bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
Authors: Suppa Antonio , Asci Francesco , Costantini Giovanni , Bove Francesco , Piano Carla , Pistoia Francesca , Cerroni Rocco , Brusa Livia , Cesarini Valerio , Pietracupa Sara , Modugno Nicola , Zampogna Alessandro , Sucapane Patrizia , Pierantozzi Mariangela , Tufo Tommaso , Pisani Antonio , Peppe Antonella , Stefani Alessandro , Calabresi Paolo , Bentivoglio Anna Rita , Saggio Giovanni ,   Lazio DBS Study Group
Published: October 2023

IntroductionDeep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of PD patients with STN-DBS.Materials and methodsIn a cross-sectional study, we enrolled 108 controls and 101 patients with PD. The cohort of PD was divided into two groups: the first group included 50 patients with STN-DBS, and the second group included 51 patients receiving the best medical treatment. The voices were clinically evaluated using the Unified Parkinson's Disease Rating Scale part-III subitem for voice (UPDRS-III-v). We recorded and then analyzed voices using specific machine-learning algorithms. The likelihood ratio (LR) was also calculated as an objective measure for clinical-instrumental correlations.ResultsClinically, voice impairment was greater in STN-DBS patients than in those who received oral treatment. Using machine learning, we objectively and accurately distinguished between the voices of STN-DBS patients and those under oral treatments. We also found significant clinical-instrumental correlations since the greater the LRs, the higher the UPDRS-III-v scores.DiscussionSTN-DBS deteriorates speech in patients with PD, as objectively demonstrated by machine-learning voice analysis.
Proof-of-concept for characterization of neurodegenerative disorders utilizing two non-REM sleep biomarkers
Authors: Levendowski Daniel J. , Neylan Thomas C. , Walsh Christine M. , Tsuang Debby , Salat David , Hamilton Joanne M. , Lee-Iannotti Joyce K. , Berka Chris , Mazeika Gandis , Boeve Bradley F. , St. Louis Erik K. 
Published: October 2023

Study objectiveThis proof-of-concept study aimed to determine whether the combined features of two non-rapid eye movement (NREM) sleep biomarkers acquired predominantly in-home could characterize different neurodegenerative disorders.MethodsSleep spindle duration and non-REM hypertonia (NRH) were evaluated in seven groups including a control group (CG = 61), and participants with isolated REM sleep behavior disorder (iRBD = 19), mild cognitive impairment (MCI = 41), Parkinson disease (PD = 16), Alzheimer disease dementia (ADem = 29), dementia with Lewy Bodies or Parkinson disease dementia (LBD = 19) and progressive supranuclear palsy (PSP = 13). One-way analysis of variance (ANOVA), Mann–Whitney U, intra-class (ICC) and Spearman ranked correlations, Bland–Altman plots and Kappa scores, Chi-square and Fisher exact probability test, and multiple-logistic regression were focused primarily on spindle duration and NRH and the frequencies assigned to the four normal/abnormal spindle duration/NRH combinations.ResultsANOVA identified group differences in age, sleep efficiency, REM, NRH (p &lt; 0.0001) and sleep time (p = 0.015), Spindle duration and NRH each demonstrated good night-to-night reliabilities (ICC = 0.95 and 0.75, Kappa = 0.93 and 0.66, respectively) and together exhibited an association in the PD and LBD groups only (p &lt; 0.01). Abnormal spindle duration was greater in records of PSP (85%) and LBD (84%) patients compared to CG, MCI, PD and ADem (p &lt; 0.025). Abnormal NRH was greater in PSP = 92%, LBD = 79%, and iRBD = 74% compared to MCI = 32%, ADem = 17%, and CG = 16% (p &lt; 0.005).The combination biomarker normal spindle duration/normal NRH was observed most frequently in CG (56%) and MCI (41%). ADem most frequently demonstrated normal spindle duration/normal NRH (45%) and abnormal spindle duration/normal NRH (38%). Normal spindle duration/abnormal NRH was greatest in iRBD = 47%, while abnormal spindle duration/abnormal NRH was predominant in PSP = 85% and LBD = 74%.ConclusionThe NREM sleep biomarkers spindle duration and NRH may be useful in distinguishing patients with different neurodegenerative disorders. Larger prospective cohort studies are needed to determine whether spindle duration and NRH can be combined for prodromal assessment and/or monitoring disease progression.
Effect of partially hydrolyzed synbiotic formula milk on weight gain of late preterm and term infants—a multicenter study
Authors: Sahin Suzan , Buyuktiryaki Mehmet , Okur Nilufer , Akcan Abdullah Baris , Deveci Mehmet Fatih , Yurttutan Sadik , Gunes Sezgin , Anik Ayse , Ozdemir Ramazan , Uygur Ozgun , Oncel Mehmet Yekta 
Published: October 2023

IntroductionData on the effectiveness of hydrolyzed infant formula containing both pre- and probiotics (synbiotic formula) on the growth of infants is still scarce. This retrospective study was designed to evaluate the effect of a partially hydrolyzed synbiotic formula on growth parameters and the possible occurrence of major gastrointestinal adverse events or morbidities in infants born via cesarean section (C-section) delivery.MethodsC-section-delivered term and late preterm infants who received either partially hydrolyzed synbiotic formula, standard formula, or maternal milk and followed at seven different hospitals from five different regions of Turkey, during a 1-year period with a minimum follow-up duration of 3 months were evaluated retrospectively. All the included infants were evaluated for their growth patterns and any kind of morbidity such as diarrhea, constipation, vomiting, infection, or history of hospitalization.ResultsA total of 198 infants (73 in the human milk group, 61 in the standard formula group, and 64 in the partially hydrolyzed synbiotic formula group) reached the final analysis. The groups were similar regarding their demographic and perinatal characteristics. No difference was observed between the three groups regarding gastrointestinal major side effects. Growth velocities of the infants in the human milk and partially hydrolyzed synbiotic formula groups during the first month of life were similar whereas the weight gain of infants in the standard formula group was significantly less than these two groups (p &lt; 0.001). Growth velocities were similar among the three groups between 1st and 3rd months of age.DiscussionA partially hydrolyzed synbiotic formula provided better weight gain in late-preterm and term infants who were delivered via C-section delivery compared to the standard formula during the first month of life. This weight gain was similar to the infants receiving exclusively human milk. This difference was not observed in length and head circumference gain. No difference was observed in any of the parameters during the 1st–3rd months of age. Specially formulated partially hydrolyzed synbiotic formulas may reverse at least some of the negative impacts of C-section delivery on the infant and help to provide better growth, especially during the early periods of life.
Ecological factors associated with child sexual abuse among 15- to 17-year-old adolescents in mainland China: implications for intervention
Authors: Fu Guochen , Xu Yao , Pan Mingliang , Zhang Ziyuan , Zhang Hudie , Zhao Youxiong , Lin Lu , Ye Zijie , Liu Jiajun , Lan Fangjun , Luo Dongsheng , Wang Siyi , Zhu Bangzheng , Liao Xinyu , Hong Mengsi , Chen Jilun , Li Zihao , Yang Gaoming , Zhao Ziyuan , Liu Yusi , Ruan Fang , Yang Chunyan , Wang Junfang 
Published: October 2023

BackgroundChild sexual abuse is a major public health problem with adverse consequences for victims’ physical, mental, and reproductive health. This cross-sectional study aimed to determine the prevalence of child sexual abuse and its associated factors among 15- to 17-year-old adolescents in mainland China.MethodsFrom September 8, 2019 to January 17, 2020, a total of 48,660 participants were recruited by 58 colleges and universities across the whole country to complete the self-administered, structured, online questionnaire. This analysis was restricted to 3,215 adolescents aged between 15 and 17 years in mainland China. Chi-square tests and multivariate Logistic regression analyses were performed to identify individual, relationship, and community factors associated with child sexual abuse.ResultsThe overall prevalence of child sexual abuse was 12.0%. More specifically, 13.0% of girls and 10.6% of boys reported that they were sexually abused prior to 18 years of age. At the individual level, being female, sexual minority identity, younger age, and higher levels of knowledge, skills and self-efficacy regarding condom use were significantly related to increased odds of reporting sexual abuse. At the relationship and community level, adolescents from disrupted families and those entering into a marriage, having casual sexual partners, and having first intercourse at a younger age were more likely to report sexual abuse. On the contrary, those who had never discussed sex-related topics with their family members at home and were offered school-based sexuality education later (vs. earlier) were less likely to report sexual abuse.ConclusionMultilevel prevention programs and strategies, including targeting adolescents with high-risk characteristics, educating young children and their parents about child sexual abuse prevention and optimizing the involvement of parents, school, community, society and government in comprehensive sexuality education, should be taken to reduce child sexual abuse among 15- to 17-year-old adolescents.
Bromoform exposure is associated with non-melanoma skin cancer: evidence from NHANES 2011–2020
Authors: Gao Mingnan , Guo Han , Han Jingjing , Liu Jinhua , Hou Yinglong , Wang Zimao , Yang Zheng , Wang Qiying 
Published: October 2023

BackgroundNon-melanoma skin cancer (NMSC) is a prevalent skin malignancy. It has been indicated in many studies that trihalomethanes (THMs) exposure has a strong association with tumors but has not been associated with NMSC. Our investigation aims to explore the association between THMs exposure and NMSC.MethodsCross-sectional data from the 2011 to 2020 National Health and Nutrition Examination Survey (NHANES) was collected. Poisson regression and subgroup analyses were performed to evaluate the association between individual THMs components and NMSC. Fitted smoothing curves and generalized additive models were also used.ResultsThis study involved 5,715 individuals, 98 (1.7%) of whom self-reported NMSC. After adjusting for covariates, Poisson regression showed that higher blood TBM levels were associated with an increased likelihood of NMSC (OR = 1.03; 95% CI: 1.01–1.05, p = 0.002). However, the correlation between the blood levels of TCM, DBCM, and BDCM and the likelihood of NMSC was not statistically significant (all p &gt; 0.05). Subgroup analysis and interaction tests showed no significant differences between blood TBM concentration and the likelihood of NMSC, indicating that age, gender, and race were significantly independent of this positive association (all p &lt; 0.05).ConclusionsOur results implied that among adults older than 65 years old in the U.S., elevated blood TBM concentrations were positively associated with NMSC. More prospective investigations are required to validate this relationship with the early prevention of NMSC.
Pan-India influenza-like illness (ILI) and Severe acute respiratory infection (SARI) surveillance: epidemiological, clinical and genomic analysis
Authors: Potdar Varsha , Vijay Neetu , Mukhopadhyay Labanya , Aggarwal Neeraj , Bhardwaj Sumit Dutt , Choudhary Manohar Lal , Gupta Nivedita , Kaur Harmanmeet , Narayan Jitendra , Kumar Prabhat , Singh Harpreet , Abdulkader Rizwan Suliankatchi , Murhekar Manoj , Mishra Meena , Thangavel Sundararajan , Nagamani K. , Dhodapkar Rahul , Fomda Bashir Ahmad , Varshney Umesh , Majumdar Agniva , Dutta Shanta , Vijayachari P. , Turuk Jyotirmayee , Majumdar Tapan , Sahoo Ganesh Chandra , Pandey Krishna , Bhargava Anudita , Negi Sanjay Singh , Khatri Prabhat K. , Kalawat Usha , Biswas Debasis , Khandelwal Neeta , Borkakoty Biswajyoti , Manjushree S. , Singh Mini P. , Iravane Jyoti , Kaveri K. , Shantala G. B. , Brijwal Megha , Choudhary Aashish , Dar Lalit , Malhotra Bharti , Jain Amita ,   ILI-SARI Surveillance Team
Published: October 2023

BackgroundOver time, COVID-19 testing has significantly declined across the world. However, it is critical to monitor the virus through surveillance. In late 2020, WHO released interim guidance advising the use of the existing Global Influenza Surveillance and Response System (GISRS) for the integrated surveillance of influenza and SARS-CoV-2.MethodsIn July 2021, we initiated a pan-India integrated surveillance for influenza and SARS-CoV-2 through the geographically representative network of Virus Research and Diagnostic Laboratories (VRDLs) across 26 hospital and laboratory sites and 70 community sites. A total of 34,260 cases of influenza-like illness (ILI) and Severe acute respiratory infection (SARI) were enrolled from 4 July 2021 to 31 October 2022.FindingsInfluenza A(H3) and B/Victoria dominated during 2021 monsoon season while A(H1N1)pdm09 dominated during 2022 monsoon season. The SARS-CoV-2 “variants of concern” (VoC) Delta and Omicron predominated in 2021 and 2022, respectively. Increased proportion of SARI was seen in extremes of age: 90% cases in &lt; 1 year; 68% in 1 to 5 years and 61% in ≥ 8  years age group. Approximately 40.7% of enrolled cases only partially fulfilled WHO ILI and SARI case definitions. Influenza- and SARS-CoV-2-infected comorbid patients had higher risks of hospitalization, ICU admission, and oxygen requirement.InterpretationThe results depicted the varying strains and transmission dynamics of influenza and SARS-CoV-2 viruses over time, thus emphasizing the need to continue and expand surveillance across countries for improved decision making. The study also describes important information related to clinical outcomes of ILI and SARI patients and highlights the need to review existing WHO ILI and SARI case definitions.
Risky sexual behaviors among orphaned youth in South Africa: findings of the 2017 population-based household survey
Authors: Vondo Noloyiso , Mabaso Musawenkosi , Mehlomakulu Vuyelwa , Sewpaul Ronel , Davids Adlai , Ndlovu Philisiwe , Sekgala Derrick , Shandu Londiwe , Moyo Sizulu 
Published: October 2023

IntroductionIn sub-Saharan Africa, evidence shows that orphaned youth are exposed to more risky sexual behaviors than non-orphaned peers, which increases the chances of contracting HIV and other sexually transmitted infections. The fast rises in the prevalence of orphanhood are a result of the HIV/AIDS epidemic.MethodologyThe data for this secondary analysis were collected through a cross-sectional, multi-stage, stratified, cluster randomized sampling design. Multivariable backward stepwise logistic regression analysis was fitted to determine the factors associated with risky sexual behaviors among male and female adolescents and youth aged 12–24 years.ResultsOf 2,556 orphaned participants, 18.3% (95% CI: 14.3–23.0) had two or more sexual partners in the last 12 months, 31.3% (95% CI: 26.3–36.6) reported no condom use at last sex, and 98.3% (95% CI: 96.6–99.2) reported no consistent condom use. The likelihood of reporting multiple sexual partnerships was significantly lower among female adolescents, those residing in rural formal/farm areas, and those who reported sexual debut at age 15 years and was higher among those who reported sexual partners 5 years and older than their age group. The odds of not using a condom at last sex were significantly higher among female adolescents and those who perceived themselves as being at high risk of HIV infection and were significantly lower among those who had sexual debut at age 15 years and older.DiscussionThe findings suggest that there is a need for sexual risk-reduction strategies targeted at orphans, especially male orphans and those residing in urban areas. Such efforts should include behavior change interventions for delaying the age of sexual debut, changing HIV risk perception, mitigating multiple sexual partnerships, age-disparate sexual relationships, and enhancing condom use.
Translanguaging in EFL Classroom at A Private University in South Sulawesi
Authors: Muis Satriyana , Salija Kisman , Nur Sahril , Sakkir Geminastiti 
Published: October 2023

This research aims to investigate translanguaging in an EFL classroom. Several researchers have researched translanguaging (1) Sahib (2019), (2) Saputra (2014), (3) Rabbidge (2019), Yuvayapan (2019), Aoyama (2020), and Rasmin & Nur (2023). Nevertheless, in south Sulawesi, especially Palopo still not enough. Hence, this research tries to see the practice of translanguaging in EFL classrooms. This research focused on exploring the reasons lecturers conduct translanguaging, the way lecturers conduct translanguaging in EFL classrooms, and the lecturers’ and students’ perceptions toward translanguaging. The participants of this research were two English lecturers and fifteen students in the fourth-semester English education department at Cokroaminoto Palopo University. This research applied a qualitative method, the instruments were classroom observation and interview. The result of the observation and interview was transcribed and analyzed based on the research focus. The findings of this research were the reasons lecturers conducted translanguaging the first to make their English teaching in the classroom effective and the second to make the students understand the teaching and learning material well. The way lecturers conduct translanguaging is based on the situation of the students. If the students do not understand what the lecturers explain in English, they will use translanguaging in the classroom to make the teaching and learning process run smoothly. The lecturers express a positive perception toward translanguaging which is reflected through ten positive comments about the use of translanguaging in the EFL classroom. The students also give a positive perception of the five questions that have been asked. The students can feel the benefit of the use of translanguaging in the EFL classroom.
Desaprender para aprender sobre complejidad
Authors: Samayoa Santiago Julio Armando 
Published: October 2023

PROBLEMA: Con la creciente incertidumbre y complejidad del mundo, surge la pregunta: ¿Cómo puede la educación adaptarse y evolucionar para incorporar el pensamiento complejo y enfrentar de manera efectiva la creciente incertidumbre y complejidad del mundo moderno? OBJETIVO: Desarrollar estrategias educativas que integren el pensamiento complejo para mejorar la capacidad de los estudiantes para navegar y comprender la creciente incertidumbre y complejidad del mundo moderno. MÉTODO: Para lograr esto, se revisó variedad de fuentes bibliográficas centradas en la teoría de sistemas complejos y el pensamiento complejo. Posteriormente de adquirir un entendimiento de dichas teorías, se realizó un análisis crítico para formular mi propia opinión y reacción. RESULTADOS: El estudio reveló el valor de la interdisciplinariedad, la importancia de la teoría de sistemas complejos en la educación, el reconocimiento de la importancia de la historia y la necesidad de abordar la complejidad con un enfoque integrado. REFLEXIÓN INCONCLUSA: la importancia del pensamiento complejo y la teoría de sistemas complejos en nuestra comprensión del mundo. La complejidad, aunque difícil de definir, nos impulsa hacia enfoques interdisciplinarios para abordar los problemas y fenómenos modernos, que están cada vez más marcados por la incertidumbre y la imprevisibilidad. La educación, por lo tanto, debe adaptarse e integrar estas teorías para preparar a los estudiantes para un mundo en constante cambio.
Analisis Postur Kerja Karyawan Pada Proses Pemotongan Kain Di UD Wijaya
Authors: Ardiansyah Ardin , Andesta Deny 
Published: October 2023

UD. Wijaya is manufacturing bag products that was established in 2016. Currently, cloth cutting activities at UD Wijaya still use human labor manually. The cloth cutting activities are carried out with the work position bent and the legs bend so that workers often feel pain in the waist, back, calves, knees, ankles, and soles of the feet. In addition, there are no facilities in the form of tables or chairs for cutting places. Activities at UD wijaya is carried out for analysis of the worker's posture to find out the complaints felt in the workers' muscles in the cutting section and can provide recommendations for improving work methods or tools to minimize the risk of worker injury. Based on the analysis of employee work posture in the fabric cutting process using the Rapid Entire Body Assessment (REBA) method, a high REBA score of 9 was obtained and corrective action was needed. If the posture is not corrected immediately, then the workers may have injuries of Musculoskeletal Disorders (MSDs) in the long and short term. The working posture repairment suggested is by making tools in the form of chairs and work tables with the anthropometric data of workers.
Felicidad laboral, bienestar laboral y subjetividad emocional: una mirada desde la complejidad humana
Authors: Andrade Molinares Sonia Mercedes 
Published: October 2023

Este estudio se inserta dentro de las grandes temáticas de la psicología laboral, a su vez forma parte de una investigación asociada a una residencia postdoctoral en Ciencias Humanas de la Universidad de los Andes a través del HUMANIC. El objetivo fundamental del estudio responde a ¿cuál es la percepción que se tiene de la felicidad desde la dinámica del bienestar laboral y la subjetividad emocional? La ruta metodológica se fundó a partir del enfoque cualitativo, bajo la aplicación de una entrevista en profundidad a quince informantes clave, todos trabajadores y con edades comprendidas entre los 18 y 44 años. La recolección de evidencias y su análisis dejó al descubierto la presencia de una insatisfacción concomitante a nivel laboral y una escasa comprensión de la importancia y trascendencia de la felicidad en los sitios de trabajo, así como la necesaria presencia de nuevas formas de motivación en los sitios de trabajo
«Do nieba? Bluźnisz daremnie»: Faust – Marlowe – Grotowski
Authors: Kosiński Dariusz 
Published: October 2023

Artykuł omawia spektakl Tragiczne dzieje doktora Fausta według Christophera Marlowe'a w reżyserii Jerzego Grotowskiego wystawiony w Teatrze Laboratorium w Opolu (premiera 23 kwietnia 1963 roku). Spektakl zasłynął przede wszystkim za sprawą wybitnej kreacji Zbigniewa Cynkutisa w roli tytułowej, a także scenografii Jerzego Gurawskiego. Był to również pierwszy spektakl Grotowskiego, który zdobył międzynarodowe uznanie. Do tej pory jednak nie poświęcono wiele uwagi jego dramaturgii i znaczeniu jako autonomicznego dzieła artystycznego, zamiast tego postrzegano go głównie jako krok na drodze do bardziej dojrzałego teatru Grotowskiego. Rekonstruując i opowiadając poszczególne sceny w porządku chronologicznym, autor przedstawia własną interpretację każdej z nich oraz spektaklu jako całości. W tym procesie można odnaleźć niemal skandaliczne skojarzenia wielkich tematów historycznych i etycznych (np. teologii po Holokauście) z osobistymi zmaganiami z prywatnymi zahamowaniami i intymnymi doświadczeniami. To właśnie dzięki takim skojarzeniom Tragiczne dzieje doktora Fausta zostały nazwane "misterium zgrozy i urzeczenia".