bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering in vernetzten, offenen, durchgängigen Systemen (Engineering in Linked and Open Systems)
Authors: Fay Alexander 
Published: April 2005

Abstract
Der Technologiewandel in der Automatisierungstechnik, insbesondere in der Prozessleittechnik, hat für das Engineering dieser Automatisierungssysteme vielfältige Konsequenzen. Der Beitrag berichtet von der Arbeit des GMA-Fachausschusses 6.12 (bis Ende 2004 FA 6.21), welcher sich mit dafür geeigneten Engineering-Methoden und Werkzeugkonzepten beschäftigt.
Circulating Leukocyte Subsets Before and After a Breast Cancer Diagnosis and Therapy
Authors: Kresovich Jacob K. , O’Brien Katie M. , Xu Zongli , Weinberg Clarice R. , Sandler Dale P. , Taylor Jack A. 
Published: February 2024

ImportanceChanges in leukocyte composition often precede chronic disease onset. Patients with a history of breast cancer (hereinafter referred to as breast cancer survivors) are at increased risk for subsequent chronic diseases, but the long-term changes in peripheral leukocyte composition following a breast cancer diagnosis and treatment remain unknown.ObjectiveTo examine longitudinal changes in peripheral leukocyte composition in women who did and did not develop breast cancer and identify whether differences in breast cancer survivors were associated with specific treatments.Design, Setting, and ParticipantsIn this prospective cohort study, paired blood samples were collected from 2315 women enrolled in The Sister Study, a US-nationwide prospective cohort study of 50 884 women, at baseline (July 2003 to March 2009) and follow-up (October 2013 to March 2015) home visits, with a mean (SD) follow-up interval of 7.6 (1.4) years. By design, approximately half of the included women had been diagnosed and treated for breast cancer after enrollment and before the second blood draw. A total of 410 women were included in the present study, including 185 breast cancer survivors and 225 who remained free of breast cancer over a comparable follow-up period. Data were analyzed from April 21 to September 9, 2022.ExposuresBreast cancer status and, among breast cancer survivors, cancer treatment type (chemotherapy, radiotherapy, endocrine therapy, or surgery).Main Outcomes and MeasuresBlood DNA methylation data were generated in 2019 using a genome-wide methylation screening tool and deconvolved to estimate percentages of 12 circulating leukocyte subsets.ResultsOf the 410 women included in the analysis, the mean (SD) age at enrollment was 56 (9) years. Compared with breast cancer–free women, breast cancer survivors had decreased percentages of circulating eosinophils (−0.45% [95% CI, −0.87% to −0.03%]; P = .03), total CD4+ helper T cells (−1.50% [95% CI, −2.56% to −0.44%]; P = .01), and memory B cells (−0.22% [95% CI, −0.34% to −0.09%]; P = .001) and increased percentages of circulating naive B cells (0.46% [95% CI, 0.17%-0.75%]; P = .002). In breast cancer survivor–only analyses, radiotherapy was associated with decreases in total CD4+ T cell levels, whereas chemotherapy was associated with increases in naive B cell levels. Surgery and endocrine therapy were not meaningfully associated with leukocyte changes.Conclusions and RelevanceIn this cohort study of 410 women, breast cancer survivors experienced lasting changes in peripheral leukocyte composition compared with women who remained free of breast cancer. These changes may be related to treatment with chemotherapy or radiotherapy and could influence future chronic disease risk.
Examining the role of posttraumatic stress disorder symptoms in intimate partner violence among couples with alcohol use disorder
Authors: Flanagan Julianne C. , Hogan Jasara N. , Massa Andrea A. , Jarnecke Amber M. 
Published: February 2024

AbstractSeparate literatures indicate that both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are robust risk factors for using intimate partner violence (IPV). Despite the strength of these relative literatures, and the common co‐occurrence of AUD and PTSD, their combined effects on IPV have rarely been examined. This study begins to address this gap by exploring the moderating effects of provisional PTSD diagnosis on the relation between heavy alcohol consumption and physical IPV using a multilevel modeling approach. Participants were adult romantic couples (N = 100) with current AUD and a history of physical IPV in their relationship. Results from the between‐couple comparison indicate that couples who reported more heavy drinking days also experienced more physical IPV when at least one partner had probable PTSD. However, the within‐couple comparison indicated that among partners without a provisional PTSD diagnosis, those with fewer heavy drinking days compared to their partner also reported more physical IPV perpetration. These preliminary and exploratory findings require replication and extension but provide new and important information regarding the complex intersection of heavy drinking, PTSD, and IPV among couples with AUD.
Implementation of a patient safety training program in radiation oncology residency: A pilot study
Authors: Chowdhury Imran H. , Garg Rashi , Huber Kathryn E. , Stambaugh Nathaniel P. , Stambaugh Cassandra 
Published: February 2024

AbstractPurposeAn educational program using Radiation Oncology‐Incident Learning System (RO‐ILS) was developed to improve safety culture and training for radiation oncology (RO) residents.MethodsThe program included a pre‐training assessment, interactive training, integration of residents into quality assurance meetings, and a post‐training assessment over a 3 month rotation.ResultsTwelve residents completed the safety training program. Pre‐training assessment mean scores (five‐point scale) of experience with Incident Learning Systems (ILS), root‐cause analysis (RCA), failure‐mode and effect analysis (FMEA), safety training, and culture were 2.3, 2.8, 2.0, 4.0, and 4.4, respectively. Post‐training assessment showed a significant increase in ILS 4.0 (p < 0.001), RCA 3.8 (p = 0.008), and FMEA 3.3 (p = 0.006) and safety culture (4.8, p = 0.043). Additionally, residents were anonymously surveyed ≥ 10 months after graduation to determine the long‐term value of the program. The overall assessment from the graduated residents indicates that this education is valued by RO in many institutions. The majority of the residents are either currently utilizing or plan to utilize the information gained in this program in their new institutions.ConclusionsWe report a successful implementation of a safety training program in a RO residency with significant improvements in self‐reported confidence with the concepts of ILS, RCA, and FMEA and an improved perception of safety culture. This program can be implemented across all residency programs.
Synchronously Enhancing Mechanical Strength and Conductivity of MXene Nanofluidic Fibers with Multivalent Ion Crosslinking
Authors: Li Shuo , Yang Zhicheng , Hu Huimin , Wang Junchang , Yang Dongzi , Wang Yizhou , Zhang Liang , Tong Xiaoling , Xia Zhou , Chen Zhihui , Lian Xueyu , Shi Zixiong , Xu Xiangming , Guo Yinben , Alshareef Husam N. , Shao Yuanlong 
Published: February 2024

AbstractDeveloping high‐performance nanofluidic fibers with synergetic ionic and electric conductivities is promising for human–machine interface interaction. In such a scenario, inter‐ and intra‐forces in constituent flakes are recognized as crucial factors in determining the derived nanofluidic fiber performance. In this work, the rheological properties of Ti3C2Tx MXene solution are systematically optimized by regulating the electrostatic interaction via introducing multivalent metal cations. As a result, such multivalent cations trigger ionic crosslinking and remarkably strengthen the interaction force between nanosheets, which even forms into a tight fiber‐shaped gel network. A series of cations, such as K+, Na+, Mg2+, Zn2+, and Al3+, are introduced to enhance the ionic cross‐linking between interconnected flakes. The thus‐prepared Zn2+‐Ti3C2Tx fiber exhibits a remarkable electrical conductivity of 11 200 S cm−1, a tensile strength of 252 MPa, and an ionic conductivity of 2.51 × 10−3 S cm−1. This multivalent cation crosslinking strategy could offer some insights into developing functional nanofluidic fibers for wearable or healthcare applications.
Auger‐Assisted Secondary Hot Carrier Transfer in a Type I MoS2/PtSe2 Heterostructure
Authors: Yang Jin , Gong Shaokuan , Zhang Xiaguang , Liu Jianxun , Luo Wen , Lu Zhouguang , Liu Yanjun , Chen Xihan , Lienau Christoph , Zhong Jin‐Hui 
Published: February 2024

AbstractCharge transfer is vital in determining the optoelectronic properties of atomically thin materials, yet remains elusive in type I heterostructures. Here, distinct two‐step charge transfer processes in a type I MoS2/PtSe2 heterostructure are reported. By exclusively exciting the smaller bandgap PtSe2, strong exciton photobleaching peaks of the larger bandgap MoS2 are observed, indicating primary hot carrier transfer from PtSe2 to MoS2 within 70 fs. More importantly, the amplitude of the exciton peaks shows a secondary increase after the initial rapid decay. These dynamics are distinctly different from the monotonic decrease in monolayer MoS2 and indicate a secondary charge transfer process that is attributed to hot carriers re‐generated in PtSe2 by intralayer Auger recombination. Concurrently, the exciton energy blue shifts within 100 ps, probing the dynamic buildup of a charge‐transfer induced electric field across the heterostructure interface, which displaces electron and hole wavefunctions of MoS2 excitons and reduces the exciton binding energy. The results are corroborated by carrier dynamics and transient absorption spectra simulations by considering the two‐step charge transfer processes. The work reveals Auger‐assisted hot carrier transfer processes in type I heterostructures and suggests the possibility for optoelectronic and photocatalytic applications by optical sub‐bandgap excitation.
Te Cluster Engineering for Tunable Optical Response
Authors: Dong Quan , Huang Yupeng , Chen Jingfei , Zhang Ke , Feng Xu , Li Xueliang , Qiu Jianrong , Zhou Shifeng 
Published: February 2024

AbstractThe construction of active materials with controllable optical response facilitates the development of advanced photonic devices. However, the achievement of robust active materials with wide wavelength tunable and broadband emission remains a great challenge, mainly due to the fixed energy levels of conventional active dopants and limited inhomogeneous broadening in common hosts. Here, the study proposes that the cluster in the mesoscopic scale of ≈1 nm may break this bottleneck issue and demonstrate a strategy for the management of photon emission by engineering the cluster evolution. The amorphous glass as the host to tailor the characteristic configuration of Te clusters from 1 to 2 nm by control of the topological structures in glass is employed. Impressively, it presents a distinct optical response totally different from the conventional active centers and this enables to construct of active photonic glass with continuously tunable emission from 888 to 1064 nm. More importantly, Te cluster‐activated photonic glass fibers are fabricated and the broadband on‐off gain is successfully achieved. Furthermore, benefiting from the unique tunable emission, novel near‐infrared devices are constructed and their application in imaging is demonstrated. The approach of cluster engineering mediated tunable optical response is believed to bring new opportunities for developing advanced photonic devices.
Monolithic Soft Fibrous Valves Capable of Generating Air Pressure Cutoff, Maintaining, and Oscillation for Pneumatic Systems
Authors: Lin Zhonghan , Shao Qi , Du Boyuan , Liu Xin‐Jun , Zhao Huichan 
Published: February 2024

AbstractSoft pneumatic robotics are designed for safe and compliant interaction with the environment or humans. However, the pneumatic systems used for actuation and protection are still relatively bulky and rely on rigid components such as solenoid valves and pressure regulators. This study presents the design and analysis of soft fibrous valves (SFVs) with internal tiny channels and external helical structures, which could be used in soft pneumatic systems. Made from soft material, SFVs demonstrate unique capabilities in controlling pressure by partial expansion under specific pressure. Three types of SFVs are designed: 1) SFV‐C is designed to protect soft pneumatic actuators by cutting off airflow under excessive pressure; 2) SFV‐M maintains pressure in actuators when the input pressure abruptly drops, preventing potential damage to the operated object; 3) SFV‐O produces oscillating pressure output without electronic control supplied by constant pressure source. Theoretical modeling and experimental validations are conducted to investigate the performance of the SFVs under various stretching, twisting, and pressure conditions. Furthermore, fully flexible SFVs are designed to enhance their compliance and resistance to external impacts. Overall, the SFVs offer promising solutions for pressure control and protection in soft pneumatic systems, enabling safer and more effective operations in various scenarios.
Self‐Calibrated Flexible Holographic Curvature Sensor
Authors: Xiao Jianling , Plaskocinski Tomasz , Biabanifard Mohammad , Di Falco Andrea 
Published: February 2024

AbstractOptical curvature sensors find regular use in deformation analysis, typically requiring pre‐calibration and post‐processing of the gathered data. In this work, a self‐calibrated curvature sensor based on flexible holographic metasurfaces operating in the visible range is presented. In contrast to existing solutions, the sensor can be fabricated independently from the target objects and provides an immediate readout of their curvature. The sensor consists of distinct patterned areas that create images of a reference scale and of a position indicator, which shift with respect to each other, as the metasurface is deformed. The results of this sensor are validated with an external calibration and critically discuss the types of deformations that the sensor can detect. This feature makes the sensor particularly attractive for applications where real‐time curvature monitoring is essential, such as in robotics, biomechanics, and structural health monitoring.
Tribovoltaic Effect: Origin, Interface, Characteristic, Mechanism & Application
Authors: Zhang Zhi , Gong Likun , Luan Ruifei , Feng Yuan , Cao Jie , Zhang Chi 
Published: February 2024

AbstractTribovoltaic effect is a phenomenon of the generation of direct voltage and current by the mechanical friction on semiconductor interface, which exhibits a brand‐new energy conversion mechanism by the coupling of semiconductor and triboelectrification. Here, the origin, interfaces, characteristics, mechanism, coupling effect and application of the tribovoltaic effect is summarized and reviewed. The tribovoltaic effect is first proposed in 2019, which has developed in various forms tribovoltaic nanogenerator (TVNG) including metal‐semiconductor, metal‐insulator‐semiconductor, semiconductor‐semiconductor, liquid‐solid and flexible interfaces. Compared with triboelectric nanogenerator, the TVNG has the characteristics of direct‐current, high current density (mA‐A cm−2) and low impedance (Ω‐kΩ). The two mainstream views on the tribovoltaic generation mechanism, one dominated by built‐in electric fields and the other dominated by interface electric fields, have been elaborated and summarized in detail. The tribo‐photovoltaic effect and tribo‐thermoelectric effect are also discovered and introduced because they can easily interact with other multi‐physical field effects. The TVNGs are suitable for making energy harvesting and self‐powered sensing devices for micro‐nano energy applications. This paper not only revisit the development of the tribovoltaic effect, but also makes prospects for mechanism research, device fabrication and integrated application, which can accelerate the evolution of smart wearable electronics and intelligent industrial components.
Concentric Hybrid Nanoelectrospray Ionization‐Atmospheric Pressure Chemical Ionization Source for High‐Coverage Mass Spectrometry Analysis of Single‐Cell Metabolomics
Authors: Xu Tianrun , Li Hang , Dou Peng , Luo Yuanyuan , Pu Siming , Mu Hua , Zhang Zhihao , Feng Disheng , Hu Xuesen , Wang Ting , Tan Guang , Chen Chuang , Li Haiyang , Shi Xianzhe , Hu Chunxiu , Xu Guowang 
Published: February 2024

AbstractHigh‐coverage mass spectrometry analysis of single‐cell metabolomics remains challenging due to the extremely low abundance and wide polarity of metabolites and ultra‐small volume in single cells. Herein, a novel concentric hybrid ionization source, nanoelectrospray ionization‐atmospheric pressure chemical ionization (nanoESI‐APCI), is ingeniously designed to detect polar and nonpolar metabolites simultaneously in single cells. The source is constructed by inserting a pulled glass capillary coaxially into a glass tube that acts as a dielectric barrier layer. Benefitting from the integrated advantages of nanoESI and APCI, its limit of detection is improved by one order of magnitude to 10 pg mL−1. After the operational parameter optimization, 254 metabolites detected in nanoESI‐APCI are tentatively identified from a single cell, and 82 more than those in nanoESI. The developed nanoESI‐APCI is successively applied to study the metabolic heterogeneity of human hepatocellular carcinoma tissue microenvironment united with laser capture microdissection (LCM), the discrimination of cancer cell types and subtypes, the metabolic perturbations to glucose starvation in MCF7 cells and the metabolic regulation of cancer stem cells. These results demonstrated that the nanoESI‐APCI not only opens a new avenue for high‐coverage and high‐sensitivity metabolomics analysis of single cell, but also facilitates spatially resolved metabolomics study coupled with LCM.
Mechanism and kinetics of self‐sensitized photocycloaddition of cyclohexenone and norbornene
Authors: Chen Ying , Zhang Xinfang , Guo Xiaolei , Ai Minhua , Shu Yumei , Shi Chengxiang , Zhang Xiangwen , Zou Ji‐Jun , Pan Lun 
Published: February 2024

AbstractSolar‐driven conversion of renewable biomass resources into high‐density hydrocarbon fuels can effectively realize biomass valorization and renewable energy conversion. In this work, an efficient self‐sensitized [2 + 2] photocycloaddition process is explored to develop highly strained fuel with high yield using norbornene and biomass‐derived cyclohexenone as feedstocks. The enhancement mechanism is revealed by phosphorescent measurement and theoretical calculation, and a reasonable reaction path for self‐sensitized [2 + 2] co‐cycloaddition is proposed. When using methanol as solvent, the apparent activation energy of co‐cycloaddition is 21.37 W/mol, which is lower than that of self‐cycloaddition (31.57 W/mol). Importantly, the jet‐fuel‐range highly strained fuel has high density (0.986 g/cm3) and high volumetric net heat of combustion (41.14 MJ/L), which are 5.34% and 4.39% higher than those of JP‐10, respectively. This work proposes a green and effective pathway for the preparation of high‐performance hydrocarbon fuel with polycyclic‐asymmetric structure.
PRKACA‐related, atrial defects‐polydactyly‐multiple congenital malformation syndrome in an Indian patient
Authors: Sithambaram Sivagamy , Jacob Prince , Neethukrishna Kausthubham , Bhavani Gandham SriLakshmi , Dalal Ashwin , Shah Hitesh , Girisha Katta Mohan 
Published: February 2024

AbstractPRKACA‐related, atrial defects‐polydactyly‐multiple congenital malformation syndrome is a recently described skeletal ciliopathy, which is caused by disease‐causing variants in PRKACA. The primary phenotypic description includes atrial septal defects, and limb anomalies including polydactyly and short limbs. To date, only four molecularly proven patients have been reported in the literature with a recurrent variant, c.409G>A p.Gly137Arg in PRKACA. In this study, we report the fifth affected individual with the same variant and review the clinical features and radiographic findings of this rare syndrome.
The dementia care study (D‐CARE): Recruitment strategies and demographic characteristics of participants in a pragmatic randomized trial of dementia care
Authors: Yang Mia , Samper‐Ternent Rafael , Volpi Elena , Green Aval‐Na'Ree , Lichtenstein Maya , Araujo Katy , Borek Pamela , Charpentier Peter , Dziura James , Gill Thomas M. , Galloway Rebecca , Greene Erich J. , Lenoir Kristin , Peduzzi Peter , Meng Can , Reese Jordan , Shelton Amy , Skokos Eleni A. , Summapund Jenny , Unger Erin , Reuben David B. , Williamson Jeff D. , Stevens Alan B. 
Published: February 2024

AbstractINTRODUCTIONPragmatic research studies that include diverse dyads of persons living with dementia (PLWD) and their family caregivers are rare.METHODSCommunity‐dwelling dyads were recruited for a pragmatic clinical trial evaluating three approaches to dementia care. Four clinical trial sites used shared and site‐specific recruitment strategies to enroll health system patients.RESULTSElectronic health record (EHR) queries of patients with a diagnosis of dementia and engagement of their clinicians were the main recruitment strategies. A total of 2176 dyads were enrolled, with 80% recruited after the onset of the pandemic. PLWD had a mean age of 80.6 years (SD 8.5), 58.4% were women, and 8.8% were Hispanic/Latino, and 11.9% were Black/African American. Caregivers were mostly children of the PLWD (46.5%) or spouses/partners (45.2%), 75.8% were women, 9.4% were Hispanic/Latino, and 11.6% were Black/African American.DISCUSSIONHealth systems can successfully enroll diverse dyads in a pragmatic clinical trial.
Total Synthesis of Dragocins A−C through Electrochemical Cyclization
Authors: Smith Brendyn P. , Truax Nathanyal J. , Pollatos Alexandros S. , Meanwell Michael , Bedekar Pranali , Garrido‐Castro Alberto F. , Baran Phil S. 
Published: February 2024

AbstractThe first total synthesis of dragocins A−C, remarkable natural products containing an unusual C4’ oxidized ribose architecture bridged by a polyhydroxylated pyrrolidine, is presented through a route featuring a number of uncommon maneuvers. Several generations towards the target molecules are presented, including the spectacular failure of a key C−H oxidation on a late‐stage intermediate. The final route features rapid, stereocontrolled access to a densely functionalized pyrrolidine and an unprecedented diastereoselective oxidative electrochemical cyclization to forge the hallmark 9‐membered ring. Preliminary studies suggest this electrochemical oxidation protocol is generally useful.
Building on Community Connections to Foster Environmental Justice
Authors: Dunn Alexandra Dapolito , Wettengel Jeffrey , Fader Zachary 
Published: February 2024

Key TakeawaysEnvironmental justice is a significant community and social movement that continues to evolve.As “anchor infrastructure,” water utilities are in a good position to meet this movement, using their relationships within their communities and experience with navigating complex issues.New funding sources and “environmental big data” are opportunities for water utilities to improve their infrastructure and better protect public health in underserved communities.