bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Alpha Lipoic Acid on Pathogenesis of Experimental Nephrolithiasis and Epithelial Mesenchymal Transition
Authors: Kutlu T , Kazak F , Uyar A 
Published: October 2023

In this study, the effects of calcium oxalate (CaOx) crystal formation on the kidneys and the effect of alpha-lipoic acid (ALA) on this process were investigated in rats. The study consists of 6 groups with 10 rats in each group. Ethylene glycol (EG) and ammonium chloride (AC) (0.75% EG + 0.75% AC) were added to the drinking water of different groups for 7 or 14 days to induce nephrolithiasis. The effects of the CaOx on the kidneys and ALA (100 mg/kg/day/orally) on this process were investigated via histopathological, immunohistochemical, and biochemical methods. In the histopathological examination, EG+AC application for both 7 and 14 days caused crystal accumulation in the tubule lumens, cystically dilated tubules, and hydropic degeneration in the tubular epithelium. However, inflammatory cell infiltration was observed merely in 14 days. In the immunohistochemical examination, when EG+AC administration was applied for 14 days only, it caused expression of ED1, alpha smooth muscle actin (α-SMA), and vimentin in the tubulointerstitial areas. However, α-SMA and vimentin expression was not observed in tubular epithelial cells. Transforming growth factor beta-1 (TGF-β1) expression was also detected in the tubular epithelium and intertubular cells at 14 days. It was determined that ALA administration with EG+AC application reduced the crystal accumulation in the tubule lumens (p<0.001), the degeneration of the tubular epithelium (p<0.001), and the expression of TGF-β1. In addition, it was detected that ALA caused an increase in glutathione peroxidase (GPx) (p<0.001) and Catalase (CAT) (p>0.05) activities, which decreased with EG+AC application.
First report of detection of Canine Parvovirus type 2 in naturally infected domestic cats in Egypt by duplex PCR for simultaneous detection of Canine Parvovirus type 2 and Feline Panleukopenia virus
Authors: Magouz AF , Elkon I , Khaled E , Alkhalefa N 
Published: October 2023

Feline Panleukopenia virus (FPLV) and Canine Parvovirus type 2 (CPV) cause fatal gastroenteritis in cats and dogs. In this study we developed a duplex polymerase chain reaction (dPCR) assay for the concurrent detection of FPLV and CPV-2 in a single PCR tube. Two primers were used based on nucleic acid conserved regions of the two viruses which specifically amplify 237 bp of the VP2 gene of FPLV and 583 bp of the VP2 gene of CPV 2.Sensitivity and Specificity of the dPCR were evaluated. A total of 30 rectal/fecal swabs were collected from domestic cats in Kafrelsheikh province, Egypt and were tested for FPLV and CPV-2 viruses using the dPCR assay. The results revealed that this dPCR assay was sensitive, as it could detect a minimum of 1 × 105 copies of genomic DNA of the two viruses. The dPCR assay was highly specific as there was no amplification of nucleic acid of other feline and canine pathogens. The positive ratio was 83.3% (25/30) for FPLV and 16.6% (5/30) for CPV respectively. Further analyses of CPV samples by Restriction Fragment Length Polymorphism (RFLP) revealed that they are classified as CPV 2a/2b variants. This study reports the first detection of CPV 2a/2b from symptomatic cats in Egypt using dPCR assay that can detect FPLV and CPV in a single tube reaction.
Establishment of AA-NAT, SCD, PROP1, and IGFBP3 gene frequency distributions in Karacabey Merino and Kivircik Sheep Breeds
Authors: Dinçel D , Çobanoğlu Ö 
Published: October 2023

Thus, the aim of the current study was to investigate the genotypic dispersion of AA-NAT, SCD, PROP1, and IGFBP3 genes in the target population. Primarily, the genomic DNA was isolated from blood samples by the phenol/chloroform method. The genomic analyses were performed on a total of 160 Karacabey Merino (KM) sheep (n=80) and Kivircik (n=80). The PCR-RFLP method was used to determine the genotype of the SNPs. Deviation from Hardy–Weinberg equilibrium (HWE) and population genetic assays such as observed (Ho) and expected (He) heterozygosities, effective allele numbers (Ne), and the polymorphism information content (PIC) were calculated for each gene in the population. As a result, there was no deviation from HWE was determined except SCD and PROP1 gene in KM. The most frequent genotypes were found AA (66,25% and 87,50%) for AA-NAT gene, CC (93,75% and 91,25%) for SCD gene and CC genotype (70,00% and 56,25%) for PROP1 gene in KM and Kivircik sheep. All breeds were detected monomorphic in terms of the IGFBP3 gene. In conclusion, the other regions of the IGFBP3 gene which were determined as monomorphic in the studied flock could be researched. Moreover, further studies should be necessary for defining the effects of investigated genes on related traits in KM and Kivircik sheep in terms of polymorphic genes specified.
Occurrence and molecular characterization of Salmonella Typhimurium and Salmonella Enteritidis isolates from contaminated food samples from Palestine
Authors: Adwan G , Abuseir S , Khreishi O , Hussein A , Khraim N , Abed Al-Daym M 
Published: October 2023

Salmonella is one of the most frequently isolated foodborne pathogens. It is of major public health concern worldwide. Poultry meat and eggs represent an important source of Salmonellae organism for consumer health. This study aimed to evaluate the occurrence of Salmonella enterica serotype Typhimurium and Enteritidis using multiplex PCR (mPCR) among isolates collected from the local market and to assess genetic relationships between isolates of S. Typhimurium, which was the only serotype isolated from the tested food samples. This was done using virulence factors profiling and fingerprint profiling by random amplified polymorphic DNA (RAPD-PCR) and repetitive sequence PCR (REP-PCR) using enterobacterial repetitive intergenic consensus (ERIC-PCR) and interspersed repetitive DNA sequence BOXAIR-PCR.
The overall occurrence percentage of S. Typhimurium and S. Enteritidis out of 51 isolates was 54.9% and 0.0%, respectively. Only 13 out of 17 virulence genes were detected in these isolates. The occurrence of the detected virulence genes among these isolates was 100%, 50.0%,46.4%, 39.3%, 35.7%, 35.7%, 32.1%, 25.0%, 25.0%, 17.6%, 14.3%, 14.3%, 3.6% for invA, sopB, prgH, sitC, pefA, tolC, cdtB, msgA, sifA, iroN, spiA, ipfC and pagC, respectively. The remaining virulence genes were absent in all of the isolates. Based on the combination of the presence and absence of virulence genes, eight profiles were detected among these isolates, the most common genetic profile was V5 (each 32.1%). Based on this genetic profile at cut-off point 96.0%, both ERIC and BOX primers allowed for discrimination into 4 and 6 clusters or clones of 16 S. Typhimurium isolates, respectively. Results of PCR typing methods showed that, three strains clustered together using both ERIC-PCR and BOX-PCR typing methods and they had the same virulotype (V1), while other four strains also clustered together by both typing methods and had the same virulotype (V8).
Contamination of food with Salmonellae especially with S. Typhimurium was high and indicated a bad microbiological quality of food. This emphasizes the need for rigorous public health and food safety methods to lower the human health hazard and risk associated with Salmonellae infection.
Patent Foramen Ovale–Related Hypoxemia After Bilateral Lung Transplant
Authors: Raavi Lekhya , Garg Pankaj , Alomari Mohammad , Ali Mostafa , Wadiwala Ishaq , El-Sayed Ahmed Magdy M. 
Published: October 2023

Abstract
A 64-year-old man with interstitial pulmonary fibrosis and a small patent foramen ovale with right-to-left shunting underwent bilateral lung transplant without closure of the patent foramen ovale. Postoperatively, the patient remained persistently hypoxemic with partial response to high-flow oxygen. Investigations revealed the presence of a large patent foramen ovale with right-to-left shunting on echocardiography and a shunt fraction of 21% on cardiac catheterization. Two months after the lung transplantation, primary surgical repair of the patent foramen ovale was performed with immediate improvement in oxygenation. Three years postoperatively, the patient remained oxygen independent.
Perlakuan Air Panas dan Plant Growth Promoting Rhizobacteria untuk Menekan Cendawan Terbawa Benih pada Padi Varietas IPB-3S
Authors: Tondok Efi Toding , Andini Desi 
Published: October 2023

Hot Water Treatment and Plant Growth Promoting Rhizobacteria to Suppress Seed-Borne Fungi on Rice Variety IPB-3S
IPB-3S is a new rice variety which was developed to improve national rice production in Indonesia. This study aimed to determine seed-borne fungi associated with IPB-3S variety and to determine the potential of hot water and PGPR treatment to suppress the fungal infection. The study consisted of five experiments, i.e. seed health test by dry seed observation and by blotter test, pathogenicity test, seed treatment using hot water and plant growth promoting rhizobacteria (PGPR). Seven genera of fungi were found in IPB-3S seeds, namely Aspergillus, Penicillium, Rhizopus, Rhizoctonia, Curvularia, Fusarium and Colletotrichum. All of these fungi are pathogenic based on pathogenicity test. Seed treatment using hot water at 54 ℃ and PGPR reduced fungal infections and increased germination of IPB-3S seeds.
Financial Depth and Stock Returns in Sub-Saharan Africa: A Three-Country Comparative Study
Authors: Dare Funso David , Agbaje Wale Henry 
Published: October 2023

This study examined the relationship between financial depth indicators and the stock returns in three selected Sub-Saharan African (SSA) countries from 1990-2019 comparatively. Specifically, the study investigated the effect of financial depth variables (ratios of market capitalization to the Gross Domestic Product (GDP); monetary/liquidity in circulation (M3) to the GDP; lending/savings rate spread, financial sector contribution to GDP; credit to private sector to GDP; Central Bank assets to GDP and commercial banks liabilities to GDP) on the stock market returns of the selected Anglophone SSA countries (Kenya, Nigeria and South Africa). The study employed descriptive statistics, correlations, Johansen co-integration, vector autoregressive (VAR) and Granger causality to analyze the data of selected countries and compare the results to identify the different natures of effects of financial depth on stock returns. Results revealed, that, to a large extent, financial depth variables promote stock market growth in Kenya but there was no evidence that the former significantly affected the latter in Nigeria. However, in South Africa, financial depth variables have significant negative effect on stock returns, at least, in the short-run. These results imply that, comparatively, there are marked differences among the three countries with respect to the effect of financial depth on stock returns. Nevertheless, there is evidence of causal relationship between the variables in the three countries. The study concluded that financial depth has significant effects on stock returns in Kenya and South Africa but not in Nigeria. It is therefore recommended that monetary authorities should develop strategies that will minimize monetary policy lags which delay the transmission of policy effects on the target in the short run. Also, governments and the Central Banks of the countries under study, especially Nigeria and South Africa should re-appraise their financial depth efforts vis-à-vis stock market development.
Lung nodule segmentation via semi-residual multi-resolution neural networks
Authors: Wang Chenyang , Dai Wei 
Published: October 2023

Abstract
The integration of deep neural networks and cloud computing has become increasingly prevalent within the domain of medical image processing, facilitated by the recent strides in neural network theory and the advent of the internet of things (IoTs). This juncture has led to the emergence of numerous image segmentation networks and innovative solutions that facilitate medical practitioners in diagnosing lung cancer. Within the contours of this study, we present an end-to-end neural network model, christened as the “semi-residual Multi-resolution Convolutional Neural Network” (semi-residual MCNN), devised to engender precise lung nodule segmentation maps within the milieu of cloud computing. Central to the architecture are three pivotal features, each coalescing to effectuate a notable enhancement in predictive accuracy: the incorporation of semi-residual building blocks, the deployment of group normalization techniques, and the orchestration of multi-resolution output heads. This innovative model is systematically subjected to rigorous training and testing regimes, using the LIDC-IDRI dataset – a widely embraced and accessible repository – comprising a diverse ensemble of 1,018 distinct lung CT images tailored to the realm of lung nodule segmentation.
Case report: Herbal treatment of neutropenic enterocolitis after chemotherapy for breast cancer
Authors: Xu Peng , Cui Chaoxiong , Liu Yukun , Fang Kun , Wang Qitang , Liu Chao , Tan Ruixia 
Published: October 2023

Abstract
In this case report, a 53-year-old woman was diagnosed with severe NE after receiving chemotherapy for breast cancer. The patient with breast cancer was treated with a single cycle of docetaxel (140 mg) + epirubicin (130 mg) + cyclophosphamide (0.9 g) chemotherapy. However, the woman presented with symptoms of fatigue and diarrhea 5 days later accompanied with severe neutropenia according to the routine blood test. The computed tomography examination displayed the thickening and swelling of the colorectal wall. After the diagnosis of NE, the woman received antibiotics and supportive treatment, but her symptoms were not improved. The Chinese herbal medicine (CHM) diagnostic pattern was then designed for the patient. The patient was administered with two CHM decoctions. One decoction contained 24 kinds of herbal materials, and the other one was called pure ginseng decoction. These two decoctions were administered to the patient 2 or 3 times per day to tonify the spleen, nourish Qi and blood, and remove phlegm and damp heat symptoms. After the CHM treatment lasting for 10 days, the symptoms of the patient were improved, and she was discharged. In conclusion, CHM treatment played an indispensable role in curing the woman with chemotherapy-induced NE.
SPOP regulates the expression profiles and alternative splicing events in human hepatocytes
Authors: Dai Jing , Dong Xiang , Chen Yuxin , Xue Wanying , Wang Qingqing , Shang Feifei , Zhao Yunxia , Li Shujing , Gao Yu , Wang Yuanyuan 
Published: October 2023

Abstract
Speckle type BTB/POZ protein (SPOP) may have cancer promoting or inhibiting effects. At present, the role of SPOP in hepatocellular carcinoma (HCC) has rarely been studied. In this study, to investigate the effects of SPOP in HCC and elucidate the underlying molecular mechanisms of its relationship with genes, differentially expressed genes (DEGs) were classified through RNA sequencing. The gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes functional pathway analysis were used to further predict the function of DEGs after the overexpression of SPOP. The biological function of SPOP-regulated alternative splicing events in cells is comprehensively assessed. The Cancer Genome Atlas database and Gene Expression Omnibus dataset were performed to evaluate the correlation between SPOP and HCC progression. Due to SPOP overexpression, 56 DEGs in the HCC related pathway were further identified. The results showed that SPOP overexpression facilitated the cell proliferation and changed the gene expression profiles of human normal hepatocytes. SPOP-regulated alternative splicing events were involved in pathways associated with cellular processes, metabolism, environmental information procession, organismal systems, and so on. In conclusion, SPOP may potentially exhibit tumor-promoting effects, necessitating further investigations to unveil its molecular mechanisms comprehensively.
Investigating traffic characteristics for merging sections in Iraq
Authors: Luaibi Wafaa Khudhair , Leong Lee Vien , Al-jameel Hamid Athab 
Published: October 2023

Abstract
Recurring congestion on highways is the primary cause of traffic congestion in the urban traffic system while jams on merging sections are the worst section along the expressway. Due to the presence of heavy congestion in the site of University of Technology, this study aims to discover the traffic characteristics of this site to determine the appropriate solutions. Therefore, this study selects a merging section on Mohammed Al-Qassim expressway to investigate some characteristics of such a section in Iraq. Field data have been collected from this site for 4 h. The data were collected from video cameras installed along the expressway in Baghdad city which is called Mohammed Al-Qassim Expressway. These data present flow of upstream and ramp. The Advanced Interactive Microscopic Simulator for Urban and Non-Urban Networks (AIMSUN) program was also adopted to investigate other characteristics which are difficult to get such as speed and occupancy for the current case. The results showed that the simulated and real data significantly corresponded. In this study, the AIMSUN program received recognition by utilizing Geoffrey E. Havers a method for comparing two sets of traffic volumes that are used in traffic engineering, traffic forecasting, and traffic modeling as it was discovered to be comparable to reality, and the road management was then enhanced by the addition of ramp metering and cycle (green) time control.
Theoretical and numerical analysis of nonlinear Boussinesq equation under fractal fractional derivative
Authors: Algahtani Obaid J. 
Published: October 2023

Abstract
A nonlinear Boussinesq equation under fractal fractional Caputo’s derivative is studied. The general series solution is calculated using the double Laplace transform with decomposition. The convergence and stability analyses of the model are investigated under Caputo’s fractal fractional derivative. For the numerical illustrations of the obtained solution, specific examples along with suitable initial conditions are considered. The single solitary wave solutions under fractal fractional derivative are attained by considering small values of time

(

t

)

\left(t)

. The wave propagation has a symmetrical form. The solitary wave’s amplitude diminishes over time, and its extended tail expands over a long distance. It is observed that the fractal fractional derivatives are an extremely constructive tool for studying nonlinear systems. An error analysis is also carried out for compactness.
„Muslimische Seelsorge in öffentlichen Institutionen“ – Certificate of Advanced Studies (CAS)
Authors: Lang Andrea 
Published: October 2023

Zusammenfassung
Das Schweizerische Zentrum für Islam und Gesellschaft (SZIG) der Universität Freiburg i. Ü. hat das Certificate of Advanced Studies (CAS) „Muslimische Seelsorge in öffentlichen Institutionen“ aufgebaut, das auf Deutsch und Französisch angeboten wird. Der Artikel bietet einen Überblick zu Konzept, Aufbau und Inhalten des Weiterbildungsstudiengangs sowie zur Zusammensetzung der Teilnehmenden. Darüber hinaus werden Perspektiven für die weitere Entwicklung des Lehrangebots aufgezeigt.
Two case reports of mesenteric and retroperitoneal actinomycosis and a narrative review of the relevant literature
Authors: Ioannidis Orestis , Symeonidis Savvas , Ouzounidis Nikolaos , Foutsitzis Vasilis , Anestiadou Elissavet , Christidis Panagiotis , Loutzidou Lydia , Fesatidou Vasiliki , Kerasidou Ourania , Tsalis Konstantinos , Aggelopoulos Stamatios 
Published: October 2023

Introduction. Actinomycosis is an uncommon subacute or chronic suppurative bacterial granulomatous infectious disease with clinical heterogeneity. The majority of actinomycosis cases were of extra-abdominal origin, with oro-cervico-facial cases representing 55%, abdominopelvic representing 20%, and thoracic representing 15% of total reports. Currently, abdominal actinomycosis incidence is approximately 1 case per 119,000 people, being found three times more frequently among males. We report two rare clinical presentations of abdominal actinomycosis affecting the mesentery and the retroperitoneum, respectively.
Case Report 1. A 58-year-old Caucasian male presented to our clinic with abdominal pain in the right upper quadrant. Pre-operative evaluation, although inconclusive, showed a mesocolic mass infiltrating the right and transverse colon. The patient underwent exploratory laparotomy. After partial resection of the mass, the histopathology report demonstrated mesenteric actinomycosis.
Case Report 2. A 40-year-old Caucasian male presented to our clinic complaining about a mucopurulent material from an orifice at the right inguinal region. After appropriate work-up, a large abdominopelvic, stellate mass (75 x 22.8 mm) in the retroperitoneum was revealed. Surgery along with the appropriate antibiotics was used to treat the patient.
Conclusion. Preoperative suspicion and diagnosis of actinomycosis are very challenging, with a high rate of misdiagnosis often resulting in delayed treatment. Our case reports highlight that abdominal actinomycosis should always be part of differential diagnosis, especially when there is involvement of multiple organs. The gold standard treatment of actinomycosis is surgical excision with prolonged antibiotic treatment.
РОЛЬ НАСТАВНИКА В НАУЧНОЙ ДЕЯТЕЛЬНОСТИ МОЛОДОГО УЧЕНОГО
Authors: Сотникова Наталья Николаевна , Свечинская Татьяна Алексеевна , Костюков Константин Иванович 
Published: October 2023

Целью исследования является обоснование значимости роли наставничества, выявление затруднений в процессе формирования профессионально значимых компетенций, определение путей выхода из проблемной ситуации.
Методологическую базу исследования представляют основные принципы и методы работы наставника, выявление причинно-следственных связей и закономерностей на основе анализа статистических данных.
Результаты исследования. Данная статья рассматривает важность наставничества в научной деятельности молодых ученых, а также проблемы, с которыми сталкиваются наставники при работе с молодыми учеными. В статье представлены различные методы и подходы к наставничеству, которые могут помочь преодолеть трудности и оптимизировать процесс работы с молодыми учеными. Особый акцент сделан на значимости использования современных технологий в наставничестве, таких как дистанционное обучение и онлайн-платформы для обмена знаниями. Также в статье представлены перспективы дальнейшего развития наставничества в научной деятельности молодых ученых, включая расширение международного научного сотрудничества и улучшение качества научных исследований. Статья содержит множество практических советов и рекомендаций, которые помогут повысить эффективность работы с молодыми учеными и привести к более успешным научным исследованиям и карьерному становлению.
Перспективы исследования заключаются в создании новых подходов к работе наставника с целью дальнейшего плодотворного развития научной сферы за счет привлечения новых высококвалифицированных научных кадров.