bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN E-MODUL KEARIFAN LOKAL BERBANTUAN APLIKASI FLIPPING BOOK PADA MATERI GETARAN, GELOMBANG DAN BUNYI DI SMP NEGERI 3 KABILA
Authors: Iman Septian Halim , Yusuf Muhammad , Abdjul Tirtawaty , Odja Abdul Haris 
Published: November 2023

ABSTRAKTujuan penelitian ini adalah untuk mendeskripsikan validitas, kepraktisan, dan kevalidan E-Modul Kearifan Lokal berbantuan Aplikasi Flipping Book pada Materi Getaran, Gelombang dan Bunyi. Hasil penelitian menunjukkan bahwa (1) hasil validasi E-Modul Kearifan Lokal berbantuan Aplikasi Flipping Book oleh 2 (dua) validator memperoleh nilai rata-rata validasi 3,74 dan berada pada kategori valid dan bisa digunakan; (2) Aspek kepraktisan menunjukkan bahwa observasi keterlaksanaan pembelajaran memperoleh rata-rata persentase 92,73% dengan kriteria sangat baik. Respon peserta didik memperoleh rata-rata persentase yaitu 98,14% dengan kriteria sangat baik. Hasil yang diperoleh tersebut menunjukkan bahwa E-Modul yang dikembangkan praktis; dan (3) Aspek keefektifan menunjukkan bahwa observasi aktivitas peserta didik memperoleh rata-rata persentase pada uji coba 87,58% dengan kriteria sangat baik. Hasil yang diperoleh tersebut menunjukkan bahwa E-Modul yang dikembangkan efektif. Kata kunci: e-modul; kearifan lokal; flipping book; validitas; kepraktisan; keefektifan ABSTRACTThe purpose of this study was to describe the validity, practicality, and validity of the Local Wisdom E-Module assisted by the Flipping Book Application on Vibration, Waves and Sound Material. The results showed that (1) the validation results of the Local Wisdom E-Module assisted by the Flipping Book Application by 2 (two) validators obtained an average validation value of 3.74 and were in the valid and usable category; (2) The practicality aspect shows that the observation of the implementation of learning obtains an average percentage of 92,73% with very good criteria. Student responses obtained an average percentage of 98,14% with very good criteria. The results obtained show that the developed E-Module is practical; and (3) The aspect of effectiveness shows that the observation of students' activities obtains an average percentage in the tryout of 87,58% with very good criteria. The results obtained indicate that the developed E-Module is effective. Keywords: e-module; local wisdom; flipping book; validity; practicality; effectiveness.
PENGEMBANGAN PERANGKAT PEMBELAJARAN BERBASIS INKUIRI TERBIMBING UNTUK MENINGKATKAN KEMAMPUAN KOGNITIF PADA MATERI PESAWAT SEDERHANA
Authors: Demanto Fingki Aritsya , Latjompoh Masra , Yusuf Muhammad , Pikoli Masrid , Lamangantjo Chairunnisah J. , Abdjul Tirtawaty 
Published: November 2023

ABSTRAKPenelitian ini bertujuan mendeskripsikan perangkat pembelajaran IPA SMP yang valid, praktis dan efektif menggunakan model Inkuiri Terbimbing pada materi pesawat sederhana. Penelitian ini merupakan jenis penelitian pengembangan (research and development). Penelitian dilaksanakan di kelas VIII SMP Muhammadiyah 3 Kota Gorontalo semester ganjil tahun ajaran 2023/2024. Hasil penelitian diperoleh bahwa 1) perangkat yang dikembangkan valid berdasarkan lembar validasi dengan rata-rata 3,65. 2) Perangkat pembelajaran yang dikembangkan praktis berdasarkan keterlaksanaan pembelajaran sangat baik dengan rata-rata 97,5% dan respon peserta didik mencapai 96% dengan kategori sangat baik. 3) Perangkat pembelajaran yang dikembangkan efektif berdasarkan aktivitas siswa mencapai 74% dengan kriteria baik dan rata-rata persentase hasil belajar kognitif siswa sebesar 63,20% dengan kategori tinggi. Berdasarkan hasil penelitian disimpulkan bahwa perangkat pembelajaran IPA menggunakan model pembelajaran Inkuiri Terbimbing dapat meningkatkan kemampuan kognitif siswa pada materi pesawat sederhana dan layak digunakan dalam proses pembelajaran. Kata kunci : inkuiri terbimbing; IPA; perangkat pembelajaran. This research aims to describe valid, practical and effective junior high school science learning tools using the Guided Inquiry model on simple plane material. This research is a type of research and development. The research was carried out in class VIII of Muhammadiyah 3 Middle School, Gorontalo City, odd semester of the 2023/2024 academic year. The research results showed that 1) the device developed was valid based on the validation sheet with an average of 3,65. 2) The learning tools developed are practical based on very good learning implementation with an average of 97.5% and student responses reaching 96% in the very good category. 3) The learning tools developed were effective based on student activities reaching 74% with good criteria and the average percentage of students' cognitive learning outcomes was 63.20% in the high category. Based on the research results, it was concluded that the science learning tool used the Guided Inquiry learning model to improve students' cognitive abilities in simple plane material and was suitable for use in the learning process in simple. Keywords: guided inquiry; IPA; learning tools.
EFEKTIVITAS PEMBELAJARAN DENGAN ASSESMEN BERBASIS KAHOOT TERHADAP MOTIVASI BELAJAR FISIKA PESERTA DIDIK
Authors: Sindi Sindi , Nurlina Nurlina , Marisda, S.Pd., M.Pd Dewi Hikmah 
Published: November 2023

ABSTRAKFokus permasalahan dalam penelitian ini adalah rendahnya motivasi belajar peserta didik dalam pembelajaran fisika. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode pra-experimen. Desain penelitian adalah one group design pre-test post-test. Rumusan masalah penelitian ini adalah 1) Seberapa besar motivasi belajar fisika peserta didik sebelum diterapkan asesmen berbasis Kahoot?; 2) Seberapa besar motivasi belajar fisika peserta didik setelah diterapkan asesmen berbasis Kahoot?; 3) Seberapa besar peningkatan motivasi belajar fisika peserta didik sebelum dan sesudah diterapkan asesmen berbasis Kahoot?. Populasi penelitian ini adalah peserta didik kelas X MIA SMA Negeri 4 Takalar. Sampel penelitian ini terdiri dari 32 peserta didik kelas X MIA 2 di SMA Negeri 4 Takalar. Hasil penelitian menunjukkan data pretest motivasi belajar fisika peserta didik yaitu dengan nilai rata-rata sebesar 102,13 berada pada kategori sedang. Sedangkan hasil data post-test yang diperoleh yaitu sebesar 126,50 berada pada kategori sangat tinggi. Hasil uji N-gain score menunjukkan nilai sebesar 0,5 berada pada kategori sedang. Hal ini menunjukkan bahwa penggunaan asesmen berbasis kahoot efektif dalam meningkatkan motivasi belajar fisika peserta didik. Hasil penelitian ini diharapkan dapat menjadi salah satu inovasi dalam pembelajaran fisika sehingga peserta didik tidak mudah bosan dan jauh lebih aktif dalam pembelajaran. Kata kunci: asesmen; kahoot; motivasi belajar. ABSTRACTThe focus of the problem in this research is the low learning motivation of students in learning physics. This research is quantitative research using pre-experimental methods. The research design is a group design pre-test and post-test. The formulation of the research problem is 1) How big is the student's motivation to learn physics before implementing the Kahoot-based assessment?; 2) How big is the student's motivation to learn physics after implementing the Kahoot-based assessment?; 3) How big is the increase in students' motivation to learn physics before and after implementing the Kahoot-based assessment? The population of this study was class X MIA students at SMA Negeri 4 Takalar. The sample for this research consisted of 32 students from class X MIA 2 at SMA Negeri 4 Takalar. The research results show that the pretest data on students' physics learning motivation has an average score of 102.13, which is in the medium category. Meanwhile, the results of the post-test data obtained were 126.50, which is in the very high category. The N-gain score test results show a value of 0.5 which is in the medium category. This shows that the use of Kahoot-based assessment is effective in increasing students' motivation to learn physics. It is hoped that the results of this research can become an innovation in physics learning so that students do not get bored easily and are much more active in learning. Keywords: assessment; kahoot; learning motivation.
Proteção de direitos humanos e democracia: uma análise longitudinal da percepção do cidadão brasileiro de 2007 a 2015
Authors: Linhares Bianca de Freitas , Cabrera Valéria Cabreira 
Published: November 2023

Este artigo analisa a percepção longitudinal sobre a proteção de direitos humanos no Brasil e examina se essa compreensão esteve associada à percepção sobre democracia. A operacionalização da pesquisa deu-se pela metodologia quantitativa e pelo método estatístico, com o uso de dados de opinião pública coletados pelo Instituto Latinobarómetro no Brasil nas rodadas de pesquisa de 2007, 2008, 2009, 2011 e 2015. Encontrou-se que o cidadão brasileiro vem percebendo majoritariamente de forma negativa a proteção de direitos humanos ao longo do tempo. Além disso, no período analisado, essa percepção apareceu associada mais frequentemente com a satisfação com o funcionamento da democracia do que com a preferência pela democracia como forma de governo. Nesse sentido, a percepção da proteção de direitos humanos esteve associada mais frequentemente à percepção em nível de qualidade da democracia, do que em nível de apoio difuso ao regime político.
“Compartilhareis as fakes e as fakes me elegerão”: uma análise de fakes news anti-Haddad em redes sociais de católicos carismáticos
Authors: Silva Emanuel 
Published: November 2023

O presente artigo apresenta uma análise de imagens compartilhadas em redes sociais de grupos ligados à Renovação Carismática Católica (RCC), durante o pleito de 2018, que disseminaram fake news em relação à candidatura de Fernando Haddad (PT) à Presidência da República. Partindo da contextualização da disputa, analisa-se os marcadores religiosos presentes na semântica da disputa ênfase ao caráter marcadamente religioso no qual a disputa, destacando o apoio explícito de lideranças religiosas ao candidato do PSL, Jair Bolsonaro, sejam elas evangélicas ou católicas carismáticas, compreendendo tais marcadores a partir dos desdobramentos recentes da participação mais efetiva de atores do campo religioso na política, sobretudo em disputas eleitorais. O trabalho analisa o conteúdo e a de elementos imagéticos compartilhados em redes sociais (facebook sobretudo) que mobilizaram uma “antimilitância religiosa” contra a candidatura petista (o que exigiu uma análise do “antipetismo” como traço fundamental da disputa), por meio de imagens fakes, inexistindo o cuidado com o apuro do conteúdo visualizado, mesmo quando este beirava o grotesco, exigindo uma compreensão do lugar da verdade em temporalidades digitais. Por meio de análise de conteúdo e de imagem, poder-se-á observar os principais elementos mobilizados a partir do imaginário cristão que balizaram o apoio de católicos carismáticos à Bolsonaro, problematizando-os à luz do slogan religioso escolhido pelo candidato para lema de sua campanha: “conhecereis a verdade e a verdade vos libertará”, retirado de um versículo bíblico.
Contratos de gestão como instrumento de governança pública: um estudo exploratório
Authors: Tonelotto Diego Pugliese , Crozatti Jaime , Righetto Patricia 
Published: November 2023

O presente artigo tem o objetivo de descrever e caracterizar contratos de gestão celebrados entre o estado de São Paulo e Organizações Sociais de Saúde (OSS), para a gestão de unidades hospitalares de alta complexidade da rede pública de atendimento, como instrumentos de governança pública. Para tanto, optou-se pela realização de um estudo exploratório de avaliação qualitativa, com o emprego de pesquisa documental e análise descritiva. A amostra escolhida foi composta por contratos de gestão e termos aditivos firmados entre o estado de São Paulo e três Organizações Sociais de Saúde, quais sejam: Associação Paulista para o Desenvolvimento da Medicina (SPDM), Fundação do ABC e Serviço Social da Construção Civil do Estado de São Paulo (SECONCI), para a gestão de hospitais estaduais de alta complexidade no período compreendido entre 2009 e 2017. A ampla experiência do estado de São Paulo o qualifica como lócus adequado para o estudo, tendo em vista seu nível de pioneirismo na adoção deste modelo de gestão do serviço público de saúde, implementado há mais de 20 anos. Os resultados mostraram que o conteúdo dos contratos foi alterado ao longo do tempo, com o acréscimo de indicadores para controle das metas de produção e de qualidade, orientações para o desenvolvimento de perspectiva mais humana para a prestação dos serviços e aumento da quantidade de atendimentos contratualizados. A caracterização como instrumento de governança pública dá-se pelo fato de tais contratos permitirem a acountability (responsabilização na prestação de contas) e serem expressão de transparência ativa, que são princípios da própria governança.
Case Report: The application of metagenomic next generation sequencing in diagnosing fungal malignant external otitis: a report of two cases
Authors: Wang Qi , Hu Rui , Zhu YiFan , Zhu WenQing , Jiang Hua 
Published: November 2023

BackgroundMost of malignant external otitis (MEO) cases reported in the literature are attributed to Pseudomonas aeruginosa. Fungal infections in MEO are also likely but extremely rare. And conventional microbiology tests is difficult to diagnose.Case descriptionTwo patients were diagnosed with Fungal malignant external otitis (FMEO) due to Aspergillus by metagenomic Next-Generation Sequencing (mNGS) and recovered after comprehensive treatment including operation and voriconazole. The antifungal treatment was delayed due to repeated cultures of secretions being negative and pathological examination showed granulation tissue proliferation with extensive neutrophil infiltration.ConclusionmNGS might be helpful for patients suspected with FMEO, especially when conventional microbiology tests were negative.
Overall avidity declines in TCR repertoires during latent CMV but not EBV infection
Authors: Couturaud Barbara , Doix Bastien , Carretero-Iglesia Laura , Allard Mathilde , Pradervand Sylvain , Hebeisen Michael , Rufer Nathalie 
Published: November 2023

IntroductionThe avidity of the T-cell receptor (TCR) for antigenic peptides presented by the MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet, whether the TCR-ligand avidity can drive the clonal evolution of virus antigen-specific CD8 T cells, and how this process is determined in latent Cytomegalovirus (CMV)- against Epstein-Barr virus (EBV)-mediated infection remains largely unknown.MethodsTo address these issues, we quantified monomeric TCR-pMHC dissociation rates on CMV- and EBV-specific individual TCRαβ clonotypes and polyclonal CD8 T cell populations in healthy donors over a follow-up time of 15-18 years. The parameters involved during the long-term persistence of virus-specific T cell clonotypes were further evaluated by gene expression profiling, phenotype and functional analyses.ResultsWithin CMV/pp65-specific T cell repertoires, a progressive contraction of clonotypes with high TCR-pMHC avidity and low CD8 binding dependency was observed, leading to an overall avidity decline during long-term antigen exposure. We identified a unique transcriptional signature preferentially expressed by high-avidity CMV/pp65-specific T cell clonotypes, including the inhibitory receptor LILRB1. Interestingly, T cell clonotypes of high-avidity showed higher LILRB1 expression than the low-avidity ones and LILRB1 blockade moderately increased T cell proliferation. Similar findings were made for CD8 T cell repertoires specific for the CMV/IE-1 epitope. There was a gradual in vivo loss of high-avidity T cells with time for both CMV specificities, corresponding to virus-specific CD8 T cells expressing enhanced LILRB1 levels. In sharp contrast, the EBV/BMFL1-specific T cell clonal composition and distribution, once established, displayed an exceptional stability, unrelated to TCR-pMHC binding avidity or LILRB1 expression.ConclusionsThese findings reveal an overall long-term avidity decline of CMV- but not EBV-specific T cell clonal repertoires, highlighting the differing role played by TCR-ligand avidity over the course of these two latent herpesvirus infections. Our data further suggest that the inhibitor receptor LILRB1 potentially restricts the clonal expansion of high-avidity CMV-specific T cell clonotypes during latent infection. We propose that the mechanisms regulating the long-term outcome of CMV- and EBV-specific memory CD8 T cell clonotypes in humans are distinct.
Formation of two-dimensional laser-induced periodic surface structures on titanium by GHz burst mode femtosecond laser pulses
Authors: Kawabata Shota , Bai Shi , Obata Kotaro , Ozasa Kazunari , Miyaji Godai , Sugioka Koji 
Published: November 2023

GHz burst mode femtosecond (fs) laser pulses, which consist of a series of pulse trains with ultra-fast intervals of several hundred picoseconds, have offered distinct features for material processing compared to conventional irradiation of laser pulses (single-pulse mode). We apply GHz burst mode processing to fabricate laser-induced periodic surface structures (LIPSS) on the material surfaces. In our previous work for silicon (Si), we have found that GHz burst mode can create unique two-dimensional (2D) LIPSS composed of both parallel and perpendicular to the laser polarization direction. We proposed that the formation of 2D-LIPSS is attributed to the synergetic contributions of electromagnetic and hydrodynamic mechanisms. To further investigate more detailed formation mechanisms and explore practical applications, we employ titanium (Ti), whose properties are significantly different from Si. We demonstrate that GHz burst mode fs laser pulses (central wavelength: 1,030 nm, intra-pulse width: 230 fs, intra-pulse repetition rate (an intra-pulse interval): 4.88 GHz (205 ps) and burst pulse repetition rate: 10 kHz) can also fabricate 2D-LIPSS on Ti surfaces. We attribute the dominant formation mechanism of 2D-LIPSS to the generation of hot spots with highly enhanced electric fields due to transient change of material properties during GHz burst pulse irradiation. Based on this speculation, properly tailoring the shapes of the burst pulse with an optimum intra-pulse number enables the creation of well-defined 2D-LIPSS. Furthermore, essentially homogeneous 2D-LIPSS can be formed in a large area by laser scanning of a focused fs laser beam with a stage scanning speed of 5 mm/s.
Congenital scrub typhus: a case report and literature review
Authors: Liang Pinghua , Su Zengling , Chen Min , Li Sitao 
Published: November 2023

BackgroundThis study aimed to analyze the clinical course of a newborn with congenital scrub typhus caused by vertical transmission and explore early diagnosis and treatment strategies. The clinical data of the neonate were retrospectively analyzed and the related literature was reviewed.Case presentationThe newborn was a full-term one, with a good Apgar score at birth. The neonate had apnea at 3 h of life, requiring NICU care and IV antibiotics (piperacillin) for suspected sepsis. An examination revealed hepatosplenomegaly. Blood tests revealed anemia and thrombocytopenia and a chest x-ray showed patchy inflammation. On the second day of life, he developed a fever. On the third day of life, he required mechanical ventilation because his condition worsened after he presented with dyspnea, hypotension, depressed sensorium, and other signs of sepsis. Importantly, the neonate's mother had a history of scrub typhus at 31+ weeks of gestation. While the blood culture result was still pending, high-throughput sequencing of blood and cerebrospinal fluid was performed. To address the suspected scrub typhus infection, oral azithromycin dry suspension was added to the treatment regimen. High-throughput sequencing results on the 5th day of life confirmed a significant presence of 16SrRNA sequences in the blood, suggesting an Orientia tsutsugamushi infection. The neonate steadily recovered and was discharged 16 days after hospitalization. The neonate was followed up for 9 months, and the outcome was favorable with normal growth and development.ConclusionsThis article reports a case of congenital Orientia tsutsugamushi infection, a rare condition caused by vertical transmission. Our review of the literature, combined with the presented case, brings the total number of documented congenital scrub typhus cases caused by vertical transmission to eight. Regrettably, one patient from this group unexpectedly died on the 10th day of hospitalization, resulting in a mortality rate of 12.5% (1/8). The special transmission mode and clinical manifestations of this disease will serve as an alert to doctors for timely diagnosis and treatment. Because of the non-specific clinical manifestations of congenital scrub typhus, limited understanding, low index of suspicion among clinicians, and a lack of diagnostic facilities, scrub typhus is seriously underdiagnosed in pregnant women, fetuses, and neonates.
Development and validation of a disulfidptosis-related scoring system to predict clinical outcome and immunotherapy response in acute myeloid leukemia by integrated analysis of single-cell and bulk RNA-sequencing
Authors: Zhong Fangmin , Jiang Junyao , Yao Fang-Yi , Liu Jing , Shuai Xu , Wang Xin-Lu , Huang Bo , Wang Xiaozhong 
Published: November 2023

Background: Disulfidptosis is a metabolically relevant mode of cell death, and its relationship with acute myeloid leukemia (AML) has not been clarified. In this study, disulfidptosis scores were computed to examine the potential biological mechanisms.Methods: Consensus clustering was applied to detect disulfidptosis-related molecular subtypes. The least absolute shrinkage and selection operator (LASSO) regression analysis was used to construct a DRG prognostic model.Results: DRGs are upregulated in AML and associated with poor prognosis. The higher the disulfidptosis activity score, the worse the clinical outcome for patients, accompanied by increased immune checkpoint expression and tumor marker pathway activity. The two molecular subtypes exhibited distinct prognoses and tumor microenvironment (TME) profiles. A prognostic risk score model was established using six DRGs, and the AML cohort was divided into high- and low-risk score groups. Patients in the high-risk group experienced significantly worse prognosis, which was validated in seven AML cohorts. Receiver Operating Characteristic (ROC) curve analysis indicated that the area under the curve values for risk score prediction of 1-, 3-, and 5-year survival were 0.779, 0.714, and 0.778, respectively. The nomogram, in conjunction with clinicopathological factors, further improved the accuracy of prognosis prediction. The high-risk score group exhibited a higher somatic mutation frequency, increased immune-related signaling pathway activity, and greater immune checkpoint expression, suggesting a certain degree of immunosuppression. Patients with advanced age and higher cytogenetic risk also had elevated risk scores. According to drug prediction and AML anti-PD-1 therapy cohort analysis, the low-risk score group displayed greater sensitivity to chemotherapy drugs like cytarabine and midostaurin, while the high-risk score group was more responsive to anti-PD-1 therapy. Finally, clinical samples were collected for sequencing analysis, confirming that the progression of myeloid leukemia was associated with a higher risk score and a negative disulfidptosis score, suggesting that the poor prognosis of AML may be associated with disulfidptosis resistance.Conclusion: In conclusion, a systematic analysis of DRGs can help to identify potential disulfidptosis-related mechanisms and provide effective new biomarkers for prognosis prediction, TME assessment, and the establishment of personalized treatment plans in AML.