bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Arousa Island bridge. Complete refurbishment and 10 years analysis description
Authors: Becerra‐Mosquera José Antonio , Carro‐López Diego , Herrador Manuel F. 
Published: January 2024

AbstractThe Isla de Arousa Bridge, 1980 m long, is the only road access to Isla de Arousa. Built in 1985, this single‐cell box girder divided into 40 spans runs entirely over the sea. In response to corrosion damage, the local government decided to make an intervention with an ambitious repair project in 2009. The repair, carried out with three different techniques, aims to collect data for future repairs. In this research the results of rehabilitation and comparison of the evolution of the repairs are described, together with the data on the progression of corrosion and its effect on the life cycle. At the moment, with data from 10 years of protection, both hybrid and galvanic anodes installation have shown effectiveness. Bridge Health index analysis shows that after reparation, the bridge presented a very good condition, and even after 10 years the condition is still good, except for some damaged bearings.
TTA‐Rapid for treating the canine cruciate deficient stifle: Medium to long‐term outcome and analysis of risk factors
Authors: Butterworth Steven J. , Schofield Imogen 
Published: January 2024

AbstractBackgroundThis study aimed to evaluate medium to long‐term outcomes following treatment of lameness associated with cranial cruciate ligament insufficiency using the tibial tuberosity advancement (TTA)‐Rapid technique and to investigate risk factors associated with outcome, including tibial plateau angle (TPA).MethodsPatient records for cases treated over an 80‐month period were examined retrospectively. An owner postal questionnaire using a clinical metrology instrument (Liverpool Osteoarthritis in Dogs) evaluated the outcome at least 6 months after surgery.ResultsA total of 149 procedures were carried out in 120 dogs. Questionnaires were received for 64 dogs (53.3%), with a median follow‐up time of 37.5 months. Outcome was judged to be satisfactory, based on frequency of lameness, in 63 (98.4%), while satisfactory outcomes were achieved in 61 (95.3%) based on severity of lameness and in 50 (78.1%) based on mobility score. Statistical analysis showed that age, bodyweight, TPA, meniscal injury and concurrent patellar surgery did not influence outcome, but time to follow‐up positively correlated with mobility score.LimitationsThis study involved one surgeon in one centre with outcome data based on the completion of an owner questionnaire, although this used a validated clinical metrology instrument.ConclusionTTA‐Rapid offers a treatment option for cranial cruciate‐deficient stifles with a good medium to long‐term outcome, and no risk factors were identified to suggest any limitations to its use.
Increasing access to pediatric surgical care: Assessing district hospital readiness in rural Rwanda
Authors: Nuss Sarah R. , Nkurunziza Jonathan , Mugabo Carol , Kubwimana Marthe , Benimana Fanny , Uwera Cynthia , Nyirasabwa Theodette , Nyirimanzi Naphtal , Forbes Callum , Majyambere Jean Paul , Kateera Fredrick , Hedt‐Gauthier Bethany L. , Cubaka Vincent K. 
Published: January 2024

AbstractIntroduction/BackgroundSafe and quality surgery is crucial for child health. In Rwanda, district hospitals serve as primary entry points for pediatric patients needing surgical care. This paper reports on the organizational readiness and facility capacity to provide pediatric surgery in three district hospitals in rural Rwanda.MethodsWe administered the Children's Surgical Assessment Tool, adapted for a Rwandan district hospital, to assess facility readiness across 5 domains (infrastructure, workforce, service delivery, financing, and training) at three Partners in Health supported district hospitals (Kirehe, Rwinkwavu, and Butaro District Hospitals). We used the Safe Surgery Organizational Readiness Tool (SSORT) to measure perceived individual and team readiness to implement surgical quality improvement interventions across 14 domains.ResultsNone of the facilities had a dedicated pediatric surgeon, and the most common barriers to pediatric surgery were lack of surgeon (68%), lack of physician anesthesiologists (19%), and inadequate infrastructure (17%). There were gaps in operating and recovery room infrastructure and information management for pediatric outpatients and referrals. In SSORT interviews (n = 47), the highest barriers to increasing pediatric surgery capacity were facility capacity (mean score = 2.6 out of 5), psychological safety (median score = 3.0 out of 5), and resistance to change (mean score = 1.5 out of 5 with 5 = no resistance).ConclusionsThis study highlights challenges in providing safe and high‐quality surgical care to pediatric patients in three rural district hospitals in Rwanda. It underscores the need for targeted interventions to address facility and organizational barriers prior to implementing interventions to expand pediatric surgical capacity.
Analysis of radiative heat transfer on electro‐osmotic magneto nanofluid flow through ciliary propulsion
Authors: Imran Ali , Raja Muhammad Asif Zahoor , Awan Saeed Ehsan , Shoaib Muhammad 
Published: January 2024

AbstractA novel mathematical investigation is carried out to reveal the significance of thermal radiation on the dissipative magneto hydrodynamic electroosmotic ciliary propulsion of a Newtonian nanofluid (DMHECP‐NNF) in an symmetric micro‐channel by implementing the impact of an axial electrical as well as transverse magnetic fields. The ciliary transport model is explored by using conservation of mass and momentum, heat, nanoparticle concentration, and electric potential expressions along with associated boundary conditions. The pertinent system for the proposed flow problem DMHECP‐NNF consisting of partial differential equations are converted into ordinary differential equations system by incorporating the strengths dimensionless mechanism. Then analytical expressions are found for electrical potential, axial velocity, stream function, pressure gradient, temperature and concentration profiles. Whereas numerical computations are carried out to study transverse velocity and rise of pressure as per wavelength. The impacts of significant physical quantities of DMHECP‐NNF are investigated with the help of graphical manipulations. It is observed in this novel study that axial velocity rises initially and then decline with increase in the magnitude of electro‐osmotic parameter and Helmholtz‐Smoluchowski velocity. Also, it is seen that with the rising value of electric‐osmotic parameter the complexion of the trapped bolus is inflated and surrounded by few streamlines.
Mentalization-Oriented Metacognitive Theory of Psychodrama
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractPsychodrama therapists need to explainbetterwhat they do in therapy when they do what they do (Marineau 2011, p. 43). Therole theoriesare not sufficient to justify thespecific therapeutic effects of psychodrama therapy. The cross-analytical concept of mentalizing gives anew scientific basisto the profound emotional experiences inclassical psychodrama:Psychodrama is inner mentalizing through external play in the as-if mode.1. The therapistintuitivelyuses the patient’s metacognitive tools of inner mentalizing as external action modes. Doing this, inner representing, interacting, rehearsing mentally, and integrating become external scene construction, role play, role reversal, and scene change. This knowledge helps to treat the patient's disturbedmetacognitiveprocessesdirectlyin adisorder-specific mannerwith a lot of timein the right place.2. The psychodramaticexternal action in the as-if modecompletes the associated neuronal resonance circuits between the various memory centerswith new elements. According to Moreno (1970, p. 77), this gives rise to the “true second time, which liberates from the first”. The concept of mentalizing explains why psychodrama therapy is not only used in groups, butalso in individual settings. Behavioral therapy, systemic therapy, and depth psychological therapy are increasingly integrating the disorder-specific psychodramaticaction methodsinto their own therapeutic work.
Anxiety Disorders
Authors: Krüger Reinhard T. 
Published: January 2024

AbstractAnxiety disorders are the most common mental disorders in developed countries. They include valid real fears, neurotic fears, and fears of structural disorders. The type of anxiety is the guiding principle for the disorder-specific psychodramatic approach. Panic attacks are caused by the imminent collapse of an old self-protection through perfectionism. The therapist therefore places chairs next to the patient to externally symbolize the patient’s symptoms in everyday life and also his self-protection through perfectionism (ego-state), which threatens to collapse in anxiety provoking situations. In disorder-specific psychodrama therapy, the patient traces his dysfunctional self-regulation in his symptom production in the as-if mode of play. In doing so, he understands himself for the first time. He gains ego control over his symptom production and spontaneously finds alternative courses of action. Thus, the therapist first works directly on the metacognitive processes that cause the panic and the dysfunctional thought content. This opens up access to the patient’s underlying conflicts.
Beweggründe von Patienten, die sich selbständig in der Notaufnahme vorstellen – eine prospektive monozentrische Beobachtungsstudie
Authors: Sitter Katharina , Braunstein Mareen , Wörnle Markus 
Published: January 2024

Zusammenfassung
Hintergrund
In der aktuellen fachlichen, gesellschaftlichen und politischen Diskussion wird immer wieder die These aufgestellt, dass ein Großteil der Patienten, die selbständig die Notaufnahme aufsuchen, auch in anderen Versorgungsbereichen wie beim Hausarzt, dem kassenärztlichen Bereitschaftsdienst oder in Notfallpraxen behandelt werden könnte. Verschiedene Gründe werden aufgeführt, warum diese alternativen Versorgungsbereiche in diesen Fällen nicht genutzt werden.

Ziel der Arbeit
In unserer Arbeit untersuchten wir die Beweggründe von Patienten, die sich selbständig in der Notaufnahme vorstellten, sowie soziodemografische Parameter dieses Studienkollektivs.

Material und Methoden
Die Erhebung erfolgte im Rahmen einer prospektiven monozentrischen Beobachtungsstudie an internistischen Patienten einer universitären Notaufnahme in Innenstadtlage.

Ergebnisse
1086 Patienten konnten in die Studie eingeschlossen werden. 33 % der Studienteilnehmer besuchten die Notaufnahme aufgrund einer ärztlichen Empfehlung bzw. Einweisung anstelle einer alternativen Versorgungsmöglichkeit. Der Hauptgrund für den Besuch der Notaufnahme war die subjektiv beurteilte Dringlichkeit der Beschwerden. 28 % der Patienten, die sich selbständig in der Notaufnahme vorstellten, mussten im Verlauf stationär weiterversorgt werden. Die Kenntnis von alternativen Versorgungswegen wie einer Inanspruchnahme des Rettungsdiensts, der Vorstellung beim kassenärztlichen Bereitschaftsdienst oder dem Besuch von Notfallpraxen war gering.

Diskussion
Die Notaufnahmen sind nach wie vor eine wichtige Anlaufstelle für Patienten, die sich dort selbständig und ohne Einlieferung mit dem Rettungsdienst vorstellen. Die Beweggründe, warum die Patienten einen Besuch der Notaufnahme einer Behandlung in einer alternativen Versorgungsstruktur vorziehen, sind unterschiedlich. Wenn Alternativen anstatt Notaufnahmen genutzt werden sollen, so müssen hier erst Strukturen aufgebaut bzw. erweitert werden.
Bone marrow-derived mesenchymal stromal cells obstruct AML-targeting CD8+ clonal effector and CAR T-cell function while promoting a senescence-associated phenotype
Authors: Towers Russell , Trombello Lidia , Fusenig Maximilian , Tunger Antje , Baumann Anna-Lena , Savoldelli Roberto , Wehner Rebekka , Fasslrinner Frederick , Arndt Claudia , Dazzi Francesco , Von Bonin Malte , Feldmann Anja , Bachmann Michael P. , Wobus Manja , Schmitz Marc , Bornhäuser Martin 
Published: January 2024

AbstractBone marrow mesenchymal stromal cells (MSCs) have been described as potent regulators of T-cell function, though whether they could impede the effectiveness of immunotherapy against acute myeloid leukemia (AML) is still under investigation. We examine whether they could interfere with the activity of leukemia-specific clonal cytotoxic T-lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells, as well as whether the immunomodulatory properties of MSCs could be associated with the induction of T-cell senescence. Co-cultures of leukemia-associated Wilm’s tumor protein 1 (WT1) and tyrosine-protein kinase transmembrane receptor 1 (ROR1)-reactive CTLs and of CD123-redirected switchable CAR T cells were prepared in the presence of MSCs and assessed for cytotoxic potential, cytokine secretion, and expansion. T-cell senescence within functional memory sub-compartments was investigated for the senescence-associated phenotype CD28−CD57+ using unmodified peripheral blood mononuclear cells. We describe inhibition of expansion of AML-redirected switchable CAR T cells by MSCs via indoleamine 2,3-dioxygenase 1 (IDO-1) activity, as well as reduction of interferon gamma (IFNγ) and interleukin-2 (IL-2) release. In addition, MSCs interfered with the secretory potential of leukemia-associated WT1- and ROR1-targeting CTL clones, inhibiting the release of IFNγ, tumor necrosis factor alpha, and IL-2. Abrogated T cells were shown to retain their cytolytic activity. Moreover, we demonstrate induction of a CD28loCD27loCD57+KLRG1+ senescent T-cell phenotype by MSCs. In summary, we show that MSCs are potent modulators of anti-leukemic T cells, and targeting their modes of action would likely be beneficial in a combinatorial approach with AML-directed immunotherapy.
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy
Authors: Wen Yuqing , Ye Shuyu , Li Zhengshuo , Zhang Xiaoyue , Liu Can , Wu Yangge , Zheng Run , Xu Chenxiao , Tian Junrui , Shu Lanjun , Yan Qun , Ai Feiyan , Ma Jian 
Published: January 2024

AbstractThe search for effective combination therapy with immune checkpoint inhibitors (ICI) has become important for cancer patients who do not respond to the ICI well. Histone deacetylases (HDACs) inhibitors have attracted wide attention as anti-tumor agents. ACY-1215 is a selective inhibitor of HDAC6, which can inhibit the growth of a variety of tumor. We previously revealed that HDAC family is highly expressed in colorectal cancer specimens and mouse models. In this study, ACY-1215 was combined with anti-PD1 to treat tumor-bearing mice associated with colorectal cancer. ACY-1215 combined with anti-PD1 effectively inhibited the colorectal tumor growth. The expression of PD-L1 in tumor of mice were inhibited by ACY-1215 and anti-PD1 combination treatment, whereas some biomarkers reflecting T cell activation were upregulated. In a co-culture system of T cells and tumor cells, ACY-1215 helped T cells to kill tumor cells. Mechanically, HDAC6 enhanced the acetylation of STAT1 and inhibited the phosphorylation of STAT1, thus preventing STAT1 from entering the nucleus to activate PD-L1 transcription. This study reveals a novel regulatory mechanism of HDAC6 on non-histone substrates, especially on protein acetylation. HDAC6 inhibitors may be of great significance in tumor immunotherapy and related combination strategies.
H3 K27M mutation in rosette-forming glioneuronal tumors: a potential diagnostic pitfall
Authors: Marastoni Elena , Ammendola Serena , Rossi Sabrina , Giovannoni Isabella , Broggi Giuseppe , Masotto Barbara , Feletti Alberto , Barresi Valeria 
Published: January 2024

AbstractAccording to the fifth edition of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS), diffuse midline glioma H3 K27-altered is a grade 4 infiltrative glioma that arises from midline anatomical structures and is characterized by the loss of H3 K27me3 and co-occurring H3 K27M mutation or EZHIP overexpression. However, the H3 K27M mutation has also been observed in circumscribed gliomas and glioneuronal tumors arising in midline anatomical structures, which may result in diagnostic pitfalls.Rosette-forming glioneuronal tumor (RGNT) is a CNS WHO grade 1 neoplasm that histologically features neurocytic and glial components and originates in midline anatomical structures.This study aimed to assess whether RGNTs, similar to other midline tumors, may exhibit immunohistochemical loss of H3 K27me3 and harbor the H3 K27M mutation.All seven analyzed RGNTs displayed immunohistochemical loss of H3 K27me3 in all tumor cells or H3 K27me3 mosaic immunostaining. In one case, H3 K27me3 loss was associated with the H3 K27M mutation, whereas the other six cases did not exhibit any H3 mutations or EZHIP overexpression. During a follow-up period of 23 months, the H3 K27M-mutant case remained unchanged in size despite partial resection, indicating that the H3 mutation may not confer higher biological aggressiveness to RGNT.The immunohistochemical loss of H3 K27me3 co-occurring with the H3 K27M mutation may result in the potential misdiagnosis of RGNT, especially in cases of small biopsy specimens consisting of only the glial component.
Influence of carbon structure/porosity on the electrochemical performance in Li–sulfur batteries
Authors: Pitňa Lásková Barbora , Zukalová Markéta , Vinarčíková Monika , Kavan Ladislav 
Published: January 2024

AbstractThe porous structure of three different, commercially available porous carbonaceous materials is investigated by the αS-plot method and by the t-plot method. Subsequently, the electrochemical properties of sulfur-free porous carbon electrodes from inspected materials are studied by cyclic voltammetry. The comparison of double-layer capacitances with the corresponding adsorption isotherms of N2 reveals the role of micropores during the capacitive charging of carbons by Li+. The studied carbons are added to the sulfur cathodes and evaluated. The cyclic voltammograms show no contribution of micropores in the carbon structure to the electrochemical processes taking place in the lithium–sulfur coin cell. The highest specific capacity of 816 mAh/g is observed for material with the lowest content of micropores in the structure (14%). The partially mesoporous and partially microporous (65%) sample and the predominantly microporous one (87%), show specific capacities of 664 mAh/g and 560 mAh/g, respectively. The galvanostatic cycling of lithium–sulfur coin cells with carbonaceous additives reveals that the mesopores and macropores in the carbon structure increase the specific charge capacity of the lithium–sulfur batteries and that the micropores improve the cycling stability of these batteries.
Graphical abstract
Mixed reality holograms for percutaneous lead extraction of cardiac implantable electronic devices
Authors: Valverde Israel , Gomez Gorka , de Alarcón González Arístides , Sierra Antonio , Perez Adriano , Hussain Tarique , Pushparajah Kuberan , Ordoñez Antonio , Gutiérrez Carretero Encarnación 
Published: January 2024

AbstractTo assess the potential of mixed reality holograms (MixR) based on CT images to improve percutaneous lead extraction (PLE) planning and intraoperative assistance. This was a prospective, controlled, single-centre study. Five patients with CIED infection for PLE were included in the study. Conventional imaging (chest radiograph and CT) and MixR holograms were evaluated for preoperative planning to identify common complications such as vascular thrombosis, broken leads, loops, kinking, fibrosis along the wires, and perforation of cardiovascular structures. The degree of difficulty of the procedure was estimated based on potential complications. After the PLE procedure, the level of concordance between conventional imaging and MixR holograms with intraoperative findings was evaluated. The utility of MixR intraoperative guidance was also assessed. MixR holograms demonstrated a very high correlation in predicting the presence of loops, kinking, and fibrosis compared to conventional imaging, which showed a low-to-high correlation. MixR also showed a high correlation in estimating the degree of difficulty of the procedure compared to conventional imaging, which tended to underestimate it. The surgeon who performed the PLE agreed that MixR was helpful during intraoperative assistance. MixR holograms based on CT images are an effective tool for understanding cardiovascular anatomy and detecting potential areas of complications. MixR may be used as a complementary tool for both preoperative planning and intraoperative assistance in PLE procedures.
Graphical abstract
Mixed reality holograms for intraprocedural intervention assistance.
Validation of the Italian version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS) in an Italian Parkinson’s disease cohort
Authors: Maggi Gianpaolo , Vitale Carmine , Giacobbe Chiara , Barone Angelo , Mastromarino Clara , Iannotta Federica , Amboni Marianna , Weintraub Daniel , Santangelo Gabriella 
Published: January 2024

Abstract
Introduction
Impulse control disorders (ICDs) frequently occur in Parkinson’s disease (PD), and an early identification is essential to prevent severe psychosocial consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease–Rating Scale (QUIP-RS) has been developed to evaluate the severity of ICDs along with a range of impulsive-compulsive behaviors (ICBs) in PD; however, its Italian version has not yet been validated.

Methods
One hundred consecutive outpatients with PD were administered an Italian version of the QUIP-RS and a brief neuropsychological assessment to evaluate global cognitive status and scales to measure depression, apathy and impulsive disorders. We evaluated the internal consistency, convergent and divergent validity, and factorial structure of QUIP-RS. We also explored the possible association between QUIP-RS scores and clinical factors and dopaminergic medication.

Results
Subsyndromal ICDs manifestations were observed in 54% of the patients, and one in four (22%) reported two or more ICDs or related behaviors. The QUIP-RS demonstrated good internal consistency (Cronbach’s alpha = 0.806) and construct validity, and its factorial structure reflected different ICDs and ICBs domains. No association emerged between QUIP-RS scores and the clinical aspects of PD and dopaminergic medication.

Conclusion
We provided, for the first time, an Italian translation of the QUIP-RS and demonstrated its feasibility in clinical and research settings. Severity of ICDs was independent of clinical factors and dopaminergic medication, underlining the need to adopt a broader perspective on their etiopathology in PD.