bluuebunny/crossref_metadata_2025_split huggingface dataset:
The poor reliability of thermal conductivity data in the aerogel literature: a call to action!
Authors: Malfait Wim J. , Ebert Hans-Peter , Brunner Samuel , Wernery Jannis , Galmarini Sandra , Zhao Shanyu , Reichenauer Gudrun 
Published: January 2024

AbstractAerogels are an exciting class of materials with record-breaking properties including, in some cases, ultra-low thermal conductivities. The last decade has seen a veritable explosion in aerogel research and industry R&D, leading to the synthesis of aerogels from a variety of materials for a rapidly expanding range of applications. However, both from the research side, and certainly from a market perspective, thermal insulation remains the dominant application. Unfortunately, continued progress in this area suffers from the proliferation of incorrect thermal conductivity data, with values that often are far outside of what is possible within the physical limitations. This loss of credibility in reported thermal conductivity data poses difficulties in comparing the thermal performance of different types of aerogels and other thermal superinsulators, may set back further scientific progress, and hinder technology transfer to industry and society. Here, we have compiled 519 thermal conductivity results from 87 research papers, encompassing silica, other inorganic, biopolymer and synthetic polymer aerogels, to highlight the extent of the problem. Thermal conductivity data outside of what is physically possible are common, even in high profile journals and from the world’s best universities and institutes. Both steady-state and transient methods can provide accurate thermal conductivity data with proper instrumentation, suitable sample materials and experienced users, but nearly all implausible data derive from transient methods, and hot disk measurements in particular, indicating that under unfavorable circumstances, and in the context of aerogel research, transient methods are more prone to return unreliable data. Guidelines on how to acquire reliable thermal conductivity data are provided. This paper is a call to authors, reviewers, editors and readers to exercise caution and skepticism when they report, publish or interpret thermal conductivity data.
Graphical Abstract
The Relationship of Life-Changing Spiritual Experiences to Current Religious/Spiritual Attitudes and Practices: A Pilot Study
Authors: Cseh Orsolya , Karsai István , Szabo Attila 
Published: January 2024

AbstractPositive life changes may be associated with spiritual/religious sources. This pilot study tested religiousness/spirituality in adults (N = 77; 21% men; Mage = 39.45, SD = 11.97 years) who answered demographic questions and completed the Brief Multidimensional Measure of Religiousness/Spirituality. Respondents who reported a major life-changing spiritual experience (72.7%) were compared to those who did not (27.3%). The former scored higher (p < .05) on all measures and had a higher proportion of religious (p = .04) and spiritual (p < .001) identity. At the same time, no differences in age, gender, education, or urban vs. rural location emerged. Among those who had experienced a significant life change, 42.9% had such experiences when they were 18 years or younger. Most (83.4%) were committed spiritually and attended religious services once or more weekly. The age at which the life-changing experience occurred correlated strongly (r = .70) with the strengthening of religious/spiritual practices. The results suggest that life-changing spiritual experiences fuel religious/spiritual attitudes and behaviors and that their impact may be more profound if experienced at a younger age.
The added worker effect: evidence from a disability insurance reform
Authors: Bernasconi Mario , Kantarcı Tunga , van Soest Arthur , van Sonsbeek Jan-Maarten 
Published: January 2024

AbstractThe Netherlands reformed its disability insurance (DI) scheme in 2006. Reintegration incentives for employers became stronger, access to DI benefits became more difficult, and benefits became less generous. Using administrative data on all individuals who fell sick shortly before and after the reform, we study the impact of the reform on labor participation of individuals who fell sick and their spouses. Difference-in-differences estimates show, among other things, that the reform led to an increase of labor participation of the individuals who fell sick only if these individuals had a permanent job, whereas spouses responded to the DI reform in other cases, where the individuals reporting sick had a temporary job or were unemployed. More generally, the spouses respond when the sick individual’s labor market position is weak and the individual him- or herself has trouble finding or retaining employment. The effects are persistent during the 10 years after the reform. The effect on the spouse can be seen as an “added worker effect,” where additional earnings of the spouse compensate for the sick individual’s income loss so that both partners share the burden of a more stringent DI scheme. Comparing individuals reporting sick with and without partner provides further support for the notion that the responses of couples to the reform are joint decisions of the two partners.
HBV Reactivation in Patients Receiving Bruton Tyrosine Kinase Inhibitors (BTKIs): a Systematic Review and Meta-Analysis
Authors: Azzam Ahmed , Khaled Heba , Ashry Basem Osama , Hussein Sarah Mohamed , Osama Manar , Ahmed Ameer , Yousef Omar , Hjazeen Anees , Allam Ahmed A. , Kamel Gellan Alaa Mohamed 
Published: January 2024

Abstract
Purpose of Review
Bruton tyrosine kinase inhibitors (BTKIs) are immunosuppressive cancer therapies approved for the treatment of various mature B-cell malignancies. Hepatitis B virus reactivation (HBVr) is a known complication in patients with chronic or past HBV infection undergoing immunosuppressive chemotherapy. The present work aims to establish the correlation between HBVr and patients receiving BTKIs.

Recent Findings
This review included 18 studies. The overall incidence of HBVr was found to be 6.6% in patients with past HBV infections who received ibrutinib. Fourteen cases of HBVr were associated with ibrutinib (two occult hepatitis B infections and twelve past HBV infections). One case of HBV past infection was associated with zanubrutinib, and three cases were recorded for acalabrutinib (one chronic HBV and two past HBV). Most incidents occurred in males older than 60 years within the first year after initiating BTKIs. Three reported cases documented HBVr after discontinuing ibrutinib and zanubrutinib. Two deaths caused by HBVr in patients with past HBV infections were recorded (one for each of acalabrutinib and ibrutinib). Remarkably, HBV antiviral treatment normalized liver functions and eliminated serum HBV in most cases. It was reported that false negativity of HBsAg following reactivation occurred in two cases: one case was attributed to HBsAg escape mutations, and the other to the hook effect.

Summary
Our findings show that HBVr risk is intermediate in patients with past HBV infections who receive ibrutinib. Universal anti-HBV prophylaxis before initiating ibrutinib may be an option.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation
Authors: Feng Shu , Xie Xingming , Li Jianchao , Xu Xu , Chen Chaochun , Zou Gaoliang , Lin Guoyuan , Huang Tao , Hu Ruihan , Ran Tao , Han Lu , Zhang Qingxiu , Li Yuanqingxiao , Zhao Xueke 
Published: January 2024

Abstract
Background
Altered patterns of bile acids (BAs) are frequently present in liver fibrosis, and BAs function as signaling molecules to initiate inflammatory responses. Therefore, this study was conducted to uncover the notably altered components of BAs and to explore the pathway of altered BA induced inflammation in the development of liver fibrosis.

Methods
Bile acids were quantified by ultraperformance liquid chromatography coupled to mass spectrometry (UPLC‒MS/MS). Cell Counting Kit-8 assays were used to determine the proliferative capacity of HSCs. Transwell assays and wound healing assays were used to determine the migratory capacity of LX2 cells. Protein expression was evaluated by western blotting.

Results
Plasma bile acid analysis showed higher levels of GCDCA, TCDCA, GCA and TCA in patients with liver fibrosis than in normal controls. The AUC of GCDCA was the highest. Western blotting showed that GCDCA treatment increased the expression of NLRP3-related proteins and collagen1 in vitro and significantly increased LX2 cells proliferation and migration. Furthermore, knockdown of NLRP3 or overexpression of FXR in LX2 cells decreased the expression of the above proteins, and FXR inhibited NLRP3 (ser 295) phosphorylation in vitro and vivo. In vivo, HE, Masson’s trichrome, and Sirius Red staining showed that GCDCA increased collagen fibers in the mouse liver, and the expression of NLRP3-related proteins, collagen 1, and α-SMA in the liver increased significantly. However, the knockout of NLRP3 reversed these patterns.

Conclusion
(1) Primary conjugated bile acids increased in patients with liver fibrosis; (2) GCDCA induce hepatic fibrosis via the NLRP3 inflammasome pathway; (3) FXR inhibits NLRP3 activity by restraining its phosphorylation; (4) knockdown or knockout of NLRP3 may relieve the onset of hepatic fibrosis.
Impact of Systemic Therapy on Fertility in Women with Early-Stage Breast Cancer
Authors: Natsuhara Kelsey H. , Chien A. Jo 
Published: January 2024

Abstract
Purpose of Review
Fertility concerns are common among young women diagnosed with breast cancer, as systemic therapy increases the risk of premature ovarian insufficiency and delays family planning. Here, we review the impact of systemic therapies, including chemotherapy, endocrine therapy, HER-2 directed therapy, PARP inhibitors, and immunotherapy, on ovarian reserve.

Recent Findings
With an improved understanding of disease biology, fewer women are treated with gonadotoxic chemotherapy. There are limited data on the fertility impact of novel targeted treatments and immunotherapy, though preclinical and preliminary studies suggest an impact on fertility is possible. Notably, a recent study investigated the outcomes in women who interrupted adjuvant endocrine therapy to attempt pregnancy.

Summary
Further research is needed to characterize the fertility impact of novel therapies in breast cancer. Individualized fertility counseling should be offered to all women to discuss the possible impact of therapy on ovarian reserve and options for fertility preservation and timing of pregnancy.
A new three-dimensional rock strength criterion based on shape function in deviatoric plane
Authors: Gao Xiangsen , Wang Min , Li Cui , Zhang Mingming , Li Zhihong 
Published: January 2024

AbstractRock strength criteria are the theoretical grounding of geotechnical design and stability estimation, the Mohr–Coulomb (MC) and Hoek–Brown (HB) criteria are the widely accepted criteria at present, due to their reasonability and unambiguous concept, however they overlook the effect of intermediate principal stress, and contain six singular corners in π plane. Aimed at overcoming those limitations, the MC and normal parabolic criterion (NPC) were improved to their 3D versions that lead to smooth and convex for a wide range of strength parameters. The extended 3D strength criteria coincide with corresponding original forms in the triaxial compression and triaxial extension states, which not only take intermediate principal stress into account, but also provide great convenient in numerical calculation. Multigroup of poly-axial strength datasets gathered from the references are used to check the prediction accuracy of the proposed 3D criteria by the least absolute deviation method. Research proved that the 3D NPC criterion has a relatively larger deviation on poly-axial strength data prediction, but the proposed 3D MC criterion can describe peak strength with low misfit for soft or hard rocks. Peak strength σ1 increases first and then decreases with the increase of σ2, whether increasing or decreasing σ2, both will result in rock failure. Moreover, the 3D MC can fit the poly-axial strength data well for lower or higher values of σ3, which strongly suggests the proposed 3D MC criterion is adequate. Applicability of the proposed strength criterion will be discussed in further research.
Cost evaluation of a nurse coordinated outpatient parenteral antimicrobial therapy (OPAT) program
Authors: Deng Huiwen , Gross Alan E. , Trotter Andrew B. , Touchette Daniel R. 
Published: January 2024

Abstract
A structured, nurse-driven outpatient parenteral antimicrobial therapy (OPAT) program within an academic healthcare system was associated with reduced odds of 60-day unplanned OPAT readmissions and costs after hospital discharge. These findings may facilitate justifying additional resources for OPAT programs to improve care while decreasing costs.
A nationwide survey of Antimicrobial Stewardship in Pediatric Intensive Care Unit: implementation notes from the Brazilian underground
Authors: Krummenauer Eliane Carlosso , Ziembowicz Henrique , Gonçalves Mara Rubia Santos , Costa Magda Machado de Miranda , Assis Mariana Portela de , Dias Viviane Maria de Carvalho Hessel , Vidal Cláudia Fernanda de Lacerda , Menezes Rochele Mosmann , Renner Jane Dagmar Pollo , Carneiro Marcelo 
Published: January 2024

Abstract
A multicenter diagnostic study was conducted to investigate the implementation of an Antimicrobial Stewardship Program in Brazilian Pediatric Intensive Care Units. The analysis unveiled the main implementation impediments of the Antimicrobial Stewardship Program such as the lack of professionals and resources available to the program.
STRONG MEASURE ZERO SETS ON FOR INACCESSIBLE
Authors: CHAPMAN NICK STEVEN , SCHÜRZ JOHANNES PHILIPP 
Published: January 2024

Abstract
We investigate the notion of strong measure zero sets in the context of the higher Cantor space

$2^\kappa $

for

$\kappa $

at least inaccessible. Using an iteration of perfect tree forcings, we give two proofs of the relative consistency of

$$\begin{align*}|2^\kappa| = \kappa^{++} + \forall X \subseteq 2^\kappa:\ X \textrm{ is strong measure zero if and only if } |X| \leq \kappa^+. \end{align*}$$

Furthermore, we also investigate the stronger notion of stationary strong measure zero and show that the equivalence of the two notions is undecidable in ZFC.
Sedimentological and geochemical traces of metallurgical activity in the Świślina River valley (central Poland) at the Doły Biskupie site
Authors: Przepióra Paweł , Kalicki Tomasz 
Published: January 2024

AbstractPrehistoric and historic iron metallurgy in the Holy Cross Mountains in central Poland developed along with human Przeworsk Culture activity (during the Roman period) and within the boundaries of the Old-Polish Industrial District (OPID) during the Middle Ages and during recent centuries. At the Świślina catchment, there are many archaeological sites showing intense prehistoric metallurgical activity. The later medieval and modern iron industry was significantly smaller. At the Doły Biskupie site, slags and microscopic iron spherules (hammerscales) were found in alluvia. The microscopic spherules separation method (MSS) enabled analysis of these small artefacts created during iron ore smelting and forging. Iron spherules were detected in floodplain sediments, which are characterized by increased content of trace elements. The presence of these artefacts in shallow sediment layers in the confluence section of the river may be an indicator of archaeologically confirmed prehistoric metallurgical activity in the catchment area. Study of these residues enabled an attempt to reconstruct the river valley environment during the prehistoric and historical period. The MSS method can be used to detect iron spherules in alluvia in other river catchments, confirming the presence of yet-undiscovered bloomery sites.
Long-term warming altered soil physical structure and soil organic carbon pools in wheatland field
Authors: Ma Rentian , Kou Taiji , Cheng Xianghan , Yu Ning 
Published: January 2024

Summary
The impacts of long-term warming on soil physical structure and soil organic carbon (SOC) pools are currently disputed and uncertain. We conducted an eleven-year warming experiment in wheatland field in Henan, China. We found that long-term warming significantly increased soil bulk density by 4.5%, and significantly decreased total porosity and non-capillary porosity by 3.4% and 5.0%, respectively. Besides, long-term warming decreased the >2 mm fraction proportion and increased <0.053 mm fraction proportion of dry and wet aggregates. The mean weight diameter value for dry and wet aggregates in long-term warming treatment was significantly decreased by 7.0% and 6.7%, respectively. Moreover, long-term warming significantly decreased the total SOC, very labile pool (F1) and labile pool (F2) content by 10.6%, 30.6%, and 43.6%, and significantly increased the less labile pool (F3) and non-labile pool (F4) content by 94.2% and 21.1%, respectively. Long-term warming increased the passive carbon pool percentage but decreased the active carbon pool (ACP) percentage. Our results suggest that long-term warming negatively affected the soil's physical structure and impaired soil ACP accumulation. The findings of this study help improve our understanding of the response of farmland soils in northern China to climate change and provide scientific basis for establishing carbon management measures in farmland.
Recent trends in populations of Critically Endangered Gyps vultures in India
Authors: Prakash Vibhu , Bajpai Hemant , Chakraborty Soumya S. , Singh Mahadev Manan , Mallord John W. , Prakash Nikita , Ranade Sachin P. , Shringarpure Rohan N. , Bowden Christopher G. R. , Green Rhys E. 
Published: January 2024

Summary
This paper reports results from the eighth of a series of road transect surveys of Gyps vultures conducted across northern, central, western, and north-eastern India since the early 1990s. Populations of the White-rumped Vulture Gyps bengalensis, Indian Vulture G. indicus, and Slender-billed Vulture G. tenuirostris declined rapidly, beginning in the mid-1990s. The principal cause of the declines was poisoning due to widespread veterinary use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac on cattle. The results of the current survey suggest that, while populations of all three species of vulture remain at a low level with no signs of recovery, they appear to have been approximately stable since veterinary use of diclofenac was banned in the mid-2000s. Population trends in India, where the illegal use of diclofenac and legal use of other toxic NSAIDs continues, are compared with more positive trends in Nepal, where the veterinary use of toxic NSAIDs appears to have been reduced to a low level.
Urban school neighbourhoods dominated by unhealthy food retailers and advertisements in Greater Tunis: a geospatial study in the midst of the nutrition transition
Authors: Akl Christelle , El-Helou Nehmat , Safadi Gloria , Semaan Aline , El Sammak Aya , Trabelsi Tarek , Sassi Sonia , Akik Chaza , El Ati Jalila , Traissac Pierre , Ghattas Hala ,   The SCALE Research Group
Published: January 2024

Abstract

Objective:
Food environments are a major determinant of children’s nutritional status. Scarce evidence on food environments exists in low- and middle-income countries (LMIC). This study aims to fill this gap by documenting the obesogenicity of food environments around schools in Greater Tunis, Tunisia – an LMIC of the Middle East and North Africa region with an ongoing nutrition transition and increasing rates of childhood obesity.

Design:
In this cross-sectional study, we assessed built food environments around fifty primary schools. Ground-truthing was performed to collect geographic coordinates and pictures of food retailers and food advertisement sets within an 800-m road network buffer of each school. Retailers and advertisement sets were categorised as healthy or unhealthy according to a NOVA-based classification. Associations between school characteristics and retailers or advertisement sets were explored using multinomial regression models.

Setting:
Greater Tunis, Tunisia.

Participants:
Random sample of fifty (thirty-five public and fifteen private) primary schools.

Results:
Overall, 3621 food retailers and 2098 advertisement sets were mapped. About two-thirds of retailers and advertisement sets were labelled as unhealthy. Most retailers were traditional corner stores (22 %) and only 6 % were fruit and vegetable markets. The prevailing food group promoted was carbonated and sugar-sweetened beverages (22 %). The proportion of unhealthy retailers was significantly higher in the richest v. poorest areas.

Conclusions:
School neighbourhood food environments included predominantly unhealthy retailers and advertisements. Mapping of LMIC food environments is crucial to document the impact of the nutrition transition on children’s nutritional status. This will inform policies and interventions to curb the emergent childhood obesity epidemic.
Association Between Air Pollution and Cardiovascular Disease Hospitalizations in Lanzhou City, 2013–2020: A Time Series Analysis
Authors: Yu Jingze , Zhu Anning , Liu Miaoxin , Dong Jiyuan , Chen Rentong , Tian Tian , Liu Tong , Ma Li , Ruan Ye 
Published: January 2024

AbstractExtensive evidence has shown that air pollution increases the risk of cardiovascular disease (CVD) admissions. We aimed to explore the short‐term effect of air pollution on CVD admissions in Lanzhou residents and their lag effects. Meteorological data, air pollution data, and a total of 309,561 daily hospitalizations for CVD among urban residents in Lanzhou were collected from 2013 to 2020. Distributed lag non‐linear model was used to analyze the relationship between air pollutants and CVD admissions, stratified by gender, age, and season. PM2.5, NO2, and CO have the strongest harmful effects at lag03, while SO2 at lag3. The relative risks of CVD admissions were 1.0013(95% CI: 1.0003, 1.0023), 1.0032(95% CI: 1.0008, 1.0056), and 1.0040(95% CI: 1.0024, 1.0057) when PM2.5, SO2, and NO2 concentrations were increased by 10 μg/m³, respectively. Each 1 mg/m3 increase in CO concentration was associated with a relative risk of cardiovascular hospitalization of risk was 1.0909(95% CI: 1.0367, 1.1479). We observed a relative risk of 0.9981(95% CI: 0.9972, 0.9991) for each 10 μg/m³ increase in O3 for CVD admissions at lag06. We found a significant lag effects of air pollutants on CVD admissions. NO2 and CO pose a greater risk of hospitalization for women, while PM2.5 and SO2 have a greater impact on men. PM2.5, NO2, and CO have a greater impact on CVD admissions in individuals aged <65 years, whereas SO2 affects those aged ≥65 years. Our research indicates a possible short‐term impact of air pollution on CVD. Local public health and environmental policies should take these preliminary findings into account.
Cell competition and cancer from Drosophila to mammals
Authors: Cong Bojie , Cagan Ross L. 
Published: January 2024

AbstractThroughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of ‘cell competition’, can shift clone dynamics by evaluating the relative status of clonal populations, promoting ‘winners’ and eliminating ‘losers’. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.