bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tranexamic Acid Is Safe in Patients with a History of Venous Thromboembolism Undergoing Total Joint Arthroplasty
Authors: Richardson Mary K. , Liu Kevin C. , Mayfield Cory K. , Kistler Natalie M. , Lieberman Jay R. , Heckmann Nathanael D. 
Published: November 2023

Background:Tranexamic acid (TXA) is increasingly utilized during total knee arthroplasty (TKA) and total hip arthroplasty (THA) to decrease blood loss; however, there are concerns with regard to potential thromboembolic complications, particularly in high-risk patients. This study sought to define a subset of patients at elevated risk for thromboembolic complications following total joint arthroplasty (TJA) and to compare postoperative outcomes between patients who received TXA and those who did not.Methods:Patients who underwent primary, elective TJA from 2015 to 2021 were identified in the Premier Healthcare Database. Patients with a history of venous thromboembolism, defined as a history of pulmonary embolism or deep vein thrombosis, were identified and formed the high-risk cohort. Patient demographic characteristics, hospital factors, patient comorbidities, antithrombotic medication use, perioperative blood transfusion, and 90-day complications were assessed and compared between patients who received TXA and those who did not. Univariate regression and multivariable regression were performed to account for potential confounders.Results:The high-risk cohort comprised 70,759 patients who underwent TJA, of whom 46,074 (65.1%) received TXA and 24,685 (34.9%) did not. After controlling for confounding factors, patients in the TXA cohort had similar risks of pulmonary embolism (adjusted odds ratio [OR], 0.90 [95% confidence interval (CI), 0.79 to 1.02]; p = 0.097), stroke (adjusted OR, 0.97 [95% CI, 0.69 to 1.37]; p = 0.867), and myocardial infarction (adjusted OR, 0.93 [95% CI, 0.69 to 1.24]; p = 0.614) compared with patients who did not receive TXA. Patients who received TXA demonstrated decreased risks of transfusion (adjusted OR, 0.42 [95% CI, 0.38 to 0.46]; p < 0.001) and 90-day readmission (adjusted OR, 0.87 [95% CI, 0.80 to 0.94]; p < 0.001).Conclusions:TXA utilization was not associated with an increased risk of postoperative pulmonary embolism, stroke, or myocardial infarction in patients with a history of venous thromboembolism. Furthermore, patients who received TXA had a decreased risk of transfusion and readmission. This evidence suggests that TXA may be safely utilized among select high-risk patients.Level of Evidence:TherapeuticLevel III. See Instructions for Authors for a complete description of levels of evidence.
Metallosis in Total Hip Arthroplasty
Authors: Lee Anderson , Paiement Guy D. , Penenberg Brad L. , Rajaee Sean S. 
Published: November 2023

» Metallosis is a rare but significant complication that can occur after total hip arthroplasty (THA) for a variety of reasons but most commonly in patients with metal-on-metal implants.» It is characterized by the visible staining, necrosis, and fibrosis of the periprosthetic soft tissues, along with the variable presence of aseptic cysts and solid soft tissue masses called pseudotumors secondary to the corrosion and deposition of metal debris.» Metallosis can present with a spectrum of complications ranging from pain and inflammation to more severe symptoms such as osteolysis, soft tissue damage, and pseudotumor formation.» Workup of metallosis includes a clinical evaluation of the patient's symptoms, imaging studies, serum metal-ion levels, and intraoperative visualization of the staining of tissues. Inflammatory markers such as erythrocyte sedimentation rate and C-reactive protein along with intraoperative frozen slice analysis may be useful in certain cases to rule out concurrent periprosthetic joint infection.» Management depends on the severity and extent of the condition; however, revision THA is often required to prevent rapid progression of bone loss and tissue necrosis.
Cage-confined multilevel-selective [2+2] cross-photocycloaddition beyond enantioselectivity and biomimicry
Authors: Su Cheng-Yong , Ruan Jia , Li Zhongshu , Yin Changzhen , Lu Yu-Lin , Wei Zhang-Wen , Hu Peng 
Published: November 2023

Abstract
The last decades witnessed an exciting renaissance in photochemistry where the asymmetric photocatalysis has emerged as a promising solution for stereoselectivity control in radical intermediates. However, a significant hurdle still lies in achieving a multilevel control of chemo-, regio-, diastereo-, and enantioselectivities in cross-coupling photoreactions, which often result in chaotic outcomes when partners show similar electronic and optical properties. Herein, we present a biomimetic cage-confined photocatalytic protocol that are able to precisely manipulate the excited triplet-state dynamics via stereochemical confinement. This approach enables the high-selective synthesis of heterocoupled [2+2] syn-HH (head-to-head) enantiomers from two photoactive α,β-unsaturated carbonyl compounds, which are typically challenging to access from conventional strategies due to steric hindrance and competitive pathways. We find that the cooperative heteromolecular binding dynamics beyond complementary host-guest lock-and-key fit plays a critical role in initially chemoselective and successively stereoselective photoreactions. Notably, the open-pockets featuring wide substrates-host match but products-host mismatch facilitate recycling catalysis to surmount the common problems of enzyme-mimicking cage-reactors with limited guest specificity against broad substrate scope and product inhibition against reaction turnover.
Photocatalytic Degradation of Norfloxacin Antibiotics on ZnxCd(1-x)S/g-C3N4 Composites in Water
Authors: Wu Zanen , Chen Qinjun , Wu Shibiao 
Published: November 2023

Abstract
g-C3N4/ZnxCd(1-x)S composites were synthesized by a simple hydrothermal method. The composites were characterized by X-ray diffraction, UV-vis diffuse reflectance spectroscopy, infrared spectroscopy, and electron micro-projective microscopy. According to the performance of ZnxCd(1-x)S for the photocatalytic degradation of norfloxacin under visible light in water, the best stoichiometric number of x was 0.5. The best photolytic norfloxacin degradation rate of g-C3N4/ZnxCd(1-x)S composites was 89.8%, which was obtained when the dosage ratio of g-C3N4 to ZnxCd(1-x)S was 1:1.
Effect of Dietary Eucommia ulmoides Oliver polysaccharide on Immune Function and Meat Quality of Songliao Black Pigs
Authors: Liang Yang , Tang Zeyu , Wang Hao , Liu Meng , Zhao Fanglin , Wang Longsheng , Meng Yinbiao , Jia Lijun 
Published: November 2023

Abstract

Eucommia ulmoidesis a traditional Chinese herbal medicine, with pharmacological effects such as lowering blood pressure and enhancing immune function. The effects of dietaryEucommia ulmoidespolysaccharide (EUP) on immune function and meat quality were studied in Songliao Black Pigs. Blood lymphocyte counts and percentage, concentrations of serum total protein and of albumin increased, whereas those of urea nitrogen and triglyceride decreased. White blood cell and lymphocyte counts, and serum IgA, IgE, IgG2 a and IFN-γ increased. Average daily weight gain, slaughter weight, lean meat rate and cooked meat rate increased, whereas PH24, feed-weight ratio, fat rate, yellowness (b*) and centrifugal dehydration rate decreased. Transcriptome sequencing detected 32 differentially expressed genes (DEGs), with 26 up-regulated and six down-regulated. A total of 19 genes were differentially expressed in the four groups, 18 of which were up-regulated. The DEGs included ADAMTS4, PER1, STAC, SERPINE1, FASN, THRSP, SP7 and KRT80 and the protein interaction network showed 20 up-regulated nodes, three down-regulated nodes and 14 DEGs. GO functional annotation and enrichment analysis showed that 34 items were significantly enriched, including transferase activity, actin binding, acetyl coenzyme A, acyl coenzyme A metabolism, adipose tissue development and acyl glycerol homeostasis. KEGG pathway analysis showed that the AMPK and PPAR signaling pathways were enriched. DietaryEucommiapolysaccharide enhanced immune function in Songliao Black Pigs, improved growth and carcass performance, increased the expression of genes related to meat quality traits and improved meat quality.
Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.
Authors: Liu Wei , Jia Qinyuan , Zhu Yuheng , Yao Hong-fei , Yin Yifan , Duan Zonghao , Zheng Jia-hao , Ma Ding , Yang Min-Wei , Yang Jian-yu , Zhang Junfeng , Liu De-jun , Hua Rong , Huo Yan-Miao , Xue-Liang Fu , Sun Yong-Wei 
Published: November 2023

Abstract

Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma (PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemcitabine), fluorouracil-based regiments such as FOLFIRINOX regimen (5-fluorouracil (5-FU), oxaliplatin, Irinotecan) and platinum-based regimens, especially for patients with BRCA mutations. Large amounts of work have been done on exploring the mechanism underlying resistance of gemcitabine-based and platinum-based regimens, while little research has been achieved on the mechanism of FOLFIRINOX regimens resistance in PDAC. In this study, we found that Polypeptide N-Acetylgalactosaminyltransferase 5 (GALNT5) was highly expressed in PDAC tissues and predicted poor prognosis in PDAC via the analysis of Renji tumor micro-assays (TMA), TCGA datasets, GTXs datasets, and GEO datasets. Moreover, we observed that GALNT5 promoted FOLFIRINOX resistance and cell proliferation at the same time, and proposed that GALNT5-induced oxaliplatin instead of 5-FU resistance may be the cause of FOLFIRINOX resistance. Meanwhile, GALNT5-induced FOLFIRINOX resistance was amplified by enhancing DNA damage repair instead of the usual mechanisms of 5-FU-based regimens resistance associated with cancer stem cells. Furthermore, we displayed mass spectrum and CO-immunoprecipitation (CO-IP) and found that GALNT5 interacted with MYH9, thus participating in the activation of the NOTCH pathways, resulting in hampering FOLFIRINOX-induced DNA damage. Functions of GALNT5 promoting FOLFIRINOX resistance were validated in vivo via a mouse PDAC orthotopic model. Hence, we identified GALNT5 as a vital regulator and a potential therapeutic target in FOLFIRINOX regimen resistance.
Misconceptions about temperature compensation in experimental stress analysis
Authors: Xiong Sidong , Zhang Kaiyin 
Published: November 2023

Abstract
Resistance strain testing technology is widely used in engineering structures to obtain the strain response of the structure and analyze the accurate stress state of the structure. By analyzing the working principle of the resistance strain sensor and its corresponding temperature compensation principle, and recognizing the interrelation of the temperature strain of the structure, the temperature strain of the compensation block and the temperature strain of the resistance strain sensor, the mistake of the principle of temperature compensation in the structural resistance strain testing technology is revealed. It is the conceptual confusion between structural temperature strain and compensation block temperature strain that leads to the mistake in temperature strain compensation. The test results not only do not eliminate the temperature strain of the structure, but also add the effect of temperature stress. However, when the component is not subjected to mechanical loads, the current structural strain testing technique based on the temperature strain compensation is effective in obtaining the temperature stresses in the component.
Observation of the Antimatter Hypernucleus $^4_{\bar{\Lambda}}\overline{\hbox{H}}$
Authors: Qiu Hao , Wu Junlin 
Published: November 2023

Abstract

Matter-antimatter asymmetry is a research topic of fundamental interest, as it is the basis for the existence of the matter world, which survived annihilation with antimatter in the early Universe. High energy nuclear collisions create conditions similar to the Universe microseconds after the Big Bang, with comparable amounts of matter and antimatter. Much of the antimatter created escapes the rapidly expanding fireball without annihilation, making such collisions an effective experimental tool to create heavy antimatter nuclear objects and study their properties. In this paper, we report the first observation of the antimatter hypernucleus $^4_{\bar{\Lambda}}\overline{\hbox{H}}$, composed of an $\bar{\Lambda}$, an antiproton and two antineutrons. The discovery was made through its two-body decay after production in ultrarelativistic heavy ion collisions by the STAR experiment at the Relativistic Heavy Ion Collider. In total, 15.6 candidate $^4_{\bar{\Lambda}}\overline{\hbox{H}}$ antimatter hypernuclei are obtained with an estimated background count of 6.4. Lifetimes of the antihypernuclei $^3_{\bar{\Lambda}}\overline{\hbox{H}}$ and $^4_{\bar{\Lambda}}\overline{\hbox{H}}$ are measured and compared with lifetimes of their corresponding hypernuclei, testing the symmetry between matter and antimatter. Various production yield ratios among (anti)hypernuclei and (anti)nuclei are also measured and compared with theoretical model predictions, shedding light on their production mechanism.
Beverage consumption and diabetic retinopathy: a two-sample Mendelian randomization study
Authors: sun xufang , rao suyun , zhou ziqing , wang ruohong , tan yuhe 
Published: November 2023

Abstract

Background
Observational studies on the association between beverage intake and diabetic retinopathy (DR) remain controversial. We aimed to investigate the causal relationship between beverage consumption (coffee, juice, yogurt, tea, alcohol, milk) and DR via the two-sample Mendelian randomization (MR) approach.
Methods
We use genome-wide association study summary level data in this study, selecting single nucleotide polymorphisms (SNPs) as the instrumental variables, taking inverse variance weighted as the main analysis method and further verifying its sensitivity by MR‒Egger, MR-PRESSO and weighted median. The heterogeneity test was conducted by the MR‒Egger intercept test, Cochrane’s Q test, MR-PRESSO global test, leave-one-out and funnel plot.
Results
A total of 40, 14, 12, 41, 34 and 30 SNPs were selected to represent coffee, juice, yogurt, tea, alcohol and milk intake from the MRC IEU and GSCAN. The DR data were extracted from the FinnGen consortium with 14584 cases and 202082 controls. Coffee can increase the risk of DR (IVW, odds ratio (OR) [confidence intervals (CI)] 1.39 [1.02–1.90], P = 0.037), and the result was consistent with background diabetic retinopathy (BKG_DR) (IVW, OR [CI] 2.56 [1.20–5.47], P = 0.015) and proliferative diabetic retinopathy (PDR) (IVW, OR [CI] 1.75 [1.20–2.56], P = 0.004). In addition,other beverage intake were not found to be causally related to DR.
Conclusion
Genetic level evidence suggests that coffee consumption is a risk factor for DR and should be limited in diabetic mellitus patient daily life, which provides advice on habitual diet management for patients with diabetic mellitus
How Much Energy Do E’Athletes Use During Gameplay? Quantifying Energy Expenditure and Heart Rate Variability within E’Athletes
Authors: Nicholson Mitchell , Poulus Dylan , Robergs Rob , Kelly Vincent , McNulty Craig 
Published: November 2023

Abstract

Background
Research into esports suggests that e’athletes experience multiple physiological stressors and demands during competition and training. The physiological demands of esports are poorly understood and need to be investigated further to inform future training guidelines, optimise performance outcomes, and manage e’athlete wellbeing. The aim of this research was to quantify the metabolic rate of esports gameplay and compare this outcome with heart rate variability within expert e’athletes.
Results
Thirteen healthy male participants ranked within the top 10% of their game respective esports title participated within the study (age = 20.7 ± 2.69 years; BMI = 24.6 ± 5.89 kg·m− 2). Expired gas analysis indirect calorimetry measured gas exchange during rest and gaming. Compared to resting conditions, competitive esports gameplay significantly increased median energy expenditure (1.28 (IQR 1.16–1.49) kcal·min− 1 vs. 1.45 (IQR 1.20–1.77) kcal·min− 1, p = .02), oxygen consumption (0.27 (IQR 0.24–0.30) L·min− 1 vs. 0.29 (IQR 0.24–0.35) L·min− 1, p = .02) and carbon dioxide production (0.20 (IQR 0.19–0.27) L·min− 1vs. 0.27 (IQR 0.24–0.33 ) L·min− 1, p = .01). Competitive gameplay also resulted in a significant increase in heart rate (84.5 (IQR 74.1–96.1) bpm vs. 87.1 (IQR 80.3–104) bpm, p = .01) and decrease in R-R interval’s (710 (IQR 624–810) ms vs. 689 (IQR 579–747) ms, p = .02) when compared to rest. However, there was no significant differences in time or frequency measures of heart rate variability.
Conclusions
The data reveal there are increased physiological responses to metabolic rate, energy expenditure and cardiovascular function to esports game play within expert e’athletes. Further physiological research into the physical demands on e’athletes, the influence of different training programs to esport performance, and the added multivariate determinants to elite level esport performance are warranted.
Share to Gain: Collaborative Learning with Dynamic Membership via Multi-Key Homomorphic Encryption
Authors: Kang David Ha Eun , Kim Duhyeong , Song Yongsoo , Lee Dongwon , Kwak Hyesun , Anthony Brian 
Published: November 2023

Abstract
In this manuscript, we develop a multi-party framework tailored for multiple data contributors seeking machine learning insights from combined data sources. Grounded in statistical learning principles, we introduce the Multi-Key Homomorphic Encryption Logistic Regression (MK-HELR) algorithm, designed to execute logistic regression on encrypted multi-party data. Given that models built on aggregated datasets often demonstrate superior generalization capabilities, our approach offers data contributors the collective strength of shared data. Apart from facilitating logistic regression on data pooled from diverse sources, this algorithm creates a collaborative learning environment with dynamic membership. Notably, it can seamlessly incorporate new participants during the learning process, addressing the key limitation of prior methods that demanded a predetermined number of contributors to be set before the learning process begins. This flexibility is crucial in real-world scenarios, accommodating varying data contribution timelines and unanticipated fluctuations in participant numbers, due to additions and departures. Using the AI4I public predictive maintenance dataset, we demonstrate the MK-HELR algorithm, setting the stage for further research in secure, dynamic, and collaborative multi-party learning scenarios.
MIF and AHP methods for Delineation of groundwater potential zones using remote sensing and GIS Techniques in Tirunelveli, Tenkasi District, India
Authors: Prabaharan Samuel , R Viji 
Published: November 2023

Abstract

The present study aims to identifying the delineation of potential Groundwater Zones is essential for monitoring surface and conserving underground water resources. This study was analysed the morphology of earth surface characteristics such as geomorphology, Lineament Density, lithology, Slope, soil types, land use and land cover, drainage density, Land surface temperature, NDVI, Rainfall and Topographic wetness index (TWI) parameters to delineate the potential groundwater zones. In the present paper applies the Analytical Hierarchical process (AHP) and Multi- influencing factors (MIF) Methods to identify prospective groundwater zones in the Tirunelveli and Tenkasi districts of Tamil Nadu, India. In the AHP Process method, Individual parameters geometric mean and normalized weights were determined using pair-wise matrix analytical method. RS-GIS techniques were used to generate thematic map layers from normalized weights to delineate GWPZs. The GWPZs were classified as Very Low, Low, Medium, High and Very High. The Result shows the GWPZs were identified 3.57%,0.55%,6.62%,58.09% and 31.21% in the Study area for the five classes respectively. In this study, the thematic maps were also prepared by assigning fixed score and weights from the multi-influencing factor (MIF) approach. In the MIF approach, GWPZs were classified into five classes and identified 3.16%,0.33%,2.14%,61.21% and 33.16% in the Study area respectively. GWPZ maps were evaluated for both MIF and AHP techniques using Kappa statistics method with agreement values of 0.77% and 0.72% respectively. This study GIS-RS Method is more proficient and efficient to delineate the Groundwater Potential Zones.
The impact of osteogenesis imperfecta severity on oral health-related quality of life in Spain. A cross-sectional study
Authors: Elfituri Amira Ahmed , De Nova Manuel Joaquín , Najirad Mohammadamin 
Published: November 2023

Abstract
Background
Osteogenesis imperfecta (OI) affects dental and craniofacial development, therefore it can influence oral health-related quality of life (OHRQoL). The objective of this study was to explore the influence of the severity of OI on OHRQoL in adults above eighteen years old, residing in Spain.
Method
Adults with OI were recruited from the Spanish Association of Crystal Bone (AHUCE) foundation. OHRQoL was evaluated using the Oral Health Impact Profile questionnaire, Spanish version (OHIP-14sp), oral hygiene habits, and a dental care survey. Clinical and radiological dental examinations were assessed to evaluate oral conditions.
Results
A total of 65 adults (70% female) aged between nineteen and sixty-two, diagnosed with OI and classified as type I, III, and IV (n = 20, 14, and 31 respectively) participated in the research. The total OHIP-14sp scores were significantly higher (worse) for type III (23 [SD = 10]) and type IV (21.4 [SD = 12]) than for type I (13.8 [SD = 6]) (P < 0.05). The negative impact of OHRQoL was due to the association of type III OI with all domains except handicap, while type IV OI was associated with physical disability, social disability, and handicap (P < 0.05 for both).
Conclusion
The severity of OI negatively impacts OHRQoL in adults. This association is statistically significant.