bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and development of a soluble PDA-Emodin-PVP-MN patch and its anti-obesity effect in rats
Authors: Wang Haijiao , Wang Lifang , Wang Meng , Niu Jingjing , Yang Bowen , Wang Yinxiong , An Min , Sun Xiuxia , Yang Zhigang , Li Xuefeng , Shi Yanbin 
Published: February 2024

Abstract
Emodin has been proven to have weight-reducing and lipid-lowering effects. In order to make emodin play a better anti-obesity role, we designed and developed an emodin loaded dissolving microneedle patch, in which emodin existed in the form of emodin-polyvinylpyrrolidone co-precipitate (Emodin-PVP). Meanwhile, polydopamine (PDA) was added to the microneedle patch (PDA-Emodin-PVP-MN) for photothermal-enhanced chemotherapy of obesity. The drug loading of PDA-Emodin-PVP-MN was 0.37 ± 0.025 mg per patch, and the cumulative release of the microneedle patch was up to 96.25% under NIR irradiation (808 nm, 0.6 W/cm2). The microneedle patch with NIR radiation significantly reduced body weight, waist circumference, lipid-body ratio and serum free fatty acids of the obese model rats, and the volume of adipocytes of fat droplets was significantly reduced after the treatment with microneedle patch under NIR radiation. No obvious toxicity was observed in hemolytic test and microscopic histopathological analysis. The mechanism of action of the weight-reducing might be ascribed to the expression level of hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) involved in fat metabolism.
Improved marine predators algorithm for engineering design optimization problems
Authors: chun Ye , hua Xu , Qi Chen , yao Ye xin 
Published: February 2024

Abstract
The Marine Predators Algorithm (MPA) is recognized as one of the optimization method in population-based algorithm that mimics the foraging optimization strategy dominated by the optimal foraging theory, which encounter rate policy between predator and prey in marine ecosystems for solving optimization problems. However, MPA presents weak point towards premature convergence, stuck into local optima, lack of diversity, specifically, which is in the real-world niche problems within different industrial engineering design domains. To get rid of such limitations, this paper presents an Improved Marine Predators Algorithm (IMPA) to mitigate above mentioned limitations by deploying the self-adaptive weight and dynamic social learning mechanism that performs well and challenges tough multimodal benchmark-functions and CEC 2021 benchmark suite, compared with the state-of-the-art hybrid optimization algorithms and the recently modified MPA. The experimental results show that the IMPA outperforms with better precision attainment and better robustness due to its enjoying equalized exploration and exploitation feature over other methods. In order to provide a promising solution for industrial engineering design problems and highlight the potential of the IMPA as a useful tool for solving real-world problems. This study has implemented four highly representative engineering design problems, including Welded Beam Design, Tension/Compression Spring Design, Pressure Vessel Design and Three Bar Design. The experimental results also proved its efficiency to successfully solve the complex industrial engineering design problems.
Comparison of clinicopathologic characteristics and survival outcomes of various subtypes of breast cancer
Authors: Zangouri Vahid , Balaneji Souzan Soufizadeh , Deylami Iman , Zeinalpor Adel , Mousavi Seyed Amin , Amestejani Morteza 
Published: February 2024

Abstract
Background
Breast cancer is often classified into subtypes using immunohistochemical markers. This study aimed to compare the histopathological features, prognostic indicators, and clinical outcomes of diverse breast cancer subtypes.
Patients and methods:
A retrospective study was undertaken and all patients of various subtype of breast cancer over a 5 year period were included. Clinicopathological characteristics, including tumor size, lymph node (LN) metastasis, histological grade, immunohistochemical markers (estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2neu status), TNM staging, lymphovascular invasion (LVI), perineural invasion (PNI), and overall survival (OS),and Disease free survival(DFS) were comprehensively evaluated.
Results
Of the 9310 individuals diagnosed with breast cancer, a vast majority (99.4%) was females. Patients with invasive papillary carcinoma tumor subtypes presented with an older mean age (57.24 ± 12.92) years. Tumor grade exhibited a statistically significant correlation with tumor subtype (P < 0.001). Invasive lobular carcinoma (94.8%), IPC (94.3%), and mucinous carcinoma (93.6%) demonstrated excellent OS rates in stages I, II, and III. However, ICMP (94.6%) exhibited superior OS in stages II and III. In terms of DFS, IPC (94.2%), mucinous carcinoma (94.5%), and ICMP (93.6%) showed favorable DFS rates in TNM stages 1 and 2, with ICMP maintaining exceptional DFS rates in stage 3.
Conclusion
Invasive carcinoma with medullary features has the highest DFS rate across all stages, while mucinous and invasive papillary carcinoma have the highest DFS rates in TNM stage 1. Mucinous tumors have the highest DFS rates in TNM stage 2, followed by invasive carcinoma with medullary features. Invasive lobular carcinoma, invasive papillary carcinoma, and mucinous tumors had excellent overall survival (OS) rates in stages I, II, and III. Invasive carcinoma with medullary features had superior OS in stages II and III.
A Machine Learning Tool for Early Identification of Celiac Disease Autoimmunity
Authors: Dreyfuss Michael , Getz Benjamin , Lebwohl Benjamin , Ramni Or , Underberger Daniel , Ber Tahel Ilan , Steinberg-Koch Shlomit , Jenudi Yonathan , Gazit Sivan , Patalon Tal , Chodick Gabriel , Shoenfeld Yehuda , Ben-Tov Amir 
Published: February 2024

Abstract

Identifying which patients should undergo serologic screening for celiac disease (CD) may help diagnose patients who otherwise often experience diagnostic delays or remain undiagnosed. Using anonymized outpatient data from the electronic medical records of Maccabi Healthcare Services, we developed and evaluated a gradient boosted trees model to classify patients as at-risk for CD autoimmunity prior to first documented diagnosis or positive serum tissue transglutaminase (tTG-IgA). A train set of highly seropositive (tTG-IgA > 10X ULN) cases (n = 677) with likely CD and controls (n = 176,293) with no evidence of CD autoimmunity was used for model development. Input features included demographic information and commonly available laboratory results. The model was then evaluated for discriminative ability as measured by AUC on a distinct set of highly seropositive cases (n = 153) and controls (n = 41,087). Performance was estimated at one (AUC = 0.84), two (AUC = 0.81), three (AUC = 0.82) and four (AUC = 0.79) years prior to first documented evidence of disease. The model’s ability to distinguish cases of incident CD autoimmunity from controls shows promise as a potential clinical tool to identify patients at increased risk for having undiagnosed celiac disease in the community for serologic screening.
Rapid Diagnosis of Celiac Disease Based on Plasma Raman Spectroscopy Combined with Deep Learning
Authors: Shi Tian , Li Jiahe , Li Na , Chen Cheng , Chen Chen , Chang Chenjie , Xue Shenglong , Liu Weidong , Reyim Ainur Maimaiti , Gao Feng , Lv Xiaoyi 
Published: February 2024

Abstract
Celiac Disease (CD) is a primary malabsorption syndrome resulting from the interplay of genetic, immune, and dietary factors. CD negatively impacts daily activities and may lead to conditions such as osteoporosis, malignancies in the small intestine, ulcerative jejunitis, and enteritis, ultimately causing severe malnutrition. Therefore, an effective and rapid differentiation between healthy individuals and those with celiac disease is crucial for early diagnosis and treatment. This study utilizes Raman spectroscopy combined with deep learning models to achieve a non-invasive, rapid, and accurate diagnostic method for celiac disease and healthy controls.A total of 59 plasma samples, comprising 29 celiac disease cases and 30 healthy controls, were collected for experimental purposes. Convolutional Neural Network (CNN), Multi-Scale Convolutional Neural Network (MCNN), Residual Network (ResNet), and Deep Residual Shrinkage Network (DRSN) classification models were employed. The accuracy rates for these models were found to be 86.67%, 90.76%, 86.67% and 95.00%, respectively. Comparative validation results revealed that the DRSN model exhibited the best performance, with an AUC value and accuracy of 97.60% and 95%, respectively. This confirms the superiority of Raman spectroscopy combined with deep learning in the diagnosis of celiac disease.
Effects of high-intensity interval training on cardiometabolic biomarkers in prostate cancer patients undergoing active surveillance: A randomized controlled trial
Authors: Courneya K.S , Kang Dong-Woo , Field Catherine , Patel Dhruvesh , Fairey Adrian , Boule Normand , Dieli-Conwright Christina 
Published: February 2024

Abstract

Purpose: To report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in prostate cancer (PCa) patients on active surveillance (AS) from the Exercise During Active Surveillance for Prostate Cancer (ERASE) Trial.
Methods: Fifty-two men with PCa on AS were randomized to either an exercise (HIIT; n=26) or usual care (UC; n=26) group. The HIIT intervention consisted of progressive, supervised, aerobic HIIT at an intensity of 85 to 95% VO2peak for 28 to 40 minutes per session performed three times/week for 12 weeks. Blood samples were collected at baseline and post-intervention to analyze cardiometabolic biomarkers. Analysis of covariance was used to examine between-group mean differences.
Results: Blood data were obtained from 49/52 (94%) participants at postintervention. Participants were aged 63.4±7.1 years and 40% were obese. The HIIT group attended 96% of the planned exercise sessions. No significant between-group changes in weight were observed after the intervention. Compared to UC, HIIT significantly improved total cholesterol (-0.40 mmol/L; 95% confidence interval[CI], -0.70 to -0.10; p=0.011), non-high-density lipoprotein-c (-0.35 mmol/L; 95% CI, -0.60 to -0.11; p=0.006), insulin (-13.6 pmol/L; 95% CI, -25.3 to -1.8; p=0.025), insulin-like growth factor (IGF)-1 (-15.0 ng/mL; 95% CI, -29.9 to -0.1; p=0.048), and IGF binding protein (IGFBP)-3 (152.3 ng/mL; 95% CI, 12.6 to 292.1; p=0.033). No significant differences were observed for fasting glucose, HbA1c, other lipid markers, IGFBP-1, adiponectin, and leptin.
Conclusions: The ERASE Trial showed that a 12-week aerobic HIIT program improved several cardiometabolic biomarkers in PCa patients on AS that may contribute to cardiovascular health benefits and potentially influence the signaling pathways in the progression of prostate cancer. Further research is needed to explore the effects of exercise on cardiometabolic markers in men with PCa on AS and determine if these effects are associated with improved long-term clinical outcomes.
The Impact of Moderate to High-Intensity Physical Exercise on the Perception of Negative Emotional Intensity in College Students with High Psychological Stress
Authors: Tao Baole , Lu Tianci , Jiang Yueyan , Chen Hanwen , Chen Hao , Yan Jun 
Published: February 2024

Abstract
Method
Employing the "Chinese College Students' Psychological Stress Scale," 47 high-stress students were divided into a 25-member experimental group and a 22-member control group. The experimental group engaged in 40-minute group rope-jumping exercises thrice weekly for 12 weeks, following ACSM guidelines. A dual-choice Oddball task assessed the exercise intervention's impact on negative emotions. Results: (1) Post-intervention, the experimental group exhibited no significant change in reaction time to negative stimuli (p > 0.05); (2) The group experienced a notable reduction in negative reaction cost post-intervention (p < 0.05); (3) Significant variances were observed in P2, N2, and P3 waveform average amplitude and latency in main condition effects (p < 0.05); (4) Under negative conditions, the control group had shorter N2 latency (p < 0.05), higher P3 amplitude (p < 0.05), and shorter P3 latency (p < 0.05) than the experimental group. Conclusion: Physical exercise intervention enhances conflict inhibition abilities in individuals with high psychological stress. However, the neurophysiological responses to varying emotional stimulus intensities are more pronounced in these students.
Acoustic imaging of stable double diffusion in the Madeira abyssal plain
Authors: Duarte Ana , Peliz Alvaro , Matias Luis , Mendes Renato , Azevedo Leonardo 
Published: February 2024

Abstract
Sub-mesoscale and mesoscale (i.e., 1-10km and 10-200km, respectively) ocean processes are highly relevant for the understanding of global circulation, mixing of water masses and energy exchange between ocean layers. However, the processes happening at these scales are hard to be characterized using direct measurements of temperature and salinity. Direct measurements are obtained from vertical probes and/or autonomous vehicles, which, despite their high vertical resolution, are sparsely located in space and therefore unable to capture spatial details at these scales. Seismic oceanography (SO) data have been successful used to imaging and characterize the ocean at these spatial scales. These data represent indirect measurements of the ocean temperature and salinity along kilometric transects with high horizontal resolution (i.e., a near-synaptic view of the system under investigation), but lower vertical resolution when compared with direct observations. Despite its complex oceanographic setting, the Madeira Abyssal Plain is still largely uncharacterized due to the lack of direct observations. We show for the first time a comprehensive processing, modelling and interpretation of three 2-D seismic oceanography sections from this region. The data show coherent seismic reflection in space, depth and time and shed light into this oceanographic setting with an unprecedent horizontal resolution. The SO modelling and interpretation are combined with existing direct measurements and a quantitative method to correlate thermohaline staircases interpreted from conductivity-temperature-depth casts and seismic reflections is proposed. The results show the relatively stable presence of thermohaline staircases in simultaneously time and space between 1200–2000 m of water depth and their spatial variability and contribute to the generalization of SO in physical oceanography.
Diagnosis of bilateral ovarian dysgerminoma in an anemic new mother: a case report
Authors: Giordano Filippo Casaccia , Grossi Elena , Carignani Beatrice De Luca , Buggio Laura , Croci Giorgio Alberto , Scarfone Giovanna 
Published: February 2024

Abstract
Background
Ovarian dysgerminomas are rare, malignant germ cell tumors primarily affecting young women. Conservative surgery sometimes followed by chemotherapy is the treatment of choice, particularly in young patients with a strong desire to have pregnancies. Ovarian germ cell tumors during pregnancy are exceedingly rare. In these cases, the role of tumor markers is limited, as well as in pregnancy after cancer, or in cancers diagnosed immediately after pregnancy.
Moreover, post-partum anemia is a very common occurrence with a wide differential diagnosis, comprising hemorrhage and hemodilution due to pregnancy, but it only exceptionally includes paraneoplastic anemia.
Case presentation
We present the case of a 20 years-old woman from Bangladesh with severe unexplained post-partum anemia and her difficult diagnostic and therapeutic course, influenced by the young age of the patient, the fact that she had just given birth, the need for a conservative approach and lastly the difficult challenge set by the complete language barrier.
Conclusions
This peculiar case may help decision-making either from a diagnostic or a therapeutic point of view, both in a gynecologic oncological setting and in an obstetric one.
Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood
Authors: Midya Vishal , Nagdeo Kiran , Lane Jamil , Torres-Olascoaga Libni , Martínez Gabriela , Horton Megan , Gennings Chris , Téllez-Rojo Martha , Wright Robert , Arora Manish , Eggers Shoshannah 
Published: February 2024

Abstract
Emerging research suggests that exposures to metals during pregnancy and gut microbiome (GM) disruptions are associated with depressive disorders in childhood. Akkermansia muciniphila, a GM bacteria, has been studied for its potential antidepressant effects. However, its role in the influence of prenatal metal exposures on depressive symptoms during childhood is unknown. Leveraging a well-characterized pediatric longitudinal birth cohort and its microbiome substudy (n=112) and using a state-of-the-art machine-learning model, we investigated whether the presence of A.muciniphila in GM of 9-11-year-olds modifies the associations between exposure to a specific group of metals (or metal-clique) during pregnancy and concurrent childhood depressive symptoms. Among children with no A.muciniphila, a metal-clique of Zinc-Chromium-Cobalt was strongly associated with increased depression score (P<0.0001), whereas, for children with A.muciniphila, this same metal-clique was weakly associated with decreased depression score(P<0.4). Our analysis provides the first exploratory evidence hypothesizing A.muciniphila as a probiotic intervention attenuating the effect of prenatal metal-exposures-associated depressive disorders in late childhood.
The cultural efficacy of elementary school students：scale development and validation
Authors: Wang Shuzhen , Tian Mei , Yuan Xiqing , Wang Xiao , Xing Qiulian , Ming Yu , Cheng Xinyu , Kang Yanjun , Yang Shuhui , Wang Peng 
Published: February 2024

Abstract
Culture plays an important role in human social life,and cultural factors are also an important basis for the modernization of national governance.A strong culture makes a strong nation. This study aimed to develop a cultural efficacy scale for elementary school students in China and test its psychometric properties. The scale was conducted among 911 elementary school students (Mage = 10.64, SDage = 1.82, Nboy = 488). The data were then randomly divided into two groups. Group 1 (n = 457) were used for item and exploratory factor analyses, and Group 2 (n = 454) were used for confirmatory factor analysis and for providing criteria evidence. Fourteen items were retained in the scale, and the cumulative method interpretation rate was 48.75%. Statistically significant differences existed between the high and low groups in the independent samples t test. The structural model was well fitted (RMSEA = 0.056, SRMR = 0.044, TLI = 0.920, CFI = 0.934), and the range of factor load was 0.308–0.676. The Cronbach’s alpha was 0.83, and criteria evidence was moderately significant. The outcomes show that the developed scale has good reliability and validity and can be used to assess the cultural efficacy level of elementary school students.
Isosurface geometric measurement on volume-rendered images: A novel method for quantitative measurements of complex cardiac anatomical features
Authors: Kamiya Kenichi , Nagatani Yukihiro , Matsubayashi Jun , Uemura Ryo , Oki Tatsuya , Matsubayashi Yuji , Terada Shinya , Vigers Piers , Nakata Susumu , Watanabe Yoshiyuki , Suzuki Tomoaki 
Published: February 2024

Abstract

Measuring living heart anatomy using three-dimensional (3D) images remains challenging. To address this, a method called isosurface measurement on volume-rendered images (IMVR) has been developed. This study aims to validate IMVR in quantitative measurement by comparing it with curved planar reformation (CPR). Five 3D-printed human cardiac models created from computed tomography (CT) images were optically scanned, and selected features were measured for reference. The models were CT-scanned, and the datasets were processed for IMVR and CPR measurements. Overall, 157 anatomical features (105 in the aortic root, 52 in the coronary artery) were measured three times by two observers for each method, and the agreement with the reference values was assessed using the Bland–Altman analysis. In the aortic root measurement, the lower and upper 95% limits of agreement (LOAs, mm) for IMVR were (− 3.1, 2.4) and (− 1.3, 0.9), whereas those for CPR were (− 5.9, 5.2) and (− 5.9, 6.3). In the coronary artery measurement, the LOAs for IMVR were (− 2.6, 2.2) and (− 1.2, 0.8), while those for CPR were (− 9.2, 8.6) and (− 9.5, 8.5). For both methods, the intra-class coefficient indicated high intra- and inter-observer reliability. Thus, IMVR demonstrated greater accuracy than CPR and facilitated 3D measurements of complex cardiovascular features.
Waiting for Self-Healing as a Primary Management Strategy for Lower Lip Mucoceles
Authors: LIU Jian-lin , LIU Yu-nan , WANG Lin , WANG Dian-can 
Published: February 2024

Abstract

Objectives
Oral mucoceles are most frequently encountered on the lower lip. A variety of treatment options are currently employed, including surgical excision, pharmacological injections, and laser therapy. However, each of these approaches may introduce risks and potential complications. Clinical practice has demonstrated a potential for self-healing in lower lip mucoceles, making a conservative observational approach more appealing. This research is a prospective study aimed at evaluating the self-healing capacity of lower lip mucoceles.
Methods
In this prospective study, patients with mucoceles were encouraged to intentionally delay medical intervention and to wait for self-healing. Disappearance of the mucocele for at least 3 months was defined as self-healing.
Results
Thirty patients with lower lip mucoceles were included. With no intervention, 24 patients (80%) reported self-healing of lower lip mucoceles. The mean natural duration of the mucoceles was 3.63 (± 4.7; 1–24) months. After self-healing of the mucocele, the patients were followed up for 17.21 (± 9.45; 2–30) months and there were no reported recurrences.
Conclusions
Lower lip mucoceles have a high potential for self-healing and patients may be routinely encouraged to wait for self-healing.
Clinical Relevance
The high self-healing rate observed in this study suggests that a conservative, non-interventional approach might be considered as the first-line management for lower lip mucoceles.