bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing confounding in observational studies in orthopedic trauma surgery through expert panels: a systematic review
Authors: Groenwold Rolf H. H. , van Rossenberg L. X. , Smeeing D. P. J. , Houwert R. M. , Schoones J. W. , Muijs S. P. J. , Oner F. C. , de Jong Y. , van de Wall B. J. M. ,   for the NEXT study group
Published: January 2025

Abstract

Purpose
Confounding in observational studies can be mitigated by selecting only those patients, in whom equipoise of both treatments is secured by experts’ disagreement over optimal therapy.

Methods
We conducted a systematic review to identify observational studies in the field of orthopedic trauma surgery that utilized expert panels for patient inclusion in order to limit the potential for confounding.

Results
Four studies were identified that used expert panels to select participants based on expert disagreement. Derived from these studies and our own experience, recommendations were made regarding reporting of the size and composition of the expert panel, the information the expert panel receives, criteria for disagreement, selection of patients, and statistical analysis.

Conclusion
With this review we aim to provide insight into this study design and to stimulate discussions about the potential of expert panels to control for confounding in studies of medical treatments.
In the last 10 years, have our polytrauma patients become geriatric? The emergency trauma bay in the context of demographic change
Authors: Bindrich Sabrina , Mittlmeier Thomas , Falk Steffi S. I. 
Published: January 2025

Abstract

Purpose
One of the key challenges trauma centres are currently facing is the management of polytraumata in an ageing population. The aim of this study is to assess the extent to which demographic changes are reflected in the trauma bay population and the impact on geriatric polytrauma patient outcomes.

Methods
This is a retrospective single-centre cohort study of a level one trauma centre in Germany. The data were collected from the DGU TraumaRegister. All patients exhibiting vital signs who were primarily admitted to the trauma bay were included in the study. Patient characteristics were compared for years 2011 and 2021. Polytrauma was defined as ISS > 15, and patients aged 65 and over were assigned to the geriatric group.

Results
The study included 214 patients. During the study period, there was a significant increase in the mean age of patients (from 47.7 to 55.9 years) and in the proportion of geriatric patients (from 30.37 to 40.51%). Injury severity, as measured by the Injury Severity Score (ISS), also increased significantly. In the entire patient population, the proportion of patients discharged to their place of residence decreased, while the hospital mortality (2011: 9.63%; 2021: 21.52%) increased.

Conclusions
The ageing trauma bay population presents new challenges for medical staff, because polypharmacy, multiple comorbidities and frailty become more significant in an ageing population. Enhanced interdisciplinary management, particularly between trauma and geriatric specialists, may mitigate rising mortality rates. Geriatric trauma centres or at least more geriatric expertise might be required to improve the treatment and outcome in this changing population.
Prevalence, incidence, and complications of malnutrition in severely injured patients
Authors: Verheul Esmee A. H. , Dijkink Suzan , Krijnen Pieta , Hoogendoorn Jochem M. , Arbous Sesmu , Peters Ron , Velmahos George C. , Salim Ali , Yeh Daniel D. , Schipper Inger B. 
Published: January 2025

Abstract

Background
Severely injured patients may suffer from acute disease-related or injury-related malnutrition involving a marked inflammatory response. This study investigated the prevalence and incidence of malnutrition and its relation with complications in severely injured patients admitted to the intensive care unit (ICU).

Methods
This observational prospective cohort study included severely injured patients (Injury Severity Score ≥ 16), admitted to the ICU of five level-1 trauma centers in the Netherlands and United States. Malnutrition was defined as a Subjective Global Assessment score ≤ 5. Complications included systemic-, surgery-, and fracture-related complications, pneumonia, urinary tract infection, deep venous thrombosis, and pulmonary embolism. In-ICU and in-hospital mortality were recorded separately. The complication rate was compared between patients who had or developed malnutrition and patients who remained well-nourished, using multivariable logistic regression analysis.

Results
Of 100 included patients, twelve (12%) were malnourished at admission. Of the 88 well-nourished patients, 44 developed malnutrition during ICU admission, (ICU incidence 50%, 95% confidence interval [CI] 40–60%). Another 18 patients developed malnutrition at the ward (overall in-hospital incidence 70%, 95% CI 61–80%). The 62 patients who developed malnutrition and 12 patients who were malnourished upon admission had more complications than the 26 patients who remained well-nourished (58% vs. 50% vs. 27% respectively; p = 0.03; Odds Ratio 3.4, 95% CI 1.2–9.6).

Conclusions
50% of severely injured patients developed malnutrition during ICU admission, increasing to 70% during hospital admission. Malnutrition was related to an increased risk of complications. Recognition of sub-optimally nourished severely injured patients and assessment of nutritional needs could be valuable in optimizing their clinical outcomes.

Level of evidence
Level III, Prognostic/Epidemiological.
Long-term impact of emergency laparotomy on health-related quality of life
Authors: í Soylu Lív , Kokotovic Dunja , Kvist Madeline , Hansen Jannick Brander , Burcharth Jakob 
Published: January 2025

Abstract

Purpose
Emergency laparotomy can result in a range of physical and neuropsychiatric postoperative complaints, potentially impacting quality of life. This study aimed to assess the effect of emergency laparotomy on health-related quality of life (HRQoL) and how HRQoL influences the risk of readmission.

Method
HRQoL was assessed in patients undergoing emergency laparotomy during a 1-year period. Patients who completed the baseline HRQoL evaluation underwent a reassessment on postoperative day (POD) 30, 90, and 180. HRQoL was measured with the EQ5D index, and patients were categorized in ‘high’ and ‘low’ HRQoL. A decrease from high baseline HRQoL to low HRQoL by POD 30 was classified as ‘acquired low HRQoL’.

Results
All 215 patients who completed the baseline HRQoL evaluation were followed. On average, patients reported a lower mean (M) HRQoL from baseline (M = 0.876, standard deviation (SD) = 0.171) to POD 30 (M = 0.735, SD = 0.260). On POD 90, HRQoL had somewhat improved (M = 0.763, SD = 0.298), and by POD 180 HRQoL had returned to normal (M = 0.853, SD = 0.235). From the full-record population (n = 73), 20.5% acquired low HRQoL of whom 33% had not recovered by POD180. For patients with acquired low HRQoL, the risk of 180-day readmission was increased, and days alive and out of hospital within 180 days was reduced.

Conclusion
For most patients, HRQoL has returned to normal within 180 days after emergency laparotomy. However, patients who acquired low HRQoL after the procedure had an increased risk of long-term readmission.
Patient-specific implants combined with 3D-printed drilling guides for corrective osteotomies of multiplanar tibial and femoral shaft malunions leads to more accurate corrections
Authors: Oldhoff M. G. E. , Alvarez C. Posada , Ten Duis K. , Doornberg J. N. , Assink N. , IJpma F. F. A. 
Published: January 2025

Abstract

Purpose
The aim of this study was to evaluate the feasibility of using patient-specific implants (PSI) for complex shaft corrective osteotomies in multiplanar deformities of long bones in the lower extremities. Additionally, it aimed to investigate the added value of these implants by quantifying surgical accuracy on postoperative CT, comparing their outcomes to two commonly used techniques: 3D virtual visualizations and 3D-printed surgical guides.

Methods
Six tibial and femoral shaft corrective osteotomies were planned and performed on three Thiel embalmed human specimen. Depending on the specimen a different respective technique was used; 1) ‘3D Visualization’ using 3D virtual plan preoperatively and free-hand corrective osteotomy techniques with standard manually contoured plates; 2) ‘3D guided’ utilizing 3D surgical guides and manually contouring of conventional implant; and 3)‘3D PSI’ utilizing a 3D surgical guide with a patient-specific implant. Accuracy of the corrections was assessed through measurements for varus/valgus angulation, ante/recurvation, rotation and osteotomy plane error as quantified on postoperative CT-scans.

Results
Twelve corrective osteotomies were performed. For, the median difference between the surgical plan and postoperative CT assessment was 3.4°, 4.6°, and 2.2° for the ‘3D visualization’, ‘3D guided’, and ‘3D PSI’ methods respectively. Regarding ante/recurvation, the differences were 3.8°, 43.8°, and 1.2°, respectively. For rotation, the differences were 11.9°, 18.7°, and 3.5°, respectively. Discrepancies between planned and executed levels of osteotomy plane were 6.2 mm, 3.2 mm, and 1.4 mm, respectively.

Conclusion
PSIs with 3D-printed drilling guides for complex multiplanar corrective osteotomies of femoral and tibial shaft malunions is feasible and achieves accurate corrections. This technique enables precise determination of the osteotomy plane, guides correction in all three planes, and ensures satisfactory implant fitting; thus accurately translating the virtual surgical plan into clinical practice. The 3D PSI method is beneficial for complex cases with significant multiplanar deformities in bone anatomy, particularly with rotational malalignment.
Interpretability of fingerprint presentation attack detection systems: a look at the “representativeness” of samples against never-seen-before attacks
Authors: Carta Simone , Casula Roberto , Orrù Giulia , Micheletto Marco , Marcialis Gian Luca 
Published: January 2025

Abstract
Nowadays, fingerprint Presentation Attack Detection systems (PADs) are primarily based on deep learning architectures subjected to massive training. However, their performance decreases to never-seen-before attacks. With the goal of contributing to explaining this issue, we hypothesized that this limited ability to generalize is due to the lack of "representativeness" of the samples available for the PAD training. "Representativeness" is treated here from a geometrical perspective: the spread of samples into the feature space, especially near the decision boundaries. In particular, we explored the possibility of adopting three-dimensionality reduction methods to make the problem affordable through visual inspection. These methods enable visual inspection and interpretation by projecting data into two-dimensional spaces, facilitating the identification of weak areas in the decision regions estimated after the training phase. Our analysis delineates the benefits and drawbacks of each dimensionality reduction method and leads us to make substantial recommendations in the crucial phase of the training design.
The coupled Legendre-Hadamard condition for fiber-reinforced materials: three-dimensional solids and two-dimensional shells
Authors: Bîrsan Mircea , Shirani Milad , Steigmann David J. 
Published: January 2025

Abstract
Detailed derivations of the Legendre-Hadamard necessary conditions for energy-minimizing states of fiber-reinforced three-dimensional solids and two-dimensional shells are presented. The underlying conceptual framework is Cosserat elasticity theory in which the Cosserat rotation field controls the orientation of the embedded fibers. This is partially coupled to the continuum deformation gradient by the requirement that the fibers convect as material curves with respect to the matrix material in which they are embedded. The conditions obtained combine the effects of deformation and rotation and subsume previously obtained decoupled inequalities involving these effects separately.
Day-case gastrostomy insertion in children: an achievable reality
Authors: Thompson David , Allam Maddie , Dick Karen , Leigh Jo , Taylor Rhoda , Keys Charlie , Kitteringham Lara , Ron Ori , Stanton Michael , Stedman Francesca , Hall Nigel J. 
Published: January 2025

Abstract

Purpose
Recent efforts have sought to streamline gastrostomy insertion care, particularly length of stay (LOS). We report our initial experience with day-case gastrostomy (DCG) insertion.

Method
Retrospective review (April 2018–2024) of all primary gastrostomy insertions. Patients discharged the same day as the procedure were defined as DCG. Demographic, operative, and clinical data were recorded. All cases were treated according to a standardized feeding pathway.

Results
Of 432 gastrostomies formed, 15 were DCG; median age 3.5 (0.7–16.9) years, LOS 12 h (9–15 h). The most common indication was nutritional supplementation (n = 9). Gastrostomy technique was single-stage percutaneous rapid insertion of gastrostomy button (SPRING n = 5) or percutaneous endoscopic gastrostomy (PEG n = 10). Prior to insertion, 6/15 DCG were established on nasogastric (NG) feeding, 8 did not use NG feeding, and 1 had occasional NG feeds. The majority (13/15) were performed on morning operating lists. There were 4 minor complications; 2 required readmission.

Conclusion
DCG in selected cases is feasible and safe. Most cases were performed on morning operating list, but fewer than half had prior experience of nasogastric tube feeding. We suggest additional pathway modifications to improve DCG uptake.
Differential analysis of alternative splicing events in gene regions using residual neural networks
Authors: Ciccolella Simone , Denti Luca , Avila Cartes Jorge , Della Vedova Gianluca , Pirola Yuri , Rizzi Raffaella , Bonizzoni Paola 
Published: January 2025

Abstract
Several computational methods for the differential analysis of alternative splicing (AS) events among RNA-Seq samples typically rely on estimating isoform-level gene expression. However, these approaches are often error-prone due to the interplay of individual AS events, which results in different isoforms with locally similar sequences. Moreover, methods based on isoform-level quantification usually need annotated transcripts. In this work, we leverage the ability of deep learning networks to learn features from images and propose , a novel method for event-based AS differential analysis between two RNA-Seq samples. Our method does not rely on isoform abundance estimation, neither on a specific annotation. employs an image embedding scheme to represent the alignments of the two samples on the same region and utilizes a residual neural network to predict the AS events possibly expressed within that region. To our knowledge, is the first deep learning approach for performing an event-based AS analysis of RNA-Seq samples. To validate , we also address the lack of high quality AS benchmark datasets. For this purpose, we manually curated a set of regions exhibiting AS events. These regions were used for training our model and for assessing the predictions of our method. Our results highlight that achieves higher precision at the expense of a small reduction in sensitivity. The tool and the manually curated regions are available at https://github.com/sciccolella/deepSpecas.
The relationships between photochemical reflectance index (PRI) and photosynthetic status in radish species differing in salinity tolerance
Authors: Mohamed Elsayed , Tomimatsu Hajime , Hikosaka Kouki 
Published: January 2025

Abstract
Since photosynthesis is highly sensitive to salinity stress, remote sensing of photosynthetic status is useful for detecting salinity stress during the selection and breeding of salinity-tolerant plants. To do so, photochemical reflectance index (PRI) is a potential measure to detect conversion of the xanthophyll cycle in photosystem II. Raphanus sativus var. raphanistroides is a wild radish species closely related to domesticated radish, and is distributed throughout the coastal regions of Japan, where it is thought to be salt tolerant. In this study, we raised wild and domesticated radishes under various salt conditions and assessed growth, photosynthetic status, and PRI. When grown at mild salt stress (50 mM NaCl), wild radish leaves showed photosynthetic activity levels comparable to control plants, whereas the photosynthetic activity of domesticated radish was suppressed. This result suggests that wild radishes are more salt-tolerant than domesticated radishes. Although photosynthetic rate and the photochemical quantum yield were significantly correlated with PRI in both species, the PRI resolution was insufficient to distinguish differences in salt tolerance between wild and domesticated radish. Wild radish had a lower maximum quantum yield (Fv/Fm) when grown under moderate salt stress (200 mM NaCl), suggesting chronic photoinhibition. The relationship between non-photochemical quenching (NPQ) and PRI was significant when leaves with chronic photoinhibition were eliminated but this relationship was not significant when they were included. In contrast, the relationship between photosynthesis and PRI was significant regardless of whether leaves displayed chronic photoinhibition or not. We conclude that PRI is useful to detect relatively large reductions in photosynthetic rate under salinity stress, and that care should be taken to evaluate NPQ from PRI.
Barriers to product return in a circular supply chain: a case from a retailing industry
Authors: Hashemi Petrudi Seyed Hamid , Sharifpour Arabi Hojatallah 
Published: January 2025

Abstract
The circular supply chain (CSC) plays a pivotal role in delivering sustainable products to end users, profoundly affecting organizational performance and societal welfare. In this ecosystem, effective Product Return Management (PRM) is crucial, as consumers play a pivotal role in returning used products for reuse or recycling. Despite its significance in waste reduction and attaining environmental and economic goals, scant research has explored product return barriers within CSC. This study bridges this gap by investigating and prioritising these barriers to enhance the circular economy. Employing a systematic literature review (SLR), we extracted and screened 13 product return barriers in CSC using the Grey Delphi method. Subsequently, we introduced an enhanced version of the Group Grey-Best–Worst Method (GG-BWM), a novel approach that harmonises expert judgments by addressing uncertainties through Grey Theory and incorporating both individual-level and group-level inconsistency ratios. The findings highlight lack of motivation, lack of consumer awareness, and lack of proper infrastructure as the most critical barriers. Furthermore, sensitivity analysis conducted across 11 scenarios emphasises the significance of our results. This study contributes to the group multiple criteria decision making (MCDM) methods and CSC literature, while offering actionable insights practitioners seeking to improve the effectiveness of their CSC strategies.
Examination of heavy metal concentrations and their interaction with anthropogenic sources in Ermenek Dam Lake (Turquoise Lake)
Authors: Argun Yusuf Alparslan 
Published: January 2025

Abstract
This study aims to determine the spatial distribution of heavy metal pollution in Ermenek Dam Lake, water quality assessment and pollution sources. For this purpose, samples were taken 6 times a year from 12 points determined in 2024. Physico-chemical parameters and heavy metals were analyzed in the study. Using the analysis results, indexes such as Water Quality Index and Heavy Metal Pollution Index were calculated. The results show that the lake water complies with TS 266 and WHO standards. The index results indicate that the lake water is at low pollution and risk level and is safe. The distribution and sources of heavy metals were examined using correlation analysis, Principal Component Analysis and Hierarchical Cluster Analysis. Correlation analyses showed that there were significant relationships between pH, temperature, conductivity, dissolved oxygen and TDS and heavy metals. PCA results revealed that Zn was positively correlated with temperature and pH, while Mn and Ni were inversely correlated. The alignment of Pb, Cu and Cd in the same direction showed that these parameters were affected by common sources. HCA results showed that Cr and Fe have similar transport and source properties, while Mn and Ni are affected by different sources. In general, it was determined that heavy metal pollution in lake water was at low levels and local concentrations were present. The study revealed the effects of anthropogenic activities on the lake ecosystem. The findings of the study provide a guiding basis for water quality management in similar hydrological systems.

Graphical abstract
Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD
Authors: Forbes Elana J. , Tiego Jeggan , Langmead Joshua , Unruh Kathryn E. , Mosconi Matthew W. , Finlay Amy , Kallady Kathryn , Maclachlan Lydia , Moses Mia , Cappel Kai , Knott Rachael , Chau Tracey , Sindhu Vishnu Priya Mohanakumar , Bellato Alessio , Groom Madeleine J. , Kerestes Rebecca , Bellgrove Mark A. , Johnson Beth P. 
Published: January 2025

Abstract
Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism.