bluuebunny/crossref_metadata_2025_split huggingface dataset:
STIM1 in tumor cell death: angel or devil?
Authors: Ren Ran , Li Yongsheng 
Published: November 2023

AbstractStromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca2+ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca2+), which is closely associated with tumor cell proliferation, metastasis, apoptosis, autophagy, metabolism and immune processes. STIM1 is not only regulated at the transcriptional level by NF-κB and HIF-1, but also post-transcriptionally modified by miRNAs and degraded by ubiquitination. Recent studies have shown that STIM1 or Ca2+ signaling can regulate apoptosis, autophagy, pyroptosis, and ferroptosis in tumor cells and act discrepantly in different cancers. Furthermore, STIM1 contributes to resistance against antitumor therapy by influencing tumor cell death. Further investigation into the mechanisms through which STIM1 controls other forms of tumor cell death could aid in the discovery of novel therapeutic targets. Moreover, STIM1 has the ability to regulate immune cells within the tumor microenvironment. Here, we review the basic structure, function and regulation of STIM1, summarize the signaling pathways through which STIM1 regulates tumor cell death, and propose the prospects of antitumor therapy by targeting STIM1.
Biallelic ATP2B1 variants as a likely cause of a novel neurodevelopmental malformation syndrome with primary hypoparathyroidism
Authors: Yap Patrick , Riley Lisa G. , Kakadia Purvi M. , Bohlander Stefan K. , Curran Ben , Rahimi Meer Jacob , Alburaiky Salam , Hayes Ian , Oppermann Henry , Print Cristin , Cooper Sandra T. , Le Quesne Stabej Polona 
Published: November 2023

AbstractATP2B1 encodes plasma membrane calcium-transporting-ATPase1 and plays an essential role in maintaining intracellular calcium homeostasis that regulates diverse signaling pathways. Heterozygous de novo missense and truncating ATP2B1 variants are associated with a neurodevelopmental phenotype of variable expressivity. We describe a proband with distinctive craniofacial gestalt, Pierre-Robin sequence, neurodevelopmental and growth deficit, periventricular heterotopia, brachymesophalangy, cutaneous syndactyly, and persistent hypocalcemia from primary hypoparathyroidism. Proband-parent trio exome sequencing identified compound heterozygous ATP2B1 variants: a maternally inherited splice-site (c.3060+2 T > G) and paternally inherited missense c.2938 G > T; p.(Val980Leu). Reverse-transcription-PCR on the proband’s fibroblast-derived mRNA showed aberrantly spliced ATP2B1 transcripts targeted for nonsense-mediated decay. All correctly-spliced ATP2B1 mRNA encoding p.(Val980Leu) functionally causes decreased cellular Ca2+ extrusion. Immunoblotting showed reduced fibroblast ATP2B1. We conclude that biallelic ATP2B1 variants are the likely cause of the proband’s phenotype, strengthening the association of ATP2B1 as a neurodevelopmental gene and expanding the phenotypic characterization of a biallelic loss-of-function genotype.
Temperate species underfill their tropical thermal potentials on land
Authors: Moore Nikki A. , Morales-Castilla Ignacio , Hargreaves Anna L. , Olalla-Tárraga Miguel Ángel , Villalobos Fabricio , Calosi Piero , Clusella-Trullas Susana , Rubalcaba Juan G. , Algar Adam C. , Martínez Brezo , Rodríguez Laura , Gravel Sarah , Bennett Joanne M. , Vega Greta C. , Rahbek Carsten , Araújo Miguel B. , Bernhardt Joey R. , Sunday Jennifer M. 
Published: November 2023

AbstractUnderstanding how temperature determines the distribution of life is necessary to assess species’ sensitivities to contemporary climate change. Here, we test the importance of temperature in limiting the geographic ranges of ectotherms by comparing the temperatures and areas that species occupy to the temperatures and areas species could potentially occupy on the basis of their physiological thermal tolerances. We find that marine species across all latitudes and terrestrial species from the tropics occupy temperatures that closely match their thermal tolerances. However, terrestrial species from temperate and polar latitudes are absent from warm, thermally tolerable areas that they could potentially occupy beyond their equatorward range limits, indicating that extreme temperature is often not the factor limiting their distributions at lower latitudes. This matches predictions from the hypothesis that adaptation to cold environments that facilitates survival in temperate and polar regions is associated with a performance trade-off that reduces species’ abilities to contend in the tropics, possibly due to biotic exclusion. Our findings predict more direct responses to climate warming of marine ranges and cool range edges of terrestrial species.
Interictal invasive very high-frequency oscillations in resting awake state and sleep
Authors: Revajová Karin , Trávníček Vojtěch , Jurák Pavel , Vašíčková Zuzana , Halámek Josef , Klimeš Petr , Cimbálník Jan , Brázdil Milan , Pail Martin 
Published: November 2023

AbstractInterictal very high-frequency oscillations (VHFOs, 500–2000 Hz) in a resting awake state seem to be, according to a precedent study of our team, a more specific predictor of a good outcome of the epilepsy surgery compared to traditional interictal high-frequency oscillations (HFOs, 80–500 Hz). In this study, we retested this hypothesis on a larger cohort of patients. In addition, we also collected patients' sleep data and hypothesized that the occurrence of VHFOs in sleep will be greater than in resting state. We recorded interictal invasive electroencephalographic (iEEG) oscillations in 104 patients with drug-resistant epilepsy in a resting state and in 35 patients during sleep. 21 patients in the rest study and 11 patients in the sleep study met the inclusion criteria (interictal HFOs and VHFOs present in iEEG recordings, a surgical intervention and a postoperative follow-up of at least 1 year) for further evaluation of iEEG data. In the rest study, patients with good postoperative outcomes had significantly higher ratio of resected contacts with VHFOs compared to HFOs. In sleep, VHFOs were more abundant than in rest and the percentage of resected contacts in patients with good and poor outcomes did not considerably differ in any type of oscillations. In conclusion, (1) our results confirm, in a larger patient cohort, our previous work about VHFOs being a specific predictor of the area which needs to be resected; and (2) that more frequent sleep VHFOs do not further improve the results.
Prognostic and immunotherapeutic significance of immunogenic cell death-related genes in colon adenocarcinoma patients
Authors: Xu Jun , Yang Jun , Pan Xianzhu , Wang Jian 
Published: November 2023

AbstractIn recent years, genes associated with immunogenic cell death (ICD)-related genes have garnered significant interest as potential targets for immunotherapy. As a frontier in cancer treatment, immunotherapy has notably enhanced the therapeutic outcomes for cancer patients. However, since only a subset of patients benefits from this treatment approach, there is an imperative need for biomarker research to enhance patient sensitivity to immunotherapy. Expression of ICD-related genes and clinical patient data were sourced from The Cancer Genome Atlas (TCGA) database. Utilizing univariate Cox regression analysis, we constructed a signature for predicting the overall survival of colon adenocarcinoma (COAD) patients. A genomic feature analysis was performed, incorporating tumor mutation burden (TMB) and copy number variation (CNV). The immunological characteristics were analyzed via the ssGSEA and GSEA algorithms, with the resulting data visualized using R software (version 4.2.1). According to the univariate regression analysis for COAD, AIM2 emerged as the gene most significantly associated with overall survival among the 32 ICD-related genes in the TCGA dataset. Patients were divided into two groups based on high or low AIM2 expression, and genomic differences between the groups were explored. Patients expressing high levels of AIM2 had a higher TMB and a lower CNV. In addition, these patients had elevated immune checkpoint, immune cell, and immune function scores, thus indicating increased sensitivity to immunotherapy. TIDE analysis further confirmed that these patients were likely to respond more effectively to immunotherapy. Subclass mapping analysis corroborated our findings, demonstrating that patients with high AIM2 expression responded more positively to immunotherapy. Additionally, our study found that the suppression of AIM2 could significantly enhance the proliferation, invasion, and migration capabilities of colon cancer cells. In this research, we identified a novel prognostic signature suggesting that patients with higher AIM2 expression levels are more likely to respond favorably to immunotherapy.
Deciphering salivary microbiome signature in Crohn’s disease patients with different factors contributing to dysbiosis
Authors: Elzayat Hala , Malik Talha , Al-Awadhi Haifa , Taha Mazen , Elghazali Gehad , Al-Marzooq Farah 
Published: November 2023

AbstractCrohn's disease (CD) is a chronic inflammatory bowel disease. An imbalanced microbiome (dysbiosis) can predispose to many diseases including CD. The role of oral dysbiosis in CD is poorly understood. We aimed to explore microbiome signature and dysbiosis of the salivary microbiome in CD patients, and correlate microbiota changes to the level of inflammation. Saliva samples were collected from healthy controls (HC) and CD patients (n = 40 per group). Salivary microbiome was analyzed by sequencing the entire 16S rRNA gene. Inflammatory biomarkers (C-reactive protein and calprotectin) were measured and correlated with microbiome diversity. Five dominant species were significantly enriched in CD, namely Veillonella dispar, Megasphaera stantonii, Prevotella jejuni, Dolosigranulum pigrum and Lactobacillus backii. Oral health had a significant impact on the microbiome since various significant features were cariogenic as Streptococcus mutans or periopathogenic such as Fusobacterium periodonticum. Furthermore, disease activity, duration and frequency of relapses impacted the oral microbiota. Treatment with monoclonal antibodies led to the emergence of a unique species called Simonsiella muelleri. Combining immunomodulatory agents with monoclonal antibodies significantly increased multiple pathogenic species such as Salmonella enterica, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Loss of diversity in CD was shown by multiple diversity indices. There was a significant negative correlation between gut inflammatory biomarkers (particularly calprotectin) and α-diversity, suggesting more inflammation associated with diversity loss in CD. Salivary dysbiosis was evident in CD patients, with unique microbiota signatures and perturbed species that can serve as disease biomarkers or potential targets for microbiota modulation. The interplay of various factors collectively contributed to dysbiosis, although each factor probably had a unique effect on the microbiome. The emergence of pathogenic bacteria in the oral cavity of CD patients is alarming since they can disturb gut homeostasis and induce inflammation by swallowing, or hematogenous spread of microbiota, their metabolites, or generated inflammatory mediators.
Food without agriculture
Authors: Davis Steven J. , Alexander Kathleen , Moreno-Cruz Juan , Hong Chaopeng , Shaner Matthew , Caldeira Ken , McKay Ian 
Published: November 2023

AbstractEfforts to make food systems more sustainable have emphasized reducing adverse environmental impacts of agriculture. In contrast, chemical and biological processes that could produce food without agriculture have received comparatively little attention or resources. Although there is a possibility that someday a wide array of attractive foods could be produced chemosynthetically, here we show that dietary fats could be synthesized with <0.8 g CO2-eq kcal−1, which is much less than the >1.5 g CO2-eq kcal−1 now emitted to produce palm oil in Brazil or Indonesia. Although scaling up such synthesis could disrupt agricultural economies and depend on consumer acceptance, the enormous potential reductions in greenhouse gas emissions as well as in land and water use represent a realistic possibility for mitigating the environmental footprint of agriculture over the coming decade.
Skilful predictions of the Summer North Atlantic Oscillation
Authors: Dunstone Nick , Smith Doug M. , Hardiman Steven C. , Hermanson Leon , Ineson Sarah , Kay Gillian , Li Chaofan , Lockwood Julia F. , Scaife Adam A. , Thornton Hazel , Ting Mingfang , Wang Lei 
Published: November 2023

AbstractThe Summer North Atlantic Oscillation is the primary mode of atmospheric variability in the North Atlantic region and has a significant influence on regional European, North American and Asian summer climate. However, current dynamical seasonal prediction systems show no significant Summer North Atlantic Oscillation prediction skill, leaving society ill-prepared for extreme summers. Here we show an unexpected role for the stratosphere in driving the Summer North Atlantic Oscillation in both observations and climate prediction systems. The anomalous strength of the lower stratosphere polar vortex in late spring is found to propagate downwards and influence the Summer North Atlantic Oscillation. Windows of opportunity are identified for useful levels of Summer North Atlantic Oscillation prediction skill, both in the 50% of years when the late spring polar vortex is anomalously strong/weak and possibly earlier if a sudden stratospheric warming event occurs in late winter. However, we show that model dynamical signals are spuriously weak, requiring large ensembles to obtain robust signals and we identify a summer ‘signal-to-noise paradox’ as found in winter atmospheric circulation Our results open possibilities for a range of new summer climate services, including for agriculture, water management and health sectors.
Testing MURaM and MPS-ATLAS against the quiet solar spectrum
Authors: Witzke Veronika , Shapiro Alexander I. , Kostogryz Nadiia M. , Mauviard Lucien , Bhatia Tanayveer S. , Cameron Robert , Gizon Laurent , Przybylski Damien , Solanki Sami K. , Unruh Yvonne C. , Yue Li 
Published: November 2023

Context. Three-dimensional (3D) radiative magnetohydrodynamic (MHD) simulations are the only way to model stellar atmospheres without any ad hoc parameterisations. Several 3D radiative MHD codes have achieved good quantitative agreement with observables for our Sun.
Aims. We aim to validate the most recent version of the MURaM code by comparing MURaM results to well-established quiet-Sun measurements, in particular spatially averaged measurements that are relevant for stellar studies. This extends the number of solar observables that MURaM can reproduce with high precision. Our validation is an essential condition to ensure that MURaM can be used to accurately calculate the spectra of other cool stars.
Methods. We simulated the solar photosphere and upper convection zone, which harbours a small-scale-dynamo. Using time series of 3D snapshots, we calculated the spectral irradiance, limb darkening, and selected spectral lines, which we compared to observations.
Results. The computed observables agree well with the observations; in particular, the limb darkening of the quiet Sun is reproduced remarkably well.
Design, research, and production of gear wheels for mining machines
Authors: Ustynenko Oleksandr , Bondarenko Oleksiy , Klymenko Sergij , Riabchenko Sergij , Protasov Roman 
Published: November 2023

The current state of the Ukrainian fuel and energy complex requires a continuous increase in coal production. As part of concept implementation for the coal industry development now created and introduced into serial production a new generation of mining machines. The most loaded element of mining machine is its gear wheels of cutting part. Calculations for the strength and durability of gearings have been carried out. The modelling of the teeth stress-strain state by the finite element method has also been carried out.
Works were carried out on the processing of parts of gearboxes of mining machines.
Investigations of the processes of blade processing of gears and shafts of gearboxes of coal combines were carried out. The state of the surface layer, the quality and accuracy of processing these parts with a blade tool made of superhard materials are determined. Researches of grinding of an involute profile of gear wheels of gearboxes of mining machines are carried out. A study was made of the surface quality and accuracy of gears after grinding with special abrasive wheels.
The influence of processing processes with a tool made of superhard materials on the strength and durability of gear drives of mining machines is determined.
Neue Leitlinien der European Society of Hypertension
Authors: van der Giet Markus 
Published: November 2023

ZUSAMMENFASSUNGEine gute Blutdruckeinstellung ist bei der chronischen Nierenfunktionsstörung (CKD: Chronic Kidney Disease) unerlässlich, um vor allem die Progression der Nierenfunktionsverschlechterung zu reduzieren und auch die sehr hohe kardiovaskuläre Mortalität und Morbidität positiv zu beeinflussen. In zahlreichen Studien konnte gezeigt werden, dass eine systolische Blutdruckeinstellung < 140 mmHg unerlässlich ist, um Patienten mit CKD zu helfen. Deshalb wird in den aktuellen Empfehlungen der European Society of Hypertension (ESH) für Patienten mit CKD empfohlen, den Blutdruck auf jeden Fall < 140 mmHg systolisch abzusenken. Bei jüngeren Patienten (< 65. Lebensjahr), bei Patienten mit hohem kardiovaskulärem Risiko oder bei Patienten mit begleitender Albuminurie sollte der systolische Blutdruck < 130 mmHg gesenkt werden, sofern der Patient dies toleriert. Basis aller Therapie sind Allgemeinmaßnahmen, insbesondere die Kontrolle des Salzkonsums. Zur medikamentösen Blutdruckeinstellung sollte das Renin-Angiotensin-System (RAS) mit einem ACE-Hemmer oder Sartan blockiert werden, wobei eine frühe duale Kombinationstherapie mit einem Kalzium-Kanal-Hemmer oder einem Diuretikum angestrebt werden sollte. Nach einer Eskalation auf maximal tolerable Medikationsdosierungen ist eine Triple-Therapie aus einer RAS-Blockade plus Kalzium-Kanal-Blocker plus Diuretikum notwendig. Ist der Blutdruck immer noch nicht kontrolliert, dann kommen bei der wahren Therapieresistenz β-Blocker, α1-Blocker, zentral wirksame Medikamente oder auch Spironolacton zum Einsatz, wobei bei einer Nierenfunktion < 45 ml/min/1,73 m2 ein hohes Risiko für eine Hyperkaliämie entsteht.
Development of an automatic reading recognition system for liquid-in-glass thermometers based on deep learning
Authors: Ding Guanzhi , Liang Zixi , Peng Shuisheng , Fan Changxiang , Guo Jing 
Published: November 2023

Abstract
The reading recognition system based on computer vision technology can improve the reading efficiency and accuracy of liquid-in-glass thermometers (LiGTs), and avoid the error caused by the human-eye reading method. Due to the requirement of a large field of view in the reading recognition process, the targets of LiGTs in the image are small and the accuracy of traditional computer vision (TCV) methods is undesirable. In addition, the potential shadow lines and the meniscus bottom on the image of LiGTs can also affect the robustness of the accuracy of the TCV methods. Around these issues, this paper develops an automatic reading recognition system for LiGTs based on deep learning, which aims to improve the accuracy of automatic reading recognition. Specifically, the cameras in our system are assisted in acquiring ideal images of LiGTs through the back-light illumination and lifting mechanism. Then a multi-task attention network and a general alignment processing module are designed for reading recognition on images of LiGTs. Experimental results on two self-built thermometer datasets prove that the system designed in this study can accurately recognize the temperature reading of LiGTs, and the performance of the proposed method outperforms other reading recognition methods.
On some collinear configurations in the planar three-body problem
Authors: Tsygvintsev Alexei 
Published: November 2023

AbstractIn this paper, we further investigate the planar Newtonian three-body problem with a focus on collinear configurations, where either the three bodies or their velocities are aligned. We provide an independent proof of Montgomery’s result (Montgomery 2007Ergod. Theory Dyn. Syst.27311–40), stating that apart from the Lagrange’s solution, all negative energy solutions to the zero angular momentum case result in syzygies, i.e. collinear configurations of positions. The concept of generalised syzygies, inclusive of velocity alignments, was previously explored by the author for bounded solutions in Tsygvintsev (2023C. R. Acad. Sci., Paris361331–5). In this study, we broaden our scope to encompass negative energy cases and provide new bounds. Our methodology builds upon the elementary Sturm–Liouville theory and the Wintner-Conley ‘linear’ form of the three-body problem, as previously explored in the works of Albouy and Chenciner (1997Invent. Math.131151–84); Albouy (2004Mutual Distances in Celestial Mechanics(Lectures at Nankai Institute)); Chenciner (2013Acta Math. Vietnam.38165–86).
Tuning quantum pathway interference in two-color laser photoemission using DC bias
Authors: Zhou Yang , Zhang Peng 
Published: November 2023

Abstract
Coherent control of quantum systems depends on the manipulation of quantum interference through external fields. In this work, we investigate the effects of DC bias field on coherent control of quantum pathways in two-color laser photoemission using exact analytical solutions of the one-dimensional time dependent Schrödinger equation. Increasing DC bias lowers and narrows the surface potential barrier, shifting the dominant emission to lower order multiphoton photoemission, photo-assisted tunneling and then direct tunneling. Those lower order photon absorption processes result in fewer possible pathways, and therefore modulation of photoemission current can be suppressed as DC field increases. It is shown that a maximum modulation depth of 99.4% can be achieved for a gold emitter at local DC bias F
0 = 0.5 V nm−1, fundamental (800 nm) laser field F
1 = 2.6 V nm−1 and second harmonic laser field F
2 = 0.25 V nm−1 . For a given set of input parameters, the total photoemission consists of different k-photon processes, each of which has their own different multiple possible pathways and interference effects. However, the quantum pathways and their interference for the dominant k-photon process and for the total photoemission probability show the same trends. This study demonstrates strong flexibility in tuning two-color lasers induced photoemission using a DC bias and provides insights into coherent control schemes of general quantum systems.