bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of minimally invasive tubular approaches for management of the lumbar spinal synovial cysts: a meta-analysis
Authors: Chen Ying , Yu Pei , Xu Hui , Li Shenggang , Wang Qing , Wu Chunwang , Wang Ji , Ji Fufu , Huang Qiang , Lan Qing 
Published: November 2023

AbstractThe treatment of lumbar spinal synovial cysts (LSCs) which are relatively rare but can cause neurogenic dysfunction and intractable pain has been a controversial topic for many years. Surgical excision of LSCs is the standard treatment for patients in whom conservative treatment options fail. This meta-analysis was undertaken to compare clinical outcomes between minimally invasive approaches using tubular retractors (microscopic vs. endoscopic) and traditional percutaneous approaches for LSCs. Studies reporting surgical management of LSCs were searched in the Cochrane Library, PubMed and Web of Science database. This meta-analysis was reported following the PRISMA Statement, registered in Prospero (CRD42021288992). A total of 1833 patients were included from both the related relevant studies (41 studies, n = 1831) and the present series (n = 2). Meta-analysis of minimally invasive tubular approaches revealed no statistically significant difference in pain improvement, dural tear, residual cyst, recurrence and operation time between minimal groups with traditional groups (p > 0.05). Minimal groups had better Functional improvement of 100% (95% CI 1.00–1.00; p < 0.001, I2 = 75.3%) and less reoperation rates of 0% (95% CI − 0.00–0.00; p = 0.007, I2 = 47.1%). Postoperative length of hospital stay and intraoperative bleeding in minimal groups were also less than traditional groups (p < 0.05). Subgroup analysis revealed endoscopic groups had less operation time (p = 0.004), and there was no significant difference in the rest. For patients with LSCs but without obvious clinical and imaging evidence of vertebral instability, even when preoperative stable grade 1 spondylolisthesis is present, minimally invasive tubular approaches without fusion may provide the best outcome in surgical management.
Experimental Study on Structural Performance of Cast-in-Place Frame Printed Concrete Wall
Authors: Fu Yanan , Zhang Ying , Wu Lei 
Published: November 2023

AbstractA growing number of nations and regions have printed concrete structures thanks to the application of 3D printing technology in the field of civil engineering. However, the houses built with printed concrete are mostly printed concrete wall structures with composite load-bearing walls and cast-in-place frames. This structure solely takes into account the performance of the structure under vertical loads, which does not address its ability to withstand horizontal loads. In this paper, wall specimens were designed and tested under horizontal reciprocal loads in order to investigate the structural performance of this cast-in-place border-frame printed concrete wall structure under horizontal loads. Four factors are examined in order to determine how well the cast-in-place frame printed concrete wall structure performs when subjected to horizontal loads: column longitudinal reinforcement strain, hysteresis curve, skeleton curve, and energy dissipation capacity. According to the test results, the addition of the wall increased the bearing capacity and accumulated energy dissipation of the specimen, but the increase in stiffness also caused the structural ductility to decrease. As a result, cracks were more likely to generate at the wall–column joints, so the stiffness matching between the printed concrete wall and the cast-in-place side frame needed to be further coordinated to obtain a higher ductility. It turns out that the wall sections have little impact on the seismic performance of the members.
Tillandsia landbeckii phyllosphere and laimosphere as refugia for bacterial life in a hyperarid desert environment
Authors: Hakobyan Anna , Velte Stefanie , Sickel Wiebke , Quandt Dietmar , Stoll Alexandra , Knief Claudia 
Published: November 2023

Abstract
Background
The lack of water is a major constraint for microbial life in hyperarid deserts. Consequently, the abundance and diversity of microorganisms in common habitats such as soil are strongly reduced, and colonization occurs primarily by specifically adapted microorganisms that thrive in particular refugia to escape the harsh conditions that prevail in these deserts. We suggest that plants provide another refugium for microbial life in hyperarid deserts. We studied the bacterial colonization of Tillandsia landbeckii (Bromeliaceae) plants, which occur in the hyperarid regions of the Atacama Desert in Chile, one of the driest and oldest deserts on Earth.

Results
We detected clear differences between the bacterial communities being plant associated to those of the bare soil surface (PERMANOVA, R2 = 0.187, p = 0.001), indicating that Tillandsia plants host a specific bacterial community, not only dust-deposited cells. Moreover, the bacterial communities in the phyllosphere were distinct from those in the laimosphere, i.e., on buried shoots (R2 = 0.108, p = 0.001), indicating further habitat differentiation within plant individuals. The bacterial taxa detected in the phyllosphere are partly well-known phyllosphere colonizers, but in addition, some rather unusual taxa (subgroup2 Acidobacteriae, Acidiphilum) and insect endosymbionts (Wolbachia, “Candidatus Uzinura”) were found. The laimosphere hosted phyllosphere-associated as well as soil-derived taxa. The phyllosphere bacterial communities showed biogeographic patterns across the desert (R2 = 0.331, p = 0.001). These patterns were different and even more pronounced in the laimosphere (R2 = 0.467, p = 0.001), indicating that different factors determine community assembly in the two plant compartments. Furthermore, the phyllosphere microbiota underwent temporal changes (R2 = 0.064, p = 0.001).

Conclusions
Our data demonstrate that T. landbeckii plants host specific bacterial communities in the phyllosphere as well as in the laimosphere. Therewith, these plants provide compartment-specific refugia for microbial life in hyperarid desert environments. The bacterial communities show biogeographic patterns and temporal variation, as known from other plant microbiomes, demonstrating environmental responsiveness and suggesting that bacteria inhabit these plants as viable microorganisms.
VBCG: 20 validated bacterial core genes for phylogenomic analysis with high fidelity and resolution
Authors: Tian Renmao , Imanian Behzad 
Published: November 2023

Abstract
Background
Phylogenomic analysis has become an inseparable part of studies of bacterial diversity and evolution, and many different bacterial core genes have been collated and used for phylogenomic tree reconstruction. However, these genes have been selected based on their presence and single-copy ratio in all bacterial genomes, leaving out the gene's 'phylogenetic fidelity' unexamined.

Results
From 30,522 complete genomes covering 11,262 species, we examined 148 bacterial core genes that have been previously used for phylogenomic analysis. In addition to the gene presence and single-copy rations, we evaluated the gene's phylogenetic fidelity by comparing each gene's phylogeny with its corresponding 16S rRNA gene tree. Out of the 148 bacterial genes, 20 validated bacterial core genes (VBCG) were selected as the core gene set with the highest bacterial phylogenetic fidelity. Compared to the larger gene set, the 20-gene core set resulted in more species having all genes present and fewer species with missing data, thereby enhancing the accuracy of phylogenomic analysis. Using Escherichia coli strains as examples of prominent bacterial foodborne pathogens, we demonstrated that the 20 VBCG produced phylogenies with higher fidelity and resolution at species and strain levels while 16S rRNA gene tree alone could not.

Conclusion
The 20 validated core gene set improves the fidelity and speed of phylogenomic analysis. Among other uses, this tool improves our ability to explore the evolution, typing and tracking of bacterial strains, such as human pathogens. We have developed a Python pipeline and a desktop graphic app (available on GitHub) for users to perform phylogenomic analysis with high fidelity and resolution.
Study on permeability evolution and damage mechanism along the EGS fracture in heat mining stage under thermal stress/cracking
Authors: Zhang Wei , Wang Dong , Wang Zenglin , Guo Tiankui , Wang Chunguang , He Jiayuan , Zhang Le , Zheng Peng , Qu Zhanqing 
Published: November 2023

AbstractAs main heat exchange channel in enhanced geothermal system, the evolution of hydraulic conductivity in fracture is significance for efficient heat mining. For the thermal stress or thermal cracking spontaneously induced by the temperature difference between low-temperature fluid and hot rock in heat mining stage, it is necessary to explore the damage mechanism along EGS fracture and the corresponding permeability evolution. Firstly, the long-term permeability tests under high temperature (50–200 ℃) were conducted by the self-developed high temperature seepage experimental device. Then, a coupled THM-D model was constructed to describe the damage distribution along fracture. Combined with experimental and simulation results, relationship between the thermal stress/cracking and the evolution of fracture permeability is revealed. The results indicate that during high-temperature (200 ℃) experiments, the fracture permeability first increases rapidly under the low-temperature induced thermal stress/cracking, then decreases due to the blockage effect induced by the debris particles generated in thermal cracking along fracture. The enhancement of injection velocity and heterogeneity are all conducive to the emergence of thermal cracking in matrix along fracture. Simultaneously, high confining pressure has a negative effect on the migration of debris particles of thermal cracking, which contribute to prevent the blockage of debris particles.
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Authors: Takahashi Nozomi , Kondo Yutaka , Kubo Kenji , Egi Moritoki , Kano Ken-ichi , Ohshima Yoshiyasu , Nakada Taka-aki 
Published: November 2023

Abstract
Background
The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/pharmacodynamics and specific drug properties for critically ill patients is unclear. Here, we conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the effectiveness of TDM-based regimen in these patients.

Methods
Articles from three databases were systematically retrieved to identify relevant randomized control studies. Version two of the Cochrane tool for assessing risk of bias in randomized trials was used to assess the risk of bias in studies included in the analysis, and quality assessment of evidence was graded using the Grading of Recommendations Assessment, Development, and Evaluation approach. Primary outcome was the 28-day mortality and secondary outcome were in-hospital mortality, clinical cure, length of stay in the intensive care unit (ICU) and target attainment at day 1 and 3.

Results
In total, 5 studies involving 1011 patients were included for meta-analysis of the primary outcome, of which no significant difference was observed between TDM-based regimen and control groups (risk ratio [RR] 0.94, 95% confidence interval [CI]: 0.77–1.14; I2 = 0%). In-hospital mortality (RR 0.96, 95% CI: 0.76–1.20), clinical cure (RR 1.23, 95% CI: 0.91–1.67), length of stay in the ICU (mean difference 0, 95% CI: − 2.18–2.19), and target attainment at day 1 (RR 1.14, 95% CI: 0.88–1.48) and day 3 (RR 1.35, 95% CI: 0.90–2.03) were not significantly different between the two groups, and all evidence for the secondary outcomes had a low or very low level of certainty because the included studies had serious risk of bias, variation of definition for outcomes, and small sample sizes.

Conclusion
TDM-based regimens had no significant efficacy for clinical or pharmacological outcomes. Further studies with other achievable targets and well-defined outcomes are required.
Trial registration: Clinical trial registration; PROSPERO (https://www.crd.york.ac.uk/prospero/), registry number: CRD 42022371959. Registered 24 November 2022.
The All-on-four concept for fixed full-arch rehabilitation of the edentulous maxilla and mandible: a longitudinal study in Japanese patients with 3–17-year follow-up and analysis of risk factors for survival rate
Authors: Uesugi Takashi , Shimoo Yoshiaki , Munakata Motohiro , Sato Daisuke , Yamaguchi Kikue , Fujimaki Michiya , Nakayama Kazuhisa , Watanabe Tae , Malo Paulo 
Published: November 2023

Abstract
Purpose
Implant-supported immediately loaded fixed full-arch rehabilitation via All-on-four treatment yields good long-term results for both the maxilla and the mandible. However, the risk factors affecting long-term implant survival are unknown, and the long-term prognosis of All-on-four concept procedures in Japanese individuals has not been elucidated. We aimed to determine the cumulative implant survival rate after 3–17-year follow-up and identify the associated risk factors.

Methods
We analysed 561 cases (307 maxillae, 254 mandibles) with 2364 implants (1324 maxillae, 1040 mandibles) that received All-on-four treatment. We investigated the cumulative implant- and patient-level survival rates and various risk factors for implant failure. Statistical analysis was performed using the log-rank test for differences in Kaplan–Meier curves, univariate analysis using the Chi-square test, and multivariate analysis for risk factors affecting the survival rate.

Results
The cumulative survival rate was 94.4% by patient level and 97.4% by implant level for the maxilla, and 96.7% by patient level and 98.9% by implant for the mandible, with up to 17 years of follow-up. The maxillary survival rate at the implant level was significantly lower (p < 0.05). Furthermore, the maxillary survival rate within 24 months was significantly lower at the implant level (p < 0.01). Multivariate analysis revealed that the maxilla was the most significant risk factor (p < 0.01).

Conclusions
All-on-four treatment yielded high long-term survival rates in Japanese patients. However, the maxilla showed a significantly lower cumulative survival rate than the mandible, while early failure was significantly higher. Furthermore, the maxilla was a significant risk factor influencing the survival rate.
A health-social service partnership programme for improving the health self-management of community-dwelling older adults: a hybrid effectiveness-implementation pilot study protocol
Authors: Wong Arkers Kwan Ching , Wong Frances Kam Yuet , Chow Karen Kit Sum , Kwan Dilys Kwai Sin , Lau Dubby Yun Sang , Lau Avis Cheuk Ki 
Published: November 2023

Abstract
Background
The ageing population requires seamless, integrated health and social care services in the community to promote the health of older adults. However, inadequate financial resources, a lack of clear operational guidelines, and various organisational work cultures may affect the implementation quality and sustainability of these services. As a unique approach, this study seeks to examine the preliminary effects of a health-social partnership programme on the health self-management of community-dwelling older adults in Hong Kong. Additionally, the study seeks to ascertain key insights into the mechanisms and processes required to implement and sustain a self-care management programme in broader practice in community settings.

Methods
This study will use a hybrid effectiveness-implementation design. During the 3-month programme, subjects in the intervention group will receive four Zoom video conference sessions and four telephone calls conducted by a health-social service team that will include a nurse case manager, community workers, general practitioners, a Chinese medicine practitioner, and social workers. Subjects in the control group will receive a monthly social telephone call from a trained research assistant to rule out the possible social effect of the intervention. The reach, effectiveness, adoption, implementation, and maintenance framework (i.e. RE-AIM framework) will be used to evaluate the implementation and effectiveness outcomes. Of the five dimensions included in the RE-AIM framework, only effectiveness and maintenance outcomes will be collected from both the intervention and control groups. The outcomes of the other three dimensions—reach, adoption, and implementation—will only be collected from subjects in the intervention group. Data will be collected pre-intervention, immediately post-intervention, and 3 months after the intervention is completed to evaluate the maintenance effect of the programme.

Discussion
This programme will aim to enhance health-promoting self-care management behaviours in older adults dwelling in the community. This will be the first study in Hong Kong to use the hybrid effectiveness-implementation design and involve key stakeholders in the evaluation and implementation of a health self-management programme using a health-social service partnership approach. The programme, which will be rooted in the community, may be used as a model, if proven successful, for similar types of services.

Trial registration
Clinicaltrials.gov, NCT04442867. Submitted 19 June 2020
Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe
Authors: Xiao Runsha , Zheng Fan , Kang Kuo , Xiao Lei , Bi Anyao , Chen Yiting , Zhou Qi , Feng Xueping , Chen Zhikang , Yin Hao , Wang Wei , Chen Zihua , Cheng Xiaomiao , Zeng Wenbin 
Published: November 2023

Abstract

Background
Colorectal cancer (CRC) is a prominent global cancer with high mortality rates among human beings. Efficient diagnosis and treatment have always been a challenge for CRC management. Fluorescence guided cancer therapy, which combines diagnosis with therapy into one platform, has brought a new chance for achieving precise cancer theranostics. Among this, photosensitizers, applied in photodynamic therapy (PDT), given the integration of real-time imaging capacity and efficacious treatment feasibility, show great potential to serve as remarkable tools. Although much effort has been put into constructing photosensitizers for locating and destroying CRC cells, it is still in high need to develop novel photosensitizers to attain specific detection and fulfil effective therapy.

Methods

Probe HTI was rational synthesized for the diagnosis and treatment of CRC. Spectrometric determination was carried out first, followed by the
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generation ability test. Then, HTI was displayed in distinguishing CRC cells from normal cells Further, the PDT effect of the photosensitizer was studied in vitro. Additionally, HTI was used in CRC BALB/c nude mice model to validate its viscosity labelling and tumor suppression characteristics.

Results

We successfully fabricated a mitochondrial targeting probe, HTI, together with remarkable viscosity sensitivity, ultralow background interference, and excellent
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generation capacity. HTI was favorably applied to the viscosity detection, displaying a 11-fold fluorescent intensity enhancement in solvents from 1.57 cp to 2043 cp. Then, it was demonstrated that HTI could distinguish CRC cells from normal cells upon the difference in mitochondrial viscosity. Moreover, HTI was qualified for producing
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with high efficiency in cells, supported by the sparkling signals of DCFH after incubation with HTI under light irradiation. More importantly, the viscosity labelling and tumor suppression performance in CRC CDX model was determined, enriching the multifunctional validation of HTI in vivo.

Conclusions

In this study, HTI was demonstrated to show a sensitive response to mitochondrial viscosity and possess a high
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generation capacity. Both in vitro cell imaging and in vivo tumor treatment trials proved that HTI was effectively served as a robust scaffold for tumor labeling and CRC cells clearance. This breakthrough discovery held immense potential for advancing the early diagnosis and management of CRC through PDT. By leveraging HTI's properties, medical professionals could benefit from improved diagnostic accuracy and targeted treatment in CRC management, ultimately leading to enhanced patient outcomes.
Association between serum uric acid/high-density lipoprotein cholesterol ratio and hypertension among reproductive-aged women
Authors: Han Xiaoxue , Tan Xuan , Liu Mengyuan , Wei Yiling , He Andong , Pan Ying , Qiu Di , Li Ruiman 
Published: November 2023

Abstract
Background
Uric acid/high-density lipoprotein cholesterol ratio (UHR) is a novel index of inflammation and metabolism that has been investigated in various diseases. However, association between UHR and hypertension among reproductive-aged women is unclear.

Methods
In this cross-sectional study, we investigated the association between serum UHR and hypertension among 5485 women aged 20–44 years based on the National Health and Nutrition Examination Survey (NHANES) database using various methods, including univariate and multivariate logistic regression analysis, stratified analysis, and spline regression. P < 0.05 was considered statistically significant.

Results
There was significant difference in UHR between the women with and without hypertension (P < 0.001). After adjusting for several covariates, UHR was positively correlated with hypertension (OR > 1, P < 0.001). In the subgroup analysis, the positive correlations still remained between UHR and hypertension in women with various age and those with BMI ≥ 30 kg/m2 (P < 0.05) excepted for adjusting for all covariates. We further found an inflection point of the threshold effect for UHR, and the prevalence of hypertension showed different increased trends below and above the threshold.

Conclusion
This study indicated a positive association between serum UHR and hypertension among reproductive-aged women, indicating that UHR is a potential clinical marker of hypertension in women.