bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental Health and Societal Wealth Predict Movement Patterns of an Urban Carnivore
Authors: Wilkinson Christine E. , Quinn Niamh , Eng Curtis , Schell Christopher J. 
Published: February 2025

ABSTRACTHow societal, ecological and infrastructural attributes interact to influence wildlife movement is uncertain. We explored whether neighbourhood socioeconomic status and environmental quality were associated with coyote (Canis latrans) movement patterns in Los Angeles, California and assessed the performance of integrated social–ecological movement models. We found that coyotes living in more anthropogenically burdened regions (i.e. higher pollution, denser development, etc.) had larger home ranges and showed greater daily displacement and mean step length than coyotes in less burdened regions. Coyotes experiencing differing levels of anthropogenic burdens demonstrated divergent selection for vegetation, pollution, road densities and other habitat conditions. Further, movement models that included societal covariates performed better than models that only assessed ecological features and linear infrastructure. This study provides a unique social–ecological lens examining the anthropogenic drivers of urban wildlife movement, which should be applicable to urban planners and conservationists when building more equitable, healthy and wildlife‐friendly cities.
Residence Time Structures Microbial Communities Through Niche Partitioning
Authors: Mueller Emmi A. , Lennon Jay T. 
Published: February 2025

ABSTRACTMuch of life on Earth is at the mercy of currents and flow. Residence time (τ) estimates how long organisms and resources remain in a system based on the ratio of volume (V) to flow rate (Q). Short τ should promote immigration but limit species establishment, while long τ should favour species that survive on limited resources. Theory suggests these opposing forces shape the abundance, diversity and function of flowing systems. We experimentally tested how residence time affects a lake microbial community by exposing chemostats to a τ gradient spanning seven orders of magnitude. Microbial abundance, richness and evenness increased non‐linearly with τ, while functions like productivity and resource consumption declined. Taxa formed distinct clusters of short‐ and long‐τ specialists consistent with niche partitioning. Our findings demonstrate that residence time drives biodiversity and community function in flowing habitats that are commonly found in environmental, engineered and host‐associated ecosystems.
Teenager Febrile Dystextia
Authors: Perrin de Brichambaut Florian , Dupuy Gabrielle , Sarda Eugénie , Boddaert Nathalie , Roux Charles‐Joris , Dabaj Ivana , Marret Stéphane , Aubart Mélodie , Desguerre Isabelle 
Published: February 2025

ABSTRACTIntroductionDystextia refers to a kind of aphasia. It is the inability or the difficulty to text with a mobile phone. It has been described 15 years ago in central neurologic pathologies like stroke, migraine with aura, neurologic tumor disease.Case presentationWe report the case of a 15‐year‐old boy who presented a febrile dystextia with acute insular lobes lesions in MRI. Human Simplex Virus 1 and lymphocytosis were present in the CSF and intravenous treatment with aciclovir has been initiated. Clinical signs were completely reversible.DiscussionThis case enhances the importance of emerging symptoms related to the common use of 21st century technology—such as smartphones—especially among younger patients. It also corroborates the association between the insular lobe and dystextia.ConclusionThis is the first report of herpetic meningoencephalitis revealed through febrile dystextia in a child.
Wound Healing Effect of HDACi Repositioned Molecules in the Therapy for Chronic Wounds Models
Authors: Santos‐Mena Alan , Gonzalez‐Muñiz Oscar , Rodríguez‐Carlos Adrian , Guerrero Alejandro Rivas , Mendieta Crisol Rodriguez , Jacobo Delgado Yolanda M. , Muñoz Gerardo Sauceda , Rosenstein Yvonne , Trujillo‐Paez Valentin , Portales‐Perez Diana , de Jesus Gonzalez Luis A. , Calvillo Renato , Gonzalez‐Curiel Irma , Vitales‐Noyola Marlen , Rivas‐Santiago Bruno 
Published: February 2025

ABSTRACTGlobally, chronic wounds impact the health of millions of people, negatively affecting quality of life and healthcare budgets. Some of the crucial steps and pathways in healing mechanisms are the hypoxic response and the expression of host defence peptides, which are decreased in diseases related to chronic wounds such as diabetes mellitus and cardiovascular diseases. It has been shown that histone deacetylase inhibitors can induce the expression of Host Defence Peptides (HDP) by inducing the stabilisation and activation of hypoxia‐inducible factor 1‐α (HIF‐1α), promoting wound healing pathways, although their high cost and side effects limit clinical research. With the help of bioinformatics tools, we found potential histone deacetylase inhibitor candidates in an FDA‐approved drugs database. The candidates, 1,3‐Diphenylurea (DiPU), 2'‐Aminoacetanilide (Ace), and Tert‐butyl (2‐aminophenyl) carbamate (N‐boc), show wound healing effects in HaCaT cells, increasing cell migration possibly via HIF‐1α, inducing the expression of LL‐37 and vascular endothelial growth factor (VEGF), while in a mouse ring angiogenesis model, Ace and N‐boc have angiogenic effects. In a model of basal primary keratinocytes from donors with diabetes mellitus (DM), without DM, and from Diabetic Foot Ulcers (DFU), it was observed that only DiPU is capable of inducing LL‐37 in all scenarios. There is limited information about histone deacetylase inhibitors and wound healing but in this paper, we observe promising results and a proposed mechanism that involved specifically Histone Deacetylase 1 inhibition (HDAC1).
Untangling the Complexity of Climate Change Effects on Plant Reproductive Traits and Pollinators: A Systematic Global Synthesis
Authors: Martén‐Rodríguez Silvana , Cristobal‐Pérez Edson Jacob , de Santiago‐Hernández Martín Hesajim , Huerta‐Ramos Guillermo , Clemente‐Martínez Lucero , Krupnick Gary , Taylor Orley , Lopezaraiza‐Mikel Martha , Balvino‐Olvera Francisco Javier , Sentíes‐Aguilar Eugenia M. , Díaz‐Infante Sergio , Aguirre Jaimes Armando , Novais Samuel , Cortés‐Flores Jorge , Lobo‐Segura Jorge , Fuchs Eric J. , Delgado‐Carrillo Oliverio , Ruiz‐Mercado Ilse , Sáyago‐Lorenzana Roberto , Pérez‐Arroyo Karen , Quesada Mauricio 
Published: February 2025

ABSTRACTClimate change is expected to affect the morphological, physiological, and life‐history traits of plants and animal pollinators due to more frequent extreme heat and other altered weather patterns. This systematic literature review evaluates the effects of climate change on plant and pollinator traits on a global scale to determine how species responses vary among Earth's ecosystems, climate variables, taxonomic groups, and organismal traits. We compiled studies conducted under natural or experimental conditions (excluding agricultural species) and analyzed species response patterns for each trait (advance vs. delay or no change for phenology, decrease vs. increase or no change for other traits). Climate change has advanced plant and animal phenologies across most Earth's biomes, but evidence for temporal plant–pollinator mismatches remains limited. Flower production and plant reproductive success showed diverse responses to warming and low water availability in Alpine and Temperate ecosystems, and a trend for increased or neutral responses in Arctic and Tropical biomes. Nectar rewards mainly experienced negative effects under warming and drought across Alpine and Temperate biomes, but scent emissions increased or changed in composition. Life form (woody vs. nonwoody species) did not significantly influence trait response patterns to climate change. Pollinator fecundity, size, life‐history, developmental, and physiological traits mostly declined with warming across biomes; however, animal abundance and resource acquisition traits showed diverse responses. This review identified critical knowledge gaps that limit our understanding of the impacts of climate change, particularly in tropical/subtropical biomes and southern latitudes. It also highlights the urgent need to sample across a greater range of plant families and pollinator taxa (e.g., beetles, wasps, vertebrates). The diversity of climate change effects should be assessed in the context of other anthropogenic drivers of global change that threaten critically important pollination interactions.
Mohs Micrographic Surgery Versus Wide Local Excision in the Treatment of Anogenital Squamous Cell Carcinoma: A Systematic Review
Authors: Yadlapati Sujitha , Rosa‐Nieves Priscilla M. , Lauck Kyle C. , Tolkachjov Stanislav N. 
Published: February 2025

ABSTRACTPrimary anogenital squamous cell carcinoma (SCC) is a locally aggressive malignancy that requires careful consideration of surgical margins. Anogenital SCC impacts the quality of life due to tissue removal, scarring, and sexual dysfunction. Mohs micrographic surgery (MMS) offers a compelling alternative to wide local excision (WLE) due to its complete margin control and potential tissue‐sparing properties. This analysis systematically reviews surgical modalities used for the management of anogenital SCC. Articles meeting eligibility criteria were identified using MEDLINE (via PubMed), Embase, Cochrane, and Scopus databases. All studies investigating surgical management of anogenital SCC with WLE (including vulvectomy) or MMS were considered. A total of 70 studies met inclusion criteria: 46 examined WLE patients, 8 utilized vulvectomy, and 24 examined MMS patients. MMS patients experienced lower local recurrence rates; regional and distant recurrence rates did not differ. The local, regional, and distant recurrence rates for WLE were 17.7%, 5.1%, and 6.0%, respectively, and 5.0%, 3.8%, and 4.3% for MMS. Local recurrence was more likely in patients treated with WLE (p < 0.0001). No differences were noted in regional recurrence (p = 0.444) and distant recurrence (p = 0.420). Study limitations include differences in tumor characteristics and follow‐up durations between the groups. The WLE group had larger tumors at presentation. Overall, MMS had superior outcomes for local recurrence compared to WLE and vulvectomy, making it a reasonable option for managing anogenital SCC.
Reasons for (Not) Seeking Care for Fatigue and Care Needs Among Patients With Inflammatory Bowel Disease: A Qualitative Interview Study
Authors: Bredero Quirine M. , Ter Avest Milou M. , Dijkstra Gerard , Fleer Joke , Schroevers Maya J. 
Published: February 2025

ABSTRACTAimsTo explore reasons why patients with inflammatory bowel disease (IBD) do (not) engage in fatigue‐related care and their care needs.DesignA qualitative interview study, using a phenomenological methodological approach.MethodsWe included 16 fatigued patients with IBD in remission. Data were collected between December 2021 and March 2022, using semi‐structured interviews. Template analysis was performed.ResultsWe identified six themes regarding reasons why (not) to seek care for fatigue: (1) Cognitions about fatigue and coping with fatigue, (2) perceptions of fatigue‐related care and previous care experiences, (3) perceived knowledge and behaviour of healthcare professionals, (4) physical and emotional well‐being, (5) social relationships and support, and (6) practical factors. Regarding their care needs, patients reported a need for a holistic and person‐centred care approach, with healthcare professionals actively addressing fatigue and offering care. They suggested a range of options for what care to offer, including eliminating physical causes of fatigue, discussing medication options, providing information on fatigue management, lifestyle support, psychological support, peer support and practical support.ConclusionBoth patient‐ and healthcare‐related factors play a role in why IBD patients do (not) seek fatigue‐related care. Our findings emphasise the importance of active screening and discussion of fatigue, using a holistic and person‐centred approach to treat fatigue.ImplicationsThis study contributes to the understanding of IBD patients' facilitators and barriers for seeking care for fatigue and their care needs. Moreover, results can inform nurses and physicians about ways to optimise the offer and uptake of fatigue‐related care, and the development of interventions that fit patients' needs. Results also provide implications for the treatment of fatigue in other chronic (inflammatory) conditions.ImpactThe current results can inform nurses and physicians about ways to optimise the offer and uptake of fatigue‐related care, and the development of interventions that fit the needs of patients with IBD. An increase in the uptake of effective and acceptable interventions can improve patients' health and well‐being.Reporting MethodFindings were reported following the consolidated criteria for reporting qualitative research (COREQ).Patient or Public ContributionNo patients, service users or members of the public were involved in this study. The study focused on patients' experiences with fatigue‐related care and their needs.
Reducing Climate Change Denial and Increasing Support for Climate‐Friendly Policies: The Role of Climate Change Education
Authors: Levy Sheri R. , Monahan Caitlin , Araiza Ashley , Ramırez Luisa , Palacios‐Espinosa Ximena 
Published: February 2025

ABSTRACTInsufficient US public education and misinformation from other sources contribute to climate change (CC) denial. Public US university students in the South (Study 1) and Northeast (Studies 1 and 2) were randomly assigned to watch two educational science videos on CC (experimental condition) or flu viruses (control condition). Experimental (vs. control) condition participants reported (a) less agreement with statements reflecting CC denial (immediate post‐test [Studies 1 and 2] and delayed post‐test [Study 2]); (b) greater agreement with statements about the existence, seriousness, and human causes of CC and hope for CC interventions (immediate post‐test [Studies 1 and 2]); (c) greater intentions to support climate‐friendly US policies (immediate post‐test [Study 1]); and (d) less negative feelings about CC (delayed post‐test [Study 2]), when controlling for gender and political leaning. Implications for effectively addressing CC education among university students with relatively easy‐to‐implement, time‐efficient, and cost‐effective interventions are discussed.
Situating Experience in Social Meaning: Stance, Salience, and Enregisterment
Authors: Hadodo Matthew John 
Published: February 2025

ABSTRACTThis article uses mixed methods to establish how social meanings are situated in lived experiences. I test whether Greek listeners recognize features of Istanbul Greek (IG) and whether they associate the same social meanings with the variety as IG speakers. Results from a verbal guise experiment and metapragmatic stancetaking discourse suggest the confluence of IG features co‐present in multiple Greek varieties (a) hinders non‐IG‐listeners from placing speakers and (b) allows for other varieties’ social meanings to influence judgments. Although listeners attend to multiple structures, features involved with allophonic processes are most salient. Consequently, the salience of competing processes led listeners to (re)interpret features based on their awareness of them in other enregistered speech. These findings add nuance to how enregisterment occurs within (sub)communities, and how social meanings are unevenly distributed among individuals based on the exemplars that emerge via enregisterment. Results further complicate how personae circulate and contribute to social differentiation.
Effect of using virtual reality on fatigue and mental workload as key determinants of perceived stress in neonatal intensive care staff: A randomized controlled trial feasibility study and protocol
Authors: Desai Saumil , Athalye‐Jape Gayatri , Bottcher Sarah , Campbell Catherine , Chiffings Debbie , Nathan Elizabeth , Fardinpour Ali , Kinnaird Lindsay , Bulsara Max , Rao Shripada 
Published: February 2025

AbstractBackgroundHealth care professionals (HCPs) in neonatal intensive care units (NICUs) are prone to significant stress, leading to deleterious mental health effects. Recently, some studies have explored virtual reality (VR) immersion experience to mitigate these risks. However, these studies vary in clinical settings, design and mental health parameters.AimTo report on the safety and feasibility of VR immersion experience in busy tertiary NICU HCPs.Study DesignTen eligible NICU HCPs without photosensitive epilepsy or cardiopulmonary disease participated. Participants underwent VR immersion (intervention arm; maximum of 15 min/session and 1 session/shift) during breaktimes in three consecutive shifts. They underwent a washout period, after which they completed 3 sessions as routine breaks (control arm) without VR experience. They completed pre–post break stress and survey questionnaires in both arms.ResultsAnalyses comprised data from 28 VR immersion and 27 control arm sessions (nine participants completed three sessions in both arms and one participant completed one session in intervention arm only). All VR immersion sessions were ‘really liked’ (60.7%) or ‘liked’ (39.3%). As far as the usage of VR devices were concerned, majority were deemed to be ‘really easy’ (25%) or ‘easy’ (57.14%). Quality of VR environments were reported to be ‘Excellent’ (28.6%) or ‘good’ (60.71%) in majority of sessions. Experience of chosen VR environments were ‘really liked’ (46.42%) or ‘liked’ (50%). Most importantly, the impact of VR experience on enhancing the break was deemed to be ‘Yes, a lot’ (46.42%) or ‘Yes, a bit’ (39.28%) in most sessions. Participants reported ‘very minor’ side effects in three VR sessions, none requiring any therapeutic interventions. Rest of the sessions reported ‘no’ side effects.ConclusionsVR immersion experience is safe and feasible in busy HCPs in a tertiary NICU. Future recommendations would be to compare VR immersion experience with other well‐being measures of staff.Relevance to Clinical PracticeVirtual reality immersion experience could be utilized for stress reduction in NICU HCPs.
A descriptive investigation of alarm activation in a critical care setting
Authors: Nguyen Van , MacDonald Brendan , Cignarella Anthony , Miller Charne 
Published: February 2025

AbstractBackgroundAlarm fatigue, a phenomenon referring to clinicians being desensitized to the high volume of monitoring alarms, can impact the working environment, clinical care and patient outcomes. Explorations and understandings of alarm fatigue have yet to be a focus of attention in the Australian context.AimTo describe the prevalence and type of alarms activated in intensive care and cardiac units in a major metropolitan hospital in Victoria, Australia.Study DesignThis study was a descriptive observation study of patient monitoring data gathered over a 1‐month time frame during April 2019. Data from the Philips Healthcare IntelliVue® Patient Monitoring system were extracted. After classifying the alarms into types (clinical or technical) and levels of urgency (lower or higher priority), further descriptive analysis was conducted to quantify the most prevalent alarms.ResultsDuring the study period, a total of 271 414 activated alarms were identified. The majority were clinical alarms (89.1%) compared with technical alarms (10.9%). Clinical alarms tended to be classified as high priority (55.1%); the most common were heart rate (36.7%) and premature ventricular contraction (18.8%). Technical alarms were predominantly electrocardiogram lead disconnection (89%). The frequency of alarms per patient‐bed day was highest in the acute cardiac unit (98 alarms) compared with the intensive care unit (67 alarms).ConclusionStaff education and a culture of individual alarm customization might influence the number of alarms activated in the study settings. Further research is also required to examine alarm fatigue in other Australian critical care settings, and responses to alarms by clinicians, and whether these responses are calibrated to detect clinical deterioration and sentinel events.Relevance to Clinical PracticeA bundle of interventions should be in place to increase the accuracy of alarm monitoring and to reduce non‐actionable alarms in order to reduce the possible impacts on clinicians, patients and their families/visitors.
Host diversity mediates the influence of landscape structure on parasite communities in Cerrado agricultural landscapes
Authors: Teles Wanderson Siqueira , Regolin André Luis , de Andrade‐Silva Beatriz Elise , Maldonado Junior Arnaldo , Vilela Roberto do Val , Borges‐Almeida Karen , Pereira Marcio Junior , Araujo Matheus Lima , Collevatti Rosane Garcia 
Published: February 2025

AbstractParasites are key elements in ecosystem functioning owing to their role in hosts’ population dynamics and abundance, regulation stabilizing trophic networks, and shaping community structure. Landscape changes can affect parasite communities because of changes in suitable microhabitats and on hosts’ community structure. In the Brazilian Cerrado, no study has so far analyzed the effects of intensive agricultural landscaping on helminth parasites of mammals. Here, we fill this knowledge gap, addressing the effects of landscape structure and the Sigmodontinae host's community structure on the richness and abundance of helminth parasites in agricultural landscapes. Using structural equation models, we found that the parasites’ richness and abundance are determined mainly by the rodent hosts’ community structure and are only indirectly affected by landscape structure. We found no direct effect of habitat fragmentation, habitat amount, and landscape compositional heterogeneity on the richness and abundance of helminth parasites, but they directly affected the hosts’ community. Moreover, we found no difference in both the host's and parasite's richness and abundance between crop growing and fallow seasons. Our results show that efforts to preserve helminth parasites may comprise landscape conservation strategies that preserve the biodiversity of the rodent hosts, including conservation and restoration of vegetation remnants at the landscape level.
Both Jasmonic Acid‐ and Abscisic Acid‐Mediated Signalling Pathways Regulate the Ovicidal Defence of Plants Against Phloem‐Feeding Insects
Authors: Gao Qing , Jin Nuo , Shen Zhifan , Guo Jingran , Lu Haiping , Han Shanjie , Xiao Wenhan , Lu Jing , Lou Yonggen 
Published: February 2025

ABSTRACTPlants perceive signals associated with herbivore eggs and in response initiate ovicidal defence. However, which phytohormone pathways regulate this defence and which defensive compounds dominate it remains largely unknown. Here, we found that the hatching rate of eggs of white‐backed planthopper (WBPH) Sogatella furcifera was significantly lower on a japonica rice variety P81 than an indica rice variety NB44. When infested by WBPH, P81 plants showed higher jasmonic acid (JA) and abscisic acid (ABA) responses than did NB44 plants; moreover, P81 plants produced the ovicidal compound benzyl benzoate and exhibited higher levels of some flavonoids, phenolamides, and volatiles than were found in NB44 plants. Impairing the ABA‐signalling pathway, especially the JA‐signalling pathway in P81 plants enhanced the survival of WBPH eggs. Decreasing levels of some flavonoids and phenolamides in P81 plants promoted WBPH egg survival. In vitro bioassays revealed that both naringenin and sakuranetin promote the ovicidal effect of benzyl benzoate on WBPH. The results demonstrate that JA‐ and ABA‐signalling pathways jointly regulate the rice ovicidal defence against WBPH, and that benzyl benzoate, as well as some other compounds, such as naringenin and sakuranetin, contribute to the mortality of WBPH eggs.