bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genes ingenuity pathway analysis unveils smoothelin‐like 1 (SMTNL1) as a key regulatory protein involved in sodium pentobarbital‐induced growth inhibition in breast cancer
Authors: Li Bingwei , Zhang Xiaoyan , Liu Xueting , Li Ailing , Han Jianqun 
Published: November 2023

AbstractWe previously reported that sodium pentobarbital inhibited the growth of the breast cancer associated with the normalization of microcirculatory hemodynamics and oxygenation. Here, we aimed to screen the key regulatory proteins involved in pentobarbital‐induced normalization of microcirculatory hemodynamics in the breast cancer tissues. A nude mice model of xenograft was established using triple negative breast cancer cell line MDA‐MB‐231. After tumor cell implantation, the mice were subcutaneously injected with 50 mg/kg/day of sodium pentobarbital or an equal volume of solvent adjacent to the tumor for 14 days. Liquid chromatography linked to tandem mass spectrometry (LC–MS/MS) was used to analyze the difference in protein expression profile between the two groups. Ingenuity pathway analysis (IPA) was used to perform the canonical pathway analysis, upstream regulators analysis, and protein–protein interaction networks analysis. Screened proteins were confirmed by real‐time quantitative polymerase chain reaction (RT–qPCR) and Western blot analysis. A total of 101 differentially expressed proteins were revealed between groups. Canonical pathway analysis suggested that acute phase response signaling (z = 1, p = .00208), dilated cardiomyopathy signaling pathway (z = −2, p = .00671), and ILK signaling (z = 1, p = .0172) were key pathways with highlight associations. The mRNA and protein expressions of SMTNL1 were found significantly decreased in pentobarbital‐treated tumor tissues compared with those in controls (both p < .01). Nine important protein–protein interaction networks were identified, and of which, two contained multiple downstream regulatory proteins of SMTNL1. In conclusion, SMTNL1 is revealed as a key protein involved in pentobarbital‐induced growth inhibition signaling in breast cancer. SMTNL1 may become a new potential target for tumor microcirculation research.
Methyl eugenol aromatherapy: a delivery system facilitating the simultaneous application of male annihilation and sterile insect technique against the peach fruit fly
Authors: Rasool Awais , Fatima Sehar , Shah Said Hussain , Munis Muhammad Farooq Hussain , Irshad Afshan , Shelly Todd E. , Haq Ihsan ul 
Published: November 2023

AbstractBACKGROUNDThe peach fruit fly, Bactrocera zonata (Saunders) (Diptera: Tephritidae) is an economically important polyphagous, quarantine pest endemic to South and South‐East Asia. The male annihilation technique (MAT) and the sterile insect technique (SIT) are environmentally benign techniques used to suppress fruit fly populations on an area‐wide basis. The MAT and SIT are typically used sequentially to avoid killing released sterile males; however, MAT and SIT potentially could be used simultaneously and thereby increase the overall efficiency of control programmes. Mating competitiveness of sterile males against wild counterparts is critical for the success of the SIT. Feeding on a semiochemical, methyl eugenol (ME) has been reported to enhance the male mating performance of many Bactrocera spp., including B. zonata, but its use in SIT operational programmes is limited owing to the absence of a viable delivery system.RESULTSIn the present study, we demonstrated that ME aromatherapy, a practical method for large‐scale delivery of ME olfactorily, enhances the mating success of treated B. zonata males. ME aromatherapy application to 5‐day‐old immature males for a duration of 5 h resulted in increased mating success of males tested when sexually mature, compared to untreated males. The ME‐aromatized males also exhibited reduced attraction to ME‐lure.CONCLUSIONA practical delivery system for applying ME by aromatherapy to mass‐reared males was developed. ME‐aromatherapy enhanced male mating success and suppressed their subsequent attraction to ME, thus enabling the application of MAT and SIT at the same time. © 2023 Society of Chemical Industry.
An illness–death multistate model to implement delta adjustment and reference‐based imputation with time‐to‐event endpoints
Authors: García‐Hernandez Alberto , Pérez Teresa , del Carmen Pardo María , Rizopoulos Dimitris 
Published: November 2023

AbstractWith a treatment policy strategy, therapies are evaluated regardless of the disturbance caused by intercurrent events (ICEs). Implementing this estimand is challenging if subjects are not followed up after the ICE. This circumstance can be dealt with using delta adjustment (DA) or reference‐based (RB) imputation. In the survival field, DA and RB imputation have been researched so far using multiple imputation (MI). Here, we present a fully analytical solution. We use the illness–death multistate model with the following transitions: (a) from the initial state to the event of interest, (b) from the initial state to the ICE, and (c) from the ICE to the event. We estimate the intensity function of transitions (a) and (b) using flexible parametric survival models. Transition (c) is assumed unobserved but identifiable using DA or RB imputation assumptions. Various rules have been considered: no ICE effect, DA under proportional hazards (PH) or additive hazards (AH), jump to reference (J2R), and (either PH or AH) copy increment from reference. We obtain the marginal survival curve of interest by calculating, via numerical integration, the probability of transitioning from the initial state to the event of interest regardless of having passed or not by the ICE state. We use the delta method to obtain standard errors (SEs). Finally, we quantify the performance of the proposed estimator through simulations and compare it against MI. Our analytical solution is more efficient than MI and avoids SE misestimation—a known phenomenon associated with Rubin's variance equation.
Effect of estimation error on the conditional false alarm rate design of the EWMA chart
Authors: Haq Abdul , Woodall William H. 
Published: November 2023

AbstractIn this article, we study the effect of estimation error on the conditional false alarm rate (CFAR) of the exponentially weighted moving average (EWMA) chart based on the estimated dynamic probability control limits (EDPCLs). It is found that the effect is large, but with an increase in the Phase‐I sample size, the effect of estimation error may be reduced. In addition, an alternative approach is suggested for determining the EDPCLs for the EWMA chart that may help reduce the effect of estimation error on the CFAR profiles.
Nussbaum gain adaptive control for full‐state constrained cyber‐physical system under network attacks and actuator failures
Authors: Miao Baoling , Li Shu , Liu Lei 
Published: November 2023

AbstractIn this article, an adaptive security control scheme is proposed for a class of nonlinear time‐varying full‐state constrained cyber‐physical system with false data injection attacks and actuator failures. Aiming at the problem of sensor network attack, the influence of sensor network attack is reduced by backstepping technique and Nussbaum function. In the control design process, the time‐varying barrier Lyapunov function is used to constrain the system states. In addition, adaptive laws are designed to eliminate the influence of actuator faults (effectiveness loss and bias fault). And the developed controller ensures that the state constraints will not be violated when sensor attacks and actuator faults occur simultaneously. Finally, the simulation result verify the effectiveness of the scheme.
Sustainable development: Driving force from the relationship between finance inclusion, green finance and green growth
Authors: Oanh Tran Thi Kim 
Published: November 2023

AbstractThis paper studies sustainable development and its driving force—the linkage between financial inclusion, green finance and green growth in 14 low financial development countries (LFDCs) and 11 high financial development countries (HFDCs) from 2005 to 2019. Bayesian regression results show that when green finance is not taken into account, the probabilities that green GDP growth positively impacts sustainable development in HFDCs and LFDCs are 58.31% and 61.06%, respectively. The probability that financial inclusion positively impacts sustainable development in HFDCs is 88.34% and it is 100% in LFDCs. The interaction between green finance and financial inclusion positively impacts sustainable development in both groups of countries. In addition, this article also provides evidence that the rate of urbanization and trade openness positively affect sustainable development. In contrast, the rate of inflation and the population growth rate impact sustainable development negatively.
Fluorescent Carbon Dots from Snake Plant for Applications as Probe for Optical and Electrochemical Sensing of Hg2+ and Fe3+ and Bio‐Imaging Agent
Authors: Sharma Ankita , Kirti  , Kumari Alka , Srivastava Divesh N. , Paul Parimal 
Published: November 2023

AbstractFluorescent carbon dots (CD) have been synthesized from Dracaena trifasciata (snake plant) following a one‐step hydro‐thermal method and have been characterized on the basis of elemental analysis, XPS, PXRD, TGA, IR, Raman, UV–vis, fluorescence, AFM and HRTEM analysis. The performance of the CDs as probe for the metal ion(s) using optical and electrochemical techniques has been investigated. The fluorescence study suggested that these CDs selectively detect Hg2+ and Fe3+ with detection limits of 13 nM (2.6 ppb) and 12 nM (0.71 ppb), respectively. The electrochemical sensing of Hg2+ and Fe3+ has also been done using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), respectively, using CD coated Glassy Carbon Electrode (GCE) and the LoD value found for Hg2+ is 8 nM (0.45 ppb). The cytotoxicity test revealed that these CDs are non‐toxic and the bio‐imaging study exhibited that it penetrates into the bacterial and microalgal cell membrane showing good fluorescent image.
Recent Developments in Rongalite Chemistry: A Critical Review
Authors: Ali Rashid 
Published: November 2023

AbstractRongalite whose chemical structure was discovered in 1905, is an inexpensive, easily assessable, and copious industrial product, which has significantly been used for a long time in rubber, dye, and veterinary industries. Moreover, it has also been used as an antidote against several heavy metals poisoning, in addition to its applications in the photographic developer and veterinary medicines. Gratifyingly, Rongalite has also shown its uses as the fungicidal, bactericidal and antioxidant in pharmaceutical formulation. Besides, it has also been used in material sciences, and also as a viable cosmetic hair‐dye‐color removers. Interestingly, in past decade, it has shown its high‐impact in the arena of synthetic organic chemistry serving as SO22− equivalent, C1 synthon donor, reducing agent/radical initiator or proton source ‐ to assemble diverse intricate organic molecules under operationally simple yet efficient conditions. However, the services of multiple features of Rongalite in synthetic chemistry are still at the research stage, and needs to be sophisticated to a higher level in many years to come. Considering the synthetic importance of this valued reagent, this review article presents the advancement made in the field of Rongalite chemistry in the past three years. This review article will update the researchers working in this arena about the advancement of Rongalite in the synthetic organic transformations as well as it will help readers wishing to deal with this easy‐to handle and eco‐friendly low‐cost commodity chemical. This review article updating the rongalite chemistry will be useful to the chemical community in general and synthetic chemists in particular.
Does leader‐member exchange ambivalence hinder employee well‐being? Exploring relations with work engagement and emotional exhaustion
Authors: Han Yu , Sears Greg J. 
Published: November 2023

AbstractRecent research has introduced the concept of leader‐member exchange (LMX) ambivalence and has shown that it can be detrimental to employee task performance. Drawing on self‐determination theory and models of LMX development, this research investigates whether LMX ambivalence may also negatively influence employee well‐being. In a two‐wave field study with 278 employees in a large police organisation, we found that LMX ambivalence was significantly associated with two focal measures of work‐related well‐being: work engagement and emotional exhaustion, through its influence on psychological need fulfilment. Perceived positive meaning in work was found to buffer the negative effects of LMX ambivalence on psychological need fulfilment and well‐being. Overall, these results contribute to the occupational health literature by demonstrating that psychological need fulfilment helps explain why LMX ambivalence negatively affects work related well‐being outcomes and underscores the important role of positive meaning in work as a buffer for these relationships.
Untethered Microgrippers for Precision Medicine
Authors: Zhou Huaijuan , Zhang Shengchang , Liu Zijian , Chi Bowen , Li Jinhua , Wang Yilong 
Published: November 2023

AbstractMicrogrippers, a branch of micro/nanorobots, refer to motile miniaturized machines that are of a size in the range of several to hundreds of micrometers. Compared with tethered grippers or other microscopic diagnostic and surgical equipment, untethered microgrippers play an indispensable role in biomedical applications because of their characteristics such as miniaturized size, dexterous shape tranformation, and controllable motion, which enables the microgrippers to enter hard‐to‐reach regions to execute specific medical tasks for disease diagnosis and treatment. To date, numerous medical microgrippers are developed, and their potential in cell manipulation, targeted drug delivery, biopsy, and minimally invasive surgery are explored. To achieve controlled locomotion and efficient target‐oriented actions, the materials, size, microarchitecture, and morphology of microgrippers shall be deliberately designed. In this review, the authors summarizes the latest progress in untethered micrometer‐scale grippers. The working mechanisms of shape‐morphing and actuation methods for effective movement are first introduced. Then, the design principle and state‐of‐the‐art fabrication techniques of microgrippers are discussed. Finally, their applications in the precise medicine are highlighted, followed by offering future perspectives for the development of untethered medical microgrippers.
Ba4B14O25: A Deep Ultraviolet Transparent Nonlinear Optical Crystal with Strong Second Harmonic Generation Response Achieved by a Boron‐Rich Closed‐Loop Strategy
Authors: Xie Wei‐Jie , Tang Ru‐Ling , Yan Sheng‐Nan , Ma Nan , Hu Chun‐Li , Mao Jiang‐Gao 
Published: November 2023

AbstractDiscovering new deep ultraviolet (DUV) nonlinear optical (NLO) materials is the current research hotspot. However, how to perfectly integrate several stringent performances into a crystal is a great challenge because of the natural incompatibility among them, particularly wide band gap and large NLO coefficient. To tackle the challenge, a boron‐rich closed‐loop strategy is supposed, based on which a new barium borate, Ba4B14O25, is designed and synthesized successfully via the high‐temperature solid‐state melting method. It features a highly polymeric 3D geometry with the closed‐loop anionic framework [B14O25]8− constructed by the fundamental building blocks [B14O33]24−. The high‐density π‐conjugated [BO3]3− groups and the fully closed‐loop B–O–B connections make Ba4B14O25 possess excellent NLO properties, including short UV cutoff edge (<200 nm), large second harmonic generation response (3.0 × KDP) and phase‐matching capability, being a promising DUV‐transparent NLO candidate material. The work provides a creative design strategy for the exploration of DUV NLO crystals.
Change‐aware model checking for evolving concurrent programs based on Program Dependence Net
Authors: Li Shuo , Chen Cheng , Huang Zheng , Ding Zhijun 
Published: November 2023

SummaryConcurrent software needs to be maintained over time, and the differences between continuous versions tend to be localized. The expense that simply reapplying standard model checking techniques to the new version as they evolve may be infeasible. The existing methods reuse partial state‐space to reduce the scope. However, it is obviously costly to analyze on the explosive interleaving space of the evolving concurrent programs. The conservative change‐impact analysis methods without considering the specific property and leveraging the verified result from the prior version often results in exploring redundant state‐space irrelevant to this property. Moreover, the impact of the deleted elements needs to be analyzed on old version, and their impact needs to be mapped to new version, bringing some dispensable costs. In this paper, we propose a change‐aware model checking method based on program dependence net (PDNet) for linear temporal logic (LTL). We first propose an incremental modeling method to construct a PDNet of new version by modification rules. Then, we propose a reuse checking algorithm to judge whether the verified result can be reused based on the PDNet slice. Finally, we implement change‐aware model checking tool (DAMER) and validate the advantages of our methods.
Behind Johannesburg: Plants and Possible Futures in an Industrialized Hinterland
Authors: Sacks Ruth 
Published: November 2023

AbstractThis chapter explores two ubiquitous edible plants of Johannesburg’s hinterland by way of their cultivation: maize (a staple crop) and blackjack (an invasive species). Traversing wholescale maize production in the most industrialized hinterland in Africa, to the informal farming initiatives from inner city Johannesburg to its surrounds, how crops are grown and invasives are treated in different spaces point to toxic apartheid and colonial legacies. These include the stigmas attached to different categories of plants and how marginalized communities are forced to grow their own food and forage. Thinking with Johannesburg’s hinterland, and its ancient role of providing food for the city, maize and blackjack provide a way into considering possible food futures in the face of shortages and the climate crisis.
Pulling at the Thread
Authors: Jerolleman Alessandra , Marino Elizabeth , Jessee Nathan , Koslov Liz , Comardelle Chantel , Villarreal Melissa , de Vries Daniel , Manda Simon 
Published: November 2023

AbstractOver the last twenty years, the authors of this book have been enmeshed in conversations about how difficult it is to support communities as they plan relocations and resettlements as an adaptive response to climate change-related flooding. Twenty years ago in Alaska, relocation challenges seemed born of state ignorance and neglect.
Precarious Possessors and “the Right to (Rebuilding) the City”
Authors: Jerolleman Alessandra , Marino Elizabeth , Jessee Nathan , Koslov Liz , Comardelle Chantel , Villarreal Melissa , de Vries Daniel , Manda Simon 
Published: November 2023

AbstractThis chapter focuses on communities, groups, neighborhoods, individuals, classes of individuals, and families who have a precarious relationship with property. Here, we discuss the ways in which that relationship structures rights to imagine, access, and rebuild infrastructure and social life after a disaster and during processes of relocation as an adaptation to climate change—rights we collectively describe as “the right to rebuilding the city.”
Relations between scaling exponents in unimodular random graphs
Authors: Lee James R. 
Published: November 2023

AbstractWe investigate the validity of the “Einstein relations” in the general setting of unimodular random networks. These are equalities relating scaling exponents: $$\begin{aligned} d_{w} &= d_{f} + \tilde{\zeta }, \\ d_{s} &= 2 d_{f}/d_{w}, \end{aligned}$$ where dw is the walk dimension, df is the fractal dimension, ds is the spectral dimension, and $\tilde{\zeta }$ is the resistance exponent. Roughly speaking, this relates the mean displacement and return probability of a random walker to the density and conductivity of the underlying medium. We show that if df and $\tilde{\zeta } \geqslant 0$ exist, then dw and ds exist, and the aforementioned equalities hold. Moreover, our primary new estimate $d_{w} \geqslant d_{f} + \tilde{\zeta }$ is established for all $\tilde{\zeta } \in \mathbb{R}$.For the uniform infinite planar triangulation (UIPT), this yields the consequence dw=4 using df=4 (Angel in Geom. Funct. Anal. 13(5):935–974, 2003) and $\tilde{\zeta }=0$ (established here as a consequence of the Liouville Quantum Gravity theory, following Gwynne-Miller 2020 and (Ding and Gwynne in Commun. Math. Phys. 374(3):1877–1934, 2020)). The conclusion dw=4 had been previously established by Gwynne and Hutchcroft (2018) using more elaborate methods. A new consequence is that dw=df for the uniform infinite Schnyder-wood decorated triangulation, implying that the simple random walk is subdiffusive, since df>2.
An exploratory analysis of incentive packages and managerial performance
Authors: Alves Iryna , Lourenço Sofia M. 
Published: November 2023

AbstractThis study explores the interplay among different types of incentives (monetary incentives, non-monetary incentives, and benefits) and managerial performance. We collect data via a questionnaire and use qualitative comparative analysis (QCA) to analyze them. Using data from 614 managers, we identify multiple incentive packages that are consistently related to high managerial performance. Specifically, our analyses reveal that non-monetary incentives in the form of autonomy and development opportunities are as related to high performance in isolation as their combination with recognition. High performance can also be achieved with the combination of traditional tangible benefits with (1) social support benefits and recognition or with (2) monetary incentives. Finally, our findings suggest that monetary incentives, social benefits, and autonomy and development opportunities are more important for the success of CFOs than to non-CFOs. Conversely, tangible benefits are particularly relevant for the high performance of non-CFOs but not for CFOs. Our findings contribute to the incentives literature by showing successful incentive packages that companies are using in practice and how they relate to different theories such as agency theory, self-determination theory, and human capital theory.