bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto‐optical nanoparticle
Authors: Sosnovik David E. , Schellenberger Eyk A. , Nahrendorf Matthias , Novikov Mikhail S. , Matsui Takashi , Dai George , Reynolds Fred , Grazette Luanda , Rosenzweig Anthony , Weissleder Ralph , Josephson Lee 
Published: August 2005

AbstractThe ability to image cardiomyocyte apoptosis in vivo with high‐resolution MRI could facilitate the development of novel cardioprotective therapies. The sensitivity of the novel nanoparticle AnxCLIO‐Cy5.5 for cardiomyocyte apoptosis was thus compared in vitro to that of annexin V‐FITC and showed a high degree of colocalization. MRI was then performed, following transient coronary artery (LAD) occlusion, in five mice given AnxCLIO‐Cy5.5 and in four mice given an identical dose (2 mg Fe/kg) of CLIO‐Cy5.5. MR signal intensity and myocardial T2* were evaluated, in vivo, in hypokinetic regions of myocardium in the LAD distribution. Ex vivo fluorescence imaging was performed to confirm the in vivo findings. Myocardial T2* was significantly lower in the mice given AnxCLIO‐Cy5.5 (8.1 versus 13.2 ms, P < 0.01), and fluorescence target to background ratio was significantly higher (2.1 versus 1.1, P < 0.01). This study thus demonstrates the feasibility of obtaining high‐resolution MR images of cardiomyocyte apoptosis in vivo with the novel nanoparticle, AnxCLIO‐Cy5.5. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.
Solitary bone plasmocytoma of the spine in an adolescent
Authors: Dumesnil C. , Schneider P. , Dolgopolov I. , Radi S. , Leluyer B. , Vannier J.P. 
Published: August 2005

AbstractSolitary plasmocytoma (SP) represent only about 5% of plasma cell neoplasia. Most patients have generalized disease, that is, multiple myeloma (MM). Solitary bone plasmocytoma (SBP) is a localized plasma cell tumor and is a very rare disease in young patients. We reported here, a case of SPB in a 14‐year‐old girl with a 10‐year disease‐free survival after an aggressive treatment. The relationship of SBP to MM continues to be controversial. Recommendations on the diagnosis and management of SBP in adults, based on a literature search and consensus of expert opinion, were recently published on behalf of the Guidelines Working Group of the United Kingdom Myeloma Forum 1. MRI of the spine is necessary to assess local disease. Radiotherapy with doses of 45–50 Gy is the recommended treatment and gives a high rate of local control (83–96%). Chemotherapy remains controversial in contrast to MM, in which intensive chemotherapy with autologous bone marrow transplantation (ABMT) is widely accepted. At the present time, considering the good prognosis of patients with a normal MRI at diagnosis and a complete disappearance of the M protein after radiotherapy, we believe that ABMT should be reserved for relapse or primary therapeutic failure. Pediatr Blood Cancer 2006;47:335–338. © 2005 Wiley‐Liss, Inc.
How low is too low? Use of cluster analysis to define low levels of mercaptopurine metabolites
Authors: Traore Fatoumata , O'Riordan Mary Ann , Myers Carolyn , Groth Karen , Hoff Ahna , Angiolillo Anne , Rheingold Susan , Drotar Dennis , Kodish Eric 
Published: August 2005

AbstractBackgroundTo group patients receiving treatment for acute lymphoblastic leukemia (ALL) according to their oral mercaptopurine (6‐MP) metabolite levels and to establish cut‐off points to screen for potential poor clinical outcome.ProcedureMethodological study using 6‐MP metabolite levels from 48 adolescent ALL patients enrolled in a multicenter adherence study. Cluster analysis was the primary analytical technique. We used two validation methods (a split‐sampling and a simulation technique) for validating the results.ResultsFour clusters were retained in our initial analysis using our first group of patients (n = 27). Three clusters (labeled 1, 2, and 4) exhibited the expected negative correlation between the two metabolites, that is, “high” values of one were associated with “low” values of the other. One cluster (labeled 3) had “low” levels for both TGN and MMP. Five of the 27 adolescents had their 6‐MP “held” during the study. Post‐hoc examination of the results revealed that all five grouped in Cluster 3 during the time that their medications were stopped, but grouped in other clusters at other times. The median ANC was highest in Cluster 3, consistent with low therapeutic drug levels. Parameters were reproducible with both validation methods. Values below the respective 75th centile for both TGN and MMP in Cluster 3 for the complete sample (n = 48) are suggested as representing a potentially higher risk for relapse.ConclusionsThis study provides an objective method for identifying patients at risk for treatment failure due to suboptimal 6‐MP therapy; the clinical significance of this approach should be examined in future studies. © 2005 Wiley‐Liss, Inc.
Pulmonary function in long‐term survivors of pediatric hematopoietic cell transplantation
Authors: Hoffmeister Paul A. , Madtes David K. , Storer Barry E. , Sanders Jean E. 
Published: August 2005

AbstractBackgroundThe purpose of this study was to determine the prevalence of pulmonary dysfunction in pediatric hematopoietic cell transplant (HCT) survivors and to identify associated risk factors.ProcedureIn a cross‐sectional study, patients surviving at least 5 years after pediatric HCT were requested to undergo pulmonary function testing (PFT). Risk factors for restrictive lung disease (RLD) and obstructive lung disease (OLD) were analyzed using multivariate analysis.ResultsAmong 472 patients contacted, 260 (55%) participated and 215 were selected for analysis. These patients were transplanted at a median age of 8.3 (0.3–18.0) years; 175 for hematologic malignancies and 40 for non‐malignant diseases. The preparative regimens for 133 patients included fractionated TBI (FTBI), 29 single‐fraction TBI (SFTBI), and 53 non‐TBI regimens. PFT was performed at a median of 10 (5.0–27.5) years after HCT. Forty percent of patients had either RLD or OLD (28% RLD, 9% OLD, 3% mixed RLD/OLD) and at least 15% had an isolated low‐DLCO. Moderate‐to‐severe impairment was present in 45% of patients with RLD or OLD. In multivariate analysis, risk factors associated with RLD included transplant regimen, transplant diagnosis, scleroderma/contracture, and donor relation. Patients treated with SFTBI had the highest risk of RLD. Risk factors for OLD included chronic graft‐versus‐host disease, transplant regimen, and time after HCT. Patients surviving 20 or more years after HCT had the highest risk of OLD.ConclusionsFifty‐five percent of long‐term pediatric HCT survivors had pulmonary dysfunction. These findings stress the need for long‐term follow‐up to detect pulmonary dysfunction. Pediatr Blood Cancer 2006; 47:594–606. © 2005 Wiley‐Liss, Inc.
Natural history of thyroid nodules in survivors of pediatric Hodgkin lymphoma
Authors: Metzger Monika L. , Howard Scott C. , Hudson Melissa M. , Gow Kenneth W. , Li Chin‐Shang , Krasin Matthew J. , Merchant Thomas , Kun Larry , Shelso John , Pui Ching‐Hon , Shochat Stephen J. , McCarville M. Beth 
Published: August 2005

AbstractBackgroundSurvivors of Hodgkin lymphoma and other patients who receive neck irradiation are at increased risk of thyroid cancer. Ultrasonography provides an inexpensive and non‐invasive method of thyroid screening, but the clinical significance of thyroid nodules detected by ultrasound screening is uncertain.ProcedureWe reviewed the demographics, clinical characteristics, method of detection, and outcome of patients who developed thyroid nodules after treatment for pediatric Hodgkin lymphoma at our institution. One radiologist reviewed all imaging studies.ResultsSixty‐seven children treated for Hodgkin lymphoma from 1962 to 2001 developed thyroid nodules. The study group represented 9,024 person‐years of follow‐up after the diagnosis of Hodgkin lymphoma and 581 person‐years after diagnosis of a thyroid nodule. A median of 10.5 years (range, 0.2–24.8 years) elapsed between the diagnoses of Hodgkin lymphoma and thyroid nodule(s). All but one patient had received neck irradiation for Hodgkin lymphoma, with a median thyroid radiation dose of 35 Gy (range, 12–45 Gy). Thyroid nodules were found to be malignant in seven patients (10%), at a median of 16.2 years (range, 8.4–23.7 years) after diagnosis of Hodgkin lymphoma. Only one malignancy was found through screening ultrasonography. All patients with thyroid cancer remained disease‐free at 0.4–16.2 years of follow‐up.ConclusionsThyroid nodules are common in Hodgkin lymphoma survivors treated with neck irradiation, but the majority of these lesions have an indolent clinical course and do not undergo malignant transformation. Only patients with a palpable mass or clinical symptoms need more extensive evaluation, including Doppler‐flow ultrasonography and fine‐needle aspiration. © 2005 Wiley‐Liss, Inc.
Inorganic–organic hybrids involving poly(ε‐caprolactone) and silica network: Hydrogen‐bonding interactions and isothermal crystallization kinetics
Authors: Nie Kangming , Zheng Sixun , Lu Fei , Zhu Qingren 
Published: August 2005

AbstractInorganic–organic hybrids mediated by hydrogen‐bonding interactions involving silicon oxide network and poly(ε‐caprolactone) (PCL) were prepared via an in situ sol–gel process of tetraethoxysilane in the presence of PCL. Fourier transform infrared spectroscopy indicated that there were hydrogen‐bonding interactions between carbonyls of PCL and silanol hydroxyls that were formed by incomplete polycondensation in the sol–gel process. In terms of the frequency shift of the hydroxyl stretching vibration bands, it is concluded that the strength of the interassociation between PCL and silicon oxide networks is weaker than that of the self‐association in the control silica network. The phenomenon of equilibrium melting point depression was observed for the PCL/silica system. The hybridization of PCL with silica network causes a considerable increase in the overall crystallization rate and dramatically influences the mechanism of nucleation and growth of the PCL crystallization. The analysis of isothermal crystallization kinetic data according to the Hoffman‐Lauritzen theory shows that with increasing silica content in the hybrids, the surface energy of extremity surfaces increases dramatically for the hybrids. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2594–2603, 2005
Sorption, degradation and leaching of the fungicide iprodione in a golf green under Scandinavian conditions: measurements, modelling and risk assessment
Authors: Strömqvist Johan , Jarvis Nicholas 
Published: August 2005

AbstractIn cold climates, fungicides are used on golf greens to prevent snow mould causing serious damage to the turf. However, fungicide residues have been detected in runoff from golf courses, which may lead to restrictions on use. There is therefore an urgent need to improve understanding of the processes affecting leaching of fungicides from turfgrass systems to allow identification of green construction and management practices that minimize environmental impacts. In this study we monitored the leaching of the fungicide iprodione in a putting green. Sorption and degradation of iprodione was measured in batch and incubation experiments, and the simulation model MACRO was used as a risk assessment tool. Degradation of iprodione was bi‐phasic, with a rapid initial phase (half‐life 17 h) caused by enhanced biodegradation. Degradation rates slowed considerably after 5 days, with half‐lives of up to 38 days. Sorption of iprodione was linear, with a Koc value of ca 400 cm3 g−1. MACRO reasonably accurately matched measured drainflows and concentrations of iprodione in soil and drainflow. However, peak concentrations in drainage were underestimated, which was attributed to preferential finger flow due to water repellency. The results also showed the importance of the organic matter content in the green root zone in reducing leaching. It was concluded that, with ‘reasonable worst‐case’ use, losses of iprodione from greens can occur at concentrations exceeding water quality limits for aquatic ecosystems. Snow mould problems should be tackled by adopting green root zone mixes that minimize leaching and ‘best management practices’ that would avoid the need for intensive prophylactic use of fungicides. Copyright © 2005 Society of Chemical Industry
First‐trimester ultrasound diagnosis in a recurrent case of Walker–Warburg syndrome
Authors: Blin G. , Rabbé A. , Ansquer Y. , Meghdiche S. , Floch‐Tudal C. , Mandelbrot L. 
Published: August 2005

AbstractWe report on two siblings with Walker–Warburg syndrome (WWS) born to a consanguineous couple. In the index case, the second‐trimester scan showed ventricular dilatation and we diagnosed WWS after observing retinal detachment at 26 weeks' gestation and lissencephaly by 32 weeks' gestation in addition to hypoplasia of the cerebellar vermis. The second case was first suspected at 12 weeks' gestation, when we observed a 2.8‐mm nuchal translucency and an unusually large hindbrain vesicle. By 14 weeks' gestation, the lateral ventricles were clearly enlarged (12–13 mm), at 16 weeks' gestation the vitreous chamber appeared to be hyperechogenic, and by 17 weeks' gestation hydrocephalus was evident. The couple chose to continue the pregnancy, and during the third trimester lissencephaly, major hydrocephalus and polyhydramnios developed.Serial ultrasound examination should be offered to a family with a history of WWS and therefore a 1 in 4 risk of recurrence. In some cases, recurrence can be suspected as early as the first trimester, however the diagnosis cannot be excluded on the basis of normal ultrasound appearance until later in pregnancy. Copyright © 2005 ISUOG. Published by John Wiley & Sons, Ltd.
Fetal intracranial hemorrhage (fetal stroke): does grade matter?
Authors: Elchalal U. , Yagel S. , Gomori J. M. , Porat S. , Beni‐Adani L. , Yanai N. , Nadjari M. 
Published: August 2005

AbstractObjectiveTo determine if the severity of antenatally diagnosed hemorrhagic fetal brain insults and fetal stroke detected by ultrasound and magnetic resonance imaging (MRI) predicts postnatal neurodevelopmental prognosis.MethodsThe in‐utero presentation and postnatal neurodevelopmental outcome of sonographically detected subdural hematoma or fetal stroke presenting as intraventricular hemorrhage (IVH) or intraparenchymal brain hemorrhage were investigated.ResultsOf 33 fetuses diagnosed with hemorrhagic brain lesions, 17 were electively terminated and two suffered intrauterine fetal demise. Thirteen were liveborn, seven by Cesarean delivery and six by spontaneous vaginal delivery. One case was lost to follow‐up. Eight neonates had moderate to severe neurological deficit by a mean age of 35 (range, 6–96) months. One died at 2 months of age. These nine were diagnosed with Grade III–IV IVH in utero. Four neonates had normal neurological outcome by a mean age of 41 (range, 30–48) months; these four were diagnosed with subdural hematoma (n = 1) or Grade I–II IVH (n = 3) in utero. Fourteen cases were followed up with MRI, which confirmed ultrasound findings in 10 (71%) cases. In three (21%) cases MRI diagnosis was more accurate and the severity of grading was greater than that obtained on ultrasound imaging. Unilateral left hemispheric lesions were much more common than right‐sided lesions (13 vs. 1, respectively).ConclusionsAn antenatal sonographic diagnosis of fetal stroke with IVH Grade III–IV or with brain parenchymal involvement appears to be associated with poor neurological outcome. MRI may contribute to the accuracy of diagnosis, particularly in Grade II and III lesions. Left‐sided unilateral lesions are more common than right‐sided ones. Copyright © 2005 ISUOG. Published by John Wiley & Sons, Ltd.
Cavernous lymphangioma of the face and neck: prenatal diagnosis by three‐dimensional ultrasound
Authors: Paladini D. , Vassallo M. , Sglavo G. , Lapadula C. , Longo M. , Nappi C. 
Published: August 2005

AbstractCavernous lymphangiomas are characterized by penetration through the subcutaneous areas between the muscular septa and represent rare variants of the more common superficial lymphangioma. Although frequently described in the fetus when involving the posterior aspect of the neck (i.e. cystic hygroma), involvement of the craniofacial region is rare. We describe the prenatal findings in a case of cavernous lymphangioma of the fetal face and neck, which extended caudally to envelop the larynx and the trachea. The anomaly was assessed by two‐ and three‐dimensional (3D) ultrasound. The latter approach was used thoroughly both during counseling with the couple and during consultation with the pediatric surgeon. This case report confirms the usefulness of the 3D approach in the management of rare fetal anomalies. In particular, the possibility of navigating the volume facilitated consultation with the pediatric surgeon and counseling of the parents. Copyright © 2005 ISUOG. Published by John Wiley & Sons, Ltd.
When Is Curative Gastrectomy Justified for Gastric Cancer with Positive Peritoneal Lavage Cytology but Negative Macroscopic Peritoneal Implant?
Authors: Miyashiro Isao , Takachi Ko , Doki Yuichiro , Ishikawa Osamu , Ohigashi Hiroaki , Murata Kohei , Sasaki Yo , Imaoka Shingi , Nakaizumi Akihiko , Takenaka Akemi , Furukawa Hiroshi , Hiratsuka Masahiro 
Published: August 2005

AbstractFor gastric cancer patients who have no peritoneal seeding at a macroscopic level but positive results in the peritoneal lavage cytology (PLC), the prognostic benefit expected by surgical resection is still controversial. During the period 1975–1994 as series of 417 consecutive patients without distant organ metastases underwent surgical resection for gastric cancer that had invaded the subserosal or deeper layers of the stomach wall. Immediately after laparotomy, the pouch of Douglas was washed with 100 ml of physiologic saline solution, and the fluid was collected for cytologic examination (four slide glasses) using Giemsa and Papanicolaou staining methods. According to the macroscopic (P) and cytologic (Cyt) results, the 417 patients were classified into three groups: P+ (n = 97); P−/Cyt+ (n = 25); and P−/Cyt− (n = 295). Their 3‐year survival rates after surgical resection were 4%, 24%, and 48%, respectively (p = 0.0001: P−/Cyt+ vs. P−/Cyt−; p = 0.0018: P−/Cyt+ vs. P+. Among the 25 P−/Cyt+ patients, postoperative survival was not associated with the T stage, N stage, cellular atypism, or cluster formation but with the number of cancer cells per slide during PLC. The 3‐year survival rate was 35% for the subgroup with fewer than 10 cancer cells per slide (17 patients) and 0% for the other subgroup with 10 or more cancer cells per slide (8 patients) (p = 0.017). For P−/Cyt+ patients, who represent a subgroup of gastric cancer patients with an intermediate survival rate between the P−/Cyt− and P+ patients, the number of cancer cells observed during PLC offers a potent prognostic indicator for the gastrectomy.
Abdominal Angina in Patients with a Midgut Carcinoid, a Sign of Severe Pathology
Authors: de Vries Harry , Wijffels Rob T. M. , Willemse Pax H. B. , Verschueren René C. J. , Kema Ido P. , Karrenbeld Arend , Prins Ted R. , de Vries Elisabeth G. E. 
Published: August 2005

AbstractIn 36 consecutive patients with a foregut carcinoid with extensive local tumor growth and liver metastases with a carcinoid syndrome, six patients had complaints of postprandial abdominal pain and attacks of subileus based on segmental intestinal ischemia. A diagnosis of abdominal angina was supported by a positive response to nitroglycerin in two and ischemia of the ileum demonstrated by angiography in two other patients. Complaints were reduced in all patients after surgery. Histopathology of the resected small bowel specimens showed elastic vascular sclerosis in three patients and ischemic changes in three other patients, confirming the clinical diagnosis. Resection of ischemic bowel can provide relief in patients with segmental intestinal ischemia caused by carcinoid‐induced vascular sclerosis.
Neuroimaging and the functional neuroanatomy of psychotherapy
Authors: ROFFMAN JOSHUA L. , MARCI CARL D. , GLICK DEBRA M. , DOUGHERTY DARIN D. , RAUCH SCOTT L. 
Published: August 2005

Background. Studies measuring the effects of psychotherapy on brain function are under-represented relative to analogous studies of medications, possibly reflecting historical biases. However, psychological constructs relevant to several modalities of psychotherapy have demonstrable neurobiological correlates, as indicated by functional neuroimaging studies in healthy subjects. This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders.Method. Fourteen published, peer-reviewed functional neuroimaging investigations of psychotherapy were identified through a MEDLINE search and critically reviewed. Studies were compared for consistency of findings both within specific diagnostic categories, and between specific modalities of psychotherapy. Results were also compared to predicted neural models of psychotherapeutic interventions.Results. Behavioral therapy for anxiety disorders was consistently associated with attenuation of brain-imaging abnormalities in regions linked to the pathophysiology of anxiety, and with activation in regions related to positive reappraisal of anxiogenic stimuli. In studies of major depressive disorder, cognitive behavioral therapy and interpersonal therapy were associated with markedly similar changes in cortical–subcortical circuitry, but in unexpected directions. For any given psychiatric disorder, there was only partial overlap between the brain-imaging changes associated with pharmacotherapy and those associated with psychotherapy.Conclusions. Despite methodological limitations, initial neuroimaging studies have revealed convergent and mechanistically sensible effects of psychotherapy on brain function across a range of psychiatric disorders. Further research in this area may take advantage of emerging neuroimaging techniques to explore a broader range of psychotherapies, with the ultimate goal of improving clinical decision-making and treatment.
Immigrants from the former Soviet Union, 5 years post-immigration to Israel: adaptation and risk factors for psychological distress
Authors: LERNER Y. , KERTES J. , ZILBER N. 
Published: August 2005

Background. Studies about the effect of time on the degree of psychological distress among immigrants have reported conflicting findings. We investigated this issue in Israel, which supports actively the absorption of immigrants, and also looked for risk and protective factors for psychological distress 5 years post-immigration.Method. A nationwide sample of 600 subjects who emigrated from the former Soviet Union to Israel in 1990 were interviewed in 1995, with the demoralization subscale of the Psychiatric Epidemiologic Research Interview (PERI-D) for psychological distress, and with a series of questions regarding sociodemographic characteristics, personal assets and their absorption experience. The results were compared with those obtained in a previous study for a sample of the same cohort of immigrants in their first year post-immigration. A multivariate analysis was carried out to examine the relation between the PERI score and the different independent variables.Results. Although, 5 years after immigration, a favorable change in objective parameters of absorption was found, no decrease in psychological distress was observed. The main risk factors remaining significantly associated with psychological distress in the final model were: adverse life events, lack of perceived social support, poor family functioning, external locus of control, poor physical health status, non-identification with host society and, to a lesser degree, poor material conditions.Conclusion. Psychological readjustment apparently takes longer than other processes of adaptation. Several years after immigration, social and psychological factors have a more important role for the well-being of immigrants than their material conditions.