bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of recurrent hernia in peritoneal dialysis patients
Authors: Hao Long , Hong Xiaoming , Sha Hongcun , Zhao Yu 
Published: October 2023

Abstract
Peritoneal dialysis (PD) is the most commonly used treatment for patients with end-stage renal disease and has the advantages of simple operation and low treatment costs. However, long-term PD may lead to inguinal hernia formation, which needs to be repaired as early as possible. There are many studies on this kind of hernia, but there are few reports about how to treat recurrent hernia in PD patients. Therefore, we present a case of a female PD patient who suffered from a recurrent femoral hernia after primary hernioplasty. We successfully proceeded with treatment by laparoscopic transabdominal preperitoneal hernia repair. The patient was scheduled to receive temporary haemodialysis until the normal PD dose was restored. After 36 months of follow-up, we found that there was no recurrence of hernia, and the function of the PD catheter was normal.
Corpus philology: Using the Dictionary of Old English to get bigger data for Old English spelling variation
Authors: Faulkner Mark 
Published: October 2023

Abstract
This article presents a methodology for obtaining large datasets for the spelling of individual phonological segments in Old English texts, based on searching the Dictionary of Old English Corpus for the attested spellings listed in the Dictionary of Old English A-H. It exemplifies this ‘corpus philology’ through a study of 216,526 spellings for words beginning with h followed by a vowel, using a variety of techniques to evaluate the methodology’s precision and recall, which are calculated as very high for &lt;h-&gt;initial spellings (precision 100% precision, recall 92.1%) and moderate, but still usable, for &lt;h-&gt;less spellings (precision 85.5%, recall 58.3%). Data for fourteen other segments related to the behaviour of h- in Old English is presented in the Supplementary Materials that complement the paper online. This dataset of 379,484 spellings from 2,605 Old English texts is shown to seriously problematize the findings of traditional philology, the conclusions of which are in contrast based on only a handful of spellings from a few texts, and to have the potential to radically enhance our understanding of the literary and linguistic histories of English.
Transmission problems? An embedded approach for unification of Latin prefixes and text variants during text matching
Authors: Schropp Franziska , Konrad Thomas E , Revellio Marie , Feichtinger Barbara 
Published: October 2023

Abstract
The manuscript tradition of pre-modern texts poses a specific problem for scholars in the field of Digital Humanities: before printing made the production of standardized editions of texts feasible, copying texts by hand (and often by different people) was inherently an error-prone process, which not only led to differences in wording but also in spelling—across multiple transmitted variants. This applies especially to ancient texts, where the temporal distances to the archetypes tend to be fairly large. In computerized research, especially in the case of text matching within the field of citation research and text mining, these differences in wording and spelling—however small they might be—may prevent a successful matching of texts. This case study presents a solution for the problem of textual differences arising from (non-)assimilated prefixes in Latin, a feature where modern editions mostly differ from author to author, but sometimes even between two editions of the same text. With regard to the letters of the church father Jerome as well as Virgil’s Eclogues, Georgics, and Aeneid, two approaches are compared in terms of error rate and efficiency for a given set of prefixes: (1) performing and (2) reversing corpus-wide assimilation. Moreover, the broader implications of the (in-)accessibility of text-critical data in digital editions are discussed. Finally, general desiderata regarding text-critical data for computerized research on classical texts are elaborated.
Detection of the significant impact of source clustering on higher order statistics with DES Year 3 weak gravitational lensing data
Authors: Gatti M , Jeffrey N , Whiteway L , Ajani V , Kacprzak T , Zürcher D , Chang C , Jain B , Blazek J , Krause E , Alarcon A , Amon A , Bechtol K , Becker M , Bernstein G , Campos A , Chen R , Choi A , Davis C , Derose J , Diehl H T , Dodelson S , Doux C , Eckert K , Elvin-Poole J , Everett S , Ferte A , Gruen D , Gruendl R , Harrison I , Hartley W G , Herner K , Huff E M , Jarvis M , Kuropatkin N , Leget P F , MacCrann N , McCullough J , Myles J , Navarro-Alsina A , Pandey S , Prat J , Raveri M , Rollins R P , Roodman A , Sanchez C , Secco L F , Sevilla-Noarbe I , Sheldon E , Shin T , Troxel M , Tutusaus I , Varga T N , Yanny B , Yin B , Zhang Y , Zuntz J , Allam S S , Alves O , Aguena M , Bacon D , Bertin E , Brooks D , Burke D L , Rosell A Carnero , Carretero J , Cawthon R , da Costa L N , Davis T M , De Vicente J , Desai S , Doel P , García-Bellido J , Giannini G , Gutierrez G , Ferrero I , Frieman J , Hinton S R , Hollowood D L , Honscheid K , James D J , Kuehn K , Lahav O , Marshall J L , Mena-Fernández J , Miquel R , Ogando R L C , Palmese A , Pereira M E S , Malagón A A Plazas , Rodriguez-Monroy M , Samuroff S , Sanchez E , Schubnell M , Smith M , Sobreira F , Suchyta E , Swanson M E C , Tarle G , Weaverdyck N , Wiseman P ,   DES Collaboration
Published: October 2023

ABSTRACT
We measure the impact of source galaxy clustering on higher order summary statistics of weak gravitational lensing data. By comparing simulated data with galaxies that either trace or do not trace the underlying density field, we show that this effect can exceed measurement uncertainties for common higher order statistics for certain analysis choices. We evaluate the impact on different weak lensing observables, finding that third moments and wavelet phase harmonics are more affected than peak count statistics. Using Dark Energy Survey (DES) Year 3 (Y3) data, we construct null tests for the source-clustering-free case, finding a p-value of p = 4 × 10−3 (2.6σ) using third-order map moments and p = 3 × 10−11 (6.5σ) using wavelet phase harmonics. The impact of source clustering on cosmological inference can be either included in the model or minimized through ad hoc procedures (e.g. scale cuts). We verify that the procedures adopted in existing DES Y3 cosmological analyses were sufficient to render this effect negligible. Failing to account for source clustering can significantly impact cosmological inference from higher order gravitational lensing statistics, e.g. higher order N-point functions, wavelet-moment observables, and deep learning or field-level summary statistics of weak lensing maps.
Immune signatures of checkpoint inhibitor-induced autoimmunity—A focus on neurotoxicity
Authors: Müller-Jensen Leonie , Schulz Axel R , Mei Henrik E , Mohr Raphael , Ulrich Claas , Knape Philipp , Frost Nikolaj , Frischbutter Stefan , Kunkel Desiree , Schinke Christian , Ginesta Roque Lorena , Maierhof Smilla K , Nickel Florian T , Heinzerling Lucie , Endres Matthias , Boehmerle Wolfgang , Huehnchen Petra , Knauss Samuel 
Published: October 2023

Abstract

Background
Neurologic immune-related adverse events (irAE-n) are rare but severe toxicities of immune checkpoint inhibitor (ICI) treatment. To overcome diagnostic and therapeutic challenges, a better mechanistic understanding of irAE-n is paramount.

Methods
In this observational cohort study, we collected serum and peripheral blood samples from 34 consecutive cancer patients with irAE-n (during acute illness) and 49 cancer control patients without irAE-n (pre- and on-ICI treatment, n = 44 without high-grade irAEs, n = 5 with high-grade nonneurologic irAEs). Patients received either anti-programmed cell death protein (PD)-1 or anti-PD ligand-1 monotherapy or anti-PD-1/anti-cytotoxic T-lymphocyte-associated protein-4 combination therapy. Most common cancers were melanoma, lung cancer, and hepatocellular carcinoma. Peripheral blood immune profiling was performed using 48-marker single-cell mass cytometry and a multiplex cytokine assay.

Results
During acute illness, patients with irAE-n presented higher frequencies of cluster of differentiation (CD)8+ effector memory type (EM-)1 and central memory (CM) T cells compared to controls without irAEs. Multiorgan immunotoxicities (neurologic + nonneurologic) were associated with higher CD8+ EM1 T cell counts. While there were no B cell changes in the overall cohort, we detected a marked decrease of IgD− CD11c+ CD21low and IgD− CD24+ CD21high B cells in a subgroup of patients with autoantibody-positive irAE-n. We further identified signatures indicative of enhanced chemotaxis and inflammation in irAE-n patients and discovered C-X-C motif chemokine ligand (CXCL)10 as a promising marker to diagnose high-grade immunotoxicities such as irAE-n.

Conclusions
We demonstrate profound and partly subgroup-specific immune cell dysregulation in irAE-n patients, which may guide future biomarker development and targeted treatment approaches.
ChatGPT in research and health professions education: challenges, opportunities, and future directions
Authors: Sahu Pradeep Kumar , Benjamin Lisa A , Singh Aswal Gunjan , Williams-Persad Arlene 
Published: October 2023

Abstract
ChatGPT was launched by OpenAI in November 2022 and within 2 months it became popular across a wide range of industrial, social, and intellectual contexts including healthcare education. This article reviews the impact of ChatGPT on research and health professions education by identifying the challenges and opportunities in these fields. Additionally, it aims to provide future directions to mitigate the challenges and maximize the benefits of this technology in health professions education. ChatGPT has the potential to revolutionize the field of research and health professions education. However, there is a need to address ethical concerns and limitations such as lack of real-time data, data inaccuracies, biases, plagiarism, and copyright infringement before its implementation. Future research can highlight the ways to mitigate these challenges; establish guidelines and policies; and explore how effectively ChatGPT and other AI tools can be used in the field of research and healthcare professions education.
EURADOS ISO/IEC 17025 guidance for IMS: suggestions on how to interpret and implement the requirements including examples from accredited laboratories
Authors: Petrovic B , Martin R , Romero A M , Askounis P , Buchanan L , Rossi F , Bernat R , Alves J G 
Published: October 2023

Abstract
Individual monitoring of external radiation is an activity usually regulated by national regulatory bodies in most countries. Regulations generally contain technical requirements to be met by the individual monitoring services (IMS), in order to ensure that the measurements are correct and therefore the dosimetry results are reliable. In some countries, the requirements include or even consist of the accreditation of the service according to the standard ISO/IEC 17025: ‘General requirements for the competence of testing and calibration laboratories.’ It is a fact that accreditation is a growing trend among European IMS as a way to guarantee confidence in their technical competence. The acceptance of the dosimetry results between countries and their indentation in the respective National Dose Registries is facilitated if laboratories conform to the ISO/IEC 17025 standard. In the framework of the activities of EURADOS (European Radiation Dosimetry Group) working group 2 ‘Harmonization of Individual Monitoring in Europe’ and attending to the concern of many European IMS in the process of accreditation, a guide has been prepared. The purpose was to assist and encourage IMS to apply for accreditation and to share the authors’ own experience with the process. The guide intends to be a practical reference for IMS on how to interpret and implement the ISO/IEC 17025 requirements to the specific activity of a personal dosimetry service for external radiation, emphasizing those aspects of special interest. It includes examples from dosimetry laboratories already accredited. The major novelties from a new edition of ISO/IEC 17025: 2017 are also identified in the guide. Finally, the guide aims to assist the auditing process, giving examples of auditor’s questions and how to show evidence of compliance. The main findings are presented.
The European Radiation Dosimetry Group—a 40 year success story
Authors: Rühm Werner , Pihet Pascal , Schuhmacher Helmut 
Published: October 2023

Abstract
The European Radiation Dosimetry Group (EURADOS) was founded in 1982. Since then, the group has continuously developed and is currently a network of 80 institutions and more than 600 individual scientists across Europe, including exchange with the scientific community outside of Europe. EURADOS supports research and development of dosimetry and harmonising dosimetric practices. This paper describes the major milestones in the history of the organization. It starts from the very beginning when the idea was born and describes periods during which the role and strategy of the network had to be defined, elaborated and refined. Finally, it ends to date where EURADOS appears as an independent self-sustainable association, which is a reliable partner for various international organisations in radiation research and radiation protection. Major activities of EURADOS are highlighted such as (1) establishment and coordination of Working Groups, (2) regular organization of dosimetric intercomparisons for quality assurance of dosimetry procedures, (3) development and organization of education and training events, and (4) contributions towards the development of strategic and integrated radiation research in Europe.
Calibration of the W-PIE neutron spectrometer at CERF reference facility
Authors: Cirillo Andrea , Caresana Marco 
Published: October 2023

Abstract
The W-PIE is a cosmic neutron spectrometer used for environmental measurements, developed by Politecnico di Milano. The instrument is based on the Artkis M800 thermal neutron detector and works as a 4-channel spectrometer for detecting neutrons in the energy range of 0.01 eV–1 GeV. After the spectrometer had been calibrated in some monoenergetic neutron fields at the PIAF facility of PTB, the instrument was tested in the neutron field generated at the CERF facility, whose spectrum fairly resembles the cosmic one. This measurement is a precious tool for predicting the performance of the instrument in a realistic situation.
Development of A 14.8-MEV Mono-Energetic Neutron Field in Korea Research Institute of Standards and Science
Authors: Yoon Young Soo , Kim Jungho , Park Hyeoungwoo , Park Hyeonseo 
Published: October 2023

Abstract
A standard irradiation field for 14.8-MeV neutrons is under development for mono-energetic neutron standards research in the Korea Research Institute of Standards and Science, Republic of Korea. We developed a target chamber with the associated alpha particle (AAP) system for 14.8-MeV mono-energetic neutrons by a T(d,n)4He reaction. We designed the target chamber and the AAP detector system using a two-body kinematic calculation. We conducted simulations of the T(d,n)4He reaction on a tritiated target to determine a specification of the target and the AAP detector. This paper will discuss the simulation and calculation results for the associated particle system design.
Experiences in transitioning a testing laboratoryto the new ISO/IEC 17025:2017 standard
Authors: Hajek Michael , Bavio Marta A , Benesch Tobias N , Suárez Rodolfo Cruz , Hamel Nadia , Pinak Miroslav , Tucker David M , Wilding Allison 
Published: October 2023

Abstract
Since its inception, the international quality standard ISO/IEC 17025 has been revised twice. The most recent edition adopted a new structure to align with other conformity assessment and quality management standards, harmonized the terminology with the International Vocabulary of Metrology and introduced the concept of risk-based thinking. This paper disseminates the experience of the IAEA Radiation Safety Technical Services Laboratory in successful transition and re-accreditation to ISO/IEC 17025:2017. It covers all stages of the transition cycle: from conducting a gap analysis between the existing quality system and the requirements in the revised standard, updating the corresponding quality documents, developing training and communication plans for laboratory personnel, to monitoring the changes and improving the system through auditing, management review and participation in proficiency testing schemes. Lessons learned about building operational resilience and maintaining a business continuity management system to prepare for, respond to, and recover from disruptions are considered.
Assessment of the impact on a PADC neutron dosimetry system of the new operational dose quantities proposed in ICRU report 95
Authors: Moreno Brahim , Million Marc , Thomas David , Taylor Graeme 
Published: October 2023

Abstract
The International Commission on Radiation Units and Measurements, ICRU, have recommended, in ICRU Report 95, the adoption of new operational quantities for use in radiation protection monitoring. Their implementation will pose problems for instrument manufacturers supplying area dosemeters and for individual monitoring services providing personal dosemeters for radiation workers. The problems arise for photon, neutron and beta dosimetry, but this paper deals solely with neutron personal dosemeters based on poly-allyl diglycol carbonate (PADC) plastic. It presents information on the problems to be expected based on data from calibrations of actual personal neutron dosemeters in terms of the existing dose quantities.
Application of LiMgPO4 crystal for proton beam quality control in radiotherapy
Authors: Wróbel Damian , Kowalski Tomasz , Kusyk Sebastian , Marczewska Barbara , Nowak Tomasz , Olko Paweł , Swakoń Jan 
Published: October 2023

Abstract
The radioluminescence (RL) emitted by LiMgPO4 detector under proton beam irradiation was investigated in real time at the radiotherapy facility in the Institute of Nuclear Physics Polish Academy of Sciences in Krakow. The facility uses protons accelerated by the AIC-144 isochronous cyclotron up to the energy of 60 MeV. The measurements of RL were carried out using a remote optical fiber device with a luminophore detector and photomultiplier located at opposite ends of the optical fiber. A thin slice of LiMgPO4 doped with Tm (1.2 mol%) crystal was exposed to the proton beam. The tested detector allowed for the measurement of proton beam current, flux fluence and determination of proton beam time structure parameters. The investigation of LiMgPO4 crystal showed its high sensitivity, fast reaction time to irradiation and possibility of application as the detector for control of proton beam parameters.
Measurements in pulsed neutron fields
Authors: Caresana Marco , Cirillo Andrea , Bolzonella Matteo 
Published: October 2023

AbstractDosimetry in pulsed and mixed radiation fields represents an important challenge in radiation measurements, because in several accelerator technologies, the acceleration occurs in bunches of particles with short time duration, producing intense radiation pulses spaced by a relatively long time of beam off. The stray mixed radiation field generated around these installations maintains the same time structure as the primary beam and causes a problem in workplace fields’ monitoring. Active neutron detectors normally used in steady neutron fields, specifically REM-counters and Bonner sphere spectrometers, can suffer pulsed fields because of the high dead time losses during the bursts and are often inadequate for pulsed field monitoring. This work reviews the efforts of European Radiation Dosimetry Group (EURADOS), and in particular of the Working Group 11 ‘High Energy Radiation Fields’, to define the problem, characterize instrumentation and to propose solutions to the issue of pulsed and mixed radiation fields. Despite the EURADOS initiative, several open issues still remain. A metrological traceability for pulsed neutron fields is missing. There is still room for the optimization and better characterization of available instruments. Initiatives of education and training are required.
Personal dosimetry at the Paul Scherrer Institute
Authors: Mayer Sabine , Bossin Lily , Christensen Jeppe B , Pedrazzi Lisa , Yukihara Eduardo G 
Published: October 2023

Abstract
The Paul Scherrer Institute (PSI) is the largest research institute for natural and engineering sciences in Switzerland. PSI develops, builds and operates complex large research facilities. Every year, &gt;2400 scientists from Switzerland and around the world come to PSI to use the facilities and to carry out experiments. Many areas at PSI are radiation protection areas. Depending on the radiation protection area, the work carried out and the time the users spend in these areas, they have to carry a personal dosemeter. PSI runs an individual monitoring service in compliance with the Swiss legislation on radiological protection and approved by the Swiss Federal Nuclear Safety Inspectorate. The service provides about 35 000 dosemeters per year for the internal and external customers consisting of whole-body dosemeters for photons and neutrons as well as extremity dosemeters. This paper gives an overview on the employed personal dosimetry techniques by the individual monitoring service of PSI, the number of distributed dosemeters for internal and external customers and statistics about the measured doses at PSI over 30 years.
Microdosimetry of a 62-MeV clinical proton beam with five detectors
Authors: Bianchi A , Agosteo S , Bortot D , Cirrone G A P , Colautti P , La Tessa C , Mazzucconi D , Missiaggia M , Petringa G , Rosenfeld A B , Selva A , Tran L , Verona C , Verona Rinati G , Conte V 
Published: October 2023

Abstract
In proton therapy, most treatment planning systems (TPS) use a fixed relative biological effectiveness (RBE) of 1.1 all along the depth-dose profile. Innovative TPS are now investigated considering the variability of RBE with radiation quality. New TPS need an experimental verification in the quality assurance (QA) routine in clinics, but RBE data are usually obtained with radiobiological measurements that are time consuming and not suitable for daily QA. Microdosimetry is a useful tool based on physical measurements which can monitor the radiation quality. Several microdosimeters are available in different research institutions, which could potentially be used for the QA in TPS. In this study, the response functions of five detectors in the same 62-MeV proton Spread Out Bragg Peak is compared in terms of spectral distributions and their average values and microdosimetric RBE. Their different response function has been commented and must be considered in the clinical practice.
Microdosimetric analysis of the radiation quality of two different proton beams in the distal edge of the depth-dose profile
Authors: Bianchi A , Selva A , Rossignoli M , Pasquato F , Missiaggia M , La Tessa C , Scifoni E , Tommasino F , Conte V 
Published: October 2023

Abstract
Proton-therapy exploits the advantageous depth-dose profile of protons to induce the highest damage to tumoral cells in the last millimetres of their range in sharp Bragg Peak. To cover the whole tumoral volume, beams of different energies are combined to create the Spread Out Bragg Peak (SOBP). In passive modulated beams, the energy spread is created with modulators in which the highest energy beam is degraded through different thicknesses of calibrated plastic materials. The highest energy is chosen depending on the deepest point that needs to be treated. This study aims to investigate differences in the radiation quality in the distal edge of SOBP beams with different initial energy and modulation techniques based on microdosimetric measurements with mini Tissue-Equivalent Proportional Counters. The beams investigated are the 62 MeV proton SOBP of the clinical facility of CATANA and the 148 MeV proton SOBP of the research beam line of the proton-therapy centre of Trento.