bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation and Analysis of Lipid Profiles and Inflammatory Markers in Psoriasis Patients: A Retrospective Study of 200 Clinical Psoriasis Patients
Authors: Zhang Boping , Qu Tiange , Hou Xianliang , Li Linging , Wu Fenfang 
Published: December 2023

Abstract
Objectives
This study aims to explore the relationship between metabolic markers and inflammatory indicators in patients with psoriasis, specifically focusing on forms characterized by erythroderma and pustular lesions.
Design & Methods
We analyzed data from patients treated at the Department of Dermatology, Dongzhimen Hospital, affiliated with Beijing University of Chinese Medicine, between January 2010 and May 2023. A retrospective statistical methodology was employed to thoroughly examine the collected data.
Results
A significant correlation was observed between serum albumin (ALB) levels and psoriasis, particularly in cases with erythroderma and pustular lesions. ROC curve analysis revealed that patients with ALB levels below 33g/L are at increased risk for these specific psoriasis forms. Serum albumin (ALB) was positively correlated with total cholesterol (CHOL), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) (p < 0.05), while it was negatively correlated with C-reactive protein (CRP), IgE, and IL-6 (p < 0.05). CRP was positively correlated with IL-6 (Spearman r = 0.551, p < 0.01), serum complement C1q (Spearman r = 0.28, p < 0.01), and IgE (Spearman r = 0.273, p < 0.01).
Conclusion
Patients with ALB levels below 33g/L have a higher risk and prevalence of erythrodermic and pustular psoriasis. These findings suggest that ALB could serve as a novel biomarker for differentiating between plaque psoriasis and erythrodermic and pustular psoriasis.
Microalgae cultivation in bio-electrochemical systems
Authors: Mishra A. , Chhabra M. 
Published: December 2023

Abstract
Biofuels from algae have the potential to completely replace fossil-based fuels and provide energy security for the future. However, the cost of algae biofuels is still too high for commercial application. In this context, producing algae and electrical energy using photosynthetic microbial fuel cells (PMFCs) is an attractive option. PMFCs utilize the natural process of photosynthesis for algae generation or algae degradation at the anode. In the former system, the process of organic matter degradation complements the process of algae biomass production with concomitant power generation. Electrogenic bacteria oxidize organic matter at the anode anaerobically. The anode transfers the electrons released through oxidation to the cathode, where photosynthetic organisms produce oxygen (O2) as a cathodic electron acceptor. The suitability of bio-electrochemical systems such as microbial fuel cells for algae cultivation can be assessed by comparing them with the conventional method of cultivation, namely open ponds and photobioreactors. PMFCs offer a process that can provide high carbon dioxide concentrations for algal growth, has a mechanism to prevent high inhibitory O2 concentrations and can meet a fraction of the process electricity requirements. The algae biomass can go as high as 4–5 g/L in a PMFC and power output doubles due to activity of algae at the cathode compartment. This chapter discusses the algal growth in bio-electrochemical systems, the factors that influence them and directions for future research.
Tritium contents in drinking and surface seawaters before the nuclear power plant planned in Sinop (Türkiye) and their radiological risks on human population
Authors: Dizman Serdar , Aşık Feyza Zeynep , Özçelik Ali Erdem , Keser Recep , Görür Filiz Korkmaz 
Published: December 2023

AbstractThis study aims to determine the background levels of tritium radioisotope in drinking and seawater samples of Sinop province before the nuclear power plant was established in Sinop. In this context, a total of 174 water samples were collected, these are as follows: nine drinking water samples from the Sinop center and districts and 165 seawater samples from the seacoast from Samsun to Kastamonu. Tritium concentrations in the collected water samples were measured by the liquid scintillation counter. The minimum detectable activity for the method used was found to be 1.48 Bq/L. The tritium concentrations of the seawater and drinking water samples were found in the range of &lt;MDA (minimum detectable activity)-6.29 Bq/L and 2.45–3.17 Bq/L, respectively. In addition, the annual effective dose rates of the people consuming these drinking waters due to the tritium radioisotope were calculated separately for infants, children and adults and found to be 12.12, 16.96 and 35.38 nSv, respectively.
Hydrogen peroxide preoxidation as a strategy for enhanced antimicrobial photodynamic action against methicillin-resistant Staphylococcus aureus
Authors: Sammarro Silva Kamila Jessie , Lima Alessandra Ramos , Dias Lucas Danilo , de Souza Mariana , Nunes Lima Thalita Hellen , Bagnato Vanderlei Salvador 
Published: December 2023

Abstract

Antimicrobial photodynamic treatment (aPDT) is a photooxidative process based on the excitation of a photosensitizer (PS) in the presence of molecular oxygen, under specific wavelengths of light. It is a promising method for advanced treatment of water and wastewater, particularly targeting disinfection challenges, such as antibiotic-resistant bacteria (ARB). Research in improved aPDT has been exploring new PS materials, and additives in general. Hydrogen peroxide (H2O2) a widely applied disinfectant, mostly in the food industry and clinical settings, present environmentally negligible residuals at the usually applied concentrations, making it friendly for the water and wastewater sectors. Here, we explored the effects of preoxidation with H2O2 followed by blue light-mediated (450 nm) aPDT using curcumin (a natural-based PS) against methicillin-resistant Staphylococcus aureus (MRSA). Results of the sequential treatment pointed to a slight hampering in aPDT efficiency at very low H2O2 concentrations, followed by an increasing cooperative effect up to a deleterious point (≥7 log10 inactivation in CFU mL–1), suggesting a synergistic interaction of preoxidation and aPDT. The increased performance in H2O2-pretreated aPDT encourages studies of optimal operational conditions for the assisted technology and describes potentials for using the described strategy to tackle the issue of ARB spread.
A Comparative Analysis of Renal Neoplasms with Immunohistochemistry
Study: Bahrain Experience
Authors: Alkhalifa Haya Khaled Ali Abdulla , Husain Khaled Hameed , Nagaraj Veena , Raees Ayman , Darwish Abdulla 
Published: December 2023

Background::
The incidence of renal neoplasms has been increasing globally. Immunohistochemistry aids in differentiating the subtypes of Renal Cell
Carcinoma (RCC).

Objective::
This study aimed to describe the demography of renal cancer in the Kingdom of Bahrain, comparing it to other regions worldwide, emphasizing the
most common type of renal cancer, clinical presentation, and immunohistochemistry.

Methodology::
This retrospective chart review comprises 74 Bahraini patients diagnosed with Renal neoplasms (from 2009-2019) at the Bahrain Defense Force
(BDF) Hospital in the Kingdom of Bahrain. Variables collected include demographics, clinical presentation from patients’ electronic records and
pathology registry, surgical management, immunohistochemistry, pathological staging, grading, and prognosis. IBM SPSS Statistics, version
28.0.0.0, was used.

Results::
About 71 patients’ characteristics were analyzed; 63 had malignant neoplasms, and 8 had benign neoplasms. The mean age of patients with a
malignant renal neoplasm was 56.38 (± 12.643). The most common presentation was an incidental finding (60.6% of lesions being right-sided).
Clear Cell RCC was the most common malignant lesion (77.1%), and the most common stage was stage 1 (69.8%). CD10 and vimentin were
100% sensitive for Clear Cell RCC. No significant association was found between diabetes and a higher Fuhrman grade (3 or 4) (P = 0.066).

Conclusion::
From 2009 to 2019, renal neoplasms incidence increased. The most common malignant neoplasm was clear cell RCC and among benign tumours
was oncocytoma. Immunohistochemistry plays an important role in subtype determination. One recommendation would be to assess the incidence
of renal neoplasms in other hospitals in Bahrain to establish more epidemiological data and compare our results with other Gulf hospitals
Protein Profiling of Hirudo orientalis During Different Seasons for Obtaining Accurate Results in Leech Therapy
Authors: Amani Leili , Ardakani Mehran Mirabzadeh , Motamed Nasrin , Malek Masuomeh , Shasaltaneh Marzieh Dehghan 
Published: December 2023

Objective:
Leech therapy has been used for centuries as a recommended approach to
cure several diseases, such as; psoriasis, arthrosclerosis, urinary tract diseases, and wound healing.
The present study aimed to analyze the number, quantity, and distribution differences of medicinal
leech (Hirudo orientalis) proteins throughout various seasons and in laboratory conditions as well.

Methods:
Protein profiling of salivary gland secretion from leech was studied by SDS-PAGE and
2D Electrophoresis on the proteins with the molecular weight range of 5 - 250 KDa in the lyophilized
salivary gland secretion (SGS) during the seasons of summer and winter, and also in the laboratory
conditions.

Results:
Our results indicated differences in the number and quality of leech saliva proteins in different
seasons. We observed a higher number of proteins in summer than in winter. These results
demonstrated the presence of Calin and Manillase in summer and Hyaluronidase and Collagenase
in winter.

Conclusion:
This study could help us in choosing the best and most favorable conditions for using
H. orientalis proteins for the treatment of different diseases.
The Enhancement of Hepatic Parenchyma and Portal Vein in different CLD
Groups: A Comparative Study of Gadoxetic Acid and Gadopentetate
Dimeglumine
Authors: Du Yan-Ni , Liu Yan-LI , Guan Chun-Shuang , Lv Zhi-Bin , Xing Yu-Xue , Xue Ming , Xie Ru-Ming 
Published: December 2023

Background::
Chronic liver disease (CLD) will affect the enhancement of hepatic parenchyma and portal vein on abdominal-enhanced MRI.

Objective::
To investigate the difference in liver parenchyma and portal vein enhancement in patients with CLD of different liver function grades between Gd-
EOB-DTPA and Gd-DPTA in the portal venous phase (PVP).

Methods::
This retrospective study included 218 patients with CLD who had undergone abdominal enhanced MRI from January 2019 to June 2020. Patients
with various degrees of liver dysfunction were identified with Child-Turcotte-Pugh and albumin-bilirubin grade. Two readers measured the
precontrast and PVP signal intensities of liver parenchyma, portal vein, spleen, and psoas muscle. Relative liver enhancement, liver-to-spleen
contrast index, portal vein image contrast, and portal vein-to-liver contrast were calculated.

Results::
The relative enhancement of liver parenchyma was significantly lower for the Gd-EOB-DTPA group in any degree of liver function than the Gd-
DTPA group in the PVP. The Gd-EOB-DTPA group showed significantly lower portal vein-to-liver contrast in the overall study population, CTP
class B, and ALBI grade 2 patients compared to the group of Gd-DTPA at PVP. No significant difference was noted in the portal vein image
contrast between the two contrast agents, regardless of CTP and ALBI grading.

Conclusion::
In CLD patients, Gd-EOB-DTPA yielded lower liver parenchymal enhancement and similar portal vein image contrast compared to Gd-DTPA in
the PVP. Portal vein-to-liver contrast in the Gd-EOB-DTPA group was lower in the CTP class B and ALBI grade 2 subgroups compared to the Gd-
DTPA group.
Identifying Pathological Myopia Associated Genes with A Random
Walk-Based Method in Protein-Protein Interaction Network
Authors: Zhang Jiyu , Huang Tao , Sun Qiao , Zhang Jian 
Published: December 2023

Background:
Pathological myopia, a severe variant of myopia, extends beyond the typical
refractive error associated with nearsightedness. While the condition has a strong genetic
component, the intricate mechanisms of inheritance remain elusive. Some genes have been associated
with the development of pathological myopia, but their exact roles are not fully understood.

Objective:
This study aimed to identify novel genes associated with pathological myopia.

Methods:
Our study leveraged DisGeNET to identify 184 genes linked with high myopia and 39
genes related to degenerative myopia. To uncover additional pathological myopia-associated
genes, we employed the random walk with restart algorithm to investigate the protein-protein interactions
network. We used the previously identified 184 high myopia and 39 degenerative myopia
genes as seed nodes.

Results:
Through subsequent screening tests, we discarded genes with weak associations, yielding
103 new genes for high myopia and 33 for degenerative myopia.

Conclusion:
We confirmed the association of certain genes, including six genes that were confirmed
to be associated with both high and degenerative myopia. The newly discovered genes are
helpful to uncover and understand the pathogenesis of myopia.
A Review on High-speed Electric Spindle Dynamics Modeling and Vibration Response Research
Authors: Dai Ye , Qiao Binbin , Chen Xinda , Pan Gaofeng 
Published: December 2023

Background:
One of the main directions of modern technology in the field of precision
machining is high-speed operation. The spindle system is commonly utilized in this kind of operation,
and the electric spindle is the main preference among high-speed machine tool spindles.

Objective:
High-speed electric spindle vibration characteristics affect the machining accuracy of
the machine tool and the quality of the workpiece, so the research on high-speed electric spindle
vibration characteristics has important engineering practical significance.

Methods:
The research status of high-speed electrospindle at home and abroad has been summarized
in this paper. Combined with the patents related to the dynamics modelling of electrospindle,
the research on the dynamics modelling of high-speed electrospindle is analyzed. On this basis,
the computational and analytical methods for the vibration modelling of the electrospindle, including
the transfer matrix method and the finite element method, are investigated, the theoretical
foundations of these methods are discussed in depth, and the advantages and disadvantages of the
methods are evaluated. The applicability and limitations of the two methods are also compared.

Results:
The analysis has shown that the current research on the vibration characteristics of highspeed
electrospindle is mainly based on mechanical modal analysis and electromagnetic analysis.
At present, the dynamic modeling of the electrospindle mainly includes bearing modeling, shaft
bearing modeling, spindle-case modeling, electrospindle electromechanical coupling modeling,
electrospindle thermal coupling modeling, etc. The correctness of the modelling theory is verified
through experimental and simulation results. Although these models tend to be perfected, they are
still insufficient in the case of multiple influencing factors coupling and need further development.

Conclusion:
Finally, through the analysis of the patent and dynamic characteristics related to the
high-speed electric spindle, thermal deformation, magnetic tension, material, and other factors
should be considered comprehensively, and these factors should be coupled to establish an overall
dynamics model for the vibration characteristics analysis. The dynamic modelling, vibration modelling
method, and vibration characteristics of the high-speed electric spindle have been summarized
in this study, and the outlook is presented.
A Distorted Light Field Image Correction Method Based on Improved
Hough Transform
Authors: Zhang Ruihua , Bi Shubo 
Published: December 2023

Introduction:
In using a camera to take photos, due to environmental limitations,
uneven lighting can cause uneven distribution of the image light field, resulting in distortion of
the image background and target, blurring of details, and distorted light field images.

Method:
In view of this, research is conducted on the correction of distorted light field images
based on the Hough transform. First, the improved Hough transform is utilized to locate the
four coordinates, the matrix information of the normal image is applied to calculate the corresponding parameter amount, and then the low-frequency part of the image spectrum is removed. Finally, it uses the Gaussian function for difference, inputs the original data, and gets
the correction result of the distorted light field image.

Result:
The research results indicate that in the practical application of the distorted light field
image correction algorithm based on the Hough transform, the improved Hough transform algorithm is superior to the traditional one.

Conclusion:
In comparative experiments, the research algorithm outperforms the other three
algorithms, with an average color restoration of 93.76% and an average signal-to-noise ratio of
54.22dB. The superiority of the research algorithm has been verified, indicating that the research method can perfectly correct distorted light field images and achieve good correction
results.
Measuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4
Authors: Colonna Giulia , Hoye Jocelyn , de Laat Bart , Stanley Gelsina , Ibrahimy Alaaddin , Tinaz Sule , Morris Evan D 
Published: December 2023

BackgroundParkinson disease (PD) is the second most common neurodegenerative disease, affecting approximately 1% of the world’s population. Increasing evidence suggests that aerobic physical exercise can be beneficial in mitigating both motor and nonmotor symptoms of the disease. In a recent pilot study of the role of exercise on PD, we sought to confirm exercise intensity by monitoring heart rate (HR). For this purpose, we asked participants to wear a chest strap HR monitor (Polar Electro Oy) and the Fitbit Charge 4 (Fitbit Inc) wrist-worn HR monitor as a potential proxy due to its convenience. Polar H10 has been shown to provide highly accurate R-R interval measurements. Therefore, we treated it as the gold standard in this study. It has been shown that Fitbit Charge 4 has comparable accuracy to Polar H10 in healthy participants. It has yet to be determined if the Fitbit is as accurate as Polar H10 in patients with PD during rest and exercise.ObjectiveThis study aimed to compare Fitbit Charge 4 to Polar H10 for monitoring HR in patients with PD at rest and during an intensive exercise program.MethodsA total of 596 exercise sessions from 11 (6 male and 5 female) participants were collected simultaneously with both devices. Patients with early-stage PD (Hoehn and Yahr ≤2) were enrolled in a 6-month exercise program designed for patients with PD. They participated in 3 one-hour exercise sessions per week. They wore both Fitbit and Polar H10 during each session. Sessions included rest, warm-up, intense exercise, and cool-down periods. We calculated the bias in the HR of the Fitbit Charge 4 at rest (5 min) and during intense exercise (20 min) by comparing the mean HR during each of the periods to the respective means measured by Polar H10 (HRFitbit – HRPolar). We also measured the sensitivity and specificity of Fitbit Charge 4 to detect average HRs that exceed the threshold for intensive exercise, defined as 70% of an individual’s theoretical maximum HR. Different types of correlations between the 2 devices were investigated.ResultsThe mean bias was 1.68 beats per minute (bpm) at rest and 6.29 bpm during high-intensity exercise, with an overestimation by Fitbit Charge 4 in both conditions. The mean bias of the Fitbit across both rest and intensive exercise periods was 3.98 bpm. The device’s sensitivity in identifying high-intensity exercise sessions was 97.14%. The correlation between the 2 devices was nonlinear, suggesting Fitbit’s tendency to saturate at high values of HR.ConclusionsThe performance of Fitbit Charge 4 is comparable to Polar H10 for assessing exercise intensity in a cohort of patients with PD (mean bias 3.98 bpm). The device could be considered a reasonable surrogate for more cumbersome chest-worn devices in future studies of clinical cohorts.
Characterizing and Comparing Adverse Drug Events Documented in 2 Spontaneous Reporting Systems in the Lower Mainland of British Columbia, Canada: Retrospective Observational Study
Authors: Lau Erica Y , Cragg Amber , Small Serena S , Butcher Katherine , Hohl Corinne M 
Published: December 2023

Background
Robust adverse drug event (ADE) reporting systems are crucial to monitor and identify drug safety signals, but the quantity and type of ADEs captured may vary by system characteristics.

Objective
We compared ADEs reported in 2 different reporting systems in the same jurisdictions, the Patient Safety and Learning System–Adverse Drug Reaction (PSLS-ADR) and ActionADE, to understand report variation.

Methods
This retrospective observational study analyzed reports entered into PSLS-ADR and ActionADE systems between December 1, 2019, and December 31, 2022. We conducted a comprehensive analysis including all events from both reporting systems to examine coverage and usage and understand the types of events captured in both systems. We calculated descriptive statistics for reporting facility type, patient demographics, serious events, and most reported drugs. We conducted a subanalysis focused on adverse drug reactions to enable direct comparisons between systems in terms of the volume and events reported. We stratified results by reporting system.

Results
We performed the comprehensive analysis on 3248 ADE reports, of which 12.4% (375/3035) were reported in PSLS-ADR and 87.6% (2660/3035) were reported in ActionADE. Distribution of all events and serious events varied slightly between the 2 systems. Iohexol, gadobutrol, and empagliflozin were the most common culprit drugs (173/375, 46.2%) in PSLS-ADR, while hydrochlorothiazide, apixaban, and ramipril (308/2660, 11.6%) were common in ActionADE. We included 2728 reports in the subanalysis of adverse drug reactions, of which 12.9% (353/2728) were reported in PSLS-ADR and 86.4% (2357/2728) were reported in ActionADE. ActionADE captured 4- to 6-fold more comparable events than PSLS-ADR over this study’s period.

Conclusions
User-friendly and robust reporting systems are vital for pharmacovigilance and patient safety. This study highlights substantial differences in ADE data that were generated by different reporting systems. Understanding system factors that lead to varying reporting patterns can enhance ADE monitoring and should be taken into account when evaluating drug safety signals.