bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health promotion policies, perceptions, actions and needs in sports clubs in Ireland
Authors: Van Hoye Aurelie , Cullen Benny , Lane Aoife , Volf Kevin , Kelly Liam , Garcia Bengoechea Enrique , Vuillemin Anne , Woods Catherine 
Published: January 2024

Objective: Policy development is the biggest gap for health-promoting sports clubs. The present study aims to identify Irish sports club’s involvement in health promotion (HP) policy development. Design: Mixed methods concurrent survey design, with quantitative data providing insights into priorities, activities and documentation and qualitative data documenting stakeholders’ perceived needs. Setting: Two hundred and thirty-nine sports clubs in Ireland. Method: The survey measured perceptions of HP, the importance of promoting 10 health topics (e.g. suicide prevention, healthy eating, addictive behaviours) and corresponding actions relevant to HP in club policy documents and future needs. Quantitative data were analysed using multivariate statistics. The policy cycle was used to conduct a deductive analysis of qualitative data on sports clubs’ perceived needs. Results: A high importance score (>70%) was found for the 10 health topics. Sports clubs reported their greatest investment was in physical activity promotion, and the lowest investment was in supporting the participation of disabled people. Up to two thirds of sports clubs had no HP policy. Irish sports clubs’ perceptions of HP showed higher but similar patterns of response relative to sports clubs in other countries. Conclusion: Findings suggest that sports clubs consider HP to be an important part of their remit, but up to 66% have no policy in this regard. The policy cycle analysis helped identify the key tools needed to promote sports clubs’ HP policy development. Practical implications include fostering the inclusion of HP in sports clubs’ development plans by establishing templates and receiving support from sports federations.
Novel method of multiaxis weaving and impact analysis of the ensuing composites
Authors: Shimpi Prasad , Sridharan Sugun Bangalore , Monastyreckis Gediminas , Zeleniakiene Daiva 
Published: January 2024

The study aims to develop a novel method of weaving multiaxis preform on conventional weaving machines and analyse impact tolerance of the ensuing composites along with development of finite element analysis model. An extra set of 200 tex carbon fibres, referred as bias fibres, were integrated into carbon fibre plain woven fabric during the weaving stage on a conventional closed reed weaving machine. This was achieved by partial carbon fibre weft insertion at regular intervals from both edges of the fabric. The multiaxis preform was used as ply on top of plain woven carbon fabric plies, each of 160 g per square meter aerial density. The carbon fibre composites were manufactured by infusing bisphenol F epoxy resin as a matrix and 4 plies of carbon fabric by hand layup method. The composites were subjected to low-velocity impact loading at 0.4 m height of 5.12 kg impactor, and force-time history was recorded by the piezoelectric transducer. A comparison of impact loading results showed that the multiaxis woven composites increase impact strength by 18.3% due to the reinforcement of bias fibre. Based on the test results, a finite element analysis model was developed in Ansys v.19 to simulate the stress distribution during impact loading of the multiaxis woven composites.
Identification of therapeutic targets and prognostic biomarkers of the ephrin receptor subfamily in pancreatic adenocarcinoma
Authors: Zou Jingjing , Zhang Kun , Zhu Jinde , Tu Chaoyong , Guo Jingqiang 
Published: January 2024

Objectives We aimed to examine the significance of ephrin receptor A2 (EphA2) expression in pancreatic adenocarcinoma (PAAD) and its associated mechanism. Methods EphA2 mRNA expression patterns were compared in pancreatic cancer and normal tissues using GEPIA. Kaplan–Meier analysis was used to examine the correlation between EphA2 expression and PAAD patient prognosis. EphA2 gene methylation and associations with tumor immune cell infiltration were analyzed with UALCAN and TIMER, respectively. EphA2-interacting proteins were investigated with GeneMANIA, while STRING helped predict potentially relevant signaling pathways. EphA2 protein expression was examined with immunohistochemistry (IHC) in PAAD patient tissues. Results EphA2 was highly expressed in pancreatic cancer tissues and associated with pathological stage. PAAD patients with high EphA2 expression had shorter overall survival and disease-free survival times. EphA2 expression levels were significantly and positively associated with CD4+ T cell infiltration. EphA2 can interact with ENFNA1, ACP1, and CDC42. High EphA2 mRNA expression was enriched for regulation of cell size and cell proliferation. IHC assays suggested that pancreatic cancer tissues had higher EphA2 protein levels than normal pancreatic tissues. Conclusions EphA2 is highly expressed in PAAD and closely related to poor patient prognosis, and is therefore a potential biomarker and target for PAAD diagnosis and treatment.
Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial
Authors: Raffaelli Bianca , Do Thien Phu , Chaudhry Basit Ali , Amin Faisal Mohammad , Ashina Håkan , Snellman Josefin , Maio-Twofoot Tina , Ashina Messoud 
Published: January 2024

Background The present study aimed to investigate whether levcromakalim, a KATP channel opener, induces migraine attacks in people with migraine pre-treated with erenumab, a monoclonal CGRP receptor antibody. Methods In this double-blind, placebo-controlled, two-way cross-over study, adults with migraine without aura received a subcutaneous injection of 140 mg of erenumab on day 1. Subsequently, they were randomized to receive a 20-minute infusion of 0.05 mg/ml levcromakalim or placebo on two experimental days separated by at least one week (between days 8 and 21). The primary endpoint was the difference in the incidence of migraine attacks between levcromakalim and placebo during the 12-hour post-infusion period. Results In total, 16 participants completed the study. During the 12-hour observation period, 14 (88%) of 16 participants experienced migraine attacks after levcromakalim, compared to two (12%) after placebo ( p < 0.001). The area under the curve for median headache intensity was greater after levcromakalim than placebo ( p < 0.001). Levcromakalim elicited dilation of the superficial temporal artery during the first hour after infusion, a response absent following placebo ( p < 0.001). Conclusions The induction of migraine attacks via opening of KATP channels appears independent of CGRP receptor activation. Trial Registration: ClinicalTrials.gov, Identifier NCT05889442
Intermediate Transcultural Space (ITCS) An intergenerational and multicultural approach to violence and trauma in New Caledonia
Authors: Thibouville Grégoire 
Published: January 2024

This article reports findings from four group experiments in New Caledonia. They have as a common denominator: the ‘Intermediate Transcultural Space’ as inspired by Winnicott (1971) that all feature the themes of violence, the influence of culture and support group therapy. They all take place over a period of 10 years of practice. I continued to develop each of these group formats until I eventually arrived at an intergenerational, multicultural group for adolescents with a record of violence and criminal offences who fell within the remit of the French Child and Youth Judicial Protection Service along with the Kanak Custody Senate. The group offers an accessible landing stage that allows the young people to move forward along the long road of restoring self-esteem, and transforming their trauma and violent behaviour.
Exploring Subfactors of Adult Cognitive Disengagement Syndrome and Impact on Neuropsychological Performance
Authors: Khalid Elmma , VanLandingham Hannah B. , Basurto Karen S. , Nili Amanda N. , Gonzalez Christopher , Guilfoyle Janna L. , Ovsiew Gabriel P. , Durkin Nicole M. , Ulrich Devin M. , Resch Zachary J. , Pliskin Neil H. , Soble Jason R. , Cerny Brian M. 
Published: January 2024

Objective: This study investigated subfactors of cognitive disengagement syndrome (CDS; previously referred as sluggish cognitive tempo) among adults referred for neuropsychological evaluation of attentiondeficit/hyperactivity disorder (ADHD). Method: Retrospective analyses of data from 164 outpatient neuropsychological evaluations examined associations between CDS subfactors and self-reported psychological symptoms and cognitive performance. Results: Factor analysis produced two distinct but positively correlated constructs: “Cognitive Complaints’’ and “Lethargy.” Both correlated positively with symptom reports (rs = 0.26–0.57). Cognitive Complaints correlated negatively with working memory, processing speed, and executive functioning performance (rs = −0.21 to −0.37), whereas Lethargy correlated negatively only with processing speed and executive functioning performance (rs = −0.26 to −0.42). Both predicted depression symptoms, but only Cognitive Complaints predicted inattention symptoms. Both subfactors demonstrated modest to nonsignificant associations with cognitive performance after accounting for estimated premorbid intelligence and inattention. Conclusion: Findings indicate a bidimensional conceptualization of CDS, with differential associations between its constituent subfactors, reported symptoms, and cognitive performance.
Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience
Authors: Shaheen Muhammad , Wilkins Benjamin J. , Shenoy Archana , Byrnes Kathleen , Zhang Xiaoyi Tina , González Iván A. 
Published: January 2024

Background: Pediatric granular cell tumors (GCT) involving the gastrointestinal tract (GIT) are rare with limited case report/series reported to date. Methods: Multicenter retrospective study of pediatric GIT GCT. Results: A total of 10 cases were included in the study with a median age of 13.5 years (range: 7-18 years) and were predominantly female patients (60%). In half of the patients no significant medical history was present with the remaining 5 having Crohn disease (10%), eosinophilic esophagitis (EoE) (10%), Crohn disease and EoE (10%), growth hormone deficiency (10%), and aplasia cutis congenita (10%). The GCT median size was 1.3 cm (range: 1-1.6 cm) and were more commonly located in the esophagus (70%) followed by the stomach (20%) and rectum (10%). Most of the cases showed round/polygonal tumor cells with abundant granular cytoplasm, and none of the cases had nuclear atypia, increased mitotic activity, or tumor cell necrosis. None of our cases received specific therapy for GCT other than clinical follow-up, and none of the patients had evidence of local recurrence or metastatic disease. Conclusion: We present our multicenter experience with GIT GCT, all cases had a benign course. Interestingly, 4 of the esophageal GCT cases (including 2 patients with EoE) showed an eosinophil-rich esophagitis in the underlying mucosa.
Copper Chaperone for Superoxide Dismutase Subtypes as a Prognostic Marker in Luminal B Breast Cancer
Authors: Li Yanping , Du Wenfei , Yang Rui , Wei Xiaonan , Li Haibin , Zhang Xiaoyuan 
Published: January 2024

Background: Copper chaperone for superoxide dismutase ( CCS) is an essential component of the oxidation-reduction system. In breast cancer cells, CCS expression is highly up-regulated, which contributes to cellular proliferation and migration. Breast cancer is a multifaceted disease with different tumor prognoses and responses to clinical treatments, which may be associated with multiple molecular subtypes of CCS. Methods: The CCS expression patterns in breast cancer were investigated by TNMplot, cBioPortal, and HPA network database. The correlation of CCS expression with clinicopathological parameters was analyzed using the UALCAN database. The Cancer Genome Atlas (TCGA) data set was used to analyze the Clinical characteristics of CCS in luminal B patients. The bc-GenExMiner database was used to analyze the effects of BReast-CAncer susceptibility gene (BRCA)1/2, TP53 mutation status, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER) expression on CCS expression. The survival curves and prognostic value of CCS in luminal B breast cancer were performed through Kaplan-Meier curves, univariate and multivariate Cox regression using the PrognoScan, bc-GenExMiner, and Clinical bioinformatics analysis platform. Results: We found that CCS expression was associated with patient age, race, ER, and PR status. We also discovered that BRCA1/2 mutations had an effect on CCS expression. The luminal B subtype had the highest CCS expression, which was linked to poor survival compared with other subtypes. In addition, Kaplan-Meier curve analysis showed that luminal B patients with high CCS mRNA expression showed a poor survival and the CCS gene is an independent predictor of outcome in patients with luminal B breast cancer by univariate and multivariate Cox regression. Conclusions: Our findings emphasize the significant expression of CCS in luminal B breast cancer and its potential as an autonomous prognostic determinant for this specific molecular subtype. These findings suggest that CCS holds promise as a prospective marker for the treatment of luminal B breast cancer.
Ethical dilemmas in conducting qualitative, public health research on social media: using a study on Facebook as a case
Authors: Sørensen Jane Brandt , Thomassen Jacob Lauge , Meyrowitsch Dan W. , Kingod Natassia Rosewood , Konradsen Flemming , Ploug Thomas 
Published: January 2024

Aim: Platforms on social media are increasingly used for public health research. While social media provides an exceptional opportunity to explore communication about public health topics, this practice is not without ethical dilemmas. Our aim was to identify and unfold some of these dilemmas and to suggest possible solutions and ways forward for future research. Methods: Using our own research within a closed forum for people experiencing suicidal thoughts as a case, we explored certain dilemmas and possible answers relating to whether what is to be researched falls under a public or private social media domain; we investigated avenues for obtaining access to participants in an evolving online environment; how to secure informed consent from participants; and ways of ensuring anonymity. Results: We provide recommendations and reflections that we hope will offer inspiration for researchers embarking on similar social media public health research within and beyond suicide research. Conclusions: The ethical framework commonly referred to in health research, based on confidentiality, anonymity, informed consent and doing no harm must be adjusted to be relevant for a social media context where technologies and regulations are constantly being altered.
Pelvic AVM Embolization: A Tricky Affair—Multicenter Retrospective Experience
Authors: Szmygin Maciej , Giurazza Francesco , Marini Pierre De , Jargiełło Tomasz , Pyra Krzysztof 
Published: January 2024

Purpose: Pelvic arteriovenous malformations (pAVMs) are congenital or acquired vascular anomalies, presenting with hematuria, menometrorrhagia, pelvic pain, and varices; they can be life-threatening in case of rupture. Surgical therapies have been proposed but endovascular embolization has been recognized as the primary modality. The aim of this article was to report a retrospective multicenter experience concerning embolization of pelvic AVMs and provide literature overview. Materials and Methods: We describe 18 patients (14 female and 4 male) diagnosed with pAVM and treated with minimally invasive methods. The pre-procedural imaging evaluation was based on transpelvic and/or transvaginal color Doppler ultrasound, contrast-enhanced computed tomography, and/or magnetic resonance. In 3 cases, the malformation was congenital and in other 15, acquired. Most common symptoms were menometrorrhagia, hematuria, pelvic pain and pressure, and heaviness in the lower abdominal region. In 10 cases (56%), only 1 procedure was required. Eight patients underwent multistage treatment. Results: Complete occlusion of the lesion in post-procedural angiography was observed in 12 patients (67%). No major periprocedural complications were observed. In 14 cases (78%), both satisfactory embolization and significant clinical improvement was achieved in long-term follow-up. Sixteen patients (88%) were at least satisfied with the clinical outcome. One patient reported subsequent successful pregnancy 5 years after the treatment. Conclusion: Hemodynamics of pAVM are variable and thorough understanding of the vessel anatomy is crucial in planning and choosing proper treatment. Both transarterial and percutaneous direct puncture embolization strategies appear safe, technically feasible, and clinically effective. Clinical Impact In this manuscript, we discuss the role of interventional radiology methods in the treatment of pelvic arteriovenous malformations along with its advantages, limitations and possible complications. In addition to this, we review the current literature and confront our findings with those made by other authors. We believe that modern endovascular methods offer safe and reliable alternative for traditional surgical therapy and should be therefore considered during multidisciplinary treatment of these patients.
The “Bag of Bones” Treatment of Comminuted Intra-articular Distal Humerus Fractures in the Elderly
Authors: Garg Rohit , Vezeridis Peter S. , Monica James T. , Mudgal Chaitanya S. 
Published: January 2024

Background: Extensively comminuted intra-articular distal humerus fractures in the elderly present a challenging therapeutic dilemma. The purpose of this study was to investigate the results of nonoperative treatment of these fractures in a select subset of patients. Methods: Patients treated with nonoperative management for a comminuted intra-articular distal humerus fracture between 2007 and 2018 were reviewed. Patients were administered 3 elbow-specific functional outcomes instruments. Results: A total of 8 patients (2 men, 6 women) were treated with brief immobilization followed by early range of motion. All had fractures with extensive comminution of the articular surface such that open reduction and internal fixation was not feasible. Average age was 70 years. At an average of 33 months postinjury, average flexion was 124°, and extension was −27°, with full forearm rotation. No patients required pain medications at the latest follow-up. At 33 months of follow-up, the average Mayo Elbow Performance Score was 92/100 (100 optimal), Oxford Elbow Score was 43/48 (48 optimal), and Quick Disabilities of the Arm, Shoulder, and Hand Score was 10/100 (0 optimal). All patients were satisfied with the nonsurgical treatment that they received. Conclusions: Nonoperative treatment for comminuted intra-articular distal humerus fractures results in acceptable functional outcome in elderly patients and should be considered when the fracture is not amenable to internal fixation and in lower-demand patients with higher surgical risk.
Optimizing Ultrasonic Extraction and Purification of Nuciferine With Response Surface Method
Authors: Ren Xinshui , Wu Mengdie , Liu Simin , Pan Hongzhi 
Published: January 2024

Background Lotus leaves are obtained from plants belonging to the genus Nelumbo in the Nymphaeaceae family. They serve both as agricultural produce and traditional Chinese medicinal herbs. Nuciferine, an amorphine alkaloid found in lotus leaves, holds significance due to its anti-inflammatory, lipid-lowering, and hypoglycemic properties. Objective The factors influencing nuciferine extraction from lotus leaves using the dipping-acid-assisted ultrasonic extraction method (DAUEM) have received limited attention. This study aims to optimize DAUEM conditions (ethanol concentration, solvent-to-material ratio, and ultrasonic extraction time) through a Box-Behnken response surface design. Methods Nuciferine purification from lotus leaves is achieved using D101 macroporous adsorptive resin. A single-factor test, with ethanol concentration ( V/V), solvent-to-material ratio ( V/M), and ultrasonic extraction time as variables, serves as a basis for optimizing the nuciferine extraction process via the response surface methodology. Results The highest nuciferine yield (0.1035 ± 0.005)% was obtained using 74% ethanol ( V/V), a 26:1 solvent-to-material ratio, and an 82min extraction time. Nuciferine purity reached 67.14% using 70% ethanol as the eluent and high-performance liquid chromatography for determination. DAUEM effectively extracts nuciferine from lotus leaves, with optimization achieved using Box-Behnken response surface methodology. D101 macroporous adsorption resin efficiently separates and purifies nuciferine in lotus leaves. Conclusion This experiment demonstrates good precision and accuracy, making it suitable for the extraction, separation, and purification of nuciferine in lotus leaves. The method lays the foundation for the development and utilization of nuciferine.
Is the Number of Citations Related to the Study Methodology in Shoulder Arthroplasty Literature? A Bibliometric and Statistical Analysis of Current Evidence
Authors: de Giovanni Roberto , Guarino Amedeo , Rossi Valentina , Bruzzese Dario , Mariconda Massimo , Cozzolino Andrea 
Published: January 2024

Background We reviewed the shoulder arthroplasty (SA) literature to correlate citations, methodological characteristics and quality of most-cited articles in this field. We hypothesized that a greater number of citations would be found for high-quality clinical studies. Methods We searched the Web of Knowledge database for the 50 most-cited articles about SA and collected author name, publication year, country of origin, journal, article type, level of evidence (LoE), subject of paper, type of arthroplasty and metrics (number of citations and citation rate). Coleman Methodology Score (CMS) was computed for clinical articles. Statistical analysis of variance and correlation coefficients were used to investigate the relationship between different variables. Results Out of the selected 50 studies on SA, 26% were nonclinical. There were 15,393 citations overall (mean 307.8), with a mean 19.5 citations per year (range 48.3-6.7). Thirty or 60% of all articles were LoE IV. All studies were published between 1984 and 2011 in 8 journals. Reverse SA (RSA) was the most common subject (36% of studies). The United States was the country responsible for most contributions (50% of studies). CMS ranged from 81 to 38 (mean 59.6). RSA received the highest number of citations ( P < .001), independently from country of origin ( P = .137) and LoE ( P = .723). CMS correlated with citation rate ( r = 0.397; P = .013) and publication year (tau = 0.397; P = .013), but not with LoE ( P = .204). Conclusion In SA literature, citation rate positively correlates with methodological quality of a study, independently from publication country and LoE. Among most-cited papers, RSA is the most common standalone subject.