bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postnatal development of central corneal thickness in chicks ofGallus gallus domesticus
Authors: Montiani‐Ferreira Fabiano , Cardoso Fernando , Petersen‐Jones Simon 
Published: January 2004

AbstractObjective To investigate the changes in corneal thickness that occur during maturation of theGallus gallus domesticuschick eye over the first 450 days of life.Animals studied Twenty‐nine chicks, of which 12 were males and 17 were females.Procedures The central corneal thickness (CCT) was measured by ultrasonic pachymetry from hatch until 450 days of age. Segmented regression was applied to capture the two phases observed in the CCT plotted against age. Eye and gender were also included in the model.Results Mean CCT values initially decreased, with the lowest point being reached at around 12 days of age. CCT then gradually increased as the chick matured. At 70 days of age the animals have completed corneal development and reached the plateau value of 0.242 ± 0.0002 mm. CCT differences between gender or between left and right eyes were not statistically significant. Prediction equations for mean CCT according to the bird's age are presented.Conclusions There is an initial decrease in corneal thickness until approximately 12 days of age, which presumably mirrors maturation of corneal endothelial cell function. The pattern of changes in corneal thickness during the first phase of development of the chick CCT was similar to the one reported for dogs and humans. However, a unique feature of the development of CCT in chicks is that after reaching a plateau at 70 days corneal thickness did not significantly change over the remainder of the study period. Additionally, unlike in humans and dogs, there is no gender difference for corneal thickness in chicks.
Cardiovascular effects of topical ophthalmic 10% phenylephrine in dogs
Authors: Herring I. P. , Jacobson J. D. , Pickett J. P. 
Published: January 2004

AbstractObjective To evaluate the effect of topical ophthalmic 10% phenylephrine on systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), pulse rate (PR) and electrocardiogram (ECG) in dogs.Animals studied Nine clinically normal dogs.Procedure Arterial catheters were placed in the dorsal pedal artery of awake dogs and ECG leads were attached. After a 15‐min acclimatization period, baseline PR, SAP, DAP and MAP were recorded every 5 min for 20 min. Two treatment groups (eight dogs each) were studied.Group I: one drop of phenylephrine was placed in each eye once.Group II: one drop of phenylephrine was placed in each eye three times at 5‐min intervals. Following treatment, PR, SAP, DAP and MAP were recorded every 5 min for 90 min. The mixed procedure of the SAS system was used to perform a repeated measures analysis of variance to test for linear and quadratic trends across time.Results Group I: There was a significant quadratic decrease in PR across time (P = 0.0051). Systolic arterial pressure increased linearly with time (P = 0.0002), MAP increased linearly with time (P = 0.0131), and DAP increased linearly with time (P = 0.0001).Group II: There was a significant quadratic decrease in PR across time (P = 0.0023). There was a significant quadratic increase in SAP (P = 0.0324), MAP (P = 0.0103) and DAP (P = 0.0131) across time.Conclusions Topical ophthalmic application of 10% phenylephrine in normal dogs results in elevation of arterial blood pressure and reflex bradycardia.
Abnormal dark‐adapted ERG in cats heterozygous for a recessively inherited rod‐cone degeneration
Authors: Ekesten Björn , Narfström Kristina 
Published: January 2004

AbstractPurpose  To study retinal function in cats homozygous and heterozygous for a recessively inherited rod‐cone degeneration.Methods  Dark‐adapted electroretinograms (ERGs) were performed on early affected, heterozygous (ophthalmoscopically normal), and clinically normal, nonrelated cats. Responses to blue stimuli over a 3.9‐log unit range were recorded.Results  Lower b‐wave amplitudes than normal were observed in heterozygotes and early affected cats. The amplitudes of the heterozygotes took an intermediate position between normal and early affected cats. Normalized amplitude/intensity data suggest a normal dynamic range in carriers. B‐wave implicit times in carriers were comparable to those of normal cats.Conclusions  These results show that heterozygotes have an altered retinal function, although they are ophthalmoscopically normal. It is difficult to electrophysiologically differentiate heterozygotes from affected cats with the very early stage of retinal degeneration.
Canine lobular orbital adenoma: a report of 15 cases with distinctive features
Authors: Headrick Jason F. , Bentley Ellison , Dubielzig Richard R. 
Published: January 2004

AbstractObjective  To describe a unique orbital neoplasm in dogs, of lacrimal or salivary gland origin.Animals studied  Fifteen dogs with lesions consistent with a diagnosis of lobular adenomas involving the orbit were identified from the Comparative Ophthalmic Pathology Laboratory of Wisconsin from 1994 to 2001.Results  The neoplasm occurred in nine females and six males. Affected dogs ranged in age from 7 to 17 years (mean = 9.7 years). Follow‐up information was available for 13 of the 15 cases. The clinical presentation included swollen/hyperemic eyelids (4/15), third eyelid protrusion (3/15), conjunctival mass (6/15), exophthalmos (4/15), resistance to retropulsion (2/15), or strabismus (1/15). In 13 cases the masses were composed of nodular, friable tissue and they were solid in two cases. Histologically, the tissue was found in encapsulated lobules resembling well differentiated lacrimal or salivary glands but completely lacking ducts. Granular PAS‐positive material was found within the cytoplasm. There was recurrence in 10 of the 13 cases available for follow‐up. Of those cases in which enucleation or exenteration was performed (3/15), there was recurrence of disease in one case. In three cases the dogs were euthanized before recurrence at 3 months, 5 months and 3 years post surgery. None of the deaths was related to the tumor.Conclusion  In the 15 cases reviewed, lobular adenomas of the orbit presented clinically and histologically as a benign neoplasm of lacrimal or salivary gland origin. Recurrence was likely unless the mass was completely excised, at times requiring orbital exenteration.
Effect of different dose schedules of travoprost on intraocular pressure and pupil size in the glaucomatous Beagle
Authors: Gelatt Kirk N. , MacKay Edward O. 
Published: January 2004

AbstractObjective To evaluate changes in intraocular pressure and pupil size in glaucomatous dogs after instillation of 0.004% travoprost once in the morning, or once in the evening, or twice daily in 5‐day multiple dose studies.Materials and methods Applanation tonometry (IOP) and pupil size (PS) measurements were obtained at 8 a.m., 10 a.m., 12 noon, 2 p.m. and 4 p.m. in eight glaucoma dogs. Methylcellulose (0.5% as placebo) was instilled in the control eye, and 0.004% travoprost was instilled in the opposite drug eye. Methylcellulose (0.5%) and 0.004% travoprost were instilled on the 2nd through to the 5th day with instillations in the morning (8.30 a.m.), or evening (8 p.m.), or twice daily (8.30 a.m. and 8 p.m.).Results The mean ± SEM diurnal changes from baseline IOP in the control and placebo eyes in all three studies ranged from 1.2 ± 0.3 mmHg to 3.2 ± 0.9 mmHg. The mean ± SEM diurnal changes from the baseline IOP after 0.004% travoprost at 8 a.m. once daily for the next 4 days were 19.0 ± 2.7 mmHg, 24.7 ± 2.7 mmHg, 24.9 ± 3.1 mmHg, and 24.7 ± 3.1 mmHg, respectively, and were significantly different from the control eye. After travoprost was instilled at 8 p.m., the mean ± SEM baseline changes from the baseline IOP in the drug eyes were 23.5 ± 2.2 mmHg, 24.2 ± 2.2 mmHg, 24.5 ± 2.3 mmHg, and 24.2 ± 2.3 mmHg, respectively. When 0.004% travoprost was instilled twice daily, the mean ± SEM baseline IOP changes were 27.7 ± 2.1 mmHg, 28.1 ± 2.1 mmHg, 28.4 ± 2.2 mmHg, and 28.5 ± 2.2 mmHg, respectively, and were significantly different from the control eyes. Miosis of varying duration was frequent during the three studies.Conclusion Travoprost instilled once daily (a.m. or p.m.) as well as twice daily produces significant decreases in IOP and PS in the glaucomatous Beagle.
Enhanced expression of Cyclooxygenase‐2 in glaucomatous dog eyes
Authors: Marshall Janene L. , Stanfield Kristina M. , Silverman Lee , Khan K. Nasir M. 
Published: January 2004

AbstractObjective  Cyclooxygenase‐2 (COX‐2)‐derived prostaglandins (PGs) are shown to play important pathophysiologic roles in various disease states. Recently, the effectiveness of topical PGs in reducing intraocular pressure (IOP) has stimulated further interest in the physiologic function of COX‐2 and PGs in normal and glaucomatous eyes. Therefore, we investigated the cell‐type distribution and expression of COX‐2 in normal and glaucomatous dog eyes.Procedures  Using isoform‐specific antibodies, we immunohistochemically evaluated COX‐2 expression in formalin‐fixed and paraffin‐embedded normal (n = 5) and glaucomatous (n = 17) dog eyes.Results  In the normal eyes, only minimal COX‐2 immunoreactivity was observed in the ciliary epithelium. In the glaucomatous eyes, COX‐2 expression was further observed in the cornea and corneoscleral limbus. In the cornea, moderate to strong COX‐2 expression was observed in all corneal layers (epithelium, stromal cells and endothelium), with the greatest expression present in the epithelial layer. In the corneoscleral limbus area, COX‐2 immunoreactivity was noted in the stromal cells of sclera, trabecular meshwork and endothelial cells of the angular aqueous plexus.Conclusions  Increased expression of COX‐2 in dog glaucomatous eyes suggests that COX‐2‐derived PGs may have a potential role in the pathogenesis of canine glaucoma.
Hypertensive retinopathy and choroidopathy in a cat
Authors: Komáromy András M. , Andrew Stacy E. , Denis Heidi M. , Brooks Dennis E. , Gelatt Kirk N. 
Published: January 2004

AbstractBilateral hypertensive retinopathy and choroidopathy with bullous retinal detachment was diagnosed in a 17‐year‐old, female spayed Domestic Short‐haired cat. The underlying cause of the systemic hypertension could not be determined. The blood pressure was lowered successfully with the oral application of the L‐type calcium channel blocker amlodipine besylate. The cat subsequently regained vision. The improvement in retinal function was documented using electroretinography.
Firm Size, Industry Mix and the Regional Transmission of Monetary Policy in Germany
Authors: Arnold Ivo J. M. , Vrugt Evert B. 
Published: January 2004

AbstractThis paper estimates the impact of interest rate shocks on regional output in Germany over the period from 1970 to 2000. We use a vector autoregression (VAR) model to obtain impulse responses, which reveal differences in the output responses to monetary policy shocks across ten German provinces. Next, we investigate whether these differences can be related to structural features of the regional economies, such as industry mix, firm size, bank size and openness. An additional analysis of the volatility of real GDP growth for the period 1992-2000 includes the Eastern provinces. We also present evidence on the interrelationship between firm size and industry, and compare our measure of firm size with those used in previous studies. We conclude that the differential regional effects of monetary policy are related to industrial composition, but not to firm size or bank size.
Strategies for Fiscal Reform in the Context of the EMU: the Case of Portugal
Authors: Pereira Alfredo M. , Rodrigues Pedro G. 
Published: January 2004

AbstractThe authors use an endogenous growth dynamic general‐equilibrium model, which accommodates the institutional constraints of the Stability and Growth Pact, to study tax reform in Portugal. Simulation results suggest that tax cuts financed in a nondistortionary way increase long‐term GDP; i.e., they are efficiency improving, but do not always increase welfare. The tradeoff between efficiency and welfare is alleviated when reductions in public spending or increased public indebtedness finance the tax cuts. Since these mechanisms are not realistic under the institutional setting of the Stability and Growth Pact, tax reform in Portugal must involve trading off distortionary tax margins. In this case, the best strategy to increase both efficiency and welfare is to increase investment tax credits and finance them either through personal income taxes or through employers’ social security contributions.
CRAS‐CBR: Internal control risk assessment system using case‐based reasoning
Authors: Hwang Sung‐Sik , Shin Taeksoo , Han Ingoo 
Published: January 2004

Abstract: Information technology and the Internet have been major drivers for changes in all aspects of business processes and activities. They have brought major changes to the financial statements audit environment as well, which in turn has required modifications in audit procedures. There exist certain difficulties, however, with current audit procedures especially for the assessment of the level of control risk. This assessment is primarily based on the auditors' professional judgment and experiences, not on objective rules or criteria.To overcome these difficulties, we propose a prototype decision support model named CRAS‐CBR using case‐based reasoning to support auditors in making their professional judgment on the assessment of the level of control risk of the general accounting system in the manufacturing industry.To validate the performance, we compare our proposed model with benchmark performances in terms of classification accuracy for the level of control risk. Our experimental results show that CRAS‐CBR outperforms a statistical model and staff auditor performance in average hit ratio.
Art History?
Authors: Brook Donald 
Published: January 2004

abstractThis article is presented in two parts. In part I, I call into question the viability of a currently received opinion about the foundations of the subject called “Art History,” primarily by challenging assumptions that are implicit in conventional uses of the terms “art” and “work of art.” It is widely supposed that works of art are items of a kind, that this kind is the bearer of the name “art,” and that it has a history. In part II, I propose to correct this error by using the word “art” in a presently unconventional—although not unprecedented—way. The proposal relies upon a concept of cultural evolution running intellectually parallel to a Darwinian account of genetic evolution. The thesis has strong metaphysically realist implications, relating cultural evolution to what can be said and done and can properly be seen to have a history only in a universe to which real regularities are attributed. The recommended use of the term “art” is secured upon an estimate of the role of memetic innovation as radically pervasive, embracing all thought and action. “Art,” understood in the suggested way, becomes the name of a category, which has no history as kinds have histories.
What Do Historians Argue About?
Authors: Mccullagh C. Behan 
Published: January 2004

abstractThose who think that general historical interpretations do no more than express a personal point of view deny that arguments over their credibility can have any point. They commonly believe that historians decide upon particular facts about the past in the context of a general interpretation of those facts. Consequently they deny that there is any independent basis for judging the credibility of general interpretations of the past, and conclude that each coherent account is as good as every other.Similarly, those who think causal explanations are arbitrary can make no sense of arguments about their adequacy. They assume that historians simply pick out causes that interest them, and that there is no objective basis for judging the adequacy of the explanations they provide.This essay defends the credibility of interpretations against the skeptics, and the adequacy of causal explanations too. It shows that historians do discover a mass of particular facts independently of the general interpretations they finally provide, facts that provide a basis for assessing the credibility and fairness of those interpretations. It will also show that there is an objective basis for judging the adequacy of causal explanations, as some causes of an event are far more influential in bringing it about than others.A much more difficult problem concerns the need for historical interpretations to provide not just a credible account of the past, but also one that is fair, balanced, not misleading. Historians frequently argue about the fairness of general interpretations. Does this mean that fairness is always required? Quite often historians produce partial interpretations, in both senses, with no apology. It would be wrong to call such interpretations “biased” because they do not pretend to be comprehensive. So long as they are credible, they are acceptable. On the other hand, many interpretations are intended to present a fair, comprehensive account of their subject. When judging the adequacy of interpretations, it is necessary to know whether they are meant to be fair or not.
The “Return of the Subject” As a Historico‐Intellectual Problem
Authors: Palti Elías 
Published: January 2004

abstractRecently, a call for the “return of the subject” has gained increasing influence. The power of this call is intimately linked to the assumption that there is a necessary connection between “the subject” and politics (and ultimately, history). Without a subject, it is alleged, there can be no agency, and therefore no emancipatory projects—and, thus, no history. This paper discusses the precise epistemological foundations for this claim. It shows that the idea of a necessary link between “the subject” and agency, and therefore between the subject and politics (and history) is only one among many different ones that appeared in the course of the four centuries that modernity spans. It has precise historico‐intellectual premises, ones that cannot be traced back in time before the end of the nineteenth century. Failing to observe the historicity of the notion of the subject, and projecting it as a kind of universal category, results, as we shall see, in serious incongruence and anachronisms. The essay outlines a definite view of intellectual history aimed at recovering the radically contingent nature of conceptual formations, which, it alleges, is the still‐valid core of Foucault's archeological project. Regardless of the inconsistencies in his own archeological endeavors, his archeological approach intended to establish in intellectual history a principle of temporal irreversibility immanent in it. Following his lead, the essay attempts to discern the different meanings the category of the subject has historically acquired, referring them back to the broader epistemic reconfigurations that have occurred in Western thought. This reveals a richness of meanings in this category that are obliterated under the general label of the “modern subject”; at the same time, it illuminates some of the methodological problems that mar current debates on the topic.
Inductive interactions and embryonic equivalence groups in a basal metazoan, the ctenophore Mnemiopsis leidyi
Authors: Henry Jonathan Q. , Martindale Mark Q. 
Published: January 2004

SummaryCtenophores undergo locomotion via the metachronal beating of eight longitudinally arrayed rows of comb plate cilia. These cilia are normally derived from two embryonic lineages, which include both daughters of the four e1 micromeres (e11 and e12) and a single daughter of the four m1 micromeres (the m12 micromeres). Although the e1 lineage is established autonomously, the m1 lineage requires an inductive interaction from the e1 lineage to contribute to comb plate formation. Successive removal of the e1 progeny at later stages of development indicates that this interaction takes place after the 32‐cell stage and likely proceeds over a prolonged period of development. Normally, the e11 cell lies in closest proximity to the m12 cell that generates comb plate cilia; however, either of the e1 daughters (e11 or e12) is capable of emitting the signal required for m1 descendants to form comb plates. Previous cell lineage analyses indicate that the two e1 daughters generate the same suite of cell fates. On the other hand, the m1 daughters (m11 and m12) normally give rise to different cell fates. Reciprocal m1 daughter deletions show that in the absence of one daughter, the other cell can gene‐rate all the cell types normally formed by the missing cell. To‐gether, these findings demonstrate that the two m1 daughters (m11 and m12) represent an embryonic equivalence group or field and that differences in the fates of the two m1 daughters are normally controlled by cell–cell interactions. These combined properties of ctenophore development, including the utilization of deterministic cleavage divisions, inductive interactions, and the establishment of embryonic fields or equivalence groups, are remarkably similar to those present in the development of various bilaterian metazoans.
How different types of pattern formation mechanisms affect the evolution of form and development
Authors: Salazar‐ciudad Isaac , Jernvall Jukka 
Published: January 2004

SummaryHere we investigate how development and evolution can affect each other by exploring what kind of phenotypic variation is produced by different types of developmental mechanisms. A limited number of developmental mechanisms are capable of pattern formation in development. Two main types have been identified. In morphodynamic mechanisms, induction events and morphogenetic processes, such as simple growth, act at the same time. In morphostatic mechanisms, induction events happen before morphogenetic mechanisms, and thus growth cannot influence the induction of a pattern. We present a study of the variational properties of these developmental mechanisms that can help to understand how and why a developmental mechanism may become involved in the evolution and development of a particular morphological structure. Using existing models of pattern formation in teeth, an extensive simulation analysis of the phenotypic variation produced by different types of developmental mechanisms is performed. The studied properties include the amount and diversity of the phenotypic variation produced, the complexity of the phenotypic variation produced, and the relationship between phenotype and genotype. These variational properties are so different between different types of mechanisms that the relative involvement of these types of mechanisms in evolutionary innovation and in different stages of development can be estimated. In addition, type of mechanism affects the tempo and mode of morphological evolution. These results suggest that the basic principles by which development is organized can influence the likelihood of morphological evolution.
Proximodistal patterning of the limb: insights from evolutionary morphology
Authors: Richardson Michael. K. , Jeffery Jonathan E. , Tabin Clifford J. 
Published: January 2004

SummaryThere is an active debate about how skeletal elements are encoded along the proximodistal (PD) axis of the developing limb. Our aim here is to see whether consideration of the evolutionary morphology of the limb can contribute to our understanding of patterning mechanisms. Of special interest in this context are animals showing reiterated skeletal elements along the PD axis (e.g., dolphins and plesiosaurs with hyperphalangy). We build on previous hypotheses to propose a two‐step model of PD patterning in which specification of broad domains in the early limb bud is distinct from subsequent processes that divides an initial anlage into a segmental pattern to yield individual skeletal elements. This model overcomes a major evolutionary problem with the progress zone model, which has not previously been noted: pleiotropy. Parallels with other developmental systems are briefly discussed.