bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELAYANAN AKTA KEMATIAN MELALUI INOVASI PETI MEGATRUH PADA DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN KEBUMEN
Authors: Shidiqoh Arsa Wafa , Putri Nadya Anggara 
Published: December 2023

Pelayanan terkait akta kematian merupakan salah satu bentuk dari pelayanan publik. Pencatatan dan pelaporan kematian merupakan sesuatu yang penting dan harus dilaporkan, karena pencatatan peristiwa kematian sebagai sumber data statistik yang akurat. Dinas Kependudukan dan Pencatatan Sipil Kabupaten Kebumen membuat suatu inovasi dalam pelayanan akta kematian melalui program Inovasi “Peti Megatruh” (Pengelolaan Pelaporan kematian Melalui Gerakan Administasi Kependudukan Cepat, Profesional, Akurat, dan Handal). Adapun tujuan penelitian ini untuk mengetahui bagaimana pelayanan akta kematian melalui program inovasi “Peti Megatruh” serta faktor penghambatnya pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Kebumen. Penelitian ini menggunakan metode kualitatif dan analisis terhadap teori inovasi pelayanan menurut Teori Rogers. Teknik pengumpulan data dilakukan dengan menggunakan wawancara, dokumentasi dan observasi. Kemudian data yang diperoleh dianalisis melalui pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa pelayanan akta kematian menggunakan inovasi “Peti Megatruh” dalam pelayanan akta kematian di Dinas Kependudukan dan Pencatatan Sipil Kabupaten Kebumen belum dapat menjadikan pelayanan tersebut menjadi lebih optimal. Hal ini dikarenakan program inovasi “Peti Megatruh” baru diterapkan dan dalam pelaksanaannya serta masih terdapat beberapa faktor penghambat diantaranya kurangnya sumber daya manusia serta perangkat desa yang belum sepenuhnya memahami konsep inovasi peti megatruh.
Kata kunci: Pelayanan; Inovasi; Administrasi Kependudukan
Entrenamiento muscular respiratorio en el paciente pediátrico con enfermedad respiratoria crónica
Authors: Pereira Rodríguez Javier Eliecer , Curvelo Celedón Grace Carolina 
Published: December 2023

Introducción: Los niños con enfermedades respiratorias crónicas se caracterizan por presentar síntomas respiratorios permanentes que ocasionan compromiso pulmonar, debilidad de los músculos respiratorios y periféricos, para lo cual reciben un tratamiento integral que incluye el entrenamiento muscular respiratorio. Objetivo: Analizar los efectos del entrenamiento muscular respiratorio en el paciente pediátrico con enfermedad respiratoria crónica por medio de una revisión de la literatura publicada entre 2010 y 2021. Materiales y métodos: Revisión integrativa de la literatura, en la que se analizó literatura sobre efectos fisiológicos del entrenamiento muscular respiratorio, herramientas de evaluación de la fuerza respiratoria, métodos de entrenamiento y parámetros para prescribir las cargas de trabajo. Los estudios se identificaron y seleccionaron mediante las recomendaciones de la Declaración de PRISMA, además, se valoró el nivel de evidencia y el grado de recomendación de los estudios incluidos a través de la Escala Scottish Intercollegiate Guidelines Network (SIGN). Resultados: El entrenamiento muscular respiratorio ha mostrado ser beneficioso sobre la fuerza muscular respiratoria en pacientes pediátricos con asma, bronquiectasias y enfermedad neuromuscular, sin embargo, en paciente con fibrosis quística la literatura analizada no es concluyente para apoyar o rechazar los efectos de esta estrategia terapéutica. Conclusión: El entrenamiento muscular respiratorio debe ser individualizado en pacientes pediátricos con enfermedad respiratoria crónica de tipo intra o extrapulmonar, por lo que se requiere una evaluación integral que incluya la valoración de la fuerza y la resistencia muscular ventilatoria para prescribir el entrenamiento
Factores contextuales en la prematurez y el niño con bajo peso al nacer basados en los datos del censo 2018
Authors: Martínez Santa Jaime , Del Pilar Martínez Andrea , Avendaño Vanegas Janneth Milena , Melo Cuervo Alejandra , Alfonso Mantilla Jose Iván 
Published: December 2023

Introducción La prematurez se considera como el nacimiento antes de antes de la semana 37 de edad gestacional y el 65% de estos neonatos presentan bajo peso al nacer (Verdura,2011). La prematurez es la causa más frecuente de morbilidad perinatal y es responsable del 75% de las muertes neonatales. Es así como el objetivo de ese artículo es realizar una descripción de los factores contextuales relacionados con la prematurez en la población colombiana basados en los datos del censo 2018. Método Estudio descriptivo de corte transversal, que utilizó la base de datos de Estadísticas Vitales (DANE), identificando los recién nacidos prematuros para el periodo 1998-2018. Para la caracterización de los factores contextuales se tiene en cuenta las siguientes variables: tiempo de gestación del nacido vivo, sexo, edad de la madre, multiplicidad del embarazo, el estado civil de la madre, nivel educativo y pertenencia étnica. Resultados La prematurez está asociada al bajo peso al nacer en un alto porcentaje en un 35.32%, las mujeres adolescentes (entre los 10 y los 19 años) presentan parto prematuro en un 23.21%, un factor importante es el bajo control prenatal presente en un 77.38% y el bajo nivel de escolaridad de la madre está presente en un 20.14%. Conclusiones Los factores contextuales asociados a la prematurez fueron la presencia de control prenatal y en menos proporción la edad de la madre, el bajo peso al nacer y el nivel de escolaridad de la madre.
Evaluation of atrial fibrillation using wearable device signals and home blood pressure data in the Michigan Predictive Activity & Clinical Trajectories in Health (MIPACT) Study: A Subgroup Analysis (MIPACT-AFib)
Authors: Pastapur Aishwarya , Pescatore Nicole A. , Shah Nirav , Kheterpal Sachin , Nallamothu Brahmajee K. , Golbus Jessica R. 
Published: December 2023

BackgroundThe rising adoption of wearable technology increases the potential to identify arrhythmias. However, specificity of these notifications is poorly defined and may cause anxiety and unnecessary resource utilization. Herein, we report results of a follow-up screening protocol for incident atrial fibrillation/flutter (AF) within a large observational digital health study.MethodsThe MIPACT Study enrolled 6,765 adult patients who were provided an Apple Watch and blood pressure (BP) monitors. From March to July 2019, participants were asked to contact the study team for any irregular heart rate (HR) notification. They were assessed using structured questionnaires and asked to provide 6 Apple Watch EKGs. Those with arrhythmias or non-diagnostic EKGs were sent 7-day monitors. The EHR was reviewed after 3 years to determine if participants developed arrhythmias.Results86 participants received notifications and met inclusion criteria. Mean age was 50.5 (SD 16.9) years, and 46 (53.3%) were female. Of 76 participants assessed by the study team, 32 (42.1%) reported anxiety surrounding notifications. Of 59 participants who sent at least 1 EKG, 52 (88.1%) were in sinus rhythm, 3 (5.1%) AF, 2 (3.4%) indeterminate, and 2 (3.4%) sinus bradycardia. Cardiac monitor demonstrated AF in 2 of 3 participants with AF on Apple Watch EKGs. 2 contacted their PCPs and were diagnosed with AF. In total, 5 cases of AF were diagnosed with 1 additional case identified during EHR review.ConclusionWearable devices produce alarms that can frequently be anxiety provoking. Research is needed to determine the implications of these alarms and appropriate follow-up.
Comparative cardiovascular benefits of individual SGLT2 inhibitors in type 2 diabetes and heart failure: a systematic review and network meta-analysis of randomized controlled trials
Authors: Kongmalai Tanawan , Hadnorntun Phorntida , Leelahavarong Pattara , Kongmalai Pinkawas , Srinonprasert Varalak , Chirakarnjanakorn Srisakul , Chaikledkaew Usa , McKay Gareth , Attia John , Thakkinstian Ammarin 
Published: December 2023

BackgroundIn patients with type 2 diabetes (T2D) and a history of heart failure (HF), sodium–glucose cotransporter-2 inhibitors (SGLT2is) have demonstrated cardiovascular (CV) benefits. However, the comparative efficacy of individual SGLT2is remains uncertain. This network meta-analysis (NMA) compared the efficacy and safety of five SGLT2is (canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and sotagliflozin) on CV outcomes in these patients.Materials and methodsPubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched up to September 23, 2022, to identify all randomized controlled trials (RCTs) comparing SGLT2is to placebo in T2D patients with HF. The main outcomes included composite CV death/heart failure hospitalization (HFH), HFH, CV death, all-cause mortality, and adverse events. Pairwise and NMA approaches were applied.ResultsOur analysis included 11 RCTs with a total of 20,438 patients with T2D and HF. All SGLT2is significantly reduced HFH compared to standard of care (SoC) alone. “Add-on” SGLT2is, except ertugliflozin, significantly reduced composite CV death/HFH relative to SoC alone. Moreover, canagliflozin had lower composite CV death/HFH compared to dapagliflozin. Based on the surface under the cumulative ranking curve (SUCRA), the top-ranked SGLT2is for reducing HFH were canagliflozin (95.5%), sotagliflozin (66.0%), and empagliflozin (57.2%). Head-to-head comparisons found no significant differences between individual SGLT2is in reducing CV death. “Add-on” SGLT2is reduced all-cause mortality compared with SoC alone, although only dapagliflozin was statistically significant. No SGLT2is were significantly associated with serious adverse events. A sensitivity analysis focusing on HF-specific trials found that dapagliflozin, empagliflozin, and sotagliflozin significantly reduced composite CV death/HFH, consistent with the main analysis. However, no significant differences were identified from their head-to-head comparisons in the NMA. The SUCRA indicated that sotagliflozin had the highest probability of reducing composite CV death/HFH (97.6%), followed by empagliflozin (58.4%) and dapagliflozin (44.0%).ConclusionSGLT2is significantly reduce the composite CV death/HFH outcome. Among them, canagliflozin may be considered the preferred treatment for patients with diabetes and a history of heart failure, but it may also be associated with an increased risk of any adverse events compared to other SGLT2is. However, a sensitivity analysis focusing on HF-specific trials identified sotagliflozin as the most likely agent to reduce CV death/HFH, followed by empagliflozin and dapagliflozin.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022353754.
A community health promotion project: Amazing Race for Heart Health
Authors: Reese Jessica A. , Guy Carla , Jay Halana , Ali Tauqeer , Lee Elisa T. , Zhang Ying 
Published: December 2023

IntroductionAmerican Indians have higher rates of cardiovascular disease (CVD), likely due to disproportionate burden of diabetes and limited access to widespread CVD prevention programs such as Honoring the Gift of Heart Health (HGHH), a 10-week CVD risk factor awareness curriculum. Due to its length, HGHH may be difficult to complete; therefore, we aimed to evaluate a shortened CVD risk factor awareness program based on the HGHH educational materials for American Indians residing in southwest Oklahoma, entitled “The Amazing Race for Heart Health.”MethodsWe conducted an interventional study where each participant served as their own control (n = 61), with pre- and post-intervention measurements. We included American Indians from seven tribal nations in southwest Oklahoma. At two interventional meetings we used educational materials and activities from HGHH focusing on nutrition, cholesterol, diabetes, hypertension, physical activity, and heart attack warning signs. McNemar's test was used to determine the effectiveness of the intervention on raising CVD risk factor awareness.ResultsWhen comparing the pre- and post-survey responses, the percentage of correct responses either stayed the same or increased. Knowledge improved in 11/25 (44%, p &lt; 0.05) domains including the difference between good and bad cholesterol and types of physical activity that can prevent CVD. When considering diabetes, knowledge increased regarding the interaction between diabetes and cholesterol in the association with CVD.DiscussionThese results demonstrate that the “Amazing Race for Heart Health,” a shortened CVD risk factor educational program based on the HGHH educational materials, was effective at increasing awareness regarding CVD risk factors.
Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations
Authors: Akhtar Marjahan , Islam Md. Rashedul , Khaton Fatema , Soltana Umma Hany , Jafrin Syeda Anoushka , Rahman Sadia Isfat Ara , Tauheed Imam , Ahmed Tasnuva , Khan Ishtiakul Islam , Akter Afroza , Khan Zahid Hasan , Islam Md. Taufiqul , Khanam Farhana , Biswas Prasanta Kumar , Ahmmed Faisal , Ahmed Shakeel , Rashid Md. Mamunur , Hossain Md. Zakir , Alam Ahmed Nawsher , Alamgir A. S. M. , Rahman Mahbubur , Ryan Edward T. , Harris Jason B. , LaRocque Regina C. , Flora Meerjady Sabrina , Chowdhury Fahima , Khan Ashraful Islam , Banu Sayera , Shirin Tahmina , Bhuiyan Taufiqur Rahman , Qadri Firdausi 
Published: December 2023

BackgroundUnderstanding the characteristics of the humoral immune responses following COVID-19 vaccinations is crucial for refining vaccination strategies and predicting immune responses to emerging SARS-CoV-2 variants.MethodsA longitudinal analysis of SARS-CoV-2 spike receptor binding domain (RBD) specific IgG antibody responses, encompassing IgG subclasses IgG1, IgG2, IgG3, and IgG4 was performed. Participants received four mRNA vaccine doses (group 1; n=10) or two ChAdOx1 nCoV-19 and two mRNA booster doses (group 2; n=19) in Bangladesh over two years.ResultsFindings demonstrate robust IgG responses after primary Covishield or mRNA doses; declining to baseline within six months. First mRNA booster restored and surpassed primary IgG responses but waned after six months. Surprisingly, a second mRNA booster did not increase IgG levels further. Comprehensive IgG subclass analysis showed primary Covishield/mRNA vaccination generated predominantly IgG1 responses with limited IgG2/IgG3, Remarkably, IgG4 responses exhibited a distinct pattern. IgG4 remained undetectable initially but increased extensively six months after the second mRNA dose, eventually replacing IgG1 after the 3rd/4th mRNA doses. Conversely, initial Covishield recipients lack IgG4, surged post-second mRNA booster. Notably, mRNA-vaccinated individuals displayed earlier, robust IgG4 levels post first mRNA booster versus Covishield counterparts. IgG1 to IgG4 ratios decreased with increasing doses, most pronounced with four mRNA doses. This study highlights IgG response kinetics, influenced by vaccine type and doses, impacting immunological tolerance and IgG4 induction, shaping future vaccination strategies.ConclusionsThis study highlights the dynamics of IgG responses dependent on vaccine type and number of doses, leading to immunological tolerance and IgG4 induction, and shaping future vaccination strategies.
Effect of binary raw materials replacement (quartz and feldspar) for porcelain chamotte on the electro-technical siliceous porcelain properties
Authors: Rodríguez Edén A. , Díaz-Tato Leonel , López-Perales J. F. , González-Carranza Yadira 
Published: December 2023

The hurry for ecological practices and waste control has emerged as an obligation in modern times, demanding precise strategies to restrain waste accumulation and to stimulate recycling and reuse actions to lower the climate effect. The replacement of binary raw materials for porcelain chamotte waste in siliceous porcelain was studied to obtain eco-friendly high-voltage porcelain. Quartz and feldspar were progressively replaced by 5, 10, and 15 wt.% of porcelain chamotte in a conventional siliceous electro-technical porcelain composition. The replacement effect on sintered samples at 1250°C under industrial heat treatment was evaluated by measuring the linear shrinkage, bulk density, porosity, flexural strength, and microhardness technological properties. Phase analysis was carried out by X-ray diffraction. Microstructural characteristics were studied using a scanning electron microscope. The results showed that chamotte-containing samples reached bulk densities of about 2.36 g/cm3 and a porosity percentage near zero. The maximum flexural strength value at glazed states was 87.8 MPa, for 15 wt.% scrap-containing samples. X-ray diffraction studies revealed a higher mullite phase content in chamotte-containing samples. Scanning electronic microscopy images of the polished and etched specimens show the presence of quartz grains and secondary mullite needles embedded in a feldspathic vitreous matrix. The properties reached by the chamotte-containing samples are attractive since the values obtained in terms of flexural strength, density, and porosity are compared to those reported for conventional siliceous porcelain were obtained. The most noticeable result was observed in flexural resistance. The glazed porcelain bodies showed a flexural strength improvement of about 15%. Then, these porcelain compositions suggest an alternative to produce a more sustainable, affordable, and environmentally-friendly porcelain insulator product.
Possible risk factors of opaque bubble layer and its effect on high-order aberrations after small incision Lenticule extraction
Authors: Yang Shan , Wang Heng , Chen Zhengyu , Li Ying , Chen Youxin , Long Qin 
Published: December 2023

PurposeTo evaluate the possible risk factors of opaque bubble layer (OBL) formation in small incision lenticule extraction (SMILE) surgery and its effects on visual quality.MethodsFifty-six eyes from 28 patients were included in this study. The preoperative parameters and intraoperative designs were recorded. Corneal high-order aberrations (HOAs), point spread function (PSF), and modulation transfer function (MTF) were measured using iTrace at pre-operation, 1 week, 1 month, and 3 months after SMILE. Generalized Estimating Equation and Linear Mixed Effects Model were employed for statistical analysis.ResultsThe mean OBL area in SMILE surgery was 2.75% ± 1.25%. The patients were divided into groups based on whether the OBL was greater than the mean group or less than the mean group. Compared to the group with a smaller OBL area, the group with the larger OBL area had steeper corneal curvature and thinner cap thickness, the OBL area was positively correlated with the preoperative keratometry (r = 0.21, p = 0.04) and preoperative spherical value (r = 0.47, p = 0.01). The group with the larger OBL area induced more corneal SA and trefoil at 1 week postoperatively, but the difference was not significant at 1 month and 3 months postoperatively.ConclusionA steep corneal curvature, thin cap thickness, and high preoperative spherical value are possible risk factors for OBL formation in SMILE surgery. The OBL increased the ocular and corneal HOAs postoperatively for a short period (1 week), while it did not affect the long-term outcomes.
Impact of lockdown on children with type-1 diabetes: returning to the community was associated with a decrease in HbA1c
Authors: Morat Benjamin , Lucidarme Nadine , Gibert Auriane , Harbulot Carole , Lachaume Noémie , Gréteau Stéphanie , Basmaci Romain 
Published: December 2023

BackgroundIn March 2020, a 2-month lockdown of the entire population has been declared in France to limit the spread of COVID-19. Sudden changes in daily life can impact the glycemic control of patients with type 1 diabetes (T1D), especially children and adolescents. We aimed to assess the impact of the lockdown on glycemic control in children and adolescents with T1D.MethodsChildren with T1D were prospectively recruited in two pediatric centers from May 11 to August 1, 2020. At inclusion, patients and/or parents were asked to fill in a form assessing the patient's lifestyle during the lockdown and a medical case report form was filled in by clinician. The mean of the three last glycated hemoglobin (HbA1c) values obtained before lockdown (HbA1c_mean; before March 17, 2020) was compared to the first HbA1c value measured after the lockdown (HbA1c_after; from May 11 to August 1, 2020). Univariable and multivariable analyses were performed, as appropriate, to identify factors associated with glycemic changes during lockdown.ResultsOne-hundred-and-eighteen children and adolescents (median age was 14.1 years, 50% males) with T1D (median time from diagnosis was 4.1 years) were enrolled in the study. No significant difference was observed between medians of HbA1c_mean and HbA1c_after values (8.37% [7.88; 9.32%] vs. 8.50% [7.70; 9.50%], respectively; p = 0.391). Returning to the community was a protective factor [OR 0.31 (0.09–0.94); p = 0.045]. Patients having increased HbA1c were more frequently in contact with a suspected case of COVID-19 [OR 9.07 (2.15–53.66); p = 0.006], whereas patients having decreased HbA1c had the feeling of increase number of hypoglycemia [OR 0.19 (0.05–0.57); p = 0.006].ConclusionIn our patients, HbA1c before and after the lockdown was stable. In subgroup analysis, returning to the community was a protective factor. In addition, feeling of hypoglycemia was more frequent in the patients with decreased HbA1c.
The role of ARL4C in predicting prognosis and immunotherapy drug susceptibility in pan-cancer analysis
Authors: Zhao Hanshu , Yang Kaiqi , Yue Ziqi , Chen Ziyin , Cheng Zhe , Sun Hongcheng , Song Changze 
Published: December 2023

Background: ARLs, which are a class of small GTP-binding proteins, play a crucial role in facilitating tumor tumorigenesis and development. ARL4C, a vital member of the ARLs family, has been implicated in the progression of tumors, metastatic dissemination, and development of resistance to therapeutic drugs. Nevertheless, the precise functional mechanisms of ARL4C concerning tumor prognosis and immunotherapy drug susceptibility remain elusive.Methods: By combining the GTEx and TCGA databases, the presence of ARL4C was examined in 33 various types of cancer. Immunohistochemistry and immunofluorescence staining techniques were utilized to confirm the expression of ARL4C in particular tumor tissues. Furthermore, the ESTIMATE algorithm and TIMER2.0 database were utilized to analyze the tumor microenvironment and immune infiltration associated with ARL4C. The TISCH platform facilitated the utilization of single-cell RNA-seq datasets for further analysis. ARL4C-related immune escape was investigated using the TISMO tool. Lastly, drug sensitivity analysis was conducted to assess the sensitivity of different types of tumors to compounds based on the varying levels of ARL4C expression.Results: The study found that ARL4C was highly expressed in 23 different types of cancer. Moreover, the presence of high ARL4C expression was found to be associated with a poor prognosis in BLCA, COAD, KIRP, LGG, and UCEC. Notably, ARL4C was also expressed in immune cells, and its high expression was found to be correlated with cancer immune activation. Most importantly, the drug sensitivity analysis revealed a positive correlation between ARL4C expression and the heightened sensitivity of tumors to Staurosporine, Midostaurin, and Nelarabine.Conclusion: The findings from our study indicate that the expression level of ARL4C may exert an influence on cancer development, prognosis, and susceptibility to immunotherapy drugs. In addition, the involvement of ARL4C in the tumor immune microenvironment has expanded the concept of ARL4C-targeted immunotherapy.