bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nano‐Sized Cobalt Cluster Films: Structure and Functionality
Authors: Palasantzas G. , Koch S. A. , Vystavel T. , De Hosson J. Th. M. 
Published: February 2005

AbstractAn exchange interaction between magnetic clusters at ambient temperature leads to a correlated super‐spin glass state as a result of frustration between inter‐particle exchange interaction and randomly oriented intra‐particle anisotropy. In addition, after cluster oxidation a core‐shell system appears that causes an exchange bias field at cryogenic temperatures due to ferromagnetic‐antiferromagnetic coupling, which is also stabilized by cluster interactions.
Self‐Assembly of the Mesoporous Electrode Material Li3Fe2(PO4)3 Using a Cationic Surfactant as the Template.
Authors: Zhu Shenmin , Zhou Haoshen , Miyoshi Toshikazu , Hibino Mitsuhiro , Honma Itaru , Ichihara Masaki 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalytic Action of Cobalt and Nickel Complexes of Porphyrins and Their Polymer‐Bound Derivatives in Epoxidation Reaction of Styrene.
Authors: Nikolaeva O. I. , Kurek S. S. , Ageeva T. A. , Koifman O. I. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Simple and Efficient Radical Reduction Using Water‐Soluble Radical Initiator and Hypophosphorous Acid in Aqueous Alcohol.
Authors: Nambu Hisanori , Alinejad Anahita Hessamian , Hata Kayoko , Fujioka Hiromichi , Kita Yasuyuki 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Chelation‐Assisted Hydrative Dimerization of 1‐Alkyne Forming α,β‐Enones by an Rh(I) Catalyst.
Authors: Park Young Jun , Kwon Bong‐Il , Ahn Jeong‐Ae , Lee Hyuk , Jun Chul‐Ho 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Potassium Dodecatungstocobaltate Trihydrate (K5CoW12O40×3H2O) as an Efficient Catalyst for Aminolysis of Epoxides.
Authors: Rafiee E. , Tangestaninejad Shahram , Habibi M. H. , Mirkhani V. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Practical Procedure for the Synthesis of 3‐((E)‐5‐(2,3,4,5‐Tetramethoxy‐6‐methylphenyl)‐3‐methylpent‐3‐enyl) ‐2,2‐dimethyloxirane.
Authors: Chu Yong , Kuang Yunyan , Dai Huifang , Lu Liang , Chen Fen‐er 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Electrochemical Dimerization of Phenacyl Bromides N‐Acylhydrazones — A New Way to 1‐N‐Acylamino‐2,5‐diaryl‐pyrroles.
Authors: Batanero Belen , Elinson Michail N. , Barba Fructuoso 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Baylis—Hillman Reaction Assisted Synthesis of Substituted 5,8‐Dihydroisoxazolo[4,5‐c]azepin‐4‐ones: A Novel Isoxazole‐Annulated Heterocycle.
Authors: Batra Sanjay , Roy Amrendra K. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Origins of “on—off” Fluorescent Behavior of 8‐Hydroxyquinoline Containing Chemosensors.
Authors: Bronson R. Todd , Montalti Marco , Prodi Luca , Zaccheroni Nelsi , Lamb Randy D. , Dalley N. Kent , Izatt Reed M. , Bradshaw Jerald S. , Savage Paul B. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of New Dipyridylphenylaminosiloles for Highly Emissive Organic Electroluminescent Devices.
Authors: Aubouy Laurent , Gerbier Philippe , Huby Nolwenn , Wantz Guillaume , Vignau Laurence , Hirsch Lionel , Janot Jean‐Marc 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and in vitro Photodynamic Activity of New Hexadeca‐Carboxy Phthalocyanines.
Authors: Choi Chi‐Fung , Tsang Po‐Ting , Huang Jian‐Dong , Chan Elaine Y. M. , Ko Wing‐Hung , Fong Wing‐Ping , Ng Dennis K. P. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Adenylosuccinate Lyase Deficiency — First British Case
Authors: Marinaki A. M. , Champion M. , Kurian M. A. , Simmonds H. A. , Marie S. , Vincent M. F. , van den Berghe G. , Duley J. A. , Fairbanks L. D. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cyclase and Phosphodiesterase Activity on Pre‐T Lymphoid Human Cells, Treated with Dimethyl Sulfoxide (DMSO)
Authors: Di Pietrantonio F. , Di Matteo E. , Di Nicola M. , Trubiani O. , Di Primio R. , Serra E. , Spoto G. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
6‐[2‐(Phosphonomethoxy)alkoxy]‐2,4‐diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity
Authors: Balzarini J. , Pannecouque C. , Naesens L. , Andrei G. , Snoeck R. , De Clercq E. , Hockova D. , Holy A. 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Revised Chirality of the Acyl Group of 8′‐O‐(3‐Hydroxy‐3‐methylglutaryl)‐8′‐hydroxyabscisic Acid.
Authors: Kamo Tsunashi , Hirai Nobuhiro , Matsumoto Chiaki , Ohigashi Hajime , Hirota Mitsuru 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Antifungal Polyene Amides from the Myxobacterium Cystobacter fuscus: Isolation, Antifungal Activity and Absolute Structure Determination
Authors: Kundim Bangi A. , Itou Yu , Sakagami Youji , Fudou Ryosuke , Yamanaka Shigeru , Ojika Makoto 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Fragmentation‐Related Phosphinylation and Phosphonylation of Nucleophiles Utilizing the Bridging P‐Unit of 2‐Phosphabicyclo[2.2.2]oct‐5‐ene Derivatives
Authors: Keglevich Gyoergy , Szelke Helga , Kovacs Janos 
Published: February 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Volatile constituents of Salvia spinosa L. from Iran
Authors: Nik Z. Baher , Mirza M. 
Published: February 2005

AbstractThe essential oil, isolated by steam distillation from the aerial parts of Salvia spinosa L. growing wild in Iran was analysed by GC and GC–MS. Among 29 identiﬁed compounds representing about 99.5% of the oil, the major components were (E)‐β‐ocimene (12.3%), β‐caryophyllene (10.2%) and isopentyl isovalerate (9.5%). Copyright © 2004 John Wiley & Sons, Ltd.
Modelling of inflow boundary conditions for image‐based simulation of cerebrovascular flow
Authors: Oshima Marie , Sakai Hiroyuki , Torii Ryo 
Published: February 2005

AbstractThe goals of this study were to model the secondary flow components of inflow boundary conditions and examine the effects of inflow boundary conditions on cerebral haemodynamics. Finite element simulations were conducted for the curved pipe model and the results were compared with PIV measurements. The vortex structures of secondary flow were modelled in terms of the Dean number, which is a function of curvature and the Reynolds number. The modelled secondary flow was superimposed on the axial velocity profile obtained by ultrasound as the inflow boundary condition. The image‐based simulation was performed for an aneurysm of the middle cerebral artery using the modelled inflow boundary conditions. Results of inflow models with and without secondary flow are compared and show differences in flow patterns and wall shear stress distributions depending on the inflow model. Copyright © 2005 John Wiley & Sons, Ltd.
Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum
Authors: Lee Jae‐Chul , Cho Geum‐Sil , Kim Hye Jin , Lim Ji‐Hye , Oh Yu‐Kyoung , Nam Wonwoo , Chung Jang‐Hyun , Kim Won‐Ki 
Published: February 2005

AbstractIn cerebral ischemic insults, activated inflammatory cells such as microglia and macrophages may be implicated in the pattern and degree of ischemic injury by producing various bioactive mediators. In the present study, we provide the evidence that activated microglia/macrophages accelerate cerebral ischemic injury by overexpression of inducible nitric oxide synthase (iNOS). To activate microglia/macrophages, a potent inflammation inducer lipopolysaccharide (LPS, 5 μg/5 μl) was microinjected into rat corpus callosum. Isolectin B4‐positive microglia/macrophages were abundantly observed in ipsilateral hemisphere at 1 day after LPS injection. RT‐PCR showed that LPS injection induced iNOS mRNA expression mostly in microglia/macrophages, peaking in intensity at 15 h after LPS injection. While ischemic injury was little evoked in control rats by 2‐h middle cerebral artery occlusion (MCAO) followed by 3‐h reperfusion, it was markedly increased in rats pre‐injected with LPS 1 day before MCAO. However, no significant difference between control and LPS‐pretreated groups was observed after 24‐h reperfusion. The increased ischemic injury in LPS‐treated rats was well correlated with iNOS level expressed over 3 orders of magnitude than in LPS‐untreated rats. Immunohistochemical studies showed that iNOS‐ and nitrotyrosine (a peroxynitrite marker)‐positive cells were prominent throughout the infarct area. NOS inhibitors aminoguanidine or NG‐nitro‐L‐arginine, simultaneously injected with LPS, reduced the iNOS immunoreactivity and infarct volume, especially in penumbra regions. Total glutathione levels in ischemic regions were decreased more in LPS pre‐injected rats than in control ones. Further defining the role of NO in cerebral ischemic insults would provide the rationale for new therapeutic strategies based on modulation of microglial and macrophageal NO production in the brain. © 2005 Wiley‐Liss, Inc.
Mutation analysis of p53, K‐ras, and BRAF genes in colorectal cancer progression
Authors: Calistri Daniele , Rengucci Claudia , Seymour Ian , Lattuneddu Arturo , Polifemo Anna maria , Monti Franco , Saragoni Luca , Amadori Dino 
Published: February 2005

AbstractGene mutations in APC, K‐ras, and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K‐ras and p53 mutations rarely co‐exist in the same tumor, indicating that these alterations do not represent a synergistic evolutionary pathway. Moreover, an inverse relation between K‐ras gene activation and BRAF mutations has been demonstrated, suggesting alternative pathways for colorectal cancer transformation. To reconstruct the chronological modulation of these gene mutations during cell transformation and colorectal cancer progression, mutations of p53, K‐ras, and BRAF genes were analyzed by Single Strand Conformation Polymorphism (SSCP) or sequencing analysis in 100 colorectal cancer samples, evenly distributed among different Dukes' stages. We found mutations in p53, K‐ras, and BRAF genes in 35%, 30%, and 4% of tumors, respectively, and observed a minimal or no co‐presence of these gene alterations. Moreover, the frequency of molecular p53 mutations increased as tumor stage increased, suggesting an important role for this gene in the progression of colorectal cancer. Conversely, K‐ras or BRAF genes were not related to tumor stage or location. These data seem to indicate the absence of a co‐presence of the genes, highlighting the possibility of multiple pathways for colorectal tumor progression. Moreover, mutations in p53, K‐ras, and BRAF are not present in about one‐third of colorectal cancers and therefore other gene mutations need to be investigated to better understand molecular mechanisms at the basis of cell transformation and the progression of colorectal cancer. © 2005 Wiley‐Liss, Inc.
Interaction and functional interplay between endoglin and ALK‐1, two components of the endothelial transforming growth factor‐β receptor complex
Authors: Blanco Francisco J. , Santibanez Juan F. , Guerrero‐Esteo Mercedes , Langa Carmen , Vary Calvin P.H. , Bernabeu Carmelo 
Published: February 2005

AbstractTransforming growth factor‐β (TGF‐β) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK‐1 are components of the TGF‐β receptor complex, predominantly expressed in endothelial cells, and mutations in either endoglin or ALK‐1 genes are responsible for the vascular dysplasia known as hereditary hemorrhagic telangiectasia. Here we find that the extracellular and cytoplasmic domains of the auxiliary TGF‐β receptor endoglin interact with ALK‐1 (a type I TGF‐β receptor). In addition, endoglin potentiates TGF‐β/ALK1 signaling, with the extracellular domain of endoglin contributing to this functional cooperation between endoglin and ALK‐1. By contrast, endoglin appears to interfere with TGF‐β/ALK‐5 signaling. These results suggest that the functional association of endoglin with ALK‐1 is critical for the endothelial responses to TGF‐β. © 2005 Wiley‐Liss, Inc.
Enhanced intracellular uptake and inhibition of NF‐κB activation by decoy oligonucleotide released from PLGA microspheres
Authors: De Rosa Giuseppe , Maiuri Maria Chiara , Ungaro Francesca , De Stefano Daniela , Quaglia Fabiana , La Rotonda Maria Immacolata , Carnuccio Rosa 
Published: February 2005

AbstractBackgroundNuclear factor‐κB (NF‐κB) transcription factor regulates the expression of genes involved in immune response and inflammation. NF‐κB activity can be efficiently inhibited by double‐stranded oligodeoxynucleotides (ODNs). In the present study, we investigated the potential of poly(DL‐lactic‐co‐glycolic acid) (PLGA) microspheres as delivery system for an ODN against NF‐κB in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS).MethodsMicrospheres encapsulating ODN were prepared by the multiple emulsion/solvent evaporation technique and characterised in terms of size, morphology, encapsulation efficiency and in vitro release profile. In vitro uptake after 4 h and activity of ODN released from microspheres were evaluated in RAW 264.7 macrophages stimulated with LPS for 24, 48 and 72 h.ResultsWe prepared microspheres with a high encapsulation efficiency showing a very slow and almost constant in vitro release of ODN for up to 1 month. ODN slowly released from microspheres translocated better into LPS‐stimulated cells as compared with naked ODN. Incubation of cells with ODN‐encapsulating microspheres resulted in a decrease of tumor necrosis factor‐alpha (TNF‐α) and nitrite production, inducible nitric oxide synthase (iNOS) protein expression, as well as NF‐κB/DNA‐binding activity. Similar results were obtained with naked ODN only at about 80 times higher concentrations.ConclusionsOur results suggest that PLGA microspheres could be a useful tool to improve pharmacokinetics of a ODN decoy to NF‐κB and may represent a promising strategy to effectively inhibit the transcriptional activity of NF‐κB in inflammatory process. Copyright © 2005 John Wiley & Sons, Ltd.
Welfare, performance and meat quality of fattening pigs in alternative housing and management systems: a review
Authors: Millet Sam , Moons Christel PH , Van Oeckel Monique J , Janssens Geert PJ 
Published: February 2005

AbstractConventional husbandry systems for pork production are scrutinized by members of the general public as well as the scientific community. As a response, alternative forms of pig production, such as outdoor housing, organic farming and environmental enrichment are gaining interest. The question arises whether these production systems are indeed able to improve the welfare and health status of the animals, and whether these production systems alter production characteristics and meat or carcass traits. Measures of poor welfare have been described, but evaluating overall welfare is difficult. Certain parameters of alternative housing will improve welfare in some ways but, simultaneously, other welfare problems are inflated, and the weighting of each of these problems is very subjective. Alternative housing systems allow pigs to display species‐specific behaviour and decrease the occurrence of abnormal behaviours by acting on several parameters: indoor versus outdoor housing, floor space/density, floor type, and provision of bedding or other types of environmental enrichment. Evaluating alternative housing systems should be done by looking at all the welfare‐improving factors and the cost of alleviating welfare‐decreasing problems in a given production system. Data in the literature on growth, meat and carcass traits in alternative production systems, are inconsistent, indicating that other factors can play an important role. However, as equal, or in some cases even better, performance can be attained in certain production systems that meet concerns of animal welfare scientists and members of the general public, alternative production forms may be considered preferable. Copyright © 2005 Society of Chemical Industry
Selective removal of tannins from medicinal plant extracts using a collagen fiber adsorbent
Authors: Liao Xue‐Pin , Shi Bi 
Published: February 2005

AbstractA novel adsorbent, used for the selective removal of tannins from medicinal plant extracts, was prepared from bovine skin collagen fiber. Some typical active constituents of medicinal plants were selected as probe molecules to investigate the adsorption selectivity of the collagen fiber adsorbent to tannins. In batch adsorption experiments, the extent of adsorption of condensed tannins, including larch tannin, black wattle tannin and bayberry tannin, was 100%. The extent of adsorption of tannic acid and the hydrolyzable tannins was also 100%. In contrast, for the most active constituents of medicinal plants, their amounts adsorbed by collagen fiber adsorbent were limited. For procyanidin, the common active constituents in medicinal plant extracts, its extent of adsorption was also low, although it has a similar basic structure to condensed tannins. In comparison with traditionally used polyamide adsorbent, the collagen fiber adsorbent exhibited an obvious advantage in adsorption selectivity over tannins. Therefore, this study provides a novel and effective method for selective removal of tannins from medicinal plant extracts. Copyright © 2005 Society of Chemical Industry
Effect of storage temperatures and time on shelf‐life of sliced and modified atmosphere packaged Pastırma, a dried meat product, produced from beef
Authors: Aksu Muhammet İrfan , Kaya Mükerrem 
Published: February 2005

AbstractThe effects of modified atmosphere on some physical, chemical and microbiological properties of sliced pastırma made from beef Longissimus dorsi muscle were investigated. Sliced‐pastırma samples (moisture 43.65 ± 0.15%, pH 5.71 ± 0.02) were stored in modified atmosphere packages (50% N2 + 50% CO2) at 4 and 10 °C for 150 days. The storage period had a significant effect (p < 0.01) on moisture, pH, thiobarbituric acid reactive substances, free fatty acid, non‐protein nitrogen, water‐soluble nitrogen, colour values and total aerobic bacteria, lactic acid bacteria and Micrococcus/Staphylococcus counts. The storage temperatures (4 and 10 °C) also had a significant effect (p < 0.01) on moisture, pH, thiobarbituric acid reactive subctances, free fatty acid, water soluble nitrogen, a* values, total aerobic bacteria lactic acid bacteria, and Micrococcus/Staphylococcus counts. It was determined that the storage period × the storage temperature interactions had a significant (p < 0.01) effect on the values of pH, a* and the counts of total aerobic bacteria, lactic acid bacteria, Micrococcus/Staphylococcus. It was also observed that the yeast and mold count was the highest in the first storage period and decreased throughout storage. Enterobacteriaceae count was also below the detectable level (<2.00 cfu g−1) throughout the storage period. Copyright © 2005 Society of Chemical Industry
Ewing sarcoma as a second malignant neoplasm after acute lymphoblastic leukemia
Authors: Kim Grace E. , Beach Barbara , Gastier‐Foster Julie M. , Murata‐Collins Joyce L. , Rowland Jon M. , O'Donnell Richard J. , Goldsby Robert E. 
Published: February 2005

AbstractSecond malignant neoplasms (SMNs) are being increasingly recognized. This report describes a case of a 7‐year‐old girl with a history of acute lymphoblastic leukemia (ALL) who presented with a mass in her humerus that was diagnosed as Ewing sarcoma. Second malignant neoplasms are relatively rare in survivors of ALL treated without radiation. Even more unusual is the development of Ewing sarcoma as the SMN. Pediatr Blood Cancer 2005; 45:57–59. © 2005 Wiley‐Liss, Inc.
Whole body hyperthermia in adjuvant therapy of children with renal cell carcinoma
Authors: Ismail‐zade Reiman S. , Zhavrid Edvard A. , Potapnev Michael P. 
Published: February 2005

AbstractWhole body hyperthermia (WBH) in combination with chemotherapy has been proven to be effective in some patients with advanced malignancies. However, only limited experience exists regarding the application of WBH with chemotherapy in children. We present the results of applying WBH and chemotherapy in five children with advanced renal cell carcinoma (RCC). WBH (3 hr, 41.8–42.5°C) combined with doxorubicin (50 mg/m2) and interferon‐α (3 MU/m2) were applied to patients after nephrectomy and lymph node dissection. Each patient received three to eight courses of treatment three times weekly. All children tolerated the combined therapy well without complications. Follow‐up of 7–68 months (median: 22 months) showed no tumor progression in patients with locoregional (n = 3) and metastatic (n = 2) disease. WBH with moderate dose doxorubicin and INF‐α might be a feasible treatment option in childhood RCC. Pediatr Blood Cancer 2005;44:679–681. © 2005 Wiley‐Liss, Inc.
Long‐term medical effects of childhood and adolescent rhabdomyosarcoma: A report from the childhood cancer survivor study
Authors: Punyko Judith A. , Mertens Ann C. , Gurney James G. , Yasui Yutaka , Donaldson Sarah S. , Rodeberg David A. , Raney R. Beverly , Stovall Marilyn , Sklar Charles A. , Robison Leslie L. , Baker K. Scott 
Published: February 2005

AbstractBackgroundThis study was conducted to evaluate the incidence of adverse medical conditions and to assess the risk of developing these conditions in a cohort of long‐term survivors of rhabdomyosarcoma (RMS) diagnosed before age 21.ProcedureUsing data from the Childhood Cancer Survivor Study (CCSS), we evaluated the incidence of self‐reported adverse medical conditions for 606 RMS survivors and 3,701 siblings of cancer survivors. Cancer and treatment data abstracted from medical records were used to evaluate the effects of primary tumor site and combined modality therapy on the risk of developing sequelae in survivors.ResultsThe relative risk (RR) for developing sequelae among survivors compared with siblings was greatest within 5 years after diagnosis. RR was elevated more than 5 years after diagnosis for several conditions (RR, 95% CI) as follows: eye impairment (cataract: 7.4, 2.9–18.9; visual disturbances: 3.2, 2.0–5.1; very dry eyes: 2.0, 1.2–3.3), endocrine impairment (growth hormone deficiency: 83.9, 33.0–213.6; hypothyroidism: 6.9, 4.1–11.3; need for medications to induce puberty: 90.4, 30.2–270.5), cardiopulmonary impairment (congestive heart failure: 43.0, 12.7–145.5; angina‐like symptoms: 2.0, 1.3–2.9), neurosensory impairment (legal blindness: 9.8, 4.8–20.0; abnormal sensations: 1.5, 1.0–2.2), and neuromotor impairment (repeated seizures: 2.3, 1.2–4.4; motor problems: 3.7, 2.2–6.4; problems chewing or swallowing: 3.8, 1.9–7.5).ConclusionsSurvivors are at risk for developing sequelae many years after their initial diagnosis and treatment. Continued medical surveillance is necessary to ensure the long‐term health and well‐being of RMS survivors. Pediatr Blood Cancer 2005;44:643–653. © 2005 Wiley‐Liss, Inc.