bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect Of Administration Of Ferous Sulfas On Iron Deficiency Anemia And Iron Deficiency Anemia With Stunting Aged 6 – 72 Months In Pandeglang, Banten And Its Review From Islamic View
Authors: Lestari Denis Tri , Nedra Wan , Arsyad Muhammad 
Published: November 2023

Iron deficiency anemia (IDA) is the most significant factor indicating low public health. Iron deficiency can cause disturbances or obstacles to growth, so that is related to stunting. Giving iron preparations is one of the efforts to reduce the incidence of IDA. Therefore, this study was conducted to determine the impact of iron supplementation on ADB and ADB with stunting aged 6-72 months. Al-Qur'an it emphasizes the importance to pay attention inhealth, one of themis by trying to seek treatment. This type of research uses a quasi-experimental method with a One-Group Pretest-Postest research design and taking samples with total sampling. The sample of this study was 30 toddlers aged 6-72 months in Kadugadung, Pandeglang, Banten.Based on the results of the study, after supplementation there was an increase in height (p < 0.05), Hb, MCV, MCH and Ferritin values (p> 0.05). However, MCHC levels did not show an increase (p>0.05). Based on bivariate analysis using the chi-square on the relationship between ADB and stunting (p > 0.05). Giving iron supplementation to children with ADB has a significant impact on Hemoglobin, MCV, MCH, Ferritin levels and stunting. However, there is no significant relationship between IDA and the incidence of stunting in children aged 6 - 72 months in Pandeglang, Banten. According to Islam, paying attention to health is one of the important things in maintaining benefit, one of them by consuming nutritious food as a iron supplementation in children with ADB and stunting.
Hubungan Premenstrual Syndrome terhadap Perubahan Regulasi Emosi Mahasiswi Fakultas Kedokteran Universitas Yarsi Angkatan 2020 dan Tinjauannya Menurut Pandangan Islam
Authors: Arifin Ocylia Carnella , Trisiswati Maya , Marhamah Siti 
Published: November 2023

Premenstrual Syndrome (PMS) kumpulan gejala fisik, psikologis dan emosi yang terkait dengan siklus menstruasi wanita dimana gejala biasanya timbul 6-10 hari sebelum menstruasi dan menghilang ketika menstruasi dimulai. Sebagian besar wanita usia subur memiliki satu atau lebih gejala PMS disaat siklus menstruasi yang mereka alami. Gejala yang terjadi menjelang menstruasi diduga mengganggu aktivitas sehari-hari wanita saat menstruasi.Tingkat keparahan dan frekuensi gejala yang dialami pada mayoritas wanita bisa berbeda di antara masing-masing siklus. Saat mengalami Premenstrual Syndrome (PMS) terdapat gejala fisik dan suasana hati yang dialami oleh remaja, yaitu malas beraktivitas dan sulit dalam mengendalikan emosi. Saat emosi tersebut datang kepada seseorang maka diperlukan pengelolaan emosi dengan baik sehingga dapat berdampak positif dalam melaksanakan tugas, peka terhadap kata hati sehingga dapat mencapai tujuannya. Tujuan penelitian ini adalah untuk mengetahui hubungan Premenstrual Syndrome terhadap Perubahan Regulasi Emosi Pada Mahasiswi Fakultas Kedokteran YARSI Angkatan 2020 dan tinjauannya menurut pandangan Islam.
Pengaruh Aktivitas Rumah Tangga Sehari-Hari Terhadap Insidensi OA Genu pada Mahasiswa Fakultas Kedokteran Universitas Yarsi Angkatan 2019 dan Tinjauannya Menurut Islam
Authors: Subhan Dadang Hawari , Yuliardi Teguh , Istiwara Endy Muhammad 
Published: November 2023

Pendahuluan: Osteoarthritis merupakan suatu penyakit sendi degeneratif, terjadi akibat ausnya tulang rawan sendi secara progressif dan kronik. Osteoarthritis biasanya ditandai dengan adanya nyeri sendi dan hilangnya fungsi, walau memang terjadi variasi dalam temuan klinis dari asimtomatik sampai gejala yang sangat berat. Salah satu faktor risko terbesar OA merupakan kegiatan beban tinggi yang dilakukan secara terus menerus, yaitu olahraga. Akan tetapi, tidak hanya olahraga yang membutuhkan aktivitas fisik yang tinggi. Kegiatan rumah tangga seperti menyapu, mencuci piring, dan lain-lain juga merupakan kegiatan fisik yang mampu membebankan sendi, sehingga berpotensial terjadi OA. Salah satu sendi yang paling sering mengalami OA merupakan sendi lutut (genu). Kegiatan rumah tangga merupakan salah satu aktivitas fisik yang paling umum dilakukan di sekitar rumah, oleh seluruh anggota rumah tangga tersebut, termasuk salah satunya mahasiswa. Mahasiswa sebagai penerus bangsa seharusnya dilindingi dari ancaman seperti ini. Tujuan penelitian ini adalah untuk mengetahui pengaruh kegiatan rumah tangga terhadap insidensi OA pada mahasiswa kedokteran serta tinjauannya menurut Islam.Metode: Jenis penelitian ini berupa survey observasional dengan desain penelitian cross sectional. Kuesioner didistribusikan melalui google form dan dilakukan pada mahasiswa Fakultas Kedokteran Universitas Yarsi angkatan 2019 dengan jumlah sampel sebanyak 160 responden. Analisis data dilakukan secara univariat dan bivariat menggunakan uji regresi linear.Hasil: Rata-rata aktivitas rumah tangga didapatkan setinggi 714,25 METs, dengan rata-rata insidensi OA berdasarkan WOMAC sejumlah 5,81 poin dari maksimal 96 poin. Berdasarkan hasil uji statistik didapatkan p = 0.209 (p>0.05) yang menunjukkan bahwa tidak terdapat pengaruh yang signifikan dari aktivitas rumah tangga terhadap insidensi OA Genu pada mahasiswa Fakultas Kedokteran Universitas Yarsi angkatan 2019.Simpulan: Tidak terdapat pengaruh yang bermakna secara statistik antara aktivitas rumah tangga terhadap insidensi OA Genu.
Gambaran Pasien Varikokel yang Menjalani Operasi Palomo Procedure di Rumah Sakit Tentara Tk Ii Moh Ridwan Meuraksa Jakarta Periode Januari 2019 – Desember 2019
Authors: Rafikatami Hasna , Anas Kamal , Arsyad Muhammad 
Published: November 2023

Latar Belakang: Varikokel adalah dilatasi abnormal dari vena pada pleksus pampiniformis akibat gangguan aliran darah balik vena spermatika interna dan merupakan salah satu penyebab infertilitas pada pria. Operasi Palomo Prosedur merupakan salah satu terapi pilihan yang digunakan untuk terapi varikokel karena operasi ini lebih mudah dilakukan dan biaya yang lebih terjangkau. Penelitian ini bertujuan untuk mengetahui gambaran umum pasien varikokel di RS Tentara Tk II Moh Ridwan Meuraksa Jakarta periode Januari 2019 – Desember 2019. Menurut pandangan Islam, tindakan bedah medis diperbolehkan karena niat dan motivasi utamanya adalah pengobatan. Metode: Studi ini merupakan studi deskriptif dengan rancangan penelitian deskriptif retropspektif menggunakan data rekam medik 199 pasien varikokel. Populasi dan sampel dalam penelitian ini semua kasus varikokel yang menjalani operasi Palomo Procedure di Rumah Sakit Tentara Tk II Moh Ridwan Meuraksa Jakarta periode Januari 2019 – Desember 2019. Hasil: Hasil penelitian didapatkan menunjukkan bahwa semua kejadian varikokel ditemukan pada rentang usia 10 – 19 tahun dan varikokel bilateral ditemukan pada rentang usia 41 – 45 tahun. Varikokel kiri (96,98%), varikokel kanan (2,01%), dan varikokel bilateral (1%). Pekerjaan pasien varikokel pelajar (72,36%) dan TNI-AD (27,84%). Kesimpulan: Kesimpulan penelitian ini adalah semua kejadian varikokel banyak ditemukan pada rentang usia 10 – 19 tahun, dengan lokasi terbanyak varikokel kiri dan pekerjaan paling banyak merupakan pelajar. Prosedur Palomo paling banyak dilakukan dengan indikasi varikokel grade 2 dan 3. Teknik palomo procedure pada pasien varikokel menurut pandangan islam diperbolehkan karena niat dan motivasi utamanya adalah pengobatan.
How collections and reputation were built out of Tasmanian violence: thylacines (Thylacinus cynocephalus) and Aboriginal remains from Morton Allport (1830–1878)
Authors: Ashby Jack 
Published: November 2023

Through European colonization, First Nations peoples were subjected to systematic and violent actions to dispossess them of their land and sovereignty. In Tasmania, this involved government-sponsored bounties as well as militaristic and diplomatic efforts to remove Indigenous peoples from the landscape. At the same time, and using similar rhetoric, thylacines ( Thylacinus cynocephalus (Harris, 1808)) suffered similarly from settler colonists. Thylacines (also known as Tasmanian tigers or Tasmanian wolves) were the largest marsupial carnivores of modern times, but became extinct in the twentieth century. There are several parallels between the treatment and representation of thylacines and Indigenous Tasmanian people, and how their remains were traded. This allows for analysis of how the environmental and human costs of the colonial project were enmeshed with practices of natural history. A central figure in the export of both thylacines and Indigenous remains from Tasmania was Morton Allport (1830–1878). This paper shows that Allport actively built his scientific reputation by exchanging specimens for honours. It asks whether this was a widespread model for other colonial figures who may have used specimen-based philanthropy to develop a form of soft power through associations with respected institutions such as learned societies, universities and museums. Figures like Allport played the role of a type of colonial settler-intermediary, valued for providing privileged access to specimens to the metropole. Allport also worked to augment scientific work in Tasmania and the economic reputation of the colony, demonstrating that the development of social networks and scientific reputations of colonial figures were entwined with the status and success of the colonies themselves.
Comparison of continuous popliteal nerve blocks using lidocaine vs. bupivacaine infusions for ambulatory foot surgery: a randomized, double-blind, noninferiority trial
Authors: Echevarría Ghislaine , Altermatt Fernando R. , Miranda Pablo , Araneda Andrea , Corvetto Marcia , de la Fuente René , De la Cuadra Juan C. 
Published: November 2023

Background and objectivesContinuous sciatic popliteal nerve block effectively manages pain after ankle and foot surgery. Most studies on continuous infusion of local anesthetics by perineural catheters have been made with bupivacaine, levobupivacaine, and ropivacaine, but lidocaine has not been used. The main objective of this study was to compare the quality of analgesia, motor function, and side effects between lidocaine and bupivacaine infusions in bilateral continuous popliteal nerve blocks for foot surgery.MethodsThis was a prospective, double-blind, randomized, parallel-group, noninferiority study. We enrolled 70 patients undergoing bilateral foot or ankle surgery that could be performed under general anesthesia and continuous regional analgesia using sciatic popliteal nerve blocks. During their postoperative care, they were randomized into 2 groups: group lidocaine (lidocaine 0.5%, 5 ml/h) or group bupivacaine (bupivacaine 0.1%, 5 ml/h), administered through elastomeric pumps. The primary outcome was pain at 24 h after surgery, assessed by a verbal numeric rating scale (ranging from 0 to 10). A pre-specified non-inferiority margin of 1.5 was defined. Secondary outcomes were the degree of motor and sensitive block, total opioid use, and difficulties with pump or catheter management.ResultsThe mean postoperative pain at 24 h of surgery was 2.06 (95% bootstrap confidence interval bCI 1.29, 2.83) and 1.82 (95% bCI 1.02, 2.62) in the lidocaine and bupivacaine group, respectively. The upper limit of the 95% bCI for the mean difference between lidocaine and bupivacaine was 0.82, declaring non-inferiority. No differences in the postoperative rescue analgesia use and satisfaction with care were found. No differences in postoperative NRS, sensory block and motor block were seen between groups.ConclusionsLidocaine 0.5% and bupivacaine 0.1% provide similar postoperative analgesia through a sciatic popliteal catheter in ambulatory bilateral foot surgery patients.Clinical Trial Registrationhttps://clinicaltrials.gov/, identifier: NCT02121119
The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis
Authors: Kechagias Stylianos , Theodoridis Konstantinos , Broomfield Joseph , Malpartida-Cardenas Kenny , Reid Ruth , Georgiou Pantelis , van Arkel Richard J. , Jeffers Jonathan R. T. 
Published: November 2023

Modern orthopaedic implants use lattice structures that act as 3D scaffolds to enhance bone growth into and around implants. Stochastic scaffolds are of particular interest as they mimic the architecture of trabecular bone and can combine isotropic properties and adjustable structure. The existing research mainly concentrates on controlling the mechanical and biological performance of periodic lattices by adjusting pore size and shape. Still, less is known on how we can control the performance of stochastic lattices through their design parameters: nodal connectivity, strut density and strut thickness. To elucidate this, four lattice structures were evaluated with varied strut densities and connectivity, hence different local geometry and mechanical properties: low apparent modulus, high apparent modulus, and two with near-identical modulus. Pre-osteoblast murine cells were seeded on scaffolds and cultured in vitro for 28 days. Cell adhesion, proliferation and differentiation were evaluated. Additionally, the expression levels of key osteogenic biomarkers were used to assess the effect of each design parameter on the quality of newly formed tissue. The main finding was that increasing connectivity increased the rate of osteoblast maturation, tissue formation and mineralisation. In detail, doubling the connectivity, over fixed strut density, increased collagen type-I by 140%, increased osteopontin by 130% and osteocalcin by 110%. This was attributed to the increased number of acute angles formed by the numerous connected struts, which facilitated the organization of cells and accelerated the cell cycle. Overall, increasing connectivity and adjusting strut density is a novel technique to design stochastic structures which combine a broad range of biomimetic properties and rapid ossification.
Deciphering the age-dependent changes of pulmonary fibroblasts in mice by single-cell transcriptomics
Authors: Wu Rundong , Zhang Xiaowei , Zhang Xinyuan , Sun Lixiang , Xia Tian , Zhang Ling-Juan 
Published: November 2023

Background and objectives: The heterogeneity of pulmonary fibroblasts, a critical aspect of both murine and human models under physiological and pathological conditions, is well-documented. Yet, consensus remains elusive on the subtypes, lineage, biological attributes, signal transduction pathways, and plasticity of these fibroblasts. This ambiguity significantly impedes our understanding of the fibrotic processes that transpire in lung tissue during aging. This study aims to elucidate the transcriptional profiles, differentiation pathways, and potential roles of fibroblasts within aging pulmonary tissue.Methods: We employed single-cell transcriptomic sequencing via the 10x Genomics platform. The downstream data were processed and analyzed using R packages, including Seurat. Trajectory and stemness of differentiation analyses were conducted using the Monocle2 and CytoTRACE R packages, respectively. Cell interactions were deciphered using the CellChat R package, and the formation of collagen and muscle fibers was identified through Masson and Van Geison staining techniques.Results: Our analysis captured a total of 22,826 cells, leading to the identification of fibroblasts and various immune cells. We observed a shift in fibroblasts from lipogenic and immune-competent to fibrotic and myofibroblast-like phenotype during the aging process. In the aged stage, fibroblasts exhibited a diminished capacity to express chemokines for immune cells. Experimental validation confirmed an increase of collagen and muscle fiber in the aged compared to young lung tissues. Furthermore, we showed that TGFβ treatment induced a fibrotic, immunodeficient and lipodystrophic transcriptional phenotype in young pulmonary fibroblasts.Conclusion: We present a comprehensive single-cell transcriptomic landscape of lung tissue from aging mice at various stages, revealing the differentiation trajectory of fibroblasts during aging. Our findings underscore the pivotal role of fibroblasts in the regulation of immune cells, and provide insights into why age increases the risk of pulmonary fibrosis.
Safety and efficacy of Amplatzer duct occluder II and konar-MF™ VSD occluder in the closure of perimembranous ventricular septal defects in children weighing less than 10 kg
Authors: Yildiz Kaan , Narin Nazmi , Oksuz Sedef , Ozdemir Rahmi , Pamukcu Ozge , Baykan Ali , Ozyurt Abdullah , Bagli Sedat , Aktas Rasit , Safak Ikbal Nur , Atlan Muhammed Akif , Bayam Yunus Sezer , Karadeniz Cem 
Published: November 2023

IntroductionDevice closure of perimembranous ventricular septal defects (pmVSD) is a successful off-label treatment alternative. We aim to report and compare the outcomes of pmVSD closure in children weighing less than 10 kg using Amplatzer Duct Occluder II (ADOII) and Konar-MF VSD Occluder (MFO) devices.MethodsRetrospective clinical data review of 52 children with hemodynamically significant pmVSD, and sent for transcatheter closure using ADOII and MFO, between January 2018 and January 2023. Baseline, procedural, and follow-up data were compared according to the implanted deviceResultsADOII devices were implanted in 22 children with a median age of 11 months (IQR, 4.1–14.7) and weight of 7.4 kg (IQR, 2.7–9.7). MFO devices were implanted in 30 children with a median age of 11 months (IQR, 4.8–16.6) and weight of 8 kg (IQR, 4.1–9.6). ADOII were implanted (retrograde, 68.1%) in defects with a median left ventricular diameter of 4.6 mm (IQR, 3.8–5.7) and right ventricular diameter of 3.5 mm (IQR, 3.1–4.9) while MFO were implanted (antegrade, 63.3%) in defects with a median left ventricular diameter of 7 mm (IQR, 5.2–11.3) (p &gt; 0.05) and right ventricular diameter of 5 mm (IQR, 2.0, 3.5–6.2) (p &lt; 0.05). The procedural and fluoroscopy times were shorter with the MFO device (p &lt; 0.05). On a median follow-up of 41.2 months (IQR, 19.7–49.3), valvular insufficiency was not observed. One 13-month-old child (6.3 kg) with ADOII developed a complete atrioventricular heart block (CAVB) six months postoperative and required pacemaker implantation. One 11-month-old child (5.9 kg) with MFO developed a CAVB 3 days postoperative and the device was removed. At 6 months post-procedure, only one child with MFO still experiences a minor residual shunt. There was one arterio-venous fistula that resolved spontaneously.ConclusionBoth the MFO and ADOII are effective closure devices in appropriately selected pmVSDs. CAVB can occur with both devices. The MFO is inherently advantageous for defects larger than 6 mm and subaortic rims smaller than 3 mm. In the literature, our series represents the first study comparing the mid-term outcomes of MFO and ADOII devices in children weighing less than 10 kg.
Association between urinary sodium and circulating lipid levels: a Mendelian randomization study
Authors: Yuan Chi , Jing Peijia , Jian Zhongyu , Wei Xin 
Published: November 2023

BackgroundUrinary sodium was indicated to be associated with dyslipidemia, but inconsistent conclusions for this association exist across the present observational studies.ObjectivesThis study aimed to evaluate the causal association between urinary sodium and circulating lipid levels [low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein cholesterol (HDL-C)] through Mendelian randomization.MethodsUnivariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) with pleiotropy-resistant methods were performed. Data for urinary sodium were obtained from the genome-wide association study (GWAS) from 446,237 European individuals. Data for lipid profiles were extracted from GWAS based on the UK Biobank (for the discovery analysis) and the Global Lipids Genetics Consortium (for the replication analysis).ResultsIn the discovery analysis, UVMR provided evidence that per 1-unit log-transformed genetically increased urinary sodium was associated with a lower level of HDL-C level (beta = −0.32; 95% CI: −0.43, −0.20; p = 7.25E−08), but not with LDL-C and triglycerides. This effect was still significant in the further MVMR when considering the effect of BMI or the other two lipid contents. In contrast, higher genetically predicted triglycerides could increase urinary sodium in both UVMR (beta = 0.030; 95% CI: 0.020, −0.039; p = 2.12E−10) and MVMR analyses (beta = 0.029; 95% CI: 0.019, 0.037; p = 8.13E−10). Similar results between triglycerides and urinary sodium were found in the replication analysis.ConclusionIncreased urinary sodium may have weak causal effects on decreased circulating HDL-C levels. Furthermore, genetically higher triglyceride levels may have independent causal effects on increased urinary sodium excretion.
Undiagnosed diabetic retinopathy in Northeast China: prevalence and determinants
Authors: Zang Bo , Rong Shisong , Li Dong , Ding Xiaoxia , Zang Dongxiao , Wang Fenghua , Liang Yuanbo , Zhai Gang , Feng Kemi , Zhou Zixi , Wang Yu 
Published: November 2023

ObjectiveTo report the prevalence and contributing factors of undiagnosed diabetic retinopathy (DR) in a population from Northeastern China.Subjects/MethodsA total of 800 subjects from the Fushun Diabetic Retinopathy Cohort Study were enrolled. A questionnaire assessing incentives and barriers to diagnosis of DR was administered. Logistic regression was used to identify clinical and sociodemographic factors associated with undiagnosed DR. In a prespecified subgroup analysis, we divided patients into vision-threatening diabetic retinopathy (VTDR) and non-VTDR (NVTDR) subgroups.ResultsAmong 800 participants with DR, 712 (89.0%) were undiagnosed. Among 601 with NVTDR, 566 (94.2%) were undiagnosed. Among 199 with VTDR, 146 (73.4%) were undiagnosed. The risk factors affecting the timely diagnosis of NVTDR and VTDR exhibit significant disparities. In multivariate models, factors associated with undiagnosed VTDR were age over 60 years (OR = 2.966; 95% CI = 1.205-7.299; P = 0.018), duration of diabetes over 10 years (OR = 0.299; 95% CI = 0.118-0753; P = 0.010), visual impairment or blindness (OR = 0.310; 95% CI = 0.117-0.820; P = 0.018), receiving a reminder to schedule an eye examination (OR = 0.380; 95% CI = 0.163-0.883; P = 0.025), and the belief that “people with diabetes are unlikely to develop an eye disease” (OR = 4.691; 95% CI = 1.116-19.724; P = 0.035). However, none of the factors were associated with undiagnosed NVTDR (all P ≥ 0.145).ConclusionOur research has uncovered a disconcerting trend of underdiagnosis in cases of DR within our population. Addressing determinants of undiagnosed DR may facilitate early detection.