bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes
Authors: Poblete Roy A. , Pena Jesus E. , Kuo Grace , Tarzi Fawaz , Nguyen Peggy L. , Cen Steven Y. , Yaceczko Shelby , Louie Stan G. , Lewis Meghan R. , Martin Matthew , Amar Arun P. , Sanossian Nerses , Sung Gene , Lyden Patrick D. 
Published: November 2023

Abstract

Background
Early evidence-based medical interventions to improve patient outcomes after traumatic brain injury (TBI) are lacking. In patients admitted to the ICU after TBI, optimization of nutrition is an emerging field of interest. Specialized enteral nutrition (EN) formulas that include immunonutrition containing omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been developed and are used for their proposed anti-inflammatory and pro-immune properties; however, their use has not been rigorously studied in human TBI populations.
Methods
A single-center, retrospective, descriptive observational study was conducted at LAC + USC Medical Center. Patients with severe TBI (sTBI, Glasgow Coma Scale score ≤ 8) who remained in the ICU for ≥ 2 weeks and received EN were identified between 2017 and 2022 using the institutional trauma registry. Those who received immunonutrition formulas containing n-3 PUFAs were compared to those who received standard, polymeric EN in regard to baseline characteristics, clinical markers of inflammation and immune function, and short-term clinical outcomes.
Results
A total of 151 patients with sTBI were analyzed. Those who received immunonutrition with n-3 PUFA supplementation were more likely to be male, younger, Hispanic/Latinx, and have polytrauma needing non-central nervous system surgery. No differences in clinical markers of inflammation or infection rate were found. In multivariate regression analysis, immunonutrition was associated with reduced hospital length of stay (LOS). ICU LOS was also reduced in the subgroup of patients with polytrauma and TBI.
Conclusion
This study identifies important differences in patient characteristics and outcomes associated with the EN formula prescribed. Study results can directly inform a prospective pragmatic study of immunonutrition with n-3 PUFA supplementation aimed to confirm the biomechanistic and clinical benefits of the intervention.
Human Capital Spillovers and Plant Productivity in ASEAN: Evidence from the Plant Panel Data
Authors: Rindimajangga Muhammad Arditya 
Published: November 2023

Abstract
This paper examines whether the local human capital spillovers can affect plant productivity in three ASEAN countries using panel data from World Bank Enterprise Survey between 2009 and 2015. The spillovers exist if plants can produce more in the region with the abundant number of skilled workers given their inputs. This study focuses on the proportion of nonproduction workers outside the plant as the proxy of skilled workers. I use augmented Cobb-Douglas production function to estimate this effect. Results suggest that human capital spillovers do matter for plant productivity. I find that a 1 percent increase in the proportion of nonproduction workers within a region will enhance the productivity of plants in that region by roughly 7.1–8.9 percent. Moreover, the productivity rises are found to be higher for low-tech plants. The economic value of such spillovers effect indicates that per plant value-added will increase by US$ 330,000 or correspondingly, an increase of US$ 866.75 million for the whole manufacturing industry.
JEL codes: D24, J24, L25, L60
Obtaining a multi-organization OMOP CDM repository from two heterogeneous EHR ecosystems: a flexible methodology based on Detailed Clinical Models
Authors: Pedrera-Jimenez Miguel , Frid Santiago , Garcia-Barrio Noelia , Bracons-Cuco Guillem , Bosca-Tomas Diego , Moner-Cano David , Muñoz-Carrero Adolfo , Serrano-Balazote Pablo 
Published: November 2023

Abstract
Background
Standardized repositories of real-world data provide a mechanism for semantic convergence of data from different heterogeneous organizations for secondary use. However, it is common for these repositories to be populated from locally designed information systems, which generates inefficient processes that are not reusable in other organizations or projects.
Objective
Design and application of a methodology based on the Detailed Clinical Models (DCM) paradigm for allowing the flexible and harmonized implementation of a real world-data (RWD) repository from two technically and organizationally heterogeneous EHR ecosystems.
Material and methods
First, the DCM paradigm was used for the design of common information objects. Second, a set of clinical archetypes were implemented according to ISO 13606 standard. Third, an OMOP CDM muti-organization repository was implemented for COVID-19 research. Finally, the quality of the data obtained with the aforementioned process was evaluated.
Results
The main result was the proposal of a methodology for obtaining harmonized EHR-derived datasets using clinical archetypes as a convergence mechanism between local organization-dependent EHR designs. In addition, the application of this method also generated a set of reusable implementation results: (1) the catalog of clinical archetypes, (2) the definition of the transformation process from the archetypes to the OMOP CDM model, and (3) the EHR-derived dataset obtained.
Conclusions
The flexibility of the methodology made possible the adoption by two digitally mature tertiary hospitals, without altering the platforms already in place. Likewise, the method is agnostic to organizations, to persistence and exchange standards to be obtained, and to application health conditions. Therefore, it can be concluded that the implemented methodology constitutes an innovative and transferable solution to obtain RWD datasets in an efficient, flexible and reusable way.
Mixed responses of ant assemblages to Carpobrotus spp. and Rattus rattus eradications on a small Mediterranean island
Authors: Blaya Romane , Blight Olivier , Aurelle Sébastien , Ponel Philippe , Buisson Elise 
Published: November 2023

Abstract
Eradication of invasive alien species (IAS) is often proposed to restore invaded ecosystems, with information on subsequent ecosystem recovery key to conservation policies. Although ants perform major ecological functions in the ecosystem, their response to IAS eradication has received relatively little monitoring. This study investigated ant response to Carpobrotus spp. (iceplant) and R. rattus (black rat) eradications on the small Mediterranean island of Bagaud (Var, France). Ant assemblages were monitored over a ten-year period, including two years before eradications, at six different sites, two invaded by Carpobrotus spp., two under high R. rattus pressure, and two control sites. We found inter-annual variations in ant assemblages but no before-after eradication trend at both control and rat eradication sites. However, there was a clear increase in ant species richness and abundance after the Carpobrotus eradication. A trend toward more homogeneous assemblages was observed, with an enhanced core of common Mediterranean ant species. Xerophilous and thermophilous species such as Pheidole pallidula, Messor bouvieri, and Plagiolepis pygmaea were more abundant, consistent with the return of native vegetation communities and possibly warmer and dryer microclimatic conditions. The trend was even stronger on the denser and thicker Carpobrotus eradication patch. Increased ant foraging activity is a good sign of restoration success, influencing different functions of the ecosystem, such as seed dispersal or nutrient cycling.
Analysis of the Resistance of Small Peptides from Periplaneta americana to Hydrogen Peroxide-induced Apoptosis in KGN Cells based on High-throughput miRNA Sequencing
Authors: Jiang Rong , Sun Ruixian , Tang Yunping , Sui Shiyan 
Published: November 2023

Abstract
Background: Apoptosis of ovarian granulosa cells can promote abnormal atresia folliculin and decrease women's reproductive function. MiRNA plays an essential molecular signal-regulating function in ovarian functional development, animal reproductive performances and follicular development. The purpose of this study is to investigate the miRNA molecules and action pathways during the resistance of small peptides from Periplaneta americana (SPPA) resistance to peroxide-induced ovarian granulosa cells (KGN cells) apoptosis.
Results: The study found that 162 differentially expressed miRNAs were identified in the blank control group, H2O2 group and H2O2+SPPA group. The intersection of miRNAs between the three groups was determined, through which 13 differentially expressed miRNAs were identified. Target gene prediction of differentially expressed miRNAs yielded 4828 target genes. Finally, GO and KEGG analysis were performed on 4828 target genes. The target genes primarily engaged in transcription, DNA template, negative transcriptional regulation of RNA polymerase II promoter, negative regulation of cell proliferation, protein binding, metabolic pathways, and mitogen-activated protein kinase signalling pathways. After qRT-PCR verification, expression trends of miR-103a-3p and miR-214 were consistent with sequencing results.
Conclusions: Critical miRNAs have been identified as miR-103a-3p and miR-214 in SPPA resistance to peroxide-induced KGN apoptosis.
Iterative Sparse Identification of Nonlinear Dynamics
Authors: Choi Jinho 
Published: November 2023

Abstract
In order to extract governing equations from time-series data, various approaches are proposed. Among those, sparse identification of nonlinear dynamics (SINDy) stands out as a successful method capable of modeling governing equations with a minimal number of terms, utilizing the principles of compressive sensing. This feature, which relies on a small number of terms, is crucial for interpretability. The effectiveness of SINDy hinges on the choice of candidate functions within its dictionary to extract governing equations of dynamical systems. A larger dictionary allows for more terms, enhancing the quality of approximations. However, the computational complexity scales with dictionary size, rendering SINDy less suitable for high-dimensional datasets, even though it has been successfully applied to low-dimensional datasets. To address this challenge, we introduce iterative SINDy in this paper, where the dictionary undergoes expansion and compression through iterations. We also conduct an analysis of the convergence properties of iterative SINDy. Simulation results validate that iterative SINDy can achieve nearly identical performance to SINDy, while significantly reducing computational complexity. Notably, iterative SINDy demonstrates effectiveness with high-dimensional time-series data without incurring the prohibitively high computational cost associated with SINDy.
Detailed Immune Profiling in Pediatric Crohn's Disease Using Methylation Cytometry
Authors: Reynolds Samuel R. , Salas Lucas A. , Chen Ji-Qing , Christensen Brock C. 
Published: November 2023

Abstract
DNA methylation has been extensively utilized to study epigenetic patterns across many diseases as well as to deconvolve blood cell type proportions. This study builds upon previous studies examining methylation patterns in pediatric patients with varying stages of Crohn’s disease to extend the immune profiling of these patients using a novel deconvolution approach. Compared with control subjects, we observed significantly decreased levels of CD4 memory and naive, CD8 naive, and natural killer cells and elevated neutrophil levels in Crohn’s disease. In addition, Crohn’s patients had a significantly elevated neutrophil-to-lymphocyte ratio. Using an epigenome-wide association approach and adjusting for potential confounders, including cell type, we observed 397 differentially methylated CpG (DMC) sites associated with Crohn’s disease. The top genetic pathway associated with the DMCs was the regulation of arginine metabolic processes which are involved in the regulation of T cells.
Spontaneous Bowel Perforation in Asymptomatic SARS-COV-2 Patient
Authors: Wijesinghe Vindya 
Published: November 2023

Abstract
BACKGROUND
Gastrointestinal (GI) symptoms are common in SARS-CoV-2 patients. In addition, life-threatening complications have started to report from patients with severe SARS-CoV-2 infection. We are reporting the morbid large bowel perforation in an asymptomatic patient with SARS-CoV- 2.
CASE HISTORY
She was a 52-year-old healthy woman who developed an acute abdomen and developed septic shock before admission. Severe fecal contamination was noted at the time of laparotomy. She was not responded to resuscitative measures and expired after a few hours of admission. Her histology shows features of mesenteric ischemia.
CONCLUSION
SARS-CoV-2 infection is often mild. However, mesenteric ischemia and subsequent complication often develop in patients with severe SARS-CoV-2 infection, which require intensive care admissions. Abdominal pain in such patients is frequently taken seriously and further investigated. However, asymptomatic patients with mesenteric ischemia can be diagnosed late, leading to loss of lives.
ENVIRONMENTAL FLOW ASSESSMENT MODEL ON SUSTAINABILITY PLANNING STRATEGIES, KENYIR LAKE BASIN, MALAYSIA
Authors: Abd Wahab Noorjima , Kamarudin Mohd Khairul Amri , Al Qassem Amer , Rahayu Mia , Mamat Ahmad Fadhli 
Published: November 2023

The study presents the Environmental Flow Assessment (EFA) model on sustainability planning strategies to reduce damage in the main area of Kenyir Lake Basin. The XPSWMM model have been used to simulate the EFA in this study. Based on simulation in the Terengganu River, which has a most effective discharge of 42.78 m3/s with depth on 3.94 m and a water velocity of 0.54 m/s, which are expected to meet the development needs of fish species, the analysis for both study rivers found the minimum river discharge values with the frequency probability in the period of 20 years needs to be maintained. While, based to the simulation in the Petuang River, the maximum discharge is only 0.08 m3/s, the maximum depth is 0.4 m, and the maximum water speed is 0.04 m/s, which is adequate for a small number of small-sized fish species. With output deficiency of less than 20% from an actual situation, the two lowest values later obtained were adopted as input in low flow analysis. A more effective management approach ensures the ecosystem's sustainability and maintains an optimal equilibrium among the many uses. Environmental flows aren't considered a luxury but instead an integral component of contemporary water management given the global misuse of water resources and the resulting degradation of ecosystems and their functions. It is a strategy that requires widespread adoption.
Experience of training and certification in pediatric disciplines of students majoring in 222 “medicine” specialty
Authors: Volosovets O.P. , Naumenko O.M. , Tsymbaliuk R.S. , Kryvopustov S.P. , Grischenko N.V. , Mozyrska O.V. , Loginova I.O. , Shevtsova T.I. , Chernii O.F. , Saltanova S.D. , Kovalchuk O.L. , Kryvopustova M.V. 
Published: November 2023

Certification of graduates of the Faculty of Medicine 2 of the National Medical University (NMU) in pediatric disciplines was conducted by the Department of Pediatrics 2 at the objective structured practical (clinical) exam 2 (OSP(C)E-2) station “Initial and resuscitation care to a newborn child” on the basis of the Educational and Scientific Center of Medical Simulations of the NMU. The methodology that we introduced in 2022 in the Medical Education journal was presented and approved at the methodical meeting of the heads of departments of pediatrics of higher education institutions of Ukraine during the Sidelnikov readings. The data of an anonymous survey of graduates demonstrated that most respondents (93.4 % of domestic and 91.9 % of foreign ones) were satisfied with the volume of the station and its practical orientation. The students noted that during preparation to exam, this particular model of the station allows them to master, when using mannequins, manipulations according to the algorithm of initial and resuscitation care to a newborn child, which can be useful under various circumstances in wartime conditions. Out of 338 students of the Faculty of Medicine 2, 303 (89.6 %) passed the OSP(C)E-2 exam with an “excellent” grade, 32 (9.4 %) with a “good” grade, and 3 (0.9 %) with a “satisfactory” grade. The issue of optimality and adequacy of assessing only the skills in initial and resuscitation care to a newborn child at the OSP(C)E-2 exam remained deba­table among teachers. This corresponds to the opinion of 8.1 % of domestic and 6.6 % of foreign students who believe that for perfection and objectivity of pediatric skills assessment, it would be desirable to introduce one more pediatric station for the OSP(C)E-2 exam with the involvement of a virtual a patient of a different age. Experience of certification in pediatric disciplines of higher education graduates majoring in 222 “medicine” specialty at the Bogomolets National Medical University, both teachers and students, testified to its effectiveness and objectivity in assessing the special competencies of graduates in providing resuscitation care to a newborn child.
Clinical case of diagnosis of left ventricular non-compaction in a child
Authors: Kryuchko T.O. , Tanianska S.M. 
Published: November 2023

Diseases of cardiovascular system in children present an extremely urgent problem nowadays. According to the latest epidemiological studies, there has been an increase by almost 3.2 % in congenital heart disease in Ukrainian children over the past 20–30 years. Left ventricular non-compaction belongs to a group of unclassified cardiomyopathies with undetermined prevalence. At the same time, based on literature, this pathology is characterized by a late diagnosis and very high mortality. In the pathogenesis of the disease, structural changes in the myocardium occur during the embryonic stage, leading to its abnormal development. Left ventricular non-compaction is considered a genetically heterogenous disease, which is inherited in an autosomal dominant pattern. The article deals with a clinical case of diagnosis and management of a child with left ventricular non-compaction, which demonstrates to ge­neral practitioners, pediatricians, and pediatric cardiologists the algorithm for diagnosing and managing patients with a rare disease in order to make earlier diagnosis, prevent complications, and preserve patient’s life. The patient who has been suffered from pneumonia, complained of breathlessness and rapid fatigue during minor physical exertion was timely referred by the family doctor for consultation with a pediatric cardiologist. Laboratory and instrumental studies allowed to suspect a rare congenital heart disease — left ventricular non-compaction. Subsequently, the patient was regularly examined by cardiologists and cardiac surgeons, received protocol therapy, was registered in a state transplant registry, which allowed to wait for a donor with subsequent successful heart transplant surgery.
STRATEGI PEMBERDAYAAN MASYARAKAT MELALUI PROGRAM PENGELOLAAN SAMPAH DI BANK SAMPAH MAJU SELALU KELURAHAN MARUNDA JAKARTA UTARA
Authors: Stefany Indry , Rahmawati Isna 
Published: November 2023

Abstract: Garbage is a problem that needs attention, there are people who do not understand the problem of waste and waste management. This problem is also found in the community of RW 05 Marunda Village. In waste management, most people rely on (PPSU) and paid waste officers. The existence of the Forward Always Garbage Bank is a solution in changing the community's lifestyle. This study aims to determine the strategy and results of community empowerment carried out by the Maju Selalu Waste Bank. In this study the methodology used was a qualitative approach with a descriptive. Data collection techniques were obtained by means of observation, interviews and documentation, the data sources of which were primary data and secondary data. Data analysis techniques through data reduction, data presentation and drawing conclusions. The empowerment strategy carried out by the Maju Selalu waste bank consists of forming groups, mentoring which is seen from the function of the Maju Selalu waste bank as a facilitator, communicator, and dynamicator. The results of the empowerment carried out can help the community meet their daily needs and increase community capacity in waste management. The results of empowerment can refer to the ability of people so that they have the ability to meet basic needs, increase income and participate in the empowerment process.Keywords: Empowerment Strategy; Garbage; Garbage Bank.Abstrak: Sampah merupakan masalah yang perlu diperhatikan, terdapat manusia kurang mengerti mengenai permasalahan sampah dan pengelolaan sampah. Permasalahan tersebut juga terdapat pada masyarakat RW 05 Kelurahan Marunda. Dalam pengelolaan sampah kebanyakan masyarakat mengandalkan (PPSU) dan petugas sampah berbayar. Adanya Bank Sampah Maju Selalu sebagai solusi dalam mengubah pola hidup masyarakat tersebut. Penelitian ini bertujuan untuk mengetahui strategi dan hasil pemberdayaan masyarakat yang dilakukan oleh Bank Sampah Maju Selalu. Pada penelitian ini metodologi yang digunakan yaitu pendekatan kualitatif dengan jenis deskriptif, teknik pengumpulan data diperoleh dengan cara observasi, wawancara dan dokumentasi yang sumber datanya berupa data primer dan data sekunder. Teknik analisis data melalui reduksi data, penyajian data dan penarikan kesimpulan. Strategi pemberdayaan yang dilakukan oleh Bank sampah Maju Selalu terdiri dari pembentukan kelompok, pendampingan yang dilihat dari fungsi Bank Sampah Maju Selalu sebagai fasilitator, komunikator, dinamisator. Serta strategi dalam perencanaan kegiatan. Hasil dari pemberdayaan yang dilakukan dapat membantu masyarakat dalam memenuhi kebutuhan sehari-hari dan meningkatkan kapasitas masyarakat dalam pengelolaan sampah. Adapun hasil dari pemberdayaan dapat merujuk pada kemampuan orang sehingga mereka memiliki kemampuan dalam memenuhi kebutuhan dasar, meningkatkan pendapatan dan berpartisipasi dalam proses pemberdayaan.Kata Kunci: Strategi Pemberdayaan; Sampah; Bank Sampah.
Optimization of Ready-to-Cook Chicken Cutlet Mix Using Different Levels of Antioxidant Dietary Fiber Enriched Dehydrated Vegetable Mix
Authors: Tomar Serlene , Chauhan Geeta , Das Annada , Meshram Somesh 
Published: November 2023

A study was conducted during a period of six (6) months from June to December, 2019 at the Division of Livestock Products Technology, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India to develop a nutritious, convenience and shelf stable ready-to-cook chicken cutlet mix extended with dried vegetables as a source of antioxidant dietary fiber. Dehydrated vegetable mix was added at three different levels (2.5, 5 and 7.5%) and compared with control having no added vegetables. The results revealed that the dehydrated vegetable mix proved to be an additional source of minerals and dietary fibre in the chicken cutlet mix. Extension of ready-to-cook cutlet mix improved the yield, and colour saturation of the mix. The chicken cutlets prepared using the extended mix offered improved juiciness and overall acceptability along with better textural profile. Physico-chemical analysis revealed that the mix was shelf stable due to its low water activity and moisture content and hence could probably be stored for long periods of time. Extension of the mix with DVM enhanced the functionality of the product by improving its antioxidant potential. However, as indicated by sensory evaluation higher levels of dehydrated vegetables (7.5%) altered the colour, texture and flavour of developed product. Hence, 5% level of DVM was found to be the most suitable level for extension of the ready-to-cook mix. Therefore, extension with dehydrated vegetables could serve to meet technological and functional properties in the development of convenient, nutritious and tasty ready-to-cook dehydrated mix, which could serve an alternative to fresh meat cutlets.