bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photocatalytic degradation of 4‐nitrophenol by using multicomponent Cu2O‐Cu@TiO2 nanoparticle aggregates
Authors: Jiang Jianwei , Moon Seokyeong , Yoon Sungho , Piao Longhai 
Published: February 2024

AbstractMulticomponent nanomaterials with synergistic effect were typically used to enhance the photocatalytic performance. Herein, three‐component nanomaterials composed of Cu2O, Cu, and TiO2 were prepared using a facile method, and applied in the photocatalytic degradation reactions. The synthetic procedure involves the formation of Cu2O nanoparticle aggregates (NPAs) followed by Cu nanoparticles growth on the surface of Cu2O NPAs in one pot, and TiO2 encapsulation (Cu2O‐Cu@TiO2). The catalyst structure was characterized by x‐ray diffraction, field emission‐scanning electron microscopy, transmission electron microscopy, and energy‐dispersed x‐ray. The catalytic performance of Cu2O‐Cu@TiO2 NPAs was evaluated through the photocatalytic degradation of 4‐nitrophenol under the simulated solar light. We found that it exhibited greater activity than the Cu2O‐Cu NPAs, commercial TiO2, and Cu2O@TiO2 NPAs, probably due to their synergistic interactions resulting in the effective photogenerated carrier transfer in the multicomponent nanomaterials.
Secondary bladder and colorectal cancer after treatments for prostate cancer: A population based study
Authors: Bárcena Patricia Grisel Quintana , Aprikian Armen Garo , Dragomir Alice 
Published: February 2024

AbstractBackgroundProstate cancer (PCa) patients receiving radiotherapy may be predisposed to secondary malignancies. This study aimed to determine the association between PCa treatments, including radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT) and androgen deprivation therapy (ADT); and secondary bladder and colorectal cancer.MethodsA cohort study was constructed using Quebec administrative databases (Med‐Echo and RAMQ). Included men were diagnosed and treated for PCa between 2000 and 2016. Patients with bladder or colorectal cancer prior to PCa were excluded. Follow‐up ended at the earliest of the following: incidence of bladder or colorectal cancer, death, or December 31, 2016. EBRT, BT, EBRT+ADT, RP + ADT or ADT only were compared individually to RP. The incidence of secondary bladder and colorectal cancer were computed. Inverse probability of treatment weighting (IPTW) based on a propensity score was used to control for potential confounding. IPTW‐Cox proportional hazards models were used.ResultsA significant association was found between secondary bladder cancer and EBRT (HR: 1.84, 95%CI: 1.60;2.13), and also EBRT+ADT (HR: 2.08, 95%CI: 1.67;2.56), but not with BT (HR: 1.36, 95%CI: 0.68;2.74). Secondary colorectal cancer was significantly associated to either EBRT (HR: 1.36, 95%CI: 1.21;1.53); or BT (HR: 2.46, 95%CI: 1.71;3.54). The association between ADT alone and both secondary cancers was also significant (HR: 1.98, 95%CI: 1.69;2.31 and HR: 1.69, 95%CI: 1.49;1.92, respectively).ConclusionsCompared to PCa patients undergoing RP, the secondary bladder cancer was associated with EBRT, ADT, alone or in combination. The secondary colorectal cancer was also associated with receiving either EBRT, BT or ADT.
Molecular Docking and GC/MS‐Based Approach for Identification of Anxiolytic Alkaloids from Griffinia (Amaryllidaceae) Species in a Zebrafish Model
Authors: Leite Elder Luis Lima , Sheila de Queiroz Souza Ana , Riceli Vasconcelos Ribeiro Paulo , de Cássia Alves Pereira Rita , Florêncio Martins Natália , Kueirislene Amâncio Ferreira Maria , Silva Alencar de Menezes Jane Eire , Silva dos Santos Hélcio , Deusdênia Loiola Pessoa Otília , Marques Canuto Kirley 
Published: February 2024

AbstractGriffinia gardneriana Ravenna, Griffinia liboniana Morren and Griffinia nocturna Ravenna (Amarillydaceae) are bulbous plants found in tropical regions of Brazil. Our work aimed to determine the alkaloid profiles of Griffinia spp. and evaluate their anxiolytic potential through in vivo and in silico assays. The plants grown in greenhouses were dried and their ground bulbs were subjected to liquid‐liquid partitions, resulting in alkaloid fractions that were analyzed by gas chromatography coupled to mass spectrometry (GC‐MS). Anxiolytic activity was evaluated in zebrafish (Danio rerio) through intraperitoneal injection at doses of 40, 100 and 200 mg/kg in light‐dark box test. GC‐MS analyses revealed 23 alkaloids belonging to different skeleton types: lycorine, homolychorine, galanthamine, crinine, haemanthamine, montanine and narcisclasine. The chemical profiles were relatively similar, presenting 8 alkaloids common to the three species. The major component for G. gardneriana and G. liboniana was lycorine, while G. nocturna consisted mainly of anhydrolycorine. All three alkaloid fractions demonstrated anxiolytic effect. Furthermore, pre‐treatment with diazepam and pizotifen drugs was able to reverse the anxiolytic action, indicating involving the GABAergic and serotonergic receptors. Molecular docking showed that the compounds vittatine, lycorine and 11,12‐dehydro‐2‐methoxyassoanine had high affinity with both receptors, suggesting them to be responsible for the anxiolytic effect.
Design, Synthesis, and Molecular Docking of Novel Miscellaneous Chalcones as p38α Mitogen‐Activated Protein Kinase Inhibitors
Authors: Zeid Mai M. , El‐Badry Osama M. , Elmeligie Salwa , Hassan Rasha A. 
Published: February 2024

AbstractNew chalcones were synthesized and evaluated to serve as p38‐α type of mitogen‐activated protein kinase (MAPK) inhibitors. According to the National Cancer Institute, the findings indicated that at a 10 μM dosage, compounds 3a and 6 were the most active among all the compounds examined, with mean growth inhibition% of 94.83 and 58.49, respectively. In 5‐dose testing, they showed anticancer activity in the micro‐molar range with GI50 in the range of 1.41–46.1 and 2.07–31.3 μM, respectively. Besides, powerful activity, especially against the leukaemia cell lines and good selectivity to cancer cells compared to normal PCS‐800‐017 with a selectivity index=12.41 and 23.77, respectively. Compounds 3a and 6 inhibited p38α MAPK with IC50 values of 0.1462±0.0063 and 0.4356±0.0189 μM, correspondingly. 3a showed good inhibition for HL‐60(TB) cells and induced cell cycle arrest in HL‐60(TB) cells at the G2/M phase. Besides, it elevated the total apoptosis by 14.68‐fold and increased the caspase‐3 level by 3.52‐fold compared with doxorubicin, which raised it by 4.30‐fold, inducing apoptosis by acting as caspase‐dependent inducers. These results suggest that 3a is a promising antiproliferative and p38α MAPK inhibitor, confirmed by molecular docking with high compatibility 3a with the p38α MAPK binding site.
Histological study of telocytes in mice intrauterine adhesion model and their positive effect on mesenchymal stem cells in vitro
Authors: Wei Xiaojiao , Li Hui , Chen Tianquan , Yang Xiaojun 
Published: February 2024

AbstractIntrauterine adhesions (IUA), the main cause of secondary infertility in women, result from irreversible fibrotic repair of the endometrium due to inflammation or human factors, accompanied by disruptions in the repair function of endometrial stem cells. This significantly impacts the physical and mental health of women in their childbearing years. Telocytes (TCs), a distinctive type of interstitial cells found in various tissues and organs, play diverse repair functions due to their unique spatial structure. In this study, we conduct the inaugural exploration of the changes in TCs in IUA disease and their potential impact on the function of stem cells. Our results show that in vivo, through double immunofluorescence staining (CD34+/Vimentin+; CD34+/CD31−), as endometrial fibrosis deepens, the number of TCs gradually decreases, telopodes shorten, and the three‐dimensional structure becomes disrupted in the mouse IUA mode. In vitro, TCs can promote the proliferation and cycle of bone mesenchymal stem cells (BMSCs) by promoting the Wnt/β‐catenin signaling pathway, which were inhibited using XAV939. TCs can promote the migrated ability of BMSCs and contribute to the repair of stem cells during endometrial injury. In addition, TCs can inhibit the apoptosis of BMSCs through the Bcl‐2/Bax pathway. In conclusion, our study demonstrates, for the first time, the resistance role of TCs in IUA disease, shedding light on their potential involvement in endometrial repair through the modulation of stem cell function.
Concepts behind the Redox Photocatalysis with Quantum Dots
Authors: Navarro Marcelo , Costa Jadielson , Sousa Felipe L. N. 
Published: February 2024

AbstractIn this conceptual review, we present the optical and electronic characteristics of quantum dots for the designing of organic synthesis experiments through the photocatalysis. We discuss the control parameters associated to the charge recombination processes on the semiconductor interface. The positioning of bands and control of intragap states, such as charge donors and acceptors, can define the performance of faradaic processes. Electrochemical strategies, such as voltammetry, can be used as a powerful tool for the determining of the electronic band edges with good precision.
Impact of prophylactic central lymph node dissection on the complications and recurrence rates in papillary thyroid carcinoma—An AFCE (French‐speaking Association of Endocrine Surgery) multicentre study based on the EUROCRINE® national data
Authors: Chereau Nathalie , Christou Niki , Caiazzo Robert , Le Fouler Adrien , Lifante Jean Christophe , Maillard Laure , Mirallie Eric , Pattou Francois , Bouviez Nicolas , Santucci Nicolas , Brunaud Laurent , Menegaux Fabrice 
Published: February 2024

AbstractBackgroundProphylactic central neck dissection (pCND) remains controversial during the initial surgery for preoperative and intraoperative node‐negative (cN0) papillary thyroid carcinoma (PTC).MethodsPatients undergoing thyroidectomy with or without pCND (Nx) for PTC in nine French surgical departments, registered in the EUROCRINE® national data in France between January 2015 and June 2021, were included in a cohort study. Demographic and clinicopathological characteristics, complications, and recurrence rates were compared using multivariate regression analysis.ResultsA total of 1905 patients with cN0 PTC were enrolled, including 1534 who had undergone pCND and 371 who hadn't (Nx). Of these, 1546 (81.2%) were female, and the median age was 49 years (range: 15–89 years). Patients who had undergone pCND were more likely to have multifocal tumors (n = 524 [34.2%] vs. n = 68 [18.3%], p < .001) and larger tumors (15.3 vs. 10.2 mm, p = .01) than patients with Nx. Of the patients with pCND, 553 (36%) had positive central LN (N1a), with a median of 1 N1 (IQR 0–5). pCND was associated with a higher temporary hypocalcemia rate (n = 25 [8%] vs. n = 15 [4%], p < .001). The rates of permanent hypocalcemia and temporary and permanent recurrent laryngeal nerve (RLN) palsy were not significantly different between the two groups (p > .2). After adjusting for covariates (age, sex, multifocality, and pathological T stage) in a multivariable Cox PH model, the performance of lymph node dissection (pCND vs. no‐pCND) was not associated with PTC recurrence (p = .2).ConclusionpCND in PTC does not reduce recurrence and is associated with a two‐fold increase in the incidence of transient hypoparathyroidism. These data should be considered while issuing further guidelines regarding the treatment of patients with cN0 PTC.
Screening tools combined with multivariate data analysis to predict or confirm virgin olive oil classification by the Panel test
Authors: Grigoletto Ilaria , Casadei Enrico , Panni Filippo , Valli Enrico , Cevoli Chiara , Bendini Alessandra , García‐González Diego Luis , Focante Francesca , Savino Angela Felicita , Carpino Stefania , Gallina Toschi Tullia 
Published: February 2024

AbstractA particular aspect of quality control of virgin olive oil (VOO) is the mandatory application, together with chemical and instrumental determinations, of a standardized and official method for sensory assessment. The latter, known as Panel test, is carried out by trained assessors and contributes to the classification of VOOs into three commercial categories (extra virgin, virgin, and lampante). One drawback of this method is related to the large number of samples to be analyzed, compared to the work capacity of a sensory panel, especially during the selection for purchase by companies that blend and market virgin oils and the quality control conducted by the authorities to verify the declared commercial category. For this reason, it is helpful to develop and validate robust and rapid screening methods, based on volatile fingerprints, to preclassify each sample into one of the three commercial categories. Considering the strict relation between volatile compounds and the main sensory attributes (fruity and defects), a gas‐chromatographic volatile fingerprint can be the right choice. In this paper, the comparison of two emerging techniques, namely, headspace‐gas chromatography‐ion mobility spectrometry (HS‐GC‐IMS) and flash‐gas chromatography (FGC), applied on a sample set of 49 VOOs, using calibrations previously built with a larger number of samples, is presented. The number of correctly classified samples, with respect to the commercial category determined by the Panel test, was satisfactory and comparable (92% for HS‐GC‐IMS, and 94% for FGC), confirming the effectiveness of both methods and the robustness of the predictive models.Practical Applications: The demand for rapid screening tools to reduce the number of samples to be assessed by the Panel test has increased in recent years. The validation of robust models and their joint adoption by companies that market VOOs as well as official control bodies could reduce nonconformities and increase the batches of VOO being controlled, thus better protecting the consumer. Therefore, it is desirable to have different tools available to analyze volatile compounds, together with the associated calibration models, along with detailed instructions for their application, to have different alternatives that suit the equipment of individual laboratories.
Implementing coaching programmes for healthcare professionals—A review of the barriers and facilitators
Authors: Jansen E. J. , Czabanowska K. , de Pagter A. P. J. , de Koeijer R. J. 
Published: February 2024

AbstractBackgroundThe European Union faces severe and worsening personnel shortages in healthcare. Coaching has emerged as a human‐centred strategy to enhance sustainable employment and retention. While the number of efficacy studies on coaching continues to grow, knowledge about the barriers and facilitators to implementing coaching interventions among healthcare professionals (HCPs) remains scarce.ObjectivesThis systematic review aimed to describe common barriers and facilitators to the implementation of coaching interventions for HCPs.MethodsIn April 2023, five databases were searched for eligible articles. Barriers and facilitators were systematically identified and mapped onto the constructs of the Consolidated Framework for Implementation Research (CFIR). Directed content analysis yielded thematic areas and a reporting frequency.ResultsA total of thirty (n = 30) studies were included in this review, representing twenty‐five (n = 25) distinct coaching programmes. Implementation determinants were clustered under two CFIR domains: the Inner Setting (8 facilitators, 5 barriers) and Implementation Process (6 facilitators, 1 barrier). Barriers included (i) limited organisational capacity, (ii) lack of psychological safety, (iii) competing work demands, and (iv) insufficient leadership buy‐in, while facilitators were the (i) allocation of protected time for participants and coaches, (ii) promotion through opinion leaders, (iii) embeddedness in existing Continuous Professional Development programmes, and (iv) programme co‐creation.ConclusionThe findings of this study provide practical insights to guide the future implementation of coaching interventions at an organisational level. In particular, the identified barriers and facilitators suggest, for optimal efficacy and sustainment, coaching interventions must be implemented within a safe, supportive organisational climate.
Sediment quality classification in freshwater lakes predicted by the history of treatment with copper-based aquatic algaecides
Authors: Chen Yu , Sullivan Patrick J. , Paul Eric 
Published: February 2024

Abstract
Copper-based aquatic algaecides have been widely used in the management of aquatic macrophyte and harmful algal blooms for decades due to their effectiveness and low cost. However, repeated treatment of freshwater lakes results in the accumulation of copper in the sediment, which may adversely affect the ecosystem of the lakes through toxicity to benthic invertebrates and other organisms. Consequently, copper-based aquatic herbicides and algaecides have been frequently subjected to regulations aimed at preventing further ecological deterioration in treated waterbodies. Many states in the US are taking or considering taking an approach that limits or prohibits copper treatment in waterbodies. Freshwater lakes with extensive historical copper treatments typically have significantly higher concentrations of copper in the sediment than untreated lakes. However, the correlation between the extent of the treatments and level of copper accumulation in the sediment has not been quantitatively characterized. In the present study, between 2006 and 2017, copper concentrations were measured in the sediment from selected lakes in New York State with different histories of copper-based aquatic algaecide treatment. Analysis of these data confirmed findings from earlier studies conducted by New York State that lakes with histories of copper treatment have significantly higher copper concentrations in the sediment. It also demonstrated that sediment copper concentrations were significantly higher in the sublittoral zone than the littoral zone in treated lakes. Moreover, a positive correlation was detected between sediment copper concentrations and the total number of treatments with copper-based aquatic algaecide for both littoral and sublittoral zones (p-value = 7.94 × 10−8 and 3.1 × 10−13, respectively). This relationship can be used as a screening tool for regulatory agencies to identify lakes with sediment copper levels possibly higher than the toxicity threshold for aquatic life. Consequently, additional ecological risk assessment may be required before allowing future treatment with copper-based aquatic algaecides. Integr Environ Assess Manag 2024;20:1586–1597. © 2024 SETAC
Key Points
Sediment copper concentration in freshwater lakes is positively correlated with the extent of copper-based algaecide treatment in the past. The correlation can be quantitatively characterized and used by regulators as a screening tool for management of future treatment of freshwater lakes with copper-based algaecide.
Retracted: International expansion and audit opinion shopping: A signaling perspective
Authors: Ding Hao 
Published: February 2024

AbstractOpinion shopping is an essential indication of audit collusion. Hence, it is crucial to explore the driving factors of audit uopinion shopping to better control and address this issue. Drawing upon signaling theory, this paper explores the relationship between international expansion and audit opinion shopping and the moderating roles of internal control quality and auditors’ quality. We find that the higher the level of international expansion of an enterprise, the greater the likelihood of audit opinion shopping. Furthermore, we also find that high internal control quality and high auditor quality can weaken the positive relationship between international expansion and audit opinion shopping. Besides, heterogeneity analysis shows that the impact of international expansion on audit opinion shopping is more pronounced in non‐SOEs and firms which stay in the growth and maturity stage. This paper contributes to the antecedent research of audit opinion shopping and exposes the possible “dark side” of international expansion. Finally, this study may provide practical implications to help the authorities better regulate internationalized enterprises as well as contribute to the healthy development of the auditing market.
Avoiding embarrassment online: Response to and inferences about chatbots when purchases activate self‐presentation concerns
Authors: Jin Jianna , Walker Jesse , Reczek Rebecca Walker 
Published: February 2024

AbstractWe explore how self‐presentation concerns and the desire to avoid embarrassment impact two distinct types of interactions consumers have with chatbots: interactions when a chatbot's identity is (1) not disclosed and therefore ambiguous or (2) disclosed. We propose that consumers feel less embarrassed with a chatbot than a human service agent in purchase contexts where self‐presentation concerns are active because consumers ascribe less mind to chatbots. Therefore, when a chat agent's identity is ambiguous, consumers with greater self‐presentation concerns are more likely to infer that an agent is human because this judgment allows consumers to proactively protect themselves from potential embarrassment in the event they are interacting with a human. We further show that when agent identity is clearly disclosed, consumers respond more positively to chatbots than human agents. However, this effect is contingent on the extent to which the chatbot is imbued with human characteristics: Anthropomorphizing chatbots leads consumers with higher self‐presentation concerns to ascribe more mind to even clearly identified chatbots, resulting in a more negative consumer response.
Instructional strategies and challenges for implementing teledentistry in dental hygiene curricula: A qualitative study
Authors: Spearin Tricia A. , Ayers Candace L. 
Published: February 2024

AbstractPurpose/ObjectivesResearch has documented the implementation of telecommunications and virtual technology use in health care disciplines to expand accessibility. Despite the current trend of digital innovations in healthcare systems, telehealth technology is not readily adopted in the dental hygiene profession yet. Currently, no standardized educational framework exists in dental hygiene curricula to prepare professionals with the technical skill set and professional knowledge necessary for telehealth applications. The aims and objectives of this research were (1) to investigate existing dental hygiene educators’ pedagogical frameworks for incorporating telehealth technology into dental hygiene curricula, (2) explore these educators’ instructional strategies for teaching telehealth technology, and (3) examine the theoretical implications and practical outcomes of teaching telehealth technology for professional development and transferrable work‐force ready skills.MethodsA nine‐item, open‐ended, semi‐structured interview guide was prepared and approved by the Institutional Review Board (IRB) in January 2023 to qualitatively investigate accredited entry‐level dental hygiene programs in the United States. Thematic interpretational analysis was conducted using NVivo software.ResultsA total of 54 of the 328 dental hygiene programs volunteered for participation. Thirteen full‐time and part‐time dental hygiene educators met inclusion criteria. The core salient themes identified included (a) curriculum mapping, (b) technology integration, (c) professional collaboration, and (d) supplemental skill set.ConclusionsThese findings provide guidance to dental hygiene programs for bridging the teledentistry knowledge gap in curriculum development. Incorporating telehealth applications into dental hygiene curricula prepares future dental hygienists with the specialized training needed to function as a member of contemporary health care teams addressing access to care.