bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of potential biomarkers for polycystic ovary syndrome and identification of expression and immune characteristics
Authors: Liu Shuang , Zhao Xuanpeng , Meng Qingyan , Li Baoshan 
Published: October 2023

BackgroundPolycystic ovary syndrome (PCOS) seriously affects the fertility and health of women of childbearing age. We look forward to finding potential biomarkers for PCOS that can aid clinical diagnosis.MethodsWe acquired PCOS and normal granulosa cell (GC) expression profiles from the Gene Expression Omnibus (GEO) database. After data preprocessing, differentially expressed genes (DEGs) were screened by limma package, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and Gene Set Enrichment Analysis (GSEA) were performed. Recursive feature elimination (RFE) algorithm and the least absolute shrinkage and selection operator (LASSO) Cox regression analysis were used to acquire feature genes as potential biomarkers. Time-dependent receiver operator characteristic curve (ROC curve) and Confusion matrix were used to verify the classification performance of biomarkers. Then, the expression characteristics of biomarkers in PCOS and normal cells were analyzed, and the insulin resistance (IR) score of samples was computed by ssGSEA. Immune characterization of biomarkers was evaluated using MCP counter and single sample gene set enrichment analysis (ssGSEA). Finally, the correlation between biomarkers and the scores of each pathway was assessed.ResultsWe acquired 93 DEGs, and the enrichment results indicated that most of DEGs in PCOS group were significantly enriched in immune-related biological pathways. Further screening results indicated that JDP2 and HMOX1 were potential biomarkers. The area under ROC curve (AUC) value and Confusion matrix of the two biomarkers were ideal when separated and combined. In the combination, the training set AUC = 0.929 and the test set AUC = 0.917 indicated good diagnostic performance of the two biomarkers. Both biomarkers were highly expressed in the PCOS group, and both biomarkers, which should be suppressed in the preovulation phase, were elevated in PCOS tissues. The IR score of PCOS group was higher, and the expression of JDP2 and HMOX1 showed a significant positive correlation with IR score. Most immune cell scores and immune infiltration results were significantly higher in PCOS. Comprehensive analysis indicated that the two biomarkers had strong correlation with immune-related pathways.ConclusionWe acquired two potential biomarkers, JDP2 and HMOX1. We found that they were highly expressed in the PCOS and had a strong positive correlation with immune-related pathways.
Concurrent changes in physical activity and physical functioning during retirement transition–a multi-trajectory analysis
Authors: Lintuaho Roosa , Saltychev Mikhail , Pentti Jaana , Vahtera Jussi , Stenholm Sari 
Published: October 2023

Background
Physical activity and physical functioning have been reported to change over retirement transition, but the results have been inconsistent, and the two constructs have not been studied concurrently. The objective of this study was to examine concurrent changes in physical activity and physical functioning during transition to retirement among public sector employees, and to examine if occupation, sex, marital status, body mass index (BMI), alcohol consumption and smoking status are associated with observed different multi-trajectory paths.

Methods
3,550 participants of the Finnish Retirement and Aging study responded to an annual survey on physical activity and physical functioning (SF-36) before and after retirement. Group-based multi-trajectory analysis was used to identify clusters with dissimilar concurrent changes in physical activity and physical functioning. Multinomial regression analysis was used to describe the associations between covariates and the probability of being classified to a certain cluster.

Results
Participants were 63.4 (SD 1.4) years old, 83% women, 65% professional workers. Four trajectories of concurrent changes in physical activity and physical functioning were identified, one with decreasing physical functioning and low activity, one with increasing high activity and stable high functioning and two with fluctuating moderate physical activity and stable high functioning. Single, women, obese participants and risk-users of alcohol were more likely to be classified into group with low physical activity and declining physical functioning.

Conclusions
Low physical activity below the level usually recommended was associated with lower physical functioning during retirement transition. These findings could be useful when planning interventions for retirees to maintain their physical functioning level.
Associations between physical activity, physical fitness, and body composition in adults living in Germany: A cross-sectional study
Authors: Schilling Raphael , Schmidt Steffen C. E. , Fiedler Janis , Woll Alexander 
Published: October 2023

Background & aims
Body composition (BC) changes with age and is associated with morbidity and mortality. A physically active lifestyle influences BC and represents an important predictor of successful aging. To emphasize this, the World Health Organization established activity recommendations for all age groups. We describe BC during adulthood using a cross-sectional sample from a German community and investigate the associations between physical activity (PA), physical fitness (PF), and BC.

Methods
Data from 329 men and women aged 35 to 86 years were analyzed. PA was measured by questionnaire and classified into sport activity and habitual activity. PF was measured through physical performance tests and BC by bioelectrical impedance analysis. Fat mass index (FMI) and fat-free mass index (FFMI) were calculated to represent height-adjusted BC. Associations between PA, PF, and BC were analyzed using linear regression models.

Results
For both sexes, strength was positively associated with FFMI (♂: ß = 0.313; ♀: ß = 0.213) and phase angle (♂: ß = 0.357; ♀: ß = 0.409). For FMI, a significant negative association with strength was found only in women (ß = -0.189). Cardiorespiratory fitness showed a negative association with FMI (ß = -0.312) and FFMI (ß = -0.201) for men, while in women a positive association was found for FFMI (ß = 0.186). For coordination, a significant association with FMI was observed only in women (ß = -0.190). Regarding PA only one significant relationship between sport activity and FMI among women (ß = -0.170) was found.

Conclusions
In our sample, PF was closer related to BC than PA. Strength and cardiorespiratory fitness were the strongest predictors for BC. This supports the World Health Organization’s activity recommendations to include both resistance and endurance training in the weekly sports program to maintain a healthy BC.
Optimizing the Management Algorithm for Esophageal Dysphagia After Index Endoscopy: Cost-Effectiveness and Cost-Minimization Analysis
Authors: Shah Eric D. , Yadlapati Rena , Chan Walter W. 
Published: October 2023

INTRODUCTION:Guidelines advise esophageal motility testing for dysphagia when structural disorders are ruled out, but cost concerns impede adoption. We evaluated cost-effective positioning of esophageal motility testing in the algorithm to evaluate esophageal dysphagia.METHODS:We developed a decision analytic model comparing 3 strategies: (i) esophageal manometry, (ii) screening impedance planimetry followed by esophageal manometry if needed, or (iii) nonalgorithmic usual care. Diagnostic test accuracy was adapted to expected rates of esophageal motility disorders in general gastroenterology populations. We modeled routine testing for all patients with nonstructural/mechanical dysphagia compared with selective testing with strong suspicion for achalasia. Cost outcomes were defined on national commercial and Medicare datasets stratified on age and sex. Health outcomes were modeled on populations with achalasia. The time horizon was 1 year.RESULTS:Motility testing was preferred over nonalgorithmic usual care due to cost savings rather than health gains. To commercial insurers, routine esophageal manometry for nonstructural/mechanical dysphagia would be cost-saving below a reimbursed cost of $2,415. Screening impedance planimetry would be cost saving below a reimbursed cost of $1,130. The limit for reimbursed costs would be lower for patients older than 65 years to achieve cost savings mainly due to insurance. Sex did not significantly influence cost-effectiveness. Patients and insurers preferred routine screening impedance planimetry before manometry when the index of suspicion for achalasia was below 6%.DISCUSSION:Aligning with practice guidelines, routine esophageal motility testing seems cost saving to patients and insurers compared with nonalgorithmic usual care to evaluate nonstructural/mechanical dysphagia. Choice of testing should be guided by index of suspicion.
Editorial
Authors: Papier Joy 
Published: October 2023

It gives me great pleasure to present this brief introduction to our 2023 issue of JOVACET, now in its sixth year of publication and seeking to increase its footprint with each passing year. To illustrate these endeavours, this year saw JOVACET being accepted on two more platforms: the first is the Directory of Open Access Journals (DOAJ), and, more recently, our journal has joined the Scientific Electronic Library Online (SciELO), an open-access searchable database that is managed in South Africa by the Academy of Science of South Africa (ASSAf ), is funded by the South African Department of Science and Technology (DST), and has the endorsement of the South African Department of Higher Education and Training (DHET; see https://www.scielo.org.za for more information about the broader SciELO initiative). As part of the conditions of the SciELO listing, journals are required to publish individual articles on the platform for online access in advance of the completed journal being published. This was a new challenge for JOVACET, as we had not experimented with this requirement previously, and it meant putting some pressure on our time frames for reviewing and editing (so ably managed by Dr Catherine Robertson) so that at least one article could be published as a stand-alone that would also be included in the full journal for this year.
MORE > DOWNLOAD THE FULL EDITORIAL HERE
Penggunaan Tepung Tapioka Sebagai Pengganti Bentonit Pada Lumpur Pemboran Berbahan Dasar Air
Authors: Aji Kusworo Zulfikar , Silviana S , Triadi Putranto Thomas 
Published: October 2023

Fluida pemboran merupakan salah satu aspek yang berperan penting dalam keberhasilan dari operasi pemboran. Lumpur pemboran secara umum berfungsi antara lain sebagai pengangkat serbuk pemboran, menjaga serbuk pemboran tidak jatuh dan menumpuk saat sirkulasi berhenti, menjaga lubang bor dari intrusi fluida formasi, mengurangi friksi dan menjaga lubang bor dari keruntuhan. Sifat-sifat fisik dari lumpur pemboran antara lain adalah densitas, viskositas, gel strength, yield point, dan fluid loss. Bentonit merupakan salah satu material yang lazim dipakai sebagai campuran pada lumpur pemboran, akan tetapi sebagai bahan tambang, tentu saja penambangan bentonit sedikit banyak dapat mempengaruhi kondisi lingkungan yang ada. Tepung tapioka yang mengandung pati, memiliki kemampuan yang relatif sama dengan bentonit ketika diaplikasikan sebagai material campuran lumpur pemboran karena berfungsi sebagai viscosifier dan pencegah fluid loss. Diperlukan suatu analisis untuk mengenai kemampuan tepung tapioka sebagai substitusi bentonit berdasarkan parameter reologi lumpur pemboran. Dari hasil yang didapatkan, jika dibandingkan dengan rekomendasi spesifikasi dari API, lumpur pemboran berbahan dasar tepung tapioka dapat digunakan sebagai substitusi bentonit. Kata kunci: fluida pemboran, lumpur pemboran, densitas, viskositas, gel strength, yield point, fluid loss, bentonit, tepung tapioka, pati AbstractUtilization of Tapioca Starch as a Substitute for Bentonite in Water-Based Drilling Mud. Drilling fluid is one aspect that plays an important role in the success of the drilling operation. Drilling mud has functions as drilling cuttings transporter, keeping cuttings from falling and accumulate when circulation stops, protecting the borehole from formation fluid intrusion, reduce friction and prevents the borehole from collapse. The physical properties of the drilling mud include density, viscosity, gel strength, yield point, and fluid loss. Bentonite is one of the materials commonly used as a mixture in drilling mud, but as a mining material, can more or less affect environmental conditions. Tapioca flour which contains starch has relatively the same ability as bentonite when applied as a drilling mud, functioned as a viscosifier and prevents fluid loss. An analysis is needed to determine the ability of tapioca flour as a substitute for bentonite based on rheological parameters. From the results obtained, if compared to API recommended specification, drilling mud made from tapioca starch can be used as a substitute for bentonite. Keywords: drilling fluid, drilling mud, density, viscosity, gel strength, yield point, fluid loss, bentonite, tapioca flour, starch
Analisis Manajemen Waktu Pada Proyek Pembangunan Jalan Parang Garuda East Kawasan Industri Kendal
Authors: Ayatullah Mumtaz Almukaffa , Syafrudin S , Sarmingsih Anik 
Published: October 2023

Petunjuk ini Proyek konstruksi infrastruktur merupakan rangkaian kegiatan pembangunan yang saling bergantung satu sama lain. Semakin besar suatu proyek infrastuktur, menyebabkan semakin banyak pula masalah yang harus dihadapi mulai dari proses perencanaan sampai dengan pelaksanaan pembangunan. Beberapa permasalahan yang sering dijumpai dalam sebuah proyek infrastuktur diantaranya berupa pengaturan sumber daya seperti tenaga kerja, biaya, waktu, peralatan, dan lain sebagainya. Jika hal tersebut tidak ditangani dengan benar maka akan mengakibatkan keterlambatan penyelesaian proyek, penyimpangan mutu, pembiayaan yang membengkak, pemborosan sumber daya dan lain sebagainya sehingga sangat merugikan saat pelaksanaan proyek tersebut. Oleh karena itu, maka diperlukan seorang insinyur yang mampu menguasai manajemen waktu dan menerapkannya dalam proyek infrastruktur agar dapat meningkatkan efisiensi dan efektivitas pengelolaan proyek sehingga mencapai hasil yang maksimal dari sumber daya yang tersedia. Dengan manajemen waktu yang baik, maka risiko keterlambatan sebuah proyek dapat diminimalisir. Meminimalisir risiko keterlambatan tersebut secara langsung dapat mengurangi risiko pembengkakan biaya proyek serta pada akhirnya akan memberikan keuntungan tersendiri bagi para stakeholder dan tentunya kepada tenant kawasan industri yang menggunakan infrastuktur jalan yang dibangun sehingga bisa segera merasakan manfaatnya setelah proyek tersebut selesai tepat waktu. Kata kunci: proyek infrastruktur, insinyur, manajemen waktu proyek, efektifitas, efisiensi
Quasi-projectivity of images of mixed period maps
Authors: Bakker Benjamin , Brunebarbe Yohan , Tsimerman Jacob 
Published: October 2023

AbstractWe prove a mixed version of a conjecture of Griffiths: that the closure of the image of any admissible mixed period map is quasi-projective, with a natural ample bundle. Specifically, we consider the map from the image of the mixed period map to the image of the period map of the associated graded. On the one hand, we show in a precise manner that the parts of this map parametrizing extension data of non-adjacent-weight pure Hodge structures are quasi-affine. On the other hand, extensions of adjacent-weight pure polarized Hodge structures are parametrized by a compact complex torus (the intermediate Jacobian) equipped with a natural theta bundle which is ample in Griffiths transverse directions. Our proof makes heavy use of o-minimality, and recent work with B. Klingler associating anℝan,exp{\mathbb{R}_{\mathrm{an},\exp}}-definable structure to mixed period domains and admissible mixed period maps.
Rehabilitation of reinforced concrete deep beams by near-surface-mounted steel reinforcement
Authors: Attiya Muhammad Abed , Uraiyer Faris Abaas , Zainul-Abideen Ahmed Yousif Abbas 
Published: October 2023

Abstract
This article describes an experimental investigation of the behavior of reinforced concrete deep beams repaired by near-surface-mounted (NSM) steel bars. The first beam was loaded under a two-point load up to failure, and the other six deep beams were loaded to 0.4 and 0.75 of ultimate load. Then, they were repaired by NSM steel bars. The bar orientation and angle were the main variables in these beams. The primary goal of this study is to determine whether it is possible to restore the reinforced concrete deep beam with shear reinforcement to its full load-carrying capacity by NSM steel bars as the method of repair. All deep beams were tested with a shear span-depth ratio of 0.8. The test findings showed that the NSM steel repair bars were very effective in restoring the loaded deep beams’ full capacity. Moreover, NSM steel bars enhanced the original deep beams’ strength capacity from 4.16 to 19.44%. The ultimate load, mechanisms of failure, load–crack width distribution, and load–deflection profile are tracked as results.
Congruence subgroups and crystallographic quotients of small Coxeter groups
Authors: Kumar Pravin , Naik Tushar Kanta , Singh Mahender 
Published: October 2023

Abstract
Small Coxeter groups are precisely the ones for which the Tits representation is integral, which makes the study of their congruence subgroups relevant. The symmetric group

S
n

{S_{n}}

has three natural extensions, namely the braid group

B
n

{B_{n}}

, the twin group

T
n

{T_{n}}

and the triplet group

L
n

{L_{n}}

. The latter two groups are small Coxeter groups, and play the role of braid groups under the Alexander–Markov correspondence for appropriate knot theories, with their pure subgroups admitting suitable hyperplane arrangements as Eilenberg-MacLane spaces. In this paper, we prove that the congruence subgroup property fails for infinite small Coxeter groups which are not virtually abelian. As an application, we deduce that the congruence subgroup property fails for both

T
n

{T_{n}}

and

L
n

{L_{n}}

when

n
≥
4

{n\geq 4}

. We also determine subquotients of principal congruence subgroups of

T
n

{T_{n}}

, and identify the pure twin group

P
⁢

T
n

{PT_{n}}

and the pure triplet group

P
⁢

L
n

{PL_{n}}

with suitable principal congruence subgroups. Further, we investigate crystallographic quotients of these two families of small Coxeter groups, and prove that

T
n

/
P

⁢

T
n
′

{T_{n}/PT_{n}^{\prime}}

,

T
n

/

T
n
′′

{T_{n}/T_{n}^{\prime\prime}}

and

L
n

/
P

⁢

L
n
′

{L_{n}/PL_{n}^{\prime}}

are crystallographic groups. We also determine crystallographic dimensions of these groups and identify the holonomy representation of

T
n

/

T
n
′′

{T_{n}/T_{n}^{\prime\prime}}

.
Simple 𝔰𝔩
d+1-modules from Witt algebra modules
Authors: Guo Xiangqian , Liu Xuewen , Zhang Fenghua 
Published: October 2023

Abstract
Let

d
≥
1

{d\geq 1}

be an integer and let

𝒲
d

{\mathcal{W}_{d}}

be the Witt algebra.
For any admissible

𝒲
d

{\mathcal{W}_{d}}

-module P and any

𝔤
⁢

𝔩
d

{\mathfrak{gl}_{d}}

-module V,
one can form a

𝒲
d

{\mathcal{W}_{d}}

-module

ℱ
⁢

(
P
,
V
)

{\mathcal{F}(P,V)}

, which as a vector space is

P
⊗
V

{P\otimes V}

.
Since

𝒲
d

{\mathcal{W}_{d}}

has a natural subalgebra isomorphic to

𝔰
⁢

𝔩

d
+
1

{\mathfrak{sl}_{d+1}}

, we can view

ℱ
⁢

(
P
,
V
)

{\mathcal{F}(P,V)}

as
an

𝔰
⁢

𝔩

d
+
1

{\mathfrak{sl}_{d+1}}

-module. Taking

P
=

Ω
⁢

(
𝝀
)

{P=\Omega(\boldsymbol{\lambda})}

, the rank-1

U
⁢

(
𝔥
)

{U(\mathfrak{h})}

-free

𝒲
d

{\mathcal{W}_{d}}

-module, and

V
=

V
⁢

(
𝐚
,
b
)

{V=V({\mathbf{a}},b)}

, the simple cuspidal module over

𝔤
⁢

𝔩
d

{\mathfrak{gl}_{d}}

, we get
the special

𝔰
⁢

𝔩

d
+
1

{\mathfrak{sl}_{d+1}}

-modules

ℱ
⁢

(
𝝀
;
𝐚
,
b
)

=

ℱ
⁢

(

Ω
⁢

(
𝝀
)

,

V
⁢

(
𝐚
,
b
)

)

\mathcal{F}(\boldsymbol{\lambda};{\mathbf{a}},b)=\mathcal{F}(\Omega(%
\boldsymbol{\lambda}),V({\mathbf{a}},b))

which are

U
⁢

(
𝔥
)

{U(\mathfrak{h})}

-free modules of infinite rank.
We determine the necessary and sufficient condition for the

𝔰
⁢

𝔩

d
+
1

{\mathfrak{sl}_{d+1}}

-module

ℱ
⁢

(
𝝀
;
𝐚
,
b
)

{\mathcal{F}(\boldsymbol{\lambda};{\mathbf{a}},b)}

to be simple, and for the non-simple case we construct their proper submodules explicitly.
At last, using the above results, we deduce an explicit simplicity criterion for the generalized Verma modules induced from

V
⁢

(
𝐚
,
b
)

{V({\mathbf{a}},b)}

and obtain a family of simple affine modules from

ℱ
⁢

(
𝝀
;
𝐚
,
b
)

{\mathcal{F}(\boldsymbol{\lambda};{\mathbf{a}},b)}

, which can be viewed as
the non-weight version of loop modules.
The smallest Mealy automaton generating an indicable regular branch group
Authors: Woryna Adam 
Published: October 2023

Abstract
We construct a two-state Mealy automaton A over the three-letter alphabet generating a regular branch group

G
⁢

(
A
)

{G(A)}

, which surjects onto the infinite cyclic group. Some algebraic and geometric properties of the group

G
⁢

(
A
)

{G(A)}

are derived. In particular, this group has a nearly finitary subgroup of index two, is amenable, just non-solvable, has exponential growth, and its action on the corresponding regular rooted tree is self-replicating, contracting, but it does not have the congruence subgroup property. We also derive in detail an ascending finite L-presentation for the group

G
⁢

(
A
)

{G(A)}

.
Comparison of several numerical solvers for a discretized nonlinear diffusion model with source terms
Authors: Neta Beny 
Published: October 2023

Abstract
The numerical solution of the nonlinear system of equations resulting from a real engineering problem is discussed. We use the approximate solution of a system of two nonlinear integrodifferential equations to build the nonlinear system of equations. This system can be solved by Newton’s method if the solution is differentiable, or using some derivative-free methods, such as Steffensen’s method. Here we show that Steffensen’s method does not always converge and secant method requires more iterations than Traub’s method and Newton’s method. We recommend Traub’s method in case the solution is not differentiable.
On the uniqueness theorems for transmission problems related to models of elasticity, diffusion and electrocardiography
Authors: Shlapunov Alexander , Shefer Yulia 
Published: October 2023

Abstract
We consider a generalization of the inverse problem of the electrocardiography in the framework of the theory of elliptic and parabolic differential operators.
More precisely, starting with the standard bidomain mathematical model related to the problem of
the reconstruction of the transmembrane potential in the myocardium from known
body surface potentials, we formulate a more general transmission problem for elliptic and
parabolic equations in the Sobolev type spaces and describe conditions, providing
uniqueness theorems for its solutions. Next, the new transmission
problem is interpreted in the framework of the elasticity theory applied to composite
media. Finally, we prove a uniqueness theorem for an evolutionary
transmission problem that can be easily adopted to many models involving the diffusion type equations.