bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot trial of an online guided self-help cognitive behavioral therapy program for bulimia nervosa and binge eating disorder in Japanese patients
Authors: Ohsako Noriaki , Kimura Hiroshi , Hashimoto Tasuku , Hosoda Yutaka , Inaba Yosuke , Iyo Masaomi , Nakazato Michiko 
Published: November 2023

Abstract
Background
The purpose of this study was to develop an internet-based Guided Self-Help CBT (iGSH-CBT) for Bulimia Nervosa (BN) / Binge Eating Disorder (BED) for Japanese patients and to test its feasibility.

Methods
A single-arm feasibility study. After baseline assessment, patients underwent a 16-week iGSH-CBT program, our Japanese adaption of the European-based Salut BN program. During the treatment period, weekly email support from trained counselors was provided. Evaluations were performed at baseline, after 8 weeks, at the end of the 16-week intervention, and at 2 months after treatment had ended. The primary outcome measure was the change in the weekly frequency of objective binging. Secondary outcomes were the change in the weekly frequency of objective purge episodes, responses on self-report questionnaires of the frequencies of binging and purging, psychopathological characteristics of eating disorders found on BITE, EDE-Q, EDI-2, HADS and EQ-5D, measurements of motivation, and completion of intervention (vs. dropout).

Results
Participants were 9 female outpatients with BN (n = 5) or BED (n = 4), of whom 8 (88.9%) attended the assessment at the end of the 16-week intervention. Mean age was 28 years (SD = 7.9). Percent change of the weekly frequency of objective binging was -4.40%, and at the end of the 16-week intervention 25% of the participants had achieved symptom abstinence.

Conclusions
No adverse events were observed during the treatment period and follow-up, and the implementation and operation of the program could be performed without any major problems, confirming the feasibility of iGSH-CBT for BN and BED for Japanese patients. Although no significant change was observed in the weekly frequency of objective binging, the abstinence rate from bulimic behaviors of those who completed the assessments was 25.0% at the end of treatment, and the drop-out rate was 11.1%. iGSH-CBT may be an acceptable and possibly even a preferred method of CBT delivery for Japanese patients with BN or BED, and our Japanese adaptation of Salut BN seems feasible.

Trial registration
UMIN, UMIN000031962. Registered 1 April 2018 - Retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000036334
Exploring the known chemical space of the plant kingdom: insights into taxonomic patterns, knowledge gaps, and bioactive regions
Authors: Domingo-Fernández Daniel , Gadiya Yojana , Mubeen Sarah , Healey David , Norman Bryan H. , Colluru Viswa 
Published: November 2023

AbstractPlants are one of the primary sources of natural products for drug development. However, despite centuries of research, only a limited region of the phytochemical space has been studied. To understand the scope of what is explored versus unexplored in the phytochemical space, we begin by reconstructing the known chemical space of the plant kingdom, mapping the distribution of secondary metabolites, chemical classes, and plants traditionally used for medicinal purposes (i.e., medicinal plants) across various levels of the taxonomy. We identify hotspot taxonomic clades occupied by a large proportion of medicinal plants and characterized secondary metabolites, as well as clades requiring further characterization with regard to their chemical composition. In a complementary analysis, we build a chemotaxonomy which has a high level of concordance with the taxonomy at the genus level, highlighting the close relationship between chemical profiles and evolutionary relationships within the plant kingdom. Next, we delve into regions of the phytochemical space with known bioactivity that have been used in modern drug discovery. While we find that the vast majority of approved drugs from phytochemicals are derived from known medicinal plants, we also show that medicinal and non-medicinal plants do not occupy distinct regions of the known phytochemical landscape and their phytochemicals exhibit properties similar to bioactive compounds. Moreover, we also reveal that only a few thousand phytochemicals have been screened for bioactivity and that there are hundreds of known bioactive compounds present in both medicinal and non-medicinal plants, suggesting that non-medicinal plants also have potential therapeutic applications. Overall, these results support the hypothesis that there are many plants with medicinal properties awaiting discovery.
Infinitely many radial solutions of superlinear elliptic problems with dependence on the gradient terms in an annulus
Authors: Zhu Yan , Ma Ruyun , Su Xiaoxiao 
Published: November 2023

AbstractIn this paper, we are concerned with elliptic problems $$ \textstyle\begin{cases} -\Delta u= f(u)+ g( \vert x \vert ,u,\frac{x}{ \vert x \vert }\cdot \nabla u),&x\in \Omega , \\ u|_{\partial \Omega}=0, \end{cases} $$

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:

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is continuous, $|g(r,\xi _{0}, \xi _{1})|\leq C+\beta |\xi _{0}|$
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. We obtain infinitely many radial solutions with prescribed nodal properties using bifurcation techniques.
Post-traumatic growth and influencing factors among parents of premature infants: a cross-sectional study
Authors: Wang Fang , Zhang Shuo , Liu Chunyan , Ni Zhihong 
Published: November 2023

Abstract
Background
Post-traumatic growth is a positive psychological change that may aid recovery in individuals experiencing trauma. Owing to the lack of research in the area of parental care for premature infants, we decided to explore the levels and factors influencing post-traumatic growth among parents of premature infants in neonatal intensive care units. We believe that these findings will help reassess existing care practices so that healthcare providers can promptly identify negative emotions and take necessary measures to help develop the potential to enhance post-traumatic growth.

Methods
A cross-sectional survey was conducted using convenience sampling between February and September 2022. Data were analysed using independent sample t-tests and one-way analysis of variance (ANOVA). Bivariate correlations were analysed using the Pearson’s or Spearman’s method, and related factors were analysed using multiple linear regression. We followed the SRQR checklist throughout the study period.

Results
A total of 217 patients were effectively treated, with a recovery rate of 98.64%. Univariate analysis showed that the length of hospital stay, presence of only one child, parents’ age, marital status, education level, working status, and per capita monthly familial income were influencing factors. Bivariate analysis showed that post-traumatic growth was moderately and positively correlated with perceived social support, rumination, and family resilience. Multiple linear regression showed that purposeful contemplation, family resilience, education, family support, age, and marital status entered into the regression equation and together accounted for 47.4% of the total variation.

Conclusions
It is necessary to pay attention to post-traumatic growth and familial stability in these families, provide aid in building a good support system, and encourage parents to mobilise their family and favourable factors to increase post-traumatic growth levels.
In vitro evaluation of enzymatically derived blackcurrant extract as prebiotic cosmetic ingredient: extraction conditions optimization and effect on cutaneous microbiota representatives
Authors: Petrov Ivanković Anja , Milivojević Ana , Ćorović Marija , Simović Milica , Banjanac Katarina , Jansen Patrick , Vukoičić Ana , van den Bogaard Ellen , Bezbradica Dejan 
Published: November 2023

Abstract
Background
Blackcurrant is a rich source of polyphenols with proven physiological activity, that have lately been classified as emerging prebiotics, making its extracts suitable for application in functional food and bioactive cosmetics. However, these biomolecules are trapped in cell wall structures and nowadays, enzymatic hydrolysis is recognised as powerful tool for extraction efficiency improvement in an environmentally sound manner. This study aimed to optimize enzyme-assisted extraction to maximize yields of blackcurrant polyphenols. In addition, their prebiotic potential was tested by examining their influence on typical skin microbiota representatives as model microorganisms—beneficial coagulase-negative Staphylococcus epidermidis and two opportunistic pathogens, Staphylococcus aureus and Cutibacterium acnes.

Results
Among four examined commercial enzyme preparations, Viscozyme® L and Rohapect® MC, demonstrated the highest potential as extraction enhancers by increasing antioxidant activity, total polyphenol, and flavonoid contents. Furthermore, their synergetic effect enabled 95.3% increase in polyphenol concentration compared to conventional extraction with a maximum of 27.6 mg gallic acid equivalents (GAE)/g dry matter (DM) at a total enzyme concentration of 0.05 mL/g DM (Viscozyme® L to Rohapect® MC ratio 2:1) after 60 min. HPLC profiles of two samples showed differences in polyphenol composition indicating simultaneous extraction–biotransformation. At a concentration of 0.025 mg GAE/mL, PAS (prebiotic activity score) values were 0.096 and 0.172 for conventionally and enzymatically obtained extract, respectively. Moderate inhibitory effect of optimal extract concentration on Cutibacterium acnes was shown, as well. Hydrogel prepared with optimal extract concentration showed improved hydration effect, decreased irritability and increased dermatological compatibility comparing to basic formulation.

Conclusions
Overall results demonstrated that blackcurrant extract obtained under optimized conditions using enzymes possesses an emerging prebiotic potential for selective skin microbiota stimulation.

Graphical Abstract
Transforming writing education: WAC faculty experiences and challenges in Saudi universities
Authors: Alharbi Majed Abdullah , Albelihi Hani Hamd 
Published: November 2023

AbstractWriting across the curriculum (WAC) has been viewed as a movement that links several academic fields across various academic departments in different institutions. WAC has emerged as a powerful pedagogical tool for improving students’ learning outcomes and critical thinking. While the practice of WAC as an independent learning unit is not formally implemented in all Saudi universities, teaching writing across the disciplines is pervasive. The principal objective of this research project is to inform writing specialists and policymakers in Saudi higher education about the status of WAC on Saudi campuses. Through five faculty narratives and group interviews, this research collects and analyzes faculty experiences, challenges, perceptions, and institutional expectations concerning writing practices across the disciplines at predominantly undergraduate, teaching-oriented Saudi universities. Findings indicate that faculty members utilize WAC to encourage critical thinking and improve students’ overall linguistic competence. While instructors face challenges, participants reported the need to develop a community of practice to enhance WAC culture in Saudi Arabia. The study recommends that educators form cross-institutional teams to collectively design culturally sensitive, locally rooted, and responsive writing practices.
Comparison of the clinical and electrophysiological characteristics between type 1 and type 2 narcolepsy: a cross-sectional study
Authors: Niijima Kuniyuki , Wakai Masakazu 
Published: November 2023

Abstract
Introduction
Narcolepsy is a chronic brain disease characterized by excessive sleepiness and classified into two types based on the presence of cataplexy or reduced level of cerebrospinal fluid orexin-A (hypocretine-1): narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). These two types differ in symptoms other than cataplexy, as well as in certain examination findings. The present study aimed to investigate the clinical and electrophysiological characteristics of NT1 by comparing its features with those of NT2.

Methods
Subjects were 118 first diagnosed and untreated patients with narcolepsy. They underwent both polysomnography (PSG) and multiple sleep latency test (MSLT) as a sleep test. Diagnosis was established in accordance with International Classification of Sleep Disorders, Third Edition, and the type of narcolepsy was determined by the presence or absence of cataplexy, patients with cataplexy were diagnosed with NT1, and without cataplexy were diagnosed with NT2. We investigated characteristics of the patients, PSG and MSLT outcomes, and applied a suite of duly statistical analysis to account for each parameter.

Results
Among the 118 subjects, 35 patients (29.7%) were NT1, and 83 patients (70.3%) were NT2. Excessive daytime sleepiness which was measured by Japanese version of Epworth sleepiness scale (JESS) was significantly higher in NT1 than NT2. Furthermore, the presence of sleep hallucination (n = 29, 82.9%), sleep paralysis (n = 18, 51.4%), difficult maintaining sleep (n = 22, 62.9%), and sleep related movement and behavior disorders (n = 7, 20.0%) were significantly higher in NT1 than those in NT2. Additionally, parameters indicative of sleep fragmentation, such as the arousal index and wake time after sleep onset measured in PSG, exhibited a statistically significant increase in NT1 when contrasted with NT2.

Conclusions
Fragmentation of nocturnal sleep which is explained by the high arousal index and the long wake time after sleep onset on PSG was considered a characteristic finding of NT1 compared with NT2, and the patients with NT1 experienced greater difficulty of maintaining sleep. Concomitantly, the prevalence of NT1 in this study may be a representative value of the prevalence of NT1 among the patients with narcolepsy in Japan.
Risk of control failure to insecticides malathion, profenophos + cypermethrin mixture, and fipronil in boll weevil (Coleoptera: Curculionidae) populations from Bahia, Brazil
Authors: Coelho Beatriz S. , Leite Suzany A. , dos Santos Mateus P. , Guedes Raul N. C. , Bastos Cristina S. , Moreira Aldenise A. , Bonfim João E. V. , Castellani Maria A. 
Published: November 2023

Abstract
Background
To control the boll weevil Anthonomus grandis grandis (Coleoptera: Curculionidae), a key pest of cotton in the Americas, insecticides have been intensively used to manage their populations, increasing selection pressure for resistant populations. Thus, this study aimed to detect insecticide resistance and assess insecticide control failure likelihood of boll weevil populations exposed to malathion, profenophos + cypermethrin, and fipronil insecticides.

Results
Twelve populations of the boll weevil were collected from commercial cotton fileds of the state of Bahia, northeastern Brazil. These populations were exposed to malathion, profenophos + cypermethrin mixture, and fipronil, at their respective maximum label dose for field applications. Three replicates of 10 adult beetles were exposed to the insecticides and mortality was recorded after 24 h treatment. The control failure likelihood was determined after 48 h. Highest median lethal times (LT50) were observed for malathion and the profenophos + cypermethrin mixture. Resistance to at least one insecticide was detected in 11 populations; three populations were resistant to malathion and profenophos + cypermethrin; seven were resistant to all insecticides tested. The resistance levels were low (< 10-fold) for the three insecticides. Among 12 populations tested, 58% of them exhibited significant risk of control failure for the insecticides malathion and profenophos + cypermethrin. The insecticide fipronil was efficient for the control of the boll weevil in 83% of the populations.

Conclusions
The results confirm the significant risk of insecticide control failure in the boll weevil populations to the main compounds used in the region. Thus, proper insecticide resistance management plans are necessary for the boll weevil in the region, particularly for malathion and profenophos + cypermethrin insecticides.
Augmented dynamics of nonlinear systems: A review
Authors: Punetha Nirmal , Khatun Anjuman Ara , Jafri Haider Hasan , Prasad Awadhesh , Shrimali Manish Dev 
Published: November 2023

Abstract
We discuss a simple yet powerful control technique called “Linear Augmentation” (LA) for nonlinear dynamical systems. The linear augmentation can be perceived as a type of interaction that may occur naturally in dynamical systems as an environmental effect, or can be explicitly added to a system in order to control its collective dynamical behavior. LA has been known to effectively regulate resulting dynamics of various dynamical systems and can be used as a powerful control strategy in various applications. Examples include targeting attractor(s), regulating multistable dynamics, suppression of extreme events, and controlling chimera states in the nonlinear dynamical systems.
β Cell Stress and Endocrine Function During T1D: What Is Next to Discover?
Authors: Vived Celia , Lee-Papastavros Alexander , Aparecida da Silva Pereira Jéssica , Yi Peng , MacDonald Tara L 
Published: November 2023

Abstract
Canonically, type 1 diabetes (T1D) is a disease characterized by autoreactive T cells as perpetrators of endocrine dysfunction and β cell death in the spiral toward loss of β cell mass, hyperglycemia, and insulin dependence. β Cells have mostly been considered as bystanders in a flurry of autoimmune processes. More recently, our framework for understanding and investigating T1D has evolved. It appears increasingly likely that intracellular β cell stress is an important component of T1D etiology/pathology that perpetuates autoimmunity during the progression to T1D. Here we discuss the emerging and complex role of β cell stress in initiating, provoking, and catalyzing T1D. We outline the bridges between hyperglycemia, endoplasmic reticulum stress, oxidative stress, and autoimmunity from the viewpoint of intrinsic β cell (dys)function, and we extend this discussion to the potential role for a therapeutic β cell stress-metabolism axis in T1D. Lastly, we mention research angles that may be pursued to improve β cell endocrine function during T1D. Biology gleaned from studying T1D will certainly overlap to innovate therapeutic strategies for T2D, and also enhance the pursuit of creating optimized stem cell-derived β cells as endocrine therapy.
The Eighteenth-CenturyHôtel Particulier
Authors: Thompson Victoria E. 
Published: November 2023

AbstractThis article examines discussions of Parisian hôtels particuliers (townhomes) in eighteenth-century texts on architecture and mœurs (mores). It focuses on how exterior decoration was used to comment on the social order and on the relationship between public and private and shows how both were undergoing transformations in the eighteenth century. Exterior decoration meant to indicate the rank of the inhabitant was increasingly obscured by the practices of the wealthy, regardless of rank. The exterior of the townhome was a visible boundary between public (the street) and private (the home); it was also the entrance to residences that often combined private and public functions. Luxury townhomes housed government officials, some of whom bought their public offices. On the Right Bank, many townhomes were built by financiers, who lent privately held funds to the state. In written texts, multiple concerns about the instability of status and wealth focused on townhomes. These texts played a role in the articulation of a public realm completely differentiated from private ownership.
Le réseau d'affaires francophone dans la haute vallée de l'Ohio et le Kentucky entre 1783 et 1815
Authors: Deperne Marcel 
Published: November 2023

Précis
En 1787, l'Ordonnance du Nord-Ouest ouvre à la colonisation les immenses territoires situés à l'ouest des Appalaches. Un même esprit révolutionnaire, inspiré par les Lumières, s'empare au même moment des Etats-Unis et de la France et pousse migrants, exilés, et réfugiés à voir en la jeune république américaine un havre de paix et un pays de cocagne propice à l'accomplissement de leur « rêve américain ». Dans un monde en pleine mutation, ils partent donc, malgré leurs différences de parcours et de personnalité, avec le seul projet commun de « tenter la fortune ». « Français » venus de France ou d'autres pays francophones et réfugiés de Saint-Domingue forment une vaste nébuleuse composée d'individus isolés, anciens membres déçus des sociétés de colonisation, ou de commerçants, spéculateurs ou hommes d'affaires. Connectés aux réseaux des ports atlantiques, ils développent dans la haute vallée de l'Ohio et le Kentucky, région-carrefour et lieu de toutes les mobilités, un grand réseau d'affaires.
Moderate mass loss enhances flight performance via alteration of flight kinematics and postures in a passerine bird
Authors: Kou Guanqun , Wang Yang , Ge Shiyong , Yin Yuan , Sun Yanfeng , Li Dongming 
Published: November 2023

ABSTRACT
Many birds experience fluctuations in body mass throughout the annual life cycle. The flight efficiency hypothesis posits that adaptive mass loss can enhance avian flight ability. However, whether birds can increase additional wing loading following mass loss and how birds adjust flight kinematics and postures remain largely unexplored. We investigated physiological changes in body condition in breeding female Eurasian tree sparrows (Passer montanus) through a dietary restriction experiment and determined the changes in flight kinematics and postures. Body mass decreased significantly, but the external maximum load and mass-corrected total load increased significantly after 3 days of dietary restriction. After 6 days of dietary restriction (DR6), hematocrit, pectoralis and hepatic fat content, take-off speed, theoretical maximum range speed and maximum power speed declined significantly. Notably, the load capacity and power margin remained unchanged relative to the control group. The wing stroke amplitude and relative downstroke duration were not affected by the interaction between diet restriction and extra load. Wing stroke amplitude significantly increased after DR6 treatment, while the relative downstroke duration significantly decreased. The stroke plane angle significantly increased after DR6 treatment only in the load-free condition. In addition, the sparrows adjusted their body angle and stroke plane angle in response to the extra load, but stroke amplitude and wingbeat frequency remained unchanged. Therefore, birds can maintain and even enhance their flight performance by adjusting flight kinematics and postures after a short-term mass loss.