bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative chemotherapy versus adjuvant chemotherapy treatment for resectable locally advanced gastric cancer: a retrospective cohort study
Authors: Su Pengfei , Jiang Lin , Zhang Yingjing , Yu Tian , Huang Hongyun , Chen Moxi , Cao Can , Kang Weiming , Liu Yuqin , Yu Jianchun 
Published: October 2023

Abstract
Background
Neoadjuvant chemotherapy (NAC) is increasingly used in locally advanced gastric cancer (LAGC), but the clinical safety and efficacy are still controversial. This study aims to compare perioperative chemotherapy (PEC) with adjuvant chemotherapy (AC) for resectable LAGC.

Methods
Patients who underwent D2 gastrectomy for resectable LAGC were retrospectively reviewed, and divided into NSA group (NAC plus surgery and AC) and SA group (surgery followed by AC). The baseline characteristics and perioperative data were compared. Survival analysis was based on Kaplan–Meier method. Multivariate analyses for prognostic factors were based on the Cox regression.

Results
A total of 450 patients were eligible for this study. 218 patients received NAC plus surgery and AC, while 232 upfront surgery followed by AC. The baseline characteristics were comparable between the two groups. NSA group showed significant superiority in R0 resection rate (P = 0.014), excised tumor size (P = 0.038), and tumor downstage (all P < 0.001). NAC did not affect postoperative complications or AC-related grade 3/4 adverse events. Patients in NSA group achieved significantly longer OS (P = 0.021) and DFS (P = 0.002). The Cox regression model showed that NAC was independently associated with better OS (HR 0.245, P = 0.039) and DFS (HR 0.591, P = 0.031).

Conclusions
Compared with SA, the administration of NSA was considered safe and feasible for achieving higher R0 resection rate without increasing the postoperative complications or AC-related grade 3/4 adverse events, and NAC was independently associated with better OS and DFS for resectable LAGC.
Sustainability of community-based workers in multisectoral food security programs: a case study of producer leaders, village vaccinators, mother leaders, and community health workers in Burkina Faso
Authors: Wilson K. R. , Rogers B. L. , Carroll D. A. , Ezaki A. , Coates J. 
Published: October 2023

AbstractThe community-based worker (CBW) model is commonly used by food security projects as an approach to catalyze community-driven development and to enhance long-term sustainability of project impacts in rural areas of low-income countries. However, there is limited follow-up research exploring how CBWs continue to carry out expected activities in the years that follow project exit. This case study examines how four different CBW roles—producer leaders, village vaccinators, community healthcare workers, mother leaders—all trained to contribute to the food security goals of a multi-year initiative in Kaya, Burkina Faso, sustained their respective activities post-project. Two years after the project ended, we collected qualitative data to examine how well these CBWs continued providing the activities that they had been trained to provide as expected by the project. We employ a conceptual framework of sustainability and exit strategies to assess what factors contributed to sustained activities and, where activities ceased, what caused them to stop. We find that where activities were sustained, all four hypothesized factors—sustained capacities, resources, motivation, and linkages—were present. We conclude by discussing key lessons and considerations for using the CBW model: (1) gradually transition to independent operation during project lifetime; (2) integrate CBWs into permanent and functional systems through gradual project exit; (3) professionalize the CBW role (re-think the volunteer approach); (4) what to do about resources and (5) co-develop endogenous definitions and indicators from the project onset.
Experimental Study on Effect of Recycled Reinforced Concrete Waste on Mechanical Properties and Structural behaviour of the Sandy Soil
Authors: Basha Ali , khalifa Fatma , Fayed Sabry 
Published: October 2023

AbstractIn recent years, constructing natural aggregates as a base layer for the roads has increased. Natural resources will run out as long as human consumption of them continues. Recycled concrete aggregate (RC) has thus emerged as a substitute material for the building of road base layers. Additionally, RC can be utilized to create interior city highways. The base layer for roads must have sufficient strength to support the working load on the pavement surface without damage deforming. As a result, the focus of this paper is on enhancing the structural performance of sandy soil reinforced with various RC percentages. The three key factors are relative soil density (Dr = 83 and 97%), recycled concrete aggregate reinforcing levels (RC = 0,5,10,15,20,25,30,40,50 and 100%), and reinforcement layer thickness (Rd = 0.0B, 0.5B, B, and 2B where B is the footing model width). Numerous laboratory experiments were conducted in order to examine the impact of important parameters on the properties of the mixtures. The plate bearing tests were carried out using a footing model (250 × 250 mm) inside a tank (1500 × 1500x1000 mm) to ascertain the stress–strain response, bearing capacity ratio (BCR), ultimate bearing capacity, and modulus of elasticity of the tested mixtures. It is clear that raising the RC has no effect on the diameters of the grains. It was found that as RC increased, the mixture's bulk density increased but specific gravity decreased. Maximum dry density rose as RC rose, whereas water content fell. It was noted that BCR unquestionably increased as RC increased for all RC levels and all values of settlement ratios. The appropriate reinforcing layer thickness is suggested to be no more than 2B. As the RC concentration in the sand and Rd increased, the difference between two pressure-settlement curves of densities 83% and 97% significantly decreased. Furthermore, when RC reaches 50%, two curves are roughly comparable. At RC = 50%, it is advised that the relative density of 83% is sufficient to produce the same behavior as the relative density of 97%. It was found that as RC and Rd grew, the tested mixtures' ultimate bearing capacity and elasticity modulus increased as well. A novel proposed formulas are developed to compute bearing capacity ratio, ultimate bearing capacity, and elasticity modulus of the tested mixtures taking into account the influence of RC, reinforcement layer depth, settlement ratio, and the relative density, and its results agree with the experimental results.
A cell transcriptomic profile provides insights into adipocytes of porcine mammary gland across development
Authors: Fan Yongliang , Jin Long , He Zhiping , Wei Tiantian , Luo Tingting , Zhang Jiaman , Liu Can , Dai Changjiu , A Chao , Liang Yan , Tao Xuan , Lv Xuebin , Gu Yiren , Li Mingzhou 
Published: October 2023

Abstract
Background
Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring adipocytes.

Results
Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from physiological mammary glands across five developmental stages (d 90 of gestation, G90; d 0 after lactation, L0; d 20 after lactation, L20; 2 d post natural involution, PI2; 7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation (G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation (L0 and L20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution (PI2 and PI7), epithelial cell populations dedifferentiate into mesenchymal stem cells to maintain the lactation potential of mammary glands for the next lactation cycle.

Conclusion
The molecular mechanisms of dedifferentiation, proliferation and redifferentiation of adipocytes and epithelial cells were revealed from late pregnancy to natural involution. This cell transcriptomic profile constitutes an essential reference for future studies in the development and remodeling of the mammary gland at different stages.
The role of stigma and depression in the reduced adherence among young breast cancer patients in Hungary
Authors: Vizin Gabriella , Szekeres Tamás , Juhász Anita , Márton Lilla , Dank Magdolna , Perczel-Forintos Dóra , Urbán Róbert 
Published: October 2023

Abstract
Background
The main aim of our study was to investigate the role of depression, stigmatization, body shame and self-compassion in the adherence of young Hungarian breast cancer patients aged between 18 and 45 years.

Methods
In a cross-sectional online survey, data were collected from 99 young breast cancer patients (BC). Participants completed self-report questionnaires on socio-demographic and cancer-specific parameters as well as psychological factors (adherence: 12-item Medication Adherence Scale; depression: Hospital Anxiety and Depression Scale; stigmatization: Stigma Scale for Chronic Illnesses; body shame: Experience of Shame Scale; self-compassion: Self-Compassion Scale). We tested the predictors and mediators of adherence using hierarchical regression, mediation and moderation analysis among BC patients.

Results
We found that adherence was significantly associated with body shame and stigmatization in our BC sample. In addition, stigmatization alone was a significant predictor of lower adherence. Finally, in mediation models, where body shame was a mediator, we found a significant direct effect between stigma and adherence, in other words body shame had a significant mediating effect between these variables. According to our moderation analysis, self-compassion as a significant moderator acts as a protective factor in the linear relationship between stigma and lower adherence.

Conclusions
Our results highlight the importance of stigma and body shame in the development of adherence in oncological care among young Hungarian BC patients aged between 18 and 45 years. Assessment of stigma, body shame, self-compassion, and the improvement of the availability of evidence-based psychological interventions may increase the adherence of young Hungarian BC patients, leading to more favourable rates of survival.
Expressed breast milk and maternal expression of breast milk for the prevention and treatment of neonatal hypoglycemia: a systematic review and meta-analysis
Authors: Oladimeji Oluwatoyin Ibukun , Harding Jane E , Crowther Caroline A , Lin Luling 
Published: October 2023

Abstract
Background
Worldwide, many guidelines recommend the use of expressed breast milk (EBM) and maternal expression of breast milk for the prevention and treatment of neonatal hypoglycemia. However, the impact of both practices on neonatal hypoglycemia is unclear. This study aims to determine the effectiveness of EBM and maternal expression of breast milk in preventing and treating neonatal hypoglycemia.

Methods
We registered our review in PROSPERO (CRD42022328072). We systematically reviewed five databases and four clinical trial registries to identify randomized controlled trials (RCT), non-randomized studies of intervention (NRSI), and cohort studies that compared infants who received EBM to infants who did not, and similar study designs that compared infants whose mothers expressed breast milk to infants whose mothers did not. Two independent reviewers carried out screening, data extraction, and quality assessment. The quality of included RCT, NRSI, and cohort studies were respectively assessed with the Cochrane Risk of Bias 2, Risk Of Bias In Non-randomised Studies—of Interventions, and the Newcastle–Ottawa Scale tools. Results from studies on EBM were synthesized separately from those on maternal expression of breast milk. Meta-analysis was undertaken using Revman 5.4. and fixed-effect models.

Results
None of the ten included studies was specifically designed to determine the effect of EBM or maternal expression of breast milk on neonatal hypoglycemia. The effect of EBM on neonatal hypoglycemia was not estimable. There was no difference in the risk of hypoglycaemia among neonates whose mothers expressed breast milk compared to those whose mothers did not [RR (95%CI); one RCT: 0.92 (0.77, 1.10), high-certainty evidence; one cohort: 1.10 (0.74, 1.39), poor quality study].

Conclusions
There is insufficient evidence to determine the effectiveness of EBM for preventing or treating neonatal hypoglycemia. Limited data suggests maternal breast milk expression may not alter the risk of neonatal hypoglycemia. High-quality randomized controlled trials are needed to determine the effectiveness of EBM and maternal expression of breast milk for the prevention and treatment of neonatal hypoglycemia.
Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
Authors: Negishi Daisuke , Mitsumatsu Okimichi , Mitsumatsu Hiromi , Makiguchi Miaki , Shimizu Makiko , Yamazaki Hiroshi 
Published: October 2023

Abstract
Background
Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species.

Case presentation
Two patients with osteoarthritis (women aged 79 and 73 years, cases 1 and 2, respectively) infected with S. aureus were successfully treated with tedizolid after administration of 200 mg once daily via intravenous infusion. The synovial fluid and plasma concentrations of tedizolid during surgery in case 1 at day 7 were 2.1 and 1.6 µg/mL, respectively, yielding a ratio of synovial fluid/plasma of 130%. Those in case 2 at day 2 were 2.9 and 3.3 µg/mL, respectively, corresponding to a ratio of synovial fluid/plasma of 88%.

Conclusions
These results imply very similar concentrations of tedizolid in the synovial fluid and plasma of osteoarthritis patients with acute S. aureus infection.
The progestin revolution 2: progestins are now a dominant player in the tight interlink between contraceptive protection and bleeding control—plus more
Authors: Shoupe Donna 
Published: October 2023

AbstractThe interlink between bleeding control and contraceptive development has always been an important factor. But after many years of advances in contraceptive technology, this interplay has resulted in development of safer and better contraceptive methods that often offer significantly less bleeding for women with both normal bleeding patterns as well as in those suffering from heavy menstrual bleeding (HMB). Recognition of the success of progestin-only methods, such as the hormonal IUDs, progestin dominant oral contraceptives, and the high dose progestin-only pill in substantially decreasing and controlling menstrual bleeding has led the way. This recognition also led to the development of many [non-contraceptive] protocols to stop acute heavy bleeding as well as manage long-term bleeding [using contraceptive methods as well; as non-contraceptive methods].But even better, there is a new PLUS. The distinct benefit and risk profiles of the many different progestins now available are intentionally being used either in combination contraceptive pills [COCPs] or alone, to add additional benefits, to decrease side effects and risks, and increase effectiveness and bleeding control.
Socio-psychological integration from the perspective of receiving communities: a cross-country comparison between Sweden, Germany, Croatia and Jordan
Authors: Kiralj Lacković Jana , Ajduković Dean , Abdel-Fatah Dana , Hertner Laura , Alkhatib Walid 
Published: October 2023

AbstractThe socio-psychological dimension of integration is based on relations between the refugees and receiving community members revealed through intergroup thoughts, perceptions, emotions and behaviours. This study aimed to investigate and interpret the differences in the indicators of socio-psychological integration among the receiving communities of Sweden, Germany, Croatia and Jordan—countries with diverse socio-economic, socio-political and cultural contexts, histories of inward migration, as well as differently preferred destinations in the migration of refugees from Syria in the 2010s. The contextual differences are reflected in the attitudes of the members of receiving communities towards refugees from Syria, perceptions of realistic and symbolic threats posed by refugees, frequency and valence of intergroup contact, support for the rights of refugees and readiness to assist them, social proximity, perception of refugees’ exposure to discrimination, and the assessment of how much the refugees are a part of the respective local communities.
Safety and efficacy of biological agents in the treatment of Systemic Lupus Erythematosus (SLE)
Authors: Chan Justin , Walters Giles D. , Puri Prianka , Jiang Simon H. 
Published: October 2023

Abstract
Background
To determine the safety and efficacy of biological agents used in the treatment of systemic lupus erythematosus (SLE) in adults.

Methods
Systematic review and meta-analysis following PRISMA guidelines.

Data sources
MEDLINE (through Pubmed), EMBASE, Cochrane library, Clinicaltrials.gov, Australianclinicaltrials.gov.au, ANZCTR.org.au and WHO International Clinical Trials Registry Platform for studies published from 20 May 2021 and 15 years prior. A grey literature search was performed and completed on 31 May 2021.

Study criteria
Phase II, III or quasi randomised controlled trials, studies with only cerebral or cutaneous lupus were excluded. Data extraction: Two authors independently screened studies for eligibility, extracted, reviewed data for accuracy, and used the Cochrane tool to assess risk of bias.

Results
Forty-four studies were identified, consisting of 15 groups of drugs and 25 different biological agents, totalling 16,889 patients. The main outcomes assessed included Systemic Lupus Erythematosus Responder Index (SRI), BILAG-Based Composite Lupus Assessment (BICLA) and combined combined/partial renal remission (CRR/PRR).
Four groups of biologics were found to improve outcomes. Anti-interferons: Anifrolumab increased BICLA response and SRI 5 to 8, decreased prednisone dosages, with increased herpes zoster infections, but fewer serious adverse events. Sifalimumab improved SRI but also increased herpes zoster infections. Anti BAFF/BLyS and/or APRIL: Belimumab consistently improved SRI 4, decreased prednisone dosages, increased combined CRR/PRR, and had no adverse safety outcomes. Tabalumab increased SRI 5 at 52 weeks with no steroid sparing effect but was associated with increased infusion related adverse events. Telitacicept improved SRI 4 at 52 weeks, with no increased adverse events, though data was rather sparse. Anti CD-20 monoclonal antibody, Obinutuzumab increased combined CRR/PRR at 1 and 2 years. Anti IL12/23 monoclonal antibody, Ustekinumab, increased SRI 4 to 6, but not BICLA at 24 weeks, with no concerning safety outcomes.

Conclusion
Multiple biologic agents are shown in high quality studies to have a significant therapeutic impact on outcomes in SLE.
The rising burden of chronic kidney diseases in patients with diabetes
Authors: Almomani Ensaf Y. , Almomani Huda Y. , Al-Azzam Sayer , Qablan Ahmad , Al-Momany Abass 
Published: October 2023

Abstract
Background
The prevalence of chronic kidney diseases (CKD) is higher in patients with diabetes. The American diabetes association (ADA) provides components of diabetes care, treatments, and guidelines to diagnose diabetic patients at risk of CKD. Herein we followed the ADA diagnosis guidelines to identify the Type 2 Diabetes mellitus (T2DM) patients at risk of CKD which is underestimated in the region. The study main objectives are to investigate the CKD prevalence and association with risk factors according to the ADA classification, and also to identify the T2DM patients at risk of renal diseases. A descriptive retrospective study was conducted. The data were collected using face-to-face interviews and through accessing patients’ medical records from Endocrinology and Cardiology clinics in an academic tertiary care hospital.

Results
About 40% of the 331 T2DM outpatients were at risk of developing CKD. The majority were in CKD Stage 3, then Stage 2. The estimated GFR (eGFR) values were significantly reduced in the T2DM patients who are; older than 50 years; have diabetes for more than 10 years; and have abnormally high serum and urine creatinine, proteinuria, and albumin to creatinine ratio. Further, the eGFR values were negatively associated with; the duration of T2DM; serum creatinine, proteinuria; and albumin to creatinine ratio.

Conclusions
This study provides evidence of the increasing risk of CKD among T2DM patients in the region. Hence, T2DM patients especially elders and those with the long onset of diabetes need to go under regular checks on their clinical parameters to prevent CKD progression.