bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensuring greenhouse gas reductions from electric vehicles compared to hybrid gasoline vehicles requires a cleaner U.S. electricity grid
Authors: Singh Madalsa , Yuksel Tugce , Michalek Jeremy J. , Azevedo Inês M. L. 
Published: January 2024

AbstractEmissions from electric vehicles depend on when they are charged and which power plants meet the electricity demand. We introduce a new metric, the critical emissions factors (CEFs), as the emissions intensity of electricity that needs to be achieved when charging to ensure electric vehicles achieve lifecycle greenhouse gas emissions parity with some of the most efficient gasoline hybrid vehicles across the United States. We use a consequential framework, consider 2018 as our reference year, and account for the effects of temperature and drive cycle on vehicle efficiency to account for regional climate and use conditions. We find that the Nissan Leaf and Chevy Bolt battery electric vehicles reduce lifecycle emissions relative to Toyota Prius and Honda Accord gasoline hybrids in most of the United States. However, in rural counties of the Midwest and the South, power grid marginal emissions reductions of up to 208 gCO2/kWh are still needed for these electric vehicles to have lower lifecycle emissions than gasoline hybrids. Except for the Northeast and Florida, the longer-range Tesla Model S battery-electric luxury sedan has higher emissions than the hybrids across the U.S., and the emissions intensity of the grid would need to decrease by up to 342 gCO2/kWh in some locations for it to achieve carbon parity with hybrid gasoline vehicles. Finally, we conclude that coal retirements and stricter standards on fossil fuel generators are more effective in the medium term at reducing consequential electric vehicle emissions than expansion of renewable capacity.
Terahertz linear/non-linear anomalous Hall conductivity of moiré TMD hetero-nanoribbons as topological valleytronics materials
Authors: Shayeganfar Farzaneh , Ramazani Ali , Habibiyan Hamidreza , Rafiee Diznab Mohammad 
Published: January 2024

AbstractTwisted moiré van der Waals heterostructures hold promise to provide a robust quantum simulation platform for strongly correlated materials and realize elusive states of matter such as topological states in the laboratory. We demonstrated that the moiré bands of twisted transition metal dichalcogenide (TMD) hetero-nanoribbons exhibit non-trivial topological order due to the tendency of valence and conduction band states in K valleys to form giant band gaps when spin-orbit coupling (SOC) is taken into account. Among the features of twisted WS$$_2$$

2

/MoS$$_2$$

2

and WSe$$_2$$

2

/MoSe$$_2$$

2

, we found that the heavy fermions associated with the topological flat bands and the presence of strongly correlated states, enhance anomalous Hall conductivity (AHC) away from the magic angle. By band analysis, we showed that the topmost conduction bands from the ± K-valleys are perfectly flat and carry a spin/valley Chern number. Moreover, we showed that the non-linear anomalous Hall effect in moiré TMD hetero-nanoribbons can be used to manipulate terahertz (THz) radiation. Our findings establish twisted heterostructures of group-VI TMD nanoribbons as a tunable platform for engineering topological valley quantum phases and THz non-linear Hall conductivity.
Utilizing the power of plant growth promoting rhizobacteria on reducing mineral fertilizer, improved yield, and nutritional quality of Batavia lettuce in a floating culture
Authors: Ikiz Boran , Dasgan Hayriye Yildiz , Gruda Nazim S. 
Published: January 2024

AbstractIn soilless cultivation, plants are grown with nutrient solutions prepared with mineral nutrients. Beneficial microorganisms are very important in plant nutrition. However, they are not present in soilless culture systems. In this study we investigated the impact of introducing Plant Growth Promoting Rhizobacteria (PGPR) as an alternative to traditional mineral fertilizer in hydroponic floating lettuce cultivation. By reducing mineral fertilizers at various ratios (20%, 40%, 60%, and 80%), and replacing them with PGPR, we observed remarkable improvements in multiple growth parameters. Applying PGPR led to significant enhancements in plant weight, leaf number, leaf area, leaf dry matter, chlorophyll content, yield, and nutrient uptake in soilles grown lettuce. Combining 80% mineral fertilizers with PGPR demonstrated a lettuce yield that did not significantly differ from the control treatment with 100% mineral fertilizers. Moreover, PGPR application improved the essential mineral concentrations and enhanced human nutritional quality, including higher levels of phenols, flavonoids, vitamin C, and total soluble solids. PGPR has potential as a sustainable substitute for synthetic mineral fertilizers in hydroponic floating lettuce cultivation, leading to environmentally friendly and nutritionally enriched farming.
Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes
Authors: Liu Yinglei , Zhao Yamin , Zhang Siming , Rong Shen , He Songnian , Hua Liqi , Wang Xingdan , Chen Hongjian 
Published: January 2024

AbstractMitotic catastrophe (MC) is a novel form of cell death that plays an important role in the treatment and drug resistance of colon adenocarcinoma (COAD). However, MC related genes in COAD treatment and prognosis evaluation are rarely studied. In this study, the transcriptome data, somatic mutation and copy number variation data were obtained from The Cancer Genome Atlas (TCGA) database. The mitotic catastrophe related genes (MCRGs) were obtained from GENCARDS website. Differential gene analysis was conducted with LIMMA package. Univariate Cox regression analysis was used to identify prognostic related genes. Mutation analysis was performed and displayed by maftools package. RCircos package was used for localizing the position of genes on chromosomes. “Glmnet” R package was applied for constructing a risk model via the LASSO regression method. Consensus clustering analyses was implemented for clustering different subtypes. Functional enrichment analysis through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) methods, immune infiltration analysis via single sample gene set enrichment analysis (ssGSEA), tumor mutation burden and drug sensitivity analysis by pRRophetic R package were also carried out for risk model or molecular subtype’s assessment. Additionally, the connections between the expression of hub genes and overall survival (OS) were obtained from online Human Protein Atlas (HPA) website. Real-Time Quantitative Polymerase Chain Reaction (RT‑qPCR) further validated the expression of hub genes. A total of 207 differentially expressed MCRGs were selected in the TCGA cohort, 23 of which were significantly associated with OS in COAD patients. Subsequently, we constructed risk score prognostic models with 5 hub MCRGs, including SYCE2, SERPINE1, TRIP6, LIMK1, and EEPD1. The high-risk patients suffered from poorer prognosis. Furthermore, we developed a nomogram that gathered age, sex, staging, and risk score to accurately forecast the clinical survival outcomes in 1, 3, and 5 years. The results of functional enrichment suggested a significant correlation between MCRGs characteristics and cancer progression, with important implications for the immune microenvironment. Moreover, patients who displayed high TMB and high risk score showed worse prognosis, and risk characteristics were associated with different chemotherapeutic agents. Finally, RT‑qPCR verified the increased expression of the five MCRGs in clinical samples. The five MCRGs in the prognostic signature were associated with prognosis, and could be treated as reliable prognostic biomarkers and therapeutic targets for COAD patients with distinct clinicopathological characteristics, thereby providing a foundation for the precise application of pertinent drugs in COAD patients.
Geothermometry of calcite spar at 10–50 °C
Authors: Koltai Gabriella , Kluge Tobias , Krüger Yves , Spötl Christoph , Rinyu László , Audra Philippe , Honiat Charlotte , Leél-Őssy Szabolcs , Dublyansky Yuri 
Published: January 2024

AbstractCarbonate geothermometry is a fundamental tool for quantitative assessment of the geothermal and geochemical evolution of diagenetic and hydrothermal systems, but it remains difficult to obtain accurate and precise formation temperatures of low-temperature calcite samples (below ~ 40 to 60 °C). Here, we apply three geothermometry methods (∆47-thermometry, nucleation-assisted fluid inclusion microthermometry—hereafter NA-FIM—and oxygen isotope thermometry) to slow-growing subaqueous calcite spar samples to cross-validate these methods down to 10 °C. Temperatures derived by NA-FIM and Δ47-thermometry agree within the 95% confidence interval, except for one sample. Regression analyses suggest that the real uncertainty of ∆47-thermometry exceeds the 1 SE analytical uncertainty and is around ± 6.6 °C for calcite spar that formed at 10–50 °C. The application of δ18O thermometry was limited to a few samples that contained sufficient primary fluid inclusions. It yielded broadly consistent results for two samples with two other geothermometers, and showed higher temperature for the third spar. We also found that calcite with steep rhombohedral morphologies is characteristic of low temperatures (11–13 °C), whereas blunt rhombohedra prevail in the 10–29 °C domain, and the scalenohedral habit dominates > 30 °C. This suggests that the calcite crystal morphology can be used to qualitatively distinguish between low- and higher-temperature calcite.
Augmented drug combination dataset to improve the performance of machine learning models predicting synergistic anticancer effects
Authors: Liu Mengmeng , Srivastava Gopal , Ramanujam J. , Brylinski Michal 
Published: January 2024

AbstractCombination therapy has gained popularity in cancer treatment as it enhances the treatment efficacy and overcomes drug resistance. Although machine learning (ML) techniques have become an indispensable tool for discovering new drug combinations, the data on drug combination therapy currently available may be insufficient to build high-precision models. We developed a data augmentation protocol to unbiasedly scale up the existing anti-cancer drug synergy dataset. Using a new drug similarity metric, we augmented the synergy data by substituting a compound in a drug combination instance with another molecule that exhibits highly similar pharmacological effects. Using this protocol, we were able to upscale the AZ-DREAM Challenges dataset from 8798 to 6,016,697 drug combinations. Comprehensive performance evaluations show that ML models trained on the augmented data consistently achieve higher accuracy than those trained solely on the original dataset. Our data augmentation protocol provides a systematic and unbiased approach to generating more diverse and larger-scale drug combination datasets, enabling the development of more precise and effective ML models. The protocol presented in this study could serve as a foundation for future research aimed at discovering novel and effective drug combinations for cancer treatment.
Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni
Authors: de Souza Neto Lauro Ribeiro , Montoya Bogar Omar , Brandão-Neto José , Verma Anil , Bowyer Sebastian , Moreira-Filho José Teófilo , Dantas Rafael Ferreira , Neves Bruno Junior , Andrade Carolina Horta , von Delft Frank , Owens Raymond J. , Furnham Nicholas , Silva-Jr Floriano Paes 
Published: January 2024

AbstractSchistosomiasis is caused by parasites of the genus Schistosoma, which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for controlling schistosomiasis for over four decades, but despite that it is ineffective against juvenile worms and size and taste issues with its pharmaceutical forms impose challenges for treating school-aged children. It is also important to note that PZQ resistant strains can be generated in laboratory conditions and observed in the field, hence its extensive use in mass drug administration programs raises concerns about resistance, highlighting the need to search for new schistosomicidal drugs. Schistosomes survival relies on the redox enzyme thioredoxin glutathione reductase (TGR), a validated target for the development of new anti-schistosomal drugs. Here we report a high-throughput fragment screening campaign of 768 compounds against S. mansoni TGR (SmTGR) using X-ray crystallography. We observed 49 binding events involving 35 distinct molecular fragments which were found to be distributed across 16 binding sites. Most sites are described for the first time within SmTGR, a noteworthy exception being the “doorstop pocket” near the NADPH binding site. We have compared results from hotspots and pocket druggability analysis of SmTGR with the experimental binding sites found in this work, with our results indicating only limited coincidence between experimental and computational results. Finally, we discuss that binding sites at the doorstop/NADPH binding site and in the SmTGR dimer interface, should be prioritized for developing SmTGR inhibitors as new antischistosomal drugs.
3-D real-time ultrasound tracking of acoustically actuated swimming microdrone
Authors: Chen Qiyang , Liu Fang-Wei , Cho Sung Kwon , Kim Kang 
Published: January 2024

AbstractManeuverable microswimmers/microdrones that navigate in hard-to-reach spaces inside human bodies hold a great potential for various biomedical applications. Acoustically actuated microswimmers have already demonstrated feasibility. However, for eventual translation of this technology, a robust 3-D tracking strategy for the microswimmer is particularly required. This paper presents our lab-designed 3-D ultrasound tracking system for real-time tracking of an acoustically actuated 3-D swimming microdrone. The ultrasound tracking system utilizing two ultrasound probes, a step motor and a host controller, was built to track the 3-D arbitrary motion of the microdrone in real-time. The performance of tracking was evaluated in the benchtop experiments by comparing the reconstructed trajectories with synchronized camera recordings. The ultrasound tracking system showed high reliability, with an average error of less than 0.3 mm across six different trials when compared to camera tracking. The results demonstrated the capability of our lab-designed 3-D ultrasound tracking system in accurately tracking the undetermined motion of the acoustic actuated 3-D swimming microdrone in real-time. The developed tracking system holds promise as a potential approach for biomedical applications and could pave the way for future clinical translation of the microswimmer technology.
Reduction in the Free Androgen Index in Overweight Women After Sixty
Days of a Low Glycemic Diet
Authors: Zapała Barbara , Marszalec Patrycja , Piwowar Monika , Chmura Olaf , Milewicz Tomasz 
Published: January 2024

Abstract
Background Hyperandrogenism is among the most common endocrine disorders
in women. Clinically, it manifests as hirsutism, acne, and alopecia. A healthy
lifestyle, including nutritious dietary patterns and physical activity, may
influence the clinical manifestation of the disease. This study determined the
effect of a low-glycemic index anti-inflammatory diet on testosterone levels and
sex hormone-binding globulin (SHBG) and clinical symptoms in hyperandrogenic
women at their reproductive age.
Methods The study included 44 overweight and obese women diagnosed with
hyperandrogenism. The anthropometrics (weight, height, body mass index, waist
circumference, hip circumference), physical activity, and dietary habits were
assessed using valid questionnaires, scales, stadiometer, and tape meter. The
significant p-value was <0.001. Serum testosterone and SHBG levels were
measured using automated immunoassay instruments.
Results The intervention based on a low-glycemic index diet with
anti-inflammatory elements and slight energy deficit decreased total
testosterone levels (p<0.003), increased SHBG levels (p<0.001),
and decreased the free androgen index (FAI; p<0.001). Post-intervention,
overall well-being was much higher than in the pre-intervention period
(p<0.001), and stress was diminished (p<0.001). Western
nutritional patterns positively correlate with clinical hyperandrogenism
progression, whereas several factors of the low-glycemic index diet with
anti-inflammatory elements and slight energy deficit positively associate with
reduced clinical hyperandrogenism symptoms.
Conclusions In overweight and obese women, proper selection of diet,
introduction of moderate physical activity, and reduction in weight, stress
factors, and alcohol consumption translate into several positive effects,
including reduced FAI and symptoms such as acne, hirsutism, menstrual disorders,
and infertility.
Lumen-apposing metal stents for the treatment of pancreatic and peripancreatic fluid collections and bleeding risk: a propensity matched study
Authors: Mangiavillano Benedetto , Lakhtakia Sundeep , Samanta Jayanta , Auriemma Francesco , Vargas-Madrigal Jorge , Arcidiacono Paolo Giorgio , Barbera Carmelo , Ashhab Hazem , Song Tae Jun , Pham Khanh Do-Kong , Teoh Anthony Y.B. , Moon Jong Ho , Crinò Stefano Francesco , Kongkam Pradermchai , Aragona Giovanni , De Lusong Mark A. , Dhar Jahnvi , Ofosu Andrew , Ventra Agostino , Paduano Danilo , Franchellucci Gianluca , Repici Alessandro , Larghi Alberto , Facciorusso Antonio ,   PFC LAMS study group
Published: January 2024

Introduction Endoscopic ultrasound (EUS)-guided drainage of symptomatic pancreatic fluid collections (PFCs) using the Hot-Axios device has recently been associated with a significant risk of bleeding. This adverse event (AE) seems to occur less frequently with the use of a different device, the Spaxus stent. The aim of the current study was to compare the rates of bleeding between the two stents.
Methods Patients admitted for treatment of PFCs by EUS plus lumen-apposing metal stent in 18 endoscopy referral centers between 10 July 2019 and 28 February 2022 were identified and their outcomes compared using a propensity-matching analysis.
Results 363 patients were evaluated. After a 1-to-1 propensity score match, 264 patients were selected (132 per group). The technical and clinical success rates were comparable between the two groups. Significantly more bleeding requiring transfusion and/or intervention occurred in the Hot-Axios group than in the Spaxus group (6.8% vs. 1.5%; P = 0.03); stent type was a significant predictor of bleeding in both univariate and multivariate regression analyses (P = 0.03 and 0.04, respectively). Bleeding necessitating arterial embolization did not however differ significantly between the two groups (3.0% vs. 0%; P = 0.12). In addition, the Hot-Axios was associated with a significantly higher rate of overall AEs compared with the Spaxus stent (9.8% vs. 3.0%; P = 0.04).
Conclusion Our study showed that, in patients with PFCs, bleeding requiring transfusion and/or intervention occurred significantly more frequently with use of the Hot-Axios stent than with the Spaxus stent, although this was not the case for bleeding requiring embolization.
Early Echocardiographic Predictors of Eventual Need for Patent Ductus Arteriosus Treatment: A Retrospective Study
Authors: Koo Jenny , Torres Nohemi , Katheria Anup 
Published: January 2024

Objective Hemodynamically significant patent ductus arteriosus (hsPDA) in preterm neonates is associated with end-organ injury including intraventricular hemorrhage. Early treatment may reduce morbidities but may result in overtreatment. This study aimed to examine the association between commonly obtained echocardiographic markers within the first 12 hours of life and eventual treatment of an hsPDA.
Study Design Patients with <32 weeks' gestational age had blinded echocardiograms done within the first 12 hours of life as part of research protocols. Subsequent treatment of the patent ductus arteriosus (PDA) was determined by the clinical team independent of echocardiogram results. t-tests and chi-square tests were done for continuous data and categorical outcomes. A receiver operating curve was created to optimize cutoff values.
Results Among 199 neonates studied (mean time of echocardiogram 6.7 h after birth), those needing PDA treatment had higher left ventricular output (LVO), right ventricular output (RVO), and superior vena cava (SVC) flow (p-values 0.007, 0.044, and 0.012, respectively). Cutoffs for predicting PDA treatment were LVO > 204 mL/kg/min (63% sensitivity, 66% specificity), RVO > 221 mL/kg/min or SVC flow > 99 mL/kg/min (sensitivities 70 and 43%, specificities 48 and 73%, respectively).
Conclusion Preterm neonates with higher markers of cardiac output in the first 12 hours of birth later required PDA treatment. These data are the first to use standard cardiac output measures in the first 12 hours of life to predict the need for future PDA treatment. Further prospective studies will need to be performed to corroborate these associations between echocardiographic markers and clinical outcomes/morbidities.
Key Points
Rapid Access to cis-1,3-Dialkylindanes: Asymmetric Formal Syntheses of epi-Mutisianthol and epi-Jungianol
Authors: Tran Cong So , Yoon Moonsang , Koh Minseob , Yun Hwayoung , Le Long Duc , Kim Seoyeong , Kim Huiae , Kim Jisu , Nguyen Long Huu 
Published: January 2024

AbstractConcise and strategically unique asymmetric formal syntheses of epi-mutisianthol and epi-jungianol are presented. A novel disconnection approach is introduced to complement previous intramolecular cyclopentannulation strategies. Noteworthy features include: (a) control of the stereogenic benzylic carbon center through 1,3-chirality transfer from chiral indenols via the Johnson–Claisen rearrangement, which yields advanced indene-containing γ,δ-unsaturated esters, and (b) the diastereoselective construction of the cis-1,3-dialkylindane backbone via catalytic hydrogenation of the resulting indene. This approach presents a remarkable method for synthesizing structurally intriguing indane motifs.
Culture as the bad object
Authors: Kerr Nini 
Published: January 2024

AbstractThis paper creatively extends Fairbairn’s theory to investigate the impact of the UK’s hostile environment policy on marginalised communities at the intersection of culture, politics and society. The hostile environment is conceptualised as a disruptive ‘bad object’ in the cultural dimension in alignment with Fairbairn’s theory. Its influence is explored in terms of its unconscious reproduction within the psyche. By juxtaposing context, theory and personal introspection, this paper offers a Fairbairnian exploration of how sociality and sociopolitical contexts interplay with the intricate processes of the human psyche. It provides reflective commentary on how external racial dynamics are internalised within the endopsychic structure, shaping one’s interactions with others, and, more significantly, how one relates to aspects of the self.