bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multi-stage Optimization Strategy Based on Fuzzy QFD and Fuzzy Swara to Adopt Blockchain Technology in the Drug Supply Chain
Authors: Yazdi Naghmeh Talebi 
Published: December 2023

Introduction: Utilizing blockchain technology helps to address issues that the supply chain faces, including the intricate connections between chain network members, regulation of the distribution network, and inventory management.
Objective: To adopt blockchain technology in the drug supply chain, this study aims to offer a multi-stage optimization strategy based on Swara and QFD approaches and a zero-one nonlinear optimization problem employing a fuzzy approach.
Methods: First, field and library research was conducted to identify the barriers to the adoption of blockchain technology in the drug supply chain and the ways to overcome these barriers. The relevance of the barriers is ascertained using the fuzzy Swara approach following their refinement employing the Friedman test. The output is entered as an input in the house of quality (HOQ) rows, while the barrier-reducing techniques are presented in the columns. These approaches to reducing barriers are arranged in rows in the second phase of the house of quality.
Results: Among the criteria of the barrier-reduction approach, the Performance Expectancy criterion with a score of 0.0521 has the greatest score, and the criterion of Focusing on the Major Points has the minimum score, as determined by the findings of the fuzzy Swara model. The criterion of Enhancing Transparency with a score of 0.5374 and Reducing Risk with a score of 0.4045 have the maximum, and Sustainability Performance with a score of 0.07 has the minimum score, according to the findings concerning the objectives of blockchain technology adoption in the drug supply chain. The criterion of lack of customers' awareness and attitude about sustainability and blockchain technology has the greatest score among the barriers to adoption, scoring 0.521, and the criterion of difficulty in altering organizational culture, scoring 0.033, has the minimum value.
Conclusion: Based on the results of the fuzzy house of quality, we concluded that, for the adoption of blockchain technology in the drug supply chain, the eighth (long-term perspective), first (performance expectation), and tenth (focused on the primary strengths) strategies are more beneficial. In addition, it was demonstrated that the second (Effort Expectation), ninth (information sharing), and sixth (Trust) strategies have poor rankings.
Prophylactic Oropharyngeal Surfactant for Preterm Newborns at Birth
Authors: Murphy Madeleine C. , Miletin Jan , Klingenberg Claus , Guthe Hans Jørgen , Rigo Vincent , Plavka Richard , Bohlin Kajsa , Barroso Pereira Almerinda , Juren Tomáš , Alih Ekele , Galligan Marie , O’Donnell Colm P. F. 
Published: December 2023

ImportancePreterm newborns at risk of respiratory distress syndrome are supported with continuous positive airway pressure (CPAP). Many newborns worsen despite CPAP and are intubated for surfactant administration, an effective therapy for treatment of respiratory distress syndrome. Endotracheal intubation is associated with adverse effects. Pharyngeal administration of surfactant to preterm animals and humans has been reported as an alternative.ObjectiveTo assess whether giving prophylactic oropharyngeal surfactant to preterm newborns at birth would reduce the rate of intubation for respiratory failure.Design, Setting, and ParticipantsThis unblinded, parallel-group randomized clinical trial (Prophylactic Oropharyngeal Surfactant for Preterm Infants [POPART]) was conducted from December 17, 2017, to September 11, 2020, at 9 tertiary neonatal intensive care units in 6 European countries. Newborns born before 29 weeks of gestation without severe congenital anomalies, for whom intensive care was planned, were eligible for inclusion. The data were analyzed from July 27, 2022, to June 20, 2023.InterventionNewborns were randomly assigned to receive oropharyngeal surfactant at birth in addition to CPAP or CPAP alone. Randomization was stratified by center and gestational age (GA).Main Outcomes and MeasuresThe primary outcome was intubation in the delivery room for bradycardia and/or apnea or in the neonatal intensive care unit for prespecified respiratory failure criteria within 120 hours of birth. Caregivers were not masked to group assignment.ResultsAmong 251 participants (mean [SD] GA, 26 [1.5] weeks) who were well matched at study entry, 126 (69 [54.8%] male) with a mean (SD) birth weight of 858 (261) grams were assigned to the oropharyngeal surfactant group, and 125 (63 [50.4%] male) with a mean (SD) birth weight of 829 (253) grams were assigned to the control group. The proportion of newborns intubated within 120 hours was not different between the groups (80 [63.5%) in the oropharyngeal surfactant group and 81 [64.8%] in the control group; relative risk, 0.98 [95% CI, 0.81-1.18]). More newborns assigned to the oropharyngeal surfactant group were diagnosed with and treated for pneumothorax (21 [16.6%] vs 8 [6.4%]; P = .04).Conclusions and RelevanceThis randomized clinical trial found that administration of prophylactic oropharyngeal surfactant to newborns born before 29 weeks’ GA did not reduce the rate of intubation in the first 120 hours of life. These findings suggest that administration of surfactant into the oropharynx immediately after birth in addition to CPAP should not be routinely used.Trial RegistrationEudraCT: 2016-004198-41
Lubricating Micro‐Interface Assisted General Strategy for Preparing dECM‐Microparticle–Based Heterogeneous Granular Inks toward 3D Printing
Authors: Zhang Kunxi , Zhu Yinan , Wang Tao , Niu Dawei , Xiahou Zijie , Wang Hongzhong , Fu Peiliang , Cui Haiyan , Yin Jingbo 
Published: December 2023

AbstractDecellularized extracellular matrix (dECM) retains the bioactive components to mimic tissue‐specific microenvironment. Designing dECM‐based inks for 3D printing to prepare scaffolds can enhance the regeneration of corresponding tissues. However, due to the strict requirements for inks, how to efficiently prepare dECM‐based inks is a challenge. Inspired by granular lubrication, the present study proposes an effective and general method for preparing granular ink from dECM microparticles (MP) with high content. Through dopamine polymerization, dECM‐MPs are coated with polydopamine (PDA). Meanwhile, gelatin methacryloyl (GelMA)‐based microspheres (GelMA‐MSs) are prepared with available double bonds. dECM‐MPs (30–40 wt%) and GelMA‐MSs assemble to form a granular ink, exhibiting well‐performed extrudability, plasticity, and fidelity. Further inspired by joint lubrication, hyaluronic acid (HA) is introduced into PDA coating and GelMA‐MSs to reduce the micro‐interface friction, further promoting the printability and broadening the printable window of dECM‐MPs content to 30–60 wt%. Osteochondral scaffold and skin wound dressing are fabricated through 3D printing from the corresponding dECM‐MPs, enhancing the regeneration of the corresponding tissues in vivo. Especially, the realization of printability of highly rigid dECM‐MPs confirms the universality, reliability and efficiency of the present strategy.
Surface‐Sensitive Detection of Magnetic Phase Transition in Van Der Waals Magnet CrSBr
Authors: Pei Fangfang , Yu Jingjing , Zhou Jiayuan , Wang Siyu , Liu Daxiang , Yuan Yanan , Xi Lei , Jin Feng , Kan Xucai , Wang Chao , Wang Lingfei , Yan Wensheng , Wu Yizheng , Wang Shouguo , Chen Kai , Ma Tianping , Liu Xue , Yang Mengmeng , Li Qian 
Published: December 2023

Abstract2D magnets have recently drawn enormous interest. As an air‐stable A‐type van der Waals antiferromagnet (AFM), CrSBr has attracted great attention but has also led to controversies about its large‐span ordering temperatures. Herein, a systematic study of the magnetic phase transition in single‐crystalline CrSBr with ultrahigh‐quality through surface‐sensitive X‐ray magnetic linear dichroism and X‐ray magnetic circular dichroism measurements combined with vibrating sample magnetometry for characterization of bulk magnetization is reported. The interlayer AFM order of both surface and bulk CrSBr is revealed to maintain a similar Néel temperature within the range of 132–142 K. However, the intralayer ferromagnetic (FM) order of surface CrSBr is found to sustain up to ≈238 K, 70 K higher than the value obtained from the bulk CrSBr, demonstrating a dramatically different surface and bulk Curie temperature in CrSBr. Moreover, a half‐filled t2g electronic state for Cr3+ ions with magnetic moment of ≈3 µB/Cr in CrSBr is clearly identified. These results enrich the understanding of the electronic structure and magnetism in CrSBr, providing this material as a promising building block for future spintronic devices.
A Ferroelectric Nonlinear Optical Crystal for Deep‐UV Quasi‐Phase‐Matching
Authors: Song Yipeng , Yu Hongwei , Li Bingxuan , Li Xiaoqi , Zhou Yang , Li Yanqiang , He Chao , Zhang Ge , Luo Junhua , Zhao Sangen 
Published: December 2023

AbstractPhase matching is indispensable for high efficiency of second‐order nonlinear optical (NLO) crystals. Thousands of these crystals rely on birefringence phase matching, whereas only a few of them are quasi‐phase matching without the restriction of birefringence. Herein, using oriented seeds inch‐sized LiNH4SO4 (LAS) single crystals are successfully grown. LAS is NLO‐active with a very short deep‐UV absorption edge of 171 nm and high laser damage threshold up to 1.47 GW cm−2 at 1064 nm, 10 ns, but its birefringence is merely 0.0078@532 nm, which is too small to realize birefringence phase matching in deep‐UV region. Fortunately, P−E hysteresis loop, variable‐temperature NLO tests, and ferroelectric domain observations confirm that LAS is ferroelectric. Furthermore, LAS exhibits small refractive index dispersion resulting in a relatively long periodic length of 1.4 µm and its single domain structure can be easily obtained by electrical poling. These attributes make LAS a scarce NLO candidate for deep‐UV quasi‐phase matching. This work highlights the longly overlooked potential of sulfates and provides new opportunities for deep‐UV NLO materials.
MXene‐Interconnected Two‐Terminal, Mechanically‐Stacked Perovskite/Silicon Tandem Solar Cell with High Efficiency
Authors: Han Tianjiao , Zhu Weidong , Wang Tianran , Yang Mei , Zhou Yuanbo , Xi He , Zhong Peng , Chen Dazheng , Zhang Jincheng , Zhang Chunfu , Hao Yue 
Published: December 2023

AbstractTwo‐terminal, mechanically‐stacked perovskite/silicon tandem solar cells offer a feasible way to achieve power conversion efficiencies (PCEs) of over 35%, provided that the state‐of‐the‐art industrial silicon solar cells and perovskite solar cells (PSCs) are fully compatible with one another. Herein, two‐terminal, mechanically‐stacked perovskite/silicon tandem solar cells are developed by mechanically interconnecting semitransparent PSCs and TOPCon solar cells with a MXene interlayer. The semitransparent PSCs are made from wide‐bandgap perovskite Cs0.15FA0.65MA0.20Pb(I0.80Br0.20)3 films. Furthermore, the co‐additives KPF6 and CH3NH3Cl(MACl) are employed to reduce grain boundaries and intragranular defects in the perovskite, boosting the PCE of the semitransparent PSCs to a record‐high value of 20.96% under reverse scan (RS) through a reduction in non‐radiative recombination probability. These optimized semitransparent PSCs are then employed in MXene‐interconnected two‐terminal, mechanically‐stacked tandem solar cells. The enhanced interfacial carrier transportation, with minimal influence on light transmission, imparted by the MXene flakes allows the tandem solar cells to achieve a stabilized PCE of 29.65%. The tandem cells also exhibit acceptable operational stability and are able to retain ≈93% and 92% of their initial PCEs after 120 min of continuous illumination or storage in ambient air for 1000 h, respectively.
Pump‐Wavelength Sensitive Terahertz Spatiotemporal Metasurface
Authors: Wang Guocui , Hu Bin , Zhao Huan , Xu Meng , Wang Xinyue , Ye Jiasheng , Sun Wenfeng , Feng Shengfei , Han Peng , Wang Xinke , Zhang Bo , Zhang Yan 
Published: December 2023

AbstractTerahertz (THz) technologies hold great promise for nondestructive precision imaging and wireless communication. Active tailoring of the THz field is highly desired for enhancing the resolution of imaging and increasing communication capacity. However, most THz field manipulation devices are limited by passive modulation and single‐dimensional external triggers. In this study, an innovative spatiotemporally tunable metasurface is proposed for the multidimensional dynamic manipulation of the THz field. The device combines a metasurface and two‐dimensional perovskite materials: the metasurface is responsible for modulation of the THz field in the spatial dimension, while the perovskite is responsible for modulation of the THz field in the temporal dimension. The pumping wavelength is an extra dimension for selectively switching the transmission of the THz field owing to the bandgap tunability of the perovskite. Accordingly, the functions of the metadevice can be multistage‐switched utilizing the pump‐wavelength sensitive control scheme. Based on this platform, dynamic switching of a THz multifocal lens and a dynamic display of holographic characters are experimentally demonstrated. The proposed metasurface provides a new pathway for multiple orders to manipulate the THz field dynamically, which can be used to realize more multifunctional dynamic meta‐devices.
Organic Acid‐Based Hydrothermal Leaching of LiFePO4 Cathode Materials
Authors: Li Zixian , Zheng Qingxin , Nakajima Akitoshi , Zhang Zhengyang , Watanabe Masaru 
Published: December 2023

AbstractThis study conducts hydrothermal leaching of commercial LiFePO4 (LFPO) cathode materials with oxalic acid, citric acid, or glycine without any other oxidants or reductants. Of these acids, glycine exhibits the weakest leaching behavior, with the leaching efficiency of lithium (Li), iron (Fe), or phosphorus (P) less than 15% even at 200 °C and an acid concentration of 0.8 mol L−1 for 10 min. For oxalic acid, at 200 °C for 10 min, with a pulp density of 30 g L−1 and an acid concentration of 0.8 mol L−1, the leaching efficiencies for Li and P are 100% and 97%, respectively, and 98.5% of Fe precipitates as iron oxalate (FeC2O4) that can be used as a precursor for preparing LFPO cathode materials. Citric acid shows the highest leaching efficiency for Li, Fe, and P, reaching 96%, 100%, and 88%, respectively, at 90 °C for 10 min with a pulp density of 10 g L−1 and an acid concentration of 0.8 mol L−1. The continuous hydrothermal leaching of LFPO cathode materials with citric acid is first achieved. These results clarify the superiority of citric acid over oxalic acid and glycine with respect to the leaching efficiency for Li, Fe, and P from LFPO batteries under hydrothermal conditions.
Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges
Authors: Wang Yumei , Fang Liuru , Wang Yuhua , Xiong Zuzhao 
Published: December 2023

AbstractEarly clinical diagnosis, effective intraoperative guidance, and an accurate prognosis can lead to timely and effective medical treatment. The current conventional clinical methods have several limitations. Therefore, there is a need to develop faster and more reliable clinical detection, treatment, and monitoring methods to enhance their clinical applications. Raman spectroscopy is noninvasive and provides highly specific information about the molecular structure and biochemical composition of analytes in a rapid and accurate manner. It has a wide range of applications in biomedicine, materials, and clinical settings. This review primarily focuses on the application of Raman spectroscopy in clinical medicine. The advantages and limitations of Raman spectroscopy over traditional clinical methods are discussed. In addition, the advantages of combining Raman spectroscopy with machine learning, nanoparticles, and probes are demonstrated, thereby extending its applicability to different clinical phases. Examples of the clinical applications of Raman spectroscopy over the last 3 years are also integrated. Finally, various prospective approaches based on Raman spectroscopy in clinical studies are surveyed, and current challenges are discussed.
The Interplay Between HIF‐1α and EZH2 in Lung Cancer and Dual‐Targeted Drug Therapy
Authors: Wang Jianmin , Yang Cheng , Xu Huashen , Fan Xinyu , Jia Lina , Du Yang , Liu Shougeng , Wang Wenjing , Zhang Jie , Zhang Yu , Wang Xiaoxue , Liu Zhongbo , Bao Jie , Li Songping , Yang Jingyu , Wu Chunfu , Tang Jing , Chen Guoliang , Wang Lihui 
Published: December 2023

AbstractInteractions between oncogenic proteins contribute to the phenotype and drug resistance. Here, EZH2 (enhancer of zest homolog 2) is identified as a crucial factor that mediates HIF‐1 (hypoxia‐inducible factor) inhibitor resistance. Mechanistically, targeting HIF‐1 enhanced the activity of EZH2 through transcription activation of SUZ12 (suppressor of zest 12 protein homolog). Conversely, inhibiting EZH2 increased HIF‐1α transcription, but not the transcription of other HIF family members. Additionally, the negative feedback regulation between EZH2 and HIF‐1α is confirmed in lung cancer patient tissues and a database of cell lines. Moreover, molecular prediction showed that a newly screened dual‐target compound, DYB‐03, forms multiple hydrogen bonds with HIF‐1α and EZH2 to effectively inhibit the activity of both targets. Subsequent studies revealed that DYB‐03 could better inhibit migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo compared to single agent. DYB‐03 showed promising antitumor activity in a xenograft tumor model by promoting apoptosis and inhibiting angiogenesis, which could be almost abolished by the deletion of HIF‐1α and EZH2. Notably, DYB‐03 could reverse 2‐ME2 and GSK126‐resistance in lung cancer. These findings clarified the molecular mechanism of cross‐regulation of HIF‐1α and EZH2, and the potential of DYB‐03 for clinical combination target therapy.
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis
Authors: Yu Lisha , Liu Zhaodi , Tong Zongrui , Ding Yihang , Qian Zhefeng , Wang Weilin , Mao Zhengwei , Ding Yuan 
Published: December 2023

AbstractAchieving hemostasis effectively is essential for surgical success and excellent patient outcomes. However, it is challenging to develop hemostatic adhesives that are fast‐acting, strongly adherent, long‐lasting, and biocompatible for treating hemorrhage. In this study, a sequential crosslinking fibrin glue (SCFG) is developed, of which the first network of the fibrin glue forms in situ within 2 s to act as an initial physical barrier and locks the gelatin methacryloyl precursor for tight construction of the second network to enhance wet adhesion and durability for tissues covered with blood. The sequential crosslinking glue can provide large pressures (≈280 mmHg of burst pressure), makes strong (38 kPa of shear strength) and tough (≈60 J m−2 of interfacial toughness) interfaces with wet tissues, and outperforms commercial hemostatic agents and gelatin methacryloyl. SCFG are demonstrated as an effective and safe sealant to enhance the treatment outcomes of bleeding tissues in rat, rabbit, and pig models. The ultrafast gelation, strong adhesion and durability, excellent compatibility, and easy manufacture of SCFG make it a promising hemostatic adhesive for clinical applications.
Sn Composition Engineering Toward the Breakthrough of Transparent Front Electrodes for Efficient and Stable Perovskite Solar Cells
Authors: Seok Hae‐Jun , Park Jung‐Min , Lan Shuai , Kim Han‐Ki 
Published: December 2023

AbstractTo overcome the Shockley–Queisser limit, studies have focused on improving the efficiency of perovskite solar cells (PSCs) through several optimization and tandem‐structure design strategies. Furthermore, the significance of emerging transparent front electrodes (TFEs), which exert a direct and substantial influence on the performance of PSCs, is on the rise. Therefore, further research must be conducted to validate these effects in improving the existing performance of PSCs. Thus, this study developed a composition‐engineered indium tin oxide (CE‐ITO) TFE that outperforms commercial ITO (C‐ITO; 10 at.% Sn doped ITO) for efficient and stable PSCs. The CE‐ITO electrode (7.50 at.% Sn doped ITO) has a large columnar structure and good thermal stability, which are ideal for high‐performance PSCs. Compared to C‐ITO, CE‐ITO has a smoother surface, higher conductivity, lower resistivity, and improved optical transmittance in the active layer. These contribute to the larger perovskite active‐ and electron‐transport layers, less active‐layer degradation, and lower shunt resistance. The various merits of CE‐ITO enable high‐performance PSCs with a maximum power conversion efficiency of 23.35% and long‐term stability by simply substituting C‐ITO with optimal CE‐ITO.
Synergistic Defect Healing and Device Encapsulation via Structure Regulation by Silicone Polymer Enables Durable Inverted Perovskite Photovoltaics with High Efficiency
Authors: Wang Tong , Wan Zhi , Min Xin , Chen Rui , Li Yuke , Yang Jiabao , Pu Xingyu , Chen Hui , He Xilai , Cao Qi , Feng Guangpeng , Chen Xingyuan , Ma Zhiyong , Jiang Long , Liu Zonghao , Li Zhen , Chen Wei , Li Xuanhua 
Published: December 2023

AbstractPolymers play a crucial role in promoting the progress of high‐performance inverted perovskite solar cells (PSCs). However, few polymers have simultaneously achieved defect passivation and device encapsulation in PSCs. Herein, a telechelic silicone polymer (poly(dimethylsiloxane‐co‐methylsiloxane acrylate) [PDMA]) is introduced, which possesses crosslinking capability to enable structure regulation through a condensation reaction. By leveraging the advantages of the polymers before and after crosslinking, a synergistic strategy of defect healing and device encapsulation for PSCs is developed via the application of the targeted polymer. PDMA as additives anchors tightly at the grain boundaries (GBs) and bridges the perovskite grains, achieving defect passivation and GBs crosslinking, increasing the efficiency of inverted PSCs from 22.32% to 24.41%. Crosslinked PDMA (CPDMA) is used as an encapsulant to encapsulate the entire device, enabling non‐destructive encapsulation at room temperature and inhibiting perovskite degradation under photothermal aging. Remarkably, the PDMA‐modified device with CPDMA encapsulation maintains 98% of its initial efficiency after 1200 h under continuous illumination at 55 ± 5 °C and retains 95% of its original efficiency after 1000 h of damp heat testing, meeting one of the IEC61215:2016 standards.
Photocatalytic Aldehyde C−H Bond Phosphonioethylation with Vinylphosphonium Bromide
Authors: Mori Haruna , Yoshida Masaki , Sawamura Masaya , Masuda Yusuke 
Published: December 2023

AbstractPhotocatalytic C−H bond phosphonioethylation of aldehydes with vinylphosphonium bromide has been developed. Various β‐phosphonioalkylketones are synthesized from readily available aldehydes under neutral conditions. Mechanistic studies suggest that C−H activation of aldehydes occurs through hydrogen‐atom transfer by a bromine radical and that an alcoholic additive, which showed marked effects in increasing the efficiency of the reaction, is involved in the reaction as a proton source.