQE score on post-drug day 1 was lower in the HG with mirtazapine group (p = 0.001, respectively). Compared to HG with other drugs group, PUQE score was lower in HG with the mirtazapine group on post-drug day 3 (p =0.001, respectively). Compared to the HG with other drugs group, the PUQE score on the 7th post-drug day was lower in the HG with mirtazapine group (p =0.001, respectively).
Conclusion; This study showed that mirtazapine was effective in cases of hyperemesis gravidarum that did not respond to increasing treatment. Randomized, controlled, prospective trials are necessary to ascertain the safety of the medicine and investigate the enduring consequences of mirtazapine consumption. What does this study add to the clinical work Mirtazapine can be regarded as a reliable and efficient intervention for mitigating adverse maternal and perinatal consequences in patients experiencing intractable nausea and vomiting. This therapy option is particularly suitable for individuals who have not responded to alternative therapies, have severely restricted oral intake, and have experienced substantial weight loss.
Clinical and Radiographic Evaluation of Gelatin/Beta-Tricalcium Phosphate Sponges with or without Concentrated Growth Factor in the treatment of Localized Class II Gingival Recession defects
Authors: saeed safinaz saleh mohamed , darwish samia , saudi hussein , elshamy eman , Shoukeeba malak 
Published: January 2024

Abstract
Background: The aim of this study was to compare, clinically and radiographically, the effectiveness of gelatin sponges loaded with β-tricalcium phosphate with or without concentrated growth factor (Groups I & III) versus collagen with concentrated growth factor (Group II) in the treatment of Miller class II gingival recession.
Materials and Methods: Twenty-one sites in 11 patients with Miller class II gingival recession were included in the present study. Sites were allocated randomly to be treated with gelatin sponges loaded with β-tricalcium phosphate with or without concentrated growth factor and collagen with concentrated growth factor. At baseline and, 3, 6 and 12 months after surgery, the following clinical parameters were recorded: recession depth, recession width, pocket depth, clinical attachment level,height of keratinized gingiva, gingival thickness, percentage of root coverage, and digital measurement.
Results: All groups showed significant improvement in all clinical parameters and labial bone gain was observed after 12 months compared to baseline measures. Groups II & III showed a statistically significant improvement when compared with Group I, while radiographically the differences in the amount of labial bone gain and volume between groups were not statistically significant at any study period post-treatment. However, there was more bone gain in group III than group II and both groups showed better results than group I.
Conclusion: The results of the present study indicated that, gelatin sponges loaded with β-tricalcium phosphate with or without concentrated growth factor (Groups I & III) and collagen with concentrated growth factor (Group II), all led to favorable clinical, and radiographic outcomes. While collagen with concentrated growth factor showed superior clinical results and gelatin sponges loaded with β-tricalcium phosphate with concentrated growth showed superior radiographic results compared to gelatin sponges loaded with β-tricalcium phosphate alone, it was therefore postulated that, the addition of concentrated growth factor may have been a potentiating material, which could have enhanced periodontal tissue repair.
An analytical study of the body postural characteristics of young elite alpine skiers and the correlation between their body postural characteristics and specialized strength
Authors: Guo Ao , Wang Yufeng , Sun Xiaolei , Liu Xuyang , Yue Jing 
Published: January 2024

Abstract
The purpose of this study was to analyze the body postural characteristics of young elite alpine skiers and to investigate whether the athletes' body postures were the results of specific training exercises. Moreover, the body postural characteristics of the athletes and their OPTOJUMP test scores were analyzed to determine whether their body postural characteristics and specific strength were correlated with the aim of determining whether their body postural characteristics can be used as important reference indices for the selection and training of other alpine ski athletes. The large number of common abnormal postural problems and specific abnormal postural conditions detected in this study suggest that young elite alpine skiers have core muscle strength deficiencies and muscle strength imbalances, which will have an impact on athletic performance. Genu valgum may be the most influential factor that has the greatest impact on specialized strength and injury risk in athletes. Therefore, the body postural assessment test is not only a scientific guide used to modify the training program for young elite but could also be a reference guide for athlete selection and training.
Nutritional ecology of a prototypical generalist predator, the red fox (Vulpes vulpes)
Authors: Balestrieri Alessandro , Gigliotti Sofia , Caniglia Romolo , Velli Edoardo , Zambuto Francesco , De Giorgi Erika , Mucci Nadia , Tremolada Paolo , Gazzola Andrea 
Published: January 2024

Abstract
Generalist species, which exploit a wide range of food resources, are expected to be able to combine available resources as to attain their specific macronutrient balance (intake target). Among mammalian predators, the red fox Vulpes vulpes is a widespread, opportunistic forager: its diet has been largely studied, outlining wide variation according to geographic and climatic factors. We aimed to check if, throughout the species’ European range, diets vary widely in macronutrient composition or foxes can combine complementary foods to gain the same nutrient intake. First, we assessed fox’s intake target in the framework of nutritional geometry. Secondly, we tried to highlight the effects of unbalanced diets on fox density, which was assumed as a proxy for Darwinian fitness, as assessed in five areas of the western Italian Alps. Unexpectedly, the target macronutrient ratio of the fox (52.4% protein-, 38.7% lipid- and 8.9% carbohydrate energy) was consistent with that of hypercarnivores, such as wolves and felids, except for carbohydrate intakes in urban and rural habitats. The inverse relation between density and the deviation of observed macronutrient ratios from the intake target suggests that fox capability of surviving in a wide range of habitats may not be exempt from fitness costs and that nutrient availability should be regarded among the biotic factors affecting animal abundance and distribution.
Silencing Of The DNA Damage Repair Regulator PPP1R15A Sensitizes Acute Myeloid Leukemia Cells To Chemotherapy
Authors: Bouchla Anthi , Sotiropoulou Christina D. , Esteb Christopher , Loupis Theodoros , Papageorgiou Sotirios G. , Delikonstantinos Georgia G. , Pagoni Maria , Hatzimichael Eleftheria , Delatola Maria , Kalomoiri Smaragdi , Apostolidou Elisavet , Kontos Christos K. , Thomopoulos Thomas P. , Karantanos Theodoros , Pappa Vasiliki 
Published: January 2024

Abstract

Acute Myeloid Leukemia (AML) is a life-threatening disease whose induction treatment consists of combination chemotherapy with Idarubicin and Cytarabine for fit patients. Treatment failures are frequent, urging the need for novel treatments for this disease. The DNA Damage Response Mechanism (DDR) comprises numerous molecules and pathways intended to arrest the cell cycle until DNA damage is repaired or else drive the cell to apoptosis. AML-derived cell lines after treatment with Idarubicin and Cytarabine were used for studying the expression profile of 84 DDR genes, through PCR arrays. Utilizing de novo AML patient and control samples we studied the expression of PPP1R15A, CDKN1A, GADD45A, GADD45G, and EXO1. Next, we performed PPP1R15A silencing in AML cell lines in two separate experiments using siRNA and CRISPR-cas9, respectively. Our findings highlight that DDR regulators demonstrate increased expression in patients with high cytogenetic risk possibly reflecting increased genotoxic stress. Especially, PPP1R15A is mainly involved in the recovery of the cells from stress and it was the only DDR gene upregulated in AML patients. The PPP1R15A silencing resulted in decreased viability of Idarubicin and Cytarabine-treated cell lines, in contrast to untreated cells. These findings shed light on new strategies to enhance chemotherapy efficacy and demonstrate that PPP1R15A is an important DDR regulator in AML and its downregulation might be a safe and effective way to increase sensitivity to chemotherapy in this disease.
Impact of simulated in vitro gastrointestinal digestion on the antioxidant activity and phenolic compounds of soursop peel (Annona muricata L.).
Authors: Domingues Yasmin Ourives , Lemes Geriel Araújo , de Oliveira Fellipe Lopes , de Souza Thamara Rosa , Silva Bibiana , Morzelle Maressa Caldeira 
Published: January 2024

Abstract
This work aimed to investigate in vitro phenolics bioaccessibility and soursop peel's antioxidant activity. Proximate composition, ascorbic acid, total phenolic compounds, and in vitro antioxidant activity (DPPH, ABTS, and FRAP assays) were conducted on soursop peel and pulp. The accessibility of total phenolics and antioxidant capacity of soursop peel and pulp was assessed through simulated in vitro digestion. Soursop peel had a significant amount of fiber, particularly insoluble fiber, and higher levels of total phenolic compounds and antioxidant capacity than pulp. The pulp has 30% higher levels of ascorbic acid than the peel. Simulated in vitro digestion, the total phenolic compounds of the peel exhibited stability throughout the gastric and intestinal stages. In the pulp, there was an increase in total phenolic compounds that persisted until the final stage. After the simulation of in vitro digestion, the peel showed stability in DPPH antioxidant capacity analysis and obtained higher accessibility in the enteric II stages (40% and 29%) on ABTS and FRAP assays. Soursop pulp increased accessibility in the gastric stage on DPPH and FRAP assay. In the ABTS method of antioxidant capacity evaluation, the pulp showed the highest values in enteric phase II. These results are essential for human nutrition as they provide information about soursop peel and pulp's nutritional and bioactive composition. Furthermore, the in vitro accessibility of these compounds offers insights into their potential utilization by the organism. This knowledge holds significant implications for nutrition experts, as it can inform the development of healthier dietary habits and promote enhanced health outcomes.
Carbon Nanotube-Encapsulated Cobalt for High-Efficiency Zinc-Air Flow Battery: Integration of Single Atom Catalysis and Space Confinement
Authors: Zhao Jing , Liu Mufei , Dong Jinqiao , Dong Hongxing , Wang Guiling 
Published: January 2024

Abstract
To meet the practical demand of zinc-air battery cathode noble metal catalyst substitutes are required. Herein, we integrating non-precious single-atom catalysis and space confinement present an effective approach for the large-scale, in-situ growth of CoN3-doped carbon nanotubes (CNTs) coated with Co nanoparticles (Co@CoN3/CNTs), without adding additional additives. The in-situ grown CNTs serves a dual purpose by acting as a matrix for dispersed atomic CoN3 sites and providing a space confinement effect on Co nanoparticles, resulting in lower energy barriers and superior mass transport capability. Furthermore, Co3C species derived from the Co-based zeolitic imidazolate frameworks (Co-ZIFs) act as catalysts for the direct arrangement of surrounding C-N groups. The resulting Co@CoN3/CNTs-800 displays remarkable oxygen reduction reaction (ORR) performance, with a half-wave potential of 0.84 V surpassing that of Pt/C counterparts. Moreover, the rechargeable zinc-air flow battery exhibits a peak power density of 169.5 mW cm-2 and superior recyclability.
Biological properties of Adipose-derived stem cells (ADSCs) and Bone marrow stem cells (BMSCs)
Authors: Cao Yan , Li Wei , Cao Yang , Liu Yingping 
Published: January 2024

Abstract
Background
Osseointegration is also a clinal problem especially in patients with systemic diseases. Mesenchymal stem cells provide a new technology to solve this problem. Among them, ADSCs and BMSCs are the most utilized. But which one is better remains a mystery.
Results
In our research, cell sheet of ADSCs and BMSCs all could enhance the osseointegration. BMSCs improved the osteogenesis rather than ADSCs. while ADSCs improve the proliferation and migration than BMSCs. They all could improve the gene expression of osteogenesis and BMSCs do it better.
Conclusions
ADSCs and BMSCs all can improve the osseointegration and could be a therapeutic method in implantology.
Cerebellar compensation: a case of aphasia due to cerebellar hemorrhage
Authors: Kinoshita Yukiko , Hatakeyama Masahiro , Otsuki Mika , Ishiguro Takanobu , Saji Etsuji , Kanazawa Masato , Onodera Osamu 
Published: January 2024

Abstract

Background
Recently, patients with cognitive dysfunction due to cerebellar lesions (cerebellar cognitive affective syndrome [CCAS]) have been reported. Language impairments in CCAS are generally subtle; however, we encountered a patient who developed severe aphasia due to cerebellar hemorrhage.
Case Report:
A 77-year-old right-handed woman with heart failure was admitted to a nearby hospital. During hospitalization, she had a cerebral infarction of the left inferior parietal lobule and developed aphasia, characterized by phonemic paraphasia with repeated self-corrections and word-finding difficulty. After discharge, her symptoms gradually improved and she had no difficulty in her daily life. One year after the onset of cerebral infarction, the patient was admitted to our hospital with cerebellar ataxia and aphasia. Her aphasia symptoms were characterized by phonemic paraphasia with repeated self-corrections and word-finding difficulties, consistent with the symptoms that she developed on initial admission, as well as word comprehension deficits. Computed tomography revealed a hemorrhage in the right cerebellar hemisphere. Magnetic resonance imaging of the brain revealed no recent infarctions.
Discussion
Phonemic paraphasia with repeated self-correction is a characteristic symptom of left inferior parietal lobule lesions and has not been reported in patients with isolated cerebellar lesions. Thus, it is thought that the right cerebellar hemisphere compensated for the function of the left inferior parietal lobule after cerebral infarction and that functional compensation was disrupted due to a hemorrhage. This case report suggests that the underlying mechanisms of functional recovery from aphasia depend on the interplay between the cerebrum and the cerebellum.
RETRACTED: LncRNA HOXD-AS1/ miR-182-5p / FOXO1 axis regulates invasion and migration of neuroblastoma cells
Authors: Wang Xiao-Hui , Zhang Shu-Feng , Wu Hai-Ying , Yin Yao , Gao Jian , Wang Lin , Wang Xu-Hui , Gao Tian-Hui 
Published: January 2024

Abstract
The authors have requested that this preprint be removed from Research Square.