bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample
Authors: Bègue Indrit , Elandaloussi Yannis , Delavari Farnaz , Cao Hengyi , Moussa-Tooks Alexandra , Roser Mathilde , Coupé Pierrick , Leboyer Marion , Kaiser Stefan , Houenou Josselin , Brady Roscoe , Laidi Charles 
Published: December 2023

AbstractMultiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check (n = 662 subjects retained from initial n = 1452). Canonical correlation analyses (CCA) examined regional gray matter volumetric (GMV) differences in association to cognitive function (quantified with NIH Toolbox Cognition domain, NIH-TB), accounting for psychopathology severity, age, sex, scan location, and intracranial volume. Multivariate CCA uncovered a significant correlation between two components entailing a latent cognitive canonical (NIH-TB subscales) and a brain canonical variate (cerebellar GMV and intracranial volume, ICV), surviving bootstrapping and permutation procedures. The components correspond to partly shared cerebellar-cognitive function relationship with a first map encompassing cognitive flexibility (r = 0.89), speed of processing (r = 0.65), and working memory (r = 0.52) associated with regional GMV in crus II (r = 0.57) and lobule X (r = 0.59) and a second map including the crus I (r = 0.49) and lobule VI (r = 0.49) associated with working memory (r = 0.51). We show evidence for a structural subspecialization of the cerebellum topography for cognitive function in a transdiagnostic sample.
Neoichnological analysis of sea stars in the deep sea near the Aleutian Trench: behavioral insights from in situ observations
Authors: Miguez-Salas Olmo , Brandt Angelika , Moreau Camille 
Published: December 2023

AbstractThe study of biogenic structures (e.g., lebensspuren) produced by benthic fauna on the seafloor provides invaluable information about the behavior of their tracemakers. In the case of sea stars, most of the previous research has been focused on shallow-marine environments due to the extreme scarcity of data from deep-sea lebensspurens. Here, we examined sea star traces from six deep-sea stations (deeper than 4500 m) near the Aleutian Trench (North Pacific). A total of six families were identified from still images. The majority of them were not observed producing any lebensspuren or just pentameral impressions related to resting and feeding activities. Two members of the families Pterasteridae and Porcellanasteridae could be clearly characterized by a composite behavior resulting in contrasting lebensspuren morphotypes. A morphotype belonging to the genus Hymenaster undet. produced pentameral impressions (related to predation) and punctuated trails (related to podia locomotion). Members of the family Porcellanasteridae produced oval to circular impressions (that may be related to burrowing trails for the detection of organic matter), flat-shallow trails (related to podia locomotion), and irregular M-ridged trails (related to locomotion while feeding through the sediment interface). There is a severe scarcity of data related to the locomotion of past deep-sea Asteroidea (i.e., trace fossils) and their ichnotaxonomical classification. We discuss the implications of our results for the ichnofamily Biformitidae, as well as the importance of considering other features (e.g., podia impressions) rather than just hook-shaped traces related to arm locomotion.
Linear representations of fundamental groups of Klein surfaces derived from spinor representations of Clifford algebras
Authors: Tyszkowska Ewa 
Published: December 2023

AbstractWe study actions of multiplicative subgroups of Clifford algebras on Riemann surfaces. We show that every Klein surface of algebraic genus greater than 1 is isomorphic to the orbit space of such an action. We obtain linear representations of fundamental groups of Klein surfaces by using the spinor representations of Clifford algebras.
Large hairy armadillo Chaetophractus villosus: the most recent mammal invader in the binational Tierra del Fuego Island
Authors: Jaksic Fabian M. 
Published: December 2023

AbstractI reviewed the history of knowledge on large hairy armadillo Chaetophractus villosus in Patagonia and its current presence in Tierra del Fuego Island, a southernmost geographic region in South America shared by Argentina and Chile. My aim was to highlight what is known of this recent invasion, to identify knowledge advances and gaps, and to propose some new avenues of inquiry. This review reveals that studies on large hairy armadillo have covered the following topics: (a) introduction, spread, current distribution, and the role of physical and/or ecological barriers; (b) genetic profiling, which is ongoing and highly promising research for determining founding effects and genetic bottlenecks in an expanding alien population; (c) life history—including habitat, food, and time use, reproduction, behavior, and population dynamics; (d) interactions with sympatric consumer species—be them as mutualists or competitors—and with food plants and arthropod prey; (e) interactions with predators; (f) interactions with humans—including hunting, commercialization, facilitation, and interference; (g) an eyesore is the lack of an ecosystem approach to this invading species, because the large hairy armadillo may be deemed an ecosystem engineer, which profoundly alters its habitat and prey base and has close ties to human endeavors.
Production of cornelian cherry (Cornus mas L.) pulp powder by foam-mat drying: analysis of physicochemical and antioxidant properties
Authors: Kaba Beyza , Yıkılkan Yasemin , Pashazadeh Hojjat , Ali Redha Ali , Koca Ilkay 
Published: December 2023

Abstract
Cornelian cherry (Cornus mas L.) is a rich source of (poly)phenols such as phenolic acids, flavonoids, and anthocyanins that are known for their bioactivity. This study aimed to enhance the industrial applications of this cherry’s pulp as a potential functional food ingredient. Foam-mat drying was used to produce cherry powder from cherry pulp. The convective drying process was performed at different temperatures (50, 60, 70, and 80°C) to study the effect of drying temperature on the physical properties, flow properties, microstructure, (poly)phenol content, antioxidant properties, and bioaccessibility of foam-dried cherry pulp, in comparison to freeze-dried sample. Different drying temperatures did not affect color properties. The highest gloss was determined at high temperatures (70–80°C). According to the Carr index, the fluidity increased between 18 and 22% as the temperature increased. The total phenolic content was higher at elevated temperatures (70–80°C), yet the anthocyanin content was the highest at 60°C. The flavonoid content was not affected by different drying temperatures, as well as compared to lyophilized samples. The antioxidant activity was higher in samples dried at elevated temperatures, with no significant difference in comparison to lyophilized samples. The bioaccessibility experiment showed that the lyophilized samples had significantly greater bioaccessibility in comparison to the convective dried samples, yet further investigation is required to understand the differences in bioaccessibility and bioavailability of individual polyphenols. Overall, foam-mat drying using a convective drying system could be an economic choice to preserve acceptable amounts of phenolics and antioxidants.
Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor
Authors: Diallo Mickael , Pimenta Constança , Murtinheira Fernanda , Martins-Alves Daniela , Pinto Francisco R. , da Costa André Abrantes , Letra-Vilela Ricardo , Martin Vanesa , Rodriguez Carmen , Rodrigues Mário S. , Herrera Federico 
Published: December 2023

AbstractSTAT3 is a pleiotropic transcription factor overactivated in 70% of solid tumours. We have recently reported that inactivating mutations on residues susceptible to post-translational modifications (PTMs) in only one of the monomers (i.e. asymmetric) caused changes in the cellular distribution of STAT3 homodimers. Here, we used more controlled experimental conditions, i.e. without the interference of endogenous STAT3 (STAT3-/- HeLa cells) and in the presence of a defined cytokine stimulus (Leukemia Inhibitory Factor, LIF), to provide further evidence that asymmetric PTMs affect the nuclear translocation of STAT3 homodimers. Time-lapse microscopy for 20 min after LIF stimulation showed that S727 dephosphorylation (S727A) and K685 inactivation (K685R) slightly enhanced the nuclear translocation of STAT3 homodimers, while K49 inactivation (K49R) delayed STAT3 nuclear translocation. Our findings suggest that asymmetrically modified STAT3 homodimers could be a new level of STAT3 regulation and, therefore, a potential target for cancer therapy.
Quality Criteria for Studies Assessing the Acute Effects of Heading: Results from a UEFA Expert Panel
Authors: Peek Kerry , Franchi Martino , Lemmink Koen , Balsom Paul , Meyer Tim 
Published: December 2023

AbstractThere is increasing concern regarding the effects of heading in football on brain health including cognitive, behavioural and neuromotor function, with research suggesting an association between repeated ball-head impacts and neurodegenerative disease. While longitudinal studies to determine the long-term consequences of heading are challenging, there have been short-term ‘acute’ studies conducted, with some studies lacking appropriate methodology to ensure valid results. The Union of European Football Associations (UEFA) established a panel of experts to determine methodological recommendations for the conduct of studies that explore the acute effects of heading (defined as a single session of heading conducted either in a laboratory setting or following match play or a training session). The aim of this panel was to create quality criteria for acute heading studies that will form part of the eligibility assessment when applying for UEFA research funding (although the criteria can be applied to the conduct of acute heading research more widely). This process was deemed necessary to counter studies with poor methodological quality that used heading trials that did not accurately represent player exposure to ball-head impacts through football practice and match play (such as small sample sizes, unrealistically high heading exposure, and a lack of consideration of confounding variables). The panel identified core design decisions that authors should consider when designing and conducting acute heading research, with key methodological requirements for each domain pertaining to participants, heading trials, confounding variables, statistics and dependent/target variables and their measurement. After two rounds of reviews, the final list of quality criteria was agreed by the panel and will be applied to the next round of UEFA grant applications.
Fear of Relationship Commitment and Singlehood
Authors: Apostolou Menelaos , Tekeş Burcu 
Published: December 2023

AbstractNot having an intimate partner is a common state in contemporary post-industrial societies. One reason that individuals report for being single is their fear of relationship commitment. The objective of the current research was to investigate the factors that are associated with the fear of relationship commitment and how this fear is associated with singlehood. In a sample of 453 Turkish-speaking participants, we found that lower levels of agreeableness, openness, mating performance, and relationship quality were associated with a higher fear of relationship commitment. Moreover, a higher fear of relationship commitment was linked to a greater likelihood of being single compared to being in an intimate relationship. Additionally, we found that lower levels of self-esteem, extraversion, and openness were associated with reduced mating performance, which, in turn, was associated with a higher fear of relationship commitment and a higher probability of being single compared to being in an intimate relationship.
XRD-Analysis of the Relation of Stacking Fault Formation and the TRIP-Effect in ADI
Authors: Stieler Felix , Tonn Babette 
Published: December 2023

AbstractThe mechanical properties of ausferritic ductile iron are strongly influenced by the ability of the austenite to undergo martensite formation. Strain-induced martensite formation occurring under the right circumstances results in transformation induced plasticity (TRIP) that improves ductility and strength. TRIP has been shown to depend on the austenite’s stacking fault energy (SFE), which describes the crystals micromechanical behaviour. In austenitic FeMnAlSi-TRIP steels, TRIP as a reaction to mechanical load only occurs for SFE <20 mJ/m2. For carbon-stabilised austenite as in ADI, the relationship between stacking faults, mechanical properties and martensitic transformation has not yet been established. To investigate the TRIP-effect in ADI, unalloyed ADI with 3.43 wt% C, 2.52 wt% Si and 0.21 wt% Mn was ausferritised and subjected to tensile tests at temperatures between −180 °C and 200 °C. The amount of martensite produced by thermal and mechanical activation, crystalline microstrain and stacking fault density were measured on deformed and undeformed regions of the specimen by XRD and the resulting SFE calculated. Between −70 and 20 °C, the elongation at fracture exceeded 10 % compared to below 2 % in the temperature range of −130 to −180 °C. At temperatures above 80 °C, elongation at fracture gradually decreased to 4.5 % at 200 °C. High sample ductility was associated with lower SFEs as low as 35 mJ/m2, indicating a correlation of stacking fault formation and strain-induced martensite formation in ADI.
Predictors of the clinical severity of T1DM presentation at diagnosis in children and adolescents with type 1 diabetes mellitus (T1DM)
Authors: Karavanaki Kyriaki , Korona Anastasia , Karanasios Spyridon , Kossiva Lydia 
Published: December 2023

Abstract
Purpose
We aimed to assess factors associated with the presence and severity of ketoacidosis (DKA) at pediatric type 1 diabetes (T1DM) diagnosis, in relation to pancreatic, associated and familial autoimmunity.

Methods
Antibodies against pancreatic beta-cells, organ specific autoantibodies (thyroid, celiac, and parietal) and family history of autoimmunity were retrospectively evaluated in 116 T1DM patients aged 11.9 ± 4.6 (mean ± SD) years, with disease duration 7.62 ± 3.67 years (mean ± SD).

Results
Most patients (67.2%) presented with DKA at diagnosis. Younger children (< 2 years) had tenfold risk of DKA, compared to older children (12.1–15 years) (OR = 10.8, 95% CI: 1.0–116.9, P = 0.05). Fasting c-peptide levels were lower in the DKA group (OR = 0.26, 95% CI = 0.07–0.89, P = 0.033). The number of anti-pancreatic antibodies at disease onset did not show any significant correlations with the presence (p = 0.889) or severity of DKA (p = 0.863). All patients with multiple autoimmunity (> 2 autoimmune diseases plus T1DM) presented with DKA. Familial autoimmunity acted protectively against DKA manifestation (OR = 0.40, 95% CI = 0.16–1.0, P = 0.051).

Conclusions
Among newly diagnosed T1DM patients, 67.2% presented with DKA. Younger age, lower c-peptide and the presence of associated autoimmunity were predictive factors of the presence and severity of DKA at diagnosis. High degree of suspicion, due to family history, may prevent DKA development and severity.
The potentiality of nature to tug at our heartstrings: an exploratory inquiry into supportive affordances for emotion-focused family therapy in the outdoors
Authors: Fernee Carina Ribe , Wahlgren Sophia Louise Hjorth , Trangsrud Lise Katrine Jepsen 
Published: December 2023

AbstractA wealth of studies demonstrate the associations between nature contact and well-being, and gradually, nature-based solutions are becoming more widespread in mental health care and recovery. While emotion-focused therapies generally show promising results, evidence of nature-based family therapy is still scarce. In a forthcoming clinical trial at Sørlandet hospital in Southern Norway, we will compare indoor and outdoor provision of emotion-focused multi-family therapy. The foundation of emotion-focused therapeutic work with families is a deep belief in the healing powers of families, where resources within the “ecosystem” of a given family can be reactivated and nudged towards establishing a greater sense of harmony and connectedness over time. According to a Gibsonian understanding of affordances, humans respond to possibilities and limitations within an environment, where affordances in the context of this article arise from a systemic interplay between nature, participating families and facilitators. In this exploratory inquiry, we are particularly interested in the myriad ways nature may influence four core principles in emotion-focused therapy, including (a) emotion awareness, (b) emotion regulation, (c) reflection on emotion, and (d) emotion transformation. In this perspective article, we propose hypotheses and working metaphors in relation to everything from emotions’ multiple purposes to the delineation of facilitators’ accepting, empathic and curious stance. First and foremost, we attempt to generate a preliminary account of nature’s potentiality to tug at our heartstrings and offer a supportive environment for the novel provision of emotion-focused family therapy in the outdoors.
Frame plurality and ‘or/rationality’: a dialogic approach to the behavioral state
Authors: Schmidt Ruth , Stenger Katelyn 
Published: December 2023

Abstract
Consequentialist theories of the behavioral state are largely grounded in satisfying self-interested preferences through policies that employ choice architecture and related strategies to encourage rational decision-making. Even when allowing for free choice, however, this stance tends to be characterized by a paternalistic ‘view from nowhere’ that may not fully accommodate a plurality of values. Alternative approaches such as contractarianism position policy in the context of marketplace exchange, bolstered by shared beliefs in the legitimacy of social institutions. Yet this view may not sufficiently consider issues of asymmetric access, or ideological frames that do not see these institutions as legitimate. To address these deficits, we propose the value of a dialogical approach to behavioral public policy that facilitates collaborative engagement and behavioral justice to redress asymmetries and inequities through a more discursive approach, which builds on practices employed by design for public policy. In so doing, this political theory suggests an actionable counterpoint to paternalistic and competition-based conceptions of the State to address frame plurality and increase the potential for system equity.
Headache Education in Canadian Medical Schools
Authors: Guay Meagan , Lagman-Bartolome Ana Marissa , Lay Christine 
Published: December 2023

ABSTRACTThis study aims to gain a better understanding of the current scope of headache education received in Canadian medical schools. The Women’s College Hospital Centre for Headache at the University of Toronto, Canada, distributed a questionnaire to administrators and physicians involved in medical student education at Canadian medical schools and gathered information surrounding headache education. Overall, the degree of headache education varied between schools in regard to the hours of training that occurred and year the training took place. This survey provides an initial insight into the current standards of headache-specific education in Canadian medical schools.
A Prospective Post-Marketing Observational Study of Brivaracetam in People With Focal Epilepsy
Authors: Yanes Rayan , Briard Joel Neves , Nguyen Tang-Duc Jeremy , Sultanem Maya , Nguyen Dang Khoa , Gibbs Steve , Ikeda Kristin , Jirsch Jeffrey , Josephson Colin , Boisse Lomax Lysa , Cloutier Véronique , Keezer Mark 
Published: December 2023

ABSTRACT:We evaluated the effectiveness and tolerability of brivaracetam (BRV), an adjunctive antiseizure medication, as a treatment for focal epilepsy in adults. In this prospective study, we enrolled 51 participants from 3 sites across Canada. At 6 months, 68% (26/38) of participants were still taking BRV, among whom 35% (8/23) attained seizure freedom and 48% (11/23) saw their seizure frequency reduced by over 50%. We did not measure any significant change in irritability, quality of life, depression, and anxiety while treated with BRV. Our findings suggest BRV is effective in reducing seizure frequency among adults with focal epilepsy.
Retrospective Analysis of Canadian Adults with Tuberous Sclerosis Complex
Authors: Pal Dominique , Forster Nicole , Madan Monika , Whitney Robyn , Farncombe Kirsten M. , Kim Raymond H. 
Published: December 2023

ABSTRACT:Background:Our study goal was to characterize the relative frequencies of molecular and phenotypic traits of tuberous sclerosis complex (TSC) in a Canadian adult population. Previous studies have sought to identify TSC-related genotypic and phenotypic trends in pediatric cohorts, but little is known about clinical manifestations and severity when it presents in adults.Methods:We conducted a retrospective chart review of adult patients seen at the TSC clinic at the University Health Network genetics clinics (Toronto, Ontario) to compare trends in the relative frequency of TSC manifestations with genotype.Results:Fifty-one patients were eligible for this study. Eight patients had a pathogenic/likely pathogenic variant in the tuberous sclerosis complex 1 (TSC1) gene, 18 had a tuberous sclerosis complex 2 (TSC2) pathogenic/likely pathogenic variant, 6 patients had multiple variants identified in TSC1/TSC2 or TSC2/PKD1, 11 had no mutation identified (NMI) and 8 had no genetic testing done. Patients with a pathogenic/likely pathogenic variant in TSC2 presented with an increased involvement of multiple systems and a higher frequency of TSC-related manifestations relative to the other mutation groups.Conclusion:Previous studies comparing the wide phenotypic variability with TSC genotype have mainly comprised pediatric cohorts. With a focus on adults, we found trends to be similar across previous literature. An informed multidisciplinary approach should be taken to ensure proper surveillance and management of adults with TSC until a correlation between genotype and phenotype, especially past infancy, is better understood.