bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass Spectrometric Phenotyping of Val34Leu Polymorphism of Blood Coagulation Factor XIII by Differential Peptide Display
Authors: Tammen Harald , Möhring Thomas , Kellmann Markus , Pich Andreas , Kreipe Hans H , Hess Rüdiger 
Published: February 2004

Abstract
Background: The Val34Leu mutation in the activation peptide of factor XIII (FXIIIA) correlates with a lower incidence of myocardial infarction and ischemic stroke but an increased risk for hemorrhagic stroke. We describe mass spectrometric detection of the activation peptide variants in human serum.
Methods: We used differential peptide display (DPD) to compare comprehensive peptide maps from pairs of serum samples from healthy volunteers. Peptides were separated by liquid chromatography, and fractions were subjected to mass spectrometry. Mass spectra of all fractions were combined, giving a peptide map representing a two-dimensional display of peptide masses. After comparison of peptide mass maps, peptides that differentiated FXIIIA phenotypes were identified by mass spectrometry.
Results: Val34Leu polymorphisms of the activation peptide of FXIIIA were identified in 20 serum samples from 10 volunteers by DPD, and their sequences were confirmed by nanoelectrospray-ionization quadrupole time-of-flight mass spectrometry. Analysis of three (V34V, V34L, and L34L) phenotypes was confirmed by allele-specific genotypic analysis in all (n = 10) volunteers.
Conclusion: DPD provides a simple and easy-to-use phenotype assay with advantages over PCR-based assays in being faster and directly analyzing the compound of interest.
Association of Coronary Heart Disease with Pre-β-HDL Concentrations in Japanese Men
Authors: Hattori Hiroaki , Kujiraoka Takeshi , Egashira Tohru , Saito Eiji , Fujioka Takayuki , Takahashi Sadao , Ito Mayumi , Cooper Jackie A , Stepanova Irina P , Nanjee M Nazeem , Miller Norman E 
Published: February 2004

AbstractBackground: In individuals heterozygous for ABCA1 transporter mutations, defective reverse cholesterol transport (RCT) causes low HDL-cholesterol and premature coronary heart disease (CHD). However, the extent to which impaired RCT underlies premature CHD in others with low HDL-cholesterol is not known. The primary acceptors of cell cholesterol are a minor subclass of lipid-poor pre-β-HDLs. These are generated during remodeling of α-HDLs, which account for almost all HDL-cholesterol. We studied the strength of the association of CHD with pre-β-HDL concentrations in Japanese men.Methods: Blood was collected from 42 men with clinical CHD and 44 healthy controls 40–70 years of age. Pre-β-HDL was assayed by crossed immunoelectrophoresis.Results: Cases had lower HDL-cholesterol (−23%), total apolipoprotein A-I (−26%), and pre-β-HDL (−55%; all P &lt;0.001) concentrations; lower pre-β-HDL:α-HDL ratios (−45%; P &lt;0.001); and higher plasma triglycerides (20%; P &lt;0.03) than the controls. On stepwise logistic regression, CHD was associated most strongly with pre-β-HDL concentrations. On ROC analysis, pre-β-HDL concentration discriminated between cases and controls better than any other lipoprotein measurement. When plasma was incubated for 16 h at 37 °C, mean (SD) pre-β-HDL increased by 47 (36)% in controls, but was unchanged in cases (group difference, P &lt;0.001).Conclusions: Our results suggest that inefficient RCT, secondary to a low pre-β-HDL concentration and production rate in plasma, contributes to premature CHD in Japanese men with low HDL-cholesterol.
Wahrnehmungsbewusstsein in der Automation – ein neuer „bionischer“ Denkansatz (Perception Awareness in Automation – A New "Bionic" Approach)
Authors: Dietrich Dietmar , Kastner Wolfgang , Schweinzer Herbert 
Published: February 2004

Abstract
Die Kommunikation in der Automatisierung führt zu immer höherer Komplexität, die nicht nur ein Umdenken für die Entwickler notwendig werden lässt, sondern auch grundsätzlich neue Modelle erfordert. Die Kommunikation über Feldbusse ist dabei heute die Voraussetzung, dass Computer Integrated Manufacturing (CIM) wirtschaftlich greifen kann und dass die Gebäudeautomation eine bedeutende Stellung mit Auswirkungen auf die Architektur gewonnen hat. Die Feldbusse sollten deshalb auch eine Schlüsselfunktion in der weiteren Modellentwicklung einnehmen. Von ihnen soll ausgegangen werden. Betrachtet man biologische und psychologische Modelle, erhält man mögliche Antworten, wie solche Modelle in der Automation aussehen könnten. Im vorliegenden Beitrag werden grundlegende Lösungsansätze formuliert, die in gemeinsamen Forschungsaktivitäten mehrerer Institute in den letzten Jahren erarbeitet wurden und in weiterer Folge von reiner Theorie in Praxis umgesetzt werden. Ziel ist ein neuer Ansatz, ein neues hierarchisches Automationsmodell, das Allgemeingültigkeit für viele Bereiche haben kann. Ein entscheidendes Moment ist, dass sich die folgenden Überlegungen von traditionellen Ansätzen lösen, die Vorgehensweise stellt aber im Grunde einen konsequenten Schritt hinsichtlich moderner Forschungsergebnisse dar. Bisher haben sich derartige Ansätze allerdings vor allem auf rein neurologische Überlegungen gestützt, die mit Hilfe der naturwissenschaftlichen Denkweise noch nachzuvollziehen sind, während im Folgenden neueste Ergebnisse der Grundlagenforschung der Wissenschaften der Pädagogik, Psychologie und Psychoanalyse zugrunde gelegt werden, ohne diese jedoch hier breit aufzubereiten.
Ein erweitertes, adaptives Kraftstoffzuteilungskonzept für den Ottomotor (Extended Nonlinear-Adaptive Engine Fuel Supply Control for Spark Ignition Engines)
Authors: Jakubek Stefan , Keuth Nikolaus , Bamer Franz 
Published: February 2004

Abstract
Der Artikel beschreibt zwei neue Methoden zur verbesserten Kraftstoffzuteilung für Verbrennungskraftmaschinen: Die erste eliminiert stationäre Fehler, die z.B. durch ungenaue Kennfelder des volumetrischen Wirkungsgrades oder fehlerhafte Luftmessungen entstehen. Die zweite Methode reduziert instationäre Fehler. Bei Lastsprüngen bildet sich im Ansaugtrakt ein flüssiger Treibstoffwandfilm, was zu einer Abmagerung des Gemisches führt. Um diesen Effekt zu korrigieren, wird eine Zusatzmasse eingespritzt, welche durch ein diskretes Filter berechnet wird. Das Hauptproblem war, einen praxisgerechten und robusten Weg zu finden, um die Filterparameter ausgehend von den verfügbaren λ-Messungen zu adaptieren. Die Leistungsfähigkeit der präsentierten Methoden, gemeinsam mit den entsprechenden Adaptionsalgorithmen, wird anhand von Simulationen mit einem physikalischen Modell eines Ottomotors gezeigt. Die Methoden erreichen in allen Arbeitspunkten des Motors λ-Abweichungen von weniger als einem Prozent.
Berührungsthermometer und ihre Messunsicherheiten in industriellen Anwendungen (Contact Thermometers and their Uncertainties in Industrial Applications)
Authors: Tegeler Erich 
Published: February 2004

Abstract
Temperaturen werden in der überwiegenden Zahl der Fälle mit Thermoelementen oder Widerstandsthermometern gemessen. Anhand von Beispielen werden die wesentlichen in der Praxis auftretenden Schwierigkeiten bei der Temperaturmessung und die damit verbundenen Messunsicherheiten behandelt. Neben der Unsicherheit der Kalibrierung und der Ankopplung des Thermometers an das Messobjekt gehören hierzu auch parasitäre Thermospannungen, verfälschende Leitungswiderstände, Inhomogenitäten von Thermodrähten und verfälschende Strahlungseinflüsse.
Decentralized event‐triggered output feedback adaptive neural network control for a class of MIMO uncertain strict‐feedback nonlinear systems with input saturation
Authors: Bey Oussama , Chemachema Mohamed 
Published: January 2024

SummaryFor a class of multiple‐input multiple‐output large‐scale nonlinear systems in strict‐feedback form with input saturation, external disturbances and immeasurable states, an adaptive decentralized neural network (NN) control strategy on the basis of event triggered mechanism is investigated in this article. In contrast to the literature, the proposed method is centered on the control‐error as a replacement to the tracking‐error that leads to a simplified derivation approach of adaptive laws. Furthermore, the control gains for this class of systems are considered unknown nonlinear functions and not assumed as simple unity or known gains as always done in the literature. Moreover, the challenge of losing controllability that typically arises in state transformation‐based methods, as reported in the literature, is entirely resolved in our approach. Last and not least, all restrictions imposed on unmatched interconnections are eliminated along with avoiding the complexity explosion caused by recursive back‐stepping designs. For this end, the unknown ideal control laws are approximated using NNs, while additional control terms are added to handle saturation effects, unknown interactions, and approximation errors. Additionally, fuzzy inference systems are employed to estimate unknown control errors. Due to the strictly positive real property, the tracking errors are proved to belong to a small compact set using Lyapunov theory. Simulation results demonstrate the effectiveness of the proposed approach.
Electronic Structure Engineering in NiFe Sulfide via A Third Metal Doping as Efficient Bifunctional OER/ORR Electrocatalyst for Rechargeable Zinc‐Air Battery
Authors: Sari Fitri Nur Indah , Lai Yi‐Cheng , Huang Yan‐Jia , Wei Xuan‐Yu , Pourzolfaghar Hamed , Chang Yu‐Hao , Ghufron Muhammad , Li Yuan‐Yao , Su Yen‐Hsun , Clemens Oliver , Ting Jyh‐Ming 
Published: January 2024

AbstractTi, V, Cr, Mn, Co, and Cu, have been investigated as a third dopant in NiFe sulfide for enhanced oxygen evolution reaction (OER)/oxygen reduction reaction (ORR). The effects of dopant on surface electronic structure, conductivity, and thermodynamic barrier of reaction are addressed and discussed. For the OER, X‐ray photoelectron spectroscopy analysis shows that electron transferring from the Ni to the dopants enhances the catalytic performance of the sulfide. Cu doped NiFe sulfide exhibits the best OER performance. For the ORR, density functional theory calculation indicates that Ti, V, Mn, Co, and Cu upshift the d‐band center (ɛd), while Cr downshifts the ɛd. Among the dopants, V leads to optimized electronic structure modification, giving optimized adsorption energy of *O on the Ni, the lowest rate determining step ΔG1, and the best ORR activity. By considering E10‐E1/2 together with the maximum current density of the OER and limited diffusion current density of the ORR, NiFeVS exhibits the best OER/ORR bifunctionality. The performance of NiFeVS as a cathodic catalyst has also been evaluated in a zinc air battery, demonstrating a specific capacity of 698 mAh g−1, maximum power density of 190 mW cm−2, and a superior cycle stability of 2400 cycles (400 h).
Enabling High‐Performance Potassium‐Ion Batteries by Manipulating Interfacial Chemistry
Authors: Zhang Haodong , Wang Huwei , Li Wei , Wei Yaojie , Wen Bohua , Zhai Dengyun , Kang Feiyu 
Published: January 2024

AbstractAs a promising candidate for the flame‐retardant electrolyte, triethyl phosphate (TEP)/potassium bis(fluorosulfonyl)amide (KFSI)‐based electrolyte has drawn much attention in the K‐ion battery community. Although the TEP/KFSI formula at a moderate main salt concentration (normally, <3 m) enables the compatibility of the reactive K metal anode, the long‐standing oxidative instability of KFSI salt remains unsolved. Here, an additive strategy is reported to address the high‐voltage issue in the TEP/KFSI electrolyte, and generalize it to the other KFSI‐based electrolytes. The addition of potassium nitrate changes the surface charge distribution and effectively suppresses the decomposition of KFSI toward the high‐voltage cathode. The nitrate‐containing electrolyte enables superior stability of a 4.3 V‐class K‐ion battery, as evidenced by its 80% capacity retention over 2000 cycles (≈6 months) at the 1 C rate. Moreover, the long‐cycling stability of the graphite‐based full cell with Prussian Blue cathode is demonstrated.
2D Conductive Metal–Organic Framework with Anthraquinone Built‐In Active Sites as Cathode for Aqueous Zinc Ion Battery
Authors: Liu Jingjuan , Zhou Yi , Xing Guolong , Qi Meiling , Tang Zhe , Terasaki Osamu , Chen Long 
Published: January 2024

Abstract2D conductive metal–organic frameworks (2D c‐MOFs) as emerging 2D graphene‐like crystalline materials have become a promising platform for energy storage. However, their capacity is largely constrained by the limited number of electroactive sites. Integrating multiple redox‐active moieties into the 2D c‐MOF skeletons is an efficient strategy toward high‐performance battery cathodes. Herein, by tailoring an anthraquinone‐based multitopic catechol ligand, a novel quinone‐containing copper‐catecholate MOF (Cu‐TBPQ MOF) is successfully developed. The Cu‐TBPQ MOF exhibits abundant porosity, excellent conductivity, and multiple redox‐active sites. These characteristics make it an ideal candidate as a cathode material for zinc ion batteries. Notably, the Cu‐TBPQ MOF demonstrates an impressive reversible specific capacity of 371.2 mAh g−1 at a current density of 50 mA g−1. Furthermore, it exhibits outstanding rate capability and long‐term durability, retaining a capacity of 120.3 mAh g−1 at a high current density of 2.0 A g−1 even after 500 charge–discharge cycles. The successful enrichment of redox‐active sites in the work opens up new avenues for the rational design of electrochemically active 2D c‐MOFs, enhancing their potential for advanced energy storage applications.
Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity
Authors: Pan Qiyuan , Zheng Yi , Zhou Yang , Zhang Xiao , Yuan Meng , Guo Jingying , Xu Chao , Cheng Ziyong , Kheraif Abdulaziz A. Al , Liu Min , Lin Jun 
Published: January 2024

AbstractRescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO3/TiO2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing Al3+ ions into the inorganic sonosensitive SrTiO3/TiO2 heterojunction induces oxygen vacancies and disrupts the lattice of SrTiO3. By overcoming the bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive oxygen species (ROS). In the sonodynamic therapy (SDT) process, stimulus on Al‐STNT induces abundant ROS efficiently disrupting the bacteria biofilm and inhibiting biofilm metabolism. Moreover, the specific nanoscale SrTiO3 coating endows dental implants with osteogenic activity, facilitating the formation of rigid osseointegration between the implant surface and alveolar bone. By mimicking human dental implants in rats, Al‐STNT demonstrates optimal postimplant osseointegration while retaining its antibacterial ability as a sonosensitizer. Thanks to the portability of the ultrasound instrument and the stability of implant‐based sonosensitizer, this strategy presents an attractive option for patients to self‐treat and secure the long‐term success of their implants.
A Configuration Entropy Enabled High‐Performance Polyanionic Cathode for Sodium‐Ion Batteries
Authors: Li Meng , Sun Chen , Yuan Xuanyi , Li Yang , Yuan Yifei , Jin Haibo , Lu Jun , Zhao Yongjie 
Published: January 2024

AbstractPolyanionic sodium ion cathodes have attracted lots of concern because of their excellent structural stability. However, the low specific capacity is still a pressing issue hampering their practical application. In this work, a medium‐entropy NASICON‐structure cathode Na3.5V0.5Mn0.5Fe0.5Ti0.5(PO4)3 (Me‐NVMP) is proposed. The Me‐NVMP achieves a highly reversible specific capacity of 165.8 mAh g−1 (1.8–4.4 V vs Na+/Na) at 0.1 C via the stepwise redox reactions of Ti3+/Ti4+‐Fe2+/Fe3+, V3+/V4+‐Mn2+/Mn3+, and V4+/V5+‐Mn3+/Mn4+. More impressively, the Me‐NVMP yields super rate capability and cycling stability via the regulation of configuration entropy in NASICON. Specifically, the Me‐NVMP cathode can preserve a capacity retention of 83.5% after 10,000 cycles at 100 C (17 A g−1). Furthermore, excellent cycling performance even at the temperature of 0 °C (capacity retention of 93.45% at 20 C after 1000 cycles) is also demonstrated. In situ X‐ray diffraction analysis reveals that the enhanced performance can be mainly attributed to the solid–solution‐type Na+ storage behavior in Me‐NVMP. Moreover, issues such as Jahn‐Teller distortion of Mn3+ and irreversible structural change at high voltage (>4.0 V vs Na+/Na) are effectively mitigated. This work inspires a new strategy to design high‐performance polyanionic electrode materials.
Borophene Based 3D Extrusion Printed Nanocomposite Hydrogel for Antibacterial and Controlled Release Application
Authors: Das Poushali , Ganguly Sayan , Marvi Parham Khoshbakht , Sherazee Masoomeh , Ahmed Syed Rahin , Tang Xiaowu (Shirley) , Srinivasan Seshasai , Rajabzadeh Amin Reza 
Published: January 2024

AbstractHerein, a borophene/zinc oxide (BZ) nanocomposite is synthesized through a straightforward one‐step solvothermal process, avoiding the need for any rigorous reducing agent. The BZ nanocomposites are introduced into semi‐interpenetrating polymer networks to form hydrogels via in situ UV triggered free radical gelation during three‐dimensional (3D) microextrusion printing. The hydrogels exhibit mechanical robustness, high compressibility, pH sensitivity, and microporosity. The diffusion behavior of the hydrogel shows a combination of swelling and molecular chain relaxation based on its water uptake kinetics. Hydrogels are tested in rigorous pH environments over multiple cycles to ensure structural integrity. The rheological assessment of the hydrogels proves their high elasticity. The uniaxial mechanical properties support its mechanical toughness and zero permanent set resulting elastomeric soft matrix. The cyclic compression test up to 100 cycles has negligible data deviations in calculating compression moduli (≈24 kPa). The hydrogels are non‐toxic and found to be effective bactericidal materials for both Gram‐positive and Gram‐negative bacteria. The hydrogel demonstrates pH‐responsive time‐dependent payload release behavior, suggesting its potential as a soft matrix drug carrier in biomedical research. To the best of the authors knowledge, this is the first report of BZ‐based soft biomaterial with antibacterial properties serving as an excellent controlled drug delivery device.
Tunable Ionic Sieving Membrane via Reactive Layer‐By‐Layer Assembly of Porous Organic Cages
Authors: Zhang Yu , Hao Zhan , Hussein Ismail , Wang Zhi , Zhao Song 
Published: January 2024

AbstractSelectively permeable membranes with subnanosized pores show potential for applications in saline wastewater treatment and resource recovery. Here, a novel ionic sieving membrane (ISM) is fabricated via reactive layer‐by‐layer assembly of reduced porous organic cages, providing confined pores for the entry of monovalent ions and the interception of divalent ions. The ion separation performance of ISMs can be tuned by varying the concentration of reduced porous organic cages during the assembly. The highly permeable ISM featuring a surface potential of −52 mV and widely distributed aperture (µp = 0.69 nm, σp = 1.37) preferentially permits the passage of Cl− over SO42−, resulting in remarkable permeance of 9.4 L m−2 h−1 bar−1 and Cl−/SO42− selectivity of 50.3. However, the highly selective ISM with a surface potential of −30 mV and narrowly distributed aperture (µp = 0.66 nm, σp = 1.27) exhibits superior Cl−/SO42− selectivity of 277.3 and Li+/Mg2+ selectivity of 64.7, indicating that the regular subnanosized pore structure plays a dominant role in achieving precise separation of mono‐/divalent ions. Moreover, owing to the acquired excellent Li+/Mg2+ selectivity, for the first time, lithium extraction from simulated salt lake brine is achieved by a two‐stage nanofiltration process with reduced Mg2+/Li+ mass ratio from 40 to 0.3.
Revealing the Active Sites in Atomically Dispersed Multi‐Metal–Nitrogen–Carbon Catalysts
Authors: Sun Buwei , Zhang Shiyu , Yang Haozhou , Zhang Tianyu , Dong Qiujiang , Zhang Wanxing , Ding Jia , Liu Xiaogang , Wang Lei , Han Xiaopeng , Hu Wenbin 
Published: January 2024

AbstractAtomically dispersed metal‐nitrogen‐carbon catalysts have been extensively explored for various sustainable energy‐related reactions. From a material perspective, these catalysts are likely to consist of a combination of single‐atom, dual‐atom and possibly even multi‐atom sites. However, pinpointing their true active sites has remained a challenging task. In this study, a model catalyst is introduced, Co/CoMn‐NC, featuring both Co single‐atom sites and CoMn dual‐atom sites on a nitrogen‐doped carbon substrate. By employing a combination of X‐ray adsorption spectroscopy and density functional theory calculations, the atomic configuration of Co/CoMn‐NC has been determined. Density functional theory calculations are also used to unequivocally identify Co‐atom within the CoMn dual‐atom motif as the predominate active site of the Co/CoMn‐NC model catalyst toward oxygen reduction reaction (ORR), which is further confirmed by in situ Raman spectroscopy. The cooperative interactions between Co single‐atom sites and CoMn dual‐atom sites can finely tune the d‐band center and ameliorate the adsorption and desorption behaviors of the intermediates, thereby facilitating ORR kinetic. Overall, the study introduces a systematic strategy to elucidate the structure and the superiority of the model system and provides new insights into atomically dispersed multi‐metal active sites, showcasing that enhanced catalytic performance extends beyond unified diatomic sites or monatomic sites.
Radiotherapy Resistance of 3D Bioprinted Glioma via ITGA2/p‐AKT Signaling Pathway
Authors: Liu Dongdong , Tian Haotian , Li Huaixu , Nie Jianyu , Han Zhenyu , Tang Guozhang , Gao Peng , Cheng Hongwei , Dai Xingliang 
Published: January 2024

AbstractDue to the inherent radiation tolerance, patients who suffered from glioma frequently encounter tumor recurrence and malignant progression within the radiation target area, ultimately succumbing to treatment ineffectiveness. The precise mechanism underlying radiation tolerance remains elusive due to the dearth of in vitro models and the limitations associated with animal models. Therefore, a bioprinted glioma model is engineered, characterized the phenotypic traits in vitro, and the radiation tolerance compared to 2D ones when subjected to X‐ray radiation is assessed. By comparing the differential gene expression profiles between the 2D and 3D glioma model, identify functional genes, and analyze distinctions in gene expression patterns. Results showed that 3D glioma models exhibited substantial alterations in the expression of genes associated with the stromal microenvironment, notably a significant increase in the radiation tolerance gene ITGA2 (integrin subunit A2). In 3D glioma models, the knockdown of ITGA2 via shRNA resulted in reduced radiation tolerance in glioma cells and concomitant inhibition of the p‐AKT pathway. Overall, 3D bioprinted glioma model faithfully recapitulates the in vivo tumor microenvironment (TME) and exhibits enhanced resistance to radiation, mediated through the ITGA2/p‐AKT pathway. This model represents a superior in vitro platform for investigating glioma radiotherapy tolerance.