bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restenosis due to underexpansion of sirolimus‐eluting stent in a bifurcation lesion
Authors: Takebayashi Hideo , Kobayashi Yoshio , Dangas George , Fujii Kenichi , Mintz Gary S. , Stone Gregg W. , Moses Jeffrey W. , Leon Martin B. 
Published: November 2003

AbstractEven in the drug‐eluting stent era, percutaneous coronary intervention in bifurcation lesions is complex and technically demanding, and considerable expertise is required. This case report describes in‐stent restenosis due to stent underexpansion after kissing stents using sirolimus‐eluting stents. Catheter Cardiovasc Interv 2003;60:496–499. © 2003 Wiley‐Liss, Inc.
Balloon angioplasty of postoperative coarctation in the transverse arch in infants: Protecting the common carotid artery
Authors: Tomita Hideshi , Yazaki Satoshi , Kimura Kohji , Hayashi George , Fujita Hideki , Okada Yoko , Watanabe Ken , Kurosaki Ken‐ichi , Ono Yasuo , Yagihara Toshikatsu , Echigo Shigeyuki 
Published: November 2003

AbstractWe performed balloon angioplasty in three patients with postoperative coarctation in the transverse arch adjacent to the left common carotid artery. The age at arch reconstruction was 5, 6, and 2 days, while the interval between operation and balloon dilatation was 59 days, 87 days, and 12 months, respectively. Two balloons, one in the stenosis and the other in the left common carotid artery, were introduced over a wire sequentially and inflated simultaneously until the waist of the balloon in the arch disappeared. After balloon dilatation, a significant reduction in the peak‐to‐peak pressure gradient and an increase in vessel diameters were observed in all patients. Further growth of the transverse arch was documented at follow‐up in two patients. No aneurysm has been detected in any patients. We believe that placing a protective balloon in the neck vessel increases safety during balloon dilatation of coarctation in the transverse arch. Catheter Cardiovasc Interv 2003;60:529–533. © 2003 Wiley‐Liss, Inc.
Randomized study to compare balloon angioplasty and elective stent implantation in venous bypass grafts: The Venestent Study
Authors: Hanekamp Clara E.E. , Koolen Jacques J. , den Heijer Peter , Schalij Martin J. , Piek Jan J. , Bär Frits W.H.M. , De Scheerder Iwan , Bonnier Hans J.R.M. , Pijls Nico H.J. 
Published: November 2003

AbstractThe aim of the study was to compare acute and long‐term angiographic and clinical outcome of balloon angioplasty and elective stenting in de novo lesions in the body of a saphenous vein graft (SVG). A total of 150 patients, with de novo lesions in SVG, were randomly assigned to balloon angioplasty or elective Wiktor I stent implantation. The angiographic restenosis rate at 6‐month follow‐up was 32.8% in the balloon group and 19.1% in the stent group (P = 0.069). At 1‐year follow‐up, target vessel revascularization rate was 31.4% vs. 14.5% (P < 0.05), and event‐free survival was 60.0% vs. 76.3% (P < 0.05) for the balloon and stent group, respectively. Elective stent implantation in de novo SVG lesions is associated with a significant lower target vessel revascularization rate and a significant higher event‐free survival at 1‐year follow‐up as compared to balloon angioplasty. Catheter Cardiovasc Interv 2003;60:452–457. © 2003 Wiley‐Liss, Inc.
Delayed recovery of left ventricular function after recanalization of a chronic coronary occlusion
Authors: Werner Gerald S. , Betge Stefan , Küthe Friedhelm , Figulla Hans R. 
Published: November 2003

AbstractAn unusually prolonged course of recovery of severely impaired left ventricular (LV) function (EF 32%) was observed in a patient after recanalization of a chronically occluded LAD. Despite persistent vessel patency, LV function remained depressed for almost 2 years after the percutaneous transluminal coronary angioplasty until complete recovery (EF 82%) could be observed. The possibility of a delayed recovery should be considered when assessing new therapeutic strategies to improve LV function of chronically ischemic myocardium. Catheter Cardiovasc Interv 2003;60:491–495. © 2003 Wiley‐Liss, Inc.
Percutaneous transcatheter patent foramen ovale closure using the right internal jugular venous approach
Authors: Sader Mark A. , De Moor Michael , Pomerantsev Eugene , Palacios Igor F. 
Published: November 2003

AbstractPercutaneous transcatheter closure of a patent foramen ovale (PFO) is a therapeutic option in patients with paradoxical embolism. For patients in whom PFO closure is indicated when a femoral venous approach is not possible, we describe the successful closure of two PFOs using the right internal jugular venous approach. Catheter Cardiovasc Interv 2003;60:536–539. © 2003 Wiley‐Liss, Inc.
Migraine with aura related to the percutaneous closure of an atrial septal defect
Authors: Rodés‐Cabau Josep , Molina Carlos , Serrano‐Munuera Carmen , Casaldáliga Jaume , Alvarez‐Sabin José , Evangelista Arturo , Soler‐Soler Jordi 
Published: November 2003

AbstractWe report a case of a 31‐year‐old woman who presented migraine attacks with aura within the 48 hr after transcatheter closure of an atrial septal defect with the Amplatzer septal occluder device. The migraine attacks persisted for 3 months, and all examinations performed to rule out a thromboembolic origin of migraine were negative. Catheter Cardiovasc Interv 2003;60:540–542. © 2003 Wiley‐Liss, Inc.
Developmental segregation in the efferent projections to auditory hair cells in the gerbil
Authors: Rontal Daniel A. , Echteler Stephen M. 
Published: November 2003

AbstractThe auditory receptor epithelium of mammals receives efferent innervation from neurons within and surrounding the superior olivary complex of the brainstem (Warr [1975] J. Comp. Neurol. 161:159–181). Disruption of this pathway during early postnatal life, when olivocochlear axons are forming their final connections with auditory hair cells and nerve fibers, can lead to profound and permanent hearing impairments (Walsh et al. [1998] J. Neurosci. 18:3859–3869). Identification of the possible causes for this deterioration in auditory function requires a better understanding of the normal developmental interactions that occur between efferent axons and their target cells within the cochlea. To provide such information, we labeled developing efferent fibers at a constant location within the gerbil cochlea by using the fluorescent carbocyanine dye 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindo‐carbocyanine perchlorate (DiI). The terminal arbors of these neurons were then reconstructed by using digital confocal microscopy. By postnatal day (P) 2, the efferent arbors associated with inner hair cells (IHCs) and outer hair cells (OHCs) displayed distinctly different morphologies closely resembling those described for adult animals (Brown [1987] J. Comp. Neurol. 260:605–619). Unlike their mature counterparts, however, P2 efferent axons frequently branched to contact both types of auditory hair cells. Unexpectedly, between P4 and P6, both IHC and OHC efferent axons produced additional branches that crossed the tunnel of Corti to invade the OHC zone. By P8, all of these supernumerary connections were eliminated, yielding completely segregated efferent pathways to IHCs and OHCs. J. Comp. Neurol. 467:509–520, 2003. © 2003 Wiley‐Liss, Inc.
Isoform‐specific distribution of the plasma membrane Ca2+ ATPase in the rat brain
Authors: Burette Alain , Rockwood Julia M. , Strehler Emanuel E. , Weinberg Richard J. 
Published: November 2003

AbstractRegulation of cytoplasmic calcium is crucial both for proper neuronal function and cell survival. The concentration of Ca2+ in cytoplasm of a neuron at rest is 10,000 times lower than in the extracellular space, pointing to the importance of the transporters that extrude intracellular Ca2+. The family of plasma membrane calcium‐dependent ATPases (PMCAs) represent a major component of the Ca2+ regulatory system. However, little information is available on the regional and cellular distribution of these calcium pumps. We used immunohistochemistry to investigate the distribution of each of the four PMCA isoforms (PMCA1–4) in the rat brain. Each isoform exhibited a remarkably precise and distinct pattern of distribution. In many cases, PMCA isoforms in a single brain structure were differentially expressed within different classes of neurons, and within different subcellular compartments. These data show that each isoform is independently organized and suggest that PMCAs may play a more complex role in calcium homeostasis than generally recognized. J. Comp. Neurol. 467:464–476, 2003. © 2003 Wiley‐Liss, Inc.
Persistence of graded EphA/Ephrin‐A expression in the adult frog visual system
Authors: Bach Helene , Feldheim David A. , Flanagan John G. , Scalia Frank 
Published: November 2003

AbstractMany studies have demonstrated the involvement of the EphA family of receptor tyrosine kinases and their ligands, ephrin‐A2 and ‐A5, in the development of the temporonasal axis of the retinotectal/collicular map, but the role of these molecules in optic nerve regeneration has not been well studied. Noting that the characteristic gradients of the EphA/ephrin‐A family that are expressed topographically in the retina and tectum of embryonic chicks and mice tend to disappear after birth, we took as our starting point an analysis of EphA and ephrin‐A expression in leopard frogs (Rana pipiens and utricularia), species capable of regenerating the retinotectal map as adults. For the EphA family to be involved in the regeneration, one would expect these topographic gradients to persist in the adult or, if downregulated after metamorphosis, to be reexpressed after optic nerve injury. Using EphA3 receptor and ephrin‐A5 ligand alkaline phosphatase in situ affinity probes (RAP and LAP, respectively) in whole‐mount applications, we report that reciprocally complementary gradients of RAP and LAP binding persist in the optic tract and optic tectum of postmetamorphic frogs, including mature adults. EphA expression in temporal retinal axons in the optic tract was significantly reduced after nerve section but returned during regeneration. However, ephrin‐A expression in the tectal parenchyma was not significantly elevated by either eye removal, with degeneration of optic axons, or during regeneration of the retinotectal projection. Thus, the present study has demonstrated a persisting expression of EphA/ephrin‐A family members in the retinal axons and tectal parenchyma that may help guide regenerating fibers, but we can offer no evidence for an upregulation of ephrin‐A expression in conjunction with optic nerve injury. J. Comp. Neurol. 467:549–565, 2003. © 2003 Wiley‐Liss, Inc.
Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
Authors: Kronenberg Golo , Reuter Katja , Steiner Barbara , Brandt Moritz D. , Jessberger Sebastian , Yamaguchi Masahiro , Kempermann Gerd 
Published: November 2003

AbstractTo study how adult hippocampal neurogenesis might originate from the proliferation of stem or progenitor cells in vivo, we have used transgenic mice expressing green fluorescent protein (GFP) under the nestin promoter to identify these cells. Having described an astrocyte‐like type 1 cell with low proliferative activity, a characteristic morphology, vascular end feet, and passive electrophysiological properties, we focused here on the large population of nestin‐GFP‐expressing type 2 cells, which lack all these features. Type 2 cells were highly proliferative and showed signs suggestive of their involvement in the neuronal lineage. They could be subclassified by the absence (type 2a) or presence (type 2b) of a coexpression of the early neuronal marker doublecortin. A third type of proliferating cells was doublecortin positive but nestin‐GFP negative (type 3). We believe that type 2a, 2b, and 3 cells mirror a marker progression during earliest neuronal development. This view is supported by the increasing coexpression of the early granule cell‐specific marker Prox‐1. The low proliferative activity of type 1 cells showed little change over time or under “neurogenic interventions,” such as a challenge by environmental complexity (ENR) or voluntary physical activity (RUN). However, RUN led to a significant increase of type 2 cells labeled with the proliferation marker bromodeoxyuridine (BrdU). ENR did not cause increased cell proliferation or an increased number of BrdU‐labeled type 2 cells, but both ENR and RUN resulted in more newly generated cells lacking nestin‐GFP immunoreactivity and expressing Prox‐1. These findings allow us to break down what was broadly perceived as “proliferation” in earlier experiments into the relative contribution of several cell types, representing the earliest steps of neuronal development. J. Comp. Neurol. 467:455–463, 2003. © 2003 Wiley‐Liss, Inc.
Internal structure of the nucleus rotundus revealed by mapping cadherin expression in the embryonic chicken visual system
Authors: Becker Tanja , Redies Christoph 
Published: November 2003

AbstractThe nucleus rotundus is the largest nucleus of the avian thalamus. It is an important center of visual information processing and conveys information from the optic tectum to the ectostriatum in the telencephalon. The nucleus rotundus is generally believed to contain internal divisions processing information on color, form, motion, and looming of visual objects. The detailed arrangement of these internal divisions is unclear. Here, we map the expression of four classic cadherins (N‐cadherin, R‐cadherin, cadherin‐6B, and cadherin‐7), which are markers for specific functional gray matter divisions and their fiber connections in the vertebrate brain. Results show that each cadherin is expressed by one coherent part of the nucleus rotundus that is connected to other brain structures by fiber tracts expressing the same subtype of cadherin. Overall, the expression of the four cadherins encompasses almost the entire nucleus rotundus. The four cadherin‐expressing parts show different degrees of overlap. For example, the cadherin‐6B part and the cadherin‐7 part overlap extensively, whereas the R‐cadherin part and the cadherin‐6B part show little overlap and are partially complementary. Regions with shallow gradients of cadherin expression alternate with regions that show relatively abrupt changes in cadherin expression. At some points, changes of cadherin expression are also arranged in a pinwheel‐like fashion, alternating between clockwise and counterclockwise orientations. In general, these results are reminiscent of the organization of functional modules in the mammalian visual cortex. It is speculated that each domain of cadherin expression corresponds to a functional domain, which processes a specific stimulus feature. J. Comp. Neurol. 467:536–548, 2003. © 2003 Wiley‐Liss, Inc.
A twin‐star hyperchaotic attractor and its circuit implementation
Authors: Yang Xiao‐Song , Li Qingdu , Chen Guanrong 
Published: November 2003

AbstractA very simple 4D system with a twin‐star hyperchaotic attractor is presented in this letter. Computer simulation is given to visualize the attractor, and a simple circuitry is designed for system implementation. Copyright © 2003 John Wiley & Sons, Ltd.
Molecular analysis of antilipemic effects of FR218944, a novel vasopressin V1a receptor antagonist, in genetically diabetic db/db mice in comparison with pioglitazone and fenofibrate
Authors: Morita Masahiko , Ohkubo‐Suzuki Akiko , Takahashi Tokiko , Nagashima Akira , Sawada Yuki , Ohkawa Takehiko , Nishimura Shintaro , Kita Yasuhiro 
Published: November 2003

AbstractArginine vasopressin V1a receptor is highly expressed in liver. The aim of this article is to perform a molecular analysis of the effects of a novel nonpeptide V1a receptor (V1aR) antagonist, FR218944 (2‐methoxy‐N‐(2‐methyl‐1H‐benzimidazol‐4‐yl)‐4‐(2,3,4,5‐tetrahydro‐1H‐1‐benzazepin‐1‐yl‐carbonyl)benzamide methanesulfonate), on plasma glucose (Glu) and triglyceride (TG) levels in diabetic db/db mice in comparison with those of a peroxisome proliferator‐activated receptor γ (PPARγ) agonist, pioglitazone, and a PPARα agonist, fenofibrate. FR218944 significantly lowered the plasma TG level but not plasma Glu level after oral administration at 32 mg/kg twice a day for 2 weeks. On the other hand, 10 mg/kg pioglitazone significantly lowered both TG and Glu levels, and 10 mg/kg fenofibrate significantly lowered only the TG level. Significant weight gain was observed only with pioglitazone treatment. db/db mice had lower levels of hepatic V1aR mRNA than normal +/+ mice. The three compounds lowered the mRNA level further. FR218944 significantly raised mRNA levels of β‐oxidation enzymes, Acyl‐CoA oxidase and bifunctional enzymes (BFE). Pioglitazone significantly increased mRNA levels of all the tested enzymes for β‐oxidation and fatty acid synthesis. Fenofibrate significantly increased mRNA levels of Acyl‐CoA synthase and BFE for β‐oxidation and decreased the mRNA level of sterol regulatory element‐binding protein 1, which transactivates many enzymes for fatty acid synthesis. In conclusion, chronic administration of FR218944, a V1aR antagonist, would lower the plasma TG level by increasing energy consumption via upregulation of β‐oxidation enzymes. Furthermore, the compound expresses its antilipemic effect via a different gene‐regulatory pathway from pioglitazone and fenofibrate. FR218944 has the potential to become a new drug for hyperlipemia. Drug. Dev. Res. 60:241–251, 2003. © 2003 Wiley‐Liss, Inc.
Antileishmanial action of Tephrosia purpurea linn, extract and its fractions against experimental visceral leishmaniasis
Authors: Sharma Preeti , Rastogi Subha , Bhatnagar Sunita , Srivastava Janmejya K. , Dube Anuradha , Guru Purushottam Y. , Kulshrestha Dinesh K. , Mehrotra Bishan N. , Dhawan Bhola N. 
Published: November 2003

AbstractTephrosia purpurea (family: Fabaceae), which is used in traditional remedies for the treatment of febrile attacks, enlargement and obstruction of liver, spleen, and kidney, was found to have significant antileishmanial activity, and has been extensively fractionated to locate the abode of activity. A fraction (F062) obtained from N‐butanol extract of T. purpurea showed consistent antileishmanial activity at 50 mg/ kg × 5 days by oral route against Leishmania donovani infection in hamsters. Activity was further confirmed in a secondary model, i.e., Indian langur monkeys (Presbytis entellus). Thus, the fraction F062 from this plant possesses potential to produce significant antileishmanial activity by oral route without producing any toxic side effects. Drug. Dev. Res. 60:285–293, 2003. © 2003 Wiley‐Liss, Inc.
Modelling the effect of form and profile adjustments on channel equilibrium timescales
Authors: Doyle Martin W. , Harbor Jon M. 
Published: November 2003

AbstractA model for describing river channel proﬁle adjustments through time is developed and applied to a river responding to base‐level lowering in order to examine the effect of channel widening and downstream aggradation on equilibrium timescales. Across a range of boundary conditions, downstream aggradation controlled how quickly a channel reached equilibrium. Channel widening either increased or decreased the equilibrium timescale, depending on whether or not sediment derived from widening was deposited downstream. Results suggest that proﬁle adjustments are more important than channel width adjustments in controlling equilibrium timescales for a channel responding to base‐level lowering. Copyright © 2003 John Wiley & Sons, Ltd.
Gelifluction: viscous flow or plastic creep?
Authors: Harris Charles , Davies Michael C. R. , Rea Brice R. 
Published: November 2003

AbstractThis paper reports results from two scaled centrifuge modelling experiments, designed to simulate thaw‐related geliﬂuction. A planar 12° prototype slope was modelled in each experiment, using the same natural ﬁne sandy silt soil. However two different scales were used. In Experiment 1, the model scale was 1/10, tested in the centrifuge at 10 gravities (g) and in Experiment 2, the scale was 1/30, tested at 30 g. Centrifuge scaling laws indicate that the time scaling factor for thaw consolidation between model and prototype is N2, where N is the number of gravities under which the model was tested. However, the equivalent time scaling for viscous ﬂow is 1/1. If geliﬂuction is a viscosity‐controlled ﬂow process, scaling conﬂicts will therefore arise during centrifuge modelling of thawing slopes, and rates of displacement will not scale accurately to the prototype. If, however, no such scaling conﬂicts are observed, we may conclude that geliﬂuction is not controlled by viscosity, but rather by elasto‐plastic soil deformation in which frictional shear strength depends on effective stress, itself a function of the thaw consolidation process.Models were saturated, consolidated and frozen from the surface downwards on the laboratory ﬂoor. The frozen models were then placed in the geotechnical centrifuge and thawed from the surface down. Each model was subjected to four freeze–thaw cycles. Soil temperatures and pore water pressures were monitored, and frost heave, thaw settlement and downslope displacements measured. Pore water pressures, displacement rates and displacement proﬁles reﬂecting accumulated shear strain, were all similar at the two model scales and volumetric soil transport per freeze–thaw cycle, when scaled to prototype, were virtually identical. Displacement rates and proﬁles were also similar to those observed in earlier full‐scale laboratory ﬂoor experiments. It is concluded therefore that the modelled geliﬂuction was not a time‐dependent viscosity‐controlled ﬂow phenomenon, but rather elasto‐plastic in nature. A ﬁrst approximation ‘ﬂow’ law is proposed, based on the ‘Cam Clay’ constitutive model for soils. Copyright © 2003 John Wiley & Sons, Ltd.
Mechanisms of riverbank failure along the Arno River, central Italy
Authors: Dapporto Stefano , Rinaldi Massimo , Casagli Nicola , Vannocci Pietro 
Published: November 2003

AbstractRiverbanks along the Arno River have been investigated with the aims of deﬁning the main mechanisms of failure and retreat, their spatial distribution, and their causes. Geomorphological aspects were investigated by a reconnaissance of riverbank processes, for a number (26) of representative sites. Laboratory and in situ tests were then performed on a selected number of riverbanks (15). Based on the material characteristics, six main typologies of riverbanks have been deﬁned, with homogeneous ﬁne‐grained and composite banks representing the most frequent types. Slab‐type failures are the most frequent mechanism observed on ﬁne‐grained banks, while cantilever failures prevail on composite banks.The role of river stage and related pore water pressure distributions in triggering the main observed mechanisms of failure has been investigated using two different types of stability analysis. The ﬁrst was conducted for 15 riverbanks, using the limit equilibrium method and considering simpliﬁed hypotheses for pore water pressure distribution (annulment of negative pore pressures in the portion of the bank between low water stage and peak stage). Stability conditions and predicted mechanisms of failure are shown to be in reasonably good agreement with ﬁeld observations. Three riverbanks, representative of the main alluvial reaches of the river, were then selected for a more detailed bank stability analysis, consisting of: (a) deﬁnition of characteristic hydrographs of the reach with different return periods; (b) modelling of saturated and unsaturated ﬂow using ﬁnite element seepage analysis; and (c) stability analysis with the limit equilibrium method, by adopting pore water pressure values derived from the seepage analysis. The results are compared to those obtained from the previous simpliﬁed analysis, and are used to investigate the different responses, in terms of stability, to different hydrological and riverbank conditions. Copyright © 2003 John Wiley & Sons, Ltd.