bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal for a framework for the use of secondary data in health education
Authors: Figueiredo Francisco Winter dos Santos , Silva Bhárbara Karolline Rodrigues , Neto Luiz Sinésio Silva , Quaresma Fernando Rodrigues Peixoto , Maciel Erika da Silva 
Published: November 2023

Abstract

Objective
To describe the major sources of secondary data in healthcare and develop a framework for using these data in teaching.
Methods
A narrative literature search was conducted in PubMed, Scopus and the Virtual Health Library using descriptors related to teaching, secondary data and health in Portuguese, English and Spanish. In addition, through the meeting of experts and based on the articles found in the review, a unified framework of these data in teaching is created.
Results
79 studies were found, of which 14 were included after meeting the eligibility criteria. The main databases found were from the Ministry of Education, the SUS Department of Information Technology, and other sources (Institute of Health Metrics and Evaluation and Institute of Applied Economic Research) were included after a meeting with experts. The developed framework consists of three phases and 11 elements, including planning, searching and extracting data, adapting for teaching, and incorporating data for health teaching.
Conclusion
There are few data sources that can be used for health education, but those proposed are used in this framework, it is possible to transform the data into knowledge that can be transferred to teaching, taking into account teachers' knowledge of indicators, Technologies and innovations are taken into account in teaching.
Role of Fibroblast Growth Factor-23 as an Early Marker of Metabolic Bone Disease of Prematurity
Authors: Llorente-Pelayo Sandra , Docio Pablo , Arriola Silvia , Lavín-Gómez Bernardo A. , García-Unzueta María T. , Ballesteros María Ángeles , Cabero-Pérez M Jesús , González-Lamuño Domingo 
Published: November 2023

Abstract
Purpose: Metabolic bone disease of prematurity (MBDP) remains a significant cause of morbidity in extremely premature newborns. In high-risk patients, suspected diagnosis and subsequent treatment modifications, with limitations in terms of sensitivity and specificity, rely on low phosphorus levels and/or high levels of alkaline phosphatase (ALP). We investigatedthe potential of fibroblast growth factor-23 (FGF23) as an early marker for MBDP when measured at 3-4 weeks of life in at-risk patients.
Methods: This single-center prospective observational noninterventional study includedpreterm newborns of both sexes, with a gestational age of less than 32 weeks and/or a birth weight of less than 1500 grams. In the standard biochemical screening for MBDP performed between 3 and 4 weeks of life within a nutritional profile, the determination of FGF23 was included along with other clinical and metabolic studies.
Results: In astudy involving 25 at-risk premature newborns, 20% (n=5) were diagnosed with MBDP. Three of these patients (60%) were identified as high-risk based on biochemical evaluation at 3-4 weeks of age, while the other two patients (40%) were diagnosed in subsequent weeks. However, in all 5 patients, measurement of FGF23 levels would allow for early identification and optimization of treatment before other markers become altered. Low levels of FGF23 at 3-4 weeks, even with normal phosphorus and ALP levels, indicatethe need for modifications in nutritional supplementation.
Conclusions: MBDP remains a significant concern in extremely premature newborns. Current diagnostic techniques are limited, necessitating reliance on biochemical markers. Early detection of low FGF23 levels allows for timely treatment interventions, potentially preventing demineralization.
Multiline Orthogonal Scanning Temporal Focusing (mosTF) Microscopy for Scattering Reduction in High-speed in vivo Brain Imaging
Authors: Xue Yi , Boivin Josiah R. , Wadduwage Dushan N. , Park Jong Kang , Nedivi Elly , So Peter T. C. 
Published: November 2023

Abstract
Temporal focusing two-photon microscopy enables high resolution imaging of fine structures in vivo over a large volume. A limitation of temporal focusing is that signal-to-background ratio and resolution degrade rapidly with increasing imaging depth. This degradation originates from the scattered emission photons are widely distributed resulting in a strong background. We have developed Multiline Orthogonal Scanning Temporal Focusing (mosTF) microscopy that overcomes this problem. mosTF captures a sequence of images at each scan location of the excitation line, followed by a reconstruction algorithm reassigns scattered photons back to the correct scan position. We demonstrate mosTF by acquiring mice neuronal images in vivo. Our results show remarkably improvements with mosTF for in vivo brain imaging while maintaining its speed advantage.
Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer
Authors: Liu Yan , Wang Junli , Guo Jimin , Zhang Qianyi , Wang Shuqing , Hu Fen , Wu Jinghua , Zhao Yating , Zhang Jinghua , Yu Yuan , Li Yufeng , Zhang Xiaojun 
Published: November 2023

Abstract
BAZ2A, an epigenetic regulatory factor that affects ribosomal RNA transcription, has been shown to be highly expressed in several cancers and promotes tumor cell migration. This study explored the expression and mechanism of BAZ2A in tumorigenesis at the pan-cancer level. The Cancer Genome Atlas, Gene Expression Omnibus databases and TIMER2.0, cBioPortal and other tools were used to analyze the level of expression of BAZ2A in various tumor tissues and to examine the relationship between BAZ2A and survival, prognosis, mutation and immune invasion. In vitro experiments were performed to assess the function of BAZ2A in cancer cells. Using combined transcriptome and proteome analysis, we examined the possible mechanism of BAZ2A in tumors. BAZ2A exhibited high expression levels in multiple tumor tissues and displayed a significant association with cancer patient prognosis. The main type of BAZ2A genetic variation in cancer is gene mutation. Downregulation of BAZ2A inhibited proliferation, migration, and invasion and promoted apoptosis in LM6 liver cancer cells. The mechanism of BAZ2A in cancer development may involve lipid metabolism. These results help expand our understanding of BAZ2A in tumorigenesis and development and suggest BAZ2A may serve as a prognostic and diagnostic factor in several cancers.
ParseGBIF: An R package for parsing species occurrence records into unique collection events
Authors: de Melo Pablo Hendrigo Alves , Bystriakova Nadia , Lucas Eve , Monro Alexandre 
Published: November 2023

Abstract
Biodiversity data aggregators, such as Global Biodiversity Information Facility (GBIF) suffer from inflation of the number of occurrence records when data from different databases are merged but not fully reconciled. The ParseGBIF workflow is designed to parse duplicate GBIF species occurrence records into unique collection events (gatherings) and to optimise the quality of the spatial data associated with them. ParseGBIF provides tools to verify and standardize species scientific names according to the World Checklist of Vascular Plants taxonomic backbone, and to parse duplicate records into unique ‘collection events’, in the process compiling the most informative spatial data, where more than one duplicate is available, and providing crude estimates of taxonomic and spatial data quality. When GBIF occurrence records for a medium-sized vascular plant family, the Myrtaceae, were processed by ParseGBIF, the average number of records useful for spatial analysis increased by 180%. ParseGBIF could therefore be valuable in the evaluation of species’ occurrences at the national scale in support for national biodiversity plans, identification of plant areas important for biodiversity, sample bias estimation to inform future sampling efforts, and to forecast species range shifts in response to global climate change.
Identification and Validation of an Anoikis-Related Gene Signature to Predict Prognosis in Colorectal Cancer
Authors: Shu Qiuxia , Yu Qing , Kang Lili , Qin Cao , He Jiangyi , Gong Yuzhu 
Published: November 2023

Abstract
Purpose
Colorectal cancer (CRC) is highly aggressive, with advanced tumors resulting in poor prognosis. Anoikis is a type of programmed cell death that is important in malignant solid tumor occurrence and progression. However, research on the role of anoikis in CRC and its prognosis is lacking.
Methods
Using patient data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA), anoikis related genes (ARGs) were identified. Gene Ontology (GO) and Gene Set Enrichment Analysis (GSEA) were performed to explore ARG-related biological pathways. We used least absolute shrinkage and selection operator (LASSO) regression analysis to construct a prognostic model, and the LASSO-derived median risk score could divide the cancer group into high- and low-risk groups. The prognostic value of ARGs was analyzed using multivariate COX regression and receiver operating characteristic curves (ROCs). We used decision curve analysis (DCA) to evaluate the clinical utility of the constructed prognostic model.
Results
We identified 21 differentially expressed genes, and the GO and GSEA analyses showed that genes in the dataset TCGA-COADREAD were significantly enriched in the WNT signaling pathway and pluripotency, negative regulation of NOTCH4 signaling, PI3K-AKT signaling pathway, and L1CAM interactions. Eight genes were verified in the GSE17536 and TCGA-COADREAD datasets (BRCA2, CXCL8, ITGA2, KLF4, PLAU, SOX9, TPM1, VSNL1). DCA indicated that the model's 5-year predictive effect was better than that at 1 and 3 years.
Conclusions
We demonstrated the value of ARGs to assess CRC prognosis, potentially providing new insights into CRC survival prediction and therapeutic targets.
Remote Video-Delivered Suturing Education with Smartphones: A Non-Inferiority Randomized Controlled Trial
Authors: How Nathan , Ren Kevin , Qiu Yuan , Hamann Karyssa , Leveille Cameron F. , Davidson Alexandra , Eqbal Adam , Sardiwalla Yaeesh , Korostensky Michael , Duchesnay Isabelle , McKechnie Tyler , Lee Elizabeth , Hopkins Erik , Logie Kathleen , Yang Ilun 
Published: November 2023

Abstract
Objective: To measure remote feedback's educational benefit, assess its perceived feasibility and utility, and demonstrate implementation of a practical and cost-effective model.
Design: Medical students were randomized to receive live video- or recorded video-delivered feedback on suturing skills. A non-randomized control group received in-person feedback. Pre- and post-feedback recordings of suturing were evaluated by blinded assessors to determine improvement using the University of Bergen suturing skills assessment tool (UBAT) and Objective Structured Assessment of Technical Skills (OSATS). Study arms were compared to the control arm in a non-inferiority analysis. Participants and feedback providers completed questionnaires regarding feasibility and utility of their feedback modality.
Participants: Fifty-four first- and second-year medical student participants and 11 surgical resident feedback providers McMaster University.
Results: UBAT score change was 40.5 in the remote live video feedback group, 8.7 in the remote recorded video feedback group, and 18.0 in the in-person feedback group with no significant difference between groups (p=0.619). However, 95% confidence intervals did not exclude a non-inferiority threshold for either video-based experimental arm. Similar findings were demonstrated using the OSATS tool. Questionnaire responses found that participants and feedback providers both rated video-delivered feedback as feasible and useful.
Conclusions: There was no significant difference in learner improvement between live or recorded video-delivered feedback and in-person feedback, but non-inferiority was not established. We have demonstrated subjective feasibility and utility of a highly-accessible and affordable model of remote video-delivered feedback in technical skills acquisition.
Assessment of the Quality of Online Patient-Oriented Information on Robotic Colorectal Surgery
Authors: Amaefule-Orie Grace , Ezeme Constantine , Yeung Trevor 
Published: November 2023

Abstract
INTRODUCTION
With advances in modern medicine, there is a constant need for accurate and up-to-date readily available information online to ensure patients are well-equipped for informed decision making.
AIM
This study sets out to analyze websites that provide patient-centered information on robotic colorectal surgery.
METHOD
Three search engines (Google, Yahoo and Firefox) were used with search terms ‘robotic colorectal surgery’ and the first twenty results on each platform assessed. After screening sites using predetermined criteria, further analysis was performed with the DISCERN questionnaire and Cohen Kappa analysis.
RESULTS
Out of the 60 websites identified from the initial search, only 14 websites contained patient information on robotic colorectal surgery. Of these, only three (21%) sites had been updated in the past year and one site was last updated ten years ago. Ten (71%) websites were affiliated with hospitals and the majority (12, 86%) were based in the United States of America (USA). Approximately half of the websites explored alternative surgical techniques, only three (21%) discussed the risks, a similar number had details on post-operative experience, and none mentioned cost implications, ongoing research or the waiting list involved. Overall, no website had a perfect score of 5 to be classified as good or excellent. There was at least a fair level of agreement (reliability score of >0.2) in twelve DISCERN criteria (80%), four of which were statistically significant.
CONCLUSION
Despite the huge volume of generic information on colorectal surgery, there is still a paucity of comprehensive patient-centered information on robotics as a modality of treatment.
CORRESPONDENCE: Grace Oluchi Amaefule-Orie M.B.B.S., MPH. Email oluchyorie@yahoo.com
Machine Learning-Driven Prognostic Analysis of Cuproptosis and Disulfidptosis-related lncRNAs in Clear Cell Renal Cell Carcinoma: A Step Towards Precision Oncology
Authors: Chen Ronghui , Wu Jun , Che Yinwei , Jiao Yuzhuo , Sun Huashan , Zhao Yinuo , Chen Pingping , Meng Lingxin , Zhao Tao 
Published: November 2023

Abstract
Background
Clear cell renal cell carcinoma (ccRCC), the most prevalent type of kidney malignancy, is noted for its high fatality rate, underscoring the imperative for reliable diagnostic and prognostic indicators. The mechanisms of cell death, cuproptosis and disulfidptosis, recently identified, along with the variable expression of associated genes and long non-coding RNAs (lncRNAs), have been linked to the progression of cancer and resistance to treatment. The objective of this research is to delineate the functions of lncRNAs associated with cuproptosis and disulfidptosis (CDRLRs) in ccRCC, thereby enhancing the precision of prognostic evaluations and contributing to the development of targeted therapeutic approaches.
Methods
We applied the least absolute shrinkage and selection operator (LASSO) regression analysis to construct a prognostic signature from a set of CDRLRs. The data from The Cancer Genome Atlas (TCGA) was segmented into high and low-risk groups based on median risk scores from the signature, to investigate their prognostic disparities.
Results
The derived signature, which includes four CDRLRs—ACVR2B-AS1, AC095055.1, AL161782.1, and MANEA-DT—was confirmed to be predictive for ccRCC patient outcomes, as evidenced by receiver operating characteristic (ROC) curves and Kaplan-Meier (K-M) survival analysis. The prognostic model enabled the graphical prediction of 1-, 3-, and 5-year survival rates for ccRCC patients, with calibration plots affirming the concordance between anticipated and observed survival rates. Additionally, the study assessed tumor mutation burden (TMB) and the immune microenvironment (TME) using oncoPredict and Immunophenoscore (IPS) algorithms, uncovering that patients in the high-risk group presented with increased TMB and distinctive TME profiles, which may influence their response to targeted and immune therapies. Notably, marked differences in the sensitivity to anticancer drugs were observed between the risk groups.
Conclusion
This investigation introduces a prognostic signature comprising cuproptosis and disulfidptosis-associated lncRNAs as a viable biomarker for ccRCC. Beyond enhancing prognostic accuracy, this signature holds the promise for steering personalized treatments, thereby advancing precision oncology for ccRCC. However, it is imperative to pursue further clinical validation to adopt these insights into clinical practice.
Fiber morphological characteristics of bamboo Ferrocabamus strictus culms from different geographical distribution regions
Authors: Zheng Xiaofeng , Xu Rui , Zhou Ziteng , Wang Jiamin , Zhan Hui , Wang Changming 
Published: November 2023

Abstract

The fiber index including fiber length, width, wall thickness and lumen diameter of Ferrocalamus strictus culms (1, 2, and ≥ 3 years) from Jinping, Mojiang and Lvchun counties of Yunnan Province was determined and the elemental content of the soil was also determined to analyze the influence of the culm age and height and soil content on the fiber characteristics. The average relative fiber index measured for F. strictus culms were fiber length (1.30 mm), width (21.57 µm), slenderness ratio (60.79 µm), wall thickness (4.21 µm), lumen diameter (7.22 µm), and runkel ratio (1.22 µm), which belonged to the range of middle and long fibers. The fiber length increased with the culm age. The proportion of long fiber increased while short fibers decreased along with culm maturing. The fiber morphology did not show a specific trend with the culm height. Fiber length reached the maximum in the bottom portions of the culms. There is a correlation between fiber morphology and soil elements, the content of organic matter, total potassium, total sulfur, total aluminum, total zinc, total iron, total boron, alkali-hydrolyzed nitrogen amd available silicon in the soil affects fiber morphology. The content of organic matter, total boron, available potassium and alkali-hydrolyzed nitrogen in the soil from Mojiang County was largest. Comparatively, the culm fiber in Mojiang County had the best fiber index performance for utilization, since the greatest proportion of medium and long fibers and the optimal distribution of fiber length frequency was obtained from the culms in Mojiang County. This study can provide a theoretical basis for large-scale bamboo forest cultivation and the development and utilization of bamboo culm fiber.
Aesthetic Chills Mitigate Maladaptive Cognition In Depression
Authors: Schoeller Felix , Jain Abhinandan , Adrien Vladimir , Maes Pattie , Reggente Nicco 
Published: November 2023

Abstract
Background
Depression is a major global health challenge, affecting over 300 million people worldwide. Current pharmacological and psychotherapeutic interventions have limited efficacy, underscoring the need for novel approaches. Emerging evidence suggests that peak emotional experiences characterized by awe, transcendence, and meaning hold promise for rapidly shifting maladaptive cognitive patterns in depression. Aesthetic chills, a peak positive emotion characterized by physical sensations such as shivers and goosebumps, may influence reward-related neural pathways and hold promise for modifying core maladaptive beliefs rooted in early adverse experiences.
Methods
We enrolled 96 patients diagnosed with major depressive disorder. A validated database of multimedia known to elicit chills responses (ChillsDB) was used for stimulus presentation. Participants' emotional responses were assessed using the Emotional Breakthrough Inventory (EBI), while shifts in self-schema were measured via the Young Schema Questionnaire (YSQ).
Results
The study found that chill-inducing stimuli have the potential to positively influence the core schema of individuals with depression, impacting areas of self-related beliefs. The associated phenomenology triggered by chills appears to share similarities with the altered states of consciousness induced by psychedelic substances like psilocybin.
Conclusions
These preliminary results suggest that the biological processes involved in aesthetic chills could be harnessed as a non-pharmacological intervention for depression. However, further investigation is necessary to comprehensively understand the neurophysiological responses to chills and to evaluate the practicality, effectiveness, and safety of utilizing aesthetic chills as a preventive measure in mental health care.
Chronic iodine intake excess damages the structure of articular cartilage and epiphyseal growth plate
Authors: Zhang Ying , Zhao Xin , Shan Le , Liu Miao , Zhang Zixuan , Wang Zeji , Zhang Xinbao , Meng Haohao , Song Yan , Zhang Wanqi , Sang Zhongna 
Published: November 2023

Abstract
This study aimed to explore the influence of excess iodine on the articularcartilage and epiphyseal growth plate in rats. Wistar rats (n=200) were randomly divided into five groups with 40 rats in each: normal iodine (NI), 5-fold high iodine group (5HI), 10-fold high iodine group (10HI),50-fold high iodine group (50HI), 100-fold high iodine group (100HI). The rats were executed in 6 and 12 months. 24-hour urinary iodine concentration (UIC) was monitored by arsenic-cerium catalytic spectrophotometry. The chemiluminescence method was used to determine the thyroid function. The pathological changes in the epiphyseal plate, articular cartilage, and thickness of the epiphyseal plate were observed. The mRNA expression of Collagen II (ColII), Collagen X, matrix metalloproteinase-13 (MMP-13), and fibroblast growth factor receptor 1 in articular chondrocytes was detected by RT-PCR. 24-h UIC increased as iodine intake increased. In the 12th month, there were a significant increase in serum sTSH and a decrease in serum FT4 in HI groups, compared to the NI group. There was a decrease in the number of proliferating cells in the epiphyseal plate and an increase in the number of mast cell layers. The chondrocytes appeared disorganized and the tidal lines were disturbed or even broken. Growth plate thickness decreased with increasing iodine intake. Compared with the NI group, ColII and MMP-13 mRNA expression in chondrocytes in all HI groups significantly increased. Chronic iodine overdose increases the risk of hypothyroidism, which leads to abnormal morphology of epiphyseal growth plates and articular cartilage, increasing the risk of osteoarthritis.