bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L
Authors: Ranathunga Lakmal , Abesinghe Sachini , Cha Ji-Won , Dodantenna Niranjan , Chathuranga Kiramage , Weerawardhana Asela , Haluwana D. K. , Gamage Nuwan , Lee Jong-Soo 
Published: February 2025

Abstract
African swine fever virus (ASFV) is nucleocytoplasmic large DNA arbovirus and encodes many proteins involved in the interaction with host molecules to evade antiviral immune responses. Especially, evasion strategies of type I interferon (IFN-I)-mediated immune responses are crucial for early ASFV replication. However, there is still a lack of information regarding the immune evasion mechanism of ASFV proteins. Here, we demonstrated that ASFV DP71L suppresses STING-mediated antiviral responses. The conserved phosphatase 1 (PP1) motif of DP71L specifically interact with the C-terminal tail (CTT) of STING and in particular, amino acids P371, L374, and R375 of STING were important for interaction with DP71L. Consequently, this interaction disrupted the binding between STING and TANK-binding kinase 1 (TBK1), thereby inhibiting downstream signaling including phosphorylation of TBK1, STING and IRF3 for antiviral signaling. DP71L significantly interfered with viral DNA induced interferon production and IFN-mediated downstream signaling in vitro. Consistently, knockdown of DP71L enhanced antiviral gene expression in ASFV-infected cells. Taken together, these results highlight the important role of DP71L with respect to inhibition of interferon responses and provide guidance for a better understanding of ASFV pathogenesis and the development of live attenuated ASFV vaccines.
The geographical variation in grassland forage quality on the eastern Qinghai-Tibet Plateau is driven mainly by climate
Authors: Wu Shulan , Lü Xiaotao , Liu Qinghua , Wuda Erke , Li Liu , Zhao Chunzhang , Huang Juanjuan , Li Shuang , Hu Youbang , Du Wenzhi , Li Hewen , Chen Chaoqun , Luo Lin , Raza Ali , Yin Chunying 
Published: February 2025

Abstract

Background
Forage quality is a fundamental determinant for livestock productivity in natural grasslands, and is sensitive to the variations in climate, soil, and plant community composition. However, the contributions of those factors to the regional variation of forage quality largely remain unclear. We examined forage quality of 45 alpine meadow communities over a 23.6 × 104 km2 area on the eastern Qinghai-Tibet Plateau in China. We also examined the variations and drivers of multiple forage quality indicators across regional scale.

Results
The results showed that the natural grasslands in this region had high crude protein and non-fiber carbohydrates content, and relative feed value, but low-fat content. Forage quality of forb-dominated grasslands was higher than grass- and sedge-dominated ones. There were substantial geographical variations of forage quality, which decreased with increasing longitude, and increased with increasing latitude and altitude. Climate and plant community composition directly controlled the geographical patterns of forage quality. Climate had larger contribution to forage quality than soil and plant community composition. Less sedge and more forb in community resulted in higher forage quality. Forage quality was higher in sites with colder, drier and more variable climate. Soil conditions indirectly affected forage quality by mediating the plant community composition.

Conclusions
This study highlights the role of climate in driving the variation of forage quality in the alpine grasslands. The findings could provide scientific supports for grassland management and sustainable development on the Qinghai-Tibet Plateau.
The impact of Sudan armed conflict and coping strategies on the mental health of the older adult internally displaced persons in Darfur camps
Authors: Musa Saif A. , Hamid Abdalla A. R. M. 
Published: February 2025

Abstract

Background
The war victims in Darfur witnessed the killing of relatives, rape of women, and loss of property. Studies in war-affected populations have reported high rates of mental health problems. The present study aimed at investigating the effects of the armed conflict in Sudan on the mental health of the older adult IDPs in Darfur as well as the role of coping strategies in dealing with psychological distress.

Methods
A purposive sampling technique was used to select 109 older adult internally displaced persons (Mage = 74.93; SD = 7.07). The General Health Questionnaire (GHQ 28), the Coping Inventory for Stressful Situations (CISS), and a demographic survey were used to collect data.

Results
The results revealed a high prevalence (75.2%) of non-psychotic psychiatric disorders amongst the older adult IDP participants. Task-focused coping was negatively related to somatic symptoms (p < 0.01), anxiety (p < 0.05), and general distress (p < 0.01), while avoidance was negatively related to age (p < 0.05) and social dysfunction (p < 0.05). Family size was positively associated with task-focused coping (p < 0.05) and negatively associated with somatic symptoms (p < 0.05). The results further showed significant gender differences in somatic symptoms (p < 0.001), anxiety (p < 0.05), general distress (p < 0.01), task-focused (p < 0.001) and avoidance coping (p < 0.05).

Conclusion
The findings of this study suggest that attention should be directed towards fostering positive coping capacity and the provision of psychosocial support services for older adult IDPs in Darfur.
Methane hydrate systems off South Makassar Basin, Indonesia
Authors: Dirgantara Feisal , Susilohadi Susilohadi , Iskandar Mohammad Andri Syahrir , Sintuwardhana Yudha Arisandhy 
Published: February 2025

Abstract
Previous drilling and coring efforts have confirmed the presence of methane hydrates in the deepwater Makassar Strait of Indonesia. The strait, separated into the North Makassar Basin and South Makassar Basin, is situated on the thinned Eurasian continental crust that began to rift during the Middle Eocene. While past methane hydrates studies have focused on the northern basin, the southern region lacks equivalent investigation. This research employs legacy multi-channel seismic reflection and well logs data to decipher the methane hydrate systems and associated free methane in the South Makassar Basin. Identified through the interpretation of bottom simulating reflectors (BSRs), seafloor topography, and structural features on seismic reflection profiles are five primary play types: polygonal faults type, slope type, buried fold type, buried carbonate mound type, and sediment waves type. The distinctive characteristics of BSRs in this region can be summarized as follows: (1) predominantly located beneath topographic highs and basin depocenter, (2) typically displaying a series of high-amplitude dipping reflectors beneath BSRs, (3) the distribution of BSRs is not always continuous and is not always parallel to that of the seafloor, and (4) the presence of blanking reflection above BSRs is variable. These features suggest methane hydrate accumulation preferentially occurs beneath structural highs and in basin depocenters, likely due to the upward and lateral migration of buoyant, methane-rich fluids. Through the analysis of seismic amplitude distribution and reflection strength in relation to BSR depth, hydrocarbon distribution is categorized into methane-hydrate reservoirs above BSRs and free methane reservoirs below BSRs. A first-order estimation of methane resources via petrophysical approach and Monte Carlo simulation suggests approximately 105 trillion cubic feet (TCF) of methane resources.
Elucidating the knowledge, attitude, and stigma associated with tuberculosis: a community based descriptive study in Wau and Jur River, South Sudan
Authors: Marin Peter Michael , Tryland Morten , Munyeme Musso , Jubara Ambrose Samuel , Matovu Enock , Waiswa Peter , Romano Javier Sanchez , Mutebi Francis , Onafruo David , Kitale Estella , Sabbath Esther , Buhler Kayla J. , Kankya Clovice 
Published: February 2025

Abstract

Background
Tuberculosis (TB) is a major public health problem in South Sudan. Inadequate knowledge, negative attitudes and perceived stigma may complicate the prevention efforts. This study describes knowledge, attitude, and stigma associated with TB among communities in Wau and Jur River, South Sudan.

Methods
From March to May 2023, a cross-sectional study was conducted among 352 community members randomly selected from residential blocks. A validated structured questionnaire was used to collect the required data. Descriptive, bivariate and multivariate analyses were performed.

Results
Out of 352 respondents, 51% (n = 180) were males and 49% (n = 172) were females. Majority 227 (64.5%) had poor knowledge about TB, meanwhile hearing about TB, age and level of education were associated factors. Fear of having TB was the major negative attitude (57.1%; n = 218), and most of the respondents (n = 327; 92.9%) had a perceived stigma towards TB, voicing that they disliked drinking or eating with people with TB and/or felt uncomfortable and kept their distance from people with TB.

Conclusions
Communities have little knowledge, negative attitude and perceived stigma towards people with TB. Hence, tailored health messages using local languages, training of community volunteers to reach villages without accessibility and communication network are essential to improve TB prevention and control in South Sudan.
Anterior clinoid process metastasis with sudden loss of vision: role of emergency optic nerve decompression
Authors: Rico-Pereira Marta , Muñoz-Hernández Fernando 
Published: February 2025

Abstract

Background
Anterior clinoid process metastases are rare. We present an unusual case of anterior clinoid process metastasis with sudden deterioration of visual function requiring emergency optic nerve decompression, resulting in visual recovery.

Case presentation
We report the case of a 41-year-old male patient with a diagnosis of radius leiomyosarcoma, who underwent surgery in 2014, with bone and lung metastases, who had been treated with chemotherapy and appeared to have the disease controlled at his last follow-up. 6 years later, he developed a one month history of progressive unilateral loss of visual acuity and visual field defect (initially quadrantanopia that progressed to nasal hemianopia). Brain imaging showed a contrast-enhancing lesion affecting the left anterior clinoid process with extension to the cavernous sinus and sphenoid sinus, causing compression of the left optic nerve. Although the lesion could have suggested a meningioma given the location, in the context of the patient’s oncological history, the diagnosis of metastasis was considered more likely. The patient was admitted to hospital and, during the hospital stay, developed sudden left retro-orbital pain progressing to left amaurosis over approximately 8 h. Urgent surgery was performed: a pterional craniotomy with partial tumor removal and optic nerve decompression with extradural anterior clinoidectomy. After surgery, the patient had an immediate but partial improvement in visual acuity and in the visual field defect.

Conclusions
Metastasis to the anterior clinoid process is very uncommon, with only one case previously reported in the literature. In cases of visual impairment, symptoms may deteriorate rapidly to complete loss of vision, so urgent decompressive surgery of the optic nerve may be indicated to recover visual function, although recovery may be partial.
Predicting Preeclampsia in Gestational Diabetes Mellitus Using the sFlt-1/PlGF Ratio
Authors: Noonan Sarah Brittany , Brennecke Shaun Patrick , Jones Gabriel Davis 
Published: February 2025

Abstract

Context
The soluble Fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio blood test can aid the prediction of preeclampsia (PE) in advance of a clinical diagnosis. Gestational diabetes mellitus (GDM) predisposes to PE, but may influence levels of these biomarkers independently of PE.

Objective
To determine whether the sFlt-1/PlGF ratio retains its clinical utility to predict PE in patients with GDM.

Methods
Retrospective analysis of sFlt-1/PlGF ratio and associated clinical outcome data acquired between September 2016 and September 2022, at the Royal Women's Hospital, Melbourne, Australia. 1416 sFlt-1/PlGF ratio results from pregnant women with and without GDM, and with and without PE were analysed. The main outcome measures were sFlt-1, PlGF and sFlt-1/PlGF ratio test results in relation to PE and GDM.

Results
There were no significant differences in the area under the curve (AUC), specificity, sensitivity, positive predictive value, or negative predictive value (NPV) between the PE + No GDM and PE + GDM groups in both the 0 to 7 and the 8 to 14 days before delivery categories. In the 0- to 7-day category the PE + No GDM group had an AUC of 0.82 (95% CI 0.79-0.87), sensitivity of 85.3% (95% CI 80.8-89.1%) and NPV of 92.7% (95% CI 90.5-94.5%), and the PE + GDM group had an AUC of 0.87 (95% CI 0.82-0.93), sensitivity of 89.4% (95% CI 76.9-96.5%), and NPV of 94.8% (95% CI 88.7-97.7%).

Conclusion
The results of this investigation indicate that although GDM may lead to changes in the sFlt-1/PlGF ratio, the sFlt-1/PlGF ratio test retains its clinical utility in predicting PE onset.
Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) of Extraperitoneal Abdominal Disease, is it Appropriate?
Authors: Mangieri Christopher W. , Votanopoulos Konstantinos I. , Shen Perry , Levine Edward A. 
Published: February 2025

Abstract

Introduction
Cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) candidates often have extraperitoneal abdominal disease. Current expert peritoneal surface malignancy (PSM) guidelines recommend that the presence of extraperitoneal disease is a contraindication to CRS-HIPEC.

Methods
We conducted a retrospective review of our institutional appendiceal and colorectal CRS-HIPEC registries. Two study cohorts were constructed: (1) cytoreduction with extraperitoneal abdominal disease, and (2) cytoreductions limited to peritoneal structures alone. The primary study outcome was survival. Subgroup analysis was based on the primary tumor and completeness of cytoreduction.

Results
Overall, 864 CRS-HIPEC cases were evaluated, consisting of 578 appendiceal primaries and 286 colorectal cancers. The extraperitoneal cohort included 101 patients, with 763 patients in the non-extraperitoneal group. The median follow-up time was 13.18 years. The main analysis showed no significant differences in survival times. For overall survival (OS) there was a mean OS time of 5.87 years and a median OS time of 4.43 years for extraperitoneal cytoreductions compared with a mean of 5.90 years and a median of 4.76 years for non-extraperitoneal cytoreductions (p = 0.955). Five-year OS rates did not differ at 49.1% versus 49.5% (odds ratio [OR] 1.036, 95% confidence interval [CI] 0.671–1.597, p = 0.874). Disease-free survival (DFS) times showed a mean of 4.40 years and a median of 1.93 years for extraperitoneal cases versus a mean of 5.44 years and a median of 3.05 years for non-extraperitoneal cases (p = 0.210). Five-year DFS rates also showed no differences (OR 0.894, 95% CI 0.476–1.681, p = 0.728). No significant differences in progression-free survival (PFS)Pp times (p = 0.061) were reported. Multivariate Cox regression analysis indicated that extraperitoneal CRS was not an independent predictor of OS (hazard ratio [HR] 1.281, 95% CI 0.885–1.854, p = 0.190), DFS (HR 1.087, 95% CI 0.694–1.701, p = 0.716), or PFS (HR 0.650, 95% CI 0.243–1.738).

Conclusion
We conducted the largest analysis evaluating extraperitoneal cytoreductions, with no significant differences in almost all survival outcomes. We propose that the presence of extraperitoneal abdominal disease is not a contraindication to proceeding with CRS-HIPEC.
Cytoreductive Surgery Plus HIPEC in Recurrent or Newly Diagnosed Advanced Epithelial Ovarian Cancer: a Meta-analysis
Authors: Taliento C. , Restaino S. , Arcieri M. , Scutiero G. , Greco P. , Scambia G. , Vizzielli G. 
Published: February 2025

Abstract

Background
In 2024, two randomized controlled trials (RCTs) were published, providing new high-quality evidence on HIPEC in epithelial ovarian cancer (EOC). Updating data on progression-free survival (PFS) and adverse events could offer a clearer understanding of the benefits and risks of HIPEC combined with cytoreductive surgery (CRS), with or without prior neoadjuvant chemotherapy (NACT).

Patients and Methods
An electronic search was conducted using PubMed, Web of Science, EBSCO, and CENTRAL up to 23 November 2024. We only included RCTs reporting PFS and adverse events of interval or secondary CRS, with or without HIPEC, in newly diagnosed or recurrent EOC.

Results
The meta-analysis included six RCTs. The addition of HIPEC to surgery significantly improved PFS in patients with newly diagnosed advanced-stage EOC who received NACT (HR 0.59; 95% CI 0.39–0.88; p = 0.01). No significant difference in PFS was observed between secondary CRS plus HIPEC and CRS alone in recurrent ovarian cancer without prior NACT (HR 1.22; 95% CI 0.82–1.83; p = 0.32). Regarding adverse events, a decrease in platelet count of any grade was more frequent in the HIPEC group (p = 0.03). The overall risk of acute kidney failure (AKF) was 10.6%, with a significantly higher incidence compared with CRS alone (p = 0.003).

Conclusions
The addition of HIPEC to CRS significantly improved PFS compared with surgery alone in patients with advanced EOC who received NACT. However, the treatment was associated with a higher incidence of AKF, which occurred in 10.6% of patients who underwent HIPEC.
COLLAPSE TECTOLOGY AND MODERNITY
Authors: Sukhanova Elena V. , Shilovskaya Natalia S. , Skorodumov Dmitry A. 
Published: February 2025

The modern era is characterized by a systemic exacerbation of crisis phenomena in human society. The aggravation of the global crisis and the numerous problems of modern civilization require new theoretical approaches that could help in finding adequate answers to the challenges of our time. The article searches for and concretizes science that can become a theoretical basis for the study of modern collapse scenarios. The science of catastrophes threatening civilization is called collapsology. Our article substantiates that A. Bogdanov's tectology can become a more general theoretical foundation of collapsology.
The aim of the work is to clarify the relationship between collapsology and tectology and their applicability to the study of the development of modern society.
The research methodology includes a hermeneutical method of interpreting texts; an analytical method; an interdisciplinary method; a comparative analysis that allows comparing different types of discourses of catastrophism.
The study found that the Enlightenment belief in the constant and exponential growth of society is a myth. Modernity is faced with numerous problems: an increase in the costs of human self-maintenance, an aging population and a decrease in its number as the scientific and technological development of the countries of the world grows. K. Tsiolkovsky's myth about the constant increase of joy in intelligent matter due to the progressive development of the world has been criticized - the amount of intelligent matter has increased, but the overall share of "suffering" has increased. A list of catastrophes and disorganization processes in the world has been compiled, linking tectology and collapsology. It is established that tectology, the science of universal organizational processes, can be applied to the study of conflicts and crises of our time: the optics of tectology allows us to look at civilizational crises and catastrophes as colliding organizational processes, which makes collapsology a special case of tectology.
Posterior reversible encephalopathy syndrome related to severe hypomagnesaemia
Authors: Naya Rosato Martín , Núñez Calvo María Luisa , Barrera López Lucía 
Published: February 2025

Introduction: Posterior reversible encephalopathy syndrome (PRES) might be associated with a wide spectrum of symptoms, including irreversible neurological damage. Management is primarily symptomatic and focuses on addressing the underlying causes. Case description: A 65-year-old female with a medical history of smoking, arterial hypertension and dyslipidaemia, was admitted due to dysarthria associated with ataxia, visual disturbances and diarrhoea. The neurological physical examination revealed a mild decreased strength in both legs (4/5), mild dysdiadochokinaesia and mild heel-knee dysmetria. Remarkable laboratory findings showed potassium 2.6 mmol/l and magnesium 0.24 mg/dl. Brain computed tomography (CT) showed no suggestive ischaemic areas. During hospitalisation, potassium and magnesium levels were initially corrected through intravenous supplementation. A brain magnetic resonance imaging (MRI) scan revealed symmetrical cortical alterations in the posterior regions of both cerebellar hemispheres, consistent with a diagnosis of PRES. After the exclusion of other potentially related diseases, the final diagnosis was PRES in the setting of severe hypomagnesaemia. Discussion: PRES pathophysiology is unknown, while its incidence is probably underestimated. It is suggested that rapid increases in blood pressure are thought to overwhelm the self-regulatory capability of cerebral blood flow, especially in the posterior brain regions where the regulatory flow capacity may be weaker. This might result in increased cerebral perfusion leading to oedema due to capillary leakage. PRES has been associated with poorly controlled arterial hypertension, autoimmune diseases, eclampsia and chemotherapy, among others. Conclusion: Hypomagnesaemia represents an uncommon but potentially reversible cause of PRES and should be taken into account for differential diagnosis.
Assessing the therapeutic potential of vagus nerve stimulation in autoimmune diseases: A systematic review
Authors: Chan Eubi , Mani Ali R. 
Published: February 2025

AbstractEmerging evidence suggests that the vagus nerve can modulate the immune system in experimental settings. Vagus nerve stimulation (VNS), initially developed for managing epilepsy, is now being explored as a treatment for autoimmune diseases due to its potential immunomodulatory effects. This systematic review evaluates the therapeutic potential of VNS in autoimmune diseases by critically appraising findings from human clinical studies. This systematic review was conducted in accordance with the PRISMA guideline, with a comprehensive literature search performed in Ovid, Cochrane, and PubMed databases up to July 2024. Studies focusing on VNS in patients with autoimmune diseases were eligible, and the quality of study was assessed using the QualSyst tool. Of the 53 papers identified for full‐text assessment, 19 studies met the eligibility criteria. Findings suggest that VNS is a promising adjunctive therapy for Crohn's disease and rheumatoid arthritis, showing potential to alleviate symptoms and modulate immune responses. The efficacy and safety of VNS vary widely across studies, highlighting the complex nature of autoimmune diseases and the diverse mechanisms of VNS action. Future research should prioritize large‐scale, randomized controlled trials with standardized protocols to further elucidate the efficacy, long‐term safety, and optimal parameters of VNS across various autoimmune conditions.