bluuebunny/crossref_metadata_2025_split huggingface dataset:
Literasi Keuangan, Risk Tolerance dan Overconfidence Terhadap Keputusan Investasi pada Pekerja di Kawasan Industri Cikarang
Authors: Listiani Efi , Soleha Erin 
Published: January 2024

This study aims to analyze the effect of financial literacy, risk tolerance and overconfidence on investment decisions for workers in the Cikarang Industrial Area. The research method used is quantitative method with a total sample of 100 respondents which is determined by using non-probability sampling technique. The results of this study show that the t-statistic value for the financial literacy variable is 3.089 > 1.96 and the p-value is 0.002 <0.05. Overconfidence has a t-statistic value of 4.339 > 1.96 and a p-value of 0.000 <0.05 and the risk tolerance variable has a t-statistic value of 0.081 <1.96 and a p-value of 0.935 > 0.05. In conclusion, financial literacy and overconfidence have a significant positive effect on workers' investment decisions in the Cikarang Industrial Area. Meanwhile, risk tolerance has no effect on workers' investment decisions in the Cikarang Industrial Area. The most dominant variable affecting investment decisions is overconfidence so that the higher the level of self-confidence a person will make the decision to invest will increase.
Keywords: Overconfidence, Investment Decision, Literacy, Risk Tolerance
Optimalisasi Badan Usaha Milik Desa (BUMDes) Melalui Akuntabilitas dan Alokasi Dana Desa di Kecamatan Sumberpucung, Kabupaten Malang
Authors: Hernita Larasati Pingkan Cahya , Muslimin Muslimin 
Published: January 2024

This research aims to determine the influence of effectiveness, accountability and allocation of village funds on the optimization of Village-Owned Enterprises (BUMDes) in Sumberpucung District, Malang Regency. This research method uses quantitative methods using primary data. The data collection method uses a questionnaire distributed to respondents according to the criteria. The research results show that accountability influences the optimization of BUMDes, and the allocation of village funds influences the optimization of BUMDes.
Keywords: Accountability, BUMDes, Village Funds, Effectiveness
Analisis Hubungan Komunikasi, Kepemimpinan dan Disiplin Kerja Terhadap Kepuasan Kerja Karyawan
Authors: Bara Muhammad Alfaridzi Batu , Purba Mas Intan , Pasarib Fitriyani , Mauliza T Ryan , Lubis Nurul Wardani 
Published: January 2024

This study aims to examine and analyze the effect of Promotion, Service Quality and Consumer Satisfaction on Gojek Consumer Loyalty (Case Study on Law Faculty Students at Prima University of Indonesia). The research method used is quantitative. Total population of 208 students and 68 employees as research samples. The sampling technique used is random sampling. The results showed that promotion partially had a positive and significant effect on Gojek Consumer Loyalty. Service Quality has a positive and significant effect on Gojek Consumer Loyalty. Consumer Satisfaction has a positive and significant effect on Gojek Consumer Loyalty. Promotion, Service Quality and Consumer Satisfaction have a positive and significant effect on Gojek Consumer Loyalty. In conclusion, promotion level, service quality and customer satisfaction have a role in customer loyalty.
Keywords: Customer Satisfaction Service Quality, Consumer Loyalty, Promotion
Dampak Pelatihan Kerja, Disiplin Kerja dan Motivasi Kerja Terhadap Kinerja Karyawan pada PTPN III Medan
Authors: Br Sinaga Minne Sotha Roma Ito , Novita Herlina , Marbun Rifaldi 
Published: January 2024

This research aims to determine the effect of Job Training (Variable X1), Discipline (X2), and Work Motivation (X3) on employee performance. The method used in this research is quantitative methods. The data collection techniques used by researchers in this research are through interviews, questionnaires and documentation. Data analysis techniques start from data preparation, data tabulation to the testing stage. The results of the research calculations of multiple linear regression analysis show that the coefficient of determination (R2) can be obtained from the variables. This research aims to determine the influence of Job Training (Variable X1), Discipline (X2), and Work Motivation (X3) which influence 79.3% (0.793) on employee performance (Y), the remaining 20.7% is influenced by other factors outside this research. Conclusion, Job Training (Variable X1), Discipline (X2), and Work Motivation (X3) influence employee performance.
Keywords: Work Discipline, Employee Performance, Motivation, Job Training
Implementasi Kebijakan Pendidikan
Authors: Pratama Dandy Putra , Hadi Saputra , Syaifuddin Muhammad 
Published: January 2024

Implementasi kebijakan pendidikan memiliki arah tujuan agar terealisasinya sistem pendidikan yang baik. Terwujudnya kebijakan pendidikan yang baik akan menjadikan suatu bangsa atau generasi menciptakan peradaban yang maju. Implementasi kebijakan pendidikan merupakan salah satu aktifitasi dalam proses kebijakan yang menentukan sebuah kebijakan bersentuhan dengan stakeholder pendidikan setara dapat diterima oleh masyarakat. Pemerintah memiliki kewenangan dalam mengatur formulasi atau rumusan terkait kebijakan yang akan diimplementasikan. Maka dari itu pemerintah diharapkan dapat mewujudkan kebijakan pendidikan yang menguntungkan banyak orang. Artikel ini membahas tmengenai implementasi kebijakan pendidikan. Metode yang digunakan dalam tulisan ini adalah library research atau penelitian kepustakaan. Penelitian ini dikategorikan sebagai penelitian deskriptif, karena pendekatan yang dilakukan adalah melalui pendekatan kualitatif. Tujuan dari penelitian ini adalah memperoleh informasi tentang implementasi kebijakan, factor yang mempengaruhinya, tujuan implementasi kebijakan serta strategi atau langkah dalam implementasi kebijakan. Hasil dari penelitian ini yaitu implementasi kebijakan pendidikan merupakan pelaksanaan dari hasil rumusan atau kebijakan yang di tetapkan oleh pemerintah terkait pelaksanaan pendidikan.

Kata kunci: Implementasi; kebijakan; pendidikan
AKTYWNOŚĆ FIZYCZNA W UJĘCIU TURYSTYKI I REKREACJI OSÓB STARSZYCH
Authors: CZARNECKI Dawid , TSYHANOVSKA Nataliia , SKALSKI Dariusz W. , PAVLYUK Yevgen 
Published: January 2024

Starzenie się ludności Europy i Polski jest prawdopodobnie najważniejszym wyzwaniem zdrowotnym i społeczno-politycznym nadchodzących lat. Przewiduje się, że w 2050 roku osoby w wieku 60–79 lat będą stanowić jedną czwartą całej ludności Unii Europejskiej. Starzenie się społeczeństwa to problem, który szczególnie dotyczy państw europejskich Ekonomiści i demografowie przewidują, że w XXI wieku Europa zmarginalizuje się, stanie się wymierającym kontynentem, gdzie miejsce dotychczasowej ludności zajmą emigranci. Przewiduje się, że populacja mieszkańców Europy, którzy stanowią ok. 10% ludności świata, za 50 lat zmniejszy się do 5%. Utrzymanie na odpowiednim poziomie stanu zdrowia, samodzielności i niezależności osób starszych staje się wielkim wyzwaniem. Jest to nie tylko wyzwanie dla zdrowia publicznego, ale również ogromny problem społeczno-ekonomiczny. Ewolucja cywilizacyjna i progres w medycynie przyczyniły się do wydłużenia życia człowieka. Nieznane kiedyś metody lecznictwa oraz nowoczesne środki farmaceutyczne zdecydowanie przedłużają zdolności osobnicze do zachowania sprawności fizycznej w zakresie układu krążenia, oddechowego i narządu ruchu. Aktywność fizyczna jest zatem ważnym czynnikiem kształtującym zdrowie, zdrowe nawyki, ale także wartościowe spędzanie czasu wolnego. Aktywność fizyczna to jeden z głównych składników zdrowego stylu życia. Istnieje powszechne przekonanie, że aktywność fizyczna jest jedną z ważniejszych kategorii warunkujących prawidłowe funkcjonowanie ludzkiego organizmu. Prowadzenie aktywnego stylu życia wiąże się bowiem z wieloma korzyściami. Korzyści płynących z udziału osób starszych w turystyce jest bardzo wiele. Żeby jednak zachęcić seniorów do podróżowania, niezbędne jest przygotowanie właściwej, a tym samym atrakcyjnej oferty usługowej dla tej grupy wiekowej. Koniecznym w tym celu jest wcześniejsze zdiagnozowanie ich oczekiwań w tym zakresie. W związku z powyższym za zasadne uznaje się rozpoznanie omawianego zjawiska i przeprowadzenie stosownych badań, a za cele opracowania przyjąć ukazanie preferencji i zachowań turystycznych osób starszych.
The Elongated Architectural Threshold: Healthful Placemaking within the Thickened Facade
Authors: Turchyn Samantha 
Published: January 2024

<p>Edges of architecture and the body define spatial relationships that influence the preservation and/or deterioration of human health. Proxemics during historical infectious diseases, as well as the recent realities of the COVID-19 experience, have demonstrated the physical health benefits of an elongated threshold. However, the methods used to create the extension of space necessary for proper physical distancing has also revealed the inefficient conditions of spatial and structural thinness of contemporary urban storefronts. Thin architectural entrances do not provide the interstitial depths necessary for accommodating secure distances and interactions between bodies in public settings. The phenomenon of physical objects being tactically reappropriated as appendages of typical streetscape façades materializes the need for thickening the entry sequence. This thesis aims to investigate how the elongated threshold can develop an entrance system that achieves dynamic opportunities of accessibility and provides corporal and social healthfulness during pandemic and post-pandemic periods. </p>
فاعلـية برنـامج تعليـمي قـائم على أنـموذج وودز فـي تعـلم مـهارة التـهديف لـكرة القـدم لطـلاب المـدرسة التـخصصية
Authors: Teacher . Dr. Enas Abdel Fattah Al-Khair  , Louay Mishaan Shandoukh  
Published: January 2024

يهدف البحث الى اعداد بـرنامج تعليـمي قائم على أنـموذج وودز وبـما يتلاءم مع مستوى عينة البحث, و التعرف على فاعلية برنامج تعليمي قائم على أنموذج وودز في تعلم مهارة التهديف لكرة القدم لطلاب المدرسة التخصصية , والأفضلية بين المجموعتين , تم اعتماد منهج البحث التجريبي لمجموعتين متساويتين , وكانت العينة لاعبي خماسي كرة القدم من طلاب المرحلة المتوسطة للمدرسة التخصصية (مديرية تربية محافظة الأنبار- قسم النشاط الرياضي المدرسي) للسنة الدراسية 2021-2022 تم اختيارهم عمديا, والبالغ عددهم (40) لاعب بأعمار (13-15) سنة, وبعد التحقق من التجانس لعينة البحث تم اجراء التكافؤ بين المجموعتين , واتبع الباحثان مجموعة من الاجراءات العلمية كالتجربة الاستطلاعية لاختبار مهارة التهديف ,واستغرق برنامج أنموذج وودز (6) اسابيع تقوم المجموعة التجريبية بتطبيقه بواقع وحدتين في الاسبوع , بمعدل وحدتين اسبوعياً , وقد توصلت الدراسة الى عدد من الاستنتاجات منها : الة تفوق برنامج أنموذج وودز على الاسلوب المتبع في تعلم مهارة التهديف , وكانت أهم التوصيات التي خلصت اليها الدراسة هو التوجه الى استخدام نماذج حديثة في التعلم الحركي ومنها أنموذج وودز, الاهتمام بالمدراس التخصصية وتوفير المستلزمات الحديثة في التعلم الحركي للمهارات الرياضية لخماسي كرة القدم.
Boas práticas para desinfecção de leitos de Unidade de Terapia Intensiva: Protocolo de revisão de escopo
Authors: Azevedo Thatyana Telles , Souza Cláudio José de , Silvino Zenith Rosa , Christovam Bárbara Pompeu , Camerini Flavia Giron , Brites André da Silva 
Published: January 2024

Objetivo: Mapear por meio da literatura científica as boas práticas utilizadas para a desinfecção concorrente e terminal de leitos de Unidades de Terapia Intensiva. Método: Protocolo de Revisão de escopo desenvolvido de acordo com as diretrizes do manual do Joanna Briggs Institute e checklist do Preferred Reporting Items for Systematic reviews e Meta-Analyses extension for Scoping Reviews (PRISMA – ScR). As fontes de buscas serão: Medical Literature Analysis and Retrievel System Online (MEDLINE) via PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILAC), SCOPUS, Web of Science, EMBASE. E como fonte de literatura cinzenta será utilizado a Biblioteca Digital de Teses e Dissertações (BDTD). Serão considerados estudos que atendam os critérios de inclusão, sem restrição de idioma e recorte temporal. As publicações serão selecionadas por dois revisores, de maneira independente, e se necessário um terceiro revisor participará em casos de divergências. Os dados serão extraídos utilizando o instrumento elaborado pelos revisores, e os resultados da pesquisa serão apresentados por meio de quadros, fluxogramas, gráficos e tabelas, e analisados descritivamente. Espera-se que com o desenvolvimento desta revisão de escopo que possam ser mapeadas as boas práticas existentes para a desinfecção de leitos de Unidades de Terapia Intensiva, e que ainda, possa ser possível a divulgação do conhecimento que impacte diretamente na qualidade da assistência prestada nos serviços de saúde fomentando a cultura de segurança.
A Desire Seeks Its Dwelling: Gendering Literature Teaching from the Contributions of Feminist Pedagogies
Authors: Sardi Valeria 
Published: January 2024

In this article I set about theorising the construction of a gendered didactic of literature, one that accounts for alternative ways of reading and approaching literary texts in school settings. Throughout my article, I intend to trouble literary reading practices insofar as they are socio-cultural, embodied, and sexed-and-gendered in nature. To do so, I will borrow from literature teaching experiences set in high schools 1 from the Buenos Aires province (Argentina). My writing will analyse pedagogical accounts of classroom happenings from the theoretical contributions of language and literature teaching, as well as from feminist, queer, and decolonial epistemologies and pedagogies. These theoretical approaches propose grappling with literature from local and embodied stances – against the grain of a colonial, capitalist, white, androcentric, encyclopaedistic, and hetero-cisnormative matrix – and, from that locus, seek to produce insights about alternative ways of conceptualising knowledge, pedagogical relationships, and the very subjects engaged in teaching and learning in pedagogical settings.
A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms
Authors: Zareian Nahid , Eremin Oleg , Pandha Hardev , Baird Richard , Kwatra Vineet , Funingana Gabriel , Verma Chandan , Choy Desmond , Hargreaves Steven , Moghimi Pejvak , Shepherd Adrian , Lobo Dileep N. , Eremin Jennifer , Farzaneh Farzin , Kordasti Shahram , Spicer James 
Published: January 2024

The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) peptides with concomitant therapies targeting regulatory T cells (Tregs) and cyclooxygenase-2 (COX2)-mediated immunosuppression. This Phase 1 trial combined an hTERT-derived 7-peptide library, selected to ensure presentation by both HLA class-I and class-II in 90% of patients, with oral low-dose cyclophosphamide (to modulate Tregs) and the COX2 inhibitor celecoxib. Adjuvants were Montanide and topical TLR-7 agonist, to optimise antigen presentation. The primary objective was determination of the safety and tolerability of this combination therapy, with anti-cancer activity, immune response and detection of antigen-specific T cells as additional endpoints. Twenty-nine patients with advanced solid tumours were treated. All were multiply-pretreated, and the majority had either colorectal or prostate cancer. The most common adverse events were injection-site reactions, fatigue and nausea. Median progression-free survival was 9 weeks, with no complete or partial responses, but 24% remained progression-free for ≥6 months. Immunophenotyping showed post-vaccination expansion of CD4+ and CD8+ T cells with effector phenotypes. The in vitro re-challenge of T cells with hTERT peptides, TCR sequencing, and TCR similarity index analysis demonstrated the expansion following vaccination of oligoclonal T cells with specificity for hTERT. However, a population of exhausted PD-1+ cytotoxic T cells was also expanded in vaccinated patients. This vaccine combination regimen was safe and associated with antigen-specific immunological responses. Clinical activity could be improved in future by combination with anti-PD1 checkpoint inhibition to address the emergence of an exhausted T cell population.
First-trimester urinary extracellular vesicles as predictors of preterm birth: an insight into immune programming
Authors: Huang Jian-Pei , Lin Chia-Hsueh , Tseng Chih-Wen , Chien Ming-Hui , Lee Hung-Chang , Yang Kuender D. 
Published: January 2024

Background: The programming of innate and adaptive immunity plays a pivotal role in determining the course of pregnancy, leading to either normal term birth (TB) or preterm birth (PB) through the modulation of macrophage (M1/M2) differentiation. Extracellular vesicles (EVs) in maternal blood, harboring a repertoire of physiological and pathological messengers, are integral players in pregnancy outcomes. It is unknown whether urinary EVs (UEVs) could serve as a non-invasive mechanistic biomarker for predicting PB.Methods: This study investigated first-trimester UEVs carrying M1 messengers with altered immune programming, aiming to discern their correlation to subsequent PB. A birth cohort comprising 501 pregnant women, with 40 women experiencing PB matched to 40 women experiencing TB on the same day, was examined. First-trimester UEVs were isolated for the quantification of immune mediators. Additionally, we evaluated the UEV modulation of “trained immunity” on macrophage and lymphocyte differentiations, including mRNA expression profiles, and chromatin activation modification at histone 3 lysine 4 trimethylation (H3K4me3).Results: We found a significant elevation (p &lt; 0.05) in the particles of UEVs bearing characteristic exosome markers (CD9/CD63/CD81/syntenin) during the first trimester of pregnancy compared to non-pregnant samples. Furthermore, UEVs from PB demonstrated significantly heightened levels of MCP-1 (p = 0.003), IL-6 (p = 0.041), IL-17A (p = 0.007), IP-10 (p = 0.036), TNFα (p = 0.004), IL-12 (p = 0.045), and IFNγ (p = 0.030) relative to those from TB, indicative of altered M1 and Th17 differentiation. Notably, MCP-1 (&gt;174 pg/mL) exhibited a sensitivity of 71.9% and specificity of 64.6%, and MCP-1 (&gt;174 pg/mL) and IFNγ (&gt;8.7 pg/mL) provided a higher sensitivity (84.6%) of predicting PB and moderate specificity of 66.7%. Subsequent investigations showed that UEVs from TB exerted a significant suppression of M1 differentiation (iNOS expression) and Th17 differentiation (RORrT expression) compared to those of PB. Conversely, UEVs derived from PB induced a significantly higher expression of chromatin modification at H3K4me3 with higher production of IL-8 and TNFα cytokines (p &lt; 0.001).Implications: This pioneering study provides critical evidence for the early detection of altered M1 and Th17 responses within UEVs as a predictor of PB and early modulation of altered M1 and Th17 polarization associated with better T-cell regulatory differentiation as a potential prevention of subsequent PB.
Menstrual disorders following COVID-19 vaccination: a review using a systematic search
Authors: Smaardijk Veerle R. , Jajou Rana , Kant Agnes , van Hunsel Florence P. A. M. 
Published: January 2024

Introduction:Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of the COVID-19 vaccines of Moderna and Pfizer. The aim of this review, using a systematic search, is to provide an overview of available literature on the risk of menstrual disorders after COVID-19 vaccination.Methods: The review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. A PubMed search was performed on 15 August 2023, including solely quantitative studies in English and Dutch.Results: A total of 61 studies were included, of which 40 were cross-sectional studies, 18 cohort studies, and three self-controlled case series. Outcomes included a wide variety of menstrual disorders, including changes in cycle length (n = 54), changes in the amount of bleeding (n = 44), changes in menses length (n = 30), changes in the experience of (pre)menstrual pain (n = 21), and breakthrough bleeding (n = 18). All included studies found a higher percentage of at least one menstrual disorder in the first cycle after different types of COVID-19 vaccination and after different doses.Discussion: In conclusion, evidence suggests that COVID-19 vaccines may cause menstrual changes in women of reproductive age. However, there is a need for more longitudinal studies because of important limitations in the study designs of many of the included studies. Although menstrual changes are short-lived and predominantly mild, it is important for women and healthcare professionals to be informed about these potential adverse reactions and to assess these events in clinical trials on vaccines.
Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease
Authors: Yan Peijing , Zhang Li , Yang Chao , Zhang Wenqiang , Wang Yutong , Zhang Min , Cui Huijie , Tang Mingshuang , Chen Lin , Wu Xueyao , Zhao Xunying , Zou Yanqiu , Xiao Jinyu , Liu Yunjie , Xiao Chenghan , Yang Yanfang , Zhang Ling , Yao Yuqin , Li Jiayuan , Liu Zhenmi , Yang Chunxia , Jiang Xia , Zhang Ben 
Published: January 2024

BackgroundThe relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms underlying these associations.MethodsWe first evaluated the phenotypic association between T2DM and GSD using data from the UK Biobank (n&gt;450,000) using a prospective observational design. We then conducted genetic analyses using summary statistics from a meta-analysis of genome-wide association studies of T2DM, with and without adjusting for body mass index (BMI) (Ncase=74,124, Ncontrol=824,006; T2DMadjBMI: Ncase=50,409, Ncontrol=523,897) and GSD (Ncase=43,639, Ncontrol=506,798).ResultsA unidirectional phenotypic association was observed, where individuals with T2DM exhibited a higher GSD risk (hazard ratio (HR)=1.39, P&lt;0.001), but not in the reverse direction (GSD→T2DM: HR=1.00, P=0.912). The positive T2DM-GSD genetic correlation (rg=0.35, P=7.71×10-23) remained even after adjusting for BMI (T2DMadjBMI: rg=0.22, P=4.48×10-10). Mendelian randomization analyses provided evidence of a unidirectional causal relationship (T2DM→GSD: odds ratio (OR)=1.08, P=4.6×10-8; GSD→T2DM: OR=1.02, P=0.48), even after adjusting for important metabolic confounders (OR=1.02, P=0.02). This association was further corroborated through a comprehensive functional analysis reflected by 23 pleiotropic single nucleotide polymorphisms, as well as multiple neural and motor-enriched tissues.ConclusionThrough comprehensive observational and genetic analyses, our study clarified the causal relationship between T2DM and GSD, but not in the reverse direction. These findings might provide new insights into prevention and treatment strategies for T2DM and GSD.