bluuebunny/crossref_metadata_2025_split huggingface dataset:
Van ruilen komt huilen? Het beroep in zaak T-312/20 tegen de RWE/E.ON asset swap
Authors: Brouwer F.J.H. 
Published: November 2023

Van ruilen komt huilen? Het beroep in zaak T-312/20 tegen de RWE/E.ON asset swap
Het Gerecht oordeelt in dit arrest over een complexe asset swap die is overeengekomen door RWE en E.ON op de Duitse energiemarkt. In het arrest wordt bevestigd dat derde partijen actief bij de administratieve procedure moeten zijn betrokken om ontvankelijk te zijn in hun beroep bij het Gerecht. Het Gerecht bevestigt voor het eerst dat een activaruil niet beoordeeld kan worden als één enkele concentratie, maar leidt tot verschillende te onderzoeken transacties. De Commissie moet in de beoordeling daarvan wel rekening houden met de gevolgen die de concentraties onderling tot stand brengen op de relevante markten, voor zover die gevolgen voorzienbaar zijn. De prioriteitsregel die de Commissie daarvoor heeft ontwikkeld, kan de reikwijdte van dat onderzoek in dit geval niet beperken. Afsluitend laten de arresten van het Gerecht zien dat er beperkt ruimte is voor een beoordeling van kartelaantijgingen binnen het concentratietoezicht.Gerecht 17 mei 2023, T-312/20, ECLI:EU:T:2023:252 (E.ON/RWE asset swap)
A dupla listagem e o custo de capital: uma análise das empresas brasileiras emitentes de depositary receipts em tempos de crise financeira internacional
Authors: Queiroz Lísia de Melo , Pimenta Junior Tabajara 
Published: November 2023

A dupla listagem é uma estratégia que supostamente pode minimizar os efeitos de uma crise financeira internacional sobre o risco e o retorno das ações da empresa. Este estudo buscou analisar se esta suposição é válida para companhias brasileiras, no contexto da crise de 2008. Os efeitos da crise sobre retorno e risco das ações com dupla listagem foram também comparados com os das ações de empresas sem dupla listagem. As análises foram feitas, com base em testes estatísticos de hipóteses, sobre séries históricas de retorno referentes ao período de dez anos no entorno da crise financeira internacional de 2008. Os resultados mostraram que os impactos sobre ambos os tipos de empresas foram semelhantes. Estes resultados são compatíveis com os de Cotter (2004), Bin, Blenman e Chen (2004), e Huang e Stoll (2001), mas contradizem Chandar, Patro e Yezegel (2009). A principal conclusão do estudo é que a crise afetou de forma semelhante as ações de todas as empresas e, portanto, a dupla listagem não minimizou seus efeitos.
Residual Effect of Biochar and Legumes on Soil Fertility, Yield and Yield Components of Wheat
Authors: Bangash Saqib Hussain , Ullah Farman , Azam Sajjad , Hussain Sharafat , Hussain Tasawar , Fatima Iza , Sherbano Bibi 
Published: November 2023

Biochar and the use of legumes in cropping systems are considered sustainable approaches to boost crop yield and preserve soil fertility. In the current study, the effects of leftover biochar and previously planted legumes on wheat yield and soil N status were examined at various nitrogen (N) levels. The experiment included testing two levels of previously applied biochar (0 and 50 tons ha-1), three legumes under four levels of N (0, 60, 90, and 120 kg ha-1), cowpea (Vigna unguiculata) for fodder, Sesbenia (Sesbenia grandaflora) for green manuring, and mung bean (Vigna radiata) for grain. Results showed that biochar application enhanced wheat tiller m-2, spikes m-2, grains per spike, thousand grain weight, grain yield, biological yield, and soil total N status by 3%, 6.5%, 3.7%, 1.8%, 7.8%, 9.5%, and 11%, respectively. Moreover, applying nitrogen at a rate of 90 kg ha-1 increased the amount of wheat spike m-2 by 20%, grain spike-1 by 10%, grain yield by 70%, biological yield by 48%, harvest index by 27%, and the N content of the grain, straw, and soil by 13%, 14%, and 36% respectively. Meanwhile, 1000 grain weight resulted higher by 6.17%. Legumes that had been previously seeded outperformed fallow and increased spikes m-2, grain yield, biological yield, grain N content, and soil total N content by 8.2%, 11%, 6.78%, 25%, and 42%, respectively. It is determined that applying biochar to the summer gap left by legumes can increase soil fertility and wheat output.
Suivis acoustiques de biodiversité : perspectives et défis en milieu continental terrestre
Authors: LE BORGNE Hélène , BOUGET Christophe 
Published: November 2023

Les animaux produisent des sons pendant leurs activités ou pour assurer diverses fonctions biologiques comme la défense de territoires, l’attraction de partenaires, la dissuasion des prédateurs. En enregistrant ces données acoustiques, les scientifiques obtiennent des informations essentielles sur la présence des espèces. Les nouvelles technologies d’identification des espèces sont plus abordables, efficaces et polyvalentes que les méthodes classiques et peuvent ainsi répondre au besoin urgent de documenter la biodiversité dans le contexte actuel de crise. Les enregistreurs acoustiques automatisés sont de plus en plus utilisés dans les suivis de biodiversité pour faire face aux limites des méthodes plus traditionnelles et à l’émergence de considérations déontologiques préconisant le développement de pièges non destructifs (i.e. non létaux). Nous présentons ici les outils d’acquisition des données en milieu continental terrestre, les méthodes de gestion et d’analyse des données pour la classification automatique des espèces et l’étude des paysages sonores, et les avantages et les limites de l’utilisation de ces outils dans un objectif de suivi de la biodiversité en milieu terrestre.
Retrospective Assessment of an Adalimumab Model–Informed Precision Dosing Support Tool for Use in Pediatric Inflammatory Bowel Disease
Authors: Avalos Yesenia , Gothard M. David , Moses Jonathan , Finkler Michael 
Published: November 2023

OBJECTIVES
Therapeutic drug monitoring in pediatric inflammatory bowel disease (IBD) has been used to achieve and maintain remission. Few guidelines exist to aid clinicians in the adjustment of anti–tumor necrosis factor therapies. The objective was to assess the agreement between real-world postinduction and posteriori analysis of retrospective data, using 2 novel pharmacokinetic (PK) models for adalimumab.

METHODS
A retrospective chart review was conducted in pediatric IBD patients treated with adalimumab. A Bayesian clinical decision support tool (InsightRX) was used. Postinduction serum concentration measurements of adalimumab were performed by drug-tolerant, homogenous shift mobility assay. Predicted serum adalimumab concentrations from both models were compared to the actual serum concentrations through a Bland-Altman analysis. Paired sample t test was used for equivalence.

RESULTS
A total of 47 patients were included. Forty-one patients (87%) had Crohn disease, and 30 (64%) were male. Most were induced with 160 mg of adalimumab and maintained on 40 mg biweekly. No significant difference resulted between the de Klaver average prediction and mean population concentration (p = 0.294). Significant difference was observed between Ternant and mean population serum adalimumab concentration (p &lt; 0.001). The Bland-Altman plot for the de Klaver method showed no proportional bias. Additionally, 49% of patients required a dose adjustment during maintenance therapy.

CONCLUSIONS
The de Klaver model was able to provide less bias than the Ternant model and may aid in predicting serum adalimumab concentrations. Approximately half of the patients required dose adjustment during maintenance therapy to obtain a therapeutic drug concentration or achieve clinical remission.
The Use of Dexmedetomidine in Preterm Infants: A Single Academic Center Experience
Authors: Guillen-Hernandez Juan , Kyllonen Kay C. , Tumin Dmitry , Rodriguez Ricardo J. 
Published: November 2023

OBJECTIVE
Preterm newborns (PTNBs) often require sedation and analgesia. Dexmedetomidine (DEX) is used to provide sedation in extremely PTNBs, even though information on such use is limited. The objective of this research is to describe the use of DEX in these patients in a single academic center.

METHODS
This is a retrospective study of PTNBs receiving DEX from January 1, 2010, through December 31, 2018, at the Cleveland Clinic Children’s Hospital, a tertiary academic center operating 2 Level III and 1 Level IV neonatal intensive care units (NICUs). Inclusion criteria were gestational age (GA) &lt;36 weeks and receipt of DEX for &gt;2 days. Adequacy of clinical response was based on achieving Neonatal Pain, Agitation and Sedation Scale (N-PASS) scores &lt;3. Hypotension, bradycardia, and respiratory depression were recorded as the incidence as adverse events.

RESULTS
A total of 105 patients were included. The birth weight median was 870 g (IQR, 615–1507); the GA median was 26 weeks (IQR, 24–31). The duration of DEX infusion averaged 7 days. The DEX dose averaged 0.4 mcg/kg (IQR, 0.3–0.45). Bradycardia was observed in 35 patients (57%) weighting &lt;1 kg and in 7 patients (18%) &gt;1 kg (p &lt; 0.01). There was no difference in the incidence of other adverse events between these groups. However, infants &lt;1 kg required more pharmacologic interventions to maintain N-PASS score &lt;3.

CONCLUSIONS
DEX was well tolerated overall and provided adequate sedation to PTNBs in this cohort. From this study, we recommend a starting dose of 0.2 to 0.4 mcg/kg/hr and titrating up hourly until adequate sedation is achieved.
Prevalence, perception and risk factors of canine obesity in Thailand
Authors:   , Thaotumpitak Varangkana 
Published: November 2023

The proportion of obese dogs is increasing worldwide. It has become a topic of interest as it can impair quality of dog’s life and reduce longevity. The objectives of this study were to determine prevalence and risk factors of canine obesity in Thailand, misperception of owner on body shape of dogs and relationship between canine obesity and laboratory parameters. A cross-sectional study was performed with dogs aged over 1 year regardless of breed, sex and health status from 6 regions of Thailand (n=2,401). Results showed that prevalence of canine obesity was 42.94%. Risk factors by multivariable analyses were age 3-8 years old (OR=1.98), neutering (OR=1.63), snacking once daily (OR=1.47), and having obese dogs in the same household (OR=2.37). A comparison of body shape evaluation by owners and veterinarian showed discrepancy of these two assessments (p<0.0001) with 18.5% of dog owners underestimated their dogs’ body shape. Risk factors of underestimation were age >8 years old (OR= 1.90) and neutering (OR= 1.26). Blood collection was done for hematology and blood chemistry profile evaluation in two groups of dogs; clinically healthy non-obese dogs (n=50) and obese dogs (n=50). Total cholesterol and triglyceride were higher in obese dogs compared with non-obese dogs (p<0.05).

In conclusion, this is the first report about prevalence of canine obesity in Thailand. The high prevalence of obesity was found in this study (42.94%). In addition, misperception of owner on evaluation of body conformation may lead to lack of concern and being an obstacle for weight control regimen. Some laboratory parameters may be used as a diagnostic tool to promote awareness of the owners. Canine obesity should be considered as a part of basic health program and client education is needed in order to have successful control of canine obesity.
Tick diversity and pathogen infection in Khao Chi-On non hunting area and banglamung wildlife breeding center, Chonburi province, Thailand
Authors:   , Wattanamethanont Juntra 
Published: November 2023

Ixodid ticks are important vectors in the transmission cycle of various tick-borne diseases in both humans and animals. Wildlife are considered important reservoirs of these diseases. This study aims to examine tick diversity, and tick-borne protozoal and bacterial infection in questing ticks in wildlife habitats by using PCR and DNA sequencing techniques. In 2015, questing ixodid ticks were collected from Khao Chi-On Non Hunting Area and Banglamung Wildlife Breeding Center, Chonburi province. All 12,184 ticks were identified using morphological characteristics and representative ticks were confirmed species by PCR that targeted tick mitochondrial 16S rRNA gene. Three tick species were identified including Haemaphysalis lagrangei (92.82%), H. wellingtoni (0.13%), and Rhipicephalus (Boophilus) microplus (7.05%). Totally, 419 tick samples (Individual adult and nymph, and pooled larvae) were examined by using PCR which amplified a fragment of 18S rRNA gene of Babesia and Theileria, and 16S rRNA gene of bacteria in family Anaplasmataceae. Out of 419 analyzed tick samples, four pathogens and one bacterial symbiont were detected, with the highest infection rate of Anaplasma spp. at 55.61% (233/419) with three genotype groups including Anaplasma closely related to A. bovis, A. platys, and unidentified Anaplasma. While Theileria spp. had lower infection rate at 4.30% (18/419) with three genotypes consisted of Theileria closely related to T. cervi, T. capreoli, and unidentified Theileria, and only one sequence (1/419; 0.24%) of Babesia spp., Ehrlichia spp. and Wolbachia spp. were detected. These findings provided the information of tick diversity in wildlife habitats, and the association with detected tick-borne protozoa and bacteria. It suggested the evidences that these tick species are possible vectors to transmit tick-borne diseases in forest of Thailand. Furthermore, these data would be useful for designing treatment, prevention, and control strategies of tick-borne diseases.
Parasite burden, distribution and immunopathology of Leishmania Martiniquensis - infected BALB/c mice in different routes and time points
Authors:   , Somboonpoonpol Nawaphat 
Published: November 2023

Leishmaniasis is an emerging zoonotic vector-borne disease in Thailand transmitted by the bite of a tiny female phlebotomine sandfly. Autochthonous L. martiniquensis infection in Thai patients has been continuously reported since 2014 in patients co-infected with HIV, immunocompetent patient with or without underlying diseases and children. The objective of this study was to investigate the parasite burden, distribution and immunopathology in L. martiniquensis-infected BALB/c mice. Sixteen mice were intraperitoneally, i.p., intravenously, i.v., and subcutaneously, s.c., infected with 5x106 promastigotes of L. martiniquensis each. On 7, 14, 28 and 112 days post infection, dpi, 4 inoculated mice were euthanized from each inoculation group. Blood, livers, spleens, bone marrows, salivary glands and kidneys were collected at each time points. To detect the distribution of parasite, PCR targeting Leishmania-specific ITS1 genes was performed. DNA amplicons were detected from all BALB/c livers inoculated via i.v. and almost all mice via i.p. in all time points. For spleen, Leishmania DNAs were present in all time points from both i.v. and i.p. routes. Giemsa-stained impression smear of liver and spleen was conducted to analyse parasite burden in Leishman-Donovan unit (LDU). Via i.v. route, the highest parasite burden in liver was found on 7 dpi, 101 LDU, whereas it was shown in the spleen on 112 dpi, 3.1 LDU. To evaluate cell-mediated immune responses in liver, indirect immunohistochemical staining using L. martiniquensis-infected human serum was performed. The number of mature granuloma on 7, 14 and 28 dpi from i.v. route was found significantly superior than the non-infected control and other routes (p < 0.05). Reduction of immature and mature granuloma with development of involuting granuloma on 112 dpi in livers revealed the ability of BALB/c cellular immunity to control L. martiniquensis infection. In conclusion, this study is the first to reveal that L. martiniquensis is a causative agent for visceral leishmaniasis in BALB/c mice by experimental inoculation via i.v. and i.p. routes based on the presence of amastigotes as well as genomic DNAs of L. martiniquensis in important target organs.
Comparative in vitro killing activities of Enrofloxacin alone and in combination with Doxycycline against E. coli isolated from dogs and cats
Authors:   , Kireewan Supapatt 
Published: November 2023

Enrofloxacin and doxycycline are two of the most frequently used antibacterial agents in the veterinary practice. Enrofloxacin exhibits bactericidal activity especially against Gram-negative bacteria, while doxycycline demonstrates only bacteriostatic effect and is the drug of choice for treating intracellular bacteria, Ehrlichia canis (E. canis) in particular. On the occasion of Gram-negative bacteria and E. canis co-infection, using enrofloxacin in combination with doxycycline is inevitable. Theoretically, the antagonism between bactericidal and bacteriostatic agents has been well established. However, the drug interaction between enrofloxacin and doxycycline has not been yet identified especially against a common pathogen, Escherichia coli (E. coli). Therefore, the objective of this study was to compare in vitro killing activities and times of enrofloxacin alone to its combination with doxycycline, against ten E. coli isolates derived from dogs and cats using time-kill curves. The combinations were tested into two ways - simultaneous and separated combinations (12-hour interval). The results showed that enrofloxacin alone could kill E. coli best with a log reduction of 3.96±0.49 (97.96-100.00% kill) within two hours, followed by the simultaneous combination with a log reduction of 3.78±0.37 (98.73-100.00% kill) within six hours, and the separated combination with a log reduction of 3.51±0.47 (99.19-100.00% kill) after 12 hours of enrofloxacin exposure. Moreover, when comparing time to 3 log reduction (T3K), the separated combination killed E. coli significantly slower than that of enrofloxacin alone (8.04±0.94 Vs 2.47±0.40 hours, P<0.05), which was consistent with the results of time to elimination (TE) (14.97±1.35 Vs 5.83±0.58 hours, P<0.05). From this study, it can be concluded that the killing activity of enrofloxacin is reduced and delayed especially by the presence of doxycycline 12 hours prior to enrofloxacin. The findings in this study can be applied to predicting clinical outcomes from the use of enrofloxacin and doxycycline combination and to studying more about drug interaction between these two classes of antibacterial drugs in the future.
Analisis Nilai-Nilai Pendidikan Islam Pada Tradisi Nganggung di Bangka Belitung
Authors: Maryamah Maryamah , Safitri Aisyah , Salsa Bella Hanum , Sabina Rini 
Published: November 2023

Tradisi Nganggung berasal dari Kepulauan Bangka Belitung, Dalam tradisi nganggung masyarakat yang berkumpul untuk menyediakan makanan dari rumahnya masing-masing ke tempat tertentu (hajatan) untuk dimakan bersama setelah ritual agama dan terlihat ikut serta dalam kegiatan gotong royong. Dalam hubungan dengan pendidikan Islam, budaya Nganggung di Bangka Belitung memiliki nilai-nilai yang penting untuk dianalisis. Nilai-nilai tersebut mencerminkan ajaran agama Islam yang diimplementasikan dalam kehidupan sehari-hari masyarakat setempat. Tujuan penelitian ini adalah untuk mengetahui nilai nilai-nilai pendidikan islam dalam tradisi nganggung Bangka Belitung. Metode yang digunakan dalam penelitian ini adalah motode kualitatif dengan teknik pengunmpulan data melalui kuesioner digoogle form. Hasil dari penelitian ini bahwa nilai-nilai pendidikan islam dalam tradisi nganggung antara lain; nilai silahturami (Ukhuwah Islamiyah), tolong menolong (Ta’awun) dan berbagi kasih sayang (Tarhum) serta meningkatkan akidah akhlak. Dari tradisi ini dampak positif yang ditimbulkan adalah meningkatkan kebersamaan, meningkatkan ukhuwah islamiyah, mempertahankan tradisi, mendapatkan ridho ilahi, dan solidaritas komunitas.
Refined scan protocol for the evaluation of pulmonary perfusion standardized image quality and reduced radiation dose in dynamic chest radiography
Authors: Takakura Kenta , Yamasaki Yuzo , Kuramoto Taku , Yoshidome Satoshi , Hida Tomoyuki , Kamitani Takeshi , Yoshikawa Hideki , Kato Toyoyuki , Ishigami Kousei 
Published: November 2023

AbstractPurposeDynamic chest radiography (DCR) is a novel imaging technique used to noninvasively evaluate pulmonary perfusion. However, the standard DCR protocol, which is roughly adapted to the patient's body size, occasionally causes over‐ or underexposure, which could influence clinical evaluation. Therefore, we proposed a refined protocol by increasing the number of patient body mass index (BMI) categories from three to seven groups and verified its usefulness by comparing the image sensitivity indicators (S‐values) and entrance surface doses (ESDs) of the conventional protocol with those of our refined protocol.MethodsThis retrospective observational study included 388 datasets (standing position, 224; supine position, 164) for the conventional protocol (December 2019–April 2021) and 336 datasets (standing position, 233; supine position, 103) for the refined protocol (June–November 2021). The conventional protocol (BMI‐3 protocol) divided the patients into three BMI groups (BMI < 17, 17≤BMI < 25, and BMI ≥ 25 kg/m2), whereas the refined protocol (BMI‐7 protocol) divided the patients into seven BMI groups (BMI < 17, 17 ≤ BMI < 20, 20 ≤ BMI < 23, 23 ≤ BMI < 26, 26 ≤ BMI < 29, 29 ≤ BMI < 32, and BMI ≥ 32 kg/m2). The coefficients of variation (CVs) for the S‐values and ESDs acquired using the two protocols were compared.ResultsThe CVs of the S‐values in the BMI‐7 protocol group were significantly lower than those in the BMI‐3 protocol group for the standing (28.8% vs. 16.7%; p < 0.01) and supine (24.5% vs. 17.7%; p < 0.01) positions. The ESDs of patients scanned using the BMI‐7 protocol were significantly lower than those scanned using the BMI‐3 protocol in the standing (1.3 vs. 1.1 mGy; p < 0.01) and supine positions (2.5 vs. 1.6 mGy; p < 0.01), although the mean BMI of the two groups were similar.ConclusionWe introduced the BMI‐7 protocol and demonstrated its standardized image quality and reduced radiation exposure in patients undergoing DCR.
Optimization Strategies of Covalent Organic Frameworks and Their Derivatives for Electrocatalytic Applications
Authors: Xiao Liyuan , Wang Zhenlu , Guan Jingqi 
Published: November 2023

AbstractCovalent organic frameworks (COFs) are crystalline organic porous polymers that can be precisely integrated by building blocks to achieve pre‐designed composition, components, and functions, making them a powerful platform for the development of molecular devices in the field of electrocatalysis. The precise control of channel/dopant positions and highly ordered network structures of COFs provide an ideal material system for the applications of advanced electrocatalysis. In this paper, the topological structure design and synthesis methods of COFs are reviewed in detail, and their design principles are deeply analyzed. In addition, the applications of COFs and their derivatives in the field of electrocatalysis are systematically summarized and the optimization strategies are proposed. Finally, the application prospects of COFs and their derivatives in electrocatalysis and the challenges that may be encountered in the future are prospected, providing helpful guidance for future research.