bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rutas metabólicas intracelulares que intervienen en el desarrollo tumoral en pacientes con síndrome metabólico
Authors: Calonge-Solano Christian Daniel , De La Hoz-Herrera Gustavo Elías , Castilla-Velásquez María Juliana 
Published: December 2023

Introducción: el síndrome metabólico se caracteriza por la aparición de signos y síntomas consecuentes a alteraciones metabólicas e inflamatorias a nivel molecular y celular los cuales generan cambios en las diferentes vías de señalización celular mediada por leptina, adiponectina y citoquinas o la activación de cascadas tales como la vía RAS, PI3K/AKT mediada por IGF-1 la cuales contribuyen a proliferación celular descontrolada y desarrollo tumoral. Objetivos: Describir las rutas metabólicas intracelulares de las señales que intervienen en el desarrollo tumoral de pacientes con síndrome metabólico. Métodos: Se realizó una descripción narrativa implementando bases de datos PubMed, Elsevier, Medline y Cochrane de estudios entre 2006 y 2021 que tuvieran como temas central síndrome metabólico, cáncer, obesidad. Se incluyeron artículos en inglés, español y otros idiomas. Resultados: La obesidad es un factor predisponente para múltiples patologías, el estado inflamatorio crónico de aquellos pacientes con IMC >30 kg/ m2 los predispone al desarrollo de neoplasias por alteración en la activación de rutas metabólicas mediadas por citoquinas y hormonas. Conclusiones: la obesidad, hipertensión arterial, diabetes mellitus y dislipidemias encabezan la lista de las enfermedades crónicas no transmisibles con alta tasa de morbimortalidad a nivel mundial. Se debe tener en cuenta que el síndrome metabólico y la obesidad son factores de riesgo que podrían influir en el desarrollo de tumores.
The use of mathematical editors in the training of mathematics teachers
Authors: Антропова Г.Р. , Матвеев С.Н. , Киселев Б.В. 
Published: December 2023

Приводятся способы построения чертежей в евклидовой геометрии и геометрии Лобачевского в процессе конструирования 2-D и 3-D моделей. Сравниваются потенциалы графических редакторов, инструментарий которых предполагает возможность использования метрических измерений в полном изображении. Предлагаются некоторые способы проверки выполненного чертежа при обучении будущих учителей математики решению задач конструктивной геометрии. Делаются выводы о том, что приведенные редакторы эффективны при разработке математических тренажеров по решению задач различных уровней сложности для студентов педагогических вузов.
The methods of constructing drawings in Euclidean geometry and Lobachevsky geometry in the process of constructing 2-D and 3-D models are given. The potentials of graphic editors are compared, the tools of which suggest the possibility of using metric measurements in a full image. Some ways of checking the completed drawing are proposed when teaching future mathematics teachers to solve problems of constructive geometry. Conclusions are drawn that the editors are effective in developing mathematical simulators for solving problems of various levels of complexity for students of pedagogical universities.
An integrative approach to teaching foreign languages: organization of educational and cognitive activities of students in a specialized museum
Authors: Изимариева З.Н. , Мустафина А.Р. , Эделева И.В. , Шпар Т.В. 
Published: December 2023

Статья посвящена применению интегративного подхода при обучении иностранным языкам в неязыковом вузе. Проведен анализ интерактивного внеаудиторного занятия по деловому английскому языку с применением интегративного подхода, организованного в специализированном музее лесоводства для студентов направления подготовки «Лесное дело». Изложены основные этапы организации учебно-познавательной деятельности обучающихся. Описаны виды и формы работ, задействованные в анализируемом мероприятии, предложены рекомендации по организации подобного вида занятий в специализированных музеях. Сформулирован вывод о том, что интегративный подход к обучению иностранным языкам позволяет реализовать межпредметные связи и способствует развитию профессиональных навыков будущих специалистов.
The article is devoted to the application of an integrative approach in teaching foreign languages in a non-linguistic university. An analysis was made of an interactive extracurricular business English lesson using an integrative approach, organized in a specialized museum of forestry for students of the “Forestry” fi eld of study. The main stages of the organization of educational and cognitive activity of students are outlined. The types and forms of work involved in the analyzed event are described, recommendations are made for organizing this type of training in specialized museums. The conclusion is formulated that an integrative approach to teaching foreign languages allows the implementation of interdisciplinary connections and contributes to the development of professional skills of future specialists.
Asynchronous method of course design organization
Authors: Степанов А.Г. , Космачев В.М. , Москалева О.И. 
Published: December 2023

Целью статьи является описание и доказательство эффективности разработанного авторами метода организации курсового проектирования с использованием системы управления обучением. Рассматривается вариант его организации в рамках самостоятельной работы студента. Обсуждаются вопросы академического мошенничества, приводится их авторская классификация и выделяются методы, связанные с копированием готовых текстов и заказом работ в том числе применительно к chatGPT. Фиксируются недостатки текущей организации курсового проектирования в высшей школе с позиций администрации вуза, методистов, студентов и преподавателей. Обсуждается вариант внедрения модульно-рейтинговой системы оценки результатов выполнения курсовых работ на основе рекомендаций различных авторов и отмечаются ее недостатки. Предлагается авторский асинхронный вариант организации курсового проектирования, основанный на последовательном контроле выполнения этапов курсовой работы с использованием Moodle для возврата исполнителю неудовлетворительного варианта составляющих работы. Приводятся результаты выполнения и оценивания курсовых работ по предлагаемой методике.
The purpose of the article is to describe and prove the eff ectiveness of the method developed by the authors for organizing course design using a learning management system. A variant of its organization within the framework of the student’s independent work is considered. The issues of academic fraud are discussed, their author’s classifi cation is given, and the methods associated with copying ready-made texts and ordering works, including in relation to chatGPT, are highlighted. The shortcomings of the current organization of course design in higher education are fi xed from the standpoint of the university administration, methodologists, students and teachers. The option of introducing a module-rating system for evaluating the results of term papers based on the recommendations of various authors is discussed and its shortcomings are noted. The author’s asynchronous version of the organization of course design is proposed, based on the sequential control of the implementation of the stages of the course work using Moodle to return the unsatisfactory version of the work components to the executor. The results of the implementation and evaluation of term papers according to the proposed methodology are given.
Development of technology of socialization-individualization of preschool children in motor activity: theoretical stage
Authors: Павлова Л.И. , Волошина Л.Н. 
Published: December 2023

Приводятся результаты анализа научных подходов к рассмотрению процессов социализации и индивидуализации. Определены основные механизмы их осуществления, специфика в период дошкольного детства. Рассмотрено содержание образовательной деятельности в дошкольных образовательных организациях, нацеленное на поддержку процессов социализации и индивидуализации детей. Выявлены эффективные технологии социализации-индивидуализации дошкольников и потенциал различных видов детской деятельности. Делается вывод о наличии теоретических предпосылок для разработки технологии социализации-индивидуализации детей дошкольного возраста в двигательной деятельности.
The results of the analysis of scientific approaches to the consideration of the processes of socialization and individualization are given. The main mechanisms for their implementation, the specifics in the period of preschool childhood are determined. The content of educational activities in preschool educational organizations, aimed at supporting the processes of socialization and individualization of children, is considered. Effective technologies of socialization-individualization of preschool children and the potential of various types of children’s activities are revealed. The conclusion is made about the presence of theoretical prerequisites for the development of technology of socialization-individualization of preschool children in motor activity.
Theoretical aspects of development of special endurance of cross-country skiers by the method of conjugate influence
Authors: Потапов Ф.С. 
Published: December 2023

Рассматриваются теоретические аспекты развития специальной выносливости лыжников-гонщиков с помощью метода сопряженного воздействия. Показана роль основных физических качеств спортсмена. Раскрывается содержание термина «выносливость» как способности спортсмена превозмогать усталость в рамках реализации мышечной деятельности. Показаны детерминанты развития специальной выносливости (предъявляемые к организму требования, необходимые для реализации определенных упражнений; уровень подготовленности внутренних органов и систем организма (например, вегетативная нервная система); волевые качества спортсмена). Делается вывод о том, что предлагаемый метод сопряженного воздействия эффективен для развития анаэробных возможностей лыжника.
Theoretical aspects of the development of special endurance of cross-country skiers with the help of the conjugate impact method are considered. The role of the main physical qualities of an athlete is shown. The content of the term “endurance” is revealed as the ability of an athlete to overcome fatigue in the framework of the implementation of muscle activity. The determinants of the development of special endurance are shown (requirements for the body necessary for the implementation of certain exercises; the level of preparedness of the internal organs and systems of the body (for example, the autonomic nervous system); volitional qualities of an athlete). It is concluded that the proposed method of conjugate exposure is effective for the development of the anaerobic capabilities of the skier.
Determination of antioxidant activity, total phenolic and total flavonoid contents in tamarillo (Solanum betaceum) peel's ethanolic extracts
Authors: Silitonga Desni Rinanda , Arianto Anayanti , Silalahi Jansen 
Published: December 2023

Background: Free radicals are chemical species a molecule, atom with unpaired electrons and reactive as oxidizing agent which cause oxidize stress in tissue. Antioxidants are substances that can protect cells from free radicals by releasing electrons to neutralize free radicals. Tamarillo peel contains phenolic and flavonoid compounds which have antioxidant activity. The aim of this study was to determine the antioxidant activity, total phenolic and flavonoid content of the ethanol extract of tamarillo peel.
Methods: In this research, the maceration method was used to extract phenolic and flavonoid components from tamarillo peel with ethanol 70% solvent. Total phenolic and flavonoid content was determined with UV-vis spectrophotometer. Total phenolic content determined using the Folin-Ciocalteu reagent and expressed in GAE (Garlic acid equivalent) and the total flavonoid content used the AlCl-3 reagent and expressed in QE (Quersetin equivalent). Then, tamarillo peel ethanol extract was tested the antioxidant activity using the DPPH method.
Result: The results showed that the total polyphenol content was 66.6242 mg GAE/g extract or 6.66% w/v extract, total flavonoid content was 0.74246 % w/v or 7.4246 mg QE/g extract. Antioxidant activity in IC50 value was 47.9460 ppm.
Conclusions: From the results of the research conducted, it can be seen that the ethanol extract of tamarillo can provide an antioxidant effect in the very strong category.
Preference and Utilization of Media Channels as Communication Instruments of Local Public Administrators in Bacolod City, Negros Occidental
Authors: Pascual-Dormido Yasmin 
Published: December 2023

This descriptive study sought to determine the level of preference and extent of utilization of local public administrators (LPAs) of Bacolod City of media channels as communication instruments. Needed data were collected from all 85 middle-level managers holding positions as department head, assistant department head, division chief, and assistant division chiefs in the local government unit (LGU) using a survey questionnaire that has passed both validity and reliability test. Subsequent analyses reveal respondents' level preference and extent of utilization of social media, specifically Facebook and mainstream media (television/radio and newspapers) as information soures and feedback instruments concerning their functions as public administrators. Respondents exhibited a "high level" of preference and a "great extent" of utilization in the above-mentioned areas. Meanwhile, a significant difference was present in demographic variables like age and length of service. There was a significant relationship between the LPA’s level of preference and extent of utilization. It has been established that respondents' preference led to their utilization of a specific medium. These findings call for a review and possible modification of departments’ and divisions' communication strategies for relevance, transparency, and responsiveness.
Una revisión sobre los factores que influyen en la servitización en el contexto de los países emergentes
Authors: Chaihuaque Dueñas Bruno 
Published: December 2023

El objetivo de este artículo es revisar los factores que influyen en la servitización en investigaciones que se hayan realizado tomando como muestra a empresas que operan en países de economías emergentes. A partir de la aplicación del método PRISMA se ha llevado a cabo una revisión sistemática de literatura con la cual se ha podido identificar estos factores, en tanto el fenómeno de la servitización presenta distintas brechas de conocimiento, pero además brechas poblacionales. Es así que la literatura en este campo suele concentrarse en países desarrollados y en aquellos con un desarrollo tecnológico y uso intensivo de tecnología superior al promedio.
Por lo tanto, este artículo lleva a cabo un análisis en un ámbito poblacional específico, que no ha sido abordado en otros estudios. De esta forma, se pretende identificar factores específicos que influyen en la servitización, a partir de los estudios realizados, en un contexto institucional y tecnológico con relieves y matices, pero que se presenta como diferente al de aquellos países desarrollados, de tal manera que sirva para motivar posteriores investigaciones sobre este campo en países emergentes.
En este estudio se han encontrado diferencias y similitudes respecto a la literatura general, y además se ha identifica que dentro de los países emergentes también existen diferencias, principalmente por las distintas bases tecnológicas entre China y el resto de países que conforman este subgrupo.
Analisis Senyapan dan Kilir Lidah pada Produksi Ujaran dalam Acara Ormas
Authors: Davidra Dasril 
Published: December 2023

Setiap manusia sebagai penutur bahasa umumnya pernah mengalami senyapan dan kilir lidah dalam berbicara. Penelitian ini bertujuan untuk menganalisis bentuk senyapan, bentuk dan unit kilir lidah, serta fungsi tuturan ketika seseorang mengalami senyapan dan kilir lidah pada produksi ujaran dalam acara Ormas. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Metode yang digunakan dalam pengumpulan data, yaitu observasi melalui video-video di YouTube. Sumber data penelitian ialah produksi ujaran yang terdapat senyapan dan kilir lidah dalam acara Ormas dari bulan Februari hingga Juli 2023 di kanal YouTube Deddy Corbuzier. Hasil penelitian menunjukkan bahwa terdapat dua bentuk senyapan yang ditemukan, yaitu senyapan diam dan senyapan terisi. Bentuk kilir lidah yang ditemukan terdiri dari dua bentuk, yaitu kekeliruan seleksi dan kekeliruan asembling. Unit kilir lidah yang ditemukan, yaitu kekeliruan suku kata, kekeliruan kata, kekeliruan klausa, dan kekeliruan kalimat. Fungsi tindak tutur yang ditemukan, yaitu asertif, komisif, dan ekspresif.

Kata kunci: Produksi Ujaran, Psikopragmatik, Senyapan dan Kilir Lidah, Tindak Tutur
A Hidden Burden On Public Health: Adolescent Pregnancy And Increased Adverse Perinatal Outcomes
Authors: ENGİNDENİZ Fatma Tuba , SİMSEK Deniz , DİNÇGEZ Burcu 
Published: December 2023

ABSTRACT
Objective: Adolescent pregnancy, associated with increased adverse pregnancy outcomes, is a major public health problem. This study aimed to assess adverse perinatal outcomes in adolescent pregnancies by comparing them with adult pregnancies.
Methods: 1104 adolescent and 2463 adult pregnant women were included. Presence of fetal anomaly, gestational diabetes, preeclampsia-eclampsia, intrauterine growth restriction, intrahepatic cholestasis, polyhydramnios, placenta previa, in utero mort fetus, uterine rupture, placenta abruption, umbilical cord prolapse, acute fetal distress, preterm birth, cesarean section, labor arrest, birth weight, macrosomia, dystocia, birth trauma, APGAR scores, neonatal intensive care unit admission, postpartum hemorrhage, hysterectomy, blood transfusion, and postpartum infection were recorded.
Results: Rates of acute fetal distress, preterm birth, low birth weight, neonatal intensive care unit admission, postpartum hemorrhage, and blood transfusion were higher while birth weight, APGAR scores of fifth minutes, the rates of cesarean section, prolonged and arrested labor, gestational diabetes, and macrosomia were lower in adolescents. In regression analysis, being adolescent pregnant increase the risk of acute fetal distress by 1.4 times (aOR=1.439;95%CI=1.030-2.01, p=0.033), preterm birth by 1.7 times (aOR=1.692; 95%CI=1.104-2.596, p=0.016) and decrease the risk of gestational diabetes (aOR=0.182; 95%CI=0.116-0.286, p
An improved neurogenetic model for recognition of 3D kinetic data of human extracted from the Vicon Robot system
Authors: Stepanyan Ivan V. , Hameed Safa A. 
Published: December 2023

These days, it is crucial to discern between different types of human behavior, and artificial intelligence techniques play a big part in that. The characteristics of the feedforward artificial neural network (FANN) algorithm and the genetic algorithm have been combined to create an important working mechanism that aids in this field. The proposed system can be used for essential tasks in life, such as analysis, automation, control, recognition, and other tasks. Crossover and mutation are the two primary mechanisms used by the genetic algorithm in the proposed system to replace the back propagation process in ANN. While the feedforward artificial neural network technique is focused on input processing, this should be based on the process of breaking the feedforward artificial neural network algorithm. Additionally, the result is computed from each ANN during the breaking up process, which is based on the breaking up of the artificial neural network algorithm into multiple ANNs based on the number of ANN layers, and therefore, each layer in the original artificial neural network algorithm is assessed. The best layers are chosen for the crossover phase after the breakage process, while the other layers go through the mutation process. The output of this generation is then determined by combining the artificial neural networks into a single ANN; the outcome is then checked to see if the process needs to create a new generation. The system performed well and produced accurate findings when it was used with data taken from the Vicon Robot system, which was primarily designed to record human behaviors based on three coordinates and classify them as either normal or aggressive.
Overcoming limitations in current measures of drug response to enable AI-driven precision oncology
Authors: Rapsomaniki Maria Anna , Ovchinnikova Katja , Born Jannis , Chouvardas Panagiotis , de Julio Marianna Kruithof 
Published: December 2023

Abstract

Machine learning (ML) models of drug sensitivity prediction are becoming increasingly popular in precision oncology. Here, we unveil fundamental issues with the use of standard measures of drug sensitivity that hinder the development of personalized prediction models. Our work suggests that using z-scored drug response measures mitigates these issues and leads to meaningful predictions, opening the door for sophisticated ML precision oncology models.
Excellent thermoelectric performance of Full-Heusler Fe2NbAl alloy induced by strong anharmonic rattling and high band degeneracy
Authors: ZHAO Wenyu , Ye Xianfeng , Yu Jian , Ke Shaoqiu , Liang Dong , Chen Tiantian , Liu Chengshan , Xu Wenjie , Li Longzhou , Zhu Wanting , Nie Xiaolei , Wei Ping , Zhang Qingjie 
Published: December 2023

Abstract
Full-Heusler alloys with earth-abundant elements exhibit high mechanical strength and favorable electrical transport behavior, but their high intrinsic lattice thermal conductivity limits potential thermoelectric application. Here, the thermoelectric transport properties of Fe-based Full-Heusler Fe2MAl (M = V, Nb, Ta) alloys are comprehensively investigated utilizing density functional theory. The results suggest that Fe2NbAl exhibits exceptionally low lattice thermal conductivity due to the strong anharmonic scattering induced by weakly bound Fe atoms and the low phonon velocities caused by heavy Nb atoms. Meanwhile, the high band degeneracy and large electrical conductivity lead to a maximum p-type power factor of 255.6 μW·K-2·cm-1 at 900 K. The combination of low lattice thermal conductivity and favorable electrical transport properties results in a maximum p-type dimensionless figure of merit of 1.7. Our work indicates Fe2NbAl, as a low-cost, environmentally friendly compound, is a potential high-performance p-type thermoelectric material.
Application of the improved Probabilistic Fuzzy Logic Inference Engine Model to evaluate Mineralization Prospectivity - Taking the Gejiu region of Yunnan, China as an example
Authors: Jie ZHAO , Yongqing CHEN , Pengda ZHAO , Junhua KU 
Published: December 2023

Abstract
A probabilistic fuzzy logic inference engine simulated by the Monte Carlo method is used to determine the mineralization prospectivity of Sn deposits in the Gejiu region, and the uncertainty of the mineralization prospectivity is evaluated. The elemental analysis of the fuzzy logic inference engine is improved, and the Hilbert-Huang transformation (HHT) multi-scale model is integrated. The copula function is proposed to solve the problem of correlation between elements. The probabilistic fuzzy logic inference engine simulated by the Monte Carlo method can provide more information than the traditional method. Its most significant advantage is that it can describe the potential and uncertainty of data and models, which are caused by random error and fuzziness. This information can be used in the subsequent risk assessment of the exploration targets. It can also determine the largest source of uncertainty in the final mineralization prospectivity map, thereby reducing the uncertainty.