bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of acetylcholine immobilization on the electrochemical properties of thiocholine on boron-doped diamond electrode for chlorpyrifos sensor
Authors: Atriardi Shafrizal Rasyid , Hani Adinda Muthia , Putri Gadis 
Published: February 2025

Background: The inhibition reactions of acetylcholinesterase (AChE) have been studied to develop chlorpyrifos biosensors. The performance of AChE, both as a free enzyme and when immobilized on avidin-functionalized magnetic beads (aMB), was evaluated for the hydrolysis of acetylthiocholine. Detection was conducted through the oxidation of thiocholine on a boron-doped diamond (BDD) electrode surface. Methods: The study compared the performance of free and immobilized AChE by analyzing their ability to oxidize thiocholine on the BDD electrode surface. The inhibitory effects of chlorpyrifos were assessed by determining IC10 and IC50 values for both enzyme forms. Additionally, the influence of metal ions (Fe²⁺ and Mn²⁺) on AChE activity was investigated to evaluate interference effects. Findings: Free AChE demonstrated superior performance in thiocholine oxidation compared to the immobilized enzyme. In chlorpyrifos detection, free AChE exhibited a significantly lower IC10 value (3.44 × 10⁻⁶ mM) compared to immobilized AChE (12.9 × 10⁻⁶ mM), and its IC50 value (3.8 × 10⁻⁴ mM) was approximately two orders of magnitude lower than that of the immobilized AChE (5.18 mM). Furthermore, AChE exhibited resistance to metal ion interference, with signal losses of 48.7% and 40.8% in the presence of Fe²⁺ and Mn²⁺ ions, respectively. These findings indicate that the immobilization of AChE must be carefully optimized for effective sensor application. Conclusion: The study highlights the superior performance of free AChE in chlorpyrifos detection compared to its immobilized counterpart. Immobilization significantly affects enzyme sensitivity, resulting in higher inhibitory concentration values. Additionally, AChE demonstrated notable resistance to interference from metal ions. These results emphasize the need for careful consideration when immobilizing AChE for sensor applications. Novelty/Originality or this article: This study provides a detailed comparison between free and immobilized AChE in chlorpyrifos biosensing, highlighting the impact of immobilization on enzyme sensitivity and performance. The findings contribute to the development of more efficient biosensors by emphasizing the importance of optimizing enzyme immobilization strategies.
ANALISIS PENGEMBANGAN KARIR GENERASI Z: TANTAGAN DAN STRATEGI DALAM MEWUJUDKAN SUMBER DAYA MANUSIA BERKUALITAS MELALUI TEKNOLOGI DAN MEDIA
Authors: Syahwatul Khalda Fauziyah  , Damas Elvianto  , Alrida Putri  , Wanda  , Raniasari Bimanti Esthi  
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengembangan karir generasi Z, tantagan dan strategi dalam mewujudkan sumber daya manusia berkualitas melalui teknologi dan media. Metode penelitian yang digunakan metode kualitatif dengan studi lapangan (Field Research) yang dapat diartikan sebagai penelitian kualitatif. Penelitian ini berfokus pada aspek lingkungan dan sosial. Hasil yang diperoleh dalam penelitian ini yaitu Generasi Z memandangnya secara realistis dan realistis secara rasional. Mereka mencari jalur yang jelas untuk pertumbuhan dan kemajuan karir mereka. Mereka menginginkan stabilitas dan kepercayaan diri dalam karir mereka. Generasi Z cenderung mencari peluang yang mendukun pengembangan keterampilan dan karier. Hambatan yang dirasakan oleh Generasi ini dituntut untuk dapat aktif terhadap perubahan global yang cepat dan dinamis, dengan didukung pemilihan jurusan kuliah yang sesuai dengan minat sangatlah penting. Hal ini dikarenakan minat adalah rasa lebih suka dan rasa ketertarikan pada suatu hal atau aktifitas tanpa ada yang menyuruh. Dengan memilih jurusan yang sesuai dengan minat maka mereka akan dapat menjalaninya dengan penuh rasa suka dan antusias. Oleh karena itu, program pengembangan SDM harus mencakup peluang untuk rotasi peran, proyek lintas fungsional, atau pengalaman kerja internasional.
Dinámicas de inversión y empleo en la minería de Cajamarca: Un estudio de fluctuaciones y tendencias, 2009-2023
Authors: Talavera Salas Illich Xavier , Parillo Sosa Enrique Gualberto 
Published: February 2025

El presente artículo tiene como objetivo describir las dinámicas de la inversión y el empleo en el sector minero de Cajamarca entre 2009 y 2023, destacando las fluctuaciones y tendencias clave durante este período. Para ello, se utilizaron datos extraídos del Anuario Minero del Ministerio de Energía y Minas, los cuales fueron analizados para identificar patrones en la inversión minera y las dinámicas del empleo en la región. Los resultados muestran que, a lo largo de este período, la inversión minera experimentó grandes fluctuaciones. En 2011, alcanzó su máximo histórico de 1,437.4 millones de dólares, mientras que, en 2016, debido a la caída de los precios de los metales y los conflictos sociales, se registró una disminución significativa, tocando el mínimo de 208 millones de dólares. A partir de 2017, la inversión comenzó a recuperarse, alcanzando 451.9 millones de dólares en los años siguientes. En relación con el empleo, se observó una creciente externalización de la mano de obra, lo que resultó en un notable aumento de los trabajadores contratistas, quienes superaron al personal directo en las empresas mineras, alcanzando más del 70% del total de trabajadores en 2016. En conclusión, a pesar de la volatilidad del sector, la minería continúa siendo un pilar fundamental para el empleo y el desarrollo económico en Cajamarca. No obstante, las fluctuaciones en la inversión y el empleo siguen representando un desafío importante para la estabilidad y sostenibilidad laboral en la región, especialmente debido a los conflictos sociales y las políticas que afectan tanto a las empresas mineras como a las comunidades locales.
Анализ рынка услуг предприятий малого и среднего бизнеса в сфере нефтегазового проектирования
Authors: ЯНИН А.Н. 
Published: February 2025

Частный малый и средний бизнес в нефтяной промышленности России начал развиваться примерно с начала 1990-х годов. За прошедшие 35 лет роль этих предприятий в отрасли страны значительно возросла. Важное значение деятельность небольших частных предприятий приобретает в сфере нефтегазового проектирования. В статье изложены результаты обработки статистических данных о финансовых показателях деятельности 85 частных проектных компаний РФ. Более половины из них расположены в Тюмени, 22 % – в Москве и 25 % в других городах. Из 85 предприятий к «крупным» отнесено 9, к «средним» – 15, к «малым» – 30, к «микропредприятиям» – 31. Финансовые показатели деятельности указанных предприятий изучены за 2019–2023 гг. Среди них: суммарная выручка (без НДС), прибыль организаций, численность сотрудников, рентабельность бизнеса, стоимость компаний на рынке и др. В целом ситуация на рынке проектных услуг, оказываемых предприятиями малого и среднего бизнеса в нефтяной промышленности России в 2019–2023гг., достаточно сложна. В «реальном выражении», с учетом накопленного индекса инфляции за 2019–2023 гг., ситуация в этих предприятиях проявляет тенденцию к ухудшению.
Private SMEs in the Russian oil industry began to develop around the beginning of the 1990 s. Over the past 35 years the role of these enterprises in the country's industry has increased significantly. The activity of small private enterprises becomes important in the sphere of oil and gas design. The article presents the results of processing statistical data on the financial performance of 85 private design companies in Russia. More than half of them are located in Tyumen, 22 % in Moscow and 25 % in other cities. Out of 85 enterprises 9 are classified as «large», 15 as «medium», 30 as «small» and 31 as «microenterprises». The financial performance of these enterprises has been studied for 2019-2023. Among them: total revenue (excluding VAT), profit of organizations, number of employees, profitability of business, value of companies on the market, etc. In general, the situation in the market of design services provided by small and medium-sized enterprises in the Russian oil industry in 2019–2023 is quite complex. In «real terms», taking into account the accumulated inflation index for 2019–2023, the situation in these enterprises shows a tendency to deteriorate.
Повышение эффективности повторных многостадийных гидравлических разрывов пластов в горизонтальных скважинах
Authors: ДАХНОВСКАЯ Т.В. , КЛИМЕНКО С.А. 
Published: February 2025

Представленный в данной статье комплекс работ по повышению эффективности повторных МС ГРП на месторождениях ПАО «Сургутнефтегаз» позволяет снизить риски и повысить продуктивность скважин после проведенных операций при сохранении либо снижении затрат на проведение работ.
The set of works presented in this article to improve the efficiency of repeated MS hydraulic fracturing operations at the fields of PJSC Surgutneftegas allows to reduce risks and increase well productivity after the operations performed while maintaining or reducing the costs of the work.
Использование современных методов каротажа для оценки состояния ствола скважины с целью минимизации осложнений при спуске хвостовика
Authors: ХАЛИЛОВ А.С. , АРБУЗОВ И.Ю. 
Published: February 2025

В данной статье рассматривается качественное сравнение состояния стволов двух скважин, пробуренных в схожих горно-геологических условиях, на основе современных методов каротажа в процессе бурения LWD (logging while drilling), возможное влияние состояния ствола скважины на спуск хвостовика и методы улучшения состояния ствола скважины путем изменений в дизайне КНБК. Для оценки качества стволов скважин рассматриваются имиджи профилемера на предмет наличия спиралеобразования и уступов, оценки шага и амплитуды спирали и общего и максимального уширения, а также замеры высокой плотности на предмет наличия микроинтенсивностей. Оценка спуска хвостовиков производится по времени спуска в открытом стволе, наличию посадок и значениям коэффициентов трения при спуске.
This article describes qualitative comparison of borehole condition of two wells, which are drilled in similar geological conditions, based on modern LWD tools, possible influence of hole quality on liner run, and methods of hole qualitive improvement by implementation of some changes in BHA design. To access hole quality images of borehole geometry measuring tools (to identify spiraling, ledges, amplitude and pitch of spiral, average and maximum hole OD) and high-frequency surveys (to identify micro DLS) were used. The liners run is assessed based on the trip in time in the open hole, presence of slack-offs during trip in and the values of the friction factors during trip in.
Опыт применения брейкерной системы «БАРКБИТЛ» – «Реагента А» на месторождениях компании ООО «Салым Петролеум Девелопмент»
Authors: ИШБАЕВ Г.Г. , ЛОЖКИН С.С. , СМИРНОВ А.С. 
Published: February 2025

В статье дана краткая информация о технологии химического разрушения фильтрационной корки. Также приведены данные по положительным результатам эксплуатации скважин после обработки «Реагентом А» на месторождениях ООО «Салым Петролеум Девелопмент».
The article provides brief information on the technology of chemical destruction of filter cake. It also provides data on the positive results of well operation after treatment with «Reagent A» at the fields of Salym Petroleum Development LLC.
Решение проблемы определения и оценки достоверной температуры мерзлых пород на месторождениях Крайнего Севера
Authors: КОРОТКОВ С.А. , СПИРИНА О.В. , ГАГАРИНА О.В. 
Published: February 2025

Месторождения Крайнего Севера характеризуются наличием мерзлых пород и связанными с ними осложнениями при строительстве скважин всех назначений. Геокриологические свойства грунтов необходимо знать инженерам проектных организаций еще на стадии проектирования разработки месторождений и строительства скважин. Достоверная информация об основных параметрах мерзлоты нужна для теплотехнических и прочностных расчетов, для правильного выбора оптимальных реологических характеристик бурового, тампонажного растворов и технологических жидкостей. Но в настоящее время вопрос определения и оценки реальных термобарических значений мерзлых пород до начала строительства эксплуатационных скважин стоит остро. Авторами статьи проведен анализ существующих способов определения термобарических параметров мерзлоты (на примере температуры грунтов) и даны рекомендации по выбору рационального метода.
The deposits of the Far North are characterized by the presence of frozen rocks and the complications associated with them during the construction of wells of all purposes. Geocryological properties of soils must be known to engineers of design organizations already at the stage of designing the development of deposits and construction of wells. Reliable information on the main parameters of permafrost is needed for heat engineering and strength calculations, for the correct selection of optimal rheological characteristics of drilling, cement solutions and process fluids. But at present, the issue of determining and assessing the actual thermobaric values of frozen rocks before the construction of production wells is acute. The authors of the article analyzed the existing methods for determining the thermobaric parameters of permafrost (using the soil temperature as an example) and gave recommendations on choosing a rational method.
Винтовой забойный двигатель с профилированной двигательной секцией: повышение эффективности бурения при ограниченном расходе промывочной жидкости
Authors: ШУТЕНКОВ А.А. , КРИВОШЕЕВ А.В. , ПЕТУХОВ А.В. , КУЗНЕЦОВ А.В. 
Published: February 2025

Основным видом деятельности ООО «Фирма «Радиус-Сервис» является производство нефтепромыслового оборудования. Компания осуществляет полный производственный цикл от разработки, изготовления до поставки оборудования. Основная продукция – винтовые забойные двигатели. «Радиус-Сервис» обладает широким рядом типоразмеров ВЗД, что позволяет использовать оборудование в различных эксплуатационных условиях и быть эффективным при выполнении сложных технологических операций.
The key business activity of LLC Firma Radius-Servis is the production of oilfield equipment. The company covers the complete product cycle from development and manufacturing to delivery to the customer. Its staple product is the downhole motor. Radius-Servis offers a vast selection of motor sizes, which are suited to diverse operating conditions and effectively address complex technological operations.
Безопасный и эффективный метод бурения скважин в Республике Беларусь с использованием технологии бурения с регулируемым давлением
Authors: ПАВЛОВ В.С. 
Published: February 2025

В данной работе приводится описание результатов первого успешного строительства скважины в Республике Беларусь с целевым коллектором туровских слоев елецкого горизонта с применением технологии по бурению с регулируемым давлением компанией ООО «БурСервис». Подготовка к оказанию услуг в Республике Беларусь производилась в кратчайшие сроки, в ходе которой был разработан и применен новый дизайн оборудования, а также созданы нестандартные практики по ведению работ.
This paper describes the results of the first successful construction of a well in the Republic of Belarus with a target reservoir of the Turov layers of the Yelets horizon using MPD technology by Burservise. Preparation for the provision of services in the Republic of Belarus was carried out as soon as possible, during which a new design of equipment was developed and applied, as well as non-standard work practices were created.
FAKTOR-FAKTOR YANG MEMPENGARUHI PERILAKU KONSUMEN WARUNG PECEL LELE DI JALAN KI MAJA BANDAR LAMPUNG (Studi Kasus Pada Warung Pece lele Di Jalan Kimaja Bandar Lampung)
Authors: Kurniawan Rudi , Prikurnia Anas Khair , Nurbaiti Seni 
Published: February 2025

ABSTRAKDengan melihat peluang yang ada langkah awal yang ditempuh oleh pengusaha menentukan lokasi tempat usahanya. Faktor lokasi merupakan hal penting bagi usahanya. bahwa ciri umum lokasi yang baik untuk usaha jasa makanan misalnya bertempat dekat lokasi penduduk, dekat kompleks perkantoran, dekat suatu tempat hiburan atau tempat lain yang harus diperhatikan dalam memilih lokasi yang tepat bagi suatu usaha jasa makanan Penelitian termasuk jenis penelitian survey dilakukan pada populasi besar maupun kecil, data yang diperlukan adalah dari sampel yang diambil dari populasi t, sehingga kejadian-kejadian relatif, distribusi, hubungan- hubungan antar variabel sosiologis maupun psikologis.Metode data diperoleh melalui kuesioner, cara pengumpulan data dengan memberikan daftar pertanyaan kepada responden untuk diisi, dan wawancara, yaitu metode pengumpulan data dengan cara bertanya langsung dengan respondenHipotesis pertama yang menyatakan bahwa faktor pendapatan (X1), lokasi (X2), pelayanan (X3), selera (X4), kebersihan (X5), rekreasi (X6) dan harga (X7), berpengaruh secara signifikan terhadap perilaku konsumen pada warung pecel lele di jalan Kimaja Bandar Lampung diterima. Artinya bila faktor pendapatan (X1), lokasi (X2), pelayanan (X3), selera (X4), kebersihan (X5), rekreasi (X6) dan harga (X7) semakin meningkat maka perilaku konsumenBerdasar kesimpulan diatas, selanjutnya dapat diusulkan saran yang diharapkan akan bermanfaat bagi warung pecel lele di sepanjang jalan Kimaja yang berkaitan dengan peningkatan faktor – faktor pendapatan (X1), lokasi (X2), pelayanan (X3), selera (X4), kebersihan (X5), rekreasi (X6) dan harga (X7) untuk menumbuhkan Perilaku konsumen Langkah yang dilakukan selalu meningkatkan kualitas produk dengan menggunakan bahan-bahan yang halal dan menambah variasi Kata Kunci: Perilaku konsumen, Lokasi, dan Penjualan
PERFIL EPIDEMIOLÓGICO DE NASCIDOS VIVOS COM BAIXO PESO NO ESTADO DO PARÁ NO PERÍODO DE 2018 A 2020
Authors: Oliveira Janaina Maria Medeiros Teotonio , Souza Vilma Francisca Hutim Gondim de 
Published: February 2025

O objetivo do trabalho apresentado abaixo é descrever o perfil epidemiológico dos nascidos vivos com baixo peso no Pará no período de 2018 a 2020. Para esse fim, foi realizado estudo descritivo com dados do departamento de Informática do Sistema Único de Saúde (DATASUS) referentes aos de 2018 a 2020; a busca inicial foi realizada sob o tópico “Estatísticas Vitais”, em seguida “Nascidos vivos - desde 1994", “Nascidos vivos”, com delimitação das notificações referentes aos casos no Estado do Pará. A coleta de dados foi, em seguida, realizada por meio de cruzamentos "linha/coluna", utilizando-se “ Peso ao nascer” e relacionando com os campos para se fazer verificação dos dados "Idade da mãe", “Instrução da mãe”, “Duração gestação”, “Tipo de gravidez”, “Tipo de parto”, “Consultas pré natal”, “Sexo”, “Cor/raça”, “Apgar 1º minuto”, “Apgar 5º minuto” e “Anomalia congênita” , selecionando para todos o período de 2018 a 2020. Foi verificado um total de 31.653 casos de nascidos vivos com peso inferior a 2.500 gramas, resultando em uma taxa de 7,66%. Assim, observou-se que a taxa de baixo peso está menor que a nacional (8,59%) e próxima a da Região Norte (7,69%). No entanto, mais de 50% dos óbitos infantis no mesmo período ocorreu a em crianças que nasceram com baixo peso. Além disso, os dados encontrados no DATASUS apontam como fator de risco para baixo peso ao nascer: sexo feminino, raça/cor preta, mães com idade inferior a 20 anos ou superior a 35 anos, baixo nível de escolaridade materna, prematuridade, gemelaridade e via de parto vaginal, essa última podendo estar ligada às condições socioeconômicas maternas. Como desfecho, verificou-se que o estado do Pará apresenta índices inferiores aos índices brasileiros, o que pode estar relacionado à subestimação de dados e reafirma a necessidade de políticas públicas direcionadas à população materno-infantil.
From Preference to Priority: The Surge in Demand for Organic Foods
Authors: Jolly Masih, Suresh Chandra Sharma  , Neha Saini, Dinesh Kumar Yadav  
Published: February 2025

This study examines the evolving perceptions of organic food consumption across three phases: Pre-COVID, during COVID, and Post-COVID. It explores the impact of the pandemic on consumer behavior and preferences by leveraging data from over 600,000 interactions on platforms such as Twitter, Facebook, YouTube, and online forums. Using Latent Dirichlet Allocation (LDA) and perceptual map scoring, this study identifies key trends and drivers shaping consumer choices, and provides a detailed comparison of attitudes during these critical periods. Key theoretical frameworks underpin this analysis. The Health Belief Model (HBM) explains how perceptions of health benefits and risks influenced the shift toward organic foods, particularly during the pandemic when health consciousness peaked. Similarly, the Protection Motivation Theory (PMT) highlights the role of perceived threats, such as chemical exposure in conventional foods, in driving consumers to prioritize organic options for their safety and health benefits. Furthermore, the Diffusion of Innovations Theory (DOI) underscores the role of social media in spreading awareness and encouraging adoption of organic food trends, amplifying consumer engagement during and after the pandemic. The findings reveal a significant surge in the demand for organic foods during the pandemic, driven by heightened health concerns and a desire to support local agriculture and sustainable practices. In the Post-COVID era, these changes reflect a lasting consumer commitment to health and environmental responsibility. This study offers valuable insights for policymakers, marketers, and producers, emphasizing the importance of adapting strategies to meet evolving consumer expectations in a more health-conscious and sustainability-focused market.
Revisão integrativa da infecção pelo Zika vírus durante a gravidez: Implicações para o feto e para gestante
Authors: Linhares Marcelly Maria Oliveira , Neto Francisco Jazon de Araújo , Sales Ana Beatriz Coelho , Oliveira Ramiro Gonçalves , Moura Victor José Carneiro de , Alencar Francisco Andérek Bezerra , Vital Pedro Italo Ferreira , Bortoletti Everton Gabriel , Colares Fernanda Cafezakis Coelho Amoedo , Nogueira Leonardo Bico , Pinto Ícaro Rodrigues Mendes Pedrosa , Araújo Lia Cavalcante de 
Published: February 2025

Objetivo: Analisar e descrever o impacto do Zika vírus (ZIKV) na gravidez e suas principais consequências para a mãe e o bebê. Método: O presente estudo é uma revisão de literatura de abordagem qualitativa e exploratória, que buscou artigos na base de dados do PubMed, por meio da ferramenta de busca: "Zika" AND "Pregnancy", sendo encontrados 2.430 artigos. Resultados e Discussões: O ZIKV é um flavivírus transmitido para os seres humanos pelo mosquito do gênero Aedes, sendo transmitido também por meio sexual ou vertical. Desse modo, tal doença pode apresentar um risco maior a depender do trimestre de exposição da gestante, isso se deve ao fato de que a placenta pode atuar como barreira de proteção após a décima semana gestacional, antes disso o bebê exposto está mais vulnerável aos agentes teratogênicos. Nesse contexto, observa-se que a ZIKV é um grande fator de risco gestacional, que tem como sítio de infecção o cérebro fetal, placenta e cordão umbilical, e induz respostas inflamatórias no feto. Conclusão: Dessa forma, busca-se prevenir essa infecção, por meio do uso de repelentes, roupas que minimizem a exposição da pele e impedir o acesso do mosquito a locais com acúmulo de água.
Upholding Research Integrity in Nursing Research
Authors: Paudel Kalpana 
Published: February 2025

Research integrity is paramount in the field of nursing research. It serves as the foundation for ethical practice, the advancement of nursing knowledge, and evidence-based care. However, unethical research practices can significantly undermine this foundation, leading to misguided clinical practices and potential harm to patients. Understanding the implications of unethical research and emphasizing the importance of integrity are crucial for nursing professionals.