bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Do sacrifício ao futuro promissor”: aluno de ensino médio nas representações sociais de professores
Authors: Machado Laeda Bezerra , Barbosa Evangelista Lucivania 
Published: December 2023

Este artigo tem como objetivo identificar a estrutura das representações sociais de “aluno de escola pública de ensino médio,” elaboradas por seus professores. Adotamos a Teoria das Representações Sociais (TRS), particularmente, abordagem estrutural dessas representações. Desenvolvemos um estudo de campo online com 71 professores da Rede Estadual de Pernambuco, os quais responderam a um questionário do tipo Google Doc e um Teste de Associação Livre de Palavras. As evocações, analisadas com auxílio do software Iramuteq, revelaram representações sociais de “aluno de escola pública de ensino médio” pautadas em dificuldades, decorrentes da situação de desigualdade social desses estudantes. Apesar disso, nessas evocações e justificativas dos professores, ganham relevância a capacidade de superação e a determinação dos alunos para enfrentar os obstáculos que lhes são impostos. Isto significa que, a despeito do sacrificio, nas representações sociais dos docentes, esses estudantes são desafiados, mas alcançam um futuro promissor. Os achados sugerem a necessidade de medidas capazes de equalizar as oportunidades e minimizar as desigualdades a fim de se construir as bases necessárias ao desenvolvimento social das juventudes que ingressam na escola de ensino médio.
Qual a origem do saber do auxiliar de classe? Estudo sobre o não lugar profissional
Authors: Jesus Livia Karen Figueredo  de , Gracia Ferreira Lucia 
Published: December 2023

Esta pesquisa objetivou conhecer qual a origem dos saberes mobilizados pelas pessoas que exercem a função de auxiliar de classe[1] e a influência destes na construção do “não lugar” profissional. Trata-se de uma investigação qualitativa, exploratória realizada nos municípios de Itapetinga e Amargosa, na Bahia, com pessoas que atuam nas turmas de Educação Infantil como auxiliar de classe. Foram realizadas no ano de 2020 entrevistas via plataformas digitais com sete colaboradores. Constatou-se que várias são as fontes da origem dos saberes dos auxiliares, sendo as histórias de vida, as experiências pessoais e cotidianas, a formação acadêmico-profissional e a própria prática laboral. Também que o binômio cuidar-educar é de responsabilidade do professor, legitimado historicamente e legalmente e que há muitas diferenças na função de professor e auxiliar. Assim, tudo isso tem apontado para a construção de um “não lugar” profissional dos auxiliares de classe.

[1] Optamos por utilizar a nomenclatura auxiliar de classe, mas a função também é nomeada por: auxiliar de desenvolvimento infantil, pajem, assistente de classe, monitora etc. A variação na nomenclatura ocorre de região para região, pois não há um consenso acerca da função.
The Impact of the COVID-19 Pandemic on Shelter Use Frequency and Experiences of Shelter Professionals in Finland: A Mixed-Method Study
Authors: Kaittila Anniina , Tuominen Jarno , Peltonen Joonas , Äärelä Eveliina , Husso Marita 
Published: December 2023

Purpose: The COVID-19 pandemic has been associated with an increased prevalence of domestic violence (DV). It has been proposed that the mitigation efforts—such as lockdown, social distancing, or stay-at-home orders—simultaneously increase the risk of DV while limiting the possibilities for seeking help. In this study, we explored the effects of the pandemic on shelter services.Method: The data consist of shelter use data and regular reports from 29 shelters in Finland. In a mixed-method study, we analyzed how shelter service use during the COVID-19 pandemic in Finland was predicted by the stringency of government actions. Furthermore, to gain additional depth on the topic, we carried out a qualitative analysis of the common issues raised by the staff in regular shelter reports.Results: We found the stringency of government actions—as measured by the comparative composite value of the Stringency Index—to causally predict shelter use during the pandemic. The major finding of our qualitative analysis is that the pandemic has affected shelters at three levels: victim, professional, and organization.Conclusion: As shelter reports indicate, the pandemic affected clients depending on how they perceive the pandemic, receive help, and the changes in their everyday lives at the shelter. At the professional level, COVID-19 affected the practices and content of work with clients, as well as the personal experience and well-being of staff. At the organizational level, there was a need to reconsider the preparedness and organization of work.
Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is l-Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine?
Authors: Erenburg Natalia , Perucca Emilio , Bechard Jeff , Dube Celine , Weishaupt Nina , Sherrington Robin , Bialer Meir 
Published: December 2023

Objectives: To investigate the comparative antiseizure activity of the l-enantiomers of d,l-fenfluramine and d,l-norfenfluramine and to evaluate the relationship between their concentration in plasma and brain and anticonvulsant activity.
Methods: d,l-Fenfluramine, d,l-norfenfluramine and their individual enantiomers were evaluated in the mouse maximal electroshock seizure (MES) test. d,l-Fenfluramine, d,l-norfenfluramine and their individual l-enantiomers were also assessed in the DBA/2 mouse audiogenic seizure model. All compounds were administered intraperitoneally. Brain and plasma concentrations of the test compounds in DBA/2 mice were quantified and correlated with anticonvulsant activity.
Results: In the MES test, fenfluramine, norfenfluramine and their enantiomers showed comparable anticonvulsant activity, with ED50 values between 5.1 and 14.8 mg/kg. In the audiogenic seizure model, l-norfenfluramine was 9 times more potent than d,l-fenfluramine and 15 times more potent than l-fenfluramine based on ED50 (1.2 vs 10.2 and 17.7 mg/kg, respectively). Brain concentrations of all compounds were about 20-fold higher than in plasma. Based on brain EC50 values, l-norfenfluramine was 7 times more potent than d,l-fenfluramine and 13 times more potent than l-fenfluramine (1940 vs 13,200 and 25,400 ng/g, respectively). EC50 values for metabolically formed d,l-norfenfluramine and l-norfenfluramine were similar to brain EC50 values of the same compounds administered as such, suggesting that, in the audiogenic seizure model, the metabolites were responsible for the antiseizure activity of the parent compounds.
Significance: Because of the evidence linking d-norfenfluramine to d,l-fenfluramine to cardiovascular and metabolic adverse effects, their l-enantiomers could potentially be safer follow-up compounds to d,l-fenfluramine. We found that in the models tested, l-fenfluramine and l-norfenfluramine were as active as the corresponding racemates. Based on the results in DBA/2 mice and other considerations, l-norfenfluramine appears to be a particularly attractive candidate for further evaluation as a novel, enantiomerically pure antiseizure medication.
A case of 17q12 deletion syndrome characterized by hypokalemia and hypomagnesemia
Authors: Ye Meng , Xu Jing , Zhang Zhi , He Juan , Xu Yi , Hu Ying , Wang Rui , Peng Nianchun , Zhang Miao , Xiao Banghui 
Published: December 2023

Abstract
Background
The 17q12 deletion syndrome is a rare autosomal dominant disease, the phenotypes of genetic diseases include abnormalities of the kidney, pancreas, brain, gastrointestinal tract, and reproductive tract. The manifestations of these diseases vary among individuals, and the clinical manifestations are different. Here we report a case of 17q12 deletion syndrome characterized by hypokalemia and hypomagnesemia to explore the diagnosis and treatment of 17q12 deletion syndrome.
Case presentation:
A 14-year-old young man was diagnosed with diabetes, further examination indicated that the patient had renal cysts, hepatic cysts, pancreatic atrophy, and mental retardation, in addition, the patient continued to have refractory hypokalemia and hypomagnesemia. A copy number heterozygous deletion of 1359.63kb was detected in the 17q12 region of the patient, the deletion interval was chr17:36385253 to 37744884, which contains 4 known Online Mendelian Inheritance in Man (OMIM) pathogenic genes, including PIGW, ZNHIT3, HNF1β, ACACA. Finally, Maturity-onset diabetes of the young type 5(MODY5) caused by HNF1β heterozygosity missing based on 17q12 deletion syndrome was confirmed.
Conclusion
The patient was diagnosed with diabetes combined with renal cysts, hepatic cysts, pancreatic atrophy, this suggested that we should consider the possibility of MODY5, in addition, the patient was complicated with intellectual disability, refractory hypomagnesemia and hypomagnesemia, these unexplained abnormal laboratory results and symptoms remind us of the possibility of screening for genetic syndromes. 17q12 deletion syndrome is an extremely rare genetic disorder affecting multiple organ systems, diabetic physicians should be alert to the possibility of MODY5 caused by 17q12 deletion syndrome.
Quantitative Analysis of Peri-intestinal Lymph Node Metastasis Using Indocyanine Green Fluorescence Imaging Technology
Authors: Lin Weiyang , Cui Wei , Li Qi , Sheng Jie , Zhao Yibing 
Published: December 2023

Abstract
Objective: This study evaluates the efficacy of indocyanine green fluorescence imaging (ICG-FI) compared to traditional nanocarbon dye in assessing peri-intestinal lymph node metastasis in colorectal cancer, a key factor in prognosis. The relationship between ICG-FI and histopathological outcomes in colon cancer patients is also explored.
Methods: A retrospective analysis was conducted on 30 colon cancer patients (May to October 2023), confirmed by surgical pathology. Tumors were marked with ICG or nanocarbon under colonoscopy 16-24 hours pre-surgery. Post-surgery, within 15 minutes, peri-intestinal lymph node fluorescence photography and hematoxylin and eosin staining assessed the cancer foci distribution. The study measured the correlation between cancer foci distribution, fluorescence intensity, and the area under the ROC curve (AUC).
Results: Out of 243 metastatic lymph nodes from 30 patients, metastases were found in 18 nodes from 9 patients. Dividing patients into metastasis and non-metastasis groups, significant differences were noted in tumor differentiation and staging (p<0.001). Fluorescence intensity strongly correlated with metastasis presence and proportion (AUC=0.931), while nanocarbon staining showed no significant correlation (p=0.81). All p-values were two-sided, with p<0.05 indicating significance.
Conclusion: Lymph nodes with malignant intestinal tumor metastasis displayed weaker ICG fluorescence compared to non-metastatic nodes. Combining ICG and nanocarbon staining techniques enhances intraoperative lymph node dissection and postoperative analysis, indicating their potential utility in colorectal cancer surgeries.
Pan-Cancer Analysis of the Prognostic and Immunological Role of HCCS: A Potential Target for Survival and Immunotherapy
Authors: Luo Ming , Deng Xinzhou , Jiang Shan , Lv Jiaqi , Wang Jincheng , Shi Mingliang , Feng Wei , Yan Yutao , Chai Jingjing , Luo Zhiguo 
Published: December 2023

Abstract

Background: Holocytochrome c synthase (HCCS) is a cytochrome c synthase that connects heme to cytochrome c. At present, the role of HCCS in tumors have not been reported.
Methods: The TIMER2, UALCAN, and HPA databases were also used to explore the expression level of HCCS, the GEPIA2 database was utilized to investigate the relationship between HCCS and the prognosis of patients with tumor, and the TISIDB website was utilized to study the relationship between HCCS and molecular subtypes and immune subtypes. R 3.6.2 software was used to construct ROC curves, DAVID database was used to perform GO and KEGG annotations.
Results: We find that HCCS is differentially expressed in 8 types of tumors, high expression of HCCS was correlated with poor prognosis in 5 types of tumors and good prognosis in 3 types of tumors. HCCS is differentially expressed in various molecular subtypes of 14 tumors and various immune subtypes of 19 tumors. HCCS has potential value for the diagnosis estimation of 12 types of tumors. HCCS may be involved in multiple processes, such as organelle fission, chromosome segregation and cell cycle. Silencing HCCS significantly inhibits LAUD cell proliferation, promotes G2M cell cycle arrest, and cisplatin induced cell apoptosis. HCCS is associated with the expression of PD-L1 and immunotherapeutic efficacy in several tumors.
Conclusions: This study suggests that HCCS is a biomarker for the diagnosis and prognosis estimation of various tumors, and it may also affect the efficacy of immunotherapy for tumors.
Aging-Related Immune Cell Phenotypes and Mortality in the Framingham Heart Study
Authors: Ragab Ahmed A.Y. , Doyle Margaret F. , Chen Jiachen , Fang Yuan , Lunetta Kathryn L. , Murabito Joanne M. 
Published: December 2023

Abstract
Background
The global increase in human life expectancy is evident. The total number of individuals aged 60 or above is anticipated to reach 2 billion by 2050. Aging, an inherently complex process, manifests prominently in the changes observed in the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Cell Phenotypes (ARIPs). Despite their significance, the connections between various ARIPs and mortality have not been thoroughly investigated. We prospectively investigated 16 different ARIPs using flow cytometry, namely, CD4/CD8 ratio, Granzyme B + CD8/Granyzme B + CD4, TN/TM = Tn / (Teff + Tem + Tcm) for TN/TM CD4 + and TN/TM CD8 + ratios, Th17/CD4 + Treg, Tc17/CD8 + Treg, Th17, Tc17, CD4 + Temra, CD8 + Temra, CD4 + CD25 + FoxP3+ (CD4 + Treg), CD8 + CD25 + FoxP3+ (CD8 + Treg) CD4 + CD27-, CD4 + CD28-CD27-, CD8 + CD27-, CD8 + CD28-CD27- and IL-6 in relation to survival outcome among dementia-free Framingham Heart Study (FHS) offspring cohort participants who attended the seventh exam (1998–2001).
Results
Among 996 participants (mean age 62 years, range 40 to 88 years, 52% female), the survival rate was 65% during 19 years of follow-up. For the model adjusting for age, sex, and cytomegalovirus (CMV) serostatus, higher CD4/CD8 and Tc17/CD8 + Treg ratios were significantly associated with lower all-cause mortality (HR:0.86 [0.76–0.96], 0.84 [0.74–0.94], respectively) and higher CD8 regulatory cell levels (CD8 + CD25 + FoxP3+) were associated with higher all-cause mortality (HR = 1.17, [1.03–1.32]). Higher IL-6 levels were associated with higher all-cause, cardiovascular, and non-cardiovascular mortality (HR = 1.43 [1.26–1.62], 1.70 [1.31–2.21], and 1.36 [1.18–1.57], respectively).
Hyperspectral Imaging Analysis for the Early Detection of Tomato Bacterial Leaf Spot Disease
Authors: Zhang Xuemei , Vinatzer Boris A. , Li Song 
Published: December 2023

Abstract

Recent advancements in hyperspectral imaging (HSI) for early disease detection have shown promising results, yet there is a lack of HSI data representing the responses of plants at different disease stages as measured by in planta pathogen density. To address this question, we used bacterial leaf spot of tomato as a model and collected hyperspectral images and in planta pathogen populations for seven days. Machine learning models were trained using data from leaf-level full spectra, vegetation index (VI), and pixel-level full spectra at four disease stages. The results suggest that HSI can detect tomato foliar disease at pre-symptomatic stages and differentiate bacterial disease spots from abiotic leaf spots. Using VI data as features for machine learning improved overall classification performance by 26-37% as compared to the direct use of raw data. Critical wavelength bands and VIs varied across disease progression stages, suggesting that pre-symptomatic disease detection relied more on changes in leaf water content and plant defense responses rather than changes in leaf pigments or internal structure, which are crucial during symptomatic stages. In conclusion, this study reveals the potential benefits of leaf structure segmentation and VI group pattern analysis in using HSI for the early detection of leaf diseases.
Preconception health and care policies, strategies and guidelines in the UK and Ireland: A scoping review
Authors: Cassinelli Emma H , McKinley Michelle C , Kent Lisa , Eastwood Kelly-Ann , Schoenaker Danielle AJM , Trew David , Stoikidou Theano , McGowan Laura 
Published: December 2023

Abstract
Background Preconception health has the potential to improve parental, pregnancy and infant outcomes. This scoping review aims to (1) provide an overview of the strategies, policies, guidelines, frameworks, and recommendations available in the UK and Ireland that address preconception health and care, identifying common approaches and health-influencing factors that are targeted; and (2) conduct an audit to explore the awareness and use of resources found in the scoping review amongst healthcare professionals, to validate and contextualise findings relevant to Northern Ireland.Methods Grey literature resources were identified through Google Advanced Search, NICE, OpenAire, ProQuest and relevant public health and government websites. Resources were included if published, reviewed, or updated between January 2011 and May 2022. Data were extracted into Excel and coded using NVivo. The review design included the involvement of the “Healthy Reproductive Years” Patient and Public Involvement and Engagement advisory panel.Results The searches identified 273 resources, and a subsequent audit with healthcare professionals in Northern Ireland revealed five additional preconception health-related resources. A wide range of resource types were identified, and preconception health was often not the only focus of the resources reviewed. Resources proposed approaches to improve preconception health and care, such as the need for improved awareness and access to care, preconceptual counselling, multidisciplinary collaborations, and the adoption of a life-course approach. Many behavioural (e.g., folic acid intake, smoking), biomedical (e.g., mental and physical health conditions), and environmental and social (e.g., deprivation) factors were identified and addressed in the resources reviewed. In particular, pre-existing physical health conditions were frequently mentioned, with fewer resources addressing psychological factors and mental health. Overall, there was a greater focus on women’s, rather than men’s, behaviours.Conclusions This scoping review synthesised existing resources available in the UK and Ireland to identify a wide range of common approaches and factors that influence preconception health and care. Efforts are needed to implement the identified resources (e.g., strategies, guidelines) to support people of childbearing age to access preconception care and optimise their preconception health.
Analysis of the effect of rainfall center location on the flash flood process at the small basin scale
Authors: Chen Guangzhao , Hou Jingming , Wang Tian , Gao Xujun , Yang Dangfeng , Li Tao 
Published: December 2023

AbstractWith the increasing frequency of extreme convective weather, the spatial–temporal variability of rainfall becomes more diversified. As a result of the insufficient quality of rainfall monitoring data in mountainous areas, the flash flood simulation usually does not consider the effect of the rainfall center location. In this work, the GPU Accelerated Surface Water Flow and Associated Transport hydrodynamic model is used to simulate the flash flood discharge process. The effect of the rainfall center location and the basin scale on the discharge process were analyzed based on simulated data. The results show that when the rainfall center is in the upstream and midstream basins, because of gravitational potential energy conversion, the total flood volume and the flood peak discharge increase to 2–10 times, and the peak time of flash flood caused by 100 mm rainfall amount can be advanced by up to 3,000 s compared to the 20 mm rainfall amount condition. The peak discharge and the delay of peak time increase with the increase of rain peak coefficient. In addition, the increase of the basin area enhances the effect of the rainfall center location. This work is helpful to quantify the effect of the rainfall center location, which can clarify the uncertainty of flash flood simulation caused by not considering the rainfall center factor.
Assessing the effectiveness of a residential-scale detention tank operated in a multi-objective approach using SWMM
Authors: Wang Shiping , Wang Jianlong , Xue Chonghua , Qiu Rongting , Sun Shi , Yang Zitong , Qiao Yuanhui 
Published: December 2023

Abstract
The volume capture ratio of annual rainfall (VCRAR) of low-impact development measures is significantly influenced by its operating characteristics, particularly for residential stormwater detention tanks (SWDTs). The multi-objective operation strategy of SWDTs, encompassing toilet flushing (TF), green space irrigation (GSI), combined TF and GSI (TF-GSI), and peak flow reduction (PFR) rate, were compared using a case study in Beijing based on the stormwater management model. The findings indicate that the VCRAR for TF, GSI, and TF-GSI rainwater harvesting targets was 89.05, 77.16, and 91.21%, respectively. The operating scheme and return periods have a significant impact on the PFR rate's effectiveness. When the return period was lower than 10 years, the SWDT does not reach its maximum storage capacity, and the PFR rate was increased with increasing the return period: the PFR rate was 71.47% when the design return period was 10 years. It will also produce the phenomena of water inrush, and the overflow volume will grow rapidly when the SWDT reaches its maximum storage capacity. Hence, the operation of SWDTs may be integrated with real-time control to optimize the VCRAR for rainwater reuse and flood migration, thereby enhancing the volume utilization efficiency of SWDTs.