bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domain-specific Cognitive Impairments, Mood and Quality of Life 6 Months After Stroke
Authors: Milosevich Elise , Kusec Andrea , Pendlebury Sarah T. , Demeyere Nele 
Published: January 2024

ABSTRACTPurposeTo identify which acute and 6-month domain-specific cognitive impairments impact mood functioning, participation, and stroke-related quality of life 6 months after stroke.Materials and MethodsA prospective cohort of 430 stroke survivors completed the Oxford Cognitive Screen (OCS) acutely and 6 months post-stroke. Participants completed the Stroke Impact Scale (SIS) and Hospital Depression and Anxiety Scale (HADS) at 6 months. Multivariable regression analyses assessed whether severity of, and domain-specific, cognitive impairment acutely and at 6 months was associated with composite 6-month SIS scores, each SIS subscale, and HADS scores.ResultsIncreased severity of cognitive impairment acutely and at 6 months was associated with lower 6-month SIS composite scores independent of age, sex, education years, and stroke severity (bothp<0.001). Domain-specific impairments in memory (p<0.001) and attention (p=0.002) acutely, and language (p<0.001), memory (p=0.001) and number processing (p=0.006) at 6 months showed the strongest associations with worse SIS composite scores. Severity of acute and 6-month cognitive impairment was associated with poorer functioning in each SIS subscale, as well as greater levels of depression (acutep=0.021, 6-monthsp<0.001), but not anxiety (p=0.174,p=0.129).ConclusionsBoth acute and 6-month domain-specific cognitive impairments, particularly in memory, were found to negatively impact overall functional and mood outcomes 6 months post-stroke.
Direct and Indirect Genetic Effects on Early Neurodevelopmental Traits
Authors: Hegemann Laura , Eilertsen Espen , Pettersen Johanne Hagen , Corfield Elizabeth C. , Cheesman Rosa , Frach Leonard , Bjørndal Ludvig Daae , Ask Helga , St Pourcain Beate , Havdahl Alexandra , Hannigan Laurie J. 
Published: January 2024

AbstractBackgroundNeurodevelopmental conditions are highly heritable and frequently co-occur within individuals. Recent studies have shown that SNP heritability estimates can be confounded by genetic effects mediated via the environment (indirect genetic effects). However, the relative importance of directversusindirect genetic effects on early manifestations of neurodevelopmental conditions is unknown.MethodsThe sample included up to 24,692 parent-offspring trios from the Norwegian MoBa cohort. We use Trio-GCTA to estimate latent direct and indirect genetic effects on mother-reported neurodevelopmental traits at age three years (restricted and repetitive behaviors and interests, attention, hyperactivity, language, social, and motor development). Further, we investigate to what extent direct and indirect effects are attributable to common genetic variants associated with autism, ADHD, developmental dyslexia, educational attainment, and cognitive ability using polygenic scores (PGS) in regression modeling.ResultsWe find evidence for contributions of direct and indirect latent common genetic effects contributing to attention (direct: explaining 4.8% of variance, indirect: 6.7%) hyperactivity (direct: 1.3%, indirect: 9.6%), and restricted and repetitive behaviors (direct effects: 0.8%, indirect effects: 7.3%). Variation in social and communication, language, and motor development was best explained by direct effects (5.1-5.7%). Direct genetic effects on attention were captured by PGS for ADHD, autism, educational attainment, and cognitive ability, whereas direct genetic effects on language development were captured by cognitive ability and autism PGS. Indirect genetic effects were primarily captured by educational attainment and/or cognitive ability PGS across all outcomes.ConclusionsResults were consistent with differential contributions to neurodevelopmental traits in early childhood by direct and indirect genetic effects. Indirect effects were particularly important for hyperactivity and restricted and repetitive behaviors and interests, and may be linked to genetic variation associated with cognition and educational attainment. Within-family approaches are important for disentangling genetic processes that influence early neurodevelopmental traits, even when identifiable associations are small.
EEG signatures at different propofol vs sevoflurane concentrations
Authors: Sun C. , Rigouzzo A. , Constant I. , Holcman D. 
Published: January 2024

AbstractThe depth of anesthesia is contingent upon the concentration of administered hypnotics, but establishing an exact relationship proves challenging, given its variability among individual patients. To elucidate the connection between the depth of anesthesia and hypnotic concentration, we leverage transient EEG patterns—specifically, iso-electric suppressions and power distributions within theαandδfrequency bands—at constant concentrations. Our investigation focuses on two hypnotic: propofol and sevoflurane. In a cohort encompassing children and young adults undergoing general anesthesia, we employ segmentation algorithms to extract a diverse range of spectral representations in EEG profiles. However, as we systematically alter hypnotic concentrations, a consistent trend emerges: heightened hypnotic concentration predominantly aligns with increasedδ-band power and reducedα-band power. Notably, the occurrence of iso-electric suppressions is primarily associated with elevated propofol concentrations and infrequently observed with high levels of sevoflurane. Furthermore, we observe a decrease in the maximal power frequency of theα-band as hypnotic concentrations increase. In summary, this study offers a systematic quantification of EEG patterns corresponding to distinct concentrations of propofol and sevoflurane. These observed patterns contribute to a nuanced EEG representation of brain activity, laying the groundwork for personalized anesthesia strategies.
Reporting Quality in Health Economic Evaluation Studies of Immune Checkpoint Inhibitors: A Systematic Review
Authors: Yoshioka Takashi , Azuma Shintaro , Funada Satoshi , Itaya Takahiro , Goto Rei 
Published: January 2024

AbstractObjectivesThis study assessed the reporting quality of health economic evaluation (HEE) studies of immune checkpoint inhibitors (ICIs).MethodsWe conducted a systematic literature search of four databases (PubMed, EMBASE, Cochrane CENTRAL, and the International HTA Database) for studies published between January 1, 2014 and December 31, 2022. Three pairs of reviewers independently screened and reviewed the full text and extracted the data. We included all ICIs approved up to December 31, 2022, in the United States (US), European Union, China, and Japan. Reporting quality was assessed using the Consolidated Health Economic Evaluation Reporting Standards published in 2013 (CHEERS 2013). Subgroup analyses were also performed based on the risk of sponsorship bias or citation of CHEERS 2013.ResultsA total of 5,368 records were identified, 252 of which were included after full-text review. The study design, setting, and ICIs most frequently observed were cost-effectiveness and cost-utility analyses (63.5%), the US (46.0%), and pembrolizumab (38.1%), respectively. Of the 24 items of CHEERS 2013, fully reported items were limited, particularly in the Methods section. Setting and location were not reported in 94.4% of the records. Similar trends were observed in subgroup analysis.ConclusionHEE studies on ICIs between 2014 and 2022 had limited reporting across the 24 items of CHEERS 2013, regardless of sponsorship bias risk or citations. The items on setting and location in the Methods section were particularly underreported, emphasizing the need for transparent reporting in HEE studies of ICIs.HighlightsThe reporting quality of health economic evaluation (HEE) studies was evaluated using the Consolidated Health Economic Evaluation Reporting Standards published in 2013 (CHEERS 2013). However, the reporting quality of HEEs of immune checkpoint inhibitors (ICIs), which is an emerging health policy issue for the economic burden of cancer, remains unknown.Despite the passage of a decade since the publication of CHEERS 2013, HEE studies on ICIs have generally not fully adhered to the CHEERS 2013 guidelines in the Methods section. This is particularly evident in the setting and location items, even after stratification by the presence or absence of risk of sponsorship bias or whether CHEERS 2013 statement was cited.This study highlights the insufficient reporting of CHEERS items among current HEE studies of ICIs, especially in the Methods section, to researchers who conduct HEE studies of ICIs, and informs policymakers and stakeholders who refer to HEE studies of ICIs about underreporting.
The effect of dietary fish oil replacement by microalgae on the gilthead sea bream midgut bacterial microbiota
Authors: Katsoulis-Dimitriou Stefanos , Nikouli Eleni , Gkalogianni Elli Zafeiria , Karapanagiotidis Ioannis T. , Kormas Konstantinos A. 
Published: January 2024

ABSTRACTIt is well known that the gut microbiome and its interaction with the host influence several important factors for fish health such as nutrition and metabolism. Diet is one of the main factors influencing the composition of the gut microbiome in reared fish. Microalgae, due to their high fatty acid content, appear to be a promising alternative for replacing fish oil in aquafeed. Thus, the aim of this work was to evaluate the effects of dietary microalgae blends as fish oil replacers on the midgut bacterial microbiota of the gilthead sea bream (Sparus aurata). The control diet (FO) contained only fish oil as source of lipids, EPA and DHA fatty acids, while three experimental diets were used where fish oil was replaced at 67% by one of the following microalgae biomass blends:Microchloropsis gaditanaandIsochrysissp. (Tisochrysis lutea) (MI),Phaeodactylum tricornutumandIsochrysissp. (PI) andSchizochytriumsp. andP. tricornutum(SP). The midgut bacterial community composition of the experimental diets was altered compared to the control diet. There were 11 operational taxonomic units (OTUs) which were highly abundant in FO compared to the three experimental diets (FO, MI, SP) and two OTUs that were found in high abundance in both FO and the experimental diets in all comparisons (FO-MI, FO-PI, FO-SP). Most of the highly abundant OTUs in the experimental diets were unique to each experimental diet, with two OTUs being found in common between FO-MI and FO-PI. Additional evidence from the presumptive bacterial functional metabolic pathways suggested that the microalgae-based diets resulted in one over-expressed and one under-expressed pathway. The overexpressed pathway was related to the metabolism of fucose, a major constituent of the polysaccharide content of several microalgal species. Peptidoglycan biosynthesis was the under-expressed metabolic pathway. This suggests that a new gut microbiota profile was selected due to the microalgae inclusion in the provided diet. This study showed that, with the absence of mortality in fish, the gilthead sea bream gut microbiome can smoothly adapt its function according to the metabolic capacity of the dietary microalgae combinations that were used. The MI feed seems to promote several beneficial bacteria with potential probiotic abilities in the fish gut, belonging to thePseudoalteromonas, Pseudomonas, BacillusandRhodopseudomonasgenera.
Congenital diaphragmatic eventration: Should we maintain surgical treatment? A retrospective multicentric cohort study
Authors: Heng Lymeymey , Alzahrani Khalid , Khen-Dunlop Naziha , Panait Nicoleta , Hervieux Erik , Grynberg Lucie , Abbo Olivier , Hameury Frédéric , Lavrand Frédéric , Maillet Olivier , Haffreingue Aurore , Lehn Anne , De Napoli Cocci Stephan , Habonimana Edouard , Michel Jean-Luc , Montalva Louise , Ballouhey Quentin , Kamdem Arnaud Fotso , Lecompte Jean-François , Liné Antoine , Poupalou Anna , Maignan Pierre , Deslandes Loren , Podevin Guillaume , Schmitt Françoise 
Published: January 2024

AbstractBackgroundCongenital diaphragmatic eventration (CDE) is an infrequent congenital pathology without consensus of treatment. This study assessed current care practices for this pathology in children in France.MethodsRetrospective study on cohort data conducted in 22 paediatric surgery departments, including patients less than 16 years of age followed for CDE since 2010. Patients with surgical or conservative treatment were compared.Results139 patients were included, with a median age of 8 [1 – 16] months. CDE occurred in boys in 68.3% and was right-sided in 66.7% of the cases. It was symptomatic in 65% of the cases, with a respiratory component for 97% of these patients. The primary indication for treatment, essentially depending on the clinical respiratory impairment and the level of the diaphragm, was surgery for diaphragmatic plication in 87 cases (62%) or clinical follow-up for the 52 others, 25 of whom were operated on secondarily. There were 32 early per- or postoperative complications (29%), and 8 recurrences of eventration (7%). With a median follow-up of 28 months, the median level of diaphragmatic dome fell from the 6th to the 9th back rib, and the rate of respiratory symptoms from 64% to 14%, in both surveyed and surgically treated patients.ConclusionsCDE is mainly diagnosed in newborn or infant boys and right-sided. Diaphragmatic plication may be the best treatment in symptomatic patients with a dome level upper the 6thposterior rib, but exposes them to a 29% complication rate and 7% of recurrence.ClinicalTrialsNCT04862494, April 28, 2021.What’s new?Boys are indeed more affected than girls (68.3%), but left-side eventration only happens in 33% of cases.As compared to conservative management, surgery may be positively associated with diaphragmatic level improvement, but not with long term resolution of symptoms.
Machine Learning Models Predict the Emergence of Depression in Argentinean College Students during Periods of COVID-19 Quarantine
Authors: López Steinmetz Lorena Cecilia , Sison Margarita , Zhumagambetov Rustam , Godoy Juan Carlos , Haufe Stefan 
Published: January 2024

ABSTRACTINTRODUCTIONThe COVID-19 pandemic has exacerbated mental health challenges, particularly depression among college students. Detecting at-risk students early is crucial but remains challenging, particularly in developing countries. Utilizing data-driven predictive models presents a viable solution to address this pressing need.AIMS: 1)To develop and compare machine learning (ML) models for predicting depression in Argentinean students during the pandemic.2)To assess the performance of classification and regression models using appropriate metrics.3)To identify key features driving depression prediction.METHODSA longitudinal dataset (N = 1492 college students) captured T1 and T2 measurements during the Argentinean COVID-19 quarantine. ML models, including linear logistic regression classifiers/ridge regression (LogReg/RR), random forest classifiers/regressors, and support vector machines/regressors (SVM/SVR), are employed. Assessed features encompass depression and anxiety scores (at T1), mental disorder/suicidal behavior history, quarantine sub-period information, sex, and age. For classification, models’ performance on test data is evaluated using Area Under the Precision-Recall Curve (AUPRC), Area Under the Receiver Operating Characteristic curve, Balanced Accuracy, F1 score, and Brier loss. For regression, R-squared (R2), Mean Absolute Error, and Mean Squared Error are assessed. Univariate analyses are conducted to assess the predictive strength of each individual feature with respect to the target variable. The performance of multi- vs univariate models is compared using the mean AUPRC score for classifiers and R2 score for regressors.RESULTSThe highest performance is achieved by SVM and LogReg (e.g., AUPRC: 0.76, 95% CI: 0.69, 0.81) and SVR and RR models (e.g., R2 for SVR and RR: 0.56, 95% CI: 0.45, 0.64 and 0.45, 0.63, respectively). Univariate models, particularly LogReg and SVM using depression (AUPRC: 0.72, 95% CI: 0.64, 0.79) or anxiety scores (AUPRC: 0.71, 95% CI: 0.64, 0.78) and RR using depression scores (R2: 0.48, 95% CI: 0.39, 0.57) exhibit performance levels close to those of the multivariate models, which include all features.DISCUSSIONThese findings highlight the relevance of pre-existing depression and anxiety conditions in predicting depression during quarantine, underscoring their comorbidity. ML models, particularly SVM/SVR and LogReg/RR, demonstrate potential in timely detection of at-risk students, enabling preventive measures for improved mental health outcomes.
October 2018 – December 2023 time-series analysis of pediatric RSV immunizations and RSV-associated hospitalizations
Authors: Cartwright Brianna M. Goodwin , Gratzl Samuel , Rodriguez Patricia J , Baker Charlotte , Stucky Nick 
Published: January 2024

AbstractThis study describes two population under age two 1) who received an RSV immunization and 2) experienced RSV-associated hospitalizations since 2018. Results show low uptake of the RSV immunization. RSV-associated hospitalizations exhibited earlier and higher peaks in the 2021/22 and 2022/23 seasons compared to previous years.
Precarious employment amidst global crises: career shocks, resources and migrants' employability
Authors: Kerti Kornélia Anna , Van Engen Marloes , Szabó Orsolya , Kroon Brigitte , Bleijenbergh Inge , Freese Charissa 
Published: January 2024

Purpose The authors conducted 22 in-depth longitudinal interviews with 11 Hungarian migrant workers in the Dutch logistics sector, before and during the COVID-19 crisis, using thematic analysis and visual life diagrams to interpret them.Design/methodology/approach This study aims to contribute to conservation of resources theory, by exploring how global crises influence the perceived employability of migrant workers in low-wage, precarious work.Findings The authors find that resources are key in how migrants experience the valence of global crises in their careers and perceive their employability. When unforeseen consequences of the COVID-19 crisis coincided with migrants' resource gain spirals, this instigated a positively valenced career shock, leading to positive perceptions of employability. Coincidence with loss spirals led to negative perceptions.Research limitations/implications The authors contribute to careers literature by showing that resources do not only help migrants cope with the impact of career shocks but also directly influence the valence of global crises in their perceived employability and careers.Originality/value Interestingly, when the COVID-19 crisis did not co-occur with migrants' resource gain and loss spirals, migrants experienced resource stress (psychological strain induced by the threat or actual loss of resources) and no significant change in their perceptions of employability.
Quality of work-life situation and effectiveness of labour laws: managerial perspectives
Authors: Shrestha Prakash , Parajuli Dilip , Adhikari Bibek Raj 
Published: January 2024

Purpose
This paper aims to examine the current quality of work-life (QWL) situation and the effectiveness of labor laws for promoting QWL in the context of Nepalese workplaces.

Design/methodology/approach
It uses a descriptive-interpretative-qualitative approach to analyze the responses. Information is gathered through discussions with 85 higher- and middle-level managers of large and medium-sized organizations.

Findings
The majority of Nepalese organizations accept safe and healthy working conditions, social relevance of work-life, social integration in the work organization, and work and total life space as the key aspects of QWL. They have become even more critical as a result of the COVID-19 pandemic. However, they face challenges in providing employees with opportunities for continued growth and security, immediate opportunity to use and develop human capacities, adequate and fair compensation and constitutionalism in the work organization. QWL-related provisions in Labour Act, 2017, play a vital role in promoting the QWL situation. The QWL programs offer many benefits to employees’ private and working lives. The lack of such programs would undoubtedly have negative consequences for Nepalese companies. Compliance with labor laws will promote a better QWL situation at Nepalese workplaces.

Research limitations/implications
Only managerial perspectives are considered for examining the current situation of QWL and the effectiveness of QWL-related provisions of the Labour Act, 2017. It excludes the views of union leaders.

Practical implications
This paper indicates that labor laws’ QWL-related provisions are effective. It also provides several policy measures for promoting a better QWL in Nepalese workplaces.

Originality/value
This study presents QWL-related legal provisions and the actual situation at the workplaces of Nepal. It also presents the key aspects of QWL in the context of Nepal.
Effects of interactions between technology spillovers and carbon transfers on carbon emission reduction decisions and coordination within supply chains
Authors: Jiang Xiaozhuang , Sun Licheng , Wang Yushi 
Published: January 2024

Purpose
This paper aims to refine the mechanisms affecting the two-way technology spillover and carbon transfer interactions between supply chain enterprises, and to guide their reduction of carbon emissions.

Design/methodology/approach
This study formulates a supplier-led Stackelberg game model to explore the effects of the interactions between two-way technology spillover effects and carbon transfers in decentralized and centralized decision-making scenarios. The optimized Shapley value is introduced to coordinate across the supply chain and determine the overall profits lost in the decentralized scenario.

Findings
Emission reductions by the low-carbon manufacturer are negatively correlated with the carbon transfers. Vertical technology spillovers promote carbon reduction, whereas horizontal technology spillovers inhibit it. The vertical technology spillovers amplify the negative effects of the carbon transfers, whereas the horizontal technology spillovers alleviate these negative effects. When the vertical technology spillover effect is strong or the horizontal technology spillover effect is weak in the centralized scenario, the carbon reduction is negatively correlated with the carbon transfers. Conversely, when the vertical technology spillover effect is weak or the horizontal technology spillover effect is strong, the enterprise’s carbon reduction is positively correlated with the carbon transfers. An optimized Shapley value can coordinate the supply chain.

Originality/value
This study examines the effects of carbon transfers on enterprises from a micro-perspective and distinguishes between vertical and horizontal technology spillovers to explore how carbon transfers and different types of technology spillovers affect enterprises’ decisions to reduce carbon emissions.