bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Spatiotemporal Variability of Tropical Orographic Rainfall Using Convective Plume Buoyancy
Authors: Nicolas Quentin , Boos William R. 
Published: December 2023

Abstract
Mechanical forcing by orography affects precipitating convection across many tropical regions, but controls on the intensity and horizontal extent of the orographic precipitation peak and rain shadow remain poorly understood. A recent theory explains this control of precipitation as arising from modulation of lower-tropospheric temperature and moisture by orographic mechanical forcing, setting the distribution of convective rainfall by controlling parcel buoyancy. Using satellite and reanalysis data, we evaluate this theory by investigating spatiotemporal precipitation variations in six mountainous tropical regions spanning South and Southeast Asia, and the Maritime Continent. We show that a strong relationship holds in these regions between daily precipitation and a measure of convective plume buoyancy. This measure depends on boundary layer thermodynamic properties and lower-free-tropospheric moisture and temperature. Consistent with the theory, temporal variations in lower-free-tropospheric temperature are primarily modulated by orographic mechanical lifting through changes in cross-slope wind speed. However, winds directed along background horizontal moisture gradients also influence lower-tropospheric moisture variations in some regions. The buoyancy measure is also shown to explain many aspects of the spatial patterns of precipitation. Finally, we present a linear model with two horizontal dimensions that combines mountain wave dynamics with a linearized closure exploiting the relationship between precipitation and plume buoyancy. In some regions, this model skillfully captures the spatial structure and intensity of rainfall; it underestimates rainfall in regions where time-mean ascent in large-scale convergence zones shapes lower-tropospheric humidity. Overall, these results provide new understanding of fundamental processes controlling subseasonal and spatial variations in tropical orographic precipitation.
Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL
Authors: Bastian Lorenz , Beder Thomas , Barz Malwine J. , Bendig Sonja , Bartsch Lorenz , Walter Wencke , Wolgast Nadine , Brändl Björn , Rohrandt Christian , Hansen Björn-Thore , Hartmann Alina M. , Iben Katharina , Das Gupta Dennis , Denker Miriam , Zimmermann Johannes , Wittig Michael , Chitadze Guranda , Neumann Martin , Schneller Folker , Fiedler Walter , Steffen Björn , Stelljes Matthias , Faul Christoph , Schwartz Stefan , Müller Franz-Josef , Cario Gunnar , Harder Lana , Haferlach Claudia , Pfeifer Heike , Gökbuget Nicola , Brüggemann Monika , Baldus Claudia D. 
Published: December 2023

Abstract
Distinct diagnostic entities within BCR::ABL1-positive acute lymphoblastic leukemia (ALL) are currently defined by the International Consensus Classification of myeloid neoplasms and acute leukemias (ICC): “lymphoid only”, with BCR::ABL1 observed exclusively in lymphatic precursors, vs “multilineage”, where BCR::ABL1 is also present in other hematopoietic lineages. Here, we analyzed transcriptomes of 327 BCR::ABL1-positive patients with ALL (age, 2-84 years; median, 46 years) and identified 2 main gene expression clusters reproducible across 4 independent patient cohorts. Fluorescence in situ hybridization analysis of fluorescence-activated cell-sorted hematopoietic compartments showed distinct BCR::ABL1 involvement in myeloid cells for these clusters (n = 18/18 vs n = 3/16 patients; P &lt; .001), indicating that a multilineage or lymphoid BCR::ABL1 subtype can be inferred from gene expression. Further subclusters grouped samples according to cooperating genomic events (multilineage: HBS1L deletion or monosomy 7; lymphoid: IKZF1-/- or CDKN2A/PAX5 deletions/hyperdiploidy). A novel HSB1L transcript was highly specific for BCR::ABL1 multilineage cases independent of HBS1L genomic aberrations. Treatment on current German Multicenter Study Group for Adult ALL (GMALL) protocols resulted in comparable disease-free survival (DFS) for multilineage vs lymphoid cluster patients (3-year DFS: 70% vs 61%; P = .530; n = 91). However, the IKZF1-/- enriched lymphoid subcluster was associated with inferior DFS, whereas hyperdiploid cases showed a superior outcome. Thus, gene expression clusters define underlying developmental trajectories and distinct patterns of cooperating events in BCR::ABL1-positive ALL with prognostic relevance.
Adrenal cortical adenoma arising in the setting of renal–adrenal fusion: a case report and review of the literature
Authors: Wang Samuel R. , Morris Richard , Taraif Suad , Aneja Amandeep 
Published: December 2023

Abstract
Background
Renal–adrenal fusion is a rare entity resulting from incomplete encapsulation of the adrenal gland and kidney. Only 18 cases have been reported in English literature to date.

Case presentation
Our patient is a 77-year-old African American female who presented with a systolic blood pressure of 200 mmHg. Computed tomography showed an enhancing 9 × 6 cm mass anterior and medial to the left kidney. The patient underwent a left adrenalectomy with partial nephrectomy. Gross and histologic examinations revealed an adrenal cortical adenoma and renal–adrenal fusion.

Conclusion
Renal–adrenal fusion may pose a diagnostic challenge, particularly when there is a concurrent adrenal adenoma. It is important to be aware of this uncommon anomaly to avoid misdiagnosis and overtreatment.
Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal
Authors: Choleva Lauryn , Wang Peng , Liu Hongtao , Wood Olivia , Lambertini Luca , Scott Donald K , Karakose Esra , Stewart Andrew F 
Published: December 2023

Abstract
Mutations in CDKN1C, encoding p57KIP2, a canonical cell cycle inhibitor, underlie multiple pediatric endocrine syndromes. Despite this central role in disease, little is known about the structure and function of p57KIP2 in the human pancreatic beta cell. Since p57KIP2 is predominantly nuclear in human beta cells, we hypothesized that disease-causing mutations in its nuclear localization sequence (NLS) may correlate with abnormal phenotypes. We prepared RIP1 insulin promoter-driven adenoviruses encoding deletions of multiple disease-associated but unexplored regions of p57KIP2 and performed a comprehensive structure-function analysis of CDKN1C/p57KIP2. Real-time polymerase chain reaction and immunoblot analyses confirmed p57KIP2 overexpression, construct size, and beta cell specificity. By immunocytochemistry, wild-type (WT) p57KIP2 displayed nuclear localization. In contrast, deletion of a putative NLS at amino acids 278–281 failed to access the nucleus. Unexpectedly, we identified a second downstream NLS at amino acids 312–316. Further analysis showed that each individual NLS is required for nuclear localization, but neither alone is sufficient. In summary, p57KIP2 contains a classical bipartite NLS characterized by 2 clusters of positively charged amino acids separated by a proline-rich linker region. Variants in the sequences encoding these 2 NLS sequences account for functional p57KIP2 loss and beta cell expansion seen in human disease.
Strategic Masochism
Authors: Perat Katja 
Published: December 2023

Abstract
This essay examines how Stanisław Lem mobilizes the genre of science fiction to portray regional Central European concerns as structural conditions of semiperiphery. The essay centers on Lem’s interest in illegibility, which defines him as a novelist and a critic, showing how his argument against the US monopoly within the genre of science fiction is reflected in his novels. Focusing on Lem’s paralleling of female masochism and epistemological critique, the essay reads Solaris as a novel invested in inspecting the interrelatedness of systems of oppression.
Postoperative Complications After Neoadjuvant Chemotherapy Versus Upfront Surgery in Gastric Adenocarcinoma: A Population-Based Nationwide Study in Finland
Authors: Putila Emilia , Helminen Olli , Helmiö Mika , Huhta Heikki , Jalkanen Aapo , Kallio Raija , Koivukangas Vesa , Kokkola Arto , Laine Simo , Lietzen Elina , Louhimo Johanna , Meriläinen Sanna , Pohjanen Vesa-Matti , Rantanen Tuomo , Junttila Anna , Ristimäki Ari , Räsänen Jari V. , Saarnio Juha , Sihvo Eero , Toikkanen Vesa , Tyrväinen Tuula , Valtola Antti , Kauppila Joonas H. ,   the FINEGO Group
Published: December 2023

Abstract
Background
To date, no large population-based studies have compared complications and short-term outcomes between neoadjuvant chemotherapy and upfront surgery in gastric cancer. More nationwide studies with standardized reporting on complications are needed to enable international comparison between studies. This study aimed to compare postoperative complications between neoadjuvant therapy and upfront surgery after gastrectomy for gastric adenocarcinoma in a population-based setting.

Methods
This population-based study based on the Finnish National Esophago-Gastric Cancer Cohort included all patients 18 years of age or older undergoing gastrectomy for gastric adenocarcinoma in Finland during 2005–2016. Logistic regression provided odds ratios (ORs) with 95% confidence intervals (CIs), both crude and adjusted for key confounders. Different types of complications were graded based on the Esophagectomy Complications Consensus Group definitions, and major complications were assessed by the Clavien-Dindo scale.

Results
This study analyzed 769 patients. Neoadjuvant chemotherapy did not increase major postoperative complications after gastrectomy for gastric cancer compared with upfront surgery (OR, 1.12; 95% CI 0.81–1.56). Furthermore, it did not increase pneumonia, anastomotic complications, wound complications, or other complications.

Conclusions
Neoadjuvant therapy is not associated with increased postoperative complications, reoperations, or short-term mortality compared with upfront surgery in gastric adenocarcinoma.
Association of the GHRd3 polymorphism with adult height and type 2 diabetes in a Saudi Arabian population from Jazan Province: A case-control study
Authors: Al-hakami Reham G. , Mashraqi Alaa Y. , Shannaq Rola Ali Atiah , Alshaikh Nalah A. , Kaabi Yahia A. 
Published: December 2023

Objectives: This study investigated the association of the GHRd3 polymorphism with height and type-2 diabetes mellitus (T2DM) in Saudi Arabia.
Methods: This case-control study included a total of 284 participants, divided into healthy controls (n = 142) and patients with T2DM (n = 142), recruited from Jazan University Hospital, southwest of Saudi Arabia in the period between January to September 2022. The GHRd3 polymorphism was genotyped using multiplex PCR. The correlation between height and genotypes was analyzed using one-way analysis of variance. The association between GHRd3 polymorphism and T2DM was assessed using logistic regression analysis.
Results: The data showed a significant difference between the means of heights associated with each GHRd3 genotype, flfl, fld3, and d3d3. Logistic regression analysis showed no association between GHRd3 variants and T2DM.
Conclusion: Homozygous GHRd3 polymorphism carriers, d3d3 genotype, were taller than fld3 or flfl carriers in our population. None of the GHRd3 variants were associated with T2DM. Thus, the GHRd3 polymorphism has growth-related actions with a minor contribution to T2DM. However, more studies with a larger sample size are required to confirm these findings.
doi: https://doi.org/10.12669/pjms.40.3.7686
How to cite this: Al-hakami RG, Mashraqi AY, Shannaq RAA, Kaabi YA. Association of the GHRd3 polymorphism with adult height and type 2 diabetes in a Saudi Arabian population from Jazan Province: A case-control study. Pak J Med Sci. 2024;40(3):308-312. doi: https://doi.org/10.12669/pjms.40.3.7686
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reviewing the current treatment approaches for vitiligo – analysis of literature
Authors: Ślusarczyk Daniel , Żmuda Bartłomiej , Jakubowska Wiktoria , Pisera Piotr , Kiełkowicz Aleksandra , Popińska Zuzanna , Pactwa Filip , Żuberek Michał 
Published: December 2023

Introduction:
Vitiligo is a relatively common systemic, idiopathic disease within the spectrum of pigmentary disorders. Clinically, it presents as depigmented patches on the skin, resulting from the loss or dysfunction of melanocytes. Despite not impacting life expectancy, vitiligo should not be perceived merely as a cosmetic defect, given its potential to burden daily life and the frequent experiences of stigmatization by patients.
Aim of the study:
The aim of this study was to summarize the existing knowledge regarding the treatment of vitiligo. The current treatments in practice, alongside potential new methods, were summarized and described.
Materials and methods:
The literature available in the PubMed database was reviewed using the following keywords: “Vitiligo”, “Vitiligo treatment”, “Vitiligo new treatment methods”, “Targeted therapies for vitiligo”.
Conclusions:
Vitiligo is a multifactorial and still inadequately understood disorder, leading to a lack of fully safe and effective treatment. As in the management of other diseases, there should be a push for highly personalized treatments for patients. This approach takes into account the differences among patients and ensures a better chance of a positive clinical response. To achieve this goal, it's necessary to explore new treatment methods and expand ongoing research efforts. Also, raising awareness of vitiligo is key to increasing acceptance, support and understanding for those affected by the disease.
Dietary eating patterns, dairy consumption, and anxiety: A systematic literature review
Authors: Movva Naimisha , Reichert Heidi , Hooda Naushin , Bylsma Lauren C. , Mitchell Meghan , Cohen Sarah S. 
Published: December 2023

Background
Nutrition affects both physical and mental health but evidence is mixed regarding potential associations between anxiety and diet, particularly dairy consumption. We conducted a systematic literature review (SLR) of dairy consumption and/or various dietary patterns and risk of anxiety.

Methods
Literature searches were conducted in PubMed and Embase. All study designs except case reports, small case series, and SLRs were considered for inclusion. Reference lists of previously published SLRs were reviewed for any relevant additional studies. Studies of populations without dairy sensitivities exploring the association between dietary patterns and/or dairy consumption and anxiety published through May 2022 were identified using predefined eligibility criteria. Study quality was determined using the Academy of Nutrition and Dietetics Quality Criteria Checklist.

Results
For this SLR, 132 studies were included; 80 were cross-sectional. Studies examined different dietary patterns (e.g., Mediterranean, gluten-free) and anxiety using various anxiety scales, with 19 studies specifically reporting on whole dairy consumption and anxiety. Dairy consumption was significantly associated with a lower risk of anxiety in 7 studies, while the remaining 12 studies showed no significant associations. Evidence was mixed for the association between various dietary patterns and anxiety, but more studies observed a lower risk of anxiety with greater adherence to “healthy” diets (e.g., Mediterranean, diet quality score, vegetarian/vegan) than a higher risk. Notable heterogeneity in study populations, time periods, geographical locations, dietary assessment methods, and anxiety scales was observed.

Conclusions
The results of this SLR suggest a potential link between diet including diary consumption and anxiety, but future studies, especially with longitudinal designs that measure diet and anxiety at several timepoints and comprehensively adjust for confounders, are needed to fully understand the relationship between diet and anxiety.
AXIOLOGICAL SIGNIFICANCE OF THE PRINCIPLE OF HUMANISM IN CRIMINAL LAW
Authors: Maximov A.G. 
Published: December 2023

Criminal law principles are the conceptual basis for the formation of an effective criminal law. In thecurrent Russian legislation, the principles have received normative consolidation, which is positive, theprinciples themselves in this regard should be the basis for the formation of criminal law norms. The authorof the work, using the integration method, studies the principle of humanism, both in general scientificand in a narrowly sectoral meaning, explores the axiological meaning of the principle of humanism. Theintegrative method in scientific research allows us to consider legal phenomena, processes, objects of legalregulation on the basis of methodological approaches of other sciences, not only the humanities, but alsousing mathematical methods, techniques of cybernetics. The article analyzes the criminal-legal significance of the principle of humanism from the perspective of the ratio of punishment and correction, as well as thepriorities of the implementation of the principle under consideration. The author identifies independentelements by means of which the axiological meaning of the principle of humanism is realized in modernRussian criminal law. Such elements include — content, structural, model.
Use of Over-the-Scope Clips in the Management of Refractory Postbanding Ulcer Bleed in a Patient After Liver Transplant
Authors: Sharma Disha , Bashir Hamidu Rukaiya , Viana Rodriguez Gracia , Canakis Andrew , Chatila Ahmed , Goldberg Eric 
Published: December 2023

ABSTRACT
Postbanding ulcer bleeds (PBUBs) are an uncommon complication of variceal band ligation. They are often treated with proton pump inhibitors in addition to endoscopic interventions such as epinephrine injections, hemostatic clips, electrothermal cautery, or further band ligation. Over-the-scope clips are being increasingly used for the management of acute nonvariceal upper gastrointestinal bleeds, but their use in the management of PBUBs has been reported only once before. We present a 24-year-old man with alcohol-associated decompensated cirrhosis with recurrent PBUB, despite multiple endoscopic interventions, transjugular intrahepatic portosystemic shunt, and liver transplant, treated successfully with an Ovesco clip.
Kosmiczne śmieci jako globalne wyzwanie ekologiczne
Authors: Sala Krzysztof 
Published: December 2023

Tematyka zanieczyszczenia powietrza, wody, gleby należy do najczęściej poruszanych zagadnień związanych z zagrożeniami ekologicznymi. Funkcjonuje ona również doskonale w powszechnej świadomości społecznej. Natomiast inna sytuacja zachodzi w przypadku zanieczyszczeń kosmicznych. Świadomość funkcjonowania kosmicznych śmieci i zagrożeń, jakie mogą sprawiać wśród społeczeństw jest nikła, a często wręcz nieobecna. Wynikać to może z małej popularyzacji wiedzy o problematyce kosmicznej w mediach, jak również z faktu, że zagrożenia tego typu pojawiły się stosunkowo niedawno. Liczba publikacji naukowych poruszających temat kosmicznych odpadków nie należy do obszernych. Luka poznawcza dotyczy także najnowszej wiedzy o zagrożeniach ze strony kosmicznych odpadów i sposobów ich eliminacji. Ujawniona luka poznawcza stanowi powód do poruszenia niniejszej tematyki. Celem niniejszej publikacji jest wykazanie, że kosmiczne śmieci niosą ze sobą niebagatelne zagrożenia ekologiczne na skalę globalną. Jednocześnie istnieją jednak sposoby skutecznego ograniczania tego zjawiska. Publikacja ma również pozytywnie wpłynąć na wzrost świadomości omawianej tematyki wśród społeczeństwa. Hipoteza badawcza brzmi: Istnieje poważny związek pomiędzy występowaniem kosmicznych odpadków a istotnym wpływem na stan środowiska naturalnego i ludzi w wymiarze ogólnoświatowym. W pracy dokonano omówienia pojęcia zanieczyszczenia kosmicznego, jego źródeł, początków, form oraz podziału. Szczególną uwagę poświęcono scharakteryzowaniu zagrożeń ekologicznych, jakie niesie ze sobą omawiane zjawisko. W publikacji ujawniono również przykłady działań mających na celu ograniczanie tego szkodliwego zjawiska. Artykuł powstał przy wykorzystaniu materiałów książkowych, czasopism, jak również informacji netograficznych.
Metodę badawczą zastosowaną w publikacji stanowi analiza danych zastanych i krytyka piśmiennicza. Wyniki badań pozytywnie weryfikują postawioną hipotezę.
Green Building Assessment Model for Historic Buildings of Turkey
Authors: Yetkin Elif Gizem , Koç İlhan 
Published: December 2023

Grave structures are architectural works reflecting the cultural accumulation, continuity and political power of societies.

In the context of sustainability, while "green building" certification systems are developing in building productions in the world, new guidelines are also being created. Of course, new guidelines are also being developed on the certification as green buildings within the scope of the protection and restoration of historical buildings that should be specially considered. In this study, it is aimed to create a model that will allow the historical buildings in Turkey to be evaluated in the context of “the green building” concept. With this model, it is considered that historical building conservation practices will contribute positively to the works of restorers in making those heritage sites more environmentally friendly and sustainable.

For the model designed to evaluate historical buildings within the scope of green buildings, historical buildings were handled under 3 groups: a) 1st Group Historical Buildings, b) 2nd Group Historical Buildings and c) Reconstructed Historical Buildings. As creating the designed model, GBC-Italy system criteria were taken as the basis. The criteria were carried out by conducting a questionnaire with experts in this field. Importance of the relevant evaluation criteria in the scoring system were determined by using the AHP method. As a result of the analyzes and calculations, the accuracy of the scoring was confirmed.

As historical buildings are evaluated according to the conditions of their periods, it is obvious that they are sustainable buildings. Naturally, nowadays to be able to preserve historical buildings for the future generations in a proper way is usually ensured by giving them a new function. The requirements of the new functions given to create the necessary equipment to provide today's comfort conditions in historical buildings naturally change the sustainable characteristics of the historical heritage. This evaluation system, designed to preserve the green building characteristics of historical buildings and to ensure their sustainability with their new functions, will be an important guide.
On maximality of some solvable and locally nilpotent subalgebras of the Lie algebra $W_n(K)$
Authors: Efimov D.I. , Sydorov M.S. , Sysak K.Ya. 
Published: December 2023

Let $K$ be an algebraically closed field of characteristic zero, $P_n=K[x_1,\ldots ,x_n]$ the polynomial ring, and $W_n(K)$ the Lie algebra of all $K$-derivations on $P_n$. One of the most important subalgebras of $W_n(K)$ is the triangular subalgebra $u_n(K) = P_0\partial_1+\cdots+P_{n-1}\partial_n$, where $\partial_i:=\partial/\partial x_i$ are partial derivatives on $P_n$ and $P_0=K.$ This subalgebra consists of locally nilpotent derivations on $P_n.$ Such derivations define automorphisms of the ring $P_n$ and were studied by many authors. The subalgebra $u_n(K) $ is contained in another interesting subalgebra $s_n(K)=(P_0+x_1P_0)\partial_1+\cdots +(P_{n-1}+x_nP_{n-1})\partial_n,$ which is solvable of the derived length $ 2n$ that is the maximum derived length of solvable subalgebras of $W_n(K).$ It is proved that $u_n(K)$ is a maximal locally nilpotent subalgebra and $s_n(K)$ is a maximal solvable subalgebra of the Lie algebra $W_n(K)$.