bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of pharmacokinetics of single-dose primaquine in undernourished versus normally nourished children diagnosed with Plasmodium vivax malaria in Mumbai
Authors: Gogtay NJ , Karande S , Kadam PP , Momin S , Thatte UM 
Published: January 2024

Background:
The pharmacokinetics of primaquine [PQ] have been the subject of studies in both adults and healthy participants. However, there is no study on its pharmacokinetics in a setting of undernourishment. In India, there is evidence to show considerable malnourishment in children that in turn can affect drug pharmacokinetics. Given that the country is moving towards malaria elimination, the present study was planned with the objective of comparing pharmacokinetics of the drug in undernourished children relative to normally nourished children.

Materials and Methods:
After Institutional Ethics Committee approval, children of either gender between the ages of 5 and 12 years and smear-positive for Plasmodium vivax malaria were included. Nourishment status was determined using the Indian Academy of Pediatrics classification of protein energy malnutrition based on Khadilkar's growth charts. Twelve children each were enrolled in the two groups. PQ was given in the dose of 0.3 mg/kg/d and blood collections were made at 0, 1, 2, 3, 4, 6, 8 and 24 hours post-dosing. Levels were estimated by high-performance liquid chromatography. Chloroquine in the dose of 25 mg/kg was given over three days along with supportive care.

Results:
Of the 24 children, there were 17 boys and 7 girls. There was a statistically significant difference in the body weight between the undernourished and the normally nourished children [21.5 ± 5.52 vs. 28.8 ± 8.84, P < 0.05]. PQ levels showed wide inter-individual variation in both groups. No significant difference was seen in any pharmacokinetic parameter between the two groups.

Discussion:
This study adds to the limited body of evidence on the pharmacokinetics of PQ in children with malaria and indicates that the dosing of primaquine could potentially be independent of the nourishment status.
Willingness to quit tobacco and its correlates among Indian tobacco users—Findings from the Global Adult Tobacco Survey India, 2016–17
Authors: Kar SS , Sivanantham P , Rehman T , Chinnakali P , Thiagarajan S 
Published: January 2024

Background:
Willingness to quit in a tobacco user forms the basis for future quit attempts and quitting successfully.

Objective:
To determine the prevalence and correlates of willingness to quit among tobacco users in India using the Global Adult Tobacco Survey (GATS), India, 2016–2017.

Methods:
GATS, 2016–17 was a multistage geographically clustered sample survey done among 74,037 individuals aged 15 years and above across all the states and two of the Union Territories of India. Data of all those reported using any form of tobacco were studied for past attempts to quit tobacco, advised to quit by a health care provider, and exposure to anti-tobacco messages delivered through various media and the correlation of these with the willingness to quit using multivariate analysis.

Results:
Of the 21,085 current tobacco users in the survey, 11,679 (52.2%), were willing to quit all forms of tobacco. Multivariate analysis showed that those in younger age groups (OR: 1.39 [1.23–1.56]), higher education levels (OR 1.15 [1.05–1.18]), time of first tobacco use in the day being more than 60 min after waking up in the morning (OR 1.11 [1.03–1.2]), history of attempts to quit in the past 12 months (OR 1.78 [1.69–1.87]), those advised to quit by health care provider in the past 12 months (OR 1.11 [1.06–1.17]), those using single form of tobacco (OR 1.1 [1.05–1.17]), those exposed to anti-tobacco messages in newspapers/magazines (OR 1.1 [1.05–1.17]), and cinemas (1.14 [1.08–1.20]) were more willing to quit compared to their counterparts.

Conclusion:
Enhanced publicizing of anti-tobacco messages through the currently employed media, and ensuring that doctors give a brief advice to quit during any contact with a tobacco user could improve the willingness to quit and the consequent quit rate, especially among those tobacco users who are in younger age groups and who have attempted to quit earlier.
Comparison of primary arthrodesis versus open reduction with internal fixation for Lisfranc injuries
Authors: Han PF , Zhang ZL , Chen CL , Han YC , Wei XC , Li PC 
Published: January 2024

Objective:
Multiple studies have compared primary arthrodesis versus open reduction with internal fixation (ORIF) for surgical treatment of fractures of the Lisfranc joint, but their results have been inconsistent. Therefore, the present systematic review and meta-analysis was performed to compare the clinical efficacy of arthrodesis versus ORIF for the treatment of Lisfranc injuries.

Methods:
Through searching the Embase, PubMed, PMC, CINAHL, PQDT, and Cochrane Library databases (from July 1998 to July 2018), we identified five case-controlled trials and two randomized controlled trials that compared the clinical efficacy of primary arthrodesis and ORIF for treating Lisfranc injuries. The extracted data were analyzed using Review manager 5.3 software.

Results:
Through comparisons of data for primary arthrodesis and ORIF groups, we found no significant differences in the anatomic reduction rate, revision surgery rate, and total rate of complications between the different treatment approaches. However, arthrodesis was associated with a significantly better American Orthopedic Foot and Ankle Society (AOFAS) score, return to duty rate, and visual analog scale score with a lower incidence of hardware removal compared with ORIF.

Conclusions:
For the treatment for Lisfranc injuries, primary arthrodesis was superior to ORIF based on a higher AOFAS score, better return to duty rate, lower postoperative pain, and lower requirement for internal fixation removal. Further evidence from future randomized controlled trials with higher quality and larger sample sizes is needed to confirm these findings.
Predictors of response to pulmonary rehabilitation in stable chronic obstructive pulmonary disease patients
Authors: Ragaselvi S , Janmeja AK , Aggarwal D , Sidana A , Sood P 
Published: January 2024

Context:
Pulmonary rehabilitation (PR) has become a standard of care in the management of chronic obstructive pulmonary disease (COPD). However, a significant proportion of the patients do not show benefit after the PR program.

Aims:
The study was planned to find different patient- and/or disease-related factors that may predict response to PR in stable COPD.

Subjects and Methods:
A total of 102 stable COPD patients were prospectively enrolled. Baseline evaluation and investigations, including spirometry, arterial blood gas analysis, and bone mineral density assessment, were done. Thereafter, all patients underwent an 8-week comprehensive outpatient PR program that consisted of exercise training, education, nutritional, and psychological counseling. The response to PR was dichotomously (yes/no) defined by the combined improvement in exercise tolerance (6-min walk distance [6MWD] +54 m) and quality of life (St. George's Respiratory Questionnaire [SGRQ] score - 4 points) measured before and after the program. Thereafter, different predefined factors were analyzed for their possible association with the PR response.

Results:
A total of 80 patients (78.4%) completed the PR program and were subjected for analysis. Out of them, 42 (52.5%) showed improvement in both 6MWD and SGRQ score (46 in 6MWD and 54 in SGRQ score). After application of multivariate logistic regression analysis, forced expiratory volume in 1 s <50% predicted (odds ratio [OR]: 2.9; 95% confidence interval [CI]: 1.1–8.3; P = 0.04) and osteoporosis (OR: 0.26; 95% CI: 0.13–0.53; P < 0.001) were found as independent factors predicting PR efficacy.

Conclusions:
Poor baseline lung function predicts a short-term improvement in exercise capacity and quality of life in COPD patients, whereas osteoporosis is a negative predictor of PR response. Active search for these factors may help in better patient selection, thus leading to improved outcome after PR.
Efficacy of an Herbal Preparation (Atomy’s HemoHIM®) against Ventilator-associated Pneumonia: A Randomized Controlled Clinical Trial
Authors: Khamooshpour Ghazal , Mahjubipour Hossein , Farsaei Shadi 
Published: January 2024

Objective:
Despite the standard guideline recommendations to prevent ventilator-associated pneumonia (VAP), it has remained one of the common lung infections in the intensive care unit (ICU). This clinical trial was designed to evaluate the effect of HemoHIM®, a mixture of traditional Korean medicinal plants, on preventing VAP in ICU patients.

Methods:
This randomized controlled clinical trial was conducted on mechanically ventilated adult ICU patients with a clinical pulmonary infection score of VAP ≤6 in the first 48 h of ventilation. Patients in the intervention group received a packet of HemoHIM daily and orally for 7 days in addition to standard prevention strategies. However, in the control group, only standard prevention strategies were carried out. All patients were followed daily for VAP incidence for 14 days.

Findings:
The overall VAP incidence was 36.4 and 57.4 episodes per 1000 days of mechanical ventilation in the intervention and control groups, respectively (P = 0.041; odds ratio = 0.26; 95% confidence interval = 0.070–0.944). The median length of mechanical ventilation during study follow-up was significantly lower in the intervention than in the control group (P = 0.033). The number of pneumonia-free days during the study was considerably higher in the intervention group (P value of the log-rank test = 0.023).

Conclusion:
According to the results of this study, the HemoHIM herbal supplement had beneficial effects in preventing the occurrence of VAP and significantly reduced the incidence of pneumonia in the intervention group. Further comprehensive research is required to draw more accurate conclusions.
Comparative efficacy and safety between endoscopic submucosal dissection, surgery and definitive chemoradiotherapy in patients with cT1N0M0 esophageal cancer
Authors: Luo Shu-Ai , Sun Yu-Ying , Zeng Ya-Ting , Huang Chun-Yu 
Published: January 2024

BACKGROUND
Endoscopic submucosal dissection (ESD) and surgical resection are the standard of care for cT1N0M0 esophageal cancer (EC), whereas definitive chemoradiotherapy (d-CRT) is a treatment option. Nevertheless, the comparative efficiency and safety of ESD, surgery and d-CRT for cT1N0M0 EC remain unclear.
AIM
To compare the efficiency and safety of ESD, surgery and d-CRT for cT1N0M0 EC.
METHODS
We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th, 2022. We analyzed demographic, medical recorded, histopathologic characteristics, imaging and endoscopic, and follow-up data. The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments. Inverse probability of treatment weighting (IPTW) was used to minimize potential confounding factors.
RESULTS
We retrospectively analyzed patients who underwent ESD (n = 99) or surgery (n = 220) or d-CRT (n = 16) at the Sun Yat-sen University Cancer Center from 2017 to 2019. The median follow-up time for the ESD group, the surgery group, and the d-CRT group was 42.0 mo (95%CI: 35.0-60.2), 45.0 mo (95%CI: 34.0-61.75) and 32.5 mo (95%CI: 28.3-40.0), respectively. After adjusting for background factors using IPTW, the highest 3-year overall survival (OS) rate and 3-year recurrence-free survival (RFS) rate were observed in the ESD group (3-year OS: 99.7% and 94.7% and 79.1%; and 3-year RFS: 98.3%, 87.4% and 79.1%, in the ESD, surgical, and d-CRT groups, respectively). There was no difference of severe complications occurring between the three groups (P ≥ 0.05). Multivariate analysis showed that treatment method, histology and depth of infiltration were independently associated with OS and RFS.
CONCLUSION
For cT1N0M0 EC, ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery, with a similar rate of severe complications occurring.
Coca-Cola consumption vs fragmentation in the management of patients with phytobezoars: A prospective randomized controlled trial
Authors: Liu Fu-Guo , Meng De-Feng , Shen Xia , Meng Dan , Liu Ying , Zhang Ling-Yun 
Published: January 2024

BACKGROUND
Gastric phytobezoars (GPBs) are very common in northern China. Combined therapy involving carbonated beverage consumption and endoscopic lithotripsy has been shown to be effective and safe. Existing studies on this subject are often case reports highlighting the successful dissolution of phytobezoars through Coca-Cola consumption. Consequently, large-scale prospective investigations in this domain remain scarce. Therefore, we conducted a randomized controlled trial to examine the effects of Coca-Cola consumption on GPBs.
AIM
To evaluate the impact of Coca-Cola on GPBs, including the dissolution rate, medical expenses, ulcer rate, and operation time.
METHODS
A total of 160 consecutive patients diagnosed with GPBs were allocated into two groups (a control group and an intervention group) through computer-generated randomization. Patients in the intervention group received a Coca-Cola-based regimen (Coca-Cola 2000-4000 mL per day for 7 d), while those in the control group underwent emergency fragmentation.
RESULTS
Complete dissolution of GPBs was achieved in 100% of the patients in the intervention group. The disparity in expenses between the control group and intervention group (t = 25.791, P = 0.000) was statistically significant, and the difference in gastric ulcer occurrence between the control group and intervention group (χ 2 = 6.181, P = 0.013) was also statistically significant.
CONCLUSION
Timely ingestion of Coca-Cola yields significant benefits, including a complete dissolution rate of 100%, a low incidence of gastric ulcers, no need for fragmentation and reduced expenses.
Identification of Mayaro Virus Genotype D in Rondônia, Brazil
Authors: Pimentel Edilene Pereira , Queiroz Jackson Alves da Silva , Ribeiro Jessiane Rodrigues , Moreira Hillquias Monteiro , Passos-Silva Ana Maísa , Oliveira Adrhyan Araújo da Silva , Roque Rosemary Aparecida , Vieira Deusilene 
Published: January 2024

ABSTRACT.
The Mayaro virus (MAYV) is a significant reemerging arbovirus of public health concern, responsible for outbreaks in several countries including Brazil. In this study, 857 samples of patients with acute fever in the state of Rondônia, Brazil, were analyzed by reverse transcriptase qualitative polymerase chain reaction (RT-qPCR) to detect Zika, dengue, and chikungunya viruses. The mean age of the population was 38 years (SD = 17.46). Negative samples were subjected to duplex RT-qPCR to detect MAYV and Oropouche virus. One MAYV-positive sample with a negative result for all other viruses tested was identified and subsequently sequenced using the automated Sanger method and, through phylogenetic analysis, was characterized as belonging to genotype D, making it the first case of Mayaro in humans isolated in Rondônia. The symptoms reported by the positive patient were fever, vomiting, back pain, nausea, severe arthralgia, and retro-orbital pain. The study reinforces the need for differential diagnosis for Mayaro in the laboratory routine and the importance of genomic surveillance of this virus, mainly due to the similarity of symptoms with other arboviruses, which makes this screening difficult.
Ürolojik Cerrahi Uygulanan Hastaların Taburculuk Eğitimi Memnuniyeti ve Etkileyen Faktörler
Authors: DIĞIN Figen , KIZILCIK ÖZKAN Zeynep , ALTINAZ Meltem 
Published: January 2024

Amaç: Taburculuk eğitimi hastanın ameliyat sonrası günlük yaşam aktivitelerine hazırlanması ve yaşam kalitesinin geliştirilmesi açısından önemlidir. Bu araştırmanın amacı ürolojik cerrahi uygulanan hastaların taburculuk eğitimi memnuniyetini ve etkileyen faktörleri belirlemektir.
Yöntem: Tanımlayıcı ve kesitsel tipteki araştırma bir üniversite hastanesinin üroloji kliniğinde cerrahi işlem geçiren 136 hastanın katılımıyla 1 Ocak-31 Ağustos 2022 tarihleri arasında gerçekleştirildi. Veri toplamada Hasta tanıtım formu ve Taburculuk Eğitimi Memnuniyet Ölçeği kullanıldı. Veri analizinde Mann Whitney U testi, Kruskal Wallis testi, Spearman Korelasyon analizi ve Bonferroni düzeltmeli Mann Whitney U testi kullanıldı.
Bulgular: Hastaların yaş ortalamasının 57.7±15.0 (18-81) yıl olduğu, %74.3’ ünün erkek olduğu belirlendi. Hastaların Taburculuk Eğitimi Memnuniyet Ölçeği puan ortalamaları 90.0±15.0 olarak bulundu. En yüksek alt boyut puan ortalaması taburculuk süreci (13.7±1.8 önem düzeyi:4.57) ve en düşük alt boyut puan ortalaması evde bakım (28.6±6.6 önem düzeyi:4.08) olarak bulundu. Hastaların Taburculuk Eğitimi Memnuniyet Ölçeği puan ortalamalarının yaşa (p=0.016) ve ameliyat sonrası yatış süresine (p=0.029) göre istatistiksel olarak anlamlı farklılık gösterdiği belirlendi.
Sonuç: Hastaların taburculuktan memnuniyet düzeyleri yüksek düzeyde bulundu. Yaş ve ameliyat sonrası hastanede yatış süresindeki artışın hastaların taburculuktan memnuniyetlerini olumsuz etkilediği belirlendi.
The Degree of Effectiveness of Managing of Extracurricular Activities in Reducing the Phenomenon of Violence in Northern Schools within the Green Line
Authors: Tarabeih Hatem Awad , Salameh Kayed Muhammad 
Published: January 2024

The study aimed to discover the degree of effectiveness of managing of extracurricular activities in reducing the violence in northern schools within the Green Line, and the difference in it according to the variables of sex, job title and school level. A descriptive methodology was applied using a questionnaire was consisted of (32) items, and its validity and reliability were verified. The sample consisted of (694) educational supervisors, principals, and teachers. The results indicated that the degree of effectiveness management of extracurricular activities in reducing the violence with northern schools within the Green Line were moderate; And the results appeared in the effectiveness of managing extracurricular activities in reducing the phenomenon of violence in northern schools as a whole from the study subjects’ point of view as a result of changing the job title in favor of teachers, while there were no statistically significant differences on the variables of sex and school level.
The Level of the Role of School Management in Achieving Job Satisfaction for Special Education Teachers in Middle Schools and its Relationship with their Level Performance
Authors: Khalaily Awham Ali , Ashour Khalifa Moustafa , Karasneh Sameeh Mahmoud 
Published: January 2024

The study aimed to determine the level of the role of school management in achieving job satisfaction for special education teachers in middle schools in the Green Line and its relationship with their level of performance. A descriptive correlational methodology was used, through the level of role of school management by achieving job satisfaction questionnaire, which consisted of (39) items, and the performance with Teachers questionnaire, which included (53) items. Their validity and reliability indications were confirmed. The sample consisted of (405) principals and teachers. Results indicated that the level of the role of school management by achieving job satisfaction for special education teachers in middle school and the degree of the level of performance among teachers were moderate; A statistically significant positive correlation between the level of the role of school management in achieving job satisfaction for special education teachers in middle school and the level of performance among teachers.
The Practicing Degree of Middle Schools’ Principals in The North District within The Green Line for Servant Leadership and its Relation to Organizational Excellence level
Authors: Abu Raya Hiam Ali , Ashour Mohammad Ali , Al-Omari Khaled Mohammad 
Published: January 2024

The study aimed to identify the relationship between the degree of practicing servant leadership among middle school principals in the north district within The Green Line and the level of organizational excellence in those schools. The descriptive correlational methodology and the questionnaire were used, the sample consisted of (67) principals, and (320) teachers, who were chosen using the stratified random sample method according to the job title. The results showed a high degree of servant leadership practice among principals, and of organizational excellence, and a positive correlation between practicing servant leadership and the level of organizational excellence. The study recommended delegating principals much power to make decentralized decisions, and enforcement of the local community's role in school goals and policies.
Pesantren dan Konstruksi Realitas Sosial
Authors: Sholeh Moh. 
Published: January 2024

Judul Buku : Membangun dari Keterpencilan: Soft Contructivism, Kesadaran Aktor dan Modernitas Dunia PesantrenPenulis : Aniek NurhayatiPenerbit : Daulatpress Tahun : 2016 Buku ini, awalnya merupakan tugas akhir Aniek Nurhayati pada Program Doktor Ilmu Pertanian di Universitas Brawijaya Malang. Secara umum buku ini berupaya memahami peran pesantren dalam melakukan perubahan sosial di pedesaan.
Kontribusi Kekuatan Otot Lengan Dan Kelenturan Pinggang Terhadap Keterampilan Senam Lantai Handspring Pada Mahasiswa Pendidikan Jasmani Universitas Bengkulu
Authors: Oddie Barnanda Rizky  , Syafrial  , Septian Raibowo  , Andika Prabowo  , Andes Permadi  
Published: January 2024

Penelitian ini bertujuan untuk mengukur kontribusi kekuatan otot lengan dan kelenturan pinggang terhadap senam lantai handspring pada Mahasiswa Pendidikan Jasmani Universitas Bengkulu. Penelitian ini dilakukan di Program Studi Pendidikan Jasmani Universitas Bengkulu. Metode penelitian yang digunakan adalah statistik dengan korelasi product moment dan korelasi ganda. Sampel pada penelitin ini adalah Mahasiswa Pendidikan Jasmani Universitas Bengkulu sebanyak 25 Mahasiswa yang diambil dengan teknik random sampling. Hasilnya nilai r data = 0,63 > r tabel = 0,396 dan Ha diterima. Artinya terdapat hubungan yang signifikan antara X1 dan Y. nilai r = 0,84 > r tabel = 0,396 dan hasil Ha diterima. Artinya terdapat hubungan yang signifikan antara X1, X2, dan Y. Disimpulkan terdapat kontribusi yang signifikan sebesar 72,25% antara kekuatan otot lengan dan fleksibilitas pinggul terhadap keterampilan handspring.