bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Cardiac Effects of Modern Treatment for Hodgkin’s Lymphoma
Authors: Bjerring Anders W , Smeland Knut HB , Stokke Thomas , Haugaa Kristina H , Holte Espen , Rösner Assami , Kiserud Cecilie E , Edvardsen Thor , Sarvari Sebastian Imre 
Published: January 2024

Abstract
Background: Hodgkin’s lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the cardiac health of HL survivors (HLS).
Methods: HLS (n=246) treated between 1997 and 2007 with anthracycline-based chemotherapy in three centers in Norway were included. Of these, 132 (53%) had also received mediastinal radiotherapy. HLS were compared to controls (n=58) recruited from the general population and matched for sex, age, smoking status, and heredity for coronary artery disease. All subjects underwent echocardiography, clinical assessment, and blood sampling.
Results: The HLS were 46±9 years old and had been treated 17±3 years before inclusion in the study. There was no significant difference between HLS and controls in ejection fraction (EF) (58%±5 vs. 59%±4, p=0.08) or prevalence of heart failure. HLS treated with both anthracyclines and mediastinal radiotherapy (AC+MRT) had slightly worse left ventricular global longitudinal strain than controls (‑19.3±2.5% vs. -20.8±2.0%, p<0.001), but those treated with only anthracyclines did not. HLS treated with AC+MRT had a higher prevalence of valve disease than those treated only with anthracyclines (12% vs. 4%, p<0.05).
Conclusions: HLS treated with anthracyclines after the late 1990s have similar cardiac outcomes as age-matched controls, apart from higher rates of valvular disease in those who also underwent mediastinal radiotherapy.
What Do We Know About Abnormal Uterine Bleeding Following Vaccination Against Covid-19 After Two and A Half Years Of Experience? A Systematic Review and Meta- Analysis
Authors: Sharon Nataly Zilberman , Maymon Ron , Svirsky Ran , Novikov Ilya , Cuckle Howard , Levtzion-Korach Osnat 
Published: January 2024

Abstract

Vaccination against COVID-19 is regarded to be most effective in preventing morbidity and mortality and limiting the spread of the virus. Publications in the media and scientific journals have raised a concern regarding abnormal uterine bleeding as a COVID-19 vaccine side effect. We aimed to estimate the prevalence of abnormal uterine bleeding after vaccination against COVID-19. Medline, PubMed, Embase and Google Scholar databases were searched between January 2020 and June 2022.English-language studies, including at least four women with abnormal uterine bleeding. Eligible studies were assessed for risk of bias using the Newcastle-Ottawa Scale. Data synthesis was accomplished by meta-analysis of frequencies of the abnormal uterine bleeding rate and meta-regression of the rate adjusted for the type of vaccine and number of vaccinations. There were 12 eligible studies including a total of 1,132,613 women of whom 41,344 (31.3%, 95CI 11.7-55.1%) reported abnormal bleeding following vaccination. Nine studies included clinical presentation: the abnormality was menorrhagia in 38%, irregular menses in 28%, intermenstrual bleeding in 12% and delayed menses in 9%). There was considerable heterogeneity in results which could not be accounted for by the method of recording abnormal bleeding, vaccine manufacturer or number of doses. COVID-19 vaccine carries the inconvenience of abnormal uterine bleeding in almost one-third of the women vaccinated, mostly irregular menses or menorrhagia. In addition, the innovative vaccine mechanism could be used against various potential targets, further highlighting the need to assess vaccine side effects.
Types of Violence Prevalence in Medical Residencies in Mexico
Authors: Corona-Vázquez Teresita , Fajardo-Dolci Germán , Sánchez-Guzmán Alejandra , Paz-Rodríguez Francisco , Vives-Varela Tania , Hamui-Sutton Liz 
Published: January 2024

Abstract

Background. Violence includes behaviours that medical residents in clinical settings perceive as humiliating, abusive, or hostile. The aim of the present study is to describe the prevalence and severity of different types of violence in medical residencies administrated by the National Autonomous University of Mexico.
Method. The project was conducted through an analytical cross-sectional study, the sample included 78 specialties, 113 medical units, six health institutions and residents with between one and eight years of study during the 2021-2022. An online survey was applied, which demonstrated a high degree of reliability with an alpha omega Ω of 0.835 (CI; 0.828-0.843).
Results. Of the 14,751 students enrolled 12,612 (85%) responded, 49.6% were women, and the average age was 31.1 years (SD 3.1). A total of 6,602 respondents (52.3%) reported suffering some type of violence on the last 12 months. The incidences included psychological violence 44.4%, physical violence 4.7%, sexual violence 6%, and academic mobbing and workplace violence 32.7%. Professors and third-year residents were the most common perpetrators approximately 50% and 25% of the cases, respectively. Women reported suffering more violence than men (p< 0.05).
Conclusions. The strength of this study is based on the fact that it includes all medical specialties, it assesses the severity and direction of the violence, and it considers gender.
Real-time ultrasound-guided sacral plexus block combined with mild sedation for hemorrhoidectomy and hemorrhoidal artery ligation in a patient with amyotrophic lateral sclerosis: A case report
Authors: Li Yan , Wang Qian , Liu Taotao , Gao Min , Hu Qianhui 
Published: January 2024

Abstract

Patients with amyotrophic lateral sclerosis (ALS) present perioperative challenges for clinical anesthesiologists for anesthesia-associated complications. A 54-year-old woman with a 2-year history of ALS was scheduled for hemorrhoidectomy and hemorrhoidal artery ligation. We performed real-time ultrasound-guided sacral plexus block with dexmedetomidine under standard monitoring. The anesthesia method met the surgical demands and avoided respiratory complications during the procedures. There was no neurological deterioration after the surgery and 3 months after the patients were discharged. Real-time ultrasound-guided sacral plexus block combined with mild sedation may be an effective and safe technique in patients with ALS undergoing hemorrhoidectomy and hemorrhoidal artery ligation.
Research on the main controlling factors and preferred formulations for chemical oil recovery in conglomerate reservoirs based on complex lithology
Authors: Yan Xiaolong , Tian Yu , Shi Yongmin , Wang Xiaoguang , Leng Runxi , Zheng Haoxuan , Liang BaoXing , Zhao Shuai 
Published: January 2024

Abstract

It is found that the mineralogical composition of conglomerate oil reservoirs in the Junggar Basin in northwest China is complex compared to conglomerate oil reservoirs in other regions. Among them, the most active physicochemical properties are zeolite minerals and clay minerals, which have the largest specific surface, the highest zeta potential, and they readily interact with surfactants used in chemical oil recovery. Experiments were conducted according to the actual surfactant/polymer binary composite drive chemical oil recovery model at the production site, and the interfacial tensions of 17 surfactants were measured, and the anionic surfactant KPS petroleum sulfonate, the nonionic surfactant coconut oil fatty acid diethanolamide 6501, and the amphoteric surfactant octadecyl betaine, which achieved ultra-low interfacial tensions, were screened out. Using the core of conglomerate reservoir, the contained minerals and oil and water, three surfactants were tested for adsorption performance, wettability test, emulsification performance evaluation, and finally, after the oil drive validation experiments, it was concluded that the specific surface of the minerals, zeta potential and the amount of adsorption of the chemical agent are positively correlated, and the amount of adsorption affects the recovery rate of chemical drive in conglomerate reservoirs, so that the 6501 was recommended to be the preferred surfactant. The research methodology adopted in the paper can be applied to chemical drive in reservoirs of different types and rock mineral compositions, and is also constructive for the promotion of chemical drive in similar reservoirs.
Ethical concerns about artificial intelligence: Evidence from a national survey in Taiwan
Authors: Chang Wendy Li-Yun , Liao Ying-Kai , Chao En , Liu Shiang-Yao , Lee Tony Szu-Hsien 
Published: January 2024

Abstract
Ethical concerns about how artificial intelligence (AI) impacts individuals and society are increasing rapidly, but few studies have systematically investigated the public awareness of AI ethics. This reseach collected and analyzed data from a public poll in Taiwan, an Asian region with a developed economy and specific social conditions, to identify societal views on AI ethics. The analysis of 84 AI ethics guidelines worldwide provided the survey framework covering 5 ethical principles: transparency, fairness, privacy, nonmaleficence, and accountability. The overarching goal was to determine the commonalities and differences in the ethical concerns of Taiwanese laypersons toward AI. Participants aged from 20 to 70 (n = 1,200) completed a computer-assisted random-digit-dial telephone survey, which utilized ethical scenarios to capture social views, and item validity was confirmed using focus-group interviews. Results found that respondents concerned about nonmaleficence the most, emphasizing that AI applications should not harm humans. Taiwanese people therefore tended to support strict AI technology regulation. It was particularly interesting that different patterns of public concern emerged about accountability, with the opinions on attributing responsibility to stakeholders varying with scenarios and the public's backgrounds. Those with higher education levels tended to attribute more responsibility to the industry, whereas those who had only received elementary-school education attributed accountability to AI developers. For self-driving cars, accountability was attributed to AI developers, whereas for medical decision-making, the accountability was attributed to the hospitals. These findings may help to elucidate the associations between societal views and the ethical principles of AI worldwide.
Efficacy and Safety of Methylene Blue for Patients with Septic Shock A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Hu Yuwei , Li Jiyun , Zhang Hang , Yang Haoyue , Wang Yu , Ren Junyi , Sun Mingwei , Wang Xiaomei , Jiang Hua , Zeng Qin , Wang Kai 
Published: January 2024

Abstract
Objective To evaluate the efficacy and safety of intravenous Methylene Blue(MB) therapy in patients with septic shock.
Background Sepsis is a dysregulated host response to infection, with an abnormal nitric oxide metabolism among its characteristics. MB is a specific inhibitor of the inducible nitric oxide synthase and its downstream enzyme soluble guanylate cyclase. However, the efficacy and safety of MB in patients with septic shock are unclear.
Methods A comprehensive search of the Pubmed, EMBASE databases, Web of Science, Cochrane Library, and Chinese biomedical literature database was performed to identify randomized controlled trials that evaluated the effect of MB vs. placebo/blank in septic shock patients. The primary outcome was mortality within 28 days. The secondary outcomes were mean arterial blood pressure, lactate, mechanical ventilation time, the length of stay in the intensive care unit (ICU) and adverse effects.
Results Altogether, eight RCTs with a total of 387 participants were included in the meta-analysis, of whom 161 were randomized to receive the MB treatment, whereas 160 received a placebo or blank. The MB therapy significantly reduced mortality among patients with septic shock [relative risk (RR) = 0.72, 95% confidence interval (CI): 0.54 - 0.96]. However, in subgroup analysis, the reduction in mortality was only significant in the patients who received a low dose of intravenous MB administration(<5mg/kg) (RR= 0.60, 95% CI: 0.41 - 0.88) and not significant in the high dose group (≥5mg/kg) (RR= 1.06, 95% CI: 0.67 - 1.69). The MB group had an increased MAP, decreased Lactate, and reduced length of stay in ICU and a shorter mechanical ventilation time when compared with the control group. There were no significant differences in the adverse effects between the intervention and control groups.
Conclusions A low dose of intravenous MB administration (<5mg/kg) is a safe and efficacious therapy in reducing mortality in septic shock. For patients experiencing septic shock, Methylene Blue has been shown to significantly increase MAP, reduce serum Lactate levels, and shorten LOS in ICU and mechanical ventilation time.
Registration: The information for this meta-analysis is available in PROSPERO (CRD42023417385).
Transcriptomic Alterations in the Hippocampus and Prefrontal Cortex of Chronic Unpredictable Stress Rats Induced by Low-Intensity Pulsed Ultrasound.
Authors: Ren Siyu , Guo Zinan , Zhang Jinniu , He Yi , Sun Zuoli , Yang Jian 
Published: January 2024

Abstract

Neuromodulation techniques have shown promise in the treatment of depression. In our previous study, we demonstrated that low-intensity pulsed ultrasound stimulation (LIPUS), a novel noninvasive neuromodulation tool, effectively ameliorated depression-like behaviors in a rat model of depression. However, the underlying mechanisms of its therapeutic effect remain unclear. The present study aims to elucidate the relevant mechanisms through transcriptomic research. To induce depression-like phenotypes, rats were subjected to chronic unpredictable stress (CUS) for six weeks. Throughout these six weeks, LIPUS was administered daily to the CUS rats, utilizing a pulse repetition frequency of 200 Hz. The transcriptome expression profiles in the hippocampus and prefrontal cortex (PFC) were subsequently analyzed by RNA sequencing techniques. We found that the CUS rats exhibited 3,464 differentially expressed genes (DEGs) in the hippocampus and 1,781 DEGs in the PFC when compared to the control group. Ultrasound stimulation was able to reverse the expression of 592 genes in the hippocampus and 254 genes in the PFC. Functional analysis revealed a significant enrichment of DEGs related to oxygen carrier activity and sugar metabolism. Subsequently, the alterations in the top ten genes were validated using real-time quantitative polymerase chain reaction. The significant changes in the expression of hemoglobin subunit beta, growth hormone 1, and glucokinase were confirmed. The results suggest that LIPUS may ameliorate depression-related manifestations by regulating cerebral oxygenation and sugar metabolism processes in the brain.
Effects of Soil Nutrient Availability on Ectomycorrhizal Communities’ Distribution in Two Dipterocarps Species Under Normal and Elevated Atmospheric Carbon Dioxide
Authors: Bakray Nur Aqilah Mustafa , Azman Alia Shafini , Kin Thi Bee , Mansor Patahayah , Mohti Azian , Jamar Nur Hidayah , Zohari Ahmad Fitri , Said Mohd Nizam Mohd 
Published: January 2024

Abstract

This study explores the impact of increasing atmospheric carbon dioxide (CO2) levels on belowground communities in tropical rainforests, focusing on the relationship between soil nutrient availability and the distribution of ectomycorrhizal (ECM) fungi on two dipterocarps seedlings, Shorea leprosula and S.lepidota in Tekam Forest Reserves, Pahang. Using the Free Air Carbon Dioxide Enrichment (FACE) hexagon plot, the research compared two different CO2 levels at normal (control plot) and elevated (FACE plot) concentrations. In the elevated CO2 plot, only four ECM species were found compared to five in the control plot. Notably, Geastrum sp. was exclusive to the control plot, while Lactarius sp., Russula sp., Tomentella sp., and Cenococcum sp. were present in both plots, indicating adaptability to varying soil nutrient and CO2 conditions. Statistical analyses (DCA, PCA, CCA) revealed associations between ECM fungi and plant hosts, soil nutrient composition, and a combination of parameters. For instance, S. lepidota exhibited a preference for phosphorus in the control plot, while S. leprosula preferred higher carbon contents. Tomentella sp. and Cenococcum sp. showed strong associations with nitrogen and potassium, respectively, while Lactarius sp. and Russula sp. correlated with the C:N ratio. In conclusion, this study underscores the importance of understanding the intricate relationship among soil nutrient availability, ECM distributions, and elevated atmospheric CO2 in tropical rainforest ecosystems.
Controllable Synthesis of Organopolysilazane Composite Coatings and Their Role in Protecting Combustible Cartridge Cases
Authors: Wu Mengde , Xiao Zhenggang 
Published: January 2024

Abstract

A series of organopolysilazane (OPSZ) composite coatings were synthesized via a grafting reaction between OPSZ and epoxy resin, which were applied to protect the surfaces of combustible cartridge cases. The chemical compositions were characterized by Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy. The results of heat-resistance tests indicated that the optimum OPSZ composite coating could prevent combustible cartridge cases from burning for 175.56 s at 250°C. The glass transition temperatures (Tg) of the OPSZ composite coatings were dependent on the polymer structure and were in the range of 254.7–454.0°C. All of the coatings showed good thermal stability, with temperatures at which 50% weight loss occurred being greater than 600°C. The results indicated that the OPSZ composite coatings could effectively improve the heat resistance of combustible cartridge cases. Based on scanning electron microscopy images after salt water exposure tests and the water contact angle, the OPSZ composite coating could effectively improve the environmental adaptability of combustible cartridge cases. This study demonstrated that the ceramic precursor OPSZ, as a protective material, provides a novel way to fabricate various coatings to protect combustible cartridge cases from high temperatures, environmental humidity, and corrosive air.
Electrostatic Defectoscopy Method on Testing Water Interface in Dielectric Materials
Authors: Ivantsov Mikhail 
Published: January 2024

Abstract

Innovative development of a sensor is proposed that uses the principle of Fabry-Perot interferometer. Such a sensor is designed as some kind of contact mirror on which the tested object is placed. This is the same measuring mirror for detecting the high frequency polarization effect of water contained in the material being tested. In that case, the test object is additionally affected by an electrostatic field, which should change the polarization relaxation of water molecules. Since a change in polarization in electrostatic field occurs at the water interface, it is possible to register traces of water in the hidden defects of material. The electrostatic measurement method proposed here can be used to study the internal structure of dielectric materials.
Ni0.05Ti1.95Nb10O29: an advanced anode material for high-performance lithium-ion storage
Authors: chen xiuli , Su Mingru , Chen Xueli , Cui Pei , Zhou Yu , Ji Yunxuan , Zhang Panpan , Liu yunjian 
Published: January 2024

Abstract

Ti2Nb10O29 (TNO) has garnered significant research attention due to its high specific capacity and excellent safety features, positioning it as a promising anode material for lithium-ion batteries (LIBs). Nevertheless, its rate capability is significantly hampered by poor electronic and ionic conductivity. In this paper, Ni2+ doping has been first applied to address these issues. A series of Ni2+ doped TNO (Nix-TNO (x = 0.03, 0.05, 0.07) electrode materials have been prepared to unveil the effects of Ni2+ content. The experimental results unveil that Ni2+ doping maintains the Wadsley-Roth shear structure of TNO while augmenting the single-cell volume and introducing additional oxygen vacancies in TNO. This generates a wider diffusion path and more active sites for lithium ions (Li+). Besides, the introduction of Ni2+ can alter the conductive field distribution of TNO, giving rise to a much higher electronic conductivity of Nix-TNO. Among the synthesized Nix-TNO, Ni0.05-TNO shows the best electrochemical performance, demonstrating a reversible capacity of 306 mAh g–1 with a Coulombic efficiency of 91.46% in the first cycle at 0.1 C and 146.19 mAh g–1 at 10 C after 500 cycles.
Intermittent Multivariate Time Series Spindle Thermal Error Prediction under Wide Environmental Temperature Ranges and Diverse Scenario Conditions
Authors: Jia Guangjie , Zhang Xu , Shen Yijun , Huang Nuodi 
Published: January 2024

Abstract

As the integration of mechanical engineering and deep learning fields becomes increasingly intertwined, the application of experimental thermal error modeling in intelligent manufacturing has gained significant importance. In this paper, the issue of spindle thermal error is treated as a multivariate time series problem due to the thermal transfer characteristics. This study aims to address the challenge of modeling intermittent multivariate time series spindle thermal errors under a wide range of environmental temperatures and various operational scenarios. To tackle this challenge, a substantial volume of experimental data, capable of effectively reflecting the patterns of spindle thermal error variations, was collected through experiments conducted at multiple speeds and under various operational scenarios. Subsequently, the acquired thermal error data underwent intermittent multivariate time series transformation (IMTS) to suit the serialized deep learning model. The study introduces the Crossformer model into the field of thermal error modeling for the first time, which is a variant of the Transformer model. The Crossformer model exhibits remarkable adaptability to temporal aspects while effectively maintaining its focus on data features. Ultimately, this study resulted in the development of the IMTS-CrossformerR experimental thermal error model. Throughout the research, a comprehensive examination of various models was undertaken, including two traditional Transformer models, and other thermal error deep learning and machine learning models. The results indicate that the proposed model outperforms its counterparts across multiple model metrics and predictive capabilities. Particularly noteworthy is its substantial improvement in the Range (± 5) ratio of residual fluctuations reaching 95.7%, a key engineering metric. These findings emphasize the significant engineering application value of this research, offering novel methods and insights for the precise prediction of spindle thermal errors in the manufacturing industry.