bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-decadal coastal change detection using remote sensing: the Mediterranean coast of Egypt between El-Dabaa and Ras El-Hekma
Authors: El-Masry Esraa A. , Magdy Asmaa , El-Gamal Ayman , Mahmoud Baher , El-Sayed Mahmoud Kh. 
Published: January 2024

AbstractA key source of information for many decision support systems is identifying land use and land cover (LULC) based on remote sensing data. Land conservation, sustainable development, and water resource management all benefit from the knowledge obtained from detecting changes in land use and land cover. The present study aims to investigate the multi-decadal coastal change detection for Ras El-Hekma and El-Dabaa area along the Mediterranean coast of Egypt, a multi-sectoral development area. Besides, the superiority of the area is highly dependent on its proximity to three development projects: the tourism and urban growth pole at Ras El-Hekma, the beachfront Alamain New Mega City, and the Nuclear Power Plant at El Dabaa. This study utilized multi-spectral Landsat satellite images covering 1990, 2010, and 2020 to perceive the post-classification change detection analysis of the land use and land cover changes (LULCC) over 30 years. The results of the supervised classification from 1990 to 2020 showed a 47.33 km2 (4.13%) expansion of the agricultural land area, whereas the bare soil land area shrunk to 73.13 km2 (6.24%). On the other hand, the built-up activities in the area launched in 2010 and escalated to 20.51 km2(1.77%) in 2020. The change in land use reveals the shift in the economic growth pattern in the last decade toward tourism and urban development. Meanwhile, it indicates that no conflict has yet arisen regarding the land use between the expanded socioeconomic main sectors (i.e., agriculture, and tourism). Therefore, the best practices of land use management and active participation of the stakeholders and the local community should be enhanced to achieve sustainability and avoid future conflicts. An area-specific plan including resource conservation measures and the provision of livelihood alternatives should be formulated within the National Integrated Coastal Zone Management (ICZM) plan with the participation of the main stakeholders and beneficiaries. The findings of the present work may be considered useful for sustainable management and supportive to the decision-making process for the sustainable development of this area.
Solvent Extraction of PDMS Tubing as a New Method for the Capture of Volatile Organic Compounds from Headspace
Authors: Thomas Gareth , Caulfield John , Nikolaeva-Reynolds Lucia , Birkett Michael A. , Vuts József 
Published: January 2024

AbstractPolydimethylsiloxane (PDMS) tubing is increasingly being used to collect volatile organic compounds (VOCs) from static biological headspace. However, analysis of VOCs collected using PDMS tubing often deploys thermal desorption, where samples are considered as ‘one-offs’ and cannot be used in multiple experiments. In this study, we developed a static headspace VOC collection method using PDMS tubing which is solvent-based, meaning that VOC extracts can be used multiple times and can be linked to biological activity. Using a synthetic blend containing a range of known semiochemicals (allyl isothiocyanate, (Z)-3-hexen-1-ol, 1-octen-3-one, nonanal, (E)-anethol, (S)-bornyl acetate, (E)-caryophyllene and pentadecane) with differing chemical and physicochemical properties, VOCs were collected in static headspace by exposure to PDMS tubing with differing doses, sampling times and lengths. In a second experiment, VOCs from oranges were collected using PDMS sampling of static headspace versus dynamic headspace collection. VOCs were eluted with diethyl ether and analysed using gas chromatography – flame ionization detector (GC-FID) and coupled GC – mass spectrometry. GC-FID analysis of collected samples showed that longer PDMS tubes captured significantly greater quantities of compounds than shorter tubes, and that sampling duration significantly altered the recovery of all tested compounds. Moreover, greater quantities of compounds were recovered from closed compared to open systems. Finally, analysis of orange headspace VOCs showed no qualitative differences in VOCs recovered compared to dynamic headspace collections, although quantities sampled using PDMS tubing were lower. In summary, extraction of PDMS tubing with diethyl ether solvent captures VOCs from the headspace of synthetic blends and biological samples, and the resulting extracts can be used for multiple experiments linking VOC content to biological activity.
A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks
Authors: Vághy Mihály A. , Otero-Muras Irene , Pájaro Manuel , Szederkényi Gábor 
Published: January 2024

AbstractIn this paper, a finite volume discretization scheme for partial integro-differential equations (PIDEs) describing the temporal evolution of protein distribution in gene regulatory networks is proposed. It is shown that the obtained set of ODEs can be formally represented as a compartmental kinetic system with a strongly connected reaction graph. This allows the application of the theory of nonnegative and compartmental systems for the qualitative analysis of the approximating dynamics. In this framework, it is straightforward to show the existence, uniqueness and stability of equilibria. Moreover, the computation of the stationary probability distribution can be traced back to the solution of linear equations. The discretization scheme is presented for one and multiple dimensional models separately. Illustrative computational examples show the precision of the approach, and good agreement with previous results in the literature.
Informational Postcards Increase Engagement with Remote Monitoring Among Veterans with Pacemakers and Implantable Cardioverter-Defibrillators: a Stepped-Wedge Randomized Controlled Trial
Authors: McLaughlin Megan M. , Raitt Merritt H. , Tarasovsky Gary , Whooley Mary A. , Dhruva Sanket S. 
Published: January 2024

Abstract
Background
Remote monitoring (RM) of pacemakers and implantable cardioverter-defibrillators (ICDs) reduces morbidity and mortality. However, many patients are not adherent to RM.

Objective
To test the effect of informational postcards on RM adherence.

Design/Patients
Stepped-wedge randomized controlled trial among Veterans with pacemakers and ICDs.

Intervention
In wave 1, Veterans who had sent at least 1 transmission within the past 2 years but had become non-adherent were randomly assigned to receive a postcard or no postcard. Those receiving postcards were randomized to 1 of 2 messages: (1) a”warning” postcard describing risks of non-adherence or (2) an “encouraging” postcard describing benefits of adherence. In wave 2, Veterans who had either not received a postcard in wave 1 or had since become non-adherent were mailed a postcard (again, randomized to 1 of 2 messages). Patients who did not send an RM transmission within 1 month were mailed a second, identical postcard.

Main Measures
Transmission within 70 days.

Key Results
Overall, 6351 Veterans were included. In waves 1 and 2, postcards were mailed to 5657 Veterans (2821 “warning” messages and 2836 “encouraging” messages). Wave 1 included 2178 Veterans as controls (i.e., not mailed a postcard), some of whom received a postcard in wave 2 if they remained non-adherent. In wave 2, 3473 postcards were sent. Of the 5657 patients mailed a postcard, 2756 (48.7%) sent an RM transmission within 70 days, compared to 530 (24.3%) of 2178 controls (absolute difference 24.4%, 95% confidence interval [CI] 22.2%, 26.6%). Of those who sent a transmission, 71.8% did so after the first postcard. Transmission rates at 70 days did not significantly differ between “warning” and “encouraging” messages (odds ratio 1.04, 95% CI 0.92, 1.18).

Conclusions
Informational postcards led to a 24.4% absolute increase in adherence at 70 days among Veterans with pacemakers and ICDs who were non-adherent to RM.
Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer
Authors: Huang Yafei , Su Ting , Duan Qiuting , Wei Xiangcong , Fan Xin , Wan Jinxiu , Liu Luping , Dian Ziqin , Zhang Guiqian , Sun Yi , Zhou Tao , Xu Ya 
Published: January 2024

Abstract
Purpose
Colorectal cancer (CRC) is one of the most common malignancies, with a high incidence and mortality worldwide. Methylated Septin 9 (mSEPT9) has been used clinically as an auxiliary tool for CRC screening. The aim of the present study was to investigate the association of the methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism with the risk of CRC and the methylation status of Septin 9 in CRC.

Methods
Information of 540 patients with a confirmed diagnosis of CRC and with a physical examination were utilized to assess the association of the MTHFR rs1801133 polymorphism with CRC and the methylation of SEPT9. MTHFR rs1801133 polymorphism was genotyped using polymerase chain reaction (PCR). The commercial Septin 9 Gene Methylation(mSEPT9) Detection Kit was used for plasma SEPT9 methylation analysis.

Results
Among 540 patients, 61.48% were men and the median age was 54.47 ± 13.14. 65.37% of all colorectal tumors developed in the rectum. 195 patients had negative mSEPT9 methylation, while 345 had positive results. 87 individuals with stage I, 90 with stage II, 287 with stage III, and 76 with stage IV colorectal cancer were included in the sample. The results demonstrated that the positivity rate and degree of methylation of mSEPT9 were remarkably higher in patients with more advanced TNM stages than in those with less advanced stages. The frequencies of the MTHFR rs1801133 CC genotype and allele C carriers in patients with CRC were significantly higher than those in healthy individuals (P = 0.006 and P = 0.001, respectively). The positivity rate of the mSEPT9 assay was significantly higher among the MTHFR rs1801133 TT genotype and allele T carriers than among the CC and allele C carriers respectively. The MTHFR rs1801133 TT genotype and allele T carriers were positively associated with the methylation of SEPT9 (OR = 3.320, 95% CI 1.485–7.424, P = 0.003 and OR = 1.783, 95% CI 1.056–3.010, P = 0.030, respectively).

Conclusion
In conclusion, individuals harboring the MTHFR rs1801133 CC genotype had a higher risk of CRC and the MTHFR rs1801133 TT carriers were more susceptible to Septin 9 gene methylation.
An algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
Authors: Yu Ming-Lung , Tai Chi‐Ming , Mo Lein-Ray , Kuo Hsing-Tao , Huang Chung-Feng , Tseng Kuo-Chih , Lo Ching-Chu , Bair Ming-Jong , Wang Szu-Jen , Huang Jee-Fu , Yeh Ming-Lun , Chen Chun-Ting , Tsai Ming-Chang , Huang Chien-Wei , Lee Pei-Lun , Yang Tzeng-Hue , Huang Yi-Hsiang , Chong Lee-Won , Chen Chien-Lin , Yang Chi-Chieh , Hung Chao-Hung , Yang Sheng‐Shun , Cheng Pin-Nan , Hsieh Tsai-Yuan , Hu Jui-Ting , Wu Wen-Chih , Cheng Chien-Yu , Chen Guei-Ying , Zhou Guo-Xiong , Tsai Wei-Lun , Kao Chien-Neng , Lin Chih-Lang , Wang Chia-Chi , Lin Ta-Ya , Lin Chih‐Lin , Su Wei-Wen , Lee Tzong-Hsi , Chang Te-Sheng , Liu Chun-Jen , Dai Chia-Yen , Chen Chi-Yi , Kao Jia-Horng , Lin Han-Chieh , Chuang Wan-Long , Peng Cheng-Yuan 
Published: January 2024

Abstract
Background
Both European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) guidelines recommend simplified hepatitis C virus (HCV) treatment with pan-genotypic sofosbuvir/velpatasvir or glecaprevir/pibrentasvir for eligible patients. This observational study used real-world data to assess these regimens’ safety in eligible patients and develop an algorithm to identify patients suitable for simplified treatment by non-specialists.

Methods
7,677 HCV-infected patients from Taiwan Hepatitis C Registry (TACR) who received at least one dose of sofosbuvir/velpatasvir or glecaprevir/pibrentasvir, and fulfilled the EASL/AASLD-IDSA criteria for simplified treatment were analyzed. Multivariate analysis was conducted on patient characteristics and safety data.

Results
Overall, 92.8% (7,128/7,677) of patients achieved sustained virological response and only 1.9% (146/7,677) experienced Grades 2–4 laboratory abnormalities in key liver function parameters (alanine aminotransferase, aspartate aminotransferase, and total bilirubin), with only 18 patients (0.23%) experiencing Grades 3–4 abnormalities. Age > 70 years old, presence of hepatocellular carcinoma, total bilirubin > 1.2 mg/dL, estimated glomerular filtration rate < 60 mL/min/1.73 m2, and Fibrosis-4 > 3.25 were associated with higher risks of Grades 2–4 abnormalities. Patients with any of these had an odds of 4.53 times than that of those without in developing Grades 2–4 abnormalities (p < 0.01).

Conclusions
Real-world data from Taiwan confirmed that simplified HCV treatment for eligible patients with pan-genotypic regimens is effective and well tolerated. The TACR algorithm, developed based on this study’s results, can further identify patients who can be safely managed by non-specialist care.

Graphical Abstract
Facets of Trust and Distrust in Collaborative Robots at the Workplace: Towards a Multidimensional and Relational Conceptualisation
Authors: Kopp Tobias 
Published: January 2024

Abstract
The relevance of trust on the road to successful human-robot interaction is widely acknowledged. Thereby, trust is commonly understood as a monolithic concept characterising dyadic relations between a human and a robot. However, this conceptualisation seems oversimplified and neglects the specific interaction context. In a multidisciplinary approach, this conceptual analysis synthesizes sociological notions of trust and distrust, psychological trust models, and ideas of philosophers of technology in order to pave the way for a multidimensional, relational and context-sensitive conceptualisation of human-robot trust and distrust. In this vein, trust is characterised functionally as a mechanism to cope with environmental complexity when dealing with ambiguously perceived hybrid robots such as collaborative robots, which enable human-robot interactions without physical separation in the workplace context. Common definitions of trust in the HRI context emphasise that trust is based on concrete expectations regarding individual goals. Therefore, I propose a three-dimensional notion of trust that binds trust to a reference object and accounts for various coexisting goals at the workplace. Furthermore, the assumption that robots represent trustees in a narrower sense is challenged by unfolding influential relational networks of trust within the organisational context. In terms of practical implications, trust is distinguished from acceptance and actual technology usage, which may be promoted by trust, but are strongly influenced by contextual moderating factors. In addition, theoretical arguments for considering distrust not only as the opposite of trust, but as an alternative and coexisting complexity reduction mechanism are outlined. Finally, the article presents key conclusions and future research avenues.
Application of the quality of recovery-40 questionnaire to evaluate the effectiveness of enhanced recovery after surgery protocols in gastric cancer
Authors: Chen Yeyang , Liu Siyu , Li Bopei , Lin Rujing , Lai Weikun , Liu Dejun , Wang Zhen , Liu Jinlu , Qin Xingan , Wu Xianghua , Li Jiehua , Jia Kui , Chen Junqiang 
Published: January 2024

AbstractPatient reported outcomes is currently considered to be an important supplement to evaluate the effectiveness of enhanced recovery after surgery (ERAS) clinical practice. The Quality of Recovery-40 Questionnaire (QoR-40) is one of the most frequently used and validation tool to assess the subjective feelings of quality of life after surgery. The present study aimed to use the QoR-40 to evaluate the effectiveness of ERAS protocols in gastric cancer from the perspective of patient-reported quality of recovery. The study was designed as a prospective, non-randomized clinical trial, conducted in a single center. Patients in our hospital who were scheduled to undergo radical surgery for gastric cancer were divided into ERAS group and control group (Contr group). The QoR-40 were administered one day before surgery (Baseline) and on postoperative day 1, 3, 6, and 30. The difference in QoR-40 scores between the ERAS and Contr groups was compared by repeated-measures ANOVA. A total of 200 patients completed the study, including 100 patients in the ERAS group and 100 patients in the Contr group. The Baseline time point QoR-40 scores of the ERAS and Contr groups were 179.68 ± 14.46 and 180.12 ± 17.12, respectively, and no significant difference was noted between the two groups (p = 0.845). The postoperative QoR-40 score of the ERAS group was significantly higher than that of the Contr group, and the difference was statistically significant (p = 0.006). This study demonstrated that, in terms of patient-reported quality of recovery, the postoperative recovery effect of ERAS protocols in gastric cancer is significantly better than that of the traditional treatment model.
A nomogram for predicting lymph nodes metastasis at the inferior mesenteric artery in rectal cancer: a retrospective case–control study
Authors: Xu Chunhao , Huang Qiaoyi , Hu Yunhuang , Ye Kai , Xu Jianhua 
Published: January 2024

AbstractAccording to past and current literature, metastasis of the lymph nodes at the inferior mesenteric artery (IMA-LN), also known as 253LN of colorectal cancer has been seldom investigated. To date, there are still controversies on whether the 253LN need to be routinely cleaned. Using specific criteria, 347 patients who underwent radical resection for rectal cancer between April 2019 and July 2022 were selected for the study. Logistic regression was used to determine the likelihood that a patient may suffer 253LN metastasis, and a nomogram for 253LN metastasis subsequently developed. The c-index and calibration curve were used to evaluate precision and discrimination in the nomogram, and the appropriateness of the final nomogram for the clinical setting determined using decision curve analysis (DCA). 253LN metastases appeared in the pathological specimens of 29 (8.4%) of the selected patients. Logistic regression showed that preoperative parameters including serum carcinoembryonic antigen (CEA) value ( > 5 ng / ml, OR = 2.894, P = 0.023), distance from anal margin (> 9 cm, OR = 2.406, P = 0.045) and degree of differentiation (poor, OR = 9.712, P < 0.001) were significantly associated with 253LN metastasis. A nomogram to predict 253LN metastasis in rectal cancer was developed and showed considerable discrimination and good precision (c-index = 0.750). Furthermore, DCA confirmed that the nomogram has some feasibility for the clinical environment. Clinicopathological and radiological patient data can be pivotal for making surgical decisions relating to 253LN metastasis. A nomogram was developed using this data, providing an objective method that can significantly improve prognoses in colorectal cancer.
The Influence of Rotational Discontinuities on the Formation of Reconnected Structures at Collisionless Shocks—Hybrid Simulations
Authors: Steinvall K. , Gingell I. 
Published: January 2024

AbstractRecent simulations and in‐situ observations have shown that magnetic reconnection is an active dissipation mechanism in the transition region of collisionless shocks. The generation mechanisms and upstream conditions enabling reconnection have been studied numerically. However, these numerical studies have been limited to the case of a steady, uniform upstream. The effect upstream discontinuities have on shock reconnection remains poorly understood. Here, we use local hybrid (fluid electron, particle ion) simulations with time‐varying upstream conditions to study the influence upstream rotational discontinuities (RDs) have on the formation of reconnected magnetic structures in the shock transition region. Our results show that bursts of reconnection can occur when RDs interact with the shock. This effect is much more significant at initially quasi‐parallel shocks than quasi‐perpendicular shocks, as the interaction between the RDs and the foreshock (only present in the quasi‐parallel case) can lead to the generation of foreshock bubbles, in which we observe an enhanced reconnection occurrence. The enhanced fluxes of accelerated ions within the foreshock bubble are likely a contributing factor to the increased reconnection occurrence. In addition, we find that the RDs with large magnetic shear are prone to reconnect upon reaching the shock, resulting in the generation of large magnetic islands. Our findings illustrate that upstream discontinuities can significantly increase the amount of reconnected magnetic structures at the bow shock, suggesting that reconnection might be a particularly important dissipation mechanism during periods of dynamic upstream conditions.
CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways
Authors: Im Joo-Young , Kim Soo Jin , Park Jong-Lyul , Han Tae-Hee , Kim Woo-il , Kim Inhyub , Ko Bomin , Chun So-Young , Kang Mi-Jung , Kim Bo-Kyung , Jeon Sol A. , Kim Seon-Kyu , Ryu Incheol , Kim Seon-Young , Nam Ki-Hoan , Hwang Inah , Ban Hyun Seung , Won Misun 
Published: January 2024

AbstractCytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R3 expression is downregulated in human lung cancer cell lines and tissues. Adenoviral overexpression of CYB5R3 suppresses lung cancer cell growth in vitro and in vivo. However, CYB5R3 deficiency promotes tumorigenesis and metastasis in mouse models. Transcriptome analysis revealed that apoptosis- and endoplasmic reticulum (ER) stress-related genes are upregulated in CYB5R3-overexpressing lung cancer cells. Metabolomic analysis revealed that CYB5R3 overexpression increased the production of nicotinamide adenine dinucleotide (NAD+) and oxidized glutathione (GSSG). Ectopic CYB5R3 is mainly localized in the ER, where CYB5R3-dependent ER stress signaling is induced via activation of protein kinase RNA-like ER kinase (PERK) and inositol-requiring enzyme 1 alpha (IRE1α). Moreover, NAD+ activates poly (ADP-ribose) polymerase16 (PARP16), an ER-resident protein, to promote ADP-ribosylation of PERK and IRE1α and induce ER stress. In addition, CYB5R3 induces the generation of reactive oxygen species and caspase-9-dependent intrinsic cell death. Our findings highlight the importance of CYB5R3 as a tumor suppressor for the development of CYB5R3-based therapeutics for lung cancer.