bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of curcumin nanoparticles in rat liver fibrosis caused by thioacetamide
Authors: Radwan Aliaa M. , Fatoh Shahenda A. , Massoud Ahmed , Tousson Ehab 
Published: October 2023

AbstractAlthough curcumin possesses anti‐inflammatory, antioxidant, and cytoprotective qualities, its low absorption limits its medicinal uses. Before examining how curcumin influenced rats' liver fibrosis when thioacetamide (TAA) was produced, the current study employed nanoparticles (NPs) to improve curcumin bioavailability. Sixty mature rats were separated into six groups (Group 1, control; Group 2, curcumin; Group 3, curcumin nanoparticles; Group 4, TAA; Group 5, TAA + curcumin; Group 6, TAA + curcumin NPs). TAA administration caused considerable increases in serum liver enzymes associated with a remarkable depletion in the levels of albumin and total protein relative to the control. In addition, a significant elevation in malonaldehyde (MDA) level with a significant depletion in the antioxidant enzymes activity was detected. Also, TAA had a significant effect on the inflammation markers represented by the elevation in tumor necrosis factor (TNFα) and DNA damage. Administration of curcumin or curcumin NPs in TAA‐intoxicated rats significantly (p < .001, p < .0001) alleviates liver injury by correcting antioxidant status, inflammatory markers, and oxidative stress. The results of comparing TAA‐intoxicated rats treated with curcumin NPs to TAA‐intoxicated rats treated with bulk curcumin revealed that the ameliorative effect of nanocurcumin was stronger. These observations concluded that nanoparticle formulation can increase curcumin bioavailability and solubility, enhancing its antioxidant and anti‐inflammatory efficiency, resulting in greater potential against thioacetamide‐induced hepatotoxicity in rats.
Accelerated transcranial magnetic stimulation for major depressive disorder: A quick path to relief?
Authors: Tang Nailong , Shu Wanqing , Wang Hua‐ning 
Published: October 2023

AbstractTranscranial magnetic stimulation (TMS) is a safe, tolerable, and evidence‐based intervention for major depressive disorder (MDD). However, even after decades of research, nearly half of the patients with MDD fail to respond to conventional TMS, with responding slowly and requiring daily attendance at the treatment site for 4–6 weeks. To intensify antidepressant efficacy and shorten treatment duration, accelerated TMS protocols, which involve multiple sessions per day over a few days, have been proposed and evaluated for safety and viability. We reviewed and summarized the current knowledge in accelerated TMS, including stimulation parameters, antidepressant efficacy, anti‐suicidal efficacy, safety, and adverse effects. Limitations and suggestions for future directions are also addressed, along with a brief discussion on the application of accelerated TMS during the COVID‐19 pandemic.This article is categorized under:
Neuroscience > Clinical Neuroscience
Intracellular FGF1 protects cells from apoptosis through direct interaction with p53
Authors: Lampart Agata , Krowarsch Daniel , Biadun Martyna , Sorensen Vigdis , Szymczyk Jakub , Sluzalska Katarzyna , Wiedlocha Antoni , Otlewski Jacek , Zakrzewska Malgorzata 
Published: October 2023

AbstractFibroblast growth factor 1 (FGF1) acts by activating specific tyrosine kinase receptors on the cell surface. In addition to this classical mode of action, FGF1 also exhibits intracellular activity. Recently, we found that FGF1 translocated into the cell interior exhibits anti-apoptotic activity independent of receptor activation and downstream signaling. Here, we show that expression of FGF1 increases the survival of cells treated with various apoptosis inducers, but only when wild-type p53 is present. The p53-negative cells were not protected by either ectopically expressed or translocated FGF1. We also confirmed the requirement of p53 for the anti-apoptotic intracellular activity of FGF1 by silencing p53, resulting in loss of the protective effect of FGF1. In contrast, in p53-negative cells, intracellular FGF1 regained its anti-apoptotic properties after transfection with wild-type p53. We also found that FGF1 directly interacts with p53 in cells and that the binding region is located in the DBD domain of p53. We therefore postulate that intracellular FGF1 protects cells from apoptosis by directly interacting with p53.
Kombinierter Einfluss von psychologischen und biomechanischen Faktoren auf die muskulären Belastungen beim Fußballspielen
Authors: Auer Simon , Kubowitsch Simone , Dendorfer Sebastian 
Published: October 2023

ZusammenfassungBeim Zusammenwirken von mentaler Beanspruchung und muskuloskelettaler Belastung steigt das Risiko für Verletzungen durch veränderte Körperkinematik und erhöhte Muskelspannung. Diese Veränderungen können mit muskuloskelettalen Modellen festgestellt werden, wobei zusätzlich die mentale Belastung und Beanspruchung auf emotionaler, kognitiver und verhaltensbezogener Ebene analysiert werden muss. Um diese Kinematik- und Belastungsänderungen unter Stress zu untersuchen, wurden Leistungssportler:innen bei hochdynamischen Bewegungen mentalem Stress ausgesetzt und mittels muskuloskelettaler Modelle die biomechanische Belastung analysiert. Dabei zeigte sich, dass es unter mentaler Beanspruchung, unabhängig vom subjektiven Empfinden, zu einer starken Änderung der Muskelkräfte kommen kann. Entsprechend sollten Leistungssportler:innen Screenings zur Beurteilung der individuellen Bewegungsmuster durchlaufen und die allgemeine Stressresilienz gefördert werden.
Physiological and genetic regulation of anhydrobiosis in yeast cells
Authors: Sęk Wioletta , Kot Anna M. , Rapoport Alexander , Kieliszek Marek 
Published: October 2023

AbstractAnhydrobiosis is a state of living organisms during which their metabolism is reversibly delayed or suspended due to a high degree of dehydration. Yeast cells, which are widely used in the food industry, may be induced into this state. The degree of viability of yeast cells undergoing the drying process also depends on rehydration. In an attempt to explain the essence of the state of anhydrobiosis and clarify the mechanisms responsible for its course, scientists have described various cellular compounds and structures that are responsible for it. The structures discussed in this work include the cell wall and plasma membrane, vacuoles, mitochondria, and lysosomes, among others, while the most important compounds include trehalose, glycogen, glutathione, and lipid droplets. Various proteins (Stf2p; Sip18p; Hsp12p and Hsp70p) and genes (STF2; Nsip18; TRX2; TPS1 and TPS2) are also responsible for the process of anhydrobiosis. Each factor has a specific function and is irreplaceable, detailed information is presented in this overview.
Graphical abstract
Channel-assisted cervical key hole technology combined with ultrasonic bone osteotome versus posterior percutaneous endoscopic cervical foraminotomy: a clinical retrospective study
Authors: Sun Xiao , Wang Chuanen , Kong Qingquan , Zhang Bin , Feng Pin , Liu Junlin , Hu Yuan , Ma Junsong , Xiang Junwei 
Published: October 2023

Abstract
Purpose
The search for more effective and safe treatment methods for cervical spondylotic radiculopathy (CSR) has led to the rapid development and increasing popularity of minimally invasive posterior cervical foraminotomy (MI-PCF). This study aims to compare two important approaches for MI-PCF surgery: the channel-assisted cervical key hole technology combined with ultrasonic bone osteotome (CKH-UBO) and posterior percutaneous endoscopic cervical foraminotomy (PPECF).

Methods
Data from patients treated with single-level CKH-UBO (n = 35) or PPECF (n = 40) were analyzed. Clinical outcomes, including visual analogue scale (VAS) scores for neck and arm pain, Neck Disability Index (NDI), and modified Macnab criteria, were assessed preoperatively, as well as at three days, three months, and one year postoperatively.

Results
The percentages of patients with excellent and good outcomes were 97.14% and 92.5%, respectively. The average surgical time in the CKH-UBO group was significantly shorter than in the PPECF group (p < 0.001), while the average incision length in the PPECF group was significantly smaller than in the CKH-UBO group. There were no significant differences between the two groups in terms of blood loss, hospital stay, and clinical outcomes at three days, three months, and 12 months postoperatively.

Conclusion
CKH-UBO can achieve the same surgical outcomes as PPECF for the treatment of CSR. However, CKH-UBO saves more time but requires patients to undergo larger incisions.
Superomedial-Posterior Pedicle-Based Reduction Mammaplasty: Evaluation of Effectiveness and BREAST-Q Outcomes of a Rapid and Safer Technique
Authors: La Padula Simone , Mernier Thibaud , Larcher Quentin , Pizza Chiara , D’Andrea Francesco , Pensato Rosita , Meningaud Jean Paul , Hersant Barbara 
Published: October 2023

Abstract
Introduction
Breast hypertrophy, a common pathological condition, often requires surgical intervention to alleviate musculoskeletal pain and improve patients’ quality of life. Various techniques have been developed for breast reduction, each with its own advantages and complications. The primary aim of this study is to evaluate the efficacy, safety, and patient-reported outcomes of the authors technique: the Superomedial-Posterior Pedicle-Based Reduction Mammaplasty.

Material and Methods
A prospective study was conducted on 912 patients who underwent breast reduction surgery between November 2012 and July 2020. The surgical technique involved preserving all glandular tissue from the areola to the pectoralis major muscle using the superomedial-posterior pedicle. The patients’ demographic data, operative details, complications, breast-related quality of life (measured using the Breast-Q questionnaire), and nipple–areola complex sensitivity were analyzed.

Results
The average operative time was 62.12 ± 10.3 minutes. Complications included minor wound dehiscence (4.05%) and hematoma (1.2%), with no cases of nipple–areola complex necrosis. Nipple–areola sensitivity was fully restored in all patients at the 2-year follow-up. Patient satisfaction with the procedure was high with a statistically significant difference observed between pre- and postoperative scores (p < 0.001) of the Breast-Q questionnaire.

Conclusion
Authors technique offers reliable vascularization and innervation of the nipple–areola complex and achieves satisfactory aesthetic outcomes. It is associated with shorter operative times compared to other techniques reported in the literature. The Superomedial-Posterior Pedicle-Based Reduction Mammaplasty represents a safe and effective method for breast reduction surgery, providing significant benefits to patients with breast hypertrophy.

Level of Evidence I
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis
Authors: Scholda Julia , Nguyen Thi Thuy Anh , Kopp Florian 
Published: October 2023

AbstractNormal cell and body functions need to be maintained and protected against endogenous and exogenous stress conditions. Different cellular stress response pathways have evolved that are utilized by mammalian cells to recognize, process and overcome numerous stress stimuli in order to maintain homeostasis and to prevent pathophysiological processes. Although these stress response pathways appear to be quite different on a molecular level, they all have in common that they integrate various stress inputs, translate them into an appropriate stress response and eventually resolve the stress by either restoring homeostasis or inducing cell death. It has become increasingly appreciated that non-protein-coding RNA species, such as long noncoding RNAs (lncRNAs), can play critical roles in the mammalian stress response. However, the precise molecular functions and underlying modes of action for many of the stress-related lncRNAs remain poorly understood. In this review, we aim to provide a framework for the categorization of mammalian lncRNAs in stress response and homeostasis based on their experimentally validated modes of action. We describe the molecular functions and physiological roles of selected lncRNAs and develop a concept of how lncRNAs can contribute as versatile players in mammalian stress response and homeostasis. These concepts may be used as a starting point for the identification of novel lncRNAs and lncRNA functions not only in the context of stress, but also in normal physiology and disease.
Heat stress in South America over the last four decades: a bioclimatic analysis
Authors: Miranda Vitor F. V. V. , dos Santos Djacinto Monteiro , Peres Leonardo F. , Salvador Coral , Nieto Raquel , Müller Gabriela V. , Thielen Dirk , Libonati Renata 
Published: October 2023

AbstractThe observed continuous rise in the frequency of extreme heat events in South America (SA) poses a serious challenge for public health. However, there is a lack on the understanding of the large-scale and long-term variability and trends of thermal stress in this continent. Accordingly, here we developed the first comprehensive bioclimatology of thermal stress over SA during the past four decades. Consecutive heat stress hours were analyzed using the Universal Thermal Climate Index (UTCI) from ERA5-HEAT reanalysis according to the Köppen–Geiger climate classification and also focusing on the 31 most populated cities of SA. Results show an inland/coastline contrast and a marked latitudinal northward increase in the number of hours under heat stress. Heat stress hotspots are located mostly around the Amazon, northern and central parts of SA with 26–35% of the hours between 1979 and 2020 under strong heat stress. The annual number of hours within heat stress increased significantly between 1979 and 2020, varying from + 1.16 h/year to + 8.25 h/year depending on the Köppen–Geiger class. The past 20 years (2000 forward) presented not only more consecutive hours under heat stress than the previous two decades in all the analyzed cities, but also a higher persistence of such conditions. The bioclimatology of thermal stress developed here may provide important guidelines to decision-makers for exploring adaptation strategies to increase societal resilience.
Sexual dysfunction in a sample of Egyptian patients with Parkinson’s disease
Authors: Deraz Heba Assem Deraz Abdelhalim , Amer Hanan Abdalla Hassan , Suleiman Muhammad Ramadan , Dahshan Ahmed 
Published: October 2023

Abstract
Background
Sexual dysfunction (SD) is a common, yet underdiagnosed problem in Parkinson Disease (PD) patients. It can negatively impact their quality of life (QoL) and clinical outcome. we tried to assess SD in a group of Egyptian PD patients.

Methods
The study is a case–control, cross-sectional study that included 200 participants, consisting of 100 PD patients and 100 matched healthy controls. Social, demographic information, and clinical variables were collected from both groups. Sexual functions were assessed using the Arabic Female Sexual Function Index (ArFSFI), and the Arabic version of International Index of Erectile Function (IIEF).

Results
Women with PD scored worse on FSFI total score compared to controls (p < 0.001). Regarding the FSFI domains, they scored significantly lower in individual domains of desire (p < 0.001), arousal (p < 0.001), lubrication (p = 0.006), orgasm (p < 0.001), satisfaction (p < 0.001), and pain (p = 0.003), compared with controls. Men with PD scored worse on IIEF total scores compared to controls (p < 0.001). They showed significantly worse scores of erectile functions (p < 0.001), orgasmic function (p < 0.001), sexual desire (p < 0.001), intercourse satisfaction (p < 0.001), and overall satisfaction (p < 0.001). Both groups reported significant effect of SD on their QoL. There was a significant correlation between disease severity and SD.

Conclusion
SD is common in PD patients. It negatively impacts their QoL and partnership. Healthcare professionals should initiate conversations about SD with the patients and provide appropriate education and treatment options.
The Impact of Digital and Analog Approaches on a Multidimensional Preschool Science Education
Authors: Otterborn Anna , Sundberg Bodil , Schönborn Konrad 
Published: October 2023

AbstractSwedish preschool science practice is confined to a unique educational setting where upbringing, care, and education are intertwined. This allows teachers to develop innovative cross-curricular and multidimensional science teaching. At the same time, society demands the digitalization of preschool practice, which has caused concern not only about negative effects on children’s well-being but also the risk of foregrounding digital over analog tools in multidimensional and child-centered preschool practice. The aim of this study is to analyze how preschool teachers at the forefront of digitalization integrate digital and analog tools when teaching science and how this integration affects their practice. The data comprises documentation of digitalized science activities provided by ten preschool teachers and transcribed recall interviews with four of the teachers. Thematic content analysis and a framework for analyzing seven teaching dimensions of preschool science revealed the use of digital and analog tools as drivers for multidimensional science education. The findings show that the teachers primarily use digital tools to reinforce social learning, inclusion, and agency during science activities. Digital and analog tools were used to complement one another in pursuing the boundaries of multidimensional science. However, the content of this innovative and digitalized science teaching remained primarily within biology, the traditional scholarly discipline in preschool science. We conclude that the digitalization of preschool science seems to be used to strengthen and diversify teaching within the boundaries of overarching traditional preschool practice where nature encounters and children’s interests and well-being are at the forefront.
Mass transfer vectors for nitric oxide removal through biological treatments
Authors: Páez David Fernando Cubides , Villalba Xavier Guimerà , Zabalo Nerea Abasolo , Galceran Helena Torrell , Güell Irene Jubany , Noguera Xavier Gamisans 
Published: October 2023

AbstractThe reduction of nitric oxide (NO) emissions to atmosphere has been recently addressed using biological technologies. However, NO removal through bioprocesses is quite challenging due to the low solubility of NO in water. Therefore, the abatement of NO emissions might be improved by adding a chelating agent or a mass transfer vector (MTV) to increase the solubility of this pollutant into the aqueous phase where the bioprocess takes place. This research seeks to assess the performance of different non-aqueous phase liquids (NAPs): n-hexadecane (HEX), diethyl sebacate (DSE), 1,1,1,3,5,5,5-heptamethyl-trisiloxane (HTX), 2,2,4,4,6,8,8-heptamethylnonane (HNO), and high temperature silicone oil (SO) in chemical absorption–biological reduction (CABR) integrated systems. The results showed that HNO and HTX had the maximum gas-liquid mass transfer capacity, being 0.32 mol NO/kmol NAP and 0.29 mol NO/kmol NAP, respectively. When an aqueous phase was added to the system, the mass transfer gas–liquid of NO was increased, with HTX reaching a removal efficiency of 82 ± 3% NO with water, and 88 ± 6% with a phosphate buffer solution. All NAPs were tested for short-term toxicity assessment and resulted neither toxic nor inhibitory for the biological activity (denitrification). DSE was found to be biodegradable, which could limit its applicability in biological processes for gas treatment. Finally, in the CABR system tests, it was shown that NO elimination improved in a short time (30 min) when the three mass transfer vectors (HEX, HTX, HNO) were added to enriched denitrifying bacteria.
Effect of Sn Concentration on the Structural and Thermal Properties of SnxSb20Se80−x Glasses
Authors: Khalifa Zaki S. , Mohamed S. H. 
Published: October 2023

AbstractSnxSb20Se80−x bulk glasses were prepared using the well-known melt quenching technique, where x was taken as 7.5 at.%, 9.5 at.%, 11.5 at.% and 13 at.%. X-ray diffraction (XRD) and differential scanning calorimetery (DSC) were used to monitor the crystallinity and transition temperatures, respectively. XRD examinations showed that the 7.5 at.% and 9.5 at.% compositions were purely amorphous, while the other two compositions exhibited a crystalline structure. DSC thermograms demonstrated that 7.5 at.% and 9.5 at.% alloys had a single crystallization peak, whereas for the 11.5 at.% and 13 at.% alloys, two exothermic peaks and three peaks appeared. The glass stability and kinetics of amorphization and crystallization were studied using different approaches. The correlation between topological constraints and the dimensionality of the growth was established.
Diabetes Remission After LRYGBP With and Without Fundus Resection: a Randomized Clinical Trial
Authors: Kehagias Dimitrios , Lampropoulos Charalampos , Georgopoulos Neoklis , Habeos Ioannis , Kalavrizioti Dimitra , Vamvakas Sotirios-Spyridon , Davoulou Panagiota , Kehagias Ioannis 
Published: October 2023

Abstract
Background
Glycemic control, after metabolic surgery, is achieved in two stages, initially with neuroendocrine alterations and in the long-term with sustainable weight loss. The resection of the gastric fundus, as the major site of ghrelin production, is probably related with optimized glucose regulation. The aim of the present study is to investigate whether the modification of laparoscopic Roux-en-Y gastric bypass (LRYGBP) with fundus resection offers superior glycemic control, compared to typical LRYGBP.

Materials and Methods
Participants were 24 patients with body mass index (BMI) ≥40kg/m2 and type II diabetes mellitus (T2DM), who were randomly assigned to undergo LRYGBP and LRYGBP with fundus resection (LRYGBP+FR). Gastrointestinal (GI) hormones [ghrelin, glucagon-like-peptide-1 (GLP-1), peptide-YY (PYY)] and glycemic parameters (glucose, insulin, HbA1c, C-peptide, insulinogenic index, HOMA-IR) were measured preoperatively, at 6 and 12 months during an oral glucose tolerance test (OGTT).

Results
Ninety-five percent of patients showed complete remission of T2DM after 12 months. LRYGBP+FR was not related with improved glycemic control, compared to LRYGBP. Ghrelin levels were not significantly reduced at 6 and 12 months after LRYGBP+FR. GLP-1 and PYY levels were remarkably increased postprandially in both groups at 6 and 12 months postoperatively (p<0.01). Patients who underwent LRYGBP+FR achieved a significantly lower BMI at 12 months in comparison to LRYGBP (p<0.05).

Conclusion
Fundus resection is not associated with improved glycemic regulation, compared to typical LRYGBP and the significant decrease in BMI after LRYGBP+FR has to be further confirmed with longer follow-up.

Graphical Abstract