bluuebunny/crossref_metadata_2025_split huggingface dataset:
EcoBlendNet: A physics-informed neural network for optimizing supplementary material replacement to reduce the carbon footprint during cement hydration
Authors: Rahman Md Asif , Lu Yang 
Published: October 2023

Abstract

The addition of supplementary cementitious materials (SCMs) to cement triggers a complex cement hydration system characterized by intricate mineral admixture interactions. This work develops EcoBlendNet, a novel physics-informed neural network (PINN), to analyze carbon emissions during SCMs-enhanced cement hydration. EcoBlendNet integrates experimental data and the chemo-physical aspects of cement hydration in a heated cement paste, accurately predicting concrete maturity and compressive strength by capturing early-age temperature rises for various mixing blends, including Portland cement, cement-fly ash blends, and cement-slag blends. SCMs effectively reduce temperature rises without compromising strength development. The work illustrates a statistical method to efficiently leverage limited SCMs resources for mitigating environmental impacts in concrete construction. Quantitative analysis reveal that replacing 45–80% of cement with industrial fly ash and slag can reduce CO2 emissions by 60–80% during cement hydration. The validated EcoBlendNet offers a precise and interpretable tool for eco-friendly mixing blend selection, harmonizing with experimental methods. It’s adaptable to different material properties and mineral admixtures, thereby promoting eco-friendly concrete construction.
Influence of visceral fat on cardio-respiratory homeostasis depending on sex, age and presence of arterial hypertension
Authors: Gorban V. V. , Gorban E. V. , Manto V. S. , Svistun O. V. 
Published: October 2023

Introduction. The study of vegetative homeostasis requires the accounting of sensitive, non-invasive parameters of multidimensional ambulatory metabolic and cardiorespiratory monitoring, including bioimedansometry, heart rate variability (HRV) and respiratory function (RF).Aim. To determine concomitant changes in HRV, RF, depending on the level of visceral fat (VF) and the presence of arterial hypertension (AH), associated with gender, age to determine the targets of preventive effects.Materials and methods. 215 boys and girls aged 18 to 30 years and 93 men and women with hypertension aged 45 to 59 years underwent, bioimpedancometry, HRV monitoring using ten-minute recordings, and the study of respiratory function.Results and discussion. In young people with a BMI over 25 kg/m2, a high level of HF was associated with an increase in LF/ HF and SDANN values, which reflected a reduction in parasympathetic activity and an increase in sympathetic activity, as well as changes in RF with a decrease in the Tiffno index and maximum half-expiratory flow (MHF). In middle-aged individuals with AH and BMI exceeding 25 kg/m2, a direct correlation was found between the value of VF and age, waist circumference, diastolic blood pressure, with a higher stress index of cardiac rhythm regulation and more pronounced sympathetic activity in terms of the LF/HF parameter. A lower total HRV, low parasympathetic activity and tension in the regulation of the heart rhythm in persons with AH were detected even with an intermediate value of VF.Conclusions. The study of autonomic homeostasis required the accounting of the individual dynamics of the parameters of HRV and the RF even within normal values. Changes in HRV associated with an intermediate increase in VF should be monitored with an emphasis on SDANN, LF/HF, stress index and vegetative index, and changes in RF – with an emphasis on the Tiffno index and MHF.
Prevention of endometriosis recurrence after surgical treatment
Authors: Apresyan S. V. , Markarov A. E. , Dobrokhotova Ju. E. , Khlynova S. A. , Dimitrova V. I. , Papoyan S. A. , Markova E. A. , Slyusareva O. A. 
Published: October 2023

Introduction. The relevance of studying the mechanisms underlying the development of adenomyosis is determined not only by its high prevalence reaching 40% among reproductive aged women, but also by its association with unexplained infertility (60%), as well as woman’s quality of life impairment.Aim. To enhance efficiency of therapy after surgical treatment of endometriosis and minimize the risk of disease recurrence.Materials and methods. In a cohort prospective comparative study conducted on the basis of the gynecological department of the Inozemtsev City Clinical Hospital, 80 patients of reproductive age who underwent organ-preserving treatment for external genital endometriosis and nodular adenomyosis were included. Dienogest (Zafrilla) was prescribed to 65 patients at a dose of 2 mg/day (1 tablet) from day 2 after surgical treatment continuously for 6 months, taking into account contraindications to its use, 15 patients refused to take the drug in the postoperative period, and made up the control group.Results. The results of the study showed that after surgical treatment of external genital endometriosis and the nodular form of adenomyosis and the appointment of suppressive therapy with Zafrilla, after 3 months, the intensity of the pain syndrome was transformed according to the VAS, NRS, B&B scales by one step, and after 6 months it decreased to a slight (p < 0.05), which contributed to the improvement of the quality of life of patients based on the EHP-30 questionnaire. The long-term results of the study allow us to recommend the drug Zafrilla, with high compliance, good tolerance, a favorable safety profile, in order to reduce pain, the intensity of menstrual flow, and prevent recurrence of the disease based on 24 months of observation.Conclusion. An integrated approach to the treatment of external genital endometriosis and nodular adenomyosis, including surgical treatment and suppressive therapy with Zafrilla, made it possible to realize reproductive function in 48% of patients. Taking dienogest for 24 weeks provided effective relief of pain, alleviated the symptoms of the disease, as well as improved the quality of life and realized reproductive plans.
Review the Role of Metabolism Reprogramming in the Pathogenesis of
Post-surgical Adhesion: A New Therapeutic Strategy
Authors: Aliakbarian Mohsen , Khodashahi Rozita , Tavakkoli Mahmoud , Ashrafzadeh Kiarash , Rahimi Hoda , Khaleghi Ebrahim , Ghayour-Mobarhan Majid , Arjmand Mohammad-Hassan 
Published: October 2023

Abstract:
Metabolic reprogramming is defined as the skill of cells to change their metabolism to
support the induced energy demand due to continuous growth. Metabolic reprogramming is a well-
known occurrence in the progression of neoplastic cells, although, evidence has shown that it is
present in fibrotic disorders. Post-surgical adhesion as a fibrotic disorder is a medical challenge
and is defined by fibrotic bands connected between organs with the abdominal wall. Despite many
investigations carried out about the pathogenesis of the disorder but there are many unknowns,
therefore, targeting special pathways may have the potential to prevent the formation of fibrotic
bands post-operative. Glycolysis is a necessary metabolic pathway in living cells. In hypoxic conditions,
it is the dominant pathway in the production of energy for different types of cells such as
fibroblasts, immune cells, and endothelial cells. Also, glycolysis is a main downstream target for
transforming growth factor β (TGF-β) and upregulates during fibrotic conditions. Furthermore,
this is noteworthy that hypoxia induces factor 1 alpha (HIF-1α) as a transcription factor, elevated
during the hypoxia condition stimulates different signaling pathways such as TGF-β/SMAD, nuclear
factor kappa B (NF-kB), and mTOR pathway to control glycolytic metabolism and T-cell
trafficking for immune cell migration. Different evidence has indicated that the administration of
glycolytic inhibitors has the potential to prevent the development of fibrotic markers. In this review,
we pointed out the role of the glycolysis pathway and its connection to profibrotic cytokines
to promote inflammatory and fibrotic pathways. Based on the results of studies related to fibrotic
disorders we hypothesized that targeting glycolysis may have therapeutic potential in the prevention
of postoperative adhesions.
Toxicological Assessment and Anti-diabetic Effects of Combined Extract
of Chirata, Fenugreek and Sesame on Regulating TNF-α, TGF-β and
Oxidative Stress in Streptozotocin Induced Diabetic Rats
Authors: Shivam  , Gupta Asheesh Kumar 
Published: October 2023

Background:
Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum are
used as traditional medicines to treat diabetes mellitus. A collection of metabolic illnesses known as
diabetes mellitus (DM) involves chronic hyperglycemia caused by flaws in insulin secretion, function, or both. Innate immunity and inflammation both play important roles in the etiology of diabetes-related microvascular problems.

Objective:
This study aims to examine the anti-diabetic effects and the acute toxicity of combined
extract (1:1:1) of Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum. To address
the demand for higher effectiveness and safety, the current effort aims to construct anti-diabetic
preparations containing methanolic extract from herbal medications.

Methods:
The OECD 423 method was used to investigate acute toxicity in rats. Rats were used as
test subjects, and rats were given a 35 mg/kg BW injection of streptozotocin to develop diabetes.
The diabetic control group was given Glibenclamide 25 mg/kg BW, while the experimental group's
diabetic rats received 125 mg/kg BW and 250 mg/kg BW of a combined methanolic extract of all
plants. Among the measurements looked at were acute oral toxicity, behavioral changes, body
weight, serum glucose levels, lipid profiles, oxidative stress, renal function tests, and inflammatory
mediators. All the rat groups' histopathologies of the kidney, liver, and stomach were compared.
The data were evaluated using analysis of variance, and a post hoc test was then carried out.

Results:
The combined extracts' medium lethal doses (LD50) were higher than 2000 mg/kg, indicating that they are not poisonous under the conditions that can be observed. Streptozotocin-induced
diabetic rats' elevated blood glucose was found to be considerably lower (p 0.01) in the treated
group of rats. In the treated group of rats, it was discovered that the damage and disarray in the cells
typical of Streptozotocin-induced DM had been repaired. The treated group of rats returned to normal levels of the lipid profile, hyperglycemia, decreased serum protein and liver glycogen, increased liver function, and kidney function markers seen in the rats of the DM control group.

Conclusion:
The evaluated combined methanolic extract can be considered safe for use in rats.
Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed
as an alternative medicine.
Potential Roles for B cells and Autoantibodies in Ankylosing Spondylitis
Authors: Soltani Samaneh , Jamshidi Ahmadreza , Mahmoudi Mahdi , Farhadi Elham 
Published: October 2023

Abstract:
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that predominantly
affects young males. AS is a condition in which the spine and sacroiliac joints become inflamed.
More specifically, most AS patients experience spine malformations over time, resulting
in functional incapability. The etiopathogenesis of AS is a complex combination of genetic predisposition
and environmental factors. Extensive studies on AS have revealed the central role of genetics
and immune reactions in its etiology. However, an utmost agreement has yet to be created.
The available evidence suggests that both autoinflammation and T-cell-mediated autoimmune processes
have significant roles in the disease process of AS. So far, B cells have obtained moderately
little attention in AS pathogenesis, primarily because of the absence of disease-defining autoantibodies.
However, against general dogma, evidence is mounting showing B cell involvement.
Disruptions depict this in circulating B cell populations, the increased expression of immunoglobulin
(Ig)G, IgA, and IgM, and B cell infiltration within the axial skeleton of AS patients.

:
Meanwhile, compared to many other inflammatory autoimmune disorders, AS has no disease-specific
autoantibodies that help disease diagnosis. This study has provided an overview of the B lymphocytes
and antibodies' role in AS pathogenesis. It also introduces autoantibodies that can be the
prognosis and diagnosis biomarkers of AS.
Diabetic Neuropathy: An Overview of Molecular Pathways and Protective
Mechanisms of Phytobioactives
Authors: Hashim Mohd , Badruddeen  , Akhtar Juber , Khan Mohammad Irfan , Ahmad Mohammad , Islam Anas , Ahmad Asad 
Published: October 2023

Abstract:
Diabetic neuropathy (DN) is a common and debilitating complication of diabetes
mellitus that affects the peripheral nerves and causes pain, numbness, and impaired function.
The pathogenesis of DN involves multiple molecular mechanisms, such as oxidative stress, inflammation,
and pathways of advanced glycation end products, polyol, hexosamine, and protein
kinase C. Phytochemicals are natural compounds derived from plants that have various biological
activities and therapeutic potential. Flavonoids, terpenes, alkaloids, stilbenes, and tannins are
some of the phytochemicals that have been identified as having protective potential for diabetic
neuropathy. These compounds can modulate various cellular pathways involved in the development
and progression of neuropathy, including reducing oxidative stress and inflammation
and promoting nerve growth and repair. In this review, the current evidence on the effects of
phytochemicals on DN by focusing on five major classes, flavonoids, terpenes, alkaloids, stilbenes,
and tannins, are summarized. This compilation also discusses the possible molecular targets
of numerous pathways of DN that these phytochemicals modulate. These phytochemicals
may offer a promising alternative or complementary approach to conventional drugs for DN
management by modulating multiple pathological pathways and restoring nerve function.
Implementation of Secure and Verifiable Access Control Procedures using the NTRU Cryptosystem to Store Big Data in the Cloud Environment
Authors: Babu B. Ravindra , Saxena Swati , Widjaja Gunawan , Vinodha D. Vedha , Omarov Batyrkhan , Ramaiah Gurumurthy B. , Vats Prashant 
Published: October 2023

Background:
Due to their complexity and size, deploying ciphertexts for clouds is considered the most useful approach to accessing large data stores.

Method:
However, access to a user's access legitimacy and improving a decrypted text on the
cloud depending on an improved access policy (AP) specified by the data owner are the key challenges for making large data storage realistic and effective in clouds. The traditional ways either
totally remove the problem of AP development or offer renewal to arbiter power, but in real-time,
enhancing the AP is essential to maximising security and handling agility.

Results:
In this paper, a safe and verifiable access control program characterised by the NTRU
cryptographic system for large storage of data in the clouds is proposed. Primarily, an improved
NTRU decryption protocol to deal with the decryption failures of the prime NTRU is established,
and in addition, the program is analysed for its security strength and computational performance.
When a new AP is specified by the data owner, the cloud server allows the program to improve
ciphertext and allows the owner to verify the upgrade to oppose the cloud's fraudulent behaviour.

Conclusion:
It enables (i) checking the user's legitimacy to access the data owner and qualified
users, and (ii) allowing the user to verify the data provided by other users for the recovery of the
right user. Strong analysis can prevent and block delinquency from various attacks, namely the
collusion attack that could potentially target fraud users.
Learning by doing y rendimiento académico en estudiantes de Administración de Empresas
Authors: Cortés Bracho Oriana , Betancourt Rodriguez Libnazaret , Mejía Turizo Jorge , Ojeda Beltrán Adelaida del Carmen 
Published: October 2023

Introduction: Traditional education in the classroom has been questioned in its ability to respond to the needs of the knowledge society, so the center of the discussion is directed to the change of methodologies that are more suitable and coherent with the environment, such as the learning by doing methodology, expressed as experiential learning that forces the student to solve problems outside the classroom. Objective: The objective of this article is to analyze how the Learning by Doing methodology is related to the academic performance of business administration students. Methodology: the comparison of the final grades of two groups of students is proposed: group A made up of a sample of 34 students (control group that took the subject in the first semester of 2022, in the traditional way) and group B (experimental group that took the subject in the second semester of 2022 under the aforementioned methodology) made up of a sample of 29 students. Likewise, group B was measured at two moments (before and after having participated in learning by doing activities) with a pre and post test. Results: The results showed an improvement in the grades of group B, additionally an improvement in leadership, innovation and creativity skills was observed in the students of this group. Conclusions: This research highlights the need to adopt methodologies such as learning by doing in the training of business administrators.
Implementasi Metode dan Strategi Pembelajaran Berbasis ICT
Authors: Syakur Abd , Susilo Tri Achmad Budi , Mubarok M Khusni 
Published: October 2023

Penerapan pembelajaran di Lembaga Pendidikan Anak Usia Dini tidak cukup hanya menyenangkan, akan tetapi proses belajar yang aktif, inovatif, kreatif, dan efektif. Posisi guru sebagai pemeran inti, menjadi penentu keberhasilan pembelajaran. Guru dituntut memiliki kemampuan dalam metode dan strategi pembelajaran berbasis teknologi dan informasi. Kegiatan pengabdian kepada masyarakat dengan tema Pendampingan Metode dan Strategi Pembelajaran Berbasis Teknologi dan Informasi di Lembaga Pendidikan Anak Usia Dini Miftahul Amal Ellak Daya Lenteng Sumenep ini, menggunakan metode Asset Based Community Development (ABCD) yang teridiri dari pemetaan potensi aset, rencana aksi, pelaksanaan kegiatan, dan monitoring serta evaluasi. Hasil pengabdian di antaranya; Pertama, penguasanaan guru dalam metode dan strategi pembelajaran. Kedua, Guru memiliki kemampuan dalam mengoperasional komputer berbasis internet. Ketiga, Penguasaan metode dan stretagi pembelajaran berbasis teknologi dan informasi (ICT). Keempat, Guru mampu mengimplementasi metode pembelajaran bermain berbasis berbasis teknologi dan informasi (ICT).

The implementation of learning in Early Childhood Education Institutions is not just fun, but the learning process is active, innovative, creative and effective. The teacher's position as a core actor determines the success of learning. Teachers are required to have abilities in technology and information-based learning methods and strategies. This community service activity with the theme Assistance with Technology and Information Based Learning Methods and Strategies at the Miftahul Amal Ellak Daya Lenteng Early Childhood Education Institution, Sumenep, uses the Asset Based Community Development (ABCD) method which consists of mapping potential assets, action plans, implementation of activities , and monitoring and evaluation. The results of service include; First, teacher mastery of learning methods and strategies. Second, teachers have the ability to operate internet-based computers. Third, mastery of technology and information (ICT) based learning methods and strategies. Fourth, teachers are able to implement technology and information (ICT) based play learning methods.
Kode-Kode Narasi Semiotika Roland Barthes dalam Novel dari Jendela SMP Karya Mira Widjaja
Authors: Lestary Ayu Diah , Warni Warni , Wulandari Sovia 
Published: October 2023

Penelitian ini bertujuan mendeskripsikan jenis dan makna kode-kode narasi semiotika Roland Barthes dalam novel Dari Jendela SMP(DJS) karya Mira Widjaja. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan jenis penelitian studi pustaka. Data penenelitian berupa leksia yang terdapat dalam novel DJS karya Mira Widjaja. Sumber data yang digunakan novel DJS karya Mira Widjaja yang diterbitkan oleh PT Gramedia Pustaka Utama, cetakan ketiga belas yang terbit pada tahun 2009. Hasil penelitian menunjukan bahwa novel DJS ditemukan kelima kode narasi semiotika Roland Barthes yang juga mengandung beberapa unsur-unsur intrinsik, yaitu: (1) kode hermeneutik berupa teka-teki yang berbentuk pertanyaan dan jawaban teka-teki, (2) kode semik berupa metafora dan konotasi dari latar, tokoh dan penokohan, (3) kode simbolik berupa penyimbolan pada narasi dan tema cerita, kode proaretik berupa runtutan alur dengan rangkaian aksian dan akibat aksian, kode gnomik berupa wujud kebudayaan yang berbentuk gagasan, mitos, etika, tradisi, dan bahasa. Kesimpulan dari penelitian ini adalah novel DJS karya Mira Widjaja memiliki jenis kode narasi semiotika Roland Barthes yaitu: (1) kode hermeneutik berupa pertanyaan dan jawaban teka-teki, (2) kode semik berupa metafora dan konotasi latar, tokoh dan penokohan, (3) kode simbolik berupa penyimbolan narasi dan tema cerita, (4) kode proaretik berupa runtutan alur dengan rangkaian aksian dan akibat aksian, (5) kode gnomik berupa gagasan, mitos, etika, tradisi, dan bahasa
Aspek Postmodernisme pada Novel Orang-orang Oetimu Karya Felix K. Nesi
Authors: Pakpahan Kevin Rey , Warni Warni , Wilyanti Liza Septa 
Published: October 2023

Penelitian ini merupakan penelitian postmodernisme. Tujuann penelitian ini adalah untuk mendeskripsikan aspek postmodernisme dalam novel Orang-Orang Oetimu karya Felix K. Nesi. Metode penelitian ini ialah deskriptif kualitatif. Data dari penelitian ini adalah satuan-satuan kata, frasa, kalimat, paragraf ataupun ungkapan mengandung aspek postmodernisme yang terdapat pada novel Orang-Orang Oetimu karya Felix K. Nesi. Hasil dari penelitian ini ditemukan 14 data analisis aspek postmodernisme secara keseluruhan, yaitu 2 data yang merujuk pada ekletisisme, 5 data yang merujuk pada parodi, 6 data yang merujuk pada ironi dan 1 data yang menunjuk tidak ada batasan antara seni rendah dan tinggi Berdasarkan hasil penelitian, maka dapat disimpulkan bahwa aspek yang ditemukan dalam novel ini adalah aspek ironi, parodiekletisisme, dan tidak ada batasan antara seni rendah dan seni tinggi.