bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia
Authors: Liu Jianguo , Geraghty Joseph R. , Schram Sarah , Cropper Haley C. , Lei Justin , Loeb Jeffrey A. , Song Fei 
Published: October 2023

AbstractPlaque formation, microglial activation, and synaptic loss are pathologic hallmarks of Alzheimer’s disease; however, removing plaques has had little clinical benefit. Here, we show that neuregulin-1, a glial growth factor, induces inflammatory cytokines and promotes phagocytic activityin vitroand augments microglial activation and plaque formation in 5XFAD Alzheimer’s mice. Brain-specific targeting of neuregulin-1 by intraventricular delivery of a novel neuregulin-1 fusion protein antagonist, GlyB4, significantly alters microglial morphology and function to a nonpathogenic morphology in early-stage 5XFAD mice and prevents plaques from forming. Once plaques have already formed, GlyB4 reduces new plaque formation and prevents synaptic loss. Selective, targeted disruption of neuregulin-1 signaling on brain microglia with GlyB4 could be a novel “upstream” approach to slow or stop disease progression in Alzheimer’s disease.
UVRAG cooperates with cargo receptors to assemble the ER‐phagy site
Authors: Qian Xuehong , He Lingang , Yang Jiejie , Sun Jiajia , Peng Xueying , Zhang Yuting , Mao Yizhou , Zhang Ying , Cui Yixian 
Published: October 2023

AbstractER‐phagy is a selective autophagy process that targets specific regions of the endoplasmic reticulum (ER) for removal via lysosomal degradation. During cellular stress induced by starvation, cargo receptors concentrate at distinct ER‐phagy sites (ERPHS) to recruit core autophagy proteins and initiate ER‐phagy. However, the molecular mechanism responsible for ERPHS formation remains unclear. In our study, we discovered that the autophagy regulator UV radiation Resistance‐Associated Gene (UVRAG) plays a crucial role in orchestrating the assembly of ERPHS. Upon starvation, UVRAG localizes to ERPHS and interacts with specific ER‐phagy cargo receptors, such as FAM134B, ATL3, and RTN3L. UVRAG regulates the oligomerization of cargo receptors and facilitates the recruitment of Atg8 family proteins. Consequently, UVRAG promotes efficient ERPHS assembly and turnover of both ER sheets and tubules. Importantly, UVRAG‐mediated ER‐phagy contributes to the clearance of pathogenic proinsulin aggregates. Remarkably, the involvement of UVRAG in ER‐phagy initiation is independent of its canonical function as a subunit of class III phosphatidylinositol 3‐kinase complex II.
Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity
Authors: Prekovic Stefan , Chalkiadakis Theofilos , Roest Merel , Roden Daniel , Lutz Catrin , Schuurman Karianne , Opdam Mark , Hoekman Liesbeth , Abbott Nina , Tesselaar Tanja , Wajahat Maliha , Dwyer Amy R , Mayayo‐Peralta Isabel , Gomez Gabriela , Altelaar Maarten , Beijersbergen Roderick , Győrffy Balázs , Young Leonie , Linn Sabine , Jonkers Jos , Tilley Wayne , Hickey Theresa , Vareslija Damir , Swarbrick Alexander , Zwart Wilbert 
Published: October 2023

AbstractGlucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate that GR relates to the proliferative capacity of numerous primary cancer types. In breast cancer, the GR activity status determines luminal subtype identity and has implications for patient outcomes. We reveal that GR engages with estrogen receptor (ER), leading to redistribution of ER on the chromatin. Notably, GR activation leads to upregulation of the ZBTB16 gene, encoding for a transcriptional repressor, which controls growth in ER‐positive breast cancer and associates with prognosis in luminal A patients. In relation to ZBTB16's repressive nature, GR activation leads to epigenetic remodeling and loss of histone acetylation at sites proximal to cancer‐driving genes. Based on these findings, epigenetic inhibitors reduce viability of ER‐positive breast cancer cells that display absence of GR activity. Our findings provide insights into how GR controls ER‐positive breast cancer growth and may have implications for patients' prognostication and provide novel therapeutic candidates for breast cancer treatment.
Antimicrobial veterinary drug sale pattern in correlation with critically important antimicrobials for human use: A five-year study in Montenegro
Authors: Mugoša Snežana , Vračar Vuk , Tešin Nadežda , Mitrović Jana , Tomanić Dragana , Kovačević Zorana 
Published: October 2023

AbstractAntimicrobial resistance (AMR) poses a significant threat in veterinary medicine due to the excessive and inappropriate use of antimicrobial agents, compromising the effectiveness of these drugs. To combat AMR, the collection of data on the consumption of antibiotics is paramount, as there is a well-established connection between antibiotic use and AMR in both humans and food-producing animals. Hence, the current study aimed to generate measurable data concerning the sales patterns of antimicrobial drugs used in animal treatment in Montenegro over a five-year period (from 2017 to 2021). Furthermore, the study aimed to compare these sales figures with the overall sales of antimicrobial veterinary medicine products (AMVMPs) during the same period, with particular emphasis on the utilization of critically important antimicrobials (CIAs) for human use. Data on AMVMPs consumption from 2017 to 2021 were expressed in euros and were sourced from the Institute for Medicines and Medical Devices of Montenegro (CInMED) annual reports, complying with the regulatory framework of the Law on Medicines in this country. Research results indicate that the sales of AMVMPs increased from 2017 to peak in 2019, followed by a stable decline of 21.79% in 2021. However, the portion of selected CIAs AMVMPs in total sales experienced a minor decline from 2017 to 2019, followed by a noticeable 6.11% increase from 2019 to 2021. In order to address AMR challenges, these findings emphasize the importance of enhancing surveillance and monitoring of veterinary antimicrobial use, as well as CIAs for human use.
Impact of pH adjustment on the characteristics of processed cheese from sheep milk and cow milk
Authors: Raimundi C.V. , Scopel B.C. , Ito A.N. , Tribst A.A.L. , Sehn G.A.R. , Cavalheiro D. , Rigo E. 
Published: October 2023

AbstractThe effects of milk from different species (sheep/cow) and pH adjustment in the production of Requeijão cremoso, a kind of processed cheese, were investigated. The results showed that the sheep's Requeijão cremoso had higher pH (∼3%), lower yellowness index (∼11%), and lower brightness (∼12%) after 5 days of storage, and at least 40% lower hardness compared to the Requeijão made from cow milk. The pH adjustment did not change the visual appearance of the samples but affected their hardness in different ways, with an increase of up to 16% for the cheese from cow milk and a reduction of up to 39% for the cheese produced from sheep milk. The results suggested that the protein-protein interactions were favoured in the Requeijão cremoso from sheep milk, while a protein network with higher water holding capacity and increased hardness was observed for the samples from cow milk.
Preventive effect of Lactobacillus plantarum YS1 isolated from naturally fermented yoghurt on carrageenan-induced thrombosis in mice
Authors: Wang M.-W. , She F. , Song J. , Liu Y.-Q. , Long X.–Y. , Zhao X. , Hong H.-Q. 
Published: October 2023

AbstractThis work used a carrageenan-based thrombosis model to determine the preventative effects of Lactobacillus plantarum YS1 (LPYS1) on thrombus. In thrombotic mice, LPYS1 improved the activated partial thromboplastin time (APTT), while decreasing the thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) content. In thrombotic mouse serum, LPYS1 decreased the levels of malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), nuclear factor kappa-B (NF-κB), and interleukin-1 beta (IL-1β), while also increasing the activities of superoxide dismutase (SOD) and catalase (CAT). Moreover, LPYS1 upregulated the mRNA expression levels of copper/zinc-SOD (Cu/Zn-SOD), manganese-SOD (Mn-SOD), and CAT in the colon tissues of thrombotic mice, while downregulating those of NF-κB p65, IL-6, TNF-α, and interferon-gamma (IFN-γ) mRNA. In tail vein vascular tissues, LPYS1 suppressed the mRNA expression levels of NF-κB p65, intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. The abundances of both beneficial and pathogenic bacteria were altered by LPYS1. These findings show that LPYS1 has the capacity to protect mice from thrombosis, while also revealing some of the underlying mechanisms of this effect.
Antecedentes Históricos del Diferendo Limítrofe Colombo Nicaragüense y de la Gestión de la Reserva Biósfera Seaflower
Authors: Álvarez Restrepo Julián Andrés 
Published: October 2023

Este artículo tiene como objetivo Identificar los antecedentes históricos de la controversia jurídica de delimitación marítima entre Colombia y Nicaragua, así como las problemáticas en la Gestión Ambiental de la Reserva Biosfera Seaflower, a partir del Método institucional de la Ciencia Política , que permite entender los antecedentes del diferendo limítrofe entre estos dos Estados más allá de los instrumentos de Derecho Internacional Público y de los Tratados Bilaterales que se celebraron en su momento para adjudicar la Soberanía sobre la Costa de Mosquitos a favor de Nicaragua y del Archipiélago de San Andrés Providencia y Santa Catalina a favor de Colombia. Así las cosas, este texto no se limita solo a la descripción de hechos históricos, sino que hace una hermenéutica de las relaciones de poder entre Colombia y Nicaragua y su disputa por el Archipiélago de San Andrés, Providencia y Santa Catalina, además se centra en la importancia ambiental del área marina protegida declarada Reserva Biósfera Seaflower por la UNESCO en el año 2000, permitiendo evidenciar como resultado y conclusiones que tanto Nicaragua como Colombia deben trascender de un asunto limítrofe a la creación de una Reserva Biósfera Transfronteriza de importancia para el Caribe y el mundo, a partir de la Estrategia de Sevilla + 20.
Progressive Muscle Relaxation: Can it Reduce Competitive Anxiety?
Authors: Jannah Miftakhul , Widohardhono Rachman , Kencana Navylia Tirta 
Published: October 2023

The study purpose was to determine the effect of progressive muscle relaxation training on reducing competitive anxiety among shooting athletes. Materials and methods. An experimental approach with a pretest-posttest control group design was used in this study. The experiment was carried out eight times. A total of 12 athletes, 8 males and 4 females, who were shooting athletes, took part in this research. The athletes in this study, who joined the regional training center in East Java Province, Indonesia, ranged in age from 20 to 44 years. In this investigation, saturated samples, including those from all individuals, were used. Data were obtained from competitive anxiety scales during the pre- and post-test periods. Independent samples t-tests were used to assess the data. Results. The t-value for this study is -14,210, and the p-value is 0.001. These findings suggest that progressive muscle relaxation training reduces competitive anxiety in shooting athletes. The athlete’s awareness of the value of mental training contributes to reduction in competitive anxiety. This study has gained traction since athletes are aware of the value of preparing for training before competing because they attend and participate in the regional training center. Conclusions. Progressive muscle relaxation training can be used as an intervention to help shooting athletes reduce their competitive anxiety.
Epidemiological aspects of the incidence and mortality of cervical cancer (literature review)
Authors: Kulieva G. Z. , Mkrtchyan L. S. , Krikunova L. I. , Ivanov S. A. , Kaprin A. D. 
Published: October 2023

A review of domestic and foreign literature was carried out. Statistical analysis of the available literature showed that at present, despite the improvement of screening programs around the world, there is a steady increase in the incidence and mortality of cervical cancer in women of reproductive age with a high percentage of patients with advanced forms, whose proportion is 32 %. The percentage of deaths during the year since the verification of the disease in 2020 was 12.6 %.In the structure of mortality in the Russian population, malignant diseases occupy the second ranking place, accounting for 13.6 % after diseases of the cardiovascular system – 43.9 %. Diseases of the female reproductive system account for 18.2 %. At the same time, cervical cancer in the overall structure of oncological morbidity occupies the 4th ranking place, and among the organs of the reproductive system – the 2nd place – 13.3 %, yielding to breast cancer (47.8 %). These figures reflect the lack of implemented programs aimed at reducing the incidence of cervical cancer.
A clinico-histopathological study of skin appendageal tumours in a tertiary health care centre in western Odisha– A case series
Authors: Mishra Pragnya P. , Sahu Puspanjali , Panigrahi Sarita , Hota Smruti Ranjan , Kumari Priya , Panda Premanand 
Published: October 2023

Skin appendageal tumours (SATs) are those neoplasms that arise from pilosebaceous, apocrine, or eccrine sweat glands. These are a diverse group of tumours with both benign and malignant counterparts. They can be single, multiple, or have a syndromic association with internal malignancies. Benign adnexal tumours are more common, while malignant adnexal tumours are rare, usually locally aggressive, and have the potential for nodal involvement and distant metastasis with a poor clinical outcome. Therefore, proper diagnosis of SATs is important for therapeutic and prognostic reasons.This study aims to determine the clinico-histopathological correlation in cases of SATs in our hospital. It is a case series conducted over a one-and-a-half year period from January 2021 to July 2022. All clinically suspected cases of SATs were examined, biopsied, and subjected to histopathological examination. Histopathologically confirmed cases of SATs were finally analysed. Among twenty-four thousand two hundred twenty-four new patients attending OPD, 30 suspected cases of ATs underwent histopathological examination. Histopathology was confirmatory in only 12 cases (40%). 10 cases were benign, and two were malignant. Out of 10 benign cases, hidradenoma was noted in 3 (25%), trichoepithelioma in 2 (16%), proliferating pilar tumour, apocrine hidrocystoma, steatocystoma multiplex, hidradenoma papilliferum, and pilomatrixoma were seen in one each. Females (75%) outnumbered males (25%) in our study population.: SATs are infrequent and are not frequently observed in the field of surgical pathology. Histopathology is the gold standard for diagnosis.
Diagnostic Value of Serum Procalcitonin and Diastolic Dysfunction for Evaluating the Mortality of Sepsis Patients Admitted in the Intensive Care
Authors: Hejazi Mohammad Esmaeil , Takaldani Ali Hossein Samadi , Ranjbar Abdolmohammad , Negaresh Mohammad 
Published: October 2023

Background: Sepsis is a serious condition that can be fatal and has become more common in recent times. The impact of diastolic dysfunction on the early mortality rate of septic patients has not been extensively researched. This study aimed to assess the accuracy of serum procalcitonin (PCT) levels and diastolic dysfunction in predicting the mortality rate of patients diagnosed with sepsis and admitted to the intensive care unit.
Methods: In this cross-sectional study, 40 sepsis patients admitted to the ICU were examined. Their characteristics were meticulously recorded using the APACHE II and SOFA score questionnaires, and only those who met the criteria underwent echocardiography. In order to evaluate the serum levels of PCT, it was required to take 40 ml of venous blood samples from the patients on the first and fifth days of admission.
Results: Out of 40 patients, the average age was 63±17 years. Of these patients, 23 (57.5%) were discharged, while 17 (42.5%) unfortunately passed away. Results showed a notable correlation between diastolic dysfunction, CRP, SOFA score on days 1 and 2, APACHE II score, and PCT on day 5 (P˂0.05). However, when analyzed using logistic regression, only PCT on day 5 showed a significant association with mortality.
Conclusion: Based on our research, we found that PCT is an essential indicator in predicting the mortality rate of sepsis patients. While there was no significant correlation between diastolic dysfunction and mortality, it should still be considered a critical factor in determining the mortality rate.
The Comparison of Deep Sedation and Moderate Sedation in Pneumatic Balloon Dilation of Achalasia Patients
Authors: Mikaeli Javad , Fazlollahi Narges , Khajehnasiri Alireza , Tamartash Zahra , Atef-Yekta Reza 
Published: October 2023

Background: Pneumatic Balloon Dilation (PBD) as an achalasia treatment is painful procedure because of tearing the lower esophageal sphincter (LES) muscle fibres. Recently, two sedation methods including the moderate sedation and deep sedation are used for increasing the convenience of the patients and gastroenterologist.
Methods: To compare the efficacy of moderate and deep sedation in PBD in treatment of Idiopathic Achalasia (IA).
Results: We prospectively assessed 200 IA patients. The first 100 patients (group A) underwent PBD by the moderate sedation using diazepam or midazolam and meperidine injections. The patients in the group B (100 patients) received midazolam, fentanyl and propofol as a deep sedation. The pulse rate (PR), systolic and diastolic blood pressure (SBP, DBP), respiratory rate (RR), and oxygen saturation were monitored before, during and after PBD and achalasia symptom scores (ASS) were collected before and 1.5 months after treatment. The mean PR during and after procedures in the group B were significantly lower compared to the group A (p 0.001, 0.028). The patients in group B revealed less SBP and DBP after PBD versus group A (p 0.004, 0.002). The mean psi for 30 mm and 35 mm balloon dilators were significantly increased in group B compared to group (p 0.0001, 0.002).
Conclusion: We concluded that the deep sedation of achalasia patients in the PBD process can improved the efficacy of PBD and decreased the complications (transient chest pain) of the procedures. The patients with the deep sedation revealed less tachycardia and blood pressure rising and tolerated more pressure in balloon dilators.
An examination of supporting structures for postgraduate students’ completion of research projects at one of the universities in South Africa
Authors: Mashau Takalani Samuel , Ravhuhali Fhatuwani  
Published: October 2023

The Council on Higher Education (CHE)’s report on the doctoral programme review states that offering postgraduate programmes seems to be a challenge to some South African universities. Amongst others, the report expresses that postgraduate supervision at universities suffers from many challenges, some of which result in students being delayed or not completing their studies. Underpinned by Archer’s (1998) theory of the interplay between structure, culture, and agency (support programmes), the study seeks to examine factors that hinder postgraduate students’ completion of their dissertations and theses. The study adopted narrative research where the qualitative design was used. Postgraduate students (Master and Doctoral) who have registered for these programmes repeatedly in the university served as participants in the study. The purposive sample was used to sample eight postgraduate students who have frequently registered for more than the required residency period. Semi-structured questions were formulated to guide data collection. Data was collected through a focus group of eight Master and Doctoral students. Collected data were analysed using the content analysis method. The study found that the university does not have adequate (or weak) supporting structures for students to complete their degrees in record time.
Lithospheric Structure and Extensional Style of the Red Sea Rift Segments
Authors: Sreenidhi Kuruvamana Satheeshbabu , Radhakrishna Munukutla , Betts Peter G. 
Published: October 2023

Abstract
The Red Sea provides an opportunity to study the processes during the transition from continental rifting to early-stage seafloor spreading during ocean initiation. We delineate variations of lithospheric architecture and the nature of extension along the Red Sea region through joint interpretation of gravity and geoid anomalies and gravity-topography transfer functions. We use lithospheric-scale models to compare stretching factors with upper mantle gravity anomaly, residual mantle Bouguer anomaly, and effective elastic thickness. Based on our observations, the Red Sea is divided into four segments; each having distinct lithospheric characteristics and stretching styles. These are: (i) southernmost Red Sea and Danakil having regionally weak and stretched lithosphere, (ii) southern Red Sea with fully developed seafloor spreading and asymmetric lithospheric architecture, (iii) central Red Sea having discontinuous magma accretion with newly formed seafloor spreading, and (iv) northern Red sea with a stronger lithosphere and limited stretching revealing a stage of continental rifting. In these segments, lithospheric stretching correlates with regions of weak lithosphere, including a regime of sublithospheric plume channel beneath the southern Red Sea. The Zabargad fracture zone between the central and northern segments is revealed as a major lithosphere-scale boundary that may act as a barrier to the propagation of seafloor spreading into the northern Red Sea. The weak and highly stretched lithosphere in this region may indicate the onset of a new spreading cell. Our results conclude that the evolution of the Red Sea is more complex than the previously suggested kinematic models of simple “unzipping” and illustrate that several extensional styles can exist within different segments during the initial stages of ocean formation.