bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Komunikasi dan Kerjasama Tim Terhadap Produktivitas Kerja (Studi pada Puskesmas Karangpucung 2 Kabupaten Cilacap)
Authors: Makmur Hidayat Adi , Budianto Apri , Herman Ferey 
Published: February 2024

Penelitian ini dilatarbelakangi oleh adanya beberapa masalah yang berhasil diidentifikasi sebagai berikut: Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap dilihat dari aspek efektivitas masih belum efektif. Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap dilihat dari aspek ketepatan waktu pegawai dalam menyelesaikan pekerjaan masih kurang tepat. Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap dilihat dari aspek capaian hasil kerja pegawai yang sesuai dengan target yang telah ditentukan masih kurang. Produktivitas kerja pegawai Puskesmas Karangpucung II Kabupaten Cilacap dilihat dari efesiensi biaya yang di gunakan masih belum optimal. Komunikasi antara pegawai dengan pegawai masih belum optimal. Komunikasi antara pegawai dengan atasan dapat di katakan masih belum optimal. Masih ada beberapa pegawai yang sulit untuk di ajak kerjasama dalam menyelesaikan pekerjaan. Kerjasama yang terdiri dari banyak orang menuntut adanya kesamaan ide dan gagasan yang sulit untuk di wujudkan Dengan demikian maka tujuan penelitian ini adalah untuk mengetahui dan mendeskripsikan pengaruh komunikasi terhadap produktivits kerja pada Puskesmas Karangpucung 2 Kabupaten Cilacap. Untuk mengetahui dan mendeskripsikan pengaruh kerjasama tim terhadap produktivits kerja pada Puskesmas Karangpucung 2 Kabupaten Cilacap?. Untuk mengetahui dan mendeskripsikan pengaruh komunikasi dan kerjasama tim terhadap produktivits kerja pada Puskesmas Karangpucung 2 Kabupaten Cilacap.Metode yang digunakan adalah deskriptif survey. Hasil penelitian menunjukkan bahwa Komunikasi cenderung baik dan produktivitas kerja pegawai cenderung baik, sehingga komunikasi berpengaruh positif dan signifikan terhadap produktivitas kerja pegawai. Artinya, semakin baik komunikasi, maka akan semakin baik produktivitas kerja pegawai. Kerjasama tim cenderung baik dan produktivitas kerja pegawai cenderung baik, sehingga Kerjasama tim berpengaruh positif dan signifikan terhadap produktivitas kerja pegawai. Artinya, semakin baik Kerjasama tim, maka akan semakin baik produktivitas kerja pegawai. Komunikasi dan kerjasama tim secara serentak berpengaruh terhadap produktivitas kerja pegawai . Pengaruh komunikasi dan kerjasama terhadap produktivitas kerja pegawai termasuk kategori tinggi.
Pengaruh Motivasi, Komitmen Pegawai Dan Kompetensi Terhadap Kinerja Pegawai (Studi pada Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak Kabupaten Ciamis)
Authors: Herawati Sri , Budianto Apri , Herman Ferey 
Published: February 2024

Penelitian ini melakukan sebuah riset penelitian dalam menilai pengaruh motivasi, komitmen dan kompetensi terhadap kinerja pegawai. Rumusan masalah yang diajukan dalam penelitian ini yaitu sebagai berikut: 1) Bagaimana pengaruh Motivasi tehadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis?; 2) Bagaimana pengaruh komitmen pegawai tehadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis; 3) Bagaimana pengaruh kompetensi terhadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis. 4) Bagaimana pengaruh Motivasi, komitmen pegawai dan kompetensi terhadap kinerja pegawai pada DP2KBP3A Kabupaten Ciamis? Metode penelitian yang digunakan adalah metode kuantitatif deskriptif dengan metode penyebaran kusioner atau angket. Teknik pengumpulan data dalam penelitian ini adalah studi pustaka dan studi lapangan. Sedangkan teknis analisis data yang digunakan penulis dalam penelitian ini yaitu dengan penyebaran kusioner Dari penelitian bahwa dapat diperoleh: 1) Hasil dari penelitian di DP2KBP3A Kabupaten Ciamis berpengaruh positif terhadap kinerja petugas dan berpengaruh signifikan, artinya apabila motivasi, komitmen dan kompetensi yang sangat tinggi maka akan berpengaruh terhadap kinerja petugas. Jadi motivasi, komitmen dan kompetensi adalah factor utama dalam meningkatkan kinerja petugas pada Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan dan Perlindungan Anak Kabupaten Ciamis akan meningkat pula.
Aleteo auricular: caso clínico
Authors: Banegas Santos Evelyn Johanna , Mendoza Rivas Rodrigo José , Yunga Corte Aida Marlene 
Published: February 2024

Introducción. El aleteo auricular es una enfermedad que no pone en peligro la vida y puede ser muy sintomática debido a las altas frecuencias ventriculares que normalmente ocurren. El diagnóstico es fácil porque solo se requiere un ECG de 12 derivaciones. En pacientes que no pueden revertir o prevenir el aleteo, se puede intentar con éxito la resección del nódulo aurícula ventricular y la implantación de un marcapasos permanente. Las técnicas de ablación por radiofrecuencia ahora son muy exitosas para revertir el aleteo auricular y prevenir su inducibilidad y recurrencia. Objetivo: Determinar el manejo de la patología aleteo auricular para presentar aspectos nuevos o instructivos de la enfermedad. Metodología: estudio de caso clínico de tipo descriptiva, retrospectivo. La técnica que se utilizó para la recolección de la información del caso fue mediante la revisión de historia clínica y para la descripción de la patología será mediante la recopilación de artículos extraídos de bases de datos reconocidas como: Scopus, PorQuest, Pubmed, web of science, lilacs. Como criterio de inclusión: artículos publicados en los últimos 5 años, en español e inglés. El caso cuenta con el consentimiento informado del paciente para dar cumplimiento a lo establecido por Bioética. Resultados: Se identificaron las principales causas, síntomas y signos, el diagnóstico, tratamiento y prevención del aleteo auricular, como personal de salud es de vital importancia adquirir nuevos conocimientos sobre esta patología que afecta con más frecuencia a adultos. Conclusiones: El mayor riesgo de desarrollar aleteo auricular son los hombres, los ancianos y las personas con insuficiencia cardíaca preexistente o enfermedad pulmonar obstructiva crónica es por ello que nuestro estudio fue aplicable el tratamiento con antiarrítmicos, además de anticoagulantes. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos.
Estenosis Mitral: Caso Clínico
Authors: Cárdenas Álvarez Adriana Marisela , Salas Contreras Francy Hollminn , Moyano Brito Edisson Gustavo 
Published: February 2024

Introducción. La estenosis y la insuficiencia pulmonar, son patologías que ocasionan alteraciones en el flujo de sangre dentro de las cavidades derechas del corazón. Se presentan mayoritariamente como defectos congénitos, pero en una gran cantidad de pacientes no son diagnosticadas sino hasta llegar a la edad adulta; debido a la poca sintomatología que usualmente presentan y debido al gran periodo de latencia que tienen de forma asintomática. Objetivo. Determinar las principales manifestaciones clínicas y los métodos diagnósticos de las patologías de la válvula pulmonar a través de un caso clínico, con el fin de ayudar a facilitar sus diagnósticos tempranos. Metodología. Estudio de caso clínico de tipo descriptivo, retrospectivo. La recolección de la información del caso se realizará mediante la revisión de la historia clínica. La expectativa del siguiente trabajo de investigación es identificar las principales causas, síntomas y signos, el diagnóstico, tratamiento y prevención de la estenosis e insuficiencia pulmonar. Resultados. Presentamos el caso de una femenina de 34 años edad con antecedente de valvulopatía pulmonar en la infancia y 24 horas de evolución de disnea más dolor retroesternal. Se realizan los exámenes complementarios y se diagnostica una estenosis con insuficiencia pulmonar. Se Realiza una cirugía de reemplazo valvular y es dada de alta con buen pronóstico. Conclusión. La principal manifestación de las enfermedades de la válvula pulmonar son manifestaciones características de insuficiencia cardiaca derecha y retención de líquidos. El principal estudio diagnóstico de las enfermedades de la válvula pulmonar es la ecocardiografía más estudio Doppler. El tratamiento de elección en estenosis e insuficiencia pulmonar cuando los síntomas son graves es el reemplazo valvular. Las enfermedades valvulares pulmonares cuando son diagnosticadas correctamente e intervenidas a tiempo, suelen tener una remisión muy buena y el pronóstico es favorable. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos.
Computational identification of antibody-binding epitopes from mimotope datasets
Authors: Li Rang , Wilderotter Sabrina , Stoddard Madison , Van Egeren Debra , Chakravarty Arijit , Joseph-McCarthy Diane 
Published: February 2024

Introduction: A fundamental challenge in computational vaccinology is that most B-cell epitopes are conformational and therefore hard to predict from sequence alone. Another significant challenge is that a great deal of the amino acid sequence of a viral surface protein might not in fact be antigenic. Thus, identifying the regions of a protein that are most promising for vaccine design based on the degree of surface exposure may not lead to a clinically relevant immune response.Methods: Linear peptides selected by phage display experiments that have high affinity to the monoclonal antibody of interest (“mimotopes”) usually have similar physicochemical properties to the antigen epitope corresponding to that antibody. The sequences of these linear peptides can be used to find possible epitopes on the surface of the antigen structure or a homology model of the antigen in the absence of an antigen-antibody complex structure.Results and Discussion: Herein we describe two novel methods for mapping mimotopes to epitopes. The first is a novel algorithm named MimoTree that allows for gaps in the mimotopes and epitopes on the antigen. More specifically, a mimotope may have a gap that does not match to the epitope to allow it to adopt a conformation relevant for binding to an antibody, and residues may similarly be discontinuous in conformational epitopes. MimoTree is a fully automated epitope detection algorithm suitable for the identification of conformational as well as linear epitopes. The second is an ensemble approach, which combines the prediction results from MimoTree and two existing methods.
Automatic segmentation of skeletal muscles from MR images using modified U-Net and a novel data augmentation approach
Authors: Lin Zhicheng , Henson William H. , Dowling Lisa , Walsh Jennifer , Dall’Ara Enrico , Guo Lingzhong 
Published: February 2024

Rapid and accurate muscle segmentation is essential for the diagnosis and monitoring of many musculoskeletal diseases. As gold standard, manual annotation suffers from intensive labor and high inter-operator reproducibility errors. In this study, deep learning (DL) based automatic muscle segmentation from MR scans is investigated for post-menopausal women, who normally experience a decline in muscle volume. The performance of four Deep Learning (DL) models was evaluated: U-Net and UNet++ and two modified U-Net networks, which combined feature fusion and attention mechanisms (Feature-Fusion-UNet, FFU, and Attention-Feature-Fusion-UNet, AFFU). The models were tested for automatic segmentation of 16-lower limb muscles from MRI scans of two cohorts of post-menopausal women (11 subjects in PMW-1, 8 subjects in PMW-2; from two different studies so considered independent datasets) and 10 obese post-menopausal women (PMW-OB). Furthermore, a novel data augmentation approach is proposed to enlarge the training dataset. The results were assessed and compared by using the Dice similarity coefficient (DSC), relative volume error (RVE), and Hausdorff distance (HD). The best performance among all four DL models was achieved by AFFU (PMW-1: DSC 0.828 ± 0.079, 1-RVE 0.859 ± 0.122, HD 29.9 mm ± 26.5 mm; PMW-2: DSC 0.833 ± 0.065, 1-RVE 0.873 ± 0.105, HD 25.9 mm ± 27.9 mm; PMW-OB: DSC 0.862 ± 0.048, 1-RVE 0.919 ± 0.076, HD 34.8 mm ± 46.8 mm). Furthermore, the augmentation of data significantly improved the DSC scores of U-Net and AFFU for all 16 tested muscles (between 0.23% and 2.17% (DSC), 1.6%–1.93% (1-RVE), and 9.6%–19.8% (HD) improvement). These findings highlight the feasibility of utilizing DL models for automatic segmentation of muscles in post-menopausal women and indicate that the proposed augmentation method can enhance the performance of models trained on small datasets.
Systemic-to-pulmonary collateral flow associations with antegrade pulmonary flow in single ventricle patients: insights from cardiac magnetic resonance imaging
Authors: Yanovskiy Anna , Martelius Laura , Nyman Nicolina , Vepsäläinen Teemu , Mattila Ilkka , Rahkonen Otto , Ojala Tiina 
Published: February 2024

PurposeIn the palliated single ventricle anomalies, a considerable amount of the aortic flow may be absorbed by the systemic-pulmonary collateral flow (SPCF), which can be noninvasively assessed by cardiac magnetic resonance (CMR). The aims of this study were to (1) identify factors associated with SCPF in pediatric single ventricle patients, and (2) establish a cutoff values indicating an association between SCPF and a reduction in antegrade pulmonary flow.MethodsA retrospective single-tertiary-center cohort study included 158 consecutive CMR studies of patients with a single ventricle. In the uni- and multivariable analysis, SPCF was presented as a percentage of the total pulmonary venous flow (SPCF%PV). The minimal clinically important difference in QP/QS ratios was estimated as ≥0.50, and an optimal cutoff value was defined using the receiver operating characteristic (ROC) curve.ResultsSPCF%PV was significantly smaller in the post-total cavopulmonary connection (TCPC) group than in the pre-TCPC patients (p &lt; 0.001). The patient's higher age and a higher antegrade pulmonary flow were associated with a lower SPCF%PV. A negative weak association was observed between the SPCF%PV and systemic saturation (r = −0.39, p &lt; 0.001). SPCF%PV did not associate with ventricular volumes nor ejection fraction. The SPCF%PV was significantly smaller in patients that were palliated primarily with a pulmonary artery banding compared to those palliated with a BT-shunt (p = 0.002) or RV-PA- shunt (p = 0.044). In the ROC analysis, for pre-TCPC patient's, a cutoff of SPCF%PV 42% yielded a sensitivity of 100% and specificity of 80% for significantly reduced antegrade pulmonary flow (AUC 0.97). In the post-TCPC group, the optimal SPCF%PV cutoff was 34% (sensitivity 100%, specificity 98%, AUC 0.99).ConclusionSPCF results in a considerable left-to-right shunt, which subsequently diminishes spontaneously after TCPC. Our findings indicated that for pre-TCPC patients, an SPCF%PV threshold of 42% (sensitivity 100%, specificity 80%), and for the post-TCPC group, a threshold of 34% (sensitivity 100%, specificity 98%) were effective in identifying reduced antegrade pulmonary flow.
Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus: dual evidence from NHANES database and Mendelian randomization analysis
Authors: Yan Zhaoqi , Xu Yifeng , Li Keke , Liu Liangji 
Published: February 2024

BackgroundLow levels of high-density lipoprotein cholesterol (HDL-C) are commonly seen in patients with type 2 diabetes mellitus (T2DM). However, it is unclear whether there is an independent or causal link between HDL-C levels and T2DM. This study aims to address this gap by using the The National Health and Nutrition Examination Survey (NHANES) database and Mendelian randomization (MR) analysis.Materials and methodsData from the NHANES survey (2007-2018) with 9,420 participants were analyzed using specialized software. Logistic regression models and restricted cubic splines (RCS) were used to assess the relationship between HDL-C and T2DM incidence, while considering covariates. Genetic variants associated with HDL-C and T2DM were obtained from genome-wide association studies (GWAS), and Mendelian randomization (MR) was used to evaluate the causal relationship between HDL-C and T2DM. Various tests were conducted to assess pleiotropy and outliers.ResultsIn the NHANES study, all groups, except the lowest quartile (Q1: 0.28-1.09 mmol/L], showed a significant association between HDL-C levels and reduced T2DM risk (all P &lt; 0.001). After adjusting for covariates, the Q2 [odds ratio (OR) = 0.67, 95% confidence interval (CI): (0.57, 0.79)], Q3 [OR = 0.51, 95% CI: (0.40, 0.65)], and Q4 [OR = 0.29, 95% CI: (0.23, 0.36)] groups exhibited average reductions in T2DM risk of 23%, 49%, and 71%, respectively. In the sensitivity analysis incorporating other lipid levels, the Q4 group still demonstrates a 57% reduction in the risk of T2DM. The impact of HDL-C levels on T2DM varied with age (P for interaction = 0.006). RCS analysis showed a nonlinear decreasing trend in T2DM risk with increasing HDL-C levels (P = 0.003). In the MR analysis, HDL-C levels were also associated with reduced T2DM risk (OR = 0.69, 95% CI = 0.52-0.82; P = 1.41 × 10-13), and there was no evidence of pleiotropy or outliers.ConclusionThis study provides evidence supporting a causal relationship between higher HDL-C levels and reduced T2DM risk. Further research is needed to explore interventions targeting HDL-C levels for reducing T2DM risk.
Exploring genetic variation and phylogenetic patterns of Tropilaelaps mercedesae (Mesostigmata: Laelapidae) populations in Asia
Authors: Mohamadzade Namin Saeed , Joharchi Omid , Aryal Sunil , Thapa Ratna , Kwon Sun-Ho , Kakhramanov Boymakhmat A. , Jung Chuleui 
Published: February 2024

IntroductionThe mites belonging to the genus Tropilaelaps are ectoparasites of honey bees, primarily infesting the larval and pupal stages. Originating from subtropical regions, these mites can cause brood malformation, bee mortality, and subsequent decline or absconding of colonies.Material and methodsDuring field surveys conducted in Nepal, South Korea, and Uzbekistan to investigate honey bee pests, several populations of T. mercedesae were collected. This is the first record of T. mercedesae from Uzbekistan. The morphological characteristics of the collected populations were analyzed, and their phylogenetic relationship with other Asian populations was examined.Results and discussionThe molecular analysis of cytochrome oxidase I gene revealed high similarity between Uzbekistan and Pakistan populations, signaling the potential invasion of subtropical honey bee parasites into the Central Asian beekeeping sectors. Phylogenetic analysis indicated the presence of four distinct lineages within the mainland-Indonesian populations of T. mercedesae. Notably, an evolutionary divergence was observed between the haplotypes from Sri Lanka and the Philippines compared to the remaining mainland Asian and Indonesian haplotypes, suggesting the possible existence of subspecies or separate species in these isolated locations. To gain a deeper understanding of this phenomenon, it is essential to continue monitoring the spread of this significant honey bee pest and conduct comprehensive morphological and molecular analyses of samples collected from these specific localities.
Potential causal associations of PM2.5 and osteoporosis: a two-sample mendelian randomization study
Authors: Zhang Yi , Yu Jinsheng , Pei Hang , Zhao Xinzheng , Wang Chao , Wang Guanyin , Shen Zan , Hua Jiang , He Bangjian 
Published: February 2024

Background: Observational studies suggest a potential association between atmospheric particulate matter 2.5 (PM2.5) and osteoporosis, but a causal association is unclear due to the presence of confounding factors.Methods: We utilized bone mineral density indices at four specific sites to represent osteoporosis: femoral neck (FN-BMD), lumbar spine (LS-BMD), forearm (FA-BMD), and heel (HE-BMD). The PM2.5 data was obtained from the UK Biobank database, while the datasets for FN-BMD, LS-BMD, and FA-BMD were obtained from the GEFOS database, and the dataset for HE-BMD was obtained from the EBI database. A two-sample Mendelian randomization analysis was conducted using mainly the inverse variance weighted method, horizontal pleiotropy and heterogeneity were also assessed.Results: The results indicated that PM2.5 was not correlated with a decrease in FN-BMD (β: −0.305, 95%CI: −0.762, 0.153), LS-BMD (β: 0.134, 95%CI: −0.396, 0.666), FA-BMD (β: -0.056, 95%CI: −1.172,1.060), and HE-BMD (β: −0.084, 95%CI: −0.261,0.093). Additionally, acceptable levels of horizontal pleiotropy and heterogeneity were observed.Conclusion: In contrast to most observational studies, our research did not discover a potential causal relationship between PM2.5 and the development of osteoporosis.
Trends in cognitive function before and after myocardial infarction: findings from the China Health and Retirement Longitudinal Study
Authors: Shang Jing , Dong Jianye , Zhu Sijia , Chen Qingmei , Hua Jianian 
Published: February 2024

ObjectivesIncident stroke was associated with cognitive dysfunction after stroke and even before stroke. However, cognitive trends prior to myocardial infarction (MI) and the timeline of cognitive decline in a few years following incident MI remain unclear, especially among the Chinese population. We aimed to evaluate whether MI was associated with cognitive change both before and after MI in China.MethodsThis cohort study included 11,287 participants without baseline heart problems or stroke from the China Health and Retirement Longitudinal Study. The exposure was self-reported MI. The outcomes were scores of cognitive functions in five domains, which reflected abilities of episodic memory, visuospatial abilities, orientation, attention and calculation, and global cognition as a summary measure. A Linear mixed model was constructed to explore cognitive function before and after incident MI among the MI participants and the cognitive trends of participants free of MI.ResultsDuring the 7-year follow-up, 421 individuals [3.7% of 11,287, mean (SD) age, 60.0 (9.0) years; 59.1% female] experienced MI events. The cognitive scores of participants of both the MI group and the control group without MI declined gradually as time went by. The annual decline rate of the MI group before incident MI was similar to that of the control group during the whole follow-up period. Incident MI was not associated with acute cognitive decline in all five cognitive domains. Moreover, MI did not accelerate the cognitive decline rate after MI compared with the pre-MI cognitive trends. The decline rate of cognitive function after MI was similar to the rate before MI.ConclusionsDifferent from stroke, participants who had an MI did not show steeper cognitive decline before MI. MI was not associated with acute cognitive decline and accelerated decline in several years after MI. Future studies are needed to learn the mechanisms behind the different patterns of cognitive decline between MI and stroke.