bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Dukungan Bidan dan Keluarga dengan Kecemasan Ibu Hamil Trimester Ke III dalam Menghadapi Persalinan di Klinik Uswah Medika Tunjung Teja
Authors: Umairo Gusrida , Anggraini Yeni 
Published: October 2023

ABSTRACT Kecemasan yang terjadi selama kehamilan telah dilaporkan dapat meningkatkan kemungkinan janin yang dilahirkan memiliki berat badan lahir rendah (BBLR), meningkatkan resiko terhambatnya perkembangan janin (intra uteine growth retardation (IUGR), dan kelahiran premature. Beberapa penelitian menyatakan bahwa untuk mengurangi kecemasan dibutuhkan peran bidan dan keluarga selama kehamilan, persalinan, dan masa menyusui. Tujuan penelitian ini adalah untuk menganalisis hubungan antara dukungan keluarga dan dukungan bidan dengan penurunan kecemasan pada ibu hamil trimester III di klinik Uswah Medika Tahun 2022. Design cross sectional. Penelitian ini dilakukan di Klinik Uswah Medika Tunjung Teja, Serang-Banten pada November hingga Desember 2022. Sampel penelitian ini sejumlah 42 Orang. Instrumen pengukuran untuk variable kecemasan menggunakan skala HARS (Hamilton anxiety rating scale). Analisis bivariate menggunakan menggunakan Spearman rank. Hasil analisis didapatkan nilai p-value 0,000 dengan koefisien (r) 0.57 menunjukan bahwa terdapat hubungan yang kuat antara dukungan bidan dalam menurunkan kecemasan. Nilai p-value = 0,001 dengan koefisien (r) 0.48 menunjukan bahwa terdapat hubungan yang cukup kuat antara dukungan keluarga dalam menurunkan kecemasan. Keywords: Dukungan Bidan, Dukungan Keluarga, Kecemasan
БОЇ ЗА ПУКТИ ПРОПУСКУ НА УКРАЇНО-РОСІЙСЬКОМУ ДЕРЖАВНОМУ КОРДОНІ ПІД ЧАС АНТИТЕРОРИСТИЧНОЇ ОПЕРАЦІЇ (ЧЕРВЕНЬ – СЕРПЕНЬ 2014 РОКУ)
Authors: Ананьїн Олег 
Published: October 2023

Розглянуто хід та результати бойових дій підрозділів Державної прикордонної служби України та незаконних збройних формувань «ДНР/ЛНР» за контроль над пунктами пропуску на ділянках українсько-російського державного кордону у межах територій Донецької та Луганської областей.
У червні 2014 року місцеві органи влади фактично втратили контроль над суспільно-політичною ситуацією у прикордонних районах Луганської та Донецької областей. З кожним днем збільшувалася кількість випадків проведення біля прикордонних підрозділів різних несанкціонованих мітингів за участю місцевих мешканців. Їхніми вимогами до прикордонників були здати зброю та перейти на бік, так званого, «народу Донбасу».
У загрозливому становищі на державному кордоні опинилися пункти пропуску. Більшість з них були розташовані на значному віддалені від відділів прикордонної служби, яким підпорядковувалися. Блок-пости бойовиків «ДНР/ЛНР» на автошляхах ускладнювали доставку до пунктів пропуску змін прикордонних нарядів. У разі нападу бойовиків прикордонні резерви не мали можливості вчасно надати необхідну допомогу. Незважаючи на складну обстановку, прикордонники продовжували нести службу на визначених ділянках. У такий ситуації Уряд України змушений був припинити здійснення прикордонного контролю та закрити 8 пунктів пропуску на українсько-російському державному кордоні у межах Донецької та Луганської областей.
Найбільші за тривалістю часу та значенням для Антитерористичної операції у період червень – серпень 2014 року стали бойові дії за пункти пропуску у районах населених пунктів Довжанське, Ізварине, Маринівка та Червонопартизанськ. Контроль над захопленими пунктами пропуску через державний кордон надав бойовикам можливості вільно отримувати з території РФ зброю, боєприпаси, людські та матеріально-технічні ресурси. Що стало однією з багатьох причин, які унеможливили для української влади успішне завершення активної фази АТО в літку 2014 року.
ПІХОТНА АРТИЛЕРІЯ ДРУГОЇ СВІТОВОЇ ВІЙНИ: НІМЕЦЬКИЙ ПІДХІД
Authors: Харук Андрій 
Published: October 2023

Німецький підхід до організації піхотної артилерії в роки Другої світової війни відзначався продуманістю і системністю. Він передбачав як технічні заходи (створення артилерійських систем відповідного призначення), так і організаційно-штатні (введення підрозділів піхотної артилерії в структуру полків, а в окремих випадках – батальйонів). До початку 1930-х рр. в Німеччині були створені два основних взірці артсистем цього класу – легка піхотна гармата leIG 18 і важка sIG 33. Після початку Другої світової війни головним напрямком їх удосконалення стало підвищення мобільності, зокрема, створення самохідних артилерійських установок з гарматами sIG 33. Основною організаційною формою піхотної артилерії була полкова рота піхотних гармат. Однак в деяких випадках легкі піхотні гармати вводились в стркутуру батальйонів. Це обумовлювалось специфікою піхоти рігських стрілецьких і танкових дивізій.
Evaluation and Mapping the Atmospheric Air Quality of Coastal Area in Bangladesh Using Remote Sensing and GIS Techniques
Authors: Hasan Md Mahmudul , Ahmed Asib 
Published: October 2023

The coastal region of Bangladesh is increasingly suffering from air pollution in recent years. This study represents an analysis of the mean atmospheric column nitrogen dioxide (NO2), Sulphur di oxide (SO2), Ozone (O3), and carbon monoxide (CO) over the coastal area of Bangladesh during 2018-2022 period. Measurements of nitrogen dioxide (NO2), Sulphur di oxide (SO2), Ozone (O3) and carbon monoxide (CO) were obtained from recently launched Sentinel-5 Precursor spacecraft using Tropospheric Monitoring Instrument (Sentinel-5P TROPOMI). The aim of this study is to evaluate and visualize coastal air quality using relatively high-resolution data. PM2.5 was analyzed for the period of 1998-2019 year and the data was collected from the SEDAC website. The NO2, SO2, O3, PM2.5, and CO satellite data were then used in Google Earth Engine (GEE) and ArcGIS 10.7 software for further analysis and retrieval of the atmospheric data. The findings showed significantly high values for Khulna, Jashore, Satkhira, and Narail districts. From the NO2 observation, high values were identified in Chandpur, Shariatpur, and Lakshmipur with a highest average value of 74.2 μmol/m2. It was found that the SO2 and O3 were present significantly high over the Khulna, Bagerhat, Satkhira, and Narail districts. Particulate Matter PM2.5 exceeded BNAAQS value in every year since 1998 all over the coastal Districtswith an average value of 56 μg/m3. Years 2020 and 2021 were found much clean air than the other study years might be due to the Covid-19 Lockdown all over the country. From the trend analysis, it was found that most of the air pollutants showed an increasing trend. The interior coast was found more polluted than the exposed coast. The overall results of this study confirmed the capability of Sentinel-5P TROPOMI data to be used in monitoring the air quality over coastal areas of Bangladesh. This study highlights the widespread problem of air pollution in the coastal districts of Bangladesh and emphasizes the need for immediate action to tackle this issue.
The Dhaka University Journal of Earth and Environmental Sciences, Vol. 11(2), 2022, P 53-65
ANÁLISE DA RESPONSABILIDADE CIVIL OBJETIVA NO CONTEXTO JURISPRUDENCIAL DO TRIBUNAL SUPERIOR DO TRABALHO
Authors: Alberti Vantoir , Klaus Júnior Cláudio Antônio 
Published: October 2023

A aplicação da teoria da responsabilidade civil objetiva no direito trabalhista passou a ser debatida com maior intensidade a partir da vigência do Código Civil de 2002, em razão do disposto no em seu artigo 927, parágrafo único. A partir do julgamento do Recurso Extraordinário n. 828.040 pelo Supremo Tribunal Federal restou pacificado entendimento de que é aplicável a responsabilidade objetiva nas hipóteses previstas em lei ou às atividades que expõem o trabalhador de forma habitual a risco especial com potencialidade maior que os demais membros da coletividade de sofrer acidente de trabalho ou adquirirem doença ocupacional. Dado este cenário, o objetivo do presente trabalho é identificar atividades que, atualmente, são consideradas de risco pela jurisprudência do Tribunal Superior do Trabalho. E, como resultado, pode-se afirmar que as atividades de manejo de gado, de transporte coletivo, repetitivas em estabelecimento bancário e frigorífico, transporte aéreo, no trânsito, na construção civil, em barragens e em fundição de ferro e aço são consideradas de risco pelo Tribunal Superior do Trabalho.
PALAVRAS CHAVE: Responsabilidade civil patronal. Responsabilidade objetiva. Aplicabilidade.

ABSTRACT
The application of the objective civil liability theory in labor law began to be debated with greater intensity after the Civil Code of 2002 came into force, due to the provisions of article 927, sole paragraph. From the judgment of Extraordinary Appeal n. 828,040 by the Federal Supreme Court, the understanding that strict liability is applicable in the cases provided for by law or to activities that regularly expose the worker to a special risk with a greater potential than the other members of the community to suffer an accident at work or acquire a disease occupational. Given this scenario, the objective of this work is to identify activities that are currently considered risky by the jurisprudence of the Superior Labor Court. And, as a result, it can be said that the activities of handling livestock, public transport, repetitive activities in banking and cold storage, air transport, traffic, civil construction, dams and iron and steel foundries are considered of risk by the Superior Labor Court.
Keywords: Employer civil liability. Strict liability. Applicability.
Association of novel lipid indicators with the risk of stroke among participants in Central China: a population-based prospective study
Authors: Huang Qin , Yin Li , Liu Zeyu , Wei Minping , Feng Jie , Huang Qing , Liu Yunhai , Liu Zunjing , Xia Jian 
Published: October 2023

BackgroundSeveral easily and inexpensively measured indicators of visceral adiposity dysfunction are currently available, but it remains unclear whether they are correlated with stroke risk in the community-dwelling population. We aimed to examine the longitudinal association of the triglyceridemic-waist phenotypes, the triglyceride glucose (TyG) index, as well as TyG-related indicators with stroke risk.MethodsIn this study, we conducted a prospective cohort study in Hunan, a region located in Central China, where the prevalence of stroke is relatively high. We included a total of 20185 subjects aged ≥40 years between November 2017 and December 2018. Triglyceride glucose-body mass index (TyG-BMI) and triglyceride glucose-waist circumference (TyG-WC) were calculated as multiplying TyG index by BMI and WC, respectively. Triglyceride waist phenotypes were categorized into four phenotypes: HTGW (elevated triglyceride and enlarged WC), NTNW (normal triglyceride and normal WC); HTNW (high triglyceride and normal WC), and NTGW (normal triglyceride and enlarged WC). We constructed a multivariable Cox regression model to assess the association between these novel lipid indicators and the risk of stroke. Subgroup analysis was conducted to test the robustness of our research findings. ROC curve was used for assessing the predictive ability of different stroke risk indices.ResultsAfter 2 years of follow- up, 135 participants experienced new stroke events. After adjusting for potential confounders, we found that participants with HTGW had higher likelihood of stroke (HR: 1.96, 95% CI: 1.21 to 3.16). However, we did not find significant associations for HTNW (HR: 1.42, 95% CI: 0.91 to 2.21) and NTGW (HR: 1.09, 95% CI 0.67 to 1.78). when compared to participants in the first TyG quartile, those in the fourth TyG quartile were associated with a 2.06-fold (95% CI: 1.22, 3.50) risk of stroke. Each 1-SD increase in TyG, TyG-BMI, and TyG-WC was associated with a higher risk of stroke, with adjusted HRs of 1.34 (95% CI: 1.11 to 1.61), 1.35 (95% CI: 1.14 to 1.59), and 1.23 (95% CI: 1.04 to 1.46), respectively. In subgroup analyses, those positive relationships appeared to be stronger among male participants with lower levels of physical activity and smoking.ConclusionHTGW, along with higher levels of TyG and TyG-related indicators, were found to be associated with an elevated risk of stroke. HTGW and these novel lipid indicators might be reliable indicators to identify populations at elevated risk of stroke.
An optimized procedure for preparation of conditioned medium from Wharton’s jelly mesenchymal stromal cells isolated from umbilical cord
Authors: Acuto Santina , Lo Iacono Melania , Baiamonte Elena , Lo Re Rosa , Maggio Aurelio , Cavalieri Vincenzo 
Published: October 2023

Cell-free therapy based on conditioned medium derived from mesenchymal stromal cells (MSCs) has gained attention in the field of protective and regenerative medicine. However, the exact composition and properties of MSC-derived conditioned media can vary greatly depending on multiple parameters, which hamper standardization. In this study, we have optimized a procedure for preparation of conditioned medium starting from efficient isolation, propagation and characterization of MSCs from human umbilical cord, using a culture medium supplemented with human platelet lysate as an alternative source to fetal bovine serum. Our procedure successfully maximizes the yield of viable MSCs that maintain canonical key features. Importantly, under these conditions, the compositional profile and biological effects elicited by the conditioned medium preparations derived from these MSC populations do not depend on donor individuality. Moreover, approximately 120 L of conditioned medium could be obtained from a single umbilical cord, which provides a suitable framework to produce industrial amounts of toxic-free conditioned medium with predictable composition.
Reduced structural connectivity in non-motor networks in children born preterm and the influence of early postnatal human cytomegalovirus infection
Authors: Pretzel Pablo , Wilke Marko , Tournier J-Donald , Goelz Rangmar , Lidzba Karen , Hauser Till-Karsten , Groeschel Samuel 
Published: October 2023

IntroductionPreterm birth is increasingly recognized to cause lifelong functional deficits, which often show no correlate in conventional MRI. In addition, early postnatal infection with human cytomegalovirus (hCMV) is being discussed as a possible cause for further impairments. In the present work, we used fixel-based analysis of diffusion-weighted MRI to assess long-term white matter alterations associated with preterm birth and/or early postnatal hCMV infection.Materials and methods36 former preterms (PT, median age 14.8 years, median gestational age 28 weeks) and 18 healthy term-born controls (HC, median age 11.1 years) underwent high angular resolution DWI scans (1.5 T, b = 2 000 s/mm2, 60 directions) as well as clinical assessment. All subjects showed normal conventional MRI and normal motor function. Early postnatal hCMV infection status (CMV+ and CMV−) had been determined from repeated screening, ruling out congenital infections. Whole-brain analysis was performed, yielding fixel-wise metrics for fiber density (FD), fiber cross-section (FC), and fiber density and cross-section (FDC). Group differences were identified in a whole-brain analysis, followed by an analysis of tract-averaged metrics within a priori selected tracts associated with cognitive function. Both analyses were repeated while differentiating for postnatal hCMV infection status.ResultsPT showed significant reductions of fixel metrics bilaterally in the cingulum, the genu corporis callosum and forceps minor, the capsula externa, and cerebellar and pontine structures. After including intracranial volume as a covariate, reductions remained significant in the cingulum. The tract-specific investigation revealed further reductions bilaterally in the superior longitudinal fasciculus and the uncinate fasciculus. When differentiating for hCMV infection status, no significant differences were found between CMV+ and CMV−. However, comparing CMV+ against HC, fixel metric reductions were of higher magnitude and of larger spatial extent than in CMV− against HC.ConclusionPreterm birth can lead to long-lasting alterations of WM micro- and macrostructure, not visible on conventional MRI. Alterations are located predominantly in WM structures associated with cognitive function, likely underlying the cognitive deficits observed in our cohort. These observed structural alterations were more pronounced in preterms who suffered from early postnatal hCMV infection, in line with previous studies suggesting an additive effect.
Words hurt: common and distinct neural substrates underlying nociceptive and semantic pain
Authors: Borelli Eleonora , Benuzzi Francesca , Ballotta Daniela , Bandieri Elena , Luppi Mario , Cacciari Cristina , Porro Carlo Adolfo , Lui Fausta 
Published: October 2023

IntroductionRecent studies have shown that processing semantic pain, such as words associated with physical pain, modulates pain perception and enhances activity in regions of the pain matrix. A direct comparison between activations due to noxious stimulation and processing of words conveying physical pain may clarify whether and to what extent the neural substrates of nociceptive pain are shared by semantic pain. Pain is triggered also by experiences of social exclusion, rejection or loss of significant others (the so-called social pain), therefore words expressing social pain may modulate pain perception similarly to what happens with words associated with physical pain. This event-related fMRI study aims to compare the brain activity related to perceiving nociceptive pain and that emerging from processing semantic pain, i.e., words related to either physical or social pain, in order to identify common and distinct neural substrates.MethodsThirty-four healthy women underwent two fMRI sessions each. In the Semantic session, participants were presented with positive words, negative pain-unrelated words, physical pain-related words, and social pain-related words. In the Nociceptive session, participants received cutaneous mechanical stimulations that could be either painful or not. During both sessions, participants were asked to rate the unpleasantness of each stimulus. Linguistic stimuli were also rated in terms of valence, arousal, pain relatedness, and pain intensity, immediately after the Semantic session.ResultsIn the Nociceptive session, the ‘nociceptive stimuli’ vs. ‘non-nociceptive stimuli’ contrast revealed extensive activations in SI, SII, insula, cingulate cortex, thalamus, and dorsolateral prefrontal cortex. In the Semantic session, words associated with social pain, compared to negative pain-unrelated words, showed increased activity in most of the same areas, whereas words associated with physical pain, compared to negative pain-unrelated words, only activated the left supramarginal gyrus and partly the postcentral gyrus.DiscussionOur results confirm that semantic pain partly shares the neural substrates of nociceptive pain. Specifically, social pain-related words activate a wide network of regions, mostly overlapping with those pertaining to the affective-motivational aspects of nociception, whereas physical pain-related words overlap with a small cluster including regions related to the sensory-discriminative aspects of nociception. However, most regions of overlap are differentially activated in different conditions.
Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome
Authors: Nakakubo Sachiko , Hiramatsu Yasuyoshi , Goto Takeru , Kimura Syuhei , Narugami Masashi , Nakajima Midori , Ueda Yuki , Shiraishi Hideaki , Manabe Atsushi , Sharmin Dishary , Cook James M. , Egawa Kiyoshi 
Published: October 2023

Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na channel. Pre-synaptic inhibitory dysfunction is regarded as the pathophysiological mechanism, but an effective strategy for ameliorating seizures and behavioral problems is still under development. Here, we evaluated the effects of KRM-II-81, a newly developed positive allosteric modulator for α 2/3 subunit containing GABAA receptors (α2/3-GABAAR) in a mice model of DS both in vivo and at the neuronal level.Methods: We used knock-in mice carrying a heterozygous, clinically relevant SCN1A mutation (background strain: C57BL/6 J) as a model of the DS (Scn1aWT/A1783V mice), knock-in mouse strain carrying a heterozygous, clinically relevant SCN1A mutation (A1783V). Seizure threshold and locomotor activity was evaluated by using the hyperthermia-induced seizure paradigm and open filed test, respectively. Anxiety-like behavior was assessed by avoidance of the center region in locomotor activity. We estimated a sedative effect by the total distance traveled in locomotor activity and grip strength. Inhibitory post synaptic currents (IPSCs) were recorded from a hippocampal CA1 pyramidal neuron in an acutely prepared brain slice.Results: KRM-II-81 significantly increased the seizure threshold of Scn1aWT/A1783V mice in a dose-dependent manner. A low dose of KRM-II-81 specifically improved anxiety-like behavior of Scn1aWT/A1783V mice. A sedative effect was induced by relatively high dose of KRM-II-81 in Scn1aWT/A1783V mice, the dose of which was not sedative for WT mice. KRM-II-81 potentiated IPSCs by increasing its decay time kinetics. This effect was more prominent in Scn1aWT/A1783V mice.Discussion: Higher activation of α2/3-GABAAR by KRM-II-81 suggests a compensatory modification of post synaptic inhibitory function against presynaptic inhibitory dysfunction in Scn1aWT/A1783V. The increased sensitivity for KRM-II-81 may be relevant to the distinct dose-dependent effect in each paradigm of Scn1aWT/A1783V mice.Conclusion: Selective activation for α2/3-GABAAR by KRM-II-81 could be potential therapeutic strategy for treating seizures and behavioral problems in DS.
Effect of depression on phase coherence between respiratory sinus arrhythmia and respiration during sleep in patients with obstructive sleep apnea
Authors: Alzaabi Yahya , Khandoker Ahsan H. 
Published: October 2023

Introduction: A high prevalence of major depressive disorder (MDD) among Obstructive Sleep Apnea (OSA) patients has been observed in both community and clinical populations. Due to the overlapping symptoms between both disorders, depression is usually misdiagnosed when correlated with OSA. Phase coherence between respiratory sinus arrhythmia (RSA) and respiration (λ RSA-RESP) has been proposed as an alternative measure for assessing vagal activity. Therefore, this study aims to investigate if there is any difference in λ RSA-RESP in OSA patients with and without MDD.Methods: Electrocardiograms (ECG) and breathing signals using overnight polysomnography were collected from 40 OSA subjects with MDD (OSAD+), 40 OSA subjects without MDD (OSAD-), and 38 control subjects (Controls) without MDD and OSA. The interbeat intervals (RRI) and respiratory movement were extracted from 5-min segments of ECG signals with a single apneic event during non-rapid eye movement (NREM) [353 segments] and rapid eye movement (REM) sleep stages [298 segments]. RR intervals (RRI) and respiration were resampled at 10 Hz, and the band passed filtered (0.10–0.4 Hz) before the Hilbert transform was used to extract instantaneous phases of the RSA and respiration. Subsequently, the λ RSA-RESP between RSA and Respiration and Heart Rate Variability (HRV) features were computed.Results: Our results showed that λ RSA-RESP was significantly increased in the OSAD+ group compared to OSAD- group during NREM and REM sleep. This increase was accompanied by a decrease in the low frequency (LF) component of HRV.Discussion: We report that the phase synchronization index between RSA and respiratory movement could provide a useful measure for evaluating depression in OSA patients. Our findings suggest that depression has lowered sympathetic activity when accompanied by OSA, allowing for stronger synchronization between RSA and respiration.