bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial degradation of pyridine: a proposed nitrogen metabolism pathway deciphered in marine mangrove Bacillus aryabhattai strain NM1-A2
Authors: Kashif Muhammad , Bai Lirong , Xiong Jianwen , Mo Shuming , Sang Yimeng , Huang Kunmei , Song Jingjing , Shah Syed Jalil , Khan Sohail , Khan Taj Malook , Jiang Chengjian 
Published: December 2023

Abstract
Background
Diverse microbes, such as bacteria, are of immense worth to mangrove ecosystems due to their adaptability to salinity and variable environmental characteristics conditions. Pyridine and its derivatives compose most heterocyclic aromatic compounds largely produced by human activities that lead to environmental pollution. Bacteria have a crucial role in the nutrient cycling of carbon and nitrogen etc., to understand their functional involvement with environmental factors or ecosystem functioning as well as the species invasion and domestic or agriculture pyridine degradation pollution activities that threaten the mangrove ecosystem.

Methods
This work established the genetic-based molecular degradation of organic compounds in the mangrove ecosystem, which ultimately makes the availability of nutrients. As well as the effects of various abiotic factors on pyridine degradation to discover the pyridine degradation and the removal of ammonia nitrogen and the proposed nitrogen metabolism pathway.

Results
The novel bacterial strain NM1-A2 was isolated from mangrove sediments and, after 16S rRNA gene sequence analysis identified as Bacillus aryabhattai. NM1-A2 completely degraded pyridine within a 100 h incubation period at a temperature of 35 °C, an initial pH of 7.0, glucose and a pyridine concentration of 500 mg/L. The pseudo-first-order kinetics model described the pyridine biodegradation profile of NM1-A2 well. Interestingly, within 96 h the strain achieved almost complete pyridine degradation with a total organic carbon (TOC) removal of 87.9% ± 0.19% (from 377.52 ± 6.9 mg/L to 45.65 ± 0.14 mg/L). Within 96 h, the pyridine ring in the total nitrogen (TN) fraction at the maximum concentration of 55.31 ± 0.17 mg/L, furtherly 51.3% ± 2.39% of (TN) converted into Ammonia nitrogen (NH4+-N). Furthermore, NM1-A2 exhibited its pyridine biodegradation activity decreased by only 4% after three consecutive cycles (48 h each). Moreover, NM1-A2 possessed nrt-ABCD nitrate transport family and gltABCD operons that participate in the activities of glutamine and glutamate synthetase in NH4+ conversion in the nitrogen cycle. Furthermore, the nitrogen metabolism genes (nrtA, nrtB, nrtC, nirB, nirD, gltB, gltD, glnA) exhibited expression in NM1-A2.

Conclusion
This research offers a potential treatment strategy for pyridine degradation in the mangrove ecosystem.

Graphical Abstract
Altering chromatic aberration: how this latest trend in intraocular-lens design affects visual quality in pseudophakic patients
Authors: Łabuz Grzegorz , Güngör Helin , Auffarth Gerd U. , Yildirim Timur M. , Khoramnia Ramin 
Published: December 2023

Abstract
Background
Chromatic aberration of the eye results from the dispersion of polychromatic light at the interfaces of ocular media. An intraocular lens (IOL) based approach utilizing the diffractive-multifocal principle has been proposed for its correction, but the clinical evidence on the impact of reducing or increasing chromatic aberration on the visual quality of pseudophakic patients remains scarce.

Methods
In this cross-sectional study, longitudinal chromatic aberration (LCA) effects were studied monocularly in 37 patients implanted with a monofocal lens. LogMAR corrected distance visual acuity (VA) and defocus curve at the + 1.0 D to − 2.0 D range were assessed. Contrast sensitivity (CS) was evaluated at far and at four spatial frequencies. Measurements were performed with the eye's natural conditions, as well as with increased and corrected (by the same amount) LCA, which was altered by introducing zero-power trial triplets.

Results
The mean (± standard deviation) logMAR VA was − 0.11 ± 0.07 for the natural condition, − 0.13 ± 0.07 for the LCA-corrected eye, and − 0.06 ± 0.08 for the eye with increased LCA. A sharp decline of the defocus tolerance was found after the LCA correction with the VA value of 0.38 ± 0.15 logMAR at − 1.5 D. However, for the natural and increased LCA, it was 0.32 ± 0.16 logMAR and 0.25 ± 0.13 logMAR, respectively. CS was improved at all spatial frequencies after the LCA correction, which was closely followed by the natural-eye performance. Increased LCA resulted in reduced CS, mainly at higher spatial frequencies.

Conclusions
We demonstrated that elevating chromatic aberration above the natural level of monofocal patients extends their depth of focus while causing a measurable albeit minimal reduction in visual function. Still, the observed changes indicate that neither correction nor increase of LCA yields a substantial clinical effect on distance VA and CS in monofocal pseudophakia.
Variability of transient elastography-based spleen stiffness performed at 100 Hz
Authors: Armandi Angelo , Merizian Talal , Werner Merle Marie , Coxson Harvey O. , Sanavia Tiziana , Birolo Giovanni , Gashaw Isabella , Ertle Judith , Michel Maurice , Galle Peter R. , Labenz Christian , Emrich Tilman , Schattenberg Jörn M. 
Published: December 2023

Abstract
Background
Spleen stiffness measurement (SSM) performed by transient elastography at 100 Hz is a novel technology for the evaluation of portal hypertension in advanced chronic liver disease, but technical aspects are lacking. We aimed to evaluate the intraexamination variability of SSM and to determine the best transient elastography protocol for obtaining robust measurements to be used in clinical practice.

Methods
We analyzed 253 SSM exams with up to 20 scans for each examination, performed between April 2021 and June 2022. All SSM results were evaluated according to different protocols by dividing data into groups of n measurements (from 2 to 19). Considering as reference the median SSM values across all the 20 measurements, we calculated the distribution of the absolute deviations of each protocol from the reference median. This analysis was repeated 1,000 times by resampling the data. Distributions were also stratified by etiology (chronic liver disease versus clinically significant portal hypertension) and different SSM ranges: < 25 kPa, 25–75, and > 75 kPa.

Results
Overall, we observed that the spleen stiffness exam had less variability if it exceeded 12 measurements, i.e., absolute deviations ≤ 5 kPa at 95% confidence. For exams with higher SSM values (> 75 kPa), as seen in clinically significant portal hypertension, at least 15 measurements are highly recommendable.

Conclusions
Fifteen scans per examination should be considered for each SSM exam performed at 100 Hz to achieve a low intraexamination variability within a reasonable time in clinical practice.

Relevance statement
Performing at least 15 scans per examination is recommended for 100 Hz SSM in order to achieve a low intraexamination variability, in particular for values > 75 kPa compatible with clinically significant portal hypertension.

Key points
• Spleen stiffness measurement by transient elastography is used for stratification in patients with portal hypertension.
• At 100 Hz, this method may have intraexamination variability.
• A minimum of 15 scans per examination achieves a low intraexamination variability.

Graphical Abstract
A new genus and two new species with some new records of the subfamily Campopleginae (Hymenoptera: Ichneumonidae) from Iran
Authors: Karimi Soroush , Ghassemi-Kahrizeh Akbar , Hosseinzadeh Abbas , Lotfalizadeh Hossein , Riedel Matthias 
Published: December 2023

AbstractBackgroundThe Campopleginae is the third largest subfamily of Ichneumonidae in the world and Iran.ResultsDuring a study of the family Ichneumonidae in northwestern Iran, we collected 30 species of the subfamily Campopleginae. One genus,ParameloborisRiedel, and two species,Diadegma persicumRiedelsp. nov.andParameloboris nigrocephalusRiedelsp. nov., are new to science described and illustrated here. Nine species are recorded for the first time for the fauna of Iran. A checklist of the Iranian members of Campopleginae was provided showing the geographical distribution in Iran. A new name,Dusona rufigasterRiedel, Mohammadi-Khoramabadib and Khayrandish, 2019 proposed for preoccupied by Walley, 1940 a new name,Dusona rufitergusRiedel & Karimi is proposed here.ConclusionsThe number of identified species of the subfamily Campopelgine in Iran increased to 94 species.
Impulsivity, depression, and suicide in female patients with polycystic ovary syndrome and infertility
Authors: Gomaa Maged A. , Desoky Asmaa A. , Amer Dalal , Alaa Doaa , Khalil Mohamed A. 
Published: December 2023

Abstract
Background
Polycystic ovary syndrome (PCOS) is a common cause of infertility associated with multiple medical and psychiatric complications. The study compared suicide, impulsivity, and depression in females with PCOS to females with other causes of infertility.

Methods
Sixty females with infertility were included in two groups. Group A included 30 females with PCOS and infertility, while group B included 30 females with infertility for other causes than PCOS. The assessment included infertility workup, medical history, hormonal profile, Beck depression inventory (BDI), Short Version of the UPPS-P Impulsive Behavior Scale, and Columbia Suicide Severity Rating Scale.

Results
Group A had higher numbers of patients with depression (p-value = 0.04) and higher BDI (p-value = 0.001). Negative urgency, positive urgency, and sensation-seeking were higher in PCOS patients (p-value = 0.001, 0.03, 0.04). A significant positive correlation was found between sensation-seeking, BDI scores (p = 0.01), and LH level (p = 0.03).

Conclusions
It was concluded that patients with PCOS have more depression and impulsivity than patients with other causes of infertility. Suicide was not different in both groups.
Investigation of the relationship between oral motor feeding development and gross motor development between preterm and term infants at 10- to 12-month postnatal age
Authors: Erol Erkan , Apaydın Umut , Demir Numan , Elbasan Bülent 
Published: December 2023

Abstract
Background
Immature central nervous system, extended stay in the neonatal intensive care unit, and sensory experience deficiency may contribute to oral and gross motor delay in preterm infants. Current study aimed to investigate oral and motor development in preterm infants.

Methods
Twenty-nine preterm infants and 28 term infants were evaluated within the scope of the study. Oral motor feeding development was assessed with the Schedule for Oral Motor Assessment, and motor development was evaluated with the Alberta Infant Motor Scale. All analyses were performed using SPSS 22. The study was approved by the Gazi University Clinical Researches Ethics Committee (no: 25901600–23).

Results
There was a correlation between the Schedule for Oral Motor Assessment categories (solid, semisolid, cracker, puree, bottle, and cup) and the Alberta Infant Motor Scale score (p < 0.05). There was a significant difference between groups in the Schedule for Oral Motor Assessment’s solid, semisolid, cracker, and puree categories and total score (p < 0.05). There was a significant difference between groups regarding the Alberta Infant Motor Scale score (p < 0.05).

Conclusion
Preterm infants come behind their term peers in motor and oral motor feeding performance. These two areas of development can influence each other. For this reason, oral motor feeding problems should be emphasized as well as motor problems in physiotherapy rehabilitation evaluations.
Efficacy of a short message service brief contact intervention (SMS-SOS) in reducing repetition of hospital-treated self-harm: randomised controlled trial
Authors: Stevens Garry John , Sperandei Sandro , Carter Gregory Leigh , Munasinghe Sithum , Hammond Trent Ernest , Gunja Naren , de la Riva Anabel , Brakoulias Vlasios , Page Andrew 
Published: December 2023

BackgroundHospital-treated self-harm is common and costly, and is associated with repeated self-harm and suicide.AimsTo investigate the effectiveness of a brief contact intervention delivered via short message service (SMS) text messages in reducing hospital-treated self-harm re-presentations in three hospitals in Sydney (2017–2019), Australia. Trial registration number: ACTRN12617000607370.MethodA randomised controlled trial with parallel arms allocated 804 participants presenting with self-harm, stratified by previous self-harm, to a control condition of treatment as usual (TAU) (n = 431) or an intervention condition of nine automated SMS contacts (plus TAU) (n = 373), over 12 months following the index self-harm episode. The primary outcomes were (a) repeat self-harm event rate (number of self-harm events per person per year) at 6-, 12- and 24-month follow-up and (b) the time to first repeat at 24-month follow-up.ResultsThe event rate for self-harm repetition was lower for the SMS compared with TAU group at 6 months (IRR = 0.79, 95% CI 0.61–1.01), 12 months (IRR = 0.78, 95% CI 0.64–0.95) and 24 months (IRR = 0.78, 95% CI 0.66–0.91). There was no difference between the SMS and TAU groups in the time to first repeat self-harm event over 24 months (HR = 0.96, 95% CI 0.72–1.26). There were four suicides in the TAU group and none in the SMS group.ConclusionsThe 22% reduction in repetition of hospital-treated self-harm was clinically meaningful. SMS text messages are an inexpensive, scalable and universal intervention that can be used in hospital-treated self-harm populations but further work is needed to establish efficacy and cost-effectiveness across settings.
Endotrophin, a Key Marker and Driver for Fibroinflammatory Disease
Authors: Henriksen Kim , Genovese Federica , Reese-Petersen Alexander , Audoly Laurent P , Sun Kai , Karsdal Morten A , Scherer Philipp E 
Published: December 2023

Abstract
Our overview covers several key areas related to recent results obtained for collagen type VI and endotrophin (ETP). (1) An introduction to the history of ETP, including how it was identified, how it is released, and its function and potential receptors. (2) An introduction to the collagen family, with a focus on what differentiates collagen type VI from an evolutionary standpoint. (3) An overview of collagen type VI, the 6 individual chains (COL6A1, A2, A3, A4, A5, and A6), their differences and similarities, as well as their expression profiles and function. (4) A detailed analysis of COL6A3, including the cleaved product endotrophin, and what separates it from the other 5 collagen 6 molecules, including its suggested function based on insights gained from knockout and gain of function mouse models. (5) The pathology of ETP. What leads to its presence and release and what are the consequences thereof? (6) Functional implications of circulating ETP. Here we review the data with the functional roles of ETP in mind. (7) We propose that ETP is a mediator for fibrotic (or fibroinflammatory) disorders. Based on what we know about ETP, we have to consider it as a target for the treatment of fibrotic (or fibroinflammatory) disorders. What segment(s) of the patient population would most dramatically respond to an ETP-targeted intervention? How can we find the population that would profit most from an intervention? We aim to present a broad overview over the ETP field at large, providing an assessment of where the future research efforts need to be placed to tap into the vast potential of ETP, both as a marker and as a target in different diseases.
Gonadal Function in Boys with Bilateral Undescended Testes
Authors: Lucas-Herald Angela K , Alkanhal Khalid I , Caney Emma , Malik Iman , Alimussina Malika , McNeilly Jane D , Bradnock Timothy , Lee Boma , Steven Mairi , Flett Martyn , O’Toole Stuart , McGowan Ruth , Faisal Ahmed S 
Published: December 2023

Abstract

Background
Bilateral undescended testes (BUDT) may be a marker of an underlying condition that affects sex development or maturation.

Aims
To describe the extent of gonadal dysfunction in cases of BUDT who had systematic endocrine and genetic evaluation at a single tertiary pediatric center.

Methods
A retrospective review was conducted of all boys with BUDT who had endocrine evaluation between 2008 and 2021 at the Royal Hospital for Children, Glasgow (RHCG). Continuous variables were analyzed using Mann–Whitney U and non-continuous variables using Fisher’s exact, via Graphpad Prism v 8.0. Multivariable logistic regression was used to identify any associations between groups. A P &lt; .05 was considered statistically significant.

Results
A total of 243 bilateral orchidopexies were performed at RHCG between 2008 and 2021. Of these 130 (53%) boys were seen by the endocrine team. The median (range) age at first orchidopexy was 1 year (0.2, 18.0) with 16 (12%) requiring re-do orchidopexy. The median External Masculinization Score of the group was 10 (2, 11) with 33 (25%) having additional genital features. Of the 130 boys, 71 (55%) had extragenital anomalies. Of the 70 who were tested, a genetic abnormality was detected in 38 (54%), most commonly a chromosomal variant in 16 (40%). Of the 100 who were tested, endocrine dysfunction was identified in 38 (38%).

Conclusion
Genetic findings and evidence of gonadal dysfunction are common in boys who are investigated secondary to presentation with BUDT. Endocrine and genetic evaluation should be part of routine clinical management of all cases of BUDT.
Palliative Care and Care Partner Support in Neuro-oncology
Authors: Sharma Akanksha 
Published: December 2023

ABSTRACT
The journey for a patient with a brain tumor and their loved ones can be extremely challenging due to the high burden of physical symptoms and the emotional distress caused by the diagnosis. Optimizing quality of life by addressing symptoms and reducing this emotional distress can improve treatment tolerance and outcomes and alleviate care partner distress and burden. Symptoms in patients with central nervous system (CNS) tumors can vary in onset and intensity, ranging from headaches, seizures, and focal weakness to emotional distress and cognitive dysfunction. Additionally, care partners may demonstrate distress due to the high burden of care and need appropriate support structures and access to resources to alleviate this stress. Evidence-based recommendations are unfortunately limited given the lack of high-quality research in this area, but patients living with CNS tumors and their loved ones can benefit from early and routine symptom identification and management, compassionate and transparent communication, and practical guidance for the future. These principles are part of palliative care, a field of medicine focused on alleviating suffering in patients with serious, chronic illness. Clinicians involved in the care of patients with CNS tumors must be educated in these important primary palliative care principles. This article focuses on key symptom management, strategies for high-quality communication, a discussion of advance care planning, and an overview of end-of-life care.
Neurologic Complications of Conventional Chemotherapy and Radiation Therapy
Authors: Taylor Jennie W. 
Published: December 2023

ABSTRACT

OBJECTIVE
Neurologic complications are among the most common and feared outcomes of cancer treatments. This review discusses the signs and symptoms, mechanisms, and management of the most common peripheral and central neurologic complications of chemotherapy, radiation therapy, and antiangiogenic therapy during cancer treatment and in survivors.

LATEST DEVELOPMENTS
The landscape of cancer treatments is evolving to include more targeted and biologic therapies, in addition to more traditional cytotoxic therapies and radiation therapy. With increasingly complex regimens and longer survival for patients with cancer, the early recognition and management of neurologic complications is key to improving the morbidity and mortality of patients living with cancer.

ESSENTIAL POINTS
Neurologists should be familiar with acute central and peripheral toxicities that can occur during cancer treatment and delayed toxicities that can occur years after exposure. Neurologists should be familiar with the clinical and radiologic presentations of these complications and strategies for management.
Διδακτική παρέμβαση στο νηπιαγωγείο: «Το αλφαβητάρι του ονόματός
μου»
Authors: Τζήλου Γεωργία , Μακρή Κονδυλία 
Published: December 2023

Στην παρούσα εργασία παρουσιάζεται ο σχεδιασμός, η
πραγματοποίηση και η αξιολόγηση των αποτελεσμάτων μίας διδακτικής παρέμβασης, που
εκπονήθηκε σε δημόσιο νηπιαγωγείο, κατά το Α τρίμηνο του σχολικού έτους 2022-2023, στο
πλαίσιο της τάξης. Περιλαμβάνει μία σειρά από δραστηριότητες με στόχο
οι μαθητές κατά τη διαδικασία της μάθησης, παράλληλα με την ενδελεχή εξάσκησή τους στη
διατύπωση λόγου, να αναπτύξουν τη δημιουργικότητά τους και δεξιότητες κριτικής
σκέψης. Σκοπό έχει να βοηθήσει τα παιδιά αξιοποιώντας τα βασικά
εργαλεία του θεματικού πεδίου «Παιδί και Επικοινωνία», να γνωρίσουν τα γράμματα του
ονόματός τους και την τέχνη της βιβλιοδεσίας και μέσα από δημιουργική αναζήτηση και
σύνθεση απόψεων να παράγουν εκφραστικό και γραπτό λόγο, να εκφραστούν καλλιτεχνικά και να
εξοικειωθούν με τη δημιουργία βιβλίου-αλφαβηταρίου.
Μεσογειακή διατροφή: H ιδανική διατροφή για την καρδιά
Authors: Κάππου Μαρία 
Published: December 2023

Το άρθρο παρουσιάζει τα οφέλης της μεσογειακής διατροφής
και τον προστατευτικό της ρόλο στην πρόληψη και την αντιμετώπιση των καρδιαγγειακών
νοσημάτων.
Features of marketing in the pharmacological business in the postcovid period
Authors: Novikova Mariya 
Published: December 2023

Pharmaceutical marketing is an activity for the development, production and marketing of medicines based on a preliminary study of the needs of the pharmaceutical market.
The active development of the digitalization of the pharmaceutical market was given by 2020, it marked the beginning of remote trade in medicines, closer contacts of company representatives with medical professionals through videoconferences, an increase in e-mail newsletters, an explosive growth in the volume of advertising on the Internet, the development of native advertising.
Currently, promotion via the Internet plays a huge role, but the standard way of making a purchase decision remains. The buyer still goes through the stages of making a purchase: knowledge, interest, research, action, commitment. But the path from obtaining primary knowledge about the product to making a purchase becomes more difficult, since in addition to advertising, the recommendation of a doctor or pharmacist, the buyer studies the product using the Internet.