bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryoablation of the Sacroiliac Joint in a Case of Sacroiliac Joint Arthropathy
Authors: Chilumula Ch Pavani , Das Gautam , Kara Krishna Ramesh 
Published: January 2025

Abstract
Sacroiliac joint (SIJ) is one of the most common but underdiagnosed sources of lower back pain, with the prevalence of 15%–30%. Treatments of SIJ pain most commonly involve conservative strategies that are exercises or medications. Various methods for nonresponders of SIJ pain are local anesthetic with or without steroid injection, radiofrequency denervation of SIJ with either conventional, cooled, or cryoablation technique. As SIJ has complex sensory innervation and cryoablation has an added benefit of larger size lesion and immediately pain relief can be tried for better results. Hence, here, we present a patient who had a complaint of SIJ pain and undergone cryoablation with hybrid technique using ultrasonography and fluoroscopy.
Usage of Triphala choornam, Padigara neer, Nilavembu kudineer, and Maththan thylam in treating Pitha Iyya Madhumega Punn in Siddha: A case series study
Authors: Gangadharan Binthuja , Nelson Reuben Kingseeli Devadass 
Published: January 2025

Abstract

Background:

Pitha Iyya Madhumega pun, also known as diabetic ulcers, are a major concern for individuals with high blood sugar levels. These ulcers have a slow healing rate and are at risk of recurrence and also referred to as “Arithir theervana,” indicating their slow or non-healing nature. However, with proper care and treatment following the Siddha regimen, diabetic ulcers can be effectively treated.

Case Series:
A 65-year-old man (case 1), a 67-year-old man (case 2), a 63-year-old woman (case 3), and a 57-year-old man (case 4) presented to the Government Primary Health Centre, Siddha Wing, Kayamozhi, Tuticorin, with complaints of whitish pus leakage, pain, and swelling around wounds. They were diagnosed with diabetic ulcers and treated externally with Siddha medications including Thiriphala chooranam, Padigara neer, Nilavembu kudineer (Siddha formulation), and Maththan thylam (wound-healing Siddha medicated oil) to document wound-healing efficacy.

Conclusion:
Reduction in the pus formation along with faster wound healing was observed when Padigara neer was used as Kazhuvu Neer (washing solution), Nilavembu kudineer as Vedhu (steaming), and Maththan thylam dressing. The ulcer was healed completely, and the patient’s daily functioning showed improvement. The Siddha treatment has shown promising results in managing diabetic ulcers, as demonstrated in this study; further randomized controlled trials are necessary to validate these findings.
The role of single dose and prolonged antibiotic prophylaxis in the presence of drains to prevent surgical site infections: A systematic review and meta-analysis of randomized controlled trials
Authors: Wang Jiajie , Chi Jiayu , Wu Meilin , Wu Wenqi , Zhou Zhitao , Xu Li , Qiu Mingjie , Tian Sai , Dou Liuqing , Wu Xiuwen , Ren Jianan 
Published: January 2025

Introduction:
The duration of antibiotic use in patients with postoperative drains is a critical aspect of postsurgical care aimed at preventing surgical site infection (SSI) and reducing adverse events. Therefore, we conducted this meta-analysis to assess the efficacy and safety of prolonged antibiotic prophylaxis in the presence of postoperative drainage to prevent SSIs.

Methods:
A comprehensive search in MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, World Health Organization regional medical databases, and African Index Medicus was performed. The time limit was set from January 1990 to June 2024. The quality of the evidence from the studies was further assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. The study protocol was registered previously on PROSPERO (ID: CRD42024516856).

Results:
Twelve randomized controlled trials concerning whether to prolong the use of prophylactic antibiotics were enrolled finally and recruited a total of 3692 patients, with 1837 in the prolonged group and 1855 in the single-dose group. Meta-analysis of the data pooled from the 12 studies showed no difference in risk of SSI between the two groups (odds ratio: 0.90; 95% confidence interval: [0.72–1.13]; P = 0.36). No publication bias was found. According to the GRADE, the quality of evidence was low due to serious risk and serious imprecision.

Conclusion:
The meta-analysis shows that prolonged antibiotic prophylaxis in the presence of a wound drain has neither benefit nor harm in reducing SSI. Single-dose antibiotic prophylaxis in the presence of drainage would be feasible in any setting.
Comprehensive analysis of indole-2-carboxylic acid as an antioxidant drug: Spectroscopic, quantum chemical, topological and molecular docking studies
Authors: S. Jeba Reeda V. , N. Cheerlin Mishma J. , Divyab, Nazrul Haq P. , Muthu S. , Siddiqui Nazia , Javed Saleem 
Published: January 2025

Bioactive indole-derived compounds have become increasingly important in current years owing to their wide range of biological and pharmacological uses. In this work, vibrational, electrical, physicochemical, and suppressive attributes of Indole-2-carboxylic acid (ID2CA) are predicted and analyzed. First, the molecular structure of ID2CA was refined, and its structural characteristics were computed in different environments, including polar solvents (DMSO, methanol, and water) as well as in the gas phase. A strong correlation was observed between the molecule's simulated and experimentally obtained infrared spectra. Measured UV-Visible spectra confirm the ID2CA's π→π* electronic shift, which is compatible with the computed spectra. Subsequent examination of FMO revealed intramolecular charge transfer (CT) throughout the molecule, highlighting ID2CA's bioactivity. To verify findings of the natural charge assessment and FMOs, Fukui function values were computed. ID2CA was discovered to be a significant part of the antioxidant resistance system by molecular docking studies. After performing 100 ns MD simulations and effective free energy computations with MMPBSA, durability of the best-docked protein (2C9V) was evaluated.
Bull. Chem. Soc. Ethiop. 2025, 39(4), 763-780.
DOI: https://dx.doi.org/10.4314/bcse.v39i4.12
Derivative spectrophotometric determination of quinine, adenine and metoclopramide hydrochloride in their binary mixture using zero–crossing technique
Authors: H. Naggar Ahmed , Alfarsi Anas , A. Farghaly Othman , A. Taher Mahmoud , El–Aziz Y. El–Sayed Abd , A. Abdelwahab Adel 
Published: January 2025

A first–derivative spectrophotometric procedure has been applied for the simultaneous quantification of quinine–adenine or quinine–metoclopramide hydrochloride in their mixes using “zero–crossing” measuring approach. The first–derivative spectra of quinine and adenine allowed the determination of quinine (1.5–17.9 µg/mL) in the presence of 4.3 µg/mL of adenine, and adenine (5.4–27.0 µg/mL) in presence of 9.0 µg/mL of quinine. In the binary mixture of quinine–metoclopramide hydrochloride, the first–derivative spectra of quinine and metoclopramide hydrochloride allowed the determination of quinine (11.95–95.62 µg/mL) in presence of 5.4 µg/mL of metoclopramide hydrochloride, and metoclopramide hydrochloride (1.34–21.52 µg/mL) in existence of 29.88 µg/mL of quinine. A statistical scrutiny of the provided practical data was used to perform a critical assessment of the recommended approaches.
Bull. Chem. Soc. Ethiop. 2025, 39(4), 615-628.
DOI: https://dx.doi.org/10.4314/bcse.v39i4.2
Synthesis of a hybrid nanomaterial combining silver nanoparticles with water-soluble zinc phthalocyanines [ZnPc(CO2H)4(COATP)4@AgNPs]
Authors: Tarpaga Lassané , Bakouan Youssoufou , Ouédraogo Seydou , Sessouma Bintou , Bayo-Bangoura Mabinty , Amiens Catherine , Esvan Jérôme , Bayo Karifa 
Published: January 2025

Phthalocyanine based hybrid nanomaterials show promises in biomedical applications. However, their lack of solubility in aqueous phase limits their development. This paper aims at bringing some answers to this problem, by reporting the synthesis of a hybrid nanomaterial consisting of new zinc phthalocyanines substituted with four carboxylic acid functions and four thiol functions, [ZnPc(CO2H)4(COATP)4@AgNPs], associated with silver nanoparticles (AgNPs). The isolated hybrid species were characterized by UV-Visible, infrared (IR) and Raman spectroscopy, inductively coupled plasma atomic emission spectrometry (ICP-AES), powder X-ray diffraction (XRD), X-ray photoelectron spectrometry (XPS) and transmission electron microscopy (TEM). They show that the hybrid species consists in circa 20 nm large AgNPs with a characteristic absorption band that undergoes a bathochromic effect of about 30 nm in comparison to the parent AgNPs, in agreement with a functionalization of their surface. The XPS results give tangible proof of the establishment of an Ag-S bond, indicative of the coordination of the zinc phthalocyanine complexes to the AgNP surface via their peripheral thiol functions. With their four peripheral carboxylic acid functions, the zinc phthalocyanine complexes grafted on the AgNPs should impart a significant solubility to the hybrid system thus allowing its use in the biomedical field.
Bull. Chem. Soc. Ethiop. 2025, 39(4), 713-729.
DOI: https://dx.doi.org/10.4314/bcse.v39i4.9
Radiometric assessment of the sewage treatment site at Ahmadu Bello University, Zaria
Authors: Umar M. , Ahmed Z. , Vatsa A.M. , Balarabe B. , Saad A.A. 
Published: January 2025

The radiometric assessment of Ahmadu Bello University's sewage treatment site in Zaria was conducted in three profiles along two ponds in the research region. The goal is to estimate the concentration and dose rate of naturally occurring radioactive elements, as well as to assess the risk to workers in the area. Gamma-ray spectrometer alongside with GPS (global positioning system) were used. The concentration of 238U, 232Th and 40K were contour to show the areas of high concentration of the radionuclide. The data were taken at 5 m interval in each profile along the sewage ponds. The data collected were interpreted using the golden software surfer 16. The concentration of the radionuclide 238U, 232Th and 40K in the study area were found to be between the range of 2 ppm - 21 ppm which is equivalent to the activity levels of 22.2 Bq/kg - 233.1 Bq/kg for 238U, 14.5 232 ppm - 29.5 ppm which is equivalent to the activity levels of 58.87 Bq/kg - 119.77 Bq/kg for 232Th and 2.5% - 40 10.5% which is equivalent to the activity levels of 782.5 Bq/kg - 3286.5 Bq/kg for 40K respectively. The dose rate of the radionuclide U, 232Th and 40K in the study area were 11.35 nGy/h - 119.18 nGy/h for 238U, 36.16 nGy/h - 73.57nGy/h for 232Th and 32.69 nGy/h - 137.29 nGy/h for K respectively. The total count and absorb dose spanned within the range of 330 - 395 cps and 115 - 200 nGy/h respectively. The result show that the absorbed dose rate of the radionuclide ( 238U, 232Th and 40K) and total absorbed dose rate are above world average.
Assessment of soil transmitted helminths in soil ready for primary school farming activity in Omelema
Authors: Ekine E.G , Orluoma C.A. 
Published: January 2025

Approximately every rural inhabitant in Nigeria is at risk of diseases transmissible by helminthes worms also known as soil transmitted helminthes. This study evaluates the level soil transmitted helminths contamination level of soil prepared for school farming activity in Omelema. A total of 50 soil samples were collected and analyzed for soil transmitted helminths contamination using the formalin ether sedimentation technique and saturated salt floatation methods. Thirty one samples representing 62.0% were contaminated with soil transmitted helminths. The soil transmitted helminths implicated in this study are Strongyloies (45.6 %), Ascaris (36.9 %) and hook worm species (17.5 %). The presence of soil transmitted helminths in this study called for serious concern in the public health sector and demand that the rural inhabitants be adequately oriented on preventive strategies to avert prospect infection threat. The scenario in this survey suggests that prohibition of open defecation alongside personal cleanliness in private and public places if taken seriously can mitigate infections of soil transmitted helminths in every locality.
Bioremediation and growth promoting effects of identified bacteria from different soil locations in Nigeria
Authors: Momoh-Salami T.M. , Akinyemi N.M. , Ajiboye G.A. , Oyetibo G.O. , Adams L.A. , Ogunkanmi L.A. , Ilori M.O. 
Published: January 2025

Soil contains diverse bacteria that are vital for maintaining soil health and fertility. While many soil bacteria are known for their plant growth-promoting (PGP) abilities, combining this role with bioremediation is less common. The ability of the bacteria isolates to solubilize phosphate, fix nitrogen and bioremediate environmental pollutants were investigated in this study. Isolated organisms were further tested to know their ability to sequester toxicants such as heavy metals, pesticides and hydrocarbons while their capability to produce growth hormones were also confirmed. The bacteria were molecularly identified using the 16S rDNA sequencing. The identified isolates were: Bacillus species, Enterobacter species and Vagococcus fluvialis. Production of halo zones on the Pikovskaya's agar showed the proficiency of the organisms to solubilize phosphate, change of Salkowiski's reagent to pink displayed their ability to produce Indole acetic acid while their capability to produce siderophore was indicated by the change in the dark blue CAS indicator to orange. The heavy metal tolerance test conducted showed that the organisms could resist metals at maximum concentration of: chromium (1.0mM), lead (16.0mM), cadmium (1.6mM) and nickel (4.0mM). All the bacteria isolated and identified were found to have great biofertilizer potential. At the same time, they also serve as bioremediators of polluted environment as well as biofertilizers.
Effect of different storage conditions on aflatoxin production in oven-dried tilapia fish (<i>Oreochromis niloticus</i>)
Authors: Feruke-Bello Y.M. , Okeleye B.I. , Adesiyan I.M. , Adesiyan I.M. , Adefioye S.J. , Adefioye S.J. 
Published: January 2025

Aflatoxin produced by Aspergillus species are carcinogenic and pose significant health risks to consumers of contaminated food products.The storage conditions of oven-dried fish play a crucial role in controlling aflatoxin production. This study examined aflatoxin production in oven-dried tilapia fish under different storage conditions. A total of 36 fishes were bought fresh, oven-dried and stored in bamboo baskets and plastic containers. The isolation and Identification of fungi were carried out weekly for 4 weeks and and aflatoxin was detected by high-performance liquid chromatography (HPLC) method. The highest moisure content (%MC) of the oven-dried Tilapia fish were subjected to temperature ranges 80 °C - 130 °C was 76.7% at 130 °C. The total fungal count ranges from 2.65±0.01 to 3.31±0.02 log cfu/g with the highest count recorded in covered bamboo basket while the lowest was from tightly covered storage plastic. Six fungal isolates namely Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, mucor, yeast, and Penicillium chrysogenum were associated with the stored ovendried tilapia fish samples. The oven-dried tilapia fish stored in bamboo baskets (opened and closed); and opened plastic container were contaminated with three (3) Aspergillus sp. and a Penicillium sp. with aflatoxin B1 levels ranging from 0.62 to 0.90 ppb. Remarkably, no fungi or aflatoxin were detected in the tightly covered storage plastics (TCSPs) containing fish that were oven-dried at 130 °C (designated as A) in sharp contrast to bamboo basket-stored fish which exhibited elevated fungal counts. The results obtained from this study highlights the critical function of storage conditions in controlling aflatoxin production in oven-dried tilapia fish. The application of best storage practices can decrease contamination, ensuring safer consumption and reduced health risks.
Effects of leaf blight caused by <i>Colletotrichum</i> and <i>Lasiodiplodia</i> species on the growth and yield parameters of melons (<i>Citrulus</i> and <i>Leganaria</i> species)
Authors: Ogunsola J.F. , Ogunsola K.E. , Ikotun B. 
Published: January 2025

Melons (Citrullus lanatus (Thumb) Mansf. and Leganaria siceraria (Mol.) Standley) are vital vegetable crops in West Africa, valued for their edible nutrient-rich seeds and oil. However, their production is impacted by leaf blight, while the economic yield loss caused by this disease is not well documented. This study examined the effects of three blight-causing pathogens: Colletotrichum truncatum (Ct), Colletotrichum gloeosporioides (Cg), and Lasiodiplodia theobromae (Lt) on the growth and yield traits of melon. Three melon cultivars (Bara, Serewe, and Bojuri) were artificially inoculated with these pathogens in two field trials using a randomized complete block design with four replicates. Data on growth and yield parameters (GYPs) were analyzed using analysis of variance (p<0.05). The pathogens significantly affected GYPs depending on the cultivar. In Serewe cultivar, Lt significantly reduced vine length (from 82.9 to 28.2 cm) and the number of leaves (from 74.3 to 39.2). In Bara, the three pathogens reduced the number of leaves and number of vines, while a significant reduction of vine length was caused by Ct (from 98.2±9.9 to 42.4±7.7cm) and Lt (98.2±9.9 to 41.5±13.6cm). However, the GYPs of Bojuri was unaffected by the three blight pathogens. The pathogens also reduced the number of fruits per/plant of Serewe cultivar (from 7.8±2.6 to 3.1±0.6) and weight of fruits/per plant (from 8.0±5.0 to 1.6±0.9 kg) and all the evaluated yield parameters in Bara except weight of fruits/plant which was only reduced by Ct (from 3.1±0.8 to 1.2±0.8 kg). Lasiodiplodia theobromae (95.7%) and Ct (92.9%) caused the highest reduction observed in the weight of seeds/plant of Serewe and Bara, respectively. This study highlights significant yield losses due to Colletotrichum and Lasiodiplodia species in Serewe and Bara melon cultivars, emphasizing the need for effective disease management strategies.
Evaluation of rodenticidal potential of yellow oleander (<i>Thevetia neriifolia tuss.</i>) seed powder in wild female African giant rat (<i>Cricetomys gambianus W.</i>)
Authors: Badmus H.A. , Fayinminnu O.O. , Adeyanju T.J. 
Published: January 2025

Cricetomys gambianus is a wild rodent species attacking crops. Conventional rodent control is via the use of synthetic rodenticides with health and environmental concerns. Thevetia neriifolia seed reportedly has rodenticidal potential in the laboratory rodents. However, rodenticidal activity of T. neriifolia seed has not been evaluated in wild rodent species. Therefore, this study attempted to evaluate the rodenticidal potential of yellow oleander seed powder in wild C. gambianus. Twenty wild-caught female C. gambianus were acclimatized for 4 weeks in Animal house and randomly allocated into 4 groups including control. The T. neriifolia seed was dried under the shade, blended, and mixed with a commercial feed with 4 different concentrations of the seed powder (0%, 20%, 40%, and 80%) and then turned to pellet. The acclimatized animals were fed with appropriate concentrations of the formulated feed for 8 weeks. Body-Weight and Feed- Intake of the animals were taken. Their behavior before and after introduction of the feed was also recorded. At termination, tissue samples (Kidney, Liver, and Heart) were collected for histopathology analysis. Data were analyzed in SPSS using ANOVA and means separated using DMRT at α . The results showed no significant effect on the animals' mean Body-Weight and Feed- 0.05 Intake (p˃0.05). No mortality and behavioral changes were observed in the animals at all the concentrations. No visible lesions in the kidney, liver, and heart across the treatment groups compared to control. In conclusion, T. neriifolia seed powder did not have rodenticidal effect on the wild female C. gambianus. Therefore, it could not be used as a rodenticide in the management of wild rodent species population.
Effect of colchicine induction on the phenotypic, mineral and phytochemical compositions of <i>Amarantus cruentus L.</i>
Authors: Komolafe R.J. , Akinola J.S. , Alabi S.A. , Oseni M.O. , Oluwajobi A.O. , Chukwuma D.M. 
Published: January 2025

The development of genetically improved crops by breeders to meet the needs of farmers and populace requires the induction of genetic variability in crops to produce unique variants. Colchicine-induced mutagenesis has emerged as a promising technique for generating genetic variations and improving plant characteristics. The study investigated the impact of varying concentrations of colchicine on the phenotypic traits, mineral, and phytochemical compositions of Amaranthus cruentus. The research was conducted at the screen house of the Department of Plant Science and Biotechnology, Federal University Oye-Ekiti, Ekiti State, Nigeria. The seeds of Amaranthus cruentus were planted in plastic bowls with varying concentrations of colchicine (0.1 g/ml, 0.2 g/ml, and 0.3 g/ml) of colchicine, while 0.0 serves as the control and the experiment was set up in triplicates. The subsequent effects on the phenotypic traits, phytochemical and mineral compositions were evaluated at maturity. Phenotypic traits including plant height, leaf size, leaf shape, and inflorescence characteristics were assessed. Phytochemical and mineral compositions of the matured plants were also determined. The results reveal significant variations at p ≤ 0.05 in phenotypic traits among the mutant lines compared to the control group. Changes in growth patterns, and leaf morphology were observed, indicating successful induction of genetic variations through colchicine treatment. The mineral profiles including iron, zinc, calcium, sodium, potassium, manganese and phytochemical compositions such as flavonoids, phenols and tannins of the mutant lines exhibited notable differences compared to the control, suggesting that colchicine-induced mutagenesis influenced mineral accumulation in Amaranthus cruentus. The results suggest that colchicine has a dose-dependent effect on the morphological characteristics, mineral and phytochemical compositions of the plant.
Modification of bitter yam (<i>Dioscorea dumetorum</i>) starch by octenyl succinic anhydride and microwave irradiation treatment: Preparation, morphology, structure, and functionality
Authors: Awokoya K.N. , Oninla V.O. , Famojuro A.T. , Adeola S.O. , Aminu N.F. , Odekanle S.O , Ukeka B.C. 
Published: January 2025

Starch was extracted from bitter yam (Dioscorea dumetorum) and subsequently modified through esterification (succinylation) and microwave treatment. The functional properties of the starches were then examined. Proximate composition analysis showed that, after modification, the succinylated (OSABS) and microwavetreated (MTBS) starches exhibited lower moisture content but higher levels of protein, ash, crude fiber, and fat compared to the untreated bitter yam starch (UBS). Both modifications substantially improved the swelling power and solubility profile of OSABS and MTBS at 80 °C. SEM micrographs revealed no surface damage for the OSABS sample, but showed major granule damage for the MTBS, with the granules appearing shriveled and collapsed. The starches were further characterized using FTIR, TGA, XRD, and light spectroscopy. Gelation studies indicated that the UBS sample is a superior gelling agent compared to the modified derivatives. All forms of modification raised the pasting temperature but reduced the peak, trough, breakdown, setback, and final viscosities. Additionally, the modified starches demonstrated excellent paste clarity and pasting properties, making them suitable for specific applications in the industries. Overall, modifying bitter yam starch resulted in changes to its properties, thus, using octenyl succinic anhydride and microwave treatment may be a superior alternative to conventional modification methods.