bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered Macrophages Tune Intratumoral Cytokines through Precisely Controlled Self‐Pyroptosis to Enhance Bladder Cancer Immunotherapy
Authors: Guo Pengyu , Dai Peng , Yang Shenghao , Wang Ziqi , Tong Zhichao , Hou Dayong , Liu Xiao , Xu Wanhai 
Published: November 2023

AbstractEngineered macrophages are a promising tool for drug delivery and immunotherapy in cancer treatment. However, simultaneous targeted enrichment and controllable immunological activation of these macrophages at the tumor site remains challenging. As a solution, macrophages loaded with an advanced nanoparticle encapsulating CpG‐conjugated magnetic nanoclusters (MNC) with indocyanine green (ICG) and nigericin (NIG) (MNC‐ICG‐NIG@SiO2 (MINS)), utilizing Se─Se bond‐modified SiO2, are designed and applied in bladder cancer, which is typically managed surgically, followed by Bacillus Calmette–Guerin (BCG) adjuvant instillation therapy. Upon intravenous administration, BCG‐mediated tumor‐localized inflammation leads to targeted accumulation of MINS@MΦ. MINS@MΦ accumulates within the tumor tissue and is immunologically activated through laser irradiation, leading to ICG‐mediated generation of reactive oxygen species, Se─Se bond cleavage, and subsequent NIG release to induce self‐pyroptosis. Consequently, MINS@MΦ releases Fe2+ ions and CpG, thus promoting the M1 polarization of tumor‐associated macrophages and secretion of appropriate antitumor cytokines. However, without intervention, MINS@MΦ undergoes apoptosis in the bloodstream after 48 h without eliciting any immune response. Therefore, this innovative approach optimizes and enhances the efficacy of BCG immunotherapy by precisely modulating the cytokines for effective bladder cancer treatment without inducing a systemic inflammatory response.
Exploring the context of use for voice user interfaces: Toward context‐dependent user experience quality testing
Authors: Klein Andreas M. , Deutschländer Jana , Kölln Kristina , Rauschenberger Maria , Escalona Maria José 
Published: November 2023

AbstractVoice user interface (VUI) systems, such as Alexa, Siri, and Google Assistant, are popular and widely available. Still, challenges such as privacy and the ability to have a dialog remain. In the latter example, the user expects a human‐like conversation, that is, that the VUI understands the dialog and its context. However, this VUI feature of context‐aware interaction is rather error prone. For this reason, we intend to explore the VUI context of use and its impact on interaction, that is, relevant user experience (UX). We see a demand for context‐dependent UX measurement because analyzing the context of use and UX assessment are both critical human‐centered design (HCD) methods. Therefore, we examine the VUI context of use by asking users about how, where, and for what they use VUIs, as well as their UX and improvement proposals. We interviewed people with disabilities who rely on VUIs and people without disabilities who use VUIs for convenience or fun. We identified VUI context‐of‐use categories and factors and explored their impacts on relevant UX qualities. Our result is a matrix containing these elements; thus, it provides an overview of the contextual UX of our target group's VUI interaction. We intend to develop a VUI context‐of‐use conceptual structure in the future based on this matrix, which is needed to create an automated context‐dependent UX measurement recommendation tool for VUIs. This conceptual structure could also be useful for automated UX testing in the context of VUI.
The effect of distance metrics in a general purpose synthesizer of imperative programs: A second empirical study using enlarged search spaces
Authors: Correia Alexandre R. S. , Iyoda Juliano M. , Mota Alexandre C. 
Published: November 2023

AbstractContextProgram synthesis is the task of automatically finding a program that satisfies the user intention. In previous work, we developed APS‐GA, a program synthesizer based on a genetic algorithm. As genetic algorithms depend on a fitness function, so does APS‐GA. Researchers argue that different distance metrics for a fitness function may reveal behavioral differences in the genetic algorithm. More recently, we presented initial evidence that APS‐GA was not affected by different distance metrics for its fitness function. However, that study was carried out on a medium‐sized scale.ObjectiveIn order to investigate our previous study on a larger scale, we extended our experiment to replicate it on a search space that is up to 6500 times larger than our previous work, and we ran it with a synthesis time that was at least 20 times longer. We have chosen the same five distance metrics as fitness functions to check whether they affect the synthesis task of five integer domain imperative toy programs.MethodA hypothesis test was proposed and experiments were conducted to observe the number of calls to the fitness function () and to measure the synthesis time ().ResultsBy considering a confidence level of 95% (with ), we found out that there were no significant differences in both and .ConclusionWith these results, our extended replication study suggests that the discrete distance metric constitutes the best choice for APS‐GA as it guides the search with the same effectiveness as the other metrics, and is cheaper to compute.
Flexural design curves of steel plate I‐girders at elevated temperatures: I‐girders with yield or local buckling failure mode
Authors: Rasoulnia Akbar , Broujerdian Vahid , Ghamari Ali , Ghadami Abbas 
Published: November 2023

SummaryThe present study was undertaken to characterize the structural behavior and ultimate flexural strength of steel plate I‐girders under pure flexural moment at elevated temperatures. A novel design procedure along with flexural design curves was proposed to predict the flexural behavior of the I‐girders and estimate corresponding ultimate flexural strengths. The main strategy of the procedure is to find an ambient‐temperature equivalent of the I‐girder by quantifying and formulating the effects of elevated temperatures. The proposed procedure comprises overall and partial phases. The former phase deals with the determination of equivalent laterally unbraced length, and the latter phase addresses the equivalent web and compression flange slenderness parameters. The calibration factor was defined to adapt the design curves to the effects of high compression flange slenderness parameters and residual stress at elevated temperatures. To generate comparative results, a numerical study was conducted by analyzing 216 finite element (FE) models. Fifty‐four out of 216 FE models with different cross‐sectional elements were dedicated to the I‐girders fail by yield or local buckling failure mode, the results of which are reported in the present paper. Data fitting analysis was carried out to capture the variation of calibration factor with respect to compression flange slenderness parameters. By calibrating the proposed design procedure, the results were converged and, therefore, good conformity was reached between the numerical and parametric results.
Addressing the needs and challenges of mentorship in veterinary medicine
Authors: Yanke Amy B. , Weigand Kelly A. , Hofmeister Erik H. 
Published: November 2023

AbstractVeterinary medicine provides a rewarding career but is met with a high degree of mental, emotional, and physical fatigue and, as a result, professional burnout. A structured mentoring system in veterinary schools is integral to promoting well‐being as well as professional and personal growth for resilience and lifelong learning. While professional programs (e.g., human medicine, nursing, dentistry, pharmacy) often provide mentorship opportunities, program descriptions, and evidence of effectiveness have limited review in the literature, especially for veterinary medicine. Depending on the individual's professional stage, mentor and mentee roles may be established throughout one's career between a faculty mentor and a veterinary student early in the curriculum, between near‐peer students, between a private practitioner and new graduate, between a faculty mentor and house officers (interns/residents), and others. Mentorship of junior faculty by senior faculty is also important to nurture successful retention, professional growth, and promotion. With all of these relationships, expectations should be developed between the mentor and mentee to achieve mutual benefit from the relationship.While instituting a mentoring program is beneficial, not all programs are created equal. To ensure a successful program, faculty must be trained to effectively mentor veterinary and graduate students. With adequate training, more seasoned students could also provide peer mentorship to less experienced students. Consideration should be given to how mentors and mentees are matched, recognizing that pairings based on core interests may strengthen foundational relationships. Effective mentoring relationships would ensure continued support for mentees as they develop in the years following graduation. With this article, we present the opportunities and challenges for mentoring within veterinary medicine, including a review of the literature.
Type I and type IV dermoid sinus with associated cervical spina bifida in a Labrador Retriever mixed breed dog
Authors: Torres Roman , Giovanella Carley , Sessums Kara 
Published: November 2023

AbstractA 6‐month‐old female Labrador Retriever mix rescued by a local shelter developed respiratory distress and later became tetraplegic. After transferring to a specialty centre, diagnostic imaging (CT and MRI) revealed spina bifida at C3 and dermoid sinuses at the level of C3 and T1. Surgery was performed to remove the dermoid sinuses. The dog was placed on broad‐spectrum antibiotics and a tapering anti‐inflammatory dose of prednisone, postoperatively. Independent ambulation was regained within 14 days with no recurrence of neurologic clinical signs.
Influence of scutellaria baicalensis extract on the thermo‐oxidative and composting stability of poly(butylene adipate‐co‐terephthalate)
Authors: Li Yueqiu , Kong Zhe , Zhang Jie , Wang Zhongwei , Cheng Guiqing , Yu Qing , Han Yuxi 
Published: November 2023

AbstractScutellaria baicalensis extract (SBE), as a natural phenolic antioxidant, was added to poly(butylene adipate‐co‐terephthalate) (PBAT) matrix. With the addition of SBE, both the short‐term and long‐term antioxidant activity of PBAT samples noticeably improved. The results showed that the oxidation onset temperature (OOT) value of the modified sample (PBAT‐SBE2.5 sample) is increased by 62°C versus neat PBAT. Compared with neat PBAT with decreased OOT value after 240 days of storage, the OOT values of modified samples showed no significant change after long‐term storage. The excellent antioxidant activity is attributed to the high total phenolic content in SBE, which provides significant free radical scavenging efficiency. Additionally, the introduction of SBE could effectively enhance the processing performance of the PBAT matrix, the melt flow rate of PBAT‐SBE2.5 increased by ca. 42.6%. Compared with neat PBAT, the addition of SBE has no obvious effect on the mechanical properties of the matrix, the tensile strength remains unchanged and the elongation at break of PBAT‐SBE2.5 retains 74%. Composting degradation experiment indicated that the SBE promoted the degradation of PBAT. Moreover, SBE could reduce the surface hydrophilic tendency of the film materials. All results reveal that SBE was a good natural multifunctional stabilizer for PBAT.Highlights
SBE shows high total phenolic content and free radical scavenging activity.
SBE improves the short‐term and long‐term antioxidant activity of PBAT.
The addition of SBE promoted the degradation of PBAT films.
SBE could effectively enhance the processing performance of the PBAT matrix.
Improvement and Analysis for Accuracy of Baseflow Using SWAT-CUP Premium in the Yongjeon Stream, South Korea
Authors: Kim Jong-Tae , Lee Chang-Hun , Lee Namjoo 
Published: November 2023

AbstractHere, the results of Soil and Water Assessment Tool (SWAT) simulation are calibrated and validated using SWAT-CUP Premium, and the R2 (coefficient of determination) values of simulated and observed flows are compared. According to the SWAT analysis of the Cheongsong Yongjeon stream basin, low accuracy of 0.40 was the R2 value for simulated and observed flows, and the baseflow was calculated at an annual average of 46.659 m3/s. During the same period, after calibration and validation using SWAT-CUP Premium, the R2 value of simulated and observed flows was improved to 0.71, and the evaluation indexes showed 0.51 for Nash–Sutcliffe efficiency (NS), 37.1 for percent bias (PBIAS), 0.73 for P-factor, and 0.33 for R-factor, indicating that the relationship between observed and simulated flows was improved. In addition, after calibration and validation, the baseflow was 56.951 m3/s, which was a more accurate value than the one before calibration and validation.
Single‐incision bone bridge lateral meniscus allograft transplantation: preserving neurovascular safety with promising results for posterior horn distortion and graft maturation
Authors: Lee JiHwan , Lee Dhong Won , Kyeong Tae Hyun , Lee Jung Wook , Kim Jin Goo 
Published: November 2023

AbstractPurposeThis study aimed to investigate the graft maturation and safety of single‐incision bone bridge lateral meniscus allograft transplantation (LMAT).MethodsThis study involved 35 patients who underwent LMAT between 2019 and 2020. All patients completed at least 2 years of follow‐up (median 34 months; range 24–43) and underwent preoperative magnetic resonance imaging (MRI) to assess the trajectory safety of the leading suture passer and all‐inside suture instrument (Fast‐Fix). Graft status was evaluated according to the Stoller classification.ResultsBased on preoperative MRI measurements, the expected trajectory of the leading suture passer did not transect the common peroneal nerve (CPN), with the closest distance between the expected trajectory and CPN being 1.4 mm and the average distance being 6.8 ± 3.2 mm. The average distance from the lateral meniscal posterior horn (LMPH) to the popliteal neurovascular bundle (PNVB) was 7.4 ± 2.6 mm and the nearest was 4.8 mm. The expected trajectory of the all‐inside suturing instrument did not transect the PNVB when the distance was at least 12 mm, from the most lateral margin of the posterior cruciate ligament (PCL). Grade 3 signal intensity in the posterior third of the allograft on MRI was observed in 6 of 35 (17.1%) patients. Amongst the grade 3 signal intensities in the posterior one‐third of the allografts, 3 of the 35 (8.5%) LMATs had a distorted contour.ConclusionThe single‐incision bone bridge LMAT technique introduced in this study is a convenient approach that preserves neurovascular safety and provides good results for the distortion of the posterior horn of the allograft and graft maturation. The safety zone for the penetrating devices during the procedure extended from 12 mm laterally to the most lateral margin of the PCL to the medial margin of the popliteal hiatus.Level of evidenceIV.
Spherical harmonic coefficients of isotropic polynomial functions with applications to gravity field modeling
Authors: Piretzidis Dimitrios , Kotsakis Christopher , Mertikas Stelios P. , Sideris Michael G. 
Published: November 2023

AbstractVarious aspects of gravity field modeling rely upon analytical mathematical functions for calculating spherical harmonic coefficients. Such functions allow quick and efficient evaluation of cumbersome convolution integrals defined on the sphere. In this work, we present a new analytical method for determining spherical harmonic coefficients of isotropic polynomial functions. This method in computationally flexible and efficient, since it makes use of recurrence relations. Also, its use is universal and could be extended to piecewise polynomials and polynomials with compact support. Our numerical investigation of the proposed method shows that certain recurrence relations lose accuracy as the order of implemented polynomials increases because of accumulation of numerical errors. Propagation of these errors could be mitigated by hybrid methods or using extended precision arithmetic. We demonstrate the relevance of our method in gravity field modeling and discuss two areas of application. The first one is the design of B-spline windows and filter kernels for the low-pass filtering of gravity field functionals (e.g., GRACE Follow-On monthly geopotential solutions). The second one is the calculation of spherical harmonic coefficients of isotropic polynomial covariance functions.
Inflammation as common link to progressive neurological diseases
Authors: Dias-Carvalho Ana , Sá Susana Isabel , Carvalho Félix , Fernandes Eduarda , Costa Vera Marisa 
Published: November 2023

AbstractLife expectancy has increased immensely over the past decades, bringing new challenges to the health systems as advanced age increases the predisposition for many diseases. One of those is the burden of neurologic disorders. While many hypotheses have been placed to explain aging mechanisms, it has been widely accepted that the increasing pro-inflammatory status with advanced age or “inflammaging” is a main determinant of biological aging. Furthermore, inflammaging is at the cornerstone of many age-related diseases and its involvement in neurologic disorders is an exciting hypothesis. Indeed, aging and neurologic disorders development in the elderly seem to share some basic pathways that fundamentally converge on inflammation. Peripheral inflammation significantly influences brain function and contributes to the development of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Understanding the role of inflammation in the pathogenesis of progressive neurological diseases is of crucial importance for developing effective treatments and interventions that can slow down or prevent disease progression, therefore, decreasing its social and economic burden.
Nitric Oxide (NO) and Hydrogen Sulfide (H2S): New Potential Biotechnological Tools for Postharvest Storage of Horticultural Crops
Authors: Corpas Francisco J. , Muñoz-Vargas María A. , González-Gordo Salvador , Rodríguez-Ruiz Marta , Palma José M. 
Published: November 2023

AbstractStorage and maintenance of horticultural products in optimal conditions for a reasonable period, once they have been harvested is a technological challenge. Diverse methods are generally used, i.e., low temperature but, in many cases, it may provoke undesirable collateral effects such as softening or promoting pathogens infections, thus causing their deterioration. Nitric oxide (·NO) and hydrogen sulfide (H2S) are compounds generated endogenously by plants with signaling properties that mediate fruit development and ripening. Additionally, when these molecules are applied exogenously, they can provide benefits such as maintaining the quality of horticultural products and even prolonging their shelf-life once they are stored. This review provides a broad perspective of ·NO and H2S metabolism in plant cells and, in addition, different plant models are described of how the exogenous application of either NO or H2S to horticultural products preserves nutritional quality during postharvest storage.
Graphical Abstract
Factors associated with in-hospital mortality in HIV-infected children treated for tuberculous meningitis hydrocephalus
Authors: Enicker Basil , Aldous Colleen 
Published: November 2023

Abstract
Purpose
The study aimed to investigate factors associated with in-hospital mortality in children diagnosed with tuberculous meningitis (TBM) hydrocephalus and HIV co-infection undergoing cerebrospinal fluid diversion procedures and their complications.

Methods
Data were collected retrospectively and prospectively between 2007 and 2022. Data collected included demographics, clinical characteristics, antiretroviral therapy (ART) status, biochemistry results, CD4 count, radiology findings, CSF diversion procedures (and complications), length of hospital stay (LOHS), and in-hospital mortality.

Results
Thirty-one children were included, with a mean age of 6.7 ± 5.3 years and 67.7% males. Median admission Glasgow Coma Scale (GCS) was 11 (IQR 9–15). Hypertonia (64.5%) and seizures (51.6%) were frequently observed clinical characteristics. Sixty-one percent of children were on ART. Cerebral infarcts and extra-meningeal TB were diagnosed in 64.5% and 19.3% of cases, respectively. The median CD4 count was 151 (IQR 70–732) cells/µL. Surgical procedures included ventriculoperitoneal shunt (VPS) in 26 cases and endoscopic third ventriculostomy (ETV) in five children. VPS complication rate was 27%. No complications were reported for ETV. Median LOHS was 7 days (IQR 4–21). Eleven children (35.5%) died during admission. Factors associated with mortality included GCS (p = 0.032), infarcts (p = 0.004), extra-meningeal TB (p = 0.003), VPS infection (p = 0.018), low CD4 count (p = 0.009), and hyponatremia (p = 0.002). No statistically significant factors were associated with VPS complications.

Conclusion
TBM hydrocephalus in HIV-infected children carries a high mortality. Clinicians in high-prevalence settings should have a high suspicion index and institute early treatment.
Acute pulmonary embolism and cancer: findings from the COPE study
Authors: Becattini Cecilia , Cimini Ludovica Anna , Bassanelli Giorgio , Maggioni Aldo P. , Pomero Fulvio , Lobascio Ilaria , Enea Iolanda , Pomata Daniela P. , Ruggieri Maria Pia , Zalunardo Beniamino , Novelli Anna , Di Fusco Stefania Angela , Triggiani Marco , Marzolo Marco , Fioravanti Chiara , Agnelli Giancarlo , Gonzini Lucio , Gulizia Michele M. ,   on behalf of COPE Investigators
Published: November 2023

Abstract
Background
Patients with acute venous thromboembolism associated with cancer have an increased risk of recurrences and bleeding in the long term.

Research question
To describe the clinical features and short-term course of patients with acute pulmonary embolism (PE) and active cancer, previous cancer or no cancer.

Study design and methods
Patients with acute PE included in COPE—prospective, multicentre study of adult patients with acute, symptomatic, objectively diagnosed PE—were classified as having active cancer, previous cancer, or no cancer.

Results
Overall, 832 patients had active cancer, 464 with previous cancer and 3660 patients had no cancer at the time of acute PE. The most prevalent primary sites of active cancer were urogenital (23.0%), gastrointestinal (21.0%), and lung (19.8%), with a high prevalence of metastatic disease (57.6%) and ongoing anticancer treatment (16.2%). At discharge, a direct oral anticoagulant was used in 43.1%, 78.8%, and 82.0% of patients with active cancer, previous cancer, and no cancer, respectively. Rates of death in-hospital and at 30 days were higher in patients with active cancer compared to patients with previous cancer and no cancer (7.9% vs. 4.3% vs. 2.2% and 13.8% vs. 5.2% vs. 2.6%, respectively). Rates of major bleeding were 4.8%, 2.6%, and 2.4%, respectively. Among patients with active cancer, lung or metastatic cancer were independent predictors of death; brain, hematological or gastrointestinal cancer had the highest risk of major bleeding.

Interpretation
Among patients with acute PE, those with active cancer have high risks for death or major bleeding within 30 days. These risks vary based on primary site of cancer.
Clinical trial registration: clinicaltrial.gov identifier: NCT03631810.

Graphical abstract