bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resultados funcionales y radiológicos de osteotomía varizante de fémur para el manejo del genu valgo en esqueleto maduro
Authors: Tapia Angamarca Jéssica , Villarroel Rovere Hugo 
Published: January 2024

El genu valgo, se define como la deficiencia en el eje anatómico femorotibial más allá de los 6-8° del valgo fisiológico, y se caracteriza por un desplazamiento del eje mecánico hacia el compartimento lateral. Las osteotomías varizantes son una alternativa en pacientes con genu valgo sintomáticos, en el cual tras realizar la osteotomía, el eje de carga es trasladado al compartimento medial sano, reduciendo los síntomas y retrasando o previniendo la necesidad de una artroplastia. El objetivo del estudio es demostrar los resultados funcionales aplicando la escala Knee Society Score (KSS) y radiológicos, obtenidos en la corrección del genu valgo, mediante osteotomía varizante de fémur distal en pacientes con esqueleto maduro. Se presenta esta serie de casos en las Jornadas Médicas del Hospital Alcívar.
Artrodesis de rodilla y alargamiento de la extremidad con el sistema de fijación externa LRS en pacientes con fracaso de prótesis de rodilla
Authors: Apolinario R Luis , Villarroel Rovere Hugo 
Published: January 2024

La artrodesis de rodilla y alargamiento de la extremidad con el sistema de fijación externa "Orthofix Limb Reconstruction System™ (LRS)" en pacientes con fracaso de prótesis de rodilla es un procedimiento de salvamento en personas con rodillas no reconstruibles, con pérdidas masivas de tejidos, infección, inmunodeficiencia, lesiones irreparables del mecanismo extensor y en la artroplastia de rodilla fallida. El aflojamiento aséptico destaca como la principal causa de fracaso en las artroplastias de rodilla, la infección protésica continua con una incidencia del 1-20 %. El objetivo del present estudio fue evaluar la efectividad, seguridad y resultados funcionales a largo plazo de la artrodesis y alargamiento de la extremidad utilizando el fijador externo LRS en pacientes con fallo de la prótesis de rodilla. Estudio presentado en el congreso Anual de las Jornadas Médicas del Hospital Alcívar.
Factors affecting complication rates of Pneumonectomy in destroyed lung
Authors: Muhammad Imran  , Jawad Hameed  , Asif Ahmed  , Aysha Mairaj  , Samar Naeem  , Abdul Baseer  
Published: January 2024

Objective: to investigate the relationship between the characteristics of patients who underwent pneumonectomy for destroyed lung and the surgical procedures employed and factors that affect postoperative complications.
Methodology: Study was completed at Lady reading hospital, Peshawar from February 2022 to January 2023 in duration of one year. A total of 60 patients enrolled in the study who were underwent pneumonectomy for destroyed lung. Main variables of study were risk factors like smoking, hypertension, diabetes and tuberculosis. Pathological findings and complications. SPSS version 27 was used for data analysis.
Results: The mean FEV1 of the patients was 1.53±0.45%. The mean albumin of the patients was 3.51±0.68 g/dL. The mean hemoglobin of the patients was 11.86±1.34 (g/dL). The mean lactate dehydrogenase of the patients was 185.31±11.62 U/L. There were 36.7% patients who had right lung affected and 63.3% patients who had left lung affected. The most common pathological findings were bronchiectasis 53.3% and granulomatous inflammation 35.0%. Whereas, the most common postoperative complications were empyema and bleeding in10 (16.7%) patients.
Conclusion
Patients who undergo surgical resection for a destroyed lung face an elevated risk of postoperative complications if they exhibit low albumin levels. Despite this association, it is advisable not to preclude pneumonectomy as a surgical treatment option for eligible patients with destroyed lung.
Pelatihan Kerajinan Tangan di Panti Asuhan ‘Aisyiyah Ampang
Authors: Davit Davit 
Published: January 2024

The visit of Aisyiyah Orphanage in Ramadan is part of the activity social held by the academy. Aisyiyah Orphanage is an institution that accommodating children who are disadvantaged and need extra attention in meet daily needs and education. The purpose of this activity is to build a sense of responsibility from members of Scientific SMEs to remain solid in every activity. The methods carried out are the planning stage, the implementation stage, and the evaluation stage.
PENGARUH MUTASI DAN KOMPENSASI TERHADAP KINERJA PEGAWAI DI RSUD BATARA GURU KABUPATEN LUWU
Authors: Masda Masda , Salju Salju , Risal Risal 
Published: January 2024

ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh mutasi terhadap kinerja pegawai di Rumah Sakit Umum Daerah Batara Guru Kabupaten Luwu, mengetahui pengaruh kompensasi terhadap kinerja pegawai di Rumah Sakit Umum Daerah Batara Guru Kabupaten Luwu, mengetahui pengaruh mutasi dan kompensasi secara simultan terhadap kinerja pegawai di Rumah Sakit Umum Daerah Batara Guru Kabupaten Luwu. Populasi sekaligus sampel yang dipilih dalam penelitian adalah semua pegawai dki RSUD Batara Guru Belopa sebanyak 65 orang, yang diambil menggunakan simple random sampling. Metode analisis data yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa mutasi berpengaruh signifikan terhadap kinerja pegawai di Rumah Sakit Umum Daerah Batara Guru Kabupaten Luwu, kompensasi berpengaruh signifikan terhadap kinerja pegawai di Rumah Sakit Umum Daerah Batara Guru Kabupaten Luwu, mutasi dan kompensasi secara simultan berpengaruh terhadap kinerja pegawai di Rumah Sakit Umum Daerah Batara Guru Kabupaten Luwu.

ABSTRAct
This study aims to determine the effect of mutation on employee performance at Batara Guru Regional General Hospital, Luwu Regency, determine the effect of compensation on employee performance at Batara Guru Regional General Hospital, Luwu Regency, determine the effect of mutation and compensation simultaneously on employee performance at Batara Guru Regional General Hospital, Luwu Regency. The population as well as the sample selected in the study were all employees of the Batara Guru Belopa Regional General Hospital as many as 65 people, who were taken using simple random sampling. The data analysis method used is multiple linear regression analysis. The results showed that mutation has a significant effect on employee performance at Batara Guru Regional General Hospital, Luwu Regency, compensation has a significant effect on employee performance at Batara Guru Regional General Hospital, Luwu Regency, mutation and compensation simultaneously affect employee performance at Batara Guru Regional General Hospital, Luwu Regency.
PENGARUH LINGKUNGAN KERJA DAN KERJASAMA TIM TERHADAP KINERJA KARYAWAN PAM TIRTA MANGKALUKU KOTA PALOPO
Authors: Rahayu Igha Rahma , Kusdarianto Indra , Sampetan Suparni 
Published: January 2024

ABSTRAK
Penelitian ini bertujuan untuk: (1) mengetahui pengaruh lingkungan kerja terhadap kinerja karyawan PAM Tirta Mangkaluku Kota Palopo, (2) mengetahuipengaruh kerjasama tim terhadap kinerja karyawan PAM Tirta Mangkaluku Kota Palopo, Populasi yang dipilih dalam penelitian adalah semua karyawan diPAM Tirta Mangkaluku Kota Palopo sebanyak 322 orang, peneliti mengambil sampel sebanyak 76 orang, dengan teknik pengambilan sampel purposive sampling. Metode analisis data yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa nilai t-hitunglingkungan kerja> t-tabel (7,477 > 1,666) dan signifikansi 0,000 < 0,05, dengan demikian lingkungan kerja signifikan dan berpengaruh positif terhadap kinerja karyawan PAM Tirta MangkalukuKota Palopo.Nilai t-hitung kerjasama tim > t- tabel (5,644 > 1,666) dan signifikansi 0,000 < 0,05, dengan demikian kerjasama tim signifikan dan berpengaruh signifikan terhadap kinerja karyawan PAM Tirta MangkalukuKota Palopo.
ABSTRAct
This study aims to: (1) determine the effect of the work environment on the performance of PAM Tirta Mangkaluku employees, Palopo City, (2) determine the effect of teamwork on the performance of PAM Tirta Mangkaluku employees, Palopo City. The population selected in this study were all employees of PAM Tirta Mangkaluku City. Palopo as many as 322 people, researchers took a sample of 76 people, with purposive sampling sampling technique. The data analysis method used is multiple linear regression analysis. The results showed that the t-count value of the work environment > t-table (7.477 > 1.666) and a significance of 0.000 <0.05, thus the work environment was significant and had a positive effect on the performance of PAM Tirta Mangkaluku employees, Palopo City. The t-count value of teamwork > t-table (5.644 > 1.666) and a significance of 0.000 <0.05, thus teamwork is significant and has a significant effect on the performance of PAM Tirta Mangkaluku employees, Palopo City.
MELATIH KETERAMPILAN BERBICARA SISWA SDN 20 RANTAU BAYUR MELALUI KEGIATAN MENDONGENG
Authors: Mayrita Hastari , Yanti Novri , Mawarni  , Novita Dinda , Anjani Devi , Andriani Margareta 
Published: January 2024

Keterampilan berbicara ini dapat mengekspresikan, mengemukakan pendapat, menyampaikan perasaan, gagasan, dan menyatakan. Terampilan berbicara di depan umum akan menambahkan rasa percaya diri seseorang. Tujuan pengabdian ini adalah untuk meningkatkan kemampuan berbicara dalam proses pembelajaran melalui dongeng pada siswa kelas 4 SD Negeri 20 Rantau Bayur. Berdasarkan observasi, satu siklus pertemuan didapatkan bahwa kurangnya minat baca bagi para siswa, selain itu kurangnya perlengkapan buku-buku yang menunjang kegiatan belajar mengajar. Oleh karena itu, melalui pengabdian ini, Tim melatih keterampilan mendongeng untuk para siswa tersebut
Sugar Cane Vinasse as a Renewable and Sustainable Feedstock for Lipid Production from Aspergillus Niger and Aspergillus flavus
Authors: Zaguini Renata Pinto Ferreira , Cansian Ana Bárbara Moulin , Machado Jane Karla de Faria Borges , Nardi Caroline Peters Pigatto De 
Published: January 2024

Background and Aims: In the search for sustainability and the use of renewable energies, biodiesel has stood out as a notable alternative to the growing energy demand of modern society. Microbial fat synthesis for lipids has been a possibility to produce this biofuel. In this context, the research work aimed to cultivate Aspergillus niger and Aspergillus flavus fungi in commercial and homemade broth, plus variable concentrations of sugarcane vinasse as a substrate to extract lipids produced using different extraction techniques and solvents.
Methodology: The fungi were grown in a commercial medium and a homemade one made with potato extract. After cultivation, they were submitted to two pre-treatments: the Bead Mill technique and the Ultrasound technique. The extraction of lipids produced in a commercial medium was performed via Soxhlet with a mixture of solvents. Therefore, the lipids produced in a homemade medium were extracted with the adapted Bligh-Dyer method.
Results: The species grew to the different culture media submitted, but the home culture medium increased the reproductive. The industrial residue proves to be a good alternative as a supplement to the culture medium, helping to reduce costs and preserve the environment. The extraction by Soxhlet showed satisfactory results when the fungi were grown in a commercial medium, with Aspergillus niger being extracted from the ethyl acetate solvent, obtaining a yield of 18.78%, and for A. flavus extracted with dichloromethane/methanol (9:1) and chloroform, bringing yield of 32.98% and 32%, respectively. Although extraction by Soxhlet showed some excellent results, extraction with the Bligh-Dyer method demonstrated better lipid fractions ranging from 25% to 67% and reduced energy expenditure, indicating a promising use, cost, and benefit.
Conclusion: Filamentous fungi of the genus Aspergillus can be used to produce biodiesel as they proliferate and can produce the same amount of lipids as a vegetable, which requires a much larger area of soil, for example.
Rapid Screening of Binding Constants by Calibrated Competitive 1H NMR Spectroscopy
Authors: Heath Richard E. , Dykes Graham M. , Fish Heather , Smith David K. 
Published: February 2003

AbstractA calibrated competitive NMR method has been developed that is appropriate for the rapid screening of binding constants. This method involves the initial characterisation of a receptor–substrate binding event for which the 1H NMR spectrum of a given receptor (calibrant) is modified by the substrate of interest at a range of concentrations. For all subsequent “unknown” receptors, Ka values are then determined by using a competition assay (in the presence of the calibrant receptor) by measuring a single standard 1H NMR spectrum. This enables a rapid assessment of the recognition properties of a library of potential receptors. Only the calibrant receptor needs to be NMR active, while the library of putative receptors, as well as the substrate, can be NMR silent. This method assumes the formation of complexes of 1:1 stoichiometry. To demonstrate this methodology, the binding of a number of crown ether type compounds with K+ ions has been studied. Comparison of the binding strengths obtained by using this approach with those in the literature shows excellent agreement. A range of new compounds that have recently been synthesised within our group has also been screened in order to illustrate how this approach can rapidly assess binding ability. This method has significance for chemists working in the fields of combinatorial receptor/substrate design and supramolecular chemistry as a means of rapid optimisation of binding strength.
Conformers of Gaseous Proline
Authors: Czinki Eszter , Császár Attila G. 
Published: February 2003

AbstractAccurate geometries, relative energies, rotational and quartic centrifugal distortion constants, dipole moments, harmonic vibrational frequencies, and infrared intensities were determined from ab initio electronic structure calculations for eighteen conformers of the neutral form of the amino acidL‐proline. Only four conformers have notable population at low and moderate temperature. The second most stable conformer is only 2±2 kJ mol−1above the global minimum, while the third and fourth conformers are nearly degenerate and have an excess energy of 7±2 kJ mol−1relative to the global minimum. All four conformers have one hydrogen bond: N⋅⋅⋅HO in the lower energy pair of conformers, and NH⋅⋅⋅O in the higher energy pair of conformers. The conformer pairs differ only in their ring puckering. The relative energies of the conformers include corrections for valence electron correlation, extrapolated to the complete basis set limit, as well as core correlation and relativistic effects. Structural features of the pyrrolidine ring of proline are discussed by using the concept of pseudorotation. The accurate rotational and quartic centrifugal distortion constants as well as the vibrational frequencies and infrared intensities should aid identification and characterization of the conformers ofL‐proline by rotational and vibrational spectroscopy, respectively. Bonding features ofL‐proline, especially intramolecular hydrogen bonds, were investigated by the atoms‐in‐molecules (AIM) technique.
A Computational Study of Regioselectivity in a Cyclodextrin‐Mediated Diels–Alder Reaction: Revelation of Site Selectivity and the Importance of Shallow Binding and Multiple Binding Modes
Authors: Li Wan‐Sheung , Chung Wen‐Sheng , Chao Ito 
Published: February 2003

AbstractThe use of a cyclodextrin⋅Diels–Alder transition structure complex (CD⋅TS) as a model in molecular dynamics simulations has enabled us to gain insight into the controlling factors in the cyclodextrin‐mediated Diels–Alder reaction of methyl‐p‐benzoquinone with isoprene. MD simulations were carried out with multiple binding configurations of the CD⋅TS (TS=meta‐TS, para‐TS) complexes at the top and bottom rims of β‐CD. We discovered that i) only shallow binding with the CD is necessary for the regioselectivity, and multiple binding geometries are possible; ii) the narrow bottom rim, with the primary hydroxyl groups, of the CD binds both regio‐TSs better than at the wider top rim (secondary hydroxyl groups), which was unexpected from the perspective of shape complementarity that governs the stability of most CD⋅guest complexes. Overall, the bottom rim of the CD exhibits higher regioisomer discrimination for the meta‐TS; iii) structural clustering analyses of the CD⋅TS configurations (sampled during MD simulations) have enabled us to evaluate the binding energies of the different binding configurations. The result indicates that there is a direct correlation between meta‐product selectivity and a higher number of binding configurations favoring the formation of the CD⋅meta‐TS complex. The main forces of stabilization in the CD⋅TS complexes are the van der Waals interactions when the TS is bound at the top rim. At the bottom rim, closer contacts between polar functional groups of the TS and CD have increased the importance of electrostatic interactions. We found that van der Waals, solvation, and torsional forces are less favorable for complexation at the bottom rim; however, this is compensated by large favorable electrostatic interactions. With insights obtained from the study of CD⋅TS complexes and MD simulations of the modified heptakis‐[6‐O‐(2‐hydroxy)propyl]‐β‐CD, we were able to explain why a low selectivity was observed when the Diels–Alder reaction was carried out in this modified CD. Two types of search method [Monte Carlo and multiple minimum (MCMM) and molecular dynamics (MD)] to explore and evaluate the different possible binding geometries of the TS within β‐CD, were discussed.
Synthesis of New Heterocyclic Fatty Compounds
Authors: Fürmeier Sandra , Metzger Jürgen O. 
Published: February 2003

AbstractThe terminal tetrazoles 1−5, the tetrazole analogues of the most important naturally occurring fatty acids, have been synthesized from fatty nitriles and completely characterized. The linear C12 bis(tetrazole) 6 was prepared and represents a valuable supplement to the previously known C2−C5 alkyl‐ and alkenyl‐linked bis(tetrazoles). The tetrazoles 1−6 were converted into the respective 1,3,4‐oxadiazoles 13−17 by heating in acetic anhydride. Three bis(oxadiazoles) 18−20 were also obtained. A 1,5‐disubstituted tetrazole 12 was synthesized from methyl 9(10)‐oxooctadecanoate by means of an improved Schmidt reaction. From methyl cis‐9,10‐epoxyoctadecanoate (21), various heterocycles such as the 4,5‐dihydrooxazoles 22, the oxazolidines 24, the imidazoles 26, the oxazoles 27, and the imidazolinethione 28 were prepared. Because of their structural relationship to the naturally occurring prostaglandins, compounds 12, 22, 24, 26, 27, and 28 should be of interest as homoprostanoids. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Joint patenting amongst companies ‒ exploring the effects of inter‐firm R&D partnering and experience
Authors: Hagedoorn John , Kranenburg Hans van , Osborn Richard N. 
Published: February 2003

AbstractR&D alliances and previous experience with the sharing of intellectual property rights are expected to have significant effects on joint patenting by alliance partners. Although so far un‐researched, this is both an intuitively and theoretically appealing subject because joint patenting could relate to the possible outcome of an important group of alliances. However, the main explanation for differences in joint patenting of R&D partners is found in their experience with the joint patenting process itself. Copyright © 2003 John Wiley & Sons, Ltd.
Transaction costs and capabilities as determinants of the R&D boundaries of the firm: a case study of the ten largest pharmaceutical firms in Japan
Authors: Odagiri Hiroyuki 
Published: February 2003

AbstractThe boundaries of the firm are an important issue in relation not just with the make‐or‐buy decision in production but also with research and development (R&D). Firms depend on universities to gain scientific knowledge, outsource some of their R&D works, purchase patented technologies, commission research, and participate in consortia. In this paper, we take the case of the 10 major pharmaceutical companies in Japan and show that they employ various types of research alliances with various partners, domestic or foreign. Two major theories to explain the boundaries, the transaction‐cost theory and the capability theory, are discussed and we argue that the observed pattern of research alliance is more consistent with the capability theory. Discussion is also made on the consortia and national projects these firms participate. Copyright © 2003 John Wiley & Sons, Ltd.
Test processes in software product evolution—a qualitative survey on the state of practice
Authors: Runeson Per , Andersson Carina , Höst Martin 
Published: February 2003

AbstractIn order to understand the state of test process practices in the software industry, we have conducted a qualitative survey, covering software development departments at 11 companies in Sweden of different sizes and application domains. The companies develop products in an evolutionary manner, which means either new versions are released regularly, or new product variants under new names are released. The survey was conducted through workshop and interview sessions, loosely guided by a questionnaire scheme.The main conclusions of the survey are that the documented development process is emphasized by larger organizations as a key asset, while smaller organizations tend to lean more on experienced people. Further, product volution is performed primarily as new product variants for embedded systems, and as new versions for packaged software. The development is structured using incremental development or a daily build approach; increments are used among more process‐focused organizations, and daily build is more frequently utilized in less process‐focused organizations. Test automation is performed using scripts for products with focus on functionality, and recorded data for products with focus on non‐functional properties. Test automation is an issue which most organizations want to improve; handling the legacy parts of the product and related documentation presents a common problem in improvement efforts for product evolution. Copyright © 2003 John Wiley & Sons, Ltd.
pathSCOUT™: exploration and
analysis of biochemical pathways
Authors: Minch E. , de Rinaldis M. , Weiss S. 
Published: February 2003

Abstract
Motivation: pathSCOUT™ provides access, display and exploration of data relevant to biochemical pathways, and enables analysis of pathway model structure and behavior.
Availability: pathSCOUT™ is available as a customized solution from contact@lionbioscience.com; limited evaluation access and additional information is available from http://simpath.lionbioscience.com:8080/documents/pathscout11/
Contact: eric.minch@lionbioscience.com
* To whom correspondence should be addressed.