bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported compliance of patients receiving antihypertensive treatment: Use of a telemonitoring home care system
Authors: Port Kristjan , Palm Kairit , Viigimaa Margus 
Published: August 2003

summary Home monitoring of blood pressure and self-reported drug administration were investigated. Fifty hypertensive patients used a home telemonitoring service for a year. An average of 39% reported that they had followed their prescribed drug intake. Long-term treatment effectiveness was measured as the change in the weekly average morning systolic blood pressure (SBP). Sixteen patients showed a decrease in SBP, 21 no change and 13 a rise in SBP. There was a significant relationship between reported drug intake and variation in daily blood pressure. Groups differed in the magnitude of this effect. Compared with other groups, the difference (3.4 mmHg) between morning and evening SBP was greatest (and significant) in the patients whose blood pressure decreased during the study. Self-reported data using remote home monitoring reveals considerable differences in patterns of compliance with prescribed treatment as well as in the effectiveness of the drug regime.
The effect of telemedicine on consultation time
Authors: Baldwin Lynne , Clarke Malcolm , Hands Linda , Knott Mary , Jones Russell 
Published: August 2003

summary We have implemented an ‘evidence-based referral’ for primary care patients in dermatology, cardiology and peripheral vascular disease. Telemedicine clinics bring together a district nurse, patient and vascular surgeon to discuss diagnosis, management and care. During a 30-month study, a total of 30 patients participated in telemedicine clinics. The mean consultation time fell from 23 to 10 min. In parallel, the type of consultation changed from dermatology to vascular surgery. Nineteen patients participated in vascular telemedicine clinics over the last 16 months of the study. The average consultation time was 10 min (SD 1), which included discussion of the case and negotiation of its management. The average consultation time in the equivalent outpatient clinic in the same hospital for the same consultant was 15 min. The acquisition of the relevant information in primary care could lead to a reduction of 75% in outpatient clinic appointments.
Crystallographic report: Thallium(18‐crown‐6) hexafluorophosphate, [Tl(18‐crown‐6)](PF6)
Authors: Liu Fenghui 
Published: August 2003

AbstractThallium(18‐crown‐6) hexafluorophosphate was prepared and its structure was determined by X‐ray diffraction analysis. The Tl+ ion is surrounded by six oxygen atoms of 18‐crown‐6 and three fluorine atoms of $\hbox{PF}_{6}^{-}$, forming a sandwiched structure. If the three Tl–F interactions were considered significant, the coordination number in the title compound would be nine. Copyright © 2003 John Wiley & Sons, Ltd.
Synthesis and characterization of a new modification of PtAl
Authors: Weidenthaler Claudia , Brijoux Werner , Ould‐Ely Teyeb , Spliethoff Bernd , Bönnemann Helmut 
Published: August 2003

AbstractA new PtAl phase, which is stable at room temperature under oxidizing conditions, has been synthesized at 200 °C and 5 MPa. X‐ray studies reveal it to be different from the known polymorphs of PtAl, which crystallize in the FeSi and CsCl structure types. The crystal structure of the new PtAl modification is found to be isotypical with the low‐temperature modification of PdAl.In situhigh‐temperature X‐ray diffraction experiments in air were performed to study the thermal behavior of the new PtAl alloy. In the temperature range between 400 and 700 °C, Pt5Al3forms as an intermediate phase. At higher temperature the alloy decomposes, resulting in the formation of platinum and Al2O3. The thermodynamic instability at high temperatures explains why this new modification has not been observed using contemporary metallurgic processes. Copyright © 2003 John Wiley & Sons, Ltd.
Crystallographic report: A three‐dimensional coordination polymer: [Zn6(btc)4(4,4′‐bipy)5]n (btc = 1,2,4‐benzenetricarboxylate; 4,4′‐bipy = 4,4′‐bipyridine)
Authors: Zheng Pei‐Qing , Long La‐Sheng , Huang Rong‐Bin , Zheng Lan‐Sun 
Published: August 2003

AbstractThe three‐dimensional (3D) coordination polymer [Zn6(btc)4(4,4′‐bipy)5]n (1) (btc = 1,2,4‐benzenetricarboxylate; 4,4′‐bipy = 4,4′‐bipyridine) has been prepared hydrothermally. The zinc(II) centers in 1 are bridged by btc ligands to form a trinuclear subunit, which is further linked by 4,4′‐bipy and btc ligands to construct the 3D coordination architecture. Copyright © 2003 John Wiley & Sons, Ltd.
Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H5FeC5H4CO2SbPh4 and (C5H5FeC5H4CO2)2Sb(4‐CH3C6H4)3
Authors: Liu Run‐Chang , Ma Yong‐Qiang , Yu Lin , Li Jin‐Shan , Cui Jing‐Rong , Wang Rui‐Qing 
Published: August 2003

AbstractA series of arylantimony ferrocenecarboxylates with the formula (C5H5FeC5H4CO2)nSbAr(5−n) (n = 1, 2; Ar = C6H5, 4‐CH3C6H4, 3‐CH3C6H4, 2‐CH3C6H4, 4‐ClC6H4, 4‐FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H4CO2)2Sb(4‐CH3C6H4)3 and C5H5FeC5H4CO2SbPh4 were determined by X‐ray diffraction. Four human neoplastic cell lines (HL‐60, Bel‐7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 µM show certain in vitro antitumor activities. Copyright © 2003 John Wiley & Sons, Ltd.
Mild depolymerization of silicone grease using aluminum(III)chloride: high‐yield synthesis and crystal structure of [{ClSiMe2OAlCl2}2], and its controlled hydrolysis on aluminum surfaces
Authors: Alexander Morgan R. , Mair Francis S. , Pritchard Robin G. , Warren John E. 
Published: August 2003

AbstractReaction of AlCl3 with {Me2SiO}n (Dow‐Corning high‐vacuum grease) at an Al : Si ratio of 1 : 1 in hexane at room temperature yielded a large crop of colorless crystals of [{ClSiMe2OAlCl2}2], which were characterized by single‐crystal X‐ray diffraction and NMR. These crystals hydrolyzed on an aluminum surface to give a coating of silicone oil interspersed with particles of [Al(OH2)6]Cl3, as determined by powder X‐ray diffraction and X‐ray photoelectron spectrometry. Copyright © 2003 John Wiley & Sons, Ltd.
Some ferrocenyl Schiff bases with nonlinear optical properties
Authors: Huang Guo‐Sheng , Liang Yong‐Min , Wu Xiao‐Li , Liu Wei‐Min , Ma Yong‐Xiang 
Published: August 2003

AbstractEleven new ferrocenyl Schiff bases containing a benzene ring and CN in a conjugating chain have been synthesized by facile methods and characterized by 1H NMR, elemental analysis and fast atom bombardment mass spectrometry. Cyclic voltammetry was used to determine their electrochemical properties and electron‐withdrawing effects. It is shown that these pull–push ferrocenyl compounds have nonlinear optical responses according to their electronic absorption spectra and powder second harmonic generation measurements. Copyright © 2003 John Wiley & Sons, Ltd.
Vinylarenetricarbonyl complexes of chromium as chain propagation regulators for polymerization of acrylic monomers
Authors: Grishin Dmitry F. , Semyonycheva Ludmila L. , Artemov Alexander N. , Telegina Ekaterina V. , Valetova Natalia B. , Illichev Ilya S. 
Published: August 2003

AbstractThe polymerization of methyl methacrylate and butyl acrylate initiated by azo‐bis‐isobutyronitrile in the presence of metal‐containing monomers (p‐methylstyrene‐, stilbene‐ and α‐methylstyrene‐chromiumtricarbonyl) was studied. Kinetic parameters (i.e. the decrease in the autoacceleration during the polymerization of acrylic monomers, its shift towards a high conversion region in the presence of α‐methylstyrenechromiumtricarbonyl, a linear dependence of the molecular weight of a polymethyl methacrylate and the shift of molecular‐weight distribution curves to a high molecular weight region with conversion) demonstrate the influence of vinylarenetricarbonyl complexes of chromium on basic steps of polymerization. It is important to note that the above organometallic compounds enable the controlled synthesis of polymers under temperature conditions (50–70 °C) corresponding to those of the industrial polymer production. Copyright © 2003 John Wiley & Sons, Ltd.
Synthesis and characterization of benzoxazine‐based phenolic resins: Crosslinking study
Authors: Espinosa M. A. , Cádiz V. , Galià M. 
Published: August 2003

AbstractModified novolac resins with benzoxazine rings were prepared. The synthetic method involved the preparation of 1,3,5‐triphenylhexahydro‐1,3,5‐triazine as an intermediate that further reacts with the novolac resin. The catalytic effects of phenols, carboxylic acids, and Lewis acids on the benzoxazine ring‐opening polymerization were shown. The curing behavior of the benzoxazine compounds and the thermal properties of the cured resin were studied, and the results indicated improved degradation behavior for flammability. V‐0 materials were obtained when the materials were tested for ignition resistance using the UL‐94 test. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 470–481, 2003
Study of the polymerization ability of a novel type of aniline monomer, 2‐(m‐aminophenylbenzothiazole)
Authors: Folch I. , Borrós S. 
Published: August 2003

AbstractThe oxidation process of the aniline derivative [2‐(m‐aminophenylbenzothiazole] was studied, and the products obtained from its oxidation and the coreaction with different ratios of aniline were characterized in structure and properties. IR, NMR, and MALDI‐TOF spectrometries demonstrate the actual polymerization of the monomer, whereas DSC, TGA, and conductivity measurements show their good thermal and electrical properties when combined with aniline. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 497–504, 2003
Preparation of a mono‐sheet bipolar membrane by simultaneous irradiation grafting polymerization of acrylic acid and chloromethylstyrene
Authors: Fu Rongqiang , Xu Tongwen , Yang Weihua , Pan Zhongxiao 
Published: August 2003

AbstractA new type of mono‐sheet bipolar membrane was produced from a porous polyethylene (PE) substrate using simultaneous irradiation grafting polymerization of acrylic acid (AA) on one side and chloromethylstyrene (CMS) on the other side. PE film with absorbent filter paper absorbing AA on one side and paper absorbing CMS on the other side was irradiated in the cobalt‐60 gamma ray irradiation field, followed by quaternization with trimethylamine aqueous solution. AA and CMS were grafted on the substrate membrane simultaneously. The performance of the final membrane is significantly affected by the irradiation time. For short irradiation time, the prepared membrane behaves as a bipolar membrane; whereas for long irradiation time, the final membrane behaves as a charge mosaic membrane. Therefore, by controlling the conditions, a bipolar membrane with good current rectification can be prepared, across which the voltage drop is ∼2.0 V at the current density 800 A/m2 in 1.0 M NaOH. This preparation method is simple and can be applied both in laboratory and in industry. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 572–576, 2003
Studies on the critical phase‐transition behavior of cholesteric N‐phthaloyl chitosan/dimethyl sulfoxide solutions by five techniques
Authors: Wu Yusong , Dong Yanming , Zhou Hua , Ruan Yonghong , Wang Huiwu , Zhao Yaqing 
Published: August 2003

AbstractA selectively side‐modified chitosan derivative, N‐phthaloyl chitosan (PhthCs), was prepared. Five techniques, including circular dichroism (CD) spectropolarimetry, ultraviolet–visible (UV–vis) spectroscopy, small‐angle light scattering (SALS), polarized optical microscopy (POM), and differential scanning calorimetry (DSC), were simultaneously applied to investigate the order–disorder phase transition for the lyotropic PhthCs/dimethyl sulfoxide system. POM observations suggested that the critical concentration was 48 wt %, which agreed well with the DSC measurements. A four‐leaf SALS picture was recorded in biphasic solutions. The four‐leaf type became a circular symmetric scattering picture with a further increase in the concentration. A sharp peak at 330 nm was recorded in dilute isotropic solutions with CD measurements. The sharp peak turned into a broad tailed peak from 330 to 800 nm after the phase transition occurred. The sharp peak was induced by a chromophore (phthoyl group). The broad peak was attributed to the formation of short‐range‐ordered organization in the concentrated solutions. In UV–vis studies, when the system varied from isotropic to anisotropic, the absorption band turned into platform. These five techniques were proven to be feasible methods for measuring the phase transition of cholesteric liquid crystals. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 583–586, 2003
Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: A sixteen‐year followup of meniscectomy with matched controls
Authors: Englund M. , Roos E. M. , Lohmander L. S. 
Published: August 2003

AbstractObjectiveTo investigate long‐term radiographic and patient‐relevant outcome of isolated limited meniscectomy with regard to type of meniscal tear and extent of surgical resection.MethodsWe studied 155 patients with intact cruciate ligaments (mean ± SD age 54 ± 12 years) who had undergone meniscectomy an average of 16 ± 1 years earlier. The patients were examined using standardized radiography and validated self‐administered questionnaires. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was used to quantify knee‐related symptoms, and the definition of a symptomatic knee was determined. We used 68 control subjects matched for age, sex, and body mass index to calculate the relative risks (RRs).ResultsRadiographic tibiofemoral osteoarthritis (OA) (Kellgren/Lawrence grade ≥2) was present in 66 index knees (43%), of which 39 (59%) were considered to be symptomatic according to the KOOS. In total, 77 patients (50%) had a symptomatic index knee. In a multivariate model, degenerative meniscal tears were associated with both radiographic OA (P = 0.030) and combined radiographic and symptomatic OA (P ≤ 0.015). The RRs for combined radiographic and symptomatic OA after degenerative and traumatic types of meniscal tear were 7.0 (95% confidence interval [95% CI] 2.1–23.5) and 2.7 (95% CI 0.9–7.7), respectively, compared with matched controls.ConclusionAn isolated meniscal tear treated by limited meniscectomy is associated with a high risk of radiographic and symptomatic tibiofemoral OA at 16‐year followup. Factors associated with worse outcome were degenerative meniscal lesions and extensive resections. We suggest that degenerative meniscal tears may be associated with incipient OA, and that the meniscal tear signals the first symptom of the disease.
Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease
Authors: Okada Satoshi , Weatherhead Elizabeth , Targoff Ira N. , Wesley Robert , Miller Frederick W. 
Published: August 2003

AbstractObjectiveTo determine if geoclimatic factors may influence the nature and frequency of dermatomyositis (DM), polymyositis, and associated autoantibodies around the world.MethodsWe assessed, in the first global evaluation of these conditions, the relationship between 13 geoclimatic variables that may modulate disease and the relative proportion of DM and its associated autoantibody anti–Mi‐2, directed against an SNF2‐superfamily helicase associated with the nucleosome remodeling and histone acetylation and deacetylation complex, in a global myositis population. Altogether, 919 consecutive patients from populations at 15 locations were studied.ResultsUnivariate and multivariate analyses demonstrated that of the variables evaluated, surface ultraviolet (UV) radiation intensity (irradiance) most strongly contributed to the relative proportion of DM and was strongly related to the proportion of anti–Mi‐2 autoantibodies (weighted r = 0.939, P < 4 × 10‐7 and weighted r = 0.69, P = 0.02, respectively). Published ethnogeographic immunogenetic allele frequencies imply that the striking differences in the proportion of DM‐ and DM‐specific autoantibodies observed around the world are not the result of inherent global variations in known genetic risk factors.ConclusionThese data suggest that UV radiation exposure may modulate the clinical and immunologic expression of an autoimmune disease in different populations around the world.
Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys
Authors: Xie Chun , Liang Zhiyan , Chang Sooghee , Mohan Chandra 
Published: August 2003

AbstractObjectiveThe autoantibody specificities that dominate the deposits in lupus kidneys remain unclear. Reasoning that previously utilized elution buffers such as acidic glycine and ammonium thiocyanate may not have been maximally effective in eluting all Ig deposits from the kidneys, this study was conducted to experiment with a stronger dissociating agent, urea‐glycine.MethodsSeven antinuclear antibody–positive, nephritic female (SWR × NZB)F1 (SNF1) lupus mice were selected for the elution study. Deposited Ig was eluted from their kidneys using 3 different elution buffers: 0.15M glycine‐HCl buffer, 1.3M ammonia thiocyanate/0.15M glycine‐HCl buffer, and 5M urea/0.15M glycine‐HCl buffer. All eluates were tested for specificity against a variety of nuclear and glomerular antigens.ResultsCompared with conventional elution buffers, the urea‐based regimen eluted severalfold more IgG and IgM antinuclear antibodies from the kidneys of nephritic SNF1 lupus mice. IgG anti–double‐stranded DNA (anti‐dsDNA) antibodies were not only the most prevalent species in these renal deposits, they were also heavily enriched in the kidneys, relative to the corresponding serum levels. A substantial fraction of the anti–single‐stranded DNA and antihistone/DNA (but not antihistone) reactivity in these eluates was due to cross‐reactive anti‐dsDNA antibodies. No reactivity with SSA, SSB, Sm, RNP, Jo‐1, Scl‐70, or ribosomal P antigens could be demonstrated in these eluates. Importantly, the urea‐glycine eluates differed from the conventional eluates in having significantly greater reactivity to glomerular substrate and laminin.ConclusionThis novel urea‐based elution provides further support for the dominance of antibodies in lupus kidneys, with strong polyreactivity to DNA and glomerular substrate.
Inflammation and angiogenesis in osteoarthritis
Authors: Haywood L. , McWilliams D. F. , Pearson C. I. , Gill S. E. , Ganesan A. , Wilson D. , Walsh D. A. 
Published: August 2003

AbstractObjectiveTo quantify the relationship between inflammation and angiogenesis in synovial tissue from patients with osteoarthritis (OA).MethodsHematoxylin and eosin staining and histologic grading for inflammation were performed for 104 patients who met the American College of Rheumatology criteria for OA and had undergone total joint replacement or arthroscopy. A purposive sample of synovial specimens obtained from 70 patients was used for further analysis. Vascular endothelium, endothelial cell (EC) proliferating nuclei, macrophages, and vascular endothelial growth factor (VEGF) were detected by immunohistochemical analysis. Angiogenesis (EC proliferation, EC fractional area), macrophage fractional area, and VEGF immunoreactivity were measured using computer‐assisted image analysis. Double immunofluorescence histochemical analysis was used to determine the cellular localization of VEGF. Radiographic scores for joint space narrowing and osteophyte formation in the knee were also assessed.ResultsSynovial tissue samples from 32 (31%) of 104 patients with OA showed severe inflammation; thickened intimal lining and associated lymphoid aggregates were often observed. The EC fractional area, EC proliferation, and VEGF immunoreactivity all increased with increasing histologic inflammation grade and increasing macrophage fractional area. In the synovial intimal lining, VEGF immunoreactivity was localized to macrophages and increased with increasing EC fractional area and angiogenesis. No inflammation or angiogenic indices were significantly correlated with radiographic scores.ConclusionInflammation and angiogenesis in the synovium are associated with OA. The angiogenic growth factor VEGF generated by the inflamed synovium may promote angiogenesis, thereby contributing to inflammation in OA.
Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT‐1 pathway between rheumatoid tissues
Authors: van der Pouw Kraan Tineke C. T. M. , van Gaalen Floris A. , Kasperkovitz Pia V. , Verbeet Nicolette L. , Smeets Tom J. M. , Kraan Maarten C. , Fero Mike , Tak Paul‐Peter , Huizinga Tom W. J. , Pieterman Elsbet , Breedveld Ferdinand C. , Alizadeh Ash A. , Verweij Cornelis L. 
Published: August 2003

AbstractObjectiveTo generate a molecular description of synovial tissue from rheumatoid arthritis (RA) patients that would allow us to unravel novel aspects of pathogenesis and to identify different forms of disease.MethodsWe applied complementary DNA microarray analysis to profile gene expression, with a focus on immune‐related genes, in affected joint tissues from RA patients and in tissues from osteoarthritis (OA) patients as a control. To validate microarray data, real‐time polymerase chain reaction was performed on genes of interest.ResultsThe gene expression signatures of synovial tissues from RA patients showed considerable variability, resulting in the identification of at least two molecularly distinct forms of RA tissues. One class of tissues revealed abundant expression of clusters of genes indicative of an involvement of the adaptive immune response. Detailed analysis of the expression profile provided evidence for a prominent role of an activated signal transducer and activator of transcription 1 pathway in these tissues. The expression profiles of another group of RA tissues revealed an increased tissue remodeling activity and a low inflammatory gene expression signature. The gene expression pattern in the latter tissues was reminiscent of that observed in the majority of OA tissues.ConclusionThe differences in the gene expression profiles provide a unique perspective for distinguishing different pathogenetic RA subsets based on molecular criteria. These data reflect important aspects of molecular variation that are relevant for understanding the biologic dysregulation underlying these subsets of RA. This approach may also help to define homogeneous groups for clinical studies and evaluation of targeted therapies.