bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful return to work in anaesthesia after maternity leave: a qualitative study
Authors: Allen K. J. , Chiavaroli N. , Reid K. J. 
Published: January 2024

SummaryReturning to work after maternity leave poses significant challenges, with potential long‐term implications including decreased engagement or attrition of clinicians. Many quantitative studies have identified challenges and supports for women during pregnancy, maternity leave and re‐entry to clinical practice. This qualitative study explored the experiences of anaesthetists returning to clinical work after maternity leave, to identify influential factors with the aim of providing a framework to assist planning re‐entry. We conducted semi‐structured interviews with 15 anaesthetists. Attendees of a re‐entry programme were invited to participate, with purposive sampling and snowball recruitment to provide diversity of location and training stage, until data saturation was reached at 13 interviews. Five themes were identified: leave duration; planning re‐entry; workplace culture; career impact and emotional impact. Leave duration was influenced by concerns about deskilling, but shorter periods of leave had logistical challenges, including fatigue. Most participants started planning to return to work with few or no formal processes in the workplace. Workplace culture, including support for breastfeeding, was identified as valuable, but variable. Participants also experienced negative attitudes on re‐entry, including difficulty accessing permanent work, with potential career impacts. Many participants identified changes to professional and personal identity influencing the experience with emotional sequelae. This research describes factors which may be considered to assist clinicians returning to work after maternity leave and identifies challenges, including negative attitudes, which may pose significant barriers to women practising in anaesthesia and may contribute to lack of female leadership in some workplaces.
Pharmacokinetic of ceftazidime‐avibactam in a critically ill patient under high‐volume continuous venovenous haemodiafiltration: A first paediatric case report
Authors: Collignon Charlotte , Benaboud Sihem , Gana Inès , Bendavid Matthieu , Fournier Benjamin , Oualha Mehdi , de Marcellus Charles 
Published: January 2024

AbstractCeftazidime‐avibactam is a novel cephalosporin/B‐lactamase inhibitor developed in the context of increasing resistance. This case reports the pharmacokinetics of ceftazidime‐avibactam in a critically ill child under continuous renal replacement (CRRT) therapy for fluid overload. The patient was a 6‐month‐old female with sepsis due to bloodstream infection to Stenotrophomonas maltophilia following stem cell transplantation for severe combined immunodeficiency. CRRT was started on Day 2. Concentrations have been monitored using liquid chromatography–tandem mass spectrometry. Treatment was given every 8 h with a 2 h infusion of 30–7,5 mg/kg and did not reach pharmacokinetic/pharmacodynamic targets. Total clearance was respectively 1.7 and 3.02 L/h, with CRRT clearance respectively 28.8%–60% for ceftazidime and 14%–33% for avibactam. Those clearances are higher than reported in adult literature leading to a risk of treatment failure and emerging resistance. This supports the benefit of monitoring antimicrobial therapy under CRRT and the necessity to assess higher dosing or continuous infusion of ceftazidime‐avibactam.
Corporate social responsibility and tariff policy in a differentiated mixed duopoly
Authors: Wang Xingtang , Wang Leonard F. S. 
Published: January 2024

AbstractIn this paper, we assume that the domestic public firm competes in the market with a foreign private firm that cares about consumer surplus and the domestic government imposes tariffs on foreign firm. We aim to analyze the influence of the corporate social responsibility (CSR) level of foreign firm on privatization and tariff policy. It shows that if the government implements a privatization policy for the domestic public firm, the optimal degree of privatization decreases in the CSR level of foreign firm. Under the optimal privatization policy, if the product differentiation is relatively small, the equilibrium tariff increases in the CSR level; if the product differentiation is relatively large, the equilibrium tariff decreases in the CSR level; if the product differentiation is moderate, the relationship between the equilibrium tariff and CSR level is an inverted U‐shape. We further consider the policy implications under sequential moves of firms.
Influence of the bile acid/microbiota axis in ileal surgery: a systematic review
Authors: Senanayake Tharindu , Makanyengo Samwel , Hoedt Emily C. , Goggins Bridie , Smith Stephen R. , Keely Simon 
Published: January 2024

AbstractAimThe gastrointestinal bile acid (BA)/microbiota axis has emerged as a potential mediator of health and disease, particularly in relation to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer. Whilst it presents an exciting new avenue for therapies, it has not yet been characterized in surgical resection of the ileum, where BA reabsorption occurs. The identification of BA/microbiota signatures may provide future therapies with perioperative personalized medicine. In this work we conduct a systematic review with the aim of investigating the microbiome and BA changes that are associated with resection of the ileum.MethodThe databases included were MEDLINE, EMBASE, Web of Science and Cochrane libraries. The outcomes of interest were faecal microbiome and BA signatures after ileal resection.ResultsOf the initial 3106 articles, three studies met the inclusion/exclusion criteria for data extraction. A total of 257 patients (46% surgery, 54% nonsurgery controls) were included in the three studies. Two studies included patients with short bowel syndrome and the other included patients with IBD. Large‐scale microbiota changes were reported. In general, alpha diversity had decreased amongst patients with ileal surgery. Phylum‐level changes included decreased Bacteroidetes and increased Proteobacteria and Fusobacteria in patients with an intestinal resection. Surgery was associated with increased total faecal BAs, cholic acid and chenodeoxycholic acid. There were decreases in deoxycholic acid and glycine and taurine conjugated bile salts. Integrated BA and microbiota data identified correlations with several bacterial families and BA.ConclusionThe BA/microbiota axis is still a novel area with minimal observational data in surgery. Further mechanistic research is necessary to further explore this and identify its role in improving perioperative outcomes.
Development and pilot testing of a patient‐reported outcome measure to assess symptoms of parastomal hernia
Authors: Blazeby Jane M. , Murkin Charlotte , Rooshenas Leila , Elliott Daisy , Avery Kerry , Chalmers Katy , Cousins Sian , Pinkney Thomas , Blencowe Natalie , Reeves Barnaby C. , Smart Neil 
Published: January 2024

AbstractAimThe aim was to develop and pilot a patient‐reported outcome measure (PROM) to assess symptoms of parastomal hernia (PSH).MethodsStandard questionnaire development was undertaken (phases 1–3). An initial list of questionnaire domains was identified from validated colorectal cancer PROMs and from semi‐structured interviews with patients with a PSH and health professionals (phase 1). Domains were operationalized into items in a provisional questionnaire, and ‘think‐aloud’ patient interviews explored face validity and acceptability (phase 2). The updated questionnaire was piloted in patients with a stoma who had undergone colorectal surgery and had a computed tomography scan available for review. Patient‐reported symptoms were examined in relation to PSH (phase 3). Three sources determined PSH presence: (i) data about PSH presence recorded in hospital notes, (ii) independent expert review of the computed tomography scan and (iii) patient report of being informed of a PSH by a health professional.ResultsFor phase 1, 169 and 127 domains were identified from 70 PROMs and 29 interviews respectively. In phase 2, 14 domains specific to PSH were identified and operationalized into questionnaire items. Think‐aloud interviews led to three minor modifications. In phase 3, 44 completed questionnaires were obtained. Missing data were few: 5/660 items. PSH symptom scores associated with PSH presence varied between different data sources. The scale with the most consistent differences between PSH presence and absence and all data sources was the stoma appearance scale.ConclusionA PROM to examine the symptoms of PSH has been developed from the literature and views of key informants. Although preliminary testing shows it to be understandable and acceptable it is uncertain if it is sensitive to PSH‐specific symptoms and further psychometric testing is needed.
Geographies of storage
Authors: Randle Sayd 
Published: January 2024

AbstractResource storage has long played a key role in the production of socio‐ecological arrangements and economic relations. Even so, storage as a concept has remained somewhat marginal within geographical scholarship, often obscured by an analytical focus on the dynamics of movement. Reviewing recent works from geography, science and technology studies, and anthropology that center sites and practices of storage, this essay elaborates the diverse ways in which storage arrangements mediate resource circulation and the production of space. This literature demonstrates that thinking systematically with storage can illuminate a range of novel temporal, material, and value entanglements in‐the‐making, pointing to potentially fruitful avenues for future research.
How to mobilise users' experiential knowledge in the evaluation of advanced technologies and practices in Quebec? The example of the permanent users' and relatives' panel
Authors: Pomey Marie‐Pascale , Pelaez Sandra , Le Roux Enora , Demers‐Payette Oliver , Sirois Marie‐Claude , Lochhead Louis , Ganache Isabelle , Normandin Louise , L'Espérance Audrey , de Guise Michèle 
Published: January 2024

AbstractIntroductionWith the purpose of supporting scientific professionals and helping them to better integrate the expertise of users in their work, a users' and relatives' panel (URP) was set up at the National Institute for Excellence in Health and Social Services in Quebec (INESSS), Canada for the social services and mental health directorate. URPs are advisory structures that mobilise the experiential knowledge of people affected by various issues.ObjectivesThe objective of this study is to assess from a diverse stakeholders' perceptions: (1) the experience of developing and implementing the URP within the context of an Agencies for Health Technology Assessment and Assessment of Social Services (AHTAASS), (2) the contribution of such a URP, (3) the challenges encountered and (4) the perspectives of improvement for the following years.MethodologyWe conducted a qualitative descriptive evaluation study. Nineteen interviews were conducted: six with URP members and 13 with staff representatives. The documents related to the creation of the panel, the URP minutes summarising the discussions and the reports published during that period were collected and analysed. Following a preliminary round of data analysis, a debriefing meeting was conducted with a few participants to validate the results.ResultsThe panel was set up as part of the INESSS' desire to better integrate experiential knowledge into its recommendations. Twelve projects were presented to the panel on various themes. The URP enabled health professionals to consider dimensions they had not identified, to better integrate the experiential data collected from users into their work and to develop recommendations that made more sense to users. Panel members and INESSS professionals learned to work together, moving the working methods from consultation to collaboration and even coconstruction. Based on the panel's significant contribution, the INESSS decided to maintain it and to strengthen its place in its system to better integrate the experiential knowledge of users into its work.ConclusionThis research illustrates how AHTAASS can set up a URP composed exclusively of users, and how it can contribute and be evaluated. It shows that URPs are structures that value the sharing of experiential knowledge of its members, humanise decision‐making and give meaning to the work done by scientific professionals.Patient or Public ContributionOne patient–researcher has contributed to the preparation and writing of this manuscript.
Responses of the hyper‐diverse community of canopy‐dwelling Hymenoptera to oak decline
Authors: Le Souchu E. , Cours J. , Cochenille T. , Bouget C. , Bankhead‐Dronnet S. , Braet Y. , Burguet P. , Gabard C. , Galkowski C. , Gereys B. , Herbrecht F. , Joncour B. , Marhic E. , Michez D. , Buhl P. Neerup , Noblecourt T. , Notton D. G. , Penigot W. , Rasplus J.‐Y. , Robert T. , Staverlokk A. , Vincent‐Barbaroux C. , Sallé A. 
Published: January 2024

Abstract
Forest decline and dieback are growing phenomena worldwide, resulting in severe, large‐scale degradation of the canopy. This can profoundly alter the provision of trophic resources and microhabitats for canopy‐dwelling arthropods.
In 2019, we assessed the effect of oak decline on the community of canopy‐dwelling Hymenoptera. We selected 21 oak stands and 42 plots, located in three forests in France, presenting contrasting levels of decline. Insects were sampled at the canopy level with green multi‐funnel and flight‐interception traps.
We collected a particularly diverse community of 19,289 insect individuals belonging to 918 taxa, 10 larval trophic guilds and 7 nesting guilds.
Oak decline had no effect on the abundance or richness of the overall community but significantly reshaped the community assemblages. Decline had contrasting effects depending on the taxa and guilds considered. Specialist parasitoids were more abundant at intermediate levels of decline severity while generalists were negatively affected. Taxa depending on ground‐related resources and microhabitats were promoted. Saproxylic taxa were more abundant while xylophagous insects were negatively impacted.
Reduced leaf area index promoted several guilds and the diversity of the overall community. While an increasing tree mortality rate enhanced the abundance and diversity of deadwood resources, it had negative impacts on several Hymenoptera guilds. Our results suggest that micro‐environmental changes at the ground level due to canopy decline have major cascading effects on the communities of canopy‐dwelling Hymenoptera.
Our study highlights the relevance of studying Hymenoptera communities to investigate the outcomes of disturbances on forest biodiversity.
Self‐templated magnesiothermic reduction of ORMOSIL particles to monodisperse hollow spherical SiC composite particles
Authors: Jung Gyu Il , Lim Hyung Jun , Lee Sang Min , Koo Sang Man 
Published: January 2024

AbstractHollow silicon carbide (SiC) particles have attracted attention due to their well‐defined morphology, low density, and large surface area that can be leveraged for a wide variety of applications. Here, we report the self‐templated synthesis of monodisperse hollow spherical SiC composite particles with controllable shell thicknesses using magnesiothermic reduction of organically modified silica (ORMOSIL) particles. Monodisperse ORMOSIL particles containing three organic groups of methyl, vinyl, and mercaptopropyl were produced by a simple one‐pot sol–gel process and then converted to hollow spherical SiC composite particles via a magnesiothermic reduction at 700°C under an inert atmosphere. The spherical morphologies of the original ORMOSIL particles were well maintained through this self‐templated conversion process, but the sizes of the hollow SiC particles were slightly reduced by the thermal treatment. Field emission transmission electron microscopy studies revealed that the shell of hollow particles mainly consists of primary β‐SiC particles with nanometer‐scale sizes. The physical and chemical properties of the hollow SiC composite particles were investigated by scanning electron microscopy, transmission electron microscopy, X‐ray photoelectron spectroscopy, Brunauer–Emmett–Teller, X‐ray diffraction, Fourier transform infrared spectroscopy, Raman, and solid‐state nuclear magnetic resonance analyses. The shell thickness of hollow spherical SiC composite particles can be controlled by simply changing the duration of the thermal conversion process. This study not only provides a simple and easy approach for the preparation of hollow spherical SiC particles but also opens the possibility of large‐scale manufacturing of such particles for commercial applications.
Conduction time around the mitral valve annulus has the potential to rule out postablation perimitral atrial tachycardia
Authors: Hara Satoshi , Miwa Naoyuki , Kusa Shigeki , Sato Yoshikazu , Doi Junichi , Nakata Tadanori , Hirano Hidenori , Ishizawa Taiki , Hachiya Hitoshi 
Published: January 2024

AbstractIntroductionIt would be helpful in determining ablation strategy if the occurrence of perimitral atrial tachycardia (PMAT) could be predicted in advance. We investigated whether estimated perimitral conduction time (E‐PMCT), namely, twice the time between coronary sinus (CS) pacing and the ensuing wave‐front collision at the opposite side of the mitral annulus, correlated with the cycle length of PMAT and could predict future PMAT.Methods and ResultsWe retrospectively (retrospective cohort) and prospectively (validation cohort) investigated atrial fibrillation patients who had received pulmonary vein isolation (PVI) and in whom left atrial maps had been created during CS pacing. We calculated their E‐PMCT. PMAT was observed either by provocation or during follow‐up in 25, AT other than PMAT was observed in 24 (non‐PMAT AT group), and 53 patients never displayed any AT (no‐AT group) in the retrospective cohort. In the PMAT group of the retrospective cohort, a strong positive correlation was observed between the PMAT CL and E‐PMCT (r = .85, p < 0.001). PMAT was never induced nor observed in patients with E‐PMCT less than 176 ms, and the best cut‐off value for PMAT was 180 ms by receiver‐operating characteristic curve analysis. In the validation cohort of 76 patients, the cut‐off value of the E‐PMAT less than 180 ms predicted noninducibility of PMAT, with a sensitivity of 78.6%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 25.0%.ConclusionShort E‐PMCT may predict noninducibility of PMAT and guide a less invasive ablation strategy.
Care models for patients with heart failure at home: A systematic review
Authors: Zhao Xuetong , Wu Shuang , Luo Nan , Lin Qiuxia , Zhao Xinyi , Li Kun 
Published: January 2024

AbstractAimsThe aim of this study is to evaluate the relative merits of various heart failure models of care with regard to a variety of outcomes.DesignSystematic review.Data SourcesFive databases including PubMed, Web of Science, Medline, Embase and Science Direct were searched from the inception date of databases to August 20, 2022.Review MethodsThis review used the Cochrane Collaboration's ‘Risk of Bias’ tool to assess quality. Only randomised controlled trails were included in this review that assessed all care models in the management of adults with heart failure. A categorical summary of the pattern of the papers was found, followed by extraction of outcome indicators.ResultsTwenty articles (19 studies) were included. Seven examined nurse‐led care, two examined multidisciplinary specialist care, nine (10 articles) examined patient self‐management, and one examined nurse and physiotherapist co‐led care. Regarding outcomes, this review examined how well the four models performed with regard to quality of life, health services use, HF self‐care, and anxiety and depression for heart failure patients. The model of patient self‐management showed more beneficial results than nurse‐led care, multidisciplinary specialist care, and nurse and physiotherapist co‐led care in reducing hospital days, improving symptoms, promoting self‐care behaviours of HF patients, enhancing the quality of life, and strengthening self‐care ability.ConclusionsThis systematic review synthesises the different care models and their relative effectiveness. Four different models of care were summarised. Of these models, the self‐management model demonstrated better outcomes.ImpactThe self‐management model is more effective in increasing self‐management behaviours and self‐management abilities, lowering the risk of hospitalisation and death, improving quality of life, and relieving anxiety and depression than other models.No Patient or Public ContributionThere was no funding to remunerate a patient/member of the public for this review.
Pilotins are mobile T3SS components involved in assembly and substrate specificity of the bacterial type III secretion system
Authors: Wimmi Stephan , Fleck Moritz , Helbig Carlos , Brianceau Corentin , Langenfeld Katja , Szymanski Witold G. , Angelidou Georgia , Glatter Timo , Diepold Andreas 
Published: January 2024

AbstractIn animal pathogens, assembly of the type III secretion system injectisome requires the presence of so‐called pilotins, small lipoproteins that assist the formation of the secretin ring in the outer membrane. Using a combination of functional assays, interaction studies, proteomics, and live‐cell microscopy, we determined the contribution of the pilotin to the assembly, function, and substrate selectivity of the T3SS and identified potential new downstream roles of pilotin proteins. In absence of its pilotin SctG, Yersinia enterocolitica forms few, largely polar injectisome sorting platforms and needles. Accordingly, most export apparatus subcomplexes are mobile in these strains, suggesting the absence of fully assembled injectisomes. Remarkably, while absence of the pilotin all but prevents export of early T3SS substrates, such as the needle subunits, it has little effect on secretion of late T3SS substrates, including the virulence effectors. We found that although pilotins interact with other injectisome components such as the secretin in the outer membrane, they mostly localize in transient mobile clusters in the bacterial membrane. Together, these findings provide a new view on the role of pilotins in the assembly and function of type III secretion injectisomes.