bluuebunny/crossref_metadata_2025_split huggingface dataset:
Land conservation and the renewable energy transition are simultaneously possible in Brazil
Authors: Borba Paula Conde Santos , Júnior Wilson Cabral de Sousa , Pfenninger Stefan 
Published: February 2024

Abstract
Brazil is crucial to tackling climate change and halting biodiversity loss. Yet given its intention to rely on biofuels for clean energy, there is a growing risk that uncoordinated policy leads these goals to compete with each other. Here we explore their interplay through long-term energy scenarios based on a spatially explicit energy system model. We find that in a baseline scenario where Brazil doubles biofuel use by 2050, substantial dedicated land is needed, converting mostly degraded pastures. More importantly, with appropriate planning, renewable energy combined with biofuels can meet demand in highly electrified systems where emissions decline by 40%-91% without conflicting with conservation-relevant lands and without a noticeable effect on energy system costs. Finally, these conservation-relevant lands can be reforested and thereby contribute up to 15.43 Gton of carbon stored, showing that climate change mitigation and ecosystem recovery can be synergistic.
Enhanced Meridional Transport in the Antarctic Circumpolar Current under Global Warming
Authors: Xu Yongsheng , Zhao Dandan 
Published: February 2024

Abstract
The prevailing view posits that the meridional transport of the Antarctic Circumpolar Current (ACC) is predominantly driven by wind stress curl instigated by the Southern Hemisphere's westerly winds. However, this perspective, often rooted in model simulations under preindustrial conditions, might not be entirely applicable to the contemporary era, characterized by rapid greenhouse gas emissions. Analysis of observational and Reanalyzed datasets during 1993–2020 reveals a paradox: while the strength of the Southern Hemisphere westerly winds has intensified, the corresponding wind stress curl has diminished. Instead, a significant fraction of the energy transferred to the ocean by the wind is absorbed by eddies, increasing eddy potential vorticity anomalies. The escalation in positive potential vorticity anomalies, transported by mesoscale eddies, triggers an acceleration in the meridional transport. This phenomenon counteracts and even overshadows the effects of diminishing wind stress curl, potentially exerting a substantial influence on global climate dynamics. Our findings illuminate the intricate dynamics governing the ACC and underscore its critical role in ice melt and climate regulation.
LCDDF: An Adaptive and Learning based Framework with Feature Selection for Efficient Detection of Concept Drift in Data Streams
Authors: Trupthi M , CH NARASIMHA CHARY , SNEHA SOWJANYA , Prasad M. Hari , K Ms Swathi 
Published: February 2024

Abstract
In the contemporary era, there has been increased collaboration among machines and things due to innovative technologies like Internet of Things (IoT). With use cases of IoT pertaining to industries, there is unprecedented increase in data generation and dissemination resulting in large data streams. In this context, data stream analytics is given paramount importance but it suffers from concept drift issues leading to performance deterioration in many automation applications. There are many existing methods for automatic detection of concept drifts in data streams. However, there is need for an adaptive approach that learns dynamically through machine learning (ML) techniques. Another drawback of existing method is lack of efficient feature selection method that leverages drift detection performance. In this paper, we address these shortcomings by proposing a framework known as Learning based Concept Drift Detection Framework (LCDDF). We also proposed two algorithms, namely Concept Drift-aware Feature Engineering (CDFE) and Learning based Model Selection (LbMS), to realize the framework and improve the state of the art in detection accuracy. The former is used to perform feature engineering which concept drift-aware leading to improving quality of learning process. The latter detects best models for making an ensemble towards improving prediction performance. Our empirical study has revealed that the proposed framework with underlying algorithms outperform many state of the art methods.
Hybrid Beamforming for Massive MIMO Antenna Array Processor in 5G Wireless Communication
Authors: Razi SM Muhtashin Al , Hasan Tanvir , Hossain Md. Selim 
Published: February 2024

Abstract

In order to overcome limitations in available frequency ranges, regulatory agencies such as the FCC are actively searching for ways to maximize the efficiency of bandwidth usage and improve customer satisfaction within the field of radio communication. This study highlights the crucial significance of Massive Multiple Input Multiple Output (MIMO) systems in addressing these problems in 5G wireless networks, resulting in improved spectrum efficiency and stability. The study presents a geometric channel model for massive MIMO systems that make use of Uniform Linear Array (ULA), Uniform Rectangular Array (URA), and Uniform Circular Array (UCA). Following that, a hybrid beamforming system is introduced, which integrates enhanced algorithms in both digital and analog precoders. This innovative methodology significantly minimizes approximation errors, thus improving spectral efficiency (SE). A comparative analysis is performed by implementing the hybrid beamforming algorithm on different array topologies to evaluate the differences between fully digital and hybrid systems. Although there is a slight decrease in SE, the hybrid model offers a notable benefit by requiring fewer antenna components upto 98.43%, making it an attractive choice in terms of performance and cost. Moreover, the study emphasizes the exceptional efficacy of the hybrid approach in the URA system, particularly when combined with specific array configurations and found 38.72 bits/s/Hz SE.
Quorum Sensing Model for Nutrient-dependent Evolution of Cultured Bacteria: Theoretical Framework and in Silico Study
Authors: Maslovskaya Anna , Kuttler Christina , Shevkun Ivan , Chebotarev Alexander , Kovtanyuk Andrey 
Published: February 2024

Abstract

The evolutionary dynamics of cell-to-cell communication in bacterial populations can be examined using mathematical modeling and computer simulations. In the present study, the model of bacterial quorum sensing in colonies cultivated on nutrient media is explored from theoretical and computational points of view. The proposed approach is based on combining the deterministic model for bacterial nutrient-dependent biomass growth and the reaction-diffusion model describing spatial-temporal characteristics of bacterial quorum sensing. The unique solvability of the initial-boundary value problem for the mathematical model of bacterial quorum sensing is proved. The theoretical results are based on the derivation of new \textit{a priori} estimates for the solution of the system of semilinear parabolic equations. The nonlinear differential problem is solved numerically and the software implementation is executed in combination with the procedure of fractal dimension measure for bacterial pattern boundaries. A series of computational experiments are conducted to analyze the behavior of key chemical substances characterizing the quorum sensing attributed to \textit{Pseudomonas} genus bacteria during the evolution of dendrites as well as floral patterns in nutrient media.
Mathematics Subject Classification (2020) 92-10 · 92D25 · 37M05
Evaluating the Associations Between Compliance with CKD Guideline Component Metrics and Renal Outcomes
Authors: Nyma Zannatun , Kitaoka Kaori , Yano Yuichiro , Kanegae Hiroshi , Bayaraa Nomin , Kishi Seiji , Nagasu Hajime , Nakano Toshiaki , Wada Jun , Maruyama Shoichi , Nakagawa Naoki , Tamura Kouichi , Yokoo Takashi , Yanagita Motoko , Narita Ichiei , Yamagata Kunihiro , Wada Takashi , Tsuruya Kazuhiko , Nakashima Naoki , Isaka Yoshitaka , Nangaku Masaomi , Kashihara Naoki , Okada Hirokazu 
Published: February 2024

Abstract
Background
Understanding the association between compliance to the Chronic Kidney Disease (CKD) guidelines in real-world clinical settings and renal outcomes remains a critical gap in knowledge.
Methods
A comprehensive analysis was conducted using data from a national, multicenter CKD registry. This study included 4,455 patients with an estimated glomerular filtration rate (eGFR) measurement on the index date and eight additional metrics recorded within six months. These metrics comprised serum electrolyte levels, low-density lipoprotein cholesterol, hemoglobin, and the use of renin-angiotensin system inhibitors. The primary outcome was a composite of renal events, defined by a decline in eGFR to < 15 mL/min/1.73 m² or a reduction of ≥ 30% in eGFR, confirmed by follow-up tests.
Results
Over a median follow-up of 513 days, 838 renal events were observed. High serum potassium levels (> 5.4 mmol/L) were associated with increased event rates compared to lower levels. Similarly, low serum sodium-chloride levels (< 33) correlated with higher event rates. Usage of renin-angiotensin system inhibitors, low serum calcium (< 8.4 mg/dL), and high uric acid levels (> 7.0 mg/dL) were also linked to increased events. Conversely, higher hemoglobin levels (≥ 13g/dL) were associated with lower event rates. Adherence to guidelines, categorized into quartiles based on the number of met metrics, revealed a significantly reduced risk of events in the highest compliance group (meeting 8 metrics) compared to the lowest (0–5 metrics).
Conclusions
Compliance to CKD guidelines in clinical practice is significantly associated with improved renal outcomes, emphasizing the need for guideline-concordant care in the management of CKD.
Serological survey of vector-borne pathogens in shelter dogs from the Metropolitan Area of Bucaramanga, Colombia
Authors: Pinilla Juan Carlos , Rincón Diego Fernando , Florez Angel , Pinilla Andrea Isabel 
Published: February 2024

Abstract
Canine vector-borne pathogens are found in many regions and represent a challenge for animal health. Shelter dogs are found to be an important health and ecological factor in urban areas in Colombia. Therefore, the aim of the present research was to determine the seroprevalence of canine vector-borne pathogens in shelter dogs from the Metropolitan Area of Bucaramanga, Santander, Colombia. An IDEXX SNAP® 4Dx Plus assay was employed to test 278 shelter dogs. From each dog, the following data were collected: municipality, age, gender, and coat length. Overall, 81.3% of the tested dogs were positive for one or more of the vector-borne pathogens. The highest prevalence observed was for Ehrlichia spp. (79.9%) in 278 shelter dogs, followed by Anaplasma spp. (36%), Dirofilaria immitis (6.5%) and Borrelia burgdorferi (2.2%). Regarding the variable age, dogs less than one year old showed a statistical association (P = 0.02) for Anaplasma spp., and short-haired dogs showed a statistical association (P = 0.03) for D. immitis. The present study provides current information on the seroprevalence of vector-borne pathogens in shelter dogs from the Metropolitan Area of Bucaramanga, and these findings could be useful for control measures that should be implemented on dog populations and vector populations in the study area.
Survival in Breast Cancer Patients Compared to Non-Pregnant Controls
Authors: Cameán María Martín , Marin Ibon Jaunarena , Méndez Jose Ignacio Sánchez , Alvarez Covadonga Martí , Alegre Félix Boria , Boado Elena Martín , Zapardiel Ignacio , Gutiérrez Alicia Hernández 
Published: February 2024

Abstract

Background
Pregnancy-associated breast cancer (PABC) is a rare entity whose prognosis has previously been studied and is subject to controversy.
Methods
Survival of patients with PABC diagnosed between 2009 and 2021 with breast cancer during pregnancy or until 1 year after childbirth was compared with non-pregnant patients with breast cancer from the same period at La Paz University Hospital. Cox proportional hazards regression was used to compare disease-free (DFS) and overall (OS) survival between the groups, adjusting for grade and pathologic stage.
Results
Among the 89 included patients with breast cancer, 34 were diagnosed during pregnancy, and 55 were not pregnant. The pregnant patients were more likely to have grade 3 tumors (61.3% vs 37%, p = 0.023) and an advanced stage (pathologic stage III-IV: 44.1% vs 17.6%, p = 0.008). Median follow-up was 47 months for the pregnant group and 46 months for the control group. After adjustments for tumor grade and pathologic stage, OS was comparable between the groups (HR 2.03; 95% CI 0.61 to 6.79; P = 0.25).
Conclusions
The outcome of women diagnosed with PABC is comparable to young non-pregnant controls. However, it should be taken into account that PABC has a more aggressive phenotype.
Psychometric evidence of the International Index of Erectile Function (IIEF) in a Chilean representative sample
Authors: Quintana Gonzalo R. , Ponce Fernando P. 
Published: February 2024

Abstract
Amongst many psychometric instruments to measure male sexual dysfunctions, the International Index of Erectile Function (IIEF) stands out for its utility and widespread use. However, its internal latent structure lacks consistency across studies. Furthermore, studies have yet to address its measurement invariance evidence. Moreover, no formal validation of the IIEF has been conducted in Chile. Therefore, the following study aimed to comprehensively evaluate its psychometric evidence in a Chilean sample of men and determine its measurement invariance across relationship status, age groups, and paraphilic interests. A sample of 650 sexually active males was derived from a broader Chilean study (CSSS). We used a confirmatory factor analysis to determine its structural validity, sexual satisfaction dimensions to establish its criterion-related validity, and Cronbach's alpha and McDonald's omega to assess the reliability of its scores. Results supported the five-factor latent solution. Meanwhile, criterion-related validity revealed subtle yet significant differences in sexual satisfaction, with younger men displaying higher satisfaction in various sexual domains, whereas middle-aged men and those in a relationship showed better sexual function. Finally, the IIEF was invariant across relationship status, age groups, and paraphilic interests at the factor covariance level. Limitations included a lack of clinical population and a sample predominantly younger, cisgender, and heterosexual. Altogether, this study highlights the IIEF's suitability for assessing male sexual function in Chilean male populations across diverse sociodemographic characteristics. Future research efforts should focus on expanding sample diversity, including clinical populations.
Exploring the causal relationship between 91 inflammatory cytokines and two subtypes of rheumatoid arthritis: a bidirectional two-sample Mendelian randomization study
Authors: Gao Wenjie , Chen Jianan , Zheng Muxu , Liao Nianchun , Liu Song , Shi Huihong , Hu Wenjun , Chen Yanbo , Huang Dongsheng , Lin Youxi , Liang Anjing 
Published: February 2024

Abstract
Objective
In previous studies, the occurrence of rheumatoid arthritis (RA) has been reported to be associated with various inflammatory cytokines. This research aims to investigate the causal relationship between 91 inflammatory cytokines and two distinct subtypes of RA, employing bidirectional two-sample Mendelian Randomization (MR) analysis.
Methods
Utilizing genetic summary data from a publicly available genome-wide association study (GWAS), we examined the genetic variations of 91 inflammatory cytokines in 14,824 individuals of European ancestry. RA genetic variant data were sourced from the FinnGen consortium, including 4,290 cases and 368,362 controls in the seropositive RA (SPRA) cohort, and 3,877 cases and 285,035 controls in the seronegative RA (SNRA) cohort. Primary analysis employed the Inverse Variance Weighted (IVW) method, with supplementary methods including MR Egger, Weighted Median (WM), Simple Mode, and Weighted Mode to enhance result robustness. Sensitivity analysis was conducted for result reliability.
Results
IVW analysis revealed elevated levels of natural killer cell receptor 2B4 (CD244), FMS-related tyrosine kinase 3 ligand (FLT3LG), interleukin (IL)-7, and tumor necrosis factor (TNF) significantly associated with an increased risk of SPRA. Lower levels of IL-6 were associated with increased risks of SNRA, while higher levels of IL-7 were related to an increased risk of SNRA. Reverse MR analysis suggested SNRA might downregulate levels of Fractalkine (CX3CL1).
Conclusions
This study enhances our understanding of the correlation between inflammatory cytokines and RA, providing novel insights into the etiology, diagnosis, and treatment of two RA subtypes.
Genetic Diversity of Faba Bean (Vicia faba L.) Based on Local Knowledge and Inter Simple Sequence Repeats in North-East Amhara National Regional State, Ethiopia
Authors: Hailu Faris , Legesse Tsinat , Dejen Asmare , Feyissa Teleye , Adane Metadel 
Published: February 2024

Abstract

Ethiopia is center of diversity and one of the top nine agro-ecological regions for faba bean growth with high diversity. This high diversity is an opportunity for the improvement of the crop. However, the farmer named landraces and their molecular base variation was not well studied. Therefore, the objective of this study was to analyze the genetic diversity of farmers’ faba bean varieties in different agro-ecologies (sm3; tepid sub-moist mid highlands and sm4; wet sub-moist mid highlands) of North-East Amhara National Regional State, Ethiopia. The collection for the strata is considered as populations to analyze genetic base variation through inter simple sequence repeats (ISSR) genetic marker. Six varieties were used in the study areas among which four were local and the rest two were released as high yielding (Mert bakela) and water logging resistant (yeweha bakela). Six plants from each of the four populations were analyzed using 9 ISSR primers which amplified 113 loci of which 112 were polymorphic. Primer 812, 854 and 881 had produced 15 loci each and a total of 168 bands. Primer 812 had the highest resolving power, 7.32; primer 854 had the highest band informativeness, 0.49 and primer 881 had the highest polymorphic information content, 0.95. Population 2 that is of Sm3-South Wollo stratum showed the highest spatial diversity (4.615385) and Shannon-Weavers’ Diversity (1.364). Five out of six faba bean varieties were found in population 2 and three of them were unique. However, the most abundant local faba bean varieties, yehabesha and yeferenje bakela, had higher genetic diversity. Especially Yehabesha bakela had different unique futures including wider rating for disease resistance compared to the other most abundant released variety, yeweha bakela, (p = 0.01828).
Non-relapse mortality after CAR T-cell therapy: A systematic review and meta-analysis of 7,788 lymphoma and myeloma patients
Authors: Rejeski Kai , Santos David Cordas dos , Tix Tobias , Shouval Roni , Cliff Edward Scheffer , Theurich Sebastian , von Bergwelt-Baildon Michael , Ghobrial Irene , Subklewe Marion , Perales Miguel-Angel 
Published: February 2024

Abstract

While CAR-T therapy represents a transformative immunotherapy, it is also associated with distinct toxicities that contribute to morbidity and mortality. In this systematic review and meta-analysis, we searched MEDLINE, Embase and CINAHL for reports of non-relapse mortality (NRM) following CAR-T in lymphoma and myeloma, published until 09/2023. Cumulative incidence rates of NRM and causes/numbers of death were extracted. NRM point estimates were analyzed using fixed effect models. We identified 7,788 patients across 16 clinical trials and 32 real-world studies. After a median follow-up of 12.9 months, the overall NRM rate was 7.5% (95%CI 6.9-8.1%). NRM point estimates were related to the disease entity, CAR-T product and costimulatory domain. Of 582 reported non-relapse deaths, nearly half were attributed to infections, followed by cardiovascular/respiratory events (7.4%) and second malignancies (6.5%). Our findings underline the critical importance of post-CAR-T infections and support the comprehensive reporting of NRM, including specific causes and long-term outcomes.
An Innovative Strategy of Comprehensive Utilization of Tiger Nuts (Cyperus esculentus L.): Simultaneous Extraction of Oil and Glucose Syrup by Amylolysis-assisted Aqueous Extraction Process
Authors: Zhang Shiqi , Jiang Yiming , tong Yanjun , leng Juncai , Zhou Tingyi , Gao Zihan , Liu Han , Zhu Chenlu , Zhang Wenbin , Yang Ruijin 
Published: February 2024

Abstract
The tiger nut (Cyperus esculentus L.) possesses a substantial nutrition yet its industrialization process is characterized by sluggishness. Herein, we introduced a green approach to achieve simultaneous extraction of oil and glucose syrup from tiger nuts via Amylolysis-assisted Aqueous Extraction Process (AAEP). Briefly, tiger nut flour was rinsed to eliminate non-starch polysaccharides and separate the majority of the oil (64.02 %). Followed by liquefaction with α-amylase (AMY), and saccharification with amyloglucosidase (AMG) and pullulanase. Under optimal conditions (AMY dosage: 40 U/g; AMG and pullulanase dosages: 200 U/g and 10 U/g respectively; pH=6.0 during liquefaction at a temperature of 95 oC for 30 min; pH=5.5 during saccharification at a temperature of 55 oC for 150 min; the solid-liquid ratio of 1:5), the AAEP method achieved an oil yield of 89.84 % along with a glucose syrup yield of 89.41 %. Confocal laser scanning microscopy (CLSM) results demonstrated that starch hydrolysis promoted the release of encapsulated oil, which enhanced the extraction efficiency of oil. Overall, our findings highlight that AAEP is an effective industrial approach facilitating comprehensive utilization of tiger nuts.