bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between psychological stress and abnormal physical examination indictors in medical health workers: a cross-sectional study in a tertiary hospital
Authors: Li Na , Wang Yan , Dong Yijiao , Chen Xiaoxue , Zhang Bin , Wang Kejian , Sun Ying 
Published: January 2024

Abstract
Background: Medical health workers in the healthcare system play an essential role and face unique workplace stressors. But the impact of psychological stress on the physical health of medical staff has received less attention compared to the general population.
Methods: We retrospectively analyzed the Self-rating Depression Scale (SDS) questionnaires and blood testing results collected from 1963 medical health workers. Then, we performed multivariate ordinal logistic regression analysis using a backward stepwise selection strategy, in order to identify physical examination indicators that were significantly affected by depression.
Results: We found that depression severity measured by SDS index score was positively correlated with the levels of hemoglobin (P=0.041), platelet count (P=0.020), and uric acid (P=0.049), while negatively correlated with red blood cell count (P=0.041). Analyses on subgroups divided by age and sex indicated similar results.
Conclusion: Our study suggested the correlation between depression level and certain physiological indicators in healthcare professionals. To validate our findings, larger multi-center investigations are needed to improve the health and well-being of medical personnels.
Value of In-house Viral Transport Medium in Breaking the Bottlenecks for Viral Testing in Pakistan
Authors: Adnan Fareeha , Khursheed Nazia , Khan Moiz Ahmed , Khan Maira , Parveen Nazia , Khan Mariam Ashfaq 
Published: January 2024

Abstract

INTRODUCTION:
The viral burden of Pakistan has substantially increased over the past decade owing to several outbreaks and newly emerging viruses. In such scenario, maintaining a steady supply of the viral transport medium (VTM) for transporting clinical samples to the laboratory for viral testing is critical. To ensure an adequate supply during times of shortage, we prepared an in-house VTM and validated its capacity to preserve viral nucleic acids.
METHODS
We used Phosphate-buffered saline (PBS) supplemented with sterile glycerol and a combination of antibiotics viz. vancomycin, colistin sulphate, amphotericin B and trimethoprim lactate, for our VTM formulation. For stability, antimicrobial efficacy and sterility evaluation, representative samples from each batch were selected. To validate our VTM, we tested clinical nasal swab samples transported in commercially available (Copan Italia S.p.A.) and in-house VTM and compared both the media for viral nucleic acid recovery using Reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULTS
A satisfactory evaluation of in-house VTM in terms of stability, antimicrobial efficacy and sterility was obtained. A total of 239 nasal swabs were processed in both commercial and PBS VTM, out of which 61 samples (25.5%) transported in commercial VTM were positive whereas, 63 samples (26.4%) transported in PBS VTM turned out positive. A comparison of Ct values of samples that exhibited PCR positivity from both groups of VTM (n = 61), showed that 14.7% of samples from PBS VTM as compared to 21.3% of samples from commercial VTM had Ct values of less than 25. Whereas, more samples from PBS VTM (78.7%) as compared to commercial VTM (73.8%) exhibited Ct values of more than 30. No statistical significance was noted for these findings. Our results showed that PBS VTM exhibited 100% sensitivity, 98.9% specificity, 96.8% positive predictive value and 100% negative predictive value.
CONCLUSION
Our in-house prepared VTM was successfully validated and offers a readily available, cost-effective, and simpler to prepare alternative for diagnostic laboratories in low resource settings, for routine viral testing as well as in preparing for an impending outbreak.
A New Approach to Recognizing Double-Handed Sign Language with IRNCViT-MBTSO Algorithm
Authors: Vaidhya G. K. , Anand G. Paavai 
Published: January 2024

Abstract

Sign language is an effective communication tool to convey information to each other, that is a bridge to reduce the communication gap between deaf and dumb people. The word level sign language recognition is a challenging task due to the wide range of body gestures, unidentified signals and hand configuration. To overcome this issue, a novel Inverted Residual Network Convolutional Vision Transformer based Mutation Boosted Tuna Swarm Optimization (IRNCViT-MBTSO) algorithm is proposed for recognizing double-handed sign language. The proposed dataset is designed to identify different dynamic words and the predicted images are preprocessed to enhance the generalization ability of the model and improve image quality. The local features are extracted after performing feature graining and the global features are captured from the preprocessed images by implementing the ViT transformer model. These extracted features are concatenated to generate a feature map and are classified into different dynamic words using the Inverted Residual Feed Forward Network (IRFFN). The TSO algorithm tunes the parameters of the IRNCViT model that is responsible for handling high-dimensional problems and convergence issues. The Mutation operator is introduced in this optimization phase to escape local optimum issues while updating the position of tuna. The performance valuation of this proposed model is performed in terms of recognition accuracy, convergence and visual output of the dataset that showed the highest performance than other state-of-the-art methods.
Validation of a German Body Dysmorphic Disorder Screening Scale and Clinical Interview according to ICD-11 and DSM-5 in the General Population
Authors: Schüller Johanna Sabina , Ebert Mareike , Tavakoli Farahnaz , Stangier Ulrich , Ritter Viktoria 
Published: January 2024

Abstract

Background
Body dysmorphic disorder (BDD) is an impairing psychological disorder with a high prevalence in clinical and cosmetic surgery settings. In the new ICD-11, BDD is grouped with the obsessive-compulsive spectrum disorders and the diagnostic criteria are updated, largely corresponding with the DSM-5. Available diagnostic interviews and screening scales for BDD are not based on these current criteria. In this paper, a newly developed screening questionnaire (BDD-S) and structured clinical interview (BDD-CI) according to the ICD-11 and DSM-5 criteria were preliminarily validated.
Methods
The BDD-S and the BDD-CI cover all core BDD symptoms. Open-ended questions allow for the addition of qualitative information on affected body parts and behavioural and mental aspects. We determined the internal consistency and construct validity of the BDD-S and suggested a cutoff value. We assessed a subsample with the BDD-CI and estimated a prevalence. The BDD-S was translated into Farsi and applied to an Iranian sample. BDD-S scores, social anxiety symptoms, and general psychopathological impairment were compared between a German and an Iranian sample.
Results
Internal consistency of the BDD-S was excellent (ω = .92). A high correlation with the body dysmorphic concerns and moderate correlations with measures of other mental disorders supported good construct validity. We determined a cutoff value of 19 for balanced sensitivity and specificity (sensitivity = 0.92, specificity = 0.87, AUC = .94). We estimated a prevalence of 2.76% for the German sample. The cultural comparison showed that the BDD-S score was higher in the Iranian sample.
Conclusions
With the BDD-S, we developed an economic and versatile screening instrument based on current diagnostic criteria, to be followed up with the BDD-CI when applicable, to obtain a clinical diagnosis. In the next step, the measures must be validated in larger clinical samples.
Improved YOLOv5 aquatic real-time target detection model based on novel attention mechanism
Authors: Jiang Liubing , Mu Yujie , Che Li , Wu Yongman 
Published: January 2024

Abstract
As a pillar industry in coastal areas, aquaculture needs artificial intelligence technology to drive its economic development. In this paper, we proposed an improved YOLOv5 target detection model to achieve automated operation of the aquaculture industry. This model completes the computerized classification and detection of aquatic products, increases the industry's productivity, and fosters its economic development. To provide a foundation of data for training the model, this research creates a dataset comprising 15 species of marine products. An underwater image enhancement approach is suggested in the data preprocessing section to raise the dataset's quality. To enrich the dataset and bolster its features, mosaic data improvement is presented. The accuracy and speed of model prediction are significantly increased by integrating the SimAM attention mechanism and introducing the FReLU activation function in the network backbone section. The suggested model's superiority and efficacy are shown by the comparison and ablation experiments. The enhanced YOLOv5 target detection model's experimental results, which are verified by the mAP and FPS evaluation metrics, can achieve 0.953 and 203 frames per second. Compared to the base YOLOv5 network, the evaluation metrics improved by 0.067 and 48 frames per second, respectively. In summary, our method can quickly and accurately identify aquatic products and achieve real-time target detection of marine products, laying the foundation for developing automation systems in the aquaculture industry.
Pharmacological Efficacy of Ethanol Leaf Extract of Justicia secunda in Swiss Albino Mice Experimentally Infected with Plasmodium berghei
Authors: ADEYEMI Nasiru Ademola , ONIYE Sonnie , REKWORT Peter Ibrahim , YUSUF Abdullateef , WADA Yunusa , HUSSAINI Muhammad 
Published: January 2024

Abstract

Background
Plasmodium parasite that causes malaria has developed resistance to most antimalarial medications and this has prompted research on natural products. The plant, Justicia secunda, is domesticated in the tropical region of Africa, and is used for the treatment of anaemia and other debilities. We evaluated the antiplasmodial and immunomodulatory activity of ethanol leaf extract of J. secunda in mice experimentally infected with Plasmodium berghei.
Result
Ethanol leaf extract of Justicia secunda contains steroids, tannins, flavonoids, terpenoids, phenols, glycosides and carbohydrate as well as thirty (30) compounds with numerous pharmacological activities. The LD50 was above 5,000mg/kg with no mortality. A dose-dependent percentage suppression of P. berghei was observed in the curative test for the three doses respectively (53.13%, 60.71%, 71.21%). The suppressive test for ethanol leaf extract of J. secunda also showed a similar trend (52.2%, 62.16%, 75.18%). The ethanol leaf extract of J. secunda effectively prevented anaemia, reduced the level of ALT enzyme and also increased the level of TNF-α and IL-10 in the plasma of P. berghei-infected mice. It also significantly reduced the oxidative stress and vascular congestion in the liver of mice infected with P. berghei.
Conclusion
This study revealed that ethanol leaf extract of J. secunda could be utilized to treat infection caused by Plasmodium parasite and also ameliorate the pathogenesis of the disease.
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence
Authors: Mitra Joy , Dharmalingam Prakash , Kodavati Manohar M. , Guerrero Erika N. , Rao K. S. , Hegde Muralidhar L 
Published: January 2024

Abstract

TDP-43 mislocalization and aggregation are key pathological features of motor neuron diseases (MND) such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, existing overexpression animal models typically capture late-stage TDP-43 proteinopathies, leaving a gap in our understanding of early motor neuron-specific disease mechanisms during pre-symptomatic phases. We address this by generating a new endogenous knock-in (KI) mouse model using a combination of CRISPR/Cas9 and FLEX Cre-switch strategy for the conditional expression of a mislocalized Tdp-43∆NLS variant of mouse Tdp-43. This variant is either expressed conditionally in whole mice or specifically within the motor neurons. The mice exhibit loss of nuclear Tdp-43 with its concomitant cytosolic accumulation and aggregation in targeted cells, leading to increased DNA double-strand breaks (DSB), signs of inflammation and DNA damage-associated cellular senescence. Notably, unlike WT Tdp43 which functionally interacts with Xrcc4 and DNA Ligase 4, key DSB repair proteins in the non-homologous end-joining pathway, the Tdp-43∆NLS mutant sequesters them into cytosolic aggregates, exacerbating neuronal damage in mice brain. The mutant mice also exhibit myogenic degeneration in limb muscles and distinct motor deficits, consistent with the characteristics of MND. Our findings reveal progressive degenerative mechanisms in motor neurons expressing endogenous Tdp-43∆NLS mutant, independent of TDP-43 overexpression or other confounding etiological factors. Thus, this unique Tdp-43 KI mouse model, which displays key molecular and phenotypic features of Tdp-43 proteinopathy, offers a significant opportunity to further characterize the early-stage progression of MND and also opens avenues for developing DNA repair-targeted approaches for treating TDP-43 pathology-linked neurodegenerative diseases.
Associations between metal-metal interaction and the risk of hypertension: A case-control study in Chinese community-dwelling elderly
Authors: Li Meiyan , Duan Siyu , Wang Rui , He Pei , Zhang Zhongyuan , Dai Yuqing , Shen Zhuoheng , Chen Yue , Yang Huifang , Li Xiaoyu , Sun Jian , Zhang Rui 
Published: January 2024

Abstract
Background
Fewer studies have focused on the interaction of metal mixtures with hypertension, especially in Chinese community-dwelling elderly. In addition, the relationship between metals exposure and hypertension may be weakened or strengthened due to the presence of multiple chronic diseases in the elderly.
Methods
In this study, inductively coupled plasma mass spectrometry was used to detect the levels of 12 metals in the urine of 693 elderly people in the Yinchuan community. Conditional logistic regression model and restricted cubic spline analysis (RCS) were used to explore the association between urinary metal concentration and hypertension and dose-response relationship. Quantile g-computation and Bayesian kernel machine regression (BKMR) to analyze the association of individual urinary metal concentrations and metal mixtures with hypertension risk.
Results
Urinary concentrations of 12 metals (vanadium, iron, cobalt, zinc, copper, arsenic, selenium, molybdenum, cadmium, tellurium, thallium, and lead) were higher in the hypertension group than in the non-hypertension group. In the RCS models, the urinary concentrations of vanadium, iron, and lead showed a linear dose-response relationship with hypertension risk. Quantile g-computation analyses showed cadmium contributed the largest positive weights. The BKMR models showed that the positive slope of lead became steep at higher concentrations of urinary iron when the other three metals were at the median.
Conclusion
We found that exposure to metal mixtures was associated with the risk of hypertension and a significant positive interaction between urinary iron and lead. Further research is needed to confirm our findings and elucidate the underlying mechanisms of the interaction between metals and hypertension.
The Effects of Palliative Supportive Care on the Quality of Life of Women with Breast Cancer Related Lymphedema
Authors: Kaveh Vahid , Kargar Fatemeh , Torkashvand Zahra , Ghalichi Leila , Pirjani Pooneh , Heydari Heshmatolah 
Published: January 2024

Abstract
Purpose
Breast cancer-related lymphedema (BCRL) is a common complication that significantly impacts patient's quality of life (QOL). Consequently, it is crucial to provide a variety of services, including palliative care, to improve the overall QOL of patients. This study evaluates the effect of palliative care provided by the Iranian Cancer Control Center (MACSA) on enhancing the quality of life of women with BCRL.
Methods
A one-group interventional study with a before-and-after design was conducted from October 2019 to February 2021. This study focused on 57 women with unilateral upper BCRL. QOL was assessed using the QLQ-C30 and EORTC BR23-QLQ questionnaires before and one month after patients were provided a comprehensive supportive palliative care package, which included lymphotherapy and psychological care services.
Results
One month after receiving palliative care, there was a significant increase in the average scores on the functional scales of the QLQ-C30 and QLQ-BR23 questionnaires, as well as overall QOL, compared to the scores before receiving these services (p < 0.05). Furthermore, there was a notable reduction in the average scores on each symptom scale on both questionnaires one month after patients received palliative care services.
Conclusion
Palliative care has been proven to enhance QOL in patients with BCRL. Additionally, it plays a crucial role in promoting various aspects of well-being, including general health, individual and social functioning, mental health, physical capabilities, sexual performance, satisfaction with appearance, reduction of arm circumference, and a positive attitude toward the future.
Synergistic effect of boreal autumn SST over the tropical and South Pacific and winter NAO on winter precipitation in the southern Europe
Authors: Li Jianping , Tang Xinxin 
Published: January 2024

Abstract
We find a positive phase of meridional tripole pattern of boreal autumn sea surface temperature anomalies over the tropical and South Pacific (TSPT+) can persist into winter and have a synergistic effect with negative NAO (NAO-) on the amplitude and occurrence of winter precipitation in southern Europe (SEWP). This synergistic effect is attributed to the linear superposition and nonlinear effect of NAO- and TSPT+. The TSPT+ with NAO- occur can stimulate a greater amount of Rossby wave energy propagating to the North Atlantic and Europe (NAE) region than without NAO- occur, and thereby synergistically regulating circulation with NAO-. Thus, NAO- and TSPT+ have a synergistic effect on the northwest-southeast trending positive-negative-positive circulation over the NAE region. Driven by the intensified mean circulation, water vapor transports and storm activity over southern Europe is evidently strong, which is important to precipitation formation over southern Europe.
The adsorption performance, thermodynamic and kinetic model of high crystallinity Na-p zeolites prepared from oil shale ash for the waste water treatment
Authors: Zhang Xuejian , Wang Rui , Meng Fanping , Li Yongtao , Chen Jie , Gao Yusheng , Zhang Jinyi , Ai Weidong , Wang Kuishan , Zhang Chenyang , Mahadevan C. K. 
Published: January 2024

Abstract

The Na-p zeolite using oil shale ash (OSA) as raw material was synthesized by hydrothermal synthesis method. The effects of alkali concentration, acid concentration, crystallization temperature, and crystallization time on the formation of Na-p zeolite were studied. The optimal synthesis conditions for converting oil shale ash into Na-p zeolite are: acid leaching concentration is 10%, NaOH dosage is 7 g, crystallization temperature is 130℃ and crystallization time is 12 h. It is found that adding some coal fly ash to oil shale ash can improve the adsorption performance of zeolite materials. The specific surface and the crystallinity of zeolite prepared from OSA and coal fly ash (CFA) are greater than that of pure OSA. The absorbion experiment results indicate that the zeolite synthesized by adding coal fly ash to the oil shale ash own richer pore structure and higher adsorption efficiency for methylene blue (99.2%). The thermodynamic and kinetic processes of methylene blue adsorption by pure oil shale ash, zeolites synthesized from oil shale ash, and zeolites synthesized from oil shale ash with coal fly ash have been systematically studied. These results reveal that the zeolite synthesized in the present study with high absorption can be used as a promising material for the wast water treatment.
INF2, an oncogenic protein in hepatocellular carcinoma (HCC)
Authors: Wang Haibiao , Lin Man , Ye Fusang , Li Hong , Ye Meng , Wang Jie 
Published: January 2024

Abstract
Objectives
This study investigated the expression level of INF2 and its carcinogenic effects in hepatocellular carcinoma. In addition, the mechanism of INF2 in hepatocellular carcinoma was explored.
Materials and methods
We analyzed the expression of INF2 and its prognosis and even correlation with clinicopathological characteristics based on the public database and HCC samples. Cloning formation experiment and flow cytometry were used to analyze the effect of INF2 expression level on the growth of HCC cells. Cell scratch experiment and Transwell migration experiment were applied to determine the role of INF2 expression level in the migration ability of HCC cells. TIMER2.0 database and TCGA-LIHC database were used to analyze the correlation between INF2 and PD-L1 in HCC.
Results
INF2 is aberrantly high expression in HCC samples. And high INF2 expression is associated with overall survival, liver cirrhosis and pathological differentiation. In vitro HCC cell models, upregulated expression of INF2 triggers the proliferation and migration of the HCC cell, while knockout of INF2 could counteract this effect. Knockdown of INF2 inhibited the proliferation and migration of HCC in vitro may via suppressing the Drp1-mediated mitochondrial fission. Moreover, INF2 was positively correlated with PD-L1 in HCC.
Conclusions
INF2 is an oncogenic protein in hepatocellular carcinoma, and targeting to INF2 may be beneficial to HCC patients with high expression of INF2.
Bronchial mucous gland adenoma: a rare case report and literature review
Authors: Wan Wang , Ye Zhuo-Hong , Zeng Guo-Xiong , Wang Kang-Xian , Wang Ming-Jun , Deng Biao , Wang Xue-Feng , Liang Zhu , Wu Yan-Xia 
Published: January 2024

Abstract
Mucous gland adenoma (MGA) is a rare benign tumor originating from the tracheobronchial serous mucinous glands and ducts. Most cases of this tumor are central-type, with very few being peripheral-type. A PubMed search identified no more than five cases of peripheral-type MGA in the literature. This report describes a rare case of peripheral-type MGA and identifies some special pathological features. The patient underwent right lower lobectomy, and the lesion was completely removed by video-assisted thoracic surgery. Currently, a clear diagnosis of MGA cannot be made before surgery, and further cases must be accumulated for future clinical or basic research.