bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors
Authors: Cooper Fay , Souilhol Celine , Haston Scott , Gray Shona , Boswell Katy , Gogolou Antigoni , Frith Thomas J. R. , Stavish Dylan , James Bethany M. , Bose Daniel , Kim Dale Jacqueline , Tsakiridis Anestis 
Published: January 2024

ABSTRACT
The generation of the post-cranial embryonic body relies on the coordinated production of spinal cord neurectoderm and presomitic mesoderm cells from neuromesodermal progenitors (NMPs). This process is orchestrated by pro-neural and pro-mesodermal transcription factors that are co-expressed in NMPs together with Hox genes, which are essential for axial allocation of NMP derivatives. NMPs reside in a posterior growth region, which is marked by the expression of Wnt, FGF and Notch signalling components. Although the importance of Wnt and FGF in influencing the induction and differentiation of NMPs is well established, the precise role of Notch remains unclear. Here, we show that the Wnt/FGF-driven induction of NMPs from human embryonic stem cells (hESCs) relies on Notch signalling. Using hESC-derived NMPs and chick embryo grafting, we demonstrate that Notch directs a pro-mesodermal character at the expense of neural fate. We show that Notch also contributes to activation of HOX gene expression in human NMPs, partly in a non-cell-autonomous manner. Finally, we provide evidence that Notch exerts its effects via the establishment of a negative-feedback loop with FGF signalling.
Characterizing chromosomal instability-driven cancer evolution and cell fitness at a glance
Authors: Tijhuis Andréa E. , Foijer Floris 
Published: January 2024

ABSTRACT
Chromosomal instability (CIN), an increased rate of chromosome segregation errors during mitosis, is a hallmark of cancer cells. CIN leads to karyotype differences between cells and thus large-scale heterogeneity among individual cancer cells; therefore, it plays an important role in cancer evolution. Studying CIN and its consequences is technically challenging, but various technologies have been developed to track karyotype dynamics during tumorigenesis, trace clonal lineages and link genomic changes to cancer phenotypes at single-cell resolution. These methods provide valuable insight not only into the role of CIN in cancer progression, but also into cancer cell fitness. In this Cell Science at a Glance article and the accompanying poster, we discuss the relationship between CIN, cancer cell fitness and evolution, and highlight techniques that can be used to study the relationship between these factors. To that end, we explore methods of assessing cancer cell fitness, particularly for chromosomally unstable cancer.
Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B
Authors: Peterson Ashley , Bennin David , Lasarev Michael , Chini Julia , Beebe David J. , Huttenlocher Anna 
Published: January 2024

ABSTRACT
Neutrophil-directed motility is necessary for host defense, but its dysregulation can also cause collateral tissue damage. Actinopathies are monogenic disorders that affect the actin cytoskeleton and lead to immune dysregulation. Deficiency in ARPC1B, a component of the Arp2/3 complex, results in vascular neutrophilic inflammation; however, the mechanism remains unclear. Here, we generated human induced pluripotent stem cell (iPSC)-derived neutrophils (denoted iNeutrophils) that are deficient in ARPC1B and show impaired migration and a switch from forming pseudopodia to forming elongated filopodia. We show, using a blood vessel on a chip model, that primary human neutrophils have impaired movement across an endothelium deficient in APRC1B. We also show that the combined deficiency of ARPC1B in iNeutrophils and endothelium results in further reduction in neutrophil migration. Taken together, these results suggest that ARPC1B in endothelium is sufficient to drive neutrophil behavior. Furthermore, the findings provide support for using the iPSC system to understand human neutrophil biology and model disease in a genetically tractable system.
The Association Between Intraoperative Compromised Intestinal Integrity and Postoperative Complications in Cancer Patients
Authors: Hendriks Sharon , Huisman Monique G. , Stokmans Suzanne C. , Plas Matthijs , van der Wal-Huisman Hanneke , van Munster Barbara C. , Absalom Anthony R. , Nieuwenhuijs-Moeke Gertrude J. , de Bock Geertruida H. , van Leeuwen Barbara L. , de Haan Jacco J. 
Published: January 2024

Abstract
Background
Because of perioperative splanchnic hypoperfusion, the gut wall becomes more permeable for intraluminal microbes to enter the splanchnic circulation, possibly contributing to development of complications. Hypoperfusion-related injured enterocytes release intestinal fatty acid binding protein (I-FABP) into plasma, which is used as proxy of intestinal integrity. This study investigates the occurrence of intestinal integrity loss during oncologic surgery, measured by I-FABP change. Secondary the relationship between compromised intestinal integrity, and related variables and complications were studied.

Methods
Patients undergoing oncologic surgery from prospective cohort studies were included. Urine I-FABP samples were collected preoperatively (T0) and at wound closure (T1), and in a subgroup on Day 1 (D1) and Day 2 (D2) postoperatively. I-FABP dynamics were investigated and logistic regression analyses were performed to study the association between I-FABP levels and patient-related, surgical variables and complications.

Results
A total of 297 patients were included with median age of 70 years. Median I-FABP value increased from 80.0 pg/mL at T0 (interquartile range [IQR] 38.0–142.0) to 115 pg/mL at T1 (IQR 48.0–198.0) (p < 0.05). Age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02–1.08) and anesthesia time (OR 1.13, 95% CI 1.02–1.25) were related to stronger I-FABP increase. When comparing I-FABP change in patients experiencing any complications versus no complications, relative I-FABP change at T1 was 145% of T0 (IQR 86–260) versus 113% (IQR 44–184) respectively (p < 0.05).

Conclusions
A significant change in I-FABP levels was seen perioperatively indicating compromised intestinal integrity. Age and anesthesia time were related to higher I-FABP increase. In patients experiencing postoperative complications, a higher I-FABP increase was found.
Proceso linfoproliferativo tipo T en lengua: a propósito de un caso
Authors: Almeida-Ayerve Cristina Nicole , Fernández-Nava María José , Marcos-Alonso Susana , Ferreira-Cendón Sofía , Coronel-Touma Guillermo Salib , Blanco-Perez Pedro 
Published: January 2024

Introducción: Los síndromes linfoproliferativos (SLP) de estipe T, constituyen el 15% de todos los linfomas No Hodking. La localización de los linfomas extra nodales más frecuentes se encuentra en el área gastrointestinal, seguida del área cérvico-facial (34%). En la cavidad oral se localizan por lo general en el anillo de Waldeyer (5-10%), siendo los linfomas de lengua los más infrecuentes, representando el 3% de todos los linfomas del área cérvico-facial. Dentro de las formas cutáneas, la enfermedad linfoproliferativa CD30+, constituye el segundo tipo más frecuente de linfoma cutáneo tipo T.
Descripción del caso clínico: Paciente mujer de 78 años derivada de atención primaria por persistencia de lesión en el dorso de hemilengua derecha además de glosodinia y odinofagia. En la exploración física se describió lesión nodular en medallón grisácea que no sobrepasaba la línea media, indurada y dolorosa a la palpación. Bajo anestesia local, se realizó una toma de biopsia, la misma que describió proceso linfoproliferativo T-CD30+ y con resultado del ADN de la muestra enviada a biología molecular con presencia de reordenamiento clonal del receptor de células T. Con estos resultados, se solicitó prueba de imagen (PET-TAC) de cuerpo entero donde no se evidenciaron focos sugerentes de infiltración linfoproliferativa metabólicamente activa. Con estos resultados se derivó a la paciente al servicio de Hematología para su valoración y posterior tratamiento pertinente.
Conclusiones: Los linfomas de localización extranodal en lengua al ser muy infrecuentes representan un reto diagnóstico, por lo que es importante tenerlos en cuenta a la hora de su valoración además de una adecuada correlación clínico-patológica apoyados siempre en los exámenes complementarios de imagen y por supuesto histológicos y de biología molecular.
The Emergence of Marx’s Concept of Subsumption
Authors: Giladi Tal Meir 
Published: January 2024

Abstract
In Marx’s posthumously published manuscripts from 1857–1863, we find a systematic exposition of his concept of subsumption. Though much has been written about it, significant interpretative gaps persist. In this article, I begin filling these gaps by examining the emergence of Marx’s concept of subsumption. I will argue that in the Grundrisse Marx brings together distinct but complementary elements from Hegel’s theories of judgment and teleology to coin two new and well delineated concepts of subsumption that prefigure his later concepts of formal and real subsumption. These two concepts may be defined as: (a) the process of acquiring the social relational property of being a means to an end; (b) the process by which changes in non-relational properties occur in something due to this acquisition – and occur to better suit said end.
Märchen in der Oper – am Beispiel des Opernhauses Zürich
Authors: Kosacka Małgorzata 
Published: January 2024

Zusammenfassung
Der Aufsatz untersucht die Entwicklung der Märchenoper im Opernhaus Zürich. Im Einzelnen werden zwei Opernlibretti ausgewertet, denen Volksmärchen zugrunde liegen: Das verzauberte Schwein und Hänsel und Gretel. Hinzu kommt die kursorische Betrachtung von neun Opernlibretti, denen andere Märchen beziehungsweise märchenhafte Stoffe zugrunde liegen oder die als Operntexte für Kinder erdichtet wurden und die seit 2010 am Opernhaus Zürich ihre Uraufführung feierten. Es geht um die Frage, nach welchen poetischen und dramaturgischen Prinzipien die Märchenoper mit Volksmärchen verfährt.
Ddakjibon: Ein populärer Lesestoff in der koreanischen Moderne
Authors: Sung-hwa Kim 
Published: January 2024

Zusammenfassung
Das Ddakjibon (딱지본) bezeichnet eine Art populären Lesestoff mit bunten Buchumschlägen in der koreanischen Moderne, der etwa 1900 mit der Einführung der modernen Drucktechnik aufkam. Ddakjibon waren billige, dünne Hefte oder Bücher mit Druckpapier niedriger Qualität. Sie wurden bis in die 1970er Jahre durch kleine Händler und Kolporteuren auf dem Markt bzw. auf der Straße verkauft. Ihre Rezeption erfolgte sowohl durch berufliche Vorleser als auch durch private Lektüre. An diesen unterschiedlichen Lektüreformen soll die Herausbildung des modernen Lesepublikums in Korea und die Übergangsphase von einer semi-oralen bzw. semi-literalen zu einer schriftbasierten Kultur herausgearbeitet werden.
Sublinearly Morse boundary of CAT(0) admissible groups
Authors: Nguyen Hoang Thanh , Qing Yulan 
Published: January 2024

AbstractWe show that if 𝐺 is an admissible group acting geometrically on aCAT⁡(0)\operatorname{CAT}(0)space 𝑋, then 𝐺 is a hierarchically hyperbolic space and its 𝜅-Morse boundary(∂κG,ν)(\partial_{\kappa}G,\nu)is a model for the Poisson boundary of(G,μ)(G,\mu), where 𝜈 is the hitting measure associated to the random walk driven by 𝜇.
(Im)politeness as object, (im)politeness as perspective
Authors: Haugh Michael 
Published: January 2024

Abstract
The first-second order distinction has dominated theoretical discussions about (im)politeness for the past two decades. However, while there has been a lot of emphasis placed on different perspectives on (im)politeness in the field, what constitutes our object of understanding(s) arguably remains somewhat more elusive. In this paper, I suggest that one of the reasons for this is that we have inadvertently conflated (im)politeness-as-perspective (an epistemological issue) with (im)politeness-as-object (an ontological issue), and have largely ignored the latter in ongoing debates about the first-second order distinction. Building on observations about mundane interactions between co-participants who behave in ways we might not typically associate with politeness, I first propose that (im)politeness-as-object encompasses a complex, multi-layered set of first, second and third order evaluations that are reflexively interrelated but nevertheless ontologically distinct. I then suggest that the inherent complexity of (im)politeness-as-object calls for a more nuanced account of (im)politeness-as-perspective in which researchers necessarily draw on different first-order (commonsense, emic, user, folk theoretic) and second-order (academic, etic, observer, scientific theoretic) understandings to varying degrees. I conclude that the multidimensional, prismatic model of (im)politeness that emerges reflects the complex and multifaceted nature of (im)politeness itself.
The Influence of Heritage Image, Destination Image, and Experiential Quality on Behavioural Intentions of Foreign Tourists
Authors: Junarta Harbyanto , Nuryakin Nuryakin , Fatmawati Indah 
Published: January 2024

This research examines heritage image model influence, destination image, experiential quality in influencing tourist behavioral intention in Mandalika Kuta beach Lombok. Mandalika Kuta beaches Lombok as the object, while the subject is foreign tourists. This research used the Purposive sampling method and 133 respondents as the sample. The tool analysis is using Structural Equation modeling/AMOS. The heritage image and destination image give positive influences to the tourist’s experiential quality; the experiential quality gives positive impacts to the tourist’s revisit intentions. The limitation of this study is that the time to conduct this study is limited, only one month. In addition, the indicators used in this study are limited. This research has a significant practical contribution; Some objectives still focus on providing product-oriented marketing and management practices.
Analysis of the Effect of Non-Performing Loan, Return on Assets, Return on Equity and Size on Banking Liquidity Risk (Case Study on Conventional Banks Registered in IDX period 2016 – 2020)
Authors: Widyarti Endang Tri , Widyakto Adhi , Suhardjo Yohanes 
Published: January 2024

In the economy of a country, banking has a big part to do. Banking plays an important role in lending in public and private areas. The function of banking as an intermediary, which the bank is useful as an intermediary between the parties who are sufficient to those in need. This research is focused on areas that have an effect on liquidity risk in banks. The purpose of this research is nothing but to analyze the securities of NPL, ROA, ROE and Size to liquidity risk in banks listing in IDX for the period 2016-2020. The samples used in the research of all banks, both state-owned (SOE) and National Private Banks in Indonesia are recognized in BI from 2016 to 2020. From the criteria obtained by 40 banks, the method used is purposive sampling. The method of analysis used in this research is linear regression, which is tested through classical assumptions with normality, multicollinearity, autocorrelation and heteroscedasticity. The results showed that roa and ROE variables have a good and significant effect on liquidity risk. Medium variable NPL and Size have an adverse and insignificant effect on liquidity risk.
Genetics of gambling disorder and related phenotypes: The potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes
Authors: Warrier Varun , Chamberlain Samuel R , Thomas Shane A. , Bowden-Jones Henrietta 
Published: January 2024

AbstractGambling Disorder (GD) is an impactful behavioural addiction for which there appear to be underpinning genetic contributors. Twin studies show significant GD heritability results and intergenerational transmission show high rates of transmission. Recent developments in polygenic and multifactorial risk prediction modelling provide promising opportunities to enable early identification and intervention for at risk individuals. People with GD often have significant delays in diagnosis and subsequent help-seeking that can compromise their recovery. In this paper we advocate for more research into the utility of polygenic and multifactorial risk modelling in GD research and treatment programs and rigorous evaluation of its costs and benefits.
Mental health professionals' use of the ICD-11 classification of impulse control disorders and behavioral addictions: An international field study
Authors: Fuss Johannes , Keeley Jared W. , Stein Dan J. , Rebello Tahilia J. , García José Ángel , Briken Peer , Robles Rebeca , Matsumoto Chihiro , Abé Christoph , Billieux Joël , Grant Jon E. , Kraus Shane W. , Lochner Christine , Potenza Marc N. , Reed Geoffrey M. 
Published: January 2024

AbstractBackground and aimsThe ICD-11 chapter on mental, behavioral and neurodevelopmental disorders contains new controversial diagnoses including compulsive sexual behavior disorder (CSBD), intermittent explosive disorder (IED) and gaming disorder. Using a vignette-based methodology, this field study examined the ability of mental health professionals (MHPs) to apply the new ICD-11 diagnostic requirements for impulse control disorders, which include CSBD and IED, and disorders due to addictive behaviors, which include gaming disorder, compared to the previous ICD-10 guidelines.MethodsAcross eleven comparisons, members of the WHO's Global Clinical Practice Network (N = 1,090) evaluated standardized case descriptions that were designed to test key differences between the diagnostic guidelines of ICD-11 and ICD-10.ResultsThe ICD-11 outperformed the ICD-10 in the accuracy of diagnosing impulse control disorders and behavioral addictions in most comparisons, while the ICD-10 was not superior in any. The superiority of the ICD-11 was particularly clear where new diagnoses had been added to the classification system or major revisions had been made. However, the ICD-11 outperformed the ICD-10 only in a minority of comparisons in which mental health professionals were asked to evaluate cases with non-pathological high involvement in rewarding behaviors.Discussion and ConclusionsOverall, the present study indicates that the ICD-11 diagnostic requirements represent an improvement over the ICD-10 guidelines. However, additional efforts, such as training programs for MHPs and possible refinements of diagnostic guidance, are needed to avoid over-diagnosis of people who are highly engaged in a repetitive and rewarding behavior but below the threshold for a disorder.
MTRR gene rs1801394 polymorphism is associated with neonatal birth weight in pregnant women with fetal growth retardation
Authors: Reshetnikova Yu. N. , Ponomarenko I. V. , Churnosov V. М. , Ponomarenko M. S. , Churnosov M. I. , Reshetnikov E. A. 
Published: January 2024

Aim: to assess associations between folate cycle gene polymorphism and neonatal birth weight in pregnant women with fetal growth retardation (FGR) and related functional effects in population of the Central Black Earth Region.Materials and Methods. 98 cases of women with FGR were enrolled to a retrospective molecular and genetic screening to assess prevalence 5 SNPs (single nucleotide polymorphisms) in genes involved in folic acid cycle and methionine metabolism (rs699517 TYMS, rs2790 TYMS, rs1979277 SHMT1, rs1805087 MTR, rs1801394 MTRR).Results. It was found out that allele A of the rs1801394 MTRR was associated with a lower neonatal birth weight (recessive model: β = –0.34 ± 0.13; p = 0.009). This polymorphic locus exerts crucial functional effects by determining the amino acid substitution in methionine synthase reductase (Ile22Met) localized in the region of modified histones, which mark enhancers and promoters in ectoderm, endoderm and mesoderm cell cultures, primary osteoblast cells, brain, fat nuclei, skeletal muscles, etc. In addition, rs1801394 MTRR is found DNA sites (motifs) responsible for sensitivity to transcription factors STAT and TBX5 being also related to MTRR gene mRNA expression level in subcutaneous and visceral adipose tissue, thyroid gland, fibroblast cell culture as well as various brain regions.Conclusion. Thus, the allele A of the rs1801394 polymorphism in MTRR gene is a risk factor for a lower neonatal birth weight.
Resilience in vulnerable university groups: An analysis of social work intervention strategies from the perspective of social inclusion
Authors: Mendoza Velazco D. J. , Alava Barreiro L. M. , Moreira Chica T. K. , Alcivar Medranda E. M. , Romero Chávez S. A. 
Published: January 2024

Introduction. Resilience refers to the ability of individuals, groups or communities to adapt and recover in the face of adverse or stressful situations, such as violence, poverty, natural disasters or disease. Aim. The present research aims to analyse the impact of social work intervention in strengthening resilience in vulnerable groups served by the Faculty of Humanistic and Social Sciences of the Technical University of Manabí during the 2023-A academic period, to identify the pedagogical intervention of social work in vulnerable groups, and to evaluate the effectiveness of the intervention strategies implemented by social work professionals. Methodology and research methods. The quantitative paradigm was applied. The design corresponds to a non-experimental study. The population was 259 students of Social Work. The sample consisted of 70 students belonging to vulnerable groups. A questionnaire with 15 items was applied. Multiple regression analysis and ANOVA analysis were carried out. Results. Among the results, the pedagogical intervention strategies applied by the social work professionals were effective. There is a positive impact on strengthening resilience in vulnerable groups, as well as on socio-economic and cultural factors. Social work pedagogical intervention strategies as well as socio-economic and cultural factors are important in strengthening resilience in vulnerable groups. Scientific novelty. The scientific novelty of this study is that building resilience through inclusion stands out as a pedagogical component in social work and as a pillar that strengthens social work. Practical significance. It is important to take socio-economic and cultural factors into account when designing and implementing these pedagogical strategies, as they can influence their effectiveness. It is also important to continue research on the factors that influence the development of resilience in vulnerable groups in order to design and implement more effective and sustainable educational intervention strategies.
La protesta entre representación visual y representación pol´ítica
Authors: León Cannock Alejandro 
Published: January 2024

El escritor Tzvetan Todorov afirma que, debido a nuestro carácter temporal, los animales humanos hemos desarrollado la memoria: esta facultad nos permite estabilizarnos existencialmente conectando lo vivido en el presente con lo vivido en el pasado, instaurando así líneas de continuidad entre momentos heterogéneos.