bluuebunny/crossref_metadata_2025_split huggingface dataset:
From wide to ultrawide-bandgap semiconductors for high power and high frequency electronic devices
Authors: Woo Kelly , Bian Zhengliang , Noshin Maliha , Perez Martinez Rafael , Malakoutian Mohamadali , Shankar Bhawani , Chowdhury Srabanti 
Published: January 2024

Abstract
Wide and ultrawide-bandgap (U/WBG) materials have garnered significant attention within the semiconductor device community due to their potential to enhance device performance through their substantial bandgap properties. These exceptional material characteristics can enable more robust and efficient devices, particularly in scenarios involving high power, high frequency, and extreme environmental conditions. Despite the promising outlook, the physics of UWBG materials remains inadequately understood, leading to a notable gap between theoretical predictions and experimental device behavior. To address this knowledge gap and pinpoint areas where further research can have the most significant impact, this review provides an overview of the progress and limitations in U/WBG materials. The review commences by discussing Gallium Nitride, a more mature WBG material that serves as a foundation for establishing fundamental concepts and addressing associated challenges. Subsequently, the focus shifts to the examination of various UWBG materials, including AlGaN/AlN, Diamond, and Ga2O3. For each of these materials, the review delves into their unique properties, growth methods, and current state-of-the-art devices, with a primary emphasis on their applications in power and radio-frequency electronics.
Mechanical properties and hydration behavior of dehydrated cement paste-slag based composite cementitious material
Authors: Zhang Ruofei , Tang Ning , Du Wenjie , Nie Nan 
Published: January 2024

Abstract
Mechanical properties are critical in engineering applications involving cementitious materials. While dehydrated cement paste-based materials are considered environmentally friendly, they suffer from poor mechanical properties, limiting their engineering applications. Therefore, enhancing the mechanical properties of these materials is crucial to overcoming their limitations in engineering and supporting the development of sustainable building engineering. Based on the pozzolanic reaction mechanism and alkali activation theory, a composite cementitious material was created by combining dehydrated cement paste with slag. Na2SiO3 and NaAlO2 were used as alkali activators. The study investigated the effects of the ratio of dehydrated cement paste to slag, alkali activator dosage, water-binder ratio, and calcination temperature on the material’s mechanical properties through an orthogonal test. The optimized ratio, determined through the orthogonal test and mathematical model, resulted in a compressive strength of 37.33 MPa (7d) and 46.89 MPa (28d), surpassing the compressive strength of the original Portland cement paste. Hydration products of the composite cementitious material primarily comprised C-(A)-S-H, C-A-H, and CaCO3, with no observed presence of AFt, AFm, and Ca(OH)2. Notably, the hydration products of the composite material exhibited clear distinctions from those of Portland cement.
Inductor based I-V curve measurement method for photovoltaic panels
Authors: Borekci S , Acar N C 
Published: January 2024

Abstract
The output power of a photovoltaic panel (PV) depends on temperature and irradiance. Aging, partial shading and electrical load can also affect the operating current and voltage of PV systems. I-V curve tracers are used to determine the performance of PV panels in any environmental condition and are widely used in both the design and operation of PV systems. In this study, a simple, effective, and rapid I-V curve tracer method is described for photovoltaic (PV) panels. The method is developed based on transient analyses of the current and voltage of an inductor load that is connected to a 175 W standalone PV panel via a semiconductor switch. The I-V and P-V characteristics curves of the PV panel are obtained in a few microseconds rapidly.
Amortized simulation-based frequentist inference for tractable and intractable likelihoods
Authors: Al Kadhim Ali , Prosper Harrison B , Prosper Olivia F 
Published: January 2024

Abstract
High-fidelity simulators that connect theoretical models with observations are indispensable tools in many sciences. If the likelihood is known, inference can proceed using standard techniques. However, when the likelihood is intractable or unknown, a simulator makes it possible to infer the parameters of a theoretical model directly from real and simulated observations when coupled with machine learning. We introduce an extension of the recently proposed likelihood-free frequentist inference (LF2I) approach that makes it possible to construct confidence sets with the p-value function and to use the same function to check the coverage explicitly at any given parameter point. Like LF2I, this extension yields provably valid confidence sets in parameter inference problems for which a high-fidelity simulator is available. The utility of our algorithm is illustrated by applying it to three pedagogically interesting examples: the first is from cosmology, the second from high-energy physics and astronomy, both with tractable likelihoods, while the third, with an intractable likelihood, is from epidemiology
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Code to reproduce all of our results is available on https://github.com/AliAlkadhim/ALFFI.
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BCFtools/liftover: an accurate and comprehensive tool to convert genetic variants across genome assemblies
Authors: Genovese Giulio , Rockweiler Nicole B , Gorman Bryan R , Bigdeli Tim B , Pato Michelle T , Pato Carlos N , Ichihara Kiku , McCarroll Steven A 
Published: January 2024

Abstract

Motivation
Many genetics studies report results tied to genomic coordinates of a legacy genome assembly. However, as assemblies are updated and improved, researchers are faced with either realigning raw sequence data using the updated coordinate system or converting legacy datasets to the updated coordinate system to be able to combine results with newer datasets. Currently available tools to perform the conversion of genetic variants have numerous shortcomings, including poor support for indels and multi-allelic variants, that lead to a higher rate of variants being dropped or incorrectly converted. As a result, many researchers continue to work with and publish using legacy genomic coordinates.

Results
Here we present BCFtools/liftover, a tool to convert genomic coordinates across genome assemblies for variants encoded in the variant call format with improved support for indels represented by different reference alleles across genome assemblies and full support for multi-allelic variants. It further supports variant annotation fields updates whenever the reference allele changes across genome assemblies. The tool has the lowest rate of variants being dropped with an order of magnitude less indels dropped or incorrectly converted and is an order of magnitude faster than other tools typically used for the same task. It is particularly suited for converting variant callsets from large cohorts to novel telomere-to-telomere assemblies as well as summary statistics from genome-wide association studies tied to legacy genome assemblies.

Availability and implementation
The tool is written in C and freely available under the MIT open source license as a BCFtools plugin available at http://github.com/freeseek/score.
Baricitinib statistically significantly reduced COVID-19-related mortality: a systematic review and meta-analysis of five phase III randomized, blinded and placebo-controlled clinical trials
Authors: Manoharan Sivananthan , Ying Ying Lee 
Published: January 2024

Abstract
Due to high heterogeneity and risk of bias (RoB) found in previously published meta-analysis (MA), a concrete conclusion on the efficacy of baricitinib in reducing mortality in coronavirus disease 2019 (COVID-19) patients was unable to form. Hence, this systematic review and MA were conducted to analyse whether RoB, heterogeneity, and optimal sample size from placebo-controlled randomized controlled trials (RCTs) are still the problems to derive a concrete conclusion.
Search engines PubMed/MEDLINE, ScienceDirect, and other sources like preprints and reference lists were searched with appropriate keywords. The RoB and MA were conducted using RevMan 5.4. The grading of the articles was conducted using the GRADEPro Guideline Development Tool.
Ten RCTs were included in the current systematic review. Only five low RoB articles are Phase III placebo-controlled RCTs with a high certainty level based on the GRADE grading system. For the MA, based on five low RoB articles, baricitinib statistically significantly reduced mortality where the risk ratio (RR) = 0.68 [95% confidence interval (95% CI) 0.56–0.82; P &lt; 0.0001; I2 = 0%; P = 0.85]. The absolute mortality effect (95% CI) based on the grading system was 35 fewer mortalities per 1000 COVID-19 patients, whereas in the baricitinib and control groups, the mortality was 7.4% and 10.9%, respectively.
With the presence of an optimal sample size of 3944 from five low RoB–placebo-controlled RCTs, which represent a minimum of 300 million population of people and with the presence of 0% heterogeneity from MA, the effectiveness of baricitinib in reducing the mortality in COVID-19 patients is concretely proven.
The construct validity, responsiveness, reliability and interpretability of the Recap of atopic eczema questionnaire (RECAP) in children
Authors: Ragamin Aviël , Zhang Junfen , Pasmans Suzanne G M A , Schappin Renske , Romeijn Geertruida L E , van Reusel Maroos A , Oosterhaven Jart A F , Schuttelaar Marie L A 
Published: January 2024

Abstract

Background
The Recap of atopic eczema questionnaire (RECAP) was developed to measure eczema control in patients with atopic dermatitis (AD). The measurement properties of RECAP have not yet been validated in caregivers of children with AD.

Objectives
To assess the construct validity, responsiveness, reliability and interpretability of the Dutch proxy version of RECAP.

Methods
A prospective validation study was conducted in children (aged &lt; 12 years) with AD and their caregivers (in a Dutch tertiary hospital). At three timepoints (T0 = baseline; T1 = after 1–7 days; T2 = after 4–8 weeks) RECAP and multiple reference instruments were completed by caregivers of child patients. Single- and change-score validity (responsiveness) were tested with a priori hypotheses on correlations with reference instruments. Intraclass correlation coefficients (ICCagreement) and standard error of agreement (SEMagreement) were reported. Bands for perceived eczema control were proposed. The smallest detectable change (SDC) and minimally important change (MIC) were determined. Two anchor-based methods based on receiver operating characteristic curve (ROC) and predictive modelling were used to determine the MIC.

Results
A total of 231 children with AD and their caregivers participated. Of our a priori hypotheses for single-score and change-score validity, 77% and 80% were confirmed, respectively. A stronger correlation than hypothesized was found for all rejected hypotheses.
Excellent reliability was found (ICCagreement = 0.94, 95% confidence interval 0.90–0.96). The SEMagreement was 1.9 points. The final banding was 0–1 (completely controlled), 2–7 (mostly controlled), 8–12 (moderately controlled), 13–18 (a little controlled) and 19–28 (not at all controlled). A cutoff point of ≥ 8 was selected to identify children whose AD is not under control. The SDC was 5.3 and the MIC values were 1.5 and 3.6 for the ROC and predictive modelling approaches, respectively. No floor or ceiling effects were observed.

Conclusions
The proxy version of RECAP is a valid, reliable and responsive measurement instrument for measuring eczema control in children with AD. An improvement of ≥ 6 points can be regarded as a real and important change in children with AD.
The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3
Authors: Moreno-Manuel Ana I , Macías Álvaro , Cruz Francisco M , Gutiérrez Lilian K , Martínez Fernando , González-Guerra Andrés , Martínez Carrascoso Isabel , Bermúdez-Jimenez Francisco José , Sánchez-Pérez Patricia , Vera-Pedrosa María Linarejos , Ruiz-Robles Juan Manuel , Bernal Juan A , Jalife José 
Published: January 2024

Abstract

Aims
Short QT syndrome type 3 (SQTS3) is a rare arrhythmogenic disease caused by gain-of-function mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2.1. We used a multidisciplinary approach and investigated arrhythmogenic mechanisms in an in-vivo model of de-novo mutation Kir2.1E299V identified in a patient presenting an extremely abbreviated QT interval and paroxysmal atrial fibrillation.

Methods and results
We used intravenous adeno-associated virus-mediated gene transfer to generate mouse models, and confirmed cardiac-specific expression of Kir2.1WT or Kir2.1E299V. On ECG, the Kir2.1E299V mouse recapitulated the QT interval shortening and the atrial-specific arrhythmia of the patient. The PR interval was also significantly shorter in Kir2.1E299V mice. Patch-clamping showed extremely abbreviated action potentials in both atrial and ventricular Kir2.1E299V cardiomyocytes due to a lack of inward-going rectification and increased IK1 at voltages positive to −80 mV. Relative to Kir2.1WT, atrial Kir2.1E299V cardiomyocytes had a significantly reduced slope conductance at voltages negative to −80 mV. After confirming a higher proportion of heterotetrameric Kir2.x channels containing Kir2.2 subunits in the atria, in-silico 3D simulations predicted an atrial-specific impairment of polyamine block and reduced pore diameter in the Kir2.1E299V-Kir2.2WT channel. In ventricular cardiomyocytes, the mutation increased excitability by shifting INa activation and inactivation in the hyperpolarizing direction, which protected the ventricle against arrhythmia. Moreover, Purkinje myocytes from Kir2.1E299V mice manifested substantially higher INa density than Kir2.1WT, explaining the abbreviation in the PR interval.

Conclusion
The first in-vivo mouse model of cardiac-specific SQTS3 recapitulates the electrophysiological phenotype of a patient with the Kir2.1E299V mutation. Kir2.1E299V eliminates rectification in both cardiac chambers but protects against ventricular arrhythmias by increasing excitability in both Purkinje-fiber network and ventricles. Consequently, the predominant arrhythmias are supraventricular likely due to the lack of inward rectification and atrial-specific reduced pore diameter of the Kir2.1E299V-Kir2.2WT heterotetramer.
Lipoprotein(a) and cardiovascular disease: sifting the evidence to guide future research
Authors: Kamstrup Pia R , Neely R Dermot G , Nissen Steven , Landmesser Ulf , Haghikia Arash , Costa-Scharplatz Madlaina , Abbas Cheryl , Nordestgaard Børge G 
Published: January 2024

AbstractLipoprotein(a) (Lp(a)) is a genetically determined causal risk factor for cardiovascular disease including coronary heart disease, peripheral arterial disease, ischaemic stroke, and calcific aortic valve stenosis. Clinical trials of specific and potent Lp(a)-lowering drugs are currently underway. However, in clinical practice, widespread assessment of Lp(a) is still lacking despite several guideline recommendations to measure Lp(a) at least once in a lifetime in all adults to identify those at high or very high risk due to elevated levels. The present review provides an overview of key findings from observational and genetic Lp(a) studies, highlights the main challenges in observational Lp(a) studies, and proposes a minimum set of requirements to enhance the quality and harmonize the collection of Lp(a)-related data. Adherence to the recommendations set forth in the present manuscript is intended to enhance the quality of future observational Lp(a) studies, to better define thresholds for increased risk, and to better inform clinical trial design. The recommendations can also potentially assist in the interpretation and generalization of clinical trial findings, to improve care of patients with elevated Lp(a) and optimize treatment and prevention of cardiovascular disease.
P2X7 receptor inhibition prevents atrial fibrillation in rodent models of depression
Authors: Ye Tianxin , Zhou Yunping , Yang Jinxiu , Yu Fangcong , Song Zhuonan , Shi Jiaran , Wang Longbo , Huang Zhouqing , Yang Bo , Wang Xingxiang 
Published: January 2024

Abstract

Aims
Depression, the most prevalent psychiatric disorder, is associated with the occurrence and development of atrial fibrillation (AF). P2X7 receptor (P2X7R) activation participates in the development of depression, but little attention has been given to its role in AF. This study was to investigate the effects of P2X7R on AF in depression models.

Methods and results
Lipopolysaccharide (LPS) and chronic unpredictable stress (CUS) were carried out to induce depression in rodents. Behavioural assessments, atrial electrophysiological parameters, electrocardiogram (ECG) parameters, western blot, and histology were performed. Atrial fibrillation inducibility was increased in both LPS- and CUS-induced depression, along with the up-regulation of P2X7R in atria. CUS facilitated atrial fibrosis. CUS reduced heart rate variability (HRV) and increased the expression of TH and GAP43, representing autonomic dysfunction. Down-regulation of Nav1.5, Cav1.2, Kv1.5, Kv4.3, Cx40, and Cx43 in CUS indicated the abnormalities in ion channels. In addition, the expression levels of TLR4, P65, P-P65, NLRP3, ASC, caspase-1, and IL-1β were elevated in depression models. Pharmacological inhibitor (Brilliant Blue G, BBG) or genetic deficiency of P2X7R significantly mitigated depressive-like behaviours; ameliorated electrophysiological deterioration and autonomic dysfunction; improved ion channel expression and atrial fibrosis; and prevented atrial NLRP3 inflammasome activation in the pathophysiological process of AF in depression models.

Conclusion
LPS or CUS induces AF and promotes P2X7R-dependent activation of NLRP3 inflammasome, whereas pharmacological P2X7R inhibition or P2X7R genetic deficiency prevents atrial remodelling without interrupting normal atrial physiological functions. Our results point to P2X7R as an important factor in the pathology of AF in depression.
Effect of a case-capped, fee-for-service payment mechanism on accessibility and affordability of health care
Authors: Cielo Bernardo , Santillan Melanie , de Claro Vergil 
Published: January 2024

Abstract
In response to a government audit report in 2021, the Philippine health insurance system transitioned its case-based payment system back into a fee-for-service model capped at individual case rates. This commentary discusses the adverse effects of this policy on health care accessibility and affordability in the country. A rapid review of data shows that it may have resulted in delayed insurance payments, increased denial rates, and reduced coverage, and weakened the strategic purchasing capacity of public health insurance, hugely affecting vulnerable populations and public health care facilities. The commentary calls for a reconsideration of the policy and emphasizes the importance of aligning financial auditing procedures with the needs of health-financing institutions. It advocates for a transformation of audits, moving beyond their traditional role as compliance checks, to become valuable tools supporting a nation's health care purchasing strategies, ultimately benefiting both health care providers and the broader public.
Quantitative criticalism for social justice and equity-oriented communication research
Authors: Kim Youllee 
Published: January 2024

Abstract
An increasing number of communication researchers have noted the potential of quantitative criticalism (QuantCrit) or the use of quantitative approaches to pursue social justice and equity agenda. Nonetheless, how to achieve the goals and ideals of QuantCrit in communication studies still largely remains uncharted terrain. This article offers five concrete suggestions for how researchers can bring critical consciousness to quantitative communication research: (a) broadening and diversifying the scope of communication research, (b) (re)framing research questions with a social justice orientation, (c) critiquing dominant narratives and centering the counternarratives, (d) incorporating intersectionality to address marginalization, and (e) employing statistical methods that illuminate interdependence, systems, and power dynamics. This article seeks to enrich the discussion on ways to embrace QuantCrit in communication research to revitalize perspectives and means for identifying and addressing inequalities, and eventually to advance transformative scholarship.
Adapting national data systems for donor transition: comparative analysis of experience from Georgia and China
Authors: Chikovani Ivdity , Soselia Giorgi , Huang Aidan , Uchaneishvili Maia , Zhao Yingxi , Cao Chunkai , Lyu Mohan , Tang Kun , Gotsadze George 
Published: January 2024

Abstract
Health management information systems (HMISs) are essential in programme planning, budgeting, monitoring and evidence-informed decision-making. This paper focuses on donor transitions in two upper-middle-income countries, China and Georgia, and explores how national HMIS adaptations were made and what facilitated or limited successful and sustainable transitions. This comparative analytical case study uses a policy triangle framework and a mixed-methods approach to explore how and why adaptations in the HMIS occurred under the Gavi Alliance and the Global Fund–supported programmes in China and Georgia. A review of published and grey literature, key informant interviews and administrative data analysis informed the study findings. Contextual factors such as the global and country context, and health system and programme needs drove HMIS developments. Other factors included accountability on a national and international level; improvements in HMIS governance by establishing national regulations for clear mandates of data collection and reporting rules and creating institutional spaces for data use; investing in hardware, software and human resources to ensure regular and reliable data generation; and capacitating national players to use data in evidence-based decision-making for programme and transition planning, budgeting and outcome monitoring. Not all the HMIS initiatives supported by donors were sustained and transitioned. For the successful adaptation and sustainable transition, five interlinked and closely coordinated support areas need to be considered: (1) coupling programme design with a good understanding of the country context while considering domestic and external demands for information, (2) regulating appropriate governance and management arrangements enhancing country ownership, (3) avoiding silo HMIS solutions and taking integrative approach, (4) ensuring the transition of funding onto domestic budget and enforcing fulfilment of the government’s financial commitments and finally (5) investing in technologies and skilled human resources for the HMIS throughout all levels of the health system. Neglecting any of these elements risks not delivering sustainable outcomes.