The Impact of 3D Foot Alignment on Detection of Distal Tibiofibular Syndesmotic Widening after Injury using Comparative Contralateral Distance Mapping
Authors: Talaski Grayson M. , Dibbern Kevin , Mallavarapu Vineel , Jasper Ryan , Schmidt Eli , Behrens Andrew , Kim Ki Chun , Carvalho Kepler A.M. , Mansur Nacime Salomao Barbachan , Anderson Donald D. , de Cesar Netto Cesar 
Published: December 2023

Category: Ankle; Trauma Introduction/ Purpose: Previous studies identified a link between increased hindfoot valgus and distal tibiofibular syndesmosis (DTFS) widening in patients with flatfoot deformity using foot-ankle offset (FAO). However, it is not known what the impact of 3D foot alignment is on the DTFS in the presence of a known syndesmotic injury, particularly in varus. Weight-bearing Computed Tomography (WBCT) has emerged as a highly precise tool for diagnosing deformities of the foot and ankle. Under weight-bearing, it is possible to precisely detect deviations in DTFS stability. The objective of this cadaveric study was to determine the relationship between hindfoot alignment, measured by FAO, and DTFS widening in specimens with complete DTFS ligamentous injury. We hypothesized that DTFS widening would be significantly greater in specimens with increased hindfoot valgus. Methods: Two WBCT scans of the foot and ankle were obtained for each of 17 matched pairs (34 legs) of through-knee cadaveric specimens in a radiolucent frame under 80lbs of load to simulate double legged stance, a baseline scan with intact syndesmotic ligaments and a second after surgical ligament sectioning. All syndesmotic ligaments were released through a direct lateral approach to the distal fibula. Models of the bones were created from scans using Disior Bonelogic. Distance mapping was used to evaluate DTFS widening over the entire DTFS interface, as well as the anterior/posterior sections, in the first 1cm, 3cm, and 5cm from the joint after injury. Post-injury distance maps were compared to the contralateral baseline normal scan as a control. FAO was measured post-injury and compared to the difference in DFTS widening between the injured leg and its contralateral, healthy control. Linear regression and Spearman’s correlations were used to evaluate relationships. Results: Significant correlations between hindfoot alignment and DTFS widening were identified at every level in the syndesmosis. The Spearman’s rho values for the entire DTFS interface at 1cm, 3cm, and 5cm were 0.393 (p = 0.0316), 0.458 (p = 0.0101), and 0.369 (p = 0.0446), respectively. Anterior Spearman’s rho values at 1cm and 3cm were 0.453 (p = 0.0119) and 0.420 (p = 0.0209), respectively. Inter-observer variability of the FAO measurements showed no statistical difference (p = 0.4248). Extremely varus FAO measurements (FAO < -10%) showed negligible changes in syndesmotic opening. Linear regression also demonstrates a positive trend. The R2 values for the entire interface at 1cm, 3cm, and 5cm were 0.127, 0.213, and 0.158. Anterior R2 values at 1cm and 1cm were 0.133 and 0.1583. Conclusion: In this cadaveric study, we confirmed our hypothesis showing that valgus FAO was correlated with syndesmosis opening from an uninjured to an injured site. These data are in accord with prior findings relating FAO and DTFS opening in flatfeet and additionally demonstrate a stronger positive trend in the presence of known injury with smaller changes in tibiofibular distances after injury for extreme varus alignments. This study provides important context to the clinically relevant comparison of contralateral feet. The trend in our data allows for predictable results for the degree of injury in patients with valgus foot alignment.