bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why do travelers return to the Physical Museum? A push-pull-mooring framework
Authors: Yu Xiaofan , Ye Yichen , Wu Shan 
Published: February 2024

Abstract
This research aims to empirically investigate how travelers transition from online to physical museums by utilizing and expanding the push-pull-mooring (PPM) model. Drawing from earlier studies and the present condition of museum tourism, this study identifies three push factors (dissatisfaction, technostress, and information overload), five pull factors (social interaction, perceived value, visual aesthetic, immersive experience, and perceived enjoyment), and three mooring factors (past experience, habit and switching cost). Travelers to the physical museum provided 434 legitimate questionnaires in total. The hypotheses were tested through structural equation modeling. The primary conclusions drawn from this research include: 1. Switching behavior is primarily influenced by push factors, pull factors, experience, and habit, with pull factors being the main driver of switching behavior. 2. Perceived value is the key factor among the pull factors, while dissatisfaction is the main factor in push factors. 3. Past experience diminishes the influence of push factors on switching behavior. This paper utilizes an expanded Push-Pull-Mooring (PPM) framework to investigate traveler-switching behavior in museum tourism. Furthermore, this paper offers valuable insights into converting behavior from online to physical museums.
Recurrent Fever of Unknown Origin and Unexplained Bacteremia in a Patient with a Novel 4.5 Mb Microdeletion in Xp11.23-p11.22
Authors: Lee Cho-Rong , Kim Man Jin , Park Sang-Heon , Kim Sheehyun , Kim Soo Yeon , Koh Seong-Joon , Choi Murim , Chae Jong Hee , Park Sung-Gyoo , Moon Jangsup 
Published: February 2024

Abstract

Fever of unknown origin (FUO) remains a formidable diagnostic challenge in the field of medicine. Numerous studies suggest an association between FUO and genetic factors, including chromosomal abnormalities. Here, we report a female patient with a 4.5 Mb Xp microdeletion, who presented with recurrent FUO, bacteremia, colitis, and hematochezia. To elucidate the underlying pathogenic mechanism, we employed a comprehensive approach involving single cell RNA sequencing, T cell receptor sequencing, and flow cytometry to evaluate CD4 T cells. Analysis of peripheral blood mononuclear cells revealed augmented Th1, Th2, and Th17 cell populations, and elevated levels of proinflammatory cytokines in serum. Notably, the patient exhibited impaired Treg cell function, possibly related to deletion of genes encoding FOPX3 and WAS. Single cell analysis revealed specific expansion of cytotoxic CD4 T lymphocytes, characterized by upregulation of various signature genes associated with cytotoxicity. Moreover, interferon-stimulated genes were upregulated in the CD4 T effector memory cluster. Further genetic analysis confirmed maternal inheritance of the Xp microdeletion. The patient and her mother exhibited X chromosome-skewed inactivation, a potential protective mechanism against extensive X chromosome deletions; however, the mother exhibited complete skewing and the patient exhibited incomplete skewing (85:15), which may have contributed to emergence of immunological symptoms. In summary, this case report describes an exceptional instance of FUO stemming from an incompletely inactivated X chromosome microdeletion, thereby increasing our understanding of the genetics underpinning FUO.
Analysis of the characteristics of a green dental filling material made from a Zinc Oxide NPs, chitosan NPs and glass ionomer mixture
Authors: Rashwan G. M. , said Alaa Hassan , Mostafa M. 
Published: February 2024

Abstract

Glass ionomer cements (GIC) is a common material in dental applications. GIC have some disadvantage such as secondary caries and low bioactivity. Many efforts have been proposed to modify the antibacterial features of GICs to prevent the secondary caries. In this work, the antibacterial activity of three types of NPs (biogenic ZnO NPs, Chitosan NPs and GIC) as well as their nanocomposites (Chitosan/ZnO, Chitosan/GICC and Chitosan/GIC/ZnO) were investigated. The synthesized nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscope (TEM). The antibacterial activity of the synthesized nanocomposites was investigated against two gram positive (Bacillus and Staphelococas) and two gram negative (E. coli and Klebsiella pneumonia) bacterial strains using agar diffusion disk. The obtained results revealed that the produced nanocomposites have a glassy structure with different particle size distribution. A comparable antibacterial action was observed in the three nanocomposites compared to the positive control Gentamycin. Biogenic ZnO NPs/Chitosan nanocomposite showed the largest antibacterial activity followed by GIC/biogenic ZnO NPs/Chitosan nanocomposite against the four bacterial strains, which make it a promising candidate for dental filling applications.
Differences in the Interleukins profile in Inatentive-ADHD prepubertal children are probably related to comorbidities
Authors: González-Villén Raquel , Fernández-López Luisa , Checa-Ros Ana , Tortosa-Pinto Pilar , Aguado-Rivas Raquel , Garre-Morata Laura , Acuña-Castroviejo Darío , Molina-Carballo Antonio 
Published: February 2024

Abstract

Background. Inflammatory cytokines are involved in attention deficit/hyperactivity disorder (ADHD), a highly prevalent neurodevelopmental disorder.
Objetive. To quantify baseline levels of pro- and anti-inflammatory cytokines and their changes after treatment with methylphenidate (MPH) in prepubertal children with ADHD.
Methods. A total of 31 prepubertal children with ADHD were recruited. Based on the scores of the NICHQ Vanderbilt scales, the children were subclassified in only two ADHD presentations: ADHD-Attention Deficit (n= 13) or ADHD-Combined (n= 18). The children were also screened for Oppositional Desafiant Conduct Disorder (ODCD) and Anxiety Disorder. Blood samples were drawn at 09:00 h and after 4,63 ± 1,87 months of treatment. Four proinflammatory cytokines [interleukin-1 beta (IL-1β), IL-5, IL-6, and tumour necrosis factor alpha (TNFα)] and three anti-inflammatory cytokines (IL-4, IL-10, IL-13) were measured using a Luminex® assay. Statistic: Factorial analysis (Stata 15.1) was performed using instants (baseline – post-treatment), presentations, and ODCD as factors.
Results. Overall, there were no differences induced by treatment in the concentrations of interleukins (ILs) analysed in our group of pre-pubertal children with ADHD. Grouped by Presentations, the differences detected are present almost exclusively in ADHD-AD Presentation, usually with a concentration profile opposite to that observed in ADHD-C, and with interactions between comorbid Factors, with the ILs that reach the greatest statistical significance being IL-1β (p = 0.01) and IL-13 (p = 0.006). These differences are probably related to the ODCD factor, and these differences disappear after treatment.
Conclusion. The changes that we described in inflammatory cytokines in prepubertal children only in ADHD-AD presentation are probably related to comorbidities (specifically ODCD) and disappear after treatment, but do not be involved in the highly clinically favourable response to MPH in prepubertal children.
A Comprehensive Overview of Research Groups and Activities in the Field of Inertial Electrostatic Confinement Fusion
Authors: Wulfkühler Jan-Philipp , Bakr Mahmoud , Tajmar Martin 
Published: February 2024

Abstract
Inertial electrostatic confinement fusion has developed into a widespread academic field since its inception in the 1950s and 1960s. This paper provides an overview of the different research groups (universities and research institutes) and companies involved in the field of IECF and their scientific publications. A list of over 970 publications from 56 universities, 20 research institutes, and 25 companies was collected and analyzed. Also, an overview of more than 30 tabletop IECF devices and their performance is provided.
Research, Policy, and Practice Regarding Rehabilitation of Children with Developmental Disorder in Africa: A Scoping Review
Authors: Abaraogu Ukachukwu O. , Eleke Chidera P. 
Published: February 2024

Abstract
Background: Developmental disorders are topping the list of the Global burden of disease. While developed countries have been able to have a level of control over it, low-income and middle-income countries are yet to put the necessary measures towards curbing these disorders. Comparing African countries against other countries, some factors are key which if thoroughly evaluated and have actions taken on them.
Methods: This scoping review was conducted to identify literature relating to research, policies, and practice regarding the rehabilitation of children with developmental disorders. A systematic search was carried out between June 2023 and August 2023 on PEDro, PubMed, African Journal Online, Cochrane Library and Directory of Open Access Journals for identification of eligible literature.
Results: The search yielded 982 articles out of which 19 met the inclusion criteria. This shows that not so much work has been done regarding developmental disorders discussing policies or rehabilitation practice in Africa. The result was screened using Rayyan. Results from databases which cannot be exported in a format compatible with Rayyan were manually screened. 47% of the literature was from the Western African Region and Cerebral Palsy topped the list at 42%. No article was found on the policies regarding rehabilitation in children with developmental disorders in Africa. Diverse rehabilitation practices have been adopted and/or experimented on in Africa with none widely accepted.
Conclusions: Seeing that there is yet to be structured evidence and information on developmental disorders in the African context, research remains the way forward. More energy should be channelled by researchers towards the issue of developmental disorders in Africa. Enough and quality evidence translates to better policies which when properly implemented, brings forth better rehabilitation practice in the area of developmental disorders in Africa and globally too.
Students Are Not Motivated to Communicate in English: an Action Research
Authors: Baskota Prateet , Thapa Punam 
Published: February 2024

Abstract
There are many problems in classroom associated with English language teaching. Among them, lack of students’ motivation and interest to speaking English is one of the major problems. The purpose of our study is to motivate our students of Grade seven via various activities. Every teacher should arouse motivation and interest to speak English in the classroom by applying various kinds of teaching methods such as warm up activities, summarization techniques, picture description, and English Simple story to help them produce something by their own. Therefore, every teacher should engage students in various activities by understanding their level to encourage them and to reduce their anxiety and negative attitude in Speaking. Similarly, motivation plays significant role for acquiring Second language. Importantly, if teachers really want to help to sustain their self-confidence they need to know and use effective teaching strategies in the English as second language teaching.
Mucormycosis-induced brain abscess treatment without dura opening- a report of three cases
Authors: Firouzifar Mohammadreza , akbarpour maliheh 
Published: February 2024

Abstract
purpose Brain abscess following sinonasal mucormycosis is a rare but life-threatening condition that usually occurs during the patient's treatment. Therefore, it is important to pay close attention to its identification and treatment and since our knowledge is mostly based on case reports, a well-documented way of treatment for such cases is yet to be found.
Methods A retrospective case series study was conducted at a tertiary hospital. Initially, all patients with brain abscesses following sino-nasal mucormycosis were included, and then patients whose brain abscesses were treated without opening the dura during surgery were selected for the study. The patients received radical debridement of necrotic tissues as well as the infected bones adjacent to the brain abscess cavity. But the dura was not incised. Then they were treated medically for their underlying disease and also with Amphotericine-B. Their brain abscess was monitored 3 weeks post-operatively.
Results Three patients with an average age of 41 years were included in the study. All patients had a history of diabetes and had previously been treated for COVID-19 before developing symptoms of sino-nasal infection. The average size of the abscesses was less than 2 cm. Two patients had abscesses in the temporal lobe and one in the frontal lobe.
Conclusion Treating brain abscesses adjacent to the skull base by removing infected tissues and bones surrounding the brain abscess without opening the dura can be a viable treatment option for mucormycosis-induced brain abscesses of less than 2 cm.
Ethics approval statement: IR.TUMS.AMIRALAM.REC.1402.036
Inactivation of Deposited Bioaerosols on Food Contact Surfaces with UV-C Light Emitting Diode Devices
Authors: Sharma Aakash , Singh Amritpal , Pendyala Brahmaiah , Balamurugan Sampathkumar , Patras Ankit 
Published: February 2024

Abstract
The airborne transmission of infectious diseases and bioaerosol-induced cross-contamination pose significant challenges in the food, dairy, and pharma industries. This study evaluated the effectiveness of 279 nm UV-C LED irradiation for decontaminating bioaerosols, specifically containing microorganisms like E. coli (C3040- Kanamycin resistant), Salmonella Enteritis (ATCC 4931), and Pseudomonas fragi (ATCC 4973), on food contact surfaces. Borosilicate glass, silicon rubber, and stainless steel (316L) surfaces were selected for experimentation for their usage in the food industry. A 50µL cell suspension was aerosolized at 25 psi pressure using a 4-jet BLAM Nebulizer within a customized glass chamber and then deposited onto the surface of the coupons. The serial dilution approach was used for the microbial enumeration, followed by double plating. With a low RMSE and high R2 values, the biphasic kinetic model demonstrated the excellent goodness of fit parameters. At a UV-C dose of 6 mJ cm− 2, glass surfaces showed the maximum microbial inactivation ( i.e. 2.80, 3.81, and 3.56 log CFU/mL for E. coli, Salmonella, and P. fragi, respectively). Stainless steel and silicon rubber showed significant microbial inactivation but were consistently lower than glass. Our research indicates that UV-C LEDs can disinfect bioaerosols on food contact surfaces effectively.
Microbial occupational exposure in e-waste recycling: biological hazards, their sources, and potential toxic effects
Authors: Viegas Carla , Gomes Bianca , Dias Marta , Cervantes Renata , Pena Pedro , Gonçalves Sara , Almeida-Silva Marina , Carolino Elisabete , Twaruzek Magdalena , Caetano Liliana Aranha , Viegas Susana 
Published: February 2024

Abstract

E-waste management is a major environmental concern that also poses serious risks to occupational health. While e-waste workers are exposed to a variety of chemicals, little is known about occupational exposure to microbiological agents. This study aims to fill that gap. For that purpose, two e-waste facilities were assessed: one battery-recycling facility (BRF), and another facility (SRE) dedicated to e-waste sorting and storage before sending it for different processing. Filtering respiratory protection devices (FRPD, 24 samples) and settled dust (13 samples) were collected using standardized sampling approaches, and analyzed by culture-based, chemical and molecular methods. Workers also filled in a questionnaire regarding work activities and the use of FRPD. Microbial loads, fungal diversity, azole resistance, and prevalence of Aspergillus sections Fumigati and Flavi and mycotoxins (as surrogates of harmful fungal contamination) were determined. To estimate potential health effects related to exposure, the FRPD cytotoxicity was determined in human A549 lung and HepG2 hepatic cells. Microbial contaminants with pathogenicity and toxigenic potential were observed in FRPDs and settled dust. Aspergillus section Fumigati was widespread. The observed presence of Aspergillus section Flavi relates to the risk of exposure to aflatoxin B1 (a potent hepatocarcinogen). Four different mycotoxins were detected in 8% FRPD and 15% dust samples, including pathogenic fumonisin B1 and sterigmatocystin (below the limit of quantification). A low to moderate cytotoxic effect of sampled FRPD was observed, with human lung alveolar cells more sensitive than hepatic cells. No relevant azole resistance was observed, nor correlations between fungal reduced azole-susceptibility and fungal growth at 37ºC or cytotoxicity. In summary, it can be concluded that this approach using FRPD and settled dust presents a promising potential for screening occupational exposure to microbiological contaminants in e-waste management. More studies in this occupational context should be prioritized to identify critical biological hazards and to support the implementation of appropriate health risk mitigation strategies.
An Attentive LSTM with Fuzzy Network for Intelligent Optimal Routing in Wireless Sensor Networks using Enhanced Red Piranha-based Optimal Path Selection Mechanism
Authors: R Palani Kumar , R Asokan 
Published: February 2024

Abstract
Several agricultural processes can be greatly improved by data mining and sensor networks approaches. This action is controlling the amount of water used in agricultural crops. Furthermore, the Wireless Sensor Networks (WSN) have emerged as a more important technology in forming field. Utilizing energy and extending the lifespan of the sensor nodes is a key component of WSN design. The enormous problem of energy consumption reduction is used to increase the lifetime of the entire framework. Smart sensing IoT devices typically have low batteries and are not usually rechargeable. The effective protocols seek to extend structure life span while reducing the power consumption to prevent disruptions to the nodes installed for environment controlling and data collection. An intelligent deep learning-based routing in WSN is developed to enhance the network lifetime. This model provided efficient optimal routing, in which the routing decisions are taken by Attentive LSTM with Fuzzy (ALSTMFuzzy). Here, the routing decisions are selected based on the security, malicious node, link availability and scalability, etc. The effective routing is performed by the optimal path selection using Mutated Fitness-based Red Piranha Optimization (MFRPO). The path selection for intelligent routing is performed based on several multiple constrains like distance, delay, PDR, energy consumption and throughput. The developed intelligent routing in WSN system outcome is compared to existing models with effectiveness measures.
Community-acquired pneumonia associated with influenza co-infection caused by fusobacterium necrophorum: a case report and literature review
Authors: Cao Min , Huang Lin , Zhang Rong 
Published: February 2024

Abstract
Background
Fusobacterium necrophorum is a rare pathogen often associated with community-acquired pneumonia (CAP), especially when compromising healthy adults. This case report presents the first documented case of CAP caused by F. necrophorum in a young individual, providing valuable insights for the diagnosis and treatment of similar cases.
Case presentation
The patient, initially diagnosed with influenza, developed CAP caused by F. necrophorum. Despite one week of outpatient treatment with moxifloxacin, symptoms persisted, leading to hospitalization. Treatment with piperacillin tazobactam/imipenem and doxycycline, targeting atypical pathogens, did not result in improvement after admission. Conventional diagnostic methods failed to identify the causative pathogen, but metagenomics next-generation sequencing of bronchoalveolar lavage fluid confirmed it to be F. necrophorum. The patient showed significant improvement after ten days of targeted treatment with ornidazole and imipenem/piperacillin tazobactam and was discharged.
Conclusion
Uncommon pathogens, such as F. necrophorum, should be considered as potential culprits in young individuals with CAP when conventional cultures yield negative results but there is a strong suspicion of infection, especially if initial antibiotic therapy is ineffective.
Benchmarking Mechanistic Structural, Molecular Docking, ADMET and Biological Properties of Methyl- Imidazole Derivatives: Potential Anti-Cancer Agents
Authors: Agwupuye John A. , Koudjina Simplice , Gber Terkumbur E. , Zeeshand Muhammad , Ashishie Providence B. , Batoold Sidra , David Prince , Atohoun Guy Y. S. , Gbenou Joachim D. , Louis Hitler 
Published: February 2024

Abstract
The application of computational studies is crucial in optimizing the potential of prospective drug candidates by predicting their most important reactive properties. This approach not only reduces experimental costs but also provides precise methods for experimental achievements. It should be noted that the biological activity and toxicity of a drug is heavily influenced by the number and interaction of its chemical bonds. Heterocyclic compounds, particularly imidazole derivatives, have shown a significant advancement in synthesis, theoretical studies, and applications. Various software were employed, including Gaussian 16W, with GaussView 6.0.16, FMO using the Koopsman’s approximation, molecular docking, natural bond order analysis, pharmacokinetics, as well as ADMET properties, to perform the computational quantum calculations. A range of functional was explored to ensure accuracy and precision in the computational studies of the modeled nitrogen heterocyclic (Imidazole’s). This is particularly necessary as hybrid functional, which provides the best compromise between accuracy and computational effort, form the basis of the majority of practical DFT applications. Furthermore, the modeled compounds using molecular docking to determine their biological activities against various cancer proteins were screened. These findings potentially pave the way for the development of new drugs with enhanced efficacy and reduced toxicity.