bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of ATAD3A as a potential biomarker for bladder cancer
Authors: Liu Zhenghong , Sun Li , Zheng Bin , Wang Heng , Qin Xiaowen , Zhang Pu , Wo Qijun , Li Haichang , Mou Yixuan , Zhang Dahong , Wang Shuai 
Published: November 2023

AbstractBackgroundBladder cancer (BCa) is a highly malignant tumor, and if left untreated, it can develop severe hematuria and tumor metastasis, thereby endangering the patient's life. The purpose of this paper was to detect the expression of ATAD3A in BCa and research the relationship between ATAD3A and pathological features of bladder cancer and the prognosis of patients.MethodsFirst, the expression of ATAD3A in BCa and normal bladder tissues was analyzed based on the UALCAN and Oncomine public databases. Second, 491 cases of surgically resected bladder cancer specimens and 110 cases of normal adjacent tissues were immunohistochemically stained. The expression of ATAD3A was quantified, and the value and prognosis of ATAD3A as a biomarker of BCa were evaluated.ResultsThe expression of ATAD3A in bladder cancer tissues was higher than that in normal bladder mucosa. High expression of ATAD3A was correlated with patient age, tumor size, number of tumors, distant metastasis, lymph node metastasis, lymphovascular invasion, and TNM stage (p < 0.05). Overexpression of ATAD3A is closely related to cancer patient survival. The mean survival time of bladder cancer patients with high ATAD3A expression was shorter than those with low ATAD3A levels. According to the relative comparing result, the high ATAD3A expression herald reduced overall survival in BCa patients.ConclusionsThe abnormal overexpression of ATAD3A may be related to the initiation and progress of bladder cancer. The upregulation of ATAD3A can be used as an effective indicator to diagnose bladder cancer and predict tumor progression. Furthermore, the combination of information from public databases and the results of clinical sample analysis can help us better understand the mechanism of action of molecular oncogenes in bladder cancer.
Identification and Cytotoxic Evaluation of Pregnane Saponins from the Twigs and Leaves of Dregea volubilis
Authors: Diep Vu Thi , Khoa Nguyen Manh , Thu Nguyen Thi , Hien Tran Thi , Tuan Nguyen Hoang , Ha Do Thi 
Published: November 2023

AbstractFour new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside Da1 (1), dregeoside Ka1 (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR‐ESI‐MS analyses) and compared with those in the published literature. Compounds (1–7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN‐7, HT29, A549, MCF‐7, MDA‐MB‐231, and HepG2), revealing varying levels of cytotoxic effects with IC50 values ranging from 4.29 to 21.05 μM. The results indicated that compounds 1–7 may serve as potential lead compounds for the discovery and development of novel anti‐cancer drugs.
Taming the Selective C−H Bond Activation through 1,5‐Palladium Migration
Authors: Fang Yaru , Ding Mingruo , Huang Xueliang 
Published: November 2023

Abstract“Through space” metal/hydrogen shift constitutes one of the efficient elementary step in organometallic chemistry to achieve selective remote C−H bond functionalization. Compared with the relatively extensive exploration on 1,4‐palladium migration, the processes on corresponding 1,5‐palladium translocation are far less explored. Based on our understanding on related research areas, we summarized the advances achieved in remote C−H bond activation through a key step of 1,5‐palladium migration in this minireview. The background, reaction scope, and more importantly, the mechanistic rationale of each transformation was discussed. We hope by reading through this minireview, one could get a general perspective on direct C−H bond activation via 1,5‐palladium/hydrogen shift, and could understand why such a process is less common when compared with the process going through 1,4‐palladium/hydrogen migration, and eventually could be inspired to develop practical ways for the synthesis of valuable molecules, which could not be prepared easily through other traditional approaches.
First‐Row Transition Metal‐Catalyzed Single Hydroelementation of N‐Heteroarenes
Authors: Park Sehoon 
Published: November 2023

AbstractCatalytic partial reduction of N‐heteroarenes with H2 or H[E] (E=Si, B‐based) has been a useful and general method for synthesis of a broad range of dihydropyridines (DHP) and dihydroquinolines (DHQ). In recent seven years, one of the most notable advances in this context is being able to utilize earth‐abundant and inexpensive first‐row transition metal‐based catalytic systems. These catalytic procedures are generally considered more environmentally benign and sustainable when compared to conventional catalytic systems relying on precious metals. This Review describes 20 molecular catalytic systems based on first‐row transition metals for selective single hydroelementation of pyridines and quinolines with H2 surrogate, hydrosilanes, and hydroboranes providing 1,2‐ or 1,4‐dihydropyridines and ‐dihydroquinolines. The observed reaction profiles such as scope and activity are briefly presented, while the proposed working modes over a series of elemental steps – H−[E] bond cleavage, hydride (H−) or hydrogen atom (H⋅) transfer, and product release, are discussed in detail on the basis of experimental and/or computational mechanistic observations and insights.
High‐Performance and Stable Polyaniline@Niobium Sulfide Electrode for an Asymmetric Supercapacitor
Authors: Afzal Amir Muhammad , Iqbal Ahmad , Waqas Iqbal Muhammad , Wabaidur Saikh Mohammad , Al-Ammar Essam A. , Mumtaz Sohail , Ha Choi Eun , Abdul Munnaf Shaik 
Published: November 2023

AbstractConducting polymers have attained a lot of interest due to extraordinary conductivity, large pore size, and surprising stability. In this work, the conducting polymer polyaniline (PANI) and niobium sulfide (NbS) were synthesized by polymerization of aniline and hydrothermal method, respectively. The PANI@NbS nanocomposite electrode material had a specific capacity (Cs) of 1050 C g−1, which is larger than that of the reference sample (NbS = 300 C g−1). Besides, the hybrid device (PANI@NbS//PANI@AC) was designed and the electrochemical characteristics were determined. The hybrid device showed an excellent value of Cs of 1207 C g−1 with higher energy density Ed and power density Pd. The device also exhibited remarkable stability, and 85 % of the initial capacity is retained after 1000 cycles.
Discovery of Unusual Ajmaline‐Macroline Type Bisindole Alkaloids from Alstonia macrophylla by Building Blocks‐Based Molecular Networking
Authors: Li Zi‐Wei , Fan Chun‐Lin , Sun Biao , Huang Lan , Wang Zi‐Qi , Huang Xiao‐Jun , Zhang Shi‐Qing , Ye Wen‐Cai , Wu Zhen‐Long , Zhang Xiao‐Qi 
Published: November 2023

AbstractThree unusual ajmaline‐macroline type bisindole alkaloids, alsmaphylines A–C, together with their postulated biogenetic precursors, were isolated from the stem barks and leaves of Alstonia macrophylla via the building blocks‐based molecular network (BBMN) strategy. Alsmaphyline A represents a rare ajmaline‐macroline type bisindole alkaloid with an S‐shape polycyclic ring system. Alsmaphylines B and C are two novel ajmaline‐macroline type bisindole alkaloids with N‐1−C‐21′ linkages, and the former possesses an unconventional stacked conformation due to the presence of intramolecular noncovalent interactions. The chemical structures including absolute configurations of alsmaphylines A–C were established by comprehensive spectroscopic analyses, electronic circular dichroism (ECD) calculations, and single‐crystal X‐ray crystallography. In addition, a plausible biosynthetic pathway of these bisindole alkaloids as well as their ability to promote the protein synthesis on HT22 cells were discussed.
Hierarchically Porous Covalent Organic Frameworks: Synthesis Methods and Applications
Authors: Wang Xiao , Mu Zhenjie , Shao Pengpeng , Feng Xiao 
Published: November 2023

AbstractCovalent organic frameworks (COFs) with high porosity have garnered considerable interest for various applications owing to their robust and customizable structure. However, conventional COFs are hindered by their narrow pore size, which poses limitations for applications such as heterogeneous catalysis and guest delivery that typically involve large molecules. The development of hierarchically porous COF (HP‐COF), featuring a multi‐scale aperture distribution, offers a promising solution by significantly enhancing the diffusion capacity and mass transfer for larger molecules. This review focuses on the recent advances in the synthesis strategies of HP‐COF materials, including topological structure design, in‐situ templating, monolithic COF synthesis, defect engineering, and crystalline self‐transformation. The specific operational principles and affecting factors in the synthesis process are summarized and discussed, along with the applications of HP‐COFs in heterogeneous catalysis, toxic component treatment, optoelectronics, and the biomedical field. Overall, this review builds a bridge to understand HP‐COFs and provides guidance for further development of them on synthesis strategies and applications.
An Indacenopicene‐based Buckybowl Catcher for Recognition of Fullerenes
Authors: Scholz Barbara , Oshchepkov Alexander S. , Papaianina Olena , Ruppenstein Cordula , Akhmetov Vladimir A. , Sharapa Dmitry I. , Amsharov Konstantin Y. , Pérez‐Ojeda M. Eugenia 
Published: November 2023

AbstractInvited for the cover of this issue are the groups of Alexander S. Oshchepkov, Konstantin Y. Amsharov, and M. Eugenia Pérez‐Ojeda at the Max Planck Institute for the Science of Light, Martin‐Luther‐University Halle‐Wittenberg and Friedrich‐Alexander‐Universität Erlangen‐Nürnberg, respectively. The image depicts a buckybowl catcher carefully framing the C70 fullerene which is associated with miraculous, marvellous Fabergé artworks. Read the full text of the article at 10.1002/chem.202302778.
Optimization of purity and yield of amorphous bio‐silica nanoparticles synthesized from bamboo leaves
Authors: Bindar Yazid , Ramli Yusrin , Steven Soen , Restiawaty Elvi 
Published: November 2023

AbstractThe fallen yellowish bamboo leaves around bamboo crops are always overlooked even though they contain high silica in their ash. Bamboo leaf valorization consequently has the potential to be a green process for synthesizing amorphous silica. Unfortunately, the optimum process parameters have not been widely disclosed. Hence, this study intends to optimize the synthesis of amorphous bio‐silica nanoparticles from bamboo leaves using Box–Behnken design (BBD). Bamboo leaves were initially washed with HCl, followed by combustion at 700°C, and then ash washing, extraction of silica with NaOH (sol–gel method), gelation, and drying. According to the results, optimum conditions occur under no acid washing of leaves, solvent‐to‐feed ratio = 5 mL/g, and extraction duration = 1.5 h. The optimum conditions give the highest purity (94.1 wt.%) and yield (42.33%) as well as the highest surface area (328.61 m2/g), smallest pore diameter (8.69 nm), and largest pore volume (0.71 cc/g) of bio‐silica nanoparticles. Furthermore, bio‐silica nanoparticles are amorphous, spherical‐shaped aggregates, and have a white powdered colour.
Supported Atomically Dispersed Pd Catalyzed Direct Alkoxylation and Allylic Alkylation†
Authors: Qin Ruixuan , Chen Ziwen , Wu Qingyuan , Zheng Nanfeng , Liu Pengxin 
Published: November 2023

Comprehensive SummaryA new approach to allylic alkylation is realized using an atomically dispersed palladium catalyst (Pd1/TiO2‐EG). Unlike conventional methods that require derivation of substrates and utilization of additives, this method allows for direct allylic alkylation from allylic alcohols, producing H2O as the sole by‐product. The catalyst's high efficiency is attributed to the local hydrogen bonding at the organic‐inorganic interface (Pd‐EG interface), facilitating hydroxyl group activation for η3 π‐allyl complex formation. The system demonstrates successful direct C—O and C—C coupling reactions with high selectivity, requiring no additives. This study highlights the potential of supported atomically dispersed catalysts for greener and more efficient catalysis, meanwhile, offers unique insights into the distinct behavior of atomically dispersed catalysts in comparison to homogeneous or nanoparticle‐based catalysts.
Synthesis of Organofluorine Compounds with Acylsilanes†
Authors: Guo Youyuan , Zhou Gang , Shen Xiao 
Published: November 2023

Comprehensive SummaryOrganofluorine compounds are central in synthetic chemistry, medicinal chemistry and material chemistry. In this review, we summarize the investigations on the synthesis of organofluorine compounds with acylsilanes. For the non‐fluorinated acylsilanes, the in situ generation of difluoroenoxysilanes from the reactions of the acylsilanes with trifluoromethylation reagents is the major pathway, leading to the facile preparation of various α,α‐difluoroketones. For the fluoroalkylacylsilanes, apart from the in situ generation of difluoroenoxysilanes through anion Brook rearrangement, radical Brook rearrangement of the photoexcited acylsilanes and the selective control of reactivities of the biradicals pave the way for the synthesis of a variety of organofluorine compounds. In general, most of these reactions gave racemic products, and the asymmetric synthesis of organofluorine compounds with acylsilanes is still rare, which would be a future direction of this field.

Key ScientistsIn 1957, the first acylsilane compound, triphenylsilyl phenyl ketone was reported by Brook group. In 1991, Portella and coworkers reported the reaction of non‐fluorinated acylsilanes and perfluoroorganometallic reagents without Brook rearrangement, resulting in the formation of alcohols as the products. In 1992, Xu and coworkers carried out the first investigation on fluoroalkylacylsilanes for the preparation of difluoroenoxysilanes through anion Brook rearrangement. In 1994, Portella group reported the synthesis of difluoroenoxysilanes with non‐fluorinated acylsilanes and Ruppert‐Prakash reagent. In 2009, Otaka and coworkers reported a NHC‐mediated intramolecular redox reaction to prepare (Z)‐fluoroalkene dipeptide isosteres (FADIs) from γ,γ‐difluoro‐α,β‐ enoylsilane. Until 2022, the application of radical Brook rearrangement of fluoroalkylacylsilanes for the generation of fluoroalkylsiloxycarbenes was achieved by Shen group, enabling the synthesis of fluoroalkylated cyclopropenols. In 2022, Shen and coworkers successfully achieved the trapping of biradical intermediates generated from fluorine‐containing acylsilanes, leading to the facile preparation of fused gem‐difluorooxetanes. In the same year, Shen group reported the first asymetric reactions of fluoroalkylacylsilanes to prepare enantiomerically enriched fluoroalkyl alcohols and difluoroenoxysilanes.
IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children
Authors: Yang Xu , Yang Lihua , Luo Annie , Liu Shanshan , Zhang Xiaohong , Liu Xiaoping , Liu Xiaodan , Luo Ailing , Cai Mansi , Yan Yaping , Wu Xuedong , Huang Ke , Xu Ling , Jiang Hua 
Published: November 2023

AbstractBackgroundAcute lymphoblastic leukemia (ALL) is the most common cancer in children. IKZF3 (IKAROS family zinc finger 3) is a hematopoietic‐specific transcription factor, and it has been validated that it is involved in leukemia. However, the role of IKZF3 single‐nucleotide polymorphisms (SNPs) remains unclear. In this case–control study, the authors investigated the association of IKZF3 SNPs with ALL in children.MethodsSix IKZF3 reference SNPs (rs9635726, rs2060941, rs907092, rs12946510, rs1453559, and rs62066988) were genotyped in 692 patients who had ALL (cases) and in 926 controls. The associations between IKZF3 polymorphisms and ALL risk were determined using odds ratios (ORs) and 95% confidence intervals (CIs). The associations of rs9635726 and rs2060941 with the risk of ALL were further estimated by using false‐positive report probability (FPRP) analysis. Functional analysis in silico was performed to evaluate the probability that rs9635726 and rs2060941 might influence the regulation of IKZF3.ResultsThe authors observed that rs9635726C>T (adjusted OR, 1.49; 95% CI, 1.06–2.11; p = .023) and rs2060941G>T (adjusted OR, 1.51; 95% CI, 1.24–1.84; p = .001) were related to and increased risk of ALL in the recessive and dominant models, respectively. Furthermore, the associations of both rs9635726 (FPRP = .177) and rs2060941 (FPRP < .001) with ALL were noteworthy in the FPRP analysis. Functional analysis indicated that rs9635726 and rs2060941 might repress the transcription of IKZF3 by disrupting its binding to MLLT1, TAF1, POLR2A, and/or RAD21.ConclusionsThis study revealed that IKZF3 polymorphisms were associated with increased ALL susceptibility in children and might influence the expression of IKZF3 by disrupting its binding to MLLT1, TAF1, POLR2A, and/or RAD21. IKZF3 polymorphisms were suggested as a biomarker for childhood ALL.
(B, N)‐Rich B−C−N Nanosheet‐assembled Microwires as Effective Electrocatalysts for Oxygen Reduction Reaction
Authors: Cao Lihua , Yang Tao , Mo Haixin , Zhang Yafang , Gao Yongmin , Xu Zhiyong , Kang Bing , Xia Xuefeng , Zhang Wenhua , Xu Zhihao , Xia Fei , Hou Xue 
Published: November 2023

AbstractDeveloping highly active and stable nanocarbon electrocatalysts for the oxygen reduction reaction (ORR) in alkaline medium has attracted much attention due to their potential as an alternative to traditional metal‐based or noble metal catalysts. Herein, a unique micro‐nano structure of (B, N)‐rich B−C−N nanosheet‐assembled microwires (BCNNAM) were synthesized and driven electrochemical oxide reduction reaction. The diameter of the microwires about 1 μm, while the nanosheets have an average thickness of less than 20 nm. The compact nanosheets are mostly separated with a bending, curling and crumpling morphology. All those constitutes a ternary system with large surface area and abundant activity sites facilitate fast mass/electron transport for ORR catalytic activity. Thus, the B, N‐rich B−C−N nanosheet‐assembled microwires show significantly improved electrocatalytic activity with an onset potential of 0.95 V and half‐wave potential of 0.83 V compared to BNNAM, nitride‐doped carbon, porous carbon and a commercial Pt/C electrocatalyst. Such high catalytic performance of B, N‐rich B−C−N micro‐nano structures is due to the enhanced activity by the coexistence of B, C and N and the mass transfer promoted by the unique hierarchical porous structure.
Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population
Authors: Lavaee Fatemeh , Didar Sahar , Afshari Aylar 
Published: November 2023

AbstractObjectivesThe goal of this study is to measure and compare the hormonal serum levels (estrogen, progesterone, testosterone, prolactin, dihydrotestosterone [DHT]) in trigeminal neuroglia (TN) menopausal women and healthy women.Materials and MethodsThis cross‐sectional and case‐control study was performed in 2018 and 2019. For this study, menopausal women with confirmed TN were enrolled. Twenty‐two healthy women in the control group and 19 in the case group participated. Blood samples were taken from participants for assessment of hormonal serum levels (estrogen, progesterone, testosterone, prolactin, DHT). Data were analyzed by SPSS version 18. Mann−Whitney, T‐test, kormography test, nonmetric, χ2 test, and odds ratios have been used.ResultsIn patients with TN, the serum level of testosterone was significantly higher (p = .036), and the serum level of prolactin (p = .016) was significantly lower. Other evaluated hormones' serum level was identical in the two groups. Patients with abnormal estrogen levels were more in the TN group in comparison with the healthy group. The abnormality of progesterone in TN patients was more in comparison to the healthy control group.ConclusionsEstrogen and progesterone serum levels in TN patients are higher in comparison with the healthy group, while prolactin and testosterone serum levels are lower in the control group. Moreover, the DHE serum level is similar in both groups.
Circulating cytokine and chemokine patterns associated with cytomegalovirus reactivation after stem cell transplantation
Authors: Stern Lauren , McGuire Helen M , Avdic Selmir , Blyth Emily , Gottlieb David , Patrick Ellis , Abendroth Allison , Slobedman Barry 
Published: November 2023

AbstractObjectivesHuman cytomegalovirus (HCMV) reactivation is the leading viral complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT). Understanding of circulating cytokine/chemokine patterns which accompany HCMV reactivation and correlate with HCMV DNAemia magnitude is limited. We aimed to characterise plasma cytokine/chemokine profiles in 36 allo‐HSCT patients (21 with HCMV reactivation and 15 without HCMV reactivation) at four time‐points in the first 100‐day post‐transplant.MethodsThe concentrations of 31 cytokines/chemokines in plasma samples were analysed using a multiplex bead‐based immunoassay. Cytokine/chemokine concentrations were compared in patients with high‐level HCMV DNAemia, low‐level HCMV DNAemia or no HCMV reactivation, and correlated with immune cell frequencies measured using mass cytometry.ResultsIncreased plasma levels of T helper 1‐type cytokines/chemokines (TNF, IL‐18, IP‐10, MIG) were detected in patients with HCMV reactivation at the peak of HCMV DNAemia, relative to non‐reactivators. Stem cell factor (SCF) levels were significantly higher before the detection of HCMV reactivation in patients who went on to develop high‐level HCMV DNAemia (810–52 740 copies/mL) vs. low‐level HCMV DNAemia (< 250 copies/mL). High‐level HCMV reactivators, but not low‐level reactivators, developed an elevated inflammatory cytokine/chemokine profile (MIP‐1α, MIP‐1β, TNF, LT‐α, IL‐13, IL‐9, SCF, HGF) at the peak of reactivation. Plasma cytokine concentrations displayed unique correlations with circulating immune cell frequencies in patients with HCMV reactivation.ConclusionThis study identifies distinct circulating cytokine/chemokine signatures associated with the magnitude of HCMV DNAemia and the progression of HCMV reactivation after allo‐HSCT, providing important insight into immune recovery patterns associated with HCMV reactivation and viral control.
The spectrum of B cells in the pathogenesis, diagnosis and therapeutic applications of immunoglobulin G4‐related disease
Authors: Hao Qiyuan , Sun Meng , Liu Yanying 
Published: November 2023

AbstractImmunoglobulin G4 (IgG4)‐related disease is a chronic fibroinflammatory disease mediated by immune disorders. Given the challenging clinical diagnosis and treatment, knowledge of the pathogenesis of IgG4‐related disease is important. The typical elevation of serum IgG4 concentrations and infiltration of IgG4‐positive plasma cells in the involved tissues indicate the involvement of B lymphocytes in the pathogenesis of IgG4‐related disease. Mass production of autoantibodies reflects abnormal activation of B cells, which causes tissue damage. Circulating plasmablasts are recently discovered markers that correlate with serum IgG4 concentration, the extent of organ involvement and disease activity. B‐cell depletion therapy is an emerging curative strategy that can significantly alleviate clinical manifestations and achieve remission in patients with IgG4‐related disease. These findings highlight the potential role of B cells in IgG4‐related disease. In this review, we discuss the pathogenic impact of B lymphocytes on IgG4‐related disease and describe novel therapies targeting B cells.