bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overview and characterization of penile cancer content across social media platforms
Authors: Ortiz-Guerra Ruben Alejandro , Jaime-Casas Salvador , Martinez-Cannon Bertha Alejandra , Ariza-Avila Jose C. , González-Morales Ana P. , Bardan-Duarte Andrea , Remolina-Bonilla Yuly A. , Spiess Philippe E. , Bourlon Maria T. 
Published: December 2023

BackgroundSocial media platforms (SMP) are an emerging resource that allows physicians, patients, and families to converse on cancer prevention, diagnosis, and treatment. We aimed to characterize penile cancer (PC) content shared on SMP.MethodsWe searched PC posts on Twitter, Facebook, and Instagram from July 1st, 2021, through June 30th, 2022. Two independent, blinded reviewers analyzed the hashtags: #PenileCancer, #PenileCancerAwareness, and #PenileNeoplasm. Descriptive statistics were used for posts characterization, Pearson´s correlation coefficient for associations, and Cohen’s weighted kappa coefficient for inter-rater agreement rate.ResultsA total of 791 posts were analyzed, with Twitter accounting for 52%, Facebook for 12.2%, and Instagram for 35.5%, and. Most posts originated from high-income countries, such as the United Kingdom (48.8%). We found no correlation between the number of posts with PC incidence (p = 0.64) or users on SMP (p = 0.27). Most accounts were classified as “support and awareness communities” (43.6%) and “physicians and clinical researchers” (38.2%). Urology was the most common medical specialty to post (60.9%), followed by oncology (11.3%). Most posts were classified as “prevention and awareness for users” (45.1%). Global inter-reviewer agreement rate was almost perfect (k=0.95; p ≤ 0.01). On Twitter, “physicians and clinical researchers” shared more content on “treatment updates and medical papers published in medical journals,” while on Facebook and Instagram, “support and awareness communities” focused on “personal and support comments.”ConclusionOverall, the number of PC posts was low compared to other neoplasms across the SMP evaluated in this study. “Physicians and clinical researchers” shared more content on Twitter, while “support and awareness communities” on Facebook and Instagram. Encouraging the use of a common SMP among the medical community and general users could lead to a more effective communication between physicians, patients, and support groups, and to increased awareness of PC.
Impact of the COVID-19 pandemic on antidepressant and antipsychotic use among children and adolescents: a population-based study
Authors: Antoniou Tony , Pajer Kathleen , Gardner William , Penner Melanie , Lunsky Yona , Tadrous Mina , Mamdani Muhammad , Gozdyra Peter , Juurlink David N. , Gomes Tara 
Published: December 2023

BackgroundThe COVID-19 pandemic was associated with increases in the prevalence of depression, anxiety and behavioural problems among children and youth. Less well understood is the influence of the pandemic on antidepressant and antipsychotic use among children. This is important, as it is possible that antidepressants and antipsychotics were used as a “stop-gap” measure to treat mental health symptoms when in-person access to outpatient care and school-based supportive services was disrupted. Furthermore, antipsychotics and antidepressants have been associated with harm in children and youth. We examined trends in dispensing of these medications two years following the pandemic among children 18 years of age and under in Ontario, Canada.MethodsWe conducted a population-based time-series study of antidepressant and antipsychotic medication dispensing to children and adolescents ≤18 years old between September 1, 2014, and March 31, 2022. We measured monthly population-adjusted rates of antidepressant and antipsychotics obtained from the IQVIA Geographic Prescription Monitor (GPM) database. We used structural break analyses to identify the pandemic month(s) when changes in the dispensing of antidepressants and antipsychotics occurred. We used interrupted time series models to quantify changes in dispensing following the structural break and compare observed and expected use of these drugs.ResultsOverall, we found higher-than-expected dispensing of antidepressants and antipsychotics in children and youth. Specifically, we observed an immediate step decrease in antidepressant dispensing associated with a structural break in April 2020 (−55.8 units per 1,000 individuals; 95% confidence intervals [CI] CI: −117.4 to 5.8), followed by an increased monthly trend in the rate of antidepressant dispensing of 13.0 units per 1,000 individuals (95% CI: 10.2–15.9). Antidepressant dispensing was consistently greater than predicted from September 2020 onward. Antipsychotic dispensing increased immediately following a June 2020 structural break (26.4 units per 1,000 individuals; 95% CI: 15.8–36.9) and did not change appreciably thereafter. Antipsychotic dispensing was higher than predicted at all time points from June 2020 onward.ConclusionWe found higher-than-expected dispensing of antidepressants and antipsychotics in children and youth. These increases were sustained through nearly two years of observation and are especially concerning in light of the potential for harm with the long-term use of antipsychotics in children. Further research is required to understand the clinical implications of these findings.
Effect of Danshen for improving clinical outcomes in patients with bladder cancer: a retrospective, population-based study
Authors: Chen Yi-Hsin , Chen Chih-Tsung , Wu Han-Ping 
Published: December 2023

Introduction: Traditional Chinese Medicine (TCM) has a broad application in healthcare, with Danshen being a notable herb used in Eastern medicine for cancer treatment. This study aims to explore the relationship between Danshen use and cardiovascular risks among bladder cancer patients.Methods: Patients were selected based on a confirmed diagnosis of bladder cancer with specific inclusion and exclusion criteria to control for certain comorbidities and treatments. Utilizing Taiwan’s National Health Insurance data from 2003 to 2013, this retrospective, population-based study identified three groups: 525 patients treated with Danshen, 6,419 patients not treated with TCM, and 4,356 patients treated with TCM but not with Danshen. The Cox proportional hazard model was employed to estimate the risks of Major Adverse Cardiovascular Events (MACE) and mortality while accounting for various confounders.Results: The overall incidence of MACEs was significantly lower in the Danshen group (5%) compared to the TCM (8.1%) and non-TCM (9.9%) groups (p &lt; 0.001). The Cox model revealed that bladder cancer patients treated with Danshen had the lowest risk of MACE (adjusted hazard ratio, 0.56; 95% confidence interval, 0.38–0.84) and all-cause mortality (adjusted hazard ratio, 0.60; 95% confidence interval, 0.44–0.82).Discussion: The findings suggest that Danshen reduces the risk of MACE and all-cause mortality in bladder cancer patients, highlighting its potential benefits. This underpins the necessity for further research to substantiate the cardiovascular benefits of Danshen in bladder cancer patients and potentially broaden its application in oncology healthcare.
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Authors: Guo Yuhuai , Gao Bowen , Sun Shilin , Li Jianuo , Lv Xiaolin , Yin Hongna , Sun Zhongren , Cai Shuo 
Published: December 2023

Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation therapy has shown great potential in the reconstruction of damaged spinal cords and promoting functional recovery. However, there is a lack of frontiers and futures analysis in the study of cell transplantation in TSCI.Methods: We used CiteSpace, VOSviewer and biblilometrix R package to perform bibliometric analysis on cell transplantation in TSCI from 2013 to 2023. Bibliometric records were extracted from English articles and reviews from the Web of Science core collection.Results: The bibliometric analysis included 284 papers published in 154 journals by 1,780 authors from 487 institutions in 41 countries and regions. The number of articles published in the past decade has fluctuated slightly, while the number of article citations has steadily increased. Mainland China and the United States are the leading countries and regions in this field, with the National Natural Science Foundation of China being the most funded foundation, and the United States being the country with the most funded articles. The University of Toronto in Canada is a prolific institution. Michael G. Fehlings has published the most articles, and D Michele Basso is the most cited author. Cell transplantation is the most published journal, and the Journal of Neurotrauma is the most cited journal. Cell and tissue engineering and clinical neurology are the basic disciplines in this field, and cutting-edge disciplines include developmental biology, biochemistry and molecular biology, and materials science and multidisciplinary. This study also helps scholars understand the current hotspots and future trends in this field. Marrow stromal cells, glial progenitor, and cell therapy are current research hotspots in this field, while nerve regeneration, cell therapy, and the safety of transplantation of transplantation may be potential research directions in the future.Conclusion: Cell transplantation after TSCI is receiving increasing attention. Cell therapy is both the frontier and a possible future trend in TSCI research. In addition, glial progenitor and marrow stromal cells are also current research hotspots. Meanwhile, nerve regeneration and safety of transplantation may be potential research directions. These findings will help further deepen research on cell transplantation for TSCI in scientific work.
Internet-delivered therapist-assisted cognitive behavioral therapy for gambling disorder: a randomized controlled trial
Authors: Mide Mikael , Mattiasson Jessica , Norlin David , Sehlin Helena , Rasmusson Josefine , Ljung Sofia , Lindskog Amanda , Petersson Jonna , Saavedra Fanny , Gordh Anna Söderpalm 
Published: December 2023

ObjectivesCognitive behavioral therapy (CBT) is the most promising treatment for gambling disorder (GD) but only 21% of those with problematic gambling seek treatment. CBT over the Internet might be one way to reach a larger population. The aim of this study was to assess the effectiveness of Internet-delivered CBT with therapist guidance compared to an active control treatment.MethodsUsing a single-blinded design, 71 treatment-seeking gamblers (18–75 years) diagnosed with GD were randomized to 8 weeks of Internet-delivered CBT guided by telephone support, or 8 weeks of Internet-delivered motivational enhancement paired with motivational interviewing via telephone (IMI). The primary outcome was gambling symptoms measured at a first face-to-face assessment, baseline (treatment start), every 2 weeks, post-treatment, and 6-month follow-up. Gambling expenditures, time spent gambling, depression, anxiety, cognitive distortions, and quality of life were assessed as secondary outcomes. Analysis was performed on the full analysis sample (n = 60), with intention-to-treat sensitivity analyses (n = 69).ResultsIn the CBT group, 80% stayed in treatment until the final week, compared to 67% in IMI. Post-treatment and at 6-month follow-up, no differences were found between CBT and IMI for any outcome measure. An exploratory analysis of the total sample (n = 60) showed a significant effect of time during treatment on gambling symptoms (d, [95% CI] 0.52, [−1.15, 2.02]) and all secondary outcomes except the gambling diary (depression (0.89, [−1.07–2.65]); anxiety (0.69, [−1.20–2.38])); cognitive distortions (0.84, [−0.73–2.29]); quality of life (0.60, [−0.61–1.70])). Post-treatment, there were no clinical gambling symptoms in either group. Some deterioration was seen between post-treatment and 6-month follow-up on gambling symptoms (0.42, [−1.74–2.43]), depression (0.59, [−0.82–1.86]), and anxiety (0.30, [−0.99–1.48]). Additionally, it was observed that the largest reduction in gambling symptoms was between the first assessment and baseline.ConclusionBoth treatments offered in this study were effective at reducing gambling symptoms. It is also possible that the process of change started before treatment, which gives promise to low-intensity interventions for GD. Additional research is needed as this approach could be both cost-effective and has the potential to reach more patients in need of treatment than is currently possible.Clinical trial registration:https://www.isrctn.com/, identifier ISRCTN38692394.
“I was very sad, but not depressed”: phenomenological differences between adjustment disorder and a major depressive episode
Authors: Zapata-Ospina Juan Pablo , Jiménez-Benítez Mercedes , Fierro Marco 
Published: December 2023

IntroductionAdjustment disorder (AD) is a diagnosis that must be differentiated from major depressive episode (MDE) because of the therapeutic implications. The aim of this study is to understand the experience of patients who in their lifetime have been diagnosed with AD as well as MDE to establish the characteristics of each disorder.MethodsA descriptive phenomenological approach was used with in-depth interviews to four patients and the method proposed by Colaizzi to understand the experiences and reach the description of both disorders.ResultsThree women and one man, with advanced schooling were interviewed. The participants emphasized the existence of differences that were grouped in: the attribution made by the individual, the theme of cognitions, the variability in the course, the possibility of mood modulation, the syndrome severity, the presence of hopelessness and the perceived course.ConclusionPhenomenological differences were found in the subjective experience of MDE and AD. The MDE would be described as an intense state of generalized shutdown of the subject’s own life, with little response to events, and the AD, as a dynamic reaction attributed to a stressful event, with high variability in the course of symptoms due to the dependence on such event, with the preserved hope that it will end.
The bi-directional relationship between growth stunting and early childhood caries: a rapid review
Authors: Aulia Refine Nissa , Indriyanti Ratna , Setiawan Arlette Suzy 
Published: December 2023

ObjectiveThis review aims to determine the two-way relationship between stunting and ECC in developing countries worldwide.MethodsThe procedure in this study was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Rapid Review protocol. Article searches were carried out using databases Cochrane and PubMed. In addition, searches were also carried out using backward and forward snowballing techniques to identify articles that were not detected through database searches.ResultsNine observational epidemiological articles were found in children aged six months to six years, published in 2015–2020. Five articles discussed the features of ECC in stunted children, and the other five discussed stunting in children with caries in their primary teeth.ConclusionSeveral studies found associations between severe ECC and stunting, with ECC and stunting as both independent and dependent variables, suggesting a bi-directional relationship, also supported by literature on the physiological relationship between oral health and nutrition.
Sleep quality and subjective well-being in healthcare students: examining the role of anxiety and depression
Authors: Zhu Yihong , Meng Runtang , Jiang Chen , Yang Nongnong , Huang Mengyi , Wang Xiaowen , Zou Wenjing , Lou Chen , Xiao Ruohan , Lu Jingjing , Xu Jiale , Jiménez-Correa Ulises , Ma Haiyan , Spruyt Karen , Dzierzewski Joseph M. 
Published: December 2023

ObjectiveSleep issues, negative emotions, and health conditions are commonly co-occurring, whereas their associations among healthcare students have yet to be elucidated. This study aimed to examine whether anxiety and depression mediate the relationship between sleep quality and subjective well-being in healthcare students.MethodsA cross-sectional survey was conducted among Chinese healthcare students (N = 348). A battery of paper-and-pencil questionnaires—the Sleep Quality Questionnaire (SQQ), World Health Organization-Five Well-Being Index (WHO-5), and Patient Health Questionnaire-4 (PHQ-4) were applied. Descriptive analysis with means (standard deviations) and counts (proportions), Spearman correlation analysis between the SQQ, WHO-5, and PHQ-4, and mediation analysis via structural equation models were performed.ResultsCorrelation analysis revealed statistically significant associations between sleep quality, anxiety and depression, and well-being among healthcare students. Mediation analysis identified that poor sleep quality produced relatively low levels of self-reported well-being, which were entirely attributable to anxiety and depression.ConclusionSleep quality was associated with subjective well-being, and this interrelationship was fully mediated by anxiety and depression. Interventions aimed at promoting sleep quality of healthcare students may contribute to promoting their well-being by reducing anxiety and depression.
Comparative analysis of EZH2, p16 and p53 expression in uterine carcinosarcomas
Authors: Makk Evelin , Bohonyi Noémi , Oszter Angéla , Éles Klára , Tornóczky Tamás , Tóth Arnold , Kálmán Endre , Kovács Krisztina 
Published: December 2023

Introduction: The role of p16 and p53 immunohistochemistry in the diagnosis of rare and aggressive uterine carcinosarcoma (UCS) has been well established. However, enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a member of the polycomb group family is a relatively new biomarker, with limited published data on its significance in this tumor type. The goal of this study was to examine EZH2 expression in UCS and its components, in correlation with morphological features, and p16 and p53 staining patterns.Methods: Twenty-eight UCSs were included in the study. EZH2, p16 and p53 immunoreactivity were assessed independently by two pathologists in both tumor components (epithelial and mesenchymal). EZH2 and p16 immunostains were scored semiquantitatively: based on the percentage and intensity of tumor cell staining a binary staining index (“high- or low-expressing”) was calculated. The p53 staining pattern was evaluated as wild-type or aberrant (diffuse nuclear, null, or cytoplasmic expression). Statistical tests were used to evaluate the correlation between staining patterns for all three markers and the different tumor components and histotypes.Results: High EZH2 and p16 expression and aberrant p53 patterns were present in 89.3% 78.6% and 85.7% of the epithelial component and in 78.6%, 62.5% and 82.1% of the mesenchymal component, respectively. Differences among these expression rates were not found to be significant (p &gt; 0.05). Regarding the epithelial component, aberrant p53 pattern was found to be significantly (p = 0.0474) more frequent in the serous (100%) than in endometrioid (66.6%) histotypes. Within the mesenchymal component, p53 null expression pattern occurred significantly (p = 0.0257) more frequently in heterologous sarcoma components (71.4%) compared to the homologous histotype (18.8%).Conclusion: In conclusion, EZH2, p16 and p53 seem to play a universal role in the pathogenesis of UCS; however, a distinctive pattern of p53 expression appears to exist between the serous and endometrioid carcinoma components and also between the homologous and heterologous sarcoma components.
Sources of Ionizing Radiation Used in Modern and Advanced NBC Reconnaissance Devices (Lecture)
Authors: Vasilkovsky E. V. , Dikun A. V. , Vasyukevich I. G. 
Published: December 2023

The lecture is intended to prepare students studying under an additional professional advanced training program for military specialists in radiation safety for all branches of the Armed Forces of the Russian Federation, as well as to train officials responsible for organizing and ensuring radiation safety in military units and organizations of the Ministry of Defense of the Russian Federation. The lecture addresses three educational questions: 1. Accounting and control of radiation sources in the system of state accounting and control of radioactive substances and radioactive waste. 2. General requirements for the operation of radiation sources. 3. Operation of sealed radionuclide sources as part of the technical means of the RCB for intelligence and control.
Simpatik Education Model for Knowledge and Diversity of Food Intake for Stunting Toddlers in Kerinci Regency
Authors: Junita Junita , Rusmimpong Rusmimpong , Triana Winda 
Published: December 2023

Background: The problem of under-five nutrition is still a significant concern in developing countries. One of the main factors is the level of nutritional knowledge, so feeding toddlers is not appropriate and varied. Nutrition education must be packaged in an informative, interactive and accessible way at any time. This study aims to analyze the influence of website nutrition education on the knowledge and diversity of toddler intake, especially in Kerinci.
Method: This type of research is development research to see the effectiveness of the SIMPATIK site using a pre-experimental design, pre-post test only design, with 40 mothers under five who met the inclusion criteria at the Integrated Healthcare Center in the working area of the Kemantan in 2023.
Result: Data collection through interviews and assistance from the SIMPATIK website. Statistical test using Wilcoxon test with SPSS IBM series 21 software. The result is an influence of the SIMPATIK website on maternal nutrition knowledge (p= 0.000) with a difference of 15.38, and the diversity of food intake of toddlers (p= 0.000) with a difference of 2.20.
Conclusion: In conclusion, the SIMPATIK education model improves the nutritional knowledge of mothers under five and the diversity of food intake of toddlers stunting.