bluuebunny/crossref_metadata_2025_split huggingface dataset:
The viscosity‐enhancing effect of carob bean gum and sodium carboxymethylcellulose when added to infant formula
Authors: Baert Kyara , Ombecq Mathieu , Van Winckel Myriam , Henry Silke , Tommelein Eline , Vanhoorne Valérie 
Published: January 2024

AbstractDespite limited supporting evidence, the practice of thickening breast milk or infant formula with commercially available thickening agents is prevalent. This study explored the viscosity‐enhancing impact of carob bean gum (CBG) and sodium carboxymethylcellulose (NaCMC) when added to infant formula at various concentrations and for different thickening durations. The findings indicate that thickening leads to an exponential increase in milk viscosity, from 25% of the recommended dosage onward. This suggests that minor adjustments in dosage can significantly impact formula thickness, underscoring the importance of accurately dosing and preparing infant milk. The considerable variability in viscosity also emphasizes the need for thoughtful selection of teat size, considering the energy expenditure of the sucking infant. When using 50% of the recommended CBG dose or 25% of NaCMC, the resulting viscosity matches that of a commercially available casein‐based formula containing CBG for anti‐regurgitation. In the case of CBG, a viscosity plateau is only reached after 30 min. Therefore, educating parents on the correct handling and preparation steps for CBG‐thickened infant milk is crucial, including a 30‐min waiting period to achieve the intended thickening effect.
High‐resolution dataset of nocturnal air temperatures in Bern, Switzerland (2007–2022)
Authors: Burger Moritz , Gubler Moritz , Brönnimann Stefan 
Published: January 2024

AbstractTo prepare for a hotter future, information on intra‐urban temperature distributions is crucial for cities worldwide. In recent years, different methods to compute high‐resolution temperature datasets have been developed. Such datasets commonly originate from downscaling techniques, which are applied to enhance the spatial resolution of existing data. In this study, we present an approach based on a fine‐scaled low‐cost urban temperature measurement network and a formerly developed land use regression approach. The dataset covers mean nocturnal temperatures of 16 summers (2007–2022) of a medium‐sized urban area with adapted land cover data for each year. It has a high spatial (50 m) and temporal (daily) resolution and performs well in validation (RMSEs of 0.70 and 0.69 K and mean biases of +0.41 and −0.19 K for two validation years). The dataset can be used to examine very detailed statistics in space and time, such as first heatwave per year, cumulative heat risks or inter‐annual variability. Here, we evaluate the dataset with two application cases regarding urban planning and heat risk assessment, which are of high interest for both researchers and practitioners. Due to potential biases of the low‐cost measurement devices during daytime, the dataset is currently limited to night‐time temperatures. With minor adaptions, the presented approach is transferable to cities worldwide in order to set a basis for researchers, city administrations and private stakeholders to address their heat mitigation and adaptation strategies.
Acute and definitive management of oropharyngeal hemorrhage in patients with squamous cell carcinoma of the oropharynx
Authors: Araujo Ana V. , Wax Mark K. , Clayburgh Daniel R. , Andersen Peter E. , Chandra Ravi A. , Li Ryan J. 
Published: January 2024

AbstractBackgroundMassive oropharyngeal bleeding post‐chemoradiotherapy is a life‐threatening condition that requires emergent management.MethodsThis retrospective case series included 11 patients with oropharyngeal squamous cell carcinoma who suffered from massive bleeding during or following treatment with definitive chemoradiotherapy. Details of acute and definitive management of oropharyngeal bleeding are reported.ResultsNine of 11 hemorrhagic events occurred a mean (SD) of 88.6 days (53.6) after radiotherapy. Airway intubation and embolization were performed in 10 of 11 patients, followed by surgery in 7 of 11 patients. The most commonly embolized vessels were the external carotid and lingual arteries. At the time of discharge, 3 of 11 patients had a tracheostomy, and 7 of 11 continued to use a gastrostomy tube. Four patients died.ConclusionsHemorrhagic complications in oropharyngeal cancer treatment require emergent responses. Developing a workflow for coordination between multidisciplinary teams can maximize probability of survival and decrease morbidity.
ZNF384 fusion transcript levels for measurable residual disease monitoring in adult B‐cell acute lymphoblastic leukemia
Authors: Shi Zong‐Yan , Wang Xu , Chen Wen‐Min , Li Ling‐Di , Hao Yue , Li Jin‐Ying , Sun Kai , Zhao Xiao‐Su , Jiang Hao , Jiang Qian , Huang Xiao‐Jun , Qin Ya‐Zhen 
Published: January 2024

AbstractZinc finger protein 384 (ZNF384) rearrangement defined a novel subtype of B‐cell acute lymphoblastic leukemia (B‐ALL). The prognostic significance of ZNF384 fusion transcript levels represented measurable residual disease remains to be explored. ZNF384 fusions were screened out in 57 adult B‐ALL patients at diagnosis by real‐time quantitative polymerase chain reaction and their transcript levels were serially monitored during treatment. The reduction of ZNF384 fusion transcript levels at the time of achieving complete remission had no significant impact on survival, whereas its ≥2.5‐log reduction were significantly associated with higher relapse free survival (RFS) and overall survival (OS) rates after course 1 consolidation (p = 0.022 and = 0.0083) and course 2 consolidation (p = 0.0025 and = 0.0008). Compared with chemotherapy alone, allogeneic hematopoietic stem cell transplantation (allo‐HSCT) significantly improved RFS and OS of patients with <2.5‐log reduction after course 1 consolidation (p < 0.0001 and = 0.0002) and course 2 consolidation (p = 0.0003 and = 0.019), whereas exerted no significant effects in patients with ≥2.5‐log reduction (all p > 0.05). ZNF384 fusion transcript levels after course 1 and course 2 consolidation strongly predict relapse and survival and may guide whether receiving allo‐HSCT in adult B‐ALL.
Association between glucocorticoid receptor beta and steroid resistance: A systematic review
Authors: Hasan Md. Mojahidur , Tory Sehreen 
Published: January 2024

AbstractBackgroundGlucocorticoids are the most commonly used anti‐inflammatory drugs for a variety of diseases, despite the fact that resistance to them is growing in a number of conditions. There is currently no biomarker that can be used to identify steroid resistance. According to a number of studies, an overexpression of the glucocorticoid receptor beta (GR‐β) isoform is associated with steroid‐resistant illness. Our goal is to find out whether or not steroid‐resistant disorders are associated with an increased level of GR‐β expression.MethodsWe conducted searches in the databases of Web of Science and PubMed until January 17, 2023. This systematic review was done according to the preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The Joanna Briggs Institute Appraisal scale was used to assess the quality of the included studies.ResultsAfter the initial search, we identified 556 papers and finally included 20 studies. Twelve of these studies found an elevated level of GR‐β in the steroid resistant group. All five studies on asthma, two out of three on nasal polyps, both studies on ulcerative colitis found an up regulation of GR‐β in steroid resistant group as compared to steroid‐sensitive groups. GR‐β was also shown to be elevated in patients with allergic rhinitis, Crohn's disease and rheumatoid arthritis. In the majority of the investigations, higher levels of GR‐β were identified in peripheral blood mononuclear cells through the use of reverse transcription polymerase chain reaction.ConclusionGR‐β was associated with steroid‐resistant diseases. It was overexpressed in steroid‐resistant diseases and has the potential to be used as a biomarker for disorders involving steroid resistance.
Ocular toxicity associated with anti‐HER2 agents in breast cancer: A pharmacovigilance analysis using the FAERS database
Authors: Chen Heng , Yang Guoping , Ma Junlong 
Published: January 2024

AbstractAnti‐human epidermal growth factor receptor 2 (HER2) agents have exhibited pronounced tumor‐inhibitory activity, yet the accompanying ocular toxicity has frequently been underestimated. We aim to conduct a comprehensive comparative analysis of ocular toxicity risk related to various anti‐HER2 agents. We executed a retrospective pharmacovigilance investigation based on the FDA Adverse Event Reporting System (FAERS) database, covering the period from Q2 2018 to Q1 2023. The disproportionality analysis was performed to assess ocular toxicity risk. Multivariate logistic regression was implemented to mitigate potential biases. Moreover, the time to onset of ocular toxicity was also evaluated. A total of 3467 ocular adverse event (AE) reports concerning anti‐HER2 agents were collected. At the preferred term (PT) level, there were 69 positive signals, among which excessive eye blinking, abnormal sensation in the eye, and asthenopia presented a significant risk. In comparison to tyrosine kinase inhibitors (TKIs), antibody drugs were associated with a broader range of ocular disorders at Standardized MedDRA Queries (SMQ)levels, including conjunctival disorders, corneal disorders, ocular infections, ocular motility disorders, optic nerve disorders, and retinal disorders. In terms of onset time, pertuzumab displayed an earlier onset at 21.5 days, while trastuzumab deruxtecan had the latest at 91.5 days. In summary, our study reveals varying degrees of ocular toxicity related to anti‐HER2 agents, with a significantly higher risk observed in antibody drugs. Additionally, novel ocular toxicity signals, not documented in product labels, have been detected. In the future, further research will be necessary to validate our findings.
Quantitative imaging of dynamic myocardial blood flow using dual‐head rapidly rotating gantry single‐photon emission computed tomography to enhance coronary artery disease diagnosis
Authors: Bai Yongli , Bai Bingyue , Miao Gang , Wang Wenzhi , Wang Longmei , Ma Dan , Shi Wenjing 
Published: January 2024

AbstractBackgroundThis study aimed to evaluate the performance of myocardial blood flow (MBF) and myocardial flow reserve (MFR) for diagnosing coronary artery disease (CAD) using dynamic single‐photon emission computed tomography/computed tomography (SPECT/CT) with a dual‐head rapidly rotating gantry (RRG) and to compare this method with conventional myocardial perfusion imaging (MPI), which can be obtained in a one‐stop manner.MethodsA total of 93 patients with suspected or confirmed CAD who underwent RRG SPECT/CT were retrospectively enrolled. They underwent invasive coronary angiography (ICA) and conventional MPI within 3 weeks. Based on the ICA results, the performance of MBF quantitative and semi‐quantitative parameters were compared at patient and vessel levels using ≥50% and ≥75% stenosis as the criteria for CAD diagnosis. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of two types of parameters.ResultsFor patient‐level analysis, the area under ROC curves (AUCs) for stress MBF (sMBF), MFR, summed stress score (SSS), and summed different score (SDS) were 0.971, 0.939, 0.612, and 0.546, respectively, for ≥50% stenosis as positive, and were 0.983, 0.932, 0.735, and 0.509, respectively, for ≥75% stenosis as positive criteria. For vessel‐level analysis, the AUCs of sMBF, MFR, SSS, and SDS were 0.981, 0.933, 0.636, and 0.560, respectively, for ≥50% stenosis as positive and were 0.984, 0.933, 0.767, and 0.583, respectively, for ≥75% stenosis as positive criteria.ConclusionsCompared with semi‐quantitative parameters of conventional MPI, MBF quantitative parameters of dual‐head RRG SPECT had higher diagnostic performance for CAD.
Preliminary investigation of objective and subjective experiences of relatives of individuals with hoarding behaviors
Authors: Mayes Tina L. , Dozier Mary E. , Davidson Eliza J. , Rosenfarb Irwin F. , Bratiotis Christiana , Ayers Catherine R. 
Published: January 2024

AbstractObjectiveFamilies of individuals with hoarding symptoms report substantial burden; however, there has been no investigation of potential positive experiences. The objective of this study was to examine the experiences reported by individuals with a relative with elevated hoarding symptoms using a cross‐sectional design. The current investigation expands on the literature in this area by incorporating a detailed interview of experiences in conjunction with validated measures of hoarding symptomology.MethodsTwenty‐nine adults with relatives with elevated hoarding symptoms completed self‐report measures of hoarding severity for themselves and their relative and a clinician‐administered assessment of their experiences with their family member with hoarding symptoms.ResultsParticipants endorsed significant burden across a range of areas, including permanent changes in their daily routine. The majority (93%) of participants reported at least one positive experience, with 69% endorsing companionship as a benefit of the relationship. Greater symptom severity of the relative with hoarding symptoms was associated with greater subjective burden and decreased positive experiences.ConclusionOur results add further evidence to the potential for interpersonal psychotherapy to lead to a reduction in hoarding symptomology.
GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3‐L1 cells
Authors: Kim Soon‐Young , Park Seung‐Yoon , Kim Jung‐Eun 
Published: January 2024

AbstractObesity and metabolic disorders caused by alterations in lipid metabolism are major health issues in developed, affluent societies. Adipose tissue is the only organ that stores lipids and prevents lipotoxicity in other organs. Mature adipocytes can affect themselves and distant metabolism‐related tissues by producing various adipokines, including adiponectin and leptin. The engulfment adaptor phosphotyrosine‐binding domain‐containing 1 (GULP1) regulates intracellular trafficking of glycosphingolipids and cholesterol, suggesting its close association with lipid metabolism. However, the role of GULP1 in adipocytes remains unknown. Therefore, this study aimed to investigate the function of GULP1 in adipogenesis, glucose uptake, and the insulin signaling pathway in adipocytes. A 3T3‐L1 cell line with Gulp1 knockdown (shGulp1) and a 3T3‐L1 control group (U6) were established. Changes in shGulp1 cells due to GULP1 deficiency were examined and compared to those in U6 cells using microarray analysis. Glucose uptake was monitored via insulin stimulation in shGulp1 and U6 cells using a 2‐NBDG glucose uptake assay, and the insulin signaling pathway was investigated by western blot analysis. Adipogenesis was significantly delayed, lipid metabolism was altered, and several adipogenesis‐related genes were downregulated in shGulp1 cells compared to those in U6 cells. Microarray analysis revealed significant inhibition of peroxisome proliferator‐activated receptor signaling in shGulp1 cells compared with U6 cells. The production and secretion of adiponectin as well as the expression of adiponectin receptor were decreased in shGulp1 cells. In particular, compared with U6 cells, glucose uptake via insulin stimulation was significantly decreased in shGulp1 cells through the disturbance of ERK1/2 phosphorylation. This is the first study to identify the role of GULP1 in adipogenesis and insulin‐stimulated glucose uptake by adipocytes, thereby providing new insights into the differentiation and functions of adipocytes and the metabolism of lipids and glucose, which can help better understand metabolic diseases.
Evaluation of the type of fetal umblical‐portal anastomosis in late‐onset fetal growth restriction: A case–control study
Authors: Kaymak Didem , Madazli Riza 
Published: January 2024

AbstractPurposeTo evaluate the type of umbilical‐portal anastomosis in late‐onset fetal growth restriction (LO‐FGR) and appropriate for gestational age (AGA) fetuses. To investigate the impact of the type of umbilical‐portal anastomosis on the adverse outcomes in LO‐FGR.MethodThis study observed 150 pregnancies with AGA fetuses and 62 pregnancies with fetuses with LO‐FGR. In each case, the point of reference for measuring the abdominal circumference was established. The type of umbilical‐portal anastomosis was evaluated as T‐shaped, X‐shaped, and H‐shaped according to the shape of main portal vein and portal sinus. Incidences of the type of umbilical‐portal anastomosis in AGA and LO‐FGR fetuses were evaluated.ResultsT‐shaped anastomosis was the most common (56.7%) in the AGA group and X‐shaped (66.1%) in the LO‐FGR group. In LO‐FGR, T‐shape anastomosis was significantly lower and X‐shape anastomosis was significantly higher than AGA (p < 0.001). X‐shaped anastomosis was associated with LO‐FGR and the RR was 2.3 (95% CI 1.5–3.6; p < 0.001). Incidences of admission to NICU and emergency C/S for fetal distress were higher in fetuses with X ‐shaped anastomosis in the LO‐FGR (p < 0.05).ConclusionX‐shaped umbilical‐portal anastomosis have a prognostic significance in LO‐FGR fetuses.
Are MOOCs a new way of learning in engineering education in light of the literature? A systematic review and bibliometric analysis
Authors: Turan Zeynep , Yilmaz Rabia Meryem 
Published: January 2024

AbstractBackgroundMassive open online courses (MOOCs) have gained popularity as a form of distance education, highlighting the need for additional research. Various studies have systematically examined scholarly research on MOOCs. However, the reviewed academic publications on the use of MOOCs in engineering education are limited.Purpose/Hypothesis(es)This study aims to examine the implementation of MOOCs in engineering education using systematic review and bibliometric analysis methods.Design/MethodThis study examines 68 studies from the Web of Science database that fall within the scope of the systematic review and 257 studies for bibliometric analysis.ResultsSince 2018, there has been a growing number of studies exploring the uses of MOOCs in engineering education. The quantitative research method is the most preferred, while the mixed method is the least preferred. The study found that using MOOCs in engineering education resulted in positive student perceptions and satisfaction. However, the lack of interactivity between learners and instructors or among learners was the most frequently reported problem. Moreover, the bibliometric analysis indicates that reviewed studies extensively explore learners' engagement, interactions, and feedback processes. Recently, academic research focused on sentiment analysis, deep learning, educational technology, machine learning, and text mining.ConclusionsThere is a need for further investigation into utilizing MOOCs in engineering education. This study's evaluation of MOOCs' pros and cons yields essential insights for optimizing their use in engineering education. By leveraging the positive aspects outlined in the study, educators can enhance engineering students' satisfaction and participation in MOOCs. These findings offer a valuable resource for researchers exploring MOOC‐related topics in engineering education.
Endoscopic ultrasound‐guided biopsy using a three‐prong asymmetry tip needle for pancreatic tumors and peridigestive tract lesions: Retrospective single‐center study
Authors: Shionoya Kento , Tonozuka Ryosuke , Mukai Shuntaro , Tsuchiya Takayoshi , Tanaka Reina , Yamamoto Kenjiro , Nagai Kazumasa , Mastunami Yukitoshi , Kojima Hiroyuki , Itoi Takao 
Published: January 2024

AbstractBackgroundEndoscopic ultrasound‐guided tissue acquisition is vital for diagnosing pancreatic and peridigestive tract lesions. A new three‐prong asymmetry tip needle has been developed for this procedure. In this study, we retrospectively assessed the diagnostic ability, tissue collection volume, and procedural adverse events of the three‐prong asymmetry tip needle for solid pancreatic, subepithelial, and other organ lesions.MethodsWe analyzed the data of 58 consecutive patients who underwent endoscopic ultrasound‐guided tissue acquisition using a three‐prong asymmetry tip needle between August 2022 and April 2023 at a single care center.ResultsThe tissue collection rate was 91.4% with 89.7% accuracy, 89.3% sensitivity, 100% specificity, 100% positive predictive value, and 25% negative predictive value. No significant differences in collection rates or diagnostic performance were observed based on the target organ, puncture route, or lesion size. Using our original assessment method, the average histological core tissue score was 3.1 ± 0.8, whereas the blood contamination volume was 2.5 ± 0.8. Only one of 58 patients (1.7%) developed a pancreatic fistula of moderate severity as an adverse event.ConclusionsThe three‐prong asymmetry tip needle demonstrated good diagnostic capability and adequate sample volume with safety for pancreatic, subepithelial, and other organ lesions.
Altered neurovascular coupling in migraine without aura
Authors: Zhou Qichen , Zhang Chao , Du Jiaxin , Xin Ziyue , Qi Yapeng , Wang Yihan , Li Shen‐Jie , Wang Weikan , Zhou Chenglin , Liu Jian‐Ren , Du Xiaoxia 
Published: January 2024

AbstractNeurovascular coupling (NVC) provides new insights into migraine, a neurological disorder impacting over one billion people worldwide. This study compared NVC and cerebral blood flow (CBF) in patients with migraine without aura (MwoA) and healthy controls. About 55 MwoA patients in the interictal phase and 40 age‐ and sex‐matched healthy controls underwent resting‐state functional magnetic resonance imaging and arterial spin‐labeling perfusion imaging scans. The CBF and resting‐state neuronal activity indicators, including the amplitudes of low‐frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC), were calculated for each participant. The global and regional NVCs were assessed using cross‐voxel CBF‐neuronal activity correlations and CBF/neuronal activity ratios. Patients with MwoA showed increased CBF/ALFF ratios in the left media, superior and inferior frontal gyri, and anterior cingulate gyrus, increased CBF/DC ratios in the left middle and inferior frontal gyri, and increased CBF/ReHo ratios in the right corpus callosum and right posterior cingulate gyrus. Lower CBF/ALFF ratios in the right rectal gyrus, the left orbital gyrus, the right inferior frontal gyrus, and the right superior temporal gyrus were also found in the MwoA patients. Furthermore, the CBF/ALFF ratios in the inferior frontal and superior temporal gyri were positively correlated with the Headache Impact Test scores and Hamilton anxiety scale scores in the MwoA patients. These findings provide evidence for the theory that abnormal NVC contributes to MwoA.