bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the value of radiomics stemming from DSC quantitative biomarkers in IDH mutation prediction in gliomas
Authors: Ioannidis Georgios S. , Pigott Laura Elin , Iv Michael , Surlan-Popovic Katarina , Wintermark Max , Bisdas Sotirios , Marias Kostas 
Published: November 2023

ObjectiveThis study aims to assess the value of biomarker based radiomics to predict IDH mutation in gliomas. The patient cohort consists of 160 patients histopathologicaly proven of primary glioma (WHO grades 2–4) from 3 different centers.MethodsTo quantify the DSC perfusion signal two different mathematical modeling methods were used (Gamma fitting, leakage correction algorithms) considering the assumptions about the compartments contributing in the blood flow between the extra- and intra vascular space.ResultsThe Mean slope of increase (MSI) and the K1 parameter of the bidirectional exchange model exhibited the highest performance with (ACC 74.3% AUROC 74.2%) and (ACC 75% AUROC 70.5%) respectively.ConclusionThe proposed framework on DSC-MRI radiogenomics in gliomas has the potential of becoming a reliable diagnostic support tool exploiting the mathematical modeling of the DSC signal to characterize IDH mutation status through a more reproducible and standardized signal analysis scheme for facilitating clinical translation.
High-sensitive cardiac troponin I (hs-cTnI) concentrations in newborns diagnosed with spinal muscular atrophy
Authors: Johannsen Jessika , Weiss Deike , Driemeyer Joenna , Olfe Jakob , Stute Fridrike , Müller Ferdinand , Schütt Marion , Trollmann Regina , Kölbel Heike , Schara-Schmidt Ulrike , Kirschner Janbernd , Pechmann Astrid , Blaschek Astrid , Horber Veronka , Denecke Jonas 
Published: November 2023

BackgroundSpinal muscular atrophy (SMA) is a genetic neurodegenerative disease leading to muscular weakness and premature death. Three therapeutic options are currently available including gene replacement therapy (GRT), which is potentially cardiotoxic. High-sensitive cardiac troponin I (hs-cTnI) is widely used to monitor potential cardiac contraindications or side effects of GRT, but reference data in healthy newborns are limited and lacking in neonates with SMA. The aim of this study is to determine the range of pre-therapeutic hs-cTnI concentrations in neonates with SMA and to provide guidance for the assessment of these values.MethodsHs-cTnI levels, genetic and clinical data of 30 newborns (age range 2–26 days) with SMA were retrospectively collected from 6 German neuromuscular centers. In addition, hs-cTnI levels were measured in 16 neonates without SMA.ResultsThe median hs-cTnI concentration in neonates with SMA was 39.5 ng/L (range: 4–1205). In 16 newborns with SMA, hs-cTnI levels were above the test-specific upper reference limit (URL). Exploratory statistical analysis revealed no relevant correlation between hs-cTnI levels and gender, gestational age, mode of delivery, SMN2 copy number, symptoms of SMA or abnormal cardiac findings.DiscussionOur results suggest higher hs-cTnI plasma levels in newborns with and without SMA compared to assay-specific reference values generated in adults. Given the wide range of hs-cTnI values in neonates with SMA, hs-cTnI levels must be determined before treatment in each patient and post-treatment elevations should be interpreted in the context of the course rather than as individual values.
Intranasal dexmedetomidine improves postoperative sleep quality in older patients with chronic insomnia: a randomized double-blind controlled trial
Authors: Wu Jinghan , Liu Xingyang , Ye Chunyan , Hu Jiajia , Ma Daqing , Wang E. 
Published: November 2023

Objective: This study was determined to investigate the impact of intranasal dexmedetomidine (DEX) on postoperative sleep quality in older patients (age over 65) with chronic insomnia during their hospitalization after surgery.Design: A randomized double-blind controlled trial was conducted to compare the effects of intranasal dexmedetomidine spray with a placebo group.Setting and Participants: The study was carried out at Xiangya Hospital, Central South University. 110 participants with chronic insomnia were analyzed.Methods: This trial enrolled older patients who underwent total hip/knee arthroplasty and randomized them to receive intranasal dexmedetomidine (2.0 μg/kg) or saline daily at around 9 p.m. after surgery until discharge. The primary outcomes were subjective sleep quality assessed with the Leeds Sleep Evaluation Questionnaire (LSEQ). The secondary outcomes included the objective sleep quality measured with the Acti-graph, the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI). The other outcomes included the incidence of delirium, levels of inflammatory factors, visual analog scale (VAS) pain scores, postoperative opioid consumption, and treatment-related adverse events.Results: 174 patients were screened for eligibility, and 110 were recruited and analyzed. The DEX group had significantly higher scores on both the LSEQ-Getting to sleep and LSEQ-Quality of Sleep at each time point compared to the placebo (p &lt; 0.0001), The least squares (LS) mean difference in LSEQ-GTS score at T0 between placebo group and DEX group was 2 (95% CI, −1–6), p = 0.4071 and at T5 was −14 (95% CI, −17 to −10), p &lt; 0.0001; The LS mean difference in the LSEQ-QOS score at T0 was −1 (95% CI, −4 to 1), p = 0.4821 and at T5 was −16 (95% CI, −21 to −10), p &lt; 0.0001. The DEX group exhibited significant improvement in Total Sleep Time (TST), Sleep Onset Latency (SOL), and Sleep Efficiency (SE), at each time point after treatment compared to the placebo group (p &lt; 0.0001). The PSQI and ISI scores in the DEX group were reduced after treatment (p &lt; 0.001). No significant adverse events were reported with the use of dexmedetomidine.Conclusion and Implications: This study demonstrates that intranasal administration of dexmedetomidine improves postoperative sleep quality in older patients with chronic insomnia who undergo surgery, without increasing the incidence of adverse effects.Clinical Trial Registration:http://www.chictr.org.cn/, identifier ChiCTR2200057133
Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiotherapy (CPFR)
Authors: Di Martino F. , Del Sarto D. , Bass G. , Capaccioli S. , Celentano M. , Coves D. , Douralis A. , Marinelli M. , Marrale M. , Masturzo L. , Milluzzo G. , Montefiori M. , Paiar F. , Pensavalle J. H. , Raffaele L. , Romano F. , Subiel A. , Touzain E. , Verona Rinati G. , Felici G. 
Published: November 2023

The FLASH effect is a radiobiological phenomenon that has garnered considerable interest in the clinical field. Pre-clinical experimental studies have highlighted its potential to reduce side effects on healthy tissues while maintaining isoeffectiveness on tumor tissues, thus widening the therapeutic window and enhancing the effectiveness of radiotherapy. The FLASH effect is achieved through the administration of the complete therapeutic radiation dose within a brief time frame, shorter than 200 milliseconds, and, therefore, utilizing remarkably high average dose rates above at least 40 Gy/s. Despite its potential in radiotherapy, the radiobiological mechanisms governing this effect and its quantitative relationship with temporal parameters of the radiation beam, such as dose-rate, dose-per-pulse, and average dose-rate within the pulse, remain inadequately elucidated. A more profound comprehension of these underlying mechanisms is imperative to optimize the clinical application and translation of the FLASH effect into routine practice. Due to the aforementioned factors, the undertaking of quantitative radiobiological investigations becomes imperative, necessitating the utilization of sophisticated and adaptable apparatus capable of generating radiation beams with exceedingly high dose-rates and dose-per-pulse characteristics. This study presents a comprehensive account of the design and operational capabilities of a Linear Accelerator (LINAC) explicitly tailored for FLASH radiotherapy research purposes. Termed the “ElectronFlash” (EF) LINAC, this specialized system employs a low-energy configuration (7 and 9 MeV) and incorporates a triode gun. The EF LINAC is currently operational at the Centro Pisano FLASH Radiotherapy (CPFR) facility located in Pisa, Italy. Lastly, this study presents specific instances exemplifying the LINAC’s adaptability, enabling the execution of hitherto unprecedented experiments. By enabling independent variations of the temporal parameters of the radiation beam implicated in the FLASH effect, these experiments facilitate the acquisition of quantitative data concerning the effect’s dependence on these specific parameters. This novel approach hopefully contributes to a more comprehensive understanding of the FLASH effect, shedding light on its intricate radiobiological behavior and offering valuable insights for optimizing its clinical implementation.
Early bruising detection of ‘Korla’ pears by low-cost visible-LED structured-illumination reflectance imaging and feature-based classification models
Authors: Mei Mengwen , Cai Zhonglei , Zhang Xinran , Sun Chanjun , Zhang Junyi , Peng Huijie , Li Jiangbo , Shi Ruiyao , Zhang Wei 
Published: November 2023

IntroductionNondestructive detection of thin-skinned fruit bruising is one of the main challenges in the automated grading of post-harvest fruit. The structured-illumination reflectance imaging (SIRI) is an emerging optical technique with the potential for detection of bruises.MethodsThis study presented the pioneering application of low-cost visible-LED SIRI for detecting early subcutaneous bruises in ‘Korla’ pears. Three types of bruising degrees (mild, moderate and severe) and ten sets of spatial frequencies (50, 100, 150, 200, 250, 300, 350, 400, 450 and 500 cycles m-1) were analyzed. By evaluation of contrast index (CI) values, 150 cycles m-1 was determined as the optimal spatial frequency. The sinusoidal pattern images were demodulated to get the DC, AC, and RT images without any stripe information. Based on AC and RT images, texture features were extracted and the LS-SVM, PLS-DA and KNN classification models combined the optimized features were developed for the detection of ‘Korla’ pears with varying degrees of bruising.Results and discussionIt was found that RT images consistently outperformed AC images regardless of type of model, and LS-SVM model exhibited the highest detection accuracy and stability. Across mild, moderate, severe and mixed bruises, the LS-SVM model with RT images achieved classification accuracies of 98.6%, 98.9%, 98.5%, and 98.8%, respectively. This study showed that visible-LED SIRI technique could effectively detect early bruising of ‘Korla’ pears, providing a valuable reference for using low-cost visible LED SIRI to detect fruit damage.
Resilience mediates the effect of the COVID-19 pandemic on mental health in a sample of adults in Panama
Authors: Oviedo Diana C. , Tratner Adam E. , Pinzón María Sofía , Rodríguez-Araña Sofía , Pauli-Quirós Elianne , Chavarría Carlos , Rodríguez Camilo Posada , Britton Gabrielle B. 
Published: November 2023

BackgroundThe COVID-19 pandemic was characterized by global increases in depression, anxiety, and stress symptoms. Previous studies have shown that resilience mitigates these symptoms, however there is limited research exploring the link between resilience and mental illness during the COVID-19 pandemic in Central America.ObjectiveTo examine the role of resilience as it relates to the perceived effect of the pandemic on mental health symptoms.MethodsA sample of 480 adults in Panama were recruited from March to May 2021 to complete an online survey. The online survey consisted of sociodemographic questions and scale measures assessing depression, anxiety and stress symptoms, resilience, and social support.ResultsResults indicated that resilience mediated the relationship between the perceived effect of the COVID-19 pandemic and mental health symptoms; participants who felt more personally affected by the pandemic reported more depression, anxiety, and stress symptoms via decreased resilience. Further analyses revealed that resilience was moderated by sex and social support, showing that the indirect effect of resilience was greater for women and individuals who perceived low social support.DiscussionThese findings contribute to a growing body of research documenting the adverse effects of the COVID-19 pandemic on mental health and reveal potential mechanisms through which pandemic-related distress decreases resilience, thereby increasing symptoms of mental illness.
Psychological resilience and work engagement of Chinese nurses: a chain mediating model of career identity and quality of work life
Authors: Meng Zhixing , Zhang Lan , Zan Haijing , Wang Jingru 
Published: November 2023

AimTo investigate how nurses’ psychological resilience affects their work engagement and the resulting pathways, namely, the intermediary effect of career identity and quality of work life.BackgroundPsychological resilience is the ability to adapt to new circumstances and overcome difficulties. Work engagement is a positive, perfect emotional and cognitive state in the work process, which has a positive effect on nurses’ physical and mental health and career development. The importance of psychological resilience in nursing is growing in popularity. However, few studies have explored the relationship between psychological resilience and nurses’ work engagement.DesignThis is a cross-sectional study.MethodsFrom March to April 2023, 356 nurses in the First Affiliated Hospital of Jinzhou Medical University in China received valid questionnaires. The study was surveyed using the Connor-Davidson, Resilience Scale, the Nursing Career Identity Scale, the Work-Related Quality of Life Scale, and the 15-item Utrecht Work Engagement Scale. Process version 3.5 plug-in SPSS 25 was used to test the mediating effect.Results(1) Psychological resilience was significantly and positively correlated with career identity, quality of work life, and work engagement (r = 0.702–0.803, p &lt; 0.001). (2) Career identity and quality of work life partially mediated the relationship between psychological resilience and work engagement, with effect sizes of 0.2382 and 0.0958, respectively. (3) There was a chain mediation model between psychological resilience and work engagement that had a value of 0.1219.ConclusionCareer identity and quality of work life played a chain-mediating role between psychological resilience and work engagement. Thus, in order to enhance the work engagement of clinical nurses, it is necessary for nursing managers to take measures to enhance not only psychological resilience but also their career identity and the quality of work life.
The effect of a single-session heart rate variability biofeedback on attentional control: does stress matter?
Authors: Blaser Berenike L. , Weymar Mathias , Wendt Julia 
Published: November 2023

IntroductionVagally mediated heart rate variability is an index of autonomic nervous system activity that is associated with a large variety of outcome variables including psychopathology and self-regulation. While practicing heart rate variability biofeedback over several weeks has been reliably associated with a number of positive outcomes, its acute effects are not well known. As the strongest association with vagally mediated heart rate variability has been found particularly within the attention-related subdomain of self-regulation, we investigated the acute effect of heart rate variability biofeedback on attentional control using the revised Attention Network Test.MethodsFifty-six participants were tested in two sessions. In one session each participant received a heart rate variability biofeedback intervention, and in the other session a control intervention of paced breathing at a normal ventilation rate. After the biofeedback or control intervention, participants completed the Attention Network Test using the Orienting Score as a measure of attentional control.ResultsMixed models revealed that higher resting baseline vagally mediated heart rate variability was associated with better performance in attentional control, which suggests more efficient direction of attention to target stimuli. There was no significant main effect of the intervention on attentional control. However, an interaction effect indicated better performance in attentional control after biofeedback in individuals who reported higher current stress levels.DiscussionThe results point to acute beneficial effects of heart rate variability biofeedback on cognitive performance in highly stressed individuals. Although promising, the results need to be replicated in larger or more targeted samples in order to reach stronger conclusions about the effects.
Distress in the care of people with chronic low back pain: insights from an ethnographic study
Authors: Dillon Miriam , Olson Rebecca E. , Plage Stefanie , Miciak Maxi , Window Peter , Stewart Matthew , Christoffersen Anja , Kilner Simon , Barthel Natalie , Setchell Jenny 
Published: November 2023

IntroductionDistress is part of the experiences and care for people with chronic low back pain. However, distress is often pathologised and individualised; it is seen as a problem within the individual in pain and something to be downplayed, avoided, or fixed. To that end, we situate distress as a normal everyday relational experience circulating, affecting, moving in, through, and across bodies. Challenging practices that may amplify distress, we draw on the theorisation of affect as a relational assemblage to analyse physiotherapy clinical encounters in the care of people with chronic low back pain.MethodsAdopting a critical reflexive ethnographic approach, we analyse data from a qualitative project involving 15 ethnographic observations of patient-physiotherapist interactions and 6 collaborative dialogues between researchers and physiotherapists. We foreground conceptualisations of distress— and what they make (im)possible—to trace embodied assemblage formations and relationality when caring for people with chronic low back pain.ResultsOur findings indicate that conceptualisation matters to the clinical entanglement, particularly how distress is recognised and navigated. Our study highlights how distress is both a lived experience and an affective relation—that both the physiotherapist and people with chronic low back pain experience distress and can be affected by and affect each other within clinical encounters.DiscussionSituated at the intersection of health sociology, sociology of emotions, and physiotherapy, our study offers a worked example of applying an affective assemblage theoretical framework to understanding emotionally imbued clinical interactions. Viewing physiotherapy care through an affective assemblage lens allows for recognising that life, pain, and distress are emerging, always in flux. Such an approach recognises that clinicians and patients experience distress; they are affected by and affect each other. It demands a more humanistic approach to care and helps move towards reconnecting the inseparable in clinical practice—emotion and reason, body and mind, carer and cared for.
INCREASING THE PERFORMANCE CHARACTERISTICS OF GYPSUM COMPOSITE FOR DECORATIVE PRODUCTS
Authors: Mokrova M. , Sardarova S. 
Published: November 2023

The article discusses the results of research on the use of modifying additives in gypsum binder. Regulation of the structure and, therefore, the properties of gypsum stone can be carried out using small quantities of highly active additives that can effectively influence the formation of the structure of gypsum stone, and, consequently, its characteristics. Using functional modifying additives in small quantities, which practically do not affect the cost of the material, and using them to control the composition of gypsum binders, it is possible to obtain effective decorative and finishing gypsum products with improved characteristics.
The work studied the effect of polyvinyl acetate additives together with synthetic polypropylene fiber on the properties of gypsum stone products. A comparison of the physical and mechanical characteristics of modified gypsum composites is presented, and the advantages of introducing fiber are revealed. By covering the pores and capillaries of gypsum stone with fiber fibers, the formation of shrinkage microcracks is significantly reduced, crack resistance increases, and strength characteristics increase.
It has been established that modification of gypsum stone with polyvinyl acetate together with synthetic fibers helps to improve the physical and mechanical characteristics of gypsum stone. The developed compositions of decorative and finishing gypsum tiles using the additions of polyvinyl acetate and polypropylene fiber make it possible to obtain gypsum finishing materials products with improved characteristics, which demonstrates their increased efficiency as a modern finishing material and opens up broad prospects for use in housing and civil construction.
Sultan II. Osman’ın Katli ve Olayın Üzerine Abaza Mehmed Paşa Ağzından Söylenmiş Bir Şiir
Authors: ÜNLÜ Osman , AYSOY Mehmet 
Published: November 2023

Osmanlı İmparatorluğu’nun yaklaşık 600 yıl süren siyasi ömründe çeşitli iniş ve çıkışlar bulunmaktadır. Zafer ve fetihlerin yanı sıra mağlubiyet ve toprak kayıpları olmuştur. Bunun yanında siyasi mücadeleler veya halkın devlet yönetiminden hoşnutsuzluğu sebebiyle bazı idamlar yapılmış veya isyanlar da çıkmıştır.
Osmanlı’nın en trajik isyanlarından biri de 1622 yılında sultan II. Osman’ın çıkan yeniçeri isyanı sonrasında tahttan indirilmesi ve akabinde öldürülmesidir. Olayın meydana geldiği dönemde bu olayın üzerine gerek tarihçilerin gerekse şairlerin yeterince durmadıkları görülmektedir. Padişahın öldürülmesinden kısa bir süre sonra isyan eden Abaza Mehmed Paşa’nın geçici ve göreceli olarak başarı sağlaması sonrasında dönemin padişahı IV. Murad tarafından affedilmiştir. Abaza Mehmed Paşa’nın bu hareketi halk arasında yayılmış, konuyla alakalı onun ağzından bir şiir de söylenmiştir.
Bu yazıda, olayın genel bir görünümü verildikten sonra Abaza Mehmed Paşa’nın kendi ağzından yazılmış olan bir üzerine inceleme yapılmıştır.
Origin of different electrical conductivities in PEDOT:PSS
Authors: Jing Yuxin , Fukasawa Yusuke , Okuzaki Hidenori 
Published: November 2023

Abstract
The different grades of poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) (Clevios P, PH500, and PH1000) were investigated to clarify the origin of the different electrical conductivities using X-ray photoelectron spectroscopy, dynamic light scattering, reflectance spectroscopy, X-ray diffraction, conductive atomic force microscopy, and Raman spectroscopy. The electrical conductivity (σ), crystallinity (X
c), and carrier mobility (μ) increased in the order of Clevios P, PH500, and PH1000, whereas the composition ratio (α) and carrier density (N
c) were almost the same. The results allowed us to conclude that the mechanism of different σ in the PEDOT:PSS lay in μ, where high X
c with large size (D
nc) and number (N
nc) of PEDOT nanocrystals uniformly distributed within the PSS matrix favored carrier transport between adjacent nanocrystals, resulting in high σ in the bulk state.