bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of nadir PSA value and time to nadir PSA in patients with metastatic castration-naive prostate cancer receiving first-line hormonotherapy
Authors: İnci Bediz Kurt , Gürler Fatih , Sütcüoğlu Osman , Baştuğ Vural , Yazıcı Ozan , Üner Aytuğ , Özet Ahmet , Özdemir Nuriye 
Published: December 2023

ABSTRACT

Background:
The current study aimed to evaluate the effect of the time duration to reach the lowest prostate-specific antigen (PSA) from the onset of first-line hormonal treatment (time to nadir PSA, TTNpsa) on survival in castration-naive metastatic prostate cancer (CN-MPC) patients.

Methods:
Eighty patients who had PSA response >80% with first-line hormonal therapy (luteinizing hormone-releasing hormone, LH-RH analog +/- bicalutamide) were included in this study.

Results:
Under androgen deprivation therapy (ADT), a significant positive correlation was found between TTNpsa, nadir PSA (Npsa) duration, and progression-free survival (PFS) (p < 0.001) and overall survival (OS) (p < 0.001). There was no correlation between TTNpsa and Npsa duration. TTNpsa and Npsa durations were independently correlated with PFS and OS. In patients with TTNpsa value ≥19 weeks, the median PFS was 126 (95% CI, 68–184) weeks compared with TTNpsa <19-week group in which the median PFS was 44 (95% CI, 26–62) weeks (p = 0.033). In patients with TTNpsa value ≥19 weeks, the median OS was 242 (95% CI, 169–315) weeks compared with TTNpsa <19-week group in which the OS was 156 (95% CI, 89–223) weeks (p = 0.018). The median nadir PSA value was 1 ng/mL. The median PFS was significantly longer in the patient group with ≤1 ng/mL (137 weeks, 95% CI, 50–224) compared with the group with >1 ng/mL (41 weeks, 95% CI, 34–48) (p < 0.001). The median OS was significantly longer in the patient group with nadir PSA ≤1 ng/mL (296 weeks, 95% CI, 220–272) compared to the group with >1 ng/mL (131 weeks, 95% CI, 84–178) (p = 0.002). In patients with nadir PSA ≤1 ng/mL (n = 40), there was no relationship between TTNpsa and Npsa duration with both PFS and OS. However, in patients with nadir PSA >1 ng/mL (n = 40) subgroup, there was a significant positive correlation between TTNpsa and PFS, and OS (p < 0.001, P = 0.016, respectively).

Conclusion:
In CN-MPC who received first-line ADT, especially in the group with the nadir PSA value >1 ng/mL, the duration of TTNpsa was positively correlated with PFS and OS.
The clinical impacts of the prognostic nutritional index for the esophageal cancer patients who received curative treatment
Authors: Aoyama Toru , Atsumi Yosuke , Kawahara Shinnosuke , Tamagawa Hiroshi , Tamagawa Ayako , Maezawa Yukio , Kano Kazuki , Murakawa Masaaki , Kazama Keisuke , Numata Masakatsu , Oshima Takashi , Yukawa Norio , Masuda Munetaka , Rino Yasushi 
Published: December 2023

ABSTRACT

Background:
We investigated the impact of the prognostic nutritional index (PNI) on esophageal cancer survival and recurrence after curative treatment.

Methods:
This study included 120 patients who underwent curative surgery followed by the adjuvant treatment for esophageal cancer between 2008 and 2018. The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified.

Results:
The PNI of 49 was regarded to be the optimal critical point of classification considering the 1-year, 3-year, and 5-year survival rate. The OS rates at three and five years after surgery were 47.4% and 36.0% in the PNI low group, respectively, and 62.5% and 56.5% in the PNI high group, which amounted to a statistically significant difference (P = 0.020). The RFS rates at three and five years after surgery were 31.0% and 24.8% in the PNI low group, respectively, and 50.9% and 42.8% in the PNI high group, which amounted to a statistically significant difference (P = 0.020). A multivariate analysis demonstrated that the PNI was a significant independent risk factor for the OS and a marginally significant independent risk factor forRFS.

Conclusion:
The PNI was a risk factor for survival in patients who underwent curative treatment for esophageal cancer. It is necessary to develop the effective plan of the perioperative care and the surgical strategy according to the PNI.
Clinicopathological profile and survival analysis of esophageal carcinoma: A retrospective study in a tertiary care hospital in Northeast India
Authors: Baidya Kishalay , Devi Yumkhaibam Sobita , Rai Hari K. , Devi Ningthoujam D. , Sinam Neeta , Kilari Gowtham L. T. 
Published: December 2023

ABSTRACT

Background:
Esophageal cancer (EC) is an extremely aggressive tumor with one of the highest geographic, ethnic, and gender variations. Various factors including tobacco consumption, unhealthy diet, and socioeconomic status have been implicated in the etiology of EC. Despite the advent of modern treatments, the prognosis of EC is dismal. This study has been undertaken to review the clinical and pathologic profiles, treatment approach, and survival pattern in patients with EC in a tertiary care hospital in northeast India.

Materials and Methods:
A retrospective descriptive study was done with 179 EC patients presented to our department between January 2013 and December 2020. Statistical analysis was done by using IBM Statistical Package for the Social Sciences version 21. P- value <0.05 was considered significant.

Results:
The majority of the patients presented in the sixth decade of life from rural areas with male to female ratio of 3.7:1. Dysphagia was the most common presenting feature. High incidence of tobacco and alcohol use was found. Mid-esophagus is the most common site and squamous cell carcinoma is the most common type. Fifty-two (29.1%) and 71 (39.6%) patients presented in stages III and IV, respectively. Twenty-four (13.4%) patients presented with metastatic disease, the lung being the most common site. Patients were treated with surgery, chemotherapy, radiotherapy, or combination of any of these. Overall median survival for the EC patients was 6 months. Patients treated with concurrent chemoradiation had better survival.

Conclusion:
EC is a serious malignancy with a dismal prognosis due to the advanced stage at presentation. Larger clinical trials using new therapeutic strategies are the need of the hour.
Rate of propagation for the Fisher-KPP equation with nonlocal diffusion and free boundaries
Authors: Du Yihong , Ni Wenjie 
Published: December 2023

In this paper, we obtain sharp estimates for the rate of propagation of the Fisher-KPP equation with nonlocal diffusion and free boundaries. The nonlocal diffusion operator is given by

\int_{\R}J(x-y)u(t,y)\,dy-u(t,x)

, and our estimates hold for some typical classes of kernel functions

J(x)

. For example, if for

|x|\gg 1

the kernel function satisfies

J(x)\sim |x|^{-\gamma}

with

\gamma>1

, then it follows from [Y. Du et al., J. Math. Pures Appl. 154, 30–66 (2021)] that there is a finite spreading speed when

\gamma>2

, namely the free boundary

x=h(t)

satisfies

\lim_{t\to\infty}h(t)/t=c_{0}

for some uniquely determined positive constant

c_{0}

depending on

J

, and when

\gamma\in (1, 2]

,

\lim_{t\to\infty}h(t)/t=\infty

; the estimates in the current paper imply that, for

t\gg 1

,

c_{0}t-h(t)\sim
\begin{cases}1&\text{ when $\gamma>3$,}\\
\ln t&\text{ when }\gamma=3,\\
t^{3-\gamma}&\text{ when }\gamma\in (2, 3),\\
\end{cases}
\qquad
h(t)\sim
\begin{cases}
t\ln t&\text{ when }\gamma =2,\\
t^{1/(\gamma-1)}&\text{ when }\gamma\in (1,2).
\end{cases}

Our approach is based on subtle integral estimates and constructions of upper and lower solutions, which rely crucially on guessing correctly the order of growth of the term to be estimated. The techniques developed here lay the groundwork for extensions to more general situations.
Joint user plane function instance and base station scheduling in mobile networks
Authors: Jang Seokwon , Ko Namseok , Lee Jaewook , Kyung Yeunwoong , Ko Haneul 
Published: December 2023

AbstractTo guarantee a high data transmission rate in heterogeneous mobile networks, sufficient small base stations (SBSs) and user plane function (UPF) instances should be active. However, the excessive operation of SBSs and UPF instances can increase the operating expenditure (OPEX) for the network operator. To balance the data rate and OPEX, we propose a joint UPF instance–SBS scheduling algorithm (J‐UBSA). In the proposed J‐UBSA, a controller periodically determines the appropriate number of active SBSs and UPF instances based on estimated variations in session requests. The decision‐making process is formulated as a constrained Markov decision process and converted into a linear programming model to obtain the optimal solution using a traditional algorithm with low complexity. Evaluation results demonstrate that J‐UBSA can substantially reduce the OPEX while guaranteeing a suitable average data rate for mobile devices.
Influence of geomorphological conditions of a mountain region on the intensity of hazardous geological processes
Authors: Габараев А.Ф. , Мельков Д.А. , Кортиев А.Л. , Козырев Е.Н. 
Published: December 2023

Геморфология является одним из ключевых факторов развития геологических процессов. В связи со значительной массой смещаемого материала склоновые процессы, обладают огромной разрушительной силой и представляют большую опасность для жилых, транспортных и других объектов экономики. На примере рекреационного комплекса Мамисон исследовано влияние геоморфологических особенностей горного региона на интенсивность проявления опасных геологических процессов. Методы. В работе использован комплексный подход, включающий математические модели, численные эксперименты, регрессионный анализ натурных и численных данных и разработку комплексной методики в ГИС технологиях. На основе данных космического зондирования Земли SRTM была создана цифровая модель рельефа (DEM) и выполнены расчеты устойчивости склонов в статической постановке методом Бишопа и при динамических воздействиях. При этом динамические (сейсмические) колебания моделировались методом конечных элементов. Результаты.Установлена связь интенсивности колебаний поверхности скального массива с коэффициентом, равным произведению угла наклона рельефа на относителную высоту, и получены формулы для пиковых ускорений и приращений интенсивности. На основе полученных данных было выполнено ранжирование территории по комплексному влиянию статических и динамических нагрузок на массив.
Hemorphology is one of the key factors in the development of geological processes. Due to the significant mass of displaced material, slope processes have enormous destructive power and pose a great danger to accommodation, transport and other economic facilities. In example of the Mamison recreational complex, the influence of the geomorphological features of the mountain region on the intensity of the manifestation of hazardous heological processes was studied. Methods. The work uses an integrated approach, including mathematical models, numerical experiments, regression analysis of natural and numerical data and the development of an integrated methodology in GIS technologies. Based on SRTM Earth space sensing data, a digital elevation model (DEM) was created and slope stability calculations were performed in a static setting using the Bishop method and under dynamic loadings. In the latter case, seismic vibrations were modeled by the finite element method. Results.A connection has been established between the intensity of vibrations of the surface of a rock massif and a coefficient equal to the product of the angle of inclination of the relief and the relative height, and formulas for peak accelerations and intensity increments have been obtained. Based on the data obtained, the territory was ranked according to the complex influence of static and dynamic loads on the massif.
A study of risk factors for breast cancer in Al-Anbar province: a case- control study
Authors: Sarhan Yaseen , Bardan Raghda 
Published: December 2023

Background: Globally, breast cancer is a widespread malignancy among women, ranking as the second leading cause of female mortality. This study investigates risk factors for breast cancer in AL-Anbar province, Iraq, emphasizing their significance in disease development.
Methods: An investigation was carried out at Al-Anbar Cancer Center in Al-Anbar province, Iraq, employing a case-control design. The study comprised 60 confirmed breast cancer cases and 120 controls without breast issues. Data was collected through direct interviews using a semi-structured questionnaire, and subsequent analyses included descriptive, bivariate, and multivariate approaches.
Results: About 48.0% aged 41-49, and 25% aged 50-59. Case and control groups were matched in age, but varied in marital, education, occupation, menopausal status. Women with benign breast diseases have a 1.7 times higher breast cancer risk (OR=1.7, CI=0.063-4.53). Positive family history triples the risk (OR=3, CI=1.21-7.80, P=0.002), and the sedentary lifestyle exhibits 5 times higher risk of breast cancer (OR=5.67, CI=2.89-4.13, P < 0.001). Menstrual age, parity, and reproductive factors influence breast cancer risk. Menarche at ≤12 years triples the risk (OR=3.05, CI=1.82-5.05, P<0.001), while menarche at ≥16 decreases it (OR=0.89, CI=0.06-5.12, P<0.001). Nulliparity increases risk 2.1 times (OR=2.1, CI=0.8-4.89, P=0.002), and more live births provide significant protection. Preterm delivery before the eighth month triples the risk (OR=2.9, CI=1.32-6.53, P=0.002). Multiple children prevent breast cancer, while mother's age at first full birth ≥30 raises the risk 3.5 times (OR=3.4, CI=1.45-7.88, P=0.014). Women who never breastfed had a significant twofold higher risk of breast cancer (OR=2, CI=0.8-4.38, P=0.003). Postmenopausal women at ≥50 years faced a threefold higher risk than their counterparts (OR=3.25, CI=1-1.11, P=0.004). Hormonal use showed a marginal risk increase (OR=1.2, CI=0.5-1.8, P<0.001).
Conclusion: Breast cancer susceptibility arises from diverse factors like genetics, nutrition, environment, and lifestyle. Effectively managing and preventing breast cancer involves implementing strategic control measures.
XXIV Jornadas de Gestión de la Información “RE/CORDIS: construcción y recuperación de la memoria colectiva» (Madrid, 4 y 5 de octubre de 2023)
Authors: Álvaro Gómez Celia , López de la Fuente Elena , Manglano Bosch Victoria , Morales Sanabria Carmen , Santamaría Ramírez Luisa 
Published: December 2023

Resumen de las diferentes comunicaciones, talleres y actividades que se llevaron a cabo en las XXIV Jornadas de Gestión de la Información de la Sociedad Española de Documentación e Información Científica (SEDIC), celebradas en Madrid del 4 al 5 de octubre en la Biblioteca Nacional de España, en el Archivo Histórico Nacional y en las excavaciones arqueológicas de la calle Peironcely 6 y 8 (Madrid). Esta edición de las Jornadas se centró en la memoria colectiva desde diferentes perspectivas: su conceptualización, los aspectos técnicos y legales en proyectos de memoria colectiva y la presentación de proyectos concretos de esta temática. También se entregaron el XVII Premio Nacional SEDIC a la Calidad e Innovación "Carmen Rodríguez Guerrero", el VIII Premio al proyecto universitario más innovador en el ámbito de la gestión de la información y de la Documentación y el Diploma al socio de honor de SEDIC 2023.
CAIE- Centro de Apoyo a la Investigación Económica: un soporte en la producción y promoción a la investigación del Banco de la República (Colombia)
Authors: Garrido-Arenas Humbert-Alexander , Bahos-Olivera Angélica 
Published: December 2023

El Banco de la República produce al año en promedio 50 documentos de trabajo y 30 publicaciones indexadas, ocupando el primer lugar en el ranking de instituciones colombianas que genera el sitio REPEC, y la segunda posición en Colombia según el número de documentos indexados en Scopus en el área de Economía, luego de la Universidad de los Andes.
En el Banco, el Centro de Apoyo a la Investigación Económica (CAIE) es la unidad que acompaña gran parte de los procesos generación del conocimiento académico (creación, publicación, uso, acceso, divulgación y evaluación). Desde su creación en diciembre de 2013, el CAIE ha trazado diferentes planes de acción, robusteciendo su portafolio de servicios e implementado diferentes estrategias con el objetivo de contribuir a la accesibilidad y uso de los productos de conocimiento que genera la institución, a la vez que ha buscado posicionarla como un referente para la investigación económica en el país, y con un lugar destacado por su actividad académica entre los Bancos Centrales.
MENINGKATKAN KETERAMPILAN BERBICARA BAHASA INGGRIS SISWA MENGGUNAKAN MODEL PEMBELAJARAN RUNNING DICTATION
Authors: Adawiyah Wilda Nur Aeni , Mangkuwibawa Hilman , Rifqi Mahmud Muhammad 
Published: December 2023

This research aims to improve students' speaking skills using the Running Dictation learning model. This research was motivated by problems that had been discovered from the results of a preliminary study in the learning process when students spoke English. That the students' speaking skills do not meet the KKM set by the school, namely 75. The research method used is classroom action research (PTK) with three cycles in which each cycle contains two actions. The subjects of this research were 25 class VI students at MI Integrated Ar-Rifqi. The data collection techniques used are performance tests and observation. The speaking skills of class VI MI Integrated Ar-Rifqi students before being given action achieved 32% classical completeness in the poor category. After taking action in cycle I, an average score of 66 was obtained with classical completeness of 54%, in cycle II there was an increase with an average score of 74 with classical completeness of 71% and in cycle III the score was obtained. an average of 81 with a classical completion score of 84%. Based on classical completeness, overall this research has reached ≥75% of the number of students who achieved the KKM, namely 84%. Thus, it shows that students' speaking skills after implementing the Running Dictation model in English learning have improved.
Environmental and behavioral variables associated with lower urinary tract diseases in domestic cats
Authors: Keskin Yılmaz Nevra 
Published: December 2023

Objectives: Feline lower urinary tract disease (LUTD) is a frequently seen disease with multiple etiologies. Since it is a complex condition, the aim of this study is to evaluate the factors that may affect the development of the disease.
Materials and Methods: Demographic, clinical, behavioral and environmental parameters of 30 cats diagnosed with lower urinary tract disease and 15 aged-matched healthy cats presented to Ankara University Small Animal Hospital were evaluated.
Results: In the diseased group, the male population was higher and the cats were overweight. The number of food, water and litter boxes and litter material were found to differ significantly between groups. Daily habits such as playing with a scratching board and self-grooming differed between the groups. Inappropriate behaviors observed by the owners of the cats in the first group were listed as urinating/defecating outside the litter box and showing aggression towards the owner, guests, and/or other animals.
Conclusions: The results of this study show that the detailed evaluation and regulation of the daily needs of cats is important for the emergence or recurrence of the disease and therefore may contribute to the correct management of the treatment process in cats with lower urinary tract disease.
On gamma T_pure submodules
Authors: Al-Hassani Uhood S. , Kadhim Samira Naji , Ali Muna Jasim Mohammed 
Published: December 2023

A gamma T_ pure sub-module also the intersection property for gamma T_pure sub-modules have been studied in this action. Different descriptions and discuss some ownership, as Γ-module Z owns the TΓ_pure intersection property if and only if (J2 ΓK ∩ J^2 ΓF)=J^2 Γ(K ∩ F) for each Γ-ideal J and for all TΓ_pure K, and F in Z Q/P is TΓ_pure sub-module in Z/P, if P in Q.
Cerebral disorders diagnosis via a secure transmission of multichannel EEG signal based on IoMT
Authors: Hammad Jamal A. , Hmeed Assef Raad , Obaid Ahmed J. 
Published: December 2023

Electroencephalogram (EEG) data require a wider storage device setup due to its constant brainwave intensity logs and biosignal parameter. Therefore, effective compression systems are utilized before sending these signals to a medical station such as hospitals and therapy centres or through mobile medical instruments as one of the Internet medical things (IoMT) tools for real-time surveillance and analysis by specialists and anywhere. Conventional compression techniques can improve storage efficiency and help quickly transfer medical data from one computer to another because of their limited size. In addition, the received EEG (MCh-EEG) data are processed using various filtering methods to remove undesired noise and then compressed. The proposed method, which utilized buffer blocks, which is quite new in this field, was proposed. The smooth and safe transmission process of multichannel EEG signals from the sensor to the surveillance is achieved by using highly effective methods to detect brainwaves, remove noise, compress and encrypt those signals. This work utilizes the mode of AES 256 BCM, which is rarely utilized in embedded systems, proving to be very powerful and effective in information ciphering. Based on the proposed system’s PRD parameter, the findings come as 0.41% and CR as 0.35%, and it’s better than the current schemes. Experimental findings demonstrate the effectiveness of the proposed systems on 10 different records of MCH-EEG signals from the CHB-MIT Scalp EEG dataset.
Observation of the supernova SN2023ixf in July 2023
Authors: Николенко И.В. , Аршинкин C.C. , Маслов И.А. , Шенаврин В.И. 
Published: December 2023

В июле 2023 г. были проведены наблюдения сверхновой SN2023ixf, с использованием нового поляриметра телескопа Цейсс-1000 Симеизской обсерватории ИНАСАН и инфракрасного фотометра ГАИШ (КАС МГУ). Приводятся спек- тральные потоки от сверхновой в стандартных полосах UBVRI JHKLM и оценки параметров линейной поляризации для полос BVRI.
In July 2023, observations of the Supernova SN2023ixf were carried out using the new polarimeter of the Zeiss-1000 telescope of the Simeiz Observatory INASAN and the infrared photometer of the Sternberg Astronomical Institute (MSU CAS). Spectral fluxes from a supernova in standard UBVRI JHKLM bands and linear polarization estimates for BVRI bands are given.