bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid screening of riot control agents using DART-TD-HRMS
Authors: Mörén Lina , Östin Anders , Larsson Andreas , Forsberg Julia , Wiktelius Daniel , Lindén Pernilla 
Published: February 2024

Abstract
Purpose
Riot Control Agents (RCAs) are chemicals used in law enforcement for non-lethal riot control and use in conflicts between states that violates the Chemical Weapons Convention. OPCW's Scientific Advisory Board has identified sixteen potential RCAs including capsaicinoids, CS, and CR. RCAs may be misused for criminal purposes, so methods for detecting such misuse are needed. This study therefore evaluates the feasibility of a rapid, high throughput screening method of RCAs on surfaces (particularly clothing surfaces) by Direct Analysis in Real Time with a thermal desorption unit coupled to high-resolution mass spectrometry (DART-TD-HRMS).

Methods
A broadly applicable method for detecting potential RCAs was developed and tested on cotton fabric samples sprayed with self-defence sprays from an in-house reference stock. The feasibility of detecting RCAs by direct analysis of surface wipe samples placed in the DART source was also investigated.

Results
The method detected all sixteen RCAs and contaminated clothing were successfully screened for active agents in a reference collection of self-defence sprays. A pilot study also showed that RCAs can be detected by holding a sample directly in front of the DART source.

Conclusion
DART-TD-HRMS enables rapid and simple screening of RCAs on fabric samples enabling a high sample throughput.
A New Method for Selective Extraction of Torularhodin from Red Yeast Using CO2-SFE Technique
Authors: Ambrico Alfredo , Larocca Vincenzo , Trupo Mario , Martino Maria , Magarelli Rosaria Alessandra , Spagnoletta Anna , Balducchi Roberto 
Published: February 2024

AbstractTorularhodin is a dark pink colored carotenoid belonging to the xanthophylls group that can be biologically synthesized by red yeasts, especially by Rhodotorula and Sporobolomyces genera. The growing interest in this molecule is due to its biological activities such as antioxidant, anticholesterolemic, anti-inflammatory, antimicrobial, and anticancer. To satisfy potential commercial markets, numerous methods have been proposed to develop a cost-effective and environmentally friendly downstream process for the purification of torularhodin. However, obtaining high purity products without resorting to the use of toxic solvents, which can leave residues in the final preparations, remains a major challenge. In this context, the present study aimed to develop a new efficient method for the isolation of torularhodin from the red yeast Rhodotorula strain ELP2022 by applying the extraction technique with supercritical CO2 (CO2-SFE) in two sequential steps. In particular, in the first step, the dried lysed biomass of yeast was subjected to the action of CO2 in supercritical conditions (CO2SC) as sole solvent for extraction of apolar carotenoids. In the second step, the residual biomass was subjected to the action of CO2SC using ethanol as a polar co-solvent for the extraction of torularhodin. Both steps were carried out at different operating parameters of temperature (40 and 60 °C) and pressure (from 300 to 500 bar) with a constant CO2 flow of 6 L min−1. Regardless of the operating conditions used, this method allowed to obtain an orange-colored oily extract and a red-colored extract after the first and second step, respectively. In all trials, torularhodin represented no less than 95.2% ± 0.70 of the total carotenoids in the red extracts obtained from the second step. In particular, the best results were obtained by performing both steps at 40 °C and 300 bar, and the maximum percentage of torularhodin achieved was 97.9% ± 0.88. Since there are no data on the selective recovery of torularhodin from red yeast using the SFE technique, this study may be a good starting point to optimize and support the development of industrial production of torularhodin by microbial synthesis. This new method can significantly reduce the environmental impact of torularhodin recovery and can be considered an innovation for which an Italian patent application has been filed. In a circular bioeconomy approach, this method will be validated up to a pilot scale, culturing the strain Rhodotorula spp. ELP2022 on low-cost media derived from agri-food wastes.
Graphical Abstract
Anti-inflammatory effects of α-humulene on the release of pro-inflammatory cytokines in lipopolysaccharide-induced THP-1 cells
Authors: Becker Lucas , Holtmann Dirk 
Published: February 2024

AbstractWhile acute inflammation is an essential physical response to harmful external influences, the transition to chronic inflammation is problematic and associated with the development and worsening of many deadly diseases. Until now, established pharmaceutical agents have had many side effects when used for long periods. In this study, a possible anti-inflammatory effect of the sesquiterpene α-humulene on lipopolysaccharide (LPS) induction was tested. Herein, human THP-1-derived macrophages were used and their pro-inflammatory interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β) cytokine release was measured by means of enzyme-linked immunosorbent assay. A dose-dependent effect of α-humulene on IL-6 release was observed at 0.5 and 100 µM α-humulene, with a maximum IL-6 inhibition of 60% compared to the LPS reference value after the addition of 100 µM α-humulene. TNF-α as well as IL-1β cytokine concentrations were not reduced by the addition of 0.5 and 100 µM α-humulene. This study suggests that α-humulene has potential as a promising natural alternative to established pharmaceuticals for the treatment of elevated IL-6 levels and chronic inflammation in humans.
How can procedural flowcharts support the development of mathematics problem-solving skills?
Authors: Chinofunga Musarurwa David , Chigeza Philemon , Taylor Subhashni 
Published: February 2024

Abstract
Supporting students’ problem-solving skills, solution planning and sequencing of different stages that are involved in successfully developing a meaningful solution to a problem has been a challenge for teachers. This case study was informed by reflective investigation methodology which explored how procedural flowcharts can support student mathematics problem solving in a senior Mathematical Methods subject in Queensland. The paper used thematic analysis to analyse and report on teachers’ perceptions of the utility of procedural flowcharts during problem solving as well as content analysis on how student-developed flowcharts can support their problem-solving skills. Results show that development of procedural flowcharts can support problem solving as it helps with integration of problem-solving stages.
Negative Consequences Experienced by Individuals with Gaming Disorder Symptoms: A Systematic Review of Available Longitudinal Studies
Authors: Düll Luca , Müller Astrid , Steins-Loeber Sabine 
Published: February 2024

Abstract
Purpose of Review
Gaming disorder (GD) is a growing concern for health policies worldwide. The aim of the research presented here was to review systematically negative consequences of symptoms of GD by focusing on longitudinal studies that considered the temporal order of the effects.

Recent Findings
A total of 48 longitudinal studies met the inclusion criteria. The analysis indicated that so far negative consequences of symptoms of GD pertaining to mental health, behavioural problems, social and interpersonal factors, psychological factors, and physical health have been investigated.

Summary
The most consistent finding is an association between symptoms of GD and depression. In addition, symptoms of GD are an important predictor for symptoms of GD in the future. For other domains, there are few studies and findings are mixed with several studies reporting no association with negative consequences. Future studies should further investigate negative consequences of gaming as well as moderating factors. Regarding prevention and intervention strategies, negative consequences can be addressed in motivational interventions to drive behaviour change.
A modified evolutionary reinforcement learning for multi-agent region protection with fewer defenders
Authors: Sun Siqing , Dong Huachao , Li Tianbo 
Published: February 2024

AbstractAutonomous region protection is a significant research area in multi-agent systems, aiming to empower defenders in preventing intruders from accessing specific regions. This paper presents a Multi-agent Region Protection Environment (MRPE) featuring fewer defenders, defender damages, and intruder evasion strategies targeting defenders. MRPE poses challenges for traditional protection methods due to its high nonstationarity and limited interception time window. To surmount these hurdles, we modify evolutionary reinforcement learning, giving rise to the corresponding multi-agent region protection method (MRPM). MRPM amalgamates the merits of evolutionary algorithms and deep reinforcement learning, specifically leveraging Differential Evolution (DE) and Multi-Agent Deep Deterministic Policy Gradient (MADDPG). DE facilitates diverse sample exploration and overcomes sparse rewards, while MADDPG trains defenders and expedites the DE convergence process. Additionally, an elite selection strategy tailored for multi-agent systems is devised to enhance defender collaboration. The paper also presents ingenious designs for the fitness and reward functions to effectively drive policy optimizations. Finally, extensive numerical simulations are conducted to validate the effectiveness of MRPM.
Differential degradation dynamics of λ-cyhalothrin in mineral and peat soils: a comparative study under laboratory condition
Authors: Ngaini Zainab , Rudy Cynthia , Farooq Saba , Henry Michelle Crystals , Chai Alvin 
Published: February 2024

AbstractDissipation kinetics of λ-cyhalothrin in mineral and peat soils of Semongok (mineral soil) and Sibu (peat soil) farms was investigated in a laboratory incubation experiment under different temperature and moisture conditions at normal and double application dosages. The soil was spiked with λ-cyhalothrin at 5 and 25 µg/g soil, respectively. The soil moisture content was adjusted to 20, 40, and 60% of field capacity and then incubated in three climatic chambers at 15, 25, and 35 °C. Samples were collected at 0, 7, 21, 42, 70, and 105 days and analysed by Gas Chromatography-Electron Capture Detector (GC-ECD). Pesticides from the soil were extracted via a facile-modified QuEChERS method. Recovery studies of λ-cyhalothrin in mineral and peat soils were carried out at 0.05, 0.1, 0.5 and 1.0 µg/g fortification levels. The percentage of recovered amount was in the range of 81.4–95.0% and 81.3–86.5% for mineral and peat soils, respectively which falls within the acceptable recovery range of 70.0–120.0%. Factors i.e., soil carbon content, moisture, temperature, and applied dosage that render the degradation of λ-cyhalothrin in mineral and peat soils were evaluated. Findings showed that faster λ-cyhalothrin degradation took place in soil that contained low organic carbon content (< 12%), low soil moisture (≤ 20%) and incubated under higher temperatures (≤ 35 °C). Degradation of λ-cyhalothrin was described by first-order kinetics in both mineral and peat soils at various conditions. Half-lives of λ-cyhalothrin in mineral soil were shorter compared to peat soil. This is due to its lower carbon content and lower soil organic matter availability. This study provides significant information to the agriculture industry and farmers on the important factors such as soil properties, environmental conditions and application dosage that will influence the fate of pesticides in soil.
Graphical abstract
Influence of compacting pressure on the electrical properties of ZnO and ZnO:Mn ceramics
Authors: Korsunska N. , Markevich I. , Stara T. , Polishchuk Yu. , Ponomaryov S. , Kozoriz K. , Tsybrii Z. , Melnichuk O. , Melnichuk L. , Venger E. , Khomenkova L. 
Published: February 2024

AbstractUndoped and Mn-doped ZnO ceramics were prepared from the powders compacted at different pressures and sintered in air at high temperature. Their structural, optical, light emitting and electrical characteristics as well as the distribution of chemical elements were studied. It was found that an increase in compacting pressure stimulates an increase in direct current conductivity in both undoped and doped samples. In the case of doped samples, this effect was accompanied by a decrease in the height of potential barriers at the grain boundaries. It is found that electron concentration in ceramic grains, estimated from the modelling of infrared reflection spectra, remained relatively constant. The analysis of luminescence spectra and spatial zinc distribution revealed that the increase in compacting pressure results in the accumulation of interstitial zinc at the grain boundaries forming channels with enhanced conductivity. These findings provide an explanation for the evolution of electrical properties of ceramic samples with compacting pressure.
Preliminary assessment of volatile organic compounds and hazardous gases dispersion at low winds: case study of Mellitah Gas Complex, Libya
Authors: Danna Abdulhamid B. M. , Haddar Mohamed , Djemel Hassene , Kallel Amjad , Baccar Mounir 
Published: February 2024

AbstractAir pollution from industrial areas has become really worrying especially for city dwellers. The plume dispersion emitted from industrial sources is subject to several factors: temperature and emission rate velocity, wind speed and direction, source height, and atmospheric stability. This study aimed to evaluate the applicability of the dispersion coefficients correlated within a Gaussian plume approach to an industrial source in Libya (Mellitah Gas Complex) under low and moderate wind speeds. To this end, we have developed a specific code based on the Gaussian method to study the dispersion of (1) Volatile Organic Compounds (VOCs) from oil storage tanks and condensate storage tanks, and (2) sulfur oxides (SOx) and nitrogen oxides (NOx) emitted by the flaring process through three stacks of 80 m height. The emissions from multisource points and their dispersion have been predicted at calm wind conditions and the flammability and danger-prone toxic zones have been delimited around the studied site. The obtained results reveal that the emissions, particularly generated at low and moderate wind speeds, induce a dispersion with high concentration levels in the area surrounding the industrial site. The VOCs critical concentration region indicates a real risk of flammability at low-speed wind and stable atmospheric condition, from a height of 5 m above the ground. In fact, the VOCs concentration reach the Flammability Inferior Limit value of 0.018 m3 VOCs/m3 and these concentrations, appearing in the form of a plume, extend downstream to approximately 1000 m. The dispersion of NOx and SOx emissions downwind from the stacks are enhanced by wind speed; nevertheless, at 2 m height from the ground, the levels could exceed the limit value of 0.125 mg/m3, especially under the condition of unstable and very unstable atmospheric classes. From our findings, we recommend continuous monitoring campaigns inside and around the complex of Mellitah to ensure an environmentally secure zone that respects safety and health guidelines. Furthermore, enhanced simulations based on hourly weather conditions for extended area would be of great interest to accurately assess the air quality index in the region.
STEMM unveiled: Female undergraduates’ journey through gendered stereotypes – A qualitative exploration
Authors: Phillips Matthew J. 
Published: February 2024

AbstractDespite significant progress in gender equality, pervasive gender stereotypes and discrimination persist worldwide. These ingrained perceptions, based on gender, contribute to the disadvantage experienced by women in multiple areas of their lives. This is especially evident in female professionals studying and working within male-dominated fields like Science, Technology, Engineering, Mathematics, and Medicine (STEMM), where the representation of women collectively amounts to less than 17% in Australia. Therefore, this study aimed to investigate how female undergraduate students in STEMM fields conceptualised gender-based stereotypes within their academic programs, and how these experiences shaped their outlook on being women in a field that defies traditional gender norms. Employing an exploratory qualitative approach grounded in the social constructionist, and feminist, perspectives, face-to-face semi-structured interviews were carried out with 13 female undergraduates in STEMM disciplines, aged between 19 and 43, from Australian universities. An inductive reflexive thematic analysis of the data led to the construction of four themes that contribute to the comprehension of how female undergraduates recognise and manage prevalent gender-based stereotypes during the early stages of their professional journeys. Participants recognised their gender and its related traits as a drawback to their presence in STEMM, and felt that these attributes did not align, leading to a sense of academic disadvantage. The prevalence of male supremacy within STEMM was acknowledged as originating from the embedded patriarchal system within these fields, granting undeserved advantages to male undergraduates, enabling them to perpetuate a narrative that solely favours them.
State-level differentials in COVID-19 fatality: exploring age and sex disparities in Malaysia’s pandemic experience
Authors: Teh Jane K. L. , Teo Kok Lay , Bradley David A. , Chook Jack Bee , Ang Woo Teck , Peh Suat-Cheng 
Published: February 2024

AbstractIssueCOVID-19 has resulted in mortality worldwide and exposed vulnerabilities in public health systems. Although countries have since transitioned to the endemic phase, it is nonetheless important to identify inequities within populations to improve public health strategies in light of another health crisis.PurposeThis study aims to offer deeper insights into the sex and age differentials in COVID-19 fatality across different states in Malaysia, from the pandemic’s start to the country’s transition to the endemic phase.MethodologyAnalyses utilized data on the number of COVID-19 cases and deaths in Malaysia from January 2020 until April 2022. Case fatality rate (CFR) was computed for each state based on sex and age groups, for four periods (January–December 2020, January–June 2021, July–December 2021, and January–April 2022). Principal component analysis (PCA) uncovered patterns in the data and produced a multivariate visualization of the COVID-19 fatality within Malaysia.FindingsFindings revealed heterogeneity in fatality and identified several vulnerable states, notably in the northern region (Kelantan, Perlis) and on the East Coast (Sabah, Sarawak). A sex disparity was apparent in Kelantan as the CFR among older females was higher than their male counterparts. Sabah exhibited relatively higher CFR among the child population from 2020 to 2021.ImplicationThe findings deepened our understanding of COVID-19 fatality complexity, providing recommendations for Malaysia’s government in preparing for future health crises. Malaysia’s case study offers lessons on the need to address regional disparities and implement targeted strategies to protect vulnerable subgroups.
Nutritional quality and microbial diversity of Chhurpe from different milk sources: an ethnic fermented food of high-altitude regions of the Western Himalayas
Authors: Choudhary Sahdev , Shanu Kumari , Hegde Athrinandan S. , Kesarwani Veerbhan , Kumar Raman , shankar Ravi , Devi Sarita , Srivatsan Vidyashankar 
Published: February 2024

AbstractChhurpe is a naturally fermented traditional dairy food of high altitude Western Himalayan region. They are generally prepared from cow or yak milk and are consumed during harsh winters. The present study was conducted to characterize the different Chhurpe samples traditionally prepared by the ethnic groups utilizing milk from different animal breeds such as cow, yak, Zomo (cow × yak), and Germo (Zomo × yak). Nutritional characterization revealed that 100 g of Chhurpe could completely meet the dietary protein requirements of children and adults with high concentrations of methionine and lysine. Tryptophan and valine were the limiting amino acids among all the Chhurpe samples. Palmitic, stearic, and oleic acids were the predominant fatty acids. The Chhurpe samples were a rich source of micronutrients such as calcium, iron, and zinc meeting above 70% of recommended dietary allowances (RDA) among children (3–10 years) and up to 20% RDA for adults. Culture-independent metagenomic analysis revealed that lactic acid bacteria were the predominant group, consisting of genera such as Lactobacillus, Leuconostoc, Lactococcus, and Streptococcus followed by acetic acid bacteria, mainly Acetobacter. At the species level, Lactobacillus delbrueckii was the abundant strain among all the Chhurpe samples. Species diversity was significantly higher in Chhurpe prepared from Zomo milk. Probiotic bacterial strains such as Lactobacillus helveticus, L. delbrueckii, L. brevis, and Leuconostoc mesenteroides were identified in the Zomo Chhurpe indicating their superior quality. The present study was an attempt to popularize Chhurpe and promote its wider consumption by highlighting its nutritional properties.
A new performance-based measure of personality functioning impairment: development and preliminary evaluation of reliability and validity
Authors: Natoli Adam P. , Rodriguez Chloe M. 
Published: February 2024

AbstractPersonality functioning impairment is at the center of many dimensional models of personality. Available measures of personality functioning impairment are limited to self-report, clinician-/informant-rated, and interview methods. Although researchers have begun investigating established performance-based instruments’ potential for assessing personality functioning impairment, administration and scoring of these instruments is complex and the latent variables they measure diverge from personality functioning impairment as described in the ICD-11 and the Alternative Model for Personality Disorders (AMPD) of the DSM. We address this absence by developing and psychometrically evaluating the Level of Personality Functioning Scale-Questionnaire-based Implicit Association Test (LPFS-qIAT). The LPFS-qIAT’s psychometric properties were evaluated across four studies, producing initial evidence supporting the new instrument’s reliability as well as its convergent, discriminant, and criterion-related validity. As the first performance-based measure of personality functioning impairment that aligns with the AMPD and, to a degree the ICD-11, that is easily administered, scored, and interpreted, the LPFS-qIAT shows potential to become a valuable tool in both research and clinical practice.