bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of flow cytometric immunophenotyping in the diagnosis of breast implant‐associated anaplastic large cell lymphoma: A 6‐year, single‐institution experience
Authors: Chan Alexander , Auclair Romany , Gao Qi , Ghione Paola , Horwitz Steven , Dogan Ahmet , Roshal Mikhail , Lin Oscar 
Published: February 2024

AbstractBreast implant‐associated anaplastic large cell lymphoma (BIA‐ALCL) is an uncommon mature T‐cell neoplasm occurring in patients with textured breast implants, typically after 7–10 years of exposure. Although cytopathologic or histopathologic assessment is considered the gold standard diagnostic method for BIA‐ALCL, flow cytometry (FC)‐based immunophenotyping is recommended as an adjunct test. However, the diagnostic efficacy of FC is not well reported. We reviewed 290 FC tests from breast implant pericapsular fluid and capsule tissue from 182 patients, including 16 patients with BIA‐ALCL over a 6‐year period, calculating diagnostic rates and test efficacy. FC showed an overall sensitivity of 75.9%, specificity of 100%, and negative and positive predictive values of 95.4% and 100%, respectively. Blinded expert review of false‐negative cases identified diagnostic pitfalls, improving sensitivity to 96.6%. Fluid samples had better rates of adequate samples for FC testing compared with tissue samples. Paired with FC testing of operating room (OR)‐acquired fluid samples, capsulectomy FC specimens added no diagnostic value in patients with concurrent fluid samples; no cases had positive capsule FC with negative fluid FC. Fluid samples are adequate for FC testing more often than tissue. Capsule tissue FC specimens do not improve FC efficacy when paired with OR‐acquired fluid FC samples and are often inadequate samples. FC is 100% specific for BIA‐ALCL and can serve as a confirmatory test but should not be the sole diagnostic method. Awareness of sample‐specific diagnostic pitfalls greatly improves the sensitivity of BIA‐ALCL testing by FC.
Olanzapine for young PEople with aNorexia nervosa (OPEN): A protocol for an open‐label feasibility study
Authors: Said Olena , Sengun Filiz Ece , Stringer Dominic , Applewhite Briana , Kellermann Vanessa , Mutwalli Hiba , Bektas Sevgi , Akkese Melahat Nur , Kumar Ashish , Carter Ben , Simic Mima , Sually Dilveer , Bentley Jessica , Young Allan H. , Madden Sloane , Byford Sarah , Landau Sabine , Lawrence Vanessa , Treasure Janet , Schmidt Ulrike , Nicholls Dasha , Himmerich Hubertus 
Published: February 2024

AbstractIntroductionAntipsychotics are routinely prescribed off‐label for anorexia nervosa (AN) despite limited evidence. This article presents a protocol of a study aiming to assess the feasibility of a future definitive trial on olanzapine in young people with AN.Methods and analysisIn an open‐label, one‐armed feasibility study, 55 patients with AN or atypical AN, aged 12–24, receiving outpatient, inpatient or day‐care treatment who are considered for olanzapine treatment will be recruited from NHS sites based in England. Assessments will be conducted at screening, baseline and at 8‐, 16 weeks, 6‐ and 12 months. Primary feasibility parameters will be proportions of patients who agree to take olanzapine and who adhere to treatment and complete study assessments. Qualitative methods will be used to explore acceptability of the intervention and study design. Secondary feasibility parameters will be changes in body mass index, psychopathology, side effects, health‐related quality of life, carer burden and proportion of participants who would enrol in a future randomised controlled trial. The study is funded by the National Institute for Health Research via Health Technology Assessment programme.DiscussionOlanzapine for young PEople with aNorexia nervosa will inform a future randomised controlled trial on the efficacy and safety of prescribing olanzapine in young people with AN.
The combined effect of family environment and parents' characteristics on the use of food to soothe children
Authors: Lozano‐Casanova Mar , Sospedra Isabel , Oliver‐Roig Antonio , Richart‐Martinez Miguel , Gutierrez‐Hervas Ana 
Published: February 2024

AbstractParental feeding practices, such as the use of food to soothe, can be shaped by various factors, including the family environment and parents' psychological characteristics and capacities. To our knowledge, the combined effect of these factors has not been studied. Furthermore, parental feeding practices have mainly been studied in women, resulting in a gender gap in the research. This study aims to investigate the combined effect of family environment and parental characteristics on the likelihood of using food to soothe children, taking the gender of both parents into account. This cross‐sectional study included a sample of 846 parents (36.3% men) of 1‐year‐old children from different regions of Spain. Participants completed an online survey that included questionnaires to measure whether parents used food to soothe children, the family environment, parents' characteristics, and their psychological capacities. Binary logistic regression analyses were performed to identify associations between the variables. The final model showed that, within the family environment, higher levels of dyadic adjustment between couples (OR = 0.965; p = .026) were associated with a reduced likelihood of using food to soothe children, whereas the psychological characteristic of parental fatigue (OR = 1.053; p = .007) appeared to be associated with an increased likelihood. Also associated with an increased likelihood of this practice were higher parental sense of competence (OR = 1.028; p = .029) and the attention dimension of emotional intelligence (OR = 1.043; p = .007). Our study suggests that using food to soothe children may be influenced by factors at different levels, from the quality and adjustment of the couple's relationship to parental fatigue, self‐competence, and emotional intelligence. For future research, it may be worthwhile contextualizing parental practices to gain a better understanding of children's behavior.
The Bitcoin price and Bitcoin price uncertainty: Evidence of Bitcoin price volatility
Authors: Köse Nezir , Yildirim Hakan , Ünal Emre , Lin Boqiang 
Published: February 2024

AbstractThis study examines the Bitcoin price by taking into account global factors, including the Chicago Board Options Exchange's Market Volatility Index (VIX), the US dollar index, the gold price, the oil price, and Bitcoin price volatility. The analysis is conducted using the structural vector autoregression (SVAR) model. The variance decomposition findings revealed that the influence of the VIX on the Bitcoin price was initially restricted, but progressively intensified over time. Among the indicators, Bitcoin price volatility had the highest explanatory share in both daily and weekly data analysis. The impulse response functions demonstrated a statistically significant inverse relationship between the VIX and the Bitcoin price. Furthermore, the analysis revealed that the Bitcoin price was mostly impacted by its own volatility. This implies that investing in Bitcoin requires a certain level of risk‐taking.
MNCs' corporate social irresponsibility and foreign subsidiary performance
Authors: Nuruzzaman N. , Makarius Erin E. , Mukherjee Debmalya , Gaur Ajai 
Published: February 2024

AbstractResearch SummaryBuilding on the cognitive view of stakeholder evaluation, we propose that multinational corporations' (MNCs') socially irresponsible acts transcend geographic boundaries and negatively affect foreign subsidiary performance. Moreover, we propose that foreign subsidiaries' product innovation and marketing campaigns create strategic noise in the information space that can mitigate the negative effect of MNCs' corporate social irresponsibility (CSI) incidents occurring elsewhere on the performance of their foreign subsidiaries. We test our arguments on 335 subsidiaries of 42 multinational grocery retailers from 18 different home countries. Our analyses, based on a sample of 2185 subsidiary‐year observations over the period of 9 years (2012–2020), largely support our core argument that CSI incidents negatively influence the sales growth of foreign subsidiaries.Managerial SummaryThis research underscores the importance for MNC managers to be cognizant of the potential fallout from CSI incidents. With the global spread of information, MNCs' misconduct that occurs elsewhere can quickly impact the sales growth of foreign subsidiaries. The study found that product or service innovations are more effective than marketing campaigns in managing reputational damage, emphasizing the value of genuine, capability‐enhancing strategies. Furthermore, the findings highlight the interconnectedness between socially responsible practices and innovation, suggesting that MNCs and their subsidiaries should focus on maintaining strong ethical standards while simultaneously fostering an environment conducive to innovation. This approach not only addresses the adverse effects of CSI but also strengthens the MNC's overall standing with its stakeholders.
Addressing the workforce crisis in (rural) social care: A scoping review
Authors: Carson Dean B. , Johansson Albert Brunet , Schaumberg Mia , Hurtig Anna‐Karin 
Published: February 2024

AbstractBackgroundThis scoping review identifies strategies potentially addressing the ‘workforce crisis’ in rural social care. The increasing global demand for social care has been coupled with widely recognised challenges in recruiting and retaining sufficient staff to provide this care. While the social care workforce crisis is a global phenomenon, it is particularly acute in rural areas.MethodsThe review identified 75 papers which (i) had been published since 2017, (ii) were peer reviewed, (iii) concerned social care, (iv) were relevant to rural settings, (v) referenced workforce shortages, and (vi) made recommendations for ways to address those shortages. Thematic synthesis was used to derive three analytical themes with a combined 17 sub‐themes applying to recommended strategies and evidence supporting those strategies.ResultsThe most common strategies for addressing social care workforce shortages were to improve recruitment and retention (‘recruit and retain’) processes without materially changing the workforce composition or service models. Further strategies involved ‘revitalising’ the social care workforce through redeploying existing staff or identifying new sources of labour. A small number of strategies involved ‘re‐thinking’ social care service models more fundamentally. Very few papers specifically considered how these strategies might apply to rural contexts, and evidence for the effectiveness of strategies was sparse.ConclusionThe review identifies a significant gap in the literature in relation to workforce innovation and placed‐based studies in rural social care systems. It is unlikely that the social care workforce crisis can be addressed through continuing attempts to recruit and retain workers within existing service models.
Elucidating systemic immune responses to acute and convalescent SARS‐CoV‐2 infection in children and elderly individuals
Authors: Rajamanickam Anuradha , Nathella Pavan Kumar , Venkataraman Aishwarya , Chandrasekaran Padmapriyadarsini , Rajendraprasath Sasidaran , Devaleenal Bella D. , Pandiarajan Arul Nancy , Krishnakumar Gowshika , Venkat Ramanan Padmasani , Babu Subash 
Published: February 2024

AbstractBackgroundSevere Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2), a causative pathogen of the COVID‐19 pandemic, affects all age groups. However, various studies have shown that COVID‐19 presentation and severity vary considerably with age. We, therefore, wanted to examine the differences between the immune responses of children with COVID‐19 and elderly COVID‐19 individuals.MethodsWe analyzed cytokines, chemokines, growth factors, and acute phase proteins in acute and convalescent COVID‐19 children and the elderly with acute and convalescent COVID‐19.ResultsWe show that most of the pro‐inflammatory cytokines (interferon [IFN]γ, interleukin [IL]‐2, tumor necrosis factor‐α [TNFα], IL‐1α, IFNα, IFNβ, IL‐6, IL‐12, IL‐3, IL‐7, IL‐1Ra, IL‐13, and IL‐10), chemokines (CCL4, CCL11, CCL19, CXCL1, CXCL2, CXCL8, and CXL10), growth factors (vascular endothelial growth factor and CD40L) and acute phase proteins (C‐reactive protein, serum amyloid P, and haptoglobin) were decreased in children with acute COVID 19 as compared with elderly individuals. In contrast, children with acute COVID‐19 exhibited elevated levels of cytokines‐ IL‐1β, IL‐33, IL‐4, IL‐5, and IL‐25, growth factors—fibroblast growth factor‐2, platelet‐ derived growth factors‐BB, and transforming growth factorα as compared with elderly individuals. Similar, differences were manifest in children and elderly with convalescent COVID‐19.ConclusionThus, COVID‐19 children are characterized by distinct cytokine/chemokine/growth factor/acute phase protein markers that are markedly different from elderly COVID‐19 individuals.
Gene expression associated with vaginal bleeding in women using the 52‐mg levonorgestrel hormonal intrauterine device: A prospective study
Authors: Torelli Flávia R. , Rodrigues‐Peres Raquel M. , Lopes‐Cendes Iscia , Bahamondes Luis , Juliato Cássia R. T. 
Published: February 2024

AbstractObjectiveTo evaluate gene expression associated with vaginal bleeding in the 52‐mg hormonal intrauterine device (IUD) users.Materials and MethodsWe conducted a prospective study involving 100 women seeking to use the 52‐mg hormonal IUD for contraception. We excluded women with a history or current condition of abnormal uterine bleeding and who were unable to attend a 1‐year follow up. Women who expelled the device, removed it for reasons unrelated to vaginal bleeding, or were lost to follow up were discontinued. We collected endometrial biopsies immediately before IUD placement and assessed 20 selected genes using reverse transcription quantitative polymerase chain reaction. Users maintained a uterine bleeding diary for 12 months following IUD insertion. For statistical analysis, participants were categorized into groups with or without vaginal bleeding at 3 and 12 months.ResultsWomen with elevated CXCL9 expression had an 8.15‐fold higher likelihood of experiencing vaginal bleeding at 3 months (odds ratio [OR] 8.15, 95% confidence interval [CI] 2.24–29.61, P = 0.001). At 12 months of follow up, women with increased TIMP1 expression had a 2.74‐fold higher chance of experiencing vaginal bleeding (OR 2.74, 95% CI 1.08–6.95, P = 0.033). CXCL9 ≥ 1.5 and IL17A ≥ 0.68 were associated with a higher probability of vaginal bleeding at 3 months, while TIMP1 levels ≥0.943 were linked to an increased risk of bleeding at 12 months.ConclusionUsers of the 52‐mg hormonal IUD with elevated relative CXCL9 expression face an increased risk of vaginal bleeding at 3‐month follow up, whereas those with heightened TIMP1 expression are more likely to experience vaginal bleeding at 12 months.
The new robotic system HUGO RAS for gynecologic surgery: First European experience from Gemelli Hospital
Authors: Gioè Alessandro , Monterossi Giorgia , Gueli Alletti Salvatore , Panico Giovanni , Campagna Giuseppe , Costantini Barbara , Naldini Angelica , Pedone Anchora Luigi , Oliva Riccardo , Mastrovito Sara , Fagotti Anna , Fanfani Francesco , Scambia Giovanni 
Published: February 2024

AbstractObjectiveTo evaluate the safety and feasibility of the new surgical robot HUGO robotic assisted surgery (RAS) in a series of gynecologic surgical procedures.MethodsBetween March and October 2022, 138 patients treated at Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy were enrolled in the study. All patients suitable for a minimally‐invasive approach were prospectively included and divided into two groups: Group 1 (78 patients) made up of patients operated on for uterine and/or adnexal pathologies, and Group 2 (60 patients) made up of patients treated for pelvic organ prolapse.ResultsIn Group 1, median docking time (DT) was 5 min and median console time (CT) was 90 min. In two patients (2.6%) redocking was necessary. In two patients (2.6%), the surgeon continued the surgery laparoscopically. Intraoperative complications occurred in two surgeries (2.6%). In Group 2, median DT was 4 min and median CT was 134.5 min. In three patients (5%), redocking was necessary. In all patients, the surgery was successfully completed robotically without intraoperative complications.ConclusionsThe present study demonstrates that the new HUGO RAS system for gynecologic surgery is safe with good results in terms of surgical efficacy and perioperative outcomes. Further studies are needed to investigate its use in other technical and surgical aspects.
Diffusion Tensor and Kurtosis MRI‐Based Radiomics Analysis of Kidney Injury in Type 2 Diabetes
Authors: Yang Daoyu , Tian Chong , Liu Jian , Peng Yunsong , Xiong Zhenliang , Da Jingjing , Yang Yuqi , Zha Yan , Zeng Xianchun 
Published: February 2024

BackgroundDiffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) can provide quantitative parameters that show promise for evaluation of diabetic kidney disease (DKD). The combination of radiomics with DTI and DKI may hold potential clinical value in detecting DKD.PurposeTo investigate radiomics models of DKI and DTI for predicting DKD in type 2 diabetes mellitus (T2DM) and evaluate their performance in automated renal parenchyma segmentation.Study TypeProspective.PopulationOne hundred and sixty‐three T2DM patients (87 DKD; 63 females; 27–80 years), randomly divided into training cohort (N = 114) and validation cohort (N = 49).Field Strength/Sequence1.5‐T, diffusion spectrum imaging (DSI) with 9 different b‐values.AssessmentThe images of DSI were processed to generate DKI and DTI parameter maps, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). The Swin UNETR model was trained with 5‐fold cross‐validation using 100 samples for renal parenchyma segmentation. Subsequently, radiomics features were automatically extracted from each parameter map. The performance of the radiomics models on the validation cohort was evaluated by utilizing the receiver operating characteristic (ROC) curve.Statistical TestsMann–Whitney U test, Chi‐squared test, Pearson correlation coefficient, least absolute shrinkage and selection operator (LASSO), dice similarity coefficient (DSC), decision curve analysis (DCA), area under the curve (AUC), and DeLong's test. The threshold for statistical significance was set at P < 0.05.ResultsThe DKI_MD achieved the best segmentation performance (DSC, 0.925 ± 0.011). A combined radiomics model (DTI_FA, DTI_MD, DKI_FA, DKI_MD, and DKI_RD) showed the best performance (AUC, 0.918; 95% confidence interval [CI]: 0.820–0.991). When the threshold probability was greater than 20%, the combined model provided the greatest net benefit. Among the single parameter maps, the DTI_FA exhibited superior diagnostic performance (AUC, 887; 95% CI: 0.779–0.972).Data ConclusionThe radiomics signature constructed based on DKI and DTI may be used as an accurate and non‐invasive tool to identify T2DM and DKD.Level of Evidence2Technical EfficacyStage 2
Evaluation of ERA5 precipitation and 10‐m wind speed associated with extratropical cyclones using station data over North America
Authors: Chen Ting‐Chen , Collet François , Di Luca Alejandro 
Published: February 2024

AbstractWhile the ERA5 reanalysis is commonly utilized in climate studies on extratropical cyclones (ETCs), only a few studies have quantified its ability in the representation of ETCs over land. To address this gap, this study evaluates ERA5's skill in representing the ETC‐associated 10‐m wind speed and the precipitation in central and eastern North America during 2005–2019. Hourly data collected from ~3000 stations, amounting to around 420 million reports stored in the Integrated Surface Database, is used as reference. For the spatial‐averaged ETC properties, ERA5 shows a good skill for wind speed with normalized mean bias (NMB) of −0.7% and normalized root‐mean‐square error (NRMSE) of 14.3%, despite a tendency to overestimate low winds and underestimate high winds. The ERA5 skill is worse for precipitation than for wind speed with NMB of −10.4% and NRMSE of 56.5% and a strong tendency to underestimate high values. For both variables, the best and worst performance is found in DJF and JJA, respectively. Negative biases are often identified over regions with stronger precipitation/wind speeds, and a systematic underestimation of wind speed is found over the Rockies with complex topography. Compared to the averaged ETCs, ERA5's performance deteriorates for the top 5% extreme ETCs with a stronger tendency to underestimate both wind speed and precipitation (NMB of −10.2% and −22.6%, respectively). Furthermore, ERA5's skill is worse for local extreme values within ETCs than for spatial averages. Our results highlight some important limitations of the ERA5 reanalysis products for studies looking at the possible impacts of ETCs.
Holocene overflow events of the lower Yellow River recorded in Huangdun ancient lake, northern Jiangsu Plain, China
Authors: Zhang Rui , Xing Li , Yu Shi‐Yong , Nie Junsheng , Wu Jinjia , Wang Zhao , Chen Shiyue , Hou Zhanfang , Zhang Guodong , Zhang Denghui 
Published: February 2024

ABSTRACTOverflow events are important embodiments of the evolutionary characteristics of the lower Yellow River. Lakes in the lower reaches of the Yellow River have the capacity to record these events. Due to the complex provenance and transport pathways of sediments in local lakes, it is difficult to extract reliable information on sediments delivered by the Yellow River based on conventional methods and proxies. Here, we show results from a genetically meaningful end‐member (EM) decomposition of sediment grain‐size data from Huangdun ancient lake. The grain‐size of the sediments can be decomposed into three end‐members. Comprehensive analysis combining environmental magnetism and geochemical indicators clarifies the significance of each end‐member. EM1 represents mixed signals of various proximal fluvial sediments and the Yellow River materials. EM2 is similar to terrestrial fine‐grained debris in conjunction with local pedogenic materials, aeolian inputs and some Yi River materials. EM3 represents a component that is mainly derived from long‐distance transport by the lower Yellow River. End‐member analysis successfully identified overflow events of the lower Yellow River on a southward‐flowing path during the Holocene. This study provides a meaningful attempt to reconstruct the evolutionary history of the lower Yellow River from sedimentary records.