bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemicals profiling, in vitro and in vivo antidiabetic activity, and in silico studies on Ajuga iva (L.) Schreb.: A comprehensive approach
Authors: Abomughaid Mosleh M. , El-Shibani Fatma A. A. , Abdulkarim Abdulnaser Kh. , Abouzied Amr S. , Sulaiman Ghassan M. , Abomughayedh Ali M. , Abdulsayid Munira M. F. , Albukhaty Salim , Elrmali Naema , Al-Saffar Ali Z. , El-khawaga Hend A. , Mohammed Hamdoon A. 
Published: January 2024

Abstract

Ajuga iva (L.) Schreb. is a well-known antidiabetic medicinal plant used for several traditional medicine aspects in different areas of the world, including Libya. This study includes phytochemical analysis, antidiabetic evaluation, and in silico studies of the plant, A. iva, growing in Libya. The constituents of the plant were profiled using LC-MS/MS-QTOF analysis, and a total of 28 compounds were tentatively identified, including engeletin, pyrocatechol, eriodyctiol-7-hexoside, and 3,4-dihydroxybenzaldehyde, as major constituents. In addition, the steroidal compounds, i.e., 20-hydroxyecdysone, 24-dehydroprecyasterone, makisterone A, and ajugasterone D, which are considered chemomarkers for the plant, were also annotated by LC-MS analysis. The plant extract induced inhibition of α-amylase and α-glucosidase enzymes at IC50 values of 0.18 and 0.12 mg/mL, compared to the IC50 of the standard acarbose at 0.11 and 0.09 mg/mL, respectively. Fasting blood glucose (FBG, 360.7 mg/dL) levels were significantly reduced by the treatment of streptozotocin (STZ)-diabetic animals with 400 mg/kg (140.5 mg/dl) and 500 mg/kg (112.3 mg/dL) doses of the plant extract. The plant extract also induced a significant (p < 0.01) increase in insulin serum level compared to the untreated diabetic rats; however, the higher dose of the plant induced similar insulin induction compared to glibenclamide. Histopathological examination of the pancreatic and liver tissues indicated that A. iva extract induced regeneration in the islets of Langerhans and liver cells compared to the untreated diabetic rats. Docking analysis demonstrated that eriodyctiol-7-hexoside, echinacoside, and 2″-galloylhyperin showed the lowest binding energies to the target sites of α-amylase and α-glucosidase enzymes, indicating their potential role in A. iva antidiabetic bioactivities. The results support the recorded traditional bioactivity of A. iva as an antidiabetic herb, whereas its contents of polyphenols play a major role in the plant’s antidiabetic effect.
Enhancing weld strength in high-strength steels: the role of regional preheating in RSW
Authors: Aydin Kemal , Hıdıroğlu Mehtap , Kahraman Nizamettin 
Published: January 2024

Abstract
In this study, automotive in sector use STRENX 700 CR and DP 800 steels were joined by resistance spot welding using medium frequency direct current. Some parts were joined under atmospheric conditions, while others were joined by applying regional preheating to their heat-affected zones before welding. The design, manufacturing, and adaptation of the preheating system to the welding machine were carried out as part of this study, considering it as a new system. After the joining process, nondestructive and destructive tests were performed on resistance spot welding connections between STRENX 700 CR and DP 800 steels. Hardness tests revealed that the preheating applied to the heat-affected zones before welding reduced the hardness of the weld metal by approximately 8 %, while the microstructure analysis showed that the regional preheating increased both the weld metal and the heat-affected zones width. The tensile-shear strength increased by about 7 %, and the cross-tension test strength increased by about 5 % with the preheating applied to the heat-affected zones before welding. In both the tensile-shear and cross-tension tests, all failures occurred in the form of button shearing from the heat-affected zones. The regional preheating treated specimens showed the highest fatigue life, with an average of 947,632 cycles.
Efficient radiative cooling of low-cost BaSO4 paint-paper dual-layer thin films
Authors: Felicelli Andrea , Wang Jie , Feng Dudong , Forti Endrina , El Awad Azrak Sami , Peoples Joseph , Youngblood Jeffrey , Chiu George , Ruan Xiulin 
Published: January 2024

Abstract
Many materials have been explored for the purpose of creating structures with high radiative cooling potential, such as nanocellulose-based structures and nanoparticle-based coatings, which have been reported with environmentally friendly attributes and high solar reflectance in current literature. They each have their own advantages and disadvantages in practice. It is worth noting that nanocellulose-based structures have an absorption peak in the UV wavelengths, which results in a lower total solar reflectance and, consequently, reduce radiative cooling capabilities. However, the interwoven-fiber structure of cellulose gives high mechanical strength, which promotes its application in different scenarios. The application of nanoplatelet-based coatings is limited due to the need for high volume of nanoparticles to reach their signature high solar reflectance. This requirement weakens the polymer matrix and results in more brittle structures. This work proposes a dual-layer system, comprising of a cellulose-based substrate as the bottom layer and a thin nanoparticle-based radiative cooling paint as the top layer, where both radiative cooling potential and mechanical strength can be maximized. Experimental and theoretical studies are conducted to investigate the relationship between thickness and reflectance in the top coating layer with a consistent thickness of the bottom layer. The saturation point is identified in this relationship and used to determine the optimal thickness for the top-layer to maximize material use efficiency. With the use of cotton paper painted with a 125 μm BaSO4-based layer, the cooling performance is enhanced to be 149.6 W/m2 achieved by the improved total solar reflectance from 80 % to 93 %.
Electrically-switched differential microscopy based on computing liquid-crystal platforms
Authors: Liu Shuoqing , Zheng Dandan , Yang Qiang , Chen Shizhen , Wen Shuangchun , Luo Hailu 
Published: January 2024

Abstract
Detection of transparent phase specimens especially biological cells with desired contrasts is of great importance in visual display and medical diagnosis. Due to the pure-phase nature, conventional detection approaches may damage samples or require complex operations. Computing liquid crystal (LC) is a thin and flat optical element with excellent capability in optical field modulation, which gives a feasible way to this issue from the perspective of analog optical computing. We here propose and experimentally implement an electrically switched two-dimensional (2D) differential microscopy based on computing LC platforms. The Pancharatnam–Berry phase LC polarization grating induces light’s spin separation to promote the 2D differential operation. Using the electrically tunable LC plate as the system phase retardance provider, the detecting mode can be flexibly switched from bright-field images to edge-enhanced images with desired contrasts. Remarkably, owing to the wavelength-independent feature closely related to the geometric phases, our proposed scheme is demonstrated to be applicable to the multi-wavelength microscopy imaging. These results open avenues to form real-time all-optical image processing and may facilitate multifunctional differential microscopy.
Mesenchymal stem cell exosomes: a promising delivery system for glioma therapy
Authors: Ma Tianfei , Su Gang , Wu Qionghui , Shen Minghui , Feng Xinli , Zhang Zhenchang 
Published: January 2024

Abstract
Gliomas are particularly challenging due to their high invasiveness, frequent recurrence, and elevated mortality rates. Despite the availability of treatments like surgery, radiation, and chemotherapy, each of these methods faces significant limitations. This has led to a pressing demand for new strategies against gliomas. In this landscape, mesenchymal stem cells (MSCs) have shown significant potential in recent years. However, the application of MSCs in glioma therapy encounters various challenges. A significant advancement in this field is the utilization of exosomes (Exo), key secretions of MSCs. These exosomes not only carry the benefits inherent in MSCs but also exhibit unique physicochemical properties that make them effective drug carriers. Consequently, MSCs Exo is gaining recognition as a sophisticated drug delivery system, specifically designed for glioma treatment. The scope of MSCs Exo goes beyond being just an innovative drug delivery mechanism; it also shows potential as a standalone therapeutic option. This article aims to provide a detailed summary of the essential role of MSCs Exo in glioma progression and its growing importance as a drug delivery carrier in the fight against this formidable disease.
Synthesis, crystal structure and luminescent properties of a quinary borate-phosphate compound CsNa2Dy2(BO3)(PO4)2
Authors: Liu Kai , Yang Shipeng , Tian Junfeng , Zhang Peixin , Hei Xiaohan , Jiang Zhongfeng 
Published: January 2024

Abstract
Borate-phosphates exhibit a wide range of compositional and structural diversity, making them ideal hosts for luminescent materials. In this work, a new borate-phosphate compound CsNa2Dy2(BO3)(PO4)2 has been prepared under high temperature solution growth method. It crystallizes in an orthorhombic space group Cmcm with the following lattice parameters determined by single-crystal X-ray diffraction: a = 6.9709(5), b = 14.9699(11), c = 10.6480(8) Å, z = 4. Its structure contains isolated BO3 planar triangles and PO4 tetrahedra, which are interconnected by Cs+, Na+ and Dy3+ ions. Solid solutions of CsNa2Y2(1−x)Dy2x
(BO3)(PO4)2 (x = 0 − 0.08) are prepared and exhibit a yellow emissive luminescence by near-UV excitation due to the 4F9/2 → 6H(13/2, 15/2) transitions of Dy3+. The optimized concentration of Dy3+ is x = 0.01, and if over this critical value, the luminescent intensity will decrease due to concentration quenching. The Commission International de L’Eclairage (CIE) coordinates for CsNa2Y1.98Dy0.02(BO3)(PO4)2 are (x = 0.377, y = 0.404), corresponding to yellow color. The prepared phosphor may serve as a yellow phosphor for NUV-excited LEDs.
A corpus-based analysis of light verb constructions with MAKE and DO in British English
Authors: Giparaitė Judita 
Published: January 2024

The comparison of light verb constructions with the verbs make and do has not received much attention. The present paper is an attempt to contribute to the study of these constructions. It aims to analyze the light verbs make and do in combination with the same deverbal nouns to identify similarities and differences between the two light verbs and examine the contribution of the light verbs and deverbal nouns to the light verb construction in terms of semantic and syntactic features. The research is corpus-based, and the data for analysis are collected from the British National Corpus (BNC). The semantic description deals with characteristics such as generality, polysemy and aspectual meaning, and the syntactic description focuses on complementation. The analysis of findings demonstrates that, despite some similarities, almost all constructions with the two light verbs show either meaning or/and complementation differences. The study also reveals that both light verbs and deverbal nouns have an impact on the semantics and syntax of the construction. Light verbs may affect light verb constructions semantically in terms of generality and polysemy, and the aspectual meaning of constructions depends on both light verbs and deverbal nouns. Likewise, both light verbs and deverbal nouns have an influence on complementation, but in their own way: light verbs on the selection of complements and deverbal nouns on complementation patterns.
Role of Age and Competing Risk of Death in the Racial Disparity of Kidney Failure Incidence after Onset of CKD
Authors: Yan Guofen , Nee Robert , Scialla Julia J. , Greene Tom , Yu Wei , Heng Fei , Cheung Alfred K. , Norris Keith C. 
Published: January 2024

Significance Statement
Black adults in the United States have 2–4 times higher incidence of kidney failure than White adults. Yet, the reasons underlying this disparity remain poorly understood. Among 547,188 US veterans with new-onset CKD, according to a new race-free GFR equation, Black veterans had a 2.5-fold higher cumulative incidence of kidney failure, compared with White veterans, in any follow-up period from CKD onset. This disparity resulted from a combination of higher hazards of progression to kidney failure and lower hazards of competing-risk death in Black veterans. Both, in turn, were largely explained by the younger age at CKD onset in Black veterans, underscoring an urgent need to prevent early onset and slow progression of CKD in younger Black adults.

Background
The Black adult population is well known to have higher incidence of kidney failure than their White counterpart in the United States, but the reasons underlying this disparity are unclear. We assessed the racial differences in kidney failure and death from onset of CKD on the basis of the race-free 2021 CKD Epidemiology Collaboration equation and examined the extent to which these differences could be explained by factors at the time of CKD onset.

Methods
We analyzed a national cohort consisting of 547,188 US veterans (103,821 non-Hispanic Black and 443,367 non-Hispanic White), aged 18–85 years, with new-onset CKD between 2005 and 2016 who were followed through 10 years or May 2018 for incident kidney failure with replacement therapy (KFRT) and pre-KFRT death.

Results
At CKD onset, Black veterans were, on average, 7.8 years younger than White veterans. In any time period from CKD onset, the cumulative incidence of KFRT was 2.5-fold higher for Black versus White veterans. Meanwhile, Black veterans had persistently >2-fold higher hazards of KFRT throughout follow-up (overall hazard ratio [95% confidence interval], 2.38 [2.31 to 2.45]) and conversely had 17%–48% decreased hazards of pre-KFRT death. These differences were reduced after accounting for the racial difference in age at CKD onset.

Conclusions
The 2.5-fold higher cumulative incidence of kidney failure in Black adults resulted from a combination of higher hazards of progression to kidney failure and lower hazards of the competing risk of death, both of which can be largely explained by the younger age at CKD onset in Black compared with White adults.
Epilepsy: a cross‐sectional study of paediatricians and general practitioners on their experiences, knowledge and handling of the disease
Authors: Schnabel Sabrina , Neininger Martina Patrizia , Bernhard Matthias Karl , Merkenschlager Andreas , Kiess Wieland , Bertsche Thilo , Bertsche Astrid 
Published: January 2024

ABSTRACTAims: Epilepsy is a life‐changing disease, and patients with epilepsy may face a number of issues. Paediatricians and general practitioners are often the first to be asked for advice. This cross‐sectional study was performed to gain information on the knowledge and experiences of paediatricians and general practitioners on epilepsy.Methods: From September 2015 to July 2017, paediatricians and general practitioners in Leipzig, Germany, were asked to take part in a face‐to‐face interview.Results: Overall, 40 paediatricians and 60 general practitioners participated in the study. A total of 99/100 (99%) kept emergency medication available and 96/100 (96%) would administer it during a seizure. Also, 40/40 (100%) of the paediatricians and 34/60 (57%) of the general practitioners recommended that non‐professionals should administer emergency medication, and 18/40 (45%) of the paediatricians and 35/60 (58%) of the general practitioners would put an object in the patient's mouth during a seizure. With regards to safety precautions, paediatricians mentioned the risks associated with swimming (30/40; 75%) and the potential of falling from a height (23/40; 58%), whereas general practitioners focused on being around vehicles including driving regulations (43/60; 72%).Only 5/60 (8%) of the general practitioners advised that precautions should be taken during swimming. Fatigue/exhaustion was the most common adverse drug event associated with long‐term anticonvulsive therapy mentioned by paediatricians (13/40; 33%) and general practitioners (27/60; 45%). Of all the participants, 23/100 (23%) recommended epilepsy training programmes for patients and families, however, none were able to name a specific programme.Conclusion: Nearly half of the general practitioners did not recommend the use of rescue medication by non‐professionals. This measure, however, can prevent the occurrence of prolonged non‐treatable seizures. Both paediatricians and general practitioners should bear in mind that placing an object in the mouth during a seizure should be avoided due to the risk of additional injury. To reduce the risk of drowning, physicians should recommend safety precautions during swimming. Information on epilepsy training programmes for patients and families should be diffused to all physicians taking care of patients with epilepsy.
Epilepsy surgery in children: no further threat to theory of mind
Authors: Braams Olga B. , Meekes Joost , van Nieuwenhuizen Onno , Schappin Renske , van Rijen Peter C. , Blijd‐Hoogewys Els M.A. , Steffers Maarten , Braun Kees P.J. , Jennekens‐Schinkel Aag 
Published: January 2024

ABSTRACTAims. To investigate whether theory of mind (ToM), an important requirement for adaptive social functioning, is different between children with pharmacologically refractory epilepsy who undergo epilepsy surgery and healthy control children, whether ToM is affected by epilepsy surgery in these children, and whether ToM is associated with demographic or epilepsy variables.Methods. The “ToM storybooks”, a psychometrically sound ToM instrument designed for children, was administered shortly before and 0.5, one and two years after surgery as part of a neuropsychological assessment. Fifteen patients (mean age: 7.1 years) completed the ToM storybooks before and at least twice after surgery. Two sex‐ and age‐matched healthy control children were included per patient. Linear mixed models were used to analyse differences between patients and controls. The association between ToM and demographic, epilepsy and surgical variables was explored.Results. Patients had lower ToM scores than healthy control children, even when corrected for verbal intelligence quotient (VIQ). Epilepsy surgery had neither a harmful nor a favourable effect on ToM. Later epilepsy onset and temporal origin of epilepsy were associated with higher (better) ToM scores relative to earlier epilepsy onset and extra‐temporal epilepsy (including hemispherotomy in one case). Children in whom the amygdala was resected had worse ToM scores.Conclusion. Children with refractory epilepsy have a ToM deficit that may not be accounted for by lower VIQ. Epilepsy surgery does not affect ToM functioning. Younger age at epilepsy onset is associated with poorer ToM, and temporal epilepsy with better ToM. Finally, the amygdala is implicated in ToM deficit. Patients and their parents should be educated about the possible consequences of epilepsy with regards to the development of social cognition and should be guided in order to help improve ToM.
Interictal epileptiform discharges in sleep and the role of the thalamus in Encephalopathy related to Status Epilepticus during slow Sleep
Authors: Gibbs Steve A. , Nobili Lino , Halász Péter 
Published: January 2024

AbstractEEG activation of interictal epileptiform discharges (IEDs) during NREM sleep is a well‐described phenomenon that occurs in the majority of epileptic syndromes. In drug‐resistant focal epilepsy, IED activation seems to be related to slow wave activity (SWA), especially during arousal fluctuations, namely phase A of the cyclic alternating pattern (CAP). Conversely, in childhood focal epileptic syndromes, including Encephalopathy related to Status Epilepticus during slow Sleep (ESES), IED activation seems primarily modulated by sleep‐inducing and maintaining mechanisms as reflected by the dynamics of spindle frequency activity (SFA) rather than SWA. In this article, we will review the effect of sleep on IEDs with a particular attention on the activation and modulation of IEDs in ESES. Finally, we will discuss the role of the thalamus and cortico‐thalamic circuitry in this syndrome.
Encephalopathy related to Status Epilepticus during slow Sleep: a link with sleep homeostasis?
Authors: Rubboli Guido , Huber Reto , Tononi Giulio , Tassinari Carlo Alberto 
Published: January 2024

AbstractEncephalopathy related to Status Epilepticus during slow Sleep (ESES) is a childhood epilepsy syndrome characterized by appearance of cognitive and behavioural disturbances in conjunction with a striking activation of EEG epileptic abnormalities during sleep. The link between the extreme amount of epileptic discharges during sleep and the deterioration of cognitive functions and behavior is poorly understood. We hypothesize that the negative effects of ESES may depend on the impairment of the synaptic homeostasis processes occurring during normal sleep and that are particularly important in the developmental age. Sleep ensures synaptic homeostasis by promoting synaptic weakening/elimination after the increase of synaptic strength that occurs during wakefulness. Changes in synaptic strength are reflected in the EEG by changes of sleep slow wave activity (SWA). Recent studies in ESES have failed to show changes of sleep SWA, particularly at the site of the epileptic focus, suggesting a spike‐related impairment of the homeostatic recovery of sleep. This impaired synaptic homeostasis in the critical period of development may alter cortical wiring and thereby disrupt, often irreversibly, cognitive functions and behavior, leading to the neuropsychological compromise typical of ESES.
Encephalopathy related to Status Epilepticus during slow Sleep: current concepts and future directions
Authors: Tassinari Carlo Alberto , Rubboli Guido 
Published: January 2024

AbstractWe present some aspects relevant to the definition and diagnosis of Encephalopathy related to Status Epilepticus during slow Sleep (ESES) to further understand the pathophysiological mechanisms in the light of current knowledge and some recent research. Future lines of research in ESES that include investigation of impairment of sleep homeostasis and disruption of age‐related plasticity processes in the developmental age are also discussed.
Abdominal epilepsia partialis continua in neurocysticercosis
Authors: Asranna Ajay , Sureshbabu Sachin , Mittal Gaurav , Peter Sudhir , Chindripu Shobhana , Saini Leena 
Published: January 2024

ABSTRACTEpilepsia partialis continua (EPC) of abdominal muscles is a rare entity with variable clinical localization and aetiology. A 25‐year‐old man presented with sudden onset of intermittent focal myoclonic movements involving the abdominal muscles on the right side exclusively, lasting from 20 minutes to an hour. Brain MRI revealed a ring‐enhancing lesion, suggestive of cysticercal granuloma over the left precentral gyrus. The patient fulfilled the revised diagnostic criteria for definitive diagnosis of neurocysticercosis. EEG did not show focal abnormalities during the events. Episodes of EPC were controlled with difficulty using 600 mg oxcarbazepine, 200 mg lacosamide, and 2,000 mg levetiracetam. The patient received antiparasitic therapy with albendazole (15 mg/kg for two weeks) and oral dexamethasone (0.1 mg/kg) for two weeks which was then tapered. The involvement of the primary motor cortex during ictal propagation may account for this curious phenomenon. This is the first report of abdominal EPC in a patient with inflammatory granuloma as a result of neurocysticercosis.