bluuebunny/crossref_metadata_2025_split huggingface dataset:
Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89
Authors: Lin Daniel , Lechermann Laura M. , Huestis Malcolm P. , Marik Jan , Sap Jeroen B. I. 
Published: December 2023

AbstractThis review discusses recent advances in light‐driven radiochemistry for three key isotopes: fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission tomography (PET). In the case of fluorine‐18, the predominant approach involves the use of cyclotron‐produced [18F]fluoride or reagents derived thereof. Light serves to activate either the substrate or the fluorine‐18 labeled reagent. Advancements in carbon‐11 photo‐mediated radiochemistry have been leveraged for the radiolabeling of small molecules, achieving various transformations, including 11C‐methylation, 11C‐carboxylation, 11C‐carbonylation, and 11C‐cyanation. Contrastingly, zirconium‐89 photo‐mediated radiochemistry differs from fluorine‐18 and carbon‐11 approaches. In these cases, light facilitates a postlabeling click reaction, which has proven valuable for the labeling of large biomolecules such as monoclonal antibodies (mAbs). New technological developments, such as the incorporation of photoreactors in commercial radiosynthesizers, illustrate the commitment the field is making in embracing photochemistry. Taken together, these advances in photo‐mediated radiochemistry enable radiochemists to apply new retrosynthetic strategies in accessing novel PET radiotracers.
Tandem Synergistic Effect of Cu‐In Dual Sites Confined on the Edge of Monolayer CuInP2S6 toward Selective Photoreduction of CO2 into Multi‐Carbon Solar Fuels
Authors: Gao Wa , Shi Li , Hou Wentao , Ding Cheng , Liu Qi , Long Ran , Chi Haoqiang , Zhang Yongcai , Xu Xiaoyong , Ma Xueying , Tang Zheng , Yang Yong , Wang Xiaoyong , Shen Qing , Xiong Yujie , Wang Jinlan , Zou Zhigang , Zhou Yong 
Published: December 2023

AbstractOne‐unit‐cell, single‐crystal, hexagonal CuInP2S6 atomically thin sheets of≈0.81 nm in thickness was successfully synthesized for photocatalytic reduction of CO2. Exciting ethene (C2H4) as the main product was dominantly generated with the yield‐based selectivity reaching ≈56.4 %, and the electron‐based selectivity as high as ≈74.6 %. The tandem synergistic effect of charge‐enriched Cu−In dual sites confined on the lateral edge of the CuInP2S6 monolayer (ML) is mainly responsible for efficient conversion and high selectivity of the C2H4 product as the basal surface site of the ML, exposing S atoms, can not derive the CO2 photoreduction due to the high energy barrier for the proton‐coupled electron transfer of CO2 into *COOH. The marginal In site of the ML preeminently targets CO2 conversion to *CO under light illumination, and the *CO then migrates to the neighbor Cu sites for the subsequent C−C coupling reaction into C2H4 with thermodynamic and kinetic feasibility. Moreover, ultrathin structure of the ML also allows to shorten the transfer distance of charge carriers from the interior onto the surface, thus inhibiting electron‐hole recombination and enabling more electrons to survive and accumulate on the exposed active sites for CO2 reduction.
Wingtip‐Flexible N‐Heterocyclic Carbenes: Unsymmetrical Connection between IMes and IPr
Authors: Zhao Qun , Rahman Mahbubur , Zhou Tongliang , Yang Shiyi , Lalancette Roger , Szostak Roman , Szostak Michal 
Published: December 2023

AbstractIMes (IMes=1,3‐bis(2,4,6‐trimethylphenyl)imidazol‐2‐ylidene) and IPr (IPr=1,3‐ bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene) represent by far the most frequently used N‐heterocyclic carbene ligands in homogeneous catalysis, however, despite numerous advantages, these ligands are limited by the lack of steric flexibility of catalytic pockets. We report a new class of unique unsymmetrical N‐heterocyclic carbene ligands that are characterized by freely‐rotatable N‐aromatic wingtips in the imidazol‐2‐ylidene architecture. The combination of rotatable N−CH2Ar bond with conformationally‐fixed N−Ar linkage results in a highly modular ligand topology, entering the range of geometries inaccessible to IMes and IPr. These ligands are highly reactive in Cu(I)‐catalyzed β‐hydroboration, an archetypal borylcupration process that has had a transformative impact on the synthesis of boron‐containing compounds. The most reactive Cu(I)‐NHC in this class has been commercialized in collaboration with MilliporeSigma to enable broad access of the synthetic chemistry community. The ligands gradually cover %Vbur geometries ranging from 37.3 % to 52.7 %, with the latter representing the largest %Vbur described for an IPr analogue, while retaining full flexibility of N‐wingtip. Considering the modular access to novel geometrical space in N‐heterocyclic carbene catalysis, we anticipate that this concept will enable new opportunities in organic synthesis, drug discovery and stabilization of reactive metal centers.
HNBR and NBR gasket rubbers for plate heat exchangers: Thermo‐oxidative aging and service lifetime prediction
Authors: de Ruijter Pedro Quirinus , de Bittencourt Ribeiro Eduardo , Zanzi Mateus de Sousa , de Souza Elias Luiz , Goes Oliveira Jorge Luiz , Paiva Kleber Vieira , Benedet Dutra Gabriel 
Published: December 2023

AbstractAmong several available rubbers used in gaskets for plate heat exchangers, the selection of the appropriate material for each operation window is crucial. This work evaluated nitrile butadiene rubber (NBR) and hydrogenated butadiene rubber (HNBR) gaskets aged at high temperatures for up to 60 days. The properties assessed of compression set (CS), hardness, and cross‐link density demonstrated superior degradation rates for the NBR specimens. Fourier transform infrared analysis showed that the hydrogenation process predominantly affected CC double bonds. Compress stress relaxation highlighted the impact of aging on the counterforce of rubber over time. Furthermore, indentation modulus profile analysis showed heterogeneous degradation for both materials at 140°C for NBR and 170°C for HNBR. The end‐of‐life criteria of 79% CS for both materials were determined through sealing tests of the aged samples. The service lifetime prediction, using the time–temperature superposition and Arrhenius methods through the CS evolution curves, demonstrated a higher degradation resistance of HNBR gaskets, that have a superior service lifetime of at least 3.5 times at 80°C concerning those of NBR, proving a superior behavior for the hydrogenated elastomer. In addition, the evaluation of the lifetime prediction enables the verification of which rubber gasket is recommended for each operational condition in terms of material cost, service lifetime, and maintenance costs.
Process parameter optimization for ionic liquids as gas separation membranes based on a GWO–BPNN model
Authors: Mian Zhu , Bin Wang , Chao Lv , Zhenhui Yu , Liu Jingxian 
Published: December 2023

AbstractGas separation membranes offer a cost‐effective solution for capturing greenhouse gases, mitigating the global greenhouse effect. Ionic liquids (ILs) have emerged as one of the promising materials for greenhouse gas separation due to their strong affinity for CO2. In this study, we propose a laboratory‐scale method for preparing IL–PVDF blend membranes with high CO2/N2 selectivity. The separation performance of the membranes was evaluated using a custom gas permeation measurement system. The effects of casting solution composition, solidification method, and film‐forming processes on separation performance were experimental investigated, and the obtained experimental data were used to train a back propagation neural network (BPNN) optimized by the Gray Wolf Optimizer (GWO) algorithm. This hybrid GWO–BPNN model was utilized to predict separation membrane efficiency, optimize the film‐forming process, and identify the optimal range of process parameters. Notably, the GWO–BPNN model demonstrated a 2.76% higher prediction accuracy compared to a standalone BPNN. The results indicated that the GWO–BPNN algorithm has a great potential to accurately predict membrane separation efficiency and apply in optimal membrane process design (OMPD), and this method can significantly reduce the number of experimental trials required to achieve OMPD.
Two‐Dimensional Conjugated Polymers: a New Choice For Organic Thin‐Film Transistors
Authors: Zhao Wenkai , Fu Guang‐en , Yang Haoyong , Zhang Tao 
Published: December 2023

AbstractOrganic thin‐film transistors (OTFTs) as a vital component among transistors have shown great potential in smart sensing, flexible displays, and bionics due to their flexibility, biocompatibility and customizable chemical structures. Even though linear conjugated polymer semiconductors are common for constructing channel materials of OTFTs, advanced materials with high charge carrier mobility, tunable band structure, robust stability, and clear structure‐property relationship are indispensable for propelling the evolution of OTFTs. Two‐dimensional conjugated polymers (2DCPs), featured with conjugated lattice, tailorable skeletons, and functional porous structures, match aforementioned criteria closely. In this review, we firstly introduce the synthesis of 2DCP thin films, focusing on their characteristics compatible with the channels of OTFTs. Subsequently, the physics and operating mechanisms of OTFTs and the applications of 2DCPs in OTFTs are summarized in detail. Finally, the outlook and perspective in the field of OTFTs using 2DCPs are provided as well.
Correction to deep reinforcement learning‐based ordering mechanism for performance optimization in multi‐echelon supply chains
Authors: Kurian Dony S. , Pillai V. Madhusudanan 
Published: December 2023

AbstractThis paper addresses and acknowledges the valuable feedback provided by Dr. Deniz Preil in response to the recent study conducted by Kurian et al which investigates the application of proximal policy optimization (PPO) to determine dynamic ordering policies within multi‐echelon supply chains. The first comment raised by Dr. Preil motivated an examination of the training and evaluation procedures in Experiments 2, 3, and 4. The Experiments 2 and 3 were reworked to address this, allowing the seed to vary for every training iteration, resulting in refined outcomes while there was no need of reworking of Experiment 4. The second comment focused on the benchmarking strategies involving the 1‐1 policy and the order‐up‐to (OUT) policy, clarifying the distinctions between the two policies and justifying the use of the 1‐1 policy for benchmarking in Experiment 4. The implementation of the widely accepted OUT policy was explained, highlighting the meaningful rationale behind its use. These discussions aim to enhance the methodology employed by Kurian et al and strengthen the implications of the findings within the domain of supply chain ordering management.
PETR: A novel peristaltic mixed tubular bioreactor simulating human colonic conditions
Authors: Vorländer David , Schultz Gábor , Hoffmann Kristin , Rasch Detlev , Dohnt Katrin 
Published: December 2023

AbstractA novel bioreactor simulating human colonic conditions for in vitro cultivation of intestinal microbiota is presented. The PEristaltic mixed Tubular bioReactor (PETR) is modular designed and periodically kneaded to simulate intestinal peristalsis. The reactor is introduced, characterized from a bioprocess engineer's perspective and discussed in its ability to mimic colon conditions. PETR provides physiological temperature and appropriate anaerobic conditions, simulates intestinal peristalsis, and has a mean residence time of 32.8 ± 0.8 h comparable to the adult human colon. The single‐tube design enables a time‐constant and longitudinally progressive pH gradient from 5.5 to 7.0. Using a dialysis liquid containing high molecular weight polyethylene glycol, the integrated dialysis system efficiently absorbs short chain fatty acids (up to 60%) and water (on average 850 mL d−1). Cultivation of a typical gut bacterium (Bifidobacterium animalis) was performed to demonstrate the applicability for controlled microbiota cultivation. PETR is unique in combining simulation of the entire colon, peristaltic mixing, dialytic water and metabolite absorption, and a progressive pH gradient in a single‐tube design. PETR is a further step to precise replication of colonic conditions in vitro for reliable and reproducible microbiota research, such as studying the effect of food compounds, prebiotics or probiotics, or the development and treatment of infections with enteric pathogens, but also for further medical applications such as drug delivery studies or to study the effect of drugs on and their degradation by the microbiota.
Telehealth of cardiac devices for CVD treatment
Authors: Shelke Sushil , Veerubhotla Krishna , Lee Yugyung , Lee Chi H. 
Published: December 2023

AbstractThis review covers currently available cardiac implantable electronic devices (CIEDs) as well as updated progress in real‐time monitoring techniques for CIEDs. A variety of implantable and wearable devices that can diagnose and monitor patients with cardiovascular diseases are summarized, and various working mechanisms and principles of monitoring techniques for Telehealth and mHealth are discussed. In addition, future research directions are presented based on the rapidly evolving research landscape including Artificial Intelligence (AI).
Beyond metal–air battery, emerging aqueous metal–hydrogen peroxide batteries with improved performance
Authors: Liu Jiehua , Zhou Meng , Jin Ke , Li Jun , Meng Fancheng , Wei Xiangfeng 
Published: December 2023

AbstractThe aqueous metal–H2O2batteries have been paid rapidly increasing attention due to their large theoretical energy densities, attractive power density, and multiple applications (air, land, and sea), especially in low‐content oxygen or nonoxygen conditions in which metal–air cells are out of work. However, the requirements of metal–H2O2batteries are different due to the order of metal activities (Mg > Al > Zn) as well as metal–air cells. Aqueous metal–H2O2batteries mainly include Al–H2O2, Mg–H2O2, and Zn–H2O2batteries with the respective scientific problems, including battery structures, single/dual‐electrolyte systems, electrocatalysts for O2reduction/evolution reactions, H2O2reduction/production/decomposition, and the designability of anode to inhibit self‐corrosion. In this review, we summarized battery architectures, possible mechanisms, and recent progress in metal–H2O2batteries, including Al–H2O2, Mg–H2O2, and Zn–H2O2batteries. Several perspectives are also provided for these research fields, which may be focused on in the future.
Patient perspectives on factors influencing active surveillance adherence for low‐risk prostate cancer: A qualitative study
Authors: Subramanian Lalita , Hawley Sarah T. , Skolarus Ted A. , Rankin Aaron , Fetters Michael D. , Witzke Karla , Chen Jason , Radhakrishnan Archana 
Published: December 2023

AbstractBackgroundProstate cancer is the most common cancer among men in the United States. Treatment guidelines recommend active surveillance for low‐risk prostate cancer, which involves monitoring for progression, to avoid or delay definitive treatments and their side effects. Despite increased uptake, adherence to surveillance remains a challenge.MethodsWe conducted semi‐structured, qualitative, virtual interviews based on the Theoretical Domains Framework (TDF), with men (15) who were or had been on active surveillance for their low‐risk prostate cancer in 2020. Interviews were transcribed and coded under TDF's behavioral theory‐based domains. We analyzed domains related to adherence to surveillance using constructivist grounded theory to identify themes influencing decision processes in adherence.ResultsThe TDF domains of emotion, beliefs about consequences, environmental context and resources, and social influences were most relevant to surveillance adherence‐. From these four TDF domains, three themes emerged as underlying decision processes: trust in surveillance as treatment, quality of life, and experiences of self and others. Positive perceptions of these three themes supported adherence while negative perceptions contributed to non‐adherence (i.e., not receiving follow‐up or stopping surveillance). The relationship between the TDF domains and themes provided a theoretical process describing factors impacting active surveillance adherence for men with low‐risk prostate cancer.ConclusionsMen identified key factors impacting active surveillance adherence that provide opportunities for clinical implementation and practice improvement. Future efforts should focus on multi‐level interventions that foster trust in surveillance as treatment, emphasize quality of life benefits and enhance patients' interpersonal experiences while on surveillance to optimize adherence.
MDSC suppresses T cell antitumor immunity in CAC via GPNMB in a MyD88‐dependent manner
Authors: Wang Bo , Wang Lu , Shang Runshi , Xie Lin 
Published: December 2023

AbstractBackgroundMyeloid‐derived suppressor cells (MDSCs) played an essential role in tumor microenvironment to suppress host antitumor immunity and help cancer cells escape immune surveillance. However, the molecular mechanism behind tumor evasion mediated by MDSCs is not fully understood. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is considered to associate with tumor initiation, metastasis and angiogenesis. Blocking GPNMB function is a potentially valuable therapy for cancer by eliminating GPNMB+MDSCs. Our previous study has proved that blockage the MyD88 signaling with the MyD88 inhibitor, TJ‐M2010‐5, may completely prevent the development of CAC in mice, accompanying with downregulation of GPNMB mRNA in the inhibitor‐treated mice of CAC.MethodsWe here focus on the underlying the relationship between GPNMB function and MyD88 signaling pathway activation in MDSCs' antitumor activity in CAC.ResultsCAC development in the mouse model is associated with expanded GPNMB+MDSCs by a MyD88‐dependent pathway. The GPNMB expression on MDSCs is associated with MyD88 signaling activation. The inhibitory effect of MDSCs on T cell proliferation, activation and antitumor cytotoxicity in CAC is mediated by GPNMB in a MyD8‐dependent manner.ConclusionMyD88 signaling pathway plays an essential role in GPNMB+MDSC‐mediated tumor immune escape during CAC development and is a promising focus for revealing the mechanisms of MDSC that facilitate immunosuppression and tumor progression.
Antifungal and Antiproliferative Activity of Pistagremic Acid and Flavonoids Extracted from the Galls ofPistacia chinensissubsp.integerrima
Authors: Rauf Abdur , Anyanwu Margrate , Aliiri Ahmad A. , Alanazi Hamdan A. H. , Alharbi Abdulrahman M. A. , Wadood Abdul , Aljohani Abdullah S. M. , Muhammad Naveed , Samad Abdus , Shah Syed Uzair Ali , Gianoncelli Alessandra , Ribaudo Giovanni 
Published: December 2023

AbstractPistacia chinensissubsp.integerrima(J.L. Stewart) Rech. f. is a plant known for its therapeutic applications in traditional medicine, which are related to its antimicrobial, anticancer, antioxidant, anti‐inflammatory, analgesic, antidiarrheal, and muscle relaxant properties. The galls ofP. chinensisare rich in triterpenes and flavonoids, and we here report the extraction of pistagremic acid (1), apigenin (2) and sakuranetin (3) from this source. The isolated compounds were tested againstAspergillus flavus,Candida albicans,Candida glabrata,Fusarium solani, Microsporum canisandTrichoderma longibrachiatum. The results highlighted the antimicrobial activity of flavonoids2and3, suggesting that this class of molecules may be responsible for the effect related to the traditional use. On the other hand, when the compounds and the extract were tested for their antiproliferative activity on a panel of 4 human cancer cell lines, the triterpene pistagremic acid (1) showed a higher potential, thus demonstrating a different bioactivity profile. Structure‐based docking and molecular dynamics simulations were used to help the interpretation of experimental results. Taken together, the here reported findings pave the way for the rationalization of the use ofP. chinensisextracts, highlighting the contributions of the different components of galls to the observed bioactivity.
Concomitant percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation
Authors: Fischer Julius , Steffen Julius , Arlart Tobias , Haum Magda , Gschwendtner Sarah , Doldi Philipp M. , Rizas Konstantinos , Theiss Hans , Braun Daniel , Orban Martin , Peterß Sven , Hausleiter Jörg , Massberg Steffen , Deseive Simon 
Published: December 2023

AbstractBackgroundPatients undergoing transcatheter aortic valve implantation (TAVI) frequently have coronary artery disease requiring percutaneous coronary intervention (PCI). Usually, PCI and TAVI are performed in two separate procedures and current studies are investigating potential benefits regarding the order. However, the two interventions may also be performed simultaneously, thereby limiting the risk associated with repeated vascular access. Data evaluating benefit and harm of concomitant procedures are scarce.AimsTherefore, this study aimed to evaluate concomitant PCI (coPCI) in TAVI patients regarding Valve Academic Research Consortium 3 (VARC‐3) endpoints and long‐term mortality.MethodsA total of 2233 consecutive TAVI patients from the EVERY‐VALVE registry were analyzed according to the VARC‐3 endpoint definitions. A total of 274 patients had undergone TAVI and concomitant PCI (coPCI group). They were compared to 226 TAVI patients who had received PCI within 60 days before TAVI in a stepwise approach (swPCI group) and to the remaining 1733 TAVI patients who had not undergone PCI recently (noPCI group).ResultsOverall median age was 81.4 years, median Society of Thoracic Surgeons score was 4.0%. Patients in the coPCI and in the swPCI group were predominantly male with reduced left‐ventricular ejection fraction. Rates of VARC‐3 composite endpoints technical success and 30‐day device success were comparable between all three groups. Mortality rates at 3 years after TAVI were similar (coPCI, 34.2% vs. swPCI, 31.9% vs. noPCI, 34.0% p = 0.84).ConclusionscoPCI during TAVI seems comparable in a retrospective analysis. Compared to a stepwise approach, it has similar rates of composite endpoints technical success and device success as well as long‐term mortality.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids triggered by Hodgkin's lymphoma: A case report and brief literature review
Authors: Shervedani Atiyeh Karimi , Tabibian Farinaz , Khotbesara Mahdiyeh Gholipour , Adibi Iman 
Published: December 2023

Key Clinical MessageWe presented a patient, diagnosed with lymphoma‐associated CLIPPERS, 11 years after lymphoma treatment. Therefore, CLIPPERS may be paraneoplastic neurological syndrome of lymphoma, which needs to be considered in the follow‐up of lymphoma cases.AbstractChronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system disorder with a recent increase in incidence. There are few reports of lymphoma‐associated CLIPPERS, although the relationship between these two diseases and the pathophysiology of CLIPPERS in general need further investigation. Here, we present a patient with a history of Hodgkin's lymphoma (HL) more than 10 years before the onset of CLIPPERS, in contrast to the majority of previously reported lymphoma‐associated cases, and discuss the possibility that CLIPPERS is the paraneoplastic neurological syndrome of HL. This highlights the need to consider CLIPPERS as a differential diagnosis during follow‐up of patients with a history of lymphoma.