bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work-related experiences and unmet needs of patients with a malignant glioma and relevant professionals: the BrainWork study
Authors: Zegers Amber Daniëlle , Coenen Pieter , Heeren Amy , Takke Nadia , Ardon Hilko , Compter Annette , Dona Desiree , Kouwenhoven Mathilde , Schagen Sanne B. , de Vos Filip , Duijts Saskia F. A. 
Published: October 2023

Abstract

Purpose
Many patients with a malignant (i.e., grade II-IV) glioma are of working age, yet they are rarely included in “cancer and work” studies. Here, we explored (1) the work-related experiences and unmet needs of patients with a malignant glioma and (2) the experiences and needs of relevant healthcare and occupational (health) professionals (“professionals”) in providing work-related support to this patient group.

Methods
Individual semi-structured interviews were held with patients with a malignant glioma who were of working age and had an employment contract at diagnosis, and relevant professionals. Interviews were transcribed verbatim and analysed thematically.

Results
Patients (n = 22) were on average 46 ± 13 years of age (64% male) and diagnosed with a grade II (n = 12), III (n = 4), or IV glioma (n = 6). Professionals (n = 16) had on average 15 ± 9 years of relevant work experience with the patient group. Four themes emerged from the data: (1) having a malignant glioma: experienced consequences on work ability, (2) communicating about the consequences of a malignant glioma at work, (3) distilling the right approach: generic or tailored work-related support, and (4) accessibility of work-related support.

Conclusions
Glioma-specific consequences on patients’ work ability necessitate better communication between, and tailored guidance for, patients, relevant professionals, and the workplace. Suggestions for improvement, e.g., the periodic use of comprehensive neuropsychological assessments, are provided in the article.

Implications for cancer survivors
Patients with a malignant glioma would benefit from tailored and proactive outreach about work-related issues bv relevant professionals.
Sirtuins as Potential Targets for Neuroprotection: Mechanisms of Early Brain Injury Induced by Subarachnoid Hemorrhage
Authors: Lei Kunqian , Wu Rui , Wang Jin , Lei Xianze , Zhou Erxiong , Fan Ruiming , Gong Lei 
Published: October 2023

AbstractSubarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant global mortality and morbidity rates. Despite advancements in pharmacological and surgical approaches, the quality of life for SAH survivors has not shown substantial improvement. Traditionally, vasospasm has been considered a primary contributor to death and disability following SAH, but anti-vasospastic therapies have not demonstrated significant benefits for SAH patients' prognosis. Emerging studies suggest that early brain injury (EBI) may play a crucial role in influencing SAH prognosis. Sirtuins (SIRTs), a group of NAD + -dependent deacylases comprising seven mammalian family members (SIRT1 to SIRT7), have been found to be involved in neural tissue development, plasticity, and aging. They also exhibit vital functions in various central nervous system (CNS) processes, including cognition, pain perception, mood, behavior, sleep, and circadian rhythms. Extensive research has uncovered the multifaceted roles of SIRTs in CNS disorders, offering insights into potential markers for pathological processes and promising therapeutic targets (such as SIRT1 activators and SIRT2 inhibitors). In this article, we provide an overview of recent research progress on the application of SIRTs in subarachnoid hemorrhage and explore their underlying mechanisms of action.
The upper cretaceous carbonate sediments of the Ras Budran Field, Gulf of Suez, Egypt: stacking patterns and depositional controls
Authors: Salman Abdelhamid M. 
Published: October 2023

AbstractThe present study interprets the carbonate stacking patterns and their depositional controls in the Upper Cretaceous strata of the Ras Budran Field in the Gulf of Suez, Egypt, on the basis of integrated well logging and a geological report provided. A set of well logs was run for two wells (RB-A2 and RB-B2), comprising gamma ray, resistivity, density, neutron, sonic, and photoelectric factor. Composite logs and geological reports were also used to help deduce the lithological and biological description of the stratigraphic units under investigation. The stacking patterns of the carbonate rocks yielded three types of electro-facies. The first facies covers the lower part of the Brown Limestone (early Campanian) and reflects a cylindrical (aggrading) stacking pattern. This facies indicates keep-up carbonate deposition in a heterogeneous facies accumulated in shallow water. The second facies covers the upper part of the Brown Limestone (late Campanian) and displays a funnel (prograding) stacking pattern. This facies indicates the depositional setting of a shallow shoreline. The third facies covers the Sudr Chalk (Maastrichtian), for which a serrated stacking pattern indicates an aggradational environment. This pattern indicates a marine depositional setting both distal and deep. Therefore, the formation and evolution of the cyclical stacking pattern of the carbonate rocks reflects variations in accommodation potential that determines the environmental changes. The evolution of these deposits is mainly attributed to a combination of eustatic sea-level fluctuations and tectonic episodes within the basin.
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination
Authors: Shi Si , Zhang Qicheng , Zhang Kaiwen , Chen Wenhui , Xie Haijing , Pan Si , Xue Ziyi , You Bo , Zhao Jianmei , You Yiwen 
Published: October 2023

Abstract
Purpose
Nasopharyngeal carcinoma (NPC) has characteristics of high invasion and early metastasis. Most NPC patients present with locoregionally advanced illness when first diagnosed. Therefore, it is urgent to discover NPC biomarkers. Fibroblast growth Factor 19 (FGF19) plays a role in various physiological or pathological processes, including cancer. In this research, we discovered the importance of FGF19 in NPC, and clarified its role in tumour angiogenesis.

Methods
Western blotting, immunohistochemistry and ELISA were used to investigate FGF19 expression in NPC. Then we took CCK8, colony formation, Transwell and wound healing assays to identify the influence of FGF19 on NPC malignant behaviours. The proliferative and metastatic capacity of FGF19 were evaluated in nude mice and zebrafish. The role of FGF19 in angiogenesis was investigated by tube formation and Matrigel plug angiogenesis assays. We then evaluated the variation in Annexin A2(ANXA2) levels with the treatment of FGF19. Lastly, co-immunoprecipitation and ubiquitination assays were performed to identify the mechanisms involved.

Results
FGF19 levels were elevated in tissues and serum of NPC patients and were associated with poor clinical stages. High expression of FGF19 promoted NPC malignant behaviours. In particular, FGF19 expression was correlated with microvessel density in tissues and NPC-derived FGF19 could accelerate angiogenesis in vitro and in vivo. Mechanistically, FGF19 influenced ANXA2 expression to promote angiogenesis. Moreover, tripartite motif-containing 21(TRIM21) interacted with ANXA2 and was responsible for ANXA2 ubiquitination.

Conclusion
FGF19 promoted NPC angiogenesis by inhibiting TRIM21-mediated ANXA2 ubiquitination. It may serve as a noninvasive biomarker for NPC and provides new insights for therapy.
Differences in Symptom Burden in Primary Brain Tumor Patients Based on Sex, Race, and Ethnicity: a Single-Center Retrospective Study
Authors: Brady Kendall , Cohen Adam L. 
Published: October 2023

Abstract
Background
Symptom burden affects quality of life and prognosis in primary brain tumor (PBT) patients. Knowing whether symptom burden varies based on sex, race, or ethnicity may affect the interpretation of the relationship between symptoms and survival may reveal issues with applying the tools to measure symptom burden to different groups and may identify inequities in symptom management that need to be addressed at a system level. To determine whether symptoms in PBT patients vary across demographic groups, we conducted a retrospective chart review of symptom burden collected as part of routine care in a diverse population.

Methods
Patient demographics and scores on the MD Anderson Symptom Inventory-Brain Tumor (MDASI-BT) module were extracted from the electronic medical record for patients seen in the Inova Neuro-oncology Clinic between March 2021 and June 2022. MDASI-BT scores were compared based on side of tumor, sex, race, and ethnicity for the entire population and for the subset with gliomas.

Results
We included 125 people, of whom 85 had gliomas. For both the entire group and the subgroup with gliomas, about 40% were female and about 40% were non-White race. No differences in symptom burden were seen between males and females. Pain and numbness/tingling symptom burden were higher in both the entire population and the glioma subgroup for people of Hispanic/Latino/Spanish ethnicity and for people of races other than White or Middle Eastern self-identification.

Conclusions
Pain, weakness, and numbness/tingling varied significantly across racial and ethnic groups. Further research is needed to validate this finding in other populations and determine its cause.
Atypical Placental Site Nodules within the Diverticulum of the Uterine Incision, a Rare Gestational Trophoblastic Disease Misdiagnosed as Intrauterine Residue: A Case Report
Authors: Li Xin , Li Yanli , Shi Xiuting , Cheng Shiyu , Meng Tingzhu , Gao Han , Shi Jie 
Published: October 2023

AbstractAtypical placental site nodule (APSN) is a rare benign gestational trophoblastic disease (GTD). It is a tumor-like transformation that has a certain probability of developing into a placental site trophoblastic tumor (PSTT) or epithelioid trophoblastic tumor (ETT). Because of its atypical clinical presentation, it is difficult to diagnose and susceptible to misdiagnosis highly, thus delaying the patient’s condition. We report a scarce case of atypical nodules at the placental site of the uterine incision diverticulum in a 35-year-old female, who was irregular vaginal bleeding after a cesarean Sect. 2 years. She was diagnosed by several local hospitals with intrauterine residue and was given a variety of Traditional Chinese Medicine (TCM) orally, but the symptoms of irregular vaginal bleeding have not been alleviated. After being transferred to several hospitals, she went to Hubei Maternal and Child Health Hospital for treatment. Under the condition of excluding the second pregnancy, she underwent hysteroscopic resection of lesions and laparoscopic repair of uterine incision diverticulum. The pathological diagnosis after the operation suggested that the focus at the uterine incision was an atypical placental nodule that invaded the myometrium of the uterus. The operation completely removed the focus, and then the patient was followed up every 3 months in the first postoperative year, then every 6 months up to 3 years, and then annually thereafter up to 5 years, and then maybe every 2 years thereafter. The patient’s condition was quickly controlled, and the prognosis was good.
An overview of polarized neutron instruments and techniques in Asia Pacific
Authors: Jiang Chenyang 
Published: October 2023

AbstractPolarized neutron scattering is an indispensable tool for exploring a vast range of scientific phenomena. With its dynamic scientific community and significant governmental support as well as the rapid economic growth, the Asia–Pacific region has become a key player in the worldwide neutron scattering arena. From traditional research reactors to cutting-edge spallation neutron sources, this region is home to a myriad of advanced instruments offering a wide range of polarized neutron capabilities. This review aims to provide a comprehensive overview of the development and current status of polarized neutron instruments and techniques in the Asia–Pacific region, emphasizing the important role of the Asia–Pacific region in shaping the landscape of global polarized neutron scattering development.
The Uncover Process for Random Labeled Trees
Authors: Hackl Benjamin , Panholzer Alois , Wagner Stephan 
Published: October 2023

AbstractWe consider the process of uncovering the vertices of a random labeled tree according to their labels. First, a labeled tree with n vertices is generated uniformly at random. Thereafter, the vertices are uncovered one by one, in order of their labels. With each new vertex, all edges to previously uncovered vertices are uncovered as well. In this way, one obtains a growing sequence of forests. Three particular aspects of this process are studied in this work: first the number of edges, which we prove to converge to a stochastic process akin to a Brownian bridge after appropriate rescaling; second, the connected component of a fixed vertex, for which different phases are identified and limiting distributions determined in each phase; and lastly, the largest connected component, for which we also observe a phase transition.
Exploring sociodemographic factors of problematic internet use: a cross-national study of North Macedonia and Poland
Authors: Domalewska Dorota , Jovanoski Aleksandar , Nenovski Blagoj , Sharlamanov Kire , Żakowska Marzena 
Published: October 2023

AbstractThis paper investigates the correlation between problematic internet use (PIU) and sociodemographic factors, with a specific emphasis on culture, gender, and age. Employing a quantitative, cross-national survey design, data was collected from a total of 780 respondents from North Macedonia and Poland. The study did not find relationship between demographic factors, such as age and gender, and PIU. However, disparities emerged upon examination of cross-national differences. Respondents from North Macedonia exhibited a greater susceptibility to PIU when compared to those from Poland. These national differences manifested across multiple aspects of PIU, including decreased enjoyment of offline activities, diminished real-life relationships, and weakened self-control. The findings emphasize the importance of considering cultural context when studying internet usage patterns and potential addiction. As social media and the internet have become a regular social activity, prevention campaigns should be based on social norms and harm-reduction strategies directed towards social groups rather than individuals. This approach acknowledges the collective nature of the problem and seeks to address the root causes of problematic internet use.
Exploring team dynamics during the development of a multi-institutional cross-disciplinary translational team: Implications for potential best practices
Authors: Kotarba Joseph A. , Molldrem Stephen , Smith Elise , Spratt Heidi , Bhavnani Suresh K. , Farroni Jeffrey S. , Wooten Kevin 
Published: October 2023

Abstract

Introduction:
A recent literature review revealed no studies that explored teams that used an explicit theoretical framework for multiteam systems in academic settings, such as the increasingly important multi-institutional cross-disciplinary translational team (MCTT) form. We conducted an exploratory 30-interview grounded theory study over two rounds to analyze participants’ experiences from three universities who assembled an MCTT in order to pursue a complex grant proposal related to research on post-acute sequelae of COVID-19, also called “long COVID.” This article considers activities beginning with preliminary discussions among principal investigators through grant writing and submission, and completion of reviews by the National Center for Advancing Translational Sciences, which resulted in the proposal not being scored.

Methods:
There were two stages to this interview study with MCTT members: pre-submission, and post-decision. Round one focused on the process of developing structures to collaborate on proposal writing and assembly, whereas round two focused on evaluation of the complete process. A total of 15 participants agreed to be interviewed in each round.

Findings:
The first round of interviews was conducted prior to submission and explored issues during proposal writing, including (1) importance of the topic; (2) meaning and perception of “team” within the MCTT context; and (3) leadership at different levels of the team. The second round explored best practices-related issues including (1) leadership and design; (2) specific proposal assembly tasks; (3) communication; and (4) critical events.

Conclusion:
We conclude with suggestions for developing best practices for assembling MCTTs involving multi-institutional teams.
The impact of modeling decisions in statistical profiling
Authors: Bach Ruben L. , Kern Christoph , Mautner Hannah , Kreuter Frauke 
Published: October 2023

Abstract
Statistical profiling of job seekers is an attractive option to guide the activities of public employment services. Many hope that algorithms will improve both efficiency and effectiveness of employment services’ activities that are so far often based on human judgment. Against this backdrop, we evaluate regression and machine-learning models for predicting job-seekers’ risk of becoming long-term unemployed using German administrative labor market data. While our models achieve competitive predictive performance, we show that training an accurate prediction model is just one element in a series of design and modeling decisions, each having notable effects that span beyond predictive accuracy. We observe considerable variation in the cases flagged as high risk across models, highlighting the need for systematic evaluation and transparency of the full prediction pipeline if statistical profiling techniques are to be implemented by employment agencies.
The Effect of the COVID-19 Pandemic on Environmental Health (Two Sides of the Same Coin): A Systematic Review
Authors: Farrokhi Mehrdad , Khankeh Hamidreza , Saatchi Mohammad , Hadinejad Zoya , Ahmadi-Mazhin Sadegh , Mohsenzadeh Yazdan , Mehraein Nazdik Zahra , Shojafard Javad , Pourvakhshoori Negar , Ahmadi Shokoufeh 
Published: October 2023

Abstract

Background:
The outbreak of the COVID-19 pandemic in late 2019 has led to many changes such as reduced human activities and effects on the environment. There is no big picture of the effects of pandemics on the environment using related evidence.

Objectives:
This study was conducted to investigate the effect of the COVID-19 pandemic on environmental health.

Methods:
A systematic search of English language studies was performed in major electronic databases; Web of Science, PubMed, Scopus, and Google scholar web search engine from December 2019 to February 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard guidelines were used to follow up the review process. finally 58 articles entered the review procedure.

Results:
The results of indicate a significant reduction of air pollutants and improved air quality. It improved the water quality of some rivers, canals, and seas during the lockdown of the COVID-19 pandemic. The effects of this disease on the environment cannot be fully described yet.

Conclusion:
In the short term, the amount of air, water, and coastal pollution has been reduced. few studies have examined the effects of pandemics on the environment in the long run, which paves the way for more researches.
Caring for Delivery: Healthcare Professionals’ Ethical Conflicts in Surrogate Pregnancy
Authors: Triviño-Caballero Rosana 
Published: October 2023

AbstractFrom the beginning of the practice of surrogate pregnancy, ethical approaches to it have included several dimensions. Central issues such as surrogates’ genuine autonomy, the risk of exploitation of people in vulnerable situations, or the legitimacy of the commercialization of the body have kept this debate alive for more than three decades. Among all the conflicts, those related to healthcare professionals involved in the surrogacy process have been less frequently addressed. Which patient(s) should they protect? Whose interests should they preserve, the surrogate mother's or the intended parents’? Are there differences in healthcare provision betweenregularpregnant women and those who are going to relinquish their babies? Is adequate compliance with the ethical standards of the caregiver–patient relationship possible? In this article, I will address these questions to identify interests and practices at stake in the healthcare context, where an important part of the surrogacy process occurs.
Forms of National and European Identity: A Research Note Reviewing Literature of Cross-National Studies
Authors: König Philipp 
Published: October 2023

AbstractIn the past decades, numerous publications have been addressing questions of national and European Identity on the micro level. Only few shed light on the contents that constitute these identities in the minds of Europeans. As different meanings of national and European identity are connected to different consequences such as hostile attitudes toward immigrants or Euroskepticism, reviewing attempts to measure these contents in existing cross-national surveys seems to be promising. This research note summarizes relevant literature on whether and which different forms of national and European identity have been found empirically, which specific contents constitute them, and which determinants and consequences of them are relevant. By comparing articles relying on cross-national survey data since 1995, it will be shown that the field of forms of national and European identity involves different operationalizations and numerous methodological concerns. This leads to considerations for further research in the field.
RIVERSAND: A NEW TOOL FOR EFFICIENT COMPUTATION OF CATCHMENTWIDE EROSION RATES
Authors: Stübner Konstanze , Balco Greg , Schmeisser Nils 
Published: October 2023

ABSTRACTIn-situ cosmogenic 10Be (and 26Al) concentrations in alluvial sediments provide a spatially averaged signal of the erosion rate of the catchment area. Catchmentwide erosion rates reflect the production rate of the entire basin, and their calculation requires knowledge of the complete production rate model. Available calculators determine production rates on a pixel-based approach and achieve computational efficiency by relying on a scaling method that ignores geomagnetic field strength variations. Here we introduce a new python-based tool that determines erosion rates based on the hypsometry of the catchment. The method relies on the fact that production rates are much more sensitive to changes in elevation than latitude. Our tool has two main advantages: (1) computation time is short (<30 seconds) and independent of the scaling method; there is no need to neglect magnetic field variations, and (2) because production rate scaling is performed by a widely used online calculator, the results are fully comparable to exposure ages or point-based erosion rates determined with the same calculator; future updates to production rate scaling are immediately effective for catchmentwide erosion rate calculation. We demonstrate in two case studies that (1) for similar scaling methods, our calculator reproduces pixel-based results within a few percent, and (2) erosion rates determined with different scaling methods may differ by >20%, differences can vary systematically with erosion rate, and using a time-constant scaling method may result in a bias in the interpretation of catchmentwide erosion rates.