bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solar urticaria: clinical characteristics, treatment effectiveness, long-term prognosis, and QOL status in 29 patients
Authors: Imamura Shinya , Oda Yoshiko , Fukumoto Takeshi , Mizuno Mayuko , Suzuki Mariko , Washio Ken , Nishigori Chikako , Fukunaga Atsushi 
Published: February 2024

IntroductionSolar urticaria (SU), a relatively rare skin inflammatory and photosensitivity disease, is often resistant to standard urticaria treatment. Quality of life (QOL) among SU patients has not been extensively explored. This study was performed to clarify the clinical features and effectiveness of therapies (e.g., hardening therapy) for SU and to determine QOL among SU patients.MethodsThe authors examined the characteristics, treatments, and QOL statuses of 29 Japanese SU patients using medical records and a questionnaire approach.ResultsAmong 29 patients, H1 antihistamine therapy (H1) was effective in 22 (75.8%) patients. H2 antihistamine therapy (H2) was effective in three of seven (42.9%) patients. Ultraviolet radiation A (UVA) hardening therapy was effective in eight of nine (88.9%) patients. Visible light (VL) hardening therapy was ineffective in three of three patients. In one patient who underwent both UVA and VL hardening therapy, only UVA hardening therapy was effective. In the questionnaire, 18 patients (90%) reported some improvement compared with disease onset (four had complete remission, six had completed treatment although mild symptoms persisted, and eight were receiving treatment with moderate symptoms), whereas two patients reported exacerbation. Patients in complete remission had a mean disease duration of 4 years, whereas patients not in remission had a mean disease duration of 8.8 years. The mean Dermatology Life Quality Index (DLQI) score for the current status was 7.4. There was a correlation between DLQI and symptom/treatment status. However, neither DLQI and action spectra nor DLQI and treatments exhibited significant differences.DiscussionThe questionnaire revealed current QOL status and long-term prognosis in SU patients. Compared with disease onset, most patients showed improvement when assessed for this study. Both H1 and H2 should be attempted for all SU patients. UVA hardening therapy may be an option for SU patients with an action spectrum that includes UVA.
Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species
Authors: Brune Jakob E. , Dickenmann Michael , Sidler Daniel , Walti Laura N. , Golshayan Déla , Manuel Oriol , Haidar Fadi , Neofytos Dionysios , Schnyder Aurelia , Boggian Katia , Mueller Thomas F. , Schachtner Thomas , Khanna Nina , Schaub Stefan , Wehmeier Caroline ,   the Swiss Transplant Cohort Study
Published: February 2024

BackgroundEnterobacterales are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, Escherichia coli or Klebsiella species producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are only scarce data on frequency and impact of ESBL-UTI on transplant outcomes.MethodsWe investigated frequency and impact of first-year UTI events with ESBL Escherichia coli and/or Klebsiella species in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with Escherichia coli and/or Klebsiella species. The cohort had a median follow-up of four years.ResultsIn total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, p = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, p = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI.ConclusionFirst-year UTI events with ESBL-producing Escherichia coli and/or Klebsiella species are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival.
Iron folic acid supplementation adherence level and its associated factors among pregnant women in Ethiopia: a multilevel complex data analysis of 2019 Ethiopian mini demographic and health survey data
Authors: Temesgen Habtamu , Woyraw Wubetu , Feleke Fentaw Wassie , Mezgebu Getachew Sale , Taye Kefyalew , Awoke Tadesse 
Published: February 2024

BackgroundIron and folic acid deficiency is a worldwide public health concern, particularly in low and middle-income countries. In Ethiopia, adherence to iron and folic acid supplements is still very low. Despite the fact that a number of studies on IFA supplementation have been conducted in Ethiopia, they do not indicate a nationwide problem and do not use advanced models to demonstrate clustering effects. The purpose of this study was to assess the level of non-adherence to iron folic acid supplementation and predictors among pregnant women in Ethiopia.ObjectiveTo assess iron folic acid supplementation adherence level and its associated factors among pregnant women in Ethiopia using data from the 2019 Mini-Ethiopian demographic health survey.MethodsThe Mini Ethiopian Demographic and Health Survey 2019 data were obtained from the official database website of the Demographic and Health Survey program (http://dhsprogram.com). The analysis included a sample of 2,356 weighted study participants. A multivariable multilevel mixed-effects logistic regression model was used Variables with p-values less than 5%) was reported as statistically significant variables in the multivariable analysis.ResultsThe proportion of mothers who did not adhere to iron and folic acid supplements was 81.03% (95 %CI, 79.39, and 82.56). Birth interval less than 2 years [AOR: 2.03; 95% CI: 1.12, 3.66], women ever born less than six children [AOR: 1.99; 95% CI: 1.09, 3.64], starting ANC visit during first trimester [AOR: 2.74; 95 %CI: 1.03, 7.30], region [AOR = 0.24; 95% CI: 0.10], and having a high no ANC visit in the community [AOR = 1.77; 95% CI: 1.08, 2.88] were statistically significant factors. There was Intra-Custer Correlation (ICC = 17.72%), indicating that 17.72% variability in non-adherence levels was due to clusters.Conclusion and recommendationIn Ethiopia, nearly four out of every five pregnant women did not receive iron folic acid supplementation for the recommended periods. Birth intervals, number of children, timing of ANC visits, region, and community level no ANC service were significant factors for non-adherence IFAS. As a result, the community, govern metal and non-governmental sectors enacting on health should focus on reducing non-adherence through tailored interventions on factors that influence it.
Direct vs. redirected admission of critically ill children to PICU after interfacility transfer: a retrospective cohort study
Authors: Halgren C. , Annich G. M. , Maratta C. 
Published: February 2024

BackgroundCritically ill children must often be transported long distances for access to critical care resources in Canada. This study aims to describe and compare characteristics and outcomes in patients presenting in the community and requiring inter-facility transport and admission to a Pediatric Intensive Care Unit (PICU).MethodsThis is a retrospective cohort study of children admitted to the ICU at the Hospital for Sick Children from 2016 to 2019 after inter-facility transport. Characteristics and outcomes were compared between children admitted to the PICU within 24 h from their initial critical care transport request, and children admitted after initial redirection to a non-ICU care setting, 24–72 h from request. The primary outcome was severity of illness at PICU admission. Secondary outcomes included duration of mechanical ventilation, organ dysfunction, PICU length of stay and mortality.ResultsA total of 2,730 patients were admitted after inter-facility transport to either the medical/surgical or cardiac ICU within 72 h of initial critical care transport request. Of these children, 2,559 (94%) were admitted within 24 h and 171 (6%) were admitted between 24 and 72 h. Children admitted after initial redirection were younger and residing in more rural centers. Children who were initially redirected had lower severity of illness (PRISM-IV median score 3 vs. 5, p = 0.047) and lower risk of mortality.InterpretationInitial redirection to a non-ICU care setting rather than directly admitting to the PICU did not result in increased severity of illness or mortality. This study highlights the need to better understand which factors influence disposition decision-making at the time of initial transport request. Further research should focus on the impact of transport factors on clinical outcomes after PICU admission.
Predicting pharmacodynamic effects through early drug discovery with artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) modelling
Authors: Wu Keheng , Li Xue , Zhou Zhou , Zhao Youni , Su Mei , Cheng Zhuo , Wu Xinyi , Huang Zhijun , Jin Xiong , Li Jingxi , Zhang Mengjun , Liu Jack , Liu Bo 
Published: February 2024

Graphical AbstractMain steps used to predict PK and PD outcomes of the compounds. (Step 1) Use different AI related simulations to predict the compound’s ADME and physiochemical properties. (Step 2) Predict PK outcomes using the PBPK model. (Step 3) PD models are used to predict how changes in drug concentrations affect gastric acid secretion and gastric pH. E/E0 is the relative activity of H+/K+ ATPase by drug; ksec is the secretion rate constants for intra-gastric H+ concentration; kout is the elimination rate constant for intra-gastric H+ concentration; Hobs is the observed concentration of H+; I (Inhibition) is the current antisecretory effect (or current pH level) of the drug; Imax is the maximum possible effect (or maximum pH level) of the drug can achieve; The term (Imax -I) represents how far the current effect is from its maximum potential.
Health literacy, eHealth literacy and their association with burden, distress, and self-efficacy among cancer caregivers
Authors: Moore Chloe , Gallagher Pamela , Dunne Simon 
Published: February 2024

PurposeHealth literacy skills are vital for cancer caregivers in helping cancer survivors to navigate their diagnosis, treatment, and recovery but little is known. This study explored health literacy and eHealth literacy among cancer caregivers and the relationship between health literacy/eHealth literacy and potential associated factors.MethodsInformal caregivers who had cared for an individual with cancer completed a survey which collected demographic data and measured caregiver health literacy, eHealth literacy, self-efficacy, burden, and distress.ResultsSeven percent of caregivers had inadequate health literacy. Caregivers scored lowest on health literacy domains related to caregiver social support, information seeking and understanding care recipient preferences. eHealth literacy was associated with self-efficacy and burden while, different health literacy domains were associated with burden (‘Understanding care recipient needs and preferences’), self-efficacy (‘Cancer-related communication with the care recipient’ and ‘Understanding care recipients needs and preferences’) and distress (‘Proactivity and determination to seek information’, ‘Understanding care recipient needs and preferences’, ‘Understanding the healthcare system’).ConclusionFindings highlight key areas of need regarding cancer caregiver health literacy which future research can target. Given the observed relationship between aspects of health literacy and burden, distress and self-efficacy future work could be carried out on how to alleviate high levels of burden and distress and how to enhance self-efficacy among cancer caregivers by addressing health literacy skills.Implications for cancer survivorsFindings from this study will inform the development of health literacy interventions to support caregivers to build their health literacy skills and enable this group to better support cancer survivors as a result.
The bricolage mode of emergency medical teams in China: deficient and in urgent need of transformation—A qualitative study
Authors: Wang Li , Sheng Ya-Wei , Qi Xin-Ye , Li Fang-shi , Qiu Xin-Yu , Shao Shen , Du Yue 
Published: February 2024

IntroductionEmergency medical rescue plays a vital role in alleviating the harm of all kinds of emergencies to people's physical and mental health and life safety. The current emergency medical teams (EMTs) formation model is not unified. We focused on the disadvantages of the bricolage mode of China EMTs and put forward empirical-based countermeasures to improve the emergency management ability of EMTs.MethodsFrom March to September 2022, 23 leaders of EMTs in North China (Tianjin) were selected by objective sampling method to conduct one-to-half structured in-depth interviews. Nvivo12.0 software was used for three-level coding. The disadvantages of the bricolage model of EMT were analyzed.ResultsBased on the three-level coding, 150 initial concepts, 36 sub-coding, 17 main coding, six categories, and two core categories were sorted out. Management structure, internal stability, and support are recognized as the crucial elements armed with the EMTs.DiscussionThe bricolage EMTs have disadvantages such as a chaotic management structure, weak internal stability, and inadequate support. It is necessary to construct full-time EMTs that incorporate a standardized personnel admission mechanism, full-time training and exercise mechanism, diversified incentive mechanism, and multi-agent cooperation mechanism, etc.
Partnership-building considerations for implementation science in learning health systems: a case study of the Implementation Science Collaborative in Alberta, Canada
Authors: Brooks Stephanie P. , Alba Cody , Thomson Denise , Davison Sara N. , Storey Kate 
Published: February 2024

IntroductionImplementation of health innovations is inherently collaborative, requiring trans-sectoral partnerships between implementation researchers, innovation teams, and implementation practitioners. Implementation science has been shown to improve implementation successes; however, challenges that hinder partnerships to advance implementation science continue to persist. Using a whole-system approach to assess and respond to implementation science partnership barriers may shed light on effective responses.MethodsWe conducted a case study of Alberta's learning health system, using semi-structured group and individual interviews to create a nuanced understanding of the considerations required for implementation research collaborations. We interviewed 53 participants representing 21 offices in the health system, academia, professional associations, and government who regularly plan, evaluate, and/or study health system implementation initiatives in Alberta. Using the Partnership Model for Research Capacity Building, we identified current facilitators and challenges for partnerships for conducting and using implementation science, at different levels of Alberta's health-research ecosystem.ResultsAlberta's healthcare system is well set up to readily embed intervention effectiveness and efficacy research. Infrastructure was also in place to strengthen implementation practice. However, weaknesses around exchanging knowledge and skills, providing feedback and mentoring, and accommodating diversity affected the ability of both individuals and teams to build implementation science capacity. Without this capacity, teams could not participate in embedded implementation research collaborations. We report the response of the Alberta Strategy for Patient-Oriented Research SUPPORT Unit to these barriers to provide practical guidance on various program options to strengthen individual- and organization-level implementation science capacity.DiscussionThis study applied a whole-system approach to assess factors across Alberta's health-research ecosystem, which affect partnerships to advance implementation science. Our findings illustrated that partnership considerations go beyond interpersonal factors and include system-wide considerations. With the results, health organization leaders have (1) a method for assessing organizational capability to readily embed implementation research and (2) a catalog of potential responses to create conditions to readily engage with implementation science in their day-to-day implementation processes.
Uma diretriz para a transição da tecnologia multiuso para single-use na etapa de formulação de um produto imunobiológicoIntrodução: O avanço da inovação tecnológica é premente, e assim as empresas devem manter-se na vanguarda de novas tendências científi
Authors: De Oliveira Daniele Alves , De Magalhães Jorge Lima 
Published: February 2024

Introdução: O avanço da inovação tecnológica é premente, e assim as empresas devem manter-se na vanguarda de novas tendências científicas e mercadológicas, mesmo que não venham a implementar todas as novidades de imediato, mas que saibam como trabalhar com elas. Ao desenvolver uma inovação, é preciso que ela seja tecnologicamente viável, condizente com a estratégia de negócios da empresa, convertida em valor para o cliente e em oportunidade de mercado para a empresa. Portanto, não basta reconhecer o imperativo da mudança e desejar fazê-la, é indispensável planejar a mudança da forma mais adequada, a fim de que possibilitem a aplicação prática para a estruturação em modelos de processos de inovação, que compreendem procedimentos e políticas para o desenvolvimento de inovações. Objetivo: Propor uma Diretriz para transição da Tecnologia Multiuso (MUT) para a Tecnologia Single-Use (SUT) na etapa de Formulação de um Imunobiológico, considerando como modelo uma vacina produzida por uma Indústria Biofarmacêutica Nacional. Metodologia: Foi considerada a abordagem Design Thinking (DT) – inspiração, ideação/prototipação e implementação para construção dos desenhos vislumbrados na SUT, seguido pela avaliação dos documentos internos da organização com foco nos detalhes do produto e requisitos de qualidade para as Boas Práticas de Fabricação (BPF). Seguidamente, aplicada a avaliação dos riscos do processo na SUT através da ferramenta de Análise de Modo e Efeito de Falha (Failure Mode and Effects Analysis - FEMEA). Finalmente proposta a diretriz de implementação. Resultados: Obtido protótipos na SUT considerando o processo de Formulação da vacina e ainda da Solução Intermediária consumida nesta etapa, bem como a análise de risco da mudança e a proposição da Diretriz para alteração da MUT para a SUT na etapa de Formulação de um Imunobiológico. Conclusão: Os sistemas para bioprocesso descartáveis, feitos essencialmente de plástico, estão a caminho de usurpar o atual domínio dos sistemas fixos de bioprocessamento de aço inoxidável, por diversas facilidades e benefícios existentes. Os princípios adotados, no processo apresentado, podem ser aplicados na etapa de Formulação de outro Imunobiológico, desde que as interdependências existentes sejam identificadas e consideradas, e desta forma as empresas alcançarão êxito na mudança.
MODEL PEMBELAJARAN RECIPROCAL TEACHING : APAKAH MEMPENGARUHI MOTIVASI BELAJAR MATEMATIKA?
Authors: Rezki Rezki , Noviantari Ika , Susanti Dwi , Hermansyah Hermansyah 
Published: February 2024

AbstractThe reciprocal teaching-learning model was applied to determine its effect on student’s motivation to learn mathematics at SMP Negeri 11 Tarakan. This study used a quantitative approach to the type of quasi-experimental research. The data collection technique used is a motivational questionnaire to learn mathematics. The sample in this study were students of class VIII-1 and class VIII-2 of SMP Negeri 11 Tarakan. Simple regression analysis was used as a data analysis technique. Based on data analysis, it was found that the reciprocal teaching-learning model had a positive effect on student’s motivation to learn mathematics at SMP Negeri 11 Tarakan.Keywords: Reciprocal Teaching, Mathematic Learning MotivationAbstrakModel pembelajaran reciprocal teaching diterapkan untuk mengetahui pengaruhnya terhadap motivasi belajar matematika siswa SMP Negeri 11 Tarakan. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen semu. Teknik pengumpulan data yang digunakan berupa angket motivasi belajar matematika. Sampel dalam penelitian ini adalah siswa kelas VIII-1 dan kelas VIII-2 SMP Negeri 11 Tarakan. Analisis regresi sederhana digunakan sebagai teknik analisis data. Berdasarkan analisis data diperoleh bahwa model pembelajaran reciprocal teaching berpengaruh positif terhadap motivasi belajar matematika siswa SMP Negeri 11 Tarakan.Kata kunci: Reciprocal Teaching, Motivasi Belajar Matematika
MEMPERSIAPKAN SISWA MERAIH PRESTASI DALAM KOMPETISI MATEMATIKA: APA YANG DILAKUKAN GURU?
Authors: Simamora Rustam Effendy , Suardi Zainuddin , Widyawati Eka 
Published: February 2024

This research aimed to describe the role undertaken by teachers at SMP Negeri 1 Tarakan, one of the public junior high schools in Tarakan, Indonesia, in preparing their students to succeed in mathematics competitions. This qualitative research employed a case study approach. The data collection techniques included interviews, documentation, and observation. The data analysis consisted of several interactive steps: preparing the collected data, reading it repeatedly to comprehend it, coding, identifying and testing themes through triangulation and member checking, describing the established themes, interpreting the themes and descriptions, and drawing conclusions. We also conducted peer debriefing during coding and writing research reports. Based on the data analysis, the findings regarding the role of teachers in preparing students for participation in mathematics competitions in the school consisted of two categories: students selection and coaching. Mathematics teachers select students through two main steps: set criteria and analyze students’ mathematical abilities. While coaching students to prepare for competition participation, teachers employed a personalized approach, facilitated student learning, motivated students, and utilized resources and facilities.Keywords: case study, mathematics competition, mathematics in junior high school, teacher roles. Penelitian ini bertujuan untuk mendeskripsikan hal yang dilakukan oleh guru di SMP Negeri 1 Tarakan dalam mempersiapkan siswanya untuk meraih prestasi dalam kompetisi Matematika. Jenis penelitian ini adalah kualitatif dengan pendekatan studi kasus. Adapun teknik pengumpulan data adalah wawancara, dokumentasi, dan observasi. Analisis data yang dilakukan terdiri dari beberapa langkah interaktif: mempersiapkan data yang telah terkumpul, membaca berulang-ulang untuk memahami semua data, melakukan pengkodean, menentukan tema dan mengujinya melalui triangulasi dan memeriksa anggota, mendeskripsikan tema yang sudah ditetapkan, menginterpretasi tema dan deskripsi tersebut, dan menarik kesimpulan. Sepanjang melakukan pengkodean dan penulisan laporan penelitian, kami juga melakukan peer debriefing. Berdasarkan hasil analisis data, temuan tentang bagaimana peran guru dalam mempersiapkan siswa untuk mengikuti kompetisi Matematika di sekolah tersebut terdiri dari dua kategori: memilih siswa dan melakukan pembinaan. Guru Matematika memilih siswa dengan dua langkah utama, yaitu menetapkan syarat dan menganalisis kemampuan Matematika siswa. Selama membina siswa untuk mempersiapkan mereka mengikuti kompetisi, guru melakukan pendekatan personal, memfasilitasi siswa dalam belajar, memotivasi siswa, dan memanfaatkan sarana dan prasarana.Kata kunci: kompetisi Matematika, Matematika SMP, peran guru, studi kasus.