bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meteorology of ‘ridging high’ rainfall over the KwaZulu‐Natal coastal plains
Authors: Jury Mark R. 
Published: October 2023

AbstractThe meteorology of ridging highs on the coast of KwaZulu‐Natal (KZN) South Africa was studied using Principal Component (pc) analysis of daily ERA5 sea level air pressure (SLP) fields 1980–2021. The second pc mode time score representing ridging highs, was associated with rain‐showers moving northeast‐ward along the KZN coast. Temporal analysis revealed an Oct‐Dec peak occurrence and 12‐day pulse intervals induced by the eastward migration of atmospheric Rossby waves in early summer. From a ranking of SLP pc2 and associated daily time series, a case study emerged: 14–18 Nov. 2009. This ridging high weather scenario had cold southerly winds subsiding over the warm Agulhas Current. Surface moisture fluxes >350 W/m2 create a buoyant airmass that slows and lifts over the coastal plains, inducing shallow clouds that reduce net solar radiation and potential evaporation. Interannual variability of ridging highs was studied by filtering the daily SLP pc2 time score to retain seasonal fluctuations and correlating with regional fields of SST. This revealed warming in the SW Indian Ocean associated with positive phase Indian Ocean Dipole (IOD). The atmospheric circulation forms a NW trough over Madagascar which deforms eastward moving mid‐latitude anticyclones. Thus, ridging highs that bring beneficial Oct‐Dec rains to the coast of KZN depend on downstream climate coupling with the IOD. Long‐term trends from a coupled model simulation 1980–2100 suggest a poleward retreat of the anticyclonic ridge, consistent with declining Durban‐area river flow in early summer.
Mindfulness Makes Employees More Creative? The Mediating Role of Psychological Capital and Creative Process Engagement
Authors: Li Xiao , Zhang Chen , Li Changde , Shi Wendian , Wang Feng , Wang Qiangqiang , Zhang Yanan 
Published: October 2023

ABSTRACTPrevious studies on mindfulness and creativity have focused on the beneficial effects of mindfulness on concentration. However, few have explored this from the perspective of psychological resources. Based on resource conservation theory, this study focuses on the positive psychological functions of mindfulness and how they complement the psychological resources depleted in the performance of creativity. Thus, guaranteeing the completion of creativity‐related activities. We used a three‐time lag design and analyzed reports from 404 employees and 85 supervisors to explore the impact of employees' mindfulness on their creativity and the chain‐mediating role of psychological capital and creative process engagement in the relationship between the two. The results indicated that employees' mindfulness can influence their creativity not only directly but also through the mediation of just creative process engagement as well as through the chain mediation of psychological capital and creative process. The findings revealed the psychological mechanisms through which employees' mindfulness impacts their creativity, providing a scientific basis for exploring how to effectively enhance employees' creativity and dissipating the doubts raised about the current widespread use of mindfulness in organizations.
The associations of coffee consumption, coffee types, and caffeine metabolites with periodontitis: Results from NHANES 2009–2014
Authors: Chen Qiansi , Ge Ruiyang , Wu Yuxuan , Wu Yuying , Yang Han , Yu Yiming , Deng Qingrong , Qiu Yu , He Baochang , Yan Fuhua , Li Yanfen , Chen Fa 
Published: October 2023

AbstractBackgroundCoffee is one of the world's most popular beverages and is the main dietary source of caffeine for most people. The various molecular effects of caffeine suggest that it may enhance bone loss. The purpose of the present study was to investigate the relationship of coffee, coffee types, and caffeine metabolites with periodontitis.MethodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014. Total coffee and different types of coffee consumption were acquired through a 24‐h dietary recall. Urinary caffeine metabolites were quantified using high‐performance liquid chromatography–electrospray ionization–tandem quadrupole mass spectrometry (HPLC‒ESI‒MS/MS). The association of coffee, coffee types, and caffeine metabolites with periodontitis and its severity were assessed using multivariable logistic regression.ResultsA total of 3309 eligible participants were included. After adjusting for potential confounding variables, a positive association was observed between coffee consumption (particularly certain types of coffee) and periodontitis. Notably, a positive correlation was also found between total coffee intake and the severity of periodontitis. Additionally, for urinary caffeine metabolites, there was a significant positive association between 1‐methyluric acid (1‐MU), 1,3‐dimethyluric acid (1,3‐DMU), 3,7‐dimethyluric acid (3,7‐DMU), 1,7‐dimethylxanthine (1,7‐DMX), or 5‐actlyamino‐6‐amino‐3‐methyluracil (AAMU) and periodontitis, with adjusted odds ratios and 95% confidence intervals of 1.10 (1.02, 1.19), 1.86 (1.05, 3.29), 0.94 (0.90, 0.98), 1.29 (1.03, 1.62), and 1.15 (1.05, 1.26), respectively.ConclusionsThe present study suggests a positive association of coffee intake (especially certain coffee types) and caffeine metabolites (1‐MU, 1,3‐DMU, 3,7‐DMU, 1,7‐DMX, and AAMU) with periodontitis and its severity.
Climate and atmospheric circulation during the Early and Mid‐Holocene inferred from lake‐carbonate oxygen‐isotope records from western Ireland
Authors: Holmes Jonathan A. , Tindall Julia , Jones Matthew , Holloway Max , Roberts Neil , Feeser Ingo 
Published: October 2023

ABSTRACTThe Early to Mid‐Holocene experienced marked climate change over the northern hemisphere mid‐latitudes in response to changing insolation and declining ice volume. Oxygen isotopes from lake sediments provide a valuable climate proxy, encoding information regarding temperature, hydroclimate and moisture source. We present oxygen‐isotope records from two lakes in western Ireland that are strongly influenced by the North Atlantic. Excellent replication between the records suggests they reflect regional, not local, influences. Carbonate oxygen‐isotope values peaked at the start of the Holocene, between 11.2 and 11.1 cal ka bp, and then decreased markedly until 6 cal ka bp at both sites. Palaeoecological evidence supports only modest change in temperature or hydroclimate during this interval and we therefore explain the decrease primarily by a reduction in the oxygen‐isotope composition of precipitation (δ18Oppt). We show a similar decrease in δ18O values in a forward model of carbonate isotopes between 12–11 and 6–5 cal ka bp. However, the inferred reduction in δ18Oppt between the Early and Mid‐Holocene in the model is mainly linked to a decrease in the δ18O of the ocean source water from ice sheet melting whereas the lake carbonate isotope records are more consistent with changes in the transport pathway of moisture associated with atmospheric circulation change as the dominant cause.
Quality improvement of soybean meal by yeast fermentation based on the degradation of anti‐nutritional factors and accumulation of beneficial metabolites
Authors: Cao Yazhuo , Lu Jian , Cai Guolin 
Published: October 2023

AbstractBackgroundSoybean meal (SBM) is the main protein source for animal diets but its anti‐nutritional constituents affect animal growth and immunity. The yeast culture of soybean meal (SBM‐YC) that fermented with yeast and hydrolyzed by protease simultaneously could reduce anti‐nutritional factors effectively and accumulate beneficial metabolites.ResultsThe crude protein and acid‐soluble protein content of SBM‐YC reached 542.5 g kg−1 and 117.2 g kg−1, respectively, and the essential amino acid content increased by 17.9%. Raffinose and stachyose decreased over 95.0%, and the organic acid content such as acetic acid, butyric acid, citric acid, lactic acid, succinic acid, and propionic acid produced by fermentation reached 6.1, 3.8, 3.6, 2.5, 1.2, and 0.4 g kg−1, respectively. As biomarkers of yeast culture, nucleosides and their precursors reached 1.7 g kg−1; in particular, the inosine content increased from 0 to 0.3 g kg−1. The total antioxidant capacity, 2,2'‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) free radical activity, metal chelating ability, and 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) scavenging ability were increased by 50.3%, 46.1%, 43.9%, and 20.6%, respectively.ConclusionThis study established a diversified evaluation index, which could lay the foundations for the production and quality control of SBM‐YC in the future. © 2023 Society of Chemical Industry.
Analysis of association of sensory and laboratory assessments for quality and consumer acceptability of steamed East Africa highland bananas
Authors: Akankwasa Kenneth , Marimo Pricilla , Bouniol Alexandre , Tumuhimbise Robooni , Asasira Moreen , Kisakye Sarah , Khakasa Elizabeth , Tinyiro Edgar , Mukasa Yusuf , Tukashaba Living , Namuddu Mary G. , Ssenyonga Peter B. , Dufour Dominique , Tushemereirwe Wilberforce , Nowakunda Kephas 
Published: October 2023

AbstractBACKGROUNDThe relevance of several characteristics for the acceptability of steamed East Africa bananas (matooke) was assessed using consumer‐preferred characteristics, the overall liking scores, check‐all‐that‐apply (CATA) and the Just About Right scale. The study was conducted in rural and urban locations in three banana growing regions of Uganda. Two landraces and two hybrids were processed into matooke. Twelve trained panellists evaluated color, taste and texture sensory characteristics.RESULTSConsumers scored matooke from landraces as the most liked. The CATA test showed that the most important characteristics were: smooth mouthfeel, soft to the touch, not sticky, moldable, deep yellow color, attractive, good matooke taste and smell. Principal component analysis confirmed that most of the preferred sensory characteristics were associated with the local genotypes, whereas the less preferred characteristics were associated with hybrids. Correlation analysis revealed strong positive correlations between the consumer assessed characteristics, hardness by touch, softness to touch and yellowness, as well as quantitative laboratory characteristics (moldable, hardness by touch, softness and yellowness) of the steamed matooke. Color assessed by consumers was strongly correlated with the laboratory‐assessed color indicators.CONCLUSIONThe strong associations observed between laboratory‐assessed and consumer‐based characteristics (moldable by touch and yellowness) suggest the possibility of predicting consumer characteristics using quantitative laboratory sensory assessments. Matooke taste as assessed by consumer panel is strongly associated with smooth texture and deep yellow color, which were the characteristics associated with landraces in the laboratory sensory assessment. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Global epidemiological trends and variations in the burden of gallbladder cancer
Authors: Vuthaluru Srineil , Sharma Prateek , Chowdhury Sanjib , Are Chandrakanth 
Published: October 2023

AbstractBackgroundGallbladder cancer (GBC) is a rare but lethal malignancy with a dismal prognosis. The aim of this study is to analyze the burdens and trends of GBC across the world based on geography, socioeconomic development (based on human development index [HDI]), and gender.MethodsGLOBOCAN 2020 database was used to extract data (2020−2040) relating to the incidence and mortality of GBC across the world.ResultsAsia had the highest burden of GBC with India and China contributing to majority of the absolute burden. The burden of GBC by age standardized rate was highest in Latin America (Bolivia and Chile) and Southeast Asia (Bangladesh and Nepal). Medium HDI countries had a higher mortality rate compared to very high HDI countries. Females had a higher predilection for GBC across different regions and socioeconomic groups. GBC burden is expected to significantly increase across the world by 2040 with variable trends across different regions, age groups, and genders.ConclusionThe global burden of GBC will significantly increase over the next two decades with marked regional and demographic variations. The results of this study will empower national and global health leaders to develop policies to address the increasing burden of this lethal malignancy.
Oncologic anthropology: Global variations in breast cancer risk, biology, and outcome
Authors: Newman Lisa 
Published: October 2023

AbstractThe global breast cancer burden is growing. Of 19.3 million new cancers diagnosed in 2020, 2.26 million were breast, surpassing lung as the most commonly diagnosed worldwide. Breast cancer is the fourth most common cause of cancer deaths worldwide, and the leading cause of death in females. Incidence and mortality rates are projected to rise disproportionately in low and middle‐income countries, a consequence of socioeconomic factors and differences in tumor biology related to genetic ancestry.
Global trends in the incidence and mortality of pancreatic cancer based on geographic location, socioeconomic status, and demographic shift
Authors: Sharma Prateek , Vuthaluru Srineil , Chowdhury Sanjib , Are Chandrakanth 
Published: October 2023

AbstractBackgroundPancreatic cancer (PC) is a lethal malignancy with a significantly rising rate of incidence and mortality. This study aims to describe the influence of geography, socioeconomic development (based on the Human Development Index [HDI]), gender, and demographic shift on the temporal trends in the global burden of PC.MethodsData (2020–2040) relating to the incidence, mortality of PC, and demographic shifts based on continents and HDI areas were extracted from GLOBOCAN 2020.ResultsPC was associated with a higher socioeconomic status. Asia contributed to the majority of the burden, led by China. Advanced age (≥65 years) contributed to the majority of the burden in all socioeconomic regions except in Medium HDI and Low HDI countries, where the younger population (<65 years) contributed more. Females contributed to a higher burden in certain countries. Future trends for 2040 showed a >60% increase in the incidence and mortality of PC with an associated demographic shift.ConclusionThe global burden of PC is expected to rise significantly over the next few decades regardless of geography, socioeconomic development, age, and gender. Advance knowledge of this data can help to formulate strategies and public health policies to specifically target countries and populations at risk.
A tripartite approach toward ending cancer as we know it, for everyone: An American Cancer Society perspective
Authors: Dahut William L. , Kamal Arif H. , Lacasse Lisa A. , Sanders Kathryn M. , Knudsen Karen E. 
Published: October 2023

AbstractGaps in the cancer care continuum are vast, both in the United States and globally. The American Cancer Society orchestrates an integrated, tripartite approach toward improving the lives of cancer patients and their families through research, advocacy, and patient support. With a focus on eradicating cancer disparities, the American Cancer Society aims to scale and deploy best practices worldwide through partnerships, to ensure everyone has an opportunity to prevent, detect, treat, and survive cancer.
Use of early postoperative intraperitoneal 5‐fluorouracil with index cytoreduction improves survival with secondary cytoreductive surgery
Authors: Sugarbaker Paul H. , Chang David 
Published: October 2023

AbstractBackgroundIn patients with appendiceal mucinous neoplasm with peritoneal dissemination, a cytoreductive surgery (CRS) with perioperative chemotherapy may result in long‐term survival. Disease progression may require secondary cytoreductive surgery (SCRS) and other treatments in selected patients to improve survival and preserve an optimal quality of life.MethodsThe clinical‐ and treatment‐related variables associated with the index CRS and SCRS were statistically assessed for impact on survival after SCRS.ResultsA total of 186 of 687 complete CRS patients (27.1%) had SCRS. Median follow‐up was 10 years and median survival was 12 years. In 95 males (51%) the median age was 45.0 years. Survival benefit with SCRS was observed if early postoperative intraperitoneal chemotherapy (EPIC) with 5‐fluorouracil (EPIC 5‐FU) or hyperthermic intraperitoneal chemotherapy (HIPEC) plus EPIC 5‐FU was used with the index CRS (hazard ratio [HR]: 0.6, p = 0.0360; HR: 0.4, p = 0.0004, respectively). By propensity matching of 51 pairs of patients, EPIC 5‐FU used with index CRS caused a survival advantage compared to HIPEC alone (p = 0.0100) with index CRS (p = 0.0100).ConclusionsUse of EPIC 5‐FU at a complete index CRS was a prognostic variable that improved survival in patients requiring SCRS. Further investigations into the benefits of antiadhesion treatments with CRS and HIPEC are warranted.
Impact of safety‐net hospital burden on achievement of textbook oncologic outcomes following resection in for stage I–IV colorectal cancer
Authors: Wong Paul , Victorino Gregory P. , Miraflor Emily , Alseidi Adnan , Maker Ajay V. , Thornblade Lucas W. 
Published: October 2023

AbstractBackground and ObjectivesTextbook oncologic outcome (TOO) is a benchmark for high‐quality surgical cancer care but has not been studied at safety‐net hospitals (SNH). The study sought to understand how SNH burden affects TOO achievement in colorectal cancer.MethodsThe National Cancer Database was queried for colorectal cancer patients who underwent resection for stage I‐III plus stage IV with liver‐only metastases (2010–2019). TOO was defined as R0 resection, AJCC‐compliant lymphadenectomy (>12 nodes), no prolonged LOS, no 30‐day mortality/readmission, and receipt of stage‐appropriate adjuvant chemotherapy.ResultsOf 487,195 patients, 66.7% achieved TOO. Lower achievement was explained by adequate lymphadenectomy (87.3%), non‐prolonged LOS (76.3%), and receipt of adjuvant chemotherapy in stage III (60.3%) and IV (54.1%). Treatment at high burden hospitals (HBH, >10% Medicaid/uninsured) was a predictor of non‐TOO (Stage I/II: OR 0.83, III: OR 0.86, IV: OR 0.83; all p < 0.001). Achieving TOO was associated with decreased mortality (Stage I/II: HR 0.49, III: HR 0.48, IV: HR 0.57; all p < 0.001), and HBH treatment was a predictor of mortality (Stage I/II: HR 1.09, III: HR 1.05, IV: HR 1.07; all p < 0.05).ConclusionsTreatment at higher SNH burden hospitals was associated with less frequent TOO achievement and increased mortality. Quality improvement targets include receipt of adjuvant chemotherapy and avoidance of prolonged LOS.
Leiomyosarcoma of the rectum: A systematic review of recent literature
Authors: Annicchiarico Alfredo , Montali Filippo , Baldinu Manuel , Casali Lorenzo , Virgilio Edoardo , Costi Renato 
Published: October 2023

AbstractLeiomyosarcomas (LMSs) are rare tumors originating from the muscular layer. We performed a literature review of cases of confirmed rectal leiomyosarcomas (rLMSs) to clarify the history of such an infrequent tumor arising at such an uncommon location. In this research local recurrence was related to poorly differentiated rLMS and no other association between recurrence and any criteria was found. Concerning overall survival (OS), rLMS patients developing recurrence presented shorter longevity compared with the group without.
Nanotargeted Cationic Lipid Microbubbles Carrying HSV‐TK Gene Inhibit the Development of Subcutaneous Liver Tumor Model After HIFU Ablation
Authors: Liu Yan , Zhang Yudi , Du Di , Gu Xue , Zhang Xian , Hong Guoqing , Lai Xing 
Published: October 2023

ObjectivesHigh‐intensity focused ultrasound (HIFU) has been widely used in clinical settings and has achieved suitable results in the treatment of many cancerous or noncancerous diseases. However, in the treatment of liver cancer, because the tumor is located deep within the liver tissue, when ultrasound penetrates the tissue, it will inevitably produce sound energy attenuation. This attenuation limits the reliability of HIFU treatment, reduce the efficacy of HIFU, and increase the risk of tumor recurrence.MethodsCationic microbubbles (CMB) were successfully linked with GPC3 and HSV‐TK plasmids, and targeted gene‐carrying CMB were successfully constructed. Moreover, the gene‐targeted cation microbubbles had suitable targeting and can specifically bind with liver cancer cells.ResultsThe HSV‐TK transfection efficiency was high and had a significant inhibitory effect on the proliferation and invasion of liver cancer cells. After the gene‐carrying cation microbubbles entered the animal body, they had a great targeting effect in vivo. They transfected the target genes into liver cancer cells, and the HSV‐TK/GCV system initiated cell death, demonstrating that these targeted microbubbles, enhanced HIFU treatment.ConclusionsOverall, CMB combined with a GPC3 antibody and HSV‐TK plasmid can target residual subcutaneous liver tumor cells under the guidance of GPC3 antibody, and kill residual subcutaneous liver tumor cells under the action of ultrasound, thus enhancing the therapeutic effect of HIFU on liver cancer.