bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible mechanisms mitigating reproductive interference supposed between Xylena fumosa (Butler) and X. formosa (Butler) (Lepidoptera: Noctuidae: Xyleninae), both by‐captured in a commercial pheromone trap for Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae: Heliothinae)
Authors: Kohno Katsuyuki , Iida Hiroyuki 
Published: February 2024

AbstractAs differences in sex pheromones usually act as a barrier against interspecific mating, the fact that the closely related moths Xylena fumosa (Butler) and X. formosa (Butler) (Lepidoptera: Noctuidae: Xyleninae) are commonly attracted to the sex pheromone lure for Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae: Heliothinae) seems unlikely, suggesting that some mechanisms exist between them to mitigate a potential reproductive interference in pheromone communications. Thus, we examined the overlaps in ecological niches of the two species, and their attractiveness to commercial pheromone lures for other moths, through pheromone trap surveys and published reports. Long‐term field surveys using traps baited with five to six types of artificial sex pheromone lures including those designed for H. armigera, and information in published works revealed that there was a nonnegligible overlap between the two species in terms of seasonal timing of captures, geographic habitats and host plants. These factors, therefore, did not appear to provide conclusive evidence mitigating reproductive interference. However, there was a slight but significant difference between them in the trends of attraction to different artificial pheromone lures; X. formosa was attracted albeit in a small number to the lures for Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae), whereas X. fumosa was only attracted to those for H. armigera. This suggests that differences in pheromone composition, rather than differences in temporal and spatial distributions, between the two species could play a more significant role in premating reproductive isolations.
Interictal EEG source connectivity to localize the epileptogenic zone in patients with drug‐resistant epilepsy: A machine learning approach
Authors: Ntolkeras Georgios , Makaram Navaneethakrishna , Bernabei Matteo , De La Vega Aime Cristina , Bolton Jeffrey , Madsen Joseph R. , Stone Scellig S. D. , Pearl Phillip L. , Papadelis Christos , Grant Ellen P. , Tamilia Eleonora 
Published: February 2024

AbstractObjectiveTo deconstruct the epileptogenic networks of patients with drug‐resistant epilepsy (DRE) using source functional connectivity (FC) analysis; unveil the FC biomarkers of the epileptogenic zone (EZ); and develop machine learning (ML) models to estimate the EZ using brief interictal electroencephalography (EEG) data.MethodsWe analyzed scalp EEG from 50 patients with DRE who had surgery. We reconstructed the activity (electrical source imaging [ESI]) of virtual sensors (VSs) across the whole cortex and computed FC separately for epileptiform and non‐epileptiform EEG epochs (with or without spikes). In patients with good outcome (Engel 1a), four cortical regions were defined: EZ (resection) and three non‐epileptogenic zones (NEZs) in the same and opposite hemispheres. Region‐specific FC features in six frequency bands and three spatial ranges (long, short, inner) were compared between regions (Wilcoxon sign‐rank). We developed ML classifiers to identify the VSs in the EZ using VS‐specific FC features. Cross‐validation was performed using good outcome data. Performance was compared with poor outcomes and interictal spike localization.ResultsFC differed between EZ and NEZs (p < .05) during non‐epileptiform and epileptiform epochs, showing higher FC in the EZ than its homotopic contralateral NEZ. During epileptiform epochs, the NEZ in the epileptogenic hemisphere showed higher FC than its contralateral NEZ. In good outcome patients, the ML classifiers reached 75% accuracy to the resection (91% sensitivity; 74% specificity; distance from EZ: 38 mm) using epileptiform epochs (gamma and beta frequency bands) and 62% accuracy using broadband non‐epileptiform epochs, both outperforming spike localization (accuracy = 47%; p < .05; distance from EZ: 57 mm). Lower performance was seen in poor outcomes.SignificanceWe present an FC approach to extract EZ biomarkers from brief EEG data. Increased FC in various frequencies characterized the EZ during epileptiform and non‐epileptiform epochs. FC‐based ML models identified the resection better in good than poor outcome patients, demonstrating their potential for presurgical use in pediatric DRE.
Reimagining Disabled Futurities: Of Personhood, Communication, and Intersubjectivity Sensory Futures: Deafness and Cochlear Implant Infrastructures in IndiaMichele IlanaFriedner, Minnesota, MN: University of Minnesota Press. 2022. ix+288 pp.Unraveling: Remaking Personhood in a Neurodiverse AgeMatthew J.Wolf‐Meyer, Minnesota, MN: University of Minnesota Press. 2020. xiii+316 pp.
Authors: Choudhary Priyasha , Ranganathan Shubha 
Published: February 2024

AbstractThis book review essay tries to bring together two extremely pivotal books to understand how we can reimagine dominant modes of communication and how debunking the normative ideas surrounding it helps us to cognize personhood and intersubjectivity better. Michele Friedner's ‘Sensory Futures’ and Wolf‐Meyer's ‘Unraveling’ are both critical attempts that try to understand how the sensory and neurological experiences of our body are essentially social, thereby reimagining how we understand personhood and subjectivity. Through a comprehensive analysis of both these texts individually, and in tandem with one another, this book review aims to highlight how we can find pathways to reimagine the body‐mind as inherently social and how we can try to build a more inclusive and inhabitable world that is multisensorial and multimodal.
Size‐dependence of food intake and mortality interact with temperature and seasonality to drive diversity in fish life histories
Authors: Kindsvater Holly K. , Juan‐Jordá Maria‐José , Dulvy Nicholas K. , Horswill Cat , Matthiopoulos Jason , Mangel Marc 
Published: February 2024

AbstractUnderstanding how growth and reproduction will adapt to changing environmental conditions is a fundamental question in evolutionary ecology, but predicting the responses of specific taxa is challenging. Analyses of the physiological effects of climate change upon life history evolution rarely consider alternative hypothesized mechanisms, such as size‐dependent foraging and the risk of predation, simultaneously shaping optimal growth patterns. To test for interactions between these mechanisms, we embedded a state‐dependent energetic model in an ecosystem size‐spectrum to ask whether prey availability (foraging) and risk of predation experienced by individual fish can explain observed diversity in life histories of fishes. We found that asymptotic growth emerged from size‐based foraging and reproductive and mortality patterns in the context of ecosystem food web interactions. While more productive ecosystems led to larger body sizes, the effects of temperature on metabolic costs had only small effects on size. To validate our model, we ran it for abiotic scenarios corresponding to the ecological lifestyles of three tuna species, considering environments that included seasonal variation in temperature. We successfully predicted realistic patterns of growth, reproduction, and mortality of all three tuna species. We found that individuals grew larger when environmental conditions varied seasonally, and spawning was restricted to part of the year (corresponding to their migration from temperate to tropical waters). Growing larger was advantageous because foraging and spawning opportunities were seasonally constrained. This mechanism could explain the evolution of gigantism in temperate tunas. Our approach addresses variation in food availability and individual risk as well as metabolic processes and offers a promising approach to understand fish life‐history responses to changing ocean conditions.
Investigation of healthy horse eyes microbiota and evaluation of its antimicrobial susceptibility
Authors: Fasaei Bahar Nayeri , Akbarein Hesameddin , Asadi Sepideh , Shahbazi Maryam 
Published: February 2024

SummaryBackgroundThe conjunctiva of the eye is a mucosal surface that is colonised by various bacteria. Following surgery, trauma or other underlying conditions the normal flora may cause eye infection such as conjunctival and corneal infections, or endophthalmitis.ObjectivesThis study aimed to investigate the bacterial population and antibiotic resistance of the conjunctiva in healthy horses.Study designRandom sampling of ocular samples from 20 horses during the winter (2019).MethodsSwab samples were collected from the eyes of 20 healthy horses of different breeds, ages and sexes in Tehran province, Iran. The swabs were cultured on blood agar and MacConkey agar and incubated at 37°C for 24–48 h. The isolated bacteria were characterised using cellular morphology, gram‐staining and biochemical tests. Sensitivity and resistance to 10 different antibiotics were measured using an antibiogram test.ResultsResults showed that the bacterial population consisted of various species, with Bacillus cereus being the most frequent. There were no significant differences in the frequency of isolated bacteria between sexes and age groups. There were no significant differences in the sensitivity of the bacterial flora of the eyes to colistin, ceftiofur, florfenicol, amoxicillin and ampicillin between either different age groups or different sexes of the horses (p > 0.05). However, sensitivity to enrofloxacin and ciprofloxacin was significantly correlated with the age groups of the horses (p > 0.05). A significant difference in sensitivity to trimethoprim‐sulfamethoxazole between various sexes of horses was observed.Main limitationsThe nonuniformity of the follow‐up examination, reliance on owners or caregivers of the horse for follow‐up information and lack of adequate financial resources to study more horses.ConclusionsThe study suggests that the frequency of individual bacteria comprising the bacterial flora in horses' eyes is influenced by housing and management conditions rather than age and sex.
Transposition of the levator labii superioris muscle in two standing horses
Authors: Fusco Alessandra , Stas Emanuël K. L. , Spoormakers Tijn J. P. , Veraa Stefanie , Huppes Tsjester 
Published: February 2024

SummaryOromaxillary fistulae are a complication of maxillary cheek teeth extraction in horses, particularly in cases where tooth repulsion is performed. Conservative treatment with debridement of the fistula, placement of a temporary alveolar plug and flushing of the sinus cavity can be unsuccessful. Transposition of the levator labii superioris muscle has been reported as an effective surgical option to treat chronic oromaxillary fistulae in anaesthetised horses. In this report, the surgical procedure was carried out on two standing horses, using sedation and local nerve blocks. Transposition of the levator labii superioris muscle can be safely and successfully performed in the standing sedated horse and may be considered for the management of cases with chronic refractory oromaxillary fistulae not responding to conservative treatment.
Ferrostatin 1 ameliorates UVB‐induced damage of HaCaT cells by regulating ferroptosis
Authors: Teng Yan , Tang Hui , Tao Xiaohua , Huang Youming , Fan Yibin 
Published: February 2024

AbstractFerroptosis, a type of programmed cell death, occurs when there is oxidative stress and lipid peroxides. This condition is marked by lipid peroxidation that relies on iron and the reduction of cellular defences against oxidation. To investigate the effect of UVB irradiation on ferroptosis of human keratinocytes HaCaT cells, the cells were pretreated with Ferrostatin 1 (Fer‐1, 10 μM), an ferroptosis inhibitor and then irradiated with UVB (20 mJ/cm2) for 30 min to detect related indexes of ferroptosis through MTT assay, quantitative real‐time polymerase chain reaction, flow cytometry, reactive oxygen species (ROS) assay, western blotting. Results showed that UVB significantly reduced cell activity, promoted apoptosis and ROS level, whereas Fer‐1 significantly increased cell activity, and reduced apoptosis and ROS level. In addition, UVB significantly reduced levels of ferroptosis‐related proteins and skin barrier‐related proteins, and increased levels of γ‐H2AX and iron, whereas Fer‐1 significantly increased their protein levels, and reduced levels of γ‐H2AX and iron. Conjoint analysis of transcriptomic and proteomic revealed that UVB significantly reduced the levels of TIMP metallopeptidase inhibitor 3 (TIMP3), and coagulation factor II thrombin receptor (F2R), whereas Fer‐1 significantly promoted the levels of TIMP3, and F2R. Therefore, our results indicated that Fer‐1 significantly ameliorates UVB‐induced damage of HaCaT cells by regulating the levels of TIMP3 and F2R.
Impact of 1‐year treatment with dupilumab on work productivity in Japanese patients with atopic dermatitis
Authors: Sakurai Emi , Kamata Masahiro , Uchida Hideaki , Okada Yoshiki , Suzuki Shoya , Takeshima Ryosuke , Ito Makoto , Watanabe Ayu , Mizukawa Itsumi , Egawa Shota , Chijiwa Chika , Hiura Azusa , Fukaya Saki , Hayashi Kotaro , Fukuyasu Atsuko , Tanaka Takamitsu , Ishikawa Takeko , Tada Yayoi 
Published: February 2024

AbstractAtopic dermatitis (AD) places a burden on work productivity. Recently, dupilumab was approved for AD, but its impact on work productivity in Japanese patients has not been reported. Furthermore, data on the effect of long‐term treatment with dupilumab on work productivity are limited. We investigated the work productivity and activity in Japanese patients with moderate‐to‐severe AD, utilizing the Japanese version of the Work Productivity and Activity Impairment (WPAI‐AD‐Japan) questionnaire. Furthermore, we examined the impact of dupilumab on work productivity. Adult moderate‐to‐severe AD patients treated with dupilumab for more than 12 months from March 2020 to June 2022 who filled out the WPAI‐AD‐Japan questionnaire were included. Twenty‐eight adult AD patients were analysed. Absenteeism was low (mean: 5.3%), but presenteeism, work productivity loss and activity impairment were high (36.8%, 39.7%, 48.9%, respectively). Significant positive correlations were observed between work productivity loss and visual analogue scale (VAS) score of pruritus and between activity impairment and dermatology life quality index (DLQI). Dupilumab treatment significantly reduced presenteeism, work productivity loss and activity impairment at both 6 and 12 months. The extent of their amelioration was numerically higher at 12 months than at 6 months. The reduction rates in presenteeism, work productivity loss and activity impairment were positively correlated with the reduction rates in DLQI and VAS score of pruritus at 12 months. Dupilumab improved work productivity in Japanese AD patients. Long‐term remission of pruritus and improved quality of life are important for comprehensive improvement of work productivity.
Improved minority attack detection in Intrusion Detection System using efficient feature selection algorithms
Authors: Rejimol Robinson R. R. , Anagha Madhav K. P. , Thomas Ciza 
Published: February 2024

AbstractMachine Learning and Data Mining algorithms are used extensively to enhance the performance of Intrusion Detection Systems. The number of training instances and the dimensionality of data are crucial factors affecting the performance of the model built during the training of any supervised learning algorithms. A sufficient proportion of instances having relevant features from all classes of attacks and normal traffic are considered most desirable while building the classification model that classifies the network traffic into attack and normal. This paper proposes a methodology to improve the accuracy of the model by giving importance to the relevant features that can contribute to model building. The feature selection using correlation‐based and information gain‐based techniques during training and testing contributes much to the detection of stealthier attacks and minority attacks. Then the features of the less detected attacks are identified as the second phase of the filter that is used to improve the performance. The relevant features of stealthy attacks are identified based on the correlation of corresponding features of the attack and normal data as the attacks are made stealthy mostly by making it resemble the normal traffic. Finally, the attacks that are rarely found in the training data are oversampled to improve their detection. CICIDS 2017 data set is employed as it comprises stealthier attacks generated using modern tools. NSL KDD data set is also used for evaluation to compare the proposed work with existing literature as it is used in most of the available literature. The results show superior performance with an accuracy of 99.8%, false positive rate of 0.2%, and a detection rate and 99.8%.
A new frontier in dashboard design: Evaluating an innovative meta‐modelling approach through expert insights
Authors: Vázquez‐Ingelmo Andrea , García‐Holgado Alicia , García‐Peñalvo Francisco José , Therón Roberto , Colomo‐Palacios Ricardo 
Published: February 2024

AbstractContextData visualizations and dashboards are essential in disseminating information to broad audiences. However, designing these instruments is complex due to the multitude of involved factors. Theoretical frameworks are therefore critical to guide the design and implementation of data visualizations.ObjectiveThis article presents the approach used to pinpoint key features that impact the creation of information visualizations, organize these features using meta‐modelling, and validate the final artefact through expert judgement.MethodMeta‐modelling facilitates the distillation of characteristics and functionalities critical for the development of information systems. Utilizing this method, a dashboard meta‐model was constructed in preceding research, yielding a framework of abstract components and connections to delineate specific products. This meta‐model serves as a robust tool for the automated generation of information visualizations and dashboards. Nonetheless, to confirm its quality and efficacy, it underwent a thorough quality assessment and expert evaluation to identify and address potential shortcomings.ResultsThe validation process resulted in positive ratings and constructive feedback to enhance the meta‐model's present iteration. Experts mainly highlighted the meta‐model's complexity and the clarity of certain entities, noting potential confusion for non‐experts.ConclusionsWhile the meta‐model is confirmed to be a coherent and pertinent tool, it requires additional clarifications to simplify its complexity. Addressing this, graphical interfaces have been developed to enable users to interact with the dashboard meta‐model—and to create dashboard instances—through straightforward interactions.
Anticancer effect of propranolol on diethylnitrosamine‐induced hepatocellular carcinoma rat model
Authors: Tamim Yomna M. , Nagy Ahmed A. , Abdellah Ahmed M. , Osman Ahmed H. , Ismail Amel F. M. 
Published: February 2024

AbstractBackgroundHepatocellular carcinoma (HCC) is the most widespread type of primary liver cancer. Diethylnitrosamine (DEN), a hepatotoxic hepatocarcinogenic compound, is used to induce HCC in animal models. The non‐selective β‐blocker propranolol demonstrated antiproliferative activity in many cancer types.ObjectiveThis investigation aimed to evaluate the anticancer effect of propranolol against DEN‐induced HCC in rats.MethodsThirty adult male rats were divided into the following groups: Group I (C, control), Group II (HCC); received DEN, 70 mg/kg body weight (b.wt.) once a week for 10 weeks, to induce HCC, and Group III (HCC/Prop); received DEN for 10 weeks for HCC induction, then received 20 mg/kg b.wt. propranolol, intraperitoneally for four successive weeks.ResultsHCC was developed in rats' livers and confirmed via significant liver architecture changes, significantly elevated activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), α‐fetoprotein (AFP), total‐ and direct‐bilirubin (Bil), and a decline in albumin (ALB) level in serum. HCC group demonstrated elevated levels of malondialdehyde (MDA), nitric oxide (NO), HIF‐1α, IL‐8, NF‐κB, PGE2, TGF‐β1, VEGF, and CD8, but significant decline of GSH, and IL‐10 level, with suppression of the antioxidant enzymes' activities. In addition, the gene expression of the hepatic inducible nitric oxide synthase (iNOS), and LAG‐3 were up‐regulated. Moreover, the protein expression of p‐PKC was up‐regulated, while that of PD‐1 and PD‐L1 were down‐regulated in the liver tissues of the HCC group. However, propranolol ameliorated the investigated parameters in the HCC/Prop group.ConclusionPropranolol exhibited an anticancer effect and thus can be considered as a promising treatment for HCC. Blocking of PD‐1/PD‐L1 and LAG‐3 signals participated in the anti‐tumor effect of propranolol on HCC.
Records of urban occurrences expand estimates of the climate niches in tree species
Authors: Das S. , Ossola A. , Beaumont L. J. 
Published: February 2024

AbstractAimQuantifying a species' climate niche is often the first step to determining potential sensitivity to climate change. This process typically relies on native occurrence records, assuming that these reflect the breadth of a species' climatic requirements. Yet, many species survive in non‐native regions with climates beyond their native range. Identifying their characteristics could help to better elucidate responses to climate change. Here, we use an extensive data set of urban street tree and native range records for 566 tree species to assess differences between species native and urban climate niches and whether niche differences are predictable given characteristics of species native ranges.LocationGlobal.Time Period1970–2020.Major Taxa StudiedTree species.MethodsMultivariate niche estimations were undertaken using eight climate variables. Calculations included the size of species' urban and native niches, overlap and direction of shift. Relationships between niches and native range attributes (temperature and precipitation breadth, range size, Köppen Geiger subclasses occupied) were calculated using multiple linear regression.Results83% of tree species studied had significantly larger urban niches compared to native niches. Species with narrow geographic ranges demonstrated greater mismatch between their two niches, and the direction of niche shift was associated with their native range Köppen Geiger zone. For example, species native to the wet tropics tend to be planted in cooler, drier urban spaces; those native to cold regions are planted in warmer urban spaces.Main ConclusionNative range occurrences may poorly reflect the breadth of climatic conditions a species can tolerate—particularly for species with narrow geographic ranges. For some species, Köppen Geiger zones may be a useful proxy to help understand sensitivity to climate change. Accounting for possible plasticity in tree species to climate can improve our understanding of their sensitivity and adaptive capacity to climate change.