bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of medical abortion assisted by traditional Chinese medicine: A network meta‐analysis of randomized controlled trials
Authors: Li Fuxing , Han Mei , Zhang Jiayu , Ji Jingru , Wu Yanfei , Wei Junni 
Published: December 2023

AbstractBackgroundTo what extent traditional Chinese medicine (TCM) combined with mifepristone and misoprostol is beneficial for improving the complete abortion rate and duration of vaginal bleeding has been a subject of debate in the field of medical abortion.ObjectiveTo assess the evidence regarding the complete abortion rate and duration of vaginal bleeding of medical abortion assisted by different kinds of TCM.Search StrategyWe searched electronic databases such as PubMed, Web of Science and Cochrane Library database, China National Knowledge Internet, Wan fang Database, VIP Database, and China Biology Medicine disc from 2000 to February 15, 2023.Selection CriteriaThe control group was medical abortion with mifepristone and misoprostol, and the experimental group was medical abortion assisted by TCM.Data Collection and AnalysisMajor data extraction included sample size, age, medicine used for abortion, outcome measures. RevMan 5.3 and Stata 15.1 software were used to assess the literature quality and perform network meta‐analysis, respectively.Main ResultsA total of 73 randomized controlled trials (RCTs) with 11 683 patients and nine kinds of TCM were included in this study. Compared with mifepristone and misoprostol, eight kinds of TCM had statistical significance in improving the complete abortion rate. The effect value of Sancao decoction was 5.86 (95% confidence interval [CI] 2.53–13.58). Seven kinds of TCM shortened the duration of vaginal bleeding. The effect value of comfrey and trichosanthin decoction was −8.75 (95% CI –10.86 to −6.64).ConclusionsThis network meta‐analysis showed that Lenge Zhumo decoction and Sancao decoction could have a large beneficial effect on complete abortion rate in medical abortion during early pregnancy, and comfrey and trichosanthin decoction could be the best TCM for shortening the duration of vaginal bleeding.
Reflective supervision and reflective practice in infant mental health: A scoping review of a diverse body of literature
Authors: Tobin Mary , Carney Síle , Rogers Elaine 
Published: December 2023

AbstractReflective practice is a core component of Infant Mental Health (IMH) training and work in the form of reflective supervision/consultation (RS/C). RS/C supports and facilitates relationship‐based practice, and is considered to help prevent burnout and promote work satisfaction. In response to an identified gap in empirical research on RS/C, this scoping review aimed to give an overview of the broad range of study designs and outcomes by systematically charting empirical studies on RS/C in IMH‐based work with children and families. Searches of Academic Search Complete, CINAHL, MEDLINE, APA PsychArticles, APA PsycInfo, and Web of Science were supplemented with a Google Scholar search and citation searching. Following title/abstract screening (n = 233) and full‐text review (n = 168), 35 reports met criteria for inclusion. Key findings were organized into four categories: Essential components and processes of RS/C; Experiences and outcomes of RS/C; Emerging issues in RS/C literature; and Measuring, researching, and reporting on RS/C. Results describe the components and experience of engaging in quality RS/C, and show that practitioners generally experience RS/C as supportive and beneficial. The existing literature has some methodological limitations and further empirical research is needed on outcomes of RS/C. Practice implications and potential future research directions are discussed.
Cyclodextrin‐based nanosponges as promising carriers for active pharmaceutical ingredient
Authors: Jawaharlal Saranya , Subramanian Selvamuthukumar , Palanivel Venkatesan , Devarajan Geetha , Veerasamy Vinothkumar 
Published: December 2023

AbstractEffective drug distribution at the intended or particular location is a critical issue that researchers are now dealing. Nanosponges have significantly increased in importance in medication delivery using nanotechnology in recent years. An important step toward solving these problems has been the development of nanosponges. Recently created and proposed for use in drug delivery, nanosponge is a unique type of hyper‐crosslinked polymer‐based colloidal structures made up of solid nanoparticles with colloidal carriers. Nanosponges are solid porous particles that may hold pharmaceuticals and other actives in their nanocavities. They can be made into dosage forms for oral, parenteral, topical, or inhalation use. The targeted distribution of drugs in a regulated manner is greatly aided by nanosponge. The utilization of nanosponges, their benefits, their production processes, the polymers they are made of, and their characterization have all been covered in this review article.
Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model
Authors: Ileriturk Mustafa , Ileriturk Duygu , Kandemir Ozge , Akaras Nurhan , Simsek Hasan , Erdogan Ender , Kandemir Fatih M. 
Published: December 2023

AbstractOxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of biological and pharmacological activities, including antioxidant and anti‐inflammatory potentials. This research aimed to investigate NRG activity in OXL‐induced hepatorenal toxicity. Accordingly, OXL (4 mg/kg b.w.) in 5% glucose was injected intraperitoneally on the first, second, fifth, and sixth days, and NRG (50 and 100 mg/kg b.w.) was given orally 30 min before to treatment. Biochemical, genetic, and histological methods were utilized to investigate the function tests, oxidant/antioxidant status, inflammation, apoptosis, and endoplasmic reticulum (ER) stress pathways in kidney and liver tissues. Administration of NRG demonstrated an antioxidant effect by increasing the activities of OXL‐induced reduced antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and decreasing the elevated lipid peroxidation parameter malondialdehyde levels. Nuclear factor‐κB, tumor necrosis factor‐α, interleukin‐1β, and inducible nitric oxide synthase levels increased in OXL administered groups but reduced in NRG‐treated groups. In the OXL‐administered groups, NRG reduced the apoptosis‐inducing factors Caspase‐3 and B‐cell lymphoma 2 (Bcl‐2)‐associated X protein levels, while elevating the antiapoptotic factor Bcl‐2 levels. OXL triggered prolonged ER stress by increasing the levels of ER stress parameters activating transcription factor 6, protein kinase R‐like ER kinase, inositol‐requiring enzyme 1α, and glucose‐regulated protein 78. Therefore, with the NRG administration, this activity was reduced and the ER stress level decreased. Taken together, it was found that OXL induced toxicity by increasing the levels of urea and creatinine, alanine transaminase, aspartate aminotransferase, and alkaline phosphatase activities, inflammation, apoptosis, ER stress, and oxidants in the liver and kidney tissue, and NRG had a protective effect by reversing the deterioration in these pathways.
Russula brunneoaurantiaca, a novel taxon of Russula subg. Crassotunicata from West Bengal, India, with morpho‐molecular analysis and scanning electron microscopy
Authors: Roy Niranjan , Beypih Jeswani , Tanti Bhaben , Dutta Arun Kumar 
Published: December 2023

AbstractThis paper describes a new Russula species, R. brunneoaurantiaca, from India with morphological and molecular sequence (nrITS) data, field pictures of basidiocarps, and comparisons with close relatives. Russula brunneoaurantiaca has a brownish orange pileus with a mucilaginous surface, sub‐decurrent lamellae that are white to pale orange, a white stipe that turns yellowish brown to brown when bruised, a strong, unpleasant smell, globose to subglobose basidiospores (5.0–9.0 5.0–7.8 m) with an inamyloid suprahilar spot and ornamentation of small isolated conical warts, fusiform hymenial cystidia on gill sides (62.5–82 × 7.5–12.5 μm) and lageniform to sub‐lageniform cystidia with filiform apex near the gill edge (80–113 × 7.5–10 μm), fusiform to spindle‐shaped pileocystidia, and habitat in association with Castanopsis sp. A complete morphological description, photographs, and molecular sequence‐based phylogenetic trees demarcating the position of the novel taxon are provided.Research Highlights
Scanning electron microscopy (SEM) and subsequent DNA analysis revealed a new species of the genus Russula.
SEM analysis is an additional technique to describe the size and shape of its basidiospores as well as their ornamentation.
The diagnostic characteristics, habit, habitat, and similarities to related species are given.
Clinical and demographic comparison of celiac disease diagnosed during adulthood versus childhood and adolescence: A single‐center experience
Authors: Jain Ajay K , Chatterji Debi , Bhagat Priyanka , Jain Deepika , Sircar Shohini , Phatak Satish 
Published: December 2023

AbstractBackground and AimCeliac disease (CeD) is mainly reported from the northern and western parts of India. In central India, it is believed to be a disease of children, with limited data among adults diagnosed for the first time after the age of 18 years. Hence, we aimed to describe CeD's clinical and demographic features among adults and children/adolescents in central India.MethodsThis is a retrospective analysis of a prospectively maintained database of all patients diagnosed for CeD from 2010 to 2019. The disease in adults was confirmed when symptoms developed for the first time after 18 years and had positive anti‐transglutaminase antibodies with villous atrophy on duodenal biopsy. It was compared with pediatric patients with CeD diagnosed during the same time period.ResultsOf the 170 patients diagnosed with CeD, 118 were adults and 52 were children or adolescents. The mean age of presentation of adult CeD was 37.3 ± 11.93 years, while in the pediatric and adolescent group it was 9.19 ± 5.4 years. Classical presentation with chronic, painless, small‐bowel‐type diarrhea was seen in 44.1% of adults compared to 57.7% in the pediatric age group. Among the adult patients, 55.9% presented with nonclassical symptoms, which included abdominal pain (40.7%) and weight loss (36.4%). The common presenting symptom in children other than diarrhea was weight loss (50%) and abdominal pain (34.6%).ConclusionCeD is common in central India, with an increasing number of patients being diagnosed for the first time after 18 years of age and presenting more often with nonclassical symptoms.
Right Ventricular Function in Takayasu's Arteritis Patients With Pulmonary Artery Involvement Using MRI Feature Tracking
Authors: Li Qing , Liao Hua , Ren Yue , Yang Dan , Yun Qingping , Wang Zhiyan , Zhou Zhen , Li Shuang , Lian Jianxiu , Wang Hui , Zhang Lijun , Sun Zhonghua , Pan Lili , Xu Lei 
Published: December 2023

BackgroundPulmonary artery involvement (PAI) is not rare in Takayasu arteritis (TA). Persistently elevated pulmonary arterial pressure in TA‐PAI patients leads to pulmonary hypertension (PH), and eventually cardiac death. Thus, the early detection of right ventricular dysfunction before the onset of PH is important.PurposeTo explore the potential of right ventricular global peak longitudinal and circumferential strain (RVGLS and RVGCS, respectively) in detecting right ventricular myocardial damage in TA‐PAI patients without PH.Study TypeRetrospective.PopulationOne hundred and six TA patients (39.6 ± 13.9 years), of whom 52 were non‐PAI and 54 were PAI patients (36 without PH and 18 with PH), along with 58 sex‐ and age‐matched healthy volunteers (HVs) (36.7 ± 13.2 years). The involved arteries were validated by aorta magnetic resonance (MR) angiography and pulmonary artery computed tomography angiography.Field Strength/Sequence3 T/Cine imaging sequence with a steady‐state free precession readout.AssessmentCardiac MRI‐derived parameters measured by two radiologists independently were compared among HVs, and TA patients with and without PAI. In addition, these indices were further compared among HVs, and TA‐PAI patients with and without PH.Statistical TestsStudent's t test, one‐way ANOVA analysis, Pearson and Spearman correlation analysis, and reproducibility analysis. A P‐value of <0.05 was considered statistically significant.ResultsAlthough the TA‐PAI patients without PH had a similar RV ejection fraction (RVEF) with HV (P = 0.348), RVGLS (non‐PH 20.6 ± 3.7% vs. HV 24.0 ± 3.1%) was significantly lower and RVGCS (non‐PH 14.8 ± 3.9% vs. HV 13.0 ± 2.7%) higher. The TA‐PAI patients with PH had significantly poorer RVGLS (PH 13.5 ± 3.8% vs. non‐PH 20.6 ± 3.7%) and RVGCS (PH 10.9 ± 3.2% vs. non‐PH 14.8 ± 3.9%) than those without PH.Data ConclusionRight ventricular dysfunction was detected in the TA‐PAI patients without PH. MR‐feature tracking may be an effective method for detecting early cardiac damage in the TA‐PAI patients without PH.Level of Evidence3Technical EfficacyStage 3
Comparative Performance of 2018 LI‐RADS versus Modified LIRADS (mLI‐RADS): An Individual Participant Data Meta‐Analysis
Authors: Goins Stacy M. , Jiang Hanyu , van der Pol Christian B. , Salameh Jean‐Paul , Lam Eric , Adamo Robert G. , McInnes Matthew D.F. , Costa Andreu F. , Clarke Christopher , Choi Sang Hyun , Fraum Tyler J. , Ludwig Daniel R. , Song Bin , Joo Ijin , Kierans Andrea S. , Kim So Yeon , Kwon Heejin , Podgórska Joanna , Rosiak Grzegorz , Bashir Mustafa R. 
Published: December 2023

BackgroundLI‐RADS version 2018 (v2018) is used for non‐invasive diagnosis of hepatocellular carcinoma (HCC). A recently proposed modification (known as mLI‐RADS) demonstrated improved sensitivity while maintaining specificity and positive predictive value (PPV) of LI‐RADS category 5 (definite HCC) for HCC. However, mLI‐RADS requires multicenter validation.PurposeTo evaluate the performance of v2018 and mLI‐RADS for liver lesions in a large, heterogeneous, multi‐national cohort of patients at risk for HCC.Study TypeSystematic review and meta‐analysis using individual participant data (IPD) [Study Protocol: https://osf.io/duys4].Population2223 observations from 1817 patients (includes all LI‐RADS categories; females = 448, males = 1361, not reported = 8) at elevated risk for developing HCC (based on LI‐RADS population criteria) from 12 retrospective studies.Field Strength/Sequence1.5T and 3T; complete liver MRI with gadoxetate disodium, including axial T2w images and dynamic axial fat‐suppressed T1w images precontrast and in the arterial, portal venous, transitional, and hepatobiliary phases. Diffusion‐weighted imaging was used when available.AssessmentLiver observations were categorized using v2018 and mLI‐RADS. The diagnostic performance of each system's category 5 (LR‐5 and mLR‐5) for HCC were compared.Statistical TestsThe Quality Assessment of Diagnostic Accuracy Studies version 2 (QUADAS‐2 was applied to determine risk of bias and applicability. Diagnostic performances were assessed using the likelihood ratio test for sensitivity and specificity and the Wald test for PPV. The significance level was P < 0.05.Results17% (2/12) of the studies were considered low risk of bias (244 liver observations; 164 patients). When compared to v2018, mLR‐5 demonstrated higher sensitivity (61.3% vs. 46.5%, P < 0.001), similar PPV (85.3% vs. 86.3%, P = 0.89), and similar specificity (85.8% vs. 90.8%, P = 0.16) for HCC.Data ConclusionThis study confirms mLR‐5 has higher sensitivity than LR‐5 for HCC identification, while maintaining similar PPV and specificity, validating the mLI‐RADS proposal in a heterogeneous, international cohort.Level of Evidence3Technical EfficacyStage 2
Mpox DNA clearance in semen over 6‐month follow‐up
Authors: Candela Caterina , Galli Laura , Rizzo Alberto , Mileto Davide , Canetti Diana , Gianotti Nicola , Raccagni Angelo Roberto , Bertoni Costanza , Lucente Maria Francesca , Gismondo Maria Rita , Castagna Antonella , Nozza Silvia 
Published: December 2023

AbstractSexual intercourse is a well‐established way of transmission of mpox infection. However, it is still uncertain whether semen may represent a viral reservoir. The aim of the study was to evaluate the clearance of viral DNA in semen samples from individuals diagnosed with mpox infection over 6‐month follow‐up. This prospective, observational, single‐center study was conducted at IRCCS San Raffaele Scientific Institute, Milan, Italy, between May and October 2022 in 140 individuals who attended Sexual Health Clinic and diagnosed with mpox infection. Semen samples were collected and analyzed by real‐time polymerase chain reaction assays. The baseline collection was performed in 64 (46%) of 140 men diagnosed with mpox infection. The viral DNA was detected in 43 (67%) with median cycle threshold (Ct) 34 (interquartile range [IQR] 31–36). The research was repeated in 32 (74%) and viral DNA clearance was observed in all within 6 months in a median time of 10.5 days (IQR 7–33). Viral clearance occurred in all tested individuals, mostly within 2 weeks since the first positive test. These findings suggest a transient presence of viral DNA in semen and do not support the hypothesis of reservoir. More studies on mpox DNA detection in semen with viral culture and extended follow‐up are needed.
Genetic variability analysis of human papillomavirus 58: Novel sublineage identification and persistent infection association
Authors: Wang Yan , Gong Yingxin , Zhou Qi , Qu Wenjie , Chen Fang , Wang Yaping , Mo Jiayin , Zhang Hongwei , Lin Lin , Bi Tianyi , Wang Xujie , Gu Jiashi , Xu Congjian , Li Yanyun 
Published: December 2023

AbstractThis study aims to characterize the genetic variability of HPV58, identify novel lineages and sublineages, and explore the association between persistent/multiple HPV58 infections and genetic variation. In this study, samples from 124 women with HPV58 infection in Eastern China were collected and 81 isolates of E6 and L1 full‐length genes were successfully amplified from 55 samples. We evaluated the diversity of genetic variants and performed correlation analyses between genetic variability and pathology, vaccination, multiple infections, and persistent infections. Among the E6 and L1 gene sequences collected, the dominant prevailing sublineages were A1 (46.2%) and A2 (23.1%). In addition, we found two potential novel sublineages denoted as the A4 and A5 sublineage. A total of 50 nucleotide substitutions, including 28 synonymous substitutions and 22 nonsynonymous substitutions, were observed in the E6 and L1 genes. Among them, variants with A388C/K93N substitutions in the E6 gene correlated with persistent infection (≥1 and ≥2 years) (p < 0.005), and C307T/C66C was associated with persistent infection (≥2 years) (p < 0.005). Notably, two mutations above were detected in the isolate from the patient with breakthrough vaccine infection. Our study found two novel sublineages and sites of genetic variability in multiple and persistent infection variants. In addition, we identified two mutational sites associated with persistent infection. This study provides new insight into the clinical characteristics of HPV 58 genetic variations and offers new ideas for research on next‐generation vaccines in Eastern China.
Soil erosion control in a pasture‐dominated Mediterranean mountain environment under global change
Authors: Marien Laurène , Ciampalini Rossano , Licciardello Feliciana , Giuffrida Emanuela Rita , Pastor Amandine Valérie , Huard Frederic , Raclot Damien 
Published: December 2023

AbstractSoil erosion control is critical to global food production and ecosystem health worldwide, and particularly in the Mediterranean region, which is prone to erosion and is expected to be strongly affected by climatic and anthropogenic changes. In this paper, we explore how land use and management (LUM) can mitigate climate change impacts and increase agricultural attractiveness in pasture‐dominated Mediterranean mountain environments. One originality of the proposed research is to combine LUM scenarios incorporating environmental and socio‐economic behaviour with distributed process‐based modelling to simulate the impacts of global change. Specifically, soil erosion for different combinations of current and plausible future climate and LUM conditions were simulated on a small watershed located in eastern Sicily (Italy) using the LandSoil model. LUM scenarios were established as a modulation of environmental protection and agricultural production/diversification. The main management distinctions tested in this paper included intensive versus extensive practices for pasture, and conventional versus conservative practices for cereals and orchards. Simulations showed that the impact of climate change was very low and not significant in the studied watershed (i.e., −1.78% of erosion on average). Under current climate and compared to the baseline, LUM scenarios reported an increase in erosion for the business‐as‐usual (S1, +6.0%), market‐oriented (S2, +57.2%) and sustainability‐oriented (S4, +0.9) scenarios, respectively, whereas the nature‐oriented scenario led to a slight reduction in erosion (S3, −11.3%). Our results also emphasised that agricultural diversification coupled with adaptations in practices and management can improve the attractiveness of agriculture in pasture‐dominated environments while maintaining soil protection at an acceptable level.
Characterizing the Backscattered Spectrum of Mie Spheres
Authors: Molezuelas‐Ferreras Martín , Nodar Álvaro , Barra‐Burillo María , Olmos‐Trigo Jorge , Lasa‐Alonso Jon , Gómez‐Viloria Iker , Posada Elena , Varga J. J. Miguel , Esteban Rubén , Aizpurua Javier , Hueso Luis E. , Lopez Cefe , Molina‐Terriza Gabriel 
Published: December 2023

AbstractThis study describes both experimentally and theoretically an important hitherto undiscovered feature of the scattering of micron‐sized spherical objects when illuminated with highly focused circularly polarized light. This is a regime of high experimental relevance which has not been described in full detail. The experiments are complemented with the analytical formulas explaining the field scattered directed toward the backward hemispace. In particular, it is proven that this field shows a very regular oscillatory dependency with the optical size. This phenomenon is typically hidden in the total scattered field, as the field is scattered much less toward the backward hemisphere than toward the forward one. These regular oscillations are measured experimentally. It is proven that, by analyzing them, it is possible to determine the index of refraction of isolated micron‐sized particles, opening new paths for applications in sensing and metrology.