bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real life data comparing weekly VCD and twice weekly VCD protocols in newly diagnosed multiple myeloma patients
Authors: CENGİZ Esra , CAN Ferda , GÜNEŞ Ahmet Kürşad , CERAN Funda , DAĞDAŞ Simten , ÖZET Gülsüm , DİLEK İmdat 
Published: January 2024

Background This study aimed to evaluate the efficacy and side effects of bortezomib, cyclophosphamide, and dexamethasone (VCD) treatment, which is frequently preferred in primary care in patients with multiple myeloma in our country, with two applications per week and one application per week.
Methods A total of 141 patients who received VCD in the induction treatment of newly diagnosed multiple myeloma were retrospectively reviewed and analyzed. Both treatment groups were evaluated in terms of efficacy and side effects.
Results A total of 141 patients with newly diagnosed multiple myeloma who received VCD in induction therapy were included in the study. The median age was 62 years. Among the 141 patients included in the study, 57 received treatment two days a week, and 84 received treatment one day a week. Sixty-one (43.3%) patients were female and 80 (56.7%) were male. There was no significant difference between the two groups regarding post-treatment response rates after the 2nd cycle VCD regimen (p=0.378) and the 4th cycle VCD regimen (p=0.965). Patients receiving weekly VCD regimens had a significantly higher rate of receiving other regimens, and the additional VCD regimen of autologous stem cell transplant (ASCT) was significantly higher in patients who received a VCD regimen twice a week compared to the other group (p
PENDAMPINGAN KONSELING INDIVIDU TERHADAP PPKS DIBALAI PERLINDUNGAN DAN REHABILITASI SOSIAL WANITA (BPRSW) SIDOARUM, SLEMAN YOGYAKARTA.
Authors: Surianti Surianti , Wahyuni Susi Arum 
Published: January 2024

Penelitian ini bertujuan dalam melakukan pendampingan konseling individu di Balai Perlindungan dan Rehabilitasi Sosial Wanita Yogyakarta dan juga memberikan beberapa treatment dengan menggunakan pendekatan spiritual dalam membantu konseli. Pendampingan konseling individu pada konselli yang mengalami disfungsi sosial dalam prosesnya diharapkan dapat membantu konselli menjadi pulih dalam permasalahan mental yang dialami. Dengan diberikanya pendampingan konseling individu terhadap PPKS diharapkan mereka dapat mengatasi permasalaahan yang tengah dihadapi dan juga membantu mereka untuk menyusun target kedepan yang dapat menunjang kehidupanya ketika kembali ke lingkungan masyarakat. Metode yang digunakan dalam penelitian ini merupakan penelitian kualitatif studi kasus yang mana penelitian ini dilakukan proses pendampingan konseling individu. Metode pengumpulan data yang dilakukan menggunakan metode wawancara. Dalam proses penelitian ini dilakukan pengumpulan data dan analisis kesimpulan dari apa yang telah dideskripsikan dilapangan. Hasil dari penelitian ini menunjukkan bahwa dari beberapa kali pendampingan konseling individu dilakukan kepada konseli terlihat perubahan yang dialaami konseli meskipun belum menunjukkan hasil maksimal akan tetapi pendampingan yang dilakukan sedikit membantu menumbuhkan kembali sisi spiritual pada diri konseli dan sikap emosional yang sudah dapat di kendalikan dengan baik.
Blended Librarianship as a Fulcrum for Librarians’ Relevance in a Developing Country
Authors: Ifijeh Goodluck , Izuagbe Roland , Fawole Oluwatoyin Omoyeni , Ilogho Julie 
Published: January 2024

The paper examined the emergence and important role of blended librarianship as a fulcrum of relevance for librarians in Nigerian universities. It x-rayed the global trends in blended librarianship vis-à-vis the Nigerian situation. Furthermore, the study considered perceived challenges libraries may be confronted with in deploying relevant ICT infrastructure geared towards transitioning from traditional to hybrid services provision for the successful implementation of blended librarianship. The paper recommended the design and implementation of an appropriate framework for the development of ICTs in Nigerian universities, urgency in the acquisition of new skill sets by academic librarians in Nigeria, while also calling on relevant stakeholders to review the current curricula of Nigerian library schools to reflect current realities in the work place.
Green Initiative and Environmental Sustainability in South South Nigerian Academic Libraries
Authors: David-West Boma Torukwein , Wali Nkiruka Blessing 
Published: January 2024

Green initiative is a global phenomenon and one of the UN 2030 sustainable development goals on environmental sustainability. The green library is gradually being popularized because of the eco degradation that is ongoing globally. This study explores the level of awareness of librarians, availability and strategies employed by libraries for green initiatives. Three research questions and hypotheses guided the study. A descriptive survey research design method was used for the study. The population of the study is 102 librarians in South South federal University libraries using census sampling technique. The instrument (GIESAL) questionnaire was used to elicit information from the respondents. Data collected from the study were analyzed using weighted mean scores to determine the respondents' level of agreement on a particular item for the research questions. The hypotheses were tested using the z test at 0.05 significance level l. The findings revealed that the level of awareness of greening library among librarians is low, insufficient fund, lack of initiative and absence of sustainable policies. In conclusion the green initiative for environmental sustainability available in the libraries are sustainable sites, indoor environmental policy, innovation in design, water efficiency, solar and wind energy, which enhances sustainability of library resources.. The study recommended among others that there is a need to create more awareness for greening in libraries generally and employ strategic methods and planning sessions to ensure sustainability
Descrição e relato de vivências pedagógicas
Authors: Savian Carla , De Lima Lemes Lisandra , Batista Natália 
Published: January 2024

Contexto: O presente trabalho é um relato das atividades desenvolvidas durante a disciplina de Vivências Pedagógicas II, do curso de Geografia Licenciatura, da Universidade Federal de Santa Maria (UFSM). Durante a disciplina, foram realizadas entrevistas com diferentes setores da Escola Estadual de Educação Básica Professora Margarida Lopes, em Santa Maria. Metodologia: Durante a entrevista com o setor de Atendimento Educacional Especializado (AEE), identificou-se uma demanda atrelada ao ensino de Geografia, que consistiu na adaptação de material didático para o ensino de pessoas com deficiências. Como resposta, foi desenvolvida uma oficina de Cartografia Tátil, com o auxílio de integrantes do Laboratório de Ensino e Pesquisas em Geografia e Humanidades (LEPGHU), da UFSM, da Educadora Especial e de uma Professora de Geografia da escola. Considerações Finais: A oficina foi um sucesso, tanto no quesito de organização prévia quanto na participação efetiva das alunas e dos alunos participantes.
New well water cut prediction using machine learning
Authors: Ibrayev Aktan Ye. , Kamaridenova Gaukhar Serikovna , Baluanov Bakytzhan A. , Yelemessov Azamat S. 
Published: January 2024

Background: The drilling of new wells is one of the most effective geological and technical activities. In mature fields characterized by high production of reserves and high water availability, the selection of design points for drilling is a difficult task. Forecasting the parameters of new wells is possible by using geological and hydrodynamic models or analytical methods. In this paper, the authors propose the use of machine learning algorithms to predict the initial parameters of new wells based on an extensive set of geological and field data.
Aim: The article describes the process of developing machine learning algorithms and demonstrates the performance indicators of a complex model. As part of this work, testing of machine learning algorithms was performed to predict the start-up water cut of potential candidates.
Materials and methods: Within the framework of this work, various machine learning methods were applied on geological and technical field data.
Results: The developed complex model showed acceptable convergence results based on classification and regression metrics, which indicates its applicability for predicting the start-up water cut of project wells.
Conclusion: This method of predicting indicators is an alternative tool for predicting the start-up water cut of new wells, which makes it possible to clarify and supplement the forecast parameters calculated using a geological and hydrodynamic model or empirical dependencies of the initial water cut of new wells on geological parameters.
On approaches to solving problems when modeling polymer flooding at the Kalamkas oil field
Authors: Muratova Zarina M , Tuyakov Nauryzbek K. , Tajibayev Maksat  O. 
Published: January 2024

Background: Currently, polymer flooding is one of the most effective methods for increasing reservoir recovery, accordingly and modeling this process is of particular relevance.
Aim: The purpose of hydrodynamic modeling is to predict the distribution of parameters, technological indicators, and simulate all possible development scenarios. Based on the simulation results, decisions are made on the profitability of projects.
Materials and methods: There are a number of significant problems in the process of hydrodynamic modeling, one of which is adaptation. Difficulties with adaptation are mainly associated with the incorrect determination of filtration – capacitive properties, which is directly caused by the lack of core research data. The main physical parameters that determine the filtration-capacitive properties of reservoir rocks are porosity, permeability, relative phase permeabilities, and saturation. These properties are critical for accurate fluid flow modeling and production forecasting. However, the lack of core data limits our understanding of these properties and affects the quality of model fit.
Due to the insufficient data on the oil field in this Vostok site of horizon Ю-1 of the Kalamkas field, the approved initial geological reserves differ from the reserves according to the model by approximately 20%. For a more accurate adaptation of the hydrodynamic model, the availability of current initial geological reserves is significantly insufficient.
Results: In this article, a number of approaches were applied to solve the above-mentioned problem in the hydrodynamic modeling of polymer flooding in the Kalamkas oil field, and as a result, the results obtained were demonstrated.
Conclusion: Hydrodynamic modeling allows us to conduct numerical experiments to optimize the parameters of polymer flooding, helps to study their influence and select the optimal ratio to improve the efficiency of the flooding process.
Effect of Planting Dates on Qualitative Traits of Wheat (Triticum aestivum L.) Varieties
Authors: Al-mafraji Iqtdar Khudair , Jumaa Salah Hameed , Mohammed Abdullah Hassn 
Published: January 2024

A field experiment was carried out during the winter season 2022-2023 at the research station of the Field Crops Department, College of Agriculture, Tikrit University to study the effect of planting dates on the qualitative characteristics of each of the cultivated varieties to determine the best planting date for each variety and to find the best combination between (varieties x planting dates). The experiment was applied using the Split Plot Design method using a Randomized Complete Block Design (R.C.B.D) with three replications. Main plots included planting dates (Oct. 5, Oct. 25, Nov. 15, Dec. 5, Dec. 25) while sub-plots included wheat varieties (Ibaa99, Al-Rashid, Al-Baraka, Sham6, Tammuz2, Al-Hashimiyah, Al-Nour and Al-Adnaniyah). The results showed a significant effect of the variety treatments on all studied qualitative traits. Tammuz 2 variety was superior in the protein percentage and sedimentation volume (12.32% and 30.03 ml), respectively, Sham6 variety was superior in the wet and dry gluten percentage (36.64 and 12.30%, respectively), while Ibaa99 variety was superior in the ash and flour moisture percentage (1.91 and 9.60%, respectively). Planting date treatments had a significant effect on the qualitative characteristics of wheat varieties. Planting date treatment of Dec. 25 was superior by giving the best results for the protein percentage (12.05%), wet and dry gluten percentage (35.85 and 11.97%, respectively), ash percentage (1.76%), and sedimentation volume (28.92 ml). Also, the interaction between (varieties x planting dates) had a significant impact on the qualitative traits studied, the interaction treatment of (Tammuz2 x Dec. 25) was superior by giving the best results for the protein percentage (12.76%), the interaction of (Sham6 x Dec. 25) was superior in wet and dry gluten percentages (38.96 and 12.93%, respectively), and the interaction of (Ibaa99 x Nov. 15, Dec. 5 and Dec. 25) gave the highest values of ash percentage (1.96%), sedimentation volume (35.53ml) and flour moisture percentage (9.96%), respectively.
Persepsi Mahasiswa Melakukan Bimbingan Skripsi Secara Online
Authors: Ilwana Ilwana , Karim Darwin , Woferst Rismadefi 
Published: January 2024

Bimbingan online merupakan bimbingan yang dilakukan dengan tidak adanya pertemuan langsung antara dosen pembimbing dengan mahasiswa bimbingannya, dengan adanya bimbingan skripsi secara online, mahasiswa dapat memperoleh bimbingan skripsi dimanapun dan kapanpun. Tujuan penelitian ini adalah untuk mengetahui bagaimana persepsi mahasiswa dalam melakukan bimbingan skripsi secara online. Penelitian ini menggunakan metode penelitian kuantitatif dengan desain deskriptif. Teknik pengambilan sampel adalah purposive sampling dengan jumlah responden 64 orang. Alat ukur yang digunakan adalah kuesioner yang dibagikan melalui google form. Analisis yang digunakan adalah analisis univariat. Hasil penelitian ini menunjukkan mayoritas responden berjenis kelamin perempuan yaitu 52 responden (81,3%), program kelas respon adalah angkatan 2017 yaitu angkatan 2017-1 dengan jumlah 32 responden (50,0%), dan 2017-2 dengan jumlah responden 32 (50,0%). Secara umum, hasil persepsi mahasiswa terhadap bimbingan skripsi secara online yaitu positif (84,4%). Hasil persepsi terhadap subvariabel peran dosen yaitu positif (71,9%), dan pada ketercapaian standar dan tujuan bimbingan juga mendapatkan kategori positif (59,3%), sedangkan pada penggunaan media yaitu positif (82,8%), dan pada proses pelaksanaan juga mendapatkan kategori positif yaitu (76,6%). Hasil penelitian ini menunjukkan persepsi mayoritas mahasiswa terhadap pelaksanaan bimbingan skripsi secara online adalah positif yaitu 55 responden (84,4%). Peneliti merekomendasikan agar penelitian berikutnya menggunakan variabel yang lebih spesifik dengan kondisi yang terbaru.
Sustainability and General Dental Practice: An Overview.
Authors: Fitzgerald Rhian , Millett Declan 
Published: January 2024

##Statement of the problem Sustainability recognises that the resources that we use are finite and that we should be cognisant of the way in which we use them and use them with care. ##Purpose of the study This paper aims to provide an overview of sustainability in a broad healthcare context and specifically from a dental perspective. ##Materials and Methods This publication discusses how the concept of sustainability can impact the decisions we make regarding the dentistry that we provide. We consider many relevant factors, including practice settings, travel and patient records, single-use equipment, oral hygiene, patient and treatments. ##Results and Conclusion Possible options for improving the sustainability of dental practice are proposed, ranging from “easy wins” to more significant investments in time and finance.
Analisis Tingkat Pelayanan Prasarana Sepeda Pada Kawasan Koridor Jalan Kota Kebumen Menggunakan Metode Blos
Authors: Nurochim Achmad 
Published: January 2024

Aktivitas pembangunan yang berkembang pesat di kawasan koridor jalan pusat Kota Kebumen saat ini berdampak pada peningkatan arus hingga terjadi kemacetan di beberapa ruas jalan. Terdapat 7 (tujuh) ruas jalan yang menjadi koridor utama di pusat Kota Kebumen, yaitu Jalan Soekarno Hatta, Jalan Merdeka, Jalan Mayjend. Sutoyo, Jalan Kusuma, Jalan S. Parman, Jalan Soeprapto dan Jalan Ampera. Permintaan transportasi dengan moda sepeda di kawasan ini cukup signifikan, karena banyaknya pengguna sepeda untuk mengakses kawasan sekolah serta perkantoran. Namun pola lalu lintas kondisi eksisting yang masih bercampur dengan kendaraan bermotor membuat potensi kerawanan pada aspek keselamatan yang cukup tinggi pada pengguna sepeda.Penelitian ini bertujuan untuk memperoleh tingkat pelayanan prasarana sepeda pada kawasan koridor jalan Kota Kebumen melalui observasi lapangan dengan cara : Mendapatkan data geometri ruas, data volume dan pencacahan lalu lintas (traffic counting) serta data kecepatan kendaraan bermotor. Analisis data dilakukan dengan menggunakan metode BLOS (Bicycle Level of Service).Dari hasil analisis BLOS, maka dapat disimpulkan bahwa dari pengambilan data ke 7 ruas jalan yang terbagi menjadi 14 segmen masing-masing pengambilan data 3 hari yang berbeda yaitu hari Senin, Sabtu dan Minggu pada 3 waktu yang berbeda pagi, siang dan sore hanya 1 segmen yang nilainya A semua (lingkungan sangat baik untuk sepeda), selebihnya nilainya variatif dari A sampai F (lingkungan tidak aman untuk sepeda). Dari beberapa komponen faktor perhitungan BLOS yaitu traffic counting, persentase kendaraan berat, kecepatan kendaraan, perkerasan bahu jalan dan geometri jalan penyebab utama nilai BLOS tinggi (lingkungan tidak aman untuk sepeda) adalah persentase kendaraan berat memiliki nilai tertinggi dilanjutkan jumlah kendaraan yang tinggi, sedangkan untuk faktor lain seperti kecepatan kendaraan, perkerasan bahu jalan dan geometri jalan menyumbang nilai rata-rata atau pengaruhnya tidak terlalu signifikan.
Analisis Kinerja Pegawai dalam Penggunaan Sistem Informasi Akuntansi Manajemen dan Disiplin Kerja
Authors: Nainggolan Edisah Putra 
Published: January 2024

Penelitian bertujuan untuk meneliti kinerja karyawan berdasarkan penggunaan system Informasi Akuntansi dan bagaimana dan kinerja karyawan dipengaruhi oleh disiplin kerja, penelitian ini menggunakan pendekatan kuantitatif dengan jumlah sampel sebanyak 150 orang karyawan PT. Telkom Akses Medan. Pengumpulan informasi menggunakan quesioner dan metode pengujian ini menggunakan aplikasi SmartPls. Hasil penelitian menunjukkan kualitas sistem informasi akuntansi manajemen berpengaruh signifikan dan positif terhadap kinerja, Disiplin dalam bekerja mempunyai pengaruh yang nyata dan menguntungkan terhadap produktivitas di PT. Telkom Akses Medan.
The research aims to examine employee performance based on the use of the Accounting Information system and how employee performance is influenced by work discipline. This research uses a quantitative approach with a sample size of 150 PT employees. Telkom Access Medan. Information collection uses a questionnaire and this testing method uses the SmartPls application. The research results show that the quality of the management accounting information system has a significant and positive effect on performance. Discipline at work has a real and beneficial effect on productivity at PT. Telkom Access Medan.
Single-cell data revealed CD14-type and FCGR3A-type macrophages and relevant prognostic factors for predicting immunotherapy and prognosis in stomach adenocarcinoma
Authors: Li Mengling , Lu Ming , Li Jun , Gui Qingqing , Xia Yibin , Lu Chao , Shu Hongchun 
Published: January 2024

Background
Stomach adenocarcinoma (STAD) exhibits profound tumor heterogeneity and represents a great therapeutic challenge. Single-cell sequencing technology is a powerful tool to identify characteristic cell types.

Methods
Single-cell sequencing data (scRNA-seq) GSE167297 and bulk RNA-seq data from TCGA, GTEx, GSE26901 and GSE15459 database were included in this study. By downscaling and annotating the cellular data in scRNA-seq, critical cell types in tumor progression were identified by AUCell score. Relevant gene modules were then identified by weighted gene co-expression network analysis (WGCNA). A prognostic scoring system was constructed by identifying prognostic factors in STAD by Least absolute shrinkage and selection operator (LASSO) COX model. The prognosis and model performance in the RiskScore groups were measured by Kaplan-Meier (K-M) curves and Receiver operating characteristic (ROC) curves. Nomogram was drawn based on RiskScore and prognosis-related clinical factors. In addition, we evaluated patient’s feedback on immunotherapy in the RiskScore groups by TIMER, ESTIMATE and TIDE analysis. Finally, the expression levels of prognostic factors were verified in gastric cancer cell lines (MKN7 and MKN28) and human normal gastric mucosal epithelial cells (GES-1), and the effects of prognostic factors on the viability of gastric cancer cells were examined by the CCK8 assay and cell cycle.

Results
scRNA-seq analysis revealed that 11 cell types were identified, and macrophages exhibited relatively higher AUCell scores and specifically expressed CD14 and FCGR3A. High macrophage scores worsened the prognosis of STAD patients. We intersected the specifically expressed genes in macrophages subgroups (670) and macrophage module genes (2,360) obtained from WGCNA analysis. Among 86 common genes, seven prognostic factors (RGS2, GNAI2, ANXA5, MARCKS, CD36, NRP1 and PDE4A) were identified and composed a RiskScore model. Patients in low Risk group showed a better survival advantage. Nomogram also provided a favorable prediction for survival at 1, 3 and 5 years in STAD patients. Besides, we found positive feedback to immunotherapy in patients with low RiskScore. The expression tendency of the seven prognostic factors in MKN7 and MKN28 was consistent with that in the RNA-seq data in addition to comparison of protein expression levels in the public HPA (The Human Protein Atlas) database. Further functional exploration disclosed that MARCKS was an important prognostic factor in regulating cell viability in STAD.

Conclusion
This study preliminary uncovered a single cell atlas for STAD patients, and Macrophages relevant gene signature and nomogram displayed favorable immunotherapy and prognostic prediction ability. Collectively, our work provides a new insight into the molecular mechanisms and therapeutic approach for LUAD patients.
The minimum variance hedge and the bankruptcy risk of the firm
Authors: Hahnenstein Lutz , Röder Klaus 
Published: June 2003

AbstractIn this paper, we analyze the influence of hedging with forward contracts on the firm's probability of bankruptcy (POB). The minimization of this probability can serve as a substitute for the maximization of shareholders' wealth. It is shown that the popular minimum variance hedge is generally neither necessary nor sufficient for the minimization of the firm's POB. Moreover, our model suggests a correction of the widespread view that a reduction in the variance of the future value of the firm is inevitably accompanied by a reduction in its default risk. We derive an analytical solution for the variance‐minimizing hedge ratio of a firm exposed to both input and output price uncertainty that takes into account the issue of correlation. Based on this solution, we provide a graphical analysis to prove our claim that there is a fundamental difference between hedging policies focused on bankruptcy risk and those following conventional wisdom even if positive correlation constitutes a “natural” hedge.