bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral venous thrombosis: a practical review
Authors: Borhani-Haghighi Afshin , Hooshmandi Etrat 
Published: November 2023

Abstract
The evolution of the Coronavirus Disease-2019 pandemic and its vaccination raised more attention to cerebral venous thrombosis (CVT). Although CVT is less prevalent than arterial stroke, it results in larger years of life lost. CVT is more common in women and young patients. Predisposing factors are categorized as transient factors such as pregnancy, puerperium, oral contraceptive pills, trauma, and dehydration; and permanent factors such as neoplastic, vasculitic, thrombophilic, hematologic conditions, infectious causes such as severe acute respiratory syndrome coronavirus-2 infection and HIV. The most common manifestations are headache, seizures, focal neurologic deficits, altered level of consciousness, and cranial nerve palsies. The most common syndromes are stroke-like, raised-intracranial-pressure (ICP), isolated-headache, and encephalopathy, which may have overlaps. Diagnosis is mostly based on computed tomography, magnetic resonance imaging, and their respective venous sequences, supported by blood results abnormalities such as D-dimer elevation. Treatment includes the prevention of propagation of current thrombus with anticoagulation (heparin, or low molecular weight heparinoids and then warfarin, or direct oral anticoagulants), decreasing ICP (even by decompressive craniotomy), and treatment of specific underlying diseases.
Studying the impact of deuteron non-elastic breakup on 93Zr + d reaction cross sections measured at 28 MeV/nucleon
Authors: Chillery Thomas , Hwang Jongwon , Dozono Masanori , Imai Nobuaki , Michimasa Shin’ichiro , Sumikama Toshiyuki , Chiga Nobuyuki , Ota Shinsuke , Nakayama Shinsuke , Ahn Deuk Soon , Beliuskina Olga , Chikaato Kazuya , Fukuda Naoki , Hayakawa Seiya , Ideguchi Eiji , Iribe Kotaro , Iwamoto Chihiro , Kawase Shoichiro , Kawata Keita , Kitamura Noritaka , Kusaka Kensuke , Masuoka Shoichiro , Miki Hareru , Miyatake Hiroari , Nagae Daisuke , Nakajima Ryo , Nakano Keita , Ohtake Masao , Omika Shunichiro , Ong Hooi Jin , Otsu Hideaki , Sakurai Hiroyoshi , Schrock Philipp , Shimizu Hideki , Shimizu Yohei , Sun Xiaohui , Suzuki Daisuke , Suzuki Hiroshi , Takaki Motonobu , Takechi Maya , Takeda Hiroyuki , Takeuchi Satoshi , Teranishi Takashi , Tsunoda Rieko , Wang He , Watanabe Yukinobu , Watanabe Yutaka X , Wimmer Kathrin , Yako Kentaro , Yamada Hiroki , Yamada Kazunari , Yamaguchi Hidetoshi , Yang Lei , Yanagihara Rikuto , Yanagisawa Yoshiyuki , Yoshida Hiroya , Yoshida Koichi , Shimoura Susumu 
Published: November 2023

Abstract
The deuteron is a loosely bound system that can easily break up into its constituent proton and neutron whilst in the presence of Coulomb and nuclear fields. Previous experimental studies have shown that this breakup process has a significant impact on residual-nucleus production from deuteron bombardment in the high-energy range of 50–210 MeV/nucleon. However, there remains a lack of cross-section data at energies below 50 MeV/nucleon. The current study determined 93Zr + d reaction cross sections under inverse kinematics at approximately 28 MeV/nucleon using the BigRIPS separator, OEDO beamline, and SHARAQ spectrometer. Cross sections from this research were compared with previous measurements and theoretical calculations. The experimental results show a large enhancement of the production cross sections of residual nuclei, especially those produced from a small number of particle emissions, compared to the proton-induced reaction data at similar bombarding energy. The DEURACS calculation, which quantitatively takes deuteron-breakup effects into account, reproduces the data well. As a long-lived fission product, 93Zr remains a challenge for nuclear-waste disposal and treatment. This study’s low-energy data may assist future consideration of nuclear-waste treatment facilities, where 93Zr + d may feasibly transmute the waste into short-lived/stable nuclei.
Neural tracking of social hierarchies in adolescents’ real-world social networks
Authors: Dai Junqiang , Jorgensen Nathan A , Duell Natasha , Capella Jimmy , Maza Maria T , Kwon Seh-Joo , Prinstein Mitchell J , Lindquist Kristen A , Telzer Eva H 
Published: November 2023

Abstract
In the current study, we combined sociometric nominations and neuroimaging techniques to examine adolescents’ neural tracking of peers from their real-world social network that varied in social preferences and popularity. Adolescent participants from an entire school district (N = 873) completed peer sociometric nominations of their grade at school, and a subset of participants (N = 117, Mage = 13.59 years) completed a neuroimaging task in which they viewed peer faces from their social networks. We revealed two neural processes by which adolescents track social preference: (1) the fusiform face area, an important region for early visual perception and social categorization, simultaneously represented both peers high in social preference and low in social preference; (2) the dorsolateral prefrontal cortex (DLPFC), which was differentially engaged in tracking peers high and low in social preference. No regions specifically tracked peers high in popularity and only the inferior parietal lobe, temporoparietal junction, midcingulate cortex and insula were involved in tracking unpopular peers. This is the first study to examine the neural circuits that support adolescents’ perception of peer-based social networks. These findings identify the neural processes that allow youths to spontaneously keep track of peers’ social value within their social network.
Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia
Authors: Tsugawa Sakiko , Honda Shiori , Noda Yoshihiro , Wannan Cassandra , Zalesky Andrew , Tarumi Ryosuke , Iwata Yusuke , Ogyu Kamiyu , Plitman Eric , Ueno Fumihiko , Mimura Masaru , Uchida Hiroyuki , Chakravarty Mallar , Graff-Guerrero Ariel , Nakajima Shinichiro 
Published: November 2023

Abstract

Background and Hypothesis
Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia.

Study Design
We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored.

Study Results
Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group.

Conclusions
These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.
The accumulation–metabolism nexus: internationalization, labour–capital relations, and material flows of French capitalism since the post-war era
Authors: Cahen-Fourot Louison , Magalhães Nelo 
Published: November 2023

Abstract
We investigate the links between accumulation and socio-metabolic regimes by studying French capitalism from socio-economic and material perspectives since 1948. We characterize its social metabolism both in domestic and footprint approaches. The periodization of accumulation regimes in terms of Fordism and finance-led capitalism translates into material terms. The offshore materiality of finance-led capitalism partly substitutes for and partly complements the more domestic materiality inherited from Fordism. The transition phase between the two socio-metabolic regimes clearly corresponds to the emergence of the offshoring–financialization nexus of French capitalism, indicating the shift from Fordism to finance-led capitalism. We highlight strong inter-linkages between accumulation and material dynamics and discuss how materials may be instrumental in shaping accumulation regimes. We therefore introduce the concept of accumulation–metabolism nexus. This work illustrates the relevance of combining institutionalist macroeconomics with Material Flow Analysis.
Christian Nationalism and Opposition to Reallocating Police Funding to Other Social Services
Authors: Liberman Jessica , Lehman Derek , Kawakami Atsuko 
Published: November 2023

Abstract
In the wake of several high-profile cases of police use of excessive force, renewed critiques of policing have emerged from the Defund the Police movement. Yet, the movement has faced fierce opposition from Americans who subscribe to a color-blind logic that racial inequality in policing and society as a whole reflect differences in merit. In assessing Americans’ use of color-blind racism, support for public spending on social services, and support for punitive social control, scholars have recently emphasized the role of Christian nationalist ideology. Building on this recent work, we use data from the 2021 General Social Survey (GSS), a nationally representative survey of Americans, to test the relationship between adherence to Christian nationalist ideology and opposition to reducing funding for police departments and moving those funds to mental health, housing, and other social services. We find that respondents who score higher on an index of Christian nationalism hold greater odds of opposing shifting funding from police departments, independent of other measures of political and religious orientations. We also consider interactions between Christian nationalist ideology, race, and color-blind racial ideology.
HCV E1 influences the fitness landscape of E2 and may enhance escape from E2-specific antibodies
Authors: Zhang Hang , Bull Rowena A , Quadeer Ahmed Abdul , McKay Matthew R 
Published: November 2023

Abstract
The Hepatitis C virus (HCV) envelope glycoprotein E1 forms a non-covalent heterodimer with E2, the main target of neutralizing antibodies. How E1–E2 interactions influence viral fitness and contribute to resistance to E2-specific antibodies remain largely unknown. We investigate this problem using a combination of fitness landscape and evolutionary modeling. Our analysis indicates that E1 and E2 proteins collectively mediate viral fitness and suggests that fitness-compensating E1 mutations may accelerate escape from E2-targeting antibodies. Our analysis also identifies a set of E2-specific human monoclonal antibodies that are predicted to be especially resilient to escape via genetic variation in both E1 and E2, providing directions for robust HCV vaccine development.
Suicide Ideation and Attempt Among People With HIV: A Statewide Population-level Cohort Analysis Between 2005 and 2020
Authors: Mi Tianyue , Zhang Jiajia , Yang Xueying , Chen Shujie , Weissman Sharon , Olatosi Bankole , Li Xiaoming 
Published: November 2023

Background:
Risk factors for suicidality among people with HIV (PWH) may evolve over their disease course, particularly as they develop comorbidities such as mental health disorders over time.

Setting:
This study compared the leading risk factors of suicide ideation/attempt among PWH in South Carolina across different combination antiretroviral therapy (cART) eras.

Methods:
A statewide cohort of PWH who were diagnosed between 2005 and 2016, with a follow-up record until 2020, was involved in the study. A Cox proportional hazards model was used to examine the association of suicide ideation/attempt and predictors, including demographics, HIV-related characteristics, and mental health conditions.

Results:
Among 8567 PWH, the incidence of suicide ideation/attempt increased from 537.7 per 100,000 person-years [95% confidence interval (CI): 460.2 to 615.1] in the early cART cohort (2005–2008) to 782.5 (95% CI: 697.6 to 867.4) in the late cART cohort (2009–2016). Leading risk factors of suicide ideation/attempt changed across the cART cohort. In the early cART cohort, PWH with suicide ideation/attempt were more likely to be White and diagnosed with bipolar disorder (P’s < 0.05). In the late cART cohort, suicide ideation/attempt was positively associated with transmission through injection drug use, anxiety, posttraumatic stress disorder, schizophrenia, and personality disorder (P’s < 0.05).

Conclusions:
Mental health conditions have emerged as more prominent risk factors for suicide ideation/attempt in the late cART cohort. Enhanced access to psychiatric care could facilitate the early identification of mental health conditions, enabling timely counseling or psychosocial interventions that may mitigate mental health issues and, consequently, reduce the likelihood of suicide ideation/attempts among PWH.
Factors Associated With Antiretroviral Adherence Among Youth Living With HIV
Authors: Arnold Elizabeth Mayfield , Kamal Susan , Rotheram-Borus Mary Jane , Bridges S. Kate , Gertsch William , Norwood Peter , Swendeman Dallas ,   the Adolescent Medicine Trials Network (ATN) CARES Team
Published: November 2023

Background:
Youth living with HIV (YLH) have an increased risk for psychosocial stressors that can affect their antiretroviral (ARV) adherence. We examined factors associated with self-reported ARV adherence among YLH ages 12–24 years old.

Setting:
YLH (N = 147) were recruited in Los Angeles, CA, and New Orleans, LA from 2017 to 2020.

Methods:
YLH whose self-reported recent (30 days) ARV adherence was “excellent” or “very good” were compared with nonadherent YLH on sociodemographic, clinical, and psychosocial factors using univariate and multivariate analyses.

Results:
Participants were predominantly male (88%), and 81% identified as gay, bisexual, transgender, queer, or other. The mean duration on ARV was 27 months (range 0–237 months). Most YLH (71.2%) self-reported being adherent, and 79% of those who self-reported adherence were also virally suppressed (<200 copies/mL). Multivariate analysis indicated being adherent was significantly associated with white race [aOR = 8.07, confidence intervals (CI): 1.45 to 74.0], Hispanic/Latinx ethnicity [aOR = 3.57, CI: 1.16 to 12.80], more social support [aOR = 1.11, CI: 1.05 to 1.18], and being on ARV for a shorter duration [aOR = 0.99, CI: 0.97 to 0.99]. Mental health symptoms, substance use, age, and history of homelessness or incarceration were unrelated to adherence.

Conclusions:
Enhancing efforts to provide support for adherence to non-white youth, and those with limited social support and who have been on ARV treatment longer, may help increase viral suppression among YLH.
Text-message based assessment of 90-day modified Rankin Scale after Stroke
Authors: Abbasi Mohammad Hossein , Yuan Kristy , Kasner Scott E. , McPartland Ellen , Owens Karrima C. , Sloane Kelly L. 
Published: November 2023

AbstractBackgroundThe modified Rankin scale (mRS) is commonly used to measure disability after stroke, traditionally assessed through telephone or in-person evaluation. Here, we investigated the validity of mRS assessment through automated text-messaging as an alternative method to traditional assessments.MethodsTwo hundred and fifty patients admitted to 3 hospitals within the University of Pennsylvania Health System with ischemic or hemorrhagic stroke were enrolled. Participants received automated text-messages sent 48 hours prior to their outpatient appointment at about 90-days post-stroke. The mRS scores were assigned based on participant responses to 2-4 text questions eliciting yes/no responses. The mRS was then evaluated in-person or by telephone interview for comparison. Responses were compared with kappa(κ).ResultsOne hundred and forty-two patients (57%) completed the study. Spontaneous response rate to text messages was 46% and up to 72% with an additional direct in-person or phone call reminder. Agreement was substantial (quadratic-weighted κ=0.87) between responses derived from the automated text messaging and traditional interviews. Agreement for distinguishing functional independence (mRS 0-2) from dependence (mRS 3-5) was substantial (unweighted κ=0.79).ConclusionAn automated text messaging system is a feasible and highly reliable for determining mRS and can serve as an alternative to traditional in-person or telephone assessment.
Diagnostic efficacy of hand-held digital refractometer for determining total serum protein in indigenous sheep of Pakistan
Authors: Sharif Madiha , Lashari Mushtaq Hussain , Farooq Umer , Idris Musadiq , Afzal Muhaammad Abrar 
Published: November 2023

AbstractThe study was designed to ascertain the diagnostic efficacy of hand-held digital refractometer in determining total protein. The Sipli sheep (n=141) were grouped as per gender (females=99, males=29) and age (G1=up till 1 year, G2=from 1 to 2 years, G3=above 2 years). The results regarding the overall mean (±SE) values and RIs for the TPs attained through serum chemistry analyzer (TP1) and hand-held digital refractometer (TP2) were non-significantly (P≤0.05) different (59.2±1.6g/L and 59.8±0.5g/L, respectively). However, the RIs were quite different between the two TPs being 45.1-95.7g/L and 57.0-67.0g/L for TP1 and TP2, respectively. Similar results were seen for gender-wise and group-wise results. On the contrary, the results regarding correlation coefficient and logilinear regression showed a negative correlation between the two TPs (r=-0.0244) with an adjusted r-square of 0.059 (5.9% probability). Furthermore, the results for Cronbach alpha and intraclass correlation coefficient between TP1 and TP2 showed that the values for single measure and average values were lower between TP1 and TP2 being - 0.135 and −0.313. Bland and Altman test between TP1 and TP2 also showed a weak level of agreement between the two methods of detecting TP. A proportional bias on the distribution of data around the mean difference line was noticed between TP1 and TP2 (Mean= 0.5; 95% CI= 39.8 to −40.9) with a standard deviation of biasness being 20.58. In a nutshell, the hand-held digital refractometer cannot be used as an on-farm POCT device for determining serum TP in sheep. However, certain other models of refractometers with higher sensitivity and specificity may be utilized in future studies to establish these conclusions for other species of livestock.
PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis
Authors: Straube Johanna , Bukhari Shoiab , Lerrer Shalom , Winchester Robert , Henick Brian , Dragovich Matthew , Mor Adam 
Published: November 2023

AbstractBackgroundPD-1 is an immune checkpoint on T cells and interventions to block this receptor result in T cell activation and enhanced immune response to tumors. Paired to that, and despite a decade of research, approaches to treat autoimmunity with PD-1 agonists still need to be more successful. To resolve this, new methods must be developed to augment PD-1 function beyond engaging the receptor.MethodsWe conducted a flow cytometry analysis of T cells isolated from the peripheral blood and synovial fluid of patients with rheumatoid arthritis. In addition, we performed a genome-wide CRISPR/Cas9 screen to identify genes associated with PD-1 signaling. We further analyzed genes involved in PD-1 signaling using publicly available bulk and single-cell RNA sequencing datasets.ResultsOur screen confirmed known regulators in proximal PD-1 signaling and, importantly, found an additional 1,112 unique genes related to PD-1 ability to inhibit T cell functions. These genes were strongly associated with the response of cancer patients to PD-1 blockades and with high tumor immune dysfunction and exclusion scores, confirming their role downstream of PD-1. Functional annotation revealed that more significant genes uncovered were those associated with known immune regulation processes. Remarkably, these genes were considerably downregulated in T cells isolated from patients with inflammatory arthritis, supporting their overall inhibitory functions. A study of rheumatoid arthritis single-cell RNA sequencing data demonstrated that five genes, KLRG1, CRTAM, SLAMF7, PTPN2, and KLRD1, were downregulated in activated and effector T cells isolated from synovial fluids. Back-gating these genes to canonical cytotoxic T cell signatures revealed PD-1+HLA-DRHIGHKLRGLOWT cells as a novel inflammatory subset of T cells.ConclusionWe concluded that PD-1+HLA-DRHIGHKLRGLOWT cells are a potential target for future PD-1 agonists to treat inflammatory diseases. Our study uncovers new genes associated with PD-1 downstream functions and, therefore, provides a comprehensive resource for additional studies that are much needed to characterize the role of PD-1 in the synovial subset of T cells.
Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response
Authors: Nyirenda James , Hardy Olympia , Da Silva Filho João , Herder Vanessa , Attipa Charalampos , Ndovi Charles , Siwombo Memory , Namalima Takondwa , Suwedi Leticia , Nyasulu Watipenge , Ngulube Thokozile , Nyirenda Deborah , Mvaya Leonard , Phiri Joseph , Chasweka Dennis , Eneya Chisomo , Makwinja Chikondi , Phiri Chisomo , Ziwoya Frank , Tembo Abel , Makwangwala Kingsley , Khoswe Stanley , Banda Peter , Morton Ben , Hilton Orla , Lawrence Sarah , dos Reis Monique Freire , Melo Gisely Cardoso , de Lacerda Marcus Vinicius Guimaraes , Costa Fabio Trindade Maranhão , Monteiro Wuelton Marcelo , de Lima Ferreira Luiz Carlos , Johnson Carla , McGuinness Dagmara , Jambo Kondwani , Haley Michael , Kumwenda Benjamin , Palmarini Massimo , Barnes Kayla G. , Denno Donna M. , Voskuijl Wieger , Kamiza Steve , Couper Kevin , Marti Matthias , Otto Thomas , Moxon Christopher A. 
Published: November 2023

ABSTRACTPostmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTD) including Covid19 but there is almost no data from African settings where HIV, malaria and other environmental exposures may affect disease pathobiology and treatment targets. We used histology and high-dimensional imaging to characterise fatal lung disease in Malawian adults with (n=9) and without (n=7) Covid19, and generated single-cell transcriptomics data from lung, blood and nasal cells. Data integration with other cohorts showed a conserved Covid19 histopathological signature, driven by contrasting immune and inflammatory mechanisms: in the Malawi cohort, by response to interferon-gamma (IFN-γ) in lung-resident alveolar macrophages, in USA, European and Asian cohorts by type I/III interferon responses, particularly in blood-derived monocytes. HIV status had minimal impact on histology or immunopathology. Our study provides data resources and highlights the importance of studying the cellular mechanisms of disease in underrepresented populations, indicating shared and distinct targets for treatment.