bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design for Disassembly and Reuse of Timber in Construction: Identification of Trends and Knowledge Gaps
Authors: Passarelli Rafael Novais 
Published: December 2023

AbstractThe transition to a circular economy (CE) offers an alternative path to the current linear, high-polluting, and wasteful practices in construction. In this context, there is a growing interest in studying the potential environmental benefits of extending the lifespan of renewably-sourced wood-based building products through reuse. However, most publications still fail to present a conceptually integrated and comprehensive view of the topic that allows for a broader understanding of its possibilities and challenges. This paper assesses two decades of literature on DfD&R of timber in construction. It develops a comprehensive state-of-the-art framework about the topic, unveiling its most critical challenges, trends, and pressing knowledge gaps. The outcomes of this work contribute to determining more integrated strategies and decision-making tools that could point to further development in the field of timber construction from a DfD&R standpoint, thus facilitating the transition to a CE.
Cosmological quantum states of de Sitter-Schwarzschild are static patch partition functions
Authors: Blacker Matthew J. , Hartnoll Sean A. 
Published: December 2023

Abstract
We solve the Wheeler-DeWitt equation in the ‘cosmological interior’ (the past causal diamond of future infinity) of four dimensional dS-Schwarzschild spacetimes. Within minisuperspace there is a basis of solutions labelled by a constant c, conjugate to the mass of the black hole. We propose that these solutions are in correspondence with partition functions of a dual quantum mechanical theory where c plays the role of time. The quantum mechanical theory lives on worldtubes in the ‘static patch’ of dS-Schwarzschild, and the partition function is obtained by evolving the corresponding Wheeler-DeWitt wavefunction through the cosmological horizon, where a metric component gtt changes sign. We establish that the dual theory admits a symmetry algebra given by a central extension of the Poincaré algebra $$ \mathfrak{e} $$
e
(1, 1) and that the entropy of the dS black hole is encoded as an averaging of the dual partition function over the background gtt.
Threshold factorization of the Drell-Yan quark-gluon channel and two-loop soft function at next-to-leading power
Authors: Broggio Alessandro , Jaskiewicz Sebastian , Vernazza Leonardo 
Published: December 2023

Abstract
We present a factorization theorem of the partonic Drell-Yan off-diagonal processes $$ g\overline{q}(qg)\to {\gamma}^{\ast }+X $$
g

q
¯

qg

→

γ
∗

+
X
in the kinematic threshold regime $$ z={Q}^2/\hat{s}\to 1 $$
z
=

Q
2

/

s
̂

→
1
at general subleading powers in the (1 − z) expansion. Focusing on the first order of the expansion (next-to-leading power accuracy with respect to the leading power $$ q\overline{q} $$
q

q
¯

channel), we validate the bare factorization formula up to $$ \mathcal{O}\left({\alpha}_s^2\right) $$
O

α
s
2

. This is achieved by carrying out an explicit calculation of the generalized soft function in d-dimensions using the reduction to master integrals and the differential equations method. The collinear function is a universal object which we compute from an operator matching equation at one-loop level. Next, we integrate the soft and collinear functions over the convolution variables and remove the remaining initial state collinear singularities through PDF renormalization. The resulting expression agrees with the known cross section in the literature.
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Authors: Medina-Cáliz Inmaculada , Sanabria-Cabrera Judith , Villanueva-Paz Marina , Aukštikalnė Lauryna , Stephens Camilla , Robles-Díaz Mercedes , Pinazo-Bandera José M. , García-Cortes Miren , Conde Isabel , Soriano German , Bessone Fernando , Hernandez Nelia , Nunes Vinicius , Paraná Raymundo , Lucena M. Isabel , Andrade Raúl J. , Niu Hao , Alvarez-Alvarez Ismael 
Published: December 2023

AbstractIdiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess the clinical characteristics, outcomes, and causative agents in a prospective, well-vetted cohort of DILI patients with DRESS (DILI-DRESS). We identified 53 DILI-DRESS cases from the Spanish DILI Registry and the Latin American DILI Network. For comparison purposes, we defined a group of DILI patients (n = 881). DILI-DRESS cases were younger (47 vs. 53 years, respectively; p = 0.042) and presented more frequently with cholestatic/mixed damage (p = 0.018). Most DILI-DRESS patients showed moderate liver injury, 13% developed severe damage, and only one patient (with hepatocellular injury due to anti-tuberculosis drugs) progressed to acute liver failure and died. DILI-DRESS cases showed a distinctive causative drug pattern compared to DILI cases. The most frequent drugs were carbamazepine (13%), anti-tuberculosis drugs (13%), amoxicillin-clavulanate (11%), and allopurinol and lamotrigine (7.6% each). Among all cases of DILI due to allopurinol and lamotrigine, 67% presented with a DILI-DRESS phenotype, respectively. Higher total bilirubin (TBL) levels at DILI recognition (odds ratio [OR] 1.23; 95% confidence interval [CI] 1.04–1.45) and absence of eosinophilia (OR 8.77; 95% CI 1.11–69.20) increased the risk for developing a severe-fatal injury in DILI-DRESS patients. DILI-DRESS patients have a more frequent cholestasis/mixed pattern of injury at presentation, with antiepileptics as distinctive causative drug class. Most of the lamotrigine and allopurinol cases present with this phenotype. Higher TBL levels and absence of eosinophilia at DILI recognition are markers of poor outcomes.
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Authors: Franzin Martina , Ruoso Rachele , Peruch Michela , Stocco Gabriele , D’Errico Stefano , Addobbati Riccardo 
Published: December 2023

AbstractSudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in children, and toxicological testing would help identify the cause of the death. Analytical methods sensitive and specific for the quantification of a great number of drugs and metabolites in at least 2 matrices should be used. Bile, collected postmortem, may be considered a specimen alternative to blood and urine to perform toxicological testing because of its extended detection window. The present study proposed a LC–MS/MS method to quantify 108 drugs and metabolites in bile. Compounds belonging to the drugs of abuse classes of amphetamines, benzodiazepines, cocaine derivatives, barbiturates, opioids, z-drugs, and psychedelics were analyzed. The sample preparation is simple and does not require solid-phase extraction. The proposed method showed an appropriate selectivity, specificity, accuracy, and precision of the calibrators and quality controls tested (precision < 15%; accuracy < 100 ± 15%). The sensitivity allowed to identify low amounts of drugs (e.g., morphine limit of detection = 0.2 µg/L; limit of quantification = 1.1 µg/L). There is no significant matrix effect, except for buprenorphine and 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol. Carry-over was not present. Analytes were stable at least for 1 month at − 20 °C. Analyzing 13 postmortem specimens, methadone (50%), and cocaine (37.5%) resulted to be the most prevalent consumed substances; the concentrations quantified in bile resulted to be higher than the ones in blood suggesting bile as a potential new matrix for identifying illicit drugs and their metabolites.
Genetic, Immunological, Dietary, Gut Microbiota, and Environmental Determinants of Osteoporosis in the Course of Celiac Disease: Which Factor Plays the First Violin in This Orchestra?
Authors: Skoracka Kinga , Hryhorowicz Szymon , Tovoli Francesco , Raiteri Alberto , Rychter Anna Maria , Słomski Ryszard , Dobrowolska Agnieszka , Granito Alessandro , Krela-Kaźmierczak Iwona 
Published: December 2023

AbstractCeliac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The worldwide prevalence of CD is estimated to be 0.7–1.4% of the general population. Etiopathology of this disease is multifactorial, with genetic determinants being a major contributing player to CD susceptibility. Its manifestation embraces different organs, including the musculoskeletal apparat. Patients with CD have increased risk of bone disorders. According to data, bone disorders – osteopenia and osteoporosis – can affect up to 70% of patients with CD at diagnosis, and it decreases after the initiation of a gluten-free diet. Gluten consumption in patients with CD triggers an inflammatory reaction followed by tissue damage, and both; local and systemic inflammation can increase the risk of bone mass deterioration. Other theory assumes shortages of vitamin D and an impaired calcium absorption mechanism leading to secondary hyperparathyroidism. Taking into account the increasing prevalence of CD and osteoporosis, we broadly discuss genetic, immunological, dietary, gut microbiota, and environmental factors that could increase the risk of osteoporosis in CD. Furthermore, we discuss lifestyle and pharmacological preventing and treatment measures.
Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner
Authors: Rubinski Anna , Dewenter Anna , Zheng Lukai , Franzmeier Nicolai , Stephenson Henry , Deming Yuetiva , Duering Marco , Gesierich Benno , Denecke Jannis , Pham An-Vi , Bendlin Barbara , Ewers Michael ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: December 2023

Abstract
Purpose
The main objectives were to test whether (1) a decrease in myelin is associated with enhanced rate of fibrillar tau accumulation and cognitive decline in Alzheimer’s disease, and (2) whether apolipoprotein E (APOE) ε4 genotype is associated with worse myelin decrease and thus tau accumulation.

Methods
To address our objectives, we repurposed florbetapir-PET as a marker of myelin in the white matter (WM) based on previous validation studies showing that beta-amyloid (Aβ) PET tracers bind to WM myelin. We assessed 43 Aβ-biomarker negative (Aβ−) cognitively normal participants and 108 Aβ+ participants within the AD spectrum with florbetapir-PET at baseline and longitudinal flortaucipir-PET as a measure of fibrillar tau (tau-PET) over ~ 2 years. In linear regression analyses, we tested florbetapir-PET in the whole WM and major fiber tracts as predictors of tau-PET accumulation in a priori defined regions of interest (ROIs) and fiber-tract projection areas. In mediation analyses we tested whether tau-PET accumulation mediates the effect of florbetapir-PET in the whole WM on cognition. Finally, we assessed the role of myelin alteration on the association between APOE and tau-PET accumulation.

Results
Lower florbetapir-PET in the whole WM or at a given fiber tract was predictive of faster tau-PET accumulation in Braak stages or the connected grey matter areas in Aβ+ participants. Faster tau-PET accumulation in higher cortical brain areas mediated the association between a decrease in florbetapir-PET in the WM and a faster rate of decline in global cognition and episodic memory. APOE ε4 genotype was associated with a worse decrease in the whole WM florbetapir-PET and thus enhanced tau-PET accumulation.

Conclusion
Myelin alterations are associated in an APOE ε4 dependent manner with faster tau progression and cognitive decline, and may therefore play a role in the etiology of AD.
Biochemical Characterization of Thermostable Acrylamide Amidohydrolase from Aspergillus fumigatus with Potential Activity for Acrylamide Degradation in Various Food Products
Authors: El-Sayed Ashraf S. A. , Elghamry Hala N. , Yassin Marwa A. 
Published: December 2023

AbstractAcrylamide is the major by-product of the Maillard reactions in foods with the overheating processes of L-asparagine-rich foods with reducing sugars that usually allied with neurotoxicity and carcinogenicity. Several approaches have been used to prevent the formation of acrylamide, however, degrading the already formed acrylamide in foods remains unequivocal. Acrylamide hydrolyzing enzyme “amidohydrolase” is one of the most promising enzymes for acrylamide degradation in foods. So, amidohydrolase “amidase” from thermotolerant Aspergillus fumigatus EFBL was purified to their electrophoretic homogeneity by gel-filtration and ion-exchange chromatography, with overall purification folds 2.8 and yield 9.43%. The apparent molecular subunit structure of the purified A. fumigatus amidase was 50 kDa, with highest activity at reaction temperature of 40 °C and pH of 7.5 The enzyme displayed a significant thermal stability as revealed from the value of T1/2 (13.37 h), and thermal denaturation rate (Kr 0.832 × 10–3 min) at 50 °C, with metalloproteinic identity. The purified enzyme had a significant activity for acrylamide degradation in various food products such as meat, cookies, potato chips, and bread as revealed from the HPLC analysis and LC–MS analysis. So, with the purified amidase, the acrylamide in the food products was degraded by about 95% to acrylic acid, ensuring the possibility of using this enzyme in abolishing the toxic acrylamide in the foods products. This is the first report exploring the potency of A. fumigatus amidase for an actual degradation of acrylamide in foods efficiently. Further biochemical analyses are ongoing to assess the affinity of this enzyme for selective hydrolyses of acrylamide in foods, without affecting the beneficial stereochemical related compounds.
Endometriosis: patient–doctor communication and psychological counselling
Authors: Wischmann Tewes , Ditzen Beate 
Published: December 2023

AbstractThe fact that endometriosis is one of the most frequent gynaecological disorders in women and girls is gradually attracting greater public and political attention. There is also substantial awareness of the disorder among German gynaecologists, albeit without sufficient “equipment” for discussing the condition with patients and providing psychological counselling. This article offers hands-on proposals for medical counselling and the discussion of relevant issues, as well as other practical tips and suggested verbalisations for use by women suffering from endometriosis (and their partners). These practical recommendations will certainly help to improve the doctor–patient relationship in the case of endometriosis. The resources mentioned below (guidebooks, websites) focus on German-language offerings only.
Responses of the Pacific and Atlantic decadal variabilities under global warming by using CMIP6 models
Authors: Shang Yuyang , Liu Peng , Wu Sheng 
Published: December 2023

AbstractDecadal variability in the ocean is an important indicator of climate system shifts and has considerable influences on marine ecosystems. We investigate the responses of decadal variability over the global ocean regions using nine CMIP6 models (BCC-CSM2-MR, CESM2-WACCM, CMCC-ESM2, EC-Earth3-Veg-LR, FGOAL-f3-L, INM-CM5-0, MIROC6, MPI-ESM1-2-LR, and NorESM2-MM). Our results show that climate models can capture the Pacific Decadal Oscillation, Tropical Pacific Decadal Variability, South Pacific Decadal Oscillation, and Atlantic Multidecadal Variability under present-day conditions. The ocean decadal variabilities are becoming weaker and their periods are decreasing, especially under the strong global warming scenario. However, there is a discrepancy between the Tropical Pacific Decadal Variability and the other three modes of climate variability. This might be caused by the nearly unchanged atmospheric forcing in the equatorial region, which is decreasing in the higher latitude regions.
Automatic correction of barometric altimeters using additional air temperature and humidity measurements
Authors: Matyja Tomasz , Stanik Zbigniew , Kubik Andrzej 
Published: December 2023

AbstractA GPS module is often combined with an atmospheric pressure sensor in onboard navigation systems. Thanks to this, using appropriate algorithms comparing the results obtained from GPS and from the barometric altimeter, it is possible to obtain much more accurate indications of the height above sea level. The authors analyzed the problem of correcting barometric altimeter errors caused by non-standard pressure and temperature conditions at sea level and the presence of water vapor in the air. The authors proposed methods of correcting the altimeter error using additional temperature and air humidity measurements. They also proposed a simple method for calibrating the altimeter prior to the mission to estimate the difference in pressure above the standard value. The paper discusses the influence of water vapor on the accuracy of the altimeter indications and the conditions for the applicability of the error correction method. The authors initially considered the possibility of using the method based on the concept of virtual temperature. However, this method was rejected because simulation studies showed that it did not give satisfactory results. Simulation tests were carried out in the MATLAB environment to assess the effectiveness of the proposed methods. The test results turned out to be satisfactory. They can be useful when designing low-cost navigation systems using simple sensors made in MEMS technology. The main envisaged application is in autonomous drone navigation systems.
South Korea and the EU battling COVID-19: shared contribution to global health governance and human security
Authors: Novotná Tereza , Kim Nam Kook 
Published: December 2023

AbstractCommemorating the 60th anniversary of diplomatic ties, the article analyzes public health governance during the COVID-19 pandemic in the EU and South Korea. Shifting focus from traditional national security to a more people-centered understanding, the article employs the human security framework to examine nuances of the global health crisis. Through this theoretical lens, the research empirically compares and contrasts the EU’s and South Korea’s differing strategies battling COVID-19 from the pandemic’s inception to the mass vaccination rollouts. While the EU’s early approach was initially marked by slower responsiveness and border closures, South Korea stood out for its swift counter-epidemic measures, leveraging technological innovations and public–private partnerships. Yet once vaccination campaigns started, South Korea had to catch up with Europe. The article chronologically presents its findings, identifying a mutual convergence in approaches with the Omicron’s emergence. In conclusion, the article distills seven key lessons from the pandemic management: the significance of independent public health institutions, the role of digitalization and transparency in fostering public trust, the shared responsibility to bridge the vaccination gap and invest in robust public health systems, and the paradigm shift towards human security combined with the resurgence of state which has to be balanced with safeguarding individual liberties and a collective global action. In addition, the article underscores potential avenues for a strengthened EU-South Korea collaboration to enhance global health governance beyond the confines of major geopolitical rivalries.
Predator-friendly ranching, use of electric fences, and creole cattle in the Colombian savannas
Authors: Valderrama-Vasquez Carlos , Hoogesteijn Rafael , Payán Esteban , Quigley Howard , Hoogesteijn Almira 
Published: December 2023

AbstractLivestock ranching overlaps extensively with jaguar and puma distribution in the Casanare Department of east-central Colombia. Conservation programs prioritize large carnivores in the region. Ranchers retaliate by killing them in response to economic losses or fear related to their presence. Reducing retaliatory hunting is a top priority in the conservation of feline species. Predation mitigation methods (PMMs) are necessary to reduce depredation and increase tolerance for large felines. In a prospective cohort study, 16 ranches between 2017 and 2019 used electric fences (n = 14) and introduced creole cattle (n = 2) as PMMs. There was a significant difference in the risk and odds ratios between the control and treatment groups. Livestock depredation was 14.78 times higher outside PMM areas (OR, 14.78; RR, 0.069; p < 0.001) than inside such areas. The losses caused by depredation were much higher than the investments made in PMMs.
Toward a certified greedy Loewner framework with minimal sampling
Authors: Pradovera Davide 
Published: December 2023

AbstractWe propose a strategy for greedy sampling in the context of non-intrusive interpolation-based surrogate modeling for frequency-domain problems. We rely on a non-intrusive and cheap error indicator to drive the adaptive selection of the high-fidelity samples on which the surrogate is based. We develop a theoretical framework to support our proposed indicator. We also present several practical approaches for the termination criterion that is used to end the greedy sampling iterations. To showcase our greedy strategy, we numerically test it in combination with the well-known Loewner framework. To this effect, we consider several benchmarks, highlighting the effectiveness of our adaptive approach in approximating the transfer function of complex systems from a few samples.
An Alternative Foundation of Quantum Theory
Authors: Helland Inge S. 
Published: December 2023

AbstractA new approach to quantum theory is proposed in this paper. The basis is taken to be theoretical variables, variables that may be accessible or inaccessible, i.e., it may be possible or impossible for an observer to assign arbitrarily sharp numerical values to them. In an epistemic process, the accessible variables are just ideal observations connected to an observer or to some communicating observers. Group actions are defined on these variables, and group representation theory is the basis for developing the Hilbert space formalism here. Operators corresponding to accessible theoretical variables are derived, and in the discrete case, it is proved that the possible physical values are the eigenvalues of these operators. The focus of the paper is some mathematical theorems paving the ground for the proposed foundation of quantum theory. It is shown here that the groups and transformations needed in this approach can be constructed explicitly in the case where the accessible variables are finite-dimensional. This simplifies the theory considerably: To reproduce the Hilbert space formulation, it is enough to assume the existence of two complementary variables. The interpretation inferred from the proposed foundation here may be called a general epistemic interpretation of quantum theory. A special case of this interpretation is QBism; it also has a relationship to several other interpretations.