bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resequencing of the TMF-1 (TATA Element Modulatory Factor) regulated protein (TRNP1) gene in domestic and wild canids
Authors: Sacco James C. , Starr Emma , Weaver Alyssa , Dietz Rachel , Spocter Muhammad A. 
Published: November 2023

Abstract
Background
Cortical folding is related to the functional organization of the brain. The TMF-1 regulated protein (TRNP1) regulates the expansion and folding of the mammalian cerebral cortex, a process that may have been accelerated by the domestication of dogs. The objectives of this study were to sequence the TRNP1 gene in dogs and related canid species, provide evidence of its expression in dog brain and compare the genetic variation within dogs and across the Canidae. The gene was located in silico to dog chromosome 2. The sequence was experimentally confirmed by amplifying and sequencing the TRNP1 exonic and promoter regions in 72 canids (36 purebred dogs, 20 Gy wolves and wolf-dog hybrids, 10 coyotes, 5 red foxes and 1 Gy fox).

Results
A partial TRNP1 transcript was isolated from several regions in the dog brain. Thirty genetic polymorphisms were found in the Canis sp. with 17 common to both dogs and wolves, and only one unique to dogs. Seven polymorphisms were observed only in coyotes. An additional 9 variants were seen in red foxes. Dogs were the least genetically diverse. Several polymorphisms in the promoter and 3'untranslated region were predicted to alter TRNP1 function by interfering with the binding of transcriptional repressors and miRNAs expressed in neural precursors. A c.259_264 deletion variant that encodes a polyalanine expansion was polymorphic in all species studied except for dogs. A stretch of 15 nucleotides that is found in other mammalian sequences (corresponding to 5 amino acids located between Pro58 and Ala59 in the putative dog protein) was absent from the TRNP1 sequences of all 5 canid species sequenced. Both of these aforementioned coding sequence variations were predicted to affect the formation of alpha helices in the disordered region of the TRNP1 protein.

Conclusions
Potentially functionally important polymorphisms in the TRNP1 gene are found within and across various Canis species as well as the red fox, and unique differences in protein structure have evolved and been conserved in the Canidae compared to all other mammalian species.
Evaluation of the collapsible deformation of surrounding rock of loess hydraulic tunnel considering ground stress variation
Authors: Fangtao She , Wanying Xu , Lele Liu , Guoping Liu , Lei Li , Changhui Duan 
Published: November 2023

Abstract
Background
Uneven settlement will occur as a result of the collapsible deformation of the loess strata, and the hydraulic tunnel lining structure will also fail. In this work, laterally confined compression tests were carried out on loess and the double-line method was employed to evaluate the loess collapsibility. The deformation of the surrounding rock of a loess hydraulic tunnel under various ground stresses and its effect on the lining structure was modeled.

Results
Three stages were noted in the collapsible deformation of loess. The critical point between the former two stages corresponds to the pre-consolidation pressure of saturated loess and that between the latter two is taken as the structural yield pressure of unsaturated loess.

Conclusion
From the relationship between the collapsibility coefficient and vertical stress, the deformation of the tunnel under ground seepage primarily originates from two sources, i.e., the collapsible and compressive deformation. The latter source accounts for the deformation of loess adjacent to the lining when the seepage depth is low, while both sources are included when the bottom of the tunnel invert is infiltrated. The collapsible deformation is lower than that of the original stratum due to the stress relaxation during tunnel excavation. The tensile and compressive stresses of tunnel lining increase linearly with the seepage depth, with the maximum appearing at a position of 20 m away from the midline of the collapse and non-collapse domains. The results will provide a theoretical reference to the design and construction of hydraulic tunnels in collapsible loess stratum.
In situ anchoring iron oxide nanoparticles onto polyester/disperse dye for production of multifunctional fabrics
Authors: Abou Elmaaty Tarek , Abd Elsalam Sherif , Helal Shaimaa , Abdeldayem Shereen A. 
Published: November 2023

AbstractMedical textiles, including surgical gowns, masks are used as obstacles to prevent the risk of infection for both doctor and patient. The widespread of bacteria and viruses, e.g. chronic hepatitis B, hepatitis C and currently Covid-19 viruses in the patient population is very common. In this work, multifunctional eco-friendly polyester fabrics have been produced by in situ impregnation of 2-((E)-(2-(2,4-dinitrophenyl)hydrazono)methyl)-4-((E)-phenyldiazenyl)phenol disperse dye onto magnetic iron oxide nanoparticles. The technique endowed polyester fabrics with a new color as well as magnetic and antibacterial functionalities. The colored magnetic nanoparticles showed high affinity toward fabrics. Besides, the unbound dye could be easily collected from wastewater by a magnet, significantly facilitate the wastewater treatment. The treated fabrics were analyzed by energy dispersive X-ray spectroscopy, scanning electron microscopy, X-ray diffraction and vibrating sample magnetometry. Colorimetric values, tensile properties and fastness of the composite fabrics were also measured. The tensile properties of the composite were increased after functionalization. The wettability features of the fabric were investigated and showed a significant improvement. Also, the toxicity of the resulted fabric was exhibited low toxicity against wi-38 cell line. These results indicate the potentiality of the suggested technique in producing multifunctional fabrics with various applications, especially as medical textiles.
Sodium zirconium cyclosilicate hydrate reduces medical expenses compared with hemodialysis in patients with acute hyperkalemia
Authors: Fujioka Hayato , Imamura Teruhiko , Koike Tsutomu , Yokoyama Shingo , Kakeshita Kota , Yamazaki Hidenori , Kinugawa Koichiro 
Published: November 2023

Abstract
Background
Sodium zirconium cyclosilicate (SZC) has recently emerged as a therapeutic option for the management of acute hyperkalemia. Nevertheless, the relative effectiveness, safety, and financial considerations of SZC therapy versus conventional hemodialysis therapy remain uncertain.

Methods
In this retrospective study, we embarked upon a comparative analysis encompassing the financial aspects, safety profiles, and efficacy metrics associated with SZC therapy and hemodialysis in patients grappling with acute hyperkalemia. No patients had systemic congestion or uremia.

Results
A total of 21 patients (median 81 years old, 14 men) were included; 14 received SZC therapy and seven underwent hemodialysis. Acute hyperkalemia improved immediately within several days without any procedure-related adverse events, regardless of therapeutic interventions (p < 0.05 for both). Total medical expenses were significantly lower in the SZC group than in the hemodialysis group (55,596 [43,652, 69,761] vs. 419,768 [354,270, 514,700] Japanese yen, p < 0.001).

Conclusions
In the realm of acute hyperkalemia management, SZC therapy emerges as an economically judicious alternative, while upholding parity in terms of safety and effectiveness when compared with the conventional hemodialysis paradigm—unless complicated by systemic congestion or uremia. The pressing task at hand revolves around the discernment of the optimal patient demographic for SZC therapy within the ambit of acute hyperkalemia.
The AANS Harvey Cushing Medal: a demographic and academic analysis of its recipients
Authors: Pierre Kevin , Bardhi Olgert , Laurent Dimitri , Vaziri Sasha , Lucke-Wold Brandon , Brennan Meghan M. , Dagra Abeer , Olowofela Bankole , Barthélemy Ernest 
Published: November 2023

Abstract
Background
The Harvey Cushing Medal, awarded by the American Association of Neurological Surgeons, is the premier accolade in neurosurgery. The study’s purpose was to examine the qualities and accomplishments of previous winners, emphasizing potential selection biases, with the aim to promote social justice and guide young neurosurgeons in their career paths.

Results
Predominantly, recipients graduated from top-ranked United States News and World Report institutions and specialized in cerebrovascular and neuro-oncologic/skull base neurosurgery. A significant proportion held roles as department or division chairs and led neurosurgical organizations. All awardees were male, and there was a notable trend of increasing publication counts among more recent recipients.

Conclusions
Commonalities among Harvey Cushing Medal winners include graduating from top institutions, holding significant leadership roles, and having an extensive publication history. However, the absence of female and underrepresented minority awardees underscores an urgent need for greater diversity in the selection process.
Schizophrenia and family burden in Morocco: assessment in a sample of 150 caregivers
Authors: Benallel Khadija , Sabah Meryem Sara Zineb , Otheman Yassine , Kadiri Mohamed 
Published: November 2023

Abstract
Background
There have been few studies conducted in Africa about the burden on families of patients with schizophrenia. This study had two main objectives: assessing the burden of those families and identifying the socio-demographic factors associated with this one.

Methods
We included 300 participants: 150 were primary family caregivers of 150 patients with schizophrenia. A questionnaire was used to collect their sociodemographic and clinical characteristics, and their objective burden using the FBIS (Family Burden Interview Schedule).

Results
Patients were mostly men (n = 122, 81%), the mean age was 32.4 years ± 10.1, and more than half of the patients were psychoactive substance users. Participants (caregivers) were mostly women (n = 90, 60%). Their mean age was 51.9 ± 12.8 years, with a percentage of 62 (41%) illiteracy, while 98 (65%) were parents. The mean score of the family burden was 21.82 (0–48). The most affected categories were family routine, family interaction, and finances. The burden of families was associated with five sociodemographic variables: the female gender of the caregiver (p = 0.01), the male gender of the patient (p = 0.02), his young age (p = 0,004), his education level (p < 0.0001), and his psychoactive substance use (PAS) (p < 0.000 1).

Conclusion
The three main constraints encountered by families caring for a patient with schizophrenia were disruption of daily activities, deterioration in the quality of family interactions with those around them, and lastly financial difficulties. These results highlighted the need to set up intermediary socio-medical structures, which would act as a link between conventional hospital services and families.
Exploring visitors’ visual perception along the spatial sequence in temple heritage spaces by quantitative GIS methods: a case study of the Daming Temple, Yangzhou City, China
Authors: Zhou Kai , Wu Wenting , Li Tianjie , Dai Xiaoling 
Published: November 2023

AbstractThe Daming Temple, built during 457–464 C.E., is one of the developing ancient temple heritage spaces located in Yangzhou city, P. R. China. Over the past 60 years, variation in visitors’ spatial perception along the tour routes in the temple has occurred. This research attempts to reveal the changes in visitors’ visual perception along the spatial sequences at 3 different times (i.e., 1962, 1973 and 2022). A quantitative GIS-based method, which includes analysing the distribution of visitors’ spatial preferences and spatial configuration, is proposed. Digital landscape tools and quantitative estimation methods are used, including mapping within Rhinoceros software, the kernel density estimation (KDE) method within ArcGIS software and spatial syntax analysis within DepthMap software. Extracted geodata from 500 photographs of the heritage space taken by volunteer visitors are analysed within the GIS environment. Values of the mean depth (MD) at both levels of visibility and accessibility are calculated within the visibility graph analysis (VGA) model. Comparisons between the visual preferences of the visitors and the spatial configuration along the spatial sequence are conducted. The results indicate that the spatial sequence has a significant impact on visitors’ visual preferences and tour routes. The phenomenon of spatial sequence among dynamic temporal variations and the effects of narrative spaces along the spatial sequence are highlighted and explained, which reveal the relationship between visitors’ geospatial preference and the spatial configuration of the temple. Some suggestions are put forwards for further studies on the revitalisation and management of East Asian ancient temple heritage spaces.
Psychotic and autistic traits among magicians and their relationship with creative beliefs
Authors: Greengross Gil , Silvia Paul J. , Crasson Sara J. 
Published: November 2023

Background
There is a common perception that creativity is associated with psychopathology. Previous studies have shown that members of creative groups such as comedians, artists and scientists scores higher than the norm on psychotic traits, and scientists in STEM (science, technology, engineering and mathematics) fields score highly on autistic traits.

Aims
To test whether magicians, a creative group that has not been studied before, also score highly on psychopathological traits and autism, and to test the associations of creative self-efficacy and creative identity with schizotypal and autistic traits among magicians.

Method
A sample of 195 magicians and 233 people from the general population completed measures of schizotypal traits (Oxford–Liverpool Inventory of Feelings and Experiences) and autism (Abridged Version of the Autism-Spectrum Quotient), as well as the Short Scale of Creative Self. Magicians were also compared with other creative groups with respect to schizotypal traits, based on previously published data.

Results
Magicians scored lower than the general population sample on three of the four schizophrenia measures (cognitive disorganisation, introvertive anhedonia and impulsive nonconformity) but did not differ with respect to unusual experiences or autism scores. Magicians scored higher on creative self-efficacy and creative personal identity than the general sample. Magicians’ scores on schizotypal traits were largely lower than those of other creative groups. Originality of magic was positively correlated with unusual experiences (r = 0.208), creative self-efficacy (r = 0.251) and creative identity (r = 0.362).

Conclusions
This is the first study to show a creative group with lower scores than norms on psychotic traits. The results highlight the unique characteristics of magicians and the possible myriad associations between creativity and mental disorders among creative groups.
Efficacy and safety of laparoscopic vs open gastrectomy after neoadjuvant therapy for locally advanced gastric cancer
Authors: Yu Chang-Da , Zhang Ke 
Published: November 2023

BACKGROUND
Laparoscopic gastrectomy (LG) is widely accepted as a minimally invasive approach for the treatment of early gastric cancer. However, its role in locally advanced gastric cancer (LAGC) after neoadjuvant therapy (NAT) remains controversial. This study aimed to compare the efficacy and safety of LG vs open gastrectomy (OG) after NAT for the treatment of LAGC.
AIM
To compare the efficacy and safety of LG vs OG after NAT for LAGC.
METHODS
We conducted a prospective study of 76 patients with LAGC who underwent NAT followed by LG (n = 38) or OG (n = 38) between 2021 and 2023. The primary endpoint was overall survival (OS), and the secondary endpoints were disease-free survival (DFS), surgical complications, and quality of life (QOL).
RESULTS
The two groups had comparable baseline characteristics, with a median follow-up period of 24 mo. The 3-year OS rates in the LG and OG groups were 68.4% and 60.5%, respectively (P = 0.42). The 3-year DFS rates in the LG and OG groups were 57.9% and 50.0%, respectively (P = 0.51). The LG group had significantly less blood loss (P < 0.001), a shorter hospital stay (P < 0.001), and a lower incidence of surgical site infection (P = 0.04) than the OG group. There were no significant differences in other surgical complications between the groups, including anastomotic leakage, intra-abdominal abscess, or wound dehiscence. The LG group had significantly better QOL scores than the OG group regarding physical functioning, role functioning, global health status, fatigue, pain, appetite loss, and body image at 6 months postoperatively (P < 0.05).
CONCLUSION
LG after NAT is a viable and safe alternative to OG for the treatment of LAGC, with similar survival outcomes and superior short-term recovery and QOL. LG patients had less blood loss, shorter hospitalizations, and a lower incidence of surgical site infections than OG patients. Moreover, the LG group had better QOL scores in multiple domains 6 mo postoperatively. Therefore, LG should be considered a valid option for patients with LAGC who undergo NAT, particularly for those who prioritize postoperative recovery and QOL.
Efficacy and safety of aspirin antiplatelet therapy within 48 h of symptom onset in patients with acute stroke
Authors: Zhang Jian-Quan , Pan Zhi-Bin 
Published: November 2023

BACKGROUND
Aspirin is a widely used antiplatelet agent that reduces the risk of recurrent ischemic stroke and other vascular events. However, the optimal timing and dose of aspirin initiation after an acute stroke remain controversial.
AIM
To evaluate the efficacy and safety of aspirin antiplatelet therapy within 48 h of symptom onset in patients with acute stroke.
METHODS
We conducted a randomized, open-label, controlled trial in 60 patients with acute ischemic or hemorrhagic stroke who were admitted to our hospital within 24 h of symptom onset. Patients were randomly assigned to receive either aspirin 300 mg daily or no aspirin within 48 h of stroke onset. The primary outcome was the occurrence of recurrent stroke, myocardial infarction, or vascular death within 90 d. The secondary outcomes were functional outcomes at 90 d measured using the modified Rankin Scale (mRS), incidence of bleeding complications, and mortality rate.
RESULTS
The mean age of the patients was 67.8 years and 55% of them were male. The median time from stroke onset to randomization was 12 h. The baseline characteristics were well balanced between the two groups. The primary outcome occurred in 6.7% of patients in the aspirin group and 16.7% of patients in the no aspirin group (relative risk = 0.40, 95% confidence interval: 0.12-1.31, P = 0.13). The mRS score at 90 d was significantly lower in the aspirin group than in the no aspirin group (median, 2 vs 3, respectively; P = 0.04). The incidence of bleeding complications was similar between the groups (6.7% vs 6.7%, P = 1.00). The mortality rates were also comparable between the two groups (10% vs 13.3%, P = 0.69).
CONCLUSION
Aspirin use is associated with favorable functional outcomes but does not significantly reduce the risk of recurrent vascular events. Its acceptable safety profile is comparable to that of no aspirin. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.
Intracranial infection accompanied sweet’s syndrome in a patient with anti-interferon-γ autoantibodies: A case report
Authors: Zheng Jun-Hui , Wu Dan , Guo Xiao-Yun 
Published: November 2023

BACKGROUND
Several reports of adult-onset immunodeficiency syndrome have been associated with anti-interferon-gamma (IFN-γ) autoantibodies (AIGAs). However, it is rare to find AIGAs with intracranial infections.
CASE SUMMARY
In this case study, we report a case of an AIGAs with intracranial infection and hand rashes considered Sweet’s syndrome. The patient presented to our hospital with a persistent cough, a fever that had been going on for 6 mo, and a rash that had been going on for a week. The patient started losing consciousness gradually on the fourth day after admission, with neck stiffness and weakened limb muscles. The upper lobe of the left lung had a high-density mass with no atypia and a few inflammatory cells in the interstitium. Brain magnetic resonance imaging and cerebrospinal fluid suggest intracranial infection. The pathology of the skin damage on the right upper extremity revealed an infectious lesion that was susceptible to Sweet’s disease. It has an anti-IFN-γ autoantibody titer of 1:2500. She was given empirical anti-non-tuberculous mycobacterial and antifungal treatments. The patient had no fever, obvious cough, headache, or rash on the hand. She got out of bed and took care of herself following hospitalization and discharge with medicine.
CONCLUSION
Adults with severe and recurrent infections of several organs should be considered for AIGAs if no other known risk factors exist. AIGAs are susceptible to subsequent intracranial infections and Sweet’s syndrome.
Inorganic Carbon-Limited Freshwater Algal Growth at High Ph: Revisited with Focus on Alkalinity
Authors: Watson Mary Katherine , Flanagan Elizabeth , Drapcho Caye M. 
Published: November 2023

Highlights

Non-carbonate components of BG11 media impact TIC calculation on average 4.00 mg/L at high pH.

BG11 media non-carbonate alkalinity (NCA) varies with pH: NCA (meq/L) = 0.0393×e0.2075×pH + (2.086×10-9)e1.860×pH.

Monod kinetic constants with CO2, HCO3
-, and CO3
2- as inorganic carbon sources are improved from a previous report.

Kinetic constants continue to be the only known reports considering multiple inorganic carbon sources.

Algal stoichiometric reactions are developed that account for variation in cell content and carbon source.

Abstract. Due to increasing atmospheric CO2, algal growth systems at high pH are of interest to support enhanced diffusion and carbon capture. Given the interactions between algal growth, pH, and alkalinity, data from Watson and Drapcho (2016) were re-examined to determine the impact of the non-carbonate constituents in BG11 media on estimates of Monod kinetic parameters, biomass yield, and cell stoichiometry. Based on a computational method, non-carbonate alkalinity (NCA) in BG11 media varies with pH according to: NCA (meq/L) = 0.0393×e0.2075×pH + (2.086×10-9)e1.860×pH (R2 = 0.999) over the pH range of 10.3 – 11.5. Updated maximum specific growth rates were determined to be 0.060, 0.057, and 0.051 hr-1 for CO2, HCO3, and CO3, respectively. Generalizable stoichiometric algal growth equations that consider variable nutrient ratios and multiple inorganic carbon species were developed. Improved kinetic and stoichiometric parameters will serve as the foundation for a dynamic mathematical model to support the design of high pH algal carbon capture systems. Keywords: Algae, Alkalinity, Carbon Abatement, Carbon Capture, Kinetics, Stoichiometry, Total Inorganic Carbon.
Structural stability design of an optical mirror mount adjustment mechanism
Authors: Dong Ziming , Zhu Jianqiang , Liu Zhigang , Fan Wei , Sun Ziming , Zhang Donghui , Zhang Chao , Zhang Kaiqi 
Published: November 2023

The stability of beam pointing in a laser system depends on the consistency of the optical mirror mount. Typically, a locking mechanism is used to secure the adjustment mechanism after beam alignment, ensuring the mount’s stability. However, this process can introduce errors, causing a drift in the optical path. To mitigate this issue, in this study, an interference fit adjustment screw was designed. This development enables the mechanism to self-lock after beam alignment, thereby preventing optical path drift and enhancing overall stability. Specifically, 14 long-term thermal shock stability tests, each lasting 2500 min, were conducted to validate the proposed design. The experimental results showed that the thermal drift of the interference fit adjustment screw was reduced by 47.16%, thermal shift was reduced by 79.59%, and the long-term stability improved by at least 48.67%.