bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing a new exchange functional by altering the electron density’s ionization dependency in density functional theory
Authors: Rahmatpour E. , Esmaeili A. 
Published: February 2024

AbstractEach of the exchange–correlation functionals in the density functional theory has been customized to particular systems or elements and has unique advantages and disadvantages. In one of the most recent research on exchange–correlation functionals, Chachiyo et al. present a relationship for exchange–correlation functional by assuming the simplest form of electron density. Their utilized electron density causes a systematic inaccuracy in the energy of the molecules since it does not fully account for the variation of the ionization energy for different atoms. We offer a novel relationship for exchange functional that improves the precision of the energy calculations for molecules by using the basic assumptions of the Chachiyo approach and correcting the electron density. Our density is directly related to the atom’s ionization energy. Our suggested functional was implemented for 56 molecules composed of atoms from the first, second, and third rows of the periodic table using Siam Quantum package. We discussed about the role of our functional on the reducing the computation error of dipole moment along with total, bonding and zero point energies. We also increased the portion of core electrons to improve the accuracy of the results.
High FSH levels impair VEGF secretion of human, frozen-thawed ovarian cortical tissue in vitro
Authors: Einenkel Rebekka , Schallmoser Andreas , Sänger Nicole 
Published: February 2024

AbstractCryopreservation and reimplantation of human ovarian tissue restore the ovarian hormonal function and fertility due to the preservation of follicles. As the success depends on proper angiogenesis, different approaches aim to support this process. In mice, pretreatment of ovarian tissue with FSH shows increased follicular numbers probably due to the supported angiogenesis by an increased vascular endothelial factor (VEGF) expression. However, in human tissue it remains completely unclear, which effect the hormonal status of the patient has at the time point of reimplantation. Frozen-thawed human ovarian cortical tissue was cultured for 48 h with 0, 1 or 10 ng/mL recombinant human FSH. VEGF-A expression was assessed by ELISA and immunohistofluorescence (IHF) analysis. By IHF, HIF-1α and FSHR expression dependency on culture and FSH concentration was analyzed. Follicles at all stages expressed VEGF-A, which increases during folliculogenesis. Frozen-thawed human ovarian cortical tissue secreted a not statistically different amount of VEGF-A, when cultured in presence of 1 ng/mL FSH (17.5 mIU/mL). However, the presence of 10 ng/mL FSH (175 mIU/mL) significantly decreased VEGF-A expression and secretion. The high FSH concentration increased especially the VEGF-A expression of already growing follicles. The presence of pre-menopausal concentrations of FSH had no significant effect on VEGF-A expression, whereas the presence of elevated FSH levels decreased cortical VEGF-A expression. A hormonal pre-treatment of women with elevated FSH concentrations prior to reimplantation might be considered to support angiogenesis. Here, we show that VEGF-A expression by follicles is affected by FSH dependent on the concentration.
Multi-objective hybrid split-ring resonator and electromagnetic bandgap structure-based fractal antennas using hybrid metaheuristic framework for wireless applications
Authors: Palanisamy SatheeshKumar , Rubini S Saranya , Khalaf Osamah Ibrahim , Hamam Habib 
Published: February 2024

AbstractDesign closure and parameter optimisation are crucial in creating cutting-edge antennas. Antenna performance can be improved by fine-tuning preliminary designs created using theoretical considerations and rough dimension adjustment via supervised parameter sweeps. This paper introduces a frequency reconfigurable antenna design that can operate at 28/38 GHz frequencies to meet FCC and Ofcom standards for 5G applications and in the 18 GHz frequency band for K-band radar applications. A PIN diode is used in this design to configure multiple frequency bands. The antenna has a modified rectangular patch-like structure and two optimised plugins on either side. The study that is being presented focuses on maximising the parameters that are subject to optimisation, including length (Ls), width (Ws), strip line width (W1), and height (ht), where the antenna characteristic parameters such as directivity is tuned by a hybrid optimisation scheme called Elephant Clan Updated Grey Wolf Algorithm (ECU-GWA). Here, the performance of gain and directivity are optimally attained by considering parameters such as length, width, ground plane length, width, height, and feed offsets X and Y. The bandwidth of the proposed antenna at − 10 dB is 0.8 GHz, 1.94 GHz, and 7.92 GHz, respectively, at frequencies 18.5 GHz, 28.1 GHz, and 38.1 GHz. Also, according to the simulation results, in the 18 GHz, 28 GHz, and 38 GHz frequencies S11, the return loss is − 60.81 dB, − 56.31 dB, and − 14.19 dB, respectively. The proposed frequency reconfigurable antenna simulation results achieve gains of 4.41 dBi, 6.33 dBi, and 7.70 dBi at 18.5 GHz, 28.1 GHz, and 38.1 GHz, respectively. Also, a microstrip quarter-wave monopole antenna with an ellipsoidal-shaped complementary split-ring resonator-electromagnetic bandgap structure (ECSRR-EBG) structure has been designed based on a genetic algorithm having resonating at 2.9 GHz, 4.7 GHz, 6 GHz for WLAN applications. The gain of the suggested ECSRR metamaterial and EBG periodic structure, with and without the ECCSRR bow-tie antenna. This is done both in the lab and with numbers. The measured result shows that the ECSRR metamaterial boosts gain by 5.2 dBi at 5.9 GHz. At 5.57 GHz, the two-element MIMO antenna achieves its lowest ECC of 0.00081.
Evaluation and deployment of a unified MPPT controller for hybrid Luo converter in combined PV and wind energy systems
Authors: Kumar K. , Lakshmi Devi V. , Dhanamjayulu C. , Kotb Hossam , ELrashidi Ali 
Published: February 2024

AbstractThis work emphasizes the development and examination of a Hybrid Luo Converter integrated with a unified Maximum Power Point Tracking (MPPT) for both grid and independent hybrid systems. The primary objectives of this hybrid system are to efficiently harness power from intermittent and variable renewable sources while elevating low-voltage energy inputs to utility-grade levels. Unlike previous studies employing specific MPPT algorithms for solar and wind sources, this work aims to simplify the control system by utilizing a unified MPPT controller. This research also introduces a novel approach involving dual-lift hybrid Luo converters to create hybrid systems, operating exclusively or concurrently based on the availability of renewable resources. To maximize power generation from all renewable sources, a unified MPPT algorithm is developed. The hybrid system, incorporates 500 W wind and 560 W PV systems, the innovative Luo converter, and the unified MPPT controller. A comprehensive comparative analysis is presented, comparing the hybrid system's performance with that of traditional control algorithms, such as the Perturb & Observe, and Radial Basis Function Network controllers. The successful prototype of the converter validates the practicality of the proposed approach.
Application of PET imaging delta radiomics for predicting progression-free survival in rare high-grade glioma
Authors: Ahrari Shamimeh , Zaragori Timothée , Zinsz Adeline , Oster Julien , Imbert Laetitia , Verger Antoine 
Published: February 2024

AbstractThis study assesses the feasibility of using a sample-efficient model to investigate radiomics changes over time for predicting progression-free survival in rare diseases. Eighteen high-grade glioma patients underwent two L-3,4-dihydroxy-6-[18F]-fluoro-phenylalanine positron emission tomography (PET) dynamic scans: the first during treatment and the second at temozolomide chemotherapy discontinuation. Radiomics features from static/dynamic parametric images, alongside conventional features, were extracted. After excluding highly correlated features, 16 different models were trained by combining various feature selection methods and time-to-event survival algorithms. Performance was assessed using cross-validation. To evaluate model robustness, an additional dataset including 35 patients with a single PET scan at therapy discontinuation was used. Model performance was compared with a strategy extracting informative features from the set of 35 patients and applying them to the 18 patients with 2 PET scans. Delta-absolute radiomics achieved the highest performance when the pipeline was directly applied to the 18-patient subset (support vector machine (SVM) and recursive feature elimination (RFE): C-index = 0.783 [0.744–0.818]). This result remained consistent when transferring informative features from 35 patients (SVM + RFE: C-index = 0.751 [0.716–0.784], p = 0.06). In addition, it significantly outperformed delta-absolute conventional (C-index = 0.584 [0.548–0.620], p < 0.001) and single-time-point radiomics features (C-index = 0.546 [0.512–0.580], p < 0.001), highlighting the considerable potential of delta radiomics in rare cancer cohorts.
Methemoglobin levels in malaria: a systematic review and meta-analysis of its association with Plasmodium falciparum and Plasmodium vivax infections and disease severity
Authors: Kotepui Manas , Mahittikorn Aongart , Wilairatana Polrat , Masangkay Frederick Ramirez , Wangdi Kinley , Kotepui Kwuntida Uthaisar 
Published: February 2024

AbstractReports indicate that Plasmodium infections influence methemoglobin levels. However, findings have been inconclusive or have varied across different geographic and demographic contexts. This systematic review and meta-analysis aimed to consolidate existing data regarding the association between Plasmodium infections and alterations in methemoglobin levels related to the severity of the infection. A comprehensive literature search of several databases, including Ovid, ProQuest, Embase, Scopus, MEDLINE, and PubMed, was conducted to identify relevant studies that examined methemoglobin levels in patients with malaria. Qualitative synthesis and meta-analysis of the pooled standardized mean difference were conducted to synthesize the differences in methemoglobin levels between: (1) patients with malaria and those without malaria and (2) patients with severe malaria and those with uncomplicated malaria based on various themes including publication year, study design, study area, Plasmodium species, age group, symptomatic status, severity status, and method of malaria detection. Of the 1846 studies that were initially identified from the main databases and additional searches on Google Scholar, 10 studies met the eligibility criteria and were selected for this review. The systematic review distinctly highlighted an association between malaria and elevated methemoglobin levels, an observation consistent across diverse geographical regions and various Plasmodium species. Furthermore, the meta-analysis confirmed this by demonstrating increased methemoglobin levels in patients with malaria compared to those without malaria (P < 0.001, Hedges’ g 2.32, 95% CI 1.36–3.29, I2 97.27, 8 studies). Moreover, the meta-analysis found elevated methemoglobin levels in patients with severe malaria compared to those with uncomplicated malaria (P < 0.001, Hedges’ g 2.20, 95% CI 0.82–3.58, I2 96.20, 5 studies). This systematic review and meta-analysis revealed increased methemoglobin levels in patients with P. falciparum and P. vivax infections, with a notable association between elevated methemoglobin levels and severe malaria. Future research should focus on elucidating the specific mechanisms by which changes in methemoglobin levels are related to infections by P. falciparum and P. vivax, particularly in terms of severity, and how these alterations could potentially impact patient management and treatment outcomes.
The effect of perceived social support and health literacy on parental COVID-19 vaccine hesitation in preschool children: a cross-sectional study
Authors: Chen Jiayue , Wang Quqing , Jiang Nan , Zhang Yuxin , Wang Ting , Cao He , Liu Yongyi , Yang Yonghui , Wang Jiwei 
Published: February 2024

AbstractChildren are generally susceptible to COVID-19, and infection with COVID-19 may cause serious harm to children. COVID-19 vaccination is an effective way to prevent infection at present, and many factors affect children's COVID-19 vaccination. This study aimed to explore the effects of perceived social support and health literacy on hesitancy towards first and second vaccine dose. This cross-sectional study was conducted in the Minhang District of Shanghai, China, in October 2022. A total of 1150 parents of preschool children from 10 kindergartens participated. The survey encompassed four sections, capturing data on sociodemographic attributes, health literacy, perceived social support, and parental COVID-19 vaccine hesitancy. Health literacy was measured using a self-designed questionnaire consisting of four dimensions. Perceived social support was assessed using the MSPSS questionnaire. Hierarchical multiple logistic regression was used to examine the relationship between the independent variables and parental hesitancy towards the first and second doses of COVID-19 vaccine. Parental hesitancy rate for the first dose of the COVID-19 vaccine was 69.6%, and for the second dose, it was 33.1%. The final integrated model showed that parental hesitancy towards the first and the second dose of COVID-19 vaccine was associated with parental educational level, allergy in children, information decision-making and information comprehension ability, perceived social support from family and friends. Health literacy and perceived social support are influence factors for parental hesitancy towards COVID-19 vaccine for preschool children. The findings will provide insights for future intervention studies on COVID-19 vaccine hesitancy and inform the development of vaccination policies.
The impact of digital healthcare systems on pain and body function in patients with knee joint pain: a systematic review and meta-analysis
Authors: Guo Longfei , Li Shuoqi , Xie Shihao , Bian Lin , Shaharudin Shazlin 
Published: February 2024

AbstractThe digital healthcare (DH) system has recently emerged as an advanced rehabilitation approach that promotes rehabilitation training based on virtual reality (VR) and augmented reality (AR). The purpose of this meta-analysis study is to review and assess the impact of DH systems on pain and physical function among patients diagnosed with knee joint pain. Between January 2003 and September 2023, studies that met the listed inclusion criteria were gathered from Scopus, PubMed, Web of Science, and EBSCO databases. The analysis of standardized mean difference (SMD) was carried out with 95% confidence interval (95% CI) (PROSPERO registration number: CRD42023462538). Nine research papers were selected, which collectively involved 194 males and 279 females. The meta-analysis outcomes revealed that DH intervention significantly improved balance (SMD, 0.41 [0.12, 0.69], p < 0.05) and pain level (SMD, − 1.10 [− 2.02, − 0.18], p < 0.05). The subgroup analysis of the pain level showed varied outcomes for the TKA (SMD, − 0.22 [− 0.49, 0.04], p = 0.10) or OA patients (SMD, − 2.80 [− 3.83, − 1.78], p < 0.05) Next, this study found no significant effect of DH intervention on knee joint range of motion (ROM) (SMD, 0.00 [− 0.76, 0.76], p = 1.00) and walking velocity (SMD, 0.04 [− 0.22, 0.29], p = 0.77) in patients with knee joint pain. The meta-analysis review conducted in this study revealed that DH intervention may potentially improve balance among the patients with knee joint pain. It may also alleviate the pain level particularly among OA patients.
Research and development of fully enclosed wire-shell support structure technology for deep soft rock roadway based on TRIZ theory
Authors: Yao Weijing , Wang Chengjun , Pang Jianyong , Liu Yushan , Zhang Jinsong 
Published: February 2024

AbstractThe TRIZ theory was used to accurately discover the problems to be solved in the design of roadway surrounding rock control technology. This paper tried to solve the complex issue of surrounding rock control in deep roadways from a new perspective. Based on the functional component analysis and causal axis analysis of the problem’s primary reason, simultaneously, the surrounding rock control technology was optimized through technical contradiction analysis, physical contradiction analysis, and substance and field model analysis. As a result, a fully enclosed wire-shell support technology was proposed. Finally, taking the typical soft rock roadway engineering of Pansan Coal Mine in Huainan Mining Area, Anhui Province, China, as the engineering background, the engineering application and effect evaluation were completed. This paper provides a reference for controlling the instability of deep soft rock roadways in coal mines. A new idea of optimizing roadway support engineering based on TRIZ theory was proposed.
Van der Waals enabled formation and integration of ultrathin high-κ dielectrics on 2D semiconductors
Authors: Sebek Matej , Wang Zeng , West Norton Glen , Yang Ming , Neo Darren Chi Jin , Su Xiaodi , Wang Shijie , Pan Jisheng , Thanh Nguyen Thi Kim , Teng Jinghua 
Published: February 2024

AbstractA thin dielectric layer is an important constituent element in 2D materials-based electronics and photonics. Current methods of using hexagonal boron nitride (hBN) and direct deposition of dielectric layer induce either high leakage current or unintentional doping and defect. Here we report a technique for damaging free integration of dielectric layer to form high-quality van der Waals (vdW) heterostructure. The dielectric layer is grown by atomic layer deposition (ALD) on 2D materials and then deterministically transferred on the target 2D material. The much weaker binding energy between the ALD dielectric and the 2D materials enables the growth and exfoliation of the atomically thin dielectrics, which is confirmed by the X-ray photoelectron spectroscopy analyses and the density function theory calculations. The effectiveness of the technology is proven by the Raman and photoluminescence measurement on WS2 monolayer protected by the dielectric film through harsh plasma treatment. Furthermore, a 2D materials-based MOSFET is constructed as a demonstration of the viability of the technology for electronic device applications. The method produces flat surfaces and clean interfaces and would greatly benefit electronic and photonic applications as encapsulation or high-κ gate dielectric.
Fast-reconfigurable frequency comb generation based on AlGaAsOI waveguide with electro-optic time lens
Authors: Ma Chunyang , Wang Chaopeng , Pi Yazhi , Wang Lei , He Zhixue , Huang Jiahui , Xie Weiqiang , Bowers John E. , Chang Lin , Cao Zizheng , Yu Shaohua 
Published: February 2024

AbstractTunable optical frequency combs offer a flexible solution for specific applications such as dual-comb spectroscopy, optical communications and microwave photonics, delivering improved precision, compatibility, and performance. However, previously, there has been a trade-off between reconfigurability and system simplicity in comb generation. Here, we present a fast-switched repetition rate frequency comb system that utilizes an electro-optic modulation time-lens technique with a high third-order nonlinear AlGaAsOI waveguide. Only one stage of modulator is used in the time-lens system which significantly reduces the complexity of the overall system. Our system allows for tuning of the center wavelength from 1542 nm to 1556 nm, as well as independent adjustment of the repetition rates from 18 GHz to 26.5 GHz, enabling fast-switching capabilities. Additionally, our system exhibits a high pump-to-comb conversion efficiency of up to 67.9%. It also demonstrates robustness to temperature changes and environmental instability. All the involved devices can be integrated onto a single chip, making this comb suitable for various applications.
Detection of thin film phase transformations at high-pressure and high-temperature in a diamond anvil cell
Authors: Berrada Meryem , Hu Genzhi , Zhou Dongyuan , Wang Siheng , Nguyen Phuong Q. H. , Zhang Dongzhou , Prakapenka Vitali , Chariton Stella , Chen Bin , Li Jie , Nicholas Jason D. 
Published: February 2024

AbstractQuantifying how grain size and/or deviatoric stress impact (Mg,Fe)2SiO4 phase stability is critical for advancing our understanding of subduction processes and deep-focus earthquakes. Here, we demonstrate that well-resolved X-ray diffraction patterns can be obtained on nano-grained thin films within laser-heated diamond anvil cells (DACs) at hydrostatic pressures up to 24 GPa and temperatures up to 2300 K. Combined with well-established literature processes for tuning thin film grain size, biaxial stress, and substrate identity, these results suggest that DAC-loaded thin films can be useful for determining how grain size, deviatoric stress, and/or the coexistence of other phases influence high-pressure phase stability. As such, this novel DAC-loaded thin film approach may find use in a variety of earth science, planetary science, solid-state physics, and materials science applications.
Chromatin binding by HORMAD proteins regulates meiotic recombination initiation
Authors: Milano Carolyn R , Ur Sarah N , Gu Yajie , Zhang Jessie , Allison Rachal , Brown George , Neale Matthew J , Tromer Eelco C , Corbett Kevin D , Hochwagen Andreas 
Published: February 2024

AbstractThe meiotic chromosome axis coordinates chromosome organization and interhomolog recombination in meiotic prophase and is essential for fertility. In S. cerevisiae, the HORMAD protein Hop1 mediates the enrichment of axis proteins at nucleosome-rich islands through a central chromatin-binding region (CBR). Here, we use cryoelectron microscopy to show that the Hop1 CBR directly recognizes bent nucleosomal DNA through a composite interface in its PHD and winged helix–turn–helix domains. Targeted disruption of the Hop1 CBR-nucleosome interface causes a localized reduction of axis protein binding and meiotic DNA double-strand breaks (DSBs) in axis islands and leads to defects in chromosome synapsis. Synthetic effects with mutants of the Hop1 regulator Pch2 suggest that nucleosome binding delays a conformational switch in Hop1 from a DSB-promoting, Pch2-inaccessible state to a DSB-inactive, Pch2-accessible state to regulate the extent of meiotic DSB formation. Phylogenetic analyses of meiotic HORMADs reveal an ancient origin of the CBR, suggesting that the mechanisms we uncover are broadly conserved.