bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oil Production Rate Forecasting by SA-LSTM Model in Tight Reservoirs
Authors: He Denghui , Qu Yaguang , Sheng Guanglong , Wang Bin , Yan Xu , Tao Zhen , Lei Meng 
Published: January 2024

Abstract
The accurate forecasting of oil field production rate is a crucial indicator for each oil field’s successful development, but due to the complicated reservoir conditions and unknown underground environment, the high accuracy of production rate forecasting is a popular challenge. To find a low time consumption and high accuracy method for forecasting production rate, the current paper proposes a hybrid model, Simulated Annealing Long Short-Term Memory network (SA-LSTM), based on the daily oil production rate of tight reservoirs with the in situ data of injection and production rates in fractures. Furthermore, forecasting results are compared with the numerical simulation model output. The LSTM can effectively learn time-sequence problems, while SA can optimize the hyperparameters (learning rate, batch size, and decay rate) in LSTM to achieve higher accuracy. By conducting the optimized hyperparameters into the LSTM model, the daily oil production rate can be forecasted well. After training and predicting on existing production data, three different methods were used to forecast daily oil production for the next 300 days. The results were then validated using numerical simulations to compare the forecasting of LSTM and SA-LSTM. The results show that SA-LSTM can more efficiently and accurately predict daily oil production. The fitting accuracies of the three methods are as follows: numerical reservoir simulation (96.2%), LSTM (98.1%), and SA-LSTM (98.7%). The effectiveness of SA-LSTM in production rate is particularly outstanding. Using the same SA-LSTM model, we input the daily oil production data of twenty oil wells in the same block and make production prediction, and the effect is remarkable.
The influence of food-based enrichment on the behaviour of captive red pandas Ailurus fulgens fulgens
Authors: Khan Aamer Sohel 
Published: January 2024

Abstract

Developing simple and innovative ways to provide feed to captive animals, especially those kept for captive breeding programs is essential because food-based enrichment has a beneficial effect on animal welfare. The red panda is a threatened species and needs support in developing a successful captive breeding program. Indian captive population of red pandas exhibit stereotypic behaviour to some extent (Khan et al., 2022) which could interfere with species biology and hinder captive breeding success. Therefore to combat stress zoos must design effective enrichments. Food-based enrichments are ideal to maintain animal welfare. I studied the effect of feed dispersal on the behaviour of captive red pandas in India. This study analysed whether pacing and aggressive behaviour were reduced, and foraging behaviour increased, when food was spatially distributed around the enclosure (mimicking the panda’s natural habitat) compared to food served on a common platform. Results showed that dispersing the food (known as food-based enrichment) increased the level of behavioural diversity by 1.6 times and foraging by 3.6 times. Similarly, pacing decreased by 5.8 times and aggression by almost three times in the subjects. Individual analysis suggests that behavioural diversity in the male doubled when food was dispersed around the enclosure. This suggests that spatially distributing bamboo stimulates foraging behaviour and limits stereotypical behaviour, such as pacing, in captive red pandas. This study showed that planning simple and innovative food-based enrichments in captivity supports natural behaviours and reduces abnormal behaviours ultimately supporting species conservation.
SUDO: a framework for evaluating clinical artificial intelligence systems without ground-truth annotations
Authors: Kiyasseh Dani , Cohen Aaron , Jiang Chengsheng , Altieri Nicholas 
Published: January 2024

Abstract
A clinical artificial intelligence (AI) system is often validated on a held-out set of data which it has not been exposed to before (e.g., data from a different hospital with a distinct electronic health record system). This evaluation process is meant to mimic the deployment of an AI system on data in the wild; those which are currently unseen by the system yet are expected to be encountered in a clinical setting. However, when data in the wild differ from the held-out set of data, a phenomenon referred to as distribution shift, and lack ground-truth annotations, it becomes unclear the extent to which AI-based findings can be trusted on data in the wild. Here, we introduce SUDO, a framework for evaluating AI systems without ground-truth annotations. SUDO assigns temporary labels to data points in the wild and directly uses them to train distinct models, with the highest performing model indicative of the most likely label. Through experiments with AI systems developed for dermatology images, histopathology patches, and clinical reports, we show that SUDO can be a reliable proxy for model performance and thus identify unreliable predictions. We also demonstrate that SUDO informs the selection of models and allows for the previously out-of-reach assessment of algorithmic bias for data in the wild without ground-truth annotations. The ability to triage unreliable predictions for further inspection and assess the algorithmic bias of AI systems can improve the integrity of research findings and contribute to the deployment of ethical AI systems in medicine.
A role for the thalamus in danger discrimination during sleep
Authors: Adamantidis Antoine , Boccalaro Ida Luisa , Aime Mattia , Aellen Florence , Rusterholz Thomas , Borsa Micaela , Bozic Ivan , Sattin Andrea , Fellin Tommaso , Herrera Carolina Gutierrez , Tzovara Athina 
Published: January 2024

Abstract
Sleep is associated with a sensory disconnection from the environment despite a high vulnerability to danger and predation. Yet, sensory stimuli-evoked responses persist in the brain of flies1, rodents2,3, primates4,5, and humans6,7 during sleep. Whether discrimination between sensory stimuli occurs in the mammalian brain during sleep remains unclear. Here, we showed that neutral auditory stimuli evoked electrical responses propagate in parallel auditory and non-auditory pathway, some of which awaken sleeping mice. We used a convolutional neural network and identified neural activities of centro-medial thalamic (CMT) neurons as the most discriminant hub for auditory-evoked sleep-to-wake transitions among all recorded structures. Importantly, we found that prior associative learning of danger (conditioned stimulus, CS+) and neutral (CS-) auditory cues resulted in increased awakening events upon CS+ exposure during NREM, but not REM, sleep. These sleep-to-wake transitions were blocked by optogenetic silencing of CMT neurons during CS exposure in sleeping mice. Altogether, these results suggest a central role of the CMT neurons in the residual processing of behaviorally-relevant information in the sleeping brain.
Three cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment
Authors: Cunningham Janet , Gallwitz Maike , Lindqvist Isa , Mulder Jan , Rasmusson Annica , Larsson Anders , Husén Evelina , Borin Jesper , Spek Peter van der , Sabbagh Nour , Widgren Anna , Bergquist Jonas , Cervenka Simon , Burman Joachim 
Published: January 2024

Abstract

Obsessive compulsive disorder (OCD) is a debilitating condition affecting about 2% of the population where half of patients do not respond to standard treatment. The emerging concept of an autoimmune OCD subgroup is grounded on findings that suggest immunological aetiology.
We here present the longitudinal clinical course for three severely ill, functionally impaired complex cases with chronic treatment-resistant OCD. In all three cases, off-label treatment with rituximab was followed by clear and sustained gains regarding symptom burden and function over several years. The clinical phenotypes and clinical red flags are described in detail. Antibodies targeting mouse brain tissue were detected in cerebral spinal fluid for all three cases. We report exploratory analyses of immunological markers and proteomics and findings include elevated levels of sCD27 and markers indicative for complement pathway activation in CSF when compared to controls.
Multidisciplinary collaboration, advanced clinical investigations and rituximab treatment are feasible in a psychiatric setting. The case histories provide a proof of principle for the newly proposed criteria for autoimmune OCD. The findings suggest that clinical red flags and biological measures may predict rituximab response in chronic treatment-resistant OCD. The report provides orientation that may inform the hypotheses and design of future treatment trials.
The CRHR1→PN→PVI Pathway in Medial Prefrontal Cortex Mediates Early-life Stress-induced Cognitive Deficits in Adolescent Mice
Authors: Li Jitao , Ma Yu-Nu , Yang Chao-Juan , Zhang Chen-Chen , Sun Ya-Xin , Liu Xiao , Li Xue-Xin , Wang Han , Wang Ting , Wang Xiao-Dong , Su Yun-Ai , Zhang Chen , Si Tian-mei 
Published: January 2024

Abstract

Cognitive impairment, one core symptom of psychiatric disorders, is frequently observed in adolescents exposed to early-life stress (ES). However, the underlying neural mechanisms are unclear and the therapeutic efficacy is limited. Targeting at parvalbumin-expressing interneurons (PVIs) in the medial prefrontal cortex (mPFC), we report that mPFC PVI activity was reduced by ES and causally mediated ES-induced cognitive deficits in adolescent mice through chemogenetic or optogenetic experiments. We then demonstrate that ES reduced the excitatory inputs onto PVIs and pyramidal neuron (PN) activity and that ES negative effects were reversed by the knockout of corticotropin-releasing hormone receptor 1 (CRHR1, mainly expressed in PNs) in mouse mPFC, supporting the prefrontal CRHR1→PN→PVI pathway in mediating ES-induced cognitive deficits. Finally, antalarmin (a CRHR1 antagonist) treatment and environmental enrichment successfully restored PVI activity and cognitive deficits induced by ES. These findings highlight the critical role of PVIs in mediating and preventing ES-induced cognitive deficits in adolescent mice.
effect of online problem solving counseling on the sexual anxiety and intimacy of women with recurrent pregnancy loss: A Clinical Trial
Authors: Bokaie Mahshid , Mohammadkhani Shahla , Ghasemi Nasrin , Sorkhani Tayebeh Mokhtari 
Published: January 2024

Abstract
Background: Recurrent pregnancy loss creates complex reproductive conditions among women globally and in Iran affects many psychological consequences on all aspects of women's lives. Short-term problem solving therapy is one of the sexual health approaches.
Objective: This study was designed to investigate the effect of online problem solving counseling on the sexual anxiety and intimacy of women with RPL.
Materials & Methods:In this Parallel clinical trial, with the control group, the research population consists of women with recurrent pregnancy loss with a recorded file in abortion Center in Yazd. The eligible participants were assigned into two groups including control and intervention, using random allocation software. Participants in the intervention group were given online counseling through a social network with a problem solving approach. Eight weekly sessions were held each lasting 90 min. The control group received an educational file to improve sexual anxiety and intimacy. All participants in two groups completed the questionnaires before, after, and 1 month after the study. Data were analyzed with SPSS16 using descriptive and inferential statistics(P<0.05).
Results: The mean score of sexual anxiety at baseline was 62.8±10.71 in the online group and 62.00±6.43 in the control group (P=0.706). The mean score of sexual anxiety in the eighth and twelfth weeks was significantly less than the online group (53.17±7.13 in the online group and 61.34±6.13 in the control group), (49.74±7.09 in the online group and 61.25±5.96 in the control group). The mean score of sexual intimacy in the baseline was 28.68 ± 2.75 in the online group and 28.31 ± 2.77 in the control group (P=0.576). The mean score of sexual intimacy in the eighth and twelfth weeks was significantly higher in the online group (32.05±2.22 in the online group and 28.31±2.6 in the control group), (32.25±2.35 in the online group and 29.31±2.59 in the control group), (p<0.001).
conclusion: Counseling with problem solving approach in women with RPL improved sexual anxiety and intimacy. hence, this method is recommended as a non-drug and cost-effective method in the form of community-based care.
Trial Registration: This research has been registered in Iran's clinical trial center with code IRCT20220620055229N1 in 14/02/2023.
Urban mobile robot routing using fast search random tree method (RRT) in obstacle environments
Authors: jalalnezhad mostafa , Hsieh Hsin-Yin , Chen Kuan-Hung , Shieh Chich-Jen , Askar Shavan 
Published: January 2024

Abstract

In this thesis, the objective of path planning and control systems for robot is multifactorial. The method used for navigation algorithms based on is closed-loop random trees with quick search or CL-RRT. In this algorithm, each robot will grow a tree from its current location to the target or zone target is developed. The main advantage of this method is the ability to function in complex environments. For use this method, it is necessary that the CL-RRT algorithm for robot navigation online, be extended. In online mode, the robot does not have any information about the environment and through its sensors, which detect the environment and the ability to function in environments with obstacles dynamic and could face a new obstacle or the possibility of an obstacle's dynamic (the other a robot) to change its direction during motion. Performance of the design path used with design the controller for robot in an environment with various obstacles are evaluated and then this design is for a group of robots used. To coordinate among agents and to ensure that there is no conflict between them there is strategy based on, priority assignment and LOS method. The strategy used in a way that ensures that the collision between agents does not happen and benefits of the design methods path used to keep. As a result of this strategy can be divided into two parts, the first part of the prioritization robots and the second part of the strategy, no conflict robot is in motion. In this thesis the problem of forming a group of robots has been investigated. In other words, the agents move in the number of agents must be a specific form. The agents according to a number try to set form (originally defined) to its motion to follow, also when faced with obstacles or other agents of its priorities is no conflict with obstacles or other factors and this moment it is possible to change the shape of their,if this will happen again the situation changes be considered form to make its motion.
The effects of Stim1 and Orai1 expression levels on lymph node metastases and prognosis in patients with triple negative breast cancer
Authors: Yang Qiu-hui , Yang Hong-jian , Fu Ye-qin , Mo Wen-ju , Wang Chen , Mao Jie-fei , Zhang Xi-ping 
Published: January 2024

Abstract

Objective: Calcium signaling pathways are closely related to breast cancer, including Calcium ions (Ca2+) metabolic disorders associated with cell proliferation and migration of triple-negative breast cancer (TNBC). The key proteins of store-operated Ca2+ entry (SOCE), Stromal interaction molecule 1 (Stim1) and calcium release-activated calcium channel protein1(Orai1), play critical roles in the development of TNBC.
Method: Fifty cases of TNBC patients who had treatment in our hospital between January 2011 and January 2016 were included in the study, including no lymph node (LN) metastasis(N=20), 1-3 LNs metastasis(N=20) and ≥4 LNs metastasis(N=10). The para-cancerous tissues of TNBC patients and the plasma of healthy patients (N=20) were used as control groups for tumor tissue and plasma samples of TNBC patients, respectively. Real-time reverse transcription polymerase chain reaction (RT-qPCR) and immunohistochemical (IHC) were used to detect Stim1, Orai1 in the aforementioned tissue and plasma samples, respectively. Meantime, we used the Kaplan Meier (K-M) method to analyze the relationship between the expression levels of Stim1 and Orai1 and the prognosis of TNBC patients. Finally, the expression of SOCE and its key proteins (Stim1 and Orai1) in TNBC patients was analyzed using the TCGA database.
Main results: In TNBC patients, the expression of Stim1 and Orai1 were higher than in the control group (P>0.05). Besides, TNBC patients without LN metastases had higher Orai1 gene expression levels than the group with LN metastasis (P<0.05). The prognosis of TNBC patients is worse when the Orai1 expression is lower (P>0.05). Furthermore, TNBC patients with a tumor diameter≥5cm have a higher degree of axillary LN metastasis and poorer prognosis compared to patients with a diameter＜5cm. On the contrary, bioinformatics analysis showed that the key protein Stim1 of SOCE was downregulated in TNBC patients and negatively correlated with the degree of lymph node metastasis, which is a protective factor in TNBC patients.
Conclusion: Orai1 is expected to be tumor markers in the field of TNBC. In addition, the Orai1 expression level and tumor diameter could be used to predict the TNBC axillary LN metastatic status and prognostic level. The relationship between Stim1 and the degree of TNBC lymph node metastasis needs further research.
Effect of perioperative blood transfusion on complications following emergency non-trauma laparotomy in Mulago hospital: A prospective cohort study.
Authors: Egbe Flavius Ebaisem , Mbiine Ronald , Okello Michael , Iranya Richard Newton , Okeny Paul 
Published: January 2024

Abstract
Background: Blood transfusion may be required in the management of patients undergoing emergency non-trauma laparotomy. However, several retrospective cohort studies involving patients undergoing laparotomy for benign and malignant indications have identified blood transfusion as a significant predictor of postoperative infections and mortality. Still, no study has explored such an association in our setting. We aimed to determine the effect of perioperative blood transfusion on the 30-day risk of surgical site infections and mortality among patients undergoing emergency non-trauma laparotomy in a large urban tertiary hospital in a low-resource setting.
Methods: In this prospective cohort study, we recruited 160 adult patients admitted to the general surgery wards 48 hours after emergency non-trauma laparotomy. We grouped them based on transfusion exposure and non-exposure. Independent variables, including perioperative blood transfusion and confounders, were recorded on entry, while dependent variables, including the presence or absence of surgical site infection and mortality, were obtained over a 30-day follow-up period. Data were analysed using EPI INFO version 7, SPSS version 29 & Stata version 14.
Results: All 160 participants recruited, 28 (17.5%) transfused (exposed) and 132 (82.5%) not transfused (non-exposed), were included in the final analysis. Transfusion exposure (RR, 7.81; 95% CI, 2.58 – 23.63; p=0.0003) and preoperative leucocytosis/leucopoenia (RR, 2.19; 95% CI, 1.04 – 4.65; p=0.040) were identified as independent risk factors for SSI after multivariate logistic regression analysis adjusted for confounders including preoperative anaemia, young-to-middle-aged adults, cloudy/purulent/feculent exudate, gut perforation diagnosis, female sex, and registrar-led surgical team. Furthermore, transfusion exposure (HR, 3.36; 95% CI, 1.11 – 10.25; p=0.033) and old age (HR, 5.50; 95% CI, 1.67 – 18.11; p=0.005) were identified as independent risk factors for 30-day mortality after multivariate Cox regression analysis adjusted for confounders including high ASA score, immunodeficiency, cloudy/purulent/feculent exudate, bowel obstruction and high-risk procedure for bowel leak.
Conclusion: Among patients undergoing emergency non-trauma laparotomy, perioperative blood transfusion compared to no perioperative blood transfusion increased the risk of 30-day SSI by 7.81 and the 30-day mortality risk by 3.36. A restrictive transfusion strategy and a more extensive multicentre prospective cohort study are recommended.
Evaluating Bacterial Population Changes and Ecological Dynamics in Oil-Impacted Soils Using 16S rRNA Amplicon Sequencing
Authors: Rahube Teddie Onkabetse , Selvarajan Ramganesh , Nduna Batendi , Nthaba Bokani , Molwalefhe Loago , Shemang Elisha 
Published: January 2024

Abstract

Improper disposal of used motor oil is a prevalent issue in developing countries, leading to a notable contribution to environmental pollution. This study was conducted using the 16S rRNA targeted metagenomic approach, to assess the changes in bacterial population diversity and abundance at an oil contamination experimental site in Botswana. To demonstrate the impact of used motor oil is on the soil ecosystem, soil samples collected at different depths before and after treatment with used motor oil were subjected to total community DNA extraction and Illumina sequencing. The taxonomic bacterial composition data revealed statistically significant differences among the treatments and controls. A notable shift from Gram-negative to Gram-positive bacterial populations was observed following treatment with used motor oil. Prevotella and Aerococcus were among the few genera within the enriched Gram-positive bacteria that could be directly linked to biodegradation of the polycyclic aromatic hydrocarbons associated with oil contamination. Agricultural and biotechnologically important, plant-associated bacterial genera; Methylobacterium-methylorumbrum, Bradyrhizobium, and, Phyllobacterium significantly declined in relative abundance, thus demonstrating the negative impact of oil contamination. The results from this study, improves our understanding of the roles of indigenous soil bacteria, and can help in guiding future strategies for the sustainable management of contaminated soils globally in countries with similar climatic and ecological conditions.