bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Experimental Study of High-Density Drilling and Workover Fluids
Authors: Al Moajil Abdullah. M. , Alghizzi Ahmed. G. , Caliskan Sinan. , Almubarak Tariq 
Published: February 2024

Abstract
Comparative assessment experimental study was conducted for high density NaBr and CaCl2/CaBr2 brines and water-drilling fluids based on manganese tetraoxide and barite as weighting agents. The main objective of this study were to evaluate the core damage caused by such drilling/workover fluids.
XRD/XRF were used to determine the composition of the core plug samples. CT scan was utilized to assess the effect of workover fluids, workover brines, and acid recipe on fluid invasion profile. The mudloop system was exploited to expose core plugs to workover fluids and assess the effectiveness of treatment recipes in restoring core plug permeability at 280°F. Filter press was used to generate filter cake and assess fluid filtration rates. Solubility testing was conducted using HCl/formic and DTPA-based recipes with mud cakes generated at 280°F
The solubility of the filter cake generated by water-based drilling fluids weighed with BaSO4, mixture of BaSO4\Mn3O4, and Mn3O4 were 40, 65, and 85 wt%, respectively in 5 wt% HCl/9 wt% formic acid mixture. DTPA-based recipe increased the barite-based filter cake solubility from 40 to 60 wt%. The observed reduction in dolomite core plug permeability was a stronger function of core plug characterization than drilling fluid type. The core damage was higher in heterogeneous core plugs samples. The core damage increased with drilling fluid filtrate volume, regardless of the drilling fluid type. Coreflood and CT scan testing indicated the examined manganese tetroxide water-based drilling fluid was less damaging to core plug samples than barite water-based drilling fluid. The factor controlling acid propagation into core plug was not reaction limited. Acid propagated in the flow direction where higher permeable steaks exist. Acid propagation and drilling fluid invasion profiles were a function of core plug characteristics. The core damage caused by CaCl2/CaBr2 brines were significantly higher than NaBr brine. The injection of low salinity brine removed the core damage caused by heavy brines (i.e., precipitated salts).
Improved Completions and Fracturing Technology Enhances Efficiency and Sustained Oil and Gas Production
Authors: Rahim Zillur , Watson Mark , Wilson Stuart , Barbero Pablo 
Published: February 2024

Abstract
To attain higher hydrocarbon production and maintain oil and gas rates at optimal values for a determined time require prudent drilling, and subsequently completing and fracturing the well. are some of the essential criteria for positive cash flow.
Oil and gas production is essential to meet world energy demand. The objective of any hydrocarbon field development is to attain higher sustained production rates. The need for the use of best practices in drilling, completion, fracturing, and production management during the duration of a well becomes essential. Drilling of long horizontal laterals through the reservoir section has been a game-changing alternate to vertical wells. Production is substantially increased with horizontal wells; long-term sustainability is achieved and development cost is considerably reduced.
This paper highlights state of the art completions and fracturing technology used in moderate to tight oil and gas reservoirs for enhanced and sustained productivity. After proper assessment of the field using data from geoscience, delineation wells, and logs, an optimal horizontal drilling design is put together. Wells drilled in the field can be completed in multiple ways depending on the reservoir properties, well trajectory, and production objectives. The best completions are those that are customized for the reservoir parameters and well trajectory and will provide optimal inflow of reservoir fluids to the well. The best fracturing technique is to place a high conductivity path between the well and reservoir without causing damage to either the reservoir or completions. Depending on the reservoir, acid or proppants are selected such that fracture conductivity is maintained through most of well life. Many examples are provided in this paper.
Coupled Adsorption/Precipitation Modelling of Phosphonate Scale Inhibitors in a Batch Reactive System
Authors: Meybodi M. Kalantari , Sorbie K. S. , Vazquez O. , Jarrahian K. , Mackay E. J. 
Published: February 2024

Abstract
Scale inhibitor squeeze treatments are one of the most common ways to prevent scale deposition. The mineral scale will be inhibited if the concentration of the scale inhibitor (SI) in the produced water is above a certain threshold, known as the Minimum Inhibitor Concentration (MIC), which is controlled by scale inhibitor retention. Therefore, accurate modelling of the SI retention through adsorption (Γ) and precipitation (Π&#x90;) is critical to the successful design and implementation of squeeze treatments.
In this study, an equilibrium model has been developed to simulate the coupled adsorption-precipitation (Γ&#x90;/Π&#x90;) of phosphonate scale inhibitors in reactive formations, such as carbonates, in the presence of calcium and magnesium cations. In this approach, the scale inhibitor (SI) was considered as a poly weak acid that may be protonated (HnA), resulting in the complexation with Ca/Mg ions, leading to the precipitation of SI_Ca/Mg complexes. All these reactions occur in an integrated system where carbonate system reactions and adsorption of the soluble species are occurring in parallel.
In the adsorption process, all the SI derivatives remaining in the solution, including free and complex species, are considered to participate in the adsorption process, described by an an adsorption isotherm model (e.g., Freundlich). For the precipitation part, the model considers the following reactions: (i) the carbonate system, (ii) SI speciation, considered as weak polyacid, HnA, (iii) the SI-metal (Ca and Mg) binding complexes, and (iv) subsequent precipitation of the SI-Ca/Mg complex. The system charge balance and the mass balances for calcium, magnesium, carbon, and SI are considered, to numerically equilibrate the system (excluding the adsorbed species), by solving a determined set of non-linear equations numerically. Following the algebraic reduction of the equations, the system is reduced to three non-linear equations that may be solved by the Newton-Raphson method. The precipitation of the SI-Ca/Mg is modelled in the equilibrium model based on the solubility of SI in the solution, determined from the lab experiments.
The reliability of the proposed model was established by comparison with experimental results from a previous study (Kalantari Meybodi et al., 2023) on the interactions of DETPMP in a Calcite/brine (containing free Ca/Mg) system, where the final concentration of SI, Ca2+, Mg2+, CO2 and pH were compared. The modelling showed good general agreement with the experimental results, and a further sensitivity analysis was performed to examine the behaviour of some uncertain parameters, such as the stability constant of complexes.
DPC-seq enables genome-wide monitoring of DNA-protein crosslink induction and repair
Authors: Bader Aldo S. , Erdenebat Chimeg , Acampora Aleida C. , Carnie Christopher J. , Jackson Stephen P. , Stingele Julian 
Published: February 2024

Abstract
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions arising from a variety of endogenous and exogenous genotoxins including chemotherapeutic drugs. DPCs can be enzymatic or non-enzymatic in nature, with non-enzymatic DPCs arising from endogenous aldehydes such as formaldehyde constituting a potentially significant source of endogenous DNA damage. Mechanistic studies of non-enzymatic DPC repair have been hampered by the fact that any chromatin-associated protein could feasibly become crosslinked to DNA, making it challenging to assess the impact of genomic context on DNA induction and repair by conventional methods such as ChIP-seq. Here, we describe DPC-seq, a protocol by which researchers can purify and sequence genomic DNA that bore DPCs, where sequencing read coverage can be used to infer DPC occupancy at specific genomic loci.
Myeloid-Derived Suppressor Cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection
Authors: Pencovich Niv , Nachmany Ido , Edelheit Sarit , Friedlander Gilgi , Yakubovsky Oran 
Published: February 2024

Abstract

Introduction:
Liver regeneration following resection is a complex process relying on coordinated pathways and cell types in the remnant organ. Myeloid-Derived Suppressor Cells (MDSCs) have a role in liver regeneration-related angiogenesis but their influence on hepatocyte proliferation and immune modulation during liver regeneration is unclear.
Methods
We examined the transcriptional response of regenerating liver hepatocytes after major resection in mice with CD11b+Ly6G+ MDSCs (G-MDSCs) depletion using RNA sequencing. Immune changes within regenerating livers post-resection upon MDSC depletion were assessed via cytometry by time-of-flight (CyTOF).
Results
Global gene expression profiling of regenerating hepatocytes upon G-MDSC depletion revealed disrupted transcriptional progression from day one to day two after major liver resection. Key genes and pathways related to hepatocyte proliferation and immune response were differentially expressed upon MDSC depletion. CyTOF analysis of intra-liver immune milieu upon MDSC depletion in regenerating livers post-resection demonstrated marked increases in natural killer cell and activated T cell proportions, alongside changes in other immune cell populations.
Conclusions
This study provides evidence that MDSCs contribute to early liver regeneration by promoting hepatocyte proliferation and modulating the intra-liver immune response. These findings illuminate the multifaceted role of MDSCs in liver regeneration.
Optimal pulse harvesting strategy based on uncertain Gompertz population model
Authors: Song Luben , Sheng Yuhong 
Published: February 2024

Abstract
Based on the basic principles of the renewal process and α-paths, uncertain Gompertz population equation and optimal pulse harvesting strategy of uncertain Gompertz population equation are proposed in this paper. It is a differential equation of uncertain population model driven by canonical Liu process. First of all, the solution of Gompertz population equation with uncertainty is proposed for the first time. Whereafter, the uncertainty distribution and α-paths are given. Based on the basic principles of the renewal process, we study the population number following the uncertain Gompertz population equation, calculate the first hitting time when it reaches the preset level, design an accurate harvesting strategy which could be transformed into an problem of the maximum value of two variables.
Differential responses in recovery, growth and survival between intertidal and subtidal corals after acute thermal stress
Authors: Almeida Luis , Osinga Ronald , Knoester Ewout Geerten 
Published: February 2024

Abstract

Sea temperature increases may compromise ecological restoration as a tool for recovering degraded coral reefs. A potential solution may lay within using corals with naturally higher thermal resilience, such as intertidal corals. This study aimed at comparing thermal resilience, growth and survival between intertidal and subtidal corals in a reciprocal transplant experiment. Sixty coral nurseries were installed in a shallow coral reef area in Kenya: half were placed in the intertidal zone and half in the subtidal zone. At both zones, intertidal and subtidal Pocillopora cf damicornis coral fragments were cultured in equal proportions, resulting in 15 replicate nurseries for four treatments. After an initial culture phase of 1 month in situ, six nurseries per treatment were thermally stressed ex situ by exposing corals for 5 days to a temperature of 32°C (3°C above summer maximum), after which they were returned in situ to recover. Fragment brightness was measured as the response variable to thermal stress. Intertidal and subtidal corals increased brightness (i.e., bleached) at a similar rate, but during recovery intertidal corals returned quicker to their original brightness in both culture environments. Coral growth was highest for intertidal corals in the intertidal zone during cooler months and was highest for subtidal corals in the subtidal zone during peak temperatures. Intertidal corals transplanted to the subtidal zone registered the lowest survival. Thus, intertidal corals display higher thermal resilience through quicker recovery, but potential trade-offs require further investigation before these corals can be used as a climate-proof broodstock for reef restoration.
Clinically Validated Classification of Chronic WoundsMethod with Memristor-Based Cellular Neural Network
Authors: Secco Jacopo , Spinazzola Elisabetta , Pittarello Monica , Ricci Elia Bernardino , Pareschi Fabio 
Published: February 2024

Abstract

Chronic wounds are a syndrome that affects around 4% of the world population due to several pathologies. The COV-19pandemic has enforced the need of developing new techniques and technologies that can help clinicians to monitor the affectedpatients easily and reliably. In this study a new device, the Wound Viewer (WV), that works through a memristor-basedDiscrete-Time Cellular Neural Network (DT-CNN) has been developed and tested through a clinical trial of 150 patients. TheWV has been developed to serve as the state-of-art tool, capable to return the actual clinical information that is most neededby the caregivers. This work aims to describe in depth the technology and the computational techniques that have beenimplemented, and to demonstrate reliability in automatically identifying, classifying through internationally accepted clinicalscales and measuring such wounds, that peaked to over a 90% of accuracy.
Dietary vitamin D is a novel modulator of tumor engraftment through regulation of GC protein abundance.
Authors: Danahy Lo , Long Caela , Hofmann Ted J. , Tara Zahra , Mark Julian , Roizen Jeffrey D. 
Published: February 2024

Abstract

The vitamin D binding protein, the GC protein, is a multifunctional protein that binds circulating vitamin D and also increases macrophage killing of tumor cells. Injecting exogenous GC protein concurrent with experimental tumor implant decreases tumor engraftment rate. Until now serum abundance of this protein was thought to be controlled by estrogen, glucocorticoids and inflammatory cytokines, but, not by vitamin D itself(1, 2). Nonetheless, increasing dietary vitamin D is thought to increase serum vitamin D, which is 98% bound by the GC protein. Based on the protection that excess GC protein offers we sought to determine if decreased GC protein abundance might decrease tumor immunity. Relatedly, we theorized, by contrast to the current model, that dietary vitamin D might affect serum abundance of GC protein. If exogenous vitamin D alters available GC levels, then this effect might indicate a novel pathway by which vitamin D enhances immunity. To examine these possibilities, we examined the effect of GC protein absence on tumor persistence or engraftment on two different and common tumor types (prostate cancer and breast cancer). We further examined the relationship between dietary vitamin D and serum GC abundance. We found that absence of GC protein allowed significantly more engraftment of breast tumor cells in female mice and of prostate tumor cells in male mice. Further, we found a U-shaped response of serum GC protein to dietary vitamin D dosage as well as to serum vitamin D, indicating the potential benefit of high exogenous doses to enhance immunity and reduce tumor burden.
Association of spirituality and quality of life in cancer survivors: A systematic review and meta- analysis
Authors: Firkins Jenny L. , Tomic Ivana , Hansen Lissi , Woodrell Christopher D. 
Published: February 2024

Abstract
Purpose:
Cancer is a leading cause of morbidity and mortality worldwide. Although people are living longer with cancer, cancer has the potential to negatively impact survivors’ quality-of-life (QOL). Spirituality encompasses the concepts of transcendence, meaningfulness, faith, connectedness, and integrative energy. Spirituality is a part of everyday existence across cultures and religions and is a part of the human experience. Yet little has been published on spirituality in cancer survivorship. We were unable to find any previous reviews that examined the literature on the potential relationship between QOL and spirituality in cancer survivorship. Thus the aim of this systematic review and meta-analysis is to examine the current literature to more fully understand the relationship between spirituality and QOL.
Methods:
Using PRISMA guidelines, a systematic review and meta-analysis were conducted to examine the relationship between spirituality and QOL in cancer survivorship in studies sourced from PubMed, CINHAL, and PsycINFO databases.
Results:
Twenty-four articles, published between 2005 and 2023 were included for review. All studies included demonstrated a significant, positive correlation between QOL and spirituality with r values ranging from 0.15 to 0.817.
Conclusion:
Our findings suggest a positive correlation between higher spirituality and increased QOL among cancer survivors. Future research is needed to improve the understanding of this relationship and its mediators so that supportive oncologic interventions can be modified to address unmet needs and spiritual suffering. By better understanding the relationship between spirituality and QOL, we can move towards supporting the highest level of QOL possible for cancer survivors.
WITHDRAWN: Analysis of Clinical and Demographic Characteristics among Turkish Patients with Neurofibromatosis Type 1, with a Focus on Dermatological Features
Authors: Ahmadi Vahid , Karimi Nazli , Evans Sibel Ersoy , Karaduman Ayşen 
Published: February 2024

Abstract
The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Generalized and COVID related anxiety as risk factors for health outcomes among adolescents with HIV during COVID-19 in Tanzania
Authors: Siril Hellen , Gitagno David , Kaaya Sylvia , Caputo Matthew , Hirschhorn Lisa , Nyamuhanga Tumaini , Mtei Rachel , Festo Charles , Hawkins Claudia 
Published: February 2024

Abstract

The COVID-19 pandemic and associated prevention strategies caused widespread interruptions to care and treatment for people living with HIV. Adolescents living with HIV (AWHIV) were particularly vulnerable to poor mental and physical health during COVID-19. We assessed the burden of generalized and COVID-19–related anxiety and associations with adherence to HIV care and treatment and viral load suppression (VLS) among AWHIV during the peak of the COVID-19 pandemic in Tanzania. Methods This cross-sectional study was conducted among AWHIV aged 15–19 years attending 10 clinics in Dar es Salaam from April 2022-February 2023. Study participants completed a self-administered questionnaire including Generalized Anxiety Disorder (GAD), COVID-19-related anxiety, and other psychosocial and physical health and support measures. HIV visit adherence, viral load and sociodemographic data were abstracted from patient health records.Analysis: Multivariable (MV) quasibinomial and logistic regression models examined associations of Generalized and COVID-19-related anxiety with visit adherence and HIV virologic suppression (HIV VL < 50 copies/mL). Data were analyzed using R software. Results 658 AWHIV (52% male) were included in this analysis. Most (86%) had been on antiretroviral treatment (ART) for at least four years, 55% attended at least 75% of their scheduled clinic visits, and 78% were HIV virologically suppressed. The median GAD and COVID-19-related anxiety scores were 2 (IQR: 0–5, and 26 (IQR: 13–43; respectively. Only 2% scored moderate-severe generalized anxiety (score 10–21). We found no significant associations between COVID-19-related anxiety or GAD and visit adherence. Higher GAD was inversely associated with VLS (adjusted odds ratio (AOR): 0.89 (95% CI 0.81, 0.98)). Female gender and higher quality of physical life were significantly associated with VLS.Conclusion. Low levels of generalized and COVID-19 related anxiety were reported among Tanzanian AWHIV. Integrating screening and management of generalized anxiety screening into HIV care for AWHIV could improve VLS among this population.
Sequential GP-UCB Bayesian Optimization for Deep Neural Network Fine-Tuning in Dissolved Oxygen Prediction
Authors: Garabaghi Farid Hassanbaki , Benzer Semra , Benzer Recep 
Published: February 2024

Abstract
Dissolved Oxygen (DO) is a key indicator of water quality, essential for sustaining aquatic ecosystems and human uses. Machine learning, particularly deep learning, is recognized as an effective approach for predicting DO levels by learning from data rather than requiring explicit human knowledge input. The effectiveness of deep learning models improves with fine-tuning of hyperparameters. Amongst hyperparameter tuning methods, Bayesian methods have gained particular interest for optimization. This study focuses on predicting DO levels in riverine environments using a Deep Neural Network model. The research employs a Gaussian Process Upper Confidence Bound (GP-UCB) Bayesian optimization technique to fine-tune hyperparameters, aiming for an optimal configuration. Comparative analysis is conducted between the optimized model and baseline model with default settings. Results indicate that the Bayesian-optimized model outperforms the baseline, particularly evident with moderately sized datasets. The findings underscore the pivotal role of Bayesian optimization in elevating model performance, exhibiting robust generalization capabilities while significantly reducing the need for manual parameter tuning. This successful application underscores a substantial methodological advancement in environmental management, particularly in predictive modelling for indicators of aquatic ecosystem health.