bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collateral benefits: River flow normalization for endangered fish enabled riparian rejuvenation
Authors: Rood Stewart B. , Hoffman Gregory C. , Merz Norm , Anders Paul , Benjankar Rohan , Burke Michael , Egger Gregory , Polzin Mary Louise , Soults Scott 
Published: February 2024

AbstractLike most rivers worldwide, the transboundary North American Kootenay/i River has experienced multiple impacts including watershed developments, river channelization, and floodplain clearing, draining, and diking. Construction of Libby Dam was authorized by the 1964 Columbia River Treaty (CRT) between the United States and Canada, and in 1975 began regulating downstream flows for flood risk management and hydropower generation. Following cumulative impacts, the endemic Kootenai River White Sturgeon population collapsed and was designated as endangered in 1994 (U.S. Endangered Species Act). Subsequent Biological Opinions from the U.S. Fish and Wildlife Service prescribed Libby Dam operations to provide springtime flow pulses for sturgeon spawning. These provided the unanticipated benefit of substantial seedling recruitment of native and introduced riparian cottonwoods and willows. The regulated flow regime was further adaptively managed to provide a more normative (natural) regime, to balance ecological functions with flood risk management and hydropower generation. The broadened ecological considerations would be consistent with the proposed priorities for the modernization of the international CRT. The observed responses revealed that (1) diverse aquatic and riparian organisms are dependent on common river flow characteristics; (2) a normalized flow regime provided substantial ecological benefits; and (3) due to multiple influences, hybrid ecosystems develop along regulated rivers, with a blending of natural and altered processes and communities. For other regulated rivers, we recommend that (1) high springtime flows be allowed, as feasible; (2) followed by the gradual post‐peak recession; and (3) the maintenance of sufficient flows through the warm and dry interval of mid to late summer.
Synthesis of a new photosensitizer for ablation of Uppsala 87 Malignant Glioma cells
Authors: Liu Yixian , Bao Xiaowen , Li Jiaqi , Liang Guangshu , Chen Yajun , Yan Linping 
Published: February 2024

AbstractPhotodynamic therapy (PDT) is a promising therapeutic modality for cancer treatment. Herein, we reported the synthesis of a newly synthesized photosensitizer (PS), BTR, for photoablation of Uppsala 87 Malignant Glioma (U87MG) cells. BTR nanoparticles (NPs) were prepared by co‐encapsulation with DSPE‐PEG‐2000. The results showed that BTR NPs possess extremely low dark toxicity after cellular uptake. To the opposite, significant phototoxicity of such NPs was observed with the help of a laser, leading to apparent cell apoptosis on U87MG cells. The results indicate that BTR NPs with excellent phototoxicity and low dark toxicity have some potential for photodynamic therapy against cancer cells.
Electronic Modulation in Cu Doped NiCo LDH/NiCo Heterostructure for Highly Efficient Overall Water Splitting
Authors: Xia Xuewen , Wang Shujuan , Liu Dan , Wang Fei , Zhang Xueqiang , Zhang Hao , Yu Xing , Pang Zhongya , Li Guangshi , Chen Chaoyi , Zhao Yufeng , Ji Li , Xu Qian , Zou Xingli , Lu Xionggang 
Published: February 2024

AbstractLayered double hydroxides (LDHs), promising bifunctional electrocatalysts for overall water splitting, are hindered by their poor conductivity and sluggish electrochemical reaction kinetics. Herein, a hierarchical Cu‐doped NiCo LDH/NiCo alloy heterostructure with rich oxygen vacancies by electronic modulation is tactfully designed. It extraordinarily effectively drives both the oxygen evolution reaction (151 mV@10 mA cm−2) and the hydrogen evolution reaction (73 mV@10 mA cm−2) in an alkaline medium. As bifunctional electrodes for overall water splitting, a low cell voltage of 1.51 V at 10 mA cm−2 and remarkable long‐term stability for 100 h are achieved. The experimental and theoretical results reveal that Cu doping and NiCo alloy recombination can improve the conductivity and reaction kinetics of NiCo LDH with surface charge redistribution and reduced Gibbs free energy barriers. This work provides a new inspiration for further design and construction of nonprecious metal‐based bifunctional electrocatalysts based on electronic structure modulation strategies.
Model‐based analysis and specification of functional requirements and tests for complex automotive systems
Authors: Wiecher Carsten , Mandel Constantin , Günther Matthias , Fischbach Jannik , Greenyer Joel , Greinert Matthias , Wolff Carsten , Dumitrescu Roman , Mendez Daniel , Albers Albert 
Published: February 2024

AbstractThe specification of requirements and tests are crucial activities in automotive development projects. However, due to the increasing complexity of automotive systems, practitioners fail to specify requirements and tests for distributed and evolving systems with complex interactions when following traditional development processes. To address this research gap, we propose a technique that starts with the early identification of validation concerns from a stakeholder perspective, which we use to systematically design tests that drive a scenario‐based modeling and analysis of system requirements. To ensure complete and consistent requirements and test specifications in a form that is required in automotive development projects, we develop a Model‐Based Systems Engineering (MBSE) methodology. This methodology supports system architects and test designers in the collaborative application of our technique and in maintaining a central system model, in order to automatically derive the required specifications. We evaluate our methodology by applying it at KOSTAL (Tier1 supplier) and within student projects as part of the masters program Embedded Systems Engineering. Our study corroborates that our methodology is applicable and improves existing requirements and test specification processes by supporting the integrated and stakeholder‐focused modeling of product and validation systems, where the early definition of stakeholder and validation concerns fosters a problem‐oriented, iterative and test‐driven requirements modeling.
Membrane Transport, Molecular Machines, and Maxwell's Demon
Authors: Borsley Stefan 
Published: February 2024

AbstractThe spontaneous generation of transmembrane gradients is an important fundamental research goal for artificial nanotechnology. The active transport processes that give rise to such gradients directly mirror the famous Maxwell's Demon thought experiment, where a Demon partitions particles between two chambers to generate a nonequilibrium state. Despite these similarities, discussion of Maxwell's Demon is absent in the literature on artificial membrane transport. By contrast, the emergence of rational design principles for nonequilibrium artificial molecular motors can trace its intellectual roots directly to this famous thought experiment. This perspective highlights the links between Maxwell's Demon and nonequilibrium machines, and argues that understanding the implications of this 19th century thought experiment is crucial to the future development of transmembrane active transport processes.
Factors associated with attitudes toward research MRI in older Asian Americans
Authors: Kota Karthik J , Dawson Alice , Papas Julia , Sotelo Victor , Su Guibin , Li Mei‐Ling , Lee Woowon , Estervil Jaunis , Marquez Melissa , Sarkar Shromona , Lopez Lisa Lanza , Hu William T. 
Published: February 2024

AbstractINTRODUCTIONSouth Asian (SA) and East Asian (EA) older adults represent the fastest‐growing racial/ethnic groups of Americans at risk for dementia. While recruiting older SA adults into a brain health study, we encountered unexpected hesitancy toward structural brain magnetic resonance imaging (MRI) analysis and stigmatizing attitudes related to internal locus of control (LoC) for future dementia risks. We hypothesized that support for MRI‐related research was influenced by these attitudes as well as personal MRI experience, perceived MRI safety, and concerns for personal risk for future dementia/stroke.METHODSWe developed a brief cross‐sectional survey to assess older adults’ MRI experiences and perceptions, desire to learn of six incidental findings of increasing impact on health, and attitudes related to dementia (including LoC) and research participation. We recruited a convenience sample of 256 respondents (74% reporting as 50+) from the New Jersey/New York City area to complete the survey (offered in English, Chinese, Korean, and Spanish) and modeled the proportional odds (PO) for favorable attitudes toward research activities.RESULTSSeventy‐seven SA and 84 EA respondents were analyzed alongside 95 White, Black, or Hispanic adults. White (PO = 2.54, p = 0.013) and EA (PO = 2.14, p = 0.019) respondents were both more likely than SA respondents to endorse healthy volunteers’ participation in research, and the difference between White and SA respondents was mediated by the latter's greater internal LoC for dementia risks. EA respondents had more worries for future dementia/stroke than SA respondents (p = 0.006) but still shared SA respondents’ lower wish (measured by proportion of total) to learn of incidental MRI findings.DISCUSSIONSA—and EA compared to SA—older adults had low desire to learn of incidental MRI findings but had different attitudes toward future dementia/stroke risks. A culturally appropriate protocol to disclose incidental MRI findings may improve SA and EA participation in brain health research.Highlights
Older Asian Americans have limited interest in incidental findings on research MRI
South Asians are most likely to attribute dementia to people's own behaviors
South Asians’ attitudes mediate lower support for healthy volunteers in research
South and East Asians differ in dementia worries and research‐related attitudes
Maximizing wind farm power output with the helix approach: Experimental validation and wake analysis using tomographic particle image velocimetry
Authors: van der Hoek Daan , den Abbeele Bert Van , Simao Ferreira Carlos , van Wingerden Jan‐Willem 
Published: February 2024

AbstractWind farm control can play a key role in reducing the negative impact of wakes on wind turbine power production. The helix approach is a recent innovation in the field of wind farm control, which employs individual blade pitch control to induce a helical velocity profile in a wind turbine wake. This forced meandering of the wake has turned out to be very effective for the recovery of the wake, increasing the power output of downstream turbines by a significant amount. This paper presents a wind tunnel study with two scaled wind turbine models of which the upstream turbine is operated with the helix approach. We used tomographic particle image velocimetry to study the dynamic behavior of the wake under the influence of the helix excitation. The measured flow fields confirm the wake recovery capabilities of the helix approach compared with normal operation. Additional emphasis is put on the effect of the helix approach on the breakdown of blade tip vortices, a process that plays an important role in re‐energizing the wake. Measurements indicate that the breakdown of tip vortices and the resulting destabilization of the wake are enhanced significantly with the helix approach. Finally, turbine measurements show that the helix approach was able to increase the combined power for this particular two‐turbine setup by as much as 15%.
Cosmological Einstein-$$\lambda $$-Perfect-Fluid Solutions with Asymptotic Dust or Asymptotic Radiation Equations of State
Authors: Friedrich Helmut 
Published: February 2024

AbstractThis article introduces the notions of asymptotic dust and asymptotic radiation equations of state. With these non-linear generalizations of the well known dust or (incoherent) radiation equations of state the perfect-fluid equations lose any conformal covariance or privilege. We analyse the conformal field equations induced with these equations of state. It is shown that the Einstein-$$\lambda $$
λ
-perfect-fluid equations with an asymptotic radiation equation of state allow for large sets of Cauchy data that develop into solutions which admit smooth conformal boundaries in the future and smooth extensions beyond. In the case of asymptotic dust equations of state sharp results on the future asymptotic behaviour are not available yet.
A simulation model to analyze the behavior of a faculty retirement plan: a case study in Mexico
Authors: Montufar-Benítez Marco Antonio , Mora-Vargas Jaime , Soto-Campos Carlos Arturo , Pérez-Lechuga Gilberto , Castro-Esparza José Raúl 
Published: February 2024

AbstractThe main goal in this study was to determine confidence intervals for average age, average seniority, and average money-savings, for faculty members in a university retirement system using a simulation model. The simulation—built-in Arena—considers age, seniority, and the probability of continuing in the institution as the main input random variables in the model. An annual interest rate of 7% and an average annual salary increase of 3% were considered. The scenario simulated consisted of the teacher and the university making contributions, the faculty 5% of his salary, and the university 5% of the teacher’s salary. Since the base salaries with which teachers join to university are variable, we considered a monthly salary of MXN 23 181.2, corresponding to full-time teachers with middle salaries. The results obtained by a simulation of 30 replicates showed that the confidence intervals for the average age at retirement were (55.0, 55.2) years, for the average seniority (22.1, 22.3) years, and for the average savings amount (329 795.2, 341 287.0) MXN. Moreover, the risk that a retiree of 62 years of age and more of 25 years of work, is alive after his savings runs out is approximately 98% and this happens at 64 years of age.
Valorization of waste paper sludge as a sustainable source for packaging applications
Authors: Quintana Elisabet , Valls Cristina , Roncero M. Blanca 
Published: February 2024

AbstractPaper sludge consists mainly of wet short cellulose fibers that are lost during papermaking and of residual chemicals used in the manufacturing process that remain dissolved in the water. Each ton of paper generates about 40–50 kg of dry sludge, of which 70% is primary sludge. Paper production, which exceeded 400 million tons globally in 2020, generates vast volumes of solid waste. Primary sludge is usually fiber-rich and hence suitable to be recycled back into the papermaking process. However, if the sludge is to be disposed of in landfills, sustainable practices must be developed in order to recover the fibers as they are valuable source for manufacturing high value-added products. This study investigates the valorization of paper sludge discarded by a filter paper manufacturer, with the purpose of producing cellulose acetate films for food packaging. The process involves recovering cellulose fibers from the sludge, purifying them and through acetylation reaction produce cellulose acetate films. FTIR spectra confirmed successful acetylation of fibers and also that acetyl groups reduced the hydrophilicity of cellulose—the contact angle was increased to over 80° from 50° in native cellulose. The films exhibited very good water barrier properties at both 50% and 90% relative humidity (RH).
Graphical abstract
Overexpression of aquaporin-1 plays a vital role in proliferation, apoptosis, and pyroptosis of Wilms’ tumor cells
Authors: Liu Hong , Jin Chen , Xia Nan , Dong Qian 
Published: February 2024

Abstract
Background
Nephroblastoma, also known as Wilms’ tumor (WT), is an embryonic malignant tumor and one of the most common malignant tumors in the abdominal region of children. The exact role and underlying mechanisms of aquaporin-1 (AQP1) in the occurrence and development of nephroblastoma remain unclear.

Methods
After overexpression of AQP1, cell proliferation was assessed using the CCK-8 proliferation assay and EdU staining. Flow cytometry was employed to assess cell apoptosis, and Western blotting (WB) analysis was conducted to validate the expression of relevant protein markers. mRNA sequencing (mRNA-Seq) was performed on WT cells overexpressing AQP1 to predict and characterize the associated mechanisms. Transmission electron microscopy was utilized to observe changes in the ultrastructure of WT cells undergoing apoptosis and pyroptosis following AQP1 overexpression. Functional in vivo validation was conducted through animal experiments.

Results
We validated that overexpression of AQP1 inhibited cell proliferation and promoted cell apoptosis and pyroptosis both in vitro and in vivo. mRNA-Seq analysis of WT cells with AQP1 overexpression suggested that these effects might be mediated through the inhibition of the JAK-STAT signaling pathway. Additionally, we discovered that overexpression of AQP1 activated the classical pyroptosis signaling pathway dependent on caspase-1, thereby promoting pyroptosis in WT.

Conclusion
These findings highlight the important functional role of AQP1 in the pathobiology of nephroblastoma, providing novel insights into the development of this disease. Moreover, these results offer new perspectives on the potential therapeutic targeting of AQP1 as a treatment strategy for nephroblastoma.
Utilizing least squares variance component estimation to combine multi-GNSS clock offsets
Authors: Mansur Gustavo , Brack Andreas , Sakic Pierre , Männel Benjamin , Schuh Harald 
Published: February 2024

AbstractThe International GNSS Service (IGS) provides combined satellite and station clock products, which are generated from the individual clock solutions produced by the analysis centers (ACs). Combinations for GPS and GLONASS are currently available, but there is still a lack of combined products for the new constellations such as Galileo, BeiDou, and QZSS. This study presents a combination framework based on least squares variance component estimation using the ACs’ aligned clock solutions. We present the various alignments required to harmonize the solutions from the ACs, namely the radial correction derived from the differences of the associated orbits, the alignment of the AC clocks to compensate for different reference clocks within each AC solution, and the inter-system bias (ISB) alignment to correct for different AC ISB definitions when multiple constellations are used. The combination scheme is tested with IGS MGEX and repro3 products. The RMS computed between the combined product and the aligned ACs’ solutions differ for each constellation, where the lowest values are obtained for Galileo and GPS with on average below 45 psec (13 mm) and reaching more than 150 psec (45 mm) for QZSS. The same behavior is repeated when the process is performed with the repro3 products. A clock and orbit combination validation is done using precise point positioning (PPP) that shows ionosphere-free phase residuals below 10 mm for all constellations, comparable with the AC solutions that are in the same level.
Code is law: how COMPAS affects the way the judiciary handles the risk of recidivism
Authors: Engel Christoph , Linhardt Lorenz , Schubert Marcel 
Published: February 2024

AbstractJudges in multiple US states, such as New York, Pennsylvania, Wisconsin, California, and Florida, receive a prediction of defendants’ recidivism risk, generated by the COMPAS algorithm. If judges act on these predictions, they implicitly delegate normative decisions to proprietary software, even beyond the previously documented race and age biases. Using the ProPublica dataset, we demonstrate that COMPAS predictions favor jailing over release. COMPAS is biased against defendants. We show that this bias can largely be removed. Our proposed correction increases overall accuracy, and attenuates anti-black and anti-young bias. However, it also slightly increases the risk that defendants are released who commit a new crime before tried. We argue that this normative decision should not be buried in the code. The tradeoff between the interests of innocent defendants and of future victims should not only be made transparent. The algorithm should be changed such that the legislator and the courts do make this choice.
Rules of the Game and Credibility of Implementation in the Control of Corruption
Authors: Meyer Karl Z. , Luiz John M. , Fedderke Johannes W. 
Published: February 2024

AbstractResearch suggests that institutions affect the levels of corruption in a country. We take these arguments a step further and examine whether it is the presence of inclusive institutions and/or the credible and consistent implementation of institutions that matter, as regards corruption. We use a novel approach to theoretically conceptualise and empirically operationalise institutions along two analytically distinct dimensions: the nature of the institutions (the de jure dimension), and the extent to which they are credibly and consistently implemented over time (the de facto dimension), using a panel dataset for 148 countries covering 2012 to 2018. We find that formal institutions are most effective in reducing corruption when the rules are credibly and consistently implemented. Furthermore, this effect appears to operate differently at different levels of national income. The nature of the formal institutions appears important across income levels, but particularly so at the upper middle income level, while the credible and consistent implementation of these institutions is primarily influential at upper middle income levels. We explain why this may be the case and elaborate on the policy implications.
Long-Term Effect of Having a Child at Risk of Developmental Delays on Parental Labor Force Participation
Authors: Hu Yanan , Callander Emily 
Published: February 2024

Abstract
Objective
This study aimed to examine the long-term influence of having a child at risk of different developmental delays (communication, mobility, self-care, relating, learning, coping, or behaving) on parental labor force participation as the child grows.

Method
A retrospective cohort was conducted using data from the Longitudinal Study of Australian Children survey, Waves 1–8 covering birth to 15 years of age of children. Multivariable logistic regressions were used to explore the odds ratio of mothers being out of the labor force at different children’s ages. Cox proportional hazards models were utilized to identify the ‘risk’ of mothers returning to the workforce after leaving. All models were adjusted for the mother’s age, education attainment, and employment status at time of birth, as well as marital status at the current wave.

Results
There were 5,107 records of children, and 266 of them were at risk of any developmental delays at age 4–5 years. This sample represents 243, 026 children born in Australia in 2003/04. After adjusting for potential confounders, mothers of children at risk of each type of developmental delay (except mobility and self-care) had greater odds of being out of, and not returning to the labor force from children aged 2–3 to 14–15 years, when compared to mothers of children who are not at risk of developmental delays. Similar differences were found for fathers but were distinctly small and with narrower fluctuations, compared to mothers.

Conclusion
Policies and programs funded by the government are greatly needed to support the mothers of children at risk of developmental delays.