bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardizing Physical Activity Monitoring in Patients With Degenerative Lumbar Disorders
Authors: Maldaner Nicolai , Tang Megan , Fatemi Parastou , Leung Chris , Desai Atman , Tomkins-Lane Christy , Zygourakis Corinna 
Published: November 2023

BACKGROUND AND OBJECTIVES:
Degenerative thoracolumbar disorders (DTDs) typically cause pain and functional impairment. However, little is known regarding the DTD impact on patient's real-life physical activity. The objective of this study is to validate a wearable measure of physical activity monitoring in patients with DTD and to create gender- and sex-specific performance thresholds that are standardized to the mean of a control population.

METHODS:
A commercially available smartwatch (Apple Watch) was used to monitor preoperative physical activity in patients undergoing surgery for DTD. Mean preoperative physical activity 2 weeks before the scheduled surgery was expressed as raw step count. Standardized z-scores were referenced to age- and sex-specific values of a control population from a large public database. Step counts were assessed for convergent validity with established patient-reported outcome measures, and impairment in activity was stratified into performance groups based on z-score cutoff values.

RESULTS:
Sixty-five patients (62% female) with a mean (±SD) age of 63.8 (±12.8) years had a mean preoperative daily step count of 5556 (±3978). Physical activity showed significant correlation with patient-reported outcome measures, including Oswestry disability index (r = −0.26, 95% CI: −0.47-0.01), 36-Item Short Form Survey Physical Component Summary score (r = 0.30, 95% CI: 0.06-0.51), and Patient-Reported Outcomes Measurement Information System Physical Function (r = 0.49, 95% CI: 0.27-0.65). “No,” “Mild,” “moderate,” and “severe impairment” in activity performance were defined as corresponding z-scores of >0, 0 to −0.99, −1 to −1.99, and ≤−2, accounting for 22%, 34%, 40%, and 5% of the study population. Each one-step category increase in activity impairment resulted in increased subjective disability as measured by the Oswestry Disability Index, 36-Item Short Form Survey Physical Component Summary, and Patient-Reported Outcomes Measurement Information System Physical Function (all P-values <.05).

CONCLUSION:
We establish the first wearable objective measure of real-life physical activity for patients with DTD, with the first age- and sex-adjusted standard scores to enable clinicians and researchers to set treatment goals and directly compare activity levels between individual patients with DTD and normal controls.
Corticosterone and immune responses to dehydration in squamate reptiles
Authors: Moeller Karla T. , Brashears Jacqueline A. , Davies Scott , Demare Guillaume , Smith Geoffrey D. , Brusch IV George A. , Simpson Richard K. , DeNardo Dale F. 
Published: November 2023

ABSTRACT
Many environments present some degree of seasonal water limitations; organisms that live in such environments must be adapted to survive periods without permanent water access. Often this involves the ability to tolerate dehydration, which can have adverse physiological effects and is typically considered a physiological stressor. While having many functions, the hormone corticosterone (CORT) is often released in response to stressors, yet increasing plasma CORT while dehydrated could be considered maladaptive, especially for species that experience predictable bouts of dehydration and have related coping mechanisms. Elevating CORT could reduce immunocompetence and have other negative physiological effects. Thus, such species likely have CORT and immune responses adapted to experiencing seasonal droughts. We evaluated how dehydration affects CORT and immune function in eight squamate species that naturally experience varied water limitation. We tested whether hydric state affected plasma CORT concentrations and aspects of immunocompetence (lysis, agglutination, bacterial killing ability and white blood cell counts) differently among species based on how seasonally water limited they are and whether this is constrained by phylogeny. The species represented four familial pairs, with one species of each pair inhabiting environments with frequent access to water and one naturally experiencing extended periods (&gt;30 days) with no access to standing water. The effects of dehydration on CORT and immunity varied among species. Increases in CORT were generally not associated with reduced immunocompetence, indicating CORT and immunity might be decoupled in some species. Interspecies variations in responses to dehydration were more clearly grouped by phylogeny than by habitat type.
Feasibility of Autofluorescence Using Overlay Imaging for the Detection of Parathyroid Glands: Defining Standards
Authors: Arikan Melisa , Hegazy Josef , Mertlitsch Sophie , Binter Teresa , Hargitai Lindsay , Scheuba Christian , Riss Philipp 
Published: November 2023

Abstract
Background
The aim of this study is to define standards for the use of near-infrared autofluorescence (NIRAF)-based overlay imaging via EleVision IR (Medtronic, Dublin, Ireland) and to evaluate its clinical applicability.

Patients and Methods
This prospective study included 189 patients who had undergone open thyroid and/or parathyroid surgery and in whom EleVision IR was applied to visualize at least one parathyroid gland (PG) between January 2021 and May 2022 in a tertiary referral care center. Whether the PGs were first localized by the surgeon or by overlay imaging was noted. Handling of the device, application time and duration, distance, infrared intensity (IR%), and the angle of each measurement were analyzed. In thyroidectomies, the specimens were subsequently scanned for further PGs. NIRAF patterns and intensities were described.

Results
Overall, 543 PGs were analyzed in 158 (83.6%) surgeries of thyroid glands (TGs) and in 49 (25.9%) surgeries for hyperparathyroidism. In 111 (58.7%) patients, identical numbers of PGs were detected by the surgeon and by overlay imaging. While a larger number of PGs was identified by the surgeon in 48 (25.4%) patients, overlay imaging served to detect more PGs in 30 (15.9%) cases. In four (2.1%) patients, PGs were visualized post-thyroidectomy due to their autofluorescence on the specimen. NIRAF-based overlay imaging was applied to depict the PGs early on after exposure by the surgeon. The ideal distance for the measurement ranged between 8 and 12 cm with an angle of 90° and a mean IR% of 34.5% (± 17.6).

Conclusions
Considering the standard operating procedures, NIRAF-based overlay imaging can be used as an adjunct tool for intraoperative localization.
Lived experiences of women who survived from pre-eclampsia and eclampsia in public hospitals of Shashemene Town, Oromia Region, Ethiopia: a qualitative study.
Authors: Gebeyehu Negeso , Urgessa Aman , Yohannes Daniel , Yalew Aster , Ahmed Muluneh , Admasu Meron 
Published: November 2023

Objective: The main purpose of this study was to explore experiences of women who survived pre-eclampsia and eclampsia in Shashemene referral hospital and Melka Oda general hospital, 2021. Design: An institution-based exploratory qualitative study with a descriptive phenomenological study design Setting: The present study was conducted in Shashemene referral hospital and Melka Oda general hospital from March 03 to May 18, 2021. Participants: A total of 17 individual in-depth interviews (IDIs) were conducted with women who experienced and survived pre-eclampsia and eclampsia. Data were analyzed through thematic analysis using Atlas-ti software. Result: The present study revealed that women’s level of awareness on raised blood pressure and or convulsion occurring during pregnancy was poor. Barriers that limit pregnant women from getting treatment at the earliest point included misconception, lack of insight, failure to accept counseling from health care providers, low income, and influence from husbands. Discussions with the women in this study showed that these mothers were not counseled on danger signs during antenatal care check-ups. Almost all of the women were very concerned and frustrated due to their diagnosis. Conclusions: Women’s awareness of pre-eclampsia and eclampsia was poor and antenatal care was not offered as per expected quality. Improving awareness of hypertensive disorders in pregnancy and enhancing the quality of antenatal care is essential.
The relationship between cotinine levels in the blood with glutathione, and malondialdehyde levels of smokers: a systematic review and meta-analysis
Authors: Tualeka Abdul Rohim , Jalaludin Juliana , Sopian Nor Ashikin , Aziz Mohd Yusmaidie , Rahmawati Pudji , Ahsan Ahsan , Novianti Salsabila 
Published: November 2023

Background: Smoking is associated with increased oxidative stress and inflammation, which can lead to the development of various diseases. Blood cotinine level is a reliable biomarker of nicotine exposure, and glutathione and malondialdehyde levels are biomarkers of oxidative stress and inflammation. Several studies have been conducted to investigate the relationship between blood cotinine levels, glutathione levels, and malondialdehyde levels in smokers. Therefore, we conducted this meta-analysis to investigate the association. Methods: All cross-sectional and case-control studies published in the last 20 years (2003-2023) were identified by searching electronic databases such as PubMed, Science Direct, DOAJ, ResearchGate, and Google Scholar. Inclusion criteria were studies that focused on the relationship between blood cotinine levels, glutathione levels, and malondialdehyde levels in smokers, while qualitative research type, non-human studies, and studies that included variable measurement parameters saliva, urine, and hair were excluded. Results: Six case-control and cross-sectional studies with 333 participants who were smokers and 267 participants who were non-smokers were included in the meta-analysis. There was a significant association between blood cotinine levels with malondialdehyde levels in smokers (MD = 115.37, p 0.0004, 95% CI = 51.92 to 178.82). The mean difference is positive indicating that the average blood levels of cotinine in smokers tend to be higher than malondialdehyde levels in smokers. Conclusions: Based on our meta-analysis, blood cotinine levels were significantly associated with malondialdehyde levels in smokers. Smoking can increase blood cotinine levels of smokers compared with that of non-smokers.
Network meta-analysis of treatments for perineal extramammary paget’s disease: Focusing on performance of recurrence prevention
Authors: Yuan Xiaobin , Xue Ruizhi , Cao Xiaoming 
Published: November 2023

Introduction
Perineal extramammary paget’s disease (EMPD) is characterized with high recurrence rate. Although numerous therapeutic measures for this disease have been reported so far, it is unknown whether there is significant difference in their recurrence-preventing efficiency. This study aims to compare the recurrence outcomes of reported perineal EMPD treatments.

Methods
We searched public databases of for published studies concerning perineal EMPD treatments. After screening by inclusion and exclusion criteria, we extracted the data relevant to recurrence rate, and conducted network meta-analysis (NMA) by using Bayesian random-effects approach.

Results
Our analysis included 29 previous studies (involving both male and female patients) and 11 treatment designs which are wide local excision (WLE), local excision (LE), Mohs micrographic surgery (MMS), radiotherapy (RT), radical vulvectomy (RV), photodynamic therapy (PDT), lasers (LS), imiquimod, and WLE+RT, WLE+PDT, WLE+LS. Comparing with WLE, the MMS showed significant advantage in reducing recurrence [OR: 0.18 (0.03–0.87)], while none of the rest treatments has statistically significant results. After removing outlier studies, MMS still has the significant advantages [OR: 0.35 (0.11–0.82)], and LE turned to be the treatment with worst performance [OR: 13 (2.50–110)]. Covariance analysis of follow-up length, gender differences, and lesion locations indicated only short follow-up time could affect the recurrence statistics, which tend to conceal the real differences. Funnel plot demonstrated there is no significant small study effect.

Conclusion
MMS has the best performance on reducing perineal EMPD recurrence, while LE exhibits the worst capability in such regard. Recurrence-preventing abilities of other treatments have no significant difference between each other.
El concepto de dialéctica en Marx
Authors: López Arnal Salvador , Fernández Buey Francisco , Sarrión Andaluz José 
Published: November 2023

El presente artículo recoge una conferencia inédita. Por un lado, el autor se centra en examinar los usos impropios de la noción de dialéctica, rechazando su concepción como lógica alternativa a la formal, como ciencia o como método en un sentido estricto. Por otro lado, muestra una caracterización de la dialéctica como una «metódica» en sentido amplio que se propone captar totalidades concretas en su despliegue desde un punto de vista materialista, histórico y crítico, con finalidades emancipatorias, cuya cientificidad sólo podría admitirse si se entiende en un sentido subordinado.
Glosa do wyroku Wojewódzkiego Sądu Administracyjnego w Gliwicach z dnia 22 stycznia 2015 r. (sygn. I SA/Gl 1070/14)
Authors: Owoc Jędrzej , Wiśniewski Krzysztof 
Published: November 2023

Przedmiotem glosy jest wyrok Wojewódzkiego Sądu Administracyjnego w Gliwicach dotyczący pojęcia dochodów z pracy małoletnich, użytego w art. 7 ust. 1 Ustawy z dnia 26 lipca 1991 r. o podatku dochodowym od osób fizycznych. Autorzy zgadzają się z rozstrzygnięciem, uważając jednak, że przeprowadzona przez sąd argumentacja jest niewystarczająca. Kompleksowa wykładnia przepisu prowadzi autorów do wniosku, że kryterium wyłączenia dochodów małoletnich dzieci spod kumulacji z dochodami rodziców jest samodzielność w ich uzyskiwaniu. W konsekwencji przyjmują, że pojęcie pracy w art. 7 ust. 1 omawianej ustawy powinno być rozumiane wąsko.
It isn’t sloppy language: exploring the discourse of Village English
Authors: Marlow Patrick Edward , Martelle Wendy Whitehead , Webster Joan Parker , Kealy Kelly 
Published: November 2023

Abstract
In Alaska, as elsewhere in the United States, standardized American English is privileged over both local varieties of English and Indigenous languages. This privileged position is maintained, in part, through a deficit model of language acquisition and a model of school success which locates the source of underachievement among K-12 students within the child rather than within the broader sociopolitical context of school and schooling. Using a critical participatory action research approach, this article examines a single graduate course for K-12 teachers intended to address ideologies of linguistic deficit and demonstrate that the varieties of English spoken by adults and children in Southwest Alaska are systematic and rule-governed. Data are analyzed in terms of trajectories of learning, focusing on three distinct points within this trajectory: Pre-course questionnaire, Mid-point questionnaire and post-course artifacts (e.g., final projects for the master’s degree). Through the lens of discourse analysis (Gee, James Paul. 2010. An introduction to discourse analysis: Theory and method, 3rd edn. New York, NY: Routledge), we illustrate and discuss the tensions inherent in shifting discourse models as the teachers contend with course content that challenges broadly accepted explanations for school underachievement.
Read for me: developing a mobile based application for both visually impaired and illiterate users to tackle reading challenge
Authors: Alfayez Zainab Hameed , Alfayez Batool Hameed , Abdul-Samad Nahla Hamad 
Published: November 2023

AbstractIn recent years, there have been several attempts to help visually impaired and illiterate people to overcome their reading limitations through developing different applications. However, most of these applications are based on physical button interaction and avoid the use of touchscreen devices. This research mainly aims to find a solution that helps both visually impaired and illiterate people to read texts present in their surroundings through a touchscreen-based application. The study also attempts to discover the possibility of building one application that could be used by both type of users and find out whether they would use it in the same efficiency. Therefore, a requirements elicitation study was conducted to identify the users’ requirements and their preferences and so build an interactive interface for both visually impaired and illiterate users. The study resulted in several design considerations, such as using voice instructions, focusing on verbal feedback, and eliminating buttons. Then, the reader mobile application was designed and built based on these design preferences. Finally, an evaluation study was conducted to measure the usability of the developed application. The results revealed that both sight impaired and illiterate users could benefit from the same mobile application, as they were satisfied with using it and found it efficient and effective. However, the measures from the evaluation sessions also reported that illiterate users had used the develop app more efficiently and effectively. Moreover, they were more satisfied, especially with the application’s ease of use.
Hydrogen production and conversion to chemicals: a zero-carbon puzzle?
Authors: Marchionna Mario 
Published: November 2023

Abstract
Hydrogen is currently used as an intermediate product in the chemical (mostly ammonia and methanol) and refining industries. It is produced mostly from natural gas in large scale plants using steam methane reforming, a very mature technology. Hydrogen produced from natural gas has a high carbon footprint, considering that about 6–9 tons of CO2 are co-produced (and emitted to the atmosphere) per ton of produced hydrogen, depending on natural gas composition. For this reason, hydrogen produced from fossil fuels is nowadays named as “grey” hydrogen. The current production of hydrogen is responsible of about 2.5 % of CO2 emissions worldwide. For hydrogen remaining in business, and then becoming a factor in the energy transition period and later, decarbonizing its production is a must. Partially decarbonized hydrogen produced from fossil fuels, through CO2 capture, is named “blue” hydrogen. A completely different path is followed for the production of fully decarbonized, or “green” hydrogen. This path is already commercially available, though on a smaller scale than required for wide industrial application. It is the electrolysis of water, i.e. the use of electric power from renewable sources to break the water molecule into its constituent hydrogen and oxygen. Pros & cons of these two options will be critically examined.
Efeitos do capital social em ambidestria organizacional
Authors: Silva Matilde Dallagassa da , Popadiuk Silvio 
Published: November 2023

São os recursos tangíveis e intangíveis responsáveis por garantir uma vantagem competitiva sustentável para as empresas. Logo o capital social, fruto das relações intra e inter organizacionais organizacional e a ambidestria organizacional envolvendo a exploração e a explotação de conhecimentos são fatores de sucesso para o desenvolvimento e sobrevivência das organizações. Entretanto, pouco se têm conhecimento com relação aos efeitos empíricos que as relações sociais promovem na ambidestria. Com este estudo buscou-se avaliar a influência das dimensões estrutural, relacional e cognitiva do capital social na estratégia de ambidestria das organizações. Para isso, aplicou-se uma survey com 93 respondentes e realizou-se a análise mediante a utilização de equações estruturais. Os resultados apontaram que, apesar da teoria apresentar que as três dimensões são inerentes ao capital social, somente a dimensão cognitiva influencia a ambidestria organizacional. Portanto, foi possível perceber que os objetivos e a cultura compartilhada entre os membros de uma organização, são os fatores mais importantes na manutenção e gestão da ambidestria.
Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease
Authors: Weisser Ivan , Eckberg Kara , D'Amico Stephen , Buttram Daniel , Aboudehen Karam 
Published: November 2023

Significance Statement
Long noncoding RNAs (lncRNAs) are a class of nonprotein coding RNAs with pivotal functions in development and disease. They have emerged as an exciting new drug target category for many common conditions. However, the role of lncRNAs in autosomal dominant polycystic kidney disease (ADPKD) has been understudied. This study provides evidence implicating a lncRNA in the pathogenesis of ADPKD. We report that Hoxb3os is downregulated in ADPKD and regulates mammalian target of rapamycin (mTOR)/Akt pathway in the in vivo mouse kidney. Ablating the expression of Hoxb3os in mouse polycystic kidney disease (PKD) activated mTOR complex 2 (mTORC2) signaling and exacerbated the cystic phenotype. The results from our study provide genetic proof of concept for future studies that focus on targeting lncRNAs as a treatment option in PKD.

Background
ADPKD is a monogenic disorder characterized by the formation of kidney cysts and is primarily caused by mutations in two genes, PKD1 and PKD2.

Methods
In this study, we investigated the role of lncRNA Hoxb3os in ADPKD by ablating its expression in the mouse.

Results

Hoxb3os-null mice were viable and had grossly normal kidney morphology but displayed activation of mTOR/Akt signaling and subsequent increase in kidney cell proliferation. To determine the role of Hoxb3os in cystogenesis, we crossed the Hoxb3os-null mouse to two orthologous Pkd1 mouse models: Pkhd1/Cre; Pkd1

F/F
(rapid cyst progression) and Pkd1

RC/RC
(slow cyst progression). Ablation of Hoxb3os exacerbated cyst growth in both models. To gain insight into the mechanism whereby Hoxb3os inhibition promotes cystogenesis, we performed western blot analysis of mTOR/Akt pathway between Pkd1 single-knockout and Pkd1-Hoxb3os double-knockout (DKO) mice. Compared with single-knockout, DKO mice presented with enhanced levels of total and phosphorylated Rictor. This was accompanied by increased phosphorylation of Akt at Ser473, a known mTORC2 effector site. Physiologically, kidneys from DKO mice displayed between 50% and 60% increase in cell proliferation and cyst number.

Conclusions
The results from this study indicate that ablation of Hoxb3os in mouse PKD exacerbates cystogenesis and dysregulates mTORC2.