bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimedia-based hormone therapy information program for patients with prostate cancer: the result of a randomized pilot study
Authors: Chien Ching-Hui , Liu Kuan-Lin , Chuang Cheng-Keng , Wu Chun-Te , Chang Ying-Hsu , Yu Kai-Jie 
Published: December 2023

AbstractFew studies have explored the feasibility and efficacy of a multimedia information intervention for patients with prostate cancer who are undergoing hormone therapy. Thus, the purpose of the study was to assess the feasibility, acceptability, and the preliminary results of a multimedia-based hormone therapy information program (HTIP) on positive thinking and quality of life (QOL; primary outcomes) as well as social support and self-efficacy (secondary outcomes) of patients with prostate cancer. Patients with prostate cancer who were receiving hormone therapy were recruited from hospitals. After completing the pre-test questionnaire, patients were randomly divided into the multimedia information group (MIG; n = 40) and the control group (CG; n = 40). Patients in the MIG received a multimedia-based HTIP once a week for 6 weeks. Data were collected at 8 and 12 weeks after the pre-test. Measurement variables included positive thinking, QOL, social support, self-efficacy, and satisfaction with the program. The recruitment rate and retention rate were calculated for assessment of feasibility. The study had a 96.3% retention rate, and patients in the MIG were satisfied with the program. Preliminary results showed that, compared with those in the CG, patients in the MIG tended to exhibit higher positive thinking, prostate cancer-specific QOL, and social support at 8 weeks and 12 weeks after pre-test; however, the effect did not reach a statistically significant level. A multimedia-based HTIP is considered feasible and acceptable in patients with prostate cancer who underwent hormone therapy. Further research with a larger sample size, patients with high homogeneity in early-stage disease and long-term follow-up is needed to assess the efficacy of the intervention program.Trial registration: ClinicalTrials.gov (NCT04693910); Registered 05/01/2021.
Effects of variable-temperature heat reservoirs on performance of irreversible Carnot refrigerator with heat recovery
Authors: Zhang Zhe , Su Huan , Dai Guoqiang , Li Xiaohua , Zeng Liping 
Published: December 2023

AbstractThe outlet temperature of the heat recovery reservoir is an important parameter in the design of refrigeration with heat recovery systems. In this paper the second law of thermodynamics has been applied to an irreversible Carnot refrigerator with heat recovery (CRHR) coupled to variable-temperature heat reservoirs. The refrigerating rate, input power, refrigeration coefficient, heat recovery coefficient, comprehensive coefficient of performance and exergy efficiency are chosen as the objective functions. The design rule chosen for this study is that the heat transfer area should be constrained. The mathematical expressions for assessing performance parameters with respect to area ratio, were derived for this study. These expressions are transcendental equations. The numerical solution method was employed to calculate the approximate solutions of the optimum performance parameters in a numerical example. The results indicate that the increase in the outlet temperature of heat recovery reservoir could lead to a rise in the maximum value of refrigerating rate and minimum value of input power; also it will lead to the decline in the maximum value of refrigeration coefficient, heat recovery coefficient, comprehensive coefficient and the exergy efficiency. When the ratio of heat recovery heat exchanger area to the summation of high temperature heat exchanger area and the heat recovery heat exchanger area is 1.0, the performance coefficients would attain their limit values and all of the condensing heat could be recycled. Our findings are helpful to the design and optimization to inform preparation of standard relating to the development of refrigerator with heat recovery.
Cattle manure application for 12 and 17 years enhanced depth distribution of soil organic carbon and X-ray computed tomography-derived pore characteristics
Authors: Sangotayo Anuoluwa Ojonoka , Chakraborty Poulamee , Xu Sutie , Kumar Sandeep , Kovacs Peter 
Published: December 2023

AbstractLong-term fertilizer application in row crops may influence soil pore characteristics, thereby impacting soil aggregation and structure. Therefore, understanding the influences on soil pore characteristics is useful for adopting suitable conservation practices. However, the impact of cattle manure and inorganic fertilizer application at varied rates on soil pore characteristics in the soil profile at a microscale level remains limited. This study quantifies the impacts of manure and inorganic fertilizer amendments under a corn (Zea mays L.)-soybean (Glycine max L.)-spring wheat (Triticum aestivum) rotation system on soil pore characteristics using the X-ray computed tomography (XCT). Treatments included: low manure (LM; 4.4 and 3.3 Mg ha−1), medium manure (MM; 27.4 and 18.7 Mg ha−1), high manure (HM; 54.8 and 37.4 Mg ha−1), medium fertilizer (MF; 136 kg N ha−1, 49 kg P2O5 ha−1, and 91.5 kg K2O ha−1), high fertilizer (HF; 204 kg N ha−1, 73.5 kg P2O5 ha−1, and 137.3 kg K2O ha−1), and control (CK), respectively, at Brookings (initiated in 2008) and Beresford (2003) in South Dakota. Four intact soil cores were collected from each treatment at 0–10, 10–20, 20–30, and 30–40 cm depths. Results showed that the HM treatment increased the SOC by 8–68% compared to the CK and MF at 0–20 cm at the study sites. Both HM and MM treatments increased the macroporosity and mesoporosity in 0–20 cm soil depths at both study sites. Treatment did not always improve soil pore characteristics below 20 cm soil depth. Additionally, a positive correlation was observed between the XCT-derived macroporosity, total number of macropores, and SOC for all the treatments. Therefore, this study encourages the adoption of the XCT technique in quantifying soil pore characteristics and suggests that long-term medium manure application enhances soil structure as compared to an equivalent inorganic fertilizer application.
Effects of multiple factors on particle size selectivity under artificial extreme rainfall events on simulated Gobi surface
Authors: Sun Liying , Dai Qingyuan , Feng Ziheng 
Published: December 2023

AbstractUnderstanding multiple-factor effects on particle size selectivity by extreme rainfall events in Ala-Shan Gobi desert is of great significance for better estimation of potential Asian dust emission sources. Artificial rainfall simulation experiments were used to investigate the particle size selectivity characteristics by extreme rainfall events under different rainfall intensities (20 mm h−1 and 40 mm h−1), slope gradients (3° and 15°) and gravel coverages (0, 30%, and 60%). Moreover, the relations of clay content (Clc), silt content (Sic), fine particle (< 50 μm) content (Fic) and enrichment ratio of fine particles (ER<50) with multiple factors were regressed and validated. Results show that rainfall intensity significantly (P < 0.05) affect runoff and sediment yield processes, but slope gradient was a dominant factor that changed particle size distribution (PSD). The selectivity of fine particles was higher at low rainfall intensity (20 mm h−1), gentle slope (3°) and moderate gravel coverage (30%), with ER<50 reaching 6.14, which dominate the potential Asian dust emission sources. The interaction were discussed and classified into ‘Synergy’ and ‘Trade-off’. Clc and Fic showed negative exponential relationship with rainfall intensity and slope gradient, but positive exponential relationship with gravel coverage. While Sic and ER<50 showed negative power function relationship with rainfall intensity, slope gradient and gravel coverage. These findings could help to understand the effects of multiple factors on potential sources of Asian dust emission under extreme rainfall events in Gobi region of northwestern China and provide basic science reference for the prediction of dust emission in this region.
Out-of-hospital cardiac arrest patients during the coronavirus disease 2019 pandemic
Authors: Watanabe Kenta , Mori Kosuke , Sato Kosuke , Abe Takeru , Imaki Shouhei , Takeuchi Ichiro 
Published: December 2023

AbstractThe coronavirus disease 2019 (COVID-19) pandemic had severe impact on the outcome of out-of-hospital cardiac arrest (OHCA) patients and the possibility of bystander cardiopulmonary resuscitation (CPR). Previous studies focused only on the short periods of the pandemic and reported a significant increase in the number of infections. In a retrospective cohort study we aimed to compare the outcomes of OHCA patients 1 year before and 1 year after the onset of COVID-19. Data of 519 OHCA patients during the pre-pandemic (January–December 2019; 262 patients) and intra-pandemic (April 2020–March 2021; 257 patients) periods in Yokohama Municipal Hospital, Japan were collected and analysed retrospectively. The study outcomes were the return of spontaneous circulation (ROSC), admission to hospital, survival to discharge, and cerebral performance category at discharge. The intra-pandemic period was associated with decreased bystander CPR (P = 0.004), prolonged transport time (P < 0.001), delayed first adrenaline administration (P < 0.001), and decrease in ROSC (P = 0.023). Logistic regression analysis revealed that the following factors were significantly associated with ROSC: “pandemic”, “shockable initial waveform”, and “witness presence”.
Multi-silicone bilateral soft physical twin as an alternative to traditional user interfaces for remote palpation: a comparative study
Authors: Costi Leone , Iida Fumiya 
Published: December 2023

AbstractTeleoperated medical technologies are a fundamental part of the healthcare system. From telemedicine to remote surgery, they allow remote diagnosis and treatment. However, the absence of any interface able to effectively reproduce the sense of touch and interaction with the patient prevents the implementation of teleoperated systems for primary care examinations, such as palpation. In this paper, we propose the first reported case of a soft robotic bilateral physical twin for remote palpation. By creating an entirely soft interface that can be used both to control the robot and receive feedback, the proposed device allows the user to achieve remote palpation by simply palpating the soft physical twin. This is achieved through a compact design showcasing 9 pneumatic chambers and exploiting multi-silicone casting to minimize cross-noise and allow teleoperation. A comparative study has been run against a traditional setup, and both the control and feedback of the physical twin are carefully analyzed. Despite distributed tactile feedback not achieving the same performance as the visual map, the soft control and visual feedback combination showcases a 5.1% higher accuracy. Moreover, the bilateral soft physical twin results always in a less invasive procedure, with 41% lower mechanical work exchanged with the remote phantom.
Sex-dimorphism in human serum endocannabinoid and n-acyl ethanolamine concentrations across the lifespan
Authors: Amir Hamzah Khalisa , Toms Leisa-Maree , Kucharski Nathaniel , Orr Julia , Turner Natalie P. , Hobson Peter , Nichols David S. , Ney Luke J. 
Published: December 2023

AbstractThe endocannabinoid (ECB) system has recently been considered a potential treatment target for various clinical disorders. However, research around age- and sex-related changes within the ECB system is relatively limited. To improve our understanding of these changes, the current study measured arachidonoyl ethanolamide (AEA), 2-arachidonoyl glycerol (2-AG), oleoylethanolamine (OEA), palmitoylethanolamine (PEA), arachidonic acid (AA), cortisol, and progesterone in pooled serum samples stratified by sex (male and female) and age groups (5–15; 15–30; 30–45; 45–60; 60–75; 85+), using liquid-chromatography tandem mass spectrometry. Serum progesterone levels significantly increased in females of the 15–30 and 30–45 age groups, before declining. Significantly higher cortisol, AEA, 2-AG, OEA, and PEA were found in males and in older age, while significantly higher AA was found in females. Our results indicate that ECBs and related hormones exhibit sexual dimorphism in the age ranges that correspond with female pregnancy, menopause, and post menopause. Male testosterone levels most likely influences male ECB changes throughout the lifespan. Future research could capitalise on these findings by performing repeated measurements in individuals in a longitudinal style, to further refine the temporal profile of age-specific changes to the ECB system identified here.
Modelling the upwelling radiance detected in a seawater column for oil-in-water emulsion tracking
Authors: Lednicka Barbara , Otremba Zbigniew , Piskozub Jacek 
Published: December 2023

AbstractThis study concerns changes in the solar light transfer in seawater as a result of the appearance of oil substances in the form of oil-in-water emulsions. The expected effect of the studies is to gather knowledge that would be useful in designing an optical sensor for monitoring oil substances penetrating the seawater column. The paper presents the process of the Monte Carlo modelling of the upwelling radiance detected by a virtual underwater sensor. Moreover, this article discusses the predicted difference between the intensity of the signal from the upwelling radiance meter and the signal from the downwelling radiance meter. The modelling results suggest that in order to obtain a strong signal indicating the presence of oil substances, the radiance meter should receive light running upwards in the sea depth.
Adaptive edge detection of rebar thread head image based on improved Canny operator
Authors: Liu Li , Liu Zijin , Hou Aishan , Qian Xuefei , Wang Hui 
Published: December 2023

AbstractThe quality of the rebar thread head is crucial for the connection between the rebars, thereby affecting the public safety of the building. The edge extraction of the thread image is the most important step in obtaining the accurate size parameters, which helps to complete online inspection of quality. Here, an edge detection method based on improved Canny operator is proposed to solve the problems on sensitivity to noise, existence of false edges, and lack of self‐adaptability. Firstly, an improved adaptive median filtering algorithm is used to denoise the image. Then replace Sobel with Scharr to enhance the gap between pixel values, add 45° and 135° directional templates to prevent edge information loss as well. Besides, introduce a scale factor to improve the interpolation method for non‐maximum suppression and reduce false edges. Finally, use Ostu operator to achieve adaptive extraction of high and low thresholds to complete adaptive edge detection. The qualitative analysis and quantitative results show that the improved algorithm can not only have a good visual effect, have good robustness and feasibility, but also be faster than other algorithms, which provide a basic guarantee for real‐time online quality detection of the thread head.
Thoracoscopic Stage Internal Traction Repair Reduces Time to Achieve Esophageal Continuity in Long Gap Esophageal Atresia
Authors: Borselle Dominika , Davidson Joseph , Loukogeorgakis Stavros , De Coppi Paolo , Patkowski Dariusz 
Published: December 2023

Objective Management of long gap esophageal atresia (LGOA) is controversial. This study aims at comparing the management of LGOA between two high-volume centers.
Methods We included patients with LGOA (type A and B) between 2008 and 2022. Demographics, surgical methods, and outcomes were collected and compared.
Results The study population involved 28 patients in center A and 24 patients in center B. A surgical approach was thoracoscopic in center A, only for one patient was open for final procedure. In center B, 3 patients were treated only thoracoscopically, 2 converted to open, and 19 as open surgery. In center A primary esophageal anastomosis concerned 1 case, two-staged esophageal lengthening using external traction 1 patient, and 26 were treated with the multistaged internal traction technique. In 24 patients a full anastomosis was achieved: in 23 patients only the internal traction technique was used, while 1 patient required open Collis–Nissen procedure as final management. In center B primary anastomosis was performed in 7 patients, delayed esophageal anastomosis in 8 patients, esophageal lengthening using external traction in 1 case, and 9 infants required esophageal replacement with gastric tube. Analyzed postoperative complications included: early mortality, 2/28 due to accompanied malformations (center A) and 0/24 (center B); anastomotic leakage, 4/26 (center A) treated conservatively—all patients had a contrast study—and 0/24 (center B), 1 case of pleural effusion, but no routine contrast study; recurrent strictures, 13/26 (center A) and 7/15 (center B); and need for fundoplication, 5/26 (center A) and 2/15 (center B). Age at esophageal continuity was as a median of 31 days in center A and 110 days in center B. Median time between initial procedure and esophageal anastomosis was 11 days in center A and 92 days in center B.
Conclusion Thoracoscopic internal traction technique reduces time to achieve esophageal continuity and the need for esophageal substitution while maintaining a similar early complication rate.
Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023
Authors: Schmoeckel Michael , Längin Matthias , Reichart Bruno , Abicht Jan-Michael , Bender Martin , Michel Sebastian , Kamla Christine-Elena , Denner Joachim , Tönjes Ralf Reinhard , Schwinzer Reinhard , Marckmann Georg , Wolf Eckhard , Brenner Paolo , Hagl Christian 
Published: December 2023

AbstractThis report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.
Synthesis of a Propellane-Type 5/5/6-Tricyclic System by Tandem-Metathesis: A New Approach to a Quadranoid Skeleton
Authors: Kotha Sambasivarao , Keesari Ramakrishna Reddy 
Published: December 2023

AbstractWe disclose a useful synthetic method for preparing the propellane-type 5/5/6-tricyclic system that is present in diquinane-based natural products such as quadrone, terrecyclic acid A, or terrecyclol. The method involves an LDA-mediated regio- and stereoselective allylation and a tandem metathesis as key steps. The target molecules were assembled in just two steps starting from a readily available building block, a 3β-vinyl tricyclic ketone prepared from endo-dicyclopentadiene-1-one. All the compounds prepared were characterized by NMR analyses and/or chemical methods. The synthetic methods demonstrated here are useful in syntheses of quadranoid-type natural products.
Regiocontrolled Halogen Dance and In Situ Transmetalation of Pyrroles Directed by the α-Substituent
Authors: Okano Kentaro , Matsuyama Daichi , Okumi Tatsuki , Mori Atsunori 
Published: December 2023

AbstractMultiply substituted pyrroles are found in medicines, natural products, and functional materials. A general method for introducing functionality on the pyrrole ring is thus required. Herein, a regiocontrolled halogen dance reaction and an in situ transmetalation of α-functionalized bromopyrroles are reported. Selective generation of the isomeric pyrrolylmetal species was achieved by using an ethyl ester or a phenyl group at the α-position of the pyrrole and by switching between the halogen dance reaction and in situ transmetalation. These reactions proceeded smoothly when an N,N-dimethylsulfamoyl group was attached to the pyrrole nitrogen atom, providing the corresponding products in 68% to quantitative yields on 1-mmol scale. This method was applicable to the formal synthesis of Kendine 91.
Clinical Outcomes of Crizotinib Readministration in Patients with Nonsmall Cell Lung Cancer with Anaplastic Lymphoma Kinase Rearrangement: Case Report and Review of Literature
Authors: Parida Prasant Kumar 
Published: December 2023

AbstractRecent studies have demonstrated promising outcomes of the first-line anaplastic lymphoma kinase-tyrosine kinase inhibitor (ALK-TKI) “crizotinib” in patients with locally advanced and metastatic lung cancers with high expression of the fusion protein “EML4-ALK.” High drug resistance, however, restricts the therapeutic advantages of ALK-TKIs in patients with nonsmall cell lung cancer (NSCLC). The contemporary literature documents limited treatment approaches for patients with NSCLC relapse or nonresponsiveness to second-/third-generation ALK-TKIs. We hereby provide a descriptive analysis of five NSCLC cases treated with crizotinib, ceritinib, and alectinib for a median duration of 54 months. The outcomes indicate a profound therapeutic response in patients receiving 4th and subsequent line of treatment with crizotinib. The crizotinib retreatment actively reduced patient resistance to the ALK-TKIs by reversing the mesenchymal epithelial transition amplification. The results from this case series also emphasize the possible role of next-generation sequencing in determining therapeutic resistance and transforming the treatment paradigm for NSCLC. Partial response was observed in the patients after 6 months of crizotinib readministration. This is possibly the first case series reporting crizotinib rechallenge in patients of ALK positive NSCLC who failed on subsequent ALK-TKIs and multiple lines of chemotherapies.
Management of Acute Hemorrhoidal Crisis: Evaluation, Treatment, and Special Considerations
Authors: Khan Ayman , Kanters Arielle E. 
Published: December 2023

AbstractHemorrhoidal disease is one of most common pathologies seen by colorectal and general surgeons. Although hemorrhoids themselves are a normal anatomic occurrence, development of symptomatic disease, usually due to bleeding, prolapse, or thrombosis, can cause significant patient distress. Acute presentation related to significant thrombosis or bleeding is referred to as acute hemorrhoidal crisis. Management of this pathology varies from nonoperative intervention for symptom control to definitive incisional or excisional hemorrhoidectomy. Here we will explore the approach to evaluating and treating acute hemorrhoidal crises.