bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterologous expression of the human wild‐type and variant NaV1.8 (A1073V) in rat sensory neurons
Authors: Kapur Maryam M. , Soliman Marwa , Blanke Emily N. , Herold Paul B. , Janicki Piotr K. , Vrana Kent E. , Coates Matthew D. , Ruiz‐Velasco Victor 
Published: January 2024

AbstractBackgroundSilent inflammatory bowel disease (IBD) is a condition in which individuals with the active disease experience minor to no pain. Voltage‐gated Na+ (NaV) channels expressed in sensory neurons play a major role in pain perception. Previously, we reported that a NaV1.8 genetic polymorphism (A1073V, rs6795970) was more common in a cohort of silent IBD patients. The expression of this variant (1073V) in rat sympathetic neurons activated at more depolarized potentials when compared to the more common variant (1073A). In this study, we investigated whether expression of either NaV1.8 variant in rat sensory neurons would exhibit different biophysical characteristics than previously observed in sympathetic neurons.MethodsEndogenous NaV1.8 channels were first silenced in DRG neurons and then either 1073A or 1073V human NaV1.8 cDNA constructs were transfected. NaV1.8 currents were recorded with the whole‐cell patch‐clamp technique.Key ResultsThe results indicate that 1073A and 1073V NaV1.8 channels exhibited similar activation values. However, the slope factor (k) for activation determined for this same group of neurons decreased by 5 mV, suggesting an increase in voltage sensitivity. Comparison of inactivation parameters indicated that 1073V channels were shifted to more depolarized potentials than 1073A‐expressing neurons, imparting a proexcitatory characteristic.Conclusions and InferencesThese findings differ from previous observations in other expression models and underscore the challenges with heterologous expression systems. Therefore, the use of human sensory neurons derived from induced pluripotent stem cells may help address these inconsistencies and better determine the effect of the polymorphism present in IBD patients.
Effectiveness of promethazine on preoperative and intraoperative sequelae in cleft palate surgeries
Authors: Vedha Vivigdha A. , Senthil Murugan P. , Santhosh Kumar M. P. , Khuntia Sibasish 
Published: January 2024

AbstractIntroductionAnxiety and nosocomial infection are the most common reported problems in children undergoing cleft surgeries. Research shows that there is an enigma in the use of antihistamine therapy in children for the management of upper respiratory tract infection. ‘Promethazine’ is a first‐generation H1 receptor antagonist, and antihistamine also has strong sedative effects. Our study aims at evaluating the Effectiveness of Promethazine (Phenergan) in preoperative and intra operative sequelae in cleft surgeries.Materials and MethodsThis is a single‐centre, parallel, randomized, double‐blinded randomized control clinical trial, which was conducted among 128 children between 2 and 4 years of age undergoing cleft palate surgery under general anaesthesia. After randomization, the case group was subjected to promethazine syrup 1 mg/kg body weight twice a day, orally for 3 days. The primary outcomes were preoperative anxiety levels which were recorded by children fear scale. The secondary outcomes include preoperative sleep quality and cough rate of children which are recorded by using sleep and cough objective scale respectively. The intraoperative heart rate is monitored with an ECG connected to a monitor.ResultsPromethazine causes a reduction in the anxiety level by 70%, 64% reduction in cold and cough, improvement in sleep score by 70% and the heart rate was found to be stable throughout the surgery when compared to the control group.ConclusionAs the benefits of promethazine in cleft palate surgery rule over its adverse effects, promethazine is considered safe to be used as premedication for children undergoing cleft palate surgeries.
Late recurrence of calcifying odontogenic cyst: Report of a rare case and review of the literature
Authors: Tamiolakis Paris , Georgaki Maria , Christopoulos Panagiotis , Nikitakis Nikolaos G. 
Published: January 2024

AbstractCalcifying odontogenic cyst (COC) is a relatively uncommon cyst of odontogenic origin, occurring in the second decade of life, with no jaw predilection. Radiographically, it typically appears as a well‐defined unilocular radiolucency containing irregular calcifications of varying size and opacity. Treatment consists of conservative surgical excisions with low recurrence rates. The purpose of this paper is to report a rare case of late COC recurrence and review the pertinent literature. A 42‐year‐old female patient presented for evaluation of a painless swelling in the palate, which had been present for 5 years with a gradual, slow increase in dimensions. Twenty years before, a lesion at the same site was surgically excised with a diagnosis of COC. Clinical examination revealed a hard‐in‐consistency swelling in the anterior segment of the hard palate. Radiographically, a radiopaque lesion with an irregular outline was noticed in the left palate adjacent to the left maxillary canine and first premolar, along with a well‐defined radiolucent lesion between the maxillary central incisors. Both lesions were surgically excised, and histopathological examination revealed that the main lesion in the left palate was consistent with recurrent COC, while the lesion between the central incisors was compatible with a nasopalatine duct cyst. Even though the recurrence rate of COC is low, estimated at 3.4% based on our review of the relevant English‐language literature, the current case highlights the possibility of a late recurrence, even several years after the initial diagnosis and treatment, and therefore the need for long‐term follow‐up.
Upgrade from leadless to transvenous pacemaker with left bundle branch area pacing: A case report
Authors: Palmisano Pietro , Parlavecchio Antonio , Guido Alessandro , Accogli Michele , Coluccia Giovanni 
Published: January 2024

AbstractAn 80‐years‐old patient with permanent atrial fibrillation and symptomatic, paroxysmal atrioventricular blocks (AVBs) underwent leadless pacemaker (L‐PM) implantation. Seven years after implantation, as a consequence of a progression of the AVB towards a persistent form, resulting in an increased need for pacing, he developed a pacing‐induced cardiomyopathy. He then underwent a successful upgrade from L‐PM to a transvenous pacemaker (T‐PM) with left bundle branch area pacing (LBBAP). The L‐PM did not interfere with the T‐PM and was turned off and abandoned. One month after the upgrading the patient showed a significant improvement in cardiac function and functional capacity.
Where have all the pediatric anesthesiology fellows gone in the USA? Anesthesiology fellowship trends
Authors: Giustini Andrew J. , Sivak Erica L. , Nasr Viviane G. , Cladis Franklyn P. , Andropoulos Dean B. , Deutsch Nina , Lockman Justin L. , Bower Bree , Corridore Marco , Muffly Matthew K. 
Published: January 2024

AbstractBackgroundRecent consternation over the number of unfilled Pediatric Anesthesiology fellowship positions in the United States compelled us to assess the change in the ratio of Pediatric Anesthesiology fellows to the number of graduating anesthesiology residents over the 14‐year period between 2008 and 2022. We also sought to report the total ratio of anesthesiology fellows to graduating residents and trends in the annual number of fellowship applicants relative to the number of Accreditation Council for Graduate Medical Education (ACGME)‐accredited anesthesiology fellowship positions by specialty.MethodsWe used publicly available resources, including ACGME Data Resource Books, National Resident Matching Program (NRMP) data, San Francisco (SF) Match data, and American Board of Medical Specialties (ABMS) data, to determine the ratio of anesthesiology fellows to graduating anesthesiology residents and to compare the number of fellowship applicants to fellowship positions for Adult Cardiothoracic Anesthesiology, Critical Care Anesthesiology, Obstetric Anesthesiology, Pain Medicine and Pediatric Anesthesiology.ResultsSince 2008, the ratio of ACGME‐accredited anesthesiology fellows to graduating residents increased from 0.36 in 2008 (2007 residency graduates) to 0.59 in 2022 (2021 residency graduates) and the ratio of Pediatric Anesthesiology fellows to graduating residents remained relatively stable from 0.10 to 0.11. The number of unmatched positions in Pediatric Anesthesiology increased from 17 in 2017 to 86 in 2023, and all ACGME‐accredited fellowships had more positions available than applicants in 2023.ConclusionIn the USA, while the ratio of Pediatric Anesthesiology fellowship graduates to anesthesiology residency graduates remained relatively constant from 2008 to 2022, this is likely a lagging indicator that has not yet accounted for the recent decrease in fellowship applicants. These findings refute prior estimates for a surplus in Pediatric Anesthesia supply in the USA and have significant implications for the future.
Live‐attenuated vaccination for measles, mumps, and rubella in pediatric liver transplantation
Authors: Keutler Anne , Lainka Elke , Posovszky Carsten 
Published: January 2024

AbstractBackgroundInfections are a serious short‐ and long‐term problem after pediatric organ transplantation. In immunocompromised patients, they can lead to transplant rejection or a severe course with a sometimes fatal outcome. Vaccination is an appropriate means of reducing morbidity and mortality caused by vaccine‐preventable diseases. Unfortunately, due to the disease or its course, it is not always possible to establish adequate vaccine protection against live‐attenuated viral vaccines (LAVVs) prior to transplantation. LAVVs such as measles, mumps, and rubella (MMR) are still contraindicated in solid organ transplant recipients receiving immunosuppressive therapy (IST), thus creating a dilemma.AimThis review discusses whether, when, and how live‐attenuated MMR vaccines can be administered effectively and safely to pediatric liver transplant recipients based on the available data.Material and MethodsWe searched PubMed for literature on live‐attenuated MMR vaccination in pediatric liver transplantation (LT).ResultsNine prospective observational studies and three retrospective case series were identified in which at least 833 doses of measles vaccine were administered to 716 liver transplant children receiving IST. In these selected patients, MMR vaccination was well tolerated and no serious adverse reactions to the vaccine were observed. In addition, an immune response to the vaccine was demonstrated in patients receiving IST.ConclusionDue to inadequate vaccine protection in this high‐risk group, maximum efforts must be made to ensure full immunization. MMR vaccination could also be considered for unprotected patients after LT receiving IST following an individual risk assessment, as severe harm from live vaccines after liver transplantation has been reported only very rarely. To this end, it is important to establish standardized and simple criteria for the selection of suitable patients and the administration of the MMR vaccine to ensure safe use.
Policy feedback, varieties of federalism, and the politics of health‐care funding in the United States, Mexico, and Canada
Authors: Béland Daniel , Marchildon Gregory P. , Medrano Anahely , Rocco Philip 
Published: January 2024

AbstractLong before the COVID‐19 pandemic, health‐care spending became a key policy issue across the OECD. Comparing recent institutional trends in public health‐care financing in three federal countries—Canada, the United States, and Mexico—this article explores the political struggles over fiscal federalism in health care related to both vertical and horizontal imbalances that can generate regional tensions and pit subnational governments against one another and, especially, against the national government. Grounded in a historical institutionalist perspective, the article shows how different institutional legacies shape current conflicts over federal health‐care funding in these three highly dissimilar federal countries. Such an analysis stresses the role of policy feedback in social politics and the enduring “varieties of federalism” in North American public health‐care funding. More specifically, the article shows how the distinct nature of policy feedback effects in the United States, Mexico, and Canada helps explain why the two former countries recently witnessed major changes in intergovernmental relations over fiscal federalism for health care while the latter did not.Related ArticlesBode, Ingo, and Jorge E. Culebro Moreno. 2018. “Paradoxical Internationalization: Regulatory Reforms in the Mexican Health‐Care System through the Lens of European Experience.” Politics & Policy 46(4): 678–710. https://doi.org/10.1111/polp.12268.Lauby, Fanny, and Christopher J. McKinley. 2023. “Factors of Early COVID‐19 Prevention Policy Engagement in France and the United States.” Politics & Policy 51(5): 830–48. https://doi.org/10.1111/polp.12556.Luccisano, Lucy, and Amy Romagnoli. 2007. “Comparing Public Social Provision and Citizenship in the United States, Canada, and Mexico: Are There Implications for a North American Space?” Politics & Policy 35(4): 716–51. https://doi.org/10.1111/j.1747‐1346.2007.00082.x.
Incidence of depression among community‐dwelling older adults: A systematic review
Authors: Brasileiro L.E.E. , Dantas Amanda Almeida Gomes , Linhares Dorothy Bezerra , Vale Heron Alves , Terradas‐Monllor Marc , Ochandorena‐Acha Mirari , Paiva Aílla Lorenna de Medeiros , de Medeiros Maria Yasmin Dantas , Jerez‐Roig Javier , de Souza Dyego Leandro Bezerra 
Published: January 2024

AbstractWe aimed to synthesise information related to the incidence of depression and depressive symptoms (DDS) in a community‐dwelling older adult population at a global level. In this systematic review, we included articles with a cohort study design that evaluated the incidence of depression or depressive symptoms in older adults aged 60 years or more in a community‐dwelling environment. Six databases were used: Web of Science, PubMed, Scopus, LILACS, SciELO, and Cochrane, and the entire selection process was independently performed by peers. We divided the included articles into subgroups according to the DDS assessment instrument: (i) Geriatric Depression Scale; (ii) Center for Epidemiologic Studies Depression Scale; (iii) miscellaneous scales; and (iv) diagnostic interviews. Each cumulative incidence value obtained per item was adjusted for a 1‐year follow‐up period, which generated an annual cumulative incidence (AcI). From 46 articles, 42 used scales to evaluate the depressive variable, with an AcI estimate of around 4.5%. The articles that assessed depression categorically observed a variation in AcI between 0.2% and 7.0%. Among all the materials included, the group that used the Geriatric Depression Scale observed the lowest and the highest AcI, 1.3% and 26.6% respectively. Most of the productions were from countries in the Asian continent (52.2%), followed by Europe (30.4%), the Americas (13%), and Oceania (4.4%). Despite the variation of AcI, we found a frequent occurrence of DDS in older adults in the community‐dwelling environment, which highlights the need for preventive actions and better‐targeted early care, especially in terms of primary health care.
“Homophobia” in the Country? Rural America and the Stigmatization ofLGBTQPeople: An Empirical Test of Norm‐Centered Stigma Theory
Authors: Worthen Meredith G. F. , Jones Melissa S. 
Published: January 2024

AbstractIn‐depth explorations of LGBTQ attitudes among rural Americans are sparse and often rely upon sweeping stereotypes that cluster all perspectives into one broad statement such as “homophobia” in the country. As a result, little is known about the relationships between rurality and the stigmatization of LGBTQ people. In addition, though research demonstrates that men are less supportive of LGBTQ people than women are, these patterns are unclear among rural Americans. In the current study, data from a sample of U.S. adults aged 18–64 stratified by the U.S. census categories of age, gender, race/ethnicity, and census region collected from online panelists (N = 2,802,n = 492 rural Americans) are utilized to investigate the relationships between rurality and attitudes toward lesbian women, gay men, bisexual women, bisexual men, trans women, trans men, nonbinary people, queer women, and queer men. Specifically, we offer a test of Norm‐Centered Stigma Theory with a focus on hetero‐cis‐normativity and intersecting experiences with social power (gender identity: cis women and cis men) as they relate to rurality and LGBTQ attitudes. Findings indicate that hetero‐cis‐normativity, rurality, and being a cisgender man are all significantly related to the stigmatization of LGBTQ people. Implications are provided.
Prevalence of extra‐pulmonary tuberculosis in Africa: A systematic review and meta‐analysis
Authors: Hailu Semira , Hurst Cameron , Cyphers Griffin , Thottunkal Stefan , Harley David , Viney Kerri , Irwin Adam , Dean Judith , Nourse Clare 
Published: January 2024

AbstractObjectiveThe burden of extra‐pulmonary tuberculosis (EPTB) is not well quantified in TB endemic countries such as those in sub‐Saharan Africa. This study aimed to quantify that burden via a systematic review of the prevalence of EPTB in African countries.MethodsStudies were retrieved by searching five databases; 105 studies published between 1990 and 2023 were included. The studies described the prevalence of EPTB among the general population (4 studies), TB patients (68) and patients with other conditions, including HIV (15), meningitis (3), renal failure (3) and other comorbidities, some of which are cancer (12). Due to the low number of studies reporting EPTB in patients with conditions other than TB, the meta‐analysis was performed on studies reporting on EPTB among TB patients (68 studies). Meta‐analysis was performed on the 68 studies (271,073 participants) using a random‐effects model to estimate the pooled prevalence of EPTB. Meta‐regression was used to explore possible explanations for heterogeneity according to regions and time periods.ResultsThe pooled prevalence of EPTB among TB patients was 26% (95% CI 23–29%). There was substantial heterogeneity of prevalence for the five African regions. The Eastern region had the highest prevalence of 32% (95% CI 28–37%) and the lowest in Western Africa, 16% (95% CI 10–24%). There was no significant difference in the prevalence of EPTB between the 3 eleven‐year time periods.ConclusionsOur systematic review and meta‐analysis give insight into the burden of EPTB in Africa. This review could inform clinical and programmatic practices–a higher suspicion index for clinicians and more effort for better services. This could contribute to efforts aiming to end TB, which have historically been focused on PTB.Coordinated efforts that target both EPTB and PTB are needed.
Human Designers' Dynamic Confidence and Decision-Making When Working With More Than One Artificial Intelligence
Authors: Chong Leah , Kotovsky Kenneth , Cagan Jonathan 
Published: January 2024

Abstract
As artificial intelligence (AI) systems become increasingly capable of performing design tasks, they are expected to be deployed to assist human designers' decision-making in a greater variety of ways. For complex design problems such as those with multiple objectives, one AI may not always perform its expected accuracy due to the complexity of decision-making, and therefore, multiple AIs may be implemented to provide design suggestions. For such assistance to be productive, human designers must develop appropriate confidence in each AI and in themselves and accept or reject AI inputs accordingly. This work conducts a human subjects experiment to examine the development of a human designer's confidence in each AI and self-confidence throughout decision-making assisted by two AIs and how these confidences influence the decision to accept AI inputs. Major findings demonstrate severe decreases in a human designer's confidence especially when working with one or more low-performing AI teammates and/or receiving negative feedback. Additionally, a human designer's decision to accept AI suggestions depends on their self-confidence and confidence in one of the two AIs. Finally, an additional AI does not increase a human designer's likelihood of conforming to AI suggestions. Therefore, in comparison to a scenario with one AI, the results in this work caution against the implementation of an additional AI to AI-assisted decision-making scenarios. The insights also inform the design and management of human–AI teams to improve the outcome of AI-assisted decision-making.
Maximizing the Throwing Distance of Robotic Manipulators: An Optimization Approach
Authors: Gallant André , Gosselin Clément 
Published: January 2024

Abstract
Manipulators are increasingly being called upon to perform a wide range of tasks. This paper explores the maximal distance throwing task for robotic manipulators and shows that this characteristic can be incorporated in the kinematic design process. Indeed, knowing the maximum distance that a manipulator can throw objects is useful in determining the viability of certain throwing tasks it might be called upon to execute. This paper studies three optimization problems: optimizing the release state to maximize the throwing distance, optimizing the kinematic trajectory subject to position, velocity, acceleration, and jerk constraints, and finally optimizing the kinematic design of manipulators to maximize the workspace as well as the throwing distance. Three manipulator architectures are used as case studies for these optimizations: a planar RR, a spatial RRR, and a wrist-partitioned 6R manipulator.
Timing of Caffeine Ingestion Does Not Improve Three-Point Shooting Accuracy in College Basketball Players
Authors: Tan Zhi Sen , Sim Rachelle Yahn Yee , Kawabata Masato , Low Dorrain Yanwen , Wang Yulan , Burns Stephen F. 
Published: January 2024

This study investigated the effects of the timing of caffeine (3 mg/kg body mass) ingestion on three-point shooting accuracy and other performance parameters during a basketball exercise simulation test (BEST). Eighteen college basketball players (mean ± SD: age = 24.4 ± 1.5 years, height = 181.7 ± 9.5 cm, body mass = 80.9 ± 13.2 kg) underwent one familiarization trial and three main conditions in a randomized order: (a) placebo (maltodextrin) and placebo, (b) caffeine and placebo, and (c) placebo and caffeine. Participants ingested either the placebo or caffeine pill 75 and 15 min before performing four quarters of the BEST and a three-point shooting protocol. During each quarter, participants completed 16 rounds of the BEST and ten three-point shots. Vertical jump height, 6 m sprint timing, BEST completion timing, three-point shooting accuracy, heart rate, rate of perceived exertion, blood glucose, blood lactate, and psychological measures pertaining to performance were measured. The BEST completion timing differed among conditions (placebo and placebo = 26.4 ± 2.0 s, caffeine and placebo = 25.8 ± 2.0 s, placebo and caffeine = 25.9 ± 2.1 s; p = .031) but not three-point shooting accuracy (placebo and placebo = 12.33 ± 4.10; caffeine and placebo = 12.61 ± 2.81; placebo and caffeine = 11.67 ± 3.77; p = .648), vertical jump height, or sprint times. Manipulating ingestion timing of caffeine did not improve three-point shooting accuracy, vertical jump height, or 6 m sprint timings, but caffeine can improve performance times during simulated basketball exercise irrespective of ingestion timing.
Supplemental Material: Iron fertilization–induced deoxygenation of eastern equatorial Pacific Ocean intermediate waters during the Paleocene–Eocene thermal maximum
Authors: Jiang Xiaodong , Chou Yu-Min , Yao Weiqi , al. et 
Published: January 2024

<p>Appendix S1–S4, Figures S1–S5, and Tables S1 and S2, plus references. </p>