bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of varices but not anticoagulation is associated with improved outcome in patients with HCC and macrovascular tumour invasion
Authors: Balcar Lorenz , Mrekva Arpad , Scheiner Bernhard , Pomej Katharina , Meischl Tobias , Mandorfer Mattias , Reiberger Thomas , Trauner Michael , Tamandl Dietmar , Pinter Matthias 
Published: January 2024

Abstract
Background & aims
The value of bleeding prophylaxis and anticoagulation in patients with hepatocellular carcinoma (HCC) and macrovascular tumour invasion (MVI) is unclear. We evaluated the impact of anticoagulation on thrombosis progression, bleeding events, and overall mortality, and assessed the efficacy of adequate management of varices as recommended for patients with cirrhosis.

Methods
HCC patients with MVI who had Child-Turcotte-Pugh A-B7 were included between Q4/2002 and Q2/2022. Localization of the tumour thrombus and changes at 3–6 months were evaluated by two radiologists. Univariable and multivariable logistic/Cox regression analyses included time-dependent variables (i.e., anticoagulation, systemic therapy, non-selective beta blocker treatment).

Results
Of 124 patients included (male: n = 110, 89%), MVI involved the main portal vein in 47 patients (38%), and 49 individuals (40%) had additional non-tumorous thrombus apposition. Fifty of 80 patients (63%) with available endoscopy had varices. Twenty-four individuals (19%) received therapeutic anticoagulation and 94 patients (76%) were treated with effective systemic therapies. The use of therapeutic anticoagulation did not significantly affect the course of the malignant thrombosis at 3–6 months. Systemic therapy (aHR: 0.26 [95%CI: 0.16–0.40]) but not anticoagulation was independently associated with reduced all-cause mortality. In patients with known variceal status, adequate management of varices was independently associated with reduced risk of variceal bleeding (aHR: 0.12 [95%CI: 0.02–0.71]). In the whole cohort, non-selective beta blockers were independently associated with reduced risk of variceal bleeding or death from any cause (aHR: 0.69 [95%CI: 0.50–0.96]).

Conclusion
Adequate bleeding prophylaxis and systemic anti-tumour therapy but not anticoagulation were associated with improved outcomes in patients with HCC and MVI.
Traumatic instability in the knee joint due to an anterior cruciate ligament (ACL) injury in a 23-year-old athlete
Authors: Taborska Nina , Martyka Anna , Kubicka-Figiel Martyna 
Published: January 2024

Introduction
In this paper, we aim to present an analysis of the diagnostic, therapeutic, and rehabilitation procedures in a 23-year-old athlete with an anterior cruciate ligament (ACL) injury. The study includes the patient's medical history, circumstances of the injury, diagnostic and therapeutic procedures applied, as well as the course of postoperative rehabilitation.
Objective
The objective of our study is to present the anatomy of the ACL, the typical mechanism of injury, and diagnostic and therapeutic possibilities.
Methods
This is a retrospective study. The medical documentation and imaging studies were subjected to analysis. The analysis was complemented by a literature review based on publications in the English-language PubMed database.
Results
The case involves a 23-year-old soccer player with an isolated ACL injury in the right knee joint. The case analysis highlights the challenges related to diagnosis and decision-making regarding therapeutic procedures. ACL reconstruction using the STG method and lateral tenodesis with the iliotibial band in combination with postoperative rehabilitation resulted in a positive outcome in terms of knee joint stability and return to sports.
Conclusions
The review of this medical case underscores the importance of a personalized approach to each patient with an ACL injury, taking into account age, level of physical activity, and coexisting injuries within the knee joint. This allows for the correct decision on the best treatment method for the patient, facilitating a return to sports and minimizing the risk of complications.
The impact of ashwagandha on sleep quality, anxiety reduction, and stress lowering: comparative analysis of available studies
Authors: Malec Klaudia 
Published: January 2024

Introduction and objective: The increasing prevalence of sleep disorders, anxiety, and stress in contemporary society necessitates effective and accessible treatments. Ashwagandha - Withania somnifera (WS), an adaptogenic herb utilized in traditional Ayurvedic medicine, has gained significant attention in recent years for its potential to improve various aspects of health and well-being. This comprehensive review of the scientific literature aims to systematize the current scientific reports regarding the impact of Ashwagandha on enhancing sleep quality, reducing levels of anxiety and stress.

Material and Method: In this article, a review of publications available in the PubMed and Google Scholar databases was conducted, with an analysis of clinical and experimental studies focusing on methodology, participant demographics, dosage regimens, and tools for assessing sleep quality, anxiety, and stress levels. Articles were searched using English language terms: "ashwagandha," "Withania somnifera," "influence of sleep quality," "stress," "anxiety."

Conclusions: The scientific studies presented indicate the benefits of Ashwagandha supplementation in the context of improving sleep quality, reducing anxiety states, and stress. The results of various studies, including randomized controlled trials and systematic reviews, suggest that Ashwagandha may positively influence these health aspects through its action on the hypothalamic-pituitary-adrenal (HPA) axis11, modulation of neurotransmitters (GABA, serotonin)1, and antioxidative activity2.
Supporting healthcare assistants in the workplace
Authors: Nazarko Linda 
Published: January 2024

NHS and social care employers are ‘facing the greatest workforce crisis in their history’, with staff turnover reported to be 11% in the NHS and 29% in social care. This understaffing affects the quality of patient care. Providing healthcare assistants (HCAs) with appropriate support will reduce staff turnover. This sets off a beneficial cycle of reduced pressure because of improved staffing and increased job satisfaction because of ability to deliver better care. Employers can deploy a range of tactics to improve life for HCAs, starting with an excellent induction and continuing with excellent training for career progression.
An automatic analysis and quality assurance method for lymphocyte subset identification
Authors: Zhang MinYang , Zhang YaLi , Zhang JingWen , Zhang JiaLi , Gao SiYuan , Li ZeChao , Tao KangPei , Liang XiaoDan , Pan JianHua , Zhu Min 
Published: January 2024

Abstract

Objectives
Lymphocyte subsets are the predictors of disease diagnosis, treatment, and prognosis. Determination of lymphocyte subsets is usually carried out by flow cytometry. Despite recent advances in flow cytometry analysis, most flow cytometry data can be challenging with manual gating, which is labor-intensive, time-consuming, and error-prone. This study aimed to develop an automated method to identify lymphocyte subsets.

Methods
We propose a knowledge-driven combined with data-driven method which can gate automatically to achieve subset identification. To improve accuracy and stability, we have implemented a Loop Adjustment Gating to optimize the gating result of the lymphocyte population. Furthermore, we have incorporated an anomaly detection mechanism to issue warnings for samples that might not have been successfully analyzed, ensuring the quality of the results.

Results
The evaluation showed a 99.2 % correlation between our method results and manual analysis with a dataset of 2,000 individual cases from lymphocyte subset assays. Our proposed method attained 97.7 % accuracy for all cases and 100 % for the high-confidence cases. With our automated method, 99.1 % of manual labor can be saved when reviewing only the low-confidence cases, while the average turnaround time required is only 29 s, reducing by 83.7 %.

Conclusions
Our proposed method can achieve high accuracy in flow cytometry data from lymphocyte subset assays. Additionally, it can save manual labor and reduce the turnaround time, making it have the potential for application in the laboratory.
Structural assessment of 40 ft mini LNG ISO tank: Effect of structural frame design on the strength performance
Authors: Purnamasari Dian , Tuswan Tuswan , Muttaqie Teguh , Sandjaja Irfan Eko , Machfudin Andik , Rizal Nandiko , Rahadi Shinta Johar Alif , Sasmito Agus , Zakki Ahmad Fauzan , Mursid Ocid 
Published: January 2024

Abstract
Due to the escalating demand for liquefied natural gas (LNG) as a low-emission and environmentally friendly energy source, ISO tank containers have emerged as an innovative solution to facilitate efficient and cost-effective mass transportation. The 40 ft ISO tank container, which encompasses a pressure vessel structure, is a versatile intermodal unit that seamlessly integrates into sea and land transportation networks. The main objective of this study is to present a comprehensive analysis for assessing the various frame design scenarios of the 40 ft ISO tank container for mini LNG carrier operation. The assessment is conducted under the provisions outlined in ASME Section VIII Division I code, which governs the design standards for boilers and pressure vessels. The finite-element analysis (FEA) scrutinizes three different structural design alternatives: frame thickness, the addition of support plates, and the addition of saddle supports, which are subjected to various loading conditions: stacking, lifting, and racking load tests. The analysis offers a comparative assessment of the safety level provided by the ASME design guidance in contrast to the FEA judgments based on ISO standards. It can be found that stacking and longitudinal load tests are more critical operational load scenarios. Increasing the frame thickness of the LNG ISO tank is more practical in increasing structural weight savings than adding more saddle supports and support plates.
CIQBCP-MIMO-DRA: CSRR inspired quad band circularly polarized MIMO-DRA for W-LAN, Wi-Max, Wi-Fi (6E) and X-band applications
Authors: Rath Satyanarayan , Kochuthundil Lalitha Sheeja 
Published: January 2024

Abstract
This paper emphasizes on amalgamation of MIMO antenna with DRA structures; explicitly useful to wireless applications. The feeding mechanism is accomplished by the symmetrically positioned tapered Y-shape lines. The design also encompasses a CSRR geometry along with two metallic reflectors. The incorporation of CSRR introduces novel investigation into traditional designs, resulting in improved isolation performance of the MIMO design. In order to demonstrate the effectiveness of the mentioned antenna, we performed a simulation using ANSYS-HFSS. Subsequently, a physical model was developed and tested. It confirms four different resonating points as 2.56, 4.08, 5.76, and 9.12 GHz with isolations of 36, 47.3, 33.9, and 33 dB respectively. In addition, a few other important parameters relevant to MIMO have been considered and presented in the form of ECC, MEG, DG, CCL, and TARC which claim the dominancy of the stated antenna under the MIMO diversity scenario. In summary, we have presented a model that demonstrates a strong correlation between the simulated and measured outcomes.
Brandt’s Hedgehog, Paraechinus hypomelas (Brandt, 1836), new to the mammal fauna of Iraq
Authors: Al-Sheikhly Omar F. , Ahmed Soran H. , Majeed Soma I. , Kryštufek Boris , Yusefi Gholam H. , Ararat Korsh 
Published: January 2024

Abstract
Due to the wide distribution through the Iranian Plateau, especially in its western parts adjacent to Iraq’s northeastern borders, the occurrence of Brandt’s Hedgehog Paraechinus hypomelas (Brandt, 1836) was suspected, but no confirmed records were made. In 2021–2023, several sightings were obtained during in situ surveys in the Bamo-Khoshk Mountains in the Kurdistan region-northeastern Iraq which confirm the first occurrence of this species in the country.
Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
Authors: Liang ChaoYing , Huang CuiYan , Nong ZhenRu , Li SongLiang , Lin MinShi , Qin ZuYe 
Published: January 2024

Abstract
This study investigated the relationship between ATP-binding cassette sub-family B member 1 (ABCB1) and OLIG2 single nucleotide polymorphism (SNP) and neurological injury severity and outcome in cerebral infarction (CI). The neurological injury severity of 298 CI patients was evaluated by the National Institutes of Health Stroke Scale. The prognosis of CI patients at 30 days after admission was evaluated by the modified Rankin Scale. And 322 healthy people were selected as the control group. The SNPs of the ABCB1 gene (rs1045642) and OLIG2 gene (rs1059004 and rs9653711) were detected by TaqMan probe PCR, and the distribution of SNPs genotype was analyzed. SNP rs9653711 was correlated with CI. Recessive models of rs1045642 and rs9653711 were correlated with CI. The genotypes of rs1045642 and rs9653711 and genetic models were associated with CI severity. rs1045642 had no correlation with CI prognosis, while rs9653711 had less correlation. The genotype distribution and recessive model were associated with CI prognosis. SNP rs1059004 was not associated with CI severity and prognosis. Alcohol consumption, hypertension, diabetes, hyperlipidemia, and high levels of homocysteine (HCY) were independent risk factors for CI, while hypertension, hyperlipidemia, and HCY were associated with poor prognosis of CI. ABCB1 rs1045642 and OLOG2 rs9653711 are associated with CI severity.
Electronic transparency of internal interfaces in metallic nanostructures comprising light, heavy and ferromagnetic metals measured by terahertz spectroscopy
Authors: Beermann Nicolas S. , Fabretti Savio , Hafez Hassan A. , Syskaki Maria-Andromachi , Kononenko Iryna , Jakob Gerhard , Kläui Mathias , Turchinovich Dmitry 
Published: January 2024

Abstract
We investigate the electronic transport at the internal interface within a selection of metallic bilayer nanostructures using the contact-free, all-optical method of THz time-domain spectroscopy. The Ru/Co, Ru/Pt, and Ru/Al bilayer nanostructures and their individual constituent metals are studied, with Ru representing an archetypal d-band metal, Co an archetypal ferromagnet, and Pt and Al archetypal heavy and light metals, respectively. The THz conductivity data were analyzed in terms of Drude and Bloch–Grüneisen models, and the interface current coefficient of the internal nanointerface was determined. Strong temperature dependency of the interface current coefficient in the Ru/Co nanostructure is revealed.
Resonant third-harmonic generation driven by out-of-equilibrium electron dynamics in sodium-based near-zero index thin films
Authors: Silvestri Matteo , Sahoo Ambaresh , Assogna Luca , Benassi Paola , Ferrante Carino , Ciattoni Alessandro , Marini Andrea 
Published: January 2024

Abstract
We investigate resonant third-harmonic generation in near-zero index thin films driven out-of-equilibrium by intense optical excitation. Adopting the Landau weak coupling formalism to incorporate electron–electron and electron–phonon scattering processes, we derive a novel set of hydrodynamic equations accounting for collision-driven nonlinear dynamics in sodium. By perturbatively solving hydrodynamic equations, we model third-harmonic generation by a thin sodium film, finding that such a nonlinear process is resonant at the near-zero index resonance of the third-harmonic signal. Thanks to the reduced absorption of sodium, we observe that third-harmonic resonance can be tuned by the impinging pump radiation angle, efficiently modulating the third-harmonic generation process. Furthermore, owing to the metallic sodium response at the pump optical wavelength, we find that the third-harmonic conversion efficiency is maximised at a peculiar thin film thickness where evanescent back-reflection provides increased field intensity within the thin film. Our results are relevant for the development of future ultraviolet light sources, with potential impact for innovative integrated spectroscopy schemes.
Crystal structure of aqua-octakis(μ
3-salicylato)-(1,10-phenanthroline)-(acetonitrile)-dicobalt(II)-trititanium(IV), C70H45N3O25Co2Ti3
Authors: Zhang Pu , Yu You-Zhu 
Published: January 2024

Abstract
C70H45N3O25Co2Ti3, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 12.7748(10) Å, b = 14.7615(11) Å, c = 18.8142(14) Å, α = 99.929(4)°, β = 92.995(4)°, γ = 109.170(4)°, V = 3278.3(4) Å3, Z = 2, R
gt(F) = 0.0383, wRref
(F
2) = 0.1201, T = 296(2) K.
Robust passivity-based nonlinear controller design for bilateral teleoperation system under variable time delay and variable load disturbance
Authors: Uyulan Caglar 
Published: January 2024

AbstractThis research focuses on implementing a robust passivity-based nonlinear control method for bilateral/teleoperation systems. The key challenge is addressing communication pathways between the master and slave, control delays, and load disturbances, which can lead to instability and reduced transparency. To tackle these issues, the proposed controller incorporates a second-order super-twisting sliding-mode observer to counteract communication and control delays. A sliding mode assist disturbance observer compensates for load torque variations. The approach aims to ensure stability and transparency by handling time-varying delays. The system model comprises two interconnected direct-drive motors, simulating robotic configurations without a physical robot. The nonlinear controller framework simplifies the complex bilateral control problem, significantly improving stability and transparency performance. Computer simulations with step and sinusoidal inputs demonstrate the effectiveness of the approach, providing a satisfactory level of accuracy and transparency between estimated and actual slave positions, even with varying delays and load variations. The research contributes to control engineering by offering a robust method to enhance bilateral system performance, ensuring stable and transparent communication between the master and slave, particularly suitable for real-time internet-based bilateral control systems.
Electrokinetic energy conversion of nanofluids in porous microtubes with Green’s function
Authors: Gao Xue , Zhao Guangpu , Zhang Ying , Zhang Yue 
Published: January 2024

Abstract
Micro-devices fabrication has led to extensive scientific research on microfluidics and microelectromechanical systems. These devices are used for a wide range of technological applications, but research on microfluidic devices for nanofluids is relatively scarce. In response to this problem, the electrokinetic energy conversion (EKEC) efficiency of nanofluids is provided under the coupling effect of pressure gradient and magnetic field through porous microtubes using the Debye–Hückel linearization and the Green’s function method. The results show that the periodic excitation of the square waveform is more effective in increasing the EKEC efficiency. In addition, compared with previous studies, the average velocity is in good agreement with the cosine waveform at R = 0.2. It is worth noting that compared to cosine waves, the average velocity reaches 47% in triangular waves and 85% in square waves.
Latest research progress of SiCp/Al composite for electronic packaging
Authors: Yu Hong , Jiaqin Liu , Yucheng Wu 
Published: January 2024

Abstract
With the rapid development, microelectronic technology has put forward strict requirements for electronic packaging materials (EPMs). SiCp/Al composites with high volume fraction of SiC has become an ideal candidate for EPMs due to their superior properties including high thermal conductivity, tailorable coefficient of thermal expansion as well as low density in many fields. This study reviewed the manufacturing process of SiCp/Al composites in recent years. In addition, the interface between particle and matrix, the application, and the development trend of SiCp/Al composites has also been summarized.
External Filtered Modes of a Quantum Dot Laser Under the Influence of Double-Filtered Optical Feedback
Authors: Mahdi Alaa S. , Husseini Hussein B. Al 
Published: January 2024

When semiconductor lasers SLs are exposed to filtered optical feedback (FOB), they behave in two different ways. Under weak or strong feedback, the first is a singularly stable longitudinal mode with a small linewidth. The second is the so-called coherence breakdown condition, which also includes low frequency fluctuations (LFF) and chaotic oscillations. The latter has received a lot of attention recently due to the possible uses of chaotic lasers in chaotic lidar, covert communications, and chaotic correlation time-domain optical reflectometers, while the former has received a lot of research in recent years. We investigate the behavior of a quantum dot (QD) semiconductor laser subject to FOF from two separate external cavities both, numerically and experimentally. Our findings show that the second FOF allows for rich adjustment of the laser frequency. Our analysis of double-filtered optical feedback (DFOF) lasers is on fundamental solutions, sometimes referred to as continuous waves (CW) or external filtering modes (EFM), which result in a QD laser output with constant amplitude and frequency. The time delay suppression is dependent on the spectral width of the filter and how far it is from the solitary laser frequency, according to numerical calculations.
Wątpliwości na tle Strategii na rzecz Osób z Niepełnosprawnościami 2021-2030
Authors: Bonusiak Ewa 
Published: January 2024

Uchwalona przez Radę Ministrów polska Strategia na rzecz Osób z Niepełnosprawnościami 2021-2030 stanowi istotny dokument kształtujący politykę i działania na rzecz osób z niepełnosprawnościami. Jej głównym celem jest zapewnienie uprawnionym osobom pełnego uczestnictwa w życiu społecznym i poprawę jakości życia. Niniejszy artykuł zwraca uwagę na kilka kluczowych wątpliwości, które mogą wpłynąć na skuteczność i realizację tej Strategii. Wskazuje między innymi na kluczowy instrument realizacji celów strategii jakim jest projekt ustawy o wyrównywaniu szans, która zapewni ramy prawne i narzędzia potrzebne do osiągnięcia celów Strategii.
Manifiesto Universal Sobre Iniciación Científica - MUSIC
Authors: Daza-Orozco Carlos Eduardo , Norman-Acevedo Eduardo , Caro-Gómez Claudia Lucía , Cera-Ochoa Raúl Antonio , Arias-Velandia Nicolás , Mojica-Montoya Fernanda Lucy , Bernal-Llanos Merly María , Acosta-Triviño Ricardo 
Published: January 2024

Iniciación Científica como organización promotora de acciones y estrategias interinstitucionales para la gestión de la cultura científica, tecnológica y creativa; a partir de la formación, implementación, producción y comunicación de procesos de investigación, desarrollo, arte e innovación; luego de la implementación de mesas y equipos de trabajo en diversas disciplinas e Instituciones de Educación Superior en Colombia; tienen el honor de presentar el Manifiesto Universal Sobre Iniciación Científica – MUSIC, una declaración voluntaria y de acción colectiva entorno a la promoción de conocimientos, actitudes y prácticas para la formación de nuevos investigadores.
Si deseas firmar la iniciativa ingresa a: https://iniciacioncientifica.com/manifiesto/ Sección: Firma