bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease.
Authors: Ito Yuhei , Ichikawa Yasutaka , Murashima Shuichi , Sakuma Hajime , Nakajima Ayako 
Published: February 2024

Abstract

Objectives: Rheumatoid arthritis (RA) related interstitial lung disease (ILD) impacts on the treatment strategy and its prognosis in patients with RA. However, the relationship between RA disease activity and the severity of comorbid ILD has not been fully investigated. This study aimed to investigate the impact of RA disease activity on the severity of comorbid ILD in detail based on currently established visual scoring method along with physiological severity.
Methods: Consecutive patients with RA visiting to our Rheumatology Centre between December 2020 and December 2023 were analysed. The radiological severity of ILD was evaluated by averaging the extent of the combined lesion of ground glass opacity, reticulation and honeycombing in 5% increments in six representative high-resolution computed tomography slices ranging from 0% (no involvement) to 100% (all lung fields affected) according to Goh and Walsh’s method. Associations between the radiological and physiological severity of ILD and patients’ features were investigated using linear regression analysis.
Results: Among 124 patients (32 men, 92 women), the median age was 70 years, and the median disease duration was 2.92 years. Radiological severity of ILD was 0% (without ILD) in 107 (86.2%), ILD with extent <10% in nine (7.2%), ILD with extent ³10% and <20% in three (2.4%), ILD with extent ³20% in five (4.0%). Both disease activity score (DAS)28-erythrocyte sedimentation rate (ESR) (standardized coefficient = 0.199, P = 0.03) and rheumatoid factor titre (standardized coefficient = 0.247, P = 0.01) were significantly associated with the radiological quantitative severity of ILD in multivariate analysis adjusted for age, sex, disease duration, smoking status and anti-citrullinated peptide antibody titre. DAS28-ESR was significantly associated with forced vital capacity% predicted (standardized coefficient = -0.230, P = 0.047).
Conclusion: Disease activity of RA was significantly associated with the severity of RA-ILD both radiologically and physiologically.
Does Enterprise Digital Transformation Reduce Tax Compliance?
Authors: ren gaofei 
Published: February 2024

Abstract
In the era of the digital economy characterized by technologies such as artificial intelligence, big data, and cloud computing, digital transformation has become a key path for enterprises to enhance their competitiveness and achieve sustained growth. Existing research has not reached a consensus on the impact of corporate digital transformation on tax compliance behavior, and there is a lack of empirical evidence from a micro perspective on the level of an enterprise. This study explores the impact of enterprises' digital transformation on tax compliance behavior based on data from 2011–2022 Chinese listed companies. Results show that the digital transformation of enterprises can significantly reduce tax compliance behavior by reducing tax avoidance costs. Further research found that this negative effect has significant heterogeneity among enterprises of different ownership and size. Our findings not only expand the theoretical understanding of enterprise digital transformation and tax compliance but also provide theoretical support for governments to promote enterprise digital transformation and tax supervision.
Preferential Graphitic-Nitrogen Formation in Pyridine-Extended graphene Nanoribbons
Authors: Ruffieux Pascal , Bassi Nicolo , Xiushang Xu , Xiang Feifei , Krane Nils , Pignedoli Carlo Antonio , Narita Akimitsu , Fasel Roman 
Published: February 2024

Abstract

Graphene nanoribbons (GNRs), nanometer-wide strips of graphene, have garnered significant attention due to their tunable electronic and magnetic properties arising from quantum confinement. A promising approach to manipulate their electronic characteristics involves substituting carbon with heteroatoms, such as nitrogen, with different effects predicted depending on their position. In this study, we present the extension of the edges of 7-atom-wide armchair graphene nanoribbons (7-AGNRs) with pyridine rings, achieved on a Au(111) surface via on-surface synthesis. High-resolution structural characterization confirms the targeted structure, showcasing the predominant formation of carbon-nitrogen (C-N) bonds (over 90% of the units) during growth. This favored bond formation pathway is elucidated and confirmed through density functional theory (DFT) simulations. Furthermore, an analysis of the electronic properties reveals a reduction of the band gap of the GNR, accompanied by the presence of nitrogen-localized states. Our results underscore the successful formation of C-N bonds on the metal surface, providing insights for designing new GNRs that incorporate substitutional nitrogen atoms to precisely control their electronic properties.
Acquired deforming hypertonia in French Caribbean people: a cross-sectional analysis in long-term care units
Authors: KERJEAN Nicolas , BANYDEEN Rishika , GLIZE Bertrand , BONNET Michel , RENE-CORAIL Patrick , TABUE Maturin , DRAME Moustapha , DEHAIL Patrick , BARNAY José-Luis 
Published: February 2024

Abstract
Background: Osteoarticular deformities or contractures in institutionalized elderly individuals, described as acquired deforming hypertonia (ADH), have a multifactorial origin. The reported prevalence of ADH in French Caucasian patients in long-term care units (LTCUs) is 25.6%. To date, ADH in the Caribbean population has never been studied. We aimed to assess the prevalence and characteristics of ADH in such a population.
Methods: This was a cross-sectional observational study of a French Caribbean population in Martinique in which patients aged 75 years or older were institutionalized in LTCUs during the study period. Data extraction from the medical files of eligible LTCU patients was conducted to assess the prevalence, clinical characteristics and impact of ADH on patients’ daily care. The assessments were performed collaboratively between the patients’ geriatric team and a PM&R physician.
Results: In total, 81 patients were included, with an ADH prevalence of 77.8%. Reported ADH was bilateral (86%) or multiple (66% of patients had ≥ 5 ADH) and was responsible for major alterations in terms of hygiene, dressing, pain, and skin damage. ADH patients had a high level of dependence (GMP=924), and this level of dependence was significantly associated with the presence of at least one ADH (p<0.001) regardless of prior disease.
Conclusions: The incidence of ADH in our Caribbean population seems twice as high as that in Caucasian patients, underlining the necessity for this nosological framework to be better recognized, particularly in an insular context. Local campaigns for the prevention and recognition of ADH must be considered, and targeted multidisciplinary protocols need to be established for adapted care in all institutions receiving elderly people.
Insulin-like growth factor binding protein-3 (igfbp-3) and igfbp-5 in yellowtail kingfish (Seriola aureovittata): Molecular identification and expression under different nutritional status and stocking density
Authors: Zheng Jichang , Zhang Wenjing , Xu Yongjiang , Cui Aijun , Jiang Yan , Wang Bin 
Published: February 2024

Abstract
Insulin-like growth factor-binding proteins (IGFBPs) play an important role in regulating growth and development by binding to IGF, with IGFBP-3 and IGFBP-5 being the main binding carriers of IGF in circulation system. In the present study, the gene sequences of igfbp-3, igfbp-5a and igfbp-5b were cloned from the liver of yellowtail kingfish (Seriola aureovittata). The ORF sequences of igfbp-3, igfbp-5a and igfbp-5b were 888, 801 and 804 bp in length, which encoded 295, 266 and 267 amino acids, respectively. The above three genes were widely expressed in detected yellowtail kingfish tissues, with igfbp-3 being the most highly expressed in the heart, brain and gonads, while igfbp-5a and igfbp-5b were both most highly expressed in the liver and kidney. The gene expression of igfbp-3, igfbp-5a and igfbp-5b was detected throughout the embryonic and larval stages, suggesting their roles in early development and growth regulation of yellowtail kingfish. Besides, igfbp-3 and igfbp-5a were significantly up-regulated in liver under food deprivation and high-density rearing conditions, which was exactly opposite to the growth performance of yellowtail kingfish, identifying their typical growth inhibitory profile and implying that they may serve as biomarkers of adverse culture conditions. Overall, the above results initially identified the molecular characteristics of igfbp-3 and igfbp-5 in yellowtail kingfish and demonstrated that they play important roles in the growth and development, providing a basis for further research on underlying regulatory mechanisms.
A BLE-based communication network architecture for smart mobile devices to prevent rapid battery drain
Authors: Çetingöz Mustafa , Taşkın Deniz 
Published: February 2024

Abstract
Internet usage and user interaction on mobile smart devices have grown exponentially with technological advancements, leading to a major challenge: rapid battery depletion. This study addresses this issue by proposing a novel communication network designed to reduce power consumption on smart mobile devices during internet communication. The proposed architecture leverages Bluetooth Low Energy (BLE) technology, known for its energy efficiency. The system comprises two main components: a hardware unit that manages internet tasks via Wi-Fi and transmits notifications to the mobile device using BLE, and a new dedicated smartphone application that receives these notifications and alerts the user. To evaluate the system's effectiveness, a custom measurement system was developed. This system assessed the power consumption of the smartphone in standby mode, measured the power consumption of an email application selected for testing purposes while different connectivity options (3G, LTE and Wi-Fi) were active, and finally assessed the power consumption of the new mobile application using the developed communication methods. The findings demonstrate that the proposed architecture offers significant advantages in scenarios requiring frequent communication.
Radiographic Parameters and feasibility analysis of dual sacral-2 alar-iliac screw fixation using three-dimensional digital technology
Authors: Xie Mengqi , Chen Chao , Sun Xun , Dong Xiaoman , Wang Zhi , Zhao Dong , Liu Gang , Zhu Shan , Xu Baoshan , Zhao Yu , Ma Xinlong , Yang Qiang 
Published: February 2024

Abstract
Objective
The purpose of this study was to evaluate the feasibility and the trajectories of dual sacral-2 alar-iliac (S2AI) screw fixation with three-dimensional digital technology simulation analysis.
Methods
The pelvic computed tomography scan data of 60 (30 men and 30 women, age: 25–86 years) individuals were selected and reconstructed. The trajectories of dual S2AI screws were plotted using three-dimensional reconstruction software. A cylinder with a radius of 5 mm was selected to simulate screw placement. If screw placement based on the cylinder with 5 mm radius failed, selected a cylinder with a radius of 4.5 mm or 4 mm. Dual S2AI trajectories were simulated, the maximum length and width of the trajectories were ensured, and their parameters were precisely measured. All parameters were measured in the three-dimensional image, including distance parameters, radius and angles.
Results
The placement of dual S2AI screws on the same side could be achieved in all individuals. No significant differences were found between the male and female regarding the head inclination angle, abduction angle, and total length or thread length of screws in the same position (P > 0.05). LH(the shortest distance from the greater sciatic notch to the cross-section of the screw trajectory)were17.52 ± 3.96 mm and 14.18 ± 2.92 mm in L1,28.19 ± 2.58 mm and 25.54 ± 4.15 mm in L2, 16.09 ± 4.08 mm and 14.71 ± 3.94 mm in R1, 26.90 ± 3.76 mm and 24.59 ± 2.85 mm in R2 in male and female models, respectively. The shortest distance from the greater sciatic notch to the cross-section of the screw trajectory differed significantly between the sexes (P < 0.05).
Conclusion
Using a radius of 4 mm (minimum diameter of S2AI screw) as a standard, it is feasible to place two S2AI screws on the same side for the Chinese adult. Screw placement can be achieved by trisecting the lateral process of S1-S2, with one screw inserted in the bottom third and the other in the upper third. Furthermore, preoperative three-dimensional digital technology simulation analysis can effectively simulate the dual S2AI screws trajectories on the same side, and they can provide accurate data for clinical applications.
Electric Field Measurements at Aragats Observatory: How to Make the Physical Inferences From the Multivariate Correlated Information
Authors: Chilingarian Ashot , Karapetyan T. , Sargsyan B. , Khanikyanc Y. , Chilingaryan S. 
Published: February 2024

Abstract
To make transformational scientific progress in Space science and geophysics, the Sun, heliosphere, magnetosphere, and different layers of the atmosphere must be studied as a coupled system. The presented paper describes how information on complicated physical processes in the atmosphere can be immediately assessable for researchers via an advanced multivariate visualization system with a simple statistical analysis package. Research of the high-energy phenomena in the atmosphere and the atmospheric discharges is of special importance. The relationship between thundercloud electrification, lightning activity, wideband radio emission, and particle fluxes has not yet been established. One of the most intriguing opportunities opened by observation of the high-energy processes in the atmosphere is their relation to lightning initiation. Investigations of the accelerated structures in the geospace plasmas can also shed light on particle acceleration up to much higher energies in the similar structures of space plasmas in the distant objects of the Universe. For example, we demonstrate how to infer the physical inferences from time series of the surges of particle flux intensity, near-surface electric field strength, records of wideband field, and interferometer antenna signals.
Risk Management of Venous Thromboembolism in Inpatients at Tertiary Hospitals in China: A Retrospective Longitudinal Study
Authors: Shi Ziyue , Yu Yaqian , Hou Yifang , Duan Jun , Hu Yonghuan , Huang Chengzhang , Jiang Enshe , Deng Xiaomei 
Published: February 2024

Abstract
Background
While it is recognized that racial differences in the risk of venous thromboembolism (VTE) exist between Asian and Western populations, comprehensive data on VTE risk, bleeding risk, and prevention strategies among large-scale hospitalized patients in China remain limited.
Materials and Methods
A retrospective longitudinal study was conducted on 85,366 adult inpatients, hospitalized for more than 24 hours at a tertiary comprehensive hospital in China from May 1, 2021 to April 30, 2022. Standardized assessment tools recommended by the 9th edition of the CHEST guidelines were used to assess the patient’s VTE and bleeding risks. An analysis was performed on their demographic characteristics, risk factors, use of prevention measures, and VTE incidence.
Results
The study found that among surgical and medical inpatients, the proportions of patients at high risk for VTE were 4.97% (95%CI: 4.77%-5.18%) and 11.23% (95%CI: 10.93%-11.53%), respectively. The highest proportions of high-risk patients were observed in diseases of the circulatory system (9.90%, 95%CI: 8.83%-11.08%) and certain infectious and parasitic diseases (19.31%, 95%CI: 16.36%-22.64%). Among those assessed for bleeding risk, the proportions of surgical and medical inpatients at high risk were 3.47% and 16.69% (95 CI: 15.57%-17.87%), respectively. However, the proportion of patients receiving different types of preventive measures did not reach 80% in both surgical and medical groups. The VTE incidence rates during hospitalization for surgical and medical patients were 0.65% (95%CI:0.58%-0.73%) and 2.24% (95 CI: 2.1%-2.39%), respectively, with the highest VTE rates observed in patients with diseases of the circulatory system both. The study also found significant differences in VTE risk among different diseases and between surgical and medical inpatients.
Conclusion
Despite most patients undergoing VTE and bleeding risk assessments, adherence to guideline-recommended prevention strategies was not optimal. This underscores the need for healthcare professionals to raise awareness and take proactive measures to reduce the disease burden and improve patient outcomes.
The effect of Center-Perforated tapered twisted tape insert in tube on the performance of heat exchanger: A numerical approach
Authors: Yadav Ajeet , Gupta Rajesh , Mohit Manish Kumar 
Published: February 2024

Abstract
Inserts of twisted tapes in tubes with a large number of variations have long been used to enhance heat transfer rate and improve heat exchanger performance. Although, this improved the heat transfer rate but tends to increase the friction factor simultaneously. This paper primarily focuses on the investigation of inserts of twisted tapes with varying widths instead of constant ones to improve thermos-hydraulic performance with an adequate reduction in friction factor. Further perforated twisted tape insert is expected to provide a reduction in the wetted area of the tube and reduce pressure drop. A numerical investigation using the ANSYS FLUENT is carried out to analyze the performance of the center-perforated tapered twisted tape with water as working fluid under laminar flow conditions i.e. 500 ≤ Re ≤ 1750. In addition to this, twin tapered TT configuration is also analyzed; a total of 36 cases are evaluated. The computational results revealed that the flow resistance is reduced with the proposed twisted tape configuration as compared to the plain twisted tape; however, thermal performance is affected only marginally. In the optimization study, it is advised to use the tapered twisted tape arrangement because it results in a significant reduction of pressure drop, about 65 percent, as well as the power input for the marginal reduction in thermal performance.
Third(fourth) order accurate method for one dimensional local fractional Viscous Burgers’ and diffusion-convection equations
Authors: Pandey Ankit , Mohanty R. K. 
Published: February 2024

Abstract
A Singular fractal boundary value problem whose order term is a Hausdroff Fractal derivative of order δ ∈ (0, 1] is considered. In this article, using three grid points, we discuss the variable mesh method of order three that requires only three function evaluations on some regularity conditions. we give importance to solve a singular problem in our scheme and prove that the recommended scheme is significant. We also discussed the convergence analysis of our method and proved that the method is reliable, like classical numerical methods. Special numerical illustrations for solving linear and nonlinear fractal differential equations are provided to demonstrate the accurate outcome of the recommended method, which has been discussed in convergence analysis.
Pulmonary function, genetic predisposition, and the risk of cirrhosis: A prospective cohort study
Authors: Guo Rongchang , Wang Lanbo , Liu Tiancong , Li Shiwen , Liu Yashu , Yang Honghao , Chen Liangkai , Ji Chao , Xia Yang 
Published: February 2024

Abstract

Background
Pulmonary function is known to be associated with the development of chronic liver disease. However, evidence of the association between pulmonary function and cirrhosis risk is still lacking. This study aimed to investigate the longitudinal associations of pulmonary function with the development of cirrhosis, and to explore whether genetic predisposition to cirrhosis modifies these associations.
Methods
A total of 308,678 participants free of cirrhosis and had undergone spirometry at baseline from the UK Biobank were included. Cirrhosis diagnoses were ascertained through linked hospital records and death registries. Cox proportional hazard models were employed to investigate the longitudinal associations between pulmonary function, genetic predisposition, and cirrhosis risk.
Results
During a median follow-up of 12.0 years, 2,725 incident cirrhosis cases were documented. Compared to individuals with normal spirometry findings, those with preserved ratio impaired spirometry (PRISm) findings (hazard ratio [HR] and 95% confidence interval [CI]: 1.30 [1.16, 1.45]) and airflow obstruction (HR [95%CI]: 1.19 [1.08, 1.32]) had a higher risk of developing cirrhosis after adjustments. These associations were consistent across all categories of genetic predisposition, with no observed modifying effect of genetic predisposition. In joint exposure analyses, the highest risk was observed in individuals with both a high genetic predisposition for cirrhosis and PRISm findings (HR [95% CI]: 1.68 [1.41, 2.00]).
Conclusion
Our findings indicate that worse pulmonary function is a significant risk factor of cirrhosis, irrespective of genetic predisposition.
The prognosis and immune repertoire characteristics of HBsAg and anti-HBs double positivity chronic hepatitis B patients
Authors: Liang Huijun , Wang Haifang , Liang Minfeng , Zhang Xiaobin , Dai Meifen , Li Haixia , Li Xin , Yin Xiaofeng , Liu Xinyao , Guan Ziyun , Qiu Yurong 
Published: February 2024

Abstract
Background: Coexistence of HBsAg and anti-HBs has been observed in some chronic hepatitis B patients, but the clinical outcomes and comprehensive characterization of immune microenvironmental changes for this specific population remain inconclusive.
Methods: A retrospective analysis of 305 patients in Foshan City, Guangdong Province, China, was conducted to investigate the prognosis. Molecular immunology changes of HBsAg and anti-HBs dual-positive chronic HBV patients (DP) and recovery patients (RP) were detected using TCR and BCR immune repertoire sequencing technology.
Results: Our findings revealed that 22.30% of the dual-positive patients in Foshan district, Guangdong province, were diagnosed with severe liver disease. Furthermore, immune repertoire sequencing demonstrated significant skewing in the diversities of TRB and BCR in the DP group compared to the RP group. V(D)J combinations, such as IGHV1-18/IGHD3-22/IGHJ5, IGHV1-8/IGHD6-13/IGHJ3, and IGHV1-8/IGHD6-19/IGHJ3, along with TRBV12-3/TRBD1/TRBJ1-5 and TRBV11-2/TRBD2/TRBJ2-1, emerged as potential biomarkers for diagnosing the DP group. Additionally, distinct amino acid motifs in the TCR CDR3 of DP and HC groups, compared to the RP group, were identified. Notably, motifs "xxxYDSSGYx" and "AREx" in the BCR were selectively prevalent in the DP group, suggesting their potential to specifically identify the DP group from the RP group.
Conclusions:These findings provide evidence for the poor clinical prognosis of dual-positive chronic HBV patients, offer new insights for the study of immune microenvironmental changes and pathogenesis, and may contribute to the development of potential diagnostic biomarkers and therapeutic targets for the DP group.