bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on Nanocarrier-based Polyherbal Drug Delivery Systems for
Wound Healing
Authors: Rastogi Vaibhav , Porwal Mayur , Aalam Athar 
Published: February 2024

Background:
Nanotechnology-based polyherbal drug delivery systems are considered a
new and rapidly emerging area in the pharmaceutical field. They improved the drug loading capacity
or enhanced encapsulation efficiency of herbal drugs and thus improved permeation efficiency, accelerated
wound healing, promoted tissue remodelling, and reduced scarring.

Objective:
A wound on the skin is an injury of the skin tissues that arises due to a cut or damage and
also by an impact, blow, or other forces like a cut, surgery, chemical, heat, cold, friction, or illness
like leg ulcers or carcinomas. These wounds result in the loss of skin's protective function by the
removal of epithelium or connective tissues (i.e., muscle, bone, nerves). The four sequential but
overlapping phases of the typical wound healing process are hemostasis, inflammation, proliferation,
and remodeling. By encouraging the growth and movement of fibroblasts and keratinocytes, as well
as angiogenesis at the site of damage, it has been demonstrated that a polyherbal mixture composed
of plant extraction accelerates the lesion recovery process. Polyherbal formulations contain phytoconstituents
such as triterpenoids, flavonoids, coumarins, quinones, and carotenoids etc. All these
phytoconstituents are used for anti-inflammatory, anti-microbial, antioxidant, and lesion recovery. At
the same time, nanotechnology-based polyherbal formulation has the potential to overcome the limitations
of traditional polyherbal formulation in wound healing. Wounds are better managed by polyherbal
combination rather than an individual plant due to its synergism and fewer side effects. To
include these polyherbal components and deliver them to the wound site in a more focused and sustained
way, novel drug delivery systems are also being developed.

Conclusion:
This review discussed many nanotechnology-based polyherbal topical formulations for
efficient and faster wound healing and recovery. Nanotechnology-based polyherbal formulations
prove their success in promoting wound healing which is a unique approach to improving wound
care and development of healthy skin.
A Thorough Review of Deep Learning in Autism Spectrum Disorder
Detection: From Data to Diagnosis
Authors: Lamani Manjunath Ramanna , Pernabas Julian Benadit 
Published: February 2024

Background:
Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental
condition with significant heterogeneity in its clinical presentation. Timely and precise
identification of ASD is crucial for effective intervention and assistance. Recent advances in
deep learning techniques have shown promise in enhancing the accuracy of ASD detection.

Objective:
This comprehensive review aims to provide an overview of various deep learning
methods employed in detecting ASD, utilizing diverse neuroimaging modalities. We analyze a
range of studies that use resting-state functional Magnetic Resonance Imaging (rsfMRI), structural
MRI (sMRI), task-based fMRI (tfMRI), and electroencephalography (EEG). This paper
aims to assess the effectiveness of these techniques based on criteria such as accuracy, sensitivity,
specificity, and computational efficiency.

Methods:
We systematically review studies investigating ASD detection using deep learning
across different neuroimaging modalities. These studies utilize various preprocessing tools, atlases,
feature extraction techniques, and classification algorithms. The performance metrics of
interest include accuracy, sensitivity, specificity, precision, F1-score, recall, and area under the
curve (AUC).

Results:
The review covers a wide range of studies, each with its own dataset and methodology.
Notable findings include a study employing rsfMRI data from ABIDE that achieved an accuracy
of 80% using LeNet. Another study using rsfMRI data from ABIDE-II achieved an impressive
accuracy of 95.4% with the ASGCN deep learning model. Studies utilizing different
modalities, such as EEG and sMRI, also reported high accuracies ranging from 74% to 95%.

Conclusion:
Deep learning-based approaches for ASD detection have demonstrated significant
potential across multiple neuroimaging modalities. These methods offer a more objective and
data-driven approach to diagnosis, potentially reducing the subjectivity associated with clinical
evaluations. However, challenges remain, including the need for larger and more diverse datasets,
model interpretability, and clinical validation. The field of deep learning in ASD diagnosis
continues to evolve, holding promise for early and accurate identification of individuals
with ASD, which is crucial for timely intervention and support.
Assessing the Proficiency of Large Language Models on Funduscopic Disease Knowledge (Preprint)
Authors: Shao Yi , Wu Jun-Yi , Zeng Yan-Mei , Qian Xian-Zhe , Hong Qi , Hu Jin-Yu , Wei Hong , Zou Jie , Chen Cheng , Wang Xiao-Yu , Chen Xu 
Published: February 2024

BACKGROUND

Large language models (LLMs) have significantly transformed the field of natural language processing, with cutting-edge models like ChatGPT currently leading the way in medical AI.

OBJECTIVE

This study aimed to assess the performance of five distinct LLMs (GPT-3.5, ChatGPT-4, PaLM2, Claude 2, and SenseNova) in comparison to two human cohorts (a group of funduscopic disease experts and a group of ophthalmologists) on the specialized subject of funduscopic disease.

METHODS

Five distinct LLMs and two distinct human groups independently completed a 100-item funduscopic disease test. The performance of these entities was assessed by comparing their average scores, response stability, and answer confidence, thereby establishing a basis for evaluation.

RESULTS

Among all the LLMs, GPT-4 and PaLM2 exhibited the most substantial average correlation. Additionally, GPT-4 achieved the highest average score and demonstrated the utmost confidence during the exam. In comparison to human cohorts, GPT-4 exhibited comparable performance to ophthalmologists, albeit falling short of the expertise demonstrated by funduscopic disease specialists.

CONCLUSIONS

The study provided evidence of the exceptional performance of GPT-4 in the domain of funduscopic disease. With continued enhancements, validated LLMs have the potential to yield unforeseen advantages in enhancing healthcare for both patients and physicians.
Material ESG Alpha: A Fundamentals-Based Perspective
Authors: Ahn Byung Hyun , Patatoukas Panos N. , Skiadopoulos George S. 
Published: February 2024

ABSTRACT
Using SASB’s materiality framework, prior research finds alpha for the portfolio of firms with improving ratings on material ESG issues. We replicate this finding and provide a fundamentals-based perspective on why the materiality portfolio outperforms. Our basic premise is that changes in material ESG issues reflect fundamental firm characteristics. More financially established firms—firms with larger size, lower growth, and higher profitability relative to their sector—are more likely to not only create material strengths but also resolve material weaknesses in their ESG scoring. This fundamental link dictates that one should comprehensively control for fundamental determinants of stock returns before attributing portfolio outperformance to improving material ESG scores. Indeed, we find that the materiality portfolio does not generate alpha after we account for its exposure to profitability and growth factors. Our evidence underscores the issue of correlated omitted fundamental factors in the debate of ESG alpha.
Data Availability: Data are available from the sources cited in the text.
JEL Classifications: G11; G12; G14; M14; M41; Q51.
Cemetery at Luzino – the easternmost located site of the Dębczyno Group in Poland (Pomerania)
Authors: Piotrowska Magdalena , Żychliński Daniel 
Published: February 2024

Luzino burial ground is the easternmost site of the Dębczyno group, located in Wejherowo county, in the northern Polish province of Pomerania. The cemetery occupied the summit of a slightly elevated terrain ridge. The remains of 20 graves, most probably only skeletal burials, were recorded, in which, apart from one case, no bone material survived. Grave goods were recorded in five of them. In four graves, small-sized hand-made vessels were recorded whose state of preservation allowed their reconstruction, while in one burial an elaborate necklace of beads (glass and amber, see below), a brooch and probably a belt buckle were discovered. The materials found at the Luzino site should be associated with the late stages of Migration Period. The burials with grave goods, however, show mainly links to the Elbe circle, while Scandinavian influences are lacking in the mobile materials.
ENFOQUE ESTRATÉGICO DE LOS RECURSOS RENOVABLES PARA GENERACIÓN ELÉCTRICA EN EL ECUADOR
Authors: Guarderas Galo , León Vasquez Rubén 
Published: February 2024

En el presente estudio, se realiza un análisis acerca de la implicación del control estratégico de los recursos primarios para generación de energías en forma general, principalmente aborda el estudio en función de los recursos no hídricos: fotovoltaica, eólica, geotérmica y otras similares. Basados en los recientes hechos que la humanidad está soportando como la pandemia y el conflicto bélico entre Rusia y Ucrania, se ha abordado la disyuntiva de la importancia de que los recursos primarios energéticos estén bajo el control estratégico del estado únicamente, o que sean administrados bajo otros modelos, como podrían ser: asociaciones público- privadas, privatizarlas o concesionarlas. El artículo está estructurado de la siguiente manera: la sección I cubre una introducción de la situación actual de las energías renovables en el Ecuador, en la sección II presentamos una perspectiva de generación de energía eléctrica mediante recursos renovables, en la sección III se pone en evidencia el problema del control estratégico de la generación de energía eléctrica y en base a ella proponemos la posible estructura de generación eléctrica, y finalmente en la sección IV conclusiones y trabajos futuros.

Palabras clave: Administración; estrategia; generación; gestión; renovables, securitización
Treatment of lidocaine-refractory ventricular tachycardia using procainamide in an anesthetized horse
Authors: Fernandez-Barrientos Manuel A. , Flynn Harriet , Ratliff Bridget , Kilcoyne Isabelle 
Published: February 2024

Abstract

OBJECTIVE
To highlight the use of procainamide as a potential alternative treatment modality in cases of ventricular tachycardia that are refractory to lidocaine and magnesium sulfate.

ANIMAL
1 adult horse weighing 380 kg.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES
A 25-year-old Arabian gelding presented with severe colic signs. Due to persistent pain, it was elected to carry out an exploratory laparotomy. During the procedure a diagnosis of severe, unstable ventricular tachycardia was made based on the ECG findings, with an initial heart rate of 195 beats per minute and severe hypotension.

TREATMENT AND OUTCOME
Initial treatment consisted of discontinuing dobutamine and the administration of a 2 mg/kg IV lidocaine bolus followed by a continuous rate infusion at 50 μg/kg/min. Twenty grams magnesium sulfate (5 mg/kg) was administered IV in 1 L of lactated Ringer solution as a slow bolus over 30 minutes. Ventricular tachycardia persisted with poor peripheral pulses, a severely dampened arterial waveform, and a MAP of 30 to 45 mm Hg. Two milligrams/kg IV procainamide was administered over 3 minutes, 3 separate times, at 5-minute intervals. Immediately following the third dose sinus rhythm was detected on the ECG, the arterial waveform improved, and MAP increased to 85 mm Hg.

CLINICAL RELEVANCE
Ventricular tachycardia is a rare but potentially life-threatening complication in horses undergoing general anesthesia. The potential of this arrhythmia to progress to ventricular fibrillation is of grave concern, as the option to attempt to externally defibrillate horses back to normal sinus rhythm does not exist. This case highlights procainamide as a potential option for cases of ventricular tachycardia that are refractory to more standard treatment modalities.
Rabies postexposure prophylaxis protocol option for unvaccinated domestic animals, Texas: 2010–2019
Authors: Wilson Pamela J. , Hunt Patrick R. , Fonken Eric P. 
Published: February 2024

Abstract

OBJECTIVE
To assess data on rabies postexposure prophylaxis (PEP) in domestic animals following Texas’ protocol and to describe preexposure and postexposure vaccination failures from 2010 through 2019.

ANIMALS
1,218 unvaccinated animals that received PEP, 925 unvaccinated animals that were euthanatized instead of receiving PEP, and 3 preexposure vaccinated dogs that developed rabies.

METHODS
Zoonotic incident reports from 2010 through 2019 were reviewed for information regarding animals with no known rabies vaccination that received PEP or were euthanatized in accordance with state protocol after exposure to a laboratory-confirmed rabid animal; reports were also reviewed for any preexposure and postexposure vaccination failures. The state-required PEP protocol was to immediately vaccinate the animal against rabies, confine the animal for 90 days, and administer booster vaccines during the third and eighth weeks of the confinement period.

RESULTS
From 2010 through 2019, 1,218 exposed animals received PEP; 99.8% did not develop rabies. Three failures were recorded, all in animals < 12 weeks of age when PEP was initiated. Additionally, 925 exposed animals were euthanatized instead of receiving PEP. One true preexposure vaccination failure was recorded.

CLINICAL RELEVANCE
The Texas PEP protocol was used during the 10-year period. Results indicated that this protocol is a viable option for unvaccinated domestic animals exposed to rabies. Alternative protocols warrant additional consideration.
High School Teachers’ Work Motivation: A Mixed Research Method
Authors: Özcan Mehmet 
Published: February 2024

Abstract
This study aims to reveal the work motivation of high school teachers and was carried out with an explanatory sequential design, which is one of the mixed research methods. There were 284 participants in the quantitative stage and 15 participants in the qualitative stage of the study. At the quantitative stage, a work motivation scale was used, while in the qualitative part, an interview form consisting of 4 questions was used. As independent variables, gender, branch, professional experience and education level were used. As a result of the analysis, high school teachers’ work motivation levels do not significantly differ in terms of educational level and professional experience but significantly differ in terms of gender and branch. The mean score of high school teachers’ team cohesion, job integration, commitment to the institution and personal development level are found high. The Kaiser-Meyer-Olkin (KMO) value of the work motivation scale used in the quantitative part of the study was found as .892 and the Bartlett Test as 1490.185. As a result of analysis teachers’ work motivations rise with peace, efficiency, academic success, balanced relationships, love of the job, communication, organizational belonging, organizational management, organizational culture, in-service training, self-confidence, research and experience.
Rights of Nature? Shifting Patterns in Environmental Constitutionalism1
Authors: Jędrzejowska-Schiffauer Izabela , Schiffauer Peter 
Published: February 2024

Abstract
The article outlines improvements in environment and climate protection in constitutional law and practice all over the world, examining constitutional texts, case law and constitution-like legislation. A legal standing of individuals to defend the environment is increasingly added to programmatic provisions addressed to public authorities. In some cases Nature is granted legal personality. The latter innovation connects well to traditions established in the global South, where it was introduced first, but not so to legal systems of the Occident, where it was recently introduced for the first time. In strictly legal terms the effects of this innovation can also be achieved by classical legal instruments, while its metaphoric dimension promises a change in people’s attitudes towards nature. A second innovation concerns the shift from an anthropocentric to a bio-cultural or ecocentric approach. This would render constitutional law on the environment fully effective and convey a substantive meaning to a personalised concept of Nature. Such a development is, however, uncertain. The rights of Nature risk remaining trapped in anthropocentric categories of subject and object of law when transposed to Occidental legal thinking and practice. To avoid such inadvertent contradictions, the article pleads for reconciling both approaches by seeking more equilibrium in the Human-Nature relationship.
Change in the Jurisprudential Line Concerning the Location of Photovoltaic Installations on the Basis of Decisions on Development Conditions and Change in the Rules of Locating Photovoltaic Installations on the Basis of Local Plans
Authors: Kruś Maciej 
Published: February 2024

Abstract
The article discusses the changes in court jurisprudence regarding the issuance of decisions on development conditions in locating photovoltaic installations. The second important subject of the article is legal changes related to the location of these installations based on the development plan. In both cases, the changes aimed to facilitate the construction of photovoltaic installations. This is a very good direction because it is necessary to develop non-emission energy sources. In addition, the development of photovoltaic installations can be combined with further agricultural use of land.
Peculiarities of establishing the fact of recognition of paternity under the legislation of the Russian Federation
Authors: Purge Anna Rolandovna 
Published: February 2024

The subject of the study is the norms of Russian family legislation regulating relations related to the procedure for establishing the fact of recognition of paternity. The object of this study is family and procedural relations arising in connection with the establishment of the fact of recognition of paternity. The concept of "illegitimate children" is one of the oldest in the history of law. His appearance is associated with the strengthening of the monogamous family. The universal principle of equality, declared for the first time in Soviet law, demanded the equalization of illegitimate children, including in rights with children born in marriage. However, until the very end of the action of the CPC of the RSFSR, such a fact as the recognition of paternity was absent from it. Since the procedural features of the proceedings to establish the fact of recognition of paternity could not be reflected in the IC of the Russian Federation – due to the material nature of the regulated relations, for the purpose of uniform application of civil procedure legislation regulating the procedure for considering cases of special proceedings, the fact of recognition of paternity was for the first time included in the list of facts of legal significance established by the CPC of the Russian Federation. Thus, the date of occurrence in the Russian civil procedure legislation of the institution of establishing the fact of recognition of paternity is (if we do not accept the judicial practice that created it) the date of entry into force of the Civil Procedure Code of the Russian Federation in 2002. In the course of the work, general scientific and special methods of cognition were used: comparative legal in the analysis of new and previously existing family legal norms, as well as the formal legal method. It cannot be said that the procedural rules for establishing paternity have not been the object of research in Russian jurisprudence. However, issues of non–search proceedings, issues of establishing the fact of recognition of paternity - attention in these studies has not been adequately paid, although procedural features and the presence of a considerable number of problematic aspects of the consideration of this category of cases are beyond doubt. So far, this institution has not been significantly demanded by judicial practice, but a special military operation implies an increase in its relevance, since in the absence of the serviceman himself, the court requires any evidence of the fact that he recognizes paternity in relation to the child. Currently, this status is particularly important for receiving social benefits that the State has guaranteed to members of military families.
Television documentaries of the People's Republic of China (using the example of CCTV)
Authors: Chen Xue 
Published: February 2024

Television documentaries in China, especially on the largest national television channel China Central Television (CCTV), is a unique object of research reflecting a wide range of socio-cultural, political and technological aspects of the development of Chinese society. CCTV is not only an important information and entertainment source, but also a powerful tool for influencing public opinion, forming national identity and promoting public policy. The analysis of the history of the development of television documentaries in China reflects the influence of political events and socio-cultural changes on its evolution. Starting from the early stages of the development of Chinese television, when it served as a tool of state propaganda, and up to the present, when new topics and genres appeared, the study will help to understand how television documentaries have become an important element of cultural heritage and a means of public communication. The organizational structure of CCTV, as a key player in the Chinese media space, plays a significant role in shaping content and influencing public opinion. The method or methodology of the study. The methodology of this study is devoted to a comprehensive analysis of television documentaries in China with an in-depth examination of the example of China Central Television (CCTV). This methodology is based on a comprehensive study of historical, cultural, political and technological aspects of the development of television documentaries in China. The study of television documentaries in China, with a focus on the example of China Central Television (CCTV), provides a significant contribution to understanding the diverse aspects of the formation and impact of this media format in the context of Chinese culture and society. The scientific novelty of this study is manifested in several key aspects. Firstly, an extensive historical analysis reveals the evolution of television documentaries in China over various periods, emphasizing the influence of political changes and socio-cultural factors on its development. Secondly, the structural analysis of CCTV reveals the organizational mechanisms that form documentary projects. Considering the interaction between the structure of the channel and the content of programs makes it possible to understand what factors influence the formation and implementation of documentary initiatives, as well as how these factors are related to public policy. The third important achievement is the thematic analysis, which highlights the main themes and directions of documentary on CCTV.