bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of thriving in mental health among people with intellectual and developmental disabilities during the COVID‐19 pandemic in Canada
Authors: Sellitto Teresa , Fraser‐Thomas Jessica , Bassett‐Gunter Rebecca L. , Lee Vivian , Lunsky Yona , Balogh Robert , Weiss Jonathan A. 
Published: November 2023

AbstractBackgroundThe COVID‐19 pandemic has had a negative impact on the mental health of people with intellectual and developmental disabilities. Numerous pandemic‐related stressors experienced by people with intellectual and developmental disabilities may have impacted their ability to thrive, which has been linked to mental health outcomes. The current study examined the associations among COVID‐19 stressors, thriving, and mental health problems among youth and adults with intellectual and developmental disabilities.MethodCaregivers of 159 people with intellectual and developmental disabilities between 12 and 35 years of age from Canada completed an online questionnaire.ResultsA mediation analysis revealed that COVID‐19 stressors were positively associated with mental health problems, and that thriving partially mediated this association.ConclusionOur findings suggest that experiences of thriving may be an important target for mental health support for people with intellectual and developmental disabilities.
Whole‐exome sequencing analysis of patent ductus arteriosus in a Japanese macaque (Macaca fuscata)
Authors: Jang Young‐Jin , Park Byung‐Yong , Tae Hyun‐Jin , Sim Jeoungha , Ahn Dongchoon 
Published: November 2023

AbstractWe performed whole‐exome sequencing using a human exome capture kit to analyze the potential genetic factors related to patent ductus arteriosus in Japanese macaques. Compared with the reference sequences of other primates, we identified potential missense variants in five genes: ADAM15, AZGP1, CSPG4, TNFRSF13B, and EPOR.
Synergistic effects of immune checkpoints and checkpoint inhibitors in inflammatory neuropathies: Implications and mechanisms
Authors: Sarkar Aritrani , Nagappa Madhu , Dey Saikat , Mondal Sandipan , Babu Gopika Suresh , Choudhury Saptamita Pal , Akhil Pokala , Debnath Monojit 
Published: November 2023

AbstractImmune checkpoint molecules play pivotal roles in the regulation of immune homeostasis. Disruption of the immune checkpoints causes autoimmune/inflammatory as well as malignant disorders. Over the past few years, the immune checkpoint molecules with inhibitory function emerged as potential therapeutic targets in oncological conditions. The inhibition of the function of these molecules by using immune checkpoint inhibitors (ICIs) has brought paradigmatic changes in cancer therapy due to their remarkable clinical benefits, not only in improving the quality of life but also in prolonging the survival time of cancer patients. Unfortunately, the ICIs soon turned out to be a “double‐edged sword” as the use of ICIs caused multiple immune‐related adverse effects (irAEs). The development of inflammatory neuropathies such as Guillain–Barré syndrome (GBS) and Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) as the secondary effects of immunotherapy appeared very challenging as these conditions result in significant and often permanent disability. The underlying mechanism(s) through which ICIs trigger inflammatory neuropathies are currently not known. Compelling evidence suggests autoimmune reaction and/or inflammation as the independent risk mechanism of inflammatory neuropathies. There is a lack of understanding as to whether prior exposure to the risk factors of inflammatory neuropathies, the presence of germline genetic variants in immune function‐related genes, genetic variations within immune checkpoint molecules, the existence of autoantibodies, and activated/memory T cells act as determining factors for ICI‐induced inflammatory neuropathies. Herein, we highlight the available pieces of evidence, discuss the mechanistic basis, and propose a few testable hypotheses on inflammatory neuropathies as irAEs of immunotherapy.
Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients
Authors: van Doormaal Perry T. C. , Thomas Simone , Ajroud‐Driss Senda , Cole Robert N. , DeVine Lauren R. , Dimachkie Mazen M. , Geisler Stefanie , Freeman Roy , Simpson David M. , Singleton J. Robinson , Smith A. Gordon , Stino Amro ,   PNRR Study Group, Höke Ahmet 
Published: November 2023

AbstractBackground and AimsWhy only half of the idiopathic peripheral neuropathy (IPN) patients develop neuropathic pain remains unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain.MethodsWe conducted unbiased mass‐spectrometry proteomics analysis on blood plasma from 31 IPN patients with severe neuropathic pain and 29 IPN patients with no pain, to investigate protein biomarkers and protein–protein interactions associated with neuropathic pain. Univariate modeling was done with linear mixed modeling (LMM) and corrected for multiple testing. Multivariate modeling was performed using elastic net analysis and validated with internal cross‐validation and bootstrapping.ResultsIn the univariate analysis, 73 proteins showed a p‐value <.05 and 12 proteins showed a p‐value <.01. None were significant after Benjamini–Hochberg adjustment for multiple testing. Elastic net analysis created a model containing 12 proteins with reasonable discriminatory power to differentiate between painful and painless IPN (false‐negative rate 0.10, false‐positive rate 0.18, and an area under the curve 0.75). Eight of these 12 proteins were clustered into one interaction network, significantly enriched for the complement and coagulation pathway (Benjamini–Hochberg adjusted p‐value = .0057), with complement component 3 (C3) as the central node. Bootstrap validation identified insulin‐like growth factor‐binding protein 2 (IGFBP2), complement factor H‐related protein 4 (CFHR4), and ferritin light chain (FTL), as the most discriminatory proteins of the original 12 identified.InterpretationThis proteomics analysis suggests a role for the complement system in neuropathic pain in IPN.
Evaluation of American College of Radiology Ovarian‐Adnexal Reporting and Data System ultrasound to predict malignancy risk in adnexal lesions
Authors: Li Ya , Shao Guangrui , Wu Mei , Zhang Feixue , Zhang Yuqing , Shao Chunchun 
Published: November 2023

AbstractAimsTo validate the diagnostic performance of Ovarian‐Adnexal Reporting and Data System (O‐RADS) ultrasound for preoperative adnexal lesions in an external center. The secondary aim was to evaluate the performance of a strategy test including O‐RADS ultrasound evaluation and subjective assessment of higher malignant risk lesions.MethodsOne hundred thirty patients with 158 ovarian‐adnexal lesions were enrolled in the study. Each lesion was assigned an O‐RADS score after real‐time ultrasound examination by one experienced radiologist. A second subjective assessment by an expert was performed for O‐RADS 4 and O‐RADS 5 lesions. The histopathological diagnosis was used as the reference standard.ResultsA total of 126 benign and 32 malignant adnexal masses were included in the study. The area under the receiver operating characteristic curve of O‐RADS ultrasound was 0.950, with a cutoff value > O‐RADS 3. The sensitivity, specificity, and negative and positive predictive values were 100% (95% confidence interval [CI], 0.867–1), 83.3% (95% CI, 0.754–0.892), 60.4% (95% CI, 0.460–0.732), and 100% (95% CI, 0.956–1), respectively. For the strategy test, the sensitivity, specificity, negative and positive predictive values were 100% (95% CI, 0.867–1), 92.1% (95% CI, 0.855–0.959), 76.2% (95% CI, 0.602–0.874), and 100% (95% CI, 0.960–1), respectively. In comparison with O‐RADS ultrasound, the specificity and negative predictive value of the strategy test were slightly higher (p < 0.05).ConclusionsGood diagnostic performance of the O‐RADS ultrasound in adnexal lesions can be achieved by experienced radiologists in clinical practice. A second subjective assessment of sonographic findings can be applied to O‐RADS 4 and 5 lesions.
Dynamic Capabilities and MNE Global Strategy: A Systematic Literature Review‐Based Novel Conceptual Framework
Authors: Pitelis Christos N. , Teece David J. , Yang Hongyi 
Published: November 2023

AbstractGlobal strategy cannot be fully understood without consideration of dynamic capabilities (DCs). This is because the three key constituents of DCs – the sensing and seizing of opportunities and the reconfiguration of the resource base – are essential preconditions for strategy development, within nations and cross‐border. We investigate the aspects of DCs that are most suitable for global strategy and those that need to be revisited and developed. We discuss theory and evidence on DCs and global strategy, present a systematic literature review, compare theory and evidence, and identify gaps between the two as well as opportunities to align them more closely and to develop both. To help guide future research, we develop a novel conceptual framework and provide suggestions for more theory‐congruent empirical research.
Diaporthe melongenae sp. nov, a new fungal species causing leaf blight in eggplant
Authors: Aumentado Herbert Dustin , Balendres Mark Angelo 
Published: November 2023

AbstractEggplant is a vegetable crop of the Solanaceae family. In November 2021, leaf blights of eggplant were observed from an eggplant field with an approximate disease incidence of 10%–30% in Cavite, Philippines. The infected leaves had typical symptoms of Phomopsis blight disease. Two fungal isolates were obtained, and morphological characteristics resemble those of a Diaporthe species. Based on the combined multi‐gene phylogenetic analysis, Diaporthe melongenae sp. nov. formed a separate clade from closely related species: D. guangdongensis, D. melonis and D. moriniae with high bootstrap support values of 99/1.0 ML/PP. Moreover, the morphological characteristics of D. melongenae have differences from the closely related species. D. melongenae differs by having a slightly smaller average alpha conidial size than D. guangdongensis and absence of beta conidia. Diaporthe melonis is distinct from D. melongenae by having slightly constricted middle alpha conidia. Together, based on morphology, multi‐locus phylogeny, GCPSRA and ecology (lifestyle, host and pathogenicity) herein we introduce D. melongenae as a novel species. Furthermore, this study presented the current phylogenetic tree of D. sojae species complex based on accepted Diaporthe species.
The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke
Authors: Zhang Xinmu , Peng Bin , Zhang Shenqi , Wang Jian , Yuan Xiong , Peled Sharon , Chen Wu , Ding Jinyin , Li Wei , Zhang Andrew , Wu Qiaofeng , Stavrovskaya Irina G. , Luo Chengliang , Sinha Bharati , Tu Yanyang , Yuan Xiaojing , Li Mingchang , Liu Shuqing , Fu Jianfang , Aziz‐Sultan Ali , Kristal Bruce S. , Alterovitz Gil , Du Rose , Zhou Shuanhu , Wang Xin 
Published: November 2023

AbstractStroke is the leading cause of death and disability worldwide. Novel and effective therapies for ischemic stroke are urgently needed. Here, we report that melatonin receptor 1A (MT1) agonist ramelteon is a neuroprotective drug candidate as demonstrated by comprehensive experimental models of ischemic stroke, including a middle cerebral artery occlusion (MCAO) mouse model of cerebral ischemia in vivo, organotypic hippocampal slice cultures ex vivo, and cultured neurons in vitro; the neuroprotective effects of ramelteon are diminished in MT1‐knockout (KO) mice and MT1‐KO cultured neurons. For the first time, we report that the MT1 receptor is significantly depleted in the brain of MCAO mice, and ramelteon treatment significantly recovers the brain MT1 losses in MCAO mice, which is further explained by the Connectivity Map L1000 bioinformatic analysis that shows gene‐expression signatures of MCAO mice are negatively connected to melatonin receptor agonist like Ramelteon. We demonstrate that ramelteon improves the cerebral blood flow signals in ischemic stroke that is potentially mediated, at least, partly by mechanisms of activating endothelial nitric oxide synthase. Our results also show that the neuroprotection of ramelteon counteracts reactive oxygen species‐induced oxidative stress and activates the nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 pathway. Ramelteon inhibits the mitochondrial and autophagic death pathways in MCAO mice and cultured neurons, consistent with gene set enrichment analysis from a bioinformatics perspective angle. Our data suggest that Ramelteon is a potential neuroprotective drug candidate, and MT1 is the neuroprotective target for ischemic stroke, which provides new insights into stroke therapy. MT1‐KO mice and cultured neurons may provide animal and cellular models of accelerated ischemic damage and neuronal cell death.
Voriconazole plus flucytosine is not superior to amphotericin B deoxycholate plus flucytosine as an induction regimen for cryptococcal meningitis treatment
Authors: Zhao Handan , Lu Yanqiu , Li Shan , Qin Jiangying , Xu Miaomiao , Ye Hui , Yang Zongxing , Rao Jianfeng , Chen Guochun , Su Feifei , Hu Zhiliang , Xu Lijun 
Published: November 2023

AbstractBackgroundThe efficacy and side effects of voriconazole plus 5‐flucytosine (Vori + 5‐FC) versus amphotericin B deoxycholate plus 5‐flucytosine (AmBd + 5‐FC) as an induction treatment for cryptococcal meningitis are unknown.MethodsForty‐seven patients treated with Vori + 5‐FC and 92 patients treated with AmBd + 5‐FC were included in the current study after propensity score matching (PSM) at a ratio of 1:2. Two‐week laboratory test results and 90‐day mortality were compared between the two groups.ResultsAfter 2 weeks of induction treatment, the CSF Cryptococcus sterile culture rate was 57.1% in the Vori + 5‐FC group and 76.5% in the AmBd + 5‐FC group (p = .026). No difference was found in the normalization of CSF indicators (glucose, total protein, intracranial pressure and India ink sterile rate) between the two groups. Both the Vori + 5FC regimen and AmBd + 5‐FC regimen obviously decreased haemoglobin concentrations, platelet counts and serum potassium levels (all p ≤ .010). Notably, the Vori + 5FC regimen did not influence serum creatinine levels (p = .263), while AmBd + 5FC increased serum creatinine levels (p = .019) after 2‐week induction treatment. The Vori + 5‐FC group and AmBd + 5‐FC group had similar 90‐day cumulative survival rates (89.9% vs. 87.8%, p = .926).ConclusionThe Vori + 5‐FC regimen was associated with low 2‐week CSF sterile culture and was not superior to AmBd + 5‐FC as induction therapy in terms of the 90‐day cumulative survival rate of CM patients.
A machine learning–based generalized approach for predicting unauthorized immigration flow considering dynamic border security nexus
Authors: Aziz Ridwan Al , Ahmed Tanvir , Zhuang Jun 
Published: November 2023

AbstractUnauthorized immigration has been a long‐standing and contentious challenge for developed and developing countries. Numerous continually evolving push and pull factors across international borders, such as economy, employment, population density, unrest, corruption, and climate have driven this migration. Large‐scale pandemics such as COVID‐19, causing further instability in countries' financial well‐being, can initiate or alter emigration flow from different countries. In light of such a complex confluence of factors, climate change, and demographic shifts in migrant communities, it is high time to shift toward machine learning–reinforced generalized approaches from the traditional parametric approaches based on migrant community–specific localized surveys. To our best knowledge, no literature has explored the nonparametric approach and developed a comprehensive database independent of localized surveys to analyze unauthorized migration. This article fills this gap by deploying nine nonparametric machine learning algorithms for predicting unauthorized immigration flow considering the dynamic border security nexus. This framework considers the Seasonal Autoregressive Integrated Moving Average model as the null model. The proposed novel framework removes the dependency on localized survey‐based studies and provides a more cost‐effective, faster, and big data–friendly approach. This study finds the Bayesian Additive Regression Tree model as the best predictive model.
The ‘European City’ at the Crossroads: Four Analytical Elements for Understanding Convergence and Differentiation
Authors: Kazepov Yuri , Ahn Byeongsun , Cucca Roberta 
Published: November 2023

AbstractThis theoretical contribution explores the use of four analytical elements to understand European cities' commonalities and distinctive characteristics in the face of the challenges presented by structural global changes and supra‐national governance mechanisms: sovereignty, policy, politics, context. The article shows how institutional and contextual opportunities mediate globalization's repercussions to varying degrees at the urban level, according to national and regional dynamics and institutional frameworks as well as urban governance structures. Additionally, the article argues that the local policy capacity of cities and their ability to innovate and deal with new social challenges are shaped by the interplay among the four specific elements mentioned before.
In vitro quality parameters of whole blood‐derived platelets pooled using two different platelet pooling sets and stored up to 7 days are similar
Authors: Vandenbroeke Tania , Gloor Christina , Wingfield Tyler , Leite Caroline , Carr Kathlynn , Turner Chris , Ngamsuntikul Samantha , Sutor Laurie , Compton Frances , Nestheide Shawnagay , Rugg Neeta , Cancelas Jose A. , Dumont Larry J. 
Published: November 2023

AbstractBackgroundIncreasing the number of collections of whole blood‐derived platelets (WBDP) and lengthening the allowable storage time may alleviate platelet (PLT) shortages. There is a need for new PLT pooling sets that can provide acceptable quality on Day 7 of storage.Study Design and MethodsThis pool‐and‐split study compared WBDP prepared using the platelet‐rich plasma method with the novel IMUGARD WB PLT pooling set and a control pooling set. After pooling and filtration, PLT products were tested on Days 1, 5, and 7. Large volume delayed sampling (LVDS) cultures were taken on Day 2.ResultsThe median postfiltration residual white blood cell (rWBC) content was 0.18 million per product (maximum 1.26 million; n = 69) with mean PLT recovery of 88.5 ± 2.8% for the new set and median 0.23 million (maximum 1.83 million) rWBC with 87.5 ± 2.5% recovery for the control. Day 5 mean pH22°C were 7.18 ± 0.12 and 7.13 ± 0.10 for the new and control set, respectively. Day 5 in vitro quality parameters were within 20% between the two pooling sets. The new set Day 7 pH22°C was acceptable (7.07 ± 0.17, 100% ≥ 6.3), and most parameters were within 20% of Day 5 values.ConclusionWBDP quality for the new pooling set is acceptable across a battery of in vitro tests when stored up to 7 days and meets FDA regulatory criteria. The quality parameters were similar between the new pooling set and the control set on Day 5. This new set is compatible with LVDS.
Prime tuples and Siegel zeros
Authors: Wright Thomas 
Published: November 2023

AbstractUnder the assumption of infinitely many Siegel zeroes with for a sufficiently large value of , we prove that there exist infinitely many ‐tuples of primes that are apart. This ‘improves’ (in some sense) on the bounds of Maynard–Tao, Baker–Irving, and Polymath 8b, who found bounds of unconditionally and assuming the Elliott–Halberstam conjecture; it also generalizes a 1983 result of Heath–Brown that states that infinitely many Siegel zeroes would imply infinitely many twin primes. Under this assumption of Siegel zeroes, we also improve the upper bounds for the gaps between prime triples, quadruples, quintuples, and sextuples beyond the bounds found via Elliott–Halberstam.
A new approach to twisted homological stability with applications to congruence subgroups
Authors: Putman Andrew 
Published: November 2023

AbstractWe introduce a new method for proving twisted homological stability, and use it to prove such results for symmetric groups and general linear groups. In addition to sometimes slightly improving the stable range given by the traditional method (due to Dwyer), it is easier to adapt to nonstandard situations. As an illustration of this, we generalize to of many rings a theorem of Borel that says that passing from of a number ring to a finite‐index subgroup does not change the rational cohomology. Charney proved this generalization for trivial coefficients, and we extend it to twisted coefficients.
Passive Design Strategies in Focus: Implications of Climate Change on New Buildings and Renovations
Authors: Ganem-Karlen Carolina , Barea-Paci Gustavo Javier 
Published: November 2023

Abstract
Climate change is happening, and there is a general consensus that measures to drastically reduce emissions must be taken. Nevertheless, its implications on new buildings and renovations are not fully understood yet. Bioclimatic building design is based on the knowledge of passive design strategies potential for a location. However, traditionally used passive strategies may no longer be the correct design approach in the future. A methodological contribution for the assessment of the influence of climate change on passive building strategies in temperate climates is presented. Based on the top priority Intergovernmental Panel on Climate Change scenarios of the 6th assessment report (AR6) the shared socio-economic pathways (SSP) and their equivalences with the prior representative concentration pathways (RCP), the effects of climate change on different cooling and heating strategies are examined for a continental temperate-cold desert climate with significant daily and annual variation. The results are integrated directly into a selected case study with the intention of exemplifying a concrete application. The findings of this study showed that the shading season is expanding even toward the transitional months, such as April and October. Future climate-adapted buildings in temperate climatic zones will have to confront overheating. Moreover, in the particular studied case, present and future total energy requirements seem similar and variations are perceived as low between scenarios. The main discussion focuses on the type of energy required that will turn from natural gas (net to primary energy conversion factor = 1.25) to electricity (net to primary energy conversion factor = 3.30).