bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond digital populism: civic culture and visions of political participation among Five Star Movement activists
Authors: Bedock Camille , Cappellina Bartolomeo 
Published: November 2023

AbstractThis article deals with the impact of intra-party transformations and access to power on the visions of political participation of activists taking part in populist anti-establishment parties with a strong emphasis on digital participation, using the Five Star Movement (M5S) as a case study. Going beyond studies conceiving the M5S as a populist and digital party, we argue that activists support a democratic ideal based on a civic culture involving a demanding role for ordinary citizens, who should be highly interested in politics and involved locally on a day-to-day basis. A negative vision of the Italian citizen judged as incapable of playing this role accompanies this ideal. Our article also demonstrates how political involvement in the M5S transformed the visions of activists, making them warier of direct democracy and more disillusioned about their fellow citizens. The analysis relies on qualitative semi-directed interviews with former and current M5S activists with diversified socio-demographics, political and participation trajectories in two Italian regions. More broadly, our article shows that the effects of entering government and intra-party reforms reinforcing the leadership at the expense of local activists are particularly strong in anti-establishment parties and clash with the conceptions of participation supported by activists.
How Ethnic Origin Shapes Political Preferences: Toward a Deeper Understanding of Asian American Identity
Authors: Yeung Yat To 
Published: November 2023

AbstractHow do Asian Americans think about their ethnic origin? How do ethnic identities affect political preferences? Drawing on interviews with a diverse group of Asian Americans, I provide a nuanced understanding of how they think about their ethnic origin and pan-ethnic identities. The findings reveal that ethnicity plays a significant role in shaping electoral preferences, as Asian Americans exhibit coethnicity preferences, conditional on partisanship. Moreover, I uncover several factors that have been underexplored in the existing literature, including transnational ties, news consumption, and political preferences on foreign policies related to their home country. This article provides a more comprehensive and nuanced understanding of Asian American identities by showing that the ethnic origin roots of Asian Americans can have significant influence on their political interests and candidate preferences.
The role of rigid laryngo-tracheo-bronchoscopy in children with obstructive sleep apnoea: a case series of 65 children
Authors: Dritsoula Aikaterini , Clarke Raymond , Hatziagorou Elpis , Triaridis Stefanos , Talimtzi Persefoni , Elphick Heather 
Published: November 2023

AbstractObjectiveTo assess the role of laryngo-tracheo-bronchoscopy in children with obstructive sleep apnoea by identifying airway abnormalities at surgery, that occur separately or in addition to adenotonsillar hypertrophy, and examining the correlation with respiratory parameters.MethodsA retrospective study was conducted of children with obstructive sleep apnoea who underwent laryngo-tracheo-bronchoscopy intra-operatively, performed by a single ENT surgeon from February 2016 to July 2019. Pre- and post-operative minimum oxygen saturation, apnoea-hypopnoea index, and oxygen desaturation index were recorded.ResultsSixty-five children were identified; 34 were aged less than three years and 31 were aged three years or more. 77 per cent and 13 per cent respectively had an airway abnormality; the t-test showed a significantly higher mean oxygen desaturation index and lower mean minimum oxygen saturation pre-operatively compared to children without an airway abnormality.ConclusionAn update of the surgical pathway for children aged less than three years with obstructive sleep apnoea is required to include laryngo-tracheo-bronchoscopy intra-operatively. A t-test analysis of the pre-operative respiratory parameters suggests that airway abnormalities contribute to obstructive sleep apnoea severity.
Changes in audiovestibular handicap following treatment of vestibular schwannomas
Authors: Campbell Tim , Goh Shao Jie , Wadeson Andrea M , Freeman Simon R , Rutherford Scott A , King Andrew T , Hammerbeck-Ward Charlotte L , Pathmanaban Omar , Entwistle Helen , Bird Judith , Axon Patrick R , Moffat David A , Lloyd Simon K 
Published: November 2023

AbstractObjectiveThis study aimed to assess degree of audiovestibular handicap in patients with vestibular schwannoma.MethodsAudiovestibular handicap was assessed using the Hearing Handicap Inventory, Tinnitus Handicap Inventory and Dizziness Handicap Inventory. Patients completed questionnaires at presentation and at least one year following treatment with microsurgery, stereotactic radiosurgery or observation. Changes in audiovestibular handicap and factors affecting audiovestibular handicap were assessed.ResultsAll handicap scores increased at follow up, but not significantly. The Tinnitus Handicap Inventory and Dizziness Handicap Inventory scores predicted tinnitus and dizziness respectively. The Hearing Handicap Inventory was not predictive of hearing loss. Age predicted Tinnitus Handicap Inventory score and microsurgery was associated with a deterioration in Dizziness Handicap Inventory score.ConclusionAudiovestibular handicap is common in patients with vestibular schwannoma, with 75 per cent having some degree of handicap in at least one inventory. The overall burden of handicap was, however, low. The increased audiovestibular handicap over time was not statistically significant, irrespective of treatment modality.
Faith as skill: an essay on faith in the Abrahamic tradition
Authors: Khalaj M. Hosein M. A. 
Published: November 2023

AbstractWhat is the nature of religious faith as understood in the Abrahamic tradition? This article suggests a novel answer to this question. To this end, I first outline five desiderata, characterized by appealing to conceptions of faith in both the Islamic and Christian traditions, which I think every adequate account of faith should satisfy. These five desiderata are: (1) explaining the principle of the relationship between faith and religious actions; (2) accounting for the maxim of the relationship between faith and moral virtues; (3) showing how the thesis of the priority of faith over knowledge can be the case; (4) providing a basis for the axiom of the gradability of faith; and (5) solving the dilemma of faith as a gift or an achievement. Then I make my case and develop a model of faith that satisfies all five desiderata. Following the accounts in the literature that describes faith as a kind of know-how, the central idea of my suggestion is that religious faith is partly constituted by intellectual, practical, and moral skills.
Adaptive learning with artificial barriers yielding Nash equilibria in general games
Authors: Hassan Ismail , Oommen B. John , Yazidi Anis 
Published: November 2023

Abstract
Artificial barriers in Learning Automata (LA) is a powerful and yet under-explored concept although it was first proposed in the 1980s. Introducing artificial non-absorbing barriers makes the LA schemes resilient to being trapped in absorbing barriers, a phenomenon which is often referred to as lock in probability leading to an exclusive choice of one action after convergence. Within the field of LA and reinforcement learning in general, there is a sacristy of theoretical works and applications of schemes with artificial barriers. In this paper, we devise a LA with artificial barriers for solving a general form of stochastic bimatrix game. Classical LA systems possess properties of absorbing barriers and they are a powerful tool in game theory and were shown to converge to game’s of Nash equilibrium under limited information. However, the stream of works in LA for solving game theoretical problems can merely solve the case where the Saddle Point of the game exists in a pure strategy and fail to reach mixed Nash equilibrium when no Saddle Point exists for a pure strategy.
Furthermore, we provide experimental results that are in line with our theoretical findings.
Analysis of Blanketing Sporadic‐E Layer and Associated Tidal Periodicities Over a Brazilian Station Undergoing a Transition From Low Latitude to Midlatitude
Authors: Moro J. , Xu J. , Bageston J. V. , Denardini C. M. , Andrioli V. F. , Resende L. C. A. , Da Silva L. A. , Li H. , Liu Z. , Wang C. , Schuch N. J. 
Published: November 2023

AbstractAnalyses on a complete year of Digisonde data are conducted to investigate the sporadic‐E (Es) layers over Santa Maria (29.7°S, 53.8°W, dip lat.: −37°), Brazil. This region is undergoing a transition from low latitude to midlatitude within the South American Magnetic Anomaly (SAMA), which provides a key motivation to explore their behavior and the associated tidal periodicities. The Es are classified into four types: flat (Esf), low (Esl), high (Esh), and cusp (Esc). The diurnal and seasonal variations of their top (ftEs) and blanketing (fbEs) frequencies and virtual height (h′Es) are examined. The frequency parameters show the presence of intense Es during equinoxes besides summer. It is also remarkable that the higher values of mean h′Es during winter compared to the other seasons during daytime. These observations differ from previous theories about midlatitude Es layers. The diurnal occurrence rates of the Esb types exhibited distinct dependencies on both local time and seasons. The Esh and Esc were observed exclusively during the daytime, with the former dominating the occurrences in all seasons. To investigate any tidal periodicities embedded in the ftEs, fbEs, and h′Es time series, the Lomb‐Scargle technique was employed. The analysis revealed the presence of 24‐, 12‐, 8‐, and 6‐hr periodicities in both fbEs and h′Es when considering the entire year of data. However, when the data are fractioned into seasons, the predominant periodicities were found to be 24‐ and 12‐hr cycles. Furthermore, when considering the different Esb types, the Lomb‐Scargle analysis indicated varying periodicities.
Modeling and Evaluating Power Grid Resilience Under Extreme Space Weather
Authors: Gao Dong‐Xing , Miao Xiao‐Qing , Wang Yan‐Ling , Zhang Qing‐He , Xing Zan‐Yang , Balan Nanan 
Published: November 2023

AbstractThe geomagnetically induced current (GIC) produced during extreme geomagnetic storms can easily lead to large‐scale blackouts in China due to the increase in the scale of its electric power grid. A power grid's resilience is its capability to resist various natural hazards, withstand primary failures, and quickly resume normal operation. To avoid power grid damages, this study developed a resilient power grid, incorporating failure, power flow calculation and recovery models under a uniform induced geoelectric field. We chose a system's performance loss as the resilience evaluation indicator, which intuitively reflected a system's loss under GIC. In addition, the recovery model was optimized using a genetic algorithm, and two resilience improvement measures were proposed. The IEEE‐RTS‐79 system, consisting of 10 generators, 24 buses and 5 transformers, was chosen as an example to verify the feasibility of this study. The results show that the genetic algorithm and optimization measures effectively enhanced the system's resilience indicator and provided a reference for preventing system damages under GIC and quick recovery after possible failures.
The Global Spectrum of Seafloor Morphology on Mid‐Ocean Ridge Flanks Related to Magma Supply
Authors: Tucholke Brian E. , Parnell‐Turner Ross , Smith Deborah K. 
Published: November 2023

AbstractMagma supply likely exerts primary control on seafloor morphology of oceanic crust, but most studies have related morphology to spreading rate. Here we examine global patterns of morphology on mid‐ocean ridge (MOR) flanks in relation to magma supply derived from residual mantle Bouguer gravity anomaly (proxy for relative crustal thickness) and spreading rate. We use multibeam bathymetry to characterize morphology using both qualitative (descriptive) and quantitative approaches, and we compare results to both magma supply and spreading rate. Morphology becomes more isotropic and abyssal hills are more irregular and discontinuous as magma supply decreases, while roughness, area of steeper slopes, and anomalous fabric orientation increase. We interpret these changes to reflect changing magma distribution along‐axis, from large‐volume and spatially extensive to progressively reduced, increasingly localized, and more irregularly emplaced. Observed relations between crustal thickness and morphology imply that average thickness of purely magmatic crust in the Atlantic and parts of the Indian ridge system is significantly less than average seismically determined crust. Thus seismically defined crustal thickness in those regions likely includes significant non‐magmatic components such as serpentinized mantle. Excepting regions of extensive mantle exposure, most morphologic parameters that we examined are sensitive to estimated magma supply but not necessarily to spreading rate alone. We summarize our results in schematic models that relate morphologic variations to changes in magma supply and mantle serpentinization throughout the global MOR system. Finally, we note that combined qualitative and quantitative results of our study may be useful for developing automated morphologic classification schemes.
Reasons for Low Fraction of Arctic Stratospheric Cloud in 2014/2015 Winter
Authors: Zhao Zhixin , Wang Wencai , Wang Yuwei , Sheng Lifang , Zhou Yang , Teng Shiwen 
Published: November 2023

AbstractPolar stratospheric clouds (PSCs) play a key role in Arctic amplification and stratospheric ozone destruction in polar regions. In this paper, we used the CALIPSO data to analyze the spatiotemporal distribution of Arctic PSCs from 2006 to 2021. We found that Arctic PSCs mainly appear in December, peak in late December and early January, disappearing in late February and early March. PSCs can extend from heights near the tropopause to over 25 km. However, there is the lowest fraction of PSCs in the 2014/2015 winter. This study found that the temperature in the 2014/2015 winter was warmer than the 15‐year average temperature, with the lowest temperature slightly below the PSCs formation temperature of about 5 K. The formation of the Ural blocking high accompanied by the poleward propagation of the planetary wave caused a sudden stratospheric warming (SSW) event on 3 January 2015, during which the warm air entered the polar vortex and divided it into two lobes. Additionally, a reduction in SO2 column mass density before the SSW event resulted PSCs occurring with a frequency of only 0.148 and dissipating rapidly in December. Moreover, the concentration of H2O and HNO3 in the gravitational settling process of PSCs decreased by 20–50%, the reduction of condensation nuclei made PSCs with the highest frequency of 0.074 in February appear briefly and then disappear. The chemical and dynamic analysis of PSCs formation is needed to further understand the spatiotemporal distribution of Arctic PSCs and to better predict future Arctic amplification and ozone destruction.
The impact of genetic risk for schizophrenia on eating disorder clinical presentations
Authors: Zhang Ruyue , Kuja-Halkola Ralf , Borg Stina , Leppä Virpi , Thornton Laura M. , Birgegård Andreas , Bulik Cynthia M. , Bergen Sarah E. 
Published: November 2023

AbstractA growing body of literature recognizes associations between eating disorders (EDs) and schizophrenia and suggests that familial liability to schizophrenia in individuals with anorexia nervosa (AN) reveals distinct patterns of clinical outcomes. To further investigate the influence of schizophrenia genetic liability among individuals with EDs, we evaluated the associations between schizophrenia polygenic risk scores (PRS) and clinical presentations of individuals with EDs including their overall health condition and ED-related symptoms. Using data from two previous studies of the genetics of EDs comprising 3,573 Anorexia Nervosa Genetics Initiative (ANGI) cases and 696 Binge Eating Genetics Initiative (BEGIN) cases born after 1973 and linked to the Swedish National Patient Register, we examined the association of schizophrenia PRS on ED clinical features, psychiatric comorbidities, and somatic and mental health burden. Among ANGI cases, higher schizophrenia PRS was statistically significantly associated with higher risk of major depressive disorder (MDD) measured by hazard ratio (HR) with 95% confidence interval (CI) (HR [95% CI]: 1.07 [1.02, 1.13]) and substance abuse disorder (SUD) (HR [95% CI]: 1.14 [1.03, 1.25]) after applying multiple testing correction. Additionally, higher schizophrenia PRS was associated with decreased clinical impairment assessment scores (−0.56, 95% CI: [−1.04, −0.08]) at the conventional significance level (p < 0.05). Further, in BEGIN cases, higher schizophrenia PRS was statistically significantly associated with earlier age at first ED symptom (−0.35 year, 95% CI: [−0.64, −0.06]), higher ED symptom scores (0.16, 95% CI: [0.04, 0.29]), higher risk of MDD (HR [95% CI]: 1.18 [1.04, 1.34]) and SUD (HR [95% CI]: 1.36 [1.07, 1.73]). Similar, but attenuated, patterns held in the subgroup of exclusively AN vs other eating disorder (OED) cases. These results suggest a similar pattern of influence of schizophrenia PRS for AN and OED cases in terms of psychiatric comorbidities, but a different pattern in terms of ED-related clinical features. The disparity of the effect of schizophrenia PRS on AN vs OED merits further investigation.
Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
Authors: Elwood Peter , Morgan Gareth , Watkins John , Protty Majd , Mason Malcolm , Adams Richard , Dolwani Sunil , Pickering Janet , Delon Christine , Longley Marcus 
Published: November 2023

AbstractAspirin as a possible treatment of cancer has been of increasing interest for over 50 years, but the balance of the risks and benefits remains a point of contention. We summarise the valid published evidence ‘for’ and ‘against’ the use of aspirin as a cancer treatment and we present what we believe are relevant ethical implications. Reasons for aspirin include the benefits of aspirin taken by patients with cancer upon relevant biological cancer mechanisms. These explain the observed reductions in metastatic cancer and vascular complications in cancer patients. Meta-analyses of 118 observational studies of mortality in cancer patients give evidence consistent with reductions of about 20% in mortality associated with aspirin use. Reasons against aspirin use include increased risk of a gastrointestinal bleed though there appears to be no valid evidence that aspirin is responsible for fatal gastrointestinal bleeding. Few trials have been reported and there are inconsistencies in the results. In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse
Authors: Li Jiabing , Xiao Shujun , Shi Fangfang , Song Huaxin , Wu Jiaqi , Zheng Derun , Chen Xueqin , Tan Kai , Lu Min 
Published: November 2023

AbstractLi-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. It is a severe cancer predisposition syndrome with a poor prognosis, partly due to the frequent development of subsequent primary tumors following DNA-damaging therapies. Here we explored, for the first time, the effectiveness of mutant p53 rescue compound in treating LFS-mimicking mice harboring a deleterious p53 mutation. Among the ten p53 hotspot mutations in IARC LFS cohorts, R282W is one of the mutations predicting the poorest survival prognosis and the earliest tumor onset. Among the six clinical-stage mutant p53 rescue compounds, arsenic trioxide (ATO) effectively restored transactivation activity to p53-R282W. We thus constructed a heterozygous Trp53 R279W (corresponding to human R282W) mouse model for the ATO treatment study. The p53R279W/+ (W/+) mice exhibited tumor onset and overall survival well mimicking the ones of human LFS. Further, 35 mg/L ATO addition in drink water significantly extended the median survival of W/+ mice (from 460 to 596 days, hazard ratio = 0.4003, P = 0.0008). In the isolated tumors from ATO-treated W/+ mice, the representative p53 targets including Cdkn1a, Mdm2, and Tigar were significantly upregulated, accompanying with a decreased level of the proliferation marker Ki67 and increased level of apoptosis marker TUNEL. Together, the non-genotoxic treatment of p53 rescue compound ATO holds promise as an alternative for LFS therapeutic.
A 39 kb structural variant causing Lynch Syndrome detected by optical genome mapping and nanopore sequencing
Authors: Bjørnstad Pål Marius , Aaløkken Ragnhild , Åsheim June , Sundaram Arvind Y. M. , Felde Caroline N. , Østby G. Henriette , Dalland Marianne , Sjursen Wenche , Carrizosa Christian , Vigeland Magnus D. , Sorte Hanne S. , Sheng Ying , Ariansen Sarah L. , Grindedal Eli Marie , Gilfillan Gregor D. 
Published: November 2023

AbstractLynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline variants in one of the four mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. It is characterized by a significantly increased risk of multiple cancer types, particularly colorectal and endometrial cancer, with autosomal dominant inheritance. Access to precise and sensitive methods for genetic testing is important, as early detection and prevention of cancer is possible when the variant is known. We present here two unrelated Norwegian families with family histories strongly suggestive of LS, where immunohistochemical and microsatellite instability analyses indicated presence of a pathogenic variant in MSH2, but targeted exon sequencing and multiplex ligation-dependent probe amplification (MLPA) were negative. Using Bionano optical genome mapping, we detected a 39 kb insertion in the MSH2 gene. Precise mapping of the insertion breakpoints and inserted sequence was performed by low-coverage whole-genome sequencing with an Oxford Nanopore MinION. The same variant was present in both families, and later found in other families from the same region of Norway, indicative of a founder event. To our knowledge, this is the first diagnosis of LS caused by a structural variant using these technologies. We suggest that structural variant detection be performed when LS is suspected but not confirmed with first-tier standard genetic testing.
Charge-loop current order and Z3 nematicity mediated by bond order fluctuations in kagome metals
Authors: Tazai Rina , Yamakawa Youichi , Kontani Hiroshi 
Published: November 2023

AbstractRecent experiments on geometrically frustrated kagome metal AV3Sb5 (A = K, Rb, Cs) have revealed the emergence of the charge loop current (cLC) order near the bond order (BO) phase. However, the origin of the cLC and its interplay with other phases have been uncovered. Here, we propose a novel mechanism of the cLC state, by focusing on the BO phase common in kagome metals. The BO fluctuations in kagome metals, which emerges due to the Coulomb interaction and the electron-phonon coupling, mediate the odd-parity particle-hole condensation that gives rise to the topological current order. Furthermore, the predicted cLC+BO phase gives rise to the Z3-nematic state in addition to the giant anomalous Hall effect. The present theory predicts the close relationship between the cLC, the BO, and the nematicity, which is significant to understand the cascade of quantum electron states in kagome metals. The present scenario provides a natural understanding.