bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, predictors, and mortality of Super-Fontan patients in a single-centre nationwide cohort
Authors: Illinger Vojtěch , Slabý Kryštof , Radvanský Jiří , Jičínská Denisa , Materna Ondřej 
Published: January 2025

AbstractAims:To evaluate the prevalence, long-term mortality, and clinical characteristics in total cavopulmonary connection patients with excellent functional outcomes.Methods and results:A retrospective study of cardiopulmonary exercise test results in 288 patients after total cavopulmonary connection from a single-centre nationwide database. A subgroup of 88 (30.6%) patients (45 women; 51.1%), at a median age 13.0 [interquartile range 11.0; 18.0] years achieved ≥80% of predicted VO2peak value (Super-Fontan phenotype). Survival free from death or heart transplantation 20 years after surgery was 100.0% in the Super-Fontan group versus 94.0% in the rest of the cohort (p = 0.04). Super-Fontan patients were younger, had lower body mass index, lower regurgitant fraction on atrioventricular valve, and larger preoperative McGoon ratio than the rest of the cohort (p = 0.002, p < 0.0001, p = 0.004, and p = 0.04, respectively). Females and tricuspid atresia patients were significantly more prevalent in the Super-Fontan group than in the rest of the cohort (p = 0.02 for both). There was no difference regarding systemic ventricle morphology, fenestration presence, or ejection fraction of systemic ventricle between the Super-Fontan group and the rest of the total cavopulmonary connection cohort (p = 0.06, p = 0.09, and p = 0.64, respectively).Conclusions:The subgroup of Super-Fontan patients has unique clinical characteristics when compared to the rest of the total cavopulmonary connection nationwide cohort. Besides superior VO2peak results, Super-Fontan patients tend to have lower long-term mortality, body mass index, and atrioventricular valve, greater preoperative pulmonary dimensions, and a higher prevalence of females and tricuspid atresia patients. There was no variance in morphology of the systemic ventricle, or presence of fenestration.
A 3-D printed X-band spherical waveguide filter based on the hybrid BSCT and CT topology
Authors: Zhang Sheng , Qiao Hongliang , Rao Jiayu , Wu Xilong , Zhao Enhui 
Published: January 2025

Abstract
In this paper, a novel dual-mode spherical resonator is proposed. By rotating the coupling irises, perturbations are generated to split the degenerate modes. The proposed filter is cascaded by a dual-mode resonator and two single-mode resonators, which are placed in a rotary way. Four poles appear in three resonators by only changing the rotation angle (φ) without any additional design. It forms the BSCT, generating a transmission zero (TZ) at the upper stopband. Furthermore, by adjusting φ further, the CT coupling topology can be obtained, resulting in a TZ at the lower stopband. Finally, slots are etched on the surface of the resonators for spurious response suppression. With the above methods, the out-of-band selectivity and suppression are greatly improved. For the fast validation, the filter is 3-D printed and measured. As a result, the measured results match well with the simulated ones.
Evolving Dunes Under Flow Reversals: From an Initial Heap Toward an Inverted Dune
Authors: Assis W. R. , Franklin E. M. , Vriend N. M. 
Published: January 2025

AbstractSand dunes are ubiquitous in nature, and are found in abundance on Earth and other planetary environments. One of the most common types are crescent‐shaped dunes known as barchans, whose mid‐line could be assumed to behave as 2D dunes. In this work, we (a) compare the morphology of the mid‐line of 3D barchans with 2D dunes; and (b) track the evolution of 3D barchans and 2D dunes while reversing flow conditions. We performed experiments on 2D dunes in a 2D flume and Euler‐Lagrange simulations of 3D bedforms. In all reversal experiments and simulations, the initial condition starts with a conical heap being deformed into a steady‐state dune, which is then perturbed by reversing the flow, resulting in an inverted dune. We show that during the reversal the grains on the lee side immediately climb back onto the dune while its internal part and toe remain static, forming a new lee face of varying angle on the previous stoss slope. We show that (a) the characteristic time for the development of 2D dunes scales with that for 3D barchans, (b) that the time for dune reversal is twice the time necessary to develop an initial triangular or conical heap to steady‐state, and (c) that a considerable part of grains remain static during the entire process. Our findings reveal the dynamics for dune reversal, and highlight that numerical computations of barchans based on 2D slices, which are more feasible in geophysical scales, predict realistic outcomes for the relevant time‐scales.
Application of SuperDARN Interferometry for Improved Estimates of Doppler Velocity and Echo Geolocation
Authors: Ponomarenko P. , Ghalamkarian Nejad M. , Koustov A. V. 
Published: January 2025

AbstractIt has been previously established that the Doppler velocities of F‐region ionospheric echoes observed by the Super Dual Auroral Radar Network (SuperDARN) at high frequencies (HF, 8–20 MHz) are persistently lower than those measured by other instruments at the same locations. This was attributed to the ionospheric refractive index for HF radio waves being noticeably smaller than one. The refractive index values can be obtained in two ways: based on electron density estimates from a co‐located instrument or a model, or by deriving them from SuperDARN elevation angle data. To compare these methods, we considered line‐of‐sight Doppler velocity observations by the Rankin Inlet (RKN) SuperDARN radar and the Resolute Bay Incoherent Scatter Radars (RISR). The velocity data were supplemented by electron density measurements from RISR. The elevation angle data were also used for accurate determination of SuperDARN echo geolocation because the actual ground range to the echo location may significantly differ from that obtained with the conventional SuperDARN models. The RISR Doppler velocity values were used as a reference to the RKN observations via 0.5‐hop and 1.5‐hop propagation paths. Correction by the index of refraction based on both maximum electron density from the RISR and elevation angle data from RKN brought 0.5‐hop data close to the RISR velocity values, with the latter representing a self‐contained approach. However, for 1.5‐hop echoes from the polar cap, the uncorrected SuperDARN velocities exceeded those from RISR. We discuss potential causes of this apparent anomaly.
Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway
Authors: Sun Teng , Li Jialei , Wang Shuang , Han Yu , Tao Xiangyu , Yuan Min , Jing Zhijie , Liu Ting , Qi Yuehong , Liu Siqi , Feng Yanlin , Chang Jiasong , Zhou Lan , Gao Lijuan , Shi Jianyun , Ning Ruihong , Cao Jimin 
Published: January 2025

Abstract
Programmed necrosis/necroptosis greatly contributes to the pathogenesis of cardiac disorders including myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure. However, the fundamental mechanism underlying myocardial necroptosis, especially the mitochondria-dependent death pathway, is poorly understood. Synaptotagmin-1 (Syt1), a Ca2+ sensor, is originally identified in nervous system and mediates synchronous neurotransmitter release. The later findings of Syt1 expressions in many non-neuronal tissues including muscles suggest that Syt1 may exert important functions beyond regulation of neurotransmitter release. Syt1 is highly expressed in cardiomyocytes and has been used as an extracellular molecular probe for SPECT imaging of cardiac cell death in acute myocardial infarction. However, whether Syt1 functions in the pathogenesis of cardiac disorders and what is the molecular etiology have not yet been clarified. We showed here that Syt1 expression was significantly down-regulated in mice I/R injured heart tissues, H2O2-challenged cardiomyocytes and hypoxia/reoxygenation (H/R)-damaged cardiomyocytes. Enforced expression of Syt1 significantly inhibited myocardial necrotic cell death and interstitial fibrosis, and improved cardiac function in mice subjected to I/R operation. In exploring the underlying mechanisms, we found that Syt1 interacted with Parkin and promoted Parkin-catalyzed CypD ubiquitination, thus inhibited mitochondrial membrane permeability transition pore (mPTP) opening and ultimately suppressed cardiomyocyte necrosis. We further found that Syt1 expression was negatively regulated by miR-193b-3p. MiR-193b-3p regulated cardiomyocyte necrosis and mPTP opening by targeting Syt1. Our present work revealed a novel regulatory model of myocardial necrosis composed of miR-193b-3p, Syt1, Parkin, and CypD, which may provide potential therapeutic targets and strategies for heart protection.
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
Authors: Yanushko Darya , German Falcon Beatriz , El Bizri Rana , Pervizou Despoina , Dolgos Robin , Keime Céline , Ye Tao , Thibault-Carpentier Christelle , Le Magnen Clementine , Henri Sandrine , Laverny Gilles , Metzger Daniel 
Published: January 2025

Abstract
Prostate cancer is a heterogeneous disease with a slow progression and a highly variable clinical outcome. The tumor suppressor genes PTEN and TP53 are frequently mutated in prostate cancer and are predictive of early metastatic dissemination and unfavorable patient outcomes. The progression of solid tumors to metastasis is often associated with increased cell plasticity, but the complex events underlying TP53-loss-induced disease aggressiveness remain incompletely understood. Using genetically engineered mice, we show that Trp53 deficiency in Pten-null prostatic epithelial cells (PECs) does not impact early cell proliferation and neoplasia formation, nor growth arrest and senescence entry at a later time. However, Trp53-deficiency enhances invasive adenocarcinoma development and promotes metastatic cell dissemination. Importantly, our single-cell transcriptomic and chromatin accessibility analyses combined with histological examinations uncovered an epithelial cell population characterized by an induction of Jak/Stat3 signaling and displaying mesenchymal features. Moreover, we show that the transcriptomic signature of this cell population is prominent in tumors of patients with high-risk prostate cancer or metastatic disease. In addition, our in vivo and organoid-based experiments provide evidence that PEC plasticity occurs through bi-directional communication with cancer-associated fibroblasts (CAFs). Thus, our study demonstrates that p53 loss induces a protumorigenic crosstalk between PECs and CAFs, and identifies new vulnerabilities that might be targeted to limit cancer progression.
SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model
Authors: Zou Xiaodong , Wu Tong , Lin Jianjiao , Su Tao , Xiao Hui , Ni Chuyan , Hu Lijuan , Lin Wenchu , Chen Weilin , Ye Richard D. , Xiang Li 
Published: January 2025

Abstract
Intestinal fibrosis, as a late-stage complication of inflammatory bowel disease (IBD), leads to bowel obstruction and requires surgical intervention, significantly lowering the quality of life of affected patients. SAA3, a highly conserved member of the serum amyloid A (SAA) apolipoprotein family in mice, is synthesized primarily as an acute phase reactant in response to infection, inflammation and trauma. An increasing number of evidence suggests that SAA3 exerts a vital role in the fibrotic process, even though the underlying mechanisms are not yet fully comprehended. This study utilized dextran sulfate sodium (DSS) to establish an IBD mouse model and observed that the SAA3-deficient mice exhibited more severe intestinal fibrosis. Our results further indicated that SAA3 genetic disruption in fibroblasts enhanced cell activation to myofibroblasts through HSPB1/NF-κB/TGF-β1/Smads signaling cascade, exacerbating the pathological phenotype of intestinal fibrosis. Collectively, our results shed novel lights on regulating SAA3 in intestinal fibrosis and indicate the potential to develop therapeutic strategies for IBD patients.
Tubulin tyrosination/detyrosination regulate the affinity and sorting of intraflagellar transport trains on axonemal microtubule doublets
Authors: Chhatre Aditya , Stepanek Ludek , Nievergelt Adrian Pascal , Alvarez Viar Gonzalo , Diez Stefan , Pigino Gaia 
Published: January 2025

Abstract
Cilia assembly and function rely on the bidirectional transport of components between the cell body and ciliary tip via Intraflagellar Transport (IFT) trains. Anterograde and retrograde IFT trains travel along the B- and A-tubules of microtubule doublets, respectively, ensuring smooth traffic flow. However, the mechanism underlying this segregation remains unclear. Here, we test whether tubulin detyrosination (enriched on B-tubules) and tyrosination (enriched on A-tubules) have a role in IFT logistics. We report that knockout of tubulin detyrosinase VashL in Chlamydomonas reinhardtii causes frequent IFT train stoppages and impaired ciliary growth. By reconstituting IFT train motility on de-membranated axonemes and synthetic microtubules, we show that anterograde and retrograde trains preferentially associate with detyrosinated and tyrosinated microtubules, respectively. We propose that tubulin tyrosination/detyrosination is crucial for spatial segregation and collision-free IFT train motion, highlighting the significance of the tubulin code in ciliary transport.
Highly efficient construction of monkey blastoid capsules from aged somatic cells
Authors: Wu Junmo , Shao Tianao , Tang Zengli , Liu Gaojing , Li Zhuoyao , Shi Yuxi , Kang Yu , Zuo Jiawei , Zhao Bo , Hu Guangyu , Liu Jiaqi , Ji Weizhi , Zhang Lei , Niu Yuyu 
Published: January 2025

Abstract
Blastoids—blastocyst-like structures created in vitro—emerge as a valuable model for early embryonic development research. Non-human primates stem cell-derived blastoids are an ethically viable alternative to human counterparts, yet the low formation efficiency of monkey blastoid cavities, typically below 30%, has limited their utility. Prior research has predominantly utilized embryonic stem cells. In this work, we demonstrate the efficient generation of blastoids from induced pluripotent stem cells and somatic cell nuclear transfer embryonic stem cells derived from aged monkeys, achieving an 80% formation efficiency. We also introduce a hydrogel-based microfluidics platform for the scalable and reproducible production of size-adjustable, biodegradable blastoid capsules, providing a stable 3D structure and mechanical protection. This advancement in the high-efficiency, scalable production of monkey blastoid capsules from reprogrammed aged somatic cells significantly enhances the study of embryonic development and holds promise for regenerative medicine.
The global Multidimensional Poverty Index: Harmonised level estimates and their changes over time
Authors: Suppa Nicolai , Kanagaratnam Usha 
Published: January 2025

Abstract
This paper describes the database The global Multidimensional Poverty Index (MPI): Harmonised level estimates and their changes over time. The global MPI is an international poverty measure based on ten deprivation indicators in three dimensions: health, education, and living standards. The database contains estimates for the MPI itself (the adjusted headcount ratio); related partial indices such as headcount ratio, intensity, indicator-specific indices, and several auxiliary statistics; and changes over time for most quantities. For this database, all deprivation indicators have been harmonised over time. Our database covers estimates for 84 countries and 814 subnational regions for up to four points of observation. The estimates are based on 211 individual survey datasets, provided primarily by the Demographic Health Surveys (DHS) and the Multiple Indicator Cluster Surveys (MICS). Combining information about different dimensions of human wellbeing, the global MPI inherently invites interdisciplinary research.
Influence of elevated temperature exposure on the residual compressive strength and radiation shielding efficiency of ordinary concrete incorporating granodiorite and ceramic powders
Authors: Mahmoud Alaa A. , El-Sayed Alaa A. , Aboraya Ayman M. , Fathy Islam N. , Abouelnour Mohamed A. , Elfakharany Maged E. , Fattouh Mohy S. , Alahmer Abdelmoniem E. , Nabil Islam M. 
Published: January 2025

Abstract
This research investigates the potential of utilizing types of construction waste as partial cement replacements within concrete formulations. Notably, granodiorite and ceramic powders were introduced at varying substitution ratios. The impact of these waste materials on the compressive strength and radiation shielding effectiveness of traditional concrete was evaluated under both ambient and elevated temperature conditions. Additionally, several microstructural tests like X-ray diffraction (XRD), Thermogravimetric analysis (TGA), and Energy dispersive X-ray (EDX) were conducted to assess the influence of using the optimal replacement ratios of the investigated waste powders on the studied properties of concrete. Results revealed a substantial improvement in the investigated properties of the concrete. Remarkably, a 7% substitution with waste granodiorite powder (WGDP) yielded the optimal mix for compressive strength, exhibiting increases of 24.7%, 26.1%, 22%, and 28% at room temperature, 400 °C, 600 °C, and 800 °C, respectively. Likewise, a 7% replacement with waste ceramic powder (WCP) exhibited quantifiable improvements in compressive strength, with approximately 23.1%, 23.5%, 25.6%, and 32.6% at room temperature, 400 °C, 600 °C, and 800 °C, respectively. For microstructure analysis, XRD analysis confirmed enhanced pozzolanic activity with reduced portlandite and increased calcium silicate hydrate (CSH) formation for the optimal WGDP and WCP mixes compared to the control mix. TGA analysis revealed higher CSH decomposition in modified mixes, indicating greater pozzolanic reaction. Furthermore, density and EDX analyses showed denser microstructures in waste powders-incorporated mixes due to finer particle packing and secondary hydration effect. The radiation shielding investigation show that the optimum WCP mix (C7) enhances the attenuation capability of concrete. The optimum WGP mix (GD7) also contributes positively to attenuation, though to a lesser extent than C7. Ordinary concrete (CO) exhibits the lowest
$$\it \:\text{C}\text{M}$$

LAC, indicating its baseline performance in linear attenuation. Thus, the studied CM-concrete samples provide the best protection against fast neutrons which pave the way for the utilization of industrial waste, especially ceramic and granodiorite waste, in enhancing the properties of concrete towards radiation shielding against gamma rays and neutrons.
Digital transformation project risks assessment using hybrid picture fuzzy distance measure-based additive ratio assessment method
Authors: Rani Pratibha , Mishra Arunodaya Raj , Alrasheedi Adel Fahad , Pamucar Dragan , Marinkovic Dragan 
Published: January 2025

Abstract
Digital transformation (DT) has become vital for companies trying to remain competitive in the recent ever-changing technological environment. DT is the integration of digital technologies into all disciplines of business from regular activities to strategic decision making. Risk management planning requires projects to assess possible risks that may negatively or positively affect a DT project. The purpose of the study is to introduce a hybridized decision support system (DSS) by combining the distance measure, ranking comparison (RANCOM) model and additive ratio assessment (ARAS) approach in the context of a picture fuzzy set (PFS). In this framework, the decision experts’ significance values are computed using a picture fuzzy score function-based formula. With the combination of objective weight using distance measure and subjective weight through the RANCOM model, a combined weight-determining approach is developed to determine the significance values of considered DT risks under picture fuzzy environment, while a hybrid ARAS model is developed to evaluate and rank DT projects from the risks perspective. To exhibit the feasibility of the introduced framework, a case study of a DT projects assessment problem is discussed in the context of picture fuzzy sets. A sensitivity study is also discussed over different values of the strategy coefficient, which confirms the strength of the proposed model. Further, a comparison with the existing picture fuzzy information-based methods is presented to prove the robustness of the developed decision-making framework.
Utilizing hydrophobic sand to construct an air permeable aquiclude to enhance rice yields
Authors: Wu Jing , Ma Xiaoyan , Su Yuming , Qin Shengyi , Pilla Francesco 
Published: January 2025

Abstract
The Chinese government attaches great importance to the ecological restoration of abandoned open-pit mines, increasing the area of cultivated land, and ensuring food security. Soil reconstruction is a crucial step in ecological restoration of abandoned open-pit mines. This study investigated the utilization of hydrophobic sand to create an Air-Permeable Aquiclude (APAC) under the plant root zones, thereby minimizing water infiltration and enhancing soil aeration. Field plot experiments for 2 years have been conducted, with control groups, Clay Aquitard (CAT), and Plastic Aquiclude (PAC), to evaluate the effects of APAC on rice yield, nitrogen utilization, and water efficiency. The findings revealed that utilizing APAC resulted in a significant rise in rice yield, ranging from 8.09 t/hm² to 9.27 t/hm², which were 7.67–27.16% higher than the control groups. Moreover, the APAC led to a remarkable reduction in irrigation water usage by 37.08%, alongside a substantial boost in Irrigation Water Productivity (IWP) efficiency by 28.64–71.12%. Notably, Nitrogen Partial Factor Productivity (NPFP) exhibited a substantial increase of 7.69–27.06%. These outcomes underscore the APAC’s positive role in water and nutrient conservation and enhanced yields.
A cross sectional investigation of the development of rhythmic preferences with motor and perceptual tests
Authors: Rioux Pier-Alexandre , Grondin Simon 
Published: January 2025

Abstract
The preferred period hypothesis posits a slowing down of motor and perceptual rhythmic preferences with age, both reflecting an increase in the common internal oscillation period. This study further investigates the preferred period hypothesis by improving the measurement of perceptual rhythmic preferences through two tasks, tempo adjustment and tempo judgment, conducted in auditory and visual modalities. The study was conducted with three groups of children (5–6, 8–9, and 11–12 years old), and a group of young adults (21 to 30 years old) during the same time of the day. Correlational analyses show that the relationship between motor and perceptual rhythmic preferences strengthens between childhood and adulthood. Multilevel analyses reveal a general slowing down of motor and perceptual rhythmic preferences, contingent on the task and modality, with distinct trajectories for males and females. Our study indicate that the range of preferred rhythms narrows with age, becoming less variable in young adulthood, at the expense of a single and consistent, default rhythm. In brief, the preferred period appears only in young adults, with no support for the idea of a slowing down of an internal oscillation that would be reflected by both motor and perceptual rhythmic preferences.