bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of a new high‐dose regimen of panobinostat, gemcitabine, busulfan, and melphalan for 1st or 2nd salvage ASCT for refractory/relapsed or high‐risk myeloma: Matched‐pair comparisons with concurrent control cohorts
Authors: Nieto Yago , Yang Zixi , Valdez Benigno C. , Kundu Suprateek , Bashir Qaiser , Ramdial Jeremy , Srour Samer , Qazilbash Muzaffar 
Published: December 2023

AbstractImprovement of autologous stem‐cell transplantation (ASCT) for myeloma is needed. Building on our prior work, we prospectively evaluated panobinostat and gemcitabine/busulfan/melphalan (GemBuMel) with ASCT in this population. Patients aged 18–65 years with relapsed/refractory or high‐risk myeloma and adequate end‐organ function were eligible. Treatment included panobinostat (20 mg/day, days −9 to −2) and GemBuMel (days −8 to −2). Patients were enrolled in 1st (ASCT‐1) or 2nd ASCT (ASCT‐2) cohorts. We compared their outcomes with all our other concurrent ASCT patients who met eligibility criteria but received melphalan or BuMel off study, matched for age, prior therapy lines, high‐risk cytogenetics, and response at ASCT. We enrolled 80 patients, 48 and 32 in the ASCT‐1 and ASCT‐2 cohorts, respectively; in these two cohorts, high‐risk cytogenetics were noted in 33 and 15 patients, respectively; unresponsive disease in 12 and 11 patients, respectively, after a median of 2 and 3 therapy lines, respectively. Transplant‐related mortality (TRM) occurred in two ASCT‐2 patients. One‐year PFS rates were 69% (ASCT‐1) and 72% (ASCT‐2); 1‐year OS rates were 79% (ASCT‐1) and 84% (ASCT‐2). Minimal residual disease negativity improved after ASCT‐1 (8.5%–23%, p < .0001) and ASCT‐2 (34%–55%, p = .02), which correlated with improved outcomes. Trial patients and controls (N = 371) had similar TRM and post‐ASCT maintenance. Trial patients had better PFS after either a 1st (p = .02) or a 2nd ASCT (p = .04) than matched‐paired control patients. In conclusion, panobinostat/GemBuMel is effective for relapsed/refractory or high‐risk myeloma patients, with better PFS than concurrent matched controls receiving melphalan or BuMel.
Regioselective Synthesis of Isoxazoles from Propargylic Alcohols via In‐situ‐formed α‐Iodo Enones/Enals
Authors: Yang. Hong , Chen Jiaming , He Shuai , Wu Lijuan , Zhou Min , Cai Jiaming , Yang Wenfeng , Wang Zhuwen , Wang Jianlun , Wang Xiaoyang , Yin Yan 
Published: December 2023

AbstractA regioselective synthesis of isoxazoles with propargyl alcohols, N‐iodosuccinimide (NIS), and N‐tert‐butyl hydroxylamine hydrochloride (t‐BuNHOH•HCl) as the reaction substrates is reported. Reaction scope investigations indicated that primary and secondary propargyl alcohols underwent this transformation smoothly to afford 5‐, 3‐, and 3,5‐substituted isoxazoles in moderate to good yields. The reaction most likely involves an electrophilic‐intercepted Meyer‐Schuster rearrangement of the propargyl alcohol, followed by intermolecular cyclocondensation of N‐tert‐butyl hydroxylamine and in‐situ‐formed α‐iodo enones/enals. This one‐pot method is regioselective and easy to perform, making it a valuable method for the construction of isoxazoles. Finally, its application was explored through the synthesis of valdecoxib.
Selenium‐Based Catalytic Scavengers for Concurrent Scavenging of H2S and Reactive Oxygen Species
Authors: Ni Xiang , Marutani Eizo , Shieh Meg , Lam Yannie , Ichinose Fumito , Xian Ming 
Published: December 2023

AbstractHydrogen sulfide (H2S) is an endogenous gasotransmitter that plays important roles in redox signaling. H2S overproduction has been linked to a variety of disease states and therefore, H2S‐depleting agents, such as scavengers, are needed to understand the significance of H2S‐based therapy. It is known that elevated H2S can induce oxidative stress with elevated reactive oxygen species (ROS) formation, such as in H2S acute intoxication. We explored the possibility of developing catalytic scavengers to simultaneously remove H2S and ROS. Herein, we studied a series of selenium‐based molecules as catalytic H2S/H2O2 scavengers. Inspired by the high reactivity of selenoxide compounds towards H2S, 14 diselenide/monoselenide compounds were tested. Several promising candidates such as S6 were identified. Their activities in buffers, as well as in plasma‐ and cell lysate‐containing solutions were evaluated. We also studied the reaction mechanism of this scavenging process. Finally, the combination of the diselenide catalyst and photosensitizers was used to achieve light‐induced H2S removal. These Se‐based scavengers can be useful tools for understanding H2S/ROS regulations.
Phthalimide‐tethered isatins as novel poly(ADP‐ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations
Authors: El Hassab Mahmoud A. , El‐Hafeez Amer Ali Abd , Almahli Hadia , Elsayed Zainab M. , Eldehna Wagdy M. , Hassan Ghaneya S. , Abou‐Seri Sahar M. 
Published: December 2023

AbstractHumanity is currently facing various diseases with significant mortality rates, particularly those associated with malignancies. Numerous enzymes and proteins have been identified as highly promising targets for the treatment of cancer. The poly(ADP‐ribose) polymerases (PARPs) family comprises 17 members which are essential in DNA damage repair, allowing the survival of cancer cells. Unlike other PARP family members, PARP‐1 and, to a lesser extent, PARP‐2 show more than 90% activity in response to DNA damage. PARP‐1 levels were shown to be elevated in various tumor cells, including breast, lung, ovarian, and prostate cancer and melanomas. Accordingly, novel series of phthalimide‐tethered isatins (6a‐n, 10a‐e, and 11a‐e) were synthesized as potential PARP‐1 inhibitors endowed with anticancer activity. All the synthesized molecules were assessed against PARP‐1, where compounds 6f and 10d showed nanomolar activities with IC50 = 15.56 ± 2.85 and 13.65 ± 1.42 nM, respectively. Also, the assessment of the antiproliferative effects of the synthesized isatins was conducted on four cancer cell lines: leukemia (K‐562), liver (HepG2), and breast (MCF‐7 and HCC1937) cancers. Superiorly, compounds 6f and 10d demonstrated submicromolar IC50 values against breast cancer MCF‐7 (IC50 = 0.92 ± 0.18 and 0.67 ± 0.12 µM, respectively) and HCC1937 (IC50 = 0.88 ± 0.52 and 0.53 ± 0.11 µM, respectively) cell lines. In addition, compounds 6f and 10d induced arrest in the G2/M phase of the cell cycle as compared to untreated cells. Finally, in silico studies, including docking and molecular dynamic simulations, were performed to justify the biological results.
Probing the p‐type Chemiresistive Response of NiFe2O4 Nanoparticles for Potential Utilization as Ethanol Sensor
Authors: Bhagat B. , Gupta Santosh K. , Mandal D. , Gor Abhishek A. , Bandyopadhyay R. , Mukherjee K. 
Published: December 2023

AbstractDetection of gas molecules and volatile organic compounds (VOCs) using efficient, low cost sensors has fetched significant attention in environmental monitoring, safety measures and medical diagnosis. In the present work, nickel ferrite (NFO) nanoparticles are explored as p‐type semiconducting metal oxide (SMO) sensor for detection of five different organic vapors namely methanol, ethanol, n‐propanol, iso‐propanol and acetone which often cause severe damage to human body under prolonged exposure. The sensing studies in presence of the aforementioned five vapors are carried out by varying the sensor operating temperature (225–300 °C) and vapor concentrations (10–1000 ppm). Developed NFO sensor demonstrated best performance in terms of sensing (~10 ppm), response time (<10 s), excellent repeatability and selectivity towards ethanol among all other considered gas species. The repeatability of the sensor response is verified and the underlying reasons for the variation in the response of NFO sensor due to the change of operating temperature, analyte type and concentrations has been discussed. The synthesis of NFO through auto combustion method and study on their formation behaviour, oxygen vacancy evolution, band gap calculation, crystalline nature as well as microstructural features provides here the comprehensive information about the potential application of NFO nanoparticles as gas sensor.
Investigating the link between biological dehumanization and indirect aggression
Authors: Valtorta Roberta Rosa , Baldissarri Cristina , Volpato Chiara 
Published: December 2023

AbstractThe present research aims at expanding the literature on biologization (i.e., a form of dehumanization in which others are perceived as contagious entities) by providing the first empirical evidence of the link between this sociopsychological process and indirect aggression (i.e., behaviours intended to harm someone in a roundabout manner, such as excluding them from a group or society). We first identified the most dehumanized social groups in Italy. Then, by using cluster analysis, we demonstrated that biologized social groups (i.e., drug addicts, homeless people, prostitutes, and sick people) tend especially to be victims of indirect rather than direct aggression tendencies (i.e., intentions against individuals or groups to cause damage through face‐to‐face confrontation). Furthermore, we found that social groups associated with disease‐related metaphors are more likely to be victims of indirect aggression than social groups perceived as animal‐like (i.e., immigrants, prisoners, and Roma). These findings enrich our understanding of biological dehumanization and enhance the so far scarce literature on the topic.
Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases
Authors: Ramanathan Kumaresan , Fekadie Minale , Padmanabhan Giri , Gulilat Henok 
Published: December 2023

AbstractLong noncoding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury, chronic kidney disease, and renal cell carcinoma. Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, and biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment.
Molecular characterization, rheological properties, and prebiotic properties of arabinoxylans from waxy and sweet corn cobs
Authors: Pang Jinxin , Zhang Yi , Song Xin , Tong Xiaoyang , Wu Songheng , Hu Yingxiong , Zhong Yaoguang , Qiao Yongjin 
Published: December 2023

AbstractBackground and ObjectivesArabinoxylan (AX) has diverse physicochemical properties and biological activities, related to the structural differences caused by various sources and extraction methods. We study the differences in molecular characterization, rheological properties, and prebiotic properties in waxy and sweet corn cobs AX, and water‐extractable and water‐unextractable arabinoxylan (EAX, UAX).FindingsThe arabinose to xylose ratios (Ara/Xyl) of waxy corn cobs AX were lower than that of sweet corn cobs AX. Also, the viscosity of all samples increased with increasing concentration and decreasing temperature. In the vitro probiotic fermentation, waxy corn cobs AX was stronger in promoting the growth of probiotics than AX from sweet corn cobs. Probiotics in the AX group were predominantly acetic acid and butyric acid producers, and the waxy corn cobs AX group produced more short‐chain fatty acids than the sweet corn cobs AX group, resulting in a lower pH in the waxy corn cobs AX group.ConclusionsEAX and UAX also showed significant variations in molecular characterization, viscosity, and prebiotic properties. Waxy corn cobs AX had stronger prebiotic activity than sweet corn cobs AX.Significance and NoveltyThis experiment provides a theoretical and experimental basis for studying the prebiotic properties of AX, which could guide the application of fresh corn cobs‐derived AX.
Counselor educators’ gatekeeping experiences during dissertation
Authors: DeCino Daniel A. , Waalkes Phillip L. , Jorgensen Maribeth F. , Boughn Alison 
Published: December 2023

AbstractLittle is known about counselor educators’ experiences of gatekeeping doctoral students. Using an interpretative phenomenological approach, we examined counselor educators’ experiences of gatekeeping doctoral students during the dissertation. Themes included (a) interventions, (b) prior student gatekeeping interactions, and (c) recommendations for gatekeeping during the dissertation. Implications and suggestions for research are provided.
Electroplated Electrodes for Continuous and Mass‐Efficient Electrochemical Hydrogenation
Authors: Wolf Jonas , Pellumbi Kevinjeorjios , Haridas Sarankumar , Kull Tobias , Kleinhaus Julian T. , Wickert Leon , Apfel Ulf‐Peter , Siegmund Daniel 
Published: December 2023

AbstractElectrocatalytic hydrogenations (ECH) enable the reduction of organic substrates upon usage of electric current and present a sustainable alternative to conventional processes if green electricity is used. Opposed to most current protocols for electrode preparation, this work presents a one‐step binder‐ and additive‐free production of silver‐ and copper‐electroplated electrodes. Controlled adjustment of the preparation parameters allows for the tuning of catalyst morphology and its electrochemical properties. Upon optimization of the deposition protocol and carbon support, high faradaic efficiencies of 93 % for the ECH of the Vitamin A‐ and E‐synthon 2‐methyl‐3‐butyn‐2‐ol (MBY) are achieved that can be maintained at current densities of 240 mA cm−2 and minimal catalyst loadings of 0.2 mg cm−2, corresponding to an unmatched production rate of 1.47 kgMBE gcat−1 h−1. For a continuous hydrogenation process, the protocol can be directly transferred into a single‐pass operation mode giving a production rate of 1.38 kgMBE gcat−1 h−1. Subsequently, the substrate spectrum was extended to a total of 17 different C−C−, C−O− and N−O−unsaturated compounds revealing the general applicability of the reported process. Our results lay an important groundwork for the development of electrochemical reactors and electrodes able to directly compete with the palladium‐based thermocatalytic state of the art.
Comparative analysis of cysteine proteases reveals gene family evolution of the group 1 allergens in astigmatic mites
Authors: Shi Ling , Xiong Qing , Ao Fu Kiu , Wan Tsz Yau , Xiao Xiaojun , Liu Xiaoyu , Sun Baoqing , Tungtrongchitr Anchalee , Leung Ting Fan , Tsui Stephen Kwok Wing 
Published: December 2023

AbstractBackgroundAstigmatic mites contain potent allergens that can trigger IgE‐mediated immune responses, leading to allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. In house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae, group 1 allergens (Der p 1 and Der f 1), characterized as papain‐like cysteine proteases, have been defined as the major allergens that have high prevalence and potency. Previous studies of mite group 1 allergens mainly focused on identification, comparison of sequence and structure, as well as the investigation of cross‐reactivity. To achieve a comprehensive view of mite group 1 allergens, we performed a comparative genomic analysis of all the cysteine proteases in six astigmatic mite species to elucidate the evolutionary relationships of group 1 allergens.MethodsBased on the high‐quality and annotated genomes, all the cysteine proteases in six astigmatic mite species were identified by sequence homology search. The phylogenetic relationships, gene synteny and expression levels were revealed by bioinformatic tools. The allergenicity of recombinant cysteine proteases was evaluated by enzyme‐linked immunosorbent assay.ResultsTandem duplication was revealed as the major feature of cysteine protease gene evolution in astigmatic mites. The high IgE‐binding capacity and the significant expression level of the cysteine protease DP_007902.01 suggested its potential as a novel group 1 allergen of D. pteronyssinus. In addition, gene decay events were identified in the skin‐burrowing parasitic mite Sarcoptes scabiei.ConclusionThis comprehensive analysis provided insights into the evolution of cysteine proteases, as well as the component‐resolved diagnosis of mite allergies.
The cumulative burden of self‐reported, clinically relevant outcomes in long‐term childhood cancer survivors and implications for survivorship care: A DCCSS LATER study
Authors: Streefkerk Nina , Teepen Jop C. , Feijen Elizabeth A. M. , Jóźwiak Katarzyna , van der Pal Helena J. H. , Ronckers Cecile M. , De Vries Andrica C. H. , Van der Heiden‐van Der Loo Margriet , Hollema Nynke , van den Berg Marleen , Loonen Jacqueline , Grootenhuis Martha A. , Bresters Dorine , Versluys A. Brigitta , van Dulmen‐den Broeder Eline , van den Heuvel‐Eibrink Marry M. , van Leeuwen Flora E. , Neggers Sebastian J. C. M. M. , Van Santen Hanneke M. , Hawkins Mike , Hauptmann Michael , Yoneoka Daisuke , Korevaar Joke C. , Tissing Wim J. E. , Kremer Leontien C. M. ,   DCCSS LATER Study Group
Published: December 2023

AbstractBackgroundThe aim of this study is to evaluate how cumulative burden of clinically relevant, self‐reported outcomes in childhood cancer survivors (CCSs) compares to a sibling control group and to explore how the burden corresponds to levels of care proposed by existing risk stratifications.MethodsThe authors invited 5925 5‐year survivors from the Dutch Childhood Cancer Survivor Study (DCCSS LATER) cohort and their 1066 siblings to complete a questionnaire on health outcomes. Health outcomes were validated by self‐reported medication use or medical record review. Missing data on clinically relevant outcomes in CCSs for whom no questionnaire data were available were imputed with predictive mean matching. We calculated the mean cumulative count (MCC) for clinically relevant outcomes. Furthermore, we calculated 30‐year MCC for groups of CCSs based on primary cancer diagnosis and treatment, ranked 30‐year MCC, and compared the ranking to levels of care according to existing risk stratifications.ResultsAt median 18.5 years after 5‐year survival, 46% of CCSs had at least one clinically relevant outcome. CCSs experienced 2.8 times more health conditions than siblings (30‐year MCC = 0.79; 95% confidence interval [CI], 0.74–0.85 vs. 30‐year MCC = 0.29; 95% CI, 0.25–0.34). CCSs’ burden of clinically relevant outcomes consisted mainly of endocrine and vascular conditions and varied by primary cancer type. The ranking of the 30‐year MCC often did not correspond with levels of care in existing risk stratifications.ConclusionsCCSs experience a high cumulative burden of clinically relevant outcomes that was not completely reflected by current risk stratifications. Choices for survivorship care should extend beyond primary tumor and treatment parameters, and should consider also including CCSs’ current morbidity.
Factors influencing parents’ choice of palliative treatment goals for children with relapsed or refractory neuroblastoma: A multi‐site longitudinal survey study
Authors: Kaye Erica C. , Smith Jesse , Zhou Yiwang , Bagatell Rochelle , Baker Justin N. , Cohn Susan L. , Diller Lisa R. , Glade Bender Julia L. , Granger M. Meaghan , Marachelian Araz , Park Julie R. , Rosenberg Abby R. , Shusterman Suzanne , Twist Clare J. , Mack Jennifer W. 
Published: December 2023

AbstractBackgroundMany parents of children with advanced cancer report curative goals and continue intensive therapies that can compound symptoms and suffering. Factors that influence parents to choose palliation as the primary treatment goal are not well understood. The objective of this study was to examine experiences impacting parents’ report of palliative goals adjusted for time. The authors hypothesized that awareness of poor prognosis, recall of oncologists’ prognostic disclosure, intensive treatments, and burdensome symptoms and suffering would influence palliative goal‐setting.MethodsThe authors collected prospective, longitudinal surveys from parents of children with relapsed/refractory neuroblastoma at nine pediatric cancer centers across the United States, beginning at relapse and continuing every 3 months for 18 months or until death. Hypothesized covariates were examined for possible associations with parental report of palliative goals. Generalized linear mixed models were used to evaluate factors associated with parents’ report of palliative goals at different time points.ResultsA total of 96 parents completed surveys. Parents were more likely to report a primary goal of palliation when they recalled communication about prognosis by their child’s oncologist (odds ratio [OR], 52.48; p = .010). Treatment intensity and previous ineffective therapeutic regimens were not associated with parents’ report of palliative goals adjusted for time. A parent who reported new suffering for their child was less likely to report palliative goals (OR, 0.13; p = .008).ConclusionsParents of children with poor prognosis cancer may not report palliative goals spontaneously in the setting of treatment‐related suffering. Prognostic communication, however, does influence palliative goal‐setting. Evidence‐based interventions are needed to encourage timely, person‐centered prognostic disclosure in the setting of advanced pediatric cancer.Plain Language Summary

Many parents of children with poor‐prognosis cancer continue to pursue curative treatments that may worsen symptoms and suffering.
Little is known about which factors influence parents to choose palliative care as their child’s main treatment goal.
To explore this question, we asked parents of children with advanced neuroblastoma across the United States to complete multiple surveys over time.
We found that the intensity of treatment, number of treatments, and suffering from treatment did not influence parents to choose palliative goals.
However, when parents remembered their child’s oncologist talking about prognosis, they were more likely to choose palliative goals of care.
Synthesis and Characterization of Single Crystals of Creatininium Hydrochloride for Third‐Order NLO Applications
Authors: Meeraa S. R. , Parthasarathy M. 
Published: December 2023

AbstractSingle crystals of Creatininium hydrochloride (CTNHCl) are grown by the conventional solution growth method using Millipore water at 32 °C. X‐ray diffraction reveals that it crystallizes in a monoclinic with a space group of P21/n. Solubility studies are performed at different temperatures. Intermolecular interactions involving distinct molecular moieties are also studied by mapping the 3D Hirshfeld surface and its fingerprint plots. Using FT‐IR, spectral analysis is identified. The optical efficiency of the material is studied using UV–vis–NIR and photoluminescence studies. SEM and EDAX analysis are performed for the title compound. Thermal behavior is analyzed, and the material started to melt at 275 °C. Third‐order nonlinear properties of the material like β, n2,
χ(3) values are calculated using the z‐scan technique.