bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Chemo‐Hydrodynamical Oscillations in Bimolecular Reactions on Mixing
Authors: Bigaj Adam , Budroni Marcello A. , Rongy Laurence 
Published: January 2025

AbstractSelf‐organizing behaviors have long been studied in complex chemical systems involving a nonlinear chemical feedback (e. g. the Belousov‐Zhabotinsky and Bray‐Liebhafsky reactions). Here we explore the emergence of oscillatory dynamics by coupling simpler chemical processes, in the form of a bimolecular reaction, and natural convection (i. e. flows induced by changes in density and surface tension occurring during the reaction). We study and classify different possible scenarios based on the interplay between chemically‐driven Marangoni‐ (surface tension induced) and buoyancy‐driven (density induced) flows. This coupling can either be antagonistic, whereby both generated flows are opposing (e. g. a reaction increasing the surface tension and decreasing the density), or cooperative if both flows act in the same direction (e. g. a reaction increasing both surface tension and density). We further investigate the impact of these oscillations on the mixing and reaction rate.
I’m Afraid HAL Can’t Do That: Your Smart Home Is Not That Kind of Existential Threat
Authors: Zebrowski Robin L. 
Published: January 2025

Abstract
This chapter starts at the cliché of the smart home that has gone rogue and introduces the question of whether these integrated, distributed systems can have ethical frameworks like human ethics that could prevent the science fictional trope of the evil, sentient house. I argue that such smart systems are not a threat on their own, because these kinds of integrated, distributed systems are not the kind of things that could be conscious, a precondition for having ethics like ours (and ethics like ours enable the possibility of being the kinds of things that could be evil). To make these arguments, I look to the history of AI/artificial consciousness and 4e cognition, concluding with the idea that our human ethics as designers and consumers of these systems is the real ethical concern with smart life systems.
Conclusions
Authors: Hollnaicher Simon 
Published: January 2025

Abstract
This chapter summarizes the findings of the book, offering a concise version of the answer the book gives to the “value problem in assessing feasibility”. It provides an overview of the book's argument, outlining how each chapter contributes to addressing this issue. The chapter also reflects on the book’s limitations, acknowledging the diversity within the field of integrated modeling and the normative standpoint adopted in the discussion. The chapter situates the book’s contribution within existing debates, emphasizing how it advances understanding of feasibility assessments in value-laden contexts. Finally, it cautions that despite their inherent value-dependence, Integrated Assessment Models convey a clear and robust call to action—the current trajectory of emissions must be decisively reversed to achieve sustainable futures.
A window into intracellular events in myositis through subcellular proteomics
Authors: Peterson Jennifer M. , Leclair Valérie , Oyebode Olumide E. , Herzallah Dema M. , Nestor-Kalinoski Andrea L. , Morais Jose , Zahedi René P. , Alamr Mazen , Di Battista John A. , Hudson Marie 
Published: January 2025

Abstract

Objective and design
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of inflammatory muscle disorders of unknown etiology. It is postulated that mitochondrial dysfunction and protein aggregation in skeletal muscle contribute to myofiber degeneration. However, molecular pathways that lead to protein aggregation in skeletal muscle are not well defined.

Subjects
Here we have isolated membrane-bound organelles (e.g., nuclei, mitochondria, sarcoplasmic/endoplasmic reticulum, Golgi apparatus, and plasma membrane) from muscle biopsies of normal (n = 3) and muscle disease patients (n = 11). Of the myopathy group, 10 patients displayed mitochondrial abnormalities (IIM (n = 9); mitochondrial myopathy (n = 1)), and one IIM patient did not show mitochondrial abnormalities (polymyositis).

Methods
Global proteomic analysis was performed using an Orbitrap Fusion mass spectrometer. Upon unsupervised clustering, normal and mitochondrial myopathy muscle samples clustered separately from IIM samples.

Results
We have confirmed previously known protein alterations in IIM and identified several new ones. For example, we found differential expression of (i) nuclear proteins that control cell division, transcription, RNA regulation, and stability, (ii) ER and Golgi proteins involved in protein folding, degradation, and protein trafficking in the cytosol, and (iii) mitochondrial proteins involved in energy production/metabolism and alterations in cytoskeletal and contractile machinery of the muscle.

Conclusions
Our data demonstrates that molecular alterations are not limited to protein aggregations in the cytosol (inclusions) and occur in nuclear, mitochondrial, and membrane compartments of IIM skeletal muscle.
D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala
Authors: Sabnis Siddhesh S. , S. Narasimhan Kishore Kumar , Chettiar Poojashree B. , Shelkar Gajanan P. , Dravid Shashank M. 
Published: January 2025

Abstract
Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission in the nervous system. In addition to NMDA receptor co-agonists, D-serine is a ligand for glutamate delta receptors (GluDs) and interacts with the ligand-binding domain with low affinity. However, D-serine binding does not lead to typical ion channel currents in GluD1 or GluD2 but may contribute to synaptic plasticity. In the developing brain, D-serine binding to GluD2 facilitates long-term depression at parallel fiber-Purkinje cell synapses. However, the influence of D-serine on GluD1's interaction with its amino terminal domain synaptogenic ligand Cbln1 and its subsequent impact on synaptic function and behavior remains unexplored. Here, we found that D-serine inhibited the interaction between Cbln1 and GluD1 in an in vitro cell-binding assay. This effect was concentration-dependent, with an IC50 value of ~ 300 µM. Furthermore, in ex vivo central amygdala (CeA) slices application of recombinant Cbln1 (rCbln1), consistent with its synaptogenic property, produced a robust increase in excitatory neurotransmission and GluD1 expression. This effect of rCbln1 was partially blocked by pre-treatment with D-serine. Finally, in behavioral experiments, we observed that the pro-nociceptive effect of intra-CeA injection of rCbln1 was inhibited by pre-treatment with D-serine. In addition, the antinociceptive effect of intra-CeA rCbln1 injection in an inflammatory pain model was blocked by D-serine. Overall, these results demonstrated that D-serine binding to GluD1 reduces its interaction with Cbln1, which may be relevant to synaptic plasticity and behavior.

Graphical Abstract
Überlastungssyndrome am Kniegelenk
Authors: Benefelds Marc , Mayr Raul , Hackl Wolfgang , Schneider Friedemann 
Published: January 2025

Zusammenfassung
Überlastungssyndrome am Kniegelenk sind eines der häufigsten Beschwerdebilder im Sport überhaupt. Es kann aber auch den Nichtsporttreibenden betreffen. In der Regel ist die Ursache muskulär bedingt, kann ihren Ursprung aber auch vom Knorpel oder der Gelenkkapsel haben. Zudem gilt es, andere Krankheitsbilder abzugrenzen. Zur Erstellung einer korrekten Diagnose ist eine detaillierte Untersuchung unumgänglich. Die alleinige Abklärung nur mittels Magnetresonanztomographie (MRT) reicht oft nicht aus, wenn der klinische Befund ungenügend erhoben wurde. In diesem Beitrag werden die wichtigsten Erkrankungen sowie deren Entstehung und Therapie dargestellt.
Efficacy of 100-U Onabotulinumtoxin A Treatment in Female Idiopathic Overactive Bladder—A Prospective Follow-Up Study
Authors: Nurkkala Mona , Salo Heini , Piltonen Terhi , Sova Henri , Rossi Henna-Riikka 
Published: January 2025

Abstract

Introduction and Hypothesis
Overactive bladder (OAB) affects 11–17% of the female population. First-line treatment with lifestyle modifications and second-line therapy with medications are often limited by inadequate efficacy or pharmacological side effects. This study was aimed at assessing the effect of 100 U onabotulinumtoxin A treatment on idiopathic OAB (iOAB) as a second-line treatment.

Methods
This prospective follow-up study involved 94 women who received onabotulinumtoxin A treatment at a dose of 100 U as a second-line treatment for iOAB at the Department of Obstetrics and Gynecology, Oulu University Hospital, Finland, between May 2018 and December 2023. The impact of the treatment on iOAB symptoms was evaluated 3 months after administration using self-reported symptoms and the following internationally validated questionnaires: Visual Analogue Scale (VAS), Incontinence Impact Questionnaire (IIQ-7), and Urogenital Distress Inventory (UDI-6). Postoperative complications were assessed.

Results
The follow-up data were obtained from 74 (78%) patients, of whom 66 (95.7%) reported a good outcome and 3 (4.3%) reported a poor outcome. Incontinence episodes, the number of incontinence pads needed, and daily micturitions were significantly reduced. For all questionnaires, the total scores decreased significantly after the treatment (VAS 8.27 ± 1.78 vs 3.50 ± 3.08, p < 0.001; IIQ-7 72.14 ± 20.55 vs 28.73 ± 29.40, p < 0.001; UDI-6 55.01 ± 18.86 vs 29.66 ± 22.03, p < 0.001). Postoperative urinary tract infection occurred in 9 patients (9.6%), whereas urinary retention occurred in 6 patients (6.4%).

Conclusions
Onabotulinumtoxin A (100 U) demonstrates good effectiveness in the second-line treatment of female iOAB.
Museomic analyses clarify species diversity in the icefish genus Channichthys
Authors: Garmann-Aarhus Benedicte , Nikolaeva Ekaterina , Desvignes Thomas , Straube Nicolas , Matschiner Michael 
Published: January 2025

Abstract
The rapid diversification of notothenioid fishes in Antarctic waters is a prime example of the process of adaptive radiation. Within around 10 million years, Antarctic notothenioids have diversified into over 100 species with a broad range of lifestyles and ecological adaptations. However, the exact number of species within this radiation has long been unclear. Particularly challenging is the taxonomy of the genus Channichthys, for which between one and nine species have been recognized by different authors. The putative species of this genus are known from a limited number of specimens, of which most were sampled decades ago. Here, we investigated the mitochondrial genomes of museum specimens representing the four species Unicorn Icefish (C. rhinoceratus), Red Icefish (C. rugosus), Sailfish Pike (C. velifer), and Charcoal Icefish (C. panticapaei), complemented by morphological analyses. All analyzed specimens were collected in the 1960s and 1970s and fixed in formaldehyde, and their DNA has been heavily degraded. Applying ancient-DNA protocols for DNA extraction and single-stranded library preparation, we were able to obtain sufficient endogenous DNA to reconstruct the mitochondrial genomes of one specimen per species. These mitochondrial genome sequences were nearly identical for the three specimens assigned to Unicorn Icefish, Red Icefish, and Sailfish Pike, while greater divergence was observed for the Charcoal Icefish specimens. We discuss possible explanations of the contrast between these molecular results and the recognizable morphological variation found among the four species, and recommend that at least the Charcoal Icefish be included in the list of valid notothenioid species.
A practical work around for breast density distribution discrepancies between mammographic images from different vendors
Authors: Wagner Tobias , Cockmartin Lesley , Wang Yao-Kuan , Marshall Nicholas , Bosmans Hilde 
Published: January 2025

Abstract

Objectives
Investigate the impact of mammography device grouped by vendor on volumetric breast density and propose a method that mitigates biases when determining the proportion of high-density women.

Materials and methods
Density grade class and volumetric breast density distributions were obtained from mammographic images from three different vendor devices in different centers using breast density evaluation software in a retrospective study. Density distributions were compared across devices with a Mann–Whitney U test and breast density thresholds corresponding to distribution percentiles calculated. A method of matching density percentiles is proposed to determine women at potentially high risk while mitigating possible bias due to the device used for screening.

Results
2083 (mean age 59 ± 5.4), 531 (mean age 58.8 ± 5.7) and 244 (mean age 60.7 ± 6.0) screened women were evaluated on three vendor devices, respectively. Both the density grade distribution and the volumetric breast density were different between Vendor 1 and Vendor 2 data (p < 0.001) and between Vendor 1 and Vendor 3 data (p < 0.001). Between Vendor 2 and Vendor 3, no significant difference was observed (p = 0.67 for density grade, p = 0.29 for volumetric density). To recruit the top 10% of women with extremely dense breasts required respective density thresholds of 16.1%, 13.6% and 13.8% for the three vendor devices.

Conclusion
Density grade class and volumetric breast density distributions differ between devices grouped by vendor and can result in statistically different breast density distributions. Percentile-dependent density thresholds can ensure unbiased selection of high-risk women.

Key Points

Question

Does the use of x-ray systems from different vendors influence breast density evaluation and the resulting selection of high-risk women during breast cancer screening?

Findings

Statistically significant differences were observed between breast density distributions of different vendors; a method of matching via percentiles is proposed to prevent biased density evaluations.

Clinical relevance

Measured breast density distributions differed between X-ray devices. A workaround is proposed that determines density thresholds corresponding to a specified population, allowing the same proportion of women to be selected with a density algorithm.

Graphical Abstract
Frequency of CMV testing during pregnancy-a retrospective study
Authors: Hadjiiona A. , Michaelides I. , Kummer P. , Kappelmeyer M. , Koeninger A. , Reuschel E. 
Published: January 2025

Abstract

Purpose
The cytomegalovirus (CMV) belongs to the family of human Herpesviridae and is distributed worldwide. It is the most common cause of viral congenital infections and can have serious consequences for the health of the fetus in the event of a vertical transmission. This study, taking place for the first time in Upper Palatinate, Bavaria, aims to evaluate the frequency of CMV testing among pregnant women in our region in Germany, which for some individuals can be an expensive individual health service.

Methods
Retrospectively, 1000 pregnant patients aged 17–45 years who were treated in the University Clinic St. Hedwig, Regensburg, Germany, were included in the study. It was investigated whether a CMV test was carried out during pregnancy and which results were obtained.

Results
597 patients (59.7%) had not received a CMV test during pregnancy. Among the 403 (40.3%) patients who had undergone CMV testing, seropositivity was detected in 143 (35.5%). 257 patients (63.8%) were seronegative, while 3 (0.74%) had a primary infection.

Conclusion
Although CMV is the most common pathogen of viral congenital infections and can severely impair the health of affected newborns, CMV diagnostics during pregnancy is still not an integral part of the maternity guidelines in Germany, but rather an individual healthcare service, meaning that the patients undergoing the test must bear the full cost. An antiviral treatment with valacyclovir has shown good preventive and therapeutic success, but unfortunately, there is currently no vaccination available to prevent vertical transmission, which is why early diagnosis and hygiene measures are the most important means of preventing seroconversion of the mother and possible infection of the fetus.
Risk factors for surgery in children with ureteropelvic junction obstruction due to antenatally detected ınfantil hydronephrosis
Authors: Aytac Mehmet Baha , Ergul Sule Ayas , Dogan Kenan , Malkoc Neslihan Dincer , Ozgur Merve Aktas , Ozkurkcugil Cuneyd , Teke Kerem , Bayrak Busra Yaprak , Ekinci Zelal , Bek Kenan 
Published: January 2025

Abstract

Background
Although the majority of cases with antenatally detected hydronephrosis (ANH) resolve during postnatal period; patients should be monitored for the risk of developing ureteropelvic junction obstruction (UPJO) which requires surgical intervention. We aimed to define independent risk factors for operation in whom diagnosis of UPJO was precisely proven with histopathological evidence.

Methods
Medical files of 155 children (186 renal units) with anteroposterior pelvic diameter (APPD) ≥ 7 mm or ≥ 1SFU (Society of Fetal Urology) grade of pelvicalyceal dilatation were retrospectively investigated. Patients who underwent pyeloplasty and whose pathological examinations of resected ureteral samples confirmed obstruction, were compared to non-interventional group in terms of demographics, serum creatinine, APPD, SFU grade, cortical thickness and diuretic renogram. Multiple regression models were used to predict independent risk factors for pyeloplasty.

Results
155 patients (186 renal units) were recruited for the study. Pyeloplasty was performed in 50(32.2%) patients. Increased APPD, T1/2 and Tmax values with low parenchymal thickness and DRF were demonstrated in operated patients compared to those who did not. Significant decrease in APPD and T1/2 values and also significant improvement in parenchymal thickness were observed in conservatively managed group. Multivariate analysis revealed high APPD measurements and time activity curve patterns to be associated with significantly increased likelihood of surgical intervention.

Conclusions
There is still an ongoing debate on which screening method should be used for the accurate diagnosis of UPJO or the indications for surgical intervention. Baseline APPD and diuretic renogram curve were found to be significant in predicting surgery for UPJO.
Effect of storage conditions on the brownstock washing and oxygen delignification of kraft pulps
Authors: Senthilkumar Eashwara Raju , Sjöström Jenny , Henriksson Gunnar , Vikström Tomas , Sevastyanova Olena 
Published: January 2025

Abstract
A long-term goal of the pulping industry is to optimize process parameters for efficiently removing degraded and soluble lignin during the fiber line processes such as kraft pulping, brownstock washing, and bleaching. This study investigates how pulp storage affects the efficiency of brownstock washing and oxygen delignification. Three pulp groups were rinsed with warm and cold water at 40 °C and 5 °C, respectively, and then stored under varying conditions (1 day, 1 week at temperatures of 5 °C and 60 °C. Our findings indicate that after one week of storage at 60 °C, more lignin was extracted, highlighting the influence of storage temperature and time on Kappa reduction (lignin removal) during storage. Additionally, larger lignin fragments were removed with increased storage temperature and time, suggesting that degraded lignin molecules trapped within the fibers can leach out during storage and be subsequently removed in washing. The different storage conditions had only a slight effect on oxygen delignification performance. We conclude that storage conditions, particularly temperature and time, significantly impact lignin removal efficiency and can enhance the pulp washing process. This study also provides valuable insights into lignin mass transfer during storage, offering guidance for industrial applications. The study also revealed that pulp quality after oxygen delignification is influenced by pH and lignin agglomeration and retention in the fibers during preceding washing and storage operations, emphasizing the need for careful control of the latter conditions to minimize cellulose degradation.
Approximating exponentials of commutators by optimized product formulas
Authors: Casas F. , Escorihuela-Tomàs A. , Moreno Casares P. A. 
Published: January 2025

Abstract
Trotter product formulas constitute a cornerstone quantum Hamiltonian simulation technique. However, the efficient implementation of Hamiltonian evolution of nested commutators remains an under explored area. In this work, we construct optimized product formulas of orders 3–6 approximating the exponential of a commutator of two arbitrary operators in terms of the exponentials of the operators involved. The new schemes require a reduced number of exponentials and thus provide more efficient approximations than other previously published alternatives. They can also be used as basic methods in recursive procedures to increase the order of approximation. We expect this research will improve the efficiency of quantum control protocols, as well as quantum algorithms such as the Zassenhaus-based product formula, Magnus operator-based time-dependent simulation, and product formula schemes with modified potentials.
Quantitative methodology for poly (butylene adipate-co-terephthalate) (PBAT) microplastic detection in soil and compost
Authors: Hernandez-Charpak Yvan D. , Kansara Harshal J. , Lodge Jeffrey S. , Eddingsaas Nathan C. , Lewis Christopher L. , Trabold Thomas A. , Diaz Carlos A. 
Published: January 2025

Abstract
With the increasing use of biodegradable plastics in agriculture and food packaging, it has become increasingly important to assess the effects of their fragmentation and mineralization in the environment (i.e., soil, compost). PBAT is a biodegradable polyester widely used in biodegradable mulch films that are intended to fragment and mineralize in soil. To study these effects, novel methodologies are needed to quantify PBAT microplastics in these diverse environments. This work seeks to answer whether gas chromatography mass spectrometry (GCMS) can be used as a tool to assess PBAT microplastics in soil. A method was developed that allows PBAT soil extraction by ultrasonication and GCMS quantification after a fatty acid methyl ester derivatization. To validate the method, an industrial compost degradation experiment was carried out to evidence the weight loss of PBAT film and quantify the micro- and nano-plastic generated from them. The presented method improved the existing resolution by, at least, one order of magnitude compared to reported methods. In conclusion, a novel, simple, affordable, and reproducible methodology for PBAT microplastic detection was developed improving the limits of detection and quantification. The method was tested on an industrial compost experiment, demonstrating the ability to trace the totality of the plastic over time, evidencing that PBAT is consumed in the industrial compost environment.
Validation of a contour diagram-based model for monopile cyclic design in sand and clay
Authors: Lapastoure Louis-Marin , Jalilvand Soroosh , Igoe David 
Published: January 2025

Abstract
Monopiles are the most popular type of foundation for offshore wind turbines. Although capturing the effects of cyclic loading is critical to the design of monopiles, there is no recommended approach in the main design standards and no consensus in the literature as to how this can be achieved. Hence, this paper presents the step-by-step methodology and validation of a new cyclic model in sand and clay. The model consists of the degradation of monotonic soil reaction curves based on soil cyclic contour diagrams. The model is found to provide a very satisfactory match with the PISA field tests in Dunkirk dense marine sand and Cowden stiff glacial till.