bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE DEVELOPMENT OF RELOAD-C, A WEB-BASED PLATFORM TO REDUCE LONELINESS IN CAREGIVERS OF PERSONS WITH ADRD
Authors: Marziliano Allison , Applebaum Allison , Burns Edith , Gieniusz Marzena , Mongelli Jessica , Patel Priya , Babar Huma , Diefenbach Michael 
Published: December 2023

Abstract
There is a need for effective evidence-based interventions to reduce loneliness in caregivers of persons with Alzheimer’s Disease and Related Dementias (ADRD). Interventions to reduce loneliness may be strengthened by incorporating concepts from Meaning-Centered Psychotherapy (MCP), effective in increasing meaning in life in patients with advanced cancer and their caregivers. Our central hypothesis is that concepts from MCP can be adapted for caregivers of persons with ADRD to reduce their loneliness through increasing their sense of meaning and purpose in life. Our purpose is to describe the development of RELOAD-C (REducing LOneliness in Alzeheimer’s Disease-Caregivers), a web-based platform that delivers MCP concepts, adapted for ADRD caregivers, via 6 brief videos, 7 virtual peer group meetings, and written content. The development of RELOAD-C occurred in 3 stages: 1) Preparatory Work/Adaptation of scripts from 6 existing MCP videos. 2) Stakeholder Involvement. N=15 AD/ADRD caregivers underwent individual interviews to provide expert feedback on the scripts. 3) Development of RELOAD-C. In collaboration with web specialists, RELOAD-C is created by integrating adapted MCP videos, links to virtual peer groups to discuss MCP concepts, and written MCP content. Input from stakeholders indicated: 1) preference for terminology (e.g., “caregiver” over “care partner”); 2) removing MCP content that urges caregivers to engage in complex conversations with the care recipient; 3) providing an explanation of ambiguous concepts (e.g., “unfinished business”); and 4) re-ordering the delivery of the MCP concepts. RELOAD-C is the product of multiple rounds of review by a multidisciplinary team and ADRD caregivers as expert stakeholders.
NOBODY CAN DRAG ME DOWN: AGING AS A DRAG PERFORMER
Authors: Donorfio Laura , Henneberry Kathleen , Chapman Brian 
Published: December 2023

Abstract
This presentation will detail the findings of an exploratory, qualitative research study examining the intersection of aging and drag performance. Even though drag queens have achieved significant levels of visibility in mainstream entertainment and have become increasingly present topics of discussion in news outlets, modern media, and even political landscapes, they are an understudied and underrepresented population (Knutson et al., 2020; O’Brien, 2018). Older drag queens have yet to be studied in the social science literature (Henneberry et al., 2022). “Drag Queens possess unique characteristics as a subpopulation of the lesbian, gay, bisexual, and transgender (LGBT) community that warrant exploration” (Knutson, Koch, Sneed, & Lee, 2018). This research aims to understand and represent the relatively understudied population of drag queens in academic literature while drawing attention to the specific sub-population of older adults in the profession. A semi-structured interview protocol and thematic analysis was utilized to understand the unique perspectives of self identified drag performers over the age of 50 (n=15; ages 54-94). Examining drag artistry and expression through the lens of aging has revealed themes of drag as a form of armor, ageism within the community, and shifts in social perceptions of drag performers. This presentation will introduce the term “dragism” in an attempt to explain the discrimination against drag queens within the LGBTQ+ community, as well as the interplay of both dragism and ageism for the participants of this study (Donorfio et al., 2022).
AGE AND STRESSOR-RELATED NEGATIVE AFFECT IN OLDER ADULTS: CROSS-SECTIONAL AND LONGITUDINAL EVIDENCE
Authors: Ferguson Giselle , Zavala Daisy , Corley Samantha , Scott Stacey 
Published: December 2023

Abstract
Most daily stress studies show stressor-related increases in Negative affect (NA), but older adults may show smaller increases due to emotion-regulation skills. However, most of this work is based upon single burst diary or ecological momentary assessment (EMA) studies which are functionally cross-sectional age comparisons; longitudinal analyses are needed to reveal whether individuals change as they age. In this secondary analysis of data from a measurement burst study of older adults in Bronx, NY (N=305; Mage=76.98), we examined how age interacted cross-sectionally and longitudinally with the effect of stressors on NA. Between 2017- (pre-pandemic) 2020, participants completed up to three 14-day EMA bursts. Five times daily, they reported current NA and whether a stressor had occurred since the last assessment. In a 4-level multilevel model accounting for demographics, Neuroticism, and stressors, NA was significantly higher with reports of stressors, including at the moment-level, day-level, and person-level. Regarding aging’s role in average NA for non-stressor moments, there were not significant cross-sectional age differences, but longitudinally across three bursts, NA increased significantly within-persons. We did not find evidence for cross-sectional age differences nor longitudinal change in the stressor-NA slope. Although neither cross-sectional age differences nor longitudinal change was found in the stressor-NA slope, we found significant longitudinal increases in non-stressor NA as individuals aged. Our results illustrate the value of measurement burst designs for disentangling differences between cross-sectional and longitudinal effects in daily processes. Further research on aging-related differences in affect and stress would benefit from these approaches.
DAILY EMOTION REGULATION AND AFFECT ACROSS WORK AND FAMILY CONTEXTS IN MID LIFE
Authors: Nichols Madeline , Chandler Kelly 
Published: December 2023

Abstract
Emotion regulation is an important skill for adults to use in interpersonal situations; however, limited research has examined whether emotion regulation strategies vary by context or the potential influences these strategies have on daily affect. We examined the frequency of emotion regulation strategies used in work and family contexts and the extent to which these strategies predicted daily positive and negative affect (PA; NA). Middle-aged adults (N=27, Mage=60.15, SD=3.77; Female=91.67%) completed 7 daily diary surveys. In both contexts, adults most often reported modifying situations to be more positive and using situational approaches. At work, adults also frequently expressed their emotions; at home, they reported modifying situations to be less negative. Preliminary multilevel model results indicated that NA was significantly higher on days when individuals reported distracting themselves from work situations (Est.=7.36, p&lt;.01), suppressing emotions at work (Est.=3.29, p&lt;.01), or expressing emotions around family (Est.=4.41, p&lt;.01) compared to days when they did not use these strategies; conversely, on days when individuals distracted themselves from family situations, they reported lower NA (Est. =-2.80, p=.03) than on days they did not. On average, people who modify family situations to be more positive report higher PA (Est.=6.73, p&lt;.01) than those who do not. Our results suggest that there is daily variability in emotion regulation strategy use and consequential impacts on affectual wellbeing by context. Understanding which emotion regulation strategies yield the most benefit in different contexts may inform interventions targeting emotion regulation as a modifiable behavior to promote health and wellbeing in later life.
SELF-RATINGS OF HEALTH BY AGE AND BIRTH COHORT: FOR WHOM DO THEY PREDICT MORTALITY?
Authors: Idler Ellen , Dore Emily 
Published: December 2023

Abstract
Global self-rated health as a predictor of mortality has become one of the most reliable outcomes in population-based follow-up studies. However, few studies focus on age or birth cohort differences in the mortality predictiveness of self-ratings of health. Personal knowledge of health accumulates throughout the life course, leading to the hypothesis that self-rated health would be most predictive in old age or in earlier birth cohorts. However, the pronounced effect of self-rated health on mortality means that those with the higher mortality risk of poor self-rated health in earlier adulthood would be less likely to survive to old age, potentially diminishing the effect through selective survival. In this paper we test for potential variations in the effects of age and birth cohort on the association between self-rated health and mortality in a large sample of adults aged 25-101 in the Panel Study of Income Dynamics (N=6437) followed from 1999-2019. We ask if self-rated health -- net of sociodemographic factors, physical and mental health conditions, and health risk behaviors – is equally predictive of mortality in three age groups spanning young, middle, and late adulthood, and in four birth cohorts. Fully adjusted models show that self-rated health was the most predictive for the group aged 41-64, and for those born 1946-1980, and that there were nearly null effects for those aged 25-40 or born 1981-1994. Thus, the effects of self-rated health on mortality vary by age and cohort, in ways that support both knowledge-based and selective survival interpretations of the association.
DEMYSTIFYING IMPACTS OF NEIGHBORHOOD ENVIRONMENT ON HEALTH OF OLDER CHINESE AMERICANS
Authors: Jiang Yanping , Tang Fengyan 
Published: December 2023

Abstract
Residential segregation is a key social determinant of health that disproportionately affects racial/ethnic minority and immigrant populations. The health impact of residential segregation and subjective neighborhood environment, however, is poorly understood among older Asian Americans. Findings from the limited existing studies on this topic exclusively relied on cross-sectional data and/or masked distinctive differences across Asian subgroups due to the usage of aggregated data. The purpose of this symposium is to provide a better understanding of health impacts of residential segregation and subjective neighborhood environment among older Chinese Americans, the largest Asian subgroup in the U.S. Findings presented in this symposium were from the Population Study of Chinese Elderly in Chicago (PINE) study, a longitudinal study of community-dwelling older Chinese immigrants living in greater Chicago. Session 1 describes key characteristics of neighborhood, sociodemographic, and health behaviors of older Chinese immigrants living in segregated neighborhoods. Session 2 moves beyond to determine unique and joint effects of residential segregation and neighborhood socioeconomic status on 8-year change in cognitive functioning. Session 3 focuses on mental health by investigating main and indirect effects of residential segregation on depression via social processes. Session 4 tests the interactive effects of social support with residential segregation on cognitive functioning and depression. Lastly, Session 5 demonstrates how subjective neighborhood environment, directly and indirectly, affects depression via coping. In sum, findings provide innovative and important evidence to facilitate a better understanding of health implications of living in segregated neighborhoods among older Chinese Americans.
PATIENT PRIORITIES CARE: THE PAST, THE PRESENT, AND THE FUTURE
Authors: Naik Aanand 
Published: December 2023

Abstract
Healthcare based on patient goals can improve the care of older adults, particularly those with MCC. Prior studies have identified five healthcare values that guide how patients establish healthcare goals and make medical decisions: 1) Self-sufficiency, 2) Enjoyment, 3) Connection, 4) Balancing quality and length of life, 5) Engagement in care. The Patient Priorities Care (PPC) approach is an evidence-based approach that allows patients to identify their healthcare values, or what matters most to them, and identify one thing, the most important goal they want to address based on their healthcare preferences. We have demonstrated that PPC is feasible and results in less burdensome care, including fewer medications and referrals to specialists. In the VA system, we have also shown that PPC helps clinicians recommend home and community services that are aligned with the patient’s priorities. To enhance its relevance for Veterans, African Americans, and Hispanics, a deliberate effort to adapt PPC has been used at different institutions. We believe that evidence-based interventions like PPC can help address health disparities by: 1) improving communication between healthcare providers and patients with different beliefs, race, ethnicity, and culture; and 2) aligning prevention and timely treatment with the health priorities of older adults with MCC. We will review what we have learned from PPC thus far. We will then describe current efforts to implement PPC in a more effective and sustainable manner and disseminate it in diverse healthcare systems. Finally, we will share our vision moving forward and opportunities for collaboration and growth.
FORMATIVE EVALUATION TRIAL OF THE “MY HEALTH PRIORITIES” PROGRAM IN SOUTHERN OLDER AFRICAN AMERICANS: THE BHIP STUDY
Authors: Ejem Deborah 
Published: December 2023

Abstract
Older African Americans (AA) with multiple chronic conditions (MCCs) living in the Deep South are less likely to have access to early palliative care (PC) despite experiencing higher symptom burden and healthcare use, and poorer communication around goals of care. This disparity in PC use may partly be due to a lack of culturally-responsive care practices that effectively activate AAs with MCCs to identify their own values and priorities for end-of-life care. We conducted a formative evaluation of the web-based, self-directed “My Health Priorities” Identification Program to determine cultural acceptability and feasibility of use among AAs with MCCs in a primary care setting. We are now recruiting 20 AA patient with MCC and caregiver dyads from UAB Kirklin Primary Care Clinic. Recruited dyads will complete the “My Health Priorities” program and participate in semi-structured acceptability interviews. Patients and caregivers will also complete pre- and post-test measures of perception of care, treatment burden, shared decision-making, and communication exchange. Preliminary findings from six dyads suggest that the current program lacks spirituality-specific content. Dyads also expressed that the exemplar character included in the program was not relatable or representative. Overall, participants stated that the program was useful in helping them to think about and articulate their healthcare values and priorities. The findings from the research will directly inform a small-scale pilot grant that will assess the acceptability, feasibility, and potential efficacy of a values solicitation and operationalization intervention for AAs with MCCs and caregivers.
COMPARATIVE TRANSCRIPTOMICS AND PROTEOMICS ACROSS SPECIES
Authors: Gorbunova Vera 
Published: December 2023

Abstract
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species’ maximum lifespan (Neg- or Pos-MLS genes). Neg-MLS genes are pri- marily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. Expression of Neg- and Pos-MLS genes is modulated by interventions, including mTOR and PI3K inhibition. Regulatory networks analysis showed that Neg-MLS genes are under circadian regulation possibly to avoid persistent high expression, whereas Pos-MLS genes are tar- gets of master pluripotency regulators OCT4 and NANOG and are upregulated during somatic cell reprogramming. Pos-MLS genes are highly expressed during embryogenesis but significantly downregulated after birth. This work provides targets for anti-aging interventions by defining pathways correlating with longevity across mammals and uncovering circadian and pluripotency networks as central regulators of longevity. I will also discuss integrating this transcriptome and proteome data.
STRATEGIES OF LIFESPAN REGULATION WITHIN AND ACROSS SPECIES
Authors: Gladyshev Vadim 
Published: December 2023

Abstract
Lifespan varies within and across species, but the general principles of its control remain unclear. We conducted multi-tissue RNA-seq analyses across mammalian species, identifying longevity signatures and examining their relationship with transcriptomic biomarkers of aging and established lifespan-extending interventions. Signatures of long-lived species were positively correlated with age-related changes and enriched for evolutionarily ancient essential genes. Conversely, lifespan-extending interventions counteracted aging patterns and affected younger, mutable genes enriched for energy metabolism. The identified biomarkers revealed new longevity interventions. We further developed a transcriptomic clock that quantifies progression through lifespan and reports the effects of longevity interventions. Overall, this work uncovers universal and distinct strategies of lifespan regulation within and across species and provides tools for quantifying aging and discovering longevity interventions.
IMMUNE AGING AT SINGLE-CELL RESOLUTION
Authors: Artyomov Maxim 
Published: December 2023

Abstract
I will discuss how single-cell resolution approaches reveal aspects of immune aging in tissues and in circulation. We will discuss comparison of immune aging in mouse tissues, accumulation of GZMK+ CD8 T cells and their human counterparts that accumulate in blood. We will discuss analysis of scRNA-seq profiling of PBMC along the healthy aging (317 samples from 25 to 85yo) and emerging subpopulation and antigen receptor changes during aging.
ATLAS-SCALE SINGLE-CELL DATA SCIENCE REVEALS SIGNATURES OF AGING AND REJUVENATION
Authors: Palovics Robert 
Published: December 2023

Abstract
The use of recent high-throughput transcriptomics technologies allows us for the first time to study aging at an unprecedented granularity and temporal resolution. This talk aims to provide insights into aging and heterochronic parabiosis, a model for systemic rejuvenation, by studying an atlas-scale single-cell dataset encompassing &gt;100k cells across 20 organs and 50 cell types in young and aged mice as well as in parabionts. We will explore the age mimicking and age reversing effects of parabiosis within each cell type, identify parabiosis mediated rejuvenation signatures that appear throughout the whole body, and present a structural overview of aging and parabiosis across different organs.
LIVING WELL WITH MILD TO MODERATE DEMENTIA. FINDINGS FROM THE IDEAL PROGRAM: A BRITISH COHORT STUDY
Authors: Clare Linda , Victor Christina 
Published: December 2023

Abstract
IDEAL (Improving the Experience of Dementia and Enhancing Active Life) is a British-based cohort study that commenced in 2014 and recruited 1545 people with dementia and 1277 carers, following them for 3 waves at yearly intervals. IDEAL-2 continued to follow those who remained in the study for a further 3 waves and incorporated 205 additional participants as part of an enrichment cohort. A key research and policy goal is to understand the factors that promote or inhibit ‘living well’ for people with dementia and their carers, defined as the best achievable state of physical, mental and social health. In this symposium we examine how living well outcomes vary longitudinally and with social (minority ethnic status) factors. Two papers focus on quality of life of people with dementia longitudinally. Our first paper shows that for most study participants quality of life scores remained stable. For those with declining quality of life key associated factors include demographic characteristics, cognition, and psychological health including depression. Our second paper has a clinical dimension and demonstrates that, beyond the point of diagnosis, quality of life does not vary according to dementia subtype. Our third paper focuses on social health using social isolation as our measure. Isolation increased over time and was higher in carers than people with dementia. Our final paper demonstrates that, compared with their white British counterparts, minority ethnic carers report higher stress and role captivity and lower relationship quality while people with dementia have lower quality of life and higher loneliness.
DEMENTIA SUBTYPES AND LIVING WELL IN PEOPLE WITH MILD TO MODERATE DEMENTIA. LONGITUDINAL FINDINGS OVER SIX YEARS
Authors: Clare Linda , Martyr Anthony , Gamble Laura , Matthews Fiona 
Published: December 2023

Abstract
The heterogeneity of symptoms across dementia subtypes has important implications for clinical practice and dementia research. Variations in subtypes and associated symptoms may influence capability to ‘live well’ for people with dementia. In this paper we investigate the potential impact of dementia subtypes on the quality of life of people with dementia. We used longitudinal data from 1749 individuals with mild-to-moderate dementia participating in the IDEAL and IDEAL-2 studies. Assessments took place on entry and were followed up at 12, 24, 48, 72 and 96 months. We examined change in quality of life post diagnosis and associations with dementia subtypes using mixed effects models. Slightly more than half of participants , 52.4%, had a diagnosis of Alzheimer’s disease, 10.2% vascular dementia and 19.8% mixed Alzheimer’s and vascular dementia. Rarer subtypes of dementia, frontotemporal, Parkinson’s type, Lewy bodies accounted for 17.6% of participants . Dementia subtype had the greatest associations with quality of life at the time of diagnosis. Compared to individuals with Alzheimer’s disease, those with Parkinson’s disease dementia (-4.89, 95% CI: -6.60 to -3.417) and dementia with Lewy bodies (-4.90, 95% CI: -6.38 to -3.42) had relatively poorer quality of life at baseline. The difference in quality of life for people with vascular dementia (-1.70, 95% CI: -3.55 to -1. 35) and mixed Alzheimer’s and vascular dementia (-1.70 95% CI:-2.47 to -0.92) was less marked. There was little change in quality of life longitudinally and no difference in quality-of-life trajectories by dementia subtype
BRIDGE GERIATRIC WORKFORCE EDUCATION CURRICULUM BETWEEN 4M COMPETENCIES AND INTERDISCIPLINARY EDUCATION
Authors: Yoo Ji , Shen Jay , choe Ian , Tabrizi maryam , Ioanitoaia-Chaudhry Iulia 
Published: December 2023

Abstract
In a provider shortage area, education priority strategy is more practical rather than structure investment priority strategy. In aims of establishing Age-Friendly Community in this state where primary care provider number per capita ranks 50th state, 4Ms (What Matters, Mobility, Medication, Mentation) based interdisciplinary education across medicine, dental, pharmacy, nursing, social work, physical therapy were developed and implemented. We evaluated the impact of 4Ms application on healthcare providers education by measuring served patient outcomes (1) CMS defined Merit Incentive Payment System, patient satisfaction, and healthcare cost and (2) education outcomes of healthcare providers using 4M education competencies. We adopted STEPPS interprofessional communication skill toolkit and applied simulation training with standardized patients.