bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of the “Pocket Monster” Incident on Patients with Convulsive Disorders
Authors: Murakami Nagako , Enoki Hideo , Minakuchi Eita , Akiyama Tomoyuki , Hattori Junri , Oka Eiji 
Published: August 2005

Purpose: A number of people were reported to have suffered such acute symptoms as convulsions, impairment of consciousness, head‐ache, and vomiting while watching the animated TV program “Pocket Monster”on December 16, 1997. A questionnaire survey was conducted to determine the effect of watching this TV show on people with convulsive disorders. Methods: Subjects were patients at the Department of Child Neurology, Okayama University Hospital, who were diagnosed as having epilepsy, febrile convulsion, or latent epilepsy. A questionnaire was sent to all patients (n = 1,533) between the ages of 3 and 25 living in Okayama Prefecture on December 31, 1997. The questionnaire was designed to ascertain the following information: the past history of convulsions in the patient and family members; whether the patient had watched the TV show; whether symptoms had subsequently appeared; the TV viewing environment; and a detailed description of the symptoms. Results: (I) Of the 1,533 patients who were sent a questionnaire, 9 18 (59.9%) returned it. The results of the survey revealed that 342 (37.3%) of the 918 patients had been watching the show, with 18 (5.3%) of these 342 showing some type of symptom. (2) Children in elementary school represented the majority of viewers, with the second largest group being toddlers. The age distribution of the 18 patients ranged as following: 3 patients (4.1 %) were under 7 years of age; 1 I patients (5.7%) were between 7 and 12; 3 patients (7.3%) were between 13 and 15; and 1 patient (5.0%) was between 16 and 18. (3) The incidence rate of induced symptoms among the different types of epilepsy was as follows: 7.7% in febrile convulsion, 4.5% in localization related epilepsy, 14.2% in generalized epilepsy, and 0% in latent epilepsy. (4) Only I patient had a generalized tonic‐clonic seizure, and the remaining 17 patients did not have any convulsion but had autonomic symptoms such as headache, visual symptoms, discomfort, or vomiting. Two patients had eyelid myoclonus. (5) Eleven patients (3.2%) of 342 cases had past histories of photosensitive seizures, and 4four patients (1.2%) of 342 cases had past histories of photoparoxysmal responses on EEG (PPR). “Pocket Monster” animation‐induced symptoms were noted in 2 of the I I patients with a past history of photosensitive seizures and 1 of the 4 patients with PPR. (6) Intermittent photic stimulation (IPS) was performed on 10 of 18 patients with animation induced symptoms. PPR did not appear in 8 (88.9%) of 9 patients who had animation induced autonomic symptoms. Conclusion: “Pocket Monster” animation induced paroxysmal symptoms i n 5.3% of the patients with epilepsy, febrile convulsions, or latent epilepsy. The incidence rate in the patients was lower than that (7.1%)
The Effect of Ethyl Loflazepate on Refractory Childhood Epilepsy
Authors: Murakemi Nagako , Yoshinaga Harumi , Ohmori Iori , Ogawa Kazunori , Asano Takashi , Oka Eiji 
Published: August 2005

Purpose: A clinical and electroencephalographic study was performed to evaluate the effect of ethyl loflazepate (LOF) on patients with childhood refractory epilepsy. Methods: We investigated the effect of LOF add‐on therapy (0.1–4.0 mg/day, 0.003–0.374 mg/kg/day) on clinical seizures and EEGs as well as side effects in 39 patients, ranging in age from 3 months to 23 years, with 33 of the 39 being under IS years of age. The study population consisted of I3 patients with symptomatic localization‐related epilepsy: frontal lobe epilepsy in 4, temporal lobe epilepsy in I, other types i n 8; 22 with symptomatic generalized epilepsy: Ohtahara syndrome in 1, West syndrome in 6, Lennox‐Gastaut syndrome in 9, other types in 6; and 4 with undetermined epilepsy: severe myoclonic epilepsy in infancy in 1, epilepsy with continuous spike‐wave during slow wave sleep in, and other types in I. The patients underwent the LOF treatment for >3 months (maximum, 2 years and 1 month). Results: (I) LOF had marked effect (complete suppression or >75% reduction of seizures) in 8 cases and moderate effect (50%‐74% reduction of seizures) in 5 cases. Transient benefit for <1 month was observed in I I cases. The remaining 15 cases showed no effect. (2) Marked or moderate effects were found in 18 (72.8%) of 22 cases with symptomatic generalized epilepsy (long‐lasting effects in 8 and only a transient initial effect i n lo), in 3 (23. I%) of 13 cases with symptomatic localization‐related epilepsy, and in 2 (50%) of 4 cases with undetermined epilepsy. (3) Types of seizure in effective (marked or moderate) cases consisted of spasms in 8, tonic seizures in 2, and complex partial seizures in 3 cases. (4) EEG findings in 13 effective cases showed that a decrease in epileptic discharge was seen i n 5 cases with no change in the remaining 8. (5) The correlation between maximum dosage and blood concentration level was investigated in each patient, and the results confirmed a significant correlation (R= 0.691). However, no significant correlation was observed between maximum dose per body weight (kg) and effectiveness. (6) Side‐effects such as sleepiness, hypersalivation, hypotonia, hyperexcitability, and restlessness were observed i n 20 (5 1.3%) patients. In I patient, the drug administration was discontinued due to drug‐induced microseizures during sleep. Conclusion: LOF is an effective drug for symptomatic generalized epilepsy in children who show spasms, although a significant number of cases showed tolerance and only a transient initial effect.
User research as kool-aid
Authors: Arnowitz Jonathan , Dykstra-Erickson Elizabeth 
Published: August 2005

drink the Kool-Aid,
v. To become a firm believer in something; to accept an argument or philosophy wholeheartedly or blindly.

This phrase stems from the 1978 "Jonestown massacre" in which members of the Peoples Temple cult committed suicide by drinking cyanide-laced Kool-Aid (although some say the drink of choice was actually Flav-R-Aid) [1].
Designers don't hurt people; designs do
Authors: Anderson Douglas W. 
Published: August 2005

How many people do you know who have physical problems they attribute to computer use? (I wear wrist braces at night myself, so that my mild carpal-tunnel syndrome doesn't bother me much during the day.) Many of us seem to have the impression that such problems arise mainly from poor hardware design... or perhaps from an overindulgence in gaming, with its incessant, repetitive arm/wrist/hand/finger movements.
But is it that simple? In this Whiteboard column, Doug Anderson points out how interaction design and usability efforts can overlook such problems, and urges us to pay more attention to them. I would add one more suggestion to his list of ideas: Even when longitudinal usability testing is not feasible, we can monitor our applications and systems in long-term use and note any physical problems that tend to appear among our users.
---Elizabeth Buie
Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways
Authors: Salameh Ahmad , Galvagni Federico , Bardelli Monia , Bussolino Federico , Oliviero Salvatore 
Published: August 2005

AbstractVascular endothelial growth factor receptor-3 (VEGFR-3) plays a key role for the remodeling of the primary capillary plexus in the embryo and contributes to angiogenesis and lymphangiogenesis in the adult. However, VEGFR-3 signal transduction pathways remain to be elucidated. Here we investigated VEGFR-3 signaling in primary human umbilical vein endothelial cells (HUVECs) by the systematic mutation of the tyrosine residues potentially involved in VEGFR-3 signaling and identified the tyrosines critical for its function. Y1068 was shown to be essential for the kinase activity of the receptor. Y1063 signals the receptor-mediated survival by recruiting CRKI/II to the activated receptor, inducing a signaling cascade that, via mitogen-activated protein kinase kinase-4 (MKK4), activates c-Jun N-terminal kinase-1/2 (JNK1/2). Inhibition of JNK1/2 function either by specific peptide inhibitor JNKI1 or by RNA interference (RNAi) demonstrated that activation of JNK1/2 is required for a VEGFR-3–dependent prosurvival signaling. Y1230/Y1231 contributes, together with Y1337, to proliferation, migration, and survival of endothelial cells. Phospho-Y1230/Y1231 directly recruits growth factor receptor–bonus protein (GRB2) to the receptor, inducing the activation of both AKT and extracellular signal–related kinase 1/2 (ERK1/2) signaling. Finally, we observed that Y1063 and Y1230/Y1231 signaling converge to induce c-JUN expression, and RNAi experiments demonstrated that c-JUN is required for growth factor–induced prosurvival signaling in primary endothelial cells.
How Infants Encode Spatial Extent
Authors: Duffy Sean , Huttenlocher Janellen , Levine Susan , Duffy Renee 
Published: August 2005

AbstractThis study explores how infants encode an object's spatial extent. We habituated 6.5‐month‐old infants to a dowel inside a container and then tested whether they dishabituate to a change in absolute size when the relation between dowel and container is held constant (by altering the size of both container and dowel) and when the relation changes (by altering only the size of the container but not the dowel). Infants only dishabituated when the relation changed, suggesting that they do not encode the absolute size of either object but only the relation between them.
Vision Impairment and Psychosocial Function in US Adults
Authors: Almidani Louay , Miller Rhonda , Varadaraj Varshini , Mihailovic Aleksandra , Swenor Bonnielin K. , Ramulu Pradeep Y. 
Published: February 2024

ImportanceVision impairment and psychosocial function, including symptoms of depression and anxiety and social isolation, are a major cause of morbidity in the US. However, there is a lack of nationally representative studies assessing associations between both objective and subjective vision impairment with psychosocial function following the COVID-19 pandemic.ObjectiveTo provide updated national estimates on the associations of vision impairment with depressive and anxiety symptoms and social isolation in US adults 65 years and older.Design, Setting, and ParticipantsThis was a cross-sectional analysis of the National Health and Aging Trends Study round 9 (2019) and 11 (2021), a nationally representative sample of Medicare beneficiaries aged 65 years and older. Binocular distance visual acuity, near visual acuity, and contrast sensitivity were tested. Objectively measured vision impairment was defined as having vision impairment in either distance visual acuity (worse than 20/40), near visual acuity (worse than 20/40), or contrast sensitivity (worse than 1.55 logCS). Self-reported vision impairment was defined based on participants’ report on their vision status. Data were analyzed in May 2023.Main Outcomes and MeasuresDepressive and anxiety symptoms assessed via the Patient Health Questionnaire. Social isolation was defined based on living arrangement, communication frequency, and activity participation responses.ResultsAmong 2822 community-dwelling adults sampled from a population of 26 182 090, the mean (SD) age was 78.5 (5.6) years; 1605 individuals (54.7%) were female; 1077 (32.3%) had objectively measured vision impairment, and 203 (6.4%) had self-reported vision impairment. In adjusted models, all outcomes were significantly associated with objectively measured vision impairment, including depressive symptoms (odds ratio [OR], 1.81; 95% CI, 1.26-2.58), anxiety symptoms (OR, 1.74; 95% CI, 1.13-2.67), and severe social isolation (OR, 2.01; 95% CI, 1.05-3.87). Similarly, depressive symptoms (OR, 2.37; 95% CI, 1.44-3.88) and anxiety symptoms (OR, 2.10; 95% CI, 1.09-4.05) but not severe social isolation symptoms (OR, 2.07; 95% CI, 0.78-5.49) were significantly associated with self-reported vision impairment.Conclusions and RelevanceIn this study, vision impairment was associated with several psychosocial outcomes, including symptoms of depression and anxiety and social isolation. These findings provide evidence to support prioritizing research aimed at enhancing the health and inclusion of people with vision impairment.
Ultrasonic‐Assisted Processing Combined with Gas Quenching for Fabricating High‐Performance and Stable Inverted Perovskite Solar Cells
Authors: Chen Jiujiang , Liu Jian , Li Yifei , Xu Peng , Xie Lisha , Meng Yuanyuan , Wu Haodong , Shang Xiaofeng , Zhao Su , Pan Jun , Xiao Chuanxiao , Yang Mengjin , Ge Ziyi 
Published: February 2024

AbstractIn recent years, perovskite solar cells have attained unprecedented advancements in power conversion efficiency, yet their commercialization remains a formidable challenge. Addressing this challenge relies on developing an affordable and scalable method for manufacturing top‐notch perovskite films. This study presents an innovative strategy, employing both gas quenching technology and ultrasonic‐assisted processing (UAP), to fabricate high‐caliber perovskite thin films. The UAP process enhances the grain size of the perovskite film, reduces grain boundary defects, improves carrier extraction and transport, and suppresses carrier nonradiative recombination. Furthermore, it effectively reduces residual stress and mitigates lattice distortion in the perovskite crystals. Ultimately, efficient and stable inverted perovskite solar cells using FA0.87Cs0.13PbI2.7Br0.3 and FA0.85MA0.1Cs0.05PbI3 perovskite are successfully prepared. The target device achieved a power conversion efficiency of 22.32% and 24.51%, respectively. Moreover, the target devices exhibited enhanced photostability. This work provides a cost‐effective and scalable method for producing high‐quality perovskite films, paving the way for the commercialization of perovskite solar cells.
Amphoteric Polymer Strategy with Buffer‐Adsorption Mechanism for Long‐Life Aqueous Zinc Ion Batteries
Authors: Huang Chenyue , Mao Jiale , Li Siyuan , Zhang Weidong , Wang Xinyang , Shen Zeyu , Zhang Shichao , Guo Junze , Xu Yunkai , Lu Yingying , Lu Jun 
Published: February 2024

AbstractWater‐based secondary batteries with multivalent metals anode provide a promising option for energy storage with low cost and high security. However, the electrochemical performance of aqueous Zinc ion batteries (AZIBs) is mainly restricted by problems such as poor reversibility and hydrogen evolution. Herein, an “amphoteric polymer strategy” with buffer‐adsorption mechanism for AZIBs is proposed by introducing poly‐L‐Glutamic Acid (PGA) into the electrolyte. Amphoteric polymer enriched functional carboxyl and amino groups confer high compatibility of the Zn metal anodes as well as the relative stability of the bulk electrolyte pH simultaneously. Partial PGA molecules distributed in bulk electrolyte dynamically dissociate to stabilize pH and correspondingly slow down the generation of inert components, while others specifically adsorbed on zinc foil can relieve electrochemical corrosion and induce dendrite‐free uniform Zn deposition. Consequently, long‐term cycling stability (>1650 h) and high levels of reversibility (Coulombic efficiency>99.5%) of Zn anode are harvested in 2 m ZnSO4 electrolyte with only 0.5 wt% of PGA. In addition, when coupled with Zn0.25V2O5(ZVO) cathode, the full cell exhibits higher capacity retention and less pH fluctuation. This work reveals a novel buffer‐adsorption mechanism offered by amphoteric functional polymer, and provides a new additive design principle for rechargeable AZIBs.
Interfacial Solar Evaporation: From Fundamental Research to Applications
Authors: Wu Xuan , Lu Yi , Ren Xiaohu , Wu Pan , Chu Dewei , Yang Xiaofei , Xu Haolan 
Published: February 2024

AbstractIn the last decade, interfacial solar steam generation (ISSG), powered by natural sunlight garnered significant attention due to its great potential for low‐cost and environmentally friendly clean water production in alignment with the global decarbonization efforts. This review aims to share the knowledge and engage with a broader readership about the current progress of ISSG technology and the facing challenges to promote further advancements toward practical applications. The first part of this review assesses the current strategies for enhancing the energy efficiency of ISSG systems, including optimizing light absorption, reducing energy losses, harvesting additional energy, and lowering evaporation enthalpy. Subsequently, the current challenges faced by ISSG technologies, notably salt accumulation and bio‐fouling issues in practical applications, are elucidated and contemporary methods are discussed to overcome these challenges. In the end, potential applications of ISSG, ranging from initial seawater desalination and industrial wastewater purification to power generation, sterilization, soil remediation, and innovative concept of solar sea farm, are introduced, highlighting the promising potential of ISSG technology in contributing to sustainable and environmentally conscious practices. Based on the review and in‐depth understanding of these aspects, the future research focuses are proposed to address potential issues in both fundamental research and practical applications.
Spatiotemporal Insights into Glioma Oncostream Dynamics: Unraveling Formation, Stability, and Disassembly Pathways
Authors: Faisal Syed M. , Clewner Jarred E. , Stack Brooklyn , Varela Maria L. , Comba Andrea , Abbud Grace , Motsch Sebastien , Castro Maria G. , Lowenstein Pedro R. 
Published: February 2024

AbstractGlioblastoma (GBM) remains a challenge in Neuro‐oncology, with a poor prognosis showing only a 5% survival rate beyond two years. This is primarily due to its aggressiveness and intra‐tumoral heterogeneity, which limits complete surgical resection and reduces the efficacy of existing treatments. The existence of oncostreams—neuropathological structures comprising aligned spindle‐like cells from both tumor and non‐tumor origins‐ is discovered earlier. Oncostreams are closely linked to glioma aggressiveness and facilitate the spread into adjacent healthy brain tissue. A unique molecular signature intrinsic to oncostreams, with overexpression of key genes (i.e., COL1A1, ACTA2) that drive the tumor's mesenchymal transition and malignancy is also identified. Pre‐clinical studies on genetically engineered mouse models demonstrated that COL1A1 inhibition disrupts oncostreams, modifies TME, reduces mesenchymal gene expression, and extends survival. An in vitro model using GFP+ NPA cells to investigate how various treatments affect oncostream dynamics is developed. Analysis showed that factors such as cell density, morphology, neurotransmitter agonists, calcium chelators, and cytoskeleton‐targeting drugs influence oncostream formation. This data illuminate the patterns of glioma migration and suggest anti‐invasion strategies that can improve GBM patient outcomes when combined with traditional therapies. This work highlights the potential of targeting oncostreams to control glioma invasion and enhance treatment efficacy.
Preparation of Distant Quantum Entanglement and One‐way Quantum Steering in Hybrid Cavity‐Magnonics‐and‐Cavity‐Optomechanical Systems
Authors: Wan Qin‐Min , Lin Yue‐Han , Lin Ya‐Qin , Cong Long‐Jiang , Yang Rong‐Can , Liu Hong‐Yu 
Published: February 2024

AbstractA hybrid system that combines cavity magnonics and cavity optomechanics is proposed to facilitate the generation of long‐distance entanglement and enable one‐way steering between magnons and phonons. This configuration involves two directly coupled cavities, with one interacting with magnons and the other coupling with a mechanical oscillator (i.e., phonons). By driving the microwave cavity with a weak squeezed vacuum field generated by a flux‐driven Josephson parametric amplifier, entanglement and one‐way steering can be further enhanced. Moreover, the results demonstrate that magnon–phonon entanglement and one‐way quantum steering exhibit robustness against temperature variations, which has significant implications for quantum information processing and storage.
Advanced Functionalized Nanoclusters (Cu, Ag, and Au) as Effective Catalyst for Organic Transformation Reactions
Authors: Kumar Parveen , Nemiwal Meena 
Published: February 2024

AbstractA considerable amount of research has been carried out in recent years on synthesizing metal nanoclusters (NCs), which have wide applications in the field of optical materials with non‐linear properties, bio‐sensing, and catalysis. Aside from being structurally accurate, the atomically precise NCs possess well‐defined compositions due to significant tailoring, both at the surface and the core, for certain functionalities. To illustrate the importance of atomically precise metal NCs for catalytic processes, this review emphasizes 1) the recent work on Cu, Ag, and Au NCs with their synthesis, 2) the parameters affecting the activity and selectivity of NCs catalysis, and 3) the discussion on the catalytic potential of these metal NCs. Additionally, metal NCs will facilitate the design of extremely active and selective catalysts for significant reactions by elucidating catalytic mechanisms at the atomic and molecular levels. Future advancements in the science of catalysis are expected to come from the potential to design NCs catalysts at the atomic level.
Modellbasierte Entwicklung und Umsetzung der digitalen Bauwerksakte
Authors: Hindersmann Iris , Haferkamp David , Probst Rebecca , Krenz Lisa‐Marie , Nieborowski Sonja , Bednorz Jennifer 
Published: February 2024

AbstractDer Einsatz von BIM im Brückenbau ist aktuell noch überwiegend auf die Phasen Planen und Bauen beschränkt, aber insbesondere für den Betrieb von Bauwerken kann BIM einen großen Mehrwert erzielen. Grundlage für die Anwendung der BIM‐Methode in der Lebenszyklusphase Betrieb ist die Überleitung der relevanten Informationen aus den Lebenszyklusphasen Planen und Bauen in die Lebenszyklusphase Betrieb. Die Erstellung einer modellbasierten digitalen Bauwerksakte während der Leistungsphase 8 ermöglicht die digitale Übergabe und Weiterverwendung der relevanten Informationen für den Betrieb. Der Beitrag ordnet die Erstellung und Nutzung modellbasierter digitaler Bauwerksakten sowohl in den wissenschaftlichen Kontext als auch in die aktuelle Arbeitsmethode mit analoger Schlussrechnungs‐ und Bauwerksakte ein. Darüber hinaus beinhaltet er die praktische Umsetzung an einem konkreten Projekt. Weiterhin wird der Bezug zu den standardisierten Anwendungsfällen 190 „Projekt‐ und Bauwerksdokumentation“ und 200 „Nutzung für Betrieb und Erhaltung“ dargestellt. Die Umsetzung der modellbasierten digitalen Bauwerksakte wird am Beispiel des Autobahndreiecks Köln‐Heumar demonstriert. Hierbei wird auf die Ziele und Grundlagen, welche mit dem Einsatz von BIM verbunden sind, die Projektentwicklung und die Hintergründe eingangen. Die Umsetzung und Übergabe der modellbasierten digitalen Bauwerksakte wird für das Praxisbeispiel umfangreich beschrieben.
Sub‐1 nm Nanomaterials Applied in Energy Storage
Authors: Yuan Guobao , Liu Junli , Zhang Yu 
Published: February 2024

AbstractSub‐1 nm nanomaterials (SNMs) present rapid electrons/ions transport and unique polymer‐analogue properties due to their ultrahigh specific surface area and nearly 100 % surface atomic exposure, which are very promising in the application of energy storage devices. However, there still lack of relative review about the SNMs applied in energy storage until now. This review focuses on the structural advantages of SNMs and their synthesis methods, and then discusses latest advances of employing SNMs for advanced battery systems. The superior functions of SNMs are emphasized for designing every single component in batteries, including electrode materials, separators and electrolytes, greatly improving the performance of batteries. Finally, the current challenges and future research directions of SNMs are proposed, aiming to provide a new insight into the design and manufacture of SNMs for the further development of high‐performance energy storage devices.