bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia
Authors: van Deventer Hendrik W. , Hall Melissa D. , Orlowski Robert Z. , Mitchell Beverly S. , Berkowitz Lee R. , Hogan Cathe , Dunphy Cherie H. , Koehler Julie , Shea Thomas C. 
Published: October 2002

AbstractWe studied 28 patients with accelerated phase chronic myelogenous leukemia (CML) who were enrolled on the Novartis expanded access study 114. Diagnosis of accel‐ erated phase CML was based on karyotypic evolution (n = 9) and hematologic criteria (n = 18). All patients were begun on 600 mg/day of imatinib mesylate. Dose reductions to 400 mg/day and then 300 mg/day were prescribed for an absolute neutrophil count (ANC) of <0.5/μl or a platelet count of <20,000/μl. Twenty‐seven of the 28 patients continued treatment for a median of 34 weeks. Eleven patients developed thrombocytopenia following an average of 8.4 ± 1.4 weeks of therapy. The onset of thrombocytopenia was associated with disease progression in one patient and a decline in bone marrow megakaryocytes in the other 10. Nine patients recovered to a platelet count of >20,000/μl after an average of 19.7 ± 1.8 weeks. Patients who developed thrombocytopenia had a longer duration of disease (9.39 vs. 4.35 years; P < 0.01) and were more likely to be diagnosed with accelerated phase CML by hematologic criteria. Hematologic responses in patients with and without thrombocytopenia were comparable; however, 31.3% of patients without thrombocytopenia had a complete cytogenetic response compared to none of those with thrombocytopenia. Grade III–IV thrombocytopenia is common in accelerated phase CML and may be a marker for the inability to achieve cytogenetic response using single agent imatinib mesylate. Am. J. Hematol. 71:184–190, 2002. © 2002 Wiley‐Liss, Inc.
Unusually indolent T‐cell prolymphocytic leukemia associated with a complex karyotype: Is this T‐cell chronic lymphocytic leukemia?
Authors: Soma Lorinda , Cornfield Dennis B. , Prager David , Nowell Peter , Bagg Adam 
Published: October 2002

AbstractT‐cell prolymphocytic leukemia (T‐PLL) is typically associated with an aggressive clinical course, with a median survival of less than 1 year. We report a case of T‐PLL that displays multiple cytogenetic abnormalities, with the most complex subclone having the following karyotype: 47, Y, −X, +8, inv (10) (p12q26), del (11) (p13p15) +marker. However, despite this genetic complexity, the leukemia has behaved in a remarkably indolent manner, with the patient remaining asymptomatic, without therapeutic intervention, for more than 7 years. The unusually benign behavior of this disease calls into question the validity of grouping such cases under the umbrella of T‐PLL and warrants a reconsideration of T‐cell chronic lymphocytic leukemia (no longer recognized as a distinct disease) as a bona fide diagnostic entity. Am. J. Hematol. 71:224–226, 2002. © 2002 Wiley‐Liss, Inc.
Unfounded attribution of the “half‐life” index‐number of literature obsolescence to Burton and Kebler: A literature science study
Authors: Száva‐Kováts Endre 
Published: October 2002

AbstractThe term and notion of the “half‐life” index‐number of literature obsolescence, as well as their borrowing from nuclear physics and adaptation into the literature of literature obsolescence, have up to now been attributed to the librarian Burton and the physicist Kebler and to their famous 1960 journal article. In this article it is documented that (1) Burton and Kebler in their 1960 article were not the first to use the term literature “half‐life”; (2) it was not Burton and Kebler who borrowed the conception of “half‐life” from nuclear physics and not them who adapted it into the literature of literature obsolescence; (3) in their 1960 article Burton and Kebler first made critical and later ambiguous statements, and finally attributed only “some validity” to the idea of literature half‐life; (4) Burton and Kebler stated and produced an argument to show that there is an essential difference between the nature of radioactive “half‐life” and that of literature “half‐life”, and they therefore disapproved the use of the latter term; (5) in his next article published in 1961 and entirely left out of consideration, Burton proposed the term “median age” of statistical nature in place of the term literature “half‐life”. For all these reasons it is unfounded and erroneous to continue to attribute the term and conception of literature “half‐life” to Burton and Kebler.
Using graded relevance assessments in IR evaluation
Authors: Kekäläinen Jaana , Järvelin Kalervo 
Published: October 2002

AbstractThis article proposes evaluation methods based on the use of nondichotomous relevance judgements in IR experiments. It is argued that evaluation methods should credit IR methods for their ability to retrieve highly relevant documents. This is desirable from the user point of view in modern large IR environments. The proposed methods are (1) a novel application of P‐R curves and average precision computations based on separate recall bases for documents of different degrees of relevance, and (2) generalized recall and precision based directly on multiple grade relevance assessments (i.e., not dichotomizing the assessments). We demonstrate the use of the traditional and the novel evaluation measures in a case study on the effectiveness of query types, based on combinations of query structures and expansion, in retrieving documents of various degrees of relevance. The test was run with a best match retrieval system (InQuery1) in a text database consisting of newspaper articles. To gain insight into the retrieval process, one should use both graded relevance assessments and effectiveness measures that enable one to observe the differences, if any, between retrieval methods in retrieving documents of different levels of relevance. In modern times of information overload, one should pay attention, in particular, to the capability of retrieval methods retrieving highly relevant documents.
The influence of mental models and goals on search patterns during Web interaction
Authors: Slone Debra J. 
Published: October 2002

AbstractThis article reports on a study that uses a new analysis and display tool to examine the influences of understanding the system and goals on end‐user Internet searching. Thirty‐one public library users were observed searching the Web and/or a Web‐based on‐line catalog. The study identified four user categories, distinguished by the number of search approaches employed. These included linking, use of search engines, URL use, on‐line catalog searching, and searching within a specific Web‐site domain. Results conclude that experience and motivation, elements of situational goals and mental models, work in tandem to determine search approaches, Web sites visited, and sources used. People who sought information for job‐related or educational purposes were highly motivated. Thus, they were persistent. Those who had a great deal of Internet experience used an array of tools; while those with immature mental models of the Internet relied more heavily on the Web on‐line catalog or off‐line sources. People seeking information for recreational or personal use were not highly motivated. Whether experienced or not, they relied on serendipity, linking, and other tasks that were not cognitively overbearing. When searching became too difficult, they abandoned the Internet as an information source.
Children's use of the Yahooligans! Web search engine. III. Cognitive and physical behaviors on fully self‐generated search tasks
Authors: Bilal Dania 
Published: October 2002

AbstractThis article presents the third part of a research project that investigated the information‐seeking behavior and success of seventh‐grade science children in using the Yahooligans! Web search engine/directory. In parts 1 and 2, children performed fully assigned tasks to pursue in the engine. In the present study, children generated their tasks fully. Children's information seeking was captured from the cognitive, physical, and affective perspectives using both quantitative and qualitative inquiry methods. Their information‐seeking behavior and success on the fully self‐generated task was compared to the behavior and success they exhibited in the two fully assigned tasks. Children were more successful on the fully self‐generated task than the two fully assigned tasks. Children preferred the fully self‐generated task to the two fully assigned tasks due to their ability to find the information sought and satisfaction with search results rather than the nature of the task in itself (i.e., self‐generated aspect). Children were more successful when they browsed than when they searched by keyword on the three tasks. Yahooligans! design, especially its poor keyword searching, contributed to the breakdowns children experienced. Implications for system design improvement and Web training are discussed.
Automatic thesaurus generation for Chinese documents
Authors: Tseng Yuen‐Hsien 
Published: October 2002

AbstractThis article reports an approach to automatic thesaurus construction for Chinese documents. An effective Chinese keyword extraction algorithm is first presented. Experiments showed that for each document an average of 33% keywords unknown to a lexicon of 123,226 terms could be identified by this algorithm. Of these unregistered words, only 8.3% of them are illegal. Keywords extracted from each document are further filtered for term association analysis. Association weights larger than a threshold are then accumulated over all the documents to yield the final term pair similarities. Compared to previous studies, this method speeds up the thesaurus generation process drastically. It also achieves a similar percentage level of term relatedness.
Algorithmic procedure for finding semantically related journals
Authors: Pudovkin Alexander I. , Garfield Eugene 
Published: October 2002

AbstractUsing citations, papers and references as parameters a relatedness factor (RF) is computed for a series of journals. Sorting these journals by the RF produces a list of journals most closely related to a specified starting journal. The method appears to select a set of journals that are semantically most similar to the target journal. The algorithmic procedure is illustrated for the journal Genetics. Inter‐journal citation data needed to calculate the RF were obtained from the 1996 ISI Journal Citation Reports on CD‐ROM©. Out of the thousands of candidate journals in JCR©, thirty have been selected. Some of them are different from the journals in the JCR category for genetics and heredity. The new procedure is unique in that it takes varying journal sizes into account.
5‐Alpha‐ and 5‐beta‐2‐deoxyintegristerone A, a 5‐alpha and 5‐beta isomer pair of ecdysteroids isolated from the Silene genus
Authors: Báthori M. , Kalász H. , Pongrácz Z. , Máthé I. , Kálmán A. , Argay G. 
Published: October 2002

Abstract5‐Alpha‐2‐deoxyintegristerone A and 5‐beta‐2‐deoxyintegristerone A were isolated from the aerial parts of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman using a specific combination of absorption column chromatography, preparative thin‐layer chromatography and preparative HPLC. Both normal‐phase and reversed‐phase modes of HPLC were employed for isolation. Structural elucidation of 5‐alpha‐2‐deoxyintegristerone A was completed by X‐ray diffraction. Both 5‐alpha‐2‐deoxyintegristerone A and 5‐beta‐2‐deoxyintegristerone A were firstly isolated from this plant. We propose that 5‐alpha‐2‐deoxyintegristerone A is not an artifact but an integral part of the ecdysteroid spectrum of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. Copyright © 2002 John Wiley & Sons, Ltd.
Analysis of reaction products of cocaine and hydrogen peroxide by high‐performance liquid chromatography/mass spectrometry
Authors: Tanaka Seishi , Iio Reiko , Chinaka Satoshi , Takayama Nariaki , Hayakawa Kazuichi 
Published: October 2002

AbstractThe change of chemical structure of cocaine in the presence of hydrogen peroxide, a main component of hair dye and decolorant treatments, was studied. High‐performance liquid chromatography/mass spectrometry (LC/MS) was used for the separation and identification of cocaine derivatives. After a mixture of cocaine and hydrogen peroxide solutions was incubated at 39°C (this temperature is commonly used when the hair is treated with hair dye or decolorant) for 24 h, six reaction products were detected by LC/MS. Two of them were ecgonine methyl ester and benzoylecgonine, which are metabolites of cocaine. The other reaction products were assumed to be ortho‐, meta‐ and para‐hydroxycocaines and dihydroxycocaine, in each of which the benzene ring was hydroxylated by the reaction. These five reaction products (except for dihydroxycocaine) were found immediately after mixing cocaine and hydrogen peroxide. Therefore, the above reaction products might be present in the hair of cocaine users that had treated their hair with hair dye or decolorant. Copyright © 2002 John Wiley & Sons, Ltd.
Rapid determination of anastrozole in plasma by gas chromatography with electron capture detection and its application to an oral pharmacokinetic study in healthy volunteers
Authors: Duan Gengli , Liang Jianying , Zuo Ming 
Published: October 2002

AbstractA rapid, sensitive and accurate capillary gas chromatographic assay with 63Ni electron capture detection was developed for the determination of anastrozole in human plasma. It comprises a one‐step liquid–liquid extraction procedure and gas chromatography on a capillary column using constant oven temperature. This method has been applied to the oral pharmacokinetic study of anastrozole in healthy Chinese male volunteers. Pharmacokinetic parameters of two anastrozole preparations were evaluated after single, oral administrations to 18 subjects at a dose of 1 mg in a single‐blind cross‐over trial. Plasma anastrozole concentration–time profiles were best described by a two‐compartment model. After oral administrations of imported and domestic anastrozole tablets, the tmax and Cmax were 1.52 ± 1.04 h and 8.75 ± 3.03 ng/mL for the former, and 1.43 ± 1.12 h and 9.44 ± 3.59 ng/mL for the latter; the elimination half‐life was 46.0 ± 25.2 h vs 41.2 ± 8.8 h, and the area under the curve (AUC) was 423 ± 114 ng h/mL vs 444 ± 157 ng h/mL. The result indicates that the two products are bioequivalent. Copyright © 2002 John Wiley & Sons, Ltd.
In vitro metabolism of a novel phosphodiesterase‐5 inhibitor DA‐8159 in rat liver preparations using liquid chromatography/electrospray mass spectrometry
Authors: Choi Sung Jin , Ji Hye Young , Lee Hee‐Yong , Kim Dong Sung , Kim Won Bae , Lee Hye Suk 
Published: October 2002

AbstractThe in vitro metabolism of a new erectogenic, DA‐8159, has been studied by LC with UV detection and on‐line LC‐electrospray mass spectrometry using rat hepatic microsomal incubation and rat liver perfusion. Both rat liver microsomal incubation of DA‐8159 in the presence of NADPH and single‐pass liver perfusion of DA‐8159 resulted in the formation of three metabolites (M1–3). M1 was tentatively identified as hydroxy‐DA‐8159. M2 and M3 were identified as N‐demethyl‐DA‐8159 and 5‐(2‐propyloxy‐5‐aminosulphonylphenyl)‐1‐methyl‐3‐propyl‐1,6‐dihydro‐7H‐pyrazolo(4,3‐d)pyrimidin‐7‐one (DA‐8164), respectively, on the basis of LC‐MS/MS analysis with authentic standards. Rat CYP2D1 was a major isozyme for the formation of hydroxy‐DA‐8159 and N‐demethyl‐DA‐8159. CYP2C12 and CYP1A1 catalysed the oxidation of DA‐8159 to DA‐8164. Copyright © 2002 John Wiley & Sons, Ltd.
Export aspiration catheter thrombosuction before actual angioplasty in primary coronary intervention for acute myocardial infarction
Authors: Wang Huang‐Joe , Kao Hsien‐Li , Liau Chiau‐Suong , Lee Yuan‐Teh 
Published: October 2002

AbstractPrimary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in lesions with a large thrombus load increases the procedural complication rate. We describe a thrombus reduction technique in this setting using the Export aspiration catheter (EAC) for primary thrombosuction before actual angioplasty. The EAC is a component of the GuardWire Plus system (PercuSurge, Sunnyvale, CA), which was originally developed for emboli containment in saphenous vein graft and peripheral vessel interventions. Primary EAC thrombosuction was performed successfully in 12 patients undergoing primary PCI, and gross thrombi were obtained from 9 patients (75%). After definitive treatment with balloon angioplasty and/or stenting, TIMI 3 flow was restored in all target vessels. There was no angiographic evidence of distal branch loss or vessel injury. No major procedural or in‐hospital complication occurred in any patients. This primary EAC thrombosuction technique may offer a new, potentially effective method for thrombus burden reduction in treating AMI patients. Cathet Cardiovasc Intervent 2002;57:332–339. © 2002 Wiley‐Liss, Inc.
Comparison of early results of percutaneous metallic mitral commissurotome with Inoue balloon technique in patients with high mitral echocardiographic scores
Authors: Zaki Adel M. , Kasem Hussien H. , Bakhoum Sameh , Mokhtar Magdy , Nagar Wael El , White Christopher J. , Guindy Mohamed El 
Published: October 2002

AbstractWe compared the safety, efficacy, and cost of the newly introduced percutaneous metallic commissurotome (PMC) with the results of Inoue balloon mitral valvuloplasty (BMV) in 80 patients with mitral stenosis (MS). The mean increase in mitral valve area (MVA) was 0.95 ± 0.19 to 1.7 ± 0.35 cm2 for PMC and 0.97 ± 0.15 to 1.81 ± 0.36 cm2 for BMV (P = NS). The Wilkins echocardiographic scores before dilatation did not correlate with any difference in MVA after dilatation. Bilateral commissural splitting was significantly more common with PMC than with BMV (30/39 patients, 76.9%, vs. 21/40 patients, 52.5%; P = 0.02). Postprocedural severe mitral regurgitation occurred in 1/39 (2.6%) in the PMC group and in 4/41 (9.8%) in the BMV group. Because the PMC device is resterilizable, we estimated the cost to be one‐fourth the cost of BMV with the Inoue balloon. The estimated device cost ratio of PMC to BMV for each patient was 1 to 4.25. The early results of PMC on the MVA are comparable to BMV. However, PMC had better results not only in patients with high echocardiographic scores, but the PMC device splits commissural calcification better than BMV. Cathet Cardiovasc Intervent 2002;57:312–317. © 2002 Wiley‐Liss, Inc.
Coronary artery saddle embolus and myocardial infarction in a patient with prosthetic mitral valve
Authors: Aslam Mohammad Shakil , Sanghi Vinay , Hersh Steven , Lakier Jeffrey B. 
Published: October 2002

AbstractCoronary embolism is a rare cause of transmural myocardial infarction. A 58‐year old female with mechanical mitral valve prosthesis and chronic atrial fibrillation who presented with anterolateral myocardial infraction is described. The etiologies, diagnosis, treatment dilemma and various management options are discussed. Cathet Cardiovasc Intervent 2002;57:367–370. © 2002 Wiley‐Liss, Inc.
Plasma lidocaine concentrations after local anesthesia of the groin for cardiac catheterization
Authors: Guth Angelika , Hennen Benno , Krämer Thomas , Stoll Hans‐Peter , Böhm Michael 
Published: October 2002

AbstractThis study aimed to investigate serum lidocaine concentrations after subcutaneous infiltration of the groin for cardiac catheterization. One hundred twenty‐six patients for planned heart catheterization received five different dosages (5–25 ml) of lidocaine 2% for local anesthesia of the groin in a randomized manner. All of them received an arterial sheath and 13 received both an arterial sheath and a venous sheath for right heart catheterization. Blood samples were taken before as well as 15, 30, and 120 min after subcutaneous application of the drug. Although in 33 patients with an arterial sheath (no venous sheath) excessive doses of lidocaine 2% (20–25 ml) were used, neither symptoms of intoxication nor toxic plasma levels were observed. However, in patients receiving an additional venous sheath, toxic plasma levels were obtained in a third of the cases. One of them showed symptoms of intoxication. Cathet Cardiovasc Intervent 2002;57:342–345. © 2002 Wiley‐Liss, Inc.
A randomized prospective trial of ioxaglate 320 (Hexabrix) vs. iodixanol 320 (Visipaque) in patients undergoing percutaneous coronary intervention
Authors: Sutton Andrew G.C. , Ashton Victoria J. , Campbell Philip G. , Price Dallas J.A. , Hall James A. , de Belder Mark A. 
Published: October 2002

AbstractWe performed a randomized, prospective, double blind trial comparing the use of the ionic dimer contrast agent ioxaglate 320 (Hexabrix) with the nonionic dimer contrast agent iodixanol 320 (Visipaque) in 618 patients undergoing percutaneous coronary intervention (PCI) for stable or unstable coronary artery syndromes. The aim was to determine whether the different anticoagulant and antiplatelet properties of these two contrast agents resulted in a significant difference in the incidence of a combined endpoint comprising the major complications of PCI. Procedural success rates were marginally higher in the Visipaque group compared to the Hexabrix group, although this did not reach statistical significance (96.7% vs. 93.9%; P = 0.09). There was a borderline statistically significant higher requirement for bailout stenting in the Visipaque group compared to the Hexabrix group (6.8% vs. 3.2%; P = 0.05), although this was not a predefined endpoint. The incidence of the combined primary endpoint of failed catheter laboratory outcome/requirement for bailout stenting/requirement for abciximab/myocardial infarction/death before hospital discharge was higher in the Visipaque group compared to the Hexabrix group (17.9% vs. 14.8%), although this did not reach statistical significance (P = 0.29). When subgroup analysis was performed, the incidence of the combined endpoint in patients with stable coronary artery disease randomized to receive either Visipaque or Hexabrix was identical (13.7%). In patients with an acute coronary syndrome, there was a trend toward a reduced incidence of the combined endpoint in the Hexabrix compared to the Visipaque group, although this did not reach statistical significance (17.2% vs. 24.8%; P = 0.17). More adverse reactions occurred in the Hexabrix group compared to the Visipaque group (8.7% vs. 4.9%; P = 0.06). We conclude that there is no clear advantage with the use of an ionic contrast agent in a large population of patients undergoing PCI for both stable and unstable coronary artery disease. Although the study was underpowered to detect significant differences with the use of either agent when patients with either stable or unstable coronary disease were studied, it is highly unlikely that the ionicity of the contrast agent confers any advantage for patients with stable coronary disease. There remains a possibility that ionic agents do have advantages for patients with unstable coronary artery disease undergoing PCI, although a larger study than ours would be required to confirm or refute this. Cathet Cardiovasc Intervent 2002;57:346–352. © 2002 Wiley‐Liss, Inc.