bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homoharringtonine: mechanisms, clinical applications and research progress
Authors: Wang Wen , He Lan , Lin Ting , Xiang Fulan , Wu Yibin , Zhou Fangliang , He Yingchun 
Published: January 2025

Homoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies in recent years. This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key roles in inducing apoptosis, inhibiting cell cycle progression, and reducing cell migration and invasion. Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent studies also revealing its potential neuroprotective functions. In clinical trials, Homoharringtonine has demonstrated promising efficacy in the treatment of hematological malignancies, particularly in various types such as acute myeloid leukemia and chronic myeloid leukemia. Despite the significant antitumor effects observed in clinical applications, its low bioavailability and potential side effects remain major challenges that limit its widespread use. This article details the latest research advancements aimed at enhancing the bioavailability of Homoharringtonine, including various drug delivery systems such as nanoparticles and liposomes, as well as chemical modification strategies. These approaches not only improve HHT’s bioavailability in vivo but also enhance its targeting ability while reducing toxicity to normal cells. Furthermore, the combination of HHT with other drugs presents broader prospects for clinical treatment. By exploring the diverse pharmacological activities of Homoharringtonine in depth, this article aims to provide a foundation for developing novel therapeutic approaches based on natural products, thereby advancing HHT’s application research in cancer treatment and other fields.
FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage
Authors: Wang Fan , Xu Yue , Wang Yajie , Liu Qian , Li Yanan , Zhang Weiwei , Nong Huiming , Zhang Junhong , Zhao Hao , Yang Huaqian , Guo Lingchuan , Li Jianfeng , Li Hong , Yang Qianqian 
Published: January 2025

IntroductionCochlear spiral ganglion neurons (SGNs) could be damaged by ototoxic drug, cisplatin (Cis), during which process autophagy was involved. FAM134B, the first detected endoplasmic reticulum autophagy (ER-phagy) receptor, plays an important part in the dynamic remodelling of the ER, the mutation of which affects sensory and autonomic neurons. However whether FAM134B-mediated ER-phagy involved in Cis-induced SGN damage or not was unknown. The present study was designed to determine whether FAM134B is expressed in SGNs of C57BL/6 mice and, if so, to explore the potential function of FAM134B in Cis-induced SGN damage in vitro.MethodsMiddle turns of neonatal murine cochleae were cultured and treated with 30 μM Cis in vitro. The distribution of FAM134B, morphological changes of SGNs, and the colocalization of ER segments with lysosomes were measured by immunofluorescence (IF). Apoptosis was measured by TUNEL staining. The expression of FAM134B, proteins associated with ER stress, autophagy and apoptosis was measured by western blot. The reactive oxygen specie (ROS) levels were evaluated by MitoSOX Red and 2′,7′-Dchlorodihydrofluorescein diacetate (DCFH-DA) probe. Anc80-Fam134b shRNA was used to knockdown the expression of FAM134B in SGNs.ResultsWe first found the expression of FAM134B in the cytoplasm of SGNs, especially in the fourth postnatal day mice. Results showed decreases in the number of SGNs and FAM134B expression, as well as increases of ROS level, ER stress, ER-phagy, and apoptosis after Cis stimulus. Inhibiting autophagy increased the expression of FAM134B, and aggravated Cis-induced SGN damage, while the opposite changes were observed when autophagy was activated. Additionally, co-treatment with the N-Acetyl-L-Cysteine (NAC), ROS scavenger, alleviated Cis-induced ER stress, ER-phagy, and apoptosis. What’s more, knockdown the expression of FAM134B in SGNs made SGNs more vulnerable to cisplatin-induced injury.DiscussionThe present study revealed the expression pattern of FAM134B in C57BL/6 murine SGNs for the first time. Moreover, our work further verified the protective function of FAM134B mediated by ER-phagy in Cis-induced SGN apoptosis, at least partially, correlated with the accumulation of ROS and induction of ER stress, though the detailed regulatory mechanism through which needs much more work to reveal.
Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice
Authors: Chen Dongliang , Shen Yue , Huang Fang , Huang Bo , Xu Shangfu , Li Lisheng , Liu Jie , Li Zheng , Li Xia 
Published: January 2025

BackgroundPolygonum cyrtonema Hua is a kind of traditional Chinese botanic drug. Modern pharmacological research has confirmed that Polygonum cyrtonema Hua is able to alleviate nonalcoholic fatty liver disease, but the precise mechanism requires further investigation. This study investigated the protective effects and underlying mechanisms of Polygonatum cyrtonema ethanol extract (PCE) against Non-alcoholic steatohepatitis (NASH) in mice.MethodsUHPLC-MS/MS was utilized to analyze the metabolites of PCE. The NASH mouse model was establishment in C57BL/6J mice via high-fat diet (HFD) feeding for 12 weeks, and from the 9th week, mice were gavaged with PCE (100, 300, and 900 mg/kg/day), simvastatin (4 mg/kg) or saline. One hand, liver injury was assessed by serum enzymes, biochemistry, and histopathology; On the other hand, RNA-seq, qPCR, and Western blot were employed to investigate the related molecular mechanisms.Results211 metabolites were identified through UHPLC-MS/MS analysis. PCE ameliorated HFD induced liver injury and improved hepatocellular degeneration and steatosis in a dose-dependent way. PCE restored the expression of AMPK, SIRT1, SREBP1 and PPAR-α both in mRNA and protein levels. RNAseq identified unique gene expression profiles in response to high-fat diet (HFD) compared to the PCE treatments. HFD-induced DEGs were attenuated or abolished following PCE treatments. Ingenuity pathway analysis of RNA-seq data revealed key canonical pathways and upstream molecules regulated by PCE.ConclusionOur findings confirm the ability of PCE in alleviating NASH and underscores AMPK/SIRT1 pathway as a potential theraputic target for NASH treatment.
Development and validity test of impression management efficacy scale based on self-presentation behavior of Chinese youth on social media
Authors: Liu Yixuan , Lei Ke 
Published: January 2025

IntroductionThis study seeks to develop and validate a scale for assessing Impression Management Efficacy (IME) in the context of Chinese youth’s self-presentation behaviors on social media. It aims to provide a comprehensive evaluation of their ability and self-efficacy in managing impressions within social media environments.MethodsFor this study, 18 young individuals were selected to participate in in-depth interviews. The specific dimensions of IME were identified through the application of grounded theory categorization. Subsequently, specific measurement questions were formulated by referencing the impression management scale, the social self-efficacy scale, and insights from empirical interviews, leading to the preliminary compilation of the questionnaire. A total of 920 questionnaires were then distributed for a centralized investigation. The collected data underwent repeated testing to refine and finalize the questionnaire.ResultsThis study explores the relationship between self-presentation and IME in social media contexts. Through multiple tests and empirical data analysis, IME was delineated into five distinct dimensions: identity management strategy, self-impression management strategy, communication expression efficacy, protection strategy efficacy, and self-presentation efficacy, collectively encompassing 25 measurement items. The study is inherently exploratory in nature.DiscussionThe concept of IME among young people is distinct yet related to traditional notions of impression management and social self-efficacy. While impression management primarily focuses on external behaviors, social self-efficacy assesses one’s perceived social abilities. Both concepts, along with their measurement methods, tend to be relatively singular in focus. IME, however, is closely intertwined with these concepts but possesses a unique conceptual depth and theoretical significance, setting it apart as a multifaceted and nuanced construct.
The influence of mutually beneficial and self-beneficial situations on the lying behavior and cognition of Chinese 4- to 5-year-old children
Authors: Kang Dan , Zhang Yingjie , Xu Xiwu , Li Jiajia 
Published: January 2025

BackgroundChildren’s moral development is influenced by their sociocultural context. However, relatively few studies have investigated whether the sociocultural context affects children’s lying behavior and cognition and the relation between them.MethodsThe present study was designed to examine this question in two experiments by posing two moral dilemmas: lying is good for mutually beneficial (honesty conflicts with mutual interests) and lying is good for self-beneficial (honesty conflicts with self-interests). Experiment 1 used the “hide-and-seek” game to investigate the lying behavior of 96 Chinese 4- to 5-year-old children. Experiment 2 used two videos to investigate lying cognition (conceptualization of lying, moral assessment of lying, and prediction of lying) with the same group of children.ResultsIn Experiment 1, children lied more in mutually beneficial situations than in self-beneficial situations. Experiment 2 revealed that, compared with self-beneficial situations, children in mutually beneficial situations were more likely to judge untrue statements as truth, to evaluate lying positively, and to predict that they would lie. Further, in mutually beneficial situations, children’s predicted and actual lying behaviors are significantly positively correlated.ConclusionThese findings support the folk model and highlight the influence of sociocultural factors on lying in Chinese 4- to 5-year-old children. They offer meaningful insights into the development of early moral understanding and behavior.
The Memory and Affective Flexibility Task: a new behavioral tool to assess neurocognitive processes implicated in emotion-related impulsivity and internalizing symptoms
Authors: Allen Kenneth J. D. , Elliott Matthew V. , Ronold Eivind H. , Rajgopal Nandini A. , Hammar Åsa , Johnson Sheri L. 
Published: January 2025

BackgroundCognitive rigidity and working memory impairment are established features of internalizing syndromes. Growing evidence suggests that deficits in affective control –cognitive control in the context of emotion – may underpin elevated emotion-related impulsivity in various psychiatric disorders.ObjectiveThis study examines two components of affective control (affective flexibility and emotional working memory) as potential neurocognitive processes linking emotion-related impulsivity to internalizing psychopathology.MethodUndergraduate participants (analysis n = 120) completed the Memory and Affective Flexibility Task (MAFT), a novel behavioral assessment designed to assess hot cognition in affective flexibility and emotional working memory performance, alongside self-report measures of impulsivity and symptoms of internalizing disorders.ResultsStructural equation modeling suggested that less accurate working memory during neutral trials (cool cognition) was associated with more symptoms of internalizing psychopathology. However, effects of hot working memory and affective flexibility were not significantly related to emotion-related impulsivity or psychopathology scores.ConclusionsAlthough findings provide no support for the validity of MAFT indices of hot cognition, these results replicate and extend work on the importance of cool working memory and emotion-related impulsivity as correlates of psychopathology.
Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma
Authors: Shangguan Tingting , Xu Jing , Weng Xiaochun , Lin Hao 
Published: January 2025

BackgroundRecent studies have identified a correlation between inflammation and depression. This study aims to explore the correlation between the red blood cell distribution width (RDW) to albumin ratio (RAR), a practical measure for assessing inflammation, and depression in the general population.MethodsIn this population-based cross-sectional study, data from 28932 adults aged≥18 years old in the NHANES during the period of 1999–2018 were analyzed. To examine the correlation between RAR and depression, multivariate logistic regression analyses, subgroup analyses, restricted cubic spline analyses, and interaction tests were conducted. Furthermore, a mediation analysis was performed to elucidate the role of atherogenic index of plasma (AIP) in mediating the effect of RAR on depression.ResultsMultivariate logistic regression analyses and restricted cubic splines analysis indicated that RAR can exhibit a linearly correlation with depression (OR = 1.335; 95% CI: 1.222, 1.458). Subjects in RAR Q2, Q3, Q4 groups had an increased risk on depression as 22.8%, 22.9% and 51.9% than those in the Q1 group. This positive correlation was more pronounced in those with history of cancers. The ROC analysis indicated that the area under the curve (AUC) for RAR (AUC=0.593) was significantly greater than that for RDW and albumin individually. Mediation analysis indicated that AIP mediated 7.8% of the correlation of RAR with depression.ConclusionsThe findings of this study indicated a significant linear positive correlation between RAR and the prevalence of depression, with AIP serving as a mediator.
Motivational strategies reduce recidivism and enhance treatment adherence in intimate partner violence perpetrators with substance use problems
Authors: Lila Marisol , Expósito-Álvarez Cristina , Roldán-Pardo Manuel 
Published: January 2025

IntroductionThe incorporation of motivational strategies has shown promising results in increasing the effectiveness of intervention programs for intimate partner violence perpetrators, such as enhancing treatment adherence and decreasing risk of intimate partner violence recidivism. This could be particularly important for participants with alcohol and/or other drug use problems (ADUPs), who are at higher risk of recidivating and dropping out from the intervention. Consequently, there is a need to study whether motivational strategies are also effective for high-risk and highly resistant participants. The aim of this study was to determine whether the incorporation of motivational strategies led to improved outcomes in participants with ADUPs compared to those without.MethodsParticipants were intimate partner violence male perpetrators who received a standard intervention (n = 349) or a standard intervention adding an individualized motivational plan (n = 367). Data on official intimate partner violence recidivism, intervention dose, and dropout were collected after the end of the intervention. Comparisons were made between participants with and without ADUPs in each intervention condition.ResultsResults showed that in the full sample of participants, irrespective of their condition, those with ADUPs presented a higher recidivism (p = .007) and dropout rate (p = .003) and lower intervention dose than those without ADUPs (p = .005). When only considering participants in the standard intervention, results also showed that intimate partner violence perpetrators with ADUPs had a higher recidivism (p = .025) and dropout rate (p = .015) and lower intervention dose (p = .048) than those without. However, there were no significant differences between participants with and without ADUPs in the standard intervention adding an individualized motivational plan.DiscussionWhen incorporating motivational strategies into the standard interventions for intimate partner violence perpetrators, disparities between participants with and without ADUPs were mitigated. Specifically, participants with ADUPs showed similar outcomes to those without ADUPs after receiving the standard intervention adding an individualized motivational plan. Our results suggest that motivational strategies may be effective in reducing intimate partner violence recidivism and improving treatment adherence in high-risk and highly resistant intimate partner violence perpetrators.
The knowledge, attitude, and practice toward fall prevention of parturients in the obstetric inpatient wards: a comparative cross-sectional study between nurses and parturients
Authors: Wen Jing , Wen Jiao , Jing Wenjuan , He Hongmei , Ren Jianhua 
Published: January 2025

ObjectiveThis study aimed to compare the knowledge, attitudes, and practices of parturients and nurses regarding fall prevention among parturients, with the goal of understanding the cognitive factors contributing to post-delivery fall.MethodsA cross-sectional survey was conducted among obstetric nurses and women in obstetric ward within 2 days after vaginal delivery. The survey instrument included a self-design questionnaire comprising a demographic information sheet and a KAP questionnaire, which demonstrated acceptable reliability and validity.ResultsA total of 705 nurses and 1,220 parturients completed the survey. Over half of both nurses and parturients exhibited reasonably good knowledge, positive attitudes and appropriate practices related to fall prevention. Significant associations were identified between the education level of parturients and their knowledge and attitudes. Nurses scored lower in the attitude dimension compared to parturients (4.32 ± 1.01 vs. 4.84 ± 0.36, P &lt; 0.001), whereas nurses scored higher than parturients in the practice dimension (3.76 ± 0.44 vs. 3.57 ± 0.48, P &lt; 0.001).ConclusionNurses should focus on enhancing the fall practices of parturients by emphasizing key points for fall prevention and providing guidance in situations of improper behaviors (e.g., unaccompanied activities). Further education programs for nurses should prioritize increasing their confidence and proficiency in fall prevention.
Machine learning and public health policy evaluation: research dynamics and prospects for challenges
Authors: Li Zhengyin , Zhou Hui , Xu Zhen , Ma Qingyang 
Published: January 2025

BackgroundPublic health policy evaluation is crucial for improving health outcomes, optimizing healthcare resource allocation, and ensuring fairness and transparency in decision-making. With the rise of big data, traditional evaluation methods face new challenges, requiring innovative approaches.MethodsThis article reviews the principles, scope, and limitations of traditional public health policy evaluation methods and explores the application of machine learning in evaluating public health policies. It analyzes the specific steps for applying machine learning and provides practical examples. The challenges discussed include model interpretability, data bias, the continuation of historical health inequities, and data privacy concerns, while proposing ways to better apply machine learning in the context of big data.ResultsMachine learning techniques hold promise in overcoming some limitations of traditional methods, offering more precise evaluations of public health policies. However, challenges such as lack of model interpretability, the perpetuation of health inequities, data bias, and privacy concerns remain significant.DiscussionTo address these challenges, the article suggests integrating data-driven and theory-driven approaches to improve model interpretability, developing multi-level data strategies to reduce bias and mitigate health inequities, ensuring data privacy through technical safeguards and legal frameworks, and employing validation and benchmarking strategies to enhance model robustness and reproducibility.
Assessment of the effect of agro-industrial by-products rich in polyphenols on in vitro fermentation and methane reduction in sheep
Authors: Vastolo Alessandro , Mora Blandine , Kiatti Dieu donné , Nocerino Martina , Haroutounian Serkos , Baka Rania D. , Ligda Panagiota , Cutrignelli Monica Isabella , Niderkorn Vincent , Calabrò Serena 
Published: January 2025

IntroductionThis study aimed to evaluate, using the in vitro gas production technique, the effect of including eight agro-industrial by-products (carob, grape, two types of olive pomace, citrus pulp, tomato, and hazelnut skin) on fermentation end-products, ruminal degradability, and methane production in sheep diets.MethodsThe by-products were included at 10% dry matter in the control (CTR) diet, commonly adopted for adult sheep (80% natural grassland and 20% concentrate), and incubated at 39°C under anaerobic conditions.Result and discussionAfter 24 h of the incubation, the organic matter degradability (OMD24h) and methane production were assessed. After 120 h of the incubation, the organic matter degradability (OMD120h), volume of gas produced (OMCV), fermentation kinetics, pH, volatile fatty acids (VFAs), and ammonia were evaluated. Dunnett’s test was used to compare the differences between the control and experimental diets, and multivariate analysis was performed to highlight the differences among the diets based on their in vitro characteristics. The results indicated that the inclusion of the by-products decreased the degradability and increased gas production after 120 h of the incubation. The by-products from the hazelnuts, citrus, grapes, and tomatoes significantly (p &lt; 0.001) reduced the methane production, whereas the pomegranate, grape, 3-phase olive cake, tomato, and hazelnut by-products significantly (p &lt; 0.001) increased the acetate production. The multivariate analysis showed that the butyrate concentration was a determining factor in the differences between the diets. The concentration of polyphenols in the selected agro-industrial by-products could modify fermentation parameters and metabolic pathways, leading to reduced methane production.
Une épigramme pour célébrer l’expansion lagide en mer Érythrée ? À propos du papyrus d’El Hibeh (seconde moitié du IIIe siècle av. J.-C.)
Authors: Schneider Pierre 
Published: January 2025

Les Lagides, à l’initiative de Ptolémée II, ont accordé une attention particulière aux régions maritimes et terrestres qui se situaient au sud de l’Égypte. Quelques documents, notamment la stèle de Pithom, montrent que cette présence en Afrique orientale et en mer Rouge a contribué à accroître le prestige royal. Une épigramme fragmentaire publiée par F. Maltomini, où sont mentionnées la mer Érythrée et la fondation de Ptolémaïs des Chasses, semble confirmer cette idée.