bluuebunny/crossref_metadata_2025_split huggingface dataset:
In situ flow state characterization of molten resin at the inner mold in injection molding
Authors: Zhao Nanyang , Liu Junfeng , Bi Mingcheng , Xu Zhongbin , Zhou Jing , Ding Jisong , Wu Qiong 
Published: December 2023

AbstractOnline viscosity information on processing lines can reflect the material flow resistance and offer valuable guidance for manufacturing across various industries. Considering the accuracy, devices, and processes involved in injection molding, characterizing the melt's flow state during material processing poses a significant challenge. To reduce investment in viscometers, avoid influencing the components' surface aesthetics due to the installation of sensors, and make the flow state detect online in mold, this study designs a rheometric mold with cylindrical runners for identifying the in situ viscosity of molten resin during injection molding. The detection conditions of injection speed and cavity pressure variations, the entrance effect, and the viscous dissipation for Polycarbonate are analyzed under various conditions. The in situ viscosity is identified and compared with the standard cross‐WLF model. The result shows that the melt velocity and cavity pressure variations during the filling process create a stable environment for in situ rheological characterization and the detected viscosity is related to the shear rate, melt temperature, and channel dimension in injection molding. The designed mold with cylindrical runners for determining the in situ thermal‐rheological behavior of polymer is distinguished successfully and exhibits prospects for the development of low‐cost, nondestructive, and inner‐mold measurement in manufacturing applications.
Physical frailty deteriorates after a 5‐day dexamethasone course in children with acute lymphoblastic leukemia, results of a national prospective study
Authors: Verwaaijen Emma J. , van Hulst Annelienke M. , Hartman Annelies , Pieters Rob , Fiocco Marta , Pluijm Saskia M. F. , van Litsenburg Raphaële R. L. , Grootenhuis Martha A. , van den Akker Erica L. T. , van den Heuvel‐Eibrink Marry M. 
Published: December 2023

AbstractBackgroundDexamethasone is important in the treatment for pediatric acute lymphoblastic leukemia (ALL) but induces muscle atrophy with negative consequences for muscle mass, muscle strength, and functional abilities. The aim of this study was to establish the effect of a dexamethasone course on sarcopenia and physical frailty in children with ALL, and to explore prognostic factors.MethodsPatients with ALL aged 3–18 years were included during maintenance therapy. Patients had a sarcopenia/frailty assessment on the first day of (T1) and on the day after (T2) a 5‐day dexamethasone course. Sarcopenia was defined as low muscle strength in combination with low muscle mass. Prefrailty and frailty were defined as having two or ≥three of the following components, respectively: low muscle mass, low muscle strength, fatigue, slow walking speed, and low physical activity. Chi‐squared and paired t‐tests were used to assess differences between T1 and T2. Logistic regression models were estimated to explore patient‐ and therapy‐related prognostic factors for frailty on T2.ResultsWe included 105 patients, 61% were boys. Median age was 5.3 years (range: 3–18.8). At T1, sarcopenia, prefrailty, and frailty were observed in respectively 2.8%, 23.5%, and 4.2% of patients. At T2, the amount of patients with frailty had increased to 17.7% (p = 0.002), whereas the number of patients with sarcopenia and prefrailty remained similar. Higher ASMM (odds ratio [OR]: 0.49, 95% CI: 0.28–0.83), stronger handgrip strength (OR: 0.41, 95% CI: 0.22–0.77) and more physical activity minutes per day (OR: 0.98, 95% CI: 0.96–0.99) decreased the risk of frailty at T2. Slower walking performance (OR: 2, 95% CI: 1.2–3.39) increased the risk. Fatigue levels at T1 were not associated with frailty at T2.ConclusionPhysical frailty increased strikingly after a 5‐days dexamethasone course in children with ALL. Children with poor physical state at start of the dexamethasone course were more likely to be frail after the course.
‘Like I'd been listened to without actually saying words’: Picturing the nurturer in compassion‐focused therapy
Authors: Crone Rachel Louise , Brown Richard James , Bell Tobyn 
Published: December 2023

AbstractObjectiveA core component of compassion‐focussed therapy (CFT) is imagery. This study aimed to explore the experiences of ‘compassionate other’ imagery practice in individuals with social anxiety.MethodEight individuals were interviewed about their experiences of the imagery practice as part of CFT in NHS primary care services, and interpretative phenomenological analysis was used to analyse the data.ResultsThree group experiential themes were identified as follows: uncovering obstacles and resistances, revealing compassionate other qualities and imagery as a vehicle to self‐discovery.ConclusionsThe results highlighted not only the challenges in developing and utilising an imaginal caring figure but also the benefits of self‐discovery, specifically in terms of identifying unmet emotional needs. Links between the themes and processes underpinning the results are explored in relation to the existing theories and literature. Clinical implications and suggestions for further research are also discussed.
Preemptive inotuzumab ozogamicin eradicated measurable residual disease in Ph‐negative acute lymphoblastic leukemia relapsed post CD19 CART therapy
Authors: Huang Si‐Man , Wan Chao‐Ling , Cao Han‐Yu , Li Yan‐Yan , Qian Chong‐Sheng , Zhou Hai‐Xia , Xu Ming‐Zhu , Hu Xiao‐Hui , Dai Lan , Dai Hai‐Ping , Xue Sheng‐Li 
Published: December 2023

Key Clinical MessageThere are no reports of application of inotuzumab ozogamicin (InO) for the treatment of MRD in r/r B‐ALL. We firstly report the efficacy of InO for a patient experienced morphological relapse after HSCT and molecular relapse after CART therapy.
Bilateral endogenous Candida albicans endophthalmitis following COVID‐19 infection and intravenous antibiotics use: A case report
Authors: Wu Shuang , Wang Cunbo , Zhang Yanbing 
Published: December 2023

Key Clinical MessageEndogenous fungal endophthalmitis tends to occur in immunocompromised patients, including COVID‐19 infection. For high‐risk populations, timely tissue biopsy, fungal culture, and susceptibility testing can facilitate early diagnosis and treatment, thereby improving the prognosis.AbstractWhile endogenous fungal endophthalmitis is a rare condition, its incidence has recently been on the rise. A 48‐year‐old male presented with complaints of acute visual loss in his right eye for 2 weeks. He had a history of COVID‐19 infection, confirmed by a positive nucleic acid test, and was treated with intravenous antibiotics and glucocorticoids a week before the episode. A comprehensive eye examination revealed significant inflammatory cells floating in the anterior chamber and considerable cloudiness in the vitreous of the right eye, while few vitreous cells were visualized in the left eye. After pars plana vitrectomy (PPV) was performed in the right eye, a vitreous biopsy revealed an intravitreal infection of Candida albicans, which was susceptible to fluconazole. Endogenous fungal endophthalmitis occurs in patients with various underlying systemic conditions, such as those with diabetes, organ transplantation recipients, individuals undergoing chemotherapy, users of corticosteroids and immunosuppressants, AIDS patients, and those engaged in intravenous drug use. In high‐risk populations associated with intravenous antibiotics, the timely identification of one or more well‐defined oval yellow‐white chorioretinal lesions, especially in the posterior pole of the retina, can contribute to an early diagnosis through tissue biopsy, fungal culture, and susceptibility testing. This approach enables targeted antifungal therapy, thereby improving the prognosis of visual function for the patient.
Unexpected coccidioidomycosis presenting as lung nodules with presumptive diagnosis of malignancy
Authors: Cai Jennifer , Sin David , Tomassetti Sarah 
Published: December 2023

Key clinical messageCoccidioidomycosis can present as fluorodeoxyglucose (FDG) avid lung nodules which may be mistaken as relapse in patients with a history of malignancy. Detailed clinical history, relevant laboratory testing, and/or tissue biopsy with histologic evaluation are necessary for correct diagnosis.
Fluorescence color change of supramolecular polymer networks controlled by crown ether‐cation recognition
Authors: Han Weiwei , Tian Hailan , Qiang Taotao , Wang Hu , Wang Pi 
Published: December 2023

AbstractWe report a fluorescent supramolecular polymer networks (SPNs) system based on crown ether‐cation recognition. The polymer side chains bear ammonium cations, which can be recognized by host molecules with a B15C5 unit and a quinoline group at each end. The quinoline group makes the host molecule exhibit blue fluorescence. After the formation of SPNs, the recognition of the crown ether‐cation transforms the blue fluorescence into yellow fluorescence. The accompanying fluorescence color change during the formation of SPNs makes it with potential applications in the fields of display, printing, information storage, and bioimaging.
Molecular Nanoarchitectonics of Natural Photosensitizers and Their Derivatives Nanostructures for Improved Photodynamic Therapy
Authors: Li Xiaochen , Liu Yilin , Wu Lili , Zhao Jie 
Published: December 2023

AbstractNatural photosensitizers (PSs) and their derivatives have drawn ever‐increasing attention in photodynamic therapy (PDT) for their wild range of sources, desirable biocompatibility, and good photosensitivity. Nevertheless, many factors such as poor solubility, high body clearance rate, limited tumor targeting ability, and short excitation wavelengths severely hinder their applications in efficient PDT. In recent years, fabricating nanostructures by utilizing molecular assembly technique is proposed to solve these problems. This technique is easy to put into effect, and the assembled nanostructures could improve the physical properties of the PSs so as to meet the requirement of PDT. In this concept, we focus on the construction of natural PSs and their derivatives nanostructures through molecular assembly technique to enhance PDT efficacy (Figure 1). Furthermore, current challenges and future perspectives of natural PSs and their derivatives for efficient PDT are discussed.
Immunotherapy: Advancing glioblastoma treatment—A narrative review of scientific studies
Authors: Tiwari Sagun , Han Zhenxiang 
Published: December 2023

AbstractBackgroundGlioblastoma (GB) is an aggressive and deadly brain tumor with a poor prognosis despite the current standard of care, including surgery, radiation, and chemotherapy.Recent FindingsIn recent years, there has been increasing interest in the potential of immunotherapies, seen to be effective in treating other cancers, in the treatment of GB. This comprehensive review presents an in‐depth analysis of the remarkable progress of immunotherapy in GB treatment, focusing on human clinical studies. It also analyzes the current findings, challenges, and limitations that underscore the transformative potential of immunotherapy in managing GB. Of particular significance, it delves into the intriguing interaction of the human microbiome with immunotherapy as a novel avenue for enhancing treatment outcomes of GB.ConclusionThis study sheds light on the complex GB therapy landscape and the cutting‐edge strategies that show promise for enhancing patient prognosis.
Building a metric of color reproduction difference by combining multiple observers in a modular online experiment
Authors: High Gregory , Nussbaum Peter , Green Phil 
Published: December 2023

AbstractA web‐hosted online experiment was previously developed to find the visual difference between four reproduction gamuts using direct magnitude estimation (Proc. IS&T 29th Color and Imaging Conf, 2021:317–322). In order to increase the size of the data set, but without overburdening observers, a modular approach was adopted. The original methodology was therefore extended across 10 linked sub‐experiments to make comparisons between some 36 gamuts, which were designed to exhibit a variety of different gamut shapes, contrast ratios, and substrate colors within the constraints of a desktop display. In addition to each set of test images, a common normalization set was included in all sub‐experiments in order to adjust each observer's choice of modulus to a global average observer, and thus combine the results into a larger data set. Finally, an interval scale was inferred from the normalized magnitude data using a categorical judgment approach to calculate scale values. The fitted data revealed a power function close to a square‐root between the interval and magnitude scales.
Comparative physiological and transcriptomic analysis of two contrasting soybean genotypes reveals complex mechanisms involved in drought avoidance
Authors: Li Shengyou , Yan Chunjuan , Cao Yongqiang , Wang Changling , Sun Xugang , Zhang Lijun , Wang Wenbin , Song Shuhong 
Published: December 2023

AbstractTo overcome drought stress in soybean (Glycine max), it is strategically vital to improve drought resistance. Yet, the underlying molecular mechanisms responsible for drought resistance remain poorly defined. Here, we present comparative physiological and transcriptome analyses in seedlings of two contrasting genotypes, drought‐resistant (DR) L14 and drought‐sensitive (DS) L21 in response to polyethylene glycol (PEG)‐induced drought stress. Each genotype was subjected to 20% PEG along with control (0% PEG) in a greenhouse, and the leave samples were collected to determine the physiological traits and transcriptome profiling. With the accumulation of abscisic acid (ABA) under drought stress, the DR genotype exhibited higher water retention capability and slow‐wilting phenotype compared to DS genotype. As nonsignificant changes in oxidative damages and antioxidant defenses, overcoming drought stress in DR genotype was facilitated by drought avoidance rather than drought tolerance. There were 1567 and 4029 differentially expressed genes (DEGs) identified in the DR and DS genotypes, respectively. The DEGs were mostly enriched in photosynthesis, carbohydrate metabolism, lipid metabolism, cell wall organization, and signaling pathways, which were less affected in DR genotype. However, most of the leucine‐rich repeat receptor‐like kinases (LRR‐RLKs) were uniquely downregulated in DS genotype but uniquely upregulated in DR genotype by drought stress. By protein–protein interaction network analysis and whole genome resequencing, six LRR‐RLKs were considered the potential candidate genes for drought avoidance. We suggested that these LRR‐RLKs may play a critical role in promoting ABA‐induced stomatal closure through enhancing ABA sensitivity, but this hypothesis needs further validation. Taken together, these findings could provide in‐depth insights into the physiological and molecular mechanisms associated with drought avoidance and facilitate the breeding of drought‐resistant soybean cultivars.
Development of a strategy deployment framework combining corporate sustainability and operational excellence
Authors: Roche Katharina E. , Baumgartner Rupert J. 
Published: December 2023

AbstractOperations management requires models, methods and tools that integrate both sustainability and operational excellence to support organizations in implementing long‐term sustainability. The purpose of this research is to provide a strategy deployment framework integrating both corporate sustainability and operational excellence. The research approach includes an explorative literature review, providing a background on operational excellence, sustainability, and hoshin kanri, a special form of strategy deployment. Comprehensive frameworks for both strategy deployment (hoshin kanri) and sustainability (Framework for Strategic Sustainable Development) were used as a foundation and adapted towards a strategy deployment framework linking sustainability with operational excellence. This was done by integrating both frameworks and by including operational excellence enablers. The resulting framework illustrates how strategic sustainability goals can be aligned and deployed within businesses. This research contributes towards supporting corporations in their efforts in becoming sustainable businesses and serves as a theoretical base for future research.
Charcot neuroarthropathy in persons with diabetes: It's time for a paradigm shift in our thinking
Authors: Wukich Dane K. , Frykberg Robert G. , Kavarthapu Venu 
Published: December 2023

AbstractThe aim of this paper is to review the recent literature regarding the epidemiology and surgical management of Charcot neuro‐osteoarthropathy (CNO). We propose that a fundamental change in the approach and assumptions regarding the historical treatment of active CNO should be considered. Although the true incidence and prevalence of CNO in the US population with diabetes are not known, we estimated the incidence to be 27,602 per year and the prevalence to be 208,880 persons. In persons with diabetes, the incidence of CNO is higher than that of prostate, lung, kidney, and thyroid cancer, and in the entire US population, the incidence of CNO is higher than that of multiple myeloma, soft tissue sarcoma, and primary bone sarcoma. In persons with diabetes, the incidence of CNO is higher than fractures of the femoral shaft, distal femur, tibia, talus, calcaneus and Lisfranc ligament injuries. Surgical techniques have evolved over the past half century, and surgery is the standard for treating displaced fractures and intra‐articular injuries. Since CNO is a fracture, dislocation, or fracture dislocation in patients with neuropathy, why do we treat CNO differently? Elsewhere in the skeleton displaced osseous and ligament injuries are treated surgically. Based on the information presented in this manuscript, we suggest that it is time for a paradigm shift in the treatment of persons with CNO. While uncommon, CNO in persons with diabetes is not rare. Given the advances in surgical techniques, surgical intervention should be considered earlier in persons with CNO who are at risk for developing deformity related foot ulceration.
Longitudinal cardiovascular health measured by life's essential 8 metrics with incident diabetes: A 13‐year prospective cohort study
Authors: Tian Xue , Chen Shuohua , Xu Qin , Xia Xue , Zhang Yijun , Zhang Xiaoli , Wang Penglian , Wu Shouling , Wang Anxin 
Published: December 2023

AbstractAimsTo investigate the associations of baseline and longitudinal cardiovascular health (CVH) measured by ‘Life's Essential 8’ (LE8) metrics with the risk of diabetes in Chinese people with normoglycaemia or prediabetes.Materials and MethodsA total 86,149 participants without diabetes were enroled from the Kailuan study and were stratified by baseline glycaemic status (normoglycaemia or prediabetes). Cardiovascular health score ranged from 0 to 100 points was categorised into low (0–49), middle (50–79), and high (80–100) CVH status. Cox regressions were used to assess the associations of baseline and time‐updated CVH status with incident diabetes in the overall cohort and across baseline glycaemic statuses.ResultsDuring a median follow‐up of 12.94 (interquartile rage: 12.48–13.16) years, we identified 13,097 (15.20%) cases of incident diabetes. Baseline and time‐updated high CVH status was associated with a lower risk of diabetes, the corresponding hazard ratio (HR) versus low CVH status was 0.27 (95% confidence interval [CI], 0.23–0.31) and 0.26 (95% CI, 0.23–0.30) in the overall cohort, respectively. Additionally, the effect of high CVH on diabetes was more prominent in participants with normoglycaemia than those with prediabetes (P < 0.0001), with an HR of 0.26 (95% CI, 0.22–0.31) versus 0.50 (95% CI, 0.41–0.62) for baseline CVH, and 0.25 (95% CI, 0.21–0.30) versus 0.39 (95% CI, 0.32–0.48) for time‐updated CVH.ConclusionsElevated baseline and longitudinal CVH score assessed by LE8 metrics is associated with a lower risk of subsequent diabetes, especially in normoglycaemic adults.
Nonmuscular Troponin‐I is required for gastrulation in sea urchin embryos
Authors: Kamata Mai , Taniguchi Yuri , Yaguchi Junko , Tanaka Hiroyuki , Yaguchi Shunsuke 
Published: December 2023

AbstractBackgroundGastrulation is one of the most important events in our lives (Barresi and Gilbert, 2020, Developmental Biology, 12th ed.). The molecular mechanisms of gastrulation in multicellular organisms are not yet fully understood, since many molecular, physical, and chemical factors are involved in the event.ResultsHere, we found that one of muscle components, Troponin‐I (TnI), is expressed in future gut cells, which are not muscular cells at all, and regulates gastrulation in embryos of a sea urchin, Hemicentrotus pulcherrimus. When we block the function of TnI, the invagination was inhibited in spite that the gut‐cell specifier gene is normally expressed. In addition, blocking myosin activity also induced incomplete gastrulation.ConclusionThese results strongly suggested that TnI regulates nonmuscular actin–myosin interactions during sea urchin gastrulation. So far, Troponin system is treated as specific only for muscle components, especially for striated muscle, but our data clearly show that TnI is involved in nonmuscular event. It is also reported that recent sensitive gene expression analysis revealed that Troponin genes are expressed in nonmuscular tissues in mammals (Ono et al., Sci Data, 2017;4:170105). These evidences propose the new evolutionary and functional scenario of the involvement of Troponin system in nonmuscular cell behaviors using actin‐myosin system in bilaterians including human being.
Generation of tamoxifen‐inducible Tfap2b‐CreERT2 mice using CRISPR‐Cas9
Authors: Zhang Mingyi , Feng Jifan , Li Yue , Qin Peter Z. , Chai Yang 
Published: December 2023

SummaryTfap2b, a pivotal transcription factor, plays critical roles within neural crest cells and their derived lineage. To unravel the intricate lineage dynamics and contribution of these Tfap2b+ cells during craniofacial development, we established a Tfap2b‐CreERT2 knock‐in transgenic mouse line using the CRISPR‐Cas9‐mediated homologous direct repair. By breeding with tdTomato reporter mice and initiating Cre activity through tamoxifen induction at distinct developmental time points, we show the Tfap2b lineage within the key neural crest‐derived domains, such as the facial mesenchyme, midbrain, cerebellum, spinal cord, and limbs. Notably, the migratory neurons stemming from the dorsal root ganglia are visible subsequent to Cre activity initiated at E8.5. Intriguingly, Tfap2b+ cells, serving as the progenitors for limb development, show activity predominantly commencing at E10.5. Across the mouse craniofacial landscape, Tfap2b exhibits a widespread presence throughout the facial organs. Here we validate its role as a marker of progenitors in tooth development and have confirmed that this process initiates from E12.5. Our study not only validates the Tfap2b‐CreERT2 transgenic line, but also provides a powerful tool for lineage tracing and genetic targeting of Tfap2b‐expressing cells and their progenitor in a temporally and spatially regulated manner during the intricate process of development and organogenesis.