bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of ophthalmic nurse conducted phone call follow-up of cataract surgery patients at an Australian Public Hospital
Authors: Ahmed Nauman Naveed , Wilson Tracey , White Andrew 
Published: January 2025

Background: COVID-related clinic shutdowns mandated the use of a day 1 telephone follow-up the day after routine cataract surgery rather than clinic attendance. We investigated to see if this is a safe alternative to standard care. Methods: Ninety-nine patients who underwent a routine cataract extraction between 22 April 2020 and 19 August 2020 at our Hospital were included in this audit. On post-operative day 1, a standardised questionnaire which screened for ocular symptoms and the observance of correct post-operative procedure was administered. Additionally, an ophthalmic nurse delivered a set of instructions. Patients were then reviewed at our clinic on post-operative day 30. Complications and subsequent clinical management were recorded at this consultation. Results: The complications found were largely in line with international data and included: prolonged anterior chamber inflammation, cystoid macular oedema, refractive surprise and phimosis. Management at 1-month patient review was in all cases expectant, and there were no complications requiring urgent attention. Conclusions: A nurse conducted telephone questionnaire on post-operative day 1 appears to be a safe alternative to traditional follow-up. With its implementation, ophthalmic nurses can help relieve strain on ophthalmology departments.
Identifying stakeholder perspectives and priorities for athlete monitoring technology: A mixed-methods study based on interviewing Belgian high-performance sports organisations
Authors: Aerts Jean-Marie , Moons Karen , Masci Federica , Meeusen Romain , Gielen Jasper 
Published: January 2025

The rapid growth of technology in managing training processes offers both opportunities and challenges for sports practitioners. This study examines factors influencing technology adoption in four high-performance sports: golf, sprint kayak, freestyle snowboarding, and volleyball. Each discipline reflects distinct physiological and training needs. Using an interview-based approach and including 25 stakeholders (6 athletes, 14 coaches, and 5 high-performance managers), we captured qualitative and quantitative insights into the perceived benefits and challenges of technology in athlete monitoring. The thematic analysis identified key advantages of technology in athlete monitoring, including objective data support, enhanced engagement, real-time feedback, and increased confidence, while also highlighting concerns around misuse, time demands, and technological complexity. Conflicting views on motivation, comfort, and human oversight further emphasized the challenges in integrating technology effectively. To quantify these insights, we applied the Analytic Hierarchy Process (AHP), a structured prioritisation approach that is new within sports science, to rank essential technology features. Findings ranked Reliability (1st; 18.73%) and Validity (2nd; 18.42%) as top priorities, with Interpretability (3rd; 9.95%), Responsiveness (4th; 9.02%), and Complexity (5th; 8.08%) also valued. Key training priorities included monitoring Technique (1st; 15.94%), Performance (2nd; 15.24%), and Benchmarking (3rd; 11.90%). The thematic analysis highlights the importance of balanced use of technology. In a complementary approach, the AHP provides a structured method for assessing stakeholder priorities, enhancing decision-making and helping align technology development with practitioner needs. By introducing a framework that bridges communication between engineers, scientists, and practitioners, this study guides the development of user-centred sports technologies that effectively address real-world challenges in high-performance organisations.
Outcome of acute ischemic stroke with absent opacification of the cervical internal carotid artery at CT-angiography after endovascular treatment
Authors: Comai Alessio , Casalboni Chiara , Vingiani Vincenzo , Bonatti Matteo , Franchini Enrica , Dall’Ora Elisa , Noumsi Guensom Ghislain , Lombardo Fabio , Federica Ferro , Petralia Benedetto 
Published: January 2025

Purpose: Occlusion of the distal internal carotid artery can simulate a proximal occlusion of its cervical tract on CT angiography in patients with acute ischemic stroke, that is, pseudo-occlusion. As true and false carotid occlusions can present similarly on non-invasive imaging in patients undergoing endovascular treatment for stroke, our study aimed to evaluate clinical and technical differences of these conditions and the possible consequences of a misdiagnosis. Methods: We retrospectively reviewed consecutive patients who underwent mechanical thrombectomy for acute ischemic stroke at a single center between July 2015 and May 2022 and included patients with absent opacification of the cervical carotid artery on CT-angiography. Digital subtraction angiography (DSA) imaging and procedural data were evaluated to define the actual localization of the occlusion. We compared imaging and clinical data between patients with true and false carotid occlusion, including collateral circulation at CTA, revascularization grade, and clinical outcome at 3 months. Results: A total of 116 patients were included, 63 (54%) of whom had true occlusion of cervical internal carotid artery. Compared to the pseudo-occlusion group, collateral circulation at CTA was moderate to good in 75% of cases (vs 32%; p < 0.0001) and the mean ASPECT score at 24 h was 7 versus 2 ( p < 0.0001). Modified Rankin scale 0–2 at 90 days was more frequent in patients with true occlusion than those with pseudo-occlusion (48 vs 11%; p = 0.0002). Conclusion: Pseudo-occlusion of the cervical internal carotid artery in patients with acute ischemic stroke appears to be associated with worst prognosis and poorer collateral circulation in comparison with tandem occlusion.
Genetic background and clinical phenotype in a Vietnamese cohort with Brugada syndrome: A whole exome sequencing study
Authors: Tran Viet Tuan , Pham Hung Manh , Phan Phong Dinh , Tran Thinh Huy , Tran Van Khanh 
Published: January 2025

Objectives The aim of this study was to report the spectrum of genetic variations and clinical phenotype in a Vietnamese cohort with confirmed Brugada syndrome (BrS) using the whole exome sequencing (WES). Methods Fifty patients with confirmed BrS were included in this study. Genomic DNA samples were extracted from peripheral blood and conducted for WES. The variants were annotated using ANNOVAR. The variants in the 13 reported genes associated with BrS were filtered, predicted the functional impact using eight computational tools, and classified according to the 2015 ACMG guidelines. Results Arrhythmic events were documented in one-fifth of the participants. Twenty-four probands were identified to carry 36 variants in 13 genes. Majority of the variants in our study was SCN5A variants (9/36 variants, 25%), followed by KCNH2 variants (5/36 variants, 14%). The prevalence of SCN5A carriers was 16%; while the prevalence of minor gene carriers was less than 10%. Nine novel missense variants were identified, including four missense SCN5A variants (p.E901D, p.F853L, p.L377F, and p.H184R), two missense ANK2 variants (p.S2845L and V1497L), one missense CACNA1C variant (M1126V), one missense DSP variant (p.K478N), and one intron splicing JUP variant (c.1498-5G>C). Conclusion Our study underscores the primary significance of the SCN5A gene in BrS, as indicated by variant prevalence, carrier rates, pathogenicity per ACMG classification, in silico predictions, and its correlation with clinical phenotypes. Longitudinal study with larger sample size, pedigree, Sanger sequence confirmation, and functional analysis is recommended.
Assessing the Impact of Patient-Specific Instrumentation and Fixation on Accuracy and Radiation Exposure in a Cadaveric Model of Medial Opening-Wedge High Tibial Osteotomy
Authors: Carey E. Grant , Kamath Atul F. , Vidal Armando F. , Frush Todd , Alaia Michael , Baldwin Robert B. , Ranawat Anil 
Published: January 2025

Background: Traditional freehand techniques in high tibial osteotomy (HTO) have been shown to lack precision and accuracy. Patient-specific instrumentation (PSI) and fixation created from cross-sectional imaging have recently been introduced to address this problem. Purpose/Hypothesis: The purpose of the study was to compare traditional freehand techniques versus PSI in a human cadaveric model of HTO. It was hypothesized that the osteotomies performed using PSI would require less radiation exposure for operating room staff and would reduce deviation from the planned correction in the coronal, sagittal, and axial planes. Study Design: Controlled laboratory study. Methods: Sixteen matched cadaveric knees underwent medial opening-wedge HTO via the freehand method (n = 8) or PSI technique (n = 8) with a predetermined planned opening-wedge size. Computed tomography was used to measure the achieved wedge size as well as alignment parameters in the coronal, sagittal, and axial planes. Radiation dose, number of fluoroscopic images taken, and total operative time were recorded. Results: The mean deviation from the planned wedge size was smaller in the PSI group compared with the freehand group (0.505 vs 3.016 mm, respectively; P < .01). Total radiation dose to medical staff (0.85 vs 2.04 mGy; P < .01) and number of fluoroscopic images (15.5 vs 41; P < .01) were also smaller in the PSI versus the freehand group, respectively. No difference was seen in total operative time between the 2 groups ( P = .62). Conclusion: In cadaveric specimens, the PSI technique demonstrated superior accuracy and decreased radiation exposure for medical staff compared with the traditional freehand technique without compromising operative efficiency. Clinical Relevance: The use of PSI when HTO is performed can lead to more accurate operations and potentially improve outcomes.
A Cross-sectional Study of Interrelationship Between Sleep and Sexual Dysfunction in Indian Females
Authors: Tripathi Richa , Deedwania Preeti , Koparkar Anil 
Published: January 2025

Background: Female sexual dysfunction (FSD) is a highly prevalent health problem but is often paid less attention, moreso in developing countries. There are many factors responsible for dysfunction such as disturbed sleep and mental health problems. However, it is largely understudied. Aims and objective: The aim of the present study was to observe the relationship between sleep and sexual functioning and to observe the relationship between mental health problems (depression and anxiety), sleep and sexual functioning. Method: A cross-sectional study was conducted in a tertiary health care center in India. Seventy adult female patients who were visiting Department of OBGY, OPD for any ailment, were sexually active and consenting for the study were included. The participants were evaluated on sleep, sexual activity, depression and anxiety by Pittsburgh Sleep Quality Index, Female sexual functioning index (FSFI), Beck’s depression inventory and Beck’s anxiety inventory, respectively. Result: The mean age of the sample was 33.5 (SD 6.2) years. Only 4% of the participants (n = 3) reported moderate to severe depression. Thirty percent of the participants (n = 21) reported mild anxiety symptoms. The median sleep latency of the participants was 42 (10,180) minutes. The mean subjective total sleep time was 356.6 (SD 60.3) minutes. 27.1% of the participants (n = 19) reported Global PSQI scores >5 suggesting sleep disturbance. Ten percent of the participants (n = 7) reported mild to moderate sexual dysfunction, 55.7% of the participants reported mild sexual dysfunction. A significant positive correlation was observed between hours of sleep and sexual satisfaction. Conclusion: A healthy sleep is necessary for good sexual functioning. The sexual functioning is also affected by mental health problems such as depression and anxiety in females.
Attitudes and Perspectives of Service Providers on Persons Who Use Stimulants in Northern and Central Mexico
Authors: Rafful Claudia , Jiménez-Rivagorza Leonardo , Peralta Daniela , Medina-Mora María Elena , Mota Andrés 
Published: January 2025

Background: Methamphetamine and other stimulant use are increasing across Mexico while treatment options and public funding remain scarce for substance use treatment. This study examined the attitudes and perspectives of service providers who work with persons who use stimulants in Mexico. Methods: Semistructured qualitative interviews were conducted with 20 service providers in diverse cities in the northern and central regions of Mexico, from healthcare centers and harm reduction community-based organizations (CBOs). All interviews were audio-recorded, transcribed, and de-identified. We conducted a thematic analysis to identify and compare common themes and patterns among participants, including portrayal of persons who use stimulants, dynamics of use, attitudes toward persons who use stimulants, and treatment availability and effectiveness. Results: First, service providers considered that persons who use stimulants have more complex backgrounds than others who use other substances. Second, although most providers mentioned trauma, pain, and the risk environment, CBO providers also stressed the importance of accounting for hedonism for understanding stimulant use trajectories. Third, treatment options are based on the type of services the institutions provide, usually constrained to guidelines for any substance use. In a few cases, cocaine treatment guidelines are used regardless of the type of stimulant used. Fourth, although health care services are abstinence-based, providers acknowledge the effectiveness of harm reduction approaches. In contrast, CBOs provide person-centered options. Conclusions: Overall, although service providers are aware of the increase in stimulant use, stigmatizing attitudes are prominent among some of them. However, providers in CBOs were more sensitized to their communities’ specific needs. Public policy recommendations include training to eliminate institutional stigmatization, the importance of first-person language, harm reduction effectiveness, and implementing community-based interventions to improve stimulant use-related services.
Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
Authors: Cai Maoping , Ge Shengdong , Hong Yaying , Chen Yao , Ren Yang-Zi , Zhong Dacai , Chen Mingkun , Liu Yuan , Chen Zhe-Sheng , Feng Ninghan , Chen Zhanghui , Zhao Shan-Chao 
Published: January 2025

Abstract
Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted apoptosis of PCa cells in vitro. In addition, TM suppressed the tumor growth in the cell-derived xenograft (CDX) mouse model in vivo. Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa.
Formulation of maximum weight percent gain of wood impregnated with resin considering cell wall swelling and resin concentration distribution: in the impregnation of six softwood species with phenol formaldehyde resin
Authors: Tanaka Soichi , Seki Masako , Abe Mitsuru , Miki Tsunehisa 
Published: January 2025

Abstract
Weight percent gain (WPG) is used as an index of the quantity of impregnated resin into wood. It is well‐known that the maximum value of WPG is roughly calculated using the volume of cell lumen included in wood. In this study, we proposed the theoretical formula that calculates the maximum value of WPG (W-value), with higher accuracy by considering the cell wall swelling and resin concentration distribution as well as the cell-lumen volume. In this paper, the WPG of wood for six softwood species was measured after the injection with phenol–formaldehyde resin solution and after the subsequent conditioning and drying. The measured WPG values after each process were successfully explained by the W-value calculated using the theoretical formula. It was suggested from the calculation that the WPG was greatly influenced by the cell wall swelling and by the difference in solution concentration between the cell lumen and the transient pore in the cell wall. The influences were also suggested to be larger for wood with higher density.
Knowledge translation initiatives at the Transitional Pain Service: insights from healthcare provider outreach and patient education
Authors: Lomanowska Anna M. , Tahir Rabia , Choo Christina , Zhu Sabrina , Wang Dora Y. , Slepian P. Maxwell , Katz Joel , Clarke Hance 
Published: January 2025

Abstract
Evidence-based treatment of chronic pain requires a multidisciplinary approach grounded in the biopsychosocial model. Implementing this approach within health systems relies on its acceptance by both healthcare providers and patients. While pioneering multidisciplinary pain clinics can serve as a model for implementation, a systematic effort is needed to share knowledge effectively and broadly. In the current paper we provide an overview of the knowledge translation initiatives undertaken at our Transitional Pain Service (TPS) at Toronto General Hospital, a state-of-the-art multidisciplinary pain program established in 2014 for patients at risk of developing chronic pain after surgery. The TPS team strives to enhance acceptance of this model of care among patients and providers, facilitate the establishment of similar clinics, and promote patient understanding of the integrated multidisciplinary pain care approach. Guided by the Knowledge to Action (KTA) framework, knowledge translation activities undertaken by our TPS team include clinician training, resources and outreach activities for providers, and patient education. Resource development was preceded by consultation and needs assessment among patients and providers and feedback from both groups was incorporated as part of the development process. The tailored resources were disseminated via the TPS clinic website and monitoring of online usage enables continuous evaluation of engagement. Barriers to engagement with the resources were examined through patient surveys and staff interviews. Based on these activities, we offer insights gained by our team throughout the knowledge translation process and provide recommendations for other clinical teams who wish to undertake similar initiatives.
CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis
Authors: Hou Jiwei , Ji Qijian , Tang Tianyu , Xue Yonger , Gao Lin , Dai Li , Xie Jinbing 
Published: January 2025

Abstract
Early diagnosis is critical for providing a timely window for effective therapy in pulmonary fibrosis (PF); however, achieving this remains a significant challenge. The distinct honeycombing patterns observed in computed tomography (CT) for the primary diagnosis of PF are typically only visible in patients with moderate to severe disease, often leading to missed opportunities for early intervention. In this study, we developed a nanoprobe designed to accumulate at fibroblastic foci and loaded with the CT sensitizer iodide to enable effective early diagnosis of PF. An antibody fragment (Fab′) targeting the platelet-derived growth factor receptor-α, which specifically binds to (myo)fibroblasts, was conjugated to the nanoprobe surface to enhance targeting of fibroblastic foci. Additionally, collagenase was employed to facilitate nanoprobe penetration by degrading the local collagen fibers within these foci. This approach led to significant accumulation of the CT sensitizer iodide in fibrotic lung tissues, resulting in enhanced CT imaging for the detection of fibroblastic foci and enabling early diagnosis of PF. Moreover, a dual-drug combination of oltipraz and rosiglitazone was co-loaded into the nanoparticles for the treatment of early-diagnosed PF. Remarkable therapeutic efficacy was observed in model mice with early PF using these nanoparticles. Our findings present a promising strategy for the early diagnosis of PF, potentially offering a valuable time window for effective treatment of this life-threatening disease.
Ulinastatin treatment mitigates glycocalyx degradation and associated with lower postoperative delirium risk in patients undergoing cardiac surgery: a multicentre observational study
Authors: Ran Xiao , Xu Tingting , Liu Jieqiong , Yang Shaobing , Luo Fang , Wu Rongxue , Tan Juan , Ruan Hang , Zhang Qin 
Published: January 2025

Abstract

Background
Ulinastatin (UTI), recognized for its anti-inflammatory properties, holds promise for patients undergoing cardiac surgery. This study aimed to investigate the relationship between intraoperative UTI administration and the incidence of delirium following cardiac surgery.

Methods
A retrospective analysis was performed on a retrospective cohort of 6,522 adult cardiac surgery patients to evaluate the relationship between UTI treatment and the incident of postoperative delirium (POD) in patients ongoing cardiac surgery. This was followed by a prospective observational cohort study of 241 patients and an in vitro study to explore the findings and the potential role of UTI in preventing cardiac ischemia–reperfusion induced glycocalyx degradation.

Results
Both univariate and multivariate logistic regression analyses in retrospective cohort indicated that intraoperative administration of UTI was associated with a significant lower risk of POD among cardiac surgery patients, a finding confirmed through employing propensity score matching. The subsequent prospective observational cohort further supported these findings (adjusted Odds Ratio = 0.392, 95% CI: 0.157–0.977, P = 0.044). Furthermore, UTI mitigated glycocalyx degradation, as demonstrated by in vitro study.

Conclusions
UTI administration may mitigate glycocalyx degradation, potentially lowering the risk of POD in cardiac surgery patients, offering valuable insights for future interventions to prevent POD and enhance patient outcomes.

Trial registration number ClinicalTrials.gov (No. NCT06268249). Retrospectively registered 4 February 2024.