bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioassays for the evaluation of the attractiveness of attractive targeted sugar bait (ATSB) against Anopheles mosquitoes in controlled semi-field systems
Authors: Tenywa Frank S. C. , Kibondo Ummi A. , Entwistle Julian , Dogan Osward , Haruna Mapipi , Phisoo Restuta P. , Moore Jason , Machange Jane J. , Makame Haji , Tripet Frederic , Müller Pie , Mondy Mathias , Nimmo Derric , Stevenson Jennifer C. , Moore Sarah J. 
Published: February 2025

Abstract

Background
Sugar feeding is an essential aspect of mosquito biology that may be exploited for mosquito control by adding insecticides to sugar attractants, so-called ‘attractive targeted sugar baits’ (ATSBs). To optimize their effectiveness, ATSB products need to be maximally attractive at both short and long range and induce high levels of feeding. This study aimed to assess the attractiveness and feeding success of Anopheles mosquitoes exposed to attractive sugar baits (ASBs).

Method
Experiments were conducted in 2 × 5 × 2-m cages constructed within the semi-field systems (SFS) at Ifakara Health Institute, Bagamoyo, Tanzania. Male and female Anopheles gambiae s.s. and An. funestus s.s. mosquitoes were exposed to either 20% sucrose or different ASB station prototypes produced by Westham Co. in either (1) no-choice experiments or (2) choice experiments. Mosquitoes were exposed overnight and assessed for intrinsic or relative olfactory attraction using fluorescent powder markers dusted over the ASB stations and 20% sucrose and for feeding using uranine incorporated within the bait station and food dye in 20% sucrose controls.

Results
Both male and female An. gambiae and An. funestus mosquitoes were attracted to the ASBs, with no significant difference between the sexes for each of the experiments conducted. Older mosquitoes (3–5 days) were more attracted to the ASBs (OR = 8.3, [95% CI 6.6–10.5] P < 0.001) than younger mosquitoes (0–1 day). Similarly, older mosquitoes responded more to 20% sucrose (OR = 4.6, [3.7–5.8], P < 0.001) than newly emerged Anopheles. Of the four prototypes tested, the latest iteration, ASB prototype v1.2.1, showed the highest intrinsic attraction of both Anopheles species, attracting 91.2% [95% CI 87.9–94.5%]. Relative to ATSB v1.1.1, the latest prototype, v.1.2.1, had higher attraction (OR = 1.19 [95% CI 1.07–1.33], P < 0.001) and higher feeding success (OR = 1.71 [95% CI 1.33–2.18], P < 0.001).

Conclusions
Data from these experiments support using ASBs v1.2.1, deployed in large-scale epidemiological trials, as it is the most attractive and shows the highest feeding success of the Westham prototypes tested. The findings indicate that future bioassays to evaluate ATSBs should use mosquitoes of both sexes, aged 3–5 days, include multiple species in the same cage or chamber, and utilize both non-choice and choice tests with a standard comparator.
Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate
Authors: Wang Shuang , Ma Ruishuang , Gao Chong , Tian Yu-Nong , Hu Rong-Gui , Zhang Han , Li Lan , Li Yue 
Published: February 2025

Abstract

Background
Tuberous sclerosis complex is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, affecting multiple systems. These genes produce proteins that regulate mTORC1 activity, essential for cell function and metabolism. While mTOR inhibitors have advanced treatment, maintaining long-term therapeutic success is still challenging. For over 20 years, significant progress has linked TSC1 or TSC2 gene mutations in stem cells to tuberous sclerosis complex symptoms.

Methods
A comprehensive review was conducted using databases like Web of Science, Google Scholar, PubMed, and Science Direct, with search terms such as “tuberous sclerosis complex,” “TSC1,” “TSC2,” “stem cell,” “proliferation,” and “differentiation.” Relevant literature was thoroughly analyzed and summarized to present an updated analysis of the TSC1-TSC2 complex’s role in stem cell fate determination and its implications for tuberous sclerosis complex.

Results
The TSC1-TSC2 complex plays a crucial role in various stem cells, such as neural, germline, nephron progenitor, intestinal, hematopoietic, and mesenchymal stem/stromal cells, primarily through the mTOR signaling pathway.

Conclusions
This review aims shed light on the role of the TSC1-TSC2 complex in stem cell fate, its impact on health and disease, and potential new treatments for tuberous sclerosis complex.

Graphical abstract
MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis
Authors: Bai Huifang , Dang Qianqian , Chen Guoliang , Xie Lingfeng , Wang Saining , Jiang Ning , Wu Xiaoxia , Zhang Shuyan , Wang Xuelin 
Published: February 2025

Abstract

Trichinella spiralis (T. spiralis) has been reported to induce inflammation, which can cause immune system dysregulation. Myeloid differentiation primary response gene 88 (MyD88) is implicated in inflammation signalling pathways. TJ-M2010-5 is a novel MyD88 inhibitor with remarkable protective effects against several diseases. However, the precise mechanism of TJ-M2010-5’s involvement in spleen impairment and inflammation in the early infection of T. spiralis has yet to be fully elucidated. This study analysed histological, inflammation, and macrophage polarisation of the early T. spiralis-infected mice treated with TJ-M2010-5. MyD88 promoter methylation results showed that the methylation levels in the 5 d group were lower compared to the control group (P < 0.05). Furthermore, the methylation led to an imbalance in anti-inflammatory regulation in the infected mice. After TJ-M2010-5 treatment, spleen impairment was reduced. Sequencing analysis showed that TJ-M2010-5 significantly up-regulated 9 and down-regulated 10 miRNAs compared with the 5 d group. A dual-luciferase reporter assay further revealed that miR-136-5p is involved in the TJ-M2010-5 treatment by targeting AKT3. In RAW264.7 cells, TJ-M2010-5 pre-treatment significantly reversed the M1 polarisation and inhibited nitric oxide (NO) production. LC–MS/MS results showed TJ-M2010-5 was hepatosplenic-targeted. In conclusion, the study demonstrates that TJ-M2010-5 could effectively alleviate spleen impairment and reduce inflammation in mice infected with T. spiralis in its early stages by blocking the activation of PI3K/miR-136-5p/AKT3.
Perspectives of substance use disorder counselors on the benefits and drawbacks of medications for opioid use disorder
Authors: Cardamone Nicholas C. , Stewart Rebecca E. , Kampman Kyle M. , Marcus Steven C. 
Published: February 2025

Abstract

Background
Medications for opioid use disorder (MOUD) are among the best tools available to combat the opioid epidemic. Yet, use of MOUD among people with opioid use disorder (OUD) remains low. Interventions to increase MOUD access in the United States have largely focused on improving organizational capacity and addressing funding barriers, yet stigma toward MOUD may inhibit uptake even where MOUD is readily available. Non-prescribing substance use disorder (SUD) treatment professionals (e.g. counselors) likely have considerable influence on a client’s choice to initiate and adhere to MOUD, but beliefs that counselors convey about MOUD in interaction with clients are understudied. The current study explores what advantages and disadvantages that counselors communicate about buprenorphine, methadone, and naltrexone.

Methods
From June to December 2021, we surveyed counselors from publicly-funded SUD treatment agencies under a municipality-wide mandate to offer MOUD to all clients with OUD. Counselors were asked to describe, in a free-response format, the most important advantages and disadvantages to communicate to their clients about taking buprenorphine, methadone, and naltrexone. Counselor responses were coded for one or more advantage and disadvantage.

Results
A total of 271 SUD counselors from 29 agencies in the Philadelphia Metropolitan Area completed the survey, generating 1,995 advantages and disadvantages across three types of MOUD. The most frequently reported advantage across all three types of MOUD was their ability to reduce cravings and illicit drug use. The most frequently reported disadvantage related to the potential for some types of MOUD to develop long-term medication dependence.

Conclusions
As the availability and variety of MOUD treatment options continue to expand, it is important that SUD counselors are equipped with evidence-based recommendations for OUD care. We identified misalignments with the MOUD-prescribing evidence base and stigmatizing language toward MOUD within counselors’ responses, highlighting the potential to refine training materials for MOUD and mitigate stigmatizing beliefs.
Experimental Investigation of Inclusion of Various Nanocarbon Black Concentrations on Mechanical Characteristics of Oil-Well Cement Slurries in High-Pressure High-Temperature Conditions
Authors: Ebied Ahmed , Fakher Sherif , Kayed Hatem 
Published: February 2025

Abstract
This study investigates the impact of adding nanocarbon black (NCB) to wellbore cement under high-pressure, high-temperature (HPHT) conditions to enhance its properties for long-term zonal isolation. Four cementitious slurries were prepared in the laboratory using the wet-mixing method, following the American Petroleum Institute standards (API 10B-2 and API 10A). NCB was incorporated as a reinforced nanomaterial in cementitious composites at varying concentrations of 0.05%, 0.1%, and 0.2% by weight of cement (BWOC) into the slurry mix fluid following a specific mixing sequence before the addition of Class-G wellbore Portland cement, which is manufactured via the dry process and commonly used in the oil and gas industry. The study evaluated parameters, such as density, rheology, free fluid (FF), fluid loss (FL), thickening time (TT), compressive strength (CS), tensile strength (TS), porosity, and permeability, following API standards. The results demonstrated that NCB additions slightly increased slurry density and significantly improved rheological properties, with low yield stress at bottomhole circulating temperatures. NCB concentrations of 0.05% and 0.1% reduced free fluid, fluid loss, and thickening time while enhancing the cement sheath's compressive and tensile strength, simultaneously reducing its porosity and permeability. Moreover, the improved early compressive strength development indicated accelerated cement hydration reactions due to incorporating NCB. The study found that 0.1% NCB was the optimal concentration, enhancing mechanical properties and operational efficiency by reducing wait-on-cement time and costs while improving wellbore integrity. However, higher NCB concentrations required careful dispersion to prevent nanoparticle agglomeration. Overall, NCB significantly enhanced cement sheath characteristics under HPHT conditions.
Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases
Authors: Huang Qiaolin , Zhu Xiaojian , Zhang Yicheng 
Published: February 2025

Abstract
Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. In this review, we highlight recent advances in the engineering of T cells in non-oncology areas, including autoimmune and inflammatory diseases, infections, fibrosis, hemophilia, and aging. Chimeric antigen receptor immunotherapy has shown good outcomes in non-oncology areas, but many challenges remain in improving its safety and efficacy and and expanding its application to the treatment of non-oncological diseases.
Sol–gel synthesis of silicon oxide (SiO2) nanoparticles: exploring gas sensing and photocatalytic applications
Authors: Sonawane Laxmi D. , Mandawade Abhinay S. , Gite Anil B. , Shinde Sarika D. , Patil Ganesh E. , Nikam Latesh K. , Goswami Vishal H. , Bhise Ramesh B. , Sarawade Pradip B. , Shinde Mahendra S. 
Published: February 2025

Abstract
In this research, silicon oxide (SiO2) nanoparticles (NPs) were synthesized using the sol–gel method. The synthesized materials were characterized through various techniques. Fourier transform infrared spectroscopy (FTIR) revealed the absorption band corresponding to Si–O–Si bonds. Ultraviolet–visible (UV–Vis) spectroscopy analysis indicated a band gap energy of 5 eV. X-ray diffraction (XRD) analysis displayed a broad peak, confirming the amorphous nature of the material. Field emission scanning electron microscopy (FESEM) further demonstrated a spherical morphology of the SiO2 NPs. The photocatalytic degradation of MB dye using SiO2 NPs has been examined, revealing promising and improved degradation properties. Even a small amount of SiO2 NPs achieved around 69.20% degradation of MB within 240 min, with the rate constant for the material being 0.001 min−1. The gas sensing properties of the SiO2 NPs were tested on domestic gas sensor units for different gases, including ethanol, methanol, CO2, LPG, H2S, NH3, O2, and Cl2, at temperatures ranging from room temperature to 300 °C. Among these materials, SiO₂ NPs displayed the strongest response to H₂S gas, showing outstanding gas-sensing performance at a concentration of 100 ppm. The response time was 18 S, with a quick recovery time of approximately 22 S.

Graphical Abstract
Beyond minutiae: inferring missing details from global structure in fingerprints
Authors: Searston Rachel A. , Thompson Matthew B. , Robson Samuel G. , Tangen Jason M. 
Published: February 2025

Abstract
Visual inference involves using prior knowledge and contextual cues to make educated guesses about incomplete or ambiguous information. This study explores the role of visual inference as a function of expertise in the context of fingerprint examination, where professional examiners need to determine whether two fingerprints were left by the same person, or not, often based on limited or impoverished visual information. We compare expert and novice performance on two tasks: inferring the missing details of a print at an artificial blank spot (Experiment 1) and identifying the missing surrounds of a print given only a small fragment of visual detail (Experiment 2). We hypothesized that experts would demonstrate superior performance by leveraging their extensive experience with global fingerprint patterns. Consistent with our predictions, we found that while both experts and novices performed above chance, experts consistently outperformed novices. These findings suggest that expertise in fingerprint examination involves a heightened sensitivity to gist, or global image properties within a print, enabling experts to make more accurate inferences about missing details. These results align with prior research on perceptual expertise in other expert domains, such as radiology, and extend our understanding of scene and face recognition to fingerprint examination. Our findings show that expertise emerges from an ability to combine local and global visual information—experts skillfully process both the fine details and overall patterns in fingerprints. This research provides insight into how perceptual expertise supports accurate visual discrimination in a high-stakes, real-world task with broader implications for theoretical models of visual cognition.
Abdominal pseudocyst: a rare complication of ventriculoperitoneal shunt
Authors: Al-Mahrouqi Omar , Al-Saadi Tariq 
Published: February 2025

Abstract
Like any other surgical intervention, ventriculoperitoneal shunt (VPS) insertion is associated with multiple complications including bleeding, shunt infection, and shunt malfunction. Additionally, other complications involve the gastrointestinal tract, such as CSF pseudocyst or abdomen pseudocyst (APC) formation, have also been reported. The APC inhibits cerebrospinal fluid (CSF) absorption and causes shunt malfunction. Differential diagnosis might be difficult since APC can mimic other cystic abdominal diseases. This article aims to provide an updated review that summarize the most relevant findings available in the literature. This review can help clinicians in better understanding the clinical characteristics of this complication in order to develop a comprehensive approach that is associated with a lower incidence and recurrence rate of APC. Accurate history taking, precise clinical examination of signs and symptoms, abdominal imaging, and a high index of suspicion are key components of an APC diagnosis. Therefore, understanding predisposing factors and clinical features of such distinctive complication is essential for the adequate management of patients. Abdominal pseudocyst formation at the distal end of VPS can result in both features of shunt malfunction and abdominal signs and symptoms. Post-VPS APC, whenever suspected, should be assessed appropriately by imaging. The treatment of APC ranges from shunt removal and external drainage to various forms of shunt repositioning or conversion, and treatment decisions often depend on individual patient characteristics and surgeon preference.
“Spontaneous epidural hematoma in a pediatric patient following pansinusitis: a case report and review of the literature”
Authors: Nazarpour Shahin , Qoorchi Moheb Seraj Farid , Sharifzadeh Khavari Seyed Morteza , Seadghat Mehran , Abouei Mehrizi Mohammad Ali 
Published: February 2025

Abstract

Background
Spontaneous epidural hematoma commonly occurs in patients who have coagulopathy, vascular tumors, and vascular malformations. The association between this entity and maxillofacial infection is rare.

Case Presentation
A 17-year-old male patient presented to our emergency with a decreased level of consciousness. The patient had a history of nasal discharge and fever for about four days. The brain Computed tomography scan revealed a hematoma that was treated with craniotomy. The hematoma culture was positive for staphylococcus aureus, so antibiotic therapy was started for the patient and continued for six weeks. All the symptoms were fully recovered and the patient was discharged without any neurological deficits. Although spontaneous epidural hematoma following craniofacial infection is rare, prompt imaging and hematoma evacuation have been found with higher rates of favorable outcomes and Markley decreased mortality.

Conclusion
Distinguishing between hematoma and cerebral abscess is slightly difficult. However, consideration of surgery facilitates reaching a reliable diagnosis and treatment.
Detection to false data for smart grid
Authors: Zheng Jian , Ren Shumiao , Zhang Jingyue , Kui Yu , Li Jingyi , Jiang Qin , Wang Shiyan 
Published: February 2025

Abstract
False data injection attack in smart grid might does not launch interference and attack behaviors, so that this attack is difficult found. To address this, this paper proposed a conformal neural network detection method being sensitive to false data. Firstly, using the conformity scores calculated by the mathematical probability to identify the false data. Then, the neural network learns a boundary separating false data and normal data on the conformal region yielded by the conformity scores. Finally, experiments on simulated and real datasets indicate that the proposed method obtains 0.9738 detected accuracy, and the sensitivity to false data reaches 0.9387, defeating against the competitors, moreover, the proposed method does not exhibit exponential detection time as data volume augments. We demonstrate that evaluating the consistency between the data does not rely on data distributions and the operation status in this real-time system like smart grids, since conformity scores can calculate the mathematical probability following the same data distribution. The boundaries learned from conformal regions are independent of data distribution and the information of operation status in smart grids. This evaluation manner of data consistency and that of boundary learning are equally applicable to the identification and separation of those false data injected into other real-time systems.
Case report: a rare case of hereditary colorectal cancer and brain tumor with café au lait spots in a child: constitutional mismatch repair deficiency (CMMRD) syndrome
Authors: Khurshid Zubair , Shaikh Mishraz , Elkadi Tarek Talaat Harb 
Published: February 2025

Abstract

Background
Colorectal carcinoma (CRC) is rarely seen in the pediatric population. Hereditary cancers due to mismatch repair deficiency cause colorectal, brain, hematological malignancies, and other tumors in early childhood.

Case presentation
We present an 11-year-old boy who presented with colorectal cancer and brain tumor due to constitutional mismatch repair deficiency syndrome with a family history of sibling deaths due to brain tumors.

Conclusions
Hereditary cancers arising due to mismatch repair gene mutations cause early colorectal and brain cancers in children. The members of such families should be genetically screened for any mutations.
Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study
Authors: Muneeha Shaba , Chaudhary Raushan Kumar , Shetty Vijith Vittal , Patil Soumya , Mateti Uday Venkat 
Published: February 2025

Abstract

Background
Cervical cancer is the 4th most prevalent cancer among females globally. In India, approximately 123,907 women are diagnosed with cervical cancer every year, leading to 77,348 deaths annually. However, Indian healthcare system lacks the sufficient information regarding the factors influencing survival and mortality among cervical cancer patients at regional levels. Thus, we aimed to identify the predictors associated with survival outcomes and mortality rates among cervical cancer.

Methods
A retrospective cohort study was conducted over 8 months at a tertiary care hospital where 10-year (January 2013–December 2022) data of cervical cancer patients were analyzed from medical record department (MRD). Telephonic interviews were carried out with patients or patient parties to know the survival status of patients. The data was analyzed using descriptive statistics, Kaplan–Meier curve, log-rank test and Cox regression.

Results
Out of 330 cervical cancer patients, majority (64.24%) were > 50 years of age followed by 35.76% were < 50 years. Most of the patients had abnormal body mass index (BMI) (46.96%), postmenopausal stage (75.76%), stage II cancer (43.03%), histologically poorly differentiated grade (47.88%) and squamous cell carcinoma (87.88%), with radiation plus chemotherapy being popular treatment choice (48.79%) and with the overall mean age of 56 years. Age, BMI, menopause, stage of cancer, histological grades and types of treatment were found to be significant predictors (p < 0.05) of survival among cervical cancer patients. Using cox regression analysis, advanced age (age > 50 years: hazard ratio (HR): 1.82), underweight (BMI < 18.5: HR:1), postmenopause (HR:1), advanced stage of cervical cancer (Stage I, Stage II, Stage III, Stage IV: HR:1, HR:2.78, HR:10.08, HR:20.81), poorly differentiated cervical cancer (HR:1.70), radiation therapy (HR:4.86), chemotherapy (HR:6.55) or chemoradiation therapy (HR:3.31) and surgery plus chemotherapy (HR: 4.55) were identified to be significant predictors of mortality among cervical cancer patients.

Conclusion
We conclude that the 5- and 10-year survival rates for cervical cancer patients were found to be 51.2% and 42.9%, respectively. Advanced age, underweight, postmenopausal status, advanced cancer stage, poor cancer cell differentiation and chemotherapy-based treatment were significant predictor of mortality and vice-versa for survival which might guide clinicians and policymakers in making informed clinical decisions to combat cervical cancer.