bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplantation of mitochondria from human malignant tumor cells as a method of tumor growth formation in the lungs of laboratory animals
Authors: Kit O. I. , Frantsiyant E. M. , Shikhlyarova A. I. , Neskubina I. V. 
Published: December 2023

Purpose of the study. Obtaining lung cancer tumors in Balb/c Nude mice by transplantation of mitochondria isolated from human malignant tumors.Materials and methods. Human lung cancer mitochondria were isolated using differential centrifugation on a high-speed refrigerated centrifuge. Mitochondrial samples were diluted with 0.9 % NaCl solution to a protein concentration of 3 mg per animal. Freshly isolated lung cancer mitochondria were once transplanted into the tail vein of male Balb/c Nude mice (n = 6) at the rate of 3 mg of protein per 1 animal in 0.4 ml of saline. Male mice of Balb/c Nude line (n = 4), which were injected with 0.4 ml of physiological solution into the tail vein once a day, served as a control group. All animals were killed by guillotine decapitation 4 months after intravenous transplantation of mitochondria isolated from lung cancer.Results. After the introduction of mitochondria into the tail vein of mice, no changes were found in the animals’ behavior, coloration of coverings. No respiratory problems, and no allergic reactions to the introduction of foreign protein were detected. Respiratory problems in mice with mitochondrial transplantation occurred between days 113 and 123, when a drop in body weight ≥ 25 % was observed. A uniform formation of tumor nodes together with an active filling of the lung space with blood was clearly visible on lung preparations of a Balb/c Nude male mouse after intravenous transplantation of mitochondria from the lung of a patient with non-keratinizing squamous cell carcinoma. Similar characteristics of tumor growth in the lung parenchyma of the patient and Balb/c Nude mice as direct recipients of tumor mitochondria involved solid structures consisting of fields, cells and strands of tightly fitting atypical polymorphic cells of the squamous epithelium with poorly developed cytoplasm. In addition, signs of adenocarcinoma included glandular and papillary-like structures and cell complexes with large nucleoli. Squamous epithelial cells were characterized by severe atypia and polymorphism. The shape of the nuclei was irregular in most cells, with large sizes, the color was heterogeneous, and the nucleoli were enlarged. Multinucleated cells, as well as pathological mitoses with clearly marked division figures, which testified to their proliferative activity, were encountered with a rather high frequency.Conclusions. Application of intravenous transplantation of mitochondria isolated from malignant human lung tumor in male mice of Balb/c Nude line causes growth and development of malignant foci in male Balb/c Nude mice. This is previously unknown fact in experimental oncology, allowing the study of new properties of mitochondria of human cancer cells.
Correct Off-Site Determination of Seismic Sensor Orientation from Combined Analyses of Earthquake and Microseism Records
Authors: Park Seongjun , Hong Tae-Kyung 
Published: December 2023

ABSTRACT
Correct sensor orientation is vital for seismological analysis. However, seismic sensors including both borehole and surface seismometers are often installed in incorrect orientations. Individual methods proposed for sensor-orientation determination suffer from their own limitations and uncertainty, leaving the estimates in question before on-site verification. We introduce a method to combine a set of seismic phase analyses, yielding accurate sensor-orientation estimates. The method determines the sensor orientations by weighted-averaging independent estimates from three individual sensor-orientation analyses that are based on earthquake-origin P waves, earthquake-origin Rayleigh waves, and microseism-origin Rayleigh waves. The earthquake-origin seismic phase analyses may suffer from seismic anisotropy along ray paths even with accurate source-location information. On the other hand, the microseism-origin Rayleigh-wave analysis is hardly affected by seismic anisotropy along ray paths, being applicable to any seismic station with a couple of hour-long records. The three analyses complement each other, which enables us to determine representative sensor orientations correctly. We apply the proposed method to densely deployed 377 seismometers in South Korea, examining the sensor orientations. The representative sensor orientations are determined stably with standard errors less than 1°, supporting the accuracy of results. Borehole seismometers are poorly oriented relative to surface seismometers. The proposed method is useful for instant examination of sensor orientations of seismometers in remote regions and borehole seismometers in which physical accessibility is highly limited.
Дослідження операцій прогнозуючого контролю засобів зв’язку, навігації та спостереження
Authors: Зуєв О.В. , Соломенцев О.В. , Заліський М.Ю. , Осіпчук А.О. 
Published: December 2023

Засоби зв’язку, навігації та спостереження відіграють значну роль у процесі забезпеченні безпеки польотів цивільної авіації. Для підтримки надійності та ефективності використання цих засобів за призначенням застосовують системи експлуатації. Система експлуатації містить у своєму складі власне засоби зв’язку, навігації та спостереження, виконавців, документації, ресурсне забезпечення. Основними функціями системи експлуатації є: організація, координація, контроль технічної експлуатації об’єктів і засобів зв’язку, навігації та спостереження; проведення організаційно-технічних заходів щодо модернізації, підтримки експлуатаційної готовності й продовженню терміну служби цих засобів; планування, організація, координація й контроль робіт із сертифікації служб і об’єктів авіаційних засобів; планування, координація й контроль за проведенням льотних перевірок засобів; удосконалення й впровадження нових методів організації роботи, у тому числі на основі використання сучасних інформаційних технологій. Важливим процесом експлуатації є прогнозування технічного стану. У результаті прогнозування технічного стану засобів зв’язку, навігації та спостереження здійснюється оцінка значення сукупності визначальних параметрів. Практичне застосування алгоритмів прогнозуючого контролю передбачає зменшення похибок прийняття рішень про стан об‘єкта за наявністю апріорної невизначеності. Кількісною мірою об’єктивності прийнятих у результаті прогнозування рішень є достовірність прогнозуючого контролю. Достовірність загалом характеризує ступінь довіри до прийнятих у результаті прогнозування рішень. Від достовірності контролю залежить не тільки об’єктивність власне прогнозування, але й ефективність функціонування систем експлуатації засобів зв’язку, навігації та спостереження. Ця стаття присвячена дослідженню питань щодо особливостей застосування прогнозуючого контролю та оцінки достовірності прийняття рішень у результаті прогнозування. При цьому наведені математичні співвідношення, що характеризують процес класифікації технічного стану під час прогнозування та подальшої оцінки достовірності прийняття рішень. Результати дослідження можуть бути використані під час розробки та модернізації систем експлуатації засобів зв’язку, навігації та спостереження.
Opinions and Competencies of the Elderly and Disabled towards the Use of Mobile Devices and Applications
Authors: Bicen Huseyin , Bal Erkan , Serttas Zohre , Gur Pelin , Ese Vedia 
Published: December 2023

Many mobile applications have been developed for the elderly and disabled in recent years. The elderly and disabled can check their health information and access health services easier through mHealth (Mobile Health) applications. The aim of this study is to determine the competencies and opinions of the elderly and disabled towards these mobile devices and the NEU-LIFE ASSIST ANDROID application developed by researchers. In this context, the frequency with which the elderly and disabled use these devices and the effectivity of these devices has been researched. Therefore, the competencies of the elderly and disabled using mHealth applications can be determined and this data can be used in further studies. When the study findings regarding whether the elderly and disabled perceive themselves to be competent in using mobile devices are examined, it is observed that they can call, message and access information through the internet faster. When their opinions are considered, they stated that mobile devices and the NEU-LIFE ASSIST ANDROID application made their lives easier and improved their ability to communicate. Individuals who stated they could easily meet their needs at home using their mobile devices thought it would be more beneficial for mobile applications that enable this to be developed. Future studies should consider the development of more mobile applications that can be used in the field of health and investigate the effectivity of such applications.
Application of the Acral Coactivation Therapy Method in the Treatment of a Student Diagnosed with Idiopathic Adolescent Scoliosis
Authors: Vagner Jan , Bendíková Elena 
Published: December 2023

Background and Aim of Study: The aetiology of idiopathic scoliosis is still an unsolved problem. It is a three-dimensional spinal deformity that comprehensively impacts the musculoskeletal and cardiorespiratory systems. The aim of this pilot study was to find out how adolescent idiopathic scoliosis (AIS) can be treated by means of the Acral Coactivation Therapy (ACT) method. Material and Methods: The study was conducted on a 16-year-old student who had a body weight of 56 kg and a body height of 166 cm and was in his second year of high school. The student was diagnosed with AIS. We acquired data by means of standard medical-therapeutic methods and procedures applied in patients with AIS. Radiographic parametres, such as the Cobb angle as well as the Anterior and Posterior Trunk Symmetry Indexes (ATSI/POTSI), including the SCODIAC programme, were used to monitor the student’s progress. Results: In 2022, the student underwent a five-month exercise programme based on the ACT method, which was evaluated using clinical case study methods. The results showed a positive effect of the ACT method on the student’s spine curvature and body posture. There was an improvement of 21° in the thoracic curve and 20° in the curvature of his lumbar spine. In addition, the ATSI/POTSI improved from 36 to 7 (with a difference (r) of 29). Conclusions: The acquired qualitative data show a positive effect of the ACT method when it comes to correction of the curvature in a student diagnosed with adolescent idiopathic scoliosis. The stated finding also points to the importance of regular physical activity in the student's movement regime.
Küçük hücre dışı akciğer kanserlerinde immünhistokimyasal C-ERBB2 pozitivitesinin klinikopatolojik ve prognostik önemi
Authors: Toksöz Yıldırım Ayşe Nur , Vardar Aker Fügen , Erkan Murat 
Published: December 2023

Amaç: Meme ve mide karsinomlarında tedavi ve prognozda önemli rol oynayan C-ERBB2’nin küçük hücreli dışı akciğer karsinomlarında (KHDAK) önemi bilinmemektedir. Bu nedenle C-ERBB2’nin KHDAK’lardaki rolünü ve önemini ortaya koymak, ileride hedefe yönelik tedavide olası kullanım durumunda Türkiye’deki hastalardaki durumunu saptamaya yönelik pilot bir çalışma amaçlanmıştır.
Gereç ve Yöntemler: Bu çalışmaya, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Patoloji Bölümü’nde 2005-2014 tarihleri arasında KHDAK tanısı almış 258 olgu alındı. Vakalara ait hematoksilen eozin (H&E) boyalı lamlar değerlendirildi ve immünhistokimyasal C-ERBB2 boyama uygulandı. Boyanma şiddetine, komplet ve/veya inkomplet boyanmasına göre 1, 2, ve 3 olarak skorlandırıldı. C-ERBB2 skorları, klinikopatolojik ve prognostik özellikler ile karşılaştırıldı.
Bulgular: Vakaların %6.2’sinde C-ERBB2 pozitif olarak saptanmıştır. Pozitivite adenokarsinomlarda nispeten daha yüksektir. C-ERBB2 pozitivitesi ile klinikopatolojik (tümör tipi, subtipi, “grade”i, lenf nodu metastazı, lenfovasküler invazyon, plevral invazyon ve tümör çapı) ve prognostik özellikler (mortalite, genel sağkalım, progresyonsuz sağkalım, nüks) arasında istatistiksel olarak anlamlı bir ilişki saptanmamıştır.
Sonuçlar: Çalışmamızda C-ERB B2 overekspresyonu adenokarsinomlarda anlamlıya yakın dereceden daha fazla görülmüştür. Ancak KHDAK immünhistokimyasal C-ERBB2 pozitivitesinin, çalışmamızda ele aldığımız klinikopatolojik ve prognostik parametreler ile istatistiksel olarak anlamlı bir ilişkisi saptanmamıştır. Bu nedenle skor 2 ve 3 olan olgular insituhibridizasyon veya diğer genetik mutasyon incelemeleri ile tekrar test edilmeli; C-ERBB2 overekspresyon ya da mutasyonu olan hastaların klinikopatolojik ve prognostik parametreleri ile anti-HER2 tedavisine verecekleri cevabın belirlenmesi için ek çalışmalar yapılmalıdır.
Kahramanmaraş depremi sonrası psikososyal destek biriminden danışmanlık alan sağlık çalışanlarının travma sonrası stres bozukluğu verilerinin retrospektif değerlendirilmesi
Authors: UYAR Betül , SALMAN Barış Can , AYDAR Selma , BATIHAN Gülistan , SAVĞA Kübra , BALIKÇI Berna , BARAN Hüseyin , ÇANKAYA İNAN Ezgi , ARSLAN Ayça , GUNES Mehmet , KAYA Mehmet Cemal , BULUT Mahmut 
Published: December 2023

Amaç: Sağlık çalışanları felaket dönemlerinde diğer insanlara yardım ederken ihmal edilen bir meslek grubu gibi görünmektedir. Bu çalışmada Kahramanmaraş Depremi sonrasında sağlık çalışanlarının Travma Sonrası Stres Bozukluğu (TSSB) düzeyleri ile risk faktörlerinin belirlenmesi amaçlandı.
Gereç ve Yöntemler: Dicle Üniversitesi Hastanesi çalışan, 6 Şubat Kahramanmaraş depremi sonrası psikososyal destek ünitesine başvuran sağlık çalışanlarının sosyodemografik, klinik, Ulusal Stresli Olaylar Araştırması Kısa Ölçeği (NSESSS) ASB ve TSSB verileri geriye dönük olarak incelendi. Çalışmamıza depremi sonrası ilk 30 gün ve ikinci 30 günde iki kez değerlendirmeye alınan 102 kişinin verileri dahil edildi.
Bulgular: Katılımcıların yaş ortalaması 32,70±8,26 yıldı. %52'si kadın, %49'u evliydi ve %42,2'sinin çocuk sahibiydi. %38,2'si hekim, %35,3'ü hemşire ve %26,5'i diğer sağlık çalışanıydı. TSSB skorları çocuğu olanlarda olamaynalara göre, heşmşirelerde doktorlara göre, psikiyatrik özgeçmişi olanlarda olmayanlara göre anlamlı düzeyde yüksekti. Cinsiyet, medeni durum, psikiyatrik soygeçmişin ise ölçek skorlarına anlamlı etkisi yoktu. Basit doğrusal regresyon analizine göre ASB puanları TSSB puanlarını %40,6 yordamaktaydı.
Sonuçlar: Yüksek NSESSS-ASB skorları, çocuk sahibi olmak, hemşire olmak, psikiyatrik özgeçmişi olmak sağlık çalışanlarında TSSB geliştirmek için risk faktörleri olarak bulundu. Daha geniş örneklemli, daha uzun takip süreli çalışmalarla sağlık çalışanlarında TSSB için risk grupları tespit edilmeli ve koruyucu önlemler alınmalıdır.
RELATIONSHIPS OF HUMAN, RELIGION AND NATURE IN YUSUF QARDAWI'S PERSPECTIVE
Authors: Muhammad Izul Ridho  , Safrudin Edi Wibowo  , Pujiono  
Published: December 2023

ABSTRAK
Kajian tentang alam dan lingkungan dari sudut pandang agama khususnya kajian tafsir penting dilakukan guna menjawab dan melihat sejauh mana peran dan solusi yang ditawarkan agama di dalam pelestarian lingkungan. Maka penelitian ini akan mengungkap dua hal utama yaitu; penafsiran Yusuf Qardawi atas ayat-ayat larangan merusak lingkungan dan implikasinya pada masa depan pelestarian alam. Penelitian ini menggunakan pendekatan penafsiran ma’na cum maghza, metode peneltian yang digunakan ialah kualitatif library resarch, dengan jenis penelitian diskriptif analitis. Penelitian ini berhasil mengungkap bahwa: pertama, Yusuf Qardawi menafsirkan ayat-ayat larangan merusak lingkukngan (ifsad) dengan menetapkan pada keumuman ma’na dari kata ifsad dan turunannya sebagai maghza al-mutaharrik al-mu’ashir dari ayat-ayat tersebut, sehingga yang dimaksud dengan ifsad mencakup pada kerusakan alam yang tampak maupun tidak tampak oleh indra (ifsad al-ma’nawi dan ifsad al-madi). Kedua, pada aktualisasi maghza ayat-ayat ifsad nampak implikasi dari penafsiran Yusuf Qardawi secara ekologis yaitu berupa adanya solusi tahapan-tahapan pelestarian alam sebagai berikut; tahap pencegahan, tahap perbaikan dan tahap perawatan.

ABSTRACT
Studies on nature and the environment from a religious perspective, especially interpretation studies, are important to be carried out to answer questions and see the extent of the role and solutions offered by religion in environmental preservation. Therefore, this research will reveal two main things: Yusuf Qardawi's interpretation of the verses prohibiting harming the environment and their implications for the future of nature conservation. This study used the interpretation approach of ma'na cum maghza. The research method used was qualitative library research, with analytical descriptive as the type of research. This study succeeded in revealing that: first, Yusuf Qardawi interpreted the verses prohibiting harming the environment (ifsad) by specifying the generality of the meaning of the word ifsad and its derivatives as maghza al-mutaharrik al-mu'ashir from these verses; thus, what is meant by ifsad includes damage to nature that is visible or invisible to the senses (ifsad al-ma'nawi and ifsad al-madi). Second, in the actualization of the maghza verses of ifsad, the implications of Yusuf Qardawi's ecological interpretation appear, namely in the form of a solution to the stages of nature conservation as follows: prevention stage, repair stage and maintenance stage.
Ultimum Remedium Principle in Indonesian Tax Regime – Impact and Challenges Post-Omnibus Law
Authors: Ariaputra Denny 
Published: December 2023

The tax laws are built to ensure that every citizen obeys their obligation on tax. Or, in other perspectives, to guarantee the state does not lose the right to collect tax from the people. Tax laws are part of the state administrative laws. As a consequence, the penalty that is equipped with tax law is also known as administrative sanctions. However, since tax is an essential state element, tax law provided a criminal penalty to give a more complex impact and the value of a deterrent effect (known as administrative penal law). Every tax jurisdiction has characteristics and depends on the state’s main objectives and preferences. Indonesia’s tax regime prioritizes tax collection and the recovery of state losses rather than sending the taxpayer to jail. This concept is known as ultimum remedium or the last remedy principal. After the Corvid-19 pandemic, Indonesia tries to raise the economy through many breakthroughs in tax law, including the enactment of Law of the Republic of Indonesia N0.11 of 2020 on job creation (also known as omnibus law) and Law of the Republic of Indonesia No.7 of 2021 on Harmonization on Tax Regulation. Both regulations have the same spirit to boost Indonesia’s economy through fiscal policy, including relaxation of the tax penalty. With its impact and challenges, this policy is expected to create a broader opportunity for Indoesia tax authorities to collect more tax
The stress-strain state of an incompressible prestressed half-space with a protective coating under the action of a moving load
Authors: Gluchov Uriy 
Published: December 2023

This work is devoted to the study of the influence of the protective coating, initial stresses, mechanical characteristics of materials, movement parameters of the surface load on the stress-deformed state of the elastic base. The relevance of the research results is related to the possibility of their use in the creation of qualitatively new materials, structures and building structures. A prestressed incompressible half-space with inhomogeneity in the form of a thin surface layer is considered. The concentrated force moves along the free surface of the protective layer at a constant speed at a certain angle to the surface of the half-space. The solution of the problem was obtained using the method of integral Fourier transformations. Analytical results are given in a general form for materials with an arbitrary elastic potential, for cases of unequal and equal roots of characteristic equations, for various conditions of combination of elements of a layered medium and for any speed of movement of the load. The material with the Bartenev-Khazanovich potential was considered for numerical analysis. The calculations were carried out within the framework of the theory of finite initial deformations. The impact of the moving load, initial stresses and mechanical parameters of the elements of the layered base on the main characteristics of its stress-strain state was studied.
Teachers in Danish upper secondary education’s conceptualisation of career learning: A Koselleck inspired study
Authors: Felby Laura Cordes , Skovhus Randi Boelskifte 
Published: December 2023

This study explores the translation and negotiation of career learning as a newly introduced concept in the context of academic Danish upper secondary education, shedding light on teachers’ understanding of the concept and its connection to their teaching practice. In the study, we draw on observations and interviews with ten teachers. Using Koselleck’s asymmetric counter concepts, the analysis shows that the negotiation of meaning is complex, and full of internal and external paradoxes. Last, the study argues that in practice, there is goodwill and a desire to occupy the concept by the teachers when it can be linked to meaningful teaching practice.
Surgical Corner of the Mouth Lift – Case Study
Authors: Komisarek Oskar , Kwiatkowski Jacek , Matthews-Brzozowski Artur 
Published: December 2023

A smile is an expression of joy and sympathy, serving as a vital element of social communication. The process of aging has a notable impact on both skin elasticity and muscle tone, which consequently results in alterations in the appearance of the corners of the mouth and the overall smile. Notably, the emergence of 'marionette lines,' vertical wrinkles extending from the mouth's corners to the base of the chin, signifies a visible manifestation of the aging process. These changes exert influence on both aesthetic aspects and personal hygiene, potentially leading to the development of inflammatory conditions.This article presents a case study focusing on a female patient who underwent surgical correction of the mouth's corners due to recurrent angular cheilitis. The patient presented with ptotic mouth corners, excessive salivation, and erythema at the angles of the mouth, often accompanied by painful discomfort during exacerbations of the inflammatory condition. The treatment method applied in this specific case involved the utilization of the triangular technique. Subsequent to the surgical procedure, the patient expressed satisfaction with the outcome, and her mouth corners remained free from inflammatory episodes for a duration of two years.
Defects in high‑pressure die casting and measures to prevent gas defects
Authors: Chechukha V. I. , Sadokha M. A. 
Published: December 2023

The formation of defects in the manufacturing of castings is influenced by numerous factors. These factors can affect the quality both individually and in combination. This article provides a characterization of the defects encountered in high‑pressure die casting and identifies the factors influencing their formation. Effective measures are examined to reduce casting defects, which are recommended for obtaining critical and highly demanding castings with stringent surface requirements after mechanical processing.The use of automated high‑pressure die casting complexes in production has a positive impact on the quality of castings, eliminating many of the potential causes of defects related to human factors.