bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Allergic Diseases During the COVID-19 Pandemic: A Systematic Review
Authors: Erlanova K.E. , Kemelbekova N.A. , Izmailovich M.R. , Koshkarbayeva B.S. , Dedova O.Yu. , Skvortsova A.V. , Umirbaeva A.I. , Abdushukurova G.Z. , Tanriverdiev K.F. 
Published: October 2023

In addition to the COVID-19 pandemic, there is another pandemic on Earth, which is inexorably gaining momentum. The World Health Organization has called the XXI century the “century of allergy”. An increase in morbidity is recorded everywhere (up to 40 % of patients), every third inhabitant of the planet suffers from allergic rhinitis and every tenth — from asthma. Currently, it is known that allergic reactions are observed in 0.2–20.4 % of patients with coronavirus infection. Allergic symptoms in those infected with coronavirus manifest themselves in different ways and can serve as markers of the severity of the disease. This article provides information about the possible impact of coronavirus infection on the course of the most common allergic conditions, such as bronchial asthma and urticaria. The search for publications was carried out in Russian and English in the databases PubMed, Google Scholar, eLibrary.ru and “CyberLeninka” from January 1, 2019 to April 1, 2023, using keywords: “bronchial asthma”, “urticaria”, “COVID-19”, “coronavirus infection”. In accordance with the inclusion criteria, 29 studies have been included in the review. The results of a systematic analysis of the literature are presented, with a description of the pathogenetic mechanisms and clinical aspects. The data obtained can serve as a basis for a more in-depth understanding of the role of atopy as a premorbid background for infectious diseases during a pandemic.
RP-HPLC Method Development and Validation for Determination of Abemaciclib in Bulk Drug Substance and Pharmaceutical Dosage Forms
Authors: Maithani M. , Dwivedi D.K. 
Published: October 2023

A simple, economic, rapid and precise method for the quantification of Abemaciclib in bulk drug substance and pharmaceutical dosage forms was developed and validated using RP-HPLC. The chromatographic separation was achieved using Ascentis® C-18 HPLC column (250mm x 4.6mm i.d., particle size 5µ) with mobile phase containing 0.5% TFA: methanol: acetonitrile (35:45:20 v/v/v) with flow rate of 1.2mL/ min was used and effluents were monitored at 295nm. The retention time of Abemaciclib were found to be 3.72 min. The linearity was in the range of 6-42μg/mL. The limit of detection and limit of quantification were found to be 0.6 and 1.8 µg/mL, respectively. The % recoveries were found to be in the range of 99.65±0.77.
Keywords: Abemaciclib, Estimation, Bulk drug substance, Pharmaceutical dosage forms
Por um mundo onde muitos mundos possam existir: patrimônio imaterial e música afro-brasileira na escola
Authors: Maciel do Carmo Raiana , Santana Sales Marcos 
Published: October 2023

O objetivo deste artigo é apresentar uma proposta pedagógico-musical voltada para os anos finais do Ensino Fundamental, a qual contempla manifestações da cultura afro-brasileira que se constituem como patrimônios imateriais do Brasil, registrados pelo Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN). Nessa perspectiva, tal proposta aborda três atividades que envolvem o Jongo do Sudeste, o Samba de Roda do Recôncavo Baiano e o Maracatu de Baque Virado. Cada atividade abrange uma contextualização histórica e cultural destes patrimônios, assim como momentos em que são trabalhados aspectos da apreciação, da performance e da criação musical. Ao contemplar o rico patrimônio imaterial do Brasil, fortalecemos as múltiplas possibilidades de educação musical nas escolas e valorizamos a produção cultural afro-brasileira e dos seus descendentes.
PENGARUH IKLAN HIJAU (GREEN ADVERTISING) DAN CITRA MEREK HIJAU (GREEN BRAND IMAGE) TERHADAP KEPUTUSAN PEMBELIAN PRODUK RAMAH LINGKUNGAN (GREEN PRODUCT)
Authors: Kurnia Kurnia , Astaginy Niar , Ismanto Ismanto 
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh iklan hijau (green advertising) dan citra merek hijau (green brand image) terhadap keputusan pembelian produk ramah lingkungan (green product). Penelitian ini merupakan penelitian kuantitatif dengan teknik pengumpulan data menggunakan kuesioner dengan skala likert. Populasi dalam penelitian ini adalah seluruh konsumen Garnier di Kabupaten Kolaka dan diambil 60 responden dengan menggunakan teknik purposive sampling. Teknis analisis yang digunkan untuk menguji hipotesis adalah metode Structural Equation Modeling (SEM) dengan teknik analisis data menggunakan Partial Least Square (PLS). Hasil analisis menunjukkan bahwa iklan hijau (green advertising) terbukti memiliki pengaruh signifikan terhadap keputusan pembelian produk ramah lingkungan (green product) pada brand Garnier. Hal ini dibuktikan dengan t-hitung atau t-statistik yaitu 3,844 lebih tinggi dari nilai t-tabel yaitu 1,672 dan pada variabel citra merek hijau (green brand image) menunjukkan pengaruh positif dan signifikan terhadap keputusan pembelian produk ramah lingkungan karena nilai t-hitung atau t-statistik yaitu sebesar 5,288 lebih tinggi dari nilai t-tabel yaitu 1,672. Maka dapat disimpulkan kedua variabel dependen berpengaruh positif dan signifikan terhadap variabel independen.Kata Kunci: Iklan hijau; citra merek hijau; keputusan pembelian produk ramah lingkungan.
Upaya Peningkatan Kreativitas Belajar Siswa melalui Model Project Based Learning (PjBL) pada Mata Pelajaran IPA di Kelas IV SDN Simpenan
Authors: Agustin Laila , Sutisnawati Astri , Hamdani Maula Luthfi 
Published: October 2023

This study was motivated by the low learning creativity of students in science subjects in class IV SDN Simpenan so that it requires improvement to increase learning creativity. The purpose of this study is to describe the planning and implementation of science learning using the project-based learning (PjBL) model to improve student learning creativity and describe the increase in student learning creativity after using the PjBL model in science subjects. The subjects of this study were fourth grade students of SDN Simpenan, totaling 22 students. The type of research used is Kemmis and Mc Taggart design classroom action research which consists of four stages, namely planning, implementation, observation, and reflection. Data were collected using observation and documentation techniques and then processed using descriptive statistical techniques. The results of this study will be described regarding the planning and implementation of science learning using the PjBL model to increase student learning creativity and increase student learning creativity after using the PjBL model in science subjects
[Penelitian ini dilatarbelakangi oleh rendahnya kreativitas belajar siswa pada mata pelajaran IPA di kelas IV SDN Simpenan sehingga memerlukan perbaikan untuk meningkatkan kreativitas belajar. Tujuan dari penelitian ini adalah untuk mendeskripsikan perencanaan dan pelaksanaan pembelajaran IPA meng-gunakan model Project Based Learning (PjBL) untuk meningkatkan kreativitas belajar siswa serta mendeskripsikan peningkatan kreativitas belajar siswa setelah digunakan model PjBL dalam mata pelajaran IPA. Subjek dari penelitian ini adalah siswa kelas IV SDN Simpenan yang berjumlah 22 siswa. Jenis penelitian yang digunakan adalah penelitian tindakan kelas desain Kemmis dan Mc Taggart yang terdiri dari empat tahap yaitu perencanaan, pelaksanaan, observasi, dan refleksi. Data dikumpulkan menggunakan teknik observasi dan dokumentasi kemudian diolah menggunakan teknik statistik deskriptif. Hasil penelitian menunjukkan pada pra siklus nilai rata-rata yang diperoleh adalah 2,28 sehingga kreativitas belajar siswa pada pra siklus masuk dalam kriteria kurang. Pada siklus I nilai rata-rata yang diperoleh adalah 3,08 dan masuk dalam kriteria baik. Untuk siklus II nilai rata-rata yang diperoleh adalah 3,53 dan masuk dalam kriteria baik. Berdasarkan hasil penelitian dapat disimpulkan bahwa model PjBL dapat meningkatkan kreativitas belajar siswa kelas IV SDN Simpenan pada mata pelajaran IPA]
Effect of yogurt on fluoride induced toxicity of plasma markers of kidney in rabbits
Authors: Sallam Abdul , Bughio Shamsuddin , Buriro Rehana , Jamali Muneer Ahmed , Mughal Gulfam Ali , Arain Muhammad Bilawal , Lanjar Zainab 
Published: October 2023

Fluoride (F) is one of the major chemical substances that damage the renal tissue prevention tubular reabsorption, increasing the excretion of sodium (Na+) and chloride (cl-), and enhancing creatinine (Cr), uric acid (UA), blood urea nitrogen (BUN) and potassium (K+) level. Results revealed that on 16th day in groups B, D, E and G, Cr. values were significantly (P˂0.05) increased on 31st day in group-F, Cr. value was significantly (P˂0.05) decreased, whereas, in groups-B, D, E and G, Cr. values were significantly increased (P˂0.05). On 16th and 31st day, in yogurt-treated groups i.e.- C and F, UA values were significantly (P˂0.05) decreased, whereas, in groups B, D, E and G, UA values were significantly (P˂0.05) increased. On 16th and 31st day, in groups-B, D, E and G BUN level was significantly (P˂0.05) increased. On 16th and 31st day in groups-B and E, Na+ level was significantly (P˂0.05) decreased. Whereas, in groups C, D, F and G, Na+ level was significantly (P˂0.05) increased. Likewise, on 16th and 31st day, in groups-B, D, E and G, K+ level was significantly (P˂0.05) increased. On 16th day in groups-B and E, cl- level was significantly (P˂0.05) decreased. While, in groups- F and G cl- level was significantly (P˂0.05) increased. On 31st in groups-B & E, cl- level was significantly (P˂0.05) decreased. While, in groups-C, D, F and G, cl- levels was significantly (P˂0.05) increased. It has been concluded that increased levels of sCr, UA, BUN, K+ and reduced levels of Na+ and cl- were observed in all fluoride treated groups. Yogurt-treated groups showed decreased levels of Cr, UA, BUN and K+ and increased levels of Na+ and Cl- in experimental rabbits
Effect of the inclusion of rumen-protected amino acids in the diet of growing beef cattle on animal performance and meat quality
Authors: Cabezas Almudena , De la Fuente Jesús , Díaz María Teresa , Bermejo-Poza Rubén , del Olmo Diego Martínez , Mateos Javier , Llanes Nuria , Jimeno Vicente 
Published: October 2023

IntroductionThis study investigated the impact of rumen-protected amino acids on beef cattle's growth, fattening performance, and meat quality.MethodsTwo groups of 40 Montbeliard steers (237.8 ± 30 kg body weight) were housed separately and fed, with mono-tunnel feeders, either a control diet (CON) or a diet containing rumen-protected lysine and methionine with 3% less crude protein (APR). Feed consumption and weight were tracked in all animals, and meat quality analysis focused on the longissimus muscle, with 10 steers randomly selected from each treatment.Results and discussionResults for overall performance revealed no significant differences in body weight, average daily gain (ADG), and concentrate conversion ratio between the CON and APR diets (p &gt; 0.05). However, during the final 90 days of the trial, the APR group showed significantly higher ADG (p &lt; 0.05) than the CON group, while the concentrate conversion ratio was significantly higher (p &lt; 0.05) in the CON group compared to the APR group. The hot carcass weight, dressing percentage, and carcass conformation did not differ significantly between the CON and APR diets (p &gt; 0.05). There was a slight tendency (p = 0.06) for higher fatness score in the CON group. Regarding meat composition, the diet did not significantly affect proximate composition, but a tendency (p = 0.059) for higher crude protein content in APR cattle's meat compared to the CON group was observed. The APR meat showed slightly lower levels of C17:1 (0.56% vs. 0.72%) and C18:1n9 (31.7% vs. 34%). There was a tendency for C14:0 to be lower (P = 0.07), and for C16:0, C18:2 and polyunsaturated fatty acids (PUFA) to be greater in meat from cattle fed APR compared to CON. However, meat quality attributes like pH, water-holding capacity, color, and texture were similar in both CON and APR groups (p &gt; 0.05). The findings indicate that utilizing rumen-protected amino acids enables formulating diets with reduced crude protein levels while enhancing nitrogen utilization efficiency for protein synthesis in intensively reared steers. Importantly, these dietary improvements do not adversely affect meat quality.
Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia
Authors: Lopez-Lopez Jose P. , Gonzalez Ana María , Lanza Paola , Martinez-Bello Daniel , Gomez-Arbelaez Diego , Otero Johanna , Cohen Daniel D. , Perez-Mayorga Maritza , Garcia-Peña Angel A. , Rangarajan Sumathy , Yusuf Salim , Lopez-Jaramillo Patricio 
Published: October 2023

BackgroundAbdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the WC cut-off points to predict major cardiovascular events (MACE) and incident diabetes.MethodsWe analyzed data from the cohort PURE study in Colombia. WC cut-off points were defined according to the maximum Youden index. Multivariate logistic regression was used to obtain associations between WC and MACE, diabetes, and cumulative incidence of outcomes visualized using Kaplan-Meier curves.ResultsAfter a mean follow-up of 12 years, 6,580 individuals with a mean age of 50.7 ± 9.7 years were included; 64.2% were women, and 53.5% were from rural areas. The mean WC was 85.2 ± 11.6 cm and 88.3 ± 11.1 cm in women and men, respectively. There were 635 cases of the MACE composite plus incident diabetes (5.25 events per 1,000 person-years). Using a cut-off value of 88.85 cm in men (sensitivity = 0.565) and 85.65 cm in women (sensitivity = 0.558) resulted in the highest value for the prediction of the main outcome. These values were associated with a 1.76 and 1.41-fold increased risk of presenting the composite outcome in men and women, respectively.ConclusionsWe defined WC cut-off points of 89 cm in men and 86 cm in women to identify the elevated risk of MACE and incident diabetes. Therefore, we suggest using these values in cardiovascular risk assessment in Latin America.
Machine learning-based prediction of acute mortality in emergency department patients using twelve-lead electrocardiogram
Authors: Chang Po-Cheng , Liu Zhi-Yong , Huang Yu-Chang , Hsu Yu-Chun , Chen Jung-Sheng , Lin Ching-Heng , Tsai Richard , Chou Chung-Chuan , Wen Ming-Shien , Wo Hung-Ta , Lee Wen-Chen , Liu Hao-Tien , Wang Chun-Chieh , Kuo Chang-Fu 
Published: October 2023

BackgroundThe risk of mortality is relatively high among patients who visit the emergency department (ED), and stratifying patients at high risk can help improve medical care. This study aimed to create a machine-learning model that utilizes the standard 12-lead ECG to forecast acute mortality risk in ED patients.MethodsThe database included patients who visited the EDs and underwent standard 12-lead ECG between October 2007 and December 2017. A convolutional neural network (CNN) ECG model was developed to classify survival and mortality using 12-lead ECG tracings acquired from 345,593 ED patients. For machine learning model development, the patients were randomly divided into training, validation and testing datasets. The performance of the mortality risk prediction in this model was evaluated for various causes of death.ResultsPatients who visited the ED and underwent one or more ECG examinations experienced a high incidence of 30-day mortality [18,734 (5.42%)]. The developed CNN model demonstrated high accuracy in predicting acute mortality (hazard ratio 8.50, 95% confidence interval 8.20–8.80) with areas under the receiver operating characteristic (ROC) curve of 0.84 for the 30-day mortality risk prediction models. This CNN model also demonstrated good performance in predicting one-year mortality (hazard ratio 3.34, 95% confidence interval 3.30–3.39). This model exhibited good predictive performance for 30-day mortality not only for cardiovascular diseases but also across various diseases.ConclusionsThe machine learning-based ECG model utilizing CNN screens the risks for 30-day mortality. This model can complement traditional early warning scoring indexes as a useful screening tool for mortality prediction.
How safe and effective are paediatric virtual fracture clinics? A systematic review
Authors: Waite Emma , Ahmed Zubair 
Published: October 2023

IntroductionVirtual fracture clinics (VFC) involve a consultant-led multidisciplinary team meeting where cases are reviewed before a telephone consultation with the patient. VFCs have the advantages of reducing waiting times, outpatient appointments and time off school compared to face-to-face (F2F) fracture clinics. There has been a surge in VFC use since the COVID-19 pandemic but there are still concerns over safety in the paediatric population. Fractures make up a large burden of paediatric injuries, therefore research is required on the safety and efficacy of paediatric VFCs. This systematic review will look at the safety and effectiveness of paediatric VFCs, as well as determine the cost-effectiveness and parent preferences.MethodsAs per the PRISMA guidelines two independent reviewers searched the following databases: Medline, Embase and Web of Science. Studies were included if children under 18 years old presented to A&amp;E with a suspected or confirmed simple un-displaced fracture and were referred to a VFC. The primary outcomes assessed were effectiveness and safety, with the secondary outcomes of cost-effectiveness and parent satisfaction.ResultsSix studies met the inclusion criteria for this systematic review. There was a high rate of direct discharge from the VFC leading to reduced outpatient appointments. All patients were seen within 72 h of presentation. There were limited incidences of missed fractures and the rates of re-presentation were similar to that of F2F orthopaedic clinics. There were significant cost savings for the hospitals and high parent satisfaction.DiscussionVFCs have shown to be safe and effective at managing most stable, low operative risk paediatric fractures. Safety must be ensured with a telephone helpline and an open return to fracture clinic policy. More research is needed into specific paediatric fracture types to be managed in the VFC.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#searchadvanced, identifier: CRD42023423795.
Relationship between weight-adjusted waist circumference index and prevalence of gallstones in U.S. adults: a study based on the NHANES 2017-2020
Authors: Ke Bin , Sun Ying , Dai Xin , Gui Yang , Chen Song 
Published: October 2023

ObjectiveWe aimed to assess the association between weight-adjusted waist circumference index (WWI) and gallstone prevalence in US adults.MethodsWe selected individuals from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020 and used logistic regression analyses, subgroup analyses, and dose-response curves to assess the association between WWI and gallbladder stone prevalence and age, sex, and ethnicity.ResultsA total of 7971 participants aged ≥20 years were enrolled in our study; 828 patients had a self-reported history of gallstones. After correcting for confounders, for each unit of WWI after Ln conversion, the prevalence of gallbladder stones increased by 34% (OR=1.34, 95% CI:1.20, 1.50). Dose-response curves showed a positive correlation between WWI and gallbladder stone prevalence.According to the subgroup analysis, the positive association between TyG index and high-frequency HI was more significant in males(OR=1.34, 95% CI:1.07, 1.69), &lt;40 years old(OR=1.42, 95% CI:1.18, 1.71), white people Americans(OR=1.35, 95% CI:1.08, 1.68) and other races(OR= 1.56, 95% CI:1.13, 2.14).ConclusionHigher WWI was positively associated with the prevalence of gallbladder stones and was associated with gender, age, and ethnicity. This is noteworthy, although a causal relationship could not be established.
In the skin lesions of patients with mycosis fungoides, the number of MRGPRX2-expressing cells is increased and correlates with mast cell numbers
Authors: Hu Man , Pyatilova Polina , Altrichter Sabine , Sheng Caibin , Liu Nian , Terhorst-Molawi Dorothea , Lohse Katharina , Ginter Katharina , Puhl Viktoria , Maurer Marcus , Metz Martin , Kolkhir Pavel 
Published: October 2023

BackgroundMycosis fungoides (MF) is an indolent T-cell lymphoma that mainly affects the skin and presents with itch in more than half of the patients. Recently, the expression of Mas-related G protein-coupled receptor X2 (MRGPRX2), a receptor of mast cell (MC) responsible for the IgE-independent non-histaminergic itch, has been shown in lesional skin of patients with pruritic skin diseases, including chronic urticaria, prurigo, and mastocytosis. As of yet, limited knowledge exists regarding the MRGPRX2 expression in the skin of patients with MF.ObjectivesTo investigate the number of MRGPRX2-expressing (MRGPRX2+) cells in the skin of patients with MF and its correlation with clinical and laboratory characteristics of the disease.MethodsMRGPRX2 was analyzed in lesional and non-lesional skin of MF patients and healthy skin tissues by immunohistochemistry. Co-localization of MRGPRX2 with the MC marker tryptase was assessed by immunofluorescence. Public single-cell RNAseq data was reanalyzed to identify the MRGPRX2 expression on the distinct cell types.ResultsIn lesional skin of MF patients, MRGPRX2+ cell number was higher than in non-lesional skin and healthy control skin (mean:15.12 vs. 6.84 vs. 5.51 cells/mm2, p=0.04), and correlated with MC numbers (r=0.73, p=0.02). MC was the primary cell type expressing MRGPRX2 in MF patients. The ratio of MRGPRX2+ MCs to MRGPRX2+ cells in lesional and non-lesional skin correlated with the severity of disease (r=0.71, p=0.02 and r=0.67, p=0.03, respectively).ConclusionsOur findings point to the role of MRGPRX2 and MC in the pathogenesis of MF that should be investigated in further studies.