bluuebunny/crossref_metadata_2025_split huggingface dataset:
HNF1A gene mutations and premature ovarian failure (POF): evidence from a clinical paradigm combining MODY 3 and POF
Authors: Xekouki P. , Konstantinidou A. , Tatsi C. , Sertedaki A. , Settas N. , Loutradis D. , Chrousos G. P. , Kanaka-Gantenbein C. , Dacou-Voutetakis C. , Voutetakis A. 
Published: February 2024

AbstractPremature ovarian failure (POF) defines the occurrence of ovarian failure prior to the age of 40. It occurs in one out of 100 women but is very rare before age 20 (1:10,000). Maturity-onset diabetes of the young (MODY), caused by mutations in the HNF1A gene, is also a rare disorder; all types of MODY account for 1–2% of adult diabetic cases. These two rare nosologic entities coexisted in an adolescent girl evaluated for delayed puberty. Although this combination could represent a chance association, an interrelation might exist. We examined HNF1A expression in human fetal and adult ovaries by immunohistochemistry using a polyclonal HNF1A antibody. HNF1A protein was expressed in both the fetal and adult human ovaries. Based on these findings, we hypothesize that HNF1A participates in ovarian organogenesis and/or function and that mutations in the HNF1A gene might represent another molecular defect causing POF, possibly in combination with other genetic factors. The study underlines the importance of rare clinical paradigms in leading the way to elucidation of the pathogenetic mechanisms of rare diseases.
Anti-vaccine rabbit hole leads to political representation: the case of Twitter in Japan
Authors: Toriumi Fujio , Sakaki Takeshi , Kobayashi Tetsuro , Yoshida Mitsuo 
Published: February 2024

AbstractAnti-vaccine attitudes pose a threat to public health by impeding the development of herd immunity. However, the proliferation and politicization of anti-vaccine discourse, exacerbated by the pandemic and the rise of social media, have not been fully elucidated. This study, using Japanese Twitter data, revealed that (a) anti-vaxxers are characterized by high political interest, (b) persistent anti-vaxxers were more ideologically left-leaning and had stronger ties to existing political parties, and (c) pandemic-induced new anti-vaxxers displayed low political engagement but a greater affinity for conspiracy theories, spirituality, naturalism, and alternative health practices, which served as gateways to anti-vaccination views. Furthermore, those who turned anti-vaccine after the pandemic also exhibited an increased tendency to follow the newly emerged anti-vaccine party, potentially contributing to their political representation at the national level. These analyses show that the anti-vaccine discourse has expanded and reached a politically representative scale, strengthening its discursive network with conspiracy theories, spirituality, naturalism, and alternative health practices.
Between hope and despair: experiences of precariousness and precarity in the lived experiences of recent diabetic amputees in primary care
Authors: Chew Evelyn A. L. , Lee Mary C. L. , Bartlam Bernadette , Goh Ling Jia , Dong Lijuan , Zhu Xiaoli 
Published: February 2024

AbstractPrecariousness dominates the lives of patients with recent diabetic lower extremity amputations. Wound healing is not guaranteed, post-amputation mortality is high and personal and social identities are destabilised. This study explores the experiences of nine post-amputation diabetic patients in the context of Singapore’s primary health and social care and diversified cultural setting. The loss of physical integrity leads to the self being rendered precarious in multiple ways: emotional-existential precariousness results from uncertainty about survival; agentic precariousness, from restrictions to the individual’s autonomy; the social self is rendered precarious as social relations and identities are changed; and financial precarity, which arises from job insecurity and treatment cost. Patients act to overcome precariousness and regain agency in various ways. Supporting patients’ agency should be integral to all healthcare interventions, at whatever stage of the patient’s journey, and needs to take into account cultural roles and values.
Neurofibromatosis type 1 with three synchronous tumors
Authors: Kakkat Shanavas , Zacharia George Sarin , Ravindran Rohit , Poovan Chothisha , Jacob Anu 
Published: February 2024

AbstractNeurofibromatosis type 1, resulting from dominantly inherited mutations affecting neurofibromin, is among the most common human genetic syndromes associated with many neurocutaneous manifestations. Neoplasms, neurogenic and non-neurogenic, are frequent, as are the gastrointestinal manifestations. Gastrointestinal tumors and vasculopathy are well-reported in individuals with neurofibromatosis type 1. A combination of somatostatioma and gastrointestinal stromal tumor is considered pathognomonic. We here report a case of neurofibromatosis type 1 with a triad of distinct neoplasms: gastrointestinal stromal tumor, neuroendoscrine tumor, and intra-ampullary papillary-tubular neoplasm. The trilogy of these neoplasms is unique and, to our knowledge, has never been reported in the literature. The report also emphasizes the role of advanced immunochemical staining in day-to-day practice, which has improved diagnostic accuracy and yield.
The Precautionary Approach Design Pattern
Authors: Pöysti Tuomas 
Published: February 2024

AbstractThe precautionary approach is a way to manage problems related to the uncertainty of scientific knowledge regarding potential serious harms and to enable decision-making under uncertainty with due diligence. I have developed a model of the essential structural elements of the application of the precautionary approach, particularly the precautionary principle in EU law, as a legal design pattern—a formalized presentation of the core generic features and processes of how the law successfully addresses recurring problems. The precautionary approach appears as a decision tree with weighting and balancing. It serves as an intervening rule to resolve inter-system conflicts between different action systems such as the economy, civil society, and ecological systems. It is related to other design patterns like the proportionality test, risk and impact assessment, and judicial review. Presenting the application of the precautionary approach as a legal design pattern facilitates interdisciplinary communication regarding the essential features of legally required problem-solving. Such a presentation enhances the problem-solving capacity of the application of the law beyond the legal domain, for instance, in improving digitalization efforts and enabling the integration of anticipatory quality controls of justice, legality and good governance into decision-making processes.
A Collections-Based View of the Future of Archaeology
Authors: Domeischel Jenna , Childs S. Terry 
Published: February 2024

AbstractThis theme issue has two primary goals: to illuminate the underdeveloped or faltering areas of the discipline as they relate to archaeological collections and to offer tangible paths forward to address the systemic problems identified as they impact the future of archaeology. Present-day archaeology is complicated due to its many sectors of practice: academia/faculty; cultural resource management; federal, state, and local government; tribal governments and communities; descendant communities; students; the general public; and different types of archaeological repositories. Given this complexity, it can be difficult to identify the expectations (and realities) of each sector, which, if better understood, would help illuminate the nuances of preservation, accountability, discoverability, and use of archaeological collections across the discipline. Without a solid understanding of these nuances, efforts to advance the discipline are undermined. This introduction provides an overview of the articles that address emerging and urgent issues and offer viable steps forward. These challenges include the interrelationships between ethics, collaboration, and training; the preservation and management of digital records and data; collections discovery and reuse; collections-based research; training in material culture; making collections knowable to constituencies outside archaeology; preparing for repatriation from a management perspective; and the intricacies of the archaeological digital data system.
Into the ether or the state? Legibility theory and the cryptocurrency markets
Authors: Kellerman Miles , Seddon Jack 
Published: February 2024

AbstractThere is substantial cross-national variation in the level of regulatory clarity surrounding cryptocurrencies. What explains these differences? And, more broadly, what drives the divergent historical development of market regulation in different jurisdictions? To answer these questions, we present a new conceptual framework centered on the concept of market legibility. This term, inspired by the sociological literature, refers to the extent to which markets are made legible to the state through standardization. We contend that state supply of, and market demand for, legibility drives the primary political-economic dynamics of market regulation. Specifically, these factors combine to produce ideal type states of legibility that correspond to both distinct stages of market development and the relative level of regulatory clarity in any one jurisdiction. This framework is utilized to conduct a comparative historical analysis of cryptocurrency regulation in the EU, US, UK, and Japan. By performing these tasks, this article corrects the common assumption that states are constantly striving to impose their authority on unwilling markets. It demonstrates instead that state and private actor preferences to make markets legible vary, conditioning, in turn, the political economy of regulatory governance.
An assessment of the legal and regulatory framework supporting the implementation of the National Integrated Identity Management System (NIIMS) in Kenya
Authors: Kabata Victor 
Published: February 2024

Abstract
This study sought to establish the elements that constitute comprehensive legal and regulatory landscape for successful digital identity system establishment and implementation. Subsequently, the study sought to assess whether these elements were present in the establishment and implementation of the National Integrated Identity Management System (NIIMS) in Kenya. The study adopted a qualitative approach, data was obtained firstly, through literature review that provided background information to the study. Secondly, semi structured interviews were undertaken on purposively selected key informants. The study established that the elements that constitute a robust legal and regulatory framework for digital identity (ID) establishment and implementation include presence of a constitutional provision on the right to privacy; existence of a digital ID law governing the establishment of the system; amendment of laws relating to the registration of persons; existence of a data protection law; existence of an overarching law governing the digital economy among others. Largely, most of these elements were present in Kenya. However, the legislative approach adopted in crafting digital ID law in Kenya was wanting. This has undermined effective implementation of the NIIM system by among other things eroding public confidence in the system. The study concluded that effective operation of the system hinged on the existence of a robust and comprehensive legal and regulatory framework that will engender users’ trust in the system. In this regard, the study recommended review of the existing legal framework to ensure that it underpins both the foundational and functional aspects of the NIIM system.
Lifting generic points
Authors: DOWNAROWICZ TOMASZ , WEISS BENJAMIN 
Published: February 2024

AbstractLet
$(X,T)$
and
$(Y,S)$
be two topological dynamical systems, where
$(X,T)$
has the weak specification property. Let
$\xi $
be an invariant measure on the product system
$(X\times Y, T\times S)$
with marginals
$\mu $
on X and
$\nu $
on Y, with
$\mu $
ergodic. Let
$y\in Y$
be quasi-generic for
$\nu $
. Then there exists a point
$x\in X$
generic for
$\mu $
such that the pair
$(x,y)$
is quasi-generic for
$\xi $
. This is a generalization of a similar theorem by T. Kamae, in which
$(X,T)$
and
$(Y,S)$
are full shifts on finite alphabets.
Characteristics and suppression of beam distortion in a high repetition rate nanosecond stimulated Brillouin scattering phase conjugation mirror
Authors: Chen Yifu , Tan Bowen , Jin Duo , Chen Bin , Bai Zhenxu , Wang Kun , Wang Yulei , Lü Zhiwei 
Published: February 2024

Abstract
The stimulated Brillouin scattering phase conjugation mirror (SBS-PCM) based on liquid media is widely used in high-power laser systems due to its robust thermal load capacity, high energy conversion efficiency and improved beam quality. Nevertheless, with an increase in the pump repetition rate, thermally-induced blooming and optical breakdown can emerge, leading to distortions in the Stokes beam. In this study, we delved into the thermal effects in liquid SBS-PCMs employing hydrodynamic analysis, establishing a relationship between beam profile distortion and the thermal convection field. We calculated the temperature and convection velocity distribution based on the pump light parameters and recorded the corresponding beam profiles. The intensities of the beam profiles were modulated in alignment with the convection directions, reaching a velocity peak of 2.85 mm/s at a pump pulse repetition rate of 250 Hz. The residual sum of squares (RSS) was employed to quantify the extent of beam profile distortion relative to a Gaussian distribution. The RSS escalated to 7.8, in contrast to 0.7 of the pump light at a pump pulse repetition rate of 500 Hz. By suppressing thermal convection using a high-viscosity medium, we effectively mitigated beam distortion. The RSS was reduced to 0.7 at a pump pulse repetition rate of 500 Hz, coinciding with a twentyfold increase in viscosity, thereby enhancing the beam quality. By integrating hydrodynamic analysis, we elucidated and mitigated distortion with targeted solutions. Our research offers an interdisciplinary perspective on studying thermal effects and contributes to the application of SBS-PCMs in high-repetition-rate laser systems by unveiling the mechanism of photothermal effects.
The beer garden state: Neolocalism and clustering of craft breweries in New Jersey
Authors: Fouad Geoffrey , Scott Robert H. 
Published: February 2024

AbstractThis paper investigates the growth and clustering of craft breweries in New Jersey. We compiled a historical dataset from 1995 to 2020 that allows us to measure the degree of geographic clustering among craft breweries in New Jersey. The number of craft breweries in New Jersey grew 491% from 2012 to 2020 (from 22 to 130 craft breweries). An impetus for this growth was that New Jersey enacted legislation in 2012 that made opening and operating a craft brewery in the state more economically viable. Our analysis finds that craft breweries in New Jersey are clustering in specific parts of the state and that this is likely due to co-location benefits such as building a culture of craft beer that drives innovation, knowledge sharing, customer sharing, and a thicker labor market. While distinct craft beer clusters have formed in New Jersey, we find there is still significant opportunity for growth. Our analysis confirms this using data on planned craft brewery openings to measure changes in the size and density of clusters and where, in New Jersey, new clusters are likely to form.
Spatial standardization of taxon occurrence data—a call to action
Authors: Antell Gawain T. , Benson Roger B. J. , Saupe Erin E. 
Published: February 2024

AbstractThe fossil record is spatiotemporally heterogeneous: taxon occurrence data have patchy spatial distributions, and this patchiness varies through time. Large-scale quantitative paleobiology studies that fail to account for heterogeneous sampling coverage will generate uninformative inferences at best and confidently draw wrong conclusions at worst. Explicitly spatial methods of standardization are necessary for analyses of large-scale fossil datasets, because nonspatial sample standardization, such as diversity rarefaction, is insufficient to reduce the signal of varying spatial coverage through time or between environments and clades. Spatial standardization should control both geographic area and dispersion (spread) of fossil localities. In addition to standardizing the spatial distribution of data, other factors may be standardized, including environmental heterogeneity or the number of publications or field collecting units that report taxon occurrences. Using a case study of published global Paleobiology Database occurrences, we demonstrate strong signals of sampling; without spatial standardization, these sampling signatures could be misattributed to biological processes. We discuss practical issues of implementing spatial standardization via subsampling and present the new R package divvy to improve the accessibility of spatial analysis. The software provides three spatial subsampling approaches, as well as related tools to quantify spatial coverage. After reviewing the theory, practice, and history of equalizing spatial coverage between data comparison groups, we outline priority areas to improve related data collection, analysis, and reporting practices in paleobiology.
THE PROBLEM OF LANGUAGE IN ENNODIUS OF PAVIA
Authors: Hernández Lobato Jesús 
Published: February 2024

AbstractThis paper analyses the metaliterary statements that pervade the oeuvre of Ennodius of Pavia (a.d. 474–521) in order to reconstruct his underlying conception of language: its nature, power, function, limitations, and dangers. This new perspective provides a more nuanced insight into the paradoxical poetics of the author as well as his final renunciation to literature after his appointment as bishop of Pavia.
Lost needle in the oral cavity: can the nightmare be just a bad dream?
Authors: Rodríguez-Alcalá Laura , Valderrama-Penagos Johanna Ximena , O'Connor-Garcia St Ernesto , O'Connor-Reina Carlos 
Published: February 2024

AbstractObjectiveThe loss of a scalpel or a needle during surgery can threaten the health of the patient and lead to additional costs, and radiographical assistance during surgery has been the only recovery method. This study evaluates the efficacy of a metal detector compared with conventional radiology for recovering a needle lost in the oropharynx during surgery.MethodDifferent fragment sizes of needles normally used in pharyngoplasty were embedded at different locations and depths in a lamb's head. Three experienced and three junior otolaryngologists searched for the needle fragments using a metal detector and conventional radiology.ResultsAll fragments were found with each method, but the mean searching time was 90 per cent shorter with the metal detector.ConclusionA metal detector can be a useful tool for locating needles that break during ENT surgery, as it requires less time than conventional radiology and avoids exposing patients to radiation.
Immunization of cattle with a Rhipicephalus microplus chitinase peptide containing predicted B-cell epitopes reduces tick biological fitness
Authors: Perez-Soria María Martina Esperanza , López-Díaz Daniel Gustavo , Jiménez-Ocampo Rafael , Aguilar-Tipacamú Gabriela , Ueti Massaro W. , Mosqueda Juan 
Published: February 2024

AbstractRhipicephalus microplus, the cattle fever tick, is the most important ectoparasite impacting the livestock industry worldwide. Overreliance on chemical treatments for tick control has led to the emergence of acaricide-resistant ticks and environmental contamination. An immunological strategy based on vaccines offers an alternative approach to tick control. To develop novel tick vaccines, it is crucial to identify and evaluate antigens capable of generating protection in cattle. Chitinases are enzymes that degrade older chitin at the time of moulting, therefore allowing interstadial metamorphosis. In this study, 1 R. microplus chitinase was identified and its capacity to reduce fitness in ticks fed on immunized cattle was evaluated. First, the predicted amino acid sequence was determined in 4 isolates and their similarity was analysed by bioinformatics. Four peptides containing predicted B-cell epitopes were designed. The immunogenicity of each peptide was assessed by inoculating 2 cattle, 4 times at 21 days intervals, and the antibody response was verified by indirect ELISA. A challenge experiment was conducted with those peptides that were immunogenic. The chitinase gene was successfully amplified and sequenced, enabling comparison with reference strains. Notably, a 99.32% identity and 99.84% similarity were ascertained among the sequences. Furthermore, native protein recognition was demonstrated through western blot assays. Chitinase peptide 3 reduced the weight and oviposition of engorged ticks, as well as larvae viability, exhibiting a 71% efficacy. Therefore, chitinase 3 emerges as a viable vaccine candidate, holding promise for its integration into a multiantigenic vaccine against R. microplus.
Cross-cultural validation of the revised Green et al., paranoid thoughts scale
Authors: Schlier Björn , Lincoln Tania M. , Kingston Jessica L. , So Suzanne H. , Gaudiano Brandon A. , Morris Eric M. J. , Ellett Lyn 
Published: February 2024

AbstractBackgroundWith efforts increasing worldwide to understand and treat paranoia, there is a pressing need for cross-culturally valid assessments of paranoid beliefs. The recently developed Revised Green et al., Paranoid Thoughts Scale (R-GPTS) constitutes an easy to administer self-report assessment of mild ideas of reference and more severe persecutory thoughts. Moreover, it comes with clinical cut-offs for increased usability in research and clinical practice. With multiple translations of the R-GPTS already available and in use, a formal test of its measurement invariance is now needed.MethodsUsing data from a multinational cross-sectional online survey in the UK, USA, Australia, Germany, and Hong Kong (N = 2510), we performed confirmatory factory analyses on the R-GPTS and tested for measurement invariance across sites.ResultsWe found sufficient fit for the two-factor structure (ideas of reference, persecutory thoughts) of the R-GPTS across cultures. Measurement invariance was found for the persecutory thoughts subscale, indicating that it does measure the same construct across the tested samples in the same way. For ideas of reference, we found no scalar invariance, which was traced back to (mostly higher) item intercepts in the Hong Kong sample.ConclusionWe found sufficient invariance for the persecutory thoughts scale, which is of substantial practical importance, as it is used for the screening of clinical paranoia. A direct comparison of the ideas of reference sum-scores between cultures, however, may lead to an over-estimation of these milder forms of paranoia in some (non-western) cultures.