bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis
Authors: Wang Mengfei , Kono Masaya , Yamaguchi Yusaku , Islam Jahidul , Shoji Sunao , Kitagawa Yuichi , Fushimi Koji , Watanabe Sora , Matsuba Go , Yamamoto Akihisa , Tanaka Motomu , Tsuda Masumi , Tanaka Shinya , Hasegawa Yasuchika 
Published: January 2024

AbstractAccurate determination of human tumor malignancy is important for choosing efficient and safe therapies. Bioimaging technologies based on luminescent molecules are widely used to localize and distinguish active tumor cells. Here, we report a human cancer grade probing system (GPS) using a water-soluble and structure-changeable Eu(III) complex for the continuous detection of early human brain tumors of different malignancy grades. Time-dependent emission spectra of the Eu(III) complexes in various types of tumor cells were recorded. The radiative rate constants (kr), which depend on the geometry of the Eu(III) complex, were calculated from the emission spectra. The tendency of the kr values to vary depended on the tumor cells at different malignancy grades. Between T = 0 and T = 3 h of invasion, the kr values exhibited an increase of 4% in NHA/TS (benign grade II gliomas), 7% in NHA/TSR (malignant grade III gliomas), and 27% in NHA/TSRA (malignant grade IV gliomas). Tumor cells with high-grade malignancy exhibited a rapid upward trend in kr values. The cancer GPS employs Eu(III) emissions to provide a new diagnostic method for determining human brain tumor malignancy.
Influence of changes in foot morphology and temperature on bruised toenail injury risk during running
Authors: Song Yang , Cen Xuanzhen , Sun Dong , Bíró István , Mao Zhuqing , Fang Yufei , Gu Yaodong 
Published: January 2024

AbstractDespite runners frequently suffering from dermatologic issues during long distance running, there is no compelling evidence quantitatively investigating their underlying injury mechanism. This study aimed to determine the foot morphology and temperature changes during long distance running and reveal the effect of these alterations on the injury risk of bruised toenail by measuring the subjective-perceived hallux comfort and gap length between the hallux and toebox of the shoe. Ten recreational runners participated in the experimental tests before (baseline), immediately after 5 and 10 km of treadmill running (12 km/h), in which the foot morphology was measured by a 3D foot scanner, the foot temperature was detected by an infrared camera, the perceived comfort was recorded by a visual analogue scale, and the gap length in the sagittal plane was captured by a high-speed camera. Ball width became narrower (106.39 ± 6.55 mm) and arch height (12.20 ± 2.34 mm) was reduced greatly after the 10 km run (p < 0.05). Foot temperature increased significantly after 5 and 10 km of running, and the temperature of dorsal hallux (35.12 ± 1.46 °C), dorsal metatarsal (35.92 ± 1.59 °C), and medial plantar metatarsal (37.26 ± 1.34 °C) regions continued to increase greatly from 5 to 10 km of running (p < 0.05). Regarding hallux comfort, the perceived scores significantly reduced after 5 and 10 km of running (2.10 ± 0.99,p < 0.05). In addition, during one running gait cycle, there was a significant increase in gap length at initial contact (39.56 ± 6.45 mm,p < 0.05) for a 10 km run, followed by a notable decrease upon reaching midstance (29.28 ± 6.81 mm,p < 0.05). It is concluded that the reduced ball width and arch height while increased foot temperature during long-distance running would exacerbate foot-shoe interaction, potentially responsible for bruised toenail injuries.
A comprehensive study for selecting optimal treatment modalities for blood cancer in a Fermatean fuzzy dynamic environment
Authors: Alghazzawi Dilshad , Noor Aqsa , Alolaiyan Hanan , El-Wahed Khalifa Hamiden Abd , Alburaikan Alhanouf , Dai Songsong , Razaq Abdul 
Published: January 2024

AbstractCancer is characterized by uncontrolled cell proliferation, leading to cellular damage or death. Acute lymphoblastic leukemia (ALL), a kind of blood cancer, that affects lymphoid cells and is a challenging malignancy to treat. The Fermatean fuzzy set (FFS) theory is highly effective at capturing imprecision due to its capacity to incorporate extensive problem descriptions that are unclear and periodic. Within the framework of this study, two innovative aggregation operators: The Fermatean fuzzy Dynamic Weighted Averaging (FFDWA) operator and the Fermatean fuzzy Dynamic Weighted Geometric (FFDWG) operator are presented. The important attributes of these operators, providing a comprehensive elucidation of their significant special cases has been discussed in details. Moreover, these operators are utilized in the development of a systematic approach for addressing scenarios involving multiple attribute decision-making (MADM) problems with Fermatean fuzzy (FF) data. A numerical example concerning on finding the optimal treatment approach for ALL using the proposed operators, is provided. At the end, the validity and merits of the new method to illustrate by comparing it with the existing methods.
Serum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer
Authors: Huang Bin-Liang , Wei Lai-Feng , Lin Yi-Wei , Huang Li-Sheng , Qu Qi-Qi , Li Xin-Hao , Chu Ling-Yu , Xu Yi-Wei , Wang Wei-Dong , Peng Yu-Hui , Wu Fang-Cai 
Published: January 2024

AbstractOur previous study showed that levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) has potential diagnostic value for early-stage upper gastrointestinal cancers. This study aimed to assess whether serum IGFBP-1 is a potential diagnostic and prognostic biomarker for CRC patients. IGFBP-1 mRNA expression profile data of peripheral blood in colorectal cancer (CRC) patients were downloaded and analyzed from Gene Expression Omnibus database. We detected serum IGFBP-1 in 138 CRC patients and 190 normal controls using enzyme-linked immunosorbent assay. Blood IGFBP-1 mRNA levels were higher in CRC patients than those in normal controls (P = 0.027). In addition, serum IGFBP-1 protein levels in the CRC group were significantly higher than those in normal control group (P < 0.0001). Serum IGFBP-1 demonstrated better diagnostic accuracy for all CRC and early-stage CRC, respectively, when compared with carcinoembryonic antigen (CEA), carbohydrate antigen19-9 (CA 19-9) or the combination of CEA and CA19-9. Furthermore, Cox multivariate analysis revealed that serum IGFBP-1 was an independent prognostic factor for OS (HR = 2.043, P = 0.045). Our study demonstrated that serum IGFBP-1 might be a potential biomarker for the diagnosis and prognosis of CRC. In addition, the nomogram might be helpful to predict the prognosis of CRC.
Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function
Authors: Saha Piyali , Weigle Ian Q. , Slimmon Nicholas , Poli Pedro Blauth , Patel Priyam , Zhang Xiaoqiong , Cao Yajun , Michalkiewicz Julia , Gomm Ashley , Zhang Can , Tanzi Rudolph E. , Dylla Nicholas , Al-Hendy Ayman , Sisodia Sangram S. 
Published: January 2024

AbstractIt is well-established that women are disproportionately affected by Alzheimer’s disease. The mechanisms underlying this sex-specific disparity are not fully understood, but several factors that are often associated-including interactions of sex hormones, genetic factors, and the gut microbiome-likely contribute to the disease's etiology. Here, we have examined the role of sex hormones and the gut microbiome in mediating Aβ amyloidosis and neuroinflammation in APPPS1-21 mice. We report that postnatal gut microbiome perturbation in female APPPS1-21 mice leads to an elevation in levels of circulating estradiol. Early stage ovariectomy (OVX) leads to a reduction of plasma estradiol that is correlated with a significant alteration of gut microbiome composition and reduction in Aβ pathology. On the other hand, supplementation of OVX-treated animals with estradiol restores Aβ burden and influences gut microbiome composition. The reduction of Aβ pathology with OVX is paralleled by diminished levels of plaque-associated microglia that acquire a neurodegenerative phenotype (MGnD-type) while estradiol supplementation of OVX-treated animals leads to a restoration of activated microglia around plaques. In summary, our investigation elucidates the complex interplay between sex-specific hormonal modulations, gut microbiome dynamics, metabolic perturbations, and microglial functionality in the pathogenesis of Alzheimer's disease.
Weaning causes imbalanced T lymphocyte distribution and impaired intestinal immune barrier function in piglets
Authors: Dong Li , Wang Mengxuan , Peng Zhong , Li Hongmin , Wang Hongrong , Qin Tao , Yin Yinyan , Yu Lihuai 
Published: January 2024

Context The immune system of piglets is not fully developed at weaning. The immature adaptive immune system along with the change in the feed types and the living conditions make piglets susceptible to pathogenic infections, and result in diarrhoea and decreased growth. However, the underlying mechanisms require further research. Aims This study was conducted to investigate the effects of weaning on the growth performance and intestinal immune function of piglets. Methods In total, 40 piglets with similar bodyweights were selected in pairs at 21 days old and divided into the suckling group (SG, breastfed by their mothers) and weaning group (WG, weaned at 21 days old). Eight piglets from each group were randomly selected and sacrificed at 24 days (SG3 and WG3) and 28 days of age (SG7 and WG7). The growth performance, T lymphocyte subpopulations, the concentration of cytokines and immunoglobulins, and the expression of Notch2 signalling proteins were determined. Key results The weaning caused a decrease in bodyweight (P < 0.01) and the ratio of CD3+CD4+/CD3+CD8+ T cells in the thymus (P < 0.05). Compared with SG3, the concentration of secretory immunoglobulin A (sIgA) in the jejunum was decreased, and that of interleukin 2 (IL-2) in serum and ileum, IL-1β and IL-2 in jejunum were upregulated (P < 0.01), while IL-10 in the small intestine was downregulated (P < 0.05) in WG3. Weaning downregulated gene expression of IL-4 and upregulated gene expression of IL-1β, IL-12, and interferon γ (IFN-γ) in small intestine (P < 0.05). Weaning downregulated protein expression of Notch2 and Hes1 but upregulated Jagged1 expression in small intestine of piglets (P < 0.05). Conclusions Weaning caused an imbalance in T lymphocyte distribution, thus impairing the intestinal immune function of piglets, which might be associated with the Notch2 signalling. Furthermore, weaning caused adverse effects on piglets especially on the first 3 days, which were partly recovered after 3 days, but still existed at 7 days after weaning. Implications The results of this study may guide the pig-raising industry, especially for the management of piglets shortly after weaning.
Influence of samarium on the structural, magnetic, and gas sensing performance of cadmium zinc ferrites
Authors: Korek Hani , Habanjar Khulud , Awad R 
Published: January 2024

Abstract
Cadmium zinc ferrites Cd0.5Zn0.5SmxFe2−xO4 nanoparticles were synthesized with different concentrations x = 0.00, 0.01, 0.02, 0.04, 0.06, and 0.08, via the wet chemical co-precipitation method. The effects of the Sm3+ doping on the structural, morphological, compositional, and magnetic properties have been investigated. The structural analysis is performed using x-ray diffraction (XRD) with Rietveld refinement. The results indicate great crystallinity in the FCC Fd3m spinel structure of Cd0.5Zn0.5SmxFe2−xO4 nanoparticles. The crystallite size was estimated using Debye–Scherrer, Williamson–Hall, Size-strain plot (SSP), and Halder-Wagner (H-W) methods. It revealed a decreasing trend with the increase of Sm-doping concentrations until the solubility limit at around x = 0.04. The spherical morphology of the samples was investigated using transmission electron microscopy (TEM) with minor agglomeration as a benefit of using the capping agent polyvinylpyrrolidone (PVP). Raman spectroscopy validates the incorporation of trivalent Sm3+ in the octahedral sites. X-ray photoelectron spectroscopy (XPS) verified the elemental compositions as well as the purity of the samples and the incorporation of the dopants. A vibrating sample magnetometer (VSM) was used to study the magnetic properties, and which indicates the superparamagnetic behavior of the prepared samples. The prepared samples were tested as liquefied petroleum gas (LPG) sensors by studying their sensitivity, optimum working temperature, response time, and recovery time. The doping of samarium ions reveals a great increase in LPG sensing sensitivity and optimum temperature with decreasing response and recovery times.
Normally-off recessed gate β-Ga2O3 MOSHFETs with a modulation-doped heterostructure back-barrier
Authors: Atmaca Gökhan , Cha Ho-Young 
Published: January 2024

Abstract
This study demonstrates enhancement-mode recessed-gate β-Ga2O3 metal–oxide–semiconductor heterojunction field-effect transistors (MOSHFETs) with a combination of the MOS channel and a modulation-doped heterostructure to improve maximum drain current and on-resistance (RON). In this proposed device concept, modulation doping in the heterostructure back-barrier inserted into the MOS channel increases the electron density in the MOS channel while maintaining a normally-off operation. First, 2D simulations of enhancement-mode recessed-gate β-Ga2O3 metal–oxide–semiconductor field-effect transistors (MOSFETs) were performed in a Silvaco ATLAS TCAD environment to calibrate the transfer characteristics with the measured data of the investigated device reported previously. Second, using calibrated physical models and parameters, the transfer and transconductance characteristics, and output and off-state characteristics of the enhancement-mode recessed-gate β-Ga2O3 MOSHFETs were comprehensively investigated. The maximum drain current at VGS = 8 V and VDS = 10 V could be increased up to 32.6 mA mm−1 from 9.1 mA mm−1 with the MOSHFET in comparison with that of the recessed-gate MOSFET. The breakdown voltage increased considerably from 186 V to 226 V for the recessed-gate MOSHFET. The proposed device also showed a lower RON, which decreased from 354 Ω.mm to 214 Ω.mm owing to greater electron accumulation in the channel owing to the introduction of the modulation-doped heterostructure.
Reform of the Arbitration Act 1996: a missed opportunity to entrench diversity?
Authors: Davies Ella , Noury Sylvia 
Published: January 2024

Abstract
This article discusses the recent consultation by the Law Commission of England and Wales (‘Law Commission’) on reform to the Arbitration Act 1996 (‘AA 1996’) which grappled with the issue of discrimination in agreements to appoint arbitrators. Recent efforts by the arbitration community to promote greater arbitrator diversity have started to result in the codification of equality and diversity considerations directly into some arbitral rules. However, guidelines developed to date by arbitral institutions have tended to focus on promoting greater diversity in institutional appointments rather than prohibiting discrimination in party appointments. In its September 2022 Consultation Paper, the Law Commission initially proposed new statutory provisions which would have made agreements relating to arbitrators’ ‘protected characteristics’ unenforceable, subject to certain exceptions. This article discusses some areas of uncertainty with these proposals which ultimately led to their abandonment, as well as the Law Commission’s conclusion against reforming the AA 1996 to prohibit discrimination in arbitration generally. The article examines some of the alternative ways in which discrimination could have been addressed through statutory reform and whether it is desirable for the onus to fall back to the arbitral institutions to adopt more robust guidance prohibiting discrimination in party appointments.
The Use of Hyaluronidase in Aesthetic Practice: A Comparative Study of Practitioner Usage in Elective and Emergency Situations
Authors: Currie Elena , Granata Bronwyn , Goodman Greg , Rudd Alice , Wallace Katy , Rivkin Alexander , Hart Sarah , Porter Catherine E , Harris Steven , Walker Lee , Lin Frank , Corduff Niamh , Davies Nik , Roberts Stefania , Clague Michael , Callan Peter P , McDonald Cara , Magnusson Mark , Tsirbas Angelo , Gupta Ritu , Bekhor Philip , Welsh Belinda 
Published: January 2024

Abstract

Background
Hyaluronic acids (HAs) continue to be the fillers of choice worldwide and their popularity is growing. Adverse events (AEs) are able to be resolved through the use of hyaluronidase (HYAL). However, routine HYAL use has been at issue due to perceived safety issues.

Objectives
There are currently no guidelines on the use of HYAL in aesthetic practice, leading to variability in storage, preparation, skin testing, and beliefs concerning AEs. This manuscript interrogated the use of this agent in daily practice.

Methods
A 39-question survey concerning HYAL practice was completed by 264 healthcare practitioners: 244 from interrogated databases and 20 from the consensus panel. Answers from those in the database were compared to those of the consensus panel.

Results
Compared to the database group, the consensus group was more confident in the preparation of HYAL, kept reconstituted HYAL for longer, and was less likely to skin test for HYAL sensitivity and more likely to treat with HYAL in an emergency, even in those with a wasp or bee sting anaphylactic history. Ninety-two percent of all respondents had never observed an acute reaction to HYAL. Just over 1% of respondents had ever observed anaphylaxis. Five percent of practitioners reported longer-term adverse effects, including 3 respondents who reported loss of deep tissues. Consent before injecting HA for the possible requirement of HYAL was always obtained by 74% of practitioners.

Conclusions
Hyaluronidase would appear to be an essential agent for anyone injecting hyaluronic acid filler. However, there is an absence of evidence-based recommendations with respect to the concentration, dosing, and treatment intervals of HYAL, and these should ideally be available.

Level of Evidence: 5
Broadening horizons: ferroptosis as a new target for traumatic brain injury
Authors: Wei Ziqing , Yu Haihan , Zhao Huijuan , Wei Mingze , Xing Han , Pei Jinyan , Yang Yang , Ren Kaidi 
Published: January 2024

Abstract
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with ~50 million people experiencing TBI each year. Ferroptosis, a form of regulated cell death triggered by iron ion-catalyzed and reactive oxygen species-induced lipid peroxidation, has been identified as a potential contributor to traumatic central nervous system conditions, suggesting its involvement in the pathogenesis of TBI. Alterations in iron metabolism play a crucial role in secondary injury following TBI. This study aimed to explore the role of ferroptosis in TBI, focusing on iron metabolism disorders, lipid metabolism disorders and the regulatory axis of system Xc−/glutathione/glutathione peroxidase 4 in TBI. Additionally, we examined the involvement of ferroptosis in the chronic TBI stage. Based on these findings, we discuss potential therapeutic interventions targeting ferroptosis after TBI. In conclusion, this review provides novel insights into the pathology of TBI and proposes potential therapeutic targets.
Iatrogenic bioprosthetic, self-expandable, transcatheter aortic valve replacement dysfunction after cardiac catheterization
Authors: Amirian Aslan , Goda Hemal , Mansoor Atizazul 
Published: January 2024

Abstract
Bioprosthetic valve dysfunction (BVD) is typically a progressive process related to natural wear of the prosthesis. With acute presentations, possible durability issues or iatrogenic causes need to be considered. Here, we present 2 patients with acute BVD of self-expanding, transcatheter aortic valve replacement post-heart catheterization. The presentations and outcomes, in otherwise normally functioning valves antecedent to the heart catheterizations, raise the question of the increased complexity of coronary access in this valve platform, and whether that or other features provide for greater risk of such events. We believe this to be the first publication of such events and they help to highlight the importance of valve implantation planning, as well as familiarity with the potential complexity of coronary access during heart catheterization.
Ciliopathy due to POC1A deficiency: clinical and metabolic features, and cellular modeling
Authors: Perge Kevin , Capel Emilie , Villanueva Carine , Gautheron Jérémie , Diallo Safiatou , Auclair Martine , Rondeau Sophie , Morichon Romain , Brioude Frédéric , Jéru Isabelle , Rossi Massimiliamo , Nicolino Marc , Vigouroux Corinne 
Published: January 2024

Abstract

Objective
SOFT syndrome (MIM#614813), denoting Short stature, Onychodysplasia, Facial dysmorphism, and hypoTrichosis, is a rare primordial dwarfism syndrome caused by biallelic variants in POC1A, encoding a centriolar protein. SOFT syndrome, characterized by severe growth failure of prenatal onset and dysmorphic features, was recently associated with insulin resistance. This study aims to further explore its endocrinological features and pathophysiological mechanisms.

Design/Methods
We present clinical, biochemical, and genetic features of 2 unrelated patients carrying biallelic pathogenic POC1A variants. Cellular models of the disease were generated using patients' fibroblasts and POC1A-deleted human adipose stem cells.

Results
Both patients present with clinical features of SOFT syndrome, along with hyperinsulinemia, diabetes or glucose intolerance, hypertriglyceridemia, liver steatosis, and central fat distribution. They also display resistance to the effects of IGF-1. Cellular studies show that the lack of POC1A protein expression impairs ciliogenesis and adipocyte differentiation, induces cellular senescence, and leads to resistance to insulin and IGF-1. An altered subcellular localization of insulin receptors and, to a lesser extent, IGF1 receptors could also contribute to resistance to insulin and IGF1.

Conclusions
Severe growth retardation, IGF-1 resistance, and centripetal fat repartition associated with insulin resistance-related metabolic abnormalities should be considered as typical features of SOFT syndrome caused by biallelic POC1A null variants. Adipocyte dysfunction and cellular senescence likely contribute to the metabolic consequences of POC1A deficiency. SOFT syndrome should be included within the group of monogenic ciliopathies with metabolic and adipose tissue involvement, which already encompasses Bardet-Biedl and Alström syndromes.
Transposon Removal Reveals Their Adaptive Fitness Contribution
Authors: Cranz-Mileva Susanne , Reilly Eve , Chalhoub Noor , Patel Rohan , Atanassova Tania , Cao Weihuan , Ellison Christopher , Zaratiegui Mikel 
Published: January 2024

Abstract
Transposable elements are molecular parasites that persist in their host genome by generating new copies to outpace natural selection. Transposable elements exert a large influence on host genome evolution, in some cases providing adaptive changes. Here we measure the fitness effect of the transposable element insertions in the fission yeast Schizosaccharomyces pombe type strain by removing all insertions of its only native transposable element family, the long terminal repeat retrotransposon Tf2. We show that Tf2 elements provide a positive fitness contribution to its host. Tf2 ablation results in changes to the regulation of a mitochondrial gene and, consistently, the fitness effect are sensitive to growth conditions. We propose that Tf2 influences host fitness in a directed manner by dynamically rewiring the transcriptional response to metabolic stress.