bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of inherent properties of the carboxymethyl cellulose (CMC) for potential application in tissue engineering focusing on bone regeneration
Authors: Mehrabi Arezou , Jalise Saeedeh Zare , Hivechi Ahmad , Habibi Sina , Kebria Maziar Malekzadeh , Haramshahi Mohammad Amin , Latifi Noorahmad , Karimi Afzal , Milan Peiman Brouki 
Published: December 2023

AbstractBiomaterials are essential in medicine because these biological macromolecules have appropriately replaced classical tissue grafting techniques for their valuable features. Bone tissue engineering has persistently developed since “tissue engineering” was suggested. Carboxymethyl cellulose (CMC) is the first FDA‐approved water‐soluble derivative of cellulose that could be targeted for desired bone tissue graft. Numerous studies on CMC as a component created for bone tissue have recently been published. Because of its carboxylate groups, CMC is hydrophilic. CMC can crosslink with varied materials, such as synthetic and natural polymers, enabling innovative bone structure biomaterials. These carboxylate groups are responsible for in situ gelations and bio‐adhesion characteristics. In this review, the current progress and inherent characteristics of CMC‐based bone scaffold materials are discussed.
Gaps in diagnosing suspected infection in immunocompromised children with cancer: A systematic review
Authors: Park Sarah Y. , Coufal Nicole G. , Dominguez Samuel R. , Farnaes Lauge , Messacar Kevin , Goldman Frederick D. 
Published: December 2023

AbstractWhile the survival of children with cancer has improved over time, infection remains a major morbidity and mortality risk. We conducted a systematic literature review to determine the unmet needs in diagnosing infection in immunocompromised children with cancer. The comprehensive search strategy followed the guidelines established by the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) 2020 statement, and spanned multiple bibliographic databases and other public sources from January 1, 2012 to June 23, 2022. From 5188 records, 34 unique pediatric‐focused studies met inclusion criteria. This review highlights the lack of published data on infectious disease testing in pediatric oncology patients, and the need for well‐designed clinical impact and cost‐effectiveness studies of both existing and novel diagnostic platforms. Such studies are necessary to optimize diagnostic and antimicrobial stewardship, leading to improvement in patient outcomes.
The influence of thickness and recycled milled glass fiber fillers on the delamination resistance of polymer composite angle brackets
Authors: Venkatesan Dinesh Babu , Vellayaraj Arumugam , Chelliah Suresh Kumar 
Published: December 2023

AbstractComposite structures with L, C, and T shape geometries are commonly used in the design of aerospace structural components. These complex structures are prone to delamination failure at the curved region. This study investigates the effect of thickness and recycled milled glass fiber fillers to improve the strength properties and delamination resistance of glass/epoxy composite angle brackets. Different thicknesses of 3.5 mm (16 layers), 5 mm (24 layers), and 6.5 mm (32 layers) specimens were subjected to four‐point bending test with acoustic emission (AE) monitoring for evaluating damage resistance. Mechanical results reveal that the specimen with a higher thickness of 6.5 mm has better damage tolerance, followed by 3.5 and 5 mm angle brackets. Moreover, the location of AE signals and % of AE hits noticed the initiation and propagation of delamination in 5 mm thickness specimen at the earlier stage of loading. However, the curved beam strength and interlaminar tensile strength (ILTS) of 5 mm thickness specimen were improved by 31.02% and 19.2% respectively, through the incorporation of 2 wt% of fillers. Further, the interfacial adhesion between the fillers and epoxy matrix was studied using Fourier‐transform infrared analysis to confirm the improvement of delamination resistance in 5 mm thickness specimen. Finally, the mechanical and AE results were well correlated with field emission scanning electron microscope images to characterize the damage mechanisms in composite angle brackets.Highlights
Effect of thickness on the delamination resistance of composites was studied.
Interlaminar properties of composite angle brackets were assessed.
Acoustic emission parameters were used to study the damage mechanisms.
Recycled milled glass fillers were employed to improve delamination resistance.
Mechanical and acoustic emission results were correlated with field emission scanning electron microscope images.
Human cord plasma proteomic analysis reveals sexually dimorphic proteins associated with intrauterine growth restriction
Authors: Akinyemi Ayodele Jacob , Du Xiu Quan , Aguilan Jennifer , Sidoli Simone , Hirsch David , Wang Tao , Reznik Sandra , Fuloria Mamta , Charron Maureen J. 
Published: December 2023

AbstractIntrauterine growth restriction (IUGR) is associated with increased risk of cardiometabolic disease later in life and has been shown to affect female and male offspring differently, but the mechanisms remain unclear. The purpose of this study was to identify proteomic differences and metabolic risk markers in IUGR male and female neonates when compared to appropriate for gestational age (AGA) babies that will provide a better understanding of IUGR pathogenesis and its associated risks. Our results revealed alterations in IUGR cord plasma proteomes with most of the differentially abundant proteins implicated in peroxisome pathways. This effect was evident in females but not in males. Furthermore, we observed that catalase activity, a peroxisomal enzyme, was significantly increased in females (p < 0.05) but unchanged in males. Finally, we identified risk proteins associated with obesity, type‐2 diabetes, and glucose intolerance such as EGF containing fibulin extracellular matrix protein 1 (EFEMP1), proprotein convertase subtilisin/kexin type 9 (PCSK9) and transforming growth factor beta receptor 3 (TGFBR3) proteins unique to females while coagulation factor IX (C9) and retinol binding protein 4 (RBP4) are unique in males. In conclusion, IUGR may display sexual dimorphism which may be associated with differences in lifelong risk for cardiometabolic disease between males and females.
From Mysore to Cambridge and back: The education of a groundnut breeder
Authors: Brown Tad 
Published: December 2023

Societal Impact StatementStudies that show how empire influenced the development of plant genetics add to the established history of genetics and 20th‐century agricultural science. One approach to broadening this history is to consider the contributions of students studying abroad and their greater careers back home. Research agendas differed between and within institutions, much as they do today. This article explores the postgraduate education of an Indian groundnut breeder. It highlights the structural challenges faced by researchers at agricultural departments who sought promotion through education and examines the consequences for plant breeding and for farmers.Summary

Through the biography of V.K. Badami, this article contributes to debates about genetics and plant breeding in the history of science. Badami, an accomplished breeder in the Mysore Department of Agriculture, took a leave to study genetics at the University of Cambridge. His professors nearly failed him, yet Badami's groundnut breeding experiments proved influential for Indian farmers as well as advances in crop science. This history adds to the thesis that academic genetics varied in support of professional plant breeding by comparing institutional expections between Mysore and Cambridge.
The argument is developed by reading Badami's student records along with his groundnut breeding experiments in South India.
The study connects the disciplinary history of genetics to plant breeding for the British empire.
Badami's experience at Cambridge is indicative of the power relationship between academic genetics and imperial plant breeding in the early 20th century. In this case, his commitments as an Indian agricultural officer conflicted with the discipline's devotion to quantitative analysis.
Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N‐terminal domain
Authors: Geens Rob , Stanisich Jessica , Beyens Olivier , D'Hondt Stijn , Thiberge Jean‐Michel , Ryckebosch Amber , De Groot Anke , Magez Stefan , Vertommen Didier , Amino Rogerio , De Winter Hans , Volkov Alexander N. , Tompa Peter , Sterckx Yann G.‐J. 
Published: December 2023

AbstractThe circumsporozoite protein (CSP) is the main surface antigen of the Plasmodium sporozoite (SPZ) and forms the basis of the currently only licensed anti‐malarial vaccine (RTS,S/AS01). CSP uniformly coats the SPZ and plays a pivotal role in its immunobiology, in both the insect and the vertebrate hosts. Although CSP's N‐terminal domain (CSPN) has been reported to play an important role in multiple CSP functions, a thorough biophysical and structural characterization of CSPN is currently lacking. Here, we present an alternative method for the recombinant production and purification of CSPN from Plasmodium falciparum (PfCSPN), which provides pure, high‐quality protein preparations with high yields. Through an interdisciplinary approach combining in‐solution experimental methods and in silico analyses, we provide strong evidence that PfCSPN is an intrinsically disordered region displaying some degree of compaction.
Transmembrane proteins—Different anchoring systems
Authors: Roterman Irena , Stapor Katarzyna , Konieczny Leszek 
Published: December 2023

AbstractTransmembrane proteins are active in amphipathic environments. To stabilize the protein in such surrounding the exposure of hydrophobic residues on the protein surface is required. Transmembrane proteins are responsible for the transport of various molecules. Therefore, they often represent structures in the form of channels. This analysis focused on the stability and local flexibility of transmembrane proteins, particularly those related to their biological activity. Different forms of anchorage were identified using the fuzzy oil‐drop model (FOD) and its modified form, FOD‐M. The mainly helical as well as β‐barrel structural forms are compared with respect to the mechanism of stabilization in the cell membrane. The different anchoring system was found to stabilize protein molecules with possible local fluctuation.
Risk assessment of liquid ammonia tanks based on Bayesian network and Probit model
Authors: Zhang Cheng , Wang Ziyun , Chen Xingbai , Xiang Yue 
Published: December 2023

AbstractThis paper presents a quantitative risk assessment method to predict the potential risks of liquid ammonia tanks. The method combines probabilistic prediction and consequence assessment: the former is predicted by Bayesian networks derived from bow‐tie mapping, in which the conditional probabilities are determined by analytic hierarchy process, the latter is calculated based on numerical simulation of accident consequences and Probit probability model. The application results show that the method can be used for quantitative risk assessment of liquid ammonia storage tank, and the Bayesian network model is efficient and stable, which can realize risk prediction, accident causes analysis and risk mitigation analysis. Human errors during production or maintenance and corrosion are the main causes of liquid ammonia leakage. Toxicity has the greatest effect on the risk of liquid ammonia tanks. Risk mitigation measures can significantly reduce individual risk and societal risk. The obtained results provide meaningful guidance for the prevention and risk mitigation strategies of liquid ammonia leakage accidents, so as to improve the safety level of liquid ammonia during storage.
Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model
Authors: Ippolito Alberto , Wang Hanwen , Zhang Yu , Vakil Vahideh , Bazzazi Hojjat , Popel Aleksander S. 
Published: December 2023

AbstractConditionally activated molecules, such as Probody therapeutics (PbTx), have recently been investigated to improve antitumoral response while reducing systemic toxicity. PbTx are engineered to be proteolytically activated by proteases that are preferentially active locally in the tumor microenvironment (TME). Here, we perform an exploratory study using our recently published quantitative systems pharmacology model, previously validated for other drugs, to evaluate the effectiveness and targeting specificity of an anti‐PD‐L1 PbTx compared to the non‐modified antibody. We have informed the model using the PbTx dynamics and pharmacokinetics published in the literature for anti‐PD‐L1 in patients with triple‐negative breast cancer (TNBC). Our results suggest masking of the antibody slightly decreases its efficacy, while increasing the localization of active therapeutic component in the TME. We also perform a parameter optimization for the PbTx design and drug dosing regimens to maximize the response rate. Although our results are specific to the case of TNBC, our findings are generalizable to any conditionally activated PbTx molecule in solid tumors and suggest that design of a highly effective and selective PbTx is feasible.
Identification, characterisation and in silico ADMET prediction of ozenoxacin and its degradation products using high‐performance liquid chromatography‐photodiode array and liquid chromatography‐quadrupole time‐of‐flight‐tandem mass spectrometry
Authors: Matta Ashwinkumar , Sundararajan Raja 
Published: December 2023

RationaleOzenoxacin (OXC) is an antibiotic used topically to treat impetigo. This study aimed to evaluate the degradation products (DP) of OXC drug substance under different stress conditions, including hydrolysis, oxidation, thermal and photolysis, in accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines Q1A(R2) and Q1B. The analytical technique was validated in compliance with ICH Q2(R1) requirements.MethodsThe drug substance underwent degradation under various forced degradation conditions, including thermal, oxidative, photolytic and hydrolytic (neutral, acidic and basic) degradation. Overall, four DPs were formed under oxidative stress conditions with AIBN. The formed DPs were identified and separated using a Shimadzu LC system with a reversed‐phase Phenomenex Kinetex C18 column (4.6 × 250 mm, 5 μm), using 10 mM NH4CH3COOH buffer (pH −5.0) as mobile phase A and acetonitrile as mobile phase B at a detection wavelength of 254 nm.Results and ConclusionThe drug was found to be stable in neutral, acidic, basic and oxidative degradation conditions with hydrogen peroxide. Liquid chromatography‐electrospray ionisation‐quadrupole time‐of‐flight‐tandem mass spectrometry‐ was employed in positive ionisation mode to analyse both the drug and the mass of the identified DP. The mechanism and the pathway of mass fragmentation have been proposed. The developed method was accurate, repeatable, linear and selective for further research. The ADMET Predictor software was applied to predict the in silico toxicity of the drugs and its DPs as well as their physicochemical characteristics.
Ecological traits of Saliceae and the species replacing them on the active floodplain
Authors: Edwards Peter J. 
Published: December 2023

AbstractThe dominant woody plants of active floodplains in the northern temperate zone are various species of Salix (willows) and Populus (poplars and cottonwoods) in the tribe Saliceae of the family Salicaceae. In this review, I consider the traits that enable these species to thrive in the dynamic floodplain environment and ask why they are now declining in the northern hemisphere, yet spreading rapidly in the southern hemisphere. I reach four main conclusions. First, floodplain Saliceae exhibit traits, notably huge numbers of minute, wind‐ and water‐dispersed seeds and an exceptional capacity for vegetative propagation, that uniquely fit them for life on the active floodplain. Second, there are no functional equivalents to floodplain Salix and Populus in the southern hemisphere, which accounts for their remarkable success in invading riparian ecosystems. Third, the replacement of Saliceae by other species in the northern hemisphere has been caused mainly by changes in flow through dam construction, regulation and abstraction. The species that replace Saliceae vary according to site conditions: fertile sites in humid climates become occupied by various broadleaved trees (e.g., Acer negundo, Fraxinus pennsylvanica, Ailanthus altissima); nitrogen‐fixing shrubs dominate in areas where nitrogen is limiting but phosphorus is adequate (Amorpha fruticosa, Robinia pseudoacacia, Elaeagnus angustifolia); sites in more arid regions are occupied by various Tamarix spp. The different ecological groups of woody species are associated with contrasting changes to the floodplain ecosystem.
High Thermoelectric Performance Related to PVDF Ferroelectric Domains in P‐Type Flexible PVDF‐Bi0.5Sb1.5Te3 Composite Film
Authors: Jiang Qinghui , Pan Deng , Wang Yunfan , Liu Yong , Luo Yubo , Yang Junyou , Li Baowen , Dunn Steve , Yan Haixue 
Published: December 2023

AbstractThere is increasing demand to power Internet of Things devices using ambient energy sources. Flexible, low‐temperature, organic/inorganic thermoelectric devices are a breakthrough next‐generation approach to meet this challenge. However, these systems suffer from poor performance and expensive processing preventing wide application of the technology. In this study, by combining a ferroelectric polymer (Polyvinylidene fluoride (PVDF, β phase)) with p‐type Bi0.5Sb1.5Te3 (BST) a thermoelectric composite film with maximum is produced power factor. Energy filter from ferroelectric‐thermoelectric junction also leads to high Seebeck voltage ≈242 µV K−1. For the first time, compelling evidence is provided that the dipole of a ferroelectric material is helping decouple electron transport related to carrier mobility and the Seebeck coefficient, to provide 5× or more improvement in thermoelectric power factor. The best composition, PVDF/BST film with BST 95 wt.% has a power factor of 712 µW•m−1 K−2. A thermoelectric generator fabricated from a PVDF/BST film demonstrated PmaxT 12.02 µW and Pdensity 40.8 W m−2 under 50 K temperature difference. This development also provides a new insight into a physical technique, applicable to both flexible and non‐flexible thermoelectrics, to obtain comprehensive thermoelectric performance.
Liquid Crystalline Network Microstructures for Stimuli Responsive Labels with Multi‐Level Encryption
Authors: Donato Simone , Nocentini Sara , Martella Daniele , Kolagatla Srikanth , Wiersma Diederik S. , Parmeggiani Camilla , Delaney Colm , Florea Larisa 
Published: December 2023

AbstractTwo‐photon direct laser writing enables the fabrication of shape‐changing microstructures that can be exploited in stimuli responsive micro‐robotics and photonics. The use of Liquid Crystalline Networks (LCN) allows to realize 3D micrometric objects that can contract along a specific direction in response to stimuli, such as temperature or light. In this paper, the fabrication of free‐standing LCN microstructures is demonstrated as graphical units of a smart tag for simple physical and optical encryption. Using an array of identical pixels, information can be hidden to the observer and revealed only upon application of a specific stimulus. The reading mechanism is based on the shape‐change of each pixel under stimuli and their color that combine together in a two‐level encryption label. Once the stimulus is removed, the pixels recover their original shape and the message remains completely hidden. Therefore, an opto‐mechanical equivalent of an “invisible ink” is realized. This new concept paves the way for introducing enhanced functionalities in smart micro‐systems within a single lithography step, spanning from storage devices with physical encryption to complex motion actuators.
Hierarchical‐Pore‐Stabilization Strategy for Fabricating 18.3 wt% High‐Loading Single‐Atom Catalyst for Oxygen Reduction Reaction
Authors: He Tianxi , Zhang Xiaoyuan , Li Dan , Qin Yanyang , Zhao Hongyang , Wei Yuantao , Wang Yang , Chen Shenghua , Ding Shujiang , Xiao Chunhui 
Published: December 2023

AbstractMetal single‐atom catalysts (M‐SACs) attract extraordinary attention for promoting oxygen reduction reaction (ORR) with 100% atomic utilization. However, low metal loading (usually less than 2 wt%) limits their overall catalytic performance. Herein, a hierarchical‐structure‐stabilization strategy for fabricating high‐loading (18.3%) M‐SACs with efficient ORR activity is reported. Hierarchical pores structure generated with high N content by SiO2 can provide more coordination sites and facilitate the adsorption of Fe3+ through mesoporous and confinement effect of it stabilizes Fe atoms in micropores on it during pyrolysis. High N content on hierarchical pores structure could provide more anchor sites of Fe atoms during the subsequent secondary pyrolysis and synthesize the dense and accessible Fe‐N4 sites after subsequent pyrolysis. In addition, Se power is introduced to modulate the electronic structure of Fe‐N4 sites and further decrease the energy barrier of the ORR rate‐determining step. As a result, the Fe single atom catalyst delivers unprecedentedly high ORR activity with a half‐wave potential of 0.895 V in 0.1 M KOH aqueous solution and 0.791 V in 0.1 M HClO4 aqueous solution. Therefore, a hierarchical‐pore‐stabilization strategy for boosting the density and accessibility of Fe‐N4 species paves a new avenue toward high‐loading M‐SACs for various applications such as thermocatalysis and photocatalysis.
Zn‐In Alloying Powder Solvent Free Electrode Toward High‐Load Ampere‐Hour Aqueous Zn‐Mn Secondary Batteries
Authors: Wu Jian‐Chun , Shen Xicheng , Zhou Haitao , Li Xiaowei , Gao Hongquan , Ge Jingyi , Xu Teng , Zhou Haiyun 
Published: December 2023

AbstractAqueous Zn‐ion batteries (ZIBs) are promising candidates for large‐scale energy storage due to high safety, abundant reserves, low‐cost, and high energy density. However, the reversibility of the metallic Zn anode in the mild electrolyte is still unsatisfactory, due to the Zn dendrite growth, hydrogen evolution, and corrosion passivation. Herein, a Zn‐In alloying powder solvent free electrode is proposed to replace the Zn foil in ZIBs. The novel Zn anodes are constructed by a solvent‐free manufacturing process with carbons, forming a 3D Zn deposition network and providing uniformly electric field distribution. The In on the Zn powder surface can increase the overpotential for hydrogen evolution and further improve the morphology of Zn deposition against dendrite growth. The Zn solvent‐free electrodes enable the Zn‐MnO2 batteries with high cathode loading mass of 10–20 mg cm−2 to achieve >380 stable cycles. Furthermore, the assembled soft package batteries of 2.4 Ah (52 Wh kg−2) is evaluated and the capacity retention is maintained at 80% after 200 cycles at a high areal capacity of 5 mAh cm−2 without gas evolution. This work offers a workable strategy to develop a durable Zn anode for the eventually commercial applications of aqueous Zn‐Mn secondary batteries.