bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome in patients with HIV-associated Hodgkin lymphoma treated with chemotherapy using Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine in the combination antiretroviral therapy (cART) era: results of a multicenter study from China
Authors: Xiao Lirong , Wang Chaoyu , Ma Sai , Wang Yifan , Guan Liping , Wu Juyi , Zhang Wei , Liu Yao , Wu Yan 
Published: January 2024

Abstract
Little is known about the outcome for HIV-associated Hodgkin lymphoma (HIV-HL) as these are less common than HIV-negative lymphoma. Therefore, we performed a multi-center study to analyze the clinical characteristics and outcomes of HIV-HL patients in China. Nineteen cases of HIV-HL were diagnosed and treated at three center, which including the sixth people’s hospital of Zhengzhou, Peking union medical college hospital, and Chongqing university cancer hospital, between December 2013 and June 2022. Data on the clinical features, laboratory results, response, and prognosis were collected and analyzed. The median age at diagnosis was 43(22–74) years. All patients were infected with HIV through sexual transmission, with ten cases transmitted through man sex with man (MSM) and nine cases transmitted through heterosexual transmission. Seven patients were diagnosed with lymphoma and found to be infected with HIV. Four cases were in stage III, and fifteen cases were in stage Ⅳ. After a median follow up of 46.8(4.0-112.9) months, 17 cases were alive after ABVD regimen chemotherapy combined with the combination antiretroviral therapy (cART). The 5-year PFS and OS rate were 83.9% and 89.5%,respectively. HIV-HL exhibit an invasive process in clinical practice, and cART combined with ABVD regimen chemotherapy can achieve long-term survival for patients.
Chromophobe renal cell carcinoma with sarcomatoid differentiation: A case report with molecular analysis
Authors: AHN AE RI , Jeong Young Bum , Kim Kyoung Min 
Published: January 2024

Abstract

Background
Chromophobe renal cell carcinoma is a rare type of kidney cancer with a favorable prognosis. Renal cell carcinoma with sarcomatoid change has a more aggressive clinical course with unelucidated pathogenesis.
Case presentation
A 54-year-old female patient presented to the urology department for evaluation of an incidentally detected left renal mass. Computed tomography demonstrated a 13x10-cm mass in the left upper pole of the kidney. The resected tumor was clearly divided into two distinct components: one showed conventional Chromophobe renal cell carcinoma morphology, while the tumor cells of the other were highly pleomorphic with poorly differentiated morphology. The poorly differentiated component showed immunohistochemical expression for cytokeratin. Next-generation sequencing (NGS) of the two components shared multiple chromosomal losses and variation in the RNF46 gene. Based on these findings, we diagnosed the tumor as Chromophobe renal cell carcinoma with sarcomatoid change. Although the two components shared some genetic changes, there were also significant differences. The area of sarcomatoid change carried chromosomal gain, single nucleotide variants, and MET fusion compared with the conventional Chromophobe renal cell carcinoma component. Furthermore, while PD-L1 was negative in the conventional Chromophobe renal cell carcinoma component, more than 10% of the tumor cells in the sarcomatoid component were PD-L1 positive.
Conclusion
This case reveals novel genetic features of chromophobe renal cell carcinoma with sarcomatoid change.
Nuclear accumulated μ-calpain in AT2 cell participates in pulmonary fibrosis via inactivating FoxO3a
Authors: LI Qiao , YE Yu-Tong , ZHU Yi-Liang , TIAN Yu , WANG Miao-Feng , FANG Yuan , HAN Lu-Yao , ZHANG Ran-Ran , HUANG Xiao , ZHOU Jing-Jun , ZHAO Feng 
Published: January 2024

Abstract
µ-calpain is implicated in pulmonary fibrosis, however its role in the aberrant differentiation of alveolar epithelial type II cells (AT2), a hallmark of pulmonary fibrosis remains unclear, and its targeted transcription factor has not been addressed. Here, examination of the specimen of fibrosis patients revealed excessive proliferation of AT2 cells. In parallel, AT2 cells exhibited substantial calpain 1 (CAPN1), a catalytic subunit of µ-calpain, and phosphorylated FoxO3a (p-FoxO3a), an important transcription factor in lung tissue. Of note, targeted knockdown of CAPN1 in AT2 cells blocked the progression of bleomycin-induced pulmonary fibrosis, manifested as reduced poorly aerated regions in chest CT image, and decreased content of hydroxyproline and α-SMA. Analysis of nuclear fraction displayed an accumulation of CAPN1 and loss of FoxO3a, which was accompanied with activation of Akt. Knockdown of CAPN1 in A549 cells with siRNA antagonized the process of epithelial-mesenchymal transition and blunted FoxO3a phosphorylation and Akt activation. Conversely, overexpression of CAPN1 accelerated mesenchymal transition, enhanced its nuclear accumulation and the translocation of p-FoxO3a out of nucleus. Finally, inhibition of Akt decreased calpain-elicited FoxO3a phosphorylation, meanwhile, transfection of FoxO3a mutant carrying Thr32A and Ser253A mitigated the calpain-stimulated mesenchymal transition. Collectively, we conclude that nuclear accumulation of µ-calpain in AT2 cells is a critical step to aggravate pulmonary fibrosis. we also identify that inactivation of FoxO3a in a Akt-dependent phosphorylation manner confers to calpain-elicited the aberrant differentiation of AT2 cells.
A randomized controlled trial to compare the effects of time-restricted eating vs. Mediterranean diet on symptoms and quality of life in bipolar disorder
Authors: Johnson Sheri L , Murray Greg , Kriegsfeld Lance J. , Manoogian Emily , Mason Liam , Allen J. D. , Berk Michael , Panda Satchidanda , Rajgopal Nandini A. , Gibson Jake C. , Joyner Keanan , Villanueva Robert , Michalak Erin E. 
Published: January 2024

Abstract
Background: The primary objective of this randomized controlled trial (RCT) is to establish the effectiveness of time-restricted eating (TRE) compared with the Mediterranean diet for people with bipolar disorder (BD) who have symptoms of sleep disorders or circadian rhythm sleep-wake disruption. This work builds on the growing evidence that TRE has benefits for improving circadian rhythms. TRE and Mediterranean diet guidance will be offered remotely using self-help materials and an app, with coaching support.
Methods: This study is an international RCT to compare the effectiveness of TRE and the Mediterranean diet. Three hundred participants will be recruited primarily via social media. Main inclusion criteria are: receiving treatment for a diagnosis of BD I or II (confirmed via MINI structured diagnostic interview), endorsement of sleep or circadian problems, self-reported eating window of ≥ 12 hours, and no current mood episode, acute suicidality, eating disorder, psychosis, alcohol or substance use disorder, or other health conditions that would interfere with or limit the safety of following the dietary guidance. Participants will be asked to complete baseline daily food logging for two weeks and then will be randomly allocated to follow TRE or the Mediterranean diet for 8 weeks, during which time, they will continue to complete daily food logging. Intervention content will be delivered via an app. Symptom severity interviews will be conducted at baseline; mid-intervention (4 weeks after the intervention begins); end of intervention; and at 3, 6, and 12 months postintervention by phone or videoconference. Self-rated symptom severity and quality of life data will be gathered at those timepoints, as well as at 6 weeks postintervention. To provide a more refined index of whether TRE successfully decreases emotional lability and improves sleep, participants will be asked to complete a sleep diary (core CSD) each morning and complete six mood assessments per day for eight days at baseline and again at mid-intervention.
Discussion: The planned research will provide novel and important information on whether TRE is more beneficial than the Mediterranean diet for reducing mood symptoms and improving quality of life in individuals with BD who also experience sleep or circadian problems.
Trial registration: ClinicalTrials.gov: ID: 2022-10-15725. Pending, submitted 12/17/2023.
Effect of colchicine on cancer risk in patients with the musculoskeletal system and connective tissue and rheumatism-related diseases
Authors: Yeh Jun-Jun , Liw Pei-Xuan , Wong Yi-Sin , Kao Husan-Min , Lee Chia-Hsun , Lin Cheng-Li , Kao Chia-Hung 
Published: January 2024

Abstract
Background To determine the effect of colchicine on cancer risk in patients with the musculoskeletal system and connective tissue and rheumatism-related diseases (MD).Methods We retrospectively enrolled patients with the MD divided them into colchicine users (N = 16,026) and colchicine nonusers (N = 16,026). Furthermore, time-dependent Cox models were used to analyze cancer risk in propensity-matched colchicine users compared with the nonusers. The cumulative cancer incidence was analyzed using Cox proportional regression analysis. We calculated adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) for cancer after adjusting for sex, age, comorbidities, and use of medicine including acetylcysteine, medication for tobacco use, anti-inflammatory drugs and immunosuppressant drugs.Results Comparing the colchicine nonusers, only the colchicine users were associated with the lower incidence of the colorectal cancer ( (aHRs) (95% CI), 0.52 (0.49, 0.89)). Notably, the frequency of the medical services may inflate the aHR of brain tumor ((aHRs (95% CI), 8.42 (1.32, 53.9)). However, the aged < 65 years adult having the colchicine users were associated with lower risk the colorectal cancer. Moreover, the colchicine > 20 days use with the lower aHR for colorectal cancer.Conclusion This study implied colchicine with an auxiliary role for protecting the colorectal cancer formation in patients with the musculoskeletal system and connective tissue and rheumatism-related diseases.
HIF-1α inhibitor protects against cigarette smoke-induced COPD development in mice
Authors: Zhang Kedong , Zhou Feng , Zhu Caixia , Yuan Liang , Li Defu , Wang Jian , Lu Wenju 
Published: January 2024

Abstract

Hypoxia-inducible factor-1α (HIF-1α) plays an important regulatory role in inflammatory and hypoxic diseases. Higher HIF-1α level was found in lungs of chronic obstructive pulmonary disease (COPD) patients, however, its role in cigarette smoke (CS)-induced COPD has not been fully studied. Digoxin has been showed to inhibit HIF-1α translation and block HIF-1α activity and thus is often used as the HIF-1α inhibitor. Therefore, in the present study, we chose digoxin as the inhibitor to investigate whether HIF-1α contributes to the progression in a mouse model of COPD and possible mechanism. CS-exposed mice were intragastrically treated with different doses of digoxin(0.02mg/kg and 0.1mg/kg, once a day, and COPD associated phenotypes such as pathological changes in lungs, inflammation, lung function and mucus secretion in airways were evaluated. Meanwhile, cigarette smoke extract (CSE)-treated A549 cells were administrated with digoxin(50nM) or S7959(100uM). Moreover, epithelial mesenchymal transition(EMT) associated markers together with HIF-1α\TGF-β1\Smad3 signaling pathway were detected both in vivo and in vitro. The level of HIF-1α was significantly increased in lungs of COPD mice and CSE-exposed A549 cells, which was markedly suppressed by digoxin. Moreover, digoxin inhibited CS-induced inflammatory responses, lung function decline, and mucus hyper-secretion in COPD mouse model. In in vitro studies, digoxin decreased CSE-induced pro-inflammatory cytokine release. Importantly, CS-induced or CSE-induced EMT and up-regulation of HIF-1α/TGF-β1/Smad pathway was inhibited by digoxin in vitro. Additionally, S7959 mitigated CSE-induced EMT in A549 cells. Digoxin can protect CS-induced COPD and prevent CS-induced EMT possibly through HIF-1α/TGF-β1/Smad3 signaling pathway in mice. This study suggests HIF1-α could be a potential intervention target for COPD prevention and treatment, especially for EMT in CS-induced COPD.
Numerical investigation on thermal-hydraulic performance of cryogenic LNG in sinusoidal channel with airfoil fins under marine dynamic load
Authors: Tian Zhen , Chen Xiangjie , Zhao Bo , Shen Weili , Peng Hao 
Published: January 2024

Abstract

For floating liquefied natural gas (FLNG), printed circuit heat exchanger (PCHE) is an optimal choice owing to its compactness and large temperature difference heat transfer in a short time. In this study, a novel sinusoidal channel configuration was established which is with airfoil fins, and its thermal-hydraulic performance was numerically studied. The Nusselt number and Fanning friction factor were studied. Meanwhile, the effects of marine dynamic load and inlet mass flow rate (IMFR) on the novel configuration were studied by numerical simulation. Considering the application scenarios of the PCHE, the supercritical LNG (S-LNG) with 113.15 K and 32 MPa was the cold fluid, and the ethylene glycol with 293.15 K and 0.1 MPa was the hot fluid. The results show that the novel configuration has better comprehensive performance. The local turbulent kinetic energy of the novel configuration is improved by about 19.78%. The temperature and velocity uniformity are improved. Marine dynamic load deteriorates the comprehensive performance of the novel configuration. With the increasing of the IMFR, the outlet temperature for S-LNG gradually decreases from 240.65 K to 186.70 K, while the pressure drop and turbulent kinetic energy increase from 6969.72 Pa to 23225.75 Pa and 0.0256 m2/s2 to 0.12874 m2/s2, respectively. This work can provide valuable guidance for PCHE under cryogenic and supercritical pressure working condition in engineering applications.
Validation of the I- and D-type Epistemic Curiosity scale among Young Chinese Children and Implications on Early Curiosity Nurture
Authors: Tang Shuang , Xu Tianwei , Jin Lingyan , Chen Qunlin , Qiu Jiang 
Published: January 2024

Abstract
Curiosity, an innate and intrinsic motivation to explore, makes vital contributions to learning in individuals of various ages. Epistemic curiosity centers on the drive to close information gaps and can be classified a joyous exploration and interest (I) and deprivation sensitivity (D) types. Each subtype is associated with different academic achievements, personality traits, emotions, and aspects of creativity. Building on the concept of epistemic curiosity in adults, the I- and D-type Epistemic Curiosity in Young Children (I/D-YC) scale was developed. The purpose of the present study was to validate the Chinese I/D-YC scale for preschoolers. Exploratory factor and confirmatory factor analyses of data from 111 parents (sample 1) indicated that the Chinese I/D-YC replicated the two-factor structure and items of the original scale. The scales’ convergent validity and reliability were examined with data from 189 parents (sample 2) and 129 teachers (sample 3), as its test–retest reliability was examined with data from 45 parents (from sample 2). The results established the Chinese I/D-YC scale as a valid and reliable measure of epistemic curious behaviors in young Chinese children. Moreover, the cultivation of epistemic curiosity should weaken inhibition and this might enhance well-being, creativity and learning, especially the D type with lower SES.
The Impact of BIS-Monitored Depth Regulation on Prognosis: Improving Outcomes for Patients with Chronic DoCs
Authors: chen xuanling , qin xuewei , Zhuang Yutong , Li Zhengqian , Liang Zhenhu , zhang hua , yao lan , Li Xiaoli , He Jianghong , Guo Xiangyang 
Published: January 2024

Abstract

Background: The value of the bispectral index (BIS) for monitoring anesthesia in patients with disorder of consciousness (DoC) has not yet been determined.
Objective: To investigate the effect of BIS-monitored depth regulation on the prognosis of patients with chronic DoCs undergoing spinal cord stimulation (SCS) implantation.
Methods: Ninety-two 92 patients with DoC who underwent SCS implantation under general anesthesia were followed up for three months after surgery. Among the cohort, 83 patients met the inclusion criteria and were divided into the BIS (n = 45) and non-BIS (n = 38) groups. Relevant information was collected, along with patient characteristics. Coma recovery scale-revised (CRS-R) scores and outcomes were assessed preoperatively and three months postoperatively (CRS-R3m).
Results: In the BIS group, the CRS-R3m score was higher than the preoperative CRS-R score; however, in the non-BIS group, there was no significant difference between the scores. The CRS-R3m score in the BIS group was higher than that in the non-BIS group. Consciousness improvement was evaluated in a multifactor logistic regression analysis, which revealed that dexmedetomidine was a high-risk factor for consciousness improvement. During follow-up, two patients in the BIS group experienced a decrease in consciousness, while two patients in the non-BIS group died.
Conclusion: For patients with DoC undergoing SCS implantation under general anesthesia, intraoperative BIS monitoring to control the depth of general anesthesia sedation contributes to better postoperative outcomes. It is advisable to avoid the use of dexmedetomidine during the perioperative period, because it affects patient outcomes.
Coordination of Care for long COVID-19 Patients: A Scoping Review
Authors: DEMBELE ELODIE , MERIADE LAURENT , ROCHETTE CORINNE 
Published: January 2024

Abstract

Background Patients experiencing long COVID-19 exhibit a variety of symptoms that persist or recur following infection with severe acute respiratory coronavirus (SARS-CoV-2). While the coordination of care for patients with COVID-19 has undergone extensive analysis, the coordination of care for those with the long version of the virus has been described but not yet systematically reviewed. To address this gap, this article aims to analyze the various ways healthcare establishments and professionals coordinate the management of patients with long COVID-19.Method From March 2023, we conducted a scoping review on the coordination of care for patients with long COVID-19 using two databases, Google Scholar and PubMed. A comprehensive search was performed using specific keywords to ensure inclusivity. Relevant literature was selected based on predefined inclusion and exclusion criteria using the PICO framework.Results After deduplication, a total of 352 documents were identified, and their abstracts were examined. Subsequently, 89 references were chosen for a more detailed study. Following a thorough examination of the full text, 35 references that met the predefined inclusion criteria were retained.Conclusions The results of this scoping review identify several recommendations for the development of care coordination for patients with long COVID-19. The findings highlight numerous factors that facilitate this coordination, including multidisciplinary teams, the establishment of specialized facilities and services, identification of key players, coordination focused on patients and symptoms, rehabilitation-oriented coordination, pursuit of continuity of care, progressive identification of care pathways, and integration of e-health into the care process. These factors relate to three key areas of healthcare for these patients: care organization, types of coordination, and the operational methods of these coordinations.
Peripheral Ulcerative Keratitis Associated with Tralokinumab Therapy: A Case Report and Review of IL-13 Inhibitor-Associated Ocular Surface Disease
Authors: Maganti Nenita , Whitter Samuel A , Warner Evan J 
Published: January 2024

Abstract
Background
Dupilumab and tralokinumab are interleukin-binding monoclonal antibodies used to treat systemic atopic disease. Use of these medications in management of atopic dermatitis (AD) is known to cause conjunctivitis. Dupilumab therapy has also been associated with more severe ocular surface disease, which has not previously been described in association with tralokinumab. This report describes a case of tralokinumab-associated conjunctivitis and peripheral ulcerative keratitis and reviews the spectrum and proposed mechanisms of ocular surface disease triggered by these medications.
Case Presentation
A 61-year-old male with no rheumatologic or ocular history presented with bilateral papillary conjunctivitis and right eye peripheral ulcerative keratitis (PUK). PUK was arrested using oral corticosteroids and doxycycline, and long-term control of papillary conjunctivitis was achieved using topical tacrolimus ointment, allowing continuation of effective AD management with tralokinumab.
Conclusion
This case report documents ulcerative keratitis occurring in association with tralokinumab therapy for AD, which has previously been described with dupilumab but not tralokinumab. This report demonstrates the need for vigilant ocular surface monitoring for patients on tralokinumab and illustrates successful management and long-term control of adverse ocular events associated with this medication.
Systemic inflammation in midlife is associated with late-life functional limitations: The Atherosclerosis Risk in Communities Study
Authors: Tong Yao , Jia Yu , Gong Aobo , Li Fanghui , Zeng Rui 
Published: January 2024

Abstract

Background
Functional limitations seriously affect the quality of life of individuals. Systemic inflammation generally coexists with functional limitations. This study aims to investigate the association between systemic inflammation in midlife and the risk of functional limitations in late-life.
Methods and Results
A total of 10,044 participants were included in a cohort study, with an average age of 53.9 ± 5.7 years at baseline. After a median follow-up time of 9.0 years, the prevalence of impaired activities of daily living (ADLs), instrumental activities of daily living (IADLs) and lower limb function (LEF) was 14.7%, 21.6%, and 50.3%, respectively. The values of four inflammatory biomarkers were used to calculate the state of inflammation composite score. Compared with the lowest quartile of the inflammation composite score, the highest quartile exhibited odds of impaired ADLs (OR = 1.589, 95% CI: 1.335–1.892), impaired IADLs (OR = 1.426, 95% CI: 1.228–1.657), and impaired LEF (OR = 1.728, 95% CI: 1.526–1.957). The association between systemic inflammation and functional limitations was partly mediated by cardiac and brain functions.
Conclusion
The present study showed that systemic inflammation in midlife was associated with a higher risk of late-life functional limitations. Protecting vital organ functions in midlife may reduce the risk of future functional limitations.
Trial registration: www.clinicaltrials.gov; Unique identifier: NCT00005131.