bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase-amplitude coupling during auditory steady-state stimulation: a methodological review
Authors: Mockevičius Aurimas , Griškova-Bulanova Inga 
Published: February 2025

Abstract
Auditory steady-state response (ASSR) is a robust method to probe gamma (>30 Hz) activity in a controlled manner. While typically the magnitude and the phase synchronization over stimulus repetitions of ASSR is assessed, other measures are being investigated. One of them is phase-amplitude coupling (PAC), which reflects the interactions between lower frequency phase and higher frequency amplitude. Considering that the number of studies assessing PAC during auditory steady-state stimulation has grown recently, in the present work, we aimed to perform a comprehensive overview of PAC methodological approaches in ASSR studies. We sought to evaluate the studies according to PAC analysis issues emphasized in empirical and theoretical PAC studies. Our work showed considerable variability in the methodology among the reviewed studies. Furthermore, the reviewed works address methodological issues and confounding factors of PAC relatively poorly and are characterized by insufficient descriptions of the applied approaches. Our review shows that systematic research of PAC in the context of ASSR is imperative in order to properly evaluate the presence of PAC during the auditory steady-state stimulation.
Les IA génératives visuelles entre perception d’archives et circuits de composition
Authors: D’Armenio Enzo 
Published: February 2025

Résumé
Cet article aborde les intelligences artificielles génératives visuelles telles que Midjourney et DALL·E afin d’analyser leur fonctionnement sémiotique. Le point de départ est la définition de la discipline sémiotique proposée par Pierluigi Basso Fossali, décrivant celle-ci comme la science qui étudie la gestion sociale du sens, et qui s’articule en quatre sphères fondamentales : la perception, l’énonciation, la communication et la transmission. À partir de ce cadre théorique, l’objectif est de proposer et de décrire deux nouvelles configurations qui caractérisent le fonctionnent sémiotique des IA génératives visuelles : à travers une perception d’archives et grâce à des circuits de composition. Le concept de perception d’archives a pour objectif de décrire la manière particulière dont les IA voient, entendent et apprennent, celle-ci étant réalisée sur de grandes quantités de données et à travers une généalogie d’opérations reconfigurables sur les archives. Les circuits de composition, quant à eux, concernent le couplage entre la logique de la composition visuelle et de la prédication verbale : il s’agit du processus d’énonciation par débruitage visuel réalisé par les IA, guidé par les requêtes en langage naturel fournies par des opérateurs humains. À partir de trois critères élaborés en sémiotique – les catégories plastiques, l’énonciation visuelle, ainsi que la traduction intersémiotique entre textes verbaux et images – une série de tests seront proposés afin d’examiner les circuits de composition des modèles génératifs de Midjourney et de DALL·E. Les IA seront enfin définies en tant que machines co-énonçantes : des entités dépourvues d’intentionnalité et d’initiative, qui produisent pourtant des énoncés en collaboration avec un opérateur humain et sur la base d’archives de données hautement structurées et reconfigurables.
Morphological, antioxidant, and antidiabetic properties of bitter gourd (Momordica charantia L.) juice and turmeric (Curcuma longa) powder encapsulated in chickpea protein isolate
Authors: Muzaffar H. , Wani I.A. 
Published: February 2025

AbstractThis study successfully microencapsulated bitter gourd juice (EBG) and turmeric powder (ET) using chickpea protein isolate via freeze-drying, achieving encapsulation efficiencies of 85.3% and 89.5%, respectively. Particle size analysis revealed sizes of 3.69 µm for EBG and 4.97 µm for ET. FTIR confirmed the successful entrapment of core materials within the protein matrix. Although unencapsulated samples exhibited higher activity levels, the encapsulated forms also demonstrated significant antioxidant, antidiabetic, and anti-lipidemic properties, with effective protection and controlled release of active components in the gastrointestinal environment. This highlights their potential as functional ingredients for managing type 2 diabetes and hyperlipidaemia in food products.
Nutritional and metabolic parameters of sheep fed extruded roughage
Authors: Oliveira Karla Alves , Siqueira Marco Túlio Santos , Oliveira Marcela Rodrigues de , Dutra Thamiris Oliveira , Sousa Luciano Fernandes , Macedo Júnior Gilberto de Lima 
Published: February 2025

The search for technologies to increase productivity of the herds, without increasing production costs, brings a positive highlight to extruded feeds, since these products act to maximize digestive efficiency. The objective was to evaluate the effect of using different levels of inclusion of extruded roughage to replace corn silage on nutritional and metabolic parameters in sheep. For this, 20 ewes aged over three years were used, housed in metabolic cages, distributed in a completely randomized design in four treatments, which consisted of different levels of inclusion of extruded roughage to replace corn silage (20%, 40%, 60% and 80%). Dry matter intake (DMI) and water intake were calculated by the difference between what was offered and what was left over. Blood glucose and energy and protein metabolites were obtained through blood collection by jugular venipuncture and subsequent laboratory analyses, and feeding behavior by observation every 5 min. for 24 h. DMI and water intake increased linearly with the inclusion of extruded roughage in the diet. The greater inclusion of extruded roughage reduced the total chewing time, consequently increasing the efficiency of ingestion, rumination and total chewing. The inclusion of extruded roughage in the diet of sheep increases the dry matter intake, without reducing the digestibility of nutrients, reducing the time spent on chewing.
Pendekatan Holistik dalam Penilaian Istitha'ah Kesehatan Jamaah Haji Lansia dengan Sindrom Metabolik dan Komorbiditas : Sebuah Laporan Kasus
Authors: Olivia Virgi , Suci Andini Nurul , Hamad Uwaist Ghozi , Muhammad Aan Tri Lutfi , Aima Halida Hasyati 
Published: February 2025

Latar BelakangIbadah haji memerlukan kondisi kesehatan optimal untuk memastikan calon jamaah dapat menjalankan seluruh rangkaian ibadah dengan baik. Penilaian kesehatan calon jamaah menjadi salah satu langkah esensial, terutama pada lansia dengan penyakit penyerta. Dokter memiliki peran sentral dalam menilai status istitha'ah, memberikan edukasi kesehatan, serta merancang intervensi yang mendukung kebugaran fisik jamaah.
Presentasi KasusSeorang perempuan berusia 77 tahun menjalani pemeriksaan kesehatan rutin untuk penilaian istitha'ah. Riwayat penyakit pasien mencakup Diabetes Mellitus Tipe 2 dan Hipertensi Grade 2. Pemeriksaan fisik menunjukkan tekanan darah 160/99 mmHg dengan hasil tes enam menit berjalan sejauh 255 meter, yang termasuk kategori "kurang sekali". Pemeriksaan penunjang menunjukkan HbA1C 8%, trigliserida 338 mg/dl, serta radiologi dengan gambaran kardiomegali. Pasien didiagnosis sindrom metabolik dengan komplikasi kardiomegali dan ditetapkan dalam kategori istitha'ah dengan pendampingan obat.
PembahasanPendekatan manajemen pasien meliputi tatalaksana promotif, preventif, kuratif, dan rehabilitatif. Promosi kesehatan mencakup edukasi terkait pola hidup sehat, seperti peningkatan aktivitas fisik dan diet rendah gula serta garam. Tatalaksana kuratif dilakukan dengan pemberian antihipertensi, terapi insulin, dan hipolipidemik. Intervensi holistik ini dirancang untuk mengoptimalkan kesehatan pasien dan mencegah komplikasi lebih lanjut.
Simpulan Kesiapan kesehatan jamaah haji, terutama lansia dengan komorbiditas, memerlukan pendekatan holistik yang mencakup aspek fisik, sosial, dan psikologis. Peran dokter sangat penting dalam memastikan kesehatan jamaah tetap optimal, melalui edukasi, tatalaksana, dan dukungan berkesinambungan untuk mendukung kesuksesan ibadah haji.
Kata kunci : Istitha'ah kesehatan, Sindrom metabolik, Diabetes Mellitus Tipe 2, Hipertensi, Pendekatan holistik
Preoperative Optimization Strategies in Elective Spine Surgery
Authors: Daniels Alan H. , Singh Manjot , Knebel Ashley , Thomson Cameron , Kuharski Michael J. , De Varona Abel , Nassar Joseph E. , Farias Michael J. , Diebo Bassel G. 
Published: February 2025

» Although spine surgery is effective in reducing pain and improving functional status, it is associated with unacceptably high rates of complications, thus necessitating comprehensive preoperative patient optimization.» Numerous risk factors that can impact long-term surgical outcomes have been identified, including malnutrition, cardiovascular disease, osteoporosis, substance use, and more.» Preoperative screening and personalized, evidence-based interventions to manage medical comorbidities and optimize medications can enhance clinical outcomes and improve patient satisfaction following spine surgery.» Multidisciplinary team-based approaches, such as enhanced recovery after surgery protocols and multidisciplinary conferences, can further facilitate coordinated care from across specialties and reduce overall hospital length of stay.
Effect of Nonreactive Minerals on Acid-Etching Hydraulic Fracture Behavior and Conductivity in Carbonate Rocks
Authors: Gou Bo , Liu Zi-Hao , Guo Jian-Chun , Pu Kun , Ren Ji-Chuan , He Le , Guo Ling-Yao 
Published: February 2025

Summary
Nonreactive minerals, such as quartz and talc, are frequently observed in carbonate reservoirs due to the sedimentary environment and geological processes. However, scant attention has been given by scholars to the impact of these nonreactive minerals on acid-etched fracture morphology and conductivity during acid fracturing. To clarify the acid flow and reaction behavior in carbonate rock composed of complex minerals, a mineral characterization model simultaneous for calcite, dolomite, and nonreactive minerals is first developed in this paper. Then, combined with the thermal-hydraulic-chemical coupling acid-etching model, it can study the impact of mineral content and distribution on the acid-etching fracture behavior. In addition, the acid-etching model is validated by acid-etching laboratory experiments, and the acid-fracture conductivity model is also established by testing the conductivity of rock slabs with different mineral compositions. Based on the new model, the effects of different mineral compositions on the acid flow behavior, effective acid penetration distance (EAPD), and conductivity were investigated. The research results show that the mechanism of nonreactive mineral to increase EAPD depends on the initial hydraulic fracture width, mineral distribution, and content. The acid concentration profile along the fracture length has the feature of segmentation when the circumferential flow phenomenon occurs. With the increase of the nonreactive mineral content, the EAPD increasing rate in the calcite-nonreactive mineral interaction distribution formation is faster than that in calcite-dolomite. The impact of the nonreactive mineral on conductivity is large in limestone but can be ignored in dolomite. These ﬁndings can provide guidance for the design of acid fracturing in such siliceous carbonate reservoirs.
The effect of a vegan diet with or without resistance exercise on thigh muscle volume in older adults. Research protocol of the Vold-study: a 12-week randomized controlled trial
Authors: Domić Jacintha , Grootswagers Pol , Pinckaers Philippe JM , Groenendijk Inge , Rubert Josep , Loon Luc JC , Groot Lisette CPGM 
Published: February 2025

Abstract

Background
Plant-based diets are increasingly adopted. While augmenting plant-based food consumption holds important health benefits, plant-based foods exhibit a lower protein quantity and quality compared to animal-based foods. As such, a fully plant-based, i.e. vegan, diet may be suboptimal for the maintenance of skeletal muscle mass later in life. The primary objectives of this study protocol are therefore: 1) To assess the effect of a 12-week self-composed vegan diet in comparison to an omnivorous diet on thigh muscle volume in community-dwelling older adults; and 2) To assess the effect of a 12-week vegan diet combined with twice-weekly resistance exercise on thigh muscle volume in comparison to a vegan diet without resistance exercise in community-dwelling older adults.
Methods
Seventy-two community-dwelling individuals aged ≥ 65 years with a BMI between 23–32 kg/m2 will be included in this randomized controlled trial and will be randomly allocated to either follow their habitual omnivorous diet, a self-composed vegan diet, or a self-composed vegan diet combined with two sessions of resistance exercise per week for 12 weeks. Participants will be guided through monthly nutrition information meetings. Dietary intake and physical activity levels will be assessed using food records and accelerometery. The primary study outcome will be thigh muscle volume, assessed at baseline and after 12 weeks using magnetic resonance imaging. Secondary outcomes will be: fat distribution; muscle fat infiltration; muscle strength; bone mineral density; bone turnover markers; metabolic profile; insulin levels; cobalamin, iron and vitamin D status; gut metabolomics and metagenomics; gastro-intestinal symptoms; dietary intake. Measurements will take place at baseline, after 6 weeks, and after 12 weeks. Additionally, mixed muscle protein synthesis rates will be assessed during the first ten days of the intervention using a deuterium oxide protocol. Data will be analysed using independent t-tests and linear mixed models.
Discussion
The results will provide valuable insights regarding the implications of consuming a vegan diet later in life for skeletal muscle and other health outcomes and may contribute to the substantiation of the envisaged more plant-based dietary guidelines.
Trial registration:
The trial is registered at clinicaltrials.gov (NCT05809466; registered on 22 February 2023).
Effect of aspect ratio and load location on the structural response of catenary arches under concentrated loading
Authors: Teixeira Damiano Luis , Merwe Johann Eduard van der 
Published: February 2025

Abstract

The construction industry contributes substantially to global greenhouse gas emissions. The embodied carbon in reinforced concrete floors accounts for a large part of embodied carbon in building structures. Optimising the form of horizontal spanning structures will not only reduce the volume of material needed for these structures but might also reduce the size of foundations. It is well-known that a catenary arch is the optimal form to ensure pure compression throughout. Although this might be an ideal shape for horizontal spanning systems under a uniformly distributed load, the effect of concentrated loads must also be considered. This study investigated the impact of the span-to-depth aspect ratio on the response of arches under concentrated loads, both central and eccentric concentrated loads. Through a numerically validated experimental campaign, the aspect ratio of an arch influences the resistance of loading from which it was formed.
Internet Addiction, Cyberbullying and their effect on Mental Health: A study of University Students
Authors: Barman Tapan Kumar , Kumar Hiren 
Published: February 2025

Abstract

Background: The research has explored internet addiction, cyberbullying and their effect on mental health. Todays, internet addiction and cyberbullying are most sensitive topics in throughout the world especially in young students. Internet addiction is an excessive or uncontrolled online activities that causes pathological distress among users. Moreover, cyberbullying is an aggressive and deliberate activities within online platform that occurs by a person or group. However, there are some researches rigorously exploring the concept of internet addiction, cyberbullying and mental health of young adults.
Methods: To study internet addiction, cyberbullying and mental health of 314 randomly selected university students were measured by an adapted Bangla version of internet addiction test, cyberbullying scale and mental general health questionnaire. In order to analyze the effect of internet addiction and cyberbullying on mental health the subjects were classified into three groups (minimal, moderate and excessive) and comparison were made among three groups. To complete the analysis standard procedure was followed and then one way ANOVA, t test, post-hoc and Pearson’s correlation test were applied.
Results: A total of 314 students, among them 56.37% were males and 43.63% were females. The age range of the respondents was 19-21 years. Firstly, results stated that that minimal internet addicted students had significantly better mental health than moderate and excessive internet addicted students and mild cyberbullying victim students had significantly better mental health than moderate and severe cyberbullying victim students. Secondly, the results showed that internet addiction and cyberbullying were positively correlated (r=.406, p= 0.001) each other. And finally, the study also expressed that internet addiction (r=-.533, p= 0.001) and cyberbullying (r=-.592, p= 0.001) were negatively correlated mental health.
Conclusions: The findings of the research suggest that the excessive internet activity leads to psychological disturbance. It also affects daily functioning, quality relationships and academic performance for students. Similarly, cyberbullying also hampers psychological well-being and creates psychiatric problems. Finally, it also stated that internet addiction and cyberbullying had badly affected students’ psychological well-being and daily life functioning because internet addiction and cyberbullying positively correlated.
Functional Imaging of Developing Brain in Mice and Non-Human Primates
Authors: Qiu Zhihai , zhu Jiejun , He Dongming , Sun Mengzhu , Zheng Hanming , Chen Zihao , Yang Jin , Lin Chengqi , Yuan Wiwen , Shi Yun , Sun Lei 
Published: February 2025

Abstract

Despite significant advances in structural and genetic studies, investigations of early embryonic functions, such as brain activity, have long been constrained by technical challenges. Functional ultrasound (fUS) has emerged as a breakthrough modality, enabling real-time monitoring of brain activity with exceptional spatial and temporal resolution and offering unprecedented opportunities for studying functional embryonic development. In this study, we used fUS to monitor whole-embryo activity in mice from embryonic days E8.5 to E18.5, revealing patterns of neural activity throughout embryogenesis. This approach provides new opportunities to explore brain development dynamically as it unfolds. Moreover, we observed embryo responses to external stimuli, including sound, in both mice and cynomolgus macaques, offering insights into early sensory processing and neural maturation. In summary, our study establishes fUS as a powerful tool for studying embryonic brain functional development, with significant implications for scientific research, especially in non-human primate models, and clinical applications.
Ambient air pollution exposure and child birthweight in East African countries: Identifying the sensitive periods
Authors: Baharane Valérien , Shatalov Andrey Borisovich , Larionov Maxim Viktorovich , Korsakov Anton V. 
Published: February 2025

Abstract

This article assessed the impacts of prenatal exposure to PM2.5, CO and O3 on the child’s birth weight in five East African countries trying to identify the susceptible exposure periods. The adjusted linear regression model showed that the increase in 1 µg/m3 in O3 exposure during the first, second and third pregnancy trimesters, respectively resulted in the reduction of the birthweight by 0.00300 kg (Standard Error (SE) of 0.00092 kg), 0.00232 kg (SE: 0.0093), 0.00164 kg (SE: 0.00096) and 0.00674 kg (SE: 0.00143). The logistic regression model revealed that a 1 µg/m3 increase in prenatal exposure to O3 concentration is associated with 4.7% (95% Confidence Interval (CI): 0.4487-1.4434) and 6.3% (95% CI: 0.4552-1.4808) prevalence of the underweight births during the second and third gestation trimesters, respectively. PM2.5 and CO did not demonstrate significant impacts on birthweight, although CO seemed to impair the birthweight outcomes, especially the exposure during the last trimester of pregnancy. The findings of this study have important public health implications that aim to protect health in its early development.
Detecting Weligama Coconut Leaf Wilt Disease in Coconut Using UAV-Based Multispectral Imaging and Object-Based Classification
Authors:   H.D.M.U Wijesinghe1 H.D.M.U Wijesinghe1, Tahrupath KMC , GUTTILA JAYASINGHE 
Published: February 2025

Abstract

Weligama Coconut Leaf Wilt Disease (WCLWD), a major threat to the coconut industry in Sri Lanka, has resulted in large economic losses (reduced productivity and high mortality rate) among infected palm. Early diagnosis is challenging and unreliable due to the low sensitivity of conventional disease detection methods like visual inspections and laboratory testing. In order to overcome these constraints, this study used object-based image analysis (OBIA) in combined with multispectral imaging using an unmanned aerial vehicle (UAV) to identify and categorize WCLWD in coconut palms. To differentiate between healthy and infected trees, Support Vector Machine (SVM) classification was used to analyze UAV images taken in five spectral bands: red, green, blue, red edge, and near infrared. The four band combination of 'blue', 'green', 'red-edge' and 'near infrared' was found to be the best of those tested, with an accuracy of 79.25% and a moderate agreement, based on the kappa coefficient of 0.493. The accuracy of this was then validated against a field survey ground truth data. Results show that overland biomass detection using OBIA methods with UAV multispectral imaging offers a feasible means to identify WCLWD, but that further classifier work and extra sources of data can improve accuracy. Results show the possibility of advanced remote sensing technologies for improve the detection of coconut WCLWD and support for managing the spread of disease in coconut plantations.