bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic signatures of selection, local adaptation and production type characterisation of East Adriatic sheep breeds
Authors: Lukic Boris , Curik Ino , Drzaic Ivana , Galić Vlatko , Shihabi Mario , Vostry Luboš , Cubric-Curik Vlatka 
Published: November 2023

AbstractBackgroundThe importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic migrations. Sheep production system is extensive and generally carried out in traditional systems without intensive systematic breeding programmes for high uniform trait production (carcass, wool and milk yield). Therefore, eight indigenous Croatian sheep breeds from eastern Adriatic treated here as metapopulation (EAS), are generally considered as multipurpose breeds (milk, meat and wool), not specialised for a particular type of production, but known for their robustness and resistance to certain environmental conditions. Our objective was to identify genomic regions and genes that exhibit patterns of positive selection signatures, decipher their biological and productive functionality, and provide a "genomic" characterization of EAS adaptation and determine its production type.ResultsWe identified positive selection signatures in EAS using several methods based on reduced local variation, linkage disequilibrium and site frequency spectrum (eROHi, iHS, nSL and CLR). Our analyses identified numerous genomic regions and genes (e.g., desmosomal cadherin and desmoglein gene families) associated with environmental adaptation and economically important traits. Most candidate genes were related to meat/production and health/immune response traits, while some of the candidate genes discovered were important for domestication and evolutionary processes (e.g.,HOXagene family andFSIP2). These results were also confirmed by GO and QTL enrichment analysis.ConclusionsOur results contribute to a better understanding of the unique adaptive genetic architecture of EAS and define its productive type, ultimately providing a new opportunity for future breeding programmes. At the same time, the numerous genes identified will improve our understanding of ruminant (sheep) robustness and resistance in the harsh and specific Mediterranean environment.
The attitude and behaviors of the different spheres of the community of the United Arab Emirates toward the clinical utility and bioethics of secondary genetic findings: a cross-sectional study
Authors: Rahma Azhar T. , Abdullahi Aminu S. , Graziano Giulia , Elbarazi Iffat 
Published: November 2023

Abstract
Introduction
Genome sequencing has utility, however, it may reveal secondary findings. While Western bioethicists have been occupied with managing secondary findings, specialists’ attention in the Arabic countries has not yet been captured. We aim to explore the attitude of the United Arab Emirates (UAE) population toward secondary findings.

Method
We conducted a cross-sectional study between July and December 2022. The validated questionnaire was administered in English. The questionnaire consists of six sections addressing topics such as demographics, reactions to hypothetical genetic test results, disclosure of mutations to family members, willingness to seek genetic testing, and attitudes toward consanguinity. Chi-squared and Fisher’s exact tests were used to investigate associations between categorical variables.

Results
We had 343 participants of which the majority were female (67%). About four-fifths (82%) were willing to know the secondary findings, whether the condition has treatment or not. The most likely action to take among the participants was to know the secondary findings, so they can make life choices (61%).

Conclusion
These results can construct the framework of the bioethics of disclosing secondary findings in the Arab regions.
Observations of Chinese fandom: organizational characteristics and the relationships inside and outside the “Fan circle”
Authors: Dan Mao , Jingya Wang , Jiajun Chen 
Published: November 2023

AbstractChinese “Fan circle” oscillate between receiving praise for their charitable endeavors and being shunned by society because of their “toxic fan culture”. This study reveals that “Fan circle “are quasi-organizational communities that heavily rely on cultural links, emotional discipline, and consent to commercial interference. While they may have some understanding of the structural benefits that social changes bring to the entertainment industry, they seem to lack the ability to comprehend the limitations imposed by national policies. Additionally, they struggle to adhere to established norms and public order when organizing internal or external interactions. “Fan circle” are advised to understand the limitations of policies, and the uniqueness and complexity of these quasi-organizational communities should also be considered in the formulation of regulatory policies.
Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study
Authors: Mazini Bianca , Dietz Matthieu , Maréchal Bénédicte , Corredor-Jerez Ricardo , Prior John O. , Dunet Vincent 
Published: November 2023

Abstract
Background
Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation between cardiac and brain SVD by using quantitative 82Rb cardiac PET/CT and brain MRI.

Results
In our population of 370 patients, 176 had normal myocardial perfusion, 38 had pure cardiac SVD and 156 had obstructive coronary artery disease. All underwent both a cardiac 82Rb PET/CT and a brain 1.5T or 3T MRI. Left-ventricle myocardial blood flow (LV-MBF) and flow reserve (LV-MFR) were recorded from 82Rb PET/CT, while Fazekas score, white matter lesion (WMab) volume, deep gray matter lesion (GMab) volume, and brain morphometry (for z-score calculation) using the MorphoBox research application were derived from MRI. Groups were compared with Kruskal–Wallis test, and the potential interrelation between heart and brain SVD markers was assessed using Pearson’s correlation coefficient. Patients with cardiac SVD had lower stress LV-MBF and MFR (P < 0.001) than patients with normal myocardial perfusion; Fazekas scores and WMab volumes were similar in those two groups (P > 0.45). In patients with cardiac SVD only, higher rest LV-MBF was associated with a lower left-putamen (rho = − 0.62, P = 0.033), right-thalamus (rho = 0.64, P = 0.026), and right-pallidum (rho = 0.60, P = 0.039) z-scores and with a higher GMab volume. Lower stress LV-MBF was associated with lower left-caudate z-score (rho = 0.69, P = 0.014), while lower LV-MFR was associated with lower left (rho = 0.75, P = 0.005)- and right (rho = 0.59, P = 0.045)-putamen z-scores, as well as higher right-thalamus GMab volume (rho = − 0.72, P = 0.009).

Conclusion
Significant interrelations between cardiac and cerebral SVD markers were found, especially regarding deep gray matter alterations, which supports the hypothesis of SVD as a systemic disease.
Evaluation of a brief virtual implementation science training program: the Penn Implementation Science Institute
Authors: Van Pelt Amelia E. , Bonafide Christopher P. , Rendle Katharine A. , Wolk Courtney , Shea Judy A. , Bettencourt Amanda , Beidas Rinad S. , Lane-Fall Meghan B. 
Published: November 2023

Abstract
Background
To meet the growing demand for implementation science expertise, building capacity is a priority. Various training opportunities have emerged to meet this need. To ensure rigor and achievement of specific implementation science competencies, it is critical to systematically evaluate training programs.

Methods
The Penn Implementation Science Institute (PennISI) offers 4 days (20 h) of virtual synchronous training on foundational and advanced topics in implementation science. Through a pre-post design, this study evaluated the sixth PennISI, delivered in 2022. Surveys measures included 43 implementation science training evaluation competencies grouped into four thematic domains (e.g., items related to implementation science study design grouped into the “design, background, and rationale” competency category), course-specific evaluation criteria, and open-ended questions to evaluate change in knowledge and suggestions for improving future institutes. Mean composite scores were created for each of the competency themes. Descriptive statistics and thematic analysis were completed.

Results
One hundred four (95.41% response rate) and 55 (50.46% response rate) participants completed the pre-survey and post-survey, respectively. Participants included a diverse cohort of individuals primarily affiliated with US-based academic institutions and self-reported as having novice or beginner-level knowledge of implementation science at baseline (81.73%). In the pre-survey, all mean composite scores for implementation science competencies were below one (i.e., beginner-level). Participants reported high value from the PennISI across standard course evaluation criteria (e.g., mean score of 3.77/4.00 for overall quality of course). Scores for all competency domains increased to a score between beginner-level and intermediate-level following training. In both the pre-survey and post-survey, competencies related to “definition, background, and rationale” had the highest mean composite score, whereas competencies related to “design and analysis” received the lowest score. Qualitative themes offered impressions of the PennISI, didactic content, PennISI structure, and suggestions for improvement. Prior experience with or knowledge of implementation science influenced many themes.

Conclusions
This evaluation highlights the strengths of an established implementation science institute, which can serve as a model for brief, virtual training programs. Findings provide insight for improving future program efforts to meet the needs of the heterogenous implementation science community (e.g., different disciplines and levels of implementation science knowledge). This study contributes to ensuring rigorous implementation science capacity building through the evaluation of programs.
Lightning Network Economics: Channels
Authors: Guasoni Paolo , Huberman Gur , Shikhelman Clara 
Published: November 2023

Compared with existing payment systems, Bitcoin’s throughput is low. Designed to address Bitcoin’s scalability challenge, the Lightning Network (LN) is a protocol allowing two parties to secure bitcoin payments and escrow holdings between them. In a lightning channel, each party commits collateral toward future payments to the counterparty and payments are cryptographically secured updates of collaterals. The network of channels increases transaction speed and reduces blockchain congestion. This paper (i) identifies conditions for two parties to optimally establish a channel, (ii) finds explicit formulas for channel costs, (iii) obtains the optimal collaterals and savings entailed, and (iv) derives the implied reduction in congestion of the blockchain. Unidirectional channels costs grow with the square-root of payment rates, while symmetric bidirectional channels with their cubic root. Asymmetric bidirectional channels are akin to unidirectional when payment rates are significantly different, otherwise to symmetric bidirectional. This paper was accepted by Joshua Gans, business strategy. Funding: Partially supported by SFI (16/IA/4443, 16/SPP/3347), Columbia-IBM Center for Blockchain and Data Transparency, Chaire Fintech at University Paris Dauphine—PSL, Algorand Foundation, and Simons Institute.
The experiences, needs and expectations of patients regarding participation at home: an explorative study in Belgium
Authors: Scheepmans Kristien , Anthierens Sibyl , De Coster Uschi , Willaert Benjamin , Paquay Louis , De Vliegher Kristel , Van Hecke Ann , Verhaeghe Sofie 
Published: November 2023

Background: Patients have an important role in the improvement of their health. Patient participation is a key component to achieving this. Some form of patient participation is already present in home care, but this needs to be optimised. Aim: Gaining insight into the expectations, experiences and needs of patients regarding patient participation in home care. Design: A qualitative design was used. Setting: The study was conducted in the Flemish part of Belgium, in a purposeful sample of patients who have already received nursing care at home for at least 6 weeks. Methods: Semi-structured face-to-face in-depth interviews were conducted and analysed using the Qualitative Analyse Guide of Leuven. Results: Patient participation in home care is a dynamic process. A total of six components, which interact with each other, were identified that explain this process. Conclusion: Patient participation in home care is the interaction of different components of a whole mechanism. Within this mechanism, home nurses play a key role to facilitate participation for patients.
Identificação e Inclusão de Alunos com Transtorno do Espectro Autista (TEA) nos Primeiros Anos Escolares: Uma Revisão da Literatura
Authors: Santos Yara da Silva , Teixeira Verônica Rejane Lima , Bringel Maricélia Felix Andrade 
Published: November 2023

O presente estudo teve por objetivo discorrer sobre o que é transtorno do espectro autista, as principais características, bem como debater a respeito de dificuldades de aprendizagens apresentadas por alguns estudantes as quais devem ser observadas atentamente pela escola e professor quando aparentar ser um autismo e a família ainda não tiver percebido, para que assim possa ser realizado uma investigação minuciosa junto a família e encaminhado a outros profissionais para que possa se chegar ao um diagnóstico correto e o professor e a escola adeque-se para atender este dentro dos seus direitos e possibilidades, proporcionando assim a inclusão. O autismo que é um transtorno do desenvolvimento que apresenta tipos variados de alterações ocorridas no sistema neurológico que resulta em dificuldades de linguagem, comunicação e interação social e diversas outras dificuldades no processo de aprendizagem escolar. Enfatizou-se a necessidade da escola frente aos casos de autismo, de buscar trabalhar com as possibilidades de melhor desenvolvimento dessas crianças, através de ações interventivas, com apoio e instruções de outros profissionais qualificados para agir com propostas adequadas e acompanhamento dessas crianças, apontando meios que minimizem suas dificuldades e venham a ter sucesso na aprendizagem. O estudo realizou-se fundamentado em autores que debatem sobre o autismo e o processo de aprendizagem escolar, tendo sido, portanto em uma revisão bibliográfica. Os resultados levaram a crer que as crianças autistas possuem capacidades diversas para construírem a sua aprendizagem, necessitando de atenção, recursos adequados e de atividades que atendam às suas particularidades, suas formas e ritmo de desenvolvimento.
Study of nanolayer on red blood cells as drug carrier in an artery with stenosis
Authors: Prasad Bhawini 
Published: November 2023

Abstract
This article discusses a novel idea from cell therapy in which nanoparticles (NPs) are adsorbed on red blood cells (RBCs). RBCs serve as a drug carrier for NPs or nanodrugs adsorbed on the cell membrane of RBC. For the purpose of examination,

Fe

3

O

4

{{\rm{Fe}}}_{3}{{\rm{O}}}_{4}

NPs are adsorbed on RBCs, collectively called NP-RBC complex. RBCs being a natural vascular carrier, have high transfusion rates and biocompatibility. This mathematical study provides a basis to attempt nanodrug delivery via RBCs, as carriers for nanodrugs, to the stenosed sites in an artery. The mathematical model is developed for an artery with stenosis and a catheter that regards the temperature and velocity of the NP-RBC complex. Catheter coated with the NP-RBC complex is inserted into the lumen of the stenosed artery. The mathematical problem is solved numerically using Bernstein polynomials. The physical features were discussed through graphs plotted using MATLAB. The influence of parameters such as volume fraction, radius of the NP-RBC complex in blood, and the thickness of the nanolayer on RBCs was studied. A noticeable outcome states that the nanolayer of optimum thickness about 50–40 nm is suitable for this purpose. Thus, this is an attempt to study the delivery of NPs adsorbed on the surface of RBCs to develop newfangled strategies in nanomedicine bearing high precision and efficiency.
Dynamical property of hyperspace on uniform space
Authors: Ji Zhanjiang 
Published: November 2023

Abstract
First, we introduce the concepts of equicontinuity, expansivity , ergodic shadowing property, and chain transitivity in uniform space. Second, we study the dynamical properties of equicontinuity, expansivity , ergodic shadowing property, and chain transitivity in the hyperspace of uniform space. Let

(

X
,
μ

)

\left(X,\mu )

be a uniform space,

(

C

(

X

)

,

C

μ

)

\left(C\left(X),{C}^{\mu })

be a hyperspace of

(

X
,
μ

)

\left(X,\mu )

, and

f
:
X
→
X

f:X\to X

be uniformly continuous. By using the relationship between original space and hyperspace, we obtain the following results: (a) the map

f

f

is equicontinous if and only if the induced map

C

f

{C}^{f}

is equicontinous; (b) if the induced map

C

f

{C}^{f}

is expansive, then the map

f

f

is expansive; (c) if the induced map

C

f

{C}^{f}

has ergodic shadowing property, then the map

f

f

has ergodic shadowing property; (d) if the induced map

C

f

{C}^{f}

is chain transitive, then the map

f

f

is chain transitive. In addition, we also study the topological conjugate invariance of

(

G
,
h

)

\left(G,h)

-shadowing property in metric

G

G

- space and prove that the map

S

S

has

(

G
,
h

)

\left(G,h)

-shadowing property if and only if the map

T

T

has

(

G
,
h

)

\left(G,h)

-shadowing property. These results generalize the conclusions of equicontinuity, expansivity, ergodic shadowing property, and chain transitivity in hyperspace.
Unpacking the positioning of being “disengaged” and “disrespectful” in class through nexus analysis: an international student’s navigation of institutional and interactional university norms
Authors: De Costa Peter , Li Wendy , Lee Jongbong 
Published: November 2023

Abstract
Given the significance of creating an inclusive academic environment for international students, our study examines how three newly arrived international students (a Chinese female and two Korean males) navigated the institutional and interactional norms in an academic orientation class at a U.S. university. Drawing on nexus analysis, we examine student class disengagement at the intersection of discourses in place, interaction order, and historical body. In particular, we focus on how the Chinese international female student was perceived as being “disengaged” and “disrespectful” in class by her Korean graduate male classmates and her female instructor. Such discursive positioning, we argue, was attributed to the interplay of various factors, such as our student participants’ navigation of U.S. classroom participation expectations. Furthermore, we argue that class disengagement should be understood within a wider sociocultural space as such disengagement is interwoven with the broader U.S. classroom discourses and individual participants’ past experiences.
Crystal structure of tricyclohexyl[4-(4H-1,2,4-triazol-4-yl)-benzoato-κO]tin(IV), C27H39N3O2Sn
Authors: Qing Jingjing , Tian Jie , Deng Xin , Zhang Fuxing 
Published: November 2023

Abstract
C27H39N3O2Sn, monoclinic, P21/c (no. 14), a = 10.3317(6) Å, b = 15.8067(9) Å, c = 16.5497(9) Å, β = 90.5380(10)°, V = 2702.6(3) Å3, Z = 4, R
gt(F) = 0.0370, wR
ref(F
2) = 0.0954, T = 296(2) K.
Breast adipose tissue‐derived extracellular vesicles from obese women alter tumor cell metabolism
Authors: Liu Shuchen , Benito‐Martin Alberto , Pelissier Vatter Fanny A , Hanif Sarah Z , Liu Catherine , Bhardwaj Priya , Sethupathy Praveen , Farghli Alaa R , Piloco Phoebe , Paik Paul , Mushannen Malik , Dong Xue , Otterburn David M , Cohen Leslie , Bareja Rohan , Krumsiek Jan , Cohen‐Gould Leona , Calto Samuel , Spector Jason A , Elemento Olivier , Lyden David C , Brown Kristy A 
Published: November 2023

AbstractBreast adipose tissue is an important contributor to the obesity–breast cancer link. Extracellular vesicles (EVs) are nanosized particles containing selective cargo, such as miRNAs, that act locally or circulate to distant sites to modulate target cell functions. Here, we find that long‐term education of breast cancer cells with EVs obtained from breast adipose tissue of women who are overweight or obese (O‐EVs) results in increased proliferation. RNA‐seq analysis of O‐EV‐educated cells demonstrates increased expression of genes involved in oxidative phosphorylation, such as ATP synthase and NADH: ubiquinone oxidoreductase. O‐EVs increase respiratory complex protein expression, mitochondrial density, and mitochondrial respiration in tumor cells. The mitochondrial complex I inhibitor metformin reverses O‐EV‐induced cell proliferation. Several miRNAs—miR‐155‐5p, miR‐10a‐3p, and miR‐30a‐3p—which promote mitochondrial respiration and proliferation, are enriched in O‐EVs relative to EVs from lean women. O‐EV‐induced proliferation and mitochondrial activity are associated with stimulation of the Akt/mTOR/P70S6K pathway, and are reversed upon silencing of P70S6K. This study reveals a new facet of the obesity‐breast cancer link with human breast adipose tissue‐derived EVs causing metabolic reprogramming of breast cancer cells.
Якість питної води та доступ до неї в Полтаві XIX — початку XX ст.
Authors: Пєшков Дмитро 
Published: November 2023

У статті проаналізовано підходи до оцінки якості питної води, які використовували в губернському місті Полтава упродовж XIX — початку ХХ століття. Простежено еволюцію методів від органолептичного (ґрунтується на суб’єктивному сприйнятті органами чуття людини) до більш наукоємних та об’єктивних – хімічного та бактеріологічного. Окрім того, досліджено різні фактори, що могли впливати на якість води в місті, насамперед антропогенний тиск (епізодичне й тимчасове зростання населення), брак екологічної свідомості, недотримання санітарних норм, обʼєктивну неможливість виконувати урядові санітарні вимоги.
Окремо розглянуто спроби удоступнити перевірену питну воду для містян. Досліджено позитивні й негативні наслідки введення в дію централізованого водогону (однак без водовідведення). Додаткову увагу звернено на відповідні політики міських інституцій, діяльність яких потребувала водозабезпечення.
У статті також висвітлено проблеми нерівного доступу до питної води для різних прошарків населення і соціальних груп, а також зв’язок якості води з епідеміями черевного тифу і холери, які поширювалися в зазначений історичний період. Проаналізовано результати протиепідемічних заходів, спрямованих на покращення водопостачання міста під час епідемій холери в 1892 та 1907–1910 рр.
Зроблено висновки, що поліпшення якості життя, зокрема завдяки водозабезпеченню, не треба розглядати як безперервний рух уперед та «еволюцію». Для українського губернського міста в ХІХ столітті антропогенні чинники, похідні від губернського статусу міста, могли мати сильніший (негативний) вплив на якість води, ніж санітарні заходи місцевої адміністрації та лікарів. Зміни у водозабезпеченні були неоднорідними для різних соціальних груп і районів міста. Ці розбіжності ще належить дослідити.