bluuebunny/crossref_metadata_2025_split huggingface dataset:
Komunikasi Lingkungan Di Masjid Al-Azhar Dalam Menumbuhkan Kepedulian Jama’ah Terhadap Penanganan Sampah
Authors: Kurniawan Dani , Muhammad Zulfi Ifani  
Published: November 2023

Sampah sekarang menjadi masalah utama dalam sebuah wilayah. Salah satunya di kawasan DIY. Hal ini dikarenakan volume sampah yang tidak terkendali sehingga Tempat Pembuangan Sampah (TPS) di Piyungan Kabupaten Bantul ditutup sekitar dua bulan (juli-september 2023). Atas dasar itulah, peneliti memilih daerah tersebut sebagai lokasi penelitian, tepatnya di RW 06 Suryowijayan Kecamatan Matrijeron Kota Yogyakarta.
Tujuan penelitian ini adalah untuk mendapatkan model komunikasi yang tepat dari komunitas sosial masyarakat (jama’ah Masjid Al-Azhar) dalam membangun kepedulian masyarakat terhadap penanganan sampah. Teori dalam riset ini menggunakan komunikasi lingkungan dengan pendekatan strategi memilih media, strategi desain intruksional dan strategi partisapasi.
Penelitian ini menggunakan pendekatan diskriptif kualitatif. Adapun hasil penelitian menunjukan seluruh jama’ah (anak-anak, remaja, dewasan dan orang tua) Masjid Al-Azhar telah mendapatkan sosialisasi atau kampanye tentang kepedulian terhadap sampah. Kemudian jama’ah anak-anak dan ibu-ibu lebih mudah menerima terhadap isu tersebut. Hal ini ditunjukan dengan keaktifan mengikuti kegiatan recycle sampah.
Antibacterial and Phytochemical Properties of Clove Extracts on Vegetable Spoilage Bacteria
Authors: Kalu Success Eni , Chigbu Charles Chukwuemeka , Eyibio Jedidiah Solomon 
Published: November 2023

The present study was carried out to analyze the antibacterial and phytochemical properties of clove extracts on vegetable spoilage bacteria. The study seeks to determine its potential use as bio-preservative. The bacteria used for this study were isolated from infected leaves of bitter leaf, pumpkin and cocoyam using spread plate technique. Phytochemical analysis was carried out with aqueous and methanol extracts. Bacterial isolates from the leaves included Bacillus spp., Micrococcus spp., Staphylococcus spp. and Actinomyces spp. The pumpkin leaf had the highest average number of bacterial colonies of 2.5 x 102 while cocoyam leaf had the least with 7.0 x 101.Actinomycetes sp2 had the highest zone of inhibition of 22.0 mm while Staphylococcus sp2 had the least zone of inhibition of 13.00 mm all at 500mg/ml. For aqueous extracts, Bacillus sp.3, Staphylococcus sp.1 had the highest zone of inhibition of 16.00 mm respectively while the least zones were observed in Staphylococcus sp.2 and Bacillus sp.3 at concentration of 250 mg/ml and 125 mg/ml respectively. Bacillus sp.1, Bacillus sp.2, Micrococcus sp. and Actinomyces sp.1 has Minimum Inhibition Concentration (MIC) of 125 mg/ml while Staphylococcus sp.1 and Staphylococcus sp.2 has 250mg/ml respectively for methanol extract. For aqueous extract, Bacillus sp.2, Micrococcus sp. and Actinomyces sp.1 has MIC of 250mg/ml, respectively and Staphylococcus sp.1 and Staphylococcus sp.2 has MIC of 500 mg/ml. The Minimum Bactericidal Concentration (MBC) for the methanol extracts was 125 mg/ml for Actinomyces sp.1 while Bacillus sp.2, Bacillus sp.3, Micrococcus sp. and Actinomyces sp.2 were 250 mg/ml respectively while Bacillus sp1, Bacillus sp2, Micrococcus sp., Staphylococcus sp.2 and Actinomyces sp.1 all has MBC of 500mg/ml, respectively on the aqueous extracts. The phytochemical analysis of the aqueous and methanol extracts of clove shows that saponins, tannins, amino acids, proteins, reducing sugar, glycosides, alkaloids, anthraquinone and phenols are present though in varying amounts. This study therefore recommends clove extract as an alternative source for bio-preservation in food and allied products.
Healthcare use is elevated two decades before a first demyelinating event and differs by age and sex
Authors: Tremlett Helen , Zhu Feng , Everett Karl , Asaf Ayesha , Manouchehrinia Ali , Li Ping , McKay Kyla A. , Hillert Jan , Zhao Yinshan , Maxwell Colleen , Marrie Ruth Ann 
Published: January 2025

AbstractObjectiveElevated healthcare use before multiple sclerosis (MS) onset suggests earlier opportunity to identify MS. Yet their timing and sociodemographic effects are unclear. We examined rates of healthcare use (and by age/sex) for >two decades pre‐MS onset.MethodsWe identified people with MS (PwMS) using administrative data from Canada (Ontario) and Sweden (1991–2020) (“administrative” cohort), and the Swedish MS Registry (“clinical” cohort). The first MS/demyelinating diagnostic code (administrative) or symptom onset (clinical) defined MS onset. We compared annual rates of healthcare use (hospital, physician, and emergency‐room [ED]) pre‐onset between PwMS and up to five matched population controls using negative binomial regression, and by age/sex.ResultsThe administrative cohort = 35,018/136,007 PwMS/controls (Ontario), and 10,269/51,297 (Sweden). Rates of healthcare use were higher for PwMS than controls up to 28 (of 29) years (Ontario) and up to 15 (of 19) years (Sweden) pre‐onset. Annual healthcare use rose steadily as onset approached, particularly escalating 7 years pre‐onset in Ontario (e.g., hospital visit rate ratios [RRs] exceeded 1.30), and 6 years in Sweden (physician visit RRs > 1.10). RRs peaked the year pre‐onset (ED visits [Ontario] = 3.04; 95% CI: 2.94–3.13, physician visits [Sweden] = 2.51; 95% CI: 2.44–2.59). In the year pre‐onset, RRs were disproportionately higher for males (ED RRs [Ontario] = 3.30; 95% CI: 3.13–3.48 vs. females = 2.90; 95% CI: 2.79–3.02), and dropped steadily by age (physician visit RRs [Sweden] = 2.61/2.27/1.97/1.72 for 50/40/30/20‐year‐olds). The smaller clinical cohort (7604/37,974 PwMS/controls) exhibited similar patterns, albeit more modest, with RRs elevated up to 5 years pre‐onset (physician visit RR [year‐5] = 1.08; 95% CI: 1.02–1.14; RR [year‐1] = 1.39;1.33–1.46).InterpretationHigher healthcare use was evident decades before MS onset, escalating 6–7 years pre‐onset, peaking the year before, being disproportionately higher for males and older PwMS.
Tough and Fast Thermoresponsive Hydrogel Soft Actuators
Authors: Zhang Xi , Aziz Shazed , Zhu Zhonghua 
Published: January 2025

AbstractThermoresponsive hydrogels hold significant potential for soft actuators due to their ability to undergo reversible shape deformation in response to temperature changes. However, the mechanical brittleness along with slow actuation responsiveness of such hydrogels limit their usage in high‐stress environments. Herein, the design and fabrication of tough and fast‐responding thermoresponsive double‐network (DN) hydrogels, specifically developed for use in soft actuators, are introduced. Using a one‐pot free‐radical polymerization method, DN hydrogels composed of a poly(N‐isopropylacrylamide) (PNIPAm) thermoresponsive first network and an ether‐based polyurethane (EPU) second network, providing both mechanical strength and fast response to temperature variation are synthesized. The fabricated hydrogels exhibit excellent mechanical properties, with an ultimate compressive stress of ≈8 MPa, and demonstrate rapid actuation, achieving ≈30% linear contraction and ≈28% radial contraction within 2 min under hydrothermal conditions at 50 °C. Furthermore, tubular soft actuators fabricated from these hydrogels demonstrate the ability to act as fluidic temperature sensors, automatically switching fluid flow direction in response to temperature change. These DN hydrogels combine toughness, rapid actuation, and temperature sensing, offering substantial advancements for soft robotics and adaptive systems.
Integration of Pt/Fe‐silicalite‐1 and acidic zeolite as a bifunctional catalyst for boosting ethane dehydroaromatization
Authors: Wu Lizhi , Zhang Ying , Zou Caixin , Sun Qin , Li Baozhen , Zheng Wenchun , Liu Jiamin , He Juncheng , Tang Yu , Tan Li 
Published: January 2025

AbstractEthane dehydrogenation to aromatics (EDA) is one of the most promising routes to produce aromatics. Herein, the tandem of dehydrogenation component and acidic zeolite are prepared and investigated for EDA. Pt/Fe‐S‐1 coupled with ZSM‐5 of Si/Al of 14 via mixing homogeneously shows excellent EDA performance with 54.0% ethane conversion, 61.5% aromatics selectivity as well as a deactivation rate constant of 0.00010 h−1. According to catalysts characterizations and controlled experiments, it is confirmed the highly dispersed positive Ptδ+ species around Fe species over Pt/Fe‐S‐1 is the active sites for ethane dehydrogenation to ethylene and subsequent naphthenes dehydrogenation to aromatics, Brønsted acid sites of ZSM‐5 and MFI pore are responsible for ethylene oligomerization and cyclization to naphthenes and further naphthenes dehydrogenation to aromatics. The short spatial space between dehydrogenation active sites and acid sites is beneficial for EDA. And the ethylene generation rate is the rate‐determining step of EDA.
Elderly Patients With Aplastic Anemia: Treatment Patterns and Outcomes in the Real World
Authors: Fattizzo Bruno , Gurnari Carmelo , Giammarco Sabrina , Ricchiuti Antony , Awada Hussein , Bortolotti Marta , Galli Nicole , Pedone Giacinto Luca , Versino Francesco , Consonni Dario , Trikha Roochi , Gandhi Shreyans , Sica Simona , Maciejewski Jaroslaw P. , Kulasekararaj Austin , Barcellini Wilma 
Published: January 2025

ABSTRACTWe retrospectively analyzed a large international cohort of 1113 patients with aplastic anemia to evaluate treatment choice and outcome in elderly patients as compared with a younger population. Overall, 319 (29%) patients were > 60 years old at diagnosis (60–64 years (n = 85), 106 65–69 years (n = 106), and 128 > 70 years (n = 128)). Elderly patients showed a more severe thrombocytopenia at onset and a significantly lower overall response (complete plus partial) to first‐line therapy at 6 months as compared to younger patients (47% vs. 65%, p < 0.0001), irrespective of treatment modality (ATG or CyA combinations, eltrombopag, or androgens); 27 (8%) received transplant as second line therapy and 11 (41%) died, mainly due to transplant complications. The rate of evolution to MDS was greater in elderly patients (12% vs. 7% in younger AA, p = 0.002), whilst the rate of evolution to AML was similar (1.8 vs. 1.3%). By multivariable analysis, older age remained the main factor associated with mortality [HR 1.64 (95% CI 1.5–1.7), p < 0.001], followed by disease severity by Camitta classification [HR 2.24 (95% CI 1.6–3.1) for severe AA; HR 3.8 (95% CI 2.4–6) for very severe AA], and male gender [1.45 (95% CI 1.1–1.8), p < 0.001]. In this large study, elderly AA was associated with inferior outcome even in the TPO‐RA era, highlighting the need for further optimization of clinical management.
Iron‐associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice
Authors: Thorwald Max A. , Godoy‐Lugo Jose A. , Garcia Gilberto , Silva Justine , Kim Minhoo , Christensen Amy , Mack Wendy J. , Head Elizabeth , O'Day Peggy A. , Benayoun Bérénice A. , Morgan Todd E. , Pike Christian J. , Higuchi‐Sanabria Ryo , Forman Henry Jay , Finch Caleb E. 
Published: January 2025

AbstractINTRODUCTIONIron‐mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.METHODSTo further resolve mechanisms of iron‐mediated toxicity in AD, we analyzed post mortem human brain and ApoEFAD mice.RESULTSAD brains had decreased antioxidant enzymes, including those mediated by glutathione (GSH). Subcellular analyses of AD brains showed greater oxidative damage and lower antioxidant enzymes in lipid rafts, the site of amyloid processing, than in the non‐raft membrane fraction. Apolipoprotein E ε4 carriers had lower lipid raft yield with greater membrane oxidation. The hypothesized role of iron in AD pathology was tested in ApoEFAD mice by iron chelation with deferoxamine, which decreased fibrillar amyloid and lipid peroxidation, together with increased GSH‐mediated antioxidants.DISCUSSIONThese novel molecular pathways highlight iron‐mediated damage to lipid rafts during AD.Highlghts
Alzheimer's disease (AD) brains have numerous markers for ferroptosis, including increased lipid peroxidation, reduced antioxidant levels, and increased iron storage.
Lipid rafts in AD cases have increased oxidative damage and reduced antioxidant enzyme levels and activity which are most severe in apolipoprotein E ε4 carriers.
Neuronal markers are correlated with lipid peroxidation, antioxidant defense, and iron signaling proteins suggesting that neuronal loss is linked to these events.
Chelation of iron in the early‐onset familial AD model reduces iron‐mediated lipid peroxidation and fibrillar amyloid.
APP antisense oligonucleotides are effective in rescuing mitochondrial phenotypes in human iPSC‐derived trisomy 21 astrocytes
Authors: Thirumalai Srishruthi , Livesey Frederick J. , Patani Rickie , Hung Christy 
Published: January 2025

AbstractINTRODUCTIONAntisense oligonucleotides (ASOs) have shown promise in reducing amyloid precursor protein (APP) levels in neurons, but their effects in astrocytes, key contributors to neurodegenerative diseases, remain unclear. This study evaluates the efficacy of APP ASOs in astrocytes derived from an individual with Down syndrome (DS), a population at high risk for Alzheimer's disease (AD).METHODSHuman induced pluripotent stem cells (hiPSCs) from a healthy individual and an individual with DS were differentiated into astrocytes. Astrocytes were treated with APP ASOs for 10 days, and APP levels were quantified. Mitochondrial morphology and superoxide production in DS astrocytes were analyzed using super‐resolution and confocal microscopy.RESULTSAPP ASOs significantly reduced APP levels in astrocytes from both control and DS individuals. In DS astrocytes, treatment restored mitochondrial health, increasing mitochondrial number and size while reducing superoxide production.DISCUSSIONAPP ASOs effectively reduce APP levels and improve mitochondrial health in astrocytes, suggesting their potential as a therapeutic approach for DS and DS‐related AD. Further in vivo studies are required to confirm these findings.Highlights
APP ASOs reduce APP levels in human iPSC‐derived astrocytes.
APP ASO treatment rescues mitochondrial phenotypes in trisomy 21 astrocytes.
This study supports ASOs as a potential therapy for Down syndrome‐related Alzheimer's disease.
Bias‐Induced Ga−O‐Ir Interface Breaks the Limits of Adsorption‐Energy Scaling Relationships for High‐Performing Proton Exchange Membrane Electrolyzers
Authors: Qian Yinnan , Guo Yirun , Yang Zijie , Luo Zhaoyan , Zhang Lei , Zhang Qianling , He Chuanxin , Zhang Hao , Sun Xueliang , Ren Xiangzhong 
Published: January 2025

AbstractRationally manipulating the in situ formed catalytically active surface of catalysts remains a significant challenge for achieving highly efficient water electrolysis. Herein, we present a bias‐induced activation strategy to modulate in situ Ga leaching and trigger the dynamic surface restructuring of lamellar Ir@Ga2O3 for the electrochemical oxygen evolution reaction. The in situ reconstructed Ga−O−Ir interface sustains high water oxidation rates at oxygen evolution reaction (OER) overpotentials. We found that OER at the Ga−O−Ir interface follows a bi‐nuclear adsorbate evolution mechanism with unsaturated IrOx as the active sites, while GaOx atoms play an indirect role in promoting water dissociation to form OH* and transferring OH* to Ir sites. This breaks the scaling relationship of the adsorption energies between OH* and OOH*, significantly lowering the energy barrier of the rate‐limiting step and greatly increasing reactivity. The Ir@Ga2O3 catalyst achieves lower overpotentials, a current density of 2 A cm−2 at 1.76 V, and stable operation up to 1 A cm−2 in scalable proton exchange membrane water electrolyzer (PEMWE) at 1.63 V, maintaining stable operation at 1 A cm−2 over 1000 hours with a degradation rate of 11.5 μV h−1. This work prompted us to jointly address substrate–catalyst interactions and catalyst reconstruction, an underexplored path, to improve activity and stability in Ir PEMWE anodes.
In situ Polymerization Induced Seed‐Root Anchoring Structure for Enhancing Stability and Efficiency in Perovskite Solar Modules
Authors: Li Sibo , Xu Xiaowei , Wang Xin , Huang Nuanshan , Fang Jun , Lin Dongxu , Shao Yueyue , Zhou Jia , Kyaw Aung Ko Ko , He Sisi , Qiu Longbin 
Published: January 2025

AbstractThe escape of organic cations over time from defective perovskite interface leads to non‐stoichiometric terminals, significantly affecting the stability of perovskite solar cells (PSCs). How to stabilize the interface composition under environmental stress remains a grand challenge. To address this issue, we utilize thiol‐functionalized particles as a “seed” and conduct in situ polymerization of 2,2,3,4,4,4‐hexafluorobutyl methacrylate (HFMA) as a “root” at the bottom of the perovskite layer. In this process, the thiol group acts as the initiation site for the polymerization of HFMA, while the fluorine groups in HFMA firmly anchor the organic cations of the perovskite through multiple hydrogen bonds. This strategy resembles how seeds take root in soil to prevent soil erosion. This bionic seed‐rooting structure effectively stabilizes the stoichiometry of the perovskite, thus suppressing the escape of organic cations. As a result, the perovskite films with seed‐rooting structures exhibit enhanced stability under harsh vacuum thermal conditions (150 °C, <10 Pa). The resulting PCS achieves an efficiency of 25.64 % and a 22.4 cm2 module efficiency of 22.61 %. After 1300 hours of 1‐sun illumination at 85 % relative humidity and 65 °C (ISOS−L‐3 protocol), the perovskite solar module maintains 90 % of its initial efficiency.
Targeted Docking of Localized Hydrogen Bond for Efficient and Reversible Zinc‐Ion Batteries
Authors: Wang Pinji , Li Tian Chen , Liu Yanfen , Lin Congjian , Cui Yangfeng , Song Haobin , Lu Bingan , Liang Shuquan , Yang Hui Ying , Zhou Jiang 
Published: January 2025

AbstractHydrogen bond (HB) chemistry, a pivotal feature of aqueous zinc‐ion batteries, modulates electrochemical processes through weak electrostatic interactions among water molecules. However, significant challenges persist, including sluggish desolvation kinetics and inescapable parasitic reactions at the electrolyte‐electrode interface, associated with high water activity and strong Zn2+‐solvent coordination. Herein, a targeted localized HB docking mechanism is activated by the polyhydroxy hexitol‐based electrolyte, optimizing Zn2+ solvation structures via dipole interaction and reconstructing interfacial HB networks through preferential parallel adsorption. By combining in situ spectroscopic characterizations with theoretical calculations, we elucidate the dynamic evolution of localized HB networks, which enhance Zn2+ deposition kinetics and homogeneity, suppress water‐induced side reactions, and mitigate vanadium framework collapse. Our findings support that the targeted HB docking strategy facilitates fast interfacial ion transport kinetics and enables high reversibility, with a substantially prolonged symmetric cell lifespan exceeding 5000 h. This work markedly advances the efficient and reversible zinc‐based batteries.
Realizing a 3 C Fast‐Charging Practical Sodium Pouch Cell
Authors: Zhao Jinhui , Lan Hao , Yang Guangze , Zhu Qiaonan , Dong Shuai , Jiang Li , Wang Gongkai , Wei Wenshuo , Wu Liqiang , Zhou Bin , Yang Daojun , Chen Jiangchun , Yang Jie , Kurbanov Mirtemir , Wang Hua 
Published: January 2025

AbstractSodium‐ion batteries (SIBs), endowed with relatively small Stokes radius and low desolvation energy of Na+, are reckoned as a promising candidate for fast‐charging endeavors. However, the C‐rate charging capability of practical energy‐dense sodium‐ion pouch cells is currently limited to ≤1 C, due to the high propensity for detrimental metallic Na plating on the hard carbon (HC) anode at elevated rates. Here, an ampere‐hour‐level sodium‐ion pouch cell capable of 3 C charging is successfully developed via phosphorus (P)‐sulfur (S) interphase chemistry. By rational electrolyte regulation, desired P−S constituents, namely, Na3PO4 and Na2SO4, are generated in the solid‐electrolyte interphase with favorable Na+ interface kinetics. Specifically, Na+ desolvation energy barrier has been greatly lowered by the weak ion‐solvent coordination near the inner Helmholtz plane on Na3PO4 interphase, while Na2SO4 expedites charge carrier mobility due to its intrinsically high ionic conductivity. Consequently, an energy‐dense (126 Wh kg−1) O3‐Na(Ni1/3Fe1/3Mn1/3)O2||HC pouch cell capable of 3 C charging (100 % state of charge) without Na plating can be achieved, with a great capacity retention of 91.5 % over 200 cycles. Further, the assembled power‐type Na3V2(PO4)3||HC pouch cell displays an impressive fast‐charging capability of 50 C, which surpasses that of previously reported high‐power SIBs. This work serves as an enlightenment for developing fast‐charging SIBs.
Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2
Authors: Ceylan Betül , Adam Jennifer , Toews Sabrina , Kaiser Frank , Dörr Jonas , Scheppa Daniel , Tants Jan‐Niklas , Smart Alexandria , Schoth Julian , Philipp Susanne , Stirnal Elke , Ferner Jan , Richter Christian , Sreeramulu Sridhar , Caliskan Neva , Schlundt Andreas , Weigand Julia E. , Göbel Michael , Wacker Anna , Schwalbe Harald 
Published: January 2025

AbstractTargeting the RNA genome of SARS‐CoV‐2 is a viable option for antiviral drug development. We explored three ligand binding sites of the core pseudoknot RNA of the SARS‐CoV‐2 frameshift element. We iteratively optimized ligands, based on improved affinities, targeting these binding sites and report on structural and dynamic properties of the three identified binding sites. Available experimental 3D structures of the pseudoknot element were compared to SAXS and NMR data to validate its dominant folding state in solution. In order to experimentally map in silico predicted binding sites, NMR assignments of the majority of nucleobases were achieved by segmental labeling of the pseudoknot RNA and isotope‐filtered NMR experiments at 1.2 GHz, demonstrating the value of NMR spectroscopy to supplement modelling and docking data. Optimized ligands with enhanced affinity were shown to specifically inhibit frameshifting without affecting 0‐frame translation in cell‐free translation assays, establishing the frameshift element as target for drug‐like ligands of low molecular weight.
Enantioselective Borylcupration/Cyclization of Alkene‐Tethered Oxime Esters
Authors: Bajohr Jonathan , Li Shangyu , Mirabi Bijan , Johnson Colton E. , Lautens Mark 
Published: January 2025

AbstractA copper‐catalyzed enantioselective synthesis of borylated 1‐pyrrolines from γ,δ‐unsaturated oxime esters is reported. Twenty‐four novel 1‐pyrroline derivatives are reported in yields ranging from 26% to 96% and enantioselectivities from 74.5:25.5 er to 99:1 er. Examples derived from α‐unsubstituted, non‐fluorinated oxime esters are reported. The hydroxyl group following oxidation of the Bpin moiety acts as a directing group in highly diastereoselective reductions of the pyrrolines to the corresponding prolinol derivatives. Additionally, the Bpin group can be retained in the products following a simplified, chromatography‐free workup procedure. DFT supports a reaction mechanism which proceeds through the formation of an (R)‐benzylic copper intermediate, followed by stereoretentive cyclization with respect to the configuration at the metalated carbon. The conclusions of the computational data are corroborated through control experiments and deuterium‐labelling studies.