bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spezifische Leitfähigkeit, Strom‐Spannungs‐Kurven, Zersetzungs‐ und Polarisationsspannung geschmolzener berylliumorganischer Komplexsalze
Authors: Strohmeier W. , Haecker W. 
Published: September 2023

AbstractBerylliumorganische Komplexsalze der allgemeinen Formel MX · n · Be(C2H5)2, wobei M ein Alkalimetall oder eine quartäre Ammoniumgruppe und X ein Halogen oder Pseudohalogen bedeutet, haben bei 80°C eine spezifische Leitfähigkeit von X ∼ 10−2 bis 10−3.Die spezifische Leitfähigkeit dieser Komplexe in Toluol ist von der gleichen Größenordnung. Die Strom‐Spannungs‐Kurven der meisten dieser Komplexe zeigen eine Art „Anodeneffekt”︁. Die Zersetzungs‐ und Polarisationsspannungen in diesen Elektrolyten wurden gemessen, wobei die Zersetzungs‐spannungen, welche mit zunehmender Temperatur abnehmen, wesentlich größer sind als die Polarisations‐ spannungen
Infrarot‐ und ramanspektroskopische Untersuchungen an homologen und stellungsisomeren n‐Alkanderivaten. 5. Mitteilung: Über die Schwingungsspektren der sekundären Nitroalkane
Authors: Geiseler G. , Kessler H. , Fruwert J. 
Published: September 2023

AbstractEs wurden die Infrarot‐ und Ramanspektren der sich vom Propan, n‐Butan, n‐Pentan und n‐Octan ableitenden stellungsisomeren sekundären Nitroalkane untersucht und die vermessenen Banden bzw. Streulinien teilweise zugeordnet.
Untersuchung des Verbundverhaltens von CFK‐Spannlitzen in Beton mit faseroptischen Sensoren
Authors: Serrano‐Mesa María , Jesse Frank , Hückler Alex , Schlaich Mike 
Published: September 2023

AbstractCarbonfaserverstärkte Kunststoffe (CFK) eignen sich aufgrund ihrer hohen Zugfestigkeit und Korrosionsbeständigkeit als Bewehrung von Betonbauteilen, insbesondere als Spannglieder. Untersuchungen an der TU Berlin mit vorgespannten CFK‐Litzen im sofortigen Verbund zeigten, dass trotz Einhaltung einschlägiger Empfehlungen für die Betondeckung bereits bei moderaten Vordehnungen Spaltzugrisse im Beton auftreten können. In diesem Zusammenhang wurde das Verbundverhalten von vorgespannten Stahl‐ und CFK‐Litzen in Beton anhand von Spannkrafteinleitungsversuchen untersucht. Um die Übertragungslängen zuverlässig bestimmen zu können, wurden erstmals verteilte faseroptische Sensoren (Distributed Fibre Optic Sensors, DFOS) eingesetzt, die eine hoch ortsaufgelöste Dehnungsmessung liefern. Die Ergebnisse zeigen, dass in CFK‐Litzen aufgrund der hohen Zugfestigkeit signifikant höhere Verbundspannungen aktiviert werden, die zwar kürzere Übertragungslängen ermöglichen, aber zu vermehrter Spaltzugrissbildung führen können. Als wesentliche Einflussgrößen für Spaltrisse wurde neben der Betondeckung die Höhe der Vordehnung ermittelt. In diesem Aufsatz werden die durchgeführten Versuche detailliert beschrieben und die Versuchsergebnisse sowie die durch DFOS gewonnenen Erkenntnisse vorgestellt und diskutiert.
Insights into the antiosteoporotic mechanism of the soy‐derived isoflavone genistein: Modulation of the Wnt/beta‐catenin signaling
Authors: Mannino Federica , Imbesi Chiara , Irrera Natasha , Pallio Giovanni , Squadrito Francesco , Bitto Alessandra 
Published: September 2023

AbstractBone remodeling is a process that involves osteoblasts, osteoclasts, and osteocytes, and different intracellular signaling, such as the canonical Wnt/β‐catenin pathway. Dysregulations of this pathway may also occur during secondary osteoporosis, as in the case of glucocorticoid‐induced osteoporosis (GIO), which accelerates osteoblast and osteocyte apoptosis by reducing bone formation, osteoblast differentiation and function, accelerates in turn osteoblast, and osteocyte apoptosis. Genistein is a soy‐derived nutrient belonging to the class of isoflavones that reduces bone loss in osteopenic menopausal women, inhibiting bone resorption; however, genistein may also favor bone formation. The aim of this study was to investigate whether estrogen receptor stimulation by genistein might promote osteoblast and osteocyte function during glucocorticoid challenge. Primary osteoblasts, collected from C57BL6/J mice, and MLO‐A5 osteocyte cell line were used to reproduce an in vitro model of GIO by adding dexamethasone (1 μM) for 24 h. Cells were then treated with genistein for 24 h and quantitative Polymerase Chain Reaction (qPCR) and western blot were performed to study whether genistein activated the Wnt/β‐catenin pathway. Dexamethasone challenge reduced bone formation in primary osteoblasts and bone mineralization in osteocytes; moreover, canonical Wnt/β‐catenin pathway was reduced following incubation with dexamethasone in both osteoblasts and osteocytes. Genistein reverted these changes and this effect was mediated by both estrogen receptors α and β. These data suggest that genistein could induce bone remodeling through Wnt/β‐catenin pathway activation.
Synthesis, Theoretical, in Silico and in Vitro Biological Evaluation Studies of New Thiosemicarbazones as Enzyme Inhibitors
Authors: Erdoğan Musa , Serdar Çavuş M. , Muğlu Halit , Yakan Hasan , Türkeş Cüneyt , Demir Yeliz , Beydemir Şükrü 
Published: September 2023

AbstractEleven new thiosemicarbazone derivatives (1–11) were designed from nine different biologically and pharmacologically important isothiocyanate derivatives containing functional groups such as fluorine, chlorine, methoxy, methyl, and nitro at various positions of the phenyl ring, in addition to the benzyl unit in the molecular skeletal structure. First, their substituted‐thiosemicarbazide derivatives were synthesized from the treatment of isothiocyanate with hydrazine to synthesize the designed compounds. Through a one‐step easy synthesis and an eco‐friendly process, the designed compounds were synthesized with yields of up to 95 % from the treatment of the thiosemicarbazides with aldehyde derivatives having methoxy and hydroxy groups. The structures of the synthesized molecules were elucidated with elemental analysis and FT–IR, 1H‐NMR, and 13C‐NMR spectroscopic methods. The electronic and spectroscopic properties of the compounds were determined by the DFT calculations performed at the B3LYP/6‐311++G(2d,2p) level of theory, and the experimental findings were supported. The effects of some global reactivity parameters and nucleophilic‐electrophilic attack abilities of the compounds on the enzyme inhibition properties were also investigated. They exhibited a highly potent inhibition effect on acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) (KI values are in the range of 23.54±4.34 to 185.90±26.16 nM, 103.90±23.49 to 325.90±77.99 nM, and 86.15±18.58 to 287.70±43.09 nM for AChE, hCA I, and hCA II, respectively). Furthermore, molecular docking simulations were performed to explain each enzyme‐ligand complex's interaction.
Amino Acid Residues Controlling Domain Interaction and Interdomain Electron Transfer in Cellobiose Dehydrogenase
Authors: Motycka Bettina , Csarman Florian , Rupp Melanie , Schnabel Karoline , Nagy Gabor , Karnpakdee Kwankao , Scheiblbrandner Stefan , Tscheliessnig Rupert , Oostenbrink Chris , Hammel Michal , Ludwig Roland 
Published: September 2023

AbstractThe function of cellobiose dehydrogenase (CDH) in biosensors, biofuel cells, and as a physiological redox partner of lytic polysaccharide monooxygenase (LPMO) is based on its role as an electron donor. Before donating electrons to LPMO or electrodes, an interdomain electron transfer from the catalytic FAD‐containing dehydrogenase domain to the electron shuttling cytochrome domain of CDH is required. This study investigates the role of two crucial amino acids located at the dehydrogenase domain on domain interaction and interdomain electron transfer by structure‐based engineering. The electron transfer kinetics of wild‐type Myriococcum thermophilum CDH and its variants M309A, R698S, and M309A/R698S were analyzed by stopped‐flow spectrophotometry and structural effects were studied by small‐angle X‐ray scattering. The data show that R698 is essential to pull the cytochrome domain close to the dehydrogenase domain and orient the heme propionate group towards the FAD, while M309 is an integral part of the electron transfer pathway – its mutation reducing the interdomain electron transfer 10‐fold. Structural models and molecular dynamics simulations pinpoint the action of these two residues on the domain interaction and interdomain electron transfer.
Small Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase
Authors: Gorenflos López Jacob L. , Dornan Gillian L. , Boback Nico , Neuenschwander Martin , Oder Andreas , Kemnitz‐Hassanin Kristin , Schmieder Peter , Specker Edgar , Asikoglu Hatice Ceyda , Oberdanner Christian , Seyffarth Carola , von Kries Jens Peter , Lauster Daniel , Hinderlich Stephan , Hackenberger Christian P. R. 
Published: September 2023

AbstractUridine diphosphate N‐acetylglucosamine 2‐epimerase (GNE) is a key enzyme in the sialic acid biosynthesis pathway. Sialic acids are primarily terminal carbohydrates on glycans and play fundamental roles in health and disease. In search of effective GNE inhibitors not based on a carbohydrate scaffold, we performed a high‐throughput screening campaign of 68,640 drug‐like small molecules against recombinant GNE using a UDP detection assay. We validated nine of the primary actives with an orthogonal real‐time NMR assay and verified their IC50 values in the low micromolar to nanomolar range manually. Stability and solubility studies revealed three compounds for further evaluation. Thermal shift assays, analytical size exclusion, and interferometric scattering microscopy demonstrated that the GNE inhibitors acted on the oligomeric state of the protein. Finally, hydrogen‐deuterium exchange mass spectrometry (HDX‐MS) revealed which sections of GNE were shifted upon the addition of the inhibitors. In summary, we have identified three small molecules as GNE inhibitors with high potency in vitro, which serve as promising candidates to modulate sialic acid biosynthesis in more complex systems.
Acute fibrinous constrictive pericarditis and large pericardial effusion as the first manifestation of systemic lupus erythematsous disease in an adult male patient
Authors: Yousefi‐Koma Hannaneh , Jalalian Rozita , Bagheri Babak 
Published: September 2023

Key Clinical MessageSystemic lupus erythematosus (SLE) can have various manifestations. Although cardiac involvement is very common in SLE patients, a severe acute pericarditis as the first manifestation of SLE in a male patient is relatively rare. A 36‐year‐old male was admitted to our hospital with acute pericarditis, large circumferential fibrinous pericarditis, and major criteria of a high‐risk case of acute pericarditis. After a complete investigation, the underlying disease was revealed to be SLE. All of his symptoms were completely resolved after 6 weeks of treatment with non‐steroidal anti‐inflammatory drugs and corticosteroids with no need for a pericardiocentesis. Patients with acute fibrinous pericarditis should be considered and precisely investigated for multiorgan autoimmune process such as SLE, to avoid unnecessary intervention, and minimize the risk of recurrence and chronicity of the condition.
Thrombocytopenia and hyperthyroidism: A case report and literature review
Authors: Yingchoncharoen Pitchaporn , Abdelnabi Mahmoud , Thongpiya Jerapas , Hoffman Alexandra , Tariq Hira , Mittal Neha 
Published: September 2023

Key Clinical MessageImmune thrombocytopenic purpura (ITP) is very challenging to diagnose with concurrent comorbidities affecting platelet count including PAH and autoimmune thyroid disease. ITP resolution can be achieved with tailored treatment of the underlying conditions to avoid adverse events.AbstractImmune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a platelet count of <100 × 109/L in the absence of other causes of thrombocytopenia. It is classified as primary or idiopathic and secondary due to various coexisting conditions, including autoimmune thyroid diseases. It is especially challenging when the patient has comorbidities that affect platelet count easily, leading to anchoring bias. The first‐line treatment of ITP is corticosteroids, and it is also recommended to treat the primary causes of secondary ITP. Here, the authors report a case of secondary ITP in a patient with a recent diagnosis of Grave's disease and a history of idiopathic pulmonary hypertension with baseline chronic thrombocytopenia, possible mechanisms, and treatment strategies with a multidisciplinary approach.
Idiopathic high‐flow priapism in a 4‐month‐old infant: A case report and review of literature
Authors: Ahmed Faisal , Badheeb Mohamed , Al‐wageeh Saleh , Alyhari Qasem , Altam Abdulfattah , Ghabisha Saif 
Published: September 2023

Key Clinical MessageHigh‐flow priapism in pediatric population is rare, yet comprehensive clinical evaluation, along with penile Doppler ultrasound, and cavernosal blood analysis are crucial for accurate diagnosis. Conservative therapy is effective as an initial treatment.AbstractHigh‐flow priapism is considerably rare in the pediatric age group. We report a four‐month‐old infant presented with a prolonged penile erection. Diagnostic confirmation was achieved through the utilization of Doppler ultrasound and cavernous blood gas analysis. We also review published data on the management of this condition.
Presumed first episode of nonconvulsive status epilepticus as the cause of postoperative disorder of consciousness following the completion of general anesthesia: A case report
Authors: Tsuzuki Yumi , Ishida Yusuke , Tomino Mikiko 
Published: September 2023

Key Clinical MessageDisorder of consciousness can lead to irreversible sequelae without proper intervention. Consequently, early diagnosis and treatment are of paramount importance in patients with disorder of consciousness.AbstractDisorder of consciousness (DOC) has various etiologies. Here, we report a case in which DOC following general anesthesia was suspected as being due to the first episode of nonconvulsive status epilepticus (NCSE). An elderly man in his 80s underwent uneventful tumor resection surgery under general anesthesia for extramammary Paget's disease. After the procedure, he regained consciousness following anesthesia discontinuation and was extubated. Soon after extubation, however, although his respiratory status remained stable, his level of consciousness deteriorated to a Glasgow Coma Scale (GCS) score of E1V1M1. Head computed tomography and magnetic resonance imaging scans indicated no abnormal findings. Subsequently, involuntary movements were noted in his left upper limb. Suspecting an epilepsy episode, diazepam was administered, leading to an improvement in the level of consciousness (GCS: E4V5M6). Based on the improvement in consciousness after diazepam administration, we strongly suspected NCSE.
Sigmoid volvulus secondary to undescended testicle: Report of first case in the literatures
Authors: Ahmadinejad Mojtaba , Mammohammadi Alireza , Hajialigol Amirhossein , Tajik Armin , Maleki Hadi , Pak Haleh , Zebarjadi Bagherpour Javad 
Published: September 2023

AbstractSigmoid volvulus accounts for 20%–50% of colonic obstructions in Eastern countries. This occurs mostly in patients with a lack of mobility and a history of chronic constipation. There are some very known complications of a undescended intra‐abdominal testicle such as cancer, ischemia, and infertility; But the rotation of the colon around the spermatic cord of one UDT is a very rare phenomenon that there is no similar report. A 67‐year‐old man came to the emergency department with a complaint of abdominal pain and obstipation. On examination, patient was febrile (T: 38.5) and had mild general tenderness. According to the appearance of coffee beans in the X‐ray, the diagnosis of sigmoid volvulus was made. In the requested tests, leukocytosis was observed. Rectosigmoidoscopy was unsuccessful. The patient underwent laparotomy. After manual untwisting, a tubular structure at the base of the meso‐sigmoid was noticed. With further exploration, the testis was observed intra‐abdominally. Orchidectomy and sigmoidectomy were performed by Hartmann's method. Sigmoid volvulus is one of the common cases that surgeons frequently encounter. The case scenarios are often the same, and from experience, most cases result from a long meso and an elongated sigmoid secondary to prolonged constipation. Therefore, it is clear that a scrotal examination would not be part of the routine examination of a patient with sigmoid volvulus. In this article, by reporting a very rare etiology for a very common pathology, we tried to point out the importance of head‐to‐toe examination in all patients.
B(C6F5)3‐Catalyzed [2+3]‐Cyclative o,m‐diC‐H Functionalization of Phenols
Authors: Luo Jingyan , Luo Zhou , Zhang Biqi , Zhao Qiuyu , Liu Lu , Liu Yuanyuan 
Published: September 2023

AbstractMetal‐free catalytic C−H functionalization is highly desired for the construction of C−C bonds. We herein report a highly chemoselective consecutive C−H [2+3]‐cyclative functionalization for the simultaneous formation of two C−C bonds with construction of polycyclic phenols catalyzed by commercially available and low‐cost B(C6F5)3. This catalytic system tolerates a wide range of substrate scope, providing a series of 2,6,7,8‐tetrahydroacenaphthylen‐3‐ol‐type polycyclic compounds efficiently. Several derivatizations of the catalytic products have also been conducted to show the potential application of this method in synthesis of polycyclic compounds.
The role of temperature‐enhanced fault closure in promoting postinjection pressure diffusion and seismicity in enhanced geothermal systems
Authors: Ji Yinlin , Chen Yuedu , Hofmann Hannes , Zhang Yuan , Zang Arno , Zimmermann Günter 
Published: September 2023

AbstractPost shut‐in seismic events in enhanced geothermal systems (EGSs) occur predominantly at the outer rim of the co‐injection seismic cloud. The concept of postinjection fracture and fault closure near the injection well has been proposed and validated as a mechanism for enhancing post shut‐in pressure diffusion that promotes seismic hazard. This phenomenon is primarily attributed to the poro‐elastic closure of fractures resulting from the reduction of wellbore pressure after injection termination. However, the thermal effects in EGSs, mainly including heat transfer and thermal stress, may not be trivial and their role in postinjection fault closure and pressure evolution needs to be explored. In this study, we performed numerical simulations to analyze the relative importance of poro‐elasticity, heat transfer, and thermo‐elasticity in promoting postinjection fault closure and pressure diffusion. The numerical model was first validated against analytical solutions in terms of fluid pressure diffusion and against heated flow‐through experiments in terms of thermal processes. We then quantified and distinguished the contribution of each individual mechanism by comparing four different shut‐in scenarios simulated under different coupled conditions. Our results highlight the importance of poro‐elastic fault closure in promoting postinjection pressure buildup and seismicity, and suggest that heat transfer can further augment the fault closure‐induced pressure increase and thus potentially intensify the postinjection seismic hazard, with minimal contribution from thermo‐elasticity.
Multiscale landscape genetic analysis identifies major waterways as a barrier to dispersal of feral pigs in north Queensland, Australia
Authors: Ryan James , Prentis Peter J. , Fuller Susan 
Published: September 2023

AbstractFeral pigs (Sus scrofa) are a destructive and widespread invasive pest in Australia. An understanding of feral pig movement is required to develop management strategies to control feral pigs in Australia. Because landscape structure can have a strong influence on animal movement, it is important to determine how landscape features facilitate or impede the movement of feral pigs. Consequently, we conducted a landscape genetic analysis of feral pig populations in the Herbert region of far north Queensland, Australia, to determine management units and provide recommendations to better inform feral pig population control strategies. Using microsatellite data obtained from 256 feral pig samples from 44 sites, we examined feral pig population structure at multiple spatial scales for univariate and multivariate landscape resistance surfaces to determine the optimal spatial scale and to identify which of the nine landscape features tested impede or facilitate feral pig gene flow. Only weak genetic structure was found among the 44 sampling sites, but major waterways were identified as a minor barrier to gene flow, and an isolation by distance model was supported. We also found that highways facilitated gene flow across the study area, and this suggests that they may act as movement corridors or indicate translocation of feral pigs. Additionally, incorporating a second spatial scale enhanced the ability of our landscape genetics analysis to detect the influence of landscape structure on gene flow. We identified three management units based on natural barriers to gene flow and future targeted control should be undertaken in these management units to deliver sustained reduction of feral pig populations in the Herbert region. This study demonstrates how a landscape genetic approach can be used to gain insight into the ecology of an invasive pest species and be used to develop population control strategies which utilise natural barriers to movement.
Synthesis of bioethanol from mixed vegetable wastes: Experimental methodology and characterization
Authors: González‐Guerra Guillermo Manuel , Garate Ruiz José Ramón , Santos Tanamachi Kazuhiro , Restrepo‐Elorza María del Pilar , Gómez‐Castro Fernando Israel , Hernández Salvador , García‐García Juan Cristóbal , Gamiño‐Arroyo Zeferino 
Published: September 2023

AbstractBioethanol has been identified as a renewable product with high potential for application as biofuel. On the other hand, high volumes of agri‐food residues are generated daily. Such residues have potential as raw materials for industrial bioethanol production. There is a significant advance in the synthesis of biofuels from fruit and vegetable residues; however, most of the studies are focused on the conversion of a single type of raw material, limiting the application of the synthesis routes. This work presents a conversion methodology to produce bioethanol from carrot and broccoli residues and from their mixture; the samples of vegetable wastes has been collected in the municipality of Guanajuato, Mexico. Using the 1H NMR technique, the characteristic signals of bioethanol are identified. On the other hand, using the UV–VIS spectrophotometry technique, a maximum of 25.63 mg of total sugar content has been determined for the mixture. Likewise, a maximum bioethanol concentration of 60.6 g/L is obtained. From a refractometry and HPLC study, a conversion to bioethanol of 34.8% is determined for the mixture of residues. This work analyses the potential of broccoli and carrot residues for bioethanol production, either as isolated or as mixed wastes.