bluuebunny/crossref_metadata_2025_split huggingface dataset:
Off-pump minimally invasive coronary artery bypass grafting in patients with left ventricular dysfunction: the lampang experience
Authors: Ushioda Ryohei , Hirofuji Aina , Yoongtong Dit , Sakboon Boonsap , Cheewinmethasiri Jaroen , Kamiya Hiroyuki , Arayawudhikul Nuttapon 
Published: January 2024

IntroductionThe minimally invasive cardiac surgery off-pump coronary artery bypass (MICSOPCAB) is technically difficult; therefore, previous studies have indicated that MICSOPCAB should be contraindicated in patients with impaired left ventricular (LV) function. In this study, we investigated the feasibility of MICSOPCAB in patients with impaired LV function.MethodsThe 226 patients underwent MICSOPCAB between August 2017 and September 2022. Our study defined impaired LV function as ejection fraction (EF) in echocardiography 40% or less. The patients were divided into Low EF group (n = 39) and Normal EF group (n = 187).ResultsThe Low EF group was in a more critical preoperative condition than Normal EF group (41.0% in the Low EF group vs. 14.4% in the Normal EF group; p &lt; 0.001). For preoperative transthoracic echocardiography, LV end-diastolic diameter (5.5 ± 0.9 cm in the Low EF group vs. 5.0 ± 0.8 cm in the Normal EF group; p &lt; 0.001) and LV end-systolic diameter (4.4 ± 1.0 cm in the Low EF group vs. 3.4 ± 1.0 cm in the Normal EF group; p &lt; 0.001) were significantly larger in the Low EF group. No differences were found in the operative time (180 [160–240] min in the Low EF group vs. 205 [165–253] min in the Normal EF group; p = 0.231) and the median number of distal anastomoses (2 [1–2] in the Low EF group vs. 2 [1–3] in the Normal EF group; p = 0.073). Intensive care unit stay was longer in the Low EF group than in the Normal EF group (2 [1–2] in the Low EF group vs. 1 [1–2] in the Normal EF group; p = 0.010). Perioperative transfusion was more common in the Low EF group than in the Normal EF group (69.7% vs. 49.2%; p = 0.023). There were no differences in major complications, hospital stay, and 30-day mortality. The Kaplan–Meier curve showed no significant difference in postoperative major adverse cardiac or cerebrovascular events rates between the two groups (p = 0.185)ConclusionIn this study, MICSOPCAB can be performed in patients with low EF having short- and mid-term outcomes similar to patients with normal EF. Therefore, low EF should not be contraindicated in MICSOPCAB.
Forecast-Based Energy Management for Optimal Energy Dispatch in a Microgrid
Authors: Durán Francisco , Pavón Wilson , Minchala Luis Ismael 
Published: January 2024

This article describes the development of an optimal and predictive energy management system (EMS) for a microgrid with a high photovoltaic (PV) power contribution. The EMS utilizes a predictive long-short-term memory (LSTM) neural network trained on real PV power and consumption data. Optimal EMS decisions focus on managing the state of charge (SoC) of the battery energy storage system (BESS) within defined limits and determining the optimal power contributions from the microgrid components. The simulation utilizes MATLAB R2023a to solve a mixed-integer optimization problem and HOMER Pro 3.14 to simulate the microgrid. The EMS solves this optimization problem for the current sampling time (t) and the immediate sampling time (t+1), which implies a prediction of one hour in advance. An upper-layer decision algorithm determines the operating state of the BESS, that is, to charge or discharge the batteries. An economic and technical impact analysis of our approach compared to two EMSs based on a pure economic optimization approach and a peak-shaving algorithm reveals superior BESS integration, achieving 59% in demand satisfaction without compromising the life of the equipment, avoiding inexpedient power delivery, and preventing significant increases in operating costs.
Identification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Annurca Apple Flesh Polyphenol Extract
Authors: D’Errico Antonio , Nasso Rosarita , Di Maro Antimo , Landi Nicola , Chambery Angela , Russo Rosita , D’Angelo Stefania , Masullo Mariorosario , Arcone Rosaria 
Published: January 2024

Background: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are multifactorial neurodegenerative disorders that are mostly treated with drugs inhibiting key enzymes of cholinergic and aminergic neurotransmission, such as acetyl and butyryl cholinesterase (AChE, BuChE) or monoamine oxidases (MAO)-A/B, and of Aβ 1–40 aggregation. Diet plant components with multitarget functions are promising compounds in the prevention of AD and PD. Our aim was to identify neuroprotective compounds from Annurca apple polyphenol extract (AFPE). Methods: AFPE was fractionated by gel filtration, and the eluted peaks were subjected to chemical analyses (i.e., RP-HPLC and mass spectrometry), determination of inhibitory enzyme activity and cell effects by MTT, and morphology assays. Results: In AFPE, we identified thaumatin-like protein 1a, belonging to the pathogenesis-related protein (PR) family. This protein showed the best inhibitory activity on AChE, MAO-A (IC50 = 5.53 µM and 1.71 µM, respectively), and Aβ1–40 fibril aggregation (IC50 = 9.16 µM), compared to AFPE and other polyphenol-containing fractions. Among the latter, Peak 4 reverted Aβ fibril formation (IC50 = 104.87 µM). Moreover, thaumatin-like protein 1a protected AGS and MKN-28 cells from serum-deprivation-induced stress conditions. Conclusions: We showed that AFPE exerted neuroprotective functions not only through its polyphenols but also through thaumatin-like protein 1a, which acted like a multitarget molecule.
Energy-Preserving/Group-Preserving Schemes for Depicting Nonlinear Vibrations of Multi-Coupled Duffing Oscillators
Authors: Liu Chein-Shan , Kuo Chung-Lun , Chang Chih-Wen 
Published: January 2024

In the paper, we first develop a novel automatically energy-preserving scheme (AEPS) for the undamped and unforced single and multi-coupled Duffing equations by recasting them to the Lie-type systems of ordinary differential equations. The AEPS can automatically preserve the energy to be a constant value in a long-term free vibration behavior. The analytical solution of a special Duffing–van der Pol equation is compared with that computed by the novel group-preserving scheme (GPS) which has fourth-order accuracy. The main novelty is that we constructed the quadratic forms of the energy equations, the Lie-algebras and Lie-groups for the multi-coupled Duffing oscillator system. Then, we extend the GPS to the damped and forced Duffing equations. The corresponding algorithms are developed, which are effective to depict the long term nonlinear vibration behaviors of the multi-coupled Duffing oscillators with an accuracy of O(h4) for a small time stepsize h.
Los límites a la integración europea
Authors: Vernet i Llobet Jaume 
Published: January 2024

L'article du Professeur Vernet met en question le caractère inconditionnel du Droit communautaire à travers la perspective interne. L'auteur nous dit qu'il existe deux types de limites au droit dérivé européen sur le plan constitutionnel : les limites internes et celles externes, i.e., celles qui procèdent des Constitutions des Etats membres ou du Droit primaire européen. Ces deux limites peuvent être complémentaires entre elles ou coïncider.
Parmi les limites internes, l'auteur met l'accent sur certains caractères fondamentaux des Etats membres, définis par les Constitutions et qui ne peuvent pas être modifiés par le droit communautaire dans la mesure où celui-ci n'est pas chargé d'affecter ces traits essentiels qui constituent le "noyau dur" de la souveraineté des Etats. Dans le cas espagnol, qui fait l'objet de ce texte, cette limite est très claire si l'on étudie les buts constitutionnels du pouvoir constituant, du pouvoir de réforme de la Constitution et du processus d'intégration européenne.
Du point de vue de l'Union Européenne, les Traités et la jurisprudence ont élaboré toute une série de principes qui délimitent aussi en faveur des Etats les compétences des Institutions européennes, ainsi qu'on peut le déduire de l'application des principes de subsidiarité, de respect des identités nationales et des droits fondamentaux, d'attribution de compétences, de proportionnalité, de flexibilité ou coopération renforcée, et celui de l'autonomie institutionnelle.
La Ciudadanía, presupuesto de una República europea. Apuntes para una política del Derecho
Authors: López Pina Antonio 
Published: January 2024

El trabajo se plantea en qué medida el espíritu de la Constitución española ha sido incorporado a los Tratados de Maastricht y de Amsterdam y trata de pensar un proyecto europeo a la altura de los tiempos que oponer a las relaciones de poder realmente existentes. Punto de partida es la idea española del Estado social y democrático de Derecho, con su hincapié en la igual libertad. A partir de tal prejuicio (Vorverstãndnis), trata de pergeñar una situación europea alternativa bajo el Derecho Comunitario vigente.
Tras una breve descripción del estadio actual de la Comunidad Europea, analiza la tabla de derechos de los ciudadanos, que no viene sino a reflejar el arquetipo del Estado social-liberal del siglo XIX. Las contradicciones que afloran en el ordenamiento jurídico vigente y nuevos constreñimientos desatan una dinámica propia, que impulsa el proceso de cambio. Sobre tal telón de fondo, la ciudadanía europea -que al ser compartida por ciudadanos de distinta nacionalidad, deja tras de sí los límites territorial-soberanos del Estado -se ofrece como quicio a una política del Derecho que supere contradicciones fundamentales y lleve nuestras sociedades a identificarse plenamente con la Unión Europea.
Integración europea y Constitución europea
Authors: Pérez Calvo Alberto 
Published: January 2024

La construction communautaire européenne s'est effectuée jusqu'à présent à petits pas et par la technique juridique du Traité international. On est arrivé ainsi à un haut degré d'intégration, même si le système montre une complexité excessive et en conséquence une absence de clarté, ce qui diminue sa légitimité et son efficacité.
Après une première étape où le seul moteur des Communautés Européennes étaient les Etats membres, l'irruption d'un Parlement européen élu au suffrage universel a mis en scène un nouvel acteur doté d'une légitimité et d'une autonomie propres. Le nouveau Parlement a cherché la simplification du système et, surtout, une place appropriée dans le processus de décision jusqu'alors monopolisé par le Conseil. C'est ainsi que surgissent les projets Spinelli (1984) et celui de la Constitution européenne (1994).
Pour leur part, les Traités de Maastricht et d'Amsterdam, même s'ils ont compliqué encore davantage le système, ont amélioré d'une façon remarquable la situation du Parlement européen dans le processus de décision communautaire.
Aujourd'hui, en Europe communautaire apparaissent deux éléments matériels qui pourraient favoriser la perspective d'une Constitution européenne : d'une part, l'Union européenne qui, en plus d'un acquis institutionnel considérable, offre des institutions très significatives dans ce sens, comme la citoyenneté européenne ; d'autre part, l'Etat, qui a acquis une nouvelle dimension, communautaire, indispensable pour pouvoir franchir ce pas.
Cependant, l'auteur, qui défend le caractère nécessaire de la construction européenne face au caractère contingent d'une Constitution européenne, se montre sceptique à l'égard de cette possibilité. D'abord, parce que les objectifs substantiels poursuivis par les promoteurs d'une Constitution européenne, peuvent être atteints par les moyens conventionnels internationaux, comme jusqu'à présent. Ensuite, et fondamentalement, en raison de la grande difficulté qu'entraînerait la cession de la souveraineté à la nouvelle entité européenne de la part des Etats membres, i.e., de ses gouvernants mais aussi de ses citoyens.
Les mutations de la notion de Constitution et le droit constitutionnel
Authors: Pierré-Caps Stéphane 
Published: January 2024

Entendido clásicamente como el derecho del poder político y del ciudadano, el derecho constitucional parece confundirse en adelante con la "Constitución normativa", teorizada por KELSEN y sostenida por la imposición del constitucionalismo norteamericano y la generalización del control de inconstitucionalidad de las leyes. Aboliendo las fronteras entre los ordenes jurídicos nacionales, pero también entre estos últimos y el orden jurídico internacional, el derecho constitucional normativo anunciaría el advenimiento de la ciudadanía del mundo, incluso su propio fin histórico.
Ocultando así el propio dualismo del concepto de Constitución, no solamente construcción racional, sino también resultado de la historia, de la acción y del combate del hombre, la imposición de la "Constitución normativa" choca contra la realidad de los hechos y se muestra incapaz de solventar la cuestión de la identidad colectiva de la sociedad política : ¿ quiénes somos y cómo vivir juntos ?
Esta es hoy la cuestión constitucional, es decir la de la "Constitución demòtica". Reconociendo el arraigo nacional de la democracia constitucional y la impotencia del constitucionalismo liberal clásico frente a las separaciones nacionales, a reserva de organizarei "Estado sin sustancia" en Bosnia, Kosovo, incluso en la Unión europea, el derecho constitucional demòtico es a la vez un método de análisis que restituye el dualismo inherente al fenómeno constitucional, apareciendo la Constitución no como el principio de la vida jurídica sino como su punto de llegada ; y también un objeto de análisis, dedicándose a la juridicización del querer vivir juntos.
La juridictionnalisation du droit international ou la révolution en trompe-l'œil.
Authors: Weckel Philippe 
Published: January 2024

While the growth in international legal disputes is spectacular, one should consider the nature of the phenomenon. Logically it reflects the needs of the States comprising the international society ; due process of law provides them with legal security and the guarantee of an impartial and definitive application of the law. The qualitative contribution it makes thus illustrates the link between the creation of jurisdictions applying international law and the concept of good governance.
This transformation of law also reflects the decentralised nature of the international legal system. It creates competition between various controlling bodies with a clear risk of potential contradiction in case law. However, it also creates a highly stimulating situation and is a powerful factor in promoting an evolution in the law and in its application.
The establishment of jurisdictions applying international law profoundly changes its very nature. It enhances the judicial function in that this becomes associated with the increasing rule of law in major political disputes and with fundamental questions that increasingly concern society on an international level. One cannot call it a revolution as neither has the international power structure been modified, in spite of the emergence of a world civil society, nor has the essential nature of international law been changed. However it confirms that a country under the Rule of Law is legalist in its approach to foreign policy.
Analisa Faktor-Faktor yang Berpengaruh terhadap Stunting : Literatur Review
Authors: Santoso Puguh 
Published: January 2024

Stunting pada anak merupakan masalah nasional yang disebabkan oleh multifaktor yang berdampak negatif terhadap sumber daya manusia di masa yang akan datang antara lain berdampak terhadap penurunan kecerdasan, kerentanan terhadap penyakit, menghambat pertumbuhan ekonomi dan produktifitas kerja dan memperburuk kesenjangan serta dimana terjadi pertumbuhan tinggi badan lebih pendek dari usia pada umumnya. Stunting pada anak balita merupakan konsekuensi dari beberapa faktor yang sering dikaitkan dengan kemiskinan termasuk gizi, kesehatan, sanitasi dan lingkungan. Ada lima faktor utama penyebab stunting yaitu kemiskinan, sosial dan budaya, peningkatan paparan terhadap penyakit infeksi, kerawanan pangan dan akses masyarakat terhadap pelayanan kesehatan. Tujuan dari literature review ini adalah untuk menganalisa faktor faktor yang berpengaruh terhadap stunting Metode: Literature yang didapatkan dari SINTA, PUBMED, Garuda dan google scholar databased. 10 literatu re review menggunakan beberapa desain yaitu deskriptif eksploratif, cross sectional, deskriptif cross sectional study, case-control, deskriptif analitik, deskriptif dari tahun 2013-2023 kemudian dilakukan analisa PICO Hasil: hasil penelitian menunjukan faktor faktor yang bervariasi . Kesimpulan: Faktor faktor stunting bisa dipengaruhi oleh kemiskinan, sosial dan budaya, peningkatan paparan terhadap penyakit infeksi, kerawanan pangan dan akses masyarakat terhadap pelayanan kesehatan secara sendiri atau bersama sama.
Kata Kunci: faktor penyebab, stunting,balita
Pharmacokinetics of Local Anesthetics in Dentistry: The Example of Articaine-Containing and Mepivacaine- Containing Anesthetics
Authors: Machin A. , Fokina S. A. , Mityushkina T. A. , Filippov K. Yu. , Korovushkina E. K. 
Published: January 2024

Aim. To analyze current data on the pharmacokinetics of drugs used for local anesthesia in dental practice, with particular emphasis on articaine-containing and mepivacaine-containing anesthetics. Materials and Methods. The study of up-to-date information from the Cyberleninka, Elibrary, Google Scholar and PubMed electronic databases was carried out during a systematic review of the literature. Selected and included articles, the content of which concerns the pharmacokinetics of local anesthetics articaine and mepivacaine. Results. 55 publications were reviewed. After analyzing the literature for inclusion criteria, the total number of publications has become 42. Conclusions. According to the analyzed data, the choice of local anaesthetic solution should be made individually for each patient and be based on the pharmacokinetics of the drug.
Analisis Perbandingan 2 Dan 3 Blade Turbin Angin Kecil Sumbu Vertikal Tipe Savonius
Authors: Sugeng Ucok Mulyo , Hadi Veriah , Setiadi Bambang 
Published: January 2024

Abstrak
Tujuan dari penelitian ini adalah penelitian, dan melakukan uji coba dari sebuah turbin angin tipe savonius dalam kapasitas kecil. Pemukiman wilayah pesisir pantai memiliki wilayah yang potensial untuk dikembangkan energi angin baik yang skala kecil maupun skala menengah. Penelitian ini bertujuan untuk mengetahui perfomansi turbin angin sumbu vertical tipe savonius hasil rancang bangun, dengan diameter kincir keseluruhan 50 cm dan tinggi 100 cm. Untuk meneliti efisiensi turbin angin sumbu vertical tipe savonius jumlah blade 2 dan 3. Pada kesempatan ini akan dilakukan Analisa perfoma turbin Angin hasil rancang bangun pada jumlah blade 2 dan 3. Hasil rancang bangun turbin angin jumlah blade 2 menghasilkan effisiensi terbesar 299 % pada kecepatan angin 1 m/s dan pada jumlah blade 3 menghasilkan efisiensi terbesar 306,8% pada kecepatan angin 1m/s.
Kata kunci: Turbin angin, efisiensi, kecepatan angin.
The impact of the duration of wave treatment on the development of yeast populations
Authors: Grishin Artem G. , Karpenko Dmitry V. , Karagod Viktorija A. 
Published: January 2024

Introduction: The scientific literature does not contain research on the influence of monochromatic light treatment on the development of bottom-fermenting beer yeast populations.Purpose: An analysis of the literature data allowed us to suppose the possibility of activating the development of the beer yeast Saccharomyces cerevisiae population through preliminary treatment with light of visible spectrum wavelengths, providing technological and economic efficiency of such an impact method on a production scale.Materials and Methods: The object of research was the process of cultivating a population of bottom-fermenting beer yeast Saflager S-189 (Fermentis). The subject was the influence of preliminary treatment of the seed yeast with monochromatic light with a wavelength of 980 nm on this process. Its effectiveness was assessed by the weight loss of the cultivation medium, the increase in the total cell titre, the proportion of unviable and "fed" cells. A KFK-2 photoelectrocolorimeter was used as a source of monochromatic light with wavelengths of the visible range. Seeding of mediums and sample preparation for analysis were performed in a BAVnp-01-"Laminar-S."-1.2 antibacterial air medium box. The yeast's fermenting activity was assessed by the weight loss of the nutrient medium; the total cell titre was established by counting in a Goryaev's chamber; the percentage of unviable cells was determined using methylene blue dye; the percentage of "fed" yeast cells was established by staining glycogen with iodine solution.Results: Preliminary treatment of the seed yeast with monochromatic light (980 nm) allowed increasing the fermenting activity of bottom-fermenting beer yeast by 10-15% compared to the control, which is consistent with the results of other research groups concerning populations of microorganisms of other genera and species. The values of other determined indicators - the proportion of "fed" and unviable cells, the total yeast cell titre - in the experimental variants were at the level of those in the control samples or slightly inferior to them. Data on the influence of the duration of seed yeast irradiation for 60, 120 or 180 minutes on the listed controlled indicators are presented, and the authors express the opinion about the appropriateness of its conduction for 60 minutes.Conclusion: The principle possibility of activating the development of a population of bottom-fermenting beer yeast by preliminary treatment of seed yeast with light with a wavelength of 980 nm, which can give an economic effect on an industrial scale, is substantiated; the necessity of testing the technological method under study in conditions close to production ones, i.e., for brewing wort with an irradiated suspension of seed yeast, is noted.