bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of B0$$ {\mathrm{B}}_0 $$ field imperfections correction on BOLD sensitivity in 3D‐SPARKLING fMRI data
Authors: Amor Zaineb , Le Ster Caroline , GR Chaithya , Daval‐Frérot Guillaume , Boulant Nicolas , Mauconduit Franck , Thirion Bertrand , Ciuciu Philippe , Vignaud Alexandre 
Published: December 2023

AbstractPurposeStatic and dynamic field imperfections are detrimental to functional MRI (fMRI) applications, especially at ultra‐high magnetic fields (UHF). In this work, a field camera is used to assess the benefits of retrospectively correcting field perturbations on Blood Oxygen Level Dependent (BOLD) sensitivity in non‐Cartesian three‐dimensional (3D)‐SPARKLING fMRI acquisitions.MethodsfMRI data were acquired at 1 mm and for a 2.4s‐TR while concurrently monitoring in real‐time field perturbations using a Skope Clip‐on field camera in a novel experimental setting involving a shorter TR than the required minimal TR of the field probes. Measurements of the dynamic field deviations were used along with a static map to retrospectively correct static and dynamic field imperfections, respectively. In order to evaluate the impact of such a correction on fMRI volumes, a comparative study was conducted on healthy volunteers.ResultsCorrection of deviations improved image quality and yielded between 20% and 30% increase in median temporal signal‐to‐noise ratio (tSNR).Using fMRI data collected during a retinotopic mapping experiment, we demonstrated a significant increase in sensitivity to the BOLD contrast and improved accuracy of the BOLD phase maps: 44% (resp., 159%) more activated voxels were retrieved when using a significance control level based on a p‐value of 0.001 without correcting for multiple comparisons (resp., 0.05 with a false discovery rate correction).Conclusion3D‐SPARKLING fMRI hugely benefits from static and dynamic imperfections correction. However, the proposed experimental protocol is flexible enough to be deployed on a large spectrum of encoding schemes, including arbitrary non‐Cartesian readouts.
Tensor‐valued diffusion MRI of human acute stroke
Authors: Zhou Mi , Stobbe Robert , Szczepankiewicz Filip , Budde Matthew , Buck Brian , Kate Mahesh , Lloret Mar , Fairall Paige , Butcher Ken , Shuaib Ashfaq , Emery Derek , Nilsson Markus , Westin Carl‐Fredrik , Beaulieu Christian 
Published: December 2023

AbstractPurposeTensor‐valued diffusion encoding can disentangle orientation dispersion and subvoxel anisotropy, potentially offering insight into microstructural changes after cerebral ischemia. The purpose was to evaluate tensor‐valued diffusion MRI in human acute ischemic stroke, assess potential confounders from diffusion time dependencies, and compare to Monte Carlo diffusion simulations of axon beading.MethodsLinear (LTE) and spherical (STE) b‐tensor encoding with inherently different effective diffusion times were acquired in 21 acute ischemic stroke patients between 3 and 57 h post‐onset at 3 T in 2.5 min. In an additional 10 patients, STE with 2 LTE yielding different effective diffusion times were acquired for comparison. Diffusional variance decomposition (DIVIDE) was used to estimate microscopic anisotropy (μFA), as well as anisotropic, isotropic, and total diffusional variance (MKA, MKI, MKT). DIVIDE parameters, and diffusion tensor imaging (DTI)‐derived mean diffusivity and fractional anisotropy (FA) were compared in lesion versus contralateral white matter. Monte Carlo diffusion simulations of various cylindrical geometries for all b‐tensor protocols were used to interpret parameter measurements.ResultsMD was ˜40% lower in lesions for all LTE/STE protocols. The DIVIDE parameters varied with effective diffusion time: higher μFA and MKA in lesion versus contralateral white matter for STE with longer effective diffusion time LTE, whereas the shorter effective diffusion time LTE protocol yielded lower μFA and MKA in lesions. Both protocols, regardless of diffusion time, were consistent with simulations of greater beading amplitude and intracellular volume fraction.ConclusionDIVIDE parameters depend on diffusion time in acute stroke but consistently indicate neurite beading and larger intracellular volume fraction.
Mitigating slice cross‐talk in multi‐slice multi‐echo spin echo T2 mapping
Authors: Brui Ekaterina A. , Badrieva Zilya , de Mayenne Charles‐Alexis , Rapacchi Stanislas , Troalen Thomas , Bendahan David 
Published: December 2023

AbstractPurposeTo investigate whether a T2 inter‐slice variation could occur when a multi‐slice multi‐echo spin echo (MESE) sequence is used for image acquisition and to propose an enhanced method for reconstructing T2 maps that can effectively address and correct these variations.MethodsBloch simulations were performed accounting for the direct saturation effect to evaluate magnetization changes in multi‐slice 2D MESE sequence. Experimental phantom scans were performed to validate these simulations. An improved version of the dictionary‐based reconstruction approach was proposed, enabling the creation of a multi‐slice dictionary of echo modulation curves (EMC). The corresponding method has been assayed considering inter‐slice T2 variation with phantoms and in lower leg.ResultsExperimental and numerical study illustrate that direct saturation leads to a bias of EMCs. This bias during the T2 maps reconstructions using original single‐slice EMC‐dictionary method led to inter‐slice T2 variation of 2.03% in average coefficient of variation (CV) in agarose phantoms, and up to 2.8% in vivo (for TR = 2 s, slice gap = 0%). A reduction of CV was observed when increasing the gap up to 100% (0.36% in phantoms, and up to 1.5% in vivo) or increasing TR up to 4 s (0.76% in phantoms, and up to 1.9% in vivo). Matching the multi‐slice experimental data with multi‐slice dictionaries provided a reduced CV of 0.54% in phantoms and up to 2.3% in vivo.ConclusionT2 values quantified from multi‐slice MESE images using single‐slice dictionaries are biased. A dedicated multi‐slice EMC method providing the appropriate dictionaries can reduce the inter‐slice T2 variation.
The clinical and genetic landscape of early‐onset thrombophilia in Japan
Authors: Egami Naoki , Ishimura Masataka , Ochiai Masayuki , Ichiyama Masako , Inoue Hirosuke , Suenobu Souichi , Nishikubo Toshiya , Nogami Keiji , Ishiguro Akira , Hotta Taeko , Uchiumi Takeshi , Kang Dongchon , Ohga Shouichi 
Published: December 2023

AbstractObjectivesTo determine the optimal management for early‐onset thrombophilia (EOT), the genetic and clinical features of protein C (PC)‐, protein S (PS)‐, or antithrombin (AT)‐deficient patients of ≤20 years of age were studied in Japan.Methods/resultsClinical and genetic information of all genetically diagnosed cases was collected through the prospective, retrospective study, and literature review. One‐hundred‐one patients had PC (n = 55), PS (n = 29), or AT deficiency (n = 18). One overlapping case had PC‐ and PS‐monoallelic variant. Fifty‐five PC‐deficient patients (54%) had 26 monoallelic or 29 biallelic variant(s), and 29 (29%) PS‐deficient patients had 20 monoallelic or nine biallelic variant(s). None of the patients had AT‐biallelic variants. The frequent low‐risk allele p.K193del (PC‐Tottori) was found in five patients with monoallelic (19%) but not 29 with biallelic variant(s). The most common low‐risk allele p.K196E (PS‐Tokushima) was found in five with monoallelic (25%) and six with biallelic variant(s) (67%). One exceptional de novo PC variant was found in 32 families with EOT. Only five parents had a history of thromboembolism. Thrombosis concurrently developed in three mother–newborn pairs (two PC deficiency and one AT deficiency). The prospective cohort revealed the outcomes of 35 patients: three deaths with PC deficiency and 20 complication‐free survivors. Neurological complications were more frequently found in patients with PC‐biallelic variants than those with PC‐, PS‐, or AT‐monoallelic variants (73% vs. 24%, p = .019).ConclusionsWe demonstrate the need for elective screening for EOT targeting PC deficiency in Japan. Early prenatal diagnosis of PC deficiency in mother–infant pairs may prevent perinatal thrombosis in them.
Oncology mental health providers' adaptation of an evidence‐based intervention: A mixed‐methods study
Authors: Conley Claire C. , Ryba Marlena M. , Brothers Brittany M. , Lo Stephen B. , Andersen Barbara L. 
Published: December 2023

AbstractBackgroundAdaptations are intentional modifications maximizing the fit of an evidence‐based intervention (EBI) in new context. Little is known about EBI adaptation within psychosocial oncology. Guided by the Framework for Reporting Adaptations and Modifications‐Enhanced (FRAME), this mixed‐methods study describes oncology mental health providers' planned adaptations to a psychosocial oncology EBI and examines the relationship between planned adaptations and longitudinal EBI usage.MethodsProviders (N = 128) were social workers (47%) and psychologists (40%) practicing in community settings (44%) or academic medical centers (41%). They attended a 3‐day training on a multicomponent psychosocial oncology EBI, the Biobehavioral Intervention (BBI). During training, providers prepared an “adaptation plan” describing necessary adaptations to BBI and rationales for change. Qualitative data from adaptation plans were analyzed using directed content analysis. Linear mixed models examined the relationship between adaptation characteristics (number, similarity to the manualized BBI) and EBI usage across 12 months post‐training.ResultsThree sets of qualitative themes reflecting FRAME elements emerged: (1) content modifications (e.g., shortening/condensing, selecting elements, adding/removing elements); (2) contextual changes (e.g., alternative group formats); and (3) reasons for adaptations (e.g., organization/setting, provider, and recipient factors). Neither number of adaptations nor adaptation similarity were associated with BBI usage across 12 months post‐training.ConclusionsTo our knowledge, this study is the first to characterize oncology mental health providers' planned adaptations to a psychosocial oncology EBI. Planned adaptations did not increase usage, but importantly they did not decrease usage. The adaptation process enabled providers to make thoughtful adaptation choices, with implementation successful irrespective of setting constraints.
Pediatric systemic juvenile idiopathic arthritis‐related lung disease: Description of clinical cohort and review of management
Authors: Swanson Chandra , Khan Erin K. , Cooper Ashley , Ibarra Maria , Tam‐Williams Jade 
Published: December 2023

AbstractContextSince the early 2010s, there has been an increased awareness of interstitial lung disease in systemic juvenile idiopathic arthritis (sJIA‐LD) in pediatric patients. Despite the increase in prevalence of sJIA‐LD, little is known about this disease process and effective therapeutic management.ObjectivesTo identify and characterize the disease process and management of interstitial lung disease related to systemic juvenile idiopathic arthritis.Study DesignIn this single‐center, retrospective case series of 9 patients, we analyze demographic, clinical, radiographic, and laboratory data to corroborate common clinical characteristics and describe an approach for diagnosis and monitoring of sJIA‐LD.Data ExtractionAll data was extracted through electronic medical records and individually reviewed by two pediatric pulmonologists and two pediatric rheumatologists.ResultsOur results were similar to other described cases of sJIA‐LD as patients in our cohort were more likely to be younger, have a history of macrophage activation syndrome and prior use of biologic therapies. In contrast to prior studies, they did not present with peripheral lymphadenopathy and hepatosplenomegaly.LimitationsThe cohort size was small and data is reflective of one center's approach to management of a rare lung disease process.ConclusionInterstitial lung disease due to sJIA is rare and management can be difficult in these complex patients.More research is necessary to understand the increased incidence and treatment of sJIA‐LD in pediatric population.
Nonfragile containment control of nonlinear multi‐agent systems via a disturbance observer‐based approach
Authors: Zhou Tuo , Liu Quanli , Wang Wei 
Published: December 2023

AbstractIn this article, we consider the nonfragile containment control problem of nonlinear multi‐agent systems (MASs) with exogenous disturbance where the communication links among agents under consideration is directed. Firstly, based on relative output measurements between the agent and its neighbors, a disturbance observer‐based control protocol is proposed to solve the containment control problem of MASs with inherent nonlinear dynamics and exogenous disturbances. Secondly, because of the additional tuning of parameters in the real control systems, uncertainties in the designing of observer and controller gains always occur, and as a result, an output feedback controller with disturbance rejection is conceived and the containment control problem of nonlinear MASs with nonfragility is thoroughly investigated. Then, depending on matrix transformation and inequality technique, sufficient conditions of the designed controller gains exist, which is derived from the asymptotic stability analysis problem of some containment error dynamics of MASs. Finally, two simulation examples are exploited to illustrate the effectiveness of the proposed techniques.
Amplifying circular technological innovation for low greenhouse emissions: Empirical evidence from 30 advanced and emerging economies
Authors: Erdiaw‐Kwasie Michael Odei , Owusu‐Ansah Kofi Kusi , Abunyewah Matthew 
Published: December 2023

AbstractThis paper aims to examine the causal effect of circular technological innovation on greenhouse gas emissions. In the study, panel data are collected from 30 advanced and emerging economies spanning more than two decades, and a recently innovated instrumental variable approach with a common factor error structure is used to analyze dynamic panel data. The results provide robust findings during sensitivity tests. We find that technological innovation in a circular economy causes a significant reduction in major greenhouse gas emissions, including carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O). Since the net effects of circular technological innovation translate into a reduction of emissions, this appears as a suitable tool in the fight against climate change. In addition, our study highlights the need to reinforce measures to promote circular technological innovation to influence environmental quality, compared to viewing it as an alternative approach to environmental sustainability.
Dipole–Dipole Tuned Electronic Reconfiguration of Defective Carbon Sites for Efficient Oxygen Reduction into H2O2
Authors: Su Jiaxin , Jiang Lei , Xiao Bingbing , Liu Zixian , Wang Heng , Zhu Yongfa , Wang Jun , Zhu Xiaofeng 
Published: December 2023

AbstractMetal‐free carbon‐based materials are one of the most promising electrocatalysts toward 2‐electron oxygen reduction reaction (2e‐ORR) for on‐site production of hydrogen peroxide (H2O2), which however suffer from uncontrollable carbonizations and inferior 2e‐ORR selectivity. To this end, a polydopamine (PDA)‐modified carbon catalyst with a dipole–dipole enhancement is developed via a calcination‐free method. The H2O2 yield rate outstandingly reaches 1.8 mol gcat−1 h−1 with high faradaic efficiency of above 95% under a wide potential range of 0.4–0.7 VRHE, overwhelming most of carbon electrocatalysts. Meanwhile, within a lab‐made flow cell, the synthesized ORR electrode features an exceptional stability for over 250 h, achieved a pure H2O2 production efficacy of 306 g kWh−1. By virtue of its industrial‐level capabilities, the established flow cell manages to perform a rapid pulp bleaching within 30 min. The superior performance and enhanced selectivity of 2e‐ORR is experimentally revealed and attributed to the electronic reconfiguration on defective carbon sites induced by non‐covalent dipole–dipole influence between PDA and carbon, thereby prohibiting the cleavage of O–O in OOH intermediates. This proposed strategy of dipole–dipole effects is universally applicable over 1D carbon nanotubes and 2D graphene, providing a practical route to design 2e‐ORR catalysts.
TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis
Authors: Wang Lan , Zhao Wenyu , Xia Cong , Ma Shuaichen , Li Zhongzheng , Wang Ningdan , Ding Linke , Wang Yaxuan , Cheng Lianhui , Liu Huibing , Yang Juntang , Li Yajun , Rosas Ivan , Yu Guoying 
Published: December 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is a fatal and devastating lung disease of unknown etiology, described as the result of multiple cycles of epithelial cell injury and fibroblast activation. Despite this impressive increase in understanding, a therapy that reverses this form of fibrosis remains elusive. In our previous study, we found that miR-29b has a therapeutic effect on pulmonary fibrosis. However, its anti-fibrotic mechanism is not yet clear. Recently, our study identified that F-Actin Binding Protein (TRIOBP) is one of the target genes of miR-29b and found that deficiency of TRIOBP increases resistance to lung fibrosis in vivo. TRIOBP knockdown inhibited the proliferation of epithelial cells and attenuated the activation of fibroblasts. In addition, deficiency of Trio Rho Guanine Nucleotide Exchange Factor (TRIO) in epithelial cells and fibroblasts decreases susceptibility to lung fibrosis. TRIOBP interacting with TRIO promoted abnormal epithelial–mesenchymal crosstalk and modulated the nucleocytoplasmic translocation of β-catenin. We concluded that the miR-29b‒TRIOBP–TRIO–β-catenin axis might be a key anti-fibrotic axis in IPF to regulate lung regeneration and fibrosis, which may provide a promising treatment strategy for lung fibrosis.
Graphical Abstract
The role of beta-adrenoreceptors in postoperative ileus in rats
Authors: Marcin Bitel , Katarzyna Sztormowska-Achranowicz , Ivan Kocić 
Published: December 2023

AbstractThe aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following abdominal surgery in rat model of postoperative ileus. Bowel motility was measured by the intestinal transit of Evans blue introduced via orogastric tube after surgical procedures of skin incision, laparotomy and laparotomy with gut manipulation. Male rats were given individual adrenergic receptor subtypes antagonists intraperitoneally, and the influence of administered agents on intestinal transit of Evans blue was then evaluated. No statistically significant differences in the length of intestine in tested rats were observed. Propranolol administered prior to surgical procedure has shown protective effect on Evans blue migration in rats undergoing laparotomy and gut manipulation. Intestinal dye transit for propranolol doses of 10, 30 and 45 mg/kg was 18.00 ± 1.88c m, 23.75 ± 1.71 cm and 22.5 ± 2.43 cm, respectively, and for last two doses, statistically significant increase of dye passage was noted, compared to Evans blue transit of 11.00 ± 2.43 cm in the control group. No acceleration of dye migration was seen following administration of beta1-, beta2- and beta3-selective adrenergic receptor antagonist metoprolol, ICI 118.551 and SR58894A, respectively. Our research confirmed that propranolol at high doses, as seen by other researchers, improved bowel motility in early phase of postoperative ileus. That slight acceleration of intestinal dye transit after surgery with gut manipulation is rather connected with membrane-stabilizing action, than the receptor blocking effect, as this effect was not observed after the application of selective antagonists of respective subtypes of beta-adrenergic receptor.
A novel single nucleotide mutation of TFL1 alters the plant architecture of Gossypium arboreum through changing the pre-mRNA splicing
Authors: Liu Ji , Miao Pengfei , Qin Wenqiang , Hu Wei , Wei Zhenzhen , Ding Wusi , Zhang Huan , Wang Zhi 
Published: December 2023

Abstract
Key message
A single nucleotide mutation from G to A at the 201st position changed the 5′ splice site and deleted 31 amino acids in the first exon of GaTFL1.

Abstract
Growth habit is an important agronomic trait that plays a decisive role in the plant architecture and crop yield. Cotton (Gossypium) tends to indeterminate growth, which is unsuitable for the once-over mechanical harvest system. Here, we identified a determinate growth mutant (dt1) in Gossypium arboreum by EMS mutagenesis, in which the main axis was terminated with the shoot apical meristem (SAM) converted into flowers. The map-based cloning of the dt1 locus showed a single nucleotide mutation from G to A at the 201st positions in TERMINAL FLOWER 1 (GaTFL1), which changed the alternative RNA 5′ splice site and resulted in 31 amino acids deletion and loss of function of GaTFL1. Comparative transcriptomic RNA-Seq analysis identified many transporters responsible for the phytohormones, auxin, sugar, and flavonoids, which may function downstream of GaTFL1 to involve the plant architecture regulation. These findings indicate a novel alternative splicing mechanism involved in the post-transcriptional modification and TFL1 may function upstream of the auxin and sugar pathways through mediating their transport to determine the SAM fate and coordinate the vegetative and reproductive development from the SAM of the plant, which provides clues for the TFL1 mechanism in plant development regulation and provide research strategies for plant architecture improvement.
In silico prediction and in vitro assessment of novel heterocyclics with antimalarial activity
Authors: Orozco Martha Ilce , Moreno Pedro , Guevara Miguel , Abonia Rodrigo , Quiroga Jairo , Insuasty Braulio , Barreto Mauricio , Burbano Maria Elena , Crespo-Ortiz Maria del Pilar 
Published: December 2023

AbstractThe development of new antimalarials is paramount to keep the goals on reduction of malaria cases in endemic regions. The search for quality hits has been challenging as many inhibitory molecules may not progress to the next development stage. The aim of this work was to screen an in-house library of heterocyclic compounds (HCUV) for antimalarial activity combining computational predictions and phenotypic techniques to find quality hits. The physicochemical determinants, pharmacokinetic properties (ADME), and drug-likeness of HCUV were evaluated in silico, and compounds were selected for structure-based virtual screening and in vitro analysis. Seven Plasmodium target proteins were selected from the DrugBank Database, and ligands and receptors were processed using UCSF Chimera and Open Babel before being subjected to docking using Autodock Vina and Autodock 4. Growth inhibition of P. falciparum (3D7) cultures was tested by SYBR Green assays, and toxicity was assessed using hemolytic activity tests and the Galleria mellonella in vivo model. From a total of 792 compounds, 341 with good ADME properties, drug-likeness, and no interference structures were subjected to in vitro analysis. Eight compounds showed IC50 ranging from 0.175 to 0.990 µM, and active compounds included pyridyl-diaminopyrimido-diazepines, pyridyl-N-acetyl- and pyridyl-N-phenyl-pyrazoline derivatives. The most potent compound (UV802, IC50 0.178 µM) showed no toxicophoric and was predicted to interact with P. falciparum 1-cysperoxidredoxin (PfPrx1). For the remaining 7 hits (IC50 < 1 μM), 3 showed in silico binding to PfPrx1, one was predicted to bind the haloacid dehalogenase-like hydrolase and plasmepsin II, and one interacted with the plasmodial heat shock protein 90.