bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and age, sex, and race disparities in time to second primary cancer from 1990 to 2019
Authors: Leung Tiffany H. , El Helali Aya , Wang Xiaofei , Ho James C. , Pang Herbert 
Published: December 2023

AbstractBackgroundDespite the growth in primary cancer (PC) survivors, the trends and disparities in this population have yet to be comprehensively examined using competing risk analysis. The objective is to examine trends in time to second primary cancer (SPC) and to characterize age, sex, and racial disparities in time‐to‐SPC.MethodsA retrospective analysis was conducted based on Surveillance, Epidemiology, and End Results (SEER). Two datasets for this study are (1) the discovery dataset with patients from SEER‐8 (1990–2019) and (2) the validation dataset with patients from SEER‐17 (2000–2019), excluding those in the discovery dataset. Patients were survivors of lung, colorectal, breast (female only), and prostate PCs.ResultsThe 5‐year SPC cumulative incidences of lung PC increased from 1990 to 2019, with the cumulative incidence ratio being 1.73 (95% confidence intervals [CI], 1.64–1.82; p < 0.001). Age disparities among all PCs remained from 2010 to 2019, and the adjusted HRs (aHRs) of all PCs were above 1.43 when those below 65 were compared with those 65 and above. Sex disparity exists among colorectal and lung PC survivors. Racial disparities existed among non‐Hispanic (NH) Black breast PC survivors (aHR: 1.11; 95% CI: 1.07–1.17; p < 0.001). The types of SPC vary according to PC and sex.ConclusionsOver the past three decades, there has been a noticeably shortened time‐to‐SPC among lung PC survivors. This is likely attributed to the reduced number of lung cancer deaths due to advancements in effective treatments. However, disparities in age, sex, and race still exist, indicating that further effort is needed to close the gap.
A New Method for Urea Synthesis under Environmental Conditions Based on Nucleophilic Addition Reaction During Electrochemical CO2 Reduction
Authors: Li Peize , Zhang Zhiguo , Yang Xiaoju , Zhu Yanbin , Zhou Zhiming , Jiang Xingxing , Wang Qinglong , Gao Xiaowu , Yang Xuan , Shen Yan , Wang Mingkui 
Published: December 2023

AbstractUrea (H2NCONH2) is a commercially indispensable chemical as a fertilizer and starting material for the manufacture of many other products. Currently, commercial urea can be prepared with an energy‐consuming process by combining liquid ammonia (NH3) and liquid carbon dioxide (CO2) under high‐temperature and high‐pressure conditions. An alternative approach for synthesis of urea may involve electrochemical synthesis reactions that occur under aqueous and ambient conditions. Here, we propose synthesis of urea via nucleophilic addition reaction during an electrochemical CO2 reduction process in NH4HCO3‐containing electrolytes. The urea formation at a rate of 0.11 mmol g−1 h−1 was achieved on a polycrystalline Au electrode (area: 1 cm2) at a potential of −1.4 V (vs. saturated calomel electrode). Furthermore, the detailed investigations including in‐situ spectroscopic analysis and isotopic labeling characterization reveal the capability of producing urea could be mainly attributed to a spontaneous reaction between the NH3 molecule and the CO2⋅− intermediate. This study promotes the exploration of electrochemical synthesis of high‐value‐added products.
Investigating the Influence of Amorphous/Crystalline Interfaces on the Stability of IrO2 for the Oxygen Evolution Reaction in Acidic Electrolyte
Authors: Nga Ngo (Sarah Ngo) Thi Hong , Love Jonathan , O'Mullane Anthony P. 
Published: December 2023

AbstractInvited for this issue's Front Cover is the group of Prof. Anthony O'Mullane from the School of Chemistry and Physics, Queensland University of Technology (QUT). The cover picture shows the presence of crystalline and amorphous domains in an electrodeposited IrO2 film which demonstrate different activity for the oxygen evolution reaction. The presence of amorphous/crystalline interfaces was found to improve the stability of the electrocatalyst. Cover design by Thi Hong Nga Ngo. Read the full text of the Research Article at 10.1002/celc.202300438.
Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N‐N Axis†
Authors: Ge Fang‐Bei , Yin Qi‐Kun , Lu Chuan‐Jun , Xuan Xuan , Feng Jia , Liu Ren‐Rong 
Published: December 2023

Comprehensive SummaryAtroposelective synthesis of N‐N atropisomers is an emerging area but remains underexplored; in particular, the synthesis of N‐N benzimidazole atropisomers is still unprecedented. Herein, the first enantioselective synthesis of N‐N benzimidazole atropisomers via the palladium‐catalyzed de novo construction of benzimidazole skeleton is presented. With readily available palladium catalyst and biphosphine ligand, a broad range of nonbiaryl benzimidazole and indole‐benzimidazole atropisomers were conveniently accessed in high yields and with excellent enantioselectivities. Significantly, these N‐N benzimidazole atropisomers showed great antitumor activity and selectivity to breast cancer MCF‐7 cells. The simple catalytic system, broad substrate scope, high enantioselectivity, and good bioactivity make this approach highly attractive.
Palladium‐Catalyzed [4+2] and [6+2] Dipolar Cycloadditions for the Construction of Benzo[d]isothiazole 1,1‐Dioxide Fused 1,3‐Oxazinanes and 1,3‐Oxazocanes†
Authors: Chen Lei , Xie Hongling , Xue Yu , Han Zhengyu , Sun Jianwei , Huang Hai 
Published: December 2023

Comprehensive SummaryThe Pd‐catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic compounds. This study developed the dipolar [4+2] and [6+2] cycloaddition reactions of benzo[d]isothiazole 1,1‐dioxides (BDs) leading to the synthesis of BD‐fused 1,3‐oxazinane and 1,3‐oxazocane derivatives, respectively. In particular, the synthesis of BD‐fused 1,3‐oxazinanes demonstrated regio‐ and enantioselective characteristics, resulting in products with good yields, enantioselectivity and regioselectivity (if applicable). Furthermore, the [6+2] cycloaddition reaction developed in this work represented the first strategy for the synthesis of medium‐sized ring compounds based on BDs.
Grading medullary thyroid carcinoma on fine‐needle aspiration cytology specimens with the International Medullary Thyroid Carcinoma Grading System: A cytologic–histologic correlation
Authors: Viswanathan Kartik , Behrman D. Blake , Lubin Daniel J. 
Published: December 2023

AbstractBackgroundMedullary thyroid carcinoma (MTC) is a rare cancer of parafollicular C‐cell origin. The International MTC Grading System (IMTCGS) incorporates mitotic activity, the presence of necrosis, and the Ki67 proliferation rate (PR) to classify MTCs as low or high grade. The ability to predict IMTCGS grade in cytology was assessed.MethodsMTCs with cytology and subsequent surgical follow‐up were reviewed. Cytology slides were reviewed for mitotic figures, apoptoses, and necrosis, and a Ki67 PR was calculated when possible. Findings were correlated with final IMTCGS grade.ResultsTwenty‐five MTC fine‐needle aspirations (FNAs) were identified, with nine identified as high grade (36%). By using a PR cutoff of 5%, Ki67 on FNA material (Ki67FNA) showed 92% concordance (n = 22 of 24) with surgical Ki67 and a correlation coefficient (R2) of 0.72. Sensitivity and specificity of Ki67FNA for predicting high‐grade MTC were 38% and 100%, respectively. Multiple mitotic figures were present in a single slide of 43% (n = 3 of 7) of evaluable high‐grade MTCs, whereas only one of 16 low‐grade MTCs showed a single mitotic figure. Definitive apoptoses were present in five of seven high‐grade MTC FNAs but were absent in 16 low‐grade MTCs. The sensitivity and specificity of apoptoses/necrosis on cytology for high‐grade MTCs were 71% and 88%, respectively.ConclusionsKi67FNA ≥5% shows low sensitivity but high specificity for predicting high‐grade MTC. The presence of multiple mitotic figures in a single slide or definitive apoptotic bodies are both highly suggestive of high‐grade MTC, and should warrant a close examination for necrosis and a careful Ki67 PR count.
Realizing High Performance Tunable Sensing Mode and Selectivity of Metal Ions Based on Carbon Dot
Authors: Devi Lamabam Rebika , Devi Henam Sylvia , Singh Henam Premananda , Singh Thiyam David 
Published: December 2023

AbstractWe have adopted a straightforward, eco‐friendly and economically profitable pyrolysis route of tailoring quantum dot size carbon particles (CD) from the leaves of Arundo donax. The synthesized uniformly dispersed CD1 and CD2 have an average diameter of 4.5 nm and 3.5 nm respectively as determined via HRTEM. FT‐IR analysis corroborated nitric acid treatment leads to rich surface functionalization of CD2. Experimentally estimated average fluorescence (FL) lifetime of the as‐prepared CD1 and CD2 are 2.31 ns and 3.87 ns respectively. Juxtapose to other metal ions, Cd+2 ions can efficiently quench FL of CD1, while Cr+6 ions, on contrary, prominently enhanced FL of CD2. Benefitting from their FL response, a turn off sensor was built using CD1 to detect Cd+2 ions and a turn on‐off sensor by CD2 to sense Cr+6 with impressive limit of detections of 2.58 nM and 1.73 nM respectively. They exhibit superior performance compare to other documented nanoscopic materials. The FL “turn off” interaction mechanism of CD1 was attributed mainly to static quenching. While that of “turn on‐off” mechanism for CD2 was ascribed to chelation enhanced fluorescence phenomenon and a rare partial combination of inner filter effect plus dominate dynamic type of quenching.
Curriculum in special school contexts: A collaged framework for personalised, individual student learning
Authors: Ronksley‐Pavia Michelle 
Published: December 2023

AbstractInterpreting and enacting curriculum in any school is a complex undertaking, even more so in special school contexts where teachers must develop and enact appropriate curriculum modifications and accommodations for small groups of students and individual students. In special education contexts, educational modifications are changes teachers make based on a standardised curriculum, in order to be able to support the individual learning of students with intellectual and other profound disabilities, in terms of personalising learning for each student. These modifications are derived from teachers' curriculum (re)interpretations. Conversely, educational accommodations are the adjustments that teachers make in how they deliver the interpreted curriculum through individual learning episodes without changing the existent learning foci. This article presents a theorisation of how some special school educators interpret and reinterpret standardised curriculum to support the individual learning needs of students with moderate to profound disabilities through operationalising a theoretical framework of personalised learning. Operationalising personalised learning in special school contexts is theorised to be a collaged hermeneutical circle, where special education teachers work to (re)interpret curriculum, alongside the individual learning needs evidenced through teacher assessments and observations, and from student individual education plans. Within special school contexts, teachers approach the Australian Curriculum text as collaborative teams and engage in dialogue and planning about the curriculum to be taught and assessed. Thus, they aim to ensure that their students engage with the appropriate curriculum and have opportunities for learning on the same basis as students without their specific needs (i.e. students without disability). Unlike teachers in mainstream schooling contexts, teachers in special schools must (re)interpret curriculum that has not been explicitly developed for the unique learning needs of students with profound disability.
BEE‐quest of the nest: A novel method for eDNA‐based, nonlethal detection of cavity‐nesting hymenopterans and other arthropods
Authors: Sickel Wiebke , Kulow Josephine , Krüger Lasse , Dieker Petra 
Published: December 2023

AbstractWild bee populations are facing strong declines due to a variety of stressors, such as habitat loss and pesticide use. Research focused on wild bees has increased over the last three decades, yet species identifications are still relying on lethal sampling approaches, followed by time‐ and labor‐intensive pinning and morphological analysis by experts. The use of DNA metabarcoding for species detection offers a time‐ and cost‐effective complement to traditional approaches and can potentially facilitate nonlethal sampling. We developed a DNA metabarcoding workflow to identify cavity‐nesting Hymenoptera using environmental DNA collected from vacated nest tubes. We compared different nest sizes and sample types and assessed the effect of these parameters on Hymenoptera species detection rates. We also tested whether our method could detect multiple species in mixed‐species nests. The eDNA results were compared to data from morpho‐taxonomical species identifications. Despite limited DNA quantity, we detected Hymenoptera at the species level in 57.4% of our samples. Hymenoptera detection was also possible from single brood cells. In mixed‐species nests, we correctly detected the presence of multiple species. In nests of solitary wasps, we additionally detected other arthropods, which are probably the remains of larval provisions. Morphological and molecular data agreed in large parts. This eDNA approach offers the opportunity for the implementation of large‐scale and nonlethal monitoring of cavity‐nesting Hymenoptera that additionally provides valuable information on trophic interactions.
Acidity constants and protonation sites of cyclic dinucleotides determined by capillary electrophoresis, quantum chemical calculations, and NMR spectroscopy
Authors: Štěpánová Sille , Andris Erik , Gutten Ondrej , Buděšínský Miloš , Dejmek Milan , Břehová Petra , Rulíšek Lubomír , Kašička Václav 
Published: December 2023

AbstractCyclic dinucleotides (CDNs) are important second messengers in bacteria and eukaryotes. Detailed characterization of their physicochemical properties is a prerequisite for understanding their biological functions. Herein, we examine acid–base and electromigration properties of selected CDNs employing capillary electrophoresis (CE), density functional theory (DFT), and nuclear magnetic resonance (NMR) spectroscopy to provide benchmark pKa values, as well as to unambiguously determine the protonation sites. Acidity constants (pKa) of the NH+ moieties of adenine and guanine bases and actual and limiting ionic mobilities of CDNs were determined by nonlinear regression analysis of the pH dependence of their effective electrophoretic mobilities measured by CE in aqueous background electrolytes in a wide pH range (0.98–11.48), at constant temperature (25°C), and constant ionic strength (25 mM). The thermodynamic pKa values were found to be in the range 3.31–4.56 for adenine and 2.28–3.61 for guanine bases, whereas the pKa of enol group of guanine base was in the range 10.21–10.40. Except for systematic shifts of ∼2 pKa, the pKa values calculated by the DFT‐D3//COSMO‐RS composite protocol that included large‐scale conformational sampling and “cross‐morphing” were in a relatively good agreement with the pKas determined by CE and predict N1 atom of adenine and N7 atom of guanine as the protonation sites. The protonation of the N1 atom of adenine and N7 atom of guanine in acidic background electrolytes (BGEs) and the dissociation of the enol group of guanine in alkaline BGEs was confirmed also by NMR spectroscopy.
Anti‐skin aging effect of sea buckthorn proanthocyanidins in D‐galactose‐induced aging mice
Authors: Liu Xinying , Yuen Michael , Yuen Tina , Yuen Hywel , Wang Min , Peng Qiang 
Published: December 2023

AbstractOxidative stress in skin cells caused by changes in the external environment is one of the principal causes of skin aging. Sea buckthorn proanthocyanidins (SBPs) have good free radical scavenging ability. We established a senescence model by injecting 500 mg/kg D‐galactose into the dorsal necks of mice, and then different doses of SBP (25, 50, and 100 mg/kg) were gavaged to explore the effects of SBP on the skin tissues of senescent mice and elucidate the related mechanism of action. The results reveal that SBP can alleviate the skin aging phenomenon caused by D‐galactose‐induced aging. It can also enhance the total antioxidant capacity in the body, thereby strengthening the body's antioxidant defense capability. In addition, SBP can effectively improve skin aging by regulating the TGF‐β1/Smads pathway and MMPs/TIMP system, increasing the relative content of Col I and tropoelastin, further maintaining the stability of collagen fiber and elastic fiber structure. These results will provide the development and production of the antioxidant function of cosmetics and health products, providing a new train of thought.
Social, economic, and health indexes affecting epidemiology of preterm birth: A cross‐sectional study
Authors: Mostafaei Shayan , Shamshirsaz Alireza A. , Norooznezhad Amir H. 
Published: December 2023

AbstractBackground and AimPreterm birth (PTB) accompanies with morbidities and mortality among newborns. This study aimed to show that different factors such as economic (adjusted net national income and gross domestic product [GDP] per capita), human developmental (human developmental index), and health (overall health performance, pregnancy prenatal care rate, and modeled estimated maternal mortality rate) indexes might influence the prevalence of PTB.MethodsTo this, the top 10 countries with the highest and lowest prevalence of PTB were extracted from the Global Burden of Disease report for PTB. Then, we have gathered some common indexes for economic (adjusted net national income and GDP per capita), health‐related (overall health performance, pregnancy prenatal care rate, and modeled estimated maternal mortality rate), and combined developmental (human developmental index) factors from different resources including World Bank and United Nations for those countries. The truncated Bayesian linear regression model, decision tree, and k‐means clustering algorithms were used for data analysis.ResultsThe results showed Pregnancy Prenatal Care Rate index has a significant effect on the PTB rate in the top 10 countries with the highest prevalence of PTB. Also, for the top 10 less prevalent countries for PTB, it was shown that modeled estimated maternal mortality rate, human developmental index rank, and pregnancy prenatal care rate have significant effects on PTB rate. In addition, the clustering based on the similarities in socioeconomic, human developmental, and health indexes were approximately like with the clustering of the countries based on the PTB rates (Rand index = 0.823).ConclusionThe results showed studies on the epidemiology of PTB (either worldwide or nation‐based) should consider these confounder factors to obtain accurate results.
The effect of the holy Quran recitation and listening on anxiety, stress, and depression: A scoping review on outcomes
Authors: Moulaei Khadijeh , Haghdoost Ali‐Akbar , Bahaadinbeigy Kambiz , Dinari Fatemeh 
Published: December 2023

AbstractBackground and AimAnxiety, stress, and depressive disorders as common mental health problems have adverse effects in different populations. Holy Quran recitation and listening can help reduce these disorders. Therefore, the aim of this study was to investigate the effect of the Holy Quran on anxiety, stress, and depression.Materials and MethodsTo retrieve eligible studies, we searched PubMed, Web of Science, and Scopus databases. The articles were screened and chosen by three researchers. The selection of studies and the data extraction from the studies were done by three researchers using the data collection form based on the inclusion and exclusion criteria. Disagreements were resolved by consulting the third and fourth researchers. To report scoping review, we used the PRISMA cheklist.ResultsA total of 174 articles were retrieved from three databases and after removing irrelevant and repetitive articles, 15 articles were included in the current review. All studies were performed in Asia countries. Most studies have examined the effect of Holy Quran recitation and listening on anxiety (45%), stress (30%), and then depression (25%), respectively. The Beck Depression Inventory was the most widely used tool to evaluate the effect of Holy Quran recitation and listening on reducing anxiety, depression and stress. “Reducing the level of anxiety, stress, and depression” and “Simple, affordable, practical and cost‐effective treatment to reduce depression and anxiety” were the most important outcomes of holy Quran recitation.ConclusionsBased on the results of this study, Quran recitation and listening can be applied as a useful nonpharmacological treatment to reduce anxiety, stress, and depression.
Association between history of hookah use and symptoms of postpartum depression: A population‐based study
Authors: Haile Zelalem T. , Karim Sabrina , Murton Kasey , Patibandla Sravya , Haider Mohammad Rifat 
Published: December 2023

AbstractObjectiveAlthough several biologic, psychosocial, and behavioral factors have been linked to postpartum depressive symptoms, studies examining the association between non‐cigarette tobacco products and symptoms of postpartum depression are currently lacking. This study examined the association between hookah use and postpartum depressive symptoms.MethodsA cross‐sectional study was conducted using data from the US Centers for Disease Control and Prevention's Pregnancy Risk Assessment Monitoring System 2016–2020. Self‐reported data on hookah use in the last 2 years and maternal mental health were captured using a structured questionnaire. Descriptive and inferential statistics were performed.ResultsThe final study sample consisted of 106 894 participants. Approximately 8.2% of the participants reported postpartum depressive symptoms and 4.1% reported hookah use in the past 2 years. Compared with those without postpartum depressive symptoms, participants with postpartum depressive symptoms were more likely to be hookah users (5.5% vs 4.0%, P < 0.001). After adjustment for confounders, the odds of having postpartum depressive symptoms were significantly higher among participants who used a hookah in the past 2 years compared with non‐users; adjusted odds ratio (95% confidence interval) 1.20 (1.03–1.40); P = 0.022.ConclusionIn a large, population‐based sample of US women, hookah use in the past 2 years significantly increased the odds of having postpartum depressive symptoms, independent of potential confounders. This finding underscores the need for healthcare providers to communicate effectively about the health risks of hookah use.
The effect of genital hygiene behaviors and vaginal douching of pregnant women on preterm labor
Authors: Arikan Melisa , Kocaöz Semra , Kizilirmak Aynur 
Published: December 2023

AbstractObjectiveTo determine the effect of genital hygiene behavior (GHB) and vaginal douching (VD) of pregnant women on preterm labor (PTL).MethodsThis study, which was conducted with 365 pregnant women, is a cross‐sectional study. Data were collected using a questionnaire and the Genital Hygiene Behavior Inventory (GHBI) was applied.ResultsThe ratios of PTL diagnosis and VD practice, and mean GHBI scores of the pregnant women were 35.1%, 9.6%, and 64.42 ± 10.44, respectively. The prevalence of receiving a diagnosis of PTL was significantly higher in those who changed their underwear two to three times a week, took baths while sitting, cleansed their perineum with water using their hands, removed pubic hair at intervals of 2 months or longer, and performed VD. It was found that poor GHB and VD practices increased the rate of PTL and, in particular, VD was found to increase the risk of PTL around eight‐fold.ConclusionThese results can help pregnant women to understand the relationship between genital hygiene and PTL and show the importance of being educated by health professionals about this issue.