bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative recurrence detection using individualized circulating tumor DNA in upper tract urothelial carcinoma
Authors: Tamura Daichi , Abe Masakazu , Hiraki Hayato , Sasaki Noriyuki , Yashima‐Abo Akiko , Ikarashi Daiki , Kato Renpei , Kato Yoichiro , Maekawa Shigekatsu , Kanehira Mitsugu , Takata Ryo , Maejima Kazuhiro , Sasagawa Shota , Fujita Masashi , Suzuki Yutaka , Nakagawa Hidewaki , Iwaya Takeshi , Nishizuka Satoshi S. , Obara Wataru 
Published: December 2023

AbstractBiomarkers that could detect the postoperative recurrence of upper tract urothelial carcinoma (UTUC) have not been established. In this prospective study, we aim to evaluate the utility of individualized circulating tumor DNA (ctDNA) monitoring using digital PCR (dPCR) as a tumor recurrence biomarker for UTUC in the perioperative period. Twenty‐three patients who underwent radical nephroureterectomy (RNU) were included. In each patient, whole exome sequencing by next‐generation sequencing and TERT promoter sequencing of tumor DNA were carried out. Case‐specific gene mutations were selected from sequencing analysis to examine ctDNA by dPCR analysis. We also prospectively collected plasma and urine ctDNA from each patient. The longitudinal variant allele frequencies of ctDNA during the perioperative period were plotted. Case‐specific gene mutations were detected in 22 cases (96%) from ctDNA in the preoperative samples. Frequently detected genes were TERT (39%), FGFR3 (26%), TP53 (22%), and HRAS (13%). In all cases, we obtained plasma and urine samples for 241 time points and undertook individualized ctDNA monitoring for 2 years after RNU. Ten patients with intravesical recurrence had case‐specific ctDNA detected in urine at the time of recurrence. The mean lead time of urinary ctDNA in intravesical recurrence was 60 days (range, 0–202 days). Two patients with distal metastasis had case‐specific ctDNA in plasma at the time of metastasis. In UTUC, tumor‐specific gene mutations can be monitored postoperatively as ctDNA in plasma and urine. Individualized ctDNA might be a minimally invasive biomarker for the early detection of postoperative recurrence.
And what about today? Burden and support needs of adolescent childhood cancer survivors in long‐term follow‐up care—A qualitative content analysis
Authors: Winzig Jana , Inhestern Laura , Sigmund Désirée , Paul Verena , Hail Lesley‐Ann , Rutkowski Stefan , Escherich Gabriele , Bergelt Corinna 
Published: December 2023

AbstractPurposeChildhood cancer affects approximately 2000 children annually in Germany, and there is an increasing number of long‐term childhood cancer survivors. Due to developmental tasks, adolescent survivors in long‐term follow‐up (LTFU) care may face specific challenges and perceive different burden due to their disease. The current study explored (a) the impact of cancer and burden regarding survivorship and (b) supportive needs of adolescent childhood cancer survivors in LTFU care.MethodsSemistructured qualitative interviews were conducted with 18 adolescent childhood cancer survivors in LTFU care aged 14–18 years (average age 16.4 years). Interviews were transcribed verbatim and analysed using content analysis.ResultsBased on the exploratory research questions, two key categories were generated: (1) The impact and burden on survivors' lives during LTFU care and (2) support needs of adolescent childhood cancer survivors in LTFU care. The four subcategories that emerged regarding the impact and burden on survivors' lives during LTFU care were (1) physical consequences, (2) cognitive impairments, (3) difficulties in social interactions, and (4) psychosocial burden. Additionally, two subcategories, (1) practical and (2) emotional support needs of adolescent childhood cancer survivors were identified.ConclusionsOur results indicate that childhood cancer influences adolescent survivors' life in a negative way even many years after the end of treatment. Furthermore, parents seem to play a crucial role in the survivorship experience of childhood cancer survivors, as they remain keep responsible for most cancer‐related concerns even during LTFU care, causing adolescents to persist in the child role. A family systemic approach to care is suggested to facilitate development‐specific tasks and to enable adolescents to become autonomous adults. Still, the question remains as to who in the health care system could take over the family systemic tasks.
Association between socioeconomic status and traumatic dental injury in permanent teeth: A systematic review with meta‐analysis
Authors: Comim Letícia Donato , Marquezan Patrícia Kolling , Knorst Jessica Klöckner , Zanatta Fabrício Batistin , Zenkner Julio Eduardo do Amaral , Alves Luana Severo 
Published: December 2023

AbstractObjectiveThe aim of this study was to systematically review observational studies assessing the association between socioeconomic status (SES) and traumatic dental injuries (TDI) in permanent dentition.MethodsElectronic searches were performed in PubMed, EMBASE, Web of Science, LILACS, CINAHL, COCHANE Library and ScoINDEX databases for articles published up to February 2023. Two independent reviewers performed the search and critical appraisal of the studies. The inclusion criteria were observational studies that evaluated the association between individual‐level socioeconomic indicators and TDI (clinically examined) in permanent teeth. Quality assessment of included articles was conducted using the Newcastle‐Ottawa Scale. Global meta‐analysis was performed with all studies and different subgroup analysis based on socioeconomic indicators (household income, educational level or any other indicator), age (children, early adolescents, late adolescents or young adults) and economic classification of the country (high, upper‐middle or lower‐middle). A random‐effects model was used to estimate pooled prevalence ratios (PR) and respective 95% confidence intervals (CI) for each study.ResultsThe search strategy retrieved 11 315 publications. According to eligibility criteria, 17 articles were included in the meta‐analysis. Individuals with low SES were 17% more likely to have TDI (PR 1.17; 95% CI 1.05–1.30). The subgroup analysis also revealed that the indicator (household income, PR 1.16; 95% CI 1.00–1.34) and the economic classification of the country (upper‐middle, PR 1.19; 95% CI 1.07–1.33) influenced the association of SES with TDI occurrence.ConclusionsIndividuals with lower SES were more likely to present with TDI in permanent dentition than those with higher SES.
Blood regulator of G protein signalling 1 as a potential prognostic biomarker in surgical nonsmall cell lung cancer patients: Correlation with clinical features and survival
Authors: Wang Liping , Zhang Hui , Gu Xinliang , Wang Ying 
Published: December 2023

AbstractIntroductionRegulator of G protein signalling 1 (RGS1) closely regulates malignant phenotypes and tumour immunity in several cancers, while its clinical value in nonsmall cell lung cancer (NSCLC) is by far rarely reported. Consequently, this study aimed to explore the linkage of blood RGS1 with clinical features and prognosis in surgical NSCLC patients.MethodsTwo‐hundred and ten surgical NSCLC patients were consecutively enrolled in this study, whose RGS1 in peripheral blood mononuclear cells was determined before treatment via reverse transcriptional‐quantitative polymerase chain reaction. Additionally, the blood RGS1 was also collected from 30 healthy controls (HCs).ResultsBlood RGS1 was increased in NSCLC patients compared with HCs (P < 0.001). Elevated blood RGS1 was related to lymph node (LYN) metastasis (P = 0.001), higher tumour‐nodes‐metastasis (TNM) stage (P = 0.004), neoadjuvant chemotherapy administration (P = 0.044), shortened accumulative disease‐free survival (DFS) (P = 0.008) and overall survival (OS) (P = 0.013) in NSCLC patients. A multivariate Cox's regression analysis showed that blood RGS1 high expression could independently reflect shortened DFS (hazard ratio = 1.499, P = 0.023), whereas it could not independently predict OS (P > 0.050). Furthermore, blood RGS1 high expression was associated with shortened OS (P = 0.020) in patients with neoadjuvant therapy and with worse DFS (P = 0.028) and OS (P = 0.026) in patients with adjuvant therapy, while blood RGS1 was not linked with DFS or OS in patients without neoadjuvant or adjuvant therapy (all P > 0.050).ConclusionElevated blood RGS1 correlates with LYN metastasis, neoadjuvant chemotherapy administration, worse DFS and OS, which might serve as a useful prognostic biomarker for surgical NSCLC patients.
Recurrent and metastatic cellular cutaneous fibrous histiocytoma: A case report and literature review
Authors: Fuentes‐Sánchez Jorge , Pena‐Burgos Eva Manuela , Tapia‐Viñe Mar , Ortiz‐Cruz Eduardo José , Pozo‐Kreilinger José Juan 
Published: December 2023

AbstractCutaneous fibrous histiocytoma (FH) is considered a benign dermal tumor. The cellular variant is rare and poorly documented. Besides presenting a high risk of local recurrence, it has a low but serious metastatic potential. We present a case of metastatic cellular FH and also review the literature on this tumor, given its unusual metastatic development. A 47‐year‐old male patient presented with a lesion in the anterior surface of the right thigh, which has been present since adolescence but had grown during last year. Anatomopathological evaluation revealed a cellular FH, and the lesion was completely removed. Six months later, tumor recurrence with multiple compartment muscle involvement and pulmonary metastasis were detected. Both lesions were completely resected and after 3 years of follow‐up, the patient is asymptomatic and free of the disease. We conclude that FH should be carefully sampled to detect variants with high local recurrence rates or with some metastatic risk such as the cellular one. We recommend wide surgical resection and a close follow‐up including chest x‐rays or thorax computed tomography (CT) in all cellular FH cases with local recurrence.
Assoziation zwischen chronischer Nierenerkrankung und dem Risiko für bullöses Pemphigoid: eine nationale bevölkerungsbasierte Kohortenstudie
Authors: Yu Wen‐Ting , Ma Sheng‐Hsiang , Wu Chun‐Ying , Chen Yen‐Ling , Chang Yun‐Ting , Wu Chen‐Yi 
Published: December 2023

ZusammenfassungHintergrundStudien haben gezeigt, dass das bullöse Pemphigoid (BP) auch bei Patienten mit chronischer Nierenerkrankung (CKD, chronic kidney disease) auftritt. Unklar ist, wie hoch das BP‐Risiko bei CKD‐Patienten ist.ZielsetzungEs sollte untersucht werden, ob eine CKD das BP‐Risiko erhöht.MethodikDie Studienteilnehmer wurden für den Zeitraum von 2007 bis 2018 aus der nationalen Datenbank der taiwanesischen Krankenversicherung rekrutiert. Insgesamt wurden 637 664 neu diagnostizierte Patienten mit CKD sowie 637 664 nach Alter, Geschlecht und Komorbidität übereinstimmende Kontrollpersonen ohne CKD in die Untersuchung aufgenommen. Zur Bewertung des BP‐Risikos kam ein Modell für konkurrierende Risiken zum Einsatz.ErgebnisseNach Adjustierung für Alter, Geschlecht und Komorbidität im multivariaten Modell zeigte sich die CKD als signifikanter Risikofaktor für BP (adjustierte Hazard Ratio [aHR]: 1,29; 95%‐Konfidenzintervall [KI]: 1,17–1,42; p < 0,001). CKD‐Patienten wurden in die Gruppen dialysepflichtig und nicht‐dialysepflichtig unterteilt und mit den Patienten ohne CKD verglichen. Es zeigte sich, dass dialysepflichtige CKD‐Patienten das höchste BP‐Risiko aufwiesen (aHR 1,75; 95%‐KI 1,51–2,03), gefolgt von nicht‐dialysepflichtigen CKD‐Patienten (aHR 1,20; 95%‐KI 1,08–1,32).LimitationenDetaillierte Laborbefunde zur Einschätzung des CKD‐Schweregrads fehlten.SchlussfolgerungenIm Vergleich zu Personen ohne CKD hatten Patienten mit CKD ein 1,3‐fach erhöhtes BP‐Risiko. Bei Patienten mit dialysepflichtiger CKD war das Risiko 1,8‐fach erhöht.
Use of mouthguards in Latin American field hockey athletes during the ODESUR 2022 Games
Authors: Opazo‐Garcia Catalina , Cardozo‐Sanchez Christian , Moya‐Salazar Jeel , Gómez‐Fett María Elena , Edwards‐Toro Francisca , Gálvez‐Bravo Francisca , Elgue‐Idoyaga Nora , Contreras‐Pulache Hans 
Published: December 2023

AbstractBackground/AimsAthletes are susceptible to oral injuries. To reduce the incidence and severity of oral trauma, a custom‐made mouthguard, a device positioned in the mouth to prevent damage to teeth and surrounding structures, is recommended. In field hockey, according to the international rules of this sport, using mouthguards is not mandatory, but it is recommended to wear them at all times while practicing this discipline. We aimed to determine characteristics and differences regarding mouthguard usage among field hockey players from different countries participating in the XII ODESUR Games.MethodsWe conducted a cross‐sectional study that included 78 voluntary hockey athletes that met the inclusion criteria. The questionnaire used was validated by Panam Sports, collecting information on the type of mouthguard (custom‐made or prefabricated), and the time of use of the mouthguard (range of 5 years).ResultsOf the total number of athletes, 96% used mouthguards, of which 64% were custom‐made type, and 32% were prefabricated (p < .001). Custom‐made mouthguards were used by 100%, 89%, and 64% of athletes in Argentina, Chile, and Peru, respectively, while only 40% of athletes in Paraguay and Uruguay used them. It has also been observed that more than 50% of the individuals have not controlled and replaced their intraoral devices for more than 10 years.ConclusionsOur results reveal a problem with a public health dimension and thus invite the standardization of guidelines with an educational approach to promoting and adopting good sports practices. This report is the first on using mouthguards in high‐performance athletes during an international multisport event.
The current challenges faced by people with hemophilia B
Authors: Miesbach Wolfgang , von Drygalski Annette , Smith Clive , Sivamurthy Krupa , Pinachyan Karen , Bensen‐Kennedy Debbie , Drelich Douglass , Kulkarni Roshni 
Published: December 2023

AbstractHemophilia B (HB) is a rare, hereditary disease caused by a defect in the gene encoding factor IX (FIX) and leads to varying degrees of coagulation deficiency. The prevailing treatment for people with HB (PWHB) is FIX replacement product. The advent of recombinant coagulation products ushered in a new era of safety, efficacy, and improved availability compared with plasma‐derived products. For people with severe HB, lifelong prophylaxis with a FIX replacement product is standard of care. Development of extended half‐life FIX replacement products has allowed for advancements in the care of these PWHB. Nonetheless, lifelong need for periodic dosing and complex surveillance protocols pose substantive challenges in terms of access, adherence, and healthcare resource utilization. Further, some PWHB on prophylactic regimens continue to experience breakthrough bleeds and joint damage, and subpopulations of PWHB, including women, those with mild‐to‐moderate HB, and those with inhibitors to FIX, experience additional unique difficulties. This review summarizes the current challenges faced by PWHB, including the unique subpopulations; identifying the need for improved awareness, personalized care strategies, and new therapeutic options for severe HB, which may provide future solutions for some of the remaining unmet needs of PWHB.
For a war yet to end: Shootouts and the production of tranquillity in massive Rio de Janeiro
Authors: Cavalcanti Mariana 
Published: December 2023

AbstractThis paper explores the possibility of reading Rio's gun battles, or tiroteios, as events that produce meaning, order, and opportunities for profit and extraction, rather than as episodes of chaos and disorder. Shootouts in Rio are recurring incidents entwined with the particular historical trajectory of Rio's informal and illicit markets of different sorts – drugs, weapons, infrastructure, and security. I attempt to show how this intertwining, over time, has produced this atmosphere of war that spreads well beyond the sites where shootouts frequently occur. In the concluding section I discuss how ongoing, citizen‐based efforts at quantifying shootouts produce accumulated knowledge and maps that show us that this overarching structure allows the milícias to advance their territories over areas of the city that were free of these militarised spatial routines. I conclude by suggesting that this war ‘yet to end’ produces a constellation that fosters the continuity of Rio's shootouts.
Questionnaire for Medical Checkup of Old‐Old is non‐inferior to the Kihon Checklist in screening frailty among independent older adults aged 75 years and older: The Itabashi Longitudinal Study on Aging
Authors: Deguchi Naoki , Osuka Yosuke , Kojima Narumi , Motokawa Keiko , Iwasaki Masanori , Inagaki Hiroki , Miyamae Fumiko , Okamura Tsuyoshi , Hirano Hirohiko , Awata Shuichi , Sasai Hiroyuki 
Published: December 2023

AimThe Questionnaire for Medical Checkup of Old‐Old (QMCOO) is a 15‐item dichotomous questionnaire developed for the early detection and intervention of frailty in a nationwide health checkup program targeting the old‐old (i.e. aged ≥75 years). The Kihon Checklist (KCL) is a 25‐item questionnaire widely used for screening and self‐monitoring frailty status in administrative settings. With fewer items than the KCL, the QMCOO might expedite the frailty screening process. This study tested whether the QMCOO shows noninferiority in detecting frailty compared with the KCL.MethodsOverall, 645 participants aged ≥75 years in the Itabashi Longitudinal Study on Aging were assessed for their frailty status according to the revised Japanese version of the Cardiovascular Health Study criteria. They also completed the QMCOO and the KCL simultaneously. We compared the discriminative performance of the two questionnaires using non‐inferiority testing with an operationally defined non‐inferiority margin of 10% of the area under the receiver operating characteristic curve computed from the KCL.ResultsThe prevalence of frailty was 8.8%. The area under the receiver operating characteristic curve for the QMCOO in determining frailty was 0.76 (95% CI 0.70, 0.82), and the corresponding area under the receiver operating characteristic curve for the KCL was 0.77 (95% CI 0.69, 0.84). The QMCOO was not inferior to the KCL for frailty discrimination (P for non‐inferiority = 0.006).ConclusionsThe accuracy of the QMCOO for determining frailty was not inferior to that of the KCL. The QMCOO might be more acceptable and useful, as it can be applied in a shorter time with fewer questions than the KCL. Geriatr Gerontol Int 2024; 24: 176–181.
Teratoma‐associated and so‐called pure Wilms tumour of the ovary represent two separate tumour types with distinct molecular features
Authors: Kommoss Felix K F , Chong Anne‐Sophie , Apellaniz‐Ruiz Maria , Turashvili Gulisa , Park Kay J , Hanley Krisztina , Valera Elvis Terci , von Deimling Andreas , Vujanic Gordan , McCluggage W Glenn , Foulkes William D 
Published: December 2023

AimsOvarian Wilms tumour (WT)/nephroblastoma is an extremely rare neoplasm that has been reported to occur in pure form or as a component of a teratomatous neoplasm. We hypothesized that teratoma‐associated and pure ovarian WT may represent different tumour types with diverging molecular backgrounds. To test this hypothesis, we comprehensively characterized a series of five tumours originally diagnosed as ovarian WT.Methods and ResultsThe five cases comprised three teratoma‐associated (two mature and one immature) and two pure WTs. Two of the teratoma‐associated WTs consisted of small nodular arrangements of “glandular”/epithelial structures, while the third consisted of both an epithelial and a diffuse spindle cell/blastemal component. The pure WTs consisted of “glandular” structures, which were positive for sex cord markers (including inhibin and SF1) together with a rhabdomyosarcomatous component. The two pure WTs harboured DICER1 pathogenic variants (PVs), while the three associated with teratomas were DICER1 wildtype. Panel‐based DNA sequencing of four of the cases did not identify PVs in the other genes investigated. Analysis of the HA19/IGF2 imprinting region showed retention of imprinting in the pure WTs but loss of heterozygosity with hypomethylation of the ICR1 region in two of three teratoma‐associated WTs. Furthermore, copy number variation and clustering‐based whole‐genome DNA methylation analyses identified divergent molecular profiles for pure and teratoma‐associated WTs.ConclusionBased on the morphological features, immunophenotype, and molecular findings (DICER1 PVs, copy number, and DNA methylation profiles), we suggest that the two cases diagnosed as pure primary ovarian WT represent moderately to poorly differentiated Sertoli Leydig cell tumours (SLCTs), while the tumours arising in teratomas represent true WTs. It is possible that at least some prior cases reported as pure primary ovarian WT represent SLCTs.
In vitro diffusion of plant phenolics through the skin: A review update
Authors: Silva Gisláine C. , Rodrigues Rodney A. F. , Bottoli Carla B. G. 
Published: December 2023

AbstractObjectiveExcessive skin exposure to deleterious environmental variables results in inflammation as well as molecular and cellular impairments that compromise its functionality, aesthetic qualities, and overall well‐being. The implementation of topical administration of antioxidants and other compounds as a method for preventing or reversing damage is a rational approach. Numerous phenolic compounds derived from plants have demonstrated capabilities such as scavenging free radicals and promoting tissue healing. However, the primary obstacle lies in effectively delivering these compounds to the specific place on the skin, and accurately forecasting their diffusion through the skin can assist in determining the most effective tactics. Hence, this article provides a comprehensive analysis of recent literature pertaining to the in vitro skin diffusion characteristics of plant phenolics. The aim is to gain a deeper understanding of their behaviour when present in various forms such as solutions, suspensions, and formulations.MethodThe data on plant extracts and isolated plant phenolic compounds in vitro skin diffusion assays published over the last six years were compiled and discussed.ResultsEven though the gold standard Franz diffusion cell is the most commonly used in the assessment of in vitro plant phenolic skin diffusion profiles, a plethora of skin models and assay conditions are reported for a variety of compounds and extracts in different vehicles.ConclusionThe presence of numerous models and vehicles poses a challenge in creating correlations among the existing data on plant phenolic compounds. However, it is possible to draw some general conclusions regarding molecular, vehicle, and skin characteristics based on the gathered information.
Study on microstructures and mechanical strength of MgO–C refractories with cobalt‐loaded expanded graphite
Authors: Wang Yilong , Zhang Wenli , Zeng Xiongfeng , Huang Jiankun , Chen Yuejun , Wei Hengyong , Tu Junbo 
Published: December 2023

AbstractHerein, MgO–C refractories were prepared using fused magnesite, aluminum powder, and silicon powder as antioxidants and different kinds of graphite as carbon sources at 1200°C–1600°C. The microstructure and mechanical strength of MgO–C refractories were studied. The results showed that using cobalt‐loaded expanded graphite as partial carbon source, carbon nanotubes (CNTs) were formed in situ in MgO–C refractories at 1200°C, and the CNTs gradually reacted with Si to form SiC fibers over 1400°C. Consequently, the mechanical strength of MgO–C refractories was significantly improved.