bluuebunny/crossref_metadata_2025_split huggingface dataset:
Religious Freedom and Sacred Lands
Authors: Sikka Sonia 
Published: December 2023

AbstractTaking Ktunaxa Nation v. British Columbia as a focal point, the author argues that the legal framing of Indigenous sacred land claims in terms of religious freedom carries significant costs. It impels courts to bracket consideration of sovereignty and territorial rights, while positioning Indigenous worldviews as nonrational rather than as dynamic intellectual traditions and ways of life that are respectably different from those embodied in settler systems of law. Genuinely fair adjudication of such claims requires not religious exemptions from general laws but recognition of the sui generis rights of Indigenous nations in relation to lands they never ceded (acknowledging historical injustice); deep differences between dominant European settler and Indigenous cultures (acknowledging that settler law is also cultural); and the validity of Indigenous environmental philosophies (acknowledging that they are no less rational than Western ones).
Embedded and exterior practices of cross-sector co-production: the impact of fields
Authors: Henriksen Lars Skov , Grubb Ane , Frederiksen Morten 
Published: December 2023

Abstract
Cross-sector co-production involving voluntary organisations in the production and delivery of social services has been adopted across many welfare states. Economic and demographic changes have led to increased involvement of volunteer initiatives in different welfare policy fields. How different field properties enable, constrain, and shape co-production practices remains, however, under researched. In this article, we address this shortcoming in a comparative case design exploring the practices of co-production within the two fields of elderly services and refugee services. We develop a conceptual framework and demonstrate that differential distribution of resources leads to diverging outcomes and perspectives for co-production. Based on a two-year in-depth study of one large Danish municipality, we find two forms of co-production practices, which reflect different field conditions. In the field of elderly services, co-production takes the form of ‘embedded’ practices, and in the field of refugee services co-production takes the form of ‘exterior’ practices. We demonstrate that each of these co-production forms entail ambiguous outcomes and antagonistic positions for voluntary and public sector actors, depending on the policy field.
Expert consensus on digital guided therapy for endodontic diseases
Authors: Wei Xi , Du Yu , Zhou Xuedong , Yue Lin , Yu Qing , Hou Benxiang , Chen Zhi , Liang Jingping , Chen Wenxia , Qiu Lihong , Huang Xiangya , Meng Liuyan , Huang Dingming , Wang Xiaoyan , Tian Yu , Tang Zisheng , Zhang Qi , Miao Leiying , Zhao Jin , Yang Deqin , Yang Jian , Ling Junqi 
Published: December 2023

AbstractDigital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades. The concept of DGT for endodontic diseases is categorized into static guided endodontics (SGE), necessitating a meticulously designed template, and dynamic guided endodontics (DGE), which utilizes an optical triangulation tracking system. Based on cone-beam computed tomography (CBCT) images superimposed with or without oral scan (OS) data, a virtual template is crafted through software and subsequently translated into a 3-dimensional (3D) printing for SGE, while the system guides the drilling path with a real-time navigation in DGE. DGT was reported to resolve a series of challenging endodontic cases, including teeth with pulp obliteration, teeth with anatomical abnormalities, teeth requiring retreatment, posterior teeth needing endodontic microsurgery, and tooth autotransplantation. Case reports and basic researches all demonstrate that DGT stand as a precise, time-saving, and minimally invasive approach in contrast to conventional freehand method. This expert consensus mainly introduces the case selection, general workflow, evaluation, and impact factor of DGT, which could provide an alternative working strategy in endodontic treatment.
Submonolayer biolasers for ultrasensitive biomarker detection
Authors: Gong Chaoyang , Yang Xi , Tang Shui-Jing , Zhang Qian-Qian , Wang Yanqiong , Liu Yi-Ling , Chen Yu-Cheng , Peng Gang-Ding , Fan Xudong , Xiao Yun-Feng , Rao Yun-Jiang , Gong Yuan 
Published: December 2023

AbstractBiomarker detection is key to identifying health risks. However, designing sensitive and single-use biosensors for early diagnosis remains a major challenge. Here, we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors. Telecom optical fibers serve as distributed optical microcavities with high Q-factor, great repeatability, and ultralow cost, which enables whispering-gallery laser emission to detect biomarkers. It is found that the sensing performance strongly depends on the number of gain molecules. The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection (LOD) when compared to saturated monolayer lasers. We further achieve an ultrasensitive immunoassay for a Parkinson’s disease biomarker, alpha-synuclein (α-syn), with a lower LOD of 0.32 pM in serum, which is three orders of magnitude lower than the α-syn concentration in the serum of Parkinson’s disease patients. Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.
Non-coding RNAs expression in SARS-CoV-2 infection: Pathogenesis, clinical significance and therapeutic targets
Authors: Liu Xiaoxing , Xiong Wandi , Ye Maosen , Lu Tangsheng , Yuan Kai , Chang Suhua , Han Ying , Wang Yongxiang , Lu Lin , Bao Yanping 
Published: December 2023

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has been looming globally for three years, yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration, which holds paramount importance in mitigating future epidemics. Host non-coding RNAs (ncRNAs) display aberrations in the context of COVID-19. Specifically, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) exhibit a close association with viral infection and disease progression. In this comprehensive review, an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development, encompassing viral invasion, replication, immune response, and multiorgan deficits which include respiratory system, cardiac system, central nervous system, peripheral nervous system as well as long COVID. Furthermore, we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19, such as stratification biomarkers, prognostic biomarkers, and predictive biomarkers for treatment response. In addition, we also discuss the therapeutic potential of ncRNAs for COVID-19, presenting ncRNA-based strategies to facilitate the development of novel treatments. Through an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis, we hope to offer valuable insights into the stratification, prognosis, and treatment of COVID-19.
Epithelial ovarian cancer survival by race and ethnicity in an equal-access healthcare population
Authors: Arter Zhaohui L. , Desmond Daniel , Berenberg Jeffrey L. , Killeen Jeffrey L. , Bunch Kristen , Merritt Melissa A. 
Published: December 2023

Abstract
Background
Previous studies in the general population observed that compared with non-Hispanic White women, Pacific Islander and Black women have higher age-adjusted mortality rates from epithelial ovarian cancer (EOC), while Asian American patients have lower mortality. We investigated whether race and ethnicity is associated with differences in EOC survival in a United States Military population where patients have equal access to healthcare.

Methods
This retrospective study included women diagnosed with EOC between 2001 and 2018 among Department of Defense beneficiaries. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models adjusting for age and year of diagnosis, histology and stage.

Results
In our study population of 1230 invasive EOC cases (558 non-Hispanic White, 74 non-Hispanic Black, 73 Asian, 30 Pacific Islander and 36 Hispanic cases), 63% of the women died (all-cause death) after a mean = 4.8 years (SD = 4.1) of follow-up following diagnosis. Compared with non-Hispanic White cases, Asian cases had better overall survival, HR = 0.76 (95% CI = 0.58–0.98), whereas there were no differences in survival for other racial and ethnic groups.

Conclusions
These findings highlight the need to investigate how differences in access to healthcare may influence observed racial and ethnic disparities for EOC.
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
Authors: Pan Yi-Ru , Lai Joseph Chieh-Yu , Huang Wen-Kuan , Peng Pei-Hua , Jung Shih-Ming , Lin Sheng-Hsuan , Chen Chiao-Ping , Wu Chiao-En , Hung Tsai-Hsien , Yu Alice L. , Wu Kou-Juey , Yeh Chun-Nan 
Published: December 2023

AbstractIntrahepatic cholangiocarcinoma (iCCA) is a subtype of CCA and has a high mortality rate and a relatively poor prognosis. However, studies focusing on increased cell motility and loss of epithelial integrity during iCCA progression remain relatively scarce. We collected seven fresh tumor samples from four patients to perform RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin using sequencing (ATAC-seq) to determine the transcriptome profile and chromatin accessibility of iCCA. The increased expression of cell cycle regulators, including PLK1 and its substrate MISP, was identified. Ninety-one iCCA patients were used to validate the clinical significance of PLK1 and MISP. The upregulation of PLK1 and MISP was determined in iCCA tissues. Increased expression of PLK1 and MISP was significantly correlated with tumor number, N stage, and lymphatic invasion in an iCCA cohort. Knockdown of PLK1 or MISP reduced trans-lymphatic endothelial migration and wound healing and affected focal adhesions in vitro. In cell‒cell junctions, MISP localized to adherens junctions and suppressed E-cadherin dimerization. PLK1 disrupted adherens junctions in a myosin-dependent manner. Furthermore, PLK1 and MISP promoted cell proliferation in vitro and tumorigenesis in vivo. In iCCA, PLK1 and MISP promote aggressiveness by increasing lymphatic invasion, tumor growth, and motility through the repression of E-cadherin adherens junctions.
Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells
Authors: Vogt Melina , Dienstbier Niklas , Schliehe-Diecks Julian , Scharov Katerina , Tu Jia-Wey , Gebing Philip , Hogenkamp Julian , Bilen Berna-Selin , Furlan Silke , Picard Daniel , Remke Marc , Yasin Layal , Bickel David , Kalia Munishikha , Iacoangeli Alfredo , Lenz Thomas , Stühler Kai , Pandyra Aleksandra A. , Hauer Julia , Fischer Ute , Wagener Rabea , Borkhardt Arndt , Bhatia Sanil 
Published: December 2023

AbstractHSP90 has emerged as an appealing anti-cancer target. However, HSP90 inhibitors (HSP90i) are characterized by limited clinical utility, primarily due to the resistance acquisition via heat shock response (HSR) induction. Understanding the roles of abundantly expressed cytosolic HSP90 isoforms (α and β) in sustaining malignant cells’ growth and the mechanisms of resistance to HSP90i is crucial for exploiting their clinical potential. Utilizing multi-omics approaches, we identified that ablation of the HSP90β isoform induces the overexpression of HSP90α and extracellular-secreted HSP90α (eHSP90α). Notably, we found that the absence of HSP90α causes downregulation of PTPRC (or CD45) expression and restricts in vivo growth of BCR-ABL1+ leukemia cells. Subsequently, chronic long-term exposure to the clinically advanced HSP90i PU-H71 (Zelavespib) led to copy number gain and mutation (p.S164F) of the HSP90AA1 gene, and HSP90α overexpression. In contrast, acquired resistance toward other tested HSP90i (Tanespimycin and Coumermycin A1) was attained by MDR1 efflux pump overexpression. Remarkably, combined CDK7 and HSP90 inhibition display synergistic activity against therapy-resistant BCR-ABL1+ patient leukemia cells via blocking pro-survival HSR and HSP90α overexpression, providing a novel strategy to avoid the emergence of resistance against treatment with HSP90i alone.
Inhibiting stromal Class I HDACs curbs pancreatic cancer progression
Authors: Liang Gaoyang , Oh Tae Gyu , Hah Nasun , Tiriac Hervé , Shi Yu , Truitt Morgan L. , Antal Corina E. , Atkins Annette R. , Li Yuwenbin , Fraser Cory , Ng Serina , Pinto Antonio F. M. , Nelson Dylan C. , Estepa Gabriela , Bashi Senada , Banayo Ester , Dai Yang , Liddle Christopher , Yu Ruth T. , Hunter Tony , Engle Dannielle D. , Han Haiyong , Von Hoff Daniel D. , Downes Michael , Evans Ronald M. 
Published: December 2023

AbstractOncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key epigenetic factors facilitating the induction of pro-desmoplastic and pro-tumorigenic transcriptional programs in pancreatic stromal fibroblasts. Mechanistically, HDAC-mediated changes in chromatin architecture enable the activation of pro-desmoplastic programs directed by serum response factor (SRF) and forkhead box M1 (FOXM1). HDACs also coordinate fibroblast pro-inflammatory programs inducing leukemia inhibitory factor (LIF) expression, supporting paracrine pro-tumorigenic crosstalk. HDAC depletion in cancer-associated fibroblasts (CAFs) and treatment with the HDAC inhibitor entinostat (Ent) in PDAC mouse models reduce stromal activation and curb tumor progression. Notably, HDAC inhibition (HDACi) enriches a lipogenic fibroblast subpopulation, a potential precursor for myofibroblasts in the PDAC stroma. Overall, our study reveals the stromal targeting potential of HDACi, highlighting the utility of this epigenetic modulating approach in PDAC therapeutics.
Selective synthesis of tightly- and loosely-twisted metallomacrocycle isomers towards precise control of helicity inversion motion
Authors: Nakajima Tomoki , Tashiro Shohei , Ehara Masahiro , Shionoya Mitsuhiko 
Published: December 2023

AbstractMolecular twist is a characteristic component of molecular machines. Selectively synthesising isomers with different modes of twisting and controlling their motion such as helicity inversion is an essential challenge for achieving more advanced molecular systems. Here we report a strategy to control the inversion kinetics: the kinetically selective synthesis of tightly- and loosely-twisted isomers of a trinuclear PdII-macrocycle and their markedly different molecular behaviours. The loosely-twisted isomers smoothly invert between (P)- and (M)-helicity at a rate of 3.31 s–1, while the helicity inversion of the tightly-twisted isomers is undetectable but rather relaxes to the loosely-twisted isomers. This critical difference between these two isomers is explained by the presence or absence of an absolute configuration inversion of the nitrogen atoms of the macrocyclic amine ligand. Strategies to control the helicity inversion and structural loosening motions by the mode of twisting offer future possibilities for the design of molecular machines.
Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin
Authors: Hibi Genki , Shiraishi Taro , Umemura Tatsuki , Nemoto Kenji , Ogura Yusuke , Nishiyama Makoto , Kuzuyama Tomohisa 
Published: December 2023

AbstractType II polyketide synthases (PKSs) normally synthesize polycyclic aromatic compounds in nature, and the potential to elaborate further diverse skeletons was recently revealed by the discovery of a polyene subgroup. Here, we show a type II PKS machinery for the biosynthesis of a five-membered nonaromatic skeleton contained in the nonproteinogenic amino acid cispentacin and the plant toxin coronatine. We successfully produce cispentacin in a heterologous host and reconstruct its biosynthesis using seven recombinant proteins in vitro. Biochemical analyses of each protein reveal the unique enzymatic reactions, indicating that a heterodimer of type II PKS-like enzymes (AmcF–AmcG) catalyzes a single C2 elongation as well as a subsequent cyclization on the acyl carrier protein (AmcB) to form a key intermediate with a five-membered ring. The subsequent reactions, which are catalyzed by a collection of type II PKS-like enzymes, are also peculiar. This work further expands the definition of type II PKS and illuminates an unexplored genetic resource for natural products.
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
Authors: Zhou Weiyin , Fischer Anja , Ogwang Martin D. , Luo Wen , Kerchan Patrick , Reynolds Steven J. , Tenge Constance N. , Were Pamela A. , Kuremu Robert T. , Wekesa Walter N. , Masalu Nestory , Kawira Esther , Kinyera Tobias , Otim Isaac , Legason Ismail D. , Nabalende Hadijah , Ayers Leona W. , Bhatia Kishor , Goedert James J. , Gouveia Mateus H. , Cole Nathan , Hicks Belynda , Jones Kristine , Hummel Michael , Schlesner Mathias , Chagaluka George , Mutalima Nora , Borgstein Eric , Liomba George N. , Kamiza Steve , Mkandawire Nyengo , Mitambo Collins , Molyneux Elizabeth M. , Newton Robert , Glaser Selina , Kretzmer Helene , Manning Michelle , Hutchinson Amy , Hsing Ann W. , Tettey Yao , Adjei Andrew A. , Chanock Stephen J. , Siebert Reiner , Yeager Meredith , Prokunina-Olsson Ludmila , Machiela Mitchell J. , Mbulaiteye Sam M. 
Published: December 2023

AbstractIn high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10−11 and 3.74×10−2, respectively). Autosomal mosaic chromosomal alterations are detected in 14.0% of Ghanaian men and increase with age. Mosaic chromosomal alterations in Burkitt lymphoma cases include gains on chromosomes 1q and 8, the latter spanning MYC, while mosaic chromosomal alterations in Burkitt lymphoma-free children include copy-neutral loss of heterozygosity on chromosomes 10, 14, and 16. Our results highlight mosaic chromosomal alterations in sub-Saharan African populations as a promising area of research.
Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review
Authors: Zuccarelli Lucrezia , Baldassarre Giovanni , Winnard Andrew , Harris Katie M. , Weber Tobias , Green David A. , Petersen Lonnie G. , Kamine Tovy Haber , Roberts Lara , Kim David S. , Greaves Danielle K. , Arya Roopen , Laws Jonathan M. , Elias Antoine , Rittweger Jörn , Grassi Bruno , Goswami Nandu 
Published: December 2023

AbstractWhole-body vibration (WBV) and resistive vibration exercise (RVE) are utilized as countermeasures against bone loss, muscle wasting, and physical deconditioning. The safety of the interventions, in terms of the risk of inducing undesired blood clotting and venous thrombosis, is not clear. We therefore performed the present systematic review of the available scientific literature on the issue. The review was conducted following the guidelines by the Space Biomedicine Systematic Review Group, based on Cochrane review guidelines. The relevant context or environment of the studies was “ground-based environment”; space analogs or diseased conditions were not included. The search retrieved 801 studies; 77 articles were selected for further consideration after an initial screening. Thirty-three studies met the inclusion criteria. The main variables related to blood markers involved angiogenic and endothelial factors, fibrinolysis and coagulation markers, cytokine levels, inflammatory and plasma oxidative stress markers. Functional and hemodynamic markers involved blood pressure measurements, systemic vascular resistance, blood flow and microvascular and endothelial functions. The available evidence suggests neutral or potentially positive effects of short- and long-term interventions with WBV and RVE on variables related to blood coagulation, fibrinolysis, inflammatory status, oxidative stress, cardiovascular, microvascular and endothelial functions. No significant warning signs towards an increased risk of undesired clotting and venous thrombosis were identified. If confirmed by further studies, WBV and RVE could be part of the countermeasures aimed at preventing or attenuating the muscular and cardiovascular deconditioning associated with spaceflights, permanence on planetary habitats and ground-based simulations of microgravity.
Cell-based, cell-cultured, cell-cultivated, cultured, or cultivated. What is the best name for meat, poultry, and seafood made directly from the cells of animals?
Authors: Hallman William K. , Hallman William K. , Hallman Eileen E. 
Published: December 2023

AbstractTo be sold in the United States, meat, poultry, and seafood products made from cultured cells must be labeled with a “common or usual name” to help consumers understand what they are purchasing. The terms “Cultured,” “Cultivated,” “Cell-Cultured,” “Cell-Cultivated,” “Cell-Based” and a control (without a common or usual name) were tested using an online experiment. Two regulatory criteria were assessed: that the term distinguishes the novel products from conventional products, and appropriately signals allergenicity. Three consumer acceptance criteria were assessed: that the term is seen as appropriate, does not disparage the novel or conventional products, nor elicit perceptions that the products are unsafe, unhealthy, or not nutritious. Each term was shown on packages of frozen Beef Filets, Beef Burgers, Chicken Breasts, Chicken Burgers, Atlantic Salmon Fillets, and Salmon Burgers. A representative sample of 4385 Americans (18 + ) were randomly assigned to view a single product with a single term or the control. Consumers’ ability to distinguish tested terms from conventional products differed by product category. “Cultured” and “Cultivated” failed to adequately differentiate the novel products from “Wild-Caught and Farm-Raised” salmon products. “Cultivated” failed to differentiate the novel Beef Filet product from “Grass-Fed” Beef Filets. “Cell-Cultured,” “Cell-Cultivated,” and “Cell-Based” each signaled that the products were different from conventional products across the proteins, and signaled allergenicity, meeting the two key regulatory criteria. They were not significantly different on most consumer perception measures. However, “Cell-Cultured” may have slightly better consumer acceptance across the novel beef, chicken, and salmon products, recommending its universal adoption.