bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kernel-, mean-, and noise-marginalized Gaussian processes for exoplanet transits andH0 inference
Authors: Kroupa Namu , Yallup David , Handley Will , Hobson Michael 
Published: January 2024

ABSTRACTUsing a fully Bayesian approach, Gaussian process regression is extended to include marginalization over the kernel choice and hyperparameters. In addition, Bayesian model comparison via the evidence enables direct kernel comparison. The calculation of the joint posterior was implemented with a transdimensional sampler which simultaneously samples over the discrete kernel choice and their hyperparameters by embedding these in a higher dimensional space, from which samples are taken using nested sampling. Kernel recovery and mean function inference were explored on synthetic data from exoplanet transit light-curve simulations. Subsequently, the method was extended to marginalization over mean functions and noise models and applied to the inference of the present-day Hubble parameter, H0, from real measurements of the Hubble parameter as a function of redshift, derived from the cosmologically model-independent cosmic chronometer and lambda-cold dark matter-dependent baryon acoustic oscillation observations. The inferred H0 values from the cosmic chronometers, baryon acoustic oscillations, and combined data sets are $H_0= 66 \pm 6,\, 67 \pm 10,\, \mathrm{ and}\,69 \pm 6\,\mathrm{km}\, \mathrm{s}^{-1}\, \mathrm{Mpc}^{-1}$, respectively. The kernel posterior of the cosmic chronometers data set prefers a non-stationary linear kernel. Finally, the data sets are shown to be not in tension with ln R = 12.17 ± 0.02.
Gravitational torque in circumbinary discs: global radial oscillations
Authors: Cimerman Nicolas P , Rafikov Roman R 
Published: January 2024

ABSTRACT
Circumbinary discs (CBDs) arise in many astrophysical settings, including young stellar binaries and supermassive black hole binaries. Their structure is mediated by gravitational torques exerted on the disc by the central binary. The spatial distribution of the binary torque density (so-called excitation torque density) in CBDs is known to feature global large-amplitude, quasi-periodic oscillations, which are often interpreted in terms of the local resonant Lindblad torques. Here, we investigate the nature of these torque oscillations using 2D, inviscid hydrodynamic simulations and theoretical calculations. We show that torque oscillations arise due to the gravitational coupling of the binary potential to the density waves launched near the inner cavity and freely propagating out in the disc. We provide analytical predictions for the radial periodicity of the torque density oscillations and verify them with simulations, showing that disc sound speed and the multiplicity of the density wave spiral arms are the key factors setting the radial structure of the oscillations. Resonant Lindblad torques play no direct role in determining the radial structure and periodicity of the torque oscillations and manifest themselves only by driving the density waves in the disc. We also observe the formation of vortices at the inner edge of the disc, which can provide a non-trivial contribution to the angular momentum transport in the CBD and may be involved in the development of a non-axisymmetric central cavity.
NIR spectral classification of the companion in the gamma-ray binary HESS J1832−093 as an O6 V star
Authors: van Soelen B , Bordas P , Negueruela I , de Oña Wilhelmi E , Papitto A , Ribó M 
Published: January 2024

ABSTRACT
HESS J1832−093 is a member of the rare class of gamma-ray binaries, as recently confirmed by the detection of orbitally modulated X-ray and gamma-ray emission with a period of ∼86 d. The spectral type of the massive companion star has been difficult to retrieve as there is no optical counterpart, but the system is coincident with a near-infrared source. Previous results have shown that the infrared counterpart is consistent with an O or B-type star, but a clear classification is still lacking. We observed the counterpart twice, in 2019 and 2021, with the X-Shooter spectrograph operating on the Very Large Telescope (VLT). The obtained spectra classify the counterpart as an O6 V-type star. We estimate a distance to the source of 6.7 ± 0.5 kpc, although this estimate can be severely affected by the high extinction towards the source. This new O6 V classification for the companion star in HESS J1832−093 provides further support to an apparent grouping around a given spectral type for all discovered gamma-ray binaries that contain an O-type star. This may be due to the interplay between the initial mass function and the wind momentum–luminosity relation.
Osmoregulatory physiology of the angel wing bivalve Cyrtopleura costata (Pholadidae), an estuarine intertidal burrowing mollusc
Authors: Stakowian Nicole , Freire Carolina A 
Published: January 2024

ABSTRACT
Cyrtopleura costata is a pholadid bivalve that inhabits tidal flats inside burrows c. 40 cm deep, and its visceral mass outgrows its shell significantly. Thus, unlike other bivalves, it cannot isolate its soft tissues from the external environment through complete valve closure. One can thus hypothesize that this bivalve would be inevitably more exposed and susceptible to the tidal changes in salinity. No information regarding its osmoregulatory physiology has been found in the literature. We thus investigated how its fluids would respond to seawater dilution and seawater concentration, and how its tissues would be able to keep their moisture content. Individuals of C. costata were acclimated to 30‰ and then independently exposed stepwise (1 h for each 5‰ change) to 25, 20, 15 and 10‰ or to 35, 40, 45 and 50‰. Isolated tissue slices obtained from control animals (30‰) of siphon, mantle and muscle were exposed in vitro to salines corresponding to salinities of 10, 30 and 50‰. Cyrtopleura costata responded as a typical euryhaline osmoconformer between 25 and 40‰, with haemolymph and mantle cavity water being isosmotic to the external medium. However, some ‘buffering’ of haemolymph osmolality was displayed in the most extreme salinities, 10–20‰ and 45–50‰. This could result from muscle contraction and other cellular responses, reducing ‘apparent permeability’ and diffusive fluxes; the muscle was the tissue with the highest capacity to maintain constant hydration despite significant osmotic challenge. Both in vivo and in vitro experiments indicated a higher tolerance of salinity increases than decreases. Thus, if global and local changes in climate and precipitation rates result in more frequent seawater dilution in its habitat, the area occupied by its realized niche may be reduced.
Painful snapping of the middle finger caused by hyperplasia of the ulnar lateral band: A case report
Authors: Matsuo Anna , Suzuki Taku , Kimura Hiroo , Matsumura Noboru , Iwamoto Takuji , Nakamura Masaya 
Published: January 2024

ABSTRACT
Snapping of fingers can be caused by pathologies such as stenosing flexor tenosynovitis. However, snapping symptoms in the metacarpophalangeal (MP) joint caused by hypertension and hyperplasia of the lateral band are rare. We present a 26-year-old female with symptoms of painful snapping of the middle finger. When the finger was actively flexed from the hyperextension of the MP joint, the ulnar lateral band was prominent, and a snapping phenomenon occurred. The cause of the snapping finger was considered to be tightness of the ulnar lateral band, and surgery was planned. Intraoperatively, the ulnar lateral band was tense and hyperplastic. The snapping phenomenon disappeared immediately after the resection of the lateral band. It is important to consider this condition as one of the differential diagnoses of snapping finger when the patient complains of an atypical snapping phenomenon.
Social behavior among nocturnally migrating birds revealed by automated moonwatching
Authors: Bridge Eli S , Honeycutt Wesley T , Chen Angela J , Miller Riley , Kelly Jeffrey F 
Published: January 2024

Abstract
Migrating birds often fly in group formations during the daytime, whereas at night, it is generally presumed that they fly singly. However, it is difficult to quantify group behavior during nocturnal migration as there are few means of directly observing interactions among individuals. We employed an automated form of moonwatching to estimate percentages of birds that appear to migrate in groups during the night within the Central Flyway of North America. We compared percentages of birds in groups across the spring and fall and examined overnight temporal patterns of group behavior. We found groups were rare in both seasons, never exceeding 10% of birds observed, and were almost nonexistent during the fall. We also observed an overnight pattern of group behavior in the spring wherein groups were more commonly detected early in the night and again just before migration activity ceased. This finding may be related to changes in species composition of migrants throughout the night, or alternatively, it suggests that group formation may be associated with flocking activity on the ground as groups are most prevalent when birds begin and end a night of migration.
Transcription factor LBD16 targets cell wall modification/ion transport genes in peach lateral root formation
Authors: Wu Xuelian , Wang Zhe , Du Anqi , Gao Huaifeng , Liang Jiahui , Yu Wenying , Yu Haixiang , Fan Shihao , Chen Qiuju , Guo Jian , Xiao Yuansong , Peng Futian 
Published: January 2024

Abstract
LATERAL ORGAN BOUNDARIES DOMAIN/ASYMMETRIC LEAVES2-LIKEs (LBDs/ASLs) are plant-specific transcription factors that function downstream of auxin-regulated lateral root (LR) formation. Our previous research found that PpLBD16 positively regulates peach (Prunus persica) LR formation. However, the downstream regulatory network and target genes of PpLBD16 are still largely unknown. Here, we constructed a PpLBD16 homologous overexpression line and a PpLBD16 silenced line. We found that overexpressing PpLBD16 promoted peach root initiation, while silencing PpLBD16 inhibited peach root formation. Through RNA sequencing (RNA-seq) analysis of roots from PpLBD16 overexpression and silenced lines, we discovered that genes positively regulated by PpLBD16 were closely related to cell wall synthesis and degradation, ion/substance transport, and ion binding and homeostasis. To further detect the binding motifs and potential target genes of PpLBD16, we performed DNA-affinity purification sequencing (DAP-seq) analysis in vitro. PpLBD16 preferentially bound to CCNGAAANNNNGG (MEME-1), [C/T]TTCT[C/T][T/C] (MEME-2), and GCGGCGG (ABR1) motifs. By combined analysis of RNA-seq and DAP-seq data, we screened candidate target genes for PpLBD16. We demonstrated that PpLBD16 bound and activated the cell wall modification-related genes EXPANSIN-B2 (PpEXPB2) and SUBTILISIN-LIKE PROTEASE 1.7 (PpSBT1.7), the ion transport-related gene CYCLIC NUCLEOTIDE-GATED ION CHANNEL 1 (PpCNGC1) and the polyphenol oxidase (PPO)-encoding gene PpPPO, thereby controlling peach root organogenesis and promoting LR formation. Moreover, our results displayed that PpLBD16 and its target genes are involved in peach LR primordia development. Overall, this work reveals the downstream regulatory network and target genes of PpLBD16, providing insights into the molecular network of LBD16-mediated LR development.
Mechanical advantage makes stomatal opening speed a function of evaporative demand
Authors: Pichaco Javier , Manandhar Anju , McAdam Scott A M 
Published: January 2024

Abstract
Stomatal opening in the light, observed in nearly all vascular land plants, is essential for providing access to atmospheric CO2 for photosynthesis. The speed of stomatal opening in the light is critical for maximizing carbon gain in environments in which light intensity changes, yet we have little understanding of how other environmental signals, particularly evaporative demand driven by vapor pressure deficit (VPD) influences the kinetics of this response. In angiosperms, and some fern species from the family Marsileaceae, a mechanical interaction between the guard cells and the epidermal cells determines the aperture of the pore. Here, we examine whether this mechanical interaction influences the speed of stomatal opening in the light. To test this, we investigated the speed of stomatal opening in response to light across a range of VPDs in seven plant species spanning the evolutionary diversity of guard cell and epidermal cell mechanical interactions. We found that stomatal opening speed is a function of evaporative demand in angiosperm species and Marsilea, which have guard cell and epidermal cell mechanical interactions. Stomatal opening speeds did not change across a range of VPD in species of gymnosperm and fern, which do not have guard cell mechanical interactions with the epidermis. We find that guard cell and epidermal cell mechanical interactions may play a key role in regulating stomatal responsiveness to light. These results provide valuable insight into the adaptive relevance of mechanical advantage.
What can multiple causes of death tell about cardiovascular mortality during COVID-19 pandemic in the United States?
Authors: Ukolova Elizaveta , Burcin Boris 
Published: January 2024

Abstract

Background
The COVID-19 pandemic may have caused an underestimation of cardiovascular disease (CVD) mortality, as COVID-19 was predominantly recorded as the underlying cause of death. This study investigates CVD-related excess mortality and recording of CVD on the death certificates during 2020–2021, considering underlying (underlying causes of death (UCD)), immediate and contributory causes.

Methods
We utilize US Multiple-Cause-of-Death Mortality Data. Excess deaths are assessed by comparing actual 2020–2021 deaths with Seasonal Autoregressive Integrated Moving Average model predictions. To understand changes in cause-of-death recording, we use the standardized ratio of multiple to underlying causes (SRMU).

Results
Excess CVD mortality is most prominent in contributory causes, including hypertensive disease, essential hypertension, and acute myocardial infarction. While excess of contributory CVDs generally decreased in 2021, acute myocardial infarction, pulmonary heart diseases and other circulatory diseases showed a continual increase. Changes in SRMU from 2020 to 2021, compared to 2010–2019, reveal shifts in coding practices, particularly for pulmonary heart, cerebrovascular diseases, non-rheumatic valve disorders and heart failure.

Conclusions
The COVID-19 pandemic has significantly increased CVD-related mortality, which is not fully captured in conventional analyses based solely on the UCD. The trend of coding CVDs as non-underlying causes of death accelerated during 2020–2021. Multiple-causes-of-death should be employed to evaluate mortality when new leading cause of death emerges.
Lupus enteritis: a narrative review
Authors: Muñoz-Urbano Marcela , Sangle Shirish , D’Cruz David P 
Published: January 2024

Abstract
Lupus enteritis (LE) is a rare manifestation of systemic lupus erythematosus. The pathophysiology of LE has not been fully elucidated, although inflammatory and thrombotic processes are likely important factors. The underlying pathophysiological mechanisms may depend on which portion of the intestine is affected. Over half of the patients with LE also present with renal or haematological complications. The diagnosis of LE is based on clinical, histopathological and imaging findings; abdominal computed tomography (CT) is the gold standard in diagnosis. Abdominal CT can also identify factors that predict complications and could potentially guide pharmacological and nutritional management. Timely identification and prompt treatment initiation are paramount to avoid life and organ threatening complications. Glucocorticoids are often the first-line treatment. Additional therapy including immunosuppressive therapy is utilised on a case-by-case basis as there are no clinical trials to define the optimal therapeutic approach. Surgical intervention may be needed especially if there is bowel perforation or peritonitis. In general, the prognosis of LE is good.
S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium
Authors: van Kooten Nienke J T , Blom Arjen B , Teunissen van Manen Iris J , Theeuwes Wessel F , Roth Johannes , Gorris Mark A J , Walgreen Birgitte , Sloetjes Annet W , Helsen Monique M , Vitters Elly L , van Lent Peter L E M , Koëter Sander , van der Kraan Peter M , Vogl Thomas , van den Bosch Martijn H J 
Published: January 2024

Abstract

Objectives
Macrophages are key orchestrators of the osteoarthritis (OA)-associated inflammatory response. Macrophage phenotype is dependent on environmental cues like the inflammatory factor S100A8/A9. Here, we investigated how S100A9 exposure during monocyte-to-macrophage differentiation affects macrophage phenotype and function.

Methods
OA synovium cellular composition was determined using flow cytometry and multiplex immunohistochemistry. Healthy donor monocytes were differentiated towards M1- and M2-like macrophages in the presence of S100A9. Macrophage markers were measured using flow cytometry, and phagocytic activity was determined using pHrodo Red Zymosan A BioParticles. Gene expression was determined using qPCR. Protein secretion was measured using Luminex multianalyte analysis and ELISA.

Results
Macrophages were the dominant leucocyte subpopulation in OA synovium. They mainly presented with an M2-like phenotype, although the majority also expressed M1-like macrophage markers. Long-term exposure to S100A9 during monocyte-to-macrophage differentiation increased M2-like macrophage markers CD163 and CD206 in M1-like and M2-like differentiated cells. In addition, M1-like macrophage markers were increased in M1-like, but decreased in M2-like differentiated macrophages. In agreement with this mixed phenotype, S100A9 stimulation modestly increased expression and secretion of pro-inflammatory markers and catabolic enzymes, but also increased expression and secretion of anti-inflammatory/anabolic markers. In accordance with the upregulation of M2-like macrophage markers, S100A9 increased phagocytic activity. Finally, we indeed observed a strong association between S100A8 and S100A9 expression and the M2-like/M1-like macrophage ratio in end-stage OA synovium.

Conclusion
Chronic S100A8/A9 exposure during monocyte-to-macrophage differentiation favours differentiation towards an M2-like macrophage phenotype. The properties of these cells could help explain the catabolic/anabolic dualism in established OA joints with low-grade inflammation.
Closing the loop without reinventing the wheel: public procurement for innovation promoting a circular economy
Authors: Grimbert Stephanie Francis , Zabala-Iturriagagoitia Jon Mikel 
Published: January 2024

Abstract
This theoretical paper adopts a procedural perspective to identify the challenges associated with the implementation of the full scope of approaches to circular public procurement (CPP). We contend that beyond considering CPP from a substantive standpoint (i.e. the procurement affects outside of the organization), adopting a procedural perspective (i.e. the procurement affects inside an organization) to public procurement can pave the way for reflecting transversally on how CPP can borrow from public procurement for innovation (PPI). Building on the challenges identified in the literature on CPP, we identify that PPI can contribute to consolidating CPP through such mechanisms as market engagement and intermediation, functional specifications, and coordinated unbundling. We provide illustrations for each of the identified procedural contributions of PPI to CPP derived from five cases. We discuss how procurement capabilities and evaluation can act as critical drivers for moving from a substantive to a procedural approach to CPP.
‘The Husband, For Whom She Endures All This’: Dutch Men in Childbirth, 1900–1940
Authors: Huistra Hieke 
Published: January 2024

Summary
I argue that in the early twentieth-century Netherlands, fathers regularly attended the birth of their children, and that this attendance was generally accepted or even encouraged by doctors. My findings contrast with existing historiography on the Anglo-Saxon countries, where, at the time, fathers were usually not present at births. I explain this difference between the Netherlands and the Anglo-Saxon countries through the ideal of the harmonious family that permeated Dutch society at the time. I show how birth was seen as a family event, in which the father should be emotionally involved. Men had to manage this emotional involvement carefully: they had to display emotions without losing control of these emotions. My findings show that we need to study doctor-led births in order to fully understand the slow rise of hospital births in the Netherlands.
Robotics-Driven Manufacturing of Cartilaginous Microtissues for Skeletal Tissue Engineering Applications
Authors: Decoene Isaak , Nasello Gabriele , Madeiro de Costa Rodrigo Furtado , Nilsson Hall Gabriella , Pastore Angela , Van Hoven Inge , Ribeiro Viseu Samuel , Verfaillie Catherine , Geris Liesbet , Luyten Frank P , Papantoniou Ioannis 
Published: January 2024

Abstract
Automated technologies are attractive for enhancing the robust manufacturing of tissue-engineered products for clinical translation. In this work, we present an automation strategy using a robotics platform for media changes, and imaging of cartilaginous microtissues cultured in static microwell platforms. We use an automated image analysis pipeline to extract microtissue displacements and morphological features as noninvasive quality attributes. As a result, empty microwells were identified with a 96% accuracy, and dice coefficient of 0.84 for segmentation. Design of experiment are used for the optimization of liquid handling parameters to minimize empty microwells during long-term differentiation protocols. We found no significant effect of aspiration or dispension speeds at and beyond manual speed. Instead, repeated media changes and time in culture were the driving force or microtissue displacements. As the ovine model is the preclinical model of choice for large skeletal defects, we used ovine periosteum-derived cells to form cartilage-intermediate microtissues. Increased expression of COL2A1 confirms chondrogenic differentiation and RUNX2 shows no osteogenic specification. Histological analysis shows an increased secretion of cartilaginous extracellular matrix and glycosaminoglycans in larger microtissues. Furthermore, microtissue-based implants are capable of forming mineralized tissues and bone after 4 weeks of ectopic implantation in nude mice. We demonstrate the development of an integrated bioprocess for culturing and manipulation of cartilaginous microtissues and anticipate the progressive substitution of manual operations with automated solutions for the manufacturing of microtissue-based living implants.