bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal‐Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy
Authors: He Xianglian , Gong Guidong , Chen Mei , Zhang Haojie , Zhang Yajing , Richardson Joseph J. , Chan Wood Yee , He Yunxiang , Guo Junling 
Published: February 2024

AbstractDue to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet autologous tumor cell vaccines require multi‐step production that frequently leads to the loss of immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking cancer cells with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) to evoke tumor‐specific immune response for highly efficacious synergistic cancer immunotherapy. The natural polyphenols coordinate with Mn2+ and immediately adhere to the surface of individual cancer cells, thereby forming a nanocloak and encapsulating tumor neoantigens. Subsequent decoration with lipopolysaccharide induces internalization by dendritic cells, where Mn2+ ions are released in the cytosol, further facilitating the activation of the stimulator of the interferon genes (STING) pathway. Highly effective tumor suppression was observed by combining the nanocloaked cancer cell treatment with anti‐programmed cell death ligand 1 (anti‐PD‐L1) antibodies‐mediated immune checkpoint blockade therapy. Our work demonstrates a universal yet simple strategy to engineer a cell‐based nanobiohybrid system for enhanced cancer immunotherapy.
A Small‐Molecule Ratiometric Photoacoustic Probe for the High‐Spatiotemporal‐Resolution Imaging of Copper(II) Dynamics in the Mouse Brain
Authors: Jiang Zhiyong , Zhang Changli , Wang Xiaoqing , Ling Zongxin , Chen Yuncong , Guo Zijian , Liu Zhipeng 
Published: February 2024

AbstractCopper dysmetabolism is associated with various neurodegenerative disorders, making high‐spatiotemporal‐resolution imaging of Cu2+ in the brain essential for understanding the underlying pathophysiological processes. Nevertheless, the current probes encounter obstacles in crossing the blood–brain barrier (BBB) and providing high‐spatial‐resolution in deep tissues. Herein, we present a photoacoustic probe capable of imaging Cu2+ dynamics in the mouse brain with high‐spatiotemporal‐resolution. The probe demonstrates selective ratiometric and reversible responses to Cu2+, while also efficiently crossing the BBB. Using the probe as the imaging agent, we successfully visualized Cu2+ in the brain of Parkinson's disease (PD) model mouse with a remarkable micron‐level resolution. The imaging results revealed a significant increase in Cu2+ levels in the cerebral cortex as PD progresses, highlighting the close association between Cu2+ alternations in the region and the disease. We also demonstrated that the probe can be used to monitor changes in Cu2+ distribution in the PD model mouse brain during L‐dopa intervention. Mechanism studies suggest that the copper dyshomeostasis in the PD mouse brain was dominated by the expression levels of divalent metal transporter 1. The application of our probe in imaging Cu2+ dynamics in the mouse brain offers valuable insights into the copper‐related molecular mechanisms underlying neurodegenerative diseases.
Revealing the pyrolysis mechanism of polypropylene cable insulation: A combined study of TG‐GC experiments and RMD/DFT simulations
Authors: Guo Yifan , Wu Yunjian , Zhang Danfeng , Fang Rui , Zhang Xiaoxing 
Published: February 2024

AbstractStyrene grafted polypropylene (PP‐g‐St) is one of the insulating materials for high voltage power cables. However, the process of pyrolysis gas generation in polypropylene cable insulation remains poorly understood. To address this knowledge gap, this study employed a combination of thermogravimetric‐gas chromatography experiments, density functional theory, and reactive molecular dynamics simulations. The experimental findings revealed that the pyrolysis gases primarily consisted of H2, CO, C2H4, and CH4. Higher temperatures were found to increase the yields of H2 and CO. The simulation results indicated that H2 and CO were generated through the rupture of less reactive olefins and radicals, while C2H4 was primarily produced by the rupture of CC bonds in the polypropylene chain. Additionally, CH4 was formed when CH3 groups captured hydrogen from other molecules. By the chain reaction mechanism, we enable the calculation of the activation energy of PP‐g‐St. This study provides a theoretical foundation for understanding the pyrolysis gas generation.
Controlling the Potential of Affordable Quasi‐Solid Composite Gel Polymer Electrolytes for High‐Voltage Lithium‐Ion Batteries
Authors: Kumar Mishra Govind , Gautam Manoj , Bhawana K. , Patro Manisha , Kumar Singh Shishir , Mitra Sagar 
Published: February 2024

AbstractThis study focuses on the development of a composite gel polymer electrolyte membrane (CGPEM) as a solution to address safety concerns arising from the reactivity of lithium metal and the formation of dendrites. The CGPEM integrates a solid polymer matrix, solid‐electrolyte LSiPS (Li10SiP2S12), with a plasticizer that countering the performance decline caused by sulfide solid electrolyte (SSE) interactions with the cathode. Poly ethylene oxide (PEO) emerges as a promising polymer matrix due to its flexibility, cost‐effectiveness, eco‐friendliness, solvability for Li‐salt, mechanical processing adaptability, adhesive strength, and ionic conductivity. Conductivity and processability of CGPEM were optimized through meticulous adjustment of liquid plasticizer concentration. The CGPEM′s chemical and electrochemical stability were systematically investigated using in‐situ electrochemical impedance spectroscopy (EIS) and distribution of relaxation times (DRTs). A lithium metal battery is constructed against a high voltage cathode and newly developed CGPEM. Impressively, the cell exhibited outstanding performance, maintaining a discharge capacity of around 146.22 mAh/g after 200 cycles, retaining 86.38 % of its initial capacity. The formation of a LiF‐rich interface layer near the lithium surface, a vital element in curbing CGPE degradation and dendritic growth, resulted in enhanced overall cell performance.
Risk factors of bladder stones in neurogenic lower urinary tract dysfunction: A real‐world study
Authors: Möhr Sandra , Fassbind Saskia , Gahl Brigitta , Seifert Hans‐Helge , Bausch Kathrin 
Published: February 2024

AbstractObjectiveThe objective of this study is to investigate the incidence and risk factors for stone formation and recurrence in patients with neurogenic lower urinary tract dysfunction (NLUTD) in a real‐world cohort.Materials and methodsA retrospective cohort study was conducted on all patients with NLUTD who underwent bladder stone treatment between 2010 and 2022. Univariate and multivariate Cox models were used to identify the potential risk factors for stone recurrence.ResultsAmong 114 patients included in the study, 30% experienced stone recurrence. The most common stone components were carbonate apatite phosphate and magnesium ammonium phosphate. The overall recurrence rate was 14 cases per 100 patient years. Neurogenic detrusor overactivity had the highest recurrence rate. Risk factors for stone recurrence in the multivariate analysis were intermittent and suprapubic catheterization, and recurrent urinary tract infection (rUTI).ConclusionsPatients experienced multiple bladder stone recurrences. Close monitoring of bladder pressure and UTI with restrictive catheter application may reduce the risk of stone recurrence.
Urology never events in the United Kingdom: A retrospective 10‐year review
Authors: Loyala Jerocin Vishani , Ang Andrew , Down Billy , Howles Sarah A. 
Published: February 2024

AbstractObjectivesThe aim was to assess the prevalence of never events (NEs) specific to urology in the United Kingdom and identify commonly occurring themes.MethodsData from the National Health Service (NHS) NEs website were obtained and all NEs from 2012 to 2022 were reviewed. Urology‐specific NEs were identified and further analysed in their respective categories. Data regarding the total number of surgical procedures performed in the NHS specific to each specialty were obtained via the NHS Hospital Episode Statistics website.ResultsThere were 3972 NEs recorded over the 10‐year period with 95 (2.4%) of these as a result of urology surgery. The most common surgical intervention associated with a urological NE was ureteric stenting, which comprised 45/95 (47.4%) of all analysed NEs. These consisted of wrong site ureteric stent insertion (n = 29), wrong site ureteric stent removal (n = 9), wrong stent type (n = 5) and retained guidewires (n = 2). There were 7.14 million urology surgeries performed in the 10‐year period, and prevalence was 0.0013%.ConclusionNEs are fully preventable serious incidents in the NHS. This is the first study to investigate the prevalence of NEs in urology in the United Kingdom. This study demonstrates that in the last 10 years the prevalence of urology NEs is low at 0.0013%, with ureteric stent procedures accounting for more than half of the NEs. Urologists should be mindful of the potential for wrong site surgery in urologic stenting procedures.
Women who cry to manipulate others face more backlash than men
Authors: Pittarello Andrea , Motro Daphna 
Published: February 2024

AbstractTwo studies and one pilot study (Ntotal = 531) explore how observers react to men and women who cry in either good faith or in bad faith (i.e., with intention to manipulate). Using role congruity theory as a framework, we theorize that crying perceived as manipulative is less congruent with female stereotypes compared to male stereotypes. Accordingly, we find that women who cry in bad faith evoke less empathy and more anger from observers, who in turn judged them more harshly and are less willing to support them on a series of organizational outcomes. The same pattern did not emerge for men, for whom crying in good or bad faith did not seem to matter. This is in line with the idea that crying is overall less acceptable for men. In sum, we suggest that crying can have negative repercussions at work. This calls for greater attention to crafting interventions that can reduce discrimination and biases, ultimately fostering more positive workplace climates.
A rare case of palmar congenital nevus with sclerodermoid reaction
Authors: Bao Chengbei , Shen Shuyi , Gong Ting , Ji Chao 
Published: February 2024

Key Clinical MessagePalmar congenital nevus with sclerodermoid reaction has not been reported. It has the potential of deep extension following the fibrous bundle. The utilization of slow Mohs or frozen sections with immunohistochemistry staining was recommended.
Leukocytoclastic vasculitis caused by sulfamethoxazole‐trimethoprim
Authors: Bhatt Parjanya , Montreuil Nadine , Olayiwola Ayoola , Quiroz Tanya , Ruiz Felipe , Ayoade Folusakin 
Published: February 2024

Key Clinical MessageLeukocytoclastic vasculitis is a rare, small‐vessel vasculitis that can be caused by sulfamethoxazole‐trimethoprim. Most presentations involve skin rash but serious systemic involvement is possible. The precise mechanism is unclear but genetic and immune‐based tissue damage has been postulated. The rash often resolves with discontinuation of sulfamethoxazole‐trimethoprim with or without steroids.
Ionic liquid templated synthesis of cobalt‐substituted mesoporous aluminophosphates: A novel heterogeneous catalyst for selective oxidation of cyclohexane to cyclohexanol
Authors: Kumar Maddila Anil , Nagarjun Nagarathinam , Manyar Haresh , Selvam Parasuraman 
Published: February 2024

AbstractOrdered hexagonal mesoporous aluminophosphate and its cobalt‐substituted analogue were successfully synthesized using ionic liquid as a structure‐directing agent. The resulting materials were systematically characterized by various analytical, spectroscopic, and imaging methods, confirming the presence of divalent cobalt in the tetrahedral framework of the matrix. Further, the high surface area, pore volume, and thicker mesopore walls of these materials impart good thermal and hydrothermal stability. The mesoporous catalysts showed excellent activity towards the oxidation of cyclohexane reactions using hydrogen peroxide as an oxidant, with 98.5 % conversion and 90.4 % selectivity towards cyclohexanol.
Towards strengthening resilience of organizations by risk management tools: A scientometric perspective on COVID‐19 experience in a healthcare and industrial setting
Authors: Fabiano Bruno , Guastaferro Mariangela , Pettinato Margherita , Pasman Hans J. 
Published: February 2024

AbstractDuring the COVID‐19 pandemic, the healthcare system and the global supply chain were exposed to an unpredicted event, which increased awareness about the need of more effective strategies to support decision‐making process and to empower safety barriers. In this work, a combined scientometric and systematic review was performed to analyze tools and methodologies able to combine resilience with more traditional risk assessment, learning from the experience posed by the COVID‐19 crisis. Bibliometric and literature content analyses were carried out focusing on resilience management upon the incoming of an unexpected event. The systematic analysis of the methods and models developed on the basis of different pandemic waves provides a natural guide for future research development.
Discretization error estimation for EU‐DEMO plasma‐edge simulations using SOLPS‐ITER with fluid neutrals
Authors: Van Uytven Wim , Dekeyser Wouter , Subba Fabio , Wiesen Sven , Horsten Niels , Vervloesem Nathan , Baelmans Martine 
Published: February 2024

AbstractA grid refinement study is performed for mean‐field plasma boundary simulations with fluid neutrals in an EU‐DEMO geometry. In general, grid convergence of the simulations is achieved, with differences between the finest and second‐finest grid of <5% for the majority of the quantities of interest. The estimated discretization errors for the original 96 × 36 grid are mostly in the 4%–25% range. However, it is also shown that exceptions are possible due to the non‐linear nature of plasma boundary codes. Hence, it is advised to regularly perform grid refinement studies on subsets of cases.
Deltas: New paradigms
Authors: Zavala Carlos , Arcuri Mariano , Zorzano Agustin , Trobbiani Valentín , Torresi Antonela , Irastorza Ainara 
Published: February 2024

AbstractDeltas are deposits directly accumulated by land‐generated gravity flows in a standing body of water. The paradigm of deltaic sedimentation has dramatically changed during recent years, from the popular very simplified ternary models of marine littoral deltas towards more realistic and comprehensive models, considering the importance of sediment‐laden river discharges. Ternary delta models were designed for clean rivers, where a stream flow drags the sediments. Depending on the basin dynamics, these littoral deposits can be modified, forming tidal‐dominated, wave‐dominated or fluvial‐dominated littoral deltas. In recent years, a new classification of delta systems was proposed, based on contrasting the salinity of the receiving water body with the bulk density of the incoming fluvial discharge. Rivers are highly dynamic systems, and their discharges can be very variable in terms of flow duration and sediment concentration. Additionally, the salinity of the receiving water body can exhibit significant variability, especially in closed lakes and epicontinental seas, ranging from freshwater to brines. This scenario allows the distinction of three major delta categories (hypopycnal, homopycnal and hyperpycnal deltas) which can be in turn subdivided, defining seven delta types. Hypopycnal deltas form when the bulk density of the incoming flow is lower than the density of the water in the basin, allowing the definition of three delta types, corresponding to hypersaline littoral deltas, marine littoral deltas and brackish littoral deltas. Homopycnal deltas form when the bulk density of the incoming flow is similar to the density of the water in the basin, defining a delta type termed homopycnal littoral deltas. Hyperpycnal deltas form when the bulk density of the incoming flow is higher than the density of the water in the basin, allowing the definition of three categories termed hyperpycnal littoral deltas, hyperpycnal subaqueous deltas and hyperpycnal fan deltas.
Gravity flow deposits in Mesozoic sediments of Chukotka microplate (North‐East Russia)
Authors: Tuchkova Marianna I. , Vatrushkina Elena V. , Sokolov Sergey D. 
Published: February 2024

AbstractIn the Mesozoic succession of the Anyui–Chukotka fold system (North‐East Russia), five stratigraphic intervals were recognised that have an abundance of gravity flow deposits. These are the Olenekian (Lower Triassic), Upper Carnian, Upper Norian, Oxfordian–Kimmeridgian and Valanginian. The Triassic gravity flow deposits formed on the south‐facing, passive margin of the Chukotka microplate and consist of greywackes and lithic arenites. Palaeocurrent data indicate that the flows were directed towards the south‐east. The Olenekian gravity flow units consist of clast‐rich sandstone deposited on the continental slope, and clast‐poor sandstone deposited at the base of the slope. Upper Carnian mud‐poor sandstones were deposited at the base of the slope and the Norian thin‐bedded turbidites were upper to mid‐slope deposits. The continental margin was affected by tectonism and was uplifted in the latest Triassic–earliest Jurassic, possibly due to the initiation of the southward translation of the Arctic Alaska–Chukotka microplate. Following an Early–Middle Jurassic uplift of the area, sedimentation resumed in the Late Jurassic and earliest Cretaceous. Several syn‐orogenic depressions (Rauchua, Pegtymel, Pevek, Myrgovaam and Kytepveem) developed on the south‐western margin of the Chukotka microplate, and deposition in these basins included gravity flow deposits at various times. In both the Oxfordian–Kimmeridgian and Valanginian successions, gravity flow deposits included arkosic and subarkosic sandstones with a northern source area of granitoid complexes and deformed Triassic strata. The intervening Tithonian–Berriasian gravity flow deposits consisted mainly of thin‐bedded turbidites. These sediments had a southern source, which included a volcanic arc that had accreted to the southern margin of the Chukotka microplate.
Ritualized ink use during visual courtship display by males of the sexually dimorphic cuttlefish Sepia andreana
Authors: Nakayama Arata , Momoi Shunsuke , Sato Noriyosi , Kawamura Tomohiko , Iwata Yoko 
Published: February 2024

AbstractVisual display is a crucial aspect of courtship, and their success relies on both display quality and the surrounding environment, such as the visual background. Cephalopods may release ink when attacked by predators or during aggressive interactions with conspecifics. Here, we report that ink is used as a part of the courtship display by males of the cuttlefish species Sepia andreana. Males of this species engage in a highly ritualized multimodal courtship using a pair of markedly long sexually dimorphic arms. At the climax of the courtship, the male releases a diffuse backdrop of ink near himself and then performs the specific courtship display by extending his sexually dimorphic arms and altering his body pattern to pale in front of this ink backdrop, and then proceeds to mate. This novel use of cephalopod ink could make the surroundings darker and more homogeneous, potentially serving as a temporary modification of the visual environment for courtship display.
A prediction model for estimating NT‐proBNP in a general Japanese population: the Toon Health Study
Authors: Inoue Katsuji , Yamamoto Kazumichi , Higashi Haruhiko , Takata Yasunori , Inaba Shinji , Miyazaki Shigehiro , Higaki Akinori , Saito Makoto , Osawa Haruhiko , Yamaguchi Osamu 
Published: February 2024

AbstractAimsAs part of the Toon Health Study, which is an ongoing population‐based cohort study, we aimed to develop a prediction model for N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in a general Japanese population. We sought to explore the influence of various demographic and clinical factors on NT‐proBNP levels and assess the model's performance. In addition, our objectives included internal validation and investigation of the diagnostic potential of the observed‐to‐predicted NT‐proBNP ratio (OPR) at baseline for predicting the risk of heart failure with preserved ejection fraction (HFpEF).Methods and resultsIn this prospective cohort study, participants were recruited from Toon City, Japan, as part of the larger Toon Health Study, focusing on cardiovascular risk factors. We measured the NT‐proBNP levels and used linear regression with penalization (ridge regression) to develop the model. The model incorporated 10 prespecified predictors (age, gender, body mass index, diastolic blood pressure, heart rate, haemoglobin, albumin, total cholesterol, haemoglobin A1c, and estimated glomerular filtration rate) and underwent assessment using R2 and root mean squared error (RMSE). Internal validation was conducted through bootstrapping. In a post hoc analysis, we explored the OPR's diagnostic potential using 5 year follow‐up data (n = 636) to predict the elevation of NT‐proBNP > 125 pg/mL at the 5 year follow‐up as the risk of HFpEF. A total of 2505 participants (age: 60.4 ± 12.9 years, men: 35%) were enrolled in this study. There was a linear relationship between the observed and predicted values of NT‐proBNP in which the logarithm of observed NT‐proBNP was <6, which corresponds to 403 pg/mL in NT‐proBNP. The prediction model demonstrated satisfactory performance (R2: 0.291, RMSE: 0.688), with age identified as a dominant predictor. The stability of the model was underscored by the internal validation. The OPR at baseline predicted NT‐proBNP > 125 pg/mL at the 5 year follow‐up with an area under the curve of 0.793.ConclusionsThis study introduces the first prediction model for NT‐proBNP in a general Japanese population. Although the model has acceptable performance, ongoing refinement is essential. Our transparent approach to model development, alongside a web‐based interactive tool, lays the groundwork for further improvements and external validation. The OPR holds potential for predicting the future risk of HFpEF. This research contributes to understanding the nuanced influence of patient backgrounds on levels of NT‐proBNP in asymptomatic individuals within the context of a broader population‐based cohort study.