bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociative experiences alter resting state functional connectivity after childhood abuse
Authors: von Schröder Claudius , Nkrumah Richard O. , Demirakca Traute , Ende Gabriele , Schmahl Christian 
Published: February 2025

Abstract
Dissociative experiences commonly occur alongside adverse childhood experiences (ACE), yet research on their neurofunctional biomarkers has overlooked their unique association with dimensions of childhood abuse and neglect. We investigated interactions between dissociative experiences and childhood abuse, anticipating anti-correlations between the right-lateralized anterior middle frontal gyrus (raMFG) and the medial temporal lobe, as well as the temporal gyri. Examining resting-state functional connectivity in 91 participants with a history of ACE, we employed seed-to-voxel analyses seeding the raMFG. Multiple linear regression and post-hoc moderation/mediation models explored interactions and individual effects of dissociation and dimensions of ACE. The Dissociative Experiences Scale (DES) and Childhood Trauma Questionnaire (CTQ) quantified dissociation and dimensions of ACE. A DES by CTQ-A (childhood abuse) interaction predicted an anti-correlation between the raMFG and right hippocampus, moderated by CTQ-A. The CTQ revealed negative connectivity between the raMFG and right anterior cingulate cortex. CTQ-N (childhood neglect) indicated that both the right supplementary motor area and right insula related positively to the raMFG. Our findings underscore a distinct neural signature of childhood abuse-related dissociative experiences, potentially linked to dissociated memories.
Dissociable genetic influences on eye movements during abstract versus naturalistic social scene viewing in infancy
Authors: Portugal Ana Maria , Taylor Mark J. , Tammimies Kristiina , Ronald Angelica , Falck-Ytter Terje 
Published: February 2025

Abstract
Eye-movement metrics like fixation location and duration are increasingly being used in infancy research. We tested whether fixation durations during meaningful social stimulus viewing involve common or different familial influences than fixation durations during viewing of abstract stimulus. We analysed the duration of fixations, and the allocation of fixations to face and motion, from 536 dizygotic and monozygotic 5-month-old twins in: naturalistic scenes including low- and high-level social features, and abstract scenes only having low-level features. We observed significant genetic influences in both conditions (h
2

naturalistic
= 0.30, 95% confidence interval (CI) 0.14 to 0.44; h
2

abstract
= 0.25, 95% CI 0.09 to 0.39), while shared environmental influences were negligible. Although some genetic influences were shared between the two conditions, unique genetic factors were linked to naturalistic scene viewing, indicating that fixation durations index different phenomena dependent on the context. Heritability for face looking was moderate (h
2 = 0.19, 95% CI 0.03 to 0.34), and no familial influences were found for motion looking. Exploratory polygenic score analyses revealed no significant associations with fixation measures. This study underscores the dissociable genetic influences on infants’ visual exploration of abstract versus naturalistic stimuli and the importance of considering context when interpreting eye-tracking data.
Micro-computed tomographic analysis of the morphology of maxillary canines
Authors: Wolf Thomas Gerhard , Rempapi Theodora , Armogida Niccolò Giuseppe , Spagnuolo Gianrico , Waber Andrea Lisa 
Published: February 2025

Abstract
Objective: This study aimed to examine the morphology of maxillary canines (MxCs) by means of micro-computed tomography (micro-CT). Materials and methods: The root canal configurations (RCCs) of 97 maxillary canines of a mixed Swiss-German population were analyzed using micro-CT. After representing the internal morphology by 3-D software imaging, the RCC results were described using a four-digit system code indicating the main root canal from coronal to apical thirds and the main foramina number. Results: The most frequently observed RCCs of the MxC of the Swiss-German population were 1-1-1/1 (77.3%), followed by 1-1-1/2 (14.4%), 1-1-2/2 (4.1%), and finally 1-1-1/3 and 1-2-1/1 with 2.1% each. One physiological foramen was observed in 79.4% of the samples, two in 18.6%, and only 2.1% had three foramina. In 52.6% of the MxC samples, accessory and connecting canals were identified, with the majority located in the apical third of the root. Conclusions: This study contributes detailed information about the RCCs of MxC. The most prevalent RCC is 1-1-1/1, with accessory or connecting canals present in over half of the samples. However, it is noteworthy that in more than one-fifth of the examined samples, a particularly challenging RCC was observed. This should be considered when selecting treatment techniques. Clinical relevance: This study presents the root canal configurations in maxillary canines of a Swiss-German population and emphasizes the importance of influencing endodontic treatment decisions and outcomes.
Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N-acetyl parabenzoquinone imine and its antidote, N-acetyl-l-cysteine
Authors: El-Abassy Omar M , Fawzy Michael Gamal , Kamel Ebraam B. 
Published: February 2025

Abstract
Acetaminophen, also known as paracetamol (APAP), is a highly utilized pharmaceutical agent on a global scale, particularly in the field of pediatrics. Regrettably, an overdose of APAP, resulting from the predominant oxidation, has the potential to trigger acute liver injury. The study’s goal was to find an easy, accurate, and selective way to measure APAP, N-acetyl para benzoquinone imine (NAPQI) (an APAP metabolite that is harmful), and N-acetyl-l-cysteine (NAC) (an antidote). Two different chromatographic methods were used. The HPTLC method, which used silica gel 60 F254 as a stationary phase and a developing liquid made up of methanol, ethyl acetate, and glacial acetic acid (8:2:0.2, v/v/v) and a UV detection at 254 nm. The HPLC method was developed using a mobile phase consisting of water, methanol, and formic acid in a proportion of (70:30:0.15, v/v/v). The stationary phase used in the approach was a C18 column. Analytes quantification was established utilizing a UV detector operating at a wavelength of 254 nm. The present methods make it possible to measure the amount of APAP in plasma samples. When it comes to pharmacokinetics or medication levels in children’s plasma, for example, this may be also very helpful. The current methods can quantify NAPQI, which is helpful in figuring out drug concentrations in individuals with APAP intoxication diagnoses. Additionally, the current approaches can estimate NAC as an antidote; as a result, this study is a complete study because it can analyse drug, toxic metabolite, and antidote in one analytical run. Using the innovative blue applicability grade index software, which measures the practicality of procedures, both methodologies were compared with a reported methods. Additionally, the achievement of the eco-friendliness profile of the designed procedures was assessed. Both techniques passed the ICH validation tests.
A mild and scalable one-pot synthesis of N-substituted 2-aminobenzimidazoles via visible light mediated cyclodesulfurization
Authors: Rerkrachaneekorn Tanawat , Annuur Rose Malina , Pornsuwan Soraya , Sukwattanasinitt Mongkol , Wacharasindhu Sumrit 
Published: February 2025

Abstract
A visible light mediated photocatalyst-free synthesis of N-substituted 2-aminobenzimidazoles directly from o-phenylenediamines and isothiocyanates is developed in a one-pot fashion. This one-pot reaction proceeds through three steps: N-substitution of o-phenylenediamines, thiourea formation and visible light mediated cyclodesulfurization. This method enables the rapid and efficient synthesis of structurally diverse N-substituted 2-aminobenzimidazoles, achieving yields up to 92% across 69 examples. The practicality of the reaction is demonstrated by gram-scale synthesis. The key advantages of this method include the use of less toxic solvent in aqueous media, the elimination of photocatalyst, and a simple, practical setup (one-pot, open-flask, and ambient temperature). Mechanistic insights are gathered through control experiments, including light on/off cycles and radical inhibition studies. The results indicate that the reaction involves with radical pathway mediated by visible light.
Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation
Authors: Backhaus Sören J. , Schulz Alexander , Lange Torben , Rösel Simon F. , Schmidt-Schweda Lennart S. , Kutty Shelby , Kowallick Johannes T. , Treiber Julia , Rolf Andreas , Sossalla Samuel , Hasenuß Gerd , Schuster Andreas 
Published: February 2025

Abstract
Latent pulmonary vascular disease is a distinct feature already in the early pathophysiology of masked heart failure with preserved ejection fraction (HFpEF) and associated with reduced right ventricular (RV) functional reserve. We hypothesized that serial real-time cardiovascular magnetic resonance (CMR) imaging at rest and during exercise-stress may detect early progress in pathophysiological alterations in HFpEF. Patients presenting with exertional dyspnoea and signs of diastolic dysfunction (E/e’>8, left ventricular (LV) ejection fraction > 50%) were prospectively enrolled in the HFpEF Stress Trial (NCT03260621). Rest and exercise-stress echocardiography, CMR and right heart catheterisation were performed at baseline. Pulmonary capillary wedge pressure (PCWP) was used for classification of HFpEF (≥ 15/25mmHg at rest/during exercise-stress) and non-cardiac dyspnoea (NCD). Repeat rest and exercise-stress CMR was performed in median 2.94 years after recruitment during which timeframe some HFpEF patients had undergone interatrial shunt device (IASD) implantation. Cardiovascular events were assessed after 4 years.Serial CMR scans were available for NCD n = 10, HFpEF n = 10 and HFpEF with IASD implantation following baseline diagnosis n = 6. RV long axis strain at rest and during exercise-stress decreased in HFpEF (p = 0.007 for both) but neither in NCD nor HFpEF with IASD. In contrast, in NCD, an improvement in LA LAS during exercise-stress (p = 0.028) was noted. There were no functional alterations in HFpEF patients who had undergone IASD implantation. RV functional deterioration may be a pathophysiological feature during early-stage disease progress in HFpEF. In this observational study RV functional deterioration was detected in HFpEF patients only but not patients with NCD and patients with HFpEF that were treated with IASD placement. These findings should next be explored in adequately powered future research trials. Clinicaltrials.gov: NCT03260621 (First posted date 24/08/2017).
Image vaccine against steganography in encrypted domain
Authors: Li Xinran , Wang Zichi 
Published: February 2025

Abstract
This paper investigates on the defense against steganography, and the overall purpose of the study is to design a satisfactory defense scheme in encrypted domain. Image vaccine against steganography is an effective technique to discover the utilization of steganography with extremely high detection accuracy. However, the image owner and vaccine provider are not the same person usually. To meet the requirements of steganography defense and privacy protection simultaneously, this paper proposes a vaccine scheme against steganography for encrypted images. After encrypting the entire data of a original image using a stream cipher, the vaccine data can be injected into the image without knowing the image content. With an encrypted image containing vaccine data, one can decrypt it to obtain the vaccinated image. When steganography is executed on vaccinated image, the utilization of steganography can be discovered in encrypted domain. Experimental results show that the detection accuracy of our scheme on steganography is 100% for all cases. That means the utilization of steganography can be always detected using our scheme. Integrate image vaccine into the imaging process of digital cameras in IoT systems is a potential practical application of our scheme. Non-universal detection mechanism is the potential limitations of this study, and it may be solved by pre-processing original image instead of injecting specific data.
Warming alters plankton body-size distributions in a large field experiment
Authors: Albini Dania , Ransome Emma , Dumbrell Alex J. , Pawar Samraat , O’Gorman Eoin J. , Smith Thomas P. , Bell Thomas , Jackson Michelle C. , Woodward Guy 
Published: February 2025

Abstract
The threat of climate change has renewed interest in the responses of communities and ecosystems to warming, with changes in size spectra expected to signify fundamental shifts in the structure and dynamics of these multispecies systems. While substantial empirical evidence has accumulated in recent years on such changes, we still lack general insights due to a limited coverage of warming scenarios that span spatial and temporal scales of relevance to natural systems. We addressed this gap by conducting an extensive freshwater mesocosm experiment across 36 large field mesocosms exposed to intergenerational warming treatments of up to +8 °C above ambient levels. We found a nonlinear decrease in the overall mean body size of zooplankton with warming, with a 57% reduction at +8 °C. This pattern was broadly consistent over two tested seasons and major taxonomic groups. We also detected some breakpoints in the community-level size-temperature relationship, indicating that the system’s response shifts noticeably above a certain level of warming. These results underscore the need to capture intergenerational responses to large gradients in warming at appropriate scales in time and space in order to better understand the effects of warming on natural communities and ecosystems.
Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity
Authors: Daher Wassim , Le Moigne Vincent , Tasrini Yara , Parmar Shweta , Sexton Danielle L. , Aguilera-Correa John Jairo , Berdal Valentin , Tocheva Elitza I. , Herrmann Jean-Louis , Kremer Laurent 
Published: February 2025

Abstract
Type VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species. Mycobacterium abscessus, encodes only ESX-3 and ESX-4. Here, single and double M. abscessus mutants lacking the main ATPases EccC3 and EccC4 were used to define ESX-3 and ESX-4 contributions to substrate secretion and virulence. Our results demonstrate that EsxG/H secretion depends entirely on ESX-3, whereas both ESX-3 and ESX-4 secrete EsxU/T. Furthermore, two newly identified PE/PPE substrates (MAB_0046/MAB_0047) require ESX-3 for secretion. Functional complementation restored secretion and revealed subpolar localization of these systems. Macrophage infections showed that ESX-3 and ESX-4 contribute to bacterial internalization, phagosomal escape, and intracellular survival. In mice, infections with eccC3- and/or eccC4-deletion mutants resulted in complete survival and reduced bacterial loads in the lungs. These findings demonstrate that both ESX systems drive M. abscessus pathogenicity.
Folded pseudochiral Fermi surface in 4Hb-TaSe2 from band hybridization with a charge density wave
Authors: Watson Matthew D. , Tonelli Andrea , Zerabza Mugerabe , Hayward Sam , Wilkinson Rebecca , Carpene Ettore , Cacho Cephise , De Renzi Valentina , Crampin Simon , Da Como Enrico 
Published: February 2025

Abstract
Stacking of strongly-correlated 2D materials is opening the possibility to demonstrate novel electronic or magnetic ordering phenomena. In this regard the intrinsic polytypism of tantalum dichalcogenides has emerged as a platform to generate clean and controllable material interfaces. Here, we report on the Fermi surface of 4Hb-TaSe2, a polytype which consists of alternately stacked layers with octahedral (T) and trigonal prismatic (H) coordination of tantalum in the Se-Ta-Se layers. The material is known to host a charge density wave (CDW) phase with star clusters in the T-layers, intercalated by metallic H-layers, but its momentum resolved electronic structure remains undetermined. Using selective area angle resolved photoemission spectroscopy on the T termination combined with ab initio calculations, we unveil a finely structured Fermi surface arising from band folding in the reconstructed Brillouin zone caused by the CDW star clusters. The star-shaped Fermi surface is rotated away from the high-symmetry directions of the normal phase, and exhibits pseudochirality. Theoretical analysis supports the metallic nature of the system and interlayer interactions leading to hybridization. The work provides a detailed overview on the impact of band hybridization with the CDW on the Fermi surface of a material for new phases of quantum matter.
The long journey towards a shift to rail in the European long-distance passenger transport market
Authors: Cats Oded 
Published: February 2025

Abstract
The European long-distance passenger transport market is rapidly changing. There is a striking discrepancy between the relevance of long-distance travel for emission reduction goals and the lack of knowledge to support its design, planning and policy making. A conceptual representation of this market is provided, and four key scientific challenges are identified and discussed along with a brief review of the state-of-the-art, related knowledge gaps and a corresponding research agenda.
Methodological Stimulus Considerations for Auditory Emotion Recognition Test Design
Authors: Morgan Shae D. , LaPaugh Bailey 
Published: February 2025

Purpose:
Many studies have investigated test design influences (e.g., number of stimuli, open- vs. closed-set tasks) on word recognition ability, but the impact that stimuli selection has on auditory emotion recognition has not been explored. This study assessed the impact of some stimulus parameters and test design methodologies on emotion recognition performance to optimize stimuli to use for auditory emotion recognition testing.

Method:
Twenty-five young adult participants with normal or near-normal hearing completed four tasks evaluating methodological parameters that may affect emotion recognition performance. The four conditions assessed (a) word stimuli versus sentence stimuli, (b) the total number of stimuli and number of stimuli per emotion category, (c) the number of talkers, and (d) the number of emotion categories.

Results:
Sentence stimuli yielded higher emotion recognition performance and increased performance variability compared to word stimuli. Recognition performance was independent of the number of stimuli per category, the number of talkers, and the number of emotion categories. Task duration expectedly increased with the total number of stimuli. A test of auditory emotion recognition that combined these design methodologies yielded high performance with low variability for listeners with normal hearing.

Conclusions:
Stimulus selection influences performance and test reliability for auditory emotion recognition. Researchers should consider these influences when designing future tests of auditory emotion recognition to ensure tests are able to accomplish the study's aims.

Supplemental Material:

https://doi.org/10.23641/asha.28270943
Thrombosis at Unusual Sites: Focus on Myeloproliferative Neoplasms and Paroxysmal Nocturnal Hemoglobinuria
Authors: Koschmieder Steffen , Panse Jens 
Published: February 2025

AbstractPatients with thrombosis at an unusual site will need to be explored for rare causes of thrombosis. Two of these rare causes include myeloproliferative neoplasms (MPNs) and paroxysmal nocturnal hemoglobinuria (PNH). It is important not to overlook these causes, since they require specific management, in addition to antithrombotic treatment (anticoagulants, antiplatelet agents). Unusual sites of venous thrombosis include upper extremity veins, splanchnic veins, cerebral veins, and retinal veins, and unusual sites of arterial thrombosis include renal, adrenal, splenic and mesenteric arteries, and intracardiac and aortal locations. Suspicion for MPN and PNH should be raised if there are concomitant abnormalities, such as elevated or decreased blood cell counts or splenomegaly. Diagnosis of MPN and PNH should include JAK2V617F mutational screening as well as flow cytometric assessment of GPI-anchored proteins in the peripheral blood, respectively. Specific treatments for MPN may include phlebotomy or cytoreductive drugs such as hydroxyurea, anagrelide, pegylated interferon-alpha, or Janus kinase inhibitors. Drugs used for PNH treatment include terminal complement inhibitors, such as eculizumab and ravulizumab, as well as proximally acting inhibitors such as pegcetacoplan or iptacopan. Patients with MPN and PNH are at high risk for thrombosis during their entire lifetime and should thus be followed by specialists experienced in the care of these diseases.
Clinical Outcome of Superselective Transarterial Embolization for Acute Colonic Gastrointestinal Bleeding: A Retrospective Single-Center Experience
Authors: Behera Rajendra Kumar , Narang Mohak , Pandey Shivam , Madhusudhan Kumble Seetharama 
Published: February 2025

Abstract
Objective The aim of the study was to assess the safety and efficacy of transarterial embolization in the treatment of acute lower gastrointestinal hemorrhage (LGIH) from colonic origin and to determine factors that influence the treatment outcome.
Methods This retrospective study included 32 patients (mean age: 37.5 years; 24 males) of acute LGIH with a colonic source diagnosed on conventional angiography between March 2014 and May 2023. The clinical characteristics at presentation, laboratory findings, etiology of bleeding, angiographic findings, and embolization details were assessed and correlated with outcomes comprising success rates of embolization, complications, recurrence (immediate and late), and mortality.
Results Embolization was technically successful in 27 patients (84.4%) and clinically successful in 24 patients (75%). Embolic agents used were coils (n = 12), n-butyl cyanoacrylate glue (n = 8), Gelfoam (n = 4), polyvinyl alcohol (PVA) particles (n = 2), and a combination of coils and glue (n = 1). Major complications were seen in five patients (15.6%) including artery dissection (n = 3) and catheter impaction and fracture (n = 2). Sixteen patients (50%) died after a mean period of 8.3 ± 8.8 days mostly due to septic shock related to the underlying cause. Immediate recurrence was observed in five patients (15.6%) after 3.8 ± 1.6 days of embolization and late recurrence in one patient (3.1%) after 76 days. Both univariate and multivariate analyses showed that acute pancreatitis as etiology was significantly associated with mortality (p < 0.05). No other parameters showed any significant association with outcomes.
Conclusion Transarterial embolization is safe and effective in the treatment of acute LGIH due to a colonic source. The etiology of acute pancreatitis is significantly associated with increased mortality.