bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wireless Battery‐Free Peripheral Nerve Stimulation Conch for Remote Muscle Activation
Authors: Zhang Mingwang , Yang Guangyou , Long Zhihe , Tang Yong , Li Dongming , Liang Shan , Lin Rui , Yang Zhixin , Bao Han , Xing Lili , Xue Xinyu , Zhan Yang , Xie Yan 
Published: November 2023

AbstractPeripheral nerve stimulators have emerged as a crucial instrument in the realm of neurological disease, capable of modulating nerve activity through precisely targeted electrical stimulation to specific sites within the nervous system. Herein, a new wireless battery‐free peripheral nerve stimulation device for remote muscle activation is developed. The device with conch‐inspired bionic design can be wirelessly powered and controlled by a mobile phone playing audio via the piezoelectric effect. The device consists of two parts: a conch‐like signal‐intensifying piezoelectric resonator for converting acoustic wave into electrostimulation signal; and a pedestal with stimulation electrodes for transmitting the electrostimulation signal to a peripheral nerve. For remote nerve intervention, a programmed audio tone from one mobile phone can be tele‐transmitted from other phones according to the desired stimulation protocols. In‐vivo experiments in stimulating the sciatic nerve in mice showed that the device can activate muscles (e.g., 1 Hz 920 mV for 26 degree of leg movement), and the neuron‐muscle interaction has been confirmed by electromyogram (EMG). The wireless peripheral nerve stimulation conch achieves feasible remote muscle activation without batteries, and can extend the scope of self‐powered techniques for telemedicine and limb/trunk rehabilitation.
Detection of Charge‐Neutral Near‐Equilibrium Processes at Na‐Metal Electrodes by Electrochemical Microcalorimetry
Authors: Karcher Franziska , Uhl Matthias , Geng Tanja , Jacob Timo , Schuster Rolf 
Published: November 2023

AbstractInvestigations on electrochemical kinetics usually rely on the measurement of current or potential as a function of time. Charge‐neutral process steps or side reactions are naturally disguised in the electrical signals and have only indirect impact. However, all processes will contribute to heat evolution. In this work, heat absorption/liberation is measured as a function of time for pulsed Na deposition/dissolution on a Na‐electrode in a 1 m NaPF6/diglyme solution, in addition to the standard electrochemical signals. While potential and current transients both exhibited sharp rectangular shapes, indicating instantaneous electrochemical Na deposition or dissolution on the time scale of the pulse (10 ms), heat absorption or liberation continued up to about 0.5 s after the pulse. Since heat evolution is to large extent reversible, this corresponded to entropy changes in the absence of external electric current flow, pointing to a reversible, charge‐neutral chemical process accompanying Na deposition or dissolution. From the observed entropy changes, it is suggested that upon Na deposition solvated Na+ ions are instantaneously transferred into the outer layers of the solid electrolyte interphase, followed by slow desolvation.
Fixing the leaky physician‐scientist pipeline: Integrated–dedicated research period programs in emergency medicine
Authors: Veverka Mitchell C. , Ryus Caitlin R. , Gerardo Charles J. , Bernstein Steven L. , Limkakeng Alexander T. 
Published: November 2023

AbstractEmergency physicians (EPs) are well positioned to perform medical research. EPs are exposed to a wide range of disease types, medical specialties, and treatment modalities. Furthermore, emergency medicine (EM) serves as the safety net for the U.S. health care system. The diverse exposure provides a vast opportunity for EP to perform many worthwhile research projects. Yet, EM has historically had the lowest amount of funding and a lower number of National Institutes of Health–funded research projects. Many suggest the etiology is a “leaky” educational pipeline with loss of many potential physician‐scientists over the training and development course. Current research training options for the EM physician‐scientist includes MD‐PhD, 4‐year EM residency program and postresidency fellowships. While each has its advantages and disadvantages, we describe an additional educational alternative of EM physician‐scientists, which we have named the integrated–dedicated research period within an EM residency. We describe the features of these programs and preliminary results from the graduates and current trainees.
Preparation of asymmetric tubular Co‐SiC catalytic membrane for synergistic removal of PM2.5, NO, and toluene
Authors: Chen Jiahao , Yin Yongliang , Tan Jiesong , Zeng Yiqing , Low Ze‐Xian , Zhong Zhaoxiang , Xing Weihong 
Published: November 2023

AbstractSiC catalytic membranes exhibit remarkable promise in controlling of dust and atmospheric pollutant emissions. However, their fabrication is limited to small‐scale production, with dimensions up to a disc of 30 mm in diameter. Scaling up the fabrication to tubular SiC catalytic membranes without compromising their application performance remains a challenge due to uncontrollable structural defects during processing. Herein, a tubular Co‐SiC (TCS) catalytic membrane was fabricated through a combination of cold‐isostatic‐pressure molding, spin spray‐coating and acid‐treating processes. The TCS catalytic membrane shows high filtration efficiencies toward industrial‐PM2.5 concentrations. A competitive reaction between NO and toluene was observed on TCS catalytic membrane, and the toluene oxidation is prioritized at low temperatures. In a 52 h stability test, the TCS catalytic membrane achieved PM2.5, NO, and toluene removal efficiencies of 98.92%, 70%, and 100%, respectively. This study lays the foundation for the practical implementation of SiC catalytic membranes in industrial emissions treatment.
Enantioselective Reaction of Diynes and Multiynes for the Synthesis of Axially Chiral Compounds
Authors: Zhu Xin‐Qi , Li Yu‐Chao , Ye Long‐Wu 
Published: November 2023

AbstractDiynes and multiynes have proven to versatile synthons for the synthesis of a range of useful cyclic compounds, especially functionalized complicated polycyclic skeletons comprising carbocycles and heterocycles. Axially chiral compounds, one of the most significant class of compounds featuring axial chirality, are widely existed in natural products and pharmaceuticals as well as chiral ligands and chiral catalysts. Over the past decades, numerous of synthetic protocols have been established for the atroposelective synthesis of axially chiral compounds. However, the catalytic asymmetric atroposelective reaction of diynes and multiynes has been rarely investigated and there is no systematic brief up to now. In this review, we summarize the advances in the attainments of the catalytic asymmetric reaction of diynes and multiynes for the construction of axially chiral compounds, and also propose the remained challenges and opportunities for future breakthroughs in this field.
Construction of C2‐C3 Contiguous Stereogenic Centers in Indoline Derivatives by 1,3‐Dipolar Cycloaddition
Authors: Ito Natsuki , Arai Shigeru , Nishida Atsushi 
Published: November 2023

AbstractWe report a reduction‐condensation‐1,3‐dipolar cycloaddition sequence to create C2‐C3 contiguous stereogenic centers in indoline derivatives. This method includes a one‐pot procedure starting from easily obtainable nitroketones and can be applied to intrarmolecular cycloaddition to give highly functionalized isoxazolidines. Both a length of methylene tether and olefinic substituents strongly affect the cycloaddition mode (exo/endo approach) to give highly stereo‐controlled tri‐ and tetracyclic systems through a single operation. Intermolecular cycloaddition is also applicable to the construction of 3 stereocenters in range of 47–87 % yield.
NHC‐Catalyzed C3‐Acylation of 2‐Oxindoles by Selective Aerobic Oxidation of Aryl Aldehydes
Authors: Muthuvel Karthick , Gandhi Thirumanavelan 
Published: November 2023

AbstractWe here report an effective NHC‐catalyzed acylation of 2‐oxindoles using aldehydes with the aid of aerobic oxidation to prepare 3‐alkylideneoxindoles ‐ a biologically active moiety. This protocol is the first report on the use of oxidized Breslow intermediate for the carbon nucleophile and applies to a wide variety of aryl aldehydes, cyclohexanal, and metallocene‐aldehyde. Lower catalyst loading, milder base, greener oxidant, easily available substrates, and ambient reaction temperature exemplify this as a sustainable methodology.
Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta‐analysis
Authors: Beck Emorie D. , Yoneda Tomiko , James Bryan D. , Bennett David A. , Hassenstab Jason , Katz Mindy J. , Lipton Richard B. , Morris John , Mroczek Daniel K. , Graham Eileen K. 
Published: November 2023

AbstractINTRODUCTIONThe extent to which the Big Five personality traits and subjective well‐being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia‐related neuropathology is unclear.METHODSUsing data from eight independent studies (Ntotal= 44,531; Ndementia= 1703; baseline Mage= 49 to 81 years, 26 to 61% female; Mfollow‐up range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.RESULTSSynthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long‐term dementia diagnosis. There were no consistent associations with neuropathology.DISCUSSIONThis multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy.Highlights
N(+), C(−), E(−), PA(−), and NA(+) were associated with incident diagnosis.
Results were consistent despite self‐report versus clinical diagnosis of dementia.
Psychological factors were not associated with neuropathology at autopsy.
Individuals with higher conscientiousness and no diagnosis had less neuropathology.
High C individuals may withstand neuropathology for longer before death.
Fast Interfacial Carrier Dynamics Modulated by Bidirectional Charge Transport Channels in ZnIn2S4‐based Composite Photoanodes Probed by Scanning Photoelectrochemical Microscopy
Authors: Zhang Shengya , Du Peiyao , Xiao Hui , Wang Ze , Zhang Rongfang , Luo Wei , An Juan , Gao Yuling , Lu BingZhang 
Published: November 2023

AbstractLimited charge separation/transport efficiency remains the primary obstacle of achieving satisfying photoelectrochemical (PEC) water splitting performance. Therefore, it is essential to develop diverse interfacial engineering strategies to mitigate charge recombination. Despite obvious progress having been made, most works only considered a single‐side modulation in either the electrons of conduction band or the holes of valence band in a semiconductor photoanode, leading to a limited PEC performance enhancement. Beyond this conventional thinking, we developed a novel coupling modification strategy to achieve a composite electrode with bidirectional carrier transport for a better charge separation, in which Ti2C3Tx MXene quantum dots (MQDs) and α‐Fe2O3 nanodots (FO) are anchored on the surface of ZnIn2S4 (ZIS) nanoplates, resulting in markedly improved PEC water splitting of pure ZIS photoanode. Systematic studies indicated that the bidirectional charge transfer pathways were stimulated due to MQDs as “electron extractor” and S−O bonds as carriers transport channels, which synergistically favors significantly enhanced charge separation. The enhanced kinetic behavior at the FO/MQDs/ZIS interfaces was systematically and quantitatively evaluated by a series of methods, especially scanning photoelectrochemical microscopy. This work may deepen our understanding of interfacial charge separation, and provide valuable guidance for the rational design and fabrication of high‐performance composite electrodes.
A Nanoinhibitor Targeting cGAS‐STING Pathway to Reverse the Homeostatic Imbalance of Inflammation in Psoriasis
Authors: Zhang Zhibin , Zhou Dongtao , Li Zhun , Luan Xiaowei , Yang Jingjing , Tang Shaochun , Song Yujun 
Published: November 2023

AbstractPsoriasis is a chronic skin inflammation characterized by dysregulated crosstalk between immune cells and keratinocytes. Here we show that the cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) pathway is a key regulator of psoriatic inflammation in a mouse model. Platinum‐doped positively charged carbon dots (Pt‐CDs) were designed to inhibit the cGAS‐STING pathway. By inhibiting the cGAS‐STING pathway with Pt‐CDs, the secretion of proinflammatory cytokines in macrophages was reduced, and the proinflammatory cytokines‐induced breakdown of immunological tolerance and overexpression of chemokines in keratinocytes was restored, which reversed the homeostatic imbalance through breaking these cytokines‐mediated intercellular positive feedback loop. Topical Pt‐CDs treatment exhibited therapeutic effects in imiquimod‐induced psoriasis mice without noticeable toxicity. The reversal of elevated expression of STING, phosphorylated STING, and downstream genes within psoriatic lesions indicates that Pt‐CDs effectively inhibit the cGAS‐STING pathway. This work suggests a promising strategy for psoriasis treatment by targeting the cGAS‐STING pathway with Pt‐CDs nanoinhibitor to restore skin homeostatic balance.
Adverse experiences in early intimate relationships and next‐generation infant–mother attachment: findings from the ATP Generation 3 Study
Authors: Olsson Catherine M. , Greenwood Christopher J. , Letcher Primrose , Tan Evelyn , Opie Jessica E. , Booth Anna , McIntosh Jennifer , Olsson Craig A. 
Published: November 2023

AbstractChronic insecurities that emerge from adverse experiences in early intimate partner relationships in adolescence and emerging adulthood can have profound impacts on mental health and well‐being. Less clear is the extent to which these experiences for parents impact subsequent relationships within and across generations. We examine the extent to which secure, dismissing, pre‐occupied, and fearful intimate partner relationships in adolescence and emerging adulthood, well before becoming a parent, are associated with next‐generation patterns of attachment between mothers and infant offspring. Data were drawn from a nested study of infant–mother attachment (n = 220) within the Australian Temperament Project Generation 3 Study (N = 1167, est. 1983). Intimate partner relationships in adolescence and young adulthood were assessed by self‐report at 23–24 years of age. Over a decade later, infant–mother attachment security was assessed at 12 months post‐partum. Young adult intimate partner relationships defined by high levels of fearful, pre‐occupied, and dismissing attachment styles were reported in 11%, 17%, and 38% of young mothers, respectively. Increases in fear of intimacy in relationships were associated with an increase in the odds, by around 50%, of infant–mother insecure attachments (vs secure; OR = 1.56, 95% CI = 1.07, 2.28) and disorganised attachments (vs organised; OR = 1.49, 95% CI = 1.00, 2.22). A mother's self‐reported history of fear of intimacy within young adult relationships predicts later insecure and disorganised mother–infant attachments. Guidance and greater support for young people navigating their earliest intimate relationships may not only prevent adverse relational experiences at the time but also on becoming a parent. Findings have relevance for family and infant mental health therapies. Translating these findings into supported conversations may help prevent infant–mother attachment difficulties, or later repair them, through validation of the lingering effects of early fear of intimacy and empowerment of parents to prevent next‐generation infant experiences of distrust.
Initiating the dialogue between infant mental health and family therapy: a qualitative inquiry and recommendations
Authors: Opie Jessica E. , Booth Anna T. , Rossen Larissa , Fivaz‐Depeursinge Elisabeth , Duschinsky Robbie , Newman Louise , McIntosh Jennifer E. , Hartley Eliza , Painter Felicity , Oppenheim David , Paul Campbell , Corboz‐Warnery Antoinette , Carr Alan , Philipp Diane A. , McHale James P. 
Published: November 2023

AbstractThis qualitative study explores infant‐family mental health experts' perspectives and experiences regarding the inclusion of infants in the family therapy setting. Infant socioemotional development is relational in nature and evolves in the context of both dyadic attachment relationships and broader multi‐person co‐parenting systems. Given this, we sought to understand why family therapy interventions involving families with infants rarely include the infant in a triangular or family systemic approach. Interviews were completed by clinical and/or research experts whose work integrates tenets of both infant mental health (IMH) and family theory and therapy. All interviewees brought at least 5 years of expertise and were actively engaged in the field. Interviewees expressed consistent beliefs that infants have a rightful and helpful place in family therapy approaches. They maintained that infants' innate social drive and communicative capacities position them to make meaningful and clinically significant contributions within family and systemic psychotherapy contexts. Noting that infants have remained on the periphery of these practices, experts advocated expansion and greater integration between IMH and family therapy, while preserving each field's distinctive identity. Experts reported that the interplay between IMH and family therapy fields has been uni‐directional as family systems concepts are embedded within IMH approaches, but few IMH premises are incorporated in mainstream family therapy practices. The disconnect was attributed to multiple factors, including graduate and professional training and theoretical, clinical, research, and sociocultural barriers, which were mutually reinforcing. Experts also identified clinical gains for both infants and family members when infants were meaningfully included in family interventions. Common ground was identified between the disciplines, with a belief that relationally distressed young children and parents are best served by clinical engagement with their network of relationships. Results call for greater collaboration between disciplines to challenge existing traditions and to more fully include infants in mainstream family therapy. Recommendations for integration of family therapy and IMH in clinical, theoretical, research, training, and sociocultural domains are offered.
Pharmacokinetic study of five components of Fuzheng Huayu tablets in healthy human plasma
Authors: Zhang Haibo , Hu Yeqing , Liu Xueying , Li Rongsheng , Pan Yifeng , Liu Chenghai , Yang Tao 
Published: November 2023

AbstractNatural medicines play a crucial role in clinical drug applications, serving as a primary traditional Chinese medicine for the clinical treatment of liver fibrosis. Understanding the in vivo metabolic process of the Fuzheng Huayu (FZHY) formula is essential for delving into its material basis and mechanism. In recent years, there has been a growing body of research focused on the mechanisms and component analysis of FZHY. This study aimed to examine the pharmacokinetics of FZHY in healthy volunteers following oral administration. Blood samples were collected at designated time intervals after the oral intake of 9.6‐g FZHY tablets. A UHPLC‐Q/Exactive method was developed to assess the plasma concentrations of five components post‐FZHY ingestion. The peak time for all components occurred within 10 min. The peak concentration (Cmax) values for amygdalin, schisandrin, and schisandrin A ranged from 3.47 to 28.80 ng/mL, with corresponding AUC(0–t) values ranging from 10.63 to 103.20 ng h/mL. For schisandrin B and prunasin, Cmax values were in the range of 86.52 to 229.10 ng/mL, and their AUC(0–t) values ranged from 375.26 to 1875.54 ng h/mL, indicating significant exposure within the body. These findings demonstrate that the developed method enables rapid and accurate detection and quantification of the five components in FZHY, offering a valuable reference for its clinical study.
Neutrophil extracellular traps in relationship to efficacy of systemic therapy for metastatic renal cell carcinoma
Authors: Xie Ruiyang , Shang Bingqing , Shi Hongzhe , Bi Xingang , Song Yan , Qu Wang , Bai Hongsong , Hu Linjun , Wu Jie , Cui Honglei , Du Gan , Guo Lei , Zheng Shan , Ying Jianming , Li Changling , Ma Jianhui , Zhou Aiping , Shou Jianzhong 
Published: November 2023

AbstractBackgroundThe efficacy of systemic therapy regimens, such as immune checkpoint inhibitors and tyrosine kinase inhibitors (IO‐TKI) and targeted therapy, for metastatic clear cell renal cell carcinoma (ccRCC) remains unpredictable due to the lack of effective biomarkers. Neutrophil extracellular trap (NET) plays an important role in promoting ccRCC. This study explores the NET predictive value of the efficacy in metastatic ccRCC.MethodsIn this retrospective study, patients with metastatic ccRCC who received targeted drugs and IO‐TKI were included. Immunofluorescence staining was utilized to quantify the levels of tissue NETs through cell counts of H3Cit(+) and MPO(+) cells.ResultsA total of 183 patients with metastatic ccRCC were enrolled, including 150 patients who received TKIs and 33 patients who received IO‐TKI. The levels of NETs in tumor tissue were significantly higher than in para‐tumor tissue (p < 0.001). In terms of predicting drug efficacy, a correlation between NET levels and progression‐free survival (PFS) was observed in the TKI with metachronous metastasis group (HR 1.73 [95% CI 1.02–2.91], log‐rank p = 0.037), while no correlation was observed in the TKI with synchronous metastasis group and IO‐TKI group. Regarding overall survival (OS), activated NET levels were associated with poor OS in both TKI (HR 1.60 [95% CI 1.05–2.43], log‐rank p  = 0.017) and IO‐TKI group (HR 4.35 [95% CI 1.06–17.82], log‐rank p =0.047). IMDC score (HR 1.462 [95% CI 1.030–2.075], p = 0.033) and tumor tissue NET levels (HR 1.733 [95% CI 1.165–2.579], p = 0.007) were independent prognostic risk factors for OS in patients with metastatic ccRCC.NET level was associated with poor OS in both TKI (HR 1.60 [95% CI 1.05–2.43], log‐rank p  = 0.017).ConclusionsThe active NET levels in tumor tissue can predict drug efficacy in patients with metastatic ccRCC who received systemic therapy. Elevated levels of NETs in tumor tissue were also associated with poor efficacy in OS.