bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Physical Properties of Arabica and Robusta Coffee Beans from Temanggung and Lampung
Authors: Kurniasari I. , Yohanes H. , Hartono L. K. , Komariyah K. , Widodo W. E. , Atmaji G. , Astin E. P. , Madjid A. , Alfa M. N. 
Published: October 2023

Abstract
The development of processes and handling techniques, packing, and transportation of coffee beans all benefit from knowledge of the physical attributes of coffee beans. This research was done to describe the physical characteristics of green and roasted Temanggung and Lampung coffee beans. The findings revealed that Robusta roasted beans from Lampung with a moisture content of 1.70% had the highest values of bean dimensions, geometric mean diameter, arithmetic mean diameter, equivalent mean diameter, frontal surface area, surface area, and volume. Arabica green beans from Lampung and Temanggung had the highest shape index and density values, whereas Arabica roasted beans from Lampung had the highest aspect ratio and sphericity values. Arabica green beans from Temanggung and Arabica roasted beans from Lampung had moisture contents of 6.46% and 2.69%, respectively. Meanwhile, Robusta green beans from Lampung had the greatest scores for mass and porosity. To offer somewhat full information on the design factors involved in the roasting profile of a coffee roaster, other engineering properties should be investigated in future studies.
Effect of Liquid to Solid Ratio in Rumen Content on Feedstuffs’ in Vitro Fermentability and Digestibility
Authors: Evvyernie D , Nugraha R B , Despal  , Zahera R 
Published: October 2023

Abstract
The amount of fibrous feed consumed by tropical cattle has an impact on the rumen’s liquid-to-solid ratio and feed passage rate. Feed fermentability and digestibility are influenced by ratio. Several in vitro procedures use varying liquid-to-solid ratios, which may or may not be applicable to the local situation. The purpose of this study is to compare the local cow rumen conditions with the liquid-to-solid ratio employed in the in vitro investigation. There were two experiments done for the study. First, the liquid-to-solid ratios in various in vitro experiments (Tilley and Terry = T1, Theodorou = T2, and Sutardi = T3) were compared to the circumstances in the rumen of local cattle (T0). Second, it was determined whether the various liquid-to-solid ratios used in various in vitro techniques were similar in terms of the feedstuffs’ fermentability (pH, NH3, VFA), digestibility (DMD and OMD), and fermentability (DMD and OMD) (F1 = Napier grass, F2 = maize, and F3 = soybean oil meal). The first experiment was fully utilized, and a 3 x 3 block factorial randomized design was used (second experiment). The liquid-to-solid ratio of T3 (1: 40) was discovered to be more comparable to the rumen state of nearby cattle (1:46). Different in vitro techniques had no discernible impact on pH, VFA, DMD, or OMD, but T3 produced more NH3 than T1 or T2 did. With F3 higher than F2 or F1, the major effects of fermentability and digestibility were discovered inside the feed. It is found that every feed studied produced higher NH3 concentrations thanks to the Sutardi method’s liquid-to-solid ratio, which is more akin to the rumen of local cattle. As a result, it is advised to evaluate feedstuff fermentability and digestibility for local cattle using the Sutardi method.
The Effect of Long Time of Storage on Physical Quality, Nutrient Content, and In Vitro Digestibility of Cattle Complete Feed
Authors: Prasetyo Amrih , Prabowo Agung , Hayati Rini Nur , Kurnianto Heri 
Published: October 2023

Abstract
This research aimed to determine the effect of a long time of storage on physical quality, nutrient content, and in vitro digestibility of cattle complete feed. The research was carried out in Sidomulyo Village, Gunem District, Rembang Regency from March to October 2019. 15 drums of cattle complete feed (@ 25 kg) were used as materials. It was made from rice bran 4.10%; Penisitum purpureum (Odot grass) 60.60%; rice straw 12.70%; gliricidia 8.30%; corn stover 10.80%; molasses 1.60%; minerals 1.60%; table salt 0.20%; and starter 0.30%. This research used one treatment factor, namely the length of time of storage of cattle complete feed. These consisted of five treatments, namely: long time of storage of 0.0; 1.5; 3.0; 4.5; and 6.0 months. Each treatment was repeated three times. The cattle complete feed with all the long time of storage preferred by the cattle. The cattle complete feed could be stored in good quality for 3 months. The storage over 3 months caused the quality of the cattle’s complete feed to decrease. The crude protein content decreased with increasing storage time. The long time of storage did not affect the in vitro digestibility of dry matter and organic matter. the impact of feeding techniques was investigated. Applying the whole feed diet during the growing phase and up until the early fattening phase, and then concluding with concentrate and forage, did not significantly affect 1) SCF, 2) TMRGSCF
Novel 3D-printing bilayer GelMA-based hydrogel containing BP, β-TCP and exosomes for cartilage–bone integrated repair
Authors: Sun Ting , Feng Zhiqiang , He Wenpeng , Li Chufeng , Han Songning , Li Zejian , Guo Rui 
Published: October 2023

Abstract
The integrated repair of cartilage and bone involves the migration and differentiation of cells, which has always been a difficult problem to be solved. We utilize the natural biomaterial gelatin to construct gelatin methacryloyl (GelMA), a hydrogel scaffold with high cell affinity. GelMA is mixed with different components to print a bi-layer porous hydrogel scaffold with different modulus and composition in upper and lower layers through three-dimensional (3D) printing technology. The upper scaffold adds black phosphorus (BP) and human umbilical cord mesenchymal stem cells (hUMSCs) exosomes (exos) in GelMA, which has a relatively lower elastic modulus and is conducive to the differentiation of BMSCs into cartilage. In the lower scaffold, in addition to BP and hUMSCs exos, β-tricalcium phosphate (β-TCP), which has osteoconductive and osteoinductive effects, is added to GelMA. The addition of β-TCP significantly enhances the elastic modulus of the hydrogel scaffold, which is conducive to the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs). In vitro experiments have confirmed that the bi-layer scaffolds can promote osteogenesis and chondrogenic differentiation respectively. And in the rabbit cartilage–bone injury model, MRI and micro-CT results show that the 3D printed bi-layer GelMA composite scaffold has a repair effect close to normal tissue.
Different Sources of Fiber Intake and Risk of 17 Specific Cancers and All Cancers Combined: Prospective Study of 364,856 Participants in the UK Biobank
Authors: Parra-Soto Solange , Araya Carolina , Knight Katrina , Livingstone Katherine M , Malcomson Fiona C , Sharp Linda , Mathers John C , Ho Frederick K , Celis-Morales Carlos , Pell Jill P 
Published: October 2023

Abstract
Inverse associations between dietary fiber (DF) and colorectal cancer risk are well-established. However, evidence is limited in relation to other cancer sites. This study, of 364,856 participants from the UK Biobank, aimed to evaluate the associations between total and source-specific partial DF and risk of 17 specific cancers and all cancers combined. Partial DF was derived from baseline touchscreen questionnaire data on cereal, bread, fruit, and vegetable intake. The outcomes were incident cancer at 17 sites and all cancers combined. Cox proportional hazards models were applied. Over a median 8.8-year follow-up period, 30,725 people were diagnosed with cancer. After adjusting for sociodemographic and lifestyle factors, those in the highest quintile of partial DF compared with the lowest quintile (&lt;9.6 vs ≥19.1 g/day) had 10% lower risk of cancer overall, with the greatest risk reductions observed for cervical (hazard ratio (HR) = 0.33, 95% confidence interval (CI): 0.14; 0.82), esophageal (HR = 0.66, 95% CI: 0.52; 0.84), lung (HR = 0.67, 95% CI: 0.59; 0.76), bladder (HR = 0.72, 95% CI: 0.56; 0.91), and kidney (HR = 0.75, 95% CI: 0.61; 0.92) cancers. Associations between DF and lung cancer were observed only in current and former smokers. Higher DF intake, in particular cereal fiber and fruit and vegetable fiber, was associated with a lower risk of overall and multiple site-specific cancers.
Hearts and Minds: Emotion Recognition and Mentalizing in Parkinson's Disease and Progressive Supranuclear Palsy
Authors: Martins Marina I , Cardoso Francisco E C , Caramelli Paulo , Mariano Luciano I , Rocha Natalia P , Jaeger Antônio , Teixeira Antônio L , Tumas Vítor , Camargos Sarah T , de Souza Leonardo C 
Published: October 2023

Abstract

Objective
There are scarce data comparing Parkinson’s disease (PD) and Progressive Supranuclear Palsy (PSP) in social cognition (SC). We aimed to compare patients with PSP and PD in SC.

Methods
We included three groups: PD (n = 18), PSP (n = 20) and controls (n = 23). Participants underwent neuropsychological exams, including the mini-version of the Social and Emotional Assessment, which is composed of the facial emotion recognition test (FERT) and the modified faux-pas (mFP) test, which assesses Theory of Mind (ToM).

Results
Patients with PD scored lower than controls in the FERT, but not in the mFP test. Patients with PSP performed worse than controls in both the mFP and FERT. PD and PSP groups did not differ in the FERT, but PSP performed worse than PD in the mFP test. The mFP test distinguished PSP from PD with 89% accuracy.

Conclusion
The assessment of ToM may contribute to the differentiation between PD and PSP.
Betaine ameliorates heat stress-induced apoptosis by affecting oxidative and endoplasmic reticulum stress in mouse Leydig cells
Authors: Xiong Yongjie , Li Bing , Wang Kang , Li Jing , He Shaojun 
Published: October 2023

Abstract
In order to explore the potential protective role of betaine in heat stress (HS)-elicited apoptosis in mouse Leydig cells (mLCs). Betaine at 16 mm exerted a greater inhibitory effect on HS-induced viability attenuation of cells, which also significantly suppressed the heat shock protein 70 level in HS-treated cells. Furthermore, betaine ameliorated certain negative effects, including increased cell apoptotic ratio, enhancement of apoptosis-related modulator caspase-3 activity, reduced activity levels of such antioxidant enzymes as SOD, CAT, GSH-Px, and MDA upregulation, and inhibited the protein levels of critical endoplasmic reticulum (ER) stress indices like CHOP and GRP78 in mLCs exposed to HS. Besides, treatment of cells with betaine significantly restored diminished testosterone production in response to HS. Correspondingly, betaine effectively rescued the reduced serum testosterone concentration in vivo. In summary, betaine ameliorated HS-induced apoptosis by affecting oxidative and ER stress, thereby providing benefits for the treatment of hyperthermia-related impairment in mLCs.
SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis
Authors: Rajanala Sai Harisha , Plym Anna , Vaselkiv Jane B , Ebot Ericka M , Matsoukas Konstantina , Lin Zhike , Chakraborty Goutam , Markt Sarah C , Penney Kathryn L , Lee Gwo-Shu M , Mucci Lorelei A , Kantoff Philip W , Stopsack Konrad H 
Published: October 2023

Abstract
Solute carrier organic anion (SLCO) transporters (OATP transporters) are involved in cellular uptake of drugs and hormones. Germline variants in SLCO1B3 and SLCO2B1 have been implicated in prostate cancer progression and therapy response, including to androgen deprivation and statin medications, but results have appeared heterogeneous. We conducted a cohort study of five single-nucleotide polymorphisms (SNPs) in SLCO1B3 and SLCO2B1 with prior evidence among 3208 men with prostate cancer who participated in the Health Professionals Follow-up Study or the Physicians’ Health Study, following participants prospectively after diagnosis over 32 years (median, 14 years) for development of metastases and cancer-specific death (lethal disease, 382 events). Results were suggestive of, but not conclusive for, associations between some SNPs and lethal disease and differences by androgen deprivation and statin use. All candidate SNPs were associated with SLCO mRNA expression in tumor-adjacent prostate tissue. We also conducted a systematic review and harmonized estimates for a dose-response meta-analysis of all available data, including 9 further studies, for a total of 5598 patients and 1473 clinical events. The A allele of the exonic SNP rs12422149 (14% prevalence), which leads to lower cellular testosterone precursor uptake via SLCO2B1, was associated with lower rates of prostate cancer progression (hazard ratio per A allele, 0.80; 95% confidence interval, 0.69–0.93), with little heterogeneity between studies (I2, 0.27). Collectively, the totality of evidence suggests a strong association between inherited genetic variation in SLCO2B1 and prostate cancer prognosis, with potential clinical use in risk stratification related to androgen deprivation therapy.
Getting left behind? The localised consequences of exclusion from the credit market for UK SMEs
Authors: Cowling Marc , Brown Ross , Liu Weixi , Rocha Augusto 
Published: October 2023

Abstract
Recent research has identified a key subset of the business population that comprises firms who had sought external finance but subsequently withdrew from the credit market completely despite still requiring finance. Utilising the UK’s Longitudinal Small Business Survey between 2015 and 2020, we identify the consequences in terms of lost jobs and sales of these small- and medium-sized enterprises (SMEs) dropping out of the credit market for finance. We conduct our analysis at the regional and sub-regional level and found that around 230,000 SMEs have dropped out of the UK credit market and that in many localities this has reduced job creation and sales income growth. We conclude that this exclusionary borrowing behaviour will add further to existing regional and sub-regional economic inequalities in the UK, making the ‘levelling up’ agenda a very elusive policy objective.
Effects of Systemic Peroxisome Proliferator-Activated Receptor Gamma Inhibition on Bone and Immune Cells in Aged Female Mice
Authors: Shi Xingming , Ding Kehong , Rosario Raysa , Ajith Ashwin , Su Yun , Shaw Sean , McGee-Lawrence Meghan , Lu Xin-Yun , Horuzsko Anatolij , Isales Carlos M 
Published: October 2023

Abstract
This study investigates the effects of peroxisome proliferator-activated receptor gamma (PPARγ) inhibition on bone and immune cell profiles in aged female mice, as well as in vitro stromal stem cell osteogenic differentiation and inflammation gene expression. The hypothesis was that inhibition of PPARγ would increase bone mass and alter immune and other cellular functions. Our results showed that treatment with PPARγ antagonist GW9662 for 6 weeks reduced bone volume and trabecular number and increased trabecular spacing. However, inhibition of PPARγ had no significant effect on marrow and spleen immune cell composition in aged female mice. In vitro experiments indicated that GW9662 treatment increased the expression of osteogenic genes but did not affect adipogenic genes. Additionally, GW9662 treatment decreased the expression of several inflammation-related genes. Overall, these findings suggest that PPARγ inhibition may have adverse effects on bone in aged female mice.
Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas
Authors: Kelly Emily A , Echeverri Alegre Jose I , Promer Katherine , Hayon Jesica , Iordanov Roumen , Rangwalla Khuzaima , Zhang Jerry J , Fang Zian , Huang Cindy , Bittencourt Cassiana E , Reed Sharon , Andrade Rosa M , Bern Caryn , Clark Eva H , Whitman Jeffrey D 
Published: October 2023

Abstract

Background
Chagas disease (CD) is a parasitic disease that affects ∼300 000 people living in the United States. CD leads to cardiac and/or gastrointestinal disease in up to 30% of untreated people. However, end-organ damage can be prevented with early diagnosis and antiparasitic therapy.

Methods
We reviewed electronic health records of patients who underwent testing for CD at four hospital systems in California and Texas between 2016 and 2020. Descriptive analyses were performed as a needs assessment for improving CD diagnosis.

Results
In total, 470 patients were tested for CD. Cardiac indications made up more than half (60%) of all testing, and the most frequently cited cardiac condition was heart failure. Fewer than 1% of tests were ordered by obstetric and gynecologic services. Fewer than half (47%) of patients had confirmatory testing performed at the Centers for Disease Control and Prevention.

Discussion
Four major hospitals systems in California and Texas demonstrated low overall rates of CD diagnostic testing, testing primarily among older patients with end-organ damage, and incomplete confirmatory testing. This suggests missed opportunities to diagnose CD in at-risk individuals early in the course of infection when antiparasitic treatment can reduce the risk of disease progression and prevent vertical transmission.
Effects of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans on Modeling Subgingival Microbiome and Impairment of Oral Epithelial Barrier
Authors: Li Zihan , Huang Qiuxia , Wang Zhuoran , Huang Lijia , Gu Lisha 
Published: October 2023

Abstract
Periodontitis is an exemplar of dysbiosis associated with the coordinated action of multiple members within the microbial consortium. The polymicrobial synergy and dysbiosis hypothesis proposes a dynamic host-microbiome balance, with certain modulators capable of disrupting eubiosis and driving shifts towards dysbiosis within the community. However, these factors remain to be explored. We established a Porphyromonas gingivalis- or Aggregatibacter actinomycetemcomitans-modified subgingival microbiome model and 16S rRNA sequencing revealed that P. gingivalis and A. actinomycetemcomitans altered the microbiome structure and composition indicated by α and β diversity metrics. P. gingivalis increased the subgingival dysbiosis index (SDI), while A. actinomycetemcomitans resulted in a lower SDI. Furthermore, P. gingivalis-stimulated microbiomes compromised epithelium function and reduced expression of tight junction proteins, whereas A. actinomycetemcomitans yielded mild effects. In conclusion, by inoculating P. gingivalis, we created dysbiotic microcosm biofilms in vitro resembling periodontitis-related subgingival microbiota, exhibiting enhanced dysbiosis and impaired epithelium integrity.
Comparison of prophylactic antibiotics for endonasal transsphenoidal surgery using a national inpatient database in Japan
Authors: Hattori Yujiro , Tahara Shigeyuki , Aso Shotaro , Makito Kanako , Matsui Hiroki , Fushimi Kiyohide , Yasunaga Hideo , Morita Akio 
Published: October 2023

Abstract

Background
The choice of prophylactic antibiotics for use in endonasal transsphenoidal surgery (ETSS) lacks universal standards. This study aimed to investigate the effectiveness of cefazolin, ampicillin and third-generation cephalosporins for preventing postoperative meningitis and secondary outcomes (in-hospital death and the combination of pneumonia and urinary tract infection) in patients who have undergone ETSS.

Methods
The study used data from the Diagnosis Procedure Combination database in Japan. Data from 10 688 patients who underwent ETSS between April 2016 and March 2021 were included. Matching weight analysis based on propensity scores was conducted to compare the outcomes of patients receiving cefazolin, ampicillin or third-generation cephalosporins as prophylactic antibiotics.

Results
Of the 10 688 patients, 9013, 102 and 1573 received cefazolin, ampicillin and third-generation cephalosporins, respectively. The incidence of postoperative meningitis did not significantly differ between the cefazolin group and the ampicillin group (OR, 1.02; 95% CI, 0.14–7.43) or third-generation cephalosporins group (OR, 0.81; 95% CI, 0.10–6.44). Similarly, in-hospital death and the composite incidence of pneumonia and urinary tract infection did not differ between the cefazolin group and the ampicillin or third-generation cephalosporins group.

Conclusions
Cefazolin, ampicillin and third-generation cephalosporins as perioperative prophylactic antibiotics for ETSS do not differ significantly in terms of preventing meningitis.
‘Nobody Is Proud of Soft Dollars’: the Impact of MiFID II on US Financial Markets
Authors: Jackson Howell E , Zhang Jeffery Y 
Published: October 2023

Abstract
Scholars and policy makers have long debated whether securities firms should be allowed to bundle the cost of execution services with the cost of research. Investor advocates condemn the practice whereas industry representatives defend it. In 2018, as part of the Markets in Financial Instruments Directive II (MiFID II) legislative regime, the EU forced the unbundling of commission charges, diverging from US legal standards which still allow ‘soft dollar’ payments for research. The EU’s unbundling regime has challenged global financial services firms, which must now comply with conflicting rules across national boundaries. For more than five years, the US Securities and Exchange Commission provided temporary no-action relief to facilitate compliance with MiFID II, but that relief expired in July 2023, presenting an opportunity to reconsider the impact of MiFID II’s unbundling regime and its implications for US regulators and investors. While this article takes a critical view of soft dollar practices, the story of MiFID II presents contested issues of policy analysis as the agency costs inherent in bundled commissions could be offset by the public benefits of additional research. Unbundling also offers a noteworthy example of an innovation in capital markets regulation flowing from Europe to the United States rather than the other way around.
Algebraic structures formalizing the logic with unsharp implication and negation
Authors: Chajda Ivan , Länger Helmut 
Published: October 2023

Abstract
It is well-known that intuitionistic logics can be formalized by means of Heyting algebras, i.e. relatively pseudocomplemented semilattices. Within such algebras the logical connectives implication and conjunction are formalized as the relative pseudocomplement and the semilattice operation meet, respectively. If the Heyting algebra has a bottom element $0$, then the relative pseudocomplement with respect to $0$ is called the pseudocomplement and it is considered as the connective negation in this logic. Our idea is to consider an arbitrary meet-semilattice with $0$ satisfying only the Ascending Chain Condition (these assumptions are trivially satisfied in finite meet-semilattices) and introduce the operators formalizing the connectives negation $x^{0}$ and implication $x\rightarrow y$ as the set of all maximal elements $z$ satisfying $x\wedge z=0$ and as the set of all maximal elements $z$ satisfying $x\wedge z\leq y$, respectively. Such a negation and implication is ‘unsharp’ since it assigns to one entry $x$ or to two entries $x$ and $y$ belonging to the semilattice, respectively, a subset instead of an element of the semilattice. Surprisingly, this kind of negation and implication still shares a number of properties of these connectives in intuitionistic logic, in particular the derivation rule Modus Ponens. Moreover, unsharp negation and unsharp implication can be characterized by means of five, respectively seven simple axioms. We present several examples. The concepts of a deductive system and of a filter are introduced as well as the congruence determined by such a filter. We finally describe certain relationships between these concepts.