bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative network analysis suggests prioritised drugs for atopic dermatitis
Authors: Federico Antonio , Möbus Lena , Al-Abdulraheem Zeyad , Pavel Alisa , Fortino Vittorio , Giudice Giusy del , Alenius Harri , Fyhrquist Nanna , Greco Dario 
Published: November 2023

Abstract

Background
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermis. While several treatments are effective in symptom management, many existing therapies offer only temporary relief and often come with side effects. For this reason, the formulation of an effective therapeutic plan is challenging and there is a need for more effective and targeted treatments that address the root causes of the condition. Here, we hypothesise that modelling the complexity of the molecular buildup of the atopic dermatitis can be a concrete means to drive drug discovery.
Methods
We preprocessed, harmonised and integrated publicly available transcriptomics datasets of lesional and non-lesional skin from AD patients. We inferred co-expression network models of both AD lesional and non-lesional skin and exploited their interactional properties by integrating them with a priori knowledge in order to extrapolate a robust AD disease module. Pharmacophore-based virtual screening was then utilised to build a tailored library of compounds potentially active for AD.
Results
In this study, we identified a core disease module for AD, pinpointing known and unknown molecular determinants underlying the skin lesions. We identified skin- and immune-cell type signatures expressed by the disease module, and characterised the impaired cellular functions underlying the complex phenotype of atopic dermatitis. Therefore, by investigating the connectivity of genes belonging to the AD module, we prioritised novel putative biomarkers of the disease. Finally, we defined a tailored compound library by characterising the therapeutic potential of drugs targeting genes within the disease module to facilitate and tailor future drug discovery efforts towards novel pharmacological strategies for AD.
Conclusions
Overall, our study reveals a core disease module providing unprecedented information about genetic, transcriptional and pharmacological relationships that foster drug discovery in atopic dermatitis.
Water resource utilization efficiency and driving factors in northern Anhui (China) based on the DEA-Malmquist model
Authors: Han Shuxin , Kurniawan Tonni Agustiono , Xu Tiantian , Li Qian , Othman Mohd Hafiz Dzarfan , Fu Dun 
Published: November 2023

Abstract
Based on the DEA-Malmquist method, this study analyzes water resource utilization efficiency in six cities of the northern Anhui region. The input indicators covered per capita water resources, industrial water consumption, agricultural water consumption, domestic water consumption, fixed assets investment, and number of employees. The output indicator was per capita GDP of each city. The findings of the study revealed that only Huaibei achieved efficiency according to the DEA model, while the other cities in the northern Anhui region did not exhibit the same level of efficiency. The overall water resource utilization efficiency in the region was low, with significant variations among the cities (p ≤ 0.05; ANOVA test). The order of water resource utilization efficiency from high to low was Huaibei, Huainan, Bengbu, Bozhou, Suzhou, and Fuyang. An analysis of investment redundancy revealed that a large number of employees and an unreasonable water use structure were key factors that restricted the efficiency of water resource utilization in the region. The overall TFP index of water resource utilization efficiency in the region showed an upward trend, with a value of 1.02. By addressing them, decision-makers can work toward promoting sustainable economic development and effective water resource management in the region.
Experimental Research of Feminitives Comprehension (Data Quantitative Analysis Results)
Authors: Vinogradova M. V. , Kochergina I. V. 
Published: November 2023

The article reveals some results of an experimental research which have been conducted within the psycholinguistic concept of the word meaning. Russian feminitives were chosen as the object of the study due to their nowaday increasing actuality. Indeed, a noticeable burst in female-nominating nouns creation has lately been observed. Thus, functioning of such female nominations meanings seems to be a new and prospective direction of linguistic researches. Having studying identification strategies and mechanisms of the given feminintives meanings as a goal we staged a psycholinguistic experiment. In order to reach the goal the tasks of the cue words frequency and apprehensibility determination and the degree of their foregrounding research were solved. The planning and course of the experiment as well as the results of the first stage of the experimental data processing are described in the present article. The mentioned stage comprised the counting of the responses the experiment participants had given, when asked to identify the cue words as known or unknown and estimate the degree of their meanings transparency. The percentage ratios of the familiar and unfamiliar words are presented in tables. Based upon these figures, several conclusions were arrived at. In particular, only 20 % of the cue words are known to the half of the experiment participants. But for all that almost 90 % of the respondents agreed upon the least comprehensible feminitive as such. Besides, against our expectations, the young people didn’t show a better comprehension and identification of the recent women nomination compared to the nouns which had been picked out from the long-time dictionaries.
Interactive Forms and Methods of Teaching in the Process of Training Personnel for the Restaurant Business (on the Example of the Discipline "Business Culture in the Restaurant Business")
Authors: Solovyanova M. V. , Volobuev V. V. 
Published: November 2023

The modern approach to personnel training for the restaurant business is based, first of all, on the high requirements of employers for staff. This branch of the service sector in comparison with other spheres of activity is characterized by increased dynamics of the emergence of new clientele preferences. This feature leads to the variability of the approach to the organization of educational activities. New training methods are being developed that take into account the features of new technologies introduced by catering organizations and the improvement of customer service standards. Accordingly, the problem of choosing methods and methods of vocational training is becoming increasingly important and relevant. The purpose of mastering the discipline "Business culture in the restaurant business" is the formation of students' competencies that meet the requirements of the Federal State Educational Standard in the direction of training 43.03.03. Hotel business (profile "Restaurant activity"). To achieve this goal, a number of tasks are being solved: to study the features of the discipline "Business culture in the restaurant business"; analyze modern approaches to the development of this discipline; to study the features of the formation of professional skills for the implementation of professional activities; evaluate the effectiveness of using modern digital methods in teaching. In the course of this research, the following methods were used: analysis and generalization of publications of a theoretical and practical nature on the use of interactive technologies in teaching. A selection of publications devoted to improving the process of teaching students was made. Based on the theoretical generalization, a pedagogical experiment was planned and conducted. A comparison of the data obtained based on the results of the conducted pedagogical experiment allows us to assert that the use of interactive technologies in the educational process, namely during practical classes on the academic subject "Business culture in the restaurant business", allows to increase the level of efficiency of mastering educational competencies. The conducted research has shown that the interactive approach can be supplemented with a high degree of efficiency with the use of traditional technologies in teaching students, increasing the level of individualization of vocational training, giving it a creative character.
Echinococcal Cyst Blockade — the Rare Cause of Acute Pancreatitis and Obstructive Jaundice
Authors: Budzinskiy S. A. , Shapovaliants S. G. , Plakhov R. V. , Murashkina M. V. , Vorobyeva E. A. , Berdieva D. R. , Usyaky P. V. , Fedorov E. D. 
Published: November 2023

Aim: demonstrate an algorithm for the diagnosis and treatment of acute pancreatitis and obstructive jaundice caused by obstruction of the terminal part of the common bile duct by daughter echinococcal cyst.Key points. The article presents a clinical case of acute echinococcal obstruction of the terminal part of the common bile duct in a patient with a complicated course of liver echinococcosis. A 33-year-old man was hospitalized with epigastrium and right hypochondrium pains and jaundice. In 2019 the patient underwent the removal of a cyst in the 7th liver segment and cholecystectomy for liver and gallbladder echinococcal lesions. Laboratory research revealed leukocytosis, hyperbilirubinemia and an increase in the transaminases level. Transabdominal ultrasound showed signs of dilatation throughout bile ducts. Duodenoscopy revealed a fixed yellowish-white oval formation with transluent capsule, completely blocking bile and pancreatic juice outflow at the major duodenal papilla. After non-annulation endoscopic papillotomy, migration of the substrate (echinococcal cyst) into the duodenum was noted, active flow of bile and pancreatic secretions was restored. Oral transpapillary cholangioscopy was performed for a detailed bile ducts examination. It revealed no echinococcal cysts, residual parasitic structures or biliary tree lesions. The treatment was completed with pancreatic stenting. After complex treatment in the intensive care and surgery unit with complete condition stabilization, the patient was discharged with recommendations for further treatment in a specialized clinic.Conclusion. Migration of a daughter cyst from the echinococcal liver focus can cause acute blockade of the terminal part of the common bile duct and acute obstructive pancreatitis. The combination of clinical, radiological and endoscopic methods allows to diagnose and eliminate this rare complication of liver echinococcosis with subsequent successful treatment.
Penerapan bimbingan belajar bahasa Inggris bagi siswa sekolah dasar
Authors: Geofaldy Dwi Denaldy  , Syafryadin Syafryadin  
Published: November 2023

Kegiatan bimbingan belajar merupakan proses pendampingan yang bertujuan untuk membantu siswa dalam mencapai potensi belajar mereka yang terbaik. Ini melibatkan berbagai metode dan strategi yang dirancang untuk meningkatkan pemahaman, keterampilan, dan prestasi akademis siswa. Bimbingan belajar bertujuan untuk membantu siswa dalam mengatasi keterbatasan teknologi dan mencapai hasil akademis yang lebih baik. Tujuan bimbingan belajar adalah untuk membantu siswa dalam mengatasi kesulitan belajar, meningkatkan keterampilan studi, mengembangkan kepercayaan diri, dan mencapai hasil akademis yang lebih baik. Metode yang diterapkan sangatlah bervariatif, sehingga anak-anak di Desa Durian Lebar antusias dan mudah memahami makna pembelajaran dengan mudah seperti penjelasan materi (konvensional), latihan soal, penggunaan media belajar (flashcard), simulasi, dan permainan. Hasilnya menunjukkan bahwa bimbingan belajar dapat dimanfaatkan sebagai usaha membimbing anak dengan keterbatasan teknologi sekarang ini di masyarakat Desa Durian Lebar. Sehingga peran perguruan tinggi sebagai institusi intelektual semakin penting perannya dalam proses pengabdian kepada masyarakat secara nyata.
Cytoreductive Surgery and HIPEC in Elderly Patient with Colorectal Cancer and Peritoneal Metastasis
Authors: Gašenko Evita , Pčolkins Andrejs , Bogdanova Inga , Plāte Signe 
Published: November 2023

Background: Colorectal cancer (CRC) patients with peritoneal metastasis have the worst prognosis with a median overall survival of 4.1–8.5 months [1],[2].
Aim: To assess results in the elderly metastatic CRC patient with peritoneal dissemination treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin.
Case Presented: Patient - 70-year-old female with metastatic CRC and peritoneal carcinomatosis. Prior to surgery, received 12 of chemotherapy FOLFOX + bevacizumab. CRS + HIPEC was performed followed by an uneventful recovery. After surgery, she has received chemotherapy with FOLFIRI. The disease progressed 14 months later. The patient has continued therapy with FOLFIRI, unfortunately, the disease has progressed and oral therapy with ftorafur has commenced. Patients’ overall survival so far is 48 months.
Conclusions: Even though we cannot decisively distinguish if results are determined by CRS or additional HIPEC, the presented case shows the importance of a paradigm shift when peritoneal disease in selected patients is viewed as a regional disease rather than diffuse metastatic.
Reducing the calculation time of the sectional convolution operation by taking into account the practical performance of the fast Fourier transform
Authors: Al'tman Evgeniy Anatol'evich , Aleksandrov Aleksandr Vladimirovich 
Published: November 2023

In digital signal processing the question of the speed of the algorithms speed used is becoming more and more relevant. The convolution and correlation operations used are most often based on standard function libraries, which are focused on reducing data processing time by splitting the source data into sections. With small amounts of data, these algorithms work quite efficiently. However, in practice, with a significant increase in the dimension
of the input data, the methods lose quite a lot in the speed of data processing. A method for calculating the convolution of large signals based on the practical performance of the fast Fourier transform is proposed. The optimal size of the section is analyzed, in which the practical performance of existing algorithms remained at a sufficiently high level. Based on the experimental calculations carried out, the optimal dimension of the section used in the convolution calculation formulas was chosen. The proposed method has been tested on published data from various studies. The significant advantages of the proposed method in solving a number of problems are the reduction of the convolution calculation time for long signals by tens of percent and the possibility of fine-tuning the method for specific computing platforms when using preliminary run-time testing on a fast Fourier transform platform of various sizes
Air pollution monitoring with Tradescantia hybrid and optical sensors in Curitiba and Araucária, Brazil
Authors: Rodrigues Leatrice Talita , Mercuri Emílio Graciliano Ferreira , Noe Steffen Manfred 
Published: November 2023

Abstract
Complex mixtures of substances are in the atmosphere and they can cause diseases in humans and biological communities after acute or chronic exposition. This paper focuses on the physical measurement of particulate matter, a proxy for air pollution, and a biological method for mutation assessment due to plants’ exposure to air pollution. The objective of this research was to characterize the air pollution seasonality in municipalities in southern Brazil, and also to understand the relation between air pollution and the biological response of the Tradescantia sp. clone 4430. The optical sensor SDS011 was used for measurements of particulate matter (PM) and the Trad-SHM bioassay was chosen to quantify the mutagenic alterations that occurred in stamen hairs during the study period, with PM data being measured every 5 seconds and the flowers being harvested approximately every two weeks for laboratory analysis. The Pearson test was applied to verify the correlation between PM and mutations in stamen hair as a result of which it was observed that there is a positive correlation between these data, with the highest value found being r = 0.61. Also, the period with the highest occurrence of pink cells was between autumn and spring, the same period in which an unusual increase in PM concentrations was also observed, a period that corresponds to a less favorable dispersion of pollutants in the atmosphere. The use of Tradescantia sp. clone 4430 showed sensitivity to the environments in which it was exposed. Biomonitoring is an important tool for understanding the effects of pollutants on the ecosystem.
REDIZAJN APLIKACIJE ZA SKLOPIVE MOBILNE TELEFONE
Authors: Ilić Vanja , Petrović Saša 
Published: November 2023

Tema ovog rada jeste prilagođavanje postojeće aplikacije "Polovni automobili" za upotrebu na sklopivom telefonu, kao vrsti uređaja koji doživljava veliku ekspanziju. Dizajn za sklopive mobilne telefone predstavlja značajnu stavku prilikom kreiranja aplikacije. Pre svega mora se obratiti pažnja na režime rada ovih telefona. Dva glavna režima jesu otvoren i zatvoren režim. U praksi pak postoji i varijanta poluotvorenog režima gde je iskorišćenje ekrana na maksimalnom nivou, ali su ekrani i dalje podeljeni. Redizajn aplikacije “Polovni automobili” je uključivao prilagođavanje korisničkog interfejsa, iskustva i funkcionalnosti kako bi se iskoristile jedinstvene, inovativne mogućnosti sklopivih mobilnih telefona sa dodatnim ciljem rešavanja problema sa kojima se susreću korisnici aplikacija, otkrivenih analizom aplikacija prisutnih na tržištu.
PERAN BURNOUT SEBAGAI MEDIATOR PADA HUBUNGAN STRES DIGITAL DENGAN INTENSI KELUAR KERJA
Authors: Puspita Debora Dwi , Zamralita Zamralita 
Published: November 2023

This research is to see whether there is a role of digital stress on the turnover intention if mediated by burnout. Turnover intention is the intention of an employee to quit and leave the company, while digital stres is the pressure experienced by employees because of the increased of ICT systems used because of work system’s change from offline to online during the COVID-19 pandemic. This study was conducted with 115 participants using a non-probability sampling method where only 102 samples could be analysed further. Participants of this research is employees that had experience to the work from home working system and work from office with at least one year experience. This measurement of this research are turnover inten by Jung & Yoon (2013), digital stress scale by Fischer et al. (2021) dan burnout assessment tool (BAT) by Schaufeli et al. (2020. Data analysis was carried out using PROCESS and it was found that the correlation between digital stres and work intensity on employees was not significant, either without burnout or mediated by burnout. . Result of this research is digital stress and work intensity on employees were not significant, either without burnout or mediated by burnout. It because the most influence dimension on turnover intention is mental distance.

Penelitian ini untuk melihat apakah terdapat peranan stres digital terhadap intensi keluar kerja jika dimediasi oleh burnout. Intensi keluar kerja adalah niat seorang karyawan untuk berhenti dan keluar dari perusahaan. Stres digital adalah tekanan yang dialami oleh karyawan sebagai akibat dari penggunaan sistem Teknologi Informasi Komunikasi (TIK) yang meningkat yang disebabkan oleh perubahan sistem kerja dari luring (luar jaringan) menjadi daring (dalam jaringan) selama masa pandemi COVID-19. pada dasarnya semua orang akan meninggalkan pekerjaannya dan tidak akan ada satu orang yang akan tinggal bersama dengan organisasi selamanya, terdapat faktor yang mempengaruhi untuk tetap tinggal atau keluar dari perusahaan sehingga sangatlah penting untuk mengetahui cara mengantisipasinya. Penelitian ini dilakukan dengan jumlah sampel 115 partisipan dengan menggunakan metode pengambilan sampel nonprobability sampling dimana hanya 102 sampel yang dapat dianalisa lebih lanjut. Partisipan pada penelitian ini adalah karyawan yang menjalankan sistem kerja dari rumah maupun kerja dari kantor minimal selama satu tahun. Alat ukur yang digunakan pada penelitian ini adalah turnover inten dari Jung & Yoon (2013), digital stress scale dari Fischer et al. (2021) dan burnout assessment tool (BAT) dari Schaufeli et al. (2020). Analisa data dilakukan dengan menggunakan PROCESS dan didapatkan korelasi antara stres digital dan intensi keluar kerja pada karyawan tidak signifikan, baik tanpa dimediasi oleh burnout ataupun dengan mediasi burnout. Hasil penelitian menemukan, bahwa stres digital terhadap intensi keluar kerja pada karyawan tidak signifikan, baik tanpa dimediasi oleh burnout ataupun dengan mediasi burnout.
PERAN LITERASI DIGITAL DAN GROWTH MINDSET PADA UJI MODEL PENERIMAAN APLIKASI PEMBELAJARAN KOLABORATIF
Authors: Suryawidjaja Vincent , Beng Jap Tji , Tiatri Sri 
Published: November 2023

Indonesia akan memasuki masa keemasan pada tahun 2045. Setidaknya terdapat dua hal esensial yang sangat mempengaruhi Indonesia di tahun 2045 yaitu bonus demografi dan kemajuan pesat perkembangan teknologi. Oleh karena itu kualitas tenaga kerja menjadi faktor penting kesuksesan Indonesia di tahun 2045. Untuk mengetahui sejauh mana sebuah teknologi dapat diimplementasikan serta faktor apa saja yang mempengaruhi, diperlukan sebuah model yang komprehensif untuk memotret penerimaan teknologi tersebut sehingga proses transformasi digital dapat dipercepat. Salah satu model penerimaan teknologi yang sudah ada yaitu The Unified Theory of Acceptance and Use of Technology (UTAUT). Tujuan dalam penelitian ini adalah untuk mengembangkan model penerimaan Teknologi Digital dalam Pembelajaran Kolaboratif melalui Pendekatan UTAUT pada Siswa Sekolah Dasar dan Menengah di Indonesia dengan mempertimbangkan variabel Literasi Digital dan Growth Mindset. Teknik analisis yang digunakan dalam penelitian ini adalah uji model menggunakan SEM-PLS. Partisipan penelitian ini berjumlah 298 siswa di jenjang SD hingga SMA pada sekolah-sekolah di daerah Jakarta, Tangerang, dan Bekasi. Hasil Penelitian ini menunjukkan signifikansi peran Perfomance Expectancy, Effort Expectancy dan Social Influence terhadap minat siswa menggunakan aplikasi pembelajaran kolaboratif. Hasil penelitian ini juga menunjukkan bahwa Literasi Digital secara signifikan berkontribusi pada Effort Expectancy siswa sedangkan Growth Mindset berkontribusi signifikan pada Performance Expectancy. Hasil penelitian ini merekomendasikan untuk dapat menyediakan ekosistem pembelajaran kolaboratif yang mengoptimalisasi penggunaan teknologi demi menghasilkan generasi-generasi unggul untuk menyambut Indonesia Emas 2045.