bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Data Analysis of the Use of an Autologous Multilayered Leukocyte, Platelet, and Fibrin Patch for Diabetic Foot Ulcers Treatment in Daily Clinical Practice
Authors: Mendivil Jason M. , Henderson Lorena C. , Olivas Orion S. , Deanda Mia A. , Johnson Martin L. 
Published: October 2023

ABSTRACT

OBJECTIVE
To describe the healing outcome of chronic, hard-to-heal diabetic foot ulcers (DFUs) treated with an autologous multilayered leukocyte, platelet, and fibrin (MLPF) patch in addition to the best standard of care, in a real-world clinical setting of two US amputation preventive centers.

METHODS
In this retrospective study of patients treated between September 2021 and October 2022, the authors analyzed DFU healing outcomes based on Wound, Ischemia, and foot Infection-derived amputation risk.

RESULTS
All 36 patients had a diagnosis of type 2 diabetes and 29 (81%) were male. Their average age was 61.4 years, body mass index was 29.2 kg/m2, and glycated hemoglobin was 7.9. Twenty-seven patients (78%) were diagnosed with peripheral vascular disease, 20 (56%) underwent a peripheral vascular procedure, 15 (42%) had a prior amputation, and 6 (17%) were on hemodialysis. Average wound size was 4.9 cm2, and wound age was 9.5 months. Twelve patients (32%) were classified as low risk, 15 (39%) as moderate risk, and 11 (29%) as high risk for amputation. Within 12 weeks of the first MLPF patch application, nine wounds (24%) healed. After 20 weeks, 23 wounds (61%) were closed, and by follow-up, 30 wounds (79%) healed. No amputations were noted. Compared with published data, 40% fewer patients underwent readmission within 30 days, with 72% shorter admission duration.

CONCLUSIONS
Real-world clinical experiences using the MLPF patch to treat hard-to-heal DFUs resulted in the majority of wounds healing. Few patients experienced a readmission within 30 days, and the average admission duration was short.
Driving Hospital-Acquired Pressure Injuries to Zero: A Quality Improvement Project
Authors: Aningalan Alexis M. , Gannon Brittany (Ray) 
Published: October 2023

ABSTRACT

OBJECTIVE
To implement a collaborative, interdisciplinary team approach to reducing hospital-acquired pressure injuries (HAPIs) through nurse empowerment and engagement.

METHODS
This quality improvement project was conducted at a 288-bed community hospital. The Donabedian model was used to design this intervention. The authors used a collaborative, interdisciplinary team approach for pressure injury prevention and management, utilizing nurse empowerment and engagement as driving forces to reduce HAPI rates.

RESULTS
The incidence of HAPI decreased from a peak of 5.30% in April 2019 down to 0% from August 2019 to December 2020.

CONCLUSIONS
Pressure injuries are key quality indicators for patient safety and avoidance of patient harm. Through nurse empowerment and engagement, HAPIs were avoided, resulting in improved quality care outcomes and maintenance of a safe patient environment.
Cochlear Implant Users can Effectively Combine Place and Timing Cues for Pitch Perception
Authors: Goldsworthy Raymond L. , Bissmeyer Susan R. S. 
Published: October 2023

Objectives:
The study objective was to characterize cochlear implant (CI) pitch perception for pure, complex, and modulated tones for frequencies and fundamental frequencies in the ecologically essential range between 110 and 440 Hz. Stimulus manipulations were used to examine CI users’ reliance on stimulation place and rate cues for pitch discrimination.

Design:
The study was a within-subjects design with 21 CI users completing pitch discrimination measures using pure, complex, and modulated tones. Stimulus manipulations were used to test whether CI users have better pitch discrimination for low-pass compared with high-pass filtered harmonic complexes, and to test whether they have better pitch discrimination when provided a covarying place cue when listening to amplitude-modulated tones.

Results:
Averaged across conditions, participants had better pitch discrimination for pure tones compared with either complex or amplitude-modulated tones. Participants had better pitch discrimination for low-pass compared with high-pass harmonic complexes and better pitch discrimination for amplitude-modulated tones when provided a covarying place cue.

Conclusions:
CI users integrate place and rate cues across the ecologically essential pitch range between 110 and 440 Hz. We interpret the observed better pitch discrimination for low-pass compared with high-pass filtered harmonics complexes, and for amplitude-modulated tones when provided a covarying place cue, as evidence for the importance of providing place-of-excitation cues for fundamental frequencies below 440 Hz. Discussion considers how such encoding could be implemented with existing devices.
Evaluation of Asymmetries in Speech-in Noise Abilities in Audiologic Screening for Vestibular Schwannoma
Authors: Jason Qian Z. , Vaisbuch Yona , Gianakas Steven P. , Tran Emma D. , Ali Noor-E-Seher , Blevins Nikolas H. , Fitzgerald Matthew B. 
Published: October 2023

Objectives:
Measures of speech-in-noise, such as the QuickSIN, are increasingly common tests of speech perception in audiologic practice. However, the effect of vestibular schwannoma (VS) on speech-in-noise abilities is unclear. Here, we compare the predictive ability of interaural QuickSIN asymmetry for detecting VS against other measures of audiologic asymmetry.

Methods:
A retrospective review of patients in our institution who received QuickSIN testing in addition to a regular audiologic battery between September 2015 and February 2019 was conducted. Records for patients with radiographically confirmed, unilateral, pretreatment VSs were identified. The remaining records excluding conductive pathologies were used as controls. The predictive abilities of various measures of audiologic asymmetry to detect VS were statistically compared.

Results:
Our search yielded 73 unique VS patients and 2423 controls. Receiver operating characteristic curve analysis showed that QuickSIN asymmetry was more sensitive and specific than pure-tone average asymmetry and word-recognition-in-quiet asymmetry for detecting VS. Multiple logistic regression analysis revealed that QuickSIN asymmetry was more predictive of VS (odds ratio [OR] = 1.23, 95% confidence interval [CI] [1.10, 1.38], p < 0.001) than pure-tone average asymmetry (OR = 1.04, 95% CI [1.00, 1.07], p = 0.025) and word-recognition-in-quiet asymmetry (OR = 1.03, 95% CI [0.99, 1.06], p = 0.064).

Conclusion:
Between-ear asymmetries in the QuickSIN appear to be more efficient than traditional measures of audiologic asymmetry for identifying patients with VS. These results suggest that speech-in noise testing could be integrated into clinical practice without hindering the ability to identify retrocochlear pathology.
Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance
Authors: Tian Jinbin , Bavencoffe Alexis G. , Zhu Michael X. , Walters Edgar T. 
Published: October 2023

Abstract
Nociceptor cell bodies generate “spontaneous” discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent and human dorsal root ganglia have shown that previous pain in vivo is associated with low-frequency discharge controlled by irregular depolarizing spontaneous fluctuations of membrane potential (DSFs), likely produced by transient inward currents across the somal input resistance. Using mouse nociceptors, we show that DSFs are associated with high somal input resistance over a wide range of membrane potentials, including depolarized levels where DSFs approach action potential (AP) threshold. Input resistance and both the amplitude and frequency of DSFs were increased in neurons exhibiting spontaneous activity. Ion substitution experiments indicated that the depolarizing phase of DSFs is generated by spontaneous opening of channels permeable to Na+ or Ca2+ and that Ca2+-permeable channels are especially important for larger DSFs. Partial reduction of the amplitude or frequency of DSFs by perfusion of pharmacological inhibitors indicated small but significant contributions from Nav1.7, Nav1.8, TRPV1, TRPA1, TRPM4, and N-type Ca2+ channels. Less specific blockers suggested a contribution from NALCN channels, and global knockout suggested a role for Nav1.9. The combination of high somal input resistance plus background activity of diverse ion channels permeable to Na+ or Ca2+ produces DSFs that are poised to reach AP threshold if resting membrane potential depolarizes, AP threshold decreases, or DSFs become enhanced—all of which can occur under painful neuropathic and inflammatory conditions.
Pulsed dye laser (PDL) versus photodynamic therapy (PDT) for the treatment of port wine stain (PWS): a systematic review and meta-analysis
Authors: Liu Yi-Di , Wang Ying , Zeng Jing , Li Hui , Qiu Hai-Xia , Gu Ying 
Published: October 2023

Objective:
Vascular lesions, such as port wine stain (PWS), lead to facial and psychological problems that require careful and timely treatments. This review aims to compare two mainstream methods pulsed dye laser (PDL) therapy and photodynamic therapy (PDT) for PWS.

Methods:
The Cochrane Library, PubMed, Embase, CNKI Full-Text Chinese Database and VIP Chinese Scientific Journals Database were searched for literatures comparing PDL versus PDT in treating PWS with no dates set. Studies were eligible for inclusion if they were randomised, placebo-controlled or head-to-head trials published in either English or Chinese. The primary outcome was overall response rate judged by physician/investigator-reported outcome scoring system. Adverse effects were also recorded. Review Manager (RevMan) was used to perform data synthesis. Cochrane risk of bias tool was used for methodological quality assessment. Retrospective studies were assessed based on Newcastle-Ottawa Scale.

Results:
Twelve studies met the inclusion criteria, among which eight studies had the data necessary for the meta-analysis. Among the eight studies, four were retrospective studies with 1,075 patients. The other four were RCT studies with 532 randomised participants. Regarding the overall response rate of RCT studies, PDT demonstrated no significantly higher efficacy than PDL with RR 0.76 (95% credible interval [CI] 0.48–1.20). Regarding purple types, the overall response rate of PDT was statistically significantly superior to that of PDL with RR of 0.47 (95% CI: 0.29–0.79). In terms of red types, PDT also manifested no significantly higher efficacy compared with PDL with RR of 0.85 (95% CI: 0.27–2.71).

Conclusion:
PDT is an effective and safe treatment for different types of PWS and was more effective than PDL in treating purple type of PWS.
Coronary angiography after out-of-hospital cardiac arrest without ST-segment elevation: a systematic review and meta-analysis of randomised trials
Authors: Ferraz Costa Gonçalo , Santos Iolanda , Sousa João , Beirão Sofia , Teixeira Rogério 
Published: October 2023

Background
Out-of-hospital cardiac arrest (OHCA) has a poor prognosis. The optimal timing and role of early coronary angiography (CAG) in OHCA patients without ST-segment elevation remains unclear. The goal of this study is to compare an early CAG versus delayed CAG strategy in OHCA patients without ST elevation.

Methods
We systematically searched PubMed, Embase and Cochrane databases, in June 2022, for randomised controlled trials (RCTs) comparing early versus delayed early CAG. A random effects meta-analysis was performed.

Results
A total of seven RCTs were included, providing a total of 1625 patients: 816 in an early strategy and 807 in a delayed strategy. In terms of outcomes assessed, our meta-analysis revealed a similar rate of all-cause mortality (pooled odds ratio [OR] 1.22 [0.99–1.50], P = 0.06, I2 = 0%), neurological status (pooled OR 0.94 [0.74–1.21], = 0.65, I2 = 0%), need of renal replacement therapy (pooled OR 1.11 [0.78–1.74], P = 0.47, I2 = 0%) and major bleeding events (pooled OR 1.51 [0.95–2.40], P = 0.08, I2 = 69%).

Conclusion
According to our meta-analysis, in patients who experienced OHCA without ST elevation, early CAG is not associated with reduced mortality or an improved neurological status.
Quality of life after acute kidney injury
Authors: McNicholas Bairbre , Akcan Arikan Ayse , Ostermann Marlies 
Published: October 2023

Purpose of review
Deciphering the effect of acute kidney injury (AKI) during critical illness on long-term quality of life versus the impact of conditions that brought on critical illness is difficult.

Recent findings
Reports on patient-centred outcomes such as health-related quality of life (HRQOL) have provided insight into the long-lasting impact of critical illness complicated by AKI. However, these data stem from observational studies and randomized controlled trials, which have been heterogeneous in their patient population, timing, instruments used for assessment and reporting. Recent studies have corroborated these findings including lack of effect of renal replacement therapy compared to severe AKI on outcomes and worse physical compared to cognitive dysfunction.

Summary
In adults, more deficits in physical than mental health domains are found in survivors of AKI in critical care, whereas memory deficits and learning impairments have been noted in children. Further study is needed to understand and develop interventions that preserve or enhance the quality of life for individual patients who survive AKI following critical illness, across all ages.
Blunt abdominal trauma: watch and wait
Authors: Cioffi Stefano PB. , Cimbanassi Stefania , Chiara Osvaldo 
Published: October 2023

Purpose of review
This review examines recent advancements in nonoperative management (NOM) of hemodynamically stable blunt abdominal trauma, focusing on expanding patient selection for observation-first strategies, particularly for high-grade solid organ injuries.

Recent findings
Advances include a more deliberate nonoperative approach, allowing for broader patient inclusion in diagnostic and interventional angiography. Strict clinical monitoring and appropriate follow-up strategies are crucial to identify early signs of clinical progression and complications. Repeated contrast-enhanced CT (CECT) scan can be used for close observation of high-risk injuries, while the repetition of CECTs may be avoided for lower-risk cases, such as specific high-grade kidney injuries. The role of contrast-enhanced ultrasound (CEUS) in detecting sequelae of nonoperative approaches is still debated and has lot of potential, with ongoing trials exploring possible advantages.

Summary
Multidisciplinary trauma teams play a crucial role in nonoperative management, particularly for high-grade injuries. A careful selection of patients is essential to minimize failure rates. Complications of nonoperative and angiographic approaches should be managed according to local expertise.
Digital health utilities in acute kidney injury management
Authors: Kashani Kianoush B. , Koyner Jay L. 
Published: October 2023

Purpose of review
Acute kidney injury (AKI) is a highly prevalent clinical syndrome that substantially impacts patient outcomes. It is accepted by the clinical communities that the management of AKI is time-sensitive. Unfortunately, despite growing proof of its preventability, AKI management remains suboptimal in community, acute care, and postacute care settings. Digital health solutions comprise various tools and models to improve care processes and patient outcomes in multiple medical fields. AKI development, progression, recovery, or lack thereof, offers tremendous opportunities for developing, validating, and implementing digital health solutions in multiple settings. This article will review the definitions and components of digital health, the characteristics of AKI that allow digital health solutions to be considered, and the opportunities and threats in implementing these solutions.

Recent findings
Over the past two decades, the academic output related to the use of digital health solutions in AKI has exponentially grown. While this indicates the growing interest in the topic, most topics are primarily related to clinical decision support by detecting AKI within hospitals or using artificial intelligence or machine learning technologies to predict AKI within acute care settings. However, recently, projects to assess the impact of digital health solutions in more complex scenarios, for example, managing nephrotoxins among adults of pediatric patients who already have AKI, is increasing. Depending on the type of patients, chosen digital health solution intervention, comparator groups, and selected outcomes, some of these studies showed benefits, while some did not indicate additional gain in care processes or clinical outcomes.

Summary
Careful needs assessment, selection of the correct digital health solution, and appropriate clinical validation of the benefits while avoiding additional health disparities are moral, professional, and ethical obligations for all individuals using these healthcare tools, including clinicians, data scientists, and administrators.
Education of schoolchildren in cardiopulmonary resuscitation – overview of the current literature
Authors: Schroeder Daniel C. , Finke Simon-Richard , Grübl Tobias , Jänig Christoph W. , Böttiger Bernd W. 
Published: October 2023

Purpose of review
Recognition of cardiac arrest and initiation of cardiopulmonary resuscitation (CPR) can be learned and adequately replicated by schoolchildren. Regular instruction of schoolchildren in CPR is therefore a core element to increase low bystander CPR rates. Thereby, schoolchildren CPR training evolved as own scientific field within the last decade. Aim was to describe current evidence in terms of epidemiology, teaching approaches and political aspects.

Recent findings
Schoolchildren demonstrate a high motivation to be trained in CPR. Teaching approaches that combine theoretical and practical learning sessions guarantee a sustainable learning effect. Schoolchildren can adequately perform chest compressions and mouth-to-mouth ventilation from the age of 12 years. Use of digital media is a highly promising teaching approach. CPR training conducted by teachers from the own school is effective and guarantees continuous development of CPR skills. Integration of schoolchildren CPR training into school curricula is the foundation for a sustainable increase of lay resuscitation rates in the population. Scientific and political promotion of schoolchildren CPR training is needed to sensitize the population and move bystander CPR in the social focus.

Summary
While bystander CPR rates are low in Europe comprehensive establishment of schoolchildren CPR training may sustainably increase survival after cardiac arrest.
Clinical efficacy and safety of beraprost sodium in the treatment of nephrotic syndrome: A meta-analysis
Authors: Yan Peng , Ke Ben , Fang Xiangdong 
Published: October 2023

Background:
Beraprost sodium has been shown to have positive effects in the kidney; however, its efficacy and safety in the treatment of nephrotic syndrome (NS) are currently unknown. Therefore, the aim of this meta-analysis was to evaluate the clinical efficacy and safety of beraprost sodium in the treatment of NS.

Methods:
We systematically searched EMBASE, PubMed, MEDLINE, China National Knowledge Internet (CNKI), Chinese Biomedical Database (CBM), and Wanfang database for articles from their inception to August 2022.

Results:
A total of 12 randomized controlled trials (RCTs) involving 1200 subjects were collected for careful evaluation. The meta-analysis indicated that compared with the controls, combination therapy with berprost sodium could remarkably improve the total effective rate (odds ratio 4.21, 95% confidence interval [CI]: 2.87 to 7.25) and reduce 24 hours proteinuria (mean difference [MD] −1.03, 95% CI: −1.26 to −0.8), serum creatinine (MD −18.39; 95% CI: −27.81 to −8.98), blood urea nitrogen (MD −1.43,95% CI: −1.94 to −0.92), serum total cholesterol (MD −1.24; 95% CI: −1.36 to −1.11), and triglyceride (MD −0.69; 95% CI: −1.03 to −0.35), and increase serum albumin (MD 4.96, 95% CI: 2.98 to 6.93). But the adverse effects of dizziness and headache were higher (RD = 0.05. 95% CI: 0.02 to 0.08).

Conclusion:
For NS patients, combination therapy with beraprost sodium can achieve higher clinical efficacy and significant improvement in renal function than conventional therapy.
A comprehensive approach for clustering analysis using follower-leading clustering algorithm (FLCA): Bibliometric analysis
Authors: Cheng Teng-Yun , Ho Sam Yu-Chieh , Chien Tsair-Wei , Chow Julie Chi , Chou Willy 
Published: October 2023

Background:
There are 3 issues in bibliometrics that need to be addressed: The lack of a clear definition for author collaborations in cluster analysis that takes into account collaborations with and without self-connections; The need to develop a simple yet effective clustering algorithm for use in coword analysis, and; The inadequacy of general bibliometrics in regard to comparing research achievements and identifying articles that are worth reading and recommended for readers. The study aimed to put forth a clustering algorithm for cluster analysis (called following leader clustering [FLCA], a follower-leading clustering algorithm), examine the dissimilarities in cluster outcomes when considering collaborations with and without self-connections in cluster analysis, and demonstrate the application of the clustering algorithm in bibliometrics.

Methods:
The study involved a search for articles and review articles published in JMIR Medical Informatics between 2016 and 2022, conducted using the Web of Science core collections. To identify author collaborations (ACs) and themes over the past 7 years, the study utilized the FLCA algorithm. With the 3 objectives of; Comparing the results obtained from scenarios with and without self-connections; Applying the FLCA algorithm in ACs and themes, and; Reporting the findings using traditional bibliometric approaches based on counts and citations, and all plots were created using R.

Results:
The study found a significant difference in cluster outcomes between the 2 scenarios with and without self-connections, with a 53.8% overlap (14 out of the top 20 countries in ACs). The top clusters were led by Yonsei University in South Korea, Grang Luo from the US, and model in institutes, authors, and themes over the past 7 years. The top entities with the most publications in JMIR Medical Informatics were the United States, Yonsei University in South Korea, Medical School, and Grang Luo from the US.

Conclusion:
The FLCA algorithm proposed in this study offers researchers a comprehensive approach to exploring and comprehending the complex connections among authors or keywords. The study suggests that future research on ACs with cluster analysis should employ FLCA and R visualizations.