bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a predictive nomogram for breast cancer lympho-vascular invasion based on radiomics obtained from digital breast tomography and clinical imaging features
Authors: liang Gang , Zhang Suxin , Zheng Yiquan , Chen Wenqing , Liang Yuan , Dong Yumeng , Lizhen L I , Li Jianding , Yang Caixian , Jiang Zengyu , He Sheng 
Published: February 2024

Abstract
Background
To develop a predictive nomogram for breast cancer lympho-vascular invasion (LVI), based on digital breast tomography (DBT) data obtained from intra- and peri-tumoral regions.
Methods
192 breast cancer patients were enrolled in this retrospective study from 2 institutions, in which Institution 1 served as the basis for training (n = 113) and testing (n = 49) sets, while Institution 2 served as the external validation set (n = 30). Tumor regions of interest (ROI) were manually-delineated on DBT images, in which peri-tumoral ROI was defined as 1 mm around intra-tumoral ROI. Radiomics features were extracted, and logistic regression was used to construct intra-, peri-, and intra-+peri-tumoral “omics” models. Patient clinical data was analyzed by both uni- and multi-variable logistic regression analyses to identify independent risk factors for the clinical imaging model, and the combination of both the most optimal “omics” and clinical imaging models comprised the comprehensive model. The best-performing model out of the 3 types (“omics”, clinical imaging, comprehensive) was identified using receiver operating characteristic (ROC) curve analysis, and used to construct the predictive nomogram.
Results
The most optimal “omics” was the intra-+peri-tumoral model, and 3 independent risk factors for LVI, maximum tumor diameter (odds ratio [OR] = 1.486, 95% confidence interval [CI] = 1.082–2.041, P = 0.014), suspicious malignant calcifications (OR = 2.898, 95% CI = 1.232–6.815, P = 0.015), and axillary lymph node (ALN) metastasis (OR = 3.615, 95% CI = 1.642–7.962, P < 0.001) were identified by the clinical imaging model. Furthermore, the comprehensive model was the most accurate in predicting LVI occurrence, with areas under the curve (AUCs) of 0.889, 0.916, and 0.862, for, respectively, the training, testing and external validation sets, compared to “omics” (0.858, 0.849, 0.844) and clinical imaging (0.743, 0.759, 0.732). The resulting nomogram, incorporating radiomics from the intra-+peri-tumoral model, as well as maximum tumor diameter, suspicious malignant calcifications, and ALN metastasis, had great correspondence with actual LVI diagnoses under the calibration curve, and was of high clinical utility under decision curve analysis.
Conclusion
The predictive nomogram, derived from both radiomics and clinical imaging features, was highly accurate in identifying future LVI occurrence in breast cancer, demonstrating its potential as an assistive tool for clinicians to devise individualized treatment regimes.
Co-seismic and rainfall triggered landslide hazard susceptibility framework for Uganda derived using fuzzy logic and geospatial modelling techniques
Authors: Oleng Morris , Ozdemir Zuhal , Pilakoutas Kypros 
Published: February 2024

Abstract
Over the past few decades, Uganda has suffered from many damaging landslides like the 2010 Bududa, 1994 Kisomoro and 1966 Rwenzori events. Although most slope failures are rainfall-induced, earthquakes can also trigger larger scale landslides. Despite escalating landslide risk exacerbated by rapid population growth and urbanization coupled with a substandard building stock, comprehensive national co-seismic and rainfall-induced landslide hazard and risk maps for Uganda do not exist. This study aims to develop a co-seismic landslide hazard susceptibility framework using a geospatial-based fuzzy logic methodology. Initially landslide conditioning factor maps are created, aggregated with a stochastic event-based probabilistic seismic hazard model developed using OpenQuake-engine, and their spatial distribution is overlaid to produce final fuzzy sets describing relative probabilities of co-seismic landslide hazard. Seismic hazard map for a 475-year return period shows maximum bedrock peak ground acceleration increasing to 0.27 g in western Uganda. Further results show that areas of Precambrian granites located in upper slopes with gradients between 35 and 40o have the highest landslide frequency ratios. Whilst the majority of the country is exposed to relatively low hazard, the Rwenzori and Kigezi regions are highly susceptible to co-seismic landslides. To reduce the earthquake and landslide risks across Uganda, it is recommended that the directorate of disaster preparedness and management should develop suitable disaster risk mitigation measures like: local planning and zoning, structural retrofitting and infrastructure protection for key public buildings, natural system protection, and education towards raising community awareness.
Biliary Endoscopic Drainage of Septic ICU Patients Deemed Emergent (BEDSIDE)
Authors: Chittajallu Vibhu , Elangovan Abbinaya , Omar Yazan Abu , Satyavada Sagarika , Hayat Umar , Vozzo Catherine , Wong Richard C. , Dumot John A. , Glessing Brooke , Isenberg Gerard A. , Faulx Ashley L. , Chak Amitabh 
Published: February 2024

Abstract
Background
Mortality for severe acute cholangitis is significantly reduced after endoscopic biliary drainage. Our institution has utilized ERCP without fluoroscopy in the intensive care unit (ICU), termed Biliary Endoscopic Drainage of Septic ICU patients Deemed Emergent (BEDSIDE) ERCP, in rare circumstances for critically ill patients with severe acute cholangitis where timely conventional ERCP was not available and delayed biliary drainage could adversely affect clinical outcomes. The objective of this study is to describe the BEDSIDE technique and its feasibility to provide expedited biliary drainage in critically ill patients in the ICU with severe acute cholangitis where timely conventional ERCP was not available.
Methods
We performed a retrospective cohort study from 2012–2022 at our tertiary care hospital system of patients who underwent BEDSIDE ERCP for acute cholangitis. Data collection included demographics, hospital course, and endoscopic findings.
Results
We identified 14 patients who underwent BEDSIDE ERCPs. Identified patients were critically ill with high incidences of vasopressor requirements (79%), mechanical ventilation (43%), and SIRS (100%). Median time from admission to ERCP was 13.6 hrs (range 9.3–18.5 hrs). BEDSIDE approach had successful biliary stent placement in 11 patients (79%), including all 5 patients with prior biliary sphincterotomies. 30-day cholangitis-related mortality was 14%.
Conclusion
BEDSIDE ERCP is proposed as a feasible approach to expedited biliary drainage for critically ill patients in the ICU with severe acute cholangitis in the rare circumstances that timely conventional ERCP with fluoroscopy is unavailable and further delayed biliary drainage could negatively affect clinical outcomes.
Chlamydia psittaci detected at a live poultry wholesale market in central China
Authors: Zhang Rusheng , Fu Huiyuan , Luo Can , Huang Zheng , Pei Ruiqing , Di Yu , Zhu Caiying , Peng Jiayi , Hu Huiqi , Chen Shan , Chen Jingfang , Chen Lamei , Xu Mingzhong , Yang Xuewen , Yang Rengui 
Published: February 2024

Abstract

Background
We investigated the presence of Chlamydia psittaci in poultry and the environment in live poultry wholesale markets in Changsha during 2021–2022 and conducted phylogenetic analysis to understand its distribution in this market.
Methods
In total, 483 samples were analyzed using real-time polymerase chain reaction and 17 C. psittaci-positive samples using high-throughput sequencing, BLAST similarity, and phylogenetic analysis.
Results
Twenty two out of 483 poultry and environmental samples were positive for C. psittaci (overall positivity rate: 4.55%) with no difference in positivity rates over 12 months. Chlamydia psittaci was detected at 11 sampling points (overall positivity rate: 27.5%), including chicken, duck, and pigeon/chicken/duck/goose shops, with pigeon shops having the highest positivity rate (46.67%). The highest positivity rates were found in sewage (12.5%), poultry fecal (7.43%), cage swab (6.59%), avian pharyngeal/anorectal swab (3.33%), and air (2.29%) samples. The ompA sequences were identified in two strains of C. psittaci, which were determined to bear genotype B using phylogenetic analysis. Thus, C. psittaci genotype B was detected in the poultry and environmental samples from the poultry wholesale market in Changsha during monitoring.
Conclusions
Monitoring programs for C. psittaci in live markets need to be strengthened to address the possible zoonotic threat.
Techno-Economic Assessment of Biohydrogen Production from Dark Fermentation of Wastewater Sludge
Authors: Alam Monisha , Nayan Nusrat Fatema 
Published: February 2024

Abstract
This paper explores a simulation model for biohydrogen production by dark fermentation of wastewater sludge using the Aspen Plus process simulation software. The process includes sludge pretreatment, hydrolysis, fermentation and post-treatment of the products though separation and purification. The outcomes of the model serve as inputs for a techno-economic analysis to assess the economic viability of the process. Additionally, a sensitivity analysis is employed to scrutinize the influence of crucial variables on the overall process. Finally, a greenhouse gas emission potential of the proposed system was obtained from literature, to ensure the environmental benefits from this process. The cost analysis for 23 ton/day sludge processing capacity dark fermentation plant showed a biohydrogen production cost of $11.4/kg of hydrogen produce. The capital cost and the labor cost have been the key contributors to the production cost. The biohydrogen price decreased to $5.9/ kg when the plant was scaled up to 500 ton/day capacity. Examining the greenhouse gas (GHG) emission potential of the process from literature unveiled a substantial reduction in GHG emissions and a carbon credit of $90/ ton CO2-eq can lower the biohydrogen production price to $1.28/kg, rendering it competitive to hydrogen price produced from natural gas-based technology.
Biomarkers of Biological Age: Metabolomic Insights from the TMM Cohort Project
Authors: Sakurai Miyuki , Motoike Ikuko N. , Hishinuma Eiji , Aoki Yuichi , Tadaka Shu , Kogure Mana , Orui Masatsugu , Ishikuro Mami , Obara Taku , Nakaya Naoki , Kumada Kazuki , Hozawa Atsushi , Kuriyama Shinichi , Yamamoto Masayuki , Koshiba Seizo , Kinoshita Kengo 
Published: February 2024

Abstract
Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
Authors: Li Chunyan , Ajmal Erum , Khaled Alok , Powell Keren , Wadolowski Steven , Turpin Justin , Barthélemy Ernest , LeDoux David 
Published: February 2024

Abstract
Background
The outcomes of traumatic brain injury (TBI) exhibit variance contingent upon biological sex. Although female sex hormones exert neuroprotective effects, the administration of estrogen and progesterone has not yielded conclusive results. Hence, it is conceivable that additional mediators, distinct from female sex hormones, merit consideration due to their potential differential impact on TBI outcomes. Calcitonin gene-related peptide (CGRP) exhibits sexually dimorphic expression and demonstrates neuroprotective effects in acute brain injuries. In this study, we aimed to examine sex-based variations in TBI structural and functional outcomes with respect to CGRP expression.
Methods
Male and female Sprague Dawley rats were exposed to controlled cortical impact to induce severe TBI, followed by interventions with and without CGRP inhibition. In the acute phase of TBI, the study centered on elucidating the influence of CGRP on oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) and endothelial nitric oxide synthase (eNOS) signaling in the peri-impact tissue. Subsequently, during the chronic phase of TBI, the investigation expanded to evaluate CGRP expression in relation to lesion volume, microvascular dysfunction, and white matter injury, as well as working and spatial memory, anxiety-like, and depression-like behaviors in subjects of both sexes.
Results
Female rats exhibited elevated levels of CGRP in the peri-impact brain tissue during both baseline conditions and in the acute and chronic phases of TBI, in comparison to age-matched male counterparts. Enhanced CGRP levels in specific brain sub-regions among female rats correlated with superior structural and functional outcomes following TBI compared to their male counterparts. CGRP inhibition induced heightened oxidative stress and a reduction in the expression of Nrf2 and eNOS in both male and female rats, with the observed alteration being more pronounced in females than in males.
Conclusions
This study marks the inaugural identification of CGRP as a downstream mediator contributing to the sexually dimorphic response observed in TBI outcomes.
Pulmonary glue embolism after radiological embolization of pelvic varices: A case report.
Authors: Longueville Elise , Dury Sandra , Ancel Julien , Attali Jonathan , Larad-Riffault Rahma , Pierrot Camille , Perotin Jeanne-Marie , Deslee Gaetan 
Published: February 2024

Abstract
Background: Non-thrombotic pulmonary embolism (NTPE) is defined as embolization in the pulmonary circulation of biological or non-biological substances and foreign bodies. The migration of glue in the pulmonary circulation during interventional procedures is unusual and has been reported mainly after gastroenterological procedures. The most severe cases of NTPE can be life-threatening.
Case presentation: A 31-year-old woman developed respiratory failure 24 hours after radiological embolization of pelvic varices. Glue embolization was detected during the intervention and was confirmed on a chest CT scan showing multiple bilateral hyperdense elements up to sub-pleural regions. The patient developed respiratory symptoms 24 hours after the procedure, progressively worsening with oxygen requirement up to 6 L/min. A follow-up chest CT angiography showed a thrombotic pulmonary embolism. Treatments included curative anticoagulation, antibiotherapy, corticosteroids, and oxygen, leading to improvement after 10 days of treatment.
Conclusions: This case report highlights that NTPE can occur after all interventional procedures using glue including pelvic procedures and can be complicated by thrombotic pulmonary embolism.
Prognostic Biomarkers for Delayed Cerebral Ischemia Post-Aneurysmal Subarachnoid Hemorrhage: Evaluating CSF 8-iso-Prostaglandin F2α and Erythrocyte Anisocytosis
Authors: Wiśniewski Karol , Zaczkowski Karol , Szmyd Bartosz , Popęda Marta , Bieńkowski Michał , Posmyk Bartłomiej , Bobeff Ernest Jan , Jaskólski Dariusz J. 
Published: February 2024

Abstract
Background
Delayed cerebral ischemia (DCI) is a serious, life-threatening, complication affecting patients who have survived the initial bleeding from a ruptured intracranial aneurysm. Due to the challenging diagnosis, potential DCI prognostic markers should be of value in clinical practice. According to recent reports isoprostanes and red blood cell distribution (RDW) showed to be promising in this respect.
Methods
We conducted a prospective study with a control group (n=8), recruiting aSAH patients (n=27), who underwent surgery within the first day of the initial bleeding. We collected data regarding clinical status and results of biochemical, and radiological examinations. We measured cerebrospinal fluid (CSF) concentration of 8-iso-prostaglandin F2α (F2-IsoP) and RDW on day 1, 3, and 5.
Results
Both CSF F2-IsoP level and RDW measured on day 1 were significant predictors of DCI. The receiver operating characteristics curve for DCI prediction based on the multivariate model yielded an area under the curve (AUC) of 0.924 (95%CI: 0.824-0.1, p<0.01).
Conclusions
In our study, the model based on the combination of RDW and the level of isoprostanes in CSF on the first day after the initial bleeding showed a prognostic value for DCI prediction. Further studies are required to validate this observation.
Chloroplast Genome Analysis and Evolutionary Insights in the Versatile Medicinal Plant Calendula officinalis L
Authors: Zhang Ningyun , Huang Kerui , Xie Peng , Deng Aihua , Jiang Ming , Mo Ping , Yin Hanbin , Tang Xuan , Huang Rongjie , Liang Jiale , He Fuhao , Hu Haoliang , Wang Yun 
Published: February 2024

Abstract

Calendula officinalis L.is a versatile medicinal plant with numerous applications in various fields. However, its chloroplast genome structure, features, phylogeny, and patterns of evolution and mutation remain largely unexplored. This study examines the chloroplast genome, phylogeny, codon usage bias, and divergence time of C. officinalis, enhancing our understanding of its evolution and adaptation. The chloroplast genome of C. officinalis is a 150,465 bp circular molecule with a G+C content of 37.75% and comprises 131 genes. Phylogenetic analysis revealed a close relationship between C. officinalis, C. arvensis, and Osteospermum ecklonis. A key finding is the similarity in codon usage bias among these species, which, coupled with the divergence time analysis, supports their close phylogenetic proximity. This similarity in codon preference and divergence times underscores a parallel evolutionary adaptation journey for these species, highlighting the intricate interplay between genetic evolution and environmental adaptation in the Asteraceae family.
Establishing the distribution of cerebrovascular resistance using computational fluid dynamics and 4D flow MRI
Authors: Vikström Axel , Holmlund Petter , Holmgren Madelene , Wåhlin Anders , Zarrinkoob Laleh , Malm Jan , Eklund Anders 
Published: February 2024

Abstract
Cerebrovascular resistance (CVR) regulates blood flow in the brain, but little is known about the vascular resistances of the individual cerebral territories. We present a method to calculate these resistances and investigate how CVR varies in the hemodynamically disturbed brain. We included 48 patients with stroke/TIA (29 with symptomatic carotid stenosis). By combining flow rate (4D flow MRI) and structural computed tomography angiography (CTA) data, and using computational fluid dynamics (CFD) we computed the perfusion pressures out from the circle of Willis, with which CVR of the MCA, ACA, and PCA territories was estimated. 56 controls were included for comparison of total CVR. CVR were 33.8 ± 10.5, 59.0 ± 30.6, and 77.8 ± 21.3 mmHg·s/ml for the MCA, ACA, and PCA territories. We found no differences in total CVR between patients, 9.3 ± 1.9 mmHg·s/ml, and controls, 9.3 ± 2.0 mmHg·s/ml (p = 0.88), nor in territorial CVR in the carotid stenosis patients between ipsilateral and contralateral hemispheres. Territorial resistance associated inversely to territorial brain volume (p < 0.001). These resistances may work as reference values when modelling blood flow in the circle of Willis, and the method can be used when there is need for subject-specific analysis.
Ring Current Local Time Dependence during geomagnetic storms using equatorial Dst - proxies
Authors: Pinzon-Cortes Santiago , Gómez-Pérez Natalia , Domínguez Santiago Vargas 
Published: February 2024

Abstract

Monitoring geomagnetic activity is essential for predicting and mitigating the impacts of space weather on our planet. Damages to infrastructure, GPS failures, communication disruptions, and electrical power blackouts, as well as enhanced decay of satellites' orbits, may all be a consequence of intense geomagnetic storms. To be able to mitigate geomagnetic storms impact, we can study magnetospheric equatorial currents by monitoring storms effect at low latitudes and ground level. In this paper, we calculate Local Disturbance indices (LDi) using data from two equatorial observatories (Ascension ASC and Fúquene FUQ) to use them as Dst-index proxies. We find that the LDi response to geomagnetic storms is different depending on the observatory's local time at the storm onset. In order to explore this local time influence on the measurements on the ground at low latitudes, we build new proxies using two observatories located at approximately the same longitude. The average of the longitude pairs exhibit strong correlation to the Dst index (≥ 0.88) during active periods and a moderate correlation (≥ 0.5) during quiet periods. We find that the storm intensity is associated with local time. We confirm that the fastest variation in the geomagnetic field during the storm is recorded between dusk and midnight, while the region between dawn and noon records more moderate variations, sometimes missing the storm effects altogether. Our results show an azimuthal asymmetry of the magnetospheric ring current, becoming most intense on the night side of the dusk terminator during active periods. We suggest that a global index is not enough to characterise the risk from geomagnetic storms. A local-time dependent index could be used, and good local time coverage of the equatorial magnetic field is important to better quantify and forecast possible impacts to infrastructure on Earth and space.
Is There a Correlation Between Physical Properties and Film Thickness of Dual- and Photo- polymerized Luting Resins and CAD/CAM-Dentin Micro-Tensile Bond Strength?
Authors: El-Askary Farid , Tadros Nader , Hassanien Abdullah , Aboalazm Emad , Kamel Mohamed Amr , Özcan Mutlu 
Published: February 2024

Abstract
Objective To correlate µTBS of photo- and dual-polymerized luting resins with film thickness (FT), Vicker's hardness (HV) and ultimate-tensile strength (UTS).Methods Human molars (N = 30) were divided (6-groups) according to: 1: Luting resin: Dual- [Bifix QM, (BF)], or photo-polymerized [GrandioSo Heavy Flow (GHF) and VisCalor Bulk (VB)] and 2: Adhesive mode (Optibond Universal): Etch-and-rinse (ER) or self-etching (SE). CAD/CAM blocks (7x7x4mm3) were air-abraded (50µm Al2O3/10s/0.2MPa) and silanated. For ER, dentin was etched (15s), rinsed (30s), and blot-dried. For both modes, adhesive was applied (20s), air-dried (5s) and photo-polymerized (10s). Sticks (1x1mm2) were aged either for 24-hours or for 6-months. Sticks were pulled in tension (1mm/min). Debonded sticks were evaluated for failure mode. For FT, nine-bonded slabs/each cement were evaluated. For UTS, eight-hourglass specimens/each cement were tested. For HV, 5-discs/each cement were evaluated using Vicker’s hardness tester. Data were analysed using ANOVA/Pearson's correlation tests (α = 0.05).Results No correlation between µTBS/HV was revealed (P > 0.05). Positive correlation between µTBS/FT and µTBS/UTS (p < 0.05) were observed. Three-Way ANOVA revealed all experimental factors had significant effect on µTBS (p < 0.05). The VB showed significant lower µTBS (20.8 ± 9.3MPa). The ER mode showed higher µTBS (26.0 ± 10.9MPa), and 24-hours revealed the higher µTBS (27.4 ± 10.0MPa). Mixed failure was the predominate type (42.51%). The VB showed the highest FT (122.2 ± 11.9µm). The GHF revealed higher UTS and HV (112.5 ± 19.7MPa and 91.6 ± 0.4Kgf respectively).Conclusions Photo-polymerized flowable resin can substitute dual-polymerized cement for CAD/CAM composite bonding.Clinical relevance: Photo-polymerized flowable composite can replace the dual-polymerized resin cement one to bond CAD/CAM composite to dentin.