bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outbreak of malaria in southern Iran: How could manage this disease?
Authors: khammarnia Mohammad , Peyvand Mostafa , Barfar Esagh , Setoodehzadeh Fatemeh , Kargar Shiva , Rokni Iman 
Published: October 2023

Abstract
Background
Iran is considered one of the countries with high rates of malaria, particularly in its southern and southeastern regions. In 2009, Iran initiated a program aimed at eliminating malaria by 2025. Proper management of the disease requires a complete knowledge of the disease. The objective of this study was to examine the malaria situation in southern Iran from 2016 to 2023.
Method
A cross-sectional study was carried out in Sistan-Baluchistan province as the second largest province of Iran in 2023. The clinical and demographical data were collected for the three medical universities from March 2016 to March 2023. The census method for selecting the study population was used. Demographic, population, parasitology, and epidemiology variables were investigated. Data was entered and analyzed using SPSS 25. Analytical tests such as T-test and one-way analysis of variance (ANOVA) were used. A 95% confidence interval and p-value less than 0.05 were considered.
Results
According to the results, from 2016 to March 2023 about 8389 cases of malaria were diagnosed by the health care system in the southeast of Iran. Most of these cases (77.4%) were reported in the southernmost region of Iran. َAlso, 78% of malaria cases occurred in individuals of Iranian nationality. An overwhelming majority of patients (94.7%) had no prior history of malaria infection. The highest occurrence of the disease was in men and this difference was significant (P = 0.001). Furthermore, 44.8% of the patients were border drivers. The occurrence of malaria cases in the region was relatively low between 2016 and 2018. However, it started to increase from 2019 onwards and reached the highest rate in 2022. The most of malaria cases during the last Iranian year were concentrated in the border cities of Rask and Saravan, which are adjacent to Pakistan. Additionally, 80% of the patients were infected with the Plasmodium vivax type of malaria parasite.
Conclusion
To effectively manage malaria in malaria-prone areas like Sistan-Baluchistan province, health decision-makers should focus on prompt treatment of malaria patients, prevention of mosquito circulation, raising awareness about malaria symptoms (especially among men working at borders), and monitoring the health of individuals who frequently travel to Pakistan.
A corpus-based study on the influence of different Chinese proficiency levels on the types of lexical errors in Korean students’ Chinese writing
Authors: Wen Ziying 
Published: October 2023

Abstract
Corpus linguistics has been widely used in interlanguage research, and most of the interlanguage corpus studies on error analysis studies focus on one-word, lexical categories of individual words, or lexical categories of individual countries. In the process of international students learning Chinese, the acquisition of Chinese vocabulary will be different at different levels of Chinese proficiency. Therefore, this study will be conducted by this research field by selecting the Chinese writing annotation error analysis texts and related corpus data of international and Korean students with different Chinese proficiency levels from the Global Chinese Interlanguage Corpus. Through linear regression analysis, it is found that there is a certain correlation between Chinese proficiency and the frequency of some lexical deviations, including two types of lexical deviations, namely, missing words and incomplete constituents. Among them, missing word is the type of lexical error in writing that distinguishes Korean students from other international students. Through textual analysis, the dynamic development of Korean international students' Chinese interlanguage system is further explored.
Influence of Franz Keldysh Effect on the Modulation depth and Distortion Characteristics of Transistor Laser
Authors: Ramya R. , Piramasubramanian S. , Madhan M Ganesh 
Published: October 2023

Abstract

Numerical analysis of a Transistor Laser is carried out to investigate the influence of Franz-Keldysh Effect on the non-linear distortion characteristics such as intermodulation (IM). The device considered for the study incorporates a GaAs absorber layer in the collector–base junction of a TL emitting around 980 nm. The base current threshold is obtained as 39 mA for the collector to base voltage of 1 V and it is discerned that the threshold current of TL is dependent on electric field in addition to the bias current. The analytical solution of rate equations at steady state is derived and compared with the numerical simulation and the same is plotted for VCB = 1 V. Moreover, maximum optical light output loss of 12 mW and 1.37 mA additional current is contributed to the collector current for collector base voltage of 3 V under various base currents due to F-K effect. The modulation bandwidth (f− 3dB) of TL under voltage modulation is obtained as 9.63 GHz while, under current modulation, it is found as 8.38 GHz respectively. A maximum modulation depth of 86% is obtained for IB=1.06Ith, at 2.4 GHz. The frequency components related to intermodulation product, IMD3 (2.15 GHz) magnitudes are obtained as − 10.26dBc, − 12.37 dBc, − 13.54 dBc and − 15.92 dBc for VCB voltage value of 0V, 1V, 2V and 3V respectively. The intermodulation product, IMD5 (2.05 GHz)magnitudes are obtained as − 18.89 dBc,−25.76 dBc, − 28.22 dBc and − 36.05 dBc for the collector bias voltage (VCB) value of 0V, 1V, 2V and 3V respectively.
Involvement of prohibitins in an oncogenic protein complex in Chronic Lymphocytic Leukemia
Authors: Gallet Paul-Francois , Ikhlef Lea , Franklin Valar Roamio , D'Santos Clive , Gachard Nathalie , Dmytruk Natalya , Jauberteau Marie-Odile 
Published: October 2023

Abstract
Prohibitins (PHB1 and PHB2) are highly conserved and ubiquitously expressed proteins that are mainly localized in the mitochondria. They have been reported to have multiple functions, which can vary depending on their cellular localization and cell type. They are implicated in several critical cellular processes, including proliferation, functional integrity of mitochondria, cell survival, and apoptosis. Recently, research has highlighted the potential role of prohibitins in cancer pathogenesis, notably in some hematological malignancies. However, their mechanisms of action remain largely misunderstood. In this study, we report the involvement of prohibitins in a previously identified oncogenic protein complex in Chronic Lymphocytic Leukemia (CLL) involving NTSR2, a low-affinity G protein-coupled receptor for neurotensin, and TrkB, a receptor for brain-derived neurotrophic factor (BDNF). We evidenced the overexpression of prohibitins in CLL patients B cells compared to healthy donors PBMCs and demonstrated the interaction of PHB1 and PHB2 with the oncogenic protein complex. We also showed that prohibitins regulate NTSR2 expression, potentially via its interaction with transcription factors and that selective prohibitin inhibition affects downstream NTSR2/TrkB signaling. Overall, these findings suggest a role of prohibitins in CLL pathogenesis and their potential as disease biomarkers or therapeutic targets.
A scoping review of factors influencing prosthesis selection for knee and hip arthroplasties: perspectives of surgeons in high income countries
Authors: Allen Michelle J , Selim Shayma Mohammed , Senanayake Sameera , Brain David , Blythe Robin , Hinchcliff Reece , McCreanor Victoria , Kularatna Sanjeewa , Elliott Lana , McPhail Steven M 
Published: October 2023

Abstract
Purpose
Hip and knee arthroplasties in high income countries are common and costly. A substantial proportion of the costs associated with these surgeries are attributable to the prosthesis chosen by surgeons. The objective of this scoping review was to identify ‘What are the factors influencing surgeons’ prosthesis selection for knee and hip arthroplasty in high-income countries?’
Methods
Four databases of peer reviewed literature (Embase, PubMed, CINAHL, and Web of Science) and two grey literature searches (Policy Commons and Overton) were conducted. Papers were included if they evaluate opinions or experiences of surgeons concerning prosthesis selection for hip or knee arthroplasty and published in English. Factors influencing prosthesis selection were categorised into the domains of patient advantage, surgeon-related, prosthesis quality, vendor or service-related, cost considerations, and information source.
Results
A total of 2572 unique articles were identified and screened, four studies were eligible for inclusion. Consideration of cost and patient benefit were noted across included studies. Several other factors were outlined including familiarity with prostheses, relationship with the vendor, or prosthesis reputation, but the relative extent to which these factors contribute to decision making is unclear.
Conclusion
Despite a relative scarcity of studies investigating factors influencing surgeon’s prosthesis selection choices, multiple factors were identified for further exploration. A greater understanding the perspectives of surgeons is needed for the effective development and implementation of any hospital or system-level policies for reducing arthroplasty costs and improving patient outcomes.
Mapping capabilities of geometric EM induction sounding in southern Yakutia permafrost
Authors: Neradovskii L. G. 
Published: October 2023

The purpose of the article is to consider the possibilities of the geophysical method in solving the problem of quantitative estimation of the strength of sedimentary rocks that form the basis of engineering structures at the Kyurgellakh station of the Amur-Yakutsk Railway located 572 km away from the town of Neryungri, which is an administrative center of southern Yakutia (Russia). The problem is solved using the method of geometric electromagnetic induction sounding and a new technique that explored the attenuation of the harmonic field induced by a vertical magnetic dipole in the inhomogeneous anisotropic geological medium at the frequencies of 1.125 and 0.281 MHz in the intermediate separation zone of 5–100 m. A comparative analysis has determined a good agreement in changes of geological and geophysical estimates of the average strength of laboratory water-saturated samples and sedimentary rock mass predicted in the same state at the comparable depth of 6–12 m. The measure of agreement when using the most adequate equation of the power function is high and equals 0.815 according to the normalized coefficient of multiple determination. This means that strength is the most important factor among the frozen ground characteristics affecting the electromagnetic field attenuation at the frequencies and spacing specified, contributing no less than 80 %. The tested geophysical method can thus correctly map the distribution boundaries of different strength sedimentary rocks. The crushed and fissured rocks with the strengths below 40–35 MPa are confined to the tectonic fractures of varying directions with a polygon-like structure. Geophysical data clearly delineate the structure at the depths of 12.3–27.5 m where predominate the rocks with high strengths (50–120 MPa). The geometric EM induction sounding is recommended to use at all stages of geotechnical investigations to map the development areas of southern Yakutia by rock strength classes.
Assessing crop–livestock water productivity in mixed-farming systems across climatic zones of Burkina Faso
Authors: Sanou Charles Lamoussa , Agodzo Sampson Kwaku , Bessah Enoch , Antwi-Agyei Philip 
Published: October 2023

Abstract

Climate change adversely impacts food and feed production, depletes water, and increases the vulnerability of the people living within arid and semi-arid areas. The current study aims to assess crop–livestock water productivity within such drought-recurrent or water-stressed regions. This was done through secondary data collection and interviews from 589 households across the Sudan, Sudan–Sahel, and Sahel climatic zones of Burkina Faso. The findings confirm that the feeding strategies of livestock were based essentially on natural pasture, crop residues, and agricultural by-products. Moreover, crop–livestock total water productivity (TWP) was found generally higher in the Sudan zone (0.29 ± 0.02 $US/m3) characterized by more favorable climatic conditions than the Sudan–Sahel and Sahel regions that experienced a similar TWP (0.21 ± 0.01 $US/m3). The research gives insight into the valuation of virtual water contained in livestock feeds. Improving the accessibility in quantity and quality of such feeds through informed policy actions could enhance returns on transpired water. Additionally, other water harvesting and conservation methods are also essential to sustain more productive crop–livestock systems within water-stressed regions like Burkina Faso.
Magnetic treatment of irrigation water and its effect on French bean (Phaseolus vulgaris)
Authors: Kishore Gottam , Singh Ranjay Kumar , Saxena C. K. , Al-Ansari Nadhir , Vishwakarma Dinesh Kumar , Heddam Salim 
Published: October 2023

Abstract

Magnetic water treatment (magnetic treatment device (MTD)) has long been a contentious procedure for domestic water treatment. This study examines the pros and cons of using different water types with and without a magnetic field treatment for growing French bean crop irrigation. The MTD used in this experiment works by ionizing the dissolved solid using a cathode and anode, electrolysing water using a dynamic pulse current at 50 kHz, and energizing the cations using a 7,000 Gauss magnet. The MTD of normal, waste and saline water enhanced the yield by 12.7, 16.9, and 20.07% over their respective control plots. Contrarily, seed protein (22.52 g/100 g), vitamin A (687.09 IU), potassium (212.44 mg/100 g), vitamin K (14.32 mg/100 g), and calcium (39.93 mg/100 g) reached their peak values when French bean plants were irrigated by magnetically treated wastewater. Na concentration in pods was significantly reduced when 3,000 mg/L of magnetically treated saline water was used to irrigate French bean plants. The MTD of irrigation water has also improved N and K desorption from colloidal soil complexes, which significantly helped make these two elements easily available to the plants and promoting better plant growth and yield. Overall, using the MTD, the overall characteristics of French bean were improved.
Review on the Drug Intolerance and Vaccine Development for the
Leishmaniasis
Authors: Kumari Priya , Mamud Afrin , Jha Anupam Nath 
Published: October 2023

Abstract:
Leishmaniasis is one of the Neglected Tropical Diseases (NTDs), a zoonotic disease of
vector-borne nature that is caused by a protozoan parasite Leishmania. This parasite is transmitted
by the vector sandfly into the human via a bite. Visceral leishmaniasis (VL), also called kala-azar,
is the most fatal among the types of leishmaniasis, with high mortality mostly spread in the East
Africa and South Asia regions. WHO report stated that approximately 3.3 million disabilities occur
every year due to the disease along with approximately 50,000 annual deaths. The real matter
of concern is that there is no particular effective medicine/vaccine available against leishmaniasis
to date except a few approved drugs and chemotherapy for the infected patient. The current selection
of small compounds was constrained, and their growing drug resistance had been a major worry.
Additionally, the serious side effects on humans of the available therapy or drugs have made it
essential to discover efficient and low-cost methods to speed up the development of new drugs
against leishmaniasis. Ideally, the vaccine could be a low risk and effective alternative for both
CL and VL and elicit long-lasting immunity against the disease. There are a number of vaccine
candidates at various stages of clinical development and preclinical stage. However, none has successfully
passed all clinical trials. But, the successful development and approval of commercially
available vaccines for dogs against canine leishmaniasis (CanL) provides evidence that it can be
possible for humans in distant future. In the present article, the approaches used for the development
of vaccines for leishmaniasis are discussed and the progress being made is briefly reviewed.
The Value of Applying Machine Learning in Predicting the Time of Symptom Onset in Stroke Patients: Systematic Review and Meta-Analysis
Authors: Feng Jing , Zhang Qizhi , Wu Feng , Peng Jinxiang , Li Ziwei , Chen Zhuang 
Published: October 2023

Background
Machine learning is a potentially effective method for identifying and predicting the time of the onset of stroke. However, the value of applying machine learning in this field remains controversial and debatable.

Objective
We aimed to assess the value of applying machine learning in predicting the time of stroke onset.

Methods
PubMed, Web of Science, Embase, and Cochrane were comprehensively searched. The C index and sensitivity with 95% CI were used as effect sizes. The risk of bias was evaluated using PROBAST (Prediction Model Risk of Bias Assessment Tool), and meta-analysis was conducted using R (version 4.2.0; R Core Team).

Results
Thirteen eligible studies were included in the meta-analysis involving 55 machine learning models with 41 models in the training set and 14 in the validation set. The overall C index was 0.800 (95% CI 0.773-0.826) in the training set and 0.781 (95% CI 0.709-0.852) in the validation set. The sensitivity and specificity were 0.76 (95% CI 0.73-0.80) and 0.79 (95% CI 0.74-0.82) in the training set and 0.81 (95% CI 0.68-0.90) and 0.83 (95% CI 0.73-0.89) in the validation set, respectively. Subgroup analysis revealed that the accuracy of machine learning in predicting the time of stroke onset within 4.5 hours was optimal (training: 0.80, 95% CI 0.77-0.83; validation: 0.79, 95% CI 0.71-0.86).

Conclusions
Machine learning has ideal performance in identifying the time of stroke onset. More reasonable image segmentation and texture extraction methods in radiomics should be used to promote the value of applying machine learning in diverse ethnic backgrounds.

Trial Registration
PROSPERO CRD42022358898; https://www.crd.york.ac.uk/Prospero/display_record.php?RecordID=358898
Formulation and Evaluation of Luliconazole nanosponge gel using Experimental design
Authors: Malothu Narender , Noothi Sadhana , Areti Anka Rao , Pulavarthy Vishnu 
Published: October 2023

Different approaches are being in the practice for the topical application of antifungal drugs, although in a few cases, they have been found less efficient because of their poor cutaneous availability and permeability. Luliconazole (LUL) is one of the antifungal medications that is being used for the treatment of various superficial infections. The poor permeability of LUL is regarded to be a factor for its reduced efficacy. Hence, the current study aimed to develop a nanosponge hydrogel that would improve dermal availability and permeability. A set of nanosponge formulations (L1-L18) were designed with the help of central composite design (Design Expert 13, state ease Inc., Minneapolis, MN, USA). L1-L18 was prepared by using the emulsion solvent evaporation technique. The nanosponges were characterized for drug-excipient compatibility (FTIR, P-XRD, and DSC), and particle size, polydispersibility index, zeta potential, entrapment efficiency (EE), and in vitro drug release; further optimized. The optimized nanosponge formulation (L18) was taken to produce six hydrogels (LF1-LF6) of LUL by varied proportions of the gelling agent. In this process, initially, the gel was constituted with Carbopol 934/ sodium CMC/HPMC. Later, attained hydrogel texture was evaluated for its viscosity, swelling, and membrane permeability, followed by in vitro drug release, and antifungal efficacy study. The nanosponge formulations (L1-L17) had an average particle size of 109±0.45 to 386±0.34 nm, entrapment efficiency of 35.45±0.46- 89.65±0.37 % with 84.67±0.54 -99.65±0.48 % of drug release for 8 h. The formulation L18 was predicted with better responses in particle size, EE, and drug release i.e., 378±0.25 nm, 84.65±0.45%, and of 96.18±0.54%, respectively for 8 h. Out of six formulated nanosponge gels (LF1-LF6), LF2 showed an optimal viscosity (25.69 ±0.45 pa.S), pH (6.87±0.56) and % drug release (80.65 ±0.64%) in 8 h. Drug release was governed by non-fickian diffusion mechanisms and zero-order. Developed nanosponge hydrogel was found as stable and had a high rate of permeation with better retention which can be effective enough in topical applications.
The school environmental project - PRAE as a contribution to the socio-environmental culture of the Megacolegio La Frontera of the Municipality of Villa Del Rosario Norte de Santander.
Authors: Mendoza Rios Johanatan Dario 
Published: October 2023

This research seeks to contribute to the construction of socio-environmental culture from the perspective of the PRAE of the Megacolegio La Frontera de Villa del Rosario through a multimedia strategy that allows to dynamize its integral formation. Research question: Is there Articulation of the PRAE with the PEI of the Educational Institution or is it isolated? What are the potentialities or strengths of the PRAE, in relation to the problems of the locality? Objective: i) To contribute to the construction of socio-environmental culture from social communication in perspective of the School Environmental Project-PRAE of the Megacolegio La Frontera de Villa del Rosario through a multimedia strategy that allows to dynamize its integral formation. Methodology: For this research a qualitative approach was carried out since the objective is to contribute to the construction of socio-environmental culture from social communication in perspective of the PRAE of the Megacolegio La Frontera de Villa del Rosario through a multimedia strategy that allows to dynamize its integral formation. Results: The methodological results expose the realization of the objectives to an affected population, from the socio-cultural spheres in such a way that it allowed to determine the causes, the advances and the scope on the study area. Conclusions: The potentialities and weaknesses of the PRAE are identified, the weaknesses and environmental potentialities leave a positive and negative impact of them not only on natural systems, but also on social systems.