bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Cross-Correlation on the Modelled Uncertainty in Stress–Strain Behavior of Soft Clays
Authors: Löfman Monica Susanne , Korkiala-Tanttu Leena Katariina 
Published: February 2024

AbstractReliability-based design is increasingly being applied to geotechnical problems because it allows the robust consideration of various sources of uncertainty, such as the inherent variability of soil properties. Some soil properties, however, are mutually dependent, and ignoring this cross-correlation may lead to biased estimates of the probability of unsatisfactory performance. Hence, in this study, the Gaussian copula was used to evaluate how the applied cross-correlation or independence between the compressibility properties affects the uncertainty in the stress–strain response of two marine soft clays. Two settlement calculation methods were considered: the compression index and Janbu tangential stiffness methods. The correlation coefficients were defined from the site-specific oedometer data at two extensively studied clay sites, and from a database. The simulated oedometer curves were compared to the observed variability in the site-specific data. The settlements in the clay sublayers were then computed, and different cases were compared by means of boxplots. It is concluded that the Janbu method leads to a significant overestimation of uncertainty in settlement if the cross-correlation between the compressibility parameters is ignored. On contrary, the compression index method seems less sensitive to the assumed correlation structure, and as such, the parameters can be treated as independent in most cases.
A Multi-Criteria Decision-Making Framework to Evaluate the Impact of Industry 5.0 Technologies: Case Study, Lessons Learned, Challenges and Future Directions
Authors: Abdel-Basset Mohamed , Mohamed Rehab , Chang Victor 
Published: February 2024

AbstractSmart technologies have demonstrated striking outcomes regarding the early diagnosis of diseases and the delivery of the necessary healthcare in the last decade. However, by emphasizing the core fundamentals of social justice and sustainability, together with digitalization and smart technologies that predicate raising productivity and flexibility, Industry 5.0 has proven to achieve more efficient results. Industry 5.0 technologies provide more intelligent ways for human employees and higher efficiency development while also improving safety and performance in many applications. In this research, the contribution is focused on the healthcare and how Industry 5.0 technologies demonstrate several advantages for the healthcare sector, starting with automated and precise disease prediction, moving on to aiding medical personnel in continual surveillance and monitoring and concluding with successful digital automation of smart equipment. The objective of this study is to apply a hybrid multi-criteria decision-making approach under a neutrosophic environment to evaluate the advantages of industry 5.0 technologies in the healthcare sector. Industry 5.0 primary value is to reach human-centric, sustainable, and resilient industries. While Industry 5.0 technologies sub-values regarding the healthcare sector are determined and distinguished according to the 3-main values mentioned previously based on literature. The methodologies applied in this study are: The Analytical Hierarchy approach (AHP) evaluates the main values and sub-values. Subsequently, the effectiveness of industry 5.0 technologies according to their values to the healthcare sector are ranked by Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). The approach is constructed under uncertainty based on a neutrosophic environment to achieve accuracy in the evaluation process. The results show that the most influential technology in healthcare are AI and cloud computing, while nano-technology, drone technology, and robots are at the end of the ranking. While validating the suggested technique, outcome comparisons were carried out to demonstrate the benefits of the methodologies. A sensitivity study indicates that adjusting the weightings of the sub-values has no significant effect on the ranking of technologies.
Investigation of Terp-Pyr/p-Si diode using complex impedance spectroscopy depending on measurement temperatures and frequencies
Authors: Oruç Pınar , Eymur Serkan , Tuğluoğlu Nihat 
Published: February 2024

AbstractA unique Al/Terp-Pyr/p-Si/Al diode structure that has not before been presented was introduced in this paper. Utilizing capacitance-conductance-frequency (C-G-f) characteristics in the frequency range of 20 Hz− 1.5 MHz for four temperatures of 300 K, 325 K, 350 K, and 375 K, admittance analysis was carried out to disclose the impedance and dielectric properties of the diode. The appearance of interface states at the Terp-Pyr/p-Si interface leads to an increase in capacitance values at low frequencies. Using complex impedance spectroscopy, the impedance characteristics of the Al/ Terp-Pyr/p-Si/Al Schottky diode were examined. The fabricated diode’s dielectric, modulus, and ac conductivity properties were investigated in the same frequency and temperature range. It has been revealed that while $${\epsilon }^{{\prime }}$$

ϵ

′

decreases up to high frequencies for all temperatures, it grows with temperature in the low-frequency zone. It becomes apparent that while the real component (M’) of modulus grows for all temperatures from low to high frequencies, it decreases at high frequencies as temperature rises. remarkably adjustable temperature, voltage, and frequency tuning of the dielectric constants $$({\epsilon }^{{\prime }},{{\epsilon }^{{\prime }}}^{{\prime }})$$

(

ϵ

′

,

ϵ

′

′

)

and dielectric loss tangent (tanδ). Additionally, the equivalent circuit of the Al/ Terp-Pyr/p-Si/Al Schottky diode and Cole-Cole diagrams were explored.
Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk–benefit analysis
Authors: Alhalabi Obada T. , Dao Trong Philip , Kaes Manuel , Jakobs Martin , Kessler Tobias , Oehler Hannah , König Laila , Eichkorn Tanja , Sahm Felix , Debus Jürgen , von Deimling Andreas , Wick Wolfgang , Wick Antje , Krieg Sandro M. , Unterberg Andreas W. , Jungk Christine 
Published: February 2024

Abstract
Purpose
Surgery for recurrent glioma provides cytoreduction and tissue for molecularly informed treatment. With mostly heavily pretreated patients involved, it is unclear whether the benefits of repeat surgery outweigh its potential risks.

Methods
Patients receiving surgery for recurrent glioma WHO grade 2–4 with the goal of tissue sampling for targeted therapies were analyzed retrospectively. Complication rates (surgical, neurological) were compared to our institutional glioma surgery cohort. Tissue molecular diagnostic yield, targeted therapies and post-surgical survival rates were analyzed.

Results
Between 2017 and 2022, tumor board recommendation for targeted therapy through molecular diagnostics was made for 180 patients. Of these, 70 patients (38%) underwent repeat surgery. IDH-wildtype glioblastoma was diagnosed in 48 patients (69%), followed by IDH-mutant astrocytoma (n = 13; 19%) and oligodendroglioma (n = 9; 13%). Gross total resection (GTR) was achieved in 50 patients (71%). Tissue was processed for next-generation sequencing in 64 cases (91%), and for DNA methylation analysis in 58 cases (83%), while immunohistochemistry for mTOR phosphorylation was performed in 24 cases (34%). Targeted therapy was recommended in 35 (50%) and commenced in 21 (30%) cases. Postoperatively, 7 patients (11%) required revision surgery, compared to 7% (p = 0.519) and 6% (p = 0.359) of our reference cohorts of patients undergoing first and second craniotomy, respectively. Non-resolving neurological deterioration was documented in 6 cases (10% vs. 8%, p = 0.612, after first and 4%, p = 0.519, after second craniotomy). Median survival after repeat surgery was 399 days in all patients and 348 days in GBM patients after repeat GTR.

Conclusion
Surgery for recurrent glioma provides relevant molecular diagnostic information with a direct consequence for targeted therapy under a reasonable risk of postoperative complications. With satisfactory postoperative survival it can therefore complement a multi-modal glioma therapy approach.
GraphSAGE++: Weighted Multi-scale GNN for Graph Representation Learning
Authors: Jiawei E. , Zhang Yinglong , Yang Shangying , Wang Hong , Xia Xuewen , Xu Xing 
Published: February 2024

AbstractGraph neural networks (GNNs) have emerged as a powerful tool in graph representation learning. However, they are increasingly challenged by over-smoothing as network depth grows, compromising their ability to capture and represent complex graph structures. Additionally, some popular GNN variants only consider local neighbor information during node updating, ignoring the global structural information and leading to inadequate learning and differentiation of graph structures. To address these challenges, we introduce a novel graph neural network framework, GraphSAGE++. Our model extracts the representation of the target node at each layer and then concatenates all layer weighted representations to obtain the final result. In addition, the strategies combining double aggregations with weighted concatenation are proposed, which significantly enhance the model’s discernment and preservation of structural information. Empirical results on various datasets demonstrate that GraphSAGE++ excels in vertex classification, link prediction, and visualization tasks, surpassing existing methods in effectiveness.
Modulation of the wheat transcriptome by TaZFP13D under well-watered and drought conditions
Authors: Bouard William , Ouellet François , Houde Mario 
Published: February 2024

AbstractMaintaining global food security in the context of climate changes will be an important challenge in the next century. Improving abiotic stress tolerance of major crops such as wheat can contribute to this goal. This can be achieved by the identification of the genes involved and their use to develop tools for breeding programs aiming to generate better adapted cultivars. Recently, we identified the wheat TaZFP13D gene encoding Zinc Finger Protein 13D as a new gene improving water-stress tolerance. The current work analyzes the TaZFP13D-dependent transcriptome modifications that occur in well-watered and dehydration conditions to better understand its function during normal growth and during drought. Plants that overexpress TaZFP13D have a higher biomass under well-watered conditions, indicating a positive effect of the protein on growth. Survival rate and stress recovery after a severe drought stress are improved compared to wild-type plants. The latter is likely due the higher activity of key antioxidant enzymes and concomitant reduction of drought-induced oxidative damage. Conversely, down-regulation of TaZFP13D decreases drought tolerance and protection against drought-induced oxidative damage. RNA-Seq transcriptome analysis identified many genes regulated by TaZFP13D that are known to improve drought tolerance. The analysis also revealed several genes involved in the photosynthetic electron transfer chain known to improve photosynthetic efficiency and chloroplast protection against drought-induced ROS damage. This study highlights the important role of TaZFP13D in wheat drought tolerance, contributes to unravel the complex regulation governed by TaZFPs, and suggests that it could be a promising marker to select wheat cultivars with higher drought tolerance.
Trace Operator on von Koch’s Snowflake
Authors: Kazaniecki Krystian , Wojciechowski Michał 
Published: February 2024

AbstractWe study properties of the boundary trace operator on the Sobolev space $$W^1_1(\Omega )$$

W
1
1

(
Ω
)

. Using the density result by Koskela and Zhang (Arch. Ration. Mech. Anal. 222(1), 1-14 2016), we define a surjective operator $$Tr: W^1_1(\Omega _K)\rightarrow X(\Omega _K)$$

T
r
:

W
1
1

(

Ω
K

)

→
X

(

Ω
K

)

, where $$\Omega _K$$

Ω
K

is von Koch’s snowflake and $$X(\Omega _K)$$

X
(

Ω
K

)

is a trace space with the quotient norm. Since $$\Omega _K$$

Ω
K

is a uniform domain whose boundary is Ahlfors-regular with an exponent strictly bigger than one, it was shown by L. Malý
(2017) that there exists a right inverse to Tr, i.e. a linear operator $$S: X(\Omega _K) \rightarrow W^1_1(\Omega _K)$$

S
:
X

(

Ω
K

)

→

W
1
1

(

Ω
K

)

such that $$Tr \circ S= Id_{X(\Omega _K)}$$

T
r
∘
S
=
I

d

X
(

Ω
K

)

. In this paper we provide a different, purely combinatorial proof based on geometrical structure of von Koch’s snowflake. Moreover we identify the isomorphism class of the trace space as $$\ell _1$$

ℓ
1

. As an additional consequence of our approach we obtain a simple proof of the Peetre’s theorem (Special Issue 2, 277-282 1979) about non-existence of the right inverse for domain $$\Omega $$
Ω
with regular boundary, which explains Banach space geometry cause for this phenomenon.
A Fourier Integral Formula for Logarithmic Energy
Authors: Frerick L. , Müller J. , Thomaser T. 
Published: February 2024

AbstractA formula which expresses logarithmic energy of Borel measures on $$\mathbb {R}^n$$

R

n

in terms of the Fourier transforms of the measures is established and some applications are given. In addition, using similar techniques a (known) formula for Riesz energy is reinvented.
A cone-beam computed tomography study of canalis sinuosus and its accessory canals in a South African population
Authors: Beckenstrater Michael A. , Gamieldien Mohamed Y. , Smit Chane , Buchanan Glynn D. 
Published: February 2024

Abstract
Objectives
Canalis sinuosus (CS) is a clinically relevant structure in the anterior maxilla. The present study aimed to determine the prevalence and distribution of CS and its accessory canals (ACs) in the South African population and describe its anatomical variations.

Methods
In total, 500 cone-beam computed tomography (CBCT) scans of the anterior maxilla were assessed for prevalence, sidedness, diameter, and distribution of CS. The frequency, number, diameter, configuration, and point of termination of ACs were also recorded. Statistical analysis was performed using analysis of variance, Kruskal–Wallis, chi-squared, and Fisher Exact tests with P < 0.05.

Results
CS was present in most cases (99.6%), and commonly occurred bilaterally (98.8%). The mean diameter of CS was 1.08 mm (range: 0.50 mm–2.39 mm). Sex, population group, and age had no significant effect on the prevalence or sidedness of CS. Additionally, 535 ACs were observed in 58.8% of the sample, with 42.9% of ACs found bilaterally and 57.1% unilaterally. The mean diameter of the ACs was 0.86 mm on the left and 0.87 mm on the right (range; 0.50 mm–1.52 mm). The majority of ACs maintained a straight vertical configuration (72.3%). ACs most commonly terminated in the anterior palatal region of the maxilla (57.2%). No significant differences were found in any groups mentioned (P > 0.05).

Conclusions
A high prevalence of CS as well as ACs were observed in the sample population. Due to their clinical significance, surgical planning with the aid of high quality CBCT scans of the anterior maxilla is advisable.
Monitoring air quality of Sharkia Governorate using remote sensing
Authors: Nagy Alaa , El-Zeiny Ahmed , Sowilem Mohamed , Moselhi Walaa , Elshaier Manal 
Published: February 2024

AbstractDue to Sharkia population’s rapid growth, the crises of atmospheric pollutants are causing significant concern. These circumstances have positive and negative impacts on both environment and climate. This research aims to investigate and evaluate changes in land and air characteristics of the governorate using remotely sensed data from several satellites (Landsat, Aqua, Terra, and Sentinel-5P) in conjunction with geographic information system (GIS) techniques. Three multitemporal Landsat images were acquired in July 2002, 2012, and 2022, to monitor land use/land cover (LULC) changes during the past 20 years. In addition, aerosol optical depth (AOD) data were obtained daily over 2022, and Particulate Matter (PM2.5) was calculated and then averaged seasonally. Sentinel-5P was utilized for CO, NO2, and SO2 retrievals. Results showed that the governorate was continuously subjected to spatiotemporal changes in LULC during the whole study period. It was mainly occupied by vegetation with a total area of 3711.64, 3851.05, and 3794.59 km2 in 2002, 2012, and 2022, respectively. Seasonal means of PM2.5 followed this order: spring (77.59 µg/m3) > summer (50.76 µg/m3) > winter (49.29 µg/m3) > autumn (42.71 µg/m3). However, the winter season recorded the highest mean values for all gases, CO (946.58 µg/m3), NO2 (9.70 µg/m3), and SO2 (13.07 µg/m3). It was concluded that the southern region of the governorate is more vulnerable to environmental stresses, which can reduce biodiversity and ultimately affect the study area’s climate. In order to manage fragile ecosystems sustainably, this study recommends the creation of efficient land and air management information systems and regulations.
Dose Tapering and Discontinuation of Biologic DMARDs in Axial Spondyloarthritis: A Narrative Review (2023 SPARTAN Annual Meeting Proceedings)
Authors: Chaudhary Haseeb , Bittar Mohamad , Daoud Ansaam , Magrey Marina 
Published: February 2024

Abstract
Purpose of Review
Limited data is available for tapering or discontinuation of biologic therapy in patients with axSpA who are in disease remission. The current review concentrates on published studies regarding dose tapering or withdrawal of biologics in axSpA.

Recent Findings
Recent evidence in light of randomized controlled trials suggests that tapering of b-DMARDs is a feasible strategy to maintain remission or low disease activity in axSpA patients. TNF inhibitors were the studied biologics in most of these trials. The disease flare rates were comparable to those maintained on standard dose in most of these studies, although with variable tapering strategies and follow-up. Additionally, the duration of disease in remission prior to tapering, studied primary outcome, and flare definitions were heterogeneous. Female sex, HLA-B*27 negativity, high physician global score, and high CRP were negative predictors of successful tapering, but not consistently reported in all the trials. Although designed to address efficacy, there were no safety concerns with b-DMARD tapering. Withdrawal or complete discontinuation of biologics met with increased risk of flares compared to standard dosing.

Summary
Tapering of TNF inhibitors may be feasible in certain axSpA patients with an acceptable disease state; however, discontinuation is not currently recommended owing to increased risk of flare. Future studies with axSpA patients with longer remission duration prior to taper and different doses and types of b-DMARDs may provide more guidance.
Fungal Otitis Externa (Otomycosis) Associated with Aspergillus Flavus: A Case Image
Authors: MacDonald William W. , Wakely Paul E. , Kalmar John R. , Argyris Prokopios P. 
Published: February 2024

AbstractA 48-year-old man presented with a chief complaint of intermittent right ear otorrhea of several-month duration, occasional otalgia and progressive unilateral hearing impairment. He also reported frequent episodes of headache and pressure in the sinuses and maxilla. Previous systemic treatment with antibiotics failed to alleviate the symptoms. A head/neck CT showed completely normal mastoid, middle ear and external auditory canal regions without any evidence of opacification or bone erosion. Otoscopic examination of the right ear disclosed aggregates of dried, brown, fibrillar material and debris occluding the external auditory canal and obstructing the otherwise intact tympanic membrane. Dilation of the external auditory canal or thickening of the tympanic membrane were not appreciated. The canal was debrided and the fibrillar material was placed in formalin. Histopathologic examination revealed numerous branching, septated fungal hyphae organized in densely-packed clusters. In other areas, the fungal hyphae abutted or were attached to lamellated collections of orthokeratin. As highlighted by GMS staining, the fungi were morphologically compatible with Aspergillus species. The clinicopathologic findings supported a diagnosis of fungal otitis externa, while the numerous anucleate squamous cells were compatible with colonization of an underlying, probably developing, cholesteatoma. Culture of material isolated from the external auditory canal confirmed the presence of Aspergillus flavus. In this illustrative case, we present the main clinical and microscopic characteristics of Aspergillus-related otomycosis developing in the setting of a tautochronous cholesteatoma.
New technologies in psychological intervention for adolescents with type I diabetes: a systematic review
Authors: Morales Paula , Valero-Moreno Selene , Pérez-Marín Marián 
Published: February 2024

AbstractType I diabetes mellitus (T1D) is a condition typically diagnosed during adolescence. The diagnosis of T1D, combined with the typical changes that occur during this developmental period, can have an impact on the psychopathology of adolescents. The aim of this study is to evaluate the effectiveness of a psychological intervention incorporating new technologies in managing psychopathological aspects among adolescents with T1D. A systematic search was carried out using the PRISMA method in the ProQuest and Web of Science databases, resulting in the screening of 209 studies, of which nine were included. Two evaluators independently and blindly selected and assessed the studies, demonstrating an excellent level of agreement. The age range of participants in the included studies varied from 12 to 21, with the common factor being a T1D diagnosis. The studies examined various variables, such as adherence to treatment, quality of life, and symptoms of depression and anxiety. Many of the studies indicated improvements in these aspects. However, it is crucial to note that the overall quality of the studies was low. Consequently, there is a need for further research on psychological interventions incorporating new technologies, and there is room for improvement in the design quality of such studies. While acknowledging the current limitations, the future of interventions for T1D is intricately linked to advancements in the development and integration of new technologies.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway
Authors: Cao Hongjuan , Zhao Lina , Yuan Yao , Liao Chunyan , Zeng Weidan , Li Aiyue , Huang Quanfeng , Zhao Yueyao , Fan Yubing , Jiang Liu , Song Dandan , Li Sha , Zhang Bei 
Published: February 2024

AbstractThe process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM) has significant antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of ALM on hypertension-induced cardiac hypertrophy, as well as explore its underlying mechanisms. We evaluated the effects of ALM on spontaneously hypertensive rats and rat cardiomyocytes treated with Ang II. We found that ALM was not effective in lowering blood pressure in SHR, but it attenuated hypertension-mediated cardiac fibrosis, oxidative stress, inflammation, and hypertrophy in rats. After that, in cultured H9C2 cells stimulated with Ang II, ALM increased the expression of antioxidant proteins that were decreased in the Ang II group. ALM also alleviated cell hypertrophy and the accumulation of ROS, while LY294002 partially abrogated these effects. Collectively, these results demonstrate that ALM could alleviate oxidative stress in cardiac hypertrophy, potentially through the activation of the PI3K/Akt-mediated Nrf2 signaling pathway.
Graphical Abstract