bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrodeposition of polyaniline on reduced graphene oxide/cotton yarn with tunable electrochemical performance for flexible textile supercapacitors
Authors: Li Lin , Du Dou , He Chengen , Han Kun , Xu Weilin , Xia Liangjun , Cai Guangming , Cui Xun , Chen Yihuang , Yu Lianqing , Kong Lingxue 
Published: October 2023

Abstract

Graphene/cotton fibres, an all-organic and all-textile combination, show significant promise in the realm of wearable energy storage by reason of their light weight, low cost, porous structure, and exceptional integration ability into wearable systems. However, the use of eco-unfriendly reductants and limited specific capacity caused by a standalone electric double-layer capacitor (EDLC) hindered their application. Herein, an environmentally friendly and rapid hydrothermal-electrodeposition method was proposed to fabricate cotton yarns wrapped with polyaniline (PANI) decorated reduced graphene oxide (rGO) without using any chemical reductants and oxidants. The PANI/rGO/cotton (PRC) yarn demonstrated a tunable energy storage capacity through the regulated aniline content in electrolyte and current sweep during the electrodeposition. The PRC yarn electrode exhibits a hierarchical porous conductive layer, tightly bound heterogeneous interface, and synergistic energy storage contribution and then exhibits a compelling capacitance of 81.2 mF cm−1 at 0.2 mA cm−1. The yarn supercapacitor based on PRC electrode shows a good capacitance (19.8 mF cm−1 at 0.08 mA cm−1), excellent energy-power density (2.7 μWh cm−1 at 40 μW cm−1), and great capacitance retention (83% after 8000 cycles). This environmentally friendly synthesis of PANI/rGO/ cotton yarns brings new insights into the development of textile-based wearable energy application.
A Price-based D2D Resource Allocation Scheme in Smart Manufacturing Scenarios
Authors: Li Shiyong , Zhang Xiaofeng , Liu Huan , Sun Wei 
Published: October 2023

Abstract

Smart Manufacturing has become a popular topic due to the growth of Internet of Things (IoT) and Cloud Manufacturing, which is driving traditional manufacturing companies to migrate towards digitization and intelligence. Device to Device (D2D) facilitates communication between terminal devices and improves output and operational efficiency. Firstly, by using the utility theory of microeconomics, this paper constructs a novel utility-oriented resource allocation model and addresses the resource allocation problem for D2D communication. This paper also proposes an interesting price-based resource allocation scheme along with an improved gradient descent method and proves the stability of the price-based resource allocation technique based on the Lyapunov stability theory. The simulation results demonstrate that the two proposed algorithms can achieve the equilibrium which is also the optimum of the resource allocation model, and that the gradient descent method is outperformed by the price-based mechanism method in terms of stability and convergence speed.
Cancer-derived exosomal circTMEM56 sensitize HCC radiotherapy by augment cGAS-STING pathway in dendritic cells
Authors: Ke Ai-Wu , Gao Chao , Wang Si-Wei , Zheng Yi-Min , Lu Jia-Cheng , Huang Xiao-Yong , Zhou Jian , Fan Jia , Zeng Zhao-Chong , Du Shi-Suo , Zhang Peng-fei 
Published: October 2023

Abstract
Background：Dysregulation of circRNAs in cancer cells can deregulate host immune surveillance, however, their roles and mechanisms of radiotherapy (RT)-induced immune effects remain elusive.
Method：By comparing tissues and serum from patients with and without abscopal effect (AE) after RT, we reported hsa_circ_0005720 (circTMEM56) was elevated in patients with AE, and circTMEM56 level related to the survival and recurrence of HCC patients. Using cells and mice with cGAS or Sting deficiency, we demonstrated that exosomal circTMEM56 level was positively associated with response to RT and promoted dendritic cell (DC) proliferation and augmented type I interferons (IFN-I) secretion.
Results: Mechanistically, circTMEM56 bolstered the cGAS/STING induced type I IFN signaling to partake in the RT-resetting the tumor microenvironment through a miR-136-5p/STING axis. Importantly, the administer of exosomal circTMEM56 ameliorated the SBRT response in mice with low level of circTMEM56, and patients with low circTMEM56 are poorly responsive to RT plus anti-PD1 therapy (Clinical trials NCT03857815 and ChiCTR2200057338). Thus, we not only mechanistically elucidated a molecular axis by which circTMEM56 intensified the RT-reset tumor microenvironment, but also offered a novel effective reinforcing adjuvant for HCC RT.
Organic fertilization increases the abundance of bacteria, fungi, and protists and their co-occurrence complexity in acidic soils
Authors: Li Ke , Xing Xiaoyi , Wang Shubin , Liao Rujia , Hassan Muhammad Umair , Aamer Muhammad , Barbanti Lorenzo , Xu Huifang 
Published: October 2023

Abstract
Background and aims
Organic fertilization highly influences microbial populations and diversity in the soil. This study aimed to understand how organic fertilizer application affects bacterial, fungal, and protist communities in acidic soils and thus reshapes their interactions.
Methods
Soil samples were collected from a long-term field experiment consisting of four fertilization treatments: no fertilization (control), inorganic fertilization (NPK), organic fertilization (OM), and their combination (NPKOM). The abundance and composition of bacterial, fungal, and protist communities were analyzed.
Results
The total abundance of bacteria, fungi, and protists increased by at least 2.95, 3.47, and 0.66 times after organic fertilizer application. The composition of the bacterial, fungal, and protist communities was significantly different between the inorganic and organic fertilization treatments. Organic fertilization increased the complexity of co-occurrence among bacteria, fungi, and protists by increasing the number of keystone taxa and inter-kingdom associations. The abundance, community structure, and keystone taxa of bacteria, fungi, and protists significantly correlated with soil organic matter, total phosphorus, and available phosphorus content.
Conclusions
Soil pH, organic matter, and phosphorus levels were important factors in determining bacterial, fungal, and protist community structures and the complexity of microbial co-occurrence in acidic soils. This study provided insights into the relationship between agricultural management practices and soil bacterial, fungal, and protist communities.
Efficacy of gamithromycin injection against cattle respiratory disease
Authors: Zhang Pei Yang , Gao Yan Yan , Li Peng Peng , Dong Yang Mei , Sang Ka Na , Zhang Cong , Hou Lin , Li Huan Juan , Bian Kui , Zhou De Gang 
Published: October 2023

Abstract
Background
Bovine respiratory disease (BRD) is a highly prevalent and economically costly disease affecting cattle. Extensive research has been carried out to elucidate the economic impact of the disease, therapeutic modalities and preventive measures. This disease has a detrimental effect in terms of increased mortality, escalating treatment costs and significant production losses.
Results
Given the far-reaching impact of BRD, further scientific research into effective prevention and intervention strategies is imperative to mitigate its adverse effects on the livestock industry. Gamithromycin is a new semi-synthetic macrolide animal-specific antibiotic, mainly for treating respiratory diseases caused by bacteria in cattle, with the characteristics of rapid absorption and high bioavailability. To determine the therapeutic effect of gamithromycin injection at the recommended dose on the target indications in the field, Sixty sick, diseased cattle meeting the study eligibility criteria were randomly divided into two groups (30 cattle in each group): a test group, which received gamithromycin injection at a dose of 6 mg/kg body weight (BW); and a control group, which received tulathromycin injection at the recommended dose (2.5 mg/kg BW). During the test period, the following observations were made on the sick cattle: from day 0 to day 14 of administration, the injection site was observed daily for any reaction, body temperature was measured, and mental status and respiratory symptoms were scored according to the criteria.
Conclusions
The results showed that the study drug gamithromycin had an excellent therapeutic effect on BRD. Gamithromycin can effectively clear BRD associated with the main pathogenic bacteria, such as P. multocida, Staphylococcus haemolyticus, S. pneumoniae, and other pathogenic bacteria can be effectively cleared. Most sick cattle recovered to normal 4–5 days after administration, with an effective rate of more than 90% and a cure rate of up to 80%, comparable to that with injection with the control veterinary drug, tulathromycin (P > 0.05).
The prevalence and influencing factors of cognitive frailty in patients with maintenance hemodialysis in China: a meta-analysis
Authors: Wei Xinghong , Liu Qin , Peng Junjie , Chang Renjie 
Published: October 2023

Abstract
Objective:To investigate the prevalence and influencing factors.
Methods: CNKI, VIP, Wanfang Data Knowledge Service platform(Wanfang), China Biomedical Literature Database (CBM), PubMed, Embase, Cochrane Library, Web of Science were searched. Cross-sectional studies, case-control studies, and cohort studies on factors influencing cognitive frality in maintenance hemodialysis patients were collected and published between 2000 and October 2023. Two researchers independently screened literature and extracted data to evaluate the literature quality of the included studies. Stata15.0 software was used to conduct a meta-analysis on the prevalence and influencing factors of cognitive frailty in maintenance hemodialysis patients in China.
Results: A total of 10 literatures on cognitive frailty were included in this study, including 659 patients with cognitive frailty, involving 25 influencing factors. The results of meta-analysis showed that the prevalence of cognitive frailty in maintenance hemodialysis patients in China was 25.6% (95%CI:21%~30.3%). Age (OR=0.542,95%CI (0.294, 0.789), P<0.001), education level (OR=-1.556,95%CI (-2.113, -1.000), P<0.001), comorbidities (OR=0.909,95%CI (0.295, 1.524), P=0.004], stroke history (OR=1.046, 95%CI (0.509, 1.5834), P<0.001) were the influential factors for cognitive frailty in maintenance hemodialysis patients in China.
Conclusion: The prevalence rate of cognitive frailty in maintenance hemodialysis patients in China is high (25.6%), and age, educational level, comorbidities and stroke history are the influencing factors of cognitive frailty in maintenance hemodialysis patients in China.
Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes
Authors: Ittleman Benjamin , Lowenstein Sarah , Edwards Lindsay , Caris Elizabeth , Bhat Aarti , Conwell Jeffrey , Lewin Mark , Arya Bhawna 
Published: October 2023

Abstract

Background:
Despite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) is associated with worse outcomes in HLHS. We aim to determine if right ventricle functional parameters and TR on fetal echocardiogram are associated with postnatal outcomes in HLHS patients.
Methods:
Retrospective review was performed on all fetuses with HLHS from 2014–2022 at our institution. Initial and follow up fetal echocardiogram measurements of right ventricular myocardial performance index (MPI), fractional area change (FAC) and global longitudinal strain (GLS) were retrospectively measured. The presence and severity of TR was recorded from the fetal echocardiogram reports. Postnatal outcomes including transplant-free survival, hospital length of stay > 30 days after initial palliation and need for bidirectional Glenn at < 4 months were reviewed.
Results:
Forty-three subjects met inclusion criteria. Mean gestational age at presentation was 26.1 ± 5.9 weeks. Nine subjects died and 3 required transplants. Initial fetal echocardiogram MPI was significantly lower (better) (0.36 ± 0.06 vs 0.44 ± 0.11; p = < 0.001) and FAC was significantly higher (better) 45 ± 6% vs 40 ± 8%; p = 0.035) in transplant-free survivors. Fetal right ventricular GLS and presence of TR were not associated with any postnatal outcomes.
Conclusion:
In fetuses with HLHS, abnormal MPI and right ventricular FAC are associated with decreased transplant-free survival. There was no observed association between GLS and any of the postnatal variables. To our knowledge this is the first study examining fetal right ventricular GLS in HLHS patients and its link to postnatal outcomes.
Investigation the effect of electrode materials on arc discharge machining of 40% SiCp/Al composites
Authors: Tang Lin , Zhang Yunsong , Cao Tong , Xue Runrong , Zhang Jingjing , Zhang Jun 
Published: October 2023

Abstract

In order to explore the influence of electrode materials on arc discharge machining, four kinds of materials (copper, 45 steel, W70Cu30 and graphite) were used as electrodes, the simulations mathematical model and geometric model of arc discharge temperature field for different electrode materials were established respectively. Else, the simulation of arc discharge temperature field was conducted. The simulation results show that the depths of graphite, W70Cu30, 45 steel and copper electrode are from shallow to deep in turn. Under the conditions of discharge voltage 25V, feed speed 30mm/min and working medium water-based working fluid, comparative experiments of grooves with depth of 3mm and length of 60mm were carried out. The test results show that compared with other materials, the removal rate of 40%SiCp/Al composites processed by graphite electrode is up to 765.55mm3/min, the relative tool wear rate is reduced to 4.61%. The results show that graphite electrode has high processing efficiency and good processing quality.
Application of whole-exome sequencing technology in clarifying 269 cases of fetal skeletal system disorders
Authors: ge yijun , yuan huizhen , zeng baitao , yang bicheng , zhang liuyang , liu yanqiu , zou yongyi 
Published: October 2023

Abstract
Objective
This study aimed to evaluate the enhancement of whole-exome sequencing technology for the detection of fetal skeletal dysplasias (SDs) in pregnant women with suspected fetal skeletal system abnormalities and explore its potential for genetic mapping.
Methods
Between February 2021 and January 2023, we performed whole-exome sequencing on 269 pregnant women with prenatal ultrasound indications of fetal skeletal system abnormalities. We collected genetic reports and analyzed the results.
Results
Whole-exome sequencing demonstrated a 26.41% (14/53) increase in detection rates for fetal skeletal abnormalities initially detected by ultrasound. It also facilitated the identification of causative genes and provided a deeper understanding of the genetic characteristics compared to traditional methods such as karyotype analysis and chromosome microarray analysis (CMA).
Conclusion
In cases where traditional diagnostic techniques, such as karyotype analysis combined with CMA, fail to determine the etiology of fetal ultrasound-indicated skeletal system abnormalities, whole-exome sequencing offers a novel diagnostic approach. This technology has the potential to provide patients with valuable diagnostic insights, assisting in clarifying the underlying causes of these abnormalities and guiding appropriate prenatal care decisions.
Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer
Authors: Hoffmann Helene , Wartenberg Martin , Vorlova Sandra , Karl-Schöller Franziska , Kallius Matthias , Reinhardt Oliver , Burkhardt Verena , Gätzner Sabine , Scheld Daniela , Zernecke Alma , Herterich Sabine , Ergün Süleyman , Rosenwald Andreas , Henke Erik 
Published: October 2023

Abstract
Blood vessels in tumors are often dysfunctional. This impairs the delivery of therapeutic agents to and distribution among the cancer cells and subsequently reduces treatment efficacy. The dysfunctional vessel phenotypes are attributed to aberrant pro-angiogenic signaling, and anti-angiogenic agents can ameliorate traits of vessel dysfunctionality. However, they simultaneously reduce vessel density and thereby impede drug delivery and distribution. Exploring possibilities to improve vessel functionality without compromising vessel density in the tumor microenvironment, we evaluated transcription factors (TFs) involved in epithelial-mesenchymal transition (EMT) as potential targets. Based on similarities between EMT and angiogenic activation of endothelial cells, we hypothesized that these TFs, Snai1 in particular, might serve as key regulators of vessel dysfunctionality. In vitro experiments demonstrated that Snai1 (similarly Slug and Twist1) regulates endothelial permeability, permissiveness for tumor cell transmigration, and tip/stalk cell formation. Endothelial-specific, heterozygous knock-down of Snai1 in mice improved vascular quality in implanted tumors. This resulted in better oxygenation and reduced metastasis. Notably, the tumors in Snai1KD mice responded significantly better to chemotherapeutics as drugs were transported into the tumors at strongly increased rates and more homogeneously distributed. Thus, we demonstrate that restoring vessel homeostasis in malignant cancers without affecting vessel density is feasible. Combining such vessel re-engineering with anti-cancer drugs allows for strategic treatment approaches that reduce treatment toxicity on non-malignant tissues.
Conditional survival analysis and dynamic prediction of long-term survival in Merkel Cell Carcinoma patients
Authors: Zhang Jin , Xiang Yang , Chen Jiqiu , Liu Lei , Liu Qingsong , Jin Jian , Zhu Shihui 
Published: October 2023

Abstract
Background:
Merkel cell carcinoma (MCC) is a rare type of invasive neuroendocrine skin malignancy with high mortality. However, with years of follow-up, what is the actual survival rate and how can we continually assess an individual's prognosis? The purpose of this study was to estimate conditional survival (CS) for MCC patients and establish a novel CS-based nomogram model.
Methods:
This study collected MCC patients from the Surveillance, Epidemiology, and End Results (SEER) database and divided these patients into training and validation groups at the ratio of 7:3. CS refers to the probability of survival for a specific timeframe (y years), based on the patient's survival after the initial diagnosis (x years). Then, we attempted to describe the CS pattern of MCCs. The Least absolute shrinkage and selection operator (LASSO) regression was employed to screen predictive factors. The Multivariate Cox regression analysis was applied to demonstrate these predictors’ effect on overall survival and establish a novel CS-based nomogram.
Results:
A total of 3843 MCC patients were extracted from the SEER database. Analysis of the CS revealed that the 7-year survival rate of MCC patients progressively increased with each subsequent year of survival.The rates progressed from an initial 41% to 50%, 61%, 70%, 78%, 85%, and finally to 93%. And the improvement of survival rate was nonlinear. The LASSO regression identified five predictors including patient age, sex, AJCC stage, surgery and radiotherapy as predictors for CS-nomogram development. And this novel survival prediction model was successfully validated with good predictive performance.
Conclusion:
CS of MCC patients was dynamic and increased with time since the initial diagnosis. Our newly established CS-based nomogram can provide a real-time estimate of survival, which has implications for follow-up guidelines and survivorship planning, enabling clinicians to guide treatment for these patients better.
Using Recasts to Enhance Students English Question Production: Secondary School Students in Focus
Authors: Addis Ketema , Yigzaw Abiy , Tefera Ebabu 
Published: October 2023

Abstract
Research on recasts has gotten increasing attention from SLA researchers ever since the 1990s. However, the studies on the effectiveness of recasts had inconsistent findings and are still debatable in what way recasts facilitate L2 learning. The study aims to examine the effects of recasts on English question production by adopting a pretest, posttest, and delayed posttest design. Forty-five grade eleven students participated in the study and were grouped into three developmental stages of the target structure, the intended framework. Most students exhibited substantial preferences for recasts over other types of feedback, with more than half of the students in each group reporting noticing the recasts in their learning journals. Primed production played a better role than uptake. Successful uptake was somewhat infrequent and was not significantly correlated with any group's noticing of recasts. It had a significant impact on the question development of lower-level and intermediate-level students but not on higher-level students' accuracy of question production. In contrast, it was revealed that primed production of question forms was strongly correlated with noticing recasts for all groups, and it was facilitative of subsequent L2 development in all groups. It concludes that recasts provided in dyadic interactions have facilitated the English question production by Ethiopian EFL learners at different stages.
Abnormal development of skeletal muscle with higher lipid accumulation in low birth weight goats
Authors: Song Huihui , Hao Zhuohang , Feng Hehan , Yao Bingpeng , Luo Nanjian , Li Rui , Zhao Yongju , Chen Xiaochuan 
Published: October 2023

AbstractLow birth weight (LBW) impairs the development and health of livestock by affecting postnatal growth performance and metabolic health in adulthood. Previous studies on indigenous goats in Southwest China showed that LBW goat kids had higher mortality and morbidity rates, including hepatic dyslipidemia and liver damage. However, the lipid metabolism in the skeletal muscle of LBW offspring remains unclear. Therefore, we investigated the lipid content in skeletal muscle and the regulatory mechanism by comparing LBW goats with normal birth weight (NBW)goats. We found that the levels free fatty acids in both plasma and skeletal muscle were significantly higher in LBW goats than in NBW goats (p< 0.05). Meanwhile, transcriptome analysis revealed impairments of lipid metabolism, oxidative stress, and insulin signaling in LBW goats. Correspondingly, Kyoto Encyclopedia of Genes and Genomes annotation further indicated that lipid peroxidation and the antioxidant pathway were involved in skeletal muscle lipid dysregulation. Moreover, lipid accumulation was associated with the upregulation of genes related to fatty acid uptake and transport (FABP3), fatty acid oxidation (PPARA), triacylglycerol synthesis (LPIN1andDGAT1), oxidative stress (ANKRD2), and insulin resistance (PGC1α). These results suggest that LBW goat kids have higher lipid accumulation in skeletal muscle, which may contribute to metabolic disease and poor growth performance in later life.