bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projection of the combination of land use and climate change impacts on runoff in the Bojnourd catchment under CMIP6 Scenarios
Authors: Hossainzadeh Ahmad , Kashki Abdolreza , Karami Mokhtar , Sabbaghian Reza Javidi 
Published: November 2023

Abstract
Climate change and land use changes have a significant impact on the hydrological cycle in river basins and water resources in arid and semi-arid regions of the world. Evaluating these changes is necessary to reduce their effects on the basin and develop a suitable strategy to minimize their impacts. Using the LARS-WG and SWAT combined model, this study evaluated the simultaneous effects of land use changes and climate change on the hydrological response of the catchment in the Bojnourd catchment in North Khorasan province, Iran. First, the changes in climate parameters during the years 2049-2020 in the two synoptic stations of Bojnourd and Asadli were investigated in the conditions of climate change using SSP245 scenarios as the medium scenario and SSP585 (pessimistic scenario) from the sixth IPCC CMIP6 report. SUFI2 algorithm is used in SWAT-CUP software to validate and confirm the SWAT model. In the calibration stage, the Nash-Sutcliffe index (NS) coefficient for the basin was 0.59 and in the confirmation stage, this index was 0.50 percent. In this research, land use changes were analyzed and predicted using ENVI software and the CA-Markov model for the years 2001, 2019, and 2040. The Kappa coefficient has been used to determine the accuracy of the land use map and its value for 2001 and 2001. 2019 are 0.91 and 0.95 percent respectively. Human-made land use changes accounted for the most land use changes between 2001 and 2040, which almost tripled in about 40 years. Also, the ratio of pasture has decreased from 61% to about 50%. On the other hand, the share of barren land will increase from 22% to about 27% by 2040. However, the precipitation will be different in Asadli and Bojnourd stations because the first shows a decrease and the second shows a very small amount of increase. The results of the SWAT model showed that the combined effect of both climate change factors and land use changes will reduce the runoff of the basin during the coming period so that the average monthly discharge at the outlet of the basin from 1.26 cubic meters per second in the base period to about 1.04 cubic meters per second (17.5 percent) will decrease in the coming period. The biggest decrease in the ssp585 scenario, as a pessimistic scenario without calculating the effect of land use changes in 2040 and only examining the effect of climate changes in the future period, the basin runoff will decrease by 0.9 cubic meters per second (28.5%). In fact, in both scenarios, the watershed runoff decreases, while the effect of land use change increases the watershed runoff, and this increase is less than the effect of climate change in the watershed.
Optimizing DevOps Enablers for Quantum Software Development
Authors: AlSanad Abeer , Akbar Muhammad 
Published: November 2023

Abstract
In the context of quantum software development, DevOps for quantum software development for quantum software development emerges as a crucial set of collaborative practices geared towards automating the seamless delivery of software updates, all while reducing development cycles and ensuring high-quality products. Yet, the integration of development and operational teams poses unique challenges, demanding the amalgamation of diverse processes, tools, and skill sets. This study undertakes the task of crafting a taxonomy of quantum DevOps for quantum software development for quantum software development best practices using a multicriteria decision process. Through a systematic literature review, we identify and document these best practices, complemented by industry insights gathered via a questionnaire survey. Employing the fuzzy-AHP technique, we prioritize these practices to empower organizations to assess and enhance their quantum DevOps for quantum software development for quantum software development operations, paving the way for more efficient and quality-focused quantum software development.
Developing an optimal plan to improve irrigation efficiency using a risk-based central force algorithm
Authors: Jiang Junmin , Chen Shi 
Published: November 2023

Abstract
Losses in surface irrigation include deep percolation and runoff, which is one of the ways to increase the efficiency of furrow irrigation, using a closed-end mode in irrigation systems. This research was conducted to evaluate the effects of geometrical variables (slope and length of furrow) and flow control (inflow rate and cut-off time) on application efficiency (AE) and the uniformity of water distribution in a closed-end furrow irrigation system. The length, slope, inflow rate, and cut-off time are considered as the decision-making variables for developing the multi-objective genetic algorithm based on the non-dominated sorting. For this purpose, three irrigation furrows with the closed-end system were considered. The optimization algorithm for calculating the objective functions involves maximizing the minimum water depth and minimizing the infiltration depth in a modeling loop. The optimization algorithm was linked to the WinSRFR software to calculate the objective functions. The results showed that the best combination of inflow rate and the cut-off time for 75 mm of required water depth was 1.9 L/s/m and 150 min, respectively, which increased AE and distribution uniformity to 79 and 78%. Furthermore, the AE in the closed-end furrow irrigation system is higher (30–50%) than the open-end method in different scenarios.
Identification of Key Prognostic Alternative Splicing Events of Costimulatory
Molecule-Related Genes in Colon Cancer
Authors: Ding Hao , Shi Huiwen , Chen Weifeng , Liu Zhisheng , Yang Zhi , Li Xiaochuan , Qiu Zhichao , Zhuo Hongqing 
Published: November 2023

Objective:
This study aimed to explore the key alternative splicing events in costimulatory
molecule-related genes in colon cancer and to determine their correlation with prognosis.

Methods:
Gene expression RNA-sequencing data, clinical data, and SpliceSeq data of colon
cancer were obtained from The Cancer Genome Atlas. Differentially expressed alternative
splicing events in genes were identified, Followed by correlation analysis of genes corresponding
to differentially expressed alternative splicing events with costimulatory molecule-related
genes. Survival analysis was conducted using differentially expressed alternative splicing
events in these genes and a prognostic model was constructed. Functional enrichment, proteinprotein
interaction network, and splicing factor analyses were performed.

Results:
In total, 6504 differentially expressed alternative splicing events in 3949 genes were
identified between tumor and normal tissues. Correlation analysis revealed 3499 differentially
expressed alternative splicing events in 2168 costimulatory molecule-related genes. Moreover,
328 differentially expressed alternative splicing events in 288 costimulatory molecule-related
genes were associated with overall survival. The prognostic models constructed using these
showed considerable power in predicting survival. The ubiquitin A-52 residue ribosomal protein
fusion product 1 and ribosomal protein S9 were the hub nodes in the protein-protein interaction
network. Furthermore, one splicing factor, splicing factor proline and glutamine-rich,
was significantly associated with patient prognosis. Four splicing factor-alternative splicing
pairs were obtained from four alternative splicing events in three genes: TBC1 domain family
member 8 B, complement factor H, and mitochondrial fission 1.

Conclusion:
The identified differentially expressed alternative splicing events of costimulatory
molecule-related genes may be used to predict patient prognosis and immunotherapy responses
in colon cancer.
Neuroimaging Genetics and Network Analysis in Alzheimer’s Disease
Authors: Moon Seok Woo 
Published: November 2023

Abstract:
The issue of the genetics in brain imaging phenotypes serves as a crucial link between
two distinct scientific fields: neuroimaging genetics (NG). The articles included here provide solid
proof that this NG link has considerable synergy. There is a suitable collection of articles that offer
a wide range of viewpoints on how genetic variations affect brain structure and function. They
serve as illustrations of several study approaches used in contemporary genetics and neuroscience.
Genome-wide association studies and candidate-gene association are two examples of genetic techniques.
Cortical gray matter structural/volumetric measures from magnetic resonance imaging (MRI)
are sources of information on brain phenotypes. Together, they show how various scientific
disciplines have benefited from significant technological advances, such as the single-nucleotide
polymorphism array in genetics and the development of increasingly higher-resolution MRI imaging.
Moreover, we discuss NG’s contribution to expanding our knowledge about the heterogeneity
within Alzheimer’s disease as well as the benefits of different network analyses.
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease:
Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Authors: R Herman , A Janez , DP Mikhailidis , P Poredos , A Blinc , M Sabovic , K Bajuk Studen , GH Schernthaner , P Anagnostis , PL Antignani , M Jensterle 
Published: November 2023

Abstract:
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised
for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in
the development of the CV system as well as in the complex molecular network that regulates cardiac
and endothelial structure and function. A considerable correlation between GH levels and CV mortality
exists even among individuals in the general population without a notable deviation in the GHIGF-
1 axis functioning. In addition, over the last decades, evidence has demonstrated that pathologic
conditions involving the GH-IGF-1 axis, as seen in GH excess to GH deficiency, are associated with
an increased risk for CV morbidity and mortality. A significant part of that risk can be attributed to
several accompanying comorbidities. In both conditions, disease control is associated with a consistent
improvement of CV risk factors, reduction of CV mortality, and achievement of standardised
mortality ratio similar to that of the general population. Data on the prevalence of peripheral arterial
disease in patients with acromegaly or growth hormone deficiency and the effects of GH and IGF-1
levels on the disease progression is limited. In this review, we will consider the pivotal role of the
GH-IGF-1 axis on CV system function, as well as the far-reaching consequences that arise when disorders
within this axis occur, particularly in relation to the atherosclerosis process.
Molecularly Imprinted Electrochemical Sensor Based on Reduced Graphene Oxide-Gold Nanoparticles-Poly(p-aminobenzoic Acid) Nanocomposites for the Determination of Sunset Yellow
Authors: Peng Youyuan , Li Zhuojialu 
Published: November 2023

Background:
In this work, the reduced graphene oxide decorated with gold nanoparticles
(Au/rGO) had been synthesized on glass carbon electrode (GCE) using a simple one-step electrochemical
method. The molecularly imprinted poly(p-aminobenzoic acid) (PABA) film was prepared
for the analysis of sunset yellow (SY) on Au/rGO/GCE by electropolymerization of p-aminobenzoic
acid (pABA) and SY.

Methods:
Methods, such as scanning electron microscope (SEM), cyclic voltammetry (CV), and
electrochemical impedance spectroscopy (EIS) were used to characterize the successful formation of
imprinted films.

Results:
Under optimized experimental conditions, the Au/rGO/GCE based molecularly imprinted
sensor (MIP/Au/rGO/GCE) exhibited excellent performance for SY, and a linear range was obtained
from 0.002 μM to 8 μM with a detection limit of 0.5 nM. The responses of the imprinted sensor
maintained higher than 93% of the initial values after 15 days of storage.

Conclusion:
The MIP/Au/rGO/GCE has been used for the sensitive and selective detection of SY in
real food samples with acceptable recoveries, the combination of Au and rGO significantly improved
the sensitivity of the proposed sensor due to the synergistic effect of gold nanoparticles and rGO.
The resulting sensor also exhibited satisfactory reproducibility and stability, and the proposed platform
could be further expected for the detection of other food additives and various electroactive
species.
Design of Dendritic Foldamers as Catalysts for Organic Synthesis
Authors: Baby Sherlymole P. , George Smitha , Krishnapillai Sreekumar 
Published: November 2023

Background::
Multistranded foldamers mimic biopolymer architecture, through the assembly
and folding of intrinsically flexible polymeric chains attached to polyol core have been
synthesised here. The synthesised dendritic motifs possess helical cavities with properly arranged
active sites. As these cavities are large enough to accommodate guest molecules, their application
as synthetic foldamer catalyst were investigated in Knoevenagel and Mannich reactions.

Methods::
It is presumed to be the potentiality of dendritic foldamers to form reverse micelle in the
interior of helical motif containing many reactive sites.

Results::
Inside the dendritic foldamer, the substrates are adequately concentrated, work together in
cooperation for ligand-binding, and stabilize the transition state as in enzymes that helps to accelerate
the reaction rate many times greater than in bulk solution.

Conclusion::
An unrivalled reaction rate and high yield of products were obtained within a short
time in both Knoevenagel and Mannich reactions by using dendritic foldamers as catalysts.
Herbs as Hair Care Cosmetic Agents: Mini Review
Authors: Vakte Sanket R. , Mahajan Yash V. , Lohagaonkar Neeraj B. , Dolas Ramdas T. , Kulkarni Abhijeet D. , Gangurde Subodh A. , Jha Pravin K. , Byahatti Vivek V. , Gambhire Makarand S. 
Published: November 2023

Abstract:Healthy hair is an important part of a beautiful body. Thus, new developments in hair science and hair care have been reported in the literature, and innovations and ideas in hair care and cosmetics are required. Hair care products are used to keep the scalp clean and moisturize the hair. Hair care products also help control hair structure and behavior, keeping hair in a controlled environment if necessary. Natural cosmetics are safer to use when compared with other synthetic products. They are hypoallergenic, dermatologist-tested and proven to be safe to use anytime, anywhere. Hair cosmetics consist of different agents such as hair oil, hair tonic, anti-dandruff, hair dye, etc. This review focuses on different types of herbs that can be used cosmetically for hair care.
Analyzing User Reviews of the First Digital Contraceptive: Mixed Methods Study
Authors: Ciolfi Felice Marianela , Søndergaard Marie Louise Juul , Balaam Madeline 
Published: November 2023

Background
People in Western countries are increasingly rejecting hormone-based birth control and expressing a preference for hormone-free methods. Digital contraceptives have emerged as nonhormonal medical devices that make use of self-tracked data and algorithms to find a user’s fertile window. However, there is little knowledge about how people experience this seemingly new form of contraception, whose failure may result in unwanted pregnancies, high health risks, and life-changing consequences. As digital contraception becomes more widely adopted, examining its user experience is crucial to inform the design of technologies that not only are medically effective but also meet users’ preferences and needs.

Objective
We examined the user experience offered by Natural Cycles—the first digital contraceptive—through an analysis of app reviews written by its users worldwide.

Methods
We conducted a mixed methods analysis of 3265 publicly available reviews written in English by users of Natural Cycles on the Google Play Store. We combined computational and human techniques, namely, topic modeling and reflexive thematic analysis.

Results
For some users of digital contraception, the hormone-free aspect of the experience can be more salient than its digital aspect. Cultivating self-knowledge through the use of the technology can, in turn, feel empowering. Users also pointed to an algorithmic component that allows for increased accuracy over time as long as user diligence is applied. The interactivity of the digital contraceptive supports mutual learning and is experienced as agential and rewarding. Finally, a digital contraceptive can facilitate sharing the burden of contraceptive practices or highlight single-sided responsibilities while creating points of friction in the required daily routines.

Conclusions
Digital contraception is experienced by users as a tamed natural approach—a natural method contained and regulated by science and technology. This means that users can experience a method based on a digital product as “natural,” which positions digital contraceptives as a suitable option for people looking for evidence-based nonhormonal contraceptive methods. We point to interactivity as core to the user experience and highlight that a digital contraceptive might allow for collaboration between partners around contraceptive practices and responsibilities. We note that the user diligence required for the digital contraceptive to provide accurate and frequent data is sometimes not enough. Future research could look at designing (and redesigning) digital contraceptives with primary users and intimate partners, enhancing the experience of tamed naturalness; exploring how trust fluctuates among involved actors and in interactions with the technology; and, ultimately, designing more inclusive approaches to digital contraception.
Pediatric Delirium Educational Tool Development With Intensive Care Unit Clinicians and Caregivers in Canada: Focus Group Study
Authors: Wood Michael , Gandhi Kavi , Chapman Andrea , Skippen Peter , Krahn Gordon , Görges Matthias , Stewart S Evelyn 
Published: November 2023

Abstract

Background
Pediatric intensive care unit (PICU)–associated delirium contributes to a decline in postdischarge quality of life, with worse outcomes for individuals with delayed identification. As delirium screening rates remain low within PICUs, caregivers may be able to assist with early detection, for which they need more education, as awareness of pediatric delirium among caregivers remains limited.

Objective
This study aimed to develop an educational tool for caregivers to identify potential delirium symptoms during their child’s PICU stay, educate them on how to best support their child if they experience delirium, and guide them to relevant family resources.

Methods
Web-based focus groups were conducted at a tertiary pediatric hospital with expected end users of the tool (ie, PICU health care professionals and caregivers of children with an expected PICU length of stay of over 48 h) to identify potential educational information for inclusion in a family resource guide and to identify strategies for effective implementation. Data were analyzed thematically to generate requirements to inform prototype development. Participants then provided critical feedback on the initial prototype, which guided the final design.

Results
In all, 24 participants (18 health care professionals and 6 caregivers) attended 7 focus groups. Participants identified five informational sections for inclusion: (1) delirium definition, (2) key features of delirium (signs and symptoms), (3) postdischarge outcomes associated with delirium, (4) tips to inform family-centered care, and (5) education or supportive resources. Participants identified seven design requirements: information should (1) be presented in an order that resembles the structure of the clinical discussion around delirium; (2) increase accessibility, recall, and preparedness by providing multiple formats; (3) aim to reduce stress by implementing positive framing; (4) minimize cognitive load to ensure adequate information processing; (5) provide supplemental electronic resources via QR codes; (6) emphasize collaboration between caregivers and the health care team; and (7) use prompting questions to act as a call to action for caregivers.

Conclusions
Key design requirements derived from end-user feedback were established and guided the development of a novel pediatric delirium education tool. Implementing this tool into regular practice has the potential to reduce distress and assist in the early recognition and treatment of delirium in the PICU domain. Future evaluation of its clinical utility is necessary.
Mortalidad materna por trastornos hipertensivos en Chile durante 1999-2019
Authors: Duncan-Heinz Mikaela , García-García Amanda , Ruminot-Vidal Anita , Bonnefoy-Hermosilla Dennisse , Siefert-Espinosa Marla , Carrasco-Roa María-José , Kilchemmann-Fuentes Carlos 
Published: November 2023

Antecedentes: los trastornos hipertensivos son alteraciones fisiopatológicas frecuentes y graves. En Latinoamérica son responsables de casi el 26% de las muertes maternas, mientras que en Chile corresponden a la segunda causa de defunción materna, después de las enfermedades médicas concurrentes al embarazo. En efecto, a nivel nacional, se ha observado que las muertes maternas por esta patología han sido elevadas en comparación con las defunciones maternas por otras causas. El objetivo de esta investigación, por tanto, es analizar las razones de mortalidad materna por trastornos hipertensivos en Chile entre 1999 y 2019.

Métodos: se realizó un estudio transversal de tipo ecológico de serie temporal. Se analizó el número de madres fallecidas por trastornos hipertensivos en el período 1999-2019 en Chile, excluyéndose las madres fallecidas por otras causas. Los datos se recopilaron del Departamento de Estadísticas e Información de Salud (DEIS) del Ministerio de Salud. Se empleó estadística descriptiva y análisis bivariado mediante un modelo de regresión lineal simple. Para ello se utilizó el software STATA-16.

Resultados: de los datos analizados se obtuvo un total de 196 madres fallecidas por trastornos hipertensivos. La razón de mortalidad materna mayor fue de 5.8 en 2001, mientras que la menor razón de defunciones maternas se registró en 2003 y 2015, siendo de 1.6 en ambos años. Además, se observó una reducción significativa de 0.11 en promedio por año.

Conclusión: se observa una disminución en las razones de mortalidad materna por trastornos hipertensivos en Chile, en el período 1999-2019.
DMAIC como herramienta para implementar un sistema de mejora para incrementar la productividad en la industria del sombrero
Authors: García-González Ramón , Paredes-Castañeda José Antonio , Bayona-Ibáñez Eduar 
Published: November 2023

El presente estudio es una investigación aplicada que tiene como objetivo el diagnóstico de la industria maquiladora del sombrero en la región de Tehuacán, Puebla, México y con base a ello adaptar la filosofía de Manufactura esbelta como una estrategia para permanecer dentro del mercado globalizado apoyado en la herramienta DMAIC, para ello se elaboró un diagnostico en las empresas maquiladoras aplicando una serie de cuestionarios para determinar las causas que generan la baja productividad de este sector, posteriormente se cuantificó las variables que afectan a la productividad continuando con un análisis e integración de sistemas de mejora y control de los métodos para garantizar la permanencia de este tipo de empresas en un mercado globalizado, los resultados de los cuestionarios arrojaron una situación muy crítica que explica el nivel bajo de competitividad que prevale dentro de este tipo de empresas y con base a dichos resultados de diseño un sistema de mejora.