bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study
Authors: Petty Alice , Garcia-Hidalgo Anna , Halff Els F , Natesan Sridhar , Withers Dominic J , Irvine Elaine E , Kokkinou Michelle , Wells Lisa A , Bonsall David R , Tang Sac-Pham , Veronese Mattia , Howes Oliver D 
Published: October 2023

Abstract
Purpose
There is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. This finding comes from positron emission tomography (PET) studies using radiolabelled l-3,4-dihydroxyphenylalanine (18F-DOPA). DA synthesis capacity also appears to be elevated in the midbrain of people with schizophrenia compared to healthy controls. We therefore aimed to optimise a method to quantify 18F-DOPA uptake in the midbrain of mice, and to utilise this method to quantify DA synthesis capacity in the midbrain of the sub-chronic ketamine model of schizophrenia-relevant hyperdopaminergia.

Procedures
Adult male C57Bl6 mice were treated daily with either ketamine (30 mg/kg, i.p.) or vehicle (saline) for 5 days. On day 7, animals were administered 18F-DOPA (i.p.) and scanned in an Inveon PET/CT scanner. Data from the saline-treated group were used to optimise an atlas-based template to position the midbrain region of interest and to determine the analysis parameters which resulted in the greatest intra-group consistency. These parameters were then used to compare midbrain DA synthesis capacity (KiMod) between ketamine- and saline-treated animals.

Results
Using an atlas-based template to position the 3.7 mm3 midbrain ROI with a T*–Tend window of 15–140 min to estimate KiMod resulted in the lowest intra-group variability and moderate test–retest agreement. Using these parameters, we found that KiMod was elevated in the midbrain of ketamine-treated animals in comparison to saline-treated animals (t(22) = 2.19, p = 0.048). A positive correlation between DA synthesis capacity in the striatum and the midbrain was also evident in the saline-treated animals (r2 = 0.59, p = 0.005) but was absent in ketamine-treated animals (r2 = 0.004, p = 0.83).

Conclusions
Using this optimised method for quantifying 18F-DOPA uptake in the midbrain, we found that elevated striatal DA synthesis capacity in the sub-chronic ketamine model extends to the midbrain. Interestingly, the dysconnectivity between the midbrain and striatum seen in this model is also evident in the clinical population. This model may therefore be ideal for assessing novel compounds which are designed to modulate pre-synaptic DA synthesis capacity.
Impact of different processing techniques (chemical, heating and sonication) on physicochemical and microbial characterization of kinnow-whey based beverage
Authors: Siddique Farzana , Hussain Ashiq , Noreen Saima , Arif Muhammad Rehan , Yaqub Shazia , Batool Syeda Ayesha , Iqbal Aqsa , Fatima Haya , Gorsi Faiza Iftikhar , Iqbal Ammad , Korma Sameh A. , Mahdi Amer Ali 
Published: October 2023

AbstractWhey beverages that have been added with fruits pulp have always been remained the priority demand of food consumers, but loss of nutritional contents and microbial safety of such beverages is always matter of concern of food producers. To overcome these issues food experts are always in try to find out the processing and preservation techniques for safety of these beverages. In present study kinnow-whey beverage was prepared by addition of kinnow concentrate and acidic whey, at optimum concentrations. Effect of different processing techniques on the physicochemical properties, microbial inactivation, and sensory characteristics of beverage were investigated during 90 days of storage. The outcomes of pasteurization were compared with non-thermal techniques, such as use of preservatives and sonication (20 kHz frequency, 70% amplitude and 5, 10 and 15 min). pH values of all the treatments were reduced, whereas titratable acidity was increased significantly, during storage. There was a significant increase in the brix, viscosity and total solids, with the increase in the storage period. Highest values obtained for brix, viscosity and total solids were T3 (14.32°), T3 (15.13 cP), and T3 (15.13 mg/L) after 90 days storage, respectively. Total plate count (TPC) and yeast and mold count were increased during prolong storage in all treatments. Results showed that the maximum TPC was noted in T0 (2.9 × 104 cfu/ml) at 90 days, while minimum TPC was observed in T5 (0.8 × 104 cfu/ml) at start of study. Similarly, maximum yeast and mold count were noted in T1 (3.2 × 104 cfu/ml) at 90 days whereas, minimum yeast and mold count was observed in T5 (0.1 × 104 cfu/ml) at start of study. Overall acceptability of beverage was highest in 15 min sonicated treatments. It was concluded that the beverages processed with sonication (15 min) demonstrated better stability and sensory attributes compared to other techniques.
RETRACTED ARTICLE: A Hierarchical Algorithm Model for the Scheduling Problem of Cold Chain Logistics Distribution Vehicles Based on Machine Vision
Authors: Sun Yingsun 
Published: October 2023

AbstractWith the continuous development of the market economy, the professional degree of the logistics industry is constantly improving, while the logistics distribution industry is also developing rapidly. The logistics distribution of the cold chain supply chain involves multiple distribution points, and the distance and time relationship between the distribution points are often not fully considered in the route planning, resulting in low distribution efficiency. The hierarchical algorithm model based on machine vision can solve the above problems to a certain extent. This paper takes two cold chain supply chain enterprises as the main research body, analyzes how to choose two kinds of COD and CCD sensors using machine vision, and the number of distribution vehicle scheduling. The simulation experiment was performed and at the end of the article it is summarized and discussed. According to the data sample, the two enterprises have the largest number of people satisfied with the supply chain logistics and distribution vehicle scheduling, but the number of people dissatisfied with enterprise A is 6 and 12% of the total. The number of people dissatisfied with enterprise B is 16 and 32% of the total number, It can be seen that although the number of people satisfied with the two enterprises is large, the number of people dissatisfied with enterprise B far exceeds that of enterprise A. At the same time, with the continuous research of supply chain logistics distribution vehicle scheduling, the research on machine vision is also facing new opportunities and challenges.
Investigating mechanosensitive channels activation in concert with the mechanical properties of red blood cells
Authors: Braidotti Nicoletta , Ciubotaru Catalin Dacian , Rizzo Davide , Bergamo Lorenzo , Bernareggi Annalisa , Cojoc Dan 
Published: October 2023

AbstractThe activity of the mechanosensitive Ca2+ permeable channels expressed in the membrane of the red blood cells (RBC) is determined both by the mechanical stimuli and the mechanical properties of the cell. Therefore, it is of most importance to correlate the triggering stimulus with the mechanical properties. In this paper, we propose an approach to determine the activation pressure of the mechanosensitive channels and concomitantly evaluate cell mechanical properties as Young’s Modulus, membrane tension and viscosity, for individual cells. Cell deformation was accomplished by micropipette aspiration with a controlled pressure ramp and recorded by brightfield imaging to determine the mechanical properties. The Ca2+ transient was concomitantly monitored by fluorescence imaging, to get the activation pressure. The technique was validated comparing the behavior of three pools of RBCs, probed at different intervals of time after the cell suspension preparation by the same mechanical stimuli. We found relevant changes of the activation pressure, associated with the alteration of the mechanical properties, the latest becoming significant with the passage of time. Our approach opens a new direction to investigate the correlation between mechanosensitivity and mechanical properties for individual RBCs, which can be extended to other cells, in suspension or plated, under controlled environmental conditions.
Blue carbon gain by plant invasion in saltmarsh overcompensated carbon loss by land reclamation
Authors: Zhou Jinge , Zhang Jingfan , Chen Yaping , Qin Guoming , Cui Bo , Lu Zhe , Wu Jingtao , Huang Xingyun , Thapa Poonam , Li Hui , Wang Faming 
Published: October 2023

AbstractSaltmarsh is a major contributor to global blue carbon (C) sink. However, plant invasion and anthropic activities have greatly altered its distribution and its blue C function in the last decades. We used remote sensing and data synthesis to investigate how the four decades of plant invasion and land reclamation affect the spatiotemporal variation of blue C in Yancheng saltmarshes, the largest coastal ecosystem in eastern China. We revealed that the invasion of exotic cordgrass, Spartina alterniflora, greatly increased the regional blue C storage, mainly by the seaward expansion of cordgrass in mudflats and its high ecosystem C stock. The iconic Suaeda salsa “Red Beach” marshes shrank by 90%, mainly due to reed occupation by the native reed, Phragmites australis. Phragmites australis marsh area was greatly occupied by reclamation, but well offset by its intrusion into Suaeda salsa. The blue C gain by cordgrass invasion overcompensated C loss due to land reclamation and the loss of “Red Beach”. Our findings highlight that coastal blue C is greatly regulated by vegetation coverage, and the seaward cordgrass invasion can benefit the saltmarsh C sequestration. Such a similar process may apply in other regions of the world, with potentially large implications for blue C sinks.
Graphical Abstract
What is the Cow-Calf Economics of Genetic Panel Scores for Feedlot Traits?
Authors: Garrison Greg L. , Brorsen B. Wade , Biermacher Jon T. , DeVuyst Eric A. , Bancroft Andrew , Whitley Evan M. 
Published: October 2023

AbstractPast research has only studied genetic panel scores and feedlot performance. This research combines impacts of genetic panel scores on a cow-calf operation with previously estimated feedlot impacts to evaluate the potential for misaligned economic incentives in the beef industry. Calves that were higher genetic scores for two carcass traits, marbling and tenderness, had lower weaning weights and lower net returns. Correlations between genetic traits and cow size were small and mostly insignificant. The sum of the effects on feedlot and cow-calf sectors of a one-unit higher panel score totaled $-2.83 per cow year for marbling and $-4.93 per cow year for tenderness.
Case study of semaglutide and cardiovascular outcomes: An application of the Causal Roadmap to a hybrid design for augmenting an RCT control arm with real-world data
Authors: Dang Lauren E. , Fong Edwin , Tarp Jens Magelund , Clemmensen Kim Katrine Bjerring , Ravn Henrik , Kvist Kajsa , Buse John B. , van der Laan Mark , Petersen Maya 
Published: October 2023

Abstract

Introduction:
Increasing interest in real-world evidence has fueled the development of study designs incorporating real-world data (RWD). Using the Causal Roadmap, we specify three designs to evaluate the difference in risk of major adverse cardiovascular events (MACE) with oral semaglutide versus standard-of-care: (1) the actual sequence of non-inferiority and superiority randomized controlled trials (RCTs), (2) a single RCT, and (3) a hybrid randomized-external data study.

Methods:
The hybrid design considers integration of the PIONEER 6 RCT with RWD controls using the experiment-selector cross-validated targeted maximum likelihood estimator. We evaluate 95% confidence interval coverage, power, and average patient time during which participants would be precluded from receiving a glucagon-like peptide-1 receptor agonist (GLP1-RA) for each design using simulations. Finally, we estimate the effect of oral semaglutide on MACE for the hybrid PIONEER 6-RWD analysis.

Results:
In simulations, Designs 1 and 2 performed similarly. The tradeoff between decreased coverage and patient time without the possibility of a GLP1-RA for Designs 1 and 3 depended on the simulated bias. In real data analysis using Design 3, external controls were integrated in 84% of cross-validation folds, resulting in an estimated risk difference of –1.53%-points (95% CI –2.75%-points to –0.30%-points).

Conclusions:
The Causal Roadmap helps investigators to minimize potential bias in studies using RWD and to quantify tradeoffs between study designs. The simulation results help to interpret the level of evidence provided by the real data analysis in support of the superiority of oral semaglutide versus standard-of-care for cardiovascular risk reduction.
Post-crisis Emergency Legislation Consolidation: Regulatory Quality Principles for Good Times Only?
Authors: Staronova Katarina , Lacková Nina , Sloboda Matúš 
Published: October 2023

AbstractThis article analyses how emergency legislation has affected law-making and regulatory quality principles (RQPs) before, during and after the COVID-19 pandemic (2019–2021) from stakeholders’ perspectives. It takes Slovakia as a case study, as this country was considered a high performer in the adoption of RQPs before the crisis, while empirical findings suggest a subsequent decline in their use. We argue that formal RQPs are not deeply embedded and are vulnerable to crises. In doing so, we conceptually distinguish between standard (fully following the RQPs), emergency (modified to accommodate crisis) and non-standard law-making (violating formal rules and the RQPs). In the transition from a crisis to a post-crisis context, the deployment of both emergency and non-standard law-making has become relatively permanent without proper justification having been provided. This reinforces the notion that RQPs and governance legitimacy became less important for the executive than in the pre-crisis period and emergency and non-standard regulatory law-making became institutionalised as new norms of swift law-making. All of these factors prevent stakeholders from being informed and from engaging in deliberation, which jeopardises the legitimacy of post-crisis law-making governance.
Against Defending Science: Asking Better Questions About Indigenous Knowledge and Science
Authors: Parke Emily C. , Hikuroa Daniel 
Published: October 2023

AbstractThis article addresses problems with a defensive turn in discussions of science and Indigenous ways of knowing, being, and doing. Philosophers and practitioners of science have focused recent discussions on coarse-grained questions of demarcation, epistemic parity, and identity—asking questions such as “Is Indigenous knowledge science?” Using representative examples from Aotearoa New Zealand, we expose rampant ambiguities in these arguments, and show that this combative framing can overlook what is at stake. We provide a framework for analyzing these problems and suggest better ways forward.
Social Dynamics and the Evolution of Disciplines
Authors: Wong Kekoa , Rubin Hannah 
Published: October 2023

AbstractWe consider the long-term evolution of science and show how a “contagion of disrespect”—an increasing dismissal of research in subfields associated with marginalized groups—can arise due to the dynamics of collaboration and reputation (versus, e.g., preconceived notions of the field’s worth). This has implications both for how we understand the history of science and for how we attempt to promote diverse scientific inquiry.
The 1991 review by Coen and Meyerowitz on the war of the whorls and the ABC model of floral organ identity
Authors: Schneitz Kay 
Published: October 2023

Abstract
The 1991 review paper by Coen and Meyerowitz on the control of floral organ development set out the evidence available at that time, which led to the now famous ABC model of floral organ identity control. The authors summarised the genetic and molecular analyses that had been carried out in a relatively short time by several laboratories, mainly in Arabidopsis thaliana and Antirrhinum majus. The work was a successful example of how systematic genetic and molecular analysis can decipher the mechanism that controls a developmental process in plants. The ABC model is a combinatorial model in which each floral whorl acquires its identity through a unique combination of floral homeotic gene activities. The review also highlights the similarities in the regulation of floral organ identity between evolutionarily distant plant species, emphasising the general relevance of the model and paving the way for comprehensive studies of the evolution of floral diversity.
Plant-based diets benefit aerobic performance and do not compromise strength/power performance: a systematic review and meta-analysis
Authors: Damasceno Yancka Oliveira , Leitão Cauã V. F. S. , de Oliveira Gabriel Moraes , Andrade Fernando Augusto Barcelos , Pereira André B. , Viza Rodrigo S. , Correia Renata C. , Campos Helton O. , Drummond Lucas R. , Leite Laura H. R. , Coimbra Cândido C. 
Published: October 2023

AbstractPlant-based diets have emerged as athletic performance enhancers for various types of exercise. Therefore, the present study evaluated the effectiveness of plant-based diets on aerobic and strength/power performances, as well as on BMI of physically active individuals. This systematic review and meta-analysis was conducted and reported according to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. A systematic search of electronic databases, including PubMed, Web of Science and SPORTDiscus, was performed. On the basis of the search and inclusion criteria, four and six studies evaluating the effects of plant-based diets on aerobic and strength/power performances in humans were, respectively, included in the systematic review and meta-analysis. Plant-based diets had a moderate but positive effect on aerobic performance (0·55; 95 % CI 0·29, 0·81) and no effect on strength/power performance (–0·30; 95 % CI −0·67, 0·07). The altogether analyses of both aerobic and strength/power exercises revealed that athletic performance was unchanged (0·01; 95 % CI −0·21, 0·22) in athletes who adopted plant-based diets. However, a small negative effect on BMI (–0·27; 95 % CI −0·40, –0·15) was induced by these diets. The results indicate that plant-based diets have the potential to exclusively assist aerobic performance. On the other hand, these diets do not jeopardise strength/power performance. Overall, the predicted effects of plant-based diets on physical performance are impactless, even though the BMI of their adherents is reduced.
Classification of subpencils for hyperplane sections on certain K3 surfaces
Authors: Takahashi Tomokuni 
Published: October 2023

AbstractWe classify the subpencils of complete linear systems for the hyperplane sections on K3 surfaces obtained as the complete intersection of a hyperquadric and a hypercubic. The classification is done from three points of view, namely, the type of a general fibre, the base locus and the Horikawa index of the essential member. This classification shows the distinct phenomenons depending on the rank of the hyperquadrics containing the surface.
Stable solutions to double phase problems involving a nonlocal term
Authors: Rahal Belgacem , Le Phuong 
Published: October 2023

AbstractIn this paper, we study weak solutions, possibly unbounded and sign-changing, to the double phase problem
\begin{equation*}
-\text{div} (|\nabla u|^{p-2} \nabla u + w(x)|\nabla u|^{q-2} \nabla u) = \left(\frac{1}{|x|^{N-\mu}}*f|u|^r\right) f(x)|u|^{r-2}u \quad\text{in}\ \mathbb{R}^N,
\end{equation*}
where $q\ge p\ge2$, r > q, $0 \lt \mu \lt N$ and $w,f \in L^1_{\rm loc}(\mathbb{R}^N)$ are two non-negative functions such that $w(x) \le C_1|x|^a$ and $f(x) \ge C_2|x|^b$ for all $|x| \gt R_0$, where $R_0,C_1,C_2 \gt 0$ and $a,b\in\mathbb{R}$. Under some appropriate assumptions on p, q, r, µ, a, b and N, we prove various Liouville-type theorems for weak solutions which are stable or stable outside a compact set of $\mathbb{R}^N$. First, we establish the standard integral estimates via stability property to derive the non-existence results for stable weak solutions. Then, by means of the Pohožaev identity, we deduce the Liouville-type theorem for weak solutions which are stable outside a compact set.
Household Matters: Engendering the Social History of Capitalism
Authors: Boris Eileen , Swinth Kirsten 
Published: October 2023

AbstractThis essay takes up the project of engendering capitalism by turning to the household. It situates a gendered analysis of capitalism within recent histories of capitalism, feminist analyses of social reproduction, histories of family and industrialism, histories of sexuality, and histories of women's labor. It argues that to analyze capitalism from a household perspective clarifies three core elements of capitalist political economy. First, capitalism depended on reproductive and productive labor inside the household, from early industrialization through its most recent incarnations. Second, reproductive labor, historically anchored in the household, has served as a crucial site for development of capitalist labor relations. Third, that intensified commodification of reproductive labor has driven capitalist accumulation as well as capitalist social relations, whether that labor occurs within the household or is located beyond it.
Overlapping Ownership Along the Supply Chain
Authors: Freeman Kayla M. 
Published: October 2023

Abstract
I find overlapping institutional ownership (OIO) in a customer and supplier increases the duration of their supply chain relationship. Results are stronger when vertical holdup is more severe. A quasi-natural experiment around mergers of financial institutions provides causal evidence of OIO improving relationship survival rates. Concurrent with longer-lived relationships, valuations and innovation increase, consistent with OIO effects on relationship longevity being beneficial. I find evidence of OIO strengthening relationships via an internalization channel: With more OIO, partners cooperate more, with the supplier extending more trade credit. Overall, results indicate OIO strengthens vertical relationships by alleviating holdup problems.
Size-dependent predation on juvenile sandfish, Holothuria scabra by seagrass-associated crabs
Authors: Caasi Olivier Josh C. , Gosselin Louis A. , Juinio-Meñez Marie Antonette 
Published: October 2023

Abstract
High mortality of juvenile Holothuria scabra in seagrass nursery areas has been attributed to predation. In this study, laboratory and field experiments were conducted to determine the effect of the size of two seagrass–associated crabs, Thalamita crenata and Dardanus megistos, on the survival of juvenile sandfish at different sizes (1–10 g). Small juvenile sandfish (1–2 g) offered in field trials were more preferred by small Thalamita and large Dardanus. Non-lethal damage caused by both crabs were also evident, indicating differences in the mode of attack and consumption. The incidence of non-lethal wounds in medium and large juveniles in the laboratory indicate higher incidences of unsuccessful attacks by the crabs. Differences in consumption rate may be related to cheliped morphology and handling techniques, and activity patterns affecting encounter rates. Mortality rates of juvenile sandfish due to T. crenata (CW: 4.30–7.05 cm) ranged from 10–43%, while those by D. megistos (SL: 0.90–2.3 cm) was even higher at 34–53% after 24 h trials. This is the first report that a hermit crab D. megistos is a significant predator of juvenile sandfish. Results provide new insights on crab–soft-bodied prey interactions in tropical seagrass areas. These are also important considerations in stock restoration and ocean-based culture. Given that juveniles (≤10 g) are very vulnerable to predation by these common crab species, growing sandfish to larger sizes is essential prior to release in the field.