bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships Among Physical Activity, Sleep, and Cancer-related Fatigue: Results From the International ColoCare Study
Authors: Crowder Sylvia L , Li Xiaoyin , Himbert Caroline , Viskochil Richard , Hoogland Aasha I , Gudenkauf Lisa M , Oswald Laura B , Gonzalez Brian D , Small Brent J , Ulrich Cornelia M , Ose Jennifer , Peoples Anita R , Li Christopher I , Shibata David , Toriola Adetunji T , Gigic Biljana , Playdon Mary C , Hardikar Sheetal , Bower Julienne , Siegel Erin M , Figueiredo Jane C , Jim Heather S L 
Published: December 2023

Abstract

Background
Risk factors for cancer-related fatigue are understudied in colorectal cancer.

Purpose
This study aimed to address this critical gap in the literature by (a) describing changes in colorectal cancer-related fatigue and health behavior (physical activity, sleep problems) and (b) examining if physical activity and sleep problems predict fatigue trajectories from baseline (approximately at the time of diagnosis), to 6- and 12 months after enrollment.

Methods
Patients participating in the international ColoCare Study completed self-report measures at baseline (approximately time of diagnosis), 6-, and 12 months assessing physical activity using the International Physical Activity Questionnaire (IPAQ) and fatigue and sleep using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30). Mixed-effect models examined changes in physical activity, sleep problems, and fatigue. Cross-lagged panel models examined bidirectional relationships between physical activity or sleep and fatigue across time.

Results
Colorectal cancer patients (n = 649) had a mean age of 61 ± 13 years. Most were male (59%), non-Hispanic White (91%), diagnosed with Stages III–IV (56%) colon cancer (58%), and treated with surgery (98%). Within-person cross-lagged models indicated higher physical activity at Month 6 was associated with higher fatigue at Month 12 (β = 0.26, p = .016). When stratified by cancer stage (I–II vs. III–IV), the relationship between physical activity at Month 6 and fatigue at Month 12 existed only for patients with advanced cancer (Stages III and IV, β = 0.43, p = .035). Cross-lagged associations for sleep and fatigue from baseline to Month 6 were only observed in patients with Stages III or IV cancer, however, there was a clear cross-sectional association between sleep problems and fatigue at baseline and Month 6.

Conclusions
Within-person and cross-lagged association models suggest fatiguability may become increasingly problematic for patients with advanced colorectal cancer the first year after diagnosis. In addition, sleep problems were consistently associated with higher fatigue in the first year, regardless of cancer stage.

Trial registration
The international ColoCare Study was registered on clinicaltrials.gov, NCT02328677, in December 2014.
Implementation of a technician success and onboarding coordinator to reduce technician turnover
Authors: Arrona Kimberly L 
Published: December 2023

Abstract

Purpose
This article provides an overview of changes implemented at an academic medical center to reduce pharmacy technician turnover.

Summary
Pharmacy technician turnover has been a problem for years. Technicians come and go; they move on to other positions, and continuous turnover is an avoidable expense. With greater focus on creating a successful onboarding experience for newly hired technicians, turnover should decrease and satisfaction and engagement should increase. When a newly hired technician leaves a department within the first year, it can have a negative impact on the engagement of the remaining technicians who spent time training new hires in how to complete tasks, mentoring them, and incorporating them into the team. Creating a positive onboarding experience will decrease expenses accrued and minimize wasted resources and staff time dedicated to a technician who will not be around in 6 months to 1 year. At M Health Fairview, a Minneapolis, MN–based health system, technician retention has been improved through a standardized approach to onboarding and orientation, including creation of the new staff role of technician success and onboarding coordinator (TSOC).

Conclusion
A standard approach to onboarding pharmacy technicians and integrating them into the pharmacy department has proven to be essential to technician retention at M Health Fairview. To get started, it is important to find the right person for the TSOC role to coordinate successful onboarding of newly hired pharmacy technicians. That person should be an individual with passion to engage and inspire newly hired technicians, with several years of experience, and with the ability to cascade knowledge.
Effects of experimental warming on floral scent, display and rewards in two subalpine herbs
Authors: Wu Carrie , Powers John M , Hopp David Z , Campbell Diane R 
Published: December 2023

Abstract

Background and Aims
Floral volatiles, visual traits and rewards mediate attraction and defence in plant–pollinator and plant–herbivore interactions, but these floral traits might be altered by global warming through direct effects of temperature or longer-term impacts on plant resources. We examined the effect of warming on floral and leaf volatile emissions, floral morphology, plant height, nectar production, and oviposition by seed predators.

Methods
We used open-top chambers that warmed plants in the field by +2–3 °C on average (+6–11 °C increase in daily maxima) for 2–4 weeks across 1–3 years at three sites in Colorado, USA. Volatiles were sampled from two closely related species of subalpine Ipomopsis with different pollinators: Ipomopsis aggregata ssp. aggregata, visited mainly by hummingbirds, and Ipomopsis tenuituba ssp. tenuituba, often visited by hawkmoths.

Key Results
Although warming had no detected effects on leaf volatiles, the daytime floral volatiles of both I. aggregata and I. tenuituba responded in subtle ways to warming, with impacts that depended on the species, site and year. In addition to the long-term effect of warming, temperature at the time of sampling independently affected the floral volatile emissions of I. aggregata during the day and I. tenuituba at night. Warming had little effect on floral morphology for either species and it had no effect on nectar concentration, maximum inflorescence height or flower redness in I. aggregata. However, warming increased nectar production in I. aggregata by 41 %, a response that would attract more hummingbird visits, and it reduced oviposition by fly seed predators by ≥72 %.

Conclusions
Our results suggest that floral traits can show different levels of plasticity to temperature changes in subalpine environments, with potential effects on animal behaviours that help or hinder plant reproduction. They also illustrate the need for more long-term field warming studies, as shown by responses of floral volatiles in different ways to weeks of warming vs. temperature at the time of sampling.
Paternal leakage of plastids rescues inter-lineage hybrids in Silene nutans
Authors: Postel Zoé , Van Rossum Fabienne , Godé Cécile , Schmitt Eric , Touzet Pascal 
Published: December 2023

Abstract

Background and Aims
Organelle genomes are usually maternally inherited in angiosperms. However, biparental inheritance has been observed, especially in hybrids resulting from crosses between divergent genetic lineages. When it concerns the plastid genome, this exceptional mode of inheritance might rescue inter-lineage hybrids suffering from plastid–nuclear incompatibilities. Genetically differentiated lineages of Silene nutans exhibit strong postzygotic isolation owing to plastid–nuclear incompatibilities, highlighted by inter-lineage hybrid chlorosis and mortality. Surviving hybrids can exhibit variegated leaves, which might indicate paternal leakage of the plastid genome. We tested whether the surviving hybrids inherited the paternal plastid genome and survived thanks to paternal leakage.

Methods
We characterized the leaf phenotype (fully green, variegated or white) of 504 surviving inter-lineage hybrids obtained from a reciprocal cross experiment among populations of four genetic lineages (W1, W2, W3 and E1) of S. nutans from Western Europe and genotyped 560 leaf samples (both green and white leaves for variegated hybrids) using six lineage-specific plastid single nucleotide polymorphisms.

Key Results
A high proportion of the surviving hybrids (≤98 %) inherited the paternal plastid genome, indicating paternal leakage. The level of paternal leakage depended on cross type and cross direction. The E1 and W2 lineages as maternal lineages led to the highest hybrid mortality and to the highest paternal leakage from W1 and W3 lineages in the few surviving hybrids. This was consistent with E1 and W2 lineages, which contained the most divergent plastid genomes. When W3 was the mother, more hybrids survived, and no paternal leakage was detected.

Conclusions
By providing a plastid genome potentially more compatible with the hybrid nuclear background, paternal leakage has the potential to rescue inter-lineage hybrids from plastid–nuclear incompatibilities. This phenomenon might slow down the speciation process, provided hybrid survival and reproduction can occur in the wild.
When Athens invaded Denmark: reading Thucydides before and during the Second World War
Authors: Kopp Hans 
Published: December 2023

Abstract
The Danish politician Hartvig Frisch’s reading of Thucydides at the eve of and during the Second World War is a particularly illuminating example of the modern reception of the Athenian historian. This is not due to any peculiar character of his interpretation, which scarcely differs from other contemporary accounts of the History of the Peloponnesian War as a lesson in seeing the world ‘realistically’. Rather, it is due to Frisch’s eagerness to make the text meaningful in a very practical sense. Addressing fellow socialist politicians, working-class youths, and students alike, and drawing parallels between the situation of his native Denmark and the fate of the Greek island town of Melos in 416 bce, Frisch saw Thucydides’ History as an invaluable guide for the demanding times of the late 1930s and 1940s, in particular for the inhabitants of ‘small nations’ like his own.
scDMV: a zero–one inflated beta mixture model for DNA methylation variability with scBS-seq data
Authors: Zhou Yan , Zhang Ying , Peng Minjiao , Zhang Yaru , Li Chenghao , Shu Lianjie , Hu Yaohua , Su Jianzhong , Xu Jinfeng 
Published: December 2023

AbstractMotivationThe utilization of single-cell bisulfite sequencing (scBS-seq) methods allows for precise analysis of DNA methylation patterns at the individual cell level, enabling the identification of rare populations, revealing cell-specific epigenetic changes, and improving differential methylation analysis. Nonetheless, the presence of sparse data and an overabundance of zeros and ones, attributed to limited sequencing depth and coverage, frequently results in reduced precision accuracy during the process of differential methylation detection using scBS-seq. Consequently, there is a pressing demand for an innovative differential methylation analysis approach that effectively tackles these data characteristics and enhances recognition accuracy.ResultsWe propose a novel beta mixture approach called scDMV for analyzing methylation differences in single-cell bisulfite sequencing data, which effectively handles excess zeros and ones and accommodates low-input sequencing. Our extensive simulation studies demonstrate that the scDMV approach outperforms several alternative methods in terms of sensitivity, precision, and controlling the false positive rate. Moreover, in real data applications, we observe that scDMV exhibits higher precision and sensitivity in identifying differentially methylated regions, even with low-input samples. In addition, scDMV reveals important information for GO enrichment analysis with single-cell whole-genome sequencing data that are often overlooked by other methods.Availability and implementationThe scDMV method, along with a comprehensive tutorial, can be accessed as an R package on the following GitHub repository: https://github.com/PLX-m/scDMV.
TEFDTA: a transformer encoder and fingerprint representation combined prediction method for bonded and non-bonded drug–target affinities
Authors: Li Zongquan , Ren Pengxuan , Yang Hao , Zheng Jie , Bai Fang 
Published: December 2023

Abstract

Motivation
The prediction of binding affinity between drug and target is crucial in drug discovery. However, the accuracy of current methods still needs to be improved. On the other hand, most deep learning methods focus only on the prediction of non-covalent (non-bonded) binding molecular systems, but neglect the cases of covalent binding, which has gained increasing attention in the field of drug development.

Results
In this work, a new attention-based model, A Transformer Encoder and Fingerprint combined Prediction method for Drug–Target Affinity (TEFDTA) is proposed to predict the binding affinity for bonded and non-bonded drug–target interactions. To deal with such complicated problems, we used different representations for protein and drug molecules, respectively. In detail, an initial framework was built by training our model using the datasets of non-bonded protein–ligand interactions. For the widely used dataset Davis, an additional contribution of this study is that we provide a manually corrected Davis database. The model was subsequently fine-tuned on a smaller dataset of covalent interactions from the CovalentInDB database to optimize performance. The results demonstrate a significant improvement over existing approaches, with an average improvement of 7.6% in predicting non-covalent binding affinity and a remarkable average improvement of 62.9% in predicting covalent binding affinity compared to using BindingDB data alone. At the end, the potential ability of our model to identify activity cliffs was investigated through a case study. The prediction results indicate that our model is sensitive to discriminate the difference of binding affinities arising from small variances in the structures of compounds.

Availability and implementation
The codes and datasets of TEFDTA are available at https://github.com/lizongquan01/TEFDTA.
BKCa channels are involved in spontaneous and lipopolysaccharide-stimulated uterine contraction in late gestation mice
Authors: Bao Junjie , Ma Xiaofeng , Kent Lindsey N , Wakle-Prabagaran Monali , McCarthy Ronald , England Sarah K 
Published: December 2023

Abstract
The large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) is one of the most abundant potassium channels in the myometrium. Previous work conducted by our group has identified a link between inflammation, BKCa channels and excitability of myometrial smooth muscle cells. Here, we investigate the role of BKCa channels in spontaneous and lipopolysaccharide (LPS)-stimulated uterine contraction to gain a better understanding of the relationship between the BKCa channel and uterine contraction in basal and inflammatory states. Uteri of C57BL/6 J mice on gestational day 18.5 (GD18.5) were obtained and either fixed in formalin or used immediately for tension recording or isolation of primary myocytes for patch-clamp. Paraffin sections were used for immunofluorescenctdetection of BKCa and Toll-like receptor (TLR4). For tension recordings, LPS was administered to determine its effect on uterine contractions. Paxilline, a BKCa inhibitor, was used to dissect the role of BKCa in uterine contraction in basal and inflammatory states. Finally, patch-clamp recordings were performed to investigate the relationship between LPS, the BKCa channel and membrane currents in mouse myometrial smooth muscle cells (mMSMCs). We confirmed the expression of BKCa and TLR4 in the myometrium of GD18.5 mice and found that inhibiting BKCa channels with paxilline suppressed both spontaneous and LPS-stimulated uterine contractions. Furthermore, application of BKCa inhibitors (paxilline or iberiotoxin) after LPS inhibited BKCa channel activity in mMSMCs. Moreover, pretreatment with BKCa inhibitor or the TLR4 inhibitor suppressed LPS-activated BKCa currents. Our study demonstrates that BKCa channels are involved in both basal and LPS-stimulated uterine contraction in pregnant mice.
Long non-coding RNAs: a summary of their roles in placenta development and pathology
Authors: Adu-Gyamfi Enoch Appiah , Cheeran Elisha Ann , Salamah Joudi , Enabulele Divine Blessing , Tahir Ayesha , Lee Bum-Kyu 
Published: December 2023

Abstract
Long non-coding RNAs are cellular transcripts that have ˃200 nucleotides in length and do not code for proteins. Due to their low expression levels, long non-coding RNAs were previously considered as mere transcriptional noise. However, current evidence indicates that they regulate a myriad of biological processes such as cell proliferation, invasion, and apoptosis. Hence, their expression patterns are crucial indicators of the physiological or pathological states of cells, tissues, and organs. The utilization of long non-coding RNAs as biomarkers and therapeutic targets for the clinical management of several diseases have been suggested. Gradually, long non-coding RNAs are gaining a substantial attention in the field of feto-maternal medicine. After embryo implantation, the interactions between the trophoblast cells from the embryo and the uterus of the mother facilitate placenta development and pregnancy progression. These processes are tightly regulated, and their impairments result in pregnancy pathologies such as miscarriage and preeclampsia. Accumulating evidence implicates long non-coding RNAs in these processes. Herein, we have summarized the roles of several long non-coding RNAs in human placenta development, have proposed some mechanisms by which they participate in physiological and pathological placentation, have revealed some knowledge deficits, and have recommended ideal experimental approaches that will facilitate the clarification of the mechanistic actions of each long non-coding RNA at the feto-maternal interface during healthy and pathological pregnancies.
Polypharmacy Is Associated With Slow Gait Speed and Recurrent Falls in Older People With HIV
Authors: Kosana Priya , Wu Kunling , Tassiopoulos Katherine , Letendre Scott , Ma Qing , Paul Robert , Ellis Ronald , Erlandson Kristine M , Farhadian Shelli F 
Published: December 2023

Abstract

Background
Older people with human immunodeficiency virus (HIV, PWH) are prone to using multiple medications due to higher rates of medical comorbidities and the use of antiretroviral therapy (ART). We assessed the prevalence and clinical impact of polypharmacy among PWH.

Methods
We leveraged clinical data from the AIDS Clinical Trials Group A5322 study “Long-Term Follow-up of Older HIV-infected Adults: Addressing Issues of Aging, HIV Infection and Inflammation” (HAILO). We included PWH aged ≥40 years with plasma HIV RNA levels &lt;200 copies/µL. We assessed the relationship between polypharmacy (defined as the use of 5 or more prescription medications, excluding ART) and hyperpolypharmacy (defined as the use of 10 or more prescription medications, excluding ART) with slow gait speed (less than 1 meter/second) and falls, including recurrent falls.

Results
Excluding ART, 24% of study participants had polypharmacy and 4% had hyperpolypharmacy. Polypharmacy was more common in women (30%) than men (23%). Participants with polypharmacy had a higher risk of slow gait speed (odds ratio [OR] = 1.78; 95% confidence interval [CI] = 1.27–2.50) and increased risk of recurrent falls (OR = 2.12; 95% CI = 1.06–4.23). The risk for recurrent falls was further increased in those with hyperpolypharmacy compared with those without polypharmacy (OR = 3.46; 95% CI = 1.32–9.12).

Conclusions
In this large, mixed-sex cohort of PWH aged ≥40 years, polypharmacy was associated with slow gait speed and recurrent falls, even after accounting for medical comorbidities, alcohol use, substance use, and other factors. These results highlight the need for increased focus on identifying and managing polypharmacy and hyperpolypharmacy in PWH.
Three types of income inequality: a comparison of left behind places and more developed regions in the EU
Authors: Faggian Alessandra , Michelangeli Alessandra , Tkach Kateryna 
Published: December 2023

AbstractDespite the growing interest in subjective inequality, little is known about the relation between this and more objective measures of inequality, especially in the light of regional disparities. This study focuses on the patterns of actual income inequality and two subjective measures in NUTS 2 EU regions. By accounting for multiple indicators of economic (under)performance, we show that actual inequality is positively related to people’s perceptions in left behind places, but not in more developed regions. Furthermore, both residents of less developed or—‘left behind’—regions and those of more developed regions exhibit a preference for lower levels of income inequality.
A generative hypergraph model for double heterogeneity
Authors: Li Zhao , Zhang Jing , Zheng Guozhong , Chen Li , Zhang Jiqiang , Cai Weiran 
Published: December 2023

Abstract
While network science has become an indispensable tool for studying complex systems, the conventional use of pairwise links often shows limitations in describing high-order interactions properly. Hypergraphs, where each edge can connect more than two nodes, have thus become a new paradigm in network science. Yet, we are still in lack of models linking network growth and hyperedge expansion, both of which are commonly observable in the real world. Here, we propose a generative hypergraph model by employing the preferential attachment mechanism in both nodes and hyperedge formation. The model can produce bi-heterogeneity, exhibiting scale-free distributions in both hyperdegree and hyperedge size. We provide a mean-field treatment that gives the expression of the two scaling exponents, which agree with the numerical simulations. Our model may help to understand the networked systems showing both types of heterogeneity and facilitate the study of complex dynamics thereon.
Concomitant treatment of sustained ventricular tachycardia and hypertrophic cardiomyopathy with transcoronary ethanol ablation: a case report
Authors: Xia Eric T , Lee Kevin , Minga Iva , Nazari Jose , Metzl Mark D 
Published: December 2023

Abstract

Background
The recommended treatment for recurrent ventricular tachycardia in patients with hypertrophic cardiomyopathy that is not amenable to defibrillator implantation due to shock burden is radiofrequency ablation. In patients with deeply intramural foci of ventricular tachycardia, traditional unipolar ablation has a lower probability of success.

Case summary
A 66-year-old Caucasian man was admitted with ventricular tachycardia, which recurred despite antiarrhythmic drugs. On cardiac magnetic resonance imaging, he was discovered to have septal hypertrophic cardiomyopathy, which was not significant on echocardiogram. The focus of ventricular tachycardia was suspected to be buried deeply within the hypertrophic segment as localized by late gadolinium enhancement. The patient underwent transcoronary ethanol ablation, which abated the ventricular tachycardia while also completely decreasing his invasively measured left ventricular outflow tract obstruction gradient from 45 to 17 mmHg.

Discussion
Transcoronary ethanol ablation may be successfully applied to simultaneously treat ventricular arrhythmia superimposed within a segment of hypertrophic cardiomyopathy. Further data are needed to evaluate long-term success of this strategy vs. traditional radiofrequency ablation.