bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process
Authors: Ganapathy Kavina , Pandey Sri Prakash , Bishnoi Sunita , Suriyaprakash Jagadeesh , Alarfaj Abdullah A. , Hirad Abdurahman Hajinur , Thangavelu Indumathi 
Published: February 2024

In recent years, the development of dual dopant‐based nanoparticles (NPs) has gained significant attention as they possess exceptional physico‐chemical and biomedical properties, making them potential candidates for antimicrobial and anticancer uses. In this research, we successfully synthesized nickel oxide (NiO) and copper, manganese‐doped NiO (CuMn:NiO) NPs using a green synthesis method. The synthesis process involved Trigonella foenum‐graecum (T.f.graecum) leaves extract as a nucleating agent. The synthesized nanoparticles were confirmed by various physico‐chemical studies. Based on X‐ray diffraction analysis, the median size was determined as 36 nm for NiO and 32 nm for CuMn:NiO NPs. The antibacterial study revealed that CuMn:NiO NPs exhibited a higher zone of inhibition in contrast to both Gram‐positive (Streptococcus pneumoniae, Bacillus subtilis, Bacillus megaterium) and Gram‐negative bacteria (Klebsiella pneumoniae, Escherichia coli, Vibrio cholerae) compared with NiO NPs and commercial amoxicillin. The antifungal studies conducted against Candida albicans demonstrated that CuMn:NiO NPs exhibited enhanced efficacy in comparison to NiO NPs. In vitro testing against human breast cancer cells (MCF‐7) demonstrated the anticancer potential of NiO and CuMn:NiO NPs, supported by IC50 concentrations of 11 and 9 μg/mL, respectively. The photoluminescence (PL) spectra of NiO and CuMn:NiO NPs exhibited a green emission at 508 and 518 nm, respectively, which indicated the generation of active free radicals by the NPs. These findings suggest that CuMn:NiO NPs hold promise in the healthcare industry.
Regional MRI volumetry using NeuroQuant versus visual rating scales in patients with cognitive impairment and dementia
Authors: Persson Karin , Barca Maria L. , Edwin Trine Holt , Cavallin‐Eklund Lena , Tangen Gro Gujord , Rhodius‐Meester Hanneke F. M. , Selbæk Geir , Knapskog Anne‐Brita , Engedal Knut 
Published: February 2024

AbstractBackground and purposeThe aims were to compare the novel regional brain volumetric measures derived by the automatic software NeuroQuant (NQ) with clinically used visual rating scales of medial temporal lobe atrophy (MTA), global cortical atrophy‐frontal (GCA‐f), and posterior atrophy (PA) brain regions, assessing their diagnostic validity, and to explore if combining automatic and visual methods would increase diagnostic prediction accuracy.MethodsBrain magnetic resonance imaging (MRI) examinations from 86 patients with subjective and mild cognitive impairment (i.e., non‐dementia, n = 41) and dementia (n = 45) from the Memory Clinic at Oslo University Hospital were assessed using NQ volumetry and with visual rating scales. Correlations, receiver operating characteristic analyses calculating area under the curves (AUCs) for diagnostic accuracy, and logistic regression analyses were performed.ResultsThe correlations between NQ volumetrics and visual ratings of corresponding regions were generally high between NQ hippocampi/temporal volumes and MTA (r = −0.72/−0.65) and between NQ frontal volume and GCA‐f (r = −0.62) but lower between NQ parietal/occipital volumes and PA (r = −0.49/−0.37).AUCs of each region, separating non‐dementia from dementia, were generally comparable between the two methods, except that NQ hippocampi volume did substantially better than visual MTA (AUC = 0.80 vs. 0.69). Combining both MRI methods increased only the explained variance of the diagnostic prediction substantially regarding the posterior brain region.ConclusionsThe findings of this study encourage the use of regional automatic volumetry in locations lacking neuroradiologists with experience in the rating of atrophy typical of neurodegenerative diseases, and in primary care settings.
Hydrogen bond interaction derived homogeneous graphene coating on submicron silicon anode
Authors: Li Liewu , Yang Yizhao , Huang Zhencheng , Huang Tao , Chen Weibin , Gong Xiaoyu , Ye Shenghua , Li Hao , Huang Shaoluan , Xiong Wei , Chen Jing , Wang Hongbin , Ren Xiangzhong , Ouyang Xiaoping , Wang Jionghui , Zhang Qianling , Hu Jiangtao , Liu Jianhong 
Published: February 2024

AbstractSilicon (Si) has emerged as a promising anode material in the pursuit of higher energy‐density lithium‐ion batteries (LIBs). The large‐scale applications of Si anode, however, are hindered by its significant swelling, severe pulverization, and continuous electrode–electrolyte reaction. Therefore, the development of an efficient approach to mitigate Si particle swelling and minimize interface parasitic reactions has emerged as a prominent research focus in both academia and industry. Here, a facile and scalable strategy is reported for the preparation of a double‐layer coated submicron Si anode, comprising ceramic (silicon oxide) and graphene layers, denoted as Si@SiOx@G. In this approach, SiOx is in situ synthesized on the surface of Si and bonded with graphene through hydrogen bond interactions. The prepared Si electrode shows exceptional structural integration and demonstrates outstanding electrochemical stability, with a capacity retention of 92.58% after 540 cycles at 1 A g−1, as well as remarkable rate capability, achieving a specific capacity of 875 mAh g−1 at 2 A g−1. This study presents a straightforward yet pragmatic approach for the widespread implementation of high‐energy‐density silicon‐based batteries.
Sex‐dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice
Authors: Baudo Gherardo , Flinn Hannah , Holcomb Morgan , Tiwari Anjana , Soriano Sirena , Taraballi Francesca , Godin Biana , Zinger Assaf , Villapol Sonia 
Published: February 2024

AbstractTraumatic brain injury (TBI) can have long‐lasting physical, emotional, and cognitive consequences due to the neurodegeneration caused by its robust inflammatory response. Despite advances in rehabilitation care, effective neuroprotective treatments for TBI patients are lacking. Furthermore, current drug delivery methods for TBI treatment are inefficient in targeting inflamed brain areas. To address this issue, we have developed a liposomal nanocarrier (Lipo) encapsulating dexamethasone (Dex), an agonist for the glucocorticoid receptor utilized to alleviate inflammation and swelling in various conditions. In vitro studies show that Lipo‐Dex were well tolerated in human and murine neural cells. Lipo‐Dex showed significant suppression of inflammatory cytokines, IL‐6 and TNF‐α, release after induction of neural inflammation with lipopolysaccharide. Further, the Lipo‐Dex were administered to young adult male and female C57BL/6 mice immediately after controlled cortical impact injury (a TBI model). Our findings demonstrate that Lipo‐Dex can selectively target the injured brain, thereby reducing lesion volume, cell death, astrogliosis, the release of pro‐inflammatory cytokines, and microglial activation compared to Lipo‐treated mice in a sex‐dependent manner, showing a major impact only in male mice. This highlights the importance of considering sex as a crucial variable in developing and evaluating new nano‐therapies for brain injury. These results suggest that Lipo‐Dex administration may effectively treat acute TBI.
Are YouTube videos about skull bone anatomy useful for students?
Authors: Cuglan Songul , Gas Selin 
Published: February 2024

AbstractThe aim of this study was to evaluate the content, quality, and functionality of YouTube videos on the anatomy of skull bones and to measure their educational usefulness. In this cross‐sectional study, the keywords “skull bones” and “skull anatomy” were searched in the YouTube search tab. Demographic data such as type, source, duration, upload date, and view rates of the videos were recorded. The quality and content of the videos were measured using the total content score (TCS), modified DISCERN scale, JAMA score, and Global Quality Scale (GQS). SPSS 26.0 software was used for statistical analysis. Twenty‐five (34.7%) of the first 72 videos found by keyword searches were included in the study. According to the GQS criteria, six of them (24%) were considered useful and 19 (76%) not useful. There was a strong statistically significant correlation between the GQS and DISCERN scores (r = 0.813, p < 0.001). There were strong statistically significant positive correlations between TCS and GQS scores (r = 0.887, p < 0.001) and between TCS and modified DISCERN scores (r = 0.691, p < 0.001). Additionally, there was a moderately strong statistically significant positive correlation between GQS and JAMA scores (r = 0.507, p < 0.05). There were also moderately strong statistically significant correlations between JAMA score and DISCERN score (r = 0.521, p < 0.001), video length (r = 0.416, p < 0.05), number of comments (r = 0.457, p < 0.05), and number of “likes” (r = 0.608, p < 0.001). There was a moderately strong statistically significant positive correlation between TCS and JAMA scores (r = 0.431, p < 0.05). Most YouTube videos have insufficient information about skull bones to meet the expectations of medical and dental school curricula. Anatomists and institutions should be encouraged to prepare and present YouTube videos using assessment systems such as DISCERN, JAMA, GQS, and TCS, in line with current anatomy curricula.
Genomic disparity impacts variant classification of cancer susceptibility genes in Turkish breast cancer patients
Authors: Agaoglu Nihat B. , Unal Busra , Hayes Connor P. , Walker McKenzie , Ng Ozden Hatirnaz , Doganay Levent , Can Nisan D. , Rana Huma Q. , Ghazani Arezou A. 
Published: February 2024

AbstractObjectiveTurkish genome is underrepresented in large genomic databases. This study aims to evaluate the effect of allele frequency in the Turkish population in determining the clinical utility of germline findings in breast cancer, including invasive lobular carcinoma (ILC), mixed invasive ductal and lobular carcinoma (IDC‐L), and ductal carcinoma (DC).MethodsTwo clinic‐based cohorts from the Umraniye Research and Training Hospital (URTH) were used in this study: a cohort consisting of 132 women with breast cancer and a non‐cancer cohort consisting of 492 participants. The evaluation of the germline landscape was performed by analysis of 27 cancer genes. The frequency and type of variants in the breast cancer cohort were compared to those in the non‐cancer cohort to investigate the effect of population genetics. The variant allele frequencies in Turkish Variome and gnomAD were statistically evaluated.ResultsThe genetic analysis identified 121 variants in the breast cancer cohort (actionable = 32, VUS = 89) and 223 variants in the non‐cancer cohort (actionable = 25, VUS = 188). The occurrence of 21 variants in both suggested a possible genetic population effect. Evaluation of allele frequency of 121 variants from the breast cancer cohort showed 22% had a significantly higher value in Turkish Variome compared to gnomAD (p < 0.0001, 95% CI) with a mean difference of 60 times (ranging from 1.37–354.4). After adjusting for variant allele frequency using the ancestry‐appropriate database, 6.7% (5/75) of VUS was reclassified to likely benign.ConclusionTo our knowledge, this is the first study of population genetic effects in breast cancer subtypes in Turkish women. Our findings underscore the need for a large genomic database representing Turkish population‐specific variants. It further highlights the significance of the ancestry‐appropriate population database for accurate variant assessment in clinical settings.
Delivery Strategies, Structural Modification, and Pharmacological Mechanisms of Honokiol: A Comprehensive Review
Authors: Pan Congying , Li Qing , Xiong Shuxin , Yang Yan , Yang Yi , Huang Chao , Wang Zhi‐Peng 
Published: February 2024

AbstractHonokiol (HK) is a traditional Chinese herbal bioactive compound that originates mainly from the Magnolia species, traditionally used to treat anxiety and stroke, as well as alleviation of flu symptoms. This natural product and its derivatives displayed diverse biological activities, including anticancer, antioxidant, anti‐inflammatory, neuroprotective, and antimicrobial activities. However, its poor bioavailability and pharmacological activity require primary consideration in the development of HK‐based drugs. Recent innovative HK formulations based on the nanotechnology approach allowed for improvement in both bioavailability and therapeutic efficacy. Chemical derivation and drug combination are also effective strategies to ameliorate the drawbacks of HK. In recent years, studies on HK derivatives and compositions have made great progress in the treatment of cancer, inflammation, bacterial infection, cardiovascular, and cerebrovascular diseases, demonstrating better activity than HK. The objective of this review is an examination of the recent developments in the field of pharmacological activity of HK and its drug‐related issues, and approaches to improve its physicochemical and biological properties, including solubility, stability, and bioavailability. Recent patents and the ongoing clinical trials in HK are also summarized.
Light‐off Performance of Three‐Way Catalysts Before and After Accelerated Aging Test with an Engine‐Dynamometer
Authors: Asakura Hiroyuki , Hosokawa Saburo , Miki Takeshi , Tanaka Tsunehiro 
Published: February 2024

AbstractThis study demonstrates the reaction behavior during the purification of model automotive exhaust gases over Pd catalysts before and after thermal degradation. In particular, to investigate the relationship between the Pd state and the reaction behavior of Pd/Al2O3 and Pd/CeO2−ZrO2 (CZ), operando X‐ray absorption spectroscopy measurements were performed during purifying exhaust gases over real and model catalysts mimicking the degradation of Pd particles and CZ supports after accelerated aging tests. The NO reduction activity of the aggregated Pd metal species was as high as that of the highly dispersed Pd species, but hydrocarbon (HC) poisoning was significantly enhanced by the aggregation of Pd metal particles caused by thermal aging. The existence of a three‐phase boundary (TPB) between the CZ, the Pd particles, and the gas phase strongly affected the catalytic activity at low temperatures, and the presence of a sufficient TPB facilitated the combustion of unburned HCs owing to the oxygen storage performance of CZ. Thus, the TPB reduced the poisoning of the precious metal surface by HC species at low temperatures. Therefore, the findings of this study will facilitate the development of next‐generation gas purification catalysts with high activity and durability.
Effect of wall thickness of 3D‐printed models on resisting deformation from thermal forming in‐office aligners
Authors: Bennett Gregory W. , DiGiovanni Tia 
Published: February 2024

AbstractBackgroundFabricating clear aligners by thermoforming three‐dimensional printed dental models requires a high degree of accuracy. It is unknown whether model thickness affects the accuracy when used to thermoform aligners.PurposeThis research utilizes three‐dimensional printed models made with differing wall thicknesses to determine its effect on their ability to withstand deformation during aligner fabrication.MethodsA total of 50 models of different wall thickness (10 each of 0.5, 1.0, 1.5, 2.0 mm, and solid) were printed using model resin (Model V2, Formlabs) on a low‐force stereolithography printer (Form 3B, Formlabs). Aligners were then fabricated using a thermal pressure forming machine (Biostar V, Great Lakes Dental Technologies) utilizing 25 s cycles to adapt 0.030″ acrylic sheets (Invisacryl, Great Lakes Dental Technologies), then removed from the models and sprayed with a contrast powder (Optispray, Dentsply Sirona) to aid in scanning with an intraoral scanner (CEREC Primescan, Dentsply Sirona). Each aligner's data was then compared to the original file used for printing with 3D comparison software (Geomagic Control X, 3D Systems).ResultsThe results show model thickness greater than or equal to 2.0 mm produced clinically acceptable results within the margin of error (0.3 mm). A total of 0.5 mm thickness failed to withstand thermal forming in 4 of the 10 trials. A total of 0.5 mm produced 27.56% of results in tolerance, 1.0 mm produced 75.66% of results in tolerance, 1.5 mm had 80.38% of results in tolerance, 86.82% of 2 mm models were in tolerance, and solid had 96.45% of results in tolerance.ConclusionHollow models of thicknesses 2.0 mm and solid models produced clinically acceptable aligners while utilizing less resin per unit compared to solid models, thus being more cost effective, time efficient and eco‐friendly. Therefore, a recommendation can be made to print hollow models with a shell thickness of greater than 2.0 mm for aligner fabrication.
Association of physical activity metrics with glucose variability in people with type 1 diabetes: A cross‐sectional study
Authors: Al Kandari Jumana , Al Ozairi Ebaa , Irshad Mohammad , Varghese Anisha , Gray Stuart R. 
Published: February 2024

AbstractThis study aims to investigate the association of physical activity metrics with measures of glucose variability in people with type 1 diabetes. From August 2019 to January 2022, people with type 1 diabetes, attending clinics or participating in ongoing research at the Dasman Diabetes Institute in Kuwait, were invited to participate in the study. Physical activity was measured over a 7‐day period using a wrist‐worn accelerometer, and glucose variability data were measured by continuous glucose monitoring (CGM) of the same period. Three hundred and eleven participants were recruited (age 33 (10) years, BMI 27(5) kg/m2 and n = 311 (169 female and 142 male)). Overall physical activity levels were not associated with any measure of glucose variability. The intensity gradient, which measures the distribution of physical activity intensity, was negatively associated with mean glucose (−1.01(−0.28, −1.74) and p = 0.007), CONGA (−1.00(−0.28, −1.72) and p = 0.007), J‐index (−11.7(−2.23, 21.2) and p = 0.016), HBGI (−2.73(−0.44, −5.02) and p = 0.020), GRADE (−2.27(−0.59, −3.95), p = 0.009) and GRADE – euglycaemia (−4.26(−0.46, −8.06) and p = 0–029) and the M‐value (−4.41 (−0.05, −8.77) and p = 0.049). Overall physical activity remains important, but it may be worth recommending people with type 1 diabetes to spend proportionately more of their day doing moderate to higher intensity physical activity, although this remains to be confirmed in an appropriately designed trial.
Incremental value relevancies in the development of reporting of sustainability performance
Authors: Donkor Augustine , Trireksani Terri , Djajadikerta Hadrian Geri 
Published: February 2024

AbstractSustainability reporting was introduced after financial reporting to meet the social and environmental informational needs of stakeholders, while integrated reporting was initiated to integrate financial reporting and sustainability reporting to advance the decision usefulness of corporate disclosure practices. Despite claims and evidence of the value relevance of each reporting framework exclusively, studies on the incremental value relevancies of these subsequent disclosure practices have been sparse. Using a sample of firms from the Johannesburg Stock Exchange from 2011 to 2020 and firms’ capital market liquidity performance, this study finds that sustainability reporting and integrated reporting are not only value‐relevant disclosure practices but also offer incremental value relevancies. Sustainability reporting provides incremental value relevance over financial reporting, and integrated reporting offers incremental value relevance over financial reporting and sustainability reporting. However, the findings do not find support for integrated reporting to replace the practices of financial reporting and sustainability reporting and affirm the contribution of each of the three reports in the corporate reporting space.
C‐peptide in diabetes: A player in a dual hormone disorder?
Authors: Dakroub Ali , Dbouk Ali , Asfour Aref , Nasser Suzanne A. , El‐Yazbi Ahmed F. , Sahebkar Amirhossein , Eid Assaad A. , Iratni Rabah , Eid Ali H. 
Published: February 2024

AbstractC‐peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C‐peptide serves an anti‐inflammatory and anti‐atherogenic role in type 1 diabetes mellitus (T1DM) and early T2DM. C‐peptide protects endothelial cells by activating AMP‐activated protein kinase α, thus suppressing the activity of NAD(P)H oxidase activity and reducing reactive oxygen species (ROS) generation. It also prevents apoptosis by regulating hyperglycemia‐induced p53 upregulation and mitochondrial adaptor p66shc overactivation, as well as reducing caspase‐3 activity and promoting expression of B‐cell lymphoma‐2. Additionally, C‐peptide suppresses platelet‐derived growth factor (PDGF)‐beta receptor and p44/p42 mitogen‐activated protein (MAP) kinase phosphorylation to inhibit vascular smooth muscle cells (VSMC) proliferation. It also diminishes leukocyte adhesion by virtue of its capacity to abolish nuclear factor kappa B (NF‐kB) signaling, a major pro‐inflammatory cascade. Consequently, it is envisaged that supplementation of C‐peptide in T1DM might ameliorate or even prevent end‐organ damage. In marked contrast, C‐peptide increases monocyte recruitment and migration through phosphoinositide 3‐kinase (PI‐3 kinase)‐mediated pathways, induces lipid accumulation via peroxisome proliferator‐activated receptor γ upregulation, and stimulates VSMC proliferation and CD4+ lymphocyte migration through Src‐kinase and PI‐3K dependent pathways. Thus, it promotes atherosclerosis and microvascular damage in late T2DM. Indeed, C‐peptide is now contemplated as a potential biomarker for insulin resistance in T2DM and linked to increased coronary artery disease risk. This shift in the understanding of the pathophysiology of diabetes from being a single hormone deficiency to a dual hormone disorder warrants a careful consideration of the role of C‐peptide as a unique molecule with promising diagnostic, prognostic, and therapeutic applications.
Analysis of flavor substances in Shaoxing traditional hand‐made Jiafan wine with different amounts of ZaoShao liquor
Authors: Peng Qi , Meng Kai , Yang Xinyi , Xu Zhuoqin , Zhang Lili , Zheng Huajun , Yu Hefeng , Zhang Yuhao , Xie Guangfa 
Published: February 2024

AbstractBACKGROUNDAdding ZaoShao liquor (high‐concentration liquor) is one of the most important steps in the brewing process of Shaoxing Jiafan wine, a product protected by Chinese geographical indications. The focus of this study is the effect of different additive amounts of liquor on the flavor of end products.RESULTSIn this study, four kinds of Shaoxing Jiafan wine were brewed by changing the amount of ZaoShao liquor. Headspace solid‐phase microextraction and gas chromatography–mass spectrometry were used to detect the flavor substances of four kinds of Jiafan wine. The difference in flavor of four kinds of Jiafan wine was evaluated by electronic nose analysis technology and verified by sensory evaluation. Finally, the reliability of the experimental results was verified through an aroma reconstruction experiment of rice wine. In this study, the differences in flavoring substances under different amounts of ZaoShao liquor were verified from various angles. The results showed that the flavors of the four kinds of wines were significantly different.CONCLUSIONThe composition of flavor substances in Shaoxing rice wine varies with the amount of ZaoShao liquor. This study provided a scientific basis for the improvement of production technology of Shaoxing wine. © 2024 Society of Chemical Industry.