bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relativistic electron flux growth during storm and non-storm periods as observed by ARASE and GOES satellites
Authors: Belakhovsky Vladimir Borisovich , Pilipenko Vyacheslav A. , Antonova Elizaveta E. , Miyoshi Yoshizumi , Kasahara Yoshiya , Kasahara Satoshi , Higashio Nana , Shinohara Iku , Hori Tomoaki , Matsuda Shoya , Yokota Shoichiro , Takashima Takeshi , Takefumi Mitani , Keika Kunihiro , Nakamura Satoko 
Published: December 2023

AbstractVariations of relativistic electron fluxes (E ≥ 1 MeV) and wave activity in the Earth magnetosphere are studied to determine the contribution of different acceleration mechanisms of the outer radiation belt electrons: ULF mechanism, VLF mechanism, and adiabatic acceleration. The electron fluxes were measured by Arase satellite and geostationary GOES satellites. The ULF power index is used to characterize the magnetospheric wave activity in the Pc5 range. To characterize the VLF wave activity in the magnetosphere, we use data from PWE instrument of Arase satellite. We consider some of the most powerful magnetic storms during the Arase era: May 27–29, 2017; September 7–10, 2017; and August 25–28, 2018. Also, non-storm intervals with a high solar wind speed before and after these storms for comparison are analyzed. Magnitudes of relativistic electron fluxes during these magnetic storms are found to be greater than that during non-storm intervals with high solar wind streams. During magnetic storms, the flux intensity maximum shifts to lower L-shells compared to intervals without magnetic storms. For the considered events, the substorm activity, as characterized by AE index, is found to be a necessary condition for the increase of relativistic electron fluxes, whereas a high solar wind speed alone is not sufficient for the relativistic electron growth. The enhancement of relativistic electron fluxes by 1.5–2 orders of magnitude is observed 1–3 days after the growth of the ULF index and VLF emission power. The growth of VLF and ULF wave powers coincides with the growth of substorm activity and occurs approximately at the same time. Both mechanisms operate at the first phase of electron acceleration. At the second phase of electron acceleration, the mechanism associated with the injection of electrons into the region of the magnetic field weakened by the ring current and their subsequent betatron acceleration during the magnetic field restoration can work effectively.
Graphical Abstract
Metabolic disturbances potentially attributable to clogging during continuous renal replacement therapy
Authors: Müller Mattia M. , Caspar Larina , Sazpinar Onur , Hofmaenner Daniel A. , Erlebach Rolf , Andermatt Rea , Ganter Christoph C. , Schuepbach Reto A. , Wendel-Garcia Pedro D. , David Sascha 
Published: December 2023

AbstractBackgroundClogging is characterized by a progressive impairment of transmembrane patency in renal replacement devices and occurs due to obstruction of pores by unknown molecules. If citrate-based anti-coagulation is used, clogging can manifest as a metabolic alkalosis accompanied by hypernatremia and hypercalcemia, primarily a consequence of Na3Citrate infusion. An increased incidence of clogging has been observed during the COVID-19 pandemic. However, precise factors contributing to the formation remain uncertain. This investigation aimed to analyze its incidence and assessed time-varying trajectories of associated factors in critically ill patients on continuous renal replacement therapy (CRRT).MethodsIn this retrospective, single-center data analysis, we evaluated COVID-19 patients undergoing CRRT and admitted to critical care between March 2020 and December 2021. We assessed the proportional incidence of clogging surrogates in the overall population and subgroups based on the specific CRRT devices employed at our institution, including multiFiltrate (Fresenius Medical Care) and Prismaflex System (Baxter). Moderate and severe clogging were defined as Na > 145 or ≥ 150 mmol/l and HCO3− > 28.0 or ≥ 30 mmol/l, respectively, with a total albumin-corrected calcium > 2.54 mmol/l. A mixed effect model was introduced to investigate factors associated with development of clogging.ResultsFifty-three patients with 240 CRRT runs were analyzed. Moderate and severe clogging occurred in 15% (8/53) and 19% (10/53) of patients, respectively. Twenty-seven percent (37/136) of CRRTs conducted with a multiFiltrate device met the criteria for clogging, whereas no clogging could be observed in patients dialyzed with the Prismaflex System. Occurrence of clogging was associated with elevated triglyceride plasma levels at filter start (p = 0.013), amount of enteral nutrition (p = 0.002) and an increasing white blood cell count over time (p = 0.002).ConclusionsClogging seems to be a frequently observed phenomenon in critically ill COVID-19 patients. The presence of hypertriglyceridemia, combined with systemic inflammation, may facilitate the development of an impermeable secondary membrane within filters, thereby contributing to compromised membrane patency.
Flavor improving effects of cysteine in xylose–glycine–fish waste protein hydrolysates (FPHs) Maillard reaction system
Authors: Ding Yicheng , Yan Chen , Dai Wangli , Wang Yanbo , Liu Shulai , Zheng Renchao , Zhou Xuxia 
Published: December 2023

AbstractA promising way to utilize fish by-products is to develop hydrolysis of fish proteins with enzymes. The obtained fish protein hydrolysates (FPHs) are rich in peptides and amino acids, but bitterness and aroma defects impede further utilization of FPHs. The present study adopted Maillard reaction to improve FPHs’ flavor and illustrated the role of cysteine in this system. We investigated the impact of cysteine (0, 0.25%, 0.5%, 0.75%, and 1%) on the browning intensity, free amino acids (FAAs), molecular weight distribution, structure of MRPs, volatile compounds changes and organoleptic characteristics of xylose–glycine–FPHs Maillard reaction systems. Results showed that the addition of cysteine lowered the browning degree of Maillard reaction products (MRPs) by inhibiting the cross-linking of small peptides and reducing the production of melanin. GC–MS and GC–IMS analysis indicated that cysteine inhibited the formation of furans and nitrogen-containing compounds and facilitated the formation of sulfur-containing compounds contributing to the meaty flavor. Sensory analysis revealed that 0.25–0.75% range of cysteine increased the meaty, caramel, umami, mouthfulness and salty notes, and caused a decrease in bitter taste of the MRPs as confirmed by GC–MS. A highly significant correlation between the organoleptic characteristics and physicochemical indicators of MRPs was found by Mantel test. These results elucidated the influence of cysteine on the formation of Maillard reaction products and will help improve the flavor profile of meat flavorings.
Graphical Abstract
A Leader-follower formation control of mobile robots by position-based visual servo method using fisheye camera
Authors: Oh-hara Shinsuke , Fujimori Atsushi 
Published: December 2023

AbstractThis paper presents a leader-follower formation control of multiple mobile robots by position-based method using a fisheye camera. A fisheye camera has a wide field of view and recognizes a wide range of objects. In this paper, the fisheye camera is first modeled on spherical coordinates and then a position estimation technique is proposed by using an AR marker based on the spherical model. This paper furthermore presents a method for estimating the velocity of a leader robot based on a disturbance observer using the obtained position information. The proposed techniques are combined with a formation control based on the virtual structure. In this paper, the formation controller and velocity estimator can be designed independently, and the stability analysis of the total system is performed by using Lyapunov theorem. The effectiveness of the proposed method is demonstrated by simulation and experiments using two real mobile robots.
PRESERFLO MicroShunt implantation versus trabeculectomy for primary open-angle glaucoma: a two-year follow-up study
Authors: Gubser Pascal Aurel , Pfeiffer Valentin , Hug Simon , Shang Xiao , Lincke Joel-Benjamin , Häner Nathanael Urs , Zinkernagel Martin S. , Unterlauft Jan Darius 
Published: December 2023

Abstract
Background
To compare the intermediate-term efficacy of PRESERFLO (PF) MicroShunt implantation with trabeculectomy (TE) in patients with primary open-angle glaucoma, focusing on longitudinal changes of functional and structural parameters.

Methods
This retrospective comparative study included 104 eyes of 104 patients who underwent TE and 83 eyes of 83 patients that underwent PF implantation between January 2019 and December 2020, with a minimum follow-up of two years. Baseline and postoperative intraocular pressure (IOP), number of IOP-lowering medications, visual field mean defect (MD) and peripapillary retinal nerve fibre layer (RNFL) thickness measured using optical coherence tomography were assessed and compared between groups.

Results
Baseline characteristics (age, sex, IOP, number of IOP-lowering medications, MD, RNFL thickness) were comparable between the two groups (all P > 0.05). During the two-year of follow-up, mean IOP decreased from 24.09 ± 1.15 mmHg and 21.67 ± 0.77 mmHg to 11.37 ± 1.13 mmHg (P < 0.001) and 15.50 ± 1.54 mmHg (P = 0.028), and the mean number of IOP-lowering medications decreased from 3.25 ± 0.14 and 3.51 ± 0.14 to 0.53 ± 0.14 (P < 0.001) and 1.06 ± 0.43 (P < 0.001) in the TE and PF groups, respectively. MD remained stable [− 11.54 ± 0.93 dB and − 11.17 ± 1.66 to − 10.67 ± 0.91 dB (P = 0.226) and − 10.40 ± 4.75 dB (P = 0.628) in the TE and PF groups, respectively] but RNFL thickness decreased continuously during follow-up [62.79 ± 1.94 µm and 62.62 ± 2.05 µm to 57.41 ± 1.81 µm (P < 0.001) and 60.22 ± 1.98 µm (P = 0.182) in the TE and PF groups, respectively].

Conclusion
PF implantation is comparably effective in the intermediate term in lowering IOP and reducing the use of IOP-lowering medications over a two-year follow-up period. Although visual field defects were stable, RNFL continued to decrease during postoperative follow-up.
Fish oil users of Greece: reasons, appropriate use and perceived results regarding dietary supplement use
Authors: Soukiasian Panagiotis-David , Kyrana Zacharenia , Gerothanasi Konstantina , Kiranas Efstratios , Kokokiris Lambros E. 
Published: December 2023

AbstractThe aim of this cross-sectional study was to explore differences regarding the reasons, appropriate use, and perceived results relating to dietary supplement (DS) use between DS users who have used fish oils (FO) among other DS (DS + FO) and DS users who have used DS other than FO (DS − FO). Using a stratified random sampling technique, throughout 2018–2019, data was collected via in-person questionnaires. Having used any DS at least once, one was deemed a DS user, defined as “DS + FO” or “DS − FO” if FO were present or absent among the reported DS, respectively. The final sample consisted of 15,608 DS users. Independence between DS use status and categorical outcome variables was determined via Pearson’s chi-square test. Regarding DS users, 48.3 and 32.1% were medically supervised before and during DS use, respectively, with more DS + FO self-assessing themselves during, e.g., blood tests (21.6 vs. 17.1%). More DS + FO used DS systematically for > 1 month (42.9 vs. 30.8%) and selected more reasons for DS use (≥ 3; 47.6 vs. 25.4%). Most DS users experienced no negative outcomes from DS use (73.0%), but at least one positive outcome (95.8%), with DS + FO selecting a higher number of the latter (≥ 2; 55.7 vs. 38.0%). More DS + FO believed that a balanced diet (without DS) could not ensure their desired results (25.5 vs. 20.1%) but displayed a higher prevalence of recommended dietary allowance adherence (82.1 vs. 78.5%) and knowledge of the dangers of DS overuse (53.6 vs. 48.4%). Our study reveals significant differences between DS + FO and DS − FO with regard to their consumer stance and behavior towards DS.
Formal childcare services and fertility: the case of Italy
Authors: Scherer Stefani , Pavolini Emmanuele , Brini Elisa 
Published: December 2023

AbstractThis study aims at examining the fertility impact of early childhood education and care (ECEC) services for children under three in Italy. ECEC is a social investment-oriented family policy that might have more beneficial effects on fertility than passive support in terms of transfers. We first present a systematic review of studies regarding the impact of ECEC on fertility in high-income countries and then provide an empirical analysis for Italy, a country with lowest-low fertility rates and a welfare system that has traditionally provided limited support to families, especially through ECEC. We combine micro-level data from the Labour Force Survey for Italy from years 2003–2020 with information on regional indicators of public childcare and private childcare. The study employs within-region variation in ECEC over time to assess its effects on the transition to parenthood and parity progression for different groups of women and men. The present contribution indicates that both public and private childcare services have limited but positive short-term effects on fertility behaviour in Italy, contingent on specific socio-demographic groups. We discuss the possible reasons for the constrained effect of childcare on fertility and emphasise the necessity for more substantial and concerted interventions in Italy’s family policies if the aim is to invert demographic trends of lowest fertility and population-ageing.
Surgical accuracy of coronal and sagittal alignment in conventional closed-wedge high tibial osteotomy after computer-assisted surgery experience
Authors: Song Sang Jun , Bae Dae Kyung , Park Se Hwan , Park Cheol Hee 
Published: December 2023

Abstract
Background
Although intraoperative navigation can improve the surgeon’s proficiency, no studies have analyzed postoperative outcomes of high tibial osteotomy (HTO) after computer-assisted surgery (CAS) experience. The present study compared the clinical and radiographic results between conventional and CAS closed-wedge (CW) HTOs after CAS experience.

Methods
Each of the 50 conventional and CAS CW HTOs performed by single surgeon between 2015 and 2017 were included. The surgeon had experience of 140 cases of CAS CW HTOs before the study period. The groups were not different in terms of demographics. Clinically, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and range of motion (ROM) were investigated. Radiographically, the mechanical axis (MA), change in posterior tibial slope angle (PTS), and parallel angle were evaluated. The proportions of inlier groups for the postoperative MA (within valgus 2° ± 3°), change in the PTS (within ± 3°), and parallel angle (< 3°) were compared.

Results
There were no significant differences in postoperative clinical results between the conventional and CAS groups. The MA was appropriately corrected in both groups (2.4° versus 2.9°, p = 0.317). The amount of change in PTS was significantly greater in the conventional group (−2.2° versus −0.8°, p = 0.018). The parallel angle was 5.3° in the conventional groups and 3.1° in the CAS group (p = 0.003). The proportion of inlier group was not significantly different in the postoperative MA (72% versus 78%) and change in the PTS (52% versus 66%). The proportion of inlier for the parallel angle was significantly lower in the conventional group (36% versus 60%, p = 0.027).

Conclusions
The surgical proficiency after CAS experience could cover the advantages of an intraoperative navigation in coronal adjustment, not in the sagittal adjustments in CW HTOs. A larger cohort with multiple surgeons in multiple centers would be required to identify the general trend.

Study design
Level of evidence III.
Deep tissue super-resolution imaging with adaptive optical two-photon multifocal structured illumination microscopy
Authors: Zhang Chenshuang , Yu Bin , Lin Fangrui , Samanta Soham , Yu Huanhuan , Zhang Wei , Jing Yingying , Shang Chunfeng , Lin Danying , Si Ke , Gong Wei , Qu Junle 
Published: December 2023

AbstractVisualization of axons and dendritic spines is crucial in neuroscience research. However, traditional microscopy is limited by diffraction-limited resolution and shallow imaging depth, making it difficult to study neuronal dynamics. Two-photon multifocal structured illumination microscopy (2P-MSIM) provides super-resolution imaging along with a reasonably good penetration, but it is vulnerable to optical aberrations in deep tissues. Herein we present a novel non-inertial scanning 2P-MSIM system incorporated with adaptive optics (AO) which allows for super-resolution imaging with effective aberration correction. Our strategy is designed to correct both laser and fluorescence paths simultaneously using a spatial light modulator and a deformable mirror respectively, providing better results than the individual path corrections. The successful implementation of adaptive optical two-photon multifocal structured illumination microscopy (AO 2P-MSIM) has allowed for the super-resolution imaging of neuronal structures in a mouse brain slice at great depths and dynamic morphological characteristics of zebrafish motoneurons in vivo.
Generating 3D lithology probability volumes using poststack inversion, probabilistic neural networks, and Bayesian classification — A case study from the mixed carbonate and siliciclastic deposits of the Cisco Group of the Eastern Shelf of the Permian Basin, north-central Texas
Authors: Karakaya Sarp , Ogiesoba Osareni C. , Olariu Cornel , Bhattacharya Shuvajit 
Published: December 2023

The deposition and mixing of carbonates and siliciclastics in the Cisco Group of the Eastern Shelf of the Permian Basin are complicated by the temporal overlap between icehouse eustatic sea-level oscillations and fluctuations in sediment influx due to the rejuvenation of the Ouachita fold belt. Previous investigators have used well-log correlation as the primary tool in their interpretations of the area’s reciprocal depositional model, but well-log correlation alone cannot explain the full range of spatial lithology variations in the system. To better understand the lithology variation in the area, we use an integrated technique that combines wireline log information from 17 wells with 625 km2 3D seismic data through poststack seismic inversion, probabilistic neural networks (PNNs), and Bayesian classification. We use deterministic matrix inversion to derive lithology classes from well logs. Crossplot analyses reveal that the acoustic impedance and neutron porosity log pair can be used to differentiate lithologies. We perform model-based poststack inversion to generate a P-impedance volume and use PNNs to generate a neutron porosity volume. We combine these volumes through supervised Bayesian classification to generate lithology probability volumes for each lithology and a most probable lithology volume throughout the seismic data. The lithology volumes highlight the dominant lithologies (carbonate, shale, sand, and mixed) that allowed the interpretation of major carbonate platforms, sand-to-shale ratio variations, carbonate buildups between wells, and channel fill lithologies. Our semiautomated lithology detection workflow applies to regional studies and is also valid for reservoir-scale studies to determine variations in lithologies.
Long-Term Results of the Dasatinib-Blinatumomab Protocol for Adult Philadelphia-Positive ALL
Authors: Foà Robin , Bassan Renato , Elia Loredana , Piciocchi Alfonso , Soddu Stefano , Messina Monica , Ferrara Felicetto , Lunghi Monia , Mulè Antonino , Bonifacio Massimiliano , Fracchiolla Nicola , Salutari Prassede , Fazi Paola , Guarini Anna , Rambaldi Alessandro , Chiaretti Sabina 
Published: December 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. We report the long-term results of the frontline trial with dasatinib and blinatumomab in induction/consolidation (GIMEMA LAL2116, D-ALBA) for adult Philadelphia-positive ALL (Ph+ ALL), which enrolled 63 patients of all ages. At a median follow-up of 53 months, disease-free survival, overall survival, and event-free survival are 75.8%, 80.7%, and 74.6%, respectively. No events have occurred among early molecular responders. A significantly worse outcome was recorded for IKZF1 plus patients. Twenty-nine patients—93.1% being in molecular response (ie, complete molecular response or positive nonquantifiable) after dasatinib/blinatumomab—never received chemotherapy/transplant and continued with a tyrosine kinase inhibitor only; 28 patients remain in long-term complete hematologic response (CHR). An allogeneic transplant was carried out in first CHR mainly in patients with persistent minimal residual disease; 83.3% of patients are in continuous CHR. The transplant-related mortality was 12.5% for patients transplanted in first CHR and 13.7% overall. Nine relapses and six deaths have occurred. ABL1 mutations were found in seven cases. The final analysis of the D-ALBA study shows that a chemotherapy-free induction/consolidation regimen on the basis of a targeted strategy (dasatinib) and immunotherapy (blinatumomab) is effective in inducing durable long-term hematologic and molecular responses in adult Ph+ ALL, paving the way for a new era in the management of these patients.
Early-Pregnancy Serum Maternal and Placenta-Derived Exosomes miRNAs Vary Based on Pancreatic β-Cell Function in GDM
Authors: Razo-Azamar Melissa , Nambo-Venegas Rafael , Quevedo Iván Rafael , Juárez-Luna Gregorio , Salomon Carlos , Guevara-Cruz Martha , Palacios-González Berenice 
Published: December 2023

Abstract

Context
Pancreatic β-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal and placental responses during hyperglycemia. Studies have associated exosomal micro-RNAs (miRNAs) with GDM development. To date, no studies have been reported that evaluate the profile of miRNAs present in maternal and placental exosomes in the early stages of gestation from pregnancies that develop GDM.

Objective
We assessed whether early-pregnancy serum maternal and placenta-derived exosomes miRNA profiles vary according to pancreatic β-cell function in women who will develop GDM.

Methods
A prospective nested case–control study was used to identify exosomal miRNAs that vary in early-pregnancy stages (&lt;18 weeks of gestation) from women with normoglycemia and those who developed GDM based on their pancreatic β-cell function using the homeostasis model assessment of pancreatic β-cell function (HOMA-%β) index. Early-pregnancy serum maternal and placenta-derived exosomes were isolated to obtain miRNA profiles. Potential target and pathway analyses were performed to identify molecular and metabolic pathways associated with the exosomal miRNAs identified.

Results
In early-pregnancy stages, serum maternal exosome size and concentration are modified in GDM group and fluctuate according to HOMA-%β index. Serum maternal exosomal hsa-miR-149-3p and hsa-miR-455-3p in GDM are related to insulin secretion and signaling, lipolysis, and adipocytokine signaling. Early-pregnancy serum placenta-derived exosomes hsa-miR-3665 and hsa-miR-6727-5p in GDM are related to regulating genes involved in response to immunological tolerance of pregnancy and pathways associated with placental dysfunction.

Conclusion
Early serum exosomal miRNAs differ depending on their origin (maternal or placental) and pancreatic β-cell function. This research provides insights into the interactions between maternal and placental exosomal miRNAs and may have implications for identifying potential biomarkers or therapeutic targets for GDM.