bluuebunny/crossref_metadata_2025_split huggingface dataset:
Requirements and methods of protection of copyright and related rights: correlation of concepts
Authors: Shtefan Olena 
Published: November 2023

This article is dedicated to distinguishing the concepts of «requirement» and «methods of protection». The need to distinguish between these concepts is related to the provision of civil procedural legislation, which contains various procedural consequences regarding the requirements and methods of protection that the plaintiff, through the court, applies to the defendant. It is the plaintiff who must exercise his right when applying to the court to determine his demands against the defendant and choose the way to protect his violated, unrecognized or disputed rights, freedoms or interests. The court has the duty to consider and decide the case exclusively within the limits of the stated requirements. At the same time, under certaincircumstances, the court may apply the method of protection that it considers effective, taking into account the specific circumstances of the case. Effective legal protection of copyright and/or related rights depends on the forms, methods and means ofprotection chosen by the subject of law. It should be taken into account that the requirements are specified in the methods of protection, which in turn are specified in the means of protection — sanctions. At the same time, «requirements», «methods of protection» and «means of protection» are different legal concepts, although they are mutually dependent.
The existing legal limitation of the court, led to the emergence of such concepts as «improper method of protection» and «ineffective method of protection» in the civil procedural doctrine and law enforcement practice of the court. If the plaintiff chooses an inappropriate method of defense when applying to the court, this becomes the basis for refusing to satisfy the claims, and if the plaintiff chooses an ineffective method of protecting the violated right, it leads to the refusal to satisfy the claims.
The conducted study of the provisions of material and procedural legislation allows us to talk about the need to make changes to the material legislation in order to clearly regulate the requirements, methods of protection and sanctions for violation of copyrightand/or related rights. In turn, such changes will make it possible to implement the general legal principle of legal certainty, which is a component of the principle ofthe rule of law.
Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8+ T cells
Authors: Lopes-Ribeiro Ágata , Oliveira Patrícia de Melo , Retes Henrique Morais , Barbosa-Stancioli Edel Figueiredo , da Fonseca Flávio Guimarães , Tsuji Moriya , Coelho-dos-Reis Jordana Grazziela Alves 
Published: November 2023

Introduction and methodsIn this present work, coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) were investigated for the presence of MHC-I immunodominant viral peptides using in silico and in vitro tools.ResultsIn our results, HLA-A*02 haplotype showed the highest number of immunodominant epitopes but with the lowest combined prediction score. Furthermore, a decrease in combined prediction score was observed for HLA-A*02-restricted epitopes when the original strain was compared to the VOCs, indicating that the mutations on the VOCs are promoting escape from HLA-A2-mediated antigen presentation, which characterizes a immune evasion process. Additionally, epitope signature analysis revealed major immunogenic peptide loss for structural (S) and non-structural (ORF8) proteins of VOCs in comparison to the Wuhan sequence.DiscussionThese results may indicate that the antiviral CD8+ T-cell responses generated by original strains could not be sufficient for clearance of variants in either newly or reinfection with SARS-CoV-2. In contrast, N epitopes remain the most conserved and reactive peptides across SARS-CoV-2 VOCs. Overall, our data could contribute to the rational design and development of new vaccinal platforms to induce a broad cellular CD8+ T cell antiviral response, aiming at controlling viral transmission of future SARS-CoV-2 variants.
Estimation of life expectancy and healthcare cost in rheumatoid arthritis patients with and without depression: a population-based retrospective cohort study
Authors: Chiu Ying-Ming , Lan Joung-Liang , Huang Wei-Lieh , Wu Chi-Shin 
Published: November 2023

PurposeThis study aimed to estimate the lifetime healthcare costs and loss of life expectancy (loss-of-LE) among patients with incident rheumatoid arthritis (RA) with and without depression.MethodsThis 18 years longitudinal cohort study used data from Taiwan’s National Health Insurance Research Database. In total, 43,311 patients with RA were included. Among them, 1,663 patients had depressive disorders in the year preceding the RA diagnosis. The survival function for patients with RA with or without depression was estimated and extrapolated over a lifetime using the rolling extrapolation algorithm. The loss-of-LE was calculated by comparing the sex, age, and calendar year-matched referents from vital statistics. The average monthly cost was calculated as the sum of the monthly costs for all patients divided by the number of surviving patients. Lifetime healthcare costs were estimated by multiplying the monthly average cost by the monthly survival probability.ResultsThe loss-of-LE for RA patients with and without depression was 5.60 years and 4.76 years, respectively. The lifetime costs of RA patients with and without depression were USD$ 90,346 and USD$ 92,239, respectively. However, the annual healthcare costs were USD$ 4,123 for RA patients with depression and USD$ 3,812 for RA patients without depression. Regardless of sex or age, RA patients with depression had higher annual healthcare costs than those without depression.ConclusionPatients with RA and depression have a high loss-of-LE and high annual healthcare costs. Whether treating depression prolongs life expectancy and reduces healthcare costs warrants further investigation.
Feasibility and safety study of wearable cyborg Hybrid Assistive Limb for pediatric patients with cerebral palsy and spinal cord disorders
Authors: Takahashi Kazushi , Mizukami Masafumi , Watanabe Hiroki , Kuroda Mayumi Matsuda , Shimizu Yukiyo , Nakajima Takashi , Mutsuzaki Hirotaka , Kamada Hiroshi , Tokeji Kayo , Hada Yasushi , Koseki Kazunori , Yoshikawa Kenichi , Nakayama Tomohiro , Iwasaki Nobuaki , Kawamoto Hiroaki , Sankai Yoshiyuki , Yamazaki Masashi , Matsumura Akira , Marushima Aiki 
Published: November 2023

IntroductionThe wearable cyborg Hybrid Assistive Limb (HAL) is the world’s first cyborg-type wearable robotic device, and it assists the user’s voluntary movements and facilitates muscle activities. However, since the minimum height required for using the HAL is 150 cm, a smaller HAL (2S size) has been newly developed for pediatric use. This study aimed to (1) examine the feasibility and safety of a protocol for treatments with HAL (2S size) in pediatric patients and (2) explore the optimal method for assessing the efficacy of HAL.MethodsThis clinical study included seven pediatric patients with postural and motor function disorders, who received 8–12 sessions of smaller HAL (2S size) treatment. The primary outcome was the Gross Motor Function Measure-88 (GMFM-88). The secondary outcomes were GMFM-66, 10-m walk test, 2- and 6-min walking distances, Canadian Occupational Performance Measure (COPM), a post-treatment questionnaire, adverse events, and device failures. Statistical analyses were performed using the paired samples t-test or Wilcoxon signed-rank test.ResultsAll participants completed the study protocol with no serious adverse events. GMFM-88 improved from 65.51 ± 21.97 to 66.72 ± 22.28 (p = 0.07). The improvements in the secondary outcomes were as follows: GMFM-66, 53.63 ± 11.94 to 54.96 ± 12.31, p = 0.04; step length, 0.32 ± 0.16 to 0.34 ± 0.16, p = 0.25; 2-MWD, 59.1 ± 57.0 to 62.8 ± 63.3, p = 0.54; COPM performance score, 3.7 ± 2.0 to 5.3 ± 1.9, p = 0.06; COPM satisfaction score, 3.3 ± 2.1 to 5.1 ± 2.1, p = 0.04.DiscussionIn this exploratory study, we applied a new size of wearable cyborg HAL (2S size), to children with central nervous system disorders. We evaluated its safety, feasibility, and identified an optimal assessment method for multiple treatments. All participants completed the protocol with no serious adverse events. This study suggested that the GMFM would be an optimal assessment tool for validation trials of HAL (2S size) treatment in pediatric patients with posture and motor function disorders.
Metabolic bulk volume from FDG PET as an independent predictor of progression-free survival in follicular lymphoma
Authors: So Heejune , Lee Hyunjong , Hyun Seung Hyup , Cho Young Seok , Moon Seung Hwan , Choi Joon Young , Lee Kyung-Han 
Published: November 2023

BackgroundTotal metabolic tumor volume (TMTV) in 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) predicts patient outcome in follicular lymphoma (FL); however, it requires laborious segmentation of all lesions. We investigated the prognostic value of the metabolic bulk volume (MBV) obtained from the single largest lesion.MethodsPretreatment FDG PET/computed tomography (CT) scans of 201 patients were analyzed for TMTV and MBV using a 41% maximum standardized uptake value (SUVmax) threshold.ResultsDuring a median follow-up of 3.2 years, 54 events, including 14 deaths, occurred. Optimal cut-offs were 121.1 cm3 for TMTV and 24.8 cm3 for MBV. Univariable predictors of progression-free survival (PFS) included a high Follicular Lymphoma International Prognostic Index 2 (FLIPI2) score, TMTV, and MBV. In the multivariable analysis, high TMTV and MBV were independent predictors of worse PFS (P =0.015 and 0.033). Furthermore, in a sub-group with FLIP2 scores of 0–2 (n = 132), high MBV could identify patients with worse PFS (P = 0.007). ConclusionReadily measurable MBV is useful for stratifying risk in FL patients.
Health status of the population in Naqu, Tibet and its latent class analysis: a cross-sectional survey
Authors: Cui Jiaxue , Nima Ouzhu , Zhaxi Duoji , Jin Chenxin , Wang Ruiqi , Diao Yizhuo , Chen Yongxing , Xu Xiaoguang , Li Xiaofeng 
Published: November 2023

BackgroundThrough a survey and analysis of the population’s present state of health, it is possible to give data support for improving the health status of inhabitants in Naqu, Tibet. Additionally, it is possible to provide specific recommendations for the development of medical and healthcare facilities in Tibet.MethodsThe health scores of the participants were based on their responses to the four main sections of the questionnaire: dietary habits, living habits, health knowledge, and clinical disease history, and the variability of health status among groups with different characteristics was analyzed based on the scores. The four major sections were used to create classes of participants using latent class analysis (LCA). Using logistic regression, the factors influencing the classification of latent classes of health status were investigated.ResultsA total of 995 residents from 10 counties in Naqu were selected as the study subjects. And their demographic characteristics were described. The mean health score of residents after standardization was 81.59 ± 4.68. With the exception of gender, health scores differed between groups by age, education level, different occupations, marital status, and monthly income. The health status in Naqu, Tibet, was divided into two groups (entropy = 0.29, BLRT = 0.001, LMRT = 0.001) defined as the “good health group” and the “general health group.” A monthly income of more than ¥5000 adverse to good health in Naqu, Tibet.DiscussionSingle, well-educated young adults in Naqu, Tibet, have outstanding health. The vast majority of people in Tibet’s Naqu region were in good health. Furthermore, the population’s latent health status was divided into two classes, each with good dietary and living habits choices, low health knowledge, and a history of several clinical diseases. Univariate and multivariate logistic regression analysis showed that monthly income more than ¥5000 was an independent risk factor for poor health status.
Firearm use risk factors and access restriction among suicide decedents age 75 and older who disclosed their suicidal intent
Authors: Choi Namkee G. , Marti C. Nathan , Choi Bryan Y. 
Published: November 2023

Background and aimsA majority of older adult suicide decedents used firearms. In this study, we focused on suicide decedents age 75+ who disclosed their suicidal intent within a month of their injury/death to examine demographic and clinical characteristics associated with firearm use and firearm access restriction attempts by their family members.MethodsThe 2017–2019 U.S. National Violent Death Reporting System provided data (N = 1,734 suicidal intent disclosers; 1,476 males and 258 females; 21.4% of decedents age 75+). Generalized linear model (GLM) for a Poisson distribution with a log link was used to examine firearm use risk factors. Firearm access restriction attempts by decedents' family members were examined based on coroner/medical examiner and law enforcement (CME/LE) reports.ResultsNearly three quarters of disclosers disclosed their intent to family members, and 82.9% of males and 27.5% of females used firearms. GLM results showed males, non-Hispanic white people, and residents in the South and West regions had higher likelihood of firearm use. CME/LE reports of 140 out of 1,294 firearm decedents included narratives related to firearm restriction attempts or lack thereof. Firearm access restrictions were not attempted in 65 cases because family members did not take suicidal intent disclosure seriously or because decedents promised no self-harm. Partial or complete removal of firearms in 75 cases were not effective as decedents had hidden a firearm or purchased a new one. Others used different lethal methods.ImplicationsThe findings indicate a need for: (a) training family members of older adults who are at risk of suicide in effective means safety/access restriction and strategies to prevent means substitution; (b) more comprehensive legislative reforms reducing access to firearms by those at risk of suicide; and (c) more comfort and palliative care and counseling for psychosocial risk factors.
TWO-YEAR FLOWER CULTURES IN THE COLLECTION OF THE BOTANICAL GARDEN OF BILA TSERKVA NATIONAL AGRARIAN UNIVERSITY
Authors: Ishchuk L. 
Published: November 2023

The article presents the results of the analysis of the collection of two-year-old flowering ornamental plants in the Botanical garden of Bila Tserkva national agrarian university. It was established that the biennial collection includes 17 species belonging to 15 genera and 10 families. The largest number of species is represented by the family Brassicaceae Burnett. – Brassica oleracea L. var. Acephala DC., Erysimum perovskianum Fisch.hort., Hesperis matronalis L., Lunaria biennis L. The collection presents species that have not only decorative, but also medicinal, fodder, and tanning properties. Diditalis grandiflora contains poisonous glycosides. Alcea rosea has ethnographic significance and belongs to amulet plants.
The morphometric indicators of biennials by height and their flowering periods were analyzed. It was established that 41,2% of the collection of biennials of the Botanical Garden of the Bila Tserkva NAU belongs to low-growing species, medium-sized and tall plants are represented by the same number of species, which is 29,4% each. The largest number of species in the collection is represented by the group of summer-flowering biennials, 47,1%, late-spring-flowering ones make up 29,4%, and early-flowering ones – 23,5% of species.
Most biennials are cultivated in open ground to decorate flower beds, only a few to create seasonal bouquets and phytocompositions. Thanks to the plasticity of biennials, which is manifested in non-standard sowing dates, relative frost resistance and early spring and early summer flowering periods, biennials reduce the costs of growing seedlings and care for them after planting in a permanent place, provide an annual change in the design of flower beds and fill the flowerless periods of early spring and early summer. Biennials are suitable for creating borders, flower beds, rabatoks, lawns, carpets, ribbons, for decorating flowerbed groups and balconies, container culture. Tall species can be used as a background for the entire composition. Varietal diversity of Bellis perennis L., Brassica oleracea L. var. Acephala DC, Dianthus caryophyllus L. var. Grenadine hort, Dianthus barbatus L., Viola wittrockiana Gams. allows you to create monoculture flower beds with a wide color palette.
Training on the Implementation of Project Based Learning (PBL) Based on Literacy at the Elementery School Level
Authors: Saidatun Nafisah  , Budiarso Iwan 
Published: November 2023

The Kurikulum Merdeka is a curriculum concept launched by the Indonesian Ministry of Education, Culture, Research, and Technology (Kemendikbudristek) in 2021. Using this curriculum, schools can determine the right types and methods of learning for their students, as well as develop curricula that are more relevant to local and global needs. Overall, the PBL (Project Based Learning) method is very much in line with the concept of this curriculum because it provides the freedom, flexibility, and relevance needed in more effective and meaningful learning for students. PBL can also help teachers develop a more dynamic and flexible curriculum, as well as provide opportunities for students to be actively involved in the learning process. Improving literacy and numeracy is one of the main focuses in this curriculum. Literacy and numeracy are considered basic skills that every student must master, as these skills are important in living daily life, learning in the future, as well as participating in an increasingly complex society. It is because this curriculum is relatively new and not all schools can implement PBL, teachers need models of how to practice it. Thus, the researchers provide training on the application of PBL to elementary school teachers in cluster 04 Ciputat. In accordance with the researcher's field of expertise, the training on the application of PBL takes the realm of literacy.
Нормативно-правове забезпечення інноваційної діяльності в закладах загальної середньої освіти
Authors: Завалевський Юрій 
Published: November 2023

Стаття присвячена висвітленню питань державної політики в галузі освіти щодо сучасного стану нормативно-правового забезпечення інноваційної діяльності в закладах загальної середньої освіти та науково-практичного завдання обґрунтування рекомендацій із розвитку інноваційної діяльності в Україні.
Проаналізовано напрями вдосконалення нормативно-правового забезпечення щодо формування державної інноваційної політики, розвитку, стимулювання інноваційної діяльності в Україні, використання результатів наукових досліджень та нових конкурентоздатних розробок, аналіз понять «інновація», «інноваційна діяльність», «освітня інновація», «державна освітня політика».
Основну увагу закцентовано на пріоритетних напрямах інноваційної діяльності галузевого рівня у сфері освіти, як-от: iннoвaцiйних технологіях навчання; інтерактивних методах навчання з використанням iнфoрмaцiйних технологій; створенні кoмп’ютернo oрiєнтoвaних методів та систем навчання з різних предметів i навчальних дисциплін; упровадженні новітніх дидактичних моделей та технологій профільного навчання в закладах освіти; розробці програмових засобів навчального та наукового призначення, новітніх програм, підручників, посібників та методичних матеріалів нового покоління; необхідності впровадження інноваційних технологій у розвиток освітньої галузі з метою підвищення її ефективності.
Окреслено перспективи подальшого вдосконалення та модернізації державної політики в галузі освіти в Україні, що полягають у забезпеченні реального переходу до нової якості освіти й рівного доступу до неї; запровадженні інноваційних технологій навчання; приведенні у відповідність із європейськими стандартами наукового та науково-методичного забезпечення всіх ланок освіти; створенні ефективного механізму залучення та використання державних ресурсів для потреб освіти.
Pengaruh Transformational Leadership, Knowledge Sharing, Innovative Work Behaviour terhadap Organizational Performance pada Karyawan Perusahaan Ekspedisi di Jakarta
Authors: Hastari Lidya , Netania Emilisa  
Published: November 2023

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh Transformational Leadership ,Knowledge Sharing, Innovative Work Behaviour dan Organizatioal Performance pada karyawan perusahaan ekspedisi di Jakarta. Metode yang digunakan adalah Structural Equaion Model (SEM) dengan software AMOS versi 23 dengan jumlah 130 responden yaitu menyebarkan kuesioner melalui g-form yang diisi oleh karyawan perusahaan ekspedisi di Jakarta. Teknik pengolahan data yang digunakan pada penelitian ini yakni pengujian instrument seperti uji validitas dan realibitas serta Structural Equation Modeling (SEM) menggunakan SPSS dan AMOS. Hasil penelitian ini, Transformational Leadership berpengaruh positif tidak signifikan terhadap Organizational Performance, Transformational Leadership bepengaruh positif dan signifikan terhadap Knowledge Sharing, Transformational Leadership bepengaruh positif dan signifikan terhadap Innovative Work Behaviour, Knowledge Sharing berpengaruh positif dan signifikan terhadap Organizational Performance dan Innovative Work Behaviour berpengaruh positif dan signifikan terhadap Organizational Performance.
Pengaruh Kompetensi Auditor erhadap Kualitas Audit (Survey Pada Auditor yang Lulus Kuliah Ketika Masa Pandemik Covid-19 dan Bekerja di Kantor Akuntan Publik Berafiliasi Internasional)
Authors: Rendi Kusuma Natita  , Ali Rahman Reza Saputra  , Intan Pramesti Dewi  
Published: November 2023

Penelitian ini berupaya untuk mengetahui bagaimana Kompetensi Auditor mempengaruhi Kualitas Audit dan bagaimana Kualitas Audit dan Kompetensi berinteraksi. Populasinya adalah auditor dari perusahaan akuntan publik yang terkait atau berkolaborasi di seluruh dunia. Dengan menggunakan data primer yang bersumber dari kuesioner yang diajukan kepada respnden. Sementara sampel untuk diperoleh dengan menggunakan metode judgement sampling. Dengan data yang diolah sebanyak 80 data. Dihitung dengan menggunakan skala ukur ordinal dengan metode Skala Likert. Penelitian ini menujukkan hasil bahwa dan kompetensi audit secara simultan atau bersamasama berpengaruh signifikan secara positif terhadap Kompetensi audit.