bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic behaviour restructuring mediates dopamine-dependent credit assignment
Authors: Tang Jonathan C. Y. , Paixao Vitor , Carvalho Filipe , Silva Artur , Klaus Andreas , da Silva Joaquim Alves , Costa Rui M. 
Published: December 2023

AbstractAnimals exhibit a diverse behavioural repertoire when exploring new environments and can learn which actions or action sequences produce positive outcomes. Dopamine release after encountering a reward is critical for reinforcing reward-producing actions1–3. However, it has been challenging to understand how credit is assigned to the exact action that produced the dopamine release during continuous behaviour. Here we investigated this problem in mice using a self-stimulation paradigm in which specific spontaneous movements triggered optogenetic stimulation of dopaminergic neurons. Dopamine self-stimulation rapidly and dynamically changes the structure of the entire behavioural repertoire. Initial stimulations reinforced not only the stimulation-producing target action, but also actions similar to the target action and actions that occurred a few seconds before stimulation. Repeated pairings led to a gradual refinement of the behavioural repertoire to home in on the target action. Reinforcement of action sequences revealed further temporal dependencies of refinement. Action pairs spontaneously separated by long time intervals promoted a stepwise credit assignment, with early refinement of actions most proximal to stimulation and subsequent refinement of more distal actions. Thus, a retrospective reinforcement mechanism promotes not only reinforcement, but also gradual refinement of the entire behavioural repertoire to assign credit to specific actions and action sequences that lead to dopamine release.
An integrated individual-level trait-based phytoplankton dataset from transitional waters
Authors: Laraib Maira , Titocci Jessica , Rosati Ilaria , Basset Alberto 
Published: December 2023

AbstractFunctional trait-based approaches have undergone an extraordinary expansion in phytoplankton ecology. Morpho-functional traits have been shown to vary both within and between populations and species, potentially affecting individual fitness and the network of inter-individual relationships. Here we integrate six fully harmonized phytoplankton morpho-functional trait datasets, characterized by a fine data grain, reporting individual-level data over a large biogeographical area. Datasets refer to transitional water ecosystems, from five biogeographical areas: Northern Atlantic Ocean (Scotland), South-Western Atlantic Ocean (Brazil), South-Western Pacific Ocean (Australia), Indo Pacific Ocean (Maldives) and Mediterranean Sea (Greece and Turkey). The integrated dataset includes 127311 individual phytoplankton records with sampling locations, taxonomic and morphometric information according to Darwin Core standards and semantic annotations. The six FAIR datasets are openly available in the LifeWatch Italy data portal. The datasets have already been used for morpho-functional analyses and hypothesis testing on phytoplankton guilds at different levels of data aggregation and scale, from local to global.
Towards understanding policy design through text-as-data approaches: The policy design annotations (POLIANNA) dataset
Authors: Sewerin Sebastian , Kaack Lynn H. , Küttel Joel , Sigurdsson Fride , Martikainen Onerva , Esshaki Alisha , Hafner Fabian 
Published: December 2023

AbstractDespite the importance of ambitious policy action for addressing climate change, large and systematic assessments of public policies and their design are lacking as analysing text manually is labour-intensive and costly. POLIANNA is a dataset of policy texts from the European Union (EU) that are annotated based on theoretical concepts of policy design, which can be used to develop supervised machine learning approaches for scaling policy analysis. The dataset consists of 20,577 annotated spans, drawn from 18 EU climate change mitigation and renewable energy policies. We developed a novel coding scheme translating existing taxonomies of policy design elements to a method for annotating text spans that consist of one or several words. Here, we provide the coding scheme, a description of the annotated corpus, and an analysis of inter-annotator agreement, and discuss potential applications. As understanding policy texts is still difficult for current text-processing algorithms, we envision this database to be used for building tools that help with manual coding of policy texts by automatically proposing paragraphs containing relevant information.
Chromosome-level genome assembly of the Asian spongy moths Lymantria dispar asiatica
Authors: Xu Zhe , Bai Jianyang , Zhang Yue , Li Lu , Min Mengru , Cao Jingyu , Cao Jingxin , Xu Yanchun , Li Fei , Ma Ling 
Published: December 2023

AbstractThe Asian spongy moth,Lymantria dispar asiatica, is one of the most devastating forestry defoliators. The absence of a high-quality genome limited the understanding of its adaptive evolution. Here, we conducted the first chromosome-level genome assembly ofL. dispar asiaticausing PacBio HIFI long reads, Hi-C sequencing reads and transcriptomic data. The total assembly size is 997.59 Mb, containing 32 chromosomes with a GC content of 38.91% and a scaffold N50 length of 35.42 Mb. The BUSCO assessment indicated a completeness estimate of 99.4% for this assembly. A total of 19,532 protein-coding genes was predicted. Our study provides a valuable genomics resource for studying the mechanisms of adaptive evolution and facilitate an efficient control ofL. dispar asiatica.
Epidemiological and clinical features of SARS-CoV-2 Omicron variant infection in Quanzhou, Fujian province: a retrospective study
Authors: Zhang Huatang , Weng Zhangyan , Zheng Yijuan , Zheng Minghui , Chen Wenhuang , He Haoyi , Ye Xiaoyi , Zheng Youxian , Xie Jianfeng , Zheng Kuicheng , Zhang Jiming , Zhuang Xibin , Su Zhijun , Zhou Yongjun , Yu Xueping 
Published: December 2023

AbstractEpidemiological and clinical data of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (BA.2) admitted to three designated hospitals in Quanzhou City, Fujian Province, China, were collected and analyzed. Overall, 2,541 patients infected with BA.2, comprising 1,060 asymptomatic, 1,287 mild, and 194 moderate infections, were enrolled. The percentage of moderate infections was higher in patients aged ≥ 60 years than in those aged < 18 years and 18–59 years. The median hospitalization duration was 17 days. Among the 2,541 patients, 43.52% had a clear history of close contact. The vaccination rate was 87.92%, and the percentage of asymptomatic infections was higher in vaccinated than in unvaccinated patients. Moreover, patients with underlying diseases, including hypertension and diabetes mellitus, had more moderate infections than those without underlying diseases. The three most common clinical manifestations were fever, dry cough, and sore throat. The albumin-to-globulin (A/G) ratio and lymphocyte count decreased in cases with mild and moderate infections, while procalcitonin, erythrocyte sedimentation rate, interleukin-6, D-dimer, and C4 levels increased. Advanced age, non-vaccination, and underlying comorbid diseases were high-risk factors for disease progression in patients. However, dynamic monitoring of blood routine parameters, A/G ratio, and inflammatory indicators facilitated the prediction of disease progression.
Inflammatory protein signatures in individuals with obesity and metabolic syndrome
Authors: Mir Fayaz Ahmad , Abdesselem Houari B. , Cyprian Farhan , Iskandarani Ahmad , Doudin Asmma , Samra Tareq A. , Alkasem Meis , Abdalhakam Ibrahem , Taheri Shahrad , Abou-Samra Abdul-Badi 
Published: December 2023

AbstractThere is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. The mechanisms contributing to this metabolic heterogeneity are not fully understood. To address this question, plasma samples from 48 individuals with BMI ≥ 35 kg/m2 were examined (27 with and 21 without metabolic syndrome). Fasting plasma samples were subjected to Olink proteomics analysis for 184 cardiometabolic and inflammation-enriched proteins. Data analysis showed a clear differentiation between the two groups with distinct plasma protein expression profiles. Twenty-four proteins were differentially expressed (DEPs) between the two groups. Pathways related to immune cell migration, leukocyte chemotaxis, chemokine signaling, mucosal inflammatory response, tissue repair and remodeling were enriched in the group with metabolic syndrome. Functional analysis of DEPs revealed upregulation of 15 immunological pathways. The study identifies some of the pathways that are altered and reflect metabolic health in individuals with obesity. This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.
Effect of external subretinal fluid drainage on persistent subretinal fluid after scleral buckle surgery in macula-involving rhegmatogenous retinal detachment
Authors: Do Jae Rok , Park Dong Ho , Shin Jae Pil , Kang Yong Koo 
Published: December 2023

AbstractThis study aimed to analyze the duration and causes of persistent subretinal fluid (PSF) after scleral buckle (SB) surgery in patients with macula-involving rhegmatogenous retinal detachment (RRD). Sixty-one eyes of 61 patients with macula-involving RRD who underwent SB surgery between 2016 and 2022 were reviewed retrospectively. PSF was confirmed on optical coherence tomography. The PSF duration after surgery and the analysis of relevant ocular and systemic factors were conducted according to the PSF duration. The mean duration of PSF was 5.9 ± 4.6 months in all eyes and 8.1 ± 5.0 months in eyes not treated with external subretinal fluid (SRF) drainage, which was significantly longer than 4.5 ± 3.7 months in those subjected to external SRF drainage. The mean best-corrected visual acuity improved significantly 3 months after surgery. There were significant visual improvements in the external SRF drainage group compared to the non-drainage group during all follow-up periods. Longstanding shallow RRD was significantly associated with longer PSF duration after SB surgery. External SRF drainage during SB surgery can effectively reduce SRF, shorten the duration of PSF, and accelerate visual improvement.
Van Krevelen diagrams based on machine learning visualize feedstock-product relationships in thermal conversion processes
Authors: Wang Shule , Wang Yiying , Shi Ziyi , Sun Kang , Wen Yuming , Niedzwiecki Lukasz , Pan Ruming , Xu Yongdong , Zaini Ilman Nuran , Jagodzińska Katarzyna , Aragon-Briceno Christian , Tang Chuchu , Onsree Thossaporn , Tippayawong Nakorn , Pawlak-Kruczek Halina , Jönsson Pär Göran , Yang Weihong , Jiang Jianchun , Kawi Sibudjing , Wang Chi-Hwa 
Published: December 2023

AbstractFeedstock properties play a crucial role in thermal conversion processes, where understanding the influence of these properties on treatment performance is essential for optimizing both feedstock selection and the overall process. In this study, a series of van Krevelen diagrams were generated to illustrate the impact of H/C and O/C ratios of feedstock on the products obtained from six commonly used thermal conversion techniques: torrefaction, hydrothermal carbonization, hydrothermal liquefaction, hydrothermal gasification, pyrolysis, and gasification. Machine learning methods were employed, utilizing data, methods, and results from corresponding studies in this field. Furthermore, the reliability of the constructed van Krevelen diagrams was analyzed to assess their dependability. The van Krevelen diagrams developed in this work systematically provide visual representations of the relationships between feedstock and products in thermal conversion processes, thereby aiding in optimizing the selection of feedstock and the choice of thermal conversion technique.
Aquatic food loss and waste rate in the United States is half of earlier estimates
Authors: Love David C. , Asche Frank , Fry Jillian , Nguyen Ly , Gephart Jessica , Garlock Taryn M. , Jenkins Lekelia D. , Anderson James L. , Brown Mark , Viglia Silvio , Nussbaumer Elizabeth M. , Neff Roni 
Published: December 2023

AbstractFood loss and waste (FLW) is a major challenge to food system sustainability, including aquatic foods. We investigated aquatic FLW in the food supply of the United States, the largest importer of aquatic food globally, using primary and secondary data and life cycle methodology. We show that there are significant differences in FLW among species, production technology, origin and stage of supply chain. We estimate total aquatic FLW was 22.7%, which is 43–55% lower than earlier estimates reported in the literature, illustrating the importance of applying a disaggregated approach. Production losses associated with imported food contribute over a quarter of total FLW, and addressing these losses requires multinational efforts to implement interventions along the supply chain. These findings inform prioritization of solutions—including areas of need for innovations, government incentives, policy change, infrastructure and equity.
High strength bio-concrete for the production of building components
Authors: Smirnova Maiia , Nething Christoph , Stolz Andreas , Gröning Janosch A. D. , Funaro Daniele P. , Eppinger Erik , Reichert Manuela , Frick Jürgen , Blandini Lucio 
Published: December 2023

AbstractThe production of bio-concrete is based on the process of microbially-induced calcium carbonate precipitation (MICP), in which calcium carbonate (CaCO3) is formed as a binder. Bio-concrete is a potentially CO2-neutral alternative to conventional Portland-cement-based concrete, since no process-related carbon dioxide emissions are generated during biomineralization. Furthermore, CO2 is bound in the form of carbonate. However, achieving compressive strength values comparable to conventional concrete, in combination with sufficient component depth, has been a significant challenge in the MICP research. In the present study, a combination of methods was implemented, including the use of urease-active calcium carbonate powder (UACP) instead of free bacterial cells, optimization of aggregate packing density, and the implementation of an automated stop-flow pressure injection method. A variety of cementation parameters were tested to determine the optimal conditions for the production of homogeneously cemented high strength bio-concrete. Additionally, reproducibility and optimization studies have been conducted with selected parameter combinations. It was found that achieving homogeneous compaction with sufficient aggregate packing density played a crucial role in obtaining consistent and high-quality cementation results. A combination of a very high compressive strength of 52.5 MPa and a cementation depth of 140 mm has been reached, which has not been reported in previous publications. These findings might unveil new possibilities for bio-concrete to be used in the production of prefabricated load-bearing building components, where it could partially replace traditional concrete.
Eine hundertprozentige Sicherheit gibt es nicht
Authors: Nienaber André , Breinbauer Irmi 
Published: December 2023

ZUSAMMENFASSUNGDas Thema Sicherheit spielt in der akutpsychiatrischen Versorgung eine zentrale Rolle. So gehört die Schaffung einer sicheren Umgebung für Patienten in akuten psychiatrischen Ausnahmesituationen zu den zentralen Aufgaben einer psychiatrischen Akutstation. Doch was bedeutet Sicherheit in diesem Zusammenhang genau? Der Artikel beschäftigt sich mit dem Begriff der Sicherheit und diskutiert Möglichkeiten zur Verbesserung von Sicherheit in multiprofessionellen Teams in der stationären akutpsychiatrischen Versorgung aus einer pflegefachlichen bzw. pflegewissenschaftlichen Perspektive.
Die Mitochondriopathie Diabetes mellitus – Intervention mit
(Mikro-)Nährstoffen: Update 2023
Authors: Gröber Uwe , Friedrichsen Hans-Peter 
Published: December 2023

ZusammenfassungBei diabetischer Stoffwechsellage kommt es in den Mitochondrien zur massiven
Bildung von Superoxidradikalen, wodurch diabetesspezifische Signalwege aktiviert
werden. Oxidativer und nitrosativer Stress mit Inflammation verknüpfen
bei genetischer Prädisposition und ungünstigem Lebensstil den
Typ-2-Diabetes mit schwerwiegenden Folgeerkrankungen wie Angio- und
Neuropathien. Neben einer frühzeitigen Diagnostik und optimalen
Stoffwechseleinstellung sollte bei Diabetes mellitus rechtzeitig durch
Interventionen in die pathologischen Prozesse der Angio- und Neuropathien
eingegriffen werden. Eine vielversprechende komplementär- und
präventivmedizinische Therapieoption ist die gezielte
frühzeitige Supplementierung mitochondrienprotektiver, antioxidativer
und den Kohlenhydratstoffwechsel-regulierender (Mikro-)Nährstoffe wie
Vitamin C, Coenzym Q10, B-Vitamine, Vitamin D, Vitamin K und Magnesium.
Safety or security?
Authors: Mahler Lieselotte , Oster Anna 
Published: December 2023

ZUSAMMENFASSUNGWas bedeutet Sicherheit in der Akutpsychiatrie? Für wen ist was sicher? Wo können wir ansetzen, um mit Unsicherheiten sicher arbeiten zu können? Sicherheit ist ein komplexes Konstrukt. In der Diskussion um Sicherheit in der Akutpsychiatrie müssen verschiedene Dimensionen und Perspektiven der Sicherheit beachtet werden. Basierend auf praktischen Erfahrungen und wissenschaftlicher Evidenz werden Ansatzpunkte innerhalb und außerhalb der psychiatrischen Versorgungsstrukturen für eine sichere Psychiatrie diskutiert.
Stellungnahme zur Altersuntergrenze bei der ambulanten Durchführung von Adenotomien und Tonsillotomien
Authors: Deitmer T. , Beck C. E. , Becke-Jakob K. , Eich C. , Hackenberg S. , Hoffmann T. K. , Koitschev A. , Löhler J. , Röher K. , Sittel C. , Welkoborsky H. J. , Wienke A. , Badelt G. 
Published: December 2023

ZusammenfassungMit Beginn des Jahres 2023 haben sich in der Regelung für das ambulante Operieren in Deutschland erhebliche Änderungen ergeben, die in einem trilateralen Vertrag der Selbstverwaltung zwischen dem Spitzenverband der gesetzlichen Krankenversicherungen, der Deutschen Krankenhausgesellschaft und der Kassenärztlichen Bundesvereinigung niedergelegt wurden. Hier wurden unter anderem in einem Katalog Tatbestände angegeben, unter denen eine Operation nicht oder nur fraglich ambulant durchgeführt werden sollte. In diesem Katalog wurde zum Patientenalter ausgeführt: „Bis zur Vollendung des ersten Lebensjahres kann eine stationäre Durchführung einer Leistung begründet sein.“ Diese Formulierung für sich bedeutet, dass Kinder ab einem Jahr regelhaft ambulant zu operieren sind.In den wissenschaftlichen Fachgesellschaften für HNO-Heilkunde, Kopf und Halschirurgie sowie für Anästhesiologie und Intensivmedizin regten sich Zweifel, ob diese Altersgrenze auch für Operationen im Rachen wie Adenotomie oder Tonsillotomie wissenschaftlich begründbar sei.Es wurde eine Recherche in internationalen Leitlinien sowie in der internationalen Literatur durchgeführt und die dortigen Aussagen bewertet. Die Ergebnisse dieser Literaturrecherche wurden mit Vertretern der Arbeitsgemeinschaft Pädiatrische HNO-Heilkunde (AG PädHNO), der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO-KHC) und dem wissenschaftlichen Arbeitskreis Kinderanästhesie (WAKKA) der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI) in Konferenzen beraten.Diese Konsensfindung ergab, dass eine strikte Altersgrenze mit dem vollendeten ersten Lebensjahr für die ambulante Durchführung von Adenotomien und Tonsillotomien nicht sachgerecht ist. Zunächst ist überhaupt die Angabe einer strikten Altersgrenze fragwürdig, da unabhängig vom Alter etliche andere medizinische und soziale Faktoren Einfluss auf die verantwortungsvolle Durchführbarkeit ambulanter Operationen haben. Im Weiteren ist die Altersgrenze von einem Jahr mit Blick auf Literatur, Leitlinien und praktische Ausübung im internationalen Bereich nicht als sachgerecht anzusehen. Die Bewertung der Literatur und die Beachtung der Durchführung im internationalen Bereich lassen eine Altersgrenze eher in dem Bereich von 2–3 Jahren als sachgerecht erscheinen.Diese Übersichtsarbeit gibt den verantwortlichen Ärzten vielerlei Erkenntnisse, Aspekte und Argumente an die Hand, um die Entscheidung zur ambulanten oder stationären Durchführung dieser Operationen sachgerecht und verantwortungsvoll treffen zu können.
Pd-Catalyzed Oxidative Functionalization of Alkenes, Arenes, and 1,3-Dienes Using Molecular Oxygen as the Terminal Oxidant
Authors: Obora Yasushi , Tabaru Kazuki 
Published: December 2023

AbstractThis Account presents palladium-complex-catalyzed oxidative couplings mainly developed by the author’s group, including oxidative amination and silylation of terminal alkenes, direct oxidative arylation of aromatic compounds, and oxidative difunctionalization of 1,3-dienes. The catalytic cycles in these representative reactions feature re-oxidation of the palladium species with molecular oxygen as the terminal oxidant. Varying the combination of palladium catalyst and re-oxidant enables the formation of a variety of bonds through dehydrogenative cross-coupling reactions.1	Introduction2	Oxidative Amination of Terminal Alkenes3	Direct Oxidative Arylation of Aromatic Compounds4	Oxidative Silylation of Terminal Alkenes5	Oxidative Difunctionalization of 1,3-Dienes6	Conclusions and Perspectives
Deep Learning-Based Retinal Layer Segmentation in Optical Coherence Tomography Scans of Patients with Inherited Retinal Diseases
Authors: Eckardt Franziska , Mittas Robin , Horlava Nastassya , Schiefelbein Johannes , Asani Ben , Michalakis Stylianos , Gerhardt Maximilian , Priglinger Claudia , Keeser Daniel , Koutsouleris Nikolaos , Priglinger Siegfried , Theis Fabian , Peng Tingying , Schworm Benedikt 
Published: December 2023

Abstract
Background In optical coherence tomography (OCT) scans of patients with inherited retinal diseases (IRDs), the measurement of the thickness of the outer nuclear layer (ONL) has been
well established as a surrogate marker for photoreceptor preservation. Current automatic segmentation tools fail in OCT segmentation in IRDs, and manual segmentation is time-consuming.
Methods and Material Patients with IRD and an available OCT scan were screened for the present study. Additionally, OCT scans of patients without retinal disease were included to
provide training data for artificial intelligence (AI). We trained a U-net-based model on healthy patients and applied a domain adaption technique to the IRD patientsʼ scans.
Results We established an AI-based image segmentation algorithm that reliably segments the ONL in OCT scans of IRD patients. In a test dataset, the dice score of the algorithm was
98.7%. Furthermore, we generated thickness maps of the full retinal thickness and the ONL layer for each patient.
Conclusion Accurate segmentation of anatomical layers on OCT scans plays a crucial role for predictive models linking retinal structure to visual function. Our algorithm for
segmentation of OCT images could provide the basis for further studies on IRDs.