bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adatok a dunai hajómalmok régészetéhez
Authors: Tóth János Attila 
Published: November 2023

AbsztraktA tanulmány a Közép-Duna-medence hajómalmokkal kapcsolatba hozható hajómaradványait veszi sorra. A hajómalmokhoz kapcsolható legkorábbi leletanyag a 14. század második-harmadik évtizedére keltezhető, és jól illeszkedik az írásos források adataival. A kiterjesztett monoxyl technika egészen a 19. század elejéig megfigyelhető a malomhajók építészetében, amely egyrészt folyamatosságra utal a középkori és újkori magyarországi hajóépítészetben, másrészt anakronisztikus technológiai megoldás az európai (folyami és tavi) hajóépítészet fejlődésének tükrében, magyarázata a célszerűség, a rendelkezésre álló jó minőségű, nagy méretű tölgy rönkök elérhetőségében feltételezhető. Első ízben sikerült felmérni mesterségesen kialakított hajóteleltető medencét, a lelőhelytípus további kutatása jelentős eredményeket ígér, különösen az újonnan definiált „többcélúan hasznosított, különleges adottságú vízterületek” esetében.
Analytical and experimental shear evaluation of GFRP-reinforced concrete beams
Authors: Mistretta Fausto , Puppio Mario Lucio , Camata Guido , Nanni Antonio 
Published: November 2023

AbstractReinforced Concrete (RC) technology is advancing towards new frontiers enhancing its sustainability and durability through innovative materials. In particular, the application of Glass Fiber Reinforced Polymer (GFRP) bars, in lieu of steel reinforcement, shows excellent performance, especially in aggressive environments. Nevertheless, current international design guidelines and standards tend to be rather conservative, especially concerning shear reinforcement. This element hinders the technology’s competitiveness, not only in terms of material consumption but also in construction efficiency. This research aims to conduct an analytical comparison and experimental validation of the formulations found in some international standards pertaining to shear capacity in a specific case. The focus is on scenarios involving reduced shear reinforcement and cases where the number of stirrups falls below the minimum recommended by these standards. In the sample beam tests, two distinct flexural GFRP reinforcement ratios were employed to evaluate their influence on shear capacity, leading to diverse failure mechanisms: rupture of longitudinal GFRP bars and concrete crushing. The experimental results were used to compare the North American ACI, French AFGC, and Italian CNR shear capacity design approaches in the case of reduced transversal reinforced ratio. Analytical capacity expressions of the standards above are discussed with some remarks aiming at structural optimization.
2017-2023: state of the art of gene therapies in rare diseases in Europe: the dynamics of clinical R&D, new approved treatments and expected therapies in the pipelines
Authors: Gicquel Tristan , Cortial Lucas , Lutsyk Karyna , Forget Sylvain , Braun Serge , Boyer Pierre-Olivier , Laugel Vincent , Blin Olivier 
Published: November 2023

Aim: Gene therapies have been tested over the past three decades, and after a first market authorization in 2017, the field is starting to deliver. The study aims to analyze the current development dynamics of gene therapies for rare diseases using the GENOTRIAL database®, which gathers information on gene therapy clinical trials and studies conducted between 2017 and 2023 in Europe.
Methods: The study involved extracting and filtering clinical trial data from the EudraCT database. Trials with the keyword "Gene Therapy" were selected and filtered using the "Rare disease" filter. Manual verification was conducted to ensure that the selected trial only concerned gene therapy treatments authorized in Europe for rare diseases in phases I to III. A total of 300 European country-related clinical investigations representing a total of 93 European-specific clinical studies were included in the GENOTRIAL database. The trials were classified by development phases, temporal status, sponsors and investigating countries, rare diseases with their related therapeutic area, and approval regulatory information of the identified gene therapies.
Results: Analysis reveals that rare diseases present a promising area for gene therapy development. On average, eight rare disease gene therapy trials are launched each year in Europe. The main sponsors of European clinical trials of gene therapies for rare diseases are from US, followed by the United Kingdom and France. The United Kingdom conducts the highest number of investigations in Europe, followed by France, Italy, Spain, and Germany. Nutritional and metabolic diseases are the most represented therapeutic area, followed by rare oncology, blood and lymphatic diseases, and ocular diseases. The analysis identifies 73 gene therapy medical products covering 35 diseases at various stages of development, with 12 new therapies approved in recent years for 8 rare diseases, while 15 other gene therapies are at an advanced stage of phase III in their development plan for 11 other rare diseases.
Conclusion: Gene therapy has shown significant progress and potential in treating rare genetic diseases. Europe has emerged as a promising region for gene therapy clinical trials in rare diseases. Efforts are now required to catch up with the USA and UK regarding the number of clinical trials sponsored by European groups.
Mesozoic-Cenozoic Exhumation Processes of the Harlik Mountain (East Tianshan), NW China: Evidence from Apatite (U-Th)/He Thermochronology
Authors: Zhang Bin , Yang Jing , Yang Li , Chen Hong , Liu Jiaqi , Wang Fei , Wu Lin 
Published: November 2023

Abstract
The Tianshan Mountains, which formed through the prolonged and complex subduction-accretion of the paleo-Asian ocean, experienced multiple widespread erosions and reactivations during the Mesozoic-Cenozoic period. Thus, the Tianshan has become a crucial area to explore the process and mechanism of intracontinental orogeny. The Harlik Mountain located in the easternmost part of Tianshan has special significance in revealing crustal deformation and far-field stress propagation. In this study, we use the apatite (U-Th)/He method to investigate the near-surface exhumation process of Harlik Mountain, which is the result of tectonic events and erosion. The apatite (U-Th)/He data and thermal history modeling reveal three enhanced exhumation events in the Harlik Mountain, i.e., the early Cretaceous, the late Cretaceous-Paleocene, and the middle Eocene. These events are consistent with the exhumation patterns observed throughout the entire Tianshan. Notably, the exhumation rate and amplitude in the early Cenozoic period were significantly higher in the Harlik Mountain compared with the Mesozoic period. Our findings reveal that the exhumation of the Harlik Mountain and the entire Tianshan displayed pronounced spatial-temporal variations throughout the Mesozoic-Cenozoic period. These variations can be attributed to the combined effect of uneven northward compression of the southern Asian margin, the heterogeneous rheological properties of the lithosphere, and the complex structure of the Tianshan.
Residents’ perceptions of the pedagogical preparation of preceptors in the Brazilian Unified Health System (BUHS) and associated factors
Authors: Silva Caroline Altes Moraes da , Rutkoski Audrey Oliveira , Oliveira Diógenes Dias , Figueiredo Maria Renita Burg , Bavaresco Caren Serra , Hernandez Pedro Antonio Gonzales , de Moura Flávio Renato Reis 
Published: November 2023

Abstract

Preceptors are workers in the Brazilian Unified Health System (SUS) and perform the function of mediators of teaching in service to graduate students. This research study examines the residents’ perceptions of the pedagogical preparation of preceptors in the SUS and associated factors. We conducted a cross-sectional study with data collected via an online self-report questionnaire. Poisson regression with robust variance was used in multivariate analysis. Of 151 residents, 59 (39.1%) considered the preceptor to be pedagogically prepared (PPP). Recognizing the preceptor as an important actor for establishing the connection between theoretical knowledge and practice (vs unimportant) and the preceptor holding meetings for planning, monitoring, and evaluation of the proposed actions during the teaching-learning process (vs not holding) increased by 41% (PR 1.41; 95% CI, 1.33–1.50) and 33% (PR 1.33; 95% CI, 1.20–1.47), respectively, the likelihood of residents considering the PPP. Performing activities to manage the work process in the primary health care unit and implementing an intervention project in the unit under the supervision of preceptors increased by 18% (PR 1.18; 95% CI, 1.05–1.32) and 13% (PR 1.13; 95% CI, 1.01–1.27), respectively, the likelihood of residents considering the PPP compared with not performing the proposed activities. These findings are essential to align interprofessional education with education guidelines and public health policies in Brazil. Also, our results can provide useful information for the development of pedagogical guidelines for Multiprofessional Residency Programs in Brazil and in other low- and middle-income countries.
Duskward displacement of plasmoids and reconnection in the magnetotail
Authors: Ieda Akimasa , Miyashita Yukinaga 
Published: November 2023

Abstract

Magnetic reconnection in the near-Earth magnetotail is responsible for explosive releases of energy during auroral breakups. This near-tail reconnection was previously assumed to occur around the midnight meridian, where earthward flows were observed. The Geotail spacecraft mission discovered that the reconnection location was displaced toward dusk, based on observations of tailward-moving plasmoids. This dusk preference is possibly caused by the Hall electric field, as was suggested in recent simulations. However, recent spacecraft observations suggested that the reconnection was displaced towards dawn, not dusk, in Mercury’s magnetotail. The reason for the difference between Earth and Mercury remains unclear. This study reinterprets and integrates previous statistical results on the dawn–dusk location of fast plasma flows in the near-Earth magnetotail to address the controversy surrounding the dawn–dusk displacement of reconnection location. Consequently, we confirmed that dusk preference is generally evident for tailward-moving structures but found that location preference is variable between studies of earthward-moving structures. These results indicate that the statistical results of earthward flows are sensitive to event selection criteria. We conclude that the dawn–dusk location of earthward flow is statistically unclear at the time of substorm onset. Accordingly, reconnection does not necessarily occur on the meridian where planetward-moving structures are observed. Tailward-moving plasmoids and reconnection may be predominantly located on the dusk side also in the Mercury’s magnetotail.
Application of Fuzzy - NSGA-II for achieving maximum biodiesel yield from waste cooking oil
Authors: Kavalli Kiran , Hebbar Gurumoorthy S , Rout Amruta 
Published: November 2023

Abstract

The main objective of this study was to optimize the parameters necessary for biodiesel production from waste cooking oil (WCO) using fuzzy modeling and Non-Dominated Sorting Genetic Algorithm-II (NSGA-II). To establish the relationship between input parameters (methanol, temperature, reaction time, and catalyst concentration) and the output (biodiesel yield), a fuzzy inference system was utilized. The input variables were normalized and represented by linguistic variables such as "small," "moderate," and "large," while the biodiesel yield was expressed in linguistic variables such as "small," "moderate," "moderately large," and "large." The defuzzification process was employed to obtain crisp values of the predicted output using the Centre of Gravity method, resulting in a mathematical model. This mathematical model was then used as an input function in NSGA-II to determine the optimal input process variables. NSGA-II was selected as it is a versatile and efficient metaheuristic algorithm that incorporates non-dominated sorting, accelerated strategies, and does not require sharing parameters. The developed model exhibited a high R square value of 96.34%, indicating a strong relationship between the input and output variables. The optimal transesterification process for biodiesel production from WCO was determined to be a methanol quantity of 150ml, reaction temperature of 62°C, reaction time of 63 minutes, and catalyst concentration of 7.5 grams. This optimized process yielded a conversion efficiency of 97.36%. Additionally, further experimentation was conducted using the Box-Behnken experimental design method to explore a wider range of input combinations. The maximum combination of input variables resulted in a biodiesel yield of 96.88%. Both the predicted and experimental biodiesel yields met the ASTM standard, with a conversion efficiency exceeding 96.5%. Overall, this study successfully optimized the biodiesel production process from waste cooking oil by employing fuzzy modeling and NSGA-II, leading to high conversion efficiencies and meeting industry standards.
Evaluation of risk factors for thrombosis after ultrasound-guided internal jugular vein catheterization in patients with lymphoma
Authors: Cao Kunpeng , Wang Xinyue , Wu Liuxi , Deng Hongyan , Xu Chaoli , Li Lu , Ye XinHua 
Published: November 2023

Abstract

We conducted a retrospective analysis of clinical and ultrasound data from 112 lymphoma patients who underwent ultrasound-guided internal jugular vein catheterization to investigate the risk factors for venous thrombosis. The procedure, which is safe and convenient for long-term chemotherapy, can be compromised by the development of venous thrombosis, impacting patient quality of life. Patients were divided into two groups: those with thrombosis (thrombus group) and those without (no thrombus group), based on preoperative vascular ultrasound findings within the internal jugular vein. In the multiple logistic regression analysis models, the catheter diameter (OR=0.145, 95%CI: 0.032-0.660, P<0.05), FIB (OR=2.438, 95%CI: 1.306-4.552, P<0.05), and diabetes (OR=0.139, 95%CI: 0.026-0.754, P<0.05) were found to have independent associations with thrombosis in lymphoma patients who underwent ultrasound-guided internal jugular vein catheterization (all P<0.05). The area under the curve was 0.816, indicating good predictive accuracy of the nomogram model for assessing the risk of thrombosis.
Temporal dynamics of wheat blast caused by Pyricularia oryzae Triticum lineage throughout the successive wheat cycles
Authors: Dorigan Adriano Francis , Pozza Edson Ampélio , Pereira Renata Cristina Martins , Moreira Silvino Intra , Ceresini Paulo Cezar , Silva Humberson Rocha , Alves Eduardo 
Published: November 2023

Abstract

Wheat blast, caused by Pyricularia oryzae Triticum lineage (PoTl), can infect wheat leaves and heads. The pathogen biology and disease epidemiology of the isolates PoTl still need more profound insights for the integrated management of wheat blast in Brazilian wheat fields. This study aimed to characterize the incubation period, latent period, and the temporal progress of wheat blast and to fit the best nonlinear model, describing the nature of an epidemic of the PoTl isolate 12.1.146 compared with the PoTl isolate Py6038, throughout five successive infection cycles of PoTl on wheat leaves and heads. Wheat blast occurred in all infection cycles. The incubation period and latent period of the PoTl isolate 12.1.146 were significantly shorter than that of the PoTl isolate Py6038. The secondary inocula produced by the PoTl isolates on symptomatic wheat leaves caused blast symptoms when inoculated on wheat heads. The area under the disease progress curve (AUDPC) was calculated based on disease severity. In all infection cycles, the AUDPC of the PoTl isolate 12.1.146 was significantly higher than that of the PoTl isolate Py6038. The nonlinear logistic model had the best fit to describe the intensity of the disease progress curves (DPCs) of PoTl isolates on wheat leaves and heads, fitting classic sigmoid-shaped curves. Our findings show that the disease severity of the PoTl isolate 12.1.146 did not reduce under grow chamber conditions, even after five successive infection cycles. These findings may imply the integrated management of the disease wheat blast pathogen in Brazilian fields.
A precision medicine approach to coronary artery disease risk prediction and mitigation in people with type 2 diabetes
Authors: Franks Paul , Coral Daniel , Fernández-Tajes Juan , Pigeyre Marie , Chong Michael , Atabaki-Pasdar Naeimeh , Fitipaldi Hugo , Kalamajski Sebastian , Gomez Maria , Paré Guillaume , Giordano Giuseppe , Pearson Ewan 
Published: November 2023

Abstract
Type 2 diabetes (T2D) predisposes to cardiovascular disease (CVD), but it is still unclear why some individuals with T2D are at disproportionately higher or lower risk. In this study, we employed a genetic stratification method to investigate the main clinical features that differ between two diabetogenic profiles associated concordantly with susceptibility for CVD or discordantly with protection against CVD. Quantifying concordant and discordant genetic predispositions improved CVD risk prediction, especially in men, correctly reassigning higher predicted risk to 5.4% of new male cases of MACE in UK Biobank. Moreover, higher genetically determined discordance reduced the risk associated with MACE in men. In-depth comparisons across a wide spectrum of phenotypes uncovered significant disparities between these two profiles. Subsequent causal inference analyses highlighted critical features of very-low-density lipoprotein particles influencing the discordance between T2D and CVD. We prioritized 8 distinct discordant genomic loci with potential protective effects traits against CVD in individuals with T2D. These findings provide clinically relevant valuable insights for personalized approaches to prevent and treat CVD in individuals with T2D.
How Intercity Expressway Passenger Flow Varies? A View from Month, City Characteristics, and Weather at the Origin and Destination
Authors: Li Xiaowei , Shi Lanxin , Wu Chenyang 
Published: November 2023

Abstract
This study aims to investigate the impact factors on intercity expressway passenger flow in China. A large-scale data set that integrated multiple data sources, including intercity passenger flow, city characteristics, and weather data, were constructed. To effectively handle and identify hidden patterns in the large-scale data, we employed Explainable Artificial Intelligence (XAI) models to analyze the associations between the impact factors and the intercity expressway passenger flow. The results show that among the XAI models used, the Explainable Extra Tree model that utilized SHAP (SHapley Additive exPlanations) values to explain the contributions of impact factors outperforms all others. In terms of the impact factors, we find that the intercity expressway passenger flow increased remarkably during certain months (such as February and September). In addition to city characteristics and weather variables that have been investigated by previous studies (e.g., GDP and temperature), the male-female ratio, the city tiers, and the temperature at the origin and destination cities were also found to be important contributors to expressway passenger flow. This study contributes to a deeper understanding of intercity expressway passenger flow patterns, offering valuable insights to policymakers for more effective management of intercity expressway passenger transportation.
Potential Role of Peripheral Blood Lymphocyte Subsets in Rheumatoid Arthritis Patients Concurrent with Hepatitis B Virus Infection：A Retrospective Cohort Study
Authors: Lijia Shao , Shuo Zhao , Shengchun Feng , Yongjun Ma , Lihong Shen 
Published: November 2023

Abstract

Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Previous studies have shown that RA patients have high HBV infection rates. Hepatitis B virus (HBV) infection has a deleterious effect on the radiographic and clinical outcomes of patients with RA. This study investigated the composition of peripheral blood lymphocytes in patients with RA and concurrent HBV infection. Identifying peripheral blood lymphocyte subsets could provide insights into their deleterious effects on clinical outcomes among these patients. Methods To investigate the composition of peripheral blood lymphocytes in patients with RA or RA with concurrent HBV infection, 298 patients were recruited from a prospective cohort of patients with RA. Based on the HBV infection status, 43 patients with RA and concurrent HBV infection were assigned to the HBV group (HBV-RA group), while 255 patients without HBV infection were assigned to the control group. Patients in the HBV-RA group were split into groups with HBV DNA levels below the lower limit of quantification (< 20 IU/ml, HBV DNAlowgroup) and above the lower limit of quantification (≥ 20 IU/ml, HBV DNAhighgroup). Demographic, clinical, and laboratory data were also collected. Results Compared with those of the control group, a higher percentage of CD19+B cells and CD8+T cells and a lower CD4+/CD8+ratio were observed in the HBV-RA group (allP < 0.05). The same trend was observed in the HBV DNAhighgroup compared to the HBV DNAlowgroup (allP < 0.05). In addition, according to multivariable logistic regression analysis, male sex, DAS-28 ≥ 2.6, and a high proportion of CD19+B and CD8+T cells were unfavorable factors for HBV-infected RA (allP < 0.05). Conclusion The composition of peripheral blood lymphocytes in patients with RA and concurrent HBV infection differs from that of patients with RA without HBV infection. Male sex, DAS-28 ≥ 2.6, the high proportion of CD19+B and CD8+T cells were unfavorable factors for RA concurrent with HBV infection; therefore, these factors warrant greater clinical attention.
Optimizing SH-SY5Y Cell Culture: Exploring the Beneficial Effects of an Alternative Media Supplement on Cell Proliferation and Viability
Authors: Kaya Zeynep Bengisu , Santiago-Padilla Valeria , Lim Melina , Boschen Suelen L. , Atilla Pergin , McLean Pamela J. 
Published: November 2023

Abstract
In the quest to unravel the mysteries of neurological diseases, comprehending the underlying mechanisms is supreme. The SH-SY5Y human neuroblastoma cell line serves as a crucial tool in this endeavor; however, the cells are known for its sensitivity and slow proliferation rates. Typically, this cell line is cultured with 10% Fetal Bovine Serum (FBS) supplement. Nu-Serum (NuS), a low-protein alternative to FBS, is promising to advance cell culture practices. Herein, we evaluated the substitution of NuS for FBS to test the hypothesis that an alternative serum supplement can aid and promote SH-SY5Y cell proliferation and differentiation. Our findings revealed that the NuS-supplemented group exhibited a notable increase in adhered cells compared to both the FBS and serum-free (SF) groups. Importantly, cell viability remained high in both sera treated groups, with the NuS-supplemented cells displaying significantly larger cell sizes compared to the SF-treated group. Furthermore, cell proliferation rates were higher in the NuS-treated group, and neuroblast-like morphology was observed earlier than FBS group. Notably, both FBS and NuS supported the differentiation of these cells into mature neurons. Our data supports NuS as an alternative for SH-SY5Y cell culture, with the potential to elevate the quality of research in the neuroscience field.