bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direction-dependent conductivity in planar Hall set-ups with tilted Weyl/multi-Weyl semimetals
Authors: Mandal Ipsita , Ghosh Rahul 
Published: February 2024

Abstract
We compute the magnetoelectric conductivity tensors in planar Hall set-ups, which are built with tilted Weyl semimetals (WSMs) and multi-Weyl semimetals (mWSMs), considering all possible relative orientations of the electromagnetic fields (E and B) and the direction of the tilt. The non- Drude part of the response arises from a nonzero Berry curvature in the vicinity of the WSM/mWSM node under consideration. Only in the presence of a nonzero tilt do we find linear-in-|B| terms in set-ups where the tilt-axis is not perpendicular to the plane spanned by E and B. The advantage of the emergence of the linear-in-|B| terms is that, unlike the various |B|2-dependent terms that can contribute to experimental observations, they have purely a topological origin and they dominate the overall response-characteristics in the realistic parameter regimes. The important signatures of these terms are that (1) they change the periodicity of the response from π to 2π, when we consider their dependence on the angle θ between E and B; and (2) lead to an overall change in sign of the conductivity depending on θ, when measured with respect to the B = 0 case.
Requirements and designing method of optics for self-mixing sensor in presence of speckle
Authors: Sin Tong-Myong , Kim Hyok-Chol , Kim Chol-Hyon , Song Un-Hyok , Ho Kwang-Myong 
Published: February 2024

Abstract
Since the surface of the target which the self-mixing interferometric displacement sensor encounters generally is rough, the sensor is always affected by speckle effect. Although the speckle has an effect on the quality of the self-mixing signal, we have found for the first time that the speckle puts forward an important requirement for the optical system of the sensor. In the paper we have also presented a design method of the optical system for the self-mixing displacement sensor which can provide variable measurement distance. The methods and results reported will give deeper understanding of self-mixing phenomenon and be of great help to improving the performance of the self-mixing sensor.
SORCHIC: Second Order Reversible Cellular Automata based Hybrid Image Cipher for IoT applications
Authors: Rao Vijaya Bhaskara , Rawat Umashankar , Roy Satyabrata , Upadhyay Utsav 
Published: February 2024

Abstract

In the rapidly evolving digital world, ensuring secure data transmission, especially in image data pivotal to modern communication, remains critical. The Internet of Things (IoT) amplifies the need for encryption systems that blend robust security with efficiency. However, current cryptosystems often compromise one for the other. To address this, emerging algorithmic techniques aim to strike a balance. Among these, First Order Cellular Automata (FOCA) show promise for image encryption, aligning seamlessly with image processing intricacies while maintaining lower implementation complexity. This paper introduces SORCHIC, a novel hybrid encryption algorithm designed specifically for IoT applications encrypting multichannel images. Leveraging Second-Order Cellular Automata (SOCA) and Chaotic Maps, SORCHIC undergoes comprehensive exploration within this work. Detailed insights into its inner workings are provided, followed by a rigorous experimental analysis comparing it to existing encryption methods. The results underscore SORCHIC’s resilience against diverse cryptanalysis attacks and highlight its superior efficiency compared to established techniques. This study contributes to advancing encryption methods, particularly in IoT, by presenting a robust, efficient, and secure approach tailored for image data transmission.
Assessment of anthropogenic and climate-driven water storage variations over water-stressed river basins of Ethiopia
Authors: Yoshe Agegnehu Kitanbo 
Published: February 2024

Abstract
Globally, surface water, groundwater, soil moisture, snow storage, canopy water, and wet biomass constituents make up water storage, which plays a significant role in the hydrological water balance. Evaluating the variations in water storage anomalies associated with climate forcing and human activities over river basins is crucial for assessing water scarcity and predicting potential pressures on water resources in the future. In this study, we assessed the impacts of climatic and anthropogenic drivers on the change in water storage in the river basins of Ethiopia by using the independent component analysis to examine Gravity Recovery and Climate Experiment with the Global Land Data Assimilate System-based water storage and comparing the independent component analysis with hydro-meteorological data and statistical data related to human activities. It is of great significance for helping people better understand the evaluation of terrestrial water storage anomalies under the combined influence of climatic change and anthropogenic activities and providing information for better protection and utilization of water resources at river basin level. It is crucial to take effective measures to protect these precious land and water resources and prevent their further deterioration. The estimated result will be essential for sustainable water management and protection.
Interleukin 6 Antagonists in Severe COVID-19 Disease: Cardiovascular
and Respiratory Outcomes
Authors: Khan Shahzad 
Published: February 2024

Background::
Inhibitors of interleukin 6 [IL-6] have been utilized to treat severe
COVID-19 disease. Their immunosuppressive or immunomodulating impact may be beneficial in
COVID-19.

Objectives::
To discuss the role of IL-6 inhibitors and assess various trials conducted to evaluate
the efficacy of IL-6 inhibitors in COVID-19 disease.

Summary::
Two of the most common causes of mortality in COVID-19-infected critically ill individuals
are acute respiratory distress syndrome (ARDS) and multiorgan failure. Increased levels
of inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome
(CRS), is involved in the etiology of COVID-19. Most tissue damage, sepsis, and pulmonary
and cardiovascular problems are caused mainly by the host defense system. Therefore, regulating
this inflammatory cascade using immunomodulators is a prudent strategy. Although corticosteroids,
as immunomodulators, are routinely used in COVID-19 management, interleukin (IL)
inhibitors, especially IL-6 inhibitors, are also tested in many trials. Many studies have demonstrated
that IL-6 inhibitors improve disease outcomes and decrease mortality, whereas others have
shown that they are ineffective. In this paper, we briefly examined the role of IL-6 in COVID-19
pathogenesis and trials that support or refute the use of IL-6 inhibitors in treating COVID-19 disease.

Results::
Though mixed results are coming from trials regarding the adjuvant use of IL-6 inhibitors
and standard anti-viral therapy with dexamethasone, a consensus favors using IL-6 inhibitors
in severely ill COVID-19 patients regardless of the outcome.
Natural Phenolic Compounds with Antithrombotic and Antiplatelet
Effects: A Drug-likeness Approach
Authors: Fernandes Diégina Araújo , Gomes Ayala Nara Pereira , da Silva Camila Macaubas , de Medeiros Henriques Isabelly Soares , de Menezes Renata Priscila Barros , Scotti Marcus Tullius , Teles Yanna Carolina Ferreira , Edrada-Ebel RuAngelie , de Fatima Vanderlei de Souza Maria 
Published: February 2024

Background:
Thrombosis is one of the major causes of morbidity and mortality
in a wide range of vessel diseases. Several studies have been conducted to identify antithrombotic
agents from medicinal plants, and phenolic compounds (PCs) have been
shown to effectively inhibit plasma coagulation and platelet aggregation.

Objectives:
This study aimed to conduct a survey of the natural PCs with proven antithrombotic
and antiplatelet activities, as well as to evaluate by computational modeling
the physicochemical and toxicological properties of these compounds using drug-likeness
approaches.

Methods:
The data were collected from the scientific database: ‘Web of Science’,
‘Scifinder’, ‘Pubmed’, ‘ScienceDirect’ and ‘Google Scholar’, the different classes of
PCs with antithrombotic or antiplatelet effects were used as keywords. These molecules
were also evaluated for their Drug-Likeness properties and toxicity to verify their profile
for being candidates for new antithrombotic drugs.

Results:
In this review, it was possible to register 85 lignans, 73 flavonoids, 28 coumarins,
21 quinones, 23 phenolic acids, 8 xanthones and 8 simple phenols. Activity records
for tannins were not found in the researched databases. Of these 246 compounds,
213 did not violate any of Lipinski's rules of five, of which 125 (59%) showed non-toxicity,
being promising candidates for new potential antithrombotic drugs.

Conclusion:
This review arouses interest in the isolation of phenolic compounds that
may allow a new approach for the prevention of both arterial and venous thrombosis,
with the potential to become alternatives in the prevention and treatment of cardiovascular
diseases.
Anti-Cancer and Anti-Oxidant Effects of Fenoferin-loaded Human
Serum Albumin Nanoparticles Coated with Folic Acid-bound
Chitosan
Authors: Almusawi Methaq Abid Said Klmohamed , Pouresmaeil Vahid , Tabrizi Masoud Homayouni 
Published: February 2024

Background::
Several diseases, including cancer, can be effectively treated
by altering the nanocarrier surfaces so that they are more likely to be targeted.

Objective::
This study aimed to prepare human albumin (HSA) nanoparticles
containing Fenoferin (FN) modified with folic acid (FA) attached to Chitosan (CS) to
improve its anti-cancer properties.

Methods::
Nanoparticles were first synthesized and surface modified. Their
physicochemical properties were assessed by different methods, such as FESEM,
FTIR, and DLS. In addition, the percentage of drug encapsulated was measured by
indirect method. Besides evaluating the cytotoxic effects of nanoparticles using the
MTT assay, the antioxidant capacity of FN-HSA-CS-FA was assessed using the ABTS
and DPPH methods. Nanoparticles were also investigated for their anti-cancer effects
by evaluating the expression of apoptosis and metastasis genes.

Results::
Based on this study, FN-HSA-CS-FA was 165.46 nm in size, and a uniform
dispersion distribution was identified. Particles were reported to have a zeta potential
of +29 mV, which is within the range of stable nanoparticles. Approximately 75% of FN
is encapsulated in nanoparticles. Cytotoxic assay determined that liver cancer cells
were most sensitive to treatment with an IC50 of 144 μg/ml. Inhibition of free radicals by
nanoparticles is estimated to have an IC50 value of 195.23 and 964 μg/ml, for ABTS
and DPPH, respectively. In the treatment with nanoparticles, flow cytometry results of
arresting the cells in the SubG1 phase and real-time qPCR results indicated increased
expression of caspases-3, caspase-8, and caspase-9 genes.

Conclusion::
According to this study, synthesized nanoparticles inhibited free radicals
and activated apoptosis in liver cancer cells, and the capability of these nanoparticles
to inhibit cancer cells was also confirmed. This formulation can, therefore, be used in
preclinical studies to test the efficacy of the drug.
PLGA, a Hauler for Anticancer Drugs: Review
Authors: Garg Anubhav , Komal  , Gupta Parul , Sachin  , Sharma Shubham , Kumar Shubham , Kumar Sushil , Urvashi  , Kaur Rupinder , Kriplani Priyanka , Guarve Kumar 
Published: February 2024

Abstract:
Polymers are the mainstay of drug delivery systems. They may be natural, semisynthetic,
or synthetic and used to program the release of drugs as per requirement. They are used to enhance
the bioavailability and hence solubility, stability, and site specificity, or to release to drug either in a
controlled, pulsatile, sustained, immediate release pattern. In the present review, we have discussed
the recent prose and patents of poly(lactic-co-glycolic acid) and PLGA applicability in preparing
formulations against cancer. Synthetic polymer, PLGA comprises monomers of glycolide and lactide
available in various grades with varying physicochemical properties thus serving the formulators to
fabricate preparations having designed release patterns. In this review, current literature and patents
of poly(lactic-co-glycolic acid); PLGA using anticancer preparations have been covered. PLGA has
demonstrated its potential as a polymer to program the release of drugs as a coating polymer and the
development of a matrix in various drug delivery systems. It can augment the bioavailability of the
drug reducing the toxicity/side effects and delivering the drug at the target site. The potential of
PLGA to transfer the drug may unclutter novel ways for therapeutic interventions in various tumors.
Role of Availability on Actual Purchase Behavior of Organic Food
Products: An Application of Theory of Planned Behavior
Authors: Painuly Poonam , Pachaury Prachi 
Published: February 2024

Aim:
This paper examines how consumers' purchase intentions and actual purchase behavior for organic food products are related to the moderating effect of availability and its relationship with those two variables.

Methods:
Using structural equation modeling, a structured survey of 250 participants revealed
that the three components of the theory of planned behavior-attitude, subjective norm, and perceived behavior control impacted consumers' purchase intentions.

Results:
Findings revealed a strong correlation between purchase intention and actual purchase behavior of the consumers towards organic products. Furthermore, it identifies a few areas for future
work that would benefit wholesalers, retailers, marketers, consumers, and scholars.

Conclusion:
Food provides indispensable nourishment, which leads to a healthy life. However, it
has recently come to light that many food products have become unhealthy due to farmers' excessive use of pesticides and chemical-based fertilizers, resulting in several illnesses. Currently, it has
been observed that many consumers are attracted to organic food that is healthy, tasty, and free
from chemicals, pesticides, and fertilizers. To increase the study's accuracy and utility, further research might be done on additional aspects, such as significant price premiums, a lack of knowledge, confidence in organic certification programs, and quality.
The Effective Sorting Technologies for Reducing Aflatoxins in Nuts and
Dried Figs in Turkey
Authors: Özçakmak Sibel , AlMatar Manaf , Akbulut Onur , Çetinkaya Asya 
Published: February 2024

Background:
RASFF notifications serve to determine the hazards responsible for food
and feed. In case of determining risks to human health, the information provided to member countries via the rapid alarm system at the same time warned us to take the necessary measures.

Objectives:
In this research, the RASFF portal alerts over the last three years related to aflatoxins
in hazelnut, fig, and peanut products were examined. The impact of image processing technologies on lowering the danger of aflatoxins in shelled hazelnuts and dried figs was also investigated,
as well as Critical Control Points (CCPs) on aflatoxin hazard.

Methods:
The RASFF database was used in the RASFF Window portal and analyzed for aflatoxin
alerts. ISO 22000:2018 was used for hazard and risk analysis for raw hazelnut, peanut, and fig
products. Aflatoxin analyses were performed according to the AOAC 2000/991.31 method. Prior
to and after hazelnut sorting methods, levels of aflatoxin were measured. Besides, aflatoxin contamination in peanuts harvesting in 2023 years from three local producers in Turkey was studied.

Results:
The number of RASFF notifications for hazelnuts, peanuts/groundnuts, dried figs, and
their products for the period of 03/01/2020 to 01/06/2023 were 84, 283 and 173, respectively. As a
result of HACCP implementation, especially for aflatoxin hazard management, optical-laser-manual sorting and aflatoxin detection using UV light stages are accepted as CCPs. When nuts were
sorted using optical and laser systems were detected decreasing total aflatoxin levels. The mean
value of Aflatoxin B1(AFB1) and total aflatoxins were reduced from 7.80±1.08 and 13.56±1.06 to
3.63±0.39 and 7.21±0.71, respectively. 79.16% of all sorted samples were found to comply with
legal limits. Investigated peanut samples for aflatoxin B1 contents were found between 5.63 and
27.75 µg kg-1 in 19.5%.

Conclusion:
The alerts based on aflatoxin contamination above legal limits have been carried on
for nuts and dried figs. The physical sorting methods using optical selection and high-resolution
laser sensor systems aflatoxin-contaminated nuts from healthy nuts applied for in-shell Turkish
nut sorting were able to assess the quality of the batch studied, and the systems were assigned significantly effective to reduce aflatoxin contents. Food business operators in Turkey, which is
among the countries exporting agricultural and food products to the European Union (EU), have
tended to prefer the most advanced technologies. Efficacies of reduction of aflatoxin by different
physical and other (such as imaging, X-ray and acoustic, audio signals and hyperspectral images
of moldy natural nuts etc.) methods will be developed in the near future.
A-RFP: An Adaptive Residue Flexibility Prediction Method Improving Protein-ligand Docking Based on Homologous Proteins
Authors: Lei Chuqi , Fang Senbiao , Li Yaohang , Guo Fei , Li Min 
Published: February 2024

Background:
Computational molecular docking plays an important role in determining
the precise receptor-ligand conformation, which becomes a powerful tool for drug discovery. In the
past 30 years, most computational docking methods have treated the receptor structure as a rigid
body, although flexible docking often yields higher accuracy. The main disadvantage of flexible
docking is its significantly higher computational cost. Due to the fact that different protein pocket
residues exhibit different degrees of flexibility, semi-flexible docking methods, balancing rigid
docking and flexible docking, have demonstrated success in predicting highly accurate conformations
with a relatively low computational cost.

Methods:
In our study, the number of flexible pocket residues was assessed by quantitative analysis,
and a novel adaptive residue flexibility prediction method, named A-RFP, was proposed to improve
the docking performance. Based on the homologous information, a joint strategy is used to predict
the pocket residue flexibility by combining RMSD, the distance between the residue sidechain and
the ligand, and the sidechain orientation. For each receptor-ligand pair, A-RFP provides a docking
conformation with the optimal affinity.

Results:
By analyzing the docking affinities of 3507 target-ligand pairs in 5 different values ranging
from 0 to 10, we found there is a general trend that the larger number of flexible residues inevitably
improves the docking results by using Autodock Vina. However, a certain number of counterexamples
still exist. To validate the effectiveness of A-RFP, the experimental assessment was tested in a
small-scale virtual screening on 5 proteins, which confirmed that A-RFP could enhance the docking
performance. And the flexible-receptor virtual screening on a low-similarity dataset with 85 receptors
validates the accuracy of residue flexibility comprehensive evaluation. Moreover, we studied
three receptors with FDA-approved drugs, which further proved A-RFP can play a suitable role in
ligand discovery.

Conclusion:
Our analysis confirms that the screening performance of the various numbers of flexible
residues varies wildly across receptors. It suggests that a fine-grained docking method would
offset the aforementioned deficiency. Thus, we presented A-RFP, an adaptive pocket residue flexibility
prediction method based on homologous information. Without considering computational resources
and time costs, A-RFP provides the optimal docking result.
Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and
DNA Damage
Authors: Fan Ning , Zhang Lixiu , Wang Zhiping , Ding Hui , Yue Zhongjin 
Published: February 2024

Background:
Bladder cancer is the most common malignant tumor of the urinary system. Nevertheless,
current therapies do not provide satisfactory results. It is imperative that novel strategies should be developed
for treating bladder cancer.

Objective:
To evaluate the effect of a broad-spectrum anti-parasitic agent, Ivermectin, on bladder cancer cells in
vitro and in vivo.

Methods:
CCK-8 and EdU incorporation assays were used to evaluate cell proliferation. Apoptosis was detected
by flow cytometry, TUNEL assay, and western blotting. Flow cytometry and DCFH-DA assay were used to analyze
the reactive oxygen species (ROS) levels. DNA damage was determined by Neutral COMET assay and γ
H2AX expression. Proteins related to apoptosis and DNA damage pathways were determined by WB assay. Xenograft
tumor models in nude mice were used to investigate the anti-cancer effect of Ivermectin in vivo.

Results:
Our study showed that in vitro and in vivo, Ivermectin inhibited the growth of bladder cancer cells. In
addition, Ivermectin could induce apoptosis, ROS production, DNA damage, and activate ATM/P53 pathwayrelated
proteins in bladder cancer cells.

Conclusion:
According to these findings, Ivermectin may be a potential therapeutic candidate against bladder
cancer due to its significant anti-cancer effect.
T Lymphocyte Interferon-gamma Response to Anaplasmataceae-related
Major Surface Proteins and Ankyrin A in Fibromyalgia
Authors: Puri Basant K. , Preyer Rosemarie , Lee Gary S. , Schwarzbach Armin 
Published: February 2024

Background:
The aetiology of fibromyalgia is unknown; its symptoms may be related to
a T-lymphocyte-mediated response to infectious organisms.

Objectives:
First, to test the hypothesis that fibromyalgia is associated with increased interferon
(IFN)-γ-secreting T-lymphocytes after stimulation with Anaplasmataceae-related major surface proteins
(MSPs) and the macromolecular translocation type IV secretion system effector ankyrin repeat
domain-containing protein A (AnkA). Second, to ascertain the relationship in fibromyalgia between
(i) the IFN-γ-secreting T-lymphocyte response to stimulation with Anaplasmataceae-related MSPs
and AnkA, and (ii) co-infection by Borrelia and Yersinia spp., and antinuclear antibodies.

Methods:
Using a case-control design, patients fulfilling the American College of Rheumatology
revised criteria for fibromyalgia, and controls, underwent the following blinded assessments: (i) enzyme-
linked immune absorbent spot (ELISpot) IFN-γ release assay of T-lymphocyte reactivity to
Anaplasmataceae-related MSPs and AnkA; (ii) ELISpot IFN-γ release assays of T-lymphocyte reactivity
to three Borrelia antigens, namely Borrelia burgdorferi full antigen (B31); peptide mix (from
Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii); and Borrelia burgdorferi lymphocyte
function-associated antigen-1; (iii) immunoglobulin (Ig) A assay by enzyme-linked immunosorbent
assay (ELISA) of antibodies to Yersinia spp.; (iv) IgG (ELISA) antibodies to Yersinia
spp.; (v) serum antinuclear antibodies (immunofluorescence).

Results:
The groups were age- and sex-matched. The mean (standard error) value of IFN-γ release
for the fibromyalgia group was 1.52 (0.26), compared with 1.00 (0.22) for the controls. Generalised
linear modelling (p<0.001) of IFN-γ release in the fibromyalgia patients showed significant main
effects of all three indices of Borrelia infection and of antinuclear antibodies.

Conclusion:
Anaplasmataceae may play an aetiological role in fibromyalgia.