bluuebunny/crossref_metadata_2025_split huggingface dataset:
How does heritage contribute to inclusive growth?
Authors: Dorpalen Brenda Denise , Gallou Eirini 
Published: November 2023

PurposeThe first objective of this article is to analyse the reasons to pursue inclusive growth, that is economic growth accompanied by a reduction of social inequalities in different dimensions. The second objective of the article is to develop a systematised framework to understand the different channels and enablers by which heritage can contribute to inclusive growth through a review of specialised literature.Design/methodology/approachThe methodology of this article is based on an exhaustive review of existing literature around models of economic development and their ability to decrease social inequalities. It critically reviews theoretical and empirical studies on existing economic approaches and links them with the heritage policy field.FindingsThe article finds that countries should pursue inclusive development since it is a fundamental condition for social cohesion, trust and society's overall well-being and because it enables economic growth to be sustainable through time. It also identifies four channels through which heritage can contribute to inclusive development: in its public good dimension, in its capacity to equalise opportunities, in its ability to reduce social, educational and health disparities and in its capacity to decrease spatial income inequalities through regeneration processes.Research limitations/implicationsThe framework, that is developed to categorise the different channels and enablers through which heritage could contribute to inclusive growth, is not empirically tested. Further research could approach this by estimating a difference in difference model. However, data limitations could limit this objective in the short-term.Originality/valueIts originality relies in the development of a conceptual framework that is aimed at shaping heritage policies that target, at the same time, the reduction of inequalities and economic growth.
Quality and selling format choices in a supply chain considering remanufacturing competition
Authors: Zhang Wen , Dai Mingzhuo 
Published: November 2023

PurposeThe purpose of this study is to explore the interplay between the selection of selling formats of remanufactured products for a third-party remanufacturer (TPR) and the quality decision of an original equipment manufacturer (OEM).Design/methodology/approachThis study considers a remanufacturing supply chain, where the OEM sells new products through a platform retailer, but the products remanufactured by the TPR can be sold via a direct or indirect channel. The authors model a Stackelberg game and explore the optimal quality decision of the OEM and selling format choice of the TPR.FindingsThe OEM's optimal decision depends mainly on consumers' discounted utility coefficient and cost-scale factor of remanufactured products. A higher consumers' valuation of the remanufactured product will not result in a higher retail price, but may lead to an increase in new product's sales. Given the cost-scale factor, the TPR prefers to sell directly no matter what the value of consumers' discounted utility coefficient is. An all-win situation is achieved with selling directly when consumers' discounted utility coefficient is sufficiently large.Practical implicationsThese results provide some support to the operational strategies of the OEM and TPR.Originality/valueThis study firstly endogenizes the quality decision and combines the selling format selection of the TPR and the quality decision of the OEM to explore the interplay between these two important decisions.
Entropic behavior in bidirectional flow of CeO2-ZnO/water hybrid nanofluid with prescribed surface temperature/heat flux aspects
Authors: Faisal Muhammad , Ahmad Iftikhar , Rashid Abdur 
Published: November 2023

PurposeThe present study aims to encompass the bidirectional magnetized flowing of a hybrid-nanofluid over an unsteady stretching device with the inclusion of thermal radiation and entropy generation. Brick-shaped nanoparticles (zinc-oxide and ceria) are suspended in water, serving as the base-fluid to observe the performance of the hybrid mixture. The Maxwell thermal conductivity relation is employed to link the thermophysical attributes of the hybrid mixture with the host liquid. Additionally, a heat source/sink term is incorporated in the energy balance to enhance the impact of the investigation. Both prescribed-surface-temperature (PST) and prescribed-heat-flux (PHF) conditions are applied to inspect the thermal performance of the hybrid nanofluid.Design/methodology/approachThe transport equations in Cartesian configuration are transformed into ordinary differential equations (ODEs), and an efficient method, namely the Keller-Box method (KBM), is utilized to solve the transformed system. Postprocessing is conducted to visually represent the velocity profile, thermal distribution, skin-friction coefficients, Bejan number, Nusselt number and entropy generation function against the variations of the involved parameters.FindingsIt is observed that more entropy is generated due to the increases in temperature difference and radiation parameters. The Bejan number initially declines but then improves with higher estimations of unsteadiness and Hartmann number. Overall, the thermal performance of the system is developed for the PST scenario than the PHF scenario for different estimations of the involved constraints.Originality/valueTo the best of the authors' knowledge, no investigation has been reported yet that explains the bidirectional flow of a CeO2-ZnO/water hybrid nanofluid with the combined effects of prescribed thermal aspects (PST and PHF) and entropy generation.
Centering justice/decentering whiteness: the case for abolition in information literacy pedagogical praxis
Authors: Moreno Teresa Helena 
Published: November 2023

PurposeThe purpose of this paper is to make visible the field's propensity to center whiteness even in engaging inclusive practices in information literacy classrooms. This paper offers abolitionist pedagogy as a means to understand and address these concerns.Design/methodology/approachThis paper uses interdisciplinary research methods in the fields of education, library science, feminist studies, Black studies and abolition studies to examine and provide an analysis of current information literacy practices by using abolitionist pedagogy to articulate how it is possible to expand information literacy instruction practices.FindingsCurrent information literacy practices and methods that seek to create inclusive learning environments for racialized and minoritized learners rely on a set of institutionalized practices such as critical information literacy and culturally sustaining pedagogies. An examination of these practices through an abolitionist pedagogical lens reveals how the field has engaged in reductive and uncritical engagement with these methods despite employing them to create inclusive spaces. Using abolitionist pedagogy as a lens, this critical essay examines the field's foundations in whiteness and illustrates pathways for transformative educational justice.Originality/valueThere has been much work on inclusive teaching practices that discusses challenging information literacy structures' reliance on dominant culture.? To date, there has been little to no scholarship on how information literacy practices could engage in abolitionist pedagogical praxis.
Anti‐immunoglobulin E provides an additional therapy to conventional steroids for Kimura's disease
Authors: Ao Suiting , Huang Gege , Tang Xuhua , Zhu Zhe , Han Jiande , Wang Fang , Zhai Wanying 
Published: November 2023

AbstractKimura's disease (KD) is a chronic inflammatory disease characterized by painless subcutaneous head and neck swelling, eosinophilia, and elevated serum immunoglobulin (Ig) E levels. There are various therapies, including surgery, radiation, systemic steroids, and immune suppressants, but their efficacy remains moderate due to the high recurrence rate. Biologics, like monoclonal antibodies, have shown tremendous effectiveness for chronic inflammatory diseases. Omalizumab is a monoclonal antibody against IgE and has not been approved for KD so far. We describe two refractory KD cases that responded to a small dose of steroids plus omalizumab. Additionally, we reviewed another 13 KD cases that were treated with biologics, including omalizumab, rituximab, dupilumab, and mepolizumab. The results indicate that biologics provide an alternative treatment strategy for KD.
Agomelatine alleviates steroid‐induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats
Authors: El‐Mahroky Samaa M. , Nageeb Mahitab M. , Hemead Dalia A. , Abd Allah Enas G. 
Published: November 2023

AbstractOne of the major contributors to secondary osteoporosis is long‐term glucocorticoid usage. Clinically used antidepressant agomelatine also has anti‐inflammatory properties. Our research aimed to inspect the probable defensive effect of agomelatine against steroid‐promoted osteoporosis. There were four groups of rats; group I had saline as a negative control; rats of group II had dexamethasone (0.6 mg/kg, s.c.), twice weekly for 12 weeks; rats of group III had agomelatine (40 mg/kg/day, orally), as a positive control, daily for 12 weeks; and rats of group IV had dexamethasone + agomelatine in the same previous doses combined for 12 weeks. Finally, biochemical as well as histopathological changes were evaluated and dexamethasone treatment caused osteoporosis, as evidenced by discontinuous thin cancellous bone trabeculae, minor fissures and fractures, irregular eroded endosteal surface with elevated alkaline phosphate, tartarate resistant acid phosphate (TRACP) and osteocalcin levels. Osteoprotegerin (OPG), calcium, and phosphorus levels decreased with disturbed receptor activator of nuclear factor κ B ligand (RANKL), forkhead box O1 (FOXO1), and silent information regulator 1 (SIRT1) protein expression. However, treatment with agomelatine restored the normal levels of biochemical parameters to a great extent, supported by SIRT activation with an improvement in histopathological changes. Here, we concluded that agomelatine ameliorates steroid‐induced osteoporosis through a SIRT1/RANKL/FOXO1/OPG‐dependent pathway.
Drinking water under fire: Water utilities' vulnerability to wildfires in the Pacific Northwest
Authors: Robichaud Patrick J. L. , Padowski Julie C. 
Published: November 2023

AbstractIncreased wildfire activity in the western United States can lead to detrimental cascading effects to water quality. After fires, burned areas may experience significant runoff‐induced erosion and sediment transport into rivers and reservoirs, which could rapidly overwhelm existing drinking water treatment plants. This paper couples an assessment of wildfire risk with an evaluation of water utility preparedness to understand where key fire‐related drinking water vulnerabilities exist. Wildfire risk assessments were constructed and expanded from a commonly used methodology co‐developed between researchers and water managers (Edel et al., 2002), to understand drinking water impacts on water quality after wildfires. A water utility preparedness index was created for this study using publicly available information to contextualize how well utilities may be able to respond to water quality degradation after fires. Results indicate that 22% of utilities studied (10% of the population served) were underprepared for fire and 11% of watersheds used were at greater risk of wildfire (9% of the population served). However, nearly three‐quarters of utilities (76% of the population served) showed a moderate risk of fire and some need for improved fire preparedness. Information developed here could provide a useful framework from which utility managers can better assess their likely wildfire risk and preparation plans.
A randomized trial of the effects of COMT inhibition on subjective response to alcohol: Moderation by baseline COMT activity and mediation of alcohol self‐administration
Authors: Schacht Joseph P. , Kubicki Matthew , Anton Raymond F. 
Published: November 2023

AbstractBackgroundPoor inhibitory control and enhanced subjective response to alcohol are interrelated risk factors for alcohol use disorder (AUD) that share underlying neural substrates, including dopamine signaling in the right prefrontal cortex, a potential target for pharmacological intervention. Cortical dopamine inactivation is primarily regulated by catechol‐O‐methyltransferase (COMT), an enzyme with large variation in activity as a function of the COMT rs4680 (val158met) single nucleotide polymorphism. In a previous randomized, placebo‐controlled trial of the COMT inhibitor tolcapone (200 mg TID) in non‐treatment‐seeking participants with AUD, we found that tolcapone, relative to placebo, reduced alcohol self‐administration only among rs4680 val‐allele homozygotes, whose COMT activity is higher than in met‐allele carriers.MethodsWe conducted secondary analyses of the effects of tolcapone and baseline COMT activity, as indexed by both rs4680 genotype and an enzymatic activity assay, on the subjective response to alcohol in a bar‐laboratory paradigm among 60 participants in the previous trial.ResultsTolcapone did not affect alcohol‐induced stimulation or sedation more than placebo. However, baseline COMT activity moderated the effects of the drug on both outcomes, such that tolcapone‐treated participants with higher baseline COMT activity had less stimulation (p = 0.008) and sedation (p = 0.053) than participants with lower baseline COMT activity and those treated with placebo. Additionally, alcohol‐induced stimulation significantly mediated the interacting effects of baseline COMT activity and tolcapone on bar‐laboratory self‐administration.ConclusionsTolcapone may reduce subjective response to alcohol more effectively among individuals with preexisting high COMT activity an effect that could account for the drug's reduction of alcohol consumption among these individuals.
The endodontic‐periodontal juncture: Where two worlds meet. An overview of endo‐perio lesions
Authors: Evans M 
Published: November 2023

ABSTRACTEndodontic and periodontal infections can be difficult to differentiate from one another and often share common clinical features making diagnosis challenging. The aim of this review is to discuss endodontic and periodontal infections in situations where they occur concurrently, or where one influences the other. The available literature investigating endodontic and periodontal infections was examined for contemporary knowledge regarding endodontic‐periodontal interactions. Strategies to facilitate diagnosis and treatment planning are discussed. When endodontic and periodontal infections occur together, or signs and symptoms are similar, diagnosis can be challenging. Determining the primary source of infection is imperative to ensure appropriate treatment planning. The pulp and periodontal tissues are intimately related, with many possible pathways for infection from one to the other. Diagnosis of the primary source of the infection can be difficult and sometimes an inter‐disciplinary approach to treatment is required. © 2023 Australian Dental Association.
Prevalence, contemporary trends and associated factors of potentially inappropriate prescription of edoxaban in real‐world clinical practice: A subanalysis of the SUNSHINE registry
Authors: Zhao Shujuan , Dai Hengfen , Chen Jiaxin , Ni Ming , Peng Wenxing , Li Xiaoyu , Li Fen , Chen Boya , Cai Haixia , Liu Yinping , Gu Zhichun , Du Song , Ma Peizhi 
Published: November 2023

AbstractAimAs the direct oral anticoagulant most recently approved in China, data pertaining to clinical edoxaban use are still scarce. This study investigated the prevalence of and contemporary trends in edoxaban prescription among Chinese patients as well as factors associated with its inappropriate use in a multicentre registry of patients treated in real‐world clinical practice.MethodsThis real‐world, prospective, multicentre and non‐interventional study included 1005 inpatients treated with edoxaban. According to National Medical Products Administration and European Heart Rhythm Association guidelines, edoxaban therapy was determined to be appropriate or inappropriate in each case.ResultsThe median patient age was 70.0 years (interquartile range 61.0‐78.0 years) and 46.3% were women. Overall, 456 (45.4%) patients received inappropriate edoxaban therapy, and common issues included an inappropriately low dosage (183, 18.2%) or wrong drug selection (109, 10.8%), high dosage (73, 7.3%), unreasonable off‐label use (49, 4.9%), contraindicated medication combinations (27, 2.7%) and incorrect administration timing (16, 1.6%). Several factors, such as age ≥75 years (odds ratio [OR] = 1.921, 95% confidence interval [CI] 1.355‐2.723, P < 0.001), weight >60 kg (OR = 2.657, 95%CI 1.970‐3.583, P < 0.001), severe renal insufficiency (OR = 1.988, 95% CI 1.043‐3.790, P = 0.037), current anaemia (OR = 1.556, 95% CI 1.151‐2.102, P = 0.004) and history of bleeding (OR = 2.931, 95% CI 1.605‐5.351, P < 0.001) were associated with an increased risk of inappropriate edoxaban therapy, whereas factors associated with cardiovascular specialties, such as admission to a cardiovascular department (OR = 0.637, 95% CI 0.464‐0.873, P = 0.005), dronedarone use (OR = 0.065, 95% CI 0.026‐0.165, P < 0.001) and amiodarone use (OR = 0.365, 95% CI 0.209‐0.637, P < 0.001) decreased this risk.ConclusionIn this real‐world study, 45.4% of patients received an inappropriate treatment with edoxaban. Multiple clinical characteristics can help identify patients who should receive edoxaban. Further development and implantation of educational activities and management strategies are needed to ensure the correct use of edoxaban.
Clinical decision‐making in benzodiazepine deprescribing by healthcare providers vs. AI‐assisted approach
Authors: Bužančić Iva , Belec Dora , Držaić Margita , Kummer Ingrid , Brkić Jovana , Fialová Daniela , Ortner Hadžiabdić Maja 
Published: November 2023

AbstractAimsThe aim of this study was to compare the clinical decision‐making for benzodiazepine deprescribing between a healthcare provider (HCP) and an artificial intelligence (AI) chatbot GPT4 (ChatGPT‐4).MethodsWe analysed real‐world data from a Croatian cohort of community‐dwelling benzodiazepine patients (n = 154) within the EuroAgeism H2020 ESR 7 project. HCPs evaluated the data using pre‐established deprescribing criteria to assess benzodiazepine discontinuation potential. The research team devised and tested AI prompts to ensure consistency with HCP judgements. An independent researcher employed ChatGPT‐4 with predetermined prompts to simulate clinical decisions for each patient case. Data derived from human‐HCP and ChatGPT‐4 decisions were compared for agreement rates and Cohen's kappa.ResultsBoth HPC and ChatGPT identified patients for benzodiazepine deprescribing (96.1% and 89.6%, respectively), showing an agreement rate of 95% (κ = .200, P = .012). Agreement on four deprescribing criteria ranged from 74.7% to 91.3% (lack of indication κ = .352, P < .001; prolonged use κ = .088, P = .280; safety concerns κ = .123, P = .006; incorrect dosage κ = .264, P = .001). Important limitations of GPT‐4 responses were identified, including 22.1% ambiguous outputs, generic answers and inaccuracies, posing inappropriate decision‐making risks.ConclusionsWhile AI‐HCP agreement is substantial, sole AI reliance poses a risk for unsuitable clinical decision‐making. This study's findings reveal both strengths and areas for enhancement of ChatGPT‐4 in the deprescribing recommendations within a real‐world sample. Our study underscores the need for additional research on chatbot functionality in patient therapy decision‐making, further fostering the advancement of AI for optimal performance.
Anti‐HTLV‐1 immunity combined with proviral load as predictive biomarkers for adult T‐cell leukemia‐lymphoma
Authors: Yamada Asami , Yasunaga Jun‐ichirou , Liang Lihan , Zhang Wenyi , Sunagawa Junya , Nakaoka Shinji , Iwami Shingo , Kogure Yasunori , Ito Yuta , Kataoka Keisuke , Nakagawa Masanori , Iwanaga Masako , Utsunomiya Atae , Koh Ki‐Ryang , Watanabe Toshiki , Nosaka Kisato , Matsuoka Masao 
Published: November 2023

AbstractHuman T‐cell leukemia virus type 1 (HTLV‐1) establishes chronic infection in humans and induces a T‐cell malignancy called adult T‐cell leukemia‐lymphoma (ATL) and several inflammatory diseases such as HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Persistent HTLV‐1 infection is established under the pressure of host immunity, and therefore the immune response against HTLV‐1 is thought to reflect the status of the disease it causes. Indeed, it is known that cellular immunity against viral antigens is suppressed in ATL patients compared to HAM/TSP patients. In this study, we show that profiling the humoral immunity to several HTLV‐1 antigens, such as Gag, Env, and Tax, and measuring proviral load are useful tools for classifying disease status and predicting disease development. Using targeted sequencing, we found that several carriers whom this profiling method predicted to be at high risk for developing ATL indeed harbored driver mutations of ATL. The clonality of HTLV‐1‐infected cells in those carriers was still polyclonal; it is consistent with an early stage of leukemogenesis. Furthermore, this study revealed significance of anti‐Gag proteins to predict high risk group in HTLV‐1 carriers. Consistent with this finding, anti‐Gag cytotoxic T lymphocytes (CTLs) were increased in patients who received hematopoietic stem cell transplantation and achieved remission state, indicating the significance of anti‐Gag CTLs for disease control. Our findings suggest that our strategy that combines anti‐HTLV‐1 antibodies and proviral load may be useful for prediction of the development of HTLV‐1‐associated diseases.
Serial comprehensive genomic profiling by next‐generation sequencing for patients with metastatic colorectal cancer
Authors: Olsen Steven , Nakamura Yoshiaki 
Published: November 2023

In a real‐world database of metastatic colorectal cancer (mCRC) in the United States, comprehensive genomic profiling (CGP) using plasma‐based next‐generation sequencing identified potentially actionable profiles for approximately one‐third of the patients with both the first test and again with a second test after disease progression, with around 60% of all patients tested receiving therapy consistent with the CGP results at each line of treatment. This suggests a role for CGP prior to more than one line of mCRC treatment.