bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroepidemiology of Human Tularemia—Systematic Review and Meta-analysis of Seroprevalence Studies
Authors: Mattatia Chantal , Agyeman Philipp K A , Schöbi Nina , Aebi Simon , Duppenthaler Andrea , Büttcher Michael , Aebi Christoph 
Published: December 2023

AbstractBackgroundSeroepidemiologic studies of human tularemia have been conducted throughout the northern hemisphere. The purposes of this study were (1) to provide an overview of Francisella tularensis seroprevalence data, and (2) to generate an estimate of the proportion of study participants whose infection remained subclinical.MethodsWe conducted a systematic review of F tularensis seroprevalence studies according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We searched PubMed, Embase, and Web of Science covering the period from 1951 to 2023.ResultsThe weighted pooled seroprevalence among 44 486 participants recruited in 52 studies was 3.7% (95% confidence interval [CI], 2.7–5.1). Reported seroprevalences ranged between 0.2% and 31.3%. Occupational activities associated with an increased likelihood of exposure (risk ratio, 3.51 [95% CI, 3.2–3.86]) and studies from North America versus Europe and Asia (4.53 [4.15–4.94]) were associated with significantly increased seropositive rates. Twenty-eight data sets (47%) reported clinical information on a total of 965 seropositive participants. The weighted pooled estimate for subclinical seropositivity was 84.4% (95% CI, 72.9%–991.7%). Studies from F tularensis type A areas (risk ratio, 0.37 [95% CI, .27–.51) and studies from sites where pulmonary tularemia prevailed (0.38 [.28–.51]) reported lower subclinical seropositivity rates than studies from type B areas and from areas of predominance of (ulcero)glandular or oropharyngeal tularemia, respectively.ConclusionsThroughout the northern hemisphere, only a small proportion of study participants showed serologic evidence of exposure to F tularensis. Eight of 10 seropositive participants had no historical evidence of past clinical tularemia.
Macro-Level Pluralism
Authors: Rubin Ruth Bloch , Elinson Gregory , TerBeek Calvin 
Published: December 2023

Abstract
As is true of many social-scientific traditions, political history is populated by scholars who run the methodological gamut, from those who rely on finely textured narrative accounts to those who employ advanced computational tools, statistical analyses, and formal models. But, as this chapter argues, what is distinctive about political history is that its methodological pluralism is a feature of the field in aggregate, rather than a characteristic of its most influential component studies. This macro-level pluralism has helped political historians to address some of the fundamental challenges of working with historical data. Perhaps more importantly, it represents a profitable alternative to the way political scientists have tended to think about mixed-methods research.
The spatiotemporal pattern of surface ozone and its impact on agricultural productivity in China
Authors: Chen Xiaoguang , Gao Jing , Chen Luoye , Khanna Madhu , Gong Binlei , Auffhammer Maximilian 
Published: December 2023

Abstract
The slowing of agricultural productivity growth globally over the past two decades has brought a new urgency to detect its drivers and potential solutions. We show that air pollution, particularly surface ozone (O3), is strongly associated with declining agricultural total factor productivity (TFP) in China. We employ machine learning algorithms to generate estimates of high-resolution surface O3 concentrations from 2002 to 2019. Results indicate that China's O3 pollution has intensified over this 18-year period. We coupled these O3 estimates with a statistical model to show that rising O3 pollution during nonwinter seasons has reduced agricultural TFP by 18% over the 2002–2015 period. Agricultural TFP is projected to increase by 60% if surface O3 concentrations were reduced to meet the WHO air quality standards. This productivity gain has the potential to counter expected productivity losses from 2°C warming.
A tomato bushy stunt virus–based vector for simultaneous editing and sensing to survey the host antiviral RNA silencing machinery
Authors: DeMell April , Mendoza Maria R , Scholthof Herman B 
Published: December 2023

Abstract
A tomato bushy stunt virus (TBSV)–derived vector system was applied for the delivery of CRISPR/Cas9 gene editing materials, to facilitate rapid, transient assays of host–virus interactions involved in the RNA silencing pathway. Toward this, single guide RNAs designed to target key components of the virus-induced host RNA silencing pathway (AGO2, DCL2, HEN1) were inserted into TBSV-based GFP-expressing viral vectors TBSV-GFP (TG) and its P19 defective mutant TGΔP19. This produced rapid, efficient, and specific gene editing in planta. Targeting AGO2, DCL2, or HEN1 partially rescued the lack of GFP accumulation otherwise associated with TGΔP19. Since the rescue phenotypes are normally only observed in the presence of the P19 silencing suppressor, the results support that the DCL2, HEN1, and AGO2 proteins are involved in anti-TBSV RNA silencing. Additionally, we show that knockdown of the RNA silencing machinery increases cargo expression from a nonviral binary Cas9 vector. The TBSV-based gene editing technology described in this study can be adapted for transient heterologous expression, rapid gene function screens, and molecular interaction studies in many plant species considering the wide host range of TBSV. In summary, we demonstrate that a plant virus can be used to establish gene editing while simultaneously serving as an accumulation sensor for successful targeting of its homologous antiviral silencing machinery components.
Real-time monitoring of the amyloid β1–42 monomer-to-oligomer channel transition using a lipid bilayer system
Authors: Numaguchi Yuri , Tsukakoshi Kaori , Takeuchi Nanami , Suzuki Yuki , Ikebukuro Kazunori , Kawano Ryuji 
Published: December 2023

Abstract
This study describes the observation of the transformation of monomeric amyloid β1–42 (Aβ42) into oligomers in a lipid membrane utilizing a lipid bilayer system for electrophysiological measurement. The relevance of oligomers and protofibrils in Alzheimer's disease (AD) is underscored given their significant neurotoxicity. By closely monitoring the shift of Aβ42 from its monomeric state to forming oligomeric channels in phospholipid membranes, we noted that this transformation transpired within a 2-h frame. We manipulated the lipid membrane's constitution with components such as glycerophospholipid, porcine brain total lipid extract, sphingomyelin (SM), and cholesterol (Chol.) to effectively imitate nerve cell membranes. Interesting findings showcased Chol.'s ability to foster stable oligomeric channel formation in the lipid membrane, with SM and GM1 lipids potentially enhancing channel formation as well. Additionally, the study identified the potential of a catechin derivative, epigallocatechin gallate (EGCG), in obstructing oligomerization. With EGCG present in the outer solution of the Aβ42-infused membrane, a noteworthy reduction in channel current was observed, suggesting the successful inhibition of oligomerization. This conclusion held true in both, prior and subsequent, stages of oligomerization. Our findings shed light on the toxicity of oligomers, promising invaluable information for future advancements in AD treatment strategies.
Migration and the Value of Social Networks
Authors: Blumenstock Joshua E , Chi Guanghua , Tan Xu 
Published: December 2023

Abstract
How do social networks influence the decision to migrate? Prior work suggests two distinct mechanisms that have historically been difficult to differentiate: as a conduit of information, and as a source of social and economic support. We disentangle these mechanisms using a massive “digital trace” dataset that allows us to observe the migration decisions made by millions of individuals over several years, as well as the complete social network of each person in the months before and after migration. These data allow us to establish a new set of stylized facts about the relationship between social networks and migration. Our main analysis indicates that the average migrant derives more social capital from “interconnected” networks that provide social support than from “extensive” networks that efficiently transmit information.
Oral Nifedipine Versus Intravenous Labetalol for Hypertensive Emergencies During Pregnancy: A Systematic Review and Meta-analysis
Authors: Li Lin , Xie Wenxia , Xu Hao , Cao Lei 
Published: December 2023

(Abstracted from J Matern Fetal Neonatal Med 2023;36(2):2235057)
Hypertensive disorders of pregnancy are a leading cause of maternal and perinatal death. Severe pregnancy hypertension is defined as 160/110 mm Hg.
Efficacy of minimally invasive reduction with cerclage fixation in spiral or oblique subtrochanteric femoral fractures: A retrospective cohort study comparing cables and wires
Authors: Kook Incheol , Park Ki-Chul , Kim Keong Yoon , Jung Ilyun , Hwang Kyu Tae 
Published: December 2023

OBJECTIVE:
To compare the outcomes of a minimally invasive reduction (MIR) technique using a cable and a wire in spiral or oblique subtrochanteric femoral fractures (SFF).
METHODS

Design:
Retrospective cohort study

Setting:
Two University Hospitals

Patient Selection Criteria:
Skeletally mature patients with spiral or oblique SFF (OTA/AO 32A1 and 32A2) treated with intramedullary nailing and MIR with a cerclage wire passer using either a single-loop cable or cerclage wire or MIR without cable or wire between May 2016 and November 2021.
Outcome Measures and Comparisons: Coronal and sagittal interfragmentary gap, neck-shaft angle, coronal and sagittal angulation, fracture union, time to union, and Radiographic Union Score for Hip (RUSH) at 6 months post-operation were compared.

RESULTS:
A total of 46 patients were included, with 16 each in the cable and wire groups and 14 in the non-wiring group. There were no differences in demographics (p>0.05), fracture classification (p=0.710), or operative data (p>0.05) between the three groups. The cable group showed significantly better coronal (p=0.003) and sagittal (p=0.003) interfragmentary gap, shorter union time (p<0.001), and higher 6-month RUSH score (p<0.001) among the three groups. There were no significant differences in outcome measures between the wire and non-wiring groups (all p>0.05). No mechanical complications or reoperations were observed in all three groups.

Conclusions:
Minimally invasive reduction using a cable is more effective than wire or non-wiring reduction to improve reduction quality and promote bone union in SFF.

Level of evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Prediction of Long-Term Physical, Mental, and Cognitive Problems Following Critical Illness: Development and External Validation of the PROSPECT Prediction Model*
Authors: van Sleeuwen Dries , Zegers Marieke , Ramjith Jordache , Cruijsberg Juliette K. , Simons Koen S. , van Bommel Daniëlle , Burgers-Bonthuis Dominique , Koeter Julia , Bisschops Laurens L. A. , Janssen Inge , Rettig Thijs C. D. , van der Hoeven Johannes G. , van de Laar Floris A. , van den Boogaard Mark 
Published: December 2023

OBJECTIVES:
ICU survivors often suffer from long-lasting physical, mental, and cognitive health problems after hospital discharge. As several interventions that treat or prevent these problems already start during ICU stay, patients at high risk should be identified early. This study aimed to develop a model for early prediction of post-ICU health problems within 48 hours after ICU admission.

DESIGN:
Prospective cohort study in seven Dutch ICUs.

SETTING/PATIENTS:
ICU patients older than 16 years and admitted for greater than or equal to 12 hours between July 2016 and March 2020.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Outcomes were physical problems (fatigue or ≥ 3 new physical symptoms), mental problems (anxiety, depression, or post-traumatic stress disorder), and cognitive impairment. Patient record data and questionnaire data were collected at ICU admission, and after 3 and 12 months, of 2,476 patients. Several models predicting physical, mental, or cognitive problems and a composite score at 3 and 12 months were developed using variables collected within 48 hours after ICU admission. Based on performance and clinical feasibility, a model, PROSPECT, predicting post-ICU health problems at 3 months was chosen, including the predictors of chronic obstructive pulmonary disease, admission type, expected length of ICU stay greater than or equal to 2 days, and preadmission anxiety and fatigue. Internal validation using bootstrapping on data of the largest hospital (n = 1,244) yielded a C-statistic of 0.73 (95% CI, 0.70–0.76). External validation was performed on data (n = 864) from the other six hospitals with a C-statistic of 0.77 (95% CI, 0.73–0.80).

CONCLUSIONS:
The developed and externally validated PROSPECT model can be used within 48 hours after ICU admission for identifying patients with an increased risk of post-ICU problems 3 months after ICU admission. Timely preventive interventions starting during ICU admission and follow-up care can prevent or mitigate post-ICU problems in these high-risk patients.
Semiparametric Allocation of Subjects to Cohort Strata
Authors: Walker Alexander M. , Russo Massimiliano , Schneeweiss Maria C. , Glynn Robert J. 
Published: December 2023

Background:
We illustrate a method for stratum assignment in small cohort studies that avoids modeling assumptions.

Methods:
Off-the-shelf software (rgenoud) made stratum assignments to minimize a loss function built on within-stratum and population-adjusted Euclidean distances.

Results:
In 100 trials using simulated data of 300 records with a binary treatment and four dissimilar covariate treatment predictors, minimizing a loss based on Euclidean distance reduced covariate imbalance by a median of 99%. Stratification by propensity score and weighting records by the inverse of their probability of treatment reduced imbalance by 76%–89% and 83%–94%, respectively. Loss minimization applied to a cohort of 361 children undergoing immunotherapy achieved nearly complete elimination of covariate differences for important treatment predictors.

Conclusion:
With the availability of semiparametric stratum-assignment algorithms, analysts can tailor loss functions to meet design goals. Here, a loss function that emphasized covariate balance performed well under limited testing.
Intrahepatic neutrophil accumulation and extracellular trap formation are associated with posthepatectomy liver failure
Authors: Brunnthaler Laura , Pereyra David , Brenner Miriam , Santol Jonas , Herrmann Lukas , Schrottmaier Waltraud C. , Pirabe Anita , Schmuckenschlager Anna , Kim Sarang , Kern Anna Emilia , Huber Felix Xaver , Michels Lisa Emilie , Brostjan Christine , Salzmann Manuel , Hohensinner Philipp , Kain Renate , Gruenberger Thomas , Starlinger Patrick , Assinger Alice 
Published: December 2023

Background:
Posthepatectomy liver failure (PHLF) represents a life-threatening complication with limited therapeutic options. Neutrophils play a critical and dynamic role during regeneratory processes, but their role in human liver regeneration is incompletely understood, especially as underlying liver disease, detectable in the majority of patients, critically affects hepatic regeneration. Here we explored intrahepatic neutrophil accumulation and neutrophil extracellular traps (NETs) in patients with PHLF and validated the functional relevance of NETs in a murine partial hepatectomy (PHx) model.

Methods:
We investigated the influx of neutrophils, macrophages, eosinophils, and mast cells and the presence of their respective extracellular traps in liver biopsies of 35 patients undergoing hepatectomy (10 patients with PHLF) before and after the initiation of liver regeneration by fluorescence microscopy. In addition, NET formation and neutrophil activation were confirmed by plasma analysis of 99 patients (24 patients with PHLF) before and up to 5 days after surgery. Furthermore, we inhibited NETs via DNase I in a murine PHx model of mice with metabolically induced liver disease.

Results:
We detected rapid intrahepatic neutrophil accumulation, elevated levels of myeloperoxidase release, and NET formation in regenerating human livers, with a significantly higher increase of infiltrating neutrophils and NETs in patients with PHLF. Circulating markers of neutrophil activation, including elastase, myeloperoxidase, and citrullinated histone H3, correlated with markers of liver injury. In a murine PHx model, we showed that the inhibition of NET accelerated hepatocyte proliferation and liver regeneration.

Conclusions:
Patients with PHLF showed accelerated intrahepatic neutrophil infiltration and NET formation, which were associated with liver damage. Further, we identified postsurgical myeloperoxidase levels as predictive markers for adverse outcomes and observed that blocking NETs in a murine PHx model accelerated tissue regeneration.
BILATERAL UVEITIS, RETINAL PERIPHLEBITIS, AND OPTIC NEURITIS ASSOCIATED WITH NON-PINEAL CENTRAL NERVOUS SYSTEM GERMINOMA
Authors: Liu Tianyu , Chebolu Apoorv P. , Chung Caroline W. , Kruszewski Adam M. , Bhatt Nirali , Brucker Alexander J. 
Published: December 2023

Purpose:
The aim of this study was to report a case of bilateral uveitis, retinal periphlebitis, and optic neuritis associated with a non-pineal central nervous system germinoma.

Methods:
This is a case report.

Results:
A 32-year-old man presented with episodes of acute painless visual disturbance in each eye and was found to have decreased VA, abnormal color vision, an afferent pupillary defect in the left eye, bilateral optic disc edema, perivenous sheathing, and candle-wax dripping exudates. Optical coherence tomography revealed bilateral intraretinal fluid and posterior vitreous hyperreflective opacities. Fluorescein angiography revealed bilateral optic disc leakage without active small vessel leakage. Magnetic resonance imaging of the brain and orbits revealed enhancing periventricular lesions and enhancement of the left optic nerve and bilateral perioptic nerve sheaths, posterior globes, and optic nerve heads. Brain biopsy was consistent with a central nervous system germinoma. His ocular signs and symptoms improved with chemotherapy for the germinoma.

Conclusion:
Central nervous system germinomas, including those located outside the pineal region, can be associated with optic neuritis, uveitis, and periphlebitis including characteristic candle-wax dripping exudates. Ocular signs and symptoms typically improve with treatment of the underlying germinoma.
Assessing the role of robotic surgery versus laparoscopic surgery in patients with a diagnosis of endometriosis: A meta-analysis
Authors: Song Zhihua , Li Songtao , Luo Mei , Li Hongjun , Zhong Hanzhi , Wei Shaobin 
Published: December 2023

Background:
Surgical management of endometriosis can be carried out with the traditional standard laparoscopic technique or the robotic surgery technique; however, it is not clear if there is a significant difference between techniques. This meta-analysis aims to evaluate and compare the impact of robotic and standard laparoscopic techniques in endometriosis regarding the clinical outcome.

Methods:
Studies comparing robotic surgery to laparoscopic surgery for endometriosis were among the studies from various languages that met the inclusion criteria. Using dichotomous and continuous random-effect models, the results of these investigations (surgery time, hospitalization time, blood loss, complications, and conversion rate) were examined, and the mean difference with 95% confidence intervals was computed.

Results:
Eight studies from 2013 to 2022 were selected for the current analysis including 1741 patients with endometriosis. The studied data revealed a statistically significant (P = .01) lower operation time related to laparoscopic surgery compared with the robotic technique. In addition, the hospitalization time of laparoscopic surgery is significantly (P = .03) lower than that of robotic surgery. On the other hand, blood loss, rehospitalization, postoperative and intraoperative complications, and conversion rates were not significantly different between both techniques. Heterogeneity values were variable according to the analysis factor, from 0% to 91%.

Conclusion:
Both robotic and standard laparoscopic techniques have similar outcomes regarding blood loss, rehospitalization, conversion rate, and rate of complication. However, the substantial difference between techniques was in favor of standard laparoscopic surgery regarding operation and hospitalization time.
The effect of music therapy on tinnitus: A systematic review
Authors: Niu Yunlian , You Yijie 
Published: December 2023

Objectives:
Tinnitus is a common otological symptom affecting almost all aspects of life, especially the quality of daily life. The present study aims to analyze music therapy effect on tinnitus patients. This paper mainly analyzes 3 kinds of music therapy: Heidelberg model of music therapy (HMOMT), standard music therapy (SMT), and tailor-made notched music training (TMNMT). To provide a reference for the follow-up treatment of tinnitus, whether to take and what kind of music therapy.

Method:
A systematic literature search was performed in PubMed, Cochrane Library, EMBASE, Web of Science, and MEDLINE to obtain potential studies from their inception to May 2023 in all languages. Two researchers independently screened the studies, extracted data, and assessed the quality of the included studies. We included all randomized and non-randomized controlled trials that used music therapy to treat patients with tinnitus. We used fixed-effects and random-effect models to analyze data based on the heterogeneity results. The data analysis was performed by using Stata 12.0.

Results:
A total of 19 studies with 904 cases were included. Compared with before treatment, music therapy significantly reduces the tinnitus questionnaire score and tinnitus handicap inventory score. HMOMT, SMT, and TMNMT all significantly decrease tinnitus scores. Although the order of effectiveness of the 3 drugs is TMNMT > SMT > HMOMT, there is no statistical significance (P > .5).

Conclusion:
This meta-analysis of accumulated clinical trial data suggests that music therapy can relieve tinnitus symptoms and loudness. Among music therapies, SMT is recommended first for tinnitus based on cost, efficacy, and convenience. At the same time, TMNMT and HMOMT can be used as alternative therapies for specific cases.