bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial
Authors: Vaccareza Maria Silvia , Paolini Paoletti Michele 
Published: December 2023

Albeit often overlapping, sin and vice are two related yet clearly distinguished concepts. It would require an extremely long detour to sketch the history of such thick, central notions in Western culture, as well as their similarities, differences, and overlappings. Sin is a polysemic notion. The word refers, primarily, to an action whereby an agent intentionally fails to live up to the will or commands of God (see Stump, 2018). However, sin can be also considered as a disposition of the will, i.e., an inclination to engage in sinful actions (Plantinga 2000). Finally, according to parts of the Christian tradition, sin is a metaphysical state, i.e., a condition of “uncleanness” which marks a fundamental ontological difference between human beings and God (M. Adams 1991, 20f). While according to the Christian thought vice can be a cause of sin, and a sinful disposition may closely resemble a vice, the two concepts shouldn’t be confused. First, while sin pertains to a theological vocabulary, talking of vices is perfectly compatible with a secular philosophical discourse, as the recent success of virtue ethics and virtue-vice epistemology testifies. This comes as no surprise, if one thinks that the very origin of the concept is rooted in the secular philosophical tradition tracing back to Plato and Aristotle. Secondly, within character-based moral and epistemic theories, a vice is, unequivocally, a trait of character. As such, it is part of an agent’s psychological makeup, which means that it is a stable feature of their moral psychology, independently of its specific behavioral manifestations. And while an action may well be vicious, it can be so only insofar as it springs from a vicious trait, which has—so to speak—ontogenetic, conceptual, and even normative priority over the actions it elicits.
Pourquoi le changement codique a une force créatrice
Authors: Holter Julia 
Published: December 2023

This essay proposes an example of literary code-switching from the modern period. The plans for three unfinished texts of Alexander Pushkin, “The Guests Were Arriving at the Dacha” (1828), “The Russian Pelham” (1834–1835), and “In the Waters of the Caucasus” (1831), abound with alternations between Russian and French, with some use of English and other languages. The current scholarly consensus is that Pushkin used the French language for planning, relying on its analytical features, and the Russian language, expressive but in need for renewal, as a language of textualization. The three fragments may represent a rare opportunity to see Pushkin’s bilingual creativity in action. I use Youri Lotman’s vision of code-switching as “auto-communication” on different channels (linguistic or not) to show how the ideas bouncing off the linguistic units belonging to different languages, but also sparking thanks to the mnemonic function of drawings, establish a current, a productive creative tension.
Innenentwicklung – eine realistische Strategie für die regionale Siedlungsflächenentwicklung?
Authors: Lütke-Daldrup Engelbert 
Published: December 2023

Angesichts der sich zuspitzenden Flächennutzungskonflikte in den Verdichtungsräumen intensiviert sich erneut die Debatte, wie das weitere Ausufern der Bebauung in das Weichbild der Städte gestoppt und die noch verbliebenen ökologisch bedeutsamen Freiräume geschützt werden können. Neben der eher langfristigen Perspektive sinkender Bevölkerungs- und Haushaltszahlen wird in absehbarer Zeit vor allem durch eine verstärkte Innenentwicklung eine Eindämmung des Landschaftsverbrauchs erwartet.Im Kontext einer rationalen, kontrollierten und den ökologischen Erfordernissen gerecht werdenden Flächenbewirtschaftung wird der Nutzung von Reserven im bereits besiedelten Raum strategische Bedeutung zugemessen. Inwieweit der zunächst noch auf jeden Fall verbleibende Expansionsbedarf der Kommunen durch Innenentwicklung aufgefangen werden kann, ist eine bisher ungeklärte Frage. Hierzu wird ein kleinräumiger Untersuchungsansatz zur Ermittlung, Analyse und Bewertung von Flächenpotentialen im Innenbereich vorgestellt.Die Ergebnisse einer Pilotstudie zur Innenentwicklung für den Umlandverband Frankfurt ermöglichen erste Aussagen zur Struktur und Größe der Flächenpotentiale. Zu den wesentlichen Ergebnissen gehört, daß die konkreten Gegebenheiten der Gebiete sowie die Veränderungsbedürfnisse und die finanziellen Möglichkeiten der Bewohner die tatsächliche Größe der Entwicklungsmöglichkeiten im Innenbereich determinieren.Bei Aufrechterhaltung des heute feststellbaren Flächenbedarfs wird in den prosperierenden Verdichtungsgebieten der weitere „Flächenverbrauch“ durch Innenentwicklung nicht zu stoppen sein. Solange weitreichende gesellschaftliche Verhaltensänderungen nicht absehbar sind, muß sich die Siedlungsplanung auf Expansionswünsche einstellen und versuchen, diese im Rahmen einer geordneten Flächenhaushaltspolitik rational zu steuern. Auf absehbare Zeit ist somit eine „mittlere Strategie“ mit verstärkter Innenentwicklung und begrenzter – ökologisch möglichst „unschädlicher“ – Außenentwicklung eine sinnvolle und realistische Orientierung der Planung.
Forschungs- und planungsorientierte Raumgliederungen mit VZ-Daten
Authors: Gatzweiler Hans-Peter 
Published: December 2023

Die in den nächsten Jahren zur Verfügung stehenden Regionaldaten aus den Großzählungen 1987 (Volkszählung, Arbeitsstättenzählung, Gebäude- und Wohnungszählung) dürften zu einer grundsätzlichen Fortschreibung von vorliegenden planungs- und forschungsorientierten Raumgliederungen führen.Dies gilt insbesondere für die Gebietskategorien der Raumordnung. Eine kritische Diskussion dieser Gebietskategorien kommt allerdings zu dem Ergebnis, daß sie sich überholt haben und ihre Neuabgrenzung wenig hilfreich erscheint. Generell sind detailliertere, problembezogene, empirische Analysen und Prognosen der räumlichen Entwicklung notwendig. Wünschenswert wäre, daß die amtliche Statistik aus den Großzählungen dafür ausreichend regional und sachlich differenzierte Daten bereitstellt.Gleichwohl sind aber Gebietstypisierungen für die Raumbeobachtung bzw. regionale Bestandsanalysen und Prognosen von grundsätzlicher analytischer Bedeutung. Sie haben die Funktion, wesentliche räumliche Unterschiede und Entwicklungen im Überblick darzustellen und die Diskussion von Unterschieden, Ursachen und Folgen und daraus zu ziehende Schlußfolgerungen zu erleichtern. Ausgehend von den siedlungsstrukturellen Gebietstypen der BfLR und in Anlehnung an Vorarbeiten des Arbeitskreises „Abgrenzung von Agglomerationsräumen“ der Akademie für Raumforschung und Landesplanung wird ein Konzept für ein integriertes räumliches Bezugssystem vorgeschlagen, das den Anforderungen der räumlich orientierten Planung und Forschung gleichermaßen Rechnung trägt. Die Umsetzung eines solchen Konzepts auf der Grundlage von Daten der Großzählungen 1987 sollte ein gemeinsames Anliegen von amtlicher und kommunaler Statistik sowie der räumlich orientierten Forschung sein.
The association of hematological inflammatory markers and psychological function in COVID‐19 patients: A cross‐sectional study
Authors: Khorasanchi Zahra , Rashidmayvan Mohammad , Hasanzadeh Elahe , Moghadam Mohammad Reza Shadmand Foumani , Afkhami Nafise , Asadiyan‐Sohan Parisa , Fard Mohammad Vahedi , Mohammadhasani Kimia , Varaste Naiemeh , Sharifan Payam , Ferns Gordon , Mobarhan Majid Ghayour 
Published: December 2023

AbstractMental health disorders are linked to systemic inflammation. Due to high inflammation and mental health disorders in COVID‐19 patients, we aimed to investigate the relationship between blood inflammatory markers such as red cell distribution width to platelet ratio (RPR), platelet‐lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), red cell distribution width (RDW), white blood cell (WBC), and psychological function in COVID‐19 patients. In the current cross‐sectional study, neuro‐psychological function, and a complete blood count (CBC) were measured on 120 COVID‐19 patients aged >30 years from the Imam Reza Hospital in Mashhad, Iran. Our results showed that anxiety related to MCHC (mean ± SD: 32.71 ± 1.68, p < 0.05), WBC (mean ± SD: 12.23 ± 5.43, p < 0.05), and PLR (median (IQR): 28.72 (15.88–41.31), p < 0.05) significantly. In the stress subgroup, only RPR was associated with stress (p < 0.05). Linear regression between hematological parameters and psychological score indicated that RDW and PLR had a significantly positive association with depression (β = 0.086; p = 0.045 and β = 1.326; p = 0.016, respectively) and anxiety scores (β = 0.100; p = 0.038 and β = 1.356; p = 0.010, respectively). Moreover, a positive correlation was found between PLR and stress (β = 1.102; p = 0.012). This study showed a positive association between depression/anxiety/stress symptoms and levels of hematological inflammatory markers including PLR and RDW. The findings of this study provide novel insights into mental health and physiological markers, underscoring the potential influence of inflammation on mood disorders. Our findings offer exciting prospects for future research and may lead to innovative approaches in the management and treatment of depression, anxiety, and stress.
A synchronic and diachronic reappraisal of Indo-European *dʱug̑ʱh2ter- ‘daughter’ and *suhxnú- ‘son’ in Celtic dialects, Insular and Continental
Authors: Hughes Art J. 
Published: December 2023

Abstract
This paper has two chief goals: (i) to collate the disparate synchronic evidence for the distribution of ‘daughter’ and ‘son’ from the dialect maps available for the modern Celtic languages, namely: the Gaelic languages (Irish, Scottish Gaelic and Manx) and Brittonic (Welsh, Cornish and Breton), (ii) to revisit and analyse the distribution of the terms ‘son’ and ‘daughter’ at an early stage of Continental Celtic from two millennia ago in Gaulish and Celt-Iberian with particular reference to the Indo-European lexemes *dʱug̑ʱh2ter ‘daughter’ and *suhxnú- ‘son’.
Silibinin reduces cell proliferation and migration via EMT pathway in TFK-1 cell line
Authors: Özel Yetkin Merve , Baskol Gulden 
Published: December 2023

Abstract

Objectives
Cholangiocarcinoma (CCA) is usually diagnosed at a late stage due to resistance to chemotherapeutic drugs. Epithelial mesenchymal transition (EMT) is a biological process in cancer that allows multiple biochemical changes that enable epithelial cells to acquire a mesenchymal phenotype. In the present study, we focused on the EMT process which is an important in carcinogenesis and metastatic progression, and also investigate the effect of silibinin on cell proliferation, colony formation, migration, apoptosis, cell cycle and EMT.

Methods
Cell viability, apoptosis and cell cycle were measured by Muse Cell Analyzer. All the protein levels were determined by ELISA method.

Results
We found that silibinin significantly reduced cell proliferation in a dose-dependent manner and the IC50 value was 200 μM. Silibinin, significantly inhibited colony formation, inhibited cell migration of cancer cells induced total apoptosis due to the induction of early and late apoptosis, arrest cancer cells in the G0/G1 phase of the cell cycle compared to the control group. We found that E-cadherin, N-cadherin, Vimentin and α-SMA protein levels were significantly decreased in the silibinin group compared to the control group.

Conclusions
Our results showed that silibinin could significantly prevent tumor proliferation, reduce colony formation, prevent migration, increase the arrest of the G0/G1 phase and induce apoptosis progress in human extracellular cholangiocarcinoma cell line. Another important data is that silibinin inhibits EMT in the cholangiocarcinoma cell line (TFK-1). Our study shows significant effects of silibinin in the TFK-1 cell line, which may be exciting to explore its implications in future animal studies.
Behavioral Validation of Individualized Low-Intensity Transcranial Electrical Stimulation (tES) Protocols
Authors: Joshi Rajat , Murali Sainath , Thirugnanasambandam Nivethida 
Published: December 2023

AbstractLarge interindividual variability in the effects of low-intensity transcranial electrical stimulation (tES) considerably limits its potential for clinical applications. It has been recently proposed that individualizing stimulation dose by accounting for interindividual anatomic differences would reduce the variability in electric fields (E-fields) over the targeted cortical site and therefore produce more consistent behavioral outcomes. However, improvement in behavioral outcomes following individualized dose tES has never been compared with that of conventional fixed dose tES. In this study, we aimed to empirically evaluate the effect of individualized dose tES on behavior and further compare it with the effects of sham and fixed dose stimulations. We conducted a single-blinded, sham-controlled, repeated-measures study to examine the impact of transcranial direct current stimulation on motor learning and that of transcranial alternating current stimulation on the working memory of 42 healthy adult individuals. Each participant underwent three sessions of tES, receiving fixed dose, individualized dose, or sham stimulation over the targeted brain region for the entire behavioral task. Our results showed that the individualized dose reduced the variability in E-fields at the targeted cortical surfaces. However, there was no significant effect of tES on behavioral outcomes. We argue that although the stimulation dose and E-field intensity at the targeted cortical site are linearly correlated, the effect of E-fields on behavior seems to be more complex. Effective optimization of tES protocols warrants further research considering both neuroanatomical and functional aspects of behavior.
Los diputados del Parlamento marroquí por las circunscripciones del Sahara Occidental y sus percepciones sobre el Majzen
Authors: Parejo Fernández María Angustias 
Published: December 2023

Este artículo ofrece un perfil de los parlamentarios por las circunscripciones del Sahara Occidental (2011-2016) y analiza sus percepciones y discursos sobre el Majzen. El desarrollo del trabajo nos permite validar en las conclusiones nuestras hipótesis de partida: la primera, la visión del Majzen de estos parlamentarios está permeada por una identidad regional limitada y condicionada por los márgenes autoritarios del régimen; la segunda, aunque estas élites periféricas aceptan participar en los procesos e instituciones estatales, sus percepciones sobre el Majzen no son unívocas y se derivan de la relación multisituada que mantienen con las líneas rojas del sistema.
Vaizduotė ir kūrybiškumas kaip kultūros vertybės Lietuvos gyventojų sąmonėje
Authors: Savicka Aida 
Published: December 2023

Imagination and creativity are emerging as human qualities that are seen as essential to finding new solutions to the challenges of the contemporary world. Recognizing that creativity is not only an individual, but also a communal trait, there is an increasing focus on creating a cultural and social environment that is conducive to creativity, where playfulness and imagination are valued, where freedom of expression is encouraged, and where openness to diversity and a tolerance for risk-taking and failure prevail. One of the fundamental elements of such an environment is the common societal perception that imagination is an important part of human activity. Using the data of the European Values Study, this article analyzes the attitude of Lithuanian society towards the importance of fostering of imagination, its socio-demographic differences and the dynamics of this attitude in 1990–2017.
Monte Carlo investigation of S-values for 111In radionuclide therapy
Authors: Jabbari Masoud , Pandesha S 
Published: December 2023

Novel therapeutic strategy in radionuclide therapy use cell-penetrating monoclonal antibodies to carry Auger-emitting radionuclides into the cells. Estimation of dose in normal and tumor cells are important to investigate the efficacy and toxicity of treatment. Monte Carlo simulation is the most suitable method for estimation of absorbed dose at microscopic level. It is therefore useful to carry out Monte Carlo simulation of Auger emitting radionuclides in order to assess the sensitivity of the results with respect to transport approximations generally used in Monte Carlo codes. There are several Auger emitting radionuclides with potential clinical applications, however, based on their half-life 111In is the most suitable for Auger therapeutic purposes and was considered in the present investigation. Geant4 Monte Carlo simulation was performed and specific absorbed dose fraction (or S-values) for 111In were calculated by using different physics model (Standard, Livermore, Penelope and Geant4-DNA) and compared with Medical Internal Radiation Dosimetry (MIRD) S-values. Source was distributed in the cytoplasm (Cy), surface (Cs) and nucleus (N). Average of relative differences (RD) (%) were calculated for self and cross absorbed dose. RD(%) for self-absorption (NßN) were 4.4, 2.36, 6.21 and 1.1 for Standard, Penelope, Livermore and Geant4-DNA respectively. For cross-absorption these values were higher (e.g. for NßCy 15.4, 18.36, 19.21 and 24.8 for Standard, Penelope, Livermore and Geant4-DNA respectively). Cutoff energy considered for electrons and gamma photons affect the results in dose estimation for Auger electrons in Monte Carlo simulation.
MYSTICAL DISCOURSE IN JAVA IN THE 18TH CENTURY NARRATED BY THE BOOK OF CABOLEK
Authors: Nasuhi Hamid 
Published: December 2023

This article discusses the discourse of Sufism in the 18th century in Java as narrated by Serat Cabolek by Kiai Yasadipura I (1729-1803). This manuscript tells about the trial of Kiai Ahmad Mutamakin in front of the authorities of the Mataram Kingdom in Kartasura. This cleric from the village of Cabolek, Tuban, in the northern coast of Java was controversial and accused of spreading Ilmu Hak, namely wujudiyah Sufism, to commoners, even though his knowledge capacity was considered inadequate by the religious scholars (ulama) who opposed him. In that trial Kiai Mutamakin was found guilty, but later was granted pardon by King Pakubuwana II (1726-1749). The author of Serat Cabolek not only recorded the chronological details of Kiai Mutamakin's trial, more than that he also emphasized his stance on how the Javanese should direct their religious orientation. Yasadipura I, as a court poet with educational background of pesantren (Islamic boarding school), figured Ketib Anom as an ideal Javanese Muslim. This religious head officer from Kudus is a figure that perfectly described not just having in-depth knowledge of traditional Javanese mysticism, namely the mystical story of Dewaruci, but also mastering and carrying out the provisions of the Shari'a in Islam.
Reconstrucción biológica de grandes defectos óseos con autoinjerto de peroné vascularizado en huesos largos
Authors: Jover Carbonell Pablo , Zarzuela Sánchez Víctor Manuel , Marín Bertolín Severiano , Marquina Moraleda Vicente , Martínez Bovaira Guillermo , Castillo Ruipérez Laura , Hernández Ferrando Lorenzo 
Published: December 2023

Introducción: El autoinjerto vascular de peroné se presenta como una muy buena opción en la reconstrucción de grandes defectos óseos en huesos largos gracias a sus características estructurales y propiedades biológicas.
Materiales y Métodos: Se realizó un estudio observacional descriptivo y retrospectivo que incluyó a todos los pacientes operados con un injerto vascular de peroné aislado o asociado a injerto estructural (técnica de Capanna) desde el 1 de enero de 2014 hasta el 1 de enero de 2021en nuestro hospital.
Resultados: Se realizaron 26 cirugías mediante un injerto vascular de peroné; en 8 de ellas, se utilizó el colgajo vascularizado de peroné para la reconstrucción del defecto óseo en hueso largo. El tamaño medio del defecto era de 7,7 cm. El origen del defecto era postraumático en 5 casos y tumoral en el resto. Se consiguió la consolidación completa en todos los pacientes. Los resultados clínicos y funcionales en las escalas de valoración fueron mejores en pacientes operados en el miembro inferior.
Conclusiones: El uso de un colgajo vascularizado de peroné asociado o no a aloinjerto estructural es una estrategia útil en la reconstrucción de grandes defectos óseos (≥5 cm), independientemente de la causa de la lesión; la supervivencia del injerto y la función son buenas, con una tasa de complicaciones aceptable.
Clasificación de Leonetti y Tigani para fracturas del pilón tibial: validación con residentes de Traumatología y Ortopedia, y fellows en tobillo y pie
Authors: Seletti Maximiliano , González Emanuel , Pendino Ana , Parma Julián , Derico Jeremías 
Published: December 2023

Objetivo: Validar la clasificación de Leonetti y Tigani con evaluadores de diferentes niveles de experiencia.
Materiales y Métodos: Se evaluó a 54 pacientes (54 fracturas del pilón tibial) en forma retrospectiva. Se tomaron radiografías de tibia distal, de frente y perfil, y una tomografía computarizada con cortes axiales, sagitales, coronales y reconstrucción 3D. Se incluyeron todos los subtipos de la clasificación de Leonetti y Tigani. Los evaluadores tenían diferentes niveles de entrenamientos: dos eran fellows en pie y tobillo, y dos, residentes del último año de formación. Para determinar la concordancia interobservador, cada caso fue clasificado en tipo I, II, III o IV, según Leonetti y Tigani. Para evaluar la concordancia intraobservador el mismo evaluador analizó los casos a las 6 semanas. Se utilizó el coeficiente kappa para determinar el grado de concordancia entre evaluadores y ese valor fue expresado con un intervalo de confianza del 95%.
Resultados: La concordancia intraobservador fue moderada y muy buena para cada fellow, y buena y muy buena para los residentes, entre la primera y segunda evaluación. La concordancia interobservador arrojó un coeficiente kappa global de 0,7156 (IC95% 0,60-0,83), un valor bueno cuando se consideraron todas las fracturas por todos los evaluadores.
Conclusiones: El sistema de clasificación de fracturas del pilón tibial alcanza concordancias superiores a las de estudios previos de otras clasificaciones. Dichas concordancias se lograron con médicos con diferentes niveles de experiencia y conocimiento. Nuestros hallazgos contribuyen a la validación externa e independiente de este nuevo sistema de clasificación.
Determinación del grado de agresividad tumoral mediante técnicas de inteligencia artificial aplicadas a imágenes de resonancia magnética
Authors: Segura Facundo , Segura Pablo , Segura Florencio 
Published: December 2023

Objetivo: Determinar el grado de agresividad tumoral mediante técnicas de inteligencia artificial utilizando imágenes de resonancia magnética de sarcomas con grado histológico comprobado.
Materiales y Métodos: Dos cohortes retrospectivas independientes de pacientes con sarcomas de partes blandas. Para cada paciente de las dos cohortes se adquirieron tres tipos de secuencias de imágenes como indican los protocolos clínicos: potenciadas en T1, en T2 con supresión grasa (T2FS) y STIR. A fin de desarrollar el modelo de inteligencia artificial, se utilizaron 134 imágenes, tanto las de alto grado como las de bajo grado, en T1 y T2 tomando la imagen más representativa del tumor en cualquier corte. Esto se traduce en 36 millones de píxeles que serán analizados por el programa Landing AI.
Resultados: La precisión promedio del modelo fue del 84,3% y la sensibilidad, del 73,3%, con un umbral de confianza de 0,66, lo que demuestra inicialmente que se obtuvo un modelo de buena calidad para predecir con imágenes de resonancia magnética el grado de agresividad de un sarcoma de partes blandas antes de la biopsia.
Conclusiones: Se presenta un enfoque novedoso para abordar un tipo de enfermedad infrecuente usando técnicas de inteligencia artificial para determinar el grado tumoral en imágenes de resonancia magnética. Según los resultados de nuestro modelo, se lo puede considerar como una segunda opinión experta al realizar los estudios por imágenes antes de la biopsia.