bluuebunny/crossref_metadata_2025_split huggingface dataset:
An update on rehabilitative treatment of shoulder disease after breast cancer care
Authors: Ferrara P. E. , Gatto D. M. , Codazza S. , Zordan P. , Stefinlongo G. , Ariani M. , Coraci D. , Ronconi G. 
Published: December 2023

AbstractAccording to the latest statistics of the American Cancer Society 2022, breast cancer is a leading cause of morbidity and death among women worldwide. As a result of oncological procedures, breast cancer survivors often complain of pain and disability to the ipsilateral arm and shoulder. Objective: we aimed to analyze the latest literature regarding the efficacy of different rehabilitation treatments in patients affected by shoulder impairment secondary to breast cancer care. A comprehensive literature search was conducted on PubMed, PEDRO and Scopus databases. All English studies, published in the last decade up to March 2023, reporting shoulder problems in adult women treated for breast cancer with partial or total mastectomy ± breast reconstruction, lymphadenectomy, radio-, chemo-, hormonal or biologic therapy were assessed for eligibility. The methodological quality of the included trials was evaluated using the Cochrane bias tool. Of 159 articles identified, 26 were included in qualitative synthesis. Data from 1974 participants with a wide heterogeneity of breast cancer treatments were analyzed in this review. The methodological quality for most included studies was moderate. Several physiotherapy and interventional protocols showed some evidence of efficacy in shoulder range of motion (ROM), upper limb function, strength, pain and quality of life recovery after breast cancer treatment. Both physiotherapy alone or in combination with other techniques significantly improves shoulder disability, pain, and quality of life of patients undergoing breast cancer treatment regardless of their baseline characteristics or the time passed from surgery. The optimal treatment protocol and dosage remain unclear, and more homogeneous studies are needed in order to perform a meta-analysis of the literature.
Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
Authors: He Wenting , Chen Jieping , Zhou Yun , Deng Ting , Feng Yanling , Luo Xiaolin , Zhang Chuyao , Huang He , Liu Jihong 
Published: December 2023

Abstract
Background
Mitophagy is a process of selectively degrading damaged mitochondria, which has been found to be related to immunity, tumorigenesis, tumor progression, and metastasis. However, the role of mitophagy-related genes (MRGs) in the tumor microenvironment (TME) of ovarian cancer (OV) remains largely unexplored.

Methods
We analyzed the expression, prognosis, and genetic alterations of 29 MRGs in 480 OV samples. Unsupervised clustering was used to classify OV into two subtypes (clusters A and B) based on MRG changes. We compared the clinical features, differential expressed genes (DEGs), pathways, and immune cell infiltration between the two clusters. We constructed a mitophagy scoring system (MRG_score) based on the DEGs and validated its ability to predict overall survival of OV patients.

Results
We found that patients with high MRG_scores had better survival status and increased infiltration by immune cells. Further analysis showed that these patients may be more sensitive to immune checkpoint inhibitor (ICI) treatment. Additionally, the MRG_score significantly correlated with the sensitivity of chemotherapeutic drugs and targeted inhibitors.

Conclusion
Our comprehensive analysis of MRGs in the TME, clinical features, and patient prognosis revealed that the MRG_score is a potentially effective prognostic biomarker and predictor of treatment. This study provides new insights into the role of MRGs in OV and identifies patients who may benefit from ICI treatment, chemotherapy, or targeted treatment.
Random Raman Fiber Laser as a Liquid Refractive Index Sensor
Authors: Han Bing , Ma Yuxi , Wu Han , Zhao Yong 
Published: December 2023

AbstractIn this paper, a new concept of forward-pumped random Raman fiber laser (RRFL)-based liquid refractive index sensing is proposed for the first time. For liquid refractive index sensing, the flat fiber end immersed in the liquid can act as the point reflector for generating random fiber lasing and also as the sensing head. Due to the high sensitivity of the output power of the RRFL to the reflectivity provided by the point reflector in the ultralow reflectivity regime, the proposed RRFL is capable of achieving liquid refractive index sensing by measuring the random lasing output power. We theoretically investigate the effects of the operating pump power and fiber length on the refractive index sensitivity for the proposed RRFL. As a proof-of-concept demonstration, we experimentally realize high-sensitivity half-open short-cavity RRFL-based liquid refractive index sensing with the maximum sensitivity and the sensing resolution of–39.88W/RIU and 2.5075×10−5 RIU, respectively. We also experimentally verify that the refractive index sensitivity can be enhanced with the shorter fiber length of the RRFL. This work extends the application of the random fiber laser as a new platform for highly-sensitive refractive index sensing in chemical, biomedical, and environmental monitoring applications, etc.
Die Systemunterstützung in Niedersachsen während der Corona-Pandemie
Authors: Harfst Philipp , Franzmann Simon T. , Helmer Joschua , Kühnel Steffen M. 
Published: December 2023

ZusammenfassungIn diesem Beitrag analysieren wir die Systemunterstützung in Niedersachsen während der Corona-Pandemie. Die Unterstützung des politischen Systems hat eine große Bedeutung für die Stabilität und Zukunftsfähigkeit der repräsentativen Demokratie, die insbesondere im Zuge der Corona-Pandemie immer wieder als bedroht angesehen und zum Teil offen in Frage gestellt wurde. Auf der Basis der Daten des Niedersächsischen Demokratie-Monitors (NDM) prüfen wir, inwiefern insbesondere die Zufriedenheit unserer Befragten mit den Ergebnissen der Politik die Systemunterstützung prägen. Im Kontext der Corona-Pandemie, so unsere Annahme, sollte diese Unterstützung, wenn sie mit Politikergebnissen korreliert, stark von der Wahrnehmung der Corona-Maßnahmen von Bundes- und Landesregierung geprägt sein. Wir betrachten die Corona-Maßnahmen also als Spezialfall eines Policy-Outputs. Zudem untersuchen wir, ob es Unterschiede in der Bewertung der Bundes- und der Landesregierung und der von ihnen getroffenen Eindämmungsmaßnahmen gibt und ob diese Unterschiede in unterschiedlicher Weise auf die Systemunterstützung wirken. Im Ergebnis finden wir gemischte Evidenz für eine Wahlgewinner*innen-Hypothese. Stärkere Unterstützung in unseren Daten findet hingegen die Policy-Feedback-Hypothese, die auf Zufriedenheit mit den Corona-Maßnahmen abzielt. Zudem unterstützen AfD-Wähler*innen das politische System in deutlich geringerem Maße als die Wähler*innen aller anderen Parteien und Befragte mit populistischen Einstellungen sind erkennbar systemkritisch. Diese schwächere Systemunterstützung der Populist*innen wird im Fall der niedersächsischen Landesregierung – nicht jedoch im Fall der Bundesregierung – durch Zufriedenheit mit den Maßnahmen zur Eindämmung der Corona-Pandemie ausgeglichen.
Prevalence of vitamin E inadequacy, dietary intake and sources of alpha-tocopherol, and predictors of alpha- and gamma-tocopherol status in adolescent girls in Central Mozambique
Authors: Korkalo Liisa , Alfthan Georg , Fidalgo Lourdes , Freese Riitta I. 
Published: December 2023

Abstract
An adequate alpha-tocopherol status is important for females at reproductive age. We studied the dietary intake and sources of alpha-tocopherol and alpha- and gamma-tocopherol status indicators in 14–19-year-old girls in Central Mozambique. We also explored factors associated with alpha- and gamma-tocopherol status. The participants (n 508) were from the cross-sectional ZANE Study that was conducted in 2010. We recruited two separate samples, one in January–February and the other in May–June. We collected venous blood samples and conducted 24 h dietary recall interviews. At the time of blood sampling, 11 % of participants were pregnant and 10 % were lactating. In the total sample, both seasons combined, the median intake of alpha-tocopherol was 6⋅7 mg/d, the mean plasma alpha- and gamma-tocopherol concentrations were 13⋅5 and 0⋅75 μmol/l, respectively, and the prevalence of vitamin E inadequacy (alpha-tocopherol <12 μmol/l) was 36⋅7 % (95 % CI: 31⋅9–42⋅0 %). Season and lactation status were significant predictors of alpha-tocopherol status regardless of which the three indicators (plasma concentration, alpha-tocopherol:total cholesterol ratio, gamma-tocopherol:alpha-tocopherol ratio) were used. Being a lactating mother was negatively associated and having a blood sample taken in January–February, when the main sources of alpha-tocopherol were mango and dark green leafy vegetables, was positively associated with alpha-tocopherol status. In conclusion, vitamin E inadequacy was common in Central Mozambique, and the status may fluctuate due to seasonal changes in the diet. We suggest that lactating mothers are specifically at risk of poor alpha-tocopherol status in resource-poor settings.
Speed of extinction for continuous-state branching processes in a weakly subcritical Lévy environment
Authors: Cardona-Tobón Natalia , Pardo Juan Carlos 
Published: December 2023

AbstractWe continue with the systematic study of the speed of extinction of continuous-state branching processes in Lévy environments under more general branching mechanisms. Here, we deal with the weakly subcritical regime under the assumption that the branching mechanism is regularly varying. We extend recent results of Li and Xu (2018) and Palau et al. (2016), where it is assumed that the branching mechanism is stable, and complement the recent articles of Bansaye et al. (2021) and Cardona-Tobón and Pardo (2021), where the critical and the strongly and intermediate subcritical cases were treated, respectively. Our methodology combines a path analysis of the branching process together with its Lévy environment, fluctuation theory for Lévy processes, and the asymptotic behaviour of exponential functionals of Lévy processes. Our approach is inspired by the last two previously cited papers, and by Afanasyev et al. (2012), where the analogue was obtained.
The Influence of Country of Origin in the Process of Party Identification Acquisition
Authors: Castro Irizarry Giovanni 
Published: December 2023

AbstractThousands of Latin Americans migrate to the United States every year. This article seeks to understand how immigrants’ premigration political experiences influence the acquisition of party identification upon arrival in the United States. This research proposes that premigration political experiences influence the acquisition of party identification among Latino immigrants in the United States. Utilizing data from the 2016 Collaborative Multiracial Post-Election Survey (CMPS) and Proyecto Élites Parlamentarias Latinoamericanas (Latin American Parliamentary Elites Project), this paper analyzes how the ideology of the government in power in the immigrants’ country of origin influences party identification among Latino immigrants in the United States. Employing multinomial regression analysis, I demonstrate that the ideology of governments in power in Latin American countries when Latinos migrate influences the party identification of those immigrants in the United States. The results of this study contribute to the conversations on premigration experiences and challenge the applicability of classical theories of party identification for immigrants.
Leaf-litter frog abundance increases during succession of regenerating pastures
Authors: Thompson Michelle E. , Donnelly Maureen A. 
Published: December 2023

AbstractThe extensive clearing and modification of forests by anthropogenic activities is a major driver of biodiversity loss. Declines of common species are especially concerning because of the potentially large cascading effects they might have on ecosystems. Regrowth of secondary forests may help reverse population declines by restoring habitats to similar conditions prior to land conversion but the value of these secondary forests to fauna is not well understood. We compared the abundance of a direct-developing terrestrial frog,Craugastor stejnegerianus, in riparian and upland habitats of pasture, secondary forest, and mature forest sites. Mean abundance per transect was lower in upland pasture compared to mature forest. Secondary forest had similar abundance to mature forest regardless of age. We show that conversion of forest habitat to pasture represents a conservation threat to this species. However, riparian buffers help mitigate the negative effect of conversion of forest to pasture, and regrowth of secondary forest is an effective management strategy for restoring the abundance of this common leaf-litter species.
Banning Autonomous Weapons: A Legal and Ethical Mandate
Authors: O'Connell Mary Ellen 
Published: December 2023

AbstractChatGPT launched in November 2022, triggering a global debate on the use of artificial intelligence (AI). A debate on AI-enabled lethal autonomous weapon systems (LAWS) has been underway far longer. Two sides have emerged: one in favor and one opposed to an international law ban on LAWS. This essay explains the position of advocates of a ban without attempting to persuade opponents. Supporters of a ban believe LAWS are already unlawful and immoral to use without the need of a new treaty or protocol. They nevertheless seek an express prohibition to educate and publicize the threats these weapons pose. Foremost among their concerns is the “black box” problem. Programmers cannot know what a computer operating a weapons system empowered with AI will “learn” from the algorithm they use. They cannot know at the time of deployment if the system will comply with the prohibition on the use of force or the human right to life that applies in both war and peace. Even if they could, mechanized killing affronts human dignity. Ban supporters have long known that “AI models are not safe and no one knows how to reliably make them safe” or morally acceptable in taking human life.
Effects of in-store marketing on food and beverage purchases: a longitudinal study of households with children
Authors: Grummon Anna H , Petimar Joshua , Moran Alyssa J , Anderson Emma , Lurie Peter , John Sara , Rimm Eric B , Thorndike Anne N 
Published: December 2023

AbstractObjective:Most food retailers display foods in prominent locations as a marketing strategy (i.e. ‘placement promotions’). We examined the extent to which households with children change their food and beverage purchases in response to these promotions.Design:We analysed a novel dataset of all products promoted in two supermarkets from 2016 to 2017, including promotion dates and locations (e.g. aisle endcaps and front registers). We linked promotions to all purchases from the supermarkets from 2016 to 2017 by a cohort of households with children. We calculated the number of weekly promotions in each of thirteen food and beverage groups (e.g. bread; candy) and used fixed effects regressions to estimate associations between number of weekly promotions and households’ weekly food purchases, overall and by Supplemental Nutrition Assistance Program (SNAP) participation.Setting:Two large supermarkets in Maine, USA.Participants:Eight hundred and twenty-one households with children.Results:Most promotions (74 %) were for less healthy foods. The most promoted food groups were sweet and salty snacks (mean = 131·0 promotions/week), baked goods (mean = 68·2) and sugar-sweetened beverages (mean = 41·6). Households generally did not change their food group purchases during weeks when they were exposed to more promotions for those groups, except that a 1-sdincrease in endcap candy promotions (about 1 promotion/week) was associated with $0·19/week (about 14·5 %) increase in candy purchases among SNAP nonparticipants (adjustedP< 0·001).Conclusions:In-store placement promotions for food groups were generally not associated with purchases of promoted food groups, perhaps because exposure to unhealthy food marketing was consistently high. Substantial changes to in-store food marketing may be needed to promote healthier purchases.
ON RESIDUES AND CONJUGACIES FOR GERMS OF 1-D PARABOLIC DIFFEOMORPHISMS IN FINITE REGULARITY
Authors: Eynard-Bontemps Hélène , Navas Andrés 
Published: December 2023

AbstractWe study conjugacy classes of germs of nonflat diffeomorphisms of the real line fixing the origin. Based on the work of Takens and Yoccoz, we establish results that are sharp in terms of differentiability classes and order of tangency to the identity. The core of all of this lies in the invariance of residues under low-regular conjugacies. This may be seen as an extension of the fact (also proved in this article) that the value of the Schwarzian derivative at the origin for germs of
$C^3$
parabolic diffeomorphisms is invariant under
$C^2$
parabolic conjugacy, though it may vary arbitrarily under parabolic
$C^1$
conjugacy.
The protection of the natural environment in armed conflicts and agent-based modelling
Authors: Qandeel Mais 
Published: December 2023

AbstractThis article seeks to demonstrate the nexus between agent-related technology and the protection of the environment in armed conflicts, looking at how agent-based modelling and simulation (ABMS) can be used as a tool to protect the environment in armed conflicts. It further analyzes the precautionary principle and due regard, as relevant rules, and explains the legal benefits of deploying ABMS to protect and preserve the natural environment. The article argues that the deployment of ABMS helps States to better understand the environmental effects of conflicts, reassess their military activities and comply with the relevant applicable rules and norms.
Does Downscaling Improve the Performance of Urban Ozone Modeling?
Authors: Wang Yuting , Brasseur Guy P. , Ma Yong‐Feng , Peuch Vincent‐Henri , Wang Tao 
Published: December 2023

AbstractIncreasing the model resolution is expected to be one way for improving air quality forecasts in urban areas. In this study, we evaluate the model performance in a large city at various resolutions to examine the best resolution for air pollution simulations. The comparison with measurements at a station near the traffic emissions shows the advantage of using high resolutions for capturing the extreme values. The statistical evaluation indicates that the highest model resolution (33 m) provides the best results for NOX concentration distributions near the traffic roads, while the improvement for roadside O3 with decreasing grid spacing stops at a certain point. The best model performance for the areas with a distance to the pollution sources is with the resolution of 100–300 m, at which the transport errors are equivalent to the emission biases.
Mitochondrial nucleic acids in innate immunity and beyond
Authors: Yoon Jimin , Kim Sujin , Lee Mihye , Kim Yoosik 
Published: December 2023

AbstractMitochondria participate in a wide range of cellular processes. One essential function of mitochondria is to be a platform for antiviral signaling proteins during the innate immune response to viral infection. Recently, studies have revealed that mitochondrion-derived DNAs and RNAs are recognized as non-self molecules and act as immunogenic ligands. More importantly, the cytosolic release of these mitochondrial nucleic acids (mt-NAs) is closely associated with the pathogenesis of human diseases accompanying aberrant immune activation. The release of mitochondrial DNAs (mtDNAs) via BAX/BAK activation and/or VDAC1 oligomerization activates the innate immune response and inflammasome assembly. In addition, mitochondrial double-stranded RNAs (mt-dsRNAs) are sensed by pattern recognition receptors in the cytosol to induce type I interferon expression and initiate apoptotic programs. Notably, these cytosolic mt-NAs also mediate adipocyte differentiation and contribute to mitogenesis and mitochondrial thermogenesis. In this review, we summarize recent studies of innate immune signaling pathways regulated by mt-NAs, human diseases associated with mt-NAs, and the emerging physiological roles of mt-NAs.
The neural signature of psychomotor disturbance in depression
Authors: Wüthrich Florian , Lefebvre Stephanie , Mittal Vijay A. , Shankman Stewart A. , Alexander Nina , Brosch Katharina , Flinkenflügel Kira , Goltermann Janik , Grotegerd Dominik , Hahn Tim , Jamalabadi Hamidreza , Jansen Andreas , Leehr Elisabeth J. , Meinert Susanne , Nenadić Igor , Nitsch Robert , Stein Frederike , Straube Benjamin , Teutenberg Lea , Thiel Katharina , Thomas-Odenthal Florian , Usemann Paula , Winter Alexandra , Dannlowski Udo , Kircher Tilo , Walther Sebastian 
Published: December 2023

AbstractUp to 70% of patients with major depressive disorder present with psychomotor disturbance (PmD), but at the present time understanding of its pathophysiology is limited. In this study, we capitalized on a large sample of patients to examine the neural correlates of PmD in depression. This study included 820 healthy participants and 699 patients with remitted (n = 402) or current (n = 297) depression. Patients were further categorized as having psychomotor retardation, agitation, or no PmD. We compared resting-state functional connectivity (ROI-to-ROI) between nodes of the cerebral motor network between the groups, including primary motor cortex, supplementary motor area, sensory cortex, superior parietal lobe, caudate, putamen, pallidum, thalamus, and cerebellum. Additionally, we examined network topology of the motor network using graph theory. Among the currently depressed 55% had PmD (15% agitation, 29% retardation, and 11% concurrent agitation and retardation), while 16% of the remitted patients had PmD (8% retardation and 8% agitation). When compared with controls, currently depressed patients with PmD showed higher thalamo-cortical and pallido-cortical connectivity, but no network topology alterations. Currently depressed patients with retardation only had higher thalamo-cortical connectivity, while those with agitation had predominant higher pallido-cortical connectivity. Currently depressed patients without PmD showed higher thalamo-cortical, pallido-cortical, and cortico-cortical connectivity, as well as altered network topology compared to healthy controls. Remitted patients with PmD showed no differences in single connections but altered network topology, while remitted patients without PmD did not differ from healthy controls in any measure. We found evidence for compensatory increased cortico-cortical resting-state functional connectivity that may prevent psychomotor disturbance in current depression, but may perturb network topology. Agitation and retardation show specific connectivity signatures. Motor network topology is slightly altered in remitted patients arguing for persistent changes in depression. These alterations in functional connectivity may be addressed with non-invasive brain stimulation.