bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organic and inorganic pollutants removal from tannery effluent using electrocoagulation technique
Authors: Muthukrishnaraj Appusamy , Kalaivani Semmedu Selvaraj , Visagamani Arularasu M. , Ayyar Manikandan , Kosiha Arumugam , Dinesh Ayyar , Padmapriya Govindaswamy , Rathinavel Subramanian , Padmavathi Kandasamy , Hashem Mohamed , Fouad Hassan , Ansari AbuZar 
Published: December 2023

Abstract
Electrocoagulation is an efficient treatment for the concurrent elimination organic and inorganic contaminants from tannery wastewater. The batch electrocoagulation investigations were carried out using mild steel and aluminium as sacrificial anodes and stainless steel as the cathode. Various operating constraints, such as the electrolyte pH, realistic current density, electrolysis time, effluent concentration and supporting electrolyte concentration were appraised to study their effects on electro-coagulation efficiency. The maximum Total Organic Carbon (TOC) removal has been observed was 90 % and 77 % under optimum operating conditions, and the maximum chromium removal has been recorded was 99 % and 90 % using mild steel and aluminium anodes respectively. The experimental data was also fitted with the first order kinetic model. The experimental data were investigated with the Langmuir and Freundlich adsorption isotherm models. The result shows that the experimental data fitted with the Langmuir isotherm model, with a rate of confidence of 0.98, using mild steel as an anode. The solid sludge and the liquid samples were characterized using the SEM (scanning electron microscopy) EDX (energy dispersive X-ray spectrometry), FT-IR (Fourier transform infrared spectrometer) and UV–Visible (Ultraviolet–visible spectroscopy) analyses. All experimental results show that mild steel was an efficient anode, for the instantaneous elimination of organic and inorganic contaminants from tannery wastewater.
The Global Dynamics of Inequality (GINI) project: analysing archaeological housing data
Authors: Bogaard Amy , Ortman Scott , Birch Jennifer , Cervantes Quequezana Gabriela , Chirikure Shadreck , Crema Enrico R. , Cruz Pablo , Feinman Gary , Fochesato Mattia , Green Adam S. , Gronenborn Detlef , Hamerow Helena , Jin Guiyun , Kerig Tim , Lawrence Dan , McCoy Mark D. , Munson Jessica , Roscoe Paul , Rosenstock Eva , Thompson Amy , Petrie Cameron A. , Kohler Timothy A. 
Published: December 2023

AbstractThe GINI project investigates the dynamics of inequality among populations over the long term by synthesising global archaeological housing data. This project brings archaeologists together from around the world to assess hypotheses concerning the causes and consequences of inequality that are of relevance to contemporary societies globally.
Proliferative diabetic retinopathy as the initial presenting feature of type 1 diabetes
Authors: Ranathunga Ishara , Idampitiya Chandima 
Published: December 2023

Summary
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder caused by the destruction of the pancreatic beta cells, which produce insulin. Individuals with T1DM usually require at least 3-5 years to develop microvascular complications in comparison to people with type 2 diabetes (T2DM), who may develop complications even before the diagnosis of diabetes. We discuss a patient who presented with proliferative diabetic retinopathy subsequently diagnosed with T1DM and diabetic neuropathy following investigations. Diabetic retinopathy or other microvascular complications as the presenting feature of T1DM is rarely known or reported in the literature. A 33-year-old healthcare worker had been seen by the opticians due to 1-week history of blurred vision. The ophthalmology assessment had confirmed proliferative retinopathy in the right eye and severe non-proliferative retinopathy in the left eye with bilateral clinically significant macular oedema. His BMI was 24.9 kg/m2. The nervous system examination revealed bilateral stocking type peripheral neuropathy. The random venous glucose was 24.9 mmol/L. Plasma ketones were 0.7 mmol/L and HbA1c was 137 mmol/mol. On further evaluation, the anti-glutamic acid decarboxylase (GAD) antibody was positive, confirming the diagnosis of T1DM. He was started on aflibercept injections in both eyes, followed by panretinal photocoagulation. Subsequent nerve conduction studies confirmed the presence of symmetrical polyneuropathy. The pathogenesis of the development of microvascular complications in T1DM is multifactorial. Usually, the development of complications is seen at least a few years following the diagnosis. The occurrence of microvascular complications at presentation is rare. This makes the management challenging and extremely important in preventing the progression of the disease.

Learning points

The pathogenesis of the development of microvascular complications in type 1 diabetes mellitus is multifactorial.

The development of complications is seen at least a few years following the diagnosis.

Occurrence of microvascular complications at presentation is rare.

This makes the management challenging and extremely important to prevent the progression of the disease.
Saberes e Competências dos Higienistas de Serviços Gerais Frente à Pandemia de COVID-19: um relato de experiência sobre formação continuada de forma híbrida
Authors: Junior Mauricio Vieira Dias , Tenório Celsa Maria Calheiros de Emeri 
Published: December 2023

A pandemia da Covid-19 gerou grandes desafios na educação. Nesse contexto estabeleceu-se o objetivo deste estudo, que relata a experiência do planejamento de um curso de formação continuada, de forma híbrida, destinada à capacitação profissional dos higienistas de serviços gerais do , com foco no aprimoramento de saberes e competências, frente à pandemia. Foram utilizados os recursos metodológicos da pesquisa-ação fundamentada na perspectiva crítico-reflexiva. As etapas foram: diagnóstico situacional (etapa I), elaboração do plano de curso (etapa II), divulgação e sensibilização (etapa III) e realização do curso de capacitação continuada (etapa IV). O resultado foi considerado exitoso.
The effect of DNA methyltransferase 3A suppression in progression of the resistance phenotype in breast cancer cells
Authors: Andreeva O. E. , Sorokin D. V. , Vinokurova S. V. , Shchegolev Yu. Yu. , Elkina N. V. , Katargin A. N. , Faskhutdinov R. S. , Salnikova D. I. , Scherbakov A. M. , Krasil’nikov M. A. 
Published: December 2023

Introduction. Rearrangement of molecular pathways and activation of bypass signaling determine the progression of tumor cell resistance to various drugs. Study of the common features of resistant formation mechanisms is essential for breast and other cancer beneficial treatments.Materials and methods. The present work was performed on estrogen receptor α ERα-positive (ERα – estrogen receptor α) McF-7 breast cancer cells, established sublines resistant to the mTOR inhibitor rapamycin or antiestrogen tamoxifen, and ERα-negative MDA-MB-231 breast cancer cells. Methods used include MTT test, transient transfection, immunoblotting, real-time polymerase chain reaction and methylation analysis by bisulfite pyrosequencing.Results. We have shown that the resistance of breast cancer cells to targeted and hormonal drugs is associated with the suppression of DNA methyltransferase 3A (DNMT3A) and respective changes in DNA methylation; DNMT3A knockdown results in the partial resistance to both drugs demonstrating the pivotal role of DNMT3A suppression in the progression of cell resistance.Conclusion. Totally, the results obtained highlight the possible mechanism of tumor cell resistance to targeting/hormonal drugs based on the deregulation of DNMTs expression and demonstrate direct connection between DNMT3A suppression and resistance progression.
Relationship of transposable elements with long non-coding RNAs and peptides in carcinogenesis
Authors: Mustafin R. N. 
Published: December 2023

It has been proven that 98 % of the human genome is transcribed. The main part of resulting molecules after their processing function as various RNA molecules, among which the best known are long noncoding RNA (lncRNA) and microRNA. There are 126,000 lncRNA genes in humans that regulate transcription, translation, histone modifications, heterochromatin formation, splicing, microRNA expression and formation, and matrix RNA (mRNA) post-transcriptional modifications. An important property of lncRNAs is their mutual and self-regulation by peptides formed during their translation, which also affect the expression of protein-coding genes. This property may be due to origin of lncRNAs from transposable elements and is a conservative evolutionary characteristic of lncRNA, as one of properties in formation of new genes for variability and adaptation. The role of lncRNAs originating from retroelements and microRNAs formed during their processing in the specific regulation of genes involved in carcinogenesis has been proven. The peptides formed during lncRNA translation can be used as universal tools for targeted therapy of malignant neoplasms. Analysis of the scientific literature made it possible to describe 21 lncRNAs that are translated to form peptides involved in specific tumors pathogenesis. Since the ability of lncRNA to self-regulate by products of its own translation, which is characteristic of all lncRNAs, is also a property of transposable elements, it is promising to study transposons and their relationship with lncRNAs for designing new therapeutic models.
Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen
Authors: Babyshkina N. N. , Uzyanbaev I.  A. , Dronova T.  A. , Cherdyntseva N. V. 
Published: December 2023

Growth factors signaling cascades and their interaction with the central regulatory targets of tumor cells and estrogens are considered as the main mechanisms of hormonal resistance in breast cancer. The integration of the transforming growth factor β1 (TGF-β1) and PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling pathway may result in the activation of proliferation and, as a result, the development of an in-effective response to therapy and disease progression. The review summarizes a systematic analysis of the literature data on the role of TGF-β1 signaling in the mechanisms of tamoxifen resistance to in the aspect of interaction with the PI3K/Akt/mTOR. The interaction between the estrogen receptors α signaling and tamoxifen, the mechanisms of regulatory activation of TGF-β1 and PI3K/Akt/mTOR, as well as their contribution to the tamoxifen response are considered. The direct involvement of TGF-β1/PI3K in the mechanisms of tamoxifen resistance to determines the prospects for studying the effector of these cascades as molecular targets. The knowledge accumulated to date allows considering the TGF-β1/PI3K signaling pathway as a potential molecular tool for the search for effective strategies for blocking the resistance of tumor cells to tamoxifen.
Acceptance of Information and Communication Technology and Its Related Factors among Older Adults; a Cross-Sectional Study in Iran
Authors: Rezaeipandari Hassan , Dehghanbanadaki Elahe , Madadizadeh Farzan 
Published: December 2023

Introduction: Given the increasing elderly population and the decreasing role of families in elderly care, the use of up-to-date technologies by older adults will become increasingly important in helping them live healthier and better lives. This study aimed to determine the acceptance of information and communication technology (ICT) by older adults and related factors in Yazd city, Iran.

Methods: This cross-sectional study was conducted in 2022 with the participation of 360 older adults aged over 60 years from comprehensive health care centers in Yazd city, Iran. Participants were selected using a multi-stage random sampling method. Data were collected using a demographic information questionnaire and an Information and Communication Technology Acceptance Questionnaire completed by interview. Data were analyzed using descriptive indices, independent two-sample t-tests, one-way analysis of variance, and regression by SPSS.

Results: The ICT acceptance rate among older adults was 22.5%. The highest mean score was related to the dimension of perceived usefulness (15.37). The most significant barriers to ICT acceptance were lack of interest (48.6%), lack of sufficient skills (46.4%), and lack of perceived need (45.3%). The regression results showed that age, level of education, smartphone use, and time spent on technology tools were predictors of ICT acceptance by older adults, accounting for 82% of the variance in ICT acceptance.

Conclusion: Given the low level of technology acceptance among older adults in Yazd city and the need to learn and use ICT to meet their individual, social, health, and medical needs, as well as to live a more independent life and save time and costs, providing older adults with the opportunity to become familiar with technology is essential.
Effectiveness of English Language Teaching on Aggression and Anxiety in the Elderly with Alzheimer’s Disease
Authors: Mehrara Maryam , Rad Neda Fatehi , Jalali Valeh 
Published: December 2023

Introduction: When aging starts, the human being becomes prone and vulnerable to a variety of diseases and disorders, specifically Alzheimer’s disease (AD), which is the main reason for about 80% of the cases of dementia in older adults. AD is associated with a range of challenging disorders, such as aggression and anxiety, which make the lives of patients more difficult. This study aimed at investigating the impact of English language teaching on aggression and anxiety among older people with AD.

Methods: The design of this study was quasi-experimental pre-test post-test with the control group. The participants of the study included 40 Iranian (20 males and 20 females) older adults (≥ 65 years) who were suffering from AD in Kerman province, Iran, and also they were selected through convenience sampling. The exercise group participated in 20 sessions of English language teaching three times a week in 40 minutes. Then, the effect of English language teaching on both aggression and anxiety was analyzed. The required data were collected through the Persian version of the Bass-Perry Aggression Questionnaire and the Persian version of the Spielberger State‐Trait Anxiety Inventory. Data analysis was conducted by running descriptive statistics, Kolmogorov-Smirnov normality test, Leven test, and one-way Analysis of Covariance (ANCOVA).

Results: English language teaching significantly affected aggression among older people with AD (F= 9.112 p < 0.05, w2 = 0.178) similarly; it significantly affected anxiety (F = 9.147 p < 0.05, w2 = 0.130).

Conclusion: English language teaching significantly improves aggression and anxiety among older people with AD. The findings have implications for the elderly with AD and their families, psychiatrists, and English language teaching policymakers.
Violencia en las relaciones de noviazgo en estudiantes universitarios de enfermería
Authors: Cortaza Ramírez Leticia , Torres Lagunas María de los Ángeles , Vega Morales Elsy Guadalupe , André Matos Marcos , Hermida Flores Alejandra 
Published: December 2023

Objetivo: Identificar la percepción de violencia en las relaciones de noviazgo en estudiantes de enfermería de una Universidad Pública de Minatitlán, Veracruz México.
Materiales y Métodos: Estudio descriptivo, transversal y correlacional, la muestra fueron 182 estudiantes de enfermería inscritos en una universidad pública, de Minatitlán, Veracruz, México. El muestreo fue aleatorio simple. Se utilizó el Cuestionario de Violencia en las Relaciones de Parejas jóvenes (VIREPA), integrado por 20 ítems con una escala tipo Likert con 5 opciones de respuesta y preguntas sociodemográficas.
Resultados: El 26.9% de los estudiantes indicó maltrato en sus relaciones pasadas y 3.8% maltrato en su relación actual. Se encontraron diferencias entre hombres y mujeres, en el maltrato emocional (z=-2.248, p=0.004) y el control social y económico (z=-2.681, p=0.002) con datos más elevados en los hombres. La edad del participante y la edad de la pareja se relacionó con el maltrato emocional, físico y psicológico y la desvalorización personal (p<0.05).
Conclusiones: Los estudiantes universitarios de enfermería, han percibido experiencias de violencia durante sus relaciones de noviazgo, conducta que puede pasar desapercibida tanto para el perpetrador como para la víctima, por lo que se considera relevante el diseño de programas de prevención de la violencia en los contextos universitarios, dirigidos a identificar la violencia y su impacto en el estudiante, que aporte conocimiento y dé oportunidad para identificar cuando están viviendo una situación violenta dentro de sus relaciones de noviazgo.

Palabras clave: Violencia; Percepción; Estudiantes; Enfermería.
Estado emocional usando DASS-21 en enfermos post COVID-19 en primer nivel de atención en salud
Authors: Carrillo-Avilés Ángel Francisco , García-Torres Osvaldo , Obeso-Sandoval Indira Susana 
Published: December 2023

Objective: “Determine the emotional state following the DASS-21 in post-COVID-19 patients at the first level of health care”.
Material and methods: Observational, cross-sectional, descriptive study conducting a survey on the emotional state (DASS-21; Lovibond and Lovibond, 1995) in post-COVID-19 patients in a sample of 70 patients from the Family Medicine Unit No. 34 annex Ambulatory Care Medical Unit of La Peace, Baja California Sur. A statistical analysis was carried out with frequencies, percentages for nominal qualitative variables, with measures of central tendency and dispersion in quantitative variables, with determination of chi2. With prior authorization from the local research committee and ethics committee.
Results: 45 female patients were found (64.3%), age 39.41 ± 13.930, with a statistical significance between anxiety and presence of severe symptoms with p= 0.014 (95%CI 0.000-0.042), depression and age group p= 0.029 (95%CI % 0.000-0.068); and no significance was found with stress.
Conclusion: Anxiety mildly and extremely severely affects post-COVID-19 patients related to the presence of severe symptoms, the depression detected was moderate and is related to the age group, while the stress detected was mild and did not present an association of variables.

Keywords: Coronavirus infections; Anxiety; Psychological distress; Depression; Emotional Adjustment.
Autoestima y consumo de cannabis en adolescentes: una revisión integrativa
Authors: Medina-Quevedo Pablo , Guzmán-Ortiz Elizabeth , Álvarez-Aguirre Alicia , Martín del campo-Navarro Alicia Sarahy , García-Campos María de Lourdes 
Published: December 2023

Objective: to identify the scientific evidence related to the influence of self-esteem on adolescent cannabis use.
Materials and method: during the period of february-april 2022, an integrative review of the scientific literature published in the last ten years (2012-2022) was carried out. The six-step methodology proposed by Toronto and Remington was used in the BVS, PubMed, TRIP and Dialnet search engines, as well as in the Redalyc, Cochrane, EBSCOhost, Web of Science and CUIDEN databases. A total of 1,491 articles were found, when applying inclusion and elimination criteria, a total of ten quantitative studies were considered in the final sample.
Results: it was found that adolescents with low self-esteem are prone to influences that encourage the initiation of cannabis use. When considered as a positive attitude of the person towards himself, it favors the feeling of security and regulates behavior through a process of self-evaluation, so that it enables adolescents to adapt to their environment. In this sense, three main categories were observed: moderator variable in cannabis use; predictor variable of cannabis use; and intervention component.
Conclusions: the protective and predictive role of self-esteem for cannabis use in adolescents was demonstrated, likewise, early detection and interventions aimed at improving skills for the regulation of emotions influenced by cognitive factors are effective in the promotion and prevention of cannabis use in adolescents.

Keywords: Self-esteem; Cannabis; Adolescent; Nursing; Mexico.
INVESTIGATION OF THE RADIOLOGICAL TECHNIQUES TO DETECT OSTEOLYTIC LESIONS, FRACTURES, AND OSTEOPOROSIS IN MULTIPLE MYELOMA PATIENTS
Authors: TURGUTKAYA Atakan , YAVAŞ İrfan , ŞAHİN Tuğba , SARGIN Gokhan , KADIKÖYLÜ Gürhan , BOLAMAN Ali 
Published: December 2023

Aim: Multiple myeloma is a malignancy of clonal plasmacytes. Osteolytic lesions represent a criterion for symptomatic myeloma and are associated with bone loss, pathological fractures, and osteoporosis. Skeletal surveys with other sophisticated techniques and dual-energy x-ray absorptiometry (DEXA) are used to screen lytic lesions, and bone mineral loss, respectively. Here, we aimed to investigate the rates of detection regarding osteolytic lesions and bone mineral loss by several imaging techniques.
Materials and Methods: The study was carried out in Adnan Menderes University Hospital/Turkey, between the years 2004- 2020. Three-hundred and ten symptomatic myeloma patients were screened retrospectively. The results of radiological techniques were recorded. The detection rate of osteolytic lesions, fractures, and plasmacytomas by imaging techniques, as well as bone mineral loss with DEXA was recorded. Also, associations with gender, myeloma type, lytic lesions, and osteoporosis were investigated.
Results: Skeletal survey and PET-CT detected lytic lesions in 71.3% and 81.2% of patients, respectively. PET-CT had a sensitivity of 96.1% and specificity of 90.6% to detect lytic lesions. MRI was only used for patients with suspicious fractures and detected them for all patients who underwent MRI. The osteoporosis rate was 83.1% for 113 patients who underwent DEXA. Any association between lytic lesions and gender/myeloma type was not detected.
Conclusion: Our study demonstrated that osteolytic lesions are not correlated with gender or myeloma type. PET-CT is a sensitive and specific method for detecting osteolytic lesions. Although DEXA is sensitive, its specificity is limited to detect osteoporosis in patients with lytic lesions.
A Multi-Modality Fusion and Gated Multi-Filter U-net for Water Area Segmentation of Remote Sensing
Authors: Wang Rong fang , Zhang Chen chen , Chen Chao , Hao Hong xia , Li Wei bin , Jiao Li cheng 
Published: December 2023

Water area segmentation in remote sensing is of great importance for flood monitoring. To
overcome some challenges in this task, we construct the Water Index and Polarization Information
(WIPI) multi-modality dataset and propose a multi-Modality Fusion and Gated multi-Filter U-Net
(MFGF-UNet) convolutional neural network. The WIPI dataset enhances the water information and
reduces the data dimension. In particular, the Cloud-Free label provided in the database effectively
mitigates the issue of scarcity of labeled samples Since a single form or uniform kernel size cannot
handle the variety in size and shape of water bodies, we proposed the gated multi-filter inception
(GMF-Inception) module in our MFGF-UNet. Moreover, we utilize the attention mechanism by
introducing the Gated Channel Transform (GCT) skip connection and integrating GCT into GMF-
Inception to further improve model performance. Extensive experiments on three benchmarks,
including WIPI, Chengdu and GF2020 datasets demonstrate that our method achieves favorable
performance with lower complexity and better robustness against six competing approaches. For
example, on WIPI, Chengdu and GF2020 datasets, the proposed MFGF-UNet model achieves F1 of
0.9191, 0.7410, and 0.8421, respectively, which average F1 on three datasets is 0.0045 higher than the
U-Net model and reduces 62% average GFLOPs. New WIPI dataset, code and trained models have
been released on GitHub