bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of C-reactive Protein and Procalcitonin in Predicting the Occurrence of Pancreatic Fistula in Patients who Underwent Laparoscopic Pancreaticoduodenectomy: a Retrospective Study
Authors: Al Hussan Maher , Qiao Shishi , Abuheit Ezaldin M.I. , Abdun Mohammed Awadh , Al Mahamid Mohamad , Guo Huahu , Zheng Fengyu , Nobah Ali Mansour Ali MI 
Published: October 2023

AbstractThe occurrence of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy (LPD) is a significant concern, yet there is currently a lack of consensus on reliable
predictive methods for this complication. Therefore, the aim of this study was to assess the clinical significance of C-reactive protein (CRP) and procalcitonin (PCT) values and their
reliability in early predicting the development of clinically relevant pancreatic fistula (CRPF) following LPD.A retrospective analysis was conducted using data from 120 patients who had LPD between September 2019 and December 2021. Preoperative assessment data, standard patients’ demographic and
clinicopathological characteristics, intra- and postoperative evaluation, as well as postoperative laboratory values on postoperative days (PODs) 1, 3, and 7, including white blood cells
(WBCs), CRP, and PCT, were prospectively recorded on a dedicated database. Two clinicians separately collected and cross-checked all of the data.Among 120 patients [77 men (64%), 43 women (36%], CRPF occurred in 15 patients (11 grade B and 4 grade C fistulas). The incidence rate of CRPF was 12.3%. A comparison of the median values
of WBCs, PCT, and CRP across the two groups revealed that the CRPF group had higher values on most PODs than the non-CRPF group. Receiver operating characteristic (ROC) analysis was used to
calculate the area under the curve (AUC) and cutoff values. It was discovered that POD 3 has the most accurate and significant values for WBCs, CRP, and PCT. According to the ROC plots, the
AUC for WBCs was 0.842, whereas the AUC for PCT was 0.909. As for CRP, the AUC was 0.941 (95% CI 0.899–0.983, p < 0.01) with a cutoff value of 203.45, indicating a sensitivity of 93.3% and
specificity of 91.4%.Both CRP and PCT can be used to predict the early onset of CRPF following LPD, with CRP being slightly superior on POD 3.
Ossäre Bedeutung von Mineral- und Heilwässern:
Physiologie und epidemiologische Evidenz
Authors: Ströhle Alexander , Hahn Andreas 
Published: October 2023

ZusammenfassungMineral- und Heilwässer zeichnen sich durch eine sortenspezifische
Zusammensetzung aus, so dass sich die Wässer auch
ausernährungsphysiologischer Sicht voneinander unterscheiden. Viele
Mineral- und Heilwässer bilden eine quantitativ bedeutsame Quelle
für gut bioverfügbares Calcium und Magnesium. Calciumreiche
Wässer stellen somit eine günstige Alternative zum gut
löslichen Calciumcitrat dar, wie es in der Leitlinie der Bone Health
& Osteoporosis Foundation bei Achlorhydrie oder eingeschränkter
Magensäureproduktion (z. B. Therapie mit
Protonenpumpeninhibitoren) als Calciumquelle empfohlen wird.
Calciumwässer senken den Serumspiegel an Parathormon ähnlich
stark wie Calcium aus Milch oder Supplementen mit einem äquivalenten
Gehalt des Mineralstoffs. Damit verbunden ist bei alkalischen
Calciumwässern eine Hemmung der Knochenresorption. Auch senken
bikarbonatreiche Wässer die renale Säurelast sowie die
Calciumverluste über den Urin. Ungeklärt ist der Einfluss der
Wässer auf die Calciumbilanz und das Frakturrisiko. Der Natrium- und
Kaliumgehalt der meisten Wässer ist zu gering, um den
Knochenstoffwechsel nennenswert beeinflussen zu können. Auch
üben Wässer mit moderatem Fluoridgehalt
(0,70-1,0 mg/l) keinen, von anderen Nahrungsfaktoren (Calcium,
Protein) unabhängigen Einfluss auf die Mikrostruktur der Knochen
aus.
Aktuelle Therapieansätze der endokrinen Orbitopathie – sind die zielgerichteten Therapien die Zukunft?
Authors: Eckstein Anja , Stöhr Mareile , Görtz Gina-Eva , Gulbins Anne , Möller Lars , Fuehrer-Sakel Dagmar , Oeverhaus Michael 
Published: October 2023

ZusammenfassungDie endokrine Orbitopathie (EO) ist eine Autoimmunerkrankung der Augenhöhle, die am allerhäufigsten im Zusammenhang mit einer Schilddrüsenautoimmunerkrankung vom Typ Basedow auftritt. Für
die Diagnose spezifisch und für die Pathogenese von zentraler Bedeutung ist das Auftreten von gegen den TSH-Rezeptor gerichteten Autoantikörpern (TRAK). Diese Autoantikörper, zumeist mit
stimulierender Wirkung, induzieren eine unkontrollierte Schilddrüsenüberfunktion und in der Augenhöhle einen Gewebeumbau und eine mehr oder weniger ausgeprägte Entzündung. In Folge kommt es
zu einer periokulären, entzündlichen Schwellung in variablem Ausmaß, Exophthalmus und Fibrose der Augenmuskeln und dadurch zu einer Störung der symmetrischen Augenbeweglichkeit mit
Doppelbildwahrnehmung. In den letzten Jahrzehnten umfassten die therapeutischen Anstrengungen für die entzündliche Orbitopathie allgemein immunsuppressive Maßnahmen und für die
Schilddrüsenüberfunktion die symptomatische Therapie durch Hemmung der Schilddrüsenhormonproduktion. Mit dem Bekanntwerden, dass durch die TRAK auch ein wichtiger Wachstumsfaktorrezeptor
aktiviert wird, der IGF1R (Insulin-like-Growth-Factor-1-Rezeptor), wurden Biologika entwickelt, die diesen blockieren. Teprotumumab ist bereits in den USA zugelassen, und die Therapieeffekte
sind v. a. hinsichtlich der Exophthalmusreduktion enorm. Nebenwirkungen, v. a. Hyperglykämie und Hörstörungen, sind zu beachten. Inwieweit die Autoimmunreaktionen (Produktion der
TRAK/Anlocken von immunkompetenten Zellen) durch diese Therapien auch beeinflusst werden, ist noch nicht ausreichend geklärt. Rezidive nach der Therapie zeigen, dass die Hemmung der
Autoimmunreaktion im Therapiekonzept insbesondere bei schwerem Verlauf mit enthalten sein muss.
Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives
Authors: Sagar Ram , Shankar Uma , Khanna Ashish , Singh Kavita , Tiwari Ghanshyam 
Published: October 2023

AbstractLawsone, also known as 2-hydroxy-1,4-naphthoquinone, has been extensively studied and found to be a crucial precursor in the production of a diverse range of natural products such as molecular scaffolds, which are highly sought-after for biological research purposes. Due to its unique chemical composition, lawsone has been utilized for over a century as a starting material for the synthesis of numerous biologically active molecules and materials, and its intriguing properties have been showcased across a wide range of scientific and technological applications. Additionally, the various characteristics of lawsone have been widely used in organic synthesis processes. Recent advances in the synthesis of different scaffolds starting from lawsone, and their applications, are discussed in detail in the current review covering the period 2017 to 2023.1	Introduction2	Synthetic Developments on 2-hydroxy-1,4-naphthoquinone3	Conclusions
Does the Number of Stimuli Influence the Formation of the Endogenous Components of the Event-Related Auditory Evoked Potentials?
Authors: Oliveira Yorran Marques de , Calderaro Victor Goiris , Massuda Eduardo Tanaka , Zanchetta Sthella , Simões Humberto de Oliveira 
Published: October 2023

Abstract
Introduction The number of stimuli is important to determine the quality of auditory evoked potential records. However, there is no consensus on that number in studies, especially in the sample studied.
Objectives To investigate the influence of the number of rare stimuli on forming N2 and P3 components, with different types of acoustic stimuli.
Methods Cross-sectional, descriptive, comparative study, approved by the ethics committee of the institution. The sample comprised 20 normal hearing adults of both sexes, aged 18 to 29 years old, with normal scores in the mental state examination and auditory processing skills. The event-related auditory evoked potentials were performed with nonverbal (1 kHz versus 2 kHz) and verbal stimuli (/BA/ versus /DA/). The number of rare stimuli varied randomly in the recordings, with 10, 20, 30, 40, and 50 presentations.
Results P3 latency was significantly higher for nonverbal stimuli with 50 rare stimuli. N2 latency did not show any difference between the type and number of stimuli. The absolute P3 and N2-P3 amplitudes showed significant differences for both types of stimuli, with higher amplitude for 10 rare stimuli, in contrast with the other ones. The linear tendency test indicated significance only for the amplitude – as the number of rare stimuli increased, the amplitude tended to decrease.
Conclusion The components were identifiable in the different numbers of rare stimuli and types of stimuli. The P3 and N2-P3 latency and amplitude increased with fewer verbal and nonverbal stimuli. Recording protocols must consider the number of rare stimuli.
Liver Transplant Complications—A Pictorial Review
Authors: Ethiraju Vijayakumaran , Arunachalam Venkatesh Kasi , Vijayaragavan Paari , Poyyamoli Santhosh , Kumar Rajesh , Rajasekaran Sriman , Mahadevan Gowtham Sembagoundenvalasu , Cannane Seetharaman , Arunachalam Pudhiavan , Ramasamy Rajkumar , Kumar Harish , Selvaraj Swathigha , Kashyap Ravindar , Venkatesh Karthick , Mehta Pankaj , Cherian Mathew 
Published: October 2023

AbstractLiver transplantation is the most definitive treatment for decompensated chronic liver diseases, acute hepatic failure, and localized hepatocellular carcinomas. With the widespread use of extensive preop evaluation and advanced surgical techniques, the success rate of liver transplantation has dramatically risen over the decade. In a world of increasing demand for liver donors from brain dead donors, a rising trend is seen in the acceptance of living donor liver transplantation procedures. However, postoperative surveillance needs a lower threshold for early imaging to identify the most dreaded complications for salvaging the graft. This pictorial essay aims to categorize the postliver transplantation complications and various imaging findings to diagnose them. The complications can be broadly classified into vascular and nonvascular complications. The most important concern among vascular complications is hepatic artery thrombosis, which frequently results in graft failure. The nonvascular complication comprises biliary origin, infection, and immune response. Multimodality imaging is the need of the hour, which includes ultrasound as the primary tool for gross evaluation, followed by triphasic computed tomography and magnetic resonance imaging (MRI). Newer techniques in MRI, like diffusion-weighted imaging, arterial spin labeling, diffusion kurtosis imaging, blood oxygenation-level dependent, and magnetic resonance elastography, can also be used to diagnose these complications. Interventional management through minimal access has become the first line of management in certain vascular and nonvascular complications, which can salvage the graft.
Retrocardiac Opacities Detected on Chest Radiographs and their Imaging Workup: A Pictorial Review
Authors: Saikumar Divya , Ramachandran K. , Zunimol P.K.M. 
Published: October 2023

AbstractThe retrocardiac space is a tricky area in the chest radiograph, where abnormal densities are frequently missed out. Lesions in this area produce late pressure symptoms compared with those in the upper mediastinum. Early detection and proper evaluation of retrocardiac opacities can help the radiologist to establish the diagnosis before clinical signs and symptoms become apparent. We present a case series of 10 patients with incidentally detected retrocardiac opacities in the frontal chest radiograph, which were further evaluated with other imaging modalities such as lateral chest radiograph, computed tomography (CT) or magnetic resonance imaging (MRI) to establish the diagnosis. The final diagnosis included congenital conditions like esophageal duplication cyst and bronchogenic cyst; inflammatory conditions like spondylodiscitis, lung abscess, and lobar pneumonia; vascular conditions like aortic aneurysm; diaphragmatic pathologies like hiatus hernia; and rare tumors like cardiac papillary fibroelastoma, pulmonary neuroendocrine tumor, and ganglioneuroma. Cardinal signs that aid in the diagnosis of retrocardiac opacities are also discussed.
Myanmar Articulation, Resonation, Nasal Emission, and Nasal Turbulence Test: A Preliminary Study
Authors: Makarabhirom Kalyanee , Prathanee Benjamas , Rattanapitak Ampika 
Published: October 2023

Abstract
Background This article describes the development of the Myanmar Articulation, Resonation, Nasal Emission, and Nasal Turbulence test for children with cleft lip and palate (CLP), and evaluation of its validity and reliability.
Methods It was created by three Thai researchers and a Burmese research assistant based on Burmese phonology. The content validity was evaluated by six Burmese language experts. All test items were divided into three groups: high-pressure oral consonants, low-pressure oral consonants, and nasal consonants.
Results All items (58-word and 32-phrase/sentence) gave an excellent level of the expert agreement (item-level content validity indexes = 1.00). The target items were illustrated as color pictures. Each picture was clearly drawn and easy to identify. As a pilot study of face validity, all pictures were administered to 10 typical-developing children. The actual testing was assessed by 10 CLP children, and the developed test was analyzed through consultation of the Burmese teachers and interpreters from a speech camp. Testing scores for a total including three groups of target items were shown acceptable for internal consistency reliability (ranged from 0.4 to 0.88).
Conclusion The constructed test is valid in terms of its content.
Dynamic Reconstruction of Anal Sphincter with Camera Shutter Style Double-Opposing Gracilis Flaps
Authors: Wong Allen Wei-Jiat , Tan Grace Hui-Min , Koh Frederick Hong-Xiang , Chew Min Hoe 
Published: October 2023

AbstractFournier's gangrene is a life-threatening infection which requires prompt recognition, early surgical debridement of unhealthy tissue, and initiation of broad-spectrum antibiotics. Relook debridement are usually performed until all the devitalized tissue has been removed. Involvement of the anal sphincter may result in significant morbidity such as permanent incontinence. Dynamic reconstruction of the anal sphincter has always been one of the holy grails in the field of pelvic reconstruction.We demonstrate a new method of camera shutter style double-opposing gracilis muscle flaps that allows dynamic sphincteric function without the need for electrostimulation. The bilateral gracilis muscles are inset in a fashion that allows orthograde contraction of the muscle to narrow and collapse the neoanal opening. With biofeedback training, the patient is able to regain dynamic continence and return to function without a stoma. There was also no need for neurotization or microsurgery techniques to restore sphincteric function to the anus. The patient was able to reverse his stoma 14 months after the initial insult and reconstruction with biofeedback training without the use of electrostimulation.
Flexor Tendon Rupture Secondary to Gout
Authors: Lynn Jeremy V. , Strong Amy L. , Chung Kevin C. 
Published: October 2023

AbstractExtra-articular deposition of monosodium urate crystals is a widely recognized manifestation of gout. However, gouty infiltration of flexor tendons in the hand resulting in tendon rupture is exceedingly rare. This case report highlights a patient with gouty infiltration of flexor tendons in the right middle finger resulting in rupture of both the flexor digitorum profundus and flexor digitorum superficialis. Given the extent of gouty infiltration and need for pulley reconstruction, the patient was treated with two-stage flexor tendon reconstruction. Febuxostat was prescribed preoperatively to limit further deposition of monosodium urate crystals and continued postoperatively to maximize the potential for long-lasting results. Prednisone was prescribed between the first- and second-stage operations to prevent a gout flare while the silicone rod was in place. In summary, tendon rupture secondary to gouty infiltration is the most likely diagnosis in patients with a history of gout presenting with tendon insufficiency.
Electroclinical Features of Epilepsy in Kleefstra Syndrome
Authors: Giacomini Thea , Cordani Ramona , Bagnasco Irene , Vercellino Fabiana , Giordano Lucio , Milito Giuseppe , Ferrero Giovanni Battista , Mandrile Giorgia , Scala Marcello , Meli Mariaclaudia , Falsaperla Raffaele , Luria Gianvittorio , De Grandis Elisa , Canale Edoardo , Amadori Elisabetta , Striano Pasquale , Nobili Lino , Siri Laura 
Published: October 2023

Abstract
Background Kleefstra syndrome (KS) or 9q34.3 microdeletion syndrome (OMIM #610253) is a rare genetic condition featuring intellectual disability, hypotonia, and dysmorphic facial features. Autism spectrum disorder, severe language impairment, and sleep disorders have also been described. The syndrome can be either caused by a microdeletion in 9q34.3 or by pathogenic variants in the euchromatin histone methyltransferase 1 gene (EHMT1, *607001). Although epilepsy has been reported in 20 to 30% of subjects, a detailed description of epileptic features and underlying etiology is still lacking. The purpose of this study is to investigate epilepsy features in a cohort of epileptic patients with KS.
Methods This multicenter study investigated eight patients with KS and epilepsy. Our findings were compared with literature data.
Results We included five patients with 9q or 9q34.33 deletions, a subject with a complex translocation involving EHMT1, and two with pathogenic EHMT1 variants. All patients presented with moderate to severe developmental delay, language impairment, microcephaly, and infantile hypotonia. Although the epileptic manifestations were heterogeneous, most patients experienced focal seizures. The seizure frequency differs according to the age of epilepsy onset, with patients with early-onset epilepsy (before 36 months of age) presenting more frequent seizures. An overtime reduction in seizure frequency, as well as in antiseizure drug number, was observed in all patients. Developmental delay degree did not correlate with seizure onset and frequency or drug resistance.
Conclusion Epilepsy is a frequent finding in KS, but the underlying pathogenetic mechanism and specific features remain elusive.
2.5 Cobalt-Catalyzed Bidentate-Chelation-Assisted C—H Functionalization
Authors: Mandal R. , Garai B. , Sundararaju B. 
Published: October 2023

AbstractC—H bond functionalization catalyzed by high-valent-cobalt species with the aid of bidentate chelation has come a long way since the pioneering report by Daugulis almost a decade ago. Further study of the reaction mechanisms revealed that stoichiometric amounts of metal salts could be replaced with photocatalysts or electricity as one-electron oxidants, and approaches based on these strategies can be considered more environmentally friendly than the initially developed catalytic systems. Systematic investigations have led to a better understanding of the coordination environment of the in-situ-formed cobaltacycle, and this has led to the development of external chiral ligands for cobalt-catalyzed asymmetric C—H functionalizations. This review is a comprehensive summary of the documented methods for cobalt-catalyzed, bidentate-chelation-assisted C—H bond functionalizations as of early 2023.
2.13 Base-Metal-Catalyzed Hydrogenation of Polar Unsaturated Bonds
Authors: Li H. , Wang Y. , Liu Q. 
Published: October 2023

AbstractThe catalytic hydrogenation of carbonyl compounds to afford the corresponding saturated products is of great significance in both organic synthesis and industrial application. Historically, such transformations have generally been based on the use of noble-metal catalysts; however, in recent years, much attention has been paid to the development of earth-abundant-metal catalysts as alternatives to the well-established noble-metal congeners in terms of sustainability. This review comprehensively describes the hydrogenation of carbonyl compounds and related functional groups catalyzed by base metals, including iron, cobalt, manganese, nickel, and copper. These results are expected to promote the further development and prosperity of base-metal catalysis.
Unravelling cross-country regulatory intricacies of data governance: the relevance of legal insights for digitalization and international business
Authors: Coche Eugénie , Kolk Ans , Ocelík Václav 
Published: October 2023

AbstractIn an era of digital transformation, where data is often referred to as the ‘new oil’ of business, with data privacy and cybersecurity incidents recurrently making the headlines, international business (IB) scholars are increasingly grappling with the challenges posed by disparate data governance regulations. Recognizing the growing importance of this topic for IB research and policymaking, our paper seeks to offer a comprehensive examination of cross-country regulatory intricacies of data governance, frequently described by IB scholars as ‘complex’ and ‘pluralistic’ institutional contexts. This allows us to explore the various implications of diverse data governance regulations on international business, thus laying the groundwork for rigorous IB policy studies in this area. As a preliminary finding, we highlight a greater need for international cooperation, where both policymakers and multinational enterprises play a pivotal role. Using the EU data governance framework as an illustrative example, we structure our discussion around four policy areas of data governance: data use; data transfers; data storage; and data flows. We aim for this categorization to serve as a foundational basis for future IB research, aiding in tackling one of the most pressing digital challenges of this day and age: reconciling data privacy and security with data-driven innovation.
Adaptive anadromic regularization method for the Cauchy problem of the Helmholtz equation
Authors: Omri Haithem , Jday Fadhel 
Published: October 2023

Abstract
In this research work, we investigate the Cauchy problem for the Helmholtz equation. Considering the completion data problem in a bounded cylindrical domain with Neumann and Dirichlet conditions on a part of the boundary. An immediate approximation of missing boundary data is obtained using a method that factorizes the boundary value problem. This factorization uses the Neumann to Dirichlet or Dirichlet to Neumann operators that satisfy the Riccati equation. Some singularities appear in the solution of the Riccati equation for a particular length of the waveguide of the Helmholtz equation. We elaborate a new numerical method called ‘adaptive anadromic regularization method’ that can solve these operators beyond the singularity. In addition, we introduce a scaling matrix technique to the linear matrix equations associated with the Riccati equations to generate normalized solutions. Our numerical procedure not only approximates missing boundary data, but also provides an error estimate that allows efficient time stepping. Numerical tests proved to confirm the theory even in the presence of high noise levels.