bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein and ferritin in predicting the functional outcome in stroke patients
Authors: Sanober Arshi , Khan Siraj Ahmed , Afshan Jabeen Shaik , Dominic Sachin , Ahrar Shakeeb , Das Priyanka , Luqman Hajra , Kompella Saibaba S. S. , Sreedevi N. N. , Bhaskar M Vijaya , Mohammed Noorjahan 
Published: December 2023

Abstract

Background:
Biomarkers that predict the outcome of stroke are critical for treatment, considering them to be a valuable adjunct to routine clinical examination and imaging data.

Methods:
Thirty-one patients admitted with stroke along with 30 controls were included in the study. Patients were divided into ischaemic and haemorrhagic stroke groups based on radiological findings. The study group was evaluated within 48 h of symptom onset for clinical stroke severity (Scandinavian Stroke Scale [SSS] and National Institute of Health Stroke Scale). Functional status before the stroke (modified Rankin Scale [mRS]) and at discharge was evaluated. The association of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP) and serum ferritin concentrations with stroke severity and functional outcomes at discharge in acute ischaemic and haemorrhagic stroke patients.

Results:
The median NT-proBNP, hsCRP and ferritin serum concentrations were significantly high for cases when compared to controls (P < 0.05). However, serum concentrations of NT-proBNP, hsCRP and ferritin were not significantly different when ischaemic and haemorrhagic stroke patients were compared. HsCRP showed a negative correlation with SSS score on admission and showed a positive correlation with mRS at discharge. In multivariate adjusted regression models, hsCRP remained associated with worse functional outcomes at discharge.

Conclusions:
In acute stroke patients, elevated concentration of hsCRP is associated with greater clinical stroke severity and worse functional outcomes at discharge. Hence, it can be used along with computed tomography scan/magnetic resonance imaging for assessment of stroke severity.
Rare haematological complication of a rheumatological disease
Authors: Kumar Dhanavath Naik Arun , Naini Abhilash , Rajkumar Medigadda , Rohit Lagisetti , Rao Modugu Nageswara , Uppin Megha 
Published: December 2023

Abstract
A 16-year-old female presented with complaints of low-grade fever for 4 months associated with generalised weakness, loss of appetite, significant loss of weight and loss of hair. On examination, pallor was evident. Rest of the examination was normal. Initial investigations revealed haemoglobin of 7 g/dL, white blood cell count of 3000 cells/mm3 and platelet count of 25,000/mm3. Bone marrow biopsy revealed 30% cellularity, suggestive of hypoplastic marrow. Further investigations revealed anti-nuclear antibody (4+ homogeneous pattern and 2+ cytoplasmic pattern); anti-dsDNA antibody was positive, low complements. A diagnosis of hypoplastic anaemia secondary to systemic lupus erythematosus was made.
Management of Discoloured Maxillary Central Incisor with Intracoronal Bleaching
Authors: Haridas Harsha , George Sibin , Muliyar Sabir 
Published: December 2023

Abstract
Dentistry has an array of treatment options to harmonise a smile with discoloured teeth. Bleaching is an extremely promising option. Bleaching is a safe and conservative approach to tackle discolorations, hence gaining wider acceptance. Intracoronal bleaching of non-vital teeth involves the use of oxidising agents within the coronal portion of an endodontically treated tooth to remove tooth discolouration. The objectives of treatment are to reduce or eliminate discolouration, improve the degree of coronal translucency and alleviate present and prevent future adverse clinical signs or symptoms. The successful outcome depends mainly on the cause, correct diagnosis, case selection and proper application of bleaching technique.
Bioprinting: The Future of Maxillofacial Prosthetic Rehabilitation
Authors: Pranav A. G. , Madhavan Ranjith , Sheejith M. , Francis Nivea T. 
Published: December 2023

Abstract
Bioprinting is an additive printing process in which the bio-ink containing the extracellular matrix-like material with stem cells and active biomolecules is deposited in a precise location with the help of a computer-aided design (CAD) system. Three-dimensional (3D) bioprinting is a developing technology that is derived from the evolution of 3D printing. The ability to print biological tissues like traditional 3D plastic and metal printing has resulted in the birth of a new era of 3D printing and tissue engineering. It was originally defined as ‘organ printing’, and this process involves a CAD model, which aids in converting and designing the maxillofacial prostheses, and then, it is fabricated through printing by deposition of cells, biomaterials and biomolecules. Murphy and Atala described 3D bioprinting as ‘layer-by-layer precise positioning of biological materials, biochemicals and living cells, with spatial control of the location of functional components to fabricate 3D structures’. 3D bioprinting covers a broad range of bioprinting techniques that can be used to print tissue and organ models to help research drugs and potential treatments. The future is created in the present; bioprinting and its applications will change the outlook of dentistry. This article has illustrated the concepts, materials used, techniques, limitations and prospects of bioprinting, which helps in the fabrication of maxillofacial prostheses.
Children’s Experiences Using Various Appliances for Class II Malocclusion: A Cross-sectional Study
Authors: Suresh Kavya , Peedikayil Faizal C. , Kottayi Soni , Aravind Athira 
Published: December 2023

Abstract

Background:
Skeletal Class II correction is one of the most challenging malocclusions for a dental surgeon. The appliances used in their treatment have advantages and disadvantages regarding patient comfort. Therefore, the aim of this study was to evaluate the experiences of patients regarding the use of various removable appliances for Class II malocclusion.

Methodology:
Patients were divided into three groups regarding the type of orthopaedic appliance used, i.e. headgear, twin block and a combination of twin block with headgear. The subjects were given a questionnaire which consisted of 15 multiple-choice questions. The children answered the questions in a one-to-one session with the principal investigator in the presence of their parents. The data were collected and descriptive statistics were done, and P < 0.05 was considered statistically significant.

Results:
Out of 75 patients, 49 were undergoing treatment with headgear, 14 with twin block and 12 with a combination of twin block and headgear. Amongst these patients, toothache was observed in all patient groups. Pain in temporomandibular joint (TMJ) was found to be statistically significant (P = 0.0397) in subjects using twin block and twin block with headgear. Patients had difficulties during sleeping and speech also.

Conclusion:
This study has shown that pain of the teeth, jaw pain and sleep difficulties were the common problems encountered while using the appliances. The study also showed that patients had problems with pronunciation. TMJ pain was significant in patients using twin block and twin block with headgear.
Success Rates of Immediately Loaded Implants in the Maxilla – A 10-year Follow-up Study
Authors: Vidyadharan Arun Kumar , Cho Sang-Choon , Jinendra Anju , Rajeev Gayathri 
Published: December 2023

Abstract

Introduction:
To restore missing teeth in the mouth, dental implants are crucial. Total edentulism leaves the patient unable to chew, smile or communicate well, which can cause a psychological collapse in day-to-day activities. The objectives of this retrospective study were to report the 10-year success rates of patients with immediately loaded implants in the fully edentulous maxilla by measuring the bone level at the coronal/crestal aspect annually and also to determine the survival rates and complications of the full-arch prosthesis.

Materials and Methods:
Seventy-seven implants (Ankylos, Dentsply, Tulsa, OK, USA) were inserted and immediately loaded in 10 fully edentulous maxillae. Patients were rehabilitated with a cement-retained metal-reinforced provisional bridge of 10–12 units, and all implants were loaded on the same day of placement. At the 12-month follow-up and each year thereafter, the prostheses were removed, and a clinical evaluation of the peri-implant tissues and implant mobility was made for each implant. The age of the patients included in the study ranged between 45 and 77 years, with the average age being 61 years old. Radiographic bone levels were recorded post-loading at years 1–10 annually.

Results:
In the group of immediate loading with simultaneous augmentation, 19 of 47 implants had received vertical or horizontal augmentation due to insufficient ridge height or width. In the other group, none of the 30 immediately loaded implants received augmentation either before or simultaneous with implant placement. After a clinical and radiographic follow-up period of 12–130 months, none of these implants were lost, and the probing depths around the implants were within normal limits. None of the prostheses reported prostheses loosening, abutment screw loosening or abutment screw fracture. In one case, maxillary fixed full-arch cement-retained final prostheses had to be replaced due to a fracture of the prostheses framework, and in two cases had to be replaced due to extensive ceramic chipping; hence, the cumulative survival rate of the prostheses was 70% at the end of 10 years.

Conclusion:
These results seem to demonstrate that a maxillary fixed full-arch prosthesis that is supported by at least six to eight implants in uniform distribution, even with simultaneous grafting, allows good long-term success for immediately loaded implants.
Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial
Authors: Wu Cong-Zi , Shi Zhen-Yu , Wu Zhen , Lin Wen-Jun , Chen Wei-Bo , Jia Xue-Wen , Xiang Si-Cheng , Xu Hui-Hui , Ge Qin-Wen , Zou Kai-Ao , Wang Xu , Chen Jia-Li , Wang Ping-Er , Yuan Wen-Hua , Jin Hong-Ting , Tong Pei-Jian 
Published: December 2023

BACKGROUND
Osteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before the final option of knee replacement, arthroscopic surgery was the most widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to the forefront of treatment to prevent the progression of OA. Currently, MFAT has been successfully applied to treat different types of orthopedic diseases.
AIM
To assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA (KOA).
METHODS
A randomized, multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang, China. Overall, 302 patients diagnosed with KOA (Kellgren-Lawrence grades 2-3) were randomized to the MFAT group (n = 151, were administered MFAT following arthroscopic surgery), or the control group (n = 151, were administered hyaluronic acid following arthroscopic surgery). The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, the visual analog scale (VAS) score, the Lequesne index score, the Whole-Organ Magnetic Resonance Imaging Score (WORMS), and safety over a 24-mo period from baseline.
RESULTS
The changes in the WOMAC score (including the three subscale scores), VAS pain score, and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups, as well as when comparing values at the posttreatment visit and those at baseline (P < 0.001). The MFAT group consistently demonstrated significant decreases in the WOMAC pain scores and VAS scores at all follow-ups compared to the control group (P < 0.05). Furthermore, the WOMAC stiffness score, WOMAC function score, and Lequesne index score differed significantly between the groups at 12 and 24 mo (P < 0.05). However, no signiﬁcant between-group differences were observed in the WORMS at 24 mo (P = 0.367). No serious adverse events occurred in both groups.
CONCLUSION
The MFAT injection combined with arthroscopic surgery treatment group showed better mid-term clinical outcomes compared to the control group, suggesting its efficacy as a therapeutic approach for patients with KOA.
Peri-operative score for elderly patients with resectable hepatocellular carcinoma
Authors: Conticchio Maria , Inchingolo Riccardo , Delvecchio Antonella , Ratti Francesca , Gelli Maximiliano , Anelli Massimiliano Ferdinando , Laurent Alexis , Vitali Giulio Cesare , Magistri Paolo , Assirati Giacomo , Felli Emanuele , Wakabayashi Taiga , Pessaux Patrick , Piardi Tullio , di Benedetto Fabrizio , de'Angelis Nicola , Briceño Javier , Rampoldi Antonio , Adam Renè , Cherqui Daniel , Aldrighetti Luca Antonio , Memeo Riccardo 
Published: December 2023

BACKGROUND
Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma (HCC), also in elderly population. Despite this, the evaluation of patient condition, liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and mortality.
AIM
To identify new perioperative risk factors that could be associated with higher 90- and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk score.
METHODS
A multicentric, retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC; several independent variables correlated with death from all causes at 90 and 180 d were studied. The coefficients of Cox regression proportional-hazards model for six-month mortality were rounded to the nearest integer to assign risk factors' weights and derive the scoring algorithm.
RESULTS
Multivariate analysis found variables (American Society of Anesthesiology score, high rate of comorbidities, Mayo end stage liver disease score and size of biggest lesion) that had independent correlations with increased 90- and 180-d mortality. A clinical risk score was developed with survival profiles.
CONCLUSION
This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality.
Drug induced autoimmune hepatitis: An unfortunate case of herbal toxicity from Skullcap supplement: A case report
Authors: Thakral Nimish , Konjeti Venkata Rajesh , Salama Fady William 
Published: December 2023

BACKGROUND
The surge in traditional herbal dietary supplement (HDS) popularity has led to increased drug-induced liver injuries (DILI). Despite lacking evidence of efficacy and being prohibited from making medical claims, their acceptance has risen over sevenfold in the last two decades, with roughly 25% of United States (US) adults using these supplements monthly. An estimated 23000 emergency room visits annually in the US are linked to HDS side effects. NIH-funded research suggests HDS contribute to 7-20% of DILI cases, with similar trends in Europe—Spain reporting 2% and Iceland up to 16%. Patients with acute liver failure from HDS undergo liver transplantation more frequently than those from prescription medicines. Here we describe a case of drug-induced autoimmune hepatitis due to Skullcap supplements, this association appears to be the first documented instance in literature.
CASE SUMMARY
A middle-aged Caucasian woman, previously healthy, presented with sudden jaundice. Four months earlier, her liver enzymes were normal. She mentioned recent use of Skullcap mushroom supplements. Tests for chronic liver disease were negative. The first liver biopsy indicated severe resolving drug-induced liver injury. Despite treatment, she was readmitted due to worsening jaundice. Follow-up tests raised concerns about autoimmune hepatitis. A subsequent biopsy confirmed this diagnosis. The patient responded as expected to stopping the medication with improvement in liver enzymes.
CONCLUSION
This scenario highlights an uncommon instance of DILI caused by Skullcap supplements. It's crucial for hepatologists to recognize this connection due to the increasing prevalence of herbal supplements.
Factors associated with gastrointestinal stromal tumor rupture and pathological risk: A single-center retrospective study
Authors: Liu Jia-Zheng , Jia Zhong-Wen , Sun Ling-Ling 
Published: December 2023

BACKGROUND
Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal mesenchymal tumor with potential malignancy. Once the tumor ruptures, regardless of tumor size and mitotic number, it can be identified into a high-risk group. It is of great significance for the diagnosis, treatment, and prognosis of GIST if non-invasive examination can be performed before surgery to accurately assess the risk of tumor.
AIM
To identify the factors associated with GIST rupture and pathological risk.
METHODS
A cohort of 50 patients with GISTs, as confirmed by postoperative pathology, was selected from our hospital. Clinicopathological and computed tomography data of the patients were collected. Logistic regression analysis was used to evaluate factors associated with GIST rupture and pathological risk grade.
RESULTS
Pathological risk grade, tumor diameter, tumor morphology, internal necrosis, gas-liquid interface, and Ki-67 index exhibited significant associations with GIST rupture (P < 0.05). Gender, tumor diameter, tumor rupture, and Ki-67 index were found to be correlated with pathological risk grade of GIST (P < 0.05). Multifactorial logistic regression analysis revealed that male gender and tumor diameter ≥ 10 cm were independent predictors of a high pathological risk grade of GIST [odds ratio (OR) = 11.12, 95% confidence interval (95%CI): 1.81-68.52, P = 0.01; OR = 22.96, 95%CI: 2.19-240.93, P = 0.01]. Tumor diameter ≥ 10 cm, irregular shape, internal necrosis, gas-liquid interface, and Ki-67 index ≥ 10 were identified as independent predictors of a high risk of GIST rupture (OR = 9.67, 95%CI: 2.15-43.56, P = 0.01; OR = 35.44, 95%CI: 4.01-313.38, P < 0.01; OR = 18.75, 95%CI: 3.40-103.34, P < 0.01; OR = 27.00, 95%CI: 3.10-235.02, P < 0.01; OR = 4.43, 95%CI: 1.10-17.92, P = 0.04).
CONCLUSION
Tumor diameter, tumor morphology, internal necrosis, gas-liquid, and Ki-67 index are associated with GIST rupture, while gender and tumor diameter are linked to the pathological risk of GIST. These findings contribute to our understanding of GIST and may inform non-invasive examination strategies and risk assessment for this condition.
R-I subtype single right coronary artery with congenital absence of left coronary system: A case report
Authors: Zhou Ya-Ping , Wang Lin-Li , Qiu Yuan-Gang , Huang Shu-Wei 
Published: December 2023

BACKGROUND
Isolated single coronary artery is a rare congenital anomaly. R-I subtype single coronary artery is even rarer. In this subtype, a very large right coronary artery extends in the coronary sulcus to the anterior base of the heart where it produces the left anterior descending coronary artery. Currently, only a few case reports are available in the literature for this anomaly.
CASE SUMMARY
Here, we report the case of a 62-year-old woman who presented to the cardiology clinic with decreased exercise tolerance and poor blood pressure control. The patient underwent coronary angiography (CAG) and emission computed tomography (ECT). CAG images revealed a single gigantic right coronary artery (R-I type) arising from the right coronary sinus with branches supplying the left coronary territory. The ECT results confirmed myocardial ischemia at the location of the absent left coronary artery. The ECT findings confirmed that ischemia was consistent with the vascular loss location in CAG images. In such anomalies, there is a compensatory widening of the coronary artery lumen. Medical treatment was administered, and the patient was discharged.
CONCLUSION
Isolated single coronary arteries are associated with ischemia and potentially fatal acute coronary events. Hence, controlling risk factors is critical.
Corporeal Representations of Lenin in Post‑Soviet Ideological Games
Authors: Suslov Ivan V. 
Published: December 2023

This article discusses the significance of the study of Lenin's corporeality in the context of mass and elite culture of the post-Soviet space. The author highlights the importance of understanding the role of Lenin's images in the ideological and political context and suggests analyzing them using theoretical tools. The article also shows that interest in Lenin's images persists in contemporary mass and elite culture, being realized in such strategies of representation of Lenin's bodily aspects as phantasmagoric mystification, “skomoroshchestvo”, annihilation and dehumanization.
The phantasmagoric strategy of representing the leader of the world proletariat includes attempts to depict Lenin in unusual and paradoxical bodily images, often with elements of fantasy and mystification. The strategy of “skomoroshchestvo” allows researchers and artists to play with Lenin's image and reinterpret it in a comical and absurd way. The strategy of annihilation emphasizes the contrasting views and emotions associated with Lenin's image in the contemporary world and provokes discussions about the boundaries of art, symbolism and respect for historical figures. The strategy of dehumanizing Lenin in the representation of his corporeal image is expressed in transformations that take him away from his human historical context and reduce him to an object of irony, satire and symbolic associations.
İDİL BULGAR YAZITLARINDAN MODERN ÇUVAŞ TÜRKÇESİNE İSİMLERDE ÇOKLUĞUN İŞARETLENMESİ
Authors: ARIKAN İbrahim 
Published: December 2023

Türk dilinin tarihsel Ogur kolunun modern temsilcisi olan Çuvaş Türkçesi isimlerin çokluk şeklini yapmak için kullandığı ek ile diğer Türk lehçelerinden farklılaşır. Modern metinlerine 18. yüzyıldan itibaren ulaşabildiğimiz Çuvaş Türkçesinin en eski metinleri olarak da kabul edilen İdil Bulgar Yazıtlarında Çuvaş Türkçesinde de kullanılan çokluk eki ilk kez tanıklanabilmektedir. Bu ekin Çağdaş Çuvaş Türkçesinin ilk metinlerinden başlayarak standart bir yazı dili halini aldığı 20 yüzyıl. başına kadar farklı biçimlerinin olduğu görülmektedir.
Bu makalede Çağdaş Çuvaş Türkçesinin 18.yy. metinlerinden başlayarak yapılan taramalarda tanıklanan çokluk ekinin farklı biçimleri makale içerisinde örnekleriyle anlatılmaya çalışılmıştır. Çuvaş Türkçesinin çokluk ekinin 18. yüzyıl ve 19. yüzyıl metinlerinde tanıklanan farklı biçimlerinin dilbilgiselleşme yoluyla genişleyen biçimlerle birlikte yine dilbilgiselleşme yoluyla daralan biçimler olduğu da tespit edilmiştir. Çuvaş Türkçesinin çokluk ekinin tespit edilen farklı biçimleri için gelişim seyri gösterilmeye çalışılmıştır.