bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empyema thoracic in a neonate co-infected with SARS-CoV-2 and staphylococcus arouse successfully treated with fibrinolysis: a brief report
Authors: Sabzevari Fatemeh , Sinaei Reza , Gholami Aazam , Tahmasbi Farzad 
Published: November 2023

Abstract
Background
Empyema as a rare cause of respiratory distress in neonatal period has not yet been reported after Corona virus disease 2019 (COVID-19) and even rarely in the context of bacterial infections is age group.

Case Presentation
The first neonate of quadruplets, resulting from Cesarean-Section of a 30-year-old mother without a history of previous illness, born at 34 weeks of gestation with a birth weight of 1600 gram. All four newborns were hospitalized; while the first one underwent nasal continuous positive airway pressure (N-CPAP) with a positive end-expiratory pressure of 6 and fractional inspired oxygen of 0.6, due to respiratory distress, noting a respiratory score of five out of 12.She was resuscitated one hour later due to bradycardia and underwent ventilator support. She received a single dose of pulmonary surfactant, intravenous paracetamol, and phenobarbital due to respiratory distress syndrome, Pectus Ductus Arteriosus, and unilateral clonic movements, respectively. In the lack of positive blood culture, she extubated two days later and breast-feeding was started. On day eight, she underwent high flow nasal cannula. On day 12, she suddenly developed respiratory distress, mottling, and abdominal distension, leading to N-CPAP and re-evaluation. The nasopharyngeal sampling for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) real time Polymerase chain reaction and the blood culture for staphylococcus aurous became positive. A large volume pleural effusion including septa and loculation in right hemi-thorax on chest computerized tomography scan and ultrasound was seen, necessitating to thoracotomy, which was not possible due to her general condition. Remdesivir was started and antibiotics changed to a more broad-spectrum coverage. Chest tube was inserted and Alteplase was injected for three consecutive days with beneficial effects. She had no problem for six-month follow up.

Conclusion
This was a case of empyema thoracic in the context of SARS-CoV-2 and Staphylococcus arouses co-infection. In our experience, it can be treated by chest drainage and fibrinolysis in neonatal period.
Associations between depressive symptoms and 5-year subsequent work nonparticipation due to long-term sickness absence, unemployment and early retirement in a cohort of 2,413 employees in Germany
Authors: Rose Uwe , Kersten Norbert , Pattloch Dagmar , Conway Paul Maurice , Burr Hermann 
Published: November 2023

Abstract
Background
We examined the association of depressive symptoms with subsequent events – and duration thereof – of work nonparticipation (long-term sickness absence, unemployment and early retirement).

Methods
We employed a 5-year cohort from the Study on Mental Health at Work (S-MGA), based on a random sample of employees subject to social contributions aged 31–60 years in 2012 (N = 2413). Depressive symptoms were assessed at baseline through questionnaires, while work nonparticipation was recorded in follow-up interviews. Associations of depressive symptoms with subsequent events of work nonparticipation were examined in two-part models, with events analysed by logistic regressions and their duration by generalized linear models.

Results
Medium to severe depressive symptoms were associated with events of work nonparticipation (males Odds Ratio [OR] = 3.22; 95% CI = 1.90–5.45; females OR = 1.92; 95% CI = 1.29–2.87), especially with events of long-term sickness absence in both genders and events of unemployment in males. Mild depressive symptoms were also associated with events of work nonparticipation (males OR = 1.59; 95% CI = 1.19–2.11; females OR = 1.42; 95% CI = 1.10–1.84). Among those experiencing one or more events, the duration of total work nonparticipation was twice as high among males [Exp(β) = 2.06; 95% CI = 1.53–2.78] and about one third higher [Exp(β) = 1.38; 95% CI = 1.05–1.83] among females with medium to severe depressive symptoms.

Conclusions
The present study focuses on both events and duration of work nonparticipation, which are both critical for examining societal consequences of depressive symptoms. It is key to regard also mild depressive symptoms as a possible risk factor and to include different types of work nonparticipation.
Exhaled breath particles as a novel tool to study lipid composition of epithelial lining fluid from the distal lung
Authors: Larsson Per , Holz Olaf , Koster Grielof , Postle Anthony , Olin Anna-Carin , Hohlfeld Jens M. 
Published: November 2023

Abstract
Background
Surfactant phospholipid (PL) composition plays an important role in lung diseases. We compared the PL composition of non-invasively collected exhaled breath particles (PEx) with bronchoalveolar lavage (BAL) and induced sputum (ISP) at baseline and following endotoxin (LPS) challenges.

Methods
PEx and BAL were collected from ten healthy nonsmoking participants before and after segmental LPS challenge. Four weeks later, PEx and ISP were sampled in the week before and after a whole lung LPS inhalation challenge. PL composition was analysed using mass spectrometry.

Results
The overall PL composition of BAL, ISP and PEx was similar, with PC(32:0) and PC(34:1) representing the largest fractions in all three sample types (baseline PC(32:0) geometric mean mol%: 52.1, 56.9, and 51.7, PC(34:1) mol%: 11.7, 11.9 and 11.4, respectively). Despite this similarity, PEx PL composition was more closely related to BAL than to ISP. For most lipids comparable inter-individual differences in BAL, ISP, and PEx were found. PL composition of PEx was repeatable. The most pronounced increase following segmental LPS challenge was detected for SM(d34:1) in BAL (0.24 to 0.52 mol%) and following inhalation LPS challenge in ISP (0.45 to 0.68 mol%). An increase of SM(d34:1) following segmental LPS challenge was also detectable in PEx (0.099 to 0.103 mol%). The inhalation challenge did not change PL composition of PEx.

Conclusion
Our data supports the peripheral origin of PEx. The lack of PL changes in PEx after inhalation challenge might to be due to the overall weaker response of inhaled LPS which primarily affects the larger airways. Compared with BAL, which always contains lining fluid from both peripheral lung and central airways, PEx analysis might add value as a selective and non-invasive method to investigate peripheral airway PL composition.

Trial registration
NCT03044327, first posted 07/02/2017.
Clinical and radiographic performance of preformed zirconia crowns and stainless-steel crowns in permanent first molars: 18-month results of a prospective, randomized trial
Authors: Geduk Nazli , Ozdemir Merve , Erbas Unverdi Gizem , Ballikaya Elif , Cehreli Zafer C. 
Published: November 2023

Abstract
Background
The treatment of young permanent first molars with extensive carious tissue loss may often require restoration with preformed crowns. This study compared the clinical and radiographic performance of stainless-steel crowns (SSCs) and preformed zirconia crowns (ZCs).

Methods
Forty-eight molar incisor hypomineralisation (MIH)- or caries-affected permanent molars in 20 healthy patients between 6–13-year-old were randomly divided into ZC and SSC groups (n = 24 teeth/group) in a split-mouth design. The oral hygiene levels of patients were assessed using Greene and Vermillion simplified oral hygiene index (OHI-S). Plaque accumulation and gingival health were evaluated using the Silness&Löe plaque index (PI) and Löe&Silness gingival index (GI), respectively. Clinical retention, marginal extension level, marginal adaptation of crowns and wear of the antagonist teeth were assessed at baseline, 1, 6, 12 and 18 months. The radiological assessments for evaluating the marginal adaptation of crowns and periapical pathology of crowned teeth were performed at 6 and 12 months. The data were analyzed using Kaplan–Meier analysis, Mann–Whitney U test, and two-way ANOVA.

Results
A total of forty teeth in 17 children were evaluated for 18 months. ZCs had significantly lower gingival and plaque index values than teeth restored with SSCs during all evaluation periods (p < 0.05). Neither crown type resulted in clinically-detectable wear on opposing dentition or periapical pathology. One ZC was lost at 13 months, while all SSCs survived in function clinically. The cumulative survival rates of ZCs and SSCs were 95.2% and 100% respectively.

Conclusions
Both ZCs and SSCs showed high clinical retention rates in young permanent molars. ZCs had lower plaque accumulation and better gingival health than SSCs, which were consistently associated with mild gingival inflammation.

Clinical Trial Registration Number
NCT05049694.
Automatic literature screening using the PAJO deep-learning model for clinical practice guidelines
Authors: Lin Yucong , Li Jia , Xiao Huan , Zheng Lujie , Xiao Ying , Song Hong , Fan Jingfan , Xiao Deqiang , Ai Danni , Fu Tianyu , Wang Feifei , Lv Han , Yang Jian 
Published: November 2023

Abstract
Background
Clinical practice guidelines (CPGs) are designed to assist doctors in clinical decision making. High-quality research articles are important for the development of good CPGs. Commonly used manual screening processes are time-consuming and labor-intensive. Artificial intelligence (AI)-based techniques have been widely used to analyze unstructured data, including texts and images. Currently, there are no effective/efficient AI-based systems for screening literature. Therefore, developing an effective method for automatic literature screening can provide significant advantages.

Methods
Using advanced AI techniques, we propose the Paper title, Abstract, and Journal (PAJO) model, which treats article screening as a classification problem. For training, articles appearing in the current CPGs are treated as positive samples. The others are treated as negative samples. Then, the features of the texts (e.g., titles and abstracts) and journal characteristics are fully utilized by the PAJO model using the pretrained bidirectional-encoder-representations-from-transformers (BERT) model. The resulting text and journal encoders, along with the attention mechanism, are integrated in the PAJO model to complete the task.

Results
We collected 89,940 articles from PubMed to construct a dataset related to neck pain. Extensive experiments show that the PAJO model surpasses the state-of-the-art baseline by 1.91% (F1 score) and 2.25% (area under the receiver operating characteristic curve). Its prediction performance was also evaluated with respect to subject-matter experts, proving that PAJO can successfully screen high-quality articles.

Conclusions
The PAJO model provides an effective solution for automatic literature screening. It can screen high-quality articles on neck pain and significantly improve the efficiency of CPG development. The methodology of PAJO can also be easily extended to other diseases for literature screening.
Continuing medical education in China: evidence from primary health workers’ preferences for continuing traditional Chinese medicine education
Authors: Yan Hao , Han Zhaoran , Nie Hanlin , Yang Wanjin , Nicholas Stephen , Maitland Elizabeth , Zhao Weihan , Yang Yong , Shi Xuefeng 
Published: November 2023

Abstract
Background
Continuing Medical Education (CME) is an important part of the training process for health workers worldwide. In China, training in Traditional Chinese Medicine (TCM) not only improves the expertise of medical workers, but also supports the Chinese Government’s policy of promoting TCM as an equal treatment to western medicine. CME, including learning Traditional Chinese Medicine Technologies (TCMTs), perform poorly and research into the motivation of health workers to engage in CME is urgently required. Using a discrete choice experiment, this study assessed the CME learning preferences of primary health workers, using TCMT as a case study of CME programs.

Methods
We conducted a discrete choice experiment among health workers in Shandong Province, Guizhou Province, and Henan provinces from July 1, 2021 to October 1, 2022 on the TCMT learning preferences of primary health workers. The mixed logit model and latent class analysis model were used to analyze primary health workers’ TCMT learning preferences.

Results
A total of 1,063 respondents participated in this study, of which 1,001 (94.2%) passed the consistency test and formed the final sample. Our key finding was that there were three distinct classes of TCMT learners. Overall, the relative importance of the seven attributes impacting the learning of TCMTs were: learning expenses, expected TCMT efficacy, TCMT learning difficulty, TCMT mode of learning, TCMT type, time required to learn, and expected frequency of TCMT use. However, these attributes differed significantly across the three distinct classes of TCMT learners. Infrequent users (class 1) were concerned with learning expenses and learning difficulty; workaholics (class 2) focused on the mode of learning; and pragmatists (class 3) paid more attention to the expected TCMT efficacy and the expected frequency of TCMT use. We recommend targeted strategies to motivate TCMT learning suited to the requirements of each class of TCMT learners.

Conclusion
Rather than a single TCMT medical education program for primary health workers, CME programs should be targeted at different classes of TCMT learners.
COVID-19-related global health governance and population health priorities for health equity in G20 countries: a scoping review
Authors: Mac-Seing Muriel , Gidey Meron , Di Ruggiero Erica 
Published: November 2023

AbstractSince the declaration of the COVID-19 pandemic, the promotion of health equity including the health of various population sub-groups has been compromised, human rights jeopardised, and social inequities further exacerbated. Citizens worldwide, including in the Group of 20 (G20) countries, were affected by both global health governance (GHG) processes and decisions and public health measures taken by governments to respond to COVID-19. While it is critical to swiftly respond to COVID-19, little is known about how and to what extent the GHG is affecting population health priorities for health equity in global economies such as the G20 countries. This scoping review synthesised and identified knowledge gaps on how the COVID-19-related GHG is affecting population health priorities for policy, programme, and research in G20 countries. We followed the five-stage scoping review methodology promoted by Arksey and O’Malley and the PRISMA Extension for Scoping Reviews guidelines. We searched four bibliographic databases for references conducted in G20 countries and regions and published in English and French, between January 2020 and April 2023. Out of 4,625 references and after two phases of screening, 14 studies met the inclusion criteria. G20 countries included in the review were Australia, Brazil, Canada, China, France, India, Italy, Japan, Russia, South Africa, the United Kingdom, the United States of America, and the European Union. We found insufficient collaboration and coordination and misalignment among governance actors at multiple levels. In most cases, equity considerations were not prioritised while unequal consequences of COVID-19 public health measures on population groups were widely reported. COVID-19-related population health priorities mainly focused on upstream and midstream determinants of health. Our scoping review showed the stark inequities of COVID-19 public health outcomes, coupled with a prevalent lack of coherent collaboration and coordination among governance actors. Moreover, governance as an object of empirical study is still emerging when examining its intersection with global health and population health policy, programme, and research. An urgent shift is required to effectively act upon structural health determinants that include transformative and comprehensive policies for prevention, equity, resilience, and sustainable health.
Rewilding: a requirement for a sustainable future
Authors: Arya Ashish Kumar 
Published: November 2023

AbstractNowadays rewilding has received an increasing focus as a sustainable conservation tool for restoring damaged or disturbed habitats. Many types of rewilding initiatives have been implemented all over the globe with the goal of reinstalling the extinct or lost fauna as well as restoring ecological relationships and natural processes. The effectiveness of rewilding initiatives depends on a comprehensive understanding of the ecological functions, habitat needs, social behaviour, and interrelation among various animal species. This Collection invites contributions that portray different aspects and the importance of rewilding.
Bacteriophages: an overview of the control strategies against phytopathogens
Authors: Nawaz Aneela , Zafar Sabeena , Shahzadi Muqaddas , Bukhari Sayed Muhammad Ata Ullah Shah , Khan Nasir , Shah Aamer Ali , Badshah Malik , Khan Samiullah 
Published: November 2023

AbstractFood demand is directly associated with the human population. Due to various plant diseases, there has been a reduction in crop yield. There is an extreme necessity to low such losses in crop yield to meet the rising demand for food. Novel and eco-friendly control approaches should be developed for combating bacterial diseases of crops. Recent control strategies that involve the usage of antibiotics or chemicals are no more effective because of resistance developed by bacterial species. Furthermore, the usage of such agents has proven to be not environmentally friendly. To overcome these issues, bacteriophages are used as an alternative solution. Phages are viruses that attack specific bacterial species, and within current years much consideration is received by them in controlling different diseases caused by bacteria. Phages can be used for controlling different crop-related diseases. Several phage-based products are accessible in the market. Compared to chemical control methods, phage biocontrol offers several advantages. Mixtures of phages can be employed to target pathogenic bacteria. Unlike chemical control strategies, phage mixtures can be readily adjusted to counter any potential resistance. This review summarizes the use of phages as a biocontrol agent against phytopathogens.
Epidural catheter migration: is aspiration enough? A case report
Authors: Murmu Ravi , Aditya A. , Tiwary P. K. , Lakra Ladhu , Kumar Tushar 
Published: November 2023

Abstract
Background
Local anesthetic agents are widely used drugs across the globe. Within their dosage range and appropriate location of administration, they are quite safe and effective. Rarely when given via intravascular route, local anesthetics can lead to life-threatening consequences.

Case presentation
Here, we present a case of a young male with an epidural catheter for femur surgery. The catheter was functioning quite well initially but later migrated in the intravascular route. When top-up was given with local anesthetics, the patient developed seizures which were managed promptly.

Conclusions
Inadvertent migration of catheter may occur during patient positioning or unwanted movements during surgery, but careful aspiration before every top-up and aspiration during every aliquot of top-up must be practiced.
Non-target embolic events during prostatic embolization with ethylene vinyl alcohol copolymer (EVOH)
Authors: Sédat Jacques , Arnoffi Paolo , Poirier Florent , Jamjoom Modhar , Raffaelli Charles , Colomb Frederic , Chau Yves 
Published: November 2023

Abstract
Background
This study evaluated nontarget embolization (NTE) during prostatic artery embolization (PAE) with ethylene vinyl alcohol copolymer (EVOH).

Results
Ten consecutive patients treated by PAE with EVOH for the presence of disabling benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) between June 22 and January 2023 were included in this prospective study. The inclusion criteria were as follows: LUTS attributed to BPH, LUTS duration ≥ 6 months, failure to respond to standard pharmacotherapy, IPSS > 18 or QoL score > 2, and prostate volume > 40 mL. Embolization was performed under general anaesthesia. According to established techniques, a microcatheter was positioned bilaterally within the feeding arteries, and EVOH was injected slowly under X-ray control. Unenhanced pelvic computed tomography scans were carried out before and after embolization to assess the NTE. The safety of the prostatic embolization procedure with EVOH was assessed by collecting adverse effects over 3 months of evaluation that included the International Prostate Symptom Score (IPSS) and quality of life (QoL) score.-up evaluations, occurring at 3, 6, and 12months, included International Prostate Symptom Score.
Bilateral PAE was technically successful in 9 patients, and unilateral injection was performed in one patient. The postoperative scanner showed a distribution of the embolization material in the two lobes of the prostate in all patients. The procedure time varied from 120 to 150 (mean: 132) minutes. Eight out of 10 patients developed pollakiuria within 24 h; none of the patients had postoperative pain. Two patients required catheterization for postoperative urinary retention. Catheters were removed successfully at the end of the first day for one of these patients and on the tenth day for the other. At the 3-month follow-up, patients showed significant improvement in the International Prostate Symptom Score (n = 10; mean = -11,5; P < 0.01) and quality of life score (n = 10; mean = -3,40; P < 0.01). Only one patient presented one asymptomatic muscular NTE.

Conclusions
PAE with EVOH is safe, effective, and associated with few NTEs and no postoperative pain. Prospective comparative studies with longer follow-ups are warranted.

Trial registration
IDRCB, 2021-AO29-56–35. Registered 27 May 2022,
http://clinicaltrials.gov/study/NCT05395299?cond=embolization&term&rank=1.
Alexithymia, resilience and suicidal ideation among patients with obsessive–compulsive disorder
Authors: Abd-Elhamed Mai Mohamed Elsayed , Hady Rehab Fathy Abdel , Mahmoud Shadia Fathy , Mohamed Bothina Elsayed Said 
Published: November 2023

AbstractBackgroundObsessive–compulsive disorder (OCD) is a psychiatric illness with a considerable risk of alexithymia, and suicide may make this risk worse. This study aimed to assess alexithymia, resilience, and suicidal ideation among patients with obsessive–compulsive disorder. A cross-sectional study was established at the psychiatric outpatient clinic at Zagazig University Hospitals in addition to Abbasyia Hospital for Mental Health in Cairo City. A purposive sample of 140 obsessive–compulsive patients. Five tools were used for data collection, including the socio-demographic questionnaire, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Toronto Alexithymia Scale (TAS-20), the Resilience Scale, and the Scale for Suicidal Ideation (SSI).ResultsThe study findings demonstrated that in excess of two-thirds of the studied subjects had mild obsessive–compulsive disorder, slightly more than two-thirds of them suffered from alexithymia, more than half of patients had a moderate level of resilience, and the majority of them had suicidal ideation. Patients’ obsessive–compulsive score was a statistically significant positive predictor for suicidal ideation.ConclusionsA positive and significant correlation was found between patients’ obsessive–compulsive scores and both alexithymia and suicidal ideation scores. Negatively significant correlations were found between resilience and each patient’s obsessive–compulsive score, alexithymia, and suicidal ideation. Therefore, it is recommended implementing longitudinal studies to establish the causality between OCD Sufferers’ resilience, alexithymia, and ideations of suicide.