bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Keadilan Distributif, Keadilan Prosedural, Keadilan Interaksional, Persepsi Nilai, Terhadap Kepuasan dan Respon Positif Pelanggan Superindo Bojonegoro
Authors: Irnawati Dwi , Anggapratama Reza 
Published: October 2023

Service is the most important thing that customers need to be satisfied. If the customer is satisfied then the customer will give a positive response to the company, otherwise if the customer is not satisfied then the customer will give a negative response to the company. The purpose of this study is to empirically examine the effect of Distributive Justice, Procedural Justice, Interactional Justice and Value Perception on satisfaction and its effect on positive response by Superindo Bojonegoro customers. In this study, primary data were used with survey and questionnaire methods. In this study, 241 Superindo customers in Bojonegoro. This study used endogenous variables namely perceived value and fairness, and exogenous variables namely satisfaction, Customer Citizenship Behavior (CCB), and repeat purchase intent. The processed PLS 7.0 curve shows that value perception has a clear positive effect on CCB and customer satisfaction, and the fairness dimension has a clear positive effect on satisfaction, in addition satisfaction has a positive effect on CCB and repeat purchase intent. These results explain that satisfaction is strongly influenced by the company's services, including corporate fairness and perceived value of customers.
PENERAPAN TEORI BELAJAR BEHAVIORISTIK DALAM PEMBELAJARAN MATEMATIKA
Authors: Bila Aisyah Salsa , Rohmah Novia Aullani , Sari Khotimah Nur Indah , Arifah Lailatul , Iffah Jauhara Dian Nurul 
Published: October 2023

Teori belajar behavioristik merupakan teori belajar yang lebih mengutamakan pada perubahan tingkah laku siswa sebagai akibat adanya stimulus dan respon. Dengan kata lain, belajar merupakan bentuk perubahan yang dialami siswa dalam hal kemampuannya yang bertujuan merubah tingkah laku dengan cara interaksi antara stimulus dan respon. Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Penelitian ini bertujuan untuk melakukan pengamatan kepada guru dimana guru sebagai subjek, untuk mendeskripsikan bagaimana subjek menerapkan teori behavioristik dalam pembelajaran matematika. Hasil observasi pada kelas X TKJ 1 di SMK PGRI 1 Jombang, ditemukan hasil belajar matematika materi Barisan dan Deret Aritmatika masih rendah hal ini dikarenakan beberapa faktor diantaranya subjek hanya menerapkan beberapa langkah dalam penerapan pembelajaran teori behavioristik. Hasil penelitian menunjukkan bahwa dalam penelitian ini subjek menerapkan 12 langkah, diantaranya langkah ke 1 pada kegiatan pembelajaran penerapan teori behavioristic yaitu subjek menentukan tujuan pembelajaran. Langkah ke 2 adalah menganalisis lingkungan kelas termasuk kemampuan awal siswa. Langkah ke 3 adalah menentukan materi pembelajaran. Langkah ke 4 adalah subjek memecah materi menjadi sub-sub kecil, meliputi pokok bahasan, sub pokok bahasan, topik dan sebagainya. Langkah ke 5 adalah guru menyajikan materi pelajaran. Langkah ke 6 adalah memberikan stimulus dapat berupa pertanyaan (tertulis, tugas, lisan dan sebagainya). Langkah ke 7 adalah mengamati dan mengkaji respon yang diberikan. Langkah ke-8 adalah memberikan penguatan (positif ataupun negatif). Langkah ke-9 adalah memberikan stimulus baru. Langkah ke-10 adalah memberikan penguatan lanjutan atau hukuman. Langkah ke-11 adalah pembentukan kebiasaan melalui pengulangan. Langkah ke-12 adalah evaluasi hasil belajar.
Reducing self-harm in adolescents: the RISA-IPD individual patient data meta-analysis and systematic review
Authors: Cottrell David , Wright-Hughes Alex , Farrin Amanda , Walwyn Rebecca , Mughal Faraz , Truscott Alex , Diggins Emma , Irving Donna , Fonagy Peter , Ougrin Dennis , Stahl Daniel , Wright Judy 
Published: October 2023

Background
Self-harm is common in adolescents and a major public health concern. Evidence for effective interventions is lacking. An individual patient data meta-analysis has the potential to provide more reliable estimates of the effects of therapeutic interventions for self-harm than conventional meta-analyses, to explore which treatments are best suited to certain groups.

Method
A systematic review and individual patient data meta-analysis of randomised controlled trials of therapeutic interventions to reduce repeat self-harm in adolescents who had a history of self-harm and presented to clinical services. Primary outcome was repetition of self-harm.
The methods employed for searches, study screening and selection, and risk of bias assessment are described, with an overview of the outputs of the searching, selection and quality assessment processes. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance is followed.

Results
We identified a total 39 eligible studies, from 10 countries, where we sought Individual Patient Data (IPD), of which the full sample of participants were eligible in 18 studies and a partial sample of participants were eligible in 21 studies. We obtained IPD from 26 studies of 3448 eligible participants. For our primary outcome, repetition of self-harm, only 6 studies were rated as low risk of bias with 10 rated as high risk (although 2 of these were for secondary outcomes only).

Conclusions
Obtaining individual patient data for meta-analyses is possible but very time-consuming, despite clear guidance from funding bodies that researchers should share their data appropriately. More attention needs to be paid to seeking appropriate consent from study participants for (pseudo) anonymised data-sharing and institutions need to collaborate on agreeing template data-sharing agreements. Researchers and funders need to consider issues of research design more carefully.
Our next step is to analyse all the data we have collected to see if it will tell us more about how we might prevent repetition of self-harm in young people.

Funding
This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 17/117/11.
A plain language summary of this research article is available on the NIHR Journals Library Website https://doi.org/10.3310/GTNT6331.
Characteristics of speech function in the process of patients getting used to removable dentures
Authors: Bedelov N. N. , Kerimkhanov K. A. , Iordanishvili A. K. 
Published: October 2023

Relevance. The study of the attitude to the disease of dental patients during the adaptation period with the use of conventional clinical research methods is relatively rarely covered in the available domestic and foreign literature. Objective. To study the changes of internal disease pattern after the adaptation period completion in rehabilitation of patients with full tooth loss by full removable acrylic dentures, including the use of such orthopedic dental prosthesis together with the adhesive agent, designed to improve their fixation. Materials and methods. 48 (15 men and 33 women) elderly patients (61–74 years old) with a total loss of teeth were examined and were divided into 2 study groups: 1 – comparison group; 2 – main group. There were also examined 17 elderly people who had no defects of dental rows and formed a control group. The defects of dental rows in the patients of the 1st and 2nd groups were eliminated by making removable dentures. At the same time, during the adaptation period the patients of the second group of the study used a new domestic adhesive cream Aceptа Рarodontal with an extract of medicinal herbs for fixation of dentures. Before treatment and during the adaptation period the types of patients’ relation to the disease were investigated; for this purpose the clinical technique «Type of relation to the disease» (TORD) was usedResults. It was found that while preserving the integrity of dental rows in elderly people the types of attitude to the disease included in the conditionally adaptive block were mainly marked. At the end of adaptation period if all patients of the main group 2 had the types of attitude towards the disease included in the first conditionally adaptive block, then the patients of the comparison group 1 in only 39.1% of people revealed similar types of attitude towards the disease, which testified to the problems in adaptation to new removable acrylic dentures made for the treatment of complete tooth loss. Conclusion. The use of ASEPTA РARODONTAL adhesive cream with herbal extracts by patients provides a positive correction of the internal picture of the disease and the patient’s personal reaction to the treatment. On the basis of the carried out research it is possible to recommend to patients the domestic adhesive cream ASEPTA РARODONTAL for denture fixation in order to optimize the adaptation period to removable acrylic dentures as well as for permanent use, which will improve not only fixation and stabilization of dentures, condition of denture bed mucosa, but also quality of speech function.
Evaluation of osseointegration by resonance frequency analysis in patients with different bone mineral density: clinical and biomechanical aspects
Authors: Aghazada A. R. , Aghazada R. R. , Akhmadov I. S. , Gergieva T. F. 
Published: October 2023

The method of resonance frequency analysis was used to compare the stability of dental implants in patients with normal bone tissue condition, osteopenia and osteoporosis. The indicators allow obtaining information on the state of the implants and determining the permissible biomechanical load using an orthopedic structure. The measurement method allows observing the dynamics of the osteointegration process, and, if necessary, make timely adjustments to the functional load.Material and methods: comprehensive examination and treatment of 690 patients who applied to the clinic for dental flaw removal by dental implantation. Among them, 547 were (79.3%) women and 143 (20.7%) men. In preparation for dental implantation operations, all patients, except for the standard examination, were also densitometrically examined by double X-ray photon absorptiometry, which revealed systemic changes in bone mineral density. Stability of dental implants and osteointegration were monitored by resonance frequency analysis.Results: the overall value of the resonance-frequency analysis, regardless of the region of implants installed in patients with normal bone tissue, differed from those of the osteopenia and osteoporosis group, and was respectively higher by 7.1% (p < 0.001) and 10.1% (p < 0.001). The overall rate in the osteopenia group was higher, and differed from such a group of patients with osteoporosis by 5.7% (p < 0.001).Conclusion: the results of the resonance-frequency analysis provide significant information about the state of the implant-bone interface at different stages of treatment and at control examinations of patients. The measurement method allows observing the dynamics of the osteointegration process, and, if necessary, make timely adjustments to the functional load. Resonance frequency analysis is an important method for documenting the clinical outcome of implantation.
The choice of local anesthesia in the treatment of permanent molars in children aged 7–12 years
Authors: Anisimova E. N. , Anisimova N. Y. , Soykher M. I. , Khodnenko O. V. , Yerilin E. A. , Kravchenko I. A. 
Published: October 2023

Relevance. Effective pain relief is required for high-quality outpatient dental treatment in children. Рeriodontal local anesthetic methods are easier to implement and safer for young patients. Purpose. To conduct a comparative analysis of the use of various local anesthetics when using a modified periodontal method in the treatment of caries and pulpitis of permanent teeth in children 7–12 years old at an outpatient dental appointment. Materials and methods. The study involved 108 children of the 7–12 years old age group, who need treatment for caries and pulpitis of permanent molars. Local anesthetic was administrated 4% solution of articaine without a vasoconstrictor, with epinephrine at concentrations of 1:200,000, 1:400,000, 2% solution of articaine without a vasoconstrictor and with epinephrine 1:200,000. To determine the effectiveness of the treatment a developed analog-visual scale was used. Results. The high efficiency and safety of the use of modified periodontal anesthesia using 2 and 4% solutions of articaine with epinephrine in the treatment of permanent molars in children aged 7–12 years was determined.
In vivo validation of a mechanically adaptive microfluidic intracortical device as a platform for sustained local drug delivery
Authors: Kim Youjoung , Druschel Lindsey N. , Mueller Natalie , Sarno Danielle , Gisser Kaela , Hess-Dunning Allison , Capadona Jeffrey R. 
Published: October 2023

Introduction: Intracortical microelectrodes (IME) are vital to properly functioning brain-computer interfacing (BCI). However, the recording electrodes have shown a steady decline in performance after implantation, mainly due to chronic inflammation. Compliant materials have been explored to decrease differential strain resulting in lower neural inflammation. We have previously developed a fabrication method for creating mechanically adaptive microfluidic probes made of a cellulose nanocrystal (CNC) polymer nanocomposite material that can become compliant after implantation. Here, we hypothesized that our device, would have a similar tissue response to the industry standard, allowing drug delivery therapeutics to improve neural inflammation in the future.Methods: RNA expression analysis was performed to determine the extent of neural inflammation and oxidative stress in response to the device compared to controls and to naïve shame tissue.Results: Results presented for both four- and eight-weeks post-implantations suggest that our device offers a promising platform technology that can be used to deliver therapeutic strategies to improve IME performance.
Potential chemoprotective effects of active ingredients in Salvia miltiorrhiza on doxorubicin-induced cardiotoxicity: a systematic review of in vitro and in vivo studies
Authors: Wang Qingqing , Li Jiaxian , Chu Xuelei , Jiang Xiaochen , Zhang Chuanlong , Liu Fudong , Zhang Xiyuan , Li Yi , Shen Qian , Pang Bo 
Published: October 2023

BackgroundRecently, attention has been paid to the protective properties of active ingredients in Salvia miltiorrhiza (AISM) against organ toxicity induced by chemotherapy drugs. Purpose of the present systematic review is to evaluate the chemoprotective effects and mechanisms of AISM on in vitro and in vivo models of doxorubicin-induced cardiotoxicity (DIC).MethodsAccording to the PRISMA guideline, the current systematic review was conducted in the Web of Science, PubMed, Embase, and the Cochrane Library to collect all relevant in vitro and in vivo studies on “the role of AISM on DIC” published up until May 2023. The SYRCLE's tool was used to identify potential risk of bias.ResultsTwenty-two eligible articles were included in this systematic review. Eleven types of active ingredients in Salvia miltiorrhiza were used for DIC, which have the following effects: improvement of physical signs and biochemical indicators, reduction of cardiac function damage caused by DIC, protection of heart tissue structure, enhancement of myocardial cell viability, prevention of cardiomyocyte apoptosis, increase of the chemosensitivity of cancer cells to Doxorubicin, etc. The cardioprotective mechanism of AISM involves inhibiting apoptosis, attenuating oxidative stress, suppressing endoplasmic reticulum (ER) stress, decreasing inflammation, improving mitochondrial structure and function, affecting cellular autophagy and calcium homeostasis. The quality scores of included studies ranged from 4 to 7 points (a total of 10 points), according to SYRCLE's risk of bias tool.ConclusionThis systematic review demonstrated that AISM have chemoprotective effects on DIC in vivo and in vitro models through several main mechanisms such as anti-apoptosis, antioxidant effects, anti-ER stress, and anti-inflammatory.
Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes
Authors: Chung Jin Ook , Park Seon-Young , Cho Dong Hyeok , Chung Dong Jin , Chung Min Young 
Published: October 2023

AimsTo explore the relationship between plasma leucine-rich α-2-glycoprotein 1 (LRG1) level and the degree of urinary albumin excretion in patients with type 2 diabetes.MethodsWe evaluated 332 patients with type 2 diabetes in a cross-sectional study.ResultThe plasma LRG1 level differed significantly according to the quartiles of urinary albumin excretion (Q1 [&lt;7.7 mg/g], 17.1 μg/mL; Q2 [7.7–15.0 mg/g], 17.5 μg/mL; Q3 [15.1–61.4 mg/g], 18.6 μg/mL; Q4 [≥61.5 mg/g], 22.3 μg/mL; p for trend = 0.003) under adjustment with other covariates. A positive correlation was found between plasma LRG1 level and urinary albumin excretion (ρ = 0.256, p &lt;0.001). According to a multivariate model, the association between LRG1 and urinary albumin excretion remained significant, under adjustment for confounding factors (β = 0.285, p &lt;0.001).ConclusionPlasma LRG1 level was independently associated with urinary albumin excretion in patients with type 2 diabetes. This study suggests that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.
Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study
Authors: Zhao Mingjian , Lv Huiyun , Zhang Yunshu , Zhao Hongliang , Qin Hongzhi 
Published: October 2023

BackgroundAging is an inescapable process, but it can be slowed down, particularly facial aging. Sex and growth hormones have been shown to play an important role in the process of facial aging. We investigated this association further, using a two-sample Mendelian randomization study.MethodsWe analyzed genome-wide association study (GWAS) data from the UK Biobank database comprising facial aging data from 432,999 samples, using two-sample Mendelian randomization. In addition, single-nucleotide polymorphism (SNP) data on sex hormone-binding globulin (SHBG) and sex steroid hormones were obtained from a GWAS in the UK Biobank [SHBG, N = 189,473; total testosterone (TT), N = 230,454; bioavailable testosterone (BT), N = 188,507; and estradiol (E2), N = 2,607)]. The inverse-variance weighted (IVW) method was the major algorithm used in this study, and random-effects models were used in cases of heterogeneity. To avoid errors caused by a single algorithm, we selected MR-Egger, weighted median, and weighted mode as supplementary algorithms. Horizontal pleiotropy was detected based on the intercept in the MR-Egger regression. The leave-one-out method was used for sensitivity analysis.ResultsSHBG plays a promoting role, whereas sex steroid hormones (TT, BT, and E2) play an inhibitory role in facial aging. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels had no significant effect on facial aging, which is inconsistent with previous findings in vitro.ConclusionRegulating the levels of SHBG, BT, TT, and E2 may be an important means to delay facial aging.
Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study
Authors: Finucane Francis M. , Gibson Irene , Hughes Robert , Murphy Enda , Hynes Lisa , Harris Aisling , McGuire Brian E. , Hynes Mary , Collins Chris , Cradock Kevin , Seery Suzanne , Jones Jennifer , O’Brien Tim , O’Donnell Martin J. 
Published: October 2023

BackgroundIndividual responses to behavioural weight loss interventions can vary significantly, and a better understanding of the factors associated with successful treatment might help to target interventions for those who will benefit the most. We sought to identify demographic and clinical characteristics that predicted intervention “success” (defined as ≥5% weight loss) and other health gains in patients with severe obesity attending a ten-week structured lifestyle modification programme.MethodsWe conducted a prospective cohort study of all 1122 patients (751 (66.9%) female, mean age 47.3 ± 11.9 years, mean body mass index (BMI) 46.7 ± 7.8 kgm-2) referred from our hospital-based obesity clinic, who started the structured lifestyle programme between 2012-2019. We compared routine clinical measures such as weight, fitness, blood pressure, lipids and HbA1c at baseline and follow-up. We also used validated questionnaires to quantify anxiety, depression and health-related quality of life.ResultsOf 1122 patients who started, 877 (78.2%) completed the programme and attended for follow up. Of these, 12.8% lost ≥5% body weight. The amount of weight lost was a strong and consistent predictor of improvements in metabolic, cardiovascular, and mental health, even after adjusting for age, sex, programme attendance and baseline fitness. Older age, male sex, being physically active and having lower anxiety and depression scores at baseline predicted greater weight loss. Younger age, depression and longer wait time to start the intervention were associated with drop-out.ConclusionsIn adults with severe obesity completing a structured lifestyle modification programme, older age and good mental health were associated with programme completion and attaining ≥5% weight loss. The magnitude of weight lost was a strong predictor of improvements in cardiovascular, metabolic and mental health associated with programme completion.
Causal association of circulating cytokines with sepsis: a Mendelian randomization study
Authors: Lin Shan , Mao Xueyan , He Wanmei 
Published: October 2023

BackgroundObservational studies have reported an association between circulating cytokines and sepsis. However, the precise causal relationship between these factors remains unclear. The objective of this study was to explore the causal link between circulating cytokines and sepsis using genetic data within the framework of Mendelian Randomization (MR).MethodsWe performed a two-sample MR analysis to investigate this causality relationship in individuals of European ancestry. The publicly available genome-wide association studies (GWAS) statistics were used. We selected eligible instrumental single nucleotide polymorphisms (SNPs) that were significantly related to the circulating cytokines. Multiple MR analysis approaches were carried out, which included inverse variance weighted (IVW), Weighted Median, MR-Egger, Weighted Mode, Simple Mode, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.ResultsWe found evidence to support the causal role of genetically predicted circulating levels on decreased risk of sepsis, including RANTES (OR = 0.920, 95% CI: 0.849-0.997, P = 0.041) and basic fibroblast growth factor (basic-FGF) (OR = 0.869, 95% CI: 0.766-0.986, P = 0.029). Additionally, MR analysis positive causal association of between beta-nerve growth factor (β-NGF) and sepsis (OR = 1.120, 95% CI: 1.037-1.211, P = 0.004). The results of MR-Egger, Weighted Median, Weighted Mode, and Simple Mode methods were consistent with the IVW estimates. Sensitivity analysis showed no horizontal pleiotropy to bias the causal estimates.ConclusionThis MR study provides first novel evidence that genetically predicted causal association of circulating levels of RANTES, basic-FGF, and β-NGF with altered sepsis risk. The findings shed light on the potential involvement of these cytokines in sepsis pathogenesis. Although requiring additional confirmation, the results contribute new insights into cytokine mediators in sepsis and suggest promising future research directions.