bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-method analysis of a historic wooden trough from Kentucky, USA: a case study in corroborating artifact oral histories with heritage science
Authors: Napora Katharine G. , Crothers George M. , Hadden Carla S. , Guerre Lisa , Waldman Laura J. , Reyes-Centeno Hugo , Keppeler James , Imler Madeline , Jakaitis Edward , Metz Alexander , Mink Philip B. 
Published: November 2023

Abstract
Oral history indicates that a large wooden trough held in storage at the University of Kentucky’s William S. Webb Museum of Anthropology was a component of the saltpeter mining operation in Mammoth Cave in the late 18th and early 19th centuries, worked largely by enslaved persons. We used multiple heritage science methods, including radiocarbon wiggle-match dating, tree-ring dating, scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM–EDS), and optical scanning, combined with historical research, to examine the trough. Our analysis supports the oral history of the trough as an artifact of the mining system in Mammoth Cave. This case study illustrates how heritage science methods can provide corroboration for the origins and biographies of poorly documented historical artifacts.
Designs and practices using generative AI for sustainable student discourse and knowledge creation
Authors: Lee Alwyn Vwen Yen , Tan Seng Chee , Teo Chew Lee 
Published: November 2023

AbstractUtilizing generative artificial intelligence, especially the more popularly used Generative Pre-trained Transformer (GPT) architecture, has made it possible to employ AI in ways that were previously not possible with conventional assessment and evaluation technologies for learning. As educational use cases and academic studies become increasingly prevalent, it is critical for education stakeholders to discuss design considerations and ideals that are key in supporting and augmenting learning via quality classroom discourse that sets the climate for student learning and thinking, and teachers’ transmission of expectations. In this paper, we seek to address how emergent technological advancements such as GPT, can be considered and utilized in designs that are consistent with the ideals of sustainable student discourse and knowledge creation. We showcase contemporary exemplars of possible designs and practices that are based on the pedagogy of knowledge building, with recent illustrations of how GPT may be utilized to sustain students’ knowledge building discourse. We also examine the potential effects and repercussions of technological utilization and misuse, along with insights into GPT’s role in supporting and enhancing knowledge building practices. We anticipate that the findings, through our exploration of designs and practices for knowledge creation, will be able to resonate with a broader audience and instigate meaningful change on issues of teaching and learning within smart learning environments.
Effects of Specific Bioactive Collagen Peptides in Combination with Concurrent Training on Running Performance and Indicators of Endurance Capacity in Men: A Randomized Controlled Trial
Authors: Jerger Simon , Jendricke Patrick , Centner Christoph , Bischof Kevin , Kohl Jan , Keller Simon , Gollhofer Albert , König Daniel 
Published: November 2023

Abstract
Background
First evidence indicates that the supplementation of specific collagen peptides (SCP) is associated with a significant improvement in running performance in physically active women; however, it is unclear if the same is true in males. The purpose of the present study was to investigate the effects of a concurrent training program including 60 min of continuous moderate intensity running training and 15 min of dynamic resistance training combined with supplementation of SCP on parameters of running performance in moderately trained males.

Methods
In a double-blind, placebo-controlled, randomized trial, participants performed a 12 weeks concurrent training and ingested 15 g of SCP [treatment group (TG)] or placebo [control group (CG)] daily. Before and after the intervention, running endurance performance was measured by a 1-h time trial on a running track. Velocity at the lactate threshold (VLT) and at the individual anaerobic threshold (VIAT) were assessed on a treadmill ergometer. Body composition was evaluated by bioelectrical impedance analysis.

Results
Thirty-two men (28.4 ± 5.2 years) completed the study and were included in the analysis. After 12 weeks, TG had a statistically significant (p ≤ 0.05) higher increase in running distance (1727 ± 705 m) compared to the CG (1018 ± 976 m) in the time trial. VLT increased in the TG by 0.680 ± 1.27 km h−1 and slightly decreased by − 0.135 ± 0.978 km h−1 in the CG, resulting in statistically significant group differences (p ≤ 0.05). A significantly higher improvement in VIAT (p ≤ 0.05) was shown in the TG compared with the CG only (1.660 ± 1.022 km h−1 vs 0.606 ± 0.974 km h−1; p ≤ 0.01). Fat mass decreased (TG − 1.7 ± 1.6 kg; CG − 1.2 ± 2.0 kg) and fat free mass increased (TG 0.2 ± 1.2 kg; CG 0.5 ± 1.3 kg) in both groups with no significant group differences.

Conclusion
In summary, supplementation with 15 g of SCP improved running performance in a 1-h time trial and enhanced indicators of endurance capacity at submaximal exercise intensities such as an increased velocity at the lactate as well as the anaerobic threshold more effectively than CT alone.
Trial registration: ETK: 123/17; DRKS-ID: DRKS00015529 (Registered 07 November 2018—Retrospectively registered); https://drks.de/search/de/trial/DRKS00015529
A global systematic overview of socioeconomic factors associated with antidiabetic medication adherence in individuals with type 2 diabetes
Authors: Studer Christian Ming , Linder Marie , Pazzagli Laura 
Published: November 2023

AbstractBackgroundAntidiabetic medication adherence is a key aspect for successful control of type 2 diabetes mellitus (T2DM). This systematic review aims to provide an overview of the associations between socioeconomic factors and antidiabetic medication adherence in individuals with T2DM.MethodsA study protocol was established using the PRISMA checklist. A primary literature search was conducted during March 2022, searching PubMed, Embase, Web of Science, as well as WorldCat and the Bielefeld Academic Search Engine. Studies were included if published between 1990 and 2022 and included individuals with T2DM. During primary screening, one reviewer screened titles and abstracts for eligibility, while in the secondary screening, two reviewers worked independently to extract the relevant data from the full-text articles.ResultsA total of 15,128 studies were found in the primary search, and 102 were finally included in the review. Most studies found were cross-sectional (72) and many investigated multiple socioeconomic factors. Four subcategories of socioeconomic factors were identified: economic (70), social (74), ethnical/racial (19) and geographical (18). The majority of studies found an association with antidiabetic medication adherence for two specific factors, namely individuals’ insurance status (10) and ethnicity or race (18). Other important factors were income and education.ConclusionsA large heterogeneity between studies was observed, with many studies relying on subjective data from interviewed individuals with a potential for recall bias. Several socioeconomic groups influencing medication adherence were identified, suggesting potential areas of intervention for the improvement of diabetes treatment adherence and individuals’ long-term well-being.
Effect of some irrigation systems on water stress levels of Washington navel orange trees
Authors: Youssef Ebtessam A. , Mahmoud Tarek A. , Abo-Eid Manal A. M. 
Published: November 2023

Abstract
Background
This experimental study was conducted during two successive seasons 2021–2022 on 10-year-old Washington navel orange trees (Citrus sinensis) budded on sour orange rootstock (Citrus aurantium) under sandy loamy soil conditions in Belbeis district, Sharkia Governorate, Egypt. This experimental study was conducted to compare some irrigation systems with different water stress levels on Washington navel trees and to determine the best system in terms of irrigation water use efficiency using different irrigation systems (drip and micro-sprinklers) under different levels of water supply (100, 80, and 60% of ETc, i.e., the estimated water requirements of crops).

Results
The included data demonstrated that irrigation water amounts can be reduced by 20% for Washington navel trees, while maintaining production, with the possibility of increasing by using micro-sprinkler irrigation systems. In summary, water use efficiency increased with micro-sprinkler irrigation systems under ETc 80%, which resulted in 2.57 and 2.67 kg of fruit per cubic meter of irrigation water in the first and second seasons, respectively.

Conclusion
The results of the present study showed that using ETc 80% combined with micro-sprinklers irrigation system had a high economic return through increasing total yield, water use efficiency, and water unit return (WUR) which reached to 10.26 EGP/one cubic meter of irrigation water and using less water irrigation amount by 20% at the same time. Thus, we recommend applying the treatment of ETc 80% combined with micro-sprinklers irrigation system to Washington navel orange trees budded on sour orange rootstock to gain a high economic return.
Short-term recovery of post-fire vegetation is primarily limited by drought in Mediterranean forest ecosystems
Authors: Blanco-Rodríguez Miguel Ángel , Ameztegui Aitor , Gelabert Pere , Rodrigues Marcos , Coll Lluís 
Published: November 2023

Abstract
Background
Climate change is altering the fire regime and compromising the post-fire recovery of vegetation worldwide. To understand the factors influencing post-fire vegetation cover restoration, we calculated the recovery of vegetation in 200,000 hectares of western Mediterranean forest burned by 268 wildfires over a 27-year period (1988–2015). We used time series of the Tasseled Cap Transformation Brightness (TCTB) spectral transformation over Landsat imagery to calculate vegetation recovery. Then, we quantified the importance of the main drivers of post-fire vegetation recovery (climate, fire severity, and topography) along an aridity gradient (semi-arid, sub-humid, and humid) using Random Forest models.

Results
In most models (99.7%), drought duration was the most important factor, negatively affecting post-fire recovery especially in the extremes of the aridity gradient. Fire severity was the second most important factor for vegetation cover recovery, with its effect varying along the aridity gradient: there was a positive relationship between fire severity and recovery in sub-humid and humid areas, while semi-arid areas showed the opposite pattern. Topographic variables were the least important driver and had a marginal effect on post-fire recovery. Additionally, semi-arid areas exhibited a low mean recovery rate, indicating limitations in the short-term recovery after a fire.

Conclusions
Our study highlights the key role that drought duration plays in the recovery of vegetation after wildfires in the Mediterranean basin and, particularly, in forests located in climatically extreme areas. The results suggest that the predicted increase in drought duration coupled with a higher frequency and intensity of large fires may modify the structure and composition of Mediterranean forest ecosystems. Our analysis provides relevant information to evaluate and design adaptive management strategies in post-fire recovery hotspots of Mediterranean forest ecosystems.
Imaging changes of oil aspiration over time in children: a case series
Authors: Rashed Masoud Mahdavi , Hosseini Mojtaba Haji , Beizae Behnam , Alamdaran Seyed Ali , Alizadeh Anahita , Seyedi Seyed Javad , Hassannejad Ehsan , Tavakolizadeh Nahid 
Published: November 2023

Abstract
Background
Oil aspiration pneumonia is an uncommon form of lung disease due to aspiration or inhalation of oil-containing products. The present study reports the changes process of radiological findings over time in four children.

Case presentation
For 2 years, four cases (17 months until 3.5 years) with aspiration oil-containing (petroleum or benzene) products were referred to a tertiary center, Akbar Children’s Hospital, Mashhad Medical University of Science. They presented with respiratory distress and fever. The radiography, low-dose CT scan, and ultrasound findings were evaluated. Assessment of serial imaging findings in our patients shows decreased volume, ground glass opacity, and septal thickening in the lower lobes of the lungs are a predominant pattern in the first and second days. Consolidation and nodular opacity appear after 48 h. In the second week, the nodular pattern (fluid-filled pneumatoceles) is the main pattern and persists for 1 month. CT scan images showed that opaque nodules are actually fluid-filled pneumatoceles. Finally, air-filled pneumatoceles gradually appeared from the third week and disappeared in 6–8 months.

Conclusion
Our results show that four radiological phases of oil pneumonia, including ground glass opacities, segmental consolidation, fluid-filled pneumatoceles (nodule), and finally air-filled pneumatoceles, could be seen in radiography, CT scan, and ultrasound.
Nutritional support and prevention of post-intensive care syndrome: the Italian SIAARTI survey
Authors: Cotoia Antonella , Umbrello Michele , Ferrari Fiorenza , Pota Vincenzo , Alessandri Francesco , Cortegiani Andrea , De Rosa Silvia 
Published: November 2023

Abstract
Background
Malnutrition and muscle wasting are common in ICU patients and predict adverse patient-centered outcomes. The Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care (SIAARTI) conducted a nationwide survey to identify the nutritional practices in the Italian ICUs and to plan future, training interventions to improve the national clinical practice.

Methods
Nationwide online survey, involving Italian ICUs, developed by experts affiliated with SIAARTI. Invitations to participate were distributed through emails and social networks. Data were collected over a period of three months (October 1 to December 31, 2022) during 2022.

Results
One hundred full responses from participating ICUs were collected. The number of beds is < 10 in most ICUs and > 20 in 11 ICUs. Most ICUs (87%) are mixed, cardiac (5%), neurosurgical (4%), or pediatric ICUs (1%). Although the nutritional program is widely prescribed based on the patients’ general evaluation, 52 ICUs (52%) do not perform nutritional risk evaluation at admission in case of > 24-h stay. Daily caloric intake is mainly based on the 25 kcal/kg equation; otherwise, the Harris-Benedict formula is mostly used, whereas indirect calorimetry is less used. Most clinicians apply a personalized nutritional approach to organ failure. Most ICUs have a nutritional management protocol, and enteral nutrition (EN) is frequently started within 2 days from admission, while supplemental parenteral nutrition is used when EN is insufficient by most clinicians. The EN administered seems to correspond to that prescribed, but it is stopped if the gastric residual gastric is > 300–500 ml in most ICUs.

Conclusion
Prescription, route, and mode of administration of nutritional support seem to be in line with international recommendations, while suggestions on the tools for assessing the nutritional risk and monitoring efficacy and complications seem far less followed. Future national clinical studies are necessary to investigate the optimal nutritional and metabolic management of critically ill patients and the correspondence with the results of this survey on actual practices.
Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
Authors: Friedman Henry S. , Prados Michael D. , Wen Patrick Y. , Mikkelsen Tom , Schiff David , Abrey Lauren E. , Yung W.K. Alfred , Paleologos Nina , Nicholas Martin K. , Jensen Randy , Vredenburgh James , Huang Jane , Zheng Maoxia , Cloughesy Timothy 
Published: November 2023

PURPOSE We evaluated the efficacy of bevacizumab, alone and in combination with irinotecan, in patients with recurrent glioblastoma in a phase II, multicenter, open-label, noncomparative trial. PATIENTS AND METHODS One hundred sixty-seven patients were randomly assigned to receive bevacizumab 10 mg/kg alone or in combination with irinotecan 340 mg/m2 or 125 mg/m2 (with or without concomitant enzyme-inducing antiepileptic drugs, respectively) once every 2 weeks. Primary end points were 6-month progression-free survival and objective response rate, as determined by independent radiology review. Secondary end points included safety and overall survival. RESULTS In the bevacizumab-alone and the bevacizumab-plus-irinotecan groups, estimated 6-month progression-free survival rates were 42.6% and 50.3%, respectively; objective response rates were 28.2% and 37.8%, respectively; and median overall survival times were 9.2 months and 8.7 months, respectively. There was a trend for patients who were taking corticosteroids at baseline to take stable or decreasing doses over time. Of the patients treated with bevacizumab alone or bevacizumab plus irinotecan, 46.4% and 65.8%, respectively, experienced grade ≥ 3 adverse events, the most common of which were hypertension (8.3%) and convulsion (6.0%) in the bevacizumab-alone group and convulsion (13.9%), neutropenia (8.9%), and fatigue (8.9%) in the bevacizumab-plus-irinotecan group. Intracranial hemorrhage was noted in two patients (2.4%) in the bevacizumab-alone group (grade 1) and in three patients (3.8%) patients in the bevacizumab-plus-irinotecan group (grades 1, 2, and 4, respectively). CONCLUSION Bevacizumab, alone or in combination with irinotecan, was well tolerated and active in recurrent glioblastoma.
Current Recommended Estrogen Dosing for Pubertal Induction in Turner Syndrome Results in Normal Uterine Growth
Authors: Lindsay Mart Faith , Gutmark-Little Iris , Streich-Tilles Tara , Trout Andrew T , Khoury Jane , Bowers Katherine , Casnellie Lori , Backeljauw Philippe 
Published: November 2023

Abstract

Context
Most individuals with Turner syndrome (TS) require estrogen for pubertal induction. Current estrogen dosing guidelines are based on expert consensus opinion.

Objective
Evaluate whether current international guidelines for estrogen dosing during pubertal induction of individuals with TS result in normal uterine growth. We hypothesized that uterine size in individuals with TS who reached adult estrogen dosing is smaller than in mature females without TS.

Methods
Cross-sectional study of patients with TS at the Cincinnati Center for Pediatric and Adult Turner Syndrome Care. Twenty-nine individuals (age 15-26 years) with primary ovarian insufficiency who reached adult estrogen dosing (100 µg of transdermal or 2 mg of oral 17β-estradiol) were included. Comparison of uterine measurements with a published sample of 292 age-appropriate (age 15-20 years) controls without TS. Uterine length, volume, and fundal–cervical ratio (FCR) were measured. Clinical information (karyotype, Tanner staging for breast development, laboratory data) was extracted from an existing institutional patient registry.

Results
There was no evidence of compromise of the uterine size/configuration in the TS cohort compared with the controls; in fact, uterine length, mean 7.7 cm (±1.3) vs 7.2 cm (±1.0) (P = .03), and volume, mean 60.6 cm3 (±26.6) vs 50.5 cm3 (±20.5) (P = .02), were both larger in individuals with TS.

Conclusion
Current international guidelines for hormone replacement using 17β-estradiol in individuals with TS appear adequate to allow for normal uterine growth by the end of pubertal induction.
Serum Tsukushi Level Is Associated With the Severity of Liver Fibrosis Independent of Type 2 Diabetes
Authors: Lam Sum , Lee Chi-Ho , Fong Carol H Y , Wong Ying , Shiu Sammy W M , Mak Lung-Yi , Yuen Man-Fung , Lam Karen S L , Tan Kathryn C B 
Published: November 2023

Abstract

Background and Aims
Tsukushi (TSK) is a recently identified hepatokine, and we aimed to investigate the association between systemic TSK and the severity of nonalcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes mellitus (DM).

Methods
Three hundred ninety-three DM and 289 without DM individuals were recruited for transient elastography assessment to determine liver steatosis and fibrosis. Serum TSK was measured by ELISA. The presence of NAFLD was defined as controlled attenuation parameter ≥ 248 dB/m.

Results
NAFLD was present in 276 (70.2%) and 129 (44.6%) subjects with and without DM respectively, and they had higher serum TSK levels than those without NAFLD [DM group: 91.0 ng/mL (61.7-133.8) vs 82.5 (60.9-118.5), P &lt; .01 respectively; without DM group: 97.1 ng/mL (69.3-148.6) vs 80.8 (53.4-111.6) respectively, P &lt; .01]. Univariate analysis showed that serum TSK significantly correlated with the degree of steatosis and fibrosis both in subjects with and without DM. On multivariable regression analysis, only liver stiffness and estimated glomerular filtration rate were significant determinants of TSK level, and the relationship was independent of diabetes and serum adiponectin. Out of 405 subjects with NAFLD, 49 had either advanced fibrosis or cirrhosis. The area under receiver operating characteristic curve of serum TSK to indicate advanced fibrosis or cirrhosis was 0.70 (95% CI .62-.77), which was significantly better than that of fibrosis-4 index, 0.64 (95% CI .55-.72), P &lt; .05.

Conclusion
Serum TSK levels were increased in subjects with NAFLD and reflected the severity of liver fibrosis.
TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction
Authors: Guillou Anne , Kemkem Yasmine , Lafont Chrystel , Fontanaud Pierre , Calebiro Davide , Campos Pauline , Bonnefont Xavier , Fiordelisio-Coll Tatiana , Wang Ying , Brûlé Emilie , Bernard Daniel J , Le Tissier Paul , Steyn Frederik , Mollard Patrice 
Published: November 2023

Abstract
Detection of circulating TSH is a first-line test of thyroid dysfunction, a major health problem (affecting about 5% of the population) that, if untreated, can lead to a significant deterioration of quality of life and adverse effects on multiple organ systems. Human TSH levels display both pulsatile and (nonpulsatile) basal TSH secretion patterns; however, the importance of these in regulating thyroid function and their decoding by the thyroid is unknown. Here, we developed a novel ultra-sensitive ELISA that allows precise detection of TSH secretion patterns with minute resolution in mouse models of health and disease. We characterized the patterns of ultradian TSH pulses in healthy, freely behaving mice over the day-night cycle. Challenge of the thyroid axis with primary hypothyroidism because of iodine deficiency, a major cause of thyroid dysfunction worldwide, results in alterations of TSH pulsatility. Induction in mouse models of sequential TSH pulses that mimic ultradian TSH profiles in periods of minutes were more efficient than sustained rises in basal TSH levels at increasing both thyroid follicle cAMP levels, as monitored with a genetically encoded cAMP sensor, and circulating thyroid hormone. Hence, this mouse TSH assay provides a powerful tool to decipher how ultradian TSH pulses encode thyroid outcomes and to uncover hidden parameters in the TSH-thyroid hormone set-point in health and disease.