bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural processes linking joint hypermobility and anxiety: key roles for the amygdala and insular cortex
Authors: Kampoureli Christina N. , Rae Charlotte L. , Gould Van Praag Cassandra , Harrison Neil A. , Garfinkel Sarah N. , Critchley Hugo D. , Eccles Jessica A. 
Published: February 2025

Background
Anxiety symptoms are elevated among people with joint hypermobility. The underlying neural mechanisms are attributed theoretically to effects of variant connective tissue on the precision of interoceptive representations contributing to emotions.

Aim
To investigate the neural correlates of anxiety and hypermobility using functional neuroimaging.

Method
We used functional magnetic resonance neuroimaging to quantify regional brain responses to emotional stimuli (facial expressions) in people with generalised anxiety disorder (GAD) (N = 30) and a non-anxious comparison group (N = 33). All participants were assessed for joint laxity and were classified (using Brighton Criteria) for the presence and absence of hypermobility syndrome (HMS: now considered hypermobility spectrum disorder).

Results
Participants with HMS showed attenuated neural reactivity to emotional faces in specific frontal (inferior frontal gyrus, pre-supplementary motor area), midline (anterior mid and posterior cingulate cortices) and parietal (precuneus and supramarginal gyrus) regions. Notably, interaction between HMS and anxiety was expressed in reactivity of the left amygdala (a region implicated in threat processing) and mid insula (primary interoceptive cortex) where activity was amplified in people with HMS with GAD. Severity of hypermobility in anxious, compared with non-anxious, individuals correlated with activity within the anterior insula (implicated as the neural substrate linking anxious feelings to physiological state). Amygdala-precuneus functional connectivity was stronger in participants with HMS, compared with non-HMS participants.

Conclusions
The predisposition to anxiety in people with variant connective tissue reflects dynamic interactions between neural centres processing threat (amygdala) and representing bodily state (insular and parietal cortices). Correspondingly, interventions to regulate amygdala reactivity while enhancing interoceptive precision may have therapeutic benefit for symptomatic hypermobile individuals.
Application of strongly intensive quantity in the investigation of forward-backward correlation in UrQMD simulated pp collisions at √s=13 TeV
Authors: Bhattacharyya Swarnapratim 
Published: February 2025

Abstract
This work utilizes the novel approach of the strongly intensive quantity Σ_FBto investigate the forward-backward multiplicity correlation in UrQMD simulated pp collisions at √s=13 TeV. Evidence of forward-backward correlation has been noted in UrQMD simulated pp collisions at different separation between the forward and backward pseudo-rapidity zones. The strongly intensive quantity Σ_FBhas been found to increase slowly with increasing the separation (η_gap) between the forward and backward pseudo-rapidity zones. Comparison of this analysis with PYTHIA tuned with Monash 2013 simulated values, EPOS3 simulated values and ALICE collaboration values (for minimum bias events) have also been presented.
Update on Antiseizure Medications 2025
Authors: Abou-Khalil Bassel W. 
Published: February 2025

ABSTRACT

OBJECTIVE
This article is an update from the article on antiseizure medication therapy published in the three previous Continuum issues on epilepsy and is intended to cover the vast majority of agents currently available to neurologists in the management of patients with epilepsy. This article addresses antiseizure medications individually, focusing on key pharmacokinetic characteristics, indications, and modes of use.

LATEST DEVELOPMENTS
Since the most recent version of this article was published, one new antiseizure medication, ganaxolone, has been approved by the US Food and Drug Administration (FDA), and the indications of some approved medications were expanded. Older antiseizure medications are effective but have tolerability and pharmacokinetic disadvantages. Several newer antiseizure medications have undergone comparative trials demonstrating efficacy equal to and tolerability at least equal to or better than older antiseizure medications as first-line therapy for focal epilepsy. These agents include lamotrigine, oxcarbazepine, levetiracetam, topiramate, zonisamide, and lacosamide. Pregabalin was found to be less effective than lamotrigine. Lacosamide, pregabalin, and eslicarbazepine have undergone successful trials of conversion to monotherapy for focal epilepsy. Other newer antiseizure medications with a variety of mechanisms of action are suitable for adjunctive therapy.

ESSENTIAL POINTS
Knowledge of antiseizure medication pharmacokinetics, efficacy, and tolerability profiles facilitates the choice of appropriate antiseizure medication therapy for patients with epilepsy. Rational antiseizure medication combinations should avoid antiseizure medications with unfavorable pharmacokinetic interactions or pharmacodynamic interactions related to mechanism of action.
The Demographic and Socioeconomic Consequences of Restricting Access to Marriage for Young Immigrant Women in Denmark
Authors: Cuzulan Bojana , Schultz-Nielsen Marie Louise , Fallesen Peter 
Published: February 2025

Abstract
In July 2002, Danish reforms limited the marriage opportunities for all Danish and non–European Union (EU) citizens younger than 24 living in Denmark who wished (or whose parents wished for them) to marry someone from outside the EU. Before the reform, more than 80% of first- and second-generation immigrants from outside the EU married spouses from their parents’ origin countries; the reform drastically changed their marriage market. We examine the policy's effects on subsequent marriage behavior, the transition to motherhood, human capital accumulation, and labor market activities using full-population administrative data on 578,380 Danish-born first- and second-generation non-EU immigrants born in 1972–1990 and a difference-in-differences design. We find that the policy delayed marriages among individuals with an immigrant background, extended premarital cohabitation, changed the composition of spouses, and delayed and decreased in-wedlock fertility. Finally, the duration of obtained formal education increased. Our results emphasize that reforms constraining access to external marriage markets can have lasting impacts on marriage demographics among immigrants.
TAZ interactome analysis using nanotrap-based affinity purification–mass spectrometry
Authors: Kelebeev Jonathan , MacKeracher Anastasia , Miyake Tetsuaki , McDermott John C. 
Published: February 2025

ABSTRACT
Characterization of protein–protein interactions (PPIs) is a fundamental goal in the post-genomic era. Here, we document a generally applicable approach to identify cellular protein interactomes using a combination of nanobody-based affinity purification (AP) coupled with liquid chromatography and tandem mass spectrometry (LC–MS/MS). The Hippo signaling regulator TAZ (also known as WWTR1) functions as a transcriptional co-repressor or activator depending on its PPI network; we therefore undertook an unbiased proteomic screen to identify TAZ PPIs in striated muscle cells. A GFP nanotrap-based AP approach coupled with protein identification through LC–MS/MS was used to document a comprehensive list of known and novel TAZ interactome components. Informatic analysis of the interactome documented known components of the Hippo signaling pathway and multiple epigenetic regulators such as the NuRD, FACT and SWI/SNF complexes and the pro-myogenic CARM1 methyltransferase. Hippo pathway reporter gene (HOP/HIP) analysis indicated that CARM1 represses TAZ transcriptional co-activator function, promoting TAZ Ser89 phosphorylation and TAZ cytoplasmic sequestration. MS analysis revealed that CARM1 dimethylates TAZ at Arg77 in a PGPR*LAGG consensus peptide, resulting in enhanced TAZ Ser89 phosphorylation. These studies underline the utility of a nanobody-based AP approach for interactome analysis.
Terrorism as a factor geopolitical restructuring in the Sahel region
Authors: Kante Mady Ibrahim 
Published: February 2025

Since the beginning of the new millennium, extremism has emerged as a major challenge facing the African continent. This phenomenon significantly impedes economic and political development, prompting individual states to fight terrorism through various initiatives. Despite these efforts, tangible results have been elusive due to the transfer of extremist ideologies across state borders, leading to external interventions under the guise of the “fight against terrorism in the Sahel.” Although jihadist terrorist groups have long been present in Africa, the Sahel countries and African organizations have not adopted effective strategies to combat violent extremism. Since 2011, terrorist organizations have seized control of areas in the Sahel, with Boko Haram conducting numerous operations that threaten regional security and stability.
In response, African organizations such as the African Union and regional bodies have implemented policies and initiatives aimed at curbing the spread of violent extremism through military interventions and economic and social development projects in the Sahel. These efforts include alliances like the Lake Chad Basin Commission and G5 Sahel, comprising five Sahel countries. Given the regional and international ramifications of extremism on Western interests and economically powerful states, African nations and organizations have engaged in serious cooperation with the international community and major powers. This collaboration includes efforts with the United Nations, France, and other entities in peacekeeping missions and initiatives to combat terrorism and extremism.
Keywords: Africa, Sahel, geopolitics, terrorism, war, counterterrorism, military intervention, security.
Modular Cleaning Program w praktyce
Authors: Węgrzyn-Jankowiak Paulina , Borek Zuzanna , Kalemba Sylwia , Kuźniar Julia , Litwin Anna , Olczyk Monika , Pancerz Agnieszka 
Published: February 2025

Artykuł omawia metodę oczyszczania warstwy malarskiej i usuwania nawarstwień za pomocą środków wodnych według systemu Modular Cleaning Program. W pierwszej części przedstawiono podstawowe zagadnienia teoretyczne, sposób pracy z programem i jego możliwe zastosowania. Druga część opisuje dotychczasową praktykę stosowania MCP na Wydziale Konserwacji i Restauracji Dzieł Sztuki ASP w Krakowie na przykładzie sześciu realizacji konserwatorskich prowadzonych w ramach dyplomów magisterskich w latach 2022/2023: z zakresu malarstwa sztalugowego na drewnie i płótnie, rzeźby drewnianej i kamiennej oraz sztuki współczesnej. W każdym z nich określono rodzaje oczyszczanej warstwy malarskiej i usuwanych nawarstwień, zaprezentowano szereg wykonanych prób i rezultaty oczyszczania. W podsumowaniu zebrano wnioski dotyczące stosowania roztworów wodnych i emulsji z MCP.
Theodor Mommsen and the collegia funeraticia
Authors: Wojciechowski Przemysław 
Published: February 2025

In 1843, Theodor Mommsen completed his legal studies at the University of Kiel; in the same year, his dissertation De collegiis et sodaliciis Romanorum appeared in print. This publication, which was small in terms of volume, not only opened the door to an illustrious academic career for its author, but also had an enormous impact on the course of scholarly discussion on Roman colleges. One of the basic concepts used in this discussion is the 'funeral colleges' created by Mommsen. The main purpose of this article is to show that we are dealing with an anachronism in this case. Mommsen's proposed concept of 'funeral colleges' found very fertile ground in Germany at the time ('bürgerliche Vereinsbewegung' and Bismarck's social reforms), but it is not substantiated by the source material. None of the known Roman colleges was a 'funeral college' in the sense in which the term was used by Mommsen and his scholarly heirs. The fact that, for many colleges, helping to organise the burial of a deceased member was an important sphere of their activity does not make them 'funeral colleges'.

W 1843 roku Theodor Mommsen skończył studia prawnicze na uniwersytecie w Kilonii; w tym samym roku ukazała się drukiem jego rozprawa „De collegiis et sodaliciis Romanorum”. Ta niewielka pod względem objętości publikacja nie tylko otworzyła drzwi do wspaniałej kariery akademickiej jej autora, lecz wywarła także ogromny wpływ na przebieg dyskusji naukowej na temat rzymskiego korporacjonizmu. Jednym z podstawowych pojęć używanych w tej dyskusji są wykreowane przez Mommsena „kolegia pogrzebowe”. Głównym celem tego artykułu jest wykazanie, że mamy w tym przypadku do czynienia z anachronizmem. Zaproponowana przez Mommsena koncepcja „kolegiów pogrzebowych” trafiła na bardzo podatny grunt w ówczesnych Niemczech („bürgerliche Vereinsbewegung” i reformy społeczne Bismarcka), nie ma jednak uzasadnienia w materiale źródłowym. Żadne ze znanych rzymskich kolegiów nie było „kolegium pogrzebowym” w tym znaczeniu, w jakim tego terminu używał Mommsen i jego naukowi spadkobiercy. Fakt, że dla wielu kolegiów pomoc w zakresie organizacji pochówku zmarłego członka była ważną sferą ich aktywności, nie czyni z nich „kolegiów pogrzebowych”.
Comparison between patients who have undergone cancer surgery based on MST value: a retrospective study.
Authors: ADRIAN Wina , AS'AD Suryani , SYAUKI A Yasmin , PRIHANTONO · , TASLIM Nurpudji A. , ASHARI Nur 
Published: February 2025

Abstract
Introduction: Malnutrition is a prevalent concern in oncologic surgery patients, often exacerbated by the effects of cancer and its treatments. Malnutrition is associated with poor clinical outcomes, including higher mortality rates, longer hospital stays, and increased complications. The Malnutrition Screening Tool (MST) is a valuable method for identifying malnutrition risk at hospital admission. This study aims to assess the prevalence of malnutrition using the MST and evaluate its prognostic value in relation to clinical outcomes, such as length of stay (LOS), inflammatory markers, and mortality in oncologic surgery patients.
Methods: A retrospective cohort study was conducted at Dr. Wahidin Sudirohusodo Hospital in Makassar, Indonesia, from January 2022 to January 2024. Nutritional status was assessed using the MST, and key clinical outcomes—LOS, inflammatory markers (Neutrophil-to-Lymphocyte Ratio [NLR]), serum albumin, total lymphocyte count (TLC), and Prognostic Nutritional Index (PNI)—were analyzed. Statistical comparisons were performed using chi-square tests and t-tests, with statistical significance set at p < 0.05.
Results: Among the 284 patients, 33.8% were classified as malnourished (MST ≥2). Patients with higher MST scores had significantly worse clinical outcomes, including higher mortality (33.3% vs. 12.3% for MST <2, p < 0.001). Malnourished patients exhibited poorer inflammatory and nutritional markers, with higher NLR (6.13 vs. 4.68, p = 0.05), lower albumin (3.0 g/dL vs. 3.3 g/dL, p = 0.004), and lower PNI (36.4 vs. 41.8, p < 0.001). No significant difference was found in LOS between the two groups (median 10 days vs. 9 days, p = 0.732).
Conclusion: Malnutrition, as identified by the MST, is strongly associated with increased mortality and worsened inflammatory and nutritional markers in oncologic surgery patients. These findings underscore the need for routine nutritional screening and timely interventions to improve clinical outcomes in this high-risk population.
Relación de los marcadores bioquímicos con factores sociodemográficos en pacientes con neoplasias hematológicas. Análisis de correspondencias múltiples.
Authors: ARMIJO VALVERDE Kevin , MENECES ZAPATIER Ketty Elena , MORALES CALUÑA Edgar Rolando , VILLAFUERTE LLANTUY Karla Estefanía 
Published: February 2025

Introducción: Las neoplasias hematológicas son un grupo de enfermedades cancerígenas que pueden involucrar sistemas y órganos, estas patologías representan diferentes vías de tratamiento y mediciones de pronóstico, como son valores bioquímicos y datos demográficos.
Objetivos: Investigar la relación entre los marcadores bioquímicos y los factores sociodemográficos en pacientes con neoplasias hematológicas.
Materiales y Métodos: Estudio transversal retrospectivo, se obtuvo acceso mediante la recolección y revisión de datos de las historias clínicas de los pacientes hospitalizados en el área de hematología, la muestra fue de 62 pacientes. Se utilizó el modelo de análisis de correspondencia múltiple.
Resultados: Las edades de los participantes oscilaban entre 25 y 44 años (64,52%); además, el 67,64% eran de sexo masculino y el 30,65% presento una ganancia de peso. Los hombres (29,03%) tienen una mayor tendencia a ganar peso en comparación de las mujeres (1,61%). Por otro lado, se observaron que los valores de albúmina, fósforo y proteínas totales se relacionan con el sexo y la variación del peso corporal.
Conclusiones: Las variables sexo, albúmina, fósforo y proteínas totales están asociadas con la variación de peso en los pacientes con neoplasias hematológicas.
Multi nutrient functional biscuits “Tumiz” improve nutritional status and growth of children; A clinical trial in malnourished rats.
Authors: Nadimin Nadimin , Asikin Hijrah , NYIN Ang Yeow , THIEN Lee Shoo , ABIDIN Azrina Zainal 
Published: February 2025

Background: The main cause of malnutrition in Indonesia is insufficient nutrient intake, necessitating efforts to supplement nutrients through supplementary feeding. Conversely, Indonesia possesses a variety of local food ingredients that remain underutilized, thus requiring processing to enrich the nutrient content of snacks for combating malnutrition.malnourished Wistar rats.
Methods: Employing a randomized control group pretest-posttest design, male Wistar rats divided into four groups, each comprising 6 samples. These groups included K1: normal rats fed standard food, K-2: malnourished rats given biscuits from the Ministry of Health program, K-3: malnourished rats fed normal food, and K-4: malnourished rats given Tumiz biscuits. The intervention spanned eight weeks, during which body weight, body length, albumin, IGF-1, and MDA levels were measured before and after the intervention.
Results: Significant increases in body weight were observed between pretest-posttest in all groups. The greatest increase in body weight over two months was found in group K4. The albumin levels increased in the rats, there was no statistically significant difference in albumin levels before and after the intervention acrossall groups: K1 (p=0.336), K2 (p=0.297), K3 (p=0.191), and K4 (p=0.466). All intervention groups experienced a significant increase in body length (p<0.05), including groups K1 (p<0.001), K2 (p=0.003), K3 (p<0.001), and K4 (p<0.001). The increase in body length of group K4 did not differ from group K1. IGF-1 levels of Wistar rats significantly increased in group K4 (p=0.006) and group K2 (p=0.026), while groups K1 and K3 experienced a decrease in IGF-1 levels. There was no difference in MDA levels before and after the intervention across all groups.
Conclusion: Tumiz biscuits can increase body weight, body length, and IGF-1 levels but have not been able to increase albumin levels in malnourished Wistar rats. Tumiz biscuits did not reduce MDA levels in malnourished Wistar rats.
Efecto del programa de estabilización nutricional “ESNUT” en IMC y composición corporal de menores de ocho años con desayuno escolar.
Authors: Olvera-Castillo Ma. del Carmen , Gallegos-Martinez Josefina , Reyes-Hernández Jaime 
Published: February 2025

Introducción. En San Luis Potosí incrementó el peso bajo (PB) (2.2% a 5.9%), coexistiendo con sobrepeso (SP) (18.1%) y obesidad (OB) (17.1%). La malnutrición modifica el crecimiento y composición corporal de los niños, la prevención incluye programas de alimentación escolar.
Objetivo. Evaluar el efecto del programa de estabilización nutricional "ESNUT", en el estado nutricional y composición corporal de los niños adscritos al programa de desayunos escolares fríos.
Métodos. Diseño intervención con seguimiento, con grupo experimental en dos escuelas de preescolar y primero y segundo grado de dos escuelas primarias públicas ubicadas en área suburbana. Población: La población se distribuyó en 148 mujeres (50.6%) y 144 hombres (49.3%). La edad estaba entre 69 y 75 meses, Los grupos experimental (GE=153) y control (GC=139) se conformaron por asignación aleatoria. Variables: Independiente. Programa de estabilización nutricional “ESNUT”. Dependientes. Talla, peso, índice de masa corporal (IMC), peso/edad (P/E), talla/edad (T/E), peso/talla (P/T), masa muscular (% MM) y masa grasa (% MG). Instrumentos: Bioimpedanciómetro InBody 230; Estadímetro Seca 274. Análisis: Prueba t-student para muestras independientes y para muestras relacionadas (95% CI; p ≤ 0.05); poder estadístico (0.80). ANOVA de una vía, ETA2 (post-hoc) y tamaño del efecto. Apoyado en SSPS Versión 21. Ética: Fundamentos en principios éticos para investigación médica en seres humanos y en especial en niños, contándose con el consentimiento informado firmado por los padres. Aprobación por un Comité de Biética.
Resultados. Estado nutricional normal〜50%. En evaluación seis (EV6) > %MM niños versus niñas; >%MG en niñas versus niños, con un tamaño de efecto pequeño. El índice de obesidad (OB) se redujo y migró hacia sobrepeso (SP).
Conclusiones. Para incremento de % MM y reducción de OB favoreció la intervención. Se constata que la educación sobre alimentación saludable es recomendable.
A constitucionalidade no âmbito do pagamento por serviços ambientais(PSA)
Authors: Dos Santos Nascimento de Salles Andréia , De Salles João Bosco 
Published: February 2025

Neste ano foi sancionada a Lei n° 14.119 que instituiu no Brasil a Política Nacional de Pagamento por Serviços Ambientais (PSA). O PSA visa estimular a recuperação e a manutenção do meio ambiente, por meio de transferências financeiras, vantagens tributárias ou outros tipos de compensação ao protetor/recebedor por ações que resultem no incremento ou manutenção de serviços ecossistêmicos. A implantação de PSA é um eficiente instrumento de promoção do desenvolvimento social, ambiental, econômico e cultural de populações rurais e urbanas. O presente estudo visa avaliar os aspectos legais e constitucionais da participação do proprietário de terras no programa de PSA, em casos nos quais o objeto do programa seja a recuperação e/ou a preservação de áreas da propriedade cuja proteção ambiental caracteriza-se como sua responsabilidade legal. Como resultados de levantamentos bibliográficos observamos que o Novo Código Florestal, Lei n° 12.651/12, confere autorização para que o Poder Público financie de maneira ampla os programas de PSA, sem qualquer exceção. Observamos também que vários programas públicos têm financiado o PSA a proprietários de terras para fazerem muitas vezes o que é o seu mero dever legal de preservação ambiental. Pesquisas feitas sobre o tema em sites de busca como o Google, além dos sites do Superior Tribunal de Justiça (STJ) e do Supremo Tribunal Federal (STF), demonstraram a inexistência de jurisprudência sobre o assunto. Portanto, concluímos que o assunto carece ainda de melhor discussão, entendimento e interpretação legal e constitucional, de maneira a permitir o fluxo normal dos programas de PSA, que são imprescindíveis para a recuperação e a manutenção da saúde ambiental.