bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iranian psoriasis registry: Research protocol and preliminary results of a pilot study
Authors: Robati Reza M. , Pourani Mohammad Reza , Sadeghi Zahra , Mardani Ghazal , Hasanzadeh Saba , Moravvej Hamideh , Nasiri Soheila , Namazi Nastaran , Dadkhahfar Sahar , Gheisari Mehdi , Shahidi Dadras Mohammad , Ghalamkarpour Fariba , Abdollahimajd Fahimeh 
Published: November 2023

AbstractBackgroundPsoriasis as a common cutaneous inflammatory disease affect many aspects of patients' life. Disease registries render it possible to collect valuable data regarding a disease prevalence and burden as well as long‐term observations concerning possible therapeutic regimens.MethodsThis registry was designed for the ongoing systematic data collection on patients with psoriasis at two referral dermatology centers in Iran. The pilot phase of the registry was used to identify possible obstacles in the application and execution of systematic registration.ResultsA total of 281 patients were registered with the mean age of 42.02 years. The disease duration was 12.06 ± 10.90 years with the variety of clinical presentations. There was no significant difference between males and females in the age of disease onset (p = 0.53). Notably, 167 patients had children. Among them, 13 had children with psoriasis. The gender of the affected parent did not affect the possibility of psoriasis transmission to the child, and no significant difference was seen between the two sexes (P = 0.569). Regarding treatment, 99.4% of patients (n = 280) had used topical agents, 52.3% (n = 147) biologics, and 60.9% (n = 171) nonbiologic medications.ConclusionClinical trials report the efficacy and safety data regarding limited study populations in a restricted time window, and the results may differ from the general population. This highlights the importance of registry‐based studies for collecting and analyzing longitudinal information. In terms of long‐term disease complications such as malignancies, cardiovascular events, and serious adverse events, registry‐based studies will help clinicians better recognize and manage each disease.
Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial
Authors: Parvizi Mohammad Mahdi , Saki Nasrin , Samimi Soodabeh , Radanfer Roya , Shahrizi Mohammad Miaad , Zarshenas Mohammad Mehdi 
Published: November 2023

AbstractIntroductionInfraorbital hyperpigmentation represents one of the most prevalent conditions in cosmetic dermatology. To treat this condition, many patients prefer natural remedies. This study explored the efficacy of topical castor oil cream in treating patients with infraorbital hyperpigmentation.MethodsWe conducted an exploratory single‐arm clinical trial at the Shahid Faghihi Dermatology Clinic and Molecular Dermatology Research Center of Shiraz University of Medical Sciences, Shiraz, Iran, during 2021–2022. Using the convenience sampling method, we enrolled 25 patients with infraorbital hyperpigmentation. We instructed the patients to apply topical castor oil cream twice daily for 2 months. The darkness, melanin, and erythema levels were evaluated by VisioFace® 1000 D and SkinColorCatch® devices. We used a visual analog scale to assess skin laxity, wrinkles, and patient satisfaction. Data analysis was done with Stata version 14.2.ResultsThe data of 22 patients with a mean age of 40.92 ± 7.33 years were analyzed. The VisioFace® scores decreased significantly by the end of the study [right eyes: mean difference (MD): ‐5.63 (95% CI: −7.12 to −4.15), p < 0.001; left eyes: MD: ‐5.91 (95% CI: −7.46 to −4.36), p < 0.001]. Moreover, castor oil cream significantly reduced the melanin level, wrinkles, and skin laxity in the infraorbital region (p < 0.05).ConclusionsCastor oil cream seems to be an effective alternative for treating infraorbital hyperpigmentation. Randomized clinical trials are needed to confirm our findings.
Individual differences in dissimilation: Do some people make more distinctions among targets' personalities than others?
Authors: Carlson Erika N. , Elsaadawy Norhan , Pringle Victoria , Rau Richard 
Published: November 2023

AbstractObjectivePeople differ in how positively they tend to see others' traits, but people might also differ in how strongly they apply their perceptual styles. In two studies (Ns = 355, 303), the current research explores individual differences in how variable people's first impressions are across targets (i.e., within‐person variability), how and why these differences emerge, and who varies more in their judgments of others.MethodParticipants described themselves on personality measures and rated 30 (Study 1) or 90 (Study 2) targets on Big Five traits.ResultsUsing the extended Social Relations Model (eSRM), results suggest that within‐person variability in impressions is consistent across trait ratings. People lower in extraversion, narcissism and self‐esteem tended to make distinctions across targets' Big Five traits that were more consistent with other perceivers (sensitivity). Furthermore, some people more than others tended to consistently make unique distinctions among targets (differentiation), and preliminary evidence suggests these people might be higher in social anxiety and lower in self‐esteem and emotional stability.ConclusionOverall then, a more complete account of person perception should consider individual differences in how variable people's impressions are of others.
One year later: Longer‐term maintenance effects of a digital intervention to change personality traits
Authors: Stieger Mirjam , Flückiger Christoph , Allemand Mathias 
Published: November 2023

AbstractObjectiveRecent research suggests that personality traits can be changed by psychological interventions. However, it is unclear whether these intended personality changes can be maintained or merely reflect ephemeral shifts.MethodThe present study reports 1‐year follow‐up effects of a 3‐month digital intervention for personality trait change. Personality traits were measured before the intervention (pretest: N = 1523), directly after the intervention (posttest: n = 554), and 3 months (follow‐up 1: n = 437) and 1 year (follow‐up 2: n = 157) after the end of the intervention.ResultsAttrition analyses suggest that participants who completed the 1‐year follow‐up were significantly more open to experience (d = 0.19), less neurotic (d = 0.20), more agreeable (d = 0.35) and more conscientious (d = 0.27) than participants who did not complete the 1‐year follow‐up. Also, until the 1‐year follow‐up, personality trait changes achieved remained stable (for those who wanted to increase in extraversion and conscientiousness) or even changed further in the desired direction (for those who wanted to decrease in neuroticism).ConclusionThese results suggest that changes in personality traits due to a targeted intervention are not just ephemeral shifts and can even continue.
The genetic diversity in the ancient human population of Upper Xiajiadian culture
Authors: Zhu Kong‐Yang , Zhang Zhi‐Ping , Tao Le , Jiang Run‐Qi , Huang Wen‐Bo , Sun Yong‐Gang , He Hai‐Feng , Fu Hui‐Lin , Ma Hao , Yang Xiao‐Min , Guo Jian‐Xin , Jia Xin , Wang Chuan‐Chao 
Published: November 2023

AbstractThe West Liao River (WLR) and Yellow River (YR) basins are two major centers of millet farming in northern China. The result from flotation analyses and the spatial distribution of archeological sites indicate that two distinct survival strategies—agriculture and pastoralism were adopted in the southern and western regions of the WLR. Previous studies of ancient populations from the western area of the WLR suggested a correlation between a pastoral economy in the Bronze Age Upper Xiajiadian culture with a decreased genetic affinity with YR farmers. However, the population history of the southern WLR is unknown mainly due to the lack of ancient genetic data. Here we report the genomic data of an ancient individual from the Majiazishan site from the Late Bronze Age southern WLR region associated with Upper Xiajiadian culture. Unlike individuals from western WLR, this individual derived ancestry entirely from Late Neolithic YR farmers. We found a genetic substructure of the ancient human population of Upper Xiajiadian culture, which is consistent with the differences in the subsistence strategies of western and southern WLR. Climate deterioration led to different populations occupying the west and the south, respectively, in the WLR: the nomadic population from the Amur River (AR) in the west and the agricultural population from the YR in the south.
An analysis of time conceptualisations and good care in an acute hospital setting
Authors: Dewar Jan , Cook Catherine , Smythe Elizabeth , Spence Deborah 
Published: November 2023

AbstractThis study articulates the relationship between conceptualisations of time and the accounts of good care in an acute setting. Neoliberal healthcare services, with their focus on efficiencies, predominantly calculate quality care based on time‐on‐the‐clock workforce management planning systems. However, the ways staff conceptualise and then relate to diverse meanings of time have implications for good care and for staff morale. This phenomenological study was undertaken in acute medical–surgical wards, investigating the contextual, temporal nature of care embedded in human relations. The study interviews involved 17 participants: 11 staff, 3 previous patients and 3 family members. Data were analysed iteratively to surface the phenomenality of temporality and good care. The following constituents of the data set are explored that together illustrate the relationship between the conceptualisations of time and the accounts of good care in an acute setting: patient time as a relational journey; patient time, sovereign time and time ethics and time, teamwork and flow. The findings are clinically significant because they offer a contrasting narrative about the relationship between time and care quality. The experiences of giving and receiving good care are indivisible from how temporality is experienced and the social relations within which care is embedded. Healthcare staff experience temporality differently from patients and families, a point that healthcare participants in this study appeared to comprehend and accommodate. For all parties involved in providing care or being the recipient of care, however, the capacity to be present was valued as a humanising ethic of care. Our study reinforces the importance of not creating presumptive binaries about which temporal structures are more or less humanising—there is a place for a fast‐paced tempo, which can be experienced as being in the flow of human relations with one's team and on behalf of patients.
Low‐cost, 3D printed irradiation system for in vitro photodynamic therapy experiments
Authors: Acquah Chris , Pabis Zachary , Seth Sourav Kanti , Levi Liraz , Crespo‐Hernández Carlos E. 
Published: November 2023

AbstractThe development of a suitable irradiation setup is essential for in vitro experiments in photodynamic therapy (PDT). While various irradiation systems have been developed for PDT, only a few offer practical and high‐quality setups for precise and reproducible results in cell culture experiments. This report introduces a cost‐effective illumination setup designed for in vitro photodynamic treatments. The setup consists of a commercially available light‐emitting diode (LED) lamp, a cooling unit, and a specially designed 3D‐printed enclosure to accommodate a multiwell plate insert. The LED lamp is versatile, supporting various irradiation wavelengths and adjustable illumination fields, ensuring consistent and reliable performance. The study evaluates the setup through various parameters, including photon flux density, illumination uniformity, photon distribution across the multiwell plate, and temperature changes during irradiation. In addition, the effectiveness of the LED‐based illumination system is tested by treating mouse mammary breast carcinoma cells (4T1) with Rose Bengal and LED irradiation at around 525 nm. The resulting IC50 of 5.2 ± 0.9 μM and a minimum media temperature change of ca. 1.2°C indicate a highly promising LED‐based setup that offers a cost‐effective and technically feasible solution for achieving consistent, reproducible, and uniform irradiation, enhancing research capabilities and potential applications.
Polymerase iota plays a key role during translesion synthesis of UV‐induced lesions in the absence of polymerase eta
Authors: Martins Davi Jardim , Singh Jenny Kaur , Jahjah Tiya , Vessoni Alexandre Teixeira , Leandro Giovana da Silva , Silva Matheus Molina , Biard Denis Serge François , Quinet Annabel , Menck Carlos Frederico Martins 
Published: November 2023

AbstractXeroderma pigmentosum (XP) variant cells are deficient in the translesion synthesis (TLS) DNA polymerase Polη (eta). This protein contributes to DNA damage tolerance, bypassing unrepaired UV photoproducts and allowing S‐phase progression with minimal delay. In the absence of Polη, backup polymerases perform TLS of UV lesions. However, which polymerase plays this role in human cells remains an open question. Here, we investigated the potential role of Polι (iota) in bypassing ultraviolet (UV) induced photoproducts in the absence of Polη, using NER‐deficient (XP‐C) cells knocked down for Polι and/or Polη genes. Our results indicate that cells lacking either Polι or Polη have increased sensitivity to UVC radiation. The lack of both TLS polymerases led to increased cell death and defects in proliferation and migration. Loss of both polymerases induces a significant replication fork arrest and G1/S‐phase blockage, compared to the lack of Polη alone. In conclusion, we propose that Polι acts as a bona fide backup for Polη in the TLS of UV‐photoproducts.
Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis
Authors: Kim So‐Hee , Lee Se‐Hwa , Park Tae‐Ki , Tian Yanchen , Yu Kyoungjae , Lee Byeong‐ha , Bai Ming‐Yi , Cho Sung‐Jin , Kim Tae‐Wuk 
Published: November 2023

SUMMARYBrassinazole Resistant 1 (BZR1) and bri1 EMS Suppressor 1 (BES1) are key transcription factors that mediate brassinosteroid (BR)‐responsive gene expression in Arabidopsis. The BZR1/BES1 family is composed of BZR1, BES1, and four BES1/BZR1 homologs (BEH1–BEH4). However, little is known about whether BEHs are regulated by BR signaling in the same way as BZR1 and BES1. We comparatively analyzed the functional characteristics of six BZR1/BES1 family members and their regulatory mechanisms in BR signaling using genetic and biochemical analyses. We also compared their subcellular localizations regulated by the phosphorylation status, interaction with GSK3‐like kinases, and heterodimeric combination. We found that all BZR1/BES1 family members restored the phenotypic defects of bri1‐5 by their overexpression. Unexpectedly, BEH2‐overexpressing plants showed the most distinct phenotype with enhanced BR responses. RNA‐Seq analysis indicated that overexpression of both BZR1 and BEH2 regulates BR‐responsive gene expression, but BEH2 has a much greater proportion of BR‐independent gene expression than BZR1. Unlike BZR1 and BES1, the BR‐regulated subcellular translocation of the four BEHs was not tightly correlated with their phosphorylation status. Notably, BEH1 and BEH2 are predominantly localized in the nucleus, which induces the nuclear accumulation of other BZR1/BES1 family proteins through heterodimerization. Altogether, our comparative analyses suggest that BEH1 and BEH2 play an important role in the functional interaction between BZR1/BES1 family transcription factors.
Peroxisome population control by phosphoinositide signaling at the endoplasmic reticulum‐plasma membrane interface
Authors: Knoblach Barbara , Rachubinski Richard A. 
Published: November 2023

AbstractPhosphoinositides are lipid signaling molecules acting at the interface of membranes and the cytosol to regulate membrane trafficking, lipid transport and responses to extracellular stimuli. Peroxisomes are multicopy organelles that are highly responsive to changes in metabolic and environmental conditions. In yeast, peroxisomes are tethered to the cell cortex at defined focal structures containing the peroxisome inheritance protein, Inp1p. We investigated the potential impact of changes in cortical phosphoinositide levels on the peroxisome compartment of the yeast cell. Here we show that the phosphoinositide, phosphatidylinositol‐4‐phosphate (PI4P), found at the junction of the cortical endoplasmic reticulum and plasma membrane (cER‐PM) acts to regulate the cell's peroxisome population. In cells lacking a cER‐PM tether or the enzymatic activity of the lipid phosphatase Sac1p, cortical PI4P is elevated, peroxisome numbers and motility are increased, and peroxisomes are no longer firmly tethered to Inp1p‐containing foci. Reattachment of the cER to the PM through an artificial ER‐PM “staple” in cells lacking the cER‐PM tether does not restore peroxisome populations to the wild‐type condition, demonstrating that integrity of PI4P signaling at the cell cortex is required for peroxisome homeostasis.
Computation of Stagnation Point Convection Flow of Carbon Nanotube Nanofluids From a Stretching Sheet With Melting: Dual Solutions
Authors: Rubel M. Rifat Hasan , Ferdows M. , Tazin Tahia , Bég T. A. , Anwar Bég O. , Kadir Ali 
Published: November 2023

Abstract
A theoretical study in stagnation point flow is presented where melting heat transfer effects of carbon nanotube (CNT) from a stretching surface is appeared. Both carbon nanotubes like single-wall CNT (SWCNT) and multiwall CNT (MWCNT) are homogeneously dispersed in the base fluid. As the ordinary (or base) fluids, water and kerosene oil are employed. A set of nonlinear ordinary differential equations with appropriate boundary conditions is formed by transforming the governing equations via similarity transformations. The transformed nonlinear ordinary differential equations are then solved numerically using the bvp4c solver in matlab, an efficient numerical finite difference method. The impact of nanoparticle volume fraction, velocity, melting, stretching parameter, and CNT type on transport characteristics are explored and visualized graphically and in tabular forms. Verification of the matlab computations with available data in certain limiting cases is included showing excellent agreement. Existence of dual (upper and lower branch) solution is shown for a certain range of stretching sheet parameter. The obtained dual solutions are examined for velocity and temperature in detail. A stability analysis demonstrates that the first solution is a stable solution, and the second solution is an unstable solution. Local skin friction and local Nusselt number are also computed in order to determine critical values that can permit dual solutions. It is observed that when a dimensionless melting parameter is greater than 1, SWCNT nanofluids attain greater velocities than MWCNT nanofluids for water as well as kerosene oil base fluids. Moreover, the flow is accelerated for SWCNT compared with MWCNT for both water and kerosene oil. With increasing stretching parameter, the heat transfer rate (Nusselt number) increases, whereas skin friction coefficients decrease. Higher skin friction and Nusselt number are obtained for SWCNTs compared to MWCNTs due to their greater density and thermal conductivity. The study is relevant to phase change manufacturing fluid dynamics of nanomaterials.
High-Intensity Forward-Backward Plyometrics After the Warm-Up Entail Better Sprint and Change-of-Direction Performance Than Low-Intensity Side-to-Side Plyometrics
Authors: Ben Ayed Karim , Hammami Raouf , Gene-Morales Javier , Ajailia Amira , Werfelli Hanen , Rebai Haithem , Jiménez-Martínez Pablo , Flandez Jorge , Colado Juan C. 
Published: November 2023

This study aimed to determine the acute effects of high-intensity forward-backward and low-intensity side-to-side plyometric jumps performed following the warm-up on sprint (5, 10, and 15 m) and change-of-direction (COD) (T-half test and repeated T-half tests) performance in youth volleyball players. After a familiarization week, 30 male volleyball players (age = 12.04 ± 1.03 years) performed three randomized conditions (no-plyometrics, high-intensity plyometrics, and low-intensity plyometrics) in three sessions. In a within-subject design, three sets of six repetitions of forward-backward 30-cm hurdle jumps (high-intensity) and side-to-side 20-cm hurdle jumps (low-intensity) were completed. Sprint and COD were tested after each of the conditions with a 2-min rest. A significant effect of the plyometric condition was observed on sprint (p < .001, range: .56–.70) and COD (p < .01, ), but not on repeated COD. More specifically, the high-intensity plyometric condition exhibited significantly better results compared with the low-intensity plyometric (Cohen’s d range: 0.73–1.21) and control conditions (Cohen’s d range: 0.91–2.21). Due to the importance of speed and COD in volleyball, these results suggest that young volleyball players may benefit from high-intensity forward-backward plyometric protocols following the warm-up to improve subsequent performance.
Assessing the potential for healthier consumer food substitutions in Canada: population-level differences in dietary intakes of whole grains, refined grains, red meats, and legumes
Authors: Luongo Gabriella , Jago Emily , Mah Catherine L. 
Published: November 2023

The potential for healthier consumer food substitutions is an important factor in the study of food environments, dietary choices, and population nutrition promotion. The burden of diet-related non-communicable diseases is unevenly distributed across Canada and variation in the food environment sub-nationally may be an important explanation. We used population-based 24 h dietary recall data from the 2015 Canadian Community Health Survey—Nutrition for Canadian adults ( n = 13 919) to examine dietary intakes of two food group pairings (whole grains/refined grains and legumes/red meats) where consumer substitutions have been recognized to be of importance in promoting healthy and sustainable population diet. We used an ANOVA followed by pairwise comparisons with Bonferroni correction to estimate differences in intakes between provinces for daily weight and proportion of total energy consumed. Based on the Global Burden of Disease Study, Canadians consumed below the average daily requirements of legumes and whole grains and well above the required range of red meat, suggesting room for broad improvements to population diet. Findings also demonstrate that there is potential for targeted shifts in dietary intakes among non-consumers of certain foods (e.g., legumes). This study may inform intervention development for the consumer nutrition environment including food accessibility and affordability to reduce non-communicable disease risk.