bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the suitability of 6-oxo-PIP as a novel biomarker for pyridoxine-dependent epilepsy in multiple samples
Authors: Jiao Xianru , Gong Pan , Niu Yue , Xu Zhao , Zhou Zongpu , Qin Jiong , Yang Zhixian 
Published: January 2024

Abstract
Objective
To evaluate the suitability of 6-oxo-PIP as a possible new biomarker for PDE-ALDH7A1, and to compare it with α-AASA-P6C, PA, and α-AAA.
Methods
The biomarkers of 12 PDE-ALDH7A1 patients and age-matched epilepsy control patients were quantitatively assayed by LC-MS/MS. Four types of samples were prepared, including plasma, dried blood spots (DBS), urine, and dried urine spots (DUS).
Results
In PDE-ALDH7A1 group, the values of α-AASA-P6C and 6-oxo-PIP were above the reference range, while α-AAA and PA could be normal or slightly elevated. The concentration ranges of PA and α-AAA overlapped partially between PDE-ALDH7A1 group and epilepsy group in all specimens, while α-AASA-P6C and 6-oxo-PIP did not overlap between the two groups. A positive correlation between plasma and DBS, or urine and DUS of 6-oxo-PIP was found, and the level of 6-oxo-PIP in urine and DUS was much higher than other types of samples. Although the values of α-AASA-P6C was positively correlated in plasma and DBS or urine and DUS, the difference between plasma and DBS was significant. The concentrations of PA and α-AAA were positively correlated only in plasma and DBS or urine and DUS, respectively. Regardless of storage temperature, the concentrations of 6-oxo-PIP were above 95% of the initial value after 28 days in all specimens.
Conclusions
In PDE-ALDH7A1, 6-oxo-PIP was specific when compared with other epilepsy patients even under pyridoxine treatment. 6-oxo-PIP could be prepared into DUS for detection, making it possible for non-invasive screening of PDE. Regardless of sample type, 6-oxo-PIP is relatively stable at RT.
Unexpected disappearance of lower limb deep venous thrombosis in an elderly patient following fracture: a case report
Authors: Duan Wenyu , Liang Hao , Wang Yunxia , Fan Xiaolong , Wang Yulu , Zhou Dongming , Zhang Haidong 
Published: January 2024

Abstract
The older patients with intertrochanteric fractures often develop lower limb deep venous thrombosis after bed rest, which not only seriously affects their treatment, but also increases the expensive cost of treatment. Here, we describe an 84-year-old female with a history of significant hypertension and diabetes. Following injury, she was admitted to the hospital and underwent a series of laboratory tests, including X-ray examination. She was hospitalized for a right intertrochanteric fracture and prepared for surgical treatment, but developed deep vein thrombosis in the lower limb 2 days after admission. This case emphasizes the importance of low molecular weight heparin calcium anticoagulant therapy after lower limb deep vein thrombosis occurs.
Remote Sensing Image Information Extraction Based on Compensated Fuzzy Neural Network and big data analytics
Authors: Sun Rui , Zhang Zhengyin , Liu Yajun , Niu Xiaohang , Yuan Jie 
Published: January 2024

Abstract
Medical imaging AI systems and big data analytics have attracted much attention from researchers of industry and academia. The application of medical imaging AI systems and big data analytics play an important role in the technology of content based remote sensing (CBRS) development. Environmental data, information, and analysis have been produced promptly using remote sensing (RS). The method for creating a useful digital map from an image data set is called image information extraction. Image information extraction depends on target recognition (shape and color). For low-level image attributes like texture, Classifier-based Retrieval(CR) techniques are ineffective since they categorize the input images and only return images from the determined classes of RS. The issues mentioned earlier cannot be handled by the existing expertise based on a keyword/metadata remote sensing data service model. To get over these restrictions, Fuzzy Class Membership-based Image Extraction (FCMIE), a technology developed for Content-Based Remote Sensing (CBRS), is suggested. There are four steps in the proposed idea. First, a Compensated Fuzzy Neural Network(CFNN) is used to compute the class label and fuzzy class membership of the query image. The Retrieval is carried out in the second stage, utilizing an essential and balanced weighted distance metric. Third, Feature Information Extraction (FIE) is based on time-frequency implications to enhance RS image handling and autonomous information retrieval of visual contents like an image's color, texture, and shape attributes. Fourth, a quicker query is produced at search time thanks to the hierarchically nested structures and recurrent similarity measures. The experiment's findings indicate that applying the proposed model can have favorable outcomes for assessment measures, including Ratio of Coverage, average means precision, recall, and efficiency retrieval that are attained more effectively than the existing CR model. In the areas of feature tracking, climate forecasting, background noise reduction, and simulating nonlinear functional behaviors, CFNN has a wide range of RS applications. The work provides an important application guidance to medical imaging AI systems and big data analytics.
Distinctive Inflammasome Response to Hymenoptera Venoms in Allergic Individuals
Authors: SM Yamada , LO Mendonça , BP Eleuterio , RAG Cambui , MGV Roa , LAT Oliveira , PLM Castro , AS Watanabe , FFM Castro , Pontillo Alessandra 
Published: January 2024

Abstract
Allergic reactions to venom from Hymenoptera insects, such as bees, wasps, and "fire" ants, are relatively common in Brazil, comprising 5-7.5% of all cases of life-threatening anaphylaxis. This study aimed to characterize the activation of the inflammasome in individuals allergic to Hymenoptera venom, considering the established role of the NLRP3 inflammasome in responding to bee venom. We hypothesized that inflammasome activation might be dysregulated in allergic individuals, to this end, inflammasome activation in monocyte-derived macrophages (MDM) isolated from allergic individuals in response to bee, wasp, or "fire" ant venom was evaluated. The MDM of allergic patients displayed heightened responsiveness to the stimuli in comparison to non-allergic individuals, both in terms of IL-1ß release and the rate of pyroptosis. These findings suggest that a pro-inflammatory background could influence the allergic reaction to insect venom in addition to the IgE-related response.
The Modified Retroperitoneal Laparoscopic Adrenalectomy effectively resolves adhesive periadrenal fat and achieves superior outcomes
Authors: Hu Minxiong , Li Aiqing , Cai Wenchao , Xu Xiao , Cai Wanghai , Pan Honghong , Yang Zesong , Wu Jinfeng , Zhu Qingguo , Ye Liefu 
Published: January 2024

Abstract

Purpose: The Mayo adhesive probabilityscore affects adrenalectomy outcome. To determine whether modified three-layered retroperitoneal laparoscopic adrenalectomy overcomes periadrenal fat adhesion compared to classic three-layered retroperitoneal laparoscopic adrenalectomy to achieve better surgical outcomes.
Materials and Methods: Patients who underwent retroperitoneal laparoscopic adrenalectomy were divided into two groups from January 2016 to December 2022. Baseline characteristics and perioperative data were analyzed, and statistical significance was defined as p<0.05. Linear regression analysis was used for data that met certain conditions, such as linearity, normality, and independence. Binary logistic regression analysis was employed for binary classification of the dependent variables.
Results: A total of 731 patients underwent retroperitoneal laparoscopic adrenalectomy, and 651 patients had adequate data for the adhesive probability score assessment. Of these patients, 247 were in the modified group and 404 were in the classic group, and baseline characteristics were comparable between the two groups (p>0.05). The modified group exhibited superior outcomes in terms of the operating time, duration, postoperative hospital stay, estimated blood loss, and complications. Notably, there were 16 cases of unplanned adrenalectomy in the classic group, whereas no such cases occurred in the modified group. Further analysis revealed that periadrenal stranding may be the underlying cause of this discrepancy.
Conclusions: The modified three-layered retroperitoneal laparoscopic adrenalectomy effectively overcame the impact of adhesive periadrenal fat compared with the classic approach. We recommend the use of modified three-layered retroperitoneal laparoscopic adrenalectomy for patients with adhesive periadrenal fat.
Application of a customized 3D-printed osteotomy guide plate for tibial transverse transport
Authors: Wei Dongxuan , Huang Jiahui , Zhou Xianglong , Song Hui , Xiong Liming 
Published: January 2024

Abstract

Objective Enhance the efficiency of tibial transverse transport by employing customized 3D-printed osteotomy guide plates and striving to improve precision through CT evaluation for enhanced guide design.
Methods 17 diabetic foot patients were treated with the plate for tibial transverse transport. Preoperatively, we collected DICOM data from the affected tibia's CT and designed the geometric parameters of the tibial cortical bone window. A customized 3D-printed osteotomy guide plate was then fabricated using 3D printing technology. Postoperative X-ray and CT evaluations, conducted at two and five weeks post-surgery, assessed five crucial geometric parameters of the bone window. Measurements included the distance from the upper edge of the tibial cortical bone window to the tibial plateau, the distance from the anterior edge of the tibial cortical bone window to the bone ridge, the height of the tibial cortical bone window, the center-to-center distance between the 4.0mm diameter Schanz pin and the osteotomy Kirschner pin, and the center-to-center distance of the 4.0mm diameter Schanz pin. These measured parameters were subsequently compared to the preoperative design parameters.
Results CT measurements showed no significant differences (P > 0.05) from preoperative design parameters across the five evaluated aspects. The average osteotomy duration was 35 ± 15 minutes with no bone window fractures. The bone window aligned effectively with the tibial shaft, achieving complete incorporation after distraction. A 4 to 8-month postoperative follow-up confirmed full healing of the tibial surgical wound and diabetic foot wounds.
Conclusion Utilizing customized 3D-printed osteotomy guide plates in tibial transverse bone transport surgery enables accurate translation of preoperative virtual designs into real-time procedures, enhancing surgical efficiency and quality.
PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickens
Authors: Wei Hong-Jiang , Kinoshita Keiji , Tanabe Kumiko , Nakamura Yoshiaki , Nishijima Ken-Ichi , Suzuki Takayuki , Suzuki Takayuki , Mizushima Shusei , Wang Ming-Shan , Khan Sami , Xu Kaixiang , Jamal Muhammad , Wei Taiyun , Zhao Heng , Su Yanhua , Sun Feizhou , Liu Gang , Zhu Fangxian , Zhao Hongye 
Published: January 2024

Abstract
Primordial germ cells (PGCs) are essential precursors for sperm and eggs. PGCs are highly reliable for conserving chicken germplasm and producing genetically modified chickens. Currently, efforts to conserve native chicken germplasm through PGCs and research on genetically modified chickens using CRISPR/Cas9 are limited. In this study, we successfully established 289 PGC lines from eight Chinese chicken populations with an 81.6% derivation rate. Furthermore, we successfully regenerated Piao chickens derived from these PGCs by repropagating cryopreserved PGCs and transplanting them into recipient chickens, resulting in a 12.7% efficiency rate. The regenerated chickens carried mitochondrial DNA from the female PGC donor and the rumplessness (Rp) mutation from male and female PGC donors in a homozygous condition. As a further application, we utilized CRISPR/Cas9 genome editing to disrupt the TYRP1 gene and created KO PGC lines. Transplanting KO cells into male recipients and mating them with wild-type hens enabled the successful generation of four TYRP1 KO chickens. Molecular analysis confirmed a 73 bp deletion in these four chicks, resulting in a frameshift mutation in the TYRP1 target region. These KO chickens had brown plumage due to reduced eumelanin production, observed in both homozygous and hemizygous mutations, compared to wild-type chickens. In conclusion, we have efficiently cultured and cryopreserved chicken PGCs, used them to regenerate chickens, and generated gene-edited chickens with TYRP1 dysfunction. These achievements will greatly impact the conservation of chicken genetic diversity, create new mutation models, and have potential applications in biomedical and avian research and breeding advancements.
Research on infrastructure scale structure misallocation under economic and low-carbon perspectives: evidence from China's toll expressway industry
Authors: Bai Pengrui , Ma Zhiyu 
Published: January 2024

Abstract
Improving resource allocation efficiency is an important way to promote the high-quality and low-carbon development of toll expressways. This paper constructs a resource misallocation measurement model with the demand of the economic, low-carbon and comprehensive of toll expressway construction in each region, and adopts the panel data of 26 provinces from 2013 to 2021 to measure the scale allocation gap of toll expressways under different demands, and analyzes the inter-regional and supply-demand imbalance. The results show that: the current network layout of toll expressways lacks sufficient balance, manifesting in varying degrees of mileage and capital allocation across different regions; Resource allocation of toll expressways tends to outflow from over-resourced regions with high connectivity, while simultaneously inflow to under-resourced, low connectivity areas; Regions have commenced positioning the enhancement of environmental protection capabilities of toll expressways and the expansion of their economic benefits at an equivalent strategic echelon; The national policy plays a significant role in enhancing the overall efficiency of expressway resource allocation. The conclusions of this study provide policy insights for the optimization of resource allocation in China's toll expressways, particularly in terms of driving high-quality development and narrowing the gap between supply and demand.
Prevalence and Factors Associated with Caesarean section among Tanzanian women of reproductive age: Evidence from the 2022 Tanzania Demographic and Health Survey Data
Authors: Nahayo Bonfils , Ndayishimye Samuel , Olorunfemi Gbenga , Nsanzabera Charles 
Published: January 2024

Abstract
Background
Caesarean section is one of the commonest surgical procedures worldwide. It is an important medical intervention for reducing the risk of poor perinatal outcomes. However, trends in caesarean section in sub-Saharan Africa continue to increase, while maternal and neonatal mortality and morbidity remain high. This study aims to determine the prevalence and factors associated with caesarean section in Tanzania.
Methodology
This was a secondary data analysis of 4,768 women of reproductive age (15-49) in Tanzania. The data utilized was from the Tanzania Demographic Health and Survey (TDHS) 2022. The factors associated with caesarean section were identified using multivariable binary logistic regression.
Results
Out of 4,768 women of reproductive age in Tanzania, 497 (10.4%) underwent a cesarean section. Attained primary (aOR: 1.79 ,95% CI 1.23-2.60), secondary (aOR:2.07,95% CI 1.36-3.14) and higher education (aOR: 2.35, 95% CI 1.08-5.12) or having a husband/partner with higher education ,being in richer household wealth quintile (aOR:1.98 ,95% CI (1.31-3.00) or in the middle (aOR :1.91 ,95% CI (1.28-2.85), having a job (aOR : 1.29, 95% CI: 1.05-1.58)and attended more than 4ANC(aOR: 1.36, 95% CI: 1.11-1.67) were associated with a higher odds of undergoing caesarean section compared to their respective counterparts. However, living in rural areas (aOR: 0.74, 95% CI:0.58- 0.94), being multiparous women with 2-4 births (aOR: 0.67, 95% CI: 0.53-0.84) and 5 and more births (aOR: 0.44, 95% CI: 0.32-0.60) were associated with lower odds of caesarean section.
Conclusion
The overall prevalence of caesarean section among women of reproductive age in Tanzania was 10.4%. The highest educational level, husband/partner's education level, household wealth quintile, type of residence, employment status, increased ANC number, and high parity were associated with caesarean section. There is an urgent need for continued efforts to ensure universal access to essential critical care services for all populations, thereby preventing premature maternal and infant mortality.
Built-in Sensor Based Spindle Radial Error Motion Separation Method for Cutting Conditions
Authors: xu xinping , Tao Tao , Mei Xuesong , Jiang Gedong , Geng Tao 
Published: January 2024

Abstract
This study focuses on the development of a spindle radial error motion separation method that can realize on-line measurement in the cutting state of the machine tool. Measuring the radial error motion of the spindle in the cutting process is an important basis for monitoring the machining quality of the workpiece and analyzing the dynamic characteristics of the spindle. The problems encountered in the application of traditional methods under cutting conditions, such as inaccurate data interception, angle non-uniformity of sampling data and installation angle error, are simulated and analyzed. An on-line measurement method based on the built-in encoder signal of the spindle is proposed. The angle signal of the spindle encoder is obtained synchronously by the built-in sensor acquisition technology of the CNC machine tool as the reference for data interception and calculation. The equal angle interval resampling method is constructed to convert the equal time interval data into the equal angle interval data, and the influence of the angle non-uniformity of the data on the measurement is weakened. The simulation comparison shows that the proposed method can effectively solve the problems existing in the measurement under cutting conditions. Finally, an actual cutting experiment is carried out to verify the effectiveness of the proposed method, and it is shown that the proposed method can obtain higher measurement accuracy than the traditional three-point method under cutting conditions.
A Study on Observer Design for a Class of Nonlinear Systems using Lyapunov Stability
Authors: Taran Babak , Taran Behnam 
Published: January 2024

Abstract
This research proposes a novel Lyapunov-based method for designing an observer for a class of nonlinear systems whose unmeasured states appear linearly in the state-space model, while the coefficients can be nonlinear functions of the measured states and time. In the other words equations can be express as a Linear Parameter-Varying (LPV) systems in which the parameter-dependent matrices depend on time and accessible variables. Many papers that deal with developing an observer for LPV systems assume that the variable parts are bounded for the feasibility of the design. By extending the conventional method which is used to estimate the state variables in linear systems, this study introduces an innovative scheme that has no limitations on the scheduling parameters. In the error equations, which quantify the discrepancy between the actual system and the estimated system, the matrices dependent on scheduling parameters can exhibit stable eigenvalues, provided that the observer gain matrix is selected appropriately. This matrix should be a continuous function. The stability of the eigenvalues implies that the observer can accurately estimate the state variables, as shown by using Lyapunov stability analysis.
Mathematics Subject Classification
34D20 58E25
On the Mechanisms that Control the Rainy Season Transition Period in the Southern Congo Basin
Authors: Worden Sarah , Fu Rong 
Published: January 2024

Abstract
The Congo basin hosts one of the largest terrestrial precipitation centers. Yet, the mechanisms that start the rainy seasons in Congo have not been studied systematically. We show that the transition from the dry to the rainy season over the southern Congo is initiated by a decrease in moisture export towards the Sahel, about three to four months before the rainy season onset (RSO), referred to as the pre-transition period. During this period, evapotranspiration (ET) is low due to low surface solar radiation, resulting from low insolation, and high amounts of low-level clouds. In the early transition period one to three months before the RSO, column water vapor and surface specific humidity increase due to increased oceanic moisture. Meanwhile, ET starts increasing for the first time due to increases in surface radiation and vegetation photosynthesis, despite a lack of soil moisture increases. Finally, in the late transition period about one month before the RSO, ET continues to increase, contributing equally to atmospheric moisture needed for deep convection as advected oceanic moisture. Additionally, the formation of the African Easterly-Jet South and the southward movement of the Congo Air Boundary increase vertical wind shear and provide large-scale dynamic lifting of the warm and humid air from the Congo. The frequency of deep convection increases rapidly, leading to the start of the rainy season. Therefore, the RSO over southern-hemispheric Congo basin is a result of combined large-scale atmospheric circulation change and vegetation response to the seasonal change of insolation.
Evidence of northward dipping crustal layers underneath the eastern part of the Indo- Gangetic foreland basin, India: Implication for geodynamic evolution and seismogenesis
Authors: Chouhan Avinash Kumar , Kumar Prakash , Islam Meyarul , Maurya S. P. , Chopra Sumer 
Published: January 2024

Abstract

The continual collision and convergence of two plates, the Indian and the Eurasian plates, of extensively different crustal thicknesses, created one of the most dynamic geological provinces in the northern part of the Indian subcontinent, the Indo-Gangetic foreland basin (IGFB). The crustal geometry in this part of the Indian plate has remained the prime focus of many researchers due to the occurrence of devastating earthquakes. In this context, we complement previous works and aim to map the crustal layers to make a realistic and most acceptable premise for tectonogenesis of the eastern IGFB. The derivative analysis of the Bouguer anomaly delineates the east-west trending basement-controlled subsurface geological structures related to the Miocene and Pleistocene epochs. The results of our study inferred that the Precambrian basement and Moho depth varies between 1 to 6.8 km and 39 to 60 km, respectively. The forward modelling of the Bouguer anomaly reveals that the crustal interfaces beneath the eastern IGFB are sharply dipping toward the north direction, primarily associated with the Himalayan orogeny of the Miocene and Pleistocene epochs. The findings of this study suggest that the Munger-Saharsa ridge controls subsidence in this part of the IGFB from the Miocene epoch to the present. Moreover, the study has also identified a blind fault in the Gandak depression, and its rapport with seismicity in the region is discussed. We have argued that the Munger-Saharsa ridge and the crustal bending mainly influence the seismicity in the eastern part of the IGFB.