bluuebunny/crossref_metadata_2025_split huggingface dataset:
SilkMeta: a comprehensive platform for sharing and exploiting pan-genomic and multi-omic silkworm data
Authors: Lu Kunpeng , Pan Yifei , Shen Jianghong , Yang Lin , Zhan Chengyu , Liang Shubo , Tai Shuaishuai , Wan Linrong , Li Tian , Cheng Tingcai , Ma Bi , Pan Guoqing , He Ningjia , Lu Cheng , Westhof Eric , Xiang Zhonghuai , Han Min-Jin , Tong Xiaoling , Dai Fangyin 
Published: November 2023

Abstract
The silkworm Bombyx mori is a domesticated insect that serves as an animal model for research and agriculture. The silkworm super-pan-genome dataset, which we published last year, is a unique resource for the study of global genomic diversity and phenotype-genotype association. Here we present SilkMeta (http://silkmeta.org.cn), a comprehensive database covering the available silkworm pan-genome and multi-omics data. The database contains 1082 short-read genomes, 546 long-read assembled genomes, 1168 transcriptomes, 294 phenotype characterizations (phenome), tens of millions of variations (variome), 7253 long non-coding RNAs (lncRNAs), 18 717 full length transcripts and a set of population statistics. We have compiled publications on functional genomics research and genetic stock deciphering (mutant map). A range of bioinformatics tools is also provided for data visualization and retrieval. The large batch of omics data and tools were integrated in twelve functional modules that provide useful strategies and data for comparative and functional genomics research. The interactive bioinformatics platform SilkMeta will benefit not only the silkworm but also the insect biology communities.
TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
Authors: Zheng Jiaying , Wang Lingxiao , Zhao Shunyi , Zhang Wenjing , Chang Yuzhou , Bosco Dale B , Huang Tao , Dheer Aastha , Gao Shan , Xu Shengze , Ayasoufi Katayoun , Al-Kharboosh Rawan , Qi Fangfang , Xie Manling , Johnson Aaron J , Dong Haidong , Quiñones-Hinojosa Alfredo , Wu Long-Jun 
Published: November 2023

Abstract

Background
Myeloid cells comprise up to 50% of the total tumor mass in glioblastoma (GBM) and have been implicated in promoting tumor progression and immunosuppression. Modulating the response of myeloid cells to the tumor has emerged as a promising new approach for cancer treatment. In this regard, we focus on the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), which has recently emerged as a novel immune modulator in peripheral tumors.

Methods
We studied the TREM2 expression profile in various patient tumor samples and conducted single-cell transcriptomic analysis in both GBM patients and the GL261 mouse glioma model. We utilized multiple mouse glioma models and employed state-of-the-art techniques such as invivo 2-photon imaging, spectrum flow cytometry, and in vitro co-culture assays to study TREM2 function in myeloid cell-mediated phagocytosis of tumor cells, antigen presentation, and response of CD4+ T cells within the tumor hemispheres.

Results
Our research revealed significantly elevated levels of TREM2 expression in brain tumors compared to other types of tumors in patients. TREM2 was predominantly localized in tumor-associated myeloid cells and was highly expressed in nearly all microglia, as well as various subtypes of macrophages. Surprisingly, in preclinical glioma models, TREM2 deficiency did not confer a beneficial effect; instead, it accelerated glioma progression. Through detailed investigations, we determined that TREM2 deficiency impaired the ability of tumor-myeloid cells to phagocytose tumor cells and led to reduced expression of MHCII. This deficiency further significantly decreased the presence of CD4+ T cells within the tumor hemispheres.

Conclusions
Our study unveiled a previously unrecognized protective role of tumor-myeloid TREM2. Specifically, we found that TREM2 enhances the phagocytosis of tumor cells and promotes an immune response by facilitating MHCII-associated CD4+ T-cell responses against gliomas.
Chrononutrition and metabolic health in children and adolescents: a systematic review and meta-analysis
Authors: Fiore Giulia , Scapaticci Serena , Neri Costanza R , Azaryah Hatim , Escudero-Marín Mireia , Pascuzzi Martina C , La Mendola Alice , Mameli Chiara , Chiarelli Francesco , Campoy Cristina , Zuccotti Gianvincenzo , Verduci Elvira 
Published: November 2023

Abstract

Context
Obesity has emerged as a global health issue for the pediatric population, increasing the need to investigate physiopathological aspects to prevent the appearance of its cardiometabolic complications. Chrononutrition is a field of research in nutritional sciences that investigates the health impact of 3 different dimensions of feeding behavior: regularity of meals, frequency, and timing of food intake.

Objective
We carried out a systematic review and meta-analysis to investigate the association between chrononutrition in children and adolescents and the risk of overweight/obesity or a cluster of metabolic abnormalities related to glucose and lipid metabolism, blood pressure, and cardiovascular disease risk.

Data Extraction
A literature search was performed using PubMed, EMBASE, and The Cochrane Library for relevant articles published before August 2022.

Data Analysis
A total of 64 articles were included in the narrative synthesis (47 cross-sectional and 17 cohort studies), while 16 studies were included in the meta-analysis. Meta-analysis showed that non–daily breakfast consumers (≤6 d/wk) had a higher risk of overweight/obesity (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.08–1.82] compared with daily breakfast eaters (7 d/wk). Similarly, irregular breakfast consumption (only 0-to-3 times/wk) increased the risk of abdominal obesity (waist-to-height ratio ≥ 0.5) compared with regular consumption (5-to-7 times/wk) (OR, 1.38; 95% CI, 1.26–1.49). There was evidence to suggest that a regular frequency of meal consumption (≥4 times/d) is preventive against overweight/obesity development compared with fewer meals (≤3 times/d) (OR, 0.83; 95% CI, 0.70–0.97). In the narrative synthesis, snacking habits showed controversial results, while food timing was the most understudied dimension.

Conclusion
Overall, our data indicate a potential implication of chrononutrition in affecting pediatric metabolic health; however, the evidence of this association is limited and heterogeneous. Further prospective and intervention studies with a consistent approach to categorize the exposure are needed to elucidate the importance of chrononutrition for pediatric metabolic health.
Aftermath
Authors: Carrington Paul D 
Published: November 2023

Abstract
The attainments of so distinguished a scholar and legal theorist as Patrick Atiyah are not only his by reason of his own talents and efforts, but are also attainments of the legal tradition in which he writes and of the culture of which that tradition is part. This is, of course, no less true for the attainments of American legal and political theorists: theory is everywhere more outcome than cause of political and social institutions. Few readers are likely to dispute this assertion. Yet the point is at moments overlooked.
Three Problems with the New Product Liability
Authors: Stapleton Jane 
Published: November 2023

Abstract
In Accidents, Compensation and the Law, Patrick Atiyah wrote: ‘All the disabled are entitled to equal sympathy and equal support from the State and ad hoc treatment of special groups can only lead to the abandonment of all rationality in policy.,1 It was a double-barrelled broadside directed at the then-present system of compensation for personal injuries, both calling for government organization of compensation rather than the existing plethora of systems, and attacking tactics which, on no principled grounds, elevated certain subgroups of the disabled by granting them preferential treatment in either public or private law compensation systems. So withering were the attacks made by Atiyah and others on the systems of personal-injuries compensation that its comprehensive reform by government was widely thought proper and almost inevitable. For a number of reasons this was not to be. The principal subsequent legal reform in the area is Part 1 of the Consumer Protection Act 1987, the domestic adoption of the European Community’s 1985 Directive on Product Liability (‘the Directive’), which provides for a new, additional remedy for certain victims of injuries caused by certain products. This law offends both parts of Atiyah’s principle. First, in response to what were seen as unacceptable anomalies between the remedies of those in a contractual relationship with a member of the chain of commercial manufacture and supply of products and those not in such a relationship, it gave a new remedy to both these subgroups of personal-injuries victims, and in so doing simply shifted the location of the anomaly without a convincing justification. Secondly, the law offends the principle because it probably pre-empts comprehensive reorganization of personal-injury compensation by a reformist UK government. This discussion focuses on these and the other, more well-known, problem of the Directive, that of claims for defective design.
Regulation (Ec) 1383/2003
Authors: Schneider Marius , Vrins Olivier 
Published: November 2023

Abstract
Before we study in detail the provisions of Council Regulation (EC) 1383/2003 of 22 July 2003 concerning customs action against goods suspected of infringing certain intellectual property rights, and the measures to be taken against goods found to have infringed such rights(hereafter referred to as ‘the Regulation’) in the substantive sections of this book, we will look at the aims and objectives of the Regulation (section A), and the historical background of border measures in the European Community (section B).
Austria
Authors: Sonn Helmut 
Published: November 2023

Abstract
Prior to the entry into force of EC Regulation 1383/2003(‘the Regulation’), Austria had already adopted a law on counterfeiting.It was based on the second generation Regulation 3295/94,as amended in 1999.This old law already provided for the possibility of filing applications for action with customs. They were filed by a right-holder or his representative, and normally covered the whole trade mark and (if applicable) design portfolio valid in Austria of the respective right-holder.
Belgium
Authors: Vrins Olivier , Schneider Marius 
Published: November 2023

Abstract
Belgium is one of the founder members of the European Communities. The first Community Regulation on border measures 3842/86/EEC entered into force in the Kingdom on 1 January 1988. However, the system of border measures in Regulation 3842/86/EEC was hardly applied in Belgium, as the national legislator failed to appoint the competent authority within the meaning of Article 3 of this Regulation. As there was no designated authority for processing applications for border measures, the system was paralysed, with the exception of a few actions taken by particularly active public prosecutors.
Czech Republic
Authors: Korejzova Petra 
Published: November 2023

Abstract
Prior to the accession of the Czech Republic to the European Union on 1 May 2004, border measures applied by customs in the field of intellectual property were governed by the ‘Act on importation, exportation, and re-exportation of goods infringing certain intellectual property rights’ (Act on Custom Actions),which was already in accordance with European legal standards as laid down in Council Regulation 3295/94and Commission Regulation 1367/95.
Slovenia
Authors: Maček Gregor , Bukovnik Andrej 
Published: November 2023

Abstract
Prior to Slovenia’s entry into the European Union on 1 May 2004, border measures were regulated by the Customs Codeand the Law on Customs Measures Relating to Infringements of Intellectual Property Rights.Both pieces of legislation were in line with the acquis communautaire on border measures, and the Slovenian customs authorities enforced them effectively.
Spain
Authors: Larramendi Luis H , Elzaburu Ignacio Diez de Rivera 
Published: November 2023

Abstract
Spain joined the European Community in 1986 and applied the system of border measures set out by the European legislator since the entry into force of Community Regulation No 3842/86 on 1 January 1988.The border measures system in Spainhas from the very beginning been applied directly from EC Regulations 3842/86 and 3295/94.Border measures were applied timidly at first but the number of applications for action and effective actions by Spanish Customs and the efficacy of the Spanish customs authorities has gradually increased.
United Kingdom
Authors: Firth Alison , Phillips Jeremy 
Published: November 2023

Abstract
The United Kingdom has a long history of national measures to discourage the entry of infringing goods from abroad. Clarkcites an Act for General Regulation of Customs as long ago as 1845. The United Kingdom was a founder member of the Paris Convention for the Protection of Industrial Property of 1883. Since the Convention’s entry into force on 7 July 1884, therefore, the United Kingdom has had an international obligation to provide for seizure of imports bearing protected marks.
Evolution of the thermostability of actin-depolymerizing factors enhances the adaptation of pollen germination to high temperature
Authors: Qian Dong , Li Tian , Chen Shuyuan , Wan Dongshi , He Yongxing , Zheng Chen , Li Jiajing , Sun Zhenping , Li Jiejie , Sun Junxia , Niu Yingzhi , Li Hongxia , Wang Muxuan , Niu Yue , Yang Yang , An Lizhe , Xiang Yun 
Published: November 2023

AbstractDouble fertilization in many flowering plants (angiosperms) often occurs during the hot summer season, but the mechanisms that enable angiosperms to adapt specifically to high temperatures are largely unknown. The actin cytoskeleton is essential for pollen germination and the polarized growth of pollen tubes, yet how this process responds to high temperatures remains unclear. Here, we reveal that the high thermal stability of 11 Arabidopsis (Arabidopsis thaliana) actin-depolymerizing factors (ADFs) is significantly different: ADFs that specifically accumulate in tip-growing cells (pollen and root hairs) exhibit high thermal stability. Through ancestral protein reconstruction, we found that subclass II ADFs (expressed specifically in pollen) have undergone a dynamic wave-like evolution of the retention, loss, and regeneration of thermostable sites. Additionally, the sites of AtADF7 with high thermal stability are conserved in ADFs specific to angiosperm pollen. Moreover, the high thermal stability of ADFs is required to regulate actin dynamics and turnover at high temperatures to promote pollen germination. Collectively, these findings suggest strategies for the adaptation of sexual reproduction to high temperature in angiosperms at the cell biology level.
A missing jigsaw within the hygiene hypothesis: Low-dose bisphenol A exposure attenuates lipopolysaccharide-induced asthma protection
Authors: Wang Mengjing , Qu Jing , Yang Junjie , Zhang Tian , Tan Wei Ren , Liao Shumin , Chen Xing , Liu Yingzi , Long Xiang , Li Xue , Xia Yun , Tan Nguan Soon , Li Liang , Fang Mingliang 
Published: November 2023

Abstract
The rising occurrence of allergic asthma in early life across industrialized countries suggests that environmental factors play a crucial role in determining asthma susceptibility and severity. While prior exposure to microbial lipopolysaccharides (LPSs) has been found to offer protection against allergic asthma, infants residing in urban environments are increasingly exposed to environmental pollutants. Utilizing limulus lysate test screens and virtual screening models, we identified pollutants that can modulate LPS bioactivity. This investigation revealed that bisphenol A (BPA), a chemical commonly used in numerous household items and previously implicated in obesity and cancer, effectively neutralizes LPS. In-depth mechanistic analyses showed that BPA specifically binds to the lipid A component of LPS, leading to inactivation. This interaction eliminates the immunostimulatory activity of LPS, making mice more susceptible to house dust mite (HDM)-induced allergic asthma. BPA reactivates lung epithelial cells, consequently amplifying type 2 responses to HDMs in dendritic cells. This chemical interplay provides new insights into the pathophysiology of asthma in relation to human exposure. Understanding the intricate relationships between environmental chemicals and microbial antigens, as well as their impacts on innate immunity, is critical for the development of intervention strategies to address immune disorders resulting from urbanization.
Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ventilation
Authors: Dridi Haikel , Yehya Marc , Barsotti Robert , Liu Yang , Reiken Steven , Azria Lan , Yuan Qi , Bahlouli Laith , Soni Rajesh Kumar , Marks Andrew R , Lacampagne Alain , Matecki Stefan 
Published: November 2023

Abstract
In critical care patients, the “”temporary inactivity of the diaphragm caused by mechanical ventilation (MV) triggers a series of events leading to diaphragmatic dysfunction and atrophy, commonly known as ventilator-induced diaphragm dysfunction (VIDD). While mitochondrial dysfunction related to oxidative stress is recognized as a crucial factor in VIDD, the exact molecular mechanism remains poorly understood. In this study, we observe that 6 h of MV triggers aberrant mitochondrial dynamics, resulting in a reduction in mitochondrial size and interaction, associated with increased expression of dynamin-related protein 1 (DRP1). This effect can be prevented by P110, a molecule that inhibits the recruitment of DRP1 to the mitochondrial membrane. Furthermore, isolated mitochondria from the diaphragms of ventilated patients exhibited increased production of reactive oxygen species (ROS). These mitochondrial changes were associated with the rapid oxidation of type 1 ryanodine receptor (RyR1) and a decrease in the stabilizing subunit calstabin 1. Subsequently, we observed that the sarcoplasmic reticulum (SR) in the ventilated diaphragms showed increased calcium leakage and reduced contractile function. Importantly, the mitochondrial fission inhibitor P110 effectively prevented all of these alterations. Taken together, the results of our study illustrate that MV leads, in the diaphragm, to both mitochondrial fragmentation and dysfunction, linked to the up-/down-regulation of 320 proteins, as assessed through global comprehensive quantitative proteomics analysis, primarily associated with mitochondrial function. These outcomes underscore the significance of developing compounds aimed at modulating the balance between mitochondrial fission and fusion as potential interventions to mitigate VIDD in human patients.
Re-thinking learning and development and well-being in the policing of rape: Insights from a rapid review of comparable public-service occupations
Authors: Rawdin Clare 
Published: November 2023

Abstract
Research within Operation Soteria Bluestone (OSB) has highlighted a number of challenges within learning and development for officers who investigate rape and serious sexual offences (RASSO). Moreover, one neglected area has been the relationship between learning and development and officer well-being. This article is based on a rapid review of 3,673 English-language titles that aimed to examine ‘best practice’ learning and development in the RASSO field. Using a combination of electronic and hand-searching methods, 52 titles were identified and subject to a full-text review. Three broad themes were identified and highlight the importance of: (1) considering which specialist knowledge and skills to develop; (2) encouraging active and reflective learners; and (3) measuring the impact of learning and development. The findings suggest there is much to learn from comparable, public-service occupations which can usefully inform and shape the re-design of certain elements of specialist RASSO training.
Heart and systemic sclerosis—findings from a national cohort study
Authors: Guédon Alexis F , Carrat Fabrice , Mouthon Luc , Launay David , Chaigne Benjamin , Pugnet Grégory , Lega Jean-Christophe , Hot Arnaud , Cottin Vincent , Agard Christian , Allanore Yannick , Fauchais Anne-Laure , Jego Patrick , Dhote Robin , Papo Thomas , Chatelus Emmanuel , Bonnotte Bernard , Khan Jean-Emmanuel , Diot Elisabeth , Bienvenu Boris , Magy-Bertrand Nadine , Queyrel Viviane , Le Quellec Alain , Kieffer Pierre , Amoura Zahir , Harlé Jean-Robert , Gaultier Jean-Baptiste , Balquet Marie-Hélène , Wahl Denis , Lidove Olivier , Fain Olivier , Mékinian Arsène , Hachulla Eric , Rivière Sebastien 
Published: November 2023

Abstract

Objectives
Heart involvement is one of the leading causes of death in SSc. The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc.

Methods
We used data from a multicentric prospective study using the French SSc national database. Focusing on SSc-related cardiac involvement, we aimed to determine its incidence and risk factors.

Results
Of the 3528 patients with SSc, 312 (10.9%) had SSc-related cardiac involvement at baseline. They tended to have a diffuse SSc subtype more frequently and to have more severe clinical features, and presented more cardiovascular risk factors. From the 1646 patients available for follow-up analysis, SSc-related cardiac involvement was associated with an increased risk of death. There was no significant difference in overall survival between SSc-related cardiac involvement, ischaemic heart disease or pulmonary arterial hypertension. Regarding survival analysis, 98 patients developed SSc-related cardiac involvement at 5 years (5-year event rate 11.15%). Regarding reduced left ventricular ejection fraction &lt;50% and left ventricular diastolic dysfunction, the 5-year event rate was 2.49% and 5.84%, respectively. Pericarditis cumulative incidence at 5 years was 3%. Diffuse SSc subtype was a risk factor for SSc-related cardiac involvement and pericarditis. Female sex was associated with less left ventricular diastolic dysfunction incidence.

Conclusions
Our results describe the incidence and prognostic burden of SSc-related cardiac involvement at a large scale, with gender and diffuse SSc subtype as risk factors. Further analyses should assess the potential impact of treatment on these various cardiac outcomes.
Noise-induced sleep disruption from wind turbines: scientific updates and acoustical standards
Authors: Ellenbogen Jeffrey M , Kellam Colleen B , Hankard Michael 
Published: November 2023

Abstract
Wind energy appears to place global environmental benefits against local human health, particularly sleep. The result is a significant challenge to wind-energy development for the achievement of large-scale alternative energy. Our purpose is to examine noise from wind turbines and its potential to disrupt sleep, to examine the human health literature addressing these concerns, and to provide insight into how developers and communities can employ these concepts to pursue wind energy without impacting human health. The latest and most rigorous research on noise from wind turbines points to healthy sleep, when turbines are sited reasonably. This includes audible noise, low-frequency noise, and infrasound. Recent advances in acoustical standards provide practical methods to ensure adherence to these scientific findings. There now exist key data concerning wind-turbine noise, and its impact on sleep. Knowing that information, and how to deploy it with modern engineering standards should simultaneously facilitate wind development and protect human health.