bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Haemato‐Oncology Frailty (HOF) score to assess frailty in lymphoma
Authors: Ramdany Hena , Lofaro Thomas , Deplano Simona 
Published: December 2023

AbstractMorbidity and mortality during chemotherapy in older adults with haematological malignancy can be unpredictable. The Haemato‐Oncology Frailty (HOF) score was previously found to predict outcomes in a cohort of patients with plasma cell myeloma. In this study, we assess its utility in assessing frailty in patients with lymphoma, and compare its performance to that of two other frailty scores. The HOF score was able to predict progression‐free survival in this population, and was also shown to have potential in assessing the dynamism of frailty during chemotherapy. It performed well when compared to the Charlson Comorbidity Index (CCI) score and the Haematopoietic Cell Transplantation‐Specific Comorbidity Index (HCTCI), although the study was not powered to assess for non‐inferiority. The HOF score is a new score with the potential for application in different haematological malignancies.
Aspen recovery in northern Yellowstone: A comment on Brice et al. (2021)
Authors: Painter Luke E. , Beschta Robert L. , Ripple William J. 
Published: December 2023

AbstractAspen sapling recruitment increased as browsing by elk decreased, following the 1995–96 reintroduction of wolves in Yellowstone National Park. We address claims by Brice et al. (2021) that previous studies exaggerated recent aspen recovery. We conclude that their results actually supported previous work showing a trophic cascade benefiting aspen.
Thermal tolerance in Pacific salmon: A systematic review of species, populations, life stages and methodologies
Authors: Mayer Noa B. , Hinch Scott G. , Eliason Erika J. 
Published: December 2023

AbstractAquatic systems are warming and exceeding upper thermal limits (UTLs) for many fish species, yet understanding how they inform resilience to climate change is challenging. Using Pacific salmon (Oncorhynchus spp.) as a model, we conducted a systematic review involving 168 papers investigating UTL in five species. We found considerable variation in UTL among species, within species and across life stages; largely attributed to methodological approaches (e.g. CTmax/UILT, Aerobic/Cardiac Scope, Thermal Migration Barriers, Rearing Mortality, Thermal Preference/Avoidance). Given that each method has strengths and weaknesses owing to logistics, time scale and ecological realism, we offer a new framework for assessing vulnerability to warming that stresses the importance of considering UTL metrics in the context of intended use (i.e. the development of management guidelines, projections of future persistence and survival) and what aspect (physiological or behavioural) of thermal response a metric investigates. Comparing studies with identical UTL approaches revealed that within species, UTL was higher for populations historically encountering higher temperatures—suggesting local thermal adaptation. Within populations, UTL differed across the lifecycle, being highest in fry and lowest in embryo and migrating adults, but this was not universal. For spawning Pacific salmon, UTL has not been assessed and few studies have examined estuarine and marine stages. Ultimately, this data gap limits the life‐history thermal perspectives that can be drawn and may indicate a broader gap for all fishes, given that Pacific salmon are among the most well‐studied species. Our framework illustrates the inherent and methodological inconsistencies in UTL and offers a guide for how thermal limits can best be used to assess the warming tolerance and vulnerability of fishes.
Co‐occurring trajectory of housing stability and parenting stress with child behavior problems: A randomized trial of a housing intervention for young mothers experiencing homelessness
Authors: Zhang Jing , Wu Qiong , Feng Xin , Ford Jodi , Famelia Ruri , Slesnick Natasha 
Published: December 2023

AbstractThis study examined the effects of an integrative housing intervention (Ecologically Based Treatment, EBT – independent housing and supportive services) on the co‐occurring pattern of housing stability and parenting stress among a sample of substance‐using mothers who experience homelessness and have young children in their care. The association between the co‐occurring patterns of housing stability and parenting stress and child internalizing and externalizing behaviors was also examined. Mothers were randomized to one of the three conditions: EBT (n = 80), Housing‐only (HOU; n = 80), or Services as Usual (SAU; n = 80). Follow‐up assessments were completed at 3‐, 6‐, 9‐, and 12‐months post‐baseline. The dual‐trajectory latent class growth analyses identified five subgroups of co‐occurring patterns: low‐greatly improved housing paired with moderate‐improved parenting stress, low‐greatly improved housing paired with high‐improved parenting stress, low‐moderately improved housing paired with moderate‐static parenting stress, low‐worse housing paired with moderate‐improved parenting stress, and low‐worse housing paired with high‐static parenting stress. Findings showed that EBT was more effective in improving housing stability and reducing parenting stress compared to HOU and SAU conditions, and further, HOU was more effective than SAU. Additionally, children whose mothers reported increased housing stability together with improved parenting stress had lower levels of internalizing and externalizing behaviors. The findings provide support to the efficacy of EBT in increasing housing stability and reducing parenting stress. The observed improvements subsequently benefited children's behavioral outcomes.
“Working in the emergency department is not a job; it's like a war” A narrative inquiry and interpretive phenomenology of the violence experienced by emergency nurses in Turkey
Authors: Bilgin Aylin , Kovanci Mustafa Sabri , Öcalan Sinem 
Published: December 2023

AbstractAimsThis study aims to reveal the violent experiences of nurses working in the emergency department and the meanings they attribute to them.MethodsThis research was conducted as narrative inquiry and interpretive phenomenology and recruited 15 nurses. Interviews with nurses actively working in the emergency department and who had been exposed to violence by patients or their relatives were conducted with a semi‐structured interview form. The consolidated criteria for reporting qualitative research (COREQ) checklist was used.ResultsIn the study, three themes were determined (1) Unpredictable event, (2) Interminable effects of violence, and (3) Like a bottomless pit. With seven sub‐themes.ConclusionsThis study underlined that violence applied to nurses by patients or relatives of patients in the emergency department is an unexpected situation that causes negative emotions. Violence affects all aspects of life and limits communication with the patient. Coping with a violent situation is challenging for nurses, and they demand support from the management.
Real world evidence of enfortumab vedotin in patients with advanced urothelial cancer: A multicenter observational study
Authors: Fukuokaya Wataru , Koike Yuhei , Yata Yuji , Komura Kazumasa , Uchimoto Taizo , Tsujino Takuya , Saruta Masanobu , Takahara Kiyoshi , Fujita Kazutoshi , Minami Takafumi , Adachi Takahiro , Hirasawa Yosuke , Hashimoto Takeshi , Ohno Yoshio , Uemura Hirotsugu , Shiroki Ryoichi , Azuma Haruhito , Kimura Takahiro 
Published: December 2023

ObjectivesTo explore the characteristics of patients and assess the effectiveness of enfortumab vedotin (EV) in those with treatment‐resistant advanced urothelial cancer in a real‐world setting.Patients and MethodsA multicenter observational study was conducted on 103 evaluable patients with advanced urothelial cancer who received EV. Outcomes were assessed by radiographic response, progression‐free survival (PFS), and overall survival (OS), with treatment‐related adverse events (trAEs). Radiographic response was assessed using Response Evaluation Criteria in Solid Tumors version 1.1, while trAEs were studied in line with Common Terminology Criteria for Adverse Events version 5.0.ResultsThe median follow‐up was 8.9 months (range, 0.1–16.4). The observed objective response rate was 50.5%. The median PFS was 6.0 months (95% CI: 4.7–9.8), and the median OS was 14.5 months (95% CI: 12.4–not reached). Out of the 103 patients, 19 (18.4%) had an Eastern Cooperative Oncology Group performance status of 2 or more, 14 (14.7%) had an non‐urothelial carcinoma histology, and 40 (38.3%) had at least one pre‐existing comorbidity. There were 26 (25.2%) patients who reported 49 trAEs, with 9 (18.3%) being grade 3 or higher. The most common trAEs included rash, occurring in 18.4%.ConclusionsThis study describes the characteristics and outcomes of patients with previously treated advanced urothelial cancer receiving EV. The findings demonstrate that EV showed robust anti‐tumor activity and had manageable safety profiles outside the clinical trial setting.
Improved clinical effectiveness of adalimumab when initiated with clindamycin and rifampicin in hidradenitis suppurativa
Authors: Aarts P. , van Huijstee J. C. , van der Zee H. H. , van Straalen K. R. , Prens E. P. 
Published: December 2023

AbstractBackgroundAdalimumab monotherapy for hidradenitis suppurativa (HS) is often insufficient with a maximum clinical efficacy of 60% in Hidradenitis Suppurativa Clinical Response (HiSCR) and limited effect on draining tunnels. Data suggest that adalimumab therapy could be improved by concomitant antibiotics.ObjectiveTo compare the clinical effectiveness of adalimumab with clindamycin and rifampicin versus adalimumab monotherapy after 12 weeks.MethodsThis retrospective study included patients who started adalimumab with additional clindamycin and rifampicin and patients treated with adalimumab monotherapy, matched on sex and refined Hurley score. The primary outcome measure was the difference in change in the International Hidradenitis Suppurativa Severity Score System (IHS4) at 12 weeks.ResultsIn total, 62 patients were included in the combination therapy group (n = 31) and adalimumab monotherapy group (n = 31), showing comparable IHS4 scores; 32.5 versus 29, p = 0.87 at baseline respectively. The combination therapy demonstrated greater clinical effectiveness expressed in median IHS4 improvement (−20 vs. −9, p < 0.001), IHS4‐55 (74% vs. 36%, p = 0.002), median draining tunnel reduction (−4 vs. −2, p < 0.001) and pain response (47% vs. 27%, p = 0.02).ConclusionAdalimumab initiated with clindamycin and rifampicin shows greater clinical effectiveness than adalimumab monotherapy. An important difference in effect was observed in the decrease of draining tunnels, addressing a serious limitation of adalimumab monotherapy.
Routines and child development: A systematic review
Authors: Selman Saliha B. , Dilworth‐Bart Janean E. 
Published: December 2023

AbstractResearch has shown the importance of routines for optimal child development. A systematic review can offer a detailed overview of the evidence linking routines to child outcomes, particularly in high‐risk settings. This review aimed to elucidate the association between daily routines and child development and to pinpoint the protective role of routines in high‐risk environments. A search of PubMed and PsycINFO databases yielded literature from 1950 to June 2020. Out of 4297 initial hits, 170 studies met the selection criteria. Findings mainly indicate that routines are associated with positive developmental outcomes in children, covering cognitive, self‐regulation, social–emotional, academic skills, and overall mental and physical health. The results also underline the protective power of routines in challenging environments. The study suggests possible mechanisms through which routines influence child outcomes and recommends avenues for future research, supporting evidence‐based strategies to encourage parental use of routines.
Prophylactic common iliac artery temporary clamping versus balloon occlusion for management of placenta accreta spectrum disorders: A prospective clinical trial
Authors: Bessar Ahmed Awad , Heraiz Ahmed Ismail , Ibrahim Ahmed Gamil , Salem Mahmoud M. A. , Zaitoun Mohamed Moustafa , Aboelfateh Amr Mostafa Kamel , Gad Abdalla Hassan 
Published: December 2023

AbstractObjectiveThe present study aims to compare prophylactic common iliac artery (CIA) temporary clamping and preoperative balloon occlusion for managing placenta accreta spectrum (PAS) disorders.Study DesignBetween January 2019 and June 2020, 46 patients with PAS disorders were included. Of them, 26 patients were offered CIA balloon occlusion (Group A), while temporary CIA clamping was done for the other 20 patients (Group B). Primary outcomes were procedure‐related complications, and secondary outcomes included intraoperative and postoperative complications, reoperation rates, total procedure time, blood loss, and amount of blood transfusion.ResultsBlood loss was statistically non‐significant higher in group B than in group A (p‐value = 0.143). Only one patient in group A and three in group B needed reoperation. The bleeding continued for a mean of 1.6 days in group A and 1.7 days in group B, with non‐significant statistical differences between both groups p value = 0.71. Nine patients in group A (34.6%) and four in group B (20%) required ICU admission. The mean Apgar score was 7 and 6.6 in babies of group A and group B patients, respectively. The median number of allogeneic blood transfusions performed was two in patients in group A and 1 in group B (p‐value = 0.001).ConclusionBoth techniques offer good choices for patients with PAS to decrease mortality and morbidity rates. The selection of a better technique depends on institutional references and physicians' experience.
Rituximab use in paediatric nephrology practice in Türkiye: TRTX
Authors: Ünal Ahmet , Leventoğlu Emre , Bakkaloğlu Sevcan A. 
Published: December 2023

AbstractAimRituximab (RTX) is a genetically engineered chimeric monoclonal antibody which binds directly to CD20 antigen and mediates inhibition of B cell development. Although RTX has been widely used in paediatric nephrology, there is no routine protocol for its use. In this study, paediatric nephrologists in Türkiye were asked to fill out a questionnaire to understand their practice in using RTX. This study aimed to determine common practices and clarify the uncertainties regarding the use of RTX in paediatric nephrology.MethodsThis was a nationwide, multicenter, retrospective cohort study based on data evaluating the use of RTX in paediatric nephrology practice. An online questionnaire was sent to all paediatric nephrology centers in Türkiye. The questionnaire forms included information about how many patients in total applied RTX treatment, for which indications they use RTX, and whether they made any preparations before using RTX.ResultsAccording to this survey on RTX use in Türkiye, paediatric nephrologists use it most commonly in SSNS and followed by SRNS, ABMR, SLE and AAV, respectively. Dosing was highly standard but there is significant heterogeneity in pre‐exposure tests and patient monitoring in the clinical practice of RTX. Also, the rate of encountering RTX‐related allergic and infectious side effects at least once during the professional experience of our physicians can be quite high.ConclusionThere is an increasing need for the preparation of a guideline on the indications for RTX use for each diagnosis, posology, and the practices to be performed before and after infusion.image
Comprehensive physiological, transcriptomic, and metabolomic analysis of the key metabolic pathways in millet seedling adaptation to drought stress
Authors: Cui Xiaomeng , Wang Bianyin , Chen Zhaoyang , Guo Jixun , Zhang Tao , Zhang Wenying , Shi Lianxuan 
Published: December 2023

AbstractDrought is one of the leading environmental constraints that affect the growth and development of plants and, ultimately, their yield and quality. Foxtail millet (Setaria italica) is a natural stress‐resistant plant and an ideal model for studying plant drought resistance. In this study, two varieties of foxtail millet with different levels of drought resistance were used as the experimental material. The soil weighing method was used to simulate drought stress, and the differences in growth, photosynthetic physiology, metabolite metabolism, and gene transcriptional expression under drought stress were compared and analyzed. We aimed to determine the physiological and key metabolic regulation pathways of the drought‐tolerant millet in resistance to drought stress. The results showed that drought‐tolerant millet exhibited relatively stable growth and photosynthetic parameters under drought stress while maintaining a relatively stable level of photosynthetic pigments. The metabolomic, transcriptomic, and gene co‐expression network analysis confirmed that the key to adaptation to drought by millet was to enhance lignin metabolism, promote the metabolism of fatty acids to be transformed into cutin and wax, and improve ascorbic acid circulation. These findings provided new insights into the metabolic regulatory network of millet adaptation to drought stress.
A Billion‐Euro Industry? (De‐)territorialisation Processes of Norway's Seaweed Farming Assemblage
Authors: Albrecht Moritz 
Published: December 2023

AbstractSeaweed farming is a rising sector in European policy narratives and is increasingly integrated in coastal countries' bioeconomy strategies. Norway aims to lead this European ‘Seaweed Revolution’. Envisioned as a ‘billion‐euro industry’, its development is in its infancy yet contains ambitions for upscaling and socio‐economic credentials that promote it as a sector for sustainable finance and investments. Through assemblage conceptualisation, the paper unfolds the relations that connect the fluid materialities of seaweed with ambitious business plans, coastal localities, calls for upscaling, complex markets and assesses the trajectories potentials for sector development. Instead of forecasting the future of seaweed farming in Norway, it displays how the sociospatial complexities of the Norwegian seaweed farming assemblages' components enable or disperse currently dominant and optimistic sectoral narratives, providing a critical window to highlight the underlying and partially contradictory processes that shape the development trajectories of a sector promoted as a beacon of sustainable transformation.
Healing rates and outcomes following closed transmetatarsal amputations: A systematic review and random effects meta‐analysis of proportions
Authors: Coye Tyler , Ansert Elizabeth , Suludere Mehmet A. , Chung Jayer , Kang Gu Eon , Lavery Lawrence A. 
Published: December 2023

AbstractTransmetatarsal amputation (TMA) is a common surgical procedure for addressing severe forefoot pathologies, such as peripheral vascular disease and diabetic foot infections. Variability in research methodologies and findings within the existing literature has hindered a comprehensive understanding of healing rates and complications following TMA. This meta‐analysis and systematic review aims to consolidate available evidence, synthesising data from multiple studies to assess healing rates and complications associated with closed TMA procedures. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines, a systematic search of Medline, Embase, and Cochrane databases was conducted for articles published from January 1st, 1988, to June 1st, 2023. Inclusion criteria comprised studies reporting healing rates in non‐traumatic transmetatarsal amputation patients with more than 10 participants, excluding open TMAs. Two independent reviewers selected relevant studies, with disagreements resolved through discussion. Data extracted from eligible studies included patient demographics, healing rates, complications, and study quality. Among 22 studies encompassing 1569 transmetatarsal amputations, the pooled healing rate was 67.3%. Major amputation rates ranged from 0% to 55.6%, with a random‐effects pooled rate of 23.9%. Revision rates varied from 0% to 36.4%, resulting in a pooled rate of 14.8%. 30‐day mortality ranged from 0% to 9%, with a fixed‐effects pooled rate of 2.6%. Post‐operative infection rates ranged from 3.0% to 30.7%, yielding a random‐effects pooled rate of 16.7%. Dehiscence rates ranged from 1.7% to 60.0%, resulting in a random‐effects pooled rate of 28.8%. Future studies should aim for standardised reporting and assess the physiological and treatment factors influencing healing and complications.
Experimental Analysis of Additively Manufactured Latticework Coupons
Authors: Castelli Niccolò , Sandri Umberto , Picchi Alessio , Facchini Bruno , Morante Francesco , Cubeda Simone 
Published: December 2023

Abstract
The capabilities and the precision of additive manufacturing processes have been tremendously increased in the last years, and this trend is not expected to be close to an end. Researchers, in the gas turbine industry, are focusing on the technology implementation on cooling systems. The aim of the present work is to investigate the performances of eight different geometries in order to exploit the cooling potential of some challenging latticework schemes with respect to traditional ones such as smooth channel, dimples, and pin fins. Test coupons consisting of those cooling structures embedded inside a rectangular cooling channel with dimensions of 56 mm width, 5 mm height, and 68 mm length were fabricated by means of direct metal laser melting technique. Since an aim of the present work is to evaluate the shape deformation associated with this additive process, the results of the CT scan imaging technique are presented. The performances are characterized both in terms of averaged heat transfer and friction factor values inside the test coupons by means of steady-state technique with a constant wall temperature boundary condition. The investigated flow Reynolds numbers range from 18, 000 to 40, 000. These values allow the authors to provide a deeper understanding of the latticework structures performances at Reynolds numbers beyond the range typically investigated in the literature. An efficiency index is employed to compare the performances of each geometry. Although the obtained results reveal that none of the tested geometries outperforms the other ones, the latticework arrangements show a heat transfer enhancement with respect to a porosity decrease. In addition, the good capability in terms of heat transfer of the lattice structures measured in the present work suggests the use of such technologies for twofold optimization process based on mechanical resistance and heat transfer characteristics.
Complete genome sequences of
Streptomyces griseus
phages Spelly and Phredrick
Authors: Stamm Joyce , Merkle Julie A. , Abernathy Ava , Ackerman Elizabeth , Brown John , Harris Abbey , Hoffman Kayli , Hoskins Ashleigh , Jahn Abbie , Jones Nathan , Kitch Ashley , Mathavan Nandini , Rose Nat , Taylor Joey 
Published: December 2023

ABSTRACT

We present the complete genome sequences of two viruses with siphovirus morphology, isolated from soils collected in Southwestern Indiana using the host
Streptomyces griseus
. Spelly is a BE2 cluster phage with a 131,347-bp genome. Phredrick is a BK1 cluster phage with a 128,873-bp genome.