bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortico-cortical stimulation and robot-assisted therapy (CCS and RAT) for upper limb recovery after stroke: study protocol for a randomised controlled trial
Authors: Cinnera Alex Martino , Bonnì Sonia , D’Acunto Alessia , Maiella Michele , Ferraresi Matteo , Casula Elias Paolo , Pezzopane Valentina , Tramontano Marco , Iosa Marco , Paolucci Stefano , Morone Giovanni , Vannozzi Giuseppe , Koch Giacomo 
Published: December 2023

Abstract
Background
Since birth, during the exploration of the environment to interact with objects, we exploit both the motor and sensory components of the upper limb (UL). This ability to integrate sensory and motor information is often compromised following a stroke. However, to date, rehabilitation protocols are focused primarily on recovery of motor function through physical therapies. Therefore, we have planned a clinical trial to investigate the effect on functionality of UL after a sensorimotor transcranial stimulation (real vs sham) in add-on to robot-assisted therapy in the stroke population.

Methods
A randomised double-blind controlled trial design involving 32 patients with a single chronic stroke (onset > 180 days) was planned. Each patient will undergo 15 consecutive sessions (5 days for 3 weeks) of paired associative stimulation (PAS) coupled with UL robot-assisted therapy. PAS stimulation will be administered using a bifocal transcranial magnetic stimulator (TMS) on the posterior-parietal cortex and the primary motor area (real or sham) of the lesioned hemisphere. Clinical, kinematics and neurophysiological changes will be evaluated at the end of protocol and at 1-month follow-up and compared with baseline. The Fugl-Meyer assessment scale will be the primary outcome. Secondly, kinematic variables will be recorded during the box-and-block test and reaching tasks using video analysis and inertial sensors. Single pulse TMS and electroencephalography will be used to investigate the changes in local cortical reactivity and in the interconnected areas.

Discussion
The presented trial shall evaluate with a multimodal approach the effects of sensorimotor network stimulation applied before a robot-assisted therapy training on functional recovery of the upper extremity after stroke. The combination of neuromodulation and robot-assisted therapy can promote an increase of cortical plasticity of sensorimotor areas followed by a clinical benefit in the motor function of the upper limb.

Trial registration
ClinicalTrials.gov NCT05478434. Registered on 28 Jul 2022.
In-silico guided chemical exploration of KDM4A fragments hits
Authors: Lombino Jessica , Vallone Rosario , Cimino Maura , Gulotta Maria Rita , De Simone Giada , Morando Maria Agnese , Sabbatella Raffaele , Di Martino Simona , Fogazza Mario , Sarno Federica , Coronnello Claudia , De Rosa Maria , Cipollina Chiara , Altucci Lucia , Perricone Ugo , Alfano Caterina 
Published: December 2023

Abstract
Background
Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an important role in the epigenetic dysregulation in various cancers and is linked to aggressive disease and poor clinical outcomes. Despite several efforts, the KDM4 family lacks successful specific molecular inhibitors.

Results
Herein, starting from a structure-based fragments virtual screening campaign we developed a synergic framework as a guide to rationally design efficient KDM4A inhibitors. Commercial libraries were used to create a fragments collection and perform a virtual screening campaign combining docking and pharmacophore approaches. The most promising compounds were tested in-vitro by a Homogeneous Time-Resolved Fluorescence-based assay developed for identifying selective substrate-competitive inhibitors by means of inhibition of H3K9me3 peptide demethylation. 2-(methylcarbamoyl)isonicotinic acid was identified as a preliminary active fragment, displaying inhibition of KDM4A enzymatic activity. Its chemical exploration was deeply investigated by computational and experimental approaches which allowed a rational fragment growing process. The in-silico studies guided the development of derivatives designed as expansion of the primary fragment hit and provided further knowledge on the structure–activity relationship.

Conclusions
Our study describes useful insights into key ligand-KDM4A protein interaction and provides structural features for the development of successful selective KDM4A inhibitors.
Reducing fall injuries with better data
Authors: Hemenway David , Peterson Elizabeth W. , Howland Jonathan 
Published: December 2023

Abstract
Background
Fall deaths in the USA almost tripled in the twenty-first century. While various interventions have been effective in reducing fall deaths, they have failed to make a substantial impact at a population level.

Main body
An overarching factor that has been relatively neglected in fall injury prevention is the need for more and better data. We need better data on the causes and circumstances of older adult fall deaths. While there are excellent national surveillance systems on the circumstances of other injury deaths (e.g., motor vehicle crashes, suicides, and homicides), such a system is lacking for fall deaths. These other data systems have been instrumental in indicating and evaluating policies that will reduce injury. It is also important to provide consumers with better information concerning the many products that affect the likelihood of fall injury (e.g., flooring, hip protectors, footwear). Automotive buyers are provided with relevant up-to-date make-model safety information from crash tests and real-world performance. Such information not only helps protect buyers from purchasing dangerous products, but it provides producers with the incentive to make ever safer products over time.

Conclusion
We believe that creation of a national surveillance system on the circumstances of fall deaths, and increased testing/certifying of fall-related products, are two steps that would help create the conditions for continuous reductions in fall fatalities. Fall prevention should apply some of the same basic strategies that have proved effective in addressing other injuries.
Gut microbiota shifts favorably with delivery of handwashing with soap and water treatment intervention in a prospective cohort (CHoBI7 trial)
Authors: Monira Shirajum , Barman Indrajeet , Jubyda Fatema Tuz , Ali Sk. Imran , Islam Aminul , Rahman Kazi Mohammad Zillur , Rashid Mahamud-ur , Johura Fatema-Tuz , Sultana Marzia , Zohura Fatema , Bhuyian Sazzadul Islam , Parvin Tahmina , Sack David , Ahmed Tahmeed , Saif-Ur-Rahman K M , Hossain Maqsud , Watanabe Haruo , George Christine Marie , Alam Munirul 
Published: December 2023

Abstract
Background
Cholera can result in the expulsion of important microbiota from the gut and result in death if left untreated. The disease transmits mainly via drinking water carrying Vibrio cholerae; and household contacts (HHC) of cholera patients are at elevated risk during the first week of infection. The gut microbiota profiles of HHC-children of cholera patients at Dhaka city slums were investigated before (day 0) and after (day 8) delivery of chlorinated water as part of the major study ‘CHoBI7 trial (cholera-hospital-based intervention for 7 days)’.

Result
Results of sequencing and analysis of bacterial community DNA revealed the predominance of two bacterial phyla: Bacteroidetes and Firmicutes at day 0 with a relative abundance of 62 ± 6 (mean ± SEM%) and 32 ± 7, respectively. The pattern reversed at day 8 with a decreased relative abundance of Bacteroidetes (39 ± 12; p = 0.034) and an increased abundance of Firmicutes (49 ± 12; p = 0.057). Of 65 bacterial families confirmed at day 0, six belonging to Proteobacteria including Vibrionaceae disappeared at day 8. Interestingly, the relative abundance of four Firmicutes families—Lachnospiraceae, Bifidobacteriaceae, Clostridiaceae, and Ruminococcaceae was increased in all five study children at day 8.

Conclusion
The observed exclusion of pathogenic Proteobacteria and enhancement of beneficial Firmicutes in the gut of children delivered with chlorinated water as part of WASH intervention reflect a great promise of the CHoBI7 program in preventing cholera and improving child health.
Three cases of mushroom poisoning with an unexpected initial presentation: acute kidney injury with Amanita proxima poisoning
Authors: Aydın Mehmet Fethullah , Sezen Mehmet , Oruç Aysegül , Yıldız Abdülmecit , Özerik Kübra , Aslan Hatice , Özgü Can , Kuş Elif Özge , Kahveci Ferda , Ersoy Alparslan 
Published: December 2023

Abstract
Background
Mushroom poisoning causes common gastrointestinal symptoms such as nausea and vomiting and is a well-known reason for acute hepatic failure. Acute kidney injury is a less common clinical presentation in mushroom poisoning. Recently, nephrotoxicity called Amanita nephrotoxic syndrome has been defined, caused by several Amanita mushrooms. It is characterized by moderate hepatotoxicity and oligoanuric acute kidney injury, which may require hemodialysis.

Case presentation
Case 1 was a 51-year-old female patient who was hospitalized with oliguria, nausea, and vomiting after eating mushrooms, required hemodialysis due to acute kidney injury, and developed pulmonary hemorrhage during her follow-up. Case 2 was a 55-year-old male patient who was hospitalized with anuria, nausea, and vomiting after eating mushrooms, required hemodialysis due to acute kidney injury, and developed acute coronary syndrome during his follow-up. Case 3 was a 59-year-old male patient who was hospitalized with oliguria, nausea, and vomiting after eating mushrooms, required hemodialysis due to acute kidney injury, and developed moderate hepatotoxicity during his follow-up. All cases were hospitalized at the same time interval with similar clinical features. Acute kidney injury was the initial presentation of all the cases, and they had only mild transaminase elevation with normal INR levels. They all required hemodialysis, and kidney injury was fully recovered.

Conclusions
Mushroom consumption must be questioned in acute kidney injury patients of unknown etiology where mushrooms are habitual despite deleterious consequences.
Pathogenic Germline Mutational Landscape in Patients With Renal Cell Carcinoma and Associated Clinicopathologic Features
Authors: Nguyen Charles B. , Knaus Claire , Li Jinju , Accardo Marie-Louise , Koeppe Erika , Vaishampayan Ulka N. , Alva Ajjai S. , Else Tobias 
Published: December 2023

PURPOSE A subset of renal cell carcinoma (RCC) cases occur because of a hereditary predisposition. However, the prevalence and profiling of germline alterations in RCC have not been fully characterized. Additionally, clinicopathologic factors associated with pathogenic or likely pathogenic (P/LP) germline variants in patients with RCC remain poorly understood. METHODS A retrospective analysis of patients with RCC who underwent genetic evaluation was performed. The frequency of P/LP germline variants and genes was evaluated in this cohort. The association between genetic testing outcomes and clinicopathologic features was also assessed. RESULTS A total of 321 patients with RCC who had germline testing were identified. Within this cohort, 42 patients (13.1%) had P/LP variants. Genes with the most frequent germline mutations were FLCN (n = 10, 3.1%), SDHB (n = 4, 1.2%), VHL (n = 4, 1.2%), MLH1 (n = 3, 0.9%), and CHEK2 (n = 4, 1.2%). Among patients with P/LP variants, 19 (45.2%) had a potentially targetable mutation. The presence of bilateral or multifocal tumors was associated with P/LP variants ( P = .0012 and P = .0098, respectively). Patients who had targeted gene testing had higher rates of P/LP variants compared with multigene panel testing ( P = .015). Age and family history of cancers (RCC and non-RCC) did not have any statistically significant association with germline testing outcomes. CONCLUSION Among patients with RCC, unselected for a known familial predisposition, 13.4% had P/LP variants. Almost half of patients with P/LP variants had a potentially targetable mutation. Targeted gene panel testing is a feasible option for patients, particularly if syndromic features are present. Age and family history were not associated with P/LP variants. Future studies are needed to optimize current genetic evaluation criteria to expand the detection of patients with RCC who may have germline mutations.
Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome
Authors: Li Sheng , Ying Zhixiong , Gentenaar Max , Rensen Patrick C N , Kooijman Sander , Visser Jenny A , Meijer Onno C , Kroon Jan 
Published: December 2023

Abstract

Context
Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with obesity, insulin resistance, and dyslipidemia. Hyperandrogenism is a major characteristic of PCOS. Increased androgen exposure is believed to deregulate metabolic processes in various tissues as part of the PCOS pathogenesis, predominantly through the androgen receptor (AR). Notably, various metabolic features in PCOS are similar to those observed after excess glucocorticoid exposure.

Objective
We hypothesized that glucocorticoid receptor (GR) signaling is involved in the metabolic symptoms of PCOS.

Methods
In a PCOS model of chronic dihydrotestosterone (DHT) exposure in female mice, we investigated whether GR signaling machinery was (de)regulated, and if treatment with a selective GR antagonist alleviated the metabolic symptoms.

Results
We observed an upregulation of GR messenger RNA expression in the liver after DHT exposure. In white adipose tissues and liver we found that DHT upregulated Hsd11b1, which encodes for the enzyme that converts inactive into active glucocorticoids. We found that preventive but not therapeutic administration of a GR antagonist alleviated DHT-induced hyperglycemia and restored glucose tolerance. We did not observe strong effects of GR antagonism in DHT-exposed mice on other features like total fat mass and lipid accumulation in various tissues.

Conclusion
We conclude that GR activation may play a role in glucose metabolism in DHT-exposed mice.
Mythography and Archaeology: The Case of Eulimene
Authors: Astyrakaki Eva 
Published: December 2023

The main aim of the present research work is to provide a new interpretative perspective on Eulimene’s story by combining literary testimonies and archaeological findings. The story is included in Parthenius’s collection entitled Περὶ Ἐρωτικῶν Παθημάτων, dating back to the 1st century BC. This story appears to be an exceptionally fertile example in which a multidisciplinary approach, that combines Philology and Archaeology, can, potentially, illuminate aspects and facts that would otherwise remain unearthed.
Eulimene’s story deals with eponymous heroes and city founders of Crete. The Cretan cities of Lykastos and Kydonia are attested as early as in Homer and Aptera and Kydonia are also cited in Linear B tablets of Knossos; the name of Eulimene, referring to a Nereid, and the adjective ἄπτερος, applied to some gods, were known to Hesiod and Homer, respectively. Given that Crete was sui generis in terms of its own mythology, it is likely that before Homer there was already a background relating to those Cretan cities.
Eulimene is known as a Nereid. Hesiod reports it in his Theogony and pottery as early as the 5th c. BC attests it, as well. A different perspective is introduced by a piece of textile and a pyxis, which hint at an association of Eulimene with Crete, particularly with Phaedra and Ariadne.
There is also a Messenian story, reported by Pausanias, which presents similarities and common patterns. However, the story of Eulimene is rather more complex since the Messenian story was arguably modelled on the predating Cretan version.
Eulimene’s story in Parthenius’ collection was structured according to the aesthetic standards of the Hellenistic era. However, the story seems to combine various elements, some of which echo Minoan times (the ritual of human sacrifice carried out by the king-priest, a union designed to result in fertility, interrupted in this case) and others which echo archaic times (dissection and forced extraction of the baby). Thus, I find particularly interesting the archaeological finding of the cut-up skull of a young girl, which Andreadaki-Vlazaki brought to light during the excavation at the Mycenaean palace of Kydonia at Chania.
DEVELOPMENT OF A MATHEMATICAL MODEL FOR ANALYZING THE ECONOMIC EFFECT OF THE MODIFIED DESIGN OF A RADIAL SLIDING BEARING AND ITS PREDICTION
Authors: Morozova Anna V. , Mukutadze Murman A. 
Published: December 2023

In modern heavy-loaded friction units, various types of antifriction coatings are used on the surface of the bearing profile of the bearing sleeve to ensure high load-bearing capacity and increase the duration of the hydrodynamic regime, and consequently, the economic effect of sliding bearings.
In the study, the creation and development of mathematical models of a radial sliding bearing with an antifriction polymer coating of the support surface containing a groove is carried out. The key role here is played by the method of analytical forecasting, which determines the mechanism of friction and the conditions for its transition from boundary to liquid.
The aim of the study is to develop a mathematical model of a radial sliding bearing with a polymer coating of the bearing sleeve bearing surface containing an axial groove to predict the economic effect.
The objective of the study is to develop new mathematical models and analyze the movement of lubricant in the working gap of a radial sliding bearing, taking into account design features to predict the economic effect.
The difference from the existing models of tribosystems with antifriction coatings is the presence of a groove, which ensures stable ascent of the shaft on the hydrodynamic wedge and reduces wear during start-up and run-outs, hence increasing the service life of tribosystems.
Using the lubricant motion equation and the continuity equation, new mathematical models are obtained that take into account the design features of the bearing sleeve surface – polymer coating, groove width, rheological properties of the lubricant used. Based on the results of an experimental study on the AI 5018 friction machine, the economic efficiency of net discounted income was calculated on samples in the form of partial inserts.
As a result of the research, new mathematical models for engineering calculations have been developed that allow predicting the efficiency, reliability and duration of the hydrodynamic lubrication regime, as well as determining the main tribotechnical parameters. Net discounted income based on the results of theoretical and experimental research is estimated at 0.36 million rubles per year.
CONTEXTUAL COMMUNICATION AS A TOOLKIT FOR INCREASING PROFESSIONAL EFFECTIVENESS AND INTERPERSONAL COMMUNICATION
Authors: Gilmanov Timur A. , Naumov Petr Y. 
Published: December 2023

Introduction. The use of various types and forms of communication in communication activities is of certain research interest and can be learned through appropriate procedures. Unlocking the potential of contextual communication for professional and personal communication is the subject of this article.
Materials and methods. To carry out this research as an effective epistemological practice, a systemic and axiological approach was applied, as well as a set of modern methods for processing scientific information from various fields of social and humanitarian knowledge. These are various variations of the use of the analytical-synthetic method, making analogies and comparisons, mental movement in deductive and inductive ways, generalization of scientific data and theoretical abstraction.
Research results. The work consistently reveals the goals, objectives, structure, essence and concept of contextual communication based on the need for its implementation in professional activities and other forms of human interaction. It is noted that the main characteristic of contextual communication is its indirectness from direct communication, when the role of “subject-object of an example” is a real-life person, his actions (deeds) or examples of erroneous decisions. Through the mediation of contextual communication, it is possible to effectively transmit goal settings, value formations or epistemological constructs.
Discussions and conclusions. The construction of work communication processes and the increasing shortage of time resources for personal communication in modern reality actualizes the problems of using increasingly effective and quickly applied communication tools. Such a tool today also includes contextual communication, which is used purposefully or spontaneously both in business interaction between people and in personal subject-subject communication. Knowledge of contextual communication has great cognitive prospects, the achievement of which was carried out in this work.
NOTA RETRAKCYJNA 1
Authors: Gackowski Jacek 
Published: December 2023

NOTA RETRAKCYJNA
Andrzej Sokala
Wydawca Czasopisma Acta Universitatis Nicolai Copernici

Jacek Gackowski
Redaktor Naczelny czasopisma Acta Universitatis Nicolai Copernici – Archeologia

Unieważniamy artykuł Jacka Rakoczego pt. „ZAPINKI PROWINCJONALNORZYMSKIE ODKRYTE NA STANOWISKU 30 W PERKOWIE NA KUJAWACH, opublikowany w 2017 roku w XXXV tomie Acta Universitatis Nicolai Copernici – Archeologia (s. 25-40).

Podstawa retrakcji: naruszenie praw autorskich innego autora
DOI https://doi.org/10.12775/AUNC_ARCH.2017.011
Wycofany artykuł pozostanie na stronie internetowej czasopisma, oznaczony informacją o retrakcji.
Student midwives' experiences of clinical placement and the decision to enter the professional register
Authors: McNeill Maria , Kitson-Reynolds Ellen 
Published: December 2023

Background/Aims In addition to the high rate of attrition among registered midwives, student midwives are increasingly likely to choose to leave their programme, decreasing the projected number of midwives who would join the NHS. The aim of this study was to understand how students experience clinical practice and if these experiences affect their decision to enter the professional register. Methods Seven student midwives who had experienced clinical placement as part of their pre-registration training were invited to attend semi-structured interviews. Data were analysed following an interpretive phenomonology approach, where descriptive, linguistic and conceptual comments on the transcripts were used to identify emergent themes. Results The 79 identified themes were categorised into five sub-themes within two super-ordinate themes: ‘kindness and compassion grows future midwives and strength’ and ‘resolve through COVID-19 and beyond’. The overarching theme from the participants' interviews was ‘I can be a good midwife when I qualify’. Conclusions Students want to feel like they will be good midwives, which will be achieved with positive attitudes and behaviours towards them from senior staff during clinical placements. Staff involved with the care of women and newborns should ensure they show students civility and patience while teaching and supporting them. Understanding the level of knowledge that students possess can make it simpler for staff to recognise what each student may or may not have been exposed to.