bluuebunny/crossref_metadata_2025_split huggingface dataset:
HAM simulation for bioconvective magnetohydrodynamic flow of Walters-B fluid containing nanoparticles and microorganisms past a stretching sheet with velocity slip and convective conditions
Authors: Yasmin Humaira , Mahnashi Ali M. , Hamali Waleed , Lone Showkat Ahmad , Saeed Anwar 
Published: December 2023

Abstract
In recent years, many numerical and analytical attempts have been reported by the researchers to explore the technological and industrial processes. Thermal management, hybrid-powered engine, microelectronics, heat exchanger, solar systems, energy generators are some recent applications of the heat and mass transfer flow. In this article, we have theoretically analyzed the convection flow of Walters-B fluid past a vertical extending surface. The Walters-B nanofluid contains the gyrotactic microorganisms and nanoparticles. The slip and convective conditions are imposed on the velocity and temperature equations. The modeled equations are reformed into the system of ordinary differential equations. Further, the transformed ordinary differential equations are solved analytically. The analytical results are compared with numerical solution and have found great resemblance to each other. The convergence analysis of analytical solution is also presented in this study. The impacts of the embedded factors on Walters-B nanofluid have been presented and deliberated in detail. The results show that the improvement in viscoelastic and magnetic parameter declined the nanofluid motion for both slip and no-slip conditions. The escalated mixed convection parameter has augmented the nanofluid motion. Additionally, at the surface of sheet, the slip condition reduces the fluid motion, however, away from the stretching surface, an increasing conduct up-to some points and then free stream velocity is found. The increased bioconvection Lewis number has increased the microorganisms’ profile while the greater bioconvection Peclet number has increased the microorganisms’ profiles reduced. The streamline patterns for Newtonian, non-Newtonian, magnetized, and non-magnetized cases have different behaviors. The flow factors have dominant impact on velocity profiles for the case of slip condition.
A Developmental Switch in Cholinergic Mechanisms of Modulation in the Medial Nucleus of the Trapezoid Body
Authors: Weimann Sonia R. , Zhang Chao , Burger R. Michael 
Published: December 2023

The medial nucleus of the trapezoid body (MNTB) has been intensively investigated as a primary source of inhibition in brainstem auditory circuitry. MNTB-derived inhibition plays a critical role in the computation of sound location, as temporal features of sounds are precisely conveyed through the calyx of Held/MNTB synapse. In adult gerbils, cholinergic signaling influences sound-evoked responses of MNTB neurons via nicotinic acetylcholine receptors (nAChRs) (Zhang et al., 2021) establishing a modulatory role for cholinergic input to this nucleus. However, the cellular mechanisms through which acetylcholine (ACh) mediates this modulation in the MNTB remain obscure. To investigate these mechanisms, we used whole-cell current and voltage-clamp recordings to examine cholinergic physiology in MNTB neurons from Mongolian gerbils(Merionas unguiculatis)of both sexes. Membrane excitability was assessed in brain slices, in pre- (p9-13) and post-hearing onset (p18-20) MNTB neurons during bath application of agonists and antagonists of nicotinic (nAChRs) and muscarinic receptors (mAChRs). Muscarinic activation induced a potent increase in excitability most prominently prior to hearing onset with nAChR modulation emerging at later time points. Pharmacological manipulations further demonstrated that the voltage gated K+channel KCNQ (Kv7) is the downstream effector of mAChR activation that impacts excitability early in development. Cholinergic modulation of Kv7 reduces outward K+conductance and depolarizes resting membrane potential. Immunolabeling revealed expression of Kv7 channels as well as mAChRs containing M1 and M3 subunits. Together, our results suggest that mAChR modulation is prominent but transient in the developing MNTB and that cholinergic modulation functions to shape auditory circuit development.Significance statementThis study is the first to examine downstream cellular mechanisms that underlie modulatory effects of acetylcholine (ACh) in MNTB neurons. The MNTB is a primary source of inhibition in the superior olive and features the calyx of Held, an intensively studied giant synapse that plays a pivotal role in precise encoding of acoustic cues. Recently, we discovered that ACh modulates MNTB responses in adult gerbils through nicotinic receptors. Here, we demonstrate that ACh has potent effects on membrane excitability prior to hearing onset primarily via muscarinic receptors and describe the expression of two muscarinic receptor subtypes. Our results suggest that developmentally transient cholinergic modulation of a voltage-gated K+conductance is poised to influence circuit development during the peri-hearing onset period.
TASAVVUF MÛSİKÎSİ DERNEKLERİ FEDERASYONU’NUN TÜRK DİN MÛSİKÎSİ UYGULAMALARI
Authors: AKKUŞ Mustafa Asım 
Published: December 2023

Bu çalışmada İstanbul Bağcılar’da kurulmuş, Kâdirî ve Rifâî temelli bir tarikat olan
Cevherîliğin Türk din mûsikîsi uygulamalarının ortaya konulması amaçlanmıştır. Öncelikle
Cevherîliğin kurulmasındaki tarihsel sürece değinilmiş, akabinde kültürel anlamda yayılmasını
sağlayan Tasavvuf Mûsikîsi Dernekleri Federasyonu’nun mûsikî faaliyetleri ele alınmıştır. Arşivler,
mülâkatlar ve gözlemler neticesinde Cevherîliğin mûsikî ile ilişkisi saptanmış, zikirde icrâ edilen
mûsikî türleri ve tekkeye ait besteler tespit edilmiştir. Buna ilâveten, yapılan araştırmalar sonucunda
elde edilen ses kayıtları, nota arşivleri vesilesiyle tekkeye mahsus eserler düzenlenerek notaya
alınmış ve Türk din mûsikîsi repertuvarının yeni eserlerle tanışması amaçlanmıştır. Salâvat, imâmet,
tesbihât, istiğfar, terâvih tertibi, kaside ve ilâhiler gibi türler tekkede icrâ edilmekte ve özellikle
uşşak, rast, hicaz, segah makamındaki salâvat ve tesbihâtın besteleri tekkeye mahsus olarak
okunmaktadır. Ayrıca meşk akşamları da tertip edilmekte ve birçok ilâhi, şuğl, tevşih, nefes,
mersiye vb. besteli türler okunmaktadır. Yapılan bu çalışmanın problem durumu “Cevherîliğin zikir
ve mûsikî ilişkisi uyumlu mudur? Cevherîliğin Türk din mûsikîsi’ndeki yeri nedir?” olarak tespit
edilmiştir. Yöntem olarak çalışmamızda nitel araştırma yöntemlerinden kaynak tarama, veri
toplama, örnekleme, karşılaştırma, kaynak gösterme gibi yöntemlere başvurulmuştur. Bu
çalışmanın önemini ise, Cevherîliğin mûsikîyi etkili bir şekilde kullanması, birçok mûsikîşinas ve
bestekâr yetiştirmesi sebebiyle mûsikî ile ilişkisinin önem arz etmesi olarak ifâde edebiliriz.
La infracción y el delito fiscal bajo la óptica de la teoría del ius puniendi único del Estado y los derechos humanos
Authors: Díaz Reyes Alejandro , Vázquez Avedillo José Fernando 
Published: December 2023

Esta investigación tiene como objeto analizar la infracción y el delito, que constituyen figuras jurídicas de naturaleza punitiva en el ámbito tributario, en las cuales su tipificación legal se da en ejercicio del derecho a castigar del Estado bajo la necesidad de protección de los ingresos fiscales del Estado que le permitan realizar sus finalidades.
Este análisis parte del estudio de las distintas teorías que se disputan la titularidad del ius puniendi, para arribar a la teoría que propone a la entidad estatal como la única titular del derecho a castigar a través del derecho administrativo sancionador y del derecho penal, donde se regulan las conductas ilícitas consideradas como infracción o como delito. Dicha circunstancia permitirá examinar el ejercicio del ius puniendi por parte de las autoridades en el ámbito fiscal a la luz de los derechos humanos que limitan el ejercicio de esta potestad punitiva.
A Data Warehouse Architecture Proposal and ETL Analysis, Case study of an Albanian Banking System
Authors: MILLO Denisa , BACI Nevila , TAHIRAJ Shpresim 
Published: December 2023

The increasing phenomenon of information overload is a direct result of the ongoing trend to reduce the cost of data distribution while the development of data processing platforms is not fast enough. Therefore, sending packets of data is not a big issue, but processing an increasing amount of data is a big challenge.
Data Warehouse is a concept born in the late ‘80s and has been improved decade after decade with the growth of technology. Despite many application areas, the data warehouse concept is still new and unknown to Albanian businesses and companies with a large amount of data to store and analyze.
This paper aims to provide an in-depth analysis of the concept of a data warehouse, the different architectures applied, and the Extract, Transform Load (ETL) process. The ETL process as a concept consists of extracting the data from a source, transforming them into different formats or dimensions, and then loading them somewhere to be checked for analysis or other purposes.
In this paper, we can find different definitions of the data warehouse, where it can be implemented, the different architectures according to the need of the users, and how the ETL process works. The last chapter implements a data warehouse for the banking system seen from a Management Information Systems perspective followed by an application of a step-by-step ETL procedure.
Climate Change, Large Risks, Small Risks, and the Value per Statistical Life
Authors: Alberini Anna , Scasny Milan 
Published: December 2023

Abstract

We conduct a contingent valuation survey in Spain and the UK to elicit information about the WTP for heat wave watch and response programs. We find that people are willing to pay for such programs, and that the WTP (€ 50 for each of 10 years; 2019 PPP euro) is virtually the same across the two countries and across respondents that received two alternate presentations of the mortality risks with and without the programs. The responses to the WTP questions are internally consistent. Persons who re-assessed their own risks as “very high” after reading the questionnaire’s information about the health effects of excessive heat are prepared to pay more for these programs. These persons are in poor health and less highly educated, and thus an important priority for outreach and education efforts by heat wave watch and response programs. That people value saving lives during heat waves as important is confirmed by the results of person tradeoffs, which show that avoiding a fatality during heat waves is comparable to avoiding a cancer fatality, is slightly more valuable than an avoiding a cardiovascular fatality, and definitely more valuable than an avoided road traffic fatality. The Value per Statistical Life implied by the WTP for the programs is € 1.1 million to € 4.7 million (2019 PPP euro), depending on the size of the mortality risk reduction valued by the respondent, for an average of € 1.6 million.
RSV-bacterial co-infection is associated with increased illness severity in hospitalized children - Results from a prospective sentinel surveillance study
Authors: Torres Ana Rita , Gaio Vânia , Melo Aryse , Lança Miguel , Barreto Marta , Gomes Licínia , Azevedo Inês , Bandeira Teresa , Lito David , Guiomar Raquel , Rodrigues Ana Paula , group VigiRSV 
Published: December 2023

Abstract

Purpose: During the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects the severity of the disease. We aimed to understand the relationship between RSV-bacterial co-infections and clinical severity since the change of RSV seasonality after the COVID-19 pandemic.
Methods: We conducted a prospective, sentinel surveillance study at 20 sites in Portugal in children under two years old hospitalized with RSV, between April 2021 and January 2023. The effect of co-infection with potentially pathogenic bacteria (PPB) on the length of hospitalization and disease severity (defined by the need for ventilation or admission to an intensive care unit-ICU) was investigated using multivariate linear and log-binomial regression models. Age group (<6 months/≥6 months) and prematurity (yes/no) were included in models as potential confounders.
Results: We report two RSV off-season epidemics: June 2021-February 2022 and May-October 2022. Among 678 RSV hospitalizations, 67.4 % occurred in children under 6 months old and 15.3 % in pre-term; 20.4 % tested positive for PPB; median length of hospitalization was five days (IQR: 3-7days); 5.8 % had at least one underlying condition. The most common bacteria were Haemophilus influenzae and Streptococcus pneumoniae. Children co-infected with PPB had a higher rate of ICU admission (29.7 % versus 3.5 %, p<0.001), resulting in more prolonged hospitalizations (median of 7 days versus 5 days, p<0.001) and a 13-fold risk of having severe disease (RR: 13.2, 95 CI: 7.3-23.9).
Conclusion: RSV-bacterial co-infection was associated with increased length of hospitalization and severe illness during off-season epidemics. This risk is probably overestimated, as laboratory testing for bacterial infections is usually higher in severely ill-appearing children. Measures to prevent outgrowth of pathogenic bacteria within the respiratory tract should be discussed.
Stingless bee foraging activity related to environmental aspects
Authors: de Moura Marcos Estevan Kraemer , Faita Márcia Regina , Bertoldo Juliano Garcia , Poltronieri Alex Sandro , Contrera Felipe Andrés Leon 
Published: December 2023

Abstract

The environment where bee colonies are inserted must provide the necessary resources for their survival. Given this, any environmental changes can affect the development and survival of colonies. We evaluated the foraging activity of Plebeia droryana (Friese), Scaptotrigona bipunctata (Lepetelier) and Melipona quadrifasciata (Lepetelier) in areas with different land uses and land cover. These areas were classified as predominantly i) urbanized (area 1), ii) agricultural (area 2) and iii) with dense vegetation (area 3). We correlated the morphometric characteristics of the bees with the pollen load transported. Four colonies belonging to each species were installed in the three areas. We recorded light, wind speed, humidity and temperature and counted workers returning with nectar, pollen and resin. Plebeia droryana and S. bipunctata collected more resin and nectar in area 3 compared to area 2. Scaptotrigona bipunctata collected more pollen in areas 1 and 3, and M. quadrifasciatadid not show differences in foraging activity between areas. Plebeia droryana and M. quadrifasciata showed moderate and strong correlations for morphometric characteristics and pollen load. Smaller species showed greater collection of resources in the area predominantly covered by dense vegetation. The reduction of vegetation cover can affect the resource collection activity of stingless bees.
Statistical Modeling of Indus River Outflow at Tarbela Dam using Generalized Gumbel Type 2 Distribution
Authors: Ateeq Kahkashan , Qasim Tahira Bano , Kiran Wajeeha 
Published: December 2023

Abstract

The Indus River, a lifeline for Pakistan, holds paramount significance for its geography, history, and economy. This research delves into a comprehensive analysis of the river's behavior by introducing a novel statistical framework. Leveraging the Gumbel Type 2 distribution and the Rayleigh distribution, a new generalized Gumbel Type 2 (GG2) distribution is derived, and used for modeling the data about the river's outflow at the Tarbela Dam during 2020–2021. Our study contributes to the understanding of the complex dynamics of the Indus River, aiding in the sustainable management of its resources. The GG2 distribution, designed for extreme value events, adept at modeling positive-valued variables, were combined to model the intricate characteristics of the river's flow. Parameters were estimated using both classical and Bayesian methods, enhancing the accuracy and reliability of our findings. The incorporation of Bayesian techniques adds robustness to our parameter estimates and allows for a more comprehensive uncertainty analysis. The results not only deepen our understanding of the river's behavior but also offer insights crucial for infrastructure planning, flood control, and resource allocation.
Supramolecular Polynuclear Clusters Mediated Assembly of Cubic Hydrogen-Bonded Organic Frameworks with Octahedral Cages for Reversible Photochromism
Authors: Ye Gang , Ding Xiaojun , Chen Jing 
Published: December 2023

Abstract
Developing supramolecular porous crystalline frameworks with tailor-made architectures from advanced secondary building units (SBUs) remains a pivotal challenge in reticular chemistry. Particularly for hydrogen-bonded organic frameworks (HOFs), construction of geometrical cavities through secondary units has been rarely achieved. Herein, a body-centered cubic HOF (TCA_NH4) with octahedral cages was constructed by a C3-symmetric building block and NH4+ node-assembled cluster (NH4)4(COOH)8(H2O)2 that served as supramolecular secondary building units (SSBUs), akin to the polynuclear SBUs in reticular chemistry. Specifically, the octahedral cages could encapsulate four homogenous haloforms including CHCl3, CHBr3, and CHI3 with truncated octahedron configuration. Crystallographic evidence revealed the cages served as spatially-confined nanoreactors, enabling fast, broadband photochromic effect associated with the reversible photo/thermal transformation between encapsulated CHI3 and I2. Overall, this work provides a new strategy by shaping SSBUs to expand the framework topology of HOFs, and a new prototype of hydrogen-bonded nanoreactors to accommodate reversible photochromic reactions.
Oncologists’ Perceptions of Tumor Genomic Profiling and Barriers to Communicating Secondary Hereditary Risks to African American Cancer Patients
Authors: Hall Michael J , D’Avanzo Paul A , Chertock Yana , Kelly Patrick JA , Brajuha Jesse , Singley Katie , Luck Caseem , Bass Sarah Bauerle 
Published: December 2023

Abstract
Background Tumor genomic profiling (TGP) identifies targets for precision cancer treatments, but also secondary hereditary risks. Oncologists are poorly trained to communicate these results, especially among patients with lower health literacy, poorer genetics knowledge, and higher mistrust. African American (AA) patients are especially vulnerable due to significant cancer disparities and lower uptake of TGP.Methods This mixed-methods study used semi-structured interviews of oncologists to inform development of an online survey with a convenience sample of US-based oncologists (n = 50) to assess perceptions of the challenges of TGP and communicating results to AA patients.Results Most interviewed oncologists felt it was important to consider racial/cultural differences when communicating about hereditary risks. Cost, family dynamics, discrimination concerns, and medical mistrust were identified as particularly salient. Survey respondents’ views related to AAs and perceptions of TGP were strongly associated with years since completing training, with recent graduates expressing stronger agreement with statements identifying barriers/disadvantages to TGP for AA patients.Conclusions Oncologists who had more recently completed training expressed more negative perceptions of TGP and more perceived challenges in communicating about TGP with their AA patients. Focused training for oncologists that address barriers specific to AAs may be helpful in supporting improved communication about TGP.
Population genomics of an accidental pathogen Streptococcus mitis from patients with bloodstream infection and infective endocarditis in the UK and Ireland
Authors: Kalizang'oma Akuzike , Richard Damien , Kwambana-Adams Brenda , Coelho Juliana , Broughton Karen , Pichon Bruno , Hopkins Katie , Chalker Victoria , Beleza Sandra , Bentley Stephen , Chaguza Chrispin , Heyderman Robert 
Published: December 2023

Abstract

Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of IE-associated S. mitis is hampered by low IE incidence. Here we use whole genome sequencing of 217 S. mitis bloodstream infection (BSI) isolates collected between 2001–2016 from clinically diagnosed IE cases in the UK to investigate genetic diversity, antimicrobial resistance, and pathogenicity. We show high genetic diversity of IE-associated S. mitis with virtually all isolates belonging to distinct lineages indicating no predominance of specific lineages. Additionally, we found a highly variable distribution of known pneumococcal virulence genes among the isolates, some of which were overrepresented in the disease than contextual carriage strains. Our findings suggest that S. mitis in patients with clinically diagnosed IE is not primarily caused by specific hypervirulent or antimicrobial resistant lineages, highlighting the accidental pathogen nature of S. mitis in patients with clinically diagnosed IE.
Effect of hypoxic stress on the glycolytic pathway of Onchidium reevesii
Authors: Chen Feng , Tang Liusiqiao , Sun Mingyin , Rao Changhao , Zhao Fengsheng , Bai Xueying , Zhou Qinglan , Shen Heding 
Published: December 2023

Abstract
The escalating incidence of hypoxia in intertidal environs, a consequence of global warming and eutrophic episodes, presents a formidable peril to the biota ensconced within these precincts. This inquiry delves into whether Onchidium reevesii, a denizen of the intertidal sphere, harnesses the glycolytic sequence to derive energy and surmount hypoxic adversity. To this end, the pivotal gene implicated in the glycolytic cascade, termed OrGLUT-1, was replicated and subjected to a bioinformatic dissection. The technology of Real-Time Quantitative Polymerase Chain Reaction (qPCR) was employed to assess the transcriptional abundance of OrGLUT-1within diversified tissues of O.reevesii, most notably the central nervous system and hepatopancreas, during anoxic duress. Additionally, the study scrutinized alterations in genes germane to energy metabolism—namely hexokinase(HK) and pyruvate kinase (PK)—within the aforementioned tissues and highlighted enzymatic fluxes pertaining to Hexokinase, Pyruvate kinase, and Lactate dehydrogenase under similarly austere conditions. The findings disclose that OrGLUT-1's cDNA spans a length of 2,386 base pairs, and boasts a pronounced expression in both the central nervous substrate as well as hepatic digestion glands. Notably, hypoxia precipitated discernible modulation in the transcripts of OrGLUT-1, alongside genes HK and PK, within both neural and hepatopancreatic tissues. Concomitantly, the enzymatic vigor of HK, PK, and LDH in neural matter evinced an escalatory pattern, suggesting that O.reevesiimight indeed resort to the glycolytic route for energy acquisition amidst oxygen-scarce habitats. Collectively, these revelations furnish pivotal comprehension into the adaptive stratagems of O.reevesii under hypoxic conditions and could potentially undergird strategies tailored to shield organisms within the intertidal zones from the ravages of anoxic stress.