bluuebunny/crossref_metadata_2025_split huggingface dataset:
Should hypervascular incidentalomas detected on per-interventional cone beam computed tomography during intra-arterial therapies for hepatocellular carcinoma impact the treatment plan in patients waiting for liver transplantation?
Authors: Derbel Haytham , Galletto Athena , Mulé Sébastien , Calderaro Julien , Zaarour Youssef , Saccenti Laetitia , Ghosn Mario , Reizine Edouard , Blain Maxime , Laurent Alexis , Brustia Raffaele , Leroy Vincent , Amaddeo Giuliana , Luciani Alain , Tacher Vania , Kobeiter Hicham 
Published: November 2023

Abstract

Background and objective Current guidelines do not indicate any comprehensive management of hepatic hypervascular incidentalomas (HVIs) discovered in hepatocellular carcinoma (HCC) patients during intra-arterial therapies (IAT). The objective of this study is to evaluate the prognostic value of HVIs detected on per-interventional cone beam computed tomography (CBCT) during IAT for HCC in patients waiting for liver transplantation (LT). Material and methods In this retrospective single-institutional study, all liver-transplanted HCC patients between January 2014 and December 2018 who received transarterial chemoembolization (TACE) or radioembolization (TARE) before LT were included. The number of ≥ 10 mm HCCs diagnosed on contrast-enhanced preinterventional imaging (PII) was compared to that detected on per-interventional CBCT with a nonparametric Wilcoxon test. The correlation between the presence of an HVI and histopathological criteria associated with poor prognosis (HPP) on liver explants was investigated using the chi-square test. Tumor recurrence (TR) and TR-related mortality were investigated using the chi-square test. Recurrence-free survival (RFS), TR-related survival (TRRS), and overall survival (OS) were assessed according to the presence of HVI using Kaplan‒Meier analysis. Results Among 63 included patients (average age: 59 ± 7 years, H/F = 50/13), 36 presented HVIs on per-interventional CBCT. The overall nodule detection rate of per-interventional CBCT was superior to that of PII (median at 3 [Q1:2, Q3:5] vs. 2 [Q1:1, Q3:3], respectively, p < 0.001). No significant correlation was shown between the presence of HVI and HPP (p = 0.34), TR (p = 0.095) and TR-related mortality (0.22). Kaplan‒Meier analysis did not show a significant impact of the presence of HVI on RFS (p = 0.07), TRRS (0.48), or OS (p = 0.14). Conclusion Detection of HVIs during IAT should not affect the IAT treatment plan in patients awaiting LT.
Light Weight Learning Algorithms for Profanity Detection
Authors: Khurdula Harsha Vardhan 
Published: November 2023

Abstract

Text classification, mainly in the realm of online interaction of people in general through text, plays a vital role in maintaining safety over any social platform. Especially, in this age where it is easy to go online and type without filter. This research focuses on a comparative study of two simple yet prominent classifiers - Logistic Regression (LR) and Naive Bayes - to classify provided text as either toxic or non toxic. This research identifies potential improvements through iterative training and data processing enhancements.
ChatGPT in Oral and Maxillofacial Radiology Education
Authors: Öztürk Hilal Peker , Avsever İsmail Hakan , Şenel Buğra , Ayran Şükran , Özgedik Hatice Seda , Baysal Nurten 
Published: November 2023

Abstract
Introduction
Artificial intelligence refers to the ability of computer systems or machines to perform cognitive functions and tasks that are similar to those of humans.
The aim of this study is to assess the knowledge and interpretative abilities of ChatGPT-versions by administering a dentomaxillofacial radiology exam, comparing its performance with that of dentistry-students in Türkiye, and questioning the effectiveness of different language options.
Methods
This study is a descriptive research comparing the data obtained by presenting the midterm exam questions, which were routinely administered to 4thyear dental students, to ChatGPT versions 3.5 and 4 in both Turkish and English.
Results
Firstly the 20 test questions were evaluated. The p-value was <0.05, there is a significant difference between the ChatGPT answer sheets. ChatGPT-4 in English demonstrated the highest performance.
Answer sheets of chatGPT-4 in Turkish and in English demonstrated the best performance with 5 correct answers in open-ended questions.
Based on the answers obtained from 89 students to 20 test questions, a class profile was created. ChatGPT answer sheets and class-profile were analyzed, the p-value was p<0.05. Class-profile ranked first as ChatGPT-4 in English.
It was found a significant difference between the answer-sheets of ChatGPT and the class-profile for open-ended questions(p<0.10). The most successful results were obtained from ChatGPT-4 in Turkish and English, as well as the class profile.
Conclusion
As a cautionary note to dental students, it is important to mention that ChatGPT's knowledge and perception in the field of oral and maxillofacial radiology are not yet sufficient, particularly for use in examinations.
MODELS: a novel six-step framework for developing an infectious disease model
Authors: Rui Jia , Li Kangguo , Wei Hongjie , Guo Xiaohao , Zhao Zeyu , Wang Yao , Song Wentao , Abudunaibi Buasiyamu , Chen Tianmu 
Published: November 2023

Abstract

During the COVID-19 pandemic, numerous modeling studies about COVID-19 have been published. While partial articles exhibit clever design and are noticeable, some also contain methodological errors. For beginners and primary health workers, grappling with the diverse content of these articles is challenging. Therefore, we develop a model framework (MODELS) that outlines the process and considerations for establishing a reliable epidemic model. Our work provides beginner guidance to researchers who are interested in epidemic models.
Edges are all you need: Potential of Medical Time Series Analysis with Graph Neural Networks.
Authors: Walke Daniel , Steinbach Daniel , Gibb Sebastian , Kaiser Thorsten , Saake Gunter , Ahrens Paul , Broneske David , Heyer Robert 
Published: November 2023

Abstract

Machine learning is a powerful tool to develop algorithms for clinical diagnosis. However, standard machine learning algorithms are not perfectly suited for clinical data since the data are interconnected and may contain time series. As shown for recommender systems and molecular property predictions graph neural networks (GNNs) may represent a powerful alternative. In this study, we evaluated the performance and time consumption of GNNs compared to state-of-the-art algorithms on the classification of sepsis from blood count data as well as the importance and slope of each feature for the final classification. GNNs on evaluated similarity-graphs achieved an AUROC of up to 0.8747 comparable to the performance of ensemble-based machine learning algorithms and a neural network. The exploitation of time series information with GNNs achieved a superior AUROC of up to 0.9565. Finally, we discovered that feature slope and importance highly differ between tree-based (e.g., XGBoost) and non-tree-based algorithms (e.g., GNN).
Nanoemulsion-based active packaging for food products
Authors: Prasad Jaishankar , Dixit Aishwarya , Sharma Sujata P. , Mwakosya Anjelina W. , Petkoska Anka T. , Upadhyay Ashutosh , Kumar Nishant 
Published: November 2023

Recently, there has been an increasing trend in the food and pharmaceutical industries towards using nanotechnological approaches to drug delivery and active packaging (edible coatings and films). In the food sector, nanoemulsions are the most promising technology for delivering active components and improving the barrier, mechanical, and biological properties of packaging to ensure the safety and quality of food products, as well as extend their shelf life.
For this review, we used several databases (Google Scholar, Science Direct, PubMed, Web of Science, Scopus, Research Gate, etc.) to collect information about nanoemulsions and their role in edible packaging.
We searched for articles published between 2015 and 2022 and described different scientific approaches to developing active packaging systems based on nanoemulsions, as well as their high-energy and low-energy synthesis methods. We also reviewed the uses of different types of essential oil-based nanoemulsions in the packaging of food products to prolong their shelf life and ensure safety. Non-migratory active packaging and active-release packaging systems were also discussed, as well as their advantages and disadvantages.
LIMD2 is the Signature of Cell Aging-immune/Inflammation in Acute
Myocardial Infarction
Authors: Tao Ping , Chen Xiaoming , Xu Lei , Chen Junteng , Nie Qinqi , Xu Mujuan , Feng Jianyi 
Published: November 2023

Background:
Acute myocardial infarction (AMI) is an age-dependent cardiovascular
disease in which cell aging, immunity, and inflammatory factors alter the course; however, cell
aging-immune/inflammation signatures in AMI have not been investigated.

Methods:
Based on the GEO database to obtain microRNA (miRNA) sequencing, mRNA sequencing
and single-cell sequencing data, and utilizing the Seurat package to identify AMI-associated
cellular subpopulations. Subsequently, differentially expressed miRNAs and mRNAs
were screened to establish a network of competing endogenous RNAs (ceRNAs). Senescence
and immunity scores were calculated by single sample gene set enrichment analysis (ssGSEA),
ESTIMATE and CIBERSORT algorithms, and the Hmisc package was used to screen for genes
with the highest correlation with senescence and immunity scores. Finally, protein-protein interaction
(PPI) and molecular docking analyses were performed to predict potential therapeutic
agents for the treatment of AMI.

Results:
Four cell types (Macrophage, Fibroblast, Endothelial cells, CD8 T cells) were identified
in AMI, and CD8 T cells exhibited the lowest cell aging activity. A ceRNA network of miRNAs-
mNRA interactions was established based on the overlapping genes in differentially expressed
miRNAs (DEmiRNAs) target genes and differentially expressed mRNAs (DEmRNAs).
Twenty-four marker genes of CD8 T cells were observed. LIMD2 was identified as cell aging-
immune/inflammation-related hub gene in AMI. This study also identified a potential therapeutic
network of DB03276-LIMD2-AMI, which showed excellent and stable binding status between
DB03276-LIMD2.

Conclusion:
This study identified LIMD2 as a cell aging-immune/inflammation-related hub
gene. The understanding of the pathogenesis and therapeutic mechanisms of AMI was enriched
by the ceRNA network and DB03276-LIMD2-LAMI therapeutic network.
Comparison of Initial Thoracic CT Images of COVID-19 Patients with
Non-Variant, Alpha, Delta, and Omicron Variants: A Retrospective Study
Authors: Altuntas Emrah , Ceyhan Bilgici Meltem , Elmalı Muzaffer , Onar Arda , Bas Orhan 
Published: November 2023

Background::
CT findings and Ground glass opacity (GGO) volumes may differ between
SARS CoV-2 non-variant, alpha, delta, and omicron variants.

Objective::
To compare the thoracic CT findings, GGO volumes, and GGOs’ lung uptake rates
among patients with COVID-19 variants.

Methods::
Thoracic CT images of 83 patients with non-variant, 78 patients with alpha variant, 93
patients with delta variant, and 73 patients with omicron variant having positive Real-Time Polymerase
Chain Reaction test results were analyzed retrospectively. GGO volumes and lung volumes
were calculated by using the Cavalieri Principle. Differences in CT findings, ground-glass
opacity volumes, and lung involvement rates between non-variant and variant groups were evaluated.

Results::
There were significant differences found in the incidence of GGOs (p < 0.001), air bronchogram
(p = 0.007), reticulation (p = 0.002) and subpleural lines, and linear opacities (p = 0.034)
between non-variant and variant groups. GGO uptake rates (ground glass opacity volumes × 100
÷ lung volume) were 8.88% in the non-variant, 4.83% in the alpha variant, 3.50% in the delta
variant, and 2.02% in the omicron variant. In estimating variant groups, it was determined that the
increase in the rate of GGOs in the right lung increased the probability of having an omicron
variant, whereas the presence of nodules decreased it. The possibility of the delta variant increased
with an increase in the rate of ground glass opacities in the left lung.

Conclusion::
Thoracic CT findings solely can be helpful in distinguishing COVID-19 variants. Decreased
frequency of uptake rates of GGOs suggested that the severity of COVID-19 disease was
gradually decreasing.
Left Ventricular Pressure Strain Loops for Evaluation of Myocardial Work in
Type 2 Diabetic Patients with Hypertension
Authors: Huang Mei-Feng , Yuan Xin-Chun , Zeng Xi , Zhang Zhe-Yuan , Xia Qing-Qing , Zhou Zhi-Yu 
Published: November 2023

Background::
Type 2 diabetes mellitus (T2DM) and hypertension (HT) are the two most common underlying diseases worldwide, and they often coexist. The
long-term existence of both may lead to left ventricular dysfunction. Therefore, evaluating the cardiac function of T2DM patients with HT is vital
to guide treatment and improve prognosis. Left ventricular pressure strain loops (LVPSL) combine left ventricular strain and afterload, which can
quantify left ventricular energy expenditure and detect left ventricular subclinical systolic dysfunction. Many studies have focused on myocardial
work (MW) in uncomplicated T2DM patients or simple HT patients, but a few have focused on T2DM patients with HT.

Objective::
The study aimed to evaluate the MW changes in T2DM patients with HT using LVPSL and to find independent related factors of MW parameters.

Methods::
40 T2DM patients, 35 HT patients, 40 T2DM patients with HT (T2DM+HT group), and 35 controls were enrolled. The differences between
clinical data, conventional ultrasound parameters, and MW parameters were analyzed among the four groups.

Results::
The global longitudinal strain (GLS) of the T2DM group, HT group, and T2DM+HT group was lower than the control group (P<0.05). The global
work index (GWI) and global constructive work (GCW) in the T2DM group were lower than other groups (P<0.05). The GWI of the HT group
was higher than other groups (P<0.05), while GCW was only higher than the T2DM group and T2DM+HT group (P<0.05). The GWI and GCW of
the T2DM+HT group were higher than the T2DM group and were lower than the HT group(P<0.05), while there was no significant difference
with the control group. HT group and T2DM+HT group had higher global work waste (GWW) (P<0.05). The global work efficiency (GWE) of the
T2DM+HT group was lower than other groups (P<0.05). Systolic blood pressure (SBP) and glycosylated hemoglobin (HbA1c) were independent
factors of each MW parameter.

Conclusion::
LVPSL can recognize left ventricular subclinical systolic dysfunction early in patients with T2DM and HT. Compared to simple T2DM or HT, the
combination of T2DM and HT had greater damage to left ventricular systolic function. SBP and HbA1c are two factors that have a considerable
impact on MW parameters. The impact of afterload on MW parameters should be paid more attention to.
Clinical and Temporal Radiological Findings from Critical Patients with
COVID-19 Pneumonia: A Descriptive Study
Authors: Tian Ye , Wang Yuqiong , Liu Min , Huang Xu , Zhang Yi , Wu Xiaojing , Huang Linna , Cui Xiaoyang , Gu Sichao , Zhan Qingyuan 
Published: November 2023

Background:
In late December 2019, Wuhan, the capital of Hubei Province, China, became the center of an outbreak of pneumonia caused by severe acute
respiratory syndrome Coronavirus 2 (SARS-CoV-2).

Introduction:
The radiological changes in the lungs of critical people with coronavirus disease 2019 (COVID-19) pneumonia at different times have not been
fully characterized. We aim to describe the computed tomography findings of patients with critical COVID-19 pneumonia at different disease
stages.

Methods:
Clinical and laboratory features of critical patients were assessed. CT scans were assigned to groups 1, 2, 3, or 4 based on the interval from
symptom onset (within 2 weeks; ≥ 2-4 weeks; ≥ 4-6 weeks; or ≥ 6 weeks, respectively). Imaging features were analyzed and compared across the
four groups. Total CT scores, corresponding periods of laboratory findings, and glucocorticoid dosages during the imaging intervals were
longitudinally observed in five patients with complete data.

Results:
All 11 critical patients (median age: 60 years [42-69]) underwent a total of 40 CT examinations, and the acquisition times ranged from 1-59 days
after symptom onset. Median total CT scores were 18 (9-25.25); 44.5 (42.88-47.62); 43.75 (38.62-49.38); and 42 (32.25-53.25) in groups 1, 2, 3,
and 4, respectively. The observed lesions were mainly bilateral (37 [92.5%]). The median values of involved lung segments were 10.5 (4.5-13.5);
17 (16-18.5); 18 (18-19.5); and 18 (18-19) in groups 1-4, respectively. The predominant patterns of observed abnormalities were ground-glass
opacities (GGO) (9 [90%]); GGO with reticulation and mixed patterns (3 [37.5%] for both); GGO with consolidation (3 [30%]); and GGO with
reticulation (8 [66.7%]) in groups 1-4, respectively. Patients developed fibrotic manifestations at later stages.

Conclusion:
Critical patients with COVID-19 infection generally presented with temporally changing abnormal CT features from focal unilateral to diffuse
bilateral GGO and consolidation that progressed to or coexisted with reticulation in the long term after symptom onset. Low-dose glucocorticoids
may be effective in patients with interstitial changes on CT findings.
Efficacy of Bronchial Artery Embolization for Clinically Suspected Bronchial
Dieulafoy’s Disease
Authors: Cha Jung Guen , Hong Jihoon , Kim Gab Chul , Park Byunggeon , Park Jongmin , Park Seo Young , Shin Kyung Min , Lim Jae-Kwang , Lee So Mi 
Published: November 2023

Background::
The efficacy of bronchial artery embolization (BAE) for bronchial Dieulafoy’s disease (BDD) has not been well established.

Objective::
This study aimed to evaluate the safety and efficacy of BAE in patients with clinically suspected BDD presenting with major hemoptysis, and to
describe angiographic findings.

Methods::
17 patients (all men; mean age, 53.5 years) diagnosed with clinically suspected BDD by bronchoscopy (n = 7) or CT angiography (CTA) (n = 10)
and who underwent BAE after directional and segmental localization of the target bronchus were enrolled. BAE was performed at the culprit
bronchial artery traveling toward the target bronchus, regardless of the pathologic angiographic findings. Angiographic findings and clinical
outcomes of BAE, including technical and clinical success, complication, recurrent hemoptysis, and follow-up imaging, were retrospectively
reviewed.

Results::
Representative angiographic findings included parenchymal hypervascularity prominent in the lobe where the BDD was located (82.4%), bronchial
artery hypertrophy (70.6%), and contrast extravasation into the bleeding bronchus (17.6%). BAE was technically successful in all patients. All
hemoptysis ceased within 24 h. No procedure-related complications occurred. During a mean follow-up of 491.9 days, 1 (6%) patient experienced
recurrent hemoptysis. Follow-up bronchoscopy or CT performed in 10 (58.8%) patients showed the disappearance of pre-existing lesions (n = 9) or
glue cast within the target bronchial artery (n = 1).

Conclusion::
Bronchial angiography showed pathologic findings in most patients with clinically suspected BDD. BAE assisted by bronchoscopy or CTA
localization is a safe and effective treatment for patients with clinically suspected BDD with excellent short- to mid-term results.
Astatine-211 Radiopharmaceuticals; Status, Trends, and the Future
Authors: Rabiei Mobina , Asadi Mahboobeh , Yousefnia Hassan 
Published: November 2023

Abstract:
The low range of alpha particles provides an opportunity to better target cancer cells
theoretically leading to the introduction of interesting alpha emitter radiopharmaceuticals including
225Ac, 212Pb, etc. The combination of high energy and short range of alpha emitters differentiates
targeted radiotherapy from other methods and reduces unwanted cytotoxicity of the
cells around the tumoral tissue. Among interesting alpha emitters candidates for targeted therapy,
211At, one of the radioisotopes with the best optimal decay properties, shows great promise
for targeted radiotherapy in some animal prostate cancer xenograft studies and bone micro tumors
with significant effects compared to other beta and alpha emitters and also demonstrates
interesting properties for clinical applications. However, production and application of this alpha
emitter in the development of actinium-based radiopharmaceuticals is hampered by many
obstacles. This mini-review demonstrates 211At production methods, chemical separation, radiolabeling
procedures, 211At-radiopharmaceuticals and their clinical trials, transport, logistics, and
costs and future trends in the field for ultimate clinical applications. This review showed that
there are limited clinical trials on 211Ac-based radiopharmaceuticals, which is due to the low
accessibility of this radioisotope and other limitations. However, the development programs of
major industries indicate the development of 211Ac-based radiopharmaceuticals in the future.
A Review on Innovative Nanomaterials for Enhancing Energy
Performance of the Building Envelope
Authors: Ashraf Ali Nouran , Sadek Samir , Abdin Ahmed 
Published: November 2023

Abstract:
The greatest threat of the 21st century is global warming. The building sector is a major
contributor to energy consumption and greenhouse gas emissions. About 60% of the total energy
consumed in the buildings is caused by HVAC systems. Nanotechnology is an emerging technology
that can introduce innovative materials in the building sector which offers great potential for development
of innovative building products to enhance performance and energy efficiency of the building.
Nanomaterials are a promising candidate for building thermal insulation. This paper presents a
theoretical overview of twenty case-based scenarios on the application of nanomaterials to reduce
energy consumption in buildings. A comprehensive list of different nanomaterials is reviewed from
the literature, as non-structural, insulation, and thermal energy storage materials to improve the insulation
performance of the building. Extensive testing and simulation modelling have turned out to
be the most popular in this area of research methods for experimental and theoretical studies. The
combination of these methods can yield a reliable technique for studying nanomaterials. Finally,
embedding nanomaterials into building walls, floors, and roofs can reduce energy consumption and
enhance thermal performance of a building’s envelope.
Chế tạo graphene từ thanh graphite sử dụng phương pháp bóc tách điện hóa dựa vào kỹ thuật thế bậc thang
Authors: Phan Nguyễn Đức Dược , Trần Văn Hậu , Bùi Thúc Minh , Phan Nhật Nguyên , Nguyễn Thị Hương , Phan Văn Cường 
Published: November 2023

Trong nghiên cứu này, vật liệu graphene (GR) được chế tạo từ thanh graphite sử dụng phương pháp bóc tách điện hóa với các loại điện áp khác nhau đặt vào hai đầu điện cực, bao gồm các điện áp không đổi 6 V, 8 V, 10 V và kỹ thuật thế bậc thang hai giai đoạn từ 0-2 V và 2-10 V trong môi trường ammonium sulfate (NH4)2SO4. Kết quả chế tạo đã được khảo sát bằng các phép đo thế Zeta, kính hiển vi điện tử quét phát xạ trường (FE-SEM), kính hiển vi lực nguyên tử (AFM) và quang phổ Raman để xác định đặc trưng và cấu trúc của vật liệu GR. Thế Zeta thu được của GR-010 có giá trị -47,7 mV cho thấy hiệu quả phân tán trong môi trường nước, hiệu quả này do khả năng liên kết tốt với các ion âm ở bề mặt và biên của GR. Kết quả đo SEM và AFM cũng chỉ ra bề dày trung bình của các tấm GR-010 thu được vào cỡ 1,8 nm tương ứng 3-5 lớp GR, nhỏ hơn so với các mẫu GR-6, GR-8 và GR-10 tương ứng với các điện áp 6 V, 8 V và 10 V. Kết quả phân tích Raman cũng cho thấy mức độ sai hỏng của GR-010 thấp hơn so với GR-6, GR-8 và GR-10 với tỷ số ID/IG = 0,36.