bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indosinian anatexis of Paleoproterozoic granites in the east Cathaysia Block, South China
Authors: Zhang Wei , Zhou Hanwen , Zhou Xiaohua , Zhao Xilin , Liu Huan , Jiang Yang , Li Chunzhong 
Published: January 2024

AbstractGranulite facies metamorphism and crustal anatexis exist in the East Cathaysia Block, the exact timing of granulite facies partial melting and its link with orogenesis have not been well constrained. In this study, we carried out petrography, whole rock geochemistry, and zircon U–Pb dating, trace elements and Hf isotopes analyses on Dazhe gneissic granite and banded migmatite from the Badu Group in southwest Zhejiang province in the East Cathaysia Block. The melts were produced through the dehydration of biotite, such as biotite + quartz + plagioclase = orthopyroxene + K‐feldspar + melt and biotite + quartz + plagioclase + sillimanite = garnet + K‐feldspar + melt. Zircons from these rocks show clear core‐rim structure and yield rim and core concordant ages at 233 Ma and 1.83 Ga, respectively. The zircon rims suggesting the melts and the cores are suggesting the protolith of Dazhe gneissic granite and banded migmatite were crystallized from an evolving magma. The zircon cores and rims have negative εHf(t) = −2.2 ~ −6.3 and εHf(t) = −22.8 ~ −32.4, and they give suggestion of the presence of Neoarchean components. Although the major‐element compositions of the gneissic granite and banded migmatite are slightly different, the trace‐element spider diagram and REE pattern show they are similar, and then we find that the protoliths are A‐type granodiorite/diorite. Combined with the published data, we suggested that the Dazhe gneissic granite and banded migmatite were formed through granulite facies partial melting at 233 Ma, which was promoted by crustal shortening and thickening of the collision orogeny between East Cathaysia Block and an unknown terrane with a NNE trend structure line. The protoliths (granite or granodiorite) of Dazhe gneissic granite and banded migmatite crystallized at 1.83 Ga by reworking of the Neoarchean components of East Cathaysia Block. The Paleoproterozoic (1912–1819 Ma) collisional orogeny and the later intraplate rifting stage are corresponding to the aggregation and breakup of the Columbia supercontinent.
Baked sorghum tortilla chips: effects of baking conditions on physicochemical properties
Authors: Messina Valeria , Xu Binghan , Khoddami Ali , Roberts Thomas H. 
Published: January 2024

SummaryWholegrain sorghum (Sorghum bicolor) is nutritious and gluten‐free. Despite its health benefits, the potential for wholegrain sorghum to be incorporated into a large range of food products in Western countries is yet to be realised. In this study, we developed oven‐baked sorghum‐based tortilla chips to create a healthy sugar‐free product for the snack market. Tortilla chips were made separately with flour from white sorghum (cv. Liberty) and a red sorghum (cv. Taurus), each mixed with corn flour (85:15% w/w) to give a gluten‐free product, as well as a corn‐wheat control (85:15% w/w). Three parameters for the baking process were varied: dough sheet thickness (0.95 and 1.45 mm), baking temperature (160 and 180 °C) and baking time (2 and 4 min). Physicochemical properties of the tortilla chips were then determined: moisture content, water activity, degree of puffiness, colour and texture parameters. Dough sheet thickness had significant effects on tortilla chip quality, although baking time and temperature had the greatest effects. Increasing temperature and time decreased moisture content, water activity and degree of puffiness, but increased hardness, fracturability and brownness index. Among those tested, the best conditions for preparing sorghum tortilla chips were dough sheet thickness of 0.95 mm, baking temperature of 160 °C and baking time of 4 min. The properties of the white sorghum tortilla chips were closer than the red sorghum tortilla chips to those of the corn‐wheat control. The sorghum tortilla chips developed are a healthy gluten‐free snack with favourable physiochemical properties.
Effects of kombucha bacterial cellulose on wheat dough properties
Authors: Wu Jiaqi , Li Li , Ma Sen 
Published: January 2024

SummaryThis study aimed to investigate how kombucha bacterial cellulose (KBC) affects the characteristics of dough. Wheat flour was substituted with different proportions of KBC (0%, 1%, 3%, 5%, 7%, and 9%), and the chemical components of KBC and the mixed powder were analysed at various substitution levels. The findings indicated that using KBC led to extended durations and enhanced stability of dough formation, decreased degree of weakening, increased relaxing time, and significantly reduced peak viscosity, trough viscosity, and final viscosity. Additionally, the process of gelatinisation was impeded. Unlike other dietary fibres, adding low amounts of KBC to flour and dough not only maintains their quality but also improved many other characteristics. When added in low quantities of 1% and 3%, KBC improved various dough properties, including enhancing gluten strength, stabilising the gluten structure, and improving viscoelasticity. Overall, this study provided insights into the impact of KBC on the dough structure.
Professional identity and representations of advanced practice nurses specialising in psychiatry and mental health: A national study
Authors: Damien Croguennec , Marion Darras‐Hostens , Deborah Sebbane , Margot Morgiève 
Published: January 2024

AbstractAdvanced practice nurses constitute a new professional group within the French health care system. Advanced practice nurses specialise in one of five disciplines including Psychiatry/Mental‐Health. This specific discipline is strongly marked by stigmatising representations by healthcare users and other health professionals (including other advanced practice nurses), whose consequences have a deleterious effect. The aim was to highlight all advanced practice nurses representation of Psychiatry/Mental‐Health advanced practice nurses. An observational descriptive survey, based on an anonymous online questionnaire was conducted in April 2022 among qualified and student advanced practice nurses from the five specialist disciplines. Overall, 356 advanced practice nurses completed the survey questionnaire. No significant difference in stigmatising representations of Psychiatry/Mental‐Health advanced practice nurses versus other advanced practice nurses was observed. Only 3.3% of other advanced practice nurses thought that Psychiatry/Mental‐Health advanced practice nurses are often ‘strange’. Psychiatry/Mental‐Health advanced practice nurses and other advanced practice nurses appeared to have similar representations of the professional roles of advanced practice nurses in general and of advanced practice nurses APN specifically. Unlike other professionals in the psychiatric field (e.g. medical interns, nurses), very little stigmatisation of Psychiatry/Mental‐Health advanced practice nurses by their colleagues (i.e. other advanced practice nurses) was observed. This could be partly due to the fact that advanced practice nurses professional identity appeared to be built collectively around the concept of advanced practice. Advanced practice nurses constitute a professional group that is fully involved in contemporary transformations in care and organisational innovation. The very low level of stigmatisation of Psychiatry/Mental‐Health advanced practice nurses by other advanced practice nurses in our study suggests that these new healthcare actors could play a crucial role in the improvement of professional health practices, particularly in terms of improved coordination between psychiatric‐care and physical‐care.
Sleep quality, coping, and related depression: A cross‐sectional study of Turkish nurses
Authors: Topal Kılıncarslan Gülseda , Özcan Algül Ayşegül , Gördeles Beşer Nalan 
Published: January 2024

AbstractBackgroundThe sleep quality of nurses affects both their health and standard of nursing care. Working conditions, depression, and coping potential can also lead to sleep problems.IntroductionSleep plays a crucial role in overall health at every stage of life. The purpose of this study is to determine the effect of sleep quality, depression, and coping mechanisms on the performance of nurses, whose sleep quality is strongly affected due to shift‐based work.MethodsThe sample of this descriptive correlational study consisted of 133 healthcare workers. Data were collected using the Personal Information Form, Beck Depression Inventory (BDI), Coping Response Inventory (CRI), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) and evaluated using the t test, Mann–Whitney U test, one‐way ANOVA, Enter method, and linear regression.FindingsOne in three nurses reported having poor‐quality sleep, and one in two nurses said they felt sleepy during the day. With declining sleep quality, the nurses' ability to cope with stress diminished, and their degree of depression increased.DiscussionThe nurses' financial situation and level of depression were key factors that influenced their quality of sleep and capacity to handle stress. To improve nurses' sleep, the shift pattern needs to change.ConclusionTo increase the quantity of sleep and enhance mental health, changes should be made to the shift schedules of nurses to allow for appropriate rest and reduce daytime sleepiness.Implications for nursing practice and policiesImproved working conditions for nurses and updated nursing standards are required to improve nurses health and wellbeng.
From the mountains to the sea: Rethinking Mediterranean glacial refugia as dynamic entities
Authors: Chiocchio Andrea , Maiorano Luigi , Pezzarossa Alice , Bisconti Roberta , Canestrelli Daniele 
Published: January 2024

AbstractAimGlacial refugia are areas of primary importance for the evolution and conservation of biodiversity. Yet, their geographic location remains loosely defined even in intensively studied areas, preventing a thorough understanding of their role in the spatiotemporal biodiversity dynamics. With this study, we aim to locate the major glacial refugia within the biodiversity hotspot of the Italian peninsula, to understand the processes that warranted the long‐term persistence of biodiversity in the face of climate changes.LocationItalian peninsula.TaxonTerrestrial vertebrates.MethodsWe calibrated species distribution models (SDM) for 22 lineages of terrestrial vertebrates endemic to the Italian peninsula and projected the SDMs to the last‐glacial maximum conditions. Then, we combined single‐lineage projections to investigate the location and spatiotemporal dynamics of multi‐species glacial refugia.ResultsMulti‐species refugia were mostly found in coastal areas that have been flooded by the post‐glacial marine transgressions, and that are currently below the sea level. Indeed, we identified six major areas acting as glacial refugia, mainly located outside the current coastline in the southern part of the peninsula and along the western coast. These areas were close to previously inferred locations of glacial refugia and genetic diversity hotspots, but none coincided with them.ConclusionsResults from this study outline glacial refugia as highly dynamic units. Most of the identified refugial areas have been lost by post‐glacial sea‐level rise. Accordingly, species persistence through the Late Pleistocene was not granted by long‐term environmental stability, but by the opportunity to shift species' distributions along altitudinal gradients, following changes in climate and habitat suitability. Notably, our results decouple glacial refugia from hotspots of genetic diversity. Thus, the current location of a hotspot should not be taken as evidence for the occurrence of a glacial refugium in that location—even though a refugium is likely to be located somewhere nearby.
Hostile activism: Hostile tactics or hostile hedge funds?
Authors: Benedetti Hugo , Nikbakht Ehsan , Spieler Andrew C. 
Published: January 2024

AbstractIn this article, we examine reputation building by activist hedge funds and provide two new findings regarding hostile activism. First, we find evidence of a permanent reputation effect to hostile activism. Activist hedge funds that have engaged in hostile tactics receive on average a 3% higher cumulative abnormal return (CAR) [−10, +10] on their subsequent nonhostile campaigns compared to hedge funds that have not engaged in hostile tactics. This abnormal return is positively related to the level of the hostile reputation of the activist hedge fund. Second, we find that activist hedge funds with higher hostile reputations modify their nonhostile activism style to engage hostile‐like targets and pursue hostile‐like objectives but withhold the use of explicitly hostile tactics. These findings imply that (1) hedge funds can build a hostile reputation using their past engagement tactics and (2) market participants perceive and value such reputation as evidenced by the higher announcement return observed in subsequent targets.
Hepatic arterial infusion chemotherapy combined with lenvatinib and PD‐1 inhibitors versus lenvatinib and PD‐1 inhibitors for HCC refractory to TACE
Authors: Diao Lingfeng , Wang Chendong , You Ran , Leng Bin , Yu Zeyu , Xu Qingyu , Cheng Yuan , Yin Guowen 
Published: January 2024

AbstractBackground and AimThe study aims to investigate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and immune checkpoint inhibitors (ICIs) versus lenvatinib and ICIs for hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) refractoriness.MethodsPatients with intermediate or advanced TACE‐refractory HCC who received lenvatinib and ICIs with or without HAIC between 2020 and 2022 were retrospectively reviewed. The tumor response, overall survival (OS), progression‐free survival (PFS), and treatment‐related adverse events (TRAEs) were evaluated and compared between the two groups. Factors affecting OS and PFS were identified with univariate and multivariate Cox regression analyses.ResultsA total of 121 patients were enrolled, with 58 patients assigned to the HAIC‐Len‐ICI group and 63 patients assigned to the Len‐ICI group. A higher objective response rate and disease control rate were found in the HAIC‐Len‐ICI group than in the Len‐ICI group (48.30% vs 23.80%, P = 0.005; 87.90% vs 69.80%, P = 0.02, respectively). The median OS was 24.0 months in the HAIC‐Len‐ICI group and 13.0 months in the Len‐ICI group (P = 0.001). The median PFS was 13.0 months in the HAIC‐Len‐ICI group and 7.2 months in the Len‐ICI group (P < 0.001). Multivariable analyses suggested that the presence of cirrhosis, Child–Pugh B stage, and HAIC‐Len‐ICI therapy option were prognostic factors for OS and PFS. The incidences of any grade and grade 3/4 TRAEs were both comparable between the two groups.ConclusionsHAIC combined with lenvatinib and ICIs yielded better OS, PFS, ORR, and DCR than lenvatinib‐ICI therapy in patients with HCC refractory to TACE, with manageable adverse events.
Delirium detection tools show varying completion rates and positive score rates when used at scale in routine practice in general hospital settings: A systematic review
Authors: Penfold Rose S. , Squires Charlotte , Angus Alisa , Shenkin Susan D. , Ibitoye Temi , Tieges Zoë , Neufeld Karin J. , Avelino‐Silva Thiago J. , Davis Daniel , Anand Atul , Duckworth Andrew D. , Guthrie Bruce , MacLullich Alasdair M. J. 
Published: January 2024

AbstractBackgroundMultiple short delirium detection tools have been validated in research studies and implemented in routine care, but there has been little study of these tools in real‐world conditions. This systematic review synthesized literature reporting completion rates and/or delirium positive score rates of detection tools in large clinical populations in general hospital settings.MethodsPROSPERO (CRD42022385166).Medline, Embase, PsycINFO, CINAHL, and gray literature were searched from 1980 to December 31, 2022. Included studies or audit reports used a validated delirium detection tool performed directly with the patient as part of routine care in large clinical populations (n ≥ 1000) within a general acute hospital setting. Narrative synthesis was performed.ResultsTwenty‐two research studies and four audit reports were included. Tools used alone or in combination were the Confusion Assessment Method (CAM), 4 ‘A's Test (4AT), Delirium Observation Screening Scale (DOSS), Brief CAM (bCAM), Nursing Delirium Screening Scale (NuDESC), and Intensive Care Delirium Screening Checklist (ICDSC). Populations and settings varied and tools were used at different stages and frequencies in the patient journey, including on admission only; inpatient, daily or more frequently; on admission and as inpatient; inpatient post‐operatively. Tool completion rates ranged from 19% to 100%. Admission positive score rates ranged from: CAM 8%–51%; 4AT 13%–20%. Inpatient positive score rates ranged from: CAM 2%–20%, DOSS 6%–42%, and NuDESC 5–13%. Postoperative positive score rates were 21% and 28% (4AT). All but two studies had moderate–high risk of bias.ConclusionsThis systematic review of delirium detection tool implementation in large acute patient populations found clinically important variability in tool completion rates, and in delirium positive score rates relative to expected delirium prevalence. This study highlights a need for greater reporting and analysis of relevant healthcare systems data. This is vital to advance understanding of effective delirium detection in routine care.
A Qualitative Study of Hospitals and Payers Implementing Community Doula Support
Authors: Gebel Christina , Larson Elysia , Olden Heather A. , Safon Cara B. , Rhone Tonia J. , Amutah‐Onukagha Ndidiamaka N. 
Published: January 2024

IntroductionThe impact of doula care on birth outcomes is well‐established; however, doula support remains underutilized. Identifying barriers and facilitators to implementation is integral as the demand for doula care increases. The primary objective of this study was to examine doula program implementation across hospitals and payers at varying stages of implementation.MethodsRepresentatives from 4 hospitals and 2 payers participated in focus group discussions. The doula programs were categorized as anticipated, initial, and advanced implementation statuses. Coding and thematic analysis were conducted using a deductive application of the Consolidated Framework for Implementation Research.ResultsThere were 20 participants across 5 focus group discussions. Participants were mostly female, and nearly all had worked at their organization for at least 2 years. Salient themes shared across participants included valuing internal outcome data or peer‐reviewed literature to support doula care as well as anecdotal stories; the reality of the resource‐intensive nature of doula care implementation that goes beyond funding for doulas; and both the need for individual champions for change, such as midwives, and a supportive organizational culture that values health equity.DiscussionThe findings of this study highlight 3 contextual aspects that should be considered when implementing doula programs. These recommendations include: (1) use of a combination of research evidence and anecdotes when eliciting stakeholder support; (2) consideration of resources beyond funding such as program implementation support; (3) critical evaluation of organizational culture as a primary driver influencing the implementation of doula care. The future of the doula workforce in United States hospitals rests on the crux of intentional buy‐in from hospital administration and clinical providers as well as the availability of requisite resources.
The German version of the Oxford Cognitive Screen (D‐OCS): Normative data and validation in acute stroke and a mixed neurological sample
Authors: Bormann Tobias , Kaller Christoph P. , Kulyk Caterina , Demeyere Nele , Weiller Cornelius 
Published: January 2024

AbstractGiven the frequency of stroke worldwide, tools for neuropsychological assessment of patients with acute stroke are needed to identify cognitive impairments, guide rehabilitation efforts and allow for a prognosis of outcome. However, requirements for assessment tools for acute cognitive deficits differ substantially from tests for chronic neuropsychological impairments and screening tools for suspected dementia. The Oxford Cognitive Screen (OCS) has been developed as a quick to administer neurocognitive screening for acute neurological patients providing information on various cognitive domains. It is available in different languages. The present study reports cut‐off scores, parallel‐test reliability and concurrent validity of the German version (D‐OCS). Following standardized language adaptation and translation, the D‐OCS was administered to 100 healthy individuals to generate cut‐off scores (5th percentile). Subsequently, 88 neurological patients were assessed with both versions of the D‐OCS as well as other tests to evaluate reliability and validity of the D‐OCS subscales. In a further study, the D‐OCS was compared to the MoCA test in 65 acute stroke patients revealing comparable sensitivity but also differences between both tools. The cut‐off scores were comparable to other international versions of the OCS. Intraclass correlations were highly significant and document reliability of the D‐OCS subtests. Scores on subtests correlated significantly with independent tests securing validity. Comparison with the MoCA revealed comparable sensitivity and specificity. The D‐OCS is a reliable and valid assessment tool well suited for patients with acute stroke. Differences to the MoCA test are discussed.
Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti‐signalling protein (asip1) overexpression in zebrafish
Authors: Godino‐Gimeno Alejandra , Leal Esther , Chivite Mauro , Tormos Elisabeth , Rotllant Josep , Vallone Daniela , Foulkes Nicholas S. , Míguez Jesús M. , Cerdá‐Reverter Jose Miguel 
Published: January 2024

AbstractTemporal signals such as light and temperature cycles profoundly modulate animal physiology and behaviour. Via endogenous timing mechanisms which are regulated by these signals, organisms can anticipate cyclic environmental changes and thereby enhance their fitness. The pineal gland in fish, through the secretion of melatonin, appears to play a critical role in the circadian system, most likely acting as an element of the circadian clock system. An important output of this circadian clock is the locomotor activity circadian rhythm which is adapted to the photoperiod and thus determines whether animals are diurnal or nocturnal. By using a genetically modified zebrafish strain known as Tg (Xla.Eef1a1:Cau.asip1)iim04, which expresses a higher level of the agouti signalling protein 1 (Asip1), an endogenous antagonist of the melanocortin system, we observed a complete disruption of locomotor activity patterns, which correlates with the ablation of the melatonin daily rhythm. Consistent with this, in vitro experiments also demonstrated that Asip1 inhibits melatonin secretion from the zebrafish pineal gland, most likely through the melanocortin receptors expressed in this gland. Asip1 overexpression also disrupted the expression of core clock genes, including per1a and clock1a, thus blunting circadian oscillation. Collectively, these results implicate the melanocortin system as playing an important role in modulating pineal physiology and, therefore, circadian organisation in zebrafish.