bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of KRAS Mutation and Primary Tumor Location with Recurrence in Colorectal Liver Metastases Undergoing Radiofrequency Ablation
Authors: Jiang Binbin , Wang Jichen , Yan Kun , Zhang Zhongyi , Wang Song , Wu Wei , Yang Wei , Chen Minhua 
Published: November 2023

Abstract
Purpose
KRAS mutation and Primary tumor location are important factors affecting the prognosis of patients with colorectal liver metastases (CLM). However, some studies showed there may be an interaction between the two. We sought to investigate the association of KRAS mutations with recurrence in patients with CLM undergoing radiofrequency ablation (RFA) according to the primary tumor location.
Methods
CLM patients with a known KRAS gene status who underwent RFA were enrolled from January 1, 2012 to December 31, 2018. Clinicopathological data, recurrence, and survival dates were evaluated retrospectively.
Results
164 patients (mean age: 58.0 ± 9.8 years, range: 34–83) who underwent percutaneous RFA of 325 CLM (mean sizes: 2.2 ± 1.0 cm, range: 0.7–5.0) were included in the study; 89 (54.3%) cases were KRAS wild-type and 75 (45.7%) cases had KRAS mutation. Of the patients, 22.0% (36 of 164) had local tumor progression (LTP), and 23 of 75 patients (30.7%) in the KRAS mutation group had LTP, which was significantly higher than in patients with KRAS wild-type (13 of 89 patients (14.6%)) (p = 0.013). Of the 126 (76.8%) patients with recurrence after RFA, 101 (61.6%) had intrahepatic recurrence, while 88 (53.7%) had extrahepatic recurrence. Among patients with left-sided colorectal cancer (CRC), intrahepatic recurrence rates were higher among patients with KRAS mutation than among patients with the wild type KRAS (77.2% vs 52.5%, p = 0.003); the median intrahepatic recurrence-free survival (RFS) was worse in KRAS mutation patients (25 vs 15 months, P = 0.007). In patients with right-sided CRC, there was no significant difference in intrahepatic recurrence between the KRAS wild-type and KRAS mutation groups (P＞0.05). Further, KRAS gene had no impact on extrahepatic recurrence irrespective of the primary tumor site. In the multivariable analysis, KRAS mutation and positive lymph nodes remained independently associated with a worse RFS among patients (HR: 1.526, 95% confidence interval [CI]: 1.056–2.207, P = 0.025; HR: 1.602, 95% CI: 1.008–2.545, P = 0.046).
Conclusions
KRAS status is associated with recurrence of CLM after RFA depending on primary tumor location.
Investigation on residual stress formation mechanism considering cutting energy in milling of aluminum alloy
Authors: Zheng Youyi , Yuzhao Tian , Ma Junjin , Zhang Faping , Cui Xiaobin , Ren Lei 
Published: November 2023

Abstract

Aluminum alloy has the characteristics of good corrosion resistance and high strength, so aluminum alloy workpiece is widely used in the aerospace field. However, in milling, the surface of the aluminum alloy workpiece generates residual stress due to the coupling of force and heat, which seriously affects the fatigue performance of the workpiece. To investigate the residual stress formation mechanism, an analyzed model of machining-induced residual stress considering energy conversion in milling process was proposed. In this process, the milling force prediction model is established. Then, an effective cutting work model is established based on the milling force model. After that, the strain energy density of the machined surface layer was analyzed and the strain energy solution model was established. Subsequently, the prediction models of mechanical stress, thermal stress and residual stress are established respectively, and the residual stress data are brought into the strain energy model to obtain the strain energy. Afterwards, the functional transformation relationship between effective cutting work and strain energy storage per unit time is analyzed. Finally, several milling experiments were carried out to verify the predicted milling force and residual stress. Experimental results show that errors between the predicted results and the experimental results are about 5 % and 15 %, respectively, and the functional transformation results show that the stored strain energy per unit time increases with the increase of the effective cutting work.
Autism and Suicide: Strategies to Dovetail Emerging Evidence in Child and Adolescent Suicide Risk Assessments
Authors: Gupta Mayank , Gupta Nihit , Petti Theodore 
Published: November 2023

Abstract
Background: This narrative review provides readers with a greater awareness of the increasing prevalence of diagnosed autism spectrum disorder (ASD) in psychiatric clinical settings and the high risk that ASD and autistic traits in the population place the affected individuals at heightened risk for suicidality and suicide.
Methods: It represents a comprehensive, systematic literature review. supplemented with reverse citations to assure updated information. By title and abstract 456 articles were identified 456 and 71 articles met the inclusion criteria. Out of those, 50 articles were used for initial review and 15 were added later, manually or through reverse citations.
Results: Results indicate that associated suicidal thoughts and behaviors (STB) with ASD, many concomitants comorbid mental health conditions ASD, and suicide risk factors that overlap with ASD symptoms are not clearly understood. Higher rates of STB and suicide have been identified across the age spectrum with ASD/high autistic traits compared to those from the general population in age/sex-matched comparison groups. Increased risk of STB in higher functioning ASD is emphasized. Interpersonal conflict and depression are significant risk factors as are comorbid borderline personality, bipolar disorder, anxiety, and obsessive-compulsive disorders.
Conclusions: Multiple diagnostic challenges are considered that support the need for more focused research in this area, better, more ASD-related screening instruments that address the unique features of ASD-related psychopathology, and improved training for clinicians in screening and preventive efforts for enhanced competence and greater comfort in dealing with STB in those with autistic traits and ASD.
Spatiotemporal changes of land use in response to runoff and sediment yield for environmental sustainability in the upper Blue Nile Basin, Oromiyaa, Ethiopia
Authors: Tumsa Bekan Chelkeba , Feyessa Fekadu Fufa , Tullu Kiyya Tesfa , Guder Abebe Chala 
Published: November 2023

Abstract

Modeling and mapping hydrological responses of runoff and sediment yield to spatiotemporal land use changes are crucial concerning environmental sustainability. The research was aimed at quantifying the spatiotemporal effects of land use on runoff and sediment yields using three land use satellite images and the SWAT+ model. The increase in agriculture, settlement, and decreasing forest goes to the possibility of increasing sediment yield and runoff by 53.2 and 56.5%, respectively, affecting ecosystems. The areas vulnerable to high runoff were found at the lower and middle reaches with the annual average runoff of 10,825.1, 11,972.9, and 13,452 mm for each respective scenario. On the other hand, most of the soil erosion-prone areas designated as severe in the second and third scenarios were covered by agriculture and shrubland, with annual sediment yields of 301.5 and 267.5 tons, respectively. Deforestation for agricultural expansion has a significant role in environmental degradation, as forests play an irreplaceable role in ecological resilience. Generally, the dominant land uses that instigate soil erosion, runoff, and sediment yield are agriculture, shrubland, and deforestation. The simulation of runoff and sediment yield in response to land use change using the SWAT+ model is more scientifically reliable and acceptable.
Estabilidad transversal de buques pesqueros con trimado libre
Authors: Valerio Mena Lenin J.C. , Rodríguez Castillo Claudio A. 
Published: November 2023

Gran parte de los accidentes con embarcaciones pesqueras se deben a problemas de estabilidad transversal durante la faena de pesca, en la cual la embarcación se escora grandes ángulos, y muchas veces al no lograr recuperarse, zozobra. En los estudios y peritajes llevados a cabo por las Aseguradoras generalmente se llega a la conclusión de que la embarcación superó su límite de estabilidad. Este límite de estabilidad en algunos casos puede no haberse evaluado correctamente. En este trabajo se discute la eficiencia del cálculo de estabilidad estática transversal usado en el diseño de buques y embarcaciones pesqueras de la flota peruana, basados en los diagramas de curvas cruzadas de estabilidad tradicional que condiciona el trimado de la embarcación a permanecer inalterado. Los calculos realizados por el método tradicional son comparados con otros realizados utilizando un método de cálculo de trimado libre, basado en el concepto del equilibrio hidrostático de cuerpos flotantes.
Se presenta el método de cálculo con trimado libre incluyendo un caso ilustrativo.
Sobre llovido, mojado. Pandemia y violencias en poblaciones vulnerables en el Área Reconquista (Provincia de Buenos Aires)
Authors: Caravaca Evangelina , Garriaga Zucal José , Mancini Inés 
Published: November 2023

La pandemia del COVID-19 produjo enormes transformaciones a lo largo de todo el mundo; las mismas son aún difíciles de describir y comprender. En la Argentina, el impacto de la crisis económica, social y sanitaria agudizó las desigualdades. En esta investigación nos propusimos estudiar si más allá del agravamiento de las desigualdades que produjo la pandemia, se habían modificado los mapas de las violencias en la Argentina. Para ello, trabajamos sobre los criterios de legitimidad de ciertas violencias y las intensidades durante la pandemia.
Con este objetivo, analizaremos las diferentes formas de violencias en un área geográfica vulnerable en el partido de General San Martín (Buenos Aires, Argentina), específicamente el Área Reconquista. Nos interesa dar cuenta, al tiempo que problematizar, la geografía de las violencias en su relación con la vulnerabilidad y en especial el accionar de las fuerzas de seguridad en estas dinámicas sociales. Los datos cualitativos y cuantitativos que se retoman en este artículo son el producto de una investigación realizada entre febrero y agosto del 2021 que buscó reflexionar sobre mutaciones y continuidades de las manifestaciones violentas en estos espacios como resultado de la emergencia sanitaria producida por el COVID-19. Entre otras tareas de investigación, se realizaron sesenta entrevistas en profundidad a vecinos, fuerzas de seguridad y funcionarios del área Reconquista del partido de General San Martín (provincia de Buenos Aires).
A hybrid online and offline teaching model of professional English based on empirical modal decomposition method empowered by digital technology
Authors: Wang Xueqin 
Published: November 2023

Abstract
With the rapid development of artificial intelligence digital technology, its related techniques have penetrated and been applied to the education industry and field. In this paper, we address the limitations of CEEMD in processing student performance prediction data and combine the hybrid gray wolf optimization algorithm with the minimum gating unit recurrent neural network to establish an English performance prediction model by simulating the leadership, hunting, and ranking mechanisms of the gray wolf population, as a way to complete the optimization of EMD limitations. Then, using the empirical modal decomposition method and other auxiliary methods, we conducted an experimental study on the online and offline “hybrid” teaching model for two classes of English majors in the School of Foreign Languages of Huanghe Science and Technology University in 2021 and passed equal-group pre-test and t-test. The results showed that the significance level α of English performance in class B was 0.10, and since the probability value P was less than 0.10, it was considered that there was a significant difference between the two overall means, i.e., there was a significant difference between the overall means of the improvement in the performance of class B and class A. The overall performance of class B students was significantly higher than that of class A. This study combines online and offline teaching modes through digital technology to promote the use of online and offline “hybrid” teaching modes in higher education institutions, which is very important.
Young adult substance use following involuntary job loss
Authors: Jolly Nicholas A. , Davis Gwendolyn 
Published: November 2023

Abstract
This paper uses data from the Panel Study of Income Dynamics to study the relationship between job displacement and substance use among young adults. Results show that displacement is associated with increases in the probability of smoking cigarettes and drinking and the intensity of consuming alcohol and marijuana. Men, whites, and those who live with family/friends at the time of displacement are more likely to use hard drugs after job loss. Findings suggest that government policy designed to aid displaced workers should contain provisions to anticipate and respond to substance use disorders that may arise, particularly among younger job losers.
Investigation of Hybrid Lap Welds of TI6AL4V and Stainless Steel with Bronze Interlayer
Authors: Chmelíčková Hana , Havelková Martina , Hrubantová Aneta , Jílek Vlastimil , Václavek Lukáš , Ingr Tomáš 
Published: November 2023

Abstract
Welding of the austenitic stainless steel AISI 304 and Ti6Al4V is complicated by hard and brittle intermetallic compound formation. In this contribution, we study a laser welding method that partially overcomes this problem using interlayer. Bronze foil (CuSn6) of thickness 100 µm and 200 µm was inserted between steel and titanium sheets and lap welds were realized on pulsed Nd:YAG laser. Representative samples were investigated by nanohardness measurement, SEM/EDS, and XRD analysis to detect the localization of the intermetallic phases. The macrostructure of the weld cross sections was displayed by optical and digital microscopy. The nano-hardness test revealed the presence of very hard intermetallic mainly around the interface between the fusion zone and bottom metal sheet. EDS mapping displayed the main elements Fe, Cr, Cu and Ti distribution in the fusion zone, EDS line scanning detected elements‘ signals in the diagonal and horizontal directions. XRD analysis revealed expected intermetallic compounds FeTi and CuTi2 and solid solution Cu0.8Fe0.2.
Subtle Trichilemmal Carcinoma of Neck Initially Misdiagnosed as Benign Cyst and Ultimately Treated with Mohs Micrographic Surgery
Authors: Shahzeidi Parastou , Fezza Reed , Green William 
Published: November 2023

Abstract
Trichilemmal carcinoma(TC) is an exceeding rare malignant adnexal lesion, originating from hair follicle cells. Given its rarity, widely variable clinical presentation, and often non-specific appearance, TC is commonly misdiagnosed as a number of different lesions, some benign, which can lead to delays in treatment and suboptimal patient outcomes. In this report, we discuss a 65-year-old man with a neck lesion originally misdiagnosed as benign and later found to be TC all along. We also discuss several treatment options, and ultimately favor Mohs Micrographic Surgery (MMS) as the preferred treatment for TC in this case.
Methotrexate Monitoring in Dermatology: A Follow-Up Retrospective Cohort Study
Authors: Mark Erica , Vittitow Stephany , Zufall Alina , Nguyen Joseph , Flowers Richard 
Published: November 2023

Introduction: There have been no large-scale studies looking at the efficacy and safety of methotrexate. Prior research by our team investigated whether certain monitoring practices were associated with lab abnormalities resulting in clinically relevant events (CREs) within the first 90 days of methotrexate treatment and concluded that dermatologists may consider postponing lab monitoring until 15 days after methotrexate initiation in patients without concerning baseline disease. This follow-up study was performed to determine when within the first 90 days of treatment CREs were most likely to occur and to define the specific numeric values at which abnormal labs resulted in a CRE.
Methods: The medical records of 243 dermatology patients were retrospectively reviewed.
Results: Week 11 had the highest percentage of CREs (11.1%, p=0.00003), with slight peaks at weeks 2 and 5. ALT (22%) and AST (27%) were the most commonly abnormal labs, and elevated ALT (p=0.00087) and AST (p=0.03) values were significantly higher in CREs.
Discussion: This data suggests that lab frequency can be reduced within the first few months; optimal timing of lab draws may be around weeks 2-5 and 11-12. In summary, we found that 1) abnormal labs most frequently led to a CRE at week 11 of monitoring, 2) ALT and AST were the most frequently abnormal labs, and 3) abnormal ALT and AST values were significantly higher in patients with CREs. This study provides valuable insight into an understudied dermatologic topic and hopefully will inform clinicians regarding methotrexate laboratory monitoring and spur further investigation.
A US Claims Database Analysis Estimating Risk of All-Cause Mortality in Patients with Generalized Pustular Psoriasis
Authors: Gottlieb Alice , Zimmermann Thomas , Lavasani Layla , Semeco Juan , Lebwohl Mark 
Published: November 2023

Introduction: Generalized pustular psoriasis (GPP) is a rare, chronic, neutrophilic skin disease characterized by recurring flares of widespread erythema, edema, coalescing pustules, and possible systemic symptoms. GPP flares may require hospitalization and can be life-threatening. There are limited data describing the mortality burden of GPP in the US. This study compared all-cause mortality among patients with GPP with matched patients with plaque psoriasis (PsO), and the general population without GPP or PsO.
Methods: Inovalon Insights real-world claims data were used to identify 5 cohorts (All GPP, Comorbid GPP+PsO, GPP Only, PsO Only, General Population) based on the International Classification of Diseases, Tenth Revision (ICD-10) diagnosis codes from Jan 1, 2016, to Dec 31, 2019. GPP Only, PsO Only, and Comorbid GPP+PsO were mutually exclusive. All GPP included GPP Only (excluding PsO) and Comorbid GPP+PsO. General Population comprised qualifying patients without a medical claim for GPP or PsO during pre- and post-index periods. All-cause mortality was assessed both 365 days post-index diagnosis and during a maximum follow-up period (until study period ended or patient experienced an event). Greedy caliper propensity score matching was used to match GPP patients 1:2 to PsO and General Population using index year, age, gender, insurance type, region, and Charlson Comorbidity Index (CCI). All-cause mortality risk was assessed using Cox proportional hazard models.
Results: Patients were primarily female and commercially insured. The GPP Only cohort was older at index and had higher CCI scores than PsO Only and General Population (p<0.001), highlighting the higher severity of GPP. At 365 days follow-up, All GPP had a significantly higher mortality risk than General Population (HR 4.93, 95% CI 2.24-10.88) and PsO Only (HR 2.31, 95% CI 1.32-4.04). GPP+PsO had a significantly higher mortality risk than PsO Only (HR 2.67, 95% CI 1.15-6.20). At 365 days follow-up, GPP Only had a numerically higher mortality risk than PsO; risk was significantly higher at the later timepoint. At maximum follow-up, the mortality risk for All GPP was almost 4 times higher than General Population (HR 3.98, 95% CI 2.92-5.43) and 1.5 times higher than PsO Only (HR 1.49, 95% CI 1.20-1.85). In GPP+PsO and GPP Only, the mortality risk was almost 1.5 times the risk of PsO Only (HR 1.41, 95% CI 1.05-1.90; HR 1.49, 95% CI 1.10-2.03); all comparisons at maximum follow-up were statistically significant.
Conclusion: This study characterizing all-cause mortality in patients with GPP demonstrated a higher risk of mortality in GPP than matched PsO and General Population cohorts. These results fill a gap in the existing literature and reinforce the need for awareness of the mortality burden and the comorbidity burden in GPP
PASI Improvement in the First 12 weeks from the Phase 3 VOYAGE 1, VOYAGE 2, ORION and ECLIPSE Guselkumab Clinical Trials
Authors: Abbarin Nastaran , Papp Kim , Vender Ronald , Langley Richard , Ho Vincent , Park-Wyllie Laura , Miller Megan , You Yin , Yang Ya-Wen 
Published: November 2023

Background VOYAGE 1, VOYAGE 2, ORION, and ECLIPSE are Phase 3, double-blind trials of guselkumab 100 mg s/c at Weeks 0, 4, 12, then Q8W in moderate to severe plaque psoriasis. VOYAGE 1 and VOYAGE 2 included placebo and active comparator groups, ORION was placebo controlled, and ECLIPSE included an active comparator control group. The objective of this analysis was to evaluate PASI improvement among subjects treated with guselkumab over the induction phase of treatment.
Methods Medan (interquartile) PASI improvements were evaluated at W4, W8, and W12. Analyses were performed using treatment failure rules, which considered non-responders as those who discontinued due to lack of efficacy or worsening of PsO, or use of a protocol prohibited PsO treatment. Mean PASI improvement responses were also assessed.
Results VOYAGE 1 included 329 subjects randomized to receive guselkumab, while VOYAGE 2, ORION and ECLIPSE trials included 496, 62, and 534 subjects randomized to guselkumab, respectively. At W4, median PASI improvements were 56.70%, 56.85%, 37.15% and 67.50% for VOYAGE 1, VOYAGE 2, ORION and ECLIPSE, respectively. At W8, median PASI improvements were 82.60%, 85.00%, 78.55% and 89.70% for the studies, respectively. Similarly, at W12, median PASI improvements were 92.50%, 91.95%, 93.20% and 95.70%, respectively.
Conclusions Median PASI improvements of approximately 60% were observed following 1st dose of guselkumab at W4, except ORION, and increased to greater than 90% after the 2nd dose of guselkumab at W12. This analysis provides information on the onset of action of guselkumab during the first few months of treatment.