bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional electrospun nanofibrous scaffold enriched with alendronate and hydroxyapatite for balancing osteogenic and osteoclast activity to promote bone regeneration
Authors: Anjum Shabnam , Arya Dilip Kumar , Saeed Mohammad , Ali Daoud , Athar Mohammad Saud , Yulin Wang , Alarifi Saud , Wu Xixi , Rajinikanth P.S. , Ao Qiang 
Published: November 2023

Electrospun composite nanofiber scaffolds are well known for their bone and tissue regeneration applications. This research is focused on the development of PVP and PVA nanofiber composite scaffolds enriched with hydroxyapatite (HA) nanoparticles and alendronate (ALN) using the electrospinning technique. The developed nanofiber scaffolds were investigated for their physicochemical as well as bone regeneration potential. The results obtained from particle size, zeta potential, SEM and EDX analysis of HA nanoparticles confirmed their successful fabrication. Further, SEM analysis verified nanofiber’s diameters within 200–250 nm, while EDX analysis confirmed the successful incorporation of HA and ALN into the scaffolds. XRD and TGA analysis revealed the amorphous and thermally stable nature of the nanofiber composite scaffolds. Contact angle, FTIR analysis, Swelling and biodegradability studies revealed the hydrophilicity, chemical compatibility, suitable water uptake capacity and increased in-vitro degradation making it appropriate for tissue regeneration. The addition of HA into nanofiber scaffolds enhanced the physiochemical properties. Additionally, hemolysis cell viability, cell adhesion and proliferation by SEM as well as confocal microscopy and live/dead assay results demonstrated the non-toxic and biocompatibility behavior of nanofiber scaffolds. Alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) assays demonstrated osteoblast promotion and osteoclast inhibition, respectively. These findings suggest that developed HA and ALN-loaded PVP/PVA-ALN-HA nanofiber composite scaffolds hold significant promise for bone regeneration applications.
A GIS-based study on the spatial distribution and influencing factors of monastic gardens in Jiangxi Province, China
Authors: Zhang Ting , Hu Yuzhu , Lei Tingting , Hu Haihui 
Published: November 2023

The temple gardens are an important human landscape and have an important position in the Chinese garden system. Using GIS analysis tools, primarily the Nearest Neighbor Index, Kernel Density Estimation, and Spatial Autocorrelation, and employing a Geographic Detector model, we analyzed the spatial distribution characteristics and influencing factors of 4,317 temples and gardens in Jiangxi Province. Research shows that: 1) The spatial distribution type of temple gardens in Jiangxi Province is agglomeration type, with large spatial differences in distribution, forming a spatial distribution pattern of “generally dispersed and concentrated in some areas”; 2) the distribution of temple gardens in Jiangxi Province is uneven. They are mostly distributed in five prefecture-level cities: Ganzhou, Jiujiang, Shangrao, Fuzhou, and Nanchang; 3) The overall spatial distribution of temple gardens in Jiangxi Province has positive autocorrelation characteristics, and prefecture-level cities have significant proximity characteristics, forming a “high-high” “agglomeration” and “low-low agglomeration” distribution patterns; 4) Temple gardens in various regions are affected by geomorphological factors, and are mostly concentrated in the lower altitude range of 0–500 m and the gentle slope of 0°–30°. Most of the distribution density of temple gardens in various prefecture-level cities is within the buffer zone distance of the road network within the range of 0–1.5 km. 5) Economic, cultural, demographic, and historical factors have affected the development of temple gardens. Areas with more active economies have a denser number of temple gardens. The unique regional culture affects the distribution of temples and gardens in different regions. In places where the modern population is densely distributed, there are fewer temples and gardens, while in places where the population is less densely distributed, there are more temples and gardens. 6) The use of geographical detectors to detect influencing factors shows that the greatest impact on the spatial distribution of temple gardens in Jiangxi Province is the road network, followed by elevation, slope, GDP, and water systems. The research is conducive to scientific understanding of the distribution of temple gardens among prefecture-level cities in Jiangxi Province, and provides reference for strengthening the protection of temple gardens and exploring the tourism characteristics of temple gardens.
CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior
Authors: Fernandes Luciana , Kleene Ralf , Congiu Ludovica , Freitag Sandra , Kneussel Matthias , Loers Gabriele , Schachner Melitta 
Published: November 2023

IntroductionThe dopaminergic system plays a key role in the appropriate functioning of the central nervous system, where it is essential for emotional balance, arousal, reward, and motor control. The cell adhesion molecule close homolog of L1 (CHL1) contributes to dopaminergic system development, and CHL1 and the dopamine receptor D2 (D2R) are associated with mental disorders like schizophrenia, addiction, autism spectrum disorder and depression.MethodsHere, we investigated how the interplay between CHL1 and D2R affects the behavior of young adult male and female wild-type (CHL+/+) and CHL1-deficient (CHL1−/−) mice, when D2R agonist quinpirole and antagonist sulpiride are applied.ResultsLow doses of quinpirole (0.02 mg/kg body weight) induced hypolocomotion of CHL1+/+ and CHL1−/− males and females, but led to a delayed response in CHL1−/− mice. Sulpiride (1 mg/kg body weight) affected locomotion of CHL1−/− females and social interaction of CHL1+/+ females as well as social interactions of CHL1−/− and CHL1+/+ males. Quinpirole increased novelty-seeking behavior of CHL1−/− males compared to CHL1+/+ males. Vehicle-treated CHL1−/− males and females showed enhanced working memory and reduced stress-related behavior.DiscussionWe propose that CHL1 regulates D2R-dependent functionsin vivo. Deficiency of CHL1 leads to abnormal locomotor activity and emotionality, and to sex-dependent behavioral differences.
Activity-dependent ectopic action potentials in regular-spiking neurons of the neocortex
Authors: Zhang Yizhen Z. , Sapantzi Stella , Lin Alice , Doelfel Savannah R. , Connors Barry W. , Theyel Brian B. 
Published: November 2023

IntroductionAction potentials usually travel orthodromically along a neuron’s axon, from the axon initial segment (AIS) toward the presynaptic terminals. Under some circumstances action potentials also travel in the opposite direction, antidromically, after being initiated at a distal location. Given their initiation at an atypical site, we refer to these events as “ectopic action potentials.” Ectopic action potentials (EAPs) were initially observed in pathological conditions including seizures and nerve injury. Several studies have described regular-spiking (RS) pyramidal neurons firing EAPs in seizure models. Under nonpathological conditions, EAPs were reported in a few populations of neurons, and our group has found that EAPs can be induced in a large proportion of parvalbumin-expressing interneurons in the neocortex. Nevertheless, to our knowledge there have been no prior reports of ectopic firing in the largest population of neurons in the neocortex, pyramidal neurons, under nonpathological conditions.MethodsWe performed in vitro recordings utilizing the whole-cell patch clamp technique. To elicit EAPs, we triggered orthodromic action potentialswith either long, progressively increasing current steps, or with trains of brief pulses at 30, 60, or 100 Hz delivered in 3 different ways, varying in stimulus and resting period duration.ResultsWe found that a large proportion (72.7%) of neocortical RS cells from mice can fire EAPs after a specific stimulus in vitro, and that most RS cells (56.1%) are capable of firing EAPs across a broad range of stimulus conditions. Of the 37 RS neurons in which we were able to elicit EAPs, it took an average of 863.8 orthodromic action potentials delivered over the course of an average of ~81.4 s before the first EAP was seen. We observed that some cells responded to specific stimulus frequencies while less selective, suggesting frequency tuning in a subset of the cells.DiscussionOur findings suggest that pyramidal cells can integrate information over long time-scales before briefly entering a mode of self-generated firing that originates in distal axons. The surprising ubiquity of EAP generation in RS cells raises interesting questions about the potential roles of ectopic spiking in information processing, cortical oscillations, and seizure susceptibility.
Visual motion detection thresholds can be reliably measured during walking and standing
Authors: DiBianca Stephen , Jeka John , Reimann Hendrik 
Published: November 2023

IntroductionIn upright standing and walking, the motion of the body relative to the environment is estimated from a combination of visual, vestibular, and somatosensory cues. Associations between vestibular or somatosensory impairments and balance problems are well established, but less is known whether visual motion detection thresholds affect upright balance control. Typically, visual motion threshold values are measured while sitting, with the head fixated to eliminate self-motion. In this study we investigated whether visual motion detection thresholds: (1) can be reliably measured during standing and walking in the presence of natural self-motion; and (2) differ during standing and walking.MethodsTwenty-nine subjects stood on and walked on a self-paced, instrumented treadmill inside a virtual visual environment projected on a large dome. Participants performed a two-alternative forced choice experiment in which they discriminated between a counterclockwise (“left”) and clockwise (“right”) rotation of a visual scene. A 6-down 1-up adaptive staircase algorithm was implemented to change the amplitude of the rotation. A psychometric fit to the participants’ binary responses provided an estimate for the detection threshold.ResultsWe found strong correlations between the repeated measurements in both the walking (R = 0.84, p &lt; 0.001) and the standing condition (R = 0.73, p &lt; 0.001) as well as good agreement between the repeated measures with Bland–Altman plots. Average thresholds during walking (mean = 1.04°, SD = 0.43°) were significantly higher than during standing (mean = 0.73°, SD = 0.47°).ConclusionVisual motion detection thresholds can be reliably measured during both walking and standing, and thresholds are higher during walking.
Economic effects of dietary salt reduction policies for cardiovascular disease prevention in Japan: a simulation study of hypothetical scenarios
Authors: Ikeda Nayu , Yamashita Hitomi , Hattori Jun , Kato Hiroki , Nishi Nobuo 
Published: November 2023

ObjectiveReducing dietary salt intake is an essential population strategy for cardiovascular disease (CVD) prevention, but evidence on healthcare costs and outcomes is limited in Japan. We aimed to conduct a pilot economic evaluation under hypothetical scenarios of applying the salt reduction policies of England to Japan.MethodsWe examined salt reduction policies in England: media health promotion campaigns, front-of-pack labeling, and voluntary and mandatory reformulation with best-case and worst-case policy cost scenarios. We assumed that these policies were conducted in Japan for 10 years from 2019. We used published data on epidemiology and healthcare expenditures in Japan and the costs and effects of salt reduction policies in England, and defined the benefits as a decrease in national medical expenditures on CVD. We developed a Markov cohort simulation model of the Japanese population. To estimate the annual net benefits of each policy over 10 years, we subtracted monitoring and policy costs from the benefits. We adopted a health sector perspective and a 2% discount rate.ResultsThe cumulative net benefit over 10 years was largest for mandatory reformulation (best case) at 2,015.1 million USD (with costs of USD 48.3 million and benefits of USD 2063.5 million), followed by voluntary reformulation (net benefit: USD 1,895.1 million, cost: USD 48.1 million, benefit: USD 1,943.2 million), mandatory reformulation (worst case, net benefit: USD 1,447.9 million, cost: USD 1,174.5 million, benefit: USD 2,622.3 million), labeling (net benefit: USD 159.5 million, cost: USD 91.6 million, benefit: USD 251.0 million), and a media campaign (net benefit: USD 140.5 million, cost: USD 110.5 million, benefit: USD 251.0 million). There was no change in the superiority or inferiority of policies when the uncertainty of model parameters was considered.ConclusionMandatory reformulation with the best-case cost scenario might be economically preferable to the other alternatives in Japan. In future research, domestic data on costs and effects of salt reduction policies should be incorporated for model refinement.
Bibliometric and visual analysis of doxorubicin-induced cardiotoxicity
Authors: Lin Xiaoxiao , Wu Guomin , Wang Shuai , Huang Jinyu 
Published: November 2023

Background: Doxorubicin-induced cardiotoxicity represents a prevalent adverse effect encountered in patients undergoing treatment with doxorubicin. To date, there has been no bibliometric study to summarize the field of doxorubicin-induced cardiotoxicity. In our study, we aim to determine the current status and frontiers of doxorubicin-induced cardiotoxicity by bibliometric analysis.Methods: The documents concerning doxorubicin-induced cardiotoxicity are obtained from the Web of Science Core Collection database (WOSCC), and VOSviewer 1.6.16, CiteSpace 5.1.3 and the WOSCC’s literature analysis wire were used to conduct the bibliometric analysis.Results: In total, 7,021 publications were encompassed, which are produced by 37,152 authors and 6,659 organizations, 1,323 journals, and 101 countries/regions. The most productive author, institution, country and journal were Bonnie Ky with 35 publications, University of Texas with 190 documents, the United States with 1,912 publications, and PLOS ONE with 120 documents. The first high-cited article was published in the NEJM with 8,134 citations authored by DJ Slamon et al., in 2001. For keyword analysis, there are four clusters depicted in distinct directions. The keywords in the red cluster are oxidative stress, apoptosis, and cardiomyopathy. The keywords in the green cluster are cardiotoxicity, heart failure, and anthracycline. The keywords in the blue cluster are chemotherapy, trastuzumab, and paclitaxel. The keywords in the purple cluster are doxorubicin, adriamycin, and cancer. Most of the documents were derived from the United States, China and Italy (4,080/7,021, 58.1%). The number of studies from other countries should be increased.Conclusion: In conclusion, the main research hotspots and frontiers in the field of doxorubicin-induced cardiotoxicity include the role of doxorubicin in cardiotoxicity, the mechanisms underlying doxorubicin-induced cardiotoxicity, and the development of treatment strategies for doxorubicin-induced cardiotoxicity. More studies are needed to explore the mechanisms and treatment of doxorubicin-induced cardiotoxicity.
Gender differences in spontaneous adverse event reports associated with zolpidem in South Korea, 2015–2019
Authors: Joung Kyung-In 
Published: November 2023

Study objectives: While zolpidem is considered as an example of a gender effect on drug response, there is insufficient evidence to reach a consensus. This study aimed to investigate gender differences in adverse events (AEs) of zolpidem.Methods: We estimated the difference between the reporting odds ratios (RORs) calculated in gender subgroups for the AEs signals detected in data mining using 2015–2019 Korea voluntary adverse drug events reporting system (KAERS) data. Different reporting risk by gender was evaluated by using the log RORs being significantly different by gender at the 5% significance level and the 95% confidence intervals of the gender ROR.Results: A total of 94 AE signals were detected. Among these, 35 signals showed significant disparities by gender at the 5% level or were detected only in one gender. When categorized by similarity of AEs, parasomnia including somnambulism and paroniria, and cardiovascular disorders including coronary thrombosis had higher reporting risks in women. Men were more likely to report cognitive disorders such as delirium, insomnia related disorders, and movement disorders. Among all AEs with gender differences in reporting risk, the difference in somnambulism was the most consistent and substantial.Conclusion: For several AEs associated with zolpidem, gender-based reporting disparities were evident. Notably, women exhibited a higher susbeptibility to somnambulism, potentially serious adverse effects of zolpidem. This underscores the need for further investigation into the underlying factors influencing these gender-specific reporting patterns.
Jurisprudencialismo de Castanheira Neves: um diálogo com as decisões de dano extrapatrimonial na esfera trabalhista
Authors: Bandeira Dennys Alberto Gonzalez , De Oliveira Paulo Eduardo Vieira 
Published: November 2023

Neste estudo, pretende-se analisar, por meio do método dialético, a inovação da reforma trabalhista na tarifação do dano moral, abordando a discricionariedade do juiz diante desse novo cenário e levando em conta a peculiar característica do Jurisprudencialismo de Castanheira Neves, a importância dessa teoria está na possibilidade de imprimir uma maior racionalidade prática ao ato decisório. Deste modo, sendo um tribunal capaz de atingir certo nível de padronização, o não tabelamento tem a vantagem de conciliar segurança jurídica com manutenção da possibilidade de levar em conta circunstâncias novas, não previsíveis. Ademais, a possibilidade de revisão decorrente do duplo grau de jurisdição e diante do vasto acervo jurisprudencial em relação a fixação de indenizações por danos à direitos da personalidade, atribui maior segurança na fixação dos valores indenizatórios.
THE EFFECT OF PEOPLE, PHYSICAL EVIDENCE, PROCESS AND PRICE FAIRNESS ON PATIENT SATISFACTION AND REVISIT INTENTION AT THE XYZ HOSPITAL POLYCLINIC, MAKASSAR CITY
Authors: Angelica Vena , Bernarto Innocentius 
Published: November 2023

Abstract This study aims to determine the factors of patient satisfaction and the effect on revisit intention. The factors are people, physical evidence, process and price fairness. A written questionnaire is used in collecting respondent data. Total respondents obtained were 277 people. Convenience sampling method is used as a sampling method. The collected data were analyzed using PLS-SEM with SmartPLS software. The research results obtained are people, physical evidence and price fairness that have a positive effect on patient satisfaction. However, for the process variable it was found to have no positive effect on patient satisfaction. Patient satisfaction has a positive effect on revisit intention. The people factor is the most influential factor on patient satisfaction.

Abstrak Penelitian ini bertujuan untuk mengetahui faktor kepuasan pasien dan pengaruhnya terhadap niat berkunjung kembali. Faktor tersebut adalah manusia, bukti fisik, proses dan keadilan harga. Kuesioner tertulis digunakan dalam mengumpulkan data responden. Total responden yang diperoleh adalah 277 orang. Metode convenience sampling digunakan sebagai metode pengambilan sampel. Data yang terkumpul dianalisis menggunakan PLS-SEM dengan perangkat lunak SmartPLS. Hasil penelitian yang diperoleh adalah people, physical evidence dan price fairness yang berpengaruh positif terhadap kepuasan pasien. Namun untuk variabel proses ditemukan tidak berpengaruh positif terhadap kepuasan pasien. Kepuasan pasien berpengaruh positif terhadap niat berkunjung kembali. Faktor people merupakan faktor yang paling berpengaruh terhadap kepuasan pasien
Condition-based Maintenance of Brake Pads and Tires in Shared Vehicles using Cloud-based Health monitoring and prognostics.
Authors: Lee Jeong Hae , Oh Jaewook , Lee Jeongwoo , Park Seungyoung , Lee Jihyeon , Kim Namsu 
Published: November 2023

Cloud-based prognostics and health management is a centralized method for monitoring the condition of individual shared vehicles and determining their maintenance schedules.In this study, we focused on monitoring the condition of brake pads and tires, as these crucial components require frequent and regular maintenance for safety. We developed a data acquisition system to transmit data from acoustic and vibration sensors to the cloud server. Useful and efficient features were extracted and selected from time and frequencydomains to assess the degradation of brake pads and tires. Moreover, based on feature extraction using the KruskalWallis method, we confirmed that diagnosing brake pad conditions with support vector machines (SVM) provides consistent result for classification of sevierities.. Our preliminary results suggest that cloud-based conditionmonitoring can be an effective approach to managing shared vehicles.
Ensemble Neural Networks for Remaining Useful Life (RUL) Prediction
Authors: Srinivasan Abhishek , Andresen Juan Carlos , Holst Anders 
Published: November 2023

A core part of maintenance planning is a monitoring system that provides a good prognosis on health and degradation, often expressed as remaining useful life (RUL). Most of the current data-driven approaches for RUL prediction focus on single-point prediction. These point prediction approaches do not include the probabilistic nature of the failure. The fewprobabilistic approaches to date either include the aleatoric uncertainty (which originates from the system), or the epistemic uncertainty (which originates from the model param-eters), or both simultaneously as a total uncertainty. Here, we propose ensemble neural networks for probabilistic RUL predictions which considers both uncertainties and decouples these two uncertainties. These decoupled uncertainties are vital in knowing and interpreting the confidence of the predictions. This method is tested on NASA’s turbofan jet engine CMAPSS data-set. Our results show how these uncertainties can be modeled and how to disentangle the contribution of aleatoric and epistemic uncertainty. Additionally, our approach is evaluated on different metrics and compared against the current state-of-the-art methods.
Data-driven Pump Performance Analysis Using Online Monitoring Data Accumulated with Supervisory Control and Data Acquisition System
Authors: Namba Ryo , Hokari Hiroyuki , Komine Hideaki 
Published: November 2023

Pump degradation has significant impacts on the operation of water treatment plants since pumps are widely used as basic facilities to supply and distribute water. The authors develop a method for quantifying pump performance to monitor pump degradation by using online monitoring data accumulated with a supervisory control and data acquisition (SCADA) system. The developed method estimates the performance of each pump from the measured values at the confluence of pipes with the least-squares method and respective on-off signals. From the viewpoint of practicality, the usefulness of the developed method was evaluated.