bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of web‐based guided self‐help cognitive behavioral therapy‐enhanced for binge‐eating disorder: An implementation study
Authors: Melisse Bernou , van den Berg Elske , de Beurs Edwin 
Published: October 2023

AbstractIntroductionWeb‐based guided self‐help cognitive behavioral therapy‐enhanced (CBT‐E) is a 12‐weeks, 12‐sessions, digitalized version of part II of the self‐help book Overcoming Binge Eating. This intervention is effective when offered under controlled circumstances in a randomized‐controlled‐trial. It is unknown how patients with binge‐eating disorder (BED) respond to this intervention when offered in real‐world clinical‐settings. The aim of this study is to examine post‐intervention effectiveness of guided self‐help CBT‐E for BED in real‐world settings.MethodThe present study used a cohort‐design examining the effectiveness of web‐based guided self‐help CBT‐E according to an intention‐to‐treat (ITT) analysis. BED patients (n = 278) were assessed pre‐ and post‐intervention. The primary outcome was reduction in binge‐eating episodes. Other outcomes were full‐recovery (EDE‐Q score <2.77 and abstinence from binge‐eating episodes), impaired psychosocial functioning, defined as secondary impairment, and general psychopathology post‐intervention.ResultsThe number of binge‐eating episodes reduced by an average of 16 binge‐eating episodes per 4 weeks pre‐intervention to five binge‐eating episodes during the last 4 weeks of treatment. Abstinence from binge eating was reported by 30%, and 28% reported full recovery. Effect sizes (Cohen's d) were large (d ≥ 1.0) for all outcome measures. There were no differences in outcomes between the ITT and the completers sample.DiscussionGuided self‐help CBT‐E is associated with significant improvements. The effects of guided self‐help CBT‐E offered in a real‐world‐setting are comparable to self‐help CBT‐E offered in a randomized‐controlled‐trial. However, it should be noted that comparisons with randomized‐controlled‐trials requires caution. Longer‐term follow‐up data are necessary to measure persistence of treatment benefits.Public SignificanceOffering CBT‐E as a web‐based guided self‐help intervention has several benefits for patients with BED. Guided self‐help CBT‐E is associated with significant improvements on the short term when offered in real‐world clinical settings.
High‐resolution data are necessary to understand the effects of climate on plant population dynamics of a forest herb
Authors: Christiansen Ditte M. , Römer Gesa , Dahlgren Johan P. , Borg Malin , Jones Owen R. , Merinero Sonia , Hylander Kristoffer , Ehrlén Johan 
Published: October 2023

AbstractClimate is assumed to strongly influence species distribution and abundance. Although the performance of many organisms is influenced by the climate in their immediate proximity, the climate data used to model their distributions often have a coarse spatial resolution. This is problematic because the local climate experienced by individuals might deviate substantially from the regional average. This problem is likely to be particularly important for sessile organisms like plants and in environments where small‐scale variation in climate is large. To quantify the effect of local temperature on vital rates and population growth rates, we used temperature values measured at the local scale (in situ logger measures) and integral projection models with demographic data from 37 populations of the forest herb Lathyrus vernus across a wide latitudinal gradient in Sweden. To assess how the spatial resolution of temperature data influences assessments of climate effects, we compared effects from models using local data with models using regionally aggregated temperature data at several spatial resolutions (≥1 km). Using local temperature data, we found that spring frost reduced the asymptotic population growth rate in the first of two annual transitions and influenced survival in both transitions. Only one of the four regional estimates showed a similar negative effect of spring frost on population growth rate. Our results for a perennial forest herb show that analyses using regionally aggregated data often fail to identify the effects of climate on population dynamics. This emphasizes the importance of using organism‐relevant estimates of climate when examining effects on individual performance and population dynamics, as well as when modeling species distributions. For sessile organisms that experience the environment over small spatial scales, this will require climate data at high spatial resolutions.
Investigation on risk fields assessment in the longwall working face with single side roof cutting along the gob
Authors: Min Rui , Liu Jinzhao , Chen Xiangjun , Wang Lin 
Published: October 2023

AbstractThe number of mines using roof cutting and pressure relief technology to extract mine deep coal resources is increasing daily. Most of these mines are facing the risk of high gas emission and residual coal spontaneous combustion disasters, and the composite disasters caused by these two risks also threaten the safety of mine production. On the basis of constructing a model for the evolution of porosity and permeability in a single side roof cutting along the gob, this study studied the occurrence locations of gas explosion risk areas, oxidation and heating risk areas, and composite disaster areas under different air supply and gas emission conditions, and summarized the evolution laws of composite disaster risk areas. The research results show that the roof rock collapse caused by roof cutting and pressure relief technology reduces the permeability of porous medium, which significantly reduces the sensitivity of the width of the oxidation temperature rise zone and the composite disaster area to the air supply. The increase in air supply causes the position of the composite disaster risk zone inside the goaf to shift toward the deep part of the goaf, while the width remains basically unchanged. The increase in gas emissions has suppressed the occurrence of coal spontaneous combustion in the goaf, while also keeping the gas concentration in a large area outside the upper limit of gas explosion. The research content enriches the research system of gas and oxygen flow fields in the goaf cutting face, and has positive significance for the promotion and application of goaf cutting technology and the understanding of secondary disasters caused by it.
Novel approaches for lemon grass essential oil extraction: Ultrasound sonication and sparger‐based microwave assisted extraction as a combined technique
Authors: Dhotre Irsha , Sathe Vivek 
Published: October 2023

AbstractThe utilization of essential oils spans across various industries, encompassing food, pharmaceuticals, and cosmetics. Lemongrass, an herb renowned for its high essential oil content, was the focal point of this research. The objective was to explore a novel approach to extract essential oil from lemongrass by employing ultrasonic sparger‐based microwave‐assisted extraction (U Sp‐MAE) coupled with ultrasound sonicator pretreatment. The findings revealed that the application of the U Sp‐MAE technique, combined with ultrasound sonicator pretreatment, resulted in a significant increase in lemongrass essential oil yield. At a mixing ratio of 80 g of chopped lemongrass per 500 mL of deionized water, a remarkable yield of 1.87% was achieved. This study demonstrates the potential of the U Sp‐MAE technique, with ultrasound sonicator pretreatment, as a promising and efficient method for extracting essential oil from lemongrass. Furthermore, its potential applications extend to industrial settings, offering new avenues for utilization.
Sustainable Production Insight Through LCA and LCC Analysis of Injection Overmolded Structural Electronics Manufactured through Roll‐to‐Roll Processes
Authors: Räikkönen Minna , Sokka Laura , Hepo‐oja Lotta , Nordman Sirpa , Kraft Thomas M. 
Published: October 2023

AbstractPrinted electronics (PE) have provided new material and application opportunities for devices and systems as well as new manufacturing routes that all need to be considered for commercialization. This paper introduces a case study with universally relevant manufacturing processes and applications in the PE area, focusing on the Life Cycle Assessment (LCA) and Life Cycle Costing (LCC) of the Personal Activity Monitor (PAM) device. In the study, the PAM device's most important costs and environmental impacts during the prototype pilot production and device use phases are identified and assessed. Additionally, the potential environmental impacts of post‐consumption scenarios are considered. The LCA results indicate that the roll‐to‐roll (R2R) assembly of electronics and the R2R injection over‐molding are generally the most prominent production process steps affecting the results. From the LCC perspective, the capitial expenditure (CAPEX) contributor is the R2R assembly pilot line, due to its high investment cost and long operating time compare to other production assets. The traditional electronic components are the major operating expenditures (OPEX), especially the microcontroller units (MCUs) and accelerometers, in contrast to the low impact from the printed electronics. There are several advantages to applying LCA and LCC since they provide explanations of the relationships between cost, environmental, design, and manufacturing characteristics.
Appearance of α‐Smooth Muscle Actin in Peritubular Cells of Monkey Testes Is Induced by Androgens, Modulated by Follicle‐Stimulating Hormone, and Maintained after Hormonal Withdrawal
Authors: SCHLATT STEFAN , WEINBAUER GERHARD F. , ARSLAN MUHAMMAD , NIESCHLAG EBERHARD 
Published: October 2023

AbstractThis study analyzed the hormonal requirements necessary for the development of primate testicular peritubular cells. Alpha‐smooth muscle actin, as a specific differentiation marker for peritubular cells, was immunohistochemically detected in the testes of immature rhesus and adult rhesus and cynomolgus monkeys. Positive staining was localized in the wall of blood vessels and in peritubular myoid cells of adult animals. In the testis of vehicle‐treated immature monkeys no positive staining could be detected in peritubular cells. Following follicle‐stimulating hormone (FSH) or testosterone treatment, immunostaining for α‐smooth muscle actin appeared in peritubular cells of immature animals. In comparison to FSH, testosterone was more effective in inducing the differentiation of peritubular cells. The most intense label for α‐smooth muscle actin was, however, obtained after combined treatment with FSH and testosterone. A computer‐assisted image analysis system was used to evaluate semiquantitative data for the α‐smooth muscle actin positive area; this confirmed a significantly higher expression of α‐smooth muscle actin in peritubular cells of immature monkeys after treatment with testosterone plus FSH in comparison to controls. These data present evidence that the differentiation of primate peritubular cells during pubertal sexual development is a hormone‐dependent process, which may be predominantly regulated by androgens. FSH exerted additive effects on the androgen‐induced differentiation of peritubular cells, suggesting that paracrine communication between peritubular cells and Sertoli cells existed. Main‐tenance of peritubular cell differentiation after withdrawal of hormonal stimuli in adult monkeys may be a possible explanation for different hormonal requirements during reinitiation of spermatogenesis after testicular involution.
Vasography: Application of an Epidural Catheter
Authors: LOUGHLIN KEVIN R. , BAGLI DARIUS J. , HURLEY RONALD J. 
Published: October 2023

ABSTRACT: Vasography is an accepted uroradiographic procedure primarily used in the evaluation of infertile men with azoospermia or severe oligospermia. We present a technique of utilizing an epidural catheter to facilitate vasography.The role of vasography in the treatment of the male genitourinary system has evolved over the years. In the past, it has been used in the diagnosis and staging of prostate cancer (Beck et al, 1978), congenital disorders (Gibbons et al, 1978), and the treatment of genitourinary infections (Fourcade and Jardin, 1981). However, in the modern era, vasography has been used primarily in the treatment of infertile men with azoospermia or severe oligospermia.Most urologists feel that vasography should be performed in men with azoospermia or severe oligospermia who have normal gonadotropins, palpable bilateral vas deferens, and a testicular biopsy documenting spermatogenesis.
Machine learning‐based antioxidant protein identification model: Progress and evaluation
Authors: Meng Chaolu , Pei Yue , Bu Yongbo , Zou Quan , Ju Ying 
Published: October 2023

AbstractEfficient and accurate identification of antioxidant proteins is of great significance. In recent years, many models for identifying antioxidant proteins have been proposed, but the low sensitivity and high dimensionality of the models are common problems. The generalization ability of the model needs to be improved. Researchers have tried different feature extraction algorithms and feature selection algorithms to obtain the most effective feature combination and have chosen more appropriate classification algorithms and tools to improve model performance. In this article, we systematically reviewed the data set of the most frequently used antioxidant proteins and the method selection for each step of model establishment and discussed the characteristics of each method. We have conducted a detailed analysis of recent research and believe that the practical ability and efficiency of model application can be improved by reducing model dimensions. The key to improving the performance of antioxidant protein recognition models in the future may lie in feature selection, so this paper also focuses on the combination of feature extraction and selection steps in the analysis of the model building process.
Sonocatalytic degradation of nitrobenzene with metal oxide clay nanocomposites
Authors: Saini Pooja , Chakinala Nandana , Surolia Praveen K. , Chakinala Anand Gupta 
Published: October 2023

AbstractBACKGROUNDThe presence of a wide range of persistent toxic organic pollutants in industrial effluents poses a serious threat to human and environmental health, emphasising the necessity for developing cost‐effective methods for treating toxic effluents. This study focuses on the synthesis, characterization and evaluation of metal oxide [iron (Fe), copper (Cu) and zinc (Zn)]‐doped clay composite for the sonocatalytic degradation of nitrobenzene (NB) in the presence of ultrasound.RESULTS AND CONCLUSIONSAmong the metal oxides studied, Cu and Fe oxide‐modified clay performed better in the degradation of NB (~99% in the presence of air) compared to a ZnO/clay composite. Process optimization studies were carried with CuO/clay composite at different pHs (2.5–11.5), feed concentrations (50–200 mg L−1) and catalyst loadings (0.25–1.0 g L−1). Neutral pH conditions and higher catalyst loadings of 1 g L−1 were found to be optimal for the efficient degradation of 50 ppm NB. Among the scavengers tested, ethylenediamine tetra acetic acid exhibited strong scavenging effects, resulting in reduced NB degradation compared to isopropyl alcohol and tin tetrachloride, regardless of the scavenger concentration (0.5 and 40 mmol L−1). The catalyst was found to be sufficiently stable for up to four cycles under identical conditions. Additionally, these materials were found to be effective in the degradation of other pollutants [Terephthalic acid, Rhodamine‐B, Ciprofloxacin]. These findings contribute to the development of cost‐effective strategies for the treatment of industrial effluents, reducing the risks posed to both the environment and human health. © 2023 Society of Chemical Industry (SCI).
Microlearning: Evidence‐based education that is effective for busy professionals and short attention spans
Authors: Ingram Nissen Therese , Edelman Emily A. , Steinmark Linda , Logan Kalisi , Reed E. Kate 
Published: October 2023

AbstractMicrolearning uses short educational interventions to provide learners with the necessary knowledge and skills to perform specific tasks or solve immediate problems. This approach is increasingly used across digital platforms to engage learners and foster quick comprehension. Microlearning can be used in clinical genetics education to deliver a comprehensive educational intervention that is segmented into smaller discrete but complimentary components. This report discusses one group's approach to using microlearning in clinician education and provides tips that can be applied to other educational efforts. High‐quality genetics education has the potential to be disseminated across multiple delivery methods and to multiple audiences, thereby increasing its impact and reach.
Characterizing the research mentorship experience of genetic counseling students
Authors: Steber Hannah S. , Fishler Kristen P. , McBrien Sarah B. 
Published: October 2023

AbstractThe Accreditation Council for Genetic Counseling's Practice‐Based Competencies include research‐related skills, which are taught in master's level genetic counseling programs through didactic coursework and completion of mentored research experiences. It is known that research mentors can impact student work environments, create positive perceptions of the research process, and increase students' likelihood of future involvement in research. However, few studies have characterized the experiences of GC students in receiving research mentorship. It is crucial to understand these experiences from student perspectives to better inform stakeholders about factors that impact mentorship. Using a mixed‐methods approach, this study explored GC students' experiences receiving research mentorship and their thoughts regarding the successful qualities of research mentors. GC students (N = 165) who graduated between 2019 and 2022 responded to an online survey measuring the mentorship relationship, defined by the Advisory Working Alliance Inventory (AWAI). On average, participants scored 3.96/5 on the AWAI, where higher scores indicate stronger working alliances. When asked to describe their overall research experience in three words, 75.7% of participants used at least one negatively connotated descriptor. Thematic analysis of semi‐structured interviews obtained via purposive sampling of highest and lowest scoring participants on the AWAI (N = 14) revealed the following five themes related to successful qualities of a research mentor: (1) communication; (2) rapport building and relationship; (3) engagement and guidance; (4) expertise and connections; and (5) mentors with different roles. Of note, many of these qualities are foundational skills in genetic counseling. Thus, genetic counselors who may be strong in these areas who do not identify as “researchers” ought to consider becoming a research committee member. Additionally, education programs could consider implementing research committee member evaluations and/or student research self‐efficacy surveys to evaluate how these relationships may be shaping research experiences for students within their program.
Synthesis of new 2‐pyridinone and thiazole derivatives containing coumarin moiety
Authors: Al‐Harbi Reem A. K. , Emam Heba A. , Abbas Samir Y. 
Published: October 2023

AbstractCoumarin has shown considerable therapeutic potency because of its versatile biological prosperities. Also, pyridines have been adopted in medicinal chemistry as potent ring. Moreover, several investigations reported the potency of thiazole‐containing compounds. So, during this research, new functionalized 2‐pyridinone and thiazole derivatives bearing coumarin moiety were aimed to synthesize. Many trials to obtain the 6‐amino‐2‐oxo‐pyridine‐3,5‐dicarbonitriles through the condensation of cyanoacetohydrazone of 3‐acetyl coumarin with 2‐(arylidene)malononitriles were carried out using different reaction conditions. In all cases, the reaction gave none of the corresponding 2‐pyridinone derivatives except the reaction with 2‐(benzylidene)‐malononitrile afforded product in few yield. Moreover, the reaction of another cyanoacetanilide with the 2‐(arylidene)‐malononitrile afforded the unexpected arylidene derivatives rather than the expected pyridin‐2‐one derivatives. Finally, new thiazoles bearing coumarin moiety were synthesized using 3‐acetylcoumarin N‐(2,4‐dimethoxyphenyl)‐thiosemicarbazone. Cyclization of thiosemicarbazone derivative with ethyl 2‐chloroacetate, chloroacetone or phenacyl bromide afforded in high yields the corresponding derivatives of thiazolidin‐4‐one, 4‐methylthiazole or 4‐phenylthiazole, respectively.
How efficient are metal‐polymer and dual‐metals‐polymer non‐lead radiation shields?
Authors: Salehi Zaker , Tayebi Khorami Mansour 
Published: October 2023

AbstractIntroductionLead shields are often used to attenuate ionising radiations. However, to make lighter, recyclable and more efficient shields compared to lead, combinations of new metallic compounds together with polymer, for example, flexible polyvinyl chloride (PVC) have been developed recently. In this study, the capabilities of non‐lead radiation shields made of one or two metallic compounds and polymer were evaluated.MethodsMonte Carlo (MC)‐based BEAMnrc code was used to build a functional model based on a Philips X‐ray machine in the range of radiographic energies. The MC model was then verified by IPEM Report 78 as a standardised global reference. The MC model was then used to evaluate the efficiency of non‐lead‐based garments made of metallic compound and polymer (MCP) including BaSO4‐PVC, Bi2O3‐PVC, Sn‐PVC and W‐PVC, as well as dual‐metallic compounds and polymer (DMCP) including Bi2O3‐BaSO4‐PVC, Bi2O3‐Sn‐PVC, W‐Sn‐PVC and W‐BaSO4‐PVC. The absorbed doses were determined at the surface of a water phantom and compared directly with the doses obtained for 0.5 mm pure lead (Pb).ResultsBi2O3‐BaSO4‐PVC and W‐BaSO4‐PVC were found to be efficient shields for most of the energies. In addition to the above radiation shields, Bi2O3‐Sn‐PVC was also found to be effective for the spectrum of 60 keV. Bi2O3‐BaSO4‐PVC as a non‐lead dual metals‐PVC shield was shown to be more efficient than pure lead in diagnostic X‐ray range.ConclusionCombination of two metals‐PVC, a low atomic number (Z) metal together with a high atomic number metal, and also single‐metal‐PVC shields were shown to be efficient enough to apply as radiation protection shields instead of lead‐based garments.
Cryotherapy versus topical nitric‐zinc complex solution for the treatment of plantar warts: A randomized controlled trial
Authors: García‐Oreja Sara , Álvaro‐Afonso Francisco Javier , García‐Madrid Marta , López‐Moral Mateo , García‐Álvarez Yolanda , Lázaro‐Martínez José Luís 
Published: October 2023

AbstractCryotherapy is commonly regarded as the primary treatment method for plantar warts. A new medical device called nitric–zinc complex solution (NZCS) has also emerged as a potential alternative for wart treatment. The main aim of this study was to analyze and compare the effectiveness of cryotherapy using liquid nitrogen and NZCS in treating plantar warts. We conducted a randomized and controlled clinical trial involving patients with plantar warts. A total of 62 patients were enrolled in the study and monitored for 12 weeks or until their warts were completely resolved. The patients received either cryotherapy or NZCS, with a maximum of six treatment applications. The cure rate was 65.5% in the group treated with cryotherapy and 56.6% in the group treated with NZCS. The average number of treatment applications required for curing warts was significantly lower in the cured group (3.28 ± 1.63) than in the group with unresolved warts (5.5 ± 1.27) (p < 0.01). Moreover, the average number of applications was lower in the cryotherapy group (3.6 ± 1.8) than in the NZCS group (4.8 ± 1.8) (p < 0.01). Based on the findings, NZCS could be considered a favorable first‐line treatment option for plantar warts.