bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 impact on liver attenuation by computed tomography: a retrospective cohort study
Authors: Gonchar A. P. , Shumskaya Yu. F. , Mnatsakanyan M. G. , Blokhin I. A. , Zakharova D. K. , Reshetnikov R. V. , Gombolevskiy V. A. , Vasilev Yu. A. 
Published: October 2023

Introduction. A high prevalence of decreased liver attenuation has been shown in patients with COVID-19, but there is no unequivocal estimate of the effect of disease severity on it. There has been no evaluation of the liver status both before and after COVID-19.Aim: To study the impact of COVID-19 on liver attenuation by two computed tomography (CT) scans: before and after the onset of pneumonia.Material and Methods. Retrospective cohort study was performed. Data of COVID-19 outpatients were analyzed. Inclusion criteria: two chest CT scans, alanine aminotransferase (ALT), aspartate aminotransferase (AST) blood values, polymerase chain reaction to verify SARS-CoV-2. A PCR positive result was a criterion for the COVID-19 presence. The criteria for absence were a negative PCR result on an oropharyngeal swab for SARS-CoV-2, and absence of a lung lesion on both CT scans. The endpoint was a decrease in liver density of more than 10 HU. Two comparison groups have been identified following the achievement of the endpoint. Liver attemuation was analyzed by automatic segmentation, with values less than 40 HU being considered pathologic.Results. Data from 499 patients were selected and two comparison groups were formed: group 1 – liver attenuation decreased by more than 10 HU in the dynamics and group 2 – control group. Liver attenuation on baseline CT was 8.4 HU higher (95% confidence interval (CI) 5.5-11.2; p-value < 0.001) in group 1 versus group 2. Regression analysis showed an association between a decrease in liver attenuation 10 HU or more on follow-up and low liver attenuation on primary CT (odds ratio 0.26 (95% CI 0.1-0.69), p-value = 0.002). Other factors had no significant effect on the liver attenuation change.Conclusion. COVID-19 has no effect on liver attenuation, which may indicate that there is no significant effect of the virus on liver status.
Comparative assessment of echocardiographic parameters in persons without diagnosed chronic non-communicable diseases depending on body mass index
Authors: Rogozhkina E. A. , Dzhioeva O. N. , Angarsky R. K. , Ivanova A. A. , Maximova O. A. , Drapkina O. M. 
Published: October 2023

Aim: To compare the indicators of structural remodeling and intracardiac hemodynamics in people without previously diagnosed chronic non-communicable diseases, depending on body mass index (BMI).Material and Methods. We analyzed the data of 123 people aged 21 to 59 years who did not have chronic non-infectious diseases and did not take any drug therapy that affects the indicators of central and peripheral hemodynamics, as well as lipid, carbohydrate and fat metabolism. All the examined persons were divided depending on the BMI into 2 groups, comparable in sex, but with age differences. The first group consisted of 60 people (75% women) with a BMI < 30 kg/m2, whose median age was 40 years (Q1–Q3: 35–48 years). The second group included 63 subjects (76.1% women) with BMI ≥ 30 kg/m2 at the age of 48.5 years (Q1–Q3: 38–54 years). Structural and functional parameters of the heart were assessed during transthoracic echocardiography, which was performed on the Philips EPIQ CVx 2D ultrasound machine by one specialist.Results. In the group of persons with increased BMI, the average values of the left ventricular relative wall thickness (RWT LV) were higher – 0.37 [0.34; 0.40] versus 0.41 [0.37; 0.47], p = 0.01; left ventricular mass index (LVMI) – 64.0 [53.0; 76.5] g/m2 and 27.0 [23.1; 30.9] g/m2,7 vs. 82.0 [70.0; 92.0] g/m2 and 38.1 [34.5; 46.5] g/m2,7, p = 0.01; epicardial fat (EF) – 5 [4; 6] mm vs. 8 [5; 10] mm, p = 0.01, left ventricular global longitudinal strain (LV GLS) –21.8 [–23.6…–19.7]% vs. –19.2 [–21.2…–18.2] %, p = 0.01. Statistically direct correlations of BMI with LVMI g/m2,7 (ρ = 0.746; p = 0.01), EF (ρ = 0.563; p = 0.01), LV GLS (ρ = 0.418; p = 0 .01), RWT (ρ = 0.438; p = 0.01). With an increase in BMI by 1 kg/m2, one should expect an increase in the thickness of EF by 0.172 mm, longitudinal deformation of the LV by 0.151%, RWT by 0.003, LVMI, g/m2 by 1.200, LVMI g/m2,7 by 1.116.Conclusion. The increase in BMI is associated with changes in structural remodeling and systolic function of the LV. In individuals with increased BMI, to determine structural remodeling and changes in the geometry of the heart chambers, it is necessary to use growth indexing, to determine indicators of GLS LV, to determine the thickness of EF in order to detect intracardiac hemodynamic disorders in the early stages and timely prevention of complications.
Transit-time flowmetry measurement features of coronary bypass grafts after multiple percutaneous coronary interventions
Authors: Zatolokin V. V. , Alisherov Y. U. , Vechersky Y. Y. , Panfilov D. S. , Kozlov B. N. 
Published: October 2023

The functionality of coronary bypass grafts after surgical myocardial revascularization in patients with coronary heart disease directly depends on the state of the target coronary arteries. In the presence of widespread and diff use atherosclerotic lesions or microcirculatory dysfunctions, a high frequency of coronary bypass dysfunctions is noted in the near future. In some cases, shunt dysfunction can lead to severe hemodynamic instability, accompanied by acute circulatory disorders.Aim: To assess the function of coronary bypass grafts during myocardial revascularization using the method of ultrasonic flowmetry in patients with and without a history of multiple percutaneous coronary interventions (PCI).Material and methods. The retrospective study included 47 patients who underwent coronary artery bypass surgery. A total of 145 coronary bypass grafts were performed. All patients were divided into 2 groups. Group 1 (PCI group) included patients after multiple previous PCI (n = 25; 74 coronary bypass grafts), group 2 (without PCI) included patients without previous PCI (n = 22; 71 coronary bypass grafts). All patients underwent intraoperative ultrasonic flowmetry of coronary bypass grafts using the VeriQ system (Medistim, Norway).Results. When analyzing the status of coronary bypass grafts in patients after multiple PCI, a significantly low mean volumetric blood flow rate was noted (29.5 ± 8.3 ml/min and 48.2 ± 11.6 ml/min, respectively, p = 0.0001) and lower diastolic filling (55.2 ± 8.2% and 71.9 ± 7.1%, p = 0.0001). Also in the group of patients after multiple PCI, there were 2 (2.7%) cases of revision of the distal anastomosis due to a high pulsatile index and low volumetric blood flow velocity. However, no such events were noted in the group without PCI.Conclusions. Previous percutaneous coronary interventions are compromising factors for the state of the coronary bed, which reduces the functional status of coronary bypass grafts and may increase the perioperative risk of surgical myocardial revascularization.
Effect of renal denervation on diastolic function in patients with resistant hypertension and type 2 diabetes mellitus
Authors: Manukyan M. A. , Falkovskaya A. Yu. , Pekarskiy S. E. , Zyubanova I. V. , Solonskaya E. I. , Ryabova T. R. , Vtorushina A. A. , Khunkhinova S. A. , Skomkina I. A. , Yevtukh A. A. , Mordovin V. F. 
Published: October 2023

Aim: To assess the change in the left ventricular (LV) diastolic function (DF) in patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM) during 6-month follow-up after renal denervation (RDN) according to echocardiography in conjunction with changes in hemodynamic parameters.Material and Methods. A single center prospective interventional study with renal denervation included 30 patients with RHTN and T2DM. All patients underwent measurement of office and 24-hour blood pressure (BP), echocardiography according to the standard method with an assessment of LV DF.Results. At 6 months after RDN, a significant antihypertensive effect was noted (p < 0.05), as well as an improvement in LV DF in the form of a decrease in E/e` by 1 c.u. was observed in 50% (15) patients. A significant decrease in the average E/e` was documented (–1.3 [95% CI –2.55; –0.08], р = 0.038). There were no changes in the indexed volumes of the left atrium (р = 0.940). The baseline values of E/e` had correlation with the level of mean pulse BP 24h (r = 0.51, р = 0.001) in the absence of significant relationships with other ABPM parameters. A decrease in systolic BP 24h by 3 mm Hg and an increase in nocturnal systolic BP fall by 1.6% were accompanied by a decrease in the average E/e` by 1 unit. According to the ROC-analysis, baseline level of nocturnal systolic BP fall 5.5% or less associated with a decrease in the E/e` ratio by more than 1 unit.Conclusion. Renal denervation in patients with RHTN and T2DM is accompanied by a favorable effect on LV diastolic function during 6-month follow-up, closely related to the hemodynamic effects of the procedure such as a decrease in systolic and pulse BP 24h, as well as improvement in the circadian rhythm of BP.
The study the effectiveness of the combined enterosorbent based on calcium hydroxyapatite in eimeriosis treatment
Authors: Zlobina O. V. , Bugaeva I. O. , Glukhova I. V. , Larionov S. V. , Korotova D. M. , Glukhova A. V. , Pichkhidze S. Ya. 
Published: October 2023

Introduction. Protozoal intestinal infections are quite common in the modern world. They cause severe clinical manifestations, and in some cases, more often, in countries with a hot climate, lead to death. This is due to the ability of the pathogen to enter the human body through water, fecal-oral or alimentary routes. In this regard, the development of a new safe and effective enterosorbent for protozoal diseases affecting the gastrointestinal tract is relevant.Aim: To study the effectiveness of the combined enterosorbent based on hydroxyapatite and compare the effectiveness of its use with colloidal silicon dioxide (Polysorb) in relation to protozoa (eimeria) in an experiment on rabbits.Material and Methods. The development of a combined enterosorbent based on calcium hydroxyapatite and experimental treatment of laboratory animals (rabbits - 40 animals) infected with protozoal disease - eimeriosis was carried out. Four groups were formed: healthy control, infected control, infected experimental group, infected comparison group (comparison drug – Polysorb). The therapy was carried out for 5 days. The drugs were administered orally.Results. It is shown that the use of a combined enterosorbent based on calcium hydroxyapatite in a daily dose of 0.05 g per 1 kg of body weight led to a decrease in the intensity of invasion of the gastrointestinal tract of rabbits by oocysts by 80% compared with the control, and the use of colloidal silicon dioxide in a daily dose of 0.1-0.2 g per 1 kg of body weight by 49% compared with control.Conclusion. The combined preparation based on calcium hydroxyapatite effectively reduces the intensity of invasion by oocysts of the gastrointestinal tract of rabbits in the experiment. Its intensity efficiency exceeds the intensity of colloidal silicon dioxide by 31%.
Telemedicine technologies in patients undergoing percutaneous coronary interventions for acute myocardial infarction: a review of current trends
Authors: Dyakova A. O. , Bessonov I. S. 
Published: October 2023

Cardiology is one of the fields in which telemedicine technologies were first developed and introduced into everyday clinical practice. One of the main advantages of telemedicine is the possibility of remote monitoring of patients for the purpose of secondary prevention of cardiovascular diseases. This review presents the current trends of telemedicine technologies in the observation of patients undergoing percutaneous coronary interventions for acute myocardial infarction, an analysis of current clinical studies on this issue.Key points: 1. The article shows the important role of telemedicine technologies in working with cardiological patients.2. The use of telemedicine consultations improves survival, quality of life, functional status and reduces the profile of cardiovascular risk, as well as reduces repeated hospitalizations and mental disorders.3. The review of scientific research sets up to review the current clinical recommendations of scientific communities on the management of patients with cardiovascular diseases and raises the question of the need for widespread introduction of telemedicine technologies.
Possibilities of combined PET/CT with 18F-FDG in evaluating the effectiveness of targeted therapy in patients with non-small cell lung cancer
Authors: Strutynsky V. A. , Sinitsyn V. E. , Roytberg G. E. , Platonova O. E. 
Published: October 2023

Introduction. Early assessment of the effect of targeted therapy in patients with non-small cell lung cancer (NSCLC) and a mutation in the EGFR gene is important for the timely correction of antitumor therapy.Aim: To study the possibilities of combined positron emission and computed tomography with 18F-fluorodeoxyglucose (PET/ CT with 18F-FDG) using the RECIST 1.1 and PERCIST 1.0 criteria. In a comparative assessment of the effect of various targeted therapy options in patients with NSCLC and a mutation in the EGFR gene.Material and Methods. The study included 86 patients with stage II-IV NSCLC, including 56 patients with a mutation in the EGFR gene. Of these, 32 patients received targeted monotherapy with tyrosine kinase inhibitors (TKI) – gefitinib or erlotinib and 24 patients received combination therapy (TKI + bevacizumab). The control group consisted of 30 patients who received platinum-containing chemotherapy drugs in combination with bevacizumab. The effect of antitumor therapy was evaluated using the combined PET method/CT with 18F-FDG using RECIST 1.1 and PERCIST 1.0 criteria. The results of the study were compared before the start of treatment and after 4-6 weeks of treatment.Results. In the repeated study of PET/CT with 18F-FDG, a partial positive response to the treatment of both tumor foci and affected regional lymph nodes according to the metabolic criteria PERCIST 1.0. was observed 1.3–1.8 times more often than when using the anatomical criteria RECIST 1.1. (p = 0,049). The frequency of а positive response to treatment in patients receiving targeted monotherapy was quite comparable to that in patients in the control group (43.7 and 40.0%, respectively). Based on 18F-FDG repeat PET/CT and PERCIST 1.0 metabolic criteria in patients receiving combined targeted therapy, a partial positive effect of treatment (58.3%) was observed 1.4 times more often, and disease progression was 4 times less common than in the subgroup of targeted monotherapy and in the control group (p = 0,043).Conclusions. Possibilities of early assessment of the effect of antitumor therapy using PET/CT with 18F-FDG increase when using the metabolic criteria PERCIST 1.0 – more sensitive than the anatomical criteria RECIST 1.1. According to PET/CT with 18F-FDG in patients with NSCLC and a mutation in the EGFR gene, the effect of combined therapy of TKI in combination with bevacizumab significantly exceeds not only the result of targeted monotherapy, but also the effect of chemotherapeutic treatment of patients in the control group.
Quantitative assessment of myocardial blood flow by dynamic single photon emission computed tomography: relationship with ECG changes and biochemical markers of damage in patients with acute myocardial infarction
Authors: Mochula A. V. , Mochula O. V. , Maltseva A. N. , Suleymanova A. S. , Kapilevich N. A. , Ryabov V. V. , Zavadovsky K. V. 
Published: October 2023

Aim: To study the relationship of microcirculatory changes in coronary bed and electrocardiographic and laboratory signs of damage to myocardium in patients with acute myocardial infarction (AMI).Methods. The observational study included patients with newly emerged AMI. Depending on the ECG changes, the patients were divided into two groups: 1) with ST segment elevation (n = 75) (STEMI) and 2) without ST segment elevation (n = 44) (NSTEMI). All patients underwent electrocardiography, analysis of biochemical markers of myocardial damage, dynamic single photon emission computed tomography (SPECT) and myocardial perfusion imaging.Results. The study included 119 patients (age 62.5 ± 10.4 years, 63% men). STEMI patients had heavier perfusion defects at rest, 5.00 (3.00;9.00) and 0.00 (0.00;1.00), and after pharmacological stress test, 7.00 (5.00;13.00) and 2.50 (0.00;5.00), also they had more reduced stress myocardial blood flow (MBF), 1.09 (0.83;1.59) and 1.67 (1.36;2.46) ml/min/g, flow difference (FD), 0.36 (0.01;0.72) and 1.14 (0.63;1.72) ml/min/g, and myocardial flow reserve (MFR), 1.78 (1.11;2.19) and 2.57 (2.13;3.31), according to compared to NSTEMI patients. Correlation analysis revealed significant relationships between stress MBF and CPK after 24 hours and 4 days: r = –0.34 and r = = –0.31, troponin I upon admission and after 24 hours – r = –0.4 and r = –0.3; MFR and FD and troponin I upon admission – r = –0.41 and r = –0.41.Conclusion. Quantitative parameters of myocardial perfusion determined by early dynamic myocardial SPECT are associated with electrocardiographic changes and biochemical markers of myocardial damage and allow an adequate assessment of the severity of the disease in patients with AMI.
Indicators of global myocardial work of the left ventricle during exercise stress echocardiography in the diagnosis of stable coronary heart disease
Authors: Alekhin M. N. , Ivanov S. I. , Radova N. F. 
Published: October 2023

Aim: To determine the possibility of identifying patients with significant coronary artery disease (CAD) by evaluation of the global left ventricular (LV) myocardial work indicators by constructing pressure-strain loops during exercise stress echocardiography.Material and Methods. The study included 136 patients aged 36 to 84 years, of which 97 (71%) men, with suspected or previously confirmed CAD, who underwent stress echocardiography on the treadmill according to the Bruce protocol. LV myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW) and global myocardial work efficiency (GWE) were evaluated using the technique of constructing pressure-strain loops at rest and at peak exercise. All patients underwent selective coronary angiography, according to the results of which they were divided into 3 groups: 51 patients without coronary artery lesions – the control group, 57 patients with single-vessel CAD and 28 patients with multi-vessel CAD. Significant lesion was defined as ≥ 70% artery luminal narrowing. All tests were two-sided and P-values < 0.05 were considered statistically significant.Results. Compared with the control group, patients with single-vessel CAD at rest had significantly less GWE and more GWW. In these patients GWI, GCW and GWE at peak exercise were significantly lower, and GWW was significantly higher. In patients with multi-vessel CAD, all global LV myocardial work indicators significantly differed from the control group both at rest and at peak exercise. The optimal cutoff value of GWI at peak exercise to predict significant CAD was 2553 mmHg% with a sensitivity of 62% and a specificity of 95% (AUC 0.79 ± 0.05, p < 0.001).Conclusions. The evaluation of global LV myocardial work indicators by constructing pressure-strain loops can be used in exercise stress echocardiography to improve the selection of patients requiring coronary intervention.
Valls Prieto, J. (2021). Inteligencia artificial, derechos humanos y bienes jurídicos. Cizur Menor (Navarra): Aranzadi (Thomson Reuters). ISBN: 9788413459370. 146 páginas
Authors: Sánchez Barrilao Juan Francisco 
Published: October 2023

Recensión a la monografía del profesor Valls Prieto, que lleva por título Inteligencia artificial, derechos humanos y bienes jurídicos [Cizur Menor (Navarra): Aranzadi (Thomson Reuters), 2021, ISBN: 9788413459370].
Trial pitfall traps of the Middle Ages on the example of a group of pits Kogonchinskoye 18
Authors: Balaba Inna , Kardash Oleg , Palyanov Petr 
Published: October 2023

Летом 2018 г. в Сургутском районе ХМАО-Югры были проведены археологические раскопки группы впадин Когончинское 18. Выявлены и изучены остатки двух сооружений. Предположительно, это действовавшая ловчая яма и незавершенная, между которыми находились остатки кострища с костями животных. Материалы позволяют воссоздать форму и размеры одного из сооружений. Возраст объекта, вероятно, локализуется в пределах XII–XIV вв. Авторами выдвинута гипотеза о функционировании одиночных ям-ловушек как пробных сооружений для определения эффективности охоты на новых территориях.
Analisis Flypaper Effect terhadap Belanja dan Kinerja Keuangan Daerah di Kabupaten Jayapura Tahun 2022
Authors: Situmorang Santi Elisabet 
Published: October 2023

Fenomena flypaper menjadi persoalan utama bagi setiap pemerintah daerah baik provinsi, kabupaten dan kota di Indonesia termasuk Kabupaten Jayapura. Alasannya persentasi kecilnya kontribusi Pendapatan Asli Daerah (PAD) terhadap Anggaran Pendapatan Belanja Daerah (APBD) Kabupaten Jayapura berdampak pada minimnya inovasi terhadap penggunaan anggaran di wilayah tersebut. Kontribusi dari PAD di Kabupaten Jayapura yang hanya sekitar 11,3 persen dimana sisanya sekitar 89,7 persen ditopang oleh Anggaran Pendapatan Belanja Negara (APBN) yang uangnya berasal dari pemerintahan pusat. Asumsi terhadap terjadinya flypaper yang terjadi di Pemerintah Daerah Kabupaten Jayapura terjadi karena dua kondisi. Tujuan penelitian ini adalah untuk menjelaskan kondisi eksisting terjadinya flypaper dan efek yang ditimbulkan serta inovasi dalam mengatasi flypaper effect. Metode penelitian dalam paper ini adalah kualitatif dengan analisis deskriptif. Hasil dari penelitian ini menjelaskan situasi Flypaper Effect di Kabupaten Jayapura, tantangan meningkatkan PAD di Kabupaten Jayapura dan inovasi dalam meningkatkan PAD melalui BUMD
Implementation of AI Chatbot Application for Social Anxiety Problem
Authors: Dewi Melisa , Fahmi Hasanul 
Published: October 2023

<p class="Abstract">The past decade has witnessed the rapid development of <a title="Learn more about Artificial Intelligence from ScienceDirect's AI-generated Topic Pages" href="https://www.sciencedirect.com/topics/computer-science/artificial-intelligence">Artificial Intelligence</a> (AI)[1]. AI nowadays, are becoming more popular and integrated in every aspect of the world. Using Ai chatbot as a companion partner has been a thing since a few years ago, but with the development of AI, it is possible to inject personality into those chatbots now. With the increasing growth of social anxiety issues, it is possible to implement AI chatbot as a way to train social skills into people. Past researches have already created a chatbot that is solely for the purpose of depression in a one-on-one chatting environment. In order to create a working training regime, it is necessary to give the user the ability to change from a fully AI environment to slowly integrate with humans. The present paper considers the ability of personality trained AI chatbots and environment as a way to help people learn to socialize. This research aims to help provide a cheaper and reliable alternative for therapists by using AI chatbots as a guide for socially anxious people.</p>