bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Perubahan Garis Pantai Pesisir Domas, Serang, Banten dari Tahun 1988 hingga 2023 Berdasarkan Data Citra Satelit Landsat
Authors: Amanu Rendy Syahril , Syah Muhammad Jouhar , Oktabrian Krisna Dwi , Nugraheni Imma Redha 
Published: February 2025

: Perubahan garis pantai merupakan salah satu fenomena yang terjadi di daerah pesisir. Di Indonesia perubahan garis pantai dapat disebabkan oleh berbagai faktor, baik alami maupun antropogenik. Penelitian ini berfokus pada analisis perubahan garis pantai di sekitar Pesisir Domas, Serang, Banten dari tahun 1988 hingga 2023 menggunakan data citra satelit Landsat. Tujuan utama dari penelitian ini adalah untuk memetakan dan mengukur perubahan garis pantai yang terjadi dari tahun 1988 hingga 2023. Metode yang digunakan dalam penelitian ini adalah Normalized Difference Water Index (NDWI) untuk interpretasi garis pantai serta analisis perubahan luasan garis pantai. Selain itu digunakan Digital Shoreline Analysis System (DSAS) untuk analisis jarak perubahan garis pantai serta identifikasi perubahan garis pantai. Hasil penelitian menunjukkan perubahan garis pantai yang terjadi selama periode penelitian cukup signifikan dengan total luasan daerah berkurang 388 hektar atau rata-rata berkurang 11,08 hektar per tahun. Analisis DSAS berdasarkan nilai Net Shoreline Movement (NSM) menunjukkan bahwa perubahan jarak garis pantai rata-rata adalah -368,76 meter, dengan perubahan terbesar adalah 1.032,6 meter. Nilai End Point Rate (EPR) menunjukkan laju rata-rata perubahan per tahun sebesar -10,69 meter, dengan nilai EPR terbesar adalah -29,5 meter. Penelitian ini menunjukkan bahwa terjadi kemunduran garis pantai yang disebabkan abrasi.
Pemanfaatan ekstrak daun Bruguiera gymnorrhiza sebagai sabun padat dan bioaktivitasnya terhadap bakteri Escherichia coli
Authors: Wittriansyah Khoeruddin , Kristiningsih Ari , Purwanti Theresia Evila 
Published: February 2025

Mangrove diketahui memiliki potensi dan manfaat yang luas bagi masyarakat Pesisir. Upaya pengembangan produk mangrove adalah menjadikannya sebagai produk sabun. Penelitian ini bertujuan untuk membuat sabun padat dengan bahan ekstrak daun B. gymnorrhiza. Sabun B. Gymnorrhiza kemudian diuji aktivitas antibakteri terhadap E.Coli. Variabel penambahan ekstrak daun B. Gymnorrhiza sebanyak P1 (7,5ml), P2 (15ml), P3 (20ml) dan K(0ml). Analisa Mutu Sabun B. Gymnorrhiza yang dihasilkan, meliputi pengukuran pH, stabilitas busa, dan uji hedonik (tekstur, aroma, kenampakan dan warna). Hasil penelitian menunjukkan bahwa zona hambat terhadap E.Coli terbesar terdapat pada sabun P2 pada kosentrasi 100 μl yaitu sebesar (18,5 mm). pH sabun yang sesuai dengan standar SNI 3532:2016 adalah P2 dan P3. Uji stabilitas busa menunjukkan hasil untuk K (44%), P1 (50%), P2 (40%) dan P3 (44%). Bedasarkan Uji stabilitas busa tersebut, sabun padat B. Gymnorrhiza belum dikategorikan baik. Uji Hedonik menunjukkan panelis lebih menyukai sabun tanpa penambahan ekstrak daun B. Gymnorrhiza (K) untuk parameter penampakan, aroma dan warna, sedangkan untuk parameter tekstur yang paling disukai adalah P1. Bedasarkan hasil penelitian ekstrak daun B. Gymnorrhiza dapat dimanfaatkan sebagai sabun padat dan memiliki bioaktivitas untuk menghambat bakteri E.Coli.
An observational comparative study on the immediate, deferred, and no use of antiepileptics in the management of seizure
Authors: Shrestha Himangi , Krishnan Athira , Ramaiah Balakeshwa 
Published: February 2025

Background: The rationale for starting AEDs in patients with seizure and early epilepsy is still unclear. The decision to start and stop the drugs in patients with single seizures remains controversial. This study aims to compare the efficacy, safety, and short-term outcome of the immediate, deferred, and no use of AEDs in patients presenting with seizure.
Methods This observational study, included 87 patients with either gender or age group with first or multiple seizures to investigate immediate, deferred, or no AED use. Detailed demographics, history, and diagnostic test reports were recorded. Drug use patterns and outcomes of seizure recurrence and safety were evaluated.
Results: Out of 87 patients (56 male, 31 female), there were 26 paediatrics, 47 adults, and 15 elderly. Immediate AED treatment was given to 75%, 16% deferred, and 9% received no/SOS AED. Levetiracetam was commonly prescribed (78% in ED, 86% in wards, 63% at discharge). For immediate AEDs: 49% had good seizure control, 25% had recurrence, and 9% had breakthrough seizures. Deferred AEDs showed 36% good control/recurrence and 7% breakthrough. Without AEDs: 63% had good control and 25% had recurrence. AEs were higher in the immediate AED group (42%) vs. deferred (15%).
Conclusions: The study indicates that immediate use of antiepileptic drugs (AEDs) reduces short-term seizure recurrence but may increase adverse effects. In cases of reversible causes, it may be best to forgo AEDs. Decisions regarding AED therapy should be tailored to the patient's preferences and risk considerations.
Transferência de segredos industriais por meio de smart contracts considerando-se o Paradoxo da Informação de Arrow
Authors: Schüler Erik , O Felipe Octaviano Delgado Busnello , Anderson Ricardo Yanzer Cabral  
Published: February 2025

No estado da arte existem sistemas para transferência de ativos intangíveis protegidos por Propriedade Intelectual, consolidados por monopólios jurídicos, seja por sistemas atributivos (como para patentes e desenhos industriais) ou automaticamente protegidos (como direitos autorais e conexos). Alguns desses sistemas, ou seus respectivos métodos, são descritos na literatura científica. Deste conjunto, alguns métodos utilizam a tecnologia de blockchain, e um conjunto menor (inteiramente contido no anterior) também utiliza a tecnologia de smart contracts, embora sejam ferramentas independentes entre si. Apesar de os segredos industriais também consistirem em monopólios, as soluções informatizadas ou em ambientes criptográficos aplicadas para outros tipos de bens protegidos por outras formas de propriedade intelectual não podem ser transpostas a esses ativos, em razão de sua natureza sui generis, carente de monopólio que independa de sua não revelação. A necessidade de manutenção do segredo decorre do Paradoxo da Informação de Arrow, fenômeno pelo qual a revelação do segredo implica sua transferência. Esse fenômeno prejudica a potencial transferência de segredos industriais e inviabiliza a adoção dos sistemas existentes aplicáveis aos demais tipos de ativos intangíveis. A investigação utilizou a metodologia mista. Este trabalho apresenta um método para transferência de segredos industriais utilizando-se smart contracts instanciados em blockchain para solução de dois dos três elementos componentes do Paradoxo, especificamente a confiabilidade e a capacidade, pressupondo o terceiro, a relevância.
Endothelial function/damage markers and NGAL – intraoperative assessment in blood specimens obtained from different sampling sites during open repair of abdominal aortic aneurysm
Authors: Kokot Michał , Biolik Grzegorz , Kokot Anna , Kędzierski Leszek , Fojt Tadeusz , Ziaja Damian , Ziaja Krzysztof , Duława Jan 
Published: February 2025

WPROWADZENIE:Celem pracy było zbadanie dynamiki zmian stężenia lipokainy związanej z żelatynazą neutrofilów (<i>neutrophil gelatinase-associated lipocalin</i> – NGAL), która jest wskaźnikiem ostrego uszkodzenia nerek, oraz wskaźników czynności/uszkodzenia śródbłonka: selektyny P, cząsteczki adhezji międzykomórkowej 1 (<i>intercellular adhesion molecule 1</i> – ICAM-1), cząstki adhezyjnej śródbłonka naczyniowego 1 (<i>vascular cell adhesion molecule 1</i> – VCAM-1) i czynnika von Willebranda (<i>von Willebrand factor</i> – vWf) w próbkach krwi pobieranych z różnych obszarów naczyniowych podczas elektywnej operacji naprawczej tętniaka aorty brzusznej (<i>abdominal aortic aneurysm</i> – AAA) metodą otwartą.MATERIAŁ I METODY:Badanie objęło grupę 33 chorych zakwalifikowanych do planowego zabiegu metodą otwartą (<i>open repair</i> – ORe). Wszystkie wymienione parametry oznaczono w próbkach krwi pobranych: 1) przed zabiegiem z żyły łokciowej oraz w trakcie zabiegu; 2) z żyły nerkowej przed założeniem zacisku aorty; 3) z żyły nerkowej bezpośrednio przed zwolnieniem zacisku aorty; 4) z żyły łokciowej bezpośrednio przed zwolnieniem zacisku aorty; 5) z żyły głównej dolnej bezpośrednio przed zwolnieniem zacisku aorty; 6) z żyły nerkowej w 5 minucie po zwolnieniu zacisku aorty; 7) z żyły łokciowej w 5 minucie po zwolnieniu zacisku aorty.WYNIKI:Stwierdzono zmniejszenie stężenia selektyny P, ICAM-1 i VCAM-1 w próbkach pobranych z żyły łokciowej bezpośrednio przed zdjęciem zacisku aorty oraz 5 minut po zdjęciu zacisku aorty w porównaniu z wartościami przed zabiegiem. Ponadto obserwowano nagłe zmiany stężenia NGAL, vWf i VCAM-1 podczas zabiegu.WNIOSKI:Uzyskane wyniki wydają się przemawiać za rozwojem stanu zapalnego już w trakcie zabiegu operacyjnego AAA metodą otwartą.
Investigating lysosomal dysfunction in Fabry disease using induced pluripotent stem cell-derived podocytes
Authors: Ryan Caitlin R. , Wise Andrea F. , Tindoy Elisha , Bruell Shoni , Fuller Maria , Nicholls Kathleen M. , Ricardo Sharon D. 
Published: February 2025

Aims: This study used induced pluripotent stem cell-derived podocytes from a Fabry disease (FD) patient carrying the p.Met284Thr pathogenic variant as an in vitro model to investigate lysosomal abnormalities driving cell pathology. Proteomic analysis was used to assess changes in lysosomal protein abundance in FD podocytes compared to controls. Additionally, temporal changes in lysosome number in FD podocytes were analyzed using automated live-cell imaging.
Methods: Label-free mass spectrometry proteomics was performed on FD podocytes at day 10 of differentiation compared to controls. For live-cell imaging, cultured podocytes were transfected with CellLight Lysosomes-GFP and Plasma Membrane-CFP, and then visualized and quantified on days 10 and 20 post-differentiation using a Perkin Elmer Phenix High Content Screening Microscope.
Results: Proteomic analysis showed dysregulation of glycosphingolipid metabolism proteins, including decreased galactosidase alpha (GLA; P < 0.01) and increased galactosylceramidase and glucosylceramidase (P < 0.01) in FD podocytes. Lysosomal proteins were enriched, with a significant increase in cathepsin B (P < 0.001) and a decrease in lipase A (P < 0.01). Furthermore, the dysregulation of proteins involved in cell cycle regulation and growth signaling pathways, such as polo-like kinase 1 (PLK1; P < 0.0001) and proto-oncogene tyrosine-protein kinase Src (SRC; P < 0.01), suggested broader impacts on cellular processes. Temporal live-cell imaging revealed a significant increase in lysosome number in day 20 FD podocytes compared to day 10 FD podocytes and controls (P < 0.01).
Conclusions: These findings collectively suggest that FD podocytes undergo progressive lysosomal impairment, which may contribute to cellular dysfunction and disease progression. These proof-of-concept findings lay a foundation for future research on targeted FD therapies using high-throughput screening and advanced analytical techniques.
Role of Fragility of the Glass Formers in the Yielding Transition under Oscillatory Shear
Authors: Karmakar Smarajit , Chatterjee Roni , Adhikari Monoj 
Published: February 2025

Abstract

Metallic glasses are widely used amorphous materials known for their exceptional mechanical properties, such as high yield strength and large yield strain. Understanding the microscopic mechanisms behind their failure, particularly the yielding transition, remains an active
area of research. Previous studies have shown that yielding behavior depends on the initial age of the sample. Through extensive computer simulations, we demonstrate that this age dependence varies across different materials and is influenced by the specific characteristics of the initial glass former, particularly its fragility. Both strong and fragile glass formers exhibit similar behavior in poorly annealed conditions, but the yield point increases significantly with annealing for fragile glasses while remaining relatively constant for strong glasses. We rationalize these findings by introducing a new elastoplastic model, which qualitatively reproduces the simulation results and offers valuable insights into the physics of the yielding transition under oscillatory shear deformation.
Both small heat shock protein and J-Domain protein direct defense against Areca palm velarivirus 1 (APV1) by degrading coat protein via autophagy pathway
Authors: Huang Xi , Cao Xianmei , Lu Jie , Xing Zengyu , Zhai Jingling , Wang Hongxing , Zhao Ruibai 
Published: February 2025

Abstract

Both autophagy and heat shock proteins (HSPs) play dual roles in promoting or inhibiting viral infections. However, the coordination between autophagy and HSPs in the defense against viral infections remains underexplored, and the underlying mechanisms are still poorly understood. This study first revealed an interaction between a cytosolic small heat shock protein (AcsHSP) and a type II J-domain protein (AcDNAJB13) of areca palm with the coat protein (CP) of Areca Palm Velarivirus 1 (APV1) and the interaction is independent of the HSP70 chaperones. The closest homologs in Nicotiana benthamiana (NbsHSP and NbDNAJB13) also interacted with CP. Both AcsHSP and AcDNAJB13 were localized in the cytoplasm and nucleus, and co-expression with CP altered AcsHSP intracellular localization. APV1 infection or transient CP expression induced the expression of AcsHSP and AcDNAJB13, which, in turn, inhibited CP accumulation. Virus-induced gene silencing (VIGS) of NbsHSP and NbDNAJB13 significantly increased the accumulation of transiently expressed CP-GFP. CP degradation occurred via an autophagic pathway. Both AcsHSP and AcDNAJB13 interacting with AcATG8f1, and these interactions were required for CP degradation. Furthermore, silencing endogenous NbsHSP and NbDNAJB13 enhanced APV1 replication, while overexpression of AcsHSP reduced APV1 accumulation. Our findings demonstrate that AcsHSP and AcDNAJB13 function as selective cargo receptors for CP degradation via autophagy pathway, thereby limiting APV1 infection and offering new insights into the roles of heat shock protein families.
Inhibition of polymeric densification at platinum/ionomer interface via enlarging tetrafluoroethylene spacing in perfluorinated sulfonic-acid ionomer
Authors: Jung Chi-Young , Choi Wonyoung , Choi Hyunguk , Park Youngje , Choi Seowon , Cho Hyeon E , Lee Namjin , Yoon Younggi , Yi Sungchul , Ko Min Jae 
Published: February 2025

Abstract

Polymer electrolyte fuel cells hold great potential for powering heavy-duty vehicles (HDVs) run by clean hydrogen, but a major challenge lies in the ionomer poisoning of scarce platinum (Pt) catalysts, which hinders the Pt utilization and cell efficiency. Here, we report a simple yet effective approach to mitigate polymeric densification at the Pt/ionomer interface, via enlarging tetrafluoroethylene (TFE) spacing between neighboring side chains. Ionomers with weaker confinement to Pt, arising from strengthened hydrophobic interactions, suppress the specific adsorption and lead to less-densified ionomer morphology. Despite having a lower ion-exchange capacity, they exhibited high accessibilities (over 80%) and a significant reduction of 22–8% in sulfonate coverage, hence resulting in two-fold improvements in activity and local transport towards the oxygen reduction reaction. This strategy offers a key solution to unlock the full potential of Pt, offering seamless integration into current manufacturing processes, thus accelerating the sustainability and scalability of fuel cell technology.
Pathways to global hydrogen production within planetary boundaries
Authors: Hauschild Michael , Lejeune Michaël , Kara Sami , Shahrabifarahani Sareh , Daiyan Rahman 
Published: February 2025

Abstract

Hydrogen is regarded as a key lever for decarbonising hard-to-electrify sectors and industries. Future projections suggest that a significant increase in global hydrogen production is required to limit global warming to 1.5°C. However, the planetary footprint of global hydrogen production is not well understood, particularly when considering potential interactions between Earth's biophysical systems. This study quantifies planetary footprint using a bottom-up hydrogen production system considering potential planetary boundary interactions. Here, we show that from 2025 to 2050, even under the most sustainable scenarios, global hydrogen production is unsustainable with multiple boundary transgressions. As opposed to current trends, we find that biomass-based production has the potential to amplify boundary transgression levels. We also find that an increased electrolytic hydrogen production capacity with concurrent carbon removal will be required to alleviate the planetary footprint of global hydrogen production. Our general analysis confirms the need to re-evaluate the “green hydrogen” concept, which, besides the sole focus on climate change, largely overlooks critical interactions between Earth's biophysical systems. Therefore, achieving absolute sustainability for global hydrogen production will require reconsidering environmentally viable production pathways.
Coherent Manipulation of Second-Harmonic Generation via Terahertz-Field Mediated Phonon-Polariton in Zinc Oxide
Authors: Tian Ye , Fang Yifei , Hao Jiajing , Sang Jianhua , Gao Jixing , Song Liwei , Li Ruxin 
Published: February 2025

Abstract

The coherent control of phonon polaritons (PhPs) in holds transformative potential for nonlinear photonics. We demonstrate terahertz-driven excitation of low-frequency PhPs in zinc oxide (ZnO) crystals, with their nonlinear dynamics resolved via time-resolved second harmonic generation (SHG) spectroscopy. By achieving phase matching via nine sequential reflections within a millimeter-scale crystal, we observe sustained SHG oscillations with 3–4 THz modulation frequencies, achieving optimal extinction ratios of ~18 dB that persist for 90 picoseconds—a temporal span directly governed by polariton propagation dynamics. This work establishes a dual-functionality platform enabling spectral-temporal resolved mapping of quasiparticle interaction dynamics while simultaneously advancing polariton-engineered nonlinear optical modulators through symmetry-broken frequency conversion architectures.
DECODE: Deep learning-based common deconvolution framework for various omics data
Authors: Wang Yadong , Zhao Tianyi , Liu Renjie , Sun Yuzhi , Zhang Liyuan , Luo Ruibang , Cheng Liang 
Published: February 2025

Abstract

Deconvolution algorithm enables estimation of cell type abundances from tissue-level data, providing a crucial way for exploring plentiful cohort data at the cellular level. However, most deconvolution algorithms are specifically designed for single-omics data, thereby limiting their generalizability and scalability for multiomics data from different cohorts. A deconvolution algorithm applicable to various omics data can use cell abundance as a bridge to improve the comparability of different cohorts. Here, we developed DECODE, a universal deconvolution framework of both cell type and cell state designed for transcriptomics, proteomics and metabolomics data, which seamlessly integrates diverse multiomics tissue datasets in cellular level. DECODE fills the gap in metabolomics deconvolution and significantly outperformed state-of-the-art methods on different omics data across donors, disease conditions, healthy states, and measurement platforms. In addition, DECODE exhibits high robustness in scenarios that are closer to real applications, that it can accurately deconvolve known cell types even when the reference single-cell data incomplete all cell types of target tissue. DECODE will serve as a powerful tool for the fully extending multiomics cohort data into cellular level.
Types of Subducted Material Controlling Tethyan Porphyry Copper Mineralization
Authors: Yang Zhiming , Li Hua-Wei , Lu Yongjun , Hou Zeng-Qian 
Published: February 2025

Abstract

The Tethyan orogenic belt underwent prolonged tectonic evolution and hosts numerous world-class porphyry copper deposits. Notably, most porphyry deposits are associated with Cenozoic continental collision, while fewer are formed during Mesozoic subduction. Here we integrate detrital zircon oxybarometry with geochemical data, stratigraphy, sea-level and temperature fluctuations, and major geological events. Our results reveal a stark redox transition–from anoxic during Mesozoic subduction to oxidized during Cenozoic collision. We propose that subduction of organic-rich, reduced sediments in the Mesozoic suppressed the oxidation state of arc magmas, locking chalcophile elements in the lower crust and inhibiting the formation of subduction-related porphyry Cu deposits. In contrast, the subduction of more oxidized sediments during the Cenozoic elevated oxygen fugacity, releasing stored metals and promoting extensive formation of porphyry Cu deposits during continental collision. These findings underscore the critical role of sediment redox state and subduction history in governing porphyry mineralization along the Tethyan belt.
Dominant substitutions underlying the antigenic evolution of H5 influenza virus
Authors: Li Qianqian , Wu Aiping , Wang Youchun , Zhang Mengyi , Qin Luyao , Li Zichen , Chen Jiamin , Tong Jincheng , Ding Xiao , Li Huan , Ma Yun , Liu Jingze , He Qiuju , Bi Rong , Huang Weijin , Bian Cheng 
Published: February 2025

Abstract

Highly pathogenic avian influenza (HPAI) H5 viruses have recently been documented in mammals including humans, posing a major threat to global public health. To prevent a potential H5 pandemic, it is critical to elucidate the antigenic evolutionary pattern and identify key drivers underlying its evolution. In this study, we constructed a comprehensive antigenic map of H5 influenza viruses spanning their evolutionary history for the first time, revealing three distinct antigenic clusters (AC1, AC2, and AC3) with no cross-neutralization. In contrast to its sequential genetic evolution, AC3 lies between AC1 and AC2 in antigenic space. This divergence stems from two distinct mutation patterns at six key amino acid positions: (1) persistent mutations at positions 88 (N > R > S), 199 (D > N > S), and 205 (K > N > D), and (2) reversible mutations at positions 131 (Q > L > Q), 139 (S > P > S), and 289 (N > H > N). Moreover, single mutations at positions 205 and 289 can lead to significant immune escape. The risk clade of current interest, 2.3.4.4b belongs to AC2 and remains sensitive to current AC2-targeted vaccine strains. Additionally, clades 2.3.2.1c of AC1 and 2.3.4.4h of AC3 are also prevalent and capable of human infection, necessitating continuous surveillance of their epidemiological dynamics. These findings not only reveal the antigenic evolution mechanism of H5 influenza unseen in other influenza viruses, but also provide important guidance for vaccine strain selection and broad-spectrum vaccine development.