bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Perspective on Mechanisms of Neurodegeneration in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: the Early and Critical Role of Platelets in Neuro/Axonal Loss
Authors: Orian Jacqueline Monique 
Published: February 2025

Abstract
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disorder, with limited treatment options. This disease is characterized by differential pathophysiology between grey matter (GM) and white matter (WM). The predominant WM hallmark is the perivascular plaque, associated with blood brain barrier (BBB) loss of function, lymphocytic infiltration, microglial reactivity, demyelination and axonal injury and is adequately addressed with immunomodulatory drugs. By contrast, mechanisms underlying GM damage remain obscure, with consequences for neuroprotective strategies. Cortical GM pathology is already significant in early MS and characterized by reduced BBB disruption and lymphocytic infiltration relative to WM, but a highly inflammatory environment, microglial reactivity, demyelination and neuro/axonal loss. There is no satisfactory explanation for the occurrence of neurodegeneration without large-scale inflammatory cell influx in cortical GM. A candidate mechanism suggests that it results from soluble factors originating from meningeal inflammatory cell aggregates, which diffuse into the underlying cortical tissue and trigger microglial activation. However, the recent literature highlights the central role of platelets in inflammation, together with the relationship between coagulation factors, particularly fibrinogen, and tissue damage in MS. Using the experimental autoimmune encephalomyelitis (EAE) model, we identified platelets as drivers of neuroinflammation and platelet-neuron associations from the pre-symptomatic stage. We propose that fibrinogen leakage across the BBB is a signal for platelet infiltration and that platelets represent a major and early participant in neurodegeneration. This concept is compatible with the new appreciation of platelets as immune cells and of neuronal damage driven by inflammatory cells sequestered in the meninges.

Graphical Abstract
Premature Mortality and Health Inequality among Adult New Yorkers with Serious Mental Illness
Authors: Magas Iva , Norman Christina , Vasan Ashwin 
Published: February 2025

Abstract
Although numerous studies have documented excess mortality and health inequality among individuals with serious mental illness (SMI), none has been done among individuals in a large, diverse urban setting, such as New York City (NYC). We used referral data for adults aged 18 and older referred to the NYC Department of Health and Mental Hygiene public mental health services between January 2004 and December 2018 and matched it to the NYC death registry. Age at death, leading causes of death, years of potential life lost (YPLL), and standardized mortality ratios (SMRs) were calculated for this population. We found individuals with SMI in NYC died at younger ages and had higher rates of YPLL compared to the total population (147.4 YPLL vs. 66.8 YPLL per 1000 population). Age and gender-adjusted SMRs show these individuals have more than twice the mortality rate of the total NYC adult population (overall SMR 2.2 [95% CI 2.1–2.2]). Cause-specific SMRs show an increased risk of death among SMI from diabetes (SMR 2.8 [95% CI 2.4–3.10]), heart disease (SMR 2.7 [95% CI 2.6–2.9]), psychoactive substance use and accidental overdose (SMR 4.5 [95% CI 4.1–4.9]), and suicide (SMR 6.7 [95% CI 6.0–7.4]). Our results highlight the need to implement effective, preventive, and rehabilitative measures that integrate physical and behavioral healthcare services and address upstream drivers of health to achieve health equity and eliminate health disparities. In order to achieve gains in life expectancy, specific considerations for reducing excess mortality in the SMI population must be accounted for.
Variation in Defensive Strategies of Brown Frogs against Conspecific and Heterospecific Alarm Cues
Authors: Gazzola Andrea , Balestrieri Alessandro , Schulte Lisa M. , Lipkowski Konrad , Pellitteri-Rosa Daniele 
Published: February 2025

Abstract
Chemical cues released upon injury play a crucial role in mediating antipredator responses in many aquatic species. Prey populations capable of exploiting information from different sources may enhance their fitness, although the factors determining this ability are not always clear. In this study, we investigated the antipredator responses to both conspecific and heterospecific injury cues (i.e., alarm cues) in three brown frog species: Rana dalmatina, Rana latastei, and Rana temporaria. We recorded two tadpole defensive behaviours: the proportion of time spent inactive and the distance covered. Responses to a native odonate predator were used as a positive control. Tadpoles of R. dalmatina showed a clear decrease in activity in response to both con- and heterospecific cues, similar to their reaction to predator cues. Tadpoles of R. latastei slightly decreased activity in response to alarm cues from both agile frog species but did not react to common frog cues. Finally, R. temporaria exhibited high sensitivity to conspecific cues and a weak response to heterospecific cues. The phylogenetic-relatedness hypothesis seems to explain the observations for both R. latastei and R. temporaria, while for R. dalmatina, the ecological coexistence hypothesis, given its overlapping distribution with the other two species, seems to better explain the data. However, since the invoked hypotheses are not mutually exclusive, further analysis of other populations of these species is necessary to confirm the generality of these findings and to better understand the role of environmental factors in shaping these antipredator responses.
Boosting Drug Treatment Attendance Through Police-Sent Text Message Nudges: A Randomized Controlled Trial with Drug-Positive Arrestees
Authors: Dwyer Paul , Ariel Barak , Harinam Vincent 
Published: February 2025

Abstract
Attrition from drug treatment programs is a ubiquitous concern, but less is known about effective strategies to assist people with an addiction in arriving at the initial intake meeting. This study investigates whether text message reminders sent to drug-positive arrestees to participate in mandated drug treatment appointments increase attendance rates. We conducted a randomized controlled trial in London, and participants were randomly assigned to either a treatment group (n = 403) receiving a text message reminder or a control group (n = 410) receiving no text message. Participants were arrestees with a verified mobile phone number who tested positive for Class A drugs at intake across 25 custody suites and were scheduled for a drug treatment assessment at one of London’s 28 treatment facilities. The primary outcome was the attendance rate at drug treatment centers, which was analyzed using an ordinary least squares regression model. Results suggest that nudges have the potential to increase attendance at drug treatment centers among drug-positive arrestees. Although we have no additional outcome variables, the intervention shows promise as a cost-effective strategy for enhancing compliance with mandated rehabilitations. Future research should explore this intervention’s broader implications and effectiveness across diverse and more extensive samples.
Physical Activity Reduces the Incidence of Sarcopenia in Middle-Aged Adults
Authors: Luo Jin , Lee Raymond Y. W. 
Published: February 2025

Abstract

Purpose of the Research
The aim of this study was to investigate associations between physical activity and risk of sarcopenia in middle-aged adults.

Methods
This was a longitudinal study based on a subset of UK Biobank data consisting of 1,918 participants (902 men and 1,016 women, mean age 56 years) who had no sarcopenia at baseline based on the criteria of European Working Group on Sarcopenia in Older People (EWGSOP2). The participants were assessed again after 6 years at follow-up, and were categorized into no sarcopenia, probable sarcopenia, or sarcopenia using EWGSOP2. Physical activity was assessed at baseline using 7-day acceleration data that were analysed to obtain physical activity dose at different intensities. Multinominal logistic regression was employed to examine the association between the incidence of sarcopenia and physical activity dose, between baseline and follow up, controlled for other factors at baseline including age, sex, BMI, smoking status, intake of alcohol, vitamin D and calcium, history of rheumatoid arthritis, osteoarthritis, secondary osteoporosis, and type 2 diabetes.

Results
Among the 1918 participants with no sarcopenia at baseline, 230 (69 men and 161 women) developed probable sarcopenia and 37 (14 men and 23 women) developed sarcopenia at follow-up. Logistic regression models showed that increase in physical activity dose at moderate-to-vigorous intensity significantly reduced the risk of sarcopenia (odds ratio=0.368, p<0.05), but not probable sarcopenia (odds ratio=0.974, p>0.05), while physical activity dose at light or very light activity intensity were not associated with the risk of sarcopenia or probable sarcopenia (p>0.05).

Conclusions
Physical activity at moderate-to-vigorous intensity could reduce risk of sarcopenia in middle-aged adults.
Factorial structure and measurement invariance of the Italian version of the Cooper – Norcross Inventory of Preferences (C-NIP)
Authors: La Tona Antonino , Brugnera Agostino , Salerno Laura , Tasca Giorgio Angelo , Carrara Silvia , Lo Coco Gianluca , Greco Andrea , Cooper Mick , Norcross John C. , Compare Angelo 
Published: February 2025

Abstract
There is increasing evidence that psychotherapy efficacy can be enhanced by accommodating clients’ preferences regarding their role, the treatment, and the therapist. Several instruments are available to measure these concepts, although only the Cooper-Norcross Inventory of Preferences (C-NIP) appears particularly suitable for psychotherapy. This study aimed to validate the Italian version of the C-NIP and to provide norms for both clinical and research use for Italian-speaking individuals. We adopted a multi-step procedure to translate the C-NIP into Italian. Then, 1084 (70.3% females; Mage = 27.22 ± 11 years) Italian adults completed an online survey. Psychometric properties of both the original C-NIP and a revised, 15-item, five-scale version of this questionnaire were analysed through a Confirmatory Factor Analysis (CFA), McDonald’s omega coefficients, mean inter-item correlations, measurement invariance, and Pearson correlations. The Italian translation of the original version of the C-NIP scales did not show good psychometric properties. However, the CFA on a revised factorial structure of the C-NIP evidenced adequate fit to the data. We found good support for the unidimensionality of all scales, but only one of the scales demonstrated an acceptable internal consistency. Measurement invariance was confirmed across both patient sex and across individuals who were and were not in psychotherapy. Results showed that the revised version of the C-NIP has satisfactory factorial structure for use with Italian adults. More research is needed to investigate how preferences vary over time and in relation to psychopathologies and client characteristics.
Impact of Breast Cancer Systemic Therapies on Fertility
Authors: Hundal Jasmin , Moore Halle 
Published: February 2025

Abstract

Purpose of Review
This review examines the impact of breast cancer treatments on fertility in young women and explores strategies for fertility preservation. It highlights what is known about the effects of chemotherapy, hormonal therapies, and targeted treatments for breast cancer on ovarian function, emphasizing the importance of integrating fertility preservation into oncology care.

Recent Findings
Systemic treatments, including chemotherapy and targeted agents like PARP inhibitors and CDK4/6 inhibitors, have the potential to significantly affect ovarian reserve and fertility. As treatment protocols become more prolonged, patients may consider treatment interruption to attempt pregnancy, and studies such as the POSITIVE trial offer new insights into the safety of pregnancy after breast cancer.

Summary
Personalized fertility preservation strategies are essential for optimizing outcomes in young breast cancer patients. Ongoing research to better understand the effects of treatment on future fertility, as well as mitigation strategies, is necessary to support informed decision-making and improve quality of life.
Joint Guidance: A Capacity to Jointly Guide
Authors: Mattei Marco 
Published: February 2025

Abstract
Sometimes, we act in concert with others, as when we go for a walk together, or when two mathematicians try to prove a difficult theorem with each other. An interesting question is what distinguishes the actions of individuals that together constitute some joint activity from those that amount to a mere aggregation of individual behaviours. It is common for philosophers to appeal to collective intentionality to explain such instances of shared agency. This framework generalizes the approach traditionally used to explain individual action: a behaviour is an action just in case it causally follows from the relevant intention. Contemporary philosophers of action, as well as cognitive psychologists, however, have criticised this way of explaining individual actions, favouring instead an approach that puts “control” or “guidance” as the discerning factor: a behaviour is an action just in case the agent controls it, or just in case it is guided by the agent. In this paper, I argue that we should include talk of guidance even in cases of joint action. I first show that problems of deviant causation arise also in cases of joint action, and that therefore guidance is required to face this issue. Then, I show what a “capacity to jointly guide” amounts to for an individual in a group and how joint guidance relates to individual guidance. Joint guidance is actually constituted by task co-representation and the sense of being jointly committed. I argue that an approach that favours joint guidance over collective intentions eschews a lot of metaphysical problems about collective mentality and group subjects, and it is thus more explanatorily fruitful.
Digging deeper into the impacts of different soil water systems on the date palm root architecture and associated fungal communities
Authors: Robin-Soriano Alexandre , Vincent Bryan , Maurice Kenji , Battesti Vincent , Boukcim Hassan , Ducousso Marc , Gros-Balthazard Muriel 
Published: February 2025

Abstract
In arid regions, excessive water use threatens agricultural sustainability and overall livelihoods. It is essential to minimize water consumption to address these issues. Date palm (Phoenix dactylifera L.) is an emblematic crop of arid regions and a major water consumer. Adapting current irrigation systems to be more water-efficient systems could help cope with the water consumption of this crop. Microbial communities associated with plants are essential for agricultural sustainability and could improve the water use efficiency in regions threatened by water scarcity. These communities should thus be seriously taken into account when adapting agrosystems to the current global change setting. However, no information is presently available on the effects of the different soil water systems on date palm microbial communities. This study highlights the impact of different soil water systems (flooding and drip irrigation, natural conditions and abandoned farms) on date palm root fungal communities at different soil depths (40, 80 and 140 cm deep). The findings revealed that the soil water systems had a marked impact on fungal communities and that drip irrigation reduced the fungal diversity but increased the abundance of arbuscular mycorrhizal fungi. We showed that these effects were similar at all sampling depths. Finally, as the root architecture is a major determinant of water uptake, we reveal different behaviors of the root architecture under these different soil water systems to 160 cm depth. The findings of this study give new insights into the date palm root architecture and associated fungal communities, particularly in the context of the water availability crisis, which drives the adaptation of agricultural systems.
Generalized Riesz potential operators on Musielak–Orlicz–Morrey spaces over unbounded metric measure spaces
Authors: Ohno Takao , Shimomura Tetsu 
Published: February 2025

Abstract
In this paper we discuss the boundedness of the Hardy–Littlewood maximal operator

$$M_{\lambda }, \ \lambda \ge 1$$

M
λ

,

λ
≥
1

, and the variable Riesz potential operator

$$I_{\alpha (\cdot ),\tau }, \ \tau \ge 1$$

I

α
(
·
)
,
τ

,

τ
≥
1

, on Musielak–Orlicz–Morrey spaces

$$L^{\Phi ,\kappa ,\theta }(X)$$

L

Φ
,
κ
,
θ

(
X
)

over unbounded metric measure spaces X. As an important example, we obtain the boundedness of

$$M_{\lambda }$$

M
λ

and

$$I_{\alpha (\cdot ),\tau }$$

I

α
(
·
)
,
τ

in the framework of double phase functionals with variable exponents

$$\Phi (x,t) = t^{p(x)} + a(x) t^{q(x)}, \ x \in X, \ t \ge 0$$

Φ

(
x
,
t
)

=

t

p
(
x
)

+
a

(
x
)

t

q
(
x
)

,

x
∈
X
,

t
≥
0

, where

$$p(x)<q(x)$$

p
(
x
)
<
q
(
x
)

for

$$x\in X$$

x
∈
X

,

$$a(\cdot )$$

a
(
·
)

is a non-negative, bounded and Hölder continuous function of order

$$\theta \in (0,1]$$

θ
∈
(
0
,
1
]

. Our results are new even for the variable exponent Morrey spaces or for the doubling metric measure case in that the underlying spaces need not be bounded.
Multi-centre data harmonisation applied to heart-to-mediastinum quantification in parkinsonism (ITA-MIBG): a cross-calibration phantom study with tube and bottle
Authors: Filippi Luca , Bianconi Francesco , Minestrini Matteo , De Vincentis Giuseppe , Frantellizzi Viviana , Marongiu Andrea , Ferrari Cristina , Giordano Alessia , D’Ambrosio Daniela , Gazzilli Maria , Bertagna Francesco , Bagni Oreste , Panareo Stefano , Guglielmo Priscilla , Lazzarato Achille , Casali Massimiliano , Aghakhanyan Gayane , Spanu Angela , Evangelista Laura , Schillaci Orazio , Palumbo Barbara 
Published: February 2025

Abstract

Purpose
Planar cardiac scintigraphy with [123I]I-mIBG is widely used to image myocardial sympathetic activity. In multicentre studies, different γ-cameras can cause variability in quantitative parameters. This study aimed to harmonise multicentre [123I]I-mIBG data using a custom-designed phantom and to assess its feasibility and acceptability.

Methods
A ‘tube and bottle’ phantom was designed to standardise the heart-to-mediastinum (H/M) ratio across 15 centres. Each centre prepared three versions of the phantom (A, B, and C) with varying pertechnetate ([99mTc]Tc-O4-) activities, acquired static images using their own γ-camera, and uploaded DICOM data to a shared platform. In the phantom, the tube and bottle represent the heart and mediastinum, respectively, with the tube-to-bottle (T/B) ratio simulating the H/M ratio. The reference centre analysed the images and calculated the T/B ratios, applying linear regression for data harmonisation. A survey was conducted to assess the phantom’s usability.

Results
The harmonised T/B ratios for versions A and B were 20.46 ± 0.78 and 6.19 ± 0.39, respectively. The average slope and intercept of the regression line across the participating centres resulted in 1.07 ± 0.38 and − 0.82 ± 4.95. Survey feedback indicated high feasibility and acceptability, with all centres recommending the phantom for multicentre harmonisation.

Conclusions
The custom-made phantom effectively harmonised experimental data across different centres, supporting its use in multicentre studies to improve data consistency.
Mapping the Gap: A Review of Residential Energy and Transportation Deficit Metrics
Authors: Nock Destenie , Maillacheruvu Sara Usha , Harper Corey 
Published: February 2025

Abstract

Purpose of Review
Energy poverty can fall into two broad categories: residential energy poverty and transportation energy poverty. While metrics exist to assess equity for each type of deficit individually, they often fail to account for interactions between the two sectors. This review focuses on poverty analyses within and at the intersection of the energy and transportation sectors.

Recent Findings
In recent years, there has been movement toward crafting metrics that account for the multidimensional nature of poverty. While these metrics allow for nuance, they can present issues around quality data access, pose challenges for comparison across national or regional contexts, and introduce bias by weighting schemas. Despite the challenges associated with composite-factor metrics, we argue that future studies should focus on developing energy deficits metrics that operate at the nexus of transportation and residential-based energy deficits, to consider the complex ways in which households’ energy consumption patterns are linked across dimensions.

Summary
This paper provides a literature review of 39 papers focused primarily on developed countries (e.g., Europe and North America), we classify transportation and energy deficit metrics as having single-factor inputs (e.g., only income) or composite-factor inputs (e.g., income and housing cost). We also classify metrics based upon the type of factors included in the model: income-based factors versus energy usage-based factors.
Efficacy and safety of SGLT2 inhibitors in the treatment of maturity-onset diabetes of the young (MODY): a case report and literature review
Authors: Bombonato Michelle , Beccuti Guglielmo , Benso Andrea , Giannone Beatrice , Bertaina Silvana , Broglio Fabio , Bioletto Fabio 
Published: February 2025

Abstract

Background
Sulfonylureas constitute the standard therapy for patients with HNF1A-MODY (maturity-onset diabetes of the young) but are characterized by an increased risk of hypoglycemia. While SGLT2 inhibitors (SGLT2i) may potentially represent a useful therapeutic option, data from the literature are scant.

Case presentation
We report the case of a young woman affected by HNF1A-MODY who was successfully and safely treated with an SGLT2i in addition to sulfonylurea. After SGLT2i initiation, an improvement in the patient’s glycemic control was observed and was maintained over time. No adverse effects were noted and, in particular, no increase in ketonemia or ketonuria occurred.

Conclusions
The use of SGLT2i under controlled circumstances may represent a useful therapeutic option in patients with HNF1A-MODY.